CN1846780A - Anticancer analgetic Chinese medicine composition and its prepn process - Google Patents
Anticancer analgetic Chinese medicine composition and its prepn process Download PDFInfo
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Abstract
The anticancer analgetic Chinese medicine composition is prepared with the extracts of ten kinds of Chinese medicinal materials, including oldenlandia, celandine, Chuanxiong rhizome, etc. as well as other seven kinds of Chinese medicinal materials, including pleion rhizome, kaempferia galamga, frankincense, etc. It has united functions of strengthening body's resistance and eliminating evil, and excellent anticancer and analgetic effect. The present invention also discloses the preparation process of the anticancer analgetic Chinese medicine composition.
Description
Technical field
What the present invention relates to is a kind of anticancer analgesic Chinese medicine composition, the invention still further relates to the preparation method of this anticancer analgesic Chinese medicine composition.
Background technology
Malignant tumor is the commonly encountered diseases of serious harm human health and life, and it is followed violent and persistent pain takes place, and has a strong impact on patient's life quality especially.The Western medicine analgesic of the morphine of now always continuing to use and dolantin and so on, addiction that it is serious and toleration and withdrawal symptom are difficult to be accepted by the patient.
Doctor trained in Western medicine is that this no doubt shows the advance of its modern medicine based on operation, chemotherapy and radiation to the treatment of malignant tumor, but also has many unsatisfactory places simultaneously really.Motherland's traditional medicine then is with determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs comparatively speaking, and whole therapy is main, in the field that human and cancer are struggled, demonstrates its characteristic and strong point day by day.
During the cancerous pain pilosity is born in, patient with advanced cancer, belong to " pain disease " category of the traditional Chinese medical science.Motherland's traditional medicine is thought, the generation of cancerous pain and loses through gas that defeated, blood capablely is obstructed, deficiency of vital QI is relevant, and the method for treatment such as intestinal stasis relieving, blood circulation promoting and blood stasis dispelling, benefiting qi and nourishing blood, hard masses softening and resolving of therefore taking to regulate the flow of vital energy have obtained gratifying effect, have caused common people's concern.
Summary of the invention
The objective of the invention is to overcome above-mentioned existing disadvantages of background technology part, and a kind of anticancer analgesic Chinese medicine composition is provided.
Another object of the present invention provides the preparation method of this anticancer analgesic Chinese medicine composition, enables cancerous pain is carried out treating both the principal and secondary aspects of a disease, reaches good anticancer analgesic effect.
Medicine of the present invention is to filter out following 17 flavor Chinese herbal medicine from numerous Chinese herbal medicine, and they are: Herba Hedyotidis Diffusae, Herba Chelidonii, Camptotheca acuminata root, Rhizoma Chuanxiong, Rhizoma Curcumae, Semen Coicis, Radix Pseudostellariae, Ganoderma lucidum seu Japonicum, Herba Crotalariae sessiliflorae, the Radix Astragali, Pseudobulbus cremastrae seu pleiones, Rhizoma Kaempferiae, Semen Momordicae, Semen Strychni, Resina garciniae, Venenum Bufonis, Olibanum.This 17 flavor Chinese herbal medicine is carried out the process of preparing Chinese medicine and the extraction of science, make to produce synergy between the medicine, thereby reach good anticancer analgesic effect.
The effect of this 17 flavor Chinese herbal medicine is respectively: Herba Hedyotidis Diffusae: heat-clearing and toxic substances removing, the diuretic removing food stagnancy is to mouse cervical cancer U
14Inhibitory action is arranged, and can stimulate reticuloendothelial system, strengthen leukocytic phagocytic activity.Herba Chelidonii: the removing blood stasis detumescence, hemostatic analgesia, its alkaloid have stronger anticancer analgesic effect.Camptotheca acuminata root: contain multiple alkaloid, have the eliminating stagnation eliminating mass, to cerebroma-22, W-256 has stronger inhibitory action.Rhizoma Chuanxiong: blood-activating and qi-promoting, wind-expelling pain-stopping.Rhizoma Curcumae: circulation of qi promoting removing blood stasis, blood stasis dispelling removing food stagnancy, to experimental animal models S
180, ECL
15, U
14, S
37Inhibitory action is arranged.Semen Coicis: spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, removing toxic substances and promoting pus discharge is to zoopery tumor S
180, YAS has inhibitory action.Radix Pseudostellariae: replenishing QI to invigorate the spleen, promoting the production of body fluid for nourishing the lung, its Saponin, polysaccharide and steroidal compounds are to ECA tumor, sarcoma S
180, adenocarcinoma 755 has inhibitory action, also has good enhancing human body immunity function, promotes leukopoietic effect.Ganoderma lucidum seu Japonicum: strengthening by means of tonics, relieving cough and asthma, to murine sarcoma S
180Inhibitory action is arranged, and the pair cell immunity has regulating action.Herba Crotalariae sessiliflorae: heat-clearing and toxic substances removing, dampness removing removing food stagnancy, contain 7 kinds of alkaloids, to murine sarcoma-180, leukemia-615, S37 has stronger inhibitory action.The Radix Astragali: invigorating QI to consolidate the body surface resistance, the Tuoli granulation promoting, inducing diuresis to remove edema is to murine sarcoma S
180Inhibitory action is arranged, and pair cell immunity and humoral immunization have regulating action.Pseudobulbus cremastrae seu pleiones: hard masses softening and resolving, removing toxic substances and promoting subsidence of swelling, to murine sarcoma S
180, S
37Rat W
256Inhibitory action is arranged.Rhizoma Kaempferiae: circulation of qi promoting warming middle-JIAO, the pain relieving that helps digestion, gas fragrance is special, has the tying-in effect, and alternative Moschus uses.Semen Momordicae: mass dissipating and swelling eliminating, counteracting toxic substances are treated skin ulcer, and modern pharmacological research proves that this medicine has the effect of broad-spectrum anticancer analgesic.Semen Strychni: removing obstruction in the collateral to relieve pain, mass dissipating and swelling eliminating, its alkaloid is to murine sarcoma S
180, the leukaemia has inhibitory action.Resina garciniae: counteracting toxic substances detumescence, hemostatic analgesia experimental results show that this medicine all has the obvious suppression effect to ehrlich ascites cell and 6 strain animal tumor bodies.Venenum Bufonis: the detoxifcation pain relieving, have one's ideas straightened out and refresh oneself, to murine sarcoma S
180With rabbit BP tumor inhibitory action is arranged.Olibanum: promoting blood circulation and stopping pain, detumescence and promoting granulation is to murine sarcoma S
180Inhibitory action is arranged.
The consumption of each component of the present invention is groped to sum up out through the inventor for a long time, in a large number, and the each component consumption all has curative effect preferably in following weight percentage ranges.
Different according to the character of medicine and preparation method are divided into 3 components with above-mentioned 17 flavor Chinese herbal medicine, and the 1st, 2 components are the extract of Chinese herbal medicine, and the 3rd component is the brewage of Chinese herbal medicine.
The 1st component: Herba Hedyotidis Diffusae extract 9%, Herba Chelidonii extract 8%, Camptotheca acuminata root extract 5%, Rhizoma Chuanxiong extract 7%, Rhizoma Curcumae extract 5%, Semen Coicis extract 5%, the open country is closed extract 4% in vain.
The 2nd component: Radix Pseudostellariae extract 5%, Ganoderma lucidum seu Japonicum extract 5%, Radix Astragali extract 8%.
The 3rd component: Semen Momordicae frost 10%, Semen Strychni (processed) 3%, Resina garciniae (processed) 0.5%, Venenum Bufonis (processed with wine) 0.5%, Olibanum (processed) 6%, Rhizoma Kaempferiae 10%, Pseudobulbus cremastrae seu pleiones 9%.
Crude drug and hundred parts of ratios of weight thereof of making Chinese medicine composition active ingredient of the present invention are: Herba Hedyotidis Diffusae extract 9%, Herba Chelidonii extract 8%, Camptotheca acuminata root extract 5%, Rhizoma Chuanxiong extract 7%, Rhizoma Curcumae extract 5%, Semen Coicis extract 5%, Radix Pseudostellariae extract 5%, Ganoderma lucidum seu Japonicum extract 5%, Herba Crotalariae sessiliflorae extract 4%, Radix Astragali extract 8%; Pseudobulbus cremastrae seu pleiones 9%; Rhizoma Kaempferiae 10%, Semen Momordicae frost 10%, Semen Strychni (processed) 3%, Resina garciniae (processed) 0.5%, Venenum Bufonis (processed with wine) 0.50%, Olibanum 6%.
Chinese medicine composition of the present invention can adopt the conventional method of Chinese medicine preparation to make any conventional oral preparations, as makes capsule, granule, tablet etc., but this does not limit protection scope of the present invention.
The method for preparing anticancer analgesic Chinese medicinal composition capsules of the present invention agent is:
A) take by weighing above-mentioned Chinese medicine in proportion, and above-mentioned Chinese medicine is divided into three components, the 1st component Chinese medicine is: Herba Hedyotidis Diffusae, Herba Chelidonii, Rhizoma Chuanxiong, Rhizoma Curcumae, Semen Coicis, Camptotheca acuminata root, Herba Crotalariae sessiliflorae, and the crude drug of each Chinese medicine in described the 1st component: 5 times by extracts from crude drugs weight take by weighing; The 2nd component Chinese medicine is: Radix Pseudostellariae, Ganoderma lucidum seu Japonicum, the Radix Astragali, and the crude drug of each Chinese medicine in described the 2nd component: 5 times by extracts from crude drugs weight take by weighing; The 3rd component Chinese medicine is: Pseudobulbus cremastrae seu pleiones, Rhizoma Kaempferiae, Semen Momordicae, Semen Strychni, Resina garciniae, Venenum Bufonis, Olibanum; Pseudobulbus cremastrae seu pleiones, Rhizoma Kaempferiae, Olibanum took by weighing by 1: 1 in described the 3rd component; Described Semen Momordicae: the taking by weighing of Semen Momordicae frost by 10: 8; Described Semen Strychni: the taking by weighing of Semen Strychni (processed) by 10: 6; Described Resina garciniae (processed), Venenum Bufonis (processed with wine), Olibanum all take by weighing in 1: 1 ratio;
B) the 1st component Chinese medicine Herba Hedyotidis Diffusae, Herba Chelidonii, Rhizoma Chuanxiong, Rhizoma Curcumae, Semen Coicis, Camptotheca acuminata root, Herba Crotalariae sessiliflorae are mixed, add total amount 5-8 water doubly, be heated to boiling, kept 1 hour, and poured out medicinal liquid, again Chinese medicine is decocted once again, pour out medicinal liquid, mix stirring with the 1st decocting liquid, it is concentrated to heat, 95% ethanol that adds 2 times of amounts after cooling mixes and stirs, and leaves standstill and removes precipitation, heating makes it remain on 78-79 ℃, fractionates out ethanol, makes extractum, after the drying, pulverized, crossed 80 mesh sieves;
C) Radix Pseudostellariae, Ganoderma lucidum seu Japonicum, the Radix Astragali are extracted with percolation: earlier Chinese medicine is broken into coarse powder, airtight with 75% the moistening back of ethanol of equivalent, placed 3 hours, in the percolator of then the spice gradation after the moistening expansion being packed into; Open percolator immersion outlet piston,, in percolator, put into 75% ethanol then, cover with gauze above, compress, add a cover and placed 24 hours with surplus air in the expelling tube; Percolate is controlled in the flow velocity of per minute 5mL, and constantly replenishes 75% ethanol, active ingredient is fully leached in medical material; Collect whole leachates, low-press thick shortens extractum into then, and oven dry is pulverized;
D) Pseudobulbus cremastrae seu pleiones, Rhizoma Kaempferiae are cleaned out, removal of contamination is ground into smalls, crosses 80 mesh sieves;
E) Semen Momordicae is made the Semen Momordicae frost: get clean Semen Momordicae and shell and get core, fry and grind the end, with several layers of toilet paper parcels, add burlap and pack tightly, squeezing is deoiled, repeated multiple times; With the Olibanum heating, fry to smoldering, make the surface be pitchy and apparent glossy gloss, taking-up cools, and grinds; Resina garciniae is put into pressure cooker carry out high temperature high pressure process to Resina garciniae and dissolve, take out cooling and grind the end; Venenum Bufonis is beaten carefully, added 2 times Chinese liquor dipping, constantly stirring is the thick paste shape, the dry grinding;
F) component that above steps is obtained, mix homogeneously is dried, pulverizes, is sterilized, and divides the snap fit capsule of packing into.
The present invention is a pure Chinese medicinal preparation, the first component Chinese medicine Herba Hedyotidis Diffusae wherein, Herba Chelidonii, Rhizoma Chuanxiong, Rhizoma Curcumae, Camptotheca acuminata root, Herba Crotalariae sessiliflorae, Semen Coicis have good heat-clearing and toxic substances removing, mass dissipating and swelling eliminating, blood circulation promoting and blood stasis dispelling function, and zoopery proves that they all have antitumaous effect of different nature.The 2nd component Chinese medicine Ganoderma, Radix Pseudostellariae, the Radix Astragali, have good strengthening the body resistance, supplementing QI and nourishing YIN, the hematosis of enriching blood.Clinical experiment and animal experiment prove that this 3 flavor medicine not only has certain antitumaous effect, and can also regulate the immunocompetence of body, improve the resistance against diseases of body comprehensively.The 3rd component Chinese medicine Semen Momordicae frost, Semen Strychni (processed), Olibanum (processed), Resina garciniae (processed), Venenum Bufonis (processed with wine), Rhizoma Kaempferiae, the Pseudobulbus cremastrae seu pleiones consumption is less and certain toxicity is arranged, but they have good detoxifcation pain relieving, the function of hard masses softening and resolving, circulation of qi promoting warming middle-JIAO, and experimental results show that to have the effect of broad-spectrum anticancer analgesic.With this three components drug matching combination; the power of cluster medicine; when cancerous issue is carried out multi-faceted attack; can also improve the resistance against diseases of body and to the identification ability of cancerous tumor cell; fill a part immunologic function of transferring body self, kill cancerous issue, the protection normal structure; thereby embodied eliminating evil preferably and unification that set upright, local and overall unification.Also explanation has only by positive anticancer therapy simultaneously, just can reach good analgesic effect.
Specific implementation method
The anticancer analgesic capsule that the present invention produces, as follows through clinical little test result:
Clinical data: from 1996 to 2004, clinical lab scale was in middle and terminal cancer patient 97 examples, wherein male 54 examples, woman's 43 examples, age of onset 23 years old to 72 years old, course of disease February to 5 year, pulmonary carcinoma 11 examples wherein, colon cancer 4 examples, rectal cancer 7 examples, glioma brain tumour 4 examples, gastric cancer 19 examples, hepatocarcinoma 13 examples, cervical cancer 12 examples, osteocarcinoma 9 examples, nasopharyngeal carcinoma 4 examples, mammary cancer 14 examples.Above-mentioned case is all made a definite diagnosis through fibergastroscope, X-ray sheet, CT, MRI, B ultrasonic.Wherein 21 examples had been done operative treatment, and all the other cases all once tossed about in bed various places and did different western medicines in treatment, and all cancerous pain in various degree all took place case.
Therapeutic Method: provide anticancer analgesic capsule and anticancer analgesic powder (be about to anticancer analgesic Chinese medicine composition of the present invention and add 1/5 Borneolum Syntheticum and 1/5 Mentholum in addition as priming, mixing is ground into powder, is spread in uniform in the medical rubber cream to make) to making a definite diagnosis patient.Usage: oral anticancer analgesic capsule, a 8-12 grain, 3 times on the one, every about 0.4g.To severe pain person, also should be at pain spot or relevant acupuncture points external application anticancer analgesic powder, 1-2 time on the one, the decoction that also will take traditional Chinese medicine is in case of necessity done whole conditioning.
Observational technique: period in a medicine, every day is by the change of inventor's observed and recorded pain degree and the time of pain relief, and by patient with visual simulation scale (VAS method) in " painless----severe pain " horizontal line on the yardstick of pain before and after the recording medicine, use formula then: [numeral before (numeral-treatment back numeral before the treatment)/treatment] * 100, the result judges according to criterion of therapeutical effect with gained.Pain relief part is following 4 kinds: (1) invalid (NR), and relatively preceding with treatment, the pain no change; (2) moderate is alleviated (MR), and pain relief is in 60%; (3) obviously alleviate (AR), pain relief is more than 60%; (4) alleviate (CR) fully, patient does not have pain fully.
The treatment standard: according to the alleviation situation of patient's pain after the medication and the patient time with tumor existence, be decided to be effectively: the pain moderate is alleviated, and patient is with tumor existence at 6 months to 1 year; Produce effects: pain is obviously alleviated, and patient is with tumor existence 1 year to 3 years; Invalid: patient's pain does not have alleviation, and is how dead in 3 months; Clinical cure: patient's total pain relief, the existence of band tumor is more than 3 years.
Therapeutic outcome: invalid 10 people, advanced liver cancer 4 examples, pulmonary carcinoma 5 examples, gastric cancer 1 example had all been done operative treatment, radiation and chemotherapy, when going to here, had found the transfer of cancerous cell many places, and body condition is very poor, can only external application anticancer analgesic medicated powder.Observed through 3-6 days, patient's pain does not have alleviation, and the state of an illness increases the weight of, and haves no alternative but abandoning cure, and is all dead in March, accounts for 10.3%; Effectively: 38 examples, wherein 11 examples had been done operative treatment before the treatment of here, in also being, patient with advanced cancer, behind oral administration anticancer analgesic capsule and the external application anticancer analgesic medicated powder, the pain multipotency reaches moderate in 2 hours ± 30 parts clocks alleviates, and the band tumor was survived 6 months to 1 year, account for 39.2% produce effects: 43 examples, in take medicine and external application anticancer analgesic medicated powder after in 1 hour ± 40 parts clocks pain reach obvious alleviation, the patient is with tumor to survive 1 year to 3 years, accounts for 44.3%; Clinical cure: 6 examples, only need oral anticancer analgesic capsule, the existence of band tumor accounts for 6.2% more than 3 years.Total effective rate is 90%.Here the band tumor of indication existence is meant that cancerous issue does not develop, and does not shift, and body is not produced zest pain, cancerous cell is in a kind of " dormancy " state.
Model case: Mrs Liu, 43 years old, Jiangxia District Fa Si people from town of Wuhan City, Hubei, the peasant suffers from surplus the gastropathy 10 year, is diagnosed as late gastric cancer through the gastroscopy of Jiangxia District First People's Hospital in 1994, and the left clavicle superior gluteal lymph node shifts, and has lost the surgical engine meeting.Arrived the diagnosis and treatment of method nasal mucus difficult miscellaneous diseases out-patient department in 1996 upon somebody's introduction.Health check-up: malnutrition, anemia, face dolorosa, blood pressure 90/60mmHg, pulsation 90 times/part, rule is neat.Abdominal muscle is stiff slightly, the obvious tenderness that taken under the xiphoid-process, no rebound tenderness.Can touch a scleroma, poor mobility on the left clavicle.Tongue is greasy in vain, and matter is pale purple, and indentation is arranged, stringy and thready pulse.Be diagnosed as gastric antrum adenocarcinoma, in late period, differential diagnosis in tcm: gastric abscess, card belongs to qi stagnation and blood stasis type.
Treatment: oral anticancer analgetic capsule, one time 8 (every 0.4 gram), three times on the one.The patient took medicine less than 2 hours, and gastral cavilty portion pain has reached obvious alleviation, pain complete obiteration in 12 hours.Can advance semi-fluid juice after one day, stable disease after the course of treatment of taking medicine was done fibergastroscope once more to 2002, was diagnosed as gastric cancer, and it is unreachable that tumor has been dwindled 1/3 palpation left clavicle superior gluteal lymph node.Take medicine in August, 2004, patient is just painless and whole.
Further illustrate the preparation (is that example illustrates to prepare 2000 grams anticancer analgesic Chinese medicinal composition capsules of the present invention) of Chinese medicine composition of the present invention below again by embodiment:
A) the 1st component is got Herba Hedyotidis Diffusae 900g, Herba Chelidonii 800g, Camptotheca acuminata root 500g, Rhizoma Chuanxiong 700g, Rhizoma Curcumae 500g, Semen Coicis 500g, Herba Crotalariae sessiliflorae 400g, 4300g adds water 30000ml altogether, be heated to boiling, kept 1 hour, and poured out medicine juice, Chinese medicine is decocted 1 time again, pour out medicine juice, the mixing of secondary decocting liquid, stirring, heating are concentrated into 2000ml, add 95% ethanol of 2 times of amounts, left standstill after the stirring 8 hours, remove precipitation, heating makes it remain on 78-79 ℃, fractionates out ethanol, heats further to concentrate, make exsiccant extractum, pulverized 80 mesh sieves.(need to prove each extract in the 1st component by account for this component crude drug dry weight 20%).
B. the 2nd component is got Radix Pseudostellariae 500g, Ganoderma lucidum seu Japonicum 500g, and Radix Astragali 800g, 1800g altogether, the moistening back of ethanol that joins 3000ml75% is airtight, places 3 hours, incites somebody to action the moistening spice gradation after expansible then and packs in the percolator.Open percolator immersion outlet piston,, in percolator, put into 75% ethanol then, cover with gauze above, compress, add a cover and placed 24 hours with surplus air in the expelling tube.Percolate is controlled in the flow velocity of every part of clock 5mL, and constantly replenishes 75% ethanol, and active ingredient is fully leached in medical material.Collect whole leachates, low-press thick shortens extractum into then, and oven dry is pulverized.(need to prove each extract in the 2nd component by account for this component crude drug dry weight 20%).
C. get Pseudobulbus cremastrae seu pleiones 180g, Rhizoma Kaempferiae 200g cleans out, and removes impurity, is ground into fine powder, crosses 80 mesh sieves.(Pseudobulbus cremastrae seu pleiones, Rhizoma Kaempferiae are pressed the dry weight basis of crude drug).
D. (1) takes by weighing Semen Momordicae 250g, shells and gets core, fries to grind the end, with several layers of toilet paper parcels, adds burlap and packs tightly, and squeezing is deoiled, and repeated multiple times is not reproduced oil stain, porphyrize stand-by (the 100g Semen Momordicae can be made into 80g Semen Momordicae frost) to toilet paper;
(2) take by weighing Semen Strychni 100g, add 2 kilograms of sands, fry in pot to Semen Strychni and be brown, remove fur after the cooling, porphyrize is crossed 80 mesh sieves (the 50g Semen Strychni can be made into Semen Strychni (processed) 30g);
(3), in pressure cooker, Resina garciniae is dissolved, cold back porphyrize through high temperature high pressure process with Resina garciniae 10g; (the 10g Resina garciniae can be made into Resina garciniae (processed) 10g)
(4) take by weighing Venenum Bufonis 10g, add Chinese liquor 100ml, constantly stirring is the thick paste shape, dry back porphyrize; (the 10g Venenum Bufonis can be made into Venenum Bufonis (processed with wine) 10g)
(5) claim Olibanum 120g, slow fire is heated to smolders, and makes the surface be pitchy and apparent glossy gloss, takes out and cools grinding.
E. above-mentioned each component is amounted to 2 kilograms of Chinese medicine product uniform mixing, oven dry, porphyrize, sterilization divide " 0 " number gelatin hard capsules of packing into, every about 0.4g.
Need to prove: to those of ordinary skill in the art, can also make some changes or distortion to the present invention under the prerequisite that does not change the principle of the invention, this belongs to protection scope of the present invention equally.
Claims (2)
1, a kind of anticancer analgesic Chinese medicine composition is characterized in that crude drug and hundred parts of ratios of weight thereof of making this Chinese medicine composition active ingredient are: Herba Hedyotidis Diffusae extract 9%, Herba Chelidonii extract 8%, Camptotheca acuminata root extract 5%, Rhizoma Chuanxiong extract 7%, Rhizoma Curcumae extract 5%, Semen Coicis extract 5%, Radix Pseudostellariae extract 5%, Ganoderma lucidum seu Japonicum extract 5%, Herba Crotalariae sessiliflorae extract 4%, Radix Astragali extract 8%; Pseudobulbus cremastrae seu pleiones 9%; Rhizoma Kaempferiae 10%, Semen Momordicae frost 10%, Semen Strychni (processed) 3%, Resina garciniae (processed) 0.5%, Venenum Bufonis (processed with wine) 0.50%, Olibanum 6%.
2, the method for preparation anticancer analgesic Chinese medicinal composition capsules as claimed in claim 1 agent is:
A) take by weighing above-mentioned Chinese medicine in proportion, and above-mentioned Chinese medicine is divided into three components, the 1st component Chinese medicine is: Herba Hedyotidis Diffusae, Herba Chelidonii, Rhizoma Chuanxiong, Rhizoma Curcumae, Semen Coicis, Camptotheca acuminata root, Herba Crotalariae sessiliflorae, and the crude drug of each Chinese medicine in described the 1st component: 5 times by extracts from crude drugs weight take by weighing; The 2nd component Chinese medicine is: Radix Pseudostellariae, Ganoderma lucidum seu Japonicum, the Radix Astragali, and the crude drug of each Chinese medicine in described the 2nd component: 5 times by extracts from crude drugs weight take by weighing; The 3rd component Chinese medicine is: Pseudobulbus cremastrae seu pleiones, Rhizoma Kaempferiae, Semen Momordicae, Semen Strychni, Resina garciniae, Venenum Bufonis, Olibanum; Pseudobulbus cremastrae seu pleiones, Rhizoma Kaempferiae, Olibanum took by weighing by 1: 1 in described the 3rd component; Described Semen Momordicae: the Semen Momordicae frost took by weighing by 10: 8; Described Semen Strychni: Semen Strychni (processed) took by weighing by 10: 6; Described Resina garciniae (processed), Venenum Bufonis (processed with wine), Olibanum all take by weighing in 1: 1 ratio;
B) the 1st component Chinese medicine Herba Hedyotidis Diffusae, Herba Chelidonii, Rhizoma Chuanxiong, Rhizoma Curcumae, Semen Coicis, Camptotheca acuminata root, Herba Crotalariae sessiliflorae are mixed, add total amount 5-8 water doubly, be heated to boiling, kept 1 hour, and poured out medicinal liquid, again Chinese medicine is decocted once again, pour out medicinal liquid, mix stirring with the 1st decocting liquid, it is concentrated to heat, 95% ethanol that adds 2 times of amounts after cooling mixes and stirs, and leaves standstill and removes precipitation, heating makes it remain on 78-79 ℃, fractionates out ethanol, makes extractum, after the drying, pulverized, crossed 80 mesh sieves;
C) Radix Pseudostellariae, Ganoderma lucidum seu Japonicum, the Radix Astragali are extracted with percolation: earlier Chinese medicine is broken into coarse powder, airtight with 75% the moistening back of ethanol of equivalent, placed 3 hours, then with in the inferior percolator of packing into of the spice part after the moistening expansion; Open percolator immersion outlet piston,, in percolator, put into 75% ethanol then, cover with gauze above, compress, add a cover and placed 24 hours with surplus air in the expelling tube; Percolate is controlled in the flow velocity of every part of clock 5mL, and constantly replenishes 75% ethanol, a part leaching is filled in active ingredient in medical material; Collect whole leachates, low-press thick shortens extractum into then, and oven dry is pulverized;
D) Pseudobulbus cremastrae seu pleiones, Rhizoma Kaempferiae are cleaned out, removal of contamination is ground into smalls, crosses 80 mesh sieves;
E) Semen Momordicae is made the Semen Momordicae frost: get clean Semen Momordicae and shell and get core, fry and grind the end, with several layers of toilet paper parcels, add burlap and pack tightly, squeezing is deoiled, repeated multiple times; With the Olibanum heating, fry to smoldering, make the surface be pitchy and apparent glossy gloss, taking-up cools, and grinds; Resina garciniae is put into pressure cooker carry out high temperature high pressure process to Resina garciniae and dissolve, take out cooling and grind the end; Venenum Bufonis is beaten carefully, added 2 times Chinese liquor dipping, constantly stirring is the thick paste shape, the dry grinding;
F) component that above steps is obtained, mix homogeneously is dried, pulverizes, is sterilized, part snap fit capsule of packing into.
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