CA2548173A1 - Jasmonate derivative compounds, pharmaceuticals compositions and methods of use thereof - Google Patents
Jasmonate derivative compounds, pharmaceuticals compositions and methods of use thereof Download PDFInfo
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- CA2548173A1 CA2548173A1 CA002548173A CA2548173A CA2548173A1 CA 2548173 A1 CA2548173 A1 CA 2548173A1 CA 002548173 A CA002548173 A CA 002548173A CA 2548173 A CA2548173 A CA 2548173A CA 2548173 A1 CA2548173 A1 CA 2548173A1
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- Prior art keywords
- cancer
- carcinoma
- compound
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- 239000004480 active ingredient Substances 0.000 claims description 19
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- 125000001153 fluoro group Chemical group F* 0.000 claims description 16
- 125000006539 C12 alkyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 15
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- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 3
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- GEWDNTWNSAZUDX-WQMVXFAESA-N (-)-methyl jasmonate Chemical compound CC\C=C/C[C@@H]1[C@@H](CC(=O)OC)CCC1=O GEWDNTWNSAZUDX-WQMVXFAESA-N 0.000 description 41
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- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- WBHQBSYUUJJSRZ-UHFFFAOYSA-M sodium bisulfate Chemical compound [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 description 1
- 229910000342 sodium bisulfate Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- WSWCOQWTEOXDQX-MQQKCMAXSA-N sorbic acid group Chemical group C(\C=C\C=C\C)(=O)O WSWCOQWTEOXDQX-MQQKCMAXSA-N 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
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- 125000005531 substituted alkyleneoxy group Chemical group 0.000 description 1
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- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
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- 125000000297 undecanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52608103P | 2003-12-02 | 2003-12-02 | |
| US60/526,081 | 2003-12-02 | ||
| PCT/IL2004/001098 WO2005054172A2 (en) | 2003-12-02 | 2004-12-01 | Jasmonate derivative compounds, pharmaceuticals compositions and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2548173A1 true CA2548173A1 (en) | 2005-06-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002548173A Abandoned CA2548173A1 (en) | 2003-12-02 | 2004-12-01 | Jasmonate derivative compounds, pharmaceuticals compositions and methods of use thereof |
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| Country | Link |
|---|---|
| US (2) | US7425651B2 (enExample) |
| EP (1) | EP1689696A2 (enExample) |
| JP (1) | JP2007514663A (enExample) |
| CN (1) | CN1902156A (enExample) |
| AU (1) | AU2004295206A1 (enExample) |
| CA (1) | CA2548173A1 (enExample) |
| WO (1) | WO2005054172A2 (enExample) |
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| WO2005054172A2 (en) * | 2003-12-02 | 2005-06-16 | Ramot At Tel-Aviv University Ltd. | Jasmonate derivative compounds, pharmaceuticals compositions and methods of use thereof |
| EP1968959A2 (en) * | 2005-12-07 | 2008-09-17 | Sepal Pharma Ltd. | Jasmonate derivatives, pharmaceutical compositions and methods of use thereof |
| CA2632653C (en) | 2005-12-07 | 2014-11-04 | Ramot At Tel Aviv University Ltd. | Chemical derivatives of jasmonate, pharmaceutical compositions and methods of use thereof in the treatment of cancer |
| US9284274B2 (en) | 2005-12-07 | 2016-03-15 | Ramot At Tel-Aviv University Ltd. | Chemical derivatives of jasmonate, pharmaceutical compositions and methods of use thereof |
| CN101511351A (zh) * | 2006-07-10 | 2009-08-19 | 雷蒙特亚特特拉维夫大学有限公司 | 治疗癌症的组合方法 |
| JP2010521149A (ja) | 2007-03-15 | 2010-06-24 | ラモット アット テル−アヴィヴ ユニヴァーシティ リミテッド | ミトコンドリア結合ヘキソキナーゼを選択的に阻害する化合物の同定のためのジャスモン酸エステルに基づくアッセイ |
| US9284252B2 (en) | 2009-06-09 | 2016-03-15 | Sepal Pharma Ltd. | Use of jasmonate ester derivatives for treating benign hyperproliferative skin disorders |
| WO2011146560A2 (en) * | 2010-05-19 | 2011-11-24 | Broady Health Sciences, Llc | Use of jasmonates for treating heart failure and related cardiac disorders |
| TWI489981B (zh) * | 2010-12-10 | 2015-07-01 | 柏萊迪健康科學有限責任公司 | 使用茉莉酸治療膀胱功能障礙 |
| US8883220B2 (en) | 2011-09-16 | 2014-11-11 | Nanocare Technologies, Inc. | Compositions of jasmonate compounds |
| BR112017014229A2 (pt) | 2014-12-31 | 2018-03-06 | Nanocare Technologies, Inc. | conjugado, composição, e, método para tratamento de um distúrbio. |
| US20200297620A1 (en) | 2016-03-28 | 2020-09-24 | Vidac Pharma Ltd | Stable pharmaceutical compositions for topical administration and uses thereof |
| WO2018083704A1 (en) | 2016-11-07 | 2018-05-11 | Vidac Pharma Ltd. | Use of hexokinase 2/mitochondria-detaching compounds for activating immune responses |
| WO2018083705A1 (en) | 2016-11-07 | 2018-05-11 | Vidac Pharma Ltd. | Use of hexokinase 2/mitochondria-detaching compounds for treating hexokinase-2 (hk2)-expressing cancers |
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| JPH0441414A (ja) | 1990-06-04 | 1992-02-12 | Fujisawa Pharmaceut Co Ltd | 育毛料 |
| US5118711A (en) * | 1990-09-27 | 1992-06-02 | International Flavors & Fragrances Inc. | Ketone, ketoesters and alcohol in repelling insects; use of aliphatic ester in attracting insects and process and apparatus for determination of insect repellency and attractancy |
| US5436226A (en) * | 1993-11-03 | 1995-07-25 | The United States Of America, As Represented By The Secretary Of Agriculture | Natural suppression of sprouting in stored potatoes using jasmonates |
| ES2176686T3 (es) * | 1996-02-28 | 2002-12-01 | Nippon Zeon Co | Regulador del crecimiento para plantas de cultivo y procedimiento para la regulacion del crecimiento de plantas de cultivo. |
| JP3568325B2 (ja) | 1996-07-12 | 2004-09-22 | 株式会社ノエビア | 抗アンドロゲン剤及び養毛剤並びに毛髪用化粧料 |
| US6469061B1 (en) * | 2001-04-04 | 2002-10-22 | Ramot University Authority For Applied Research And Industrial Development Limited | Jasmonate pharmaceutical composition for treatment of cancer |
| WO2005054172A2 (en) * | 2003-12-02 | 2005-06-16 | Ramot At Tel-Aviv University Ltd. | Jasmonate derivative compounds, pharmaceuticals compositions and methods of use thereof |
-
2004
- 2004-12-01 WO PCT/IL2004/001098 patent/WO2005054172A2/en not_active Ceased
- 2004-12-01 CN CNA2004800358482A patent/CN1902156A/zh active Pending
- 2004-12-01 AU AU2004295206A patent/AU2004295206A1/en not_active Abandoned
- 2004-12-01 JP JP2006542113A patent/JP2007514663A/ja active Pending
- 2004-12-01 CA CA002548173A patent/CA2548173A1/en not_active Abandoned
- 2004-12-01 EP EP04801585A patent/EP1689696A2/en not_active Withdrawn
- 2004-12-01 US US10/581,546 patent/US7425651B2/en not_active Expired - Lifetime
-
2008
- 2008-08-26 US US12/198,559 patent/US7683211B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007514663A (ja) | 2007-06-07 |
| US7425651B2 (en) | 2008-09-16 |
| CN1902156A (zh) | 2007-01-24 |
| US7683211B2 (en) | 2010-03-23 |
| AU2004295206A1 (en) | 2005-06-16 |
| US20080319066A1 (en) | 2008-12-25 |
| US20070142474A1 (en) | 2007-06-21 |
| WO2005054172A3 (en) | 2005-07-07 |
| WO2005054172A2 (en) | 2005-06-16 |
| EP1689696A2 (en) | 2006-08-16 |
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