UY28435A1 - Mezclas de oligosacáridos derivados de la heparina, su preparación y las composiciones farmacéuticas que las contienen - Google Patents

Mezclas de oligosacáridos derivados de la heparina, su preparación y las composiciones farmacéuticas que las contienen

Info

Publication number
UY28435A1
UY28435A1 UY28435A UY28435A UY28435A1 UY 28435 A1 UY28435 A1 UY 28435A1 UY 28435 A UY28435 A UY 28435A UY 28435 A UY28435 A UY 28435A UY 28435 A1 UY28435 A1 UY 28435A1
Authority
UY
Uruguay
Prior art keywords
mixtures
pharmaceutical compositions
compositions containing
derived
oligosacarids
Prior art date
Application number
UY28435A
Other languages
English (en)
Inventor
Laux Volker
Mourier Pierre
Viskov Christian
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of UY28435A1 publication Critical patent/UY28435A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a mezclas de oligosacáridos derivados de la heparina que tiene un peso molecular medio de 1.800 a 2.400 Daltones, caracterizadas por una gran actividad aXa y una ausencia de actividad aIIa, a su procedimiento de preparación y a las composiciones farmacéuticas que las contiene.
UY28435A 2003-07-24 2004-07-23 Mezclas de oligosacáridos derivados de la heparina, su preparación y las composiciones farmacéuticas que las contienen UY28435A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0309041A FR2857971B1 (fr) 2003-07-24 2003-07-24 Melanges d'oligosaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant

Publications (1)

Publication Number Publication Date
UY28435A1 true UY28435A1 (es) 2005-02-28

Family

ID=33561051

Family Applications (1)

Application Number Title Priority Date Filing Date
UY28435A UY28435A1 (es) 2003-07-24 2004-07-23 Mezclas de oligosacáridos derivados de la heparina, su preparación y las composiciones farmacéuticas que las contienen

Country Status (40)

Country Link
EP (1) EP1651677B1 (es)
JP (1) JP4865552B2 (es)
KR (1) KR101125517B1 (es)
CN (1) CN1852926B (es)
AR (1) AR045917A1 (es)
AT (1) ATE487741T1 (es)
AU (1) AU2004259111B2 (es)
BR (1) BRPI0412850A (es)
CA (1) CA2533555A1 (es)
CR (1) CR8201A (es)
CY (1) CY1111165T1 (es)
DE (1) DE602004030015D1 (es)
DK (1) DK1651677T3 (es)
EC (1) ECSP066305A (es)
ES (1) ES2355827T3 (es)
FR (1) FR2857971B1 (es)
GT (1) GT200400145A (es)
HK (1) HK1094806A1 (es)
HN (1) HN2004000250A (es)
IL (1) IL173206A (es)
MA (1) MA27928A1 (es)
ME (1) MEP11608A (es)
MX (1) MXPA06000336A (es)
MY (1) MY136769A (es)
NO (1) NO20060821L (es)
NZ (1) NZ544717A (es)
OA (1) OA13197A (es)
PA (1) PA8606801A1 (es)
PE (1) PE20050246A1 (es)
PL (1) PL1651677T3 (es)
PT (1) PT1651677E (es)
RS (1) RS20060044A (es)
RU (1) RU2346005C2 (es)
SI (1) SI1651677T1 (es)
TN (1) TNSN06025A1 (es)
TW (1) TWI369208B (es)
UA (1) UA89356C2 (es)
UY (1) UY28435A1 (es)
WO (1) WO2005010051A2 (es)
ZA (1) ZA200600657B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7589145B2 (en) 2004-04-15 2009-09-15 Exxonmobil Chemical Patents Inc. Syndiotactic rich polyolefins
AU2007267561B2 (en) * 2006-05-25 2012-05-17 Momenta Pharmaceuticals, Inc. Low molecular weight heparin composition and uses thereof
CN101711771B (zh) * 2008-10-07 2015-12-09 上海喜恩医药科技发展有限公司 一种肝素衍生的多糖混合物及其制法和药物组合物
KR101794877B1 (ko) * 2010-09-14 2017-11-07 고쿠리츠 다이가쿠 호징 미야자키 다이가쿠 고순도 헤파린 및 그 제조방법
WO2012072799A1 (en) 2010-12-02 2012-06-07 Aventis Pharma S.A. New methods for the in vitro measurement of the biological activity of an ultra low molecular weight heparin sample
CN102558392A (zh) * 2010-12-14 2012-07-11 王芃 一种高抗FXa、低抗FIIa低分子肝素钠的制备方法
CN102816255B (zh) * 2011-06-10 2015-11-25 王芃 一种超低分子肝素钠的制备方法
EP2980103B1 (en) * 2013-03-26 2020-11-04 Jiuzhitang Co., Ltd. Low molecular weight glycosaminoglycan derivative, pharmaceutical composition thereof, preparation method therefor and use thereof
CN103864959A (zh) * 2014-04-03 2014-06-18 中国药科大学 一种肝素十二糖抗动脉粥样硬化的用途
RU2639574C2 (ru) * 2016-05-23 2017-12-21 Алексей Георгиевич Александров Способ получения низкомолекулярного гепарина

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL61201A (en) * 1979-10-05 1984-09-30 Choay Sa Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them
FR2504928A1 (fr) * 1981-04-29 1982-11-05 Choay Sa Oligosaccharides a chaines courtes possedant des proprietes biologiques, leur preparation et leurs applications en tant que medicaments
AU7753898A (en) * 1997-06-06 1998-12-21 Hamilton Civic Hospitals Research Development, Inc. Modified low molecular weight heparin that inhibits clot associated coagulation factors
ES2161615B1 (es) * 1999-07-23 2003-03-16 Rovi Lab Farmaceut Sa Composiciones de heparinas de muy bajo peso molecular.
JP4897991B2 (ja) * 1999-07-23 2012-03-14 ラボラトリオス ファルマセウティコス ロビ ソシエダッド アノニマ 超低分子量ヘパリン組成物
FR2800074B1 (fr) * 1999-10-22 2001-12-21 Aventis Pharma Sa Nouveaux oligosaccharides, leur preparation et les compositions pharmaceutiques les contenant
JP4585072B2 (ja) * 2000-02-29 2010-11-24 扶桑薬品工業株式会社 ヘパリン解重合法、解重合ヘパリン、その誘導体および医薬組成物
FR2807043B1 (fr) * 2000-03-28 2002-11-22 Aventis Pharma Sa Composition pharmaceutique contenant des oligosaccharides, les nouveaux oligosaccharides et leur preparation
FR2811992B1 (fr) * 2000-07-21 2003-07-04 Aventis Pharma Sa Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
US6969705B2 (en) * 2000-07-21 2005-11-29 Aventis Pharma S.A. Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
WO2003018032A1 (en) * 2001-08-28 2003-03-06 Leo Pharma A/S Antithrombotic compositions comprising low molecular weight heparin and low molecular weight dermatan sulphate
FR2845686B1 (fr) * 2002-10-10 2013-08-30 Aventis Pharma Sa Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
HK1094806A1 (en) 2007-04-13
ECSP066305A (es) 2006-07-28
CN1852926B (zh) 2010-05-12
CY1111165T1 (el) 2015-06-11
EP1651677A2 (fr) 2006-05-03
RU2346005C2 (ru) 2009-02-10
AR045917A1 (es) 2005-11-16
CR8201A (es) 2006-09-22
MXPA06000336A (es) 2006-03-30
TWI369208B (en) 2012-08-01
PT1651677E (pt) 2011-02-08
ES2355827T3 (es) 2011-03-31
CA2533555A1 (fr) 2005-02-03
NZ544717A (en) 2009-09-25
TW200522970A (en) 2005-07-16
PL1651677T3 (pl) 2011-04-29
HN2004000250A (es) 2006-06-29
SI1651677T1 (sl) 2011-03-31
FR2857971B1 (fr) 2005-08-26
IL173206A0 (en) 2006-06-11
TNSN06025A1 (en) 2007-10-03
NO20060821L (no) 2006-04-20
AU2004259111A1 (en) 2005-02-03
OA13197A (fr) 2006-12-13
FR2857971A1 (fr) 2005-01-28
JP2006528614A (ja) 2006-12-21
ATE487741T1 (de) 2010-11-15
AU2004259111B2 (en) 2009-06-11
DK1651677T3 (da) 2011-02-28
KR101125517B1 (ko) 2012-03-23
MY136769A (en) 2008-11-28
DE602004030015D1 (de) 2010-12-23
PE20050246A1 (es) 2005-06-02
ZA200600657B (en) 2007-05-30
PA8606801A1 (es) 2005-02-04
IL173206A (en) 2010-11-30
GT200400145A (es) 2005-03-16
BRPI0412850A (pt) 2006-10-03
JP4865552B2 (ja) 2012-02-01
WO2005010051A2 (fr) 2005-02-03
CN1852926A (zh) 2006-10-25
MA27928A1 (fr) 2006-06-01
MEP11608A (en) 2010-06-10
KR20060059974A (ko) 2006-06-02
EP1651677B1 (fr) 2010-11-10
RU2006105384A (ru) 2007-09-10
UA89356C2 (ru) 2010-01-25
WO2005010051A3 (fr) 2005-06-16
RS20060044A (en) 2008-06-05

Similar Documents

Publication Publication Date Title
ECSP066305A (es) Mezclas de oligosacáridos derivados de la heparina, su preparación y las composiciones farmacéuticas que las contienen
ECSP034442A (es) Mezclas de polisacaridos derivados de la heparina, su preparacion y las composiciones farmaceuticas que las contienen
NL300364I2 (nl) Geïnactiveerd split influenzavirus van influenzastam A/California/7/2009 (H1N1) (X-179A), desgewenst van een pandemische influenzastam in een officieel verklaarde pandemische situatie
MY142376A (en) Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
BR9913658A (pt) Frações de inulina, processo para a sua preparação e produtos alimentìcios contendo as ditas frações de inulina
CY1114504T1 (el) Συνθεσεις τιγεκυκλινης και μεθοδοι παρασκευης
CY1113105T1 (el) Παραγωγα ξανθινης, η παραγωγη αυτων και η χρηση αυτων ως φαρμακευτικα μεσα
EA199700347A1 (ru) Сульфатированный олигосахарид, его применение для лечения теплокровных животных и фармацевтическая композиция на его основе
HUP0204196A2 (hu) Antiangiogén aktivitással rendelkező és antikoaguláns hatástól mentes részlegesen deszulfatált glükózamininoglikán-származékok, eljárás előállításukra és ilyen vegyületeket tartalmazó gyógyászati készítmények
LTPA2018502I1 (lt) Per burną vartojamos kladribino kompozicijos
ECSP055586A (es) Proceso para producir una preparación de trombina con virus inactivados
CY1107294T1 (el) Τοπικη συνθεση η οποια περιεχει τουλαχιστον μια βιταμινη d ή ενα αναλογο της βιταμινης d και τουλαχιστον ενα κορτικοστεροειδες
DE60228184D1 (de) Verfahren zur Herstellung von Chondroitinsulfaten aus K4-Polysaccharid und so hergestellte Produkte
ATE428093T1 (de) Prallflache
BRPI0606619A2 (pt) método de análise de oligossacarìdeos, a partir do plasma sangüìneo
EA200300727A1 (ru) Производные 2h-1-бензопирана, способы их получения и их фармацевтические композиции
ATE402140T1 (de) Cyclopentyl sulfonamid derivaten
CL2004001348A1 (es) Composicion farmaceutica o alimenticia que comprende glucano derivado de microalgas o microalgas que lo contienen, la cual tiene efectos inmunoestimulantes, profilacticos y/o de crecimiento aumentando la resistencia contra enfermedades causadas por m
IL175558A0 (en) A universally applicable virus inactivated blood plasma produced from portions of non-caucasian plasma
CY1105106T1 (el) Συνδυασμος ενος αντιθρομβωτικου και ασπιρινης και η χρηση τους για την θεραπεια θρομβωτικων και αρτηριοσκληρωτικων ασθενειων
ATE370969T1 (de) Niedermolekulare peptidderivate als inhibitoren der laminin/nidogen wechselwirkung
BR0011543A (pt) Processo de estágios múltiplos para produção de microcápsulas enchidas com gás
BRPI0410638A (pt) derivados de azitromicina
WO2003074570A1 (fr) Nouvelles molecules de sialo-sucre ramifiees et agents antiviraux les utilisant
AR041555A1 (es) Mezclas de polisacaridos derivados de heparina, su preparacion y las composiciones farmaceuticas que las contienen