CN1816350B - 带有几丁聚糖佐剂和/或脑膜炎抗原的粘膜疫苗 - Google Patents

带有几丁聚糖佐剂和/或脑膜炎抗原的粘膜疫苗 Download PDF

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Publication number
CN1816350B
CN1816350B CN038166593A CN03816659A CN1816350B CN 1816350 B CN1816350 B CN 1816350B CN 038166593 A CN038166593 A CN 038166593A CN 03816659 A CN03816659 A CN 03816659A CN 1816350 B CN1816350 B CN 1816350B
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China
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composition
chitosan
antigen
antigens
immune response
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Expired - Fee Related
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CN038166593A
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English (en)
Chinese (zh)
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CN1816350A (zh
Inventor
G·德尔古迪斯
B·宝德纳
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LEIDEN UNIV
Novartis Vaccines and Diagnostics Inc
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Chiron SRL
Universiteit Leiden
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Priority claimed from GBGB0302218.3A external-priority patent/GB0302218D0/en
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Publication of CN1816350A publication Critical patent/CN1816350A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55583—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN038166593A 2002-05-14 2003-05-14 带有几丁聚糖佐剂和/或脑膜炎抗原的粘膜疫苗 Expired - Fee Related CN1816350B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US38067502P 2002-05-14 2002-05-14
US60/380,675 2002-05-14
GB0302218.3 2003-01-30
GBGB0302218.3A GB0302218D0 (en) 2003-01-30 2003-01-30 Vaccine formulation & Mucosal delivery
PCT/IB2003/002382 WO2003094834A2 (en) 2002-05-14 2003-05-14 Mucosal vaccines with chitosan adjuvant and meningococcal antigens

Publications (2)

Publication Number Publication Date
CN1816350A CN1816350A (zh) 2006-08-09
CN1816350B true CN1816350B (zh) 2010-11-10

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN038166593A Expired - Fee Related CN1816350B (zh) 2002-05-14 2003-05-14 带有几丁聚糖佐剂和/或脑膜炎抗原的粘膜疫苗
CN038166585A Expired - Fee Related CN1684707B (zh) 2002-05-14 2003-05-14 用于细菌性脑膜炎的粘膜结合疫苗

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Application Number Title Priority Date Filing Date
CN038166585A Expired - Fee Related CN1684707B (zh) 2002-05-14 2003-05-14 用于细菌性脑膜炎的粘膜结合疫苗

Country Status (12)

Country Link
US (2) US20060147466A1 (https=)
EP (1) EP1506007B1 (https=)
JP (2) JP4662537B2 (https=)
CN (2) CN1816350B (https=)
AT (1) ATE513560T1 (https=)
AU (1) AU2003239744B2 (https=)
BR (1) BR0310042A (https=)
CA (1) CA2485999C (https=)
MX (1) MXPA04011248A (https=)
NZ (1) NZ536859A (https=)
RU (1) RU2378008C2 (https=)
WO (1) WO2003094960A2 (https=)

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NZ550533A (en) 2004-04-30 2010-02-26 Novartis Vaccines & Diagnostic Meningococcal conjugate vaccination comprising N. meningitidis and diphtheria toxin
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CN104383531A (zh) * 2014-11-18 2015-03-04 北京智飞绿竹生物制药有限公司 预防儿童脑膜炎的联合疫苗及其制备方法
WO2016132294A1 (en) 2015-02-19 2016-08-25 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
CN105031644A (zh) * 2015-06-25 2015-11-11 中国科学院过程工程研究所 一种疫苗佐剂及含该疫苗佐剂的疫苗组合物和疫苗制剂
CN106606775A (zh) * 2015-10-27 2017-05-03 格里菲斯大学 脂质体a群链球菌疫苗
AU2018215585B2 (en) 2017-01-31 2022-03-17 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
AU2018243910B2 (en) 2017-03-28 2025-04-10 The Children's Medical Center Corporation A multiple antigen presenting system (MAPS)-based staphylococcus aureus vaccine, immunogenic composition, and uses thereof
US10729763B2 (en) 2017-06-10 2020-08-04 Inventprise, Llc Mixtures of polysaccharide-protein pegylated compounds
WO2018227177A1 (en) 2017-06-10 2018-12-13 Inventprise, Llc Multivalent conjugate vaccines with bivalent or multivalent conjugate polysaccharides that provide improved immunogenicity and avidity
MX2019015524A (es) 2017-06-23 2020-09-10 Univ Maryland Composiciones inmunogenicas.
SG11202101973YA (en) 2018-09-12 2021-03-30 Childrens Medical Ct Corp Pneumococcal fusion protein vaccines
CN112969474A (zh) 2018-09-12 2021-06-15 艾芬尼维克斯公司 多价肺炎球菌疫苗
RU2704452C1 (ru) * 2019-04-22 2019-10-28 Федеральное государственное унитарное предприятие "Санкт-Петербургский научно-исследовательский институт вакцин и сывороток и предприятие по производству бактерийных препаратов" Федерального медико-биологического агентства Способ получения вакцины гемофильной тип b конъюгированной
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Also Published As

Publication number Publication date
MXPA04011248A (es) 2005-02-17
RU2378008C2 (ru) 2010-01-10
AU2003239744A1 (en) 2003-11-11
NZ536859A (en) 2007-11-30
ATE513560T1 (de) 2011-07-15
JP2010202672A (ja) 2010-09-16
US20060147466A1 (en) 2006-07-06
WO2003094960A2 (en) 2003-11-20
CN1684707B (zh) 2012-09-05
JP2005526847A (ja) 2005-09-08
CA2485999C (en) 2015-02-17
EP1506007B1 (en) 2011-06-22
CN1684707A (zh) 2005-10-19
AU2003239744B2 (en) 2008-07-03
JP4662537B2 (ja) 2011-03-30
RU2004136295A (ru) 2006-03-20
EP1506007A2 (en) 2005-02-16
CN1816350A (zh) 2006-08-09
BR0310042A (pt) 2005-04-05
CA2485999A1 (en) 2003-11-20
WO2003094960A3 (en) 2004-03-04
US20110159030A1 (en) 2011-06-30

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Address after: Leiden

Co-patentee after: Novartis Vaccines & Diagnostic

Patentee after: Leiden Univ.

Address before: Leiden

Co-patentee before: Chiron S. P. A.

Patentee before: Leiden Univ.

CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20101110

Termination date: 20170514

CF01 Termination of patent right due to non-payment of annual fee