AU2005209382B2 - Method for producing a 2-(ethoxymethyl)tropane derivative - Google Patents

Method for producing a 2-(ethoxymethyl)tropane derivative Download PDF

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Publication number
AU2005209382B2
AU2005209382B2 AU2005209382A AU2005209382A AU2005209382B2 AU 2005209382 B2 AU2005209382 B2 AU 2005209382B2 AU 2005209382 A AU2005209382 A AU 2005209382A AU 2005209382 A AU2005209382 A AU 2005209382A AU 2005209382 B2 AU2005209382 B2 AU 2005209382B2
Authority
AU
Australia
Prior art keywords
process according
formula
ethoxymethyl
transfer catalyst
base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
AU2005209382A
Other languages
English (en)
Other versions
AU2005209382A1 (en
Inventor
Richard Ehlenz
Oliver Meyer
Sascha Wagner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NTG Nordic Transport Group AS
Original Assignee
Neurosearch AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch AS filed Critical Neurosearch AS
Publication of AU2005209382A1 publication Critical patent/AU2005209382A1/en
Application granted granted Critical
Publication of AU2005209382B2 publication Critical patent/AU2005209382B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2005209382A 2004-01-31 2005-01-20 Method for producing a 2-(ethoxymethyl)tropane derivative Expired - Fee Related AU2005209382B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102004004965.3 2004-01-31
DE102004004965A DE102004004965B4 (de) 2004-01-31 2004-01-31 Verfahren zur Herstellung eines 2-(Ethoxymethyl)-tropanderivates
PCT/EP2005/000512 WO2005073228A1 (de) 2004-01-31 2005-01-20 Verfahren zur herstellung eines 2-(ethoxymethyl)-tropanderivates

Publications (2)

Publication Number Publication Date
AU2005209382A1 AU2005209382A1 (en) 2005-08-11
AU2005209382B2 true AU2005209382B2 (en) 2011-02-17

Family

ID=34801391

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005209382A Expired - Fee Related AU2005209382B2 (en) 2004-01-31 2005-01-20 Method for producing a 2-(ethoxymethyl)tropane derivative

Country Status (16)

Country Link
US (1) US7544802B2 (enExample)
EP (1) EP1713800B1 (enExample)
JP (1) JP2007519660A (enExample)
CN (1) CN1910180B (enExample)
AR (1) AR047515A1 (enExample)
AT (1) ATE449095T1 (enExample)
AU (1) AU2005209382B2 (enExample)
CA (1) CA2554125A1 (enExample)
DE (2) DE102004004965B4 (enExample)
DK (1) DK1713800T3 (enExample)
MY (1) MY141935A (enExample)
NZ (1) NZ548092A (enExample)
PE (1) PE20050770A1 (enExample)
TW (1) TWI338690B (enExample)
UY (1) UY28730A1 (enExample)
WO (1) WO2005073228A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3509597A1 (en) 2016-09-07 2019-07-17 Saniona A/S Tesofensine compositions
CN115572289A (zh) * 2022-10-24 2023-01-06 龙曦宁（上海）医药科技有限公司 一种特索芬辛的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2167876C2 (ru) * 1996-02-22 2001-05-27 Ньюросерч А/С 2,3-трансдизамещенное тропановое производное, способ его получения, фармацевтическая композиция
EP1397358A1 (en) * 2001-05-23 2004-03-17 Neurosearch A/S Tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
JP2005511639A (ja) * 2001-11-30 2005-04-28 ニューロサーチ、アクティーゼルスカブ 虚血性疾患の治療用ドパミン再取り込み阻害活性を有するトロパン誘導体
WO2021028011A1 (en) 2019-08-09 2021-02-18 Quintus Technologies Ab System and method for handling and isostatic pressure treatment of a load

Also Published As

Publication number Publication date
EP1713800B1 (de) 2009-11-18
DK1713800T3 (da) 2010-03-29
WO2005073228A8 (de) 2005-10-27
CN1910180A (zh) 2007-02-07
MY141935A (en) 2010-07-30
NZ548092A (en) 2009-07-31
CN1910180B (zh) 2010-05-12
WO2005073228A1 (de) 2005-08-11
DE102004004965A1 (de) 2005-09-01
TWI338690B (en) 2011-03-11
PE20050770A1 (es) 2005-11-10
TW200538455A (en) 2005-12-01
US20050171145A1 (en) 2005-08-04
HK1097845A1 (zh) 2007-07-06
ATE449095T1 (de) 2009-12-15
CA2554125A1 (en) 2005-08-11
DE102004004965B4 (de) 2006-01-05
JP2007519660A (ja) 2007-07-19
DE502005008535D1 (de) 2009-12-31
US7544802B2 (en) 2009-06-09
UY28730A1 (es) 2005-09-30
AR047515A1 (es) 2006-01-25
EP1713800A2 (de) 2006-10-25
AU2005209382A1 (en) 2005-08-11

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Legal Events

Date Code Title Description
MK25 Application lapsed reg. 22.2i(2) - failure to pay acceptance fee