CN1910180B - 制备2-(乙氧基甲基)-托烷衍生物的方法 - Google Patents

制备2-(乙氧基甲基)-托烷衍生物的方法 Download PDF

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Publication number
CN1910180B
CN1910180B CN2005800027516A CN200580002751A CN1910180B CN 1910180 B CN1910180 B CN 1910180B CN 2005800027516 A CN2005800027516 A CN 2005800027516A CN 200580002751 A CN200580002751 A CN 200580002751A CN 1910180 B CN1910180 B CN 1910180B
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CN
China
Prior art keywords
formula
monobromethane
phase
normal
transfer catalyst
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Expired - Fee Related
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CN2005800027516A
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English (en)
Chinese (zh)
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CN1910180A (zh
Inventor
R·厄伦茨
O·梅尔
S·瓦格纳
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NTG Nordic Transport Group AS
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Neurosearch AS
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Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN2005800027516A 2004-01-31 2005-01-20 制备2-(乙氧基甲基)-托烷衍生物的方法 Expired - Fee Related CN1910180B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102004004965A DE102004004965B4 (de) 2004-01-31 2004-01-31 Verfahren zur Herstellung eines 2-(Ethoxymethyl)-tropanderivates
DE102004004965.3 2004-01-31
PCT/EP2005/000512 WO2005073228A1 (de) 2004-01-31 2005-01-20 Verfahren zur herstellung eines 2-(ethoxymethyl)-tropanderivates

Publications (2)

Publication Number Publication Date
CN1910180A CN1910180A (zh) 2007-02-07
CN1910180B true CN1910180B (zh) 2010-05-12

Family

ID=34801391

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2005800027516A Expired - Fee Related CN1910180B (zh) 2004-01-31 2005-01-20 制备2-(乙氧基甲基)-托烷衍生物的方法

Country Status (16)

Country Link
US (1) US7544802B2 (enExample)
EP (1) EP1713800B1 (enExample)
JP (1) JP2007519660A (enExample)
CN (1) CN1910180B (enExample)
AR (1) AR047515A1 (enExample)
AT (1) ATE449095T1 (enExample)
AU (1) AU2005209382B2 (enExample)
CA (1) CA2554125A1 (enExample)
DE (2) DE102004004965B4 (enExample)
DK (1) DK1713800T3 (enExample)
MY (1) MY141935A (enExample)
NZ (1) NZ548092A (enExample)
PE (1) PE20050770A1 (enExample)
TW (1) TWI338690B (enExample)
UY (1) UY28730A1 (enExample)
WO (1) WO2005073228A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2019109050A (ru) 2016-09-07 2020-10-08 Саниона А/С Композиции тезофензина
CN115572289A (zh) * 2022-10-24 2023-01-06 龙曦宁（上海）医药科技有限公司 一种特索芬辛的合成方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997030997A1 (en) * 1996-02-22 1997-08-28 Neurosearch A/S Tropane-derivatives, their preparation and use
WO2002102801A1 (en) * 2001-05-23 2002-12-27 Neurosearch A/S Tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2003045388A1 (en) * 2001-11-30 2003-06-05 Neurosearch A/S Tropane derivatives having dopamine reuptake inhibitor activity for the treatment of ischemic diseases

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021028011A1 (en) 2019-08-09 2021-02-18 Quintus Technologies Ab System and method for handling and isostatic pressure treatment of a load

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997030997A1 (en) * 1996-02-22 1997-08-28 Neurosearch A/S Tropane-derivatives, their preparation and use
WO2002102801A1 (en) * 2001-05-23 2002-12-27 Neurosearch A/S Tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2003045388A1 (en) * 2001-11-30 2003-06-05 Neurosearch A/S Tropane derivatives having dopamine reuptake inhibitor activity for the treatment of ischemic diseases

Also Published As

Publication number Publication date
ATE449095T1 (de) 2009-12-15
AU2005209382A1 (en) 2005-08-11
TW200538455A (en) 2005-12-01
EP1713800A2 (de) 2006-10-25
WO2005073228A1 (de) 2005-08-11
US7544802B2 (en) 2009-06-09
DE102004004965B4 (de) 2006-01-05
NZ548092A (en) 2009-07-31
WO2005073228A8 (de) 2005-10-27
AU2005209382B2 (en) 2011-02-17
JP2007519660A (ja) 2007-07-19
EP1713800B1 (de) 2009-11-18
DE502005008535D1 (de) 2009-12-31
CA2554125A1 (en) 2005-08-11
UY28730A1 (es) 2005-09-30
HK1097845A1 (zh) 2007-07-06
MY141935A (en) 2010-07-30
DE102004004965A1 (de) 2005-09-01
TWI338690B (en) 2011-03-11
US20050171145A1 (en) 2005-08-04
CN1910180A (zh) 2007-02-07
DK1713800T3 (da) 2010-03-29
AR047515A1 (es) 2006-01-25
PE20050770A1 (es) 2005-11-10

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