CN1824210A - Anticonsumption preparation and its new preparation method - Google Patents
Anticonsumption preparation and its new preparation method Download PDFInfo
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Abstract
A composite Chinese medicine in the form of dripping pill and soft capsule for treating infiltrative pulmonary tuberculosis and blood-stained sputum, and its preparing process are disclosed.
Description
Technical field:
The present invention relates to a kind of Chinese medicine composition and preparation technology thereof, particularly a kind of infiltrative pulmonary tuberculosis that is used for, the prescription of sputum mixed with blood and preparation technology thereof.
Background technology:
Infiltrative pulmonary tuberculosis, sputum mixed with blood are clinically to see symptom more, and the traditional Chinese medical science is often taked promoting blood circulation and hemostasis, the dissipating blood stasis tissue regeneration promoting, and the means of expelling phlegm for arresting cough are treated it, and evident in efficacy.Anti-consumptive disease ball is that it represents medicine.But in the practice, because this medicine is medical material to be beaten powder be used as medicine in preparation, cause impurity many, shortcoming such as dosage is big has a strong impact on its clinical practice.
The preparation of process extraction process preparation of the present invention is easy to dissolving and absorption than elite and thick putting that ordinary pill more can collect medicine, and curative effect is fast, and administration time is short, and therefore, curative effect is better.
The purpose of this invention is to provide a kind of therapeutic domain wide, easily accept, easily absorb, the preparation technology of efficient, low dosage, the Chinese medicine dripping pills that has no side effect, soft capsule, tablet, chewable tablet, its pill that makes can be used for curing mainly infiltrative pulmonary tuberculosis, sputum mixed with blood.
Summary of the invention:
The present invention relates to a kind of prescription and preparation technology thereof of Chinese medicine preparation, it is characterized in that, the preparation of per 1000 dosage units is prepared from by following proportion raw material:
50～360 parts of 100～720 parts of Cortex Mori of 250～1800 parts of Radixs Stemonae of Herba Ardisiae Japonicae
100～720 parts of 100～720 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) of 100～720 parts of Herba Fici Simplicissimae of Radix Cudraniae
Preferably:
100 parts of 200 parts of Cortex Mori of 500 parts of Radixs Stemonae of Herba Ardisiae Japonicae
200 parts of 200 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) of 200 parts of Herba Fici Simplicissimae of Radix Cudraniae
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton, if be unit with gram, this prescription composition can be made into 1000 doses of pharmaceutical preparatioies.Described 1000 doses of fingers, the final drug preparation of making, as make 1000 of soft capsule preparations, drop pill 1000 balls, granule 1000g etc., also can make big packing as granule, as 100～500 bags, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.
More than form, can be made into the preparation of 50～1000 taking doses,, make 125 bags, take 1～2 bag at every turn, can take altogether 62.5～125 times as granule.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The raw material of Chinese medicine of said ratio extracts processing through new technology of the present invention, obtain the active constituents of medicine of preparation of the present invention, add suitable excipient as required and make suitable medicinal any dosage form, said preparation can be drop pill, soft capsule, tablet, mixture, syrup, unguentum, medicated wine.
The above new technology of the present invention may further comprise the steps:
Method a:(technology 1.)
(1) the prescription medical material decocts with water 2～6 times, and each 0.5～4 hour, collecting decoction filtered, and filtrate is condensed into certain volume, adds 4～12 times of amount 60～95% ethanol mixings, leaves standstill 6～40h, filters, and it is standby that filtrate decompression is condensed into thick extractum;
(2) above active component lumps together the active constituents of medicine into preparation of the present invention.This active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) get Pseudobulbus Bletillae (Rhizoma Bletillae), add 2～20 times of water gagings and adopt ultrasonic extraction (or decocting boils) 2～5 times, each 15～120 minutes, merge extractive liquid, filtered, and filtrate decompression is condensed into thick extractum, and is standby;
(2) get the residue medical material, soaked 30～60 minutes earlier with 50～85% ethanol, reheat reflux, extract, 2～4 times, each 0.5～2 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention.This active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
The active constituents of medicine of the preparation of the present invention that above method obtains can be prepared into preparation of the present invention through further processing.
Preparation of the present invention, different dosage form method difference below is the preparation method of several preferred dosage form.
(1) preparation of drop pill
Drop pill of the present invention, wherein the ratio of active component and adjuvant is 1: 0.5～10, and preferred ratio is 1: 2～4, and most preferred ratio is 1: 3.The above adjuvant be specially molecular weight polyethylene glycol between 400 to 10000 Polyethylene Glycol and their mixture, as PEG400 (PEG400), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture or other suitable other auxiliary elements of making drop pill, as glycerol, gelatin or stearic acid sodium etc.
Following steps are taked in the preparation of drop pill of the present invention:
1. be ready to following raw material: active component, adjuvant and/or other inactive ingredients;
2. with the above-mentioned raw materials mix homogeneously;
3. add the transconversion into heat material, move into the drip irrigation of drop pill machine, medicinal liquid splashes in the liquid sub liquid paraffin by water dropper, removes liquid paraffin, selects ball, promptly.
(2) preparation of soft capsule
Soft capsule preparation of the present invention is that active component and pharmaceutically useful organic solvent and the material of making soft capsule shell are formed.Organic solvent wherein is selected from PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, the material of wherein making soft capsule shell is gelatin or arabic gum, water, plasticizer and antiseptic, the weight ratio of gelatin or arabic gum and plasticizer is 1.0: 0.4～1.0 in the soft capsule shell, and the weight ratio of gelatin and water is 1.0: 0.8～1.2; The content of active component is 50mg～500mg in every soft capsule.
The preparation method of preparation of the present invention, the process following steps:
A. get gelatin, glycerol, pure water adds thermosol, adds an amount of antiseptic, preparation rubber;
B. get active component and be dissolved in organic solvent, add suitable quantity of water, be prepared into soft capsule through encapsulating machine.
(3) preparation method of tablet is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, and drying, tabletting promptly gets chewable tablet.
(4) preparation method of chewable tablet is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, and drying, tabletting promptly gets chewable tablet.
Filler described in the preparation of tablet, chewable tablet is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
Following data declaration beneficial effect of the present invention by experiment:
In order to prove the Clinical feasibility that changes after the technology, we have carried out its main pharmacodynamics, toxicologic study to this medicine, observe its therapeutical effect, and the clinical experimental basis that provides is provided.
One, the experimentation of tuberculosis guinea pig model
1, experimental technique
1.1 40 of qualified Cavia porcelluss are selected in laboratory animal grouping and medication for use, animal is divided into 5 groups at random.Normal control group, model blank group, technology is 2. extractum group, isoniazid group of extractum group, technology 1..Except that the normal control group, all the other are respectively organized in infecting and begin administration after 1 week back tuberculin reaction sun changes, and dosage sees Table 1, irritates stomach (ig), every day 1 time, every day same time administration, continuous 6 weeks (42d).
1.2 after 1 week of observation of curative effect drug withdrawal,, weigh, dissect and carry out the weight of animals after the Drug therapy, the tuberculosis pathological changes index O﹠A of internal organs liver, spleen, lung and injection site sacrifice of animal.Quantitatively take by weighing the part internal organs, wear into certain density The viscera suspension with Potter-Elvehjem Tissue Grinders (adding small amount of N S), getting 0.1ml is inoculated on the modified Russell medium, cultivated for 4 weeks for 37 ℃, record training base is gone up the clump count of growth, calculate into again viable bacteria unit (CFU) in the Unit Weight internal organs organize between relatively.
1.3 experimental data statistical procedures group difference adopts SPSS10.0 version software to test, skewness distributes, nonparametric pairwise correlation sample adopts rank test, normal distribution and parameter pairwise correlation sample adopt the t check, and measurement data is all with mean ± standard deviation (x ± s) expression.
2, result
2.1 influence to the Cavia porcellus body weight
The influence of table 1 pair Cavia porcellus body weight (x ± s)
| Group | Number of animals (only) | Dosage (g/kg) | Body weight after the administration (g) |
| Normal group model group isoniazid technology is 2. extractum group of extractum group technology 1. | 8 8 8 8 8 | - - 0.03 0.19 0.35 | 503.38±18.97 456.78±17.73 * 496.63±13.47 △△ 530.43±16.15 △△ 503.38±10.18 △△ |
Annotate: model blank group and normal control group compare,
*P＜0.001, medication group and model group are relatively
△P＜0.01,
△ △P＜0.001
As shown in Table 1, model blank group Cavia porcellus body weight is starkly lower than normal group (P＜0.001); Administration group Cavia porcellus body weight obviously increases (P＜0.001).
2.2 the execution animal is dissected in the influence of Cavia porcellus pathological changes perusal pathogenic index, and perusal GPS, lung, liver, injection site and tuberculous lymphadenitis lesion degree with the exponential formal representation of pathological changes, see Table 2.
Table 2 Cavia porcellus pathological changes perusal pathogenic index
| Lesion degree | Diseased region | Injection site and lymph node | Pulmonary shadow, trachea, paratracheal lymph nodes | ||
| Spleen | Lung | Liver | |||
| The slight maximum of severe moderate | 35 20 10 35 | 30 20 10 30 | 25 20 10 25 | 10 10 10 10 | 10 10 10 10 |
Each organ disease maximum sum is 100, presses the order of showing according to experimental result and summary of experience substantially for the progress degree of pathological changes, i.e. progress such as spleen, lung, liver, and the observation of pressing table 2, evaluation rule, experimental result sees Table 3.
The influence of table 3 pair Cavia porcellus pathological changes perusal pathogenic index (x ± s, n=8)
| Group | Spleen | Lung | Liver | Injection site and lymph node |
| Normal group model group isoniazid technology is 2. extractum group of extractum group technology 1. | 0 28.50±19.14 * 0 △ 0 △ 0 △ | 0 18.00±6.32 * 1.25±3.54 △ 1.25±3.54 △ 0 △ | 0 22.50±2.64 2.50±4.63 △ 0 1.25±3.54 △ | 0 10.00±0.00 ** 1.25±3.54 △△ 1.25±16.15 △△ 2.50±4.63 △ |
Annotate: model blank group and normal control group compare,
*P＜0.05,
*P＜0.01, medication group and model group are relatively
△P＜0.05,
△ △P＜0.01
By table 3 as seen, the blank group of model pathogenic index is apparently higher than normal control group (P＜0.05 or P＜0.01); Medication group pathogenic index obviously reduces (P＜0.05), near the normal control group.
2.3 to the exponential influence of Cavia porcellus organ weights after certain internal organs is subjected to infection due to Mycobacterium tuberculosis, these internal organs are with pathological changes, enlargement, with the weight of internal organs and the ratio value representation organ disease degree of the weight of animals, it is the organ weights index, the big more lesion degree that then illustrates of this index is heavy more, Cavia porcellus organ weights index the results are shown in Table 4, the organ weights index calculation method:
The table 4 pair exponential influence of Cavia porcellus organ weights (x ± s, n=8)
| Group | Spleen | Lung | Liver |
| Normal group model group isoniazid technology is 2. extractum group of extractum group technology 1. | 0.179±0.009 0.229±0.028 * 0.201±0.041 0.175±0.021 △ 0.175±0.026 △ | 0.797±0.022 1.168±0.110 * 0.830±0.040 △ 0.775±0.068 △ 0.805±0.076 △ | 4.211±0.145 5.483±0.460 * 4.342±0.147 △△ 4.620±0.492 △ 4.570±0.508 △ |
Annotate: model blank group and normal control group compare,
*P＜0.001, medication group and model group are relatively
△P＜0.01,
△ △P＜0.001
Two, toxicological study
Acute toxicity test shows that rat oral gavage extract of the present invention fails to measure LD
50
Long term toxicity test: rat grouping, extract of the present invention is irritated stomach, every day three times, connect and annotate 90d, the result, administration group rat and control rats movable, search for food, drinking-water, body weight and multinomial observation indexs such as substantial viscera pathologic finding and histopathology detect, result of the test is not all found any toxicity; Hemogram and hepatic and renal function index and the equal no significant difference of matched group.
The blood vessel irritation of this medicine, allergy and hemolytic test all are negative.
In sum, preparation of the present invention, dropping pill formulation particularly of the present invention and soft capsule preparation are a kind of good treatment infiltrative pulmonary tuberculosis, the medicine of sputum mixed with blood, and change preparation technology, can obviously strengthen its promoting blood circulation and hemostasis, dissipating blood stasis tissue regeneration promoting, clinical efficacies such as expelling phlegm for arresting cough, its hypotoxicity in addition, therefore prolonged application safety, be worth clinical application.
The specific embodiment:
Further specify the present invention by the following examples, include but not limited to the following example.
Embodiment 1:
The preparation method of drop pill of the present invention:
Prescription:
Herba Ardisiae Japonicae 450g Radix Stemonae 180g Cortex Mori 90g
Radix Cudraniae 180g Herba Fici Simplicissimae 180g Pseudobulbus Bletillae (Rhizoma Bletillae) 180g
PEG4000 100g
Make 1000 balls
Preparation method:
(1) get the prescription medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into certain volume, added 10 times of amount 95% ethanol mixings, left standstill 12h, filtered, and it is standby that filtrate decompression is condensed into thick extractum;
(2) with above-mentioned extract obtained, the PEG4000 that adds recipe quantity puts into the vessel in heating dissolving, and jolting makes and dissolves into uniform solution, inserts in the fluid reservoir.Keep 80 ℃ the system of dripping temperature, and a control speed, condensed fluid is a liquid paraffin, drips system promptly.
Embodiment 2:
Preparation of soft capsule method of the present invention:
Prescription:
Herba Ardisiae Japonicae 1800g Radix Stemonae 720g Cortex Mori 360g
Radix Cudraniae 720g Herba Fici Simplicissimae 720g Pseudobulbus Bletillae (Rhizoma Bletillae) 720g
PEG400 400g
Make 1000
Preparation method:
(1) get the prescription medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into certain volume, added 10 times of amount 95% ethanol mixings, left standstill 12h, filtered, and it is standby that filtrate decompression is condensed into thick extractum;
(2) with above-mentioned extract obtained, add an amount of PEG400 and mix and mixing, add the PEG400 of surplus then, promptly get medicinal liquid.It is standby in addition to join gelatin solution by certain prescription.The condition that control is suitable is regulated content weight, obtains soft capsule in the soft capsule machine.
Embodiment 3:
The preparation method of tablet of the present invention:
Prescription:
Herba Ardisiae Japonicae 700g Radix Stemonae 280g Cortex Mori 140g
Radix Cudraniae 280g Herba Fici Simplicissimae 280g Pseudobulbus Bletillae (Rhizoma Bletillae) 280g
Make 1000
Preparation method:
(1) get Pseudobulbus Bletillae (Rhizoma Bletillae), add 5 times of water gagings and adopt ultrasonic extraction 2 times, each 40 minutes, merge extractive liquid, filtered, and filtrate decompression is condensed into thick extractum, and is standby;
(2) get the residue medical material, soaked 40 minutes earlier with 75% ethanol, reheat reflux, extract, 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) above active component is merged, add aspartame 5.0g, mannitol 200.0g, granulation, drying adds magnesium stearate 3.0g, mixing, and tabletting promptly gets 1000.
Embodiment 4:
The preparation method of chewable tablet of the present invention:
Prescription:
Herba Ardisiae Japonicae 700g Radix Stemonae 280g Cortex Mori 140g
Radix Cudraniae 280g Herba Fici Simplicissimae 280g Pseudobulbus Bletillae (Rhizoma Bletillae) 280g
Make 1000
Preparation method:
(1) get Pseudobulbus Bletillae (Rhizoma Bletillae), add 5 times of water gagings and adopt ultrasonic extraction 2 times, each 40 minutes, merge extractive liquid, filtered, and filtrate decompression is condensed into thick extractum, and is standby;
(2) get the residue medical material, soaked 40 minutes earlier with 75% ethanol, reheat reflux, extract, 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) above active component is merged, add aspartame 3.0g, mannitol 200.0g, granulation, drying adds magnesium stearate 3.0g, mixing, and tabletting promptly gets 1000 of chewable tablet.
Claims (10)
1, a kind of Chinese medicine preparation is characterized in that per 1000 dosage units are made by the following weight proportion raw material:
50～360 parts of 100～720 parts of Cortex Mori of 250～1800 parts of Radixs Stemonae of Herba Ardisiae Japonicae
100～720 parts of 100～720 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) of 100～720 parts of Herba Fici Simplicissimae of Radix Cudraniae.
2, the compound preparation of claim 1 is characterized in that, per 1000 dosage units are made by the following weight proportion raw material:
100 parts of 200 parts of Cortex Mori of 500 parts of Radixs Stemonae of Herba Ardisiae Japonicae
200 parts of 200 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) of 200 parts of Herba Fici Simplicissimae of Radix Cudraniae.
3, claim 1 or any one Chinese medicine preparation of 2 are drop pill, soft capsule, tablet, mixture, syrup, unguentum, medicated wine.
4, the Chinese medicine preparation of claim 3 through described raw material is extracted processing, obtains active component, adds suitable adjuvant as required and makes.
5, the Chinese medicine preparation of claim 4 is characterized in that, described active component prepares through following steps:
Method a:(technology 1.)
(1) the prescription medical material decocts with water 2～6 times, and each 0.5～4 hour, collecting decoction filtered, and filtrate is condensed into certain volume, adds 4～12 times of amount 60～95% ethanol mixings, leaves standstill 6～40h, filters, and it is standby that filtrate decompression is condensed into thick extractum;
(2) above active component lumps together the active constituents of medicine into preparation of the present invention.This active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) get Pseudobulbus Bletillae (Rhizoma Bletillae), add 2～20 times of water gagings and adopt ultrasonic extraction (or decocting boils) 2～5 times, each 15～120 minutes, merge extractive liquid, filtered, and filtrate decompression is condensed into thick extractum, and is standby;
(2) get the residue medical material, soaked 30～60 minutes earlier with 50～85% ethanol, reheat reflux, extract, 2～4 times, each 0.5～2 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention.This active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
6, the Chinese medicine preparation of claim 5 is characterized in that:
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
7, the Chinese medicine preparation of claim 5 is characterized in that:
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: with active constituents of medicine and proper auxiliary materials mix homogeneously, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
8, the Chinese medicine preparation of claim 5 is characterized in that:
The preparation method of tablet is as follows: with above-mentioned extract obtained, adds a certain amount of filler, correctives, lubricant, granulates, and drying, tabletting promptly gets chewable tablet.
The preparation method of chewable tablet is as follows: with above-mentioned extract obtained, adds a certain amount of filler, correctives, lubricant, granulates, and drying, tabletting promptly gets chewable tablet.
9, the Chinese medicine preparation of claim 8 is characterized in that:
Described filler is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
10, the preparation method of any one Chinese medicine preparation of claim 1～9 is characterized in that, the process following steps:
Described raw material of Chinese medicine is extracted processing, obtain active component, add suitable adjuvant and make; Wherein said active component prepares through following steps:
Method a:(technology 1.)
(1) the prescription medical material decocts with water 2～6 times, and each 0.5～4 hour, collecting decoction filtered, and filtrate is condensed into certain volume, adds 4～12 times of amount 60～95% ethanol mixings, leaves standstill 6～40h, filters, and it is standby that filtrate decompression is condensed into thick extractum;
(2) above active component lumps together the active constituents of medicine into preparation of the present invention.This active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) get Pseudobulbus Bletillae (Rhizoma Bletillae), add 2～20 times of water gagings and adopt ultrasonic extraction (or decocting boils) 2～5 times, each 15～120 minutes, merge extractive liquid, filtered, and filtrate decompression is condensed into thick extractum, and is standby;
(2) get the residue medical material, soaked 30～60 minutes earlier with 50～85% ethanol, reheat reflux, extract, 2～4 times, each 0.5～2 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention.This active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: active constituents of medicine is mixed with proper auxiliary materials, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510134412 CN1824210A (en) | 2005-12-15 | 2005-12-15 | Anticonsumption preparation and its new preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510134412 CN1824210A (en) | 2005-12-15 | 2005-12-15 | Anticonsumption preparation and its new preparation method |
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| Publication Number | Publication Date |
|---|---|
| CN1824210A true CN1824210A (en) | 2006-08-30 |
Family
ID=36935154
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510134412 Pending CN1824210A (en) | 2005-12-15 | 2005-12-15 | Anticonsumption preparation and its new preparation method |
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| CN (1) | CN1824210A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103356821A (en) * | 2013-07-23 | 2013-10-23 | 黎秋萍 | Chinese herbal medicine processing and bamboo tube canning method |
-
2005
- 2005-12-15 CN CN 200510134412 patent/CN1824210A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103356821A (en) * | 2013-07-23 | 2013-10-23 | 黎秋萍 | Chinese herbal medicine processing and bamboo tube canning method |
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