ATE487741T1 - Mischungen aus von heparin abgeleiteten oligosacchariden, herstellung davon und pharmazeutische zusammensetzungen, die die mischungen enthalten - Google Patents

Mischungen aus von heparin abgeleiteten oligosacchariden, herstellung davon und pharmazeutische zusammensetzungen, die die mischungen enthalten

Info

Publication number
ATE487741T1
ATE487741T1 AT04785991T AT04785991T ATE487741T1 AT E487741 T1 ATE487741 T1 AT E487741T1 AT 04785991 T AT04785991 T AT 04785991T AT 04785991 T AT04785991 T AT 04785991T AT E487741 T1 ATE487741 T1 AT E487741T1
Authority
AT
Austria
Prior art keywords
mixtures
heparin
production
pharmaceutical compositions
compositions containing
Prior art date
Application number
AT04785991T
Other languages
German (de)
English (en)
Inventor
Volker Laux
Pierre Mourier
Christian Viskov
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of ATE487741T1 publication Critical patent/ATE487741T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT04785991T 2003-07-24 2004-07-22 Mischungen aus von heparin abgeleiteten oligosacchariden, herstellung davon und pharmazeutische zusammensetzungen, die die mischungen enthalten ATE487741T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0309041A FR2857971B1 (fr) 2003-07-24 2003-07-24 Melanges d'oligosaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
PCT/FR2004/001943 WO2005010051A2 (fr) 2003-07-24 2004-07-22 Melanges d'oligosaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant

Publications (1)

Publication Number Publication Date
ATE487741T1 true ATE487741T1 (de) 2010-11-15

Family

ID=33561051

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04785991T ATE487741T1 (de) 2003-07-24 2004-07-22 Mischungen aus von heparin abgeleiteten oligosacchariden, herstellung davon und pharmazeutische zusammensetzungen, die die mischungen enthalten

Country Status (39)

Country Link
EP (1) EP1651677B1 (enExample)
JP (1) JP4865552B2 (enExample)
KR (1) KR101125517B1 (enExample)
CN (1) CN1852926B (enExample)
AR (1) AR045917A1 (enExample)
AT (1) ATE487741T1 (enExample)
AU (1) AU2004259111B2 (enExample)
BR (1) BRPI0412850A (enExample)
CA (1) CA2533555A1 (enExample)
CR (1) CR8201A (enExample)
CY (1) CY1111165T1 (enExample)
DE (1) DE602004030015D1 (enExample)
DK (1) DK1651677T3 (enExample)
EC (1) ECSP066305A (enExample)
ES (1) ES2355827T3 (enExample)
FR (1) FR2857971B1 (enExample)
GT (1) GT200400145A (enExample)
HN (1) HN2004000250A (enExample)
IL (1) IL173206A (enExample)
MA (1) MA27928A1 (enExample)
ME (1) MEP11608A (enExample)
MX (1) MXPA06000336A (enExample)
MY (1) MY136769A (enExample)
NO (1) NO20060821L (enExample)
NZ (1) NZ544717A (enExample)
OA (1) OA13197A (enExample)
PA (1) PA8606801A1 (enExample)
PE (1) PE20050246A1 (enExample)
PL (1) PL1651677T3 (enExample)
PT (1) PT1651677E (enExample)
RS (1) RS20060044A (enExample)
RU (1) RU2346005C2 (enExample)
SI (1) SI1651677T1 (enExample)
TN (1) TNSN06025A1 (enExample)
TW (1) TWI369208B (enExample)
UA (1) UA89356C2 (enExample)
UY (1) UY28435A1 (enExample)
WO (1) WO2005010051A2 (enExample)
ZA (1) ZA200600657B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7589145B2 (en) 2004-04-15 2009-09-15 Exxonmobil Chemical Patents Inc. Syndiotactic rich polyolefins
AU2007267561B2 (en) * 2006-05-25 2012-05-17 Momenta Pharmaceuticals, Inc. Low molecular weight heparin composition and uses thereof
CN101711771B (zh) * 2008-10-07 2015-12-09 上海喜恩医药科技发展有限公司 一种肝素衍生的多糖混合物及其制法和药物组合物
DK3144325T3 (da) * 2010-09-14 2021-01-25 Univ Miyazaki Heparin med høj renhed og fremstillingsfremgangsmåde dertil
WO2012072799A1 (en) 2010-12-02 2012-06-07 Aventis Pharma S.A. New methods for the in vitro measurement of the biological activity of an ultra low molecular weight heparin sample
CN102558392A (zh) * 2010-12-14 2012-07-11 王芃 一种高抗FXa、低抗FIIa低分子肝素钠的制备方法
CN102816255B (zh) * 2011-06-10 2015-11-25 王芃 一种超低分子肝素钠的制备方法
WO2014153995A1 (zh) * 2013-03-26 2014-10-02 中国科学院昆明植物研究所 一种低分子量糖胺聚糖衍生物及其药物组合物和其制备方法与应用
CN103864959A (zh) * 2014-04-03 2014-06-18 中国药科大学 一种肝素十二糖抗动脉粥样硬化的用途
RU2639574C2 (ru) * 2016-05-23 2017-12-21 Алексей Георгиевич Александров Способ получения низкомолекулярного гепарина

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL61201A (en) * 1979-10-05 1984-09-30 Choay Sa Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them
FR2504928A1 (fr) * 1981-04-29 1982-11-05 Choay Sa Oligosaccharides a chaines courtes possedant des proprietes biologiques, leur preparation et leurs applications en tant que medicaments
FR2669932B1 (fr) * 1990-12-03 1994-07-01 Sanofi Sa Nouvel heparosane-n,o-sulfate, son procede de preparation et les compositions pharmaceutiques qui le contiennent.
IT1284143B1 (it) * 1996-09-06 1998-05-08 Istituto Scient Di Chimica E B Eparansolfati semi-sintetici ad elevata attivita' antimetastica e ridotto rischio emorragico
US6075013A (en) * 1997-06-06 2000-06-13 Hamilton Civic Hospitals Research Development Inc. Modified low molecular weight heparin that inhibits clot associated coagulation factors
JP4897991B2 (ja) * 1999-07-23 2012-03-14 ラボラトリオス ファルマセウティコス ロビ ソシエダッド アノニマ 超低分子量ヘパリン組成物
ES2161615B1 (es) * 1999-07-23 2003-03-16 Rovi Lab Farmaceut Sa Composiciones de heparinas de muy bajo peso molecular.
FR2800074B1 (fr) * 1999-10-22 2001-12-21 Aventis Pharma Sa Nouveaux oligosaccharides, leur preparation et les compositions pharmaceutiques les contenant
JP4585072B2 (ja) * 2000-02-29 2010-11-24 扶桑薬品工業株式会社 ヘパリン解重合法、解重合ヘパリン、その誘導体および医薬組成物
FR2807043B1 (fr) * 2000-03-28 2002-11-22 Aventis Pharma Sa Composition pharmaceutique contenant des oligosaccharides, les nouveaux oligosaccharides et leur preparation
FR2811992B1 (fr) * 2000-07-21 2003-07-04 Aventis Pharma Sa Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
US6969705B2 (en) * 2000-07-21 2005-11-29 Aventis Pharma S.A. Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
WO2003018032A1 (en) * 2001-08-28 2003-03-06 Leo Pharma A/S Antithrombotic compositions comprising low molecular weight heparin and low molecular weight dermatan sulphate
FR2845686B1 (fr) * 2002-10-10 2013-08-30 Aventis Pharma Sa Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
MXPA06000336A (es) 2006-03-30
IL173206A (en) 2010-11-30
MA27928A1 (fr) 2006-06-01
PE20050246A1 (es) 2005-06-02
ZA200600657B (en) 2007-05-30
IL173206A0 (en) 2006-06-11
PA8606801A1 (es) 2005-02-04
UY28435A1 (es) 2005-02-28
JP2006528614A (ja) 2006-12-21
FR2857971A1 (fr) 2005-01-28
WO2005010051A2 (fr) 2005-02-03
EP1651677B1 (fr) 2010-11-10
OA13197A (fr) 2006-12-13
RS20060044A (sr) 2008-06-05
CA2533555A1 (fr) 2005-02-03
WO2005010051A3 (fr) 2005-06-16
PL1651677T3 (pl) 2011-04-29
KR101125517B1 (ko) 2012-03-23
GT200400145A (es) 2005-03-16
EP1651677A2 (fr) 2006-05-03
DE602004030015D1 (de) 2010-12-23
TWI369208B (en) 2012-08-01
NZ544717A (en) 2009-09-25
AR045917A1 (es) 2005-11-16
TNSN06025A1 (en) 2007-10-03
HN2004000250A (es) 2006-06-29
HK1094806A1 (zh) 2007-04-13
AU2004259111A1 (en) 2005-02-03
AU2004259111B2 (en) 2009-06-11
CY1111165T1 (el) 2015-06-11
PT1651677E (pt) 2011-02-08
CN1852926B (zh) 2010-05-12
UA89356C2 (ru) 2010-01-25
BRPI0412850A (pt) 2006-10-03
RU2346005C2 (ru) 2009-02-10
TW200522970A (en) 2005-07-16
ES2355827T3 (es) 2011-03-31
JP4865552B2 (ja) 2012-02-01
MEP11608A (en) 2010-06-10
MY136769A (en) 2008-11-28
CN1852926A (zh) 2006-10-25
FR2857971B1 (fr) 2005-08-26
KR20060059974A (ko) 2006-06-02
ECSP066305A (es) 2006-07-28
NO20060821L (no) 2006-04-20
RU2006105384A (ru) 2007-09-10
SI1651677T1 (sl) 2011-03-31
DK1651677T3 (da) 2011-02-28
CR8201A (es) 2006-09-22

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