AU2002217319A1 - Liquid antimicrobial compositions - Google Patents
Liquid antimicrobial compositionsInfo
- Publication number
- AU2002217319A1 AU2002217319A1 AU2002217319A AU2002217319A AU2002217319A1 AU 2002217319 A1 AU2002217319 A1 AU 2002217319A1 AU 2002217319 A AU2002217319 A AU 2002217319A AU 2002217319 A AU2002217319 A AU 2002217319A AU 2002217319 A1 AU2002217319 A1 AU 2002217319A1
- Authority
- AU
- Australia
- Prior art keywords
- composition
- composition according
- weight
- iodide
- anions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Description
Liquid Antimicrobial Compositions
This invention relates to an antimicrobial composition comprising iodide and thiocyanate anions.
Particular compositions of this type are disclosed in WO- A-91/11105. These compositions comprise
(1) iodide and thiocyanate anions in a weight : eight (I~:SCN~) ratio of 0.1:1 to 50:1 and in a combined anion weight concentration of at least 5mg/kg;
(2) D-glucose in a weight concentration of at least 0.2g/kg;
(3) glucose oxidase as an oxidoreductase enzyme; and
(4) optionally, a peroxidase, especially lactoperoxidase.
Preferred such compositions of WO-A-91/11105 are preservative compositions in a solid (dry powder) , or liquid two-pack, form in which one pack contains the D- glucose and the other the glucose oxidase. The contents of the two packs are mixed and immediately used.
On the other hand WO-A-95/26137 describes antimicrobial compositions containing the same components as those of WO-A-91/11105 and preferably in the same proportions.
However, WO-A-95/26137 does not recommend the immediate use of components mixed together; rather, it teaches the provision of an incubation period of from 12 - 48 hours before use. From this, it is clear that in order to achieve an antimicrobial effect using such compositions, it is necessary to allow the components to react with one
another to form a reaction product which then has the desired rapid antimicrobial activity.
As an alternative to compositions containing iodide and thiocyanate anions, antimicrobial compositions are known which are based on periodic acid, which is a known oxidising agent and electron acceptor. For example, DE-A- 4301277 describes the use of periodic and/or orthoperiodic acid for the sterilisation of containers for storage and transportation of milk by treating the internal surfaces of the container at room temperature for 2 - 20 seconds with an aqueous solution of 0.1 to 5 wt% of periodic or orthoperiodic acid.
EP-A-0726357 describes a process for inhibiting the production and accumulation of volatile fatty acids by hydrolytic fermentative bacteria in an anionic pulp and paper processing stream in which the presence of hydrogen is monitored and at least one of a biocide and an electron acceptor is added. The use of sodium (para) periodate is recommended for the case where the presence of an electron acceptor and some inhibition of the microorganisms is required.
We have now found surprisingly that if, in an antimicrobial composition containing iodide and thiocyanate ions, D-glucose and glucose oxidase (such as a composition described in WO-A-91/11105 or WO-A- 95/26137), the D-glucose and glucose oxidase in combination are replaced solely by periodic acid or an alkali metal salt thereof, an efficient liquid antimicrobial composition is obtained, which is capable
of having a rapid killing effect upon the microorganisms which it is used to treat.
Thus, according to one aspect, the invention provides a liquid antimicrobial composition comprising
(1) a mixture of iodide anions and thiocyanate anions;
(2) periodic acid or an alkali metal salt thereof; and (3) optionally, a peroxidase.
Periodic acid [CAS RN 10450-60-9] , sometimes referred to an orthoperiodic acid, has the formula
Preferably, the periodic acid or salt thereof is present in the composition in an amount of from 25 to 500 ppm, more preferably from 200 to 500 ppm, by weight of the total weight of the composition.
Thus, even a composition containing as low an amount of periodic acid as 25 - 50 ppm can kill bacteria such as E.coli but for a broad spectrum of activity, the minimum amount should be about 100 ppm. Moreover, for a stable shelf life, at least 200 ppm is preferred. The preferred maximum amount is about 500 ppm.
Such compositions react considerably faster than the composition disclosed in WO-A-91/11105 and WO-A-95/26137
so that, instead of the 4 - 48 hours recommended for optimum potency, compositions embodying the invention may achieve a rapid kill of microorganisms immediately after mixing .
In contrast to the two-pack forms disclosed in WO-A- 91/11105 and WO-A-95/26137 for use as a preservative, a liquid composition embodying the invention can be used as a disinfectant, in the form of a single, ready to use, product .
The spectrum of antimicrobial activity is also somewhat different from that of the abovementioned known compositions. In particular, compositions embodying the invention are particularly effective in combatting viruses and spores, e.g. bacillus spores.
The precise role played by the periodic acid in improving the antimicrobial efficiency of the iodide/thiocyanate anion system is not fully understood, although the mechanism seems to involve oxidation.
The pH of the composition may be from, say, 1 to 8 but is preferably less than 4.5 and, especially at low pH, the composition may contain free periodic acid. However, the composition may alternatively or additionally contain an alkali metal, especially the sodium, salt thereof.
As indicated above, the composition may additionally contain a peroxidase, especially lactoperoxidase; the presence of a peroxidase is surprisingly found to improve the shelf life of the composition. Thus, although this
might have been expected for an organic oxidation/reduction system as in WO-A-91/11105, it is surprising that such an effect is. achievable with an inorganic system utilizing periodic acid.
Preferably the peroxidase is present in the composition in an amount of at least 10 U/kg.
In a composition embodying the invention, the weight :weight ratio of iodide: thiocyanate anions is preferably from 0.1:1 to 50:1, more preferably from 0.2:1 to 20:1 inclusive.
The iodide and thiocyanate anions are preferably present in the composition in a total amount of at 'least 5 mg/kg, based on the total weight of the composition. The iodide anions are preferably present in the composition at a weight concentration of at least 5 mg/kg, while the thiocyanate ions are preferably present at a weight concentration of at least 2 mg/kg, based on the total weight of the composition.
A composition embodying the invention may contain additionally a suitable carrier. Preferably, the carrier is water and the composition is an aqueous solution. However, the carrier may comprise water and, additionally, a surfactant or emulsifier, whereby the composition is an oil in water emulsifier or a surfactant based solution.
According to other aspects, the invention provides the use of a composition as defined above as a microbicide or
as a disinfectant respectively and especially the use of such a composition for suppressing or killing viruses or spores, e.g. bacillus spores.
In addition to the use of the composition as a microbicide or disinfectant, an anti-microbial composition embodying the invention may provide the active component in a wide variety of products which require potent antibacterial, anti-mould and/or anti- yeast activities. Examples of such products include:
a) deodorants e.g. for topical administration in the form of lotions;
b) antibacterial skin washes e.g. in the forms of lotions;
c) anti-acne preparations e.g. in the form of lotions or creams ;
d) anti-athletes foot preparations e.g. in the form of lotions ;
e) anti-dandruff preparations e.g. in the form of shampoos or lotions;
f) dental preparations, e.g. mouth washes suitable for general oral hygiene and, in particular, having anti- plaque properties, and dentrifices such as toothpastes, chewing gums and lozenges;
g) impregnated materials e.g. wound dressings, sutures and dental floss;
h) pharmaceuticals e.g. wound irrigants and burn treatments, anti-diarrhoeal agents and medicaments suitable for the treatment of infections such as Candida and Tinea infections;
i) opthal ic preparations e.g. eye washes and/or sterilising contact lenses; and
j) sterilants e.g. for baby bottles and surgical or dental instruments.
According to yet another aspect, the invention provides a method of killing or suppressing viruses or spores comprising contacting them within a composition as defined above .
Embodiments of the invention will now be described in more detail with reference to the following Examples.
Example
A composition contains
1. NaSCN 4.2 mg
2. KI 7.3 mg
3. Lactoperoxidase 70 international units 4. Periodic acid 200 mg
5. Water up to 100 ml.
Components 1 - 4 were added to 75 mis of distilled water and stirred until dissolved. The solution was then made up to 100 mis with distilled water.
The above solution was then immediately challenged with a lxlO6 cfu/ml inoculum of the following organisms.
Ps .aeruginosa NCIB 8626 S.aureus NCIB 9518 E.coli NCIB 8545
C.albicans ATCC 1023 A. niger ATCC 16404
Total kill of each of the above organisms was achieved in less than 5 mins .
Excellent anti-viral activity was also demonstrated against Echovirus 11 and Herpes simplex virus type 1 (HSV-1) .
Excellent sporicidal activity was also demonstrated against B.cereus NCTC 2599 and B.subtilis NCTC 10073.
The solution was still demonstrating the above activity after six months storage at room temperature.
Claims (17)
1. A liquid antimicrobial composition comprising:
(1) a mixture of iodide anions and thiocyanate anions;
(2) periodic acid or an alkali metal salt thereof; and
(3) optionally, a peroxidase.
2. . A composition according to claim 1, wherein the periodic acid or salt thereof is present in the composition in an amount of from 25 to 500 ppm by weight of the total weight of the composition.
3. A composition according to claim 2, wherein the periodic acid or salt thereof is present in an amount of from 200 to 500 ppm by weight of the total weight of the composition.
4. A composition according to any preceding claim, wherein the weight :weight ratio of iodide: thiocyanate anions is from 0.1:1 to 50:1 inclusive.
5. A composition according to claim 4, wherein the weight : eight ratio of iodide: thiocyanate anions is from 0.2:1 to 20:1 inclusive.
6. A composition according to any preceding claim, wherein the iodide and thiocyanate anions are present in the composition in a total weight of at least 5 mg/kg, based on the total weight of the composition.
7. A composition according to any preceding claim, wherein the iodide anions are present in the composition to a weight concentration of at least 5 mg/kg and the thiocyanate ions to a weight concentration of at least 2 mg/kg, based on the total weight of the composition.
8. A composition according to any preceding claim, which contains a peroxidase.
9. A composition according to claim 8, wherein the peroxidase is lactoperoxidase.
10. A composition according to claim 8 or claim 9, wherein the peroxidase is present in the composition in an amount of at least 10 U/kg.
11. A composition according to any preceding claim which additionally contains a suitable carrier.
12. A composition according to claim 11, wherein the carrier is water and the composition is an aqueous solution.
13. A composition according to claim 12, wherein the carrier additionally comprises a surfactant or emulsifier and the composition is an oil in water emulsifier or a surfactant based solution.
14. Use of a composition according to any preceding claim as a microbicide.
15. Use of a composition according to any one of claims 1 to 13 as a disinfectant.
16. Use of a composition according to any one of claim 1 to 14 for suppressing or killing viruses or spores.
17. A method of killing or suppressing viruses or spores comprising contacting them with a composition according to any one of claims 1 to 13.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0100643.6A GB0100643D0 (en) | 2001-01-10 | 2001-01-10 | Liquid antimicrobial compositions |
GB0100643.6 | 2001-01-10 | ||
PCT/GB2002/000025 WO2002054872A1 (en) | 2001-01-10 | 2002-01-04 | Liquid antimicrobial compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
AU2002217319A1 true AU2002217319A1 (en) | 2003-02-06 |
AU2002217319B2 AU2002217319B2 (en) | 2006-10-05 |
Family
ID=9906582
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2002217319A Ceased AU2002217319B2 (en) | 2001-01-10 | 2002-01-04 | Liquid antimicrobial compositions |
Country Status (16)
Country | Link |
---|---|
US (1) | US6866869B2 (en) |
EP (1) | EP1349457B1 (en) |
JP (1) | JP3944080B2 (en) |
KR (1) | KR100837194B1 (en) |
CN (1) | CN1258327C (en) |
AT (1) | ATE333796T1 (en) |
AU (1) | AU2002217319B2 (en) |
BR (1) | BR0206262B1 (en) |
CA (1) | CA2436808C (en) |
DE (1) | DE60213361T2 (en) |
DK (1) | DK1349457T3 (en) |
ES (1) | ES2269689T3 (en) |
GB (1) | GB0100643D0 (en) |
MX (1) | MXPA03005740A (en) |
PT (1) | PT1349457E (en) |
WO (1) | WO2002054872A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD2069C2 (en) * | 2001-08-30 | 2003-06-30 | Неогаленафарм, С.Р.Л. | Antiseptic preparation and process for obtaining thereof |
GB0328156D0 (en) * | 2003-12-04 | 2004-01-07 | Basf Ag | Antimicrobial compositions comprising polymeric stabilizers |
GB0413954D0 (en) * | 2004-06-22 | 2004-07-28 | Altunkaya Ali | Compositions for topical treatment |
CA2504014C (en) * | 2005-04-13 | 2013-06-18 | Siamons International Inc. | Non-toxic water soluble inorganic anti-microbial polymer and related methods |
AU2007307921B2 (en) * | 2006-10-10 | 2013-03-28 | Laclede, Inc. | Methods and compositions for the treatment of vaginal diseases employing peroxide-producing enzymes and peroxidases |
EP2987408A1 (en) * | 2014-08-20 | 2016-02-24 | National University of Ireland, Galway | Iodophor composition with improved stability in the presence of organic material |
FR3041269B1 (en) * | 2015-09-17 | 2020-04-17 | Taradon Laboratory | COMPOSITION COMPRISING I2SCN- AND / OR IONS I (SCN) 2- |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9002422D0 (en) * | 1990-02-03 | 1990-04-04 | Boots Co Plc | Anti-microbial compositions |
DE4301277A1 (en) * | 1993-01-11 | 1994-07-14 | Stubinitzky Heinz Guenter | Sterilising containers and plant for milk and milk prods. |
GB9406075D0 (en) | 1994-03-26 | 1994-05-18 | Boots Co Plc | Method of killing microorganisms |
US5908614A (en) * | 1995-08-15 | 1999-06-01 | Montgomery; Robert Eric | Peroxidase-activating oral compositions |
US5972355A (en) * | 1997-09-30 | 1999-10-26 | E-L Management Corp. | Stable compositions containing biologically active components |
-
2001
- 2001-01-10 GB GBGB0100643.6A patent/GB0100643D0/en not_active Ceased
-
2002
- 2002-01-04 JP JP2002555622A patent/JP3944080B2/en not_active Expired - Fee Related
- 2002-01-04 MX MXPA03005740A patent/MXPA03005740A/en active IP Right Grant
- 2002-01-04 WO PCT/GB2002/000025 patent/WO2002054872A1/en active IP Right Grant
- 2002-01-04 AU AU2002217319A patent/AU2002217319B2/en not_active Ceased
- 2002-01-04 EP EP02729365A patent/EP1349457B1/en not_active Expired - Lifetime
- 2002-01-04 DE DE60213361T patent/DE60213361T2/en not_active Expired - Lifetime
- 2002-01-04 KR KR1020037009075A patent/KR100837194B1/en not_active IP Right Cessation
- 2002-01-04 BR BRPI0206262-3A patent/BR0206262B1/en not_active IP Right Cessation
- 2002-01-04 DK DK02729365T patent/DK1349457T3/en active
- 2002-01-04 ES ES02729365T patent/ES2269689T3/en not_active Expired - Lifetime
- 2002-01-04 CN CNB028035690A patent/CN1258327C/en not_active Expired - Fee Related
- 2002-01-04 CA CA2436808A patent/CA2436808C/en not_active Expired - Fee Related
- 2002-01-04 PT PT02729365T patent/PT1349457E/en unknown
- 2002-01-04 AT AT02729365T patent/ATE333796T1/en active
- 2002-01-04 US US10/250,566 patent/US6866869B2/en not_active Expired - Fee Related
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