CN1852926B - 由肝素衍生的寡糖混合物、其制备方法与含有所述混合物的药物组合物 - Google Patents

由肝素衍生的寡糖混合物、其制备方法与含有所述混合物的药物组合物 Download PDF

Info

Publication number
CN1852926B
CN1852926B CN2004800265420A CN200480026542A CN1852926B CN 1852926 B CN1852926 B CN 1852926B CN 2004800265420 A CN2004800265420 A CN 2004800265420A CN 200480026542 A CN200480026542 A CN 200480026542A CN 1852926 B CN1852926 B CN 1852926B
Authority
CN
China
Prior art keywords
molecular weight
preparation
activity
heparin
oligosaccharide mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2004800265420A
Other languages
English (en)
Chinese (zh)
Other versions
CN1852926A (zh
Inventor
V·劳克斯
P·穆里耶
C·维斯科夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Publication of CN1852926A publication Critical patent/CN1852926A/zh
Application granted granted Critical
Publication of CN1852926B publication Critical patent/CN1852926B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2004800265420A 2003-07-24 2004-07-22 由肝素衍生的寡糖混合物、其制备方法与含有所述混合物的药物组合物 Expired - Fee Related CN1852926B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0309041A FR2857971B1 (fr) 2003-07-24 2003-07-24 Melanges d'oligosaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
FR0309041 2003-07-24
PCT/FR2004/001943 WO2005010051A2 (fr) 2003-07-24 2004-07-22 Melanges d'oligosaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant

Publications (2)

Publication Number Publication Date
CN1852926A CN1852926A (zh) 2006-10-25
CN1852926B true CN1852926B (zh) 2010-05-12

Family

ID=33561051

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2004800265420A Expired - Fee Related CN1852926B (zh) 2003-07-24 2004-07-22 由肝素衍生的寡糖混合物、其制备方法与含有所述混合物的药物组合物

Country Status (39)

Country Link
EP (1) EP1651677B1 (enExample)
JP (1) JP4865552B2 (enExample)
KR (1) KR101125517B1 (enExample)
CN (1) CN1852926B (enExample)
AR (1) AR045917A1 (enExample)
AT (1) ATE487741T1 (enExample)
AU (1) AU2004259111B2 (enExample)
BR (1) BRPI0412850A (enExample)
CA (1) CA2533555A1 (enExample)
CR (1) CR8201A (enExample)
CY (1) CY1111165T1 (enExample)
DE (1) DE602004030015D1 (enExample)
DK (1) DK1651677T3 (enExample)
EC (1) ECSP066305A (enExample)
ES (1) ES2355827T3 (enExample)
FR (1) FR2857971B1 (enExample)
GT (1) GT200400145A (enExample)
HN (1) HN2004000250A (enExample)
IL (1) IL173206A (enExample)
MA (1) MA27928A1 (enExample)
ME (1) MEP11608A (enExample)
MX (1) MXPA06000336A (enExample)
MY (1) MY136769A (enExample)
NO (1) NO20060821L (enExample)
NZ (1) NZ544717A (enExample)
OA (1) OA13197A (enExample)
PA (1) PA8606801A1 (enExample)
PE (1) PE20050246A1 (enExample)
PL (1) PL1651677T3 (enExample)
PT (1) PT1651677E (enExample)
RS (1) RS20060044A (enExample)
RU (1) RU2346005C2 (enExample)
SI (1) SI1651677T1 (enExample)
TN (1) TNSN06025A1 (enExample)
TW (1) TWI369208B (enExample)
UA (1) UA89356C2 (enExample)
UY (1) UY28435A1 (enExample)
WO (1) WO2005010051A2 (enExample)
ZA (1) ZA200600657B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7589145B2 (en) 2004-04-15 2009-09-15 Exxonmobil Chemical Patents Inc. Syndiotactic rich polyolefins
EP2447285A3 (en) * 2006-05-25 2013-01-16 Momenta Pharmaceuticals, Inc. Low molecular weight heparin composition and uses thereof
CN101711771B (zh) * 2008-10-07 2015-12-09 上海喜恩医药科技发展有限公司 一种肝素衍生的多糖混合物及其制法和药物组合物
DK3144325T3 (da) * 2010-09-14 2021-01-25 Univ Miyazaki Heparin med høj renhed og fremstillingsfremgangsmåde dertil
WO2012072799A1 (en) 2010-12-02 2012-06-07 Aventis Pharma S.A. New methods for the in vitro measurement of the biological activity of an ultra low molecular weight heparin sample
CN102558392A (zh) * 2010-12-14 2012-07-11 王芃 一种高抗FXa、低抗FIIa低分子肝素钠的制备方法
CN102816255B (zh) * 2011-06-10 2015-11-25 王芃 一种超低分子肝素钠的制备方法
EP2980103B1 (en) 2013-03-26 2020-11-04 Jiuzhitang Co., Ltd. Low molecular weight glycosaminoglycan derivative, pharmaceutical composition thereof, preparation method therefor and use thereof
CN103864959A (zh) * 2014-04-03 2014-06-18 中国药科大学 一种肝素十二糖抗动脉粥样硬化的用途
RU2639574C2 (ru) * 2016-05-23 2017-12-21 Алексей Георгиевич Александров Способ получения низкомолекулярного гепарина

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998055515A1 (en) * 1997-06-06 1998-12-10 Hamilton Civic Hospitals Research Development, Inc. Modified low molecular weight heparin that inhibits clot associated coagulation factors
US6384021B1 (en) * 1999-07-23 2002-05-07 Laboratorios Farmaceuticos Rovi Heparin compositions of very low molecular weight
US20020055621A1 (en) * 2000-07-21 2002-05-09 Jacques Diaz Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
CN1379781A (zh) * 1999-10-22 2002-11-13 阿文蒂斯药物股份有限公司 新的低聚糖、其制备方法及其药物组合物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL61201A (en) * 1979-10-05 1984-09-30 Choay Sa Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them
FR2504928A1 (fr) * 1981-04-29 1982-11-05 Choay Sa Oligosaccharides a chaines courtes possedant des proprietes biologiques, leur preparation et leurs applications en tant que medicaments
FR2669932B1 (fr) * 1990-12-03 1994-07-01 Sanofi Sa Nouvel heparosane-n,o-sulfate, son procede de preparation et les compositions pharmaceutiques qui le contiennent.
IT1284143B1 (it) * 1996-09-06 1998-05-08 Istituto Scient Di Chimica E B Eparansolfati semi-sintetici ad elevata attivita' antimetastica e ridotto rischio emorragico
JP4897991B2 (ja) * 1999-07-23 2012-03-14 ラボラトリオス ファルマセウティコス ロビ ソシエダッド アノニマ 超低分子量ヘパリン組成物
JP4585072B2 (ja) * 2000-02-29 2010-11-24 扶桑薬品工業株式会社 ヘパリン解重合法、解重合ヘパリン、その誘導体および医薬組成物
FR2807043B1 (fr) * 2000-03-28 2002-11-22 Aventis Pharma Sa Composition pharmaceutique contenant des oligosaccharides, les nouveaux oligosaccharides et leur preparation
FR2811992B1 (fr) * 2000-07-21 2003-07-04 Aventis Pharma Sa Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
CA2458852A1 (en) * 2001-08-28 2003-03-06 Leo Pharma A/S Antithrombotic compositions comprising low molecular weight heparin and low molecular weight dermatan sulphate
FR2845686B1 (fr) * 2002-10-10 2013-08-30 Aventis Pharma Sa Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998055515A1 (en) * 1997-06-06 1998-12-10 Hamilton Civic Hospitals Research Development, Inc. Modified low molecular weight heparin that inhibits clot associated coagulation factors
US6384021B1 (en) * 1999-07-23 2002-05-07 Laboratorios Farmaceuticos Rovi Heparin compositions of very low molecular weight
CN1379781A (zh) * 1999-10-22 2002-11-13 阿文蒂斯药物股份有限公司 新的低聚糖、其制备方法及其药物组合物
US20020055621A1 (en) * 2000-07-21 2002-05-09 Jacques Diaz Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Jean Choay, et al..Structural studies on a biologically active hexasaccharideobtained from heparin.Annals New York Academy of Sciences370.1981,370644-649. *

Also Published As

Publication number Publication date
EP1651677A2 (fr) 2006-05-03
MXPA06000336A (es) 2006-03-30
TW200522970A (en) 2005-07-16
KR20060059974A (ko) 2006-06-02
JP2006528614A (ja) 2006-12-21
IL173206A (en) 2010-11-30
PE20050246A1 (es) 2005-06-02
NZ544717A (en) 2009-09-25
SI1651677T1 (sl) 2011-03-31
GT200400145A (es) 2005-03-16
AU2004259111A1 (en) 2005-02-03
AR045917A1 (es) 2005-11-16
RU2006105384A (ru) 2007-09-10
UA89356C2 (ru) 2010-01-25
CN1852926A (zh) 2006-10-25
ES2355827T3 (es) 2011-03-31
CY1111165T1 (el) 2015-06-11
DE602004030015D1 (de) 2010-12-23
WO2005010051A3 (fr) 2005-06-16
PT1651677E (pt) 2011-02-08
ATE487741T1 (de) 2010-11-15
AU2004259111B2 (en) 2009-06-11
KR101125517B1 (ko) 2012-03-23
ECSP066305A (es) 2006-07-28
IL173206A0 (en) 2006-06-11
ZA200600657B (en) 2007-05-30
PA8606801A1 (es) 2005-02-04
DK1651677T3 (da) 2011-02-28
RU2346005C2 (ru) 2009-02-10
CR8201A (es) 2006-09-22
MEP11608A (en) 2010-06-10
JP4865552B2 (ja) 2012-02-01
BRPI0412850A (pt) 2006-10-03
WO2005010051A2 (fr) 2005-02-03
TNSN06025A1 (en) 2007-10-03
PL1651677T3 (pl) 2011-04-29
TWI369208B (en) 2012-08-01
FR2857971B1 (fr) 2005-08-26
CA2533555A1 (fr) 2005-02-03
NO20060821L (no) 2006-04-20
HK1094806A1 (zh) 2007-04-13
RS20060044A (sr) 2008-06-05
EP1651677B1 (fr) 2010-11-10
MA27928A1 (fr) 2006-06-01
UY28435A1 (es) 2005-02-28
HN2004000250A (es) 2006-06-29
OA13197A (fr) 2006-12-13
MY136769A (en) 2008-11-28
FR2857971A1 (fr) 2005-01-28

Similar Documents

Publication Publication Date Title
JP5389140B2 (ja) ヘパリン誘導多糖類混合物、その製造およびそれを含有する医薬組成物
EP2794666B1 (en) Use of chemically modified heparin derivates in sickle cell disease
KR100853585B1 (ko) 헤파린-유래 폴리사카라이드 혼합물, 이의 제조방법 및이를 함유하는 약학 조성물
US20110152509A1 (en) Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
CN1852926B (zh) 由肝素衍生的寡糖混合物、其制备方法与含有所述混合物的药物组合物
US12280072B2 (en) Oligosaccharide compound for inhibiting intrinsic coagulation factor X-enzyme complex, and preparation method therefor and uses thereof
HK1094806B (en) Heparin-derived oligosaccharide mixtures, preparation thereof and pharmaceutical compositions containing said mixtures
KR101104107B1 (ko) 헤파린으로부터 유도된 다당류의 혼합물, 이의 제조방법 및이를 함유하는 약제학적 조성물
HK1145031A (en) Heparin-derived polysaccharide mixtures, preparation thereof and pharmaceutical compositions containing same
HK1145030A (en) Heparin-derived polysaccharide mixtures, preparation thereof and pharmaceutical compositions containing same
HK1145015A (en) Heparin-derived polysaccharide mixtures, preparation thereof and pharmaceutical compositions containing same
HK1145026A (en) Heparin-derived polysaccharide mixtures, preparation thereof and pharmaceutical compositions containing same
HK1199893B (en) Use of chemically modified heparin derivates in sickle cell disease

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1094806

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1094806

Country of ref document: HK

C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20100512

Termination date: 20130722