CN1902156A - 茉莉酮酸酯衍生化合物、药物组合物及其使用方法 - Google Patents

茉莉酮酸酯衍生化合物、药物组合物及其使用方法 Download PDF

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Publication number
CN1902156A
CN1902156A CNA2004800358482A CN200480035848A CN1902156A CN 1902156 A CN1902156 A CN 1902156A CN A2004800358482 A CNA2004800358482 A CN A2004800358482A CN 200480035848 A CN200480035848 A CN 200480035848A CN 1902156 A CN1902156 A CN 1902156A
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CN
China
Prior art keywords
cancer
compound
leukemia
group
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2004800358482A
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English (en)
Chinese (zh)
Inventor
以列色·弗莱舍
约尔·卡什曼
朵瑞特·里斯彻
西瑞·奚模尼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ramot at Tel Aviv University Ltd
Original Assignee
Ramot at Tel Aviv University Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ramot at Tel Aviv University Ltd filed Critical Ramot at Tel Aviv University Ltd
Publication of CN1902156A publication Critical patent/CN1902156A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNA2004800358482A 2003-12-02 2004-12-01 茉莉酮酸酯衍生化合物、药物组合物及其使用方法 Pending CN1902156A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52608103P 2003-12-02 2003-12-02
US60/526,081 2003-12-02

Publications (1)

Publication Number Publication Date
CN1902156A true CN1902156A (zh) 2007-01-24

Family

ID=34652413

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2004800358482A Pending CN1902156A (zh) 2003-12-02 2004-12-01 茉莉酮酸酯衍生化合物、药物组合物及其使用方法

Country Status (7)

Country Link
US (2) US7425651B2 (enExample)
EP (1) EP1689696A2 (enExample)
JP (1) JP2007514663A (enExample)
CN (1) CN1902156A (enExample)
AU (1) AU2004295206A1 (enExample)
CA (1) CA2548173A1 (enExample)
WO (1) WO2005054172A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103429234A (zh) * 2010-12-10 2013-12-04 布罗迪健康科学有限公司 茉莉酮酸酯治疗膀胱功能障碍的用途

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004295206A1 (en) * 2003-12-02 2005-06-16 Ramot At Tel-Aviv University Ltd. Jasmonate derivative compounds, pharmaceuticals compositions and methods of use thereof
CA2632653C (en) * 2005-12-07 2014-11-04 Ramot At Tel Aviv University Ltd. Chemical derivatives of jasmonate, pharmaceutical compositions and methods of use thereof in the treatment of cancer
US9284274B2 (en) 2005-12-07 2016-03-15 Ramot At Tel-Aviv University Ltd. Chemical derivatives of jasmonate, pharmaceutical compositions and methods of use thereof
AU2006322845A1 (en) * 2005-12-07 2007-06-14 Sepal Pharma Ltd. Jasmonate derivatives, pharmaceutical compositions and methods of use thereof
US20100003346A1 (en) * 2006-07-10 2010-01-07 Eliezer Flescher Combination methods of treating cancer
US8349553B2 (en) 2007-03-15 2013-01-08 Ramot At Tel Aviv University Ltd. Jasmonate based assays for identifying compounds that selectively inhibit mitochondrial bound hexokinases
US9284252B2 (en) 2009-06-09 2016-03-15 Sepal Pharma Ltd. Use of jasmonate ester derivatives for treating benign hyperproliferative skin disorders
CN103140223A (zh) * 2010-05-19 2013-06-05 布罗迪健康科学有限公司 茉莉酮酸酯用于治疗心力衰竭及相关心脏病症的用途
BR112014006153A2 (pt) 2011-09-16 2020-12-01 Nanocare Technologies, Inc. composição farmacêutica, e, método para tratar um distúrbio
WO2016109779A1 (en) 2014-12-31 2016-07-07 Nanocare Technologies, Inc. Jasmonate derivatives and compositions thereof
CA3017432A1 (en) 2016-03-28 2017-10-05 Vidac Pharma Ltd. Stable pharmaceutical compositions for topical administration and uses thereof
WO2018083704A1 (en) 2016-11-07 2018-05-11 Vidac Pharma Ltd. Use of hexokinase 2/mitochondria-detaching compounds for activating immune responses
US11266639B2 (en) 2016-11-07 2022-03-08 Vidac Pharma Ltd. Use of hexokinase 2/mitochondria-detaching compounds for treating hexokinase-2 (HK2)-expressing cancers

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0441414A (ja) * 1990-06-04 1992-02-12 Fujisawa Pharmaceut Co Ltd 育毛料
US5118711A (en) * 1990-09-27 1992-06-02 International Flavors & Fragrances Inc. Ketone, ketoesters and alcohol in repelling insects; use of aliphatic ester in attracting insects and process and apparatus for determination of insect repellency and attractancy
US5436226A (en) * 1993-11-03 1995-07-25 The United States Of America, As Represented By The Secretary Of Agriculture Natural suppression of sprouting in stored potatoes using jasmonates
WO1997031536A1 (en) * 1996-02-28 1997-09-04 Nippon Zeon Co., Ltd. Growth regulator for crop plants and method for regulating the growth of crop plants
JP3568325B2 (ja) 1996-07-12 2004-09-22 株式会社ノエビア 抗アンドロゲン剤及び養毛剤並びに毛髪用化粧料
US6469061B1 (en) * 2001-04-04 2002-10-22 Ramot University Authority For Applied Research And Industrial Development Limited Jasmonate pharmaceutical composition for treatment of cancer
AU2004295206A1 (en) * 2003-12-02 2005-06-16 Ramot At Tel-Aviv University Ltd. Jasmonate derivative compounds, pharmaceuticals compositions and methods of use thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103429234A (zh) * 2010-12-10 2013-12-04 布罗迪健康科学有限公司 茉莉酮酸酯治疗膀胱功能障碍的用途
CN103429234B (zh) * 2010-12-10 2016-10-05 布罗迪健康科学有限公司 茉莉酮酸酯治疗膀胱功能障碍的用途

Also Published As

Publication number Publication date
US20070142474A1 (en) 2007-06-21
AU2004295206A1 (en) 2005-06-16
JP2007514663A (ja) 2007-06-07
WO2005054172A3 (en) 2005-07-07
EP1689696A2 (en) 2006-08-16
US20080319066A1 (en) 2008-12-25
WO2005054172A2 (en) 2005-06-16
US7425651B2 (en) 2008-09-16
US7683211B2 (en) 2010-03-23
CA2548173A1 (en) 2005-06-16

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