CN101804175A - Anti-cancer Chinese medicinal powder and preparation method thereof - Google Patents
Anti-cancer Chinese medicinal powder and preparation method thereof Download PDFInfo
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Abstract
The invention relates to anti-cancer Chinese medicinal powder and a preparation method thereof, belonging to the technical field of medicament. The Chinese medicinal powder comprises the following medicinal materials: venin microcrystalline cellulose clathrate compound, green tea CO2 supercritical extract, gynostemma pentaphylla CO2 supercritical extract, epimedium CO2 supercritical extract, shizandra berry CO2 supercritical extract, lesser galangal rhizome CO2 supercritical extract, ganoderma lucidum fine powder, broken ganoderma spore powder, zedoary fine powder, sculellaria barbata fine powder, radix zanthoxyli fine powder, celandine fine powder, semen coicis fine powder, Chinese date fine powder, isatis root fine powder, prepared rehmannia rhizome fine powder and astragalus mongholicus fine powder, wherein the prepared medicinal powdered preparations are mixed uniformly and encapsulated according to medicament formula. According to weight of a patient body, the Chinese medicinal powder is mixed with warm water 30 minutes before meals, and is taken 3.5 to 4.5 grams per time. The Chinese medicinal powder is forbidden to the patient who is subjected to visceral major surgeries in one month. The Chinese medicinal powder can effectively treat solid tumors and mainly treat lung cancer, and has good curative effect to solid tumor of a digestive system.
Description
Technical field
The present invention relates to a kind of Chinese medicine medicine for preventing powder and preparation method thereof, belong to medical technical field.
Background technology
Cancer is a kind of disease that heals than refractory in the middle of the contemporary mankind, and the annual number of the infected of China is more than 2,300,000, and death toll reaches more than 1,700,000.The medicine of present treatment cancer and auxiliary treating method have a variety of, but effect is not ideal.
The inventor has declared " a kind of Chinese medicine medicine for preventing powder and preparation method thereof " (01123530.6) July 30 calendar year 2001, and obtain the authorization on January 12nd, 2005 (CN1183928C).In the clinical practice in nearly ten years thereafter, to sum up and developed new prescription, its prescription composition, processing technique, clinical efficacy have had major progress than the medicine of former patent, and therapeutic effect is better.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine medicine for preventing powder and preparation method thereof, this Chinese powder medicine can effectively be treated solid tumor, based on pulmonary carcinoma, the solid tumor of digestive system is also had better curative effect.Proof is because scientific formulation, technology advanced person in practice, non-evident effect, but and combination with radiotherapeutic, chemotherapeutic efficacy better.
A kind of Chinese medicine medicine for preventing powder of the present invention, form by following each components by weight percent proportioning:
Snake venom microcrystalline Cellulose clathrate 5-7g
Green tea CO
2Supercritical extract 70-90g
Herb Gynostemmae Pentaphylli CO
2Supercritical extract 70-90g
Herba Epimedii CO
2Supercritical extract 70-90g
Fructus Schisandrae Chinensis CO
2Supercritical extract 10-30g
Rhizoma Alpiniae Officinarum CO
2Supercritical extract 10-30g
The smart powder 110-130g of red ganoderma Sporoderm-broken Ganoderma Lucidum Spore powder 12-15g
The smart powder 70-90g of the smart powder 30-50g of Rhizoma Curcumae Herba Scutellariae Barbatae
The smart powder 10-30g of the smart powder 10-30g of Radix Zanthoxyli Herba Chelidonii
The smart powder 100-130g of essence of Job's tears powder 70-90g Fructus Jujubae
The smart powder 63-90g of the smart powder 30-50g of Radix Isatidis Radix Rehmanniae Preparata
Radix Astragali essenc powder 103-115g
The preparation method of a kind of Chinese medicine medicine for preventing powder of the present invention:
A. the preparation of snake venom microcrystalline Cellulose clathrate: get cobra venom 3g, agkistrodon halyx pallas venom 3g adds enteric solubility microcrystalline Cellulose 122g, grinds behind mix homogeneously and makes clathrate.
B. the preparation of green tea, Herb Gynostemmae Pentaphylli, Herba Epimedii, Fructus Schisandrae Chinensis, Rhizoma Alpiniae Officinarum: get green tea, Herb Gynostemmae Pentaphylli, Herba Epimedii, Fructus Schisandrae Chinensis, Rhizoma Alpiniae Officinarum and carry out CO respectively
2The extraction of supercritical technological method for processing obtains the finished product powder after drying.Every 100Kg crude drug extraction 2.5Kg finished product powder.
C. the preparation of Sporoderm-broken Ganoderma Lucidum Spore powder: Ganoderma spore powder is smashed the Ganoderma spore powder wall after machining, and sporoderm-broken rate should be more than 90%.
D. the preparation of red ganoderma, the Radix Astragali, Rhizoma Curcumae, Herba Scutellariae Barbatae, Radix Zanthoxyli, Herba Chelidonii, Radix Isatidis, Radix Rehmanniae Preparata, Fructus Jujubae, essence of Job's tears powder: get red ganoderma, the Radix Astragali, Rhizoma Curcumae, Herba Scutellariae Barbatae, Radix Zanthoxyli, Herba Chelidonii, Radix Isatidis, Radix Rehmanniae Preparata, Fructus Jujubae, Semen Coicis, carry out the High Temperature High Pressure extraction respectively.Every kind of medicine adds the water of ten times of weight at every turn, and temperature 90-100 ℃, two atmospheric pressure, three extraction ingredients: two hours for the first time, one and a half hours for the second time, one hour for the third time.Extracting solution is taken out in each back of extracting, and three extracting solution are mixed, and makes smart powder after drying.Every 100kg crude drug is made smart powder 2.5kg.
E. medicament preparation: the medical material powder that above a-d is prepared respectively, by the components by weight percent proportioning mix homogeneously encapsulation of aforementioned drug prescription, standby.
The side separates
One. the present invention is under the theoretical direction of combined traditional Chinese medicine, according to the principles of formulating prescriptions of herbal function family of molecule, disposes according to the treatment cancer five target spots theory of this Chinese medicine inventor-combination of Chinese and Western medicine chief physician establishment.
Five action target spots of its treatment cancer are respectively:
First target spot: act on the T.B lymphocyte, enhancing human body immunity power
If this organizes drug main: red ganoderma, the Radix Astragali, Herba Epimedii, Herba Scutellariae Barbatae etc.Its effect is to promote the T lymphopoiesis, transforms, and promotes bone-marrow-derived lymphocyte to strengthen and generates antibody function.
Second target spot: act on cell membrane, nucleus direct killing or cause apoptosis of tumor cells.Main medicine is the film toxin protein of snake venom such as snake venom, and the dissolved cancer cell film causes cytolysis; Or act on nucleus, and suppress the synthetic nuclear that causes of DNA and solidify, cause apoptosis of tumor cells.
The 3rd target spot: suppress telomerase, topological enzyme:
The cancerous cell telomerase, topological enzyme is active, causes cancerous cell sharply to be bred, and red ganoderma and spore powder with crushed sporoderm can significantly suppress telomerase activation; Green tea, Herba Epimedii more have the telomerase activation of inhibition function; The Herba Chelidonii alkaloid that natural nitidine that Radix Zanthoxyli is contained and Herba Chelidonii are contained all can be caught the topological enzyme complex, suppresses its activity, the anticancer growth.
The 4th target spot: the vasoactive endothelial cell growth factor (ECGF), suppress the cancerous tissue angiogenesis, cancerous cell hungry to death.Herb Gynostemmae Pentaphylli contains a large amount of elemental selenium.It can suppress the tumor tissues angiogenesis.Make tumor tissues lack the hemotrophic nutrition provisioning and apoptosis.
The 5th target spot: act on the P-8P running albumen on the cancer cell membrane, overcome tumor cell drug resistance.Main medicine is the contained schisandrin B of Fructus Schisandrae Chinensis, and it can suppress memebrane protein P-8P activity, thereby increases the cancer therapy drug activity in the cancerous cell.Thereby the drug resistance that has overcome tumor cell also can increase the curative effect of radiotherapy chemotherapy medicine.
Two. the present invention meets the basic theories that traditional Chinese medicine is controlled " tumor " medicine: strengthening the body resistance, heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving.Selected medicine can be divided into principal agent, adjuvant drug, messenger drug three classes.
1. principal agent: strengthening the body resistance is main
Red ganoderma: sweet and slightly bitter taste, property is flat, invigorating primordial QI, nourishing blood to tranquillize the mind.
Herba Epimedii: hot, sweet, warm, return the Liver and kidney warp, kidney-replenishing, wind-damp dispelling.
The Radix Astragali: sweet, warm, return the liver spleen channel, invigorating QI to consolidate the body surface resistance.
Herb Gynostemmae Pentaphylli: bitter in the mouth, cold in nature, invigorating primordial QI, the controlling nocturnal emission with astringent drugs that promotes the production of body fluid, spleen-benefiting mind-tranquilizing.
2. adjuvant drug: eliminating evil is main
Naja, Agkistrodon halys, all warm in nature, sweet, poisonous, dispelling wind and removing obstruction in the collateral; Its snake venom then has more promoting blood circulation to remove obstruction in the collateral, eliminating evil effect.
Rhizoma Curcumae: acrid in the mouth, warm in nature, return the liver spleen channel, clots absorbing removing blood stasis, repercussive pain relieving.
Herba Scutellariae Barbatae: sweet in the mouth, light, slightly warm in nature.Expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation.
3. messenger drug
Fructus Schisandrae Chinensis: sour in the mouth, warm in nature, return lung heart channel.Mainly curing cancer of lung of the present invention, the Fructus Schisandrae Chinensis priming is gone into lung meridian, guarantees its curative effect.
Radix Isatidis: bitter in the mouth, cold in nature, heat-clearing and toxic substances removing, liver heat removing and making eye bright, priming goes into Liver Channel person.
Three. the present invention fills a prescription rationally, meets the anticancer theory of Clement, promptly suppresses three basic skills of tumor:
1. anticancer DNA is synthetic: make cancerous cell be in resting state, can not grow.Use snake venom among the present invention, just possess the synthetic effect of anticancer DNA.And contained organic germanium in the red ganoderma is very strong oxidant, also goes to have played the synthetic effect of anticancer DNA.
2. cut off the energy supply of cancerous cell, make its energy drain and apoptosis.The Radix Astragali among the present invention all contains abundant elemental selenium-the Western countries and is known as anticancer king in the Herb Gynostemmae Pentaphylli, it suppresses tumor tissues blood vessel liter gives birth to, thereby has cut off the hemotrophic nutrition supply, causes death of neoplastic cells.
3. destroy the cell telomerase, cancerous cell can't be divided.Green tea among the present invention contains tea polyphenols, and Herba Epimedii, all is inhibitor of telomerase.
A kind of Chinese medicine medicine for preventing powder of the present invention, once in the extensive use of more than 10 tame medical research cooperation unit, accumulative total was treated various malignant tumor 1700 many cases, and curative effect is comparatively satisfied.Hepatocarcinoma 245 examples wherein, gastric cancer 160 examples, esophageal carcinoma 83 examples, intestinal cancer 76 examples, pulmonary carcinoma 157 examples.
Criterion of therapeutical effect:
Alleviate fully (CR):, confirm that all tumor parameters disappear by being no less than for 4 weeks each issue and the separated second phase observes.
Part is alleviated (PR): by being no less than for 4 weeks each issue and the separated second phase observes, confirm all tumor measured parameters dwindle 50% or more than, and do not have clinical new focus and occur.
Tumor is stablized constant (NC): one or more measurable tumor focus do not narrow down to 50% or be not increased to 25%.
Progress or worsen (PD): the measured value of tumor increases and surpasses 25% or new focus occurs.
Effective percentage=alleviation+part is alleviated+stablizes constant fully
Therapeutic evaluation: the courses of treatment 12 week＜three month
After this organized 87 routine patient treatments, alleviation person's 6 examples accounted for 6.89% fully; Part is alleviated 26 examples, accounts for 29.89%; Tumor is stablized constant 30 examples, accounts for 34.48%; The progress or worsen 25 examples, account for 28.74%, effective percentage reaches 71.26%.
Instructions of taking:
A kind of Chinese medicine medicine for preventing powder of the present invention is looked the body weight of its individual patients, each 3.5-4.5g, and 30 minutes ante cibum, warm water was taken after mixing it with water.
Forbid person within internal organs major operation one month.
The specific embodiment
Embodiment 1:
A kind of Chinese medicine medicine for preventing powder of the present invention, form by following each components by weight percent proportioning:
Snake venom crystallite clathrate 5g, green tea extract 70g, Herb Gynostemmae Pentaphylli extract 90g, Herba Epimedii extract 70g, red ganoderma extract 110g, Sporoderm-broken Ganoderma Lucidum Spore powder 12g, Rhizoma Curcumae extract 30g, Herba Scutellariae Barbatae extract 90g, Fructus Schisandrae Chinensis extract 10g, Radix Zanthoxyli extract 30kg, Herba Chelidonii extract 10g, Semen Coicis extract 70g, Fructus Jujubae extract 130g, Rhizoma Alpiniae Officinarum extract 30g, Radix Isatidis extract 50g, Radix Rehmanniae Preparata extract 90g, Radix Astragali extract 103g.
Embodiment 2
Snake venom crystallite clathrate 7g, green tea extract 90g, Herb Gynostemmae Pentaphylli extract 70g, Herba Epimedii extract 90g, red ganoderma extract 130g, Sporoderm-broken Ganoderma Lucidum Spore powder 15g, Rhizoma Curcumae extract 50g, Herba Scutellariae Barbatae extract 70g, Fructus Schisandrae Chinensis extract 30g, Radix Zanthoxyli extract 10g, Herba Chelidonii extract 30g, Semen Coicis extract 90g, Fructus Jujubae extract 100g, Rhizoma Alpiniae Officinarum extract 10g, Radix Isatidis extract 30g, Radix Rehmanniae Preparata extract 63g, Radix Astragali extract 115g.
Embodiment 3
Snake venom crystallite clathrate 6g, green tea extract 80g, Herb Gynostemmae Pentaphylli extract 80g, Herba Epimedii extract 80g, red ganoderma extract 120g, Sporoderm-broken Ganoderma Lucidum Spore powder 13g, Rhizoma Curcumae extract 40g, Herba Scutellariae Barbatae extract 80g, Fructus Schisandrae Chinensis extract 25g, Radix Zanthoxyli extract 20g, Herba Chelidonii extract 30g, Semen Coicis extract 80g, Fructus Jujubae extract 100g, Rhizoma Alpiniae Officinarum extract 20g, Radix Isatidis extract 40g, Radix Rehmanniae Preparata extract 80g, Radix Astragali extract 106g.
Embodiment 4
The preparation method of a kind of Chinese medicine medicine for preventing powder of the present invention: the step of the preparation method of each the medicine raw material among the embodiment 1-3:
A. the preparation of snake venom microcrystalline Cellulose clathrate: get cobra venom 3g, agkistrodon halyx pallas venom 3g adds enteric solubility microcrystalline Cellulose 122g, grinds behind mix homogeneously and makes clathrate.
B. the preparation of green tea, Herb Gynostemmae Pentaphylli, Herba Epimedii, Fructus Schisandrae Chinensis, Rhizoma Alpiniae Officinarum: get green tea, Herb Gynostemmae Pentaphylli, Herba Epimedii, Fructus Schisandrae Chinensis, Rhizoma Alpiniae Officinarum and carry out CO respectively
2The extraction of supercritical technological method for processing obtains the finished product powder after drying.Every 100Kg crude drug extraction 2.5Kg finished product powder.
C. the preparation of Sporoderm-broken Ganoderma Lucidum Spore powder: Ganoderma spore powder is smashed the Ganoderma spore powder wall after machining, and sporoderm-broken rate should be more than 90%.
D. the preparation of red ganoderma, the Radix Astragali, Rhizoma Curcumae, Herba Scutellariae Barbatae, Radix Zanthoxyli, Herba Chelidonii, Radix Isatidis, Radix Rehmanniae Preparata, Fructus Jujubae, essence of Job's tears powder: get red ganoderma, the Radix Astragali, Rhizoma Curcumae, Herba Scutellariae Barbatae, Radix Zanthoxyli, Herba Chelidonii, Radix Isatidis, Radix Rehmanniae Preparata, Fructus Jujubae, Semen Coicis, carry out the High Temperature High Pressure extraction respectively.Every kind of medicine adds the water of ten times of weight at every turn, and temperature 90-100 ℃, two atmospheric pressure, three extraction ingredients: two hours for the first time, one and a half hours for the second time, one hour for the third time.Extracting solution is taken out in each back of extracting, and three extracting solution are mixed, and makes smart powder after drying.Every 100kg crude drug is made smart powder 2.5kg.
E. medicament preparation: the medical material powder that above a-d is prepared respectively, by the components by weight percent proportioning mix homogeneously encapsulation of aforementioned drug prescription, standby.
Claims (2)
1. Chinese medicine medicine for preventing powder, it is characterized in that: it is made up of following each components by weight percent proportioning:
Snake venom microcrystalline Cellulose clathrate 5-7g
Green tea CO
2Supercritical extract 70-90g
Herb Gynostemmae Pentaphylli CO
2Supercritical extract 70-90g
Herba Epimedii CO
2Supercritical extract 70-90g
Fructus Schisandrae Chinensis CO
2Supercritical extract 10-30g
Rhizoma Alpiniae Officinarum CO
2Supercritical extract 10-30g
The smart powder 110-130g of red ganoderma Sporoderm-broken Ganoderma Lucidum Spore powder 12-15g
The smart powder 70-90g of the smart powder 30-50g of Rhizoma Curcumae Herba Scutellariae Barbatae
The smart powder 10-30g of the smart powder 10-30g of Radix Zanthoxyli Herba Chelidonii
The smart powder 100-130g of essence of Job's tears powder 70-90g Fructus Jujubae
The smart powder 63-90g of the smart powder 30-50g of Radix Isatidis Radix Rehmanniae Preparata
Radix Astragali essenc powder 103-115g.
2. the preparation method of a kind of Chinese medicine medicine for preventing powder according to claim 1 is characterized in that:
The step of preparation method is:
A. the preparation of snake venom microcrystalline Cellulose clathrate: get cobra venom 3g, agkistrodon halyx pallas venom 3g adds enteric solubility microcrystalline Cellulose 122g, grinds behind mix homogeneously and makes clathrate.
B. the preparation of green tea, Herb Gynostemmae Pentaphylli, Herba Epimedii, Fructus Schisandrae Chinensis, Rhizoma Alpiniae Officinarum: get green tea, Herb Gynostemmae Pentaphylli, Herba Epimedii, Fructus Schisandrae Chinensis, Rhizoma Alpiniae Officinarum and carry out CO respectively
2The extraction of supercritical technological method for processing obtains the finished product powder after drying.Every 100Kg crude drug extraction 2.5Kg finished product powder.
C. the preparation of Sporoderm-broken Ganoderma Lucidum Spore powder: Ganoderma spore powder is smashed the Ganoderma spore powder wall after machining, and sporoderm-broken rate should be more than 90%.
D. the preparation of red ganoderma, the Radix Astragali, Rhizoma Curcumae, Herba Scutellariae Barbatae, Radix Zanthoxyli, Herba Chelidonii, Radix Isatidis, Radix Rehmanniae Preparata, Fructus Jujubae, essence of Job's tears powder: get red ganoderma, the Radix Astragali, Rhizoma Curcumae, Herba Scutellariae Barbatae, Radix Zanthoxyli, Herba Chelidonii, Radix Isatidis, Radix Rehmanniae Preparata, Fructus Jujubae, Semen Coicis, carry out the High Temperature High Pressure extraction respectively.Every kind of medicine adds the water of ten times of weight at every turn, and temperature 90-100 ℃, two atmospheric pressure, three extraction ingredients: two hours for the first time, one and a half hours for the second time, one hour for the third time.Extracting solution is taken out in each back of extracting, and three extracting solution are mixed, and makes smart powder after drying.Every 100kg crude drug is made smart powder 2.5kg.
E. medicament preparation: the medical material powder that above a-d is prepared respectively, by the components by weight percent proportioning mix homogeneously encapsulation of aforementioned drug prescription, standby.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102357212A (en) * | 2011-10-12 | 2012-02-22 | 福建华尔康生物科技有限公司 | Compound product obtained through supercritical CO2 extraction, and preparation method thereof |
| CN105596889A (en) * | 2016-01-22 | 2016-05-25 | 益倍（天津）生物科技有限公司 | Antitumor composition containing resveratrol and preparation method of antitumor composition |
| US10098924B1 (en) | 2018-01-23 | 2018-10-16 | King Saud University | Anticancer extracts of Alpinia officinarum hance |
| CN112755154A (en) * | 2021-02-05 | 2021-05-07 | 温淑贻 | Anticancer traditional Chinese medicine, anticancer traditional Chinese medicine granule and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1394646A (en) * | 2001-07-06 | 2003-02-05 | 滕树材 | Anticancer Chinese medicine powder preparation and its preparation method |
| CN1399976A (en) * | 2001-07-30 | 2003-03-05 | 滕树材 | Chinese medicine powder preparation for resisting thrombosis and its preparation method |
| CN1846780A (en) * | 2006-02-16 | 2006-10-18 | 韩继世 | Anticancer analgetic Chinese medicine composition and its prepn process |
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2010
- 2010-03-10 CN CN201010125701XA patent/CN101804175B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1394646A (en) * | 2001-07-06 | 2003-02-05 | 滕树材 | Anticancer Chinese medicine powder preparation and its preparation method |
| CN1399976A (en) * | 2001-07-30 | 2003-03-05 | 滕树材 | Chinese medicine powder preparation for resisting thrombosis and its preparation method |
| CN1846780A (en) * | 2006-02-16 | 2006-10-18 | 韩继世 | Anticancer analgetic Chinese medicine composition and its prepn process |
Non-Patent Citations (1)
| Title |
|---|
| 《世界元素医学》 20040630 诸葛纯英等 几种抗癌延缓衰老中药微量元素研究 49-51 1-2 第11卷, 第2期 2 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102357212A (en) * | 2011-10-12 | 2012-02-22 | 福建华尔康生物科技有限公司 | Compound product obtained through supercritical CO2 extraction, and preparation method thereof |
| CN102357212B (en) * | 2011-10-12 | 2013-05-29 | 福建华尔康生物科技有限公司 | Compound product obtained through supercritical CO2 extraction, and preparation method thereof |
| CN105596889A (en) * | 2016-01-22 | 2016-05-25 | 益倍（天津）生物科技有限公司 | Antitumor composition containing resveratrol and preparation method of antitumor composition |
| US10098924B1 (en) | 2018-01-23 | 2018-10-16 | King Saud University | Anticancer extracts of Alpinia officinarum hance |
| CN112755154A (en) * | 2021-02-05 | 2021-05-07 | 温淑贻 | Anticancer traditional Chinese medicine, anticancer traditional Chinese medicine granule and preparation method thereof |
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| CN101804175B (en) | 2011-11-30 |
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