CN1871350B - 用于引发肿瘤细胞致死的核酸 - Google Patents

用于引发肿瘤细胞致死的核酸 Download PDF

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Publication number
CN1871350B
CN1871350B CN200480031278.XA CN200480031278A CN1871350B CN 1871350 B CN1871350 B CN 1871350B CN 200480031278 A CN200480031278 A CN 200480031278A CN 1871350 B CN1871350 B CN 1871350B
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dna
dril
dril32
cells
molecules
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Expired - Lifetime
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CN200480031278.XA
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English (en)
Chinese (zh)
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CN1871350A (zh
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马里·迪特雷
孙建生
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France National Medical Association Of Health And Research
State Museum Of Natural History
Centre National de la Recherche Scientifique CNRS
Institut Curie
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France National Medical Association Of Health And Research
State Museum Of Natural History
Centre National de la Recherche Scientifique CNRS
Institut Curie
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/13—Decoys
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
CN200480031278.XA 2003-10-24 2004-10-25 用于引发肿瘤细胞致死的核酸 Expired - Lifetime CN1871350B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03292666A EP1526177A1 (en) 2003-10-24 2003-10-24 Nucleic acids useful for triggering tumor cell lethality
EP03292666.9 2003-10-24
PCT/EP2004/012857 WO2005040378A1 (en) 2003-10-24 2004-10-25 Nucleic acids useful for triggering tumor cell lethality

Publications (2)

Publication Number Publication Date
CN1871350A CN1871350A (zh) 2006-11-29
CN1871350B true CN1871350B (zh) 2014-10-15

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CN200480031278.XA Expired - Lifetime CN1871350B (zh) 2003-10-24 2004-10-25 用于引发肿瘤细胞致死的核酸

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Country Link
US (1) US7595302B2 (https=)
EP (2) EP1526177A1 (https=)
JP (2) JP4743789B2 (https=)
CN (1) CN1871350B (https=)
AT (1) ATE485375T1 (https=)
AU (1) AU2004284228B2 (https=)
CA (1) CA2542942C (https=)
CY (1) CY1111060T1 (https=)
DE (1) DE602004029699D1 (https=)
DK (1) DK1675954T3 (https=)
ES (1) ES2354359T3 (https=)
PL (1) PL1675954T3 (https=)
PT (1) PT1675954E (https=)
SI (1) SI1675954T1 (https=)
WO (1) WO2005040378A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108261548A (zh) * 2018-01-10 2018-07-10 浙江大学 一种纳米复合物及其制备方法和应用

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US7476729B2 (en) * 2003-10-24 2009-01-13 Institut Curie Dbait and uses thereof
EP1944369A1 (en) * 2007-01-12 2008-07-16 The Centre National de la Recherche Scientifique Dbait and its standalone uses thereof
WO2009149921A2 (en) * 2008-06-11 2009-12-17 Bionucleon S.R.L. Inhibition of hrp-3 using modified oligonucleotides
US9205099B2 (en) 2010-06-22 2015-12-08 Dna Therapeutics Optimized in vivo delivery system with endosomolytic agents for nucleic acid conjugates
AU2015202211B2 (en) * 2010-06-22 2016-09-01 Centre National De La Recherche Scientifique Optimized in vivo delivery system with endosomolytic agents for nucleic acid conjugates
EP2527440A1 (en) * 2011-05-27 2012-11-28 Institut Curie Cancer treatment by combining DNA molecules mimicking double strand breaks with hyperthermia
AU2014316676B2 (en) * 2013-09-04 2020-07-23 Csir Site-specific nuclease single-cell assay targeting gene regulatory elements to silence gene expression
EP3919621A1 (en) * 2014-06-23 2021-12-08 The General Hospital Corporation Genomewide unbiased identification of dsbs evaluated by sequencing (guide-seq)
JP6457696B2 (ja) 2015-07-23 2019-01-23 アンスティテュ・キュリＩｎｓｔｉｔｕｔ Ｃｕｒｉｅ 癌を処置するためのＤｂａｉｔ分子とＰＡＲＰインヒビターとの組合せの使用
US10821128B2 (en) * 2016-03-01 2020-11-03 Onxeo Treatment of cancer by systemic administration of Dbait molecules
WO2017186882A1 (en) 2016-04-29 2017-11-02 Onxeo A method of predicting a response to an anti-tumor treatment by means of signal interfering dna molecules
US10876116B2 (en) 2016-07-15 2020-12-29 The Board Of Regents Of The University Of Oklahoma Anti-ARID3a treatments for inflammatory disorders
WO2018162439A1 (en) 2017-03-08 2018-09-13 Onxeo New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule
EP3461488A1 (en) 2017-09-27 2019-04-03 Onxeo Combination of a dbait molecule and a hdac inhibitor for treating cancer
KR20200130856A (ko) 2018-03-13 2020-11-20 옹쎄오 암 치료에서 획득한 내성에 대한 디베이트 분자
CA3097044A1 (en) 2018-04-17 2019-10-24 The General Hospital Corporation Sensitive in vitro assays for substrate preferences and sites of nucleic acid binding, modifying, and cleaving agents
WO2020127965A1 (en) 2018-12-21 2020-06-25 Onxeo New conjugated nucleic acid molecules and their uses
US20220143049A1 (en) 2019-03-21 2022-05-12 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
TW202210633A (zh) 2020-06-05 2022-03-16 法商昂席歐公司 用於治療癌症之dbait分子與kras抑制劑的組合
AR122644A1 (es) 2020-06-19 2022-09-28 Onxeo Nuevas moléculas de ácido nucleico conjugado y sus usos
JP2025500922A (ja) 2021-12-16 2025-01-15 ヴァレリオ・セラピューティクス 新規のコンジュゲートされた核酸分子及びその使用
WO2024240858A1 (en) 2023-05-23 2024-11-28 Valerio Therapeutics Protac molecules directed against dna damage repair system and uses thereof

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NZ255028A (en) * 1992-07-02 1997-03-24 Hybridon Inc Antisense oligonucleotides resistant to nucleolytic degradation
US6441158B1 (en) * 1997-12-31 2002-08-27 Medical College Of Georgia Research Institute, Inc. Oligomers that bind to ku protein
EP0978561A1 (en) * 1998-08-07 2000-02-09 Hoechst Marion Roussel Deutschland GmbH Antisense oligonucleotides for the inhibition of VEGF expression
AU2002241952A1 (en) * 2001-01-22 2002-07-30 Genta Incorporated Cell-proliferative disorder treatments using cre decoy oligomers, bcl-2 antisense and hybrid oligomers
CA2476468A1 (en) 2002-02-13 2003-08-21 Medbridge, Inc. Protein carrier system for therapeutic oligonucleotides
AU2003207708A1 (en) 2002-02-20 2003-09-09 Sirna Therapeutics, Inc. Rna interference mediated inhibition of map kinase genes

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OMORI S, ET AL,.SUPPRESSION OF A DOUBLE-STRAND BREAK REPAIRGENE, KU70, INCREASES RADIO- ANDCHEMOSENSITIVITY IN A HUMAN LUNG CARCINOMACELL LINE.DNA, REPAIR, ELSEVIER.2002,299-310. *
江国春,等,.DNA依赖蛋白激酶研究进展.生物化学与生物物理进展26 6.1999,26(6),531-534. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108261548A (zh) * 2018-01-10 2018-07-10 浙江大学 一种纳米复合物及其制备方法和应用

Also Published As

Publication number Publication date
WO2005040378A1 (en) 2005-05-06
DK1675954T3 (da) 2011-01-10
EP1675954A1 (en) 2006-07-05
CY1111060T1 (el) 2015-06-11
AU2004284228B2 (en) 2010-04-08
PL1675954T3 (pl) 2011-04-29
JP4743789B2 (ja) 2011-08-10
SI1675954T1 (sl) 2011-01-31
ATE485375T1 (de) 2010-11-15
ES2354359T3 (es) 2011-03-14
CA2542942C (en) 2014-04-29
JP2007510405A (ja) 2007-04-26
US20070197458A1 (en) 2007-08-23
JP2011126897A (ja) 2011-06-30
PT1675954E (pt) 2010-12-27
EP1526177A1 (en) 2005-04-27
US7595302B2 (en) 2009-09-29
JP5662822B2 (ja) 2015-02-04
DE602004029699D1 (de) 2010-12-02
CN1871350A (zh) 2006-11-29
CA2542942A1 (en) 2005-05-06
AU2004284228A1 (en) 2005-05-06
EP1675954B1 (en) 2010-10-20

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Granted publication date: 20141015