CN104523781B - A kind of white sauce cold granules preparation method - Google Patents
A kind of white sauce cold granules preparation method Download PDFInfo
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- CN104523781B CN104523781B CN201510011462.8A CN201510011462A CN104523781B CN 104523781 B CN104523781 B CN 104523781B CN 201510011462 A CN201510011462 A CN 201510011462A CN 104523781 B CN104523781 B CN 104523781B
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- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 235000015067 sauces Nutrition 0.000 title claims abstract description 17
- 239000008187 granular material Substances 0.000 title claims abstract description 12
- 239000006071 cream Substances 0.000 claims abstract description 55
- 238000000605 extraction Methods 0.000 claims abstract description 32
- 240000008488 Thlaspi arvense Species 0.000 claims abstract description 19
- 235000008214 Thlaspi arvense Nutrition 0.000 claims abstract description 19
- 238000002156 mixing Methods 0.000 claims abstract description 19
- 239000007788 liquid Substances 0.000 claims abstract description 18
- 239000002245 particle Substances 0.000 claims abstract description 17
- 229920001353 Dextrin Polymers 0.000 claims abstract description 16
- 239000004375 Dextrin Substances 0.000 claims abstract description 16
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 16
- 229930006000 Sucrose Natural products 0.000 claims abstract description 16
- 235000019425 dextrin Nutrition 0.000 claims abstract description 16
- 239000005720 sucrose Substances 0.000 claims abstract description 16
- 238000010438 heat treatment Methods 0.000 claims abstract description 13
- 238000010992 reflux Methods 0.000 claims abstract description 13
- 238000001816 cooling Methods 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 206010013786 Dry skin Diseases 0.000 claims abstract description 8
- 238000001035 drying Methods 0.000 claims abstract description 8
- 238000000703 high-speed centrifugation Methods 0.000 claims abstract description 6
- 238000000034 method Methods 0.000 description 40
- 239000000463 material Substances 0.000 description 16
- 238000005119 centrifugation Methods 0.000 description 11
- 238000002844 melting Methods 0.000 description 6
- 230000008018 melting Effects 0.000 description 6
- 238000001914 filtration Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 239000011122 softwood Substances 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 241001419717 Anisodus luridus Species 0.000 description 2
- 244000148137 Patrinia villosa Species 0.000 description 2
- 235000019109 Patrinia villosa Nutrition 0.000 description 2
- 230000006837 decompression Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000008236 heating water Substances 0.000 description 2
- 150000002596 lactones Chemical class 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010028748 Nasal obstruction Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 210000005182 tip of the tongue Anatomy 0.000 description 1
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- Seeds, Soups, And Other Foods (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a kind of white sauce cold granules preparation method, comprise the following steps：White sauce extraction：The 1500g of field pennycress 1400,10~20 times are added to measure water refluxing extraction 2~5 hours, decoction is concentrated under reduced pressure into relative density 1.02~1.05 (70 DEG C of surveys), cooling, high speed centrifugation, extracting centrifugal liquid are concentrated under reduced pressure into the thick paste of relative density 1.25~1.35 (50 DEG C of surveys), receive cream, 200 mesh filter clothes are crossed, it is standby to receive cream.Particle preparation：353~1414g of sucrose, 88~353g of dextrin are taken, dry-mixed 5~10 points of kinds, the clear cream added after heating, wet mixing 10~15 minutes, particle is made, dries, 1000g is made；Or 44~176g of sucrose is added, 132~528g of dextrin, dry-mixed 5~10 points of kinds, the clear cream added after heating, wet mixing 10~15 minutes, particle is made, 60 DEG C~80 DEG C dryings, 470g is made, produces.
Description
Technical field：
The present invention relates to a kind of preparation method for the white sauce cold granules for treating anemopyretic cold.
Background technology
Anemopyretic cold is caused by evil criminal's table, the lung qi of wind-heat are become estranged.Symptoms are heating weight, micro- foul wind, distending pain in the head, are had
Sweat, red swelling and pain of throat, cough, phlegm are glutinous or yellow, the yellow tears of nasal obstruction, thirst and liking drink, the tip of the tongue side are red, the thin white micro- Huang of tongue.
White sauce cold granules are used for anemopyretic cold, pharyngalgia of generating heat, have the effect of good.
White sauce cold granules are the particles made of Patrinia villosa Juss medicinal material adds appropriate amount of auxiliary materials, are concealed in state food medicine
Surveillance Authority's national drug standards (WS~10880 (ZD)~2002~2011Z), function is with curing mainly to be clearing heat and detoxicating, evacuation
Wind-heat, for anemopyretic cold, pharyngalgia of generating heat.Usage and dosage is taken after mixing it with water for boiling water, and once a bag, 3 times a day, children are cut down according to the circumstance.
White sauce cold granules prepared by prior art, the extraction rate of transform of scopolactone wherein in Patrinia villosa Juss medicinal material
It is not high, therefore, the present invention is on the basis of existing technology, preparation method is improved, improves the extraction transfer of scopolactone
Rate is advantageous to the performance of drug effect, Improving The Quality of Products.
It is a discovery of the invention that traditional decocting process easily makes medicinal material local temperature too high, it is impossible to which completion desorbs, be molten very well
Solution, diffusion.Extraction process is improved for this present invention, solves problems with：
1st, the problem of scopolactone extraction is insufficient, the rate of transform of medicinal material active ingredient is improved.Introduce circumfluence distillation
Technology.
2nd, the melting of high speed tubular type centrifugation technique process improving product is introduced
The content of the invention
Present invention aims at provide a kind of white sauce cold granules preparation method.The present invention seeks to pass through following technical side
What case was realized.
A kind of white sauce cold granules preparation method of the present invention, it is characterised in that comprise the following steps：
1st, white sauce extraction：Field pennycress 1470g, 10~20 times are added to measure water refluxing extraction 2~5 hours, decoction is concentrated under reduced pressure into
Relative density 1.02~1.05 (70 DEG C of surveys), cooling, high speed centrifugation, extracting centrifugal liquid is concentrated under reduced pressure into relative density 1.25~1.35
The thick paste of (50 DEG C of surveys), receives cream, crosses 200 mesh filter clothes, it is standby to receive cream.
2nd, particle preparation：353~1414g of sucrose, 88~353g of dextrin are taken, dry-mixed 5~10 points of kinds, is added clear after heating
Cream, wet mixing 10~15 minutes, is made particle, dries, 1000g is made；Or 44~176g of sucrose, 132~528g of dextrin are added, do
5~10 points of kinds are mixed, the clear cream added after heating, wet mixing 10~15 minutes, particle is made, 60 DEG C~80 DEG C dryings, 470g is made
(low-sugar type), is produced.
The method according to the invention, the extraction rate of transform of the scopolactone in its field pennycress medicinal extract are far above existing art,
The method of the present invention is obtained by screening, and screening process is as follows：
1st, decocting cooking method
Method one
Field pennycress 1470g, add 10 times of amount decoctings to boil 3 times, 1 hour every time, merge decoction, filtration；Filtrate stands overnight, and takes
The thick paste that supernatant is concentrated under reduced pressure into relative density 1.32 (50 DEG C of surveys) is stood, cream is received, crosses 200 mesh filter clothes, it is standby to receive cream.
Method two
Field pennycress 1470g, add 15 times of amount decoctings to boil 2 times, 2 hours every time, merge decoction, filtration；Filtrate decompression is concentrated into
Relative density 1.02 (70 DEG C of surveys), is cooled down, centrifugation, and extracting centrifugal liquid is concentrated under reduced pressure into the thick paste of relative density 1.25 (50 DEG C of surveys),
Cream is received, crosses 200 mesh filter clothes, it is standby to receive cream.
Method three
Field pennycress 1470g, add 15 times of amount decoctings to boil 3 times, 1.5 hours every time, merge decoction, filtration；Filtrate stands overnight,
Take and stand the thick paste that supernatant is concentrated under reduced pressure into relative density 1.28 (50 DEG C of surveys), receive cream, cross 200 mesh filter clothes, it is standby to receive cream.
Method four
Field pennycress 1470g, add 20 times of amount decoctings to boil 2 times, 1 hour every time, merge decoction, filtration；Filtrate decompression is concentrated into
Relative density 1.05 (70 DEG C of surveys), is cooled down, centrifugation, and extracting centrifugal liquid is concentrated under reduced pressure into the thick paste of relative density 1.30 (50 DEG C of surveys),
Cream is received, crosses 200 mesh filter clothes, it is standby to receive cream.
The clear cream for taking method one to be prepared to method four, according to scopolactone content, it is as follows to calculate the field pennycress rate of transform：
| Method classification | Rate of transform % (in terms of Anisodus luridus lactone content) | Clear cream melting |
| Method one | 15.2% | It is unqualified |
| Method two | 16.8% | It is qualified |
| Method three | 17.9% | It is unqualified |
| Method four | 13.7% | It is qualified |
To sum up, it is universal relatively low according to the standard technology decocting method rate of transform between 14%~18%；By standard technology, decoct
Being stood overnight after liquid filtering, cream is received in concentration, and the melting of clear cream is unqualified, and after increase centrifugation, the melting of clear cream is improved,
The clear cream of extraction is disposably qualified.
Water bath reflux method
Method one
Field pennycress 44.1kg, 10 times are added to measure hydro-thermal refluxing extraction 4 hours, decoction is concentrated under reduced pressure into relative density 1.02 (70
DEG C survey), cooling, the centrifugation of high speed tubular type, extracting centrifugal liquid is concentrated under reduced pressure into the thick paste of relative density 1.28 (50 DEG C survey), receives cream, mistake
200 mesh filter clothes, it is standby to receive cream.
Method two
Field pennycress 44.1kg, 15 times are added to measure hydro-thermal refluxing extraction 3 hours, decoction is concentrated under reduced pressure into relative density 1.03 (70
DEG C survey), cooling, the centrifugation of high speed tubular type, extracting centrifugal liquid is concentrated under reduced pressure into the thick paste of relative density 1.35 (50 DEG C survey), receives cream, mistake
200 mesh filter clothes, it is standby to receive cream.
Method three
Field pennycress 44.1kg, 15 times are added to measure hydro-thermal refluxing extraction 2 hours, decoction is concentrated under reduced pressure into relative density 1.05 (70
DEG C survey), cooling, the centrifugation of high speed tubular type, extracting centrifugal liquid is concentrated under reduced pressure into the thick paste of relative density 1.30 (50 DEG C survey), receives cream, mistake
200 mesh filter clothes, it is standby to receive cream.
Method four
Field pennycress 44.1kg, 20 times are added to measure hydro-thermal refluxing extraction 3 hours, decoction is concentrated under reduced pressure into relative density 1.03 (70
DEG C survey), cooling, the centrifugation of high speed tubular type, extracting centrifugal liquid is concentrated under reduced pressure into the thick paste of relative density 1.32 (50 DEG C survey), receives cream, mistake
200 mesh filter clothes, it is standby to receive cream.
Method five
Field pennycress 44.1kg, 15 times are added to measure hydro-thermal refluxing extraction 5 hours, decoction is concentrated under reduced pressure into relative density 1.04 (70
DEG C survey), cooling, the centrifugation of high speed tubular type, extracting centrifugal liquid is concentrated under reduced pressure into the thick paste of relative density 1.25 (50 DEG C survey), receives cream, mistake
200 mesh filter clothes, it is standby to receive cream.
The clear cream for taking method one to be prepared to method five, according to scopolactone content, it is as follows to calculate the field pennycress rate of transform：
| Method classification | Rate of transform % (in terms of Anisodus luridus lactone content) | Clear cream melting |
| Method one | 37.4% | It is qualified |
| Method two | 40.5% | It is qualified |
| Method three | 38.3% | It is qualified |
| Method four | 42.7% | It is qualified |
| Method five | 43.5% | It is qualified |
To sum up, to be extracted using hot technique of backflow, the rate of transform is between 37%~44%, wherein the rate of transform of a method four is optimal,
The overall extraction rate of transform is about 2.5 times conventional of decocting method, and the extraction rate of transform of the method is higher, and extraction effect is good, and carries
Production efficiency is risen, shortens the production cycle.
Because the extracting method of medicinal extract is changed, therefore the preparation for granule is wanted it is also proposed that being correspondingly improved
Ask, screened for the preparation method of this dialogue sauce cold granules of the present invention：
1st, the preparation of clear cream：
Field pennycress 44.1kg, 20 times are added to measure hydro-thermal refluxing extraction 3 hours, decoction is concentrated under reduced pressure into relative density 1.03 (70
DEG C survey), cooling, the centrifugation of high speed tubular type, extracting centrifugal liquid is concentrated under reduced pressure into the thick paste of relative density 1.32 (50 DEG C survey), receives cream, mistake
200 mesh filter clothes, cream 3.969kg is received, it is standby.
2nd, particle preparation
2.1 specification：Per packed 17g
1. preparation process：
By above-mentioned 5 prescriptions, sucrose and dextrin are weighed respectively, are put in two-dimentional trough type mixing machine dry-mixed 5~10 minutes, are taken one
The clear cream (i.e. 132.3g) of individual recipe quantity, trough type mixing machine is slowly added into after heating water bath, 10~15min of wet mixing, softwood is made,
Put in oscillating granulator and pelletize, cross 18 mesh, wet granular is in 60 DEG C~80 DEG C dryings, and for control moisture below 2.0%, 18 mesh are whole
Reason, is produced.
2. interpretation of result：
The ratio of sucrose and dextrin is between 4~5, and obtained softwood is moderate, and chieftain is less with fine powder, obtained qualified
Grain is more, and prescription is preferable.
2.2 specification：Per packed 8g (low-sugar type)
1. preparation process：
By above-mentioned 5 prescriptions, sucrose and dextrin are weighed respectively, are put in two-dimentional trough type mixing machine dry-mixed 5~10 minutes, are taken one
The clear cream (i.e. 132.3g) of individual recipe quantity, trough type mixing machine is slowly added into after heating water bath, 10~15min of wet mixing, softwood is made,
Put in oscillating granulator and pelletize, cross 18 mesh, wet granular is in 60 DEG C~80 DEG C dryings, and for control moisture below 2.0%, 18 mesh are whole
Reason, is produced.
2. interpretation of result：
The ratio of dextrin and sucrose is between 3~5, and obtained softwood is moderate, and chieftain is less with fine powder, obtained qualified
Grain is more, and prescription is preferable.
The present invention uses hot technique of backflow, and Extraction solvent can constantly be desorbed with medicinal material, dissolve, spread, Jin Erda
To the effect fully extracted.The technology is that solvent is continuously fed on powder, and from top to bottom by medicinal material layer, the solute in medicinal material contains
Amount maintains higher gradient with solutes content in solvent, the solute high speed dissolution in medicinal material, until complete dissolution, has extraction effect
The characteristics of rate is high, extract solution stop being pumped into inspissator, and the indirect steam of concentration transfers cooler, and concentration continues, until dense
Shorten medicinal extract into, releasing is standby, and due to solute high speed dissolution, extraction time is short, and concentration is carried out simultaneously with extraction, and economic benefits and social benefits are taken in concentration
Concentration, the technology energy rapid concentration extract solution, effectively saves the energy.Therefore medicinal material is shorter than traditional time to concentration ointment, if
Standby utilization rate is high.The technical operation is to put into medicinal material in extractor, dosing material certain amount water, opens extractor and leads directly to and press from both sides
Steam valve is covered, after making medicinal material extract certain time, extract solution is pumped into inspissator and concentrated.The solvent of heat falls on the table of medicinal material
Face is extracted, and completes continuous an extraction and concentration.On the other hand, this product is prepared by standard technology, the melting of particle compared with
Difference, high speed tubular type centrifugation technique is introduced in this patent, and its separation principle sprays into rotary drum for the inlet of the bottom of material slave unit
It is interior, because rotary drum rotates at a high speed, force material in rotary drum, be layered because the proportion of each component is different, the liquid phase of clarification from turn
Drum top liquid outlet outflow；Solid phase stream squeezes into oral liquid in high speed tube centrifuge in rotary drum, carries out high-speed separation, reaches
To the purpose of separation of solid and liquid, so as to improve the quality of product.
Embodiment：
The present invention is further illustrated by the following examples, but not as limitation of the present invention.
Embodiment 1
1st, white sauce extraction：Field pennycress 1470g, 15 times are added to measure water refluxing extraction 3 hours, decoction is concentrated under reduced pressure into relative density
1.02~1.05 (70 DEG C of surveys), cooling, high speed centrifugation, extracting centrifugal liquid are concentrated under reduced pressure into relative density 1.25~1.35 (50 DEG C of surveys)
Thick paste, receive cream, cross 200 mesh filter clothes, receive cream it is standby.
2nd, particle preparation：Take sucrose 706g, dextrin 176g, dry-mixed 8 points of kinds, the clear cream added after heating, wet mixing 12 minutes,
Particle is made, dries, 1000g is made；
Or adding sucrose 88g, dextrin 264g, dry-mixed 8 points of kinds, the clear cream added after heating, wet mixing 12 minutes is made
Grain, 60 DEG C~80 DEG C dryings, is made 470g (low-sugar type), produces.
Embodiment 2
1st, white sauce extraction：Field pennycress 1470g, 10 times are added to measure water refluxing extraction 2 hours, decoction is concentrated under reduced pressure into relative density
1.02~1.05 (70 DEG C of surveys), cooling, high speed centrifugation, extracting centrifugal liquid are concentrated under reduced pressure into relative density 1.25~1.35 (50 DEG C of surveys)
Thick paste, receive cream, cross 200 mesh filter clothes, receive cream it is standby.
2nd, particle preparation：Take sucrose 353g, dextrin 88g, dry-mixed 5 points of kinds, the clear cream added after heating, wet mixing 10 minutes,
Particle is made, dries, 1000g is made；
Or adding sucrose 44g, dextrin 132g, dry-mixed 5 points of kinds, the clear cream added after heating, wet mixing 10 minutes is made
Grain, 60 DEG C of dryings, is made 470g (low-sugar type), produces.
Embodiment 3
1st, white sauce extraction：Field pennycress 1470g, 20 times are added to measure water refluxing extraction 5 hours, decoction is concentrated under reduced pressure into relative density
1.02~1.05 (70 DEG C of surveys), cooling, high speed centrifugation, extracting centrifugal liquid are concentrated under reduced pressure into relative density 1.25~1.35 (50 DEG C of surveys)
Thick paste, receive cream, cross 200 mesh filter clothes, receive cream it is standby.
2nd, particle preparation：Take sucrose 1414g, dextrin 353g, dry-mixed 10 points of kinds, the clear cream added after heating, wet mixing 15 divides
Clock, particle is made, dries, 1000g is made；
Or adding sucrose 176g, dextrin 528g, dry-mixed 10 points of kinds, the clear cream added after heating, wet mixing 15 minutes is made
Grain, 80 DEG C of dryings, is made 470g (low-sugar type), produces.
Claims (1)
1. a kind of white sauce cold granules preparation method, it is characterised in that comprise the following steps：
White sauce extraction：Field pennycress 1470g, 15 times are added to measure water refluxing extraction 3 hours, decoction is concentrated under reduced pressure into relative density at 70 DEG C
When survey be 1.02 ~ 1.05, cooling, high speed centrifugation, extracting centrifugal liquid be concentrated under reduced pressure into relative density is surveyed at 50 DEG C be 1.25 ~ 1.35
Thick paste, receive cream, cross 200 mesh filter clothes, receive cream it is standby；
Particle preparation：Take sucrose 706g, dextrin 176g, dry-mixed 8 minutes, the clear cream added after heating, wet mixing 12 minutes was made
Grain, dry, 1000g is made；
Or sucrose 88g, dextrin 264g are added, and dry-mixed 8 minutes, the clear cream added after heating, wet mixing 12 minutes was made particle, and 60
DEG C ~ 80 DEG C of dryings, 470g is made, produces.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102058637A (en) * | 2011-01-21 | 2011-05-18 | 云南云河药业有限公司 | Preparation method of patrimia scabiosaefolia extract |
| CN102579667A (en) * | 2011-12-21 | 2012-07-18 | 江西济民可信药业有限公司 | Preparation method of donkey-hide gelatin and Angelica blood-nourishing particles |
| CN103417589A (en) * | 2013-08-26 | 2013-12-04 | 重庆工商大学 | Preparation method and application of patrinia villosa root extractive |
-
2015
- 2015-01-10 CN CN201510011462.8A patent/CN104523781B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102058637A (en) * | 2011-01-21 | 2011-05-18 | 云南云河药业有限公司 | Preparation method of patrimia scabiosaefolia extract |
| CN102579667A (en) * | 2011-12-21 | 2012-07-18 | 江西济民可信药业有限公司 | Preparation method of donkey-hide gelatin and Angelica blood-nourishing particles |
| CN103417589A (en) * | 2013-08-26 | 2013-12-04 | 重庆工商大学 | Preparation method and application of patrinia villosa root extractive |
Non-Patent Citations (1)
| Title |
|---|
| 白酱感冒颗粒;国家药品监督管理局;《国家药品标准（试行）颁布件》;20021116;188页第2段 * |
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Denomination of invention: A preparation method of white sauce Ganmao granules Effective date of registration: 20211224 Granted publication date: 20180112 Pledgee: Bank of China Limited Nanchang Qingyunpu sub branch Pledgor: Jiangxi Jinshuibao Pharmaceutical Co.,Ltd. Registration number: Y2021980016165 |
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Denomination of invention: A kind of preparation method of Baijiang Ganmao Granules Effective date of registration: 20220905 Granted publication date: 20180112 Pledgee: Bank of China Limited Nanchang Qingyunpu sub branch Pledgor: Jiangxi Jinshuibao Pharmaceutical Co.,Ltd. Registration number: Y2022980014590 |
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Denomination of invention: A preparation method for white sauce cold granules Effective date of registration: 20230831 Granted publication date: 20180112 Pledgee: Bank of China Limited Nanchang Qingyunpu sub branch Pledgor: Jiangxi Jinshuibao Pharmaceutical Co.,Ltd. Registration number: Y2023980054963 |
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