CN1871024B - 牙周病和牙髓疾病的治疗剂以及治疗方法 - Google Patents

牙周病和牙髓疾病的治疗剂以及治疗方法 Download PDF

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Publication number
CN1871024B
CN1871024B CN2004800311946A CN200480031194A CN1871024B CN 1871024 B CN1871024 B CN 1871024B CN 2004800311946 A CN2004800311946 A CN 2004800311946A CN 200480031194 A CN200480031194 A CN 200480031194A CN 1871024 B CN1871024 B CN 1871024B
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cells
bdnf
mrna expression
ngf
action time
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Chinese (zh)
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CN1871024A (zh
Inventor
栗原英见
河口浩之
武田克浩
柴秀树
水野智仁
吉野宏
长谷川直彦
筱原弘明
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Two Cells Co Ltd
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Two Cells Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Zoology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2004800311946A 2003-09-09 2004-09-08 牙周病和牙髓疾病的治疗剂以及治疗方法 Expired - Fee Related CN1871024B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP316719/2003 2003-09-09
JP2003316719 2003-09-09
PCT/JP2004/013023 WO2005025605A1 (ja) 2003-09-09 2004-09-08 歯周病と歯髄疾患の治療剤と治療方法

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN201210032026.5A Division CN102526706B (zh) 2003-09-09 2004-09-08 牙周病和牙髓疾病的治疗剂以及治疗方法
CN201210032750.8A Division CN102600455B (zh) 2003-09-09 2004-09-08 牙周病和牙髓疾病的治疗剂以及治疗方法

Publications (2)

Publication Number Publication Date
CN1871024A CN1871024A (zh) 2006-11-29
CN1871024B true CN1871024B (zh) 2012-03-28

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Family Applications (3)

Application Number Title Priority Date Filing Date
CN2004800311946A Expired - Fee Related CN1871024B (zh) 2003-09-09 2004-09-08 牙周病和牙髓疾病的治疗剂以及治疗方法
CN201210032750.8A Expired - Fee Related CN102600455B (zh) 2003-09-09 2004-09-08 牙周病和牙髓疾病的治疗剂以及治疗方法
CN201210032026.5A Expired - Fee Related CN102526706B (zh) 2003-09-09 2004-09-08 牙周病和牙髓疾病的治疗剂以及治疗方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN201210032750.8A Expired - Fee Related CN102600455B (zh) 2003-09-09 2004-09-08 牙周病和牙髓疾病的治疗剂以及治疗方法
CN201210032026.5A Expired - Fee Related CN102526706B (zh) 2003-09-09 2004-09-08 牙周病和牙髓疾病的治疗剂以及治疗方法

Country Status (8)

Country Link
US (3) US8158752B2 (https=)
EP (3) EP2460528B1 (https=)
JP (2) JP4589233B2 (https=)
CN (3) CN1871024B (https=)
AU (1) AU2004271843B2 (https=)
RU (1) RU2336089C2 (https=)
TW (1) TW200513264A (https=)
WO (1) WO2005025605A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8113837B2 (en) 2007-11-26 2012-02-14 Peter John Zegarelli Oral appliance for delivering a medicament
US8927284B2 (en) * 2009-01-28 2015-01-06 Organ Technologies, Inc. Method for producing tooth
US8470303B2 (en) * 2010-02-02 2013-06-25 James C. Richards Automated method and system for introducing molecular iodine into drinking water
RU2449760C1 (ru) * 2011-01-12 2012-05-10 Светлана Минифаритовна Алетдинова Способ лечения хронических верхушечных периодонтитов
US11273022B2 (en) 2018-02-13 2022-03-15 Emanate Biomedical, Inc. Oral appliance in a blockchain system
US20190247173A1 (en) 2018-02-13 2019-08-15 Peter John Zegarelli Methods of making an oral appliance
WO2019183201A1 (en) * 2018-03-20 2019-09-26 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Regeneration of vital tooth pulp
WO2019241577A1 (en) 2018-06-13 2019-12-19 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Bone regeneration in compromised wounds
CN112220966A (zh) * 2020-11-23 2021-01-15 北京大学口腔医学院 一种注射剂、注射剂的制备方法及其在牙髓再生中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229500A (en) * 1989-08-30 1993-07-20 Regeneron Pharmaceuticals, Inc. Brain derived neurotrophic factor
US5372503A (en) * 1993-04-27 1994-12-13 Dental Marketing Specialists, Inc. Method for installation of a dental implant
JPH09511666A (ja) * 1994-04-08 1997-11-25 アトリックス・ラボラトリーズ・インコーポレイテッド 医療装置で使用する付随的ポリマー系
AU723740B2 (en) * 1995-06-06 2000-09-07 Howmedica Inc. Biocompatible hydroxyapatite formulations and uses therefor
RU2096031C1 (ru) * 1996-09-19 1997-11-20 Акционерное общество "НИЗАР" Средство для профилактики и лечения воспалительных заболеваний тканей пародонта

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
TSUBOI Y. ET AL.Mitogenic effects of neurotrophins on a periodontalligamentcell line.JOURNAL OF DENTAL RESEARCH80 3.2001,80(3),881 - 886，具体参见摘要、第881页右栏最后一段以及第885页左栏第二段.
TSUBOI Y. ET AL.Mitogenic effects of neurotrophins on a periodontalligamentcell line.JOURNAL OF DENTAL RESEARCH80 3.2001,80(3),881- 886,具体参见摘要、第881页右栏最后一段以及第885页左栏第二段. *
刘军.神经生长因子和神经肽对牙乳头间充质细胞和牙胚生长、分化影响的体外实验研究.第四军医大学学位论文.1998,摘要. *
卜令学等.下牙槽神经挤压伤后再生的实验研究.现代口腔医学杂志16 1.2002,16(1),21-23，具体参见摘要.
卜令学等.下牙槽神经挤压伤后再生的实验研究.现代口腔医学杂志16 1.2002,16(1),21-23,具体参见摘要. *
董研等.TrkA及PPTA mRNA在咬合创伤犬三叉神经节内的表达变化.口腔颌面修复学杂志4 1.2003,4(1),4-7.
董研等.TrkA及PPTA mRNA在咬合创伤犬三叉神经节内的表达变化.口腔颌面修复学杂志4 1.2003,4(1),4-7. *

Also Published As

Publication number Publication date
US20120214738A1 (en) 2012-08-23
RU2006111465A (ru) 2007-10-27
EP2460528B1 (en) 2014-03-19
EP2460529A1 (en) 2012-06-06
CN102526706A (zh) 2012-07-04
TW200513264A (en) 2005-04-16
JPWO2005025605A1 (ja) 2007-11-08
US20070071693A1 (en) 2007-03-29
US9089606B2 (en) 2015-07-28
US8158752B2 (en) 2012-04-17
JP5313209B2 (ja) 2013-10-09
WO2005025605A1 (ja) 2005-03-24
EP2460528A1 (en) 2012-06-06
CN102600455B (zh) 2015-04-15
EP1671641B1 (en) 2013-11-06
AU2004271843A1 (en) 2005-03-24
EP1671641A1 (en) 2006-06-21
EP1671641A4 (en) 2009-08-19
JP4589233B2 (ja) 2010-12-01
EP2460529B1 (en) 2014-08-20
CN102526706B (zh) 2014-07-30
RU2336089C2 (ru) 2008-10-20
JP2010215661A (ja) 2010-09-30
US20120165255A1 (en) 2012-06-28
CN102600455A (zh) 2012-07-25
US8513191B2 (en) 2013-08-20
AU2004271843B2 (en) 2010-04-08
CN1871024A (zh) 2006-11-29

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