CN1886389B - 喹喔啉化合物 - Google Patents

喹喔啉化合物 Download PDF

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Publication number
CN1886389B
CN1886389B CN2004800348033A CN200480034803A CN1886389B CN 1886389 B CN1886389 B CN 1886389B CN 2004800348033 A CN2004800348033 A CN 2004800348033A CN 200480034803 A CN200480034803 A CN 200480034803A CN 1886389 B CN1886389 B CN 1886389B
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independently
alkyl
members
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Chinese (zh)
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CN1886389A (zh
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J·P·爱德华兹
J·D·维纳布尔
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
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    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
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    • A61P27/16—Otologicals
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    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • A—HUMAN NECESSITIES
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    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
    • C07D241/52—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
CN2004800348033A 2003-09-30 2004-09-29 喹喔啉化合物 Expired - Fee Related CN1886389B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50717603P 2003-09-30 2003-09-30
US60/507,176 2003-09-30
PCT/US2004/032003 WO2005033088A1 (en) 2003-09-30 2004-09-29 Quinoxaline compounds

Publications (2)

Publication Number Publication Date
CN1886389A CN1886389A (zh) 2006-12-27
CN1886389B true CN1886389B (zh) 2010-07-21

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Family Applications (1)

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CN2004800348033A Expired - Fee Related CN1886389B (zh) 2003-09-30 2004-09-29 喹喔啉化合物

Country Status (11)

Country Link
US (1) US20050070527A1 (OSRAM)
EP (1) EP1670774A1 (OSRAM)
JP (1) JP2007507514A (OSRAM)
KR (1) KR20060111466A (OSRAM)
CN (1) CN1886389B (OSRAM)
AU (2) AU2004278372B2 (OSRAM)
CA (1) CA2540638A1 (OSRAM)
IL (1) IL174629A0 (OSRAM)
MX (1) MXPA06003578A (OSRAM)
WO (1) WO2005033088A1 (OSRAM)
ZA (1) ZA200603410B (OSRAM)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0525068D0 (en) 2005-12-08 2006-01-18 Novartis Ag Organic compounds
BRPI0710083A2 (pt) 2006-03-31 2011-08-02 Janssen Pharmaceutica Nv entidade quìmica benzoimidazol-2-il pirimidina e pirazina, composição farmacêutica e uso destas
US20090069343A1 (en) * 2006-04-10 2009-03-12 Dunford Paul J Combination Histamine H1R and H4R Antagonist Therapy for Treating Pruritus
CA2657702A1 (en) * 2006-07-03 2008-01-10 Vereniging Voor Christelijk Hoger Onderwijs Wetenschappelijk Onderzoek E N Patieentenzorg Quinazolines and related heterocyclic comp0unds, and their therapeutic use
GB0614471D0 (en) 2006-07-20 2006-08-30 Syngenta Ltd Herbicidal Compounds
US7985745B2 (en) 2006-10-02 2011-07-26 Abbott Laboratories Method for pain treatment
EP2077263A1 (en) * 2008-01-02 2009-07-08 Vereniging voor christelijk hoger onderwijs, wetenschappelijk onderzoek en patiëntenzorg Quinazolines and related heterocyclic compounds and their therapeutic use
NZ589531A (en) * 2008-06-12 2012-08-31 Janssen Pharmaceutica Nv Use of histamine H4 antagonist for the treatment of post-operative tissue adhesions after surgical procedures
US9371311B2 (en) 2008-06-30 2016-06-21 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine derivatives
EP2201982A1 (en) 2008-12-24 2010-06-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Histamine H4 receptor antagonists for the treatment of vestibular disorders
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
CN102762572A (zh) 2010-02-01 2012-10-31 诺瓦提斯公司 作为CRF-1受体拮抗剂的吡唑并[5,1b]*唑衍生物
WO2011092293A2 (en) 2010-02-01 2011-08-04 Novartis Ag Cyclohexyl amide derivatives as crf receptor antagonists
CN102753527B (zh) 2010-02-02 2014-12-24 诺华股份有限公司 用作crf受体拮抗剂的环己基酰胺衍生物
UY34094A (es) 2011-05-27 2013-01-03 Novartis Ag Derivados de la piperidina 3-espirocíclica como agonistas de receptores de la ghrelina
EA201491990A1 (ru) 2012-05-03 2015-02-27 Новартис Аг L-малатная соль 2,7-диазаспиро[4.5]дец-7-иловых производных и их кристаллические формы в качестве агонистов грелиновых рецепторов
SI2858647T1 (sl) 2012-06-08 2018-11-30 Sensorion Inhibitorji receptorja H4 za zdravljenje tinitusa
HUE047681T2 (hu) 2013-03-06 2020-05-28 Janssen Pharmaceutica Nv A hisztamin H4 receptor benzimidazol-2-il-pirimidin modulátorai
CN105001169B (zh) * 2015-07-09 2017-07-21 华侨大学 一种3‑氨基喹喔啉‑2(1h)‑酮类化合物的合成方法
CN110092760B (zh) * 2019-06-04 2020-11-13 杭州师范大学 一种3-氟代烷氧基-2(1h)-喹喔啉酮及其合成方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3493572A (en) * 1968-07-05 1970-02-03 Pfizer & Co C Process for producing quinoxaline-di-n-oxides
GB1440722A (en) * 1973-07-13 1976-06-23 Merck & Co Inc 2-1-piperazinyl-quinoxaline compounds having pharmaceutical activity
EP0008864A1 (en) * 1978-08-15 1980-03-19 FISONS plc Pyridopyrazine and quinoxaline derivatives, processes for their preparation, and pharmaceutical compositions containing them
CN1108935A (zh) * 1993-12-09 1995-09-27 赫彻斯特股份公司 含有喹喔啉和核苷的组合物制剂
CN1193968A (zh) * 1995-08-31 1998-09-23 诺瓦提斯公司 新的2,3－二氧－1,2,3,4－四氢－喹喔啉基衍生物

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DK716188D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Quinoxalinforbindelser, deres fremstilling og anvendelse
PT1534391E (pt) * 2002-07-19 2007-05-31 Biovitrum Ab Novos derivados e piperazinilo-pirazinona para o tratamento de desordens relacionadas com o receptor 5-ht

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3493572A (en) * 1968-07-05 1970-02-03 Pfizer & Co C Process for producing quinoxaline-di-n-oxides
GB1440722A (en) * 1973-07-13 1976-06-23 Merck & Co Inc 2-1-piperazinyl-quinoxaline compounds having pharmaceutical activity
EP0008864A1 (en) * 1978-08-15 1980-03-19 FISONS plc Pyridopyrazine and quinoxaline derivatives, processes for their preparation, and pharmaceutical compositions containing them
CN1108935A (zh) * 1993-12-09 1995-09-27 赫彻斯特股份公司 含有喹喔啉和核苷的组合物制剂
CN1193968A (zh) * 1995-08-31 1998-09-23 诺瓦提斯公司 新的2,3－二氧－1,2,3,4－四氢－喹喔啉基衍生物

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Lumma W. C. et al..Piperazinylquinoxalines with Central Serotoninmimetic Activity.J.Med.Chem.24.1981,2493-101. *
Lumma W.C.et al..Piperazinylquinoxalines with Central Serotoninmimetic Activity.J.Med.Chem.24.1981,2493-101. *

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US20050070527A1 (en) 2005-03-31
CN1886389A (zh) 2006-12-27
AU2004278372A1 (en) 2005-04-14
AU2010202009A1 (en) 2010-06-10
CA2540638A1 (en) 2005-04-14
AU2004278372B2 (en) 2010-02-18
EP1670774A1 (en) 2006-06-21
KR20060111466A (ko) 2006-10-27
WO2005033088A1 (en) 2005-04-14
ZA200603410B (en) 2007-07-25
MXPA06003578A (es) 2006-08-31
IL174629A0 (en) 2006-08-20
JP2007507514A (ja) 2007-03-29

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