CN103623165A - Preparation method of particles for treating infantile diarrhea - Google Patents
Preparation method of particles for treating infantile diarrhea Download PDFInfo
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- CN103623165A CN103623165A CN201310687202.3A CN201310687202A CN103623165A CN 103623165 A CN103623165 A CN 103623165A CN 201310687202 A CN201310687202 A CN 201310687202A CN 103623165 A CN103623165 A CN 103623165A
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Abstract
The invention relates to a preparation method of particles for treating infantile diarrhea. The preparation method comprises the following steps of: firstly preparing parched hawthorn fruit, fried atractylodes macrocephala, rhizoma pinelliae and prepared liquorice root; decocting parched hawthorn fruit, tuckahoe and costustoot twice and combining filtrates; concentrating to obtain a concentrated solution; standing for 24 hours, filtering and continuously concentrating to obtain a clear paste; adding ethanol to the extractum and uniformly stirring to obtain ethanol precipitation liquid; recycling ethanol and concentrating to obtain a thick paste I; preparing another clear paste from kudzuvine root, radix scutellariae, fried atractylodes macrocephala, magnolia officinalis, rhizoma pinelliae, rhizoma alismatis and prepared liquorice root; adding ethanol to obtain another ethanol precipitation liquid; recycling ethanol and concentrating to obtain a thick paste II; combining the thick paste I and the thick paste II; adding berberine tannate, stevioside and dextrin and uniformly mixing; adding ethanol to prepare a soft material; sieving and pelletizing; drying; granulating; drying; and spraying spice to obtain a medicament. The particles are prepared by using pure traditional Chinese medicines; the preparation method is simple and convenient; a medicament composition has less loss of active components content and high benefits, can be effectively used for treating infantile diarrhea, especially acute infantile diarrhea, chronic diarrhea, enteritidis, dysentery and the like, and is good in curative effect and quick in rehabilitation.
Description
Technical field
The present invention relates to a kind of preparation method for the treatment of infantile diarrhea granule.
Background technology
Infantile acute diarrhea, chronic diarrhea, enteritis and dysentery are the intestines and stomach diseases that children's often occurs.Existing treatment infantile diarrhea granule or be Western medicine, larger to taste infringement, or the Chinese patent medicine being prepared from for several tastes such as Poria, nutmeg, the Radix Aucklandiae, can not play the effect of heat-clearing and toxic substances removing and dampness removing and diarrhea-relieving.
Existing < < Chinese medicine > > (Chinese Patent Application No. 201110260578) who treats infantile diarrhea, is made by Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Poria, Herba Pogostemonis, the Radix Aucklandiae, Rhizoma Dioscoreae, Endothelium corneum, Radix Glycyrrhizae, Pericarpium Granati.CN101095932A discloses a kind of Chinese medicine of external application for treating children's lax, by Rhizoma Coptidis, Radix Bupleuri, Semen Myristicae, Semen Plantaginis, Galla Chinensis, the Radix Aucklandiae, Fructus Evodiae, Radix Sanguisorbae, Rhizoma Zingiberis, Borneolum Syntheticum, dry sustainability and grind into powder, cross 80～120 mesh sieves, the powder that mix homogeneously obtains.A < < Chinese medicinal granule for the treatment of infantile diarrhea and preparation method thereof > > (Chinese Patent Application No. 201210125548), by Flos Caryophylli, Poria, Fructus Schisandrae Chinensis, face roasted RADIX PUERARIAE, Fructus Evodiae, stir-baked SEMEN PLANTAGINIS with salt solution, Radix Scutellariae, Rhizoma Alismatis, Pericarpium Arecae, parching to brown Fructus Jujubae, Fructus Crataegi (parched to brown), Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Radix Aucklandiae (roasted), Fructus Mume, Herba Houttuyniae, Pericarpium Citri Reticulatae Viride, the Radix Astragali, Rhizoma Zingiberis Preparatum, parched with bran Endothelium Corneum Gigeriae Galli, Rhizoma Dioscoreae (parched with bran), Cortex Cinnamomi, charred Radix Sanguisorbae, Rhizoma Atractylodis Macrocephalae (parched), face Fructus Chebulae (roasted) passes through decocting, filter, concentrated, dry, granulate medicine.
Summary of the invention
The object of the invention is for above-mentioned present situation, aim to provide a kind of infringement of the taste to children's less, can play the preparation method of the treatment infantile diarrhea granule of heat-clearing and toxic substances removing and dampness removing and diarrhea-relieving effect simultaneously.
The implementation of the object of the invention is, a kind of preparation method for the treatment of infantile diarrhea granule, and concrete steps are:
1) by the material of respectively getting it filled of filling a prescription, remove respectively impurity, clean, according to prescription, require Fructus Crataegi, the Rhizoma Atractylodis Macrocephalae, the Rhizoma Pinelliae, Radix Glycyrrhizae to make Fructus Crataegi (parched to brown), Rhizoma Atractylodis Macrocephalae (parched), Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Radix Glycyrrhizae Preparata;
2) get 50～250g Fructus Crataegi (parched to brown), 55～320g Poria, 8～125g Radix Aucklandiae decoction secondary, filter merging filtrate; Decocting liquid after merging is concentrated into 55 ℃, the concentrated solution that relative density is 1.02; Standing 24 hours, filter; Continue to be concentrated into 85 ℃ of heat and survey, the clear paste that relative density is 1.20;
3) in the extractum making in step 1), add ethanol, making extractum contain alcohol amount is 40%, stirs, and standing 24 hours, filters to obtain alcohol deposit fluid; Reclaim ethanol, concentrated, 85 ℃ of heat of relative density are surveyed, and are 1.20 thick paste one;
4) 55～320g Radix Puerariae, 18～190g Radix Scutellariae, Rhizoma Atractylodis Macrocephalae (parched) 35～250g, 18～190 Cortex Magnoliae Officinalis, 18～190g Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), 35～190g Rhizoma Alismatis, 8～190g Radix Glycyrrhizae Preparata are prepared into clear paste by step 1), add ethanol, do not stop to stir, to extractum, containing alcohol amount is 55%, stir, standing 24 hours, filter to obtain alcohol deposit fluid; Reclaim ethanol, continue to concentrate, to 85 ℃ of heat surveys, the thick paste two that relative density is 1.20;
5) thick paste one, thick paste two are merged, add 5～10g berberine tannate and 1.0～5.5g stevioside, add 35～240g dextrin after mix homogeneously, mix homogeneously, adds appropriate ethanol to become soft material processed, the granulation of sieving;
6) step 4) gained granule is as for being dried under 60 ℃ of-80 ℃ of conditions, and continues, with 12 orders and 60 mesh sieve granulate, to be dried;
7) after granulate, the uniform particles of gained sprays into patchouli oil 0.3ml～1.6ml and assorted fruital essence 0.13ml-0.73ml, obtains medicine.
The present invention has the following advantages:
Granule children's of the present invention easily takes; Adopt pure Chinese medicine, can effectively cure infantile diarrhea, especially for infantile acute diarrhea, chronic diarrhea, enteritis and dysentery, curative effect of medication is good, and recovery time is fast; Can play heat-clearing and toxic substances removing, the effect of invigorating the spleen and regulating the stomach and dampness removing and diarrhea-relieving simultaneously.
During the present invention's extractum processed, adopt alcohol deposition method, compare the conventional prepared effective ingredient content loss of method by flooding less, income is high, and actual production is easy and simple to handle, can large scale investment produce.
The specific embodiment
It is ingredient that the present invention selects Fructus Crataegi (parched to brown), Poria, the Radix Aucklandiae, Radix Puerariae, Radix Scutellariae, Rhizoma Atractylodis Macrocephalae (parched), Cortex Magnoliae Officinalis, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Rhizoma Alismatis, Radix Glycyrrhizae Preparata, and scientific formulation is reasonable, and wherein Radix Puerariae can be delivered to dispel the heat by expelling pathogenic factors from muscles, again can hair growth promoting taste the gas of clear sun and antidiarrheal; Radix Scutellariae bitter cold, can heat clearing and damp drying, intestines strengthening and diarrhea checking, and berberine tannate is the effective ingredient in Rhizoma Coptidis, its cold in nature can clearing stomach intestinal heat, bitter in the mouth is can dry the intestines and stomach wet; Rhizoma Alismatis diuretic antidiarrheal; The medicine energy strengthening the spleen and stomaches such as the Rhizoma Atractylodis Macrocephalae, Poria, the Radix Aucklandiae, Cortex Magnoliae Officinalis, the Rhizoma Pinelliae, Fructus Crataegi, Rhizoma Alismatis, Herba Pogostemonis, reason the intestines and stomach, dampness removing heresy, aid digestion; And Radix Glycyrrhizae energy coordinating the actions of various ingredients in a prescription.Prescription Chinese medicine composition cooperatively interacts, and more can effectively cure infantile diarrhea, and especially for infantile acute diarrhea, chronic diarrhea, enteritis and dysentery, curative effect of medication is good, and recovery time is fast; Can play heat-clearing and toxic substances removing, the effect of invigorating the spleen and regulating the stomach and dampness removing and diarrhea-relieving simultaneously.
The present invention first makes Fructus Crataegi (parched to brown), Rhizoma Atractylodis Macrocephalae (parched), Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Radix Glycyrrhizae Preparata by Fructus Crataegi, the Rhizoma Atractylodis Macrocephalae, the Rhizoma Pinelliae, Radix Glycyrrhizae; 50～250g Fructus Crataegi (parched to brown), 55～320g Poria, 8～125g Radix Aucklandiae are decocted to secondary, merging filtrate; Concentrate to obtain concentrated solution; Standing 24 hours, filter, continue to concentrate to obtain clear paste; Extractum adds ethanol, and alcohol deposit fluid stirs to obtain; Reclaim ethanol concentrated that thick paste one, 55～320g Radix Puerariae, 18～190g Radix Scutellariae, 35～250g Rhizoma Atractylodis Macrocephalae (parched), 18～190 Cortex Magnoliae Officinalis, 18～190g Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), 35～190g Rhizoma Alismatis, 8～190g Radix Glycyrrhizae Preparata are made clear paste, add ethanol and obtain alcohol deposit fluid; Reclaim ethanol, concentrate to obtain thick paste two; Thick paste one, thick paste two merge, and add 5～10g berberine tannate and 1.0～5.5g stevioside, add dextrin, and mix homogeneously adds ethanol and becomes soft material processed, and the granulation of sieving is dry, granulate, and dry, fragrant material, obtains medicine.
Preferably, get 76～200g Fructus Crataegi (parched to brown), 70～285g Poria, 15～105g Radix Aucklandiae decoction secondary, 95～280g Radix Puerariae, 30～120g Radix Scutellariae, 50～200g Rhizoma Atractylodis Macrocephalae (parched), 30～165g Cortex Magnoliae Officinalis, 40～170g Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), 45～170g Rhizoma Alismatis, 50～156g Radix Glycyrrhizae Preparata are prepared into clear paste; Thick paste one, thick paste two are merged, add 6～9g berberine tannate.
Preferably, get 90～185g Fructus Crataegi (parched to brown), 100～250g Poria, 30～85g Radix Aucklandiae decoction secondary, 120～200g Radix Puerariae, 36～100g Radix Scutellariae, 65～180g Rhizoma Atractylodis Macrocephalae (parched), 45～140g Cortex Magnoliae Officinalis, 55～135g Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), 65～155g Rhizoma Alismatis, 75～140g Radix Glycyrrhizae Preparata are prepared into clear paste; Thick paste one, thick paste two are merged, add 7～8g berberine tannate.
Zoopery has been done to the medicine that adopts the present invention to prepare in institute for drug control, Wuhan City, zoopery shows: adopt medicine prepared by the present invention can obviously resist the diarrhea of mouse due to Oleum Ricini, and have an obvious inhibitory action to the mice intestinal due to neostigmine is hyperfunction.Think that this medicine is under child's usual amounts, safe house toxic and side effects.Hospital's infant such as Hubei Province healthcare hospital for women & children are to adopting medicine prepared by the present invention to pass through clinical trial, and Clinical results shows, medicine is better to infantile diarrhea curative effect, without obvious toxic-side effects.In addition, the heat-clearing and toxic substances removing of its prescription, drying damp and strengthening spleen, the functions such as stagnant stomach function regulating, promoting the circulation of QI to relieve pain that disappear and modern medicine are very identical to rule for the treatment of such as the infection of infantile diarrhea, aid digestion, regulating intestinal canal flora, convergence, fluid infusion.
With specific embodiment in detail the present invention is described in detail below.
Example 1,
1) by the material of respectively getting it filled of filling a prescription, remove respectively impurity, clean, according to prescription, require Fructus Crataegi, the Rhizoma Atractylodis Macrocephalae, the Rhizoma Pinelliae, Radix Glycyrrhizae to make Fructus Crataegi (parched to brown), Rhizoma Atractylodis Macrocephalae (parched), Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Radix Glycyrrhizae Preparata;
2) get 50g Fructus Crataegi (parched to brown), 55g Poria, 8g Radix Aucklandiae decoction secondary, filter merging filtrate; Decocting liquid after merging is concentrated into 55 ℃, the concentrated solution that relative density is 1.02; Standing 24 hours, filter; Continue to be concentrated into 85 ℃ of heat and survey, the clear paste that relative density is 1.20;
3) in the extractum making in step 1), add appropriate ethanol, making extractum contain alcohol amount is 40%, stirs, and standing 24 hours, filters to obtain alcohol deposit fluid; Reclaim ethanol, concentrated, 85 ℃ of heat of relative density are surveyed, and are 1.20 thick paste one;
4) 55g Radix Puerariae, 18g Radix Scutellariae, 35g Rhizoma Atractylodis Macrocephalae (parched), 18g Cortex Magnoliae Officinalis, 18g Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), 35g Rhizoma Alismatis, 8g Radix Glycyrrhizae Preparata are prepared into clear paste by step 1), add ethanol, do not stop to stir, to extractum, containing alcohol amount is 55%, stir, standing 24 hours, filter to obtain alcohol deposit fluid; Reclaim ethanol, continue to concentrate, to 85 ℃ of heat surveys, the thick paste two that relative density is 1.20;
5) thick paste one, thick paste two are merged, add 5g berberine tannate and 1.0g stevioside, add 35g dextrin after mix homogeneously, mix homogeneously, adds appropriate ethanol to become soft material processed, the granulation of sieving;
6) step 4) gained granule is as for being dried under 60 ℃ of-80 ℃ of conditions, and continues, with 12 orders and 60 mesh sieve granulate, to be dried;
7) after granulate, the uniform particles of gained sprays into 0.3ml patchouli oil and the assorted fruital essence of 0.13ml, obtains medicine.
Example 2 is with example 1, different:
2) get 250g Fructus Crataegi (parched to brown), 320g Poria, 125g Radix Aucklandiae decoction secondary, filter merging filtrate;
4) 320g Radix Puerariae, 190g Radix Scutellariae, 250g Rhizoma Atractylodis Macrocephalae (parched), 190g Cortex Magnoliae Officinalis, 190g Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), 190g Rhizoma Alismatis, 190g Radix Glycyrrhizae Preparata are prepared into clear paste by step 1), continue to be concentrated into relative density and be 1.20 thick paste two;
5) thick paste one, thick paste two are merged, add 10g berberine tannate and 5.5g stevioside, add 240g dextrin after mix homogeneously, mix homogeneously, adds appropriate ethanol to become soft material processed, the granulation of sieving;
6) step 4) gained granule is as for being dried under 80 ℃ of conditions, and continues, with 12 orders and 60 mesh sieve granulate, to be dried;
7) after granulate, the uniform particles of gained sprays into 1.6ml patchouli oil and the assorted fruital essence of 0.73ml, obtains medicine.
Example 3 is with example 1, different:
2) get 100g Fructus Crataegi (parched to brown), 110g Poria, 30g Radix Aucklandiae decoction secondary, filter merging filtrate;
4) 120g Radix Puerariae, 90g Radix Scutellariae, 110g Rhizoma Atractylodis Macrocephalae (parched), 80g Cortex Magnoliae Officinalis, 110g Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), 100g Rhizoma Alismatis, 80g Radix Glycyrrhizae Preparata are prepared into clear paste by step 1), continue to be concentrated into relative density and be 1.20 thick paste two;
5) thick paste one, thick paste two are merged, add 8g berberine tannate and 2.0g stevioside, add 120g dextrin after mix homogeneously, mix homogeneously, adds appropriate ethanol to become soft material processed, the granulation of sieving;
6) step 4) gained granule is as for being dried under 60 ℃ of conditions, and continues, with 12 orders and 60 mesh sieve granulate, to be dried;
7) after granulate, the uniform particles of gained sprays into 1.0ml patchouli oil and the assorted fruital essence of 0.25ml, obtains medicine.
Example 4 is with example 1, different:
2) get 185g Fructus Crataegi (parched to brown), 260g Poria, 85g Radix Aucklandiae decoction secondary, filter merging filtrate;
4) 280g Radix Puerariae, 140g Radix Scutellariae, 180g Rhizoma Atractylodis Macrocephalae (parched), 150g Cortex Magnoliae Officinalis, 160g Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), 120g Rhizoma Alismatis, 170g Radix Glycyrrhizae Preparata are prepared into clear paste by step 1), continue to be concentrated into relative density and be 1.20 thick paste two;
5) thick paste one, thick paste two are merged, add 7g berberine tannate and 3.0g stevioside, add 120g dextrin after mix homogeneously, mix homogeneously, adds appropriate ethanol to become soft material processed, the granulation of sieving;
6) step 4) gained granule is as for being dried under 70 ℃ of conditions, and continues, with 12 orders and 60 mesh sieve granulate, to be dried;
7) after granulate, the uniform particles of gained sprays into 0.8ml patchouli oil and the assorted fruital essence of 0.55ml, obtains pharmaceutical composition.
Example 5 is with example 1, different:
2) get 150g Fructus Crataegi (parched to brown), 70g Poria, 65g Radix Aucklandiae decoction secondary, filter merging filtrate;
4) 180g Radix Puerariae, 100g Radix Scutellariae, 180g Rhizoma Atractylodis Macrocephalae (parched), 140g Cortex Magnoliae Officinalis, 135g Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), 155g Rhizoma Alismatis, 156g Radix Glycyrrhizae Preparata are prepared into clear paste by step 1), continue to be concentrated into relative density and be 1.20 thick paste two;
5) thick paste one, thick paste two are merged, add 9g berberine tannate and 3.0g stevioside, add 120g dextrin after mix homogeneously, mix homogeneously, adds appropriate ethanol to become soft material processed, the granulation of sieving;
6) step 4) gained granule is as for being dried under 60 ℃ of-80 ℃ of conditions, and continues, with 12 orders and 60 mesh sieve granulate, to be dried;
7) after granulate, the uniform particles of gained sprays into 0.6ml patchouli oil and the assorted fruital essence of 0.35ml, obtains pharmaceutical composition.
Example 6 is with example 1, different:
2) get 90g Fructus Crataegi (parched to brown), 285g Poria, 105g Radix Aucklandiae decoction secondary, filter merging filtrate;
4) 220g Radix Puerariae, 75g Radix Scutellariae, 65g Rhizoma Atractylodis Macrocephalae (parched), 45g Cortex Magnoliae Officinalis, 90g Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), 170g Rhizoma Alismatis, 125g Radix Glycyrrhizae Preparata are prepared into clear paste by step 1), continue to be concentrated into relative density and be 1.20 thick paste two;
5) thick paste one, thick paste two are merged, add 6g berberine tannate and 3.0g stevioside, add 120g dextrin after mix homogeneously, mix homogeneously, adds appropriate ethanol to become soft material processed, the granulation of sieving;
6) step 4) gained granule is as for being dried under 60 ℃ of-80 ℃ of conditions, and continues, with 12 orders and 60 mesh sieve granulate, to be dried;
7) after granulate, the uniform particles of gained sprays into 0.6ml patchouli oil and the assorted fruital essence of 0.70ml, obtains pharmaceutical composition.
Example 7 is with example 1, different:
2) get 76g Fructus Crataegi (parched to brown), 100g Poria, 15g Radix Aucklandiae decoction secondary, filter merging filtrate;
4) 200g Radix Puerariae, 30g Radix Scutellariae, 200g Rhizoma Atractylodis Macrocephalae (parched), 165g Cortex Magnoliae Officinalis, 40g Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), 65g Rhizoma Alismatis, 75g Radix Glycyrrhizae Preparata are prepared into clear paste by step 1), continue to be concentrated into relative density and be 1.20 thick paste two;
5) thick paste one, thick paste two are merged, add 8g berberine tannate and 3.0g stevioside, add 120g dextrin after mix homogeneously, mix homogeneously, adds appropriate ethanol to become soft material processed, the granulation of sieving;
6) step 4) gained granule is as for being dried under 60 ℃ of-80 ℃ of conditions, and continues, with 12 orders and 60 mesh sieve granulate, to be dried;
7) after granulate, the uniform particles of gained sprays into 0.8ml patchouli oil and the assorted fruital essence of 0.68ml, obtains pharmaceutical composition.
Example 8 is with example 1, different:
2) get 200g Fructus Crataegi (parched to brown), 250g Poria, 120g Radix Aucklandiae decoction secondary, filter merging filtrate;
4) 95g Radix Puerariae, 120g Radix Scutellariae, 50g Rhizoma Atractylodis Macrocephalae (parched), 30g Cortex Magnoliae Officinalis, 170g Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), 45g Rhizoma Alismatis, 140g Radix Glycyrrhizae Preparata are prepared into clear paste by step 1), continue to be concentrated into relative density and be 1.20 thick paste two;
5) thick paste one, thick paste two are merged, add 7g berberine tannate and 3.0g stevioside, add 120g dextrin after mix homogeneously, mix homogeneously, adds appropriate ethanol to become soft material processed, the granulation of sieving;
6) step 4) gained granule is as for being dried under 60 ℃ of-80 ℃ of conditions, and continues, with 12 orders and 60 mesh sieve granulate, to be dried;
7) after granulate, the uniform particles of gained sprays into 1.2ml patchouli oil and the assorted fruital essence of 0.50ml, obtains pharmaceutical composition.
Example 9 is with example 1, different:
2) get 225g Fructus Crataegi (parched to brown), 180g Poria, 95g Radix Aucklandiae decoction secondary, filter merging filtrate;
4) 150g Radix Puerariae, 36g Radix Scutellariae, 150g Rhizoma Atractylodis Macrocephalae (parched), 65g Cortex Magnoliae Officinalis, 55g Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), 170g Rhizoma Alismatis, 50g Radix Glycyrrhizae Preparata are prepared into clear paste by step 1), continue to be concentrated into relative density and be 1.20 thick paste two;
5) thick paste one, thick paste two are merged, add 10g berberine tannate and 4.0g stevioside, add 120g dextrin after mix homogeneously, mix homogeneously, adds appropriate ethanol to become soft material processed, the granulation of sieving;
6) step 4) gained granule is as for being dried under 60 ℃ of-80 ℃ of conditions, and continues, with 12 orders and 60 mesh sieve granulate, to be dried;
7) after granulate, the uniform particles of gained sprays into 0.3ml patchouli oil and the assorted fruital essence of 0.30ml, obtains pharmaceutical composition.
Medicine of the present invention, except energy granulation shape, also can be prepared into capsule shape or tablet shape.Adopt and prepare particulate composition by above-mentioned any embodiment, to suffering from infantile diarrhea, particularly after the child and children taking of acute diarrhea, chronic diarrhea, enteritis and dysentery, can effectively treat, good drug efficacy, recovery time is fast, can play heat-clearing and toxic substances removing, the effect of invigorating the spleen and regulating the stomach and dampness removing and diarrhea-relieving simultaneously.
Claims (3)
1. a preparation method for the treatment of infantile diarrhea granule, is characterized in that, concrete steps are:
1) by the material of respectively getting it filled of filling a prescription, remove respectively impurity, clean, according to prescription, require Fructus Crataegi, the Rhizoma Atractylodis Macrocephalae, the Rhizoma Pinelliae, Radix Glycyrrhizae to make Fructus Crataegi (parched to brown), Rhizoma Atractylodis Macrocephalae (parched), Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Radix Glycyrrhizae Preparata;
2) get 50～250g Fructus Crataegi (parched to brown), 55～320g Poria, 8～125g Radix Aucklandiae decoction secondary, filter merging filtrate; Decocting liquid after merging is concentrated into 55 ℃, the concentrated solution that relative density is 1.02; Standing 24 hours, filter; Continue to be concentrated into 85 ℃ of heat and survey, the clear paste that relative density is 1.20;
3) in the extractum making in step 1), add ethanol, making extractum contain alcohol amount is 40%, stirs, and standing 24 hours, filters to obtain alcohol deposit fluid; Reclaim ethanol, concentrated, 85 ℃ of heat of relative density are surveyed, and are 1.20 thick paste one;
4) 55～320g Radix Puerariae, 18～190g Radix Scutellariae, Rhizoma Atractylodis Macrocephalae (parched) 35～250g, 18～190 Cortex Magnoliae Officinalis, 18～190g Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), 35～190g Rhizoma Alismatis, 8～190g Radix Glycyrrhizae Preparata are prepared into clear paste by step 1), add ethanol, do not stop to stir, to extractum, containing alcohol amount is 55%, stir, standing 24 hours, filter to obtain alcohol deposit fluid; Reclaim ethanol, continue to concentrate, to 85 ℃ of heat surveys, the thick paste two that relative density is 1.20;
5) thick paste one, thick paste two are merged, add 5～10g berberine tannate and 1.0～5.5g stevioside, add 35～240g dextrin after mix homogeneously, mix homogeneously, adds appropriate ethanol to become soft material processed, the granulation of sieving;
6) step 4) gained granule is as for being dried under 60 ℃ of-80 ℃ of conditions, and continues, with 12 orders and 60 mesh sieve granulate, to be dried;
7) after granulate, the uniform particles of gained sprays into patchouli oil 0.3ml～1.6ml and assorted fruital essence 0.13ml-0.73ml, obtains medicine.
2. a kind of preparation method for the treatment of infantile diarrhea granule according to claim 1, it is characterized in that getting 76～200g Fructus Crataegi (parched to brown), 70～285g Poria, 15～105g Radix Aucklandiae decoction secondary, 95～280g Radix Puerariae, 30～120g Radix Scutellariae, Rhizoma Atractylodis Macrocephalae (parched) 50～200g, 30～165g Cortex Magnoliae Officinalis, 40～170g Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), 45～170g Rhizoma Alismatis, 50～156g Radix Glycyrrhizae Preparata are prepared into clear paste; Thick paste one, thick paste two are merged, add 6～9g berberine tannate.
3. a kind of preparation method for the treatment of infantile diarrhea granule according to claim 1, it is characterized in that getting 90～185g Fructus Crataegi (parched to brown), 100～250g Poria, 30～85g Radix Aucklandiae decoction secondary, 120～200g Radix Puerariae, 36～100g Radix Scutellariae, Rhizoma Atractylodis Macrocephalae (parched) 65～180g, 45～140g Cortex Magnoliae Officinalis, 55～135g Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), 65～155g Rhizoma Alismatis, 75～140g Radix Glycyrrhizae Preparata are prepared into clear paste; Thick paste one, thick paste two are merged, add 7～8g berberine tannate.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105031176A (en) * | 2015-08-25 | 2015-11-11 | 李红霞 | Traditional Chinese medicine for treating acute infantile diarrhea caused by wind cold and preparation method of traditional Chinese medicine |
| CN105287415A (en) * | 2015-11-19 | 2016-02-03 | 哈尔滨圣吉药业股份有限公司 | Dispersing tablet used for infant acute and chronic diarrhea and preparation method thereof |
| JP2020045338A (en) * | 2018-09-12 | 2020-03-26 | 大正製薬株式会社 | External composition |
| CN115969951A (en) * | 2022-12-28 | 2023-04-18 | 华农（肇庆）生物产业技术研究院有限公司 | Anti-diarrhea preparation for treating pets and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101628064A (en) * | 2009-08-25 | 2010-01-20 | 红桃开集团股份有限公司 | Medicament composition for treating infantile diarrhea |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101628064A (en) * | 2009-08-25 | 2010-01-20 | 红桃开集团股份有限公司 | Medicament composition for treating infantile diarrhea |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105031176A (en) * | 2015-08-25 | 2015-11-11 | 李红霞 | Traditional Chinese medicine for treating acute infantile diarrhea caused by wind cold and preparation method of traditional Chinese medicine |
| CN105287415A (en) * | 2015-11-19 | 2016-02-03 | 哈尔滨圣吉药业股份有限公司 | Dispersing tablet used for infant acute and chronic diarrhea and preparation method thereof |
| JP2020045338A (en) * | 2018-09-12 | 2020-03-26 | 大正製薬株式会社 | External composition |
| CN115969951A (en) * | 2022-12-28 | 2023-04-18 | 华农（肇庆）生物产业技术研究院有限公司 | Anti-diarrhea preparation for treating pets and preparation method thereof |
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Application publication date: 20140312 |