CN104435258A - Codonopsis pilosula and radix astragali stomach invigorating granules and preparation method thereof - Google Patents
Codonopsis pilosula and radix astragali stomach invigorating granules and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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Abstract
The invention discloses codonopsis pilosula and radix astragali stomach invigorating granules, which comprise the following active ingredients: codonopsis pilosula, Chinese angelica, fructus crataegi, radix astragali, poria, radix glycyrrhizae, large-head atractylodes rhizome, ramulus cinnamomi, pericarpium citri reticulatae, caulis perilla, radix paeoniaealba, cuttlebone, radix inulae, and dandelion. The invention further provides a preparation method of the codonopsis pilosula and radix astragali stomach invigorating granules. The preparation method comprises the following steps: preparation of clear paste, expansion drying, high-pressure granulation, infrared granule screening, total blending, subpackaging and packaging to obtain codonopsis pilosula and radix astragali stomach invigorating granules. The blacking is removed by adopting expansion drying, the product and hot air are contacted to immediately remove the majority of moisture, solid substances in the materials are dried into powder, the particle size distribution and moisture content of the product can be controlled by utilizing the infrared granule screening, and the biological activity, solubility, color, aroma, and taste quality indexes can be effectively improved; through high-pressure granulation, the usage amount of auxiliary materials can be greatly decreased, and the rough, large and black phenomena of the traditional Chinese medicine can be overcome.
Description
Technical field
The invention belongs to medicine manufacture field, be specifically related to a kind of ginseng and astragalus stomach strengthening granules and preparation method thereof.
Background technology
Along with the quickening of modern's rhythm of life and the development of various fast service restaurant industry, the dietary habit of people often changes, and makes the sickness rate of gastropathy, and the sickness rate of especially between twenty and fifty gastropathy rises year by year.If gastropathy is treated not in time will be converted into old gastropathy, very easily carcinogenic.
Now ginseng and astragalus stomach strengthening granules commercially adopts the preparation method of conventional granulates agent to be prepared usually, one defect easily producing " thick black ", another is convenient, conventional method of granulating needs to add multiple auxiliary materials and carrys out auxiliary granulation, impurity component is many, make product active constituent content low, curative effect is undesirable simultaneously.
Summary of the invention
Goal of the invention: for solving problems of the prior art, the invention provides a kind of even particle size distribution, low, the eutherapeutic ginseng and astragalus stomach strengthening granules of impurity content and preparation method thereof.
Technical scheme: for realizing above-mentioned technical purpose, ginseng and astragalus stomach strengthening granules of the present invention is prepared from by the component of following parts by weight:
Radix Codonopsis 8 ~ 9 parts, the Radix Astragali 8 ~ 9 parts, the Rhizoma Atractylodis Macrocephalae 8 ~ 9 parts, Caulis Perillae 5 ~ 6 parts, Radix Inulae 4 ~ 5 parts, Radix Angelicae Sinensis 8 ~ 9 parts, 8 ~ 9 parts, Poria, Ramulus Cinnamomi 5 ~ 6 parts, the Radix Paeoniae Alba 8 ~ 9 parts, Herba Taraxaci 10 ~ 11 parts, Fructus Crataegi 8 ~ 9 parts, 4 ~ 5 parts, Radix Glycyrrhizae, Pericarpium Citri Reticulatae 5 ~ 6 parts, Endoconcha Sepiae 2 ~ 3 parts.
Present invention further proposes the preparation method of above-mentioned ginseng and astragalus stomach strengthening granules, comprise the steps:
(1) Radix Codonopsis of formula ratio, Radix Angelicae Sinensis, Fructus Crataegi, the Radix Astragali, Poria, Radix Glycyrrhizae, the Rhizoma Atractylodis Macrocephalae, Ramulus Cinnamomi, Pericarpium Citri Reticulatae, Caulis Perillae, the Radix Paeoniae Alba, Endoconcha Sepiae, Radix Inulae, Herba Taraxaci are dropped into extraction pot and decoct with water, after filtering, filtrate adds settling tank, centrifuged supernatant after leaving standstill, centrifugal liquid is concentrated, obtains clear paste;
(2) clear paste that step (1) obtains is carried out expansion drying, obtain clear paste powder;
(3) dextrin of formula ratio is added in the clear paste powder obtained to step (2); abundant mixed grinding 0.5 ~ 1h makes soft material; send in granulator and carry out high pressure granulation; then infrared particle screen selecting is carried out after spray-dried; through screening, qualified granule always mixes, obtain after subpackage, packaging; add magnesium stearate and carry out granulate, by always mixed, tabletting, coating, subpackage obtain ginseng and astragalus stomach strengthening granules.
Wherein, step decocts 2 times in (1) altogether, adds the water of 3 ~ 5 times amount for the first time, decocts 3 ~ 4h, and second time adds the water of 3 ~ 4 times amount, decocts 3 ~ 4h, filters respectively, merges and obtains filtrate.
In step (2), the temperature of expansion drying is 120 ~ 150 DEG C.
Preferably, the pressure limit that high pressure is granulated is 100 ~ 200Mpa.
Preferably, the particle size range of infrared particle screen selecting is 20 ~ 50 orders.
Beneficial effect: compared with prior art, the present invention has following technique effect:
(1) the present invention adopts expansion drying de-black, hot air, instantaneously most of moisture is being removed, the solid matter in material is made to be dried to powder, infrared granule is utilized to check the mark, control particle size distribution, the moisture content of product, effectively can improve biological activity, dissolubility, color quality index;
(2) by high pressure compressed granulating, the consumption of adjuvant can be greatly reduced, overcome Chinese medicine " thick black ", infrared granule segmentation, meets granule technology standard, the energy cost of saving, simultaneously, can ensure that basic substance is not destroyed, remain middle the effective elements of the medicine to greatest extent, improve the curative effect of product.
(3) ginseng and astragalus stomach strengthening granules of the present invention is not containing sucrose, and the phenomenon of the gelatinizing therefore avoided, product color is good.
Accompanying drawing explanation
Fig. 1 is process flow diagram of the present invention.
Detailed description of the invention
Embodiment 1
A preparation method for ginseng and astragalus stomach strengthening granules, the recipe ingredient of employing is by weight: Radix Codonopsis 8 parts, the Radix Astragali 9 parts, the Rhizoma Atractylodis Macrocephalae 8 parts, Caulis Perillae 6 parts, Radix Inulae 4 parts, Radix Angelicae Sinensis 9 parts, 8 parts, Poria, Ramulus Cinnamomi 6 parts, the Radix Paeoniae Alba 8 parts, Herba Taraxaci 11 parts, Fructus Crataegi 8 parts, 5 parts, Radix Glycyrrhizae, Pericarpium Citri Reticulatae 5 parts, Endoconcha Sepiae 3 parts.
Specifically comprise the steps:
(1) Radix Codonopsis of formula ratio, Radix Angelicae Sinensis, Fructus Crataegi, the Radix Astragali, Poria, Radix Glycyrrhizae, the Rhizoma Atractylodis Macrocephalae, Ramulus Cinnamomi, Pericarpium Citri Reticulatae, Caulis Perillae, the Radix Paeoniae Alba, Endoconcha Sepiae, Radix Inulae, Herba Taraxaci are dropped into extraction pot and decoct with water, decoct 2 times altogether, add the water of 3 times amount for the first time, decoct 4h, second time adds the water of 4 times amount, decoct 3h, filter respectively, merge and obtain filtrate, add settling tank, centrifuged supernatant after leaving standstill, concentrates centrifugal liquid, obtains clear paste;
(2) clear paste that step (1) obtains is carried out expansion drying at 120 DEG C, obtain clear paste powder;
(3) dextrin of formula ratio is added in the clear paste powder obtained to step (2), abundant mixed grinding 1h makes soft material, send in granulator and carry out high pressure granulation under 200Mpa, then infrared particle screen selecting is carried out after spray-dried, screen 20 object granules, always mix through screening qualified granule, subpackage, obtain after packaging, add magnesium stearate and carry out granulate, by total mixed, tabletting, coating, subpackage obtains ginseng and astragalus stomach strengthening granules, total mixed, subpackage, each step of packaging passes through strict quality inspection, the finished product outbound finally obtained, whole technological process as shown in Figure 1.
Embodiment 2
A preparation method for ginseng and astragalus stomach strengthening granules, the recipe ingredient of employing is by weight: Radix Codonopsis 9 parts, the Radix Astragali 9 parts, the Rhizoma Atractylodis Macrocephalae 8 parts, Caulis Perillae 6 parts, Radix Inulae 4 parts, Radix Angelicae Sinensis 9 parts, 8 parts, Poria, Ramulus Cinnamomi 6 parts, the Radix Paeoniae Alba 8 parts, Herba Taraxaci 11 parts, Fructus Crataegi 8 parts, 5 parts, Radix Glycyrrhizae, Pericarpium Citri Reticulatae 5 parts, Endoconcha Sepiae 3 parts.
Specifically comprise the steps:
(1) Radix Codonopsis of formula ratio, Radix Angelicae Sinensis, Fructus Crataegi, the Radix Astragali, Poria, Radix Glycyrrhizae, the Rhizoma Atractylodis Macrocephalae, Ramulus Cinnamomi, Pericarpium Citri Reticulatae, Caulis Perillae, the Radix Paeoniae Alba, Endoconcha Sepiae, Radix Inulae, Herba Taraxaci are dropped into extraction pot and decoct with water, decoct 3 times altogether, add the water of 10 times amount for the first time, decoct 1.5h, second time adds the water of 10 times amount, decoct 1.2h, add the water of 8 times amount for the third time, decoct 1.5h, filter respectively, merge and obtain filtrate, add settling tank, centrifuged supernatant after leaving standstill, concentrates centrifugal liquid, obtains clear paste;
(2) clear paste that step (1) obtains is carried out expansion drying at 130 DEG C, obtain clear paste powder;
(3) dextrin of formula ratio is added in the clear paste powder obtained to step (2); abundant mixed grinding 1h makes soft material; send in granulator and carry out high pressure granulation under 180Mpa; then infrared particle screen selecting is carried out after spray-dried; screen 50 object granules; through screening, qualified granule always mixes, obtain after subpackage, packaging, adds magnesium stearate and carries out granulate, obtains ginseng and astragalus stomach strengthening granules by total mixed, tabletting, coating, subpackage.
Embodiment 3
A preparation method for ginseng and astragalus stomach strengthening granules, the recipe ingredient of employing is by weight: Radix Codonopsis 8.5 parts, the Radix Astragali 8.5 parts, the Rhizoma Atractylodis Macrocephalae 8.5 parts, Caulis Perillae 5.5 parts, Radix Inulae 4.5 parts, Radix Angelicae Sinensis 8.5 parts, 8.5 parts, Poria, Ramulus Cinnamomi 5.5 parts, the Radix Paeoniae Alba 8.5 parts, Herba Taraxaci 10.5 parts, Fructus Crataegi 8.5 parts, 4.5 parts, Radix Glycyrrhizae, Pericarpium Citri Reticulatae 5.5 parts, Endoconcha Sepiae 2.5 parts.
Specifically comprise the steps:
(1) Radix Codonopsis of formula ratio, Radix Angelicae Sinensis, Fructus Crataegi, the Radix Astragali, Poria, Radix Glycyrrhizae, the Rhizoma Atractylodis Macrocephalae, Ramulus Cinnamomi, Pericarpium Citri Reticulatae, Caulis Perillae, the Radix Paeoniae Alba, Endoconcha Sepiae, Radix Inulae, Herba Taraxaci are dropped into extraction pot and decoct with water, in decoct 2 times altogether, first time adds the water of 5 times amount, decocts 3h, second time adds the water of 4 times amount, decoct 4h, filter respectively, merge and obtain filtrate, add settling tank, centrifuged supernatant after leaving standstill, concentrates centrifugal liquid, obtains clear paste;
(2) clear paste that step (1) obtains is carried out expansion drying at 150 DEG C, obtain clear paste powder;
(3) dextrin of formula ratio is added in the clear paste powder obtained to step (2); abundant mixed grinding 1h makes soft material; send in granulator and carry out high pressure granulation under 150Mpa; then infrared particle screen selecting is carried out after spray-dried; screen 30 object granules; through screening, qualified granule always mixes, obtain after subpackage, packaging, adds magnesium stearate and carries out granulate, obtains ginseng and astragalus stomach strengthening granules by total mixed, tabletting, coating, subpackage.
Comparative example 1:
A kind of ginseng and astragalus stomach strengthening granules, its recipe ingredient with embodiment 3, unlike, the drying in step (2) adopts conventional spraying dry, without particle screen selecting step in step (3).
Evaluating drug effect:
Observe the outward appearance of 4 groups of medicines, can find, drug particles prepared by embodiment 1 ~ 3 is comparatively regular, even particle size distribution, and color and luster is mellow and full, and without " thick black " phenomenon, and grain shape prepared by comparative example 1 is irregular, and color and luster is dark.
Respectively curative effect test is carried out to ginseng and astragalus stomach strengthening granules prepared by embodiment 1 ~ 3 and comparative example 1, random selecting suffers from the patient 2000 of stomachache, be divided into 5 groups, take the pleasant carbocisteine of above-described embodiment 1 ~ 3 and comparative example 1 preparation respectively, transfer index to well with symptom, result shows, embodiment cure rate is 97%, embodiment 2 is 96%, and embodiment is 98%, and comparative example 1 is 89%.
Result shows, by adopting expansion drying de-black, make product hot air, instantaneously most of moisture is being removed, the solid matter in material is made to be dried to powder, utilize infrared granule to check the mark, control particle size distribution, the moisture content of product, effectively can improve biological activity, dissolubility, color quality index; By high pressure compressed granulating, the consumption of adjuvant can be greatly reduced, overcome Chinese medicine " thick black ", infrared granule segmentation, meets granule technology standard, the energy cost of saving, simultaneously, can ensure that basic substance is not destroyed, remain middle the effective elements of the medicine to greatest extent, improve the curative effect of product.Meanwhile, because ginseng and astragalus stomach strengthening granules of the present invention is not containing sucrose, the phenomenon of the gelatinizing therefore avoided, product color is good.
Claims (6)
1. a ginseng and astragalus stomach strengthening granules, is characterized in that, it is prepared from by the component of following parts by weight:
Radix Codonopsis 8 ~ 9 parts, the Radix Astragali 8 ~ 9 parts, the Rhizoma Atractylodis Macrocephalae 8 ~ 9 parts, Caulis Perillae 5 ~ 6 parts, Radix Inulae 4 ~ 5 parts, Radix Angelicae Sinensis 8 ~ 9 parts, 8 ~ 9 parts, Poria, Ramulus Cinnamomi 5 ~ 6 parts, the Radix Paeoniae Alba 8 ~ 9 parts, Herba Taraxaci 10 ~ 11 parts, Fructus Crataegi 8 ~ 9 parts, 4 ~ 5 parts, Radix Glycyrrhizae, Pericarpium Citri Reticulatae 5 ~ 6 parts, Endoconcha Sepiae 2 ~ 3 parts.
2. the preparation method of ginseng and astragalus stomach strengthening granules according to claim 1, is characterized in that, comprises the steps:
(1) Radix Codonopsis of formula ratio, Radix Angelicae Sinensis, Fructus Crataegi, the Radix Astragali, Poria, Radix Glycyrrhizae, the Rhizoma Atractylodis Macrocephalae, Ramulus Cinnamomi, Pericarpium Citri Reticulatae, Caulis Perillae, the Radix Paeoniae Alba, Endoconcha Sepiae, Radix Inulae, Herba Taraxaci are dropped into extraction pot and decoct with water, after filtering, filtrate adds settling tank, centrifuged supernatant after leaving standstill, centrifugal liquid is concentrated, obtains clear paste;
(2) clear paste that step (1) obtains is carried out expansion drying, obtain clear paste powder;
(3) dextrin of formula ratio is added in the clear paste powder obtained to step (2); abundant mixed grinding 0.5 ~ 1h makes soft material; send in granulator and carry out high pressure granulation; then carry out infrared particle screen selecting after spray-dried, qualified granule always mixes through screening, obtain ginseng and astragalus stomach strengthening granules after subpackage, packaging.
3. the preparation method of ginseng and astragalus stomach strengthening granules according to claim 2, is characterized in that, step (1) decocts 2 times, add the water of 3 ~ 5 times amount for the first time, decoct 3 ~ 4h, second time adds the water of 3 ~ 4 times amount, decoct 3 ~ 4h to filter respectively, merge and obtain filtrate.
4. the preparation method of ginseng and astragalus stomach strengthening granules according to claim 2, is characterized in that, in step (2), the temperature of expansion drying is 120 ~ 150 DEG C.
5. the preparation method of ginseng and astragalus stomach strengthening granules according to claim 2, is characterized in that, the pressure limit that high pressure is granulated is 100 ~ 200Mpa.
6. the preparation method of ginseng and astragalus stomach strengthening granules according to claim 2, is characterized in that, the particle size range of infrared particle screen selecting is 14 ~ 16 orders.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105561131A (en) * | 2016-01-19 | 2016-05-11 | 苏州富欧生物科技有限公司 | Stomach warming and strengthening traditional Chinese medicine preparation |
| CN114247166A (en) * | 2021-12-27 | 2022-03-29 | 江苏帕特斯环保科技有限公司 | Horizontal spray flash evaporation granulating device and process thereof |
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- 2014-12-12 CN CN201410763715.2A patent/CN104435258A/en active Pending
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| Title |
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| 中华人民共和国卫生部药典委员会: "《中华人民共和国卫生部药品标准 中药成方制剂 第十册》", 31 December 1995 * |
| 赵新先: "《中药现代化》", 30 September 2002, 广东世界图书出版公司 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105561131A (en) * | 2016-01-19 | 2016-05-11 | 苏州富欧生物科技有限公司 | Stomach warming and strengthening traditional Chinese medicine preparation |
| CN114247166A (en) * | 2021-12-27 | 2022-03-29 | 江苏帕特斯环保科技有限公司 | Horizontal spray flash evaporation granulating device and process thereof |
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