CN1824316A - Liquid used for inhibiting bacterial infection and promoting skin growth - Google Patents
Liquid used for inhibiting bacterial infection and promoting skin growth Download PDFInfo
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- CN1824316A CN1824316A CN 200510024048 CN200510024048A CN1824316A CN 1824316 A CN1824316 A CN 1824316A CN 200510024048 CN200510024048 CN 200510024048 CN 200510024048 A CN200510024048 A CN 200510024048A CN 1824316 A CN1824316 A CN 1824316A
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Abstract
An exterior-applied liquid medicine for suppressing bacterial infection and promoting growth of skin is disclosed. Its advantages are broad spectrum and high effect.
Description
Affiliated technical field
The invention belongs to topical drug formula technique field, can reach and promote wound healing, reduce infection chance and reduce the target of the impaired misery of epidermis.
Background technology
People are in the live and work environment, and the situation through regular meeting runs into skin damage comprises grazing, apparatus wound, scald, burn, bacterial infection or the like.The common feature of these injuries is: open condition appears in epidermis, and pathogenic bacterium very easily grow breeding at wound surface, and the development of traumatic infection is with serious threat to life safety.
Because there is the cause of autoimmune function in human body, the impaired meeting of slight epidermis is healed automatically.But under the certain situation below, if do not adopt the positive therapeutic measure, human body can't spontaneous recovery, and often life security can be subjected to serious threat, and they comprise: the large-area degree of depth is scalded or burn; Large-area decubital ulcer that causes owing to the decline of long-term bed and immunity of organisms etc.
Large-area traumatic infection will cause septicemia.Wound surface formed various toxin and pathogenic bacterium after infection will encroach on the various organs of human body with blood flow rapidly, cause many organ infections and function impaired, form the serious life-threatening impact of secondary behind the empyrosis.
At above-mentioned epidermis injury situation, topmost treatment emphasis is to avoid traumatic infection, needs to promote rapidly the epidermal growth healing simultaneously.And generally, avoid traumatic infection and promote that two such therapeutic goals of wound surface growth healing are conflicting pining down: for promoting epidermal growth, just need provide various epidermal growths needed nutrient substance to wound surface; And the abundant environment of nutrient substance is again the easiest places of growing of pathogenic bacterium.So providing under the needed nourishment of epidermal growth, realizing that antibiotic target is just extremely important.
But because the cause that pathogenic bacterium can make a variation and evolve, pathogenic bacterium tend to various antibacterials are produced the drug resistance variation, cause the antibiotic target in the above-mentioned therapeutic process to be difficult to realize.
Drug-fast pathogenic bacterium are stiffly perplexing the realization of above-mentioned therapeutic goal, become large tracts of land, a deep burn or scald and large tracts of land problem that is very difficult to solve in treating patients with decubitus.
Although the medicine of various treatment burns or scald and decubital ulcer has been arranged at present, but more or less all there are some defectives in these medicines, the medicine that some provide skin repair to grow needed nutrient substance, although can promote the growth of skin, can't tackle the trouble that pathogenic bacterium grow easily; The antibiotic organic drug that some are commonly used, tackling aspect the drug resistance of pathogenic bacterium, all there is not outstanding performance, the medicine that some original therapeutic effect are pretty good, behind some medical institutions' life-time service, the drug resistance phenomenon can appear inevitably, and the root of these drug resistance phenomenons is unavoidable pathogenic bacterium colonies of can't get rid of that exist in the environment of these medical institutions, these floras can form drug resistance inevitably in intersection communication process repeatedly.
For this reason, when the needed nutrient substance of skin growth is provided to wound surface,, and not influenced by the pathogenic bacterium drug resistance, will promote the healing effect of impaired wound surface greatly if can also suppress the pathogenic bacterium growth effectively.Skin nutrition and opposing are infected and the medicine of opposing bacterial resistance is very rare but can have concurrently.
In addition, burn or scald and the medicine that treats patients with decubitus at present commonly used, on dosage form, also exist some unfavorable treatments aspect.The dispenser process that these dosage forms caused, spraying equipment all will contact the tender and lovely wound tissue that has damaged inevitably on different degree, increase the weight of patient's misery.Adopt the mode dispenser of smearing such as mastic, needs, the process of smearing can be damaged wound surface; Flooded the covering of medicine for another example, needed directly compressing wound surface, covering and overbearing conduct can disturb and chafe repairing growth interface; Oil preparation and water preparation owing to hand over difficulty to stay at wound surface, so need smear repeatedly, also cause contacting repeatedly the just wound surface in repair process of interference.
Can find a kind of spraying equipment can not contact and stimulate wound surface for this reason; dispenser process itself is not disturbed the dosage form of wound healing growth; and after dispenser, can form the protecting film of a wound surface; stoping the body fluid volatilization, also is to hand over scabrous problem in the dosage form of above-mentioned treatment of diseases medicine.
Summary of the invention
Promptly can provide skin repair needed nutrient substance in order to reach above-mentioned, can effectively kill various pathogenic bacterium again, avoid traumatic infection, can also avoid various pathogenic bacterium to produce the drug resistance problems to wound surface; And spraying equipment does not also contact impaired wound surface, further adopt the appropriate natural drug that passes through again, improve the painful consciousness of damaged skin and the purpose of promotion wound repair growth, the invention provides the prescription and the dosage form of a uniqueness, satisfied above-mentioned all targets simultaneously.
The technical solution adopted for the present invention to solve the technical problems is:
1. adopt aminoacid kind and mutual proportionate relationship polypeptide and protein, reach the target that promotes the wound healing growth near the water miscible synthetic or natural origin of human body skin;
2. select appropriate polypeptide and protein molecular weight for use, be able to form the film-formation result of polypeptide and albuminous membranae in moisture content volatilization back; Formed and isolated the interface that wound surface contacts with outside air, also had certain ventilating performance;
3. adopt the aqueous dispersion system contain nanometer gold or nanometer silver or nano phase ag_2 o, realize efficient, wide spectrum, the antibiotic target that has no drug resistance; Play the effect that promotes the wound repair growth simultaneously.
4. can produce the painful sensations of burning that refrigerant sensation medicinal ingredient improves patient fire victim scald wound in the employing natural Chinese medicine; Promote the wound repair growth simultaneously.
5. adopt the dosage form that to realize spray pesticide to realize the noncontact insecticide-applying way of spraying equipment and wound surface;
The invention has the beneficial effects as follows: both effectively promoted the wound repair growth, efficiently killed malignant bacteria again, life-time service can not cause drug-resistance of bacteria yet; And can improve the burning sensation of wound surface rapidly; Spraying equipment does not contact wound surface fully in the dispenser process, can not damage and disturb wound healing.
The specific embodiment
Specific embodiment 1:
Get synthetic polypeptide, its aminoacid kind and relative scale and structure type are near the human body skin situation, and its molecular weight is 5～100,000.Be configured to 5% concentration with pure water.
Take from nanometer gold or the nanometer silver or the nano phase ag_2 o aqueous solution of system or commodity, wherein the concentration of nanometer gold or nanometer silver or nano phase ag_2 o is 1000～10000PPM, and its control nanometer gold or nanometer silver or the accumulative dispersant of nano phase ag_2 o are silicon oxide or the titanium oxide microparticles that nanometer arrives micro-meter scale.With above-mentioned polypeptide and protein solution, with nanometer gold or nanometer silver or nano phase ag_2 o solution dilution to 200PPM.
Get the prepared slices of Chinese crude drugs of commodity: Borneolum Syntheticum, Herba Menthae, Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae and Radix Angelicae Sinensis, Radix Rehmanniae, Radix Arnebiae (Radix Lithospermi), the consumption of each flavor decoction pieces are 0.01～3% of final treatment liquid weight.With the water-soluble active ingredient of boiling water extraction, be concentrated to 10% of final treatment total liquid volume then.Mix with aforesaid liquid then, form final treatment liquid.
Adopt the hydraulic sprayer of commodity or other spraying apparatus, medicine liquid spray on wound surface, behind the volatilization moisture, will be formed the medicine film naturally.Spraying in per 12 hours once.Avoid the repressive covering of wound surface as far as possible.Up to wound healing.
Specific embodiment 2:
Get the native protein degradation product, its aminoacid kind and relative scale and structure type are near the human body skin situation, and its molecular weight is 5～70,000.Be configured to 2% concentration with pure water.
Take from nanometer gold or the nanometer silver or the nano phase ag_2 o aqueous solution of system or commodity, wherein the concentration of nanometer gold or nanometer silver or nano phase ag_2 o is 1000～10000PPM, and its control nanometer gold or nanometer silver or the accumulative dispersant of nano phase ag_2 o are silicon oxide or the titanium oxide microparticles that nanometer arrives micro-meter scale.With above-mentioned degrade proteins solution, with nanometer gold or nanometer silver solution dilution 500PPM.
Get the prepared slices of Chinese crude drugs of commodity: Borneolum Syntheticum, Herba Menthae, Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae and Radix Angelicae Sinensis, Radix Rehmanniae, Radix Arnebiae (Radix Lithospermi), the consumption of each flavor decoction pieces are 0.1～3% of final treatment liquid weight.With the water-soluble active ingredient of boiling water extraction, be concentrated to 10% of final treatment total liquid volume then.Mix with aforesaid liquid then, form final treatment liquid.
Adopt the hydraulic sprayer of commodity or other spraying apparatus, medicine liquid spray on wound surface, behind the volatilization moisture, will be formed the medicine film naturally.Spraying in per 12 hours once.Avoid the repressive covering of wound surface as far as possible.Up to wound healing.
Specific embodiment 3:
Get the native protein degradation product, its aminoacid kind and relative scale and structure type are near the human body skin situation, and its molecular weight is 5～70,000.Be configured to 0.2% concentration with pure water.
Take from nanometer gold or the nanometer silver or the nano phase ag_2 o aqueous solution of system or commodity, wherein the concentration of nanometer gold or nanometer silver or nano phase ag_2 o is 1000～10000PPM, and its control nanometer gold or nanometer silver or the accumulative dispersant of nano phase ag_2 o are silicon oxide or the titanium oxide microparticles that nanometer arrives micro-meter scale.Degrade proteins solution with above-mentioned dilutes 50PPM with nanometer silver solution.
Get the prepared slices of Chinese crude drugs of commodity: Borneolum Syntheticum, Herba Menthae, the consumption of each flavor decoction pieces are 0.01～0.1% of final treatment liquid weight.With the water-soluble active ingredient of boiling water extraction, be concentrated to 10% of final treatment total liquid volume then.Mix with aforesaid liquid then, form final treatment liquid.
Adopt the hydraulic sprayer of commodity or other spraying apparatus, medicine liquid spray on wound surface, behind the volatilization moisture, will be formed the medicine film naturally.Spraying in per 12 hours once.Avoid the repressive covering of wound surface as far as possible.Up to wound healing.
Claims (9)
1. liquid that is used to suppress bacterial infection, promotes skin growth is characterized in that existing in the prescription of this liquid three such main portions: broad spectrum antimicrobicide, polypeptide and degrade proteins, natural medicinal ingredient.
2. more according to the described liquid of claim 1, it is characterized in that broad spectrum antimicrobicide wherein, is a kind of nanometer gold or nanometer silver or particulate water solution system of nano phase ag_2 o that is dispersed in the inorganic suspended particulates water solution system that contain.
More according to the particle diameter of the described nanometer gold of claim 2 or nanometer silver or nano phase ag_2 o between 0.1～100 nanometer range; The concentration of nanometer gold or nanometer silver or nano phase ag_2 o is between 1PPM～2000PPM.Further feature is that also the above particle diameter of 75% percentage by weight of the nanometer gold that wherein contains or nanometer silver or nano phase ag_2 o is between 1～30 nanometer; Nanometer gold or nanometer silver or nano phase ag_2 o, the weight concentration in the described liquid of claim 1 is between 5PPM～2000PPM.
4. more according to the described inorganic suspended particulates water solution system of claim 2, it is characterized in that particle diameter is at inorganic silicon oxide or the titanium oxide microparticle of nanometer to micron dimension.These microgranules can form inorganic suspended particulates water solution system in water.
5. more according to the described liquid of claim 1, it is characterized in that wherein polypeptide and protein, is water miscible.
6. more according to described polypeptide of claim 5 and protein, its source can be synthetic, also can be natural, it is characterized in that molecular weight ranges is 1000～100000.
7. more according to the polypeptide and the protein of the described natural origin of claim 6, its source can be from the various albumen of animal with and catabolite; Also can be from the protein of plant or insecticide and its catabolite, especially Bombyxmori Linnaeus and silkworm silk (comprising fibroin and the sericin) albumen that presses silkworm with and catabolite.
8. more according to the described liquid of claim 1, it is characterized in that natural medicinal ingredient wherein, be analgesia in the Chinese medicine, let out fire, heat clearing away, detoxifcation class medicinal ingredient, wherein all or part of Borneolum Syntheticum (Borneolum Syntheticum), Mentholum (perhaps Oleum menthae extract), Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae and Radix Angelicae Sinensis, Radix Rehmanniae, Radix Arnebiae (Radix Lithospermi), Radix Notoginseng, the Flos Carthami of containing.
9. more according to the described natural medicinal ingredient of claim 8, its feature also is all to use the boiling water extraction thing of these Chinese crude drugs.The percentage ratio of the original weight of these Chinese medicines in the described liquid of claim 1 is 0.001～10%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510024048 CN1824316A (en) | 2005-02-25 | 2005-02-25 | Liquid used for inhibiting bacterial infection and promoting skin growth |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510024048 CN1824316A (en) | 2005-02-25 | 2005-02-25 | Liquid used for inhibiting bacterial infection and promoting skin growth |
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| CN1824316A true CN1824316A (en) | 2006-08-30 |
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| CN 200510024048 Pending CN1824316A (en) | 2005-02-25 | 2005-02-25 | Liquid used for inhibiting bacterial infection and promoting skin growth |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104261210A (en) * | 2014-10-29 | 2015-01-07 | 国家电网公司 | Tool special for wire releasing during measuring of grounding resistance of electric transmission line pole tower |
| CN107530050A (en) * | 2015-05-20 | 2018-01-02 | 富士胶片株式会社 | Ultrasonic diagnosis application type contact medium |
| CN107603493A (en) * | 2017-08-31 | 2018-01-19 | 兰溪市拜瑞珂科技服务有限公司 | A kind of fungi-proofing light maintaining agent of fur clothing and preparation method thereof |
-
2005
- 2005-02-25 CN CN 200510024048 patent/CN1824316A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104261210A (en) * | 2014-10-29 | 2015-01-07 | 国家电网公司 | Tool special for wire releasing during measuring of grounding resistance of electric transmission line pole tower |
| CN107530050A (en) * | 2015-05-20 | 2018-01-02 | 富士胶片株式会社 | Ultrasonic diagnosis application type contact medium |
| CN107603493A (en) * | 2017-08-31 | 2018-01-19 | 兰溪市拜瑞珂科技服务有限公司 | A kind of fungi-proofing light maintaining agent of fur clothing and preparation method thereof |
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Open date: 20060830 |