CN1856305B - 用作尾加压素ⅱ拮抗剂的吡啶衍生物 - Google Patents

用作尾加压素ⅱ拮抗剂的吡啶衍生物 Download PDF

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Publication number
CN1856305B
CN1856305B CN2004800277254A CN200480027725A CN1856305B CN 1856305 B CN1856305 B CN 1856305B CN 2004800277254 A CN2004800277254 A CN 2004800277254A CN 200480027725 A CN200480027725 A CN 200480027725A CN 1856305 B CN1856305 B CN 1856305B
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China
Prior art keywords
ethyl
pyridin
piperidin
dimethyl
urea groups
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Expired - Fee Related
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CN2004800277254A
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Chinese (zh)
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CN1856305A (zh
Inventor
博里斯·马蒂斯
克劳斯·米勒
米夏埃尔·舍茨
托马斯·韦勒
马丁内·克洛泽尔
约尔格·韦尔克
丹尼尔·比尔
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Actelion Pharmaceuticals Ltd
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Actelion Pharmaceuticals Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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  • Animal Behavior & Ethology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
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  • Physical Education & Sports Medicine (AREA)
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  • Obesity (AREA)
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  • Communicable Diseases (AREA)
  • Addiction (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
CN2004800277254A 2003-09-26 2004-09-21 用作尾加压素ⅱ拮抗剂的吡啶衍生物 Expired - Fee Related CN1856305B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EPPCT/EP03/10746 2003-09-26
EP0310746 2003-09-26
PCT/EP2004/010559 WO2005030209A1 (en) 2003-09-26 2004-09-21 Pyridine derivatives and use thereof as urotensin ii antagonists

Publications (2)

Publication Number Publication Date
CN1856305A CN1856305A (zh) 2006-11-01
CN1856305B true CN1856305B (zh) 2010-04-28

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CN2004800277254A Expired - Fee Related CN1856305B (zh) 2003-09-26 2004-09-21 用作尾加压素ⅱ拮抗剂的吡啶衍生物

Country Status (18)

Country Link
US (1) US7750161B2 (https=)
EP (1) EP1670470B1 (https=)
JP (1) JP4851328B2 (https=)
KR (1) KR20070014108A (https=)
CN (1) CN1856305B (https=)
AR (1) AR045949A1 (https=)
AT (1) ATE427748T1 (https=)
AU (1) AU2004275488A1 (https=)
BR (1) BRPI0414777A (https=)
CA (1) CA2540196C (https=)
DE (1) DE602004020486D1 (https=)
IL (1) IL174497A0 (https=)
MX (1) MXPA06003264A (https=)
NO (1) NO20061395L (https=)
RU (1) RU2006113948A (https=)
TW (1) TW200526630A (https=)
WO (1) WO2005030209A1 (https=)
ZA (1) ZA200602442B (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2520763A1 (en) 2003-04-03 2004-10-21 The Regents Of The University Of California Improved inhibitors for the soluble epoxide hydrolase
DE10358539A1 (de) * 2003-12-15 2005-07-07 Merck Patent Gmbh Carbonsäureamidderivate
EP1765311A4 (en) 2004-03-16 2009-04-29 Univ California REDUCTION OF NEPHROPATHY WITH INHIBITORS OF SOLUBLE EPOXY HYDROLASE AND EPOXYEICOSANOIDS
MX2007004293A (es) * 2004-10-12 2007-06-18 Actelion Pharmaceuticals Ltd 1[2-(4-bencil-4-hidroxi-piperidin-1-il)-etil]-3-(2-metil-quinolin -4-il)-urea como la sal de sulfato cristalina.
TW200630337A (en) 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
US7662910B2 (en) 2004-10-20 2010-02-16 The Regents Of The University Of California Inhibitors for the soluble epoxide hydrolase
SE0403084D0 (sv) * 2004-12-17 2004-12-17 Astrazeneca Ab Chemical process
US20070043104A1 (en) * 2005-06-10 2007-02-22 Luthman Ingrid K UII-modulating compounds and their use
AR059826A1 (es) * 2006-03-13 2008-04-30 Univ California Inhibidores de urea conformacionalmente restringidos de epoxido hidrolasa soluble
WO2007110449A1 (en) 2006-03-29 2007-10-04 Euro-Celtique S.A. Benzenesulfonamide compounds and their use
TW200815353A (en) * 2006-04-13 2008-04-01 Euro Celtique Sa Benzenesulfonamide compounds and their use
US8937181B2 (en) * 2006-04-13 2015-01-20 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
ATE545647T1 (de) * 2006-12-22 2012-03-15 Actelion Pharmaceuticals Ltd 5,6,7,8-tetrahydro-imidazoä1,5-aüpyrazinderivat
US8399486B2 (en) 2007-04-09 2013-03-19 Purdue Pharma L.P. Benzenesulfonyl compounds and the use thereof
US8765736B2 (en) * 2007-09-28 2014-07-01 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
WO2009076512A1 (en) 2007-12-11 2009-06-18 Epix Delaware, Inc. Carboxamidξ compounds and their use as chemokine receptor agonists
EP2528604B1 (en) 2010-01-29 2017-11-22 The Regents of the University of California Acyl piperidine inhibitors of soluble epoxide hydrolase

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE903957A1 (en) 1989-11-06 1991-05-08 Sanofi Sa Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present
US6159700A (en) 1997-01-27 2000-12-12 Smithkline Beecham Corporation Method of finding agonist and antagonist to human and rat GPR14
AUPP003197A0 (en) 1997-09-03 1997-11-20 Fujisawa Pharmaceutical Co., Ltd. New heterocyclic compounds
US6331541B1 (en) * 1998-12-18 2001-12-18 Soo S. Ko N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
JP2002532427A (ja) * 1998-12-18 2002-10-02 デュポン ファーマシューティカルズ カンパニー ケモカイン受容体活性のモジュレーターとしてのｎ−ウレイドアルキルピペリジン
ATE321751T1 (de) 1999-07-28 2006-04-15 Kirin Brewery Harnstoffderivate als ccr-3 rezeptor-inhibitoren
ES2207566T3 (es) 1999-12-21 2004-06-01 Smithkline Beecham Corporation Derivados carboxamida de pirrolidina y piperidina como antagonistas del receptor de urotensina-ii.
WO2001045694A1 (en) 1999-12-21 2001-06-28 Smithkline Beecham Corporation Urotensin-ii receptor antagonists
JP2003518059A (ja) 1999-12-21 2003-06-03 スミスクライン・ビーチャム・コーポレイション ウロテンシン−ｉｉ受容体アンタゴニスト
AU2001236100A1 (en) 2000-03-07 2001-09-17 Takeda Chemical Industries Ltd. Vasoactive agents
WO2001098269A2 (en) * 2000-06-21 2001-12-27 Bristol-Myers Squibb Pharma Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
EP1295867A4 (en) 2000-06-28 2005-03-30 Takeda Pharmaceutical BIPHENYL COMPOUND
CA2414976A1 (en) 2000-07-04 2002-01-10 Takeda Chemical Industries, Ltd. Gpr14 antagonistic agent
AU2002226048A1 (en) 2000-12-11 2002-06-24 Smith Kline Beecham Corporation Urotensin-ii receptor antagonists
US20040053963A1 (en) 2000-12-11 2004-03-18 Dashyant Dhanak Urotensin-II receptor antagonists
JP2004524295A (ja) 2001-01-26 2004-08-12 スミスクライン・ビーチャム・コーポレイション ウロテンシン−ｉｉ受容体アンタゴニスト
NZ527276A (en) * 2001-03-27 2004-11-26 Actelion Pharmaceuticals Ltd 1,2,3,4-tetrahydroisoquinoline derivatives as urotensin II receptor antagonists
JP2004529134A (ja) 2001-03-29 2004-09-24 スミスクライン・ビーチャム・コーポレイション ピロリジンスルホンアミド
US20040152692A1 (en) 2001-03-29 2004-08-05 Dashyant Dhanak Pyrrolidine sulfonamides
JP2004524355A (ja) 2001-03-29 2004-08-12 スミスクライン・ビーチャム・コーポレイション ピロリジンスルホンアミド
EP1379519A1 (en) 2001-03-29 2004-01-14 SmithKline Beecham Corporation Pyrrolidine sulfonamides
WO2002089793A1 (en) 2001-05-07 2002-11-14 Smithkline Beecham Corporation Sulfonamides
JP2004529168A (ja) 2001-05-07 2004-09-24 スミスクライン・ビーチャム・コーポレイション スルホンアミド
JP2004529170A (ja) 2001-05-07 2004-09-24 スミスクライン・ビーチャム・コーポレイション スルホンアミド
AR033879A1 (es) 2001-05-07 2004-01-07 Smithkline Beecham Corp Compuesto sulfonamida, composicion farmaceutica que lo comprende, su uso para preparar dicha composicion y procedimiento para la obtencion de dicho compuesto
JP2004535390A (ja) 2001-05-07 2004-11-25 スミスクライン・ビーチャム・コーポレイション スルホンアミド
EP1385495A4 (en) 2001-05-07 2005-12-21 Smithkline Beecham Corp SULPHONAMIDES
WO2003048154A1 (en) 2001-12-04 2003-06-12 Actelion Pharmaceuticals Ltd 4-(piperidyl- and pyrrolidyl-alkyl-ureido) -quinolines as urotensin ii receptor antagonists
JP2006505533A (ja) * 2002-09-17 2006-02-16 アクテリオン　ファマシューティカルズ　リミテッド １−ピリジン−４−イル−尿素誘導体
WO2004043366A2 (en) 2002-11-06 2004-05-27 Smithkline Beecham Corporation Sulfonamides
TW200418831A (en) 2002-11-06 2004-10-01 Smithkline Beecham Corp Sulfonamides
AU2003295408A1 (en) 2002-11-06 2004-06-03 Smithkline Beecham Corporation Sulfonamides
AU2003291262A1 (en) 2002-11-06 2004-06-03 Smithkline Beecham Corporation Sulfonamides
AU2003291255A1 (en) 2002-11-06 2004-06-03 Smithkline Beecham Corporation Sulfonamides
US7319111B2 (en) 2003-02-20 2008-01-15 Encysive Pharmaceuticals, Inc. Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists
WO2004099179A1 (en) 2003-05-07 2004-11-18 Actelion Pharmaceuticals Ltd Piperazine-alkyl-ureido derivatives

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NO20061395L (no) 2006-06-22
IL174497A0 (en) 2006-08-01
KR20070014108A (ko) 2007-01-31
ATE427748T1 (de) 2009-04-15
MXPA06003264A (es) 2006-06-08
JP4851328B2 (ja) 2012-01-11
WO2005030209A1 (en) 2005-04-07
EP1670470A1 (en) 2006-06-21
EP1670470B1 (en) 2009-04-08
AU2004275488A1 (en) 2005-04-07
RU2006113948A (ru) 2007-11-10
BRPI0414777A (pt) 2006-11-21
US7750161B2 (en) 2010-07-06
DE602004020486D1 (de) 2009-05-20
US20070043081A1 (en) 2007-02-22
ZA200602442B (en) 2007-09-26
AR045949A1 (es) 2005-11-16
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