CN1842337B - 稳定的5,10-亚甲基四氢叶酸盐药物组合物 - Google Patents
稳定的5,10-亚甲基四氢叶酸盐药物组合物 Download PDFInfo
- Publication number
- CN1842337B CN1842337B CN2004800177913A CN200480017791A CN1842337B CN 1842337 B CN1842337 B CN 1842337B CN 2004800177913 A CN2004800177913 A CN 2004800177913A CN 200480017791 A CN200480017791 A CN 200480017791A CN 1842337 B CN1842337 B CN 1842337B
- Authority
- CN
- China
- Prior art keywords
- pharmaceutical composition
- methylene
- tetrahydrofolic acid
- vitamin
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims (19)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH01123/03A CH697021A5 (de) | 2003-06-26 | 2003-06-26 | Stabile pharmazeutische Zusammensetzungen von 5, 10-Methylentetrahydrofolat. |
CH20031123/03 | 2003-06-26 | ||
PCT/EP2004/006944 WO2004112761A2 (de) | 2003-06-26 | 2004-06-28 | Stabile pharmazeutische zusammensetzungen von 5,10-methylentetrahydrofolat |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1842337A CN1842337A (zh) | 2006-10-04 |
CN1842337B true CN1842337B (zh) | 2010-05-26 |
Family
ID=33520351
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2004800177913A Active CN1842337B (zh) | 2003-06-26 | 2004-06-28 | 稳定的5,10-亚甲基四氢叶酸盐药物组合物 |
Country Status (16)
Country | Link |
---|---|
US (2) | US9180128B2 (zh) |
EP (1) | EP1641460B1 (zh) |
JP (1) | JP4755980B2 (zh) |
KR (1) | KR101156074B1 (zh) |
CN (1) | CN1842337B (zh) |
AT (1) | ATE439842T1 (zh) |
AU (1) | AU2004248923B2 (zh) |
CA (1) | CA2529531C (zh) |
CH (2) | CH697021A5 (zh) |
DE (1) | DE502004009927D1 (zh) |
ES (1) | ES2334030T3 (zh) |
MX (1) | MXPA05014232A (zh) |
PT (1) | PT1641460E (zh) |
RU (1) | RU2343923C2 (zh) |
WO (1) | WO2004112761A2 (zh) |
ZA (1) | ZA200510349B (zh) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH697021A5 (de) * | 2003-06-26 | 2008-03-31 | Merck Eprova Ag | Stabile pharmazeutische Zusammensetzungen von 5, 10-Methylentetrahydrofolat. |
US20090221594A1 (en) * | 2005-12-02 | 2009-09-03 | Chen Andrew X | Stable pharmaceutical compositions of 5, 10 methylenetrahydrofolate |
EP2598148A4 (en) * | 2010-07-28 | 2014-05-28 | Eagle Pharmaceuticals Inc | PHARMACEUTICAL COMPOSITIONS CONTAINING PEMETREXED HAVING EXTENDED STORAGE STABILITY |
CN102827272B (zh) * | 2010-11-08 | 2014-04-02 | 上海汉升生物科技有限公司 | 一种叶酸偶联抗体药物及其制备方法与应用 |
EP2617422A1 (en) | 2012-01-20 | 2013-07-24 | Isofol Medical AB | Anti-tumor activity of reduced folates like methylene-tetrahydrofolate, tetrahydrofolate or methyl-tetrahydrofolate |
EP2617421A1 (en) | 2012-01-20 | 2013-07-24 | Isofol Medical AB | Tetrahydrofolates in combination with EGFR-inhibitors in the use of treating cancer |
KR101260636B1 (ko) * | 2012-11-29 | 2013-05-13 | 씨제이제일제당 (주) | 안정화된 페메트렉시드 제제 |
EP2799060A1 (en) * | 2013-04-30 | 2014-11-05 | Aprofol AG | Stable high dose pharmaceutical composition comprising levoleucovorin |
EP2799061A1 (en) | 2013-04-30 | 2014-11-05 | Aprofol AG | Stable high dose pharmaceutical composition containing folates |
EP2837631A1 (en) * | 2013-08-14 | 2015-02-18 | Merck & Cie | New stable salt of 5,10-methylene-(6R)-tetrahydrofolic acid |
US10059710B2 (en) | 2016-02-17 | 2018-08-28 | Merck & Cie | Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid |
US20170239250A1 (en) | 2016-02-19 | 2017-08-24 | Eagle Pharmaceuticals, Inc. | Pemetrexed formulations |
DK3668516T3 (da) * | 2017-08-16 | 2021-12-13 | Merck Patent Gmbh | Stabile lyofilisater omfattende 5,10-methylen-(6r)-tetrahydrofolsyre og en dicarboxylsyre |
WO2023237483A1 (en) | 2022-06-08 | 2023-12-14 | Merck Patent Gmbh | Concentrated solutions comprising 5,10-methylene-(6r)-tetrahydrofolic acid |
WO2023237485A1 (en) | 2022-06-08 | 2023-12-14 | Merck Patent Gmbh | Stable lyophilisates comprising 5,10-methylene-(6r)-tetrahydrofolic acid |
WO2023237480A1 (en) | 2022-06-08 | 2023-12-14 | Merck Patent Gmbh | Stable pharmaceutical compositions comprising 5,10-methylene-(6r)-tetrahydrofolic acid and nacl |
WO2023237484A1 (en) * | 2022-06-08 | 2023-12-14 | Merck Patent Gmbh | Compositions comprising disodium 5,10-methylene-(6r)-tetrahydrofolate |
WO2023237482A1 (en) | 2022-06-08 | 2023-12-14 | Merck Patent Gmbh | Concentrated solutions comprising sodium 5,10-methylene-(6r)- tetrahydrofolate |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4931441A (en) * | 1988-11-09 | 1990-06-05 | Luitpold Pharmaceuticals, Inc. | Stabilized aqueous leucovorin calcium compositions |
US5434087A (en) * | 1993-02-24 | 1995-07-18 | Abbott Laboratories | Folate immunoassay utilizing folate binding protein in a multiclonal antibody format |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL9400530A (nl) | 1994-04-05 | 1995-11-01 | Pharmachemie Bv | Stabiele waterige folinaatoplossing. |
PT750907E (pt) * | 1995-06-30 | 2002-08-30 | American Cyanamid Co | Formulacoes de vacinas estaveis para administracao parenterica metodo para a sua utilizacao e processo para a sua preparacao |
ES2218662T3 (es) * | 1996-01-31 | 2004-11-16 | South Alabama Medical Science Foundation | Preparaciones de alimento y vitaminas que contienen isomeros naturales de folatos reducidos. |
US6544994B2 (en) * | 2000-06-07 | 2003-04-08 | Eprov Ag | Pharmaceutical preparation for treating or preventing cardiovascular or neurological disorders by modulating of the activity of nitric oxide synthase |
US20020183277A1 (en) * | 2001-05-15 | 2002-12-05 | Lise Binderup | Combination of vitamin D analogue and pyrimidine nucleoside analogue |
CH697021A5 (de) * | 2003-06-26 | 2008-03-31 | Merck Eprova Ag | Stabile pharmazeutische Zusammensetzungen von 5, 10-Methylentetrahydrofolat. |
-
2003
- 2003-06-26 CH CH01123/03A patent/CH697021A5/de not_active IP Right Cessation
-
2004
- 2004-06-28 US US10/562,200 patent/US9180128B2/en active Active
- 2004-06-28 MX MXPA05014232A patent/MXPA05014232A/es active IP Right Grant
- 2004-06-28 WO PCT/EP2004/006944 patent/WO2004112761A2/de active Application Filing
- 2004-06-28 JP JP2006516067A patent/JP4755980B2/ja active Active
- 2004-06-28 AU AU2004248923A patent/AU2004248923B2/en active Active
- 2004-06-28 AT AT04763030T patent/ATE439842T1/de active
- 2004-06-28 DE DE502004009927T patent/DE502004009927D1/de active Active
- 2004-06-28 KR KR1020057024793A patent/KR101156074B1/ko active IP Right Grant
- 2004-06-28 EP EP04763030A patent/EP1641460B1/de active Active
- 2004-06-28 CH CH00311/05A patent/CH698204B1/de not_active IP Right Cessation
- 2004-06-28 CN CN2004800177913A patent/CN1842337B/zh active Active
- 2004-06-28 RU RU2006102028/15A patent/RU2343923C2/ru active
- 2004-06-28 CA CA2529531A patent/CA2529531C/en active Active
- 2004-06-28 PT PT04763030T patent/PT1641460E/pt unknown
- 2004-06-28 ES ES04763030T patent/ES2334030T3/es active Active
-
2005
- 2005-12-20 ZA ZA200510349A patent/ZA200510349B/en unknown
-
2015
- 2015-10-15 US US14/883,797 patent/US20160030573A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4931441A (en) * | 1988-11-09 | 1990-06-05 | Luitpold Pharmaceuticals, Inc. | Stabilized aqueous leucovorin calcium compositions |
US5434087A (en) * | 1993-02-24 | 1995-07-18 | Abbott Laboratories | Folate immunoassay utilizing folate binding protein in a multiclonal antibody format |
Non-Patent Citations (4)
Title |
---|
M. J. Osborn,et al.The Structure of "Active Formaldehyde"(N5, N10 -MethyleneTetrahydrofolic Acid).Journal of the American Chemical Society82 18.1960,82(18),4921-4927. |
M.J.Osborn,et al.The Structure of "Active Formaldehyde"(N5, N10-MethyleneTetrahydrofolic Acid).Journal of the American Chemical Society82 18.1960,82(18),4921-4927. * |
odin elisabeth,et al.chemical stability and human plasmapharmacokinetics ofreduced folates.Cancer Investigation16 7.1998,16(7),447-455. |
odin elisabeth,et al.chemical stability and human plasmapharmacokinetics ofreduced folates.Cancer Investigation16 7.1998,16(7),447-455. * |
Also Published As
Publication number | Publication date |
---|---|
WO2004112761A3 (de) | 2005-03-03 |
RU2006102028A (ru) | 2007-08-10 |
KR101156074B1 (ko) | 2012-06-20 |
ES2334030T3 (es) | 2010-03-04 |
JP4755980B2 (ja) | 2011-08-24 |
KR20060082035A (ko) | 2006-07-14 |
PT1641460E (pt) | 2009-12-28 |
EP1641460B1 (de) | 2009-08-19 |
CH698204B1 (de) | 2009-06-15 |
DE502004009927D1 (de) | 2009-10-01 |
CA2529531A1 (en) | 2004-12-29 |
ATE439842T1 (de) | 2009-09-15 |
ZA200510349B (en) | 2007-12-27 |
CH697021A5 (de) | 2008-03-31 |
CA2529531C (en) | 2012-02-21 |
CN1842337A (zh) | 2006-10-04 |
WO2004112761A2 (de) | 2004-12-29 |
AU2004248923A1 (en) | 2004-12-29 |
US9180128B2 (en) | 2015-11-10 |
AU2004248923B2 (en) | 2010-12-02 |
EP1641460A2 (de) | 2006-04-05 |
RU2343923C2 (ru) | 2009-01-20 |
JP2009514776A (ja) | 2009-04-09 |
MXPA05014232A (es) | 2006-02-24 |
US20160030573A1 (en) | 2016-02-04 |
US20070099866A1 (en) | 2007-05-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: MERCK + CIE PARTNERSHIP CORPORATION Free format text: FORMER OWNER: MERCK EPROVA AG Effective date: 20110512 |
|
C41 | Transfer of patent application or patent right or utility model | ||
C56 | Change in the name or address of the patentee |
Owner name: MERCK + CIE CORPORATION Free format text: FORMER NAME: MERCK + CIE PARTNERSHIP CORPORATION |
|
CP01 | Change in the name or title of a patent holder |
Address after: Schaffhausen Patentee after: Eprova AG Address before: Schaffhausen Patentee before: Merck and Seay partnership |
|
TR01 | Transfer of patent right |
Effective date of registration: 20110512 Address after: Schaffhausen Patentee after: Merck and Seay partnership Address before: Schaffhausen Patentee before: Merck Eprova AG |