CN1879821A - A method for preparing sugar-free granule with astragalus root, dendrobium stem and haw thorn fruit - Google Patents
A method for preparing sugar-free granule with astragalus root, dendrobium stem and haw thorn fruit Download PDFInfo
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- CN1879821A CN1879821A CN 200610051039 CN200610051039A CN1879821A CN 1879821 A CN1879821 A CN 1879821A CN 200610051039 CN200610051039 CN 200610051039 CN 200610051039 A CN200610051039 A CN 200610051039A CN 1879821 A CN1879821 A CN 1879821A
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Abstract
The invention discloses a process for making sugar-free granules comprising the following steps: disintegrating common yam rhizome 58.33 parts into fines, passing through 80-100 mesh sieve, ;watering and boiling three times, merging the grilling liquid, filtering and concentrating the filtrate into thick grease with specific gravity of 1.25-1.30 (60 deg C), charging common yam rhizome fines and starch gum 650-750 parts, and right amount of flavoring essence, mixing homogeneously, palletizing, granulating and drying.
Description
Technical field
The invention belongs to medical technical field, relate in particular to a kind of sugar-free granule with astragalus root, dendrobium stem and haw thorn fruit, preparation method.
Background technology
Anorexia, monophagia, hyperhidrosis that the spleen and stomach in children deficiency of vital energy, dysfunction of the spleen in transportation card cause, it is uncomfortable to defecate, symptoms such as easy catching a cold, stilbene dry measure used in former times short, bristly hair or beard electuary can improve patient's leukocyte inducement interferon ability and activate the phagocytic capacity, and stingy defence capability plays strengthening the spleen and nourishing the stomach, benefiting QI for strengthening the superficies, the dyspepsia and intestinal stasis relieving effect.Along with improving constantly of living standard, people's material life is more and more abundanter, owing to many reasons such as the unreasonable absorption of nutrient substance and overnutrition cause the onset diabetes rate more and more higher, and the trend that becomes younger in addition, children's's sickness rate also happens occasionally.And stilbene dry measure used in former times short, bristly hair or beard electuary, because its bitter in the mouth, the child is difficult for accepting, thereby is added with a large amount of sucrose, the one, increased the intake of child's sugar, and increased the risk that may suffer from diabetes undoubtedly; The 2nd, because making greatly, its cane sugar content is not easy to child administration by taking dose excessive (every bag contains sucrose 8.5g extractum and a small amount of adjuvant 1.5g, takes 10g at every turn), cost is also high.And in process of production, sucrose needs before use through being ground into fine powder, and this has not only increased operation, has increased production cost once more, and has increased the contaminated probability of medicine.
Summary of the invention
A kind of taking dose that under the situation that does not change medicine effective quantity, reduces that the objective of the invention is to overcome above-mentioned shortcoming and provide, simplified production process, reduce production cost, be beneficial to children taking, improved the preparation method of the sugar-free granule with astragalus root, dendrobium stem and haw thorn fruit of drug safety.
The selection of supplementary product kind of the present invention: test with starch, soluble starch, dextrin respectively, with the melting is to investigate index to show, starch and soluble starch are because water solublity is little, so the granule melting of making is undesirable, and because dextrin can be water-soluble, and have viscosity, can make granule with principal agent preferably, it is good to select for use dextrin to do the grain graininess that excipient the method according to this invention makes, and has overcome shortcomings such as caking when dry, piebaldism and pellet hardness be big.So select for use dextrin to make excipient.In addition aspartame, edible essence are made correctives, and mouthfeel is good, make that children's is more glad to take.
The selection of granulation condition: because aspartame, edible essence consumption are few, do not influence molding particles, so granule qualification rate and dextrin dosage, hydrojet speed, material temperature have direct relation, adopt three factors, three levels to make orthogonal test at this point, the results are shown in Table 1, table 2:
Table 1 granulation conditional filtering factor level table
| Level | Factor | ||
| A dextrin consumption (kg) | B hydrojet speed (Hz) | The C temperature of charge (℃) | |
| 1 2 3 | 10 20 30 | 20 25 30 | 35 40 45 |
Table 2 granulation conditional filtering orthogonal test table
| Row number | Factor | Granule yield (%) | ||
| A | B | C | ||
| 1 2 3 4 5 6 7 8 9 | 1 1 1 2 2 2 3 3 3 | 1 2 3 1 2 3 1 2 3 | 1 2 3 2 3 1 3 1 2 | 75.23 66.33 67.25 79.58 83.27 80.44 81.73 74.59 80.27 |
| I II III R | 208.81 243.29 236.59 11.49 | 236.54 224.19 227.96 4.12 | 230.26 226.18 232.25 2.02 | |
As seen from the above table, can observe directly A
2B
2C
3Yield is the highest, and test all is to feed intake for 100 times by the Example formulations amount, and after the conversion, dextrin: finished product=2: 3, the qualified granule of three batch samples is all more than 85%, and easy operating.
Obtain thus, the preparation method of sugar-free granule with astragalus root, dendrobium stem and haw thorn fruit of the present invention comprises the steps:
(1) take by weighing the raw material of following weight parts:
66.67 parts of 116.67 parts of Radix Glycyrrhizae Preparatas of 100 parts of Rhizoma dioscoreaes of the Radix Astragali
83.33 parts of 83.33 parts of Fructus Hordei Germinatus (parched)s of 100 parts of Herba Dendrobiis of Poria
93.33 parts of 83.33 parts of Radix Codonopsis of 106.67 portions of Fructus Chaenomeliss of Fructus Crataegi
100 parts of 66.67 parts of Rhizoma Atractylodis Macrocephalaes of Pericarpium Citri Reticulatae
(2) above ten simply, gets 58.33 parts of Rhizoma dioscoreaes, pulverize to be fine powder, sieve (80～100 order), fine powder is standby; All the other medical materials decoct with water three times, add 10 times of amounts of water for the first time, decoct 2 hours, second and third time adds 8 times of amounts of water respectively, decocts collecting decoction 1.5 hours, filter in (100 order), filtrate is concentrated into the clear paste that relative density is 1.25～1.30 (60 ℃), and adding Rhizoma dioscoreae fine powder, 650～750 parts in dextrin, aspartame and edible essence are an amount of, uniform mixing, granulate granulate, oven dry, make 1000 parts, promptly.
The present invention compared with prior art, dextrin is made excipient, aspartame, edible essence are made correctives, not only has the mouthfeel that good child takes like a shot, and do not change to reduce under the situation of medicine effective quantity and significantly reduce each taking dose (every bag contains dextrin 2g, and extractum 1g takes 3g at every turn, former dosage is 10g), dextrin can directly use, and has simplified production process, has reduced production cost, be beneficial to children taking, improved drug safety.
The specific embodiment
Embodiment 1
Take by weighing the raw material of following amount: Radix Astragali 100g, Rhizoma dioscoreae 116.67g, Radix Glycyrrhizae Preparata 66.67g, Poria 100g, Herba Dendrobii 83.33g, Fructus Hordei Germinatus (parched) 83.33g, Fructus Crataegi 106.67g, Fructus Chaenomelis 83.33g, Radix Codonopsis 93.33g, Pericarpium Citri Reticulatae 66.67g, Rhizoma Atractylodis Macrocephalae 100g.More than ten simply, get Rhizoma Dioscoreae 58.33g, pulverize and be fine powder, sieve (80～100 order), fine powder is standby; All the other medical materials decoct with water three times, add 10 times of amounts of water for the first time, decoct 2 hours, second and third time adds 8 times of amounts of water respectively, decocts collecting decoction 1.5 hours, filter in (100 order), filtrate is concentrated into the clear paste that relative density is 1.25～1.30 (60 ℃), and adding Rhizoma Dioscoreae fine powder, dextrin 650g, aspartame and edible essence are an amount of, uniform mixing, granulate granulate, oven dry, make 1000g, promptly.
Embodiment 2
Take by weighing the raw material of following amount: Radix Astragali 100g, Rhizoma dioscoreae 116.67g, Radix Glycyrrhizae Preparata 66.67g, Poria 100g, Herba Dendrobii 83.33g, Fructus Hordei Germinatus (parched) 83.33g, Fructus Crataegi 106.67g, Fructus Chaenomelis 83.33g, Radix Codonopsis 93.33g, Pericarpium Citri Reticulatae 66.67g, Rhizoma Atractylodis Macrocephalae 100g.More than ten simply, get Rhizoma Dioscoreae 58.33g, pulverize and be fine powder, sieve (80～100 order), fine powder is standby; All the other medical materials decoct with water three times, add 10 times of amounts of water for the first time, decoct 2 hours, second and third time adds 8 times of amounts of water respectively, decocts collecting decoction 1.5 hours, filter in (100 order), filtrate is concentrated into the clear paste that relative density is 1.25～1.30 (60 ℃), and adding Rhizoma Dioscoreae fine powder, dextrin 700g, aspartame and edible essence are an amount of, uniform mixing, granulate granulate, oven dry, make 1000g, promptly.
Embodiment 3
Take by weighing the raw material of following amount: Radix Astragali 100g, Rhizoma dioscoreae 116.67g, Radix Glycyrrhizae Preparata 66.67g, Poria 100g, Herba Dendrobii 83.33g, Fructus Hordei Germinatus (parched) 83.33g, Fructus Crataegi 106.67g, Fructus Chaenomelis 83.33g, Radix Codonopsis 93.33g, Pericarpium Citri Reticulatae 66.67g, Rhizoma Atractylodis Macrocephalae 100g.More than ten simply, get Rhizoma Dioscoreae 58.33g, pulverize and be fine powder, sieve (80～100 order), fine powder is standby; All the other medical materials decoct with water three times, add 10 times of amounts of water for the first time, decoct 2 hours, second and third time adds 8 times of amounts of water respectively, decocts collecting decoction 1.5 hours, filter in (100 order), filtrate is concentrated into the clear paste that relative density is 1.25～1.30 (60 ℃), and adding Rhizoma Dioscoreae fine powder, dextrin 750g, aspartame and edible essence are an amount of, uniform mixing, granulate granulate, oven dry, make 1000g, promptly.
Claims (1)
1, a kind of preparation method of sugar-free granule with astragalus root, dendrobium stem and haw thorn fruit comprises the steps:
(1) take by weighing the raw material of following weight parts:
66.67 parts of 116.67 parts of Radix Glycyrrhizae Preparatas of 100 parts of Rhizoma dioscoreaes of the Radix Astragali
83.33 parts of 83.33 parts of Fructus Hordei Germinatus (parched)s of 100 parts of Herba Dendrobiis of Poria
93.33 parts of 83.33 parts of Radix Codonopsis of 106.67 portions of Fructus Chaenomeliss of Fructus Crataegi
100 parts of 66.67 parts of Rhizoma Atractylodis Macrocephalaes of Pericarpium Citri Reticulatae
(2) above ten simply, gets 58.33 parts of Rhizoma dioscoreaes, pulverize to be fine powder, and 80～100 orders that sieve, fine powder is standby; All the other medical materials decoct with water three times, add 10 times of amounts of water for the first time, decoct 2 hours, second and third time adds 8 times of amounts of water respectively, decocts collecting decoction 1.5 hours, filtered 100 orders, filtrate is concentrated into 60 ℃, and to survey relative densities be 1.25～1.30 clear paste, and it is an amount of to add Rhizoma dioscoreae fine powder, 650～750 parts in dextrin, aspartame and edible essence, uniform mixing, granulate granulate, oven dry, make 1000 parts, promptly.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101905014A (en) * | 2010-08-03 | 2010-12-08 | 中国农业科学院上海兽医研究所 | Traditional Chinese medicine compound composition for treating diarrhea of weaned piglets |
| CN103689153A (en) * | 2013-12-12 | 2014-04-02 | 翟致远 | Spleen tonifying tea |
| CN110812455A (en) * | 2019-11-01 | 2020-02-21 | 葵花药业集团北京药物研究院有限公司 | A liquid oral preparation for treating children anorexia and monophagia, and its preparation method and application |
| WO2022040772A1 (en) * | 2020-08-25 | 2022-03-03 | Wenmin Du | Instant traditional-chinese-medicine dried powder for decoction and method of preparing and using same |
| CN115845005A (en) * | 2022-12-09 | 2023-03-28 | 葵花药业集团（贵州）宏奇有限公司 | Application of traditional Chinese medicine composition in adjusting expression level of PKA (protein kinase A) pathway-related protein of jejunum and preparing medicine |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1167457C (en) * | 2002-11-28 | 2004-09-22 | 贵州宏奇药业有限公司 | Traditional Chinese medicine granule contg. Radix Astragalus seu Hedysari, Herba Dendrobii, Frutus Crataegi, and its prepn. process |
-
2006
- 2006-04-29 CN CNB2006100510391A patent/CN100444879C/en active Active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101905014A (en) * | 2010-08-03 | 2010-12-08 | 中国农业科学院上海兽医研究所 | Traditional Chinese medicine compound composition for treating diarrhea of weaned piglets |
| CN103689153A (en) * | 2013-12-12 | 2014-04-02 | 翟致远 | Spleen tonifying tea |
| CN103689153B (en) * | 2013-12-12 | 2014-12-31 | 翟致远 | Spleen tonifying tea |
| CN110812455A (en) * | 2019-11-01 | 2020-02-21 | 葵花药业集团北京药物研究院有限公司 | A liquid oral preparation for treating children anorexia and monophagia, and its preparation method and application |
| WO2022040772A1 (en) * | 2020-08-25 | 2022-03-03 | Wenmin Du | Instant traditional-chinese-medicine dried powder for decoction and method of preparing and using same |
| CN115845005A (en) * | 2022-12-09 | 2023-03-28 | 葵花药业集团（贵州）宏奇有限公司 | Application of traditional Chinese medicine composition in adjusting expression level of PKA (protein kinase A) pathway-related protein of jejunum and preparing medicine |
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| CN100444879C (en) | 2008-12-24 |
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Address after: 553400 Guizhou city of Liupanshui province Liuzhi Mu Gang Industrial Park B District No. 6 Patentee after: Sunflower Pharmaceutical Group (Guizhou) macro wonder Co., Ltd. Address before: 550001 No. 4 Yong Feng Road, Guizhou, Guiyang Patentee before: Hongqi Pharmaceutical Co., Ltd., Guizhou |
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