CN103142893B - Traditional Chinese medicinal composition for nursing and treating tristimania - Google Patents
Traditional Chinese medicinal composition for nursing and treating tristimania Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal composition for nursing and treating tristimania. The traditional Chinese medicinal composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 8-15 parts of poria cocos, 8-15 parts of ligusticum chuanxiong, 8-15 parts of polygala tenuifolia, 8-15 parts of radix ophiopogonis, 25-35 parts of fructus aurantii immaturus, 25-35 parts of lilium davidii duchartre, 25-35 parts of semen coicis, 25-35 parts of fructus tritici levis, 10-16 parts of rhizoma acori graminei and 4-8 parts of fructus schizandrae. The traditional Chinese medicinal composition provided by the invention is remarkable in efficacy, and meanwhile, the side-effect is obviously reduced, and the administration dependency of a patient is high.
Description
Technical field
The invention belongs to Chinese medicine technical field, in particular to a kind of Chinese medicine composition for the treatment of anxiety neurosis.
Background technology
Anxiety neurosis (anxiety) is a kind of taking anxiety as main neurosis, is mainly divided into panic disorder and generalized anxiety disorder.It is taking a kind of overstrain that lacks clear and definite object and particular content, on tenterhooks, frightened and restless or ictal in terror as the dysthymic disorder of principal character, with significant autonomic nervous dysfunction's symptom, muscular tone and mobility's uneasiness.Patient's endurable cannot be freed again, and agonizes very much.At present, clinical treatment is mainly taking western medicine as main, but its untoward reaction is obvious, and patient is difficult to accept more.When clinical treatment, first-selected Benzodiazepine medicine or antidepressants, because Benzodiazepine medicine has addiction, drug resistance and withdrawal symptom, clinically often select existing antidepressant to have again sedation and anti-anxiety medicine doxepin treatment.But doxepin belongs to tricyclic antidepressant, often there are excessive calmness and anticholinergic effect, performance xerostomia, constipation, blurred vision, there is dysuria in severe one, often affects patient compliance.
The traditional Chinese medical science is just attached great importance to the pathogenic situation of feelings will from ancient times, and anxiety neurosis Chinese medical discrimination belongs to seven emotions and causes a disease and cause depression of liver-QI, due to lack of preservation of spirit.The Chinese pathology factor that studies have found that anxiety neurosis is the stagnation of QI, and fire is contained, blood deficiency; In cure the desease position for liver, the heart; TCM Syndrome Type is stagnated QI transforming into fire, and clinical mainly with soothing the liver pathogenic fire purging, nourishing blood to tranquillize the mind method is treated this disease.
Summary of the invention
The object of the invention is to by prescription again after conventional medicament pharmacology is studied, the Chinese medicine composition of the anxiety disease that a kind of good effect, instant effect, side effect are little is provided.
The object of the present invention is achieved like this:
The Chinese medicine composition of a kind of nursing for treating anxiety neurosis of the present invention, is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Poria 8-15 part, Rhizoma Chuanxiong 8-15 part, Radix Polygalae 8-15 part, Radix Ophiopogonis 8-15 part, Fructus Aurantii Immaturus 25-35 part, Bulbus Lilii 25-35 part, Semen Coicis 25-35 part, Fructus Tritici Levis 25-35 part, Rhizoma Acori Graminei 10-16 part, Fructus Schisandrae Chinensis 4-8 part.
The Chinese medicine composition of above-mentioned nursing for treating anxiety neurosis, is preferably prepared from by the traditional Chinese medicinal material raw materials of following weight portion: 12 parts, Poria, 12 parts of Rhizoma Chuanxiongs, 12 parts of Radix Polygalaes, 12 parts of Radix Ophiopogonis, 30 parts of Fructus Aurantii Immaturuss, 30 parts of Bulbus Lilii, 30 parts of Semen Coiciss, 30 parts of Fructus Tritici Levis, 13 parts of Rhizoma Acori Graminei, 6 parts of Fructus Schisandrae Chinensis.
Preferably, the Chinese medicine composition of above-mentioned nursing for treating anxiety neurosis is oral formulations.
The Chinese medicine composition of more further preferably, above-mentioned nursing for treating anxiety neurosis is granule.
According to Chinese medicine Historical Data Data About, the pharmacologically active of said medicine material is as follows:
Poria: there is diuretic, effect of eliminating dampness by diuresis diuresis.Cure mainly dysuria; Edema distension; Phlegm retention cough with dyspnea; Vomiting; Insufficiency of the spleen lack of appetite; Have loose bowels; Palpitation and restlessness; Insomnia forgetfulness; Seminal emission nebulousurine.Select the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.
Rhizoma Chuanxiong: blood-activating and qi-promoting, wind-expelling pain-stopping.Be used for pacifying nerve, positive wind syndrome of head headache, lump in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Select the rhizome of samphire Rhizoma Chuanxiong.
Radix Polygalae: the function of there is the Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, subsiding a swelling, the insomnia and dreamful sleep causing for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.Select the dry root of milk wort Radix Polygalae Polygala tenuifolia Willd. and ovum leaf Radix Polygalae P.sibirica L..
Radix Ophiopogonis: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.Be selected from Liliaceae Ophiopogon plant Ophiopogon Radix Ophiopogonis Japonicus(Thunb.) dried root of Ker-Gawl..
Fructus Aurantii Immaturus: stop in stagnant; Feeling of fullness distending pain; Constipation; Heavy after dysentery; Blocked-up chest; Gastroptosis; Uterine prolapse; Proctoptosis.Select rutaceae Citrus aurantium Linn. Citrus aurantium L. and variety thereof or Fructus Citri sinensis Citrus sinensis (L.) Osbeck dry young fruit.
Bulbus Lilii: select Bulbus Lilii bulb to be used as medicine.Nourishing the lung to arrest cough, clearing away heart-fire for tranquillization, diuresis.For diseases such as xeropulmonary cough, pulmonary tuberculosis hemoptysis, chronic bronchitis, fidgets due to deficiency palpitation with fear, hot the remnant pathogenic heat being not dispelled, staring spells, carbuncle.
Semen Coicis: spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal.Semen Coicis can be used for treating edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen.
Fructus Tritici Levis: be shrivelled frivolous Semen Tritici aestivi, water is washed in a pan the person of floating.Except deficiency-heat; Hidroschesis.Main only fever due to yin deficiency; Night sweat; Spontaneous perspiration.
Rhizoma Acori Graminei: removing dampness appetizing, the eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.Not hungry for gastral cavity painful abdominal mass, mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness.Regulate the flow of vital energy, invigorate blood circulation, loose wind, dries.Control epilepsy, syncope due to accumulation of phlegm, calentura coma, forgetful, deafness with qi stagnation, ambition unhappiness, stomachache, stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, traumatic injury.Derive from the rhizome of acorus gramineus araceae plant.
Fructus Schisandrae Chinensis: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, the deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.
The preparation method that above-mentioned each Chinese crude drug is prepared into compound granular agent of the present invention, comprises the steps:
Take the Poria 8-15 part cleaning up by recipe quantity, Rhizoma Chuanxiong 8-15 part, Radix Polygalae 8-15 part, Radix Ophiopogonis 8-15 part, Fructus Aurantii Immaturus 25-35 part, Bulbus Lilii 25-35 part, Semen Coicis 25-35 part, Fructus Tritici Levis 25-35 part, Rhizoma Acori Graminei 10-16 part and Fructus Schisandrae Chinensis 4-8 part, merge, decoct with water twice, add water for the first time as 10 times of amounts of medical material weight, decoct 1.5h, add water for the second time as 8 times of amounts of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, the extractum that while being evaporated to 65 DEG C at 60-70 DEG C, relative density is 1.15, adding 95% (v/v) ethanol makes to reach 75% (v/v) containing alcohol amount, stir, leave standstill 24 hours, filter, filtrate is at 0.07MPa, when under 65 DEG C of conditions, concentrating under reduced pressure becomes to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, (condition is that inlet temperature is 100 DEG C by dry concentrated solution spraying, leaving air temp is 80 DEG C, temperature of charge is 80 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), pulverized 80 mesh sieves, obtain clear paste powder; According to clear paste powder: the weight ratio of dextrin 1:1～3 takes clear paste powder, dextrin and appropriate 55% ethanol, wherein 55% ethanol refers to that volumetric concentration is 55% ethanol water, clear paste powder and dextrin are dropped in trough type mixing machine, stir 20 minutes, slowly add while stirring 55% ethanol, to making soft material, with 12 order stainless steel sifts granulations, 65～75 DEG C are dried 2 hours, take out, and cool and obtain described granule.Chinese medicine composition curative effect of the present invention is better than Western medicine, and side reaction simultaneously obviously reduces, and therefore the interdependence of patient's medication is high.
Detailed description of the invention
Be below specific embodiments of the invention, technical scheme of the present invention is done to further description, but protection scope of the present invention is not limited to these embodiment.Every do not deviate from the change of the present invention design or be equal to substitute include within protection scope of the present invention.
Embodiment 1
Crude drug prescription: 120 grams, Poria, 120 grams of Rhizoma Chuanxiongs, 120 grams of Radix Polygalaes, 120 grams of Radix Ophiopogonis, 300 grams of Fructus Aurantii Immaturuss, 300 grams of Bulbus Lilii, 300 grams of Semen Coiciss, 300 grams of Fructus Tritici Levis, 130 grams of Rhizoma Acori Graminei, 60 grams of Fructus Schisandrae Chinensis.
Preparation technology: take the above-mentioned Chinese crude drug cleaning up by recipe quantity, merge, decoct with water twice, add water for the first time as 10 times of amounts of medical material weight, decoct 1.5h, add water for the second time as 8 times of amounts of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, the extractum that while being evaporated to 65 DEG C at 60-70 DEG C, relative density is 1.15, adding 95% (v/v) ethanol makes to reach 75% (v/v) containing alcohol amount, stir, leave standstill 24 hours, filter, filtrate is at 0.07MPa, when under 65 DEG C of conditions, concentrating under reduced pressure becomes to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, (condition is that inlet temperature is 100 DEG C by dry concentrated solution spraying, leaving air temp is 80 DEG C, temperature of charge is 80 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), pulverized 80 mesh sieves, obtain clear paste powder; According to clear paste powder: the weight ratio of dextrin 1:2.5 takes clear paste powder, dextrin and appropriate 55% ethanol, wherein 55% ethanol refers to that volumetric concentration is 55% ethanol water, clear paste powder and dextrin are dropped in trough type mixing machine, stir 20 minutes, slowly add while stirring 55% ethanol, to making soft material, granulate with 12 order stainless steel sifts, 65～75 DEG C are dried 2 hours, take out, cool and obtain described granule, by every bag of 15g packaging.
Embodiment 2
Crude drug prescription: 150 grams, Poria, 80 grams of Rhizoma Chuanxiongs, 100 grams of Radix Polygalaes, 150 grams of Radix Ophiopogonis, 350 grams of Fructus Aurantii Immaturuss, 350 grams of Bulbus Lilii, 300 grams of Semen Coiciss, 250 grams of Fructus Tritici Levis, 100 grams of Rhizoma Acori Graminei, 80 grams of Fructus Schisandrae Chinensis.
Preparation technology: take the above-mentioned Chinese crude drug cleaning up by recipe quantity, merge, decoct with water twice, add water for the first time as 10 times of amounts of medical material weight, decoct 1.5h, add water for the second time as 8 times of amounts of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, the extractum that while being evaporated to 65 DEG C at 60-70 DEG C, relative density is 1.15, adding 95% (v/v) ethanol makes to reach 75% (v/v) containing alcohol amount, stir, leave standstill 24 hours, filter, filtrate is at 0.07MPa, when under 65 DEG C of conditions, concentrating under reduced pressure becomes to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, (condition is that inlet temperature is 100 DEG C by dry concentrated solution spraying, leaving air temp is 80 DEG C, temperature of charge is 80 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), pulverized 80 mesh sieves, obtain clear paste powder; According to clear paste powder: the weight ratio of dextrin 1:3 takes clear paste powder, dextrin and appropriate 55% ethanol, wherein 55% ethanol refers to that volumetric concentration is 55% ethanol water, clear paste powder and dextrin are dropped in trough type mixing machine, stir 20 minutes, slowly add while stirring 55% ethanol, to making soft material, granulate with 12 order stainless steel sifts, 65～75 DEG C are dried 2 hours, take out, cool and obtain described granule, by every bag of 15g packaging.
Embodiment 3
Crude drug prescription: 80 grams, Poria, 150 grams of Rhizoma Chuanxiongs, 150 grams of Radix Polygalaes, 80 grams of Radix Ophiopogonis, 250 grams of Fructus Aurantii Immaturuss, 250 grams of Bulbus Lilii, 350 grams of Semen Coiciss, 350 grams of Fructus Tritici Levis, 160 grams of Rhizoma Acori Graminei, 80 grams of Fructus Schisandrae Chinensis.
Preparation technology: take the above-mentioned Chinese crude drug cleaning up by recipe quantity, merge, decoct with water twice, add water for the first time as 10 times of amounts of medical material weight, decoct 1.5h, add water for the second time as 8 times of amounts of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, the extractum that while being evaporated to 65 DEG C at 60-70 DEG C, relative density is 1.15, adding 95% (v/v) ethanol makes to reach 75% (v/v) containing alcohol amount, stir, leave standstill 24 hours, filter, filtrate is at 0.07MPa, when under 65 DEG C of conditions, concentrating under reduced pressure becomes to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, (condition is that inlet temperature is 100 DEG C by dry concentrated solution spraying, leaving air temp is 80 DEG C, temperature of charge is 80 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), pulverized 80 mesh sieves, obtain clear paste powder; According to clear paste powder: the weight ratio of dextrin 1:3 takes clear paste powder, dextrin and appropriate 55% ethanol, wherein 55% ethanol refers to that volumetric concentration is 55% ethanol water, clear paste powder and dextrin are dropped in trough type mixing machine, stir 20 minutes, slowly add while stirring 55% ethanol, to making soft material, granulate with 12 order stainless steel sifts, 65～75 DEG C are dried 2 hours, take out, cool and obtain described granule, by every bag of 15g packaging.
The experimental study of embodiment 4 Chinese medicine granules treatment anxiety neurosis
59 routine anxiety patients, meet the diagnostic criteria of the 3rd edition (CCMD-3) generalized anxiety disorder of Chinese Spirit Obstacles classification and diagnostic criteria, and Hamilton anxiety scale (HAMA) divides >=14 points; Get rid of physical disease, schizophrenia, depression.Be divided at random Chinese drug-treated group (32 example) and matched group (27 example).Epidemiological Analysis by statistics, sex between two groups, age there was no significant difference (
p> is O.05), there is comparability.
Matched group patient takes doxepin, starts 25mg one time according to doctor's advice, 2-3 time on the one, is increased to gradually a daily amount 100-250mg, continuous use 6 weeks later.The Chinese drug-treated group patient 1 bag/d of Chinese medicine granules (being prepared from according to the prescription of embodiment 1 and technique) that takes after mixing it with water, continuous use 6 weeks.Meanwhile, two groups of patients all adopt comprehensive psychotherapy, comprising: 1. build up mutual trust: first set up good doctor-patient relationship with patient, obtain patient's trust; 2. health propaganda and education: explain targetedly the ABC of anxiety neurosis, analyze patient's character trait, find out the psychosocial factor of patient's morbidity; 3. cognitive treatment: by talking timely discovery patient's bad coping style and unreasonable belief, help patient be familiar with wrong cognition and corrected, and point out the relation of asking of these erroneous cognitions and anxiety, re-establish correct cognitive system.1～2 time/week, 50～60 min/ time; 4. relaxation training: take to listen to the music or electronics biofeedback carries out relaxation training, repeat, reach the object that whole body loosens, 3 times/week, 30 min/ time; 5. patient's treatment of helping each other: organize anxiety patient to exchange, mutually pour out the impression in therapeutic process, allow patient see hope with it from the good patient of therapeutic effect, the positive partner treatment of excitation patient.1 time weekly, 30～60min/ time; 6. family and the treatment of social support sexual psychology: family numbers of patients and colleague are carried out to the explanation of anxiety neurosis relevant knowledge, instruct them to be concerned about and help patient, support and confidence to patient.1 time/week, 30～60min/ time.
Adopt level Four curative effect and HAMA (Hamilton Anxiety Scale) scoring to carry out efficacy evaluation.Subtract point rate >75% for recovery from illness, 50%-74% is marked improvement, and 25%-49% is for progressive, and <25% is invalid.Calculate obvious effective rate with healing+marked improvement; Calculate total effective rate with healing+marked improvement+progress.The results are shown in Table 1.
Can find out from the result of the test of table 1, Chinese drug-treated group obvious effective rate and total effective rate are all higher than western medicine group.
Table 1 liang group curative effect comparison [example, (%)]
In addition, in experimentation, find, Chinese drug-treated group untoward reaction 4 examples (12.5%), main manifestations dizziness, nauseating, anorexia, its degree is lighter, after one week, fades away.Matched group untoward reaction l5 example (55.6%), showing drowsiness, headache, dizzy, weak, xerostomia, blurred vision, tachycardia, dysuria, anorexia, particularly drowsiness, excessive calmness, blurred vision, dysuria affects larger on patient.
Claims (4)
1. a Chinese medicine composition for the treatment of anxiety neurosis, is characterized in that: the traditional Chinese medicinal material raw materials by following weight portion is prepared from: Poria 8-15 part, Rhizoma Chuanxiong 8-15 part, Radix Polygalae 8-15 part, Radix Ophiopogonis 8-15 part, Fructus Aurantii Immaturus 25-35 part, Bulbus Lilii 25-35 part, Semen Coicis 25-35 part, Fructus Tritici Levis 25-35 part, Rhizoma Acori Graminei 10-16 part, Fructus Schisandrae Chinensis 4-8 part.
2. the Chinese medicine composition for the treatment of anxiety neurosis according to claim 1, is characterized in that: the traditional Chinese medicinal material raw materials by following weight portion is prepared from: 12 parts, Poria, 12 parts of Rhizoma Chuanxiongs, 12 parts of Radix Polygalaes, 12 parts of Radix Ophiopogonis, 30 parts of Fructus Aurantii Immaturuss, 30 parts of Bulbus Lilii, 30 parts of Semen Coiciss, 30 parts of Fructus Tritici Levis, 13 parts of Rhizoma Acori Graminei, 6 parts of Fructus Schisandrae Chinensis.
3. the Chinese medicine composition for the treatment of anxiety neurosis according to claim 1 and 2, is characterized in that: described Chinese medicine composition is oral formulations.
4. the Chinese medicine composition for the treatment of anxiety neurosis according to claim 1 and 2, is characterized in that: described Chinese medicine composition is granule.
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