CN1889829B - 包含聚合稳定剂的抗微生物组合物 - Google Patents
包含聚合稳定剂的抗微生物组合物 Download PDFInfo
- Publication number
- CN1889829B CN1889829B CN2004800360853A CN200480036085A CN1889829B CN 1889829 B CN1889829 B CN 1889829B CN 2004800360853 A CN2004800360853 A CN 2004800360853A CN 200480036085 A CN200480036085 A CN 200480036085A CN 1889829 B CN1889829 B CN 1889829B
- Authority
- CN
- China
- Prior art keywords
- composition
- acid
- vinyl
- monomer
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 60
- 230000000845 anti-microbial effect Effects 0.000 title claims abstract description 17
- 239000003381 stabilizer Substances 0.000 title description 2
- 229920000642 polymer Polymers 0.000 claims abstract description 23
- -1 thiocyanate anions Chemical class 0.000 claims abstract description 23
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 claims abstract description 15
- ZMZDMBWJUHKJPS-UHFFFAOYSA-N hydrogen thiocyanate Natural products SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000000178 monomer Substances 0.000 claims description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 150000003839 salts Chemical class 0.000 claims description 10
- 229920001577 copolymer Polymers 0.000 claims description 8
- 238000012545 processing Methods 0.000 claims description 8
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 7
- 125000000129 anionic group Chemical group 0.000 claims description 6
- XMBWDFGMSWQBCA-UHFFFAOYSA-M iodide Chemical compound [I-] XMBWDFGMSWQBCA-UHFFFAOYSA-M 0.000 claims description 5
- 229920000570 polyether Polymers 0.000 claims description 5
- 230000001954 sterilising effect Effects 0.000 claims description 5
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 5
- OSSNTDFYBPYIEC-UHFFFAOYSA-N 1-ethenylimidazole Chemical compound C=CN1C=CN=C1 OSSNTDFYBPYIEC-UHFFFAOYSA-N 0.000 claims description 4
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 4
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 4
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 4
- 238000004659 sterilization and disinfection Methods 0.000 claims description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 3
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 3
- 230000003115 biocidal effect Effects 0.000 claims description 3
- ZTWTYVWXUKTLCP-UHFFFAOYSA-L ethenyl-dioxido-oxo-$l^{5}-phosphane Chemical compound [O-]P([O-])(=O)C=C ZTWTYVWXUKTLCP-UHFFFAOYSA-L 0.000 claims description 3
- 150000003951 lactams Chemical class 0.000 claims description 3
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 3
- 239000011976 maleic acid Substances 0.000 claims description 3
- 230000003641 microbiacidal effect Effects 0.000 claims description 3
- 229940124561 microbicide Drugs 0.000 claims description 3
- 239000002855 microbicide agent Substances 0.000 claims description 3
- 229920002554 vinyl polymer Polymers 0.000 claims description 3
- 241000251468 Actinopterygii Species 0.000 claims description 2
- 208000001840 Dandruff Diseases 0.000 claims description 2
- 241001465754 Metazoa Species 0.000 claims description 2
- QOSMNYMQXIVWKY-UHFFFAOYSA-N Propyl levulinate Chemical compound CCCOC(=O)CCC(C)=O QOSMNYMQXIVWKY-UHFFFAOYSA-N 0.000 claims description 2
- 238000004378 air conditioning Methods 0.000 claims description 2
- 230000003255 anti-acne Effects 0.000 claims description 2
- 230000002421 anti-septic effect Effects 0.000 claims description 2
- 238000009455 aseptic packaging Methods 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 238000004140 cleaning Methods 0.000 claims description 2
- 238000004132 cross linking Methods 0.000 claims description 2
- 239000002781 deodorant agent Substances 0.000 claims description 2
- UYMKPFRHYYNDTL-UHFFFAOYSA-N ethenamine Chemical compound NC=C UYMKPFRHYYNDTL-UHFFFAOYSA-N 0.000 claims description 2
- KKJLGRFVBCOZKZ-UHFFFAOYSA-N ethenyl dihydrogen phosphite Chemical compound OP(O)OC=C KKJLGRFVBCOZKZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000012530 fluid Substances 0.000 claims description 2
- 235000013305 food Nutrition 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims description 2
- 239000001530 fumaric acid Substances 0.000 claims description 2
- 239000010781 infectious medical waste Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000005022 packaging material Substances 0.000 claims description 2
- 239000010865 sewage Substances 0.000 claims description 2
- 239000000344 soap Substances 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 230000009182 swimming Effects 0.000 claims description 2
- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 claims description 2
- 201000004647 tinea pedis Diseases 0.000 claims description 2
- NLVXSWCKKBEXTG-UHFFFAOYSA-N vinylsulfonic acid Chemical compound OS(=O)(=O)C=C NLVXSWCKKBEXTG-UHFFFAOYSA-N 0.000 claims description 2
- 238000004065 wastewater treatment Methods 0.000 claims description 2
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 abstract description 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract description 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract description 3
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- 238000006116 polymerization reaction Methods 0.000 description 10
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 7
- 241000700605 Viruses Species 0.000 description 6
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 description 6
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 239000006210 lotion Substances 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 4
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000012141 concentrate Substances 0.000 description 4
- 239000000645 desinfectant Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 229940088598 enzyme Drugs 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 4
- TWLXDPFBEPBAQB-UHFFFAOYSA-N orthoperiodic acid Chemical compound OI(O)(O)(O)(O)=O TWLXDPFBEPBAQB-UHFFFAOYSA-N 0.000 description 4
- 102000013415 peroxidase activity proteins Human genes 0.000 description 4
- 108040007629 peroxidase activity proteins Proteins 0.000 description 4
- ZWLUXSQADUDCSB-UHFFFAOYSA-N phthalaldehyde Chemical compound O=CC1=CC=CC=C1C=O ZWLUXSQADUDCSB-UHFFFAOYSA-N 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 3
- 241000233866 Fungi Species 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 3
- 150000001450 anions Chemical class 0.000 description 3
- 239000003431 cross linking reagent Substances 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 229910052698 phosphorus Inorganic materials 0.000 description 3
- 125000002743 phosphorus functional group Chemical group 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 230000002335 preservative effect Effects 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011877 solvent mixture Substances 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- WSWCOQWTEOXDQX-UHFFFAOYSA-N 2,4-Hexadienoic acid Chemical compound CC=CC=CC(O)=O WSWCOQWTEOXDQX-UHFFFAOYSA-N 0.000 description 2
- IYOLBFFHPZOQGW-UHFFFAOYSA-N 2,4-dichloro-3,5-dimethylphenol Chemical compound CC1=CC(O)=C(Cl)C(C)=C1Cl IYOLBFFHPZOQGW-UHFFFAOYSA-N 0.000 description 2
- JECYNCQXXKQDJN-UHFFFAOYSA-N 2-(2-methylhexan-2-yloxymethyl)oxirane Chemical compound CCCCC(C)(C)OCC1CO1 JECYNCQXXKQDJN-UHFFFAOYSA-N 0.000 description 2
- UXFQFBNBSPQBJW-UHFFFAOYSA-N 2-amino-2-methylpropane-1,3-diol Chemical compound OCC(N)(C)CO UXFQFBNBSPQBJW-UHFFFAOYSA-N 0.000 description 2
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 2
- LOJHHQNEBFCTQK-UHFFFAOYSA-N 2-phenoxypropan-1-ol Chemical compound OCC(C)OC1=CC=CC=C1 LOJHHQNEBFCTQK-UHFFFAOYSA-N 0.000 description 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 2
- 241000228245 Aspergillus niger Species 0.000 description 2
- LVDKZNITIUWNER-UHFFFAOYSA-N Bronopol Chemical compound OCC(Br)(CO)[N+]([O-])=O LVDKZNITIUWNER-UHFFFAOYSA-N 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 2
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 description 2
- 108010023244 Lactoperoxidase Proteins 0.000 description 2
- 102000045576 Lactoperoxidases Human genes 0.000 description 2
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 2
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 2
- 102000004316 Oxidoreductases Human genes 0.000 description 2
- 108090000854 Oxidoreductases Proteins 0.000 description 2
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid group Chemical group C(CCCCC(=O)O)(=O)O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 229960003168 bronopol Drugs 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 2
- VDQQXEISLMTGAB-UHFFFAOYSA-N chloramine T Chemical compound [Na+].CC1=CC=C(S(=O)(=O)[N-]Cl)C=C1 VDQQXEISLMTGAB-UHFFFAOYSA-N 0.000 description 2
- 238000005660 chlorination reaction Methods 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000007334 copolymerization reaction Methods 0.000 description 2
- 229950010569 dichloroxylenol Drugs 0.000 description 2
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 235000019253 formic acid Nutrition 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 229940057428 lactoperoxidase Drugs 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 2
- 229940054441 o-phthalaldehyde Drugs 0.000 description 2
- 239000011574 phosphorus Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 239000001294 propane Substances 0.000 description 2
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 2
- 238000010526 radical polymerization reaction Methods 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- RBACIKXCRWGCBB-UHFFFAOYSA-N 1,2-Epoxybutane Chemical compound CCC1CO1 RBACIKXCRWGCBB-UHFFFAOYSA-N 0.000 description 1
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 description 1
- PBGPBHYPCGDFEZ-UHFFFAOYSA-N 1-ethenylpiperidin-2-one Chemical compound C=CN1CCCCC1=O PBGPBHYPCGDFEZ-UHFFFAOYSA-N 0.000 description 1
- JKNCOURZONDCGV-UHFFFAOYSA-N 2-(dimethylamino)ethyl 2-methylprop-2-enoate Chemical compound CN(C)CCOC(=O)C(C)=C JKNCOURZONDCGV-UHFFFAOYSA-N 0.000 description 1
- ABBGMXMPOCXVNL-UHFFFAOYSA-N 2-bromo-2-cyanoacetamide Chemical class NC(=O)C(Br)C#N ABBGMXMPOCXVNL-UHFFFAOYSA-N 0.000 description 1
- 125000000143 2-carboxyethyl group Chemical group [H]OC(=O)C([H])([H])C([H])([H])* 0.000 description 1
- CFKMVGJGLGKFKI-UHFFFAOYSA-N 4-chloro-m-cresol Chemical compound CC1=CC(O)=CC=C1Cl CFKMVGJGLGKFKI-UHFFFAOYSA-N 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- JCIUHONTIPSECE-UHFFFAOYSA-N CCCCCCCCCCCCCC.N1C=CC=CC=C1 Chemical class CCCCCCCCCCCCCC.N1C=CC=CC=C1 JCIUHONTIPSECE-UHFFFAOYSA-N 0.000 description 1
- ZKQDCIXGCQPQNV-UHFFFAOYSA-N Calcium hypochlorite Chemical compound [Ca+2].Cl[O-].Cl[O-] ZKQDCIXGCQPQNV-UHFFFAOYSA-N 0.000 description 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N Caprylic acid Natural products CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- RUPBZQFQVRMKDG-UHFFFAOYSA-M Didecyldimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC RUPBZQFQVRMKDG-UHFFFAOYSA-M 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 206010034719 Personality change Diseases 0.000 description 1
- 229920002413 Polyhexanide Polymers 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- 229920001131 Pulp (paper) Polymers 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- ZMZDMBWJUHKJPS-UHFFFAOYSA-M Thiocyanate anion Chemical compound [S-]C#N ZMZDMBWJUHKJPS-UHFFFAOYSA-M 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 241000130764 Tinea Species 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 150000008065 acid anhydrides Chemical class 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910001413 alkali metal ion Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 229910001420 alkaline earth metal ion Inorganic materials 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 125000005210 alkyl ammonium group Chemical group 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 150000001409 amidines Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000002882 anti-plaque Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000003793 antidiarrheal agent Substances 0.000 description 1
- 125000003710 aryl alkyl group Chemical group 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 238000010538 cationic polymerization reaction Methods 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- FOCAUTSVDIKZOP-UHFFFAOYSA-N chloroacetic acid Chemical compound OC(=O)CCl FOCAUTSVDIKZOP-UHFFFAOYSA-N 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 150000004292 cyclic ethers Chemical class 0.000 description 1
- 239000013530 defoamer Substances 0.000 description 1
- 239000000551 dentifrice Substances 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 1
- 150000004683 dihydrates Chemical class 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 125000005448 ethoxyethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])C([H])([H])* 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- SFNALCNOMXIBKG-UHFFFAOYSA-N ethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCO SFNALCNOMXIBKG-UHFFFAOYSA-N 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- FATAVLOOLIRUNA-UHFFFAOYSA-N formylmethyl Chemical group [CH2]C=O FATAVLOOLIRUNA-UHFFFAOYSA-N 0.000 description 1
- 229950006191 gluconic acid Drugs 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 229920000578 graft copolymer Polymers 0.000 description 1
- AHAREKHAZNPPMI-UHFFFAOYSA-N hexa-1,3-diene Chemical compound CCC=CC=C AHAREKHAZNPPMI-UHFFFAOYSA-N 0.000 description 1
- NAQMVNRVTILPCV-UHFFFAOYSA-N hexamethylene diamine Natural products NCCCCCCN NAQMVNRVTILPCV-UHFFFAOYSA-N 0.000 description 1
- 229940051250 hexylene glycol Drugs 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229940006461 iodide ion Drugs 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 238000003973 irrigation Methods 0.000 description 1
- 230000002262 irrigation Effects 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- PNLUGRYDUHRLOF-UHFFFAOYSA-N n-ethenyl-n-methylacetamide Chemical compound C=CN(C)C(C)=O PNLUGRYDUHRLOF-UHFFFAOYSA-N 0.000 description 1
- OFESGEKAXKKFQT-UHFFFAOYSA-N n-ethenyl-n-methylformamide Chemical compound C=CN(C)C=O OFESGEKAXKKFQT-UHFFFAOYSA-N 0.000 description 1
- RQAKESSLMFZVMC-UHFFFAOYSA-N n-ethenylacetamide Chemical compound CC(=O)NC=C RQAKESSLMFZVMC-UHFFFAOYSA-N 0.000 description 1
- ZQXSMRAEXCEDJD-UHFFFAOYSA-N n-ethenylformamide Chemical compound C=CNC=O ZQXSMRAEXCEDJD-UHFFFAOYSA-N 0.000 description 1
- IUWVWLRMZQHYHL-UHFFFAOYSA-N n-ethenylpropanamide Chemical compound CCC(=O)NC=C IUWVWLRMZQHYHL-UHFFFAOYSA-N 0.000 description 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N n-hexanoic acid Natural products CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
- 125000000962 organic group Chemical group 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- FHHJDRFHHWUPDG-UHFFFAOYSA-L peroxysulfate(2-) Chemical compound [O-]OS([O-])(=O)=O FHHJDRFHHWUPDG-UHFFFAOYSA-L 0.000 description 1
- 125000005499 phosphonyl group Chemical group 0.000 description 1
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical group OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 description 1
- 238000006068 polycondensation reaction Methods 0.000 description 1
- GGHDAUPFEBTORZ-UHFFFAOYSA-N propane-1,1-diamine Chemical compound CCC(N)N GGHDAUPFEBTORZ-UHFFFAOYSA-N 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 238000009938 salting Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- SDLBJIZEEMKQKY-UHFFFAOYSA-M silver chlorate Chemical compound [Ag+].[O-]Cl(=O)=O SDLBJIZEEMKQKY-UHFFFAOYSA-M 0.000 description 1
- MSFGZHUJTJBYFA-UHFFFAOYSA-M sodium dichloroisocyanurate Chemical compound [Na+].ClN1C(=O)[N-]C(=O)N(Cl)C1=O MSFGZHUJTJBYFA-UHFFFAOYSA-M 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 1
- VGTPCRGMBIAPIM-UHFFFAOYSA-M sodium thiocyanate Chemical compound [Na+].[S-]C#N VGTPCRGMBIAPIM-UHFFFAOYSA-M 0.000 description 1
- RPACBEVZENYWOL-XFULWGLBSA-M sodium;(2r)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate Chemical compound [Na+].C=1C=C(Cl)C=CC=1OCCCCCC[C@]1(C(=O)[O-])CO1 RPACBEVZENYWOL-XFULWGLBSA-M 0.000 description 1
- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 125000000542 sulfonic acid group Chemical group 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 229960001479 tosylchloramide sodium Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/80—Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/12—Iodine, e.g. iodophors; Compounds thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/24—Cyanogen or compounds thereof, e.g. hydrogen cyanide, cyanic acid, cyanamide, thiocyanic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/18—Iodine; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Agronomy & Crop Science (AREA)
- Environmental Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Detergent Compositions (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
包含碘化物和硫氰酸根阴离子、高碘酸以及含氮和/或磷的聚合物的抗微生物组合物。
Description
本发明涉及一种包含碘化物和硫氰酸根阴离子、高碘酸以及含氮和/或磷的聚合物的抗微生物组合物。
包含碘化物和硫氰酸根阴离子以及其它组分如过氧化物酶、过氧化物给体、D-葡萄糖或氧化还原酶的抗微生物组合物是本领域公知的，即公开于WO91/11105、WO95/26137或WO00/01237中。
作为包含碘化物和硫氰酸根阴离子的组合物的其它选择，基于高碘酸(已知为氧化剂和电子受体)的抗微生物组合物是已知的。例如，DE-A-4301277描述了通过在室温下用高碘酸或原高碘酸的0.1-5重量％水溶液处理容器的内表面2-20秒而将高碘酸和/或原高碘酸用于对储存和运输牛奶的容器灭菌。
EP-A-0726357描述了在阴离子纸浆和纸的加工流程中通过水解发酵细菌来抑制挥发性脂肪酸的产生和积累的方法，在该加工流程中监测存在的氢并且加入抗微生物剂和电子受体中的至少一种。对于存在电子受体和要求抑制微生物的情况下，建议使用(仲)高碘酸钠。
WO02/54872公开了包含碘化物和硫氰酸根阴离子以及高碘酸或其盐的混合物的液体抗微生物组合物。此外，该组合物任选包含过氧化物酶，特别是乳过氧化物酶。可以将这些组合物用作杀微生物剂，例如作为可以用于杀病毒和孢子的消毒剂。如果需要，在具体应用中，乳过氧化物酶在体系中的作用是增加体系的保存期和长期效力。
然而，酶是实现这一目标的昂贵方式。此外，由于酶的催化活性，在某些情况下使用酶可能对配制剂中的某些组分造成损害。例如过氧化物酶将会破坏过氧化氢。
因此，本发明所要解决的问题是用更便宜和更不具有破坏性的其它选择来代替酶如过氧化物酶和氧化还原酶。
意外地发现包含氮和/或磷基团的合成聚合物或共聚物适用于实现该目的。与不含有任何聚合物的溶液以及含有不含所述基团的聚合物的溶液相比，当使用该聚合物作为添加剂时保存期和长期效力得到显著增加。
因此，一方面，本发明提供一种液体抗微生物组合物，其中包含：
(1)碘化物阴离子和硫氰酸根阴离子的混合物；
(2)高碘酸或其盐；
和
(3)通过聚合下列物质得到的至少一种聚合物或共聚物：
(a)1-100重量％至少一种包含含氮和/或磷基团的单烯属不饱和单体，
(b)0-99重量％至少一种包含酸性基团(a)的单烯属不饱和共聚单体，
(c)0-99重量％至少一种其它的共聚单体，和
(d)0-5重量％交联共聚单体。
本发明的其它实施方案包括该组合物作为杀微生物剂(例如消毒剂或防腐剂)的用途，以及通过使该组合物与细菌、酵母、真菌、病毒或孢子接触而杀灭或抑制细菌、酵母、真菌、病毒或孢子的方法。
对于本发明，具体说明下列内容：
作为组分(1)，本发明的抗微生物组合物包含碘化物阴离子和硫氰酸根阴离子的混合物。作为其各自的盐提供阴离子。合适的阳离子包括碱金属阳离子、铵离子、
离子和碱土金属阳离子。也可以作为HI提供碘化物。优选作为K盐或Na盐提供阴离子。
在本发明实施方案的组合物中，碘化物∶硫氰酸根阴离子的重量比优选为0.1∶1到50∶1，更优选为0.2∶1到20∶1，最优选为1∶1到3∶1，包括端点。
作为组分(2)，该抗微生物组合物包含高碘酸或其盐。
高碘酸[CAS RN 10450-60-9]，有时指原高碘酸，具有下式：
在高碘酸盐中合适的阳离子包括碱金属离子如Li+、Na+或K+，碱土金属离子如Mg2+或Co2+，铵和烷基铵阳离子如NH3R+、NH2R2 +、NHR3 +和NR4 +，其中R独立地代表有机基团，优选C1-C10烷基或芳烷基。
作为组分(3)，该抗微生物组合物包含上述聚合物或共聚物。
合适的具有含氮基团的单烯属不饱和单体(a)的例子包括含氮丙烯酸衍生物如丙烯酰胺、N-取代的H-丙烯酰胺，或者含氮丙烯酸酯如甲基丙烯酸二甲氨基乙酯，N-乙烯基酰胺如N-乙烯基甲酰胺、N-乙烯基-N-甲基甲酰胺、N-乙烯基乙酰胺、N-乙烯基-N-甲基乙酰胺、N-乙烯基-N-甲基丙酰胺和N-乙烯基丙酰胺。其它的合适单体为N-乙烯基咪唑和在内酰胺环中含有5-13个碳原子的N-乙烯基内酰胺。例子包括N-乙烯基吡咯烷酮、N-乙烯基丁内酰胺、N-乙烯基己内酰胺、N-乙烯基戊内酰胺和N-乙烯基月桂内酰胺。
也可以在聚合后对单体单元改性。如果含氮基团可水解，那么可以将该基团水解。
具有含磷基团的合适单体的例子包括乙烯基膦酸酯。
将这些单体(a)中的至少一种用作组分，即所得聚合物可以是均聚物。然而，优选该聚合物是由至少两种不同单体(a)或者由至少一种单体(a)和至少一种其它单体(b)和/或(c)组成的共聚物。
两种单体(a)的优选组合包括乙烯基咪唑和N-乙烯基吡咯烷酮。
相对于聚合物的总重量，单体(a)在聚合物中的量为1-100重量％。优选该量为5-100重量％，更优选10-60重量％，最优选15-50重量％。
共聚单体(b)包含至少一个酸性基团或其衍生物如盐或酸酐。酸性基团的例子包括-COOH基团、亚磷酸基团、膦酸基团或磺酸基团。
合适共聚单体(b)的例子包括丙烯酸、甲基丙烯酸、马来酸、富马酸、乙烯基磺酸、乙烯基膦酸或亚磷酸单乙烯基酯或亚磷酸单烯丙酯。
优选的单体(b)是丙烯酸、甲基丙烯酸和马来酸。共聚单体(b)的存在量可以为0-99％。优选存在量为0-95％，更优选20-70％，最优选25-65％。
可以使用两种不同类型的共聚单体(c)。一类包括不同于(a)和(b)的单烯属不饱和单体，即不包含含氮或磷基团或酸性基团，但是可通过相同的聚合技术与(a)和(b)共聚的单烯属不饱和单体。
合适的例子包括烯烃如乙烯或丙烯，乙烯基芳族单体如苯乙烯，乙烯醇或其酯如乙酸乙烯酯或丙酸乙烯酯，或者丙烯酸或甲基丙烯酸的酯。
第二类共聚单体(c)不包含烯属不饱和基团，并且该共聚单体不能通过相同的聚合技术与单体(a)和(b)共聚。该共聚单体(c)的例子包括适合形成聚醚的单体，特别是烯化氧如环氧乙烷、环氧丙烷或环氧丁烷，1，ω-二醇如乙二醇、1，3-丙二醇、1，4-丁二醇，或环醚如四氢呋喃(THF)。
优选的共聚单体(c)包括环氧乙烷、环氧丙烷、乙二醇、1，3-丙二醇和1，4-丁二醇。
共聚单体(c)的存在量可以为0-99％，优选为0-75％，更优选为20-70％，最优选为20-60％。
可以通过本领域技术人员已知的任何聚合技术制备所述单体的聚合物和共聚物。优选通过组分(a)、任选的(b)以及任选的第一类单体(c)的自由基聚合而进行聚合。可以在溶液、分散体、悬浮液、乳液或本体中进行聚合。合适的条件是本领域技术人员已知的。
如果使用第二类单体(c)，则必须使用两种不同的聚合技术。首先使用所述单体(c)以形成聚醚，例如通过阳离子聚合或者通过缩聚。优选的聚醚是聚环氧乙烷。第二步，在聚醚存在下通过自由基聚合使单体(a)和任选的(b)发生聚合。在这些条件下，形成接枝聚合物。该技术的详情例如公开于EP-A 1136254及其中引用的文献中。当然，单体(a)和任选的(b)的链段以及单体(c)的链段也可以通过本领域技术人员已知的其它技术相互连接。
作为化合物(d)，该聚合物可以另外包含交联剂；然而，应当避免过度交联。如果存在的话，交联剂的量应当不高于5重量％，优选不高于3％，最优选不高于2％。合适交联剂的例子包含具有两个或更多个非共轭烯属不饱和基团的单体，例如丁二醇二(甲基)丙烯酸酯或己二醇二(甲基)丙烯酸酯。
本领域的技术人员可以通过选择单体(a)和任选的(b)和/或(c)和/或(d)的量和性质而改变本发明使用的聚合物的性质。可以得到水溶性聚合物或油溶性聚合物。
对于本发明而言，优选使用可溶于或至少可分散于水中的聚合物。
本发明的抗微生物组合物可以直接使用或者通过组合/混合各组分的单独溶液而使用。可以将该组合物直接加入(优选在各组分相互剧烈混合后)待保护的介质中。
然而，优选将组合物配制成糊剂、乳剂、溶液或施加在固体载体上。
优选该组合物为液体组合物，并且优选该组合物含有水。
含有水的组合物可以是所有组分在合适的溶剂混合物中的溶液。合适的溶剂混合物优选包含至少50重量％的水，更优选包含至少80％的水，最优选溶剂仅为水。溶剂混合物中的其它组分可以是与水混溶的有机溶剂。合适组分的例子包含一元醇如甲醇、乙醇、1-丙醇或2-丙醇，二元醇如乙二醇或1，4-丁二醇，以及聚醚醇如二甘醇。
该组合物还可以另外含有表面活性剂或乳化剂，以使该组合物为水包油型乳液或基于表面活性剂的溶液。
该组合物还可以含有其它添加剂和助剂，例如染料、缓蚀剂、盐、香料、消泡剂、表面活性剂、乳化剂或螯合剂。
该组合物可以与其它活性剂结合使用，其它活性剂例如为己二酸、苯甲酸、联苯基-2-酚、溴硝丙二醇(bronopol)、次氯酸钙、十六烷基氯化吡啶、氯甲酚、氯二甲酚、D-葡糖酸和N，N”-二(4-氯苯基)-3，12-二亚氨基-2，4，11，13-四氮杂十四烷二脒(2∶1)的化合物、2，2-二溴-2-氰基乙酰胺、乙醇、甲醛、甲酸、戊二醛、2，4-己二烯酸、过氧化氢、碘、1-苯氧基-2-丙醇和2-苯氧基丙醇、L-(+)-乳酸、低聚-(2-(2-乙氧基)乙氧基乙基氯化胍)、五钾二(过一硫酸盐)二(硫酸盐)、过乙酸、2-苯氧基乙醇、邻苯二甲醛、6-(邻苯二甲酰亚氨基)过氧己酸、聚(六亚甲基二胺氯化胍)、(E，E)-2，4-己二烯酸钾、1-丙醇、2-丙醇、季铵化合物(例如苄基-烷基二甲基氯化铵、[2-[[2-[(2-羧乙基)(2-羟乙基)氨基]乙基]氨基]-2-氧代乙基]椰油烷基二甲基氢氧化铵、苄基-C12-14烷基二甲基氯化铵、苄基-C12-16烷基二甲基氯化铵、苄基-C12-18烷基二甲基氯化铵、C12-14烷基[(乙基苯基)甲基]二甲基氯化铵、n-C10-16烷基三亚甲基二胺和氯乙酸的反应产物、二C8-10烷基二甲基氯化铵、二烷基(C8-18)二甲基铵化合物、二癸基二甲基氯化铵、十六烷基氯化吡啶、谷氨酸和N-(C12-14烷基)丙二胺的反应产物)、水杨酸、氯化银或其它银盐、2-联苯酚钠、二氯异氰脲酸钠二水合物、二氯-异三聚氰酸钠(sodiumdichloro-s-triazinetrione)、次氯酸钠、对氯间甲酚钠、氯胺T钠(sodiumtosylchloramide)。
优选的可联用产品为氯甲酚、氯二甲酚、乙醇、甲醛、甲酸、戊二醛、过氧化氢、1-苯氧基-2-丙醇和2-苯氧基丙醇、2-苯氧基乙醇、邻苯二甲醛、聚六亚甲基双胍、1-丙醇、2-丙醇或上述季铵化合物。
本发明实施方案的组合物可以作为抗微生物剂，例如作为防腐剂或作为消毒剂。
特别是，本发明实施方案的组合物在抵抗细菌、酵母、真菌、病毒和孢子如杆菌孢子时特别有效。
典型应用浓度为：
| 组分 | 典型浓度 | 优选 |
| 高碘酸或其盐 | 0.01-100mmol/l | 0.05-10mmol/l |
| 碘化物离子 | 0.005-50mmol/l | 0.05-10mmol/l |
| 硫氰酸根离子 | 0.005-50mmol/l | 0.05-10mmol/l |
| (共)聚合物 | 0.005-10重量％ | 0.1-5重量％ |
当然也可以作为浓缩物配制组合物并在使用前将其稀释。各组分可以配制成单独的浓缩物。以同样的方式，可以将浓缩物或组分浓缩物加入待保护的介质中以达到上述浓度。
该组合物的pH值可以为1-8，但优选小于6.0，特别是在低pH值下，该组合物可以包含游离的高碘酸。然而，该组合物可作为其它选择而包含或额外包含碱金属，特别是钠及其盐。可以使用合适的缓冲体系调节pH值。
可以使用该组合物的应用领域是：皮肤消毒剂，抗微生物皂，晒黑剂，医疗设备的消毒，游泳池等的处理，空气调节加工，人类居所的卫生，化学盥洗用品，污水/废水处理，医院传染性废水和污物或其他物质的处理，洗衣，动物的窝/棚/机器/鞋袜、孵化器、运输设备的消毒，鱼类养殖，食品加工厂的地板、墙壁和设备，无菌包装材料的制造。
除了将组合物用作抗微生物剂(例如作为上述的防腐剂或消毒剂)之外，本发明实施方案的抗微生物组合物可以在要求有效抗病毒、抗菌、抗霉菌和/或抗酵母活性的各种产品中提供活性组分。这类产品的例子包括：
(a)除臭剂，例如以洗液的形式局部给药；
(b)抗菌皮肤洗涤液，例如以洗剂形式；
(c)抗痤疮制剂，例如以洗剂或乳膏形式；
(d)抗足癣制剂，例如以洗剂形式；
(e)去头屑制剂，例如以香波或洗剂形式；
(f)牙科制剂，例如适合一般口腔卫生的漱口剂，特别是具有抗牙菌斑性质的那些，以及洁齿剂如牙膏、口香糖和糖锭；
(g)浸渍材料，例如伤口包扎材料、缝合线和牙线；
(h)药物，例如伤口冲洗剂和灼伤治疗剂、抗腹泻剂以及适合治疗传染病如假丝酵母和癣菌传染病的药物；
(i)眼科制剂，例如洗眼剂和/或隐形眼镜消毒液；和
(j)杀菌剂，例如用于乳瓶和外科或牙科器械。
另一方面，本发明提供了一种杀灭或抑制病毒或孢子的方法，该方法包含使上述组合物与病毒或孢子接触。
可以通过处理待保护的目标而使用本发明实施方案的组合物，例如用该组合物处理医疗设备等。这例如可以通过将目标浸入溶液或将溶液喷雾到目标上来完成。
此外，可以将该组合物加入待保护的介质中。在后者的情况下，可以使用所有组分的溶液，然而当然也可以单独加入各组分；即，盐溶液和聚合物溶液。对于本发明的范围，仅需要所有组分都存在于待保护的介质中。
现在参考下列实施例更详细描述本发明实施方案。
实施例
对于所有的实施例和对比例，使用NaSCN、NaI和高碘酸的水溶液(pH值3.8)。
所有样品的浓度为：0.9mmol/l高碘酸盐、0.4mmol/l碘化物和0.6mmol/l硫氰酸盐。
以表1所示的浓度将聚合物加入每一个所述溶液中。为了对比，其中一个样品中没有加入任何聚合物。
通过将所有的组分溶解于水中得到要求的浓度而制备表1中总结的样品。将溶液储存在室温下，并且在表1所述的储存时间点进行试验。测试程序包含对储存溶液取样，并且用表1所述的生物体进行接种。如果与溶液接触5分钟后显示生物体减少5个对数值，那么溶液符合阳性结果的测试标准。
所有实验总结在表1中。
备注+有效。混合物在储存一个月后，黑曲霉和大肠杆菌在5分钟内减少至少5个对数值
-无效。混合物在储存一个月后，黑曲霉和大肠杆菌在5分钟内减少小于5个对数值
实施例和对比例清楚地说明了使用包含含N或P基团的聚合物显著提高了稳定性和长期活性。不含所述基团的聚合物没有表现出这样的效果。
Claims (7)
1.一种抗微生物组合物，其中包含：
(1)0.005-50mmol/l的碘化物阴离子和0.005-50mmol/l的硫氰酸根阴离子的混合物，其中碘化物阴离子与硫氰酸根阴离子的重量比为0.2∶1到20∶1，
(2)0.01-100mmol/l的高碘酸或其盐，和
(3)0.005-10重量％的至少一种含有下列单元的聚合物或共聚物
(a)5-100重量％至少一种包含含氮基团的单烯属不饱和单体，该单体选自：含氮丙烯酸衍生物，N-乙烯基酰胺，N-乙烯基咪唑和在内酰胺环中含有5-13个碳原子的N-乙烯基内酰胺，
(b)0-95重量％至少一种包含酸性基团的单烯属不饱和共聚单体，该单体选自：丙烯酸、甲基丙烯酸、马来酸、富马酸、乙烯基磺酸、乙烯基膦酸、亚磷酸单乙烯基酯或亚磷酸单烯丙酯，
(c)0-75重量％至少一种选自如下的共聚单体，
-不同于(a)和(b)的单烯属不饱和单体，和
-适合形成聚醚的不包含烯属不饱和基团的单体，
和
(d)0-5重量％的包含两个或更多个非共轭烯属不饱和基团的交联共聚单体。
2.根据权利要求1的组合物，其中共聚物单元的量为：
(a)10-60％，
(b)20-70％，
(c)0-70％，和
(d)0-5％。
3.根据权利要求1或2的组合物，其中该组合物为液体组合物。
4.根据权利要求3的组合物，其中该组合物的溶剂包含水。
5.根据权利要求1的组合物，其中所述共聚物包含乙烯基咪唑和N-乙烯基吡咯烷酮作为单体(a)。
6.根据权利要求1-5中任一项的组合物作为皮肤消毒剂，抗微生物皂，晒黑剂，医疗设备的消毒，游泳池的处理，空气调节加工，人类居所的卫生，化学盥洗用品，污水、废水处理，医院传染性废水和污物的处理，洗衣，动物的窝、棚、鞋袜、孵化器、运输设备的消毒，鱼类养殖，食品加工厂的地板、墙壁和设备，或无菌包装材料的制造用杀微生物剂的用途。
7.根据权利要求1-5中任一项的组合物作为除臭剂，抗菌皮肤洗涤液，抗痤疮制剂，抗足癣制剂或去头屑制剂中的活性组分的用途。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0328156.5 | 2003-12-04 | ||
| GBGB0328156.5A GB0328156D0 (en) | 2003-12-04 | 2003-12-04 | Antimicrobial compositions comprising polymeric stabilizers |
| PCT/EP2004/013606 WO2005053398A1 (en) | 2003-12-04 | 2004-12-01 | Antimicrobial compositions comprising polymeric stabilizers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1889829A CN1889829A (zh) | 2007-01-03 |
| CN1889829B true CN1889829B (zh) | 2011-05-04 |
Family
ID=29764600
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2004800360853A Expired - Fee Related CN1889829B (zh) | 2003-12-04 | 2004-12-01 | 包含聚合稳定剂的抗微生物组合物 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7479476B2 (zh) |
| EP (1) | EP1711056B1 (zh) |
| JP (1) | JP4689619B2 (zh) |
| KR (1) | KR101161059B1 (zh) |
| CN (1) | CN1889829B (zh) |
| AT (1) | ATE487379T1 (zh) |
| AU (1) | AU2004294286B2 (zh) |
| BR (1) | BRPI0417102A (zh) |
| CA (1) | CA2545609A1 (zh) |
| DE (1) | DE602004030046D1 (zh) |
| ES (1) | ES2356247T3 (zh) |
| GB (1) | GB0328156D0 (zh) |
| MX (1) | MXPA06005992A (zh) |
| RU (1) | RU2340182C2 (zh) |
| WO (1) | WO2005053398A1 (zh) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080081020A1 (en) * | 2006-10-03 | 2008-04-03 | Huang Yeong H | Color change surgical prep solution |
| GB0907553D0 (en) * | 2009-05-01 | 2009-06-10 | Insense Ltd | Treatment of human or animal body surface infection |
| WO2012017006A2 (en) * | 2010-08-06 | 2012-02-09 | Basf Se | Use of a n-vinyllactam / vinylimidazol copolymer as dispersing agent |
| US9226499B2 (en) * | 2010-12-17 | 2016-01-05 | Dow Global Technologies Llc | Protected antimicrobial compounds for high temperature applications |
| US9717657B2 (en) | 2012-10-24 | 2017-08-01 | Amy Dukoff | Composition and method of using medicament for endodontic irrigation, stem cell preparations and tissue regeneration |
| EP2987408A1 (en) * | 2014-08-20 | 2016-02-24 | National University of Ireland, Galway | Iodophor composition with improved stability in the presence of organic material |
| DE102016102485A1 (de) * | 2016-02-12 | 2017-08-17 | Sven Reichwagen | Desinfektionsmittel |
| EP3439472A1 (en) | 2016-04-04 | 2019-02-13 | Higher Dimension Materials, Inc. | Antimicrobial fabric assemblies |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1323527A (zh) * | 2000-05-16 | 2001-11-28 | 顾浩 | 银、铜无机抗菌剂 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9002422D0 (en) * | 1990-02-03 | 1990-04-04 | Boots Co Plc | Anti-microbial compositions |
| DE4301277A1 (de) | 1993-01-11 | 1994-07-14 | Stubinitzky Heinz Guenter | Verfahren zur Sterilisierung von Anlagen für die Milchbehandlung |
| GB9406075D0 (en) | 1994-03-26 | 1994-05-18 | Boots Co Plc | Method of killing microorganisms |
| DE4414254A1 (de) | 1994-04-23 | 1995-10-26 | Basf Ag | Iodophor aus Poly-N-vinyllactam und Dextrin |
| AU4219496A (en) | 1995-02-07 | 1996-08-15 | Betz Laboratories, Inc. | Inhibiting anaerobic production of volatile fatty acids and hydrogen by bacteria |
| US5643608A (en) * | 1996-03-01 | 1997-07-01 | West Agro, Inc. | Low pH germicidal iodine compositions having enhanced stability |
| US6153229A (en) * | 1997-04-02 | 2000-11-28 | West Agro, Inc. | Stable glycerine iodine concentrate compositions |
| GB9814547D0 (en) | 1998-07-06 | 1998-09-02 | Knoll Ag | Sporicidal composition |
| DE19944464A1 (de) * | 1999-09-16 | 2001-03-22 | Basf Ag | Verfahren zur Herstellung von Polyvinylpyrrolidon-lod in wässriger Lösung |
| EP1136254B1 (de) | 2000-03-23 | 2003-05-28 | BASF Drucksysteme GmbH | Verwendung von Pfropfcopolymeren zur Herstellung lasergravierbarer Reliefdruckelementen |
| GB0100643D0 (en) * | 2001-01-10 | 2001-02-21 | Basf Ag | Liquid antimicrobial compositions |
-
2003
- 2003-12-04 GB GBGB0328156.5A patent/GB0328156D0/en not_active Ceased
-
2004
- 2004-12-01 AU AU2004294286A patent/AU2004294286B2/en not_active Ceased
- 2004-12-01 US US10/581,007 patent/US7479476B2/en not_active Expired - Fee Related
- 2004-12-01 RU RU2006123437/15A patent/RU2340182C2/ru not_active IP Right Cessation
- 2004-12-01 DE DE602004030046T patent/DE602004030046D1/de active Active
- 2004-12-01 MX MXPA06005992A patent/MXPA06005992A/es active IP Right Grant
- 2004-12-01 CA CA002545609A patent/CA2545609A1/en not_active Abandoned
- 2004-12-01 ES ES04803381T patent/ES2356247T3/es active Active
- 2004-12-01 WO PCT/EP2004/013606 patent/WO2005053398A1/en active Application Filing
- 2004-12-01 AT AT04803381T patent/ATE487379T1/de not_active IP Right Cessation
- 2004-12-01 CN CN2004800360853A patent/CN1889829B/zh not_active Expired - Fee Related
- 2004-12-01 KR KR1020067013024A patent/KR101161059B1/ko not_active IP Right Cessation
- 2004-12-01 JP JP2006541873A patent/JP4689619B2/ja not_active Expired - Fee Related
- 2004-12-01 EP EP04803381A patent/EP1711056B1/en not_active Not-in-force
- 2004-12-01 BR BRPI0417102-0A patent/BRPI0417102A/pt not_active Application Discontinuation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1323527A (zh) * | 2000-05-16 | 2001-11-28 | 顾浩 | 银、铜无机抗菌剂 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005053398A1 (en) | 2005-06-16 |
| JP2007513109A (ja) | 2007-05-24 |
| AU2004294286A1 (en) | 2005-06-16 |
| ES2356247T3 (es) | 2011-04-06 |
| KR20060123405A (ko) | 2006-12-01 |
| MXPA06005992A (es) | 2006-08-23 |
| GB0328156D0 (en) | 2004-01-07 |
| RU2006123437A (ru) | 2008-01-20 |
| DE602004030046D1 (de) | 2010-12-23 |
| AU2004294286B2 (en) | 2009-12-24 |
| CN1889829A (zh) | 2007-01-03 |
| BRPI0417102A (pt) | 2007-02-06 |
| US7479476B2 (en) | 2009-01-20 |
| KR101161059B1 (ko) | 2012-06-29 |
| JP4689619B2 (ja) | 2011-05-25 |
| US20070111915A1 (en) | 2007-05-17 |
| ATE487379T1 (de) | 2010-11-15 |
| RU2340182C2 (ru) | 2008-12-10 |
| EP1711056A1 (en) | 2006-10-18 |
| CA2545609A1 (en) | 2005-06-16 |
| EP1711056B1 (en) | 2010-11-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9034390B2 (en) | Anti-microbial composition and method for making and using same | |
| KR100449283B1 (ko) | 소독 또는 멸균을 위한 산소활성 제조물 | |
| US6436445B1 (en) | Antimicrobial and antiviral compositions containing an oxidizing species | |
| JP2008543850A (ja) | 水性系および物体上における微生物の成育を抑制する方法および組成物 | |
| ES2938638T3 (es) | Composición biocida para uso en un proceso de lavado de prendas de vestir | |
| US20140134224A1 (en) | Stable composition of hoci, a process for its production and uses thereof | |
| US20070264355A1 (en) | Binary compositions and methods for sterilization | |
| US20040183050A1 (en) | Composition for the production of chlorine dioxide using non-iodo interhalides or polyhalides and methods of making and using the same | |
| US5186946A (en) | Disinfectant with wide spectrum germicidal activity | |
| CN1889829B (zh) | 包含聚合稳定剂的抗微生物组合物 | |
| US20060257498A1 (en) | Antimicrobial combination of amine and oxygen compounds | |
| JP3944080B2 (ja) | 液状抗菌組成物 | |
| JP4228175B2 (ja) | 殺菌剤組成液及び殺菌方法 | |
| CA2062006C (en) | Disinfectant with wide spectrum germicidal activity | |
| AU2002217319A1 (en) | Liquid antimicrobial compositions | |
| EP0799570A1 (en) | Preparation and uses of microbicidal formulations | |
| GB2292888A (en) | Wide spectrum water soluble biocide for medical instruments based on potassium monoperoxysulphate, malic & sulphamic acids, EDTA sodium salt & a glycol ether | |
| JP2002145710A (ja) | 殺菌剤組成物 | |
| CN111602667A (zh) | 一种多用途生物安全消毒剂 | |
| IE54238B1 (en) | Stabilized iodine-containing germicidal preparation | |
| JP2019511470A (ja) | 殺菌剤 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110504 Termination date: 20131201 |