CN1871350B - 用于引发肿瘤细胞致死的核酸 - Google Patents

用于引发肿瘤细胞致死的核酸 Download PDF

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Publication number
CN1871350B
CN1871350B CN200480031278.XA CN200480031278A CN1871350B CN 1871350 B CN1871350 B CN 1871350B CN 200480031278 A CN200480031278 A CN 200480031278A CN 1871350 B CN1871350 B CN 1871350B
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dna
dril
dril32
cells
molecules
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Expired - Lifetime
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CN200480031278.XA
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Chinese (zh)
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CN1871350A (zh
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马里·迪特雷
孙建生
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France National Medical Association Of Health And Research
State Museum Of Natural History
Centre National de la Recherche Scientifique CNRS
Institut Curie
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France National Medical Association Of Health And Research
State Museum Of Natural History
Centre National de la Recherche Scientifique CNRS
Institut Curie
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/13—Decoys
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
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  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
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  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
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  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
CN200480031278.XA 2003-10-24 2004-10-25 用于引发肿瘤细胞致死的核酸 Expired - Lifetime CN1871350B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03292666.9 2003-10-24
EP03292666A EP1526177A1 (en) 2003-10-24 2003-10-24 Nucleic acids useful for triggering tumor cell lethality
PCT/EP2004/012857 WO2005040378A1 (en) 2003-10-24 2004-10-25 Nucleic acids useful for triggering tumor cell lethality

Publications (2)

Publication Number Publication Date
CN1871350A CN1871350A (zh) 2006-11-29
CN1871350B true CN1871350B (zh) 2014-10-15

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CN200480031278.XA Expired - Lifetime CN1871350B (zh) 2003-10-24 2004-10-25 用于引发肿瘤细胞致死的核酸

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Country Link
US (1) US7595302B2 (https=)
EP (2) EP1526177A1 (https=)
JP (2) JP4743789B2 (https=)
CN (1) CN1871350B (https=)
AT (1) ATE485375T1 (https=)
AU (1) AU2004284228B2 (https=)
CA (1) CA2542942C (https=)
CY (1) CY1111060T1 (https=)
DE (1) DE602004029699D1 (https=)
DK (1) DK1675954T3 (https=)
ES (1) ES2354359T3 (https=)
PL (1) PL1675954T3 (https=)
PT (1) PT1675954E (https=)
SI (1) SI1675954T1 (https=)
WO (1) WO2005040378A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108261548A (zh) * 2018-01-10 2018-07-10 浙江大学 一种纳米复合物及其制备方法和应用

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US7476729B2 (en) * 2003-10-24 2009-01-13 Institut Curie Dbait and uses thereof
EP1944369A1 (en) * 2007-01-12 2008-07-16 The Centre National de la Recherche Scientifique Dbait and its standalone uses thereof
WO2009149921A2 (en) * 2008-06-11 2009-12-17 Bionucleon S.R.L. Inhibition of hrp-3 using modified oligonucleotides
AU2015202211B2 (en) * 2010-06-22 2016-09-01 Centre National De La Recherche Scientifique Optimized in vivo delivery system with endosomolytic agents for nucleic acid conjugates
JP5860874B2 (ja) 2010-06-22 2016-02-16 デエヌア・テラプーティックＤｎａｔｈｅｒａｐｅｕｔｉｃｓ 核酸コンジュゲートのためのエンドソーム溶解剤を用いた最適化ｉｎｖｉｖｏ送達システム
EP2527440A1 (en) * 2011-05-27 2012-11-28 Institut Curie Cancer treatment by combining DNA molecules mimicking double strand breaks with hyperthermia
EP3636750A1 (en) * 2013-09-04 2020-04-15 Csir Site-specific nuclease single-cell assay targeting gene regulatory elements to silence gene expression
CN106604994B (zh) * 2014-06-23 2021-12-14 通用医疗公司 通过测序评估的DSBs的全基因组无偏鉴定(GUIDE-Seq)
AU2016296905B2 (en) 2015-07-23 2018-07-05 Centre National De La Recherche Scientifique Use of a combination of Dbait molecule and parp inhibitors to treat cancer
KR102441432B1 (ko) * 2016-03-01 2022-09-07 옹쎄오 Ｄｂａｉｔ 분자의 전신 투여에 의한 암 치료법
WO2017186882A1 (en) 2016-04-29 2017-11-02 Onxeo A method of predicting a response to an anti-tumor treatment by means of signal interfering dna molecules
WO2018013912A1 (en) * 2016-07-15 2018-01-18 The Board Of Regents Of The University Of Oklahoma Anti-arid3a treatments for inflammatory disorders
WO2018162439A1 (en) 2017-03-08 2018-09-13 Onxeo New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule
EP3461488A1 (en) 2017-09-27 2019-04-03 Onxeo Combination of a dbait molecule and a hdac inhibitor for treating cancer
CA3092779A1 (en) 2018-03-13 2019-09-19 Onxeo A dbait molecule against acquired resistance in the treatment of cancer
US11898203B2 (en) 2018-04-17 2024-02-13 The General Hospital Corporation Highly sensitive in vitro assays to define substrate preferences and sites of nucleic-acid binding, modifying, and cleaving agents
BR112021012066A2 (pt) 2018-12-21 2021-11-03 Onxeo Novas moléculas de ácido nucleico conjugadas e seus usos
EA202192575A1 (ru) 2019-03-21 2022-01-14 Онксео Соединения dbait в сочетании с ингибиторами киназ для лечения рака
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
TW202210633A (zh) 2020-06-05 2022-03-16 法商昂席歐公司 用於治療癌症之dbait分子與kras抑制劑的組合
TW202214857A (zh) 2020-06-19 2022-04-16 法商昂席歐公司 新型結合核酸分子及其用途
KR20240133795A (ko) 2021-12-16 2024-09-04 발레리오 테라퓨틱스 신규한 컨쥬게이티드 핵산 분자 및 이의 용도
WO2024240858A1 (en) 2023-05-23 2024-11-28 Valerio Therapeutics Protac molecules directed against dna damage repair system and uses thereof

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江国春,等,.DNA依赖蛋白激酶研究进展.生物化学与生物物理进展26 6.1999,26(6),531-534. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108261548A (zh) * 2018-01-10 2018-07-10 浙江大学 一种纳米复合物及其制备方法和应用

Also Published As

Publication number Publication date
ATE485375T1 (de) 2010-11-15
US7595302B2 (en) 2009-09-29
JP2011126897A (ja) 2011-06-30
WO2005040378A1 (en) 2005-05-06
JP2007510405A (ja) 2007-04-26
CY1111060T1 (el) 2015-06-11
CN1871350A (zh) 2006-11-29
DE602004029699D1 (de) 2010-12-02
AU2004284228A1 (en) 2005-05-06
PL1675954T3 (pl) 2011-04-29
AU2004284228B2 (en) 2010-04-08
ES2354359T3 (es) 2011-03-14
EP1675954B1 (en) 2010-10-20
DK1675954T3 (da) 2011-01-10
JP4743789B2 (ja) 2011-08-10
PT1675954E (pt) 2010-12-27
CA2542942C (en) 2014-04-29
SI1675954T1 (sl) 2011-01-31
US20070197458A1 (en) 2007-08-23
CA2542942A1 (en) 2005-05-06
EP1675954A1 (en) 2006-07-05
JP5662822B2 (ja) 2015-02-04
EP1526177A1 (en) 2005-04-27

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