CN1867573A - 制备反式-或顺式-二铵二氯二羟合铂(ⅳ)的方法及其用于制备药物有效物质的用途 - Google Patents
制备反式-或顺式-二铵二氯二羟合铂(ⅳ)的方法及其用于制备药物有效物质的用途 Download PDFInfo
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- CN1867573A CN1867573A CNA2004800298890A CN200480029889A CN1867573A CN 1867573 A CN1867573 A CN 1867573A CN A2004800298890 A CNA2004800298890 A CN A2004800298890A CN 200480029889 A CN200480029889 A CN 200480029889A CN 1867573 A CN1867573 A CN 1867573A
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Description
细胞种类 | 顺式-铂 | 顺式-氧代铂 | 羰基铂 | 奥沙利铂 |
HOS骨肉瘤 | nd | 2.5 | 5 | nd |
SaOS骨肉瘤 | nd | 5 | 5 | nd |
PC3前列腺 | res | 7.5 | 10 | nd |
M607黑素瘤 | 0.3 | 5 | 10 | 10 |
M518黑素瘤 | 40 | res | res | res |
Me128黑素瘤 | 0.3 | 2.5 | 10 | 10 |
JVSO黑素瘤 | 40 | 10 | res | res |
Pancl胰腺癌 | 1 | 40 | 20 | 5 |
BxPC3胰腺癌 | 0.6 | 2.5 | 10 | 10 |
MiaPaCa2胰腺癌 | 1.5 | 5 | 5 | 5 |
HCT8结肠癌 | 5 | 40 | res | res |
HT29结肠癌 | 0.3 | 20 | 20 | 20 |
HCT-15结肠癌 | 0.3 | 20 | res | 10 |
A498肾细胞 | 1 | 20 | res | 10 |
C320DM结肠癌 | 0.3 | 2.5 | 10 | 0.15 |
Colo205结肠癌 | 10 | res | res | 1 |
CC1227结肠癌 | 0.3 | 10 | res | 0.2 |
MCF-7乳腺癌 | 2.5 | 5.5 | res | res |
T47D乳腺癌 | 0.3 | 2.5 | nd | 0.1 |
细胞种类 | IC50μg/ml | |
顺式-氧代铂 | 顺式-氧代铂钠盐 | |
T47D乳腺癌 | 3 | 18 |
SK-OV3卵巢癌 | 15 | 22 |
U 373MG星状细胞瘤 | 15 | 18 |
BxPC3胰腺癌 | 13 | 12 |
SK-OV4卵巢癌 | 16.2 | 12.8 |
PC3前列腺 | 7.5 | 5.3 |
CaCo-2结肠 | 1.52 | 2.22 |
CRO2B癌 | 3.0 | 10.1 |
HT29结肠 | 13.5 | 4.55 |
Du145前列腺 | 19.0 | 27.0 |
SW480结肠 | 8.2 | 2.5 |
SIM肉瘤 | 15.2 | 11.2 |
浓度(μg/ml) | %存活率/氧代铂 | %存活率/钠盐 |
4020105 | 15.8±2.756.0±6.387.4±11.8105.2±10.8 | 0.6±0.533.2±3.077.7±2.4109.3±9.1 |
细胞种类 | 氧代铂(IC50-μg/ml) |
EW-7(EFT)SIM(EFT)KAL(EFT)LAN1(NB)LAN5(NB) | 1.2514未测试173.5 |
细胞种类 | 来源 | 氧代铂IC50(μg/ml) | 氧代铂-CaIC50(μg/ml) |
SW480 | 结肠 | 8.2 | 2.5 |
MDA-MB-435 | 乳腺 | 16.5 | 12.0 |
BT20 | 乳腺 | 3.75 | 3.5 |
Colo205 | 结肠 | 29.0 | 13.5 |
Du145 | 前列腺 | 19.0 | 14.5 |
HT29 | 结肠 | 13.5 | 8.0 |
CRO2B | 良性肿瘤 | 3.0 | 2.20 |
CaCo-2 | 结肠 | 1.52 | 0.87 |
BxPC3 | 胰腺 | 26.0 | 30.0 |
T47D | 乳腺 | 2.5 | 3.6 |
细胞种类 | 在40μg/ml TRAXO下的存活率%(当显示20μm/ml时除外) |
U-87-MG星形细胞瘤 | 100 |
ASTRO星形细胞瘤 | 82(20)71 |
SW620结肠癌 | 43/51/97 |
MDA-MB-231乳腺癌 | 70/103/106 |
G-292骨肉瘤 | 8.6/68 |
PANCl胰腺癌 | 100 |
CRO1A类癌瘤 | 87/104/70 |
CRO2B类癌瘤 | 24/57 |
MIAPaCa2胰腺癌 | 92/83 |
Fib3成纤维细胞瘤 | 91 |
K562白血病 | 97 |
WI-38胚胎、肺成纤维细胞瘤 | 21 |
COLO205结肠癌 | 109 |
HCT-15结肠癌 | 100 |
T-47D乳腺癌 | 101 |
HL-60白血病 | 0.5 |
HOS骨肉瘤 | 4.3 |
ACHN肾癌 | 48 |
BxPC3胰腺癌 | 106 |
Claims (10)
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EP03090344A EP1524273B1 (de) | 2003-10-13 | 2003-10-13 | Verfahren zur Herstellung von trans- oder cis-Diammoniumdichlorodihydroxoplatin (IV)-Salzen und -Derivaten und ihre Verwendung zur Herstellung von pharmazeutischen Wirkstoffen |
EP03090344.7 | 2003-10-13 | ||
US60/512,097 | 2003-10-20 |
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CN1867573A true CN1867573A (zh) | 2006-11-22 |
CN100526324C CN100526324C (zh) | 2009-08-12 |
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US (1) | US7687651B2 (zh) |
EP (2) | EP1524273B1 (zh) |
JP (1) | JP4887153B2 (zh) |
CN (1) | CN100526324C (zh) |
AT (2) | ATE346076T1 (zh) |
AU (1) | AU2004283125B2 (zh) |
BR (1) | BRPI0415295A (zh) |
CA (1) | CA2565096C (zh) |
DE (3) | DE50305768D1 (zh) |
DK (1) | DK1678189T3 (zh) |
ES (1) | ES2284061T3 (zh) |
HK (1) | HK1097848A1 (zh) |
MX (1) | MXPA06003843A (zh) |
PL (1) | PL1678189T3 (zh) |
RU (1) | RU2345086C2 (zh) |
UA (1) | UA85066C2 (zh) |
WO (1) | WO2005040045A2 (zh) |
ZA (1) | ZA200603018B (zh) |
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CN103043635A (zh) * | 2012-12-25 | 2013-04-17 | 浙江大学 | 一种抗耐药性的顺铂矿化液及其制备方法和应用 |
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DK1523984T3 (da) * | 2003-10-13 | 2007-03-26 | Zoser B Salama | Farmaceutisk sammensætning indeholdende oxoplatin og dettes salte |
CZ2004964A3 (cs) * | 2004-09-14 | 2006-03-15 | Pliva-Lachema A. S. | Perorální farmaceutická kompozice pro cílený transport komplexu platiny do kolorektální oblasti, zpusob její prípravy a tato kompozice pro pouzití jako lécivo |
WO2009156706A1 (en) * | 2008-06-27 | 2009-12-30 | University Of Strathclyde | Pulmonary drug delivery with vesicles comprising non-ionic surfactants |
WO2014100417A1 (en) * | 2012-12-19 | 2014-06-26 | Blend Therapeutics, Inc. | Compounds, compositions, and methods for the treatment of cancers |
EP4311830A1 (en) * | 2022-07-29 | 2024-01-31 | King Faisal Specialist Hospital & Research Centre | Cisplatin analogue with potent anti-cancer effects and synthesis thereof |
WO2024023197A1 (en) * | 2022-07-29 | 2024-02-01 | King Faisal Specialist Hospital & Research Centre | Cisplatin analogue with potent anti-cancer and cancer stem cell-targeting effects and synthesis thereof |
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GB1585103A (en) * | 1976-04-06 | 1981-02-25 | Rustenburg Platinum Mines Ltd | Pharmaceutical compositions containing platinum compounds |
IL63658A0 (en) * | 1980-09-03 | 1981-11-30 | Johnson Matthey Plc | Co-ordination compound of platinum and its preparation |
SU1021116A1 (ru) | 1981-11-20 | 1996-11-20 | МГУ им. М.В.Ломоносова | Способ получения цис-диамминдихлородигидроксоплатины (iy) |
SU1137698A1 (ru) * | 1983-10-17 | 1996-09-27 | МГУ им. М.В.Ломоносова | Способ получения цис-диамминдихлородигидроксоплатины (iy) |
ATE113054T1 (de) * | 1988-02-02 | 1994-11-15 | Johnson Matthey Inc | Pt(iv) komplexe. |
US5196555A (en) * | 1989-10-17 | 1993-03-23 | Bristol-Myers Squibb Company | Water and solvent soluble axial hydroxy and mono- and di- carboxylic acid derivatives having high tumor activity |
RU2086261C1 (ru) * | 1994-07-08 | 1997-08-10 | Химический факультет Московского государственного университета им.М.В.Ломоносова | Противоопухолевое средство |
JPH10251285A (ja) * | 1997-03-14 | 1998-09-22 | Ss Pharmaceut Co Ltd | 白金(iv)錯体及びこれを含有する医薬 |
DK1523984T3 (da) | 2003-10-13 | 2007-03-26 | Zoser B Salama | Farmaceutisk sammensætning indeholdende oxoplatin og dettes salte |
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CN103043635A (zh) * | 2012-12-25 | 2013-04-17 | 浙江大学 | 一种抗耐药性的顺铂矿化液及其制备方法和应用 |
CN103043635B (zh) * | 2012-12-25 | 2015-04-22 | 浙江大学 | 一种抗耐药性的顺铂矿化液及其制备方法和应用 |
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Publication number | Publication date |
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US7687651B2 (en) | 2010-03-30 |
EP1524273B1 (de) | 2006-11-22 |
CA2565096A1 (en) | 2005-05-06 |
EP1678189B1 (de) | 2007-03-21 |
EP1524273A1 (de) | 2005-04-20 |
RU2345086C2 (ru) | 2009-01-27 |
US20070286905A1 (en) | 2007-12-13 |
MXPA06003843A (es) | 2007-02-02 |
AU2004283125B2 (en) | 2009-06-25 |
HK1097848A1 (en) | 2007-07-06 |
BRPI0415295A (pt) | 2006-12-26 |
ES2284061T3 (es) | 2007-11-01 |
CN100526324C (zh) | 2009-08-12 |
DE50305768D1 (de) | 2007-01-04 |
EP1678189A2 (de) | 2006-07-12 |
DK1678189T3 (da) | 2007-06-11 |
ZA200603018B (en) | 2007-07-25 |
WO2005040045A2 (de) | 2005-05-06 |
RU2006116314A (ru) | 2007-11-20 |
JP4887153B2 (ja) | 2012-02-29 |
CA2565096C (en) | 2011-02-22 |
AU2004283125A1 (en) | 2005-05-06 |
DE112004002485D2 (de) | 2006-08-24 |
ATE357451T1 (de) | 2007-04-15 |
ATE346076T1 (de) | 2006-12-15 |
DE502004003311D1 (de) | 2007-05-03 |
JP2007513066A (ja) | 2007-05-24 |
WO2005040045A3 (de) | 2005-07-07 |
UA85066C2 (ru) | 2008-12-25 |
PL1678189T3 (pl) | 2007-08-31 |
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