NZ548092A - Method for producing a 2-(ethoxymethyl)tropane derivative - Google Patents
Method for producing a 2-(ethoxymethyl)tropane derivativeInfo
- Publication number
- NZ548092A NZ548092A NZ548092A NZ54809205A NZ548092A NZ 548092 A NZ548092 A NZ 548092A NZ 548092 A NZ548092 A NZ 548092A NZ 54809205 A NZ54809205 A NZ 54809205A NZ 548092 A NZ548092 A NZ 548092A
- Authority
- NZ
- New Zealand
- Prior art keywords
- formula
- tropane derivative
- ethoxymethyl
- producing
- base
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- YTEQCFHEANIYBU-FHZGLPGMSA-N (1r,5r)-4-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane Chemical class C1CC(COCC)[C@@]2([H])CC[C@]1([H])N2C YTEQCFHEANIYBU-FHZGLPGMSA-N 0.000 title 1
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 abstract 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 abstract 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- KQZPOUHEOZDZEO-CFCGPWAMSA-N [(1r,5r)-8-methyl-8-azabicyclo[3.2.1]octan-4-yl]methanol Chemical class C1CC(CO)[C@@]2([H])CC[C@]1([H])N2C KQZPOUHEOZDZEO-CFCGPWAMSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- RDHPKYGYEGBMSE-UHFFFAOYSA-N bromoethane Chemical compound CCBr RDHPKYGYEGBMSE-UHFFFAOYSA-N 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000003444 phase transfer catalyst Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004004965A DE102004004965B4 (de) | 2004-01-31 | 2004-01-31 | Verfahren zur Herstellung eines 2-(Ethoxymethyl)-tropanderivates |
| PCT/EP2005/000512 WO2005073228A1 (de) | 2004-01-31 | 2005-01-20 | Verfahren zur herstellung eines 2-(ethoxymethyl)-tropanderivates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ548092A true NZ548092A (en) | 2009-07-31 |
Family
ID=34801391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ548092A NZ548092A (en) | 2004-01-31 | 2005-01-20 | Method for producing a 2-(ethoxymethyl)tropane derivative |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7544802B2 (enExample) |
| EP (1) | EP1713800B1 (enExample) |
| JP (1) | JP2007519660A (enExample) |
| CN (1) | CN1910180B (enExample) |
| AR (1) | AR047515A1 (enExample) |
| AT (1) | ATE449095T1 (enExample) |
| AU (1) | AU2005209382B2 (enExample) |
| CA (1) | CA2554125A1 (enExample) |
| DE (2) | DE102004004965B4 (enExample) |
| DK (1) | DK1713800T3 (enExample) |
| MY (1) | MY141935A (enExample) |
| NZ (1) | NZ548092A (enExample) |
| PE (1) | PE20050770A1 (enExample) |
| TW (1) | TWI338690B (enExample) |
| UY (1) | UY28730A1 (enExample) |
| WO (1) | WO2005073228A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3509597A1 (en) | 2016-09-07 | 2019-07-17 | Saniona A/S | Tesofensine compositions |
| CN115572289A (zh) * | 2022-10-24 | 2023-01-06 | 龙曦宁（上海）医药科技有限公司 | 一种特索芬辛的合成方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2167876C2 (ru) * | 1996-02-22 | 2001-05-27 | Ньюросерч А/С | 2,3-трансдизамещенное тропановое производное, способ его получения, фармацевтическая композиция |
| EP1397358A1 (en) * | 2001-05-23 | 2004-03-17 | Neurosearch A/S | Tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| JP2005511639A (ja) * | 2001-11-30 | 2005-04-28 | ニューロサーチ、アクティーゼルスカブ | 虚血性疾患の治療用ドパミン再取り込み阻害活性を有するトロパン誘導体 |
| WO2021028011A1 (en) | 2019-08-09 | 2021-02-18 | Quintus Technologies Ab | System and method for handling and isostatic pressure treatment of a load |
-
2004
- 2004-01-31 DE DE102004004965A patent/DE102004004965B4/de not_active Expired - Fee Related
-
2005
- 2005-01-20 EP EP05701061A patent/EP1713800B1/de not_active Expired - Lifetime
- 2005-01-20 CA CA002554125A patent/CA2554125A1/en not_active Abandoned
- 2005-01-20 NZ NZ548092A patent/NZ548092A/xx unknown
- 2005-01-20 JP JP2006550028A patent/JP2007519660A/ja active Pending
- 2005-01-20 CN CN2005800027516A patent/CN1910180B/zh not_active Expired - Fee Related
- 2005-01-20 DK DK05701061.3T patent/DK1713800T3/da active
- 2005-01-20 AU AU2005209382A patent/AU2005209382B2/en not_active Expired - Fee Related
- 2005-01-20 AT AT05701061T patent/ATE449095T1/de active
- 2005-01-20 WO PCT/EP2005/000512 patent/WO2005073228A1/de not_active Ceased
- 2005-01-20 DE DE502005008535T patent/DE502005008535D1/de not_active Expired - Lifetime
- 2005-01-28 MY MYPI20050353A patent/MY141935A/en unknown
- 2005-01-28 UY UY28730A patent/UY28730A1/es not_active Application Discontinuation
- 2005-01-28 PE PE2005000107A patent/PE20050770A1/es not_active Application Discontinuation
- 2005-01-28 TW TW094102759A patent/TWI338690B/zh active
- 2005-01-28 AR ARP050100301A patent/AR047515A1/es unknown
- 2005-01-31 US US11/047,260 patent/US7544802B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1713800B1 (de) | 2009-11-18 |
| DK1713800T3 (da) | 2010-03-29 |
| WO2005073228A8 (de) | 2005-10-27 |
| CN1910180A (zh) | 2007-02-07 |
| MY141935A (en) | 2010-07-30 |
| CN1910180B (zh) | 2010-05-12 |
| WO2005073228A1 (de) | 2005-08-11 |
| DE102004004965A1 (de) | 2005-09-01 |
| TWI338690B (en) | 2011-03-11 |
| PE20050770A1 (es) | 2005-11-10 |
| TW200538455A (en) | 2005-12-01 |
| US20050171145A1 (en) | 2005-08-04 |
| HK1097845A1 (zh) | 2007-07-06 |
| AU2005209382B2 (en) | 2011-02-17 |
| ATE449095T1 (de) | 2009-12-15 |
| CA2554125A1 (en) | 2005-08-11 |
| DE102004004965B4 (de) | 2006-01-05 |
| JP2007519660A (ja) | 2007-07-19 |
| DE502005008535D1 (de) | 2009-12-31 |
| US7544802B2 (en) | 2009-06-09 |
| UY28730A1 (es) | 2005-09-30 |
| AR047515A1 (es) | 2006-01-25 |
| EP1713800A2 (de) | 2006-10-25 |
| AU2005209382A1 (en) | 2005-08-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |