CN1807634A - Corynebacterium glutamicum genes encoding proteins involved in carbon metabolism and energy production - Google Patents

Abstract

The present invention provides an isolated nucleic acid molecules, designated SMP nucleic acid molecules, which encode novel SMP proteins from Corynebacterium glutamicum. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SMP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated SMP proteins, mutated SMP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of SMP genes in this organism.

Description

The proteinic Corynebacterium glutamicum gene that coding involved in carbon metabolism and energy produce

The application is to be on June 23rd, 2000 applying date, and application number is 00811819.1, and denomination of invention is divided an application for the application for a patent for invention of " the proteinic Corynebacterium glutamicum gene that coding involved in carbon metabolism and energy produce ".

Related application

The application requires the right of priority of the United States Patent (USP) provisional application sequence number 60/151572 of the United States Patent (USP) provisional application sequence number 60/143208 of U.S. Provisional Patent Application sequence number (SN) application July 9 in 60/141031,1999 of on June 25th, 1999 application and application on August 31st, 1999.This application also requires the right of priority of following patent application: the German patent application of on July 8th, 1999 application numbers 19931412.8, the German patent application of on July 8th, 1999 application numbers 19931413.6, the German patent application of on July 8th, 1999 application numbers 19931419.5, the German patent application of on July 8th, 1999 application numbers 19931420.9, the German patent application of on July 8th, 1999 application numbers 19931424.1, the German patent application of on July 8th, 1999 application numbers 199314284, the German patent application of on July 8th, 1997 application numbers 19931431.4, the German patent application of on July 8th, 1999 application numbers 19931433.0, the German patent application of on July 8th, 1999 application numbers 19931434.9, the German patent application of on July 8th, 1999 application numbers 19931510.8, the German patent application of on July 8th, 1999 application numbers 19931562.0, the German patent application of on July 8th, 1999 application numbers 19931634.1, the German patent application of on July 9th, 1999 application numbers 19932180.9, the German patent application of on July 9th, 1999 application numbers 19932227.9, the German patent application of on July 9th, 1999 application numbers 19932230.9, the German patent application of on July 14th, 1999 application numbers 19932924.9, the German patent application of on July 14th, 1999 application numbers 19932973.7, the German patent application of on July 14th, 1999 application numbers 19933005.0, the German patent application of on August 27th, 1999 application numbers 19940765.7, the German patent application of on September 3rd, 1999 application numbers 19942076.9, the German patent application of on September 3rd, 1999 application numbers 19942079.3, the German patent application of on September 3rd, 1999 application numbers 19942086.6, the German patent application of on September 3rd, 1999 application numbers 19942087.4, the German patent application of on September 3rd, 1999 application numbers 19942088.2, the German patent application of on September 3rd, 1999 application numbers 19942095.5, the German patent application of the German patent application of on September 3rd, 1999 application number application on September 3rd, 19942123.4 and 1999 numbers 19942125.0.The full content of all above cited application all is attached to herein especially by reference.

Background of invention

Some product of the metabolic process of natural generation and by product have practicality in multiple industry in cell, and described industry comprises foodstuffs industry, fodder industry, cosmetic industry and pharmacy industry.These molecules are referred to as " fine chemicals ", comprise amino acid, Nucleotide and nucleosides, lipid and lipid acid, dibasic alcohol, carbohydrate, aromatic substance, VITAMIN and cofactor and enzyme that organic acid, proteinogenous and nonprotein generate.Their production is to need the large scale culturing of the bacterium of molecule to carry out by exploitation in order to produce and to secrete a large amount of one or more the most easily.A kind of useful especially biology that is used for this purpose is Corynebacterium glutamicum (Corynebacterium glutamicum), and this is a kind of gram-positive non-pathogenic bacteria.By the selection of bacterial strain, a series of saltants that need compound of many generations have been developed.Yet being chosen in the improved bacterial strain in specific molecular production aspect is a time-consuming and difficult process.

Brief summary of the invention

The invention provides the novel bacteria nucleic acid molecule that serves many purposes.These purposes comprise that evaluation can be used for producing the microorganism of fine chemicals, adjusting Corynebacterium glutamicum or Related Bacteria and produce fine chemicals, typing or evaluation Corynebacterium glutamicum or Related Bacteria, is used as the reference point of Corynebacterium glutamicum gene group mapping and is used as the mark that transforms.These novel nucleic acids molecule encodings be called herein carbohydrate metabolism and oxidative phosphorylation ( sUgar mEtabolism and_oxidative pHosphorylation) (SMP) proteic protein.

Corynebacterium glutamicum is a kind of Gram-positive aerophil, is generally used for the miscellaneous fine chemicals of large-scale commercial production, the oxidation that also is used for degradable carbon hydrogen compound (for example being used to handle the oil overspill) and is used for terpenoid.Therefore, SMP nucleic acid molecule of the present invention can be used for identifying the microorganism that can for example produce fine chemicals by fermenting process.The modification of the adjusting of SMP expression of nucleic acid of the present invention or SMP sequence of nucleic acid molecules of the present invention can be in order to the production (for example improving the productive rate or the output of one or more fine chemicals of various excellent bacillus or tyrothricin) of one or more fine chemicals of regulating microorganism.

SMP nucleic acid of the present invention also can be used for identifying the biology of Corynebacterium glutamicum or its closely related bacterial classification, or is used for identifying in the mixing microorganisms colony that whether Corynebacterium glutamicum or its relevant bacterial classification exist.The invention provides the nucleotide sequence of multiple Corynebacterium glutamicum gene; By probe with the section of crossing over the peculiar gene of Corynebacterium glutamicum, under stringent condition, survey the genomic dna of the extraction of peculiar microbial population culture or mixing microorganisms colony culture, people can determine whether this biology exists.Though Corynebacterium glutamicum itself is a non-virulent, it with the mankind in pathogenic species for example corynebacterium diphtheriae (Corynebacterium diphtheriae) (diphtheria pathogenic agent) is relevant; Detection to this class biology has important clinical significance.

SMP nucleic acid molecule of the present invention also can be as the reference point of Corynebacterium glutamicum gene group or associated biomolecule genomic mapping.Equally, these molecules and varient thereof or its part can be as the marks of genetic engineering rod bacillus or tyrothricin bacterial classification.

The SMP albumen of novel nucleic acids molecule encoding of the present invention can for example be carried out in Corynebacterium glutamicum and relate to the metabolic function of carbon compound (for example sugar), or execution relates to by the function such as oxidative phosphorylation process generate energy molecule.The known cloning vector that obtains being used for Corynebacterium glutamicum is the U.S. Patent number 4 of Sinskey etc. for example, 649,119 disclosed cloning vectors and be used for Corynebacterium glutamicum and Genetic Manipulative Technology (Yoshihama etc., the J.Bacteriol.162:591-597 (1985) of relevant tyrothricin bacterial classification (for example brevibacterium (Brevibacteriumlactofermentum)); Katsumata etc., J.Bacteriol.159:306-311 (1984); With Santamaria etc., J.Gen.Microbiol.130:2237-2246 (1984)), nucleic acid molecule then of the present invention can be used for the genetically engineered of this biology, so that it becomes the better or more effective production bacterium of one or more fine chemicals.It may be because the direct effect of genetic manipulation of the present invention causes that this fine chemicals output or production efficiency improve, and perhaps may be that the indirect effect by this generic operation causes.

SMP albumen of the present invention changes may directly influence productive rate, output and/or the production efficiency of mixing the proteic Corynebacterium glutamicum strain generation of this change fine chemicals by number of mechanisms.Such as the high-energy carbon molecular degradation of sugar and such as NADH and FADH ₂Compound be converted into the compound that contains high-energy phosphate bond by oxidative phosphorylation and can produce multiple compound, the fine chemicals that these compounds may need exactly itself is as pyruvic acid, ATP, NADH and many intermediate sugar compounds.Kinetomeres (as ATP) and reducing equivalent thing (as NADH or NADPH) that cell can utilize these pathways metabolisms to produce drive disadvantageous reaction on energy.Such adverse effect comprises many fine chemicals biosynthetic pathways.The ability of people by improving cell and utilize specific sugar (for example to coding participate in cell degradation should sugar and the gene that is translated into the enzyme of energy operate) can improve energy so that cell can carry out metabolic reaction (the synthetic fine chemicals that needs of biological example) unfavorable but that need

One or more SMP genes of the present invention of mutagenesis also may produce the SMP albumen of activity change, and the SMP albumen remote effect Corynebacterium glutamicum of activity change produces one or more needs fine chemicals.For example, people utilize one or more sugared efficient (being converted into useful kinetomeres thereby strengthen described sugar) or improve the efficient (for example by improving oxidative phosphorylation efficient or strengthening the atp synthase activity) that the reducing equivalent thing is converted into useful kinetomeres by improving Corynebacterium glutamicum, can increase these high energy compound amounts, for the common disadvantageous metabolic process of cellular driven.Such process comprise make up cell walls, transcribe, translation and essential compound (for example Nucleotide, amino acid, VITAMIN, lipid etc.) (Lengeler etc. (1999) the Biology of Prokaryotes of biosynthesizing cell growth division, Thieme Verlag:Stuttgart, 88-109,913-918,875-899 page or leaf).By growth and the breeding that improves these engineering cells, both can improve the cell viability in the large scale culturing thing, also can improve its division rate, the more substantial cell of in the fermentor cultivation thing, can surviving like this.At least because exist more generation to need the viable cell of fine chemicals and improve productive rate, output or production efficiency.In addition, cell utilizes many degraded products of sugar-fermenting process generation to need the precursor or the intermediate of product such as fine chemicals as producing other.Thereby, owing to strengthened the ability of cellular metabolism sugar, thus the degraded product quantity of using for other process of cell also can be increased.

The invention provides coding this paper and be called the proteic novel nucleic acids molecule of SMP, described SMP albumen can for example be carried out the carbohydrate metabolism that participates in Corynebacterium glutamicum such as sugar and by the function such as oxidative phosphorylation process generate energy molecule.The proteic nucleic acid molecule of coding SMP is referred to herein as the SMP nucleic acid molecule.In a preferred embodiment, described SMP albumen participation carbon molecule and degraded product thereof are converted into the energy that cell is used for metabolic process.This closes proteic example and comprises the albumen that is provided genes encoding by table 1.

Therefore, one aspect of the present invention relates to isolated nucleic acid molecule (for example cDNA, DNA or RNA), described isolated nucleic acid molecule comprises the nucleotide sequence of coding SMP albumen or its biologically-active moiety, also relates to being suitable as detecting or the primer of amplification SMP coding nucleic acid (for example DNA or mRNA) or the nucleic acid fragment of hybridization probe.In particularly preferred embodiments, described isolated nucleic acid molecule comprises coding region or its complementary sequence of one of one of nucleotide sequence described in the sequence table odd number SEQ ID NO (as SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:7...) or these nucleotide sequences.In other particularly preferred embodiment, isolated nucleic acid molecule of the present invention comprises such nucleotide sequence or its part: described nucleotide sequence and a kind of sequence table odd number SEQ ID NO (as SEQ IDNO:1, SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:7...) nucleotide sequence hybridization or have at least about 50% with it, preferably at least about 60%, more preferably at least about 70%, 80% or 90% even more preferably at least about 95%, 96%, 97%, 98%, 99% or higher homology.In other preferred embodiment, described isolated nucleic acid molecule a kind of sequence table even number SEQ ID NO (as SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ IDNO:8...) aminoacid sequence of encoding.The preferred SMP albumen of the present invention also preferably has at least a SMP activity as herein described.

In another embodiment, described isolated nucleic acid molecule encode a kind of protein or its part, wherein said albumen or its part comprise and the enough homologous aminoacid sequences of aminoacid sequence of the present invention (as having the sequence of sequence table even number SEQ ID NO), for example, make described protein or its part keep the SMP activity with the enough homologies of aminoacid sequence of the present invention.Preferably the protein of described nucleic acid molecule encoding or its part keep to carry out participate in the ability such as the carbohydrate metabolism of sugar and the function by oxidative phosphorylation process generate energy molecule (for example ATP) of Corynebacterium glutamicum.In one embodiment, by the homology of the protein of described nucleic acid molecule encoding and aminoacid sequence of the present invention (for example being selected from complete aminoacid sequence) with sequence table even number SEQ ID NO be at least about to 50%, preferably at least about 60%, more preferably at least about 70%, 80% or 90%, most preferably at least about 95%, 96%, 97%, 98% or 99% or higher.In another preferred embodiment, described protein is and complete amino acid sequence of the present invention (by the open reading-frame (ORF) as shown in the corresponding odd number SEQ of the sequence table ID NO (as SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:7...) coding) homologous total length Corynebacterium glutamicum protein basically.

In another preferred embodiment, described isolated nucleic acid molecule derives from Corynebacterium glutamicum, and coding comprises the protein (for example SMP fusion rotein) in a biologically active structure territory, described biologically active structure territory and a kind of aminoacid sequence of the present invention (for example a kind of even number SEQ ID NO sequence in the sequence table) have at least about 50% or higher homology, and can carry out carbohydrate metabolism that participates in Corynebacterium glutamicum such as sugar and the function of passing through oxidative phosphorylation process generate energy molecule (for example ATP), or having one or more activity that table 1 provides, described biologically active structure territory also comprises the heterologous nucleic acid sequence of coding heterologous polypeptide or regulatory region.

In another embodiment, described isolated nucleic acid molecule is to 15 Nucleotide of the youthful and the elderly, and under stringent condition with the making nucleic acid molecular hybridization that comprises nucleotide sequence of the present invention (for example sequence table odd number SEQ ID NO sequence).Preferred described isolated nucleic acid molecule is equivalent to naturally occurring nucleic acid molecule.More preferably described isolating nucleic acid encoding naturally occurring Corynebacterium glutamicum SMP albumen or its biologically-active moiety.

Another aspect of the present invention relates to the carrier that contains nucleic acid molecule of the present invention, and for example recombinant expression vector relates to the host cell that imports this class carrier.In one embodiment, a kind of like this host cell is used for producing SMP albumen by cultivate described host cell in suitable medium.From described substratum or described host cell, isolate described SMP albumen then.

The microorganism that relates in one aspect to the hereditary change that has wherein imported SMP gene or change SMP gene more of the present invention.In one embodiment, by importing nucleic acid molecule of the present invention, changed the genome of described microorganism as genetically modified encoding wild type or mutant SMP sequence.In another embodiment, the endogenous SMP gene in the described microbial genome is by being changed for example functional fracture with the SMP dna homolog reorganization that changes.In another embodiment, SMP gene endogenous or that introduced is changed by one or more point mutation, disappearance or inversion in the microorganism, but still encoding function SMP albumen.In an embodiment again, one or more regulatory regions of SMP gene in the microorganism (for example promotor, repressor or inductor) are changed (for example by disappearance, brachymemma, inversion or point mutation), make that described SMP expression of gene is adjusted.A preferred embodiment, described microorganism belongs to Corynebacterium or brevibacterium sp, preferred especially Corynebacterium glutamicum.In a preferred embodiment, described microorganism also is used for producing needs compound, for example amino acid, especially preferably Methionin.

On the other hand, the invention provides the method that whether has corynebacterium diphtheriae or its active situation among a kind of experimenter of evaluation.This method comprises detection intravital one or more nucleotide sequences of the present invention of experimenter or aminoacid sequence (for example sequence table SEQ ID NO 1-782 sequence), detects whether have corynebacterium diphtheriae or its active situation in the described subject thus.

Another aspect of the present invention relates to isolating SMP albumen or its part, biological example active part.In a preferred embodiment, described separation SMP albumen or its part can be carried out carbohydrate metabolism that participates in Corynebacterium glutamicum such as sugar and the function of passing through oxidative phosphorylation process generate energy molecule (for example ATP).In another preferred embodiment, the enough homologies of described isolating SMP albumen or its part and aminoacid sequence of the present invention (for example sequence table even number SEQ IDNO sequence) make described protein or its part keep and carry out carbohydrate metabolism that participates in Corynebacterium glutamicum such as sugar and the ability of passing through the function of oxidative phosphorylation process generate energy molecule (for example ATP).

The present invention also provides SMP proteic separation preparation.In preferred embodiments, described SMP albumen comprises aminoacid sequence of the present invention (for example sequence table even number SEQ ID NO sequence).In another preferred embodiment, the present invention relates to and complete amino acid sequence of the present invention (for example sequence table even number SEQ ID NO sequence) (by corresponding odd number SEQ IDNO open reading-frame (ORF) coding in the sequence table) the isolating full length protein of homologous basically.In an embodiment again, the homology of described protein and complete amino acid sequence of the present invention (for example sequence table even number SEQ IDNO sequence) is at least about to 50%, preferably at least about 60%, more preferably at least about 70%, 80% or 90%, most preferably at least about 95%, 96%, 97%, 98% or 99% or higher.In other embodiments, described isolating SMP albumen comprise with the homology of a kind of aminoacid sequence of the present invention (for example sequence table even number SEQ ID NO sequence) at least about 50% or higher aminoacid sequence, and can carry out carbohydrate metabolism that participates in Corynebacterium glutamicum such as sugar and the function of passing through oxidative phosphorylation process generate energy molecule (for example ATP), or have one or more activity that table 1 provides.

Perhaps, described isolating SMP albumen can comprise so nucleotide sequence coded aminoacid sequence: described nucleotides sequence is listed under the stringent condition and a kind of odd number SEQ IDNO nucleotide sequence hybridization in the sequence table, or with sequence table in a kind of odd number SEQ ID NO homology of nucleotide sequence at least about to 50%, preferably at least about 60%, more preferably at least about 70%, 80% or 90%, most preferably at least about 95%, 96%, 97%, 98% or 99% or higher.The also preferred proteic preferred form of SMP also has one or more SMP biological activitys described herein.

Described SMP polypeptide or its biologically-active moiety can effectively be connected with a kind of non-SMP polypeptide, form fusion rotein.In preferred embodiments, this fusion rotein has and is different from the independent proteic activity of described SMP.In other preferred embodiment, this fusion rotein is carried out carbohydrate metabolism that participates in Corynebacterium glutamicum such as sugar and the function of passing through oxidative phosphorylation process generate energy molecule (for example ATP).In particularly preferred embodiments, this fusion rotein is incorporated in the host cell, and the compound that needs of regulating described cell produces.

On the other hand, the invention provides the method that is used to screen the molecule of regulating the SMP protein-active, described molecule is by interacting with SMP albumen itself, perhaps by interacting with proteic substrate of described SMP or binding partners, perhaps, regulate the SMP protein-active by regulating transcribing or translating of SMP nucleic acid molecule of the present invention.

Another aspect of the present invention relates to the method that is used to produce fine chemicals.This method comprises cultivates the cell that comprises the carrier that instructs SMP nucleic acid molecule expression of the present invention, makes and can produce fine chemicals.In a preferred embodiment, this method comprises that also acquisition contains the step of the cell of this carrier, wherein with the carrier transfectional cell that instructs the SMP expression of nucleic acid.In another preferred embodiment, this method also comprises the step that reclaims described fine chemicals from culture.In an especially preferred embodiment, described cell derives from Corynebacterium or brevibacterium sp, or is selected from the bacterial strain described in the table 3.

Another aspect of the present invention relates to and is used to regulate the method for being given birth to tight molecule by microorganism.These class methods comprise makes described cell contact with the factor of regulating SMP protein-active or SMP protein expression, makes the cell related activity be changed for the described activity when lacking the described factor.In a preferred embodiment, regulate one or more Corynebacterium glutamicum carbon pathways metabolisms of described cell, or regulate described cell by process generate energy such as oxidative phosphorylation, make and improve productive rate or the productive rate that this microorganisms producing needs fine chemicals.The factor of regulating the SMP protein-active can be the factor that stimulates SMP protein-active or SMP expression of nucleic acid.The example of the factor of stimulation SMP protein-active or SMP expression of nucleic acid comprises small molecules, active SMP albumen and has imported the proteic nucleic acid of coding SMP of described cell.The example of the factor that suppresses the SMP activity or express comprises small molecules and antisense SMP nucleic acid molecule.

Another aspect of the present invention relates to the method that needs the compound productive rate of regulating cell, and described method comprises in wild-type or the mutant SMP gene transfered cell, perhaps is retained on the independent plasmid or is incorporated in the genome of host cell.If be incorporated in the genome, then this integration can be at random, or it can take place by homologous recombination, makes described natural gene be replaced by the copy that is imported, and the cell that causes being regulated produces the described compound that needs.In a preferred embodiment, described productive rate improves.In another preferred embodiment, described chemical is a kind of fine chemicals.In an especially preferred embodiment, described fine chemicals is a seed amino acid.In an especially preferred embodiment, described amino acid is L-Methionin.

Detailed Description Of The Invention

The invention provides SMP nucleic acid molecule and SMP protein molecular, described molecule participates in the carbon compound metabolism of Corynebacterium glutamicum such as sugar and passes through oxidative phosphorylation process generate energy molecule.Molecule of the present invention can be used to regulate for example Corynebacterium glutamicum generation fine chemicals of microorganism, this can have a direct impact, and (for example overexpression or optimization glycolytic pathway albumen are to the productive rate of for example pyruvic acid of improvement Corynebacterium glutamicum, output and/or production efficiency have a direct impact), maybe can produce remote effect, remote effect still make the productive rate that needs compound, output and/or production efficiency improve (for example regulating the energy change that the albumen that participates in oxidative phosphorylation causes finishing for cell necessary metabolic process and other cell function (as nucleic acid and protein biosynthesizing and transcribe and translate)).Below further describe all respects of the present invention.

I. fine chemicals

Term " fine chemicals " is well known in the art, comprises the molecule that has multiple application by biogenic in various industry (such as but not limited to pharmacy industry, agricultural and cosmetic industry).This compounds comprises organic acid, for example tartrate, methylene-succinic acid and diaminopimelic acid; The proteinic amino acid of proteinogenous and non-formation; Purine and pyrimidine bases, nucleosides and Nucleotide (as being described in for example Kuninaka, A. (1996) Nucleotide and related compound are stated from Biotechnology, the 6th volume, the 561-612 page or leaf, Rehm etc. write, VCH:Weinheim and the reference that wherein contains); Lipid, saturated and unsaturated fatty acids (for example arachidonic acid); Dibasic alcohol (for example propylene glycol and butyleneglycol); Carbohydrate (for example hyaluronic acid and trehalose); Aromatic substance (for example aromatic amine, Vanillin and indigo); VITAMIN and cofactor (as are described in Ullmann ' s Encyclopedia of Industrial Chemistry, A27 volume, " VITAMIN ", 443-613 page or leaf (1996) VCH:Weinheim and reference wherein; And Ong, A.S., Niki, E. and Packer, L. (1995) " Nutrition; Lipids, Health, and Disease " Proceedings of the UNESCO/Confederation of Scientific and TechnologicalAssociations in Malaysia, and the Society for Free Radical Research-Asia, hold AOCS Press, (1995) at Malaysian Penang in 1-3 day in September, 1994); Enzyme; Polyketide (Cane etc. (1998) Science 282:63-68); And Gutcho (1983) Chemicals by Fermentation, Noyes Data Corporation, all other compounds that ISBN:0818805086 and reference are wherein introduced.Some metabolism and application in these fine chemicals below is described in further detail.

A. amino acid metabolism and application

Amino acid is the basic structural unit of all proteins, is that all biological normal cell functions are requisite therefore.Term " amino acid " is known in the art.Forming proteinic amino acid has 20 kinds, and as proteinic structural unit, they connect by peptide bond in protein; Usually be not present in (referring to Ulmann ' s Encyclopedia of Industrial Chemitry, A2 volume, 57-97 page or leaf VCH:Weinheim (1985)) in the protein but not form proteinic amino acid (known hundreds of institutes reach amino acid).Amino acid can have D-or L-optical configuration, though L-amino acid generally is the unique type of finding in the naturally occurring protein.20 kinds form each biosynthesizing and the degradation pathway of proteinic amino acid in prokaryotic cell prokaryocyte and eukaryotic cell and fully characterize (referring to for example Stryer, L.Biochemistry, the 3rd edition, 578-590 page or leaf (1988))." essential " amino acid (Histidine, Isoleucine, leucine, Methionin, methionine(Met), phenylalanine, Threonine, tryptophane and Xie Ansuan) is name so, be because their biosynthesizing complexity, generally be to need in the nutrition, described " essential " amino acid is converted into all the other 11 kinds of " nonessential " amino acid (L-Ala, arginine, l-asparagine, aspartic acid, halfcystine, L-glutamic acid, glutamine, glycine, proline(Pro), Serine and tyrosine) by simple biosynthetic pathway easily.Higher animal has kept some the amino acid whose ability in synthetic these amino acid really, but indispensable amino acid must supply from diet, so that carry out normal protein synthesis.

Except the function of these amino acid in the protein biosynthesizing, these amino acid self still are interesting chemical, have been found that wherein many amino acid have various uses in foodstuffs industry, fodder industry, chemical industry, cosmetic industry, agricultural and pharmacy industry.Methionin is not only the important amino acid of human nutrition, and is the important amino acid of monogastric animal (for example poultry and pig) nutrition.L-glutamic acid is the most frequently used to be made odor control additive (monosodium glutamate MSG), and is extensive use of in foodstuffs industry, and aspartic acid, phenylalanine, glycine and halfcystine also are like this.Glycine, L-methionine(Met) and tryptophane all are used for pharmacy industry.Glutamine, Xie Ansuan, leucine, Isoleucine, Histidine, arginine, proline(Pro), Serine and L-Ala are valuable on pharmacy industry and cosmetic industry.Threonine, tryptophane and D/L-methionine(Met) are the fodder additivess of using always.(Leuchtenberger, W. (1996) amino acid-production technology and application are stated from (writing) Biotechnology such as Rehm, the 6th volume, the 14a chapter, the 466-502 page or leaf, VCH:Weinheim).In addition, have been found that these amino acid can be used as synthetic synthesizing amino acid and proteinic precursor, for example N-acetylcystein, S-carboxymethyl-L-halfcystine, (S)-5-hydroxytryptophan and Ulmann ' s Encyclopedia of IndustrialChemistry, the A2 volume, the 57-97 page or leaf, VCH:Weinheim, other synthesizing amino acid and the protein introduced in 1985.

Fully characterized the biosynthesizing of these amino acid in can produce these natural amino acid whose biologies (for example bacterium) (the synthetic and summary of regulating of relevant bacterium amino acid bio referring to Umbarger, H.E. (1978) Ann.Rev.Biochem.47:533-606).By the synthetic L-glutamic acid of the reductive amination of the intermediate α-Tong Wuersuan in the tricarboxylic acid cycle.Produce glutamine, proline(Pro) and arginine respectively by L-glutamic acid subsequently.The biosynthesizing of Serine is one three step process, with 3-phoshoglyceric acid (glycolysis-intermediate) beginning, behind oxidation, transamination and hydrolysing step, produces this seed amino acid.Halfcystine and glycine are all produced by Serine, and the former produces by homocysteine and Serine condensation, and the latter produces by in the catalytic reaction side chain beta carbon being transferred to tetrahydrofolic acid (THFA) by serine transhydroxymethylase at one.Phenylalanine and tyrosine are synthetic by the 9 step biosynthetic pathways that glycolysis-and pentose-phosphate pathway precursor erythrose-4-phosphate and phosphoenolpyruvic acid begin, and the biosynthetic pathway of this two seed amino acid is the latter two steps difference behind synthetic prephenic acid instead.Tryptophane is also produced by these two kinds of starting molecules, but its synthetic be one 11 step approach.Tyrosine also can be synthetic by phenylalanine in the catalytic reaction by Phenylalanine hydroxylase at one.L-Ala, Xie Ansuan and leucine all are the biosynthetic products of glycolysis-end product-pyruvic acid.Aspartic acid is generated by the intermediate oxaloacetic acid of tricarboxylic acid cycle.L-asparagine, methionine(Met), Threonine and Methionin all are that the conversion by aspartic acid produces.Isoleucine is generated by Threonine.9 step approach of a complexity are that ribose 5-phosphate-1-tetra-sodium produces Histidine by a kind of activation sugar.

The amino acid that exceeds the synthetic demand of cell protein can not be stored, but is degraded, and (relevant summary is referring to Stryer for the main metabolic pathway of cell provides intermediate, L.Biochemistry, the 3rd edition, the 21st chapter, " amino acid degradation and ornithine cycle ", 495-516 page or leaf (1988)).Though cell can be converted into unwanted amino acid in useful metabolism intermediate, with regard to the necessary enzyme of energy, precursor molecule and synthesizing amino acid, amino acid production is expensive.Therefore, amino acid bio is synthetic, and to be subjected to feedback inhibition be N/R, in feedback inhibition, the existence of specific amino acids play a part to slow down or stop fully himself producing (summary of the Feedback mechanism in the relevant amino acid biosynthetic pathway, referring to Stryer, L.Biochemistry, the 3rd edition, the 24th chapter, " biosynthesizing of amino acid and protoheme ", 575-600 page or leaf (1988).Therefore, the output of any specific amino acids is subjected to the amino acid quantitative limitation that exists in the cell.

B. the metabolism of VITAMIN, cofactor and nutritional drugs and application

VITAMIN, cofactor and nutritional drugs constitute other component that higher animal has been lost synthesis capability and therefore must take in, and for example bacterium is synthetic but they are easily by other biology.These molecules or itself are biologically active substances, or can be as the precursor as the biologically active substance of the intermediate of electron carrier or multiple pathways metabolism.These compounds are except having nutritive value, and the essential industry that also has as tinting material, antioxidant and catalyzer or other processing aid is worth.(about the general introduction of structure, activity and the industrial application of these compounds, referring to for example Ullman ' s Encyclopedia of Industrial Chemistry, " VITAMIN ", A27 volume, 443-613 page or leaf, VCH:Weinheim, 1996).Term " VITAMIN " is well known in the art, comprise biological normal function needs but biological self can not the synthetic nutrition.Vitamins can comprise cofactor and nutritional drugs compound.Term " cofactor " comprises the active required non-albumen compound of generation normal enzyme.This compounds can be organic compound or mineral compound; Cofactor molecule of the present invention is organic molecule preferably.Term " nutritional drugs " is included in the foodstuff additive that have health advantages among plant and animal, the particularly mankind.The example of this quasi-molecule is VITAMIN, antioxidant and some lipid (for example polyunsaturated fatty acid).

Characterized in a large number these molecules for example biosynthesizing in the bacterium of the biology that can produce it (Ullman ' s Encyclopedia of Industrial Chemistry, A27 volume, " VITAMIN " 443-613 page or leaf, VCH:Weinheim, 1996; Michal, G. (1999) Biochemical Pathways:An Atlas of Biochemistry and Molecular Biology, John Wiley ﹠amp; Sons; Ong, A.S., Niki, E. and Packer, L. (1995) " Nutrition, Lipids, Health; and Disease " Proceedings of the UNESCO/Confederationof Scientific and Technological Associations in Malaysia, and the Societyfor Free Radical Research-Asia holds AOCS Press:Champaign in 1-3 day in September, 1994 at Malaysian Penang, IL X, 374S).

By with pyrimidine and the chemical coupling of thiazole part, sternly give birth to VitB1 (vitamins B ₁).Riboflavin (vitamins B ₂) synthetic by guanosine-5 '-triphosphoric acid (GTP) and ribose-5 '-phosphoric acid.Riboflavin and then be used for synthetic vitamin B2 phosphate (FMN) and flavin adenine dinucleotide (FAD).Be referred to as " vitamins B ₆" compound family (for example pyridoxine hydrochloride of pyridoxol, Pyridoxylamine, pyridoxal-5 '-phosphoric acid and commercial use) all be derivative with common structure unit 5-hydroxyl-6-picoline.Pantothenic acid ((R)-(+)-N-(2,4-dihydroxyl-3,3-dimethyl-1-oxo butyl)-Beta-alanine) can or pass through fermentative production by chemosynthesis.Last step in the pantothenic acid biosynthesizing is made up of Beta-alanine and pantoic acid condensation that ATP drives.The enzyme of being responsible for being converted into pantoic acid, Beta-alanine and condensation and being the biosynthesizing step of pantothenic acid is known.The pantothenic acid of metabolic activity form is coenzyme A, and its biosynthesizing is carried out with 5 enzymatic steps.Pantothenic acid, pyridoxal-5 '-phosphoric acid, halfcystine and ATP are the precursors of coenzyme A.These enzymes are the generation of catalysis pantothenic acid not only, and catalysis (R)-pantoic acid, (R)-pantolacton, (R)-panthenol (provitamin B ₅), the generation of pantetheine (and derivative) and coenzyme A.

Study the vitamin H biosynthesizing that begins by precursor molecule pimeloyl coenzyme A in the microorganism in great detail, and identified related some genes.It is synthetic to have been found that many corresponding proteins matter also participate in iron bunch, and is the member of nifS proteinoid.Thioctic Acid is derived from sad, and as the coenzyme in the energy metabolism, it becomes the part of pyruvate dehydrogenase complex and ketoglurate dehydrogenase complex body in energy metabolism.The folic acid class is the material of a class folic acid derivatives, and folic acid is again derived from L-L-glutamic acid, para-amino benzoic acid and 6-methylpterin.At length studied the biosynthesizing of folic acid and derivative thereof in certain micro-organisms, described biosynthesizing originates in metabolism intermediate guanosine-5 '-triphosphoric acid (GTP), L-L-glutamic acid and para-amino benzoic acid.

Corrinoid (for example cobalami, particularly vitamins B ₁₂) and porphyrin belong to the chemical substance that a category feature is the tetrapyrrole ring system.Vitamins B ₁₂Biosynthesizing enough complicated so that do not identified fully as yet, but known many related enzymes and substrate now.Nicotinic acid and niacinamide are pyridine derivates, are also referred to as " nicotinic acid ".Nicotinic acid is the important coenzyme NAD (Reduced nicotinamide-adenine dinucleotide) and the precursor of NADP (Triphosphopyridine nucleotide, reduced) and reduction form thereof.

The scale operation of these compounds mainly relies on acellular chemosynthesis always.Although some in these chemical also produced by extensive microorganism culturing, for example riboflavin, vitamins B ₆, pantothenic acid and vitamin H.Vitamins B only ₁₂Because its synthetic complicacy is passed through fermentative production.In vitro method spends big content of starting materials and time, and ordinary expenditure is huge.

C. the metabolism of purine, pyrimidine, nucleosides and Nucleotide and application

Purine and pyrimidine metabolic gene and corresponding proteins matter thereof are the important treatment targets of tumor disease and virus infection.Term " purine " or " pyrimidine " comprise nitrogenous base, and they are components of nucleic acid, coenzyme and Nucleotide.Term " Nucleotide " comprises the basic structural unit of nucleic acid molecule, they by a nitrogenous base, (under the situation of RNA, described sugar is ribose to a pentose; Under the situation of DNA, described sugar is the D-ribodesose) and the phosphoric acid formation.Term " nucleosides " comprises the molecule that is used as nucleotide precursor but lacks the phosphoric acid part that Nucleotide had.By biosynthesizing that suppresses these molecules or the conversion that suppresses its formation nucleic acid molecule, might suppress the synthetic of RNA and DNA; Suppress this activity by mode, the ability that can suppress tumour cell division and duplicate with target cancer cell.In addition, have and do not form nucleic acid molecule but as energy storage (being AMP) or as the Nucleotide of coenzyme (being FAD and NAD).

Several publications have been described by influencing purine and/or pyrimidine metabolic, these chemical substances are used for these medical science indications (Christopherson for example, R.I. and Lyons, S.D. (1990) " as pyrimidine and from the beginning biosynthetic effective inhibitor of purine of chemotherapeutic ", Med.Res.Reviews 10:505-548).The research of the enzyme that participates in purine and pyrimidine metabolic is concentrated on always can be as for example as the exploitation (Smith of the new drug of immunosuppressor or antiproliferative agents, J.L., (1995) " enzyme during Nucleotide is synthetic ", Curr.Opin.Struct.Biol.5:752-757; (1995) Biochem Soc.Transact.23:877-902).Yet, purine and pyrimidine bases, nucleosides and Nucleotide have other purposes: be used as the biosynthetic intermediate of several fine chemicals (for example VitB1, S-adenosine-methionine(Met), folic acid or riboflavin), be used as the energy carrier (for example ATP or GTP) of cell and be used for chemical self, usually be used as odorant (for example IMP or GMP) or be used for some medicinal uses (referring to for example Kuninaka, A. (1996) Nucleotides andRelated Compounds in Biotechnology. the 6th rolls up, Rehm etc. write, VCH:Weinheim; The 561-612 page or leaf).In addition, the enzyme that participates in purine, pyrimidine, nucleosides or nucleotide metabolism is used for the target of the chemical of cover crop more and more as exploitation, and described chemical comprises mycocide, weedicide and sterilant.

(relevant summary is referring to for example Zalkin to have identified the metabolism of these compounds in bacterium, H. and Dixon, J.E. (1992) " from the beginning biosynthesizing of purine nucleotides ", be stated from: Progress in Nucleic Acid Research and Molecular Biology, the 42nd volume, Academic Press, the 259-287 page or leaf; And Michal, G. (1999) " Nucleotide and nucleosides " is stated from: Biochemical Pathways:An Atlas of Biochemistry and MolecularBiology, the 8th chapter, Wiley: New York).Purine metabolism is the theme of broad research always, and is absolutely necessary for the normal function of cell.Purine metabolism is impaired in higher animal can cause serious disease, for example gout.Purine nucleotides is begun to synthesize by ribose-5-phosphoric acid, series of steps by midbody compound inosine-5 '-phosphoric acid (IMP), cause the generation of guanosine-5 '-a phosphoric acid (GMP) or adenosine-5 '-a phosphoric acid (AMP), generate the triphosphoric acid form that is used as Nucleotide easily by GMP or AMP.These compounds are also as the energy storage thing, so its many different Biochemical processes that are degraded in the cell provide energy.The pyrimidine biosynthesizing is undertaken by forming uridylic-5 '-a phosphoric acid (UMP) by ribose-5-phosphoric acid.UMP so be converted into Cytidine-5 '-triphosphoric acid (CTP).The deoxidation form of all these Nucleotide produced in the reduction reaction in a step, was the bisphosphate ribodesose form of described Nucleotide from the bisphosphate ribose form reduction reaction of described Nucleotide.After phosphorylation, it is synthetic that these molecules can participate in DNA.

D. the metabolism of trehalose and application

Trehalose is by with α, α-1, and two molecule glucoses that 1-connects are formed.Trehalose usually as sweeting agent, promptly is used for a kind of additive of desiccating food products or frozen product and beverage in foodstuffs industry.Yet it also has many application (referring to for example Nishimoto etc., (1998) U.S. Patent number 5,759,610 in pharmacy industry, cosmetic industry and biotechnological industries; Singer, M.A. and Lindquist, S. (1998) Trends Biotech.16:460-467; Paiva, C.L.A. and Panek, AD. (1996) Biotech.Ann.Rev.2:293-314; And Shiosaka, M. (1997) J.Japan 172:97-102).Trehalose is produced by enzyme by many microorganisms, and natural being discharged in the surrounding medium, can collect trehalose from described surrounding medium with methods known in the art.

II. the utilization and the oxidative phosphorylation of sugar and carbon molecule

Carbon is the important element that forms all organic compound, so it is not only Corynebacterium glutamicum growth splitted nutritional requirement, and is the nutritional requirement of the excessive generation fine chemicals of this microorganism.Carbohydrate such as monose, disaccharide or polysaccharide is good especially carbon source, so the standard growth substratum contains one or more following sugar usually: glucose, fructose, seminose, semi-lactosi, ribose, sorbose, ribulose, lactose, maltose, sucrose, raffinose, starch or Mierocrystalline cellulose (Ullmann ' s Encyclopedia of Industrial Chemistry (1987) A9 volume, " enzyme ", VCH:Weinheim).On the other hand, more compound sugar can be used for described substratum, for example other byproduct in molasses or the sugar refining.Described sugar other compound in addition carbon source as an alternative be can use, alcohols (for example ethanol or methyl alcohol), paraffinic, sugar alcohol, lipid acid and organic acid (for example acetic acid or lactic acid) comprised.About carbon source and culturing micro-organisms summary to their utilization, referring to: Ullman ' s Encyclopedia of Industrial Chemistry (1987) A9 volume, " enzyme ", VCH:Weinheim; Stoppok, E. and Buchholz, K. (1996) " the sugared type raw material that fermentation is used " is stated from: Biotechnology (Rehm, H.J. writes) the 6th volume, VCH:Weinheim, 5-29 page or leaf; Rehm, H.J. (1980) IndustrielleMikrobiologie, Springer:Berlin; Bartholomew, W.H. and Reiman, H.B. (1979), zymotechnique economics is stated from: Peppler, H.J. and Perlman, D. writes, Microbial Technology the 2nd edition, the 2nd volume, the 18th chapter, Academic Press: New York; And Kockova-Kratachvilova, the feature of A. (1981) industrial microorganism is stated from: Rehm, and H.J. and Reed, G. writes, Handbook of Biotechnology, the 1st volume, the 1st chapter, Verlag Chemie:Weiheim.

After these carbon molecular absorption that are rich in energy are gone into cell, must carry out processing treatment, it can be degraded by a kind of main carbohydrate metabolism approach.This approach directly produces useful degraded product, for example ribose 5-phosphate and phosphoenolpyruvic acid, and phosphoenolpyruvic acid can be converted into pyruvic acid subsequently.3 kinds of most important bacterium carbohydrate metabolism approach comprise Embden-Meyerhoff-Pamas (EMP) approach (being also referred to as glycolytic pathway or hexose diphosphate approach), (summary is referring to Michal for hexose monophosphoric acid (HMP) approach (being also referred to as pentose shunt approach or phosphopentose pathway) and Entner-Doudoroff (ED) approach, G. (1999) Biochemical Pathways:An Atlas ofBiochemistry and Molecualr Biology, Wiley: New York and Stryer, L. (1988) Biochemistry, the 13-19 chapter, Freeman: New York, and the reference of wherein quoting).

EMP Embden Meyerbof Parnas pathway makes the hexose molecule be converted into pyruvic acid, and this process produces 2 molecule ATP and 2 molecule NADH.With Cori ester (can directly absorb from substratum, perhaps can be produced by glycogen, starch or Mierocrystalline cellulose) is raw material, makes the glucose molecule isomery turn to fructose-6-phosphate, makes its phosphorylation, is cracked into 2 three carbon molecule glyceraldehyde-3-phosphates.In dehydrogenation, phosphorylation with after resetting continuously, obtain pyruvic acid.

It is reducing equivalent thing such as NADPH that the HMP approach makes conversion of glucose, and produces pentose and tetrose compound, and they are necessary intermediate and precursors of many other pathways metabolisms.In the HMP approach, G-6-P is converted into ribulose-5-phosphoric acid by 2 continuous dehydrogenation enzyme reactions (it also discharges 2 molecule NADPH) and 1 carboxylated step.Ribulose-5-phosphoric acid also can be converted into xylulose-5-phosphoric acid and ribose-5-phosphoric acid; The former can be converted into G-6-P through a series of biochemical steps, and G-6-P can enter EMP Embden Meyerbof Parnas pathway, and the latter is used as the intermediate of its biosynthetic pathway of cell usually.

The ED approach begins with compound glucose or glyconic acid, and it is phosphorylation and dehydrogenation formation 2-dehydrogenation-3-deoxidation-6-P-glyconic acid subsequently.Glucuronic acid and galacturonic acid also can be converted into 2-dehydrogenation-3-deoxidation-6-P-glyconic acid by more complicated biochemical route.This product molecule is cracked into Glycerose-3-P and pyruvic acid subsequently; Glycerose-3-P itself also can be converted into pyruvic acid.

EMP and HMP approach have many features, comprise intermediate and enzyme.EMP Embden Meyerbof Parnas pathway provides ATP amount at most, but it does not produce ribose-5-phosphoric acid, and ribose-5-phosphoric acid is biological nucleic acid synthetic important as precursors for example, does not also produce E4P, and erythrose is synthetic to amino acid bio to be important.Therefore can only utilize the microorganism of glucose EMP Embden Meyerbof Parnas pathway on the simple culture media of glucose, not grow as sole carbon source.This microorganism is called fastidious microorganism, and its growth needs adds organochromium compound, for example sees the organochromium compound of yeast extract.

On the contrary, the HMP approach produces nucleic acid and synthetic the two the essential whole precursor of amino acid bio, but only produces half ATP energy of EMP Embden Meyerbof Parnas pathway.The HMP approach also produces NADPH, and NADPH can be used for the reduction reaction of biosynthetic pathway.Yet the HMP approach does not directly produce pyruvic acid, so these microorganisms also must have this part of EMP Embden Meyerbof Parnas pathway.So countless microorganisms, especially facultative anaerobe are evolved and have this two kinds of approach, this is not unexpected.

The ED approach only sees bacterium at present.Although this approach is relevant with people HMP approach part on the opposite direction that precursor forms, the ED approach directly forms pyruvate salt by zymohexase cracking 3-ketone group deoxidation-6-phosphogluconic acid.The ED approach can independently exist, for most of strictly anaerobic Institute of Micro-biology utilizes.Net result is similar to the HMP approach, but has only when carbon atom is converted into pyruvate salt rather than precursor molecule, just produces 1 mole of ATP.

The pyruvate molecules that produces by above arbitrary approach can be converted into energy by Krebs circulation (being also referred to as tricarboxylic acid cycle, tricarboxylic acid cycle or tricarboxylic acid cycle (TCA circulation)) at an easy rate.In the Krebs circulation, at first pyruvic acid decarboxylation produces 1 molecule NADH, 1 molecule acetyl-CoA and 1 molecule carbonic acid gas.The ethanoyl of acetyl-CoA subsequently with the reaction of the oxaloacetic acid (oxaolacetate) of 4 carbosilane units, form 6 carbon organic acid citric acids.Dehydration and discharge 2 molecule carbonic acid gas again.At last, produce oxaloacetic acid again and can be used as the ethanoyl acceptor again, so far finish circulation.The transfer transport that intermediate oxidation in the TCA circulation discharges is given NAD ⁺, produce NADH.

In the respiratory, the NADH transfer transport is given oxygen molecule or other terminal electron acceptor.This process is by respiratory chain catalysis, and respiratory chain is the electron transport system that comprises integral protein and embrane-associated protein.There are two basic roles in this system: the first, and accept the electronics of electron donor and it is transferred to electron acceptor(EA), the second, preserve the portion of energy that transfer transport discharges by synthetic ATP.Known some kinds of oxydo-reductase and electron transport albumen participate in this process, comprise nadh dehydrogenase, contain flavine electron carrier, iron-sulphur protein and cytopigment.Nadh dehydrogenase is positioned at the kytoplasm face of plasma membrane, and it is transferred to flavoprotein with hydrogen atom from NADH, accepts the electronics of NADH then.Flavoprotein is one group of electron carrier with flavine prothetic group, alternately reduction and oxidation when its acceptance and metastatic electron.Known 3 kinds of flavine participate in these reactions: riboflavin, flavine-adenine dinucleotide (FAD) and vitamin B2 phosphate (FMN).Iron-sulphur protein contains cluster iron atom and sulphur atom, they not with the protoheme bonding, but still can participate in dehydration and rehydration is reacted.Succinodehydrogenase and aconitase are typical iron-sulphur proteins; Its iron-sulfur complex plays a part to accept and metastatic electron as the integral part of whole electron transport chain.Cytopigment are the albumen that contains iron porphyrin ring (protoheme).Many dissimilar cytopigment are arranged, their reduction potential difference.On function, these cytopigment constitute the approach that electronics wherein can be transferred to other cytopigment that positive reduction potential constantly increases progressively.The non-albumen electron carrier of known other type has: fat-soluble quinone (for example ubiquinone).These molecules also play hydrogen atom acceptor and electron donor.

Respiratory chain plays a role and produces the cross-cell membrane proton gradient, produces proton motive force.Cell utilizes this power by striding the synthetic ATP of film enzyme atp synthase.The ATP enzyme is a kind of mixture of polyprotein, wherein Molecule subunit's physical property rotation in cell membrane transporter makes cell, be accompanied by the ADP phosphorylation form ATP (summary is referring to Fillingame, R.H. and Divall, S. (1999) Novartis Found.Symp.221:218-229,229-234).

Non-hexose carbon substrate also can be as the carbon source and the energy source of cell.This substrate at first is converted into the hexose of gluconeogenesis approach, cell synthesis of glucose at first wherein, the generate energy of degrading then.The raw material of this reaction is phosphoenolpyruvic acid (PEP), and phosphoenolpyruvic acid is a kind of important intermediate of glycolytic pathway.PEP can be formed by the substrate beyond the sugar, and for example acetic acid perhaps forms by oxaloacetic acid (this is as TCA round-robin intermediate) decarboxylation.Reverse glycolytic pathway (utilization is different from the cascade enzyme of original glycolytic pathway) and can form G-6-P.Pyruvic acid is converted into glucose need utilize 6 high-energy phosphate bonds, and glycolysis-is that pyruvic acid only produces 2 ATP with conversion of glucose.Yet, glucose complete oxidation (glycolysis-, pyruvic acid are converted into acetyl-CoA, tricarboxylic acid cycle and oxidative phosphorylation) produces 36-38 ATP, the high-energy phosphate bond that carries out the gluconeogenesis net loss like this produces such high-energy phosphate bond and increase generally by oxidizing glucose, thereby is compensated.

III. element of the present invention and method

The present invention to small part based on having found that this paper is called the novel molecular of SMP nucleic acid and protein molecular, the sugar that described SMP molecule participates in Corynebacterium glutamicum is converted into useful degraded product and energy (for example ATP), perhaps produces the useful molecule that is rich in energy (for example ATP) by other process such as oxidative phosphorylation.In one embodiment, the SMP molecule participates in the carbon compound metabolism of Corynebacterium glutamicum such as sugar and by the process generate energy molecule (for example ATP) such as oxidative phosphorylation.In a preferred embodiment, participating in Corynebacterium glutamicum carbon metabolism and energy-producing SMP molecular activity of the present invention needs fine chemicals to exert an influence to this biology generation.In an especially preferred embodiment, regulate the activity of SMP molecule of the present invention, the Corynebacterium glutamicum pathways metabolism and the energy path that make SMP albumen of the present invention participate in are regulated on productive rate, output and/or production efficiency, this directly or the indirect regulation Corynebacterium glutamicum produce productive rate, output and/or the production efficiency that needs fine chemicals.

Term " SMP albumen " or " SMP polypeptide " comprise can carry out the carbohydrate metabolism that participates in Corynebacterium glutamicum such as sugar and by the protein such as the energy-producing function of process of oxidative phosphorylation.SMP albumen example comprises the protein of the SMP genes encoding that is provided by table 1 and by odd number SEQ ID NO encoded protein matter.Term " SMP gene " or " SMP nucleotide sequence " comprise coding SMP proteic nucleotide sequence, and this nucleotide sequence is made up of a coding region and corresponding untranslated 5 ' and 3 ' sequence area.The proteic example of SMP comprises the albumen that table 1 provides.Term " output " or " throughput " are well known in the art, are included in tunning (for example the needing fine chemicals) concentration that obtains in preset time and the given fermentation volume (for example per hour every liter kg product).Term " production efficiency " comprises the required time of specific production level that reaches (for example how long cell reaches specific fine chemicals output capacity needs).Term " productive rate " or " product/carbon productive rate " are well known in the art, comprise that carbon source is converted into the efficient of product (being fine chemicals).This is typically expressed as the kg product of for example every kg carbon source.By productive rate or the output that increases described compound, can increase recovery molecular amounts or the efficient recovery molecular amounts of this compound in preset time, specified rate culture.Term " biosynthesizing " or " biosynthetic pathway " are well known in the art, comprise cell with may be that multistep is rapid, the process of altitude mixture control begins synthetic compound, organic compound preferably from midbody compound.Term " degraded " or " degradation pathway " are well known in the art, comprise cell with may be that multistep is rapid, the process of altitude mixture control is with compound, preferably organic compound is decomposed into degraded product (molecule that generally speaking, be less or complexity is lower).Term " degraded product " is well known in the art, comprises the degradation production of compound.Described product itself may be as essential precursor (starting point) or intermediate molecule when cell biological synthesizes other compound.Term " metabolism " is well known in the art, comprises biological esoteric all biological chemical reaction.The metabolism of the specific compound amino acid whose metabolism of glycine (for example such as) comprises then that all biological relevant with this compound in the cell is synthetic, modification and degradation pathway.

In another embodiment, SMP molecule of the present invention can be regulated microorganism for example needs for example generation of fine chemicals of molecule in the Corynebacterium glutamicum.SMP albumen of the present invention changes may directly influence productive rate, output and/or the production efficiency of mixing the proteic Corynebacterium glutamicum strain generation of this change fine chemicals by number of mechanisms.Degraded high-energy carbon molecule is as sugar and make compound such as NADH and FADH2 be converted into more useful form by oxidative phosphorylation can to produce chemical compound lot, the fine chemicals that these compounds may need exactly itself, for example pyruvic acid, ATP, NADH and multiple intermediate sugar compounds.And then kinetomeres (as ATP) and reducing equivalent thing (as NADH or NADPH) that cell can utilize these pathways metabolisms to produce drive disadvantageous reaction on energy.Such adverse effect comprises many fine chemicals biosynthetic pathways.People utilize the ability (for example the operation coding participates in described cell degradation and transforms the gene that this sugar is the enzyme of energy) of specific sugar can improve energy by the improvement cell, so that cell can carry out metabolic reaction (biological example synthesizes needs fine chemicals) unfavorable but that need

One or more SMP genes of the present invention of mutagenesis also may produce the SMP albumen of activity change, and the SMP albumen remote effect Corynebacterium glutamicum of activity change produces one or more needs fine chemicals.For example, people can increase these high energy compound amounts by the efficient (for example by improving oxidative phosphorylation efficient or strengthening the atp synthase activity) that raising utilizes one or more sugared efficient (being converted into useful kinetomeres thereby strengthen described sugar) or raising reducing equivalent thing to be converted into useful kinetomeres, for the common disadvantageous metabolic process of cellular driven.Such process comprise make up cell walls, transcribe, translation and essential compound (for example Nucleotide, amino acid, VITAMIN, lipid etc.) (Lengeler etc. (1999) the Biologyof Prokaryotes of biosynthesizing cell growth division, Thieme Verlag:Stuttgart, 88-109,913-918,875-899 page or leaf).By growth and the breeding that improves these engineering cells, both can improve the cell viability in the large scale culturing thing, also can improve its division rate, more substantial like this cell can be survived in the fermentor cultivation thing.At least improve productive rate, output or production efficiency because there being the viable cell of the required fine chemicals of more generation.In addition, a large amount of degradeds of carbohydrate metabolism generation and midbody compound are the essential precursor and the intermediate of whole other biosynthetic pathway of cell.For example many amino acid directly synthesize (for example Serine is synthetic by glycolysis-intermediate 3-phoshoglyceric acid) by common generation from glycolysis-or TCA round-robin compound.Thereby, by having strengthened the sugared efficient that is converted into the useful energy molecule, also can increase useful degraded product quantity.

Isolated nucleic acid sequences of the present invention is included in the genome of Corynebacterium glutamicum strain, and described bacterial strain can obtain by American type culture collection, and preserving number is ATCC13032.The proteic predicted amino acid sequence of the nucleotide sequence of described isolating Corynebacterium glutamicum SMP DNA and Corynebacterium glutamicum SMP is shown in respectively among sequence table odd number SEQ ID NO and the even number SEQ ID NO.Carry out Computer Analysis, with the classification of these nucleotide sequences and/or be accredited as that coding has the carbon compound metabolism that participates in Corynebacterium glutamicum such as sugar and by proteinic sequence such as the function of the process generate energy molecule of oxidative phosphorylation.

The present invention also relates to the amino acid that had and aminoacid sequence of the present invention (for example sequence table even number SEQ ID NO sequence) homologous protein basically.Aminoacid sequence that has used herein and selected aminoacid sequence be homologous protein basically, with selected aminoacid sequence (for example described complete selected aminoacid sequence) at least about 50% homology.Aminoacid sequence that is had and selected aminoacid sequence be homologous protein basically, also can with selected aminoacid sequence have at least about 50-60%, preferably at least about 60-70%, more preferably at least about 70-80%, 80-90% or 90-95%, most preferably at least about 96%, 97%, 98%, 99% or higher homology.

SMP albumen of the present invention or its biologically-active moiety or fragment can participate in the carbon compound metabolism of Corynebacterium glutamicum such as sugar and by such as the process generate energy molecule (for example ATP) of oxidative phosphorylation, or have one or more activity that table 1 provides.

All respects of the present invention are described in following trifle in further detail.

A. isolated nucleic acid molecule

One aspect of the present invention relates to the isolated nucleic acid molecule of coding SMP polypeptide or its biologically-active moiety and is suitable as to be identified or the hybridization probe of amplification SMP coding nucleic acid (for example SMP DNA) or the nucleic acid fragment of primer.Term used herein " nucleic acid molecule " will be meant DNA or the RNA analogue that comprises dna molecular (for example cDNA or genomic dna) and RNA molecule (for example mRNA) and employing nucleotide analog deposits yields.This term also comprises the non-translated sequence that is positioned at gene coding region 3 ' end and 5 ' end: the sequence and the gene coding region 3 ' at least about 100 Nucleotide of 5 ' end upstream, coding region are held the sequence of downstream at least about 20 Nucleotide.Described nucleic acid molecule can be strand or two strands, but double-stranded DNA preferably." isolating " nucleic acid molecule be with described nucleic acid natural origin in other nucleic acid molecule isolated nucleic acid molecule of existing.Preferably " isolating " nucleic acid molecule does not contain the sequence (promptly being positioned at the sequence of described nucleic acid 5 ' end and 3 ' end) of the described nucleic acid of natural adjacency in the biological genomic dna in described nucleic acid source.For example, in various embodiments, isolating SMP nucleic acid molecule can contain the nucleotide sequence of nucleic acid molecule as described in the natural adjacency in the genomic dna of the cell (as the Corynebacterium glutamicum cell) in described nucleic acid source less than about 5kb, 4kb, 3kb, 2kb, 1kb, 0.5kb or 0.1kb.In addition, " isolating " nucleic acid molecule, for example dna molecular can be substantially free of other cellular material, does not maybe contain substratum when cultivating by recombinant technology, or do not contain precursor or other chemical substance when chemosynthesis.

Nucleic acid molecule of the present invention (nucleic acid molecule that for example has sequence table odd number SEQ ID NO nucleotide sequence) or its part can learn a skill with standard biological and separate with sequence information provided herein.For example, can be with the full sequence of one of sequence table odd number SEQ ID NO sequence or partial sequence as hybridization probe, (for example adopt with the standard hybridization technique, be described in the technology of following document: Sambrook, J., Fritsh, E.F. and Maniatis, T.Molecular Cloning:ALaboratory Manual. the 2nd edition, Cold Spring Harbor Laboratory, Cold SpringHarbor Laboratory Press, Cold Spring Harbor, NY, 1989), from the Corynebacterium glutamicum library, isolate Corynebacterium glutamicum SMP DNA.In addition, the nucleic acid molecule that comprises all or part of sequence of one of nucleotide sequence of the present invention (for example odd number SEQ ID NO), can adopt Oligonucleolide primers based on this sequences Design, by the polymerase chain reaction separate (nucleic acid molecule that for example, comprises all or part of sequence of one of nucleotide sequence of the present invention (as sequence table odd number SEQ ID NO) can adopt based on as described in the Oligonucleolide primers of design of sequence separate by the polymerase chain reaction).For example, can be from normal endotheliocyte separating mRNA (for example by (1979) Biochemistry 18:5294-5299 such as Chirgwin guanidine thiocyanate extraction method), (for example Moloney MLV ThermoScript II can derive from Gibco/BRL to use ThermoScript II then, Bethesda, MD; Or the AMV ThermoScript II, can derive from Seikagaku America, Inc., St.Petersburg, FL) preparation DNA.Can be designed for the synthetic oligonucleotide primer thing of polymerase chain reaction (PCR) amplification based on one of nucleotide sequence shown in the sequence table.As template, with suitable Oligonucleolide primers, according to Standard PC R amplification technique, nucleic acid of the present invention can increase with cDNA or genomic dna.The nucleic acid clone of so amplification in suitable carriers, and is identified by dna sequence analysis.In addition, can pass through the standard synthetic technology, for example prepare with automatic dna synthesizer corresponding to the oligonucleotide of SMP nucleotide sequence.

In a preferred embodiment, isolated nucleic acid molecule of the present invention comprises the nucleotide sequence shown in a kind of sequence table.Nucleotide sequence of the present invention shown in the sequence table is equivalent to Corynebacterium glutamicum SMP DNA of the present invention.This DNA comprises the coding proteic sequence of SMP (being " coding region " shown in each odd number SEQ ID NO of sequence table) and 5 ' non-translated sequence and 3 ' non-translated sequence, and described non-translated sequence also is shown among the sequence table odd number SEQ ID NO.Perhaps, described nucleic acid molecule can only comprise the coding region of the arbitrary nucleotide sequence of sequence table.

In order to carry out this application, people know, every kind of nucleotide sequence shown in the sequence table and aminoacid sequence have sign property RXA, RXN or RXS numbering, meet identifier RXA, RXN or the RXS (being RXA01626, RXN00043 or RXS0735) of 5 bit digital after described numbering has.Every kind of described nucleotide sequence comprises three parts at the most: one 5 ' upstream, a coding region and a catchment.Each district in these three districts differentiates by identical RXA, RXN or RXS identifier, to avoid confusion.Narration " one of sequence table odd number sequence " then is meant the arbitrary nucleotide sequence of sequence table, and it also can be distinguished according to its different RXA, RXN or RXS identifier.The coding region of each sequence in these sequences is translated into amino acid sequence corresponding, and described aminoacid sequence also is shown in the sequence table, as being right after corresponding nucleic sequence even number SEQ ID NO afterwards.For example, the coding region of RXA02735 is shown among the SEQ ID NO:1, and its amino acid sequence coded is shown among the SEQ ID NO:2.The sequence of nucleic acid molecule of the present invention is differentiated according to RXA, RXN or the RXS identifier identical with their coded amino acid moleculars, makes and can easily they be interrelated.For example, the aminoacid sequence of RXA00042 by name is the nucleotide sequence coded district translation of RXA00042 nucleic acid molecule.Corresponding relation between RXA, RXN and RXS nucleotide sequence and aminoacid sequence and its specified SEQ ID NO sees Table 1.

Some genes of the present invention are " F marker gene ".The F marker gene comprises the gene that had " F " before the RXA identifier shown in the table 1.For example, the SEQ ID NO:11 of as shown in table 1 being called " F RXA01312 " is a kind of F marker gene, and SEQ ID NO:29,33 and 39 (being called " F RXA02803 " in table 1, " F RXA02854 ", " FRXA01365 ") also is like this.

In one embodiment, nucleic acid molecule of the present invention does not comprise the nucleic acid molecule of table 2 inediting.With regard to the dapD gene, the sequence of this gene is published in Wehrmann, A. etc. (1998) J.Bacteriol.180 (12): among the 3159-3165.Yet the sequence that the present application people obtains significantly is longer than the form of being announced.Think that described announcement form is because of incorrect initiator codon, therefore only represents a fragment of true coding region.

In another preferred embodiment, isolated nucleic acid molecule of the present invention comprises nucleic acid molecule or its part of the complementary sequence of a kind of nucleotide sequence of the present invention (for example sequence table odd number SEQ ID NO sequence).With a kind of complementary nucleic acid molecule of nucleotide sequence of the present invention be with one of nucleotide sequence shown in the sequence table (odd number SEQ ID NO for example: sequence) enough complementary, make and can and therefore form the nucleic acid molecule of stablizing duplex with the hybridization of one of nucleotide sequence of the present invention.

In a preferred embodiment again, isolated nucleic acid molecule of the present invention comprises such nucleotide sequence or its part: the homology of described nucleotide sequence and nucleotide sequence of the present invention (for example sequence table odd number SEQ ID NO sequence) is at least about 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59% or 60%, preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69% or 70%, more preferably at least about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79% or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89% or 90%, or 91%, 92%, 93%, 94%, even more preferably at least about 95%, 96%, 97%, 98%, 99% or higher.The present invention also comprises the scope and sign numerical value (for example 70-90% is identical or 80-95% identical) between the above-mentioned numerical value.For example, comprise the above-mentioned value that adopts any combination ident value scope as the upper limit and/or lower limit.In another preferred embodiment, isolated nucleic acid molecule of the present invention comprises nucleotide sequence or its part with the hybridization of one of nucleotide sequence of the present invention, for example hybridize under stringent condition.

In addition, nucleic acid molecule of the present invention can only comprise the part in a kind of odd number SEQ IDNO sequence encoding district in the sequence table, for example can be as the fragment of probe or primer or the fragment of the proteic biologically-active moiety of coding SMP.According to the nucleotide sequence of measuring from Corynebacterium glutamicum clone SMP gene, make the probe or the primer of the SMP homologue that can prepare the SMP homologue that is used for identifying and/or clone other cell type or biology and other excellent bacillus or relevant bacterial classification.Described probe/primer comprises the oligonucleotide of basic purifying usually.Described oligonucleotide comprises a kind of nucleotide sequence district usually, described nucleotide sequence district under stringent condition with the antisense sequences of one of the sense strand of one of nucleotide sequence of the present invention (as sequence table odd number SEQ ID NO sequence), these sequences or its naturally occurring mutant at least about 12, preferred about 25, more preferably from about 40,50 or 75 continuous nucleotides hybridization.Primer based on nucleotide sequence of the present invention can be used for the PCR reaction, with clone SMP homologue.Can be used for detecting the transcript or the genome sequence of same albumen of coding or homologous protein based on the probe of described SMP nucleotide sequence.In preferred embodiments, described probe also comprises a connected labelling groups, and for example described labelling groups can be radio isotope, fluorescent chemicals, enzyme or enzyme cofactor.This class probe can be as the part of diagnostic test test kit, to identify the proteic cell of unconventionality expression SMP, for example by measuring the level of SMP coding nucleic acid in the cell sample, for example detect SMP mRNA level or detect genome SMP gene and whether suddenly change or lack.

In one embodiment, nucleic acid molecule encoding of the present invention is a kind of to comprise protein or its part with the enough homologous aminoacid sequences of aminoacid sequence of the present invention (for example sequence table even number SEQ ID NO sequence), the carbon compound metabolism that makes described protein or its part keep to participate in Corynebacterium glutamicum such as sugar and by the ability such as the process generate energy molecule (for example ATP) of oxidative phosphorylation.Term used herein " enough homology " is meant a kind of like this protein or its part: described protein or the aminoacid sequence that its part had comprise the identical with aminoacid sequence of the present invention of minimal number or are equal to (for example similar amino-acid residue of amino-acid residue in the side chain that is had and the sequence table even number SEQID NO sequence) amino-acid residue, make described protein or its part can participate in the carbon compound metabolism of Corynebacterium glutamicum such as sugar and pass through process generate energy molecule (for example ATP) such as oxidative phosphorylation.The albumen member of this class carbohydrate metabolism approach as herein described or energy production system may worked aspect the production of one or more fine chemicals and the secretion.The active example of this class has also been described in this article.Therefore, " the proteic function of SMP " influences productive rate, output and/or the production efficiency of one or more fine chemicals directly or indirectly.SMP protein-active example sees Table 1.

In another embodiment, the homology of described protein and complete amino acid sequence of the present invention (for example sequence table even number SEQ ID NO sequence) is at least about 50-60%, preferably at least about 60-70%, more preferably at least about 70-80%, 80-90%, 90-95%, most preferably at least about 96%, 97%, 98%, 99% or higher.

The proteic biologically-active moiety of preferably a kind of described SMP of proteinic part that SMP nucleic acid molecule of the present invention is coded.Term used herein " the proteic biologically-active moiety of SMP " comprises the carbon compound metabolism that participates in Corynebacterium glutamicum such as sugar and the proteic part of SMP of production capacity approach, structural domain/motif for example, or have a kind of activity that table 1 provides.In order to determine that whether SMP albumen or its biologically-active moiety can participate in the metabolism of Corynebacterium glutamicum carbon compound and produce the molecule that is rich in energy, can carry out the mensuration of enzymic activity.This class measuring method is that those skilled in the art are well-known, as what describe in detail among the embodiment 8 of embodiment part.

Be prepared as follows the nucleic acid fragment of other coding SMP protein biological activity part: a part of separating a kind of aminoacid sequence of the present invention (for example sequence table even number SEQ ID NO sequence), express the encoding part (for example passing through in-vitro recombination expression) of described SMP albumen or peptide, and estimate the activity of the encoding part of described SMP albumen or peptide.

The present invention comprises that also the degeneracy owing to genetic code is different from a kind of nucleotide sequence of the present invention (for example sequence table odd number SEQ ID NO sequence) (with its part) and the SMP proteic nucleic acid molecule identical with the coded albumen of nucleotide sequence of the present invention of therefore encoding.In another embodiment, the nucleotide sequence coded protein that isolated nucleic acid molecule of the present invention had with aminoacid sequence shown in the sequence table (for example even number SEQ ID NO).In an embodiment again, nucleic acid molecule encoding of the present invention and aminoacid sequence of the present invention (by the coding of the open reading-frame (ORF) shown in the sequence table odd number SEQID NO) be homologous total length Corynebacterium glutamicum albumen basically.

One skilled in the art will appreciate that in one embodiment sequence of the present invention does not comprise the sequence of prior art, for example the Genbank sequence shown in the table 2 or 4 that before the present invention, just obtains.In one embodiment, the present invention includes the identity per-cent that has with nucleotide sequence of the present invention or aminoacid sequence nucleotide sequence and aminoacid sequence greater than the identity per-cent of the sequence of prior art (for example Genbank sequence of narration in the table 2 or 4 protein of this sequence encoding (or by)).For example, the present invention includes: with the identity of the nucleotide sequence of RXA00014 by name (SEQ IDNO:41) greater than 58% and/or be at least 58% nucleotide sequence; With the identity of the nucleotide sequence of RXA00195 by name (SEQ ID NO:399) greater than % and/or be at least the nucleotide sequence of %; And with the identity of the nucleotide sequence of RXA00196 by name (SEQ ID NO:401) greater than 42% and/or be at least 42% nucleotide sequence.Those skilled in the art are by detecting the identity fractions that the GAP shown in the highest table 4 that hits each of three of any given sequences of the present invention calculates, and deduct the identity per-cent that the highest GAP calculates with 100%, can calculate the lower limit of described given sequence identity per-cent of the present invention.Those skilled in the art also can know, the present invention comprises that also identity per-cent is greater than the lower limit that so calculates (for example at least 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59% or 60%, preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69% or 70%, more preferably at least about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79% or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89% or 90%, or 91%, 92%, 93%, 94%, even more preferably at least about 95%, 96%, 97%, 98%, 99% or higher) nucleotide sequence and aminoacid sequence.

Except the Corynebacterium glutamicum SMP nucleotide sequence shown in the sequence table odd number SEQ ID NO, one skilled in the art will appreciate that in colony (for example Corynebacterium glutamicum colony), to have the dna sequence polymorphism that causes SMP Argine Monohydrochloride sequence to change.Because natural variation, the genetic polymorphism in the described SMP gene of this class may be present in the individuality of colony.Term used herein " gene " and " recombination " are meant and comprise coding SMP albumen, the nucleic acid molecule of the proteic open reading-frame (ORF) of Corynebacterium glutamicum SMP preferably.This class natural variation causes the variation of 1-5% in the described SMP gene nucleotide series usually.Because the result of natural variation and do not change active any or all this class nucleotide diversity of SMP protein function and the amino acid polymorphism that produced is included in the scope of the present invention.

According to the natural variation body that is equivalent to Corynebacterium glutamicum SMP DNA of the present invention and the nucleic acid molecule of non-glutamic acid rod bacillus homologue and the homology of Corynebacterium glutamicum SMP nucleic acid disclosed herein, adopt described Corynebacterium glutamicum DNA or its part as hybridization probe under stringent hybridization condition according to the standard hybridization technique, can isolate described nucleic acid molecule.Therefore, in another embodiment, at least 15 Nucleotide of isolated nucleic acid molecule of the present invention are long, and under stringent condition with comprise the making nucleic acid molecular hybridization of sequence table odd number SEQ ID NO nucleotide sequence.In one embodiment, the length of described nucleic acid is at least 30,50,100,250 or more a plurality of Nucleotide.Term used herein " hybridize under stringent condition " is intended to describe hybridization and the wash conditions that at least 60% homologous nucleotide sequence each other keeps the phase mutual cross usually.Preferably described condition make each other homology be at least about 65%, more preferably at least about 70% in addition more preferably at least about 75% or higher sequence keep the phase mutual cross usually.This class stringent condition is well known by persons skilled in the art, and can be at Ausubel etc., Current Protocols in Molecular Biology, John Wiley ﹠amp; Sons, N.Y. (1989) finds among the 6.3.1-6.3.6.A preferred limiting examples of stringent hybridization condition be in 6X sodium chloride/sodium citrate (SSC) in about 45 ℃ of hybridization, then at 0.2XSSC, carry out one or many washing in 50-65 ℃ among the 0.1%SDS.Preferably under stringent condition, be equivalent to naturally occurring nucleic acid molecule with the isolated nucleic acid molecule of the present invention of nucleotide sequence hybridization of the present invention." naturally occurring " used herein nucleic acid molecule is meant the have naturally occurring nucleotide sequence RNA or the dna molecular of (natural protein of for example encoding).In one embodiment, a kind of natural Corynebacterium glutamicum SMP albumen of described nucleic acid encoding.

Except the naturally occurring varient of the described SMP sequence that in colony, may exist, those skilled in the art also know, can import change by in nucleotide sequence of the present invention, suddenling change, cause the proteic aminoacid sequence of coded SMP to change thus, and do not change the proteic Functional Capability of described SMP.For example, can in Nucleotide of the present invention, cause replacing at the Nucleotide of " nonessential " amino-acid residue upper amino acid replacement." nonessential " amino-acid residue is can be changed in the proteic wild-type sequence of described SMP (for example sequence table even number SEQID NO) and do not change the residue of described SMP protein-active, and " essential " amino-acid residue is SMP protein-active needs.Yet other amino-acid residue (for example conservative or only semiconservative residue in having SMP active structures territory) may not be active essential, therefore may be fit to change and does not change the SMP activity.

Therefore, another aspect of the present invention relates to the proteic nucleic acid molecule of coding SMP, and the active non-essential amino acid residue of the proteic SMP of described SMP changes.This class SMP albumen is different from sequence table even number SEQ ID NO sequence on aminoacid sequence, but still keeps at least a SMP activity as herein described.In one embodiment, described isolated nucleic acid molecule comprises the nucleotide sequence of coded protein, wherein said protein comprise with aminoacid sequence of the present invention at least about 50% homologous aminoacid sequence, and can participate in the carbon compound metabolism and the biosynthesizing high energy compound of Corynebacterium glutamicum such as sugar, or have one or more activity that table 1 provides.Preferably in the protein of described nucleic acid molecule encoding and the sequence table a kind of even number SEQ IDNO aminoacid sequence at least about the 50-60% homology, more preferably with one of these sequences at least about the 60-70% homology, more preferably with one of these sequences at least about 70-80%, 80-90%, 90-95% homology, most preferably with a kind of aminoacid sequence of the present invention at least about 96%, 97%, 98% or 99% homology.

In order to determine the percent homology of two seed amino acid sequences (for example a kind of aminoacid sequence of the present invention and its mutant) or two kinds of nucleic acid, carry out best sequence contrast (for example can introduce the room) relatively to carry out the optimal sequence contrast with another kind of protein or nucleic acid in the sequence of a kind of protein or nucleic acid.More corresponding then amino acid position or nucleotide position upper amino acid residue or Nucleotide.When a position in the sequence (as a kind of aminoacid sequence of the present invention) was occupied by the same amino-acid residue of corresponding position in another sequence (mutant of aminoacid sequence for example) or Nucleotide, then described two kinds of molecules were homologous (being that amino acid used herein or nucleic acid " homology " are equal to amino acid or nucleic acid " identity ") in this position.Percent homology between these two sequences is the function (being percent homology=same position number/total number of positions * 100) that described sequence is shared the same position number.

Coding can make up by following steps with protein sequence of the present invention (for example sequence table even number SEQ ID NO sequence) the proteic isolated nucleic acid molecule of homologous SMP: in nucleotide sequence of the present invention, import one or more Nucleotide and replace, add or disappearance, make in coded protein, to import one or more aminoacid replacement, interpolation or disappearance.Can adopt standard technique, for example sudden change of site-directed mutagenesis and PCR mediation, will suddenly change imports in a kind of nucleotide sequence of the present invention.Preferably carrying out conserved amino acid on the non-essential amino acid residue of one or more predictions replaces." conserved amino acid replacement " is the aminoacid replacement that wherein said amino-acid residue is had the amino-acid residue replacement of similar side chain.Determined to have the amino-acid residue classification of similar side chain in the art.These classifications comprise amino acid with basic side chain (Methionin for example, arginine, Histidine), amino acid (aspartic acid for example with acid side-chain, L-glutamic acid), amino acid (glycine for example with uncharged polar side chain, l-asparagine, glutamine, Serine, Threonine, tyrosine, halfcystine), amino acid (L-Ala for example with non-polar sidechain, Xie Ansuan, leucine, Isoleucine, proline(Pro), phenylalanine, methionine(Met), tryptophane), amino acid (Threonine for example with β-branched building block, Xie Ansuan, Isoleucine) and amino acid (tyrosine for example with aromatic side chains, phenylalanine, tryptophane, Histidine).Therefore, the non-essential amino acid residue of predicting in the SMP albumen is preferably replaced by the another kind of amino-acid residue from same side chain classification.Perhaps, in another embodiment, can import sudden change at random, for example import sudden change by saturation mutagenesis along all or part SMP encoding sequence, and can screen the mutant that is produced according to SMP activity as herein described, keep the active mutant of SMP to identify.After the nucleotide sequence mutagenesis to one of sequence table odd number SEQ ID NO, can recombinant expressed coded protein, can adopt mensuration for example as herein described (referring to the embodiment 8 of embodiment part) to measure described activity of proteins then.

Except the proteic nucleic acid molecule of above-mentioned coding SMP, another aspect of the present invention relates to the isolated nucleic acid molecule of antisense." antisense " nucleic acid comprises " justice is arranged " nucleic acid complementary nucleotide sequence with coded protein, for example with the coding strand of double-stranded DNA complementary or with mRNA sequence complementary nucleotide sequence.Therefore, antisense nucleic acid can form hydrogen bond with phosphorothioate odn is arranged.Described antisense nucleic acid and complete SMP coding strand or only with its part complementation.In one embodiment, antisense nucleic acid molecule is the antisense nucleic acid molecule of " coding region " of the proteic nucleotide sequence coded chain of coding SMP.Term " coding region " is meant the nucleotide sequence district (for example the complete coding region of SEQ ID NO:3 (RXA01626) comprises Nucleotide 1-345) that comprises the codon that is translated into amino-acid residue.In another embodiment, described antisense nucleic acid molecule is the antisense nucleic acid molecule of the nucleotide sequence coded chain " non-coding region " of coding SMP.Term " non-coding region " is meant in abutting connection with described coding region, is not translated into amino acid whose 5 ' sequence and 3 ' sequence (promptly being also referred to as 5 ' and 3 ' non-translational region).

The coding strand sequence (for example sequence shown in the sequence table odd number SEQ IDNO) of known coding SMP disclosed herein therefore can design antisense nucleic acid of the present invention according to Waston and Crick basepairing rule.Described antisense nucleic acid molecule can with the complete coding region complementation of SMP mRNA, but only be more preferably oligonucleotide with a part of antisense of SMP mRNA coding region or non-coding region.For example, described antisense oligonucleotide can with SMP mRNA translation initiation site around the section complementation.For example, described antisense oligonucleotide can for example about 5,10,15,20,25,30,35,40,45 or 50 Nucleotide long.The enzyme ligation that can adopt chemosynthesis and adopt methods known in the art makes up antisense nucleic acid of the present invention.For example, can synthesize antisense nucleic acid (as antisense oligonucleotide) with the Nucleotide chemistry of naturally occurring Nucleotide or various modifications, the Nucleotide design of described modification is in order to increase described molecular biology stability or to increase described antisense nucleic acid and formed duplex physical stability between the phosphorothioate odn is arranged, the Nucleotide that for example can use thiophosphoric acid derivative and acridine to replace.The example of Nucleotide that can be used for producing the modification of described antisense nucleic acid comprises 5 FU 5 fluorouracil, 5-bromouracil, the 5-chlorouracil, 5-iodouracil, xanthoglobulin, xanthine, the 4-acetylcytosine, 5-(carboxyl hydroxymethyl) uridylic, 5-carboxymethylamino methyl-2-thio uridine, 5-carboxymethylamino 6-Methyl Uracil, dihydrouracil, β-D-galactosyl Q nucleosides (queosine), inosine, the N6-isopentenyl gland purine, the 1-methyl guanine, the 1-methylinosine, 2, the 2-dimethylguanine, the 2-methyladenine, the 2-methyl guanine, the 3-methylcystein, 5-methylcytosine, the N6-VITAMIN B4, the 7-methyl guanine, 5-methylamino 6-Methyl Uracil, 5-methoxyl group amino methyl-2-thiouracil, β-D-mannose group Q nucleosides, 5 '-methoxyl group carboxyl 6-Methyl Uracil, the 5-methoxyuracil, 2-methylthio group-N6-isopentenyl gland purine, uridylic-the 5-oxyacetic acid (v), wybutoxosine, pseudouracil, the Q nucleosides, 2-sulfo-cytosine(Cyt), 5-methyl-2-thiouracil, the 2-thiouracil, the 4-thiouracil, methyl uracil, uridylic-5-hydroxy methyl acetate, uridylic-the 5-oxyacetic acid (v), 5-methyl-2-thiouracil, 3-(3-amino-3-N-2-carboxylic propyl group) uridylic, (acp3) w and 2,6-diaminopurine.On the other hand, can adopt with the antisense orientation subclone a kind of nucleic acid (promptly the RNA that goes out by the transcribed nucleic acid that is inserted will have the antisense orientation of interested target nucleic acid, in following trifle, further describe) expression vector, produce described antisense nucleic acid with biological method.

Usually give cell with antisense nucleic acid molecule of the present invention or its original position is produced, make them with the hybridization of the coding proteic cell mRNA of SMP and/or genomic dna or combine, to suppress described proteic expression thus, for example transcribe and/or translate and suppress to express by inhibition.Can hybridize by the Nucleotide complementarity of routine, forming stable duplex, or for example with the situation of DNA duplex bonded antisense nucleic acid molecule under, interact by the specificity in the duplex tap drain and to hybridize.Can modify described antisense molecule, make it, and be incorporated into the acceptor or the antigen of selected cell surface expression specifically for example by making described antisense nucleic acid molecule and be incorporated into cell surface receptor or antigenic peptide or antibody and be connected.Can described antisense nucleic acid molecule be passed to cell with carrier described herein.In order to obtain the described antisense molecule of enough intracellular concentrations, preferred wherein said antisense nucleic acid molecule places the vector construct under strong prokaryotic organism, virus or the promoter in eukaryote control.

In an embodiment again, antisense nucleic acid molecule of the present invention is a α-different nucleic acid molecule.α-different nucleic acid molecule and complementary RNA form specific double-stranded crossbred, and be wherein opposite with common β unit, described chain (Gaultier etc. (1987) Nucleic Acids.Res.15:6625-6641) parallel to each other.Described antisense nucleic acid molecule also can comprise 2 '-o-methyl ribonucleotides (Inoue etc. (1987) Nucleic Acids Res.15:6131-6148) or chimeric RNA-DNA analogue (Inoue etc. (1987) FEBS Lett.215:327-330).

In yet another embodiment, antisense nucleic acid of the present invention is a kind of ribozyme.Ribozyme is the catalytic RNA molecule with rnase, and they can cut the single-chain nucleic acid that has complementary district with it, for example mRNA.Therefore, can (for example hammerhead ribozyme (being described in Haselhoff and Gerlach (1988) Nature 334:585-591) comes catalyze cleavage SMP mRNA transcript, suppresses the translation of SMP mRNA thus with ribozyme.Can (be SEQ ID NO.3 (RXA01626), design has specific ribozyme to the SMP coding nucleic acid according to the nucleotide sequence of SMP cDNA disclosed herein.For example, make up the derivative of a kind of tetrahymena (Tetrahymena) L-19 IVSRNA, wherein nucleotide sequence complementation to be cut among the nucleotide sequence of reactive site and the SMP coding mRNA.U.S. Patent number 5,116,742 referring to the U.S. Patent number 4,987,071 of for example Cech etc. and Cech etc.Perhaps, can use SMP mRNA, from the RNA library of molecules, select to have the active catalytic RNA of particular core ribonuclease T..Referring to for example Bartel, D. and Szostak, J.W. (1993) Science 261:1411-1418.

On the other hand, by target and SMP Nucleotide regulatory region (for example SMP promotor and/or enhanser) complementary nucleotide sequence,, can suppress the SMP expression of gene to form the triple-helix structure that stops SMP genetic transcription in the target cell.Generally referring to Helene, C. (1991) Anticancer Drug Des.6 (6): 569-84; Helene, C. etc. (1992) Ann.N.Y.Acad.Sci.660:27-36; And Maher, L.J. (1992) Bioassays 14 (12): 807-15.

B. recombinant expression vector and host cell

Another aspect of the present invention relates to the carrier of the nucleic acid that contains coding SMP albumen (or its part), preferred expression carrier.Term used herein " carrier " is meant the nucleic acid molecule that can transport connected another kind of nucleic acid.One type carrier is " plasmid ", and plasmid is meant the circular double stranded DNA ring that wherein can connect other DNA section.The carrier of another kind of type is a virus vector, wherein other DNA section can be connected in the viral genome.Some carrier can be in the host cell that they imported self-replicating (bacteria carrier and the additive type Mammals carrier that for example have the bacterium replication orgin).Other carrier (for example non-add type Mammals carrier) is incorporated into after importing to host cell in the genome of host cell, therefore duplicates with host genome.In addition, some carrier can instruct and its expression of gene that effectively is connected.This class carrier is referred to herein as " expression vector ", and generally speaking, the expression vector that uses in recombinant DNA technology is the carrier of plasmid form normally.In this manual, " plasmid " and " carrier " can exchange use, because plasmid is the carrier format that uses most.Yet, the present invention includes the expression vector of this other form of class, virus vector (for example replication defect type retrovirus, adenovirus and adeno associated virus) for example, the function that their performances are equal to.

Recombinant expression vector of the present invention comprises the nucleic acid of the present invention that is suitable for expressing the form of nucleic acid of the present invention in host cell, this is meant that described recombinant expression vector comprises one or more adjusting sequences of selecting according to the host cell that is used to express, and described adjusting sequence effectively is connected in nucleotide sequence to be expressed.In recombinant expression vector, " effectively connecting " is meant the interested nucleotide sequence of institute is connected in described adjusting sequence in the mode that allows described nucleotide sequence to express (for example in in-vitro transcription/translation system maybe when with described carrier importing host cell in described host cell).Term " adjusting sequence " comprises promotor, enhanser and other expression controlling elements (for example polyadenylation signal).This class is regulated sequence description in for example Goeddel; Gene Expression Technology:Methods in Enzymology 185, AcademicPress, San Diego, CA (1990).Regulate sequence and be included in the adjusting sequence that instructs the adjusting sequence of nucleotide sequence constitutive expression in many type host cells and only in some host cell, instruct described nucleotide sequence to express.The preferred sequence of regulating is for example promotor, for example cos-, tac-, trp-, tet-, trp-tet, lpp-, lac-, lpp-lac, lacI ^q, T7-, T5-, T3-, gal-, trc-, ara-, SP6-, amy, SPO2, λ-P _R-or λ P _L, they are preferred in the bacterium.Other regulates sequence is for example promotor of yeast and fungi, for example ADC1, MF α, AC, P-60, CYC1, GAPDH, TEF, rp28, ADH; Plant promoter, for example CaMV/35S, SSU, OCS, lib4, usp, STLS1, B33, no or ubiquitin promotor or phaseolin promoter.Also can use artificial promotor.The factor of selection such as host cell to be transformed, the proteic expression level of needs etc. is depended in the design that one skilled in the art will appreciate that described expression vector.Expression vector of the present invention can be imported in the host cell, produce protein or peptide thus, comprise fusion rotein or peptide (for example the SMP albumen of SMP albumen, mutant form, fusion rotein etc.) by nucleic acid encoding as herein described.

Can design recombinant expression vector of the present invention is used for expressing SMP albumen at prokaryotic cell prokaryocyte or eukaryotic cell.For example, can in following cell, express the SMP gene: bacterial cell for example Corynebacterium glutamicum, insect cell (use rhabdovirus expression vector), yeast and other fungal cell (referring to Romanos, M.A. etc. (1992) " exogenous gene expression in the yeast: summary ", Yeast 8:423-488; Van den Hondel, C.A.M.J.J. etc. (1991) " allogeneic gene expression in filamentous fungus ", be stated from: More Gene Manipulations in Fungi, J.W.Bennet and L.L.Lasure write, the 396-428 page or leaf: Academic Press:San Diego; With van den Hondel, C.A.M.J.J. and Punt, P.J. (1991), " be used for the exploitation of gene transfer system and the carrier of filamentous fungus ", be stated from: Applied Molecular Genetics of Fungi, Peberdy, J.F. wait and write, the 1-28 page or leaf, Cambridge University Press:Cambridge), algae and metaphyte cell are (referring to Schmidt, L. (1988) " Arabidopis thaliana (Arabidopsis thaliana) of efficient agrobacterium tumefaciens (Agrobacterium tumefaciens) mediation and the conversion of cotyledon explant " Plant Cell Rep.:583-586) or mammalian cell R. and Willmitzer.Proper host cell is at Goeddel, Gene ExpressionTechnology:Methods in Enzymology 185, and Academic Press, San Diego, CA has further description in (1990).Perhaps, described recombinant expression vector can for example transcribe and translate with T7 promotor adjusting sequence and T7 polysaccharase external.

Expressing protein is the most frequently used in prokaryotic organism contains the composing type that instructs fusion rotein or non-expressing fusion protein or the carrier of inducible promoter carries out.Fusion vector adds to a plurality of amino acid on the wherein coded albumen, adds to the N-terminal of described recombinant protein usually, but also adds to C-terminal, or merges in the suitable district in described protein.This class fusion vector has three effects usually: 1) increase Recombinant Protein Expression; 2) solvability of the described recombinant protein of increase; With 3) by help the purifying of described recombinant protein as the part in the affinity purification.Usually, in fusion expression vector, introduce a proteolytic enzyme cutting site at the contact place of merging part and recombinant protein, so that can behind the described fusion rotein of purifying, recombinant protein be separated with fusion portion.This fermentoid and relevant recognition sequence thereof comprise factor Xa, zymoplasm and enteropeptidase.

Typical fusion expression vector comprises pGEX (Pharmacia Biotech Inc; Smith, D.B. and Johnson, K.S. pMAL (New EnglandBiolabs (1988) Gene 67:31-40),, Beverly, MA) and pRIT5 (Pharmacia, Piscataway, NJ), they respectively with glutathione S-transferase (GST), maltose E is conjugated protein or A albumen and target recombinant protein merge.In one embodiment, the proteic encoding sequence of described SMP is cloned in the pGEX expression vector, to produce the carrier of encoding fusion protein, described fusion rotein comprises GST-zymoplasm cleavage site-X protein from N-terminal to C-terminal.Described fusion rotein can pass through affinitive layer purification with gsh-agarose resin.The reorganization SMP albumen with the GST fusion can not reclaim by cut described fusion rotein with zymoplasm.

The example of the non-fusion coli expression carrier of suitable induction type comprises pTrc (Amann etc., (1988) Gene 69:301-315), pLG338, pACYC184, pBR322, pUC18, pUC19, pKC30, pRep4, pHS1, pHS2, pPLc236, pMBL24, pLG200, pUR290, pIN-III113-B1, λ gt11, pBdC1 and pET11d (Studier etc., GeneExpression Technology:Methods in Enzymology 185, Academic Press, SanDiego, California (1990) 60-89; Write (1985) Cloning Vectors.Elsevier with Pouwels etc.: New York IBSN 0 444 904018).PTrc carrier target gene expression depends on the host RNA polysaccharase of hybrid trp-lac promoter, fusion and transcribes.The target gene expression of pET11d carrier depends on transcribing of viral rna polymerase (T7 gn1) T7 gn10-lac promoter, fusion by co expression.This varial polymerases is by host strain BL21 (DE3) or HMS174 (DE3) supply of residence (resident) the λ prophage that contains the T7 gn1 gene under the control of lacUV5 promoter transcription.About the conversion of other bacterium mutation, can select suitable carriers.For example, known plasmid pIJ101, pIJ364, pIJ702 and pIJ361 can be used for transforming streptomyces (Streptomyces), and plasmid pUB110, pC194 or pBD214 are applicable to that transforming bacillus belongs to (Bacillus) bacterial classification.Several plasmids that are used for genetic information is transferred to Corynebacterium comprise pHM1519, pBL1, pSA77 or pAJ667 (Pouwels etc. write (1985) CloningVectors.Elsevier: New York IBSN 0,444 904018).

Making the maximized a kind of strategy of expression of recombinant proteins is to express described albumen (Gottesman in the impaired host bacteria of the described recombinant protein ability of proteolytic cleavage, S., GeneExpression Technology:Methods in Enzymology 185, Academic Press, SanDiego, California (1990) 119-128).Another kind of strategy is to change the nucleotide sequence that is inserted into the nucleic acid in the expression vector, makes that each amino acid whose each codon is at the preferential codon (Wada etc. (1992) Nucieic Acids Res.20:2111-2118) that uses of the selected bacterium (for example Corynebacterium glutamicum) that is used for expressing.The change of this nucleotide sequence of the present invention can be carried out with the standard DNA synthetic technology.

In another embodiment, described SMP protein expression vector is a kind of Yeast expression carrier.The example that is used for the carrier of expressing at yeast yeast saccharomyces cerevisiae (S.cerevisiae) comprises pYepSec1 (Baldari etc. (1987) Embo J.6:229-234), 2 μ, pAG-1, Yep6, Yep13, pEMBLYe23, pMFa (Kurjan and Herskowitz (1982) Cell 30:933-943), pJRY88 (Schultz etc., Gene 54:113-123) and pYES2 (InvitrogenCorporation (1987), San Diego, CA).Be applicable to other fungi for example carrier and the carrier construction method of filamentous fungus be included in carrier and the method that describes in detail in the following document: van den Hondel, C.A.M.J.J. and Punt, P.J. (1991) " are used for the exploitation of gene transfer system and the carrier of filamentous fungus ", be stated from: Applied Molecular Genetics of Fungi, J.F.Peberdy etc. write, the 1-28 page or leaf, Cambridge University Press:Cambridge and Pouwels etc. write (1985) Cloning Vectors.Elsevier: New York (IBSN 0,444 904018).

On the other hand, SMP albumen of the present invention can be with rhabdovirus expression vector in expressed in insect cells.The baculovirus vector that is used in the middle expressing protein of insect cell (for example Sf9 cell) of cultivation comprises pAc series (Smith etc. (1983) Mol.Cell Biol.3:2156-2165) and pVL series (Lucklow and Summers (1989) Virology 170:31-39).

In another embodiment, SMP albumen of the present invention can be expressed at one-celled plants cell (for example algae) or in the vegetable cell of higher plant (for example spermatophyte, such as crop).The example of plant expression vector comprises the expression vector that is specified in the following document: Becker, D., Kemper, E., Schell, J. and Masterson, R. (1992) " near the novel plant binary vector that has selective marker on the left circle ", Plant Mol.Biol.20:1195-1197; And Bevan, M.W. (1984) " the double base agrobacterium vector that is used for Plant Transformation ", Nucl.Acid.Res.12:8711-8721, and comprise that (Pouwels etc. write (1985) Cloning Vectors.Elsevier: New York IBSN 0444904018) for pLGV23, pGHlac+, pBIN19, pAK2004 and pDH51.

In an embodiment again, nucleic acid of the present invention is expressed in mammalian cell with mammalian expression vector.The example of mammalian expression vector comprises pCDM8 (Seed, B. (1987) Nature 329:840) and pMT2PC (Kaufman etc. (1987) EMBO J.6:187-195).When being used for mammalian cell, the controlled function of described expression vector is provided by viral regulatory element usually.For example, Chang Yong promotor derives from polyomavirus, adenovirus 2, cytomegalovirus and simian virus 40.For being used for prokaryotic cell prokaryocyte and eukaryotic other appropriate expression system, referring to Sambrook, J., Fritsh, E.F. and Maniatis, the 16th and 17 chapters that T.Molecular Cloning:ALaboratory Manual. is the 2nd edition, Cold Spring HarborLaboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989.

In another embodiment, recombinant mammalian expression vector can instruct described nucleic acid preferentially to express (for example expressing described nucleic acid with the tissue specificity regulatory element) in specific cell type.The tissue specificity regulatory element is known in the art.The limiting examples of suitable tissue-specific promoter comprises white protein promotor (liver specificity; Pinkert etc. (1987) Genes Dev.1:268-277), lymph (lymphoid) specificity promoter (Calame and Eaton (1988) Adv.Immunol.43:235-275), particularly promotor of TXi Baoshouti (Winoto and Baltimore (1989) EMBO J.8:729-733) and immunoglobulin promoter (Banerji etc. (1983) Cell 33:729-740; Queen and Baltimore (1983) Cell 33:741-748), neuronal specificity promotor (neurofilament promotor for example; Byrne and Ruddle (1989) PNAS86:5473-5477), pancreas specificity promoter (Edlund etc. (1985) Science 230:912-916) and mammary gland-specific promotor (whey promotor for example; U.S. Patent number 4,873,316 and European Patent Application No. 264,166).Also comprise and grow adjustment type promotor, for example muroid hox promotor (Kessel and Gruss (1990) Science 249:374-379) and afp promoter (Campes and Tilghman (1989) Genes Dev.3:537-546).

The present invention also provides and comprises the recombinant expression vector of being cloned into the dna molecular of the present invention in the expression vector with antisense orientation.That is described dna molecular with regulate sequence and be connected effectively, its mode of connection provides the expression (by transcribing described dna molecular) of the antisense rna molecule of SMP mRNA.Can select effectively to be connected in antisense orientation clone's nucleic acid, the adjusting sequence of guidance described antisense rna molecule of continuous expression in the various kinds of cell type, for example viral promotors and/or enhanser perhaps can select to instruct the adjusting sequence of composing type, tissue specificity or cell type specificity antisence RNA.Antisense expression vector can be the form of recombinant vectors, phagemid or attenuated virus, and wherein antisense nucleic acid produces under the control of efficient regulatory region, and its activity can be by the cell type decision that described carrier imported.For the discussion of the genetic expression adjusting of using inverted defined gene, referring to Weintraub, H. etc., as the sense-rna of genetic analysis molecular tool, Reviews-Trends in Genetics, the 1st (1) volume 1986.

Another aspect of the present invention relates to the host cell that imports recombinant expression vector of the present invention.Term " host cell " and " recombinant host cell " are used interchangeably in this article.Self-evident, this term is meant that not only specific topic states cell, and refers to the filial generation or the potential filial generation of this cell.Because in the successive generation since sudden change or environmental influence and some modification may take place so this class filial generation in fact may be incomplete same with parental cell, but still be included in the term scope as herein described.

Host cell can be any prokaryotic cell prokaryocyte or eukaryotic cell.For example, SMP albumen can for example be expressed in Corynebacterium glutamicum, insect cell, yeast cell or the mammalian cell (for example Chinese hamster ovary cell (CHO) or COS cell) at bacterial cell.Other proper host cell is well known by persons skilled in the art.Microorganism relevant with Corynebacterium glutamicum, that can be used as the host cell of nucleic acid of the present invention and protein molecular easily is shown in table 3.

Can transform or rotaring dyeing technology by conventional, carrier DNA is imported in prokaryotic cell prokaryocyte or the eukaryotic cell.Term used herein " conversion " and " transfection ", " joint " and " transduction " are meant the multiple technologies that are used for exogenous nucleic acid (as the nucleic acid (for example plasmid, phage, phasmid (phasmid), phagemid (phagemid), transposon or other DNA) of linear DNA or RNA (as linearized vector or do not comprise the gene constructs of carrier) or carrier format) is imported host cell well known in the art, comprise the transfer or the electroporation of transfection, the fat transfection of calcium phosphate or calcium chloride co-precipitation, the mediation of DEAE-dextran, natural competence, chemical substance mediation.Be used to transform or the appropriate method of transfection host cell can be at (MolecularCloning:A Laboratory Manual. the 2nd edition such as Sambrook, Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989) and in other laboratory manual find.

About the stable transfection of mammalian cell, known to used expression vector and rotaring dyeing technology, only the sub-fraction cell can be incorporated into foreign DNA in its genome.In order to identify and select these integrons, the gene of the selective marker of will encoding usually (as antibiotics resistance) imports in the host cell with goal gene.Preferred selective marker comprises gives the medicine selective marker of the resistance of G418, Totomycin and methotrexate for example.The nucleic acid of coding selective marker can be imported host cell on the proteic identical carrier of coding SMP, perhaps it can be imported on independent carrier.Can identify the nucleic acid stability cells transfected that imports (cell that has for example mixed selectable marker gene will be survived, and other necrocytosis) by medicament selection.

In order to obtain the homologous recombination microorganism, preparation contains the carrier of at least a portion SMP gene, has introduced disappearance in described SMP Gene Partial, add or has replaced to change (for example functional destruction) described SMP gene thus.Preferably this SMP gene is a Corynebacterium glutamicum SMP gene, but it can be from Related Bacteria or even the homologue in Mammals, yeast or insect source.In a preferred embodiment, design described carrier, make after homologous recombination, described endogenous SMP gene is by functional destruction (i.e. encoding function albumen no longer; Be also referred to as " knocking out " carrier).Perhaps, can design described carrier, make after homologous recombination, described endogenous SMP gene is suddenlyd change or is changed, but still encoding function albumen (for example can change the upstream regulation district, to change the proteic expression of described endogenous SMP thus).In described homologous recombination vector, the change of described SMP gene part is at the nucleic acid of its 5 ' end and the another kind of SMP gene of 3 ' end adjacency, makes it possible between entrained external source SMP gene of described carrier and the endogenous SMP gene in the microorganism homologous recombination take place.Described another kind of flank SMP nucleic acid has the length that is enough to native gene success homologous recombination.Usually, the flanking DNA (5 ' end and 3 ' end) (description of relevant homologous recombination vector, referring to for example Thomas, K.R. and Capecchi, M.R. (1987) Cell 51:503) that in described carrier, comprises thousands of bases.Described carrier is imported in the microorganism (for example passing through electroporation), then SMP gene that is wherein imported with the choice of technology known in the art and the endogenous SMP dna homolog cell of recombinating.

In another embodiment, can produce the recombinant microorganism that contains selecting system, described selecting system provides the expression of institute's quiding gene of being regulated.For example, be included in the SMP gene that places under the control of lac operon on the carrier, allowing described SMP gene only when IPTG exists, to express.This class regulation system is well-known in the art.

In another embodiment, destroy the endogenous SMP gene (for example by homologous recombination or other genetic method known in the art) in the host cell, the feasible expression that its protein product does not take place.In another embodiment,, changed the endogenous or SMP gene that imported in the host cell by one or more point mutation, disappearance or inversion, but its encoding function SMP albumen still.In an embodiment again, changed one or more regulatory regions of SMP gene in the microorganism (for example promotor, repressor or inductor) (for example by disappearance, brachymemma, inversion or point mutation), make and regulate described SMP expression of gene.One skilled in the art will appreciate that the described SMP gene and the protein modified host cell that contain more than one can adopt method of the present invention easily to produce, and be included in the present invention.

Host cell of the present invention (for example prokaryotic cell prokaryocyte in the culture or eukaryotic cell) can be used for producing (promptly expressing) SMP albumen.Therefore, the present invention also provides and uses host cell of the present invention to produce the proteic method of SMP.In one embodiment, described method is included in the suitable medium cultivates host cell of the present invention and (has wherein imported the proteic recombinant expression vector of coding SMP, or the proteic gene of the SMP that in its genome, has imported encoding wild type or change), until producing SMP albumen.In another embodiment, described method also comprises separation SMP albumen from substratum or from host cell.

C. isolating SMP albumen

Another aspect of the present invention relates to isolating SMP albumen and biologically-active moiety thereof." isolating " or " purifying " albumen or its biologically-active moiety are substantially free of cellular material when producing by recombinant DNA technology, or are substantially free of precursor or other chemical substance when chemosynthesis.Term " is substantially free of cellular material " and comprises the isolating SMP protein Preparation of the cellular component thing that natural generation in the wherein smp protein and cell or reorganization produce.In one embodiment, term " be substantially free of cellular material " and comprise the non-SMP albumen (being also referred to as " contaminating protein " herein) that is contained be lower than about 30% (with dry weight basis), more preferably less than 20%, again more preferably less than about 10%, most preferably be lower than about 5% SMP protein Preparation thing.When reorganization produced described SMP albumen or its biologically-active moiety, it did not preferably contain substratum substantially yet.It is about 20% to be that substratum is less than, and more preferably less than about 10%, most preferably is less than about 5% protein Preparation thing amount.Term " is substantially free of precursor or other chemical substance " and comprises wherein SMP albumen and relates to described albumen synthetic precursor or the isolating SMP protein Preparation of other chemical substance thing.In one embodiment, term " be substantially free of precursor or other chemical substance " and comprise the precursor that had or non-SMP chemical substance be lower than about 30% (with dry weight basis), more preferably less than 20%, again more preferably less than about 10%, most preferably be lower than about 5% SMP protein Preparation thing.In preferred embodiments, isolating protein or its biologically-active moiety be not from the contaminating protein that obtains the proteic same biology of described SMP.Usually, Corynebacterium glutamicum SMP albumen produces this proteinoid by for example for example expressing in the Corynebacterium glutamicum in microorganism.

Isolating SMP albumen of the present invention or its part can participate in the carbon compound metabolism of Corynebacterium glutamicum such as sugar, or produce and to be used to drive the energy compound (for example by oxidative phosphorylation) of unfavorable pathways metabolism, or have described one or more activity of table 1.In preferred embodiments, described protein or its part comprise and the enough homologous aminoacid sequences of aminoacid sequence of the present invention (for example sequence table even number SEQ ID NO sequence), make described protein or its part keep to carry out the carbon compound metabolism that participates in Corynebacterium glutamicum such as sugar and by the ability such as the process generate energy molecule of oxidative phosphorylation.Described proteic described part biologically-active moiety preferably as herein described.In another preferred embodiment, SMP albumen of the present invention has in the sequence table aminoacid sequence shown in the even number SEQ ID NO.In a preferred embodiment again, described SMP albumen has under stringent condition the coded aminoacid sequence of nucleotide sequence with nucleotide sequence of the present invention (for example sequence table odd number SEQ ID NO sequence) hybridization.In another preferred embodiment, described SMP albumen has by following nucleotide sequence coded aminoacid sequence or its part, the homology of wherein said nucleotide sequence and a kind of nucleotide sequence of the present invention is at least about 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59% or 60%, preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69% or 70%, more preferably at least about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79% or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89% or 90%, or 91%, 92%, 93%, 94%, even more preferably at least about 95%, 96%, 97%, 98%, 99% or higher.The present invention also comprises the scope and sign numerical value (for example 70-90% is identical or 80-95% identical) between the above-mentioned numerical value.For example, comprise the above-mentioned value that adopts any combination ident value scope as the upper limit and/or lower limit.The preferred SMP albumen of the present invention also preferably has at least a SMP activity as herein described.For example, preferred SMP albumen of the present invention comprise by with the nucleotide sequence coded aminoacid sequence of a kind of nucleic acid array hybridizing of the present invention, for example hybridize under stringent condition, and can participate in the carbon compound metabolism of Corynebacterium glutamicum such as sugar and, perhaps have one or more activity that table 1 provides by process generate energy molecule (for example ATP) such as oxidative phosphorylation.

In other embodiments, described SMP albumen and a kind of aminoacid sequence of the present invention (for example sequence table even number SEQ ID NO sequence) be homology basically, and the proteic functionally active that keeps one of aminoacid sequence of the present invention, but because natural variation or mutagenesis are different at aminoacid sequence, as describing in detail in the above I trifle.Therefore, in another embodiment, described SMP albumen is a kind of like this protein: the aminoacid sequence that described protein comprised and a kind of homology of complete amino acid sequence of the present invention are at least about 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59% or 60%, preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69% or 70%, more preferably at least about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79% or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89% or 90%, or 91%, 92%, 93%, 94%, even more preferably at least about 95%, 96%, 97%, 98%, 99% or higher, and have at least a SMP activity as herein described.The present invention also comprises the scope and sign numerical value (for example 70-90% is identical or 80-95% identical) between the above-mentioned numerical value.For example, comprise the above-mentioned value that adopts any combination ident value scope as the upper limit and/or lower limit.In another embodiment, the present invention relates to and a kind of complete amino acid sequence of the present invention Corynebacterium glutamicum albumen of homologous total length basically.

The proteic biologically-active moiety of SMP comprise comprise derived from the aminoacid sequence of SMP Argine Monohydrochloride sequence (for example sequence table even number SEQ ID NO: aminoacid sequence) or with the peptide of the Argine Monohydrochloride sequence of SMP albumen homology, its amino acid that comprises is less than total length SMP albumen or with the full length protein of SMP albumen homology and have at least a SMP protein-active.Usually, biologically-active moiety (peptide, for example length for example is 5,10,15,20,30,35,36,37,38,39,40,50,100 or more a plurality of amino acid whose peptide) comprises and has at least a SMP proteic active structures territory or motif.In addition, other biologically-active moiety of wherein said proteinic other district's disappearance can prepare by recombinant technology, and estimates according to one or more activity as herein described.Preferably the proteic biologically-active moiety of SMP comprises one or more selected structural domain/motif or its part of biologically active.

SMP albumen preferably produces by recombinant DNA technology.For example, the cloned nucleic acid molecule of code for said proteins in expression vector (as mentioned above), is imported host's (as mentioned above) with described expression vector, in described host cell, express described SMP albumen then.Can adopt standard protein purification technique by suitable purification scheme then, from described cell, isolate described SMP albumen.As recombinant expressed alternative method, can use the standard peptide synthetic technology, chemosynthesis SMP albumen, polypeptide or peptide.In addition, can for example adopt by standard technique, the anti-SMP antibody that utilizes SMP albumen of the present invention or its fragment to produce, separating natural SMP albumen from described cell (for example endotheliocyte).

The present invention also provides SMP chimeric protein or fusion rotein.SMP used herein " chimeric protein " or " fusion rotein " comprise the SMP polypeptide that effectively is connected with non-SMP polypeptide." SMP polypeptide " is meant to have the polypeptide that is equivalent to the proteic aminoacid sequence of SMP, and " non-SMP polypeptide " is meant that the aminoacid sequence that is had is equivalent to and the described SMP albumen proteinic polypeptide of homologous not basically, for example is different from described SMP albumen and derives from same biology or different biological protein.In described fusion rotein, term " effective connection " is meant that described SMP polypeptide and described non-SMP polypeptide merge by frame each other.Described non-SMP polypeptide can merge N-terminal or the C-terminal to described SMP polypeptide.For example, in one embodiment, described fusion rotein is that wherein the SMP sequence merges to the GST-SMP fusion rotein of the C-terminal of GST sequence.This class fusion rotein can be so that purification of Recombinant SMP albumen.In another embodiment, described fusion rotein is the SMP albumen that contains an allos signal sequence at N-terminal.At some host cell (for example in the mammalian host cell), can increase proteic expression of SMP and/or secretion by utilizing the allos signal sequence.

SMP chimeric protein preferably of the present invention or fusion rotein adopt the standard recombinant dna technology to produce.For example, according to routine techniques, for example by utilizing flush end or stagger end to connect, carry out Restriction Enzyme digestion suitable end, the suitable flat cohesive end of time candidate to be provided, to carry out alkaline phosphatase treatment to avoid undesirable connection, carry out enzyme then and connect, the dna fragmentation of the different peptide sequences of coding is linked together with meeting frame.In another embodiment,, comprise automatic dna synthesizer, can synthesize described fusion gene by routine techniques.Perhaps, adopt anchor primer to carry out the pcr amplification of gene fragment, described anchor primer produces complementary overhang between two consecutive gene fragments, subsequently with its annealing and amplification again, produce chimeric gene sequence (referring to for example Current Protocols in Molecular Biology, Ausubel etc. write, John Wiley ﹠amp; Sons:1992).In addition, many expression vectors are commercially available, and encoded one merges part (for example gst polypeptide).The SMP coding nucleic acid can be cloned in a kind of like this expression vector, make described fusion part meet frame ground and merge with described SMP albumen.

By described SMP albumen is carried out mutagenesis, for example Li San point mutation or brachymemma can produce the proteic homologue of described SMP.Term used herein " homologue " is meant as the agonist of described SMP protein-active or the proteic variant form of described SMP of antagonist.The proteic agonist of SMP can keep the biological activity of a proteic identical biological activity of described SMP or a subclass basically.The proteic antagonist of SMP is by for example competitive in conjunction with comprising that SMP proteic glycan molecule metabolism cascade or energy produce the downstream or the upstream member of approach, can suppress proteic one or more activity of natural form SMP.

In an alternate embodiment, the proteic mutant of described SMP that has SMP protein agonist or an antagonistic activity by screening is the combinatorial library of truncated mutant for example, can identify the proteic homologue of described SMP.In one embodiment, by carry out associating mutagenesis on nucleic acid level, producing a piebald library of SMP varient, is encoded by a piebald gene library in described piebald library.By for example enzyme process the synthetic oligonucleotide mixture is connected in the gene order, make the potential SMP sequence of one group of degeneracy can act on single expression of polypeptides, perhaps, can obtain SMP varient piebald library as the one group of bigger expressing fusion protein (for example being used for phage display) that wherein contains one group of SMP sequence.There is several different methods can produce potential SMP homologue library with the oligonucleotide sequence of cause degeneracy.Can in automatic dna synthesizer, carry out the chemosynthesis of degeneracy gene order, then described synthetic gene is connected in the suitable expression vector.Use one group of degeneracy gene, the feasible sequence that can in a kind of mixture, provide all to encode one group of required potential SMP sequence.The method of synthetic degenerate oligonucleotide be known in the art (referring to for example Narang, S.A. (1983) Tetrahedron 39:3; Itakura etc. (1984) Annu.Rev.Biochem.53:323; Itakura etc. (1984) Science 198:1056; Ike etc. (1983) Nucleic Acid Res.11:477).

In addition, the segmental library of described SMP encoding histone can be used for producing the segmental piebald of SMP colony, is used for screening and select the proteic homologue of SMP subsequently.In one embodiment, the segmental library of following generation encoding sequence: the double-stranded PCR fragment with nuclease treatment S MP encoding sequence approximately only takes place at each molecule under the condition of a breach, make described double-stranded DNA sex change, what described DNA renaturation is formed can comprise different breach products has a right double-stranded DNA of justice/antisense, from the duplex that forms again, remove the strand part by handling, then the fragment library that is produced is connected in the expression vector with the S1 nuclease.In this way, can obtain an expression library, the proteic N-terminal fragment of described SMP, C-terminal fragment and the interior segments of described expression library coding all size.

Several technology known in the art is used to screen the gene product of the combinatorial library for preparing by point mutation or brachymemma and the gene product that screening cDNA library searching has selected characteristic.This class technology is applicable to that rapid screening passes through the gene library that combinatorial mutagenesis SMP homologue produces.Be suitable for high throughput analysis, be used to screen the most widely used technology of big gene library, comprise described gene library is cloned in the rf expression vector, transform suitable cell with the vector library that is produced, and make described combination gene help to express under the isolating condition of carrier in required active detection, and the detected gene of its gene product of described vector encoded.The overall mutagenesis (REM) that circulates is a kind of new technology that improves functional type mutant frequency in the library, can be used in combination (Arkin and Yourvan (1992) PNAS89:7811-7815 with the screening assay of identifying the SMP homologue; Delgrave etc. (1993) Protein Engineering 6 (3): 327-331).

In another embodiment, can adopt method well known in the art, use based on the mensuration of cell and analyze piebald SMP library.

D. application of the present invention and method

Nucleic acid molecule as herein described, protein, protein homologs, fusion rotein, primer, carrier and host cell can be used for one or more following methods: identify Corynebacterium glutamicum and associated biomolecule; The genomic mapping of the biology relevant with Corynebacterium glutamicum; Identify and location purpose Corynebacterium glutamicum sequence; Study on Evolution; The SMP protein region that measurement function is required; Regulate the SMP protein-active; Regulate one or more carbohydrate metabolisms; Regulate cell and produce high energy molecule (being ATP, NADPH); And the generation of adjusting cell needs compound (for example fine chemicals).

SMP nucleic acid molecule of the present invention serves many purposes.At first, they can be used for identifying Corynebacterium glutamicum and its closely-related bacterial classification.In addition, whether they can be used in the Identifying micro-organisms population mixture the relevant bacterial classification with it of Corynebacterium glutamicum.The invention provides the nucleotide sequence of many Corynebacterium glutamicum genes; By under stringent condition, using the probe of crossing over the peculiar gene region of Corynebacterium glutamicum, survey the genomic dna that a kind of microbial population and mixing microorganisms colony culture are extracted, thereby people can determine whether to exist the L-glutamic acid bacillus.

Though Corynebacterium glutamicum self is a non-virulent, for example corynebacterium diphtheriae is relevant with pathogenic species for it.Corynebacterium diphtheriae is the diphtheria pathogenic agent, and diphtheria is that a kind of febris acuta sexuality that relates to the fast development of local and systematic pathology is dyed.In this disease, local patholoic change betides the upper respiratory tract, and relates to the damage of epithelial cell gangrenosum acne; Corynebacterium diphtheriae excretes poison, the distant place susceptible tissue of toxin from the local patholoic change disperse to body.Because suppressing the protein synthesis of various tissues sex change takes place, cause the diphtheria systematic pathology, described tissue comprises heart, muscle, peripheral nerve, suprarenal gland, kidney, liver and spleen.Diphtheria comprises that in many areas, the world sickness rate is very high always in the many independent states of Africa, Asia, European east and USSR (Union of Soviet Socialist Republics).Since nineteen ninety, 5,000 people's death have been caused in that latter two geographic diphtheria is popular.

In one embodiment, the invention provides a kind of method that whether has corynebacterium diphtheriae or its active situation in the subject of identifying.This method comprises identifies one or more nucleotide sequences of the present invention or aminoacid sequence (for example being respectively the sequence shown in sequence table odd number or the even number SEQ ID NO) in the subject, detects whether have Corynebacterium glutamicum or active situation in the described subject thus.Corynebacterium glutamicum and corynebacterium diphtheriae are Related Bacteria, and therefore the many nucleic acid in the Corynebacterium glutamicum and the nucleic acid of protein molecule and corynebacterium diphtheriae and protein molecule homology can be used for detecting the intravital corynebacterium diphtheriae of experimenter.

Nucleic acid molecule of the present invention and protein molecule also can be as the marks of genome given zone.This not only can be applicable in the genomic mapping, also can be applicable to the proteic functional study of Corynebacterium glutamicum.For example, for the conjugated protein institute of specific Corynebacterium glutamicum DNA bonded zone in the identified gene group, can be with Corynebacterium glutamicum gene group digestion, then with fragment with the conjugated protein incubation of described DNA.Can survey with nucleic acid molecule of the present invention in addition in conjunction with described proteic fragment, preferably survey with the mark that can detect easily; This nucleic acid molecule and combining of described genomic fragment make it possible to above-mentioned fragment be positioned on the Genome Atlas of Corynebacterium glutamicum, and when carrying out repeatedly, help the rapid determination of described albumen institute bonded nucleotide sequence with different enzymes.In addition, nucleic acid molecule of the present invention may have enough homologys with the sequence of relevant bacterial classification, so these nucleic acid molecule can be as the mark that for example makes up Genome Atlas in Related Bacteria in the brevibacterium.

SMP nucleic acid molecule of the present invention also can be used for Study on Evolution and protein structure research.Metabolism and energy dispose procedure that molecule of the present invention participates in are utilized by various prokaryotic organism and eukaryotic cells; By the sequence of nucleic acid molecules of comparison sequence of nucleic acid molecules of the present invention, can estimate biological evolution dependency to the similar enzyme of other biology of coding.Equally, does not guard in guard in which district of the described sequence of this relatively permission evaluation, which district, and this helps definite necessary protein region of enzyme function.Research is valuable to such mensuration for protein engineering, and can provide protein and can tolerate and the index of not loss of function aspect mutagenesis.

Can cause producing to the operation of SMP nucleic acid molecule of the present invention and be different from the proteic SMP albumen of wild-type SMP on the function.But these protein energy efficiency aspects or active aspect are improved, and the quantity that exists in cell may be greater than common quantity, but or energy efficiency or active the reduction.

The invention provides screening method, be used to screen by with protein self or the proteic substrate of described SMP or binding partners interacts or transcribe or translate the molecule of regulating the SMP protein-active by what regulate SMP nucleic acid molecule of the present invention.In these class methods, the proteic microorganism of one or more SMP of the present invention of expression is contacted with one or more test compounds, and estimate of the influence of every kind of test compound described SMP protein-active or expression level.

SMP albumen of the present invention change can by number of mechanisms directly influence mix productive rate that the proteic Corynebacterium glutamicum strain of this change produces fine chemicals, output and/and production efficiency.Such as the high-energy carbon molecular degradation of sugar and be converted into more useful form such as the compound of NADH and FADH2 by oxidative phosphorylation and can produce multiple compound, the fine chemicals that these compounds may need exactly itself is as pyruvic acid, ATP, NADH and multiple intermediate sugar compounds.And then kinetomeres (as ATP) and reducing equivalent thing (as NADH or NADPH) that cell can utilize these pathways metabolisms to produce drive disadvantageous reaction on energy.Such adverse effect comprises many fine chemicals biosynthetic pathways.The ability of people by improving cell and utilize specific sugar (for example operation coding gene that to participate in described cell degradation Nulomoline be the enzyme of energy), can improve energy, but so that cell can carry out the unfavorable metabolic reaction that still needs (the synthetic fine chemicals that needs of biological example).

In addition, can optimize the energy that the Nulomoline molecule contains, so that produce the fine chemicals that one or more need to the regulating of one or more approach of involved in sugar utilization.For example participate in for example enzymic activity of gluconeogenesis, can obtain more ATP for the required biochemical reaction of cellular driven (for example fine chemicals biosynthesizing) by reduction.In addition, also can regulate the energy maximization of total energy molecule generation to guarantee that cell is produced by each glycan molecule of sugar.Invalid sugar utilization may produce excessive carbon dioxide and excessive energy, and excessive energy may produce useless metabolic cycles.By improving the glycan molecule metabolism, cell is functionating more effectively, and needs less carbon molecule.This also should obtain improved fine chemicals: glycan molecule is than (improve carbon productive rate), and can reduce the sugar amount that must add in this engineering Corynebacterium glutamicum of the hundred major scale fermentation culture in the substratum.

One or more SMP genes of the present invention of mutagenesis also may produce the SMP albumen of activity change, and the SMP albumen remote effect Corynebacterium glutamicum of activity change produces one or more needs fine chemicals.For example, people utilize one or more sugared efficient (being converted into useful kinetomeres thereby strengthen described sugar) or improve the efficient (for example by improving oxidative phosphorylation efficient or strengthening the atp synthase activity) that the reducing equivalent thing is converted into useful kinetomeres by improving Corynebacterium glutamicum, can increase these high energy compound amounts, for the common disadvantageous metabolic process of cellular driven.Unfavorable process like this comprise make up cell walls, transcribe, translation and essential compound (for example Nucleotide, amino acid, VITAMIN, lipid etc.) (Lengeler etc. (1999) the Biology of Prokaryotes of biosynthesizing cell growth division, Thieme Verlag:Stuttgart, 88-109,913-918,875-899 page or leaf).By growth and the breeding that improves these engineering cells, both can improve the cell viability in the large scale culturing thing, also can improve its division rate, more substantial like this cell can be survived in the fermentor cultivation thing.At least because exist more generation to need the viable cell of fine chemicals and improve productive rate, output or production efficiency.

In addition, cell itself utilizes many degraded products of carbohydrate metabolism generation as the precursor or the intermediate that produce countless other useful compounds (wherein part is a fine chemicals).For example pyruvic acid is converted into amino acid alanine, and ribose-5-phosphoric acid is an integral part of nucleic acid molecule for example.Therefore, glycometabolic amount and efficient have remarkably influenced to the validity of these degraded products in cell.By (for example engineering improvement participates in the enzyme of these approach in the ability that strengthens cellular metabolism sugar aspect the efficient of existing approach, thereby optimize its activity), perhaps participate in the validity (for example increasing the quantity of these enzymes that exist in the cell) of the enzyme of these approach by raising, also can improve the validity of these degraded products in cell, produce many different other and need compound (for example fine chemicals) thereby strengthen cell again.

The above-mentioned SMP albumen mutagenesis strategy that Corynebacterium glutamicum fine chemicals productive rate is improved is not restrictive; It is conspicuous for those skilled in the art that these strategies are changed.Employ these tactics and add mechanism disclosed herein, can utilize nucleic acid molecule of the present invention and protein molecule to produce the Corynebacterium glutamicum or the Related Bacteria bacterial classification of expressing mutant SMP nucleic acid molecule and protein molecule, making needs productive rate, output and/or the production efficiency of compound to be improved.This compound that needs can be the spawn of Corynebacterium glutamicum, comprise the end product of biosynthetic pathway and the intermediate of naturally occurring pathways metabolism, and be not molecule naturally occurring but that produce by Corynebacterium glutamicum strain of the present invention in the Corynebacterium glutamicum metabolism.

Use following examples and further illustrate the present invention, it should be construed as limiting the invention.The content of patent application, form and the sequence table of all reference of quoting in this application, patent application, patent, announcement all is attached to herein by reference.

Table 1: the gene among the application

HMP: nucleic acid SEQ ID NO	Amino acid SEQ ID NO	Identification code	Contig	NT is initial	NT stops	Function
							1357 TCA: nucleic acid SEQ IDNO	2468 amino acid SEQ ID NO	RXS02735 RXA01626 RXA02245 RXA01015 identification code	VV0074 GR00452 GR00654 GR00290 contig	14,576 4,270 13,639 346 NT are initial	15,280 3,926 14,295 5 NT stop	6-phosphogluconic acid enzyme lactonase L-ribulose-phosphatase 24-epimerase ribulose-phosphoric acid 3-epimerase (EC 5.1.31) ribose 5-phosphoric acid isomerase (EC 5.3.1.6) function
9 11 13 15 17 19 21 EMB-approach nucleic acid SEQ ID NO	10 12 14 16 18 20 22 amino acid SEQ ID NO	RXN01312 FRXA01312 RXN00231 RXA01311 RXA01535 RXA00517 RXA01350 identification code	VV0082 GR00380 VV0083 GR00380 GR00427 GR00131 GR00392 contig	20,803 2,690 15,484 1,611 1,354 1,407 1844 NT are initial	18,785 1,614 14,015 865 2,760 2,447 2827 NT stop	Succinodehydrogenase flavoprotein subunit of succinodehydrogenase flavoprotein subunit (EC 1.3.99.1) (EC 1.3.99.1) succsinic acid-hemiacetal desaturase (NADP+) (EC 1.2.1.16) succinodehydrogenase iron-sulphur protein (EC 1.3.99.1) fumaric acid hydratase precursor (EC 4.2.1.2.) malate dehydrogenase (malic acid dehydrogenase) (EC 1.1.1.37) (EC 1.1.1.82) malate dehydrogenase (malic acid dehydrogenase) (EC 1.1.1.37) function
							23 25 27 29 31 33 35 37 39 41 43 45 47 49 51 53 55 57	24 26 28 30 32 34 36 38 40 42 44 46 48 50 52 54 56 58	RXA02149 RXA01814 RXN02803 FRXA02803 RXN03076 FRXA02854 RXA00511 RXN01365 FRXA01365 RXA00098 RXA01989 RXA00340 RXA02492 RXA00381 RXA02122 RXA00206 RXA01243 RXA01882	GR00639 GR00515 VV0086 GR00784 VV0043 GR10002 GR00129 VV0091 GR00397 GR00014 GR00578 GR00059 GR00720 GR00082 GR00636 GR00032 GR00359 GR00538	17786 2571 1 1 1624 1588 1 1476 897 6525 1 1549 2201 1451 6511 6171 2302 1165	18754 910 657 400 35 5 513 103 4 8144 630 2694 2917 846 5813 5134 3261 2154	( EC 2.7.1.2 ) ( EC 5.4.2.2. ) / ( EC 5.4.2.8 ) ( EC 5.4.2.2. ) / ( EC 5.4.2.8 ) ( EC 5.4.2.2. ) / ( EC 5.4.2.8 ) ( EC 5.4.2.2. ) / ( EC 5.4.2.8 ) ( EC 5.4.2.2. ) / ( EC 5.4.2.8 ) ( EC 5.4.2.2. ) / ( EC 5.4.2.8 ) ( EC 5.4.2.2. ) / ( EC 5.4.2.8 ) ( EC 5.4.2.2. ) / ( EC 5.4.2.8 ) -6- ( GPI ) ( EC 5.3.1.9 ) -6-A ( GPI A ) ( EC 5.3.1.9 ) ( EC 5.4.2.1 ) ( EC 5.4.2.1 ) ( EC 5.4.2.1 ) ( EC 5.4.2.1 ) 6- ( EC 2.7.1.11 ) 1- ( EC 2.7.1.56 ) 1- ( EC 2.7.1.56 )

Table 1 (continuing)

Nucleic acid SEQ ID NO	Amino acid SEQ ID NO	Identification code	Contig	NT is initial	NT stops	Function
							?59?61?63?65?67?69?71?73?75?77?79?81?83?85?87?89?91?93?95?97?99?101?103?105?107?109?111?113?115?117?119?121?123?125?127?129?131?133?135?137	60 62 64 66 68 70 72 74 76 78 80 82 84 86 88 90 92 94 96 98 100 102 104 106 108 110 112 114 116 118 120 122 124 126 128 130 132 134 136 138	RXA01702 RXA02258 RXN01225 FRXA01225 RXA02256 RXA02257 RXA00235 RXA01093 RXN02675 FRXA02675 FRXA02695 RXA00682 RXA00683 RXN00635 FRXA02807 FRXA00635 RXN03044 FRXA02852 FRXA00268 RXN03086 FRXA02887 RXN03043 FRXA02897 RXN03083 FRXA02853 RXA02259 RXN02326 FRXA02326 RXN2327 FRXA02327 RXN02328 FRXA02328 RXN01048 FRXA01048 FRXA00290 RXA02694 RXN00296 FRXA00296 RXA01901 RXN01952	GR00479 GR00654 VV0064 GR00354 GR00654 GR00654 GR00036 GR00306 VV0098 GR00754 GR00755 GR00179 GR00179 VV0135 GR00788 GR00167 VV0019 GR00852 GR00041 VV0049 GR10022 VV0019 GR10039 VV0047 GR10001 GR00654 VV0047 GR00668 VV0047 GR00668 VV0047 GR00668 VV0079 GR00296 GR00046 GR00755 VV0176 GR00048 GR00544 VV0105	1397 26451 6382 5302 23934 25155 2365 1552 72801 2 2949 5299 6440 22708 88 3 1391 3 125 2243 411 1 1291 88 89 27401 4500 5338 3533 6305 1842 7783 12539 3 4693 1879 35763 3 4158 9954	366 27227 4943 6741 24935 26369 1091 122 70945 364 4370 3401 5349 20972 552 923 2221 281 955 2650 4 1362 5 1110 1495 30172 5315 4523 4492 5346 3437 6401 11316 290 5655 2820 38606 2837 5417 11666	( EC 4.1.2.13 ) ( EC 5.3.1.1 ) -3- ( EC 1.2.1.12 ) -3- -3- ( EC 1.2.1.12 ) ( EC 2.7.2.3 ) ( EC 4.2.1.11 ) ( EC 2.7.1.40 ) ( EC 2.7.1.40 ) ( EC 2.7.1.40 ) ( EC 2.7.1.40 ) ( EC 2.7.9.2 ) ( EC 2.7.9.2 ) ( ) ( EC 1.2.2.2 ) ( ) ( EC 1.2.2.2 ) ( ) ( EC 1.2.2.2 ) E1 ( EC 1.2.4.1 ) E1 ( EC 1.2.4.1 ) E1 ( EC 1.2.4.1 ) E1 ( EC 1.2.4.1 ) E1 ( EC 1.2.4.1 ) E1 ( EC 1.2.4.1 ) E1 ( EC 1.2.4.1 ) ( EC 1.8.1.4 ) ( EC 1.8.1.4 ) ( EC 4.1.1.31 ) ( EC 6.4.1.1 ) ( EC 6.4.1.1 ) ( EC 6.4.1.1 ) ( EC 6.4.1.1 ) ( EC 1.1.1.39 ) ( EC 1.1.1.39 ) ( EC 1.1.1.39 ) L- ( EC 1.1.1.27 ) D- ( ) ( EC 1.1.2.4 ) D- ( ) ( EC 1.1.2.4 ) L- ( ) ( EC 1.1.2.3 ) D- ( EC 1.1.1.28 )

Table 1 (continuing)

Nucleic acid SEQ ID NO	Amino acid SEQ ID NO	Identification code	Contig	NT is initial	NT stops	Function
							139 141 143 145 147 149 151 153 155 157 159 161 163 165 167 169 171 173 175 177 179 181 183	140 142 144 146 148 150 152 154 156 158 160 162 164 166 168 170 172 174 176 178 180 182 184	FRXA01952 FRXA01955 RXA00293 RXN01130 FRXA01130 RXN03112 FRXA01133 RXN00871 FRXA00871 RXN02829 FRXA02829 RXN01468 FRXA01468 RXA00794 RXN02920 FRXA02379 RXN02688 RXN03087 RXN03186 RXN03187 RXN02591 RXS01260 RXS01261	GR00562 GR00562 GR00047 VV0157 GR00315 VV0085 GR00316 VV0127 GR00239 VV0354 GR00816 VV0019 GR00422 GR00211 VV0213 GR00690 VV0098 VV0052 VV0377 VV0382 VV0098 VV0009 VV0009	1 4,611 2,645 6,138 2 509 568 3,127 2,344 287 287 7,474 1,250 3,993 6,135 1,390 59,053 3,216 310 3 14,370 3,477 3703	216 6,209 1,734 5,536 304 6 1,116 2,240 3,207 559 562 8,298 2,074 2,989 5,224 686 58,385 3,428 519 281 12,541 2,296 3533	D-serum lactic dehydrogenase ( EC 1.1.1.28 ) D-serum lactic dehydrogenase ( EC 1.1.1.28 ) D-3-phosphoglycerate dehydrogenase ( EC 1.1.1.95 ) D-3-phosphoglycerate dehydrogenase ( EC 1.1.1.95 ) D-3-phosphoglycerate dehydrogenase ( EC 1.1.1.95 ) D-3-phosphoglycerate dehydrogenase ( EC 1.1.1.95 ) D-3-phosphoglycerate dehydrogenase ( EC 1.1.1.95 ) IOLB protein I OLB albumen: D-fructose 1,6-bisphosphate=glycerosone-CC phosphoric acid+D-Glycerose 3-phosphoric acid.IOLS IOLS NAGD N--2- GLPX D-3- ( EC 1.1.1.95 ) D-3- ( EC 1.1.1.95 ) ( EC 5.4.2.1 ) ( EC 6.4.1.1 ) E1 ( EC 1.2.4.1 ) E1 ( EC 1.2.4.1 ) [GTP] ( EC 4.1.1.32 ) α- ( E3 ) ( EC 1.8.1.4 ) α- ( E3 ) ( EC 1.8.1.4 )
The glycerine metabolism
	Nucleic acid SEQ ID NO	Amino acid SEQ ID NO	Identification code	Contig	NT is initial	NT stops	Function
185 187 189 191 193 195 197 199 201 203								186 188 190 192 194 196 198 200 202 204	RXA02640 RXN01025 FRXA01025 RXA01851 RXA01242 RXA02288 RXN01891 FRXA01891 RXA02414 RXN01580	GR00749 VV0143 GR00293 GR00525 GR00359 GR00661 VV0122 GR00541 GR00703 VV0122	1,400 5,483 939 3,515 1,526 992 24,949 1,736 3,808 22091	2,926 4,488 1,853 1,830 2,302 147 24,086 918 3,062 22807	Glycerol kinase, (EC 2.7.1.30) glycerol-3-phosphate dehydrogenase, (NAD, (P)+), (EC 1.1.1.94) glycerol-3-phosphate dehydrogenase, (NAD, (P)+), (EC 1.1.1.94) aerobic glycerol-3-phosphate dehydrogenase, (NAD, (P)+), (EC 1.1.99.5) glycerol-3-phosphate regulon repressor glycerol-3-phosphate regulon repressor glycerol-3-phosphate-in conjunction with periplasm protein precursor glycerol-3-phosphate-participate in the metabolic uncharacterized protein of glycerine in conjunction with the periplasm protein precursor, (homologue of fruit bat rhomboid) Phosphoric acid glycerol esters diester phosphodiesterase

Table 1 (continuing)

Acetate metabolism
	Nucleic acid SEQ ID NO	Amino acid SEQ ID NO	Identification code	Contig	NT is initial	NT stops	Function
205 207 209 211 213 215 217 219 221 223 225 227 229 231 233 235								206 208 210 212 214 216 218 220 222 224 226 228 230 232 234 236	RXA01436 RXA00686 RXA00246 RXA01571 RXA01572 RXA01758 RXA02539 RXN03061 RXN03150 RXN01340 RXN01498 RXN02674 RXN00868 RXN01143 RXN01146 RXN01144	GR00418 GR00179 GR00037 GR00438 GR00438 GR00498 GR00726 VV0034 VV0155 VV0033 VV0008 VV0315 VV0127 VV0077 VV0264 VV0077	2547 8744 4425 1360 1928 3961 11676 108 10678 3 1598 15614 2230 9372 243 8237	1357 7941 3391 1959 2419 2945 10159 437 10055 860 3160 14163 320 8254 935 7722	Acetokinase (EC 2.7.2.1) acetic acid operon repressor protein alcohol dehydrogenase (EC 1.1.1.1) alcohol dehydrogenase (EC 1.1.1.1) alcohol dehydrogenase (EC 1.1.1.1) alcohol dehydrogenase (EC 1.1.1.1) acetaldehyde dehydrogenase (EC acetaldehyde dehydrogenase (EC 1.2.1.3) acetaldehyde dehydrogenase (EC 1.2.1.3) acetaldehyde dehydrogenase (EC 1.2.1.3) acetaldehyde dehydrogenase (EC 1.2.1.3) acetaldehyde dehydrogenase (EC 1.2.1.3) acetolactate synthase large subunit (EC 4.1.3.18) acetolactate synthase large subunit (EC 4.1.3.18) the little subunit of acetolactate synthase large subunit (EC 4.1.3.18) acetolactate synthase (EC 4.1.3.18)
	Butyleneglycol, diacetyl and 3-oxobutanol form
Nucleic acid SEQ ID NO		Amino acid SEQ ID NO	Identification code	Contig	NT is initial	NT stops	Function
	237 239 241							238 240 242	RXA02474 RXA02453 RXS01758	GR00715 GR00710 VV0112	8082 6103 27383	7309 5351 28399	(S, S)-butane-2,3-two alcoholdehydrogenase (EC 1.1.1.76) 3-oxobutanols (diacetyl) reductase enzyme (EC 1.1.1.5) ethanol dehydrogenase (EC 1.1.1.1)
The HMP-circulation
	Nucleic acid SEQ ID NO	Amino acid SEQ ID NO	Identification code	Contig	NT is initial	NT stops	Function
243 245 247 249 251 253								244 246 248 250 252 254	RXA02737 RXA02738 RXA02739 RXA00965 RXN00999 FRXA00999	GR00763 GR00763 GR00763 GR00270 VV0106 GR00283	3312 4499 6769 1232 2817 3012	1771 3420 4670 510 1366 4448	G-6-P 1-desaturase (EC 1.1.1.49) transaldolase (EC 2.2.1.2) transketolase (EC 2.2.1.1) 6-phosphogluconate dehydrogenase, decarboxylation (EC 1.1.1.44) 6-phosphogluconate dehydrogenase, decarboxylation (EC 1.1.1.44) 6-phosphogluconate dehydrogenase, decarboxylation (EC 1.1.1.44)
	The nucleotide sugar conversion
Nucleic acid SEQ ID NO		Amino acid SEQ ID NO	Identification code	Contig	NT is initial	NT stops	Function
	255 257							256 258	RXN02596 FRXA0596	VV0098 GR00742	48784 1	47582 489	UDP-galactopyranose mutase (EC 5.4.99.9) UDP-galactopyranose mutase (EC 5.4.99.9)

Table 1 (continuing)

Nucleic acid SEQ ID NO	Amino acid SEQ ID NO	Identification code	Contig	NT is initial	NT stops	Function
							?259?261?263?265?267?269?271?273?275?277?279?281?283?285	?260?262?264?266?268?270?272?274?276?278?280?282?284?286	FRXA02642 RXA02572 RXA02485 RXA01216 RXA01259 RXA02028 RXA01262 RXA01377 RXA02063 RXN00014 FRXA00014 RXA01570 RXA02666 RXA00825	GR00749 GR00737 GR00718 GR00352 GR00367 GR00616 GR00367 GR00400 GR00626 VV0048 GR00002 GR00438 GR00753 GR00222	5383 2 2345 2302 987 573 8351 3935 3301 8848 4448 427 7260 222	5880 646 3445 1202 130 998 7191 5020 4527 9627 5227 1281 6493 1154	UDP- ( EC 5.4.99.9 ) UDP-6- ( EC 1.1.1.22 ) UDP-N- ( EC 1.1.1.158 ) UDP-N- ( EC 2.7.7.23 ) UTP--1- ( EC 2.7.7.9 ) UTP--1- ( EC 2.7.7.9 ) GDP-6- ( EC 1.1.1.132 ) -1- ( EC 2.7.7.13 ) -1- ( EC 2.7.7.27 ) -1- ( EC 2.7.7.24 ) -1- ( EC 2.7.7.24 ) -1- ( EC 2.7.7.24 ) D--5- ( EC 2.7.7.40 ) DTDP-4,6- ( EC 4.2.1.46 )
Inositol and ribitol metabolism
	Nucleic acid SEQ ID NO	Amino acid SEQ ID NO	Identification code	Contig	NT is initial	NT stops	Function
?287?289?291?293?295?297?299?301?303?305?307?309?311?313								?288?290?292?294?296?298?300?302?304?306?308?310?312?314	RXA01887 RXN00013 FRXA00013 RXA01099 RXN01332 FRXA01332 RXA01632 RXA01633 RXN01406 RXN01630 RXN00528 RXN03057 FRXA02902 RXA00251	GR00539 VV0048 GR00002 GR00306 VV0273 GR00388 GR00454 GR00454 VV0278 VV0050 VV0079 VV0028 GR10040 GR00038	4219 7966 3566 6328 579 552 2338 3380 2999 48113 23406 7017 10277 931	3209 8838 4438 5504 4 4 3342 4462 1977 47037 22318 7688 10948 224	Inositol 2-dehydrogenase (EC 1.1.1.18) inositol-1 (or 4)-one phosphatase 1 (EC 3.1.3.25) inositol-1 (or 4)-one phosphatase 1 (EC 3.1.3.25) inositol monophosphate phosphatase inositol 2-dehydrogenase (EC 1.1.1.18) inositol 2-dehydrogenase (EC 1.1.1.18) inositol 2-dehydrogenase (EC 1.1.1.18) inositol 2-dehydrogenase (EC 1.1.1.18) inositol 2-dehydrogenase (EC 1.1.1.18) inositol 2-dehydrogenase (EC 1.1.1.18) inositol-1-phosphate synthase (EC 5.5.1.4) inositol 2-deaminase (1.1.1.18) glucose-fructose redox enzyme precursor (EC 1.1.99.28) ribitol 2-dehydrogenase (EC 1.1.1.56)
	Utilization about sugar
Nucleic acid SEQ ID NO		Amino acid SEQ ID NO	Identification code	Contig	NT is initial	NT stops	Function
	?315?317?319?321							?316?318?320?322	RXN02654 FRXA02654 RXN01049 FRXA01049	VV0090 GR00752 VV0079 GR00296	12206 7405 9633 1502	13090 8289 11114 492	Glucose 1-desaturase (EC 1.1.1.47) glucose 1-desaturase II (EC 1.1.1.47) gluconokinase (EC 2.7.1.12) gluconokinase (EC 2.7.1.12)

Table 1 (continuing)

Nucleic acid SEQ ID NO	Amino acid SEQ ID NO	Identification code	Contig	NT is initial	NT stops	Function
							?323?325?327?329?331?333?335?337?339?341?343?345?347?349?351?353?355?357?359?361?363?365?367?369?371?373?375?377?379?381?383?385?387?389?391?393?395?397?399?401	324 326 328 330 332 334 336 338 340 342 344 346 348 350 352 354 356 358 360 362 364 366 368 370 372 374 376 378 380 382 384 386 388 390 392 394 396 398 400 402	FRXA01050 RXA00202 RXN00872 FRXA00872 RXN00799 FRXA00799 RXA00032 RXA02528 RXN00316 FRXA00309 RXN00310 FRXA00310 RXA00041 RXA02026 RXA02061 RXN01369 FRXA01369 FRXA01373 RXA02611 RXA02612 RXN01884 FRXA01884 RXA01111 RXN01550 FRXA01550 RXN02100 FRXA02100 FRXA02113 RXA02147 RXA01478 RXA01888 RXN01927 FRXA01927 RXA02729 RXA02797 RXA02730 RXA02551 RXA01325 RXA00195 RXA00196	GR00296 GR00032 VV0127 GR00240 VV0009 GR00214 GR00003 GR00725 VV0006 GR00053 VV0006 GR00053 GR00007 GR00615 GR00626 VV0124 GR00398 GR00399 GR00743 GR00743 VV0184 GR00539 GR00306 VV0143 GR00431 VV0318 GR00631 GR00633 GR00639 GR00422 GR00539 VV0127 GR00555 GR00762 GR00778 GR00762 GR00729 GR00385 GR00030 GR00030	1972 1216 6557 565 58477 1 12028 6880 7035 316 6616 735 1246 725 1842 595 3 595 1 1793 1 3 16981 14749 3 2 3 2 15516 10517 4366 50623 3 747 1739 1768 2193 5676 543 1094	1499 275 5604 1086 56834 1584 10520 7854 8180 5 7050 301 5 6 349 1776 503 1302 1752 3985 1890 1475 17427 16260 1346 2326 920 1207 16532 12352 4923 49244 1118 4 2641 731 2552 5005 1103 1708	( EC 2.7.1.12 ) D- ( EC 2.7.1.4 ) ( EC 2.7.1.4 ) β-/β- ( EC 3.2.1.21 ) ( EC 3.2.1.37 ) β-/β- ( EC 3.2.1.21 ) ( EC 3.2.1.37 ) 2- ( EC 1.1.1.67 ) ( EC 1.1.1.-) - ( EC 1.1.99.28 ) - ( EC 1.1.99.28 ) - ( EC 1.1.99.28 ) -6- ( EC 3.2.1.26 ) -6- ( EC 3.2.1.26 ) -6- ( EC 3.2.1.26 ) -6- ( EC 5.3.1.8 ) -6- ( EC 5.3.1.8 ) -6- ( EC 5.3.1.8 ) 1； 4-α- ( EC 2.4.1.18 ) 1,4-α- ( EC 2.4.1.18 ) ( EC 2.4.1.25 ) ( EC 3.2.1.33 ) ( EC 2.4.1.25 ) ( EC 3.2.1.33 ) GLGX ( EC 3.2.1.-) ( EC 2.4.1.1 ) ( EC 2.4.1.1 ) ( EC 2.4.1.1 ) ( EC 2.4.1.1 ) ( EC 2.4.1.1 ) α- ( EC 3.2.1.1 ) G1G2 ( EC 3.2.1.3 ) ( EC 2.7.1.17 ) ( EC 2.7.1.17 ) ( EC 2.7.1.15 ) ( EC 2.7.1.15 ) 6--β- ( EC 3.2.1.86 ) - ( EC 4.1.2.4 ) 1--D-5- ( EC 1.1.1.-) 1--D-5- ( EC 1.1.1.-)

Table 1 (continuing)

Nucleic acid SEQ ID NO	Amino acid SEQ ID NO	Identification code	Contig	NT is initial	NT stops	Function
							403 405 407 409 411 413 415 417 419 421 423 425 427 429 431 433 435 437 439 441 443 445 447 449 451 453 455 457 459 461 463 465 467 469 471 473 475 477 479	404 406 408 410 412 414 416 418 420 422 424 426 428 430 432 434 436 438 440 442 444 446 448 450 452 454 456 458 460 462 464 466 468 470 472 474 476 478 480	RXN01562 FRXA01562 FRXA01705 RXN00879 FRXA00879 RXN00043 FRXA00043 RXN01752 FRXA01839 RXA01859 RXA00042 RXA01482 RXN03179 FRXA02872 RXN03180 FRXA02873 RXA02292 RXA02666 RXA00202 RXA02440 RXN01569 FRXA01569 FRXA02055 RXA00825 RXA02054 RXN00427 FRXA00427 RXA00327 RXA00328 RXA00329 RXN01554 RXN03015 RXN03056 RXN03030 RXN00401 RXN02125 RXN00200 RXN01175 RXN01376	VV0191 GR00436 GR00480 VV0099 GR00242 VV0119 GR00007 VV0127 GR00520 GR00529 GR00007 GR00422 VV0336 GR10013 VV0337 GR10014 GR00662 GR00753 GR00032 GR00709 VV0009 GR00438 GR00624 GR00222 GR00624 VV0112 GR00098 GR00057 GR00057 GR00057 VV0135 VV0063 VV0028 VV0009 VV0025 VV0102 VV0181 VV0017 VV0091	1230 2 971 8763 5927 3244 3244 35265 1157 1473 2037 17271 2 675 672 672 1611 7260 1216 5097 41086 2 7122 222 6103 7004 1591 10263 11147 12390 28686 289 6258 57006 12427 23242 1679 39688 5610	3137 1039 1573 6646 3828 2081 2081 33805 510 547 1279 15397 667 4 163 163 2285 6493 275 4258 42444 427 8042 1154 7119 6219 2022 9880 10656 11167 26545 8 6935 56443 11489 22442 5116 38303 4750	1-deoxy-D-xylulose sugar-5-phosphate synthase 1-deoxy-D-xylulose sugar-5-phosphate synthase 1-deoxy-D-xylulose sugar-5-phosphate synthase 4-alpha-Glucanotransferase (EC 2.4.1.25) 4-alpha-Glucanotransferase (EC 2.4.1.25); Amylomaltase N-acetyl-glucosamine-6-phosphoric acid deacetylase (EC 3.5.1.25) N-acetyl-glucosamine-6-phosphoric acid deacetylase (EC 3.5.1.25) N-acetyl-glucosamine transferase (EC 2.4.1.-) N-acetyl-glucosamine transferase (EC 2.4.1.-) N-acetyl-glucosamine transferase (EC 2.4.1.-) glucosamine-6-phosphate isomerase (EC 5.3.1.10) aminoglucose-fructose-6-phosphate aminopherase (isomerization) (EC 2.6.1.16) uronic isomerase (EC 5.3.1.12) uronic isomerase; Glucuronate isomerase (EC 5.3.1.12) uronic isomerase (EC 5.3.1.12) uronic isomerase; Glucuronate isomerase, (EC 5.3.1.12) galactoside O-transacetylase, (EC 2.3.1.18) D-ribose alcohol-5-cytidine phosphate acyltransferase, (EC 2.7.7.40) D-ribose-in conjunction with periplasm protein precursor D-ribose-in conjunction with periplasm protein precursor dTDP-4-dehydrogenation rhamnose reductase, (EC 1.1.1.133) DTDP-4-dehydrogenation rhamnose reductase, (EC 1.1.1.133) DTDP-4-dehydrogenation rhamnose reductase, (EC 1.1.1.133) DTDP-glucose 4; 6-dehydratase (EC 4.2.1.46) DTDP-glucose 4,6-dehydratase (EC 4.2.1.46) dTDP-rhamnose transferase RFBF (EC 2.-.-.-) DTDP-rhamnose transferase RFBF (EC 2.-.-.-) a-protein RAJ a-protein RAJ a-protein RAJ glucan inscribe-1.3-β-glucosyl enzym A1 precursor (EC 3.2.1.39) UDPG 6-dehydrogenase (EC 1.1.1.22) is inferred ketohexose-6-phosphoric acid isomerase (EC 5.-.-.-) pericentral siphon β-glucosyl enzym/xylobiase precursor (EC 3.2.1.21) (EC 3.2.1.37) 5-Dehydro-4-deoxyglucarate dehydratase (EC 4.2.1.41) aldose reductase (EC 1.1.1.21) the arabinose transferase B of subunit (EC 2.4.2.-) phospho-2-dehydro-3-deoxyheptonate aldolase (EC 4.1.2.15) and is inferred glycosyl transferase WBIF

Table 1 (continuing)

Nucleic acid SEQ ID NO	Amino acid SEQ ID NO	Identification code	Contig	NT is initial	NT stops	Function
							481 483 485 487 489 491 493 495 497 499 501 503 505 507 509 511 513 515 517 519 521 523 525 527 529 531 533 535 537 539 541 543	482 484 486 488 490 492 494 496 498 500 502 504 506 508 510 512 514 516 518 520 522 524 526 528 530 532 534 536 538 540 542 544	RXN01631 RXN01593 RXN00337 RXS00584 RXS02574 RXS03215 FRXA01915 RXS03224 FRXA00038 RXC00233 RXC00236 RXC00271 RXC00338 RXC00362 RXC00412 RXC00526 RXC01004 RXC01017 RXC01021 RXC01212 RXC01306 RXC01366 RXC01372 RXC01659 RXC01663 RXC01693 RXC01703 RXC02254 RXC02255 RXC02435 FRXA02435 RXC03216	VV0050 VV0229 VV0197 VV0323 GR00549 GR00006 GR00709?	47021 13274 20369 5516 1 1417 825?	46143 12408 21418 6640 1008 260 268?	-6- ( EC 5.-.-.-) NAGD ( EC 2.7.1.6 ) -2--3- ( EC 4.1.2.15 ) β-A ( EC 3.2.1.52 ) - ( EC 1.1.99.28 ) - ( EC 1.1.99.28 ) ( EC 3.2.1.54 ) ( EC 3.2.1.54 ) ABCATP ABCATP ABCATP ( rhomboid )
The TCA-circulation
	Nucleic acid SEQ ID NO	Amino acid SEQ ID NO	Identification code	Contig	NT is initial	NT stops	Function
545 547								546 548	RXA02175 RXA02621	GR00641 GR00746	10710 2647	9418 1829	Oxalacetic transacetase (EC 4.1.3.7) citrate lyase β chain (EC 4.1.3.6)

Table 1 (continuing)

Nucleic acid SEQ ID NO	Amino acid SEQ ID NO	Identification code	Contig	NT is initial	NT stops	Function
							549 551 553 555 557 559 561 563 565 567 569 571 573 575 577 579 581 583 585 587	550 552 554 556 558 560 562 564 566 568 570 572 574 576 578 580 582 584 586 588	RXN00519 FRXA00521 RXN02209 FRXA02209 RXN02213 FRXA02213 RXA0256 RXA01745 RXA00782 RXA00783 RXN01695 FRXA01615 FRXA01695 RXA00290 RXN01048 FRXA01048 FRXA00290 RXN03101 RXN02046 RXN00389	VV0144 GR00133 VV0304 GR00648 VV0305 GR00649 GR00625 GR00495 GR00206 GR00206 VV0139 GR00449 GR00474 GR00046 VV0079 GR00296 GR00046 VV0066 VV0025 VV0025	5585 2 1 3 1378 1330 3 2 3984 5280 11307 8608 4388 4693 12539 3 4693 2 15056 11481	3372 1060 1671 1661 2151 2046 2870 1495 3103 4009 12806 9546 4179 5655 11316 290 5655 583 14640 9922	( NADP ) ( EC 1.1.1.42 ) ( NADP ) ( EC 1.1.1.42 ) ( EC 4.2.1.3 ) ( EC 4.2.1.3 ) ( EC 4.2.1.3 ) ( EC 4.2.1.3 ) 2-E1 ( EC 1.2.4.2 ) 2- ( E2 ) ( EC 2.3.1.61 ) -CoAα ( EC 6.2.1.5 ) -CoAβ ( EC 6.2.1.5 ) L- ( ) ( EC 1.1.99.16 ) L- ( ) ( EC 1.1.99.16 ) L- ( ) ( EC 1.1.99.16 ) ( EC 1.1.1.39 ) ( EC 1.1.1.39 ) ( EC 1.1.1.39 ) ( EC 1.1.1.39 ) 2- ( E2 ) ( EC 2.3.1.61 ) 2- ( EC 2.3.1.61 ) ( EC 1.2.1.-)
Glyoxylate bypass
	Nucleic acid SEQ TD NO	Amino acid SEQ ID NO	Identification code	Contig	NT is initial	NT stops	Function
589 591 593 595 597 599								590 592 594 596 598 600	RXN02399 FRXA02399 RXN02404 FRXA02404 RXA01089 RXA01886	VV0176 GR00699 VV0176 GR00700 GR00304 GR00539	19708 478 20259 3798 3209 3203	18365 1773 22475 1663 3958 2430	Isocitrate lyase (EC 4.1.3.1) isocitrate lyase (EC 4.1.3.1) malate synthase (EC 4.1.3.2) malate synthase (EC 4.1.3.2) oxoethanoic acid inducible protein oxoethanoic acid inducible protein
	The methyl citrate approach
Nucleic acid SEQ ID NO		Amino acid SEQ ID NO	Identification code	Contig	NT is initial	NT stops	Function
	600 601 603 605							602 604 606 608	RXN03117 FRXA00406 FRXA00514 RXA00512	VV0092 GR00090 GR00130 GR00130	3087 978 1983 621	1576 4 1576 4	2-methyl isocitrate lyase (EC 5.3.3.-) 2-methyl isocitrate lyase (EC 5.3.3.-) 2-methyl isocitrate lyase (EC 5.3.3.-) 2-Methylcitrate synthase (EC 4.1.3.31)

Table 1 (continuing)

Nucleic acid SEQ ID NO	Amino acid SEQ ID NO	Identification code	Contig	NT is initial	NT stops	Function
							607 609 611 613 615 617 619 621 623	?610?612?614?616?618?620?622?624?626	RXA00518 RXA01077 RXN03144 FRXA02322 RXA02329 RXA02332 RXN02333 FRXA02333 RXA00030	GR00131 GR00300 VV0141 GR00668 GR00669 GR00671 VV0141 GR00671 GR00003	3069 4647 2 415 607 1906 901 2120 9590	2773 6017 901 5 5 764 1815 1902 9979	2-Methylcitrate synthase (EC 4.1.3.31) 2-methyl isocitrate lyase (EC 5.3.3.-) 2-methyl isocitrate lyase (EC 5.3.3.-) 2-methyl isocitrate lyase (EC 5.3.3.-) 2-methyl isocitrate lyase (EC 5.3.3-) 2-Methylcitrate synthase (EC 4.1.3.31) isocitric acid methyl esters lyase (EC 4.1.3.30) isocitric acid methyl esters lyase (EC 4.1.3.30) lactylglutathion lyase (EC 4.4.1.5)
Methyl-malonyl--CoA-mutase
	Nucleic acid SEQ ID NO	Amino acid SEQ ID NO	Identification code	Contig	NT is initial	NT stops	Function
625 627 629								?628?630?632	RXN00148 FRXA00148 RXA00149	VV0167 GR00023 GR00023	9849 2002 3856	12059 5 2009	Methylmalonyl-CoA mutase α-subunit (EC 5.4.99.2) methylmalonyl-CoA mutase α-subunit (EC 5.4.99.2) methylmalonyl-CoA mutase beta subunit (EC 5.4.99.2)
	Other
Nucleic acid SEQ ID NO		Amino acid SEQ ID NO	Identification code	Contig	NT is initial	NT stops	Function
	631 635 637 639							?634?636?638?640	RXN00317 FRXA00317 RXA02196 RXN02461	VV0197 GR00055 GR00645 VV0124	26879 344 3956 14236	27532 6 3264 14643	Phosphoglycolate phosphatase (EC 3.1.3.18) phosphoglycolate phosphatase (EC 3.1.3.18) phosphoglycolate phosphatase (EC 3.1.3.18) phosphoglycolate phosphatase (EC 3.1.3.18)
The redox chain
	Nucleic acid SEQ ID NO	Amino acid SEQ ID NO	Identification code	Contig	NT is initial	NT stops	Function
641 643 645 647 649 651 653 655 657 659								?642?644?646?648?650?652?654?656?658?660	RXN01744 FRXA00055 FRXA01744 RXA00379 RXA00385 RXA01743 RXN02480 FRXA01919 FRXA02480 FRXA02481	VV0174 GR00008 GR00494 GR00082 GR00083 GR00494 VV0084 GR00550 GR00717 GR00717	2350 11753 2113 212 773 806 31222 288 1449 1945	812 11890 812 6 435 6 29567 4 601 1334	Biological biological PROTEIN C CDA cytochromes D ubiquinol oxidase subunit II (EC 1.10.3.-) cytochrome c oxidase polypeptide I (EC 1.9.3.1) cytochrome C oxidase subunit I (EC 1.9.3.1) cytochrome C oxidase polypeptide I (EC 1.9.3.1) the cytochrome C oxidase polypeptide I (EC 1.9.3.1) of generation of PROTEIN C CDA cromoci type that occur of cytochromes D ubiquinol oxidase subunit I (EC 1.10.3.-) cytochromes D ubiquinol oxidase subunit I (EC 1.10.3.-) cytochromes D ubiquinol oxidase subunit I (EC 1.10.3.-) cromoci type

Table 1 (continuing)

Nucleic acid SEQ ID NO	Amino acid SEQ ID NO	Identification code	Contig	NT is initial	NT stops	Function
							?661?663?665?667?669?671?673?675?677?679?681?683?685?687?689?691?693?695?697?699?701?703?705?707?709?711?713?715?717?719?721?723?725?727?729?731?733?735	662664666668670672674676678680682684686688690692694696698700702704706708710712714716718720722734726728730732734736	RXA02140 RXA02142 RXA02144 RXA02740 RXA02743 RXA01227 RXA01865 RXA00680 RXA00679 RXA00224 RXA00225 RXN00606 FRXA00606 RXN00595 FRXA00608 RXA00913 RXA00909 RXA00700 RXN00483 FRXA00483 RXA01534 RXA00288 RXA02741 RXN02560 FRXA02560 RXA01311 RXN03014 FRXA00910 RXN01895 FRXA01895 RXA00703 RXN00705 FRXA00705 RXN00388 FRXA00388 FRXA00386 RXA00945 RXN02556	GR00639 GR00639 GR00639 GR00763 GR00763 GR00355 GR00532 GR00179 GR00179 GR00032 GR00032 VV0192 GR00160 VV0192 GR00160 GR00249 GR00247 GR00182 VV0086 GR00119 GR00427 GR00046 GR00763 VV0101 GR00731 GR00380 VV0058 GR00248 VV0117 GR00543 GR00183 VV0005 GR00184 VV0025 GR00085 GR00084 GR00259 VV0101	7339 9413 11025 7613 13534 1199 436 2632 2302 24965 25783 11299 121 8642 2253 3 2552 846 44824 19106 1035 2646 9585 9922 6339 1611 1273 3 955 2 2556 6111 1291 2081 969 514 1876 5602	8415 10063 12248 8542 12497 1519 122 2315 1037 24015 24998 9026 1869 7113 3017 2120 3406 43 46287 20569 547 1636 8620 10788 7160 865 368 1259 5 817 271 5197 407 3091 667 5 2847 6759	CII ( EC 1.9.3.1 ) CI ( EC 1.9.3.1 ) RIESKE C AA3 VI -NAD ( + ) ( EC 1.18.1.3 ) α- β- NADHIL ( EC 1.6.5.3 ) NADHIL ( EC 1.6.5.3 ) NADHIM ( EC 1.6.5.3 ) NADHIM ( EC 1.6.5.3 ) NADHIL ( EC 1.6.5.3 ) NADHIL ( EC 1.6.5.3 ) NADH-2 NADH-39KD ( EC 1.6.5.3 ) ( EC 1.6.99.3 ) NADH-39KD ( EC 1.6.5.3 ) ( EC 1.6.99.3 ) NADHFMN ( EC 1.6.5.5 ) ( EC 1.6.5.5 ) NADPH- ( EC 1.6.99.-) NADPH- ( EC 1.6.99.-) ( EC 1.3.99.1 ) NADHIM ( EC 1.6.5.3 ) NADH ( EC 1.6.99.3 ) α ( EC 1.2.1.2 ) FDHD FDHD CCSA c RESC,c / ( EC 1.6.99.7 )

Table 1 (continuing)

Nucleic acid SEQ ID NO	Amino acid SEQ ID NO	Identification code	Contig	NT is initial	NT stops	Function
							737 739 741 743 745 747 749 751 753	738 740 742 744 746 748 750 752 754	FRXA02556 RXA01392 RXA00800 RXA02143 RXN03096 RXN02036 RXN02765 RXN02206 RXN02554	GR00731 GR00408 GR00214 GR00639 VV0058 VV0176 VV0317 VV0302 VV0101	2019 2297 2031 10138 405 32683 3552 1784 4633	3176 3373 3134 11025 4 33063 2794 849 4010	Flavine reduced hematin glutathione S-transferase (EC 2.5.1.18) Triptide dependency formaldehyde dehydrogenase (EC 1.2.1.1) QCRC albumen: vitamin k4 alcohol: cytochrome c oxydo-reductase nadh dehydrogenase I chain M (EC 1.6.5.3) NADH-ubiquinone oxide-reductase enzyme chain 4 (EC 1.6.5.3) supposition oxydo-reductase supposition oxydo-reductase supposition oxydo-reductase (EC 1.1.1.-)
The ATP-synthase
	Nucleic acid SEQ ID NO	Amino acid SEQ ID NO	Identification code	Contig	NT is initial	NT stops	Function
755 757 759 761 763 765 767 769 771 773 775 777								756 758 760 762 764 766 768 770 772 774 776 778	RXN01204 FRXA01204 RXA01201 RXN01193 FRXA01193 FRXA01203 RXN02821 FRXA02821 RXA01200 RXA01194 RXA01202 RXN02434	VV0121 GR00345 GR00344 VV0175 GR00343 GR00344 VV0121 GR00802 GR00344 GR00343 GR00344 VV0090	1270 394 675 5280 15 3355 324 139 770 2375 4923	461 1155 2315 3832 755 3993 85 318 610 1141 3349 3274	Atp synthase A chain, (EC 3.6.1.34) atp synthase A chain, (EC 3.6.1.34) atp synthase α chain, (EC 3.6.1.34) atp synthase β chain, (EC 3.6.1.34) atp synthase β chain, (EC 3.6.1.34) atp synthase β chain, (EC 3.6.1.34) atp synthase C chain, (EC 3.6.1.34) atp synthase C chain, (EC 3.6.1.34) atp synthase δ chain, (EC 3.6.1.34) atp synthase ε chain, (EC 3.6.1.34) atp synthase γ chain, (EC 3.6.1.34) ATP is conjugated protein
	The cytopigment metabolism
Nucleic acid SEQ ID NO		Amino acid SEQ ID NO	Identification code	Contig	NT is initial	NT stops	Function
	779 781							780 782	RXN00684 RXN00387	VV0005 VV0025	29864 1150	28581 2004	The biological albumen that takes place of Cytochrome P450 116 (EC 1.14.-.-) supposition cytochrome c

The gene that table 2-gets rid of
	GenBank TMRegistration number	The gene title	Gene function	Reference
A09073					ppg	Phosphoenolpyruvate carboxylase	Bachmann, B. etc. " dna fragmentation of coding Phosphoenolpyruvate carboxylase, carry described segmental recombinant DNA, have the bacterial strain of described recombinant DNA and adopt described bacterial strain to produce the amino acid whose method of L-", patent: EP 0358940-A 03/21/90
	A45579， A45581， A45583， A45585 A45587		Threonine dehydra(ta)se	Moeckel, B. etc. " utilization has the recombinant microorganism of regulating threonine dehydra(ta)se and produces the L-Isoleucine " patent: WO 9519442-A 5 07/20/95
AB003132					murC；ftsQ；ftsZ		Kobayashi, M. etc. " clone, order-checking and the evaluation of excellent bacillus ftsZ gene " Biochem.Biophys.Res. Commnn., 236 (2): 383-388 (1997)
	AB015023	murC；ftsQ		Wachi, M. etc. " the marC gene of excellent bacillus " Appl.Microbiol.Biotechnol., 51 (2): 223-228 (1999)
AB018530					dtsR		Kimura, E. etc. " to the molecular cloning of rescue ", Biosci.Biotechnol.Biochem., 60 (10): 1565-1570 (1996) derived from the novel gene dtsR of the washing agent susceptibility of the mutant of brevibacterium
	AB018531	dtsR1；dtsR2
AB020624					murl	The D-glutamate racemase
	AB023377	tkt	Transketolase

Table 2 (continuing)
	AB024708	?gltB；gltD	Big subunit of glutamine 2-oxoglutaric acid transaminase and small subunit
AB025424					?acn	Aconitase
	AB027714	?rep	Replication protein
AB027715					?rep；aad	Replication protein; Aminoglycoside adenylic acid (AMP) transferring enzyme
	AF005242	?argC	N-acetylglutamat-5-semialdehyde desaturase
AF005635					?glnA	Glutamine synthetase
	AF030405	?hisF	Cyclase
AF030520					?argG	Argininosuccinate synthetase
	AF031518	?argF	Ornithine carbamyl transferase
AF036932					?aroD	The 3-dehydroquinate dehydratase
	AF038548	?pyc	Pyruvate carboxylase
AF038651					?dciAE；apt；rel	Two peptide-binding proteins; Adenine phosphoribosyltransferase; The GTP pyrophosphokinase	Wehmeier, L. etc. " effect of Corynebacterium glutamicum rel gene in (p) ppGpp metabolism ", Microbiology, 144:1853-1862 (1998)
	AF041436	?argR	The arginine repressor
AF045998					?impA	The inositol monophosphate Phosphoric acid esterase
	AF048764	?argH	The argininosuccinic acid lyase

Table 2 (continuing)
	AF049897	argC；argJ；argB； argD；argF；argR； argG；argH	N-acetyl glutamy phosphoric acid reduction enzyme; The ornithine acetyltransferase; The N-acetylglutamat kinases; Acetyl-ornithine transaminase; Ornithine carbamyl transferase; The arginine repressor; The argininosuccinic acid synthase; The argininosuccinic acid lyase
AF050109					inhA	Enol-acyl carrier protein reductase enzyme
	AF050166	hisG	ATP phosphoribosyltransferase
AF051846					hisA	Ribose phosphoric acid formyl imino--5-amino-ribose 1-phosphate base-4-Imidazole carboxamide isomerase
	AF052652	metA	Homoserine O-acetyltransferase	Park, S. etc. " separation and the analysis of the methionine(Met) biosynthesis gene of coding homoserine acetyltransferase in metA-Corynebacterium glutamicum ", Mol.Cell., 8 (3): 286-294 (1998)
AF053071					aroB	The dehydroquinic acid synthetic enzyme
	AF060558	hisH	The glutamine transamidase
AF086704					hisE	Phosphoribosyl-ATP-pyrophosphohydrolase
	AF114233	aroA	5-enol pyruvic acid shikimic acid 3-phosphate synthase
AF116184					panD	L-aspartic acid-α-decarboxylase precursor	Dusch, N. etc. " the Corynebacterium glutamicum panD expression of gene of coding L-aspartic acid-α-decarboxylase causes intestinal bacteria excessively to produce pantothenic acid ", Appl.Environ.Microbiol., 65 (4) 1530-1539 (1999)
	AF124518	aroD；aroE	3-dehydroquinase (dehydroquinase); Shikimate dehydrogenase

Table 2 (continuing)
	AF124600	?aroC；aroK；aroB；?pepQ	Chorismate synthase; Shikimate kinase; 3-Dehydroquinate synthase; The kytoplasm peptase of inferring
AF145897					?inhA
	AF145898	?inhA
AJ001436					?ectP	The transhipment of ectoine, trimethyl-glycine, proline(Pro)	Peter, H etc. " Corynebacterium glutamicum has second carrier of four kinds of coupling solutes: evaluation, order-checking and the sign of proline(Pro)/ectoine shooting system Prop and ectoine/ proline(Pro)/trimethyl-glycine carrier EctP ", J. Bacteriol., 180 (22): 6005-6012 (1998)
	AJ004934	?dapD	Tetrahydrochysene 2, dipicolimic acid 2 succinylation enzyme is (incomplete i)	Wehrmann, A. etc. " the synthetic and effect aspect the cell walls integrity of the diaminopimelic acid of different mode: the research of carrying out with Corynebacterium glutamicum ", J.Bacteriol., 180 (12); 3159-3165 (1998)
AJ007732					?ppc；secG；amt；ocd；?soxA	Phosphoenolpyruvate carboxylase; The high affinity ammonium is taken in albumen; The ornithine of inferring-ring decarboxylase; Sarcosine oxidase
	AJ010319	?ftsY，glnB，glnD；srp；?amtP	Participate in cell fission; PH albumen; Uridyl transferase (uridine acyl group removing enzyme); Signal recognition particle; Low affinity ammonium is taken in albumen	Jakoby, M. etc. " regulate by the nitrogen in the Corynebacterium glutamicum; Relate to the separation of the biological chemistry genes identified of respective egg white matter ", FEMS Microbiol, 173 (2): 303-310 (1999)
AJ132968					?cat	Chloramphenicol acetyltransferase
	AJ224946	?mqo	L MALIC ACID; Quinone oxidoreductase	Molenaar, D. etc. the biological chemistry and the genetics characterized of malate dehydrogenase (malic acid dehydrogenase) (acceptor) " the Corynebacterium glutamicum film be correlated with ", Eur.J.Biochem., 254 (2): 395-403 (1998)
AJ238250					?ndh	Nadh dehydrogenase

Table 2 (continuing)
	AJ238703	porA	Porin	Lichtinger, T. etc. " biological chemistry of Corynebacterium glutamicum cell envelope porin and biophysics characterized: this passage is formed by low molecular weight polypeptide ", Biochemistry, 37 (43): 15024-15032 (1998)
D17429						Transposable element IS31831	Vertes etc. " derive from separation and the characterized of the transposable element IS31831 of Corynebacterium glutamicum ", Mol. Microbiol., 11 (4): 739-746 (1994)
	D84102	odhA	The 2-oxoglutaric acid desaturase	Usuda, Y. etc. " molecular cloning of the Corynebacterium glutamicum of encoding novel 2-oxoglutaric acid desaturase (brevibacterium AJ12036) odhA gene ", Microbiology, 142:3347-3354 (1996)
E01358					hdh；hk	Homoserine dehydrogenase; Homoserine kinase	Katsumata, R. etc. " production of L-Threonine and L-Isoleucine ", patent: JP 1987232392-A 210/12/87
	E01359		The upstream of homoserine kinase gene start codon	Katsumata, R. etc. " production of L-Threonine and L-Isoleucine ", patent t:JP 1987232392-A 210/12/87
E01375						Tryptophan operon
	E01376	trpL；trpE	Leading peptide; The o-amino benzoyl acid synthase	Matsui, K. etc. " tryptophan operon, by peptide and protein, the utilization of tryptophan operon genetic expression and the production of tryptophane of its coding ", patent: JP 1987244382-A 1 10/24/87
E01377						The promotor of tryptophan operon and operator region	Matsui, K. etc. " tryptophan operon, by peptide and protein, the utilization of tryptophan operon genetic expression and the production of tryptophane of its coding ", patent: JP 1987244382-A 1 10/24/87
	E03937		The vitamin H synthase	Hatakeyama, K. etc. the dna fragmentation and the application thereof of gene of plain synthetic enzyme " contain can encoding human ", patent: JP 1992278088-A 1 10/02/92
E04040						Diamino pelargonic amino transferase	Kohama, K. etc. " gene and the application thereof of coding diaminopimelic acid transaminase and dethiobiotin synthetase ", patent: JP 1992330284-A 1 11/18/92

Table 2 (continuing)
	E04041		Dethiobiotin synthetase	Kohama, K. etc. " gene and the application thereof of coding diaminopimelic acid transaminase and dethiobiotin synthetase ", patent: JP 1992330284-A 1 11/18/92
E04307						The Flavum L-Aspartase	Kurusu, Y. etc. " gene DNA and the application thereof of coding L-Aspartase ", patent: JP 1993030977-A 1 02/09/93
	E04376		Isocitrate lyase	Katsumata, R. etc. " gene shows controlled DNA ", patent: JP 1993056782-A 3 03/09/93
E04377						Isocitrate lyase N-terminal fragment	Katsumata, R. etc. " gene shows controlled DNA ", patent: JP 1993056782-A 3 03/09/93
	E04484		Prephenate dehydratase	Sotouchi, N. etc. " by fermentative production L-phenylalanine ", patent: JP 1993076352-A 2 03/30/93
E05108						E.C. 2.7.2.4.	Fugono, N. etc. " gene DNA and the application thereof of coding E.C. 2.7.2.4. ", patent: JP 1993184366-A 1 07/27/93
	E05112		Dihydro-dipichorinate synthetic enzyme	Hatakeyama, K. etc. " coding dihydro 2, the gene DNA of dipicolimic acid 2 synthetic enzyme and application thereof ", patent: JP 1993184371-A 1 07/27/93
E05776						Diaminopimelate dehydrogenase	Kobayashi, M. etc. " gene DNA and the application thereof of coding diaminopimelate dehydrogenase ", patent: JP 1993284970-A 1 11/02/93
	E05779		Threonine synthase	Kohama, K. etc. " gene DNA and the application thereof of coding threonine synthase ", patent: JP 1993284972-A 1 11/02/93
E06110						Prephenate dehydratase	Kikuchi, T. etc. " by fermentative Production L-phenylalanine ", patent: JP 1993344881-A 1 12/27/93
	E06111		The mutant prephenate dehydratase	Kikuchi, T. etc. " by fermentative Production L-phenylalanine ", patent: JP 1993344881-A 1 12/27/93

Table 2 (continuing)
	E06146		Acetohydroxy acid synthetase	Inui, M. etc. " gene and the application thereof of the acetohydroxy acid synthetase of can encoding ", patent: JP 1993344893-A 1 12/27/93
E06825						E.C. 2.7.2.4.	Sugimoto, M. etc. " mutant aspartokinase gene ", patent: JP 1994062866-A 1 03/08/94
	E06826		Mutant E.C. 2.7.2.4. α subunit	Sugimoto, M. etc. " mutant aspartokinase gene ", patent: JP 1994062866-A 1 03/08/94
E06827						Mutant E.C. 2.7.2.4. α subunit	Sugimoro, M. etc. " mutant aspartokinase gene ", patent: JP 1994062866-A 1 03/08/94
	E07701	secY		Honno, N etc. " participate in the gene DNA that membranin is integrated into film ", patent: JP 1994169780-A 1 06/21/94
E08177						E.C. 2.7.2.4.	Sato, Y. etc. " can encoder feedback suppress the hereditary DNA and the application thereof of the E.C. 2.7.2.4. that discharges ", patent: JP 1994261766-A 1 09/20/94
	E08178， E08179， E08180， E08181， E08182		The E.C. 2.7.2.4. that feedback inhibition discharges	Sato, Y. etc. " can encoder feedback suppress the hereditary DNA and the application thereof of the E.C. 2.7.2.4. that discharges ", patent: JP 1994261766-A 1 09/20/94
E08232						Acetohydroxy acid isomeroreductase	Inui, M. etc. " gene DNA of coding acetohydroxy acid isomeroreductase ", patent: JP 1994277067-A 10/04/94

Table 2 (continuing)
	E08234	secE		Asai, Y. etc. " gene DNA of coded protein transporting mechanism ", patent: JP 1994277073-A 1 10/04/94
E08643						FT transaminase and dethiobiotin synthetase promoter region	Harakeyama, K. etc. " dna fragmentation that has promoter function in the excellent bacillus ", patent: JP 1995031476-A 1 02/03/95
	E08646		The vitamin H synthetic enzyme	Hatakeyama, K. etc. " dna fragmentation that has promoter function in the excellent bacillus ", patent: JP 1995031476-A 1 02/03/95
E08649						L-Aspartase	Kohama, K. etc. " dna fragmentation that has promoter function in the excellent bacillus ", patent: JP 1995031478-A 1 02/03/95
	E08900		Dihydro 2, the dipicolimic acid 2 reductase enzyme	Madori, M. etc. " contain coding dihydro 2, the dna fragmentation of the gene of dipicolimic acid 2 reductase enzyme and application thereof ", patent: JP 1995075578-A 1 03/20/95
E08901						Diaminapimelate decarboxylase	Madori, M. etc. " contain the dna fragmentation and the application thereof of the gene of coding dihydro pimelic acid decarboxylase ", patent: JP 1995075579-A 1 03/20/95
	E12594		Serine hydroxymethylase	Hatakeyama, K. etc. " production of L-tryptophane ", patent: JP 1997028391-A 1 02/04/97
E12760， E12759， E12758						Transposase	Moriya, M. etc. " adopt the artificial transposon amplification gene ", patent: JP 1997070291-A 03/18/97
	E12764		Arginyl-tRNA synthetase; Diaminapimelate decarboxylase	Moriya, M. etc. " adopt the artificial transposon amplification gene ", patent: JP 1997070291-A 03/18/97
E12767						Dihydro 2, the dipicolimic acid 2 synthetic enzyme	Moriya, M. etc. " adopt the artificial transposon amplification gene ", patent: JP 1997070291-A 03/18/97
	E12770		E.C. 2.7.2.4.	Moriya, M. etc. " adopt the artificial transposon amplification gene ", patent: JP 1997070291-A 03/18/97

Table 2 (continuing)
	E12773		Dihydro 2, the dipicolimic acid 2 reductase enzyme	Moriya, M. etc. " adopt the artificial transposon amplification gene ", patent: JP 1997070291-A 03/18/97
E13655						Glucose-6-phosphate dehydrogenase (G6PD)	Hatakeyama, K. etc. " glucose-6-phosphate dehydrogenase (G6PD) and its DNA of can encoding ", patent: JP 1997224661-A 1 09/02/97
	L01508	IlvA	Threonine dehydra(ta)se	Moeckel, B. etc. " function of Corynebacterium glutamicum threonine dehydra(ta)se and structural analysis ", J.Bacteriol., 174:8065-8072 (1992)
L07603					EC?4.2.1.15	The Arabic heptanone saccharic acid of 3-deoxidation-D--7-phosphate synthase	Chen, C. etc. " clone and the nucleotide sequence of the Arabic heptanone saccharic acid of Corynebacterium glutamicum 3-deoxidation-D--7-phosphate synthase gene ", FEMS Microbiol.Lett., 107:223-230 (1993)
	L09232	IlvB；ilvN；ilvC	The big subunit acetohydroxy acid synthase of acetohydroxy acid synthase small subunit; Acetohydroxy acid isomeroreductase	Keilhauer, C. etc. " Isoleucine in the Corynebacterium glutamicum is synthetic: the analysis of molecules of ilvB-ilvN-ilvC operon ", J.Bacteriol., 175 (17): 5595-5603 (1993)
L18874					PtsM	The phosphoenolpyruvic acid sugar phosphotransferase	Fouet, A etc. " the sucrose specific enzymes II of Bacillus subtilus phosphotransferase system: the expression in intestinal bacteria and with the homology of enterobacteria enzyme II ", PNAS USA, 84 (24): 8773-8777 (1987); Lee, J.K. etc. " analysis of the nucleotide sequence of the gene of coding Corynebacterium glutamicum seminase II and the protein sequence of derivation ", FEMS Microbiol.Lett., 119 (1-2): 137-145 (1994)
	L27123	aceB	Malate synthase	Lee, H-S. etc. " characterization of molecules of the gene of coding malate synthase is identified in aceB-Corynebacterium glutamicum ", J.Microbiol.Biotechnol., 4 (4): 256-263 (1994)
L27126						Pyruvate kinase	Jetten, M.S. etc. " structure of Corynebacterium glutamicum pyruvate kinase and functional analysis ", Appl. Environ.Microbiol., 60 (7): 2501-2507 (1994)
	L28760	aceA	Isocitrate lyase
L35906					dtxr	The diphtheria toxin repressor	Oguiza, J.A. etc. " from molecular cloning, dna sequence analysis and the characterized of the corynebacterium diphtheriae dtxR of brevibacterium ", J.Bacteriol., 177 (2): 465-467 (1995)

Table 2 (continuing)
	M13774		Prephenate dehydratase	Follettie, M.T. etc. " molecular cloning and the nucleotide sequence of Corynebacterium glutamicum pheA gene ", J. Bacteriol., 167:695-702 (1986)
M16175					5S?rRNA		Park, Y-H. etc. " analyze the kind system that excellent bacillus carries out by 56 kinds of rRNA sequences ", J. Bacteriol., 169:1801-1806 (1987)
	M16663	trpE	The o-amino benzoyl acid synthase, 5 ' end	Sano, K etc. " a kind of L-glutamic acid is produced the 26S Proteasome Structure and Function of bacterium-brevibacterium trp operon control region ", Gene, 52:191-200 (1987)
M16664					trpA	Tryptophan synthetase, 3 ' end	Sano, K. etc. " a kind of L-glutamic acid is produced the 26S Proteasome Structure and Function of bacterium-brevibacterium trp operon control region ", Gene, 52:191-200 (1987)
	M25819		Phosphoenolpyruvate carboxylase	O ' Regan, M etc. " clone and the nucleotide sequence of the Phosphoenolpyruvate carboxylase encoding gene of Corynebacterium glutamicum ATCC13032 ", Gene, 77 (2): 237-251 (1989)
M85106						23S rRNA gene insertion sequence	Roller, C. etc. " there be common the insertion in being characterized as of gram positive bacterium with high DNA G+C content in its 23S rRNA gene ", J.Gen.Microbiol., 138:1167-1175 (1992)
	M85107， M85108		23S rRNA gene insertion sequence	Roller, C. etc. " there be common the insertion in being characterized as at its 23S rRNA gene of gram positive bacterium with high DNA G+C content ", J.Gen.Microbiol., 138:1167-1175 (1992)
M89931					aecD；brnQ；yhbw	β C-S lyase; Branched-chain amino acid is taken in carrier; The albumen yhbw that supposes	Rossol, I. etc. " a kind of α of Corynebacterium glutamicum aecD genes encoding, the C-S lyase of β-eliminate activity ", J.Bacteriol., 174 (9): 2968-2977 (1992) with degraded aminoethylcysteine; Tauch, A. etc. " Isoleucine among the Corynebacterium glutamicum ATCC 13032 is taken in by the control of brnQ gene product ", Arch.Microbiol., 169 (4): 303-312 (1998)

Table 2 (continuing)
	S59299	trp	Leading gene (promotor)	Herry, D.M. etc. " the trP gene cluster of clone Corynebacterium glutamicum Soviet Union tryptophane superior strain: identify the sudden change of trp leader sequence ", Appl.Environ.Microbiol., 59 (3): 791-799 (1993)
U11545					trpD	Anthranilate phosphoribosyl transferase	O ' Gara, J.P. and Dunican, L.K. (1994) " the complete nucleotide sequences of Corynebacterium glutamicum ATCC 21850 tpD genes ", Thesis, Microbiology Department, University College Galway, Ireland.
	U13922	cgIIM；cgIIR；clgIIR	The II type 5-cytosine(Cyt) methyltransgerase of inferring; The II type restriction endonuclease of inferring; I type of inferring or III type restriction endonuclease	Schafer, A. etc. " from the clone in the DNA district of the encoding stress susceptibility restriction system of Corynebacterium glutamicum ATCC 13032 and characterized and with colibacillary genus between function analysis aspect engaging ", J.Bacterio1., 176 (23): 7309-7319 (1994); " the cgIIM gene of the 5-cytosine(Cyt) in the Corynebacterium glutamicum coding McrBC defective escherichia coli bacterial strain ", Gene, 203 (2): 95-101 (1997)
U14965					recA
	U131224	ppx		Ankri, S. etc. " sudden change in the Corynebacterium glutamicum biosynthetic pathway: the natural bypass of proA step ", J.Bacteriol., 178 (15): 4412-4419 (1996)
U31225					proC	L-proline(Pro): NADP+5-oxydo-reductase	Ankri, S. etc. " sudden change in the Corynebacterium glutamicum biosynthetic pathway: the natural bypass of proA step ", J.Bacteriol., 178 (15): 4412-4419 (1996)
	U31230	obg；proB；unkdh	The gamma-glutamyl kinases; Similar to the specific 2-alcohol acid of D-isomer dehydratase	Ankri, S. etc. " sudden change in the Corynebacterium glutamicum biosynthetic pathway: the natural bypass of proA step ", J.Bacteriol., 178 (15): 4412-4419 (1996)
U31281					bioB	The vitamin H synthase	Serebriiskii, I.G., " two newcomers of bioB superfamily: clone, order-checking and the expression of the bioB gene of Methylobacillus flagellatum and Corynebacterium glutamicum ", Gene, 175:15-22 (1996)

Table 2 (continuing)
	U35023	thtR；accBC	Thiosulfate sulfurtransferase; The acyl-CoA carboxylase	Jager, W. etc. " coding is similar to the Corynebacterium glutamicum gene of two domain proteins of biotin carboxylase and biotin carboxyl carrier protein ", Arch.Microbiol., 166 (2); 76-82 (1996)
U43535					cmr	Multiple drug resistance albumen	Jager, W. etc. " give the Corynebacterium glutamicum gene of multiple drug resistance " in the heterologous host intestinal bacteria, J.Bacteriol., 179 (7): 2449-2451 (1997)
	U43536	clpB	Heat shock ATP is conjugated protein
U53587					aphA-3	3 ' 5 "-aminoglycoside phosphotransferase
	U89648		Participate in the biosynthetic sequence of not identifying of Histidine, partial sequence in the Corynebacterium glutamicum
X04960					TrpA；trpB；trpC；trpD； trpE；trpG；trpL	Tryptophan operon	Matsui, K. etc. " the complete nucleotide sequence and the deduced amino acid of brevibacterium tryptophan operon ", Nucleic Acids Res., 14 (24): 10113-10114 (1986)
	X07563	lysA	The DAP decarboxylase (in-diaminapimelate decarboxylase, EC 4.1.1.20)	Yeh, P. etc. " nucleotide sequence of the lysA gene of Corynebacterium glutamicum with and express to regulate may mechanism ", Mol.Gen.Genet., 212 (1): 112-119 (1988)
X14234					EC?4.1.1.31	Phosphoenolpyruvate carboxylase	Eikmanns, B.J. etc. " the Phosphoenolpyruvate carboxylase gene of Corynebacterium glutamicum: molecular cloning, nucleotide sequence and expression ", Mol.Gen.Genet., 218 (2): 330-339 (1989); Lepiniec, L. etc. " jowar Phosphoenolpyruvate carboxylase gene family: structure, function and molecular evolution ", Plant. Mol.Biol., 21 (3): 487-502 (1993)
	X17313	fda	Fructose-bis phosphate aldolase	Von der Osten, C.H. etc. " molecular cloning, nucleotide sequence and the fine-structure distribution of Corynebacterium glutamicum fda gene: Corynebacterium glutamicum fructose-1; texture ratio of 6-bisphosphate aldolase and I class and II class zymohexase is ", Mol.Microbiol.

Table 2 (continuing)
	X53993	dapA	L-2,3-dihydro 2, dipicolimic acid 2 synthetic enzyme (EC 4.2.1.52)	Bonnassie, S. etc. " nucleotide sequence of Corynebacterium glutamicum dapA gene ", Nucleic Acids Res., 18 (21): 6421 (1990)
X54223						The AttB related locus	Cianciotto, N. etc. " the dna sequence dna homology between the attP site of corynebacterium diphtheriae, ulcer rod bacillus (Corynebacterium ulcerans) and Corynebacterium glutamicum attB related locus and λ Bang Zhuanganjunshijunti ", FEMS, Microbiol, Lett., 66:299-302 (1990)
	X54740	argS；lysA	Arginyl-tRNA synthetase; Diaminapimelate decarboxylase	Marcel, T. etc. " nucleotide sequence in Corynebacterium glutamicum lysA upstream region of gene district and group structure ", Mol. Microbiol., 4 (11): 1819-1830 (1990)
X55994					trpL；trpE	The leading peptide of inferring; O-amino benzoyl acid synthase component I	Heery, D.M. etc. " nucleotide sequence of Corynebacterium glutamicum trpE gene ", Nucleic Acids Res., 18 (23): 7138 (1990)
	X56037	ThrC	Threonine synthase	Han, K.S. etc. " molecular structure of Corynebacterium glutamicum threonine synthase gene ", Mol.Microbiol., 4 (10): 1693-1702 (1990)
X56075					The attB-related locus	Attachment site	Ciancotto, N. etc. " the dna sequence dna homology between the attP site of corynebacterium diphtheriae, ulcer rod bacillus (Corynebacterium ulcerans) and Corynebacterium glutamicum attB related locus and λ Bang Zhuanganjunshijunti ", FEMS.Microbiol.Lett., 66:299-302 (1990)
	X57226	lysC-alpha；lysC-beta； asd	E.C. 2.7.2.4. α subunit; E.C. 2.7.2.4. β subunit; Aspartic acid β semialdehyde desaturase	Kalinowski, J. etc. " heredity of Corynebacterium glutamicum E.C. 2.7.2.4. and biochemical analysis ", Mol. Microbiol, 5 (5): 1197-1204 (1991); Kalinowski, J. etc. " aspartokinase gene lysC α and lysC β are overlapping and adjacent with aspartic acid β semialdehyde deaminase gene asd in Corynebacterium glutamicum ", Mol.Gen.Genet., 224 (3): 317-324 (1990)

Table 2 (continuing)
	X59403	gap；pgk；tpi	Glyceraldehyde-3-phosphate; Phosphoglycerokinase; Triose-phosphate isomerase	Eikmanns, B.J. " Corynebacterium glutamicum gene of a kind of coding three kinds of glycolytic ferment glyceraldehyde-3-phosphate dehydrogenases, glycerol 3-phosphate acid kinase and triose-phosphate isomerases bunch evaluation, sequential analysis and expression ", J.Bacteriol., 174 (19): 6076-6086 (1992)
X59404					gdh	Glutamate dehydrogenase	Bormann, E.R. etc. " analysis of molecules of the Corynebacterium glutamicum gdh gene of coding glutamate dehydrogenase ", Mol.Microbiol., 6 (3): 317-326 (1992)
	X60312	lysI	L-Methionin permease	Seep-Feldhaus, A.H. etc. " participate in the analysis of molecules of the Corynebacterium glutamicum lys1 gene of Methionin absorption ", Mol.Microbiol., 5 (12): 2995-3005 (1991)
X66078					copI	Ps1 albumen	Joliff, G. etc. " clone and nucleotide sequence of the csp1 gene of one of two kinds of main secretory proteins of coding Corynebacterium glutamicum PS1: the N-terminal district of inferring of PS1 is similar to Mycobacterium antigen 85 complex bodys ", Mol.Microbiol., 6 (16): 2349-2362 (1992)
	X66112	glt	Oxalacetic transacetase	Eikmanns, B.J. etc. " cloned sequence, expression and the transcription analysis of the Corynebacterium glutamicum gltA gene of coding Oxalacetic transacetase ", Microbiol., 140:1807-1828 (1994)
X67737					dapB	Dihydro 2, the dipicolimic acid 2 reductase enzyme
	X69103	csp2	S-layer proteins PS2	Peyret, J.L. etc. " characterized of the cspB gene of a kind of orderly S-layer proteins PS2 in the coding Corynebacterium glutamicum ", Mol.Microbiol., 9 (1): 97-109 (1993)
X69104						The IS3 insertion element of being correlated with	Bonamy, C. etc. " evaluation of the relevant insertion sequence IS1206 of a kind of Corynebacterium glutamicum IS3 and kind system analyze ", Mol.Microbiol., 14 (3): 571-581 (1994)
	X70959	leuA	Isopropylmalate synthase	Patek, M. etc. " leucine in the Corynebacterium glutamicum is synthetic: the enzymic activity of leuA, structure and leuA inactivation are to the influence of Methionin synthetic ", Appl.Environ.Microbiol., 60 (1): 133-140 (1994)

Table 2 (continuing)
	X71489	icd	Isocitric enzyme (NADP+)	Eikmanns, B.J. etc. " cloned sequence analysis, expression and the inactivation of the Corynebacterium glutamicum icd gene of coding isocitric enzyme and the biochemical character of this enzyme are identified ", J.Bacteriol., 177 (3): 774-782 (1995)
X72855					GDHA	Glutamate dehydrogenase (NADP+)
	X75083， X70584	mtrA	The 5-methyl tryptophan resistance	Heery, D.M. etc. " sequence of the coding 5-methyl tryptophan resistance of Corynebacterium glutamicum tryptophane superior strain ", Biochem.Biophys.Res.Commun., 201 (3): 1255-1262 (1994)
X75085					recA		Fitzpatrick, R. etc. " structure and the characterized of the recA mutant strain of Corynebacterium glutamicum and brevibacterium ", Appl.Microbiol.Biotechnol., 42 (4): 575-580 (1994)
	X75504	aceA；thiX	The part isocitrate lyase;	Reinscheid, D.J. etc. " characterized of Corynebacterium glutamicum isocitrate lyase gene and the biochemical analysis of this enzyme ", J.Bacteriol., 176 (12): 3474-3483 (1994)
X76875						ATP enzyme β subunit	Ludwig, W. etc. " the bacterium kind system based on EF-T u and the comparative analysis of atp synthase beta subunit gene is related ", Antonie Van Leeuwenhoek, 64:285-305 (1993)
	X77034	tuf	EF-T u	Ludwig, W. etc. " the bacterium kind system based on EF-T u and the comparative analysis of atp synthase beta subunit gene is related ", Antonie Van Leeuwenhoek, 64:285-305 (1993)
X77384					recA		Billman-Jacobe, H. " nucleotide sequence of Corynebacterium glutamicum recA gene ", DNA Seq., 4 (6): 403-404 (1994)
	X78491	accB	Malate synthase	Reinscheid, D.J. etc. " malate synthase of the Corynebacterium glutamicum pta-ack operon of coding phosphoric acid CAT: sequential analysis ", Microbiology, 140:3099-3108 (1994)

Table 2 (continuing)
	X80629	16S?rDNA	The 16S ribosome-RNA(rRNA)	Rainey, F.A. etc. " evidence that the generation of kind system is analyzed and Nocardia bacteria is evolved and originated from from red bacterium radiating of red bacterium genus (Rhodococcus) and Nocardia (Norcardia) ", Microbiol., 141:523-528 (1995)
X81191					gluA；gluB；gluC； gluD	The L-glutamic acid shooting system	Kronemeyer, W. etc. " gluABCD bunch structure of coding Corynebacterium glutamicum L-glutamic acid shooting system ", J.Bacteriol., 177 (5): 1152-1158 (1995)
	X81379	dapE	The succinyl-diaminopimelic acid takes off the succinyl enzyme	Wehrmann, A. etc. " analyses of the different dna fragmentations of the Corynebacterium glutamicum of complementary intestinal bacteria dapE ", Microbiology, 40:3349-56 (1994)
X82061					16S?rDNA	The 16S ribosome-RNA(rRNA)	Ruimy, R. etc. " the kind system by the Corynebacterium of small subunit ribosomal dna sequence analytical derivation takes place ", Int.J.Syst.Bacteriol., 45 (4): 740-746 (1995)
	X82928	asd；lysC	Aspartate-semialdehyde dehydrogenase;	Serebrijski, I. etc. " the osmotic stress dependency complementary action that causes by allos proA in the multiple copied inhibition of asd gene and the proA mutant ", J.Bacteriol., 177 (24): 7255-7260 (1995)
X82929					proA	Gamma-glutamyl phosphoric acid reduction enzyme	Serebrijski, I. etc. " the osmotic stress dependency complementary action that causes by allos proA in the multiple copied inhibition of asd gene and the proA mutant ", J.Bacteriol., 177 (24): 7255-7260 (1995)
	X84257	16S?rDNA	The 16S ribose RNA	Pascual, C. etc. " the kind system based on the Corynebacterium of 16S rRNA gene order analyzes ", Int. J.Syst.Bacteriol., 45 (4): 724-728 (1995)
X85965					aroP；dapE	The aromatic amino acid permease;	Wehrmann etc. " there is the aroP of coding die aromatischen Aminosaeuren translocator in the functional analysis explanation of the flanking sequence of Corynebacterium glutamicum proline(Pro) dapE ", J.Bacteriol., 177 (20): 5991-5993 (1995)

Table 2 (continuing)
	X86157	argB；argC；argD； argF；argJ	Acetylglutamate kinase; N-acetyl-gamma-glutamyl phosphoric acid reduction enzyme; The acetylornithice transaminase; Ornithine carbamyl transferase; Glutamic acid N-acetyltransferase	Sakanyan, V. etc. " arginine biosynthesizing ethanoyl round-robin gene and enzyme in the Corynebacterium glutamicum: the enzyme in the early stage step of arginine pathway is evolved ", Microbiology, 142:99-108 (1996)
X89084					pta；ackA	The phosphoric acid acetyltransferase; E.C. 2.7.2.1	Reinscheid, D.J. etc. " clone, sequential analysis, expression and the inactivation of the Corynebacterium glutamicum pta-ack operon of coding phosphoric acid CAT and E.C. 2.7.2.1 ", Microbiology, 145:503-513 (1999)
	X89850	attB	Attachment site	Le Marrec, C. etc. " hereditary feature of the phi AAU2 site-directed integration function of infection " golden yellow Arthrobacter (Arthrobacter aureus) C70 " is identified ", J.Bacteriol., 178 (7): 1996-2004 (1996)
X90356						Promoter fragment F1	Patek, M. etc. " Corynebacterium glutamicum promotor: the search of clone, analysis of molecules and consensus motif ", Microbiology, 142:1297-1309 (1996)
	X90357		Promoter fragment F2	Patek, M. etc. " Corynebacterium glutamicum promotor: the search of clone, analysis of molecules and consensus motif ", Microbiology, 142:1297-1309 (1996)
X90358						Promoter fragment F10	Patek, M. etc. " Corynebacterium glutamicum promotor: clone, analysis of molecules and consensus motif search element ", Microbiology, 142:1297-1309 (1996)
	X90359		Promoter fragment F13	Patek, M. etc. " Corynebacterium glutamicum promotor: the search of clone, analysis of molecules and consensus motif ", Microbiology, 142:1297-1309 (1996)
X90360						Promoter fragment F22	Patek, M. etc. " Corynebacterium glutamicum promotor: the search of clone, analysis of molecules and consensus motif ", Microbiology, 142:1297-1309 (1996)
	X90361		Promoter fragment F34	Patek, M. etc. " Corynebacterium glutamicum promotor: the search of clone, analysis of molecules and consensus motif ", Microbiology, 142:1297-1309 (1996)

Table 2 (continuing)
	X90362		Promoter fragment F37	Patek, M. etc. " Corynebacterium glutamicum promotor: the search of clone, analysis of molecules and consensus motif ", Microbiology, 142:1297-1309 (1996)
X90363						Promoter fragment F45	Patek, M. etc. " Corynebacterium glutamicum promotor: the search of clone, analysis of molecules and consensus motif ", Microbiology, 142:1297-1309 (1996)
	X90364		Promoter fragment F64	Patek, M. etc. " Corynebacterium glutamicum promotor: the search of clone, analysis of molecules and consensus motif ", Microbiology, 142:1297-1309 (1996)
X90365						Promoter fragment F75	Patek, M. etc. " Corynebacterium glutamicum promotor: the search of clone, analysis of molecules and consensus motif ", Microbiology, 142:1297-1309 (1996)
	X90366		Promoter fragment PF101	Patek, M. etc. " Corynebacterium glutamicum promotor: clone, analysis of molecules and consensus motif search element ", Microbiology, 142:1297-1309 (1996)
X90367						Promoter fragment PF104	Patek, M. etc. " Corynebacterium glutamicum promotor: clone, analysis of molecules and consensus motif search element ", Microbiology, 142:1297-1309 (1996)
	X90368		Promoter fragment PF109	Patek, M. etc. " Corynebacterium glutamicum promotor: clone, the search of analysis of molecules and consensus motif ", Microbiology, 142:1297-1309 (1996)
X93513					amt	The ammonium movement system	Siewe, R.M. etc. " Corynebacterium glutamicum (methyl) ammonium is taken in the function and the hereditary feature of carrier and identified ", J. Biol.Chem., 271 (10): 5398-5403 (1996)
	X93514	betP	The trimethyl-glycine movement system	Pater, H. etc. " Corynebacterium glutamicum betP gene isolation, characterized and the expression of codes match solute trimethyl-glycine movement system ", J.Bacteriol., 178 (17): 5229-5234 (1996)

Table 2 (continuing)
	X95649	orf4		Patek, M. etc. " coding participates in the evaluation and the transcription analysis of the Corynebacterium glutamicum dapB-ORF2-dapA-ORF4 operon of two kinds of enzymes of L-Methionin synthetic ", Biotechnol.Lett., 19:1113-1117 (1997)
X96471					lysE；lysG	Methionin output albumen; Albumen is regulated in Methionin output	Vrljic, M. etc. " the new type carting albumen with novel cell function: the L-Methionin output of Corynebacterium glutamicum ", Mol.Microbiol., 22 (5): 815-826 (1996)
	X96580	panB；panC；xylB	3-methyl-2-hydroxybutyric acid hydroxymethyl transferases; Pantoate-beta-alanine ligase; Xylulokinase	Sahm, H. etc. " the synthetic and excessive production that panBC and coding L-Xie Ansuan synthetic gene is applied to the D-pantoic acid of the D-pantoic acid in the Corynebacterium glutamicum ", Appl.Environ.Microbiol., 65 (5): 1973-1979 (1999)
X96962						Insertion sequence IS1207 and transposase
	X99289		Elongation factor P	Ramos, A. etc. " coded amino acid is produced clone, order-checking and the expression of the gene of elongation factor P in the bacterium brevibacterium (Corynebacterium glutamicum ATCC 13869) ", Gene, 198:217-222 (1997)
Y00140					thrB	Homoserine kinase	Mateos, L.M. etc. " nucleotide sequence of the homoserine kinase of brevibacterium (thrB) gene ", Nucleic Acids Res., 15 (9): 3922 (1987)
	Y00151	ddh	In-diaminopimelic acid D-desaturase (EC 1.4.1.16)	Ishino, S. etc. " Corynebacterium glutamicum in-nucleotide sequence of diaminopimelic acid D-dehydrogenase gene ", Nucleic Acids Res., 15 (9): 3917 (1987)
Y00476					thrA	Homoserine dehydrogenase	Mateos, L.M. etc. " nucleotide sequence of the homoserine dehydrogenase of brevibacterium (thrA) gene ", Nucleic Acids Res., 15 (24): 10598 (1987)
	Y00546	hom；thrB	Homoserine dehydrogenase; Homoserine kinase	Peoples, O.P. etc. " nucleotide sequence and the fine-structure distribution of Corynebacterium glutamicum hom-thrB operon ", Mol.Microbiol., 2 (1): 63-72 (1988)

Table 2 (continuing)
	Y08964	murC；ftsQ/divD；ftsZ	UPD-N-acetylmurami-L-Ala ligase enzyme; Divide initial albumen or cell fission albumen; Cell fission albumen	Honrubia, M.P. etc. " evaluation of brevibacterium ftsZ gene, sign and genome structure ", Mol.Gen.Genet., 259 (1): 97-104 (1998)
Y09163					putP	High affinity proline(Pro) movement system	Peter, H. etc. " characterized of the low affinity shooting system of the separation of Corynebacterium glutamicum putP gene and coupling solute ", Arch.Microbiol., 168 (2): 143-151 (1997)
	Y09548	pyc	Pyruvate carboxylase	Peters-Wendisch, P.G. etc. " Corynebacterium glutamicum pyruvate carboxylase: the characterized of pyc gene, expression and inactivation ", Microbiology, 144:915-927 (1998)
Y09578					leuB	3-Isopropylmalate dehydrogenase	Patek, M. etc. " analysis of Corynebacterium glutamicum leuB gene ", Appl.Microbiol.Biotechnol., 50 (1): 42-47 (1998)
	Y12472		Attachment site phage Phi-16	Moreau, S. etc. " site-directed integration of excellent bacillus phage Phi-16: the structure of integrative vector ", Microbiol., 145:539-548 (1999)
Y12537					proP	Proline(Pro)/ectoine shooting system albumen	Peter, H. etc. " Corynebacterium glutamicum has second carrier of four kinds of coupling solutes: evaluation, order-checking and the characterized of proline(Pro)/ectoine shooting system ProP and ectoine/ proline(Pro)/trimethyl-glycine carrier EctP ", J.Bacteriol., 180 (22): 6005-6012 (1998)
	Y13221	glnA	Glutamine synthetase I	Jakoby, M. etc. " separation of the Corynebacterium glutamicum glnA gene of coding NADPH-linked glutamate synthase I ", FEMS Microbiol.Lett., 154 (1): 81-88 (1997)
Y16642					lpd	Dihydrolipoamide dehydrogenase
	Y18059		Attachment site rod bacillus phage 304L	Moreau, “ ﹠phi such as S.; The analysis of 304L integration function: a kind of intergrase assembly in the excellent bacillus phage ", Virology, 255 (1): 150-159 (1999)

Table 2 (continuing)
	Z21501	ArgS; LysA	Arginyl-tRNA synthetase; Diaminapimelate decarboxylase (part)	Oguiza, J.A. etc. " gene of coding Arginyl-tRNA synthetase is positioned at the upstream of brevibacterium lysA gene: arginine is to the adjusting of argS-lysA bunch of expression ", J.Bacteriol., 175 (22): 7356-7362 (1993)
Z21502					DapA; Dapb	Dihydro 2, the dipicolimic acid 2 synthase; Dihydro 2, the dipicolimic acid 2 reductase enzyme	Pisabarro, A. etc. " the gene cluster coding dihydro 2 of three genes of brevibacterium (dapA, orf2 and dapB); the third polypeptide of dipicolimic acid 2 reductase enzyme and a kind of Unknown Function ", J.Bacteriol., 175 (9): 2743-2749 (1993)
	Z29563	ThrC	Threonine synthase	Malumbres, M. etc. " analysis and the expression of the thrC gene of coding threonine synthase ", Appl. Environ.Microbiol., 60 (7) 2209-2219 (1994)
Z46753					16S rDNA	The gene of 16S ribosome-RNA(rRNA)
	Z49822	SigA	The SigA Sigma Factors	Oguiza, J.A. etc. " a plurality of Sigma Factors genes in the brevibacterium: the characterized of sigA and sigB ", J.Bacteriol., 178 (2): 550-553 (1996)
Z49823					GalE; DtxR	Catalytic activity UDP-semi-lactosi 4-epimerase; Diphtheria toxin is regulated albumen	Oguiza, J.A. etc. " the galE gene and the dmdR genetic transcription coupling of Corynebacterium glutamicum coding UDP-semi-lactosi 4-epimerase ", Gene, 177:103-107 (1996)
	Z49824	OrfI; SigB	"; The SigB Sigma Factors	Oguiza, J.A. etc. " a plurality of Sigma Factors genes in the brevibacterium: the characterized of sigA and sigB ", Gene, 178 (2): 550-553 (1996)
Z66534						Transposase	Correia, A. etc. " clone and the characterized that are present in the IS sample element among the brevibacterium ATCC 13869 ", Gene, 170 (1): 91-94 (1996)
	1The sequence of this gene is published in the specified reference.Yet the sequence that the present inventor obtains obviously is longer than the form of being announced.Think that the form of being announced depends on incorrect initiator codon, therefore only represent the fragment of true coding region.

Table 3: can be used to implement Corynebacterium of the present invention and brevibacterium sp bacterial strain

Bacterial classification	ATCC	FRRM	NRRL	CECT	NCIMB	CBS	NCTC	DSMZ
									Brevibacterium ammoniagenes (Brevibacterium ammoniagenes)	21054
Brevibacterium ammoniagenes	19350
									Brevibacterium ammoniagenes	19351
Brevibacterium ammoniagenes	19352
									Brevibacterium ammoniagenes	19353
Brevibacterium ammoniagenes	19354
									Brevibacterium ammoniagenes	19355
Brevibacterium ammoniagenes	19356
									Brevibacterium ammoniagenes	21055
Brevibacterium ammoniagenes	21077
									Brevibacterium ammoniagenes	21553
Brevibacterium ammoniagenes	21580
									Brevibacterium ammoniagenes	39101
Brevibacterium ammoniagenes (Brevibacterium butanicum)	21196
									Brevibacterium ammoniagenes (Brevibacterium divaricatum)	21792	P928
Deep yellow tyrothricin (Brevibacterium flavum)	21474
									Deep yellow tyrothricin	21129
Deep yellow tyrothricin	21518
									Deep yellow tyrothricin			B11474
Deep yellow tyrothricin			B11472
									Deep yellow tyrothricin	21127
Deep yellow tyrothricin	21128
									Deep yellow tyrothricin	21427
Deep yellow tyrothricin	21475
									Deep yellow tyrothricin	21517
Deep yellow tyrothricin	21528
									Deep yellow tyrothricin	21529
Deep yellow tyrothricin			B11477
									Deep yellow tyrothricin			B11478
Deep yellow tyrothricin	21127
									Deep yellow tyrothricin			B11474
Xi Shi tyrothricin (Brevibacterium healii)	15527
									Ketoisocaproic tyrothricin (Brevibacterium ketoglutamicum)	21004
The ketoisocaproic tyrothricin	21089
									The ketoisocaproic tyrothricin	21914
Brevibacterium				70
									Brevibacterium				74
Brevibacterium				77
									Brevibacterium	21798
Brevibacterium	21799
									Brevibacterium	21800
Brevibacterium	21801
									Brevibacterium			B11470
Brevibacterium			B11471

Bacterial classification	ATCC	FRRM	NRRL	CECT	NCIMB	CBS	NCTC	DSMZ
									Brevibacterium	21086
Brevibacterium	21420
									Brevibacterium	21086
Brevibacterium	31269
									Extension brevibacterium (Brevibacterium linens)	9174
Extension brevibacterium	19391
									Extension brevibacterium	8377
Brevibacterium paraffinolvticum					11160
									Tyrothricin (Brevibacterium spec.)						717.73
Tyrothricin						717.73
									Tyrothricin	14604
Tyrothricin	21860
									Tyrothricin	21864
Tyrothricin	21865
									Tyrothricin	21866
Tyrothricin	19240
									Corynebacterium acctoacidophlum (Corynebacterium acetoacidophilum)	21476
Corynebacterium acctoacidophlum	13870
									Have a liking for vinegar paddy rod bacillus			B11473
Have a liking for vinegar paddy rod bacillus			B11475
									Have a liking for vinegar paddy rod bacillus	15806
Have a liking for vinegar paddy rod bacillus	21491
									Have a liking for vinegar paddy rod bacillus	31270
Have a liking for acetyl rod bacillus (Corynebacterium acetophilum)			B3671
									Brevibacterium ammoniagenes	6872						2399
Brevibacterium ammoniagenes	15511
									Corynebacterium?fujiokense	21496
Corynebacterium glutamicum	14067
									Corynebacterium glutamicum	39137
Corynebacterium glutamicum	21254
									Corynebacterium glutamicum	21255
Corynebacterium glutamicum	31830
									Corynebacterium glutamicum	13032
Corynebacterium glutamicum	14305
									Corynebacterium glutamicum	15455
Corynebacterium glutamicum	13058
									Corynebacterium glutamicum	13059
Corynebacterium glutamicum	13060
									Corynebacterium glutamicum	21492
Corynebacterium glutamicum	21513
									Corynebacterium glutamicum	21526
Corynebacterium glutamicum	21543
									Corynebacterium glutamicum	13287
Corynebacterium glutamicum	21851
									Corynebacterium glutamicum	21253
Corynebacterium glutamicum	21514
									Corynebacterium glutamicum	21516

Bacterial classification	ATCC	FRRM	NRRL	CECT	NCIMB	CBS	NCTC	DSMZ
									Corynebacterium glutamicum	21299
Corynebacterium glutamicum	21300
									Corynebacterium glutamicum	39684
Corynebacterium glutamicum	21488
									Corynebacterium glutamicum	21649
Corynebacterium glutamicum	21650
									Corynebacterium glutamicum	19223
Corynebacterium glutamicum	13869
									Corynebacterium glutamicum	21157
Corynebacterium glutamicum	21158
									Corynebacterium glutamicum	21159
Corynebacterium glutamicum	21355
									Corynebacterium glutamicum	31808
Corynebacterium glutamicum	21674
									Corynebacterium glutamicum	21562
Corynebacterium glutamicum	21563
									Corynebacterium glutamicum	21564
Corynebacterium glutamicum	21565
									Corynebacterium glutamicum	21566
Corynebacterium glutamicum	21567
									Corynebacterium glutamicum	21568
Corynebacterium glutamicum	21569
									Corynebacterium glutamicum	21570
Corynebacterium glutamicum	21571
									Corynebacterium glutamicum	21572
Corynebacterium glutamicum	21573
									Corynebacterium glutamicum	21579
Corynebacterium glutamicum	19049
									Corynebacterium glutamicum	19050
Corynebacterium glutamicum	19051
									Corynebacterium glutamicum	19052
Corynebacterium glutamicum	19053
									Corynebacterium glutamicum	19054
Corynebacterium glutamicum	19055
									Corynebacterium glutamicum	19056
Corynebacterium glutamicum	19057
									Corynebacterium glutamicum	19058
Corynebacterium glutamicum	19059
									Corynebacterium glutamicum	19060
Corynebacterium glutamicum	19185
									Corynebacterium glutamicum	13286
Corynebacterium glutamicum	21515
									Corynebacterium glutamicum	21527
Corynebacterium glutamicum	21544
									Corynebacterium glutamicum	21492
Corynebacterium glutamicum			B8183
									Corynebacterium glutamicum			B8182
Corynebacterium glutamicum			B12416
									Corynebacterium glutamicum			B12417
Corynebacterium glutamicum			B12418
									Corynebacterium glutamicum			B11476
Corynebacterium glutamicum	21608

Bacterial classification	ATCC	FRRM	NRRL	CECT	NCIMB	CBS	NCTC	DSMZ
									Lily hedysarum scoparium bacillus (Corynebacterium lilium)		P973
Corynebacterium?nitrilophilus	21419				11594
									Rod bacillus (Corynebacterium spec.)		P4445
The rod bacillus		P4446
									The rod bacillus	31088
The rod bacillus	31089
									The rod bacillus	31090
The rod bacillus	31090
									The rod bacillus	31090
The rod bacillus	15954							20145
									The rod bacillus	21857
The rod bacillus	21862
									The rod bacillus	21863

ATCC: American type culture collection (American Type Culture Collection, Rockville, MD, USA).

FERM: Japanese fermentation research institute (Fermentation Research Institute, Chiba, Japan).

NRRL: american agriculture research institution preservation center (ARS Culture Collection, Northern Regional ResearchLaboratory, Peoria, USA).

CECT: Spain typical case's culture collection center (Coleccion Espanola de Cultivos Tipo, Valencia, Spain).

NCIMB: state-run industry of Britain and marine microorganism preservation company limited (National Collection of Industrial andMarine Bacteria Ltd., Aberdeen, UK).

CBS: Dutch fungi strain preservation center (Centraalbureau voor Schimmelcultures, Baarn, NL).

NCTC: Britain state-run typical culture collection center (National Collection of Type Cultures, London, UK).

DSMZ: Germany microbial preservation center (Deutsche Sammlung von Mikroorganismen und Zellkulturen, Braunschweig, Germany).

Reference is seen: Sugawara, H. etc. (1993) World directory of collections of cultures of microorganisms:Bacteria, fungi and yeasts (4 ^ThEdn), World federation for culture collections world data center onmicroorganisms, Saimata, Japan.

Table 4: sequence alignment result

ID#	Length N T	Genank hits	Length	Registration number	The title that Genbank hits	The source that Genbank hits	Homology % (GAP)	Date of entry
									Rxa00013 rxa00014 rxa00030 rxa00032 rxa00041 rxa00042	996 903 513 1,632 1,342 882	GB_GSS4：AQ713475 GB_HTG3：AC007420 GB_HTG3：AC007420 GB_BA1：MTCY3A2 GB_BA1：MLCB1779 GB_BA1：SAPURCLU S GB_EST21：C89713 GB_EST28：AI497294 GB_EST21：C92167 GB_BA2：AF010496 GB_BA2：AF018073 GB_BA2：AF045245 EM_PAT：E11760 GB_PAT：126124 GB_IN1：LMFL5883 EM_PAT：E11760 GB_PAT：I26124	581 130,583 130,583 25,830 43,254 9,120 767 484 637 189,370 9,810 5,930 6,911 6,911 31,934 6,911 6911	AQ713475 AC007420 AC007420 Z83867 Z98271 X92429 C89713 AI497294 C92167 AF010496 AF018073 AF045245 E11760 126124 AL117384 E11760 I26124	HS_5402_B2_A12_T7A RPCI-11 male sex BAC library people's gene group clone flat board=978 row=24 row=B, genome summary sequence.Drosophila melanogaster chromosome 2 clone BACR07M10 (D630) RPCI-98 07.M.10map 24A-24D bacterial strain y; Cn bw sp, * *Check order * *, 83 non-sequential segments.Drosophila melanogaster chromosome 2 clone BACR07M10 (D630) RPCI-98 07.M.10map 24A-24D bacterial strain y; Cn bw sp, * *Check order * *, 83 non-sequential segments.Mycobacterium tuberculosis H37Rv complete genome group; Black in vain streptomycete (S.alboniger) napH of sections 136/162 Mycobacterium leprae clay B1779, pur7, pur10, pur6, pur4, pur5 and pur3 gene C 89713 Dictyostelium discoideum SS (H.Urushihara) Dictyostelium discoideum cDNA clone SSG229, mRNA sequence fb63g03.y1 Zebrafish WashU MPING EST Danio rerio cDNA 5 ' is similar to SW:AFP4_MYOOC P80961 antifreeze protein LS-12; MRNA sequence C 92167 Dictyostelium discoideum SS (H.Urushihara) Dictyostelium discoideum cDNA clone SSD179, mRNA sequence pod membrane Rhodobacter strain SB1003, the red bacterium operon of portion gene category ball is regulated albumen (smoC), pericentral siphon sorbyl alcohol conjugated protein (smoE), sorbyl alcohol/N.F,USP MANNITOL transhipment inner membrane protein (smoF), sorbyl alcohol/N.F,USP MANNITOL transhipment inner membrane protein (smoG), sorbyl alcohol/N.F,USP MANNITOL transhipment ATP binding transport albumen (smoK), sorbito dehy drogenase (smoS), mannitol dehydrogenase (mtlK) and pericentral siphon N.F,USP MANNITOL conjugated protein (smoM) gene, complete cds.Klebsiella pneumonia D-arabitol translocator (dalT), D-arabitol kinases (dalK), D-pectinose alcoholdehydrogenase (dalD) and repressor (dalR) gene, complete cds.The sequence 4 Leishmania major Friedlin karyomit(e)s 23 clay L5883 of saccharase gene base sequence United States Patent (USP) 5556776, the sequence 4 of complete sequence saccharase gene base sequence United States Patent (USP) 5556776	The unknown Leishmania major of people (Homo sapiens) Drosophila melanogaster (Drosophila melanogaster) Drosophila melanogaster Much's bacillus Mycobacterium leprae (Mycobacterium leprae) ring streptomycete (Streptomyces anulatus) the Dictyostelium discoideum Danio rerio Dictyostelium discoideum pod membrane red bacterium of red bacterium (Rhodobacter capsulatus) class ball (Rhodobacter sphaeroides) Friedlanders bacillus (Klebsiella pneumoniae) Corynebacterium glutamicum Corynebacterium glutamicum is unknown	37,148 34,568 34,568 58,140 57,589 55,667 45,283 42,991 44,444 39,689 48,045 38,514 99,031 99,031 43,663 94,767 94,767	99-07-13 99-09-20 99-09-20 98-06-17 97-08-08 96-02-28 98-04-20 99-03-11 99-07-12 98-05-12 97-10-22 98-07-16 97-10-08 (Rel.52, Created) 96-10-07 99-10-21 97-10-08 (Rel.52, Created) 96-10-07

Table 4 (continuing)

Rxa00043 rxa00098 rxa00148 rxa00149 rxa00195 rxa00196 rxa00202 rxa00206

1,287 1,743 2,334 1,971 684 738 1,065 1161

GB_IN1：CEU33051 GB_PAT：I26124 EM_PAT：E11760 GB_PR3：AC005174 GB_BA1：MSU88433 GB_BA1：SC5A7 GB_BA1：MTCY10D7 GB_BA1：MTCY277 GB_BA1：MSGY456 GB_BA1：MSGY175 GB_BA1：MSGY456 GB_BA1：MSGY175 GB_BA1：MTCY277 GB_BA1：MTCY274 GB BA1：MSGB1529C S GB_BA1：MTCY274 GB_BA1：MTCY274 GB_BA1：MTCY274 GB_RO：RATCBRQ GB_EST11：AA253618 GB_EST26：AI390284 GB_EST26：AI390280 GB_BA1：MLCB637 GB_BA1：MTV012

4,899 6,911 6,911 39,769 1,928 40,337 39,800 38,300 37,316 18,106 37,316 18,106 38,300 39,991 36,985 39,991 39,991 39,991 10,752 313 490 467 44,882 70287

U33051 I26124 E11760 AC005174 U88433 AL031107 Z79700 Z79701 AD000001 AD000015 AD000001 AD000015 Z79701 Z74024 L78824 Z74024 Z74024 Z74024 M55532 AA253618 AI390284 AI390280 Z99263 AL021287

Caenorhabditis elegans sur-2mRNA, complete cds.The sequence 4 of United States Patent (USP) 5556776.The saccharase gene base sequence.The people clones UWGC:g1564a012,7p14-15, complete sequence.Smegma mycobacterium phosphoglucose isomerase gene, complete cds.Streptomyces coelicolor clay 5A7.Mycobacterium tuberculosis H37Rv complete genome group; Sections 44/162.Mycobacterium tuberculosis H37Rv complete genome group; Sections 65/162.The mycobacterium tuberculosis sequence of clone y456.The mycobacterium tuberculosis sequence of clone y175.The mycobacterium tuberculosis sequence of clone y456.The mycobacterium tuberculosis sequence of clone y175.Mycobacterium tuberculosis H37Rv complete genome group; Sections 65/162.Mycobacterium tuberculosis H37Rv complete genome group; Sections 126/162.Mycobacterium leprae clay B1529DNA sequence.Mycobacterium tuberculosis H37Rv complete genome group; Sections 126/162.Mycobacterium tuberculosis H37Rv complete genome group; Sections 126/162.Mycobacterium tuberculosis H37Rv complete genome group; Sections 126/162.Rat carbohydrate bind receptor gene, complete cds.Mw95c 10.r1 Soares mouse NML house mouse cDNA clones IMAGE:678450 5 ', mRNA sequence.Mw96a03.71 Soares mouse NML house mouse cDNA clones IMAGE:678508 5 ', is similar to the TR:O09171 betaine homocysteine methyl transferase; The mRNA sequence.Mw95c 10.y1 Soares mouse NML house mouse cDNA clones IMAGE:678450 5 ', mRNA sequence.Mycobacterium leprae clay B637.Mycobacterium tuberculosis H37Rv complete genome group; Sections 132/162.

Unknown Corynebacterium glutamicum people smegma mycobacterium (Mycobacterium smegmatis) streptomyces coelicolor (Streptomyces coelicolor) Much's bacillus Much's bacillus Much's bacillus Much's bacillus Much's bacillus Much's bacillus Much's bacillus Much's bacillus Mycobacterium leprae Much's bacillus Much's bacillus Much's bacillus brown rat (Rattus norvegicus) house mouse (Mus musculus) the house mouse house mouse of Caenorhabditis elegans Mycobacterium leprae Much's bacillus

40,276 97,591 97,591 35,879 62,658 37,638 36,784 67,457 40,883 67,457 35,883 51,001 51,001 35,735 57,014 41,892 41,841 36,599 36,212 38,816 42,239 37,307 58,312 36,632

96-01-23 96-10-07 97-10-08 (Rel.52, Created) 98-06-24 97-04-19 98-07-27 98-06-17 98-06-17 96-12-03 96-12-10 96-12-03 96-12-10 98-06-17 98-06-19 96-06-15 98-06-19 98-06-19 98-06-19 93-04-27 97-03-13 99-02-02 99-02-02 97-09-17 99-06-23

Table 4 (continuing)

Rxa00224 rxa00225 rxa00235 rxa00246 rxa00251 rxa00288 rxa00293

1,074 909 1,398 1,158 831 1,134 1035

GB_BA1：SC6E10 GB_BA1：BJU32230 GB_BA1：PDEETFAB GB_HTG3：AC009689 GB_RO：AF060178 GB_GSS11：AQ325043 GB_EST31：AI676413 GB_BA1：MTCY10G2 GB_BA2：AF061753 GB_BA2：AF086791 GB_BA2：AF012550 GB_PAT：E03856 GB_BA1：BACADHT GB_BA1：MTCY20G9 GB_BA1：MTV004 GB_BA1：MTV004 GB_BA2：AF050114 GB_GSS3：B16984 GB_IN2：AF144549 GB_EST1：T28483

23,990 1,769 2,440 177,954 2,057 734 551 38,970 3,721 37,867 2,690 1,506 1,688 37,218 69,350 69,350 1,038 469 7,887 313

AL109661 U32230 L14864 AC009689 AF060178 AQ325043 AI676413 Z92539 AF061753 AF086791 AF012550 E03856 D90421 Z77162 AL009198 AL009198 AF050114 B16984 AF144549 T28483

Streptomyces coelicolor clay 6E10.Soybean little subunit of living slowly root nodule bacterium electron transfer flavoprotein (etfS) and large subunit (etfL) gene, complete cds.Paracoccus denitrificans electron transfer flavoprotein α and β subunit gene, complete cds.Human chromosome 4 clone 104_F_7map4, the low sequence of samples of passing through.House mouse Suleparoid 2-sulfotransferase (Hs2st) mRNA, complete cds.Mgxb0020J01r CUGI Rice Blast BAC library Magnaporthe grisea genomic clone mgxb0020J01r, genome summary sequence.EtmEST0167 EtH1 eimeria avium (Eimeria tenella) cDNA clones etmc074 5 ', mRNA sequence.Mycobacterium tuberculosis H37Rv complete genome group; Sections 47/162.Nitrosomonas europaea CTP synthase (pyrG) gene, part cds; And Hydratase, phosphoenolpyruvate (eno) gene, complete cds.Zymononas mobilis bacterial strain ZM4 clones the little subunit of 67E10 carbamylphosphate synthetase (carA).Carbamylphosphate synthetase large subunit (carB), transcriptional elongation factor (greA), Hydratase, phosphoenolpyruvate (eno).Pyruvic oxidase alpha subunit (pdhA), pyruvic oxidase β subunit (pdhB), ribonuclease H (mh), homoserine kinase homologue, ethanol dehydrogenase II (adhB) and exonuclease ABC subunit A (uvrA) gene, complete cds; And unknown gene.Acinetobacter calcoaceticus BD413 ComP (comP) gene, complete cds.The gDNA of coding ethanol dehydrogenase.The adhT gene of bacstearothermophilus ethanol dehydrogenase.Mycobacterium tuberculosis H37Rv complete genome group; Sections 25/162.Mycobacterium tuberculosis H37Rv complete genome group; Sections 144/162.Mycobacterium tuberculosis H37Rv complete genome group; Sections 144/162.Pseudomonas W7 alginic acid lyase, complete cds.344A14.TVC CIT978SKA1 people's gene group clone A-344A14, genome summary sequence.Aedes albopictus (Aedes albopictus) ribosomal protein L 34 (rP134) gene, complete cds.EST46182 people's kidney people cDNA3 ' does not hold, and is similar to the monooxygenase 1 (HT:1956) that contains flavoprotein, the mRNA sequence.

Streptomyces coelicolor A3 (2) soybean is living rhizobium (Bradyrhizobium japonicum) Paracoccus denitrificans (paracoccus denitrificans) people house mouse Magnaporthe grisea eimeria avium Much's bacillus Nitrosomonas europaeas (Nitrosomonas europaea) Zymononas mobilis acinetobacter calcoaceticus BD413 (Acinetobacter sp. BD413) bacillus stearothermophiluses (Bacillus stearothermophilus) bacillus stearothermophilus Much's bacillus Much's bacillus Much's bacillus pseudomonas bacterium (Pseudomonas sp.) W7 people's aedes albopictus people slowly

38,616 48,038 48,351 38,756 39,506 38,333 35,542 65,759 58,941 61,239 53,726 51,688 51,602 42,875 40,380 41,789 49,898 39,355 36,509 42,997

99-08-05 96-05-25 93-10-27 99-08-28 98-06-18 99-01-08 99-05-19 98-06-17 98-08-31 98-11-04 99-09-27 97-09-29 99-02-07 98-06-17 98-06-18 98-06-18 99-03-03 98-06-04 99-06-03 95-09-06

Table 4 (continuing)

Rxa00296 rxa00310 rxa00317 rxa00327 rxa00328 rxa00329 rxa00340 rxa00379

2,967 558 777 507 615 1,347 1,269 307

GB_PR1：HUMFMOI GB_EST32：AI734238 GB_HTG6：AC011069 GB_EST15：AA531468 GB_HTG6：AC011069 GB_VI：VMVY16780 GB_VI：VARCG GB_VI：VVCGAA GB_HTG3：AC009571 GB_HT3：AC009571 GB_PR3：AC005697 GB_BA1：LCATPASEB GB_BA1：LCATPASEB GB_BA1：STYPUTPE GB_BA1：STYPUTPF GB_BA1：STYPUTPI GB_PR3：AC004691 GB_PR4：AC004916 GB_PR3：AC004691 GB_BA1：MTCY427 GB_GSS12：AQ412290 GB_PL2：AF112871 GB_HTG1：CEY56A3 GB_HTG1：CEY56A3

2,134 512 168,266 414 168,266 186,986 186,103 185,578 159,648 159,648 174,503 1,514 1,514 1,887 1,887 1,889 141,990 129,014 141,990 38,110 238 2,394 224,746 224746

M64082 AI734238 AC011069 AA531468 AC011069 Y16780 L22579 X69198 AC009571 AC009571 AC005697 X64542 X64542 L0113X L01139 L01142 AC004691 AC004916 AC004691 Z70692 AQ412290 AF112871 AL022280 AL022280

The people contains monooxygenase (FMOI) mRNA of flavoprotein, complete cds.Zb73c05.y5 Soares_ fetus _ lung _ NbIIL 19W people cDNA clones IMAGE:309224 5 ', is similar to gb:M64082 dimethyl propylene propylhomoserin monooxygenase (people); The mRNA sequence.Drosophila melanogaster chromosome X clone BACR11H20 (D881) RPCI-98 11.H.20map 12B-12C bacterial strain y; Cn bw sp, * *Check order * *, 92 non-sequential segments.Nj63d12.s1 NCI_CGAP_Pr10 people cDNA clones IMAGE:997175, mRNA sequence.Drosophila melanogaster chromosome X clone BACR11H20 (D881) RPCI-98 11.H20map 12B-12C bacterial strain y; Cn bw sp, * *Check order * *, 92 non-sequential segments.Milk-pox virus (Variola minor virus) complete genome group.Variola major virus (Variola major virus) (bacterial strain Bangladesh-1975) complete genome group.Variola virus (Variola virus) DNA complete genome group.Human chromosome 4 clone 57_A_22map 4, * *Check order * *, 8 non-sequential segments.Human chromosome 4 clone 57_A_22map 4, * *Check order * *, 8 non-sequential segments.Human chromosome 17, clone hRPK.138_P_22, complete sequence.Lactobacterium casei ATP enzyme β subunit gene.Lactobacterium casei ATP enzyme β subunit gene.Salmonellas (S2980) proline(Pro) permease (putP) gene, 5 ' end.Salmonellas (S2983) proline(Pro) permease (putP) gene, 5 ' end.Salmonellas (S3015) proline(Pro) permease (putP) gene, 5 ' end.The pac clone DJ0740D02 of people 7p14-p15, complete sequence.The people clones DJ0891L14, complete sequence.The pac clone DJ0740D02 of people 7p14-p15, complete sequence.Mycobacterium tuberculosis H37Rv complete genome group; Sections 99/162.RPCI-11-195H2.TV RPCI-11 people's gene group clone RPCI-11-195H2, genome summary sequence.The little subunit of Astasia longa ribosomal RNA gene, complete sequence.Caenorhabditis elegans karyomit(e) III clones Y56A3, * *Check order * *, non-sequential segments.Caenorhabditis elegans karyomit(e) III clones Y56A3, * *Check order * *, non-sequential segments.

Everybody bacillus tuberculosis typus humanus people Astasia longa Caenorhabditis elegans Caenorhabditis elegans of everybody lactobacterium casei (Lactobacillus casei) lactobacterium casei salmonella bacterium (Salmonella sp.) salmonella bacterium salmonella bacterium of everybody drosophila melanogaster people drosophila melanogaster milk-pox virus variola major virus variola virus people

37,915 41,502 33,890 40,821 30,963 35,883 34,664 36,000 36,988 36,988 36,340 34,664 39,308 39,623 39,623 42,906 38,142 38,549 35,865 38,940 36,555 36,465 35,179 35,179

94-11-08 99-06-14 99-12-02 97-08-20 99-12-02 99-09-02 95-01-12 96-12-13 99-09-29 99-09-29 98-10-09 92-12-11 92-12-11 96-05-09 96-05-09 96-05-09 98-05-16 99-07-17 98-05-16 99-06-24 99-03-23 99-06-28 99-09-06 99-09-06

Table 4 (continuing)

Rxa00381 rxa00385 rxa00388 rxa00427 rxa00483 rxa00511 rxa00512

729 362 1,134 909 1,587 615 718

GB_PR2：HS134019 GB_GSS4：AQ730532 GB_EST23：AI120939 GB_EST23：AI120939 GB_EST32：AI726450 GB_GSS4：AQ740856 GB_PR1：HSPAIP GB_BA1：MTY25D10 GB_BA1：MSGY224 GB_HTG1：AP0000471 GB_BA1：MSGY126 GB_BA1：MTY13D12 GB_HTG1：CEY48C3 GB_PR2：HSAF001550 GB_BA1：LLCPJW565 GB_HTG2：AC006754 GB_PR3：HSE127C11 GB_PR3：HSE127C11 GB_BA1：MTCY22G8

86,897 416 561 561 565 768 1,587 40,838 40,051 72,466 37,164 37,085 270,193 173,882 12,828 206,217 38,423 38,423 22550

AL034555 AQ730532 AI120939 AI120939 AI726450 AQ740856 X91809 Z95558 AD000004 AP000471 AD000012 Z80343 Z92855 AF001550 Y12736 AC006754 Z74581 Z74581 Z95585

The human DNA sequence of the clone 134O19 of karyomit(e) lp36.11-3633.Complete sequence.People's gene group sperm library D people's gene group clone flat board=2149 of HS_2149_A1_C06_T7C CIT approval, row=11, OK=and E, genome summary sequence.Ub74f05.r1 Soares mouse mammary gland NMLMG house mouse cDNA clones IMAGE:1383489 5 ', is similar to gb:J04046 calmodulin (people); Gb:M19381 mouse calmodulin (mouse); The mRNA sequence.Ub74105.r1 Soares mouse mammary gland NMLMG house mouse cDNA clones IMAGE:1383489 5 ', is similar to gb:J04046 calmodulin (people); Gb:M19381 mouse calmodulin (mouse); The nRNA sequence.Six days cotton fiber upland cotton of BNLGHi5857 cDNA 5 ' is similar to (AF015913) Skb1Hs[people], the mRNA sequence.People's gene group sperm library D people's gene group clone flat board=2274 of HS_2274_A2_A07_T7C CIT approval, row=14, OK=and A, genome summary sequence.The proteic mRNA of people GAIP.Mycobacterium tuberculosis H37Rv complete genome group; Sections 28/162.The sequence of mycobacterium tuberculosis clone y224.Human chromosome 21 clone B2308H15map 21q22.3, * *Check order * *, non-sequential segments.The sequence of mycobacterium tuberculosis clone y126.Mycobacterium tuberculosis H37Rv complete genome group; Sections 156/162.Caenorhabditis elegans karyomit(e) II clones Y48C3, * *Check order * *, non-sequential segments.Human chromosome 16BAC clone CIT987SK-334D11 complete sequence.Lactococcus lactis subsp plasmid pJW565DNA, abiiM.abiiR gene and orfX Caenorhabditis elegans clone Y40B10, * *Check order * *, 5 non-sequential segments.The human DNA sequence of the clay E127C11 that chromosome 22 q11.2-q does not hold is contained STS.The human DNA sequence of the clay E127C11 that chromosome 22 q11.2-q does not hold is contained STS.Mycobacterium tuberculosis H37Rv complete genome group; Sections 49/162.

Everybody is house mouse house mouse upland cotton (Gossypium hirsutum) people bacillus tuberculosis typus humanus mycobacterium tuberculosis bacillus tuberculosis typus humanus's mycobacterium tuberculosis Caenorhabditis elegans people's lactococcus lactis subsp (Lactococcus lactis subsp.cremoris) Caenorhabditis elegans people bacillus tuberculosis typus humanus

40,604 35,766 41,113 41,113 41,152 41,360 36,792 51,852 51,852 36,875 60,022 60,022 28,013 38,226 37,492 36,648 39,831 36,409 56,232

99-11-23 99-07-15 98-09-02 98-09-02 99-06-11 99-07-16 96-03-29 98-06-17 96-12-03 99-09-13 96-12-10 98-06-17 99-05-29 97-08-22 99-03-01 99-02-23 99-11-23 99-11-23 98-06-17

Table 4 (continuing)

Rxa00517 rxa00518 rxa00606 rxa00635 rxa00679 rxa00680 rxa00682

1,164 320 2,378 1,860 1,389 441 2022

GB_BA1：MSGLTA GB_BA2：ECU73857 GB_HTG2：AC006911 GB_HTG2：AC006911 GB_EST29：AI602158 GB_BA2：ECU73857 GB_BA2：STU51879 GB_BA2：AE000140 GB_EST32：AU068253 GB_EST13：AA363046 GB_EST32：AU068253 GB_BA1：PAORF1 GB_BA1：PAORF1 GB_PL2：AC010871 GB_PL1：AT81KBGEN GB_PL2：AC010871 GB_PR3：AC004058 GB_PL1：AT81KBGEN GB_PL1：AB026648 GB_HTG3：AC010325 GB_HTG3：AC010325 GB_PR4：AC008179

1,776 128,824 298,804 298,804 481 128,824 8,371 12,498 376 329 376 1,440 1,440 80,381 81,493 80,381 38,400 81,493 43,481 197,110 197,110 181745

X60513 U73857 AC006911 AC006911 AI602158 U73857 U51879 AE000140 AU068253 AA363046 AU068253 X13378 X13378 AC010871 X98130 AC010871 AC004058 X98130 AB026648 AC010325 AC010325 AC008179

Smegma mycobacterium Oxalacetic transacetase gltA gene.Intestinal bacteria minute chromosome 6-8.Caenorhabditis elegans clones Y94H6x, * *Check order * *, 15 non-sequential segments.Caenorhabditis elegans clones Y94H6x, * *Check order * *, 15 non-sequential segments.UI-R-AB0-vy-a-01-0-UI.s2 UI-R-AB0 brown rat cDNA clone UI-R-AB0-vy-a-01-0-UI 3 ', the mRNA sequence.Intestinal bacteria minute chromosome 6-8.Salmonella typhimurium propionic acid catabolism operon: RpoN activator homologue (prpR), carboxyl phosphoenolpyruvic acid transphosphorylase homologue (prpB), Oxalacetic transacetase homologue (prpC).PrpD and prpE gene, complete cds.E. coli k-12 MG1655,30 of the selections of 400 complete genome groups.AU068253 Rice callus rice cDNA clones C12658_9A, mRNA sequence.EST72922 Ovary II people cDNA 5 ' end, the mRNA sequence.AU068253 Rice callus rice cDNA clones C12658_9A, mRNA sequence.Starch skin pseudomonas ORF 1 DNA.Starch skin pseudomonas ORF 1 DNA.Arabidopsis thaliana chromosome III BAC T16O11 genome sequence, complete sequence.Arabidopis thaliana 81kb genome sequence.Arabidopsis thaliana chromosome III BAC T16O11 genome sequence, complete sequence.Human chromosome 4 clone B241P19map 4q25, complete sequence.Arabidopis thaliana 81kb genome sequence.Arabidopsis thaliana genomic dna, karyomit(e) 3, P1 clone: MLJ15, complete sequence.Human chromosome 19 clone clone CITB-E1_2568A17, * *Check order * *, 40 non-sequential segments.Human chromosome 19 clone clone CITB-E1_2568A17, * *Check order * *, 40 non-sequential segments.The people clones NH0576F01, complete sequence.

Smegma mycobacterium intestinal bacteria Caenorhabditis elegans Caenorhabditis elegans brown rat intestinal bacteria Salmonella typhimurium, (Salmonella typhimurium) intestinal bacteria rice, (Oryza sativa) people's rice starch skin pseudomonas, (Pseudomonas amyloderamosa) starch skin pseudomonas Arabidopis thaliana, (Arabidopsts thaliana) Arabidopis thaliana Arabidopis thaliana people Arabidopis thaliana Arabidopis thaliana people everybody

56,143 48,563 37,889 37,889 40,833 49,688 50,313 49,688 41,333 34,347 41,899 53,912 54,422 38,244 36,091 37,135 36,165 38,732 38,732 37,976 37,976 37,143

91-09-20 99-07-14 99-02-24 99-02-24 99-04-21 99-07-14 99-08-05 98-11-12 99-06-07 97-04-21 99-06-07 95-07-14 95-07-14 99-11-13 97-03-12 99-11-13 98-09-30 97-03-12 99-05-07 99-09-15 99-09-15 99-09-28

Table 4 (continuing)

Rxa00683 rxa00686 rxa00700 rxa00703 rxa00705 rxa00782 rxa00783 rxa00794

1,215 927 927 2,409 1,038 1,005 1,395 1128

GB_BA2：AE000896 GB_IN1：DMBR7A4 GB_EST35：AV163010 GB_HTG2：HSDJ137K 2 GB_HTG2：HSDJ137K 2 GB_EST12：AA284399 GB_EST34：AI785570 GB_EST25：AI256147 GB_BA1：CARCG12 GB_BA1：SC7H2 GB_BA1：MTCY274 GB_BA2：REU60056 GB_GSS15：AQ604477 GB_EST11：AA224340 GB_EST5：N30648 GB_BA1：MTCY10D7 GB_BA1：MLCL373 GB_BA2：AF128399 GB_HTG2：AC008158 GB_HTG2：AC008158 GB_PR3：AC005017 GB_BA1：MTV017

10,707 212,734 273 190,223 190,223 431 454 684 2,079 42,655 39,991 2,520 505 443 291 39,800 37,304 2,842 118,792 118,792 137,176 67200

AE000896 AL109630 AV163010 AL049820 AL049820 AA284399 AI785570 AI256147 X14979 AL109732 Z74024 U60056 AQ604477 AA224340 N30648 Z79700 AL035500 AF128399 AC008158 AC008158 AC005017 AL021897

The base 1189349-1200055 of hot autotrophic methane bacteria complete genome group (102/148 part (section 102/148)).Drosophila melanogaster clone BACR7A4.An AV163010 house mouse C57BL/6J13 days embryo house mouse cDNA clone 3110006J22, the mRNA sequence.Human chromosome 6 clone RP1-137K2map q25.1-25.3, * *Check order * *, non-sequential segments.Human chromosome 6 clone RP1-137K2map q25.1-25.3, * *Check order * *, non-sequential segments.Zs57b04.r1 NCI_CGAP_GCB1 people cDNA clones IMAGE:701551 5 ', mRNA sequence.Uj44d03.x1 Sugano mouse liver mlia house mouse cDNA clones IMAGE:1922789 3 ', is similar to gb:Z28407 60S ribosomal protein L 8 (people); The mRNA sequence.Ui95e12.x1 Sugano mouse liver mlia house mouse cDNA clones IMAGE:1890190 3 ', is similar to gb:Z28407 60S ribosomal protein L 8 (people); The mRNA sequence.The orange green bacterium reactive center gene 1 and 2 of subduing.Streptomyces coelicolor clay 7H2.Mycobacterium tuberculosis H37Rv complete genome group; Sections 126/162.Ralstonia eutropha hydrogenlyase sample albumen (cbbBc) gene, complete cds.People's gene group sperm library D people's gene group clone flat board=2116 of HS_2116_B1_G07_MR CIT approval, row=13, OK=and N, genome summary sequence.Zr14e07.sl Stratagene hNT neurone (#937233) people cDNA clones IMAGE:648804 3 ', mRNA sequence.Yw77b02.s1 Soares_ placenta _ 8-9 week _ 2NbHP 8-9 week people cDNA clone IMAGE:258219 3 ', the mRNA sequence.Mycobacterium tuberculosis H37Rv complete genome group; Sections 44/162.Mycobacterium leprae clay L373.Pseudomonas aeruginosa succinyl CoA synthetase β subunit (sucC) and succinyl CoA synthetase alpha subunit (sucD) gene, complete cds.Human chromosome 17 clone hRPK.42_F_20map 17, * *Check order * *, 14 non-sequential segments.Human chromosome 17 clone hRPK.42_F_20map 17, * *Check order * *, 14 non-sequential segments.The BAC clone GS214N13 of people 7p14-p15, complete sequence.Mycobacterium tuberculosis H37Rv complete genome group; Sections 48/162.

Hot autotrophic methane bacteria, the orange green bacterium of subduing of everybody house mouse house mouse of (Methanobacterium thermoautotrophicum) drosophila melanogaster house mouse people, (Chloroflexus aurantiacus) streptomyces coelicolor A3, (2) everybody bacillus tuberculosis typus humanus Mycobacterium leprae Pseudomonas aeruginosa of mycobacterium tuberculosis Ralstonia eutropha, (Pseudomonas aeruginosa) everybody bacillus tuberculosis typus humanus

38,429 36,454 41,758 38,031 38,031 39,205 41,943 40,791 37,721 56,646 37,369 51,087 39,617 35,129 43,986 63,327 62,300 53,698 35,135 35,135 35,864 40,331

97-11-15 99-07-30 99-07-08 99-12-03 99-12-03 97-08-14 99-07-02 98-11-12 91-04-23 99-08-02 98-06-19 96-10-16 99-06-10 98-03-11 96-01-05 98-06-17 99-08-27 99-03-25 99-07-28 99-07-28 98-08-08 99-06-24

Table 4 (continuing)

Rxa00799 rxa00800 rxa00825 rxa00871 rxa00872 rxa00879 rxa00909 rxa00913

1,767 1,227 1,056 1,077 2,241 955 2118

GB_BA1：MLCB1222 GB_PR2：HS151B14 GB_PL2：AF016327 GB_HTG2：HSDJ319M 7 GB_HTG2：HSDJ319M 7 GB_BA1：MTV022 GB_BA1：AB019513 GB_PL1：SCSFAARP GB_BA1：MTY15C10 GB_BA1：MLCB2548 GB_BA2：AF169031 GB_IN1：CEF23H12 GB_HTG2：AC007263 GB_HTG2：AC007263 GB_BA1：MTV049 GB_PL2：CDU236897 GB_PL1：CAACTIA GB_BA2：AF010496 GB_BA1：RMPHA GB_EST16：C23528 GB_HTG2：AC007734

34,714 128,942 616 128,208 128,208 13,025 4,417 7,008 33,050 38,916 1,141 35,564 167,390 167,390 40,360 1,827 3,206 189,370 7,888 317 188267

AL049491 Z82188 AF016327 AL079341 AL079341 AL021925 AB019513 X68020 Z95436 AL023093 AF169031 Z74472 AC007263 AC007263 AL022021 AJ236897 X16377 AF010496 X93358 C23528 AC007734

Mycobacterium leprae clay B1222.The human DNA sequence of the clone 151B14 of chromosome 22 is contained tethelin 3 receptors (SS3R) gene.Be similar to pseudogene, RAC2 (the C3 Toxins, botulin substrate 2 (P21-RAC2) that RAS is relevant) gene EST, ETS, GSS and the CpG island of the L39 of ribosomal protein, complete sequence.Hordeum vulgare Barperm1 (perm1) mRNA, part cds.Human chromosome 6 clone RP1-319M7map p21.1-21.3, * *Check order * *, non-sequential segments.Human chromosome 6 clone RP1-319M7map p21.1-21.3, * *Check order * *, non-sequential segments.Mycobacterium tuberculosis H37Rv complete genome group; Sections 100/162.Streptomyces coelicolor alcohol dehydrogenase gene and abc transport albumen, complete cds.Saccharomyces Cerevisiae in S FA and ARP gene.Mycobacterium tuberculosis H37Rv complete genome group; Sections 154/162.Mycobacterium leprae clay B2548.Nucleotide epimerase/dehydrase gene, part cds are inferred in the pathogenic mutation of rice Xanthomonas paddy rice.Caenorhabditis elegans clay F23III2, complete sequence.Human chromosome 14 clone BAC 79J20map 14q31, * *Check order * *, 5 sequential segments.Human chromosome 14 clone BAC 79J20map 14q31, * *Check order * *, 5 sequential segments.Mycobacterium tuberculosis H37Rv complete genome group; Sections 81/162.Candida dubliniensis ACT1 gene, exons 1-2.Candida albicans Actin muscle act1 gene.Pod membrane Rhodobacter strain SB1003, the portion gene group.Rhizobium meliloti pha[A, B, C, D, E, F, G] gene.C23528 Japanese flounder spleen Paralichthys olivaceus cDNA clones HB5 (2), mRNA sequence.Human chromosome 18 clone hRPK.44_O_1map 18, * *Check order * *, 18 non-sequential segments.

The red bacterium Sinorhizobium meliloti of Mycobacterium leprae people Hordeum vulgare people bacillus tuberculosis typus humanus's streptomyces coelicolor saccharomyces cerevisiae (Saccharomyces cerevisiae) Much's bacillus Mycobacterium leprae Xanthomonas Oryzae Pv. Oryzae (Xanthomonas oryzae pv.oryzae) Caenorhabditis elegans people bacillus tuberculosis typus humanus Candida dubliniensis candida albicans (Candida albicans) pod membrane (Sinorhizobium meliloti) Paralichthys olivaceus people

61,170 37,455 41,311 36,845 36,845 63,101 41,312 36,288 39,980 39,435 46,232 34,502 35,714 35,714 36,981 38,716 36,610 51,586 48,367 41,640 34,457

99-08-27 99-06-16 97-10-01 99-11-30 99-11-30 98-06-17 98-11-13 94-11-29 98-06-17 99-08-27 99-09-14 99-10-08 99-05-24 99-05-24 98-06-19 99-09-01 93-04-10 98-05-12 99-03-12 99-09-28 99-06-05

Table 4 (continuing)

Rxa00945 rxa00965 rxa00999 rxa01015 rxa01025 rxa01048 rxa01049 rxa01077 rxa01089

1,095 1,575 442 1,119 1,347 1,605 1,494 873

GB_HTG2：AC007734 GB_EST18：AA709478 GB_HTG4：AC010351 GB_HTG4：AC010351 GB_BA1：MTCY05A6 GB_PAT：E13660 GB_BA1：MTCY359 GB_BA1：MLCB1788 GB_BA1：MTV008 GB_BA1：MTV008 GB_BA1：SC7A1 GB_BA1：MSGB1723C S GB_BA1：MLCB637 GB_BA2：AF017444 GB_BA1：BSUB0013 GB_VI：HSV2HG52 GB_HTG2：AC002518 GB_HTG2：AC002518 GB_HTG2：AC002518 GB_PR3：HSDJ653C5 GB_BA1：ECU29579 GB_BA1：ECU29579 GB_GSS8：AQ044021

188,267 406 220,710 220,710 38,631 1,916 36,021 39,228 63,033 63,033 32,039 38,477 44,882 3,067 218,470 154,746 131,855 131,855 131,855 85,237 72,221 72,221 387

AC007734 AA709478 AC010351 AC010351 Z96072 E13660 Z83859 AL008609 AL021246 AL021246 AL034447 L78825 Z99263 AF017444 Z99116 Z86099 AC002518 AC002518 AC002518 AL049743 U29579 U29579 AQ044021

Human chromosome 18 clone hRPK.44_O_1map 18, * *Check order * *, 18 non-sequential segments.Vv34a05.r1 Stratagene house mouse heart (#937316) house mouse cDNA clones IMAGE:1224272 5 ', mRNA sequence.Human chromosome 5 clone CITB-H1_2022B6, * *Check order * *, 68 non-sequential segments.Human chromosome 5 clone CITB-H1_2022B6, * *Check order * *, 68 non-sequential segments.Mycobacterium tuberculosis H37Rv complete genome group; Sections 120/162.The gDNA of coding 6-phosphoric acid grape saccharic acid desaturase.Mycobacterium tuberculosis H37Rv complete genome group; Sections 84/162.Mycobacterium leprae clay B1788.Mycobacterium tuberculosis H37Rv complete genome group; Sections 108/162.Mycobacterium tuberculosis H37Rv complete genome group; Sections 108/162.Streptomyces coelicolor clay 7A1.Mycobacterium leprae clay B1723DNA sequence.Mycobacterium leprae clay B637.Sinorhizobium meliloti NADP dependency malic enzyme (tme) gene, complete cds.Subtilis complete genome group (13/21 part): 2395261-2613730.Herpes simplex types 2 virus (bacterial strain HG52), the complete genome group.Human chromosome X clones bWXD20, * *Check order * *, 11 non-sequential segments.Human chromosome X clones bWXD20, * *Check order * *, 11 non-sequential segments.Human chromosome X clones bWXD20, * *Check order * *, 11 non-sequential segments.The human DNA sequence of the clone 653C5 of karyomit(e) lp21.3-22.3 is contained CA tumor-necrosis factor glycoproteins (DIS435), STS and GSS, complete sequence.The e. coli k-12 genome, about 61-62 minute.The e. coli k-12 genome, about 61-62 minute.CIT-HSP-2318C18.TR CIT-HSP people's gene group clone 2318C18, genome summary sequence.

People house mouse people bacillus tuberculosis typus humanus Corynebacterium glutamicum mycobacterium tuberculosis Mycobacterium leprae mycobacterium tuberculosis mycobacterium tuberculosis streptomyces coelicolor Mycobacterium leprae Mycobacterium leprae Sinorhizobium meliloti subtilis (Bacillus subtilis) herpes simplex types 2 virus (human herpesvirus 2) everybody everybody esherichia coli people

34,457 42,065 36,448 36,448 36,218 98,349 38,520 64,355 39,860 39,120 55,287 56,847 56,676 53,660 37,255 38,081 35,647 35,647 26,180 36,462 41,808 36,130 36,528

99-06-05 97-12-24 99-10-31 99-10-31 98-06-17 98-06-24 98-06-17 99-08-27 98-06-17 98-06-17 98-12-15 96-06-15 98-09-17 97-11-02 97-11-26 98-12-04 97-09-02 97-09-02 97-09-02 99-11-23 95-07-01 95-07-01 98-07-14

Table 4 (continuing)

Rxa01093 rxa01099 rxa01111 rxa01130 rxa0193 rxa01194 rxa01200

1,554 948 541 687 1,572 495

GB_GSS8：AQ042907 GB_GSS8：AQ044021 GB_BA1：CORPYK1 GB_BA1：MTCY01B2 GB_BA1：MIU65430 GB_BA2：AF045998 GB_BA2：AF051846 GB_GSS1：FR0005503 GB_PR3：AC004063 GB_PR3：HS1178121 GB_HTG3：AC009301 GB_HTG3：AC009444 GB_HTG3：AC009444 GB_IN1：DMC66A1 GB_BA1：CGASO19 EM_PAT：E09634 GB_BA1：MLU15186 EM_PAT：E09634 GB_BA1：CGASO19 GB_VI：HEPCRE4B

392 387 2,795 35,938 1,439 780 738 619 177,014 62,268 163,369 164,587 164,587 34,127 1,452 1,452 36,241 1,452 1,452 414

AQ042907 AQ044021 L27126 Z95554 U65430 AF045998 AF051846 Z89313 AC004063 AL109852 AC009301 AC009444 AC009444 AL031227 X76875 E09634 U15186 E09634 X76875 X60570

CIT-HSP-2318D17.TR CIT-HSP people's gene group clone 2318D17, genome summary sequence.CIT-HSP-2318C18.TR CIT-HSP people's gene group clone 2318C18, genome summary sequence.Rod bacillus pyruvate kinase gene, complete cds.Mycobacterium tuberculosis H37Rv complete genome group; Sections 72/162.Mycobacterium intracellulare pyruvate kinase (pykF) gene, complete cds.Corynebacterium glutamicum inositol monophosphate Phosphoric acid esterase (impA) gene, complete cds.Corynebacterium glutamicum ribose phosphoric acid formimino-5-amino-ribose 1-phosphate-4-Imidazole carboxamide isomerase (hisA) gene, complete cds.F.rubripes GSS sequence, clone 079B16aE8, genome summary sequence.Human chromosome 4 clone B3218, complete sequence.The human DNA sequence of the clone RP5-1178121 of chromosome x, complete sequence.The people clones NH0062F14, * *Check order * *, 5 non-sequential segments.The people clones 1_O_3, * *Check order * *, 8 non-sequential segments.The people clones 1_O_3, * *Check order * *, 8 non-sequential segments.Drosophila melanogaster clay 66A1.Corynebacterium glutamicum (ASO 19) ATP enzyme beta subunit gene.Brevibacterium flavum UncD gene, its gene product participates in.Mycobacterium leprae clay L471.Brevibacterium flavum UncD gene, its gene product participates in.Corynebacterium glutamicum (ASO 19) ATP enzyme beta subunit gene.Hepatitis C virus is inferred the geneome RNA (RE4B isolate) of envelope protein.

Everybody drosophila melanogaster Corynebacterium glutamicum Corynebacterium glutamicum Mycobacterium leprae Corynebacterium glutamicum Corynebacterium glutamicum hepatitis C virus of everybody people of everybody Corynebacterium glutamicum mycobacterium tuberculosis Mycobacterium intracellulare (Mycobacterium intracellulare) Corynebacterium glutamicum Corynebacterium glutamicum Fugu rubripes

35,969 44,545 100,00 63,771 67,061 99,615 100,000 37,785 35,835 37,873 37,240 38,416 38,416 38,416 99,931 99,242 39,153 100,000 100,000 36,769

98-07-14 98-07-14 94-12-07 98-06-17 96-12-23 98-02-19 98-03-12 97-03-01 98-07-10 99-12-01 99-08-13 99-08-22 99-08-22 98-10-05 94-10-27 97-10-07 (Rel.52, Created) 95-03-09 97-10-07 (Rel.52, Created) 94-10-27 92-04-05

Table 4 (continuing)

Rxa01201 rxa01202 rxa01204 rxa01216 rxa01225 rxa01227 rxa01242

1,764 1,098 933 1,124 1,563 444 900

GB_BA1：SLATPSYNA GB_BA1：MTCY373 GB_BA1：MLU15186 GB_BA1：SLATPSYNA GB_BA1：SLATPSYNA GB_BA1：MCSQSSHC GB_PL1：AP000423 GB_HTG6：AC009762 GB_HTG6：AC009762 GB_BA1：MTCY10G2 GB_BA2：AF017435 GB_BA1：CCRFLBDB A GB_BA2：AF058302 GB_HTG3：AC007301 GB_HTG3：AC007300 GB_BA1：SERFDXA GB_BA1：MTV005 GB_BA1：MSGY348 GB_PR3：AC005697 GB_HTG3：AC010722 GB_HTG3：AC010722

8,560 35,516 36,241 8,560 8,560 5,538 154,478 164,070 164,070 38,970 4,301 4,424 25,306 165,741 16,541 3,869 37,840 40,056 174,503 160,723 160723

Z22606 Z73419 U15186 Z22606 Z22606 Y09978 AP000423 AC009762 AC009762 Z92539 AF017435 M69228 AF058302 AC007301 AC007301 M61119 AL010186 AD000020 AC005697 AC010722 AC010722

S.lividansi albumen and atp synthase gene.Mycobacterium tuberculosis H37Rv complete genome group: sections 57/162.Mycobacterium leprae clay L417.S.lividansi albumen and atp synthase gene.S.lividansi albumen and atp synthase gene.Pod membrane methyl coccus orfx, orfy, orfz, sqs and shc gene.The Arabidopis thaliana chloroplast genomic dna, complete sequence, bacterial strain: Columbia people clones RP11-114I16, * *Check order * *, 39 non-sequential segments.The people clones RP11-114I16, * *Check order * *, 39 non-sequential segments.Mycobacterium tuberculosis H37Rv complete genome group; Sections 47/162.Turn round demethylation bacillus methanol oxidation gene, glmU sample gene, part cds and orfL2, orfL1, orfR gene, complete cds.Crescent handle bacillus flagellin gene promoter region.Rose yellow streptomycete frenolicin biosynthesis gene family, complete sequence.Drosophila melanogaster chromosome 2 clone BACR04B09 (D576) RPCI-98 04.B.9map 43E12-44F1 bacterial strain y; Cn bw sp, * *Check order * *, 150 non-sequential segments.Drosophila melanogaster chromosome 2 clone BACR04B09 (D576) RPCI-98 04.B.9map 43E12-44F1 bacterial strain y; Cn bw sp, * *Check order * *, 150 non-sequential segments.Red saccharopolyspora Triphosphopyridine nucleotide photoreductase (fdxA) gene, complete cds.Mycobacterium tuberculosis H37Rv complete genome group; Sections 51/162.The sequence of mycobacterium tuberculosis clone y348.Karyomit(e) 17, clone hRPK.138_P_22, complete sequence.The people clones NH0122L09, * *Check order * *, 2 non-sequential segments.The people clones NH0122L09, * *Check order * *, 2 non-sequential segments.

Streptomyces lividans Much's bacillus Mycobacterium leprae Streptomyces lividans Streptomyces lividans pod membrane methyl coccus (Methylococcus capsulatus) Chloroplast arabidopsis people bacillus tuberculosis typus humanus turn round demethylation bacillus (Methylobacterium exorquens) crescent handle bacillus (Caulobacter crescentus) rose yellow streptomycete (Streptomyces roseofulvus) Drosophila melanogaster Drosophila melanogaster red saccharopolyspora (Saccharopolyspora erythraea) Much's bacillus Much's bacillus people everybody

66,269 65,437 39,302 57,087 38,298 37,626 38,395 35,459 36,117 39,064 42,671 41,054 36,205 39,922 39,922 64,908 62,838 61,712 35,373 39,863 39,863

95-05-01 98-06-17 95-03-09 95-05-01 95-05-01 98-05-26 99-09-15 99-12-04 99-12-04 98-06-17 98-03-10 93-04-26 98-06-02 99-08-17 99-08-17 96-03-13 98-06-17 96-12-10 98-10-09 99-09-25 99-09-25

Table 4 (continuing)

Rxa01243 rxa01259 rxa01262 rxa01311 rxa01312 rxa01325 rxa01332

1,083 981 1,284 870 2,142 795 576

GB_GSS10:AQ255057 GB_IN1:CEK05D4 GB_IN1:CEK05D4 GB_BA1:CGLPD GB_HTG4:AC010567 GB_HTG4:AC010567 GB_BA2:AF172324 GB_BA2:ECU78086 GB_BA1:D90841 GB_PR3:AC004103 GB_HTG3:AC007383 GB_HTG3:AC007383 GB_BA2; AE000487 GB_BA1:MTV016 GB_BA1:U00022 GB_HTG4:AC009245 GB_HTG4:AC009245 GB_HTG4:AC009245 GB_HTG6:AC007186 GB:HTG6:AC007147

583 19,000 19,000 1,800 143,287 143,287 14,263 4,759 201,226 144,368 215,529 215,529 13,889 53,662 36,411 215,767 215,767 215,767 225,851 202291

AQ255057 Z92804 Z92804 Y16642 AC010567 AC010567 AF172324 U78086 D90841 AC004103 AC007383 AC007383 AE000487 AL021841 U00022 AC009245 AC009245 AC009245 AC007186 AC007147

Mgxb0008N01r CUGI Rice Blast BAC library Magnaporthe grisea genomic clone mgxb0008N01r, genome summary sequence.Caenorhabditis elegans clay K05D4, complete sequence.Caenorhabditis elegans clay K05D4, complete sequence.Corynebacterium glutamicum lpd gene, complete CDS.Drosophila melanogaster chromosome 3L/69Cl clone RPCI98-1 1N6, * *Check order * *, 70 non-sequential segments.Drosophila melanogaster chromosome 3L/69Cl clone RPCI98-1 1N6, * *Check order * *, 70 non-sequential segments.Intestinal bacteria GalF (galF) gene, part cds; The translocator Wzx of O-antigen repeating unit (wzx), WbnA (wbnA), O-antigen polysaccharase Wzy (wzy), WbnB (wbnB), WbnC (wbnC), WbnD (wbnD), WbnE (wbnE), UDP-Glc-4-epimerase GalE (galE), 6-Phosphogluconic dehydrogenase Gnd (gnd), UDP-Glc-6-desaturase Ugd (ugd) and WbnF (wbnF) gene, complete cds; And chain length decision albumen Wzz (wzz) gene, part cds.Intestinal bacteria supposition uridine-5 '-diphosphate glucose desaturase (ugd) and O-chain length are regulated albumen (wzz) gene, complete cds.Bacillus coli gene group DNA, Kohara clone #351 (45.1-45.5 minute) people Xp22 BAC GS-61913 (genome system people BAC library) complete sequence.The people clones NH0310K15, * *Check order * *, 4 non-sequential segments.The people clones NH0310K15, * *Check order * *, 4 non-sequential segments.377/400 part of e. coli k-12 MG1655 complete genome group.Mycobacterium tuberculosis H37Rv complete genome group; Sections 143/162.Mycobacterium leprae clay L308.Human chromosome 7, * *Check order * *, 24 non-sequential segments.Human chromosome 7, * *Check order * *, 24 non-sequential segments.Human chromosome 7, * *Check order * *, 24 non-sequential segments.Drosophila melanogaster chromosome 2 clone BACR03D06 (D569) RPCI-98 03.D.6map 32A-32A bacterial strain y; Cn bw sp, * *Check order * *, 91 non-sequential segments.Drosophila melanogaster chromosome 2 clone BACR19N18 (D572) RPCI-98 19.N.18map 32A-32A bacterial strain y; Cn bw sp, * *Check order * *, 22 non-sequential segments.

Everybody drosophila melanogaster drosophila melanogaster of everybody people intestinal bacteria mycobacterium tuberculosis Mycobacterium leprae people of Magnaporthe grisea Caenorhabditis elegans Caenorhabditis elegans Corynebacterium glutamicum drosophila melanogaster drosophila melanogaster esherichia coli intestinal bacteria

38,722 35,448 35,694 100,000 37,178 37,178 59,719 59,735 37,904 37,340 36,385 36,385 39,494 46,252 46,368 36,016 36,016 39,618 35,366 35,366

98-10-23 98-11-23 98-11-23 99-02-01 99-10-16 99-10-16 99-10-29 97-11-05 97-03-21 98-04-18 99-09-25 99-09-25 98-11-12 99-06-23 94-03-01 99-11-02 99-11-02 99-11-02 99-12-07 99-12-07

Table 4 (continuing)

Rxa01350 rxa01365 rxa01369 rxa01377 rxa01392 rxa01436 rxa001468

1,107 1,497 1,305 1,209 1,200 1,314 948

GB_HTG3：AC010207 GB_BA2：AF109682 GB_HTG2：AC006759 GB_HTG2：AC006759 GB_BA1：MTY20B11 GB_BA1：XANXANAB GB_GSS10：AQ194038 GB_BA1：MTY20B11 GB_GSS3：B10037 GB_GSS3：B09549 GB_BA1：MTCY71 GB_HTG5：AC007547 GB_HTG5：AC007547 GB_BA2：AF072709 GB_BA1：CGLYSEG GB_PR4：AC005906 GB_BA1：CGPTAACK A GB_BA1：D9086l GB_PAT：E02087 GB_GSS1：HPU60627 GB_EST31：AI701691

207,890 990 103,725 103,725 36,330 3,410 697 36,330 974 1,097 42,729 262,181 262,181 8,366 2,374 185,952 3,657 14,839 1,200 280 349

AC010207 AF109682 AC006759 AC006759 Z95121 M83231 AQ194038 Z95121 B10037 B09549 Z92771 AC007547 AC007547 AF072709 X96471 AC005906 X89084 D90861 E02087 U60627 AI701691

The people clones RPCI11-375120, * *Check order * *, 25 non-sequential segments.Arctic water spirillum malate dehydrogenase (malic acid dehydrogenase) (MDH) gene, complete cds.Caenorhabditis elegans clones Y40G12, * *Check order * *, 8 non-sequential segments.Caenorhabditis elegans clones Y40G12, * *Check order * *, 8 non-sequential segments.Mycobacterium tuberculosis H37Rv complete genome group; Sections 139/162.Xanthomonas campestris phosphoglucomutase and mannose-phosphate mutase (xanA) and phosphomannose isomerase and GDP-seminose pyrophosphorylase (xanB) gene, complete cds.RPCI11-47D24.TJ RPCI-11 people's gene group clone RPCI-11-47D24, genome summary sequence.Mycobacterium tuberculosis H37Rv complete genome group; Sections 139/162.T27A19-T7 TAMU arabidopsis gene group clone T27A19, genome summary sequence.T27A19-T7.1 TAMU arabidopsis gene group clone T21A19, genome summary sequence.Mycobacterium tuberculosis H37Rv complete genome group; Sections 141/162.The people clones RP11-252O18, WORKING DRAFT sequence, 121 non-sequential segments.The people clones RP11-252O18, WORKING DRAFT sequence, 121 non-sequential segments.Streptomyces lividans amplification element AUD4: the supposition transcription regulatory protein, suppose Triphosphopyridine nucleotide photoreductase, suppose Cytochrome P450 oxydo-reductase and supposition oxidoreductase gene, complete cds; And unknown gene.Corynebacterium glutamicum lysE and lysG gene.People 12p13.3 BAC RPCI11-429A20 (Roswell Park ICR people BAC library) complete sequence.Corynebacterium glutamicum pta gene and ackA gene.Bacillus coli gene group DNA, Kohara clones #405 (52.0-52.3 minute).The proteic DNA of coding intestinal bacteria E.C. 2.7.2.1.Helicobacter pylori feoB sample dna sequence dna, genome summary sequence.We81c04.x1 Soares_NFL_T_GBC_S1 people cDNA clones IMAGE:2347494 3 ', is similar to gb:L19686_mal macrophage migration inhibitory factor (people); The mRNA sequence.

People arctic water spirillum, (Aquaspirillum arcticum) Caenorhabditis elegans Caenorhabditis elegans mycobacterium tuberculosis xanthomonas campestris, the excellent bacillus esherichia coli of everybody Streptomyces lividans Corynebacterium glutamicum human glutamic acid of (Xanthomonas campestris) bacillus tuberculosis typus humanus's Arabidopis thaliana Arabidopis thaliana mycobacterium tuberculosis helicobacter pylori, (Helicobacter pylori) people

34,821 58,487 37,963 37,963 38,011 47,726 36,599 36,940 35,284 38,324 39,778 32,658 38,395 55,221 100,000 36,756 100,000 53,041 54,461 39,286 39,412

99-09-16 99-10-19 99-02-25 99-02-25 98-06-17 93-04-26 99-04-20 98-06-17 97-05-14 97-05-14 99-02-10 99-11-16 99-11-16 98-07-08 97-02-24 99-01-30 99-03-23 97-05-29 97-09-29 97-04-09 99-06-03

Table 4 (continuing)

Rxa01478 rxa01482 rxa01534 rxa01535 rxa01550 rxa01562 rxa01569 rxa01570

1,959 1,998 1,530 1,635 1,482 978

GB_EST15：AA480256 GB_BA1：SCI51 GB_BA1：SCE36 GB_BA1：CGU43535 GB_BA1：SC6G4 GB_BA1：U00020 GB_BA1：MTCY77 GB_BA1：MLCB1222 GB_BA1：MTV017 GB_BA1：PAU72494 GB_BA1：D90907 GB_IN2：AF073177 GB_IN2：AF073179 GB_BA1：D78182 GB_BA2：AF079139 GB_BA2：AF087022 GB_BA1：MTCY63 GB_BA2：AF097519

389 40,745 12,581 2,531 41,055 36,947 22,255 34,714 67,200 4,368 132,419 9,534 3,159 7,836 4,342 1,470 38,900 4594

AA480256 AL109848 AL049763 U43535 AL031317 U00020 Z95389 AL049491 AL021897 U72494 D90907 AF073177 AF073179 D78182 AF079139 AF087022 Z96800 AF097519

Ne31f04.s1 NCI_CGAP_Co3 people cDNA clones IMAGE:898975 3 ', is similar to gb:L19686_mal macrophage migration inhibitory factor (people); The mRNA sequence.Streptomyces coelicolor clay 151.Streptomyces coelicolor clay E36.Corynebacterium glutamicum multi-medicine resistance albumen (cmr) gene, complete cds.Streptomyces coelicolor clay 6G4.Mycobacterium leprae clay B229.Mycobacterium tuberculosis H37Rv complete genome group; Sections 146/162.Mycobacterium leprae clay B1222.Mycobacterium tuberculosis H37Rv complete genome group; Sections 48/162.Pseudomonas aeruginosa fumarase (fumC) and the super oxygen thing of Mn enzyme dismutase (sodA) gene, complete cds.Collection born of the same parents cyanobacteria belongs to bacterium PCC6803 complete genome group, 9/27,1056467-1188885.Drosophila melanogaster glycogen Starch phosphorylase (GlyP) gene, complete cds.Drosophila melanogaster glycogen Starch phosphorylase (Glpl) mRNA, complete cds.The Streptococcus mutans DNA of dTDP-rhamnosyl route of synthesis, complete cds.Entrust auspicious in slide fastener mould pikCD operon, complete sequence.Entrust auspicious in slide fastener fungal cell cytochrome p 450 monooxygenase (picK) gene, complete cds.Mycobacterium tuberculosis H37Rv complete genome group; Sections 16/162.Klebsiella pneumonia dTDP-D-glucose 4,6 dehydratases (rmlB), Cori ester thymidine transferring enzyme (rmlA), dTDP-4-ketone-L-rhamnosyl reductase enzyme (rmlD), dTDP-4-ketone-6-DDG 3,5-epimerase (rmlC) and rhamnosyltransferase (wbbL) gene, complete cds.

The sky blue streptomycete A3 of people, (2) streptomyces coelicolor Corynebacterium glutamicum streptomyces coelicolor Mycobacterium leprae mycobacterium tuberculosis Mycobacterium leprae mycobacterium tuberculosis Pseudomonas aeruginosa collection born of the same parents cyanobacteria belongs to bacterium, (Synechocystis sp.) drosophila melanogaster drosophila melanogaster Streptococcus mutans, slide fastener mould in (Streplococcus mutans) committee is auspicious, slide fastener mould mycobacterium tuberculosis Klebsiella pneumonia in (Streptomyces venezuelae) committee is auspicious

39,574 54,141 38,126 41,852 62,149 38,303 38,179 66,208 38,553 52,690 56,487 55,100 56,708 44,050 38,587 38,621 59,035 59,714

97-08-14 99-08-16 99-05-05 97-04-09 98-08-20 94-03-01 98-06-18 99-08-27 99-06-24 96-10-23 99-02-07 99-07-01 99-04-27 99-02-05 98-10-28 98-10-15 98-06-17 98-11-04

Table 4 (continuing)

Rxa01571 rxa01572 rxa01606 rxa01626 rxa01632 rxa01633

723 615 2,799 468 1,128 1206

GB_BA2：NGOCPSPS GB_BA1：AB011413 GB_BA1：AB011413 GB_BA1：AB011413 GB_BA1：AB011413 GB_VI：CFU72240 GB_GSS10：AQ213248 GB_GSS8：AQ070145 GB_PR4：AF152510 GB_PR4：AF152323 GB_PR4：AF152509 GB_HTG4：AC006590 GB_HTG4：AC006590 GB_GSS8：B99182 GB_BA1：BSUB0009 GB_BA1：BSUB0009 GB_HTG2：AC006247

8,905 12,070 12,070 12,070 12,070 4,783 408 285 2,490 4,605 2,712 127,171 127,171 415 208,780 208,780 174368

L09189 AB011413 AB011413 AB011413 AB011413 U72240 AQ213248 AQ070145 AF152510 AF152323 AF152509 AC006590 AC006590 B99182 Z99112 Z99112 AC006247

Meningitis naphthalene Se Shi coccus dTDP-D-glucose 4,6-dehydratase (rfbB), Cori ester thymidine transferring enzyme (rfbA) and rfbC gene, complete cds and UPD-glucose-4-epimerase (galE) pseudogene.The gene of streptococcus cinereus Orf2, Orf3, Orf4, Orf5, AfsA, Orf8, part and complete cds.The gene of streptococcus cinereus Orf2, Orf3, Orf4, Orf5, AfsA, Orf8, part and complete cds.The gene of streptococcus cinereus Orf2, Orf3, Orf4, Orf5, AfsA, Orf8, part and complete cds.The gene of streptococcus cinereus Orf2, Orf3, Orf4, Orf5, AfsA, Orf8, part and complete cds.Choristoneura fumiferana nuclear polyhedrosis virus ETM albumen homologue, 79kDa albumen homologue, 15kDa albumen homologue and GTA albumen homologue gene, people's gene group sperm library D people's gene group clone flat board=3249 row=3 row=B of complete cds, HS_3249_B1_A02_MR CIT approval, genome summary sequence.People's gene group sperm library D people's gene group clone flat board=3207 row=3 row=P of HS_3207_B1_H02_MR CIT approval, genome summary sequence.The short type albumen of people protocadherin γ A3 (variable region sequences of PCDH-γ-A3), complete cds.People protocadherin γ A3 (mRNA of PCDH-γ-A3), complete cds.People PCDH-γ-A3 gene, aberrant splicing, mRNA sequence.Drosophila melanogaster chromosome 2 clone BACR13N02 (D543) RPCI-98 13.N.2map 36E-36E bacterial strain y; Cn bw sp, * *Check order * *, 101 non-sequential segments.Drosophila melanogaster chromosome 2 clone BACR13N02 (D543) RPCI-98 13.N.2map 36E-36E bacterial strain y; Cn bw sp, * *Check order * *, 101 non-sequential segments.With CIT-HSP-2280I13.TR CIT-HSP people's gene group clone 2280I13, genome summary sequence.Bacillus subtilis complete genome group (9/21 part): 1598421-1807200.Bacillus subtilis complete genome group (9/21 part): 1598421-1807200.Drosophila melanogaster chromosome 2 clone BACR48I10 (D505) RPCI-98 48.1.10map 49E6-49F8 bacterial strain y; Cn bw sp, * *Check order * *, 17 non-sequential segments.

Everybody drosophila melanogaster drosophila melanogaster people subtilis subtilis drosophila melanogaster of everybody people of meningitis naphthalene Se Shi coccus (Neisseria meningitidis) streptococcus cinereus (Streptomyces griseus) streptococcus cinereus streptococcus cinereus streptococcus cinereus choristoneura fumiferana nuclear polyhedrosis virus (Choristoneura fumiferana nucleopolyhedrovirus)

58,384 57,500 35,655 57,843 38,119 37,115 34,559 40,351 34,298 34,298 34,298 33,812 33,812 36,111 36,591 34,941 37,037

96-07-30 98-08-07 98-08-07 98-08-07 98-08-07 99-01-29 98-09-18 98-08-05 99-07-14 99-07-22 99-07-14 99-10-19 99-10-19 98-06-26 97-11-26 97-11-26 99-08-02

Table 4 (continuing)

Rxa001695 rxa01702 rxa01743 rxa01744 rxa01745 rxa01758 rxa01814 rxa01851

1,623 1,155 901 1,662 836 1,140 1,785 1809

GB_BA1：CGA224946 GB_BA1：MTCY24A1 GB_IN1：DMU15974 GB_BA1：CGFDA GB_BA1：MTY13E10 GB_BA1：MLCB4 GB_IN2：CELC27115 GB_EST24：AI167112 GB_GSS9：AQ102635 GB_BA1：MTCY01B2 GB_GSS1：AF009226 GB_BA1：SCD78 GB_BA1：MTCY190 GB_BA1：MLCB22 GB_BA2：AE000175 GB_PR3：HS57G9 GB_PL2：YSCH9666 GB_PL2：YSCH9986 GB_BA1：ABCCELB GB_BA1：MTCY22D7 GB_BA1：MTCY22D7 GB_GSS9：AQ142579 GB_IN2：AC005889 GB_GSS1：AG008814

2,408 20,270 2,994 3,371 35,019 36,310 35,840 579 347 35,938 665 36,224 34,150 40,281 15,067 113,872 39,057 41,664 2,058 31,859 31,859 529 108,924 637

AJ224946 Z95207 U15974 X17313 Z95324 AL023514 U14635 AI167112 AQ102635 Z95554 AF009226 AL034355 Z70283 Z98741 AE000175 Z95116 U10397 U00027 L24077 Z83866 Z83866 AQ142579 AC005889 AG008814

Corynebacterium glutamicum L MALIC ACID: quinone oxidoreductase DNA.Mycobacterium tuberculosis H37Rv complete genome group; Sections 124/162.Drosophila melanogaster kinesin sample albumen (klp68d) mRNA, complete cds.Corynebacterium glutamicum fructose-bis phosphate aldolase fda gene (EC 4.1.213).Mycobacterium tuberculosis H37Rv complete genome group; Sections 18/162.Mycobacterium leprae clay B4.Caenorhabditis elegans clay C27H5.Xylem.est.878 willow xylem λ ZAPII library Populus balsamifera subsp. trichocarpa cDNA 5 ', the mRNA sequence.People's gene group sperm library D people's gene group clone flat board=3048 row=15 row=L of HS_3048_B1_F08_MF CIT approval, genome summary sequence.Mycobacterium tuberculosis H37Rv complete genome group; Sections 72/162.Mycobacterium tuberculosis cytopigment D oxidase subunit I (appC) gene, partial sequence, genome summary sequence.Streptomyces coelicolor clay D78.Mycobacterium tuberculosis H37Rv complete genome group; Sections 98/162.Mycobacterium leprae clay B22.65/400 part of e. coli k12 MG1655 complete genome group.The human DNA sequence of the BAC 57G9 of chromosome 22 q12.1 is contained EST, CA tumor-necrosis factor glycoproteins, GSS.Yeast saccharomyces cerevisiae karyomit(e) VIII clay 9666.Yeast saccharomyces cerevisiae karyomit(e) VIII clay 9986.Acetobacter xylinum phosphoglucomutase (celB) gene, complete cds.Mycobacterium tuberculosis H37Rv complete genome group; Sections 133/162.Mycobacterium tuberculosis H37Rv complete genome group; Sections 133/162.People's gene group sperm library D people's gene group clone flat board=2222 row=5 row=P of HS_ 2222_B1_H03_MR CIT approval, genome summary sequence.Drosophila melanogaster, karyomit(e) 2L, 30A3-30A6 district, P1 clone DS06958 and DS03097, complete sequence.The human gene group DNA, 21q district, clone: B137B7BB68, genome summary sequence.

Corynebacterium glutamicum Much's bacillus Drosophila melanogaster Corynebacterium glutamicum Much's bacillus Mycobacterium leprae Caenorhabditis elegans Populus balsamifera subsp. trichocarpa bacillus tuberculosis typus humanus's Much's bacillus streptomyces coelicolor Much's bacillus Mycobacterium leprae Escherichia coli people's saccharomyces cerevisiae saccharomyces cerevisiae acetobacter xylinums (Acelobacter xylinus) Much's bacillus Much's bacillus people Drosophila melanogaster people

100,000 38,626 36,783 99,913 38,786 38,238 35,334 39,222 40,653 36,650 63,438 53,088 62,081 61,364 52,323 39,209 40,021 34,375 62,173 39,749 40,034 38,068 36,557 35,316

98-08-11 98-06-17 95-07-18 93-09-12 98-06-17 99-08-27 95-07-13 98-12-03 98-08-27 98-06-17 97-07-31 98-11-26 98-06-17 97-08-22 98-11-12 99-11-23 97-09-05 97-08-29 94-09-21 98-06-17 98-06-17 98-09-24 98-10-30 99-02-07

Table 4 (continuing)

Rxa01859 rxa01865 rxa01882 rxa01884 rxa01886 rxa01887 rxa01888

1,050 438 1,113 1,913 897 1,134 658

GB_BA2：AF183408 GB_HTG5：AC008031 GB_BA2：AF183408 GB_BA1：SERFDXA GB_BA1：MTV005 GB_BA1：MSGY348 GB_PR1：HUMADRA2 C GB_PR4：HSU72648 GB_GSS3：B42200 GB_BA1：MTCY48 GB_BA1：SCO001206 GB_BA1：D90908 GB_GSS9：AQ116291 GB_BA2：AE001721 GB_EST16：AA567090 GB_HTG6：AC008147 GB_HTG6：AC008147 GB_BA2：ALW243431 GB_HTG2：AC008197

63,626 158,889 63,626 3,869 37,840 40,056 1,491 4,850 387 35,377 9,184 122,349 572 17,632 596 303,147 303,147 26,953 125235

AF183408 AC008031 AF183408 M61119 AL010186 AD000020 J03853 U72648 B42200 Z74020 AJ001206 D90908 XQ116291 AE001721 AA567090 AC008147 AC008147 AJ243431 AC008197

Verdigris micro-capsule cyanobacteria dna polymerase i II β subunit (dnaN) gene, part cds; Microcystin synthase gene bunch, complete sequence; Uma1 (uma1), Uma2 (uma2), Uma3 (uma3), Uma4 (uma4) and Uma5 (uma5) gene, complete cds and Uma6 (uma6) gene, part cds.Bu Lusishi trypanosome karyomit(e) II clones RPCI93-25N14, * *Check order * *, 2 non-sequential segments.Verdigris micro-capsule cyanobacteria dna polymerase i II β subunit (dnaN) gene, part cds; Microcystin synthase gene bunch, complete sequence; Uma1 (uma1), Umna2 (uma2), Uma3 (uma3), Uma4 (uma4) and Uma5 (uma5) gene, complete cds and Uma6 (uma6) gene, part cds.Red saccharopolyspora Triphosphopyridine nucleotide photoreductase (fdxA) gene, complete cds, mycobacterium tuberculosis H37Rv complete genome group; The sequence of sections 51/162, mycobacterium tuberculosis clone y348.People's kidney α-2-adrenergic receptor gene, complete cds.People's kidney α 2-C4-adrenergic receptor gene, complete cds.People's gene group sperm library C people's gene group clone flat board=CT 777 row=5 row=B of HS_1055_B1_A03_MR.abi CIT approval, genome summary sequence.Mycobacterium tuberculosis H37Rv complete genome group; Sections 69/162.Streptomyces coelicolor A3 (2), Glycogen Metabolism bunch II.Collection born of the same parents cyanobacteria belongs to bacterium PCC6803 complete genome group, 10/27,1188886-1311234.RPCI11-49P6.TK.1 RPCI-11 people's gene group clone RPCI-11-49P6, genome summary sequence.33/136 part of Thermotoga maritima complete genome group.GM01044.5prime GM drosophila melanogaster ovary BlueScript drosophila melanogaster cDNA clones GM01044.5prime, mRNA sequence.The people clones RP3-405J10, * *Check order * *, 102 non-sequential segments.The people clones RP3-405J10, * *Check order * *, 102 non-sequential segments.Acinetobacter lwoffii wzc, wzb, wza, weeA, weeB, wceC.Wzx, wzy, weeD, weeE, weeF, weeG, weeH, weeI, weeJ, weeK, glaU, ugd, pgi, galE, pgm (part) and nip (part) gene (1 bunch of emulsion adhesive biosynthesis gene), bacterial strain RAG-1.Drosophila melanogaster chromosome 3 clone BACR02L12 (D753) RPCI-98 02.L.12map 94B-94C bacterial strain y; Cn bw sp, * *Check order * *, 113 non-sequential segments.

Verdigris micro-capsule cyanobacteria, (Mycrocystis aeruginosa) Bu Lusishi trypanosome, everybody bacillus tuberculosis typus humanus's streptomyces coelicolor collection born of the same parents basket bacterium of (Trypanosoma brucei) verdigris micro-capsule cyanobacteria red saccharopolyspora mycobacterium tuberculosis mycobacterium tuberculosis belongs to the bacterium sea of faces thermobacillus of dwelling, everybody acinetobacter lwoffii of (Thermotoga maritima) drosophila melanogaster, (Acinetobacter lwoffii) drosophila melanogaster

36,364 35,334 36,529 59,862 61,949 59,908 36,899 36,899 34,805 37,892 40,413 47,792 43,231 39,306 42,807 36,417 37,667 39,640 32,969

99-10-03 99-11-15 99-10-03 96-03-13 98-06-17 96-12-10 93-04-27 98-11-23 97-10-18 98-06-17 99-03-29 99-02-07 99-04-20 99-06-02 98-11-28 99-12-03 99-12-03 99-10-01 99-08-02

Table 4 (continuing)

Rxa01891 rxa01895 rxa01901 rxa01927 rxa01952 Rxa01989 rxa02026 rxa02028

887 1,051 1,383 1,503 1,836 630 720 526

GB_HTG2：AC008197 GB_EST36：A1881527 GB_VI：HIV232971 GB_PL1：AFCHSE GB_PR3：AF064858 GB_BA1：CGL238250 GB_BA2：AF038423 GB_BA1：MTCY359 GB_BA1：MSG38COS GB_BA1：SCE63 GB_PR3：AF093117 GB_BA1：CGPAN GB_BA1：ASXYLA GB_HTG3：AC009500 GB_BA2：AE000739 GB_EST28：AI519629 GB_EST21：AA949396 GB_BA1：BSPGIA GB_BA1：BSUB0017 GB_BA2：AF132127 GB_BA1：SXSCRBA GB_BA1：BSUB0020 GB_BA1：BSGENR GB_BA1：MTC1237

12,535 598 621 6,158 193,387 1,593 1,376 36,021 37,114 37,200 147,216 2,164 1,905 176,060 13,335 612 767 1,822 217,420 8,452 3,161 212,150 97,015 27030

AC008197 A1881527 AJ232971 Y09542 AF064858 AJ238250 AF038423 Z83859 L01095 AL035640 AF093117 X96580 X59466 AC009500 AE000739 AI519629 AA949396 X16639 Z99120 AF132127 X67744 Z99123 X73124 Z94752

Drosophila melanogaster chromosome 3 clone BACR02L12 (D753) RPCI-98 02.L.12map 94B-94C bacterial strain y; Cn bw sp, * *Check order * *, 113 non-sequential segments.606070C09.y1 606-Schmidt lab Zea mays cDNA and fringe tissue cDNA library, the mRNA sequence.I type human immunodeficiency virus C hypotype nef gene, patient MP83.Aspergillus fumigatus chsE gene.Human chromosome 21q22.3 BAC 28F9, complete sequence.Corynebacterium glutamicum ndh gene.Smegma mycobacterium nadh dehydrogenase (ndh) gene, complete cds.Mycobacterium tuberculosis H37Rv complete genome group; Sections 84/162.The Mycobacterium leprae genomic dna sequence, clay B35bfr gene, complete cds.Streptomyces coelicolor clay E63.Human chromosome 7qtelo BAC E3, complete sequence.Corynebacterium glutamicum panB, panC ﹠amp; The xylB gene.The xylA gene people of genus arthrobacter bacterium N.R.R.L.B3728D-wood sugar (D-glucose) isomerase clones NH0511A20, * *Check order * *, 6 non-sequential segments.71/109 part of Aquifex aeolicus complete genome group.LD39282.5prime LD drosophila melanogaster embryo pOT2 drosophila melanogaster cDNA clones LD39282.5prime, mRNA sequence.LD28277.5prime LD drosophila melanogaster embryo pOT2 drosophila melanogaster cDNA clones LD28277.5prime, mRNA sequence.The pgiA gene of bacstearothermophilus glucose phosphate isomerase A (EC 5.3.19).Subtilis complete genome group (17/21 part): 3197001-3414420.Pure phosphoenolpyruvic acid is ploughed on the Streptococcus mutans mountain: sugar phosphotransferase operon, complete sequence and unknown gene.Staphylococcus xylosus scrB and scrR gene.Subtilis complete genome group (20/21 part): 3798401-4010550.Subtilis genome section (325-333) mycobacterium tuberculosis H37Rv complete genome group; Sections 46/162.

Drosophila melanogaster maize (Zea mays) I type human immunodeficiency virus aspergillus fumigatus (Aspergillus fumigatus) human glutamic acid rod bacillus smegma mycobacterium Much's bacillus Mycobacterium leprae streptomyces coelicolor human glutamic acid rod bacillus Arthrobacter bacterium (Arthrobacter sp.) people Aquifex aeolicus Drosophila melanogaster Drosophila melanogaster bacillus stearothermophilus bacillus subtilis Streptococcus mutans staphylococcus xylosus (Staphylococcus xylosus) bacillus subtilis bacillus subtilis Much's bacillus

32,969 43,617 40,040 37,844 37,136 100,000 65,254 40,058 59,551 39,468 39,291 38,384 56,283 37,593 36,309 41,941 39,855 66,292 37,255 63,607 67,778 35,574 51,826 54,476

99-08-02 99-07-21 99-03-05 97-04-01 98-06-02 99-04-24 98-05-05 98-06-17 94-09-06 99-03-17 98-10-02 99-05-11 92-05-04 99-08-24 98-03-25 99-03-16 98-11-25 95-04-20 97-11-26 99-09-28 96-11-28 97-11-26 93-11-02 98-06-17

Table 4 (continuing)

Rxa02054 rxa02056 rxa02061 rxa02063 rxa02100 rxa02122 rxa02140 rxa02142

1,140 2,891 1,617 1,350 2,348 822 1,200 774

GB_PL2：SCE9537 GB_GSS13：AQ501177 GB_BA1：MLCB1222 GB_BA1：MTY13E12 GB_BA1：MTU43540 GB_PAT：E14601 GB_BA1：D84102 GB_BA1：MTV006 GB_HTG7：AC005883 GB_PL2：ATAC003033 GB_PL2：ATAC002334 GB_BA1：SCGLGC GB_GSS4：AQ687350 GB_EST38：AW028530 GB_BA1：MSGY151 GB_BA1：MTCY130 GB_BA1：SCO001205 GB_BA1：D90858 GB_EST37：AI948595 GB_HTG3：AC010387 GB_BA1：MSGB1551C S GB_BA1：MSGB1554C S GB_RO：AF093099 GB_BA1：MTCY190

66,030 767 34,714 43,401 3,453 4,394 4,394 22,440 211,682 84,254 75,050 1,518 786 444 37,036 32,514 9,589 13,548 469 220,665 36,548 36,548 2,482 34150

U18778 AQ501177 AL049491 Z95390 U43540 E14601 D84102 AL021006 AC005883 AC003033 AC002334 X89733 AQ687350 AW02853 0 AD000018 Z73902 AJ001205 D90858 AI948595 AC010387 L78813 L78814 AF093099 Z70283

Yeast saccharomyces cerevisiae karyomit(e) V clay 9537,9581,9495,9867 and λ clone 5898.V26G9mTn-3xHA/lacZ inserts library genes of brewing yeast group 5 ', genome summary sequence.Mycobacterium leprae clay B1222.Mycobacterium tuberculosis H37Ry complete genome group; Sections 147/162.Mycobacterium tuberculosis rfbA, rhamnosyl biosynthesizing albumen (rfbA) and rmlC gene, complete cds.Brevibacterium α-ketone group glutamate dehydrogenase.Corynebacterium glutamicum 2-oxo glutamate dehydrogenase DNA, complete cds.Mycobacterium tuberculosis H37Rv complete genome group; Sections 54/162.Human chromosome 17 clone RP11-958E11map 17, * *Check order * *, 2 sequential segments.Arabidopsis thaliana chromosome II BAC T21L14 genome sequence, complete sequence.Arabidopsis thaliana chromosome II BAC F25I18 genome sequence, complete sequence.The DNA of streptomyces coelicolor glgC gene.Nbxb0074H1 1rCUGI rice BAC library rice genomic clone nbxb0074H1 1r, genome summary sequence.Wv27f10.x1 NCI_CGAP_Kid11 people cDNA clones IMAGE:2530795 3 ', is similar to WP:T03G11.6 CE04874; The mRNA sequence.The sequence of mycobacterium tuberculosis clone y151.Mycobacterium tuberculosis H37Rv complete genome group; Sections 59/162.Streptomyces coelicolor A3 (2) Glycogen Metabolism bunch I.Bacillus coli gene group DNA, Kohara clone #401 (51.3-51.6 minute) wq07d12.x1 NCI_CGAP_Kid12 people cDNA clone IMAGE:2470583 3 '; The mRNA sequence.Human chromosome 5 clone CITB-H1_2074D8, * *Check order * *, 77 non-sequential segments.Mycobacterium leprae clay B1551DNA sequence.Mycobacterium leprae clay B1554DNA sequence.House mouse transcription factor TBLYM (Tblym) mRNA, complete cds.Mycobacterium tuberculosis H37Rv complete genome group; Sections 98/162.

Everybody Mycobacterium leprae Mycobacterium leprae house mouse mycobacterium tuberculosis of yeast saccharomyces cerevisiae yeast saccharomyces cerevisiae Mycobacterium leprae mycobacterium tuberculosis mycobacterium tuberculosis Corynebacterium glutamicum Corynebacterium glutamicum mycobacterium tuberculosis people Arabidopis thaliana Arabidopis thaliana streptomyces coelicolor rice bacillus tuberculosis typus humanus mycobacterium tuberculosis streptomyces coelicolor intestinal bacteria

36,100 32,039 61,896 59,964 59,659 98,928 98,928 39,265 37,453 37,711 37,711 56,972 40,696 36,795 40,156 55,218 38,475 38,586 37,259 38,868 51,399 51,399 36,683 57,292

97-08-01 99-04-29 99-08-27 98-06-17 97-08-14 99-07-28 99-02-06 98-06-18 99-12-08 97-12-19 98-03-04 99-07-12 99-07-01 99-10-27 96-12-10 98-06-17 99-03-29 97-05-29 99-09-06 99-09-15 96-06-15 96-06-15 99-10-01 98-06-17

Table 4 (continuing)

Rxa02143 rxa02144 rxa02147 rxa02149 rxa02175 rxa02196 rxa02209

1,011 1,347 1,140 1,092 1,416 816 1694

GB_BA1：SC6G10 GB_BA1：AB016787 GB_BA1：MTCY190 GB_BA1：MSGB1551C S GB_BA1：MSGB1554C S GB_BA1：MTCY190 GB_HTG3：AC011500_ 0 GB_HTG3：AC011500_ 0 GB_EST28：AI492095 GB_EST10：AA15767 GB_EST10：AA15767 GB_PR3：HSBK277P6 GB_BA2：EMB065R07 5 GB_EST34：AI789323 GB_BA1：CGGLTG GB_BA1：MTCY31 GB_BA1：MLCB57 GB_RO：RATDAPRP GB_GSS8：AQ012162 GB_RO：RATDAPRP GB_BA1：AB025424 GB_BA2：AF002133

36,734 5,550 34,150 36,548 36,548 34,150 300,851 300,851 485 376 376 61,698 360 574 3,013 37,630 38,029 2,819 763 2,819 2,995 15437

AL049497 AB016787 Z70283 L78813 L78814 Z70283 AC011500 AC011500 AI492095 AA157467 AA157467 AL117347 AF116423 AI789323 X66112 Z73101 Z99494 M76426 AQ012162 M76426 AB025424 AF002133

Streptomyces coelicolor clay 6G10.Gene and the 2ORF of pseudomonas putida cytopigment o ubiquinol oxydase A-E, complete cds.Mycobacterium tuberculosis H37Rv complete genome group; Sections 98/162.Mycobacterium leprae clay B1551DNA sequence.Mycobacterium leprae clay B1554DNA sequence.Mycobacterium tuberculosis H37Rv complete genome group; Sections 98/162.Human chromosome 19 clone CIT978SKB_60E11, * *Check order * *, 246 non-sequential segments.Human chromosome 19 clone CIT978SKB_60E11, * *Check order * *, 246 non-sequential segments.Tg07a01.x1 NCI_CGAP_CLL1 people cDNA clones IMAGE:2108040 3 '; The mRNA sequence.Zo50e01.r1 Stratagene endotheliocyte 937223 people cDNA clone IMAGE:5903285 ': the mRNA sequence.Zo50e01.r1 Stratagene endotheliocyte 937223 people cDNA clone IMAGE:5903285 '; The mRNA sequence.The human DNA sequence of the clone 277P6 of karyomit(e) lq253-312, complete sequence.Rhizobium etli mutant MB045 RosR-transcriptional regulatory sequences.Uk53g05.y1 Sugano mouse kidney mkia house mouse cDNA clones IMAGE:1972760 5 ', is similar to WP:K11H12.8CE12160; The mmRNA sequence.Corynebacterium glutamicum Oxalacetic transacetase glt gene and ORF.Mycobacterium tuberculosis H37Rv complete genome group; Sections 41/162.Mycobacterium leprae clay B57.Brown rat two peptidyl aminopeptidase associated protein (dpp6) mRNA, complete cds.The red bacterial genomes clone of 127PB037070197 karyomit(e) II cosmid library class ball 127PB037070197, genome summary sequence.Brown rat two peptidyl aminopeptidase associated protein (dpp6) mRNA, complete cds.Corynebacterium glutamicum aconitase gene, part cds.Mycobacterium avium bacterial strain GIR10 transcription regulatory protein (mav81) gene, part cds, aconitase (acn), invasion 1 (inv1), invasion 2 (inv2), transcription regulatory protein (moxR), ketoacyl base reductase enzyme (fabG), enoyl reductase (inhA) and ferrochelatase (mav272) gene, complete cds.

Streptomyces coelicolor pseudomonas putida (Pseudomonas putida) mycobacterium tuberculosis Mycobacterium leprae Mycobacterium leprae mycobacterium tuberculosis everybody everybody everybody Rhizobium etli house mouse Corynebacterium glutamicum mycobacterium tuberculosis Mycobacterium leprae brown rat class ball red bacterium brown rat Corynebacterium glutamicum mycobacterium avium (Mycobacterium avium)

35,058 47,403 57,317 38,159 38,159 55,530 39,659 39,659 39,798 36,436 36,436 36,872 43,175 39,715 100,000 64,331 62,491 38,791 40,044 37,312 99,173 40,219

99-03-24 99-08-05 98-06-17 96-06-15 96-06-15 98-06-17 00-02-18 00-02-18 99-03-30 96-12-11 96-12-11 99-11-23 99-12-06 99-07-02 95-02-17 98-06-17 99-02-10 95-05-31 98-06-04 95-05-31 99-04-03 98-03-26

Table 4 (continuing)

Rxa02213 rxa02245 rxa02256 rxa02257 rxa02258 rxa02259

874 780 1,125 1,338 900 2895

GB_BA1：MTV007 GB_BA1：AB025424 GB_BA1：MTV007 GB_BA2：AF002133 GB_BA2：RCU23145 GB_BA1：ECU82664 GB_HTG2：AC007922 GB_BA1：CGGAPPGK GB_BA1：SCC54 GB_BA1：MTCY493 GB_BA1：CGGAPPGK GB_BA1：MTCY493 GB_BA2：MAU82749 GB_BA1：CGGAPPGK GB_BA1：CORPEPC GB_PAT：A09073 GB_BA1：CORPEPC GB_PAT：A09073 GB_BA1：CGPPC

32,806 2,995 32,806 15,437 5,960 139,818 158,858 3,804 30,753 40,790 3,804 40,790 2,530 3,804 4,885 4,885 4,885 4,885 3292

AL021184 AB025424 AL021184 AF002133 U23145 U82664 AC007922 X59403 AL035591 Z95844 X59403 Z95844 U82749 X59403 M25819 A09073 M25819 A09073 X14234

Mycobacterium tuberculosis H37Rv complete genome group; Sections 64/162.Corynebacterium glutamicum aconitase gene, part cds.Mycobacterium tuberculosis H37Rv complete genome group; Sections 64/162.Mycobacterium avium bacterial strain GIR10 transcription regulatory protein (mav81) gene, part cds, aconitase (acn), invasion 1 (inv1), invasion 2 (inv2), transcription regulatory protein (moxR), ketoacyl base reductase enzyme (fabG), enoyl reductase (inhA) and ferrochelatase (mav272) gene, complete cds.The red bacterium Calvin cycle of pod membrane carbon dioxide fixation operon: fructose-1,6-/sedoheptulose-1,7-bisphosphate aldolase (cbbA) gene, part cds, II type ribulose-1,5-bisphosphate, 5-bisphosphate carboxylase/oxygenase (cbbM) gene, complete cds and Calvin cycle operon: pentose-5-phosphoric acid-3-epimerization alcohol (cbbE), phosphoglycerate phosphatase (cbbZ) and cbbY gene, complete cds.Intestinal bacteria 9-11 minute genome sequence.Human chromosome 18 clone hRPK.178_F_10map 18, * *Check order * *, 11 sequential segments.The gap of Corynebacterium glutamicum glyceraldehyde-3-phosphate, phosphoglyceric kinase and triose-phosphate isomerase, pgk and tpi gene.Streptomyces coelicolor clay C54.Mycobacterium tuberculosis H37Rv complete genome group; Sections 63/162.The gap of Corynebacterium glutamicum glyceraldehyde-3-phosphate, phosphoglyceric kinase and triose-phosphate isomerase, pgk and tpi gene.Mycobacterium tuberculosis H37Rv complete genome group; Sections 63/162.Mycobacterium avium glyceraldehyde-3-phosphate, desaturase homologue (gapdh) gene, complete cds; And phosphoglyceric kinase gene, part cds.The gap of Corynebacterium glutamicum glyceraldehyde-3-phosphate, phosphoglyceric kinase and triose-phosphate isomerase, pgk and tpi gene.Corynebacterium glutamicum Phosphoenolpyruvate carboxylase gene.Corynebacterium glutamicum Phosphoenolpyruvate carboxylase ppg gene.Corynebacterium glutamicum Phosphoenolpyruvate carboxylase gene, complete cds.Corynebacterium glutamicum Phosphoenolpyruvate carboxylase ppg gene.Corynebacterium glutamicum Phosphoenolpyruvate carboxylase gene (EC 4.1.1.31).

The red bacteria Escherichia coli human glutamic acid rod of mycobacterium tuberculosis Corynebacterium glutamicum mycobacterium tuberculosis mycobacterium avium pod membrane bacillus streptomyces coelicolor mycobacterium tuberculosis Corynebacterium glutamicum mycobacterium tuberculosis mycobacterium avium Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum

38,253 99,096 34,937 36,885 48,701 39,119 33,118 99,289 36,951 64,196 98,873 61,273 61,772 99,667 100,000 100,000 100,000 100,000 99,827

98-06-17 99-04-03 98-06-17 98-03-26 97-10-28 97-01-11 99-06-26 92-10-05 99-06-11 98-06-19 92-10-05 98-06-19 98-01-06 92-10-05 95-12-15 93-08-25 95-12-15 93-08-25 93-09-12

Table 4 (continuing)

Rxa02288 rxa02292 rxa02322 rxa02326 rxa02327 rxa02328 rxa02332 rxa02333

969 798 511 939 1,083 1,719 1,266 1038

GB_PR3：HSD194E24 GB_HTG3：AC010091 GB_HTG3：AC010091 GB_BA2：AF125164 GB_GSS5：AQ744695 GB_EST14：AA381925 GB_BA1：MTCY22G8 GB_BA1：MTCY22G8 GB_BA1：CGPYC GB_BA2：AF038548 GB_BA1：MTCY349 GB_BA1：CGPYC GB_BA2：AF03848 GB_BA1：MTCY349 GB_BA1：CGPYC GB_BA2：AF038548 GB_PL2：AF097728 GB_BA1：MSGLTA GB_BA2：ABU85944 GB_BA2：AE000175 GB_BA1：MSGLTA GB_PR4：HUAC00229 9

243,145 159,526 159,526 26,443 827 309 22,550 22,550 3,728 3,637 43,523 3,728 3,637 43,523 3,728 3,637 3,916 1,776 1,334 15,067 1,776 171681

AL050317 AC010091 AC010091 AF125164 AQ744695 AA381925 Z95585 Z95585 Y09548 AF038548 Z83018 Y09548 AF038548 Z83018 Y09548 AF038548 AF097728 X60513 U85944 AE000175 X60513 AC002299

The human DNA sequence of the clone RP1-94E24 of karyomit(e) 20q12, complete sequence.The people clones NH0295A01, * *Check order * *, 4 non-sequential segments people clone NH0295A01, * *Check order * *, 4 non-sequential segments bacteroides fragilis 638R Polysaccharide Bs (PSB2) biosynthesis gene seat, complete sequence; And unknown gene.HS_5505_A2_C06_SRPCI-11 male sex BAC library people's gene group clone flat board=1081 row=12 row=E, genome summary sequence.EST95058 activating T cell people cDNA 5 ' does not hold, the mRNA sequence.Mycobacterium tuberculosis H37Rv complete genome group; Sections 49/162.Mycobacterium tuberculosis H37Rv complete genome group; Sections 49/162.Corynebacterium glutamicum pyc gene.Corynebacterium glutamicum pyruvate carboxylase (pyc) gene, complete cds.Mycobacterium tuberculosis H37Rv complete genome group; Sections 131/162.Corynebacterium glutamicum pyc gene.Corynebacterium glutamicum pyruvate carboxylase (pyc) gene, complete cds.Mycobacterium tuberculosis H37Rv complete genome group; Sections 131/162.Corynebacterium glutamicum pyc gene.Corynebacterium glutamicum pyruvate carboxylase (pyc) gene, complete cds.Terreus pyruvate carboxylase (Pyc) mRNA, complete cds.Smegma mycobacterium Oxalacetic transacetase gltA gene.South Pole bacterium DS2-3R Oxalacetic transacetase (cisy) gene, complete cds.65/400 part of e. coli k-12 MG1655 complete genome group.Smegma mycobacterium Oxalacetic transacetase gltA gene.Human chromosome 16BAC clones CIT987-SKA-113A6～complete genome group sequence, complete sequence.

Everybody bacteroides fragilis of people, (Bacteroides fragilis) people bacillus tuberculosis typus humanus mycobacterium tuberculosis Corynebacterium glutamicum Corynebacterium glutamicum mycobacterium tuberculosis Corynebacterium glutamicum Corynebacterium glutamicum mycobacterium tuberculosis Corynebacterium glutamicum Corynebacterium glutamicum terreus, (Aspergillus terreus) smegma mycobacterium South Pole bacterium, (Antarctic bacterium) DS2-3R intestinal bacteria smegma mycobacterium people

36,039 35,331 35,331 39,747 39,185 35,922 57,677 37,143 100,000 100,000 37,363 99,259 99,259 41,317 100,000 100,000 52,248 58,460 57,154 38,164 58,929 33,070

99-12-03 99-09-11 99-09-11 99-12-01 99-07-16 97-04-21 98-06-17 98-06-17 98-05-08 97-12-24 98-06-17 98-005-08 97-12-24 98-06-17 98-05-08 97-12-24 98-10-29 91-09-20 97-09-23 98-11-12 91-09-20 99-11-23

Table 4 (continuing)

Rxa02399 rxa02404 rxa02414 rxa02435 rxa02440 rxa02453 rxa02474 rxa02480

1,467 2,340 870 681 963 876 897 1779

GB_HTG2：AC007889 GB_BA1：CGACEA GB_BA1：CORACEA GB_PAT：I13693 GB_BA1：CGACEB GB_BA1：CORACEB GB_BA1：PFFC2 GB_PR4：AC007102 GB_HTG3：AC011214 GB_HTG3：AC011214 GB_BA2：AF101055 GB_OM：RABPKA GB_OM：RABPLASIS M GB_EST14：AA417723 GB_EST11：AA215428 GB_BA1：MTCY77 GB_EST14：AA426336 GB_BA1：STMAACC8 GB_PR3：AC004500 GB_BA1：AB009078 GB_OM：BTU71200 GB_EST2：F12685 GB_BA1：MTV012

127,840 2,427 1,905 2,135 3,024 2,725 5,588 176,258 183,414 183,414 7,457 4,441 4,458 374 303 22,255 375 1,353 77,538 2,686 877 287 70287

AC007889 X75504 L28760 I13693 X78491 L27123 Y11998 AC007102 AC011214 AC011214 AF101055 J03247 M64656 AA417723 AA215428 Z95389 AA426336 M55426 AC004500 AB009078 U71200 F12685 AL021287

Drosophila melanogaster chromosome 3 clone BACR48E12 (D695) RPCI-9848.E.12map 87A-87B bacterial strain y; Cn bw sp, * *Check order * *, 86 non-sequential segments.Corynebacterium glutamicum aceA gene and thiX gene (part).Corynebacterium glutamicum isocitrate lyase (aceA) gene.The sequence 3 of United States Patent (USP) 5439822.Corynebacterium glutamicum (ATCC 13032) aceB gene.Corynebacterium glutamicum malate synthase (aceB) gene, complete cds.Pseudomonas fluorescens FC2.1, FC2.2, FC2.3c, FC2.4 and FC2.5c frame.Human chromosome 4 clone C0162P16map 4p16, complete sequence.The people clones 5_C_3, the low sequence of samples of passing through.The people clones 5_C_3, the low sequence of samples of passing through.Clostridium acetobutylicum atp operon, complete sequence.Rabbit phosphorylase kinase (alpha subunit) mRNA, complete cds.Oryctolagus cuniculus phosphorylase kinase alpha subunit mRNA, complete cds.Zv01b12.s1_NCI_CGAP_GCB1 people cDNA clones IMAGE:746207 3 ', is similar to contain the Alu repeat element; Contain element L1 repeat element; The mRNA sequence.Zr95a07.s1_NCI_CGAP_GCB1 people cDNA clones IMAGE:683412 3 ', is similar to contain the Alu repeat element; The mRNA sequence.Mycobacterium tuberculosis H37Rv complete genome group; Sections 146/162.Zv53g02.s1 Soares_ testis _ NHT people cDNA clones IMAGE:757394 3 ', mRNA sequence.Streptomyces fradiae glucosaminide acetyltransferase (aacC8) gene, complete cds.Human chromosome 5, P1 clones 1076B9 (LBNL H14), complete sequence.Brevibacterium saccharolyticum L-2, the gene of 3-butanediol dehydrogenation enzyme, complete cds.Bos taurus 3-oxobutanol reductase enzyme mRNA, complete cds.HSC3DA031 normalizing baby brain cDNA people cDNA clones c-3da03, mRNA sequence.Mycobacterium tuberculosis H37Rv complete genome group; Sections 132/162.

The unknown Corynebacterium glutamicum Corynebacterium glutamicum of Drosophila melanogaster Corynebacterium glutamicum Corynebacterium glutamicum Pseudomonas fluorescens, everybody clostridium acetobutylicum of (Pseudomonas fluorescens) people, (Clostridium acetobutylicum) Oryctolagus cuniculus Oryctolagus cuniculus people bacillus tuberculosis typus humanus people streptomyces fradiae, (Streptomyces fradiae) people's Brevibacterium saccharolyticum, (Brevibacteriun saccharolyticum) Bos taurus bacillus tuberculosis typus humanus

34,897 100,080 100,000 99,795 99,914 99,786 63,539 35,069 36,885 36,885 39,605 36,061 36,000 38,770 39,934 38,889 38,043 37,097 33,256 96,990 51,659 41,509 36,737

99-08-02 94-09-09 95-02-10 95-09-26 95-01-13 95-06-08 97-07-11 99-06-02 99-10-03 99-10-03 99-03-03 93-04-27 98-06-22 97-10-16 97-08-13 98-06-18 97-10-16 93-05-05 98-03-30 99-02-13 97-10-08 95-03-14 99-06-23

Table 4 (continuing)

Rxa02485 rxa02492 rxa02528 rxa02539 rxa02551 rxa02556 rxa02560

840 1,098 1,641 483 1,281 990

GB_BA1：SC6G10 GB_BA1：AP000060 GB_BA1：STMPGM GB_BA1：MTCY20G9 GB_BA1：U00018 GB_PR2：HS161N10 GB_HTG2：AC008235 GB_HTG2：AC008235 GB_BA2：RSU17129 GB_BA1：MTV038 GB_BA2：AF068264 GB_BA1：BACHYPTP GB_BA1：BACHUTWA PA GB_BA1：BSGBGLUC GB_HTG3：AC008128 GB_HTG3：AC008128 GB_PL2：AC005292 GB_IN1：CEF07A11 GB_EST32：AI731605 GB_IN1：CEF07A11

36,734 347,800 921 37,218 42,991 56,075 136,017 136,017 17,425 16,094 3,152 17,057 28,954 4,290 335,761 335,761 99,053 35,692 566 35692

AL049497 AP000060 M83661 Z77162 U00018 AL008707 AC008235 AC008235 U17129 AL021933 AF068264 D29985 D31856 Z34526 AC008128 AC008128 AC005292 Z66511 AI731605 Z66511

Streptomyces coelicolor clay 6G10.Aeropyrum pernix genome grinds DNA, 3/7 part.Streptomyces coelicolor phosphoglycerate phosphomutase (PGM) gene, complete cds.Mycobacterium tuberculosis H37Rv complete genome group; Sections 25/162.Mycobacterium leprae clay B2168.The human DNA sequence of the PAC 161N10 of chromosome x q25 is contained EST.Drosophila melanogaster chromosome 3 clone BACR15B19 (D995) RPCI-98 15.B.19map 94F-95A bacterial strain y; Cn bw sp, * *Check order * *, 125 non-sequential segments.Drosophila melanogaster chromosome 3 clone BACR15B19 (D995) RPCI-98 15.B.19map 94F-95A bacterial strain y; Cn bw sp, * *Check order * *, 125 non-sequential segments.Rhodococcus TheA (theA) gene, complete cds; And unknown gene.Mycobacterium tuberculosis H37Rv complete genome group; Sections 24/162.Pseudomonas aeruginosa quinoprotein ethanol dehydrogenase (exaA) gene, part cds; Cytochrome c 550 precursors (exaB), NAD+ dependency acetaldehyde dehydrogenase (exaC) and Pyrroloquinoline quinone synthesize A (pqqA) gene, complete cds; And synthetic B (pqqB) gene of Pyrroloquinoline quinone, part cds.The subtilis wall is conjugated protein and infer proteic wapA and orf gene.The subtilis genome that contains hut and wapA locus.The gene of subtilis (Marburg 168) β-glucoside permease and beta-glucosidase enzyme.The people, * *Check order * *, 106 non-sequential segments.The people, * *Check order * *, 106 non-sequential segments.The genome sequence of Arabidopis thaliana BACF26F24, complete sequence.Caenorhabditis elegans clay F07A11, complete sequence.BNLGHi102016 days cotton fiber upland cotton cDNA 5 ' are similar to (AC004684) putative protein [Arabidopis thaliana], the mRNA sequence.Caenorhabditis elegans clay F07A11, complete sequence.

Everybody Arabidopis thaliana Caenorhabditis elegans upland cotton Caenorhabditis elegans of streptomyces coelicolor Aeropyrum pernix streptomyces coelicolor mycobacterium tuberculosis Mycobacterium leprae people's drosophila melanogaster drosophila melanogaster Rhodococcus (Rhodococcus erythropolis) mycobacterium tuberculosis Pseudomonas aeruginosa subtilis subtilis subtilis

35,511 48,014 65,672 61,436 37,893 37,051 36,822 36,822 66,117 65,174 65,448 53,602 53,602 53,602 34,022 34,022 33,858 36,420 38,095 33,707

99-03-24 99-06-22 93-04-26 98-06-17 94-03-01 99-11-23 99-08-02 99-08-02 99-07-16 98-06-17 99-03-18 99-02-07 99-02-07 95-07-03 99-08-22 99-08-22 99-04-16 99-09-02 99-06-11 99-09-02

Table 4 (continuing)

Rxa02572 rxa02596 rxa02611 rxa02612 rxa02621 rxa02640 rxa02654 rxa02666

668 1,326 1,775 2,316 942 1,650 1,008 891

GB_BA1：MTCY63 GB_BA1：MTCY63 GB_HTG1：HS24H01 GB_BA1：MTV026 GB_BA2：AF026540 GB_BA2：MTU96128 GB_BA1：MTCY130 GB_BA1：MSGY151 GB_BA1：U00014 GB_BA1：MTCY130 GB_BA1：MSGY151 GB_BA1：STMGLGEN GB_BA1：CGL133719 GB_IN1：CEM106 GB_EST29：AI547662 GB_BA1：MTV025 GB_BA1：PAU49666 GB_BA1：AB015974 GB_EST6：N65787 GB_PL2：T17H3 GB_RO：MMU58105 GB_PR3：AC004643

38,900 38,900 46,989 23,740 1,778 1,200 32,514 37,036 36,470 32,514 37,036 2,557 1,839 39,973 377 121,125 4,495 1,641 512 65,839 88,871 43411

Z96800 Z96800 AL121632 AL022076 AF026540 U96128 Z73902 AD000018 U00014 Z73902 AD000018 L11647 AL133719 Z46935 AI547662 AL022121 U49666 AB015974 N65787 AC005916 U58105 AC004643

Mycobacterium tuberculosis H37Rv complete genome group; Sections 16/162.Mycobacterium tuberculosis H37Rv complete genome group; Sections 16/162.Human chromosome 21 clone LLNLc1 16H0124map 21q21, * *Check order * *, non-sequential segments.Mycobacterium tuberculosis H37Rv complete genome group; Sections 157/162.Mycobacterium tuberculosis UDP-galactopyranose mutase (glf) gene, complete cds.Mycobacterium tuberculosis UDP-galactopyranose mutase (glf) gene, complete cds.Mycobacterium tuberculosis H37Rv complete genome group; Sections 59/162.The sequence of mycobacterium tuberculosis clone y151.Mycobacterium leprae clay B1549.Mycobacterium tuberculosis H37Rv complete genome group; Sections 59/162.The sequence of mycobacterium tuberculosis clone y151.Streptomyces aureofaciens glycogen branching enzyme (glgB) gene, complete cds.Corynebacterium glutamicum yjcc gene, antR gene and citE gene, part.Caenorhabditis elegans clay M106, complete sequence.UI-R-C3-sz-h-03-0-UI.s1 UI-R-C3 brown rat cDNA clone UI-R-C3-sz-h-03-0-UI 3 ', the mRNA sequence.Mycobacterium tuberculosis H37Rv complete genome group; Sections 155/162.Pseudomonas aeruginosa (orfX), glycerine disperse promote albumen (glpF), glycerol kinase (glpK) and Glp repressor (glpR) gene, complete cds and (orfK) gene, part cds.The glpK gene of holder Laplace pseudomonas glycerol kinase, complete cds.20827 λ-PRL2 Arabidopis thaliana cDNA clones 232B7T7, mRNA sequence.Arabidopsis thaliana chromosome 1BACT17H3 sequence, complete sequence.House mouse Btk locus, α-D-Ban Rutangganmei (Ags), ribosomal protein (L44L) and Bruton Tyrosylprotein kinase (Btk) gene, complete cds.Human chromosome 16, clay clone 363E3 (LANL), complete sequence.

Mycobacterium tuberculosis mycobacterium tuberculosis bacillus tuberculosis typus humanus mycobacterium tuberculosis mycobacterium tuberculosis mycobacterium tuberculosis mycobacterium tuberculosis Mycobacterium leprae mycobacterium tuberculosis mycobacterium tuberculosis streptomyces aureofaciens, (Streptomyces aureofaciens) Corynebacterium glutamicum Caenorhabditis elegans brown rat mycobacterium tuberculosis Pseudomonas aeruginosa holder Laplace pseudomonas, (Pseudomonas tolaasil) Arabidopis thaliana Arabidopis thaliana house mouse people

61,677 37,170 19,820 36,957 67,627 70,417 38,532 60,575 57,486 38,018 58,510 57,193 36,858 37,608 50,667 39,187 59,273 58,339 39,637 33,735 35,431 38,851

98-06-17 98-06-17 99-09-29 99-06-24 98-10-30 98-03-25 98-06-17 96-12-10 94-09-29 98-06-17 96-12-10 95-05-25 99-08-12 99-09-02 99-07-03 99-06-24 97-05-18 99-08-28 98-01-05 99-08-05 97-02-13 98-05-01

Table 4 (continuing)

Rxa02675 rxa02694 rxa02729 rxa02730 rxa02737 rxa02738 rxa02739

1,980 1,065 844 1,161 1,665 1,203 2223

GB_PR3：AC004643 GB_BA2：AF049897 GB_BA1：PDENQOUR F GB_BA1：MTCY339 GB_BA1：MXADEVRS GB_BA1：BACLDH GB_BA1：BACLDHL GB_PAT：A06664 GB_EST15：AA494626 GB_EST15：AA494626 GB_EST19：AA758660 GB_EST15：AA494626 GB_pR4：AC006285 GB_PAT：E13655 GB_BA1：MTCY493 GB_BA1：SC5A7 GB_PAT：E13655 GB_BA1：SCC22 GB_BA1：SC5A7 GB_BA1：AB023377

43,411 9,196 10,425 42,861 2,452 1,147 1,361 1,350 121 121 233 121 150,172 2,260 40,790 40,337 2,260 22,115 40,337 2572

AC004643 AF049897 L02354 Z77163 L19029 M19394 M14788 AO6664 AA494626 AA494626 AA758660 AA494626 AC006285 E13655 Z95844 AL031107 E13655 AL096839 AL031107 AB023377

Human chromosome 16, clay clone 363E3 (LANL), complete sequence.Corynebacterium glutamicum N-acetyl glutamy phosphoric acid reduction enzyme (argC), ornithine acetyltransferase (argJ), N-acetylglutamat kinases (argB), acetyl-ornithine transaminase (argD), ornithine carbamyl based transferase (argF), arginine repressor (argR), argininosuccinic acid synthase (argG) and argininosuccinic acid lyase (argH) gene, complete cds.Paracoccus denitrificans nadh dehydrogenase (URF4), (NQO8), (NQO9), (URF5), (URF6), (NQO10), (NQO11), (NQO12), (NQO13) and (NQO14) gene, complete cds; Vitamin H [acetyl-CoA carboxyl] ligase enzyme (birA) gene, complete cds.Mycobacterium tuberculosis H37Rv complete genome group; Sections 101/162.Yellow myxococcus devR and devS gene, complete cds.Thermosol genus bacillus serum lactic dehydrogenase (LDH) gene, complete cds.The lct gene of bacstearothermophilus coding L-serum lactic dehydrogenase, complete cds.Bacstearothermophilus lct gene.Fa09d04.r1 Zebrafish ICRFzfls Danio rerio cDNA clones 11,A22 5 ', and it is conjugated protein to be similar to TR:G1171163 G1171163 G/T mispairing; The mRNA sequence.Fa09d04.r1 Zebrafish ICRFzfls Danio rerio cDNA clones 11,A22 5 ', and it is conjugated protein to be similar to TR:G1171163 G1171163 G/T mispairing; The mRNA sequence.Ah67d06.s1 Soares_ testis _ NHT people cDNA clones 1,320,683 3 ', the mRNA sequence.Fa09d04.r1 Zebrafish ICRFzfls Danio rerio cDNA clones 11,A22 5 ', and it is conjugated protein to be similar to the TR:G1171163G1171163G/T mispairing; The mRNA sequence.The people, complete sequence.The gDNA of coding glucose-6-phosphate dehydrogenase (G6PD).Mycobacterium tuberculosis H37Rv complete genome group; Sections 63/162.Streptomyces coelicolor clay 5A7.The gDNA of coding glucose-6-phosphate dehydrogenase (G6PD).Streptomyces coelicolor clay C22.Streptomyces coelicolor clay 5A7.Corynebacterium glutamicum transketolase tkt gene, complete cds.

Human glutamic acid rod bacillus Paracoccus denitrificans, the yellow myxococcus of (Paracoccus denitrificans) mycobacterium tuberculosis, (Myxococcus xanthus) thermosol genus bacillus, (Bacillus caldolyticus) bacstearothermophilus bacstearothermophilus Danio rerio Danio rerio people Danio rerio human glutamic acid rod bacillus mycobacterium tuberculosis streptomyces coelicolor Corynebacterium glutamicum streptomyces coelicolor streptomyces coelicolor Corynebacterium glutamicum

41,599 40,413 40,735 36,471 38,477 57,371 57,277 57,277 50,746 36,364 37,059 42,149 37,655 99,580 38,363 39,444 98,226 60,399 36,426 99,640

98-05-01 98-07-01 93-05-20 98-06-17 94-01-27 93-04-26 93-04-26 93-07-29 97-06-27 97-06-27 98-12-29 97-06-27 99-11-15 98-06-24 98-06-19 98-07-27 98-06-24 99-07-12 98-07-27 99-02-20

Table 4 (continuing)

Rxa02740 rxa02741 rxa02743 rxa02797 rxa02803 rxa02821

1,053 1,089 1,161 1,026 680 363

GB_BA1：MLCL536 GB_BA1：U00013 GB_HTG2：AC006247 GB_HTG2：AC006247 GB_HTG3：AC007150 GB_HTG2：AC004951 GB_HTG2：AC004951 GB_IN1：AB006546 GB_BA1：MLCL536 GB_BA1：U00013 GB_HTG2：AC007401 GB_BA1：CGBETPGE N GB_GSS9：AQ148714 GB_BA1：BFU64514 GB_BA1：U00020 GB_BA2：PSU85643 GB_BA1：SC6G4 GB_HTG2：AC008105 GB_HTG2：AC008105 GB_EST33：AV117143

36,224 35,881 174,368 174,368 121,474 129,429 129,429 931 36,224 35,881 83,657 2,339 405 3,837 36,947 4,032 41,055 91,421 91,421 222

Z99125 U00013 AC006247 AC006247 AC007150 AC004951 AC004951 AB006546 Z99125 U00013 AC007401 X93514 AQ148714 U64514 U00020 U85643 AL031317 AC008105 AC008105 AV117143

Mycobacterium leprae clay L536.Mycobacterium leprae clay B1496.Drosophila melanogaster chromosome 2 clone BACR48I10 (D505) RPCI-98 48.1.10map 49E6-49F8 bacterial strain y; Cn bw sp, * *Check order * *, 17 non-sequential segments.Drosophila melanogaster chromosome 2 clone BACR48I10 (D505) RPCI-98 48.1.10map 49E6-49F8 bacterial strain y; Cn bw sp, * *Check order * *, 17 non-sequential segments.Drosophila melanogaster chromosome 2 clone BACR16P13 (D597) RPCI-9816.P.13map 49E-49F bacterial strain y; Cn bw sp, * *Check order * *, 87 non-sequential segments.The people clones DJ1022I14, * *Check order * *, 14 non-sequential segments.The people clones DJ1022I14, * *Check order * *, 14 non-sequential segments.The mRNA of Ephydatia fluviatilis G albumen a subunit 4, part cds.Mycobacterium leprae clay L536.Mycobacterium leprae clay B1496.The people clones NH0501O07, * *Check order * *, 3 non-sequential segments.Corynebacterium glutamicum betP gene.People's gene group sperm library D people's gene group clone flat board=3136 row=5 row=A of HS_3136_A1_A03_MR CIT approval, genome summary sequence.Bacillus firmus dppABC operon, two peptide transport protein dppA genes, part cds and two peptide transport protein dooB and dppC gene, complete cds.The dihydrofolate synthase gene is inferred in the pathogenic mutation of Mycobacterium leprae clay B229 pseudomonas syringae cloves, part cds, regulate albumen MrsA (mrsA), triose-phosphate isomerase (tpiA), translocator SecG (secG), tRNA-Leu, tRN A-Met and 15kDa protein gene, complete cds.Streptomyces coelicolor clay 6G4.Human chromosome 17 clone 2020_K_17map 17, * *Check order * *, 12 non-sequential segments.Human chromosome 17 clone 2020_K_17map 17, * *Check order * *, 12 non-sequential segments.10 days embryo house mouses of AV117143 house mouse C57BL/6J cDNA clones 26102O0J17, mRNA sequence.

Everybody Ephydatia fluviatilis Mycobacterium leprae Mycobacterium leprae human glutamic acid of Mycobacterium leprae Mycobacterium leprae drosophila melanogaster drosophila melanogaster drosophila melanogaster rod bacillus people's bacillus firmus (Bacillus firmus) Mycobacterium leprae pseudomonas syringae cloves everybody house mouse of mutation (Pseudomonas syringae pv.syringae) streptomyces coelicolor of causing a disease

61,573 61,573 37,105 37,105 38,728 33,116 33,116 36,379 48,401 48,401 37,128 38,889 34,321 38,072 34,462 50,445 59,314 37,607 37,607 40,157

98-12-04 94-03-01 99-08-02 99-08-02 99-09-20 98-06-12 98-06-12 99-06-23 98-12-04 94-03-01 99-06-26 97-09-08 98-10-08 97-02-01 94-03-01 97-04-09 98-08-20 99-07-22 99-07-22 99-06-30

Table 4 (continuing)

Rxa02829 rxa03216 rxa03215 rxa03224

373 1,141 1,038 1288

GB_HTG1:HSU9G8 GB_HTG1:HSU9G8 GB_PR3:HSU85B5 GB_HTG3:AC008184 GB_EST15:AA477537 GB_EST26:A1330662 GB_BA1:SC3F9 GB_BA1:SLLINC GB_HTG5:AC009660 GB_PR3:AC004076 GB_PL2:SPAC926 GB_BA2:AE001081

48,735 48,735 39,550 151,720 411 412 19,830 36,270 204,320 41,322 23,193 11473

AL008714 AL008714 Z69724 AC008184 AA477537 A1330662 AL023862 X79146 AC009660 AC004076 AL110469 AE001081

Human chromosome X clones LL0XNC01-9G8, * *Check order * *, non-sequential segments.Human chromosome X clones LL0XNC01-9G8, * *Check order * *, non-sequential segments.The human DNA sequence of clay U85B5 is between chromosome x mark DXS366 and the DXS87.Drosophila melanogaster chromosome 2 clone BACR04D05 (D540) RPCI-98 04.D.5map 36E5-36F2 bacterial strain y; Cn bw sp, * *Check order * *, 27 non-sequential segments.Zu36g 12.r1 Soares ovarian tumor NbHOT people cDNA clones IMAGE:740134 5 ', is similar to and contains the Alu repeat element; Contain element HGR repeat element; The mRNA sequence.Fa91d08.y1 zebrafish fin regeneration in 1 day Danio rerio cDNA 5 ', the mRNA sequence.Streptomyces coelicolor clay 3F9.Streptomyces lincolnensis (78-11) lincomycin produces gene.Human chromosome 15 clone RP11-424J10map 15, * *Check order * *, 41 non-sequential segments.Human chromosome 19, clay R30217, complete sequence.Chestnut wine fission yeast karyomit(e) 1 clay c926.Archaeoglobus fulgidus complete genome group 26/172 part.

Everybody trembles wine fission yeast (Schizosaccharomyces pombe) Archaeoglobus fulgidus everybody drosophila melanogaster people Danio rerio streptomyces coelicolor A3 (2) streptomyces lincolnensis (Streptomyces lincolnensis) of people

41,595 41,595 41,595 39,600 37,260 37,805 48,657 39,430 35,151 37,788 38,474 35,871

99-11-23 99-11-23 99-11-23 99-08-02 97-11-09 98-12-28 99-02-10 96-05-15 99-12-04 98-01-29 99-09-02 97-12-15

The embodiment part

Embodiment 1: the preparation of the total genomic dna of Corynebacterium glutamicum ATCC13032

Allow Corynebacterium glutamicum (ATCC 13032) culture under 30 ℃ in BHI substratum (Difco) oscillating growth spend the night.By centrifugal collecting cell, abandoning supernatant is resuspended in 5ml damping fluid I (all specified volume bacterium of the 5%--of culture initial volume are all calculated according to the 100ml culture volume) with cell.The composition of damping fluid I: 140.34g/l sucrose, 2.46g/l ×7 、10ml/l? (100g/l uses solution Transfer to pH6.7), 50ml/l M12 enriched material (10g/l 、1g/l? 、2g/l? ×7 、0.2g/l? , 0.5g/l yeast extract paste (Difco), 10ml/l trace element mixture (200mg/l × 、10mg/l? ×7 、3mg/l? ×4 、30mg/l 、20mg/l? ×6 、1mg/l? ×6 、3mg/l? ×2 , 500mg/l complexing agent (EDTA or citric acid), 100mg/l vitamine mixture (0.2mg/l vitamin H, 0.2mg/l folic acid, 20mg/l para-amino benzoic acid, 20mg/l riboflavin, 40mg/l calcium pantothenate (ca-panthothenate), 140mg/l nicotinic acid, 40mg/l pyridoxal hydrochloride, 200mg/l inositol).N,O-Diacetylmuramidase is added in the supernatant liquor to final concentration 2.5mg/ml.After about 4 hours, cell walls is degraded, by the protoplastis that centrifugal results produced in 37 ℃ of incubations.Precipitation is with 5ml damping fluid I washing 1 time, with 5ml TE damping fluid (10mM Tris- , 1mMEDTA, pH8) washing 1 time.Precipitation is resuspended in the 4ml TE damping fluid, adds 0.5mlSDS solution (10%) and 0.5ml Solution (5M).Adding Proteinase K to final concentration 200 μ g/ml, the night that will suspend was in about 18 hours of 37 ℃ of incubations.Adopt standard method, by using phenol, phenol-chloroform-primary isoamyl alcohol and chloroform-primary isoamyl alcohol extracting, purify DNA.Then, by 3M sodium acetate and 2 volume ethanol that add 1/50 volume, then in-20 ℃ of incubations 30 minutes, in supercentrifuge with SS34 rotor (Sorvall) with 12, centrifugal 30 minutes of 000rpm precipitates described DNA.DNA is dissolved in the TE damping fluid that 1ml contains 20 μ g/ml RNA enzyme A, in 4 ℃ to 1000ml TE damping fluid dialysis at least 3 hours.During this period, exchange buffering liquid is 3 times.In the dna solution through dialysing of 0.4ml equal portions, add 0.4ml 2M With 0.8ml ethanol.After 30 minutes, collect DNA in-20 ℃ of incubations by centrifugal (13,000rpm, Biofuge Fresco, Heraeus, Hanau, Germany).The DNA precipitation is dissolved in the TE damping fluid.DNA with this method preparation can be used for all purposes, comprises the structure of southern blotting technique analysis or genomic library.

Embodiment 2: make up the genomic library of Corynebacterium glutamicum ATCC13032 in intestinal bacteria

Adopt the DNA of embodiment 1 described preparation, according to known clear and definite method (referring to for example Sambrook, J. etc., (1989) " Molecular Cloning:A Laboratory Manual ", ColdSpring Harbor Laboratory Press, or Ausubel, F.M. etc. (1994) " CurrentProtocols in Molecular Biology ", John Wiley ﹠amp; Sons.) make up cosmid library and plasmid library.

Can use any plasmid or clay.The concrete plasmid that uses be plasmid pBR322 (Sutcliffe, J.G. (1979) Proc.Natl.Acad Sci.USA, 75:3737-3741), pACYC177 (Change ﹠amp; Cohen (1978) J.Bacteriol 134:1141-1156), pBS plasmid series (pBSSK+, pBSSK-etc.; Stratagene, LaJolla, USA) or clay such as SuperCos1 (Stratagene, LaJolla, USA) or Lorist6 (Gibson, T.J., RosenthalA. and Waterson, R.H. (1987) Gene 53:283-286).Use plasmid pSL109 can make up the gene library (Lee, H.-S. and A.J.Sinskey (1994) J.Microbiol.Biotechnol.4:256-263) that is used in particular for Corynebacterium glutamicum.

Embodiment 3:DNA order-checking and computing function analysis

The genomic library that Application Example 2 is described is according to standard method, especially utilize the chain termination method of ABI377 sequenator (referring to for example Fleischman, R.D. etc. (1995) " genome sequencing at random and assembling of hemophilus influenzae Rd. ", Science 269:496-512) carries out dna sequencing.Use has the sequencing primer of following nucleotide sequence: 5 '-GGAAACAGTATGACCATG-3 ' (SEQ ID NO:783) or 5 '-GTAAAACGACGGCCAGT-3 ' (SEQ ID N0:784).

Embodiment 4: mutagenesis in vivo

Plasmid (or other carrier) DNA is gone down to posterity by impaired intestinal bacteria or other biology (for example Bacillaceae bacillus or yeast such as yeast saccharomyces cerevisiae) of ability that keeps the genetic information integrity, thus mutagenesis Corynebacterium glutamicum in vivo.The DNA repair system gene of typical case's mutator exists sudden change (for example muHLS, mutD, mutT etc.; Reference is seen Rupp, and W.D. (1996) DNA repair mechanism is stated from: Escherichia coli and Salmonella, and the 2277-2294 page or leaf, ASM:Washington.).This class bacterial strain is that those skilled in the art are known.Greener for example, A. and Callahan have introduced the use of described bacterial strain among M. (1994) Strategies_7:32-34.

Embodiment 5: the DNA between intestinal bacteria and the Corynebacterium glutamicum shifts

Some Corynebacteriums and brevibacterium sp species contain self-replicating (summarizes referring to for example Martin J.F. etc. (1987) Biotechnology, endogenous plasmid 5:137-146) (for example pHM1519 or pBL1).Adopt the intestinal bacteria standard vector (Sambrook that wherein adds Corynebacterium glutamicum replication orgin and Corynebacterium glutamicum appropriate flags, J. etc. (1989), " MolecularCloning:A Laboratory Manual ", Cold Spring Harbor Laboratory Press or Ausubel, F.M. etc. (1994) " Current Protocols in Molecular Biology ", JohnWiley ﹠amp; Sons), can easily make up the shuttle vectors of intestinal bacteria and Corynebacterium glutamicum.Described replication orgin is preferably taken from the endogenous plasmid of separation from Corynebacterium and brevibacterium sp species.The transformation marker of concrete these species that use is kalamycin resistance gene (for example kalamycin resistance gene of Tn5 or Tn903 transposon generation) or chloramphenicol resistance gene (Winnacker, E.L. (1987), From Genes to Clones-Introduction to GeneTechnology, VCH, Weinheim).Enumerated a large amount of in the described document about making up the example of various shuttle vectorss, described shuttle vectors can duplicate and can be used for some purposes in intestinal bacteria and Corynebacterium glutamicum, (reference is referring to for example Yoshihama to comprise gene overexpression, (1985) J.Bacteriol.162:591-597 such as M., (1987) Biotechnology such as Martin J.F., 5:137-146 and Eikmanns, B.J. etc. (1991) Gene, 102:93-98).

The application standard method can be cloned into goal gene a kind of above-mentioned shuttle vectors and this heterozygosis carrier is imported in the Corynebacterium glutamicum strain.Can adopt following method to transform Corynebacterium glutamicum: protoplast transformation (Kastsumata, (1984) J.Bacteriol.159306-311 such as R.), electroporation (Liebl, (1989) FEMS Microbiol.Letters such as E., 53:399-303), if use special carrier, also can adopt method of joining (seeing for example Sch_fer, A etc. (1990) J.Bacteriol.172:1663-1666).Be transformed into intestinal bacteria by preparation Corynebacterium glutamicum plasmid DNA (utilizing the known standard method in this area) and with it, also can make shuttle vectors transfer to intestinal bacteria from Corynebacterium glutamicum.Adopt standard method can carry out this step, but preferably use Mcr defective coli strain such as NM522 (Gough ﹠amp; Murray (1983) J.Mol.Biol.166:1-19).

Can use and comprise pCGl (U.S. Patent number 4,617,267) or its fragment and the optional TN903 kalamycin resistance gene (Grindley that comprises, N.D. and Joyce, C.M. (1980) Proc.Natl.Acad.Sci.USA 77 (12): plasmid 7176-7180) is the overexpression range gene in Corynebacterium glutamicum strain.In addition, also can use plasmid pSL109 overexpression range gene (Lee, H.-S. and A.J.Sinskey (1994) J.Microbiol.Biotechnol.4:256-263) in Corynebacterium glutamicum strain.

Except using the rf plasmid, also can realize gene overexpression by being integrated into genome.Utilize known method can be implemented in genome conformity in Corynebacterium glutamicum or other Corynebacterium or the brevibacterium sp species, for example with the fusion (REMI) (referring to for example DE patent 19823834) of the homologous recombination in genome district, restriction endonuclease mediation or use transposon.The activity that also can take following measure to modify regulatory region (for example promotor, repressor and/or enhanser) and regulate goal gene: utilize fix-point method (for example homologous recombination) or carry out sequence modification, insertion or disappearance based on the method (for example transposon mutagenesis or REMI) of random occurrence.Also can insert the nucleotide sequence of transcription terminator effect at 3 ' of the one or more gene coding regions of the present invention; Described terminator is that this area is known, for example at Winnacker, E.L. (1987) FromGenes to Clones-Introduction to Gene Technology.VCH:Weinheim) in its introduction is arranged.

Embodiment 6: estimate the expression of mutain

Mutain activity in the observation transformed host cell depends on such fact: mutain reaches with similar scale in the mode similar to wild-type protein.The process useful of a kind of definite mutator gene transcriptional level (can translate into the index of the mRNA amount of gene product) is to carry out the RNA trace (reference is for example seen (1988) Current Protocols in MolecularBiology such as Ausubel, Wiley: New York), wherein use the design primer of detectable label (being generally radioactivity or chemoluminescence) mark binding purposes gene, make as the total RNA that extracts described organism culture, electrophoresis on gel, be transferred on the stabilized matrix and during with described probe incubation, the combination of described probe and binding capacity can illustrate the mRNA amount that has described gene and indicate this gene.Such information is the evidence that mutator gene is transcribed degree.Using the known method in some this areas can prepare total cell RNA from Corynebacterium glutamicum, Bormann for example, the method that E.R. etc. (1992) Mol.Microbiol.6:317-326 introduces.

Whether exist or relative quantity in order to estimate described mRNA translation albumen, can use standard technique for example western blotting (referring to (1988) Current Protocols inMolecular Biology such as for example Ausubel, Wiley: New York).In this process, extract total cell protein, separate through gel electrophoresis, be transferred to as combining proteic probe of needs such as antibody incubation on the matrix of nitrocellulose and with specificity.This probe is general with the chemoluminescence or the colorimetric marker mark that detect easily.Observe marker existence and marker amount mutain and the amount thereof that existence needs in the described cell is described.

Embodiment 7: cultivation-substratum of the Corynebacterium glutamicum of genetic improvement and culture condition

With synthetic or spontaneous growth culture medium culturing genetic improvement rod bacillus.The many different growth mediums that are used for excellent bacillus are well-known and easy acquisition (Lieb etc. (1989) Appl.Microbiol.Biotechnol., 32:205-210; (1998) Biotechnology Letters such as von der Osten, 11:11-16; Patent DE 4,120, and 867; Liebl (1992) " Corynebacterium " is stated from: The Procaryotes, and the II volume, Balows, A. etc. write, Springer-Verlag).The composition of these substratum is: one or more carbon sources, nitrogenous source, inorganic salt, VITAMIN and trace element.Preferred carbon source is that sugar is as monose, disaccharides or polysaccharide.For example glucose, fructose, seminose, semi-lactosi, ribose, sorbose, ribulose, lactose, maltose, sucrose, raffinose, starch or Mierocrystalline cellulose are extraordinary carbon sources.Also can provide sugar for substratum by other byproduct of complex chemical compound such as molasses or refined sugar.The mixture that different carbon sources are provided also may be useful.Other possible carbon source is alcohols and organic acid, for example methyl alcohol, ethanol, acetic acid or lactic acid.Nitrogenous source is generally the organic or inorganic nitrogen compound, perhaps contains the material of these compounds.Typical case's nitrogenous source comprises ammonia or ammonium salt, for example ammonium chloride or ammonium sulfate, ammonium hydroxide, nitrate, urea, amino acid or compound nitrogen source such as corn steep liquor, soyflour, soybean protein, yeast extract, meat extract etc.

The inorganic salt compound that substratum can contain comprises hydrochloride, phosphoric acid salt or the vitriol of calcium, magnesium, sodium, cobalt, molybdenum, potassium, manganese, zinc, copper and iron.Can add chelate compound in the described substratum, to keep the solution metal ion.Especially effectively chelate compound comprises dihydric phenol (for example catechol or catechol hydrochlorate) or organic acid (for example citric acid).Described substratum also routine contains other somatomedin, for example VITAMIN or growth stimulant, and the example comprises vitamin H, riboflavin, VitB1, folic acid, nicotinic acid, pantothenic acid and pyridoxol.Somatomedin and salt are derived from the complex medium component usually, for example yeast extract, molasses, corn steep liquor etc.The substratum mixture is cut into branch really and direct experiment is closely related and specifically depend on each particular case.Can be about the information of medium optimization at textbook " Applied Microbiol.Physiology; obtain among the APractical Approach (P.M.Rhodes, P.F.Stanbury writes, IRL Press (1997); 53-73 page or leaf, ISBN 0 19 9635773).Also can be from commercial Supplier Selection growth medium, for example standard No. 1 (Merck) or BHI (grain heart infusion, DIFCO) etc.

All nutrient media componentses are by heating (in 1.5 handkerchiefs and 121 ℃ 20 minutes) or sterile filtration sterilization.Described component can be sterilized together, can sterilize respectively if desired.Just exist when all nutrient media componentses can be cultivated beginning, perhaps can choose wantonly continuously or adding in batches.

Each experiment separate provision culture condition.Temperature should be 15 ℃-45 ℃.Culture temperature can keep constant or experiment in change.The pH of substratum should be 5-8.5, preferred about 7.0, can add buffer reagent in substratum and keep pH.The typical buffer that is used for this purpose is a potassium phosphate buffer agent.Can select to use or use simultaneously synthetic buffer reagent such as MOPS, HEPES, ACES etc.Also can add sodium hydroxide or ammonium hydroxide in the training period and keep constant cultivation pH.If use complex medium component such as yeast extract, may reduce the needs of extra buffer reagent, because in fact many complex chemical compounds have high surge capability.If use the described microorganism of fermentor cultivation, also can use ammonia control pH.

Incubation time is generally a few hours to a couple of days.Select incubation time so that liquid nutrient medium cumulative product amount is maximum.Available various container carries out disclosed use, for example the glass or the metal fermentor tank of microtiter plate, Glass tubing, vial or different sizes.In order to screen a large amount of clones, use microtiter plate, Glass tubing or shake bottle (have or do not have baffle plate).The preferred 100ml that uses shakes bottle, wherein adorns the growth medium that needs with 10% (volume).Culturing bottle should be gone up with the jolting of 100-300rpm velocity range at shaking table (amplitude 25mm).Keeping moistening atmosphere makes the evaporation forfeiture minimum; Perhaps should accurately proofread and correct vaporization losses.

If test heredity improvement clone also should test the contrast clone of not improvement or contain without any the contrast of inserting segmental basic plasmid and clone.Utilize in the agar plate of 30 ℃ of incubations such as the cell inoculation substratum on the CM flat board (10g/l glucose, 2.5g/l sodium-chlor, 2g/l urea, the poly-peptone of 10g/l, 5g/l yeast extract, 5g/l meat extract, 22g/l sodium-chlor, 2g/l urea, the poly-peptone of 10g/l, 5g/l yeast extract, 5g/l meat extract, 22g/l agar transfer to pH6.8 with 2M sodium hydroxide) to OD ₆₀₀Be 0.5-1.5.Add the salt aqeous suspension of the Corynebacterium glutamicum cell derive from the CM flat board or add the pre-culture of liquid of this bacterium, thereby finish culture medium inoculated.

Embodiment 8: the function of analyzed in vitro mutain

This area has clear and definite enzymic activity and kinetic parameter assay method.The ratio that must make the experiment of measuring any given change enzymic activity be fit to wild-type enzyme is lived, and this is fully in persons skilled in the art limit of power.Be found in for example following document: Dixon, M. and Webb, E.C., (1979) Enzymes, Longmans:London about the general introduction of enzyme and the detail and the many enzyme assay examples that relate to structure, kinetics, principle, method, application; Fersht, (1985) Enzyme Structure and Mechanism, Freeman: New York; Walsh, (1979) Enzymatic Reaction Mechanisms.Freeman:San Francisco; Price, N.C., Stevens, L. (1982) Fundamentals of Enzymology.Oxford Univ.Press:Oxford; Boyer, P.D. write (1983) The Enzymes, the third edition, Academic Press: New York; Bisswanger, H., (1994) Enzymkinetik, second edition, VCH:Weinheim (ISBN 3527300325); Bergmeyer, H.U., Bergmeyer, J., Gra β 1, M. write (1983-1986) Methods of Enzymatic Analysis, the third edition, I-XII volume, VerlagChemie:Weinheim; And Ullmann ' s Encyclopedia of Industrial Chemistry (1987), A9 volume, " Enzymes ", VCH:Weinheim, 352-363 page or leaf.

Can use the displacement of several clear and definite methods such as DNA band and measure the protein-active of (being also referred to as gel blocking measures) mensuration in conjunction with DNA.Available reporter gene is measured (Kolmar for example, H. etc. (1995) EMBO J.14:3895-3904 and the mensuration introduced of citing document wherein) and is measured the influence of described albumen to other developed by molecule.The reporter gene test macro is well-known and clearly is used for prokaryote and eukaryotic cells, utilizes enzyme such as beta galactosidase enzyme, green fluorescent protein etc.

According to for example Gennis, R.B. (1989) " hole, passage and translocator ", be stated from: Biomembranes, Molecular Structure and Function, Springer:Heidelberg, the method that 85-137,199-234 and 270-322 page or leaf are introduced can be measured the activity of protein called membrane transporters.

Embodiment 9: analyze the influence of mutain to needing product to produce

The heredity that can followingly detect Corynebacterium glutamicum improves needing the influence of compound (for example amino acid) generation: the improvement microorganism is grown down at conditions suitable (for example above-mentioned condition), and the output of analyzing then in described substratum and/or the cellular component that needs product (being amino acid) increases situation.Described analytical technology is that persons skilled in the art are known, comprise that spectrum detection method, thin-layer chromatography, various staining, enzyme and micro-biological process and analytical chromatography method such as high performance liquid chromatography are (referring to for example Ullman, Encyclopedia of Industrial Chemistry, the A2 volume, 89-90 and 443-613 page or leaf, VCH:Weinheim (1985); Fallon, A. etc., (1987) " HPLC application in biological chemistry " is stated from: Laboratory Techniquesin Biochemistry and Molecular Biology, the 17th volume; Rehm etc. (1993) Biotechnology, the 3rd volume, III chapter: " recovery of product and purifying ", 469-714 page or leaf, VCH:Weinheim; Belter, P.A. etc. (1988) Bioseparations:downstreamprocessing for biotechnology, John Wiley and Sons; Kennedy, J.F. and Cabral, J.M.S. (1992) Recovery processes for biological materials, John Wiley and Sons; Shaeiwitz, J.A. and Henry, J.D. (1988) biological chemistry is separated, and is stated from: Ulmann ' s Encyclopedia of Industrial Chemistry, B3 volume, Chapter 11,1-27 page or leaf, VCH:Weinheim; And Dechow, F.J. (1989) Separation andpurification techniques in biotechnology, Noyes Publications).

Except detecting the fermentation end product, also can analyze other component that needs the pathways metabolism of product in order to generation, for example intermediate and by product are to determine to produce the overall efficiency of described compound.Analytical procedure comprises the gas that produces between nutrient substance level (for example sugar, hydro carbons, nitrogenous source, phosphoric acid salt and other ion), detection of biological amount composition and the growth of measuring in the substratum, the output of analyzing biosynthetic pathway common metabolic thing and measurement yeast phase.The standard method of these detections is summarized in Applied Microbial Physiology, A Practical Approach, P.M.Rhodes and P.F.Stanbury write, IRL Press, 103-129,131-163 and 165-192 page or leaf (ISBN:0199635773) and the reference of wherein quoting.

Embodiment 10: need product from Corynebacterium glutamicum culture purifying

The known the whole bag of tricks in available this area reclaims from the Corynebacterium glutamicum cell of above-mentioned culture or supernatant liquor needs product.Product is not secreted from cell if desired, can be by low-speed centrifugal from the culture harvested cell, and application standard method lysing cell, for example mechanical force or ultrasonic.Centrifugal removal cell debris keeps the supernatant liquor that contains described soluble proteins and partly supplies to be further purified needed compound.If product comes out from Corynebacterium glutamicum emiocytosis, then from described culture, remove cell by low-speed centrifugal, keep supernatant liquor partly for being further purified.

Make and to carry out chromatography from the supernatant liquor part of arbitrary purification process on appropriate resin, perhaps need molecule to be retained on the chromatographic resin and the most of impurity in the sample are washed out, perhaps impurity is retained on the resin and needs to divide a sub-sample to be washed out.Can repeat described chromatographic step as required, use identical or different chromatographic resin.Persons skilled in the art are being selected suitable chromatographic resin and described resin are applied to be proficient in very much aspect the specific molecular to be purified most effectively.Purified product can be housed under the most stable state of temperature of product by filtering or ultrafiltration and concentration.

Many purification process known in the art are arranged, and above-mentioned purification process is not restrictive.Such purification process is described in for example Bailey, J.E.﹠amp; Ollis, D.F., BiochemicalEngineering Fundamentals, McGraw-Hill: New York (1986).

The standard technique of using this area can detect the identity and the purity of separating compound.Described standard technique comprises high performance liquid chromatography (HPLC), spectrography, staining, thin-layer chromatography, NIRS, enzyme assay or microbiological method.The summary of described analytical procedure is seen: Patek etc. (1994) Appl.Environ.Microbiol.60:133-140; Malakhova etc. (1996) Biotekhnologiya 11:27-32; And (1998) Bioprocess Engineer such as Schmidt, 19:67-70; Ulmann ' sEncyclopedia of Industrial Chemistry, (1996) A27 volume, VCH:Weinheim, 89-90,521-540,540-547,559-566,575-581 and 581-587 page or leaf; Michal, G. (1999) Biochemical Pathways:An Atlas of biochemistry and MolecularBiology, John Wiley and Sons; Fallon, the application of A. etc. (1987) HPLC in biological chemistry is stated from: Laboratory Techniques in Biochemistry and Molecular Biology, the 17th volume.

Embodiment 11: analyze gene order of the present invention

Comparative sequences also determines that the homology percentage of two kinds of sequences is technology known in the art, can adopt mathematical algorithm to finish, for example the algorithm of Karlin and Altschul ((1990) Proc.Natl.Acad.Sci.USA 87:2264-68) and modified algorithm (Karlin and Altschul (1993) Proc.Natl.Acad.Sci.USA 90:5873-77 thereof.This algorithm has added NBLAST and the XBLAST program (2.0 editions) of (1990) J.Mol.Biol.215:403-10 such as Altschul.Can use the NBLAST program, marking=100, the retrieval of BLAST Nucleotide is carried out in word string length=12, so that obtain and SMP nucleic acid molecule homologous nucleotide sequence of the present invention.Can use the XBLAT program, marking=50, the retrieval of BLAST protein is carried out in word string length=3, so that obtain and SMP protein molecular homologous aminoacid sequence of the present invention.In order to obtain the band room sequence contrast of comparison purpose, can be according to Altschul etc., (1997) Nucleic Acids Res.25 (17): 3389-3402 is described, uses Gapped BLAST.When using BLAST and Gapped blast program, one skilled in the art will know that how to optimize program (for example XBLAST and the NBLAST) parameter that is used to analyze particular sequence.

Another mathematical algorithm example that is used for the sequence comparison is Meyers and Miller algorithm ((1988) Comput.Appl.Biosci.4:11-17).This algorithm has added ALIGN program (2.0 editions), and the ALIGN program is the integral part of GCG sequence comparison software bag.When using ALIGN program comparing amino acid sequence, can use PAM120 weight residue table, room length point penalty 12 and gap penalty 4.Other sequential analysis algorithm is known in the art, comprises ADVANCE and ADAM that Torelli and Robotti (1994) Comput.Appl.Biosci.10:3-5 introduces; And the FASTA of Pearson and Lipman (1988) P.N.A.S.85:2444-8 introduction.

Also can use GAP program in the GCG software package (can Http:// www.gcg.comObtain), selecting Blosum 62 matrixes or PAM250 matrix and room weight for use is 12,10,8,6 or 4 and the length weight is 2,3 or 4, the homology percentage that obtains two seed amino acid sequences calculates.Use the GAP program in the GCG software package, use canonical parameter, for example room weight 50 and length weight 3 can obtain the homology percentage of two kinds of nucleotide sequences.Adopt methods known in the art (to write (1998) Bioinformatics:A Practical Guide to the Analysis of Genes and Proteins referring to for example Bexevanis and Ouellette, John Wiley and Sons: New York), can carry out the comparative analysis of gene order of the present invention and Genbank sequence.Compare gene order of the present invention and Genbank sequence with 3 step method.The first step is carried out BLASTN to each sequence of the present invention and Genbank nucleotide sequence and is analyzed (for example local comparative analysis), and keeping preceding 500, to hit sequence for further analysis.In second step, hit sequence to these 500 and carry out FASTA retrieval (for example associating is local and the comprehensive comparative analysis of global sequence, wherein arranges contrast sequence localized area).At last, adopt the GAP program (use canonical parameter) in the GCG software package, each gene order of the present invention and preceding 3 FASTA are hit in the sequence each carry out sequence of overall importance and contrast.In order to obtain correct result, use the known method in this area and make the sequence length that takes out from Genbank be adjusted into search sequence length.Analytical results sees Table 4.To analyze the data that obtain identical with separately each gene of the present invention and each reference sequences of Genbank being carried out GAP (overall situation) for the data that obtain, but compare with such database-wide GAP (overall situation) analysis, need computing time significantly reduce.The correlated sequence of the present invention of sequence that does not have acquisition to be higher than threshold value is denoted as in table 4 does not have the sequence comparative information.And then those skilled in the art should be appreciated that the GAP sequence contrast homology percentage under table 4 gauge outfit " homology (%) (GAP) " lists with European digital format, and wherein ", " represents radix point.For example the numerical value " 40,345 " in this hurdle is meant " 40.345% ".

Embodiment 12: make up and the operation dna microarray

In addition, sequence of the present invention can be used for making up and the operation dna microarray (design of DNA array, methodology and use are well-known in the art, and its introduction: Schena is for example arranged in following document, M. etc. (1995) Sfcience 270:467-470; Wodicka, L. etc. (1997) Nature Biotechnology 15:1359-1367; DeSaizieu, A. etc. (1998) NatureBiotechnology 16:45-48; And DeRisi, J.L. etc. (1997) Science 278:680-686).

Dna microarray is solid or flexible holder, is made up of nitrocellulose, nylon, glass, silicone or other material.Nucleic acid molecule combines with support surface is orderly.Suitably behind the mark, other nucleic acid or nucleic acid mixture can be hybridized with immobilized nucleic acid molecule, and marker can be used to monitor and measure each strength of signal of determining the hybrid molecule in the zone.This method can add simultaneously quantitatively the relative quantity or the absolute magnitude of whole or selected nucleic acid in nucleic acid samples or the mixture.Therefore, but dna microarray parallel analysis a plurality of (nearly 6800 or more) expression of nucleic acids (referring to for example Schena, M. (1996) BioEssays 18 (5): 427-431).

Sequence of the present invention can be used to the design oligonucleotides primer, can increase by the nucleic acid amplification reaction such as the polymerase chain reaction regulation zone of one or more Corynebacterium glutamicum genes of this Oligonucleolide primers.5 ' or 3 ' Oligonucleolide primers or suitable joint selected and designed and the PCR product of generation and above-mentioned upholder dielectric surface covalently bound (in addition, referring to for example Schena, M. etc. (1995) Science 270:467-470 introduces) can be made.

According to Wodicka, L. etc. (1997) Nature Biotechnology 15:1359-1367 introduces, also can be by the synthetic nucleic acid microarray that makes up of original position oligonucleotide.Use photolithographic process and make the exposure of matrix explication district.The Nucleotide of exciting light unstable protection group, and adding thus, any change then can not take place in the lucifuge district.Protection subsequently makes at the synthetic different oligonucleotide of definition with the photoactivation circulation.Can on microarray, synthesize gene qualification of the present invention district by the solid phase oligonucleotide is synthetic.

The nucleic acid molecule of the present invention that exists in sample or the mixture of ribonucleotides can with described microarray hybridization.But according to these nucleic acid molecule of standard method mark.In brief, when for example reverse transcription or DNA are synthetic by mixing isotropic substance or fluorescent mark Nucleotide, thereby marker nucleic acid molecule (for example mRNA molecule or dna molecular).Existing introduction about labeling nucleic acid and microarray hybridization (for example be stated from: Schena, M etc. (1995) are the same; Wokicka, L etc. (1997), the same; And DeSaizieu A. etc. (1998), the same).The detection of hybrid molecule and quantitative palpus are fit to the specific marker that mixes.For example according to Schena, M etc. (1995) (the same) but introduce the detection of radioactive labels thing, and for example can detect fluorescent marker according to the method for ((1996) Genome Research 6:639-645) such as Shalon.

As mentioned above, sequence of the present invention is used for the different strains that the dna microarray technology can relatively be analyzed Corynebacterium glutamicum or other Corynebacterium.For example, the nucleic acid array methodology helps according to distribute in the research bacterial strain variation and identifying for specific and/or required strain characteristic such as pathogenic, throughput and stress tolerance important function of gene of each transcript.In addition, utilize the nucleic acid array method can compare expression of gene distribution of the present invention between yeast phase.

Embodiment 13: analysis of cells albumen group motion mechanics (proteomics (Proteomics))

Gene of the present invention, composition and method can be used for studying mutual effect of albumen faciation and kinetics, are called " proteomics ".The target protein group includes but not limited to Corynebacterium glutamicum total protein group (for example and the albumen group of other organism relatively), under specific environment or metabolism condition (for example high temperature between yeast phase or low temperature, perhaps high pH or low pH) have active albumen, cultivating and the development given period has active albumen.

Method that available this area is known such as gel electrophoresis analysis protein group.For example can obtain cell protein, use various electrophoretic techniques the albumen group is separated from each other by cracking or extraction.Sodium lauryl sulphate gel electrophoresis (SDS-PAGE) is mainly according to the molecular weight of albumen protein isolate.Isoelectrofocusing polyacrylamide gel electrophoresis (IEF-PAGE) is by albumen iso-electric point (it not only reflects aminoacid sequence, and modifies after reflecting described protein translation) protein isolate.The sequential combination that another preferred analysis of protein method is IEF-PAGE and SDS-PAGE is called the 2-D-gel electrophoresis and (for example sees following document introduction: Hermann etc. (1998) Electrophoresis 19:3217-3221; Fountoulakis etc. (1998) Electrophoresis 19:1193-1202; Langen etc. (1997) Electrophoresis 18:1184-1192; Antelmann etc. (1997) Electrophoresis 18:1451-1463).Also can use other analysis of protein method to carry out protein separation, for example capillary electrophoresis; Described technology is the known technology in this area.

The available standards technology manifests the albumen that described method is separated as dyeing or mark.Suitable dye is known in the art, comprises Xylene Brilliant Cyanine G, silver-colored dyestuff or fluorescence dye such as SyproRuby (Molecular Probes).(for example in the Corynebacterium glutamicum substratum, contain radio-labeling amino acid or other amyloid protein precursor ³⁵The S-methionine(Met), ³⁵The S-halfcystine, ¹⁴The C-labeled amino acid, ¹⁵The N-labeled amino acid, Or Or ¹³The C-labeled amino acid) can be before it separates the albumen of these cells of mark.Can use fluorescent marker equally.Can extract according to preceding method, separately and separate described labelled protein.

By measuring used dyestuff or marker amount, can further analyze the albumen that described technology manifests.But adopt for example given protein content of optical means quantitative assay, and can compare with other protein content on identical gel or other gel.For example adopt optics comparison, spectrography, scanning of image and gel analysis or, can on gel, carry out albumen relatively by using photographic film and screen.Such technology is that this area is known.

In order to determine any given proteic identity, can adopt direct order-checking or other standard technique.Can use for example N-and/or C-end amino acid order-checking (for example Edman degraded), also can use mass spectroscopy (especially MALDI or ESI technology (referring to (1997) Electrophoresis 18:1184-1192 such as for example Langen)).Protein sequence provided by the invention can be used for by described technical evaluation Corynebacterium glutamicum albumen.

The albumen that the information that described method obtains can be used between the different samples of more various biotic conditions (for example different biologies, different fermentations time point, different culture medium condition or different biotope etc.) exists pattern, protein-active or protein modified.These experiments can be used for various uses separately or with data that other technical tie-up obtains, the behavior of various biologies under for example more given (for example metabolism) situation, improve the throughput of the bacterial strain of producing fine chemicals or improve the productive rate of producing fine chemicals.

Be equal to embodiment

Those skilled in the art will know that or only adopt many embodiments that are equal to of the specific embodiments that normal experiment just can determine that the present invention introduces.Following claims comprise such embodiment that is equal to.

Sequence table

<110>BASF?Aktiengesellschaft

＜120〉the proteinic Corynebacterium glutamicum gene of coding involved in carbon metabolism and energy generation

<130>BGI-126CPPC

<140>PCT/IB00/00943

<141>2000-06-23

<150>60/141,031

<151>1999-06-25

<150>60/143,208

<151>1999-07-09

<150>60/151,572

<151>1999-08-31

<150>DE?19931412.8

<151>1999-07-08

<150>DE?19931413.6

<151>1999-07-08

<150>DE?19931419.5

<151>1999-07-08

<150>DE?19931420.9

<151>1999-07-08

<150>DE?19931424.1

<151>1999-07-08

<150>DE?19931428.4

<151>1999-07-08

<150>DE?19931431.4

<151>1999-07-08

<150>DE?19931433.0

<151>1999-07-08

<150>DE?19931434.9

<151>1999-07-08

<150>DE?19931510.8

<151>1999-07-08

<150>DE?19931562.0

<151>1999-07-08

<150>DE?19931634.1

<151>1999-07-08

<150>DE?19932180.9

<151>1999-07-09

<150>DE?19932227.9

<151>1999-07-09

<150>DE?19932230.9

<151>1999-07-09

<150>DE?19932924.9

<151>1999-07-14

<150>DE?19932973.7

<151>1999-07-14

<150>DE?19933005.0

<151>1999-07-14

<150>DE?19940765.7

<151>1999-08-27

<150>DE?19942076.9

<151>1999-09-03

<150>DE?19942079.3

<151>1999-09-03

<150>DE?19942086.6

<151>1999-09-03

<150>DE?19942087.4

<151>1999-09-03

<150>DE?19942088.2

<151>1999-09-03

<150>DE?19942095.5

<151>1999-09-03

<150>DE?19942123.4

<151>1999-09-03

<150>DE?19942125.0

<151>1999-09-03

<160>784

<210>1

<211>828

<212>DNA

＜213〉Corynebacterium glutamicum (Corynebacterium glutamicum)

<220>

<221>CDS

<222>(101)..(805)

<223>RXS02735

<400>1

gaggagcttc?gccacatgga?tccagatttg?ggctaccagc?acgcactatc?cggcttgtcc?60

agcgtcaagc?tggaaaccgt?ctaaggagaa?atacaacact?atg?gtt?gat?gta?gta 115

Met?Val?Asp?Val?Val

1 5

cgc?gca?cgc?gat?act?gaa?gat?ttg?gtt?gca?cag?gct?gcc?tcc?aaa?ttc 163

Arg?Ala?Arg?Asp?Thr?Glu?Asp?Leu?Val?Ala?Gln?Ala?Ala?Ser?Lys?Phe

10 15 20

att?gag?gtt?gtt?gaa?gca?gca?act?gcc?aat?aat?ggc?acc?gca?cag?gta 211

Ile?Glu?Val?Val?Glu?Ala?Ala?Thr?Ala?Asn?Asn?Gly?Thr?Ala?Gln?Val

25 30 35

gtg?ctc?acc?ggt?ggt?ggc?gcc?ggc?atc?aag?ttg?ctg?gaa?aag?ctc?agc 259

Val?Leu?Thr?Gly?Gly?Gly?Ala?Gly?Ile?Lys?Leu?Leu?Glu?Lys?Leu?Ser

40 45 50

gtt?gat?gcg?gct?gac?ctt?gcc?tgg?gat?cgc?att?cat?gtg?ttc?ttc?ggc 307

Val?Asp?Ala?Ala?Asp?Leu?Ala?Trp?Asp?Arg?Ile?His?Val?Phe?Phe?Gly

55 60 65

gat?gag?cgc?aat?gtc?cct?gtc?agt?gat?tct?gag?tcc?aat?gag?ggc?cag 355

Asp?Glu?Arg?Asn?Val?Pro?Val?Ser?Asp?Ser?Glu?Ser?Asn?Glu?Gly?Gln

70 75 80 85

gct?cgt?gag?gca?ctg?ttg?tcc?aag?gtt?tct?atc?cct?gaa?gcc?aac?att 403

Ala?Arg?Glu?Ala?Leu?Leu?Ser?Lys?Val?Ser?Ile?Pro?Glu?Ala?Asn?Ile

90 95 100

cac?gga?tat?ggt?ctc?ggc?gac?gta?gat?ctt?gca?gag?gca?gcc?cgc?gct 451

His?Gly?Tyr?Gly?Leu?Gly?Asp?Val?Asp?Leu?Ala?Glu?Ala?Ala?Arg?Ala

105 110 115

tac?gaa?gct?gtg?ttg?gat?gaa?ttc?gca?cca?aac?ggc?ttt?gat?ctt?cac 499

Tyr?Glu?Ala?Val?Leu?Asp?Glu?Phe?Ala?Pro?Asn?Gly?Phe?Asp?Leu?His

120 125 130

ctg?ctc?ggc?atg?ggt?ggc?gaa?ggc?cat?atc?aac?tcc?ctg?ttc?cct?cac 547

Leu?Leu?Gly?Met?Gly?Gly?Glu?Gly?His?Ile?Asn?Ser?Leu?Phe?Pro?His

135 140 145

acc?gat?gca?gtc?aag?gaa?tcc?tcc?gca?aag?gtc?atc?gcg?gtg?ttt?gat 595

Thr?Asp?Ala?Val?Lys?Glu?Ser?Ser?Ala?Lys?Val?Ile?Ala?Val?Phe?Asp

150 155 160 165

tcc?cct?aag?cct?cct?tca?gag?cgt?gca?act?cta?acc?ctt?cct?gcg?gtt 643

Ser?Pro?Lys?Pro?Pro?Ser?Glu?Arg?Ala?Thr?Leu?Thr?Leu?Pro?Ala?Val

170 175 180

cac?tcc?gca?aag?cgc?gtg?tgg?ttg?ctg?gtt?tct?ggt?gcg?gag?aag?gct 691

His?Ser?Ala?Lys?Arg?Val?Trp?Leu?Leu?Val?Ser?Gly?Ala?Glu?Lys?Ala

185 190 195

gag?gca?gct?gcg?gcg?atc?gtc?aac?ggt?gag?cct?gct?gtt?gag?tgg?cct 739

Glu?Ala?Ala?Ala?Ala?Ile?Val?Asn?Gly?Glu?Pro?Ala?Val?Glu?Trp?Pro

200 205 210

gct?gct?gga?gct?acc?gga?tct?gag?gaa?acg?gta?ttg?ttc?ttg?gct?gat 787

Ala?Ala?Gly?Ala?Thr?Gly?Ser?Glu?Glu?Thr?Val?Leu?Phe?Leu?Ala?Asp

215 220 225

gat?gct?gca?gga?aat?ctc?taagcagcgc?cagctctaac?aag 828

Asp?Ala?Ala?Gly?Asn?Leu

230 235

<210>2

<211>235

<212>PRT

＜213〉Corynebacterium glutamicum

<400>2

Met?Val?Asp?Val?Val?Arg?Ala?Arg?Asp?Thr?Glu?Asp?Leu?Val?Ala?Gln

1 5 10 15

Ala?Ala?Ser?Lys?Phe?Ile?Glu?Val?Val?Glu?Ala?Ala?Thr?Ala?Asn?Asn

20 25 30

Gly?Thr?Ala?Gln?Val?Val?Leu?Thr?Gly?Gly?Gly?Ala?Gly?Ile?Lys?Leu

35 40 45

Leu?Glu?Lys?Leu?Ser?Val?Asp?Ala?Ala?Asp?Leu?Ala?Trp?Asp?Arg?Ile

50 55 60

His?Val?Phe?Phe?Gly?Asp?Glu?Arg?Asn?Val?Pro?Val?Ser?Asp?Ser?Glu

65 70 75 80

Ser?Asn?Glu?Gly?Gln?Ala?Arg?Glu?Ala?Leu?Leu?Ser?Lys?Val?Ser?Ile

85 90 95

Pro?Glu?Ala?Asn?Ile?His?Gly?Tyr?Gly?Leu?Gly?Asp?Val?Asp?Leu?Ala

100 105 110

Glu?Ala?Ala?Arg?Ala?Tyr?Glu?Ala?Val?Leu?Asp?Glu?Phe?Ala?Pro?Asn

115 120 125

Gly?Phe?Asp?Leu?His?Leu?Leu?Gly?Met?Gly?Gly?Glu?Gly?His?Ile?Asn

130 135 140

Ser?Leu?Phe?Pro?His?Thr?Asp?Ala?Val?Lys?Glu?Ser?Ser?Ala?Lys?Val

145 150 155 160

Ile?Ala?Val?Phe?Asp?Ser?Pro?Lys?Pro?Pro?Ser?Glu?Arg?Ala?Thr?Leu

165 170 175

Thr?Leu?Pro?Ala?Val?His?Ser?Ala?Lys?Arg?Val?Trp?Leu?Leu?Val?Ser

180 185 190

Gly?Ala?Glu?Lys?Ala?Glu?Ala?Ala?Ala?Ala?Ile?Val?Asn?Gly?Glu?Pro

195 200 205

Ala?Val?Glu?Trp?Pro?Ala?Ala?Gly?Ala?Thr?Gly?Ser?Glu?Glu?Thr?Val

210 215 220

Leu?Phe?Leu?Ala?Asp?Asp?Ala?Ala?Gly?Asn?Leu

225 230 235

<210>3

<211>468

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(445)

<223>RXA01626

<400>3

gcaatagcga?atgcgtaatt?aaccacactt?caaacctagc?ccctcaggtg?gaggattccg?60

acattaccgt?ctgaaaaatt?tcatccgtag?gctaaagagc?atg?tcg?aaa?acg?atc 115

Met?Ser?Lys?Thr?Ile

1 5

atc?gtg?cgc?acc?gaa?att?gaa?atc?cct?gga?cac?cca?acc?gcc?atc?cat 163

Ile?Val?Arg?Thr?Glu?Ile?Glu?Ile?Pro?Gly?His?Pro?Thr?Ala?Ile?His

10 15 20

atc?gca?gag?atg?cag?gag?ctt?ccc?cca?tct?gag?gct?caa?ggc?ggc?gtg 211

Ile?Ala?Glu?Met?Gln?Glu?Leu?Pro?Pro?Ser?Glu?Ala?Gln?Gly?Gly?Val

25 30 35

cag?atg?tgc?aaa?atg?cag?cgc?att?att?gaa?cta?gca?gga?act?gcc?gaa 259

Gln?Met?Cys?Lys?Met?Gln?Arg?Ile?Ile?Glu?Leu?Ala?Gly?Thr?Ala?Glu

40 45 50

ggg?gat?gtc?gtt?act?ggt?gca?ggt?gtt?att?ggc?gga?tct?aat?ttc?cag 307

Gly?Asp?Val?Val?Thr?Gly?Ala?Gly?Val?Ile?Gly?Gly?Ser?Asn?Phe?Gln

55 60 65

ctg?aat?aac?gag?cca?aat?gaa?gtg?gtt?ccc?cat?cca?gat?acc?tat?gcg 355

Leu?Asn?Asn?Glu?Pro?Asn?Glu?Val?Val?Pro?His?Pro?Asp?Thr?Tyr?Ala

70 75 80 85

gat?ttc?ccc?gat?atc?aag?gcg?gtt?gtt?atc?tcc?gcg?gag?act?ttt?gaa 403

Asp?Phe?Pro?Asp?Ile?Lys?Ala?Val?Val?Ile?Ser?Ala?Glu?Thr?Phe?Glu

90 95 100

ggc?ctg?tgg?ctg?gaa?gcg?gga?gcg?aag?ttc?cct?ggg?tta?aat 445

Gly?Leu?Trp?Leu?Glu?Ala?Gly?Ala?Lys?Phe?Pro?Gly?Leu?Asn

105 110 115

taaccacttg?cagtataccc?tag 468

<210>4

<211>115

<212>PRT

＜213〉Corynebacterium glutamicum

<400>4

Met?Ser?Lys?Thr?Ile?Ile?Val?Arg?Thr?Glu?Ile?Glu?Ile?Pro?Gly?His

1 5 10 15

Pro?Thr?Ala?Ile?His?Ile?Ala?Glu?Met?Gln?Glu?Leu?Pro?Pro?Ser?Glu

20 25 30

Ala?Gln?Gly?Gly?Val?Gln?Met?Cys?Lys?Met?Gln?Arg?Ile?Ile?Glu?Leu

35 40 45

Ala?Gly?Thr?Ala?Glu?Gly?Asp?Val?Val?Thr?Gly?Ala?Gly?Val?Ile?Gly

50 55 60

Gly?Ser?Asn?Phe?Gln?Leu?Asn?Asn?Glu?Pro?Asn?Glu?Val?Val?Pro?His

65 70 75 80

Pro?Asp?Thr?Tyr?Ala?Asp?Phe?Pro?Asp?Ile?Lys?Ala?Val?Val?Ile?Ser

85 90 95

Ala?Glu?Thr?Phe?Glu?Gly?Leu?Trp?Leu?Glu?Ala?Gly?Ala?Lys?Phe?Pro

100 105 110

Gly?Leu?Asn

115

<210>5

<211>780

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(757)

<223>RXA02245

<400>5

gccacaccgc?cacggcaccg?atgcgatgtt?tgtggcagtg?ctgcgaaaga?agtagacctg?60

tgagctaagt?ggggtagaca?agagggctat?gatttagggc?atg?gca?caa?cgt?act 115

Met?Ala?Gln?Arg?Thr

1 5

cca?cta?atc?gcc?cca?tcc?att?ctt?gct?gct?gat?ttc?tcc?cgc?tta?ggg 163

Pro?Leu?Ile?Ala?Pro?Ser?Ile?Leu?Ala?Ala?Asp?Phe?Ser?Arg?Leu?Gly

10 15 20

gag?cag?gtg?ttg?gct?gtt?cct?gat?gct?gac?tgg?att?cac?gtc?gac?atc 211

Glu?Gln?Val?Leu?Ala?Val?Pro?Asp?Ala?Asp?Trp?Ile?His?Val?Asp?Ile

25 30 35

atg?gac?gga?cac?ttc?gtt?cca?aac?ttg?agc?ttt?ggc?gcg?gat?atc?aca 259

Met?Asp?Gly?His?Phe?Val?Pro?Asn?Leu?Ser?Phe?Gly?Ala?Asp?Ile?Thr

40 45 50

gct?gcg?gtc?aac?cgc?gtt?acg?gac?aaa?gaa?cta?gac?gtc?cac?ctg?atg 307

Ala?Ala?Val?Asn?Arg?Val?Thr?Asp?Lys?Glu?Leu?Asp?Val?His?Leu?Met

55 60 65

atc?gaa?aac?cca?gag?aag?tgg?gtg?gac?aac?tac?atc?gac?gct?ggc?gcg 355

Ile?Glu?Asn?Pro?Glu?Lys?Trp?Val?Asp?Asn?Tyr?Ile?Asp?Ala?Gly?Ala

70 75 80 85

gac?tgc?att?gtt?ttc?cac?gtt?gaa?gcc?acc?gaa?ggt?cac?gtt?gag?ttg 403

Asp?Cys?Ile?Val?Phe?His?Val?Glu?Ala?Thr?Glu?Gly?His?Val?Glu?Leu

90 95 100

gct?aag?tac?atc?cgt?tcc?aag?ggt?gtg?cgt?gca?ggt?ttc?tcc?ctg?cgc 451

Ala?Lys?Tyr?Ile?Arg?Ser?Lys?Gly?Val?Arg?Ala?Gly?Phe?Ser?Leu?Arg

105 110 115

cct?gga?act?ccc?atc?gag?gat?tac?ttg?gat?gac?ctc?gag?cac?ttc?gat 499

Pro?Gly?Thr?Pro?Ile?Glu?Asp?Tyr?Leu?Asp?Asp?Leu?Glu?His?Phe?Asp

120 125 130

gaa?gtc?atc?gtc?atg?agc?gtc?gag?cct?gga?ttc?ggt?ggc?caa?agc?ttc 547

Glu?Val?Ile?Val?Met?Ser?Val?Glu?Pro?Gly?Phe?Gly?Gly?Gln?Ser?Phe

135 140 145

atg?cct?gaa?caa?ctg?gaa?aag?gtt?cgt?acc?ctg?cgc?aag?gtc?atc?gat 595

Met?Pro?Glu?Gln?Leu?Glu?Lys?Val?Arg?Thr?Leu?Arg?Lys?Val?Ile?Asp

150 155 160 165

gag?cgc?ggt?ctg?aac?acc?gtc?atc?gag?atc?gac?ggc?ggc?att?agc?gcc 643

Glu?Arg?Gly?Leu?Asn?Thr?Val?Ile?Glu?Ile?Asp?Gly?Gly?Ile?Ser?Ala

170 175 180

aag?acc?atc?aag?cag?gct?gcc?gac?gct?ggc?gtg?gat?gcc?ttc?gtt?gca 691

Lys?Thr?Ile?Lys?Gln?Ala?Ala?Asp?Ala?Gly?Val?Asp?Ala?Phe?Val?Ala

185 190 195

ggt?tcc?gct?gtg?tac?ggc?gct?gag?gat?ccc?aac?aag?gcg?atc?cag?gag 739

Gly?Ser?Ala?Val?Tyr?Gly?Ala?Glu?Asp?Pro?Asn?Lys?Ala?Ile?Gln?Glu

200 205 210

ttg?cga?gca?ctc?gcg?cag?taaatggatg?ttgcgcacgc?gtt 780

Leu?Arg?Ala?Leu?Ala?Gln

215

<210>6

<211>219

<212>PRT

＜213〉Corynebacterium glutamicum

<400>6

Met?Ala?Gln?Arg?Thr?Pro?Leu?Ile?Ala?Pro?Ser?Ile?Leu?Ala?Ala?Asp

1 5 10 15

Phe?Ser?Arg?Leu?Gly?Glu?Gln?Val?Leu?Ala?Val?Pro?Asp?Ala?Asp?Trp

20 25 30

Ile?His?Val?Asp?Ile?Met?Asp?Gly?His?Phe?Val?Pro?Asn?Leu?Ser?Phe

35 40 45

Gly?Ala?Asp?Ile?Thr?Ala?Ala?Val?Asn?Arg?Val?Thr?Asp?Lys?Glu?Leu

50 55 60

Asp?Val?His?Leu?Met?Ile?Glu?Asn?Pro?Glu?Lys?Trp?Val?Asp?Asn?Tyr

65 70 75 80

Ile?Asp?Ala?Gly?Ala?Asp?Cys?Ile?Val?Phe?His?Val?Glu?Ala?Thr?Glu

85 90 95

Gly?His?Val?Glu?Leu?Ala?Lys?Tyr?Ile?Arg?Ser?Lys?Gly?Val?Arg?Ala

100 105 110

Gly?Phe?Ser?Leu?Arg?Pro?Gly?Thr?Pro?Ile?Glu?Asp?Tyr?Leu?Asp?Asp

115 120 125

Leu?Glu?His?Phe?Asp?Glu?Val?Ile?Val?Met?Ser?Val?Glu?Pro?Gly?Phe

130 135 140

Gly?Gly?Gln?Ser?Phe?Met?Pro?Glu?Gln?Leu?Glu?Lys?Val?Arg?Thr?Leu

145 150 155 160

Arg?Lys?Val?Ile?Asp?Glu?Arg?Gly?Leu?Asn?Thr?Val?Ile?Glu?Ile?Asp

165 170 175

Gly?Gly?Ile?Ser?Ala?Lys?Thr?Ile?Lys?Gln?Ala?Ala?Asp?Ala?Gly?Val

180 185 190

Asp?Ala?Phe?Val?Ala?Gly?Ser?Ala?Val?Tyr?Gly?Ala?Glu?Asp?Pro?Asn

195 200 205

Lys?Ala?Ile?Gln?Glu?Leu?Arg?Ala?Leu?Ala?Gln

210 215

<210>7

<211>442

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(442)

<223>RXA01015

<400>7

ccaagattga?gtcgagctat?tttgcgattt?gtgaaccccc?aaatagggga?aaagtccggg?60

tatccgccgt?tgtgaaaatg?cctgcagtaa?actgacttcc?atg?cgc?gta?tac?ctt 115

Met?Arg?Val?Tyr?Leu

1 5

gga?gca?gac?cac?gct?ggt?ttc?gaa?act?aaa?aat?gca?atc?gca?gaa?cac 163

Gly?Ala?Asp?His?Ala?Gly?Phe?Glu?Thr?Lys?Asn?Ala?Ile?Ala?Glu?His

10 15 20

ctt?aag?gcc?cac?ggc?cac?gaa?gtg?atc?gac?tgc?gga?gcc?cac?acc?tat 211

Leu?Lys?Ala?His?Gly?His?Glu?Val?Ile?Asp?Cys?Gly?Ala?His?Thr?Tyr

25 30 35

gat?gca?gaa?gat?gac?tac?cca?gcc?ttc?tgc?atc?gaa?gca?gct?agc?cgc 259

Asp?Ala?Glu?Asp?Asp?Tyr?Pro?Ala?Phe?Cys?Ile?Glu?Ala?Ala?Ser?Arg

40 45 50

aca?gta?aac?gac?cca?ggc?tca?ctc?ggc?atc?gtc?ctg?ggt?gga?tcc?gga 307

Thr?Val?Asn?Asp?Pro?Gly?Ser?Leu?Gly?Ile?Val?Leu?Gly?Gly?Ser?Gly

55 60 65

aac?ggc?gag?cag?atc?gcc?gcc?aac?aag?gtc?aag?ggt?gca?cgt?tgt?gca 355

Asn?Gly?Glu?Gln?Ile?Ala?Ala?Asn?Lys?Val?Lys?Gly?Ala?Arg?Cys?Ala

70 75 80 85

ctt?gct?tgg?tct?gtt?gaa?act?gca?cgc?ctc?gcc?cgc?gag?cac?aac?aat 403

Leu?Ala?Trp?Ser?Val?Glu?Thr?Ala?Arg?Leu?Ala?Arg?Glu?His?Asn?Asn

90 95 100

gcg?aac?ctc?atc?ggc?atc?ggc?ggc?cgc?atg?cac?tca?gag 442

Ala?Asn?Leu?Ile?Gly?Ile?Gly?Gly?Arg?Met?His?Ser?Glu

105 110

<210>8

<211>114

<212>PRT

＜213〉Corynebacterium glutamicum

<400>8

Met?Arg?Val?Tyr?Leu?Gly?Ala?Asp?His?Ala?Gly?Phe?Glu?Thr?Lys?Asn

1 5 10 15

Ala?Ile?Ala?Glu?His?Leu?Lys?Ala?His?Gly?His?Glu?Val?Ile?Asp?Cys

20 25 30

Gly?Ala?His?Thr?Tyr?Asp?Ala?Glu?Asp?Asp?Tyr?Pro?Ala?Phe?Cys?Ile

35 40 45

Glu?Ala?Ala?Ser?Arg?Thr?Val?Asn?Asp?Pro?Gly?Ser?Leu?Gly?Ile?Val

50 55 60

Leu?Gly?Gly?Ser?Gly?Asn?Gly?Glu?Gln?Ile?Ala?Ala?Asn?Lys?Val?Lys

65 70 75 80

Gly?Ala?Arg?Cys?Ala?Leu?Ala?Trp?Ser?Val?Glu?Thr?Ala?Arg?Leu?Ala

85 90 95

Arg?Glu?His?Asn?Asn?Ala?Asn?Leu?Ile?Gly?Ile?Gly?Gly?Arg?Met?His

100 105 110

Ser?Glu

<210>9

<211>2142

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(2119)

<223>RXN01312

<400>9

gcagttgcgt?acatcgttcc?tgcactggtc?ctgatcggca?acatcaccat?tccgttcgcc?60

atcgctgttg?gttggattgc?gtaaaggtta?ggaagaattt?atg?agc?act?cac?tct 115

Met?Ser?Thr?His?Ser

1 5

gaa?acc?acc?cgc?cca?gag?ttc?atc?cac?cca?gtc?tca?gtc?ctc?cca?gag 163

Glu?Thr?Thr?Arg?Pro?Glu?Phe?Ile?His?Pro?Val?Ser?Val?Leu?Pro?Glu

10 15 20

gtc?tca?gct?ggt?acg?gtc?ctt?gac?gct?gca?gag?cca?gca?ggc?gtt?ccc 211

Val?Ser?Ala?Gly?Thr?Val?Leu?Asp?Ala?Ala?Glu?Pro?Ala?Gly?Val?Pro

25 30 35

acc?aaa?gat?atg?tgg?gaa?tac?caa?aaa?gac?cac?atg?aac?ctg?gtc?tcc 259

Thr?Lys?Asp?Met?Trp?Glu?Tyr?Gln?Lys?Asp?His?Met?Asn?Leu?Val?Ser

40 45 50

cca?ctg?aac?cga?cgc?aag?ttc?cgt?gtc?ctc?gtc?gtt?ggc?acc?ggc?ctg 307

Pro?Leu?Asn?Arg?Arg?Lys?Phe?Arg?Val?Leu?Val?Val?Gly?Thr?Gly?Leu

55 60 65

tcc?ggt?ggt?gct?gca?gca?gca?gcc?ctc?ggc?gaa?ctc?gga?tac?gac?gtc 355

Ser?Gly?Gly?Ala?Ala?Ala?Ala?Ala?Leu?Gly?Glu?Leu?Gly?Tyr?Asp?Val

70 75 80 85

aag?gcg?ttc?acc?tac?cac?gac?gca?cct?cgc?cgt?gcg?cac?tcc?att?gct 403

Lys?Ala?Phe?Thr?Tyr?His?Asp?Ala?Pro?Arg?Arg?Ala?His?Ser?Ile?Ala

90 95 100

gca?cag?ggt?ggc?gtt?aac?tcc?gcc?cgc?ggc?aag?aag?gta?gac?aac?gac 451

Ala?Gln?Gly?Gly?Val?Asn?Ser?Ala?Arg?Gly?Lys?Lys?Val?Asp?Asn?Asp

105 110 115

ggc?gca?tac?cgc?cac?gtc?aag?gac?acc?gtc?aag?ggc?ggc?gac?tac?cgt 499

Gly?Ala?Tyr?Arg?His?Val?Lys?Asp?Thr?Val?Lys?Gly?Gly?Asp?Tyr?Arg

120 125 130

ggt?cgc?gag?tcc?gac?tgc?tgg?cgt?ctc?gcc?gtc?gag?tcc?gtc?cgc?gtc 547

Gly?Arg?Glu?Ser?Asp?Cys?Trp?Arg?Leu?Ala?Val?Glu?Ser?Val?Arg?Val

135 140 145

atc?gac?cac?atg?aac?gcc?atc?ggt?gca?cca?ttc?gcc?cgc?gaa?tac?ggt 595

Ile?Asp?His?Met?Asn?Ala?Ile?Gly?Ala?Pro?Phe?Ala?Arg?Glu?Tyr?Gly

150 155 160 165

ggc?gcc?ttg?gca?acc?cgt?tcc?ttc?ggt?ggt?gtg?cag?gtc?tcc?cgt?acc 643

Gly?Ala?Leu?Ala?Thr?Arg?Ser?Phe?Gly?Gly?Val?Gln?Val?Ser?Arg?Thr

170 175 180

tac?tac?acc?cgt?gga?caa?acc?gga?cag?cag?ctg?cag?ttc?tcc?acc?gca 691

Tyr?Tyr?Thr?Arg?Gly?Gln?Thr?Gly?Gln?Gln?Leu?Gln?Phe?Ser?Thr?Ala

185 190 195

tcc?gca?cta?cag?cgc?cag?atc?cac?ctc?ggc?tcc?gta?gaa?atc?ttc?acc 739

Ser?Ala?Leu?Gln?Arg?Gln?Ile?His?Leu?Gly?Ser?Val?Glu?Ile?Phe?Thr

200 205 210

cat?aac?gaa?atg?gtt?gac?gtc?att?gtc?acc?gaa?cgt?aac?ggt?gaa?aag 787

His?Asn?Glu?Met?Val?Asp?Val?Ile?Val?Thr?Glu?Arg?Asn?Gly?Glu?Lys

215 220 225

cgc?tgc?gaa?ggc?ctg?atc?atg?cgc?aac?ctg?atc?acc?ggc?gag?ctc?acc 835

Arg?Cys?Glu?Gly?Leu?Ile?Met?Arg?Asn?Leu?Ile?Thr?Gly?Glu?Leu?Thr

230 235 240 245

gca?cac?acc?ggc?cat?gcc?gtt?atc?ctg?gca?acc?ggt?ggc?tac?ggc?aac 883

Ala?His?Thr?Gly?His?Ala?Val?Ile?Leu?Ala?Thr?Gly?Gly?Tyr?Gly?Asn

250 255 260

gtg?tac?cac?atg?tcc?acc?ctg?gcc?aag?aac?tcc?aac?gcc?tcg?gcc?atc 931

Val?Tyr?His?Met?Ser?Thr?Leu?Ala?Lys?Asn?Ser?Asn?Ala?Ser?Ala?Ile

265 270 275

atg?cgt?gca?tac?gaa?gcc?ggc?gca?tac?ttc?gcg?tcc?cca?tcg?ttc?atc 979

Met?Arg?Ala?Tyr?Glu?Ala?Gly?Ala?Tyr?Phe?Ala?Ser?Pro?Ser?Phe?Ile

280 285 290

cag?ttc?cac?cca?acc?ggc?ctg?cct?gtg?aac?tcc?acc?tgg?cag?tcc?aag 1027

Gln?Phe?His?Pro?Thr?Gly?Leu?Pro?Val?Asn?Ser?Thr?Trp?Gln?Ser?Lys

295 300 305

acc?att?ctg?atg?tcc?gag?tcg?ctg?cgt?aac?gac?ggc?cgc?atc?tgg?tcc 1075

Thr?Ile?Leu?Met?Ser?Glu?Ser?Leu?Arg?Asn?Asp?Gly?Arg?Ile?Trp?Ser

310 315 320 325

cct?aag?gaa?ccg?aac?gat?aac?cgc?gat?cca?aac?acc?atc?cct?gag?gat 1123

Pro?Lys?Glu?Pro?Asn?Asp?Asn?Arg?Asp?Pro?Asn?Thr?Ile?Pro?Glu?Asp

330 335 340

gag?cgc?gac?tac?ttc?ctg?gag?cgc?cgc?tac?cca?gca?ttc?ggt?aac?ctc 1171

Glu?Arg?Asp?Tyr?Phe?Leu?Glu?Arg?Arg?Tyr?Pro?Ala?Phe?Gly?Asn?Leu

345 350 355

gtc?cca?cgt?gac?gtt?gct?tcc?cgt?gcg?atc?tcc?cag?cag?atc?aat?gct 1219

Val?Pro?Arg?Asp?Val?Ala?Ser?Arg?Ala?Ile?Ser?Gln?Gln?Ile?Asn?Ala

360 365 370

ggt?ctc?ggt?gtt?gga?cct?ctg?aac?aac?gct?gca?tac?ctg?gac?ttc?cgc 1267

Gly?Leu?Gly?Val?Gly?Pro?Leu?Asn?Asn?Ala?Ala?Tyr?Leu?Asp?Phe?Arg

375 380 385

gac?gcc?acc?gag?cgc?ctc?gga?cag?gac?acc?atc?cgc?gag?cgt?tac?tcc 1315

Asp?Ala?Thr?Glu?Arg?Leu?Gly?Gln?Asp?Thr?Ile?Arg?Glu?Arg?Tyr?Ser

390 395 400 405

aac?ctc?ttc?acc?atg?tac?gaa?gag?gca?att?ggc?gag?gac?cca?tac?tcc 1363

Asn?Leu?Phe?Thr?Met?Tyr?Glu?Glu?Ala?Ile?Gly?Glu?Asp?Pro?Tyr?Ser

410 415 420

agc?cca?atg?cgt?att?gca?ccg?acc?tgc?cac?ttc?acc?atg?ggt?ggc?ctc 1411

Ser?Pro?Met?Arg?Ile?Ala?Pro?Thr?Cys?His?Phe?Thr?Met?Gly?Gly?Leu

425 430 435

tgg?act?gac?ttc?aac?gaa?atg?acg?tca?ctc?cca?ggt?ctg?ttc?tgc?gca 1459

Trp?Thr?Asp?Phe?Asn?Glu?Met?Thr?Ser?Leu?Pro?Gly?Leu?Phe?Cys?Ala

440 445 450

ggc?gaa?gca?tcc?tgg?acc?tac?cac?ggt?gca?aac?cgt?ctg?ggc?gca?aac 1507

Gly?Glu?Ala?Ser?Trp?Thr?Tyr?His?Gly?Ala?Asn?Arg?Leu?Gly?Ala?Asn

455 460 465

tcc?ctg?ctc?tcc?gct?tcc?gtc?gat?ggc?tgg?ttc?acc?ctg?cca?ttc?acc 1555

Ser?Leu?Leu?Ser?Ala?Ser?Val?Asp?Gly?Trp?Phe?Thr?Leu?Pro?Phe?Thr

470 475 480 485

atc?cct?aac?tac?ctc?ggc?cca?ttg?ctt?ggc?tcc?gag?cgt?ctg?tca?gag 1603

Ile?Pro?Asn?Tyr?Leu?Gly?Pro?Leu?Leu?Gly?Ser?Glu?Arg?Leu?Ser?Glu

490 495 500

gat?gca?cca?gaa?gca?cag?gca?gcg?att?gcg?cgt?gca?cag?gct?cgc?att 1651

Asp?Ala?Pro?Glu?Ala?Gln?Ala?Ala?Ile?Ala?Arg?Ala?Gln?Ala?Arg?Ile

505 510 515

gac?cgc?ctc?atg?ggc?aac?cgc?cca?gag?tgg?gtc?ggt?gac?aac?gtt?cac 1699

Asp?Arg?Leu?Met?Gly?Asn?Arg?Pro?Glu?Trp?Val?Gly?Asp?Asn?Val?His

520 525 530

gga?cct?gag?tac?tac?cac?cgc?cag?ctt?ggc?gat?atc?ctg?tac?ttc?tcc 1747

Gly?Pro?Glu?Tyr?Tyr?His?Arg?Gln?Leu?Gly?Asp?Ile?Leu?Tyr?Phe?Ser

535 540 545

tgt?ggc?gtt?tcc?cga?aac?gta?gaa?gac?ctc?cag?gat?ggc?atc?aac?aag 1795

Cys?Gly?Val?Ser?Arg?Asn?Val?Glu?Asp?Leu?Gln?Asp?Gly?Ile?Asn?Lys

550 555 560 565

atc?cgt?gcc?ctc?cgc?gat?gac?ttc?tgg?aag?aac?atg?cgc?atc?acc?ggc 1843

Ile?Arg?Ala?Leu?Arg?Asp?Asp?Phe?Trp?Lys?Asn?Met?Arg?Ile?Thr?Gly

570 575 580

agc?acc?gat?gag?atg?aac?cag?gtt?ctc?gaa?tac?gca?gca?cgc?gta?gcc 1891

Ser?Thr?Asp?Glu?Met?Asn?Gln?Val?Leu?Glu?Tyr?Ala?Ala?Arg?Val?Ala

585 590 595

gac?tac?atc?gac?ctc?ggc?gaa?ctc?atg?tgt?gtc?gac?gcc?ctc?gac?cgc 1939

Asp?Tyr?Ile?Asp?Leu?Gly?Glu?Leu?Met?Cys?Val?Asp?Ala?Leu?Asp?Arg

600 605 610

gac?gag?tcc?tgt?ggc?gct?cac?ttc?cgc?gac?gac?cac?ctc?tcc?gaa?gat 1987

Asp?Glu?Ser?Cys?Gly?Ala?His?Phe?Arg?Asp?Asp?His?Leu?Ser?Glu?Asp

615 620 625

ggc?gaa?gca?caa?cgt?gac?gac?caa?aac?tgg?tgc?ttc?gtc?tcc?gca?tgg 2035

Gly?Glu?Ala?Gln?Arg?Asp?Asp?Gln?Asn?Trp?Cys?Phe?Val?Ser?Ala?Trp

630 635 640 645

gaa?cca?ggc?gag?aat?gga?acc?ttc?gtc?tgc?cac?gca?gaa?cca?ctg?ttc 2083

Glu?Pro?Gly?Glu?Asn?Gly?Thr?Phe?Val?Cys?His?Ala?Glu?Pro?Leu?Phe

650 655 660

ttc?gaa?tct?gtc?cca?ctg?cag?aca?agg?aac?tac?aag?taatgaaact 2129

Phe?Glu?Ser?Val?Pro?Leu?Gln?Thr?Arg?Asn?Tyr?Lys

665 670

tacacttgag?atc 2142

<210>10

<211>673

<212>PRT

＜213〉Corynebacterium glutamicum

<400>10

Met?Ser?Thr?His?Ser?Glu?Thr?Thr?Arg?Pro?Glu?Phe?Ile?His?Pro?Val

1 5 10 15

Ser?Val?Leu?Pro?Glu?Val?Ser?Ala?Gly?Thr?Val?Leu?Asp?Ala?Ala?Glu

20 25 30

Pro?Ala?Gly?Val?Pro?Thr?Lys?Asp?Met?Trp?Glu?Tyr?Gln?Lys?Asp?His

35 40 45

Met?Asn?Leu?Val?Ser?Pro?Leu?Asn?Arg?Arg?Lys?Phe?Arg?Val?Leu?Val

50 55 60

Val?Gly?Thr?Gly?Leu?Ser?Gly?Gly?Ala?Ala?Ala?Ala?Ala?Leu?Gly?Glu

65 70 75 80

Leu?Gly?Tyr?Asp?Val?Lys?Ala?Phe?Thr?Tyr?His?Asp?Ala?Pro?Arg?Arg

85 90 95

Ala?His?Ser?Ile?Ala?Ala?Gln?Gly?Gly?Val?Asn?Ser?Ala?Arg?Gly?Lys

100 105 110

Lys?Val?Asp?Asn?Asp?Gly?Ala?Tyr?Arg?His?Val?Lys?Asp?Thr?Val?Lys

115 120 125

Gly?Gly?Asp?Tyr?Arg?Gly?Arg?Glu?Ser?Asp?Cys?Trp?Arg?Leu?Ala?Val

130 135 140

Glu?Ser?Val?Arg?Val?Ile?Asp?His?Met?Asn?Ala?Ile?Gly?Ala?Pro?Phe

145 150 155 160

Ala?Arg?Glu?Tyr?Gly?Gly?Ala?Leu?Ala?Thr?Arg?Ser?Phe?Gly?Gly?Val

165 170 175

Gln?Val?Ser?Arg?Thr?Tyr?Tyr?Thr?Arg?Gly?Gln?Thr?Gly?Gln?Gln?Leu

180 185 190

Gln?Phe?Ser?Thr?Ala?Ser?Ala?Leu?Gln?Arg?Gln?Ile?His?Leu?Gly?Ser

195 200 205

Val?Glu?Ile?Phe?Thr?His?Asn?Glu?Met?Val?Asp?Val?Ile?Val?Thr?Glu

210 215 220

Arg?Asn?Gly?Glu?Lys?Arg?Cys?Glu?Gly?Leu?Ile?Met?Arg?Asn?Leu?Ile

225 230 235 240

Thr?Gly?Glu?Leu?Thr?Ala?His?Thr?Gly?His?Ala?Val?Ile?Leu?Ala?Thr

245 250 255

Gly?Gly?Tyr?Gly?Asn?Val?Tyr?His?Met?Ser?Thr?Leu?Ala?Lys?Asn?Ser

260 265 270

Asn?Ala?Ser?Ala?Ile?Met?Arg?Ala?Tyr?Glu?Ala?Gly?Ala?Tyr?Phe?Ala

275 280 285

Ser?Pro?Ser?Phe?Ile?Gln?Phe?His?Pro?Thr?Gly?Leu?Pro?Val?Asn?Ser

290 295 300

Thr?Trp?Gln?Ser?Lys?Thr?Ile?Leu?Met?Ser?Glu?Ser?Leu?Arg?Asn?Asp

305 310 315 320

Gly?Arg?Ile?Trp?Ser?Pro?Lys?Glu?Pro?Asn?Asp?Asn?Arg?Asp?Pro?Asn

325 330 335

Thr?Ile?Pro?Glu?Asp?Glu?Arg?Asp?Tyr?Phe?Leu?Glu?Arg?Arg?Tyr?Pro

340 345 350

Ala?Phe?Gly?Asn?Leu?Val?Pro?Arg?Asp?Val?Ala?Ser?Arg?Ala?Ile?Ser

355 360 365

Gln?Gln?Ile?Asn?Ala?Gly?Leu?Gly?Val?Gly?Pro?Leu?Asn?Asn?Ala?Ala

370 375 380

Tyr?Leu?Asp?Phe?Arg?Asp?Ala?Thr?Glu?Arg?Leu?Gly?Gln?Asp?Thr?Ile

385 390 395 400

Arg?Glu?Arg?Tyr?Ser?Asn?Leu?Phe?Thr?Met?Tyr?Glu?Glu?Ala?Ile?Gly

405 410 415

Glu?Asp?Pro?Tyr?Ser?Ser?Pro?Met?Arg?Ile?Ala?Pro?Thr?Cys?His?Phe

420 425 430

Thr?Met?Gly?Gly?Leu?Trp?Thr?Asp?Phe?Asn?Glu?Met?Thr?Ser?Leu?Pro

435 440 445

Gly?Leu?Phe?Cys?Ala?Gly?Glu?Ala?Ser?Trp?Thr?Tyr?His?Gly?Ala?Asn

450 455 460

Arg?Leu?Gly?Ala?Asn?Ser?Leu?Leu?Ser?Ala?Ser?Val?Asp?Gly?Trp?Phe

465 470 475 480

Thr?Leu?Pro?Phe?Thr?Ile?Pro?Asn?Tyr?Leu?Gly?Pro?Leu?Leu?Gly?Ser

485 490 495

Glu?Arg?Leu?Ser?Glu?Asp?Ala?Pro?Glu?Ala?Gln?Ala?Ala?Ile?Ala?Arg

500 505 510

Ala?Gln?Ala?Arg?Ile?Asp?Arg?Leu?Met?Gly?Asn?Arg?Pro?Glu?Trp?Val

515 520 525

Gly?Asp?Asn?Val?His?Gly?Pro?Glu?Tyr?Tyr?His?Arg?Gln?Leu?Gly?Asp

530 535 540

Ile?Leu?Tyr?Phe?Ser?Cys?Gly?Val?Ser?Arg?Asn?Val?Glu?Asp?Leu?Gln

545 550 555 560

Asp?Gly?Ile?Asn?Lys?Ile?Arg?Ala?Leu?Arg?Asp?Asp?Phe?Trp?Lys?Asn

565 570 575

Met?Arg?Ile?Thr?Gly?Ser?Thr?Asp?Glu?Met?Asn?Gln?Val?Leu?Glu?Tyr

580 585 590

Ala?Ala?Arg?Val?Ala?Asp?Tyr?Ile?Asp?Leu?Gly?Glu?Leu?Met?Cys?Val

595 600 605

Asp?Ala?Leu?Asp?Arg?Asp?Glu?Ser?Cys?Gly?Ala?His?Phe?Arg?Asp?Asp

610 615 620

His?Leu?Ser?Glu?Asp?Gly?Glu?Ala?Gln?Arg?Asp?Asp?Gln?Asn?Trp?Cys

625 630 635 640

Phe?Val?Ser?Ala?Trp?Glu?Pro?Gly?Glu?Asn?Gly?Thr?Phe?Val?Cys?His

645 650 655

Ala?Glu?Pro?Leu?Phe?Phe?Glu?Ser?Val?Pro?Leu?Gln?Thr?Arg?Asn?Tyr

660 665 670

Lys

<210>11

<211>1100

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(1077)

<223>FRXA01312

<400>11

gag?tcg?ctg?cgt?aac?gac?ggc?cgc?atc?tgg?tcc?cct?aag?gaa?ccg?aac 48

Glu?Ser?Leu?Arg?Asn?Asp?Gly?Arg?Ile?Trp?Ser?Pro?Lys?Glu?Pro?Asn

1 5 10 15

gat?aac?cgc?gat?cca?aac?acc?atc?cct?gag?gat?gag?cgc?gac?tac?ttc 96

Asp?Asn?Arg?Asp?Pro?Asn?Thr?Ile?Pro?Glu?Asp?Glu?Arg?Asp?Tyr?Phe

20 25 30

ctg?gag?cgc?cgc?tac?cca?gca?ttc?ggt?aac?ctc?gtc?cca?cgt?gac?gtt 144

Leu?Glu?Arg?Arg?Tyr?Pro?Ala?Phe?Gly?Asn?Leu?Val?Pro?Arg?Asp?Val

35 40 45

gct?tcc?cgt?gcg?atc?tcc?cag?cag?atc?aat?gct?ggt?ctc?ggt?gtt?gga 192

Ala?Ser?Arg?Ala?Ile?Ser?Gln?Gln?Ile?Asn?Ala?Gly?Leu?Gly?Val?Gly

50 55 60

cct?ctg?aac?aac?gct?gca?tac?ctg?gac?ttc?cgc?gac?gcc?acc?gag?cgc 240

Pro?Leu?Asn?Asn?Ala?Ala?Tyr?Leu?Asp?Phe?Arg?Asp?Ala?Thr?Glu?Arg

65 70 75 80

ctc?gga?cag?gac?acc?atc?cgc?gag?cgt?tac?tcc?aac?ctc?ttc?acc?atg 288

Leu?Gly?Gln?Asp?Thr?Ile?Arg?Glu?Arg?Tyr?Ser?Asn?Leu?Phe?Thr?Met

85 90 95

tac?gaa?gag?gca?att?ggc?gag?gac?cca?tac?tcc?agc?cca?atg?cgt?att 336

Tyr?Glu?Glu?Ala?Ile?Gly?Glu?Asp?Pro?Tyr?Ser?Ser?Pro?Met?Arg?Ile

100 105 110

gca?ccg?acc?tgc?cac?ttc?acc?atg?ggt?ggc?ctc?tgg?act?gac?ttc?aac 384

Ala?Pro?Thr?Cys?His?Phe?Thr?Met?Gly?Gly?Leu?Trp?Thr?Asp?Phe?Asn

115 120 125

gaa?atg?acg?tca?ctc?cca?ggt?ctg?ttc?tgc?gca?ggc?gaa?gca?tcc?tgg 432

Glu?Met?Thr?Ser?Leu?Pro?Gly?Leu?Phe?Cys?Ala?Gly?Glu?Ala?Ser?Trp

130 135 140

acc?tac?cac?ggt?gca?aac?cgt?ctg?ggc?gca?aac?tcc?ctg?ctc?tcc?gct 480

Thr?Tyr?His?Gly?Ala?Asn?Arg?Leu?Gly?Ala?Asn?Ser?Leu?Leu?Ser?Ala

145 150 155 160

tcc?gtc?gat?ggc?tgg?ttc?acc?ctg?cca?ttc?acc?atc?cct?aac?tac?ctc 528

Ser?Val?Asp?Gly?Trp?Phe?Thr?Leu?Pro?Phe?Thr?Ile?Pro?Asn?Tyr?Leu

165 170 175

ggc?cca?ttg?ctt?ggc?tcc?gag?cgt?ctg?tca?gag?gat?gca?cca?gaa?gca 576

Gly?Pro?Leu?Leu?Gly?Ser?Glu?Arg?Leu?Ser?Glu?Asp?Ala?Pro?Glu?Ala

180 185 190

cag?gca?gcg?att?gcg?cgt?gca?cag?gct?cgc?att?gac?cgc?ctc?atg?ggc 624

Gln?Ala?Ala?Ile?Ala?Arg?Ala?Gln?Ala?Arg?Ile?Asp?Arg?Leu?Met?Gly

195 200 205

aac?cgc?cca?gag?tgg?gtc?ggt?gac?aac?gtt?cac?gga?cct?gag?tac?tac 672

Asn?Arg?Pro?Glu?Trp?Val?Gly?Asp?Asn?Val?His?Gly?Pro?Glu?Tyr?Tyr

210 215 220

cac?cgc?cag?ctt?ggc?gat?atc?ctg?tac?ttc?tcc?tgt?ggc?gtt?tcc?cga 720

His?Arg?Gln?Leu?Gly?Asp?Ile?Leu?Tyr?Phe?Ser?Cys?Gly?Val?Ser?Arg

225 230 235 240

aac?gta?gaa?gac?ctc?cag?gat?ggc?atc?aac?aag?atc?cgt?gcc?ctc?cgc 768

Asn?Val?Glu?Asp?Leu?Gln?Asp?Gly?Ile?Asn?Lys?Ile?Arg?Ala?Leu?Arg

245 250 255

gat?gac?ttc?tgg?aag?aac?atg?cgc?atc?acc?ggc?agc?acc?gat?gag?atg 816

Asp?Asp?Phe?Trp?Lys?Asn?Met?Arg?Ile?Thr?Gly?Ser?Thr?Asp?Glu?Met

260 265 270

aac?cag?gtt?ctc?gaa?tac?gca?gca?cgc?gta?gcc?gac?tac?atc?gac?ctc 864

Asn?Gln?Val?Leu?Glu?Tyr?Ala?Ala?Arg?Val?Ala?Asp?Tyr?Ile?Asp?Leu

275 280 285

ggc?gaa?ctc?atg?tgt?gtc?gac?gcc?ctc?gac?cgc?gac?gag?tcc?tgt?ggc 912

Gly?Glu?Leu?Met?Cys?Val?Asp?Ala?Leu?Asp?Arg?Asp?Glu?Ser?Cys?Gly

290 295 300

gct?cac?ttc?cgc?gac?gac?cac?ctc?tcc?gaa?gat?ggc?gaa?gca?caa?cgt 960

Ala?His?Phe?Arg?Asp?Asp?His?Leu?Ser?Glu?Asp?Gly?Glu?Ala?Gln?Arg

305 310 315 320

gac?gac?caa?aac?tgg?tgc?ttc?gtc?tcc?gca?tgg?gaa?cca?ggc?gag?aat 1008

Asp?Asp?Gln?Asn?Trp?Cys?Phe?Val?Ser?Ala?Trp?Glu?Pro?Gly?Glu?Asn

325 330 335

gga?acc?ttc?gtc?tgc?cac?gca?gaa?cca?ctg?ttc?ttc?gaa?tct?gtc?cca 1056

Gly?Thr?Phe?Val?Cys?His?Ala?Glu?Pro?Leu?Phe?Phe?Glu?Ser?Val?Pro

340 345 350

ctg?cag?aca?agg?aac?tac?aag?taatgaaact?tacacttgag?atc 1100

Leu?Gln?Thr?Arg?Asn?Tyr?Lys

355

<210>12

<211>359

<212>PRT

＜213〉Corynebacterium glutamicum

<400>12

Glu?Ser?Leu?Arg?Asn?Asp?Gly?Arg?Ile?Trp?Ser?Pro?Lys?Glu?Pro?Asn

1 5 10 15

Asp?Asn?Arg?Asp?Pro?Asn?Thr?Ile?Pro?Glu?Asp?Glu?Arg?Asp?Tyr?Phe

20 25 30

Leu?Glu?Arg?Arg?Tyr?Pro?Ala?Phe?Gly?Asn?Leu?Val?Pro?Arg?Asp?Val

35 40 45

Ala?Ser?Arg?Ala?Ile?Ser?Gln?Gln?Ile?Asn?Ala?Gly?Leu?Gly?Val?Gly

50 55 60

Pro?Leu?Asn?Asn?Ala?Ala?Tyr?Leu?Asp?Phe?Arg?Asp?Ala?Thr?Glu?Arg

65 70 75 80

Leu?Gly?Gln?Asp?Thr?Ile?Arg?Glu?Arg?Tyr?Ser?Asn?Leu?Phe?Thr?Met

85 90 95

Tyr?Glu?Glu?Ala?Ile?Gly?Glu?Asp?Pro?Tyr?Ser?Ser?Pro?Met?Arg?Ile

100 105 110

Ala?Pro?Thr?Cys?His?Phe?Thr?Met?Gly?Gly?Leu?Trp?Thr?Asp?Phe?Asn

115 120 125

Glu?Met?Thr?Ser?Leu?Pro?Gly?Leu?Phe?Cys?Ala?Gly?Glu?Ala?Ser?Trp

130 135 140

Thr?Tyr?His?Gly?Ala?Asn?Arg?Leu?Gly?Ala?Asn?Ser?Leu?Leu?Ser?Ala

145 150 155 160

Ser?Val?Asp?Gly?Trp?Phe?Thr?Leu?Pro?Phe?Thr?Ile?Pro?Asn?Tyr?Leu

165 170 175

Gly?Pro?Leu?Leu?Gly?Ser?Glu?Arg?Leu?Ser?Glu?Asp?Ala?Pro?Glu?Ala

180 185 190

Gln?Ala?Ala?Ile?Ala?Arg?Ala?Gln?Ala?Arg?Ile?Asp?Arg?Leu?Met?Gly

195 200 205

Asn?Arg?Pro?Glu?Trp?Val?Gly?Asp?Asn?Val?His?Gly?Pro?Glu?Tyr?Tyr

210 215 220

His?Arg?Gln?Leu?Gly?Asp?Ile?Leu?Tyr?Phe?Ser?Cys?Gly?Val?Ser?Arg

225 230 235 240

Asn?Val?Glu?Asp?Leu?Gln?Asp?Gly?Ile?Asn?Lys?Ile?Arg?Ala?Leu?Arg

245 250 255

Asp?Asp?Phe?Trp?Lys?Asn?Met?Arg?Ile?Thr?Gly?Ser?Thr?Asp?Glu?Met

260 265 270

Asn?Gln?Val?Leu?Glu?Tyr?Ala?Ala?Arg?Val?Ala?Asp?Tyr?Ile?Asp?Leu

275 280 285

Gly?Glu?Leu?Met?Cys?Val?Asp?Ala?Leu?Asp?Arg?Asp?Glu?Ser?Cys?Gly

290 295 300

Ala?His?Phe?Arg?Asp?Asp?His?Leu?Ser?Glu?Asp?Gly?Glu?Ala?Gln?Arg

305 310 315 320

Asp?Asp?Gln?Asn?Trp?Cys?Phe?Val?Ser?Ala?Trp?Glu?Pro?Gly?Glu?Asn

325 330 335

Gly?Thr?Phe?Val?Cys?His?Ala?Glu?Pro?Leu?Phe?Phe?Glu?Ser?Val?Pro

340 345 350

Leu?Gln?Thr?Arg?Asn?Tyr?Lys

355

<210>13

<211>1593

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1570)

<223>RXN00231

<400>13

caggactacc?tcgacgccgg?cgccaacttt?gtccgagtcg?gtgccgatgt?ccagcaactc?60

aacgctgctg?gatacgaaaa?gtgaaggaaa?ataacgcatc?atg?act?att?aat?gtt 115

Met?Thr?Ile?Asn?Val

1 5

ttc?gaa?cta?ctt?gtc?aaa?agt?ccc?acg?ggt?cta?ctg?att?ggt?gat?tcc 163

Phe?Glu?Leu?Leu?Val?Lys?Ser?Pro?Thr?Gly?Leu?Leu?Ile?Gly?Asp?Ser

10 15 20

tgg?gtg?gaa?gca?tcc?gac?ggc?ggt?act?ttc?gat?gtg?gaa?aac?cca?gcg 211

Trp?Val?Glu?Ala?Ser?Asp?Gly?Gly?Thr?Phe?Asp?Val?Glu?Asn?Pro?Ala

25 30 35

acg?ggt?gaa?aca?atc?gca?acg?ctc?gcg?tct?gct?act?tcc?gag?gat?gca 259

Thr?Gly?Glu?Thr?Ile?Ala?Thr?Leu?Ala?Ser?Ala?Thr?Ser?Glu?Asp?Ala

40 45 50

ctg?gct?gct?ctt?gat?gct?gca?tgc?gct?gtt?cag?gcc?gag?tgg?gct?agg 307

Leu?Ala?Ala?Leu?Asp?Ala?Ala?Cys?Ala?Val?Gln?Ala?Glu?Trp?Ala?Arg

55 60 65

atg?cca?gcg?cgc?gag?cgt?tct?aat?att?tta?cgc?cgc?ggt?ttt?gag?ctc 355

Met?Pro?Ala?Arg?Glu?Arg?Ser?Asn?Ile?Leu?Arg?Arg?Gly?Phe?Glu?Leu

70 75 80 85

gta?gca?gaa?cgt?gca?gaa?gag?ttc?gcc?acc?ctc?atg?acc?ttg?gaa?atg 403

Val?Ala?Glu?Arg?Ala?Glu?Glu?Phe?Ala?Thr?Leu?Met?Thr?Leu?Glu?Met

90 95 100

ggc?aag?cct?ttg?gct?gaa?gct?cgc?ggc?gaa?gtc?acc?tac?ggc?aac?gaa 451

Gly?Lys?Pro?Leu?Ala?Glu?Ala?Arg?Gly?Glu?Val?Thr?Tyr?Gly?Asn?Glu

105 110 115

ttc?ctg?cgc?tgg?ttc?tct?gag?gaa?gca?gtt?cgt?ctg?tat?ggc?cgt?tac 499

Phe?Leu?Arg?Trp?Phe?Ser?Glu?Glu?Ala?Val?Arg?Leu?Tyr?Gly?Arg?Tyr

120 125 130

gga?acc?aca?cca?gaa?ggc?aac?ttg?cgg?atg?ctg?acc?gcc?ctc?aag?cca 547

Gly?Thr?Thr?Pro?Glu?Gly?Asn?Leu?Arg?Met?Leu?Thr?Ala?Leu?Lys?Pro

135 140 145

gtt?ggc?ccg?tgc?ctc?ctg?atc?acc?cca?tgg?aac?ttc?cca?cta?gca?atg 595

Val?Gly?Pro?Cys?Leu?Leu?Ile?Thr?Pro?Trp?Asn?Phe?Pro?Leu?Ala?Met

150 155 160 165

gct?acc?cgc?aag?gtc?gca?cct?gcg?atc?gct?gca?ggt?tgt?gtc?atg?gtg 643

Ala?Thr?Arg?Lys?Val?Ala?Pro?Ala?Ile?Ala?Ala?Gly?Cys?Val?Met?Val

170 175 180

ctc?aag?cca?gct?cga?ctt?acc?ccg?ctg?acc?tcc?cag?tat?ttt?gct?cag 691

Leu?Lys?Pro?Ala?Arg?Leu?Thr?Pro?Leu?Thr?Ser?Gln?Tyr?Phe?Ala?Gln

185 190 195

acc?atg?ctt?gat?gcc?ggt?ctt?cca?gca?ggt?gtc?ctc?aat?gtg?gtc?tcc 739

Thr?Met?Leu?Asp?Ala?Gly?Leu?Pro?Ala?Gly?Val?Leu?Asn?Val?Val?Ser

200 205 210

ggt?gct?tcc?gcc?tct?gcg?att?tcc?aac?ccg?att?atg?gaa?gac?gat?cgc 787

Gly?Ala?Ser?Ala?Ser?Ala?Ile?Ser?Asn?Pro?Ile?Met?Glu?Asp?Asp?Arg

215 220 225

ctt?cgt?aaa?gtc?tcc?ttc?acc?ggc?tcc?acc?cca?gtt?ggc?cag?cag?ctg 835

Leu?Arg?Lys?Val?Ser?Phe?Thr?Gly?Ser?Thr?Pro?Val?Gly?Gln?Gln?Leu

230 235 240 245

ctc?aaa?aag?gct?gcc?gat?aaa?gtt?ctg?cgc?acc?tcc?atg?gaa?ctt?ggt 883

Leu?Lys?Lys?Ala?Ala?Asp?Lys?Val?Leu?Arg?Thr?Ser?Met?Glu?Leu?Gly

250 255 260

ggc?aac?gca?cct?ttc?att?gtc?ttc?gag?gac?gcc?gac?cta?gat?ctc?gcg 931

Gly?Asn?Ala?Pro?Phe?Ile?Val?Phe?Glu?Asp?Ala?Asp?Leu?Asp?Leu?Ala

265 270 275

atc?gaa?ggt?gcc?atg?ggt?gcc?aaa?atg?cgc?aac?atc?ggc?gaa?gct?tgc 979

Ile?Glu?Gly?Ala?Met?Gly?Ala?Lys?Met?Arg?Asn?Ile?Gly?Glu?Ala?Cys

280 285 290

acc?gca?gcc?aac?cgt?ttc?tta?gtc?cac?gaa?tcc?gtc?gcc?gat?gaa?ttc 1027

Thr?Ala?Ala?Asn?Arg?Phe?Leu?Val?His?Glu?Ser?Val?Ala?Asp?Glu?Phe

295 300 305

ggc?cgt?cgc?ttc?gct?gcc?cgc?ctt?gaa?gag?caa?gtc?cta?ggc?aac?ggc 1075

Gly?Arg?Arg?Phe?Ala?Ala?Arg?Leu?Glu?Glu?Gln?Val?Leu?Gly?Asn?Gly

310 315 320 325

ctc?gac?gaa?ggc?gtc?acc?gtg?ggc?ccc?ctg?gtt?gag?gaa?aaa?gca?cga 1123

Leu?Asp?Glu?Gly?Val?Thr?Val?Gly?Pro?Leu?Val?Glu?Glu?Lys?Ala?Arg

330 335 340

gac?agc?gtt?gca?tcg?ctt?gtc?gac?gcc?gcc?gtc?gcc?gaa?ggt?gcc?acc 1171

Asp?Ser?Val?Ala?Ser?Leu?Val?Asp?Ala?Ala?Val?Ala?Glu?Gly?Ala?Thr

345 350 355

gtc?ctc?acc?ggc?ggc?aag?gcc?ggc?aca?ggt?gca?ggc?tac?ttc?tac?gaa 1219

Val?Leu?Thr?Gly?Gly?Lys?Ala?Gly?Thr?Gly?Ala?Gly?Tyr?Phe?Tyr?Glu

360 365 370

cca?acg?gtg?ctc?acg?gga?gtt?tca?aca?gat?gcg?gct?atc?ctg?aac?gaa 1267

Pro?Thr?Val?Leu?Thr?Gly?Val?Ser?Thr?Asp?Ala?Ala?Ile?Leu?Asn?Glu

375 380 385

gag?atc?ttc?ggt?ccc?gtc?gca?ccg?atc?gtc?acc?ttc?caa?acc?gag?gaa 1315

Glu?Ile?Phe?Gly?Pro?Val?Ala?Pro?Ile?Val?Thr?Phe?Gln?Thr?Glu?Glu

390 395 400 405

gaa?gcc?ctg?cgt?cta?gcc?aac?tcc?acc?gaa?tac?gga?ctg?gcc?tcc?tat 1363

Glu?Ala?Leu?Arg?Leu?Ala?Asn?Ser?Thr?Glu?Tyr?Gly?Leu?Ala?Ser?Tyr

410 415 420

gtg?ttc?acc?cag?gac?acc?tca?cgt?att?ttc?cgc?gtc?tcc?gat?ggt?ctc 1411

Val?Phe?Thr?Gln?Asp?Thr?Ser?Arg?Ile?Phe?Arg?Val?Ser?Asp?Gly?Leu

425 430 435

gag?ttc?ggc?cta?gtg?ggc?gtc?aat?tcc?ggt?gtc?atc?tct?aac?gct?gct 1459

Glu?Phe?Gly?Leu?Val?Gly?Val?Asn?Ser?Gly?Val?Ile?Ser?Asn?Ala?Ala

440 445 450

gca?cct?ttt?ggt?ggc?gta?aaa?caa?tcc?gga?atg?ggc?cgc?gaa?ggt?ggt 1507

Ala?Pro?Phe?Gly?Gly?Val?Lys?Gln?Ser?Gly?Met?Gly?Arg?Glu?Gly?Gly

455 460 465

ctc?gaa?gga?atc?gag?gag?tac?acc?tcc?gtg?cag?tac?atc?ggt?atc?cgg 1555

Leu?Glu?Gly?Ile?Glu?Glu?Tyr?Thr?Ser?Val?Gln?Tyr?Ile?Gly?Ile?Arg

470 475 480 485

gat?cct?tac?gcc?ggc?tagcatctgc?ccctttacaa?atc 1593

Asp?Pro?Tyr?Ala?Gly

490

<210>14

<211>490

<212>PRT

＜213〉Corynebacterium glutamicum

<400>14

Met?Thr?Ile?Asn?Val?Phe?Glu?Leu?Leu?Val?Lys?Ser?Pro?Thr?Gly?Leu

1 5 10 15

Leu?Ile?Gly?Asp?Ser?Trp?Val?Glu?Ala?Ser?Asp?Gly?Gly?Thr?Phe?Asp

20 25 30

Val?Glu?Asn?Pro?Ala?Thr?Gly?Glu?Thr?Ile?Ala?Thr?Leu?Ala?Ser?Ala

35 40 45

Thr?Ser?Glu?Asp?Ala?Leu?Ala?Ala?Leu?Asp?Ala?Ala?Cys?Ala?Val?Gln

50 55 60

Ala?Glu?Trp?Ala?Arg?Met?Pro?Ala?Arg?Glu?Arg?Ser?Asn?Ile?Leu?Arg

65 70 75 80

Arg?Gly?Phe?Glu?Leu?Val?Ala?Glu?Arg?Ala?Glu?Glu?Phe?Ala?Thr?Leu

85 90 95

Met?Thr?Leu?Glu?Met?Gly?Lys?Pro?Leu?Ala?Glu?Ala?Arg?Gly?Glu?Val

100 105 110

Thr?Tyr?Gly?Asn?Glu?Phe?Leu?Arg?Trp?Phe?Ser?Glu?Glu?Ala?Val?Arg

115 120 125

Leu?Tyr?Gly?Arg?Tyr?Gly?Thr?Thr?Pro?Glu?Gly?Asn?Leu?Arg?Met?Leu

130 135 140

Thr?Ala?Leu?Lys?Pro?Val?Gly?Pro?Cys?Leu?Leu?Ile?Thr?Pro?Trp?Asn

145 150 155 160

Phe?Pro?Leu?Ala?Met?Ala?Thr?Arg?Lys?Val?Ala?Pro?Ala?Ile?Ala?Ala

165 170 175

Gly?Cys?Val?Met?Val?Leu?Lys?Pro?Ala?Arg?Leu?Thr?Pro?Leu?Thr?Ser

180 185 190

Gln?Tyr?Phe?Ala?Gln?Thr?Met?Leu?Asp?Ala?Gly?Leu?Pro?Ala?Gly?Val

195 200 205

Leu?Asn?Val?Val?Ser?Gly?Ala?Ser?Ala?Ser?Ala?Ile?Ser?Asn?Pro?Ile

210 215 220

Met?Glu?Asp?Asp?Arg?Leu?Arg?Lys?Val?Ser?Phe?Thr?Gly?Ser?Thr?Pro

225 230 235 240

Val?Gly?Gln?Gln?Leu?Leu?Lys?Lys?Ala?Ala?Asp?Lys?Val?Leu?Arg?Thr

245 250 255

Ser?Met?Glu?Leu?Gly?Gly?Asn?Ala?Pro?Phe?Ile?Val?Phe?Glu?Asp?Ala

260 265 270

Asp?Leu?Asp?Leu?Ala?Ile?Glu?Gly?Ala?Met?Gly?Ala?Lys?Met?Arg?Asn

275 280 285

Ile?Gly?Glu?Ala?Cys?Thr?Ala?Ala?Asn?Arg?Phe?Leu?Val?His?Glu?Ser

290 295 300

Val?Ala?Asp?Glu?Phe?Gly?Arg?Arg?Phe?Ala?Ala?Arg?Leu?Glu?Glu?Gln

305 310 315 320

Val?Leu?Gly?Asn?Gly?Leu?Asp?Glu?Gly?Val?Thr?Val?Gly?Pro?Leu?Val

325 330 335

Glu?Glu?Lys?Ala?Arg?Asp?Ser?Val?Ala?Ser?Leu?Val?Asp?Ala?Ala?Val

340 345 350

Ala?Glu?Gly?Ala?Thr?Val?Leu?Thr?Gly?Gly?Lys?Ala?Gly?Thr?Gly?Ala

355 360 365

Gly?Tyr?Phe?Tyr?Glu?Pro?Thr?Val?Leu?Thr?Gly?Val?Ser?Thr?Asp?Ala

370 375 380

Ala?Ile?Leu?Asn?Glu?Glu?Ile?Phe?Gly?Pro?Val?Ala?Pro?Ile?Val?Thr

385 390 395 400

Phe?Gln?Thr?Glu?Glu?Glu?Ala?Leu?Arg?Leu?Ala?Asn?Ser?Thr?Glu?Tyr

405 410 415

Gly?Leu?Ala?Ser?Tyr?Val?Phe?Thr?Gln?Asp?Thr?Ser?Arg?Ile?Phe?Arg

420 425 430

Val?Ser?Asp?Gly?Leu?Glu?Phe?Gly?Leu?Val?Gly?Val?Asn?Ser?Gly?Val

435 440 445

Ile?Ser?Asn?Ala?Ala?Ala?Pro?Phe?Gly?Gly?Val?Lys?Gln?Ser?Gly?Met

450 455 460

Gly?Arg?Glu?Gly?Gly?Leu?Glu?Gly?Ile?Glu?Glu?Tyr?Thr?Ser?Val?Gln

465 470 475 480

Tyr?Ile?Gly?Ile?Arg?Asp?Pro?Tyr?Ala?Gly

485 490

<210>15

<211>870

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(847)

<223>RXA01311

<400>15

tcgtctccgc?atgggaacca?ggcgagaatg?gaaccttcgt?ctgccacgca?gaaccactgt?60

tcttcgaatc?tgtcccactg?cagacaagga?actacaagta?atg?aaa?ctt?aca?ctt 115

Met?Lys?Leu?Thr?Leu

1 5

gag?atc?tgg?cgt?caa?gca?ggc?cca?act?gcg?gaa?ggc?aag?ttc?gaa?acc 163

Glu?Ile?Trp?Arg?Gln?Ala?Gly?Pro?Thr?Ala?Glu?Gly?Lys?Phe?Glu?Thr

10 15 20

gtc?cag?gtt?gac?gac?gcc?gtc?gcg?cag?atg?tcc?atc?ctg?gag?ctg?ctt 211

Val?Gln?Val?Asp?Asp?Ala?Val?Ala?Gln?Met?Ser?Ile?Leu?Glu?Leu?Leu

25 30 35

gac?cac?gta?aac?aac?aag?ttc?atc?gaa?gaa?ggc?aaa?gaa?cca?ttc?gcg 259

Asp?His?Val?Asn?Asn?Lys?Phe?Ile?Glu?Glu?Gly?Lys?Glu?Pro?Phe?Ala

40 45 50

ttc?gcc?tct?gac?tgc?cgc?gaa?ggc?att?tgt?ggt?acc?tgt?ggt?ctc?ctc 307

Phe?Ala?Ser?Asp?Cys?Arg?Glu?Gly?Ile?Cys?Gly?Thr?Cys?Gly?Leu?Leu

55 60 65

gtg?aac?ggt?cgc?cct?cac?ggc?gcc?gac?cag?aac?aag?cct?gcc?tgt?gcg 355

Val?Asn?Gly?Arg?Pro?His?Gly?Ala?Asp?Gln?Asn?Lys?Pro?Ala?Cys?Ala

70 75 80 85

cag?cgc?ctg?gtc?agc?tac?aag?gaa?ggc?gac?acc?ctc?aag?atc?gaa?cca 403

Gln?Arg?Leu?Val?Ser?Tyr?Lys?Glu?Gly?Asp?Thr?Leu?Lys?Ile?Glu?Pro

90 95 100

ctg?cgt?tcc?gcc?gca?tac?cca?gtg?atc?aag?gac?atg?gtc?gtc?gac?cgc 451

Leu?Arg?Ser?Ala?Ala?Tyr?Pro?Val?Ile?Lys?Asp?Met?Val?Val?Asp?Arg

105 110 115

tcc?gca?ctg?gac?cgt?gtc?atg?gaa?cag?ggt?ggc?tac?gtg?acc?atc?aac 499

Ser?Ala?Leu?Asp?Arg?Val?Met?Glu?Gln?Gly?Gly?Tyr?Val?Thr?Ile?Asn

120 125 130

gca?ggt?acc?gca?cct?gac?gct?gat?acc?ctc?cac?gtc?aac?cac?gaa?acc 547

Ala?Gly?Thr?Ala?Pro?Asp?Ala?Asp?Thr?Leu?His?Val?Asn?His?Glu?Thr

135 140 145

gca?gaa?ctc?gca?ctt?gac?cac?gca?gcc?tgc?atc?ggc?tgt?ggc?gca?tgt 595

Ala?Glu?Leu?Ala?Leu?Asp?His?Ala?Ala?Cys?Ile?Gly?Cys?Gly?Ala?Cys

150 155 160 165

gtt?gct?gcc?tgc?cct?aac?ggc?gca?gca?cac?ctg?ttc?acc?ggc?gca?aag 643

Val?Ala?Ala?Cys?Pro?Asn?Gly?Ala?Ala?His?Leu?Phe?Thr?Gly?Ala?Lys

170 175 180

ctt?gtt?cac?ctc?tcc?ctc?ctc?cca?ctg?ggt?aag?gaa?gag?cgc?gga?ctg 691

Leu?Val?His?Leu?Ser?Leu?Leu?Pro?Leu?Gly?Lys?Glu?Glu?Arg?Gly?Leu

185 190 195

cgt?gca?cgt?aag?atg?gtt?gat?gaa?atg?gaa?acc?aac?ttc?gga?cac?tgc 739

Arg?Ala?Arg?Lys?Met?Val?Asp?Glu?Met?Glu?Thr?Asn?Phe?Gly?His?Cys

200 205 210

tcc?ctc?tac?ggc?gag?tgc?gca?gat?gtc?tgc?ccc?gca?ggc?atc?cca?ctg 787

Ser?Leu?Tyr?Gly?Glu?Cys?Ala?Asp?Val?Cys?Pro?Ala?Gly?Ile?Pro?Leu

215 220 225

acc?gct?gtg?gca?gct?gtc?acc?aag?gaa?cgt?gcg?cgt?gca?gct?ttc?cga 835

Thr?Ala?Val?Ala?Ala?Val?Thr?Lys?Glu?Arg?Ala?Arg?Ala?Ala?Phe?Arg

230 235 240 245

ggc?aaa?gac?gac?tagtctttaa?tccaagtaag?tac 870

Gly?Lys?Asp?Asp

<210>16

<211>249

<212>PRT

＜213〉Corynebacterium glutamicum

<400>16

Met?Lys?Leu?Thr?Leu?Glu?Ile?Trp?Arg?Gln?Ala?Gly?Pro?Thr?Ala?Glu

1 5 10 15

Gly?Lys?Phe?Glu?Thr?Val?Gln?Val?Asp?Asp?Ala?Val?Ala?Gln?Met?Ser

20 25 30

Ile?Leu?Glu?Leu?Leu?Asp?His?Val?Asn?Asn?Lys?Phe?Ile?Glu?Glu?Gly

35 40 45

Lys?Glu?Pro?Phe?Ala?Phe?Ala?Ser?Asp?Cys?Arg?Glu?Gly?Ile?Cys?Gly

50 55 60

Thr?Cys?Gly?Leu?Leu?Val?Asn?Gly?Arg?Pro?His?Gly?Ala?Asp?Gln?Asn

65 70 75 80

Lys?Pro?Ala?Cys?Ala?Gln?Arg?Leu?Val?Ser?Tyr?Lys?Glu?Gly?Asp?Thr

85 90 95

Leu?Lys?Ile?Glu?Pro?Leu?Arg?Ser?Ala?Ala?Tyr?Pro?Val?Ile?Lys?Asp

100 105 110

Met?Val?Val?Asp?Arg?Ser?Ala?Leu?Asp?Arg?Val?Met?Glu?Gln?Gly?Gly

115 120 125

Tyr?Val?Thr?Ile?Asn?Ala?Gly?Thr?Ala?Pro?Asp?Ala?Asp?Thr?Leu?His

130 135 140

Val?Asn?His?Glu?Thr?Ala?Glu?Leu?Ala?Leu?Asp?His?Ala?Ala?Cys?Ile

145 150 155 160

Gly?Cys?Gly?Ala?Cys?Val?Ala?Ala?Cys?Pro?Asn?Gly?Ala?Ala?His?Leu

165 170 175

Phe?Thr?Gly?Ala?Lys?Leu?Val?His?Leu?Ser?Leu?Leu?Pro?Leu?Gly?Lys

180 185 190

Glu?Glu?Arg?Gly?Leu?Arg?Ala?Arg?Lys?Met?Val?Asp?Glu?Met?Glu?Thr

195 200 205

Asn?Phe?Gly?His?Cys?Ser?Leu?Tyr?Gly?Glu?Cys?Ala?Asp?Val?Cys?Pro

210 215 220

Ala?Gly?Ile?Pro?Leu?Thr?Ala?Val?Ala?Ala?Val?Thr?Lys?Glu?Arg?Ala

225 230 235 240

Arg?Ala?Ala?Phe?Arg?Gly?Lys?Asp?Asp

245

<210>17

<211>1530

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1507)

<223>RXA01535

<400>17

acccacctca?ctctaggggt?ggactccagt?gtttcgcgac?aacacaatga?gtaagcttgt?60

gacagccgta?tttaattctc?agtaagaaat?gagtgatttc?atg?acc?gag?cag?gaa 115

Met?Thr?Glu?Gln?Glu

1 5

ttc?cgt?att?gag?cac?gac?acc?atg?ggt?gaa?gtg?aag?gtt?cca?gca?aag 163

Phe?Arg?Ile?Glu?His?Asp?Thr?Met?Gly?Glu?Val?Lys?Val?Pro?Ala?Lys

10 15 20

gct?ctg?tgg?cag?gca?cag?acc?cag?cgc?gct?gtt?gag?aac?ttc?cct?atc 211

Ala?Leu?Trp?Gln?Ala?Gln?Thr?Gln?Arg?Ala?Val?Glu?Asn?Phe?Pro?Ile

25 30 35

tct?ggt?cgt?ggt?ctg?gaa?tcc?gca?cag?atc?cgc?gca?atg?ggt?ctg?ctg 259

Ser?Gly?Arg?Gly?Leu?Glu?Ser?Ala?Gln?Ile?Arg?Ala?Met?Gly?Leu?Leu

40 45 50

aag?gca?gct?tgt?gcg?cag?gta?aac?aag?gac?tcc?ggt?gcg?ctg?gat?gca 307

Lys?Ala?Ala?Cys?Ala?Gln?Val?Asn?Lys?Asp?Ser?Gly?Ala?Leu?Asp?Ala

55 60 65

gag?aag?gca?gat?gcc?atc?att?gca?gct?ggt?aag?gag?atc?gcg?tcc?ggt 355

Glu?Lys?Ala?Asp?Ala?Ile?Ile?Ala?Ala?Gly?Lys?Glu?Ile?Ala?Ser?Gly

70 75 80 85

aag?cat?gac?gct?gag?ttc?cca?att?gat?gtg?ttc?cag?act?ggt?tcc?ggt 403

Lys?His?Asp?Ala?Glu?Phe?Pro?Ile?Asp?Val?Phe?Gln?Thr?Gly?Ser?Gly

90 95 100

act?tcc?tcc?aac?atg?aac?acc?aat?gag?gtt?atc?gct?tcc?atc?gcg?aag 451

Thr?Ser?Ser?Asn?Met?Asn?Thr?Asn?Glu?Val?Ile?Ala?Ser?Ile?Ala?Lys

105 110 115

gct?aac?ggc?gtt?gag?gtt?cac?cca?aat?gac?cac?gtc?aac?atg?ggt?cag 499

Ala?Asn?Gly?Val?Glu?Val?His?Pro?Asn?Asp?His?Val?Asn?Met?Gly?Gln

120 125 130

tcc?tcc?aat?gac?acc?ttc?cct?act?gca?act?cac?gtt?gct?gca?acc?gaa 547

Ser?Ser?Asn?Asp?Thr?Phe?Pro?Thr?Ala?Thr?His?Val?Ala?Ala?Thr?Glu

135 140 145

gct?gct?gtc?aat?gac?ctc?atc?cca?ggc?ctg?aag?gtt?ctg?cac?gag?tct 595

Ala?Ala?Val?Asn?Asp?Leu?Ile?Pro?Gly?Leu?Lys?Val?Leu?His?Glu?Ser

150 155 160 165

ttg?gcg?aag?aag?gct?aac?gag?tgg?tct?gag?gtt?gtt?aag?tcc?ggc?cgc 643

Leu?Ala?Lys?Lys?Ala?Asn?Glu?Trp?Ser?Glu?Val?Val?Lys?Ser?Gly?Arg

170 175 180

acc?cac?ctg?atg?gac?gct?gtt?cca?gta?acc?ctg?ggc?cag?gag?ttc?ggt 691

Thr?His?Leu?Met?Asp?Ala?Val?Pro?Val?Thr?Leu?Gly?Gln?Glu?Phe?Gly

185 190 195

ggc?tac?gct?cgc?cag?atc?cag?ctc?ggc?atc?gag?cgc?gtt?gag?gct?act 739

Gly?Tyr?Ala?Arg?Gln?Ile?Gln?Leu?Gly?Ile?Glu?Arg?Val?Glu?Ala?Thr

200 205 210

ctt?cct?cgc?ctt?ggt?gag?ctg?gct?att?ggt?ggc?acc?gct?gct?ggt?acc 787

Leu?Pro?Arg?Leu?Gly?Glu?Leu?Ala?Ile?Gly?Gly?Thr?Ala?Ala?Gly?Thr

215 220 225

ggt?atc?aac?acc?tcc?gct?gat?ttc?ggc?ggc?aag?gtt?gtt?gct?gaa?ctg 835

Gly?Ile?Asn?Thr?Ser?Ala?Asp?Phe?Gly?Gly?Lys?Val?Val?Ala?Glu?Leu

230 235 240 245

atc?aac?ttg?acc?gac?gtc?aag?gag?ctc?aag?gaa?gct?gag?aac?cac?ttc 883

Ile?Asn?Leu?Thr?Asp?Val?Lys?Glu?Leu?Lys?Glu?Ala?Glu?Asn?His?Phe

250 255 260

gag?gct?cag?gct?gca?cgc?gac?gct?ctt?gtt?gag?ttc?tcc?ggc?gca?atg 931

Glu?Ala?Gln?Ala?Ala?Arg?Asp?Ala?Leu?Val?Glu?Phe?Ser?Gly?Ala?Met

265 270 275

cgc?gtt?atc?gct?gtc?tcc?ttg?tac?aag?atc?gct?aac?gat?atc?cgc?ctc 979

Arg?Val?Ile?Ala?Val?Ser?Leu?Tyr?Lys?Ile?Ala?Asn?Asp?Ile?Arg?Leu

280 285 290

atg?ggc?tcc?ggc?cca?ctg?acc?ggt?ctt?ggc?gag?atc?cgt?ctc?cca?gac 1027

Met?Gly?Ser?Gly?Pro?Leu?Thr?Gly?Leu?Gly?Glu?Ile?Arg?Leu?Pro?Asp

295 300 305

ctg?cag?cca?ggt?tcc?tcc?atc?atg?cca?ggc?aag?gtc?aac?cca?gtt?ctc 1075

Leu?Gln?Pro?Gly?Ser?Ser?Ile?Met?Pro?Gly?Lys?Val?Asn?Pro?Val?Leu

310 315 320 325

tgt?gag?acc?gct?acc?cag?gtt?tcc?gct?cag?gtt?atc?ggc?aat?gac?gca 1123

Cys?Glu?Thr?Ala?Thr?Gln?Val?Ser?Ala?Gln?Val?Ile?Gly?Asn?Asp?Ala

330 335 340

gct?gtt?gcg?ttc?tcc?ggc?acc?cag?ggc?cag?ttc?gag?ctc?aac?gtg?ttc 1171

Ala?Val?Ala?Phe?Ser?Gly?Thr?Gln?Gly?Gln?Phe?Glu?Leu?Asn?Val?Phe

345 350 355

atc?cca?gtg?atg?gct?cgc?aac?gtg?ctt?gag?tcc?gct?cgc?ctg?ctg?gct 1219

Ile?Pro?Val?Met?Ala?Arg?Asn?Val?Leu?Glu?Ser?Ala?Arg?Leu?Leu?Ala

360 365 370

aac?act?tcc?cgc?gtg?ttc?gca?acc?cgt?ctc?gtt?gat?ggc?att?gag?cca 1267

Asn?Thr?Ser?Arg?Val?Phe?Ala?Thr?Arg?Leu?Val?Asp?Gly?Ile?Glu?Pro

375 380 385

aac?gag?gca?cac?atg?aag?gag?ctc?gct?gag?tct?tca?cct?tcc?atc?gtt 1315

Asn?Glu?Ala?His?Met?Lys?Glu?Leu?Ala?Glu?Ser?Ser?Pro?Ser?Ile?Val

390 395 400 405

acc?cca?ctg?aac?tct?gca?atc?ggc?tac?gaa?gct?gct?gca?aag?gtg?gct 1363

Thr?Pro?Leu?Asn?Ser?Ala?Ile?Gly?Tyr?Glu?Ala?Ala?Ala?Lys?Val?Ala

410 415 420

aag?act?gct?ttg?gct?gag?ggc?aag?acc?atc?cgc?cag?act?gtc?atc?gat 1411

Lys?Thr?Ala?Leu?Ala?Glu?Gly?Lys?Thr?Ile?Arg?Gln?Thr?Val?Ile?Asp

425 430 435

ttg?ggc?ttg?gtt?gat?ggc?gag?aag?ctc?acc?gag?gaa?gag?ctg?gac?aag 1459

Leu?Gly?Leu?Val?Asp?Gly?Glu?Lys?Leu?Thr?Glu?Glu?Glu?Leu?Asp?Lys

440 445 450

cgc?ctc?gac?gtt?ctt?gct?atg?gct?cac?acc?gag?cgc?gag?aac?aag?ttc 1507

Arg?Leu?Asp?Val?Leu?Ala?Met?Ala?His?Thr?Glu?Arg?Glu?Asn?Lys?Phe

455 460 465

taaaactaga?acccgataaa?taa 1530

<210>18

<211>469

<212>PRT

＜213〉Corynebacterium glutamicum

<400>18

Met?Thr?Glu?Gln?Glu?Phe?Arg?Ile?Glu?His?Asp?Thr?Met?Gly?Glu?Val

1 5 10 15

Lys?Val?Pro?Ala?Lys?Ala?Leu?Trp?Gln?Ala?Gln?Thr?Gln?Arg?Ala?Val

20 25 30

Glu?Asn?Phe?Pro?Ile?Ser?Gly?Arg?Gly?Leu?Glu?Ser?Ala?Gln?Ile?Arg

35 40 45

Ala?Met?Gly?Leu?Leu?Lys?Ala?Ala?Cys?Ala?Gln?Val?Asn?Lys?Asp?Ser

50 55 60

Gly?Ala?Leu?Asp?Ala?Glu?Lys?Ala?Asp?Ala?Ile?Ile?Ala?Ala?Gly?Lys

65 70 75 80

Glu?Ile?Ala?Ser?Gly?Lys?His?Asp?Ala?Glu?Phe?Pro?Ile?Asp?Val?Phe

85 90 95

Gln?Thr?Gly?Ser?Gly?Thr?Ser?Ser?Asn?Met?Asn?Thr?Asn?Glu?Val?Ile

100 105 110

Ala?Ser?Ile?Ala?Lys?Ala?Asn?Gly?Val?Glu?Val?His?Pro?Asn?Asp?His

115 120 125

Val?Asn?Met?Gly?Gln?Ser?Ser?Asn?Asp?Thr?Phe?ProThr?Ala?Thr?His

130 135 140

Val?Ala?Ala?Thr?Glu?Ala?Ala?Val?Asn?Asp?Leu?Ile?Pro?Gly?Leu?Lys

145 150 155 160

Val?Leu?His?Glu?Ser?Leu?Ala?Lys?Lys?Ala?Asn?Glu?Trp?Ser?Glu?Val

165 170 175

Val?Lys?Ser?Gly?Arg?Thr?His?Leu?Met?Asp?Ala?Val?Pro?Val?Thr?Leu

180 185 190

Gly?Gln?Glu?Phe?Gly?Gly?Tyr?Ala?Arg?Gln?Ile?Gln?Leu?Gly?Ile?Glu

195 200 205

Arg?Val?Glu?Ala?Thr?Leu?Pro?Arg?Leu?Gly?Glu?Leu?Ala?Ile?Gly?Gly

210 215 220

Thr?Ala?Ala?Gly?Thr?Gly?Ile?Asn?Thr?Ser?Ala?Asp?Phe?Gly?Gly?Lys

225 230 235 240

Val?Val?Ala?Glu?Leu?Ile?Asn?Leu?Thr?Asp?Val?Lys?Glu?Leu?Lys?Glu

245 250 255

Ala?Glu?Asn?His?Phe?Glu?Ala?Gln?Ala?Ala?Arg?Asp?Ala?Leu?Val?Glu

260 265 270

Phe?Ser?Gly?Ala?Met?Arg?Val?Ile?Ala?Val?Ser?Leu?Tyr?Lys?Ile?Ala

275 280 285

Asn?Asp?Ile?Arg?Leu?Met?Gly?Ser?Gly?Pro?Leu?Thr?Gly?Leu?Gly?Glu

290 295 300

Ile?Arg?Leu?Pro?Asp?Leu?Gln?Pro?Gly?Ser?Ser?Ile?Met?Pro?Gly?Lys

305 310 315 320

Val?Asn?Pro?Val?Leu?Cys?Glu?Thr?Ala?Thr?Gln?Val?Ser?Ala?Gln?Val

325 330 335

Ile?Gly?Asn?Asp?Ala?Ala?Val?Ala?Phe?Ser?Gly?Thr?Gln?Gly?Gln?Phe

340 345 350

Glu?Leu?Asn?Val?Phe?Ile?Pro?Val?Met?Ala?Arg?Asn?Val?Leu?Glu?Ser

355 360 365

Ala?Arg?Leu?Leu?Ala?Asn?Thr?Ser?Arg?Val?Phe?Ala?Thr?Arg?Leu?Val

370 375 380

Asp?Gly?Ile?Glu?Pro?Asn?Glu?Ala?His?Met?Lys?Glu?Leu?Ala?Glu?Ser

385 390 395 400

Ser?Pro?Ser?Ile?Val?Thr?Pro?Leu?Asn?Ser?Ala?Ile?Gly?Tyr?Glu?Ala

405 410 415

Ala?Ala?Lys?Val?Ala?Lys?Thr?Ala?Leu?Ala?Glu?Gly?Lys?Thr?Ile?Arg

420 425 430

Gln?Thr?Val?Ile?Asp?Leu?Gly?Leu?Val?Asp?Gly?Glu?Lys?Leu?Thr?Glu

435 440 445

Glu?Glu?Leu?Asp?Lys?Arg?Leu?Asp?Val?Leu?Ala?Met?Ala?His?Thr?Glu

450 455 460

Arg?Glu?Asn?Lys?Phe

465

<210>19

<211>1164

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1141)

<223>RXA00517

<400>19

ggtcttagaa?ccagcgtgca?ctgatggcga?ttaaaggggg?ttgcgcctat?acctattgct?60

ggtatacatt?tcggtatacc?taaaccgaat?tgagggattc?atg?cca?gaa?gtc?act 115

Met?Pro?Glu?Val?Thr

1 5

gtc?aac?gcc?caa?caa?ctc?act?gtt?ctc?tgc?aca?gac?atc?ctc?acc?aaa 163

Val?Asn?Ala?Gln?Gln?Leu?Thr?Val?Leu?Cys?Thr?Asp?Ile?Leu?Thr?Lys

10 15 20

act?gga?gta?cct?gca?gca?gac?gcc?cat?ctt?gtc?ggt?gat?agt?ttg?gtg 211

Thr?Gly?Val?Pro?Ala?Ala?Asp?Ala?His?Leu?Val?Gly?Asp?Ser?Leu?Val

25 30 35

cag?gct?gat?ctt?tgg?ggt?cac?ccc?tcc?cac?ggt?gtg?ctt?cga?ctg?cct 259

Gln?Ala?Asp?Leu?Trp?Gly?His?Pro?Ser?His?Gly?Val?Leu?Arg?Leu?Pro

40 45 50

tgg?tat?gtg?cgc?aga?ctc?cac?agt?ggc?gcg?atg?act?aca?cat?gca?cac 307

Trp?Tyr?Val?Arg?Arg?Leu?His?Ser?Gly?Ala?Met?Thr?Thr?His?Ala?His

55 60 65

gtg?gag?gtt?ctc?aat?gat?ttg?ggt?gcc?gtg?ttg?gcg?ttg?gat?gga?cac 355

Val?Glu?Val?Leu?Asn?Asp?Leu?Gly?Ala?Val?Leu?Ala?Leu?Asp?Gly?His

70 75 80 85

aat?gga?atc?ggc?caa?gtt?tta?gct?gat?cat?gct?cgt?aaa?gaa?gca?gtg 403

Asn?Gly?Ile?Gly?Gln?Val?Leu?Ala?Asp?His?Ala?Arg?Lys?Glu?Ala?Val

90 95 100

act?agg?gca?atg?atg?ttc?ggc?atc?ggt?gcg?gtg?tcg?gtg?cgc?aac?tcc 451

Thr?Arg?Ala?Met?Met?Phe?Gly?Ile?Gly?Ala?Val?Ser?Val?Arg?Asn?Ser

105 110 115

aat?cat?ttt?gga?act?gcc?atg?tac?tac?acc?cgg?aaa?gcg?gca?gcg?caa 499

Asn?His?Phe?Gly?Thr?Ala?Met?Tyr?Tyr?Thr?Arg?Lys?Ala?Ala?Ala?Gln

120 125 130

gga?tgt?gtt?tcc?att?ctc?acc?acc?aat?gca?tct?ccg?gcg?atg?gcg?ccc 547

Gly?Cys?Val?Ser?Ile?Leu?Thr?Thr?Asn?Ala?Ser?Pro?Ala?Met?Ala?Pro

135 140 145

tgg?ggt?ggc?aga?gaa?aaa?cgg?atc?ggt?acc?aac?cca?tgg?tct?att?gcg 595

Trp?Gly?Gly?Arg?Glu?Lys?Arg?Ile?Gly?Thr?Asn?Pro?Trp?Ser?Ile?Ala

150 155 160 165

gca?cct?ttt?gga?gaa?acg?gct?acg?gta?gtc?gat?ata?gcc?aat?act?gcg 643

Ala?Pro?Phe?Gly?Glu?Thr?Ala?Thr?Val?Val?Asp?Ile?Ala?Asn?Thr?Ala

170 175 180

gtt?gcg?cgc?gga?aag?atc?tac?cac?gca?cga?cag?aca?aac?atg?ccc?att 691

Val?Ala?Arg?Gly?Lys?Ile?Tyr?His?Ala?Arg?Gln?Thr?Asn?Met?Pro?Ile

185 190 195

cct?gag?act?tgg?gcg?atc?acg?agt?gag?ggc?gca?ccc?acc?acg?gat?cct 739

Pro?Glu?Thr?Trp?Ala?Ile?Thr?Ser?Glu?Gly?Ala?Pro?Thr?Thr?Asp?Pro

200 205 210

gct?gag?gca?atc?aac?ggt?gtc?gtc?ctt?ccc?atg?gct?ggt?cac?aaa?ggt 787

Ala?Glu?Ala?Ile?Asn?Gly?Val?Val?Leu?Pro?Met?Ala?Gly?His?Lys?Gly

215 220 225

tat?gcg?att?agc?ttc?atg?atg?gat?gtg?ctt?tct?gga?gtt?ctc?act?ggt 835

Tyr?Ala?Ile?Ser?Phe?Met?Met?Asp?Val?Leu?Ser?Gly?Val?Leu?Thr?Gly

230 235 240 245

tcc?cag?cac?agc?acc?aag?gta?cat?ggt?ccg?tat?gat?ccc?act?ccc?cca 883

Ser?Gln?His?Ser?Thr?Lys?Val?His?Gly?Pro?Tyr?Asp?Pro?Thr?Pro?Pro

250 255 260

ggt?gga?gct?ggc?cac?ttg?ttc?atc?gcg?ttg?gat?gtt?gca?gcg?ttt?cgc 931

Gly?Gly?Ala?Gly?His?Leu?Phe?Ile?Ala?Leu?Asp?Val?Ala?Ala?Phe?Arg

265 270 275

gat?cca?caa?gat?ttc?gat?gac?gca?ctc?agc?gat?ctg?gtt?ggg?gaa?gtt 979

Asp?Pro?Gln?Asp?Phe?Asp?Asp?Ala?Leu?Ser?Asp?Leu?Val?Gly?Glu?Val

280 285 290

aaa?tcc?act?ccg?aaa?gca?caa?aac?acc?gag?gag?att?ttc?tac?ccc?ggt 1027

Lys?Ser?Thr?Pro?Lys?Ala?Gln?Asn?Thr?Glu?Glu?Ile?Phe?Tyr?Pro?Gly

295 300 305

gaa?tcg?gaa?gac?cgt?gcg?cat?cgg?aaa?aac?tct?gcg?cac?ggt?att?tca 1075

Glu?Ser?Glu?Asp?Arg?Ala?His?Arg?Lys?Asn?Ser?Ala?His?Gly?Ile?Ser

310 315 320 325

ttg?cct?gaa?aaa?acg?tgg?atg?gaa?ctg?caa?gaa?ctg?gca?atc?gag?aac 1123

Leu?Pro?Glu?Lys?Thr?Trp?Met?Glu?Leu?Gln?Glu?Leu?Ala?Ile?Glu?Asn

330 335 340

cat?gtt?gta?act?cac?cgt?tgatctgcgc?gttaaacctg?gcc 1164

His?Val?Val?Thr?His?Arg

345

<210>20

<211>347

<212>PRT

＜213〉Corynebacterium glutamicum

<400>20

Met?Pro?Glu?Val?Thr?Val?Asn?Ala?Gln?Gln?Leu?Thr?Val?Leu?Cys?Thr

1 5 10 15

Asp?Ile?Leu?Thr?Lys?Thr?Gly?Val?Pro?Ala?Ala?Asp?Ala?His?Leu?Val

20 25 30

Gly?Asp?Ser?Leu?Val?Gln?Ala?Asp?Leu?Trp?Gly?His?Pro?Ser?His?Gly

35 40 45

Val?Leu?Arg?Leu?Pro?Trp?Tyr?Val?Arg?Arg?Leu?His?Ser?Gly?Ala?Met

50 55 60

Thr?Thr?His?Ala?His?Val?Glu?Val?Leu?Asn?Asp?Leu?Gly?Ala?Val?Leu

65 70 75 80

Ala?Leu?Asp?Gly?His?Asn?Gly?Ile?Gly?Gln?Val?Leu?Ala?Asp?His?Ala

85 90 95

Arg?Lys?Glu?Ala?Val?Thr?Arg?Ala?Met?Met?Phe?Gly?Ile?Gly?Ala?Val

100 105 110

Ser?Val?Arg?Asn?Ser?Asn?His?Phe?Gly?Thr?Ala?Met?Tyr?Tyr?Thr?Arg

115 120 125

Lys?Ala?Ala?Ala?Gln?Gly?Cys?Val?Ser?Ile?Leu?Thr?Thr?Asn?Ala?Ser

130 135 140

Pro?Ala?Met?Ala?Pro?Trp?Gly?Gly?Arg?Glu?Lys?Arg?Ile?Gly?Thr?Asn

145 150 155 160

Pro?Trp?Ser?Ile?Ala?Ala?Pro?Phe?Gly?Glu?Thr?Ala?Thr?Val?Val?Asp

165 170 175

Ile?Ala?Asn?Thr?Ala?Val?Ala?Arg?Gly?Lys?Ile?Tyr?His?Ala?Arg?Gln

180 185 190

Thr?Asn?Met?Pro?Ile?Pro?Glu?Thr?Trp?Ala?Ile?Thr?Ser?Glu?Gly?Ala

195 200 205

Pro?Thr?Thr?Asp?Pro?Ala?Glu?Ala?Ile?Asn?Gly?Val?Val?Leu?Pro?Met

210 215 220

Ala?Gly?His?Lys?Gly?Tyr?Ala?Ile?Ser?Phe?Met?Met?Asp?Val?Leu?Ser

225 230 235 240

Gly?Val?Leu?Thr?Gly?Ser?Gln?His?Ser?Thr?Lys?Val?His?Gly?Pro?Tyr

245 250 255

Asp?Pro?Thr?Pro?Pro?Gly?Gly?Ala?Gly?His?Leu?Phe?Ile?Ala?Leu?Asp

260 265 270

Val?Ala?Ala?Phe?Arg?Asp?Pro?Gln?Asp?Phe?Asp?Asp?Ala?Leu?Ser?Asp

275 280 285

Leu?Val?Gly?Glu?Val?Lys?Ser?Thr?Pro?Lys?Ala?Gln?Asn?Thr?Glu?Glu

290 295 300

Ile?Phe?Tyr?Pro?Gly?Glu?Ser?Glu?Asp?Arg?Ala?His?Arg?Lys?Asn?Ser

305 310 315 320

Ala?His?Gly?Ile?Ser?Leu?Pro?Glu?Lys?Thr?Trp?Met?Glu?Leu?Gln?Glu

325 330 335

Leu?Ala?Ile?Glu?Asn?His?Val?Val?Thr?His?Arg

340 345

<210>21

<211>1107

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1084)

<223>RXA01350

<400>21

tgcagtatcg?tcaagatcac?ccaaaactgg?tggctgttct?cttttaagcg?ggatagcatg?60

ggttcttaga?ggacccccta?caaggattga?ggattgttta?atg?aat?tcc?ccg?cag 115

Met?Asn?Ser?Pro?Gln

1 5

aac?gtc?tcc?acc?aag?aag?gtc?acc?gtc?acc?ggc?gca?gct?ggt?caa?atc 163

Asn?Val?Ser?Thr?Lys?Lys?Val?Thr?Val?Thr?Gly?Ala?Ala?Gly?Gln?Ile

10 15 20

tct?tat?tca?ctg?ttg?tgg?cgc?atc?gcc?aac?ggt?gaa?gta?ttc?ggc?acc 211

Ser?Tyr?Ser?Leu?Leu?Trp?Arg?Ile?Ala?Asn?Gly?Glu?Val?Phe?Gly?Thr

25 30 35

gac?acc?cct?gta?gaa?ctg?aaa?ctt?ctg?gag?atc?cct?cag?gct?ctt?ggc 259

Asp?Thr?Pro?Val?Glu?Leu?Lys?Leu?Leu?Glu?Ile?Pro?Gln?Ala?Leu?Gly

40 45 50

ggg?gca?gag?ggt?gtg?gct?atg?gaa?ctt?ctg?gat?tct?gcc?ttc?ccc?ctc 307

Gly?Ala?Glu?Gly?Val?Ala?Met?Glu?Leu?Leu?Asp?Ser?Ala?Phe?Pro?Leu

55 60 65

ctg?cga?aac?atc?acc?atc?acc?gcg?gat?gcc?aat?gag?gca?ttc?gac?ggc 355

Leu?Arg?Asn?Ile?Thr?Ile?Thr?Ala?Asp?Ala?Asn?Glu?Ala?Phe?Asp?Gly

70 75 80 85

gct?aat?gcg?gcg?ttt?ttg?gtc?ggt?gcg?aag?cct?cgc?gga?aaa?ggc?gaa 403

Ala?Asn?Ala?Ala?Phe?Leu?Val?Gly?Ala?Lys?Pro?Arg?Gly?Lys?Gly?Glu

90 95 100

gag?cgc?gca?gat?ttg?ctg?gct?aac?aac?ggc?aag?att?ttc?gga?cct?caa 451

Glu?Arg?Ala?Asp?Leu?Leu?Ala?Asn?Asn?Gly?Lys?Ile?Phe?Gly?Pro?Gln

105 110 115

ggt?aaa?gct?atc?aat?gac?aac?gcc?gca?gat?gac?att?cgt?gtc?cta?gtt 499

Gly?Lys?Ala?Ile?Asn?Asp?Asn?Ala?Ala?Asp?Asp?Ile?Arg?Val?Leu?Val

120 125 130

gtt?gga?aac?cca?gcg?aac?acc?aac?gcg?ttg?att?gct?tca?gct?gcg?gcc 547

Val?Gly?Asn?Pro?Ala?Asn?Thr?Asn?Ala?Leu?Ile?Ala?Ser?Ala?Ala?Ala

135 140 145

cca?gat?gtt?cca?gca?tcc?cgc?ttc?aac?gca?atg?atg?cgc?ctt?gat?cac 595

Pro?Asp?Val?Pro?Ala?Ser?Arg?Phe?Asn?Ala?Met?Met?Arg?Leu?Asp?His

150 155 160 165

aac?cgt?gcg?atc?tcc?cag?ctg?gcc?acc?aag?ctt?ggc?cgt?gga?tct?gcg 643

Asn?Arg?Ala?Ile?Ser?Gln?Leu?Ala?Thr?Lys?Leu?Gly?Arg?Gly?Ser?Ala

170 175 180

gaa?ttt?aac?aac?att?gtg?gtc?tgg?gga?aat?cac?tcc?gca?acc?cag?ttc 691

Glu?Phe?Asn?Asn?Ile?Val?Val?Trp?Gly?Asn?His?Ser?Ala?Thr?Gln?Phe

185 190 195

cca?gac?atc?acc?tac?gca?acc?gtt?ggt?gga?gaa?aag?gtc?act?gac?ctg 739

Pro?Asp?Ile?Thr?Tyr?Ala?Thr?Val?Gly?Gly?Glu?Lys?Val?Thr?Asp?Leu

200 205 210

gtt?gat?cac?gat?tgg?tat?gtg?gag?gag?ttc?att?cct?cgc?gtg?gct?aac 787

Val?Asp?His?Asp?Trp?Tyr?Val?Glu?Glu?Phe?Ile?Pro?Arg?Val?Ala?Asn

215 220 225

cgt?ggc?gct?gaa?atc?att?gag?gtc?cgt?gga?aag?tct?tct?gca?gct?tct 835

Arg?Gly?Ala?Glu?Ile?Ile?Glu?Val?Arg?Gly?Lys?Ser?Ser?Ala?Ala?Ser

230 235 240 245

gca?gca?tcc?tct?gcg?att?gat?cac?atg?cgc?gat?tgg?gta?cag?ggc?acc 883

Ala?Ala?Ser?Ser?Ala?Ile?Asp?His?Met?Arg?Asp?Trp?Val?Gln?Gly?Thr

250 255 260

gag?gcg?tgg?tcc?tct?gcg?gca?att?cct?tcc?acc?ggt?gca?tac?ggc?att 931

Glu?Ala?Trp?Ser?Ser?Ala?Ala?Ile?Pro?Ser?Thr?Gly?Ala?Tyr?Gly?Ile

265 270 275

cct?gag?ggc?att?ttt?gtc?ggt?ctg?cca?acc?gta?tcc?cgc?aac?ggt?gag 979

Pro?Glu?Gly?Ile?Phe?Val?Gly?Leu?Pro?Thr?Val?Ser?Arg?Asn?Gly?Glu

280 285 290

tgg?gaa?atc?gtt?gaa?ggc?ctg?gag?att?tcc?gat?ttc?cag?cgc?gcc?cgc 1027

Trp?Glu?Ile?Val?Glu?Gly?Leu?Glu?Ile?Ser?Asp?Phe?Gln?Arg?Ala?Arg

295 300 305

atc?gac?gcg?aat?gct?cag?gaa?ttg?cag?gcc?gag?cgc?gag?gca?gtg?cgc 1075

Ile?Asp?Ala?Asn?Ala?Gln?Glu?Leu?Gln?Ala?Glu?Arg?Glu?Ala?Val?Arg

310 315 320 325

gac?ttg?ctc?taatctttaa?cgcatgactt?cgc 1107

Asp?Leu?Leu

<210>22

<211>328

<212>PRT

＜213〉Corynebacterium glutamicum

<400>22

Met?Asn?Ser?Pro?Gln?Asn?Val?Ser?Thr?Lys?Lys?Val?Thr?Val?Thr?Gly

1 5 10 15

Ala?Ala?Gly?Gln?Ile?Ser?Tyr?Ser?Leu?Leu?Trp?Arg?Ile?Ala?Asn?Gly

20 25 30

Glu?Val?Phe?Gly?Thr?Asp?Thr?Pro?Val?Glu?Leu?Lys?Leu?Leu?Glu?Ile

35 40 45

Pro?Gln?Ala?Leu?Gly?Gly?Ala?Glu?Gly?Val?Ala?Met?Glu?Leu?Leu?Asp

50 55 60

Ser?Ala?Phe?Pro?Leu?Leu?Arg?Asn?Ile?Thr?Ile?Thr?Ala?Asp?Ala?Asn

65 70 75 80

Glu?Ala?Phe?Asp?Gly?Ala?Asn?Ala?Ala?Phe?Leu?Val?Gly?Ala?Lys?Pro

85 90 95

Arg?Gly?Lys?Gly?Glu?Glu?Arg?Ala?Asp?Leu?Leu?Ala?Asn?Asn?Gly?Lys

100 105 110

Ile?Phe?Gly?Pro?Gln?Gly?Lys?Ala?Ile?Asn?Asp?Asn?Ala?Ala?Asp?Asp

115 120 125

Ile?Arg?Val?Leu?Val?Val?Gly?Asn?Pro?Ala?Asn?Thr?Asn?Ala?Leu?Ile

130 135 140

Ala?Ser?Ala?Ala?Ala?Pro?Asp?Val?Pro?Ala?Ser?Arg?Phe?Asn?Ala?Met

145 150 155 160

Met?Arg?Leu?Asp?His?Asn?Arg?Ala?Ile?Ser?Gln?Leu?Ala?Thr?Lys?Leu

165 170 175

Gly?Arg?Gly?Ser?Ala?Glu?Phe?Asn?Asn?Ile?Val?Val?Trp?Gly?Asn?His

180 185 190

Ser?Ala?Thr?Gln?Phe?Pro?Asp?Ile?Thr?Tyr?Ala?Thr?Val?Gly?Gly?Glu

195 200 205

Lys?Val?Thr?Asp?Leu?Val?Asp?His?Asp?Trp?Tyr?Val?Glu?Glu?Phe?Ile

210 215 220

Pro?Arg?Val?Ala?Asn?Arg?Gly?Ala?Glu?Ile?Ile?Glu?Val?Arg?Gly?Lys

225 230 235 240

Ser?Ser?Ala?Ala?Ser?Ala?Ala?Ser?Ser?Ala?Ile?Asp?His?Met?Arg?Asp

245 250 255

Trp?Val?Gln?Gly?Thr?Glu?Ala?Trp?Ser?Ser?Ala?Ala?Ile?Pro?Ser?Thr

260 265 270

Gly?Ala?Tyr?Gly?Ile?Pro?Glu?Gly?Ile?Phe?Val?Gly?Leu?Pro?Thr?Val

275 280 285

Ser?Arg?Asn?Gly?Glu?Trp?Glu?Ile?Val?Glu?Gly?Leu?Glu?Ile?Ser?Asp

290 295 300

Phe?Gln?Arg?Ala?Arg?Ile?Asp?Ala?Asn?Ala?Gln?Glu?Leu?Gln?Ala?Glu

305 310 315 320

Arg?Glu?Ala?Val?Arg?Asp?Leu?Leu

325

<210>23

<211>1092

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1069)

<223>RXA02149

<400>23

ttgcagagtg?aaccacgatg?atggttggac?agctgttgat?agctaatctt?tgaaagatta?60

aattcaccta?aatcctgtgt?agaacgcgag?gggcactctt?atg?cca?caa?aaa?ccg 115

Met?Pro?Gln?Lys?Pro

1 5

gcc?agt?ttc?gcg?gtg?ggc?ttt?gac?atc?ggc?ggc?acc?aac?atg?cga?gcc 163

Ala?Ser?Phe?Ala?Val?Gly?Phe?Asp?Ile?Gly?Gly?Thr?Asn?Met?Arg?Ala

10 15 20

ggg?ctt?gtc?gac?gaa?tcc?ggg?cgc?atc?gtg?acc?agt?ttg?tcg?gcg?ccg 211

Gly?Leu?Val?Asp?Glu?Ser?Gly?Arg?Ile?Val?Thr?Ser?Leu?Ser?Ala?Pro

25 30 35

tcg?ccg?cgc?acg?acg?cag?gca?atg?gaa?cag?ggg?att?ttt?gat?cta?gtc 259

Ser?Pro?Arg?Thr?Thr?Gln?Ala?Met?Glu?Gln?Gly?Ile?Phe?Asp?Leu?Val

40 45 50

gaa?cag?ctc?aag?gcc?gaa?tac?ccg?gtt?ggt?gct?gtg?gga?ctt?gcc?gtc 307

Glu?Gln?Leu?Lys?Ala?Glu?Tyr?Pro?Val?Gly?Ala?Val?Gly?Leu?Ala?Val

55 60 65

gcg?gga?ttt?ttg?gat?cct?gag?tgc?gag?gtt?gtt?cga?ttt?gcc?ccg?cac 355

Ala?Gly?Phe?Leu?Asp?Pro?Glu?Cys?Glu?Val?Val?Arg?Phe?Ala?Pro?His

70 75 80 85

ctt?cct?tgg?cgc?gat?gag?cca?gtg?cgt?gaa?aag?ttg?gaa?aac?ctt?ttg 403

Leu?Pro?Trp?Arg?Asp?Glu?Pro?Val?Arg?Glu?Lys?Leu?Glu?Asn?Leu?Leu

90 95 100

ggc?ctg?cct?gtt?cgt?ttg?gaa?cat?gat?gcc?aac?tca?gca?gcg?tgg?ggt 451

Gly?Leu?Pro?Val?Arg?Leu?Glu?His?Asp?Ala?Asn?Ser?Ala?Ala?Trp?Gly

105 110 115

gag?cat?cgt?ttt?ggt?gca?gct?caa?ggc?gct?gac?aac?tgg?gtt?ttg?ttg 499

Glu?His?Arg?Phe?Gly?Ala?Ala?Gln?Gly?Ala?Asp?Asn?Trp?Val?Leu?Leu

120 125 130

gca?ctc?ggc?act?gga?att?ggt?gca?gcg?ctg?att?gaa?aaa?ggc?gaa?att 547

Ala?Leu?Gly?Thr?Gly?Ile?Gly?Ala?Ala?Leu?Ile?Glu?Lys?Gly?Glu?Ile

135 140 145

tac?cgt?ggt?gca?tat?ggc?acg?gca?cca?gaa?ttt?ggt?cat?ttg?cgt?gtt 595

Tyr?Arg?Gly?Ala?Tyr?Gly?Thr?Ala?Pro?Glu?Phe?Gly?His?Leu?Arg?Val

150 155 160 165

gtt?cgt?ggc?gga?cgc?gca?tgt?gcg?tgt?ggc?aaa?gaa?ggc?tgc?ctg?gag 643

Val?Arg?Gly?Gly?Arg?Ala?Cys?Ala?Cys?Gly?Lys?Glu?Gly?Cys?Leu?Glu

170 175 180

cgt?tac?tgt?tcc?ggt?act?gcc?ttg?gtt?tac?act?gcg?cgt?gaa?ttg?gct 691

Arg?Tyr?Cys?Ser?Gly?Thr?Ala?Leu?Val?Tyr?Thr?Ala?Arg?Glu?Leu?Ala

185 190 195

tcg?cat?ggc?tca?ttc?cgc?aac?agc?ggg?ctg?ttt?gac?aag?atc?aaa?gcc 739

Ser?His?Gly?Ser?Phe?Arg?Asn?Ser?Gly?Leu?Phe?Asp?Lys?Ile?Lys?Ala

200 205 210

gat?ccg?aat?tcc?atc?aat?gga?aaa?acg?atc?act?gcg?gca?gcg?cgc?caa 787

Asp?Pro?Asn?Ser?Ile?Asn?Gly?Lys?Thr?Ile?Thr?Ala?Ala?Ala?Arg?Gln

215 220 225

gaa?gac?cca?ctt?gct?ctc?gcc?gtt?ctg?gaa?gat?ttc?agc?gag?tgg?ctg 835

Glu?Asp?Pro?Leu?Ala?Leu?Ala?Val?Leu?Glu?Asp?Phe?Ser?Glu?Trp?Leu

230 235 240 245

ggc?gaa?act?ttg?gcg?atc?att?gct?gat?gtc?ctt?gac?cca?ggc?atg?atc 883

Gly?Glu?Thr?Leu?Ala?Ile?Ile?Ala?Asp?Val?Leu?Asp?Pro?Gly?Met?Ile

250 255 260

atc?att?ggt?ggc?gga?ctg?tcc?aat?gct?gcc?gac?ctt?tat?ttg?gat?cgc 931

Ile?Ile?Gly?Gly?Gly?Leu?Ser?Asn?Ala?Ala?Asp?Leu?Tyr?Leu?Asp?Arg

265 270 275

tcg?gtc?aac?cac?tat?tcc?acc?cgc?atc?gtc?ggc?gca?gga?tat?cgc?cct 979

Ser?Val?Asn?His?Tyr?Ser?Thr?Arg?Ile?Val?Gly?Ala?Gly?Tyr?Arg?Pro

280 285 290

ttg?gca?cgc?gtt?gcc?aca?gct?cag?ttg?ggt?gcg?gat?gct?ggc?atg?atc 1027

Leu?Ala?Arg?Val?Ala?Thr?Ala?Gln?Leu?Gly?Ala?Asp?Ala?Gly?Met?Ile

295 300 305

ggt?gtc?gct?gat?cta?gct?cga?cgc?tct?gta?gtg?gaa?gcc?aac 1069

Gly?Val?Ala?Asp?Leu?Ala?Arg?Arg?Ser?Val?Val?Glu?Ala?Asn

310 315 320

taggtgtttt?tcggtgggct?gcg 1092

<210>24

<211>323

<212>PRT

＜213〉Corynebacterium glutamicum

<400>24

Met?Pro?Gln?Lys?Pro?Ala?Ser?Phe?Ala?Val?Gly?Phe?Asp?Ile?Gly?Gly

1 5 10 15

Thr?Asn?Met?Arg?Ala?Gly?Leu?Val?Asp?Glu?Ser?Gly?Arg?Ile?Val?Thr

20 25 30

Ser?Leu?Ser?Ala?Pro?Ser?Pro?Arg?Thr?Thr?Gln?Ala?Met?Glu?Gln?Gly

35 40 45

Ile?Phe?Asp?Leu?Val?Glu?Gln?Leu?Lys?Ala?Glu?Tyr?Pro?Val?Gly?Ala

50 55 60

Val?Gly?Leu?Ala?Val?Ala?Gly?Phe?Leu?Asp?Pro?Glu?Cys?Glu?Val?Val

65 70 75 80

Arg?Phe?Ala?Pro?His?Leu?Pro?Trp?Arg?Asp?Glu?Pro?Val?Arg?Glu?Lys

85 90 95

Leu?Glu?Asn?Leu?Leu?Gly?Leu?Pro?Val?Arg?Leu?Glu?His?Asp?Ala?Asn

100 105 110

Ser?Ala?Ala?Trp?Gly?Glu?His?Arg?Phe?Gly?Ala?Ala?Gln?Gly?Ala?Asp

115 120 125

Asn?Trp?Val?Leu?Leu?Ala?Leu?Gly?Thr?Gly?Ile?Gly?Ala?Ala?Leu?Ile

130 135 140

Glu?Lys?Gly?Glu?Ile?Tyr?Arg?Gly?Ala?Tyr?Gly?Thr?Ala?Pro?Glu?Phe

145 150 155 160

Gly?His?Leu?Arg?Val?Val?Arg?Gly?Gly?Arg?Ala?Cys?Ala?Cys?Gly?Lys

165 170 175

Glu?Gly?Cys?Leu?Glu?Arg?Tyr?Cys?Ser?Gly?Thr?Ala?Leu?Val?Tyr?Thr

180 185 190

Ala?Arg?Glu?Leu?Ala?Ser?His?Gly?Ser?Phe?Arg?Asn?Ser?Gly?Leu?Phe

195 200 205

Asp?Lys?Ile?Lys?Ala?Asp?Pro?Asn?Ser?Ile?Asn?Gly?Lys?Thr?Ile?Thr

210 215 220

Ala?Ala?Ala?Arg?Gln?Glu?Asp?Pro?Leu?Ala?Leu?Ala?Val?Leu?Glu?Asp

225 230 235 240

Phe?Ser?Glu?Trp?Leu?Gly?Glu?Thr?Leu?Ala?Ile?Ile?Ala?Asp?Val?Leu

245 250 255

Asp?Pro?Gly?Met?Ile?Ile?Ile?Gly?Gly?Gly?Leu?Ser?Asn?Ala?Ala?Asp

260 265 270

Leu?Tyr?Leu?Asp?Arg?Ser?Val?Asn?His?Tyr?Ser?Thr?Arg?Ile?Val?Gly

275 280 285

Ala?Gly?Tyr?Arg?Pro?Leu?Ala?Arg?Val?Ala?Thr?Ala?Gln?Leu?Gly?Ala

290 295 300

Asp?Ala?Gly?Met?Ile?Gly?Val?Ala?Asp?Leu?Ala?Arg?Arg?Ser?Val?Val

305 310 315 320

Glu?Ala?Asn

<210>25

<211>1785

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1762)

<223>RXA01814

<400>25

tgttaagcca?ccctactccg?tgaattttgc?cgtatctcgt?gcgcacaatt?gcttttgagg?60

ggaagatgaa?gagaaagtat?tggtgtttta?aggagcaaac?atg?gca?cat?gaa?cgc 115

Met?Ala?His?Glu?Arg

1 5

gcc?ggg?caa?ctc?gcc?caa?cca?gaa?gat?ctc?atc?gat?gtt?gcg?gaa?ctg 163

Ala?Gly?Gln?Leu?Ala?Gln?Pro?Glu?Asp?Leu?Ile?Asp?Val?Ala?Glu?Leu

10 15 20

gtc?acc?gca?tat?ttc?acc?cgc?aag?ccg?gac?gtg?aac?aac?cct?gat?cag 211

Val?Thr?Ala?Tyr?Phe?Thr?Arg?Lys?Pro?Asp?Val?Asn?Asn?Pro?Asp?Gln

25 30 35

cag?gtc?gct?ttc?ggc?acc?tcc?gga?cac?cgt?ggc?ttc?gcg?ctg?gac?agc 259

Gln?Val?Ala?Phe?Gly?Thr?Ser?Gly?His?Arg?Gly?Phe?Ala?Leu?Asp?Ser

40 45 50

gct?ttc?aac?gag?gac?cac?atc?ctg?gca?acc?acc?cag?gcg?atc?gtc?gac 307

Ala?Phe?Asn?Glu?Asp?His?Ile?Leu?Ala?Thr?Thr?Gln?Ala?Ile?Val?Asp

55 60 65

tac?cgc?aac?cag?cag?cca?aaa?aac?tgg?gtc?ggc?ccg?ctg?ttt?atc?ggc 355

Tyr?Arg?Asn?Gln?Gln?Pro?Lys?Asn?Trp?Val?Gly?Pro?Leu?Phe?Ile?Gly

70 75 80 85

cgc?gat?acg?cac?gcg?ctg?tcc?gaa?cca?gcg?atg?atc?agc?gcg?ctt?gag 403

Arg?Asp?Thr?His?Ala?Leu?Ser?Glu?Pro?Ala?Met?Ile?Ser?Ala?Leu?Glu

90 95 100

gtc?ctc?att?gcc?aac?gac?gtc?gaa?gtg?ctt?gtc?gac?gcc?gac?ggc?cgc 451

Val?Leu?Ile?Ala?Asn?Asp?Val?Glu?Val?Leu?Val?Asp?Ala?Asp?Gly?Arg

105 110 115

tac?acc?ccg?acg?ccc?gca?gtg?tcc?cac?gcg?atc?cta?cga?cac?aac?gat 499

Tyr?Thr?Pro?Thr?Pro?Ala?Val?Ser?His?Ala?Ile?Leu?Arg?His?Asn?Asp

120 125 130

ggc?atc?atc?ctt?ggc?acc?gca?gga?ccc?tcc?cgc?ccc?tac?gcc?gac?ggc 547

Gly?Ile?Ile?Leu?Gly?Thr?Ala?Gly?Pro?Ser?Arg?Pro?Tyr?Ala?Asp?Gly

135 140 145

atc?gtg?atc?acc?cca?tcc?cac?aac?cct?cct?cgt?gat?ggc?gga?ttc?aaa 595

Ile?Val?Ile?Thr?Pro?Ser?His?Asn?Pro?Pro?Arg?Asp?Gly?Gly?Phe?Lys

150 155 160 165

tac?aac?cca?gcc?aac?ggt?ggc?cct?gca?gat?acc?gac?gcc?acc?gac?tgg 643

Tyr?Asn?Pro?Ala?Asn?Gly?Gly?Pro?Ala?Asp?Thr?Asp?Ala?Thr?Asp?Trp

170 175 180

atc?gcc?aac?cgc?gcc?aac?gat?att?ctg?cgc?ggc?gac?ctt?gca?gac?gtg 691

Ile?Ala?Asn?Arg?Ala?Asn?Asp?Ile?Leu?Arg?Gly?Asp?Leu?Ala?Asp?Val

185 190 195

aag?cga?gtt?cca?gtt?tcc?ggt?gtc?ctc?gac?gag?cgc?acc?act?gcc?tac 739

Lys?Arg?Val?Pro?Val?Ser?Gly?Val?Leu?Asp?Glu?Arg?Thr?Thr?Ala?Tyr

200 205 210

gac?ttc?aag?ggc?att?tac?atc?gct?gac?ctg?cca?aac?gtg?gtc?aac?atc 787

Asp?Phe?Lys?Gly?Ile?Tyr?Ile?Ala?Asp?Leu?Pro?Asn?Val?Val?Asn?Ile

215 220 225

gat?gcc?atc?cgc?gaa?gct?ggt?gtt?cga?atc?ggc?gca?gac?cca?atg?ggt 835

Asp?Ala?Ile?Arg?Glu?Ala?Gly?Val?Arg?Ile?Gly?Ala?Asp?Pro?Met?Gly

230 235 240 245

ggc?gca?tcc?gtg?gat?tac?tgg?ggt?gcc?atc?gca?gaa?acc?cat?ggc?ctc 883

Gly?Ala?Ser?Val?Asp?Tyr?Trp?Gly?Ala?Ile?Ala?Glu?Thr?His?Gly?Leu

250 255 260

aac?ctc?acc?gtg?gtc?aac?cca?cac?gtt?gat?tcc?acc?ttc?cgc?ttc?atg 931

Asn?Leu?Thr?Val?Val?Asn?Pro?His?Val?Asp?Ser?Thr?Phe?Arg?Phe?Met

265 270 275

aca?ttg?gac?acc?gac?ggc?aag?atc?cgc?atg?gac?tgc?tcc?agc?cca?cac 979

Thr?Leu?Asp?Thr?Asp?Gly?Lys?Ile?Arg?Met?Asp?Cys?Ser?Ser?Pro?His

280 285 290

gca?atg?gca?tcg?ctg?att?gac?aac?cga?gac?aag?ttc?gat?gtg?gca?acc 1027

Ala?Met?Ala?Ser?Leu?Ile?Asp?Asn?Arg?Asp?Lys?Phe?Asp?Val?Ala?Thr

295 300 305

ggc?aac?gac?gcc?gac?gcc?gac?cgc?cac?ggc?atc?gtc?acc?cca?gac?gct 1075

Gly?Asn?Asp?Ala?Asp?Ala?Asp?Arg?His?Gly?Ile?Val?Thr?Pro?Asp?Ala

310 315 320 325

ggc?ttg?atg?aac?ccc?aac?cac?tac?ctc?gca?gta?gca?att?gag?tac?ctc 1123

Gly?Leu?Met?Asn?Pro?Asn?His?Tyr?Leu?Ala?Val?Ala?Ile?Glu?Tyr?Leu

330 335 340

ttt?gct?cac?cgc?cca?ggt?tgg?tcc?gca?gat?acc?gca?gtg?ggc?aaa?acc 1171

Phe?Ala?His?Arg?Pro?Gly?Trp?Ser?Ala?Asp?Thr?Ala?Val?Gly?Lys?Thr

345 350 355

ctg?gtc?agc?tcc?tcc?atg?atc?gac?cgc?gtt?gtg?gcg?cag?ctt?ggc?cgc 1219

Leu?Val?Ser?Ser?Ser?Met?Ile?Asp?Arg?Val?Val?Ala?Gln?Leu?Gly?Arg

360 365 370

acc?ctc?gtt?gag?gtt?cca?gtc?gga?ttc?aag?tgg?ttt?gtc?cca?ggt?ttg 1267

Thr?Leu?Val?Glu?Val?Pro?Val?Gly?Phe?Lys?Trp?Phe?Val?Pro?Gly?Leu

375 380 385

atc?tcc?ggc?gaa?atc?gga?ttc?ggt?ggt?gaa?gaa?tcc?gca?ggt?gca?tcc 1315

Ile?Ser?Gly?Glu?Ile?Gly?Phe?Gly?Gly?Glu?Glu?Ser?Ala?Gly?Ala?Ser

390 395 400 405

ttc?ctc?cgc?atg?gac?ggc?acc?acc?tgg?tcc?acc?gac?aag?gac?ggc?ctc 1363

Phe?Leu?Arg?Met?Asp?Gly?Thr?Thr?Trp?Ser?Thr?Asp?Lys?Asp?Gly?Leu

410 415 420

atc?ctt?gac?ctc?ctg?gca?gct?gag?atc?att?gca?gta?acc?ggc?aag?acc 1411

Ile?Leu?Asp?Leu?Leu?Ala?Ala?Glu?Ile?Ile?Ala?Val?Thr?Gly?Lys?Thr

425 430 435

cca?tca?cag?cgc?tac?gca?gaa?ctc?gcc?gaa?gaa?ttc?ggt?gca?cct?gcc 1459

Pro?Ser?Gln?Arg?Tyr?Ala?Glu?Leu?Ala?Glu?Glu?Phe?Gly?Ala?Pro?Ala

440 445 450

tac?gcc?cgc?acc?gat?gca?gaa?gcc?aac?cga?gaa?caa?aag?gcc?atc?ctg 1507

Tyr?Ala?Arg?Thr?Asp?Ala?Glu?Ala?Asn?Arg?Glu?Gln?Lys?Ala?Ile?Leu

455 460 465

aag?gca?ctg?tcc?cca?gaa?cag?gtc?acc?gcc?acc?gaa?cta?gcc?ggc?gaa 1555

Lys?Ala?Leu?Ser?Pro?Glu?Gln?Val?Thr?Ala?Thr?Glu?Leu?Ala?Gly?Glu

470 475 480 485

gca?atc?acc?gct?aag?ctc?acc?gaa?gct?ccc?ggc?aat?ggc?gca?gcc?atc 1603

Ala?Ile?Thr?Ala?Lys?Leu?Thr?Glu?Ala?Pro?Gly?Asn?Gly?Ala?Ala?Ile

490 495 500

gga?gga?cta?aaa?gtg?acc?acc?gaa?aac?gcc?tgg?ttc?gca?gca?cgc?cca 1651

Gly?Gly?Leu?Lys?Val?Thr?Thr?Glu?Asn?Ala?Trp?Phe?Ala?Ala?Arg?Pro

505 510 515

tcc?ggc?acc?gaa?gac?aag?tac?aag?atc?tac?gca?gaa?tcc?ttc?aag?ggc 1699

Ser?Gly?Thr?Glu?Asp?Lys?Tyr?Lys?Ile?Tyr?Ala?Glu?Ser?Phe?Lys?Gly

520 525 530

gaa?gag?cac?ctc?gcc?cag?gtt?cag?aag?gaa?gcc?caa?gcg?ttg?gtc?agc 1747

Glu?Glu?His?Leu?Ala?Gln?Val?Gln?Lys?Glu?Ala?Gln?Ala?Leu?Val?Ser

535 540 545

gaa?gta?ctc?gga?cag?taaaactgcg?gacttgctga?caa 1785

Glu?Val?Leu?Gly?Gln

550

<210>26

<211>554

<212>PRT

＜213〉Corynebacterium glutamicum

<400>26

Met?Ala?His?Glu?Arg?Ala?Gly?Gln?Leu?Ala?Gln?Pro?Glu?Asp?Leu?Ile

1 5 10 15

Asp?Val?Ala?Glu?Leu?Val?Thr?Ala?Tyr?Phe?Thr?Arg?Lys?Pro?Asp?Val

20 25 30

Asn?Asn?Pro?Asp?Gln?Gln?Val?Ala?Phe?Gly?Thr?Ser?Gly?His?Arg?Gly

35 40 45

Phe?Ala?Leu?Asp?Ser?Ala?Phe?Asn?Glu?Asp?His?Ile?Leu?Ala?Thr?Thr

50 55 60

Gln?Ala?Ile?Val?Asp?Tyr?Arg?Asn?Gln?Gln?Pro?Lys?Asn?Trp?Val?Gly

65 70 75 80

Pro?Leu?Phe?Ile?Gly?Arg?Asp?Thr?His?Ala?Leu?Ser?Glu?Pro?Ala?Met

85 90 95

Ile?Ser?Ala?Leu?Glu?Val?Leu?Ile?Ala?Asn?Asp?Val?Glu?Val?Leu?Val

100 105 110

Asp?Ala?Asp?Gly?Arg?Tyr?Thr?Pro?Thr?Pro?Ala?Val?Ser?His?Ala?Ile

115 120 125

Leu?Arg?His?Asn?Asp?Gly?Ile?Ile?Leu?Gly?Thr?Ala?Gly?Pro?Ser?Arg

130 135 140

Pro?Tyr?Ala?Asp?Gly?Ile?Val?Ile?Thr?Pro?Ser?His?Asn?Pro?Pro?Arg

145 150 155 160

Asp?Gly?Gly?Phe?Lys?Tyr?Asn?Pro?Ala?Asn?Gly?Gly?Pro?Ala?Asp?Thr

165 170 175

Asp?Ala?Thr?Asp?Trp?Ile?Ala?Asn?Arg?Ala?Asn?Asp?Ile?Leu?Arg?Gly

180 185 190

Asp?Leu?Ala?Asp?Val?Lys?Arg?Val?Pro?Val?Ser?Gly?Val?Leu?Asp?Glu

195 200 205

Arg?Thr?Thr?Ala?Tyr?Asp?Phe?Lys?Gly?Ile?Tyr?Ile?Ala?Asp?Leu?Pro

210 215 220

Asn?Val?Val?Asn?Ile?Asp?Ala?Ile?Arg?Glu?Ala?Gly?Val?Arg?Ile?Gly

225 230 235 240

Ala?Asp?Pro?Met?Gly?Gly?Ala?Ser?Val?Asp?Tyr?Trp?Gly?Ala?Ile?Ala

245 250 255

Glu?Thr?His?Gly?Leu?Asn?Leu?Thr?Val?Val?Asn?Pro?His?Val?Asp?Ser

260 265 270

Thr?Phe?Arg?Phe?Met?Thr?Leu?Asp?Thr?Asp?Gly?Lys?Ile?Arg?Met?Asp

275 280 285

Cys?Ser?Ser?Pro?His?Ala?Met?Ala?Ser?Leu?Ile?Asp?Asn?Arg?Asp?Lys

290 295 300

Phe?Asp?Val?Ala?Thr?Gly?Asn?Asp?Ala?Asp?Ala?Asp?Arg?His?Gly?Ile

305 310 315 320

Val?Thr?Pro?Asp?Ala?Gly?Leu?Met?Asn?Pro?Asn?His?Tyr?Leu?Ala?Val

325 330 335

Ala?Ile?Glu?Tyr?Leu?Phe?Ala?His?Arg?Pro?Gly?Trp?Ser?Ala?Asp?Thr

340 345 350

Ala?Val?Gly?Lys?Thr?Leu?Val?Ser?Ser?Ser?Met?Ile?Asp?Arg?Val?Val

355 360 365

Ala?Gln?Leu?Gly?Arg?Thr?Leu?Val?Glu?Val?Pro?Val?Gly?Phe?Lys?Trp

370 375 380

Phe?Val?Pro?Gly?Leu?Ile?Ser?Gly?Glu?Ile?Gly?Phe?Gly?Gly?Glu?Glu

385 390 395 400

Ser?Ala?Gly?Ala?Ser?Phe?Leu?Arg?Met?Asp?Gly?Thr?Thr?Trp?Ser?Thr

405 410 415

Asp?Lys?Asp?Gly?Leu?Ile?Leu?Asp?Leu?Leu?Ala?Ala?Glu?Ile?Ile?Ala

420 425 430

Val?Thr?Gly?Lys?Thr?Pro?Ser?Gln?Arg?Tyr?Ala?Glu?Leu?Ala?Glu?Glu

435 440 445

Phe?Gly?Ala?Pro?Ala?Tyr?Ala?Arg?Thr?Asp?Ala?Glu?Ala?Asn?Arg?Glu

450 455 460

Gln?Lys?Ala?Ile?Leu?Lys?Ala?Leu?Ser?Pro?Glu?Gln?Val?Thr?Ala?Thr

465 470 475 480

Glu?Leu?Ala?Gly?Glu?Ala?Ile?Thr?Ala?Lys?Leu?Thr?Glu?Ala?Pro?Gly

485 490 495

Asn?Gly?Ala?Ala?Ile?Gly?Gly?Leu?Lys?Val?Thr?Thr?Glu?Asn?Ala?Trp

500 505 510

Phe?Ala?Ala?Arg?Pro?Ser?Gly?Thr?Glu?Asp?Lys?Tyr?Lys?Ile?Tyr?Ala

515 520 525

Glu?Ser?Phe?Lys?Gly?Glu?Glu?His?Leu?Ala?Gln?Val?Gln?Lys?Glu?Ala

530 535 540

Gln?Ala?Leu?Val?Ser?Glu?Val?Leu?Gly?Gln

545 550

<210>27

<211>680

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(657)

<223>RXN02803

<400>27

gtc?tct?gga?gag?atg?ctc?gcg?gca?gca?ctt?tca?gca?ggc?atg?gcc?agc 48

Val?Ser?Gly?Glu?Met?Leu?Ala?Ala?Ala?Leu?Ser?Ala?Gly?Met?Ala?Ser

1 5 10 15

cag?ggt?gtt?gat?gtc?att?cgt?gtt?ggt?gtc?atc?cca?acc?cca?gct?gtt 96

Gln?Gly?Val?Asp?Val?Ile?Arg?Val?Gly?Val?Ile?Pro?Thr?Pro?Ala?Val

20 25 30

gca?ttc?ctc?acc?gat?gat?tat?ggc?gct?gac?atg?ggc?gtg?atg?att?tct 144

Ala?Phe?Leu?Thr?Asp?Asp?Tyr?Gly?Ala?Asp?Met?Gly?Val?Met?Ile?Ser

35 40 45

gca?tcc?cac?aac?cca?atg?ccg?gac?aac?gga?atc?aag?ttc?ttt?tct?gca 192

Ala?Ser?His?Asn?Pro?Met?Pro?Asp?Asn?Gly?Ile?Lys?Phe?Phe?Ser?Ala

50 55 60

ggt?gga?cac?aag?ctt?cca?gac?cat?gtg?gaa?gac?gag?att?gag?cgt?gtt 240

Gly?Gly?His?Lys?Leu?Pro?Asp?His?Val?Glu?Asp?Glu?Ile?Glu?Arg?Val

65 70 75 80

atg?gac?agc?ttg?cca?gca?gaa?ggc?cca?aca?ggg?cat?gga?gtt?ggc?cgt 288

Met?Asp?Ser?Leu?Pro?Ala?Glu?Gly?Pro?Thr?Gly?His?Gly?Val?Gly?Arg

85 90 95

gtc?atc?gaa?gaa?gca?acc?gat?gca?cag?gac?cgt?tac?cta?gag?cac?ctg 336

Val?Ile?Glu?Glu?Ala?Thr?Asp?Ala?Gln?Asp?Arg?Tyr?Leu?Glu?His?Leu

100 105 110

aag?gaa?gct?gtt?cct?acg?tca?ctt?gaa?ggc?atc?aag?att?gtt?gtg?gat 384

Lys?Glu?Ala?Val?Pro?Thr?Ser?Leu?Glu?Gly?Ile?Lys?Ile?Val?Val?Asp

115 120 125

gca?gcc?aat?ggt?gcg?gca?agt?gtt?gta?gct?cca?acg?gct?tat?gag?gct 432

Ala?Ala?Asn?Gly?Ala?Ala?Ser?Val?Val?Ala?Pro?Thr?Ala?Tyr?Glu?Ala

130 135 140

gcg?ggt?gca?act?gta?att?gct?att?cat?aac?aag?cca?gac?tca?tac?aac 480

Ala?Gly?Ala?Thr?Val?Ile?Ala?Ile?His?Asn?Lys?Pro?Asp?Ser?Tyr?Asn

145 150 155 160

atc?aac?atg?gac?tgc?ggt?tcc?acc?cac?att?gat?cag?gcg?cag?ccg?cca 528

Ile?Asn?Met?Asp?Cys?Gly?Ser?Thr?His?Ile?Asp?Gln?Ala?Gln?Pro?Pro

165 170 175

gtc?ttg?aag?cac?ggt?gct?gac?ctt?gga?ctc?gcg?cat?gac?ggt?gat?gct 576

Val?Leu?Lys?His?Gly?Ala?Asp?Leu?Gly?Leu?Ala?His?Asp?Gly?Asp?Ala

180 185 190

gac?cgt?tgt?ttg?gct?gtg?aac?aag?gat?gcc?aac?ctt?gtt?gat?ggt?gac 624

Asp?Arg?Cys?Leu?Ala?Val?Asn?Lys?Asp?Ala?Asn?Leu?Val?Asp?Gly?Asp

195 200 205

caa?atc?atg?gcg?ctg?tta?gcc?att?gcg?atg?aaa?taaaacggcg?agctgcgcaa?677

Gln?Ile?Met?Ala?Leu?Leu?Ala?Ile?Ala?Met?Lys

210 215

gaa 680

<210>28

<211>219

<212>PRT

＜213〉Corynebacterium glutamicum

<400>28

Val?Ser?Gly?Glu?Met?Leu?Ala?Ala?Ala?Leu?Ser?Ala?Gly?Met?Ala?Ser

1 5 10 15

Gln?Gly?Val?Asp?Val?Ile?Arg?Val?Gly?Val?Ile?Pro?Thr?Pro?Ala?Val

20 25 30

Ala?Phe?Leu?Thr?Asp?Asp?Tyr?Gly?Ala?Asp?Met?Gly?Val?Met?Ile?Ser

35 40 45

Ala?Ser?His?Asn?Pro?Met?Pro?Asp?Asn?Gly?Ile?Lys?Phe?Phe?Ser?Ala

50 55 60

Gly?Gly?His?Lys?Leu?Pro?Asp?His?Val?Glu?Asp?Glu?Ile?Glu?Arg?Val

65 70 75 80

Met?Asp?Ser?Leu?Pro?Ala?Glu?Gly?Pro?Thr?Gly?His?Gly?Val?Gly?Arg

85 90 95

Val?Ile?Glu?Glu?Ala?Thr?Asp?Ala?Gln?Asp?Arg?Tyr?Leu?Glu?His?Leu

100 105 110

Lys?Glu?Ala?Val?Pro?Thr?Ser?Leu?Glu?Gly?Ile?Lys?Ile?Val?Val?Asp

115 120 125

Ala?Ala?Asn?Gly?Ala?Ala?Ser?Val?Val?Ala?Pro?Thr?Ala?Tyr?Glu?Ala

130 135 140

Ala?Gly?Ala?Thr?Val?Ile?Ala?Ile?His?Asn?Lys?Pro?Asp?Ser?Tyr?Asn

145 150 155 160

Ile?Asn?Met?Asp?Cys?Gly?Ser?Thr?His?Ile?Asp?Gln?Ala?Gln?Pro?Pro

165 170 175

Val?Leu?Lys?His?Gly?Ala?Asp?Leu?Gly?Leu?Ala?His?Asp?Gly?Asp?Ala

180 185 190

Asp?Arg?Cys?Leu?Ala?Val?Asn?Lys?Asp?Ala?Asn?Leu?Val?Asp?Gly?Asp

195 200 205

Gln?Ile?Met?Ala?Leu?Leu?Ala?Ile?Ala?Met?Lys

210 215

<210>29

<211>399

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(399)

<223>FRXA02803

<400>29

tct?gga?gag?atg?ctc?gcg?gca?gca?ctt?tca?gca?ggc?atg?gcc?agc?cag 48

Ser?Gly?Glu?Met?Leu?Ala?Ala?Ala?Leu?Ser?Ala?Gly?Met?Ala?Ser?Gln

1 5 10 15

ggt?gtt?gat?gtc?att?cgt?gtt?ggt?gtc?atc?cca?acc?cca?gct?gtt?gca 96

Gly?Val?Asp?Val?Ile?Arg?Val?Gly?Val?Ile?Pro?Thr?Pro?Ala?Val?Ala

20 25 30

ttc?ctc?acc?gat?gat?tat?ggc?gct?gac?atg?ggc?gtg?atg?att?tct?gca 144

Phe?Leu?Thr?Asp?Asp?Tyr?Gly?Ala?Asp?Met?Gly?Val?Met?Ile?Ser?Ala

35 40 45

tcc?cac?aac?cca?atg?ccg?gac?aac?gga?atc?aag?ttc?ttt?tct?gca?ggt 192

Ser?His?Asn?Pro?Met?Pro?Asp?Asn?Gly?Ile?Lys?Phe?Phe?Ser?Ala?Gly

50 55 60

gga?cac?aag?ctt?cca?gac?cat?gtg?gaa?gac?gag?att?gag?cgt?gtt?atg 240

Gly?His?Lys?Leu?Pro?Asp?His?Val?Glu?Asp?Glu?Ile?Glu?Arg?Val?Met

65 70 75 80

gac?agc?ttg?cca?gca?gaa?ggc?cca?aca?ggg?cat?gga?gtt?ggc?cgt?gtc 288

Asp?Ser?Leu?Pro?Ala?Glu?Gly?Pro?Thr?Gly?His?Gly?Val?Gly?Arg?Val

85 90 95

atc?gaa?gaa?gca?acc?gat?gca?cag?gac?cgc?tac?cta?gag?cac?ctg?aag 336

Ile?Glu?Glu?Ala?Thr?Asp?Ala?Gln?Asp?Arg?Tyr?Leu?Glu?His?Leu?Lys

100 105 110

gaa?gct?gtt?cct?acg?tca?ctt?gaa?ggc?atc?aag?att?gtt?gtg?gat?gca 384

Glu?Ala?Val?Pro?Thr?Ser?Leu?Glu?Gly?Ile?Lys?Ile?Val?Val?Asp?Ala

115 120 125

gcc?aat?ggt?gcg?gca 399

Ala?Asn?Gly?Ala?Ala

130

<210>30

<211>133

<212>PRT

＜213〉Corynebacterium glutamicum

<400>30

Ser?Gly?Glu?Met?Leu?Ala?Ala?Ala?Leu?Ser?Ala?Gly?Met?Ala?Ser?Gln

1 5 10 15

Gly?Val?Asp?Val?Ile?Arg?Val?Gly?Val?Ile?Pro?Thr?Pro?Ala?Val?Ala

20 25 30

Phe?Leu?Thr?Asp?Asp?Tyr?Gly?Ala?Asp?Met?Gly?Val?Met?Ile?Ser?Ala

35 40 45

Ser?His?Asn?Pro?Met?Pro?Asp?Asn?Gly?Ile?Lys?Phe?Phe?Ser?Ala?Gly

50 55 60

Gly?His?Lys?Leu?Pro?Asp?His?Val?Glu?Asp?Glu?Ile?Glu?Arg?Val?Met

65 70 75 80

Asp?Ser?Leu?Pro?Ala?Glu?Gly?Pro?Thr?Gly?His?Gly?Val?Gly?Arg?Val

85 90 95

Ile?Glu?Glu?Ala?Thr?Asp?Ala?Gln?Asp?Arg?Tyr?Leu?Glu?His?Leu?Lys

100 105 110

Glu?Ala?Val?Pro?Thr?Ser?Leu?Glu?Gly?Ile?Lys?Ile?Val?Val?Asp?Ala

115 120 125

Ala?Asn?Gly?Ala?Ala

130

<210>31

<211>1713

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1690)

<223>RXN03076

<400>31

aatacctttc?tgttttgtcc?gcaggcgtat?caggaaaacc?tgcagcgcgg?tagagtcgag?60

tctaatagtg?atcccacgaa?aacaaaggat?cggggtgttc?atg?gac?gag?tct?cgt 115

Met?Asp?Glu?Ser?Arg

1 5

cag?ctt?agt?ttc?ggc?aca?gca?ggg?ttg?cgt?gca?cca?gtt?ggc?ccg?gcg 163

Gln?Leu?Ser?Phe?Gly?Thr?Ala?Gly?Leu?Arg?Ala?Pro?Val?Gly?Pro?Ala

10 15 20

cgc?cat?cag?atg?aat?gtt?ttg?cag?gta?acc?aga?act?aca?gca?ggt?gtt 211

Arg?His?Gln?Met?Asn?Val?Leu?Gln?Val?Thr?Arg?Thr?Thr?Ala?Gly?Val

25 30 35

gct?agt?tgg?ttg?gca?gaa?cgt?gcg?gca?cta?aat?cca?gtg?ccg?cat?ttg 259

Ala?Ser?Trp?Leu?Ala?Glu?Arg?Ala?Ala?Leu?Asn?Pro?Val?Pro?His?Leu

40 45 50

gtt?cct?gag?gat?gaa?aca?gga?atc?ggc?agg?gcg?ttg?tat?ccc?caa?gat 307

Val?Pro?Glu?Asp?Glu?Thr?Gly?Ile?Gly?Arg?Ala?Leu?Tyr?Pro?Gln?Asp

55 60 65

ggt?ccg?ttg?cgg?gtc?gtt?gtg?ggg?tat?gac?gct?cgc?tat?ggt?tcg?cat 355

Gly?Pro?Leu?Arg?Val?Val?Val?Gly?Tyr?Asp?Ala?Arg?Tyr?Gly?Ser?His

70 75 80 85

act?ttt?gct?gca?acc?act?gcg?gag?gtg?ttc?gcg?ggt?gct?ggt?ttt?gag 403

Thr?Phe?Ala?Ala?Thr?Thr?Ala?Glu?Val?Phe?Ala?Gly?Ala?Gly?Phe?Glu

90 95 100

gtg?acg?ttg?ctc?ccc?acg?cct?agc?cct?acg?ccg?ttg?att?ccg?tgg?ttg 451

Val?Thr?Leu?Leu?Pro?Thr?Pro?Ser?Pro?Thr?Pro?Leu?Ile?Pro?Trp?Leu

105 110 115

gtg?aac?aag?cat?ggg?ttg?gat?gcg?ggc?gtt?cag?atc?acg?gct?tcg?cat 499

Val?Asn?Lys?His?Gly?Leu?Asp?Ala?Gly?Val?Gln?Ile?Thr?Ala?Ser?His

120 125 130

aat?ggt?gcg?gcg?gac?aat?ggc?tac?aag?gtg?ttt?ttg?tct?aat?ggt?cgc 547

Asn?Gly?Ala?Ala?Asp?Asn?Gly?Tyr?Lys?Val?Phe?Leu?Ser?Asn?Gly?Arg

135 140 145

cag?ctt?tat?tct?gaa?ctg?gag?cct?gag?ctt?gag?gcg?cat?atc?aat?gct 595

Gln?Leu?Tyr?Ser?Glu?Leu?Glu?Pro?Glu?Leu?Glu?Ala?His?Ile?Asn?Ala

150 155 160 165

gtg?gaa?gat?ccg?att?cgg?gtt?cct?cgg?gtg?acg?gtg?cgc?ccc?act?gct 643

Val?Glu?Asp?Pro?Ile?Arg?Val?Pro?Arg?Val?Thr?Val?Arg?Pro?Thr?Ala

170 175 180

gat?cag?ctg?cgt?cga?tat?gtt?gat?gag?atg?gtg?tcg?ttg?gtg?act?cct 691

Asp?Gln?Leu?Arg?Arg?Tyr?Val?Asp?Glu?Met?Val?Ser?Leu?Val?Thr?Pro

185 190 195

gat?cag?gct?gat?ttg?ttg?cgg?gtg?aat?tct?gag?cgg?ggc?aat?ctt?cgc 739

Asp?Gln?Ala?Asp?Leu?Leu?Arg?Val?Asn?Ser?Glu?Arg?Gly?Asn?Leu?Arg

200 205 210

gtg?gtg?tat?acc?gct?ctg?cat?ggt?gtg?ggt?ggc?cgc?gcg?atg?gcc?aat 787

Val?Val?Tyr?Thr?Ala?Leu?His?Gly?Val?Gly?Gly?Arg?Ala?Met?Ala?Asn

215 220 225

gct?ttc?caa?ttt?gct?ggt?ttt?ccc?cat?act?cat?ggc?gtg?aag?gct?cag 835

Ala?Phe?Gln?Phe?Ala?Gly?Phe?Pro?His?Thr?His?Gly?Val?Lys?Ala?Gln

230 235 240 245

cag?tat?cct?gat?ccc?acc?ttc?ccc?act?gtg?gcg?ttc?ccc?aat?ccg?gaa 883

Gln?Tyr?Pro?Asp?Pro?Thr?Phe?Pro?Thr?Val?Ala?Phe?Pro?Asn?Pro?Glu

250 255 260

gag?cct?tct?gcg?att?gag?ttg?ttg?ttg?gaa?cgc?gca?aag?gaa?aag?aac 931

Glu?Pro?Ser?Ala?Ile?Glu?Leu?Leu?Leu?Glu?Arg?Ala?Lys?Glu?Lys?Asn

265 270 275

gct?gac?att?ttg?ttt?gcg?ctt?gat?cct?gat?gcc?gat?cgt?tgt?gct?gtg 979

Ala?Asp?Ile?Leu?Phe?Ala?Leu?Asp?Pro?Asp?Ala?Asp?Arg?Cys?Ala?Val

280 285 290

ggt?att?cgt?acc?gct?gat?ggc?ggc?cac?cga?atg?ctc?tct?ggc?gat?gag 1027

Gly?Ile?Arg?Thr?Ala?Asp?Gly?Gly?His?Arg?Met?Leu?Ser?Gly?Asp?Glu

295 300 305

gtg?ggc?aca?ctt?ttg?gct?act?cgt?ttg?gtt?ccg?gag?tat?tcc?ggt?gaa 1075

Val?Gly?Thr?Leu?Leu?Ala?Thr?Arg?Leu?Val?Pro?Glu?Tyr?Ser?Gly?Glu

310 315 320 325

ggc?cca?cgt?ccc?gtg?gtt?gcc?acc?acg?gtg?gtg?tct?tcg?cag?ctt?ctg 1123

Gly?Pro?Arg?Pro?Val?Val?Ala?Thr?Thr?Val?Val?Ser?Ser?Gln?Leu?Leu

330 335 340

ggt?atc?atc?gcc?gag?gat?aaa?ggg?tgg?gat?tat?tcc?gag?aca?ctg?acg 1171

Gly?Ile?Ile?Ala?Glu?Asp?Lys?Gly?Trp?Asp?Tyr?Ser?Glu?Thr?Leu?Thr

345 350 355

gga?ttc?aaa?aat?ctg?tcg?agg?gct?gcc?gat?ggt?ctc?gac?gga?ccg?ctt 1219

Gly?Phe?Lys?Asn?Leu?Ser?Arg?Ala?Ala?Asp?Gly?Leu?Asp?Gly?Pro?Leu

360 365 370

gct?ttc?gct?tat?gag?gaa?gct?gtg?ggc?acc?tgc?ccg?gtt?cca?gat?gtc 1267

Ala?Phe?Ala?Tyr?Glu?Glu?Ala?Val?Gly?Thr?Cys?Pro?Val?Pro?Asp?Val

375 380 385

gtg?ccg?gat?aag?gac?ggc?atc?tct?aca?gcg?ttg?ttc?atg?gcg?tcg?tgg 1315

Val?Pro?Asp?Lys?Asp?Gly?Ile?Ser?Thr?Ala?Leu?Phe?Met?Ala?Ser?Trp

390 395 400 405

gct?gcc?gaa?ctg?aag?gct?cag?ggc?gca?agc?ctg?cag?caa?aaa?ctc?aat 1363

Ala?Ala?Glu?Leu?Lys?Ala?Gln?Gly?Ala?Ser?Leu?Gln?Gln?Lys?Leu?Asn

410 415 420

gag?ttg?tat?cgc?cga?tat?ggg?tat?ttt?gcg?tcc?tcg?caa?att?gct?gtg 1411

Glu?Leu?Tyr?Arg?Arg?Tyr?Gly?Tyr?Phe?Ala?Ser?Ser?Gln?Ile?Ala?Val

425 430 435

cgc?acg?agc?agt?cca?cgc?gag?tta?gtt?gat?cac?tgg?att?gcg?cat?cct 1459

Arg?Thr?Ser?Ser?Pro?Arg?Glu?Leu?Val?Asp?His?Trp?Ile?Ala?His?Pro

440 445 450

cag?caa?gaa?ctc?att?gga?gtg?tct?gtc?acc?cca?cat?att?ctt?cct?gaa 1507

Gln?Gln?Glu?Leu?Ile?Gly?Val?Ser?Val?Thr?Pro?His?Ile?Leu?Pro?Glu

455 460 465

aaa?cag?ggc?att?gct?ttg?cat?ggc?cag?gtg?ggg?cat?gtg?cat?atc?cgt 1555

Lys?Gln?Gly?Ile?Ala?Leu?His?Gly?Gln?Val?Gly?His?Val?His?Ile?Arg

470 475 480 485

gct?att?ggt?cga?gtc?tct?gga?act?gag?gcg?aaa?gcc?aag?ctc?tat?ttg 1603

Ala?Ile?Gly?Arg?Val?Ser?Gly?Thr?Glu?Ala?Lys?Ala?Lys?Leu?Tyr?Leu

490 495 500

gaa?gtt?ggt?cag?gcc?agc?tcc?cat?gat?gaa?gca?gct?cag?ttg?ttg?cat 1651

Glu?Val?Gly?Gln?Ala?Ser?Ser?His?Asp?Glu?Ala?Ala?Gln?Leu?Leu?His

505 510 515

cag?ctg?gag?gat?gaa?gtc?caa?agc?tgg?ttg?agc?aag?ctt?tagtttcctg 1700

Gln?Leu?Glu?Asp?Glu?Val?Gln?Ser?Trp?Leu?Ser?Lys?Leu

520 525 530

gctgctcccg?gtt 1713

<210>32

<211>530

<212>PRT

＜213〉Corynebacterium glutamicum

<400>32

Met?Asp?Glu?Ser?Arg?Gln?Leu?Ser?Phe?Gly?Thr?Ala?Gly?Leu?Arg?Ala

1 5 10 15

Pro?Val?Gly?Pro?Ala?Arg?His?Gln?Met?Asn?Val?Leu?Gln?Val?Thr?Arg

20 25 30

Thr?Thr?Ala?Gly?Val?Ala?Ser?Trp?Leu?Ala?Glu?Arg?Ala?Ala?Leu?Asn

35 40 45

Pro?Val?Pro?His?Leu?Val?Pro?Glu?Asp?Glu?Thr?Gly?Ile?Gly?Arg?Ala

50 55 60

Leu?Tyr?Pro?Gln?Asp?Gly?Pro?Leu?Arg?Val?Val?Val?Gly?Tyr?Asp?Ala

65 70 75 80

Arg?Tyr?Gly?Ser?His?Thr?Phe?Ala?Ala?Thr?Thr?Ala?Glu?Val?Phe?Ala

85 90 95

Gly?Ala?Gly?Phe?Glu?Val?Thr?Leu?Leu?Pro?Thr?Pro?Ser?Pro?Thr?Pro

100 105 110

Leu?Ile?Pro?Trp?Leu?Val?Asn?Lys?His?Gly?Leu?Asp?Ala?Gly?Val?Gln

115 120 125

Ile?Thr?Ala?Ser?His?Asn?Gly?Ala?Ala?Asp?Asn?Gly?Tyr?Lys?Val?Phe

130 135 140

Leu?Ser?Asn?Gly?Arg?Gln?Leu?Tyr?Ser?Glu?Leu?Glu?Pro?Glu?Leu?Glu

145 150 155 160

Ala?His?Ile?Asn?Ala?Val?Glu?Asp?Pro?Ile?Arg?Val?Pro?Arg?Val?Thr

165 170 175

Val?Arg?Pro?Thr?Ala?Asp?Gln?Leu?Arg?Arg?Tyr?Val?Asp?Glu?Met?Val

180 185 190

Ser?Leu?Val?Thr?Pro?Asp?Gln?Ala?Asp?Leu?Leu?Arg?Val?Asn?Ser?Glu

195 200 205

Arg?Gly?Asn?Leu?Arg?Val?Val?Tyr?Thr?Ala?Leu?His?Gly?Val?Gly?Gly

210 215 220

Arg?Ala?Met?Ala?Asn?Ala?Phe?Gln?Phe?Ala?Gly?Phe?Pro?His?Thr?His

225 230 235 240

Gly?Val?Lys?Ala?Gln?Gln?Tyr?Pro?Asp?Pro?Thr?Phe?Pro?Thr?Val?Ala

245 250 255

Phe?Pro?Asn?Pro?Glu?Glu?Pro?Ser?Ala?Ile?Glu?Leu?Leu?Leu?Glu?Arg

260 265 270

Ala?Lys?Glu?Lys?Asn?Ala?Asp?Ile?Leu?Phe?Ala?Leu?Asp?Pro?Asp?Ala

275 280 285

Asp?Arg?Cys?Ala?Val?Gly?Ile?Arg?Thr?Ala?Asp?Gly?Gly?His?Arg?Met

290 295 300

Leu?Ser?Gly?Asp?Glu?Val?Gly?Thr?Leu?Leu?Ala?Thr?Arg?Leu?Val?Pro

305 310 315 320

Glu?Tyr?Ser?Gly?Glu?Gly?Pro?Arg?Pro?Val?Val?Ala?Thr?Thr?Val?Val

325 330 335

Ser?Ser?Gln?Leu?Leu?Gly?Ile?Ile?Ala?Glu?Asp?Lys?Gly?Trp?Asp?Tyr

340 345 350

Ser?Glu?Thr?Leu?Thr?Gly?Phe?Lys?Asn?Leu?Ser?Arg?Ala?Ala?Asp?Gly

355 360 365

Leu?Asp?Gly?Pro?Leu?Ala?Phe?Ala?Tyr?Glu?Glu?Ala?Val?Gly?Thr?Cys

370 375 380

Pro?Val?Pro?Asp?Val?Val?Pro?Asp?Lys?Asp?Gly?Ile?Ser?Thr?Ala?Leu

385 390 395 400

Phe?Met?Ala?Ser?Trp?Ala?Ala?Glu?Leu?Lys?Ala?Gln?Gly?Ala?Ser?Leu

405 410 415

Gln?Gln?Lys?Leu?Asn?Glu?Leu?Tyr?Arg?Arg?Tyr?Gly?Tyr?Phe?Ala?Ser

420 425 430

Ser?Gln?Ile?Ala?Val?Arg?Thr?Ser?Ser?Pro?Arg?Glu?Leu?Val?Asp?His

435 440 445

Trp?Ile?Ala?His?Pro?Gln?Gln?Glu?Leu?Ile?Gly?Val?Ser?Val?Thr?Pro

450 455 460

His?Ile?Leu?Pro?Glu?Lys?Gln?Gly?Ile?Ala?Leu?His?Gly?Gln?Val?Gly

465 470 475 480

His?Val?His?Ile?Arg?Ala?Ile?Gly?Arg?Val?Ser?Gly?Thr?Glu?Ala?Lys

485 490 495

Ala?Lys?Leu?Tyr?Leu?Glu?Val?Gly?Gln?Ala?Ser?Ser?His?Asp?Glu?Ala

500 505 510

Ala?Gln?Leu?Leu?His?Gln?Leu?Glu?Asp?Glu?Val?Gln?Ser?Trp?Leu?Ser

515 520 525

Lys?Leu

530

<210>33

<211>1684

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1684)

<223>FRXA02854

<400>33

aatacctttc?tgttttgtcc?gcaggcgtat?caggaaaacc?tgcagcgcgg?tagagtcgag?60

tctaatagtg?atcccacgaa?aacaaaggat?cggggtgttc?atg?gac?gag?tct?cgt 115

Met?Asp?Glu?Ser?Arg

1 5

cag?ctt?agt?ttc?ggc?aca?gca?ggg?ttg?cgt?gca?cca?gtt?ggc?ccg?gcg 163

Gln?Leu?Ser?Phe?Gly?Thr?Ala?Gly?Leu?Arg?Ala?Pro?Val?Gly?Pro?Ala

10 15 20

cgc?cat?cag?atg?aat?gtt?ttg?cag?gta?acc?aga?act?aca?gca?ggt?gtt 211

Arg?His?Gln?Met?Asn?Val?Leu?Gln?Val?Thr?Arg?Thr?Thr?Ala?Gly?Val

25 30 35

gct?agt?tgg?ttg?gca?gaa?cgt?gcg?gca?cta?aat?cca?gtg?ccg?cat?ttg 259

Ala?Ser?Trp?Leu?Ala?Glu?Arg?Ala?Ala?Leu?Asn?Pro?Val?Pro?His?Leu

40 45 50

gtt?cct?gag?gat?gaa?aca?gga?atc?ggc?agg?gcg?ttg?tat?ccc?caa?gat 307

Val?Pro?Glu?Asp?Glu?Thr?Gly?Ile?Gly?Arg?Ala?Leu?Tyr?Pro?Gln?Asp

55 60 65

ggt?ccg?ttg?cgg?gtc?gtt?gtg?ggg?tat?gac?gct?cgc?tat?ggt?tcg?cat 355

Gly?Pro?Leu?Arg?Val?Val?Val?Gly?Tyr?Asp?Ala?Arg?Tyr?Gly?Ser?His

70 75 80 85

act?ttt?gct?gca?acc?act?gcg?gag?gtg?ttc?gcg?ggt?gct?ggt?ttt?gag 403

Thr?Phe?Ala?Ala?Thr?Thr?Ala?Glu?Val?Phe?Ala?Gly?Ala?Gly?Phe?Glu

90 95 100

gtg?acg?ttg?ctc?ccc?acg?cct?agc?cct?acg?ccg?ttg?att?ccg?tgg?ttg 451

Val?Thr?Leu?Leu?Pro?Thr?Pro?Ser?Pro?Thr?Pro?Leu?Ile?Pro?Trp?Leu

105 110 115

gtg?aac?aag?cat?ggg?ttg?gat?gcg?ggc?gtt?cag?atc?acg?gct?tcg?cat 499

Val?Asn?Lys?His?Gly?Leu?Asp?Ala?Gly?Val?Gln?Ile?Thr?Ala?Ser?His

120 125 130

aat?ggt?gcg?gcg?gac?aat?ggc?tac?aag?gtg?ttt?ttg?tct?aat?ggt?cgc 547

Asn?Gly?Ala?Ala?Asp?Asn?Gly?Tyr?Lys?Val?Phe?Leu?Ser?Asn?Gly?Arg

135 140 145

cag?ctt?tat?tct?gaa?ctg?gag?cct?gag?ctt?gag?gcg?cat?atc?aat?gct 595

Gln?Leu?Tyr?Ser?Glu?Leu?Glu?Pro?Glu?Leu?Glu?Ala?His?Ile?Asn?Ala

150 155 160 165

gtg?gaa?gat?ccg?att?cgg?gtt?cct?cgg?gtg?acg?gtg?cgc?ccc?act?gct 643

Val?Glu?Asp?Pro?Ile?Arg?Val?Pro?Arg?Val?Thr?Val?Arg?Pro?Thr?Ala

170 175 180

gat?cag?ctg?cgt?cga?tat?gtt?gat?gag?atg?gtg?tcg?ttg?gtg?act?cct 691

Asp?Gln?Leu?Arg?Arg?Tyr?Val?Asp?Glu?Met?Val?Ser?Leu?Val?Thr?Pro

185 190 195

gat?cag?gct?gat?ttg?ttg?cgg?gtg?aat?tct?gag?cgg?ggc?aat?ctt?cgc 739

Asp?Gln?Ala?Asp?Leu?Leu?Arg?Val?Asn?Ser?Glu?Arg?Gly?Asn?Leu?Arg

200 205 210

gtg?gtg?tat?acc?gct?ctg?cat?ggt?gtg?ggt?ggc?cgc?gcg?atg?gcc?aat 787

Val?Val?Tyr?Thr?Ala?Leu?His?Gly?Val?Gly?Gly?Arg?Ala?Met?Ala?Asn

215 220 225

gct?ttc?caa?ttt?gct?ggt?ttt?ccc?cat?act?cat?ggc?gtg?aag?gct?cag 835

Ala?Phe?Gln?Phe?Ala?Gly?Phe?Pro?His?Thr?His?Gly?Val?Lys?Ala?Gln

230 235 240 245

cag?tat?cct?gat?ccc?acc?ttc?ccc?act?gtg?gcg?ttc?ccc?aat?ccg?gaa 883

Gln?Tyr?Pro?Asp?Pro?Thr?Phe?Pro?Thr?Val?Ala?Phe?Pro?Asn?Pro?Glu

250 255 260

gag?cct?tct?gcg?att?gag?ttg?ttg?ttg?gaa?cgc?gca?aag?gaa?aag?aac 931

Glu?Pro?Ser?Ala?Ile?Glu?Leu?Leu?Leu?Glu?Arg?Ala?Lys?Glu?Lys?Asn

265 270 275

gct?gac?att?ttg?ttt?gcg?ctt?gat?cct?gat?gcc?gat?cgt?tgt?gct?gtg 979

Ala?Asp?Ile?Leu?Phe?Ala?Leu?Asp?Pro?Asp?Ala?Asp?Arg?Cys?Ala?Val

280 285 290

ggt?att?cgt?acc?gct?gat?ggc?ggc?cac?cga?atg?ctc?tct?ggc?gat?gag 1027

Gly?Ile?Arg?Thr?Ala?Asp?Gly?Gly?His?Arg?Met?Leu?Ser?Gly?Asp?Glu

295 300 305

gtg?ggc?aca?ctt?ttg?gct?act?cgt?ttg?gtt?ccg?gag?tat?tcc?ggt?gaa 1075

Val?Gly?Thr?Leu?Leu?Ala?Thr?Arg?Leu?Val?Pro?Glu?Tyr?Ser?Gly?Glu

310 315 320 325

ggc?cca?cgt?ccc?gtg?gtt?gcc?acc?acg?gtg?gtg?tct?tcg?cag?ctt?ctg 1123

Gly?Pro?Arg?Pro?Val?Val?Ala?Thr?Thr?Val?Val?Ser?Ser?Gln?Leu?Leu

330 335 340

ggt?atc?atc?gcc?gag?gat?aaa?ggg?tgg?gat?tat?tcc?gag?aca?ctg?acg 1171

Gly?Ile?Ile?Ala?Glu?Asp?Lys?Gly?Trp?Asp?Tyr?Ser?Glu?Thr?Leu?Thr

345 350 355

gga?ttc?aaa?aat?ctg?tcg?agg?gct?gcc?gat?ggt?ctc?gac?gga?ccg?ctt 1219

Gly?Phe?Lys?Asn?Leu?Ser?Arg?Ala?Ala?Asp?Gly?Leu?Asp?Gly?Pro?Leu

360 365 370

gct?ttc?gct?tat?gag?gaa?gct?gtg?ggc?acc?tgc?ccg?gtt?cca?gat?gtc 1267

Ala?Phe?Ala?Tyr?Glu?Glu?Ala?Val?Gly?Thr?Cys?Pro?Val?Pro?Asp?Val

375 380 385

gtg?ccg?gat?aag?gac?ggc?atc?tct?aca?gcg?ttg?ttc?atg?gcg?tcg?tgg 1315

Val?Pro?Asp?Lys?Asp?Gly?Ile?Ser?Thr?Ala?Leu?Phe?Met?Ala?Ser?Trp

390 395 400 405

gct?gcc?gaa?ctg?aag?gct?cag?ggc?gca?agc?ctg?cag?caa?aaa?ctc?aat 1363

Ala?Ala?Glu?Leu?Lys?Ala?Gln?Gly?Ala?Ser?Leu?Gln?Gln?Lys?Leu?Asn

410 415 420

gag?ttg?tat?cgc?cga?tat?ggg?tat?ttt?gcg?tcc?tcg?caa?att?gct?gtg 1411

Glu?Leu?Tyr?Arg?Arg?Tyr?Gly?Tyr?Phe?Ala?Ser?Ser?Gln?Ile?Ala?Val

425 430 435

cgc?acg?agc?agt?cca?cgc?gag?tta?gtt?gat?cac?tgg?att?gcg?cat?cct 1459

Arg?Thr?Ser?Ser?Pro?Arg?Glu?Leu?Val?Asp?His?Trp?Ile?Ala?His?Pro

440 445 450

cag?caa?gaa?ctc?att?gga?gtg?tct?gtc?acc?cca?cat?att?ctt?cct?gaa 1507

Gln?Gln?Glu?Leu?Ile?Gly?Val?Ser?Val?Thr?Pro?His?Ile?Leu?Pro?Glu

455 460 465

aaa?cag?ggc?att?gct?ttg?cat?ggc?cag?gtg?ggg?cat?gtg?cat?atc?cgt 1555

Lys?Gln?Gly?Ile?Ala?Leu?His?Gly?Gln?Val?Gly?His?Val?His?Ile?Arg

470 475 480 485

gct?att?ggt?cga?gtc?tct?gga?act?gag?gcg?aaa?gcc?aag?ctc?tat?ttg 1603

Ala?Ile?Gly?Arg?Val?Ser?Gly?Thr?Glu?Ala?Lys?Ala?Lys?Leu?Tyr?Leu

490 495 500

gaa?gtt?ggt?cag?gcc?agc?tcc?cat?gat?gaa?gca?gct?cag?ttg?ttg?cat 1651

Glu?Val?Gly?Gln?Ala?Ser?Ser?His?Asp?Glu?Ala?Ala?Gln?Leu?Leu?His

505 510 515

cag?ctg?gag?gat?gaa?gtc?caa?agc?tgg?ttg?agc 1684

Gln?Leu?Glu?Asp?Glu?Val?Gln?Ser?Trp?Leu?Ser

520 525

<210>34

<211>528

<212>PRT

＜213〉Corynebacterium glutamicum

<400>34

Met?Asp?Glu?Ser?Arg?Gln?Leu?Ser?Phe?Gly?Thr?Ala?Gly?Leu?Arg?Ala

1 5 10 15

Pro?Val?Gly?Pro?Ala?Arg?His?Gln?Met?Asn?Val?Leu?Gln?Val?Thr?Arg

20 25 30

Thr?Thr?Ala?Gly?Val?Ala?Ser?Trp?Leu?Ala?Glu?Arg?Ala?Ala?Leu?Asn

35 40 45

Pro?Val?Pro?His?Leu?Val?Pro?Glu?Asp?Glu?Thr?Gly?Ile?Gly?Arg?Ala

50 55 60

Leu?Tyr?Pro?Gln?Asp?Gly?Pro?Leu?Arg?Val?Val?Val?Gly?Tyr?Asp?Ala

65 70 75 80

Arg?Tyr?Gly?Ser?His?Thr?Phe?Ala?Ala?Thr?Thr?Ala?Glu?Val?Phe?Ala

85 90 95

Gly?Ala?Gly?Phe?Glu?Val?Thr?Leu?Leu?Pro?Thr?Pro?Ser?Pro?Thr?Pro

100 105 110

Leu?Ile?Pro?Trp?Leu?Val?Asn?Lys?His?Gly?Leu?Asp?Ala?Gly?Val?Gln

115 120 125

Ile?Thr?Ala?Ser?His?Asn?Gly?Ala?Ala?Asp?Asn?Gly?Tyr?Lys?Val?Phe

130 135 140

Leu?Ser?Asn?Gly?Arg?Gln?Leu?Tyr?Ser?Glu?Leu?Glu?Pro?Glu?Leu?Glu

145 150 155 160

Ala?His?Ile?Asn?Ala?Val?Glu?Asp?Pro?Ile?Arg?Val?Pro?Arg?Val?Thr

165 170 175

Val?Arg?Pro?Thr?Ala?Asp?Gln?Leu?Arg?Arg?Tyr?Val?Asp?Glu?Met?Val

180 185 190

Ser?Leu?Val?Thr?Pro?Asp?Gln?Ala?Asp?Leu?Leu?Arg?Val?Asn?Ser?Glu

195 200 205

Arg?Gly?Asn?Leu?Arg?Val?Val?Tyr?Thr?Ala?Leu?His?Gly?Val?Gly?Gly

210 215 220

Arg?Ala?Met?Ala?Asn?Ala?Phe?Gln?Phe?Ala?Gly?Phe?Pro?His?Thr?His

225 230 235 240

Gly?Val?Lys?Ala?Gln?Gln?Tyr?Pro?Asp?Pro?Thr?Phe?Pro?Thr?Val?Ala

245 250 255

Phe?Pro?Asn?Pro?Glu?Glu?Pro?Ser?Ala?Ile?Glu?Leu?Leu?Leu?Glu?Arg

260 265 270

Ala?Lys?Glu?Lys?Asn?Ala?Asp?Ile?Leu?Phe?Ala?Leu?Asp?Pro?Asp?Ala

275 280 285

Asp?Arg?Cys?Ala?Val?Gly?Ile?Arg?Thr?Ala?Asp?Gly?Gly?His?Arg?Met

290 295 300

Leu?Ser?Gly?Asp?Glu?Val?Gly?Thr?Leu?Leu?Ala?Thr?Arg?Leu?Val?Pro

305 310 315 320

Glu?Tyr?Ser?Gly?Glu?Gly?Pro?Arg?Pro?Val?Val?Ala?Thr?Thr?Val?Val

325 330 335

Ser?Ser?Gln?Leu?Leu?Gly?Ile?Ile?Ala?Glu?Asp?Lys?Gly?Trp?Asp?Tyr

340 345 350

Ser?Glu?Thr?Leu?Thr?Gly?Phe?Lys?Asn?Leu?Ser?Arg?Ala?Ala?Asp?Gly

355 360 365

Leu?Asp?Gly?Pro?Leu?Ala?Phe?Ala?Tyr?Glu?Glu?Ala?Val?Gly?Thr?Cys

370 375 380

Pro?Val?Pro?Asp?Val?Val?Pro?Asp?Lys?Asp?Gly?Ile?Ser?Thr?Ala?Leu

385 390 395 400

Phe?Met?Ala?Ser?Trp?Ala?Ala?Glu?Leu?Lys?Ala?Gln?Gly?Ala?Ser?Leu

405 410 415

Gln?Gln?Lys?Leu?Asn?Glu?Leu?Tyr?Arg?Arg?Tyr?Gly?Tyr?Phe?Ala?Ser

420 425 430

Ser?Gln?Ile?Ala?Val?Arg?Thr?Ser?Ser?Pro?Arg?Glu?Leu?Val?Asp?His

435 440 445

Trp?Ile?Ala?His?Pro?Gln?Gln?Glu?Leu?Ile?Gly?Val?Ser?Val?Thr?Pro

450 455 460

His?Ile?Leu?Pro?Glu?Lys?Gln?Gly?Ile?Ala?Leu?His?Gly?Gln?Val?Gly

465 470 475 480

His?Val?His?Ile?Arg?Ala?Ile?Gly?Arg?Val?Ser?Gly?Thr?Glu?Ala?Lys

485 490 495

Ala?Lys?Leu?Tyr?Leu?Glu?Val?Gly?Gln?Ala?Ser?Ser?His?Asp?Glu?Ala

500 505 510

Ala?Gln?Leu?Leu?His?Gln?Leu?Glu?Asp?Glu?Val?Gln?Ser?Trp?Leu?Ser

515 520 525

<210>35

<211>536

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(513)

<223>RXA00511

<400>35

gag?ctg?cgc?aag?aac?acc?ctc?gtg?ggc?act?gtc?atg?agc?aac?ctg?gga 48

Glu?Leu?Arg?Lys?Asn?Thr?Leu?Val?Gly?Thr?Val?Met?Ser?Asn?Leu?Gly

1 5 10 15

ttg?aag?att?gct?atg?gat?gaa?gcc?gga?att?aca?ctg?cgt?acc?acc?aag 96

Leu?Lys?Ile?Ala?Met?Asp?Glu?Ala?Gly?Ile?Thr?Leu?Arg?Thr?Thr?Lys

20 25 30

gta?gga?gac?cgc?tac?gtg?ctg?gaa?gac?ctc?aat?gca?ggt?gga?ttc?agc 144

Val?Gly?Asp?Arg?Tyr?Val?Leu?Glu?Asp?Leu?Asn?Ala?Gly?Gly?Phe?Ser

35 40 45

ctg?ggc?ggc?gag?caa?tct?ggc?cac?att?gtt?ctt?cca?gat?cat?ggc?acc 192

Leu?Gly?Gly?Glu?Gln?Ser?Gly?His?Ile?Val?Leu?Pro?Asp?His?Gly?Thr

50 55 60

act?ggc?gat?gga?act?ttg?act?ggt?ctt?tcc?atc?atg?gcg?cgc?atg?gct 240

Thr?Gly?Asp?Gly?Thr?Leu?Thr?Gly?Leu?Ser?Ile?Met?Ala?Arg?Met?Ala

65 70 75 80

gaa?acc?gga?aag?tcc?ttg?ggc?gag?ttg?gca?caa?gct?atg?acg?gtg?ctg 288

Glu?Thr?Gly?Lys?Ser?Leu?Gly?Glu?Leu?Ala?Gln?Ala?Met?Thr?Val?Leu

85 90 95

cca?cag?gtt?ctg?atc?aat?gtg?cca?gtt?tcg?gat?aag?tcc?acc?atc?gtg 336

Pro?Gln?Val?Leu?Ile?Asn?Val?Pro?Val?Ser?Asp?Lys?Ser?Thr?Ile?Val

100 105 110

agc?cac?cca?agc?gtt?gtg?gct?gcg?atc?gcg?gaa?gca?gaa?gct?gag?ttg 384

Ser?His?Pro?Ser?Val?Val?Ala?Ala?Ile?Ala?Glu?Ala?Glu?Ala?Glu?Leu

115 120 125

ggc?gcc?acc?ggt?cgc?gtt?ctt?ctt?cgt?gct?tct?ggc?acc?gaa?gag?ctt 432

Gly?Ala?Thr?Gly?Arg?Val?Leu?Leu?Arg?Ala?Ser?Gly?Thr?Glu?Glu?Leu

130 135 140

ttc?cgc?gtg?atg?gtt?gag?gct?gga?gac?aag?gaa?caa?gct?cgt?cgt?atc 480

Phe?Arg?Val?Met?Val?Glu?Ala?Gly?Asp?Lys?Glu?Gln?Ala?Arg?Arg?Ile

145 150 155 160

gcg?gga?cgt?ctt?gct?gca?gtg?gtt?gca?gaa?gtc?taattcactt?cagtcacagc?533

Ala?Gly?Arg?Leu?Ala?Ala?Val?Val?Ala?Glu?Val

165 170

gca 536

<210>36

<211>171

<212>PRT

＜213〉Corynebacterium glutamicum

<400>36

Glu?Leu?Arg?Lys?Asn?Thr?Leu?Val?Gly?Thr?Val?Met?Ser?Asn?Leu?Gly

1 5 10 15

Leu?Lys?Ile?Ala?Met?Asp?Glu?Ala?Gly?Ile?Thr?Leu?Arg?Thr?Thr?Lys

20 25 30

Val?Gly?Asp?Arg?Tyr?Val?Leu?Glu?Asp?Leu?Asn?Ala?Gly?Gly?Phe?Ser

35 40 45

Leu?Gly?Gly?Glu?Gln?Ser?Gly?His?Ile?Val?Leu?Pro?Asp?His?Gly?Thr

50 55 60

Thr?Gly?Asp?Gly?Thr?Leu?Thr?Gly?Leu?Ser?Ile?Met?Ala?Arg?Met?Ala

65 70 75 80

Glu?Thr?Gly?Lys?Ser?Leu?Gly?Glu?Leu?Ala?Gln?Ala?Met?Thr?Val?Leu

85 90 95

Pro?Gln?Val?Leu?Ile?Asn?Val?Pro?Val?Ser?Asp?Lys?Ser?Thr?Ile?Val

100 105 110

Ser?His?Pro?Ser?Val?Val?Ala?Ala?Ile?Ala?Glu?Ala?Glu?Ala?Glu?Leu

115 120 125

Gly?Ala?Thr?Gly?Arg?Val?Leu?Leu?Arg?Ala?Ser?Gly?Thr?Glu?Glu?Leu

130 135 140

Phe?Arg?Val?Met?Val?Glu?Ala?Gly?Asp?Lys?Glu?Gln?Ala?Arg?Arg?Ile

145 150 155 160

Ala?Gly?Arg?Leu?Ala?Ala?Val?Val?Ala?Glu?Val

165 170

<210>37

<211>1497

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1474)

<223>RXN01365

<400>37

cctgatcagg?acgaatcata?aggtttgcta?ttcggattgg?atcctttggc?aggggtagga?60

ttgcaagcgt?tattttgttc?cctaacccct?tcgaggattt?atg?cgt?acc?cgt?gaa 115

Met?Arg?Thr?Arg?Glu

1 5

tct?gtc?aca?gct?gta?att?aag?gcg?tat?gac?gtc?cgt?ggt?gtt?gtt?ggt 163

Ser?Val?Thr?Ala?Val?Ile?Lys?Ala?Tyr?Asp?Val?Arg?Gly?Val?Val?Gly

10 15 20

gtc?gat?att?gat?gct?gat?ttc?att?tct?gag?act?ggc?gct?gcc?ttt?ggt 211

Val?Asp?Ile?Asp?Ala?Asp?Phe?Ile?Ser?Glu?Thr?Gly?Ala?Ala?Phe?Gly

25 30 35

cgg?ctc?atg?cgt?agt?gag?ggt?gaa?acc?acc?gtt?gct?att?ggc?cat?gac 259

Arg?Leu?Met?Arg?Ser?Glu?Gly?Glu?Thr?Thr?Val?Ala?Ile?Gly?His?Asp

40 45 50

atg?cgt?gat?tcc?tcc?cct?gaa?ttg?gcc?aag?gcg?ttt?gcc?gat?ggc?gtg 307

Met?Arg?Asp?Ser?Ser?Pro?Glu?Leu?Ala?Lys?Ala?Phe?Ala?Asp?Gly?Val

55 60 65

act?gca?cag?ggt?ttg?gat?gtt?gtt?cat?ttg?gga?ctg?act?tct?act?gat 355

Thr?Ala?Gln?Gly?Leu?Asp?Val?Val?His?Leu?Gly?Leu?Thr?Ser?Thr?Asp

70 75 80 85

gag?ctg?tac?ttt?gcg?tcc?gga?acc?ttg?aag?tgt?gct?ggt?gcg?atg?ttt 403

Glu?Leu?Tyr?Phe?Ala?Ser?Gly?Thr?Leu?Lys?Cys?Ala?Gly?Ala?Met?Phe

90 95 100

act?gcg?tcg?cat?aac?ccc?gct?gag?tac?aac?ggc?atc?aag?ttg?tgt?cgt 451

Thr?Ala?Ser?His?Asn?Pro?Ala?Glu?Tyr?Asn?Gly?Ile?Lys?Leu?Cys?Arg

105 110 115

gcg?ggt?gct?cgt?ccg?gtc?ggt?cag?gat?tct?ggt?ttg?gcc?aac?atc?att 499

Ala?Gly?Ala?Arg?Pro?Val?Gly?Gln?Asp?Ser?Gly?Leu?Ala?Asn?Ile?Ile

120 125 130

gat?gat?ctg?gtt?gag?ggt?gtt?cca?gcg?ttt?gat?ggt?gag?tca?ggt?tcg 547

Asp?Asp?Leu?Val?Glu?Gly?Val?Pro?Ala?Phe?Asp?Gly?Glu?Ser?Gly?Ser

135 140 145

gtt?tct?gag?cag?gat?ttg?ctg?agc?gca?tat?gcc?gag?tac?ctc?aat?gag 595

Val?Ser?Glu?Gln?Asp?Leu?Leu?Ser?Ala?Tyr?Ala?Glu?Tyr?Leu?Asn?Glu

150 155 160 165

ctt?gtt?gat?ctg?aag?aac?atc?cgc?ccg?atg?aag?gtt?gct?gtg?gat?gcg 643

Leu?Val?Asp?Leu?Lys?Asn?Ile?Arg?Pro?Met?Lys?Val?Ala?Val?Asp?Ala

170 175 180

gca?aac?ggc?atg?ggt?ggg?ttc?act?gtc?cct?gag?gta?ttc?aag?ggt?ctg 691

Ala?Asn?Gly?Met?Gly?Gly?Phe?Thr?Val?Pro?Glu?Val?Phe?Lys?Gly?Leu

185 190 195

cca?ctt?gat?gtt?gcg?cca?ctg?tat?ttt?gag?ctt?gac?ggc?aat?ttc?ccc 739

Pro?Leu?Asp?Val?Ala?Pro?Leu?Tyr?Phe?Glu?Leu?Asp?Gly?Asn?Phe?Pro

200 205 210

aac?cat?gag?gcc?aat?cct?ctg?gag?cct?gcc?aac?ctg?gtt?gat?ttg?cag 787

Asn?His?Glu?Ala?Asn?Pro?Leu?Glu?Pro?Ala?Asn?Leu?Val?Asp?Leu?Gln

215 220 225

aag?ttt?acc?gta?gag?acc?gga?tct?gat?atc?ggt?ttg?gcg?ttc?gac?ggc 835

Lys?Phe?Thr?Val?Glu?Thr?Gly?Ser?Asp?Ile?Gly?Leu?Ala?Phe?Asp?Gly

230 235 240 245

gat?gcg?gat?cgt?tgc?ttc?gtg?gtc?gat?gag?aag?ggc?cag?cca?gtc?agc 883

Asp?Ala?Asp?Arg?Cys?Phe?Val?Val?Asp?Glu?Lys?Gly?Gln?Pro?Val?Ser

250 255 260

cct?tcg?gcg?atc?tgt?gcg?atc?gta?gcg?gag?cgt?tac?ttg?gag?aag?ctt 931

Pro?Ser?Ala?Ile?Cys?Ala?Ile?Val?Ala?Glu?Arg?Tyr?Leu?Glu?Lys?Leu

265 270 275

ccg?ggt?tcc?acc?atc?atc?cac?aac?ctg?att?acc?tct?aag?gct?gtg?cct 979

Pro?Gly?Ser?Thr?Ile?Ile?His?Asn?Leu?Ile?Thr?Ser?Lys?Ala?Val?Pro

280 285 290

gag?gtg?att?gct?gaa?aac?ggt?ggc?act?gcg?gtg?cgt?act?cgc?gtg?ggt 1027

Glu?Val?Ile?Ala?Glu?Asn?Gly?Gly?Thr?Ala?Val?Arg?Thr?Arg?Val?Gly

295 300 305

cac?tcc?ttc?atc?aag?gcg?aag?atg?gca?gag?acc?ggt?gcg?gcc?ttt?ggt 1075

His?Ser?Phe?Ile?Lys?Ala?Lys?Met?Ala?Glu?Thr?Gly?Ala?Ala?Phe?Gly

310 315 320 325

ggc?gag?cac?tct?gcg?cac?tac?tac?ttc?act?gag?ttc?ttc?aat?gcg?gac 1123

Gly?Glu?His?Ser?Ala?His?Tyr?Tyr?Phe?Thr?Glu?Phe?Phe?Asn?Ala?Asp

330 335 340

tcc?ggc?att?ttg?gct?gcg?atg?cac?gtg?ctg?gct?gcg?ctg?gga?agc?cag 1171

Ser?Gly?Ile?Leu?Ala?Ala?Met?His?Val?Leu?Ala?Ala?Leu?Gly?Ser?Gln

345 350 355

gac?cag?cca?ctc?agt?gag?atg?atg?gct?agg?tat?aac?cgg?tac?gtt?gct 1219

Asp?Gln?Pro?Leu?Ser?Glu?Met?Met?Ala?Arg?Tyr?Asn?Arg?Tyr?Val?Ala

360 365 370

tca?ggc?gag?ttg?aac?tcc?cgt?ttg?gct?aat?gca?gag?gcg?cag?caa?gag 1267

Ser?Gly?Glu?Leu?Asn?Ser?Arg?Leu?Ala?Asn?Ala?Glu?Ala?Gln?Gln?Glu

375 380 385

cgc?acc?cag?gct?gtg?ctc?gat?gcg?ttc?gct?gat?cgc?acc?gag?tcc?gtg 1315

Arg?Thr?Gln?Ala?Val?Leu?Asp?Ala?Phe?Ala?Asp?Arg?Thr?Glu?Ser?Val

390 395 400 405

gac?acc?ctt?gac?ggc?gtg?act?gtg?gaa?ctc?aag?gac?acc?tcc?gcg?tgg 1363

Asp?Thr?Leu?Asp?Gly?Val?Thr?Val?Glu?Leu?Lys?Asp?Thr?Ser?Ala?Trp

410 415 420

ttc?aac?gtg?cgt?gcg?tcc?aac?acc?gag?ccg?ctg?ctt?cgc?ctc?aat?gtt 1411

Phe?Asn?Val?Arg?Ala?Ser?Asn?Thr?Glu?Pro?Leu?Leu?Arg?Leu?Asn?Val

425 430 435

gaa?gct?gca?tcg?aag?gaa?gaa?gtc?gat?gcg?ttg?gta?gcg?gag?att?cta 1459

Glu?Ala?Ala?Ser?Lys?Glu?Glu?Val?Asp?Ala?Leu?Val?Ala?Glu?Ile?Leu

440 445 450

ggg?att?atc?cgc?gca?taatcccatt?ttccggcggg?cat 1497

Gly?Ile?Ile?Arg?Ala

455

<210>38

<211>458

<212>PRT

＜213〉Corynebacterium glutamicum

<400>38

Met?Arg?Thr?Arg?Glu?Ser?Val?Thr?Ala?Val?Ile?Lys?Ala?Tyr?Asp?Val

1 5 10 15

Arg?Gly?Val?Val?Gly?Val?Asp?Ile?Asp?Ala?Asp?Phe?Ile?Ser?Glu?Thr

20 25 30

Gly?Ala?Ala?Phe?Gly?Arg?Leu?Met?Arg?Ser?Glu?Gly?Glu?Thr?Thr?Val

35 40 45

Ala?Ile?Gly?His?Asp?Met?Arg?Asp?Ser?Ser?Pro?Glu?Leu?Ala?Lys?Ala

50 55 60

Phe?Ala?Asp?Gly?Val?Thr?Ala?Gln?Gly?Leu?Asp?Val?Val?His?Leu?Gly

65 70 75 80

Leu?Thr?Ser?Thr?Asp?Glu?Leu?Tyr?Phe?Ala?Ser?Gly?Thr?Leu?Lys?Cys

85 90 95

Ala?Gly?Ala?Met?Phe?Thr?Ala?Ser?His?Asn?Pro?Ala?Glu?Tyr?Asn?Gly

100 105 110

Ile?Lys?Leu?Cys?Arg?Ala?Gly?Ala?Arg?Pro?Val?Gly?Gln?Asp?Ser?Gly

115 120 125

Leu?Ala?Asn?Ile?Ile?Asp?Asp?Leu?Val?Glu?Gly?Val?Pro?Ala?Phe?Asp

130 135 140

Gly?Glu?Ser?Gly?Ser?Val?Ser?Glu?Gln?Asp?Leu?Leu?Ser?Ala?Tyr?Ala

145 150 155 160

Glu?Tyr?Leu?Asn?Glu?Leu?Val?Asp?Leu?Lys?Asn?Ile?Arg?Pro?Met?Lys

165 170 175

Val?Ala?Val?Asp?Ala?Ala?Asn?Gly?Met?Gly?Gly?Phe?Thr?Val?Pro?Glu

180 185 190

Val?Phe?Lys?Gly?Leu?Pro?Leu?Asp?Val?Ala?Pro?Leu?Tyr?Phe?Glu?Leu

195 200 205

Asp?Gly?Asn?Phe?Pro?Asn?His?Glu?Ala?Asn?Pro?Leu?Glu?Pro?Ala?Asn

210 215 220

Leu?Val?Asp?Leu?Gln?Lys?Phe?Thr?Val?Glu?Thr?Gly?Ser?Asp?Ile?Gly

225 230 235 240

Leu?Ala?Phe?Asp?Gly?Asp?Ala?Asp?Arg?Cys?Phe?Val?Val?Asp?Glu?Lys

245 250 255

Gly?Gln?Pro?Val?Ser?Pro?Ser?Ala?Ile?Cys?Ala?Ile?Val?Ala?Glu?Arg

260 265 270

Tyr?Leu?Glu?Lys?Leu?Pro?Gly?Ser?Thr?Ile?Ile?His?Asn?Leu?Ile?Thr

275 280 285

Ser?Lys?Ala?Val?Pro?Glu?Val?Ile?Ala?Glu?Asn?Gly?Gly?Thr?Ala?Val

290 295 300

Arg?Thr?Arg?Val?Gly?His?Ser?Phe?Ile?Lys?Ala?Lys?Met?Ala?Glu?Thr

305 310 315 320

Gly?Ala?Ala?Phe?Gly?Gly?Glu?His?Ser?Ala?His?Tyr?Tyr?Phe?Thr?Glu

325 330 335

Phe?Phe?Asn?Ala?Asp?Ser?Gly?Ile?Leu?Ala?Ala?Met?His?Val?Leu?Ala

340 345 350

Ala?Leu?Gly?Ser?Gln?Asp?Gln?Pro?Leu?Ser?Glu?Met?Met?Ala?Arg?Tyr

355 360 365

Asn?Arg?Tyr?Val?Ala?Ser?Gly?Glu?Leu?Asn?Ser?Arg?Leu?Ala?Asn?Ala

370 375 380

Glu?Ala?Gln?Gln?Glu?Arg?Thr?Gln?Ala?Val?Leu?Asp?Ala?Phe?Ala?Asp

385 390 395 400

Arg?Thr?Glu?Ser?Val?Asp?Thr?Leu?Asp?Gly?Val?Thr?Val?Glu?Leu?Lys

405 410 415

Asp?Thr?Ser?Ala?Trp?Phe?Asn?Val?Arg?Ala?Ser?Asn?Thr?Glu?Pro?Leu

420 425 430

Leu?Arg?Leu?Asn?Val?Glu?Ala?Ala?Ser?Lys?Glu?Glu?Val?Asp?Ala?Leu

435 440 445

Val?Ala?Glu?Ile?Leu?Gly?Ile?Ile?Arg?Ala

450 455

<210>39

<211>994

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(994)

<223>FRXA01365

<400>39

cctgatcagg?acgaatcata?aggtttgcta?ttcggattgg?atcctttggc?aggggtagga?60

ttgcaagcgt?tattttgttc?cctaacccct?tcgaggattt?atg?cgt?acc?cgt?gaa 115

Met?Arg?Thr?Arg?Glu

1 5

tct?gtc?aca?gct?gta?att?aag?gcg?tat?gac?gtc?cgt?ggt?gtt?gtt?ggt 163

Ser?Val?Thr?Ala?Val?Ile?Lys?Ala?Tyr?Asp?Val?Arg?Gly?Val?Val?Gly

10 15 20

gtc?gat?att?gat?gct?gat?ttc?att?tct?gag?act?ggc?gct?gcc?ttt?ggt 211

Val?Asp?Ile?Asp?Ala?Asp?Phe?Ile?Ser?Glu?Thr?Gly?Ala?Ala?Phe?Gly

25 30 35

cgg?ctc?atg?cgt?agt?gag?ggt?gaa?acc?acc?gtt?gct?att?ggc?cat?gac 259

Arg?Leu?Met?Arg?Ser?Glu?Gly?Glu?Thr?Thr?Val?Ala?Ile?Gly?His?Asp

40 45 50

atg?cgt?gat?tcc?tcc?cct?gaa?ttg?gcc?aag?gcg?ttt?gcc?gat?ggc?gtg 307

Met?Arg?Asp?Ser?Ser?Pro?Glu?Leu?Ala?Lys?Ala?Phe?Ala?Asp?Gly?Val

55 60 65

act?gca?cag?ggt?ttg?gat?gtt?gtt?cat?ttg?gga?ctg?act?tct?act?gat 355

Thr?Ala?Gln?Gly?Leu?Asp?Val?Val?His?Leu?Gly?Leu?Thr?Ser?Thr?Asp

70 75 80 85

gag?ctg?tac?ttt?gcg?tcc?gga?acc?ttg?aag?tgt?gct?ggt?gcg?atg?ttt 403

Glu?Leu?Tyr?Phe?Ala?Ser?Gly?Thr?Leu?Lys?Cys?Ala?Gly?Ala?Met?Phe

90 95 100

act?gcg?tcg?cat?aac?ccc?gct?gag?tac?aac?ggc?atc?aag?ttg?tgt?cgt 451

Thr?Ala?Ser?His?Asn?Pro?Ala?Glu?Tyr?Asn?Gly?Ile?Lys?Leu?Cys?Arg

105 110 115

gcg?ggt?gct?cgt?ccg?gtc?ggt?cag?gat?tct?ggt?ttg?gcc?aac?atc?att 499

Ala?Gly?Ala?Arg?Pro?Val?Gly?Gln?Asp?Ser?Gly?Leu?Ala?Asn?Ile?Ile

120 125 130

gat?gat?ctg?gtt?gag?ggt?gtt?cca?gcg?ttt?gat?ggt?gag?tca?ggt?tcg 547

Asp?Asp?Leu?Val?Glu?Gly?Val?Pro?Ala?Phe?Asp?Gly?Glu?Ser?Gly?Ser

135 140 145

gtt?tct?gag?cag?gat?ttg?ctg?agc?gca?tat?gcc?gag?tac?ctc?aat?gag 595

Val?Ser?Glu?Gln?Asp?Leu?Leu?Ser?Ala?Tyr?Ala?Glu?Tyr?Leu?Asn?Glu

150 155 160 165

ctt?gtt?gat?ctg?aag?aac?atc?cgc?ccg?atg?aag?gtt?gct?gtg?gat?gcg 643

Leu?Val?Asp?Leu?Lys?Asn?Ile?Arg?Pro?Met?Lys?Val?Ala?Val?Asp?Ala

170 175 180

gca?aac?ggc?atg?ggt?ggg?ttc?act?gtc?cct?gag?gta?ttc?aag?ggt?ctg 691

Ala?Asn?Gly?Met?Gly?Gly?Phe?Thr?Val?Pro?Glu?Val?Phe?Lys?Gly?Leu

185 190 195

cca?ctt?gat?gtt?gcg?cca?ctg?tat?ttt?gag?ctt?gac?ggc?aat?ttc?ccc 739

Pro?Leu?Asp?Val?Ala?Pro?Leu?Tyr?Phe?Glu?Leu?Asp?Gly?Asn?Phe?Pro

200 205 210

aac?cat?gag?gcc?aat?cct?ctg?gag?cct?gcc?aac?ctg?gtt?gat?ttg?cag 787

Asn?His?Glu?Ala?Asn?Pro?Leu?Glu?Pro?Ala?Asn?Leu?Val?Asp?Leu?Gln

215 220 225

aag?ttt?acc?gta?gag?acc?gga?tct?gat?atc?ggt?ttg?gcg?ttc?gac?ggc 835

Lys?Phe?Thr?Val?Glu?Thr?Gly?Ser?Asp?Ile?Gly?Leu?Ala?Phe?Asp?Gly

230 235 240 245

gat?gcg?gat?cgt?tgc?ttc?gtg?gtc?gat?gag?aag?ggc?cag?cca?gtc?agc 883

Asp?Ala?Asp?Arg?Cys?Phe?Val?Val?Asp?Glu?Lys?Gly?Gln?Pro?Val?Ser

250 255 260

cct?tcg?gcg?atc?tgt?gcg?atc?gta?gcg?gag?cgt?tac?ttg?gag?aag?ctt 931

Pro?Ser?Ala?Ile?Cys?Ala?Ile?Val?Ala?Glu?Arg?Tyr?Leu?Glu?Lys?Leu

265 270 275

ccg?ggt?tcc?acc?atc?atc?cac?aac?ctg?att?acc?tct?aag?gct?gtg?cct 979

Pro?Gly?Ser?Thr?Ile?Ile?His?Asn?Leu?Ile?Thr?Ser?Lys?Ala?Val?Pro

280 285 290

gag?gtg?att?gct?gaa 994

Glu?Val?Ile?Ala?Glu

295

<210>40

<211>298

<212>PRT

＜213〉Corynebacterium glutamicum

<400>40

Met?Arg?Thr?Arg?Glu?Ser?Val?Thr?Ala?Val?Ile?Lys?Ala?Tyr?Asp?Val

1 5 10 15

Arg?Gly?Val?Val?Gly?Val?Asp?Ile?Asp?Ala?Asp?Phe?Ile?Ser?Glu?Thr

20 25 30

Gly?Ala?Ala?Phe?Gly?Arg?Leu?Met?Arg?Ser?Glu?Gly?Glu?Thr?Thr?Val

35 40 45

Ala?Ile?Gly?His?Asp?Met?Arg?Asp?Ser?Ser?Pro?Glu?Leu?Ala?Lys?Ala

50 55 60

Phe?Ala?Asp?Gly?Val?Thr?Ala?Gln?Gly?Leu?Asp?Val?Val?His?Leu?Gly

65 70 75 80

Leu?Thr?Ser?Thr?Asp?Glu?Leu?Tyr?Phe?Ala?Ser?Gly?Thr?Leu?Lys?Cys

85 90 95

Ala?Gly?Ala?Met?Phe?Thr?Ala?Ser?His?Asn?Pro?Ala?Glu?Tyr?Asn?Gly

100 105 110

Ile?Lys?Leu?Cys?Arg?Ala?Gly?Ala?Arg?Pro?Val?Gly?Gln?Asp?Ser?Gly

115 120 125

Leu?Ala?Asn?Ile?Ile?Asp?Asp?Leu?Val?Glu?Gly?Val?Pro?Ala?Phe?Asp

130 135 140

Gly?Glu?Ser?Gly?Ser?Val?Ser?Glu?Gln?Asp?Leu?Leu?Ser?Ala?Tyr?Ala

145 150 155 160

Glu?Tyr?Leu?Asn?Glu?Leu?Val?Asp?Leu?Lys?Asn?Ile?Arg?Pro?Met?Lys

165 170 175

Val?Ala?Val?Asp?Ala?Ala?Asn?Gly?Met?Gly?Gly?Phe?Thr?Val?Pro?Glu

180 185 190

Val?Phe?Lys?Gly?Leu?Pro?Leu?Asp?Val?Ala?Pro?Leu?Tyr?Phe?Glu?Leu

195 200 205

Asp?Gly?Asn?Phe?Pro?Asn?His?Glu?Ala?Asn?Pro?Leu?Glu?Pro?Ala?Asn

210 215 220

Leu?Val?Asp?Leu?Gln?Lys?Phe?Thr?Val?Glu?Thr?Gly?Ser?Asp?Ile?Gly

225 230 235 240

Leu?Ala?Phe?Asp?Gly?Asp?Ala?Asp?Arg?Cys?Phe?Val?Val?Asp?Glu?Lys

245 250 255

Gly?Gln?Pro?Val?Ser?Pro?Ser?Ala?Ile?Cys?Ala?Ile?Val?Ala?Glu?Arg

260 265 270

Tyr?Leu?Glu?Lys?Leu?Pro?Gly?Ser?Thr?Ile?Ile?His?Asn?Leu?Ile?Thr

275 280 285

Ser?Lys?Ala?Val?Pro?Glu?Val?Ile?Ala?Glu

290 295

<210>41

<211>1743

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1720)

<223>RXA00098

<400>41

taaatttgtc?gtgtttccca?ctttgaacac?tcttcgatgc?gcttggccac?aaaagcaagc?60

taacctgaag?atgttattta?acgacaataa?aggagttttc?atg?gcg?gac?att?tcg 115

Met?Ala?Asp?Ile?Ser

1 5

acc?acc?cag?gtt?tgg?caa?gac?ctg?acc?gat?cat?tac?tca?aac?ttc?cag 163

Thr?Thr?Gln?Val?Trp?Gln?Asp?Leu?Thr?Asp?His?Tyr?Ser?Asn?Phe?Gln

10 15 20

gca?acc?act?ctg?cgt?gaa?ctt?ttc?aag?gaa?gaa?aac?cgc?gcc?gag?aag 211

Ala?Thr?Thr?Leu?Arg?Glu?Leu?Phe?Lys?Glu?Glu?Asn?Arg?Ala?Glu?Lys

25 30 35

tac?acc?ttc?tcc?gcg?gct?ggc?ctc?cac?gtc?gac?ctg?tcg?aag?aat?ctg 259

Tyr?Thr?Phe?Ser?Ala?Ala?Gly?Leu?His?Val?Asp?Leu?Ser?Lys?Asn?Leu

40 45 50

ctt?gac?gac?gcc?acc?ctc?acc?aag?ctc?ctt?gca?ctg?acc?gaa?gaa?tct 307

Leu?Asp?Asp?Ala?Thr?Leu?Thr?Lys?Leu?Leu?Ala?Leu?Thr?Glu?Glu?Ser

55 60 65

ggc?ctt?cgc?gaa?cgc?att?gac?gcg?atg?ttt?gcc?ggt?gaa?cac?ctc?aac 355

Gly?Leu?Arg?Glu?Arg?Ile?Asp?Ala?Met?Phe?Ala?Gly?Glu?His?Leu?Asn

70 75 80 85

aac?acc?gaa?gac?cgc?gct?gtc?ctc?cac?acc?gcg?ctg?cgc?ctt?cct?gcc 403

Asn?Thr?Glu?Asp?Arg?Ala?Val?Leu?His?Thr?Ala?Leu?Arg?Leu?Pro?Ala

90 95 100

gaa?gct?gat?ctg?tca?gta?gat?ggc?caa?gat?gtt?gct?gct?gat?gtc?cac 451

Glu?Ala?Asp?Leu?Ser?Val?Asp?Gly?Gln?Asp?Val?Mla?Ala?Asp?Val?His

105 110 115

gaa?gtt?ttg?gga?cgc?atg?cgt?gac?ttc?gct?act?gcg?ctg?cgc?tca?ggc 499

Glu?Val?Leu?Gly?Arg?Met?Arg?Asp?Phe?Ala?Thr?Ala?Leu?Arg?Ser?Gly

120 125 130

aac?tgg?ttg?gga?cac?acc?ggc?cac?acg?atc?aag?aag?atc?gtc?aac?att 547

Asn?Trp?Leu?Gly?His?Thr?Gly?His?Thr?Ile?Lys?Lys?Ile?Val?Asn?Ile

135 140 145

ggt?atc?ggt?ggc?tct?gac?ctc?gga?cca?gcc?atg?gct?acg?aag?gct?ctg 595

Gly?Ile?Gly?Gly?Ser?Asp?Leu?Gly?Pro?Ala?Met?Ala?Thr?Lys?Ala?Leu

150 155 160 165

cgt?gca?tac?gcg?acc?gct?ggt?atc?tca?gca?gaa?ttc?gtc?tcc?aac?gtc 643

Arg?Ala?Tyr?Ala?Thr?Ala?Gly?Ile?Ser?Ala?Glu?Phe?Val?Ser?Asn?Val

170 175 180

gac?cca?gca?gac?ctc?gtt?tct?gtg?ttg?gaa?gac?ctc?gat?gca?gaa?tcc 691

Asp?Pro?Ala?Asp?Leu?Val?Ser?Val?Leu?Glu?Asp?Leu?Asp?Ala?Glu?Ser

185 190 195

aca?ttg?ttc?gtg?atc?gct?tcg?aaa?act?ttc?acc?acc?cag?gag?acg?ctg 739

Thr?Leu?Phe?Val?Ile?Ala?Ser?Lys?Thr?Phe?Thr?Thr?Gln?Glu?Thr?Leu

200 205 210

tcc?aac?gct?cgt?gca?gct?cgt?gct?tgg?ctg?gta?gag?aag?ctc?ggt?gaa 787

Ser?Asn?Ala?Arg?Ala?Ala?Arg?Ala?Trp?Leu?Val?Glu?Lys?Leu?Gly?Glu

215 220 225

gag?gct?gtc?gcg?aag?cac?ttc?gtc?gca?gtg?tcc?acc?aat?gct?gaa?aag 835

Glu?Ala?Val?Ala?Lys?His?Phe?Val?Ala?Val?Ser?Thr?Asn?Ala?Glu?Lys

230 235 240 245

gtc?gca?gag?ttc?ggt?atc?gac?acg?gac?aac?atg?ttc?ggc?ttc?tgg?gac 883

Val?Ala?Glu?Phe?Gly?Ile?Asp?Thr?Asp?Asn?Met?Phe?Gly?Phe?Trp?Asp

250 255 260

tgg?gtc?gga?ggt?cgt?tac?tcc?gtg?gac?tcc?gca?gtt?ggt?ctt?tcc?ctc 931

Trp?Val?Gly?Gly?Arg?Tyr?Ser?Val?Asp?Ser?Ala?Val?Gly?Leu?Ser?Leu

265 270 275

atg?gca?gtg?atc?ggc?cct?cgc?gac?ttc?atg?cgt?ttc?ctc?ggt?gga?ttc 979

Met?Ala?Val?Ile?Gly?Pro?Arg?Asp?Phe?Met?Arg?Phe?Leu?Gly?Gly?Phe

280 285 290

cac?gcg?atg?gat?gaa?cac?ttc?cgc?acc?acc?aag?ttc?gaa?gag?aac?gtt 1027

His?Ala?Met?Asp?Glu?His?Phe?Arg?Thr?Thr?Lys?Phe?Glu?Glu?Asn?Val

295 300 305

cca?atc?ttg?atg?gct?ctg?ctc?ggt?gtc?tgg?tac?tcc?gat?ttc?tat?ggt 1075

Pro?Ile?Leu?Met?Ala?Leu?Leu?Gly?Val?Trp?Tyr?Ser?Asp?Phe?Tyr?Gly

310 315 320 325

gca?gaa?acc?cac?gct?gtc?cta?cct?tat?tcc?gag?gat?ctc?agc?cgt?ttt 1123

Ala?Glu?Thr?His?Ala?Val?Leu?Pro?Tyr?Ser?Glu?Asp?Leu?Ser?Arg?Phe

330 335 340

gct?gct?tac?ctc?cag?cag?ctg?acc?atg?gaa?tca?aat?ggc?aag?tca?gtc 1171

Ala?Ala?Tyr?Leu?Gln?Gln?Leu?Thr?Met?Glu?Ser?Asn?Gly?Lys?Ser?Val

345 350 355

cac?cgc?gac?ggc?tcc?cct?gtt?tcc?act?ggc?act?ggc?gaa?att?tac?tgg 1219

His?Arg?Asp?Gly?Ser?Pro?Val?Ser?Thr?Gly?Thr?Gly?Glu?Ile?Tyr?Trp

360 365 370

ggt?gag?cct?ggc?aca?aat?ggc?cag?cac?gct?ttc?ttc?cag?ctg?atc?cac 1267

Gly?Glu?Pro?Gly?Thr?Asn?Gly?Gln?His?Ala?Phe?Phe?Gln?Leu?Ile?His

375 380 385

cag?ggc?act?cgc?ctt?gtt?cca?gct?gat?ttc?att?ggt?ttc?gct?cgt?cca 1315

Gln?Gly?Thr?Arg?Leu?Val?Pro?Ala?Asp?Phe?Ile?Gly?Phe?Ala?Arg?Pro

390 395 400 405

aag?cag?gat?ctt?cct?gcc?ggt?gag?cgc?acc?atg?cat?gac?ctt?ttg?atg 1363

Lys?Gln?Asp?Leu?Pro?Ala?Gly?Glu?Arg?Thr?Met?His?Asp?Leu?Leu?Met

410 415 420

agc?aac?ttc?ttc?gca?cag?acc?aag?gtt?ttg?gct?ttc?ggt?aag?aac?gct 1411

Ser?Asn?Phe?Phe?Ala?Gln?Thr?Lys?Val?Leu?Ala?Phe?Gly?Lys?Asn?Ala

425 430 435

gaa?gag?atc?gct?gcg?gaa?ggt?gtc?gca?cct?gag?ctg?gtc?aac?cac?aag 1459

Glu?Glu?Ile?Ala?Ala?Glu?Gly?Val?Ala?Pro?Glu?Leu?Val?Asn?His?Lys

440 445 450

gtc?atg?cca?ggt?aat?cgc?cca?acc?acc?acc?att?ttg?gcg?gag?gaa?ctt 1507

Val?Met?Pro?Gly?Asn?Arg?Pro?Thr?Thr?Thr?Ile?Leu?Ala?Glu?Glu?Leu

455 460 465

acc?cct?tct?att?ctc?ggt?gcg?ttg?atc?gct?ttg?tac?gaa?cac?atc?gtg 1555

Thr?Pro?Ser?Ile?Leu?Gly?Ala?Leu?Ile?Ala?Leu?Tyr?Glu?His?Ile?Val

470 475 480 485

atg?gtt?cag?ggc?gtg?att?tgg?gac?atc?aac?tcc?ttc?gac?caa?tgg?ggt 1603

Met?Val?Gln?Gly?Val?Ile?Trp?Asp?Ile?Asn?Ser?Phe?Asp?Gln?Trp?Gly

490 495 500

gtt?gaa?ctg?ggc?aaa?cag?cag?gca?aat?gac?ctc?gct?ccg?gct?gtc?tct 1651

Val?Glu?Leu?Gly?Lys?Gln?Gln?Ala?Asn?Asp?Leu?Ala?Pro?Ala?Val?Ser

505 510 515

ggt?gaa?gag?gat?gtt?gac?tcg?gga?gat?tct?tcc?act?gat?tca?ctg?att 1699

Gly?Glu?Glu?Asp?Val?Asp?Ser?Gly?Asp?Ser?Ser?Thr?Asp?Ser?Leu?Ile

520 525 530

aag?tgg?tac?cgc?gca?aat?agg?tagtcgcttg?cttatagggt?cag 1743

Lys?Trp?Tyr?Arg?Ala?Asn?Arg

535 540

<210>42

<211>540

<212>PRT

＜213〉Corynebacterium glutamicum

<400>42

Met?Ala?Asp?Ile?Ser?Thr?Thr?Gln?Val?Trp?Gln?Asp?Leu?Thr?Asp?His

1 5 10 15

Tyr?Ser?Asn?Phe?Gln?Ala?Thr?Thr?Leu?Arg?Glu?Leu?Phe?Lys?Glu?Glu

20 25 30

Asn?Arg?Ala?Glu?Lys?Tyr?Thr?Phe?Ser?Ala?Ala?Gly?Leu?His?Val?Asp

35 40 45

Leu?Ser?Lys?Asn?Leu?Leu?Asp?Asp?Ala?Thr?Leu?Thr?Lys?Leu?Leu?Ala

50 55 60

Leu?Thr?Glu?Glu?Ser?Gly?Leu?Arg?Glu?Arg?Ile?Asp?Ala?Met?Phe?Ala

65 70 75 80

Gly?Glu?His?Leu?Asn?Asn?Thr?Glu?Asp?Arg?Ala?Val?Leu?His?Thr?Ala

85 90 95

Leu?Arg?Leu?Pro?Ala?Glu?Ala?Asp?Leu?Ser?Val?Asp?Gly?Gln?Asp?Val

100 105 110

Ala?Ala?Asp?Val?His?Glu?Val?Leu?Gly?Arg?Met?Arg?Asp?Phe?Ala?Thr

115 120 125

Ala?Leu?Arg?Ser?Gly?Asn?Trp?Leu?Gly?His?Thr?Gly?His?Thr?Ile?Lys

130 135 140

Lys?Ile?Val?Asn?Ile?Gly?Ile?Gly?Gly?Ser?Asp?Leu?Gly?Pro?Ala?Met

145 150 155 160

Ala?Thr?Lys?Ala?Leu?Arg?Ala?Tyr?Ala?Thr?Ala?Gly?Ile?Ser?Ala?Glu

165 170 175

Phe?Val?Ser?Asn?Val?Asp?Pro?Ala?Asp?Leu?Val?Ser?Val?Leu?Glu?Asp

180 185 190

Leu?Asp?Ala?Glu?Ser?Thr?Leu?Phe?Val?Ile?Ala?Ser?Lys?Thr?Phe?Thr

195 200 205

Thr?Gln?Glu?Thr?Leu?Ser?Asn?Ala?Arg?Ala?Ala?Arg?Ala?Trp?Leu?Val

210 215 220

Glu?Lys?Leu?Gly?Glu?Glu?Ala?Val?Ala?Lys?His?Phe?Val?Ala?Val?Ser

225 230 235 240

Thr?Asn?Ala?Glu?Lys?Val?Ala?Glu?Phe?Gly?Ile?Asp?Thr?Asp?Asn?Met

245 250 255

Phe?Gly?Phe?Trp?Asp?Trp?Val?Gly?Gly?Arg?Tyr?Ser?Val?Asp?Ser?Ala

260 265 270

Val?Gly?Leu?Ser?Leu?Met?Ala?Val?Ile?Gly?Pro?Arg?Asp?Phe?Met?Arg

275 280 285

Phe?Leu?Gly?Gly?Phe?His?Ala?Met?Asp?Glu?His?Phe?Arg?Thr?Thr?Lys

290 295 300

Phe?Glu?Glu?Asn?Val?Pro?Ile?Leu?Met?Ala?Leu?Leu?Gly?Val?Trp?Tyr

305 310 315 320

Ser?Asp?Phe?Tyr?Gly?Ala?Glu?Thr?His?Ala?Val?Leu?Pro?Tyr?Ser?Glu

325 330 335

Asp?Leu?Ser?Arg?Phe?Ala?Ala?Tyr?Leu?Gln?Gln?Leu?Thr?Met?Glu?Ser

340 345 350

Asn?Gly?Lys?Ser?Val?His?Arg?Asp?Gly?Ser?Pro?Val?Ser?Thr?Gly?Thr

355 360 365

Gly?Glu?Ile?Tyr?Trp?Gly?Glu?Pro?Gly?Thr?Asn?Gly?Gln?His?Ala?Phe

370 375 380

Phe?Gln?Leu?Ile?His?Gln?Gly?Thr?Arg?Leu?Val?Pro?Ala?Asp?Phe?Ile

385 390 395 400

Gly?Phe?Ala?Arg?Pro?Lys?Gln?Asp?Leu?Pro?Ala?Gly?Glu?Arg?Thr?Met

405 410 415

His?Asp?Leu?Leu?Met?Ser?Asn?Phe?Phe?Ala?Gln?Thr?Lys?Val?Leu?Ala

420 425 430

Phe?Gly?Lys?Asn?Ala?Glu?Glu?Ile?Ala?Ala?Glu?Gly?Val?Ala?Pro?Glu

435 440 445

Leu?Val?Asn?His?Lys?Val?Met?Pro?Gly?Asn?Arg?Pro?Thr?Thr?Thr?Ile

450 455 460

Leu?Ala?Glu?Glu?Leu?Thr?Pro?Ser?Ile?Leu?Gly?Ala?Leu?Ile?Ala?Leu

465 470 475 480

Tyr?Glu?His?Ile?Val?Met?Val?Gln?Gly?Val?Ile?Trp?Asp?Ile?Asn?Ser

485 490 495

Phe?Asp?Gln?Trp?Gly?Val?Glu?Leu?Gly?Lys?Gln?Gln?Ala?Asn?Asp?Leu

500 505 510

Ala?Pro?Ala?Val?Ser?Gly?Glu?Glu?Asp?Val?Asp?Ser?Gly?Asp?Ser?Ser

515 520 525

Thr?Asp?Ser?Leu?Ile?Lys?Trp?Tyr?Arg?Ala?Asn?Arg

530 535 540

<210>43

<211>630

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(630)

<223>RXA01989

<400>43

gtt?aaa?tca?att?cac?aaa?aca?att?cat?gaa?ggt?act?ggt?gca?ggt?agt 48

Val?Lys?Ser?Ile?His?Lys?Thr?Ile?His?Glu?Gly?Thr?Gly?Ala?Gly?Ser

1 5 10 15

gac?ttc?tta?ggc?tgg?gtt?gat?tta?cca?gtt?gat?tac?gac?aaa?gaa?gaa 96

Asp?Phe?Leu?Gly?Trp?Val?Asp?Leu?Pro?Val?Asp?Tyr?Asp?Lys?Glu?Glu

20 25 30

ttt?tca?aga?att?gtt?gaa?gca?tca?aaa?cgc?att?aaa?gaa?aat?tct?gat 144

Phe?Ser?Arg?Ile?Val?Glu?Ala?Ser?Lys?Arg?Ile?Lys?Glu?Asn?Ser?Asp

35 40 45

gtt?tta?gta?gtc?atc?ggt?att?ggt?ggt?tct?tac?tta?ggt?gca?cgt?gca 192

Val?Leu?Val?Val?Ile?Gly?Ile?Gly?Gly?Ser?Tyr?Leu?Gly?Ala?Arg?Ala

50 55 60

gca?atc?gaa?atg?tta?acg?tca?tca?ttt?aga?aac?agc?aat?gaa?tac?cct 240

Ala?Ile?Glu?Met?Leu?Thr?Ser?Ser?Phe?Arg?Asn?Ser?Asn?Glu?Tyr?Pro

65 70 75 80

gaa?att?gta?ttt?gtt?ggt?aat?cac?tta?tca?tca?aca?tat?acg?aaa?gag 288

Glu?Ile?Val?Phe?Val?Gly?Asn?His?Leu?Ser?Ser?Thr?Tyr?Thr?Lys?Glu

85 90 95

tta?gtt?gat?tat?tta?gca?gac?aaa?gat?ttc?tct?gta?aac?gtt?att?tct 336

Leu?Val?Asp?Tyr?Leu?Ala?Asp?Lys?Asp?Phe?Ser?Val?Asn?Val?Ile?Ser

100 105 110

aaa?tct?ggt?aca?act?aca?gaa?cca?gca?gtt?gca?ttt?aga?ttg?ttc?aaa 384

Lys?Ser?Gly?Thr?Thr?Thr?Glu?Pro?Ala?Val?Ala?Phe?Arg?Leu?Phe?Lys

115 120 125

caa?tta?gtt?gaa?gaa?aga?tac?ggt?aaa?gaa?gaa?gca?caa?aaa?cgt?ata 432

Gln?Leu?Val?Glu?Glu?Arg?Tyr?Gly?Lys?Glu?Glu?Ala?Gln?Lys?Arg?Ile

130 135 140

ttt?gca?aca?acg?gat?aaa?gaa?aaa?ggt?gct?tta?aaa?cag?ttg?gct?aca 480

Phe?Ala?Thr?Thr?Asp?Lys?Glu?Lys?Gly?Ala?Leu?Lys?Gln?Leu?Ala?Thr

145 150 155 160

aac?gaa?ggt?tat?gaa?acg?ttt?atc?gta?cct?gat?gat?gta?ggt?gga?aga 528

Asn?Glu?Gly?Tyr?Glu?Thr?Phe?Ile?Val?Pro?Asp?Asp?Val?Gly?Gly?Arg

165 170 175

tat?tct?gtt?tta?aca?gca?gta?gga?tta?tta?cca?att?gca?aca?gct?gga 576

Tyr?Ser?Val?Leu?Thr?Ala?Val?Gly?Leu?Leu?Pro?Ile?Ala?Thr?Ala?Gly

180 185 190

att?aac?atc?gaa?gct?atg?atg?att?ggt?gct?gca?aaa?gca?cgt?gaa?gaa 624

Ile?Asn?Ile?Glu?Ala?Met?Met?Ile?Gly?Ala?Ala?Lys?Ala?Arg?Glu?Glu

195 200 205

tta?tct 630

Leu?Ser

210

<210>44

<211>210

<212>PRT

＜213〉Corynebacterium glutamicum

<400>44

Val?Lys?Ser?Ile?His?Lys?Thr?Ile?His?Glu?Gly?Thr?Gly?Ala?Gly?Ser

1 5 10 15

Asp?Phe?Leu?Gly?Trp?Val?Asp?Leu?Pro?Val?Asp?Tyr?Asp?Lys?Glu?Glu

20 25 30

Phe?Ser?Arg?Ile?Val?Glu?Ala?Ser?Lys?Arg?Ile?Lys?Glu?Asn?Ser?Asp

35 40 45

Val?Leu?Val?Val?Ile?Gly?Ile?Gly?Gly?Ser?Tyr?Leu?Gly?Ala?Arg?Ala

50 55 60

Ala?Ile?Glu?Met?Leu?Thr?Ser?Ser?Phe?Arg?Asn?Ser?Asn?Glu?Tyr?Pro

65 70 75 80

Glu?Ile?Val?Phe?Val?Gly?Asn?His?Leu?Ser?Ser?Thr?Tyr?Thr?Lys?Glu

85 90 95

Leu?Val?Asp?Tyr?Leu?Ala?Asp?Lys?Asp?Phe?Ser?Val?Asn?Val?Ile?Ser

100 105 110

Lys?Ser?Gly?Thr?Thr?Thr?Glu?Pro?Ala?Val?Ala?Phe?Arg?Leu?Phe?Lys

115 120 125

Gln?Leu?Val?Glu?Glu?Arg?Tyr?Gly?Lys?Glu?Glu?Ala?Gln?Lys?Arg?Ile

130 135 140

Phe?Ala?Thr?Thr?Asp?Lys?Glu?Lys?Gly?Ala?Leu?Lys?Gln?Leu?Ala?Thr

145 150 155 160

Asn?Glu?Gly?Tyr?Glu?Thr?Phe?Ile?Val?Pro?Asp?Asp?Val?Gly?Gly?Arg

165 170 175

Tyr?Ser?Val?Leu?Thr?Ala?Val?Gly?Leu?Leu?Pro?Ile?Ala?Thr?Ala?Gly

180 185 190

Ile?Asn?Ile?Glu?Ala?Met?Met?Ile?Gly?Ala?Ala?Lys?Ala?Arg?Glu?Glu

195 200 205

Leu?Ser

210

<210>45

<211>1269

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1246)

<223>RXA00340

<400>45

cggtatctcc?gacatccgca?acacccccaa?agatgaggtt?ccacagtgcc?cagaatgtgg?60

ctcttacctc?atcactgaca?tctcttagaa?agaccaccca?gtg?aaa?tta?gtc?atc 115

Val?Lys?Leu?Val?Ile

1 5

gag?gcc?gac?ggc?ggc?tcc?cgc?gga?aac?ccc?ggc?gtc?gcc?ggc?tcc?ggc 163

Glu?Ala?Asp?Gly?Gly?Ser?Arg?Gly?Asn?Pro?Gly?Val?Ala?Gly?Ser?Gly

10 15 20

acc?gtg?gtg?tac?tcc?gac?aac?aaa?gca?gaa?gtt?ctc?aaa?gaa?atc?gcc 211

Thr?Val?Val?Tyr?Ser?Asp?Asn?Lys?Ala?Glu?Val?Leu?Lys?Glu?Ile?Ala

25 30 35

tat?gtt?gtc?gga?aca?aaa?gcc?acc?aac?aac?gtc?gcc?gaa?tac?cgc?gga 259

Tyr?Val?Val?Gly?Thr?Lys?Ala?Thr?Asn?Asn?Val?Ala?Glu?Tyr?Arg?Gly

40 45 50

cta?ctc?gaa?ggc?ctc?aaa?gca?gcc?cgc?gag?ctc?ggc?gct?acc?tcc?gtg 307

Leu?Leu?Glu?Gly?Leu?Lys?Ala?Ala?Arg?Glu?Leu?Gly?Ala?Thr?Ser?Val

55 60 65

gat?gtc?tac?atg?gac?tcc?aaa?ctt?gtc?gtt?gaa?caa?atg?tcc?ggc?cgg 355

Asp?Val?Tyr?Met?Asp?Ser?Lys?Leu?Val?Val?Glu?Gln?Met?Ser?Gly?Arg

70 75 80 85

tgg?aaa?atc?aaa?cac?ccc?gac?atg?aaa?gtt?cta?gcg?atc?gaa?gcc?aag 403

Trp?Lys?Ile?Lys?His?Pro?Asp?Met?Lys?Val?Leu?Ala?Ile?Glu?Ala?Lys

90 95 100

gag?att?gct?tcc?gaa?atc?ggg?tcc?gtt?tct?tat?acg?tgg?att?ccg?cgt 451

Glu?Ile?Ala?Ser?Glu?Ile?Gly?Ser?Val?Ser?Tyr?Thr?Trp?Ile?Pro?Arg

105 110 115

gag?aaa?aac?aaa?cga?gct?gac?gca?ttg?tcc?aac?gtg?gcg?atg?gat?gct 499

Glu?Lys?Asn?Lys?Arg?Ala?Asp?Ala?Leu?Ser?Asn?Val?Ala?Met?Asp?Ala

120 125 130

gca?gcg?gca?ggt?aag?ccg?gta?ggt?gtt?gta?ggg?gat?tct?gct?tct?gta 547

Ala?Ala?Ala?Gly?Lys?Pro?Val?Gly?Val?Val?Gly?Asp?Ser?Ala?Ser?Val

135 140 145

tct?tct?gct?tct?tcg?gtt?gcg?ggc?tca?gag?aaa?gaa?gac?ctc?aac?tgc 595

Ser?Ser?Ala?Ser?Ser?Val?Ala?Gly?Ser?Glu?Lys?Glu?Asp?Leu?Asn?Cys

150 155 160 165

acc?gaa?acc?aaa?ccc?acc?aac?tgg?aac?ggc?gca?acc?aca?gat?ccc?act 643

Thr?Glu?Thr?Lys?Pro?Thr?Asn?Trp?Asn?Gly?Ala?Thr?Thr?Asp?Pro?Thr

170 175 180

cgt?ttc?ttg?ttg?ctt?cgc?cac?ggc?caa?act?gct?atg?tca?gtg?gca?cgc 691

Arg?Phe?Leu?Leu?Leu?Arg?His?Gly?Gln?Thr?Ala?Met?Ser?Val?Ala?Arg

185 190 195

ctt?tac?tcc?ggt?agg?tcc?aac?cca?gag?ctg?tct?gaa?ctt?ggt?gaa?aaa 739

Leu?Tyr?Ser?Gly?Arg?Ser?Asn?Pro?Glu?Leu?Ser?Glu?Leu?Gly?Glu?Lys

200 205 210

caa?gca?gca?gcg?gca?gca?cga?cga?ctc?gct?caa?acc?ggt?ggc?atc?gac 787

Gln?Ala?Ala?Ala?Ala?Ala?Arg?Arg?Leu?Ala?Gln?Thr?Gly?Gly?Ile?Asp

215 220 225

gct?att?gtg?agt?tct?ccg?ctc?acc?cgc?acg?atg?caa?acc?gca?gaa?gca 835

Ala?Ile?Val?Ser?Ser?Pro?Leu?Thr?Arg?Thr?Met?Gln?Thr?Ala?Glu?Ala

230 235 240 245

gca?gcg?gcc?gca?ctg?gga?atg?aaa?gta?cgt?gtt?atc?gat?gat?ctc?atc 883

Ala?Ala?Ala?Ala?Leu?Gly?Met?Lys?Val?Arg?Val?Ile?Asp?Asp?Leu?Ile

250 255 260

gaa?act?gac?ttt?gga?ctg?tgg?gat?gga?aaa?tca?ttt?tca?gaa?gcc?cac 931

Glu?Thr?Asp?Phe?Gly?Leu?Trp?Asp?Gly?Lys?Ser?Phe?Ser?Glu?Ala?His

265 270 275

gaa?caa?gat?cca?gaa?ctg?cac?acc?aag?tgg?ctc?act?gac?tca?tct?gta 979

Glu?Gln?Asp?Pro?Glu?Leu?His?Thr?Lys?Trp?Leu?Thr?Asp?Ser?Ser?Val

280 285 290

gcc?cca?ccc?ggt?ggt?gag?tcc?ctg?cag?acg?gtt?aat?cga?cgt?gtg?aaa 1027

Ala?Pro?Pro?Gly?Gly?Glu?Ser?Leu?Gln?Thr?Val?Asn?Arg?Arg?Val?Lys

295 300 305

aag?gct?cgt?gaa?agc?ctc?caa?cgc?gaa?tac?ggt?gca?gcg?aat?gtt?ttg 1075

Lys?Ala?Arg?Glu?Ser?Leu?Gln?Arg?Glu?Tyr?Gly?Ala?Ala?Asn?Val?Leu

310 315 320 325

gtg?gtc?agc?cac?gtc?acc?cca?atc?aaa?gcc?atc?atg?agg?caa?gca?ttg 1123

Val?Val?Ser?His?Val?Thr?Pro?Ile?Lys?Ala?Ile?Met?Arg?Gln?Ala?Leu

330 335 340

gac?gca?ggc?cca?tcc?ttc?ttt?cag?aag?gca?cac?ctt?gac?ttg?gcg?tcg 1171

Asp?Ala?Gly?Pro?Ser?Phe?Phe?Gln?Lys?Ala?His?Leu?Asp?Leu?Ala?Ser

345 350 355

ctg?tcg?atc?gca?gag?ttt?tac?gaa?gac?ggc?cca?acc?tgc?gta?aga?ctg 1219

Leu?Ser?Ile?Ala?Glu?Phe?Tyr?Glu?Asp?Gly?Pro?Thr?Cys?Val?Arg?Leu

360 365 370

ttc?aac?gac?acc?tca?cac?ctg?gaa?gcg?tgacgacagt?ctgacggaag 1266

Phe?Asn?Asp?Thr?Ser?His?Leu?Glu?Ala

375 380

ctc 1269

<210>46

<211>382

<212>PRT

＜213〉Corynebacterium glutamicum

<400>46

Val?Lys?Leu?Val?Ile?Glu?Ala?Asp?Gly?Gly?Ser?Arg?Gly?Asn?Pro?Gly

1 5 10 15

Val?Ala?Gly?Ser?Gly?Thr?Val?Val?Tyr?Ser?Asp?Asn?Lys?Ala?Glu?Val

20 25 30

Leu?Lys?Glu?Ile?Ala?Tyr?Val?Val?Gly?Thr?Lys?Ala?Thr?Asn?Asn?Val

35 40 45

Ala?Glu?Tyr?Arg?Gly?Leu?Leu?Glu?Gly?Leu?Lys?Ala?Ala?Arg?Glu?Leu

50 55 60

Gly?Ala?Thr?Ser?Val?Asp?Val?Tyr?Met?Asp?Ser?Lys?Leu?Val?Val?Glu

65 70 75 80

Gln?Met?Ser?Gly?Arg?Trp?Lys?Ile?Lys?His?Pro?Asp?Met?Lys?Val?Leu

85 90 95

Ala?Ile?Glu?Ala?Lys?Glu?Ile?Ala?Ser?Glu?Ile?Gly?Ser?Val?Ser?Tyr

100 105 110

Thr?Trp?Ile?Pro?Arg?Glu?Lys?Asn?Lys?Arg?Ala?Asp?Ala?Leu?Ser?Asn

115 120 125

Val?Ala?Met?Asp?Ala?Ala?Ala?Ala?Gly?Lys?Pro?Val?Gly?Val?Val?Gly

130 135 140

Asp?Ser?Ala?Ser?Val?Ser?Ser?Ala?Ser?Ser?Val?Ala?Gly?Ser?Glu?Lys

145 150 155 160

Glu?Asp?Leu?Asn?Cys?Thr?Glu?Thr?Lys?Pro?Thr?Asn?Trp?Asn?Gly?Ala

165 170 175

Thr?Thr?Asp?Pro?Thr?Arg?Phe?Leu?Leu?Leu?Arg?His?Gly?Gln?Thr?Ala

180 185 190

Met?Ser?Val?Ala?Arg?Leu?Tyr?Ser?Gly?Arg?Ser?Asn?Pro?Glu?Leu?Ser

195 200 205

Glu?Leu?Gly?Glu?Lys?Gln?Ala?Ala?Ala?Ala?Ala?Arg?Arg?Leu?Ala?Gln

210 215 220

Thr?Gly?Gly?Ile?Asp?Ala?Ile?Val?Ser?Ser?Pro?Leu?Thr?Arg?Thr?Met

225 230 235 240

Gln?Thr?Ala?Glu?Ala?Ala?Ala?Ala?Ala?Leu?Gly?Met?Lys?Val?Arg?Val

245 250 255

Ile?Asp?Asp?Leu?Ile?Glu?Thr?Asp?Phe?Gly?Leu?Trp?Asp?Gly?Lys?Ser

260 265 270

Phe?Ser?Glu?Ala?His?Glu?Gln?Asp?Pro?Glu?Leu?His?Thr?Lys?Trp?Leu

275 280 285

Thr?Asp?Ser?Ser?Val?Ala?Pro?Pro?Gly?Gly?Glu?Ser?Leu?Gln?Thr?Val

290 295 300

Asn?Arg?Arg?Val?Lys?Lys?Ala?Arg?Glu?Ser?Leu?Gln?Arg?Glu?Tyr?Gly

305 310 315 320

Ala?Ala?Asn?Val?Leu?Val?Val?Ser?His?Val?Thr?Pro?Ile?Lys?Ala?Ile

325 330 335

Met?Arg?Gln?Ala?Leu?Asp?Ala?Gly?Pro?Ser?Phe?Phe?Gln?Lys?Ala?His

340 345 350

Leu?Asp?Leu?Ala?Ser?Leu?Ser?Ile?Ala?Glu?Phe?Tyr?Glu?Asp?Gly?Pro

355 360 365

Thr?Cys?Val?Arg?Leu?Phe?Asn?Asp?Thr?Ser?His?Leu?Glu?Ala

370 375 380

<210>47

<211>840

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(817)

<223>RXA02492

<400>47

gctgtacaac?gacgctattg?ccaacgaaaa?tgtcgacggt?gaaacgcatc?acggctaagt?60

aaacgcgcgt?cgtggaacat?aaagtggcaa?actagtacct?atg?act?aac?gga?aaa 115

Met?Thr?Asn?Gly?Lys

1 5

ttg?att?ctt?ctt?cgt?cac?ggt?cag?agc?gaa?tgg?aac?gca?tcc?aac?cag 163

Leu?Ile?Leu?Leu?Arg?His?Gly?Gln?Ser?Glu?Trp?Asn?Ala?Ser?Asn?Gln

10 15 20

ttc?act?gga?tgg?gtc?gac?gtc?aat?ctg?acc?gaa?cag?ggt?gag?gct?gag 211

Phe?Thr?Gly?Trp?Val?Asp?Val?Asn?Leu?Thr?Glu?Gln?Gly?Glu?Ala?Glu

25 30 35

gcc?aaa?ggc?gtc?ctc?cca?ggc?gtt?gta?tac?acc?tcc?ttg?ctg?cgt?cgc 259

Ala?Lys?Gly?Val?Leu?Pro?Gly?Val?Val?Tyr?Thr?Ser?Leu?Leu?Arg?Arg

40 45 50

gcg?atc?cgc?act?gca?aac?atc?gca?ctg?aac?gct?gca?gac?cgc?cac?tgg 307

Ala?Ile?Arg?Thr?Ala?Asn?Ile?Ala?Leu?Asn?Ala?Ala?Asp?Arg?His?Trp

55 60 65

atc?cca?gtg?atc?cgc?gac?tgg?cgc?ctc?aac?gag?cgt?cac?tac?ggc?gca 355

Ile?Pro?Val?Ile?Arg?Asp?Trp?Arg?Leu?Asn?Glu?Arg?His?Tyr?Gly?Ala

70 75 80 85

ctg?cag?ggc?ctt?gac?aag?gct?gca?acc?aag?gaa?aaa?tac?ggc?gac?gac 403

Leu?Gln?Gly?Leu?Asp?Lys?Ala?Ala?Thr?Lys?Glu?Lys?Tyr?Gly?Asp?Asp

90 95 100

cag?ttc?atg?gaa?tgg?cgc?cgc?tcc?tac?gac?acc?cca?cca?cca?gag?ctc 451

Gln?Phe?Met?Glu?Trp?Arg?Arg?Ser?Tyr?Asp?Thr?Pro?Pro?Pro?Glu?Leu

105 110 115

gcg?gat?gac?gca?gag?tac?tcc?cag?gca?aat?gac?cct?cgt?tac?gcg?gac 499

Ala?Asp?Asp?Ala?Glu?Tyr?Ser?Gln?Ala?Asn?Asp?Pro?Arg?Tyr?Ala?Asp

120 125 130

ctc?gac?gta?gtt?cca?cgc?acc?gaa?tgc?ctc?aag?gac?gtt?gtg?gtt?cgt 547

Leu?Asp?Val?Val?Pro?Arg?Thr?Glu?Cys?Leu?Lys?Asp?Val?Val?Val?Arg

135 140 145

ttt?gtt?cct?tac?ttc?gag?gaa?gaa?atc?ctg?cca?cgc?gca?aag?aag?ggc 595

Phe?Val?Pro?Tyr?Phe?Glu?Glu?Glu?Ile?Leu?Pro?Arg?Ala?Lys?Lys?Gly

150 155 160 165

gaa?acc?gtc?ctc?atc?gca?gca?cac?ggc?aac?tcc?ctg?cgt?gcg?ctg?gtt 643

Glu?Thr?Val?Leu?Ile?Ala?Ala?His?Gly?Asn?Ser?Leu?Arg?Ala?Leu?Val

170 175 180

aag?cac?ctt?gac?ggc?atc?tcc?gat?gct?gat?atc?gca?gag?ctc?aac?atc 691

Lys?His?Leu?Asp?Gly?Ile?Ser?Asp?Ala?Asp?Ile?Ala?Glu?Leu?Asn?Ile

185 190 195

cca?acc?ggc?atc?cca?ctg?gtc?tac?gaa?atc?gcc?gaa?gac?ggt?tcc?gta 739

Pro?Thr?Gly?Ile?Pro?Leu?Val?Tyr?Glu?Ile?Ala?Glu?Asp?Gly?Ser?Val

200 205 210

gta?aac?cca?ggc?ggc?acc?tac?ctc?gat?cct?gag?gca?gca?gca?gcc?ggc 787

Val?Asn?Pro?Gly?Gly?Thr?Tyr?Leu?Asp?Pro?Glu?Ala?Ala?Ala?Ala?Gly

215 220 225

gca?gca?gca?gta?gca?aac?cag?ggt?aat?aag?tagctatttg?taggtgagca 837

Ala?Ala?Ala?Val?Ala?Asn?Gln?Gly?Asn?Lys

230 235

ctc 840

<210>48

<211>239

<212>PRT

＜213〉Corynebacterium glutamicum

<400>48

Met?Thr?Asn?Gly?Lys?Leu?Ile?Leu?Leu?Arg?His?Gly?Gln?Ser?Glu?Trp

1 5 10 15

Asn?Ala?Ser?Asn?Gln?Phe?Thr?Gly?Trp?Val?Asp?Val?Asn?Leu?Thr?Glu

20 25 30

Gln?Gly?Glu?Ala?Glu?Ala?Lys?Gly?Val?Leu?Pro?Gly?Val?Val?Tyr?Thr

35 40 45

Ser?Leu?Leu?Arg?Arg?Ala?Ile?Arg?Thr?Ala?Asn?Ile?Ala?Leu?Asn?Ala

50 55 60

Ala?Asp?Arg?His?Trp?Ile?Pro?Val?Ile?Arg?Asp?Trp?Arg?Leu?Asn?Glu

65 70 75 80

Arg?His?Tyr?Gly?Ala?Leu?Gln?Gly?Leu?Asp?Lys?Ala?Ala?Thr?Lys?Glu

85 90 95

Lys?Tyr?Gly?Asp?Asp?Gln?Phe?Met?Glu?Trp?Arg?Arg?Ser?Tyr?Asp?Thr

100 105 110

Pro?Pro?Pro?Glu?Leu?Ala?Asp?Asp?Ala?Glu?Tyr?Ser?Gln?Ala?Asn?Asp

115 120 125

Pro?Arg?Tyr?Ala?Asp?Leu?Asp?Val?Val?Pro?Arg?Thr?Glu?Cys?Leu?Lys

130 135 140

Asp?Val?Val?Val?Arg?Phe?Val?Pro?Tyr?Phe?Glu?Glu?Glu?Ile?Leu?Pro

145 150 155 160

Arg?Ala?Lys?Lys?Gly?Glu?Thr?Val?Leu?Ile?Ala?Ala?His?Gly?Asn?Ser

165 170 175

Leu?Arg?Ala?Leu?Val?Lys?His?Leu?Asp?Gly?Ile?Ser?Asp?Ala?Asp?Ile

180 185 190

Ala?Glu?Leu?Asn?Ile?Pro?Thr?Gly?Ile?Pro?Leu?Val?Tyr?Glu?Ile?Ala

195 200 205

Glu?Asp?Gly?Ser?Val?Val?Asn?Pro?Gly?Gly?Thr?Tyr?Leu?Asp?Pro?Glu

210 215 220

Ala?Ala?Ala?Ala?Gly?Ala?Ala?Ala?Val?Ala?Asn?Gln?Gly?Asn?Lys

225 230 235

<210>49

<211>729

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(706)

<223>RXA00381

<400>49

aaacctggtt?tgtgtcttcc?gctctcacggacgatgattt?ctccaagatc?gagcaggcac 60

tcaagcccgc?cgcacgtgca?gcagcagaag?cgaaggcatc?atg?acg?caa?acc?att 115

Met?Thr?Gln?Thr?Ile

1 5

gtc?cat?cta?gtt?cgc?cac?ggc?gaa?gtc?cac?aac?cca?gag?aaa?atc?ctg 163

Val?His?Leu?Val?Arg?His?Gly?Glu?Val?His?Asn?Pro?Glu?Lys?Ile?Leu

10 15 20

tac?gga?cgc?atg?ccc?gga?tac?agg?ttg?tct?tcc?cgt?gga?cgc?agc?caa 211

Tyr?Gly?Arg?Met?Pro?Gly?Tyr?Arg?Leu?Ser?Ser?Arg?Gly?Arg?Ser?Gln

25 30 35

gcc?gcc?cgc?act?gca?gct?tct?ttt?gaa?ggc?cac?gat?gtc?acc?tac?att 259

Ala?Ala?Arg?Thr?Ala?Ala?Ser?Phe?Glu?Gly?His?Asp?Val?Thr?Tyr?Ile

40 45 50

gcg?gcc?tcc?cca?ttg?cag?cgt?gtg?cag?gaa?acc?tcc?gaa?ccg?ttc?atc 307

Ala?Ala?Ser?Pro?Leu?Gln?Arg?Val?Gln?Glu?Thr?Ser?Glu?Pro?Phe?Ile

55 60 65

aag?gtc?aca?ggc?cta?gaa?ctg?atc?acc?gac?gag?gat?ctt?ctg?gaa?gca 355

Lys?Val?Thr?Gly?Leu?Glu?Leu?Ile?Thr?Asp?Glu?Asp?Leu?Leu?Glu?Ala

70 75 80 85

ggc?aac?cgt?ttc?gaa?ggc?ctg?cgc?acc?aaa?ggt?tgg?cgt?tcc?cag?ttg 403

Gly?Asn?Arg?Phe?Glu?Gly?Leu?Arg?Thr?Lys?Gly?Trp?Arg?Ser?Gln?Leu

90 95 100

tgg?aac?ccc?gtg?cgt?tgg?cct?ttg?atg?tac?aac?ccc?acg?ctt?ccc?agc 451

Trp?Asn?Pro?Val?Arg?Trp?Pro?Leu?Met?Tyr?Asn?Pro?Thr?Leu?Pro?Ser

105 110 115

tgg?ggc?gaa?cac?tac?acc?gac?att?ttg?gaa?aga?atg?atg?gcg?gct?gtg 499

Trp?Gly?Glu?His?Tyr?Thr?Asp?Ile?Leu?Glu?Arg?Met?Met?Ala?Ala?Val

120 125 130

gaa?cga?gct?cgg?gtg?gca?gcg?gaa?gga?cac?gaa?gca?atc?ctg?gtg?acc 547

Glu?Arg?Ala?Arg?Val?Ala?Ala?Glu?Gly?His?Glu?Ala?Ile?Leu?Val?Thr

135 140 145

cac?cag?ttg?ccg?atc?gtg?tgc?gtg?caa?cgc?cac?gcc?cgc?gga?caa?agc 595

His?Gln?Leu?Pro?Ile?Val?Cys?Val?Gln?Arg?His?Ala?Arg?Gly?Gln?Ser

150 155 160 165

ctg?tcc?cat?aac?cca?gcg?acc?agg?caa?tgc?gac?ctc?gcc?tca?gtg?aca 643

Leu?Ser?His?Asn?Pro?Ala?Thr?Arg?Gln?Cys?Asp?Leu?Ala?Ser?Val?Thr

170 175 180

tcc?ttg?gtg?ttc?caa?gac?gat?caa?att?gtc?ggc?gtg?cat?tac?aac?gaa 691

Ser?Leu?Val?Phe?Gln?Asp?Asp?Gln?Ile?Val?Gly?Val?His?Tyr?Asn?Glu

185 190 195

cca?gct?cag?gag?att?tgatcactcg?tgcgtttgac?caa 729

Pro?Ala?Gln?Glu?Ile

200

<210>50

<211>202

<212>PRT

＜213〉Corynebacterium glutamicum

<400>50

Met?Thr?Gln?Thr?Ile?Val?His?Leu?Val?Arg?His?Gly?Glu?Val?His?Asn

1 5 10 15

Pro?Glu?Lys?Ile?Leu?Tyr?Gly?Arg?Met?Pro?Gly?Tyr?Arg?Leu?Ser?Ser

20 25 30

Arg?Gly?Arg?Ser?Gln?Ala?Ala?Arg?Thr?Ala?Ala?Ser?Phe?Glu?Gly?His

35 40 45

Asp?Val?Thr?Tyr?Ile?Ala?Ala?Ser?Pro?Leu?Gln?Arg?Val?Gln?Glu?Thr

50 55 60

Ser?Glu?Pro?Phe?Ile?Lys?Val?Thr?Gly?Leu?Glu?Leu?Ile?Thr?Asp?Glu

65 70 75 80

Asp?Leu?Leu?Glu?Ala?Gly?Asn?Arg?Phe?Glu?Gly?Leu?Arg?Thr?Lys?Gly

85 90 95

Trp?Arg?Ser?Gln?Leu?Trp?Asn?Pro?Val?Arg?Trp?Pro?Leu?Met?Tyr?Asn

100 105 110

Pro?Thr?Leu?Pro?Ser?Trp?Gly?Glu?His?Tyr?Thr?Asp?Ile?Leu?Glu?Arg

115 120 125

Met?Met?Ala?Ala?Val?Glu?Arg?Ala?Arg?Val?Ala?Ala?Glu?Gly?His?Glu

130 135 140

Ala?Ile?Leu?Val?Thr?His?Gln?Leu?Pro?Ile?Val?Cys?Val?Gln?Arg?His

145 150 155 160

Ala?Arg?Gly?Gln?Ser?Leu?Ser?His?Asn?Pro?Ala?Thr?Arg?Gln?Cys?Asp

165 170 175

Leu?Ala?Ser?Val?Thr?Ser?Leu?Val?Phe?Gln?Asp?Asp?Gln?Ile?Val?Gly

180 185 190

Val?His?Tyr?Asn?Glu?Pro?Ala?Gln?Glu?Ile

195 200

<210>51

<211>822

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(799)

<223>RXA02122

<400>51

ggccttcagc?tcaccgacag?tttgtacatt?tggtggaaga?ctcacacccc?acaccctaga?60

ccttttttta?agtgggcggt?caggaatttt?tcgcacaggt?atg?ctg?cat?gtc?atg 115

Met?Leu?His?Val?Met

1 5

aag?ccg?ggt?tca?cac?gca?gct?gcc?gaa?aag?act?caa?tcc?act?gtg?gtt 163

Lys?Pro?Gly?Ser?His?Ala?Ala?Ala?Glu?Lys?Thr?Gln?Ser?Thr?Val?Val

10 15 20

tta?ctc?att?cgg?cat?ggg?caa?acc?cca?aca?act?ggt?cag?gtt?ctg?cct 211

Leu?Leu?Ile?Arg?His?Gly?Gln?Thr?Pro?Thr?Thr?Gly?Gln?Val?Leu?Pro

25 30 35

ggt?cag?acg?ccg?ggt?tta?cac?ctg?tct?gat?aag?ggt?gaa?gag?cag?gcg 259

Gly?Gln?Thr?Pro?Gly?Leu?His?Leu?Ser?Asp?Lys?Gly?Glu?Glu?Gln?Ala

40 45 50

cgg?gag?gtg?gca?cag?cgt?ctg?gcg?gag?gtg?ccg?att?acc?gct?gtg?tat 307

Arg?Glu?Val?Ala?Gln?Arg?Leu?Ala?Glu?Val?Pro?Ile?Thr?Ala?Val?Tyr

55 60 65

tca?tcg?ccg?atg?gag?cgt?gcg?cag?gaa?aca?gca?gca?ccg?acg?gtc?agc 355

Ser?Ser?Pro?Met?Glu?Arg?Ala?Gln?Glu?Thr?Ala?Ala?Pro?Thr?Val?Ser

70 75 80 85

gct?cat?ggc?ctc?gag?ttg?acg?gtg?gaa?cct?ggg?ctt?att?gaa?tgc?gat 403

Ala?His?Gly?Leu?Glu?Leu?Thr?Val?Glu?Pro?Gly?Leu?Ile?Glu?Cys?Asp

90 95 100

ttc?ggc?gag?tgg?acg?ggc?cgg?aaa?cta?act?gag?ctc?aat?gcc?cta?gag 451

Phe?Gly?Glu?Trp?Thr?Gly?Arg?Lys?Leu?Thr?Glu?Leu?Asn?Ala?Leu?Glu

105 110 115

gag?tgg?aaa?gcg?gtg?cag?aag?aca?ccg?tct?acc?ttc?agg?ttt?cca?ggt 499

Glu?Trp?Lys?Ala?Val?Gln?Lys?Thr?Pro?Ser?Thr?Phe?Arg?Phe?Pro?Gly

120 125 130

ggt?gag?agt?ttc?gtg?gaa?atg?cag?gat?cgg?atg?gtg?gag?gct?atc?ggc 547

Gly?Glu?Ser?Phe?Val?Glu?Met?Gln?Asp?Arg?Met?Val?Glu?Ala?Ile?Gly

135 140 145

aac?att?gcg?cag?cag?cat?ccg?gga?gaa?atc?gtt?gct?gcg?ttt?agt?cat 595

Asn?Ile?Ala?Gln?Gln?His?Pro?Gly?Glu?Ile?Val?Ala?Ala?Phe?Ser?His

150 155 160 165

gcc?gac?acg?atc?aag?gct?gcg?gtg?gct?cat?ttt?gta?ggc?act?cca?ctg 643

Ala?Asp?Thr?Ile?Lys?Ala?Ala?Val?Ala?His?Phe?Val?Gly?Thr?Pro?Leu

170 175 180

gat?tct?ttt?cag?cgc?att?ttc?atc?gac?acg?gcg?tca?att?tcc?gca?gtg 691

Asp?Ser?Phe?Gln?Arg?Ile?Phe?Ile?Asp?Thr?Ala?Ser?Ile?Ser?Ala?Val

185 190 195

gaa?ttt?acc?ggg?aaa?tct?tca?ggc?gtc?tcc?tcc?cat?atg?ctg?ctg?aca 739

Glu?Phe?Thr?Gly?Lys?Ser?Ser?Gly?Val?Ser?Ser?His?Met?Leu?Leu?Thr

200 205 210

aat?tcc?aga?aca?gga?tcg?ttg?gga?tac?ctt?cga?gac?aaa?ctt?ccg?aaa 787

Asn?Ser?Arg?Thr?Gly?Ser?Leu?Gly?Tyr?Leu?Arg?Asp?Lys?Leu?Pro?Lys

215 220 225

gct?ccg?caa?cca?tgatcacctc?accatttgag?cgc 822

Ala?Pro?Gln?Pro

230

<210>52

<211>233

<212>PRT

＜213〉Corynebacterium glutamicum

<400>52

Met?Leu?His?Val?Met?Lys?Pro?Gly?Ser?His?Ala?Ala?Ala?Glu?Lys?Thr

1 5 10 15

Gln?Ser?Thr?Val?Val?Leu?Leu?Ile?Arg?His?Gly?Gln?Thr?Pro?Thr?Thr

20 25 30

Gly?Gln?Val?Leu?Pro?Gly?Gln?Thr?Pro?Gly?Leu?His?Leu?Ser?Asp?Lys

35 40 45

Gly?Glu?Glu?Gln?Ala?Arg?Glu?Val?Ala?Gln?Arg?Leu?Ala?Glu?Val?Pro

50 55 60

Ile?Thr?Ala?Val?Tyr?Ser?Ser?Pro?Met?Glu?Arg?Ala?Gln?Glu?Thr?Ala

65 70 75 80

Ala?Pro?Thr?Val?Ser?Ala?His?Gly?Leu?Glu?Leu?Thr?Val?Glu?Pro?Gly

85 90 95

Leu?Ile?Glu?Cys?Asp?Phe?Gly?Glu?Trp?Thr?Gly?Arg?Lys?Leu?Thr?Glu

100 105 110

Leu?Asn?Ala?Leu?Glu?Glu?Trp?Lys?Ala?Val?Gln?Lys?Thr?Pro?Ser?Thr

115 120 125

Phe?Arg?Phe?Pro?Gly?Gly?Glu?Ser?Phe?Val?Glu?Met?Gln?Asp?Arg?Met

130 135 140

Val?Glu?Ala?Ile?Gly?Asn?Ile?Ala?Gln?Gln?His?Pro?Gly?Glu?Ile?Val

145 150 155 160

Ala?Ala?Phe?Ser?His?Ala?Asp?Thr?Ile?Lys?Ala?Ala?Val?Ala?His?Phe

165 170 175

Val?Gly?Thr?Pro?Leu?Asp?Ser?Phe?Gln?Arg?Ile?Phe?Ile?Asp?Thr?Ala

180 185 190

Ser?Ile?Ser?Ala?Val?Glu?Phe?Thr?Gly?Lys?Ser?Ser?Gly?Val?Ser?Ser

195 200 205

His?Met?Leu?Leu?Thr?Asn?Ser?Arg?Thr?Gly?Ser?Leu?Gly?Tyr?Leu?Arg

210 215 220

Asp?Lys?Leu?Pro?Lys?Ala?Pro?Gln?Pro

225 230

<210>53

<211>1161

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1138)

<223>RXA00206

<400>53

ttaaataaga?tggtcagaga?cagttttttg?gcctgtcaac?ccctgtgatt?ctcttatttt?60

tgggtgattg?ttccggcgcg?ggtgttgtga?tgggtttaat?atg?gaa?gac?atg?cga 115

Met?Glu?Asp?Met?Arg

1 5

att?gct?act?ctc?acg?tca?ggc?ggc?gac?tgc?ccc?gga?cta?aac?gcc?gtc 163

Ile?Ala?Thr?Leu?Thr?Ser?Gly?Gly?Asp?Cys?Pro?Gly?Leu?Asn?Ala?Val

10 15 20

atc?cga?gga?atc?gtc?cgc?aca?gcc?agc?aat?gaa?ttt?ggc?tcc?acc?gtc 211

Ile?Arg?Gly?Ile?Val?Arg?Thr?Ala?Ser?Asn?Glu?Phe?Gly?Ser?Thr?Val

25 30 35

gtt?ggt?tat?caa?gac?ggt?tgg?gaa?gga?ctg?tta?ggc?gat?cgt?cgc?gta 259

Val?Gly?Tyr?Gln?Asp?Gly?Trp?Glu?Gly?Leu?Leu?Gly?Asp?Arg?Arg?Val

40 45 50

cag?ctg?tat?gac?gat?gaa?gat?att?gac?cga?atc?ctc?ctt?cga?ggc?ggc 307

Gln?Leu?Tyr?Asp?Asp?Glu?Asp?Ile?Asp?Arg?Ile?Leu?Leu?Arg?Gly?Gly

55 60 65

acc?att?ttg?ggc?act?ggt?cgc?ctc?cat?ccg?gac?aag?ttt?aag?gcc?gga 355

Thr?Ile?Leu?Gly?Thr?Gly?Arg?Leu?His?Pro?Asp?Lys?Phe?Lys?Ala?Gly

70 75 80 85

att?gat?cag?att?aag?gcc?aac?tta?gaa?gac?gcc?ggc?atc?gat?gcc?ctt 403

Ile?Asp?Gln?Ile?Lys?Ala?Asn?Leu?Glu?Asp?Ala?Gly?Ile?Asp?Ala?Leu

90 95 100

atc?cca?atc?ggt?ggc?gaa?gga?acc?ctg?aag?ggt?gcc?aag?tgg?ctg?tct 451

Ile?Pro?Ile?Gly?Gly?Glu?Gly?Thr?Leu?Lys?Gly?Ala?Lys?Trp?Leu?Ser

105 110 115

gat?aac?ggt?atc?cct?gtt?gtc?ggt?gtc?cca?aag?acc?att?gac?aat?gac 499

Asp?Asn?Gly?Ile?Pro?Val?Val?Gly?Val?Pro?Lys?Thr?Ile?Asp?Asn?Asp

120 125 130

gtg?aat?ggc?act?gac?ttc?acc?ttc?ggt?ttc?gat?act?gct?gtg?gca?gtg 547

Val?Asn?Gly?Thr?Asp?Phe?Thr?Phe?Gly?Phe?Asp?Thr?Ala?Val?Ala?Val

135 140 145

gct?acc?gac?gct?gtt?gac?cgc?ctg?cac?acc?acc?gct?gaa?tct?cac?aac 595

Ala?Thr?Asp?Ala?Val?Asp?Arg?Leu?His?Thr?Thr?Ala?Glu?Ser?His?Asn

150 155 160 165

cgt?gtg?atg?atc?gtg?gag?gtc?atg?ggc?cgc?cac?gtg?ggt?tgg?att?gct 643

Arg?Val?Met?Ile?Val?Glu?Val?Met?Gly?Arg?His?Val?Gly?Trp?Ile?Ala

170 175 180

ctg?cac?gca?ggt?atg?gcc?ggc?ggt?gct?cac?tac?acc?gtt?att?cca?gaa 691

Leu?His?Ala?Gly?Met?Ala?Gly?Gly?Ala?His?Tyr?Thr?Val?Ile?Pro?Glu

185 190 195

gta?cct?ttc?gat?att?gca?gag?atc?tgc?aag?gcg?atg?gaa?cgt?cgc?ttc 739

Val?Pro?Phe?Asp?Ile?Ala?Glu?Ile?Cys?Lys?Ala?Met?Glu?Arg?Arg?Phe

200 205 210

cag?atg?ggc?gag?aag?tac?ggc?att?atc?gtc?gtt?gcg?gaa?ggt?gcg?ttg 787

Gln?Met?Gly?Glu?Lys?Tyr?Gly?Ile?Ile?Val?Val?Ala?Glu?Gly?Ala?Leu

215 220 225

cca?cgc?gaa?ggc?acc?atg?gag?ctt?cgt?gaa?ggc?cac?att?gac?cag?ttc 835

Pro?Arg?Glu?Gly?Thr?Met?Glu?Leu?Arg?Glu?Gly?His?Ile?Asp?Gln?Phe

230 235 240 245

ggt?cac?aag?acc?ttc?acg?gga?att?gga?cag?cag?atc?gct?gat?gag?atc 883

Gly?His?Lys?Thr?Phe?Thr?Gly?Ile?Gly?Gln?Gln?Ile?Ala?Asp?Glu?Ile

250 255 260

cac?gtg?cgc?ctc?ggc?cac?gat?gtt?cgt?acg?acc?gtt?ctt?ggc?cac?att 931

His?Val?Arg?Leu?Gly?His?Asp?Val?Arg?Thr?Thr?Val?Leu?Gly?His?Ile

265 270 275

caa?cgt?ggt?gga?acc?cca?act?gct?ttc?gac?cgt?gtt?ctg?gcc?act?cgt 979

Gln?Arg?Gly?Gly?Thr?Pro?Thr?Ala?Phe?Asp?Arg?Val?Leu?Ala?Thr?Arg

280 285 290

tat?ggt?gtt?cgt?gca?gct?cgt?gcg?tgc?cat?gag?gga?agc?ttt?gac?aag 1027

Tyr?Gly?Val?Arg?Ala?Ala?Arg?Ala?Cys?His?Glu?Gly?Ser?Phe?Asp?Lys

295 300 305

gtt?gtt?gct?ttg?aag?ggt?gag?agc?att?gag?atg?atc?acc?ttt?gaa?gaa 1075

Val?Val?Ala?Leu?Lys?Gly?Glu?Ser?Ile?Glu?Met?Ile?Thr?Phe?Glu?Glu

310 315 320 325

gca?gtc?gga?acc?ttg?aag?gaa?gtt?cca?ttc?gaa?cgc?tgg?gtt?act?gcc 1123

Ala?Val?Gly?Thr?Leu?Lys?Glu?Val?Pro?Phe?Glu?Arg?Trp?Val?Thr?Ala

330 335 340

cag?gca?atg?ttt?gga?tagtttttcg?ggcttttatc?aac 1161

Gln?Ala?Met?Phe?Gly

345

<210>54

<211>346

<212>PRT

＜213〉Corynebacterium glutamicum

<400>54

Met?Glu?Asp?Met?Arg?Ile?Ala?Thr?Leu?Thr?Ser?Gly?Gly?Asp?Cys?Pro

1 5 10 15

Gly?Leu?Asn?Ala?Val?Ile?Arg?Gly?Ile?Val?Arg?Thr?Ala?Ser?Asn?Glu

20 25 30

Phe?Gly?Ser?Thr?Val?Val?Gly?Tyr?Gln?Asp?Gly?Trp?Glu?Gly?Leu?Leu

35 40 45

Gly?Asp?Arg?Arg?Val?Gln?Leu?Tyr?Asp?Asp?Glu?Asp?Ile?Asp?Arg?Ile

50 55 60

Leu?Leu?Arg?Gly?Gly?Thr?Ile?Leu?Gly?Thr?Gly?Arg?Leu?His?Pro?Asp

65 70 75 80

Lys?Phe?Lys?Ala?Gly?Ile?Asp?Gln?Ile?Lys?Ala?Asn?Leu?Glu?Asp?Ala

85 90 95

Gly?Ile?Asp?Ala?Leu?Ile?Pro?Ile?Gly?Gly?Glu?Gly?Thr?Leu?Lys?Gly

100 105 110

Ala?Lys?Trp?Leu?Ser?Asp?Asn?Gly?Ile?Pro?Val?Val?Gly?Val?Pro?Lys

115 120 125

Thr?Ile?Asp?Asn?Asp?Val?Asn?Gly?Thr?Asp?Phe?Thr?Phe?Gly?Phe?Asp

130 135 140

Thr?Ala?Val?Ala?Val?Ala?Thr?Asp?Ala?Val?Asp?Arg?Leu?His?Thr?Thr

145 150 155 160

Ala?Glu?Ser?His?Asn?Arg?Val?Met?Ile?Val?Glu?Val?Met?Gly?Arg?His

165 170 175

Val?Gly?Trp?Ile?Ala?Leu?His?Ala?Gly?Met?Ala?Gly?Gly?Ala?His?Tyr

180 185 190

Thr?Val?Ile?Pro?Glu?Val?Pro?Phe?Asp?Ile?Ala?Glu?Ile?Cys?Lys?Ala

195 200 205

Met?Glu?Arg?Arg?Phe?Gln?Met?Gly?Glu?Lys?Tyr?Gly?Ile?Ile?Val?Val

210 215 220

Ala?Glu?Gly?Ala?Leu?Pro?Arg?Glu?Gly?Thr?Met?Glu?Leu?Arg?Glu?Gly

225 230 235 240

His?Ile?Asp?Gln?Phe?Gly?His?Lys?Thr?Phe?Thr?Gly?Ile?Gly?Gln?Gln

245 250 255

Ile?Ala?Asp?Glu?Ile?His?Val?Arg?Leu?Gly?His?Asp?Val?Arg?Thr?Thr

260 265 270

Val?Leu?Gly?His?Ile?Gln?Arg?Gly?Gly?Thr?Pro?Thr?Ala?Phe?Asp?Arg

275 280 285

Val?Leu?Ala?Thr?Arg?Tyr?Gly?Val?Arg?Ala?Ala?Arg?Ala?Cys?His?Glu

290 295 300

Gly?Ser?Phe?Asp?Lys?Val?Val?Ala?Leu?Lys?Gly?Glu?Ser?Ile?Glu?Met

305 310 315 320

Ile?Thr?Phe?Glu?Glu?Ala?Val?Gly?Thr?Leu?Lys?Glu?Val?Pro?Phe?Glu

325 330 335

Arg?Trp?Val?Thr?Ala?Gln?Ala?Met?Phe?Gly

340 345

<210>55

<211>1083

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1060)

<223>RXA01243

<400>55

gcgcaatcag?cgatatcgat?gtggtggtca?ccgatgcggg?tgcaccagca?agtttcgttg?60

agcagttgcg?agaacgcgat?gtagaagttg?tgattgcaga?atg?att?ctt?aca?gtc 115

Met?Ile?Leu?Thr?Val

1 5

act?gca?agt?ccg?tat?ctg?ttg?agc?acc?aat?gag?ctt?gac?ggc?acc?atc 163

Thr?Ala?Ser?Pro?Tyr?Leu?Leu?Ser?Thr?Asn?Glu?Leu?Asp?Gly?Thr?Ile

10 15 20

gaa?att?ggc?gaa?gca?aac?aaa?arc?cgg?cag?gtt?tcc?act?gtt?gcc?ggt 211

Glu?Ile?Gly?Glu?Ala?Asn?Lys?Ile?Arg?Gln?Val?Ser?Thr?Val?Ala?Gly

25 30 35

ggt?ttt?ggc?acc?ggt?gtg?gct?gcc?acc?ttg?ttt?tat?ggc?ggc?aat?gaa 259

Gly?Phe?Gly?Thr?Gly?Val?Ala?Ala?Thr?Leu?Phe?Tyr?Gly?Gly?Asn?Glu

40 45 50

act?ttt?gca?gtt?ttt?ccc?gct?cca?gaa?atc?tct?cat?tac?atg?cgc?ctg 307

Thr?Phe?Ala?Val?Phe?Pro?Ala?Pro?Glu?Ile?Ser?His?Tyr?Met?Arg?Leu

55 60 65

gtg?acg?ttt?gct?ggg?ttg?cct?cat?gaa?att?att?ccg?gtg?gca?ggt?ccc 355

Val?Thr?Phe?Ala?Gly?Leu?Pro?His?Glu?Ile?Ile?Pro?Val?Ala?Gly?Pro

70 75 80 85

atc?ccc?atg?cat?ttg?acc?atg?cgt?gat?gca?gag?ggc?aat?gag?act?aag 403

Ile?Pro?Met?His?Leu?Thr?Met?Arg?Asp?Ala?Glu?Gly?Asn?Glu?Thr?Lys

90 95 100

ttc?aaa?gac?tcc?ccc?atg?cct?ttg?gat?gtg?tcc?cag?ttg?gca?att?ctt 451

Phe?Lys?Asp?Ser?Pro?Met?Pro?Leu?Asp?Val?Ser?Gln?Leu?Ala?Ile?Leu

105 110 115

cgt?gat?cta?gtg?gtg?cgt?cga?gcc?gaa?gat?gcc?gcg?tgg?gtg?ttg?ttg 499

Arg?Asp?Leu?Val?Val?Arg?Arg?Ala?Glu?Asp?Ala?Ala?Trp?Val?Leu?Leu

120 125 130

ggt?ggc?aat?ttg?ccg?tct?atc?gcg?cct?gct?gcg?tgg?ttt?gtg?gat?gtg 547

Gly?Gly?Asn?Leu?Pro?Ser?Ile?Ala?Pro?Ala?Ala?Trp?Phe?Val?Asp?Val

135 140 145

gtg?aga?tca?ctt?cgc?ttg?tac?cac?cct?cat?gtg?aag?gta?gct?atc?gca 595

Val?Arg?Ser?Leu?Arg?Leu?Tyr?His?Pro?His?Val?Lys?Val?Ala?Ile?Ala

150 155 160 165

gca?act?ggt?gct?gcg?ttg?cgt?gcg?gtt?att?cga?cag?ctt?gca?gct?acg 643

Ala?Thr?Gly?Ala?Ala?Leu?Arg?Ala?Val?Ile?Arg?Gln?Leu?Ala?Ala?Thr

170 175 180

tcc?ccg?gat?gcg?ctg?att?gtg?gct?gcg?gaa?gaa?atc?gaa?att?gcc?act 691

Ser?Pro?Asp?Ala?Leu?Ile?Val?Ala?Ala?Glu?Glu?Ile?Glu?Ile?Ala?Thr

185 190 195

gga?tta?gaa?ccc?aaa?acc?ttg?aga?ggt?cca?tgg?gta?gag?gga?gat?ctc 739

Gly?Leu?Glu?Pro?Lys?Thr?Leu?Arg?Gly?Pro?Trp?Val?Glu?Gly?Asp?Leu

200 205 210

tcc?ccg?act?gtg?gcg?gca?gcg?cgc?gct?tta?att?gat?agc?ggt?gtc?acc 787

Ser?Pro?Thr?Val?Ala?Ala?Ala?Arg?Ala?Leu?Ile?Asp?Ser?Gly?Val?Thr

215 220 225

gag?gtg?ttg?gtt?acc?aac?aag?cgg?acg?gaa?tct?ttg?tat?gtt?tcc?gag 835

Glu?Val?Leu?Val?Thr?Asn?Lys?Arg?Thr?Glu?Ser?Leu?Tyr?Val?Ser?Glu

230 235 240 245

tct?gaa?tca?ctg?tta?gcc?agc?tac?gac?agc?acc?cct?ggt?aag?cag?ggc 883

Ser?Glu?Ser?Leu?Leu?Ala?Ser?Tyr?Asp?Ser?Thr?Pro?Gly?Lys?Gln?Gly

250 255 260

gtg?aat?tgg?cgg?gaa?tct?ttt?act?gca?gga?ttc?ttg?gca?gca?tcc?aat 931

Val?Asn?Trp?Arg?Glu?Ser?Phe?Thr?Ala?Gly?Phe?Leu?Ala?Ala?Ser?Asn

265 270 275

gat?gga?aaa?tcc?act?gag?gac?agc?gtg?atc?aac?gcg?gtt?gct?tac?gcc 979

Asp?Gly?Lys?Ser?Thr?Glu?Asp?Ser?Val?Ile?Asn?Ala?Val?Ala?Tyr?Ala

280 285 290

aac?gct?gaa?ggc?agt?gag?tgg?gac?aac?tac?att?ccc?aca?ccc?gat?aag 1027

Asn?Ala?Glu?Gly?Ser?Glu?Trp?Asp?Asn?Tyr?Ile?Pro?Thr?Pro?Asp?Lys

295 300 305

ctt?cgg?gcg?gag?cac?gtg?gtc?atc?aaa?tcg?ctt?tagaccacgc?aaaaagcctc?1080

Leu?Arg?Ala?Glu?His?Val?Val?Ile?Lys?Ser?Leu

310 315 320

aaa 1083

<210>56

<211>320

<212>PRT

＜213〉Corynebacterium glutamicum

<400>56

Met?Ile?Leu?Thr?Val?Thr?Ala?Ser?Pro?Tyr?Leu?Leu?Ser?Thr?Asn?Glu

1 5 10 15

Leu?Asp?Gly?Thr?Ile?Glu?Ile?Gly?Glu?Ala?Asn?Lys?Ile?Arg?Gln?Val

20 25 30

Ser?Thr?Val?Ala?Gly?Gly?Phe?Gly?Thr?Gly?Val?Ala?Ala?Thr?Leu?Phe

35 40 45

Tyr?Gly?Gly?Asn?Glu?Thr?Phe?Ala?Val?Phe?Pro?Ala?Pro?Glu?Ile?Ser

50 55 60

His?Tyr?Met?Arg?Leu?Val?Thr?Phe?Ala?Gly?Leu?Pro?His?Glu?Ile?Ile

65 70 75 80

Pro?Val?Ala?Gly?Pro?Ile?Pro?Met?His?Leu?Thr?Met?Arg?Asp?Ala?Glu

85 90 95

Gly?Asn?Glu?Thr?Lys?Phe?Lys?Asp?Ser?Pro?Met?Pro?Leu?Asp?Val?Ser

100 105 110

Gln?Leu?Ala?Ile?Leu?Arg?Asp?Leu?Val?Val?Arg?Arg?Ala?Glu?Asp?Ala

115 120 125

Ala?Trp?Val?Leu?Leu?Gly?Gly?Asn?Leu?Pro?Ser?Ile?Ala?Pro?Ala?Ala

130 135 140

Trp?Phe?Val?Asp?Val?Val?Arg?Ser?Leu?Arg?Leu?Tyr?His?Pro?His?Val

145 150 155 160

Lys?Val?Ala?Ile?Ala?Ala?Thr?Gly?Ala?Ala?Leu?Arg?Ala?Val?Ile?Arg

165 170 175

Gln?Leu?Ala?Ala?Thr?Ser?Pro?Asp?Ala?Leu?Ile?Val?Ala?Ala?Glu?Glu

180 185 190

Ile?Glu?Ile?Ala?Thr?Gly?Leu?Glu?Pro?Lys?Thr?Leu?Arg?Gly?Pro?Trp

195 200 205

Val?Glu?Gly?Asp?Leu?Ser?Pro?Thr?Val?Ala?Ala?Ala?Arg?Ala?Leu?Ile

210 215 220

Asp?Ser?Gly?Val?Thr?Glu?Val?Leu?Val?Thr?Asn?Lys?Arg?Thr?Glu?Ser

225 230 235 240

Leu?Tyr?Val?Ser?Glu?Ser?Glu?Ser?Leu?Leu?Ala?Ser?Tyr?Asp?Ser?Thr

245 250 255

Pro?Gly?Lys?Gln?Gly?Val?Asn?Trp?Arg?Glu?Ser?Phe?Thr?Ala?Gly?Phe

260 265 270

Leu?Ala?Ala?Ser?Asn?Asp?Gly?Lys?Ser?Thr?Glu?Asp?Ser?Val?Ile?Asn

275 280 285

Ala?Val?Ala?Tyr?Ala?Asn?Ala?Glu?Gly?Ser?Glu?Trp?Asp?Asn?Tyr?Ile

290 295 300

Pro?Thr?Pro?Asp?Lys?Leu?Arg?Ala?Glu?His?Val?Val?Ile?Lys?Ser?Leu

305 310 315 320

<210>57

<211>1113

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1090)

<223>RXA01882

<400>57

accctttttc?caccttggct?gattttgatg?cccttgttac?cgatgaccac?acgctagatt?60

ttccagtttt?gcccgaccac?aactttcagg?tggtaacccc?atg?atc?atc?aca?ttc 115

Met?Ile?Ile?Thr?Phe

1 5

acc?cca?aac?ccg?agt?att?gat?tcc?acg?ctg?tcg?ctc?ggc?gaa?gag?ctc 163

Thr?Pro?Asn?Pro?Ser?Ile?Asp?Ser?Thr?Leu?Ser?Leu?Gly?Glu?Glu?Leu

10 15 20

tcc?cgt?gga?tcc?gtc?caa?cga?ctt?gat?tcc?gtc?acc?gct?gtc?gca?ggt 211

Ser?Arg?Gly?Ser?Val?Gln?Arg?Leu?Asp?Ser?Val?Thr?Ala?Val?Ala?Gly

25 30 35

ggt?aaa?ggc?atc?aat?gtc?gcc?cac?gct?gtc?ttg?ctt?gcg?ggc?ttt?gaa 259

Gly?Lys?Gly?Ile?Asn?Val?Ala?His?Ala?Val?Leu?Leu?Ala?Gly?Phe?Glu

40 45 50

acc?ttg?gct?gtg?ttc?cca?gcc?ggc?aag?ctc?gac?ccc?ttc?gtc?cca?ctg 307

Thr?Leu?Ala?Val?Phe?Pro?Ala?Gly?Lys?Leu?Asp?Pro?Phe?Val?Pro?Leu

55 60 65

gtc?cgc?gac?atc?ggc?ttg?ccc?gtg?gaa?act?gtt?gtg?atc?aac?aag?aac 355

Val?Arg?Asp?Ile?Gly?Leu?Pro?Val?Glu?Thr?Val?Val?Ile?Asn?Lys?Asn

70 75 80 85

gtc?cgc?acc?aac?acc?aca?gtc?acc?gaa?ccg?gac?ggc?acc?acc?acc?aag 403

Val?Arg?Thr?Asn?Thr?Thr?Val?Thr?Glu?Pro?Asp?Gly?Thr?Thr?Thr?Lys

90 95 100

ctc?aac?ggc?ccc?ggc?gcg?ccg?ctc?agc?gag?cag?aag?ctc?cgt?agc?ttg 451

Leu?Asn?Gly?Pro?Gly?Ala?Pro?Leu?Ser?Glu?Gln?Lys?Leu?Arg?Ser?Leu

105 110 115

gaa?aag?gtg?ctt?atc?gac?gcg?ctc?cgc?ccc?gaa?gtc?acc?tgg?gtt?gtc 499

Glu?Lys?Val?Leu?Ile?Asp?Ala?Leu?Arg?Pro?Glu?Val?Thr?Trp?Val?Val

120 125 130

ctg?gcg?ggc?tcg?ctg?cca?cca?ggg?gca?cca?gtt?gac?tgg?tac?gcg?cgt 547

Leu?Ala?Gly?Ser?Leu?Pro?Pro?Gly?Ala?Pro?Val?Asp?Trp?Tyr?Ala?Arg

135 140 145

ctc?acc?gcg?ttg?atc?cat?tca?gca?cgc?cct?gac?gtt?cgc?gtg?gct?gtc 595

Leu?Thr?Ala?Leu?Ile?His?Ser?Ala?Arg?Pro?Asp?Val?Arg?Val?Ala?Val

150 155 160 165

gat?acc?tca?gac?aag?cca?ctg?atg?gcg?ttg?ggc?gag?agc?ttg?gat?aca 643

Asp?Thr?Ser?Asp?Lys?Pro?Leu?Met?Ala?Leu?Gly?Glu?Ser?Leu?Asp?Thr

170 175 180

cct?ggc?gct?gct?ccg?aac?ctg?att?aag?cca?aat?ggt?ctg?gaa?ctg?ggc 691

Pro?Gly?Ala?Ala?Pro?Asn?Leu?Ile?Lys?Pro?Asn?Gly?Leu?Glu?Leu?Gly

185 190 195

cag?ctg?gct?aac?act?gat?ggt?gaa?gag?ctg?gag?gcg?cgt?gct?gcg?caa 739

Gln?Leu?Ala?Asn?Thr?Asp?Gly?Glu?Glu?Leu?Glu?Ala?Arg?Ala?Ala?Gln

200 205 210

ggc?gat?tac?gac?gcc?atc?atc?gca?gct?gcg?gac?gta?ctg?gtt?aac?cgt 787

Gly?Asp?Tyr?Asp?Ala?Ile?Ile?Ala?Ala?Ala?Asp?Val?Leu?Val?Asn?Arg

215 220 225

ggc?atc?gaa?cag?gtg?ctt?gtc?acc?ttg?ggt?gcc?gca?gga?gcg?gtg?ttg 835

Gly?Ile?Glu?Gln?Val?Leu?Val?Thr?Leu?Gly?Ala?Ala?Gly?Ala?Val?Leu

230 235 240 245

gtc?aac?gca?gaa?ggt?gcg?tgg?act?gct?act?tct?cca?aag?att?gat?gtt 883

Val?Asn?Ala?Glu?Gly?Ala?Trp?Thr?Ala?Thr?Ser?Pro?Lys?Ile?Asp?Val

250 255 260

gta?tcc?acc?gtt?gga?gct?gga?gac?tgt?gct?ctt?gca?ggt?ttt?gtt?atg 931

Val?Ser?Thr?Val?Gly?Ala?Gly?Asp?Cys?Ala?Leu?Ala?Gly?Phe?Val?Met

265 270 275

gca?cgt?tcc?cag?aag?aaa?aca?ctg?gag?gaa?tct?ctg?ctg?aat?gcc?gtg 979

Ala?Arg?Ser?Gln?Lys?Lys?Thr?Leu?Glu?Glu?Ser?Leu?Leu?Asn?Ala?Val

280 285 290

tct?tac?ggc?tcg?act?gcg?gcg?tct?ctt?cct?ggc?act?acc?att?cct?cgt 1027

Ser?Tyr?Gly?Ser?Thr?Ala?Ala?Ser?Leu?Pro?Gly?Thr?Thr?Ile?Pro?Arg

295 300 305

cct?gac?caa?ctc?gcc?aca?gct?ggt?gca?acg?gtc?acc?caa?gtc?aaa?gga 1075

Pro?Asp?Gln?Leu?Ala?Thr?Ala?Gly?Ala?Thr?Val?Thr?Gln?Val?Lys?Gly

310 315 320 325

ttg?aaa?gaa?tca?gca?tgaatagcgt?aaataattcc?tcg 1113

Leu?Lys?Glu?Ser?Ala

330

<210>58

<211>330

<212>PRT

＜213〉Corynebacterium glutamicum

<400>58

Met?Ile?Ile?Thr?Phe?Thr?Pro?Asn?Pro?Ser?Ile?Asp?Ser?Thr?Leu?Ser

1 5 10 15

Leu?Gly?Glu?Glu?Leu?Ser?Arg?Gly?Ser?Val?Gln?Arg?Leu?Asp?Ser?Val

20 25 30

Thr?Ala?Val?Ala?Gly?Gly?Lys?Gly?Ile?Asn?Val?Ala?His?Ala?Val?Leu

35 40 45

Leu?Ala?Gly?Phe?Glu?Thr?Leu?Ala?Val?Phe?Pro?Ala?Gly?Lys?Leu?Asp

50 55 60

Pro?Phe?Val?Pro?Leu?Val?Arg?Asp?Ile?Gly?Leu?Pro?Val?Glu?Thr?Val

65 70 75 80

Val?Ile?Asn?Lys?Asn?Val?Arg?Thr?Asn?Thr?Thr?Val?Thr?Glu?Pro?Asp

85 90 95

Gly?Thr?Thr?Thr?Lys?Leu?Asn?Gly?Pro?Gly?Ala?Pro?Leu?Ser?Glu?Gln

100 105 110

Lys?Leu?Arg?Ser?Leu?Glu?Lys?Val?Leu?Ile?Asp?Ala?Leu?Arg?Pro?Glu

115 120 125

Val?Thr?Trp?Val?Val?Leu?Ala?Gly?Ser?Leu?Pro?Pro?Gly?Ala?Pro?Val

130 135 140

Asp?Trp?Tyr?Ala?Arg?Leu?Thr?Ala?Leu?Ile?His?Ser?Ala?Arg?Pro?Asp

145 150 155 160

Val?Arg?Val?Ala?Val?Asp?Thr?Ser?Asp?Lys?Pro?Leu?Met?Ala?Leu?Gly

165 170 175

Glu?Ser?Leu?Asp?Thr?Pro?Gly?Ala?Ala?Pro?Asn?Leu?Ile?Lys?Pro?Asn

180 185 190

Gly?Leu?Glu?Leu?Gly?Gln?Leu?Ala?Asn?Thr?Asp?Gly?Glu?Glu?Leu?Glu

195 200 205

Ala?Arg?Ala?Ala?Gln?Gly?Asp?Tyr?Asp?Ala?Ile?Ile?Ala?Ala?Ala?Asp

210 215 220

Val?Leu?Val?Asn?Arg?Gly?Ile?Glu?Gln?Val?Leu?Val?Thr?Leu?Gly?Ala

225 230 235 240

Ala?Gly?Ala?Val?Leu?Val?Asn?Ala?Glu?Gly?Ala?Trp?Thr?Ala?Thr?Ser

245 250 255

Pro?Lys?Ile?Asp?Val?Val?Ser?Thr?Val?Gly?Ala?Gly?Asp?Cys?Ala?Leu

260 265 270

Ala?Gly?Phe?Val?Met?Ala?Arg?Ser?Gln?Lys?Lys?Thr?Leu?Glu?Glu?Ser

275 280 285

Leu?Leu?Asn?Ala?Val?Ser?Tyr?Gly?Ser?Thr?Ala?Ala?Ser?Leu?Pro?Gly

290 295 300

Thr?Thr?Ile?Pro?Arg?Pro?Asp?Gln?Leu?Ala?Thr?Ala?Gly?Ala?Thr?Val

305 310 315 320

Thr?Gln?Val?Lys?Gly?Leu?Lys?Glu?Ser?Ala

325 330

<210>59

<211>1155

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1132)

<223>RXA01702

<400>59

attgtgaatg?tgggattatc?ggttcgcgct?tcaccatgtt?tctgcatgat?gaaattacat?60

acatagttca?gtgacagtca?ccttttggag?gagacacctt?atg?cct?atc?gca?act 115

Met?Pro?Ile?Ala?Thr

1 5

ccc?gag?gtc?tat?aac?gag?atg?ctc?gat?cgt?gct?aag?gaa?ggc?gga?ttc 163

Pro?Glu?Val?Tyr?Asn?Glu?Met?Leu?Asp?Arg?Ala?Lys?Glu?Gly?Gly?Phe

10 15 20

gcc?ttc?cca?gcc?atc?aac?tgc?acc?tcc?tcg?gaa?acc?atc?aac?gca?gct 211

Ala?Phe?Pro?Ala?Ile?Asn?Cys?Thr?Ser?Ser?Glu?Thr?Ile?Asn?Ala?Ala

25 30 35

ctc?aag?ggc?ttc?gca?gag?gct?gaa?tct?gac?gga?atc?atc?cag?ttc?tcc 259

Leu?Lys?Gly?Phe?Ala?Glu?Ala?Glu?Ser?Asp?Gly?Ile?Ile?Gln?Phe?Ser

40 45 50

acc?ggt?ggt?gca?gag?ttc?ggt?tcc?ggc?ctg?gca?gta?aag?aac?aag?gtc 307

Thr?Gly?Gly?Ala?Glu?Phe?Gly?Ser?Gly?Leu?Ala?Val?Lys?Asn?Lys?Val

55 60 65

aag?ggc?gca?gtt?gcg?ctt?gca?gcc?ttc?gcc?cac?gag?gca?gca?aag?agc 355

Lys?Gly?Ala?Val?Ala?Leu?Ala?Ala?Phe?Ala?His?Glu?Ala?Ala?Lys?Ser

70 75 80 85

tac?ggc?atc?aac?gtt?gct?ctg?cac?act?gac?cac?tgc?cag?aag?gaa?gtc 403

Tyr?Gly?Ile?Asn?Val?Ala?Leu?His?Thr?Asp?His?Cys?Gln?Lys?Glu?Val

90 95 100

ctg?gac?gag?tac?gtc?cgc?cca?ctg?ctg?gct?atc?tcc?cag?gag?cgc?gtc 451

Leu?Asp?Glu?Tyr?Val?Arg?Pro?Leu?Leu?Ala?Ile?Ser?Gln?Glu?Arg?Val

105 110 115

gac?cgc?ggc?gag?ctt?cca?ctg?ttc?cag?tcc?cac?atg?tgg?gat?ggt?tcc 499

Asp?Arg?Gly?Glu?Leu?Pro?Leu?Phe?Gln?Ser?His?Met?Trp?Asp?Gly?Ser

120 125 130

gct?gtc?cca?atc?gac?gag?aac?ctc?gaa?atc?gca?cag?gag?ctg?ctg?gct 547

Ala?Val?Pro?Ile?Asp?Glu?Asn?Leu?Glu?Ile?Ala?Gln?Glu?Leu?Leu?Ala

135 140 145

aag?gcc?aag?gca?gcg?aac?atc?atc?ttg?gaa?gtt?gag?atc?ggt?gtt?gtc 595

Lys?Ala?Lys?Ala?Ala?Asn?Ile?Ile?Leu?Glu?Val?Glu?Ile?Gly?Val?Val

150 155 160 165

ggt?ggc?gaa?gaa?gac?ggc?gtt?gag?gct?aag?gct?ggc?gca?aac?ctc?tac 643

Gly?Gly?Glu?Glu?Asp?Gly?Val?Glu?Ala?Lys?Ala?Gly?Ala?Asn?Leu?Tyr

170 175 180

acc?tcc?cca?gaa?gac?ttt?gag?aag?acc?atc?gat?gca?atc?ggc?acc?ggt 691

Thr?Ser?Pro?Glu?Asp?Phe?Glu?Lys?Thr?Ile?Asp?Ala?Ile?Gly?Thr?Gly

185 190 195

gag?aag?ggc?cgc?tac?ctg?cta?gca?gct?acc?ttc?ggt?aac?gtc?cac?ggc 739

Glu?Lys?Gly?Arg?Tyr?Leu?Leu?Ala?Ala?Thr?Phe?Gly?Asn?Val?His?Gly

200 205 210

gtt?tac?aag?cca?ggc?aac?gtc?aag?ctg?cgc?cca?gag?gtc?ctc?ctt?gag 787

Val?Tyr?Lys?Pro?Gly?Asn?Val?Lys?Leu?Arg?Pro?Glu?Val?Leu?Leu?Glu

215 220 225

ggc?cag?cag?gtt?gca?cgc?aag?aag?ctt?gga?ctt?gca?gac?gac?gca?ctt 835

Gly?Gln?Gln?Val?Ala?Arg?Lys?Lys?Leu?Gly?Leu?Ala?Asp?Asp?Ala?Leu

230 235 240 245

cca?ttc?gac?ttc?gtc?ttc?cac?ggt?ggc?tca?ggc?tcc?gag?aag?gaa?aag 883

Pro?Phe?Asp?Phe?Val?Phe?His?Gly?Gly?Ser?Gly?Ser?Glu?Lys?Glu?Lys

250 255 260

atc?gaa?gag?gcg?ctg?acc?tac?ggc?gtc?atc?aag?atg?aac?gtt?gat?act 931

Ile?Glu?Glu?Ala?Leu?Thr?Tyr?Gly?Val?Ile?Lys?Met?Asn?Val?Asp?Thr

265 270 275

gac?acc?cag?tac?gca?ttc?acc?cgc?cca?atc?gtc?tcc?cac?atg?ttt?gag 979

Asp?Thr?Gln?Tyr?Ala?Phe?Thr?Arg?Pro?Ile?Val?Ser?His?Met?Phe?Glu

280 285 290

aac?tac?aac?ggc?gtt?ctc?aag?atc?gac?ggc?gag?gtc?gga?aac?aag?aag 1027

Asn?Tyr?Asn?Gly?Val?Leu?Lys?Ile?Asp?Gly?Glu?Val?Gly?Asn?Lys?Lys

295 300 305

gct?tac?gac?cca?cgc?tct?tac?atg?aag?aag?gct?gag?cag?agc?atg?tct 1075

Ala?Tyr?Asp?Pro?Arg?Ser?Tyr?Met?Lys?Lys?Ala?Glu?Gln?Ser?Met?Ser

310 315 320 325

gag?cgc?att?atc?gag?tct?tgc?cag?gac?ctc?aag?tct?gtt?gga?aag?acc 1123

Glu?Arg?Ile?Ile?Glu?Ser?Cys?Gln?Asp?Leu?Lys?Ser?Val?Gly?Lys?Thr

330 335 340

acc?tct?aag?taatctcagc?agttaaaaag?ggc 1155

Thr?Ser?Lys

<210>60

<211>344

<212>PRT

＜213〉Corynebacterium glutamicum

<400>60

Met?Pro?Ile?Ala?Thr?Pro?Glu?Val?Tyr?Asn?Glu?Met?Leu?Asp?Arg?Ala

1 5 10 15

Lys?Glu?Gly?Gly?Phe?Ala?Phe?Pro?Ala?Ile?Asn?Cys?Thr?Ser?Ser?Glu

20 25 30

Thr?Ile?Asn?Ala?Ala?Leu?Lys?Gly?Phe?Ala?Glu?Ala?Glu?Ser?Asp?Gly

35 40 45

Ile?Ile?Gln?Phe?Ser?Thr?Gly?Gly?Ala?Glu?Phe?Gly?Ser?Gly?Leu?Ala

50 55 60

Val?Lys?Asn?Lys?Val?Lys?Gly?Ala?Val?Ala?Leu?Ala?Ala?Phe?Ala?His

65 70 75 80

Glu?Ala?Ala?Lys?Ser?Tyr?Gly?Ile?Asn?Val?Ala?Leu?His?Thr?Asp?His

85 90 95

Cys?Gln?Lys?Glu?Val?Leu?Asp?Glu?Tyr?Val?Arg?Pro?Leu?Leu?Ala?Ile

100 105 110

Ser?Gln?Glu?Arg?Val?Asp?Arg?Gly?Glu?Leu?Pro?Leu?Phe?Gln?Ser?His

115 120 125

Met?Trp?Asp?Gly?Ser?Ala?Val?Pro?Ile?Asp?Glu?Asn?Leu?Glu?Ile?Ala

130 135 140

Gln?Glu?Leu?Leu?Ala?Lys?Ala?Lys?Ala?Ala?Asn?Ile?Ile?Leu?Glu?Val

145 150 155 160

Glu?Ile?Gly?Val?Val?Gly?Gly?Glu?Glu?Asp?Gly?Val?Glu?Ala?Lys?Ala

165 170 175

Gly?Ala?Asn?Leu?Tyr?Thr?Ser?Pro?Glu?Asp?Phe?Glu?Lys?Thr?Ile?Asp

180 185 190

Ala?Ile?Gly?Thr?Gly?Glu?Lys?Gly?Arg?Tyr?Leu?Leu?Ala?Ala?Thr?Phe

195 200 205

Gly?Asn?Val?His?Gly?Val?Tyr?Lys?Pro?Gly?Asn?Val?Lys?Leu?Arg?Pro

210 215 220

Glu?Val?Leu?Leu?Glu?Gly?Gln?Gln?Val?Ala?Arg?Lys?Lys?Leu?Gly?Leu

225 230 235 240

Ala?Asp?Asp?Ala?Leu?Pro?Phe?Asp?Phe?Val?Phe?His?Gly?Gly?Ser?Gly

245 250 255

Ser?Glu?Lys?Glu?Lys?Ile?Glu?Glu?Ala?Leu?Thr?Tyr?Gly?Val?Ile?Lys

260 265 270

Met?Asn?Val?Asp?Thr?Asp?Thr?Gln?Tyr?Ala?Phe?Thr?Arg?Pro?Ile?Val

275 280 285

Ser?His?Met?Phe?Glu?Asn?Tyr?Asn?Gly?Val?Leu?Lys?Ile?Asp?Gly?Glu

290 295 300

Val?Gly?Asn?Lys?Lys?Ala?Tyr?Asp?Pro?Arg?Ser?Tyr?Met?Lys?Lys?Ala

305 310 315 320

Glu?Gln?Ser?Met?Ser?Glu?Arg?Ile?Ile?Glu?Ser?Cys?Gln?Asp?Leu?Lys

325 330 335

Ser?Val?Gly?Lys?Thr?Thr?Ser?Lys

340

<210>61

<211>900

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(877)

<223>RXA02258

<400>61

cgttgcaatt?ctcgctcagt?aaatccgaca?cggccctttg?ttagaaaaca?aaacataaag?60

ggccaccggg?aaactttttt?aagaaaggtg?tgtttcacac?atg?gca?cgt?aag?cca 115

Met?Ala?Arg?Lys?Pro

1 5

ctt?atc?gct?ggt?aac?tgg?aag?atg?aac?ctg?gat?cac?cag?cag?gca?atc 163

Leu?Ile?Ala?Gly?Asn?Trp?Lys?Met?Asn?Leu?Asp?His?Gln?Gln?Ala?Ile

10 15 20

ggc?act?gtt?cag?aag?ctt?gca?ttc?gcc?ctt?cca?aag?gaa?tac?ttc?gag 211

Gly?Thr?Val?Gln?Lys?Leu?Ala?Phe?Ala?Leu?Pro?Lys?Glu?Tyr?Phe?Glu

25 30 35

aag?gtt?gac?gtt?gca?gtc?acc?gtt?cct?ttc?act?gac?atc?cgc?tcc?gtc 259

Lys?Val?Asp?Val?Ala?Val?Thr?Val?Pro?Phe?Thr?Asp?Ile?Arg?Ser?Val

40 45 50

cag?act?ctc?gtt?gag?ggc?gac?aag?ctt?gag?gtc?act?ttc?ggt?gct?cag 307

Gln?Thr?Leu?Val?Glu?Gly?Asp?Lys?Leu?Glu?Val?Thr?Phe?Gly?Ala?Gln

55 60 65

gac?gtc?tcc?cag?cac?gag?tcc?ggt?gcg?tac?acc?ggt?gaa?gtt?tct?gca 355

Asp?Val?Ser?Gln?His?Glu?Ser?Gly?Ala?Tyr?Thr?Gly?Glu?Val?Ser?Ala

70 75 80 85

agc?atg?ctg?gca?aag?ttg?aac?tgc?tct?tgg?gtt?gtc?gtt?gga?cac?tcc 403

Ser?Met?Leu?Ala?Lys?Leu?Asn?Cys?Ser?Trp?Val?Val?Val?Gly?His?Ser

90 95 100

gag?cgc?cgc?gag?tac?cac?aac?gag?tct?gat?gag?ttg?gtt?gct?gcg?aag 451

Glu?Arg?Arg?Glu?Tyr?His?Asn?Glu?Ser?Asp?Glu?Leu?Val?Ala?Ala?Lys

105 110 115

gca?aag?gca?gct?ctg?tcc?aac?ggc?atc?agc?ccg?atc?gtc?tgc?gtt?ggt 499

Ala?Lys?Ala?Ala?Leu?Ser?Asn?Gly?Ile?Ser?Pro?Ile?Val?Cys?Val?Gly

120 125 130

gag?cca?ctg?gaa?atc?cgt?gaa?gct?ggc?acc?cac?gtt?gag?tac?gtc?gtc 547

Glu?Pro?Leu?Glu?Ile?Arg?Glu?Ala?Gly?Thr?His?Val?Glu?Tyr?Val?Val

135 140 145

gag?cag?acc?cgt?aag?tcc?ctt?gct?ggc?ctg?gat?gct?gct?gag?ctg?gcc 595

Glu?Gln?Thr?Arg?Lys?Ser?Leu?Ala?Gly?Leu?Asp?Ala?Ala?Glu?Leu?Ala

150 155 160 165

aac?acc?gtt?atc?gcg?tat?gag?cca?gtg?tgg?gct?atc?ggc?acc?ggt?aag 643

Asn?Thr?Val?Ile?Ala?Tyr?Glu?Pro?Val?Trp?Ala?Ile?Gly?Thr?Gly?Lys

170 175 180

gtt?gct?tcc?gca?gct?gac?gct?cag?gaa?gtg?tgc?aag?gct?atc?cgc?ggt 691

Val?Ala?Ser?Ala?Ala?Asp?Ala?Gln?Glu?Val?Cys?Lys?Ala?Ile?Arg?Gly

185 190 195

ctg?atc?gtg?gag?ctt?gca?ggc?gac?gag?gtc?gct?gag?ggc?ctg?cgt?att 739

Leu?Ile?Val?Glu?Leu?Ala?Gly?Asp?Glu?Val?Ala?Glu?Gly?Leu?Arg?Ile

200 205 210

ctt?tac?ggt?ggt?tct?gtt?aag?gca?gaa?acc?gtc?gct?gag?atc?gtc?ggt 787

Leu?Tyr?Gly?Gly?Ser?Val?Lys?Ala?Glu?Thr?Val?Ala?Glu?Ile?Val?Gly

215 220 225

cag?cct?gac?gtc?gac?ggc?gga?ctt?gtc?ggt?ggc?gct?tcc?ctc?gac?ggt 835

Gln?Pro?Asp?Val?Asp?Gly?Gly?Leu?Val?Gly?Gly?Ala?Ser?Leu?Asp?Gly

230 235 240 245

gaa?gca?ttc?gcc?aag?ctg?gct?gcc?aac?gct?gcg?agc?gtt?gct 877

Glu?Ala?Phe?Ala?Lys?Leu?Ala?Ala?Asn?Ala?Ala?Ser?Val?Ala

250 255

taaagtacag?agctttaaag?cac 900

<210>62

<211>259

<212>PRT

＜213〉Corynebacterium glutamicum

<400>62

Met?Ala?Arg?Lys?Pro?Leu?Ile?Ala?Gly?Asn?Trp?Lys?Met?Asn?Leu?Asp

1 5 10 15

His?Gln?Gln?Ala?Ile?Gly?Thr?Val?Gln?Lys?Leu?Ala?Phe?Ala?Leu?Pro

20 25 30

Lys?Glu?Tyr?Phe?Glu?Lys?Val?Asp?Val?Ala?Val?Thr?Val?Pro?Phe?Thr

35 40 45

Asp?Ile?Arg?Ser?Val?Gln?Thr?Leu?Val?Glu?Gly?Asp?Lys?Leu?Glu?Val

50 55 60

Thr?Phe?Gly?Ala?Gln?Asp?Val?Ser?Gln?His?Glu?Ser?Gly?Ala?Tyr?Thr

65 70 75 80

Gly?Glu?Val?Ser?Ala?Ser?Met?Leu?Ala?Lys?Leu?Asn?Cys?Ser?Trp?Val

85 90 95

Val?Val?Gly?His?Ser?Glu?Arg?Arg?Glu?Tyr?His?Asn?Glu?Ser?Asp?Glu

100 105 110

Leu?Val?Ala?Ala?Lys?Ala?Lys?Ala?Ala?Leu?Ser?Asn?Gly?Ile?Ser?Pro

115 120 125

Ile?Val?Cys?Val?Gly?Glu?Pro?Leu?Glu?Ile?Arg?Glu?Ala?Gly?Thr?His

130 135 140

Val?Glu?Tyr?Val?Val?Glu?Gln?Thr?Arg?Lys?Ser?Leu?Ala?Gly?Leu?Asp

145 150 155 160

Ala?Ala?Glu?Leu?Ala?Asn?Thr?Val?Ile?Ala?Tyr?Glu?Pro?Val?Trp?Ala

165 170 175

Ile?Gly?Thr?Gly?Lys?Val?Ala?Ser?Ala?Ala?Asp?Ala?Gln?Glu?Val?Cys

180 185 190

Lys?Ala?Ile?Arg?Gly?Leu?Ile?Val?Glu?Leu?Ala?Gly?Asp?Glu?Val?Ala

195 200 205

Glu?Gly?Leu?Arg?Ile?Leu?Tyr?Gly?Gly?Ser?Val?Lys?Ala?Glu?Thr?Val

210 215 220

Ala?Glu?Ile?Val?Gly?Gln?Pro?Asp?Val?Asp?Gly?Gly?Leu?Val?Gly?Gly

225 230 235 240

Ala?Ser?Leu?Asp?Gly?Glu?Ala?Phe?Ala?Lys?Leu?Ala?Ala?Asn?Ala?Ala

245 250 255

Ser?Val?Ala

<210>63

<211>1563

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1540)

<223>RXN01225

<400>63

tttgggctaa?tgttgggggg?agtgctttca?actatccacg?agagctgccc?agtgataaac?60

cccgggttaa?ccccacgcct?aagtcagtga?aggacttttt?atg?acg?cac?aac?cac 115

Met?Thr?His?Asn?His

1 5

aag?gac?tgg?aac?gat?cgc?att?gca?gtt?gcg?gag?gaa?atg?gtg?ccg?ttg 163

Lys?Asp?Trp?Asn?Asp?Arg?Ile?Ala?Val?Ala?Glu?Glu?Met?Val?Pro?Leu

10 15 20

atc?ggg?cgc?ctg?cac?cgc?aac?aac?aac?gtg?gtg?gtt?tcc?gta?ttc?ggt 211

Ile?Gly?Arg?Leu?His?Arg?Asn?Asn?Asn?Val?Val?Val?Ser?Val?Phe?Gly

25 30 35

cgt?ctc?ctt?gtg?aat?gtc?tca?gac?atc?gat?atc?atc?aag?tct?cac?cgc 259

Arg?Leu?Leu?Val?Asn?Val?Ser?Asp?Ile?Asp?Ile?Ile?Lys?Ser?His?Arg

40 45 50

tac?gcc?cgc?cac?atc?ata?tcc?aag?gaa?ctt?cca?ctg?gaa?agc?tcc?ttg 307

Tyr?Ala?Arg?His?Ile?Ile?Ser?Lys?Glu?Leu?Pro?Leu?Glu?Ser?Ser?Leu

55 60 65

gat?att?ttg?cgc?gaa?ctg?gta?gat?atg?aac?ctt?ggt?acc?gca?tcg?atc 355

Asp?Ile?Leu?Arg?Glu?Leu?Val?Asp?Met?Asn?Leu?Gly?Thr?Ala?Ser?Ile

70 75 80 85

gac?ctg?gga?cag?ctg?gcc?tac?agc?ttc?gaa?gaa?tcc?gaa?agc?acc?gac 403

Asp?Leu?Gly?Gln?Leu?Ala?Tyr?Ser?Phe?Glu?Glu?Ser?Glu?Ser?Thr?Asp

90 95 100

ctg?cgt?gcc?ttc?ctg?gag?gac?gct?ctc?gcg?ccg?gtc?att?ggt?gcg?gaa 451

Leu?Arg?Ala?Phe?Leu?Glu?Asp?Ala?Leu?Ala?Pro?Val?Ile?Gly?Ala?Glu

105 110 115

acc?gac?atc?aac?cca?act?gat?atc?gtg?ctg?tac?ggt?ttc?ggc?cgc?atc 499

Thr?Asp?Ile?Asn?Pro?Thr?Asp?Ile?Val?Leu?Tyr?Gly?Phe?Gly?Arg?Ile

120 125 130

ggt?cgc?ctg?ctg?gcc?cgc?atc?ctg?gtt?tcc?cgc?gag?gca?ctg?tat?gac 547

Gly?Arg?Leu?Leu?Ala?Arg?Ile?Leu?Val?Ser?Arg?Glu?Ala?Leu?Tyr?Asp

135 140 145

ggt?gct?cgt?ctg?cgc?gcc?atc?gtg?gtc?cgc?aaa?aat?ggt?gaa?gaa?gac 595

Gly?Ala?Arg?Leu?Arg?Ala?Ile?Val?Val?Arg?Lys?Asn?Gly?Glu?Glu?Asp

150 155 160 165

ctg?gtc?aag?cgc?gca?tcc?ttg?ctg?cgt?cgt?gat?tct?gtc?cac?ggt?gga 643

Leu?Val?Lys?Arg?Ala?Ser?Leu?Leu?Arg?Arg?Asp?Ser?Val?His?Gly?Gly

170 175 180

ttc?gat?ggc?acc?atc?acc?acc?gat?tat?gac?aac?aac?atc?atc?tgg?gcc 691

Phe?Asp?Gly?Thr?Ile?Thr?Thr?Asp?Tyr?Asp?Asn?Asn?Ile?Ile?Trp?Ala

185 190 195

aac?ggc?acc?cca?atc?aag?gtc?atc?tac?tcc?aat?gac?cca?gcc?acc?att 739

Asn?Gly?Thr?Pro?Ile?Lys?Val?Ile?Tyr?Ser?Asn?Asp?Pro?Ala?Thr?Ile

200 205 210

gat?tac?acc?gaa?tac?ggc?atc?aat?gac?gcc?gtc?gtg?gta?gac?aac?acc 787

Asp?Tyr?Thr?Glu?Tyr?Gly?Ile?Asn?Asp?Ala?Val?Val?Val?Asp?Asn?Thr

215 220 225

ggc?cgc?tgg?cgt?gac?cgc?gaa?ggc?ctg?tcc?cag?cac?ctc?aag?tcc?aag 835

Gly?Arg?Trp?Arg?Asp?Arg?Glu?Gly?Leu?Ser?Gln?His?Leu?Lys?Ser?Lys

230 235 240 245

ggc?gtt?gcc?aag?gtt?gta?ctc?acc?gcg?ccg?ggc?aag?ggc?gat?ctg?aag 883

Gly?Val?Ala?Lys?Val?Val?Leu?Thr?Ala?Pro?Gly?Lys?Gly?Asp?Leu?Lys

250 255 260

aac?atc?gtg?tac?ggc?atc?aac?cac?acc?gac?atc?acc?gca?gat?gat?cag 931

Asn?Ile?Val?Tyr?Gly?Ile?Asn?His?Thr?Asp?Ile?Thr?Ala?Asp?Asp?Gln

265 270 275

atc?gtt?tcc?gca?gca?tca?tgc?acc?acc?aat?gcc?att?acc?cca?gtg?ctc 979

Ile?Val?Ser?Ala?Ala?Ser?Cys?Thr?Thr?Asn?Ala?Ile?Thr?Pro?Val?Leu

280 285 290

aag?gtg?atc?aat?gat?cgc?tac?ggc?gtg?gaa?ttc?ggc?cac?gta?gaa?acc 1027

Lys?Val?Ile?Asn?Asp?Arg?Tyr?Gly?Val?Glu?Phe?Gly?His?Val?Glu?Thr

295 300 305

gtt?cac?tcc?ttc?acc?aat?gac?cag?aac?ctg?atc?gac?aac?ttc?cac?aag 1075

Val?His?Ser?Phe?Thr?Asn?Asp?Gln?Asn?Leu?Ile?Asp?Asn?Phe?His?Lys

310 315 320 325

ggt?tct?cgc?cgt?ggt?cgc?gca?gca?ggt?ctg?aat?atg?gtt?ctc?acc?gaa 1123

Gly?Ser?Arg?Arg?Gly?Arg?Ala?Ala?Gly?Leu?Asn?Met?Val?Leu?Thr?Glu

330 335 340

acc?ggc?gct?gca?aag?gct?gta?tcc?aag?gcg?ctt?cca?gag?ctg?gaa?ggc 1171

Thr?Gly?Ala?Ala?Lys?Ala?Val?Ser?Lys?Ala?Leu?Pro?Glu?Leu?Glu?Gly

345 350 355

aag?ctc?acc?ggc?aat?gcc?atc?cgc?gtt?cct?acc?cct?gac?gtg?tcc?atg 1219

Lys?Leu?Thr?Gly?Asn?Ala?Ile?Arg?Val?Pro?Thr?Pro?Asp?Val?Ser?Met

360 365 370

gct?gtg?ctc?aac?ttg?acc?ctg?aac?acg?gag?gtg?gac?cgc?gat?gag?gtc 1267

Ala?Val?Leu?Asn?Leu?Thr?Leu?Asn?Thr?Glu?Val?Asp?Arg?Asp?Glu?Val

375 380 385

aac?gag?ttc?ctc?cgc?cgt?gtg?tcc?ctg?cac?tct?gac?ttg?cgc?cag?caa 1315

Asn?Glu?Phe?Leu?Arg?Arg?Val?Ser?Leu?His?Ser?Asp?Leu?Arg?Gln?Gln

390 395 400 405

atc?gac?tgg?atc?cgt?tcc?cca?gag?gtt?gtt?tcc?act?gac?ttc?gtg?ggc 1363

Ile?Asp?Trp?Ile?Arg?Ser?Pro?Glu?Val?Val?Ser?Thr?Asp?Phe?Val?Gly

410 415 420

acc?acc?cac?gcg?ggc?atc?gtt?gat?ggt?cta?gcc?acc?atc?gca?acc?ggt 1411

Thr?Thr?His?Ala?Gly?Ile?Val?Asp?Gly?Leu?Ala?Thr?Ile?Ala?Thr?Gly

425 430 435

cgc?cac?ctg?gtg?ctt?tac?gtg?tgg?tac?gac?aac?gag?ttc?ggc?tac?tcc 1459

Arg?His?Leu?Val?Leu?Tyr?Val?Trp?Tyr?Asp?Asn?Glu?Phe?Gly?Tyr?Ser

440 445 450

aac?cag?gtc?att?cgc?atc?gtc?gag?gag?atc?gcc?ggc?gtg?cgt?cct?cgc 1507

Asn?Gln?Val?Ile?Arg?Ile?Val?Glu?Glu?Ile?Ala?Gly?Val?Arg?Pro?Arg

455 460 465

gtg?tac?ccg?gag?cgc?agg?cag?cca?gcc?gta?cta?taggttatcc?aagcctaata?1560

Val?Tyr?Pro?Glu?Arg?Arg?Gln?Pro?Ala?Val?Leu

470 475 480

cac 1563

<210>64

<211>480

<212>PRT

＜213〉Corynebacterium glutamicum

<400>64

Met?Thr?His?Asn?His?Lys?Asp?Trp?Asn?Asp?Arg?Ile?Ala?Val?Ala?Glu

1 5 10 15

Glu?Met?Val?Pro?Leu?Ile?Gly?Arg?Leu?His?Arg?Asn?Asn?Asn?Val?Val

20 25 30

Val?Ser?Val?Phe?Gly?Arg?Leu?Leu?Val?Asn?Val?Ser?Asp?Ile?Asp?Ile

35 40 45

Ile?Lys?Ser?His?Arg?Tyr?Ala?Arg?His?Ile?Ile?Ser?Lys?Glu?Leu?Pro

50 55 60

Leu?Glu?Ser?Ser?Leu?Asp?Ile?Leu?Arg?Glu?Leu?Val?Asp?Met?Asn?Leu

65 70 75 80

Gly?Thr?Ala?Ser?Ile?Asp?Leu?Gly?Gln?Leu?Ala?Tyr?Ser?Phe?Glu?Glu

85 90 95

Ser?Glu?Ser?Thr?Asp?Leu?Arg?Ala?Phe?Leu?Glu?Asp?Ala?Leu?Ala?Pro

100 105 110

Val?Ile?Gly?Ala?Glu?Thr?Asp?Ile?Asn?Pro?Thr?Asp?Ile?Val?Leu?Tyr

115 120 125

Gly?Phe?Gly?Arg?Ile?Gly?Arg?Leu?Leu?Ala?Arg?Ile?Leu?Val?Ser?Arg

130 135 140

Glu?Ala?Leu?Tyr?Asp?Gly?Ala?Arg?Leu?Arg?Ala?Ile?Val?Val?Arg?Lys

145 150 155 160

Asn?Gly?Glu?Glu?Asp?Leu?Val?Lys?Arg?Ala?Ser?Leu?Leu?Arg?Arg?Asp

165 170 175

Ser?Val?His?Gly?Gly?Phe?Asp?Gly?Thr?Ile?Thr?Thr?Asp?Tyr?Asp?Asn

180 185 190

Asn?Ile?Ile?Trp?Ala?Asn?Gly?Thr?Pro?Ile?Lys?Val?Ile?Tyr?Ser?Asn

195 200 205

Asp?Pro?Ala?Thr?Ile?Asp?Tyr?Thr?Glu?Tyr?Gly?Ile?Asn?Asp?Ala?Val

210 215 220

Val?Val?Asp?Asn?Thr?Gly?Arg?Trp?Arg?Asp?Arg?Glu?Gly?Leu?Ser?Gln

225 230 235 240

His?Leu?Lys?Ser?Lys?Gly?Val?Ala?Lys?Val?Val?Leu?Thr?Ala?Pro?Gly

245 250 255

Lys?Gly?Asp?Leu?Lys?Asn?Ile?Val?Tyr?Gly?Ile?Asn?His?Thr?Asp?Ile

260 265 270

Thr?Ala?Asp?Asp?Gln?Ile?Val?Ser?Ala?Ala?Ser?Cys?Thr?Thr?Asn?Ala

275 280 285

Ile?Thr?Pro?Val?Leu?Lys?Val?Ile?Asn?Asp?Arg?Tyr?Gly?Val?Glu?Phe

290 295 300

Gly?His?Val?Glu?Thr?Val?His?Ser?Phe?Thr?Asn?Asp?Gln?Asn?Leu?Ile

305 310 315 320

Asp?Asn?Phe?His?Lys?Gly?Ser?Arg?Arg?Gly?Arg?Ala?Ala?Gly?Leu?Asn

325 330 335

Met?Val?Leu?Thr?Glu?Thr?Gly?Ala?Ala?Lys?Ala?Val?Ser?Lys?Ala?Leu

340 345 350

Pro?Glu?Leu?Glu?Gly?Lys?Leu?Thr?Gly?Asn?Ala?Ile?Arg?Val?Pro?Thr

355 360 365

Pro?Asp?Val?Ser?Met?Ala?Val?Leu?Asn?Leu?Thr?Leu?Asn?Thr?Glu?Val

370 375 380

Asp?Arg?Asp?Glu?Val?Asn?Glu?Phe?Leu?Arg?Arg?Val?Ser?Leu?His?Ser

385 390 395 400

Asp?Leu?Arg?Gln?Gln?Ile?Asp?Trp?Ile?Arg?Ser?Pro?Glu?Val?Val?Ser

405 410 415

Thr?Asp?Phe?Val?Gly?Thr?Thr?His?Ala?Gly?Ile?Val?Asp?Gly?Leu?Ala

420 425 430

Thr?Ile?Ala?Thr?Gly?Arg?His?Leu?Val?Leu?Tyr?Val?Trp?Tyr?Asp?Asn

435 440 445

Glu?Phe?Gly?Tyr?Ser?Asn?Gln?Val?Ile?Arg?Ile?Val?Glu?Glu?Ile?Ala

450 455 460

Gly?Val?Arg?Pro?Arg?Val?Tyr?Pro?Glu?Arg?Arg?Gln?Pro?Ala?Val?Leu

465 470 475 480

<210>65

<211>1563

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1540)

<223>FRXA01225

<400>65

tttgggctaa?tgttgggggg?agtgctttca?actatccacg?agagctgccc?agtgataaac?60

cccgggttaa?ccccacgcct?aagtcagtga?aggacttttt?atg?acg?cac?aac?cac 115

Met?Thr?His?Asn?His

1 5

aag?gac?tgg?aac?gat?cgc?att?gca?gtt?gcg?gag?gaa?atg?gtg?ccg?ttg 163

Lys?Asp?Trp?Asn?Asp?Arg?Ile?Ala?Val?Ala?Glu?Glu?Met?Val?Pro?Leu

10 15 20

atc?ggg?cgc?ctg?cac?cgc?aac?aac?aac?gtg?gtg?gtt?tcc?gta?ttc?ggt 211

Ile?Gly?Arg?Leu?His?Arg?Asn?Asn?Asn?Val?Val?Val?Ser?Val?Phe?Gly

25 30 35

cgt?ctc?ctt?gtg?aat?gtc?tca?gac?atc?gat?atc?atc?aag?tct?cac?cgc 259

Arg?Leu?Leu?Val?Asn?Val?Ser?Asp?Ile?Asp?Ile?Ile?Lys?Ser?His?Arg

40 45 50

tac?gcc?cgc?cac?atc?ata?tcc?aag?gaa?ctt?cca?ctg?gaa?agc?tcc?ttg 307

Tyr?Ala?Arg?His?Ile?Ile?Ser?Lys?Glu?Leu?Pro?Leu?Glu?Ser?Ser?Leu

55 60 65

gat?att?ttg?cgc?gaa?ctg?gta?gat?atg?aac?ctt?ggt?acc?gca?tcg?atc 355

Asp?Ile?Leu?Arg?Glu?Leu?Val?Asp?Met?Asn?Leu?Gly?Thr?Ala?Ser?Ile

70 75 80 85

gac?ctg?gga?cag?ctg?gcc?tac?agc?ttc?gaa?gaa?tcc?gaa?agc?acc?gac 403

Asp?Leu?Gly?Gln?Leu?Ala?Tyr?Ser?Phe?Glu?Glu?Ser?Glu?Ser?Thr?Asp

90 95 100

ctg?cgt?gcc?ttc?ctg?gag?gac?gct?ctc?gcg?ccg?gtc?att?ggt?gcg?gaa 451

Leu?Arg?Ala?Phe?Leu?Glu?Asp?Ala?Leu?Ala?Pro?Val?Ile?Gly?Ala?Glu

105 110 115

acc?gac?atc?aac?cca?act?gat?atc?gtg?ctg?tac?ggt?ttc?ggc?cgc?atc 499

Thr?Asp?Ile?Asn?Pro?Thr?Asp?Ile?Val?Leu?Tyr?Gly?Phe?Gly?Arg?Ile

120 125 130

ggt?cgc?ctg?ctg?gcc?cgc?atc?ctg?gtt?tcc?cgc?gag?gca?ctg?tat?gac 547

Gly?Arg?Leu?Leu?Ala?Arg?Ile?Leu?Val?Ser?Arg?Glu?Ala?Leu?Tyr?Asp

135 140 145

ggt?gct?cgt?ctg?cgc?gcc?atc?gtg?gtc?cgc?aaa?aat?ggt?gaa?gaa?gac 595

Gly?Ala?Arg?Leu?Arg?Ala?Ile?Val?Val?Arg?Lys?Asn?Gly?Glu?Glu?Asp

150 155 160 165

ctg?gtc?aag?cgc?gca?tcc?ttg?ctg?cgt?cgt?gat?tct?gtc?cac?ggt?gga 643

Leu?Val?Lys?Arg?Ala?Ser?Leu?Leu?Arg?Arg?Asp?Ser?Val?His?Gly?Gly

170 175 180

ttc?gat?ggc?acc?atc?acc?acc?gat?tat?gac?aac?aac?atc?atc?tgg?gcc 691

Phe?Asp?Gly?Thr?Ile?Thr?Thr?Asp?Tyr?Asp?Asn?Asn?Ile?Ile?Trp?Ala

185 190 195

aac?ggc?acc?cca?atc?aag?gtc?atc?tac?tcc?aat?gac?cca?gcc?acc?att 739

Asn?Gly?Thr?Pro?Ile?Lys?Val?Ile?Tyr?Ser?Asn?Asp?Pro?Ala?Thr?Ile

200 205 210

gat?tac?acc?gaa?tac?ggc?atc?aat?gac?gcc?gtc?gtg?gta?gac?aac?acc 787

Asp?Tyr?Thr?Glu?Tyr?Gly?Ile?Asn?Asp?Ala?Val?Val?Val?Asp?Asn?Thr

215 220 225

ggc?cgc?tgg?cgt?gac?cgc?gaa?ggc?ctg?tcc?cag?cac?ctc?aag?tcc?aag 835

Gly?Arg?Trp?Arg?Asp?Arg?Glu?Gly?Leu?Ser?Gln?His?Leu?Lys?Ser?Lys

230 235 240 245

ggc?gtt?gcc?aag?gtt?gta?ctc?acc?gcg?ccg?ggc?aag?ggc?gat?ctg?aag 883

Gly?Val?Ala?Lys?Val?Val?Leu?Thr?Ala?Pro?Gly?Lys?Gly?Asp?Leu?Lys

250 255 260

aac?atc?gtg?tac?ggc?atc?aac?cac?acc?gac?atc?acc?gca?gat?gat?cag 931

Asn?Ile?Val?Tyr?Gly?Ile?Asn?His?Thr?Asp?Ile?Thr?Ala?Asp?Asp?Gln

265 270 275

atc?gtt?tcc?gca?gca?tca?tgc?acc?acc?aat?gcc?att?acc?cca?gtg?ctc 979

Ile?Val?Ser?Ala?Ala?Ser?Cys?Thr?Thr?Asn?Ala?Ile?Thr?Pro?Val?Leu

280 285 290

aag?gtg?atc?aat?gat?cgc?tac?ggc?gtg?gaa?ttc?ggc?cac?gta?gaa?acc 1027

Lys?Val?Ile?Asn?Asp?Arg?Tyr?Gly?Val?Glu?Phe?Gly?His?Val?Glu?Thr

295 300 305

gtt?cac?tcc?ttc?acc?aat?gac?cag?aac?ctg?atc?gac?aac?ttc?cac?aag 1075

Val?His?Ser?Phe?Thr?Asn?Asp?Gln?Asn?Leu?Ile?Asp?Asn?Phe?His?Lys

310 315 320 325

ggt?tct?cgc?cgt?ggt?cgc?gca?gca?ggt?ctg?aat?atg?gtt?ctc?acc?gaa 1123

Gly?Ser?Arg?Arg?Gly?Arg?Ala?Ala?Gly?Leu?Asn?Met?Val?Leu?Thr?Glu

330 335 340

acc?ggc?gct?gca?aag?gct?gta?tcc?aag?gcg?ctt?cca?gag?ctg?gaa?ggc 1171

Thr?Gly?Ala?Ala?Lys?Ala?Val?Ser?Lys?Ala?Leu?Pro?Glu?Leu?Glu?Gly

345 350 355

aag?ctc?acc?ggc?aat?gcc?atc?cgc?gtt?cct?acc?cct?gac?gtg?tcc?atg 1219

Lys?Leu?Thr?Gly?Asn?Ala?Ile?Arg?Val?Pro?Thr?Pro?Asp?Val?Ser?Met

360 365 370

gct?gtg?ctc?aac?ttg?acc?ctg?aac?acg?gag?gtg?gac?cgc?gat?gag?gtc 1267

Ala?Val?Leu?Asn?Leu?Thr?Leu?Asn?Thr?Glu?Val?Asp?Arg?Asp?Glu?Val

375 380 385

aac?gag?ttc?ctc?cgc?cgt?gtg?tcc?ctg?cac?tct?gac?ttg?cgc?cag?caa 1315

Asn?Glu?Phe?Leu?Arg?Arg?Val?Ser?Leu?His?Ser?Asp?Leu?Arg?Gln?Gln

390 395 400 405

atc?gac?tgg?atc?cgt?tcc?cca?gag?gtt?gtt?tcc?act?gac?ttc?gtg?ggc 1363

Ile?Asp?Trp?Ile?Arg?Ser?Pro?Glu?Val?Val?Ser?Thr?Asp?Phe?Val?Gly

410 415 420

acc?acc?cac?gcg?ggc?atc?gtt?gat?ggt?cta?gcc?acc?atc?gca?acc?ggt 1411

Thr?Thr?His?Ala?Gly?Ile?Val?Asp?Gly?Leu?Ala?Thr?Ile?Ala?Thr?Gly

425 430 435

cgc?cac?ctg?gtg?ctt?tac?gtg?tgg?tac?gac?aac?gag?ttc?ggc?tac?tcc 1459

Arg?His?Leu?Val?Leu?Tyr?Val?Trp?Tyr?Asp?Asn?Glu?Phe?Gly?Tyr?Ser

440 445 450

aac?cag?gtc?att?cgc?atc?gtc?gag?gag?atc?gcc?ggc?gtg?cgt?cct?cgc 1507

Asn?Gln?Val?Ile?Arg?Ile?Val?Glu?Glu?Ile?Ala?Gly?Val?Arg?Pro?Arg

455 460 465

gtg?tac?ccg?gag?cgc?agg?cag?cca?gcc?gta?cta?taggttatcc?aagcctaata?1560

Val?Tyr?Pro?Glu?Arg?Arg?Gln?Pro?Ala?Val?Leu

470 475 480

cac 1563

<210>66

<211>480

<212>PRT

＜213〉Corynebacterium glutamicum

<400>66

Met?Thr?His?Asn?His?Lys?Asp?Trp?Asn?Asp?Arg?Ile?Ala?Val?Ala?Glu

1 5 10 15

Glu?Met?Val?Pro?Leu?Ile?Gly?Arg?Leu?His?Arg?Asn?Asn?Asn?Val?Val

20 25 30

Val?Ser?Val?Phe?Gly?Arg?Leu?Leu?Val?Asn?Val?Ser?Asp?Ile?Asp?Ile

35 40 45

Ile?Lys?Ser?His?Arg?Tyr?Ala?Arg?His?Ile?Ile?Ser?Lys?Glu?Leu?Pro

50 55 60

Leu?Glu?Ser?Ser?Leu?Asp?Ile?Leu?Arg?Glu?Leu?Val?Asp?Met?Asn?Leu

65 70 75 80

Gly?Thr?Ala?Ser?Ile?Asp?Leu?Gly?Gln?Leu?Ala?Tyr?Ser?Phe?Glu?Glu

85 90 95

Ser?Glu?Ser?Thr?Asp?Leu?Arg?Ala?Phe?Leu?Glu?Asp?Ala?Leu?Ala?Pro

100 105 110

Val?Ile?Gly?Ala?Glu?Thr?Asp?Ile?Asn?Pro?Thr?Asp?Ile?Val?Leu?Tyr

115 120 125

Gly?Phe?Gly?Arg?Ile?Gly?Arg?Leu?Leu?Ala?Arg?Ile?Leu?Val?Ser?Arg

130 135 140

Glu?Ala?Leu?Tyr?Asp?Gly?Ala?Arg?Leu?Arg?Ala?Ile?Val?Val?Arg?Lys

145 150 155 160

Asn?Gly?Glu?Glu?Asp?Leu?Val?Lys?Arg?Ala?Ser?Leu?Leu?Arg?Arg?Asp

165 170 175

Ser?Val?His?Gly?Gly?Phe?Asp?Gly?Thr?Ile?Thr?Thr?Asp?Tyr?Asp?Asn

180 185 190

Asn?Ile?Ile?Trp?Ala?Asn?Gly?Thr?Pro?Ile?Lys?Val?Ile?Tyr?Ser?Asn

195 200 205

Asp?Pro?Ala?Thr?Ile?Asp?Tyr?Thr?Glu?Tyr?Gly?Ile?Asn?Asp?Ala?Val

210 215 220

Val?Val?Asp?Asn?Thr?Gly?Arg?Trp?Arg?Asp?Arg?Glu?Gly?Leu?Ser?Gln

225 230 235 240

His?Leu?Lys?Ser?Lys?Gly?Val?Ala?Lys?Val?Val?Leu?Thr?Ala?Pro?Gly

245 250 255

Lys?Gly?Asp?Leu?Lys?Asn?Ile?Val?Tyr?Gly?Ile?Asn?His?Thr?Asp?Ile

260 265 270

Thr?Ala?Asp?Asp?Gln?Ile?Val?Ser?Ala?Ala?Ser?Cys?Thr?Thr?Asn?Ala

275 280 285

Ile?Thr?Pro?Val?Leu?Lys?Val?Ile?Asn?Asp?Arg?Tyr?Gly?Val?Glu?Phe

290 295 300

Gly?His?Val?Glu?Thr?Val?His?Ser?Phe?Thr?Asn?Asp?Gln?Asn?Leu?Ile

305 310 315 320

Asp?Asn?Phe?His?Lys?Gly?Ser?Arg?Arg?Gly?Arg?Ala?Ala?Gly?Leu?Asn

325 330 335

Met?Val?Leu?Thr?Glu?Thr?Gly?Ala?Ala?Lys?Ala?Val?Ser?Lys?Ala?Leu

340 345 350

Pro?Glu?Leu?Glu?Gly?Lys?Leu?Thr?Gly?Asn?Ala?Ile?Arg?Val?Pro?Thr

355 360 365

Pro?Asp?Val?Ser?Met?Ala?Val?Leu?Asn?Leu?Thr?Leu?Asn?Thr?Glu?Val

370 375 380

Asp?Arg?Asp?Glu?Val?Asn?Glu?Phe?Leu?Arg?Arg?Val?Ser?Leu?His?Ser

385 390 395 400

Asp?Leu?Arg?Gln?Gln?Ile?Asp?Trp?Ile?Arg?Ser?Pro?Glu?Val?Val?Ser

405 410 415

Thr?Asp?Phe?Val?Gly?Thr?Thr?His?Ala?Gly?Ile?Val?Asp?Gly?Leu?Ala

420 425 430

Thr?Ile?Ala?Thr?Gly?Arg?His?Leu?Val?Leu?Tyr?Val?Trp?Tyr?Asp?Asn

435 440 445

Glu?Phe?Gly?Tyr?Ser?Asn?Gln?Val?Ile?Arg?Ile?Val?Glu?Glu?Ile?Ala

450 455 460

Gly?Val?Arg?Pro?Arg?Val?Tyr?Pro?Glu?Arg?Arg?Gln?Pro?Ala?Val?Leu

465 470 475 480

<210>67

<211>1125

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1102)

<223>RXA02256

<400>67

ttgggttctg?tcagctcaag?aattcttgag?tgaccgatgc?tctgattgac?ctaactgctt?60

gacacattgc?atttcctaca?atctttagag?gagacacaac?atg?acc?att?cgt?gtt 115

Met?Thr?Ile?Arg?Val

1 5

ggt?att?aac?gga?ttt?ggc?cgt?atc?gga?cgt?aac?ttc?ttc?cgc?gca?gtt 163

Gly?Ile?Asn?Gly?Phe?Gly?Arg?Ile?Gly?Arg?Asn?Phe?Phe?Arg?Ala?Val

10 15 20

ctg?gag?cgc?agc?gac?gat?ctc?gag?gta?gtt?gca?gtc?aac?gac?ctc?acc 211

Leu?Glu?Arg?Ser?Asp?Asp?Leu?Glu?Val?Val?Ala?Val?Asn?Asp?Leu?Thr

25 30 35

gac?aac?aag?acc?ctt?tcc?acc?ctt?ctc?aag?ttc?gac?tcc?atc?atg?ggc 259

Asp?Asn?Lys?Thr?Leu?Ser?Thr?Leu?Leu?Lys?Phe?Asp?Ser?Ile?Met?Gly

40 45 50

cgc?ctt?ggc?cag?gaa?gtt?gaa?tac?gac?gat?gac?tcc?atc?acc?gtt?ggt 307

Arg?Leu?Gly?Gln?Glu?Val?Glu?Tyr?Asp?Asp?Asp?Ser?Ile?Thr?Val?Gly

55 60 65

ggc?aag?cgc?atc?gct?gtt?tac?gca?gag?cgc?gat?cca?aag?aac?ctg?gac 355

Gly?Lys?Arg?Ile?Ala?Val?Tyr?Ala?Glu?Arg?Asp?Pro?Lys?Asn?Leu?Asp

70 75 80 85

tgg?gct?gca?cac?aac?gtt?gac?atc?gtg?atc?gag?tcc?acc?ggc?ttc?ttc 403

Trp?Ala?Ala?His?Asn?Val?Asp?Ile?Val?Ile?Glu?Ser?Thr?Gly?Phe?Phe

90 95 100

acc?gat?gca?aac?gcg?gct?aag?gct?cac?atc?gaa?gca?ggt?gcc?aag?aag 451

Thr?Asp?Ala?Asn?Ala?Ala?Lys?Ala?His?Ile?Glu?Ala?Gly?Ala?Lys?Lys

105 110 115

gtc?atc?atc?tcc?gca?cca?gca?agc?aac?gaa?gac?gca?acc?ttc?gtt?tac 499

Val?Ile?Ile?Ser?Ala?Pro?Ala?Ser?Asn?Glu?Asp?Ala?Thr?Phe?Val?Tyr

120 125 130

ggt?gtg?aac?cac?gag?tcc?tac?gat?cct?gag?aac?cac?aac?gtg?atc?tcc 547

Gly?Val?Asn?His?Glu?Ser?Tyr?Asp?Pro?Glu?Asn?His?Asn?Val?Ile?Ser

135 140 145

ggc?gca?tct?tgc?acc?acc?aac?tgc?ctc?gca?cca?atg?gca?aag?gtc?cta 595

Gly?Ala?Ser?Cys?Thr?Thr?Asn?Cys?Leu?Ala?Pro?Met?Ala?Lys?Val?Leu

150 155 160 165

aac?gac?aag?ttc?ggc?atc?gag?aac?ggc?ctc?atg?acc?acc?gtt?cac?gca 643

Asn?Asp?Lys?Phe?Gly?Ile?Glu?Asn?Gly?Leu?Met?Thr?Thr?Val?His?Ala

170 175 180

tac?act?ggc?gac?cag?cgc?ctg?cac?gat?gca?cct?cac?cgc?gac?ctg?cgt 691

Tyr?Thr?Gly?Asp?Gln?Arg?Leu?His?Asp?Ala?Pro?His?Arg?Asp?Leu?Arg

185 190 195

cgt?gca?cgt?gca?gca?gca?gtc?aac?atc?gtt?cct?acc?tcc?acc?ggt?gca 739

Arg?Ala?Arg?Ala?Ala?Ala?Val?Asn?Ile?Val?Pro?Thr?Ser?Thr?Gly?Ala

200 205 210

gct?aag?gct?gtt?gct?ctg?gtt?ctc?cca?gag?ctc?aag?ggc?aag?ctt?gac 787

Ala?Lys?Ala?Val?Ala?Leu?Val?Leu?Pro?Glu?Leu?Lys?Gly?Lys?Leu?Asp

215 220 225

ggc?tac?gca?ctt?cgc?gtt?cca?gtt?atc?acc?ggt?tcc?gca?acc?gac?ctg 835

Gly?Tyr?Ala?Leu?Arg?Val?Pro?Val?Ile?Thr?Gly?Ser?Ala?Thr?Asp?Leu

230 235 240 245

acc?ttc?aac?acc?aag?tct?gag?gtc?acc?gtt?gag?tcc?atc?aac?gct?gca 883

Thr?Phe?Asn?Thr?Lys?Ser?Glu?Val?Thr?Val?Glu?Ser?Ile?Asn?Ala?Ala

250 255 260

atc?aag?gaa?gct?gca?gtc?ggc?gag?ttc?ggc?gag?acc?ctg?gct?tac?tcc 931

Ile?Lys?Glu?Ala?Ala?Val?Gly?Glu?Phe?Gly?Glu?Thr?Leu?Ala?Tyr?Ser

265 270 275

gaa?gag?cca?ctg?gtt?tcc?acc?gac?atc?gtc?cac?gat?tcc?cac?ggc?tcc 979

Glu?Glu?Pro?Leu?Val?Ser?Thr?Asp?Ile?Val?His?Asp?Ser?His?Gly?Ser

280 285 290

atc?ttc?gac?gct?ggc?ctg?acc?aag?gtc?tcc?ggc?aac?acc?gtc?aag?gtt 1027

Ile?Phe?Asp?Ala?Gly?Leu?Thr?Lys?Val?Ser?Gly?Asn?Thr?Val?Lys?Val

295 300 305

gtt?tcc?tgg?tac?gac?aac?gag?tgg?ggc?tac?acc?tgc?cag?ctc?ctg?cgt 1075

Val?Ser?Trp?Tyr?Asp?Asn?Glu?Trp?Gly?Tyr?Thr?Cys?Gln?Leu?Leu?Arg

310 315 320 325

ctg?acc?gag?ctc?gta?gct?tcc?aag?ctc?taattagttc?acatcgctaa 1122

Leu?Thr?Glu?Leu?Val?Ala?Ser?Lys?Leu

330

cgt 1125

<210>68

<211>334

<212>PRT

＜213〉Corynebacterium glutamicum

<400>68

Met?Thr?Ile?Arg?Val?Gly?Ile?Asn?Gly?Phe?Gly?Arg?Ile?Gly?Arg?Asn

1 5 10 15

Phe?Phe?Arg?Ala?Val?Leu?Glu?Arg?Ser?Asp?Asp?Leu?Glu?Val?Val?Ala

20 25 30

Val?Asn?Asp?Leu?Thr?Asp?Asn?Lys?Thr?Leu?Ser?Thr?Leu?Leu?Lys?Phe

35 40 45

Asp?Ser?Ile?Met?Gly?Arg?Leu?Gly?Gln?Glu?Val?Glu?Tyr?Asp?Asp?Asp

50 55 60

Ser?Ile?Thr?Val?Gly?Gly?Lys?Arg?Ile?Ala?Val?Tyr?Ala?Glu?Arg?Asp

65 70 75 80

Pro?Lys?Asn?Leu?Asp?Trp?Ala?Ala?His?Asn?Val?Asp?Ile?Val?Ile?Glu

85 90 95

Ser?Thr?Gly?Phe?Phe?Thr?Asp?Ala?Asn?Ala?Ala?Lys?Ala?His?Ile?Glu

100 105 110

Ala?Gly?Ala?Lys?Lys?Val?Ile?Ile?Ser?Ala?Pro?Ala?Ser?Asn?Glu?Asp

115 120 125

Ala?Thr?Phe?Val?Tyr?Gly?Val?Asn?His?Glu?Ser?Tyr?Asp?Pro?Glu?Asn

130 135 140

His?Asn?Val?Ile?Ser?Gly?Ala?Ser?Cys?Thr?Thr?Asn?Cys?Leu?Ala?Pro

145 150 155 160

Met?Ala?Lys?Val?Leu?Asn?Asp?Lys?Phe?Gly?Ile?Glu?Asn?Gly?Leu?Met

165 170 175

Thr?Thr?Val?His?Ala?Tyr?Thr?Gly?Asp?Gln?Arg?Leu?His?Asp?Ala?Pro

180 185 190

His?Arg?Asp?Leu?Arg?Arg?Ala?Arg?Ala?Ala?Ala?Val?Asn?Ile?Val?Pro

195 200 205

Thr?Ser?Thr?Gly?Ala?Ala?Lys?Ala?Val?Ala?Leu?Val?Leu?Pro?Glu?Leu

210 215 220

Lys?Gly?Lys?Leu?Asp?Gly?Tyr?Ala?Leu?Arg?Val?Pro?Val?Ile?Thr?Gly

225 230 235 240

Ser?Ala?Thr?Asp?Leu?Thr?Phe?Asn?Thr?Lys?Ser?Glu?Val?Thr?Val?Glu

245 250 255

Ser?Ile?Asn?Ala?Ala?Ile?Lys?Glu?Ala?Ala?Val?Gly?Glu?Phe?Gly?Glu

260 265 270

Thr?Leu?Ala?Tyr?Ser?Glu?Glu?Pro?Leu?Val?Ser?Thr?Asp?Ile?Val?His

275 280 285

Asp?Ser?His?Gly?Ser?Ile?Phe?Asp?Ala?Gly?Leu?Thr?Lys?Val?Ser?Gly

290 295 300

Asn?Thr?Val?Lys?Val?Val?Ser?Trp?Tyr?Asp?Asn?Glu?Trp?Gly?Tyr?Thr

305 310 315 320

Cys?Gln?Leu?Leu?Arg?Leu?Thr?Glu?Leu?Val?Ala?Ser?Lys?Leu

325 330

<210>69

<211>1338

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1315)

<223>RXA02257

<400>69

ataccggtgc?cagcgccaca?caatgtgtgg?caatctggga?cagtgcatca?cattgcacca?60

gaagaatttt?ttaaacaatc?aaatctccaa?ggagtacggc?atg?gct?gtt?aag?acc 115

Met?Ala?Val?Lys?Thr

1 5

ctc?aag?gac?ttg?ctc?gac?gaa?ggc?gta?gac?gga?cgc?cac?gtc?atc?gtt 163

Leu?Lys?Asp?Leu?Leu?Asp?Glu?Gly?Val?Asp?Gly?Arg?His?Val?Ile?Val

10 15 20

cga?tct?gac?ttc?aat?gtt?ccc?ctc?aac?gat?gac?cgc?gag?atc?acc?gat 211

Arg?Ser?Asp?Phe?Asn?Val?Pro?Leu?Asn?Asp?Asp?Arg?Glu?IleThr?Asp

25 30 35

aag?ggc?cga?atc?att?gcc?tcc?cta?cca?acc?ctt?aaa?gca?ctg?agc?gaa 259

Lys?Gly?Arg?Ile?Ile?Ala?Ser?Leu?Pro?Thr?Leu?Lys?Ala?Leu?Ser?Glu

40 45 50

ggt?ggc?gca?aag?gtc?atc?gtc?atg?gct?cac?ctt?ggc?cgc?cca?aag?ggc 307

Gly?Gly?Ala?Lys?Val?Ile?Val?Met?Ala?His?Leu?Gly?Arg?Pro?Lys?Gly

55 60 65

gag?gtc?aac?gag?aag?tac?tcc?ctc?gca?cct?gtc?gct?gag?gca?ctc?tcc 355

Glu?Val?Asn?Glu?Lys?Tyr?Ser?Leu?Ala?Pro?Val?Ala?Glu?Ala?Leu?Ser

70 75 80 85

gat?gag?ctt?ggc?cag?tac?gtt?gca?ctt?gcc?gca?gac?gtt?gtt?ggc?gaa 403

Asp?Glu?Leu?Gly?Gln?Tyr?Val?Ala?Leu?Ala?Ala?Asp?Val?Val?Gly?Glu

90 95 100

gac?gca?cac?gag?cgc?gca?aac?ggc?ctg?acc?gag?ggc?gac?atc?ctg?ctc 451

Asp?Ala?His?Glu?Arg?Ala?Asn?Gly?Leu?Thr?Glu?Gly?Asp?Ile?Leu?Leu

105 110 115

ctg?gag?aac?gtg?cgc?ttc?gac?cca?cgc?gaa?acc?tcc?aag?gac?gag?gca 499

Leu?Glu?Asn?Val?Arg?Phe?Asp?Pro?Arg?Glu?Thr?Ser?Lys?Asp?Glu?Ala

120 125 130

gag?cgc?acc?gct?ttc?gct?cag?gag?ctc?gca?gct?ctt?gca?gca?gac?aac 547

Glu?Arg?Thr?Ala?Phe?Ala?Gln?Glu?Leu?Ala?Ala?Leu?Ala?Ala?Asp?Asn

135 140 145

ggc?gca?ttc?gtt?tct?gac?ggc?ttc?ggt?gtt?gtc?cac?cgc?gca?cag?acc 595

Gly?Ala?Phe?Val?Ser?Asp?Gly?Phe?Gly?Val?Val?His?Arg?Ala?Gln?Thr

150 155 160 165

tcc?gtc?tac?gac?att?gca?aag?ttg?ctg?cca?cac?tac?gct?ggc?gga?ctg 643

Ser?Val?Tyr?Asp?Ile?Ala?Lys?Leu?Leu?Pro?His?Tyr?Ala?Gly?Gly?Leu

170 175 180

gta?gag?acc?gag?att?tcc?gtt?ctg?gaa?aag?atc?gca?gaa?tca?cca?gag 691

Val?Glu?Thr?Glu?Ile?Ser?Val?Leu?Glu?Lys?Ile?Ala?Glu?Ser?Pro?Glu

185 190 195

gca?cca?tac?gta?gtg?gtt?ctc?ggt?gga?tcc?aag?gtc?tct?gac?aag?atc 739

Ala?Pro?Tyr?Val?Val?Val?Leu?Gly?Gly?Ser?Lys?Val?Ser?Asp?Lys?Ile

200 205 210

ggt?gtt?att?gag?gcg?ctg?gct?gcc?aag?gct?gac?aag?atc?atc?gtc?ggt 787

Gly?Val?Ile?Glu?Ala?Leu?Ala?Ala?Lys?Ala?Asp?Lys?Ile?Ile?Val?Gly

215 220 225

ggc?ggc?atg?tgc?tac?acc?ttc?ctc?gca?gct?cag?gga?cac?aac?gtt?cag 835

Gly?Gly?Met?Cys?Tyr?Thr?Phe?Leu?Ala?Ala?Gln?Gly?His?Asn?Val?Gln

230 235 240 245

cag?tcc?ctc?ctg?cag?gaa?gaa?atg?aag?gct?acc?tgc?acc?gac?ctg?ctc 883

Gln?Ser?Leu?Leu?Gln?Glu?Glu?Met?Lys?Ala?Thr?Cys?Thr?Asp?Leu?Leu

250 255 260

gca?cgc?ttc?ggt?gac?aag?atc?gtt?ctc?cca?gtt?gac?ctg?gtt?gca?gca 931

Ala?Arg?Phe?Gly?Asp?Lys?Ile?Val?Leu?Pro?Val?Asp?Leu?Val?Ala?Ala

265 270 275

tcc?gaa?ttt?aac?aag?gac?gca?gag?aag?cag?atc?gtt?gac?ctg?gac?tcc 979

Ser?Glu?Phe?Asn?Lys?Asp?Ala?Glu?Lys?Gln?Ile?Val?Asp?Leu?Asp?Ser

280 285 290

atc?cca?gaa?ggc?tgg?atg?tct?ctt?gac?atc?gga?cca?gag?tcc?gtc?aag 1027

Ile?Pro?Glu?Gly?Trp?Met?Ser?Leu?Asp?Ile?Gly?Pro?Glu?Ser?Val?Lys

295 300 305

aac?ttc?ggt?gag?gtt?ctc?agc?acc?gct?aag?acc?atc?ttc?tgg?aac?ggc 1075

Asn?Phe?Gly?Glu?Val?Leu?Ser?Thr?Ala?Lys?Thr?Ile?Phe?Trp?Asn?Gly

310 315 320 325

cca?atg?ggc?gtg?ttc?gag?ttc?gca?gca?ttc?tct?gaa?ggc?acc?cgc?ggc 1123

Pro?Met?Gly?Val?Phe?Glu?Phe?Ala?Ala?Phe?Ser?Glu?Gly?Thr?Arg?Gly

330 335 340

atc?gcc?cag?gcc?atc?atc?gat?gca?act?gca?ggc?aac?gac?gca?ttc?tcc 1171

Ile?Ala?Gln?Ala?Ile?Ile?Asp?Ala?Thr?Ala?Gly?Asn?Asp?Ala?Phe?Ser

345 350 355

gtt?gtt?ggc?ggt?ggc?gac?tcc?gca?gca?tcc?gtt?cgc?gtg?ctc?ggc?ctg 1219

Val?Val?Gly?Gly?Gly?Asp?Ser?Ala?Ala?Ser?Val?Arg?Val?Leu?Gly?Leu

360 365 370

aac?gaa?gac?ggc?ttc?tcc?cac?atc?tcc?acc?ggt?ggt?ggc?gca?tcc?ctc 1267

Asn?Glu?Asp?Gly?Phe?Ser?His?Ile?Ser?Thr?Gly?Gly?Gly?Ala?Ser?Leu

375 380 385

gag?tac?ctt?gaa?ggc?aag?gaa?ctc?cca?ggc?gtt?gca?att?ctc?gct?cag 1315

Glu?Tyr?Leu?Glu?Gly?Lys?Glu?Leu?Pro?Gly?Val?Ala?Ile?Leu?Ala?Gln

390 395 400 405

taaatccgac?acggcccttt?gtt 1338

<210>70

<211>405

<212>PRT

＜213〉Corynebacterium glutamicum

<400>70

Met?Ala?Val?Lys?Thr?Leu?Lys?Asp?Leu?Leu?Asp?Glu?Gly?Val?Asp?Gly

1 5 10 15

Arg?His?Val?Ile?Val?Arg?Ser?Asp?Phe?Asn?Val?Pro?Leu?Asn?Asp?Asp

20 25 30

Arg?Glu?Ile?Thr?Asp?Lys?Gly?Arg?Ile?Ile?Ala?Ser?Leu?Pro?Thr?Leu

35 40 45

Lys?Ala?Leu?Ser?Glu?Gly?Gly?Ala?Lys?Val?Ile?Val?Met?Ala?His?Leu

50 55 60

Gly?Arg?Pro?Lys?Gly?Glu?Val?Asn?Glu?Lys?Tyr?Ser?Leu?Ala?Pro?Val

65 70 75 80

Ala?Glu?Ala?Leu?Ser?Asp?Glu?Leu?Gly?Gln?Tyr?Val?Ala?Leu?Ala?Ala

85 90 95

Asp?Val?Val?Gly?Glu?Asp?Ala?His?Glu?Arg?Ala?Asn?Gly?Leu?Thr?Glu

100 105 110

Gly?Asp?Ile?Leu?Leu?Leu?Glu?Asn?Val?Arg?Phe?Asp?Pro?Arg?Glu?Thr

115 120 125

Ser?Lys?Asp?Glu?Ala?Glu?Arg?Thr?Ala?Phe?Ala?Gln?Glu?Leu?Ala?Ala

130 135 140

Leu?Ala?Ala?Asp?Asn?Gly?Ala?Phe?Val?Ser?Asp?Gly?Phe?Gly?Val?Val

145 150 155 160

His?Arg?Ala?Gln?Thr?Ser?Val?Tyr?Asp?Ile?Ala?Lys?Leu?Leu?Pro?His

165 170 175

Tyr?Ala?Gly?Gly?Leu?Val?Glu?Thr?Glu?Ile?Ser?Val?Leu?Glu?Lys?Ile

180 185 190

Ala?Glu?Ser?Pro?Glu?Ala?Pro?Tyr?Val?Val?Val?Leu?Gly?Gly?Ser?Lys

195 200 205

Val?Ser?Asp?Lys?Ile?Gly?Val?Ile?Glu?Ala?Leu?Ala?Ala?Lys?Ala?Asp

210 215 220

Lys?Ile?Ile?Val?Gly?Gly?Gly?Met?Cys?Tyr?Thr?Phe?Leu?Ala?Ala?Gln

225 230 235 240

Gly?His?Asn?Val?Gln?Gln?Ser?Leu?Leu?Gln?Glu?Glu?Met?Lys?Ala?Thr

245 250 255

Cys?Thr?Asp?Leu?Leu?Ala?Arg?Phe?Gly?Asp?Lys?Ile?Val?Leu?Pro?Val

260 265 270

Asp?Leu?Val?Ala?Ala?Ser?Glu?Phe?Asn?Lys?Asp?Ala?Glu?Lys?Gln?Ile

275 280 285

Val?Asp?Leu?Asp?Ser?Ile?Pro?Glu?Gly?Trp?Met?Ser?Leu?Asp?Ile?Gly

290 295 300

Pro?Glu?Ser?Val?Lys?Asn?Phe?Gly?Glu?Val?Leu?Ser?Thr?Ala?Lys?Thr

305 310 315 320

Ile?Phe?Trp?Asn?Gly?Pro?Met?Gly?Val?Phe?Glu?Phe?Ala?Ala?Phe?Ser

325 330 335

Glu?Gly?Thr?Arg?Gly?Ile?Ala?Gln?Ala?Ile?Ile?Asp?Ala?Thr?Ala?Gly

340 345 350

Asn?Asp?Ala?Phe?Ser?Val?Val?Gly?Gly?Gly?Asp?Ser?Ala?Ala?Ser?Val

355 360 365

Arg?Val?Leu?Gly?Leu?Asn?Glu?Asp?Gly?Phe?Ser?His?Ile?Ser?Thr?Gly

370 375 380

Gly?Gly?Ala?Ser?Leu?Glu?Tyr?Leu?Glu?Gly?Lys?Glu?Leu?Pro?Gly?Val

385 390 395 400

Ala?Ile?Leu?Ala?Gln

405

<210>71

<211>1398

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1375)

<223>RXA00235

<400>71

cgaaacaaga?ttcgtgcaac?aattgggtgt?agacgtgatt?gaagacattt?gatcacgtga?60

ataattctag?ttagctccca?agttggcata?ggaggccaca?gtg?gct?gaa?atc?atg 115

Val?Ala?Glu?Ile?Met

1 5

cac?gta?ttc?gct?cgc?gaa?att?ctc?gac?tcc?cgc?ggt?aac?cca?acc?gtc 163

His?Val?Phe?Ala?Arg?Glu?Ile?Leu?Asp?Ser?Arg?Gly?Asn?Pro?Thr?Val

10 15 20

gag?gca?gag?gtt?ttc?ctg?gat?gac?ggt?tcc?cac?ggt?gtc?gca?ggt?gtt 211

Glu?Ala?Glu?Val?Phe?Leu?Asp?Asp?Gly?Ser?His?Gly?Val?Ala?Gly?Val

25 30 35

cca?tcc?ggc?gca?tcc?acc?ggc?gtc?cac?gag?gct?cat?gag?ctg?cgt?gac 259

Pro?Ser?Gly?Ala?Ser?Thr?Gly?Val?His?Glu?Ala?His?Glu?Leu?Arg?Asp

40 45 50

ggt?ggc?gat?cgc?tac?ctg?ggc?aag?ggc?gtt?ttg?aag?gca?gtt?gaa?aac 307

Gly?Gly?Asp?Arg?Tyr?Leu?Gly?Lys?Gly?Val?Leu?Lys?Ala?Val?Glu?Asn

55 60 65

gtc?aac?gaa?gaa?atc?ggc?gac?gag?ctc?gct?ggc?cta?gag?gct?gac?gat 355

Val?Asn?Glu?Glu?Ile?Gly?Asp?Glu?Leu?Ala?Gly?Leu?Glu?Ala?Asp?Asp

70 75 80 85

cag?cgc?ctc?atc?gac?gaa?gca?atg?atc?aag?ctt?gat?ggc?acc?gcc?aac 403

Gln?Arg?Leu?Ile?Asp?Glu?Ala?Met?Ile?Lys?Leu?Asp?Gly?Thr?Ala?Asn

90 95 100

aag?tcc?cgc?ctg?ggt?gca?aac?gca?atc?ctt?ggt?gtt?tcc?atg?gct?gtt 451

Lys?Ser?Arg?Leu?Gly?Ala?Asn?Ala?Ile?Leu?Gly?Val?Ser?Met?Ala?Val

105 110 115

gca?aag?gct?gct?gct?gat?tcc?gca?ggc?ctc?cca?ctg?ttc?cgc?tac?atc 499

Ala?Lys?Ala?Ala?Ala?Asp?Ser?Ala?Gly?Leu?Pro?Leu?Phe?Arg?Tyr?Ile

120 125 130

ggt?gga?cca?aac?gca?cac?gtt?ctt?cca?gtt?cca?atg?atg?aac?atc?atc 547

Gly?Gly?Pro?Asn?Ala?His?Val?Leu?Pro?Val?Pro?Met?Met?Asn?Ile?Ile

135 140 145

acc?ggt?ggc?gct?cac?gct?gac?tcc?ggt?gtt?gac?gtt?cag?gaa?ttc?atg 595

Thr?Gly?Gly?Ala?His?Ala?Asp?Ser?Gly?Val?Asp?Val?Gln?Glu?Phe?Met

150 155 160 165

atc?gct?cca?atc?ggt?gca?gag?acc?ttc?tct?gag?gct?ctc?cgc?aac?ggc 643

Ile?Ala?Pro?Ile?Gly?Ala?Glu?Thr?Phe?Ser?Glu?Ala?Leu?Arg?Asn?Gly

170 175 180

gcg?gag?gtc?tac?cac?gca?ctg?aag?tcc?gtc?atc?aag?gaa?aag?ggc?ctg 691

Ala?Glu?Val?Tyr?His?Ala?Leu?Lys?Ser?Val?Ile?Lys?Glu?Lys?Gly?Leu

185 190 195

tcc?acc?gga?ctt?ggc?gat?gag?ggc?ggc?ttc?gct?cct?tcc?gtc?ggc?tcc 739

Ser?Thr?Gly?Leu?Gly?Asp?Glu?Gly?Gly?Phe?Ala?Pro?Ser?Val?Gly?Ser

200 205 210

acc?cgt?gag?gct?ctt?gac?ctt?atc?gtt?gag?gca?atc?gag?aag?gct?ggc 787

Thr?Arg?Glu?Ala?Leu?Asp?Leu?Ile?Val?Glu?Ala?Ile?Glu?Lys?Ala?Gly

215 220 225

ttc?acc?cca?ggc?aag?gac?atc?gct?ctt?gct?ctg?gac?gtt?gct?tcc?tct 835

Phe?Thr?Pro?Gly?Lys?Asp?Ile?Ala?Leu?Ala?Leu?Asp?Val?Ala?Ser?Ser

230 235 240 245

gag?ttc?ttc?aag?gac?ggc?acc?tac?cac?ttc?gaa?ggt?ggc?cag?cac?tcc 883

Glu?Phe?Phe?Lys?Asp?Gly?Thr?Tyr?His?Phe?Glu?Gly?Gly?Gln?His?Ser

250 255 260

gca?gct?gag?atg?gca?aac?gtt?tac?gct?gag?ctc?gtt?gac?gcg?tac?cca 931

Ala?Ala?Glu?Met?Ala?Asn?Val?Tyr?Ala?Glu?Leu?Val?Asp?Ala?Tyr?Pro

265 270 275

atc?gtc?tcc?atc?gag?gac?cca?ctg?cag?gaa?gat?gac?tgg?gag?ggt?tac 979

Ile?Val?Ser?Ile?Glu?Asp?Pro?Leu?Gln?Glu?Asp?Asp?Trp?Glu?Gly?Tyr

280 285 290

acc?aac?ctc?acc?gca?acc?atc?ggc?gac?aag?gtt?cag?atc?gtt?ggc?gac 1027

Thr?Asn?Leu?Thr?Ala?Thr?Ile?Gly?Asp?Lys?Val?Gln?Ile?Val?Gly?Asp

295 300 305

gac?ttc?ttc?gtc?acc?aac?cct?gag?cgc?ctg?aag?gag?ggc?atc?gct?aag 1075

Asp?Phe?Phe?Val?Thr?Asn?Pro?Glu?Arg?Leu?Lys?Glu?Gly?Ile?Ala?Lys

310 315 320 325

aag?gct?gcc?aac?tcc?atc?ctg?gtt?aag?gtg?aac?cag?atc?ggt?acc?ctc 1123

Lys?Ala?Ala?Asn?Ser?Ile?Leu?Val?Lys?Val?Asn?Gln?Ile?Gly?Thr?Leu

330 335 340

acc?gag?acc?ttc?gac?gct?gtc?gac?atg?gct?cac?cgc?gca?ggc?tac?acc 1171

Thr?Glu?Thr?Phe?Asp?Ala?Val?Asp?Met?Ala?His?Arg?Ala?Gly?Tyr?Thr

345 350 355

tcc?atg?atg?tcc?cac?cgt?tcc?ggt?gag?acc?gag?gac?acc?acc?att?gct 1219

Ser?Met?Met?Ser?His?Arg?Ser?Gly?Glu?Thr?Glu?Asp?Thr?Thr?Ile?Ala

360 365 370

gac?ctc?gca?gtt?gca?ctc?aac?tgt?ggc?cag?atc?aag?act?ggt?gct?cca 1267

Asp?Leu?Ala?Val?Ala?Leu?Asn?Cys?Gly?Gln?Ile?Lys?Thr?Gly?Ala?Pro

375 380 385

gca?cgt?tcc?gac?cgt?gtc?gca?aag?tac?aac?cag?ctt?ctc?cgc?atc?gag 1315

Ala?Arg?Ser?Asp?Arg?Val?Ala?Lys?Tyr?Asn?Gln?Leu?Leu?Arg?Ile?Glu

390 395 400 405

cag?ctg?ctt?ggc?gac?gcc?ggc?gtc?tac?gca?ggt?cgc?agc?gca?ttc?cca 1363

Gln?Leu?Leu?Gly?Asp?Ala?Gly?Val?Tyr?Ala?Gly?Arg?Ser?Ala?Phe?Pro

410 415 420

cgc?ttt?cag?ggc?taaataaaag?cgcttttcga?cgc 1398

Arg?Phe?Gln?Gly

425

<210>72

<211>425

<212>PRT

＜213〉Corynebacterium glutamicum

<400>72

Val?Ala?Glu?Ile?Met?His?Val?Phe?Ala?Arg?Glu?Ile?Leu?Asp?Ser?Arg

1 5 10 15

Gly?Asn?Pro?Thr?Val?Glu?Ala?Glu?Val?Phe?Leu?Asp?Asp?Gly?Ser?His

20 25 30

Gly?Val?Ala?Gly?Val?Pro?Ser?Gly?Ala?Ser?Thr?Gly?Val?His?Glu?Ala

35 40 45

His?Glu?Leu?Arg?Asp?Gly?Gly?Asp?Arg?Tyr?Leu?Gly?Lys?Gly?Val?Leu

50 55 60

Lys?Ala?Val?Glu?Asn?Val?Asn?Glu?Glu?Ile?Gly?Asp?Glu?Leu?Ala?Gly

65 70 75 80

Leu?Glu?Ala?Asp?Asp?Gln?Arg?Leu?Ile?Asp?Glu?Ala?Met?Ile?Lys?Leu

85 90 95

Asp?Gly?Thr?Ala?Asn?Lys?Ser?Arg?Leu?Gly?Ala?Asn?Ala?Ile?Leu?Gly

100 105 110

Val?Ser?Met?Ala?Val?Ala?Lys?Ala?Ala?Ala?Asp?Ser?Ala?Gly?Leu?Pro

115 120 125

Leu?Phe?Arg?Tyr?Ile?Gly?Gly?Pro?Asn?Ala?His?Val?Leu?Pro?Val?Pro

130 135 140

Met?Met?Asn?Ile?Ile?Thr?Gly?Gly?Ala?His?Ala?Asp?Ser?Gly?Val?Asp

145 150 155 160

Val?Gln?Glu?Phe?Met?Ile?Ala?Pro?Ile?Gly?Ala?Glu?Thr?Phe?Ser?Glu

165 170 175

Ala?Leu?Arg?Asn?Gly?Ala?Glu?Val?Tyr?His?Ala?Leu?Lys?Ser?Val?Ile

180 185 190

Lys?Glu?Lys?Gly?Leu?Ser?Thr?Gly?Leu?Gly?Asp?Glu?Gly?Gly?Phe?Ala

195 200 205

Pro?Ser?Val?Gly?Ser?Thr?Arg?Glu?Ala?Leu?Asp?Leu?Ile?Val?Glu?Ala

210 215 220

Ile?Glu?Lys?Ala?Gly?Phe?Thr?Pro?Gly?Lys?Asp?Ile?Ala?Leu?Ala?Leu

225 230 235 240

Asp?Val?Ala?Ser?Ser?Glu?Phe?Phe?Lys?Asp?Gly?Thr?Tyr?His?Phe?Glu

245 250 255

Gly?Gly?Gln?His?Ser?Ala?Ala?Glu?Met?Ala?Asn?Val?Tyr?Ala?Glu?Leu

260 265 270

Val?Asp?Ala?Tyr?Pro?Ile?Val?Ser?Ile?Glu?Asp?Pro?Leu?Gln?Glu?Asp

275 280 285

Asp?Trp?Glu?Gly?Tyr?Thr?Asn?Leu?Thr?Ala?Thr?Ile?Gly?Asp?Lys?Val

290 295 300

Gln?Ile?Val?Gly?Asp?Asp?Phe?Phe?Val?Thr?Asn?Pro?Glu?Arg?Leu?Lys

305 310 315 320

Glu?Gly?Ile?Ala?Lys?Lys?Ala?Ala?Asn?Ser?Ile?Leu?Val?Lys?Val?Asn

325 330 335

Gln?Ile?Gly?Thr?Leu?Thr?Glu?Thr?Phe?Asp?Ala?Val?Asp?Met?Ala?His

340 345 350

Arg?Ala?Gly?Tyr?Thr?Ser?Met?Met?Ser?His?Arg?Ser?Gly?Glu?Thr?Glu

355 360 365

Asp?Thr?Thr?Ile?Ala?Asp?Leu?Ala?Val?Ala?Leu?Asn?Cys?Gly?Gln?Ile

370 375 380

Lys?Thr?Gly?Ala?Pro?Ala?Arg?Ser?Asp?Arg?Val?Ala?Lys?Tyr?Asn?Gln

385 390 395 400

Leu?Leu?Arg?Ile?Glu?Gln?Leu?Leu?Gly?Asp?Ala?Gly?Val?Tyr?Ala?Gly

405 410 415

Arg?Ser?Ala?Phe?Pro?Arg?Phe?Gln?Gly

420 425

<210>73

<211>1554

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1531)

<223>RXA01093

<400>73

cagaggcgta?gaacattgtc?tgttcacact?ctgggtcgca?agattcatcg?agaattaatg?60

gtagtacctg?tggcttgagg?gggaatgacg?tactaggctt?atg?ggc?gtg?gat?aga 115

Met?Gly?Val?Asp?Arg

1 5

cga?act?aag?att?gta?tgt?acc?cra?ggc?cca?gcg?gtg?gct?agt?gca?gat 163

Arg?Thr?Lys?Ile?Val?Cys?Thr?Leu?Gly?Pro?Ala?Val?Ala?Ser?Ala?Asp

10 15 20

gga?att?ctg?cgt?ttg?gta?gaa?gac?ggc?atg?gat?gtt?gct?cgc?ctc?aac 211

Gly?Ile?Leu?Arg?Leu?Val?Glu?Asp?Gly?Met?Asp?Val?Ala?Arg?Leu?Asn

25 30 35

ttc?tcc?cat?ggt?gac?cac?cca?gat?cat?gag?caa?aac?tac?aag?tgg?gtc 259

Phe?Ser?His?Gly?Asp?His?Pro?Asp?His?Glu?Gln?Asn?Tyr?Lys?Trp?Val

40 45 50

cgc?gag?gcg?gcg?gag?aag?act?ggc?cgt?gca?gtc?ggt?att?ctc?gca?gac 307

Arg?Glu?Ala?Ala?Glu?Lys?Thr?Gly?Arg?Ala?Val?Gly?Ile?Leu?Ala?Asp

55 60 65

ctc?caa?gga?ccg?aag?atc?cgt?ctt?ggc?cgt?ttc?act?gac?ggc?gca?acc 355

Leu?Gln?Gly?Pro?Lys?Ile?Arg?Leu?Gly?Arg?Phe?Thr?Asp?Gly?Ala?Thr

70 75 80 85

gtg?tgg?gaa?aac?ggc?gag?acc?att?cgg?atc?acc?gtt?gac?gat?gta?gag 403

Val?Trp?Glu?Asn?Gly?Glu?Thr?Ile?Arg?Ile?Thr?Val?Asp?Asp?Val?Glu

90 95 100

gga?acg?cac?gat?cgt?gtg?tcc?acc?acc?tac?aag?aat?ctg?gca?aaa?gac 451

Gly?Thr?His?Asp?Arg?Val?Ser?Thr?Thr?Tyr?Lys?Asn?Leu?Ala?Lys?Asp

105 110 115

gcg?aag?cca?ggc?gac?cgc?ctg?ctc?gtt?gat?gac?ggc?aag?gtt?ggc?ctc 499

Ala?Lys?Pro?Gly?Asp?Arg?Leu?Leu?Val?Asp?Asp?Gly?Lys?Val?Gly?Leu

120 125 130

gtc?tgc?gtt?tcc?gtc?gaa?ggt?aac?gac?gtc?atc?tgt?gag?gtt?gtt?gag 547

Val?Cys?Val?Ser?Val?Glu?Gly?Asn?Asp?Val?Ile?Cys?Glu?Val?Val?Glu

135 140 145

ggc?gga?cca?gtc?tcc?aac?aac?aag?ggt?gtt?tcc?ctg?cca?ggt?atg?gat 595

Gly?Gly?Pro?Val?Ser?Asn?Asn?Lys?Gly?Val?Ser?Leu?Pro?Gly?Met?Asp

150 155 160 165

att?tcc?gta?cct?gca?ctg?tcc?gaa?aag?gat?atc?cgt?gac?ctg?cgc?ttc 643

Ile?Ser?Val?Pro?Ala?Leu?Ser?Glu?Lys?Asp?Ile?Arg?Asp?Leu?Arg?Phe

170 175 180

gcc?ctg?aag?ctc?ggc?gtg?gac?ttt?att?gca?ctg?tcc?ttc?gta?cgt?tcc 691

Ala?Leu?Lys?Leu?Gly?Val?Asp?Phe?Ile?Ala?Leu?Ser?Phe?Val?Arg?Ser

185 190 195

cca?gca?gat?gct?gaa?ctc?gtt?cac?aag?atc?atg?gac?gaa?gaa?ggt?cgt 739

Pro?Ala?Asp?Ala?Glu?Leu?Val?His?Lys?Ile?Met?Asp?Glu?Glu?Gly?Arg

200 205 210

cgt?gtt?cct?gtg?atc?gcc?aag?ctg?gaa?aag?cca?gag?gct?gtc?acc?tcc 787

Arg?Val?Pro?Val?Ile?Ala?Lys?Leu?Glu?Lys?Pro?Glu?Ala?Val?Thr?Ser

215 220 225

ctc?gag?cca?atc?gtg?ttg?gca?ttc?gac?gcc?gtc?atg?gtt?gct?cgt?ggt 835

Leu?Glu?Pro?Ile?Val?Leu?Ala?Phe?Asp?Ala?Val?Met?Val?Ala?Arg?Gly

230 235 240 245

gac?ctc?ggc?gtt?gag?gtt?cct?ctg?gag?gag?gtt?cca?ctg?gtt?cag?aag 883

Asp?Leu?Gly?Val?Glu?Val?Pro?Leu?Glu?Glu?Val?Pro?Leu?Val?Gln?Lys

250 255 260

cgc?gca?atc?cag?att?gcc?cgt?gag?aac?gca?aag?cca?gtt?atc?gtg?gca 931

Arg?Ala?Ile?Gln?Ile?Ala?Arg?Glu?Asn?Ala?Lys?Pro?Val?Ile?Val?Ala

265 270 275

acc?cag?atg?ctg?gat?tcc?atg?att?gag?aac?tcc?cgc?cca?acc?cgt?gcg 979

Thr?Gln?Met?Leu?Asp?Ser?Met?Ile?Glu?Asn?Ser?Arg?Pro?Thr?Arg?Ala

280 285 290

gaa?gct?tct?gac?gtg?gca?aac?gct?gtg?ctc?gat?ggc?gca?gat?gct?gtc 1027

Glu?Ala?Ser?Asp?Val?Ala?Asn?Ala?Val?Leu?Asp?Gly?Ala?Asp?Ala?Val

295 300 305

atg?ctt?tct?ggt?gaa?act?tca?gtg?ggc?aaa?gat?ccg?cac?aac?gtt?gtg 1075

Met?Leu?Ser?Gly?Glu?Thr?Ser?Val?Gly?Lys?Asp?Pro?His?Asn?Val?Val

310 315 320 325

cgc?acc?atg?tct?cgc?att?gtt?cgc?ttc?gct?gaa?acc?gac?ggt?cgc?gtc 1123

Arg?Thr?Met?Ser?Arg?Ile?Val?Arg?Phe?Ala?Glu?Thr?Asp?Gly?Arg?Val

330 335 340

cca?gac?ctg?acc?cac?atc?cct?cgc?act?aag?cgt?ggc?gtt?att?tcc?tac 1171

Pro?Asp?Leu?Thr?His?Ile?Pro?Arg?Thr?Lys?Arg?Gly?Val?Ile?Ser?Tyr

345 350 355

tct?gca?cgt?gat?atc?gcc?gag?cgc?ctc?aac?gct?cgt?gca?ttg?gtt?gcg 1219

Ser?Ala?Arg?Asp?Ile?Ala?Glu?Arg?Leu?Asn?Ala?Arg?Ala?Leu?Val?Ala

360 365 370

ttc?acc?acc?tct?ggt?gat?acc?gca?aag?cgt?gtg?gct?cgt?ctg?cac?agc 1267

Phe?Thr?Thr?Ser?Gly?Asp?Thr?Ala?Lys?Arg?Val?Ala?Arg?Leu?His?Ser

375 380 385

cac?ctg?cca?ctg?ctc?gtg?ttc?act?cca?aat?gag?gca?gtt?cgc?tct?gag 1315

His?Leu?Pro?Leu?Leu?Val?Phe?Thr?Pro?Asn?Glu?Ala?Val?Arg?Ser?Glu

390 395 400 405

ctg?gcg?ctg?acc?tgg?ggt?gca?acc?acc?ttc?ctg?tgt?cca?cct?gtc?agc 1363

Leu?Ala?Leu?Thr?Trp?Gly?Ala?Thr?Thr?Phe?Leu?Cys?Pro?Pro?Val?Ser

410 415 420

gat?acc?gat?gac?atg?atg?cgc?gaa?gtc?gac?cgt?gct?crt?tta?gca?atg 1411

Asp?Thr?Asp?Asp?Met?Met?Arg?Glu?Val?Asp?Arg?Ala?Leu?Leu?Ala?Met

425 430 435

cct?gag?tac?aac?aag?ggt?gac?atg?atg?gtt?gtt?gtt?gca?ggt?tcc?cct 1459

Pro?Glu?Tyr?Asn?Lys?Gly?Asp?Met?Met?Val?Val?Val?Ala?Gly?Ser?Pro

440 445 450

cct?ggt?gtt?acc?ggt?aac?acc?aac?atg?att?cac?gtc?cac?ctt?ctt?ggt 1507

Pro?Gly?Val?Thr?Gly?Asn?Thr?Asn?Met?Ile?His?Val?His?Leu?Leu?Gly

455 460 465

gac?gac?aca?agg?att?gca?aag?ctc?taatcgctta?aatctttcaa?aaa 1554

Asp?Asp?Thr?Arg?Ile?Ala?Lys?Leu

470 475

<210>74

<211>477

<212>PRT

＜213〉Corynebacterium glutamicum

<400>74

Met?Gly?Val?Asp?Arg?Arg?Thr?Lys?Ile?Val?Cys?Thr?Leu?Gly?Pro?Ala

1 5 10 15

Val?Ala?Ser?Ala?Asp?Gly?Ile?Leu?Arg?Leu?Val?Glu?Asp?Gly?Met?Asp

20 25 30

Val?Ala?Arg?Leu?Asn?Phe?Ser?His?Gly?Asp?His?Pro?Asp?His?Glu?Gln

35 40 45

Asn?Tyr?Lys?Trp?Val?Arg?Glu?Ala?Ala?Glu?Lys?Thr?Gly?Arg?Ala?Val

50 55 60

Gly?Ile?Leu?Ala?Asp?Leu?Gln?Gly?Pro?Lys?Ile?Arg?Leu?Gly?Arg?Phe

65 70 75 80

Thr?Asp?Gly?Ala?Thr?Val?Trp?Glu?Asn?Gly?Glu?Thr?Ile?Arg?Ile?Thr

85 90 95

Val?Asp?Asp?Val?Glu?Gly?Thr?His?Asp?Arg?Val?Ser?Thr?Thr?Tyr?Lys

100 105 110

Asn?Leu?Ala?Lys?Asp?Ala?Lys?Pro?Gly?Asp?Arg?Leu?Leu?Val?Asp?Asp

115 120 125

Gly?Lys?Val?Gly?Leu?Val?Cys?Val?Ser?Val?Glu?Gly?Asn?Asp?Val?Ile

130 135 140

Cys?Glu?Val?Val?Glu?Gly?Gly?Pro?Val?Ser?Asn?Asn?Lys?Gly?Val?Ser

145 150 155 160

Leu?Pro?Gly?Met?Asp?Ile?Ser?Val?Pro?Ala?Leu?Ser?Glu?Lys?Asp?Ile

165 170 175

Arg?Asp?Leu?Arg?Phe?Ala?Leu?Lys?Leu?Gly?Val?Asp?Phe?Ile?Ala?Leu

180 185 190

Ser?Phe?Val?Arg?Ser?Pro?Ala?Asp?Ala?Glu?Leu?Val?His?Lys?Ile?Met

195 200 205

Asp?Glu?Glu?Gly?Arg?Arg?Val?Pro?Val?Ile?Ala?Lys?Leu?Glu?Lys?Pro

210 215 220

Glu?Ala?Val?Thr?Ser?Leu?Glu?Pro?Ile?Val?Leu?Ala?Phe?Asp?Ala?Val

225 230 235 240

Met?Val?Ala?Arg?Gly?Asp?Leu?Gly?Val?Glu?Val?Pro?Leu?Glu?Glu?Val

245 250 255

Pro?Leu?Val?Gln?Lys?Arg?Ala?Ile?Gln?Ile?Ala?Arg?Glu?Asn?Ala?Lys

260 265 270

Pro?Val?Ile?Val?Ala?Thr?Gln?Met?Leu?Asp?Ser?Met?Ile?Glu?Asn?Ser

275 280 285

Arg?Pro?Thr?Arg?Ala?Glu?Ala?Ser?Asp?Val?Ala?Asn?Ala?Val?Leu?Asp

290 295 300

Gly?Ala?Asp?Ala?Val?Met?Leu?Ser?Gly?Glu?Thr?Ser?Val?Gly?Lys?Asp

305 310 315 320

Pro?His?Asn?Val?Val?Arg?Thr?Met?Ser?Arg?Ile?Val?Arg?Phe?Ala?Glu

325 330 335

Thr?Asp?Gly?Arg?Val?Pro?Asp?Leu?Thr?His?Ile?Pro?Arg?Thr?Lys?Arg

340 345 350

Gly?Val?Ile?Ser?Tyr?Ser?Ala?Arg?Asp?Ile?Ala?Glu?Arg?Leu?Asn?Ala

355 360 365

Arg?Ala?Leu?Val?Ala?Phe?Thr?Thr?Ser?Gly?Asp?Thr?Ala?Lys?Arg?Val

370 375 380

Ala?Arg?Leu?His?Ser?His?Leu?Pro?Leu?Leu?Val?Phe?Thr?Pro?Asn?Glu

385 390 395 400

Ala?Val?Arg?Ser?Glu?Leu?Ala?Leu?Thr?Trp?Gly?Ala?Thr?Thr?Phe?Leu

405 410 415

Cys?Pro?Pro?Val?Ser?Asp?Thr?Asp?Asp?Met?Met?Arg?Glu?Val?Asp?Arg

420 425 430

Ala?Leu?Leu?Ala?Met?Pro?Glu?Tyr?Asn?Lys?Gly?Asp?Met?Met?Val?Val

435 440 445

Val?Ala?Gly?Ser?Pro?Pro?Gly?Val?Thr?Gly?Asn?Thr?Asn?Met?Ile?His

450 455 460

Val?His?Leu?Leu?Gly?Asp?Asp?Thr?Arg?Ile?Ala?Lys?Leu

465 470 475

<210>75

<211>1980

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1957)

<223>RXN02675

<400>75

aagtgtttca?ttggaacact?tgcgctgcca?actttttggt?ttacgggcac?aatgaaactg?60

ttggatggaa?tttagagtgt?ttgtagctta?aggagctcaa?atg?aat?gag?ttt?gac 115

Met?Asn?Glu?Phe?Asp

1 5

cag?gac?att?ctc?cag?gag?atc?aag?act?gaa?ctc?gac?gag?tta?att?cta 163

Gln?Asp?Ile?Leu?Gln?Glu?Ile?Lys?Thr?Glu?Leu?Asp?Glu?Leu?Ile?Leu

10 15 20

gaa?ctt?gat?gag?gtg?aca?caa?act?cac?agc?gag?gcc?atc?ggg?cag?gtc 211

Glu?Leu?Asp?Glu?Val?Thr?Gln?Thr?His?Ser?Glu?Ala?Ile?Gly?Gln?Val

25 30 35

tcc?cca?acc?cat?tac?gtt?ggt?gcc?cgc?aac?ctc?atg?cat?tac?gcg?cat 259

Ser?Pro?Thr?His?Tyr?Val?Gly?Ala?Arg?Asn?Leu?Met?His?Tyr?Ala?His

40 45 50

ctt?cgc?acc?aaa?gac?ctc?cgt?ggc?ctg?cag?caa?cgc?ctc?tcc?tct?gtg 307

Leu?Arg?Thr?Lys?Asp?Leu?Arg?Gly?Leu?Gln?Gln?Arg?Leu?Ser?Ser?Val

55 60 65

gga?gct?acc?cgc?ttg?act?acc?acc?gaa?cca?gca?gtg?cag?gcc?cgc?ctc 355

Gly?Ala?Thr?Arg?Leu?Thr?Thr?Thr?Glu?Pro?Ala?Val?Gln?Ala?Arg?Leu

70 75 80 85

aag?gcc?gcc?cgc?aat?gtt?atc?gga?gct?ttc?gca?ggt?gaa?ggc?cca?ctt 403

Lys?Ala?Ala?Arg?Asn?Val?Ile?Gly?Ala?Phe?Ala?Gly?Glu?Gly?Pro?Leu

90 95 100

tat?cca?ccc?tca?gat?gtc?gtc?gat?gcc?ttc?gaa?gat?gcc?gat?gag?att 451

Tyr?Pro?Pro?Ser?Asp?Val?Val?Asp?Ala?Phe?Glu?Asp?Ala?Asp?Glu?Ile

105 110 115

ctc?gac?gag?cac?gcc?gaa?att?ctc?ctt?ggc?gaa?ccc?cta?ccg?gat?act 499

Leu?Asp?Glu?His?Ala?Glu?Ile?Leu?Leu?Gly?Glu?Pro?Leu?Pro?Asp?Thr

120 125 130

cca?tcc?tgc?atc?atg?gtc?acc?ctg?ccc?acc?gaa?gcc?gcc?acc?gac?att 547

Pro?Ser?Cys?Ile?Met?Val?Thr?Leu?Pro?Thr?Glu?Ala?Ala?Thr?Asp?Ile

135 140 145

gaa?ctt?gtc?cgt?ggc?ttc?gcc?aaa?agc?ggc?atg?aat?cta?gct?cgc?atc 595

Glu?Leu?Val?Arg?Gly?Phe?Ala?Lys?Ser?Gly?Met?Asn?Leu?Ala?Arg?Ile

150 155 160 165

aac?tgt?gca?cac?gac?gat?gaa?acc?gtc?tgg?aag?cag?atg?atc?gac?aac 643

Asn?Cys?Ala?His?Asp?Asp?Glu?Thr?Val?Trp?Lys?Gln?Met?Ile?Asp?Asn

170 175 180

gtc?cac?acc?gtt?gca?gaa?gaa?gtt?ggc?cgg?gaa?atc?cgc?gtc?agc?atg 691

Val?His?Thr?Val?Ala?Glu?Glu?Val?Gly?Arg?Glu?Ile?Arg?Val?Ser?Met

185 190 195

gac?ctc?gcc?gga?cca?aaa?gta?cgc?acc?ggc?gaa?atc?gcc?cca?ggc?gca 739

Asp?Leu?Ala?Gly?Pro?Lys?Val?Arg?Thr?Gly?Glu?Ile?Ala?Pro?Gly?Ala

200 205 210

gaa?gta?ggt?cgc?gca?cga?gta?acc?cgc?gac?gaa?acc?gga?aaa?gta?ctg 787

Glu?Val?Gly?Arg?Ala?Arg?Val?Thr?Arg?Asp?Glu?Thr?Gly?Lys?Val?Leu

215 220 225

acg?ccc?gca?aaa?ctg?tgg?atc?acc?gcc?cac?ggc?tcc?gaa?cca?gtc?cca 835

Thr?Pro?Ala?Lys?Leu?Trp?Ile?Thr?Ala?His?Gly?Ser?Glu?Pro?Val?Pro

230 235 240 245

gcc?ccc?gaa?agc?ctg?ccc?ggt?cgc?ccc?gct?ctg?ccg?att?gaa?gtc?acc 883

Ala?Pro?Glu?Ser?Leu?Pro?Gly?Arg?Pro?Ala?Leu?Pro?Ile?Glu?Val?Thr

250 255 260

cca?gaa?tgg?ttc?gac?aaa?cta?gaa?atc?ggc?agc?gtc?atc?aac?gtc?cca 931

Pro?Glu?Trp?Phe?Asp?Lys?Leu?Glu?Ile?Gly?Ser?Val?Ile?Asn?Val?Pro

265 270 275

gac?acc?cgc?gga?tcc?cgc?cga?gca?ttc?acc?gtg?acc?agg?gtt?ttt?gat 979

Asp?Thr?Arg?Gly?Ser?Arg?Arg?Ala?Phe?Thr?Val?Thr?Arg?Val?Phe?Asp

280 285 290

ggc?gcg?gtc?ctc?gcc?gaa?ggc?cca?caa?aaa?gcc?tac?atc?tcc?aac?ggc 1027

Gly?Ala?Val?Leu?Ala?Glu?Gly?Pro?Gln?Lys?Ala?Tyr?Ile?Ser?Asn?Gly

295 300 305

acc?ctc?ctg?gaa?cac?aac?tac?gac?cgc?tcc?cgg?gtc?tac?ggc?atc?ccc 1075

Thr?Leu?Leu?Glu?His?Asn?Tyr?Asp?Arg?Ser?Arg?Val?Tyr?Gly?Ile?Pro

310 315 320 325

gcc?gta?gtt?cag?cgc?atc?aac?ctc?aaa?gtc?ggc?gac?cgc?ctc?atc?ctt 1123

Ala?Val?Val?Gln?Arg?Ile?Asn?Leu?Lys?Val?Gly?Asp?Arg?Leu?Ile?Leu

330 335 340

acc?gac?gaa?gaa?ctc?acc?tac?gat?cca?tcc?ctc?gga?tcc?ggc?cgc?aca 1171

Thr?Asp?Glu?Glu?Leu?Thr?Tyr?Asp?Pro?Ser?Leu?Gly?Ser?Gly?Arg?Thr

345 350 355

cca?cgc?atc?agc?tgc?acc?ctt?cca?caa?gca?gtc?gat?gca?att?aaa?gtc 1219

Pro?Arg?Ile?Ser?Cys?Thr?Leu?Pro?Gln?Ala?Val?Asp?Ala?Ile?Lys?Val

360 365 370

ggg?cac?cgc?gtg?ctt?ttc?gac?gac?gga?gcc?atc?gcc?gca?gtc?tgc?atc 1267

Gly?His?Arg?Val?Leu?Phe?Asp?Asp?Gly?Ala?Ile?Ala?Ala?Val?Cys?Ile

375 380 385

gac?aag?acc?tcc?act?gcc?gac?ggc?cac?aac?gac?gta?gaa?ttg?gaa?gtc 1315

Asp?Lys?Thr?Ser?Thr?Ala?Asp?Gly?His?Asn?Asp?Val?Glu?Leu?Glu?Val

390 395 400 405

acc?cac?gcc?cgc?cca?caa?ggc?gta?aac?ctg?gcc?gca?tac?aag?gga?atc 1363

Thr?His?Ala?Arg?Pro?Gln?Gly?Val?Asn?Leu?Ala?Ala?Tyr?Lys?Gly?Ile

410 415 420

aac?ctc?cca?gac?tcc?gaa?ctt?cca?ctc?cca?agc?ctc?act?gaa?gaa?gac 1411

Asn?Leu?Pro?Asp?Ser?Glu?Leu?Pro?Leu?Pro?Ser?Leu?Thr?Glu?Glu?Asp

425 430 435

ctc?caa?cac?ctg?cgc?ttt?gtc?gtc?aaa?tac?gcc?gac?atc?gca?gcc?atc 1459

Leu?Gln?His?Leu?Arg?Phe?Val?Val?Lys?Tyr?Ala?Asp?Ile?Ala?Ala?Ile

440 445 450

tcc?ttc?atc?cga?aac?gtc?gcc?gac?gtg?gaa?tac?ctc?ctc?caa?gca?ctc 1507

Ser?Phe?Ile?Arg?Asn?Val?Ala?Asp?Val?Glu?Tyr?Leu?Leu?Gln?Ala?Leu

455 460 465

gcc?gac?atc?gga?gat?cca?gta?gcc?gtc?gaa?cgc?ctt?ggc?ctc?gtc?ctt 1555

Ala?Asp?Ile?Gly?Asp?Pro?Val?Ala?Val?Glu?Arg?Leu?Gly?Leu?Val?Leu

470 475 480 485

aaa?atc?gag?acc?atc?cca?ggc?tac?gaa?ggc?ctc?gcc?caa?atc?ctc?ctg 1603

Lys?Ile?Glu?Thr?Ile?Pro?Gly?Tyr?Glu?Gly?Leu?Ala?Gln?Ile?Leu?Leu

490 495 500

acc?ggc?atg?cgc?cac?gaa?aac?ttc?ggc?atc?atg?atc?gcc?cgc?gga?gac 1651

Thr?Gly?Met?Arg?His?Glu?Asn?Phe?Gly?Ile?Met?Ile?Ala?Arg?Gly?Asp

505 510 515

ctc?gcc?gtc?gaa?ctc?ggc?ttc?gac?cgc?atg?gca?gaa?gtc?ccc?caa?ctg 1699

Leu?Ala?Val?Glu?Leu?Gly?Phe?Asp?Arg?Met?Ala?Glu?Val?Pro?Gln?Leu

520 525 530

atc?atg?gcc?ctt?gcc?gaa?gcc?gcc?cac?gtc?cca?acc?atc?ttg?gcc?acc 1747

Ile?Met?Ala?Leu?Ala?Glu?Ala?Ala?His?Val?Pro?Thr?Ile?Leu?Ala?Thr

535 540 545

caa?gtc?ctg?gaa?aac?atg?gcc?aaa?aac?gga?ctc?cca?tct?cgc?gca?gaa 1795

Gln?Val?Leu?Glu?Asn?Met?Ala?Lys?Asn?Gly?Leu?Pro?Ser?Arg?Ala?Glu

550 555 560 565

atc?acc?gac?gca?gca?atg?gca?ctt?cgc?gct?gaa?tgc?gtc?atg?ctg?aac 1843

Ile?Thr?Asp?Ala?Ala?Met?Ala?Leu?Arg?Ala?Glu?Cys?Val?Met?Leu?Asn

570 575 580

aag?gga?cca?cac?atc?aac?gac?gcc?atc?aag?gtc?ctc?acc?gaa?atg?agc 1891

Lys?Gly?Pro?His?Ile?Asn?Asp?Ala?Ile?Lys?Val?Leu?Thr?Glu?Met?Ser

585 590 595

cgc?aaa?ctt?ggt?gca?tcc?caa?cga?aag?agt?agg?ctg?ctg?ctg?cgc?aag 1939

Arg?Lys?Leu?Gly?Ala?Ser?Gln?Arg?Lys?Ser?Arg?Leu?Leu?Leu?Arg?Lys

600 605 610

gtg?aag?agc?tgg?gaa?gag?taactcacaa?aggcgattgg?cgt 1980

Val?Lys?Ser?Trp?Glu?Glu

615

<210>76

<211>619

<212>PRT

＜213〉Corynebacterium glutamicum

<400>76

Met?Asn?Glu?Phe?Asp?Gln?Asp?Ile?Leu?Gln?Glu?Ile?Lys?Thr?Glu?Leu

1 5 10 15

Asp?Glu?Leu?Ile?Leu?Glu?Leu?Asp?Glu?Val?Thr?Gln?Thr?His?Ser?Glu

20 25 30

Ala?Ile?Gly?Gln?Val?Ser?Pro?Thr?His?Tyr?Val?Gly?Ala?Arg?Asn?Leu

35 40 45

Met?His?Tyr?Ala?His?Leu?Arg?Thr?Lys?Asp?Leu?Arg?Gly?Leu?Gln?Gln

50 55 60

Arg?Leu?Ser?Ser?Val?Gly?Ala?Thr?Arg?Leu?Thr?Thr?Thr?Glu?Pro?Ala

65 70 75 80

Val?Gln?Ala?Arg?Leu?Lys?Ala?Ala?Arg?Asn?Val?Ile?Gly?Ala?Phe?Ala

85 90 95

Gly?Glu?Gly?Pro?Leu?Tyr?Pro?Pro?Ser?Asp?Val?Val?Asp?Ala?Phe?Glu

100 105 110

Asp?Ala?Asp?Glu?Ile?Leu?Asp?Glu?His?Ala?Glu?Ile?Leu?Leu?Gly?Glu

115 120 125

Pro?Leu?Pro?Asp?Thr?Pro?Ser?Cys?Ile?Met?Val?Thr?Leu?Pro?Thr?Glu

130 135 140

Ala?Ala?Thr?Asp?Ile?Glu?Leu?Val?Arg?Gly?Phe?Ala?Lys?Ser?Gly?Met

145 150 155 160

Asn?Leu?Ala?Arg?Ile?Asn?Cys?Ala?His?Asp?Asp?Glu?Thr?Val?Trp?Lys

165 170 175

Gln?Met?Ile?Asp?Asn?Val?His?Thr?Val?Ala?Glu?Glu?Val?Gly?Arg?Glu

180 185 190

Ile?Arg?Val?Ser?Met?Asp?Leu?Ala?Gly?Pro?Lys?Val?Arg?Thr?Gly?Glu

195 200 205

Ile?Ala?Pro?Gly?Ala?Glu?Val?Gly?Arg?Ala?Arg?Val?Thr?Arg?Asp?Glu

210 215 220

Thr?Gly?Lys?Val?Leu?Thr?Pro?Ala?Lys?Leu?Trp?Ile?Thr?Ala?His?Gly

225 230 235 240

Ser?Glu?Pro?Val?Pro?Ala?Pro?Glu?Ser?Leu?Pro?Gly?Arg?Pro?Ala?Leu

245 250 255

Pro?Ile?Glu?Val?Thr?Pro?Glu?Trp?Phe?Asp?Lys?Leu?Glu?Ile?Gly?Ser

260 265 270

Val?Ile?Asn?Val?Pro?Asp?Thr?Arg?Gly?Ser?Arg?Arg?Ala?Phe?Thr?Val

275 280 285

Thr?Arg?Val?Phe?Asp?Gly?Ala?Val?Leu?Ala?Glu?Gly?Pro?Gln?Lys?Ala

290 295 300

Tyr?Ile?Ser?Asn?Gly?Thr?Leu?Leu?Glu?His?Asn?Tyr?Asp?Arg?Ser?Arg

305 310 315 320

Val?Tyr?Gly?Ile?Pro?Ala?Val?Val?Gln?Arg?Ile?Asn?Leu?Lys?Val?Gly

325 330 335

Asp?Arg?Leu?Ile?Leu?Thr?Asp?Glu?Glu?Leu?Thr?Tyr?Asp?Pro?Ser?Leu

340 345 350

Gly?Ser?Gly?Arg?Thr?Pro?Arg?Ile?Ser?Cys?Thr?Leu?Pro?Gln?Ala?Val

355 360 365

Asp?Ala?Ile?Lys?Val?Gly?His?Arg?Val?Leu?Phe?Asp?Asp?Gly?Ala?Ile

370 375 380

Ala?Ala?Val?Cys?Ile?Asp?Lys?Thr?Ser?Thr?Ala?Asp?Gly?His?Asn?Asp

385 390 395 400

Val?Glu?Leu?Glu?Val?Thr?His?Ala?Arg?Pro?Gln?Gly?Val?Asn?Leu?Ala

405 410 415

Ala?Tyr?Lys?Gly?Ile?Asn?Leu?Pro?Asp?Ser?Glu?Leu?Pro?Leu?Pro?Ser

420 425 430

Leu?Thr?Glu?Glu?Asp?Leu?Gln?His?Leu?Arg?Phe?Val?Val?Lys?Tyr?Ala

435 440 445

Asp?Ile?Ala?Ala?Ile?Ser?Phe?Ile?Arg?Asn?Val?Ala?Asp?Val?Glu?Tyr

450 455 460

Leu?Leu?Gln?Ala?Leu?Ala?Asp?Ile?Gly?Asp?Pro?Val?Ala?Val?Glu?Arg

465 470 475 480

Leu?Gly?Leu?Val?Leu?Lys?Ile?Glu?Thr?Ile?Pro?Gly?Tyr?Glu?Gly?Leu

485 490 495

Ala?Gln?Ile?Leu?Leu?Thr?Gly?Met?Arg?His?Glu?Asn?Phe?Gly?Ile?Met

500 505 510

Ile?Ala?Arg?Gly?Asp?Leu?Ala?Val?Glu?Leu?Gly?Phe?Asp?Arg?Met?Ala

515 520 525

Glu?Val?Pro?Gln?Leu?Ile?Met?Ala?Leu?Ala?Glu?Ala?Ala?His?Val?Pro

530 535 540

Thr?Ile?Leu?Ala?Thr?Gln?Val?Leu?Glu?Asn?Met?Ala?Lys?Asn?Gly?Leu

545 550 555 560

Pro?Ser?Arg?Ala?Glu?Ile?Thr?Asp?Ala?Ala?Met?Ala?Leu?Arg?Ala?Glu

565 570 575

Cys?Val?Met?Leu?Asn?Lys?Gly?Pro?His?Ile?Asn?Asp?Ala?Ile?Lys?Val

580 585 590

Leu?Thr?Glu?Met?Ser?Arg?Lys?Leu?Gly?Ala?Ser?Gln?Arg?Lys?Ser?Arg

595 600 605

Leu?Leu?Leu?Arg?Lys?Val?Lys?Ser?Trp?Glu?Glu

610 615

<210>77

<211>386

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(363)

<223>FRXA02675

<400>77

atc?ctc?atg?acc?ggc?atg?cgc?cac?gaa?aac?ttc?ggc?atc?atg?atc?gcc 48

Ile?Leu?Met?Thr?Gly?Met?Arg?His?Glu?Asn?Phe?Gly?Ile?Met?Ile?Ala

1 5 10 15

cgc?gga?gac?ctc?gcc?gtc?gaa?ctc?ggc?ttc?gac?cgc?atg?gca?gaa?gtc 96

Arg?Gly?Asp?Leu?Ala?Val?Glu?Leu?Gly?Phe?Asp?Arg?Met?Ala?Glu?Val

20 25 30

ccc?caa?ctg?atc?atg?gcc?ctt?gca?gaa?gcc?gcc?cac?gtc?cca?acc?atc 144

Pro?Gln?Leu?Ile?Met?Ala?Leu?Ala?Glu?Ala?Ala?His?Val?Pro?Thr?Ile

35 40 45

ttg?gcc?acc?caa?gtc?ctg?gaa?aac?atg?gcc?aaa?aac?gga?ctc?cca?tct 192

Leu?Ala?Thr?Gln?Val?Leu?Glu?Asn?Met?Ala?Lys?Asn?Gly?Leu?Pro?Ser

50 55 60

cgc?gca?gaa?atc?acc?gac?gca?gca?atg?gca?ctt?cgc?gct?gaa?tgc?gtc 240

Arg?Ala?Glu?Ile?Thr?Asp?Ala?Ala?Met?Ala?Leu?Arg?Ala?Glu?Cys?Val

65 70 75 80

atg?ctg?aac?aag?gga?cca?cac?atc?aac?gac?gcc?atc?aag?gtc?ctc?acc 288

Met?Leu?Asn?Lys?Gly?Pro?His?Ile?Asn?Asp?Ala?Ile?Lys?Val?Leu?Thr

85 90 95

gaa?atg?agc?cgc?aaa?ctt?ggt?gca?tcc?caa?cga?aag?agt?agg?ctg?ctg 336

Glu?Met?Ser?Arg?Lys?Leu?Gly?Ala?Ser?Gln?Arg?Lys?Ser?Arg?Leu?Leu

100 105 110

ctg?cgc?aag?gtg?aag?agc?tgg?gaa?gag?taactcacaa?aggcgattgg 383

Leu?Arg?Lys?Val?Lys?Ser?Trp?Glu?Glu

115 120

cgt 386

<210>78

<211>121

<212>PRT

＜213〉Corynebacterium glutamicum

<400>78

Ile?Leu?Met?Thr?Gly?Met?Arg?His?Glu?Asn?Phe?Gly?Ile?Met?Ile?Ala

1 5 10 15

Arg?Gly?Asp?Leu?Ala?Val?Glu?Leu?Gly?Phe?Asp?Arg?Met?Ala?Glu?Val

20 25 30

Pro?Gln?Leu?Ile?Met?Ala?Leu?Ala?Glu?Ala?Ala?His?Val?Pro?Thr?Ile

35 40 45

Leu?Ala?Thr?Gln?Val?Leu?Glu?Asn?Met?Ala?Lys?Asn?Gly?Leu?Pro?Ser

50 55 60

Arg?Ala?Glu?Ile?Thr?Asp?Ala?Ala?Met?Ala?Leu?Arg?Ala?Glu?Cys?Val

65 70 75 80

Met?Leu?Asn?Lys?Gly?Pro?His?Ile?Asn?Asp?Ala?Ile?Lys?Val?Leu?Thr

85 90 95

Glu?Met?Ser?Arg?Lys?Leu?Gly?Ala?Ser?Gln?Arg?Lys?Ser?Arg?Leu?Leu

100 105 110

Leu?Arg?Lys?Val?Lys?Ser?Trp?Glu?Glu

115 120

<210>79

<211>1522

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1522)

<223>FRXA02695

<400>79

aagtgtttca?ttggaacact?tgcgctgcca?actttttggt?ttacgggcac?aatgaaactg?60

ttggatggaa?tttagagtgt?ttgtagctta?aggagctcaa?atg?aat?gag?ttt?gac 115

Met?Asn?Glu?Phe?Asp

1 5

cag?gac?att?ctc?cag?gag?atc?aag?act?gaa?ctc?gac?gag?tta?att?cta 163

Gln?Asp?Ile?Leu?Gln?Glu?Ile?Lys?Thr?Glu?Leu?Asp?Glu?Leu?Ile?Leu

10 15 20

gaa?ctt?gat?gag?gtg?aca?caa?act?cac?agc?gag?gcc?atc?ggg?cag?gtc 211

Glu?Leu?Asp?Glu?Val?Thr?Gln?Thr?His?Ser?Glu?Ala?Ile?Gly?Gln?Val

25 30 35

tcc?cca?acc?cat?tac?gtt?ggt?gcc?cgc?aac?ctc?atg?cat?tac?gcg?cat 259

Ser?Pro?Thr?His?Tyr?Val?Gly?Ala?Arg?Asn?Leu?Met?His?Tyr?Ala?His

40 45 50

ctt?cgc?acc?aaa?gac?ctc?cgt?ggc?ctg?cag?caa?cgc?ctc?tcc?tct?gtg 307

Leu?Arg?Thr?Lys?Asp?Leu?Arg?Gly?Leu?Gln?Gln?Arg?Leu?Ser?Ser?Val

55 60 65

gga?gct?acc?cgc?ttg?act?acc?acc?gaa?cca?gca?gtg?cag?gcc?cgc?ctc 355

Gly?Ala?Thr?Arg?Leu?Thr?Thr?Thr?Glu?Pro?Ala?Val?Gln?Ala?Arg?Leu

70 75 80 85

aag?gcc?gcc?cgc?aat?gtt?atc?gga?gct?ttc?gca?ggt?gaa?ggc?cca?ctt 403

Lys?Ala?Ala?Arg?Asn?Val?Ile?Gly?Ala?Phe?Ala?Gly?Glu?Gly?Pro?Leu

90 95 100

tat?cca?ccc?tca?gat?gtc?gtc?gat?gcc?ttc?gaa?gat?gcc?gat?gag?att 451

Tyr?Pro?Pro?Ser?Asp?Val?Val?Asp?Ala?Phe?Glu?Asp?Ala?Asp?Glu?Ile

105 110 115

ctc?gac?gag?cac?gcc?gaa?att?ctc?ctt?ggc?gaa?ccc?cta?ccg?gat?act 499

Leu?Asp?Glu?His?Ala?Glu?Ile?Leu?Leu?Gly?Glu?Pro?Leu?Pro?Asp?Thr

120 125 130

cca?tcc?tgc?atc?atg?gtc?acc?ctg?ccc?acc?gaa?gcc?gcc?acc?gac?att 547

Pro?Ser?Cys?Ile?Met?Val?Thr?Leu?Pro?Thr?Glu?Ala?Ala?Thr?Asp?Ile

135 140 145

gaa?ctt?gtc?cgt?ggc?ttc?gcc?aaa?agc?ggc?atg?aat?cta?gct?cgc?atc 595

Glu?Leu?Val?Arg?Gly?Phe?Ala?Lys?Ser?Gly?Met?Asn?Leu?Ala?Arg?Ile

150 155 160 165

aac?tgt?gca?cac?gac?gat?gaa?acc?gtc?tgg?aag?cag?atg?atc?gac?aac 643

Asn?Cys?Ala?His?Asp?Asp?Glu?Thr?Val?Trp?Lys?Gln?Met?Ile?Asp?Asn

170 175 180

gtc?cac?acc?gtt?gca?gaa?gaa?gtt?ggc?cgg?gaa?atc?cgc?gtc?agc?atg 691

Val?His?Thr?Val?Ala?Glu?Glu?Val?Gly?Arg?Glu?Ile?Arg?Val?Ser?Met

185 190 195

gac?ctc?gcc?gga?cca?aaa?gta?cgc?acc?ggc?gaa?atc?gcc?cca?ggc?gca 739

Asp?Leu?Ala?Gly?Pro?Lys?Val?Arg?Thr?Gly?Glu?Ile?Ala?Pro?Gly?Ala

200 205 210

gaa?gta?ggt?cgc?gca?cga?gta?acc?cgc?gac?gaa?acc?gga?aaa?gta?ctg 787

Glu?Val?Gly?Arg?Ala?Arg?Val?Thr?Arg?Asp?Glu?Thr?Gly?Lys?Val?Leu

215 220 225

acg?ccc?gca?aaa?ctg?tgg?atc?acc?gcc?cac?ggc?tcc?gaa?cca?gtc?cca 835

Thr?Pro?Ala?Lys?Leu?Trp?Ile?Thr?Ala?His?Gly?Ser?Glu?Pro?Val?Pro

230 235 240 245

gcc?ccc?gaa?agc?ctg?ccc?ggt?cgc?ccc?gct?ctg?ccg?att?gaa?gtc?acc 883

Ala?Pro?Glu?Ser?Leu?Pro?Gly?Arg?Pro?Ala?Leu?Pro?Ile?Glu?Val?Thr

250 255 260

cca?gaa?tgg?ttc?gac?aaa?cta?gaa?atc?ggc?agc?gtc?atc?aac?gtc?cca 931

Pro?Glu?Trp?Phe?Asp?Lys?Leu?Glu?Ile?Gly?Ser?Val?Ile?Asn?Val?Pro

265 270 275

gac?acc?cgc?gga?tcc?cgc?cga?gca?ttc?acc?gtg?acc?agg?gtt?ttt?gat 979

Asp?Thr?Arg?Gly?Ser?Arg?Arg?Ala?Phe?Thr?Val?Thr?Arg?Val?Phe?Asp

280 285 290

ggc?gcg?gtc?ctc?gcc?gaa?ggc?cca?caa?aaa?gcc?tac?atc?tcc?aac?ggc 1027

Gly?Ala?Val?Leu?Ala?Glu?Gly?Pro?Gln?Lys?Ala?Tyr?Ile?Ser?Asn?Gly

295 300 305

acc?ctc?ctg?gaa?cac?aac?tac?gac?cgc?tcc?cgg?gtc?tac?ggc?atc?ccc 1075

Thr?Leu?Leu?Glu?His?Asn?Tyr?Asp?Arg?Ser?Arg?Val?Tyr?Gly?Ile?Pro

310 315 320 325

gcc?gta?gtt?cag?cgc?atc?aac?ctc?aaa?gtc?ggc?gac?cgc?ctc?atc?ctt 1123

Ala?Val?Val?Gln?Arg?Ile?Asn?Leu?Lys?Val?Gly?Asp?Arg?Leu?Ile?Leu

330 335 340

acc?gac?gaa?gaa?ctc?acc?tac?gat?cca?tcc?ctc?gga?tcc?ggc?cgc?aca 1171

Thr?Asp?Glu?Glu?Leu?Thr?Tyr?Asp?Pro?Ser?Leu?Gly?Ser?Gly?Arg?Thr

345 350 355

cca?cgc?atc?agc?tgc?acc?ctt?cca?caa?gca?gtc?gat?gca?att?aaa?gtc 1219

Pro?Arg?Ile?Ser?Cys?Thr?Leu?Pro?Gln?Ala?Val?Asp?Ala?Ile?Lys?Val

360 365 370

ggg?cac?cgc?gtg?ctt?ttc?gac?gac?gga?gcc?atc?gcc?gca?gtc?tgc?atc 1267

Gly?His?Arg?Val?Leu?Phe?Asp?Asp?Gly?Ala?Ile?Ala?Ala?Val?Cys?Ile

375 380 385

gac?aag?acc?tcc?act?gcc?gac?ggc?cac?aac?gac?gta?gaa?ttg?gaa?gtc 1315

Asp?Lys?Thr?Ser?Thr?Ala?Asp?Gly?His?Asn?Asp?Val?Glu?Leu?Glu?Val

390 395 400 405

acc?cac?gcc?cgc?cca?caa?ggc?gta?aac?ctg?gcc?gca?tac?aag?gga?atc 1363

Thr?His?Ala?Arg?Pro?Gln?Gly?Val?Asn?Leu?Ala?Ala?Tyr?Lys?Gly?Ile

410 415 420

aac?ctc?cca?gac?tcc?gaa?ctt?cca?ctc?cca?agc?ctc?act?gaa?gaa?gac 1411

Asn?Leu?Pro?Asp?Ser?Glu?Leu?Pro?Leu?Pro?Ser?Leu?Thr?Glu?Glu?Asp

425 430 435

ctc?caa?cac?ctg?cgc?ttt?gtc?gtc?aaa?tac?gcc?gac?atc?gca?gcc?atc 1459

Leu?Gln?His?Leu?Arg?Phe?Val?Val?Lys?Tyr?Ala?Asp?Ile?Ala?Ala?Ile

440 445 450

tcc?ttc?atc?cga?aac?gtc?gcc?gac?gtg?gaa?tac?ctc?ctc?caa?gca?ctc 1507

Ser?Phe?Ile?Arg?Asn?Val?Ala?Asp?Val?Glu?Tyr?Leu?Leu?Gln?Ala?Leu

455 460 465

gcc?gac?atc?gga?gat 1522

Ala?Asp?Ile?Gly?Asp

470

<210>80

<211>474

<212>PRT

＜213〉Corynebacterium glutamicum

<400>80

Met?Asn?Glu?Phe?Asp?Gln?Asp?Ile?Leu?Gln?Glu?Ile?Lys?Thr?Glu?Leu

1 5 10 15

Asp?Glu?Leu?Ile?Leu?Glu?Leu?Asp?Glu?Val?Thr?Gln?Thr?His?Ser?Glu

20 25 30

Ala?Ile?Gly?Gln?Val?Ser?Pro?Thr?His?Tyr?Val?Gly?Ala?Arg?Asn?Leu

35 40 45

Met?His?Tyr?Ala?His?Leu?Arg?Thr?Lys?Asp?Leu?Arg?Gly?Leu?Gln?Gln

50 55 60

Arg?Leu?Ser?Ser?Val?Gly?Ala?Thr?Arg?Leu?Thr?Thr?Thr?Glu?Pro?Ala

65 70 75 80

Val?Gln?Ala?Arg?Leu?Lys?Ala?Ala?Arg?Asn?Val?Ile?Gly?Ala?Phe?Ala

85 90 95

Gly?Glu?Gly?Pro?Leu?Tyr?Pro?Pro?Ser?Asp?Val?Val?Asp?Ala?Phe?Glu

100 105 110

Asp?Ala?Asp?Glu?Ile?Leu?Asp?Glu?His?Ala?Glu?Ile?Leu?Leu?Gly?Glu

115 120 125

Pro?Leu?Pro?Asp?Thr?Pro?Ser?Cys?Ile?Met?Val?Thr?Leu?Pro?Thr?Glu

130 135 140

Ala?Ala?Thr?Asp?Ile?Glu?Leu?Val?Arg?Gly?Phe?Ala?Lys?Ser?Gly?Met

145 150 155 160

Asn?Leu?Ala?Arg?Ile?Asn?Cys?Ala?His?Asp?Asp?Glu?Thr?Val?Trp?Lys

165 170 175

Gln?Met?Ile?Asp?Asn?Val?His?Thr?Val?Ala?Glu?Glu?Val?Gly?Arg?Glu

180 185 190

Ile?Arg?Val?Ser?Met?Asp?Leu?Ala?Gly?Pro?Lys?Val?Arg?Thr?Gly?Glu

195 200 205

Ile?Ala?Pro?Gly?Ala?Glu?Val?Gly?Arg?Ala?Arg?Val?Thr?Arg?Asp?Glu

210 215 220

Thr?Gly?Lys?Val?Leu?Thr?Pro?Ala?Lys?Leu?Trp?Ile?Thr?Ala?His?Gly

225 230 235 240

Ser?Glu?Pro?Val?Pro?Ala?Pro?Glu?Ser?Leu?Pro?Gly?Arg?Pro?Ala?Leu

245 250 255

Pro?Ile?Glu?Val?Thr?Pro?Glu?Trp?Phe?Asp?Lys?Leu?Glu?Ile?Gly?Ser

260 265 270

Val?Ile?Asn?Val?Pro?Asp?Thr?Arg?Gly?Ser?Arg?Arg?Ala?Phe?Thr?Val

275 280 285

Thr?Arg?Val?Phe?Asp?Gly?Ala?Val?Leu?Ala?Glu?Gly?Pro?Gln?Lys?Ala

290 295 300

Tyr?Ile?Ser?Asn?Gly?Thr?Leu?Leu?Glu?His?Asn?Tyr?Asp?Arg?Ser?Arg

305 310 315 320

Val?Tyr?Gly?Ile?Pro?Ala?Val?Val?Gln?Arg?Ile?Asn?Leu?Lys?Val?Gly

325 330 335

Asp?Arg?Leu?Ile?Leu?Thr?Asp?Glu?Glu?Leu?Thr?Tyr?Asp?Pro?Ser?Leu

340 345 350

Gly?Ser?Gly?Arg?Thr?Pro?Arg?Ile?Ser?Cys?Thr?Leu?Pro?Gln?Ala?Val

355 360 365

Asp?Ala?Ile?Lys?Val?Gly?His?Arg?Val?Leu?Phe?Asp?Asp?Gly?Ala?Ile

370 375 380

Ala?Ala?Val?Cys?Ile?Asp?Lys?Thr?Ser?Thr?Ala?Asp?Gly?His?Asn?Asp

385 390 395 400

Val?Glu?Leu?Glu?Val?Thr?His?Ala?Arg?Pro?Gln?Gly?Val?Asn?Leu?Ala

405 410 415

Ala?Tyr?Lys?Gly?Ile?Asn?Leu?Pro?Asp?Ser?Glu?Leu?Pro?Leu?Pro?Ser

420 425 430

Leu?Thr?Glu?Glu?Asp?Leu?Gln?His?Leu?Arg?Phe?Val?Val?Lys?Tyr?Ala

435 440 445

Asp?Ile?Ala?Ala?Ile?Ser?Phe?Ile?Arg?Asn?Val?Ala?Asp?Val?Glu?Tyr

450 455 460

Leu?Leu?Gln?Ala?Leu?Ala?Asp?Ile?Gly?Asp

465 470

<210>81

<211>2022

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1999)

<223>RXA00682

<400>81

ataggcacct?tcgatttcag?ctcaatcacc?gtcgcaatga?ccggcacgaa?gtaaaaccac?60

cgcatctttt?cgtcgaaaag?catctaaaag?gagtttgacc?atg?gct?aat?aaa?tct 115

Met?Ala?Asn?Lys?Ser

1 5

ttc?ccc?aag?ccc?tcc?gat?ctt?cca?gtg?ccc?aag?ggc?gct?gaa?ggt?tgg 163

Phe?Pro?Lys?Pro?Ser?Asp?Leu?Pro?Val?Pro?Lys?Gly?Ala?Glu?Gly?Trp

10 15 20

gaa?gat?ctg?tac?ccg?tac?tac?ctc?gtt?ttc?caa?gac?aag?ctc?atg?gat 211

Glu?Asp?Leu?Tyr?Pro?Tyr?Tyr?Leu?Val?Phe?Gln?Asp?Lys?Leu?Met?Asp

25 30 35

caa?gag?aat?gag?aaa?ttc?tgg?ttc?tgc?gat?tca?cag?cac?tgg?cca?act 259

Gln?Glu?Asn?Glu?Lys?Phe?Trp?Phe?Cys?Asp?Ser?Gln?His?Trp?Pro?Thr

40 45 50

gtg?ttc?aag?cct?ttt?gaa?act?atc?ggt?ggt?gaa?ttc?gct?gta?aag?tgc 307

Val?Phe?Lys?Pro?Phe?Glu?Thr?Ile?Gly?Gly?Glu?Phe?Ala?Val?Lys?Cys

55 60 65

ctc?ggc?caa?tac?aac?gct?cgg?cat?ttg?atg?atc?ccg?aat?gcc?aat?ggc 355

Leu?Gly?Gln?Tyr?Asn?Ala?Arg?His?Leu?Met?Ile?Pro?Asn?Ala?Asn?Gly

70 75 80 85

atc?gag?ttc?cgc?gtg?cat?ctg?gga?tac?ctc?tat?atg?tcc?cct?att?cca 403

Ile?Glu?Phe?Arg?Val?His?Leu?Gly?Tyr?Leu?Tyr?Met?Ser?Pro?Ile?Pro

90 95 100

gtg?cct?gaa?gat?cag?att?gcg?gaa?cgc?gtc?ccc?atg?ttc?cag?gaa?cgc 451

Val?Pro?Glu?Asp?Gln?Ile?Ala?Glu?Arg?Val?Pro?Met?Phe?Gln?Glu?Arg

105 110 115

atc?acg?cac?tac?ttc?caa?aac?tgg?gag?cca?atg?ctg?gca?aat?tgg?aag 499

Ile?Thr?His?Tyr?Phe?Gln?Asn?Trp?Glu?Pro?Met?Leu?Ala?Asn?Trp?Lys

120 125 130

gag?cga?gta?tta?gga?acc?atc?aat?gag?ctg?gaa?tct?cta?gaa?ttc?aag 547

Glu?Arg?Val?Leu?Gly?Thr?Ile?Asn?Glu?Leu?Glu?Ser?Leu?Glu?Phe?Lys

135 140 145

cca?ctg?cct?gac?tac?gtg?cct?atc?gat?gat?att?gtc?tcc?gga?aaa?gcc 595

Pro?Leu?Pro?Asp?Tyr?Val?Pro?Ile?Asp?Asp?Ile?Val?Ser?Gly?Lys?Ala

150 155 160 165

aaa?gac?ggc?acc?gaa?gta?ctc?atg?gaa?aac?ttc?gat?cgg?ctc?att?cag 643

Lys?Asp?Gly?Thr?Glu?Val?Leu?Met?Glu?Asn?Phe?Asp?Arg?Leu?Ile?Gln

170 175 180

ctc?gcc?tac?caa?aac?tgg?caa?tac?cac?ttt?gag?ttc?ctc?aac?ttg?ggt 691

Leu?Ala?Tyr?Gln?Asn?Trp?Gln?Tyr?His?Phe?Glu?Phe?Leu?Asn?Leu?Gly

185 190 195

tac?atc?gct?tac?cta?gat?ttc?ttc?aat?ttc?tgc?aag?gaa?gtc?ttc?cca 739

Tyr?Ile?Ala?Tyr?Leu?Asp?Phe?Phe?Asn?Phe?Cys?Lys?Glu?Val?Phe?Pro

200 205 210

gat?atc?cct?gat?caa?tca?att?tcg?atg?atg?gtt?cag?ggc?gtg?gat?atg 787

Asp?Ile?Pro?Asp?Gln?Ser?Ile?Ser?Met?Met?Val?Gln?Gly?Val?Asp?Met

215 220 225

gag?ctg?ttc?cgc?ccc?gat?gat?gaa?cta?aag?att?ctg?gca?cag?cta?gcg 835

Glu?Leu?Phe?Arg?Pro?Asp?Asp?Glu?Leu?Lys?Ile?Leu?Ala?Gln?Leu?Ala

230 235 240 245

gtc?gac?ctt?ggc?ctg?caa?act?cac?ttt?gcc?aac?ccg?gat?gat?ccg?caa 883

Val?Asp?Leu?Gly?Leu?Gln?Thr?His?Phe?Ala?Asn?Pro?Asp?Asp?Pro?Gln

250 255 260

gct?acc?ttg?gct?gct?atc?gca?aag?gca?gaa?ggc?ggc?gcg?aca?tgg?ata 931

Ala?Thr?Leu?Ala?Ala?Ile?Ala?Lys?Ala?Glu?Gly?Gly?Ala?Thr?Trp?Ile

265 270 275

gcg?cgc?tgg?gaa?gaa?gca?caa?gat?ccg?tgg?ttc?aac?ttc?acc?gtc?ggt 979

Ala?Arg?Trp?Glu?Glu?Ala?Gln?Asp?Pro?Trp?Phe?Asn?Phe?Thr?Val?Gly

280 285 290

aat?ggc?ttc?tac?ggt?cac?gat?aaa?tac?tgg?atc?gag?cac?ctg?gaa?ctt 1027

Asn?Gly?Phe?Tyr?Gly?His?Asp?Lys?Tyr?Trp?Ile?Glu?His?Leu?Glu?Leu

295 300 305

cca?ctg?ggg?tac?atc?gcg?gat?tac?atc?cgc?cgc?cta?gat?gaa?ggc?caa 1075

Pro?Leu?Gly?Tyr?Ile?Ala?Asp?Tyr?Ile?Arg?Arg?Leu?Asp?Glu?Gly?Gln

310 315 320 325

acc?atc?tcc?cgc?ccg?aaa?gat?gaa?ctc?atc?gca?gaa?aag?gaa?cgc?gtg 1123

Thr?Ile?Ser?Arg?Pro?Lys?Asp?Glu?Leu?Ile?Ala?Glu?Lys?Glu?Arg?Val

330 335 340

gtg?gaa?gaa?tac?cgc?gac?ctt?ttg?gat?gga?gaa?caa?ctc?gcg?cag?ttt 1171

Val?Glu?Glu?Tyr?Arg?Asp?Leu?Leu?Asp?Gly?Glu?Gln?Leu?Ala?Gln?Phe

345 350 355

gat?gct?aaa?tgc?ggc?ctc?gct?gct?act?gca?tac?ccc?tat?gtg?gaa?aac 1219

Asp?Ala?Lys?Cys?Gly?Leu?Ala?Ala?Thr?Ala?Tyr?Pro?Tyr?Val?Glu?Asn

360 365 370

cat?aac?ttc?tac?atc?gag?cac?tgg?acc?atg?tca?gta?ttt?tgg?cgc?aaa 1267

His?Asn?Phe?Tyr?Ile?Glu?His?Trp?Thr?Met?Ser?Val?Phe?Trp?Arg?Lys

375 380 385

gta?cgc?gaa?ctt?tcc?cgc?act?ctc?cag?ggc?tac?ggt?ttc?tgg?gag?aac 1315

Val?Arg?Glu?Leu?Ser?Arg?Thr?Leu?Gln?Gly?Tyr?Gly?Phe?Trp?Glu?Asn

390 395 400 405

gag?gat?gac?atg?ttg?tac?ctc?aac?cgc?act?gaa?gtc?cgc?gat?gtc?ctc 1363

Glu?Asp?Asp?Met?Leu?Tyr?Leu?Asn?Arg?Thr?Glu?Val?Arg?Asp?Val?Leu

410 415 420

ttc?gac?ctg?gct?act?gcg?tgg?ggt?gtc?ggc?gca?ccc?ggt?ggt?cca?att 1411

Phe?Asp?Leu?Ala?Thr?Ala?Trp?Gly?Val?Gly?Ala?Pro?Gly?Gly?Pro?Ile

425 430 435

ggc?acg?atc?att?tgg?ccg?gaa?gaa?att?gag?cga?aga?aaa?gca?att?gtc 1459

Gly?Thr?Ile?Ile?Trp?Pro?Glu?Glu?Ile?Glu?Arg?Arg?Lys?Ala?Ile?Val

440 445 450

acc?gct?ttg?aaa?act?gcc?cga?cca?gcg?cca?gct?ctt?aac?act?cct?cca 1507

Thr?Ala?Leu?Lys?Thr?Ala?Arg?Pro?Ala?Pro?Ala?Leu?Asn?Thr?Pro?Pro

455 460 465

gag?tcc?atc?acc?gaa?cct?ttc?acc?cgc?atg?ctc?tgg?gga?atc?acc?acc 1555

Glu?Ser?Ile?Thr?Glu?Pro?Phe?Thr?Arg?Met?Leu?Trp?Gly?Ile?Thr?Thr

470 475 480 485

gaa?cag?gtg?caa?tca?tgg?ttg?ggc?aat?gac?gag?gat?gcc?gaa?gaa?gga 1603

Glu?Gln?Val?Gln?Ser?Trp?Leu?Gly?Asn?Asp?Glu?Asp?Ala?Glu?Glu?Gly

490 495 500

acc?ctt?aaa?ggc?atg?gct?gca?tcc?cct?ggt?gtg?gtg?gaa?ggc?tac?gct 1651

Thr?Leu?Lys?Gly?Met?Ala?Ala?Ser?Pro?Gly?Val?Val?Glu?Gly?Tyr?Ala

505 510 515

cga?gta?att?ctc?agc?gca?gat?gac?ctt?tca?gaa?atc?cag?cag?gat?gaa 1699

Arg?Val?Ile?Leu?Ser?Ala?Asp?Asp?Leu?Ser?Glu?Ile?Gln?Gln?Asp?Glu

520 525 530

atc?ctc?gtt?gcc?cct?gta?aca?gca?cct?tct?tgg?ggc?cca?atc?ttt?ggc 1747

Ile?Leu?Val?Ala?Pro?Val?Thr?Ala?Pro?Ser?Trp?Gly?Pro?Ile?Phe?Gly

535 540 545

aaa?atc?aag?gca?aca?gtc?act?gat?att?ggt?ggc?atg?atg?agc?cat?gct 1795

Lys?Ile?Lys?Ala?Thr?Val?Thr?Asp?Ile?Gly?Gly?Met?Met?Ser?His?Ala

550 555 560 565

gcg?atc?gtg?tgc?cgc?gaa?tac?ggc?ttg?ccg?gct?gtt?act?gga?act?ggc 1843

Ala?Ile?Val?Cys?Arg?Glu?Tyr?Gly?Leu?Pro?Ala?Val?Thr?Gly?Thr?Gly

570 575 580

gct?gca?tcc?acc?acc?atc?aaa?acc?ggc?gat?tac?ctc?aag?gtc?gat?gga 1891

Ala?Ala?Ser?Thr?Thr?Ile?Lys?Thr?Gly?Asp?Tyr?Leu?Lys?Val?Asp?Gly

585 590 595

acc?aag?ggc?aag?gtt?gtc?att?gtt?gat?cca?gat?gcg?cca?cgc?atc?gaa 1939

Thr?Lys?Gly?Lys?Val?Val?Ile?Val?Asp?Pro?Asp?Ala?Pro?Arg?Ile?Glu

600 605 610

gga?ccc?ggc?gcg?cac?agc?cat?gcg?cac?tca?gta?gca?gca?cat?ggg?gtg 1987

Gly?Pro?Gly?Ala?His?Ser?His?Ala?His?Ser?Val?Ala?Ala?His?Gly?Val

615 620 625

gat?aca?cat?gcc?tagtccacgc?actgttctta?tca 2022

Asp?Thr?His?Ala

630

<210>82

<211>633

<212>PRT

＜213〉Corynebacterium glutamicum

<400>82

Met?Ala?Asn?Lys?Ser?Phe?Pro?Lys?Pro?Ser?Asp?Leu?Pro?Val?Pro?Lys

1 5 10 15

Gly?Ala?Glu?Gly?Trp?Glu?Asp?Leu?Tyr?Pro?Tyr?Tyr?Leu?Val?Phe?Gln

20 25 30

Asp?Lys?Leu?Met?Asp?Gln?Glu?Asn?Glu?Lys?Phe?Trp?Phe?Cys?Asp?Ser

35 40 45

Gln?His?Trp?Pro?Thr?Val?Phe?Lys?Pro?Phe?Glu?Thr?Ile?Gly?Gly?Glu

50 55 60

Phe?Ala?Val?Lys?Cys?Leu?Gly?Gln?Tyr?Asn?Ala?Arg?His?Leu?Met?Ile

65 70 75 80

Pro?Asn?Ala?Asn?Gly?Ile?Glu?Phe?Arg?Val?His?Leu?Gly?Tyr?Leu?Tyr

85 90 95

Met?Ser?Pro?Ile?Pro?Val?Pro?Glu?Asp?Gln?Ile?Ala?Glu?Arg?Val?Pro

100 105 110

Met?Phe?Gln?Glu?Arg?Ile?Thr?His?Tyr?Phe?Gln?Asn?Trp?Glu?Pro?Met

115 120 125

Leu?Ala?Asn?Trp?Lys?Glu?Arg?Val?Leu?Gly?Thr?Ile?Asn?Glu?Leu?Glu

130 135 140

Ser?Leu?Glu?Phe?Lys?Pro?Leu?Pro?Asp?Tyr?Val?Pro?Ile?Asp?Asp?Ile

145 150 155 160

Val?Ser?Gly?Lys?Ala?Lys?Asp?Gly?Thr?Glu?Val?Leu?Met?Glu?Asn?Phe

165 170 175

Asp?Arg?Leu?Ile?Gln?Leu?Ala?Tyr?Gln?Asn?Trp?Gln?Tyr?His?Phe?Glu

180 185 190

Phe?Leu?Asn?Leu?Gly?Tyr?Ile?Ala?Tyr?Leu?Asp?Phe?Phe?Asn?Phe?Cys

195 200 205

Lys?Glu?Val?Phe?Pro?Asp?Ile?Pro?Asp?Gln?Ser?Ile?Ser?Met?Met?Val

210 215 220

Gln?Gly?Val?Asp?Met?Glu?Leu?Phe?Arg?Pro?Asp?Asp?Glu?Leu?Lys?Ile

225 230 235 240

Leu?Ala?Gln?Leu?Ala?Val?Asp?Leu?Gly?Leu?Gln?Thr?His?Phe?Ala?Asn

245 250 255

Pro?Asp?Asp?Pro?Gln?Ala?Thr?Leu?Ala?Ala?Ile?Ala?Lys?Ala?Glu?Gly

260 265 270

Gly?Ala?Thr?Trp?Ile?Ala?Arg?Trp?Glu?Glu?Ala?Gln?Asp?Pro?Trp?Phe

275 280 285

Asn?Phe?Thr?Val?Gly?Asn?Gly?Phe?Tyr?Gly?His?Asp?Lys?Tyr?Trp?Ile

290 295 300

Glu?His?Leu?Glu?Leu?Pro?Leu?Gly?Tyr?Ile?Ala?Asp?Tyr?Ile?Arg?Arg

305 310 315 320

Leu?Asp?Glu?Gly?Gln?Thr?Ile?Ser?Arg?Pro?Lys?Asp?Glu?Leu?Ile?Ala

325 330 335

Glu?Lys?Glu?Arg?Val?Val?Glu?Glu?Tyr?Arg?Asp?Leu?Leu?Asp?Gly?Glu

340 345 350

Gln?Leu?Ala?Gln?Phe?Asp?Ala?Lys?Cys?Gly?Leu?Ala?Ala?Thr?Ala?Tyr

355 360 365

Pro?Tyr?Val?Glu?Asn?His?Asn?Phe?Tyr?Ile?Glu?His?Trp?Thr?Met?Ser

370 375 380

Val?Phe?Trp?Arg?Lys?Val?Arg?Glu?Leu?Ser?Arg?Thr?Leu?Gln?Gly?Tyr

385 390 395 400

Gly?Phe?Trp?Glu?Asn?Glu?Asp?Asp?Met?Leu?Tyr?Leu?Asn?Arg?Thr?Glu

405 410 415

Val?Arg?Asp?Val?Leu?Phe?Asp?Leu?Ala?Thr?Ala?Trp?Gly?Val?Gly?Ala

420 425 430

Pro?Gly?Gly?Pro?Ile?Gly?Thr?Ile?Ile?Trp?Pro?Glu?Glu?Ile?Glu?Arg

435 440 445

Arg?Lys?Ala?Ile?Val?Thr?Ala?Leu?Lys?Thr?Ala?Arg?Pro?Ala?Pro?Ala

450 455 460

Leu?Asn?Thr?Pro?Pro?Glu?Ser?Ile?Thr?Glu?Pro?Phe?Thr?Arg?Met?Leu

465 470 475 480

Trp?Gly?Ile?Thr?Thr?Glu?Gln?Val?Gln?Ser?Trp?Leu?Gly?Asn?Asp?Glu

485 490 495

Asp?Ala?Glu?Glu?Gly?Thr?Leu?Lys?Gly?Met?Ala?Ala?Ser?Pro?Gly?Val

500 505 510

Val?Glu?Gly?Tyr?Ala?Arg?Val?Ile?Leu?Ser?Ala?Asp?Asp?Leu?Ser?Glu

515 520 525

Ile?Gln?Gln?Asp?Glu?Ile?Leu?Val?Ala?Pro?Val?Thr?Ala?Pro?Ser?Trp

530 535 540

Gly?Pro?Ile?Phe?Gly?Lys?Ile?Lys?Ala?Thr?Val?Thr?Asp?Ile?Gly?Gly

545 550 555 560

Met?Met?Ser?His?Ala?Ala?Ile?Val?Cys?Arg?Glu?Tyr?Gly?Leu?Pro?Ala

565 570 575

Val?Thr?Gly?Thr?Gly?Ala?Ala?Ser?Thr?Thr?Ile?Lys?Thr?Gly?Asp?Tyr

580 585 590

Leu?Lys?Val?Asp?Gly?Thr?Lys?Gly?Lys?Val?Val?Ile?Val?Asp?Pro?Asp

595 600 605

Ala?Pro?Arg?Ile?Glu?Gly?Pro?Gly?Ala?His?Ser?His?Ala?His?Ser?Val

610 615 620

Ala?Ala?His?Gly?Val?Asp?Thr?His?Ala

625 630

<210>83

<211>1215

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1192)

<223>RXA00683

<400>83

ggacaaagct?atcgggttcc?gggagaacct?ctccttccgc?gtccccactt?ctgttcccgt?60

gacttggaac?gcttaacgct?ttattaaata?aggagacacc?atg?acc?aac?agt?ttg 115

Met?Thr?Asn?Ser?Leu

1 5

aac?atc?ccg?ttt?gtc?cag?cgc?ttc?gat?gaa?ggc?ctg?gat?cct?gtt?cta 163

Asn?Ile?Pro?Phe?Val?Gln?Arg?Phe?Asp?Glu?Gly?Leu?Asp?Pro?Val?Leu

10 15 20

gaa?gta?ctc?ggt?ggc?aag?ggc?gct?tca?cta?gtc?acc?atg?aca?gat?gct 211

Glu?Val?Leu?Gly?Gly?Lys?Gly?Ala?Ser?Leu?Val?Thr?Met?Thr?Asp?Ala

25 30 35

gga?atg?ccc?gtt?cca?cct?gga?ttt?gtg?gtc?act?act?gcc?agc?ttt?gat 259

Gly?Met?Pro?Val?Pro?Pro?Gly?Phe?Val?Val?Thr?Thr?Ala?Ser?Phe?Asp

40 45 50

gaa?ttc?atc?cgt?gaa?gca?ggg?gtt?gct?gaa?cac?atc?gat?aaa?ttc?cta 307

Glu?Phe?Ile?Arg?Glu?Ala?Gly?Val?Ala?Glu?His?Ile?Asp?Lys?Phe?Leu

55 60 65

aac?gat?ctc?gat?gca?gaa?gat?gtt?aag?gaa?gtg?gat?cga?gtt?tct?gcg 355

Asn?Asp?Leu?Asp?Ala?Glu?Asp?Val?Lys?Glu?Val?Asp?Arg?Val?Ser?Ala

70 75 80 85

atc?atc?cgc?gat?gag?ctg?tgc?agt?ctt?gac?gtt?cca?gag?aat?gct?cgt 403

Ile?Ile?Arg?Asp?Glu?Leu?Cys?Ser?Leu?Asp?Val?Pro?Glu?Asn?Ala?Arg

90 95 100

ttc?gca?gtg?cac?cag?gct?tat?cgc?gat?ctc?atg?gaa?cga?tgc?ggt?ggc 451

Phe?Ala?Val?His?Gln?Ala?Tyr?Arg?Asp?Leu?Met?Glu?Arg?Cys?Gly?Gly

105 110 115

gac?gtc?ccg?gtt?gct?gtc?cgg?tca?tcg?gcc?act?gcc?gaa?gat?ctg?ccc 499

Asp?Val?Pro?Val?Ala?Val?Arg?Ser?Ser?Ala?Thr?Ala?Glu?Asp?Leu?Pro

120 125 130

gat?gct?tcc?ttc?gca?ggg?caa?cag?gac?acc?tat?ctg?tgg?caa?gtc?ggt 547

Asp?Ala?Ser?Phe?Ala?Gly?Gln?Gln?Asp?Thr?Tyr?Leu?Trp?Gln?Val?Gly

135 140 145

ttg?agc?gct?gtc?act?gaa?cac?atc?cgt?aaa?tgc?tgg?gct?tcg?ctg?ttc 595

Leu?Ser?Ala?Val?Thr?Glu?His?Ile?Arg?Lys?Cys?Trp?Ala?Ser?Leu?Phe

150 155 160 165

act?tcc?cgt?gcc?att?atc?tac?cgt?ctg?aaa?aac?aac?atc?ccc?aat?gag 643

Thr?Ser?Arg?Ala?Ile?Ile?Tyr?Arg?Leu?Lys?Asn?Asn?Ile?Pro?Asn?Glu

170 175 180

ggc?ctc?tcc?atg?gcg?gta?gtt?gtt?caa?aaa?atg?gtc?aac?tct?cgt?gtc 691

Gly?Leu?Ser?Met?Ala?Val?Val?Val?Gln?Lys?Met?Val?Asn?Ser?Arg?Val

185 190 195

gca?ggc?gtg?gca?atc?act?atg?aat?cct?tcc?aac?ggc?gac?cgc?tcg?aag 739

Ala?Gly?Val?Ala?Ile?Thr?Met?Asn?Pro?Ser?Asn?Gly?Asp?Arg?Ser?Lys

200 205 210

atc?acc?atc?gat?tcc?tca?tgg?ggt?gtt?ggt?gaa?atg?gtg?gtc?tca?ggt 787

Ile?Thr?Ile?Asp?Ser?Ser?Trp?Gly?Val?Gly?Glu?Met?Val?Val?Ser?Gly

215 220 225

gaa?gtg?aca?cca?gac?aat?atc?ttg?ctg?gac?aag?atc?acg?ctg?cag?gtt 835

Glu?Val?Thr?Pro?Asp?Asn?Ile?Leu?Leu?Asp?Lys?Ile?Thr?Leu?Gln?Val

230 235 240 245

gtc?tcc?gaa?cac?att?gga?agc?aaa?cac?gct?gaa?ctc?atc?ccc?gat?gcc 883

Val?Ser?Glu?His?Ile?Gly?Ser?Lys?His?Ala?Glu?Leu?Ile?Pro?Asp?Ala

250 255 260

acc?agt?gga?agc?ctc?gtg?gaa?aag?ccc?gtt?gat?gaa?gaa?cgc?gca?aac 931

Thr?Ser?Gly?Ser?Leu?Val?Glu?Lys?Pro?Val?Asp?Glu?Glu?Arg?Ala?Asn

265 270 275

cgc?cgc?agt?ctg?act?gat?gag?gaa?atg?ctc?gct?gtg?gca?caa?atg?gct 979

Arg?Arg?Ser?Leu?Thr?Asp?Glu?Glu?Met?Leu?Ala?Val?Ala?Gln?Met?Ala

280 285 290

aag?cgt?gca?gaa?aaa?cac?tac?aag?tgc?cca?caa?gat?atc?gaa?tgg?gcg 1027

Lys?Arg?Ala?Glu?Lys?His?Tyr?Lys?Cys?Pro?Gln?Asp?Ile?Glu?Trp?Ala

295 300 305

ctg?gac?gct?gat?ctg?cca?gat?gga?gaa?aac?ctt?ctg?tta?ttg?caa?tcc 1075

Leu?Asp?Ala?Asp?Leu?Pro?Asp?Gly?Glu?Asn?Leu?Leu?Leu?Leu?Gln?Ser

310 315 320 325

cgc?ccg?gaa?act?atc?cac?tcc?aac?ggt?gtg?aag?aag?gaa?acc?cca?act 1123

Arg?Pro?Glu?Thr?Ile?His?Ser?Asn?Gly?Val?Lys?Lys?Glu?Thr?Pro?Thr

330 335 340

ccg?cag?gct?gcc?aaa?acc?ata?ggc?acc?ttc?gat?ttc?agc?tca?atc?acc 1171

Pro?Gln?Ala?Ala?Lys?Thr?Ile?Gly?Thr?Phe?Asp?Phe?Ser?Ser?Ile?Thr

345 350 355

gtc?gca?atg?acc?ggc?acg?aag?taaaaccacc?gcatcttttc?gtc 1215

Val?Ala?Met?Thr?Gly?Thr?Lys

360

<210>84

<211>364

<212>PRT

＜213〉Corynebacterium glutamicum

<400>84

Met?Thr?Asn?Ser?Leu?Asn?Ile?Pro?Phe?Val?Gln?Arg?Phe?Asp?Glu?Gly

1 5 10 15

Leu?Asp?Pro?Val?Leu?Glu?Val?Leu?Gly?Gly?Lys?Gly?Ala?Ser?Leu?Val

20 25 30

Thr?Met?Thr?Asp?Ala?Gly?Met?Pro?Val?Pro?Pro?Gly?Phe?Val?Val?Thr

35 40 45

Thr?Ala?Ser?Phe?Asp?Glu?Phe?Ile?Arg?Glu?Ala?Gly?Val?Ala?Glu?His

50 55 60

Ile?Asp?Lys?Phe?Leu?Asn?Asp?Leu?Asp?Ala?Glu?Asp?Val?Lys?Glu?Val

65 70 75 80

Asp?Arg?Val?Ser?Ala?Ile?Ile?Arg?Asp?Glu?Leu?Cys?Ser?Leu?Asp?Val

85 90 95

Pro?Glu?Asn?Ala?Arg?Phe?Ala?Val?His?Gln?Ala?Tyr?Arg?Asp?Leu?Met

100 105 110

Glu?Arg?Cys?Gly?Gly?Asp?Val?Pro?Val?Ala?ValArg?Ser?Ser?Ala?Thr

115 120 125

Ala?Glu?Asp?Leu?Pro?Asp?Ala?Ser?Phe?Ala?Gly?Gln?Gln?Asp?Thr?Tyr

130 135 140

Leu?Trp?Gln?Val?Gly?Leu?Ser?Ala?Val?Thr?Glu?His?Ile?Arg?Lys?Cys

145 150 155 160

Trp?Ala?Ser?Leu?Phe?Thr?Ser?Arg?Ala?Ile?Ile?Tyr?Arg?Leu?Lys?Asn

165 170 175

Asn?Ile?Pro?Asn?Glu?Gly?Leu?Ser?Met?Ala?Val?Val?Val?Gln?Lys?Met

180 185 190

Val?Asn?Ser?Arg?Val?Ala?Gly?Val?Ala?Ile?Thr?Met?Asn?Pro?Ser?Asn

195 200 205

Gly?Asp?Arg?Ser?Lys?Ile?Thr?Ile?Asp?Ser?Ser?Trp?Gly?Val?Gly?Glu

210 215 220

Met?Val?Val?Ser?Gly?Glu?Val?Thr?Pro?Asp?Asn?Ile?Leu?Leu?Asp?Lys

225 230 235 240

Ile?Thr?Leu?Gln?Val?Val?Ser?Glu?His?Ile?Gly?Ser?Lys?His?Ala?Glu

245 250 255

Leu?Ile?Pro?Asp?Ala?Thr?Ser?Gly?Ser?Leu?Val?Glu?Lys?Pro?Val?Asp

260 265 270

Glu?Glu?Arg?Ala?Asn?Arg?Arg?Ser?Leu?Thr?Asp?Glu?Glu?Met?Leu?Ala

275 280 285

Val?Ala?Gln?Met?Ala?Lys?Arg?Ala?Glu?Lys?His?Tyr?Lys?Cys?Pro?Gln

290 295 300

Asp?Ile?Glu?Trp?Ala?Leu?Asp?Ala?Asp?Leu?Pro?Asp?Gly?Glu?Asn?Leu

305 310 315 320

Leu?Leu?Leu?Gln?Ser?Arg?Pro?Glu?Thr?Ile?His?Ser?Asn?Gly?Val?Lys

325 330 335

Lys?Glu?Thr?Pro?Thr?Pro?Gln?Ala?Ala?Lys?Thr?Ile?Gly?Thr?Phe?Asp

340 345 350

Phe?Ser?Ser?Ile?Thr?Val?Ala?Met?Thr?Gly?Thr?Lys

355 360

<210>85

<211>1860

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1837)

<223>RXN00635

<400>85

ctggcaggcg?ggcgaagcgt?ggcaacaact?ggaatttaag?agcacaattg?aagtcgcacc?60

aagttaggca?acacaatagc?cataacgttg?aggagttcag?atg?gca?cac?agc?tac 115

Met?Ala?His?Ser?Tyr

1 5

gca?gaa?caa?tta?att?gac?act?ttg?gaa?gct?caa?ggt?gtg?aag?cga?att 163

Ala?Glu?Gln?Leu?Ile?Asp?Thr?Leu?Glu?Ala?Gln?Gly?Val?Lys?Arg?Ile

10 15 20

tat?ggt?ttg?gtg?ggt?gac?agc?ctt?aat?ccg?atc?gtg?gat?gct?gtc?cgc 211

Tyr?Gly?Leu?Val?Gly?Asp?Ser?Leu?Asn?Pro?Ile?Val?Asp?Ala?Val?Arg

25 30 35

caa?tca?gat?att?gag?tgg?gtg?cac?gtt?cga?aat?gag?gaa?gcg?gcg?gcg 259

Gln?Ser?Asp?Ile?Glu?Trp?Val?His?Val?Arg?Asn?Glu?Glu?Ala?Ala?Ala

40 45 50

ttt?gca?gcc?ggt?gcg?gaa?tcg?ttg?atc?act?ggg?gag?ctg?gca?gta?tgt 307

Phe?Ala?Ala?Gly?Ala?Glu?Ser?Leu?Ile?Thr?Gly?Glu?Leu?Ala?Val?Cys

55 60 65

gct?gct?tct?tgt?ggt?cct?gga?aac?aca?cac?ctg?att?cag?ggt?ctt?tat 355

Ala?Ala?Ser?Cys?Gly?Pro?Gly?Asn?Thr?His?Leu?Ile?Gln?Gly?Leu?Tyr

70 75 80 85

gat?tcg?cat?cga?aat?ggt?gcg?aag?gtg?ttg?gcc?atc?gct?agc?cat?att 403

Asp?Ser?His?Arg?Asn?Gly?Ala?Lys?Val?Leu?Ala?Ile?Ala?Ser?His?Ile

90 95 100

ccg?agt?gcc?cag?att?ggt?tcg?acg?ttc?ttc?cag?gaa?acg?cat?ccg?gag 451

Pro?Ser?Ala?Gln?Ile?Gly?Ser?Thr?Phe?Phe?Gln?Glu?Thr?His?Pro?Glu

105 110 115

att?ttg?ttt?aag?gaa?tgc?tct?ggt?tac?tgc?gag?atg?gtg?aat?ggt?ggt 499

Ile?Leu?Phe?Lys?Glu?Cys?Ser?Gly?Tyr?Cys?Glu?Met?Val?Asn?Gly?Gly

120 125 130

gag?cag?ggt?gaa?cgc?att?ttg?cat?cac?gcg?att?cag?tcc?acc?atg?gcg 547

Glu?Gln?Gly?Glu?Arg?Ile?Leu?His?His?Ala?Ile?Gln?Ser?Thr?Met?Ala

135 140 145

ggt?aaa?ggt?gtg?tcg?gtg?gta?gtg?att?cct?ggt?gat?atc?gct?aag?gaa 595

Gly?Lys?Gly?Val?Ser?Val?Val?Val?Ile?Pro?Gly?Asp?Ile?Ala?Lys?Glu

150 155 160 165

gac?gca?ggt?gac?ggt?act?tat?tcc?aat?tcc?act?att?tct?tct?ggc?act 643

Asp?Ala?Gly?Asp?Gly?Thr?Tyr?Ser?Asn?Ser?Thr?Ile?Ser?Ser?Gly?Thr

170 175 180

cct?gtg?gtg?ttc?ccg?gat?cct?act?gag?gct?gca?gcg?ctg?gtg?gag?gcg 691

Pro?Val?Val?Phe?Pro?Asp?Pro?Thr?Glu?Ala?Ala?Ala?Leu?Val?Glu?Ala

185 190 195

att?aac?aac?gct?aag?tct?gtc?act?ttg?ttc?tgc?ggt?gcg?ggc?gtg?aag 739

Ile?Asn?Asn?Ala?Lys?Ser?Val?Thr?Leu?Phe?Cys?Gly?Ala?Gly?Val?Lys

200 205 210

aat?gct?cgc?gcg?cag?gtg?ttg?gag?ttg?gcg?gag?aag?att?aaa?tca?ccg 787

Asn?Ala?Arg?Ala?Gln?Val?Leu?Glu?Leu?Ala?Glu?Lys?Ile?Lys?Ser?Pro

215 220 225

atc?ggg?cat?gcg?ctg?ggt?ggt?aag?cag?tac?atc?cag?cat?gag?aat?ccg 835

Ile?Gly?His?Ala?Leu?Gly?Gly?Lys?Gln?Tyr?Ile?Gln?His?Glu?Asn?Pro

230 235 240 245

ttt?gag?gtc?ggc?atg?tct?ggc?ctg?ctt?ggt?tac?ggc?gcc?tgc?gtg?gat 883

Phe?Glu?Val?Gly?Met?Ser?Gly?Leu?Leu?Gly?Tyr?Gly?Ala?Cys?Val?Asp

250 255 260

gcg?tcc?aat?gag?gcg?gat?ctg?ctg?att?cta?ttg?ggt?acg?gat?ttc?cct 931

Ala?Ser?Asn?Glu?Ala?Asp?Leu?Leu?Ile?Leu?Leu?Gly?Thr?Asp?Phe?Pro

265 270 275

tat?tct?gat?ttc?ctt?cct?aaa?gac?aac?gtt?gcc?cag?gtg?gat?atc?aac 979

Tyr?Ser?Asp?Phe?Leu?Pro?Lys?Asp?Asn?Val?Ala?Gln?Val?Asp?Ile?Asn

280 285 290

ggt?gcg?cac?att?ggt?cga?cgt?acc?acg?gtg?aag?tat?ccg?gtg?acc?ggt 1027

Gly?Ala?His?Ile?Gly?Arg?Arg?Thr?Thr?Val?Lys?Tyr?Pro?Val?Thr?Gly

295 300 305

gat?gtt?gct?gca?aca?atc?gaa?aat?att?ttg?cct?cat?gtg?aag?gaa?aaa 1075

Asp?Val?Ala?Ala?Thr?Ile?Glu?Asn?Ile?Leu?Pro?His?Val?Lys?Glu?Lys

310 315 320 325

aca?gat?cgt?tcc?ttc?ctt?gat?cgg?atg?ctc?aag?gca?cac?gag?cgt?aag 1123

Thr?Asp?Arg?Ser?Phe?Leu?Asp?Arg?Met?Leu?Lys?Ala?His?Glu?Arg?Lys

330 335 340

ttg?agc?tcg?gtg?gta?gag?acg?tac?aca?cat?aac?gtc?gag?aag?cat?gtg 1171

Leu?Ser?Ser?Val?Val?Glu?Thr?Tyr?Thr?His?Asn?Val?Glu?Lys?His?Val

345 350 355

cct?att?cac?cct?gaa?tac?gtt?gcc?tct?att?ttg?aac?gag?ctg?gcg?gat 1219

Pro?Ile?His?Pro?Glu?Tyr?Val?Ala?Ser?Ile?Leu?Asn?Glu?Leu?Ala?Asp

360 365 370

aag?gat?gcg?gtg?ttt?act?gtg?gat?acc?ggc?atg?tgc?aat?gtg?tgg?cat 1267

Lys?Asp?Ala?Val?Phe?Thr?Val?Asp?Thr?Gly?Met?Cys?Asn?Val?Trp?His

375 380 385

gcg?agg?tac?atc?gag?aat?ccg?gag?gga?acg?cgc?gac?ttt?gtg?ggt?tca 1315

Ala?Arg?Tyr?Ile?Glu?Asn?Pro?Glu?Gly?Thr?Arg?Asp?Phe?Val?Gly?Ser

390 395 400 405

ttc?cgc?cac?ggc?acg?atg?gct?aat?gcg?ttg?cct?cat?gcg?att?ggt?gcg 1363

Phe?Arg?His?Gly?Thr?Met?Ala?Asn?Ala?Leu?Pro?His?Ala?Ile?Gly?Ala

410 415 420

caa?agt?gtt?gat?cga?aac?cgc?cag?gtg?atc?gcg?atg?tgt?ggc?gat?ggt 1411

Gln?Ser?Val?Asp?Arg?Asn?Arg?Gln?Val?Ile?Ala?Met?Cys?Gly?Asp?Gly

425 430 435

ggt?ttg?ggc?atg?ctg?ctg?ggt?gag?ctt?ctg?acc?gtt?aag?ctg?cac?caa 1459

Gly?Leu?Gly?Met?Leu?Leu?Gly?Glu?Leu?Leu?Thr?Val?Lys?Leu?His?Gln

440 445 450

ctt?ccg?ctg?aag?gct?gtg?gtg?ttt?aac?aac?agt?tct?ttg?ggc?atg?gtg 1507

Leu?Pro?Leu?Lys?Ala?Val?Val?Phe?Asn?Asn?Ser?Ser?Leu?Gly?Met?Val

455 460 465

aag?ttg?gag?atg?ctc?gtg?gag?gga?cag?cca?gaa?ttt?ggt?act?gac?cat 1555

Lys?Leu?Glu?Met?Leu?Val?Glu?Gly?Gln?Pro?Glu?Phe?Gly?Thr?Asp?His

470 475 480 485

gag?gaa?gtg?aat?ttc?gca?gag?att?gcg?gcg?gct?gcg?ggt?atc?aaa?tcg 1603

Glu?Glu?Val?Asn?Phe?Ala?Glu?Ile?Ala?Ala?Ala?Ala?Gly?Ile?Lys?Ser

490 495 500

gta?cgc?atc?acc?gat?ccg?aag?aaa?gtt?cgc?gag?cag?cta?gct?gag?gca 1651

Val?Arg?Ile?Thr?Asp?Pro?Lys?Lys?Val?Arg?Glu?Gln?Leu?Ala?Glu?Ala

505 510 515

ttg?gca?tat?cct?gga?cct?gta?ctg?atc?gat?atc?gtc?acg?gat?cct?aat 1699

Leu?Ala?Tyr?Pro?Gly?Pro?Val?Leu?Ile?Asp?Ile?Val?Thr?Asp?Pro?Asn

520 525 530

gcg?ctg?tcg?atc?cca?cca?acc?atc?acg?tgg?gaa?cag?gtc?atg?gga?ttc 1747

Ala?Leu?Ser?Ile?Pro?Pro?Thr?Ile?Thr?Trp?Glu?Gln?Val?Met?Gly?Phe

535 540 545

agc?aag?gcg?gcc?acc?cga?acc?gtc?ttt?ggt?gga?gga?gta?gga?gcg?atg 1795

Ser?Lys?Ala?Ala?Thr?Arg?Thr?Val?Phe?Gly?Gly?Gly?Val?Gly?Ala?Met

550 555 560 565

atc?gat?ctg?gcc?cgt?tcg?aac?ata?agg?aat?att?cct?act?cca 1837

Ile?Asp?Leu?Ala?Arg?Ser?Asn?Ile?Arg?Asn?Ile?Pro?Thr?Pro

570 575

tgatgattga?tacacctgct?gtt 1860

<210>86

<211>579

<212>PRT

＜213〉Corynebacterium glutamicum

<400>86

Met?Ala?His?Ser?Tyr?Ala?Glu?Gln?Leu?Ile?Asp?Thr?Leu?Glu?Ala?Gln

1 5 10 15

Gly?Val?Lys?Arg?Ile?Tyr?Gly?Leu?Val?Gly?Asp?Ser?Leu?Asn?Pro?Ile

20 25 30

Val?Asp?Ala?Val?Arg?Gln?Ser?Asp?Ile?Glu?Trp?Val?His?Val?Arg?Asn

35 40 45

Glu?Glu?Ala?Ala?Ala?Phe?Ala?Ala?Gly?Ala?Glu?Ser?Leu?Ile?Thr?Gly

50 55 60

Glu?Leu?Ala?Val?Cys?Ala?Ala?Ser?Cys?Gly?Pro?Gly?Asn?Thr?His?Leu

65 70 75 80

Ile?Gln?Gly?Leu?Tyr?Asp?Ser?His?Arg?Asn?Gly?Ala?Lys?Val?Leu?Ala

85 90 95

Ile?Ala?Ser?His?Ile?Pro?Ser?Ala?Gln?Ile?Gly?Ser?Thr?Phe?Phe?Gln

100 105 110

Glu?Thr?His?Pro?Glu?Ile?Leu?Phe?Lys?Glu?Cys?Ser?Gly?Tyr?Cys?Glu

115 120 125

Met?Val?Asn?Gly?Gly?Glu?Gln?Gly?Glu?Arg?Ile?Leu?His?His?Ala?Ile

130 135 140

Gln?Ser?Thr?Met?Ala?Gly?Lys?Gly?Val?Ser?Val?Val?Val?Ile?Pro?Gly

145 150 155 160

Asp?Ile?Ala?Lys?Glu?Asp?Ala?Gly?Asp?Gly?Thr?Tyr?Ser?Asn?Ser?Thr

165 170 175

Ile?Ser?Ser?Gly?Thr?Pro?Val?Val?Phe?Pro?Asp?Pro?Thr?Glu?Ala?Ala

180 185 190

Ala?Leu?Val?Glu?Ala?Ile?Asn?Asn?Ala?Lys?Ser?Val?Thr?Leu?Phe?Cys

195 200 205

Gly?Ala?Gly?Val?Lys?Asn?Ala?Arg?Ala?Gln?Val?Leu?Glu?Leu?Ala?Glu

210 215 220

Lys?Ile?Lys?Ser?Pro?Ile?Gly?His?Ala?Leu?Gly?Gly?Lys?Gln?Tyr?Ile

225 230 235 240

Gln?His?Glu?Asn?Pro?Phe?Glu?Val?Gly?Met?Ser?Gly?Leu?Leu?Gly?Tyr

245 250 255

Gly?Ala?Cys?Val?Asp?Ala?Ser?Asn?Glu?Ala?Asp?Leu?Leu?Ile?Leu?Leu

260 265 270

Gly?Thr?Asp?Phe?Pro?Tyr?Ser?Asp?Phe?Leu?Pro?Lys?Asp?Asn?Val?Ala

275 280 285

Gln?Val?Asp?Ile?Asn?Gly?Ala?His?Ile?Gly?Arg?Arg?Thr?Thr?Val?Lys

290 295 300

Tyr?Pro?Val?Thr?Gly?Asp?Val?Ala?Ala?Thr?Ile?Glu?Asn?Ile?Leu?Pro

305 310 315 320

His?Val?Lys?Glu?Lys?Thr?Asp?Arg?Ser?Phe?Leu?Asp?Arg?Met?Leu?Lys

325 330 335

Ala?His?Glu?Arg?Lys?Leu?Ser?Ser?Val?Val?Glu?Thr?Tyr?Thr?His?Asn

340 345 350

Val?Glu?Lys?His?Val?Pro?Ile?His?Pro?Glu?Tyr?Val?Ala?Ser?Ile?Leu

355 360 365

Asn?Glu?Leu?Ala?Asp?Lys?Asp?Ala?Val?Phe?Thr?Val?Asp?Thr?Gly?Met

370 375 380

Cys?Asn?Val?Trp?His?Ala?Arg?Tyr?Ile?Glu?Asn?Pro?Glu?Gly?Thr?Arg

385 390 395 400

Asp?Phe?Val?Gly?Ser?Phe?Arg?His?Gly?Thr?Met?Ala?Asn?Ala?Leu?Pro

405 410 415

His?Ala?Ile?Gly?Ala?Gln?Ser?Val?Asp?Arg?Asn?Arg?Gln?Val?Ile?Ala

420 425 430

Met?Cys?Gly?Asp?Gly?Gly?Leu?Gly?Met?Leu?Leu?Gly?Glu?Leu?Leu?Thr

435 440 445

Val?Lys?Leu?His?Gln?Leu?Pro?Leu?Lys?Ala?Val?Val?Phe?Asn?Asn?Ser

450 455 460

Ser?Leu?Gly?Met?Val?Lys?Leu?Glu?Met?Leu?Val?Glu?Gly?Gln?Pro?Glu

465 470 475 480

Phe?Gly?Thr?Asp?His?Glu?Glu?Val?Asn?Phe?Ala?Glu?Ile?Ala?Ala?Ala

485 490 495

Ala?Gly?Ile?Lys?Ser?Val?Arg?Ile?Thr?Asp?Pro?Lys?Lys?Val?Arg?Glu

500 505 510

Gln?Leu?Ala?Glu?Ala?Leu?Ala?Tyr?Pro?Gly?Pro?Val?Leu?Ile?Asp?Ile

515 520 525

Val?Thr?Asp?Pro?Asn?Ala?Leu?Ser?Ile?Pro?Pro?Thr?Ile?Thr?Trp?Glu

530 535 540

Gln?Val?Met?Gly?Phe?Ser?Lys?Ala?Ala?Thr?Arg?Thr?Val?Phe?Gly?Gly

545 550 555 560

Gly?Val?Gly?Ala?Met?Ile?Asp?Leu?Ala?Arg?Ser?Asn?Ile?Arg?Asn?Ile

565 570 575

Pro?Thr?Pro

<210>87

<211>552

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(88)..?(552)

<223>FRXA02807

<400>87

aaagcgtggc?aacaactgga?atttaagagc?acaattgaag?tcgcaccaag?ttaggcaaca?60

caatagccat?aacgttgagg?agttcag?atg?gca?cac?agc?tac?gca?gaa?caa?tta?114

Met?Ala?His?Ser?Tyr?Ala?Glu?Gln?Leu

1 5

att?gac?act?ttg?gaa?gct?caa?ggt?gtg?aag?cga?att?tat?ggt?ttg?gtg 162

Ile?Asp?Thr?Leu?Glu?Ala?Gln?Gly?Val?Lys?Arg?Ile?Tyr?Gly?Leu?Val

10 15 20 25

ggt?gac?agc?ctt?aat?ccg?atc?gtg?gat?gct?gtc?cgc?caa?tca?gat?att 210

Gly?Asp?Ser?Leu?Asn?Pro?Ile?Val?Asp?Ala?Val?Arg?Gln?Ser?Asp?Ile

30 35 40

gag?tgg?gtg?cac?gtt?cga?aat?gag?gaa?gcg?gcg?gcg?ttt?gca?gcc?ggt 258

Glu?Trp?Val?His?Val?Arg?Asn?Glu?Glu?Ala?Ala?Ala?Phe?Ala?Ala?Gly

45 50 55

gcg?gaa?tcg?ttg?atc?act?ggg?gag?ctg?gca?gta?tgt?gct?gct?tct?tgt 306

Ala?Glu?Ser?Leu?Ile?Thr?Gly?Glu?Leu?Ala?Val?Cys?Ala?Ala?Ser?Cys

60 65 70

ggt?cct?gga?aac?aca?cac?ctg?att?cag?ggt?ctt?tat?gat?tcg?cat?cga 354

Gly?Pro?Gly?Asn?Thr?His?Leu?Ile?Gln?Gly?Leu?Tyr?Asp?Ser?His?Arg

75 80 85

aat?ggt?gcg?aag?gtg?ttg?gcc?atc?gct?agc?cat?att?ccg?agt?gcc?cag 402

Asn?Gly?Ala?Lys?Val?Leu?Ala?Ile?Ala?Ser?His?Ile?Pro?Ser?Ala?Gln

90 95 100 105

att?ggt?tcg?acg?ttc?ttc?cag?gaa?acg?cat?ccg?gag?att?ttg?ttt?aag 450

Ile?Gly?Ser?Thr?Phe?Phe?Gln?Glu?Thr?His?Pro?Glu?Ile?Leu?Phe?Lys

110 115 120

gaa?tgc?tct?ggt?tac?tgc?gag?atg?gtg?aat?ggt?ggt?gag?cag?ggt?gaa 498

Glu?Cys?Ser?Gly?Tyr?Cys?Glu?Met?Val?Asn?Gly?Gly?Glu?Gln?Gly?Glu

125 130 135

cgc?att?ttg?cat?cac?gcg?att?cag?tcc?acc?atg?gcg?ggt?aaa?ggt?gtg 546

Arg?Ile?Leu?His?His?Ala?Ile?Gln?Ser?Thr?Met?Ala?Gly?Lys?Gly?Val

140 145 150

tcg?gtg 552

Ser?Val

155

<210>88

<211>155

<212>PRT

＜213〉Corynebacterium glutamicum

<400>88

Met?Ala?His?Ser?Tyr?Ala?Glu?Gln?Leu?Ile?Asp?Thr?Leu?Glu?Ala?Gln

1 5 10 15

Gly?Val?Lys?Arg?Ile?Tyr?Gly?Leu?Val?Gly?Asp?Ser?Leu?Asn?Pro?Ile

20 25 30

Val?Asp?Ala?Val?Arg?Gln?Ser?Asp?Ile?Glu?Trp?Val?His?Val?Arg?Asn

35 40 45

Glu?Glu?Ala?Ala?Ala?Phe?Ala?Ala?Gly?Ala?Glu?Ser?Leu?Ile?Thr?Gly

50 55 60

Glu?Leu?Ala?Val?Cys?Ala?Ala?Ser?Cys?Gly?Pro?Gly?Asn?Thr?His?Leu

65 70 75 80

Ile?Gln?Gly?Leu?Tyr?Asp?Ser?His?Arg?Asn?Gly?Ala?Lys?Val?Leu?Ala

85 90 95

Ile?Ala?Ser?His?Ile?Pro?Ser?Ala?Gln?Ile?Gly?Ser?Thr?Phe?Phe?Gln

100 105 110

Glu?Thr?His?Pro?Glu?Ile?Leu?Phe?Lys?Glu?Cys?Ser?Gly?Tyr?Cys?Glu

115 120 125

Met?Val?Asn?Gly?Gly?Glu?Gln?Gly?Glu?Arg?Ile?Leu?His?His?Ala?Ile

130 135 140

Gln?Ser?Thr?Met?Ala?Gly?Lys?Gly?Val?Ser?Val

145 150 155

<210>89

<211>944

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(921)

<223>FRXA00635

<400>89

ggt?acg?gat?ttc?cct?tat?tct?gat?ttc?ctt?cct?aaa?gac?aac?gtt?gcc 48

Gly?Thr?Asp?Phe?Pro?Tyr?Ser?Asp?Phe?Leu?Pro?Lys?Asp?Asn?Val?Ala

1 5 10 15

cag?gtg?gat?atc?aac?ggt?gcg?cac?att?ggt?cga?cgt?acc?acg?gtg?aag 96

Gln?Val?Asp?Ile?Asn?Gly?Ala?His?Ile?Gly?Arg?Arg?Thr?Thr?Val?Lys

20 25 30

tat?ccg?gtg?acc?ggt?gat?gtt?gct?gca?aca?atc?gaa?aat?att?ttg?cct 144

Tyr?Pro?Val?Thr?Gly?Asp?Val?Ala?Ala?Thr?Ile?Glu?Asn?Ile?Leu?Pro

35 40 45

cat?gtg?aag?gaa?aaa?aca?gat?cgt?tcc?ttc?ctt?gat?cgg?atg?ctc?aag 192

His?Val?Lys?Glu?Lys?Thr?Asp?Arg?Ser?Phe?Leu?Asp?Arg?Met?Leu?Lys

50 55 60

gca?cac?gag?cgt?aag?ttg?agc?tcg?gtg?gta?gag?acg?tac?aca?cat?aac 240

Ala?His?Glu?Arg?Lys?Leu?Ser?Ser?Val?Val?Glu?Thr?Tyr?Thr?His?Asn

65 70 75 80

gtc?gag?aag?cat?gtg?cct?att?cac?cct?gaa?tac?gtt?gcc?tct?att?ttg 288

Val?Glu?Lys?His?Val?Pro?Ile?His?Pro?Glu?Tyr?Val?Ala?Ser?Ile?Leu

85 90 95

aac?gag?ctg?gcg?gat?aag?gat?gcg?gtg?ttt?act?gtg?gat?acc?ggc?atg 336

Asn?Glu?Leu?Ala?Asp?Lys?Asp?Ala?Val?Phe?Thr?Val?Asp?Thr?Gly?Met

100 105 110

tgc?aat?gtg?tgg?cat?gcg?agg?tac?atc?gag?aat?ccg?gag?gga?acg?cgc 384

Cys?Asn?Val?Trp?His?Ala?Arg?Tyr?Ile?Glu?Asn?Pro?Glu?Gly?Thr?Arg

115 120 125

gac?ttt?gtg?ggt?tca?ttc?cgc?cac?ggc?acg?atg?gct?aat?gcg?ttg?cct 432

Asp?Phe?Val?Gly?Ser?Phe?Arg?His?Gly?Thr?Met?Ala?Asn?Ala?Leu?Pro

130 135 140

cat?gcg?att?ggt?gcg?caa?agt?gtt?gat?cga?aac?cgc?cag?gtg?atc?gcg 480

His?Ala?Ile?Gly?Ala?Gln?Ser?Val?Asp?Arg?Asn?Arg?Gln?Val?Ile?Ala

145 150 155 160

atg?tgt?ggc?gat?ggt?ggt?ttg?ggc?atg?ctg?ctg?ggt?gag?ctt?ctg?acc 528

Met?Cys?Gly?Asp?Gly?Gly?Leu?Gly?Met?Leu?Leu?Gly?Glu?Leu?Leu?Thr

165 170 175

gtt?aag?ctg?cac?caa?ctt?ccg?ctg?aag?gct?gtg?gtg?ttt?aac?aac?agt 576

Val?Lys?Leu?His?Gln?Leu?Pro?Leu?Lys?Ala?Val?Val?Phe?Asn?Asn?Ser

180 185 190

tct?ttg?ggc?atg?gtg?aag?ttg?gag?atg?ctc?gtg?gag?gga?cag?cca?gaa 624

Ser?Leu?Gly?Met?Val?Lys?Leu?Glu?Met?Leu?Val?Glu?Gly?Gln?Pro?Glu

195 200 205

ttt?ggt?act?gac?cat?gag?gaa?gtg?aat?ttc?gca?gag?att?gcg?gcg?gct 672

Phe?Gly?Thr?Asp?His?Glu?Glu?Val?Asn?Phe?Ala?Glu?Ile?Ala?Ala?Ala

210 215 220

gcg?ggt?atc?aaa?tcg?gta?cgc?atc?acc?gat?ccg?aag?aaa?gtt?cgc?gag 720

Ala?Gly?Ile?Lys?Ser?Val?Arg?Ile?Thr?Asp?Pro?Lys?Lys?Val?Arg?Glu

225 230 235 240

cag?cta?gct?gag?gca?ttg?gca?tat?cct?gga?cct?gta?ctg?atc?gat?atc 768

Gln?Leu?Ala?Glu?Ala?Leu?Ala?Tyr?Pro?Gly?Pro?Val?Leu?Ile?Asp?Ile

245 250 255

gtc?acg?gat?cct?aat?gcg?ctg?tcg?atc?cca?cca?acc?atc?acg?tgg?gaa 816

Val?Thr?Asp?Pro?Asn?Ala?Leu?Ser?Ile?Pro?Pro?Thr?Ile?Thr?Trp?Glu

260 265 270

cag?gtc?atg?gga?ttc?agc?aag?gcg?gcc?acc?cga?acc?gtc?ttt?ggt?gga 864

Gln?Val?Met?Gly?Phe?Ser?Lys?Ala?Ala?Thr?Arg?Thr?Val?Phe?Gly?Gly

275 280 285

gga?gta?gga?gcg?atg?atc?gat?ctg?gcc?cgt?tcg?aac?ata?agg?aat?att 912

Gly?Val?Gly?Ala?Met?Ile?Asp?Leu?Ala?Arg?Ser?Asn?Ile?Arg?Asn?Ile

290 295 300

cct?act?cca?tgatgattga?tacacctgct?gtt 944

Pro?Thr?Pro

305

<210>90

<211>307

<212>PRT

＜213〉Corynebacterium glutamicum

<400>90

Gly?Thr?Asp?Phe?Pro?Tyr?Ser?Asp?Phe?Leu?Pro?Lys?Asp?Asn?Val?Ala

1 5 10 15

Gln?Val?Asp?Ile?Asn?Gly?Ala?His?Ile?Gly?Arg?Arg?Thr?Thr?Val?Lys

20 25 30

Tyr?Pro?Val?Thr?Gly?Asp?Val?Ala?Ala?Thr?Ile?Glu?Asn?Ile?Leu?Pro

35 40 45

His?Val?Lys?Glu?Lys?Thr?Asp?Arg?Ser?Phe?Leu?Asp?Arg?Met?Leu?Lys

50 55 60

Ala?His?Glu?Arg?Lys?Leu?Ser?Ser?Val?Val?Glu?Thr?Tyr?Thr?His?Asn

65 70 75 80

Val?Glu?Lys?His?Val?Pro?Ile?His?Pro?Glu?Tyr?Val?Ala?Ser?Ile?Leu

85 90 95

Asn?Glu?Leu?Ala?Asp?Lys?Asp?Ala?Val?Phe?Thr?Val?Asp?Thr?Gly?Met

100 105 110

Cys?Asn?Val?Trp?His?Ala?Arg?Tyr?Ile?Glu?Asn?Pro?Glu?Gly?Thr?Arg

115 120 125

Asp?Phe?Val?Gly?Ser?Phe?Arg?His?Gly?Thr?Met?Ala?Asn?Ala?Leu?Pro

130 135 140

His?Ala?Ile?Gly?Ala?Gln?Ser?Val?Asp?Arg?Asn?Arg?Gln?Val?Ile?Ala

145 150 155 160

Met?Cys?Gly?Asp?Gly?Gly?Leu?Gly?Met?Leu?Leu?Gly?Glu?Leu?Leu?Thr

165 170 175

Val?Lys?Leu?His?Gln?Leu?Pro?Leu?Lys?Ala?Val?Val?Phe?Asn?Asn?Ser

180 185 190

Ser?Leu?Gly?Met?Val?Lys?Leu?Glu?Met?Leu?Val?Glu?Gly?Gln?Pro?Glu

195 200 205

Phe?Gly?Thr?Asp?His?Glu?Glu?Val?Asn?Phe?Ala?Glu?Ile?Ala?Ala?Ala

210 215 220

Ala?Gly?Ile?Lys?Ser?Val?Arg?Ile?Thr?Asp?Pro?Lys?Lys?Val?Arg?Glu

225 230 235 240

Gln?Leu?Ala?Glu?Ala?Leu?Ala?Tyr?Pro?Gly?Pro?Val?Leu?Ile?Asp?Ile

245 250 255

Val?Thr?Asp?Pro?Asn?Ala?Leu?Ser?Ile?Pro?Pro?Thr?Ile?Thr?Trp?Glu

260 265 270

Gln?Val?Met?Gly?Phe?Ser?Lys?Ala?Ala?Thr?Arg?Thr?Val?Phe?Gly?Gly

275 280 285

Gly?Val?Gly?Ala?Met?Ile?Asp?Leu?Ala?Arg?Ser?Asn?Ile?Arg?Asn?Ile

290 295 300

Pro?Thr?Pro

305

<210>91

<211>954

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(931)

<223>RXN03044

<400>91

tacgccaccc?acggcaaggc?catgattccg?ctgtacatct?tctactcgat?gttcgggatt?60

ccagcgcacc?ggtgactcca?tctgggcagc?agccgatcag?atg?gca?cgt?ggc?ttc 115

Met?Ala?Arg?Gly?Phe

1 5

ctc?ttg?ggc?gct?acc?gca?ggt?cgc?acc?acc?ctg?acc?ggt?gaa?ggc?ctc 163

Leu?Leu?Gly?Ala?Thr?Ala?Gly?Arg?Thr?Thr?Leu?Thr?Gly?Glu?Gly?Leu

10 15 20

cag?cac?atg?gat?gga?cac?tcc?cct?gtc?ttg?gct?tcc?acc?aac?gag?ggt 211

Gln?His?Met?Asp?Gly?His?Ser?Pro?Val?Leu?Ala?Ser?Thr?Asn?Glu?Gly

25 30 35

gtc?gag?acc?tac?gac?cca?tcc?ttt?gcg?tac?gag?atc?gca?cac?ctg?gtt 259

Val?Glu?Thr?Tyr?Asp?Pro?Ser?Phe?Ala?Tyr?Glu?Ile?Ala?His?Leu?Val

40 45 50

cac?cgt?ggc?atc?gac?cgc?atg?tac?ggc?cca?ggc?aag?ggt?gaa?gat?gtt 307

His?Arg?Gly?Ile?Asp?Arg?Met?Tyr?Gly?Pro?Gly?Lys?Gly?Glu?Asp?Val

55 60 65

atc?tac?tac?atc?acc?atc?tac?aac?gag?cca?acc?cca?cag?cca?gct?gag 355

Ile?Tyr?Tyr?Ile?Thr?Ile?Tyr?Asn?Glu?Pro?Thr?Pro?Gln?Pro?Ala?Glu

70 75 80 85

cca?gaa?gga?ctg?gac?gta?gaa?ggc?ctg?cac?aag?ggc?atc?tac?ctc?tac 403

Pro?Glu?Gly?Leu?Asp?Val?Glu?Gly?Leu?His?Lys?Gly?Ile?Tyr?Leu?Tyr

90 95 100

tcc?cgc?ggt?gaa?ggc?acc?ggc?cat?gag?gca?aac?atc?ttg?gct?tcc?ggt 451

Ser?Arg?Gly?Glu?Gly?Thr?Gly?His?Glu?Ala?Asn?Ile?Leu?Ala?Ser?Gly

105 110 115

gtt?ggt?atg?cag?tgg?gct?ctc?aag?gct?gca?tcc?atc?ctt?gag?gct?gac 499

ValGly?Met?Gln?Trp?Ala?Leu?Lys?Ala?Ala?Ser?Ile?Leu?Glu?Ala?Asp

120 125 130

tac?gga?gtt?cgt?gcc?aac?att?tac?tcc?gct?act?tct?tgg?gtt?aac?ttg 547

Tyr?Gly?Val?Arg?Ala?Asn?Ile?Tyr?Ser?Ala?Thr?Ser?Trp?Val?Asn?Leu

135 140 145

gct?cgc?gat?ggc?gct?gct?cgt?aac?aag?gca?cag?ctg?cgc?aac?cca?ggt 595

Ala?Arg?Asp?Gly?Ala?Ala?Arg?Asn?Lys?Ala?Gln?Leu?Arg?Asn?Pro?Gly

150 155 160 165

gca?gat?gct?ggc?gag?gca?ttc?gta?acc?acc?cag?ctg?aag?cag?acc?tcc 643

Ala?Asp?Ala?Gly?Glu?Ala?Phe?Val?Thr?Thr?Gln?Leu?Lys?Gln?Thr?Ser

170 175 180

ggc?cca?tac?gtt?gca?gtg?tct?gac?ttc?tcc?act?gat?ctg?cca?aac?cag 691

Gly?Pro?Tyr?Val?Ala?Val?Ser?Asp?Phe?Ser?Thr?Asp?Leu?Pro?Asn?Gln

185 190 195

atc?cgt?gaa?tgg?gtc?cca?ggc?gac?tac?acc?gtt?ctc?ggt?gca?gat?ggc 739

Ile?Arg?Glu?Trp?Val?Pro?Gly?Asp?Tyr?Thr?Val?Leu?Gly?Ala?Asp?Gly

200 205 210

ttc?ggt?ttc?tct?gat?acc?cgc?cca?gct?gct?cgt?cgc?ttc?ttc?aac?atc 787

Phe?Gly?Phe?Ser?Asp?Thr?Arg?Pro?Ala?Ala?Arg?Arg?Phe?Phe?Asn?Ile

215 220 225

gac?gct?gag?tcc?att?gtt?gtt?gca?gtg?ctg?aac?tcc?ctg?gca?cgc?gaa 835

Asp?Ala?Glu?Ser?Ile?Val?Val?Ala?Val?Leu?Asn?Ser?Leu?Ala?Arg?Glu

230 235 240 245

ggc?aag?atc?gac?gtc?tcc?gtt?gct?gct?cag?gct?gct?gag?aag?ttc?aag 883

Gly?Lys?Ile?Asp?Val?Ser?Val?Ala?Ala?Gln?Ala?Ala?Glu?Lys?Phe?Lys

250 255 260

ttg?gat?gat?cct?acg?agt?gtt?tcc?gta?gat?cca?aac?gct?cct?gag?gaa 931

Leu?Asp?Asp?Pro?Thr?Ser?Val?Ser?Val?Asp?Pro?Asn?Ala?Pro?Glu?Glu

265 270 275

taaatcacct?caagggacag?ata 954

<210>92

<211>277

<212>PRT

＜213〉Corynebacterium glutamicum

<400>92

Met?Ala?Arg?Gly?Phe?Leu?Leu?Gly?Ala?Thr?Ala?Gly?Arg?Thr?Thr?Leu

1 5 10 15

Thr?Gly?Glu?Gly?Leu?Gln?His?Met?Asp?Gly?His?Ser?Pro?Val?Leu?Ala

20 25 30

Ser?Thr?Asn?Glu?Gly?Val?Glu?Thr?Tyr?Asp?Pro?Ser?Phe?Ala?Tyr?Glu

35 40 45

Ile?Ala?His?Leu?Val?His?Arg?Gly?Ile?Asp?Arg?Met?Tyr?Gly?Pro?Gly

50 55 60

Lys?Gly?Glu?Asp?Val?Ile?Tyr?Tyr?Ile?Thr?Ile?Tyr?Asn?Glu?Pro?Thr

65 70 75 80

Pro?Gln?Pro?Ala?Glu?Pro?Glu?Gly?Leu?Asp?Val?Glu?Gly?Leu?His?Lys

85 90 95

Gly?Ile?Tyr?Leu?Tyr?Ser?Arg?Gly?Glu?Gly?Thr?Gly?His?Glu?Ala?Asn

100 105 110

Ile?Leu?Ala?Ser?Gly?Val?Gly?Met?Gln?Trp?Ala?Leu?Lys?Ala?Ala?Ser

115 120 125

Ile?Leu?Glu?Ala?Asp?Tyr?Gly?Val?Arg?Ala?Asn?Ile?Tyr?Ser?Ala?Thr

130 135 140

Ser?Trp?Val?Asn?Leu?Ala?Arg?Asp?Gly?Ala?Ala?Arg?Asn?Lys?Ala?Gln

145 150 155 160

Leu?Arg?Asn?Pro?Gly?Ala?Asp?Ala?Gly?Glu?Ala?Phe?Val?Thr?Thr?Gln

165 170 175

Leu?Lys?Gln?Thr?Ser?Gly?Pro?Tyr?Val?Ala?Val?Ser?Asp?Phe?Ser?Thr

180 185 190

Asp?Leu?Pro?Asn?Gln?Ile?Arg?Glu?Trp?Val?Pro?Gly?Asp?Tyr?Thr?Val

195 200 205

Leu?Gly?Ala?Asp?Gly?Phe?Gly?Phe?Ser?Asp?Thr?Arg?Pro?Ala?Ala?Arg

210 215 220

Arg?Phe?Phe?Asn?Ile?Asp?Ala?Glu?Ser?Ile?Val?Val?Ala?Val?Leu?Asn

225 230 235 240

Ser?Leu?Ala?Arg?Glu?Gly?Lys?Ile?Asp?Val?Ser?Val?Ala?Ala?Gln?Ala

245 250 255

Ala?Glu?Lys?Phe?Lys?Leu?Asp?Asp?Pro?Thr?Ser?Val?Ser?Val?Asp?Pro

260 265 270

Asn?Ala?Pro?Glu?Glu

275

<210>93

<211>302

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(279)

<223>FRXA02852

<400>93

gtt?gca?gtg?tct?gac?ttc?tcc?act?gat?ctg?cca?aac?cag?atc?cgt?gaa 48

Val?Ala?Val?Ser?Asp?Phe?Ser?Thr?Asp?Leu?Pro?Asn?Gln?Ile?Arg?Glu

1 5 10 15

tgg?gtc?cca?ggc?gac?tac?acc?gtt?ctc?ggt?gca?gat?ggc?ttc?ggt?ttc 96

Trp?Val?Pro?Gly?Asp?Tyr?Thr?Val?Leu?Gly?Ala?Asp?Gly?Phe?Gly?Phe

20 25 30

tct?gat?acc?cgc?cca?gct?gct?cgt?cgc?ttc?ttc?aac?atc?gac?gct?gag 144

Ser?Asp?Thr?Arg?Pro?Ala?Ala?Arg?Arg?Phe?Phe?Asn?Ile?Asp?Ala?Glu

35 40 45

tcc?att?gtt?gtt?gca?gtg?ctg?aac?tcc?ctg?gca?cgc?gaa?ggc?aag?atc 192

Ser?Ile?Val?Val?Ala?Val?Leu?Asn?Ser?Leu?Ala?Arg?Glu?Gly?Lys?Ile

50 55 60

gac?gtc?tcc?gtt?gct?gct?cag?gct?gct?gag?aag?ttc?aag?ttg?gat?gat 240

Asp?Val?Ser?Val?Ala?Ala?Gln?Ala?Ala?Glu?Lys?Phe?Lys?Leu?Asp?Asp

65 70 75 80

cct?acg?agt?gtt?tcc?gta?gat?cca?aac?gct?cct?gag?gaa?taaatcacct 289

Pro?Thr?Ser?Val?Ser?Val?Asp?Pro?Asn?Ala?Pro?Glu?Glu

85 90

caagggacag?ata 302

<210>94

<211>93

<212>PRT

＜213〉Corynebacterium glutamicum

<400>94

Val?Ala?Val?Ser?Asp?Phe?Ser?Thr?Asp?Leu?Pro?Asn?Gln?Ile?Arg?Glu

1 5 10 15

Trp?Val?Pro?Gly?Asp?Tyr?Thr?Val?Leu?Gly?Ala?Asp?Gly?Phe?Gly?Phe

20 25 30

Ser?Asp?Thr?Arg?Pro?Ala?Ala?Arg?Arg?Phe?Phe?Asn?Ile?Asp?Ala?Glu

35 40 45

Ser?Ile?Val?Val?Ala?Val?Leu?Asn?Ser?Leu?Ala?Arg?Glu?Gly?Lys?Ile

50 55 60

Asp?Val?Ser?Val?Ala?Ala?Gln?Ala?Ala?Glu?Lys?Phe?Lys?Leu?Asp?Asp

65 70 75 80

Pro?Thr?Ser?Val?Ser?Val?Asp?Pro?Asn?Ala?Pro?Glu?Glu

85 90

<210>95

<211>954

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(931)

<223>FRXA00268

<400>95

tacgccaccc?acggcaaggc?catgattccg?ctgtacatct?tctactcgat?gttcgggatt?60

ccagcgcacc?ggtgactcca?tttgggcagc?agccgatcag?atg?gca?cgt?ggc?ttc 115

Met?Ala?Arg?Gly?Phe

1 5

ttt?ttg?ggc?gct?acc?gca?ggt?cgc?acc?acc?ttg?acc?ggt?gaa?ggc?ctc 163

Phe?Leu?Gly?Ala?Thr?Ala?Gly?Arg?Thr?Thr?Leu?Thr?Gly?Glu?Gly?Leu

10 15 20

cag?cac?atg?gat?gga?cac?tcc?cct?gtt?ttg?gct?tcc?acc?aac?gag?ggt 211

Gln?His?Met?Asp?Gly?His?Ser?Pro?Val?Leu?Ala?Ser?Thr?Asn?Glu?Gly

25 30 35

gtc?gag?acc?tac?gac?cca?tcc?ttt?gcg?tac?gag?atc?gca?cac?ctg?gtt 259

Val?Glu?Thr?Tyr?Asp?Pro?Ser?Phe?Ala?Tyr?Glu?Ile?Ala?His?Leu?Val

40 45 50

cac?cgt?ggc?atc?gac?cgc?atg?tac?ggc?cca?ggc?aag?ggt?gaa?gat?gtt 307

His?Arg?Gly?Ile?Asp?Arg?Met?Tyr?Gly?Pro?Gly?Lys?Gly?Glu?Asp?Val

55 60 65

atc?tac?tac?atc?acc?atc?tac?aac?gag?cca?acc?cca?cag?cca?gct?gag 355

Ile?Tyr?Tyr?Ile?Thr?Ile?Tyr?Asn?Glu?Pro?Thr?Pro?Gln?Pro?Ala?Glu

70 75 80 85

cca?gaa?gga?ctg?gac?gta?gaa?ggc?ctg?cac?aag?ggc?atc?tac?ctc?tac 403

Pro?Glu?Gly?Leu?Asp?Val?Glu?Gly?Leu?His?Lys?Gly?Ile?Tyr?Leu?Tyr

90 95 100

tcc?cgc?ggt?gaa?ggc?acc?ggc?cat?gag?gca?aac?atc?ttg?gct?tcc?ggt 451

Ser?Arg?Gly?Glu?Gly?Thr?Gly?His?Glu?Ala?Asn?Ile?Leu?Ala?Ser?Gly

105 110 115

gtt?ggt?atg?cag?tgg?gct?ctc?aag?gct?gca?tcc?atc?ctt?gag?gct?gac 499

Val?Gly?Met?Gln?Trp?Ala?Leu?Lys?Ala?Ala?Ser?Ile?Leu?Glu?Ala?Asp

120 125 130

tac?gga?gtt?cgt?gcc?aac?att?tac?tcc?gct?act?tct?tgg?gtt?aac?ttg 547

Tyr?Gly?Val?Arg?Ala?Asn?Ile?Tyr?Ser?Ala?Thr?Ser?Trp?Val?Asn?Leu

135 140 145

gct?cgc?gat?ggc?gct?gct?cgt?aac?aag?gca?cag?ctg?cgc?aac?cca?ggt 595

Ala?Arg?Asp?Gly?Ala?Ala?Arg?Asn?Lys?Ala?Gln?Leu?Arg?Asn?Pro?Gly

150 155 160 165

gca?gat?gct?ggc?gag?gca?ttc?gta?acc?acc?cag?ctg?aag?cag?acc?tcc 643

Ala?Asp?Ala?Gly?Glu?Ala?Phe?Val?Thr?Thr?Gln?Leu?Lys?Gln?Thr?Ser

170 175 180

ggc?cca?tac?gtt?gca?gtg?tct?gac?ttc?tcc?act?gat?ctg?cca?aac?cag 691

Gly?Pro?Tyr?Val?Ala?Val?Ser?Asp?Phe?Ser?Thr?Asp?Leu?Pro?Asn?Gln

185 190 195

atc?cgt?gaa?tgg?gtc?cca?ggc?gac?tac?acc?gtt?ctc?ggt?gca?gat?ggc 739

Ile?Arg?Glu?Trp?Val?Pro?Gly?Asp?Tyr?Thr?Val?Leu?Gly?Ala?Asp?Gly

200 205 210

ttc?ggt?ttc?tct?gat?acc?cgc?cca?gct?gct?cgt?cgc?ttc?ttc?aac?atc 787

Phe?Gly?Phe?Ser?Asp?Thr?Arg?Pro?Ala?Ala?Arg?Arg?Phe?Phe?Asn?Ile

215 220 225

gac?gct?gag?tcc?att?gtt?gtt?gca?gtg?ctg?aac?tcc?ctg?gca?cgc?gaa 835

Asp?Ala?Glu?Ser?Ile?Val?Val?Ala?Val?Leu?Asn?Ser?Leu?Ala?Arg?Glu

230 235 240 245

ggc?aag?atc?gac?gtc?tcc?gtt?gct?gct?cag?gct?gct?gag?aag?ttc?aag 883

Gly?Lys?Ile?Asp?Val?Ser?Val?Ala?Ala?Gln?Ala?Ala?Glu?Lys?Phe?Lys

250 255 260

ttg?gat?gat?cct?acg?agt?gtt?tcc?gta?gat?cca?aac?gct?cct?gag?gaa 931

Leu?Asp?Asp?Pro?Thr?Ser?Val?Ser?Val?Asp?Pro?Asn?Ala?Pro?Glu?Glu

265 270 275

taaatcacct?caagggacag?ata 954

<210>96

<211>277

<212>PRT

＜213〉Corynebacterium glutamicum

<400>96

Met?Ala?Arg?Gly?Phe?Phe?Leu?Gly?Ala?Thr?Ala?Gly?Arg?Thr?Thr?Leu

1 5 10 15

Thr?Gly?Glu?Gly?Leu?Gln?His?Met?Asp?Gly?His?Ser?Pro?Val?Leu?Ala

20 25 30

Ser?Thr?Asn?Glu?Gly?Val?Glu?Thr?Tyr?Asp?Pro?Ser?Phe?Ala?Tyr?Glu

35 40 45

Ile?Ala?His?Leu?Val?His?Arg?Gly?Ile?Asp?Arg?Met?Tyr?Gly?Pro?Gly

50 55 60

Lys?Gly?Glu?Asp?Val?Ile?Tyr?Tyr?Ile?Thr?Ile?Tyr?Asn?Glu?Pro?Thr

65 70 75 80

Pro?Gln?Pro?Ala?Glu?Pro?Glu?Gly?Leu?Asp?Val?Glu?Gly?Leu?His?Lys

85 90 95

Gly?Ile?Tyr?Leu?Tyr?Ser?Arg?Gly?Glu?Gly?Thr?Gly?His?Glu?Ala?Asn

100 105 110

Ile?Leu?Ala?Ser?Gly?Val?Gly?Met?Gln?Trp?Ala?Leu?Lys?Ala?Ala?Ser

115 120 125

Ile?Leu?Glu?Ala?Asp?Tyr?Gly?Val?Arg?Ala?Asn?Ile?Tyr?Ser?Ala?Thr

130 135 140

Ser?Trp?Val?Asn?Leu?Ala?Arg?Asp?Gly?Ala?Ala?Arg?Asn?Lys?Ala?Gln

145 150 155 160

Leu?Arg?Asn?Pro?Gly?Ala?Asp?Ala?Gly?Glu?Ala?Phe?Val?Thr?Thr?Gln

165 170 175

Leu?Lys?Gln?Thr?Ser?Gly?Pro?Tyr?Val?Ala?Val?Ser?Asp?Phe?Ser?Thr

180 185 190

Asp?Leu?Pro?Asn?Gln?Ile?Arg?Glu?Trp?Val?Pro?Gly?Asp?Tyr?Thr?Val

195 200 205

Leu?Gly?Ala?Asp?Gly?Phe?Gly?Phe?Ser?Asp?Thr?Arg?Pro?Ala?Ala?Arg

210 215 220

Arg?Phe?Phe?Asn?Ile?Asp?Ala?Glu?Ser?Ile?Val?Val?Ala?Val?Leu?Asn

225 230 235 240

Ser?Leu?Ala?Arg?Glu?Gly?Lys?Ile?Asp?Val?Ser?Val?Ala?Ala?Gln?Ala

245 250 255

Ala?Glu?Lys?Phe?Lys?Leu?Asp?Asp?Pro?Thr?Ser?Val?Ser?Val?Asp?Pro

260 265 270

Asn?Ala?Pro?Glu?Glu

275

<210>97

<211>508

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(508)

<223>RXN03086

<400>97

ttcgtgcact?tcggcgtgtc?acaattaggt?acgaccaaga?atgggaccgg?gaaaccggga?60

cgtataaacg?aaataaaaca?ttccaacagg?aggtgtggaa?atg?gcc?gat?caa?gca 115

Met?Ala?Asp?Gln?Ala

1 5

aaa?ctt?ggt?ggc?aag?ccc?tcg?gat?gac?tct?aac?ttc?gcg?atg?arc?cgc 163

Lys?Leu?Gly?Gly?Lys?Pro?Ser?Asp?Asp?Ser?Asn?Phe?Ala?Met?Ile?Arg

10 15 20

gat?ggc?gtg?gca?tct?tat?ttg?aac?gac?tca?gat?ccg?gag?gag?acc?aac 211

Asp?Gly?Val?Ala?Ser?Tyr?Leu?Asn?Asp?Ser?Asp?Pro?Glu?Glu?Thr?Asn

25 30 35

gag?tgg?atg?gat?tca?ctc?gac?gga?tta?ctc?cag?gag?tct?tct?cca?gaa 259

Glu?Trp?Met?Asp?Ser?Leu?Asp?Gly?Leu?Leu?Gln?Glu?Ser?Ser?Pro?Glu

40 45 50

cgt?gct?cgt?tac?ctc?atg?ctt?cgt?ttg?ctt?gag?cgt?gca?tct?gca?aag 307

Arg?Ala?Arg?Tyr?Leu?Met?Leu?Arg?Leu?Leu?Glu?Arg?Ala?Ser?Ala?Lys

55 60 65

cgc?gta?tct?ctt?ccc?cca?atg?acg?tca?acc?gac?tac?gtc?aac?acc?att 355

Arg?Val?Ser?Leu?Pro?Pro?Met?Thr?Ser?Thr?Asp?Tyr?Val?Asn?Thr?Ile

70 75 80 85

cca?acc?tct?atg?gaa?cct?gaa?ttc?cca?ggc?gat?gag?gaa?atg?gag?aag 403

Pro?Thr?Ser?Met?Glu?Pro?Glu?Phe?Pro?Gly?Asp?Glu?Glu?Met?Glu?Lys

90 95 100

cgt?tac?cgt?cgt?tgg?att?cgc?tgg?aac?gca?gcc?atc?atg?gtt?cac?cgc 451

Arg?Tyr?Arg?Arg?Trp?Ile?Arg?Trp?Asn?Ala?Ala?Ile?Met?Val?His?Arg

105 110 115

gct?cag?cga?cca?ggc?atc?ggc?gtc?ggc?gga?cac?att?tcc?act?tac?gca 499

Ala?Gln?Arg?Pro?Gly?Ile?Gly?Val?Gly?Gly?His?Ile?Ser?Thr?Tyr?Ala

120 125 130

ggc?gca?gcc 508

Gly?Ala?Ala

135

<210>98

<211>136

<212>PRT

＜213〉Corynebacterium glutamicum

<400>98

Met?Ala?Asp?Gln?Ala?Lys?Leu?Gly?Gly?Lys?Pro?Ser?Asp?Asp?Ser?Asn

1 5 10 15

Phe?Ala?Met?Ile?Arg?Asp?Gly?Val?Ala?Ser?Tyr?Leu?Asn?Asp?Ser?Asp

20 25 30

Pro?Glu?Glu?Thr?Asn?Glu?Trp?Met?Asp?Ser?Leu?Asp?Gly?Leu?Leu?Gln

35 40 45

Glu?Ser?Ser?Pro?Glu?Arg?Ala?Arg?Tyr?Leu?Met?Leu?Arg?Leu?Leu?Glu

50 55 60

Arg?Ala?Ser?Ala?Lys?Arg?Val?Ser?Leu?Pro?Pro?Met?Thr?Ser?Thr?Asp

65 70 75 80

Tyr?Val?Asn?Thr?Ile?Pro?Thr?Ser?Met?Glu?Pro?Glu?Phe?Pro?Gly?Asp

85 90 95

Glu?Glu?Met?Glu?Lys?Arg?Tyr?Arg?Arg?Trp?Ile?Arg?Trp?Asn?Ala?Ala

100 105 110

Ile?Met?Val?His?Arg?Ala?Gln?Arg?Pro?Gly?Ile?Gly?Val?Gly?Gly?His

115 120 125

Ile?Ser?Thr?Tyr?Ala?Gly?Ala?Ala

130 135

<210>99

<211>508

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(508)

<223>FRXA02887

<400>99

ttcgtgcact?tcggcgtgcc?acaattaggt?acgaccaaga?atgggaccgg?gaaaccggga?60

cgtataaacg?aaataaaaca?ttccaacagg?aggtgtggaa?atg?gcc?gat?caa?gca 115

Met?Ala?Asp?Gln?Ala

1 5

aaa?ctt?ggt?ggc?aag?ccc?tcg?gat?gac?tct?aac?ttc?gcg?atg?atc?cgc 163

Lys?Leu?Gly?Gly?Lys?Pro?Ser?Asp?Asp?Ser?Asn?Phe?Ala?Met?Ile?Arg

10 15 20

gat?ggc?gtg?gca?tct?tat?ttg?aac?gac?tca?gat?ccg?gag?gag?acc?aac 211

Asp?Gly?Val?Ala?Ser?Tyr?Leu?Asn?Asp?Ser?Asp?Pro?Glu?Glu?Thr?Asn

25 30 35

gag?tgg?atg?gat?tca?ctc?gac?gga?tta?ctc?cag?gag?tct?tct?cca?gaa 259

Glu?Trp?Met?Asp?Ser?Leu?Asp?Gly?Leu?Leu?Gln?Glu?Ser?Ser?Pro?Glu

40 45 50

cgt?gct?cgt?tac?ctc?atg?ctt?cgt?ttg?ctt?gag?cgt?gca?tct?gca?aag 307

Arg?Ala?Arg?Tyr?Leu?Met?Leu?Arg?Leu?Leu?Glu?Arg?Ala?Ser?Ala?Lys

55 60 65

cgc?gta?tct?ctt?ccc?cca?atg?acg?tca?acc?gac?tac?gtc?aac?acc?att 355

Arg?Val?Ser?Leu?Pro?Pro?Met?Thr?Ser?Thr?Asp?Tyr?Val?Asn?Thr?Ile

70 75 80 85

cca?acc?tct?atg?gaa?cct?gaa?ttc?cca?ggc?gat?gag?gaa?atg?gag?aag 403

Pro?Thr?Ser?Met?Glu?Pro?Glu?Phe?Pro?Gly?Asp?Glu?Glu?Met?Glu?Lys

90 95 100

cgt?tac?cgt?cgt?tgg?att?cgc?tgg?aac?gca?gcc?atc?atg?gtt?cac?cgc 451

Arg?Tyr?Arg?Arg?Trp?Ile?Arg?Trp?Asn?Ala?Ala?Ile?Met?Val?His?Arg

105 110 115

gct?cag?cga?cca?ggc?atc?ggc?gtc?ggc?gga?cac?att?tcc?act?tac?gca 499

Ala?Gln?Arg?Pro?Gly?Ile?Gly?Val?Gly?Gly?His?Ile?Ser?Thr?Tyr?Ala

120 125 130

ggc?gca?gcc 508

Gly?Ala?Ala

135

<210>100

<211>136

<212>PRT

＜213〉Corynebacterium glutamicum

<400>100

Met?Ala?Asp?Gln?Ala?Lys?Leu?Gly?Gly?Lys?Pro?Ser?Asp?Asp?Ser?Asn

1 5 10 15

Phe?Ala?Met?Ile?Arg?Asp?Gly?Val?Ala?Ser?Tyr?Leu?Asn?Asp?Ser?Asp

20 25 30

Pro?Glu?Glu?Thr?Asn?Glu?Trp?Met?Asp?Ser?Leu?Asp?Gly?Leu?Leu?Gln

35 40 45

Glu?Ser?Ser?Pro?Glu?Arg?Ala?Arg?Tyr?Leu?Met?Leu?Arg?Leu?Leu?Glu

50 55 60

Arg?Ala?Ser?Ala?Lys?Arg?Val?Ser?Leu?Pro?Pro?Met?Thr?Ser?Thr?Asp

65 70 75 80

Tyr?Val?Asn?Thr?Ile?Pro?Thr?Ser?Met?Glu?Pro?Glu?Phe?Pro?Gly?Asp

85 90 95

Glu?Glu?Met?Glu?Lys?Arg?Tyr?Arg?Arg?Trp?Ile?Arg?Trp?Asn?Ala?Ala

100 105 110

Ile?Met?Val?His?Arg?Ala?Gln?Arg?Pro?Gly?Ile?Gly?Val?Gly?Gly?His

115 120 125

Ile?Ser?Thr?Tyr?Ala?Gly?Ala?Ala

130 135

<210>101

<211>1385

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(1362)

<223>RXN03043

<400>101

gat?ctc?gat?ggc?ttc?cgt?cag?gaa?gtt?tcc?cgt?gag?cag?ggt?ggc?att 48

Asp?Leu?Asp?Gly?Phe?Arg?Gln?Glu?Val?Ser?Arg?Glu?Gln?Gly?Gly?Ile

1 5 10 15

ccg?tcc?tac?cct?cac?cca?cac?ggt?atg?aag?gac?ttc?tgg?gag?ttc?cca 96

Pro?Ser?Tyr?Pro?His?Pro?His?Gly?Met?Lys?Asp?Phe?Trp?Glu?Phe?Pro

20 25 30

act?gtg?tcc?atg?ggt?ctt?ggc?cca?atg?gat?gcc?att?tac?cag?gca?cgt 144

Thr?Val?Ser?Met?Gly?Leu?Gly?Pro?Met?Asp?Ala?Ile?Tyr?Gln?Ala?Arg

35 40 45

ttc?aac?cgc?tac?ctc?gaa?aac?cgt?ggc?atc?aag?gac?acc?tct?gac?cag 192

Phe?Asn?Arg?Tyr?Leu?Glu?Asn?Arg?Gly?Ile?Lys?Asp?Thr?Ser?Asp?Gln

50 55 60

cac?gtc?tgg?gcc?ttc?ctt?ggc?gac?ggc?gaa?atg?gac?gag?cca?gaa?tca 240

His?Val?Trp?Ala?Phe?Leu?Gly?Asp?Gly?Glu?Met?Asp?Glu?Pro?Glu?Ser

65 70 75 80

cgt?ggt?ctc?ate?cag?cag?gct?gca?ctg?aac?aac?ctg?gac?aac?ctg?acc 288

Arg?Gly?Leu?Ile?Gln?Gln?Ala?Ala?Leu?Asn?Asn?Leu?Asp?Asn?Leu?Thr

85 90 95

ttc?gtg?gtt?aac?tgc?aac?ctg?cag?cgt?ctc?gac?gga?cct?gtc?cgc?ggt 336

Phe?Val?Val?Asn?Cys?Asn?Leu?Gln?Arg?Leu?Asp?Gly?Pro?Val?Arg?Gly

100 105 110

aac?acc?aag?atc?atc?cag?gaa?ctc?gag?tcc?ttc?ttc?cgt?ggc?gca?ggc 384

Asn?Thr?Lys?Ile?Ile?Gln?Glu?Leu?Glu?Ser?Phe?Phe?Arg?Gly?Ala?Gly

115 120 125

tgg?tct?gtg?atc?aag?gtt?gtt?tgg?ggt?cgc?gag?tgg?gat?gaa?ctt?ctg 432

Trp?Ser?Val?Ile?Lys?Val?Val?Trp?Gly?Arg?Glu?Trp?Asp?Glu?Leu?Leu

130 135 140

gag?aag?gac?cag?gat?ggt?gca?ctt?gtt?gag?atc?atg?aac?aac?acc?tcc 480

Glu?Lys?Asp?Gln?Asp?Gly?Ala?Leu?Val?Glu?Ile?Met?Asn?Asn?Thr?Ser

145 150 155 160

gat?ggt?gac?tac?cag?acc?ttc?aag?gct?aac?gac?ggc?gca?tat?gtt?cgt 528

Asp?Gly?Asp?Tyr?Gln?Thr?Phe?Lys?Ala?Asn?Asp?Gly?Ala?Tyr?Val?Arg

165 170 175

gag?cac?ttc?ttc?gga?cgt?gac?cca?cgc?acc?gca?aag?ctc?gtt?gag?aac 576

Glu?His?Phe?Phe?Gly?Arg?Asp?Pro?Arg?Thr?Ala?Lys?Leu?Val?Glu?Asn

180 185 190

atg?acc?gac?gaa?gaa?atc?tgg?aag?ctt?cca?cgt?ggc?ggc?cac?gat?tac 624

Met?Thr?Asp?Glu?Glu?Ile?Trp?Lys?Leu?Pro?Arg?Gly?Gly?His?Asp?Tyr

195 200 205

cgc?aag?gtt?tac?gca?gcc?tac?aag?cga?gct?ctt?gag?acc?aag?gat?cgc 672

Arg?Lys?Val?Tyr?Ala?Ala?Tyr?Lys?Arg?Ala?Leu?Glu?Thr?Lys?Asp?Arg

210 215 220

cca?acc?gtc?atc?ctt?gct?cac?acc?att?aag?ggc?tac?gga?ctc?ggc?cac 720

Pro?Thr?Val?Ile?Leu?Ala?His?Thr?Ile?Lys?Gly?Tyr?Gly?Leu?Gly?His

225 230 235 240

aac?ttc?gaa?ggc?cgt?aac?gca?acc?cac?cag?atg?aag?aag?ctg?acg?ctt 768

Asn?Phe?Glu?Gly?Arg?Asn?Ala?Thr?His?Gln?Met?Lys?Lys?Leu?Thr?Leu

245 250 255

gat?gat?ctg?aag?ttg?ttc?cgc?gac?aag?cag?ggc?atc?cca?atc?acc?gat 816

Asp?Asp?Leu?Lys?Leu?Phe?Arg?Asp?Lys?Gln?Gly?Ile?Pro?Ile?Thr?Asp

260 265 270

gag?cag?ctg?gag?aag?gat?cct?tac?ctt?cct?cct?tac?tac?cac?cca?ggt 864

Glu?Gln?Leu?Glu?Lys?Asp?Pro?Tyr?Leu?Pro?Pro?Tyr?Tyr?His?Pro?Gly

275 280 285

gaa?gac?gct?cct?gaa?atc?aag?tac?atg?aag?gaa?cgt?cgc?gca?gcg?ctc 912

Glu?Asp?Ala?Pro?Glu?Ile?Lys?Tyr?Met?Lys?Glu?Arg?Arg?Ala?Ala?Leu

290 295 300

ggt?ggc?tac?ctg?cca?gag?cgt?cgt?gag?aac?tac?gat?cca?att?cag?gtt 960

Gly?Gly?Tyr?Leu?Pro?Glu?Arg?Arg?Glu?Asn?Tyr?Asp?Pro?Ile?Gln?Val

305 310 315 320

cca?cca?ctg?gat?aag?ctt?cgc?tct?gtc?cgt?aag?ggc?tcc?ggc?aag?cag 1008

Pro?Pro?Leu?Asp?Lys?Leu?Arg?Ser?Val?Arg?Lys?Gly?Ser?Gly?Lys?Gln

325 330 335

cag?atc?gct?acc?acc?atg?gcg?act?gtt?cgt?acc?ttc?aag?gaa?ctg?atg 1056

Gln?Ile?Ala?Thr?Thr?Met?Ala?Thr?Val?Arg?Thr?Phe?Lys?Glu?Leu?Met

340 345 350

cgc?gat?aag?ggc?ttg?gct?gat?cgc?ctt?gtc?cca?atc?att?cct?gat?gag 1104

Arg?Asp?Lys?Gly?Leu?Ala?Asp?Arg?Leu?Val?Pro?Ile?Ile?Pro?Asp?Glu

355 360 365

gca?cgt?acc?ttc?ggt?ctt?gac?tct?tgg?ttc?cca?acc?ttg?aag?atc?tac 1152

Ala?Arg?Thr?Phe?Gly?Leu?Asp?Ser?Trp?Phe?Pro?Thr?Leu?Lys?Ile?Tyr

370 375 380

aac?ccg?cac?ggt?cag?aac?tac?gtg?cct?gtt?gac?cac?gac?ctg?atg?ctc 1200

Asn?Pro?His?Gly?Gln?Asn?Tyr?Val?Pro?Val?Asp?His?Asp?Leu?Met?Leu

385 390 395 400

tcc?tac?cgt?gag?gca?cct?gaa?gga?cag?atc?ctg?cac?gaa?ggc?atc?aac 1248

Ser?Tyr?Arg?Glu?Ala?Pro?Glu?Gly?Gln?Ile?Leu?His?Glu?Gly?Ile?Asn

405 410 415

gag?gct?ggt?tcc?gtg?gca?tcg?ttc?atc?gct?gcg?ggt?acc?tcc?tac?gcc 1296

Glu?Ala?Gly?Ser?Val?Ala?Ser?Phe?Ile?Ala?Ala?Gly?Thr?Ser?Tyr?Ala

420 425 430

acc?cac?ggc?aag?gcc?atg?att?ccg?ctg?tac?atc?ttc?tac?tcg?atg?ttc 1344

Thr?His?Gly?Lys?Ala?Met?Ile?Pro?Leu?Tyr?Ile?Phe?Tyr?Ser?Met?Phe

435 440 445

ggg?att?cca?gcg?cac?cgg?tgactccatc?tgggcagcag?ccg 1385

Gly?Ile?Pro?Ala?His?Arg

450

<210>102

<211>454

<212>PRT

＜213〉Corynebacterium glutamicum

<400>102

Asp?Leu?Asp?Gly?Phe?Arg?Gln?Glu?Val?Ser?Arg?Glu?Gln?Gly?Gly?Ile

1 5 10 15

Pro?Ser?Tyr?Pro?His?Pro?His?Gly?Met?Lys?Asp?Phe?Trp?Glu?Phe?Pro

20 25 30

Thr?Val?Ser?Met?Gly?Leu?Gly?Pro?Met?Asp?Ala?Ile?Tyr?Gln?Ala?Arg

35 40 45

Phe?Asn?Arg?Tyr?Leu?Glu?Asn?Arg?Gly?Ile?Lys?Asp?Thr?Ser?Asp?Gln

50 55 60

His?Val?Trp?Ala?Phe?Leu?Gly?Asp?Gly?Glu?Met?Asp?Glu?Pro?Glu?Ser

65 70 75 80

Arg?Gly?Leu?Ile?Gln?Gln?Ala?Ala?Leu?Asn?Asn?Leu?Asp?Asn?Leu?Thr

85 90 95

Phe?Val?Val?Asn?Cys?Asn?Leu?Gln?Arg?Leu?Asp?Gly?Pro?Val?Arg?Gly

100 105 110

Asn?Thr?Lys?Ile?Ile?Gln?Glu?Leu?Glu?Ser?Phe?Phe?Arg?Gly?Ala?Gly

115 120 125

Trp?Ser?Val?Ile?Lys?Val?Val?Trp?Gly?Arg?Glu?Trp?Asp?Glu?Leu?Leu

130 135 140

Glu?Lys?Asp?Gln?Asp?Gly?Ala?Leu?Val?Glu?Ile?Met?Asn?Asn?Thr?Ser

145 150 155 160

Asp?Gly?Asp?Tyr?Gln?Thr?Phe?Lys?Ala?Asn?Asp?Gly?Ala?Tyr?Val?Arg

165 170 175

Glu?His?Phe?Phe?Gly?Arg?Asp?Pro?Arg?Thr?Ala?Lys?Leu?Val?Glu?Asn

180 185 190

Met?Thr?Asp?Glu?Glu?Ile?Trp?Lys?Leu?Pro?Arg?Gly?Gly?His?Asp?Tyr

195 200 205

Arg?Lys?Val?Tyr?Ala?Ala?Tyr?Lys?Arg?Ala?Leu?Glu?Thr?Lys?Asp?Arg

210 215 220

Pro?Thr?Val?Ile?Leu?Ala?His?Thr?Ile?Lys?Gly?Tyr?Gly?Leu?Gly?His

225 230 235 240

Asn?Phe?Glu?Gly?Arg?Asn?Ala?Thr?His?Gln?Met?Lys?Lys?Leu?Thr?Leu

245 250 255

Asp?Asp?Leu?Lys?Leu?Phe?Arg?Asp?Lys?Gln?Gly?Ile?Pro?Ile?Thr?Asp

260 265 270

Glu?Gln?Leu?Glu?Lys?Asp?Pro?Tyr?Leu?Pro?Pro?Tyr?Tyr?His?Pro?Gly

275 280 285

Glu?Asp?Ala?Pro?Glu?Ile?Lys?Tyr?Met?Lys?Glu?Arg?Arg?Ala?Ala?Leu

290 295 300

Gly?Gly?Tyr?Leu?Pro?Glu?Arg?Arg?Glu?Asn?Tyr?Asp?Pro?Ile?Gln?Val

305 310 315 320

Pro?Pro?Leu?Asp?Lys?Leu?Arg?Ser?Val?Arg?Lys?Gly?Ser?Gly?Lys?Gln

325 330 335

Gln?Ile?Ala?Thr?Thr?Met?Ala?Thr?Val?Arg?Thr?Phe?Lys?Glu?Leu?Met

340 345 350

Arg?Asp?Lys?Gly?Leu?Ala?Asp?Arg?Leu?Val?Pro?Ile?Ile?Pro?Asp?Glu

355 360 365

Ala?Arg?Thr?Phe?Gly?Leu?Asp?Ser?Trp?Phe?Pro?Thr?Leu?Lys?Ile?Tyr

370 375 380

Asn?Pro?His?Gly?Gln?Asn?Tyr?Val?Pro?Val?Asp?His?Asp?Leu?Met?Leu

385 390 395 400

Ser?Tyr?Arg?Glu?Ala?Pro?Glu?Gly?Gln?Ile?Leu?His?Glu?Gly?Ile?Asn

405 410 415

Glu?Ala?Gly?Ser?Val?Ala?Ser?Phe?Ile?Ala?Ala?Gly?Thr?Ser?Tyr?Ala

420 425 430

Thr?His?Gly?Lys?Ala?Met?Ile?Pro?Leu?Tyr?Ile?Phe?Tyr?Ser?Met?Phe

435 440 445

Gly?Ile?Pro?Ala?His?Arg

450

<210>103

<211>1287

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(1287)

<223>FRXA02897

<400>103

gat?ctc?gat?ggc?ttc?cgt?cag?gaa?gtt?tcc?cgt?gag?cag?ggt?ggc?att 48

Asp?Leu?Asp?Gly?Phe?Arg?Gln?Glu?Val?Ser?Arg?Glu?Gln?Gly?Gly?Ile

1 5 10 15

ccg?tcc?tac?cct?cac?cca?cac?ggt?atg?aag?gac?ttc?tgg?gag?ttc?cca 96

Pro?Ser?Tyr?Pro?His?Pro?His?Gly?Met?Lys?Asp?Phe?Trp?Glu?Phe?Pro

20 25 30

act?gtg?tcc?atg?ggt?ctt?ggc?cca?atg?gat?gcc?att?tac?cag?gca?cgt 144

Thr?Val?Ser?Met?Gly?Leu?Gly?Pro?Met?Asp?Ala?Ile?Tyr?Gln?Ala?Arg

35 40 45

ttc?aac?cgc?tac?ctc?gaa?aac?cgt?ggc?atc?aag?gac?acc?tct?gac?cag 192

Phe?Asn?Arg?Tyr?Leu?Glu?Asn?Arg?Gly?Ile?Lys?Asp?Thr?Ser?Asp?Gln

50 55 60

cac?gtc?tgg?gcc?ttc?ctt?ggc?gac?ggc?gaa?atg?gac?gag?cca?gaa?tca 240

His?Val?Trp?Ala?Phe?Leu?Gly?Asp?Gly?Glu?Met?Asp?Glu?Pro?Glu?Ser

65 70 75 80

cgt?ggt?ctc?atc?cag?cag?gct?gca?ctg?aac?aac?ctg?gac?aac?ctg?acc 288

Arg?Gly?Leu?Ile?Gln?Gln?Ala?Ala?Leu?Asn?Asn?Leu?Asp?Asn?Leu?Thr

85 90 95

ttc?gtg?gtt?aac?tgc?aac?ctg?cag?cgt?ctc?gac?gga?cct?gtc?cgc?ggt 336

Phe?Val?Val?Asn?Cys?Asn?Leu?Gln?Arg?Leu?Asp?Gly?Pro?Val?Arg?Gly

100 105 110

aac?acc?aag?atc?atc?cag?gaa?ctc?gag?tcc?ttc?ttc?cgt?ggc?gca?ggc 384

Asn?Thr?Lys?Ile?Ile?Gln?Glu?Leu?Glu?Ser?Phe?Phe?Arg?Gly?Ala?Gly

115 120 125

tgg?tct?gtg?atc?aag?gtt?gtt?tgg?ggt?cgc?gag?tgg?gat?gaa?ctt?ctg 432

Trp?Ser?Val?Ile?Lys?Val?Val?Trp?Gly?Arg?Glu?Trp?Asp?Glu?Leu?Leu

130 135 140

gag?aag?gac?cag?gat?ggt?gca?ctt?gtt?gag?atc?atg?aac?aac?acc?tcc 480

Glu?Lys?Asp?Gln?Asp?Gly?Ala?Leu?Val?Glu?Ile?Met?Asn?Asn?Thr?Ser

145 150 155 160

gat?ggt?gac?tac?cag?acc?ttc?aag?gct?aac?gac?ggc?gca?tat?gtt?cgt 528

Asp?Gly?Asp?Tyr?Gln?Thr?Phe?Lys?Ala?Asn?Asp?Gly?Ala?Tyr?Val?Arg

165 170 175

gag?cac?ttc?ttc?gga?cgt?gac?cca?cgc?acc?gca?aag?ctc?gtt?gag?aac 576

Glu?His?Phe?Phe?Gly?Arg?Asp?Pro?Arg?Thr?Ala?Lys?Leu?Val?Glu?Asn

180 185 190

atg?acc?gac?gaa?gaa?atc?tgg?aag?ctt?cca?cgt?ggc?ggc?cac?gat?tac 624

Met?Thr?Asp?Glu?Glu?Ile?Trp?Lys?Leu?Pro?Arg?Gly?Gly?His?Asp?Tyr

195 200 205

cgc?aag?gtt?tac?gca?gcc?tac?aag?cga?gct?ctt?gag?acc?aag?gat?cgc 672

Arg?Lys?Val?Tyr?Ala?Ala?Tyr?Lys?Arg?Ala?Leu?Glu?Thr?Lys?Asp?Arg

210 215 220

cca?acc?gtc?atc?ctt?gct?cac?acc?att?aag?ggc?tac?gga?ctc?ggc?cac 720

Pro?Thr?Val?Ile?Leu?Ala?His?Thr?Ile?Lys?Gly?Tyr?Gly?Leu?Gly?His

225 230 235 240

aac?ttc?gaa?ggc?cgt?aac?gca?acc?cac?cag?atg?aag?aag?ctg?acg?ctt 768

Asn?Phe?Glu?Gly?Arg?Asn?Ala?Thr?His?Gln?Met?Lys?Lys?Leu?Thr?Leu

245 250 255

gat?gat?ctg?aag?ttg?ttc?cgc?gac?aag?cag?ggc?atc?cca?atc?acc?gat 816

Asp?Asp?Leu?Lys?Leu?Phe?Arg?Asp?Lys?Gln?Gly?Ile?Pro?Ile?Thr?Asp

260 265 270

gag?cag?ctg?gag?aag?gat?cct?tac?ctt?cct?cct?tac?tac?cac?cca?ggt 864

Glu?Gln?Leu?Glu?Lys?Asp?Pro?Tyr?Leu?Pro?Pro?Tyr?Tyr?His?Pro?Gly

275 280 285

gaa?gac?gct?cct?gaa?atc?aag?tac?atg?aag?gaa?cgt?cgc?gca?gcg?ctc 912

Glu?Asp?Ala?Pro?Glu?Ile?Lys?Tyr?Met?Lys?Glu?Arg?Arg?Ala?Ala?Leu

290 295 300

ggt?ggc?tac?ctg?cca?gag?cgt?cgt?gag?aac?tac?gat?cca?att?cag?gtt 960

Gly?Gly?Tyr?Leu?Pro?Glu?Arg?Arg?Glu?Asn?Tyr?Asp?Pro?Ile?Gln?Val

305 310 315 320

cca?cca?ctg?gat?aag?ctt?cgc?tct?gtc?cgt?aag?ggc?tcc?ggc?aag?cag 1008

Pro?Pro?Leu?Asp?Lys?Leu?Arg?Ser?Val?Arg?Lys?Gly?Ser?Gly?Lys?Gln

325 330 335

cag?atc?gct?acc?acc?atg?gcg?act?gtt?cgt?acc?ttc?aag?gaa?ctg?atg 1056

Gln?Ile?Ala?Thr?Thr?Met?Ala?Thr?Val?Arg?Thr?Phe?Lys?Glu?Leu?Met

340 345 350

cgc?gat?aag?ggc?ttg?gct?gat?cgc?ctt?gtc?cca?atc?att?cct?gat?gag 1104

Arg?Asp?Lys?Gly?Leu?Ala?Asp?Arg?Leu?Val?Pro?Ile?Ile?Pro?Asp?Glu

355 360 365

gca?cgt?acc?ttc?ggt?ctt?gac?tct?tgg?ttc?cca?acc?ttg?aag?atc?tac 1152

Ala?Arg?Thr?Phe?Gly?Leu?Asp?Ser?Trp?Phe?Pro?Thr?Leu?Lys?Ile?Tyr

370 375 380

aac?ccg?cac?ggt?cag?aac?tac?gtg?cct?gtt?gac?cac?gac?ctg?atg?ctc 1200

Asn?Pro?His?Gly?Gln?Asn?Tyr?Val?Pro?Val?Asp?His?Asp?Leu?Met?Leu

385 390 395 400

tcc?tac?cgt?gag?gca?cct?gaa?gga?cag?atc?ctg?cac?gaa?ggc?atc?aac 1248

Ser?Tyr?Arg?Glu?Ala?Pro?Glu?Gly?Gln?Ile?Leu?His?Glu?Gly?Ile?Asn

405 410 415

gag?gct?ggt?tcc?gtg?gca?tcg?ttc?atc?gct?gcg?ggt?acc 1287

Glu?Ala?Gly?Ser?Val?Ala?Ser?Phe?Ile?Ala?Ala?Gly?Thr

420 425

<210>104

<211>429

<212>PRT

＜213〉Corynebacterium glutamicum

<400>104

Asp?Leu?Asp?Gly?Phe?Arg?Gln?Glu?Val?Ser?Arg?Glu?Gln?Gly?Gly?Ile

1 5 10 15

Pro?Ser?Tyr?Pro?His?Pro?His?Gly?Met?Lys?Asp?Phe?Trp?Glu?Phe?Pro

20 25 30

Thr?Val?Ser?Met?Gly?Leu?Gly?Pro?Met?Asp?Ala?Ile?Tyr?Gln?Ala?Arg

35 40 45

Phe?Asn?Arg?Tyr?Leu?Glu?Asn?Arg?Gly?Ile?Lys?Asp?Thr?Ser?Asp?Gln

50 55 60

His?Val?Trp?Ala?Phe?Leu?Gly?Asp?Gly?Glu?Met?Asp?Glu?Pro?Glu?Ser

65 70 75 80

Arg?Gly?Leu?Ile?Gln?Gln?Ala?Ala?Leu?Asn?Asn?Leu?Asp?Asn?Leu?Thr

85 90 95

Phe?Val?Val?Asn?Cys?Asn?Leu?Gln?Arg?Leu?Asp?Gly?Pro?Val?Arg?Gly

100 105 110

Asn?Thr?Lys?Ile?Ile?Gln?Glu?Leu?Glu?Ser?Phe?Phe?Arg?Gly?Ala?Gly

115 120 125

Trp?Ser?Val?Ile?Lys?Val?Val?Trp?Gly?Arg?Glu?Trp?Asp?Glu?Leu?Leu

130 135 140

Glu?Lys?Asp?Gln?Asp?Gly?Ala?Leu?Val?Glu?Ile?Met?Asn?Asn?Thr?Ser

145 150 155 160

Asp?Gly?Asp?Tyr?Gln?Thr?Phe?Lys?Ala?Asn?Asp?Gly?Ala?Tyr?Val?Arg

165 170 175

Glu?His?Phe?Phe?Gly?Arg?Asp?Pro?Arg?Thr?Ala?Lys?Leu?Val?Glu?Asn

180 185 190

Met?Thr?Asp?Glu?Glu?Ile?Trp?Lys?Leu?Pro?Arg?Gly?Gly?His?Asp?Tyr

195 200 205

Arg?Lys?Val?Tyr?Ala?Ala?Tyr?Lys?Arg?Ala?Leu?Glu?Thr?Lys?Asp?Arg

210 215 220

Pro?Thr?Val?Ile?Leu?Ala?His?Thr?Ile?Lys?Gly?Tyr?Gly?Leu?Gly?His

225 230 235 240

Asn?Phe?Glu?Gly?Arg?Asn?Ala?Thr?His?Gln?Met?Lys?Lys?Leu?Thr?Leu

245 250 255

Asp?Asp?Leu?Lys?Leu?Phe?Arg?Asp?Lys?Gln?Gly?Ile?Pro?Ile?Thr?Asp

260 265 270

Glu?Gln?Leu?Glu?Lys?Asp?Pro?Tyr?Leu?Pro?Pro?Tyr?Tyr?His?Pro?Gly

275 280 285

Glu?Asp?Ala?Pro?Glu?Ile?Lys?Tyr?Met?Lys?Glu?Arg?Arg?Ala?Ala?Leu

290 295 300

Gly?Gly?Tyr?Leu?Pro?Glu?Arg?Arg?Glu?Asn?Tyr?Asp?Pro?Ile?Gln?Val

305 310 315 320

Pro?Pro?Leu?Asp?Lys?Leu?Arg?Ser?Val?Arg?Lys?Gly?Ser?Gly?Lys?Gln

325 330 335

Gln?Ile?Ala?Thr?Thr?Met?Ala?Thr?Val?Arg?Thr?Phe?Lys?Glu?Leu?Met

340 345 350

Arg?Asp?Lys?Gly?Leu?Ala?Asp?Arg?Leu?Val?Pro?Ile?Ile?Pro?Asp?Glu

355 360 365

Ala?Arg?Thr?Phe?Gly?Leu?Asp?Ser?Trp?Phe?Pro?Thr?Leu?Lys?Ile?Tyr

370 375 380

Asn?Pro?His?Gly?Gln?Asn?Tyr?Val?Pro?Val?Asp?His?Asp?Leu?Met?Leu

385 390 395 400

Ser?Tyr?Arg?Glu?Ala?Pro?Glu?Gly?Gln?Ile?Leu?His?Glu?Gly?Ile?Asn

405 410 415

Glu?Ala?Gly?Ser?Val?Ala?Ser?Phe?Ile?Ala?Ala?Gly?Thr

420 425

<210>105

<211>1133

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(88)..(1110)

<223>RXN03083

<400>105

attcagcagt?aatcatttag?acttggaacc?gcttaccagt?ggtttcaaca?atgcattcac?60

ccagctcaca?cgtgtggagg?tgcctta?atg?gca?aag?agg?atc?gta?att?atc?ggc?114

Met?Ala?Lys?Arg?Ile?Val?Ile?Ile?Gly

1 5

ggt?gga?cct?gca?ggc?tat?gaa?gcc?gca?ctc?gca?ggc?gct?aaa?tac?ggt 162

Gly?Gly?Pro?Ala?Gly?Tyr?Glu?Ala?Ala?Leu?Ala?Gly?Ala?Lys?Tyr?Gly

10 15 20 25

gca?gaa?gtt?acc?gtt?att?gaa?gat?gtc?gga?gtt?ggc?gga?tcc?gca?gtc 210

Ala?Glu?Val?Thr?Val?Ile?Glu?Asp?Val?Gly?Val?Gly?Gly?Ser?Ala?Val

30 35 40

acc?atg?gac?tgt?gta?cct?tca?aag?tcc?ttc?atc?gct?ggt?acc?ggt?atc 258

Thr?Met?Asp?Cys?Val?Pro?Ser?Lys?Ser?Phe?Ile?Ala?Gly?Thr?Gly?Ile

45 50 55

aaa?acc?gac?ctc?cga?cgt?gct?gat?gac?atg?gga?ctt?aac?cgt?ggg?ctt 306

Lys?Thr?Asp?Leu?Arg?Arg?Ala?Asp?Asp?Met?Gly?Leu?Asn?Arg?Gly?Leu

60 65 70

gga?aaa?gca?cac?cta?gaa?atc?gat?gca?ctg?aac?atc?cgt?gtg?aag?gac 354

Gly?Lys?Ala?His?Leu?Glu?Ile?Asp?Ala?Leu?Asn?Ile?Arg?ValLys?Asp

75 80 85

ctt?gcg?aaa?gca?cag?tcc?gaa?gat?atc?ttg?ggc?cag?ctg?cag?cgc?tca 402

Leu?Ala?Lys?Ala?Gln?Ser?Glu?Asp?Ile?Leu?Gly?Gln?Leu?Gln?Arg?Ser

90 95 100 105

gat?gtc?cgc?atg?att?aac?ggt?gtg?ggc?cgc?ttt?gat?gat?tac?aac?acc 450

Asp?Val?Arg?Met?Ile?Asn?Gly?Val?Gly?Arg?Phe?Asp?Asp?Tyr?Asn?Thr

110 115 120

aag?caa?acc?acc?cac?tac?att?aaa?gtc?acc?cac?agc?gat?ggc?tcc?gaa 498

Lys?Gln?Thr?Thr?His?Tyr?Ile?Lys?Val?Thr?His?Ser?Asp?Gly?Ser?Glu

125 130 135

gaa?acc?gtt?gag?tgc?gat?ctg?gtg?ctg?gtt?gca?act?ggt?gca?acc?ccc 546

Glu?Thr?Val?Glu?Cys?Asp?Leu?Val?Leu?Val?Ala?Thr?Gly?Ala?Thr?Pro

140 145 150

cgc?att?ctt?aaa?ggt?gca?gag?cca?gac?ggc?gag?cgc?atc?ttg?acc?tgg 594

Arg?Ile?Leu?Lys?Gly?Ala?Glu?Pro?Asp?Gly?Glu?Arg?Ile?Leu?Thr?Trp

155 160 165

cgt?cag?gtc?tac?gac?att?gaa?gaa?ctc?ccc?acc?cac?ctt?atc?gtg?gtt 642

Arg?Gln?Val?Tyr?Asp?Ile?Glu?Glu?Leu?Pro?Thr?His?Leu?Ile?Val?Val

170 175 180 185

ggt?tcc?ggt?gtg?acc?ggt?gcg?gaa?ttt?gtc?tct?gcg?ttt?gct?gaa?ctc 690

Gly?Ser?Gly?Val?Thr?Gly?Ala?Glu?Phe?Val?Ser?Ala?Phe?Ala?Glu?Leu

190 195 200

ggc?gtc?aaa?gtc?acc?atg?gtg?gca?tcc?cgt?gac?cgc?att?ttg?cct?cac 738

Gly?Val?Lys?Val?Thr?Met?Val?Ala?Ser?Arg?Asp?Arg?Ile?Leu?Pro?His

205 210 215

gat?gac?gca?gat?gcc?gca?gac?gtg?ctg?gaa?acc?gtt?ctg?gct?gag?cgc 786

Asp?Asp?Ala?Asp?Ala?Ala?Asp?Val?Leu?Glu?Thr?Val?Leu?Ala?Glu?Arg

220 225 230

gga?gta?tcc?ctg?gaa?aag?cat?gcc?cgc?gtg?gag?tct?gtc?acc?cgc?acc 834

Gly?Val?Ser?Leu?Glu?Lys?His?Ala?Arg?Val?Glu?Ser?Val?Thr?Arg?Thr

235 240 245

gaa?gac?ggt?ggc?gtg?tgt?gtt?cgc?act?gct?gac?gga?cga?gaa?atc?tac 882

Glu?Asp?Gly?Gly?Val?Cys?Val?Arg?Thr?Ala?Asp?Gly?Arg?Glu?Ile?Tyr

250 255 260 265

ggt?tct?cac?gcg?ttg?atg?act?gtt?ggt?tcc?att?cca?aac?acg?gca?gat 930

Gly?Ser?His?Ala?Leu?Met?Thr?Val?Gly?Ser?Ile?Pro?Asn?Thr?Ala?Asp

270 275 280

ctt?ggc?ctg?gag?aac?atc?ggt?gtt?gag?ctg?gca?cca?tcc?ggc?cat?atc 978

Leu?Gly?Leu?Glu?Asn?Ile?Gly?Val?Glu?Leu?Ala?Pro?Ser?Gly?His?Ile

285 290 295

aag?gtt?gac?cgg?tct?ccc?gca?cca?aca?tcc?ccg?gtg?tgt?acg?cag?cag 1026

Lys?Val?Asp?Arg?Ser?Pro?Ala?Pro?Thr?Ser?Pro?Val?Cys?Thr?Gln?Gln

300 305 310

gtg?act?gta?ctg?acc?tat?tcc?cac?tgg?cgt?ccg?ttg?cag?cga?tgc?agg 1074

Val?Thr?Val?Leu?Thr?Tyr?Ser?His?Trp?Arg?Pro?Leu?Gln?Arg?Cys?Arg

315 320 325

gcc?gta?tcg?cca?tgt?atc?acg?cac?tcg?gtg?aag?gcg?tgagccccat 1120

Ala?Val?Ser?Pro?Cys?Ile?Thr?His?Ser?Val?Lys?Ala

330 335 340

ccgtttgaag?act 1133

<210>106

<211>341

<212>PRT

＜213〉Corynebacterium glutamicum

<400>106

Met?Ala?Lys?Arg?Ile?Val?Ile?Ile?Gly?Gly?Gly?Pro?Ala?Gly?Tyr?Glu

1 5 10 15

Ala?Ala?Leu?Ala?Gly?Ala?Lys?Tyr?Gly?Ala?Glu?Val?Thr?Val?Ile?Glu

20 25 30

Asp?Val?Gly?Val?Gly?Gly?Ser?Ala?Val?Thr?Met?Asp?Cys?Val?Pro?Ser

35 40 45

Lys?Ser?Phe?Ile?Ala?Gly?Thr?Gly?Ile?Lys?Thr?Asp?Leu?Arg?Arg?Ala

50 55 60

Asp?Asp?Met?Gly?Leu?Asn?Arg?Gly?Leu?Gly?Lys?Ala?His?Leu?Glu?Ile

65 70 75 80

Asp?Ala?Leu?Asn?Ile?Arg?Val?Lys?Asp?Leu?Ala?Lys?Ala?Gln?Ser?Glu

85 90 95

Asp?Ile?Leu?Gly?Gln?Leu?Gln?Arg?Ser?Asp?Val?Arg?Met?Ile?Asn?Gly

100 105 110

Val?Gly?Arg?Phe?Asp?Asp?Tyr?Asn?Thr?Lys?Gln?Thr?Thr?His?Tyr?Ile

115 120 125

Lys?Val?Thr?His?Ser?Asp?Gly?Ser?Glu?Glu?Thr?Val?Glu?Cys?Asp?Leu

130 135 140

Val?Leu?Val?Ala?Thr?Gly?Ala?Thr?Pro?Arg?Ile?Leu?Lys?Gly?Ala?Glu

145 150 155 160

Pro?Asp?Gly?Glu?Arg?Ile?Leu?Thr?Trp?Arg?Gln?Val?Tyr?Asp?Ile?Glu

165 170 175

Glu?Leu?Pro?Thr?His?Leu?Ile?Val?Val?Gly?Ser?Gly?Val?Thr?Gly?Ala

180 185 190

Glu?Phe?Val?Ser?Ala?Phe?Ala?Glu?Leu?Gly?Val?Lys?Val?Thr?Met?Val

195 200 205

Ala?Ser?Arg?Asp?Arg?Ile?Leu?Pro?His?Asp?Asp?Ala?Asp?Ala?Ala?Asp

210 215 220

Val?Leu?Glu?Thr?Val?Leu?Ala?Glu?Arg?Gly?Val?Ser?Leu?Glu?Lys?His

225 230 235 240

Ala?Arg?Val?Glu?Ser?Val?Thr?Arg?Thr?Glu?Asp?Gly?Gly?Val?Cys?Val

245 250 255

Arg?Thr?Ala?Asp?Gly?Arg?Glu?Ile?Tyr?Gly?Ser?His?Ala?Leu?Met?Thr

260 265 270

Val?Gly?Ser?Ile?Pro?Asn?Thr?Ala?Asp?Leu?Gly?Leu?Glu?Asn?Ile?Gly

275 280 285

Val?Glu?Leu?Ala?Pro?Ser?Gly?His?Ile?Lys?Val?Asp?Arg?Ser?Pro?Ala

290 295 300

Pro?Thr?Ser?Pro?Val?Cys?Thr?Gln?Gln?Val?Thr?Val?Leu?Thr?Tyr?Ser

305 310 315 320

His?Trp?Arg?Pro?Leu?Gln?Arg?Cys?Arg?Ala?Val?Ser?Pro?Cys?Ile?Thr

325 330 335

His?Ser?Val?Lys?Ala

340

<210>107

<211>1518

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(89)..(1495)

<223>FRXA02853

<400>107

aattcagcag?taatcattta?gacttggaac?cgcttaccag?tggtttcaac?aatgcattca?60

cccagctcac?acgtgtggag?gtgcctta?atg?gca?aag?agg?atc?gta?att?atc?ggc?115

Met?Ala?Lys?Arg?Ile?Val?Ile?Ile?Gly

1 5

ggt?gga?cct?gca?ggc?tat?gaa?gcc?gca?ctc?gca?ggc?gct?aaa?tac?ggt 163

Gly?Gly?Pro?Ala?Gly?Tyr?Glu?Ala?Ala?Leu?Ala?Gly?Ala?Lys?Tyr?Gly

10 15 20 25

gca?gaa?gtt?acc?gtt?att?gaa?gat?gtc?gga?gtt?ggc?gga?tcc?gca?gtc 211

Ala?Glu?Val?Thr?Val?Ile?Glu?Asp?Val?Gly?Val?Gly?Gly?Ser?Ala?Val

30 35 40

acc?atg?gac?tgt?gta?cct?tca?aag?tcc?ttc?atc?gct?ggt?acc?ggt?atc 259

Thr?Met?Asp?Cys?Val?Pro?Ser?Lys?Ser?Phe?Ile?Ala?Gly?Thr?Gly?Ile

45 50 55

aaa?acc?gac?ctc?cga?cgt?gct?gat?gac?atg?gga?ctt?aac?cgt?ggg?ctt 307

Lys?Thr?Asp?Leu?Arg?Arg?Ala?Asp?Asp?Met?Gly?Leu?Asn?Arg?Gly?Leu

60 65 70

gga?aaa?gca?cac?cta?gaa?atc?gat?gca?ctg?aac?atc?cgt?gtg?aag?gac 355

Gly?Lys?Ala?His?Leu?Glu?Ile?Asp?Ala?Leu?Asn?Ile?Arg?Val?Lys?Asp

75 80 85

ctt?gcg?aaa?gca?cag?tcc?gaa?gat?atc?ttg?ggc?cag?ctg?cag?cgc?tca 403

Leu?Ala?Lys?Ala?Gln?Ser?Glu?Asp?Ile?Leu?Gly?Gln?Leu?Gln?Arg?Ser

90 95 100 105

gat?gtc?cgc?atg?att?aac?ggt?gtg?ggc?cgc?ttt?gat?gat?tac?aac?acc 451

Asp?Val?Arg?Met?Ile?Asn?Gly?Val?Gly?Arg?Phe?Asp?Asp?Tyr?Asn?Thr

110 115 120

aag?caa?acc?acc?cac?tac?att?aaa?gtc?acc?cac?agc?gat?ggc?tcc?gaa 499

Lys?Gln?Thr?Thr?His?Tyr?Ile?Lys?Val?Thr?His?Ser?Asp?Gly?Ser?Glu

125 130 135

gaa?acc?gtt?gag?tgc?gat?ctg?gtg?ctg?gtt?gca?act?ggt?gca?acc?ccc 547

Glu?Thr?Val?Glu?Cys?Asp?Leu?Val?Leu?Val?Ala?Thr?Gly?Ala?Thr?Pro

140 145 150

cgc?att?ctt?aaa?ggt?gca?gag?cca?gac?ggc?gag?cgc?atc?ttg?acc?tgg 595

Arg?Ile?Leu?Lys?Gly?Ala?Glu?Pro?Asp?Gly?Glu?Arg?Ile?Leu?Thr?Trp

155 160 165

cgt?cag?gtc?tac?gac?att?gaa?gaa?ctc?ccc?acc?cac?ctt?atc?gtg?gtt 643

Arg?Gln?Val?Tyr?Asp?Ile?Glu?Glu?Leu?Pro?Thr?His?Leu?Ile?Val?Val

170 175 180 185

ggt?tcc?ggt?gtg?acc?ggt?gcg?gaa?ttt?gtc?tct?gcg?ttt?gct?gaa?ctc 691

Gly?Ser?Gly?Val?Thr?Gly?Ala?Glu?Phe?Val?Ser?Ala?Phe?Ala?Glu?Leu

190 195 200

ggc?gtc?aaa?gtc?acc?atg?gtg?gca?tcc?cgt?gac?cgc?att?ttg?cct?cac 739

Gly?Val?Lys?Val?Thr?Met?Val?Ala?Ser?Arg?Asp?Arg?Ile?Leu?Pro?His

205 210 215

gat?gac?gca?gat?gcc?gca?gac?gtg?ctg?gaa?acc?gtt?ctg?gct?gag?cgc 787

Asp?Asp?Ala?Asp?Ala?Ala?Asp?Val?Leu?Glu?Thr?Val?Leu?Ala?Glu?Arg

220 225 230

gga?gta?tcc?ctg?gaa?aag?cat?gcc?cgc?gtg?gag?tct?gtc?acc?cgc?acc 835

Gly?Val?Ser?Leu?Glu?Lys?His?Ala?Arg?Val?Glu?Ser?Val?Thr?Arg?Thr

235 240 245

gaa?gac?ggt?ggc?gtg?tgt?gtt?cgc?act?gct?gac?gga?cga?gaa?atc?tac 883

Glu?Asp?Gly?Gly?Val?Cys?Val?Arg?Thr?Ala?Asp?Gly?Arg?Glu?Ile?Tyr

250 255 260 265

ggt?tct?cac?gcg?ttg?atg?act?gtt?ggt?tcc?att?cca?aac?acg?gca?gat 931

Gly?Ser?His?Ala?Leu?Met?Thr?Val?Gly?Ser?Ile?Pro?Asn?Thr?Ala?Asp

270 275 280

ctt?ggc?ctg?gag?aac?atc?ggt?gtt?gag?ctg?gca?cca?tcc?ggc?cat?atc 979

Leu?Gly?Leu?Glu?Asn?Ile?Gly?Val?Glu?Leu?Ala?Pro?Ser?Gly?His?Ile

285 290 295

aag?gtt?gac?cgn?gtc?tcc?cgc?acc?aac?atc?ccc?ggt?gtg?tac?gca?gca 1027

Lys?Val?Asp?Arg?Val?Ser?Arg?Thr?Asn?Ile?Pro?Gly?Val?Tyr?Ala?Ala

300 305 310

ggt?gac?tgt?act?gac?cta?ttc?cca?ctg?gcg?tcc?gtt?gca?gcg?atg?cag 1075

Gly?Asp?Cys?Thr?Asp?Leu?Phe?Pro?Leu?Ala?Ser?Val?Ala?Ala?Met?Gln

315 320 325

ggc?cgt?atc?gcc?atg?tat?cac?gca?ctc?ggt?gaa?ggc?gtg?agc?ccc?atc 1123

Gly?Arg?Ile?Ala?Met?Tyr?His?Ala?Leu?Gly?Glu?Gly?Val?Ser?Pro?Ile

330 335 340 345

cgt?ttg?aag?act?gtt?gcc?acc?gca?gtg?ttt?acc?cgc?cca?gag?atc?gca 1171

Arg?Leu?Lys?Thr?Val?Ala?Thr?Ala?Val?Phe?Thr?Arg?Pro?Glu?Ile?Ala

350 355 360

gca?gta?ggt?atc?acc?cat?gca?caa?gtt?gat?tcc?ggc?gaa?gtg?tct?gct 1219

Ala?Val?Gly?Ile?Thr?His?Ala?Gln?Val?Asp?Ser?Gly?Glu?Val?Ser?Ala

365 370 375

cgc?gtg?att?gtg?ctt?cct?ttg?gct?act?aac?cca?cgc?gcc?aag?atg?cgt 1267

Arg?Val?Ile?Val?Leu?Pro?Leu?Ala?Thr?Asn?Pro?Arg?Ala?Lys?Met?Arg

380 385 390

tcc?ctg?cgc?cac?ggt?ttt?gtg?aag?ctg?ttc?tgc?cgc?cgt?aac?tct?ggc 1315

Ser?Leu?Arg?His?Gly?Phe?Val?Lys?Leu?Phe?Cys?Arg?Arg?Asn?Ser?Gly

395 400 405

ctg?atc?atc?ggt?ggt?gtc?gtg?gtg?gca?ccg?acc?gcg?tct?gag?ctg?atc 1363

Leu?lle?Ile?Gly?Gly?Val?Val?Val?Ala?Pro?Thr?Ala?Ser?Glu?Leu?Ile

410 415 420 425

cta?ccg?atc?gct?gtg?gca?gtg?acc?aac?cgt?ctg?aca?gtt?gct?gat?ctg 1411

Leu?Pro?Ile?Ala?Val?Ala?Val?Thr?Asn?Arg?Leu?Thr?Val?Ala?Asp?Leu

430 435 440

gct?gat?acc?ttc?gcg?gtg?tac?cca?tca?ttg?tca?ggt?tcg?att?act?gaa 1459

Ala?Asp?Thr?Phe?Ala?Val?Tyr?Pro?Ser?Leu?Ser?Gly?Ser?Ile?Thr?Glu

445 450 455

gca?gca?cgt?cag?ctg?gtt?caa?cat?gat?gat?cta?ggc?taatttttct 1505

Ala?Ala?Arg?Gln?Leu?Val?Gln?His?Asp?Asp?Leu?Gly

460 465

gagtcttaga?ttt 1518

<210>108

<211>469

<212>PRT

＜213〉Corynebacterium glutamicum

<400>108

Met?Ala?Lys?Arg?Ile?Val?Ile?Ile?Gly?Gly?Gly?Pro?Ala?Gly?Tyr?Glu

1 5 10 15

Ala?Ala?Leu?Ala?Gly?Ala?Lys?Tyr?Gly?Ala?Glu?Val?Thr?Val?Ile?Glu

20 25 30

Asp?Val?Gly?Val?Gly?Gly?Ser?Ala?Val?Thr?Met?Asp?Cys?Val?Pro?Ser

35 40 45

Lys?Ser?Phe?Ile?Ala?Gly?Thr?Gly?Ile?Lys?Thr?Asp?Leu?Arg?Arg?Ala

50 55 60

Asp?Asp?Met?Gly?Leu?Asn?Arg?Gly?Leu?Gly?Lys?Ala?His?Leu?Glu?Ile

65 70 75 80

Asp?Ala?Leu?Asn?Ile?Arg?Val?Lys?Asp?Leu?Ala?Lys?Ala?Gln?Ser?Glu

85 90 95

Asp?Ile?Leu?Gly?Gln?Leu?Gln?Arg?Ser?Asp?Val?Arg?Met?Ile?Asn?Gly

100 105 110

Val?Gly?Arg?Phe?Asp?Asp?Tyr?Asn?Thr?Lys?Gln?Thr?Thr?His?Tyr?Ile

115 120 125

Lys?Val?Thr?His?Ser?Asp?Gly?Ser?Glu?Glu?Thr?Val?Glu?Cys?Asp?Leu

130 135 140

Val?Leu?Val?Ala?Thr?Gly?Ala?Thr?Pro?Arg?Ile?Leu?Lys?Gly?Ala?Glu

145 150 155 160

Pro?Asp?Gly?Glu?Arg?Ile?Leu?Thr?Trp?Arg?Gln?Val?Tyr?Asp?Ile?Glu

165 170 175

Glu?Leu?Pro?Thr?His?Leu?Ile?Val?Val?Gly?Ser?Gly?Val?Thr?Gly?Ala

180 185 190

Glu?Phe?Val?Ser?Ala?Phe?Ala?Glu?Leu?Gly?Val?Lys?Val?Thr?Met?Val

195 200 205

Ala?Ser?Arg?Asp?Arg?Ile?Leu?Pro?His?Asp?Asp?Ala?Asp?Ala?Ala?Asp

210 215 220

Val?Leu?Glu?Thr?Val?Leu?Ala?Glu?Arg?Gly?Val?Ser?Leu?Glu?Lys?His

225 230 235 240

Ala?Arg?Val?Glu?Ser?Val?Thr?Arg?Thr?Glu?Asp?Gly?Gly?Val?Cys?Val

245 250 255

Arg?Thr?Ala?Asp?Gly?Arg?Glu?Ile?Tyr?Gly?Ser?His?Ala?Leu?Met?Thr

260 265 270

Val?Gly?Ser?Ile?Pro?Asn?Thr?Ala?Asp?Leu?Gly?Leu?Glu?Asn?Ile?Gly

275 280 285

Val?Glu?Leu?Ala?Pro?Ser?Gly?His?Ile?Lys?Val?Asp?Arg?Val?Ser?Arg

290 295 300

Thr?Asn?Ile?Pro?Gly?Val?Tyr?Ala?Ala?Gly?Asp?Cys?Thr?Asp?Leu?Phe

305 310 315 320

Pro?Leu?Ala?Ser?Val?Ala?Ala?Met?Gln?Gly?Arg?Ile?Ala?Met?Tyr?His

325 330 335

Ala?Leu?Gly?Glu?Gly?Val?Ser?Pro?Ile?Arg?Leu?Lys?Thr?Val?Ala?Thr

340 345 350

Ala?Val?Phe?Thr?Arg?Pro?Glu?Ile?Ala?Ala?Val?Gly?Ile?Thr?His?Ala

355 360 365

Gln?Val?Asp?Ser?Gly?Glu?Val?Ser?Ala?Arg?Val?Ile?Val?Leu?Pro?Leu

370 375 380

Ala?Thr?Asn?Pro?Arg?Ala?Lys?Met?Arg?Ser?Leu?Arg?His?Gly?Phe?Val

385 390 395 400

Lys?Leu?Phe?Cys?Arg?Arg?Asn?Ser?Gly?Leu?Ile?Ile?Gly?Gly?Val?Val

405 410 415

Val?Ala?Pro?Thr?Ala?Ser?Glu?Leu?Ile?Leu?Pro?Ile?Ala?Val?Ala?Val

420 425 430

Thr?Asn?Arg?Leu?Thr?Val?Ala?Asp?Leu?Ala?Asp?Thr?Phe?Ala?Val?Tyr

435 440 445

Pro?Ser?Leu?Ser?Gly?Ser?Ile?Thr?Glu?Ala?Ala?Arg?Gln?Leu?Val?Gln

450 455 460

His?Asp?Asp?Leu?Gly

465

<210>109

<211>2895

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(2872)

<223>RXA02259

<400>109

atgagcccat?gaaagccatc?gaaatcaatc?gcccagctaa?acacctgttt?tgctgggtga?60

ttttttatct?catgcacgcc?aacaccctca?atgtgaaaga?gtg?ttt?aaa?gta?gtt 115

Val?Phe?Lys?Val?Val

1 5

atg?act?gat?ttt?tta?cgc?gat?gac?atc?agg?ttc?ctc?ggt?caa?atc?ctc 163

Met?Thr?Asp?Phe?Leu?Arg?Asp?Asp?Ile?Arg?Phe?Leu?Gly?Gln?Ile?Leu

10 15 20

ggt?gag?gta?att?gcg?gaa?caa?gaa?ggc?cag?gag?gtt?tat?gaa?ctg?gtc 211

Gly?Glu?Val?Ile?Ala?Glu?Gln?Glu?Gly?Gln?Glu?Val?Tyr?Glu?Leu?Val

25 30 35

gaa?caa?gcg?cgc?ctg?act?tct?ttt?gat?atc?gcc?aag?ggc?aac?gcc?gaa 259

Glu?Gln?Ala?Arg?Leu?Thr?Ser?Phe?Asp?Ile?Ala?Lys?Gly?Asn?Ala?Glu

40 45 50

atg?gat?agc?ctg?gtt?cag?gtt?ttc?gac?ggc?att?act?cca?gcc?aag?gca 307

Met?Asp?Ser?Leu?Val?Gln?Val?Phe?Asp?Gly?Ile?Thr?Pro?Ala?Lys?Ala

55 60 65

aca?ccg?att?gct?cgc?gca?ttt?tcc?cac?ttc?gct?ctg?ctg?gct?aac?ctg 355

Thr?Pro?Ile?Ala?Arg?Ala?Phe?Ser?His?Phe?Ala?Leu?Leu?Ala?Asn?Leu

70 75 80 85

gcg?gaa?gac?ctc?tac?gat?gaa?gag?ctt?cgt?gaa?cag?gct?ctc?gat?gca 403

Ala?Glu?Asp?Leu?Tyr?Asp?Glu?Glu?Leu?Arg?Glu?Gln?Ala?Leu?Asp?Ala

90 95 100

ggc?gac?acc?cct?ccg?gac?agc?act?ctt?gat?gcc?acc?tgg?ctg?aaa?ctc 451

Gly?Asp?Thr?Pro?Pro?Asp?Ser?Thr?Leu?Asp?Ala?Thr?Trp?Leu?Lys?Leu

105 110 115

aat?gag?ggc?aat?gtt?ggc?gca?gaa?gct?gtg?gcc?gat?gtg?ctg?cgc?aat 499

Asn?Glu?Gly?Asn?Val?Gly?Ala?Glu?Ala?Val?Ala?Asp?Val?Leu?Arg?Asn

120 125 130

gct?gag?gtg?gcg?ccg?gtt?ctg?act?gcg?cac?cca?act?gag?act?cgc?cgc 547

Ala?Glu?Val?Ala?Pro?Val?Leu?Thr?Ala?His?Pro?Thr?Glu?Thr?Arg?Arg

135 140 145

cgc?act?gtt?ttt?gat?gcg?caa?aag?tgg?atc?acc?acc?cac?atg?cgt?gaa 595

Arg?Thr?Val?Phe?Asp?Ala?Gln?Lys?Trp?Ile?Thr?Thr?His?Met?Arg?Glu

150 155 160 165

cgc?cac?gct?ttg?cag?tct?gcg?gag?cct?acc?gct?cgt?acg?caa?agc?aag 643

Arg?His?Ala?Leu?Gln?Ser?Ala?Glu?Pro?Thr?Ala?Arg?Thr?Gln?Ser?Lys

170 175 180

ttg?gat?gag?atc?gag?aag?aac?atc?cgc?cgt?cgc?atc?acc?att?ttg?tgg 691

Leu?Asp?Glu?Ile?Glu?Lys?Asn?Ile?Arg?Arg?Arg?Ile?Thr?Ile?Leu?Trp

185 190 195

cag?acc?gcg?ttg?att?cgt?gtg?gcc?cgc?cca?cgt?atc?gag?gac?gag?atc 739

Gln?Thr?Ala?Leu?Ile?Arg?Val?Ala?Arg?Pro?Arg?Ile?Glu?Asp?Glu?Ile

200 205 210

gaa?gta?ggg?ctg?cgc?tac?tac?aag?ctg?agc?ctt?ttg?gaa?gag?att?cca 787

Glu?Val?Gly?Leu?Arg?Tyr?Tyr?Lys?Leu?Ser?Leu?Leu?Glu?Glu?Ile?Pro

215 220 225

cgt?atc?aac?cgt?gat?gtg?gct?gtt?gag?ctt?cgt?gag?cgt?ttc?ggc?gag 835

Arg?Ile?Asn?Arg?Asp?Val?Ala?Val?Glu?Leu?Arg?Glu?Arg?Phe?Gly?Glu

230 235 240 245

ggt?gtt?cct?ttg?aag?ccc?gtg?gtc?aag?cca?ggt?tcc?tgg?att?ggt?gga 883

Gly?Val?Pro?Leu?Lys?Pro?Val?Val?Lys?Pro?Gly?Ser?Trp?Ile?Gly?Gly

250 255 260

gac?cac?gac?ggt?aac?cct?tat?gtc?acc?gcg?gaa?aca?gtt?gag?tat?tcc 931

Asp?His?Asp?Gly?Asn?Pro?Tyr?Val?Thr?Ala?Glu?Thr?Val?Glu?Tyr?Ser

265 270 275

act?cac?cgc?gct?gcg?gaa?acc?gtg?ctc?aag?tac?tat?gca?cgc?cag?ctg 979

Thr?His?Arg?Ala?Ala?Glu?Thr?Val?Leu?Lys?Tyr?Tyr?Ala?Arg?Gln?Leu

280 285 290

cat?tcc?ctc?gag?cat?gag?ctc?agc?ctg?tcg?gac?cgc?atg?aat?aag?gtc 1027

His?Ser?Leu?Glu?His?Glu?Leu?Ser?Leu?Ser?Asp?Arg?Met?Asn?Lys?Val

295 300 305

acc?ccg?cag?ctg?ctt?gcg?ctg?gca?gat?gca?ggg?cac?aac?gac?gtg?cca 1075

Thr?Pro?Gln?Leu?Leu?Ala?Leu?Ala?Asp?Ala?Gly?His?Ash?Asp?Val?Pro

310 315 320 325

agc?cgc?gtg?gat?gag?cct?tat?cga?cgc?gcc?gtc?cat?ggc?gtt?cgc?gga 1123

Ser?Arg?Val?Asp?Glu?Pro?Tyr?Arg?Arg?Ala?Val?His?Gly?Val?Arg?Gly

330 335 340

cgt?atc?ctc?gcg?acg?acg?gcc?gag?ctg?atc?ggc?gag?gac?gcc?gtt?gag 1171

Arg?Ile?Leu?Ala?Thr?Thr?Ala?Glu?Leu?Ile?Gly?Glu?Asp?Ala?Val?Glu

345 350 355

ggc?gtg?tgg?ttc?aag?gtc?ttt?act?cca?tac?gca?tct?ccg?gaa?gaa?ttc 1219

Gly?Val?Trp?Phe?Lys?Val?Phe?Thr?Pro?Tyr?Ala?Ser?Pro?Glu?Glu?Phe

360 365 370

tta?aac?gat?gcg?ttg?acc?att?gat?cat?tct?ctg?cgt?gaa?tcc?aag?gac 1267

Leu?Asn?Asp?Ala?Leu?Thr?Ile?Asp?His?Ser?Leu?Arg?Glu?Ser?Lys?Asp

375 380 385

gtt?ctc?att?gcc?gat?gat?cgt?ttg?tct?gtg?ctg?att?tct?gcc?atc?gag 1315

Val?Leu?Ile?Ala?Asp?Asp?Arg?Leu?Ser?Val?Leu?Ile?Ser?Ala?Ile?Glu

390 395 400 405

agc?ttt?gga?ttc?aac?ctt?tac?gca?ctg?gat?ctg?cgc?caa?aac?tcc?gaa 1363

Ser?Phe?Gly?Phe?Asn?Leu?Tyr?Ala?Leu?Asp?Leu?Arg?Gln?Asn?Ser?Glu

410 415 420

agc?tac?gag?gac?gtc?ctc?acc?gag?ctt?ttc?gaa?cgc?gcc?caa?gtc?acc 1411

Ser?Tyr?Glu?Asp?Val?Leu?Thr?Glu?Leu?Phe?Glu?Arg?Ala?Gln?Val?Thr

425 430 435

gca?aac?tac?cgc?gag?ctg?tct?gaa?gca?gag?aag?ctt?gag?gtg?ctg?ctg 1459

Ala?Asn?Tyr?Arg?Glu?Leu?Ser?Glu?Ala?Glu?Lys?Leu?Glu?Val?Leu?Leu

440 445 450

aag?gaa?ctg?cgc?agc?cct?cgt?ccg?ctg?atc?ccg?cac?ggt?tca?gat?gaa 1507

Lys?Glu?Leu?Arg?Ser?Pro?Arg?Pro?Leu?Ile?Pro?His?Gly?Ser?Asp?Glu

455 460 465

tac?agc?gag?gtc?acc?gac?cgc?gag?ctc?ggc?atc?ttc?cgc?acc?gcg?tcg 1555

Tyr?Ser?Glu?Val?Thr?Asp?Arg?Glu?Leu?Gly?Ile?Phe?Arg?Thr?Ala?Ser

470 475 480 485

gag?gct?gtt?aag?aaa?ttc?ggg?cca?cgg?atg?gtg?cct?cac?tgc?atc?atc 1603

Glu?Ala?Val?Lys?Lys?Phe?Gly?Pro?Arg?Met?Val?Pro?His?Cys?Ile?Ile

490 495 500

tcc?atg?gca?tca?tcg?gtc?acc?gat?gtg?ctc?gag?ccg?atg?gtg?ttg?ctc 1651

Ser?Met?Ala?Ser?Ser?Val?Thr?Asp?Val?Leu?Glu?Pro?Met?Val?Leu?Leu

505 510 515

aag?gaa?ttc?gga?ctc?atc?gca?gcc?aac?ggc?gac?aac?cca?cgc?ggc?acc 1699

Lys?Glu?Phe?Gly?Leu?Ile?Ala?Ala?Asn?Gly?Asp?Asn?Pro?Arg?Gly?Thr

520 525 530

gtc?gat?gtc?atc?cca?ctg?ttc?gaa?acc?atc?gaa?gat?ctc?cag?gcc?ggc 1747

Val?Asp?Val?Ile?Pro?Leu?Phe?Glu?Thr?Ile?Glu?Asp?Leu?Gln?Ala?Gly

535 540 545

gcc?gga?atc?ctc?gac?gaa?ctg?tgg?aaa?att?gat?ctc?tac?cgc?aac?tac 1795

Ala?Gly?Ile?Leu?Asp?Glu?Leu?Trp?Lys?Ile?Asp?Leu?Tyr?Arg?Asn?Tyr

550 555 560 565

ctc?ctg?cag?cgc?gac?aac?gtc?cag?gaa?gtc?atg?ctc?ggt?tac?tcc?gat 1843

Leu?Leu?Gln?Arg?Asp?Asn?Val?Gln?Glu?Val?Met?Leu?Gly?Tyr?Ser?Asp

570 575 580

tcc?aac?aag?gat?ggc?gga?tat?ttc?tcc?gca?aac?tgg?gcg?ctt?tac?gac 1891

Ser?Asn?Lys?Asp?Gly?Gly?Tyr?Phe?Ser?Ala?Asn?Trp?Ala?Leu?Tyr?Asp

585 590 595

gcg?gaa?ctg?cag?ctc?gtc?gaa?cta?tgc?cga?tca?gcc?ggg?gtc?aag?ctt 1939

Ala?Glu?Leu?Gln?Leu?Val?Glu?Leu?Cys?Arg?Ser?Ala?Gly?Val?Lys?Leu

600 605 610

cgc?ctg?ttc?cac?ggc?cgt?ggt?ggc?acc?gtc?ggc?cgc?ggt?ggc?gga?cct 1987

Arg?Leu?Phe?His?Gly?Arg?Gly?Gly?Thr?Val?Gly?Arg?Gly?Gly?Gly?Pro

615 620 625

tcc?tac?gac?gcg?att?ctt?gcc?cag?ccc?agg?ggg?gct?gtc?caa?ggt?tcc 2035

Ser?Tyr?Asp?Ala?Ile?Leu?Ala?Gln?Pro?Arg?Gly?Ala?Val?Gln?Gly?Ser

630 635 640 645

gtg?cgc?atc?acc?gag?cag?ggc?gag?atc?atc?tcc?gct?aag?tac?ggc?aac 2083

Val?Arg?Ile?Thr?Glu?Gln?Gly?Glu?Ile?Ile?Ser?Ala?Lys?Tyr?Gly?Asn

650 655 660

ccc?gaa?acc?gcg?cgc?cga?aac?ctc?gaa?gcc?ctg?gtc?tca?gcc?acg?ctt 2131

Pro?Glu?Thr?Ala?Arg?Arg?Asn?Leu?Glu?Ala?Leu?Val?Ser?Ala?Thr?Leu

665 670 675

gag?gca?tcg?ctt?ctc?gac?gtc?tcc?gaa?ctc?acc?gat?cac?caa?cgc?gcg 2179

Glu?Ala?Ser?Leu?Leu?Asp?Val?Ser?Glu?Leu?Thr?Asp?His?Gln?Arg?Ala

680 685 690

tac?gac?atc?atg?agt?gag?atc?tct?gag?ctc?agc?ttg?aag?aag?tac?gcc 2227

Tyr?Asp?Ile?Met?Ser?Glu?Ile?Ser?Glu?Leu?Ser?Leu?Lys?Lys?Tyr?Ala

695 700 705

tcc?ttg?gtg?cac?gag?gat?caa?ggc?ttc?atc?gat?tac?ttc?acc?cag?tcc 2275

Ser?Leu?Val?His?Glu?Asp?Gln?Gly?Phe?Ile?Asp?Tyr?Phe?Thr?Gln?Ser

710 715 720 725

acg?ccg?ctg?cag?gag?att?gga?tcc?ctc?aac?atc?gga?tcc?agg?cct?tcc 2323

Thr?Pro?Leu?Gln?Glu?Ile?Gly?Ser?Leu?Asn?Ile?Gly?Ser?Arg?Pro?Ser

730 735 740

tca?cgc?aag?cag?acc?tcc?tcg?gtg?gaa?gat?ttg?cga?gcc?atc?cca?tgg 2371

Ser?Arg?Lys?Gln?Thr?Ser?Ser?Val?Glu?Asp?Leu?Arg?Ala?Ile?Pro?Trp

745 750 755

gtg?ctc?agc?tgg?tca?cag?tct?cgt?gtc?atg?ctg?cca?ggc?tgg?ttt?ggt 2419

Val?Leu?Ser?Trp?Ser?Gln?Ser?Arg?Val?Met?Leu?Pro?Gly?Trp?Phe?Gly

760 765 770

gtc?gga?acc?gca?tta?gag?cag?tgg?att?ggc?gaa?ggg?gag?cag?gcc?acc 2467

Val?Gly?Thr?Ala?Leu?Glu?Gln?Trp?Ile?Gly?Glu?Gly?Glu?Gln?Ala?Thr

775 780 785

caa?cgc?att?gcc?gag?ctg?caa?aca?ctc?aat?gag?tcc?tgg?cca?ttt?ttc 2515

Gln?Arg?Ile?Ala?Glu?Leu?Gln?Thr?Leu?Asn?Glu?Ser?Trp?Pro?Phe?Phe

790 795 800 805

acc?tca?gtg?ttg?gat?aac?atg?gct?cag?gtg?atg?tcc?aag?gca?gag?ctg 2563

Thr?Ser?Val?Leu?Asp?Asn?Met?Ala?Gln?Val?Met?Ser?Lys?Ala?Glu?Leu

810 815 820

cgt?ttg?gca?aag?ctc?tac?gca?gac?ctg?atc?cca?gat?acg?gaa?gta?gcc 2611

Arg?Leu?Ala?Lys?Leu?Tyr?Ala?Asp?Leu?Ile?Pro?Asp?Thr?Glu?Val?Ala

825 830 835

gag?cga?gtc?tat?tcc?gtc?atc?cgc?gag?gag?tac?ttc?ctg?acc?aag?aag 2659

Glu?Arg?Val?Tyr?Ser?Val?Ile?Arg?Glu?Glu?Tyr?Phe?Leu?Thr?Lys?Lys

840 845 850

atg?ttc?tgc?gta?atc?acc?ggc?tct?gat?gat?ctg?ctt?gat?gac?aac?cca 2707

Met?Phe?Cys?Val?Ile?Thr?Gly?Ser?Asp?Asp?Leu?Leu?Asp?Asp?Asn?Pro

855 860 865

ctt?ctc?gca?cgc?tct?gtc?cag?cgc?cga?tac?ccc?tac?ctg?ctt?cca?ctc 2755

Leu?Leu?Ala?Arg?Ser?Val?Gln?Arg?Arg?Tyr?Pro?Tyr?Leu?Leu?Pro?Leu

870 875 880 885

aac?gtg?atc?cag?gta?gag?atg?atg?cga?cgc?tac?cga?aaa?ggc?gac?caa 2803

Asn?Val?Ile?Gln?Val?Glu?Met?Met?Arg?Arg?Tyr?Arg?Lys?Gly?Asp?Gln

890 895 900

agc?gag?caa?gtg?tcc?cgc?aac?att?cag?ctg?acc?atg?aac?ggt?ctt?tcc 2851

Ser?Glu?Gln?Val?Ser?Arg?Asn?Ile?Gln?Leu?Thr?Met?Asn?Gly?Leu?Ser

905 910 915

act?gcg?ctg?cgc?aac?tcc?ggc?tagtccagcc?ggctgggtag?tac 2895

Thr?Ala?Leu?Arg?Asn?Ser?Gly

920

<210>110

<211>924

<212>PRT

＜213〉Corynebacterium glutamicum

<400>110

Val?Phe?Lys?Val?Val?Met?Thr?Asp?Phe?Leu?Arg?Asp?Asp?Ile?Arg?Phe

1 5 10 15

Leu?Gly?Gln?Ile?Leu?Gly?Glu?Val?Ile?Ala?Glu?Gln?Glu?Gly?Gln?Glu

20 25 30

Val?Tyr?Glu?Leu?Val?Glu?Gln?Ala?Arg?Leu?Thr?Ser?Phe?Asp?Ile?Ala

35 40 45

Lys?Gly?Asn?Ala?Glu?Met?Asp?Ser?Leu?Val?Gln?Val?Phe?Asp?Gly?Ile

50 55 60

Thr?Pro?Ala?Lys?Ala?Thr?Pro?Ile?Ala?Arg?Ala?Phe?Ser?His?Phe?Ala

65 70 75 80

Leu?Leu?Ala?Asn?Leu?Ala?Glu?Asp?Leu?Tyr?Asp?Glu?Glu?Leu?Arg?Glu

85 90 95

Gln?Ala?Leu?Asp?Ala?Gly?Asp?Thr?Pro?Pro?Asp?Ser?Thr?Leu?Asp?Ala

100 105 110

Thr?Trp?Leu?Lys?Leu?Asn?Glu?Gly?Asn?Val?Gly?Ala?Glu?Ala?Val?Ala

115 120 125

Asp?Val?Leu?Arg?Asn?Ala?Glu?Val?Ala?Pro?Val?Leu?Thr?Ala?His?Pro

130 135 140

Thr?Glu?Thr?Arg?Arg?Arg?Thr?Val?Phe?Asp?Ala?Gln?Lys?Trp?Ile?Thr

145 150 155 160

Thr?His?Met?Arg?Glu?Arg?His?Ala?Leu?Gln?Ser?Ala?Glu?Pro?Thr?Ala

165 170 175

Arg?Thr?Gln?Ser?Lys?Leu?Asp?Glu?Ile?Glu?Lys?Asn?Ile?Arg?Arg?Arg

180 185 190

Ile?Thr?Ile?Leu?Trp?Gln?Thr?Ala?Leu?Ile?Arg?Val?Ala?Arg?Pro?Arg

195 200 205

Ile?Glu?Asp?Glu?Ile?Glu?Val?Gly?Leu?Arg?Tyr?Tyr?Lys?Leu?Ser?Leu

210 215 220

Leu?Glu?Glu?Ile?Pro?Arg?Ile?Asn?Arg?Asp?Val?Ala?Val?Glu?Leu?Arg

225 230 235 240

Glu?Arg?Phe?Gly?Glu?Gly?Val?Pro?Leu?Lys?Pro?Val?Val?Lys?Pro?Gly

245 250 255

Ser?Trp?Ile?Gly?Gly?Asp?His?Asp?Gly?Asn?Pro?Tyr?Val?Thr?Ala?Glu

260 265 270

Thr?Val?Glu?Tyr?Ser?Thr?His?Arg?Ala?Ala?Glu?Thr?Val?Leu?Lys?Tyr

275 280 285

Tyr?Ala?Arg?Gln?Leu?His?Ser?Leu?Glu?His?Glu?Leu?Ser?Leu?Ser?Asp

290 295 300

Arg?Met?Asn?Lys?Val?Thr?Pro?Gln?Leu?Leu?Ala?Leu?Ala?Asp?Ala?Gly

305 310 315 320

His?Asn?Asp?Val?Pro?Ser?Arg?Val?Asp?Glu?Pro?Tyr?Arg?Arg?Ala?Val

325 330 335

His?Gly?Val?Arg?Gly?Arg?Ile?Leu?Ala?Thr?Thr?Ala?Glu?Leu?Ile?Gly

340 345 350

Glu?Asp?Ala?Val?Glu?Gly?Val?Trp?Phe?Lys?Val?Phe?Thr?Pro?Tyr?Ala

355 360 365

Ser?Pro?Glu?Glu?Phe?Leu?Asn?Asp?Ala?Leu?Thr?Ile?Asp?His?Ser?Leu

370 375 380

Arg?Glu?Ser?Lys?Asp?Val?Leu?Ile?Ala?Asp?Asp?Arg?Leu?Ser?Val?Leu

385 390 395 400

Ile?Ser?Ala?Ile?Glu?Ser?Phe?Gly?Phe?Asn?Leu?Tyr?Ala?Leu?Asp?Leu

405 410 415

Arg?Gln?Asn?Ser?Glu?Ser?Tyr?Glu?Asp?Val?Leu?Thr?Glu?Leu?Phe?Glu

420 425 430

Arg?Ala?Gln?Val?Thr?Ala?Asn?Tyr?Arg?Glu?Leu?Ser?Glu?Ala?Glu?Lys

435 440 445

Leu?Glu?Val?Leu?Leu?Lys?Glu?Leu?Arg?Ser?Pro?Arg?Pro?Leu?Ile?Pro

450 455 460

His?Gly?Ser?Asp?Glu?Tyr?Ser?Glu?Val?Thr?Asp?Arg?Glu?Leu?Gly?Ile

465 470 475 480

Phe?Arg?Thr?Ala?Ser?Glu?Ala?Val?Lys?Lys?Phe?Gly?Pro?Arg?Met?Val

485 490 495

Pro?His?Cys?Ile?Ile?Ser?Met?Ala?Ser?Ser?Val?Thr?Asp?Val?Leu?Glu

500 505 510

Pro?Met?Val?Leu?Leu?Lys?Glu?Phe?Gly?Leu?Ile?Ala?Ala?Asn?Gly?Asp

515 520 525

Asn?Pro?Arg?Gly?Thr?Val?Asp?Val?Ile?Pro?Leu?Phe?Glu?Thr?Ile?Glu

530 535 540

Asp?Leu?Gln?Ala?Gly?Ala?Gly?Ile?Leu?Asp?Glu?Leu?Trp?Lys?Ile?Asp

545 550 555 560

Leu?Tyr?Arg?Asn?Tyr?Leu?Leu?Gln?Arg?Asp?Asn?Val?Gln?Glu?Val?Met

565 570 575

Leu?Gly?Tyr?Ser?Asp?Ser?Asn?Lys?Asp?Gly?Gly?Tyr?Phe?Ser?Ala?Asn

580 585 590

Trp?Ala?Leu?Tyr?Asp?Ala?Glu?Leu?Gln?Leu?Val?Glu?Leu?Cys?Arg?Ser

595 600 605

Ala?Gly?Val?Lys?Leu?Arg?Leu?Phe?His?Gly?Arg?Gly?Gly?Thr?Val?Gly

610 615 620

Arg?Gly?Gly?Gly?Pro?Ser?Tyr?Asp?Ala?Ile?Leu?Ala?Gln?Pro?Arg?Gly

625 630 635 640

Ala?Val?Gln?Gly?Ser?Val?Arg?Ile?Thr?Glu?Gln?Gly?Glu?Ile?Ile?Ser

645 650 655

Ala?Lys?Tyr?Gly?Asn?Pro?Glu?Thr?Ala?Arg?Arg?Asn?Leu?Glu?Ala?Leu

660 665 670

Val?Ser?Ala?Thr?Leu?Glu?Ala?Ser?Leu?Leu?Asp?Val?Ser?Glu?Leu?Thr

675 680 685

Asp?His?Gln?Arg?Ala?Tyr?Asp?Ile?Met?Ser?Glu?Ile?Ser?Glu?Leu?Ser

690 695 700

Leu?Lys?Lys?Tyr?Ala?Ser?Leu?Val?His?Glu?Asp?Gln?Gly?Phe?Ile?Asp

705 710 715 720

Tyr?Phe?Thr?Gln?Ser?Thr?Pro?Leu?Gln?Glu?Ile?Gly?Ser?Leu?Asn?Ile

725 730 735

Gly?Ser?Arg?Pro?Ser?Ser?Arg?Lys?Gln?Thr?Ser?Ser?Val?Glu?Asp?Leu

740 745 750

Arg?Ala?Ile?Pro?Trp?Val?Leu?Ser?Trp?Ser?Gln?Ser?Arg?Val?Met?Leu

755 760 765

Pro?Gly?Trp?Phe?Gly?Val?Gly?Thr?Ala?Leu?Glu?Gln?Trp?Ile?Gly?Glu

770 775 780

Gly?Glu?Gln?Ala?Thr?Gln?Arg?Ile?Ala?Glu?Leu?Gln?Thr?Leu?Asn?Glu

785 790 795 800

Ser?Trp?Pro?Phe?Phe?Thr?Ser?Val?Leu?Asp?Asn?Met?Ala?Gln?Val?Met

805 810 815

Ser?Lys?Ala?Glu?Leu?Arg?Leu?Ala?Lys?Leu?Tyr?Ala?Asp?Leu?Ile?Pro

820 825 830

Asp?Thr?Glu?Val?Ala?Glu?Arg?Val?Tyr?Ser?Val?Ile?Arg?Glu?Glu?Tyr

835 840 845

Phe?Leu?Thr?Lys?Lys?Met?Phe?Cys?Val?Ile?Thr?Gly?Ser?Asp?Asp?Leu

850 855 860

Leu?Asp?Asp?Asn?Pro?Leu?Leu?Ala?Arg?Ser?Val?Gln?Arg?Arg?Tyr?Pro

865 870 875 880

Tyr?Leu?Leu?Pro?Leu?Asn?Val?Ile?Gln?Val?Glu?Met?Met?Arg?Arg?Tyr

885 890 895

Arg?Lys?Gly?Asp?Gln?Ser?Glu?Gln?Val?Ser?Arg?Asn?Ile?Gln?Leu?Thr

900 905 910

Met?Asn?Gly?Leu?Ser?Thr?Ala?Leu?Arg?Asn?Ser?Gly

915 920

<210>111

<211>939

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(916)

<223>RXN02326

<400>111

ccaggcggac?agttgtccaa?cctgcgtgca?caggccaccg?cactgggcct?tgcggatcgt?60

ttcgaactca?tcgaagacaa?ctacgcaagc?cgttaatgag?atg?ctg?gga?cgc?cca 115

Met?Leu?Gly?Arg?Pro

1 5

acc?aag?gtc?acc?cca?tcc?tcc?aag?gtt?gtt?ggc?gac?ctc?gca?ctc?cac 163

Thr?Lys?Val?Thr?Pro?Ser?Ser?Lys?Val?Val?Gly?Asp?Leu?Ala?Leu?His

10 15 20

ctc?gtt?ggt?gcg?ggt?gtg?gat?cca?gca?gac?ttt?gct?gcc?gat?cca?caa 211

Leu?Val?Gly?Ala?Gly?Val?Asp?Pro?Ala?Asp?Phe?Ala?Ala?Asp?Pro?Gln

25 30 35

aag?tac?gac?atc?cca?gac?tct?gtc?atc?gcg?ttc?ctg?cgc?ggc?gag?ctt 259

Lys?Tyr?Asp?Ile?Pro?Asp?Ser?Val?Ile?Ala?Phe?Leu?Arg?Gly?Glu?Leu

40 45 50

ggt?aac?cct?cca?ggt?ggc?tgg?cca?gag?cca?ctg?cgc?acc?cgc?gca?ctg 307

Gly?Asn?Pro?Pro?Gly?Gly?Trp?Pro?Glu?Pro?Leu?Arg?Thr?Arg?Ala?Leu

55 60 65

gaa?ggc?cgc?tcc?gaa?ggc?aag?gca?cct?ctg?acg?gaa?gtt?cct?gag?gaa 355

Glu?Gly?Arg?Ser?Glu?Gly?Lys?Ala?Pro?Leu?Thr?Glu?Val?Pro?Glu?Glu

70 75 80 85

gag?cag?gcg?cac?ctc?gac?gct?gat?gat?tcc?aag?gaa?cgt?cgc?aat?agc 403

Glu?Gln?Ala?His?Leu?Asp?Ala?Asp?Asp?Ser?Lys?Glu?Arg?Arg?Asn?Ser

90 95 100

ctc?aac?cgc?ctg?ctg?ttc?ccg?aag?cca?acc?gaa?gag?ttc?ctc?gag?cac 451

Leu?Asn?Arg?Leu?Leu?Phe?Pro?Lys?Pro?Thr?Glu?Glu?Phe?Leu?Glu?His

105 110 115

cgt?cgc?cgc?ttc?ggc?aac?acc?tct?gcg?ctg?gat?gat?cgt?gaa?ttc?ttc 499

Arg?Arg?Arg?Phe?Gly?Asn?Thr?Ser?Ala?Leu?Asp?Asp?Arg?Glu?Phe?Phe

120 125 130

tac?ggc?ctg?gtc?gaa?ggc?cgc?gag?act?ttg?atc?cgc?ctg?cca?gat?gtg 547

Tyr?Gly?Leu?Val?Glu?Gly?Arg?Glu?Thr?Leu?Ile?Arg?Leu?Pro?Asp?Val

135 140 145

cgc?acc?cca?ctg?ctt?gtt?cgc?ctg?gat?gcg?atc?tct?gag?cca?gac?gat 595

Arg?Thr?Pro?Leu?Leu?Val?Arg?Leu?Asp?Ala?Ile?Ser?Glu?Pro?Asp?Asp

150 155 160 165

aag?ggt?atg?cgc?aat?gtt?gtg?gcc?aac?gtc?aac?ggc?cag?atc?cgc?cca 643

Lys?Gly?Met?Arg?Asn?Val?Val?Ala?Asn?Val?Asn?Gly?Gln?Ile?Arg?Pro

170 175 180

atg?cgt?gtg?cgt?gac?cgc?tcc?gtt?gag?tct?gtc?acc?gca?acc?gca?gaa 691

Met?Arg?Val?Arg?Asp?Arg?Ser?Val?Glu?Ser?Val?Thr?Ala?Thr?Ala?Glu

185 190 195

aag?gca?gat?tcc?tcc?aac?aag?ggc?cat?gtt?gct?gca?cca?ttc?gct?ggt 739

Lys?Ala?Asp?Ser?Ser?Asn?Lys?Gly?His?ValAla?Ala?Pro?Phe?Ala?Gly

200 205 210

gtt?gtc?acc?gtg?act?gtt?gct?gaa?ggt?gat?gag?gtc?aag?gct?gga?gat 787

Val?Val?Thr?Val?Thr?Val?Ala?Glu?Gly?Asp?Glu?Val?Lys?Ala?Gly?Asp

215 220 225

gca?gtc?gca?atc?atc?gag?gct?atg?aag?atg?gaa?gca?aca?atc?act?gct 835

Ala?Val?Ala?Ile?Ile?Glu?Ala?Met?Lys?Met?Glu?Ala?Thr?Ile?Thr?Ala

230 235 240 245

tct?gtt?gac?ggc?aaa?atc?gat?cgc?gtt?gtg?gtt?cct?gct?gca?acg?aag 883

Ser?Val?Asp?Gly?Lys?Ile?Asp?Arg?Val?Val?Val?Pro?Ala?Ala?Thr?Lys

250 255 260

gtg?gaa?ggt?ggc?gac?ttg?atc?gtc?gtc?gtt?tcc?taaacctttc?tgtaaaaagc?936

Val?Glu?Gly?Gly?Asp?Leu?Ile?Val?Val?Val?Ser

265 270

ccc 939

<210>112

<211>272

<212>PRT

＜213〉Corynebacterium glutamicum

<400>112

Met?Leu?Gly?Arg?Pro?Thr?Lys?Val?Thr?Pro?Ser?Ser?Lys?Val?Val?Gly

1 5 10 15

Asp?Leu?Ala?Leu?His?Leu?Val?Gly?Ala?Gly?Val?Asp?Pro?Ala?Asp?Phe

20 25 30

Ala?Ala?Asp?Pro?Gln?Lys?Tyr?Asp?Ile?Pro?Asp?Ser?Val?Ile?Ala?Phe

35 40 45

Leu?Arg?Gly?Glu?Leu?Gly?Asn?Pro?Pro?Gly?Gly?Trp?Pro?Glu?Pro?Leu

50 55 60

Arg?Thr?Arg?Ala?Leu?Glu?Gly?Arg?Ser?Glu?Gly?Lys?Ala?Pro?Leu?Thr

65 70 75 80

Glu?Val?Pro?Glu?Glu?Glu?Gln?Ala?His?Leu?Asp?Ala?Asp?Asp?Ser?Lys

85 90 95

Glu?Arg?Arg?Asn?Ser?Leu?Asn?Arg?Leu?Leu?Phe?Pro?Lys?Pro?Thr?Glu

100 105 110

Glu?Phe?Leu?Glu?His?Arg?Arg?Arg?Phe?Gly?Asn?Thr?Ser?Ala?Leu?Asp

115 120 125

Asp?Arg?Glu?Phe?Phe?Tyr?Gly?Leu?Val?Glu?Gly?Arg?Glu?Thr?Leu?Ile

130 135 140

Arg?Leu?Pro?Asp?Val?Arg?Thr?Pro?Leu?Leu?Val?Arg?Leu?Asp?Ala?Ile

145 150 155 160

Ser?Glu?Pro?Asp?Asp?Lys?Gly?Met?Arg?Asn?Val?Val?Ala?Asn?Val?Asn

165 170 175

Gly?Gln?Ile?Arg?Pro?Met?Arg?Val?Arg?Asp?Arg?Ser?Val?Glu?Ser?Val

180 185 190

Thr?Ala?Thr?Ala?Glu?Lys?Ala?Asp?Ser?Ser?Asn?Lys?Gly?His?Val?Ala

195 200 205

Ala?Pro?Phe?Ala?Gly?Val?Val?Thr?Val?Thr?Val?Ala?Glu?Gly?Asp?Glu

210 215 220

Val?Lys?Ala?Gly?Asp?Ala?Val?Ala?Ile?Ile?Glu?Ala?Met?Lys?Met?Glu

225 230 235 240

Ala?Thr?Ile?Thr?Ala?Ser?Val?Asp?Gly?Lys?Ile?Asp?Arg?Val?Val?Val

245 250 255

Pro?Ala?Ala?Thr?Lys?Val?Glu?Gly?Gly?Asp?Leu?Ile?Val?Val?Val?Ser

260 265 270

<210>113

<211>939

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(916)

<223>FRXA02326

<400>113

ccaggcggac?agttgtccaa?cctgcgtgca?caggccaccg?cactgggcct?tgcggatcgt?60

ttcgaactca?tcgaagacaa?ctacgcaagc?cgttaatgag?atg?ctg?gga?cgc?cca 115

Met?Leu?Gly?Arg?Pro

1 5

acc?aag?gtc?acc?cca?tcc?tcc?aag?gtt?gtt?ggc?gac?ctc?gca?ctc?cac 163

Thr?Lys?Val?Thr?Pro?Ser?Ser?Lys?Val?Val?Gly?Asp?Leu?Ala?Leu?His

10 15 20

ctc?gtt?ggt?gcg?ggt?gtg?gat?cca?gca?gac?ttt?gct?gcc?gat?cca?caa 211

Leu?Val?Gly?Ala?Gly?Val?Asp?Pro?Ala?Asp?Phe?Ala?Ala?Asp?Pro?Gln

25 30 35

aag?tac?gac?atc?cca?gac?tct?gtc?atc?gcg?ttc?ctg?cgc?ggc?gag?ctt 259

Lys?Tyr?Asp?Ile?Pro?Asp?Ser?Val?Ile?Ala?Phe?Leu?Arg?Gly?Glu?Leu

40 45 50

ggt?aac?cct?cca?ggt?ggc?tgg?cca?gag?cca?ctg?cgc?acc?cgc?gca?ctg 307

Gly?Asn?Pro?Pro?Gly?Gly?Trp?Pro?Glu?Pro?Leu?Arg?Thr?Arg?Ala?Leu

55 60 65

gaa?ggc?cgc?tcc?gaa?ggc?aag?gca?cct?ctg?acg?gaa?gtt?cct?gag?gaa 355

Glu?Gly?Arg?Ser?Glu?Gly?Lys?Ala?Pro?Leu?Thr?Glu?Val?Pro?Glu?Glu

70 75 80 85

gag?cag?gcg?cac?ctc?gac?gct?gat?gat?tcc?aag?gaa?cgt?cgc?aat?agc 403

Glu?Gln?Ala?His?Leu?Asp?Ala?Asp?Asp?Ser?Lys?Glu?Arg?Arg?Asn?Ser

90 95 100

ctc?aac?cgc?ctg?ctg?ttc?ccg?aag?cca?acc?gaa?gag?ttc?ctc?gag?cac 451

Leu?Asn?Arg?Leu?Leu?Phe?Pro?Lys?Pro?Thr?Glu?Glu?Phe?Leu?Glu?His

105 110 115

cgt?cgc?cgc?ttc?ggc?aac?acc?tct?gcg?ctg?gat?gat?cgt?gaa?ttc?ttc 499

Arg?Arg?Arg?Phe?Gly?Asn?Thr?Ser?Ala?Leu?Asp?Asp?Arg?Glu?Phe?Phe

120 125 130

tac?ggc?ctg?gtc?gaa?ggc?cgc?gag?act?ttg?atc?cgc?ctg?cca?gat?gtg 547

Tyr?Gly?Leu?Val?Glu?Gly?Arg?Glu?Thr?Leu?Ile?Arg?Leu?Pro?Asp?Val

135 140 145

cgc?acc?cca?ctg?ctt?gtt?cgc?ctg?gat?gcg?atc?tct?gag?cca?gac?gat 595

Arg?Thr?Pro?Leu?Leu?Val?Arg?Leu?Asp?Ala?Ile?Ser?Glu?Pro?Asp?Asp

150 155 160 165

aag?ggt?atg?cgc?aat?gtt?gtg?gcc?aac?gtc?aac?ggc?cag?atc?cgc?cca 643

Lys?Gly?Met?Arg?Asn?Val?Val?Ala?Asn?Val?Asn?Gly?Gln?Ile?Arg?Pro

170 175 180

atg?cgt?gtg?cgt?gac?cgc?tcc?gtt?gag?tct?gtc?acc?gca?acc?gca?gaa 691

Met?Arg?Val?Arg?Asp?Arg?Ser?Val?Glu?Ser?Val?Thr?Ala?Thr?Ala?Glu

185 190 195

aag?gca?gat?tcc?tcc?aac?aag?ggc?cat?gtt?gct?gca?cca?ttc?gct?ggt 739

Lys?Ala?Asp?Ser?Ser?Asn?Lys?Gly?His?Val?Ala?Ala?Pro?Phe?Ala?Gly

200 205 210

gtt?gtc?acc?gtg?act?gtt?gct?gaa?ggt?gat?gag?gtc?aag?gct?gga?gat 787

Val?Val?Thr?Val?Thr?Val?Ala?Glu?Gly?Asp?Glu?Val?Lys?Ala?Gly?Asp

215 220 225

gca?gtc?gca?atc?atc?gag?gct?atg?aag?atg?gaa?gca?aca?atc?act?gct 835

Ala?Val?Ala?Ile?Ile?Glu?Ala?Met?Lys?Met?Glu?Ala?Thr?Ile?Thr?Ala

230 235 240 245

tct?gtt?gac?ggc?aaa?atc?gat?cgc?gtt?gtg?gtt?cct?gct?gca?acg?aag 883

Ser?Val?Asp?Gly?Lys?Ile?Asp?Arg?Val?Val?Val?Pro?Ala?Ala?Thr?Lys

250 255 260

gtg?gaa?ggt?ggc?gac?ttg?atc?gtc?gtc?gtt?tcc?taaacctttc?tgtaaaaagc?936

Val?Glu?Gly?Gly?Asp?Leu?Ile?Val?Val?Val?Ser

265 270

ccc 939

<210>114

<211>272

<212>PRT

＜213〉Corynebacterium glutamicum

<400>114

Met?Leu?Gly?Arg?Pro?Thr?Lys?Val?Thr?Pro?Ser?Ser?Lys?Val?Val?Gly

1 5 10 15

Asp?Leu?Ala?Leu?His?Leu?Val?Gly?Ala?Gly?Val?Asp?Pro?Ala?Asp?Phe

20 25 30

Ala?Ala?Asp?Pro?Gln?Lys?Tyr?Asp?Ile?Pro?Asp?Ser?Val?Ile?Ala?Phe

35 40 45

Leu?Arg?Gly?Glu?Leu?Gly?Asn?Pro?Pro?Gly?Gly?Trp?Pro?Glu?Pro?Leu

50 55 60

Arg?Thr?Arg?Ala?Leu?Glu?Gly?Arg?Ser?Glu?Gly?Lys?Ala?Pro?Leu?Thr

65 70 75 80

Glu?Val?Pro?Glu?Glu?Glu?Gln?Ala?His?Leu?Asp?Ala?Asp?Asp?Ser?Lys

85 90 95

Glu?Arg?Arg?Asn?Ser?Leu?Asn?Arg?Leu?Leu?Phe?Pro?Lys?Pro?Thr?Glu

100 105 110

Glu?Phe?Leu?Glu?His?Arg?Arg?Arg?Phe?Gly?Asn?Thr?Ser?Ala?Leu?Asp

115 120 125

Asp?Arg?Glu?Phe?Phe?Tyr?Gly?Leu?Val?Glu?Gly?Arg?Glu?Thr?Leu?Ile

130 135 140

Arg?Leu?Pro?Asp?Val?Arg?Thr?Pro?Leu?Leu?Val?Arg?Leu?Asp?Ala?Ile

145 150 155 160

Ser?Glu?Pro?Asp?Asp?Lys?Gly?Met?Arg?Asn?Val?Val?Ala?Asn?Val?Asn

165 170 175

Gly?Gln?Ile?Arg?Pro?Met?Arg?Val?Arg?Asp?Arg?Ser?Val?Glu?Ser?Val

180 185 190

Thr?Ala?Thr?Ala?Glu?Lys?Ala?Asp?Ser?Ser?Asn?Lys?Gly?His?Val?Ala

195 200 205

Ala?Pro?Phe?Ala?Gly?Val?Val?Thr?Val?Thr?Val?Ala?Glu?Gly?Asp?Glu

210 215 220

Val?Lys?Ala?Gly?Asp?Ala?Val?Ala?Ile?Ile?Glu?Ala?Met?Lys?Met?Glu

225 230 235 240

Ala?Thr?Ile?Thr?Ala?Ser?Val?Asp?Gly?Lys?Ile?Asp?Arg?Val?Val?Val

245 250 255

Pro?Ala?Ala?Thr?Lys?Val?Glu?Gly?Gly?Asp?Leu?Ile?Val?Val?Val?Ser

260 265 270

<210>115

<211>1083

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1060)

<223>RXN02327

<400>115

accgctgaag?cagcttggcc?cagccgcgtt?tgctcgtgat?ctccgtgagc?aggacgcact?60

ggcagttact?gataccacct?tccgcgatgc?acaccagtct?ttg?ctt?gcg?acc?cga 115

Leu?Leu?Ala?Thr?Arg

1 5

gtc?cgc?tca?ttc?gca?ctg?aag?cct?gcg?gca?gag?gcc?gtc?gca?aag?ctg 163

Val?Arg?Ser?Phe?Ala?Leu?Lys?Pro?Ala?Ala?Glu?Ala?Val?Ala?Lys?Leu

10 15 20

act?cct?gag?ctt?ttg?tcc?gtg?gag?gcc?tgg?ggc?ggc?gcg?acc?tac?gat 211

Thr?Pro?Glu?Leu?Leu?Ser?Val?Glu?Ala?Trp?Gly?Gly?Ala?Thr?Tyr?Asp

25 30 35

gtg?gcg?atg?cgt?ttc?ctc?ttt?gag?gat?ccg?tgg?gac?agg?ctc?gac?gag 259

Val?Ala?Met?Arg?Phe?Leu?Phe?Glu?Asp?Pro?Trp?Asp?Arg?Leu?Asp?Glu

40 45 50

ctg?cgc?gag?gcg?atg?ccg?aat?gta?aac?att?cag?atg?ctg?ctt?cgc?ggc 307

Leu?Arg?Glu?Ala?Met?Pro?Asn?Val?Asn?Ile?Gln?Met?Leu?Leu?Arg?Gly

55 60 65

cgc?aac?acc?gtg?gga?tac?acc?ccg?tac?cca?gac?tcc?gtc?tgc?cgc?gcg 355

Arg?Asn?Thr?Val?Gly?Tyr?Thr?Pro?Tyr?Pro?Asp?Ser?Val?Cys?Arg?Ala

70 75 80 85

ttt?gtt?aag?gaa?gct?gcc?agc?tcc?ggc?gtg?gac?atc?ttc?cgc?atc?ttc 403

Phe?Val?Lys?Glu?Ala?Ala?Ser?Ser?Gly?Val?Asp?Ile?Phe?Arg?Ile?Phe

90 95 100

gac?gcg?ctt?aac?gac?gtc?tcc?cag?atg?cgt?cca?gca?atc?gac?gca?gtc 451

Asp?Ala?Leu?Asn?Asp?Val?Ser?Gln?Met?Arg?Pro?Ala?Ile?Asp?Ala?Val

105 110 115

ctg?gag?acc?aac?acc?gcg?gta?gcc?gag?gtg?gct?atg?gct?tat?tct?ggt 499

Leu?Glu?Thr?Asn?Thr?Ala?Val?Ala?Glu?Val?Ala?Met?Ala?Tyr?Ser?Gly

120 125 130

gat?ctc?tct?gat?cca?aat?gaa?aag?ctc?tac?acc?ctg?gat?tac?tac?cta 547

Asp?Leu?Ser?Asp?Pro?Asn?Glu?Lys?Leu?Tyr?Thr?Leu?Asp?Tyr?Tyr?Leu

135 140 145

aag?atg?gca?gag?gag?atc?gtc?aag?tct?ggc?gct?cac?atc?ttg?gcc?att 595

Lys?Met?Ala?Glu?Glu?Ile?Val?Lys?Ser?Gly?Ala?His?Ile?Leu?Ala?Ile

150 155 160 165

aag?gat?atg?gct?ggt?ctg?ctt?cgc?cca?gct?gcg?gta?acc?aag?ctg?gtc 643

Lys?Asp?Met?Ala?Gly?Leu?Leu?Arg?Pro?Ala?Ala?Val?Thr?Lys?Leu?Val

170 175 180

acc?gca?ctg?cgc?cgt?gaa?ttc?gat?ctg?cca?gtg?cac?gtg?cac?acc?cac 691

Thr?Ala?Leu?Arg?Arg?Glu?Phe?Asp?Leu?Pro?Val?His?Val?His?Thr?His

185 190 195

gac?act?gcg?ggt?ggc?cag?ctg?gca?acc?tac?ttt?gct?gca?gct?caa?gct 739

Asp?Thr?Ala?Gly?Gly?Gln?Leu?Ala?Thr?Tyr?Phe?Ala?Ala?Ala?Gln?Ala

200 205 210

ggt?gca?gat?gct?gtt?gac?ggt?gct?tcc?ggc?acc?act?gtc?tgg?cac?cac 787

Gly?Ala?Asp?Ala?Val?Asp?Gly?Ala?Ser?Gly?Thr?Thr?Val?Trp?His?His

215 220 225

ctc?cca?agc?cat?ccc?ttg?tct?gcc?att?gtt?gct?gca?ttc?gcg?cac?acc 835

Leu?Pro?Ser?His?Pro?Leu?Ser?Ala?Ile?Val?Ala?Ala?Phe?Ala?His?Thr

230 235 240 245

cgt?cgc?gat?acc?ggt?ttg?agc?ctc?gag?gct?gtt?tct?gac?ctc?gag?ccg 883

Arg?Arg?Asp?Thr?Gly?Leu?Ser?Leu?Glu?Ala?Val?Ser?Asp?Leu?Glu?Pro

250 255 260

tac?tgg?gaa?gca?gtg?cgc?gga?ctg?tac?ctg?cca?ttt?gag?tct?gga?acc 931

Tyr?Trp?Glu?Ala?Val?Arg?Gly?Leu?Tyr?Leu?Pro?Phe?Glu?Ser?Gly?Thr

265 270 275

cca?ggc?cca?acc?ggt?cgc?gtc?tac?cgc?cac?gaa?atc?cca?ggc?gga?cag 979

Pro?Gly?Pro?Thr?Gly?Arg?Val?Tyr?Arg?His?Glu?Ile?Pro?Gly?Gly?Gln

280 285 290

ttg?tcc?aac?ctg?cgt?gca?cag?gcc?acc?gca?ctg?ggc?ctt?gcg?gat?cgt 1027

Leu?Ser?Asn?Leu?Arg?Ala?Gln?Ala?Thr?Ala?Leu?Gly?Leu?Ala?Asp?Arg

295 300 305

ttc?gaa?ctc?atc?gaa?gac?aac?tac?gca?agc?cgt?taatgagatg?ctgggacgcc 1080

Phe?Glu?Leu?Ile?Glu?Asp?Asn?Tyr?Ala?Ser?Arg

310 315 320

caa 1083

<210>116

<211>320

<212>PRT

＜213〉Corynebacterium glutamicum

<400>116

Leu?Leu?Ala?Thr?Arg?Val?Arg?Ser?Phe?Ala?Leu?Lys?Pro?Ala?Ala?Glu

1 5 10 15

Ala?Val?Ala?Lys?Leu?Thr?Pro?Glu?Leu?Leu?Ser?Val?Glu?Ala?Trp?Gly

20 25 30

Gly?Ala?Thr?Tyr?Asp?Val?Ala?Met?Arg?Phe?Leu?Phe?Glu?Asp?Pro?Trp

35 40 45

Asp?Arg?Leu?Asp?Glu?Leu?Arg?Glu?Ala?Met?Pro?Asn?Val?Asn?Ile?Gln

50 55 60

Met?Leu?Leu?Arg?Gly?Arg?Asn?Thr?Val?Gly?Tyr?Thr?Pro?Tyr?Pro?Asp

65 70 75 80

Ser?Val?Cys?Arg?Ala?Phe?Val?Lys?Glu?Ala?Ala?Ser?Ser?Gly?Val?Asp

85 90 95

Ile?Phe?Arg?Ile?Phe?Asp?Ala?Leu?Asn?Asp?Val?Ser?Gln?Met?Arg?Pro

100 105 110

Ala?Ile?Asp?Ala?Val?Leu?Glu?Thr?Asn?Thr?Ala?Val?Ala?Glu?Val?Ala

115 120 125

Met?Ala?Tyr?Ser?Gly?Asp?Leu?Ser?Asp?Pro?Asn?Glu?Lys?Leu?Tyr?Thr

130 135 140

Leu?Asp?Tyr?Tyr?Leu?Lys?Met?Ala?Glu?Glu?Ile?Val?Lys?Ser?Gly?Ala

145 150 155 160

His?Ile?Leu?Ala?Ile?Lys?Asp?Met?Ala?Gly?Leu?Leu?Arg?Pro?Ala?Ala

165 170 175

Val?Thr?Lys?Leu?Val?Thr?Ala?Leu?Arg?Arg?Glu?Phe?Asp?Leu?Pro?Val

180 185 190

His?Val?His?Thr?His?Asp?Thr?Ala?Gly?Gly?Gln?Leu?Ala?Thr?Tyr?Phe

195 200 205

Ala?Ala?Ala?Gln?Ala?Gly?Ala?Asp?Ala?Val?Asp?Gly?Ala?Ser?Gly?Thr

210 215 220

Thr?Val?Trp?His?His?Leu?Pro?Ser?His?Pro?Leu?Ser?Ala?Ile?Val?Ala

225 230 235 240

Ala?Phe?Ala?His?Thr?Arg?Arg?Asp?Thr?Gly?Leu?Ser?Leu?Glu?Ala?Val

245 250 255

Ser?Asp?Leu?Glu?Pro?Tyr?Trp?Glu?Ala?Val?Arg?Gly?Leu?Tyr?Leu?Pro

260 265 270

Phe?Glu?Ser?Gly?Thr?Pro?Gly?Pro?Thr?Gly?Arg?Val?Tyr?Arg?His?Glu

275 280 285

Ile?Pro?Gly?Gly?Gln?Leu?Ser?Asn?Leu?Arg?Ala?Gln?Ala?Thr?Ala?Leu

290 295 300

Gly?Leu?Ala?Asp?Arg?Phe?Glu?Leu?Ile?Glu?Asp?Asn?Tyr?Ala?Ser?Arg

305 310 315 320

<210>117

<211>1083

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1060)

<223>FRXA02327

<400>117

accgctgaag?cagcttggcc?cagccgcgtt?tgctcgtgat?ctccgtgagc?aggacgcact?60

ggcagttact?gataccacct?tccgcgatgc?acaccagtct?ttg?ctt?gcg?acc?cga 115

Leu?Leu?Ala?Thr?Arg

1 5

gtc?cgc?tca?ttc?gca?ctg?aag?cct?gcg?gca?gag?gcc?gtc?gca?aag?ctg 163

Val?Arg?Ser?Phe?Ala?Leu?Lys?Pro?Ala?Ala?Glu?Ala?Val?Ala?Lys?Leu

10 15 20

act?cct?gag?ctt?ttg?tcc?gtg?gag?gcc?tgg?ggc?ggc?gcg?acc?tac?gat 211

Thr?Pro?Glu?Leu?Leu?Ser?Val?Glu?Ala?Trp?Gly?Gly?Ala?Thr?Tyr?Asp

25 30 35

gtg?gcg?atg?cgt?ttc?ctc?ttt?gag?gat?ccg?tgg?gac?agg?ctc?gac?gag 259

Val?Ala?Met?Arg?Phe?Leu?Phe?Glu?Asp?Pro?Trp?Asp?Arg?Leu?Asp?Glu

40 45 50

ctg?cgc?gag?gcg?atg?ccg?aat?gta?aac?att?cag?atg?ctg?ctt?cgc?ggc 307

Leu?Arg?Glu?Ala?Met?Pro?Asn?Val?Asn?Ile?Gln?Met?Leu?Leu?Arg?Gly

55 60 65

cgc?aac?acc?gtg?gga?tac?acc?ccg?tac?cca?gac?tcc?gtc?tgc?cgc?gcg 355

Arg?Asn?Thr?Val?Gly?Tyr?Thr?Pro?Tyr?Pro?Asp?Ser?Val?Cys?Arg?Ala

70 75 80 85

ttt?gtt?aag?gaa?gct?gcc?agc?tcc?ggc?gtg?gac?atc?ttc?cgc?atc?ttc 403

Phe?Val?Lys?Glu?Ala?Ala?Ser?Ser?Gly?Val?Asp?Ile?Phe?Arg?Ile?Phe

90 95 100

gac?gcg?ctt?aac?gac?gtc?tcc?cag?atg?cgt?cca?gca?atc?gac?gca?gtc 451

Asp?Ala?Leu?Asn?Asp?Val?Ser?Gln?Met?Arg?Pro?Ala?Ile?Asp?Ala?Val

105 110 115

ctg?gag?acc?aac?acc?gcg?gta?gcc?gag?gtg?gct?atg?gct?tat?tct?ggt 499

Leu?Glu?Thr?Asn?Thr?Ala?Val?Ala?Glu?Val?Ala?Met?Ala?Tyr?Ser?Gly

120 125 130

gat?ctc?tct?gat?cca?aat?gaa?aag?ctc?tac?acc?ctg?gat?tac?tac?cta 547

Asp?Leu?Ser?Asp?Pro?Asn?Glu?Lys?Leu?Tyr?Thr?Leu?Asp?Tyr?Tyr?Leu

135 140 145

aag?atg?gca?gag?gag?atc?gtc?aag?tct?ggc?gct?cac?atc?ttg?gcc?att 595

Lys?Met?Ala?Glu?Glu?Ile?Val?Lys?Ser?Gly?Ala?His?Ile?Leu?Ala?Ile

150 155 160 165

aag?gat?atg?gct?ggt?ctg?ctt?cgc?cca?gct?gcg?gta?acc?aag?ctg?gtc 643

Lys?Asp?Met?Ala?Gly?Leu?Leu?Arg?Pro?Ala?Ala?Val?Thr?Lys?Leu?Val

170 175 180

acc?gca?ctg?cgc?cgt?gaa?ttc?gat?ctg?cca?gtg?cac?gtg?cac?acc?cac 691

Thr?Ala?Leu?Arg?Arg?Glu?Phe?Asp?Leu?Pro?Val?His?Val?His?Thr?His

185 190 195

gac?act?gcg?ggt?ggc?cag?ctg?gca?acc?tac?ttt?gct?gca?gct?caa?gct 739

Asp?Thr?Ala?Gly?Gly?Gln?Leu?Ala?Thr?Tyr?Phe?Ala?Ala?Ala?Gln?Ala

200 205 210

ggt?gca?gat?gct?gtt?gac?ggt?gct?tcc?ggc?acc?act?gtc?tgg?cac?cac 787

Gly?Ala?Asp?Ala?Val?Asp?Gly?Ala?Ser?Gly?Thr?Thr?Val?Trp?His?His

215 220 225

ctc?cca?agc?cat?ccc?ttg?tct?gcc?att?gtt?gct?gca?ttc?gcg?cac?acc 835

Leu?Pro?Ser?His?Pro?Leu?Ser?Ala?Ile?Val?Ala?Ala?Phe?Ala?His?Thr

230 235 240 245

cgt?cgc?gat?acc?ggt?ttg?agc?ctc?gag?gct?gtt?tct?gac?ctc?gag?ccg 883

Arg?Arg?Asp?Thr?Gly?Leu?Ser?Leu?Glu?Ala?Val?Ser?Asp?Leu?Glu?Pro

250 255 260

tac?tgg?gaa?gca?gtg?cgc?gga?ctg?tac?ctg?cca?ttt?gag?tct?gga?acc 931

Tyr?Trp?Glu?Ala?Val?Arg?Gly?Leu?Tyr?Leu?Pro?Phe?Glu?Ser?Gly?Thr

265 270 275

cca?ggc?cca?acc?ggt?cgc?gtc?tac?cgc?cac?gaa?atc?cca?ggc?gga?cag 979

Pro?Gly?Pro?Thr?Gly?Arg?Val?Tyr?Arg?His?Glu?Ile?Pro?Gly?Gly?Gln

280 285 290

ttg?tcc?aac?ctg?cgt?gca?cag?gcc?acc?gca?ctg?ggc?ctt?gcg?gat?cgt 1027

Leu?Ser?Asn?Leu?Arg?Ala?Gln?Ala?Thr?Ala?Leu?Gly?Leu?Ala?Asp?Arg

295 300 305

ttc?gaa?ctc?atc?gaa?gac?aac?tac?gca?agc?cgt?taatgagatg?ctgggacgcc 1080

Phe?Glu?Leu?Ile?Glu?Asp?Asn?Tyr?Ala?Ser?Arg

310 315 320

caa 1083

<210>118

<211>320

<212>PRT

＜213〉Corynebacterium glutamicum

<400>118

Leu?Leu?Ala?Thr?Arg?Val?Arg?Ser?Phe?Ala?Leu?Lys?Pro?Ala?Ala?Glu

1 5 10 15

Ala?Val?Ala?Lys?Leu?Thr?Pro?Glu?Leu?Leu?Ser?Val?Glu?Ala?Trp?Gly

20 25 30

Gly?Ala?Thr?Tyr?Asp?Val?Ala?Met?Arg?Phe?Leu?Phe?Glu?Asp?Pro?Trp

35 40 45

Asp?Arg?Leu?Asp?Glu?Leu?Arg?Glu?Ala?Met?Pro?Asn?Val?Asn?Ile?Gln

50 55 60

Met?Leu?Leu?Arg?Gly?Arg?Asn?Thr?Val?Gly?Tyr?Thr?Pro?Tyr?Pro?Asp

65 70 75 80

Ser?Val?Cys?Arg?Ala?Phe?Val?Lys?Glu?Ala?Ala?Ser?Ser?Gly?Val?Asp

85 90 95

Ile?Phe?Arg?Ile?Phe?Asp?Ala?Leu?Asn?Asp?Val?Ser?Gln?Met?Arg?Pro

100 105 110

Ala?Ile?Asp?Ala?Val?Leu?Glu?Thr?Asn?Thr?Ala?Val?Ala?Glu?Val?Ala

115 120 125

Met?Ala?Tyr?Ser?Gly?Asp?Leu?Ser?Asp?Pro?Asn?Glu?Lys?Leu?Tyr?Thr

130 135 140

Leu?Asp?Tyr?Tyr?Leu?Lys?Met?Ala?Glu?Glu?Ile?Val?Lys?Ser?Gly?Ala

145 150 155 160

His?Ile?Leu?Ala?Ile?Lys?Asp?Met?Ala?Gly?Leu?Leu?Arg?Pro?Ala?Ala

165 170 175

Val?Thr?Lys?Leu?Val?Thr?Ala?Leu?Arg?Arg?Glu?Phe?Asp?Leu?Pro?Val

180 185 190

His?Val?His?Thr?His?Asp?Thr?Ala?Gly?Gly?Gln?Leu?Ala?Thr?Tyr?Phe

195 200 205

Ala?Ala?Ala?Gln?Ala?Gly?Ala?Asp?Ala?Val?Asp?Gly?Ala?Ser?Gly?Thr

210 215 220

Thr?Val?Trp?His?His?Leu?Pro?Ser?His?Pro?Leu?Ser?Ala?Ile?Val?Ala

225 230 235 240

Ala?Phe?Ala?His?Thr?Arg?Arg?Asp?Thr?Gly?Leu?Ser?Leu?Glu?Ala?Val

245 250 255

Ser?Asp?Leu?Glu?Pro?Tyr?Trp?Glu?Ala?Val?Arg?Gly?Leu?Tyr?Leu?Pro

260 265 270

Phe?Glu?Ser?Gly?Thr?Pro?Gly?Pro?Thr?Gly?Arg?Val?Tyr?Arg?His?Glu

275 280 285

Ile?Pro?Gly?Gly?Gln?Leu?Ser?Asn?Leu?Arg?Ala?Gln?Ala?Thr?Ala?Leu

290 295 300

Gly?Leu?Ala?Asp?Arg?Phe?Glu?Leu?Ile?Glu?Asp?Asn?Tyr?Ala?Ser?Arg

305 310 315 320

<210>119

<211>1719

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1696)

<223>RXN02328

<400>119

gaagtcgtgc?aggtcagggg?agtgttgccc?gaaaacattg?agaggaaaac?aaaaaccgat?60

gtttgattgg?gggaatcggg?ggttacgata?ctaggacgca?gtg?act?gct?atc?acc 115

Val?Thr?Ala?lle?Thr

1 5

ctt?ggc?ggt?ctc?ttg?ttg?aaa?gga?ata?att?act?cta?gtg?tcg?act?cac 163

Leu?Gly?Gly?Leu?Leu?Leu?Lys?Gly?Ile?Ile?Thr?Leu?Val?Ser?Thr?His

10 15 20

aca?tct?tca?acg?ctt?cca?gca?ttc?aaa?aag?atc?ttg?gta?gca?aac?cgc 211

Thr?Ser?Ser?Thr?Leu?Pro?Ala?Phe?Lys?Lys?Ile?Leu?Val?Ala?Asn?Arg

25 30 35

ggc?gaa?atc?gcg?gtc?cgt?gct?ttc?cgt?gca?gca?ctc?gaa?acc?ggt?gca 259

Gly?Glu?Ile?Ala?Val?Arg?Ala?Phe?Arg?Ala?Ala?Leu?Glu?Thr?Gly?Ala

40 45 50

gcc?acg?gta?gct?att?tac?ccc?cgt?gaa?gat?cgg?gga?tca?ttc?cac?cgc 307

Ala?Thr?Val?Ala?Ile?Tyr?Pro?Arg?Glu?Asp?Arg?Gly?Ser?Phe?His?Arg

55 60 65

tct?ttt?gct?tct?gaa?gct?gtc?cgc?att?ggt?acc?gaa?ggc?tca?cca?gtc 355

Ser?Phe?Ala?Ser?Glu?Ala?Val?Arg?Ile?Gly?Thr?Glu?Gly?Ser?Pro?Val

70 75 80 85

aag?gcg?tac?ctg?gac?atc?gat?gaa?att?atc?ggt?gca?gct?aaa?aaa?gtt 403

Lys?Ala?Tyr?Leu?Asp?Ile?Asp?Glu?Ile?Ile?Gly?Ala?Ala?Lys?Lys?Val

90 95 100

aaa?gca?gat?gcc?att?tac?ccg?gga?tac?ggc?ttc?ctg?tct?gaa?aat?gcc 451

Lys?Ala?Asp?Ala?Ile?Tyr?Pro?Gly?Tyr?Gly?Phe?Leu?Ser?Glu?Asn?Ala

105 110 115

cag?ctt?gcc?cgc?gag?tgt?gcg?gaa?aac?ggc?att?act?ttt?att?ggc?cca 499

Gln?Leu?Ala?Arg?Glu?Cys?Ala?Glu?Asn?Gly?Ile?Thr?Phe?Ile?Gly?Pro

120 125 130

acc?cca?gag?gtt?ctt?gat?ctc?acc?ggt?gat?aag?tct?cgc?gcg?gta?acc 547

Thr?Pro?Glu?Val?Leu?Asp?Leu?Thr?Gly?Asp?Lys?Ser?Arg?Ala?Val?Thr

135 140 145

gcc?gcg?aag?aag?gct?ggt?ctg?cca?gtt?ttg?gcg?gaa?tcc?acc?ccg?agc 595

Ala?Ala?Lys?Lys?Ala?Gly?Leu?Pro?Val?Leu?Ala?Glu?Ser?Thr?Pro?Ser

150 155 160 165

aaa?aac?atc?gat?gag?atc?gtt?aaa?agc?gct?gaa?ggc?cag?act?tac?ccc 643

Lys?Asn?Ile?Asp?Glu?Ile?Val?Lys?Ser?Ala?Glu?Gly?Gln?Thr?Tyr?Pro

170 175 180

atc?ttt?gtg?aag?gca?gtt?gcc?ggt?ggt?ggc?gga?cgc?ggt?atg?cgt?ttt 691

Ile?Phe?Val?Lys?Ala?Val?Ala?Gly?Gly?Gly?Gly?Arg?Gly?Met?Arg?Phe

185 190 195

gtt?gct?tca?cct?gat?gag?ctt?cgc?aaa?tta?gca?aca?gaa?gca?tct?cgt 739

Val?Ala?Ser?Pro?Asp?Glu?Leu?Arg?Lys?Leu?Ala?Thr?Glu?Ala?Ser?Arg

200 205 210

gaa?gct?gaa?gcg?gct?ttc?ggc?gat?ggc?gcg?gta?tat?gtc?gaa?cgt?gct 787

Glu?Ala?Glu?Ala?Ala?Phe?Gly?Asp?Gly?Ala?Val?Tyr?Val?Glu?Arg?Ala

215 220 225

gtg?att?aac?cct?cag?cat?att?gaa?gtg?cag?atc?ctt?ggc?gat?cac?act 835

Val?Ile?Asn?Pro?Gln?His?Ile?Glu?Val?Gln?Ile?Leu?Gly?Asp?His?Thr

230 235 240 245

gga?gaa?gtt?gta?cac?ctt?tat?gaa?cgt?gac?tgc?tca?ctg?cag?cgt?cgt 883

Gly?Glu?Val?Val?His?Leu?Tyr?Glu?Arg?Asp?Cys?Ser?Leu?Gln?Arg?Arg

250 255 260

cac?caa?aaa?gtt?gtc?gaa?att?gcg?cca?gca?cag?cat?ttg?gat?cca?gaa 931

His?Gln?Lys?Val?Val?Glu?Ile?Ala?Pro?Ala?Gln?His?Leu?Asp?Pro?Glu

265 270 275

ctg?cgt?gat?cgc?att?tgt?gcg?gat?gca?gta?aag?ttc?tgc?cgc?tcc?att 979

Leu?Arg?Asp?Arg?Ile?Cys?Ala?Asp?Ala?Val?Lys?Phe?Cys?Arg?Ser?Ile

280 285 290

ggt?tac?cag?ggc?gcg?gga?acc?gtg?gaa?ttc?ttg?gtc?gat?gaa?aag?ggc 1027

Gly?Tyr?Gln?Gly?Ala?Gly?Thr?Val?Glu?Phe?Leu?Val?Asp?Glu?Lys?Gly

295 300 305

aac?cac?gtc?ttc?atc?gaa?atg?aac?cca?cgt?atc?cag?gtt?gag?cac?acc 1075

Asn?His?Val?Phe?Ile?Glu?Met?Asn?Pro?Arg?Ile?Gln?Val?Glu?His?Thr

310 315 320 325

gtg?act?gaa?gaa?gtc?acc?gag?gtg?gac?ctg?gtg?aag?gcg?cag?atg?cgc 1123

Val?Thr?Glu?Glu?Val?Thr?Glu?Val?Asp?Leu?Val?Lys?Ala?Gln?Met?Arg

330 335 340

ttg?gct?gct?ggt?gca?acc?ttg?aag?gaa?ttg?ggt?ctg?acc?caa?gat?aag 1171

Leu?Ala?Ala?Gly?Ala?Thr?Leu?Lys?Glu?Leu?Gly?Leu?Thr?Gln?Asp?Lys

345 350 355

atc?aag?acc?cac?ggt?gca?gca?ctg?cag?tgc?cgc?atc?acc?acg?gaa?gat 1219

Ile?Lys?Thr?His?Gly?Ala?Ala?Leu?Gln?Cys?Arg?Ile?Thr?Thr?Glu?Asp

360 365 370

cca?aac?aac?ggc?ttc?cgc?cca?gat?acc?gga?act?atc?acc?gcg?tac?cgc 1267

Pro?Asn?Asn?Gly?Phe?Arg?Pro?Asp?Thr?Gly?Thr?Ile?Thr?Ala?Tyr?Arg

375 380 385

tca?cca?ggc?gga?gct?ggc?gtt?cgt?ctt?gac?ggt?gca?gct?cag?ctc?ggt 1315

Ser?Pro?Gly?Gly?Ala?Gly?Val?Arg?Leu?Asp?Gly?Ala?Ala?Gln?Leu?Gly

390 395 400 405

ggc?gaa?atc?acc?gca?cac?ttt?gac?tcc?atg?ctg?gtg?aaa?atg?acc?tgc 1363

Gly?Glu?Ile?Thr?Ala?His?Phe?Asp?Ser?Met?Leu?Val?Lys?Met?Thr?Cys

410 415 420

cgt?ggt?tcc?gac?ttt?gaa?act?gct?gtt?gct?cgt?gca?cag?cgc?gcg?ttg 1411

Arg?Gly?Ser?Asp?Phe?Glu?Thr?Ala?Val?Ala?Arg?Ala?Gln?Arg?Ala?Leu

425 430 435

gct?gag?ttc?acc?gtg?tct?ggt?gtt?gca?acc?aac?att?ggt?ttc?ttg?cgt 1459

Ala?Glu?Phe?Thr?Val?Ser?Gly?Val?Ala?Thr?Asn?Ile?Gly?Phe?Leu?Arg

440 445 450

gcg?ttg?ctg?cgg?gaa?gag?gac?ttc?act?tcc?aag?cgc?atc?gcc?acc?gga 1507

Ala?Leu?Leu?Arg?Glu?Glu?Asp?Phe?Thr?Ser?Lys?Arg?Ile?Ala?Thr?Gly

455 460 465

ttc?att?gcc?gat?cac?ccg?cac?ctc?ctt?cag?gct?cca?cct?gct?gat?gat 1555

Phe?Ile?Ala?Asp?His?Pro?His?Leu?Leu?Gln?Ala?Pro?Pro?Ala?Asp?Asp

470 475 480 485

gag?cag?gga?cgc?atc?ctg?gat?tac?ttg?gca?gat?gtc?acc?gtg?aac?aag 1603

Glu?Gln?Gly?Arg?Ile?Leu?Asp?Tyr?Leu?Ala?Asp?Val?Thr?Val?Asn?Lys

490 495 500

cct?cat?ggt?gtg?cgt?cca?aag?gat?gtt?gca?gct?cct?atc?gat?aag?ctg 1651

Pro?His?Gly?Val?Arg?Pro?Lys?Asp?Val?Ala?Ala?Pro?Ile?Asp?Lys?Leu

505 510 515

cct?aac?atc?aag?gat?ctg?cca?ctg?cca?cgc?ggt?tcc?cgt?gac?cgc 1696

Pro?Asn?Ile?Lys?Asp?Leu?Pro?Leu?Pro?Arg?Gly?Ser?Arg?Asp?Arg

520 525 530

tgaagcagct?tggcccagcc?gcg 1719

<210>120

<211>532

<212>PRT

＜213〉Corynebacterium glutamicum

<400>120

Val?Thr?Ala?Ile?Thr?Leu?Gly?Gly?Leu?Leu?Leu?Lys?Gly?Ile?Ile?Thr

1 5 10 15

Leu?Val?Ser?Thr?His?Thr?Ser?Ser?Thr?Leu?Pro?Ala?Phe?Lys?Lys?Ile

20 25 30

Leu?Val?Ala?Asn?Arg?Gly?Glu?Ile?Ala?Val?Arg?Ala?Phe?Arg?Ala?Ala

35 40 45

Leu?Glu?Thr?Gly?Ala?Ala?Thr?Val?Ala?Ile?Tyr?Pro?Arg?Glu?Asp?Arg

50 55 60

Gly?Ser?Phe?His?Arg?Ser?Phe?Ala?Ser?Glu?Ala?Val?Arg?Ile?Gly?Thr

65 70 75 80

Glu?Gly?Ser?Pro?Val?Lys?Ala?Tyr?Leu?Asp?Ile?Asp?Glu?Ile?Ile?Gly

85 90 95

Ala?Ala?Lys?Lys?Val?Lys?Ala?Asp?Ala?Ile?Tyr?Pro?Gly?Tyr?Gly?Phe

100 105 110

Leu?Ser?Glu?Asn?Ala?Gln?Leu?Ala?Arg?Glu?Cys?Ala?Glu?Asn?Gly?Ile

115 120 125

Thr?Phe?Ile?Gly?Pro?Thr?Pro?Glu?Val?Leu?Asp?Leu?Thr?Gly?Asp?Lys

130 135 140

Ser?Arg?Ala?Val?Thr?Ala?Ala?Lys?Lys?Ala?Gly?Leu?Pro?Val?Leu?Ala

145 150 155 160

Glu?Ser?Thr?Pro?Ser?Lys?Asn?Ile?Asp?Glu?Ile?Val?Lys?Ser?Ala?Glu

165 170 175

Gly?Gln?Thr?Tyr?Pro?Ile?Phe?Val?Lys?Ala?Val?Ala?Gly?Gly?Gly?Gly

180 185 190

Arg?Gly?Met?Arg?Phe?Val?Ala?Ser?Pro?Asp?Glu?Leu?Arg?Lys?Leu?Ala

195 200 205

Thr?Glu?Ala?Ser?Arg?Glu?Ala?Glu?Ala?Ala?Phe?Gly?Asp?Gly?Ala?Val

210 215 220

Tyr?Val?Glu?Arg?Ala?Val?Ile?Asn?Pro?Gln?His?Ile?Glu?Val?Gln?Ile

225 230 235 240

Leu?Gly?Asp?His?Thr?Gly?Glu?Val?Val?His?Leu?Tyr?Glu?Arg?Asp?Cys

245 250 255

Ser?Leu?Gln?Arg?Arg?His?Gln?Lys?Val?Val?Glu?Ile?Ala?Pro?Ala?Gln

260 265 270

His?Leu?Asp?Pro?Glu?Leu?Arg?Asp?Arg?Ile?Cys?Ala?Asp?Ala?Val?Lys

275 280 285

Phe?Cys?Arg?Ser?Ile?Gly?Tyr?Gln?Gly?Ala?Gly?Thr?Val?Glu?Phe?Leu

290 295 300

Val?Asp?Glu?Lys?Gly?Asn?His?Val?Phe?Ile?Glu?Met?Asn?Pro?Arg?Ile

305 310 315 320

Gln?Val?Glu?His?Thr?Val?Thr?Glu?Glu?Val?Thr?Glu?Val?Asp?Leu?Val

325 330 335

Lys?Ala?Gln?Met?Arg?Leu?Ala?Ala?Gly?Ala?Thr?Leu?Lys?Glu?Leu?Gly

340 345 350

Leu?Thr?Gln?Asp?Lys?Ile?Lys?Thr?His?Gly?Ala?Ala?Leu?Gln?Cys?Arg

355 360 365

Ile?Thr?Thr?Glu?Asp?Pro?Asn?Asn?Gly?Phe?Arg?Pro?Asp?Thr?Gly?Thr

370 375 380

Ile?Thr?Ala?Tyr?Arg?Ser?Pro?Gly?Gly?Ala?Gly?Val?Arg?Leu?Asp?Gly

385 390 395 400

Ala?Ala?Gln?Leu?Gly?Gly?Glu?Ile?Thr?Ala?His?Phe?Asp?Ser?Met?Leu

405 410 415

Val?Lys?Met?Thr?Cys?Arg?Gly?Ser?Asp?Phe?Glu?Thr?Ala?Val?Ala?Arg

420 425 430

Ala?Gln?Arg?Ala?Leu?Ala?Glu?Phe?Thr?Val?Ser?Gly?Val?Ala?Thr?Asn

435 440 445

Ile?Gly?Phe?Leu?Arg?Ala?Leu?Leu?Arg?Glu?Glu?Asp?Phe?Thr?Ser?Lys

450 455 460

Arg?Ile?Ala?Thr?Gly?Phe?Ile?Ala?Asp?His?Pro?His?Leu?Leu?Gln?Ala

465 470 475 480

Pro?Pro?Ala?Asp?Asp?Glu?Gln?Gly?Arg?Ile?Leu?Asp?Tyr?Leu?Ala?Asp

485 490 495

Val?Thr?Val?Asn?Lys?Pro?His?Gly?Val?Arg?Pro?Lys?Asp?Val?Ala?Ala

500 505 510

Pro?Ile?Asp?Lys?Leu?Pro?Asn?Ile?Lys?Asp?Leu?Pro?Leu?Pro?Arg?Gly

515 520 525

Ser?Arg?Asp?Arg

530

<210>121

<211>1406

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(1383)

<223>FRXA02328

<400>121

gct?tct?gaa?gct?gtc?cgc?att?ggt?acc?gaa?ggc?tca?cca?gtc?aag?gcg 48

Ala?Ser?Glu?Ala?Val?Arg?Ile?Gly?Thr?Glu?Gly?Ser?Pro?Val?Lys?Ala

1 5 10 15

tac?ctg?gac?atc?gat?gaa?att?atc?ggt?gca?gct?aaa?aaa?gtt?aaa?gca 96

Tyr?Leu?Asp?Ile?Asp?Glu?Ile?Ile?Gly?Ala?Ala?Lys?Lys?Val?Lys?Ala

20 25 30

gat?gcc?att?tac?ccg?gga?tac?ggc?ttc?ctg?tct?gaa?aat?gcc?cag?ctt 144

Asp?Ala?Ile?Tyr?Pro?Gly?Tyr?Gly?Phe?Leu?Ser?Glu?Asn?Ala?Gln?Leu

35 40 45

gcc?cgc?gag?tgt?gcg?gaa?aac?ggc?att?act?ttt?att?ggc?cca?acc?cca 192

Ala?Arg?Glu?Cys?Ala?Glu?Asn?Gly?Ile?Thr?Phe?Ile?Gly?Pro?Thr?Pro

50 55 60

gag?gtt?ctt?gat?ctc?acc?ggt?gat?aag?tct?cgc?gcg?gta?acc?gcc?gcg 240

Glu?Val?Leu?Asp?Leu?Thr?Gly?Asp?Lys?Ser?Arg?Ala?Val?Thr?Ala?Ala

65 70 75 80

aag?aag?gct?ggt?ctg?cca?gtt?ttg?gcg?gaa?tcc?acc?ccg?agc?aaa?aac 288

Lys?Lys?Ala?Gly?Leu?Pro?Val?Leu?Ala?Glu?Ser?Thr?Pro?Ser?Lys?Asn

85 90 95

atc?gat?gag?atc?gtt?aaa?agc?gct?gaa?ggc?cag?act?tac?ccc?atc?ttt 336

Ile?Asp?Glu?Ile?Val?Lys?Ser?Ala?Glu?Gly?Gln?Thr?Tyr?Pro?Ile?Phe

100 105 110

gtg?aag?gca?gtt?gcc?ggt?ggt?ggc?gga?cgc?ggt?atg?cgt?ttt?gtt?gct 384

Val?Lys?Ala?Val?Ala?Gly?Gly?Gly?Gly?Arg?Gly?Met?Arg?Phe?Val?Ala

115 120 125

tca?cct?gat?gag?ctt?cgc?aaa?tta?gca?aca?gaa?gca?tct?cgt?gaa?gct 432

Ser?Pro?Asp?Glu?Leu?Arg?Lys?Leu?Ala?Thr?Glu?Ala?Ser?Arg?Glu?Ala

130 135 140

gaa?gcg?gct?ttc?ggc?gat?ggc?gcg?gta?tat?gtc?gaa?cgt?gct?gtg?att 480

Glu?Ala?Ala?Phe?Gly?Asp?Gly?Ala?Val?Tyr?Val?Glu?Arg?Ala?Val?Ile

145 150 155 160

aac?cct?cag?cat?att?gaa?gtg?cag?atc?ctt?ggc?gat?cac?act?gga?gaa 528

Ash?Pro?Gln?His?Ile?Glu?Val?Gln?Ile?Leu?Gly?Asp?His?Thr?Gly?Glu

165 170 175

gtt?gta?cac?ctt?tat?gaa?cgt?gac?tgc?tca?ctg?cag?cgt?cgt?cac?caa 576

Val?Val?His?Leu?Tyr?Glu?Arg?Asp?Cys?Ser?Leu?Gln?Arg?Arg?His?Gln

180 185 190

aaa?gtt?gtc?gaa?att?gcg?cca?gca?cag?cat?ttg?gat?cca?gaa?ctg?cgt 624

Lys?Val?Val?Glu?Ile?Ala?Pro?Ala?Gln?His?Leu?Asp?Pro?Glu?Leu?Arg

195 200 205

gat?cgc?att?tgt?gcg?gat?gca?gta?aag?ttc?tgc?cgc?tcc?att?ggt?tac 672

Asp?Arg?Ile?Cys?Ala?Asp?Ala?Val?Lys?Phe?Cys?Arg?Ser?Ile?Gly?Tyr

210 215 220

cag?ggc?gcg?gga?acc?gtg?gaa?ttc?ttg?gtc?gat?gaa?aag?ggc?aac?cac 720

Gln?Gly?Ala?Gly?Thr?Val?Glu?Phe?Leu?Val?Asp?Glu?Lys?Gly?Asn?His

225 230 235 240

gtc?ttc?atc?gaa?atg?aac?cca?cgt?atc?cag?gtt?gag?cac?acc?gtg?act 768

Val?Phe?Ile?Glu?Met?Asn?Pro?Arg?Ile?Gln?Val?Glu?His?Thr?Val?Thr

245 250 255

gaa?gaa?gtc?acc?gag?gtg?gac?ctg?gtg?aag?gcg?cag?atg?cgc?ttg?gct 816

Glu?Glu?Val?Thr?Glu?Val?Asp?Leu?Val?Lys?Ala?Gln?Met?Arg?Leu?Ala

260 265 270

gct?ggt?gca?acc?ttg?aag?gaa?ttg?ggt?ctg?acc?caa?gat?aag?atc?aag 864

Ala?Gly?Ala?Thr?Leu?Lys?Glu?Leu?Gly?Leu?Thr?Gln?Asp?Lys?Ile?Lys

275 280 285

acc?cac?ggt?gca?gca?ctg?cag?tgc?cgc?atc?acc?acg?gaa?gat?cca?aac 912

Thr?His?Gly?Ala?Ala?Leu?Gln?Cys?Arg?Ile?Thr?Thr?Glu?Asp?Pro?Asn

290 295 300

aac?ggc?ttc?cgc?cca?gat?acc?gga?act?atc?acc?gcg?tac?cgc?tca?cca 960

Asn?Gly?Phe?Arg?Pro?Asp?Thr?Gly?Thr?Ile?Thr?Ala?Tyr?Arg?Ser?Pro

305 310 315 320

ggc?gga?gct?ggc?gtt?cgt?ctt?gac?ggt?gca?gct?cag?ctc?ggt?ggc?gaa 1008

Gly?Gly?Ala?Gly?Val?Arg?Leu?Asp?Gly?Ala?Ala?Gln?Leu?Gly?Gly?Glu

325 330 335

atc?acc?gca?cac?ttt?gac?tcc?atg?ctg?gtg?aaa?atg?acc?tgc?cgt?ggt 1056

Ile?Thr?Ala?His?Phe?Asp?Ser?Met?Leu?Val?Lys?Met?Thr?Cys?Arg?Gly

340 345 350

tcc?gac?ttt?gaa?act?gct?gtt?gct?cgt?gca?cag?cgc?gcg?ttg?gct?gag 1104

Ser?Asp?Phe?Glu?Thr?Ala?Val?Ala?Arg?Ala?Gln?Arg?Ala?Leu?Ala?Glu

355 360 365

ttc?acc?gtg?tct?ggt?gtt?gca?acc?aac?att?ggt?ttc?ttg?cgt?gcg?ttg 1152

Phe?Thr?Val?Ser?Gly?Val?Ala?Thr?Asn?Ile?Gly?Phe?Leu?Arg?Ala?Leu

370 375 380

ctg?cgg?gaa?gag?gac?ttc?act?tcc?aag?cgc?atc?gcc?acc?gga?ttc?att 1200

Leu?Arg?Glu?Glu?Asp?Phe?Thr?Ser?Lys?Arg?Ile?Ala?Thr?Gly?Phe?Ile

385 390 395 400

gcc?gat?cac?ccg?cac?ctc?ctt?cag?gct?cca?cct?gct?gat?gat?gag?cag 1248

Ala?Asp?His?Pro?His?Leu?Leu?Gln?Ala?Pro?Pro?Ala?Asp?Asp?Glu?Gln

405 410 415

gga?cgc?atc?ctg?gat?tac?ttg?gca?gat?gtc?acc?gtg?aac?aag?cct?cat 1296

Gly?Arg?Ile?Leu?Asp?Tyr?Leu?Ala?Asp?Val?Thr?Val?Asn?Lys?Pro?His

420 425 430

ggt?gtg?cgt?cca?aag?gat?gtt?gca?gct?cct?atc?gat?aag?ctg?cct?aac 1344

Gly?Val?Arg?Pro?Lys?Asp?Val?Ala?Ala?Pro?Ile?Asp?Lys?Leu?Pro?Asn

435 440 445

atc?aag?gat?ctg?cca?ctg?cca?cgc?ggt?tcc?cgt?gac?cgc?tgaagcagct 1393

Ile?Lys?Asp?Leu?Pro?Leu?Pro?Arg?Gly?Ser?Arg?Asp?Arg

450 455 460

tggcccagcc?gcg 1406

<210>122

<211>461

<212>PRT

＜213〉Corynebacterium glutamicum

<400>122

Ala?Ser?Glu?Ala?Val?Arg?Ile?Gly?Thr?Glu?Gly?Ser?Pro?Val?Lys?Ala

1 5 10 15

Tyr?Leu?Asp?Ile?Asp?Glu?Ile?Ile?Gly?Ala?Ala?Lys?Lys?Val?Lys?Ala

20 25 30

Asp?Ala?Ile?Tyr?Pro?Gly?Tyr?Gly?Phe?Leu?Ser?Glu?Asn?Ala?Gln?Leu

35 40 45

Ala?Arg?Glu?Cys?Ala?Glu?Asn?Gly?Ile?Thr?Phe?Ile?Gly?Pro?Thr?Pro

50 55 60

Glu?Val?Leu?Asp?Leu?Thr?Gly?Asp?Lys?Ser?Arg?Ala?Val?Thr?Ala?Ala

65 70 75 80

Lys?Lys?Ala?Gly?Leu?Pro?Val?Leu?Ala?Glu?Ser?Thr?Pro?Ser?Lys?Asn

85 90 95

Ile?Asp?Glu?Ile?Val?Lys?Ser?Ala?Glu?Gly?Gln?Thr?Tyr?Pro?Ile?Phe

100 105 110

Val?Lys?Ala?Val?Ala?Gly?Gly?Gly?Gly?Arg?Gly?Met?Arg?Phe?Val?Ala

115 120 125

Ser?Pro?Asp?Glu?Leu?Arg?Lys?Leu?Ala?Thr?Glu?Ala?Ser?Arg?Glu?Ala

130 135 140

Glu?Ala?Ala?Phe?Gly?Asp?Gly?Ala?Val?Tyr?Val?Glu?Arg?Ala?Val?Ile

145 150 155 160

Asn?Pro?Gln?His?Ile?Glu?Val?Gln?Ile?Leu?Gly?Asp?His?Thr?Gly?Glu

165 170 175

Val?Val?His?Leu?Tyr?Glu?Arg?Asp?Cys?Ser?Leu?Gln?Arg?Arg?His?Gln

180 185 190

Lys?Val?Val?Glu?Ile?Ala?Pro?Ala?Gln?His?Leu?Asp?Pro?Glu?Leu?Arg

195 200 205

Asp?Arg?Ile?Cys?Ala?Asp?Ala?Val?Lys?Phe?Cys?Arg?Ser?Ile?Gly?Tyr

210 215 220

Gln?Gly?Ala?Gly?Thr?Val?Glu?Phe?Leu?Val?Asp?Glu?Lys?Gly?Asn?His

225 230 235 240

Val?Phe?Ile?Glu?Met?Asn?Pro?Arg?Ile?Gln?Val?Glu?His?Thr?Val?Thr

245 250 255

Glu?Glu?Val?Thr?Glu?Val?Asp?Leu?Val?Lys?Ala?Gln?Met?Arg?Leu?Ala

260 265 270

Ala?Gly?Ala?Thr?Leu?Lys?Glu?Leu?Gly?Leu?Thr?Gln?Asp?Lys?Ile?Lys

275 280 285

Thr?His?Gly?Ala?Ala?Leu?Gln?Cys?Arg?Ile?Thr?Thr?Glu?Asp?Pro?Asn

290 295 300

Asn?Gly?Phe?Arg?Pro?Asp?Thr?Gly?Thr?Ile?Thr?Ala?Tyr?Arg?Ser?Pro

305 310 315 320

Gly?Gly?Ala?Gly?Val?Arg?Leu?Asp?Gly?Ala?Ala?Gln?Leu?Gly?Gly?Glu

325 330 335

Ile?Thr?Ala?His?Phe?Asp?Ser?Met?Leu?Val?Lys?Met?Thr?Cys?Arg?Gly

340 345 350

Ser?Asp?Phe?Glu?Thr?Ala?Val?Ala?Arg?Ala?Gln?Arg?Ala?Leu?Ala?Glu

355 360 365

Phe?Thr?Val?Ser?Gly?Val?Ala?Thr?Asn?Ile?Gly?Phe?Leu?Arg?Ala?Leu

370 375 380

Leu?Arg?Glu?Glu?Asp?Phe?Thr?Ser?Lys?Arg?Ile?Ala?Thr?Gly?Phe?Ile

385 390 395 400

Ala?Asp?His?Pro?His?Leu?Leu?Gln?Ala?Pro?Pro?Ala?Asp?Asp?Glu?Gln

405 410 415

Gly?Arg?Ile?Leu?Asp?Tyr?Leu?Ala?Asp?Val?Thr?Val?Asn?Lys?Pro?His

420 425 430

Gly?Val?Arg?Pro?Lys?Asp?Val?Ala?Ala?Pro?Ile?Asp?Lys?Leu?Pro?Asn

435 440 445

Ile?Lys?Asp?Leu?Pro?Leu?Pro?Arg?Gly?Ser?Arg?Asp?Arg

450 455 460

<210>123

<211>1347

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1324)

<223>RXN01048

<400>123

agctacagat?ttagctagtg?tttttgttcc?agaaccctaa?atgaggttct?acccttaaca?60

gagcttcccg?caaaaacacc?gattaacaag?gctaaatgat?atg?acc?atc?gac?ctg 115

Met?Thr?Ile?Asp?Leu

1 5

cag?cgt?tcc?acc?caa?aac?ctc?acc?cat?gag?gaa?atc?ttc?gag?gca?cac 163

Gln?Arg?Ser?Thr?Gln?Asn?Leu?Thr?His?Glu?Glu?Ile?Phe?Glu?Ala?His

10 15 20

gag?ggc?gga?aag?ctc?tcc?att?agt?tcc?act?cgt?ccg?ctc?cgc?gac?atg 211

Glu?Gly?Gly?Lys?Leu?Ser?Ile?Ser?Ser?Thr?Arg?Pro?Leu?Arg?Asp?Met

25 30 35

cgc?gat?ctt?tcc?ctt?gct?tac?acc?cct?ggt?gtt?gct?cag?gtt?tgt?gaa 259

Arg?Asp?Leu?Ser?Leu?Ala?Tyr?Thr?Pro?Gly?Val?Ala?Gln?Val?Cys?Glu

40 45 50

gca?atc?aag?gaa?gat?cca?gag?gtt?gcg?cgc?acc?cac?acg?ggc?att?gga 307

Ala?Ile?Lys?Glu?Asp?Pro?Glu?Val?Ala?Arg?Thr?His?Thr?Gly?Ile?Gly

55 60 65

aac?acc?gtc?gcg?gtt?att?tcc?gac?ggc?acc?gct?gtt?ctt?ggc?ctt?ggc 355

Asn?Thr?Val?Ala?Val?Ile?Ser?Asp?Gly?Thr?Ala?Val?Leu?Gly?Leu?Gly

70 75 80 85

gat?atc?gga?cct?cag?gcc?tcc?ctt?ccc?gtc?atg?gag?ggc?aag?gct?cag 403

Asp?Ile?Gly?Pro?Gln?Ala?Ser?Leu?Pro?Val?Met?Glu?Gly?Lys?Ala?Gln

90 95 100

ctg?ttt?agc?tct?ttc?gct?ggc?ctg?aag?gct?atc?cct?atc?gtt?ttg?gac 451

Leu?Phe?Ser?Ser?Phe?Ala?Gly?Leu?Lys?Ala?Ile?Pro?Ile?Val?Leu?Asp

105 110 115

gtt?cac?gat?gtt?gac?gct?ttg?gtt?gag?acc?atc?gca?gcc?atc?gcg?cct 499

Val?His?Asp?Val?Asp?Ala?Leu?Val?Glu?Thr?Ile?Ala?Ala?Ile?Ala?Pro

120 125 130

tct?ttc?ggt?gct?atc?aac?ttg?gag?gac?atc?tcc?gct?cct?cgt?tgc?ttc 547

Ser?Phe?Gly?Ala?Ile?Asn?Leu?Glu?Asp?Ile?Ser?Ala?Pro?Arg?Cys?Phe

135 140 145

gag?gtg?gag?cgc?cgc?ctc?atc?gag?cgt?ctc?gat?att?cca?gtt?atg?cac 595

Glu?Val?Glu?Arg?Arg?Leu?Ile?Glu?Arg?Leu?Asp?Ile?Pro?Val?Met?His

150 155 160 165

gat?gac?cag?cac?ggc?acc?gct?gtg?gtt?atc?ctc?gct?gcg?ctg?cgc?aac 643

Asp?Asp?Gln?His?Gly?Thr?Ala?Val?Val?Ile?Leu?Ala?Ala?Leu?Arg?Asn

170 175 180

tcc?ctg?aag?ctg?ctg?gat?cgc?aag?atc?gaa?gac?ctc?aag?att?gtt?att 691

Ser?Leu?Lys?Leu?Leu?Asp?Arg?Lys?Ile?Glu?Asp?Leu?Lys?Ile?Val?Ile

185 190 195

tcc?ggc?gca?ggc?gca?gcg?ggc?gtt?gca?gct?gta?gat?atg?ctg?acc?aac 739

Ser?Gly?Ala?Gly?Ala?Ala?Gly?Val?Ala?Ala?Val?Asp?Met?Leu?Thr?Asn

200 205 210

gct?gga?gca?acc?gac?atc?gtg?gtt?ctt?gat?tcc?cga?ggc?atc?atc?cac 787

Ala?Gly?Ala?Thr?Asp?Ile?Val?Val?Leu?Asp?Ser?Arg?Gly?Ile?Ile?His

215 220 225

gac?agc?cgt?gag?gat?ctt?tcc?cca?gtt?aag?gct?gct?ctt?gca?gag?aag 835

Asp?Ser?Arg?Glu?Asp?Leu?Ser?Pro?Val?Lys?Ala?Ala?Leu?Ala?Glu?Lys

230 235 240 245

acc?aac?cct?cgt?ggc?atc?agc?ggt?ggc?atc?aat?gag?gct?ttc?acc?ggc 883

Thr?Asn?Pro?Arg?Gly?Ile?Ser?Gly?Gly?Ile?Asn?Glu?Ala?Phe?Thr?Gly

250 255 260

gcg?gac?ctg?ttc?att?ggc?gtg?tcc?ggc?ggc?aac?atc?ggc?gag?gac?gct 931

Ala?Asp?Leu?Phe?Ile?Gly?Val?Ser?Gly?Gly?Asn?Ile?Gly?Glu?Asp?Ala

265 270 275

ctc?aaa?ctc?atg?gcc?ccg?gag?cca?atc?ctg?ttc?acc?ctg?gcg?aac?cca 979

Leu?Lys?Leu?Met?Ala?Pro?Glu?Pro?Ile?Leu?Phe?Thr?Leu?Ala?Asn?Pro

280 285 290

acc?cca?gag?atc?gat?cct?gag?ctg?tct?cag?aag?tac?ggc?gcc?atc?gtc 1027

Thr?Pro?Glu?Ile?Asp?Pro?Glu?Leu?Ser?Gln?Lys?Tyr?Gly?Ala?Ile?Val

295 300 305

gcg?acc?ggg?cgc?tct?gac?ctg?cct?aac?cag?atc?aac?aac?gtg?ctg?gcg 1075

Ala?Thr?Gly?Arg?Ser?Asp?Leu?Pro?Asn?Gln?Ile?Asn?Asn?Val?Leu?Ala

310 315 320 325

ttc?cca?gga?att?ttc?gcc?ggc?gct?ctc?gca?gcc?aag?gct?aag?aag?atc 1123

Phe?Pro?Gly?Ile?Phe?Ala?Gly?Ala?Leu?Ala?Ala?Lys?Ala?Lys?Lys?Ile

330 335 340

acc?ccc?gag?atg?aag?ctc?gcc?gct?cag?agg?caa?tcg?cag?aca?tcg?cag 1171

Thr?Pro?Glu?Met?Lys?Leu?Ala?Ala?Gln?Arg?Gln?Ser?Gln?Thr?Ser?Gln

345 350 355

ctg?agg?acc?tcg?agg?tcg?gcc?gca?tcg?tgc?cta?ccg?ccc?tgg?atc?ccc 1219

Leu?Arg?Thr?Ser?Arg?Ser?Ala?Ala?Ser?Cys?Leu?Pro?Pro?Trp?Ile?Pro

360 365 370

gcg?ttg?ccc?caa?cag?tca?agg?cag?ctg?tcc?agg?ccg?tcg?cca?aag?cgc 1267

Ala?Leu?Pro?Gln?Gln?Ser?Arg?Gln?Leu?Ser?Arg?Pro?Ser?Pro?Lys?Arg

375 380 385

aaa?acg?ctt?aaa?aat?ttg?ctt?atc?gac?gcc?tcc?ctc?ccc?gtc?gag?gcg 1315

Lys?Thr?Leu?Lys?Asn?Leu?Leu?Ile?Asp?Ala?Ser?Leu?Pro?Val?Glu?Ala

390 395 400 405

cca?ata?ttt?taagagcaaa?cttgaggccc?aca 1347

Pro?Ile?Phe

<210>124

<211>408

<212>PRT

＜213〉Corynebacterium glutamicum

<400>124

Met?Thr?Ile?Asp?Leu?Gln?Arg?Ser?Thr?Gln?Asn?Leu?Thr?His?Glu?Glu

1 5 10 15

Ile?Phe?Glu?Ala?His?Glu?Gly?Gly?Lys?Leu?Ser?Ile?Ser?Ser?Thr?Arg

20 25 30

Pro?Leu?Arg?Asp?Met?Arg?Asp?Leu?Ser?Leu?Ala?Tyr?Thr?Pro?Gly?Val

35 40 45

Ala?Gln?Val?Cys?Glu?Ala?Ile?Lys?Glu?Asp?Pro?Glu?Val?Ala?Arg?Thr

50 55 60

His?Thr?Gly?Ile?Gly?Asn?Thr?Val?Ala?Val?Ile?Ser?Asp?Gly?Thr?Ala

65 70 75 80

Val?Leu?Gly?Leu?Gly?Asp?Ile?Gly?Pro?Gln?Ala?Ser?Leu?Pro?Val?Met

85 90 95

Glu?Gly?Lys?Ala?Gln?Leu?Phe?Ser?Ser?Phe?Ala?Gly?Leu?Lys?Ala?Ile

100 105 110

Pro?Ile?Val?Leu?Asp?Val?His?Asp?Val?Asp?Ala?Leu?Val?Glu?Thr?Ile

115 120 125

Ala?Ala?Ile?Ala?Pro?Ser?Phe?Gly?Ala?Ile?Asn?Leu?Glu?Asp?Ile?Ser

130 135 140

Ala?Pro?Arg?Cys?Phe?Glu?Val?Glu?Arg?Arg?Leu?Ile?Glu?Arg?Leu?Asp

145 150 155 160

Ile?Pro?Val?Met?His?Asp?Asp?Gln?His?Gly?Thr?Ala?Val?Val?Ile?Leu

165 170 175

Ala?Ala?Leu?Arg?Asn?Ser?Leu?Lys?Leu?Leu?Asp?Arg?Lys?Ile?Glu?Asp

180 185 190

Leu?Lys?Ile?Val?Ile?Ser?Gly?Ala?Gly?Ala?Ala?Gly?Val?Ala?Ala?Val

195 200 205

Asp?Met?Leu?Thr?Asn?Ala?Gly?Ala?Thr?Asp?Ile?Val?Val?Leu?Asp?Ser

210 215 220

Arg?Gly?Ile?Ile?His?Asp?Ser?Arg?Glu?Asp?Leu?Ser?Pro?Val?Lys?Ala

225 230 235 240

Ala?Leu?Ala?Glu?Lys?Thr?Asn?Pro?Arg?Gly?Ile?Ser?Gly?Gly?Ile?Asn

245 250 255

Glu?Ala?Phe?Thr?Gly?Ala?Asp?Leu?Phe?Ile?Gly?Val?Ser?Gly?Gly?Asn

260 265 270

Ile?Gly?Glu?Asp?Ala?Leu?Lys?Leu?Met?Ala?Pro?Glu?Pro?Ile?Leu?Phe

275 280 285

Thr?Leu?Ala?Asn?Pro?Thr?Pro?Glu?Ile?Asp?Pro?Glu?Leu?Ser?Gln?Lys

290 295 300

Tyr?Gly?Ala?Ile?Val?Ala?Thr?Gly?Arg?Ser?Asp?Leu?Pro?Asn?Gln?Ile

305 310 315 320

Asn?Asn?Val?Leu?Ala?Phe?Pro?Gly?Ile?Phe?Ala?Gly?Ala?Leu?Ala?Ala

325 330 335

Lys?Ala?Lys?Lys?Ile?Thr?Pro?Glu?Met?Lys?Leu?Ala?Ala?Gln?Arg?Gln

340 345 350

Ser?Gln?Thr?Ser?Gln?Leu?Arg?Thr?Ser?Arg?Ser?Ala?Ala?Ser?Cys?Leu

355 360 365

Pro?Pro?Trp?Ile?Pro?Ala?Leu?Pro?Gln?Gln?Ser?Arg?Gln?Leu?Ser?Arg

370 375 380

Pro?Ser?Pro?Lys?Arg?Lys?Thr?Leu?Lys?Asn?Leu?Leu?Ile?Asp?Ala?Ser

385 390 395 400

Leu?Pro?Val?Glu?Ala?Pro?Ile?Phe

405

<210>125

<211>311

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(288)

<223>FRXA01048

<400>125

cgc?tct?gac?ttg?cct?aac?cag?atc?aac?aac?gtg?ctg?gcg?ttc?cca?gga 48

Arg?Ser?Asp?Leu?Pro?Asn?Gln?Ile?Asn?Asn?Val?Leu?Ala?Phe?Pro?Gly

1 5 10 15

att?ttc?gcc?ggc?gct?ctc?gca?gcc?aag?gct?aag?aag?atc?acc?ccc?gag 96

Ile?Phe?Ala?Gly?Ala?Leu?Ala?Ala?Lys?Ala?Lys?Lys?Ile?Thr?Pro?Glu

20 25 30

atg?aag?ctc?gcc?gct?cag?agg?caa?tcg?cag?aca?tcg?cag?ctg?agg?acc 144

Met?Lys?Leu?Ala?Ala?Gln?Arg?Gln?Ser?Gln?Thr?Ser?Gln?Leu?Arg?Thr

35 40 45

tcg?agg?tcg?gcc?gca?tcg?tgc?cta?ccg?ccc?tgg?atc?ccc?gcg?ttg?ccc 192

Ser?Arg?Ser?Ala?Ala?Ser?Cys?Leu?Pro?Pro?Trp?Ile?Pro?Ala?Leu?Pro

50 55 60

caa?cag?tca?agg?cag?ctg?tcc?agg?ccg?tcg?cca?aag?cgc?aaa?acg?ctt 240

Gln?Gln?Ser?Arg?Gln?Leu?Ser?Arg?Pro?Ser?Pro?Lys?Arg?Lys?Thr?Leu

65 70 75 80

aaa?aat?ttg?ctt?atc?gac?gcc?tcc?ctc?ccc?gtc?gag?gcg?cca?ata?ttt 288

Lys?Asn?Leu?Leu?Ile?Asp?Ala?Ser?Leu?Pro?Val?Glu?Ala?Pro?Ile?Phe

85 90 95

taagagcaaa?cttgaggccc?aca 311

<210>126

<211>96

<212>PRT

＜213〉Corynebacterium glutamicum

<400>126

Arg?Ser?Asp?Leu?Pro?Asn?Gln?Ile?Asn?Asn?Val?Leu?Ala?Phe?Pro?Gly

1 5 10 15

Ile?Phe?Ala?Gly?Ala?Leu?Ala?Ala?Lys?Ala?Lys?Lys?Ile?Thr?Pro?Glu

20 25 30

Met?Lys?Leu?Ala?Ala?Gln?Arg?Gln?Ser?Gln?Thr?Ser?Gln?Leu?Arg?Thr

35 40 45

Ser?Arg?Ser?Ala?Ala?Ser?Cys?Leu?Pro?Pro?Trp?Ile?Pro?Ala?Leu?Pro

50 55 60

Gln?Gln?Ser?Arg?Gln?Leu?Ser?Arg?Pro?Ser?Pro?Lys?Arg?Lys?Thr?Leu

65 70 75 80

Lys?Asn?Leu?Leu?Ile?Asp?Ala?Ser?Leu?Pro?Val?Glu?Ala?Pro?Ile?Phe

85 90 95

<210>127

<211>1063

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1063)

<223>FRXA00290

<400>127

agctacagat?ttagctagtg?tttttgttcc?agaaccctaa?atgaggttct?acccttaaca?60

gagcttcccg?caaaaacacc?gattaacaag?gctaaatgat?atg?acc?atc?gac?ctg 115

Met?Thr?Ile?Asp?Leu

1 5

cag?cgt?tcc?acc?caa?aac?ctc?acc?cat?gag?gaa?atc?ttc?gag?gca?cac 163

Gln?Arg?Ser?Thr?Gln?Asn?Leu?Thr?His?Glu?Glu?Ile?Phe?Glu?Ala?His

10 15 20

gag?ggc?gga?aag?ctc?tcc?att?agt?tcc?act?cgt?ccg?ctc?cgc?gac?atg 211

Glu?Gly?Gly?Lys?Leu?Ser?Ile?Ser?Ser?Thr?Arg?Pro?Leu?Arg?Asp?Met

25 30 35

cgc?gat?ctt?tcc?ctt?gct?tac?acc?cct?ggt?gtt?gct?cag?gtt?tgt?gaa 259

Arg?Asp?Leu?Ser?Leu?Ala?Tyr?Thr?Pro?Gly?Val?Ala?Gln?Val?Cys?Glu

40 45 50

gca?atc?aag?gaa?gat?cca?gag?gtt?gcg?cgc?acc?cac?acg?ggc?att?gga 307

Ala?Ile?Lys?Glu?Asp?Pro?Glu?Val?Ala?Arg?Thr?His?Thr?Gly?Ile?Gly

55 60 65

aac?acc?gtc?gcg?gtt?att?tcc?gac?ggc?acc?gct?gtt?ctt?ggc?ctt?ggc 355

Asn?Thr?Val?Ala?Val?Ile?Ser?Asp?Gly?Thr?Ala?Val?Leu?Gly?Leu?Gly

70 75 80 85

gat?atc?gga?cct?cag?gcc?tcc?ctt?ccc?gtc?atg?gag?ggc?aag?gct?cag 403

Asp?Ile?Gly?Pro?Gln?Ala?Ser?Leu?Pro?Val?Met?Glu?Gly?Lys?Ala?Gln

90 95 100

ctg?ttt?agc?tct?ttc?gct?ggc?ctg?aag?gct?atc?cct?atc?gtt?ttg?gac 451

Leu?Phe?Ser?Ser?Phe?Ala?Gly?Leu?Lys?Ala?Ile?Pro?Ile?Val?Leu?Asp

105 110 115

gtt?cac?gat?gtt?gac?gct?ttg?gtt?gag?acc?atc?gca?gcc?atc?gcg?cct 499

Val?His?Asp?Val?Asp?Ala?Leu?Val?Glu?Thr?Ile?Ala?Ala?Ile?Ala?Pro

120 125 130

tct?ttc?ggt?gct?atc?aac?ttg?gag?gac?atc?tcc?gct?cct?cgt?tgc?ttc 547

Ser?Phe?Gly?Ala?Ile?Asn?Leu?Glu?Asp?Ile?Ser?Ala?Pro?Arg?Cys?Phe

135 140 145

gag?gtg?gag?cgc?cgc?ctc?atc?gag?cgt?ctc?gat?att?cca?gtt?atg?cac 595

Glu?Val?Glu?Arg?Arg?Leu?Ile?Glu?Arg?Leu?Asp?Ile?Pro?Val?Met?His

150 155 160 165

gat?gac?cag?cac?ggc?acc?gct?gtg?gtt?atc?ctc?gct?gcg?ctg?cgc?aac 643

Asp?Asp?Gln?His?Gly?Thr?Ala?Val?Val?Ile?Leu?Ala?Ala?Leu?Arg?Asn

170 175 180

tcc?ctg?aag?ctg?ctg?gat?cgc?aag?atc?gaa?gac?ctc?aag?att?gtt?att 691

Ser?Leu?Lys?Leu?Leu?Asp?Arg?Lys?Ile?Glu?Asp?Leu?Lys?Ile?Val?Ile

185 190 195

tcc?ggc?gca?ggc?gca?gcg?ggc?gtt?gca?gct?gta?gat?atg?ctg?acc?aac 739

Ser?Gly?Ala?Gly?Ala?Ala?Gly?Val?Ala?Ala?Val?Asp?Met?Leu?Thr?Asn

200 205 210

gct?gga?gca?acc?gac?atc?gtg?gtt?ctt?gat?tcc?cga?ggc?atc?atc?cac 787

Ala?Gly?Ala?Thr?Asp?Ile?Val?Val?Leu?Asp?Ser?Arg?Gly?Ile?Ile?His

215 220 225

gac?agc?cgt?gag?gat?ctt?tcc?cca?gtt?aag?gct?gct?ctt?gca?gag?aag 835

Asp?Ser?Arg?Glu?Asp?Leu?Ser?Pro?Val?Lys?Ala?Ala?Leu?Ala?Glu?Lys

230 235 240 245

acc?aac?cct?cgt?ggc?atc?agc?ggt?ggc?atc?aat?gag?gct?ttc?acc?ggc 883

Thr?Asn?Pro?Arg?Gly?Ile?Ser?Gly?Gly?Ile?Asn?Glu?Ala?Phe?Thr?Gly

250 255 260

gcg?gac?ctg?ttc?att?ggc?gtg?tcc?ggc?ggc?aac?atc?ggc?gag?gac?gct 931

Ala?Asp?Leu?Phe?Ile?Gly?Val?Ser?Gly?Gly?Asn?Ile?Gly?Glu?Asp?Ala

265 270 275

ctc?aaa?ctc?atg?gcc?ccg?gag?cca?atc?ctg?ttc?acc?ctg?gcg?aac?cca 979

Leu?Lys?Leu?Met?Ala?Pro?Glu?Pro?Ile?Leu?Phe?Thr?Leu?Ala?Asn?Pro

280 285 290

acc?cca?gag?atc?gat?cct?gag?ctg?tct?cag?aag?tac?ggc?gcc?atc?gtc 1027

Thr?Pro?Glu?Ile?Asp?Pro?Glu?Leu?Ser?Gln?Lys?Tyr?Gly?Ala?Ile?Val

295 300 305

gcg?acc?ggg?ccg?gtc?ttg?acc?tgc?cta?acc?aga?tca 1063

Ala?Thr?Gly?Pro?Val?Leu?Thr?Cys?Leu?Thr?Arg?Ser

310 315 320

<210>128

<211>321

<212>PRT

＜213〉Corynebacterium glutamicum

<400>128

Met?Thr?Ile?Asp?Leu?Gln?Arg?Ser?Thr?Gln?Asn?Leu?Thr?His?Glu?Glu

1 5 10 15

Ile?Phe?Glu?Ala?His?Glu?Gly?Gly?Lys?Leu?Ser?Ile?Ser?Ser?Thr?Arg

20 25 30

Pro?Leu?Arg?Asp?Met?Arg?Asp?Leu?Ser?Leu?Ala?Tyr?Thr?Pro?Gly?Val

35 40 45

Ala?Gln?Val?Cys?Glu?Ala?Ile?Lys?Glu?Asp?Pro?Glu?Val?Ala?Arg?Thr

50 55 60

His?Thr?Gly?Ile?Gly?Asn?Thr?Val?Ala?Val?Ile?Ser?Asp?Gly?Thr?Ala

65 70 75 80

Val?Leu?Gly?Leu?Gly?Asp?Ile?Gly?Pro?Gln?Ala?Ser?Leu?Pro?Val?Met

85 90 95

Glu?Gly?Lys?Ala?Gln?Leu?Phe?Ser?Ser?Phe?Ala?Gly?Leu?Lys?Ala?Ile

100 105 110

Pro?Ile?Val?Leu?Asp?Val?His?Asp?Val?Asp?Ala?Leu?Val?Glu?Thr?Ile

115 120 125

Ala?Ala?Ile?Ala?Pro?Ser?Phe?Gly?Ala?Ile?Asn?Leu?Glu?Asp?Ile?Ser

130 135 140

Ala?Pro?Arg?Cys?Phe?Glu?Val?Glu?Arg?Arg?Leu?Ile?Glu?Arg?Leu?Asp

145 150 155 160

Ile?Pro?Val?Met?His?Asp?Asp?Gln?His?Gly?Thr?Ala?Val?Val?Ile?Leu

165 170 175

Ala?Ala?Leu?Arg?Asn?Ser?Leu?Lys?Leu?Leu?Asp?Arg?Lys?Ile?Glu?Asp

180 185 190

Leu?Lys?Ile?Val?Ile?Ser?Gly?Ala?Gly?Ala?Ala?Gly?Val?Ala?Ala?Val

195 200 205

Asp?Met?Leu?Thr?Asn?Ala?Gly?Ala?Thr?Asp?Ile?Val?Val?Leu?Asp?Ser

210 215 220

Arg?Gly?Ile?Ile?His?Asp?Ser?Arg?Glu?Asp?Leu?Ser?Pro?Val?Lys?Ala

225 230 235 240

Ala?Leu?Ala?Glu?Lys?Thr?Asn?Pro?Arg?Gly?Ile?Ser?Gly?Gly?Ile?Asn

245 250 255

Glu?Ala?Phe?Thr?Gly?Ala?Asp?Leu?Phe?Ile?Gly?Val?Ser?Gly?Gly?Asn

260 265 270

Ile?Gly?Glu?Asp?Ala?Leu?Lys?Leu?Met?Ala?Pro?Glu?Pro?Ile?Leu?Phe

275 280 285

Thr?Leu?Ala?Asn?Pro?Thr?Pro?Glu?Ile?Asp?Pro?Glu?Leu?Ser?Gln?Lys

290 295 300

Tyr?Gly?Ala?Ile?Val?Ala?Thr?Gly?Pro?Val?Leu?Thr?Cys?Leu?Thr?Arg

305 310 315 320

Ser

<210>129

<211>1065

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1042)

<223>RXA02694

<400>129

attaaaggtg?taacaaagga?atccgggcac?aagctcttgc?tgattttctg?agctgctttg?60

tgggttgtcc?ggttagggaa?atcaggaagt?gggatcgaaa?atg?aaa?gaa?acc?gtc 115

Met?Lys?Glu?Thr?Val

1 5

ggt?aac?aag?att?gtc?ctc?att?ggc?gca?gga?gat?gtt?gga?gtt?gca?tac 163

Gly?Asn?Lys?Ile?Val?Leu?Ile?Gly?Ala?Gly?Asp?Val?Gly?Val?Ala?Tyr

10 15 20

gca?tac?gca?ctg?atc?aac?cag?ggc?atg?gca?gat?cac?ctt?gcg?atc?atc 211

Ala?Tyr?Ala?Leu?Ile?Asn?Gln?Gly?Met?Ala?Asp?His?Leu?Ala?Ile?Ile

25 30 35

gac?atc?gat?gaa?aag?aaa?ctc?gaa?ggc?aac?gtc?atg?gac?tta?aac?cat 259

Asp?Ile?Asp?Glu?Lys?Lys?Leu?Glu?Gly?Asn?Val?Met?Asp?Leu?Asn?His

40 45 50

ggt?gtt?gtg?tgg?gcc?gat?tcc?cgc?acc?cgc?gtc?acc?aag?ggc?acc?tac 307

Gly?Val?Val?Trp?Ala?Asp?Ser?Arg?Thr?Arg?Val?Thr?Lys?Gly?Thr?Tyr

55 60 65

gct?gac?tgc?gaa?gac?gca?gcc?atg?gtt?gtc?att?tgt?gcc?ggc?gca?gcc 355

Ala?Asp?Cys?Glu?Asp?Ala?Ala?Met?Val?Val?Ile?Cys?Ala?Gly?Ala?Ala

70 75 80 85

caa?aag?cca?ggc?gag?acc?cgc?ctc?cag?ctg?gtg?gac?aaa?aac?gtc?aag 403

Gln?Lys?Pro?Gly?Glu?Thr?Arg?Leu?Gln?Leu?Val?Asp?Lys?Asn?Val?Lys

90 95 100

att?atg?aaa?tcc?atc?gtc?ggc?gat?gtc?atg?gac?agc?gga?ttc?gac?ggc 451

Ile?Met?Lys?Ser?Ile?Val?Gly?Asp?Val?Met?Asp?Ser?Gly?Phe?Asp?Gly

105 110 115

atc?ttc?ctc?gtg?gcg?tcc?aac?cca?gtg?gat?atc?ctg?acc?tac?gca?gtg 499

Ile?Phe?Leu?Val?Ala?Ser?Asn?Pro?Val?Asp?Ile?Leu?Thr?Tyr?Ala?Val

120 125 130

tgg?aaa?ttc?tcc?ggc?ttg?gaa?tgg?aac?cgc?gtg?atc?ggc?tcc?gga?act 547

Trp?Lys?Phe?Ser?Gly?Leu?Glu?Trp?Asn?Arg?Val?Ile?Gly?Ser?Gly?Thr

135 140 145

gtc?ctg?gac?tcc?gct?cga?ttc?cgc?tac?atg?ctg?ggc?gaa?ctc?tac?gaa 595

Val?Leu?Asp?Ser?Ala?Arg?Phe?Arg?Tyr?Met?Leu?Gly?Glu?Leu?Tyr?Glu

150 155 160 165

gtg?gca?cca?agc?tcc?gtc?cac?gcc?tac?atc?atc?ggc?gaa?cac?ggc?gac 643

Val?Ala?Pro?Ser?Ser?Val?His?Ala?Tyr?Ile?Ile?Gly?Glu?His?Gly?Asp

170 175 180

act?gaa?ctt?cca?gtc?ctg?tcc?tcc?gcg?acc?atc?gca?ggc?gta?tcg?ctt 691

Thr?Glu?Leu?Pro?Val?Leu?Ser?Ser?Ala?Thr?Ile?Ala?Gly?Val?Ser?Leu

185 190 195

agc?cga?atg?ctg?gac?aaa?gac?cca?gag?ctt?gag?ggc?cgt?cta?gag?aaa 739

Ser?Arg?Met?Leu?Asp?Lys?Asp?Pro?Glu?Leu?Glu?Gly?Arg?Leu?Glu?Lys

200 205 210

att?ttc?gaa?gac?acc?cgc?gac?gct?gcc?tat?cac?att?atc?gac?gcc?aag 787

Ile?Phe?Glu?Asp?Thr?Arg?Asp?Ala?Ala?Tyr?His?Ile?Ile?Asp?Ala?Lys

215 220 225

ggc?tcc?act?tcc?tac?ggc?atc?ggc?atg?ggt?ctt?gct?cgc?atc?acc?cgc 835

Gly?Ser?Thr?Ser?Tyr?Gly?Ile?Gly?Met?Gly?Leu?Ala?Arg?Ile?Thr?Arg

230 235 240 245

gca?atc?cta?cag?aac?caa?gac?gtt?gca?gtc?cca?gtc?tct?gca?ctg?ctc 883

Ala?Ile?Leu?Gln?Asn?Gln?Asp?Val?Ala?Val?Pro?Val?Ser?Ala?Leu?Leu

250 255 260

cac?ggt?gaa?tac?ggt?gag?gaa?gac?atc?tac?atc?ggc?acc?cca?gct?gtg 931

His?Gly?Glu?Tyr?Gly?Glu?Glu?Asp?Ile?Tyr?Ile?Gly?Thr?Pro?Ala?Val

265 270 275

gtg?aac?cgc?cga?ggc?atc?cgc?cgc?gtt?gtc?gaa?cta?gaa?atc?acc?gac 979

Val?Asn?Arg?Arg?Gly?Ile?Arg?Arg?Val?Val?Glu?Leu?Glu?Ile?Thr?Asp

280 285 290

cac?gag?atg?gaa?cgc?ttc?aag?cat?tcc?gca?aat?acc?ctg?cgc?gaa?att 1027

His?Glu?Met?Glu?Arg?Phe?Lys?His?Ser?Ala?Asn?Thr?Leu?Arg?Glu?Ile

295 300 305

cag?aag?cag?ttc?ttc?taaatctttg?gcgcctagtt?ggc 1065

Gln?Lys?Gln?Phe?Phe

310

<210>130

<211>314

<212>PRT

＜213〉Corynebacterium glutamicum

<400>130

Met?Lys?Glu?Thr?Val?Gly?Asn?Lys?Ile?Val?Leu?Ile?Gly?Ala?Gly?Asp

1 5 10 15

Val?Gly?Val?Ala?Tyr?Ala?Tyr?Ala?Leu?Ile?Asn?Gln?Gly?Met?Ala?Asp

20 25 30

His?Leu?Ala?Ile?Ile?Asp?Ile?Asp?Glu?Lys?Lys?Leu?Glu?Gly?Asn?Val

35 40 45

Met?Asp?Leu?Asn?His?Gly?Val?Val?Trp?Ala?Asp?Ser?Arg?Thr?Arg?Val

50 55 60

Thr?Lys?Gly?Thr?Tyr?Ala?Asp?Cys?Glu?Asp?Ala?Ala?Met?Val?Val?Ile

65 70 75 80

Cys?Ala?Gly?Ala?Ala?Gln?Lys?Pro?Gly?Glu?Thr?Arg?Leu?Gln?Leu?Val

85 90 95

Asp?Lys?Asn?Val?Lys?Ile?Met?Lys?Ser?Ile?Val?Gly?Asp?Val?Met?Asp

100 105 110

Ser?Gly?Phe?Asp?Gly?Ile?Phe?Leu?Val?Ala?Ser?Asn?Pro?Val?Asp?Ile

115 120 125

Leu?Thr?Tyr?Ala?Val?Trp?Lys?Phe?Ser?Gly?Leu?Glu?Trp?Asn?Arg?Val

130 135 140

Ile?Gly?Ser?Gly?Thr?Val?Leu?Asp?Ser?Ala?Arg?Phe?Arg?Tyr?Met?Leu

145 150 155 160

Gly?Glu?Leu?Tyr?Glu?Val?Ala?Pro?Ser?Ser?Val?His?Ala?Tyr?Ile?Ile

165 170 175

Gly?Glu?His?Gly?Asp?Thr?Glu?Leu?Pro?Val?Leu?Ser?Ser?Ala?Thr?Ile

180 185 190

Ala?Gly?Val?Ser?Leu?Ser?Arg?Met?Leu?Asp?Lys?Asp?Pro?Glu?Leu?Glu

195 200 205

Gly?Arg?Leu?Glu?Lys?Ile?Phe?Glu?Asp?Thr?Arg?Asp?Ala?Ala?Tyr?His

210 215 220

Ile?Ile?Asp?Ala?Lys?Gly?Ser?Thr?Ser?Tyr?Gly?Ile?Gly?Met?Gly?Leu

225 230 235 240

Ala?Arg?Ile?Thr?Arg?Ala?Ile?Leu?Gln?Asn?Gln?Asp?Val?Ala?Val?Pro

245 250 255

Val?Ser?Ala?Leu?Leu?His?Gly?Glu?Tyr?Gly?Glu?Glu?Asp?Ile?Tyr?Ile

260 265 270

Gly?Thr?Pro?Ala?Val?Val?Asn?Arg?Arg?Gly?Ile?Arg?Arg?Val?Val?Glu

275 280 285

Leu?Glu?Ile?Thr?Asp?His?Glu?Met?Glu?Arg?Phe?Lys?His?Ser?Ala?Asn

290 295 300

Thr?Leu?Arg?Glu?Ile?Gln?Lys?Gln?Phe?Phe

305 310

<210>131

<211>2967

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(2944)

<223>RXN00296

<400>131

tttttgttgg?catgtctgac?attatcgcac?aattcaccac?agtaaccggt?aacatgttac?60

tcaaagcccg?cttggatcga?atttcacaaa?aggacccacc?atg?act?cac?acc?atc 115

Met?Thr?His?Thr?Ile

1 5

aaa?ttc?aac?aga?ctc?gac?cca?gaa?gta?ttt?agc?cag?cat?tct?cgc?gcg 163

Lys?Phe?Asn?Arg?Leu?Asp?Pro?Glu?Val?Phe?Ser?Gln?His?Ser?Arg?Ala

10 15 20

aag?ctg?cgc?acg?gat?atg?aca?acc?cgt?gca?gca?tat?tct?tct?gat?gca 211

Lys?Leu?Arg?Thr?Asp?Met?Thr?Thr?Arg?Ala?Ala?Tyr?Ser?Ser?Asp?Ala

25 30 35

gga?att?ttt?aga?cgc?gtc?cct?gca?gct?gta?gct?gaa?cca?gaa?aat?gtg 259

Gly?Ile?Phe?Arg?Arg?Val?Pro?Ala?Ala?Val?Ala?Glu?Pro?Glu?Asn?Val

40 45 50

gaa?caa?att?cgt?gat?gcc?att?gct?gtt?gcg?gtg?gca?cga?ggg?tgg?tct 307

Glu?Gln?Ile?Arg?Asp?Ala?Ile?Ala?Val?Ala?Val?Ala?Arg?Gly?Trp?Ser

55 60 65

gtt?gtt?ggg?cgc?ggt?gga?gga?agc?tcg?gtt?gct?gga?aat?gcg?atc?ggt 355

Val?Val?Gly?Arg?Gly?Gly?Gly?Ser?Ser?Val?Ala?Gly?Asn?Ala?Ile?Gly

70 75 80 85

gaa?ggt?ttg?atc?atc?gat?acg?tca?cgc?tat?ttc?aac?cgc?att?tta?gat 403

Glu?Gly?Leu?Ile?Ile?Asp?Thr?Ser?Arg?Tyr?Phe?Asn?Arg?Ile?Leu?Asp

90 95 100

att?gat?cca?gtt?gca?caa?act?gca?gtt?gtg?gaa?ccc?ggt?gtg?gtg?tgt 451

Ile?Asp?Pro?Val?Ala?Gln?Thr?Ala?Val?Val?Glu?Pro?Gly?Val?Val?Cys

105 110 115

gat?gcc?ttg?cgc?gat?gca?gcc?gca?gaa?ttc?gga?tta?act?tac?ggc?ccg 499

Asp?Ala?Leu?Arg?Asp?Ala?Ala?Ala?Glu?Phe?Gly?Leu?Thr?Tyr?Gly?Pro

120 125 130

gat?cct?tcc?acg?cat?tcc?cgg?tgc?acg?atc?ggt?ggc?atg?gtt?gcc?aac 547

Asp?Pro?Ser?Thr?His?Ser?Arg?Cys?Thr?Ile?Gly?Gly?Met?Val?Ala?Asn

135 140 145

aat?gcg?tgt?ggt?tca?cac?tcg?gtt?gca?ttc?ggt?aca?gct?gcg?gaa?aat 595

Asn?Ala?Cys?Gly?Ser?His?Ser?Val?Ala?Phe?Gly?Thr?Ala?Ala?Glu?Asn

150 155 160 165

ctc?gtg?gat?gtc?acg?ctc?atg?ctc?agc?gat?ggc?cga?gaa?gtc?act?gtg 643

Leu?Val?Asp?Val?Thr?Leu?Met?Leu?Ser?Asp?Gly?Arg?Glu?Val?Thr?Val

170 175 180

aca?aaa?gat?ggc?tgc?gat?gat?gct?gag?atc?aat?cag?aag?ctc?acc?gac 691

Thr?Lys?Asp?Gly?Cys?Asp?Asp?Ala?Glu?Ile?Asn?Gln?Lys?Leu?Thr?Asp

185 190 195

tta?gcg?tcc?aag?aat?cag?gac?ctt?att?agt?aaa?gaa?ctg?ggt?cgt?ttc 739

Leu?Ala?Ser?Lys?Asn?Gln?Asp?Leu?Ile?Ser?Lys?Glu?Leu?Gly?Arg?Phe

200 205 210

cct?cgc?caa?gtg?tcg?ggc?tac?ggt?ttg?cat?tat?ctt?gcc?cac?gac?atg 787

Pro?Arg?Gln?Val?Ser?Gly?Tyr?Gly?Leu?His?Tyr?Leu?Ala?His?Asp?Met

215 220 225

gcc?aaa?gca?atg?gcg?ggc?acc?gag?gga?acc?att?gga?atc?att?act?cgg 835

Ala?Lys?Ala?Met?Ala?Gly?Thr?Glu?Gly?Thr?Ile?Gly?Ile?Ile?Thr?Arg

230 235 240 245

ttg?acg?gtg?aag?ttg?gtt?cca?aca?ccc?aaa?gtg?aaa?gcg?ctt?gct?gtc 883

Leu?Thr?Val?Lys?Leu?Val?Pro?Thr?Pro?Lys?Val?Lys?Ala?Leu?Ala?Val

250 255 260

ctg?gct?ttc?gac?acg?gtt?ttt?gac?gcc?gcc?cga?gca?gcc?gcc?aaa?ttg 931

Leu?Ala?Phe?Asp?Thr?Val?Phe?Asp?Ala?Ala?Arg?Ala?Ala?Ala?Lys?Leu

265 270 275

cga?ctg?cct?ggg?gta?gca?acc?att?gaa?ggc?atg?ggc?gga?gat?ctc?ctc 979

Arg?Leu?Pro?Gly?Val?Ala?Thr?Ile?Glu?Gly?Met?Gly?Gly?Asp?Leu?Leu

280 285 290

gct?gcg?ctg?cgc?agt?aaa?cag?gga?caa?tca?gaa?gct?ggg?cag?aat?ctt 1027

Ala?Ala?Leu?Arg?Ser?Lys?Gln?Gly?Gln?Ser?Glu?Ala?Gly?Gln?Asn?Leu

295 300 305

cca?gga?aac?cgc?atc?ggc?att?gaa?gcc?ggc?gga?tgg?ttg?tac?tgc?gag 1075

Pro?Gly?Asn?Arg?Ile?Gly?Ile?Glu?Ala?Gly?Gly?Trp?Leu?Tyr?Cys?Glu

310 315 320 325

aca?gga?agt?gac?acc?ctg?cag?gcc?gcg?gta?caa?gcc?gcc?gag?gaa?gtc 1123

Thr?Gly?Ser?Asp?Thr?Leu?Gln?Ala?Ala?Val?Gln?Ala?Ala?Glu?Glu?Val

330 335 340

gca?acc?gcc?gtt?gac?acc?att?gat?tac?gtg?gtc?gtg?tct?gag?cct?tct 1171

Ala?Thr?Ala?Val?Asp?Thr?Ile?Asp?Tyr?Val?Val?Val?Ser?Glu?Pro?Ser

345 350 355

gaa?atg?cgg?gaa?ttg?tgg?cgc?atc?cgt?gaa?tcc?tcg?gcg?ggc?att?gtc 1219

Glu?Met?Arg?Glu?Leu?Trp?Arg?Ile?Arg?Glu?Ser?Ser?Ala?Gly?Ile?Val

360 365 370

acg?cgc?tta?gct?gat?ggt?ggg?gaa?gcg?tgg?ccg?aat?tgg?gaa?gac?tcg 1267

Thr?Arg?Leu?Ala?Asp?Gly?Gly?Glu?Ala?Trp?Pro?Asn?Trp?Glu?Asp?Ser

375 380 385

gcg?gtg?cct?cca?gag?aat?tta?gct?gat?tat?ctc?cgc?gat?ctt?tat?gcg 1315

Ala?Val?Pro?Pro?Glu?Asn?Leu?Ala?Asp?Tyr?Leu?Arg?Asp?Leu?Tyr?Ala

390 395 400 405

ctg?atg?gat?aag?ttc?gat?tac?cag?ggt?att?cca?ttt?gga?cac?ttt?gga 1363

Leu?Met?Asp?Lys?Phe?Asp?Tyr?Gln?Gly?Ile?Pro?Phe?Gly?His?Phe?Gly

410 415 420

gaa?ggc?tgc?gtc?cac?gtt?cgc?atc?agt?ttt?gat?ttc?tct?acc?aag?gaa 1411

Glu?Gly?Cys?Val?His?Val?Arg?Ile?Ser?Phe?Asp?Phe?Ser?Thr?Lys?Glu

425 430 435

ggc?ctg?aag?aaa?ttc?gag?gcg?ttc?atg?aat?gaa?gcc?tcc?acc?ttg?gtg 1459

Gly?Leu?Lys?Lys?Phe?Glu?Ala?Phe?Met?Asn?Glu?Ala?Ser?Thr?Leu?Val

440 445 450

gcg?tct?tat?ggt?ggc?agc?ctc?tcg?ggc?gag?cat?gga?gac?ggt?cgc?gcc 1507

Ala?Ser?Tyr?Gly?Gly?Ser?Leu?Ser?Gly?Glu?His?Gly?Asp?Gly?Arg?Ala

455 460 465

cgc?tca?tcc?ttc?ctt?gac?cgc?atg?tat?tca?gca?gaa?atg?cgt?gca?ctc 1555

Arg?Ser?Ser?Phe?Leu?Asp?Arg?Met?Tyr?Ser?Ala?Glu?Met?Arg?Ala?Leu

470 475 480 485

ttc?gaa?gaa?ttc?aag?ctg?att?ttc?gat?ccc?cag?cgc?atc?ttc?aat?ccg 1603

Phe?Glu?Glu?Phe?Lys?Leu?Ile?Phe?Asp?Pro?Gln?Arg?Ile?Phe?Asn?Pro

490 495 500

gga?gtg?ttg?gtc?tgg?gca?gat?cct?gtc?atg?caa?gga?ctt?cgc?atg?gac 1651

Gly?Val?Leu?Val?Trp?Ala?Asp?Pro?Val?Met?Gln?Gly?Leu?Arg?Met?Asp

505 510 515

ccg?ggc?cag?cgc?gcc?ctc?gac?atc?acg?ccc?gta?cac?aaa?ttc?tct?aaa 1699

Pro?Gly?Gln?Arg?Ala?Leu?Asp?Ile?Thr?Pro?Val?His?Lys?Phe?Ser?Lys

520 525 530

gac?aaa?ggt?tcc?atg?atc?aac?gcg?gtg?aat?cgc?tgc?gtg?ggt?gta?tcc 1747

Asp?Lys?Gly?Ser?Met?Ile?Asn?Ala?Val?Asn?Arg?Cys?Val?Gly?Val?Ser

535 540 545

gca?tgc?cgc?tca?gaa?tcc?gac?gcg?atg?tgc?ccg?tcc?ttc?caa?atc?acc 1795

Ala?Cys?Arg?Ser?Glu?Ser?Asp?Ala?Met?Cys?Pro?Ser?Phe?Gln?Ile?Thr

550 555 560 565

ggc?gac?gaa?gta?cat?tcc?acc?aga?ggc?cgc?gcc?cgc?ttg?ctc?tct?gag 1843

Gly?Asp?Glu?Val?His?Ser?Thr?Arg?Gly?Arg?Ala?Arg?Leu?Leu?Ser?Glu

570 575 580

atg?ttc?cgc?ggt?gaa?tcc?atc?gcc?gac?ggc?tac?cgc?agc?gaa?gaa?gtc 1891

Met?Phe?Arg?Gly?Glu?Ser?Ile?Ala?Asp?Gly?Tyr?Arg?Ser?Glu?Glu?Val

585 590 595

aat?gaa?gcc?ctt?gac?ctg?tgc?ctt?tcc?tgc?aaa?gca?tgc?gca?tcg?gaa 1939

Asn?Glu?Ala?Leu?Asp?Leu?Cys?Leu?Ser?Cys?Lys?Ala?Cys?Ala?Ser?Glu

600 605 610

tgt?cca?gtc?aac?gtc?gac?atg?tcc?acc?tac?aaa?gcc?gaa?ttc?ctg?gac 1987

Cys?Pro?Val?Asn?Val?Asp?Met?Ser?Thr?Tyr?Lys?Ala?Glu?Phe?Leu?Asp

615 620 625

aaa?cac?tac?gcc?ggc?cga?ctt?cgc?ccc?atg?gcc?cat?tac?gtc?atg?ggc 2035

Lys?His?Tyr?Ala?Gly?Arg?Leu?Arg?Pro?Met?Ala?His?Tyr?Val?Met?Gly

630 635 640 645

tgg?ctg?ccg?ctt?ctg?gga?cac?gtt?gcc?cat?aaa?ata?ccg?ctt?ctt?cct 2083

Trp?Leu?Pro?Leu?Leu?Gly?His?Val?Ala?His?Lys?Ile?Pro?Leu?Leu?Pro

650 655 660

acg?ctt?atc?gac?gcc?acc?atg?cag?tca?gca?ctc?acc?gcc?cca?gtg?gtg 2131

Thr?Leu?Ile?Asp?Ala?Thr?Met?Gln?Ser?Ala?Leu?Thr?Ala?Pro?Val?Val

665 670 675

cgc?aag?gtc?ggc?ggg?ctc?gct?gat?cgc?ccg?ttg?att?tcc?ttc?gcc?cac 2179

Arg?Lys?Val?Gly?Gly?Leu?Ala?Asp?Arg?Pro?Leu?Ile?Ser?Phe?Ala?His

680 685 690

cgc?tcg?ctg?cgc?aag?tac?aag?ccg?aag?aaa?aac?tca?ggt?gaa?acg?gtg 2227

Arg?Ser?Leu?Arg?Lys?Tyr?Lys?Pro?Lys?Lys?Asn?Ser?Gly?Glu?Thr?Val

695 700 705

gtg?ctg?tgg?ccc?gat?tcc?ttc?aac?acc?aac?ctc?gac?acc?gga?cca?gct 2275

Val?Leu?Trp?Pro?Asp?Ser?Phe?Asn?Thr?Asn?Leu?Asp?Thr?Gly?Pro?Ala

710 715 720 725

cac?gca?gcg?atc?aaa?act?ctt?gaa?gcc?ctc?ggt?tac?aac?gtg?gtc?atc 2323

His?Ala?Ala?Ile?Lys?Thr?Leu?Glu?Ala?Leu?Gly?Tyr?Asn?Val?Val?Ile

730 735 740

cca?gat?ggc?ttc?gtc?tgc?tgt?gga?ctc?acc?tgg?cat?tcc?acc?ggc?caa 2371

Pro?Asp?Gly?Phe?Val?Cys?Cys?Gly?Leu?Thr?Trp?His?Ser?Thr?Gly?Gln

745 750 755

ttg?agc?atg?aca?aag?aaa?gtc?cta?gaa?caa?acg?gcg?aaa?gtg?atg?aaa 2419

Leu?Ser?Met?Thr?Lys?Lys?Val?Leu?Glu?Gln?Thr?Ala?Lys?Val?Met?Lys

760 765 770

ccc?tac?ctg?gac?caa?ggt?cta?aca?gtc?gtt?ggt?ttg?gaa?cct?tcg?tgc 2467

Pro?Tyr?Leu?Asp?Gln?Gly?Leu?Thr?Val?Val?Gly?Leu?Glu?Pro?Ser?Cys

775 780 785

acc?gtc?atg?ctt?caa?gat?gag?gca?aca?gaa?ctc?tcc?gat?aac?cct?gat 2515

Thr?Val?Met?Leu?Gln?Asp?Glu?Ala?Thr?Glu?Leu?Ser?Asp?Asn?Pro?Asp

790 795 800 805

ctg?gca?cgc?ctt?gca?gca?ctg?acc?aaa?cca?ttc?gct?gag?gtc?atc?gca 2563

Leu?Ala?Arg?Leu?Ala?Ala?Leu?Thr?Lys?Pro?Phe?Ala?Glu?Val?Ile?Ala

810 815 820

cca?aag?atc?acc?gag?cta?gtc?gag?tct?gga?agc?ctc?cag?cta?aca?gaa 2611

Pro?Lys?Ile?Thr?Glu?Leu?Val?Glu?Ser?Gly?Ser?Leu?Gln?Leu?Thr?Glu

825 830 835

tca?act?gcg?ctt?acc?cag?gtg?cac?tgc?cac?gag?cgt?tcg?cta?ggc?gac 2659

Ser?Thr?Ala?Leu?Thr?Gln?Val?His?Cys?His?Glu?Arg?Ser?Leu?Gly?Asp

840 845 850

cca?caa?caa?tcg?gca?ctc?gtt?ctt?gaa?gct?ttg?ggt?gta?aaa?gat?gaa 2707

Pro?Gln?Gln?Ser?Ala?Leu?Val?Leu?Glu?Ala?Leu?Gly?Val?Lys?Asp?Glu

855 860 865

caa?att?gcc?act?ggt?tgt?tgc?ggg?ctt?gcc?gga?aac?tgg?ggc?ttt?gaa 2755

Gln?Ile?Ala?Thr?Gly?Cys?Cys?Gly?Leu?Ala?Gly?Asn?Trp?Gly?Phe?Glu

870 875 880 885

aaa?gac?cac?gct?gaa?atg?tcc?ttc?gca?ctt?ggt?gaa?cga?gag?ctg?ttc 2803

Lys?Asp?His?Ala?Glu?Met?Ser?Phe?Ala?Leu?Gly?Glu?Arg?Glu?Leu?Phe

890 895 900

ccc?aag?gtc?aga?aaa?gca?gaa?gga?cat?gtg?att?gct?gac?ggt?ttc?tcc 2851

Pro?Lys?Val?Arg?Lys?Ala?Glu?Gly?His?Val?Ile?Ala?Asp?Gly?Phe?Ser

905 910 915

tgc?cgc?acc?cag?atc?gaa?caa?ggc?acc?gga?aaa?caa?gca?acg?cac?ctt 2899

Cys?Arg?Thr?Gln?Ile?Glu?Gln?Gly?Thr?Gly?Lys?Gln?Ala?Thr?His?Leu

920 925 930

gca?gag?gtg?gtc?tta?agc?atc?ttg?gag?caa?aac?aac?atg?gca?caa 2944

Ala?Glu?Val?Val?Leu?Ser?Ile?Leu?Glu?Gln?Asn?Asn?Met?Ala?Gln

935 940 945

taacgatcat?gcaacaggtg?ctc 2967

<210>132

<211>948

<212>PRT

＜213〉Corynebacterium glutamicum

<400>132

Met?Thr?His?Thr?Ile?Lys?Phe?Asn?Arg?Leu?Asp?Pro?Glu?Val?Phe?Ser

1 5 10 15

Gln?His?Ser?Arg?Ala?Lys?Leu?Arg?Thr?Asp?Met?Thr?Thr?Arg?Ala?Ala

20 25 30

Tyr?Ser?Ser?Asp?Ala?Gly?Ile?Phe?Arg?Arg?Val?Pro?Ala?Ala?Val?Ala

35 40 45

Glu?Pro?Glu?Asn?Val?Glu?Gln?Ile?Arg?Asp?Ala?Ile?Ala?Val?Ala?Val

50 55 60

Ala?Arg?Gly?Trp?Ser?Val?Val?Gly?Arg?Gly?Gly?Gly?Ser?Ser?Val?Ala

65 70 75 80

Gly?Asn?Ala?Ile?Gly?Glu?Gly?Leu?Ile?Ile?Asp?Thr?Ser?Arg?Tyr?Phe

85 90 95

Asn?Arg?Ile?Leu?Asp?Ile?Asp?Pro?Val?Ala?Gln?Thr?Ala?Val?Val?Glu

100 105 110

Pro?Gly?Val?Val?Cys?Asp?Ala?Leu?Arg?Asp?Ala?Ala?Ala?Glu?Phe?Gly

115 120 125

Leu?Thr?Tyr?Gly?Pro?Asp?Pro?Ser?Thr?His?Ser?Arg?Cys?Thr?Ile?Gly

130 135 140

Gly?Met?Val?Ala?Asn?Asn?Ala?Cys?Gly?Ser?His?Ser?Val?Ala?Phe?Gly

145 150 155 160

Thr?Ala?Ala?Glu?Asn?Leu?Val?Asp?Val?Thr?Leu?Met?Leu?Ser?Asp?Gly

165 170 175

Arg?Glu?Val?Thr?Val?Thr?Lys?Asp?Gly?Cys?Asp?Asp?Ala?Glu?Ile?Asn

180 185 190

Gln?Lys?Leu?Thr?Asp?Leu?Ala?Ser?Lys?Asn?Gln?Asp?Leu?Ile?Ser?Lys

195 200 205

Glu?Leu?Gly?Arg?Phe?Pro?Arg?Gln?Val?Ser?Gly?Tyr?Gly?Leu?His?Tyr

210 215 220

Leu?Ala?His?Asp?Met?Ala?Lys?Ala?Met?Ala?Gly?Thr?Glu?Gly?Thr?Ile

225 230 235 240

Gly?Ile?Ile?Thr?Arg?Leu?Thr?Val?Lys?Leu?Val?Pro?Thr?Pro?Lys?Val

245 250 255

Lys?Ala?Leu?Ala?Val?Leu?Ala?Phe?Asp?Thr?Val?Phe?Asp?Ala?Ala?Arg

260 265 270

Ala?Ala?Ala?Lys?Leu?Arg?Leu?Pro?Gly?Val?Ala?Thr?Ile?Glu?Gly?Met

275 280 285

Gly?Gly?Asp?Leu?Leu?Ala?Ala?Leu?Arg?Ser?Lys?Gln?Gly?Gln?Ser?Glu

290 295 300

Ala?Gly?Gln?Asn?Leu?Pro?Gly?Asn?Arg?Ile?Gly?Ile?Glu?Ala?Gly?Gly

305 310 315 320

Trp?Leu?Tyr?Cys?Glu?Thr?Gly?Ser?Asp?Thr?Leu?Gln?Ala?Ala?Val?Gln

325 330 335

Ala?Ala?Glu?Glu?Val?Ala?Thr?Ala?Val?Asp?Thr?Ile?Asp?Tyr?Val?Val

340 345 350

Val?Ser?Glu?Pro?Ser?Glu?Met?Arg?Glu?Leu?Trp?Arg?Ile?Arg?Glu?Ser

355 360 365

Ser?Ala?Gly?Ile?Val?Thr?Arg?Leu?Ala?Asp?Gly?Gly?Glu?Ala?Trp?Pro

370 375 380

Asn?Trp?Glu?Asp?Ser?Ala?Val?Pro?Pro?Glu?Asn?Leu?Ala?Asp?Tyr?Leu

385 390 395 400

Arg?Asp?Leu?Tyr?Ala?Leu?Met?Asp?Lys?Phe?Asp?Tyr?Gln?Gly?Ile?Pro

405 410 415

Phe?Gly?His?Phe?Gly?Glu?Gly?Cys?Val?His?Val?Arg?Ile?Ser?Phe?Asp

420 425 430

Phe?Ser?Thr?Lys?Glu?Gly?Leu?Lys?Lys?Phe?Glu?Ala?Phe?Met?Asn?Glu

435 440 445

Ala?Ser?Thr?Leu?Val?Ala?Ser?Tyr?Gly?Gly?Ser?Leu?Ser?Gly?Glu?His

450 455 460

Gly?Asp?Gly?Arg?Ala?Arg?Ser?Ser?Phe?Leu?Asp?Arg?Met?Tyr?Ser?Ala

465 470 475 480

Glu?Met?Arg?Ala?Leu?Phe?Glu?Glu?Phe?Lys?Leu?Ile?Phe?Asp?Pro?Gln

485 490 495

Arg?Ile?Phe?Asn?Pro?Gly?Val?Leu?Val?Trp?Ala?Asp?Pro?Val?Met?Gln

500 505 510

Gly?Leu?Arg?Met?Asp?Pro?Gly?Gln?Arg?Ala?Leu?Asp?Ile?Thr?Pro?Val

515 520 525

His?Lys?Phe?Ser?Lys?Asp?Lys?Gly?Ser?Met?Ile?Asn?Ala?Val?Asn?Arg

530 535 540

Cys?Val?Gly?Val?Ser?Ala?Cys?Arg?Ser?Glu?Ser?Asp?Ala?Met?Cys?Pro

545 550 555 560

Ser?Phe?Gln?Ile?Thr?Gly?Asp?Glu?Val?His?Ser?Thr?Arg?Gly?Arg?Ala

565 570 575

Arg?Leu?Leu?Ser?Glu?Met?Phe?Arg?Gly?Glu?Ser?Ile?Ala?Asp?Gly?Tyr

580 585 590

Arg?Ser?Glu?Glu?Val?Asn?Glu?Ala?Leu?Asp?Leu?Cys?Leu?Ser?Cys?Lys

595 600 605

Ala?Cys?Ala?Ser?Glu?Cys?Pro?Val?Asn?Val?Asp?Met?Ser?Thr?Tyr?Lys

610 615 620

Ala?Glu?Phe?Leu?Asp?Lys?His?Tyr?Ala?Gly?Arg?Leu?Arg?Pro?Met?Ala

625 630 635 640

His?Tyr?Val?Met?Gly?Trp?Leu?Pro?Leu?Leu?Gly?His?Val?Ala?His?Lys

645 650 655

Ile?Pro?Leu?Leu?Pro?Thr?Leu?Ile?Asp?Ala?Thr?Met?Gln?Ser?Ala?Leu

660 665 670

Thr?Ala?Pro?Val?Val?Arg?Lys?Val?Gly?Gly?Leu?Ala?Asp?Arg?Pro?Leu

675 680 685

Ile?Ser?Phe?Ala?His?Arg?Ser?Leu?Arg?Lys?Tyr?Lys?Pro?Lys?Lys?Asn

690 695 700

Ser?Gly?Glu?Thr?Val?Val?Leu?Trp?Pro?Asp?Ser?Phe?Asn?Thr?Asn?Leu

705 710 715 720

Asp?Thr?Gly?Pro?Ala?His?Ala?Ala?Ile?Lys?Thr?Leu?Glu?Ala?Leu?Gly

725 730 735

Tyr?Asn?Val?Val?Ile?Pro?Asp?Gly?Phe?Val?Cys?Cys?Gly?Leu?Thr?Trp

740 745 750

His?Ser?Thr?Gly?Gln?Leu?Ser?Met?Thr?Lys?Lys?Val?Leu?Glu?Gln?Thr

755 760 765

Ala?Lys?Val?Met?Lys?Pro?Tyr?Leu?Asp?Gln?Gly?Leu?Thr?Val?Val?Gly

770 775 780

Leu?Glu?Pro?Ser?Cys?Thr?Val?Met?Leu?Gln?Asp?Glu?Ala?Thr?Glu?Leu

785 790 795 800

Ser?Asp?Asn?Pro?Asp?Leu?Ala?Arg?Leu?Ala?Ala?Leu?Thr?Lys?Pro?Phe

805 810 815

Ala?Glu?Val?Ile?Ala?Pro?Lys?Ile?Thr?Glu?Leu?Val?Glu?Ser?Gly?Ser

820 825 830

Leu?Gln?Leu?Thr?Glu?Ser?Thr?Ala?Leu?Thr?Gln?Val?His?Cys?His?Glu

835 840 845

Arg?Ser?Leu?Gly?Asp?Pro?Gln?Gln?Ser?Ala?Leu?Val?Leu?Glu?Ala?Leu

850 855 860

Gly?Val?Lys?Asp?Glu?Gln?Ile?Ala?Thr?Gly?Cys?Cys?Gly?Leu?Ala?Gly

865 870 875 880

Asn?Trp?Gly?Phe?Glu?Lys?Asp?His?Ala?Glu?Met?Ser?Phe?Ala?Leu?Gly

885 890 895

Glu?Arg?Glu?Leu?Phe?Pro?Lys?Val?Arg?Lys?Ala?Glu?Gly?His?Val?Ile

900 905 910

Ala?Asp?Gly?Phe?Ser?Cys?Arg?Thr?Gln?Ile?Glu?Gln?Gly?Thr?Gly?Lys

915 920 925

Gln?Ala?Thr?His?Leu?Ala?Glu?Val?Val?Leu?Ser?Ile?Leu?Glu?Gln?Asn

930 935 940

Asn?Met?Ala?Gln

945

<210>133

<211>2858

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(2835)

<223>FRXA00296

<400>133

acc?atc?aaa?ttc?aac?aga?ctc?gac?cca?gaa?gta?ttt?agc?cag?cat?tct 48

Thr?Ile?Lys?Phe?Asn?Arg?Leu?Asp?Pro?Glu?Val?Phe?Ser?Gln?His?Ser

1 5 10 15

cgc?gcg?aag?ctg?cgc?acg?gat?atg?aca?acc?cgt?gca?gca?tat?tct?tct 96

Arg?Ala?Lys?Leu?Arg?Thr?Asp?Met?Thr?Thr?Arg?Ala?Ala?Tyr?Ser?Ser

20 25 30

gat?gca?gga?att?ttt?aga?cgc?gtc?cct?gca?gct?gta?gct?gaa?cca?gaa 144

Asp?Ala?Gly?Ile?Phe?Arg?Arg?Val?Pro?Ala?Ala?Val?Ala?Glu?Pro?Glu

35 40 45

aat?gtg?gaa?caa?att?cgt?gat?gcc?att?gct?gtt?gcg?gtg?gca?cga?ggg 192

Asn?Val?Glu?Gln?Ile?Arg?Asp?Ala?Ile?Ala?Val?Ala?Val?Ala?Arg?Gly

50 55 60

tgg?tct?gtt?gtt?ggg?cgc?ggt?gga?gga?agc?tcg?gtt?gct?gga?aat?gcg 240

Trp?Ser?Val?Val?Gly?Arg?Gly?Gly?Gly?Ser?Ser?Val?Ala?Gly?Asn?Ala

65 70 75 80

atc?ggt?gaa?ggt?ttg?atc?atc?gat?acg?tca?cgc?tat?ttc?aac?cgc?att 288

Ile?Gly?Glu?Gly?Leu?Ile?Ile?Asp?Thr?Ser?Arg?Tyr?Phe?Asn?Arg?Ile

85 90 95

tta?gat?att?gat?cca?gtt?gca?caa?act?gca?gtt?gtg?gaa?ccc?ggt?gtg 336

Leu?Asp?Ile?Asp?Pro?Val?Ala?Gln?Thr?Ala?Val?Val?Glu?Pro?Gly?Val

100 105 110

gtg?tgt?gat?gcc?ttg?cgc?gat?gca?gcc?gca?gaa?ttc?gga?tta?act?tac 384

Val?Cys?Asp?Ala?Leu?Arg?Asp?Ala?Ala?Ala?Glu?Phe?Gly?Leu?Thr?Tyr

115 120 125

ggc?ccg?gat?cct?tcc?acg?cat?tcc?cgg?tgc?acg?atc?ggt?ggc?atg?gtt 432

Gly?Pro?Asp?Pro?Ser?Thr?His?Ser?Arg?Cys?Thr?Ile?Gly?Gly?Met?Val

130 135 140

gcc?aac?aat?gcg?tgt?ggt?tca?cac?tcg?gtt?gca?ttc?ggt?aca?gct?gcg 480

Ala?Asn?Asn?Ala?Cys?Gly?Ser?His?Ser?Val?Ala?Phe?Gly?Thr?Ala?Ala

145 150 155 160

gaa?aat?ctc?gtg?gat?gtc?acg?ctc?atg?ctc?agc?gat?ggc?cga?gaa?gtc 528

Glu?Asn?Leu?Val?Asp?Val?Thr?Leu?Met?Leu?Ser?Asp?Gly?Arg?Glu?Val

165 170 175

act?gtg?aca?aaa?gat?ggc?tgc?gat?gat?gct?gag?atc?aat?cag?aag?ctc 576

Thr?Val?Thr?Lys?Asp?Gly?Cys?Asp?Asp?Ala?Glu?Ile?Asn?Gln?Lys?Leu

180 185 190

acc?gac?tta?gcg?tcc?aag?aat?cag?gac?ctt?att?agt?aaa?gaa?ctg?ggt 624

Thr?Asp?Leu?Ala?Ser?Lys?Asn?Gln?Asp?Leu?Ile?Ser?Lys?Glu?Leu?Gly

195 200 205

cgt?ttc?cct?cgc?caa?gtg?tcg?ggc?tac?ggt?ttg?cat?tat?ctt?gcc?cac 672

Arg?Phe?Pro?Arg?Gln?Val?Ser?Gly?Tyr?Gly?Leu?His?Tyr?Leu?Ala?His

210 215 220

gac?atg?gcc?aaa?gca?atg?gcg?ggc?acc?gag?gga?acc?att?gga?atc?att 720

Asp?Met?Ala?Lys?Ala?Met?Ala?Gly?Thr?Glu?Gly?Thr?Ile?Gly?Ile?Ile

225 230 235 240

act?cgg?ttg?acg?gtg?aag?ttg?gtt?cca?aca?ccc?aaa?gtg?aaa?gcg?ctt 768

Thr?Arg?Leu?Thr?Val?Lys?Leu?Val?Pro?Thr?Pro?Lys?Val?Lys?Ala?Leu

245 250 255

gct?gtc?ctg?gct?ttc?gac?acg?gtt?ttt?gac?gcc?gcc?cga?gca?gcc?gcc 816

Ala?Val?Leu?Ala?Phe?Asp?Thr?Val?Phe?Asp?Ala?Ala?Arg?Ala?Ala?Ala

260 265 270

aaa?ttg?cga?ctg?cct?ggg?gta?gca?acc?att?gaa?ggc?atg?ggc?gga?gat 864

Lys?Leu?Arg?Leu?Pro?Gly?Val?Ala?Thr?Ile?Glu?Gly?Met?Gly?Gly?Asp

275 280 285

ctc?ctc?gct?gcg?ctg?cgc?agt?aaa?cag?gga?caa?tca?gaa?gct?ggg?cag 912

Leu?Leu?Ala?Ala?Leu?Arg?Ser?Lys?Gln?Gly?Gln?Ser?Glu?Ala?Gly?Gln

290 295 300

aat?ctt?cca?gga?aac?cgc?atc?ggc?att?gaa?gcc?ggc?gga?tgg?ttg?tac 960

Asn?Leu?Pro?Gly?Asn?Arg?Ile?Gly?Ile?Glu?Ala?Gly?Gly?Trp?Leu?Tyr

305 310 315 320

tgc?gag?aca?gga?agt?gac?acc?ctg?cag?gcc?gcg?gta?caa?gcc?gcc?gag 1008

Cys?Glu?Thr?Gly?Ser?Asp?Thr?Leu?Gln?Ala?Ala?Val?Gln?Ala?Ala?Glu

325 330 335

gaa?gtc?gca?acc?gcc?gtt?gac?acc?att?gat?tac?gtg?gtc?gtg?tct?gag 1056

Glu?Val?Ala?Thr?Ala?Val?Asp?Thr?Ile?Asp?Tyr?Val?Val?Val?Ser?Glu

340 345 350

cct?tct?gaa?atg?cgg?gaa?ttg?tgg?cgc?atc?cgt?gaa?tcc?tcg?gcg?ggc 1104

Pro?Ser?Glu?Met?Arg?Glu?Leu?Trp?Arg?Ile?Arg?Glu?Ser?Ser?Ala?Gly

355 360 365

att?gtc?acg?cgc?tta?gct?gat?ggt?ggg?gaa?gcg?tgg?ccg?aat?tgg?gaa 1152

Ile?Val?Thr?Arg?Leu?Ala?Asp?Gly?Gly?Glu?Ala?Trp?Pro?Asn?Trp?Glu

370 375 380

gac?tcg?gcg?gtg?cct?cca?gag?aat?tta?gct?gat?tat?ctc?cgc?gat?ctt 1200

Asp?Ser?Ala?Val?Pro?Pro?Glu?Asn?Leu?Ala?Asp?Tyr?Leu?Arg?Asp?Leu

385 390 395 400

tat?gcg?ctg?atg?gat?aag?ttc?gat?tac?cag?ggt?att?cca?ttt?gga?cac 1248

Tyr?Ala?Leu?Met?Asp?Lys?Phe?Asp?Tyr?Gln?Gly?Ile?Pro?Phe?Gly?His

405 410 415

ttt?gga?gaa?ggc?tgc?gtc?cac?gtt?cgc?atc?agt?ttt?gat?ttc?tct?acc 1296

Phe?Gly?Glu?Gly?Cys?Val?His?Val?Arg?Ile?Ser?Phe?Asp?Phe?Ser?Thr

420 425 430

aag?gaa?ggc?ctg?aag?aaa?ttc?gag?gcg?ttc?atg?aat?gaa?gcc?tcc?acc 1344

Lys?Glu?Gly?Leu?Lys?Lys?Phe?Glu?Ala?Phe?Met?Asn?Glu?Ala?Ser?Thr

435 440 445

ttg?gtg?gcg?tct?tat?ggt?ggc?agc?ctc?tcg?ggc?gag?cat?gga?gac?ggt 1392

Leu?Val?Ala?Ser?Tyr?Gly?Gly?Ser?Leu?Ser?Gly?Glu?His?Gly?Asp?Gly

450 455 460

cgc?gcc?cgc?tca?tcc?ttc?ctt?gac?cgc?atg?tat?tca?gca?gaa?atg?cgt 1440

Arg?Ala?Arg?Ser?Ser?Phe?Leu?Asp?Arg?Met?Tyr?Ser?Ala?Glu?Met?Arg

465 470 475 480

gca?ctc?ttc?gaa?gaa?ttc?aag?ctg?att?ttc?gat?ccc?cag?cgc?atc?ttc 1488

Ala?Leu?Phe?Glu?Glu?Phe?Lys?Leu?Ile?Phe?Asp?Pro?Gln?Arg?Ile?Phe

485 490 495

aat?ccg?gga?gtg?ttg?gtc?tgg?gca?gat?cct?gtc?atg?caa?gga?ctt?cgc 1536

Asn?Pro?Gly?Val?Leu?Val?Trp?Ala?Asp?Pro?Val?Met?Gln?Gly?Leu?Arg

500 505 510

atg?gac?ccg?ggc?cag?cgc?gcc?ctc?gac?atc?acg?ccc?gta?cac?aaa?ttc 1584

Met?Asp?Pro?Gly?Gln?Arg?Ala?Leu?Asp?Ile?Thr?Pro?Val?His?Lys?Phe

515 520 525

tct?aaa?gac?aaa?ggt?tcc?atg?atc?aac?gcg?gtg?aat?cgc?tgc?gtg?ggt 1632

Ser?Lys?Asp?Lys?Gly?Ser?Met?Ile?Asn?Ala?Val?Asn?Arg?Cys?Val?Gly

530 535 540

gta?tcc?gca?tgc?cgc?tca?gaa?tcc?gac?gcg?atg?tgc?ccg?tcc?ttc?caa 1680

Val?Ser?Ala?Cys?Arg?Ser?Glu?Ser?Asp?Ala?Met?Cys?Pro?Ser?Phe?Gln

545 550 555 560

atc?acc?ggc?gac?gaa?gta?cat?tcc?acc?aga?ggc?cgc?gcc?cgc?ttg?ctc 1728

Ile?Thr?Gly?Asp?Glu?Val?His?Ser?Thr?Arg?Gly?Arg?Ala?Arg?Leu?Leu

565 570 575

tct?gag?atg?ttc?cgc?ggt?gaa?tcc?atc?gcc?gac?ggc?tac?cgc?agc?gaa 1776

Ser?Glu?Met?Phe?Arg?Gly?Glu?Ser?Ile?Ala?Asp?Gly?Tyr?Arg?Ser?Glu

580 585 590

gaa?gtc?aat?gaa?gcc?ctt?gac?ctg?tgc?ctt?tcc?tgc?aaa?gca?tgc?gca 1824

Glu?Val?Asn?Glu?Ala?Leu?Asp?Leu?Cys?Leu?Ser?Cys?Lys?Ala?Cys?Ala

595 600 605

tcg?gaa?tgt?cca?gtc?aac?gtc?gac?atg?tcc?acc?tac?aaa?gcc?gaa?ttc 1872

Ser?Glu?Cys?Pro?Val?Asn?Val?Asp?Met?Ser?Thr?Tyr?Lys?Ala?Glu?Phe

610 615 620

ctg?gac?aaa?cac?tac?gcc?ggc?cga?ctt?cgc?ccc?atg?gcc?cat?tac?gtc 1920

Leu?Asp?Lys?His?Tyr?Ala?Gly?Arg?Leu?Arg?Pro?Met?Ala?His?Tyr?Val

625 630 635 640

atg?ggc?tgg?ctg?ccg?ctt?ctg?gga?cac?gtt?gcc?cat?aaa?ata?ccg?ctt 1968

Met?Gly?Trp?Leu?Pro?Leu?Leu?Gly?His?Val?Ala?His?Lys?Ile?Pro?Leu

645 650 655

ctt?cct?acg?ctt?atc?gac?gcc?acc?atg?cag?tca?gca?ctc?acc?gcc?cca 2016

Leu?Pro?Thr?Leu?Ile?Asp?Ala?Thr?Met?Gln?Ser?Ala?Leu?Thr?Ala?Pro

660 665 670

gtg?gtg?cgc?aag?gtc?ggc?ggg?ctc?gct?gat?cgc?ccg?ttg?att?tcc?ttc 2064

Val?Val?Arg?Lys?Val?Gly?Gly?Leu?Ala?Asp?Arg?Pro?Leu?Ile?Ser?Phe

675 680 685

gcc?cac?cgc?tcg?ctg?cgc?aag?tac?aag?ccg?aag?aaa?aac?tca?ggt?gaa 2112

Ala?His?Arg?Ser?Leu?Arg?Lys?Tyr?Lys?Pro?Lys?Lys?Asn?Ser?Gly?Glu

690 695 700

acg?gtg?gtg?ctg?tgg?ccc?gat?tcc?ttc?aac?acc?aac?ctc?gac?acc?gga 2160

Thr?Val?Val?Leu?Trp?Pro?Asp?Ser?Phe?Asn?Thr?Asn?Leu?Asp?Thr?Gly

705 710 715 720

cca?gct?cac?gca?gcg?atc?aaa?act?ctt?gaa?gcc?ctc?ggt?tac?aac?gtg 2208

Pro?Ala?His?Ala?Ala?Ile?Lys?Thr?Leu?Glu?Ala?Leu?Gly?Tyr?Asn?Val

725 730 735

gtc?atc?cca?gat?ggc?ttc?gtc?tgc?tgt?gga?ctc?acc?tgg?cat?tcc?acc 2256

Val?Ile?Pro?Asp?Gly?Phe?Val?Cys?Cys?Gly?Leu?Thr?Trp?His?Ser?Thr

740 745 750

ggc?caa?ttg?agc?atg?aca?aag?aaa?gtc?cta?gaa?caa?acg?gcg?aaa?gtg 2304

Gly?Gln?Leu?Ser?Met?Thr?Lys?Lys?Val?Leu?Glu?Gln?Thr?Ala?Lys?Val

755 760 765

atg?aaa?ccc?tac?ctg?gac?caa?ggt?cta?aca?gtc?gtt?ggt?ttg?gaa?cct 2352

Met?Lys?Pro?Tyr?Leu?Asp?Gln?Gly?Leu?Thr?Val?Val?Gly?Leu?Glu?Pro

770 775 780

tcg?tgc?acc?gtc?atg?ctt?caa?gat?gag?gca?aca?gaa?ctc?tcc?gat?aac 2400

Ser?Cys?Thr?Val?Met?Leu?Gln?Asp?Glu?Ala?Thr?Glu?Leu?Ser?Asp?Asn

785 790 795 800

cct?gat?ctg?gca?cgc?ctt?gca?gca?ctg?acc?aaa?cca?ttc?gct?gag?gtc 2448

Pro?Asp?Leu?Ala?Arg?Leu?Ala?Ala?Leu?Thr?Lys?Pro?Phe?Ala?Glu?Val

805 810 815

atc?gca?cca?aag?atc?acc?gag?cta?gtc?gag?tct?gga?agc?ctc?cag?cta 2496

Ile?Ala?Pro?Lys?Ile?Thr?Glu?Leu?ValGlu?Ser?Gly?Ser?Leu?Gln?Leu

820 825 830

aca?gaa?tca?act?gcg?ctt?acc?cag?gtg?cac?tgc?cac?gag?cgt?tcg?cta 2544

Thr?Glu?Ser?Thr?Ala?Leu?Thr?Gln?Val?His?Cys?His?Glu?Arg?Ser?Leu

835 840 845

ggc?gac?cca?caa?caa?tcg?gca?ctc?gtt?ctt?gaa?gct?ttg?ggt?gta?aaa 2592

Gly?Asp?Pro?Gln?Gln?Ser?Ala?Leu?Val?Leu?Glu?Ala?Leu?Gly?ValLys

850 855 860

gat?gaa?caa?att?gcc?act?ggt?tgt?tgc?ggg?ctt?gcc?gga?aac?tgg?ggc 2640

Asp?Glu?Gln?Ile?Ala?Thr?Gly?Cys?Cys?Gly?Leu?Ala?Gly?Asn?Trp?Gly

865 870 875 880

ttt?gaa?aaa?gac?cac?gct?gaa?atg?tcc?ttc?gca?ctt?ggt?gaa?cga?gag 2688

Phe?Glu?Lys?Asp?His?Ala?Glu?Met?Ser?Phe?Ala?Leu?Gly?Glu?Arg?Glu

885 890 895

ctg?ttc?ccc?aag?gtc?aga?aaa?gca?gaa?gga?cat?gtg?att?gct?gac?ggt 2736

Leu?Phe?Pro?Lys?Val?Arg?Lys?Ala?Glu?Gly?His?Val?Ile?Ala?Asp?Gly

900 905 910

ttc?tcc?tgc?cgc?acc?cag?atc?gaa?caa?ggc?acc?gga?aaa?caa?gca?acg 2784

Phe?Ser?Cys?Arg?Thr?Gln?Ile?Glu?Gln?Gly?Thr?Gly?Lys?Gln?Ala?Thr

915 920 925

cac?ctt?gca?gag?gtg?gtc?tta?agc?atc?ttg?gag?caa?aac?aac?atg?gca 2832

His?Leu?Ala?Glu?Val?Val?Leu?Ser?Ile?Leu?Glu?Gln?Asn?Asn?Met?Ala

930 935 940

caa?taacgatcat?gcaacaggtg?ctc 2858

Gln

945

<210>134

<211>945

<212>PRT

＜213〉Corynebacterium glutamicum

<400>134

Thr?Ile?Lys?Phe?Asn?Arg?Leu?Asp?Pro?Glu?Val?Phe?Ser?Gln?His?Ser

1 5 10 15

Arg?Ala?Lys?Leu?Arg?Thr?Asp?Met?Thr?Thr?Arg?Ala?Ala?Tyr?Ser?Ser

20 25 30

Asp?Ala?Gly?Ile?Phe?Arg?Arg?Val?Pro?Ala?Ala?Val?Ala?Glu?Pro?Glu

35 40 45

Asn?Val?Glu?Gln?Ile?Arg?Asp?Ala?Ile?Ala?Val?Ala?Val?Ala?Arg?Gly

50 55 60

Trp?Ser?Val?Val?Gly?Arg?Gly?Gly?Gly?Ser?Ser?Val?Ala?Gly?Asn?Ala

65 70 75 80

Ile?Gly?Glu?Gly?Leu?Ile?Ile?Asp?Thr?Ser?Arg?Tyr?Phe?Asn?Arg?Ile

85 90 95

Leu?Asp?Ile?Asp?Pro?Val?Ala?Gln?Thr?Ala?Val?Val?Glu?Pro?Gly?Val

100 105 110

Val?Cys?Asp?Ala?Leu?Arg?Asp?Ala?Ala?Ala?Glu?Phe?Gly?Leu?Thr?Tyr

115 120 125

Gly?Pro?Asp?Pro?Ser?Thr?His?Ser?Arg?Cys?Thr?Ile?Gly?Gly?Met?Val

130 135 140

Ala?Asn?Asn?Ala?Cys?Gly?Ser?His?Ser?Val?Ala?Phe?Gly?Thr?Ala?Ala

145 150 155 160

Glu?Asn?Leu?Val?Asp?Val?Thr?Leu?Met?Leu?Ser?Asp?Gly?Arg?Glu?Val

165 170 175

Thr?Val?Thr?Lys?Asp?Gly?Cys?Asp?Asp?Ala?Glu?Ile?Asn?Gln?Lys?Leu

180 185 190

Thr?Asp?Leu?Ala?Ser?Lys?Asn?Gln?Asp?Leu?Ile?Ser?Lys?Glu?Leu?Gly

195 200 205

Arg?Phe?Pro?Arg?Gln?Val?Ser?Gly?Tyr?Gly?Leu?His?Tyr?Leu?Ala?His

210 215 220

Asp?Met?Ala?Lys?Ala?Met?Ala?Gly?Thr?Glu?Gly?Thr?Ile?Gly?Ile?Ile

225 230 235 240

Thr?Arg?Leu?Thr?Val?Lys?Leu?Val?Pro?Thr?Pro?Lys?Val?Lys?Ala?Leu

245 250 255

Ala?Val?Leu?Ala?Phe?Asp?Thr?Val?Phe?Asp?Ala?Ala?Arg?Ala?Ala?Ala

260 265 270

Lys?Leu?Arg?Leu?Pro?Gly?Val?Ala?Thr?Ile?Glu?Gly?Met?Gly?Gly?Asp

275 280 285

Leu?Leu?Ala?Ala?Leu?Arg?Ser?Lys?Gln?Gly?Gln?Ser?Glu?AlaGly?Gln

290 295 300

Asn?Leu?Pro?Gly?Asn?Arg?Ile?Gly?Ile?Glu?Ala?Gly?Gly?Trp?Leu?Tyr

305 310 315 320

Cys?Glu?Thr?Gly?Ser?Asp?Thr?Leu?Gln?Ala?Ala?Val?Gln?Ala?Ala?Glu

325 330 335

Glu?Val?Ala?Thr?Ala?Val?Asp?Thr?Ile?Asp?Tyr?Val?Val?Val?Ser?Glu

340 345 350

Pro?Ser?Glu?Met?Arg?Glu?Leu?Trp?Arg?Ile?Arg?Glu?Ser?Ser?Ala?Gly

355 360 365

Ile?Val?Thr?Arg?Leu?Ala?Asp?Gly?Gly?Glu?Ala?Trp?Pro?Asn?Trp?Glu

370 375 380

Asp?Ser?Ala?Val?Pro?Pro?Glu?Asn?Leu?Ala?Asp?Tyr?Leu?Arg?Asp?Leu

385 390 395 400

Tyr?Ala?Leu?Met?Asp?Lys?Phe?Asp?Tyr?Gln?Gly?Ile?Pro?Phe?Gly?His

405 410 415

Phe?Gly?Glu?Gly?Cys?Val?His?Val?Arg?Ile?Ser?Phe?Asp?Phe?Ser?Thr

420 425 430

Lys?Glu?Gly?Leu?Lys?Lys?Phe?Glu?Ala?Phe?Met?Asn?Glu?Ala?Ser?Thr

435 440 445

Leu?Val?Ala?Ser?Tyr?Gly?Gly?Ser?Leu?Ser?Gly?Glu?His?Gly?Asp?Gly

450 455 460

Arg?Ala?Arg?Ser?Ser?Phe?Leu?Asp?Arg?Met?Tyr?Ser?Ala?Glu?Met?Arg

465 470 475 480

Ala?Leu?Phe?Glu?Glu?Phe?Lys?Leu?Ile?Phe?Asp?Pro?Gln?Arg?Ile?Phe

485 490 495

Asn?Pro?Gly?Val?Leu?Val?Trp?Ala?Asp?Pro?Val?Met?Gln?Gly?Leu?Arg

500 505 510

Met?Asp?Pro?Gly?Gln?Arg?Ala?Leu?Asp?Ile?Thr?Pro?Val?His?Lys?Phe

515 520 525

Ser?Lys?Asp?Lys?Gly?Ser?Met?Ile?Asn?Ala?Val?Asn?Arg?Cys?Val?Gly

530 535 540

Val?Ser?Ala?Cys?Arg?Ser?Glu?Ser?Asp?Ala?Met?Cys?Pro?Ser?Phe?Gln

545 550 555 560

Ile?Thr?Gly?Asp?Glu?Val?His?Ser?Thr?Arg?Gly?Arg?Ala?Arg?Leu?Leu

565 570 575

Ser?Glu?Met?Phe?Arg?Gly?Glu?Ser?Ile?Ala?Asp?Gly?Tyr?Arg?Ser?Glu

580 585 590

Glu?Val?Asn?Glu?Ala?Leu?Asp?Leu?Cys?Leu?Ser?Cys?Lys?Ala?Cys?Ala

595 600 605

Ser?Glu?Cys?Pro?Val?Asn?Val?Asp?Met?Ser?Thr?Tyr?Lys?Ala?Glu?Phe

610 615 620

Leu?Asp?Lys?His?Tyr?Ala?Gly?Arg?Leu?Arg?Pro?Met?Ala?His?Tyr?Val

625 630 635 640

Met?Gly?Trp?Leu?Pro?Leu?Leu?Gly?His?Val?Ala?His?Lys?Ile?Pro?Leu

645 650 655

Leu?Pro?Thr?Leu?Ile?Asp?Ala?Thr?Met?Gln?Ser?Ala?Leu?Thr?Ala?Pro

660 665 670

Val?Val?Arg?Lys?Val?Gly?Gly?Leu?Ala?Asp?Arg?Pro?Leu?Ile?Ser?Phe

675 680 685

Ala?His?Arg?Ser?Leu?Arg?Lys?Tyr?Lys?Pro?Lys?Lys?Asn?Ser?Gly?Glu

690 695 700

Thr?Val?Val?Leu?Trp?Pro?Asp?Ser?Phe?Asn?Thr?Asn?Leu?Asp?Thr?Gly

705 710 715 720

Pro?Ala?His?Ala?Ala?Ile?Lys?Thr?Leu?Glu?Ala?Leu?Gly?Tyr?Asn?Val

725 730 735

Val?Ile?Pro?Asp?Gly?Phe?Val?Cys?Cys?Gly?Leu?Thr?Trp?His?Ser?Thr

740 745 750

Gly?Gln?Leu?Ser?Met?Thr?Lys?Lys?Val?Leu?Glu?Gln?Thr?Ala?Lys?Val

755 760 765

Met?Lys?Pro?Tyr?Leu?Asp?Gln?Gly?Leu?Thr?Val?Val?Gly?Leu?Glu?Pro

770 775 780

Ser?Cys?Thr?Val?Met?Leu?Gln?Asp?Glu?Ala?Thr?Glu?Leu?Ser?Asp?Asn

785 790 795 800

Pro?Asp?Leu?Ala?Arg?Leu?Ala?Ala?Leu?Thr?Lys?Pro?Phe?Ala?Glu?Val

805 810 815

Ile?Ala?Pro?Lys?Ile?Thr?Glu?Leu?Val?Glu?Ser?Gly?Ser?Leu?Gln?Leu

820 825 830

Thr?Glu?Ser?Thr?Ala?Leu?Thr?Gln?Val?His?Cys?His?Glu?Arg?Ser?Leu

835 840 845

Gly?Asp?Pro?Gln?Gln?Ser?Ala?Leu?Val?Leu?Glu?Ala?Leu?Gly?Val?Lys

850 855 860

Asp?Glu?Gln?Ile?Ala?Thr?Gly?Cys?Cys?Gly?Leu?Ala?Gly?Asn?Trp?Gly

865 870 875 880

Phe?Glu?Lys?Asp?His?Ala?Glu?Met?Ser?Phe?Ala?Leu?Gly?Glu?Arg?Glu

885 890 895

Leu?Phe?Pro?Lys?Val?Arg?Lys?Ala?Glu?Gly?His?Val?Ile?Ala?Asp?Gly

900 905 910

Phe?Ser?Cys?Arg?Thr?Gln?Ile?Glu?Gln?Gly?Thr?Gly?Lys?Gln?Ala?Thr

915 920 925

His?Leu?Ala?Glu?Val?Val?Leu?Ser?Ile?Leu?Glu?Gln?Asn?Asn?Met?Ala

930 935 940

Gln

945

<210>135

<211>1383

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1360)

<223>RXA01901

<400>135

gcatgttgcc?ttctctctgt?gatcgcctcg?ttcttcatcc?aacgcgtcgc?gcaccaagag?60

aactaaaatc?taagtaaaac?ccctccgaaa?ggaaccaccc?atg?gtg?aaa?cgt?caa 115

Met?Val?Lys?Arg?Gln

1 5

ctg?ccc?aac?ccc?gca?gaa?cta?ctc?gaa?ctc?atg?aag?ttc?aaa?aag?cca 163

Leu?Pro?Asn?Pro?Ala?Glu?Leu?Leu?Glu?Leu?Met?Lys?Phe?Lys?Lys?Pro

10 15 20

gag?ctc?aac?ggc?aag?aaa?cga?cgc?cta?gac?tcc?gcg?ctc?acc?atc?tac 211

Glu?Leu?Asn?Gly?Lys?Lys?Arg?Arg?Leu?Asp?Ser?Ala?Leu?Thr?Ile?Tyr

25 30 35

gac?ctg?cgt?aaa?att?gct?aaa?cga?cgc?acc?cca?gct?gcc?gcg?ttc?gac 259

Asp?Leu?Arg?Lys?Ile?Ala?Lys?Arg?Arg?Thr?Pro?Ala?Ala?Ala?Phe?Asp

40 45 50

tac?acc?gac?ggc?gca?gcc?gag?gcc?gaa?ctc?tca?atc?aca?cgc?gca?cgt 307

Tyr?Thr?Asp?Gly?Ala?Ala?Glu?Ala?Glu?Leu?Ser?Ile?Thr?Arg?Ala?Arg

55 60 65

gaa?gca?ttc?gaa?aac?atc?gaa?ttc?cac?cca?gac?atc?ctc?aag?cct?gca 355

Glu?Ala?Phe?Glu?Asn?Ile?Glu?Phe?His?Pro?Asp?Ile?Leu?Lys?Pro?Ala

70 75 80 85

gaa?cac?gta?gac?acc?acc?acc?caa?atc?ctg?ggc?gga?acc?tcc?tcc?atg 403

Glu?His?Val?Asp?Thr?Thr?Thr?Gln?Ile?Leu?Gly?Gly?Thr?Ser?Ser?Met

90 95 100

cca?ttc?ggc?atc?gca?cca?acc?ggc?ttc?acc?cgc?ctc?atg?cag?acc?gaa 451

Pro?Phe?Gly?Ile?Ala?Pro?Thr?Gly?Phe?Thr?Arg?Leu?Met?Gln?Thr?Glu

105 110 115

ggt?gaa?atc?gca?ggt?gcc?gga?gct?gca?ggc?gct?gca?gga?att?cct?ttc 499

Gly?Glu?Ile?Ala?Gly?Ala?Gly?Ala?Ala?Gly?Ala?Ala?Gly?Ile?Pro?Phe

120 125 130

acc?ctg?tcc?acc?ctg?ggc?act?acc?tcc?atc?gaa?gac?gtc?aag?gcc?acc 547

Thr?Leu?Ser?Thr?Leu?Gly?Thr?Thr?Ser?Ile?Glu?Asp?Val?Lys?Ala?Thr

135 140 145

aac?ccc?aac?ggc?cga?aac?tgg?ttc?cag?ctc?tac?gtc?atg?cgc?gac?cgc 595

Asn?Pro?Asn?Gly?Arg?Asn?Trp?Phe?Gln?Leu?Tyr?Val?Met?Arg?Asp?Arg

150 155 160 165

gaa?atc?tcc?tac?ggc?ctc?gtc?gaa?cgc?gca?gcc?aaa?gca?gga?ttc?gac 643

Glu?Ile?Ser?Tyr?Gly?Leu?Val?Glu?Arg?Ala?Ala?Lys?Ala?Gly?Phe?Asp

170 175 180

acc?ctg?atg?ttc?acc?gtg?gat?acc?ccc?atc?gcc?ggc?tac?cgc?atc?cgc 691

Thr?Leu?Met?Phe?Thr?Val?Asp?Thr?Pro?Ile?Ala?Gly?Tyr?Arg?Ile?Arg

185 190 195

gat?tcc?cgc?aac?gga?ttc?tcc?atc?ccg?cca?cag?ctg?acc?cca?tcc?acc 739

Asp?Ser?Arg?Asn?Gly?Phe?Ser?Ile?Pro?Pro?Gln?Leu?Thr?Pro?Ser?Thr

200 205 210

gtg?ctc?aat?gca?atc?cca?cgc?cca?tgg?tgg?tgg?atc?gac?ttc?ctg?acc 787

Val?Leu?Asn?Ala?Ile?Pro?Arg?Pro?Trp?Trp?Trp?Ile?Asp?Phe?Leu?Thr

215 220 225

acc?cca?acc?ctt?gag?ttc?gca?tcc?ctt?tcc?tcg?acc?ggc?gga?acc?gtg 835

Thr?Pro?Thr?Leu?Glu?Phe?Ala?Ser?Leu?Ser?Ser?Thr?Gly?Gly?Thr?Val

230 235 240 245

ggc?gac?ctc?ctc?aac?tcc?gcg?atg?gat?ccc?acc?att?tct?tac?gaa?gac 883

Gly?Asp?Leu?Leu?Asn?Ser?Ala?Met?Asp?Pro?Thr?Ile?Ser?Tyr?Glu?Asp

250 255 260

ctc?aag?gtc?ate?cgt?gaa?atg?tgg?cca?ggc?aag?ctc?gta?gtc?aag?ggt 931

Leu?Lys?Val?Ile?Arg?Glu?Met?Trp?Pro?Gly?Lys?Leu?Val?Val?Lys?Gly

265 270 275

gtc?cag?aac?gtt?gaa?gac?tcc?gtc?aaa?ctc?ctc?gac?caa?ggc?gtc?gac 979

Val?Gln?Asn?Val?Glu?Asp?Ser?Val?Lys?Leu?Leu?Asp?Gln?Gly?Val?Asp

280 285 290

ggc?ctc?atc?ctc?tcc?aac?cac?ggt?ggc?cgt?caa?ctc?gac?cgc?gca?cca 1027

Gly?Leu?Ile?Leu?Ser?Asn?His?Gly?Gly?Arg?Gln?Leu?Asp?Arg?Ala?Pro

295 300 305

gtc?cca?ttc?cac?ctc?ctg?cca?cag?gta?cgc?aag?gaa?gtc?gga?tct?gaa 1075

Val?Pro?Phe?His?Leu?Leu?Pro?Gln?Val?Arg?Lys?Glu?Val?Gly?Ser?Glu

310 315 320 325

cca?acc?atc?atg?atc?gac?acc?ggc?atc?atg?aac?ggc?gcc?gac?atc?gtc 1123

Pro?Thr?Ile?Met?Ile?Asp?Thr?Gly?Ile?Met?Asn?Gly?Ala?Asp?Ile?Val

330 335 340

gca?gcc?gta?gcc?atg?ggc?gct?gac?ttc?acc?ctc?atc?ggt?cgt?gcc?tac 1171

Ala?Ala?Val?Ala?Met?Gly?Ala?Asp?Phe?Thr?Leu?Ile?Gly?Arg?Ala?Tyr

345 350 355

ctc?tac?gga?ctc?atg?gcc?gga?ggc?cgc?gaa?ggc?gtc?gac?cgc?acc?atc 1219

Leu?Tyr?Gly?Leu?Met?Ala?Gly?Gly?Arg?Glu?Gly?Val?Asp?Arg?Thr?Ile

360 365 370

gcc?att?ctc?cgc?agc?gag?atc?acc?cgc?acc?atg?gct?ctc?ctc?ggt?gtt 1267

Ala?Ile?Leu?Arg?Ser?Glu?Ile?Thr?Arg?Thr?Met?Ala?Leu?Leu?Gly?Val

375 380 385

tcc?tcc?ctc?gaa?gaa?ctc?gag?cca?cgc?cac?gtc?acc?cag?ctg?gcc?aag 1315

Ser?Ser?Leu?Glu?Glu?Leu?Glu?Pro?Arg?His?Val?Thr?Gln?Leu?Ala?Lys

390 395 400 405

atg?gtt?cca?gtt?tct?gac?gca?act?cgt?tct?gca?gcg?gcg?gag?att 1360

Met?Val?Pro?Val?Ser?Asp?Ala?Thr?Arg?Ser?Ala?Ala?Ala?Glu?Ile

410 415 420

taaaagtttc?tctccttagc?tat 1383

<210>136

<211>420

<212>PRT

＜213〉Corynebacterium glutamicum

<400>136

Met?Val?Lys?Arg?Gln?Leu?Pro?Asn?Pro?Ala?Glu?Leu?Leu?Glu?Leu?Met

1 5 10 15

Lys?Phe?Lys?Lys?Pro?Glu?Leu?Asn?Gly?Lys?Lys?Arg?Arg?Leu?Asp?Ser

20 25 30

Ala?Leu?Thr?Ile?Tyr?Asp?Leu?Arg?Lys?Ile?Ala?Lys?Arg?Arg?Thr?Pro

35 40 45

Ala?Ala?Ala?Phe?Asp?Tyr?Thr?Asp?Gly?Ala?Ala?Glu?Ala?Glu?Leu?Ser

50 55 60

Ile?Thr?Arg?Ala?Arg?Glu?Ala?Phe?Glu?Asn?Ile?Glu?Phe?His?Pro?Asp

65 70 75 80

Ile?Leu?Lys?Pro?Ala?Glu?His?Val?Asp?Thr?Thr?Thr?Gln?Ile?Leu?Gly

85 90 95

Gly?Thr?Ser?Ser?Met?Pro?Phe?Gly?Ile?Ala?Pro?Thr?Gly?Phe?Thr?Arg

100 105 110

Leu?Met?Gln?Thr?Glu?Gly?Glu?Ile?Ala?Gly?Ala?Gly?Ala?Ala?Gly?Ala

115 120 125

Ala?Gly?Ile?Pro?Phe?Thr?Leu?Ser?Thr?Leu?Gly?Thr?Thr?Ser?Ile?Glu

130 135 140

Asp?Val?Lys?Ala?Thr?Asn?Pro?Asn?Gly?Arg?Asn?Trp?Phe?Gln?Leu?Tyr

145 150 155 160

Val?Met?Arg?Asp?Arg?Glu?Ile?Ser?Tyr?Gly?Leu?Val?Glu?Arg?Ala?Ala

165 170 175

Lys?Ala?Gly?Phe?Asp?Thr?Leu?Met?Phe?Thr?Val?Asp?Thr?Pro?Ile?Ala

180 185 190

Gly?Tyr?Arg?Ile?Arg?Asp?Ser?Arg?Asn?Gly?Phe?Ser?Ile?Pro?Pro?Gln

195 200 205

Leu?Thr?Pro?Ser?Thr?Val?Leu?Asn?Ala?Ile?Pro?Arg?Pro?Trp?Trp?Trp

210 215 220

Ile?Asp?Phe?Leu?Thr?Thr?Pro?Thr?Leu?Glu?Phe?Ala?Ser?Leu?Ser?Ser

225 230 235 240

Thr?Gly?Gly?Thr?Val?Gly?Asp?Leu?Leu?Asn?Ser?Ala?Met?Asp?Pro?Thr

245 250 255

Ile?Ser?Tyr?Glu?Asp?Leu?Lys?Val?Ile?Arg?Glu?Met?Trp?Pro?Gly?Lys

260 265 270

Leu?Val?Val?Lys?Gly?Val?Gln?Asn?Val?Glu?Asp?Ser?Val?Lys?Leu?Leu

275 280 285

Asp?Gln?Gly?Val?Asp?Gly?Leu?Ile?Leu?Ser?Asn?His?Gly?Gly?Arg?Gln

290 295 300

Leu?Asp?Arg?Ala?Pro?Val?Pro?Phe?His?Leu?Leu?Pro?Gln?Val?Arg?Lys

305 310 315 320

Glu?Val?Gly?Ser?Glu?Pro?Thr?Ile?Met?Ile?Asp?Thr?Gly?Ile?Met?Asn

325 330 335

Gly?Ala?Asp?Ile?Val?Ala?Ala?Val?Ala?Met?Gly?Ala?Asp?Phe?Thr?Leu

340 345 350

Ile?Gly?Arg?Ala?Tyr?Leu?Tyr?Gly?Leu?Met?Ala?Gly?Gly?Arg?Glu?Gly

355 360 365

Val?Asp?Arg?Thr?Ile?Ala?Ile?Leu?Arg?Ser?Glu?Ile?Thr?Arg?Thr?Met

370 375 380

Ala?Leu?Leu?Gly?Val?Ser?Ser?Leu?Glu?Glu?Leu?Glu?Pro?Arg?His?Val

385 390 395 400

Thr?Gln?Leu?Ala?Lys?Met?Val?Pro?Val?Ser?Asp?Ala?Thr?Arg?Ser?Ala

405 410 415

Ala?Ala?Glu?Ile

420

<210>137

<211>1836

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1813)

<223>RXN01952

<400>137

ccatcaaaaa?atgaacgacc?gcggactagc?tcggatcaag?gcgacatccc?ctcagcatca?60

tgacgcgctt?gtgatgcaac?tgaatatagg?aagcttagag?atg?acg?caa?cca?gga 115

Met?Thr?Gln?Pro?Gly

1 5

cag?acc?acc?acg?act?tcg?cac?gaa?gcg?atc?gat?gcg?ttc?aag?aga?atc 163

Gln?Thr?Thr?Thr?Thr?Ser?His?Glu?Ala?Ile?Asp?Ala?Phe?Lys?Arg?Ile

10 15 20

gtc?ggc?gac?gaa?cat?gta?ctg?acc?tct?gag?cgt?gcc?acg?atg?cca?ttc 211

Val?Gly?Asp?Glu?His?Val?Leu?Thr?Ser?Glu?Arg?Ala?Thr?Met?Pro?Phe

25 30 35

agc?aaa?ggc?tat?cga?ttc?ggc?gga?gga?cca?gtc?ttc?gcc?gtg?gtg?cgc 259

Ser?Lys?Gly?Tyr?Arg?Phe?Gly?Gly?Gly?Pro?Val?Phe?Ala?Val?Val?Arg

40 45 50

ccc?ggc?acg?ctg?gtc?gag?atg?tgg?cgg?gcg?ctg?cag?gta?tcc?gtc?gac 307

Pro?Gly?Thr?Leu?Val?Glu?Met?Trp?Arg?Ala?Leu?Gln?Val?Ser?Val?Asp

55 60 65

aac?aac?ctc?atc?gtc?atc?ccg?cag?gca?tcg?aac?acg?ggc?ctg?act?ggt 355

Asn?Asn?Leu?Ile?Val?Ile?Pro?Gln?Ala?Ser?Asn?Thr?Gly?Leu?Thr?Gly

70 75 80 85

gga?tcc?ggc?ccc?ggc?ttc?caa?gac?tac?gat?cgc?ccc?att?gtg?atc?atc 403

Gly?Ser?Gly?Pro?Gly?Phe?Gln?Asp?Tyr?Asp?Arg?Pro?Ile?Val?Ile?Ile

90 95 100

tcg?act?cac?cgc?atc?gat?gag?gtg?cac?ctc?atc?aac?gac?gcg?cgc?gag 451

Ser?Thr?His?Arg?Ile?Asp?Glu?Val?His?Leu?Ile?Asn?Asp?Ala?Arg?Glu

105 110 115

gcg?atc?tcg?ctc?gcg?ggc?acc?ccg?ctg?aca?cac?ctg?acc?gac?gcg?ctc 499

Ala?Ile?Ser?Leu?Ala?Gly?Thr?Pro?Leu?Thr?His?Leu?Thr?Asp?Ala?Leu

120 125 130

gcc?aag?cac?cag?cgc?gag?ccg?cac?tcg?gtg?atc?ggg?tcg?aca?tca?atc 547

Ala?Lys?His?Gln?Arg?Glu?Pro?His?Ser?Val?Ile?Gly?Ser?Thr?Ser?Ile

135 140 145

ggc?gcc?tcg?gtc?atc?ggc?ggc?atc?gcg?aac?aac?tcg?ggc?ggc?agc?cag 595

Gly?Ala?Ser?Val?Ile?Gly?Gly?Ile?Ala?Asn?Asn?Ser?Gly?Gly?Ser?Gln

150 155 160 165

att?cgc?aag?ggt?ccg?gca?ttc?acg?cgc?gaa?gcg?atc?ttc?gcc?cgc?gtc 643

Ile?Arg?Lys?Gly?Pro?Ala?Phe?Thr?Arg?Glu?Ala?Ile?Phe?Ala?Arg?Val

170 175 180

aac?gac?gac?ggc?aag?gtc?gag?ctg?gtc?aat?cac?ctg?ggc?atc?tcg?ctc 691

Asn?Asp?Asp?Gly?Lys?Val?Glu?Leu?Val?Asn?His?Leu?Gly?Ile?Ser?Leu

185 190 195

gga?gac?gac?cct?gag?gtc?gca?ctc?gac?cgt?cta?cag?cgc?ggc?gag?tgg 739

Gly?Asp?Asp?Pro?Glu?Val?Ala?Leu?Asp?Arg?Leu?Gln?Arg?Gly?Glu?Trp

200 205 210

tct?ccc?gag?gat?gtc?acc?cca?gct?ccc?gaa?gac?tcg?aac?gag?acc?gag 787

Ser?Pro?Glu?Asp?Val?Thr?Pro?Ala?Pro?Glu?Asp?Ser?Asn?Glu?Thr?Glu

215 220 225

tac?gcc?gag?cac?ttg?cgc?aag?atc?gtg?cct?tcg?cct?gct?cgc?tac?aat 835

Tyr?Ala?Glu?His?Leu?Arg?Lys?Ile?Val?Pro?Ser?Pro?Ala?Arg?Tyr?Asn

230 235 240 245

gcg?aac?ccc?gag?tac?ctg?ttc?gag?gct?tcc?ggc?tcg?gcc?ggc?aag?ctg 883

Ala?Asn?Pro?Glu?Tyr?Leu?Phe?Glu?Ala?Ser?Gly?Ser?Ala?Gly?Lys?Leu

250 255 260

atg?gtg?ttc?gcg?gtg?cgc?acc?cgc?acc?ttc?cct?cgc?gaa?gtg?cac?ccg 931

Met?Val?Phe?Ala?Val?Arg?Thr?Arg?Thr?Phe?Pro?Arg?Glu?Val?His?Pro

265 270 275

acc?gtg?ttt?tac?atc?ggc?acg?aac?aac?acg?cac?gag?ctc?gaa?gag?atc 979

Thr?Val?Phe?Tyr?Ile?Gly?Thr?Asn?Asn?Thr?His?Glu?Leu?Glu?Glu?Ile

280 285 290

cgt?cgg?ttg?ttc?ctc?gaa?gcc?gac?atg?ccg?ctg?cct?atc?tct?ggt?gag 1027

Arg?Arg?Leu?Phe?Leu?Glu?Ala?Asp?Met?Pro?Leu?Pro?Ile?Ser?Gly?Glu

295 300 305

tac?atg?ggc?cgc?agt?gcc?ttc?gac?ttg?gcc?gag?aag?tac?ggc?aaa?gac 1075

Tyr?Met?Gly?Arg?Ser?Ala?Phe?Asp?Leu?Ala?Glu?Lys?Tyr?Gly?Lys?Asp

310 315 320 325

acc?ttc?gtc?ttc?ctg?aag?ttc?atg?agt?cca?gcg?ctg?cag?acg?cgc?atg 1123

Thr?Phe?Val?Phe?Leu?Lys?Phe?Met?Ser?Pro?Ala?Leu?Gln?Thr?Arg?Met

330 335 340

ttc?tcg?ttc?aag?acg?tgg?gcc?aac?ggc?ttg?ttc?tcg?aag?att?ccc?ggc 1171

Phe?Ser?Phe?Lys?Thr?Trp?Ala?Asn?Gly?Leu?Phe?Ser?Lys?Ile?Pro?Gly

345 350 355

att?ggt?ccg?acc?ttc?gcc?gac?acg?gta?tcg?caa?gcc?atg?ttc?agc?gtg 1219

Ile?Gly?Pro?Thr?Phe?Ala?Asp?Thr?Val?Ser?Gln?Ala?Met?Phe?Ser?Val

360 365 370

ctg?ccc?aac?cag?ctg?ccc?aag?cgc?atg?atg?gag?tac?cgc?aac?cgt?ttc 1267

Leu?Pro?Asn?Gln?Leu?Pro?Lys?Arg?Met?Met?Glu?Tyr?Arg?Asn?Arg?Phe

375 380 385

gag?cat?cac?ctg?ctg?ctc?acc?gtc?agc?gag?tcg?cag?aag?gcc?gcg?agc 1315

Glu?His?His?Leu?Leu?Leu?Thr?Val?Ser?Glu?Ser?Gln?Lys?Ala?Ala?Ser

390 395 400 405

gag?aag?atg?ctc?aag?gag?ttc?ttc?gca?gag?ccc?gag?cac?act?ggt?gag 1363

Glu?Lys?Met?Leu?Lys?Glu?Phe?Phe?Ala?Glu?Pro?Glu?His?Thr?Gly?Glu

410 415 420

ttc?ttc?atc?tgc?acg?tct?gat?gaa?gaa?aag?agc?gcg?tcg?ctc?aac?cgg 1411

Phe?Phe?Ile?Cys?Thr?Ser?Asp?Glu?Glu?Lys?Ser?Ala?Ser?Leu?Asn?Arg

425 430 435

ttc?ggc?gcg?gcc?agt?gcc?gcc?act?cgc?tac?gcc?gcg?ttg?aag?cgc?cgg 1459

Phe?Gly?Ala?Ala?Ser?Ala?Ala?Thr?Arg?Tyr?Ala?Ala?Leu?Lys?Arg?Arg

440 445 450

cac?atc?gca?ggg?ctc?atc?ccc?atc?gat?gtg?gcc?ctg?cgt?cgc?gac?gat 1507

His?Ile?Ala?Gly?Leu?Ile?Pro?Ile?Asp?Val?Ala?Leu?Arg?Arg?Asp?Asp

455 460 465

tgg?aac?tgg?ctc?gag?gtg?ctg?ccg?gag?gag?atc?gac?gac?cag?ctt?gag 1555

Trp?Asn?Trp?Leu?Glu?Val?Leu?Pro?Glu?Glu?Ile?Asp?Asp?Gln?Leu?Glu

470 475 480 485

gtc?aag?gcg?tat?tac?ggg?cac?ttc?ttc?tgc?cat?gtg?atg?cac?cag?gac 1603

Val?Lys?Ala?Tyr?Tyr?Gly?His?Phe?Phe?Cys?His?Val?Met?His?Gln?Asp

490 495 500

tat?gtc?gcc?aag?cag?ggc?gtg?gat?ctc?gag?gcg?ctg?cac?gac?cgc?atc 1651

Tyr?Val?Ala?Lys?Gln?Gly?Val?Asp?Leu?Glu?Ala?Leu?His?Asp?Arg?Ile

505 510 515

cag?cac?ctg?ctg?gag?gag?cgc?ggc?gcg?aag?ctg?ccc?gcc?gag?cac?aac 1699

Gln?His?Leu?Leu?Glu?Glu?Arg?Gly?Ala?Lys?Leu?Pro?Ala?Glu?His?Asn

520 525 530

tac?ggt?cgc?atg?tac?aag?ctg?ccg?gag?tcc?atg?gaa?gag?cac?ttc?aag 1747

Tyr?Gly?Arg?Met?Tyr?Lys?Leu?Pro?Glu?Ser?Met?Glu?Glu?His?Phe?Lys

535 540 545

gag?ctc?gat?ccg?acg?aat?acg?ttc?aac?gcc?ggt?atc?ggc?ggc?acg?tcg 1795

Glu?Leu?Asp?Pro?Thr?Asn?Thr?Phe?Asn?Ala?Gly?Ile?Gly?Gly?Thr?Ser

550 555 560 565

ccg?cac?aag?gac?tgg?gcc?taagtcccca?aggtagcgcg?acg 1836

Pro?His?Lys?Asp?Trp?Ala

570

<210>138

<211>571

<212>PRT

＜213〉Corynebacterium glutamicum

<400>138

Met?Thr?Gln?Pro?Gly?Gln?Thr?Thr?Thr?Thr?Ser?His?Glu?Ala?Ile?Asp

1 5 10 15

Ala?Phe?Lys?Arg?Ile?Val?Gly?Asp?Glu?His?Val?Leu?Thr?Ser?Glu?Arg

20 25 30

Ala?Thr?Met?Pro?Phe?Ser?Lys?Gly?Tyr?Arg?Phe?Gly?Gly?Gly?Pro?Val

35 40 45

Phe?Ala?Val?Val?Arg?Pro?Gly?Thr?Leu?Val?Glu?Met?Trp?Arg?Ala?Leu

50 55 60

Gln?Val?Ser?Val?Asp?Asn?Asn?Leu?Ile?Val?Ile?Pro?Gln?Ala?Ser?Asn

65 70 75 80

Thr?Gly?Leu?Thr?Gly?Gly?Ser?Gly?Pro?Gly?Phe?Gln?Asp?Tyr?Asp?Arg

85 90 95

Pro?Ile?Val?Ile?Ile?Ser?Thr?His?Arg?Ile?Asp?Glu?Val?His?Leu?Ile

100 105 110

Asn?Asp?Ala?Arg?Glu?Ala?Ile?Ser?Leu?Ala?Gly?Thr?Pro?Leu?Thr?His

115 120 125

Leu?Thr?Asp?Ala?Leu?Ala?Lys?His?Gln?Arg?Glu?Pro?His?Ser?Val?Ile

130 135 140

Gly?Ser?Thr?Ser?Ile?Gly?Ala?Ser?Val?Ile?Gly?Gly?Ile?Ala?Asn?Asn

145 150 155 160

Ser?Gly?Gly?Ser?Gln?Ile?Arg?Lys?Gly?Pro?Ala?Phe?Thr?Arg?Glu?Ala

165 170 175

Ile?Phe?Ala?Arg?Val?Asn?Asp?Asp?Gly?Lys?Val?Glu?Leu?Val?Asn?His

180 185 190

Leu?Gly?Ile?Ser?Leu?Gly?Asp?Asp?Pro?Glu?Val?Ala?Leu?Asp?Arg?Leu

195 200 205

Gln?Arg?Gly?Glu?Trp?Ser?Pro?Glu?Asp?Val?Thr?Pro?Ala?Pro?Glu?Asp

210 215 220

Ser?Asn?Glu?Thr?Glu?Tyr?Ala?Glu?His?Leu?Arg?Lys?Ile?Val?Pro?Ser

225 230 235 240

Pro?Ala?Arg?Tyr?Asn?Ala?Asn?Pro?Glu?Tyr?Leu?Phe?Glu?Ala?Ser?Gly

245 250 255

Ser?Ala?Gly?Lys?Leu?Met?Val?Phe?Ala?Val?Arg?Thr?Arg?Thr?Phe?Pro

260 265 270

Arg?Glu?Val?His?Pro?Thr?Val?Phe?Tyr?Ile?Gly?Thr?Asn?Asn?Thr?His

275 280 285

Glu?Leu?Glu?Glu?Ile?Arg?Arg?Leu?Phe?Leu?Glu?Ala?Asp?Met?Pro?Leu

290 295 300

Pro?Ile?Ser?Gly?Glu?Tyr?Met?Gly?Arg?Ser?Ala?Phe?Asp?Leu?Ala?Glu

305 310 315 320

Lys?Tyr?Gly?Lys?Asp?Thr?Phe?Val?Phe?Leu?Lys?Phe?Met?Ser?Pro?Ala

325 330 335

Leu?Gln?Thr?Arg?Met?Phe?Ser?Phe?Lys?Thr?Trp?Ala?Asn?Gly?Leu?Phe

340 345 350

Ser?Lys?Ile?Pro?Gly?Ile?Gly?Pro?Thr?Phe?Ala?Asp?Thr?Val?Ser?Gln

355 360 365

Ala?Met?Phe?Ser?Val?Leu?Pro?Asn?Gln?Leu?Pro?Lys?Arg?Met?Met?Glu

370 375 380

Tyr?Arg?Asn?Arg?Phe?Glu?His?His?Leu?Leu?Leu?Thr?Val?Ser?Glu?Ser

385 390 395 400

Gln?Lys?Ala?Ala?Ser?Glu?Lys?Met?Leu?Lys?Glu?Phe?Phe?Ala?Glu?Pro

405 410 415

Glu?His?Thr?Gly?Glu?Phe?Phe?Ile?Cys?Thr?Ser?Asp?Glu?Glu?Lys?Ser

420 425 430

Ala?Ser?Leu?Asn?Arg?Phe?Gly?Ala?Ala?Ser?Ala?Ala?Thr?Arg?Tyr?Ala

435 440 445

Ala?Leu?Lys?Arg?Arg?His?Ile?Ala?Gly?Leu?Ile?Pro?Ile?Asp?Val?Ala

450 455 460

Leu?Arg?Arg?Asp?Asp?Trp?Asn?Trp?Leu?Glu?Val?Leu?Pro?Glu?Glu?Ile

465 470 475 480

Asp?Asp?Gln?Leu?Glu?Val?Lys?Ala?Tyr?Tyr?Gly?His?Phe?Phe?Cys?His

485 490 495

Val?Met?His?Gln?Asp?Tyr?Val?Ala?Lys?Gln?Gly?Val?Asp?Leu?Glu?Ala

500 505 510

Leu?His?Asp?Arg?Ile?Gln?His?Leu?Leu?Glu?Glu?Arg?Gly?Ala?Lys?Leu

515 520 525

Pro?Ala?Glu?His?Asn?Tyr?Gly?Arg?Met?Tyr?Lys?Leu?Pro?Glu?Ser?Met

530 535 540

Glu?Glu?His?Phe?Lys?Glu?Leu?Asp?Pro?Thr?Asn?Thr?Phe?Asn?Ala?Gly

545 550 555 560

Ile?Gly?Gly?Thr?Ser?Pro?His?Lys?Asp?Trp?Ala

565 570

<210>139

<211>239

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(216)

<223>FRXA01952

<400>139

cca?gga?cta?tgt?cgc?caa?gca?ggg?cgt?gga?tct?caa?ggc?gct?gac?gac 48

Pro?Gly?Leu?Cys?Arg?Gln?Ala?Gly?Arg?Gly?Ser?Gln?Gly?Ala?Asp?Asp

1 5 10 15

cgc?atc?cag?cac?ttg?ctg?gag?gag?cac?ggc?aag?aag?ctg?ccc?gcc?gag 96

Arg?Ile?Gln?His?Leu?Leu?Glu?Glu?His?Gly?Lys?Lys?Leu?Pro?Ala?Glu

20 25 30

cac?aac?tac?ggt?cgc?atg?tac?aag?ctg?ccg?gag?tcc?atg?gaa?gag?cac 144

His?Asn?Tyr?Gly?Arg?Met?Tyr?Lys?Leu?Pro?Glu?Ser?Met?Glu?Glu?His

35 40 45

ttc?aag?gag?ctc?gat?ccg?acg?aat?acg?ttc?aac?gcc?ggt?atc?ggc?ggc 192

Phe?Lys?Glu?Leu?Asp?Pro?Thr?Asn?Thr?Phe?Asn?Ala?Gly?Ile?Gly?Gly

50 55 60

acg?tcg?ccg?cac?aag?gac?tgg?gcc?taagtcccca?aggtagcgcg?acg 239

Thr?Ser?Pro?His?Lys?Asp?Trp?Ala

65 70

<210>140

<211>72

<212>PRT

＜213〉Corynebacterium glutamicum

<400>140

Pro?Gly?Leu?Cys?Arg?Gln?Ala?Gly?Arg?Gly?Ser?Gln?Gly?Ala?Asp?Asp

1 5 10 15

Arg?Ile?Gln?His?Leu?Leu?Glu?Glu?His?Gly?Lys?Lys?Leu?Pro?Ala?Glu

20 25 30

His?Asn?Tyr?Gly?Arg?Met?Tyr?Lys?Leu?Pro?Glu?Ser?Met?Glu?Glu?His

35 40 45

Phe?Lys?Glu?Leu?Asp?Pro?Thr?Asn?Thr?Phe?Asn?Ala?Gly?Ile?Gly?Gly

50 55 60

Thr?Ser?Pro?His?Lys?Asp?Trp?Ala

65 70

<210>141

<211>1699

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1699)

<223>FRXA01955

<400>141

ccatcaaaaa?atgaacgacc?gcggactagc?tcggatcaag?gcgacatccc?ctcagcatca?60

tgacgcgctt?gtgatgcaac?tgaatatagg?aagcttagag?atg?acg?caa?cca?gga 115

Met?Thr?Gln?Pro?Gly

1 5

cag?acc?acc?acg?act?tcg?cac?gaa?gcg?atc?gat?gcg?ttc?aag?aga?atc 163

Gln?Thr?Thr?Thr?Thr?Ser?His?Glu?Ala?Ile?Asp?Ala?Phe?Lys?Arg?Ile

10 15 20

gtc?ggc?gac?gaa?cat?gta?ctg?acc?tct?gag?cgt?gcc?acg?atg?cca?ttc 211

Val?Gly?Asp?Glu?His?Val?Leu?Thr?Ser?Glu?Arg?Ala?Thr?Met?Pro?Phe

25 30 35

agc?aaa?ggc?tat?cga?ttc?ggc?gga?gga?cca?gtc?ttc?gcc?gtg?gtg?cgc 259

Ser?Lys?Gly?Tyr?Arg?Phe?Gly?Gly?Gly?Pro?Val?Phe?Ala?Val?Val?Arg

40 45 50

ccc?ggc?acg?ctg?gtc?gag?atg?tgg?cgg?gcg?ctg?cag?gta?tcc?gtc?gac 307

Pro?Gly?Thr?Leu?Val?Glu?Met?Trp?Arg?Ala?Leu?Gln?Val?Ser?Val?Asp

55 60 65

aac?aac?ctc?atc?gtc?atc?ccg?cag?gca?tcg?aac?acg?ggc?ctg?act?ggt 355

Asn?Asn?Leu?Ile?Val?Ile?Pro?Gln?Ala?Ser?Asn?Thr?Gly?Leu?Thr?Gly

70 75 80 85

gga?tcc?ggc?ccc?ggc?ttc?caa?gac?tac?gat?cgc?ccc?att?gtg?atc?atc 403

Gly?Ser?Gly?Pro?Gly?Phe?Gln?Asp?Tyr?Asp?Arg?Pro?Ile?Val?Ile?Ile

90 95 100

tcg?act?cac?cgc?atc?gat?gag?gtg?cac?ctc?atc?aac?gac?gcg?cgc?gag 451

Ser?Thr?His?Arg?Ile?Asp?Glu?Val?His?Leu?Ile?Asn?Asp?Ala?Arg?Glu

105 110 115

gcg?atc?tcg?ctc?gcg?ggc?acc?ccg?ctg?aca?cac?ctg?acc?gac?gcg?ctc 499

Ala?Ile?Ser?Leu?Ala?Gly?Thr?Pro?Leu?Thr?His?Leu?Thr?Asp?Ala?Leu

120 125 130

gcc?aag?cac?cag?cgc?gag?ccg?cac?tcg?gtg?atc?ggg?tcg?aca?tca?atc 547

Ala?Lys?His?Gln?Arg?Glu?Pro?His?Ser?Val?Ile?Gly?Ser?Thr?Ser?Ile

135 140 145

ggc?gcc?tcg?gtc?atc?ggc?ggc?atc?gcg?aac?aac?tcg?ggc?ggc?agc?cag 595

Gly?Ala?Ser?Val?Ile?Gly?Gly?Ile?Ala?Asn?Asn?Ser?Gly?Gly?Ser?Gln

150 155 160 165

att?cgc?aag?ggt?ccg?gca?ttc?acg?cgc?gaa?gcg?atc?ttc?gcc?cgc?gtc 643

Ile?Arg?Lys?Gly?Pro?Ala?Phe?Thr?Arg?Glu?Ala?Ile?Phe?Ala?Arg?Val

170 175 180

aac?gac?gac?ggc?aag?gtc?gag?ctg?gtc?aat?cac?ctg?ggc?atc?tcg?ctc 691

Asn?Asp?Asp?Gly?Lys?Val?Glu?Leu?Val?Asn?His?Leu?Gly?Ile?Ser?Leu

185 190 195

gga?gac?gac?cct?gag?gtc?gca?ctc?gac?cgt?cta?cag?cgc?ggc?gag?tgg 739

Gly?Asp?Asp?Pro?Glu?Val?Ala?Leu?Asp?Arg?Leu?Gln?Arg?Gly?Glu?Trp

200 205 210

tct?ccc?gag?gat?gtc?acc?cca?gct?ccc?gaa?gac?tcg?aac?gag?acc?gag 787

Ser?Pro?Glu?Asp?Val?Thr?Pro?Ala?Pro?Glu?Asp?Ser?Asn?Glu?Thr?Glu

215 220 225

tac?gcc?gag?cac?ttg?cgc?aag?atc?gtg?cct?tcg?cct?gct?cgc?tac?aat 835

Tyr?Ala?Glu?His?Leu?Arg?Lys?Ile?Val?Pro?Ser?Pro?Ala?Arg?Tyr?Asn

230 235 240 245

gcg?aac?ccc?gag?tac?ctg?ttc?gag?gct?tcc?ggc?tcg?gcc?ggc?aag?ctg 883

Ala?Asn?Pro?Glu?Tyr?Leu?Phe?Glu?Ala?Ser?Gly?Ser?Ala?Gly?Lys?Leu

250 255 260

atg?gtg?ttc?gcg?gtg?cgc?acc?cgc?acc?ttc?cct?cgc?gaa?gtg?cac?ccg 931

Met?Val?Phe?Ala?Val?Arg?Thr?Arg?Thr?Phe?Pro?Arg?Glu?Val?His?Pro

265 270 275

acc?gtg?ttt?tac?atc?ggc?acg?aac?aac?acg?cac?gag?ctc?gaa?gag?atc 979

Thr?Val?Phe?Tyr?Ile?Gly?Thr?Asn?Asn?Thr?His?Glu?Leu?Glu?Glu?Ile

280 285 290

cgt?cgg?ttg?ttc?ctc?gaa?gcc?gac?atg?ccg?ctg?cct?atc?tct?ggt?gag 1027

Arg?Arg?Leu?Phe?Leu?Glu?Ala?Asp?Met?Pro?Leu?Pro?Ile?Ser?Gly?Glu

295 300 305

tac?atg?ggc?cgc?agt?gcc?ttc?gac?ttg?gcc?gag?aag?tac?ggc?aaa?gac 1075

Tyr?Met?Gly?Arg?Ser?Ala?Phe?Asp?Leu?Ala?Glu?Lys?Tyr?Gly?Lys?Asp

310 315 320 325

acc?ttc?gtc?ttc?ctg?aag?ttc?atg?agt?cca?gcg?ctg?cag?acg?cgc?atg 1123

Thr?Phe?Val?Phe?Leu?Lys?Phe?Met?Ser?Pro?Ala?Leu?Gln?Thr?Arg?Met

330 335 340

ttc?tcg?ttc?aag?acg?tgg?gcc?aac?ggc?ttg?ttc?tcg?aag?att?ccc?ggc 1171

Phe?Ser?Phe?Lys?Thr?Trp?Ala?Asn?Gly?Leu?Phe?Ser?Lys?Ile?Pro?Gly

345 350 355

att?ggt?ccg?acc?ttc?gcc?gac?acg?gta?tcg?caa?gcc?atg?ttc?agc?gtg 1219

Ile?Gly?Pro?Thr?Phe?Ala?Asp?Thr?Val?Ser?Gln?Ala?Met?Phe?Ser?Val

360 365 370

ctg?ccc?aac?cag?ctg?ccc?aag?cgc?atg?atg?gag?tac?cgc?aac?cgt?ttc 1267

Leu?Pro?Asn?Gln?Leu?Pro?Lys?Arg?Met?Met?Glu?Tyr?Arg?Asn?Arg?Phe

375 380 385

gag?cat?cac?ctg?ctg?ctc?acc?gtc?agc?gag?tcg?cag?aag?gcc?gcg?agc 1315

Glu?His?His?Leu?Leu?Leu?Thr?Val?Ser?Glu?Ser?Gln?Lys?Ala?Ala?Ser

390 395 400 405

gag?aag?atg?ctc?aag?gag?ttc?ttc?gca?gag?ccc?gag?cac?act?ggt?gag 1363

Glu?Lys?Met?Leu?Lys?Glu?Phe?Phe?Ala?Glu?Pro?Glu?His?Thr?Gly?Glu

410 415 420

ttc?ttc?atc?tgc?acg?tct?gat?gaa?gaa?aag?agc?gcg?tcg?ctc?aac?cgg 1411

Phe?Phe?Ile?Cys?Thr?Ser?Asp?Glu?Glu?Lys?Ser?Ala?Ser?Leu?Asn?Arg

425 430 435

ttc?ggc?gcg?gcc?agt?gcc?gcc?act?cgc?tac?gcc?gcg?ttg?aag?cgc?cgg 1459

Phe?Gly?Ala?Ala?Ser?Ala?Ala?Thr?Arg?Tyr?Ala?Ala?Leu?Lys?Arg?Arg

440 445 450

cac?atc?gca?ggg?ctc?atc?ccc?atc?gat?gtg?gcc?ctg?cgt?cgc?gac?gat 1507

His?Ile?Ala?Gly?Leu?Ile?Pro?Ile?Asp?Val?Ala?Leu?Arg?Arg?Asp?Asp

455 460 465

tgg?aac?tgg?ctc?gag?gtg?ctg?ccg?gag?gag?atc?gac?gac?cag?ctt?gag 1555

Trp?Asn?Trp?Leu?Glu?Val?Leu?Pro?Glu?Glu?Ile?Asp?Asp?Gln?Leu?Glu

470 475 480 485

gtc?aag?gcg?tat?tac?ggg?cac?ttc?ttc?tgc?cat?gtg?atg?cac?cag?gac 1603

Val?Lys?Ala?Tyr?Tyr?Gly?His?Phe?Phe?Cys?His?Val?Met?His?Gln?Asp

490 495 500

tat?gtc?gcc?aag?cag?ggc?gtg?gat?ctc?gag?gcg?ctg?cac?gac?cgc?atc 1651

Tyr?Val?Ala?Lys?Gln?Gly?Val?Asp?Leu?Glu?Ala?Leu?His?Asp?Arg?Ile

505 510 515

cag?cac?ctg?ctg?gag?gag?cgc?ggc?gcg?aag?ctg?ccc?gcc?gag?cac?aac 1699

Gln?His?Leu?Leu?Glu?Glu?Arg?Gly?Ala?Lys?Leu?Pro?Ala?Glu?His?Asn

520 525 530

<210>142

<211>533

<212>PRT

＜213〉Corynebacterium glutamicum

<400>142

Met?Thr?Gln?Pro?Gly?Gln?Thr?Thr?Thr?Thr?Ser?His?Glu?Ala?Ile?Asp

1 5 10 15

Ala?Phe?Lys?Arg?Ile?Val?Gly?Asp?Glu?His?Val?Leu?Thr?Ser?Glu?Arg

20 25 30

Ala?Thr?Met?Pro?Phe?Ser?Lys?Gly?Tyr?Arg?Phe?Gly?Gly?Gly?Pro?Val

35 40 45

Phe?Ala?Val?Val?Arg?Pro?Gly?Thr?Leu?Val?Glu?Met?Trp?Arg?Ala?Leu

50 55 60

Gln?Val?Ser?Val?Asp?Asn?Asn?Leu?Ile?Val?Ile?Pro?Gln?Ala?Ser?Asn

65 70 75 80

Thr?Gly?Leu?Thr?Gly?Gly?Ser?Gly?Pro?Gly?Phe?Gln?Asp?Tyr?Asp?Arg

85 90 95

Pro?Ile?Val?Ile?Ile?Ser?Thr?His?Arg?Ile?Asp?Glu?Val?His?Leu?Ile

100 105 110

Asn?Asp?Ala?Arg?Glu?Ala?Ile?Ser?Leu?Ala?Gly?Thr?Pro?Leu?Thr?His

115 120 125

Leu?Thr?Asp?Ala?Leu?Ala?Lys?His?Gln?Arg?Glu?Pro?His?Ser?Val?Ile

130 135 140

Gly?Ser?Thr?Ser?Ile?Gly?Ala?Ser?Val?Ile?Gly?Gly?Ile?Ala?Asn?Asn

145 150 155 160

Ser?Gly?Gly?Ser?Gln?Ile?Arg?Lys?Gly?Pro?Ala?Phe?Thr?Arg?Glu?Ala

165 170 175

Ile?Phe?Ala?Arg?Val?Asn?Asp?Asp?Gly?Lys?Val?Glu?Leu?Val?Asn?His

180 185 190

Leu?Gly?Ile?Ser?Leu?Gly?Asp?Asp?Pro?Glu?Val?Ala?Leu?Asp?Arg?Leu

195 200 205

Gln?Arg?Gly?Glu?Trp?Ser?Pro?Glu?Asp?Val?Thr?Pro?Ala?Pro?Glu?Asp

210 215 220

Ser?Asn?Glu?Thr?Glu?Tyr?Ala?Glu?His?Leu?Arg?Lys?Ile?Val?Pro?Ser

225 230 235 240

Pro?Ala?Arg?Tyr?Asn?Ala?Asn?Pro?Glu?Tyr?Leu?Phe?Glu?Ala?Ser?Gly

245 250 255

Ser?Ala?Gly?Lys?Leu?Met?Val?Phe?Ala?Val?Arg?Thr?Arg?Thr?Phe?Pro

260 265 270

Arg?Glu?Val?His?Pro?Thr?Val?Phe?Tyr?Ile?Gly?Thr?Asn?Asn?Thr?His

275 280 285

Glu?Leu?Glu?Glu?Ile?Arg?Arg?Leu?Phe?Leu?Glu?Ala?Asp?Met?Pro?Leu

290 295 300

Pro?Ile?Ser?Gly?Glu?Tyr?Met?Gly?Arg?Ser?Ala?Phe?Asp?Leu?Ala?Glu

305 310 315 320

Lys?Tyr?Gly?Lys?Asp?Thr?Phe?Val?Phe?Leu?Lys?Phe?Met?Ser?Pro?Ala

325 330 335

Leu?Gln?Thr?Arg?Met?Phe?Ser?Phe?Lys?Thr?Trp?Ala?Asn?Gly?Leu?Phe

340 345 350

Ser?Lys?Ile?Pro?Gly?Ile?Gly?Pro?Thr?Phe?Ala?Asp?Thr?Val?Ser?Gln

355 360 365

Ala?Met?Phe?Ser?Val?Leu?Pro?Asn?Gln?Leu?Pro?Lys?Arg?Met?Met?Glu

370 375 380

Tyr?Arg?Asn?Arg?Phe?Glu?His?His?Leu?Leu?Leu?Thr?Val?Ser?Glu?Ser

385 390 395 400

Gln?Lys?Ala?Ala?Ser?Glu?Lys?Met?Leu?Lys?Glu?Phe?Phe?Ala?Glu?Pro

405 410 415

Glu?His?Thr?Gly?Glu?Phe?Phe?Ile?Cys?Thr?Ser?Asp?Glu?Glu?Lys?Ser

420 425 430

Ala?Ser?Leu?Asn?Arg?Phe?Gly?Ala?Ala?Ser?Ala?Ala?Thr?Arg?Tyr?Ala

435 440 445

Ala?Leu?Lys?Arg?Arg?His?Ile?Ala?Gly?Leu?Ile?Pro?Ile?Asp?Val?Ala

450 455 460

Leu?Arg?Arg?Asp?Asp?Trp?Asn?Trp?Leu?Glu?Val?Leu?Pro?Glu?Glu?Ile

465 470 475 480

Asp?Asp?Gln?Leu?Glu?Val?Lys?Ala?Tyr?Tyr?Gly?His?Phe?Phe?Cys?His

485 490 495

Val?Met?His?Gln?Asp?Tyr?Val?Ala?Lys?Gln?Gly?Val?Asp?Leu?Glu?Ala

500 505 510

Leu?His?Asp?Arg?Ile?Gln?His?Leu?Leu?Glu?Glu?Arg?Gly?Ala?Lys?Leu

515 520 525

Pro?Ala?Glu?His?Asn

530

<210>143

<211>1035

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1012)

<223>RXA00293

<400>143

agagattgtt?gattcggcac?caactttacc?cacgagggta?gaaatgaagc?attcaggatg?60

acaaaaccca?acctcacacc?aacaacctat?cctggagccc?atg?aaa?atc?ttt?gtt 115

Met?Lys?Ile?Phe?Val

1 5

ggt?ttt?ggc?gat?tat?cca?ctc?acc?acc?aag?gcc?ctt?aag?gag?gca?ggc 163

Gly?Phe?Gly?Asp?Tyr?Pro?Leu?Thr?Thr?Lys?Ala?Leu?Lys?Glu?Ala?Gly

10 15 20

gca?gaa?ata?gtg?gac?tcc?ctc?gaa?aaa?gcc?gag?ggg?ttt?gtc?ttc?act 211

Ala?Glu?Ile?Val?Asp?Ser?Leu?Glu?Lys?Ala?Glu?Gly?Phe?Val?Phe?Thr

25 30 35

caa?aca?cca?ggc?aca?gaa?ttt?ccc?cta?ctt?ccc?gac?gga?gtg?agg?tgg 259

Gln?Thr?Pro?Gly?Thr?Glu?Phe?Pro?Leu?Leu?Pro?Asp?Gly?Val?Arg?Trp

40 45 50

gtg?caa?ttt?ccc?aat?gcg?ggg?ctc?aac?gca?tat?ttc?aca?gct?ggg?cag 307

Val?Gln?Phe?Pro?Asn?Ala?Gly?Leu?Asn?Ala?Tyr?Phe?Thr?Ala?Gly?Gln

55 60 65

att?gat?gac?aaa?cgc?cgg?tgg?tca?aat?gca?tca?ggg?gtg?tat?ggc?caa 355

Ile?Asp?Asp?Lys?Arg?Arg?Trp?Ser?Asn?Ala?Ser?Gly?Val?Tyr?Gly?Gln

70 75 80 85

cag?gta?gcc?gaa?gca?gca?atg?gct?ctt?ttg?ctg?gga?ctg?att?cat?atg 403

Gln?Val?Ala?Glu?Ala?Ala?Met?Ala?Leu?Leu?Leu?Gly?Leu?Ile?His?Met

90 95 100

cac?ccc?acc?atg?gtg?cgt?gcc?gat?agt?tgg?gca?cca?agc?act?caa?ata 451

His?Pro?Thr?Met?Val?Arg?Ala?Asp?Ser?Trp?Ala?Pro?Ser?Thr?Gln?Ile

105 110 115

gat?cag?cag?acc?aga?tgg?ctt?gat?ggt?gca?aca?gtt?gcc?att?gtg?gga 499

Asp?Gln?Gln?Thr?Arg?Trp?Leu?Asp?Gly?Ala?Thr?Val?Ala?Ile?Val?Gly

120 125 130

gct?ggt?gga?atc?ggt?aaa?cat?ctg?gca?gcc?atg?ttg?aaa?cct?ttt?ggc 547

Ala?Gly?Gly?Ile?Gly?Lys?His?Leu?Ala?Ala?Met?Leu?Lys?Pro?Phe?Gly

135 140 145

gca?aag?tct?tta?gca?gta?agc?agg?acc?ggt?aca?ccc?acc?caa?gat?ttt 595

Ala?Lys?Ser?Leu?Ala?Val?Ser?Arg?Thr?Gly?Thr?Pro?Thr?Gln?Asp?Phe

150 155 160 165

gat?gca?acg?gaa?cct?ata?tcc?aac?ctg?cac?caa?gta?ctt?gcc?gac?gcc 643

Asp?Ala?Thr?Glu?Pro?Ile?Ser?Asn?Leu?His?Gln?Val?Leu?Ala?Asp?Ala

170 175 180

gac?cat?gtg?gtg?ttg?tgc?gta?ccg?ctt?acc?gca?gac?acc?tat?cat?ctg 691

Asp?His?Val?Val?Leu?Cys?Val?Pro?Leu?Thr?Ala?Asn?Thr?Tyr?His?Leu

185 190 195

atc?gga?aaa?gca?gag?ctt?aaa?gca?atg?cag?tcc?act?gca?att?ttg?atc 739

Ile?Gly?Lys?Ala?Glu?Leu?Lys?Ala?Met?Gln?Ser?Thr?Ala?Ile?Leu?Ile

200 205 210

aac?gtg?gct?cgc?gga?gaa?gta?gta?gat?aca?gaa?gca?tta?gtt?gac?gcc 787

Asn?Val?Ala?Arg?Gly?Glu?Val?Val?Asp?Thr?Glu?Ala?Leu?Val?Asp?Ala

215 220 225

tta?gat?gcc?caa?gaa?ata?tcc?ggg?gca?ggc?tta?gat?gtc?acc?gat?cct 835

Leu?Asp?Ala?Gln?Glu?Ile?Ser?Gly?Ala?Gly?Leu?Asp?Val?Thr?Asp?Pro

230 235 240 245

gaa?cca?ttg?ccg?gac?gat?cat?cca?ctg?tgg?ggg?cgc?agc?aat?gtg?atc 883

Glu?Pro?Leu?Pro?Asp?Asp?His?Pro?Leu?Trp?Gly?Arg?Ser?Asn?Val?Ile

250 255 260

att?acc?ccg?cac?gta?gcc?aac?acg?ttg?acc?tcg?atg?gat?cgc?atg?ctt 931

Ile?Thr?Pro?His?Val?Ala?Asn?Thr?Leu?Thr?Ser?Met?Asp?Arg?Met?Leu

265 270 275

gcc?cca?gtg?gtg?gca?gaa?aac?tac?cga?cgg?ttt?ctc?gct?gga?gaa?aag 979

Ala?Pro?Val?Val?Ala?Glu?Asn?Tyr?Arg?Arg?Phe?Leu?Ala?Gly?Glu?Lys

280 285 290

atg?ctg?acc?gag?gtg?gac?atc?cac?aaa?ggt?tac?tagagcagtg?gctttgaata 1032

Met?Leu?Thr?Glu?Val?Asp?Ile?His?Lys?Gly?Tyr

295 300

tag 1035

<210>144

<211>304

<212>PRT

＜213〉Corynebacterium glutamicum

<400>144

Met?Lys?Ile?Phe?Val?Gly?Phe?Gly?Asp?Tyr?Pro?Leu?Thr?Thr?Lys?Ala

1 5 10 15

Leu?Lys?Glu?Ala?Gly?Ala?Glu?Ile?Val?Asp?Ser?Leu?Glu?Lys?Ala?Glu

20 25 30

Gly?Phe?Val?Phe?Thr?Gln?Thr?Pro?Gly?Thr?Glu?Phe?Pro?Leu?Leu?Pro

35 40 45

Asp?Gly?Val?Arg?Trp?Val?Gln?Phe?Pro?Asn?Ala?Gly?Leu?Asn?Ala?Tyr

50 55 60

Phe?Thr?Ala?Gly?Gln?Ile?Asp?Asp?Lys?Arg?Arg?Trp?Ser?Asn?Ala?Ser

65 70 75 80

Gly?Val?Tyr?Gly?Gln?Gln?Val?Ala?Glu?Ala?Ala?Met?Ala?Leu?Leu?Leu

85 90 95

Gly?Leu?Ile?His?Met?His?Pro?Thr?Met?Val?Arg?Ala?Asp?Ser?Trp?Ala

100 105 110

Pro?Ser?Thr?Gln?Ile?Asp?Gln?Gln?Thr?Arg?Trp?Leu?Asp?Gly?Ala?Thr

115 120 125

Val?Ala?Ile?Val?Gly?Ala?Gly?Gly?Ile?Gly?Lys?His?Leu?Ala?Ala?Met

130 135 140

Leu?Lys?Pro?Phe?Gly?Ala?Lys?Ser?Leu?Ala?Val?Ser?Arg?Thr?Gly?Thr

145 150 155 160

Pro?Thr?Gln?Asp?Phe?Asp?Ala?Thr?Glu?Pro?Ile?Ser?Asn?Leu?His?Gln

165 170 175

Val?Leu?Ala?Asp?Ala?Asp?His?Val?Val?Leu?Cys?Val?Pro?Leu?Thr?Ala

180 185 190

Asp?Thr?Tyr?His?Leu?Ile?Gly?Lys?Ala?Glu?Leu?Lys?Ala?Met?Gln?Ser

195 200 205

Thr?Ala?Ile?Leu?Ile?Asn?Val?Ala?Arg?Gly?Glu?Val?Val?Asp?Thr?Glu

210 215 220

Ala?Leu?Val?Asp?Ala?Leu?Asp?Ala?Gln?Glu?Ile?Ser?Gly?Ala?Gly?Leu

225 230 235 240

Asp?Val?Thr?Asp?Pro?Glu?Pro?Leu?Pro?Asp?Asp?His?Pro?Leu?Trp?Gly

245 250 255

Arg?Ser?Asn?Val?Ile?Ile?Thr?Pro?His?Val?Ala?Asn?Thr?Leu?Thr?Ser

260 265 270

Met?Asp?Arg?Met?Leu?Ala?Pro?Val?Val?Ala?Glu?Asn?Tyr?Arg?Arg?Phe

275 280 285

Leu?Ala?Gly?Glu?Lys?Met?Leu?Thr?Glu?Val?Asp?Ile?His?Lys?Gly?Tyr

290 295 300

<210>145

<211>687

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(62)..(664)

<223>RXN01130

<400>145

agttcgtggc?ggatgctgtg?aacgtttccg?gtggtcgcgt?gggcgaagag?gttctgtgtg?60

g?atg?gat?ctg?gct?cgc?aag?ctt?ggt?ctt?ctt?gct?ggc?aag?ctt?gtc?gac?109

Met?Asp?Leu?Ala?Arg?Lys?Leu?Gly?Leu?Leu?Ala?Gly?Lys?Leu?Val?Asp

1 5 10 15

gcc?gcc?cca?gtc?tcc?att?gag?gtt?gag?gct?cga?ggc?gag?ctt?tct?tcc 157

Ala?Ala?Pro?Val?Ser?Ile?Glu?Val?Glu?Ala?Arg?Gly?Glu?Leu?Ser?Ser

20 25 30

gag?cag?gtc?aat?gca?ctt?ggt?ttg?tcc?gct?gtt?cgt?ggt?ttg?ttc?tcc 205

Glu?Gln?Val?Asn?Ala?Leu?Gly?Leu?Ser?Ala?Val?Arg?Gly?Leu?Phe?Ser

35 40 45

gga?att?atc?gaa?gag?tcc?gtt?act?ttc?gtc?aac?gct?cct?cgc?att?gct 253

Gly?Ile?Ile?Glu?Glu?Ser?Val?Thr?Phe?Val?Asn?Ala?Pro?Arg?Ile?Ala

50 55 60

gaa?gag?cgt?ggc?ctg?gac?atc?tcc?gtg?aag?acc?aac?tct?gag?tct?gtt 301

Glu?Glu?Arg?Gly?Leu?Asp?Ile?Ser?Val?Lys?Thr?Asn?Ser?Glu?Ser?Val

65 70 75 80

act?cac?cgt?tcc?gtc?ctg?cag?gtc?aag?gtc?att?act?ggc?agc?ggc?gcg 349

Thr?His?Arg?Ser?Val?Leu?Gln?Val?Lys?Val?Ile?Thr?Gly?Ser?Gly?Ala

85 90 95

agc?gca?act?gtt?gtt?ggt?gcc?ctg?act?ggt?ctt?gag?cgc?gtt?gag?aag 397

Ser?Ala?Thr?Val?Val?Gly?Ala?Leu?Thr?Gly?Leu?Glu?Arg?Val?Glu?Lys

100 105 110

atc?acc?cgc?atc?aat?ggc?cgt?ggc?ctg?gat?ctg?cgc?gca?gag?ggt?ctg 445

Ile?Thr?Arg?Ile?Asn?Gly?Arg?Gly?Leu?Asp?Leu?Arg?Ala?Glu?Gly?Leu

115 120 125

aac?ctc?ttc?ctg?cag?tac?act?gac?gct?cct?ggt?gca?ctg?ggt?acc?gtt 493

Asn?Leu?Phe?Leu?Gln?Tyr?Thr?Asp?Ala?Pro?Gly?Ala?Leu?Gly?Thr?Val

130 135 140

ggt?acc?aag?ctg?ggt?gct?gct?ggc?atc?aac?atc?gag?gct?gct?gcg?ttg 541

Gly?Thr?Lys?Leu?Gly?Ala?Ala?Gly?Ile?Asn?Ile?Glu?Ala?Ala?Ala?Leu

145 150 155 160

act?cag?gct?gag?aag?ggt?gac?ggc?gct?gtc?ctg?atc?ctg?cgt?gtt?gag 589

Thr?Gln?Ala?Glu?Lys?Gly?Asp?Gly?Ala?Val?Leu?Ile?Leu?Arg?Val?Glu

165 170 175

tcc?gct?gtc?tct?gaa?gag?ctg?gaa?gct?gaa?atc?aac?gct?gag?ttg?ggt 637

Ser?Ala?Val?Ser?Glu?Glu?Leu?Glu?Ala?Glu?Ile?Asn?Ala?Glu?Leu?Gly

180 185 190

gct?act?tcc?ttc?cag?gtt?gat?ctt?gac?taattagaga?tccatttgct?tga 687

Ala?Thr?Ser?Phe?Gln?Val?Asp?Leu?Asp

195 200

<210>146

<211>201

<212>PRT

＜213〉Corynebacterium glutamicum

<400>146

Met?Asp?Leu?Ala?Arg?Lys?Leu?Gly?Leu?Leu?Ala?Gly?Lys?Leu?Val?Asp

1 5 10 15

Ala?Ala?Pro?Val?Ser?Ile?Glu?Val?Glu?Ala?Arg?Gly?Glu?Leu?Ser?Ser

20 25 30

Glu?Gln?Val?Asn?Ala?Leu?Gly?Leu?Ser?Ala?Val?Arg?Gly?Leu?Phe?Ser

35 40 45

Gly?Ile?Ile?Glu?Glu?Ser?Val?Thr?Phe?Val?Asn?Ala?Pro?Arg?Ile?Ala

50 55 60

Glu?Glu?Arg?Gly?Leu?Asp?Ile?Ser?Val?Lys?Thr?Asn?Ser?Glu?Ser?Val

65 70 75 80

Thr?His?Arg?Ser?Val?Leu?Gln?Val?Lys?Val?Ile?Thr?Gly?Ser?Gly?Ala

85 90 95

Ser?Ala?Thr?Val?Val?Gly?Ala?Leu?Thr?Gly?Leu?Glu?Arg?Val?Glu?Lys

100 105 110

Ile?Thr?Arg?Ile?Asn?Gly?Arg?Gly?Leu?Asp?Leu?Arg?Ala?Glu?Gly?Leu

115 120 125

Asn?Leu?Phe?Leu?Gln?Tyr?Thr?Asp?Ala?Pro?Gly?Ala?Leu?Gly?Thr?Val

130 135 140

Gly?Thr?Lys?Leu?Gly?Ala?Ala?Gly?Ile?Asn?Ile?Glu?Ala?Ala?Ala?Leu

145 150 155 160

Thr?Gln?Ala?Glu?Lys?Gly?Asp?Gly?Ala?Val?Leu?Ile?Leu?Arg?Val?Glu

165 170 175

Ser?Ala?Val?Ser?Glu?Glu?Leu?Glu?Ala?Glu?Ile?Asn?Ala?Glu?Leu?Gly

180 185 190

Ala?Thr?Ser?Phe?Gln?Val?Asp?Leu?Asp

195 200

<210>147

<211>326

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(303)

<223>FRXA01130

<400>147

gtt?ggt?gcc?ctg?act?ggt?ctt?gag?cgc?gtt?gag?aag?atc?acc?cgc?atc 48

Val?Gly?Ala?Leu?Thr?Gly?Leu?Glu?Arg?Val?Glu?Lys?Ile?Thr?Arg?Ile

1 5 10 15

aat?ggc?cgt?ggc?ctg?gat?ctg?cgc?gca?gag?ggt?ctg?aac?ctc?ttc?ctg 96

Asn?Gly?Arg?Gly?Leu?Asp?Leu?Arg?Ala?Glu?Gly?Leu?Asn?Leu?Phe?Leu

20 25 30

cag?tac?act?gac?gct?cct?ggt?gca?ctg?ggt?acc?gtt?ggt?acc?aag?ctg 144

Gln?Tyr?Thr?Asp?Ala?Pro?Gly?Ala?Leu?Gly?Thr?Val?Gly?Thr?Lys?Leu

35 40 45

ggt?gct?gct?ggc?atc?aac?atc?gag?gct?gct?gcg?ttg?act?cag?gct?gag 192

Gly?Ala?Ala?Gly?Ile?Asn?Ile?Glu?Ala?Ala?Ala?Leu?Thr?Gln?Ala?Glu

50 55 60

aag?ggt?gac?ggc?gct?gtc?ctg?atc?ctg?cgt?gtt?gag?tcc?gct?gtc?tct 240

Lys?Gly?Asp?Gly?Ala?Val?Leu?Ile?Leu?Arg?Val?Glu?Ser?Ala?Val?Ser

65 70 75 80

gaa?gag?ctg?gaa?gct?gaa?atc?aac?gct?gag?ttg?ggt?gct?act?tcc?ttc 288

Glu?Glu?Leu?Glu?Ala?Glu?Ile?Asn?Ala?Glu?Leu?Gly?Ala?Thr?Ser?Phe

85 90 95

cag?gtt?gat?ctt?gac?taattagaga?tccatttgct?tga 326

Gln?Val?Asp?Leu?Asp

100

<210>148

<211>101

<212>PRT

＜213〉Corynebacterium glutamicum

<400>148

Val?Gly?Ala?Leu?Thr?Gly?Leu?Glu?Arg?Val?Glu?Lys?Ile?Thr?Arg?Ile

1 5 10 15

Asn?Gly?Arg?Gly?Leu?Asp?Leu?Arg?Ala?Glu?Gly?Leu?Asn?Leu?Phe?Leu

20 25 30

Gln?Tyr?Thr?Asp?Ala?Pro?Gly?Ala?Leu?Gly?Thr?Val?Gly?Thr?Lys?Leu

35 40 45

Gly?Ala?Ala?Gly?Ile?Asn?Ile?Glu?Ala?Ala?Ala?Leu?Thr?Gln?Ala?Glu

50 55 60

Lys?Gly?Asp?Gly?Ala?Val?Leu?Ile?Leu?Arg?Val?Glu?Ser?Ala?Val?Ser

65 70 75 80

Glu?Glu?Leu?Glu?Ala?Glu?Ile?Asn?Ala?Glu?Leu?Gly?Ala?Thr?Ser?Phe

85 90 95

Gln?Val?Asp?Leu?Asp

100

<210>149

<211>604

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(604)

<223>RXN03112

<400>149

gtgagcacgc?aatttctttg?ctgctgtcta?ctgctcgcca?gatcctgctg?ctgatgcgac?60

gctgcgtgag?ggcgagtgga?agcggtcttc?tttcaacggt?gtg?gaa?att?ttc?gga 115

Val?Glu?Ile?Phe?Gly

1 5

aaa?act?gtc?ggt?atc?gtc?ggt?ttt?ggc?cac?att?ggt?cag?ttg?ttt?gct 163

Lys?Thr?Val?Gly?Ile?Val?Gly?Phe?Gly?His?Ile?Gly?Gln?Leu?Phe?Ala

10 15 20

cag?cgt?ctt?gct?gcg?ttt?gag?acc?acc?att?gtt?gct?tac?gat?cct?tac 211

Gln?Arg?Leu?Ala?Ala?Phe?Glu?Thr?Thr?Ile?Val?Ala?Tyr?Asp?Pro?Tyr

25 30 35

gct?aac?cct?gct?cgt?gcg?gct?cag?ctg?aac?gtt?gag?ttg?gtt?gag?ttg 259

Ala?Asn?Pro?Ala?Arg?Ala?Ala?Gln?Leu?Asn?Val?Glu?Leu?Val?Glu?Leu

40 45 50

gat?gag?ctg?atg?agc?cgt?tct?gac?ttt?gtc?acc?att?cac?ctt?cct?aag 307

Asp?Glu?Leu?Met?Ser?Arg?Ser?Asp?Phe?Val?Thr?Ile?His?Leu?Pro?Lys

55 60 65

acc?aag?gaa?act?gct?ggc?atg?ttt?gat?gcg?cac?ctc?ctt?gct?aag?tcc 355

Thr?Lys?Glu?Thr?Ala?Gly?Met?Phe?Asp?Ala?His?Leu?Leu?Ala?Lys?Ser

70 75 80 85

aag?aag?ggc?cag?atc?atc?atc?aac?gct?gct?cgt?ggt?ggc?ctt?gtt?gat 403

Lys?Lys?Gly?Gln?Ile?Ile?Ile?Asn?Ala?Ala?Arg?Gly?Gly?Leu?Val?Asp

90 95 100

gag?cag?gct?ttg?gct?gat?gcg?att?gag?tcc?ggt?cac?att?cgt?ggc?gct 451

Glu?Gln?Ala?Leu?Ala?Asp?Ala?Ile?Glu?Ser?Gly?His?Ile?Arg?Gly?Ala

105 110 115

ggt?ttc?gat?gtg?tac?tcc?acc?gag?cct?tgc?act?gat?tct?cct?ttg?ttc 499

Gly?Phe?Asp?Val?Tyr?Ser?Thr?Glu?Pro?Cys?Thr?Asp?Ser?Pro?Leu?Phe

120 125 130

aag?ttg?cct?cag?gtt?gtt?gtg?act?cct?cac?ttg?ggt?gct?tct?act?gaa 547

Lys?Leu?Pro?Gln?Val?Val?Val?Thr?Pro?His?Leu?Gly?Ala?Ser?Thr?Glu

135 140 145

gag?gct?caa?gat?cgt?gcg?ggt?act?gac?att?gct?gat?tct?gtg?ctc?aag 595

Glu?Ala?Gln?Asp?Arg?Ala?Gly?Thr?Asp?Ile?Ala?Asp?Ser?Val?Leu?Lys

150 155 160 165

gcg?ctg?gct 604

Ala?Leu?Ala

<210>150

<211>168

<212>PRT

＜213〉Corynebacterium glutamicum

<400>150

Val?Glu?Ile?Phe?Gly?Lys?Thr?Val?Gly?Ile?Val?Gly?Phe?Gly?His?Ile

1 5 10 15

Gly?Gln?Leu?Phe?Ala?Gln?Arg?Leu?Ala?Ala?Phe?Glu?Thr?Thr?Ile?Val

20 25 30

Ala?Tyr?Asp?Pro?Tyr?Ala?Asn?Pro?Ala?Arg?Ala?Ala?Gln?Leu?Asn?Val

35 40 45

Glu?Leu?Val?Glu?Leu?Asp?Glu?Leu?Met?Ser?Arg?Ser?Asp?Phe?Val?Thr

50 55 60

Ile?His?Leu?Pro?Lys?Thr?Lys?Glu?Thr?Ala?Gly?Met?Phe?Asp?Ala?His

65 70 75 80

Leu?Leu?Ala?Lys?Ser?Lys?Lys?Gly?Gln?Ile?Ile?Ile?Asn?Ala?Ala?Arg

85 90 95

Gly?Gly?Leu?Val?Asp?Glu?Gln?Ala?Leu?Ala?Asp?Ala?Ile?Glu?Ser?Gly

100 105 110

His?Ile?Arg?Gly?Ala?Gly?Phe?Asp?Val?Tyr?Ser?Thr?Glu?Pro?Cys?Thr

115 120 125

Asp?Ser?Pro?Leu?Phe?Lys?Leu?Pro?Gln?Val?Val?Val?Thr?Pro?His?Leu

130 135 140

Gly?Ala?Ser?Thr?Glu?Glu?Ala?Gln?Asp?Arg?Ala?Gly?Thr?Asp?Ile?Ala

145 150 155 160

Asp?Ser?Val?Leu?Lys?Ala?Leu?Ala

165

<210>151

<21l>649

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(649)

<223>FRXA01133

<400>151

tgtttctagt?cgcacgccaa?aacccggcgt?ggacacgtct?gcagccgacg?cggtcgtgcc?60

tgttgtagac?ggacattcct?agtttttcca?ggagtaactt?gtg?agc?cag?aat?ggc 115

Val?Ser?Gln?Asn?Gly

1 5

cgt?ccg?gta?gtc?ctc?atc?gcc?gat?aag?ctt?gcg?cag?tcc?act?gtt?gac 163

Arg?Pro?Val?Val?Leu?Ile?Ala?Asp?Lys?Leu?Ala?Gln?Ser?Thr?Val?Asp

10 15 20

gcg?ctt?gga?gat?gca?gta?gaa?gtc?cgt?tgg?gtt?gac?gga?cct?aac?cgc 211

Ala?Leu?Gly?Asp?Ala?Val?Glu?Val?Arg?Trp?Val?Asp?Gly?Pro?Asn?Arg

25 30 35

cca?gaa?ctg?ctt?gat?gca?gtt?aag?gaa?gcg?gac?gca?ctg?ctc?gtg?cgt 259

Pro?Glu?Leu?Leu?Asp?Ala?Val?Lys?Glu?Ala?Asp?Ala?Leu?Leu?Val?Arg

40 45 50

tct?gct?acc?act?gtc?gat?gct?gaa?gtc?atc?gcc?gct?gcc?cct?aac?ttg 307

Ser?Ala?Thr?Thr?Val?Asp?Ala?Glu?Val?Ile?Ala?Ala?Ala?Pro?Asn?Leu

55 60 65

aag?atc?gtc?ggt?cgt?gcc?ggc?gtg?ggc?ttg?gac?aac?gtt?gac?atc?cct 355

Lys?Ile?Val?Gly?Arg?Ala?Gly?Val?Gly?Leu?Asp?Asn?Val?Asp?Ile?Pro

70 75 80 85

gct?gcc?act?gaa?gct?ggc?gtc?atg?gtt?gct?aac?gca?ccg?acc?tct?aat 403

Ala?Ala?Thr?Glu?Ala?Gly?Val?Met?Val?Ala?Asn?Ala?Pro?Thr?Ser?Asn

90 95 100

att?cac?tcc?gct?tgt?gag?cac?gca?att?tct?ttg?ctg?ctg?tct?act?gct 451

Ile?His?Ser?Ala?Cys?Glu?His?Ala?Ile?Ser?Leu?Leu?Leu?Ser?Thr?Ala

105 110 115

cgc?cag?atc?ctg?ctg?ctg?atg?cga?cgc?tgc?gtg?agg?gcg?agt?gga?agc 499

Arg?Gln?Ile?Leu?Leu?Leu?Met?Arg?Arg?Cys?Val?Arg?Ala?Ser?Gly?Ser

120 125 130

ggt?ctt?ctt?tca?acg?gtg?tgg?aaa?ttt?tcg?gaa?aaa?ctg?tcg?gta?tcg 547

Gly?Leu?Leu?Ser?Thr?Val?Trp?Lys?Phe?Ser?Glu?Lys?Leu?Ser?Val?Ser

135 140 145

tcg?gtt?ttg?gcc?aca?ttg?gtc?agt?tgt?ttg?ctc?agc?gtc?ttg?ctg?cgt 595

Ser?Val?Leu?Ala?Thr?Leu?Val?Ser?Cys?Leu?Leu?Ser?Val?Leu?Leu?Arg

150 155 160 165

ttg?aga?cca?cca?ttg?ttg?ctt?acg?atc?ctt?acg?cta?acc?ctg?ctt?cgt 643

Leu?Arg?Pro?Pro?Leu?Leu?Leu?Thr?Ile?Leu?Thr?Leu?Thr?Leu?Leu?Arg

170 175 180

gcg?ggt 649

Ala?Gly

<210>152

<211>183

<212>PRT

＜213〉Corynebacterium glutamicum

<400>152

Val?Ser?Gln?Asn?Gly?Arg?Pro?Val?Val?Leu?Ile?Ala?Asp?Lys?Leu?Ala

1 5 10 15

Gln?Ser?Thr?Val?Asp?Ala?Leu?Gly?Asp?Ala?Val?Glu?Val?Arg?Trp?Val

20 25 30

Asp?Gly?Pro?Asn?Arg?Pro?Glu?Leu?Leu?Asp?Ala?Val?Lys?Glu?Ala?Asp

35 40 45

Ala?Leu?Leu?Val?Arg?Ser?Ala?Thr?Thr?Val?Asp?Ala?Glu?Val?Ile?Ala

50 55 60

Ala?Ala?Pro?Asn?Leu?Lys?Ile?Val?Gly?Arg?Ala?Gly?Val?Gly?Leu?Asp

65 70 75 80

Asn?Val?Asp?Ile?Pro?Ala?Ala?Thr?Glu?Ala?Gly?Val?Met?Val?Ala?Asn

85 90 95

Ala?Pro?Thr?Ser?Asn?Ile?His?Ser?Ala?Cys?Glu?His?Ala?Ile?Ser?Leu

100 105 110

Leu?Leu?Ser?Thr?Ala?Arg?Gln?Ile?Leu?Leu?Leu?Met?Arg?Arg?Cys?Val

115 120 125

Arg?Ala?Ser?Gly?Ser?Gly?Leu?Leu?Ser?Thr?Val?Trp?Lys?Phe?Ser?Glu

130 135 140

Lys?Leu?Ser?Val?Ser?Ser?Val?Leu?Ala?Thr?Leu?Val?Ser?Cys?Leu?Leu

145 150 155 160

Ser?Val?Leu?Leu?Arg?Leu?Arg?Pro?Pro?Leu?Leu?Leu?Thr?Ile?Leu?Thr

165 170 175

Leu?Thr?Leu?Leu?Arg?Ala?Gly

180

<210>153

<211>1011

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(988)

<223>RXN00871

<400>153

gggaaaaggc?gatcaccagc?cgttggctcg?acccagcaac?ccacggtggc?attaacctcg?60

gtttcccaca?gaacgattaa?ttgaaggaga?gcacaggact?atg?cgt?tgg?ttc?cat 115

Met?Arg?Trp?Phe?His

1 5

aag?aag?ggc?gaa?ctg?gcc?cga?gat?ggt?tgg?caa?agc?gtt?gtc?gat?gcc 163

Lys?Lys?Gly?Glu?Leu?Ala?Arg?Asp?Gly?Trp?Gln?Ser?Val?Val?Asp?Ala

10 15 20

acc?acc?cca?ggt?tgg?gaa?tat?acc?ggc?atc?cgc?att?gcc?gaa?ctg?ggc 211

Thr?Thr?Pro?Gly?Trp?Glu?Tyr?Thr?Gly?Ile?Arg?Ile?Ala?Glu?Leu?Gly

25 30 35

agt?ggt?gaa?tcg?ctt?gaa?ctg?aat?gac?act?ggt?gtg?gaa?cgc?atc?ttc 259

Ser?Gly?Glu?Ser?Leu?Glu?Leu?Asn?Asp?Thr?Gly?Val?Glu?Ara?Ile?Phe

40 45 50

att?cca?ctt?cag?ggc?agc?ttc?gat?gtt?gcc?cac?cat?ggt?cag?gtg?acc 307

Ile?Pro?Leu?Gln?Gly?Ser?Phe?Asp?Val?Ala?His?His?Gly?Gln?Val?Thr

55 60 65

cat?ctt?cac?gga?aga?aag?tca?gtc?ttt?gat?gga?cca?acc?gat?gtg?ctc 355

His?Leu?His?Gly?Arg?Lys?Ser?Val?Phe?Asp?Gly?Pro?Thr?Asp?Val?Leu

70 75 80 85

tac?ctc?ccc?act?gga?caa?aca?gca?acg?ctc?agt?ggt?cag?gga?cga?gtc 403

Tyr?Leu?Pro?Thr?Gly?Gln?Thr?Ala?Thr?Leu?Ser?Gly?Gln?Gly?Arg?Val

90 95 100

gcc?gtg?gcg?gaa?gct?ccc?act?cag?gaa?ccc?aag?gag?tgg?aag?tac?atc 451

Ala?Val?Ala?Glu?Ala?Pro?Thr?Gln?Glu?Pro?Lys?Glu?Trp?Lys?Tyr?Ile

105 110 115

gct?cca?gca?gaa?act?cct?gtg?gag?ttg?cgt?gga?gct?ggc?cgc?tcg?agc 499

Ala?Pro?Ala?Glu?Thr?Pro?Val?Glu?Leu?Arg?Gly?Ala?Gly?Arg?Ser?Ser

120 125 130

cga?caa?gtc?cac?aac?ttt?ggc?acc?ccg?gaa?gct?ctc?gat?gct?gct?cga 547

Arg?Gln?Val?His?Asn?Phe?Gly?Thr?Pro?Glu?Ala?Leu?Asp?Ala?Ala?Arg

135 140 145

cta?atc?gtg?tgt?gaa?gta?atc?acc?cca?ggt?gaa?aac?tgg?agc?tct?tac 595

Leu?Ile?Val?Cys?Glu?Val?Ile?Thr?Pro?Gly?Glu?Asn?Trp?Ser?Ser?Tyr

150 155 160 165

cct?cca?cac?aag?cat?gat?gag?cac?atc?cca?gga?cac?gag?tcc?aag?ctg 643

Pro?Pro?His?Lys?His?Asp?Glu?His?Ile?Pro?Gly?His?Glu?Ser?Lys?Leu

170 175 180

gag?gaa?atc?tac?tac?ttc?gaa?agc?gcc?cca?tcg?cga?gtt?ggt?ggc?agg 691

Glu?Glu?Ile?Tyr?Tyr?Phe?Glu?Ser?Ala?Pro?Ser?Arg?Val?Gly?Gly?Arg

185 190 195

gcc?gaa?gca?gca?gaa?gga?gct?ttc?gga?atg?ttt?tcc?acc?tac?tcc?tca 739

Ala?Glu?Ala?Ala?Glu?Gly?Ala?Phe?Gly?Met?Phe?Ser?Thr?Tyr?Ser?Ser

200 205 210

cca?gcg?ggg?gag?atc?gat?atc?aac?gcc?atg?gtg?tac?agc?ggc?gat?atc 787

Pro?Ala?Gly?Glu?Ile?Asp?Ile?Asn?Ala?Met?Val?Tyr?Ser?Gly?Asp?Ile

215 220 225

gcg?cta?gtt?cct?ttc?gga?tac?cac?ggc?cct?gcc?gtg?gca?gca?cct?ggc 835

Ala?Leu?Val?Pro?Phe?Gly?Tyr?His?Gly?Pro?Ala?Val?Ala?Ala?Pro?Gly

230 235 240 245

tat?gac?ttg?tac?tac?ctc?aac?gtc?atg?gca?gga?cct?gat?ccg?gag?aga 883

Tyr?Asp?Leu?Tyr?Tyr?Leu?Asn?Val?Met?Ala?Gly?Pro?Asp?Pro?Glu?Arg

250 255 260

atc?tgg?ctg?att?aac?gat?gac?cca?gcg?cac?gcc?tgg?gtt?cga?gat?aca 931

Ile?Trp?Leu?Ile?Asn?Asp?Asp?Pro?Ala?His?Ala?Trp?Val?Arg?Asp?Thr

265 270 275

tgg?acc?ggg?caa?gca?ttt?gat?gat?cgc?ttg?cca?tat?gag?aac?gca?aac 979

Trp?Thr?Gly?Gln?Ala?Phe?Asp?Asp?Arg?Leu?Pro?Tyr?Glu?Asn?Ala?Asn

280 285 290

aag?gag?gga?taaaatttca?tggctgaaac?gaa 1011

Lys?Glu?Gly

295

<210>154

<211>296

<212>PRT

＜213〉Corynebacterium glutamicum

<400>154

Met?Arg?Trp?Phe?His?Lys?Lys?Gly?Glu?Leu?Ala?Arg?Asp?Gly?Trp?Gln

1 5 10 15

Ser?Val?Val?Asp?Ala?Thr?Thr?Pro?Gly?Trp?Glu?Tyr?Thr?Gly?Ile?Arg

20 25 30

Ile?Ala?Glu?Leu?Gly?Ser?Gly?Glu?Ser?Leu?Glu?Leu?Asn?Asp?Thr?Gly

35 40 45

Val?Glu?Arg?Ile?Phe?Ile?Pro?Leu?Gln?Gly?Ser?Phe?Asp?Val?Ala?His

50 55 60

His?Gly?Gln?Val?Thr?His?Leu?His?Gly?Arg?Lys?Ser?Val?Phe?Asp?Gly

65 70 75 80

Pro?Thr?Asp?Val?Leu?Tyr?Leu?Pro?Thr?Gly?Gln?Thr?Ala?Thr?Leu?Ser

85 90 95

Gly?Gln?Gly?Arg?Val?Ala?Val?Ala?Glu?Ala?Pro?Thr?Gln?Glu?Pro?Lys

100 105 110

Glu?Trp?Lys?Tyr?Ile?Ala?Pro?Ala?Glu?Thr?Pro?Val?Glu?Leu?Arg?Gly

115 120 125

Ala?Gly?Arg?Ser?Ser?Arg?Gln?Val?His?Asn?Phe?Gly?Thr?Pro?Glu?Ala

130 135 140

Leu?Asp?Ala?Ala?Arg?Leu?Ile?Val?Cys?Glu?Val?Ile?Thr?Pro?Gly?Glu

145 150 155 160

Asn?Trp?Ser?Ser?Tyr?Pro?Pro?His?Lys?His?Asp?Glu?His?Ile?Pro?Gly

165 170 175

His?Glu?Ser?Lys?Leu?Glu?Glu?Ile?Tyr?Tyr?Phe?Glu?Ser?Ala?Pro?Ser

180 185 190

Arg?Val?Gly?Gly?Arg?Ala?Glu?Ala?Ala?Glu?Gly?Ala?Phe?Gly?Met?Phe

195 200 205

Ser?Thr?Tyr?Ser?Ser?Pro?Ala?Gly?Glu?Ile?Asp?Ile?Asn?Ala?Met?Val

210 215 220

Tyr?Ser?Gly?Asp?Ile?Ala?Leu?Val?Pro?Phe?Gly?Tyr?His?Gly?Pro?Ala

225 230 235 240

Val?Ala?Ala?Pro?Gly?Tyr?Asp?Leu?Tyr?Tyr?Leu?Asn?Val?Met?Ala?Gly

245 250 255

Pro?Asp?Pro?Glu?Arg?Ile?Trp?Leu?Ile?Asn?Asp?Asp?Pro?Ala?His?Ala

260 265 270

Trp?Val?Arg?Asp?Thr?Trp?Thr?Gly?Gln?Ala?Phe?Asp?Asp?Arg?Leu?Pro

275 280 285

Tyr?Glu?Asn?Ala?Asn?Lys?Glu?Gly

290 295

<210>155

<211>964

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(964)

<223>FRXA00871

<400>155

gggaaaaggc?gatcaccagc?cgttggctcg?acccagcaac?ccacggtggc?attaacctcg?60

gtttcccaca?gaacgattaa?ttgaaggaga?gcacaggact?atg?cgt?tgg?ttc?cat 115

Met?Arg?Trp?Phe?His

1 5

aag?aag?ggc?gaa?ctg?gcc?cga?gat?ggt?tgg?caa?agc?gtt?gtc?gat?gcc 163

Lys?Lys?Gly?Glu?Leu?Ala?Arg?Asp?Gly?Trp?Gln?Ser?Val?Val?Asp?Ala

10 15 20

acc?acc?cca?ggt?tgg?gaa?tat?acc?ggc?atc?cgc?att?gcc?gaa?ctg?ggc 211

Thr?Thr?Pro?Gly?Trp?Glu?Tyr?Thr?Gly?Ile?Arg?Ile?Ala?Glu?Leu?Gly

25 30 35

agt?ggt?gaa?tcg?ctt?gaa?ctg?aat?gac?act?ggt?gtg?gaa?cgc?atc?ttc 259

Ser?Gly?Glu?Ser?Leu?Glu?Leu?Asn?Asp?Thr?Gly?Val?Glu?Arg?Ile?Phe

40 45 50

att?cca?ctt?cag?ggc?agc?ttc?gat?gtt?gcc?cac?cat?ggt?cag?gtg?acc 307

Ile?Pro?Leu?Gln?Gly?Ser?Phe?Asp?Val?Ala?His?His?Gly?Gln?Val?Thr

55 60 65

cat?ctt?cac?gga?aga?aag?tca?gtc?ttt?gat?gga?cca?acc?gat?gtg?ctc 355

His?Leu?His?Gly?Arg?Lys?Ser?Val?Phe?Asp?Gly?Pro?Thr?Asp?Val?Leu

70 75 80 85

tac?ctc?ccc?act?gga?caa?aca?gca?acg?ctc?agt?ggt?cag?gga?cga?gtc 403

Tyr?Leu?Pro?Thr?Gly?Gln?Thr?Ala?Thr?Leu?Ser?Gly?Gln?Gly?Arg?Val

90 95 100

gcc?gtg?gcg?gaa?gct?ccc?act?cag?gaa?ccc?aag?gag?tgg?aag?tac?atc 451

Ala?Val?Ala?Glu?Ala?Pro?Thr?Gln?Glu?Pro?Lys?Glu?Trp?Lys?Tyr?Ile

105 110 115

gct?cca?gca?gaa?act?cct?gtg?gag?ttg?cgt?gga?gct?ggc?cgc?tcg?agc 499

Ala?Pro?Ala?Glu?Thr?Pro?Val?Glu?Leu?Arg?Gly?Ala?Gly?Arg?Ser?Ser

120 125 130

cga?caa?gtc?cac?aac?ttt?ggc?acc?ccg?gaa?gct?ctc?gat?gct?gct?cga 547

Arg?Gln?Val?His?Asn?Phe?Gly?Thr?Pro?Glu?Ala?Leu?Asp?Ala?Ala?Arg

135 140 145

cta?atc?gtg?tgt?gaa?gta?atc?acc?cca?ggt?gaa?aac?tgg?agc?tct?tac 595

Leu?Ile?Val?Cys?Glu?Val?Ile?Thr?Pro?Gly?Glu?Asn?Trp?Ser?Ser?Tyr

150 155 160 165

cct?cca?cac?aag?cat?gat?gag?cac?atc?cca?gga?cac?gag?tcc?aag?ctg 643

Pro?Pro?His?Lys?His?Asp?Glu?His?Ile?Pro?Gly?His?Glu?Ser?Lys?Leu

170 175 180

gag?gaa?atc?tac?tac?ttc?gaa?agc?gcc?cca?tcg?cga?gtt?ggt?ggc?agg 691

Glu?Glu?Ile?Tyr?Tyr?Phe?Glu?Ser?Ala?Pro?Ser?Arg?Val?Gly?Gly?Arg

185 190 195

gcc?gaa?gca?gca?gaa?gga?gct?ttc?gga?atg?ttt?tcc?acc?tac?tcc?tca 739

Ala?Glu?Ala?Ala?Glu?Gly?Ala?Phe?Gly?Met?Phe?Ser?Thr?Tyr?Ser?Ser

200 205 210

cca?gcg?ggg?gag?atc?gat?atc?aac?gcc?atg?gtg?tac?agc?ggc?gat?atc 787

Pro?Ala?Gly?Glu?Ile?Asp?Ile?Asn?Ala?Met?Val?Tyr?Ser?Gly?Asp?Ile

215 220 225

gcg?cta?gtt?cct?ttc?gga?tac?cac?ggc?cct?gcc?gtg?gca?gca?cct?ggc 835

Ala?Leu?Val?Pro?Phe?Gly?Tyr?His?Gly?Pro?Ala?Val?Ala?Ala?Pro?Gly

230 235 240 245

tat?gac?ttg?tac?tac?ctc?aac?gtc?atg?gca?gga?cct?gat?ccg?gag?aga 883

Tyr?Asp?Leu?Tyr?Tyr?Leu?Asn?Val?Met?Ala?Gly?Pro?Asp?Pro?Glu?Arg

250 255 260

atc?tgg?ctg?att?aac?gat?gac?cca?gcg?cac?gcc?tgg?gtt?cga?gat?aca 931

Ile?Trp?Leu?Ile?Asn?Asp?Asp?Pro?Ala?His?Ala?Trp?Val?Arg?Asp?Thr

265 270 275

tgg?acc?ggg?caa?gca?ttt?gat?gat?cgc?ttg?cca 964

Trp?Thr?Gly?Gln?Ala?Phe?Asp?Asp?Arg?Leu?Pro

280 285

<210>156

<211>288

<212>PRT

＜213〉Corynebacterium glutamicum

<400>156

Met?Arg?Trp?Phe?His?Lys?Lys?Gly?Glu?Leu?Ala?Arg?Asp?Gly?Trp?Gln

1 5 10 15

Ser?Val?Val?Asp?Ala?Thr?Thr?Pro?Gly?Trp?Glu?Tyr?Thr?Gly?Ile?Arg

20 25 30

Ile?Ala?Glu?Leu?Gly?Ser?Gly?Glu?Ser?Leu?Glu?Leu?Asn?Asp?Thr?Gly

35 40 45

Val?Glu?Arg?Ile?Phe?Ile?Pro?Leu?Gln?Gly?Ser?Phe?Asp?Val?Ala?His

50 55 60

His?Gly?Gln?Val?Thr?His?Leu?His?Gly?Arg?Lys?Ser?Val?Phe?Asp?Gly

65 70 75 80

Pro?Thr?Asp?Val?Leu?Tyr?Leu?Pro?Thr?Gly?Gln?Thr?Ala?Thr?Leu?Ser

85 90 95

Gly?Gln?Gly?Arg?Val?Ala?Val?Ala?Glu?Ala?Pro?Thr?Gln?Glu?Pro?Lys

100 105 110

Glu?Trp?Lys?Tyr?Ile?Ala?Pro?Ala?Glu?Thr?Pro?Val?Glu?Leu?Arg?Gly

115 120 125

Ala?Gly?Arg?Ser?Ser?Arg?Gln?Val?His?Asn?Phe?Gly?Thr?Pro?Glu?Ala

130 135 140

Leu?Asp?Ala?Ala?Arg?Leu?Ile?Val?Cys?Glu?Val?Ile?Thr?Pro?Gly?Glu

145 150 155 160

Asn?Trp?Ser?Ser?Tyr?Pro?Pro?His?Lys?His?Asp?Glu?His?Ile?Pro?Gly

165 170 175

His?Glu?Ser?Lys?Leu?Glu?Glu?Ile?Tyr?Tyr?Phe?Glu?Ser?Ala?Pro?Ser

180 185 190

Arg?Val?Gly?Gly?Arg?Ala?Glu?Ala?Ala?Glu?Gly?Ala?Phe?Gly?Met?Phe

195 200 205

Ser?Thr?Tyr?Ser?Ser?Pro?Ala?Gly?Glu?Ile?Asp?Ile?Asn?Ala?Met?Val

210 215 220

Tyr?Ser?Gly?Asp?Ile?Ala?Leu?Val?Pro?Phe?Gly?Tyr?His?Gly?Pro?Ala

225 230 235 240

Val?Ala?Ala?Pro?Gly?Tyr?Asp?Leu?Tyr?Tyr?Leu?Asn?Val?Met?Ala?Gly

245 250 255

Pro?Asp?Pro?Glu?Arg?Ile?Trp?Leu?Ile?Asn?Asp?Asp?Pro?Ala?His?Ala

260 265 270

Trp?Val?Arg?Asp?Thr?Trp?Thr?Gly?Gln?Ala?Phe?Asp?Asp?Arg?Leu?Pro

275 280 285

<210>157

<211>373

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(373)

<223>RXN02829

<400>157

tttttcgttt?aatctcatat?ttaaacacgt?tccttttaat?tggttttata?aattgataaa?60

ctgaattcgt?cagttaaagt?gtatcgaaag?gagactggac?atg?caa?aaa?aat?att 115

Met?Gln?Lys?Asn?Ile

1 5

cta?aaa?agt?ggc?atc?gaa?att?tct?gaa?ctt?ggg?tta?ggt?tgc?atg?agt 163

Leu?Lys?Ser?Gly?Ile?Glu?Ile?Ser?Glu?Leu?Gly?Leu?Gly?Cys?Met?Ser

10 15 20

tta?ggc?aca?gat?tat?aaa?aaa?gcg?caa?cca?att?att?gaa?agt?gca?att 211

Leu?Gly?Thr?Asp?Tyr?Lys?Lys?Ala?Gln?Pro?Ile?Ile?Glu?Ser?Ala?Ile

25 30 35

gat?aat?ggt?att?acg?tat?ttt?gat?act?gca?gat?att?tac?gat?caa?gga 259

Asp?Asn?Gly?Ile?Thr?Tyr?Phe?Asp?Thr?Ala?Asp?Ile?Tyr?Asp?Gln?Gly

40 45 50

gtt?aat?gaa?gaa?att?gtt?ggt?aaa?gcc?tta?aaa?aaa?tat?caa?aat?cgt 307

Val?Asn?Glu?Glu?Ile?Val?Gly?Lys?Ala?Leu?Lys?Lys?Tyr?Gln?Asn?Arg

55 60 65

gat?gac?atc?gtt?atc?gga?act?aaa?gtt?gga?aat?cga?tta?act?gac?gat 355

Asp?Asp?Ile?Val?Ile?Gly?Thr?Lys?Val?Gly?Asn?Arg?Leu?Thr?Asp?Asp

70 75 80 85

gga?cat?atg?acg?tgg?gat 373

Gly?His?Met?Thr?Trp?Asp

90

<210>158

<211>91

<212>PRT

＜213〉Corynebacterium glutamicum

<400>158

Met?Gln?Lys?Asn?Ile?Leu?Lys?Ser?Gly?Ile?Glu?Ile?Ser?Glu?Leu?Gly

1 5 10 15

Leu?Gly?Cys?Met?Ser?Leu?Gly?Thr?Asp?Tyr?Lys?Lys?Ala?Gln?Pro?Ile

20 25 30

Ile?Glu?Ser?Ala?Ile?Asp?Asn?Gly?Ile?Thr?Tyr?Phe?Asp?Thr?Ala?Asp

35 40 45

Ile?Tyr?Asp?Gln?Gly?Val?Asn?Glu?Glu?Ile?Val?Gly?Lys?Ala?Leu?Lys

50 55 60

Lys?Tyr?Gln?Asn?Arg?Asp?Asp?Ile?Val?Ile?Gly?Thr?Lys?Val?Gly?Asn

65 70 75 80

Arg?Leu?Thr?Asp?Asp?Gly?His?Met?Thr?Trp?Asp

85 90

<210>159

<211>376

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(376)

<223>FRXA02829

<400>159

tttttcgttt?aatctcatat?ttaaacacgt?tccttttaat?tggttttata?aattgataaa?60

ctgaattcgt?cagttaaagt?gtatcgaaag?gagactggac?atg?caa?aaa?aat?att 115

Met?Gln?Lys?Asn?Ile

1 5

cta?aaa?agt?ggc?atc?gaa?att?tct?gaa?ctt?ggg?tta?ggt?tgc?atg?agt 163

Leu?Lys?Ser?Gly?Ile?Glu?Ile?Ser?Glu?Leu?Gly?Leu?Gly?Cys?Met?Ser

10 15 20

tta?ggc?aca?gat?tat?aaa?aaa?gcg?caa?cca?att?att?gaa?agt?gca?att 211

Leu?Gly?Thr?Asp?Tyr?Lys?Lys?Ala?Gln?Pro?Ile?Ile?Glu?Ser?Ala?Ile

25 30 35

gat?aat?ggt?att?acg?tat?ttt?gat?act?gca?gat?att?tac?gat?caa?gga 259

Asp?Asn?Gly?Ile?Thr?Tyr?Phe?Asp?Thr?Ala?Asp?Ile?Tyr?Asp?Gln?Gly

40 45 50

gtt?aat?gaa?gaa?att?gtt?ggt?aaa?gcc?tta?aaa?aaa?tat?caa?aat?cgt 307

Val?Asn?Glu?Glu?Ile?Val?Gly?Lys?Ala?Leu?Lys?Lys?Tyr?Gln?Asn?Arg

55 60 65

gat?gac?atc?gtt?atc?gga?act?aaa?gtt?gga?aat?cga?tta?act?gac?gat 355

Asp?Asp?Ile?Val?Ile?Gly?Thr?Lys?Val?Gly?Asn?Arg?Leu?Thr?Asp?Asp

70 75 80 85

gga?cat?atg?acg?tgg?gga?tcc 376

Gly?His?Met?Thr?Trp?Gly?Ser

90

<210>160

<211>92

<212>PRT

＜213〉Corynebacterium glutamicum

<400>160

Met?Gln?Lys?Asn?Ile?Leu?Lys?Ser?Gly?Ile?Glu?Ile?Ser?Glu?Leu?Gly

1 5 10 15

Leu?Gly?Cys?Met?Ser?Leu?Gly?Thr?Asp?Tyr?Lys?Lys?Ala?Gln?Pro?Ile

20 25 30

Ile?Glu?Ser?Ala?Ile?Asp?Asn?Gly?Ile?Thr?Tyr?Phe?Asp?Thr?Ala?Asp

35 40 45

Ile?Tyr?Asp?Gln?Gly?Val?Asn?Glu?Glu?Ile?Val?Gly?Lys?Ala?Leu?Lys

50 55 60

Lys?Tyr?Gln?Asn?Arg?Asp?Asp?Ile?Val?Ile?Gly?Thr?Lys?Val?Gly?Asn

65 70 75 80

Arg?Leu?Thr?Asp?Asp?Gly?His?Met?Thr?Trp?Gly?Ser

85 90

<210>161

<211>948

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(925)

<223>RXN01468

<400>161

tgccaaggat?ttgaccaccg?tgcaggattt?gattgacttt?attaacacca?ataaggctga?60

ttagcgggaa?aatttcgccc?aaaacaggga?caatggtgtt?atg?aca?gtg?aac?att 115

Met?Thr?Val?Asn?Ile

1 5

tca?tat?ctg?acc?gac?atg?gac?ggc?gtc?ctc?atc?aaa?gag?ggc?gag?ata 163

Ser?Tyr?Leu?Thr?Asp?Met?Asp?Gly?Val?Leu?Ile?Lys?Glu?Gly?Glu?Ile

10 15 20

att?ccg?ggt?gca?gat?cgt?ttt?ctt?cag?tct?ctc?acc?gat?aac?aat?gtg 211

Ile?Pro?Gly?Ala?Asp?Arg?Phe?Leu?Gln?Ser?Leu?Thr?Asp?Asn?Asn?Val

25 30 35

gag?ttt?atg?gtt?ttg?acc?aac?aac?tcc?att?ttc?acc?ccg?agg?gat?ctt 259

Glu?Phe?Met?Val?Leu?Thr?Asn?Asn?Ser?Ile?Phe?Thr?Pro?Arg?Asp?Leu

40 45 50

tct?gca?cgt?ctt?aag?act?tcc?ggt?ttg?gat?atc?ccg?ccg?gag?cgt?att 307

Ser?Ala?Arg?Leu?Lys?Thr?Ser?Gly?Leu?Asp?Ile?Pro?Pro?Glu?Arg?Ile

55 60 65

tgg?act?tct?gca?acc?gcc?act?gct?cac?ttc?ctg?aaa?tcc?cag?gtc?aag 355

Trp?Thr?Ser?Ala?Thr?Ala?Thr?Ala?His?Phe?Leu?Lys?Ser?Gln?Val?Lys

70 75 80 85

gag?ggc?aca?gcc?tat?gtt?gtt?ggc?gag?tcc?ggt?ctg?acc?act?gcg?ttg 403

Glu?Gly?Thr?Ala?Tyr?Val?Val?Gly?Glu?Ser?Gly?Leu?Thr?Thr?Ala?Leu

90 95 100

cat?acc?gcg?ggt?tgg?att?ttg?acg?gat?gca?aat?cct?gag?ttt?gtt?gtc 451

His?Thr?Ala?Gly?Trp?Ile?Leu?Thr?Asp?Ala?Asn?Pro?Glu?Phe?Val?Val

105 110 115

ctg?ggc?gaa?acc?cgc?aca?tat?tcc?ttc?gag?gca?atc?act?act?gcg?ata 499

Leu?Gly?Glu?Thr?Arg?Thr?Tyr?Ser?Phe?Glu?Ala?Ile?Thr?Thr?Ala?Ile

120 125 130

aat?ctg?att?ttg?ggt?ggc?gct?cgc?ttt?att?tgc?acc?aac?ccg?gat?gtc 547

Asn?Leu?Ile?Leu?Gly?Gly?Ala?Arg?Phe?Ile?Cys?Thr?Asn?Pro?Asp?Val

135 140 145

act?gga?cct?tca?cca?agt?ggc?att?ttg?cct?gct?act?ggc?tct?gtc?gcc 595

Thr?Gly?Pro?Ser?Pro?Ser?Gly?Ile?Leu?Pro?Ala?Thr?Gly?Ser?Val?Ala

150 155 160 165

gca?ctt?att?acc?gca?gct?act?ggc?gct?gag?cct?tat?tac?atc?ggc?aag 643

Ala?Leu?Ile?Thr?Ala?Ala?Thr?Gly?Ala?Glu?Pro?Tyr?Tyr?Ile?Gly?Lys

170 175 180

cca?aac?cct?gtg?atg?atg?cgc?agt?gcg?ctg?aac?acc?atc?ggg?gcg?cat 691

Pro?Asn?Pro?Val?Met?Met?Arg?Ser?Ala?Leu?Asn?Thr?Ile?Gly?Ala?His

185 190 195

tcc?gag?cac?act?gtc?atg?atc?ggc?gac?cgc?atg?gac?acc?gac?gtg?aaa 739

Ser?Glu?His?Thr?Val?Met?Ile?Gly?Asp?Arg?Met?Asp?Thr?Asp?Val?Lys

200 205 210

tct?ggt?ttg?gaa?gcc?ggc?ctg?agc?acc?gtg?ctg?gtt?cga?agc?gga?att 787

Ser?Gly?Leu?Glu?Ala?Gly?Leu?Ser?Thr?Val?Leu?Val?Arg?Ser?Gly?Ile

215 220 225

tcc?gac?gac?gcc?gag?atc?cgc?cgc?tac?ccc?ttc?cgc?cca?act?cac?gtg 835

Ser?Asp?Asp?Ala?Glu?Ile?Arg?Arg?Tyr?Pro?Phe?Arg?Pro?Thr?His?Val

230 235 240 245

atc?aat?tcc?atc?gcc?gat?ctt?gcc?gat?tgc?tgg?gac?gat?cct?ttc?ggt 883

Ile?Asn?Ser?Ile?Ala?Asp?Leu?Ala?Asp?Cys?Trp?Asp?Asp?Pro?Phe?Gly

250 255 260

gac?ggt?gca?ttt?cac?gta?cca?gat?gag?cag?cag?ttc?act?gac 925

Asp?Gly?Ala?Phe?His?Val?Pro?Asp?Glu?Gln?Gln?Phe?Thr?Asp

265 270 275

tagtattctg?taggtcatgg?cat 948

<210>162

<211>275

<212>PRT

＜213〉Corynebacterium glutamicum

<400>162

Met?Thr?Val?Asn?Ile?Ser?Tyr?Leu?Thr?Asp?Met?Asp?Gly?Val?Leu?Ile

1 5 10 15

Lys?Glu?Gly?Glu?Ile?Ile?Pro?Gly?Ala?Asp?Arg?Phe?Leu?Gln?Ser?Leu

20 25 30

Thr?Asp?Asn?Asn?Val?Glu?Phe?Met?Val?Leu?Thr?Asn?Asn?Ser?Ile?Phe

35 40 45

Thr?Pro?Arg?Asp?Leu?Ser?Ala?Arg?Leu?Lys?Thr?Ser?Gly?Leu?Asp?Ile

50 55 60

Pro?Pro?Glu?Arg?Ile?Trp?Thr?Ser?Ala?Thr?Ala?Thr?Ala?His?Phe?Leu

65 70 75 80

Lys?Ser?Gln?Val?Lys?Glu?Gly?Thr?Ala?Tyr?Val?Val?Gly?Glu?Ser?Gly

85 90 95

Leu?Thr?Thr?Ala?Leu?His?Thr?Ala?Gly?Trp?Ile?Leu?Thr?Asp?Ala?Asn

100 105 110

Pro?Glu?Phe?Val?Val?Leu?Gly?Glu?Thr?Arg?Thr?Tyr?Ser?Phe?Glu?Ala

115 120 125

Ile?Thr?Thr?Ala?Ile?Asn?Leu?Ile?Leu?Gly?Gly?Ala?Arg?Phe?Ile?Cys

130 135 140

Thr?Asn?Pro?Asp?Val?Thr?Gly?Pro?Ser?Pro?Ser?Gly?Ile?Leu?Pro?Ala

145 150 155 160

Thr?Gly?Ser?Val?Ala?Ala?Leu?Ile?Thr?Ala?Ala?Thr?Gly?Ala?Glu?Pro

165 170 175

Tyr?Tyr?Ile?Gly?Lys?Pro?Asn?Pro?Val?Met?Met?Arg?Ser?Ala?Leu?Asn

180 185 190

Thr?Ile?Gly?Ala?His?Ser?Glu?His?Thr?Val?Met?Ile?Gly?Asp?Arg?Met

195 200 205

Asp?Thr?Asp?Val?Lys?Ser?Gly?Leu?Glu?Ala?Gly?Leu?Ser?Thr?Val?Leu

210 215 220

Val?Arg?Ser?Gly?Ile?Ser?Asp?Asp?Ala?Glu?Ile?Arg?Arg?Tyr?Pro?Phe

225 230 235 240

Arg?Pro?Thr?His?Val?Ile?Asn?Ser?Ile?Ala?Asp?Leu?Ala?Asp?Cys?Trp

245 250 255

Asp?Asp?Pro?Phe?Gly?Asp?Gly?Ala?Phe?His?Val?Pro?Asp?Glu?Gln?Gln

260 265 270

Phe?Thr?Asp

275

<210>163

<211>948

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(925)

<223>FRXA01468

<400>163

tgccaaggat?ttgaccaccg?tgcaggattt?gattgacttt?attaacacca?ataaggctga?60

ttagcgggaa?aatttcgccc?aaaacaggga?caatggtgtt?atg?aca?gtg?aac?att 115

Met?Thr?Val?Asn?Ile

1 5

tca?tat?ctg?acc?gac?atg?gac?ggc?gtc?ctc?atc?aaa?gag?ggc?gag?ata 163

Ser?Tyr?Leu?Thr?Asp?Met?Asp?Gly?Val?Leu?Ile?Lys?Glu?Gly?Glu?Ile

10 15 20

att?ccg?ggt?gca?gat?cgt?ttt?ctt?cag?tct?ctc?acc?gat?aac?aat?gtg 211

Ile?Pro?Gly?Ala?Asp?Arg?Phe?Leu?Gln?Ser?Leu?Thr?Asp?Asn?Asn?Val

25 30 35

gag?ttt?atg?gtt?ttg?acc?aac?aac?tcc?att?ttc?acc?ccg?agg?gat?ctt 259

Glu?Phe?Met?Val?Leu?Thr?Asn?Asn?Ser?Ile?Phe?Thr?Pro?Arg?Asp?Leu

40 45 50

tct?gca?cgt?ctt?aag?act?tcc?ggt?ttg?gat?atc?ccg?ccg?gag?cgt?att 307

Ser?Ala?Arg?Leu?Lys?Thr?Ser?Gly?Leu?Asp?Ile?Pro?Pro?Glu?Arg?Ile

55 60 65

tgg?act?tct?gca?acc?gcc?act?gct?cac?ttc?ctg?aaa?tcc?cag?gtc?aag 355

Trp?Thr?Ser?Ala?Thr?Ala?Thr?Ala?His?Phe?Leu?Lys?Ser?Gln?Val?Lys

70 75 80 85

gag?ggc?aca?gcc?tat?gtt?gtt?ggc?gag?tcc?ggt?ctg?acc?act?gcg?ttg 403

Glu?Gly?Thr?Ala?Tyr?Val?Val?Gly?Glu?Ser?Gly?Leu?Thr?Thr?Ala?Leu

90 95 100

cat?acc?gcg?ggt?tgg?att?ttg?acg?gat?gca?aat?cct?gag?ttt?gtt?gtc 451

His?Thr?Ala?Gly?Trp?Ile?Leu?Thr?Asp?Ala?Asn?Pro?Glu?Phe?Val?Val

105 110 115

ctg?ggc?gaa?acc?cgc?aca?tat?tcc?ttc?gag?gca?atc?act?act?gcg?ata 499

Leu?Gly?Glu?Thr?Arg?Thr?Tyr?Ser?Phe?Glu?Ala?Ile?Thr?Thr?Ala?Ile

120 125 130

aat?ctg?att?ttg?ggt?ggc?gct?cgc?ttt?att?tgc?acc?aac?ccg?gat?gtc 547

Asn?Leu?Ile?Leu?Gly?Gly?Ala?Arg?Phe?Ile?Cys?Thr?Asn?Pro?Asp?Val

135 140 145

act?gga?cct?tca?cca?agt?ggc?att?ttg?cct?gct?act?ggc?tct?gtc?gcc 595

Thr?Gly?Pro?Ser?Pro?Ser?Gly?Ile?Leu?Pro?Ala?Thr?Gly?Ser?Val?Ala

150 155 160 165

gca?ctt?att?acc?gca?gct?act?ggc?gct?gag?cct?tat?tac?atc?ggc?aag 643

Ala?Leu?Ile?Thr?Ala?Ala?Thr?Gly?Ala?Glu?Pro?Tyr?Tyr?Ile?Gly?Lys

170 175 180

cca?aac?cct?gtg?atg?atg?cgc?agt?gcg?ctg?aac?acc?atc?ggg?gcg?cat 691

Pro?Asn?Pro?Val?Met?Met?Arg?Ser?Ala?Leu?Asn?Thr?Ile?Gly?Ala?His

185 190 195

tcc?gag?cac?act?gtc?atg?atc?ggc?gac?cgc?atg?gac?acc?gac?gtg?aaa 739

Ser?Glu?His?Thr?Val?Met?Ile?Gly?Asp?Arg?Met?Asp?Thr?Asp?Val?Lys

200 205 210

tct?ggt?ttg?gaa?gcc?ggc?ctg?agc?acc?gtg?ctg?gtt?cga?agc?gga?att 787

Ser?Gly?Leu?Glu?Ala?Gly?Leu?Ser?Thr?Val?Leu?Val?Arg?Ser?Gly?Ile

215 220 225

tcc?gac?gac?gcc?gag?atc?cgc?cgc?tac?ccc?ttc?cgc?cca?act?cac?gtg 835

Ser?Asp?Asp?Ala?Glu?Ile?Arg?Arg?Tyr?Pro?Phe?Arg?Pro?Thr?His?Val

230 235 240 245

atc?aat?tcc?atc?gcc?gat?ctt?gcc?gat?tgc?tgg?gac?gat?cct?ttc?ggt 883

Ile?Asn?Ser?Ile?Ala?Asp?Leu?Ala?Asp?Cys?Trp?Asp?Asp?Pro?Phe?Gly

250 255 260

gac?ggt?gca?ttt?cac?gta?cca?gat?gag?cag?cag?ttc?act?gac 925

Asp?Gly?Ala?Phe?His?Val?Pro?Asp?Glu?Gln?Gln?Phe?Thr?Asp

265 270 275

tagtattctg?taggtcatgg?cat 948

<210>164

<211>275

<212>PRT

＜213〉Corynebacterium glutamicum

<400>164

Met?Thr?Val?Asn?Ile?Ser?Tyr?Leu?Thr?Asp?Met?Asp?Gly?Val?Leu?Ile

1 5 10 15

Lys?Glu?Gly?Glu?Ile?Ile?Pro?Gly?Ala?Asp?Arg?Phe?Leu?Gln?Ser?Leu

20 25 30

Thr?Asp?Asn?Asn?Val?Glu?Phe?Met?Val?Leu?Thr?Asn?Asn?Ser?Ile?Phe

35 40 45

Thr?Pro?Arg?Asp?Leu?Ser?Ala?Arg?Leu?Lys?Thr?Ser?Gly?Leu?Asp?Ile

50 55 60

Pro?Pro?Glu?Arg?Ile?Trp?Thr?Ser?Ala?Thr?Ala?Thr?Ala?His?Phe?Leu

65 70 75 80

Lys?Ser?Gln?Val?Lys?Glu?Gly?Thr?Ala?Tyr?Val?Val?Gly?Glu?Ser?Gly

85 90 95

Leu?Thr?Thr?Ala?Leu?His?Thr?Ala?Gly?Trp?Ile?Leu?Thr?Asp?Ala?Asn

100 105 110

Pro?Glu?Phe?Val?Val?Leu?Gly?Glu?Thr?Arg?Thr?Tyr?Ser?Phe?Glu?Ala

115 120 125

Ile?Thr?Thr?Ala?Ile?Asn?Leu?Ile?Leu?Gly?Gly?Ala?Arg?Phe?Ile?Cys

130 135 140

Thr?Asn?Pro?Asp?Val?Thr?Gly?Pro?Ser?Pro?Ser?Gly?Ile?Leu?Pro?Ala

145 150 155 160

Thr?Gly?Ser?Val?Ala?Ala?Leu?Ile?Thr?Ala?Ala?Thr?Gly?Ala?Glu?Pro

165 170 175

Tyr?Tyr?Ile?Gly?Lys?Pro?Asn?Pro?Val?Met?Met?Arg?Ser?Ala?Leu?Asn

180 185 190

Thr?Ile?Gly?Ala?His?Ser?Glu?His?Thr?Val?Met?Ile?Gly?Asp?Arg?Met

195 200 205

Asp?Thr?Asp?Val?Lys?Ser?Gly?Leu?Glu?Ala?Gly?Leu?Ser?Thr?Val?Leu

210 215 220

Val?Arg?Ser?Gly?Ile?Ser?Asp?Asp?Ala?Glu?Ile?Arg?Arg?Tyr?Pro?Phe

225 230 235 240

Arg?Pro?Thr?His?Val?Ile?Asn?Ser?Ile?Ala?Asp?Leu?Ala?Asp?Cys?Trp

245 250 255

Asp?Asp?Pro?Phe?Gly?Asp?Gly?Ala?Phe?His?Val?Pro?Asp?Glu?Gln?Gln

260 265 270

Phe?Thr?Asp

275

<210>165

<211>1128

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1105)

<223>RXA00794

<400>165

gcgggttgat?acagcccaag?cgccgataca?tttataatgc?gcctagatac?gtgcaaccca?60

cgtaaccagg?tcagatcaag?tgccccagga?ggcccttcag?atg?aac?cta?aag?aac 115

Met?Asn?Leu?Lys?Asn

1 5

ccc?gaa?acg?cca?gac?cgt?aac?ctt?gct?atg?gag?ctg?gtg?cga?gtt?acg 163

Pro?Glu?Thr?Pro?Asp?Arg?Asn?Leu?Ala?Met?Glu?Leu?Val?Arg?Val?Thr

10 15 20

gaa?gca?gct?gca?ctg?gct?tct?gga?cgt?tgg?gtt?gga?cgt?ggc?atg?aag 211

Glu?Ala?Ala?Ala?Leu?Ala?Ser?Gly?Arg?Trp?Val?Gly?Arg?Gly?Met?Lys

25 30 35

aat?gaa?ggc?gac?ggt?gcc?gct?gtt?gac?gcc?atg?cgc?cag?ctc?atc?aac 259

Asn?Glu?Gly?Asp?Gly?Ala?Ala?Val?Asp?Ala?Met?Arg?Gln?Leu?Ile?Asn

40 45 50

tca?gtg?acc?atg?aag?ggc?gtc?gtt?gtt?atc?ggc?gag?ggc?gaa?aaa?gac 307

Ser?Val?Thr?Met?Lys?Gly?Val?Val?Val?Ile?Gly?Glu?Gly?Glu?Lys?Asp

55 60 65

gaa?gct?cca?atg?ctg?tac?aac?ggc?gaa?gag?gtc?gga?acc?ggc?ttt?gga 355

Glu?Ala?Pro?Met?Leu?Tyr?Asn?Gly?Glu?Glu?Val?Gly?Thr?Gly?Phe?Gly

70 75 80 85

cct?gag?gtt?gat?atc?gca?gtt?gac?cca?gtt?gac?ggc?acc?acc?ctg?atg 403

Pro?Glu?Val?Asp?Ile?Ala?Val?Asp?Pro?Val?Asp?Gly?Thr?Thr?Leu?Met

90 95 100

gct?gag?ggt?cgc?ccc?aac?gca?att?tcc?att?ctc?gca?gct?gca?gag?cgt 451

Ala?Glu?Gly?Arg?Pro?Asn?Ala?Ile?Ser?Ile?Leu?Ala?Ala?Ala?Glu?Arg

105 110 115

ggc?acc?atg?tac?gat?cca?tcc?tcc?gtc?ttc?tac?atg?aag?aag?atc?gcc 499

Gly?Thr?Met?Tyr?Asp?Pro?Ser?Ser?Val?Phe?Tyr?Met?Lys?Lys?Ile?Ala

120 125 130

gtg?gga?cct?gag?gcc?gca?ggc?aag?atc?gac?atc?gaa?gct?cca?gtt?gcc 547

Val?Gly?Pro?Glu?Ala?Ala?Gly?Lys?Ile?Asp?Ile?Glu?Ala?Pro?Val?Ala

135 140 145

cac?aac?atc?aac?gcg?gtg?gca?aag?tcc?aag?gga?atc?aac?cct?tcc?gac 595

His?Asn?Ile?Asn?Ala?Val?Ala?Lys?Ser?Lys?Gly?Ile?Asn?Pro?Ser?Asp

150 155 160 165

gtc?acc?gtt?gtc?gtg?ctt?gac?cgt?cct?cgc?cac?atc?gaa?ctg?atc?gca 643

Val?Thr?Val?Val?Val?Leu?Asp?Arg?Pro?Arg?His?Ile?Glu?Leu?Ile?Ala

170 175 180

gac?att?cgt?cgt?gca?ggc?gca?aag?gtt?cgt?ctc?atc?tcc?gac?ggc?gac 691

Asp?Ile?Arg?Arg?Ala?Gly?Ala?Lys?Val?Arg?Leu?Ile?Ser?Asp?Gly?Asp

185 190 195

gtt?gca?ggt?gca?gtt?gca?gca?gct?cag?gat?tcc?aac?tcc?gtg?gac?atc 739

Val?Ala?Gly?Ala?Val?Ala?Ala?Ala?Gln?Asp?Ser?Asn?Ser?Val?Asp?Ile

200 205 210

atg?atg?ggc?acc?ggc?gga?acc?cca?gaa?ggc?atc?atc?act?gcg?tgc?gcc 787

Met?Met?Gly?Thr?Gly?Gly?Thr?Pro?Glu?Gly?Ile?Ile?Thr?Ala?Cys?Ala

215 220 225

atg?aag?tgc?atg?ggt?ggc?gaa?atc?cag?ggc?atc?ctg?gcc?cca?atg?aac 835

Met?Lys?Cys?Met?Gly?Gly?Glu?Ile?Gln?Gly?Ile?Leu?Ala?Pro?Met?Asn

230 235 240 245

gat?ttc?gag?cgc?cag?aag?gca?cac?gac?gct?ggt?ctg?gtt?ctt?gat?cag 883

Asp?Phe?Glu?Arg?Gln?Lys?Ala?His?Asp?Ala?Gly?Leu?Val?Leu?Asp?Gln

250 255 260

gtt?ctg?cac?acc?aac?gat?ctg?gtg?agc?tcc?gac?aac?tgc?tac?ttc?gtg 931

Val?Leu?His?Thr?Asn?Asp?Leu?Val?Ser?Ser?Asp?Asn?Cys?Tyr?Phe?Val

265 270 275

gca?acc?ggt?gtg?acc?aac?ggt?gac?atg?ctc?cgt?ggc?gtt?tcc?tac?cgc 979

Ala?Thr?Gly?Val?Thr?Asn?Gly?Asp?Met?Leu?Arg?Gly?Val?Ser?Tyr?Arg

280 285 290

gca?aac?ggc?gca?acc?acc?cgt?tcc?ctg?gtt?atg?cgc?gca?aag?tca?ggc 1027

Ala?Asn?Gly?Ala?Thr?Thr?Arg?Ser?Leu?Val?Met?Arg?Ala?Lys?Ser?Gly

295 300 305

acc?atc?cgc?cac?atc?gag?tct?gtc?cac?cag?ctg?tcc?aag?ctg?cag?gaa 1075

Thr?Ile?Arg?His?Ile?Glu?Ser?Val?His?Gln?Leu?Ser?Lys?Leu?Gln?Glu

310 315 320 325

tac?tcc?gtg?gtt?gac?tac?acc?acc?gcg?acc?taagagctct?tagttcgaaa 1125

Tyr?Ser?Val?Val?Asp?Tyr?Thr?Thr?Ala?Thr

330 335

aac 1128

<210>166

<211>335

<212>PRT

＜213〉Corynebacterium glutamicum

<400>166

Met?Asn?Leu?Lys?Asn?Pro?Glu?Thr?Pro?Asp?Arg?Asn?Leu?Ala?Met?Glu

1 5 10 15

Leu?Val?Arg?Val?Thr?Glu?Ala?Ala?Ala?Leu?Ala?Ser?Gly?Arg?Trp?Val

20 25 30

Gly?Arg?Gly?Met?Lys?Asn?Glu?Gly?Asp?Gly?Ala?Ala?Val?Asp?Ala?Met

35 40 45

Arg?Gln?Leu?Ile?Asn?Ser?Val?Thr?Met?Lys?Gly?Val?Val?Val?Ile?Gly

50 55 60

Glu?Gly?Glu?Lys?Asp?Glu?Ala?Pro?Met?Leu?Tyr?Asn?Gly?Glu?Glu?Val

65 70 75 80

Gly?Thr?Gly?Phe?Gly?Pro?Glu?Val?Asp?Ile?Ala?Val?Asp?Pro?Val?Asp

85 90 95

Gly?Thr?Thr?Leu?Met?Ala?Glu?Gly?Arg?Pro?Asn?Ala?Ile?Ser?Ile?Leu

100 105 110

Ala?Ala?Ala?Glu?Arg?Gly?Thr?Met?Tyr?Asp?Pro?Ser?Ser?Val?Phe?Tyr

115 120 125

Met?Lys?Lys?Ile?Ala?Val?Gly?Pro?Glu?Ala?Ala?Gly?Lys?Ile?Asp?Ile

130 135 140

Glu?Ala?Pro?Val?Ala?His?Asn?Ile?Asn?Ala?Val?Ala?Lys?Ser?Lys?Gly

145 150 155 160

Ile?Asn?Pro?Ser?Asp?Val?Thr?Val?Val?Val?Leu?Asp?Arg?Pro?Arg?His

165 170 175

Ile?Glu?Leu?Ile?Ala?Asp?Ile?Arg?Arg?Ala?Gly?Ala?Lys?Val?Arg?Leu

180 185 190

Ile?Ser?Asp?Gly?Asp?Val?Ala?Gly?Ala?Val?Ala?Ala?Ala?Gln?Asp?Ser

195 200 205

Asn?Ser?Val?Asp?Ile?Met?Met?Gly?Thr?Gly?Gly?Thr?Pro?Glu?Gly?Ile

210 215 220

Ile?Thr?Ala?Cys?Ala?Met?Lys?Cys?Met?Gly?Gly?Glu?Ile?Gln?Gly?Ile

225 230 235 240

Leu?Ala?Pro?Met?Asn?Asp?Phe?Glu?Arg?Gln?Lys?Ala?His?Asp?Ala?Gly

245 250 255

Leu?Val?Leu?Asp?Gln?Val?Leu?His?Thr?Asn?Asp?Leu?Val?Ser?Ser?Asp

260 265 270

Asn?Cys?Tyr?Phe?Val?Ala?Thr?Gly?Val?Thr?Asn?Gly?Asp?Met?Leu?Arg

275 280 285

Gly?Val?Ser?Tyr?Arg?Ala?Asn?Gly?Ala?Thr?Thr?Arg?Ser?Leu?Val?Met

290 295 300

Arg?Ala?Lys?Ser?Gly?Thr?Ile?Arg?His?Ile?Glu?Ser?Val?His?Gln?Leu

305 310 315 320

Ser?Lys?Leu?Gln?Glu?Tyr?Ser?Val?Val?Asp?Tyr?Thr?Thr?Ala?Thr

325 330 335

<210>167

<211>1035

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1012)

<223>RXN02920

<400>167

tgcatgcaga?ttatctgtcc?aactacgcca?gccgcgcgta?aagcgcgggc?ctgctggtgg?60

cgggtggcgt?cgaaaagcat?ttttaaagga?gtttaagacg?atg?aag?ttt?gtt?atg 115

Met?Lys?Phe?Val?Met

1 5

tat?ccg?cat?ttg?tgg?gag?tcc?acg?acc?gct?gtc?att?gag?ggt?ggc?gga 163

Tyr?Pro?His?Leu?Trp?Glu?Ser?Thr?Thr?Ala?Val?Ile?Glu?Gly?Gly?Gly

10 15 20

cat?gag?cgg?gtt?gag?gat?att?aaa?gat?gca?gac?ttc?att?ttc?ttt?aat 211

His?Glu?Arg?Val?Glu?Asp?Ile?Lys?Asp?Ala?Asp?Phe?Ile?Phe?Phe?Asn

25 30 35

ggt?tca?gcg?ccg?gag?ttc?ccg?gat?ttg?ccg?gag?aac?atc?aag?ttc?gtg 259

Gly?Ser?Ala?Pro?Glu?Phe?Pro?Asp?Leu?Pro?Glu?Asn?Ile?Lys?Phe?Val

40 45 50

cag?gcc?tcc?atg?gcg?ggt?att?gat?gcg?ctg?gtc?aag?cgt?ggt?gtc?gtc 307

Gln?Ala?Ser?Met?Ala?Gly?Ile?Asp?Ala?Leu?Val?Lys?Arg?Gly?Val?Val

55 60 65

aat?gag?aag?gca?cgt?tgg?gca?aac?gcg?gct?ggc?ctg?tac?gct?gac?acc 355

Asn?Glu?Lys?Ala?Arg?Trp?Ala?Asn?Ala?Ala?Gly?Leu?Tyr?Ala?Asp?Thr

70 75 80 85

gtt?gct?gag?tcc?acc?att?ggt?tta?att?ctg?gcg?cag?atg?cac?atg?cat 403

Val?Ala?Glu?Ser?Thr?Ile?Gly?Leu?Ile?Leu?Ala?Gln?Met?His?Met?His

90 95 100

gcg?acg?act?cgt?ttg?gct?aag?tcg?tgg?agc?gtg?cgg?cct?gag?gtg?gaa 451

Ala?Thr?Thr?Arg?Leu?Ala?Lys?Ser?Trp?Ser?Val?Arg?Pro?Glu?Val?Glu

105 110 115

aac?aac?aag?tca?tgg?ctg?cat?gac?aat?aaa?act?gtc?gct?att?ttg?ggc 499

Asn?Asn?Lys?Ser?Trp?Leu?His?Asp?Asn?Lys?Thr?Val?Ala?Ile?Leu?Gly

120 125 130

gcc?ggt?ggc?att?ggc?gtg?cgt?ctg?ctg?gaa?atg?ctc?aag?ccg?ttc?aac 547

Ala?Gly?Gly?Ile?Gly?Val?Arg?Leu?Leu?Glu?Met?Leu?Lys?Pro?Phe?Asn

135 140 145

gtg?aag?acc?att?gcg?gtt?aat?aac?tct?ggt?cgt?ccg?gtg?gaa?ggt?gca 595

Val?Lys?Thr?Ile?Ala?Val?Asn?Asn?Ser?Gly?Arg?Pro?Val?Glu?Gly?Ala

150 155 160 165

gat?gaa?acc?ttc?gcc?atg?gat?aag?gct?gag?cac?gtg?tgg?gct?gag?gct 643

Asp?Glu?Thr?Phe?Ala?Met?Asp?Lys?Ala?Glu?His?Val?Trp?Ala?Glu?Ala

170 175 180

gat?gtg?ttt?gtg?ctc?atc?ctg?ccg?ctg?act?gat?gcc?act?tat?cag?atc 691

Asp?Val?Phe?Val?Leu?Ile?Leu?Pro?Leu?Thr?Asp?Ala?Thr?Tyr?Gln?Ile

185 190 195

gtc?aat?gca?gaa?act?ttg?ggc?aag?atg?aag?cct?tct?gcc?gtg?gtg?gtc 739

Val?Asn?Ala?Glu?Thr?Leu?Gly?Lys?Met?Lys?Pro?Ser?Ala?Val?Val?Val

200 205 210

aat?gtg?ggg?cgt?ggc?ccg?ctg?atc?aac?acc?gat?gat?ctg?gtg?gat?gca 787

Asn?Val?Gly?Arg?Gly?Pro?Leu?Ile?Asn?Thr?Asp?Asp?Leu?Val?Asp?Ala

215 220 225

ttg?aac?aac?ggc?acc?att?gcg?ggt?gct?gcg?ctg?gac?gtt?acc?gat?cct 835

Leu?Asn?Asn?Gly?Thr?Ile?Ala?Gly?Ala?Ala?Leu?Asp?Val?Thr?Asp?Pro

230 235 240 245

gag?cca?ctt?cct?gac?agc?cac?ccg?ctg?tgg?gag?atg?gac?aat?gtg?gtt 883

Glu?Pro?Leu?Pro?Asp?Ser?His?Pro?Leu?Trp?Glu?Met?Asp?Asn?Val?Val

250 255 260

atc?act?cct?cat?act?gca?aac?acg?aat?gag?agg?att?cgt?gct?ttg?acc 931

Ile?Thr?Pro?His?Thr?Ala?Asn?Thr?Asn?Glu?Arg?Ile?Arg?Ala?Leu?Thr

265 270 275

ggc?gaa?ctc?acc?ttg?cgc?aac?att?gag?ttg?ttt?gag?gca?ggc?gag?cag 979

Gly?Glu?Leu?Thr?Leu?Arg?Asn?Ile?Glu?Leu?Phe?Glu?Ala?Gly?Glu?Gln

280 285 290

atg?gcc?acc?gag?gtc?gat?gtg?gtg?gct?ggc?tac?taggcctttt?atggtgtgat 1032

Met?Ala?Thr?Glu?Val?Asp?Val?Val?Ala?Gly?Tyr

295 300

ccg 1035

<210>168

<211>304

<212>PRT

＜213〉Corynebacterium glutamicum

<400>168

Met?Lys?Phe?Val?Met?Tyr?Pro?His?Leu?Trp?Glu?Ser?Thr?Thr?Ala?Val

1 5 10 15

Ile?Glu?Gly?Gly?Gly?His?Glu?Arg?Val?Glu?Asp?Ile?Lys?Asp?Ala?Asp

20 25 30

Phe?Ile?Phe?Phe?Asn?Gly?Ser?Ala?Pro?Glu?Phe?Pro?Asp?Leu?Pro?Glu

35 40 45

Asn?Ile?Lys?Phe?Val?Gln?Ala?Ser?Met?Ala?Gly?Ile?Asp?Ala?Leu?Val

50 55 60

Lys?Arg?Gly?Val?Val?Asn?Glu?Lys?Ala?Arg?Trp?Ala?Asn?Ala?Ala?Gly

65 70 75 80

Leu?Tyr?Ala?Asp?Thr?Val?Ala?Glu?Ser?Thr?Ile?Gly?Leu?Ile?Leu?Ala

85 90 95

Gln?Met?His?Met?His?Ala?Thr?Thr?Arg?Leu?Ala?Lys?Ser?Trp?Ser?Val

100 105 110

Arg?Pro?Glu?Val?Glu?Asn?Asn?Lys?Ser?Trp?Leu?His?Asp?Asn?Lys?Thr

115 120 125

Val?Ala?Ile?Leu?Gly?Ala?Gly?Gly?Ile?Gly?Val?Arg?Leu?Leu?Glu?Met

130 135 140

Leu?Lys?Pro?Phe?Asn?Val?Lys?Thr?Ile?Ala?Val?Asn?Asn?Ser?Gly?Arg

145 150 155 160

Pro?Val?Glu?Gly?Ala?Asp?Glu?Thr?Phe?Ala?Met?Asp?Lys?Ala?Glu?His

165 170 175

Val?Trp?Ala?Glu?Ala?Asp?Val?Phe?Val?Leu?Ile?Leu?Pro?Leu?Thr?Asp

180 185 190

Ala?Thr?Tyr?Gln?Ile?Val?Asn?Ala?Glu?Thr?Leu?Gly?Lys?Met?Lys?Pro

195 200 205

Ser?Ala?Val?Val?Val?Asn?Val?Gly?Arg?Gly?Pro?Leu?Ile?Asn?Thr?Asp

210 215 220

Asp?Leu?Val?Asp?Ala?Leu?Asn?Asn?Gly?Thr?Ile?Ala?Gly?Ala?Ala?Leu

225 230 235 240

Asp?Val?Thr?Asp?Pro?Glu?Pro?Leu?Pro?Asp?Ser?His?Pro?Leu?Trp?Glu

245 250 255

Met?Asp?Asn?Val?Val?Ile?Thr?Pro?His?Thr?Ala?Asn?Thr?Asn?Glu?Arg

260 265 270

Ile?Arg?Ala?Leu?Thr?Gly?Glu?Leu?Thr?Leu?Arg?Asn?Ile?Glu?Leu?Phe

275 280 285

Glu?Ala?Gly?Glu?Gln?Met?Ala?Thr?Glu?Val?Asp?Val?Val?Ala?Gly?Tyr

290 295 300

<210>169

<211>779

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(52)..(756)

<223>FRXA02379

<400>169

tgcaggcctc?catggcgggt?attgatgcgc?tggtcaagcg?tggtgtcgtc?a?atg?aga 57

Met?Arg

1

aag?cac?cgt?tgg?gca?aac?gcg?gct?ggc?ctg?tac?gct?gac?acc?gtt?gct 105

Lys?His?Arg?Trp?Ala?Asn?Ala?Ala?Gly?Leu?Tyr?Ala?Asp?Thr?Val?Ala

5 10 15

gag?tcc?acc?att?ggt?tta?att?ctg?gcg?cag?atg?cac?atg?cat?gcg?acg 153

Glu?Ser?Thr?Ile?Gly?Leu?Ile?Leu?Ala?Gln?Met?His?Met?His?Ala?Thr

20 25 30

act?cgt?ttg?gct?aag?tcg?tgg?agc?gtg?cgg?cct?gag?gtg?gaa?aac?aac 201

Thr?Arg?Leu?Ala?Lys?Ser?Trp?Ser?Val?Arg?Pro?Glu?Val?Glu?Asn?Asn

35 40 45 50

aag?tca?tgg?ctg?cat?gac?aat?aaa?act?gtc?gct?att?ttg?ggc?gcc?ggt 249

Lys?Ser?Trp?Leu?His?Asp?Asn?Lys?Thr?Val?Ala?Ile?Leu?Gly?Ala?Gly

55 60 65

ggc?att?ggc?gtg?cgt?ctg?ctg?gaa?atg?ctc?aag?ccg?ttc?aac?gtg?aag 297

Gly?Ile?Gly?Val?Arg?Leu?Leu?Glu?Met?Leu?Lys?Pro?Phe?Asn?Val?Lys

70 75 80

acc?att?gcg?gtt?aat?aac?tct?ggt?cgt?ccg?gtg?gaa?ggt?gca?gat?gaa 345

Thr?Ile?Ala?Val?Asn?Asn?Ser?Gly?Arg?Pro?Val?Glu?Gly?Ala?Asp?Glu

85 90 95

acc?ttc?gcc?atg?gat?aag?gct?gag?cac?gtg?tgg?gct?gag?gct?gat?gtg 393

Thr?Phe?Ala?Met?Asp?Lys?Ala?Glu?His?Val?Trp?Ala?Glu?Ala?Asp?Val

100 105 110

ttt?gtg?ctc?atc?ctg?ccg?ctg?act?gat?gcc?act?tat?cag?atc?gtc?aat 441

Phe?Val?Leu?Ile?Leu?Pro?Leu?Thr?Asp?Ala?Thr?Tyr?Gln?Ile?Val?Asn

115 120 125 130

gca?gaa?act?ttg?ggc?aag?atg?aag?cct?tct?gcc?gtg?gtg?gtc?aat?gtg 489

Ala?Glu?Thr?Leu?Gly?Lys?Met?Lys?Pro?Ser?Ala?Val?Val?Val?Asn?Val

135 140 145

ggg?cgt?ggc?ccg?ctg?atc?aac?acc?gat?gat?ctg?gtg?gat?gca?ttg?aac 537

Gly?Arg?Gly?Pro?Leu?Ile?Asn?Thr?Asp?Asp?Leu?Val?Asp?Ala?Leu?Asn

150 155 160

aac?ggc?acc?att?gcg?ggt?gct?gcg?ctg?gac?gtt?acc?gat?cct?gag?cca 585

Asn?Gly?Thr?Ile?Ala?Gly?Ala?Ala?Leu?Asp?Val?Thr?Asp?Pro?Glu?Pro

165 170 175

ctt?cct?gac?agc?cac?ccg?ctg?tgg?gag?atg?gac?aat?gtg?gtt?atc?act 633

Leu?Pro?Asp?Ser?His?Pro?Leu?Trp?Glu?Met?Asp?Asn?Val?Val?Ile?Thr

180 185 190

cct?cat?act?gca?aac?acg?aat?gag?agg?att?cgt?gct?ttg?acc?ggc?gaa 681

Pro?His?Thr?Ala?Asn?Thr?Asn?Glu?Arg?Ile?Arg?Ala?Leu?Thr?Gly?Glu

195 200 205 210

ctc?acc?ttg?cgc?aac?att?gag?ttg?ttt?gag?gca?ggc?gag?cag?atg?gcc 729

Leu?Thr?Leu?Arg?Asn?Ile?Glu?Leu?Phe?Glu?Ala?Gly?Glu?Gln?Met?Ala

215 220 225

acc?gag?gtc?gat?gtg?gtg?gct?ggc?tac?taggcctttt?atggtgtgat?ccg 779

Thr?Glu?Val?Asp?Val?Val?Ala?Gly?Tyr

230 235

<210>170

<211>235

<212>PRT

＜213〉Corynebacterium glutamicum

<400>170

Met?Arg?Lys?His?Arg?Trp?Ala?Asn?Ala?Ala?Gly?Leu?Tyr?Ala?Asp?Thr

1 5 10 15

Val?Ala?Glu?Ser?Thr?Ile?Gly?Leu?Ile?Leu?Ala?Gln?Met?His?Met?His

20 25 30

Ala?Thr?Thr?Arg?Leu?Ala?Lys?Ser?Trp?Ser?Val?Arg?Pro?Glu?Val?Glu

35 40 45

Asn?Asn?Lys?Ser?Trp?Leu?His?Asp?Asn?Lys?Thr?Val?Ala?Ile?Leu?Gly

50 55 60

Ala?Gly?Gly?Ile?Gly?Val?Arg?Leu?Leu?Glu?Met?Leu?Lys?Pro?Phe?Asn

65 70 75 80

Val?Lys?Thr?Ile?Ala?Val?Asn?Asn?Ser?Gly?Arg?Pro?Val?Glu?Gly?Ala

85 90 95

Asp?Glu?Thr?Phe?Ala?Met?Asp?Lys?Ala?Glu?His?Val?Trp?Ala?Glu?Ala

100 105 110

Asp?Val?Phe?Val?Leu?Ile?Leu?Pro?Leu?Thr?Asp?Ala?Thr?Tyr?Gln?Ile

115 120 125

Val?Asn?Ala?Glu?Thr?Leu?Gly?Lys?Met?Lys?Pro?Ser?Ala?Val?Val?Val

130 135 140

Asn?Val?Gly?Arg?Gly?Pro?Leu?Ile?Asn?Thr?Asp?Asp?Leu?Val?Asp?Ala

145 150 155 160

Leu?Asn?Asn?Gly?Thr?Ile?Ala?Gly?Ala?Ala?Leu?Asp?Val?Thr?Asp?Pro

165 170 175

Glu?Pro?Leu?Pro?Asp?Ser?His?Pro?Leu?Trp?Glu?Met?Asp?Asn?Val?Val

180 185 190

Ile?Thr?Pro?His?Thr?Ala?Asn?Thr?Asn?Glu?Arg?Ile?Arg?Ala?Leu?Thr

195 200 205

Gly?Glu?Leu?Thr?Leu?Arg?Asn?Ile?Glu?Leu?Phe?Glu?Ala?Gly?Glu?Gln

210 215 220

Met?Ala?Thr?Glu?Val?Asp?Val?Val?Ala?Gly?Tyr

225 230 235

<210>171

<211>792

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(769)

<223>RXN02688

<400>171

gtgcggaaga?cagcacgccc?caaaccgacc?aactagctaa?gctacacaag?gcggacgaat?60

gggttcgcgc?agcaagcgaa?ggaaggaaac?ttaactagcc?atg?gcc?ggc?cgg?att 115

Met?Ala?Gly?Arg?Ile

1 5

att?ttg?cta?cga?cac?ggg?cag?act?cac?aac?aac?gtc?aaa?cac?ctc?ctg 163

Ile?Leu?Leu?Arg?His?Gly?Gln?Thr?His?Asn?Asn?Val?Lys?His?Leu?Leu

10 15 20

gac?acc?cgc?cca?cca?gga?gct?gaa?ctc?acc?gac?ctg?ggc?cgt?aaa?caa 211

Asp?Thr?Arg?Pro?Pro?Gly?Ala?Glu?Leu?Thr?Asp?Leu?Gly?Arg?Lys?Gln

25 30 35

gcc?ctt?gaa?gtt?ggc?cac?gaa?cta?gcc?acc?tac?tcc?ggt?gag?cgc?ctc 259

Ala?Leu?Glu?Val?Gly?His?Glu?Leu?Ala?Thr?Tyr?Ser?Gly?Glu?Arg?Leu

40 45 50

gcc?cat?gtg?tac?agc?tcc?atc?gtg?ttg?cgc?gcc?caa?caa?acc?gcc?gtg 307

Ala?His?Val?Tyr?Ser?Ser?Ile?Val?Leu?Arg?Ala?Gln?Gln?Thr?Ala?Val

55 60 65

ctt?gcc?acc?tct?acc?ttt?gaa?aaa?gct?cgc?gac?atg?cag?tcc?ggt?gcg 355

Leu?Ala?Thr?Ser?Thr?Phe?Glu?Lys?Ala?Arg?Asp?Met?Gln?Ser?Gly?Ala

70 75 80 85

att?cca?ctc?gac?gtt?gtg?gaa?ggc?att?cag?gaa?atc?aac?gtc?ggc?gac 403

Ile?Pro?Leu?Asp?Val?Val?Glu?Gly?Ile?Gln?Glu?Ile?Asn?Val?Gly?Asp

90 95 100

ttt?gaa?atg?cgc?ggc?gat?gaa?gaa?gcc?cac?atg?aat?tac?tcc?cgc?gca 451

Phe?Glu?Met?Arg?Gly?Asp?Glu?Glu?Ala?His?Met?Asn?Tyr?Ser?Arg?Ala

105 110 115

ctc?aac?ggc?tgg?ctt?cac?ggg?gat?cct?gcc?gct?ggt?ctt?ccc?ggc?ggt 499

Leu?Asn?Gly?Trp?Leu?His?Gly?Asp?Pro?Ala?Ala?Gly?Leu?Pro?Gly?Gly

120 125 130

gag?acc?tac?aaa?gac?gtg?ctg?aac?cgc?tac?cag?ccg?act?ctt?gat?cga 547

Glu?Thr?Tyr?Lys?Asp?Val?Leu?Asn?Arg?Tyr?Gln?Pro?Thr?Leu?Asp?Arg

135 140 145

atc?atg?gac?agc?cac?gac?ctt?gac?gac?gac?cgc?gac?gtt?gcc?gtt?gtc 595

Ile?Met?Asp?Ser?His?Asp?Leu?Asp?Asp?Asp?Arg?Asp?Val?Ala?Val?Val

150 155 160 165

agc?cac?ggc?gcc?gtc?atc?cgc?atc?gtg?gca?aca?cac?gca?act?ggt?gtg 643

Ser?His?Gly?Ala?Val?Ile?Arg?Ile?Val?Ala?Thr?His?Ala?Thr?Gly?Val

170 175 180

gat?ccc?aac?ttt?gcg?ttc?aac?acc?tac?ctg?ggc?aac?tgc?cgc?ttc?gtg 691

Asp?Pro?Asn?Phe?Ala?Phe?Asn?Thr?Tyr?Leu?Gly?Asn?Cys?Arg?Phe?Val

185 190 195

gtg?ctg?gag?cca?aac?ggt?aag?aaa?ttc?agc?caa?tgg?gat?gtt?gtg?cgc 739

Val?Leu?Glu?Pro?Asn?Gly?Lys?Lys?Phe?Ser?Gln?Trp?Asp?Val?Val?Arg

200 205 210

tgg?act?gac?agc?cca?ctg?cca?tgg?cag?gag?taattgagac?caaaggctcg 789

Trp?Thr?Asp?Ser?Pro?Leu?Pro?Trp?Gln?Glu

215 220

gat 792

<210>172

<211>223

<212>PRT

＜213〉Corynebacterium glutamicum

<400>172

Met?Ala?Gly?Arg?Ile?Ile?Leu?Leu?Arg?His?Gly?Gln?Thr?His?Asn?Asn

1 5 10 15

Val?Lys?His?Leu?Leu?Asp?Thr?Arg?Pro?Pro?Gly?Ala?Glu?Leu?Thr?Asp

20 25 30

Leu?Gly?Arg?Lys?Gln?Ala?Leu?Glu?Val?Gly?His?Glu?Leu?Ala?Thr?Tyr

35 40 45

Ser?Gly?Glu?Arg?Leu?Ala?His?Val?Tyr?Ser?Ser?Ile?Val?Leu?Arg?Ala

50 55 60

Gln?Gln?Thr?Ala?Val?Leu?Ala?Thr?Ser?Thr?Phe?Glu?Lys?Ala?Arg?Asp

65 70 75 80

Met?Gln?Ser?Gly?Ala?Ile?Pro?Leu?Asp?Val?Val?Glu?Gly?Ile?Gln?Glu

85 90 95

Ile?Asn?Val?Gly?Asp?Phe?Glu?Met?Arg?Gly?Asp?Glu?Glu?Ala?His?Met

100 105 110

Asn?Tyr?Ser?Arg?Ala?Leu?Asn?Gly?Trp?Leu?His?Gly?Asp?Pro?Ala?Ala

115 120 125

Gly?Leu?Pro?Gly?Gly?Glu?Thr?Tyr?Lys?Asp?Val?Leu?Asn?Arg?Tyr?Gln

130 135 140

Pro?Thr?Leu?Asp?Arg?Ile?Met?Asp?Ser?His?Asp?Leu?Asp?Asp?Asp?Arg

145 150 155 160

Asp?Val?Ala?Val?Val?Ser?His?Gly?Ala?Val?Ile?Arg?Ile?Val?Ala?Thr

165 170 175

His?Ala?Thr?Gly?Val?Asp?Pro?Asn?Phe?Ala?Phe?Asn?Thr?Tyr?Leu?Gly

180 185 190

Asn?Cys?Arg?Phe?Val?Val?Leu?Glu?Pro?Asn?Gly?Lys?Lys?Phe?Ser?Gln

195 200 205

Trp?Asp?Val?Val?Arg?Trp?Thr?Asp?Ser?Pro?Leu?Pro?Trp?Gln?Glu

210 215 220

<210>173

<211>336

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(313)

<223>RXN03087

<400>173

gttgccgcca?gccgttccag?ggcgcttgag?ctggtcagcg?acatcgcaat?gatcaaccag?60

gaatacctgg?aaaagagctg?atattgatag?ggtttaagtc?atg?aag?atc?tac?gca 115

Met?Lys?Ile?Tyr?Ala

1 5

cct?ttt?gct?gga?atc?gtc?cac?tat?ttt?gtc?gat?gaa?ggc?gat?ccc?gtg 163

Pro?Phe?Ala?Gly?Ile?Val?His?Tyr?Phe?Val?Asp?Glu?Gly?Asp?Pro?Val

10 15 20

gaa?acc?ggc?atg?caa?ctg?gga?acg?gta?gaa?acc?atc?aaa?ctc?gag?gca 211

Glu?Thr?Gly?Met?Gln?Leu?Gly?Thr?Val?Glu?Thr?Ile?Lys?Leu?Glu?Ala

25 30 35

cca?atc?atg?gca?ccg?gga?cct?ggc?atc?gta?gct?aag?gtt?tct?ttt?gat 259

Pro?Ile?Met?Ala?Pro?Gly?Pro?Gly?Ile?Val?Ala?Lys?Val?Ser?Phe?Asp

40 45 50

gat?ttc?tcc?gac?gtc?acc?ggc?ggc?gat?gaa?ctc?ctc?gaa?ttg?gag?gca 307

Asp?Phe?Ser?Asp?Val?Thr?Gly?Gly?Asp?Glu?Leu?Leu?Glu?Leu?Glu?Ala

55 60 65

aag?aac?taatgggtca?aacccgcatc?att 336

Lys?Asn

70

<210>174

<211>71

<212>PRT

＜213〉Corynebacterium glutamicum

<400>174

Met?Lys?Ile?Tyr?Ala?Pro?Phe?Ala?Gly?Ile?Val?His?Tyr?Phe?Val?Asp

1 5 10 15

Glu?Gly?Asp?Pro?Val?Glu?Thr?Gly?Met?Gln?Leu?Gly?Thr?Val?Glu?Thr

20 25 30

Ile?Lys?Leu?Glu?Ala?Pro?Ile?Met?Ala?Pro?Gly?Pro?Gly?Ile?Val?Ala

35 40 45

Lys?Val?Ser?Phe?Asp?Asp?Phe?Ser?Asp?Val?Thr?Gly?Gly?Asp?Glu?Leu

50 55 60

Leu?Glu?Leu?Glu?Ala?Lys?Asn

65 70

<210>175

<211>310

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(310)

<223>RXN03186

<400>175

ttcgtgcact?tcggcgtgtc?acaattaggt?acgaccaaga?atgggaccgg?gaaaccggga 60

cgtataaacg?aaataaaaca?ttccaacagg?aggtgtggaa?atg?gcc?gat?caa?gca 115

Met?Ala?Asp?Gln?Ala

1 5

aaa?ctt?ggt?ggc?aag?ccc?tcg?gat?gac?tct?aac?ttc?gcg?atg?atc?cgc 163

Lys?Leu?Gly?Gly?Lys?Pro?Ser?Asp?Asp?Ser?Asn?Phe?Ala?Met?Ile?Arg

10 15 20

gat?ggc?gtg?gca?tct?tat?ttg?aac?gac?tca?gat?ccg?gag?gag?acc?aac 211

Asp?Gly?Val?Ala?Ser?Tyr?Leu?Asn?Asp?Ser?Asp?Pro?Glu?Glu?Thr?Asn

25 30 35

gag?tgg?atg?gat?tca?ctc?gac?gga?tta?ctc?cag?gag?tct?tct?cca?gaa 259

Glu?Trp?Met?Asp?Ser?Leu?Asp?Gly?Leu?Leu?Gln?Glu?Ser?Ser?Pro?Glu

40 45 50

cgt?gct?cgt?tac?ctc?atg?ctt?cgt?ttg?ctt?gag?cgt?gca?tct?gca?aag 307

Arg?Ala?Arg?Tyr?Leu?Met?Leu?Arg?Leu?Leu?Glu?Arg?Ala?Ser?Ala?Lys

55 60 65

cgc 310

Arg

70

<210>176

<211>70

<212>PRT

＜213〉Corynebacterium glutamicum

<400>176

Met?Ala?Asp?Gln?Ala?Lys?Leu?Gly?Gly?Lys?Pro?Ser?Asp?Asp?Ser?Asn

1 5 10 15

Phe?Ala?Met?Ile?Arg?Asp?Gly?Val?Ala?Ser?Tyr?Leu?Asn?Asp?Ser?Asp

20 25 30

Pro?Glu?Glu?Thr?Asn?Glu?Trp?Met?Asp?Ser?Leu?Asp?Gly?Leu?Leu?Gln

35 40 45

Glu?Ser?Ser?Pro?Glu?Arg?Ala?Arg?Tyr?Leu?Met?Leu?Arg?Leu?Leu?Glu

50 55 60

Arg?Ala?Ser?Ala?Lys?Arg

65 70

<210>177

<211>302

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(279)

<223>RXN03187

<400>177

gtt?gca?gtg?tct?gac?ttc?tcc?act?gat?ctg?cca?aac?cag?atc?cgt?gaa 48

Val?Ala?Val?Ser?Asp?Phe?Ser?Thr?Asp?Leu?Pro?Asn?Gln?Ile?Arg?Glu

1 5 10 15

tgg?gtc?cca?ggc?gac?tac?acc?gtt?ctc?ggt?gca?gat?ggc?ttc?ggt?ttc 96

Trp?Val?Pro?Gly?Asp?Tyr?Thr?Val?Leu?Gly?Ala?Asp?Gly?Phe?Gly?Phe

20 25 30

tct?gat?acc?cgc?cca?gct?gct?cgt?cgc?ttc?ttc?aac?atc?gac?gct?gag 144

Ser?Asp?Thr?Arg?Pro?Ala?Ala?Arg?Arg?Phe?Phe?Asn?Ile?Asp?Ala?Glu

35 40 45

tcc?att?gtt?gtt?gca?gtg?ctg?aac?tcc?ctg?gca?cgc?gaa?ggc?aag?atc 192

Ser?Ile?Val?Val?Ala?Val?Leu?Asn?Ser?Leu?Ala?Arg?Glu?Gly?Lys?Ile

50 55 60

gac?gtc?tcc?gtt?gct?gct?cag?gct?gct?gag?aag?ttc?aag?ttg?gat?gat 240

Asp?Val?Ser?Val?Ala?Ala?Gln?Ala?Ala?Glu?Lys?Phe?Lys?Leu?Asp?Asp

65 70 75 80

cct?acg?agt?gtt?tcc?gta?gat?cca?aac?gct?cct?gag?gaa?taaatcacct 289

Pro?Thr?Ser?Val?Ser?Val?Asp?Pro?Asn?Ala?Pro?Glu?Glu

85 90

caagggacag?ata 302

<210>178

<211>93

<212>PRT

＜213〉Corynebacterium glutamicum

<400>178

Val?Ala?Val?Ser?Asp?Phe?Ser?Thr?Asp?Leu?Pro?Asn?Gln?Ile?Arg?Glu

1 5 10 15

Trp?Val?Pro?Gly?Asp?Tyr?Thr?Val?Leu?Gly?Ala?Asp?Gly?Phe?Gly?Phe

20 25 30

Ser?Asp?Thr?Arg?Pro?Ala?Ala?Arg?Arg?Phe?Phe?Asn?Ile?Asp?Ala?Glu

35 40 45

Ser?Ile?Val?Val?Ala?Val?Leu?Asn?Ser?Leu?Ala?Arg?Glu?Gly?Lys?Ile

50 55 60

Asp?Val?Ser?Val?Ala?Ala?Gln?Ala?Ala?Glu?Lys?Phe?Lys?Leu?Asp?Asp

65 70 75 80

Pro?Thr?Ser?Val?Ser?Val?Asp?Pro?Asn?Ala?Pro?Glu?Glu

85 90

<210>179

<211>1953

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1930)

<223>RXN02591

<400>179

atgtgtccgt?tgtctcacct?aaagttttaa?ctagttctgt?atctgaaagc?tacgctaggg?60

ggcgagaact?ctgtcgaatg?acacaaaatc?tggagaagta?atg?act?act?gct?gca 115

Met?Thr?Thr?Ala?Ala

1 5

atc?agg?ggc?ctt?cag?ggc?gag?gcg?ccg?acc?aag?aat?aag?gaa?ctg?ctg 163

Ile?Arg?Gly?Leu?Gln?Gly?Glu?Ala?Pro?Thr?Lys?Asn?Lys?Glu?Leu?Leu

10 15 20

aac?tgg?atc?gca?gac?gcc?gtc?gag?ctc?ttc?cag?cct?gag?gct?gtt?gtg 211

Asn?Trp?Ile?Ala?Asp?Ala?Val?Glu?Leu?Phe?Gln?Pro?Glu?Ala?Val?Val

25 30 35

ttc?gtt?gat?gga?tcc?cag?gct?gag?tgg?gat?cgc?atg?gcg?gag?gat?ctt 259

Phe?Val?Asp?Gly?Ser?Gln?Ala?Glu?Trp?Asp?Arg?Met?Ala?Glu?Asp?Leu

40 45 50

gtt?gaa?gcc?ggt?acc?ctc?atc?aag?ctc?aac?gag?gaa?aag?cgt?ccg?aac 307

Val?Glu?Ala?Gly?Thr?Leu?Ile?Lys?Leu?Asn?Glu?Glu?Lys?Arg?Pro?Asn

55 60 65

agc?tac?cta?gct?cgt?tcc?aac?cca?tct?gac?gtt?gcg?cgc?gtt?gag?tcc 355

Ser?Tyr?Leu?Ala?Arg?Ser?Asn?Pro?Ser?Asp?Val?Ala?Arg?Val?Glu?Ser

70 75 80 85

cgc?acc?ttc?atc?tgc?tcc?gag?aag?gaa?gaa?gat?gct?ggc?cca?acc?aac 403

Arg?Thr?Phe?Ile?Cys?Ser?Glu?Lys?Glu?Glu?Asp?Ala?Gly?Pro?Thr?Asn

90 95 100

aac?tgg?gct?cca?cca?cag?gca?atg?aag?gac?gaa?atg?tcc?aag?cat?tac 451

Asn?Trp?Ala?Pro?Pro?Gln?Ala?Met?Lys?Asp?Glu?Met?Ser?Lys?His?Tyr

105 110 115

gct?ggt?tcc?atg?aag?ggg?cgc?acc?atg?tac?gtc?gtg?cct?ttc?tgc?atg 499

Ala?Gly?Ser?Met?Lys?Gly?Arg?Thr?Met?Tyr?Val?Val?Pro?Phe?Cys?Met

120 125 130

ggt?cca?atc?agc?gat?ccg?gac?cct?aag?ctt?ggt?gtg?cag?ctc?act?gac 547

Gly?Pro?lle?Ser?Asp?Pro?Asp?Pro?Lys?Leu?Gly?Val?Gln?Leu?Thr?Asp

135 140 145

tcc?gag?tac?gtt?gtc?atg?tcc?atg?cgc?atc?atg?acc?cgc?atg?ggt?att 595

Ser?Glu?Tyr?Val?Val?Met?Ser?Met?Arg?Ile?Met?Thr?Arg?Met?Gly?Ile

150 155 160 165

gaa?gcg?ctg?gac?aag?atc?ggc?gcg?aac?ggc?agc?ttc?gtc?agg?tgc?ctc 643

Glu?Ala?Leu?Asp?Lys?Ile?Gly?Ala?Asn?Gly?Ser?Phe?Val?Arg?Cys?Leu

170 175 180

cac?tcc?gtt?ggt?gct?cct?ttg?gag?cca?ggc?cag?gaa?gac?gtt?gca?tgg 691

His?Ser?Val?Gly?Ala?Pro?Leu?Glu?Pro?Gly?Gln?Glu?Asp?Val?Ala?Trp

185 190 195

cct?tgc?aac?gac?acc?aag?tac?atc?acc?cag?ttc?cca?gag?acc?aag?gaa 739

Pro?Cys?Asn?Asp?Thr?Lys?Tyr?Ile?Thr?Gln?Phe?Pro?Glu?Thr?Lys?Glu

200 205 210

att?tgg?tcc?tac?ggt?tcc?ggc?tac?ggc?gga?aac?gca?atc?ctg?gca?aag 787

Ile?Trp?Ser?Tyr?Gly?Ser?Gly?Tyr?Gly?Gly?Asn?Ala?Ile?Leu?Ala?Lys

215 220 225

aag?tgc?tac?gca?ctg?cgt?atc?gca?tct?gtc?atg?gct?cgc?gaa?gaa?gga 835

Lys?Cys?Tyr?Ala?Leu?Arg?Ile?Ala?Ser?Val?Met?Ala?Arg?Glu?Glu?Gly

230 235 240 245

tgg?atg?gct?gag?cac?atg?ctc?atc?ctg?aag?ctg?atc?aac?cca?gag?ggc 883

Trp?Met?Ala?Glu?His?Met?Leu?Ile?Leu?Lys?Leu?Ile?Asn?Pro?Glu?Gly

250 255 260

aag?gcg?tac?cac?atc?gca?gca?gca?ttc?cca?tct?gct?tgt?ggc?aag?acc 931

Lys?Ala?Tyr?His?Ile?Ala?Ala?Ala?Phe?Pro?Ser?Ala?Cys?Gly?Lys?Thr

265 270 275

aac?ctc?gcc?atg?atc?act?cca?acc?atc?cca?ggc?tgg?acc?gct?cag?gtt 979

Asn?Leu?Ala?Met?Ile?Thr?Pro?Thr?Ile?Pro?Gly?Trp?Thr?Ala?Gln?Val

280 285 290

gtt?ggc?gac?gac?atc?gct?tgg?ctg?aag?ctg?cgc?gag?gac?ggc?ctc?tac 1027

Val?Gly?Asp?Asp?Ile?Ala?Trp?Leu?Lys?Leu?Arg?Glu?Asp?Gly?Leu?Tyr

295 300 305

gca?gtt?aac?cca?gaa?aat?ggt?ttc?ttc?ggt?gtt?gct?cca?ggc?acc?aac 1075

Ala?Val?Asn?Pro?Glu?Asn?Gly?Phe?Phe?Gly?Val?Ala?Pro?Gly?Thr?Asn

310 315 320 325

tac?gca?tcc?aac?cca?atc?gcg?atg?aag?acc?atg?gaa?cca?ggc?aac?acc 1123

Tyr?Ala?Ser?Asn?Pro?Ile?Ala?Met?Lys?Thr?Met?Glu?Pro?Gly?Asn?Thr

330 335 340

ctg?ttc?acc?aac?gtg?gca?ctc?acc?gac?gac?ggc?gac?atc?tgg?tgg?gaa 1171

Leu?Phe?Thr?Asn?Val?Ala?Leu?Thr?Asp?Asp?Gly?Asp?Ile?Trp?Trp?Glu

345 350 355

ggc?atg?gac?ggc?gac?gcc?cca?gct?cac?ctc?att?gac?tgg?atg?ggc?aac 1219

Gly?Met?Asp?Gly?Asp?Ala?Pro?Ala?His?Leu?Ile?Asp?Trp?Met?Gly?Asn

360 365 370

gac?tgg?acc?cca?gag?tcc?gac?gaa?aac?gct?gct?cac?cct?aac?tcc?cgt 1267

Asp?Trp?Thr?Pro?Glu?Ser?Asp?Glu?Asn?Ala?Ala?His?Pro?Asn?Ser?Arg

375 380 385

tac?tgc?gta?gca?atc?gac?cag?tcc?cca?gca?gca?gca?cct?gag?ttc?aac 1315

Tyr?Cys?Val?Ala?Ile?Asp?Gln?Ser?Pro?Ala?Ala?Ala?Pro?Glu?Phe?Asn

390 395 400 405

gac?tgg?gaa?ggc?gtc?aag?atc?gac?gca?atc?ctc?ttc?ggt?gga?cgt?cgc 1363

Asp?Trp?Glu?Gly?Val?Lys?Ile?Asp?Ala?Ile?Leu?Phe?Gly?Gly?Arg?Arg

410 415 420

gca?gac?acc?gtc?cca?ctg?gtt?acc?cag?acc?tac?gac?tgg?gag?cac?ggc 1411

Ala?Asp?Thr?Val?Pro?Leu?Val?Thr?Gln?Thr?Tyr?Asp?Trp?Glu?His?Gly

425 430 435

acc?atg?gtt?ggt?gca?ctg?ctc?gca?tcc?ggt?cag?acc?gca?gct?tcc?gca 1459

Thr?Met?Val?Gly?Ala?Leu?Leu?Ala?Ser?Gly?Gln?Thr?Ala?Ala?Ser?Ala

440 445 450

gaa?gca?aag?gtc?ggc?aca?ctc?cgc?cac?gac?cca?atg?gca?atg?ctc?cca 1507

Glu?Ala?Lys?Val?Gly?Thr?Leu?Arg?His?Asp?Pro?Met?Ala?Met?Leu?Pro

455 460 465

ttc?att?ggc?tac?aac?gct?ggt?gaa?tac?ctg?cag?aac?tgg?att?gac?atg 1555

Phe?Ile?Gly?Tyr?Asn?Ala?Gly?Glu?Tyr?Leu?Gln?Asn?Trp?Ile?Asp?Met

470 475 480 485

ggt?aac?aag?ggt?ggc?gac?aag?atg?cca?tcc?atc?ttc?ctg?gtc?aac?tgg 1603

Gly?Asn?Lys?Gly?Gly?Asp?Lys?Met?Pro?Ser?Ile?Phe?Leu?Val?Asn?Trp

490 495 500

ttc?cgc?cgt?ggc?gaa?gat?gga?cgc?ttc?ctg?tgg?cct?ggc?ttc?ggc?gac 1651

Phe?Arg?Arg?Gly?Glu?Asp?Gly?Arg?Phe?Leu?Trp?Pro?Gly?Phe?Gly?Asp

505 510 515

aac?tct?cgc?gtt?ctg?aag?tgg?gtc?atc?gac?cgc?atc?gaa?ggc?cac?gtt 1699

Asn?Ser?Arg?Val?Leu?Lys?Trp?Val?Ile?Asp?Arg?Ile?Glu?Gly?His?Val

520 525 530

ggc?gca?gac?gag?acc?gtt?gtt?gga?cac?acc?gct?aag?gcc?gaa?gac?ctc 1747

Gly?Ala?Asp?Glu?Thr?Val?Val?Gly?His?Thr?Ala?Lys?Ala?Glu?Asp?Leu

535 540 545

gac?ctc?gac?ggc?ctc?gac?acc?cca?att?gag?gat?gtc?aag?gaa?gca?ctg 1795

Asp?Leu?Asp?Gly?Leu?Asp?Thr?Pro?Ile?Glu?Asp?Val?Lys?Glu?Ala?Leu

550 555 560 565

acc?gct?cct?gca?gag?cag?tgg?gca?aac?gac?gtt?gaa?gac?aac?gcc?gag 1843

Thr?Ala?Pro?Ala?Glu?Gln?Trp?Ala?Asn?Asp?Val?Glu?Asp?Asn?Ala?Glu

570 575 580

tac?ctc?act?ttc?ctc?gga?cca?cgt?gtt?cct?gca?gag?gtt?cac?agc?cag 1891

Tyr?Leu?Thr?Phe?Leu?Gly?Pro?Arg?Val?Pro?Ala?Glu?Val?His?Ser?Gln

585 590 595

ttc?gat?gct?ctg?aag?gcc?cgc?att?tca?gca?gct?cac?gct?taaagttcac 1940

Phe?Asp?Ala?Leu?Lys?Ala?Arg?Ile?Ser?Ala?Ala?His?Ala

600 605 610

gcttaagaac?tgc 1953

<210>180

<211>610

<212>PRT

＜213〉Corynebacterium glutamicum

<400>180

Met?Thr?Thr?Ala?Ala?Ile?Arg?Gly?Leu?Gln?Gly?Glu?Ala?Pro?Thr?Lys

1 5 10 15

Asn?Lys?Glu?Leu?Leu?Asn?Trp?Ile?Ala?Asp?Ala?Val?Glu?Leu?Phe?Gln

20 25 30

Pro?Glu?Ala?Val?Val?Phe?Val?Asp?Gly?Ser?Gln?Ala?Glu?Trp?Asp?Arg

35 40 45

Met?Ala?Glu?Asp?Leu?Val?Glu?Ala?Gly?Thr?Leu?Ile?Lys?Leu?Asn?Glu

50 55 60

Glu?Lys?Arg?Pro?Asn?Ser?Tyr?Leu?Ala?Arg?Ser?Asn?Pro?Ser?Asp?Val

65 70 75 80

Ala?Arg?Val?Glu?Ser?Arg?Thr?Phe?Ile?Cys?Ser?Glu?Lys?Glu?Glu?Asp

85 90 95

Ala?Gly?Pro?Thr?Asn?Asn?Trp?Ala?Pro?Pro?Gln?Ala?Met?Lys?Asp?Glu

100 105 110

Met?Ser?Lys?His?Tyr?Ala?Gly?Ser?Met?Lys?Gly?Arg?Thr?Met?Tyr?Val

115 120 125

Val?Pro?Phe?Cys?Met?Gly?Pro?Ile?Ser?Asp?Pro?Asp?Pro?Lys?Leu?Gly

130 135 140

Val?Gln?Leu?Thr?Asp?Ser?Glu?Tyr?Val?Val?Met?Ser?Met?Arg?Ile?Met

145 150 155 160

Thr?Arg?Met?Gly?Ile?Glu?Ala?Leu?Asp?Lys?Ile?Gly?Ala?Asn?Gly?Ser

165 170 175

Phe?Val?Arg?Cys?Leu?His?Ser?Val?Gly?Ala?Pro?Leu?Glu?Pro?Gly?Gln

180 185 190

Glu?Asp?Val?Ala?Trp?Pro?Cys?Asn?Asp?Thr?Lys?Tyr?Ile?Thr?Gln?Phe

195 200 205

Pro?Glu?Thr?Lys?Glu?Ile?Trp?Ser?Tyr?Gly?Ser?Gly?Tyr?Gly?Gly?Asn

210 215 220

Ala?Ile?Leu?Ala?Lys?Lys?Cys?Tyr?Ala?Leu?Arg?Ile?Ala?Ser?Val?Met

225 230 235 240

Ala?Arg?Glu?Glu?Gly?Trp?Met?Ala?Glu?His?Met?Leu?Ile?Leu?Lys?Leu

245 250 255

Ile?Asn?Pro?Glu?Gly?Lys?Ala?Tyr?His?Ile?Ala?Ala?Ala?Phe?Pro?Ser

260 265 270

Ala?Cys?Gly?Lys?Thr?Asn?Leu?Ala?Met?Ile?Thr?Pro?Thr?Ile?Pro?Gly

275 280 285

Trp?Thr?Ala?Gln?Val?Val?Gly?Asp?Asp?Ile?Ala?Trp?Leu?Lys?Leu?Arg

290 295 300

Glu?Asp?Gly?Leu?Tyr?Ala?Val?Asn?Pro?Glu?Asn?Gly?Phe?Phe?Gly?Val

305 310 315 320

Ala?Pro?Gly?Thr?Asn?Tyr?Ala?Ser?Asn?Pro?Ile?Ala?Met?Lys?Thr?Met

325 330 335

Glu?Pro?Gly?Asn?Thr?Leu?Phe?Thr?Asn?Val?Ala?Leu?Thr?Asp?Asp?Gly

340 345 350

Asp?Ile?Trp?Trp?Glu?Gly?Met?Asp?Gly?Asp?Ala?Pro?Ala?His?Leu?Ile

355 360 365

Asp?Trp?Met?Gly?Asn?Asp?Trp?Thr?Pro?Glu?Ser?Asp?Glu?Asn?Ala?Ala

370 375 380

His?Pro?Asn?Ser?Arg?Tyr?Cys?Val?Ala?Ile?Asp?Gln?Ser?Pro?Ala?Ala

385 390 395 400

Ala?Pro?Glu?Phe?Asn?Asp?Trp?Glu?Gly?Val?Lys?Ile?Asp?Ala?Ile?Leu

405 410 415

Phe?Gly?Gly?Arg?Arg?Ala?Asp?Thr?Val?Pro?Leu?Val?Thr?Gln?Thr?Tyr

420 425 430

Asp?Trp?Glu?His?Gly?Thr?Met?Val?Gly?Ala?Leu?Leu?Ala?Ser?Gly?Gln

435 440 445

Thr?Ala?Ala?Ser?Ala?Glu?Ala?Lys?Val?Gly?Thr?Leu?Arg?His?Asp?Pro

450 455 460

Met?Ala?Met?Leu?Pro?Phe?Ile?Gly?Tyr?Asn?Ala?Gly?Glu?Tyr?Leu?Gln

465 470 475 480

Asn?Trp?Ile?Asp?Met?Gly?Asn?Lys?Gly?Gly?Asp?Lys?Met?Pro?Ser?Ile

485 490 495

Phe?Leu?Val?Asn?Trp?Phe?Arg?Arg?Gly?Glu?Asp?Gly?Arg?Phe?Leu?Trp

500 505 510

Pro?Gly?Phe?Gly?Asp?Asn?Ser?Arg?Val?Leu?Lys?Trp?Val?Ile?Asp?Arg

515 520 525

Ile?Glu?Gly?His?Val?Gly?Ala?Asp?Glu?Thr?Val?Val?Gly?His?Thr?Ala

530 535 540

Lys?Ala?Glu?Asp?Leu?Asp?Leu?Asp?Gly?Leu?Asp?Thr?Pro?Ile?Glu?Asp

545 550 555 560

Val?Lys?Glu?Ala?Leu?Thr?Ala?Pro?Ala?Glu?Gln?Trp?Ala?Asn?Asp?Val

565 570 575

Glu?Asp?Asn?Ala?Glu?Tyr?Leu?Thr?Phe?Leu?Gly?Pro?Arg?Val?Pro?Ala

580 585 590

Glu?Val?His?Ser?Gln?Phe?Asp?Ala?Leu?Lys?Ala?Arg?Ile?Ser?Ala?Ala

595 600 605

His?Ala

610

<210>181

<211>1305

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1282)

<223>RXS01260

<400>181

ctaaacgtgg?gctgcattcc?ttccaaagtc?tctgatcaaa?aacgctgaag?ttgcccatac?60

ctttacccat?gagaagaaga?ccttcggcat?caatggcgaa?gtg?acc?ttc?aac?tat 115

Val?Thr?Phe?Asn?Tyr

1 5

gag?gat?gct?cac?aag?cgt?tcc?cgt?ggc?gtt?tcc?gac?aag?atc?gtt?gga 163

Glu?Asp?Ala?His?Lys?Arg?Ser?Arg?Gly?Val?Ser?Asp?Lys?Ile?Val?Gly

10 15 20

ggc?gtt?cat?tac?ttg?atg?aag?aag?aac?aag?atc?atc?gaa?att?cat?ggt 211

Gly?Val?His?Tyr?Leu?Met?Lys?Lys?Asn?Lys?Ile?Ile?Glu?Ile?His?Gly

25 30 35

ctt?gga?aac?ttc?aag?gat?gct?aag?act?ctt?gag?gtc?acc?gac?ggt?aag 259

Leu?Gly?Asn?Phe?Lys?Asp?Ala?Lys?Thr?Leu?Glu?Val?Thr?Asp?Gly?Lys

40 45 50

gat?gct?ggc?aag?acc?atc?acc?ttt?gat?gac?tgc?atc?atc?gca?acc?ggt 307

Asp?Ala?Gly?Lys?Thr?Ile?Thr?Phe?Asp?Asp?Cys?Ile?Ile?Ala?Thr?Gly

55 60 65

tcg?gta?gtc?aac?acc?ctc?cgt?ggc?gtt?gac?ttc?tca?gag?aac?gtt?gtg 355

Ser?Val?Val?Asn?Thr?Leu?Arg?Gly?Val?Asp?Phe?Ser?Glu?Asn?Val?Val

70 75 80 85

tct?ttt?gaa?gag?cag?att?ctt?aac?cct?gtt?gcg?cca?aag?aag?atg?gtc 403

Ser?Phe?Glu?Glu?Gln?Ile?Leu?Asn?Pro?Val?Ala?Pro?Lys?Lys?Met?Val

90 95 100

att?gtt?ggt?gca?ggc?gca?att?gga?atg?gaa?ttc?gcc?tac?gtt?ctt?ggt 451

Ile?Val?Gly?Ala?Gly?Ala?Ile?Gly?Met?Glu?Phe?Ala?Tyr?Val?Leu?Gly

105 110 115

aac?tac?ggt?gta?gat?gta?acc?gtc?atc?gag?ttc?atg?gat?cgt?gtg?ctt 499

Asn?Tyr?Gly?Val?Asp?Val?Thr?Val?Ile?Glu?Phe?Met?Asp?Arg?Val?Leu

120 125 130

cca?aat?gaa?gat?gct?gaa?gtc?tcc?aag?gtt?att?gca?aag?gcc?tac?aag 547

Pro?Asn?Glu?Asp?Ala?Glu?Val?Ser?Lys?Val?Ile?Ala?Lys?Ala?Tyr?Lys

135 140 145

aag?atg?ggc?gtt?aag?ctt?ctt?cct?ggc?cat?gca?acc?act?gct?gtt?cgg 595

Lys?Met?Gly?Val?Lys?Leu?Leu?Pro?Gly?His?Ala?Thr?Thr?Ala?Val?Arg

150 155 160 165

gac?aac?ggt?gac?ttt?gtc?gag?gtt?gat?tac?cag?aag?aag?ggc?tct?gac 643

Asp?Asn?Gly?Asp?Phe?Val?Glu?Val?Asp?Tyr?Gln?Lys?Lys?Gly?Ser?Asp

170 175 180

aag?aca?gag?act?ctt?act?gtt?gat?cga?gtc?atg?gtt?tcc?gtt?ggt?ttc 691

Lys?Thr?Glu?Thr?Leu?Thr?Val?Asp?Arg?Val?Met?Val?Ser?Val?Gly?Phe

185 190 195

cgt?cca?cgc?gtt?gag?gga?ttt?ggt?ctt?gaa?aac?act?ggc?gtt?aag?ctc 739

Arg?Pro?Arg?Val?Glu?Gly?Phe?Gly?Leu?Glu?Asn?Thr?Gly?Val?Lys?Leu

200 205 210

acc?gag?cgt?ggc?gca?atc?gag?atc?gat?gat?tac?atg?cgt?acc?aac?gtc 787

Thr?Glu?Arg?Gly?Ala?Ile?Glu?Ile?Asp?Asp?Tyr?Met?Arg?Thr?Asn?Val

215 220 225

gat?ggc?att?tac?gcc?atc?ggt?gac?gtg?acc?gcc?aag?ctt?cag?ctt?gct 835

Asp?Gly?Ile?Tyr?Ala?Ile?Gly?Asp?Val?Thr?Ala?Lys?Leu?Gln?Leu?Ala

230 235 240 245

cac?gtc?gca?gaa?gca?cag?ggc?att?gtt?gcc?gca?gag?act?att?gct?ggt 883

His?Val?Ala?Glu?Ala?Gln?Gly?Ile?Val?Ala?Ala?Glu?Thr?Ile?Ala?Gly

250 255 260

gca?gaa?act?cag?act?ctt?ggt?gat?tac?atg?atg?atg?cca?cgt?gca?acc 931

Ala?Glu?Thr?Gln?Thr?Leu?Gly?Asp?Tyr?Met?Met?Met?Pro?Arg?Ala?Thr

265 270 275

ttc?tgc?aac?cca?cag?gtt?tct?tcc?ttt?ggt?tac?acc?gaa?gag?cag?gcc 979

Phe?Cys?Asn?Pro?Gln?Val?Ser?Ser?Phe?Gly?Tyr?Thr?Glu?Glu?Gln?Ala

280 285 290

aag?gag?aag?tgg?cca?gat?cgt?gag?atc?aag?gtt?gct?tcc?ttc?cca?ttc 1027

Lys?Glu?Lys?Trp?Pro?Asp?Arg?Glu?Ile?Lys?Val?Ala?Ser?Phe?Pro?Phe

295 300 305

tct?gca?aac?ggt?aaa?gca?gtt?ggc?ctg?gca?gaa?act?gat?ggt?ttc?gca 1075

Ser?Ala?Asn?Gly?Lys?Ala?Val?Gly?Leu?Ala?Glu?Thr?Asp?Gly?Phe?Ala

310 315 320 325

aag?atc?gtt?gct?gat?gca?gaa?ttc?ggt?gag?ctg?ctc?ggt?gca?cac?ctg 1123

Lys?Ile?Val?Ala?Asp?Ala?Glu?Phe?Gly?Glu?Leu?Leu?Gly?Ala?His?Leu

330 335 340

gtt?gga?gca?aat?gca?tca?gag?ctc?atc?aat?gaa?ttg?gtg?ctt?gct?cag 1171

Val?Gly?Ala?Asn?Ala?Ser?Glu?Leu?Ile?Asn?Glu?Leu?Val?Leu?Ala?Gln

345 350 355

aac?tgg?gat?ctc?acc?act?gaa?gag?atc?tct?cgt?agc?gtc?cat?att?cac 1219

Asn?Trp?Asp?Leu?Thr?Thr?Glu?Glu?Ile?Ser?Arg?Ser?Val?His?Ile?His

360 365 370

cca?acg?cta?tct?gag?gca?gtt?aag?gaa?gct?gca?cac?ggt?atc?tct?gga 1267

Pro?Thr?Leu?Ser?Glu?Ala?Val?Lys?Glu?Ala?Ala?His?Gly?Ile?Ser?Gly

375 380 385

cac?atg?atc?aac?ttc?tagaatccac?ctcgttggcc?ctg 1305

His?Met?Ile?Asn?Phe

390

<210>182

<211>394

<212>PRT

＜213〉Corynebacterium glutamicum

<400>182

Val?Thr?Phe?Asn?Tyr?Glu?Asp?Ala?His?Lys?Arg?Ser?Arg?Gly?Val?Ser

1 5 10 15

Asp?Lys?Ile?Val?Gly?Gly?Val?His?Tyr?Leu?Met?Lys?Lys?Asn?Lys?Ile

20 25 30

Ile?Glu?Ile?His?Gly?Leu?Gly?Asn?Phe?Lys?Asp?Ala?Lys?Thr?Leu?Glu

35 40 45

Val?Thr?Asp?Gly?Lys?Asp?Ala?Gly?Lys?Thr?Ile?Thr?Phe?Asp?Asp?Cys

50 55 60

Ile?Ile?Ala?Thr?Gly?Ser?Val?Val?Asn?Thr?Leu?Arg?Gly?Val?Asp?Phe

65 70 75 80

Ser?Glu?Asn?Val?Val?Ser?Phe?Glu?Glu?Gln?Ile?Leu?Asn?Pro?Val?Ala

85 90 95

Pro?Lys?Lys?Met?Val?Ile?Val?Gly?Ala?Gly?Ala?Ile?Gly?Met?Glu?Phe

100 105 110

Ala?Tyr?Val?Leu?Gly?Asn?Tyr?Gly?Val?Asp?Val?Thr?Val?Ile?Glu?Phe

115 120 125

Met?Asp?Arg?Val?Leu?Pro?Asn?Glu?Asp?Ala?Glu?Val?Ser?Lys?Val?Ile

130 135 140

Ala?Lys?Ala?Tyr?Lys?Lys?Met?Gly?Val?Lys?Leu?Leu?Pro?Gly?His?Ala

145 150 155 160

Thr?Thr?Ala?Val?Arg?Asp?Asn?Gly?Asp?Phe?Val?Glu?Val?Asp?Tyr?Gln

165 170 175

Lys?Lys?Gly?Ser?Asp?Lys?Thr?Glu?Thr?Leu?Thr?Val?Asp?Arg?Val?Met

180 185 190

Val?Ser?Val?Gly?Phe?Arg?Pro?Arg?Val?Glu?Gly?Phe?Gly?Leu?Glu?Asn

195 200 205

Thr?Gly?Val?Lys?Leu?Thr?Glu?Arg?Gly?Ala?Ile?Glu?Ile?Asp?Asp?Tyr

210 215 220

Met?Arg?Thr?Asn?Val?Asp?Gly?Ile?Tyr?Ala?Ile?Gly?Asp?Val?Thr?Ala

225 230 235 240

Lys?Leu?Gln?Leu?Ala?His?Val?Ala?Glu?Ala?Gln?Gly?Ile?Val?Ala?Ala

245 250 255

Glu?Thr?Ile?Ala?Gly?Ala?Glu?Thr?Gln?Thr?Leu?Gly?Asp?Tyr?Met?Met

260 265 270

Met?Pro?Arg?Ala?Thr?Phe?Cys?Asn?Pro?Gln?Val?Ser?Ser?Phe?Gly?Tyr

275 280 285

Thr?Glu?Glu?Gln?Ala?Lys?Glu?Lys?Trp?Pro?Asp?Arg?Glu?Ile?Lys?Val

290 295 300

Ala?Ser?Phe?Pro?Phe?Ser?Ala?Asn?Gly?Lys?Ala?Val?Gly?Leu?Ala?Glu

305 310 315 320

Thr?Asp?Gly?Phe?Ala?Lys?Ile?Val?Ala?Asp?Ala?Glu?Phe?Gly?Glu?Leu

325 330 335

Leu?Gly?Ala?His?Leu?Val?Gly?Ala?Asn?Ala?Ser?Glu?Leu?Ile?Asn?Glu

340 345 350

Leu?Val?Leu?Ala?Gln?Asn?Trp?Asp?Leu?Thr?Thr?Glu?Glu?Ile?Ser?Arg

355 360 365

Ser?Val?His?Ile?His?Pro?Thr?Leu?Ser?Glu?Ala?Val?Lys?Glu?Ala?Ala

370 375 380

His?Gly?Ile?Ser?Gly?His?Met?Ile?Asn?Phe

385 390

<210>183

<211>294

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(271)

<223>RXS01261

<400>183

gtgggtgttt?ttcattttct?tccactctaa?aattaagtat?ggaaaaccaa?ccgcacccgg?60

atgcacgaca?atgacccact?aaacacgtat?ccttgaatgc?gtg?act?gaa?cat?tat 115

Val?Thr?Glu?His?Tyr

1 5

gac?gta?gta?gta?ctc?gga?gcc?ggc?ccc?ggt?ggc?tat?gtc?tcc?gcc?atc 163

Asp?Val?Val?Val?Leu?Gly?Ala?Gly?Pro?Gly?Gly?Tyr?Val?Ser?Ala?Ile

10 15 20

cgt?gca?gcg?cag?ctt?ggc?aag?aag?gtt?gct?gta?att?gag?aag?cag?tac 211

Arg?Ala?Ala?Gln?Leu?Gly?Lys?Lys?Val?Ala?Val?Ile?Glu?Lys?Gln?Tyr

25 30 35

tgg?ggt?ggt?gtt?tgc?cta?aac?gtg?ggc?tgc?att?cct?tcc?aaa?gtc?tct 259

Trp?Gly?Gly?Val?Cys?Leu?Asn?Val?Gly?Cys?Ile?Pro?Ser?Lys?Val?Ser

40 45 50

gat?caa?aaa?cgc?tgaagttgcc?cataccttta?ccc 294

Asp?Gln?Lys?Arg

55

<210>184

<211>57

<212>PRT

＜213〉Corynebacterium glutamicum

<400>184

Val?Thr?Glu?His?Tyr?Asp?Val?Val?Val?Leu?Gly?Ala?Gly?Pro?Gly?Gly

1 5 10 15

Tyr?Val?Ser?Ala?Ile?Arg?Ala?Ala?Gln?Leu?Gly?Lys?Lys?Val?Ala?Val

20 25 30

Ile?Glu?Lys?Gln?Tyr?Trp?Gly?Gly?Val?Cys?Leu?Asn?Val?Gly?Cys?Ile

35 40 45

Pro?Ser?Lys?Val?Ser?Asp?Gln?Lys?Arg

50 55

<210>185

<211>1650

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1627)

<223>RXA02640

<400>185

accaacgacg?acgccggtgt?agcagatgta?ttggagtggt?ggttctaata?ggtggtgtta?60

aaacactgct?tagtggccca?atacgtgcaa?aaataaggcc?atg?aga?atc?tca?aag 115

Met?Arg?Ile?Ser?Lys

1 5

gcc?aat?gcg?tat?gtt?gca?gcg?att?gac?caa?ggc?acc?act?tcc?act?cgg 163

Ala?Asn?Ala?Tyr?Val?Ala?Ala?Ile?Asp?Gln?Gly?Thr?Thr?Ser?Thr?Arg

10 15 20

tgc?atc?ttc?att?gat?gcc?caa?gga?aaa?gtg?gtg?tct?tct?gct?tcc?aag 211

Cys?Ile?Phe?Ile?Asp?Ala?Gln?Gly?Lys?Val?Val?Ser?Ser?Ala?Ser?Lys

25 30 35

gag?cac?cgc?caa?atc?ttc?cca?caa?cag?ggc?tgg?gta?gag?cac?gat?cct 259

Glu?His?Arg?Gln?Ile?Phe?Pro?Gln?Gln?Gly?Trp?Val?Glu?His?Asp?Pro

40 45 50

gaa?gaa?att?tgg?gac?aac?att?cga?tct?gtc?gtc?agc?cag?gcg?atg?gtc 307

Glu?Glu?Ile?Trp?Asp?Asn?Ile?Arg?Ser?Val?Val?Ser?Gln?Ala?Met?Val

55 60 65

tcc?att?gac?atc?acc?cca?cac?gag?gtt?gca?tcg?ctg?gga?gtc?acc?aac 355

Ser?Ile?Asp?Ile?Thr?Pro?His?Glu?Val?Ala?Ser?Leu?Gly?Val?Thr?Asn

70 75 80 85

cag?cgc?gaa?acc?acc?gtg?gtg?tgg?gac?aag?cac?acc?ggc?gaa?cct?gtc 403

Gln?Arg?Glu?Thr?Thr?Val?Val?Trp?Asp?Lys?His?Thr?Gly?Glu?Pro?Val

90 95 100

tac?aac?gca?atc?gtg?tgg?caa?gac?acc?cgc?acc?tct?gac?att?tgc?cta 451

Tyr?Asn?Ala?Ile?Val?Trp?Gln?Asp?Thr?Arg?Thr?Ser?Asp?Ile?Cys?Leu

105 110 115

gag?atc?gcg?ggc?gaa?gaa?ggc?cag?gaa?aag?tgg?ctt?gac?cgc?acc?ggc 499

Glu?Ile?Ala?Gly?Glu?Glu?Gly?Gln?Glu?Lys?Trp?Leu?Asp?Arg?Thr?Gly

120 125 130

ctg?ctg?atc?aac?tcc?tac?cca?tcg?ggg?ccc?aaa?atc?aag?tgg?att?ctc 547

Leu?Leu?Ile?Asn?Ser?Tyr?Pro?Ser?Gly?Pro?Lys?Ile?Lys?Trp?Ile?Leu

135 140 145

gac?aac?gtt?gag?gga?gct?cgc?gaa?cgc?gcc?gaa?aag?ggc?gac?ctt?ttg 595

Asp?Asn?Val?Glu?Gly?Ala?Arg?Glu?Arg?Ala?Glu?Lys?Gly?Asp?Leu?Leu

150 155 160 165

ttt?ggc?acc?atg?gat?acc?tgg?gtg?ctg?tgg?aac?ctg?acc?ggc?ggt?gtc 643

Phe?Gly?Thr?Met?Asp?Thr?Trp?Val?Leu?Trp?Asn?Leu?Thr?Gly?Gly?Val

170 175 180

cgc?ggc?gac?gac?ggt?gat?gat?gcc?atc?cac?gtc?acc?gat?gtc?acc?aac 691

Arg?Gly?Asp?Asp?Gly?Asp?Asp?Ala?Ile?His?Val?Thr?Asp?Val?Thr?Asn

185 190 195

gca?tcc?cgc?aca?cta?ttg?atg?gat?ctc?cgc?acg?caa?cag?tgg?gat?cca 739

Ala?Ser?Arg?Thr?Leu?Leu?Met?Asp?Leu?Arg?Thr?Gln?Gln?Trp?Asp?Pro

200 205 210

gaa?cta?tgc?gaa?gcc?cta?gac?att?ccg?atg?tcc?atg?ctc?cct?gag?att 787

Glu?Leu?Cys?Glu?Ala?Leu?Asp?Ile?Pro?Met?Ser?Met?Leu?Pro?Glu?Ile

215 220 225

cgt?ccc?tcc?gtc?gga?gaa?ttc?cgc?tcc?gtg?cgc?cac?cgc?gga?acc?cta 835

Arg?Pro?Ser?Val?Gly?Glu?Phe?Arg?Ser?Val?Arg?His?Arg?Gly?Thr?Leu

230 235 240 245

gcc?gac?gtc?ccg?att?act?ggc?gtg?ctc?ggc?gac?cag?caa?gcg?gcc?ctt 883

Ala?Asp?Val?Pro?Ile?Thr?Gly?Val?Leu?Gly?Asp?Gln?Gln?Ala?Ala?Leu

250 255 260

ttt?ggt?cag?ggc?gga?ttc?cac?gaa?ggt?gct?gct?aaa?aat?acc?tac?ggc 931

Phe?Gly?Gln?Gly?Gly?Phe?His?Glu?Gly?Ala?Ala?Lys?Asn?Thr?Tyr?Gly

265 270 275

acc?ggc?ctc?ttc?ctg?ctg?atg?aac?acc?ggc?acc?tcg?ttg?aag?att?tcc 979

Thr?Gly?Leu?Phe?Leu?Leu?Met?Asn?Thr?Gly?Thr?Ser?Leu?Lys?Ile?Ser

280 285 290

gag?cac?ggc?ctg?ctg?tcc?acc?atc?gcc?tat?caa?cgg?gaa?gga?tcc?gct 1027

Glu?His?Gly?Leu?Leu?Ser?Thr?Ile?Ala?Tyr?Gln?Arg?Glu?Gly?Ser?Ala

295 300 305

ccg?gtc?tac?gcg?ctg?gaa?ggt?tcc?gta?tcc?atg?ggc?ggt?tcc?ttg?gtg 1075

Pro?Val?Tyr?Ala?Leu?Glu?Gly?Ser?Val?Ser?Met?Gly?Gly?Ser?Leu?Val

310 315 320 325

cag?tgg?ctg?cgc?gac?aac?cta?cag?cta?atc?ccc?aac?gca?cca?gcg?att 1123

Gln?Trp?Leu?Arg?Asp?Asn?Leu?Gln?Leu?Ile?Pro?Asn?Ala?Pro?Ala?Ile

330 335 340

gaa?aac?ctc?gcc?cga?gaa?gtc?gaa?gac?aac?ggt?ggc?gtt?cat?gtt?gtc 1171

Glu?Asn?Leu?Ala?Arg?Glu?Val?Glu?Asp?Asn?Gly?Gly?Val?His?Val?Val

345 350 355

cca?gca?ttc?acc?gga?ctg?ttc?gca?cca?cgt?tgg?cgc?ccc?gat?gct?cgt 1219

Pro?Ala?Phe?Thr?Gly?Leu?Phe?Ala?Pro?Arg?Trp?Arg?Pro?Asp?Ala?Arg

360 365 370

ggc?gtc?att?aca?ggc?ctc?acc?cgt?ttt?gcc?aac?cgc?aaa?cac?atc?gcc 1267

Gly?Val?Ile?Thr?Gly?Leu?Thr?Arg?Phe?Ala?Asn?Arg?Lys?His?Ile?Ala

375 380 385

cgc?gca?gtc?ctt?gaa?gcc?aac?gcc?ttc?caa?acc?cgc?gaa?gtt?gtg?gac 1315

Arg?Ala?Val?Leu?Glu?Ala?Asn?Ala?Phe?Gln?Thr?Arg?Glu?Val?Val?Asp

390 395 400 405

gcc?atg?gcc?aaa?gac?gca?ggc?aaa?gcc?ctc?gaa?tcc?ctc?cgc?gtc?gac 1363

Ala?Met?Ala?Lys?Asp?Ala?Gly?Lys?Ala?Leu?Glu?Ser?Leu?Arg?Val?Asp

410 415 420

ggt?gcg?atg?gtg?gaa?aat?gac?ctc?ctc?atg?caa?atg?caa?gcc?gac?ttc 1411

Gly?Ala?Met?Val?Glu?Asn?Asp?Leu?Leu?Met?Gln?Met?Gln?Ala?Asp?Phe

425 430 435

ctc?ggc?atc?gac?gtc?caa?cgt?ctc?gag?gac?gta?gaa?acc?acc?gcc?gtc 1459

Leu?Gly?Ile?Asp?Val?Gln?Arg?Leu?Glu?Asp?Val?Glu?Thr?Thr?Ala?Val

440 445 450

ggc?gtc?gca?ttc?gct?gca?ggt?ctc?ggc?tct?gga?ttc?ttc?aaa?aca?act 1507

Gly?Val?Ala?Phe?Ala?Ala?Gly?Leu?Gly?Ser?Gly?Phe?Phe?Lys?Thr?Thr

455 460 465

gac?gag?atc?gaa?aaa?ctt?att?gca?gtg?aag?aaa?gtc?tgg?aac?cct?gac 1555

Asp?Glu?Ile?Glu?Lys?Leu?Ile?Ala?Val?Lys?Lys?Val?Trp?Asn?Pro?Asp

470 475 480 485

atg?agc?gaa?gaa?gag?cgc?gaa?cgt?cgc?tat?gcc?gaa?tgg?aat?agg?gca 1603

Met?Ser?Glu?Glu?Glu?Arg?Glu?Arg?Arg?Tyr?Ala?Glu?Trp?Asn?Arg?Ala

490 495 500

gtg?gag?cat?tct?tat?gac?cag?gcc?tagctgattt?gggtcggcct?tta 1650

Val?Glu?His?Ser?Tyr?Asp?Gln?Ala

505

<210>186

<211>509

<212>PRT

＜213〉Corynebacterium glutamicum

<400>186

Met?Arg?Ile?Ser?Lys?Ala?Asn?Ala?Tyr?Val?Ala?Ala?Ile?Asp?Gln?Gly

1 5 10 15

Thr?Thr?Ser?Thr?Arg?Cys?Ile?Phe?Ile?Asp?Ala?Gln?Gly?Lys?Val?Val

20 25 30

Ser?Ser?Ala?Ser?Lys?Glu?His?Arg?Gln?Ile?Phe?Pro?Gln?Gln?Gly?Trp

35 40 45

Val?Glu?His?Asp?Pro?Glu?Glu?Ile?Trp?Asp?Asn?Ile?Arg?Ser?Val?Val

50 55 60

Ser?Gln?Ala?Met?Val?Ser?Ile?Asp?Ile?Thr?Pro?His?Glu?Val?Ala?Ser

65 70 75 80

Leu?Gly?Val?Thr?Asn?Gln?Arg?Glu?Thr?Thr?Val?Val?Trp?Asp?Lys?His

85 90 95

Thr?Gly?Glu?Pro?Val?Tyr?Asn?Ala?Ile?Val?Trp?Gln?Asp?Thr?Arg?Thr

100 105 110

Ser?Asp?Ile?Cys?Leu?Glu5Ile?Ala?Gly?Glu?Glu?Gly?Gln?Glu?Lys?Trp

115 120 125

Leu?Asp?Arg?Thr?Gly?Leu?Leu?Ile?Asn?Ser?Tyr?Pro?Ser?Gly?Pro?Lys

130 135 140

Ile?Lys?Trp?Ile?Leu?Asp?Asn?Val?Glu?Gly?Ala?Arg?Glu?Arg?Ala?Glu

145 150 155 160

Lys?Gly?Asp?Leu?Leu?Phe?Gly?Thr?Met?Asp?Thr?Trp?Val?Leu?Trp?Asn

165 170 175

Leu?Thr?Gly?Gly?Val?Arg?Gly?Asp?Asp?Gly?Asp?Asp?Ala?Ile?His?Val

180 185 190

Thr?Asp?Val?Thr?Asn?Ala?Ser?Arg?Thr?Leu?Leu?Met?Asp?Leu?Arg?Thr

195 200 205

Gln?Gln?Trp?Asp?Pro?Glu?Leu?Cys?Glu?Ala?Leu?Asp?Ile?Pro?Met?Ser

210 215 220

Met?Leu?Pro?Glu?Ile?Arg?Pro?Ser?Val?Gly?Glu?Phe?Arg?Ser?Val?Arg

225 230 235 240

His?Arg?Gly?Thr?Leu?Ala?Asp?Val?Pro?Ile?Thr?Gly?Val?Leu?Gly?Asp

245 250 255

Gln?Gln?Ala?Ala?Leu?Phe?Gly?Gln?Gly?Gly?Phe?His?Glu?Gly?Ala?Ala

260 265 270

Lys?Asn?Thr?Tyr?Gly?Thr?Gly?Leu?Phe?Leu?Leu?Met?Asn?Thr?Gly?Thr

275 280 285

Ser?Leu?Lys?Ile?Ser?Glu?His?Gly?Leu?Leu?Ser?Thr?Ile?Ala?Tyr?Gln

290 295 300

Arg?Glu?Gly?Ser?Ala?Pro?Val?Tyr?Ala?Leu?Glu?Gly?Ser?Val?Ser?Met

305 310 315 320

Gly?Gly?Ser?Leu?Val?Gln?Trp?Leu?Arg?Asp?Asn?Leu?Gln?Leu?Ile?Pro

325 330 335

Asn?Ala?Pro?Ala?Ile?Glu?Asn?Leu?Ala?Arg?Glu?Val?Glu?Asp?Asn?Gly

340 345 350

Gly?Val?His?Val?Val?Pro?Ala?Phe?Thr?Gly?Leu?Phe?Ala?Pro?Arg?Trp

355 360 365

Arg?Pro?Asp?Ala?Arg?Gly?Val?Ile?Thr?Gly?Leu?Thr?Arg?Phe?Ala?Ash

370 375 380

Arg?Lys?His?Ile?Ala?Arg?Ala?Val?Leu?Glu?Ala?Asn?Ala?Phe?Gln?Thr

385 390 395 400

Arg?Glu?Val?Val?Asp?Ala?Met?Ala?Lys?Asp?Ala?Gly?Lys?Ala?Leu?Glu

405 410 415

Ser?Leu?Arg?Val?Asp?Gly?Ala?Met?Val?Glu?Asn?Asp?Leu?Leu?Met?Gln

420 425 430

Met?Gln?Ala?Asp?Phe?Leu?Gly?Ile?Asp?Val?Gln?Arg?Leu?Glu?Asp?Val

435 440 445

Glu?Thr?Thr?Ala?Val?Gly?Val?Ala?Phe?Ala?Ala?Gly?Leu?Gly?Ser?Gly

450 455 460

Phe?Phe?Lys?Thr?Thr?Asp?Glu?Ile?Glu?Lys?Leu?Ile?Ala?Val?Lys?Lys

465 470 475 480

Val?Trp?Asn?Pro?Asp?Met?Ser?Glu?Glu?Glu?Arg?Glu?Arg?Arg?Tyr?Ala

485 490 495

Glu?Trp?Asn?Arg?Ala?Val?Glu?His?Ser?Tyr?Asp?Gln?Ala

500 505

<210>187

<211>1119

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1096)

<223>RXN01025

<400>187

gggcagcagc?ggcaggtttc?caggaggttt?ccatgcgggt?ggcttgggac?atgggctaac?60

ctgagacggt?taaatatcgt?tttcgaaagg?tgggtttcgc?gtg?gtt?tct?gta?agc 115

Val?Val?Ser?Val?Ser

1 5

gtg?atg?ggt?gca?ggt?tcc?tgg?gga?acc?acg?ttg?gcc?aag?gtc?ttc?tct 163

Val?Met?Gly?Ala?Gly?Ser?Trp?Gly?Thr?Thr?Leu?Ala?Lys?Val?Phe?Ser

10 15 20

gat?gct?ggc?aac?gct?gtg?acg?ttg?tgg?gcg?agg?cgg?gaa?gag?ttg?gca 211

Asp?Ala?Gly?Asn?Ala?Val?Thr?Leu?Trp?Ala?Arg?Arg?Glu?Glu?Leu?Ala

25 30 35

agc?acc?atc?cgt?gac?agc?cat?gaa?aac?cgt?gat?tac?ctt?ccg?ggg?att 259

Ser?Thr?Ile?Arg?Asp?Ser?His?Glu?Asn?Arg?Asp?Tyr?Leu?Pro?Gly?Ile

40 45 50

acg?ttg?ccg?gag?tcg?ctg?cag?gtc?aca?tca?tcg?gca?acg?gag?gct?tta 307

Thr?Leu?Pro?Glu?Ser?Leu?Gln?Val?Thr?Ser?Ser?Ala?Thr?Glu?Ala?Leu

55 60 65

gag?ggc?gca?gcc?att?gtg?gtg?ttg?gcg?att?cct?tcg?cag?gcg?ttg?cgt 355

Glu?Gly?Ala?Ala?Ile?Val?Val?Leu?Ala?Ile?Pro?Ser?Gln?Ala?Leu?Arg

70 75 80 85

ggc?aat?ttg?gcg?gag?tgg?aaa?gag?acg?atc?ccg?cag?gat?gcg?acc?ttg 403

Gly?Asn?Leu?Ala?Glu?Trp?Lys?Glu?Thr?Ile?Pro?Gln?Asp?Ala?Thr?Leu

90 95 100

gtg?tcc?ttg?gct?aaa?ggt?att?gaa?aag?ggc?acg?cac?ctg?cgg?atg?agt 451

Val?Ser?Leu?Ala?Lys?Gly?Ile?Glu?Lys?Gly?Thr?His?Leu?Arg?Met?Ser

105 110 115

gaa?gtg?atc?gcg?gag?gtg?acg?gaa?gcg?gat?cct?tca?cgc?atc?gcg?gtg 499

Glu?Val?Ile?Ala?Glu?Val?Thr?Glu?Ala?Asp?Pro?Ser?Arg?Ile?Ala?Val

120 125 130

ttg?tcg?ggg?cca?aac?ctt?gct?cgt?gag?atc?gcg?gag?ggg?cag?cct?gca 547

Leu?Ser?Gly?Pro?Asn?Leu?Ala?Arg?Glu?Ile?Ala?Glu?Gly?Gln?Pro?Ala

135 140 145

gct?acg?gtg?att?gct?tgc?cct?gat?gaa?aac?cga?gcg?aaa?ctt?gtg?cag 595

Ala?Thr?Val?Ile?Ala?Cys?Pro?Asp?Glu?Asn?Arg?Ala?Lys?Leu?Val?Gln

150 155 160 165

gct?gca?gtg?gct?gcg?ccg?tat?ttc?cgc?ccg?tac?acc?aac?act?gat?gtg 643

Ala?Ala?Val?Ala?Ala?Pro?Tyr?Phe?Arg?Pro?Tyr?Thr?Asn?Thr?Asp?Val

170 175 180

gtg?ggc?act?gaa?atc?ggt?ggt?gcg?tgt?aag?aac?gtc?atc?gcg?ctg?gcc 691

Val?Gly?Thr?Glu?Ile?Gly?Gly?Ala?Cys?Lys?Asn?Val?Ile?Ala?Leu?Ala

185 190 195

tgt?ggt?att?tcc?cat?ggt?tac?ggc?ctg?ggt?gag?aac?acc?aat?gca?tcg 739

Cys?Gly?Ile?Ser?His?Gly?Tyr?Gly?Leu?Gly?Glu?Asn?Thr?Asn?Ala?Ser

200 205 210

ttg?att?act?cgt?ggc?ctt?gca?gag?atc?gca?cgc?ctc?ggt?gcc?aca?ttg 787

Leu?Ile?Thr?Arg?Gly?Leu?Ala?Glu?Ile?Ala?Arg?Leu?Gly?Ala?Thr?Leu

215 220 225

ggt?gcg?gat?gcg?aag?act?ttt?tct?ggc?ctt?gcg?gga?atg?ggc?gac?ttg 835

Gly?Ala?Asp?Ala?Lys?Thr?Phe?Ser?Gly?Leu?Ala?Gly?Met?Gly?Asp?Leu

230 235 240 245

gtg?gct?acg?tgt?tca?tca?ccg?ctg?tcg?cgt?aac?cgc?agc?ttc?ggt?gag 883

Val?Ala?Thr?Cys?Ser?Ser?Pro?Leu?Ser?Arg?Asn?Arg?Ser?Phe?Gly?Glu

250 255 260

cgt?ttg?ggt?cag?ggt?gaa?tcc?cta?gag?aag?gct?cgc?gag?gca?acc?aat 931

Arg?Leu?Gly?Gln?Gly?Glu?Ser?Leu?Glu?Lys?Ala?Arg?Glu?Ala?Thr?Asn

265 270 275

ggt?cag?gtt?gcg?gag?ggt?gtt?att?tcc?tcg?cag?tcg?att?ttt?gat?ctt 979

Gly?Gln?Val?Ala?Glu?Gly?Val?Ile?Ser?Ser?Gln?Ser?Ile?Phe?Asp?Leu

280 285 290

gcc?acc?aag?ctt?ggt?gtg?gag?atg?ccg?atc?acc?cag?gct?gtc?tac?ggt 1027

Ala?Thr?Lys?Leu?Gly?Val?Glu?Met?Pro?Ile?Thr?Gln?Ala?Val?Tyr?Gly

295 300 305

gtg?tgc?cac?cga?gat?atg?aaa?gta?act?gac?atg?att?gtg?gct?ctc?atg 1075

Val?Cys?His?Arg?Asp?Met?Lys?Val?Thr?Asp?Met?Ile?Val?Ala?Leu?Met

310 315 320 325

ggc?agg?tct?aag?aag?gct?gag?tagtcttagg?ttgtaagctt?caa 1119

Gly?Arg?Ser?Lys?Lys?Ala?Glu

330

<210>188

<211>332

<212>PRT

＜213〉Corynebacterium glutamicum

<400>188

Val?Val?Ser?Val?Ser?Val?Met?Gly?Ala?Gly?Ser?Trp?Gly?Thr?Thr?Leu

1 5 10 15

Ala?Lys?Val?Phe?Ser?Asp?Ala?Gly?Asn?Ala?Val?Thr?Leu?Trp?Ala?Arg

20 25 30

Arg?Glu?Glu?Leu?Ala?Ser?Thr?Ile?Arg?Asp?Ser?His?Glu?Asn?Arg?Asp

35 40 45

Tyr?Leu?Pro?Gly?Ile?Thr?Leu?Pro?Glu?Ser?Leu?Gln?Val?Thr?Ser?Ser

50 55 60

Ala?Thr?Glu?Ala?Leu?Glu?Gly?Ala?Ala?Ile?Val?Val?Leu?Ala?Ile?Pro

65 70 75 80

Ser?Gln?Ala?Leu?Arg?Gly?Asn?Leu?Ala?Glu?Trp?Lys?Glu?Thr?Ile?Pro

85 90 95

Gln?Asp?Ala?Thr?Leu?Val?Ser?Leu?Ala?Lys?Gly?Ile?Glu?Lys?Gly?Thr

100 105 110

His?Leu?Arg?Met?Ser?Glu?Val?Ile?Ala?Glu?Val?Thr?Glu?Ala?Asp?Pro

115 120 125

Ser?Arg?Ile?Ala?Val?Leu?Ser?Gly?Pro?Asn?Leu?Ala?Arg?Glu?Ile?Ala

130 135 140

Glu?Gly?Gln?Pro?Ala?Ala?Thr?Val?Ile?Ala?Cys?Pro?Asp?Glu?Asn?Arg

145 150 155 160

Ala?Lys?Leu?Val?Gln?Ala?Ala?Val?Ala?Ala?Pro?Tyr?Phe?Arg?Pro?Tyr

165 170 175

Thr?Asn?Thr?Asp?Val?Val?Gly?Thr?Glu?Ile?Gly?Gly?Ala?Cys?Lys?Asn

180 185 190

Val?Ile?Ala?Leu?Ala?Cys?Gly?Ile?Ser?His?Gly?Tyr?Gly?Leu?Gly?Glu

195 200 205

Asn?Thr?Asn?Ala?Ser?Leu?Ile?Thr?Arg?Gly?Leu?Ala?Glu?Ile?Ala?Arg

210 215 220

Leu?Gly?Ala?Thr?Leu?Gly?Ala?Asp?Ala?Lys?Thr?Phe?Ser?Gly?Leu?Ala

225 230 235 240

Gly?Met?Gly?Asp?Leu?Val?Ala?Thr?Cys?Ser?Ser?Pro?Leu?Ser?Arg?Asn

245 250 255

Arg?Ser?Phe?Gly?Glu?Arg?Leu?Gly?Gln?Gly?Glu?Ser?Leu?Glu?Lys?Ala

260 265 270

Arg?Glu?Ala?Thr?Asn?Gly?Gln?Val?Ala?Glu?Gly?Val?Ile?Ser?Ser?Gln

275 280 285

Ser?Ile?Phe?Asp?Leu?Ala?Thr?Lys?Leu?Gly?Val?Glu?Met?Pro?Ile?Thr

290 295 300

Gln?Ala?Val?Tyr?Gly?Val?Cys?His?Arg?Asp?Met?Lys?Val?Thr?Asp?Met

305 310 315 320

Ile?Val?Ala?Leu?Met?Gly?Arg?Ser?Lys?Lys?Ala?Glu

325 330

<210>189

<211>1015

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1015)

<223>FRXA01025

<400>189

gggcagcagc?ggcaggtttc?cagraggttt?ccatgcgggt?ggcttggrac?wtgggctaac?60

ctgaracggt?taaatatcgt?tttcgaaagg?tgggtttcgc?gtg?gtt?tct?gta?agc 115

Val?Val?Ser?Val?Ser

1 5

gtg?atg?ggt?gca?ggt?tcc?tgg?gga?acc?acg?ttg?gcc?aag?gtc?ttc?tct 163

Val?Met?Gly?Ala?Gly?Ser?Trp?Gly?Thr?Thr?Leu?Ala?Lys?Val?Phe?Ser

10 15 20

gat?gct?ggc?aac?gct?gtg?acg?ttg?tgg?gcg?agg?cgg?gaa?gag?ttg?gca 211

Asp?Ala?Gly?Asn?Ala?Val?Thr?Leu?Trp?Ala?Arg?Arg?Glu?Glu?Leu?Ala

25 30 35

agc?acc?atc?cgt?gac?agc?cat?gaa?aac?cgt?gat?tac?ctt?ccg?ggg?att 259

Ser?Thr?Ile?Arg?Asp?Ser?His?Glu?Asn?Arg?Asp?Tyr?Leu?Pro?Gly?Ile

40 45 50

acg?ttg?ccg?gag?tcg?ctg?cag?gtc?aca?tca?tcg?gca?acg?gag?gct?tta 307

Thr?Leu?Pro?Glu?Ser?Leu?Gln?Val?Thr?Ser?Ser?Ala?Thr?Glu?Ala?Leu

55 60 65

gag?ggc?gca?gcc?att?gtg?gtg?ttg?gcg?att?cct?tcg?cag?gcg?ttg?cgt 355

Glu?Gly?Ala?Ala?Ile?Val?Val?Leu?Ala?Ile?Pro?Ser?Gln?Ala?Leu?Arg

70 75 80 85

ggc?aat?ttg?gcg?gag?tgg?aaa?gag?acg?atc?ccg?cag?gat?gcg?acc?ttg 403

Gly?Asn?Leu?Ala?Glu?Trp?Lys?Glu?Thr?Ile?Pro?Gln?Asp?Ala?Thr?Leu

90 95 100

gtg?tcc?ttg?gct?aaa?ggt?att?gaa?aag?ggc?acg?cac?ctg?cgg?atg?agt 451

Val?Ser?Leu?Ala?Lys?Gly?Ile?Glu?Lys?Gly?Thr?His?Leu?Arg?Met?Ser

105 110 115

gaa?gtg?atc?gcg?gag?gtg?acg?gaa?gcg?gat?cct?tca?cgc?atc?gcg?gtg 499

Glu?Val?Ile?Ala?Glu?Val?Thr?Glu?Ala?Asp?Pro?Ser?Arg?Ile?Ala?Val

120 125 130

ttg?tcg?ggg?cca?aac?ctt?gct?cgt?gag?atc?gcg?gag?ggg?cag?cct?gca 547

Leu?Ser?Gly?Pro?Asn?Leu?Ala?Arg?Glu?Ile?Ala?Glu?Gly?Gln?Pro?Ala

135 140 145

gct?acg?gtg?att?gct?tgc?cct?gat?gaa?aac?cga?gcg?aaa?ctt?gtg?cag 595

Ala?Thr?Val?Ile?Ala?Cys?Pro?Asp?Glu?Asn?Arg?Ala?Lys?Leu?Val?Gln

150 155 160 165

gct?gca?gtg?gct?gcg?ccg?tat?ttc?cgc?ccg?tac?acc?aac?act?gat?gtg 643

Ala?Ala?Val?Ala?Ala?Pro?Tyr?Phe?Arg?Pro?Tyr?Thr?Asn?Thr?Asp?Val

170 175 180

gtg?ggc?act?gaa?atc?ggt?ggt?gcg?tgt?aag?aac?gtc?atc?gcg?ctg?gcc 691

Val?Gly?Thr?Glu?Ile?Gly?Gly?Ala?Cys?Lys?Asn?Val?Ile?Ala?Leu?Ala

185 190 195

tgt?ggt?att?tcc?cat?ggt?tac?ggc?ctg?ggt?gag?aac?acc?aat?gca?tcg 739

Cys?Gly?Ile?Ser?His?Gly?Tyr?Gly?Leu?Gly?Glu?Asn?Thr?Asn?Ala?Ser

200 205 210

ttg?att?act?cgt?ggc?ctt?gca?gag?atc?gca?cgc?ctc?ggt?gcc?aca?ttg 787

Leu?Ile?Thr?Arg?Gly?Leu?Ala?Glu?Ile?Ala?Arg?Leu?Gly?Ala?Thr?Leu

215 220 225

ggt?gcg?gat?gcg?aag?act?ttt?tct?ggc?ctt?gcg?gga?atg?ggc?gac?ttg 835

Gly?Ala?Asp?Ala?Lys?Thr?Phe?Ser?Gly?Leu?Ala?Gly?Met?Gly?Asp?Leu

230 235 240 245

gtg?gct?acg?tgt?tca?tca?ccg?ctg?tcg?cgt?aac?cgc?agc?ttc?ggt?gag 883

Val?Ala?Thr?Cys?Ser?Ser?Pro?Leu?Ser?Arg?Asn?Arg?Ser?Phe?Gly?Glu

250 255 260

cgt?ttg?ggt?cag?ggt?gaa?tcc?cta?gag?aag?gct?cgc?gag?gca?acc?aat 931

Arg?Leu?Gly?Gln?Gly?Glu?Ser?Leu?Glu?Lys?Ala?Arg?Glu?Ala?Thr?Asn

265 270 275

ggt?cag?gtt?gcg?gag?ggt?gtt?att?tcc?tcg?cag?tcg?att?ttt?gat?ctt 979

Gly?Gln?Val?Ala?Glu?Gly?Val?Ile?Ser?Ser?Gln?Ser?Ile?Phe?Asp?Leu

280 285 290

gcc?acc?aag?ctt?ggt?gtg?gag?atg?ccg?atc?acc?cag 1015

Ala?Thr?Lys?Leu?Gly?Val?Glu?Met?Pro?Ile?Thr?Gln

295 300 305

<210>190

<211>305

<212>PRT

＜213〉Corynebacterium glutamicum

<400>190

Val?Val?Ser?Val?Ser?Val?Met?Gly?Ala?Gly?Ser?Trp?Gly?Thr?Thr?Leu

1 5 10 15

Ala?Lys?Val?Phe?Ser?Asp?Ala?Gly?Asn?Ala?Val?Thr?Leu?Trp?Ala?Arg

20 25 30

Arg?Glu?Glu?Leu?Ala?Ser?Thr?Ile?Arg?Asp?Ser?His?Glu?Asn?Arg?Asp

35 40 45

Tyr?Leu?Pro?Gly?Ile?Thr?Leu?Pro?Glu?Ser?Leu?Gln?Val?Thr?Ser?Ser

50 55 60

Ala?Thr?Glu?Ala?Leu?Glu?Gly?Ala?Ala?Ile?Val?Val?Leu?Ala?Ile?Pro

65 70 75 80

Ser?Gln?Ala?Leu?Arg?Gly?Asn?Leu?Ala?Glu?Trp?Lys?Glu?Thr?Ile?Pro

85 90 95

Gln?Asp?Ala?Thr?Leu?Val?Ser?Leu?Ala?Lys?Gly?Ile?Glu?Lys?Gly?Thr

100 105 110

His?Leu?Arg?Met?Ser?Glu?Val?Ile?Ala?Glu?Val?Thr?Glu?Ala?Asp?Pro

115 120 125

Ser?Arg?Ile?Ala?Val?Leu?Ser?Gly?Pro?Asn?Leu?Ala?Arg?Glu?Ile?Ala

130 135 140

Glu?Gly?Gln?Pro?Ala?Ala?Thr?Val?Ile?Ala?Cys?Pro?Asp?Glu?Asn?Arg

145 150 155 160

Ala?Lys?Leu?Val?Gln?Ala?Ala?Val?Ala?Ala?Pro?Tyr?Phe?Arg?Pro?Tyr

165 170 175

Thr?Asn?Thr?Asp?Val?Val?Gly?Thr?Glu?Ile?Gly?Gly?Ala?Cys?Lys?Asn

180 185 190

Val?Ile?Ala?Leu?Ala?Cys?Gly?Ile?Ser?His?Gly?Tyr?Gly?Leu?Gly?Glu

195 200 205

Asn?Thr?Asn?Ala?Ser?Leu?Ile?Thr?Arg?Gly?Leu?Ala?Glu?Ile?Ala?Arg

210 215 220

Leu?Gly?Ala?Thr?Leu?Gly?Ala?Asp?Ala?Lys?Thr?Phe?Ser?Gly?Leu?Ala

225 230 235 240

Gly?Met?Gly?Asp?Leu?Val?Ala?Thr?Cys?Ser?Ser?Pro?Leu?Ser?Arg?Asn

245 250 255

Arg?Ser?Phe?Gly?Glu?Arg?Leu?Gly?Gln?Gly?Glu?Ser?Leu?Glu?Lys?Ala

260 265 270

Arg?Glu?Ala?Thr?Asn?Gly?Gln?Val?Ala?Glu?Gly?Val?Ile?Ser?Ser?Gln

275 280 285

Ser?Ile?Phe?Asp?Leu?Ala?Thr?Lys?Leu?Gly?Val?Glu?Met?Pro?Ile?Thr

290 295 300

Gln

305

<210>191

<211>1809

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1786)

<223>RXA01851

<400>191

ttgtggcctt?tttgcagggg?aaacttattt?aaataattca?taagtaaaaa?accgtcaatt?60

cacgatgtgg?gttggcggtt?ttcctattag?gctcactttt?atg?acg?agc?gca?cac 115

Met?Thr?Ser?Ala?His

1 5

ttt?gaa?tcc?cgc?cgg?att?ggc?cct?ccg?ctt?cgc?gat?aat?tat?gac?gtc 163

Phe?Glu?Ser?Arg?Arg?Ile?Gly?Pro?Pro?Leu?Arg?Asp?Asn?Tyr?Asp?Val

10 15 20

att?gtg?att?ggc?ggt?ggt?atc?tca?ggt?gta?cag?att?gcg?cga?cat?gct 211

Ile?Val?Ile?Gly?Gly?Gly?Ile?Ser?Gly?Val?Gln?Ile?Ala?Arg?His?Ala

25 30 35

caa?ggc?cgc?ggt?tta?cgc?act?gtg?atg?ttt?gag?gcc?aga?gat?tat?tct 259

Gln?Gly?Arg?Gly?Leu?Arg?Thr?Val?Met?Phe?Glu?Ala?Arg?Asp?Tyr?Ser

40 45 50

tct?gga?aca?tca?tcg?aca?acc?tcc?aag?atg?att?cat?ggt?ggt?ttg?cgc 307

Ser?Gly?Thr?Ser?Ser?Thr?Thr?Ser?Lys?Met?Ile?His?Gly?Gly?Leu?Arg

55 60 65

tat?ttg?gag?cag?tac?gat?ttc?ggc?gtg?gtc?cag?gaa?gcc?gtg?aag?gaa 355

Tyr?Leu?Glu?Gln?Tyr?Asp?Phe?Gly?Val?Val?Gln?Glu?Ala?Val?Lys?Glu

70 75 80 85

cgc?cgg?tac?cta?ggt?atc?gcc?gct?ccg?cat?ttg?gtg?gct?cca?cgc?agt 403

Arg?Arg?Tyr?Leu?Gly?Ile?Ala?Ala?Pro?His?Leu?Val?Ala?Pro?Arg?Ser

90 95 100

ttc?atg?ctc?acg?gcg?ttt?gat?tgg?tca?gag?ccg?aaa?gcc?cct?atg?ttg 451

Phe?Met?Leu?Thr?Ala?Phe?Asp?Trp?Ser?Glu?Pro?Lys?Ala?Pro?Met?Leu

105 110 115

ggt?gct?ggt?gtg?gcg?ttg?tat?gaa?acg?atg?gcg?tgg?cag?cgt?aac?cag 499

Gly?Ala?Gly?Val?Ala?Leu?Tyr?Glu?Thr?Met?Ala?Trp?Gln?Arg?Asn?Gln

120 125 130

ggg?caa?tcg?aag?gaa?aac?cac?tcg?ccg?cgt?ttc?cgg?tgg?att?cct?aaa 547

Gly?Gln?Ser?Lys?Glu?Asn?His?Ser?Pro?Arg?Phe?Arg?Trp?Ile?Pro?Lys

135 140 145

aat?gca?ctg?ctc?aag?gaa?gtc?ccg?tgg?ctt?gac?ccg?gag?ggc?ttg?aag 595

Asn?Ala?Leu?Leu?Lys?Glu?Val?Pro?Trp?Leu?Asp?Pro?Glu?Gly?Leu?Lys

150 155 160 165

gga?gcg?tgg?cgc?cac?gat?gat?acg?ttg?aat?ctc?cat?gca?gaa?cga?ctc 643

Gly?Ala?Trp?Arg?His?Asp?Asp?Thr?Leu?Asn?Leu?His?Ala?Glu?Arg?Leu

170 175 180

ctc?ctc?gcg?gtg?att?aaa?gct?ttt?gcg?gca?gat?ggc?gga?acg?gcg?atc 691

Leu?Leu?Ala?Val?Ile?Lys?Ala?Phe?Ala?Ala?Asp?Gly?Gly?Thr?Ala?Ile

185 190 195

aac?cac?gcc?aaa?gtc?act?cgc?att?ctc?cgg?aac?gtg?gaa?gaa?ggc?cgc 739

Asn?His?Ala?Lys?Val?Thr?Arg?Ile?Leu?Arg?Asn?Val?Glu?Glu?Gly?Arg

200 205 210

gtc?aag?ggt?gta?gaa?gtg?act?gat?cag?gtc?acc?aac?acc?acg?cat?gag 787

Val?Lys?Gly?Val?Glu?Val?Thr?Asp?Gln?Val?Thr?Asn?Thr?Thr?His?Glu

215 220 225

gtg?aat?gcc?cct?gtg?gtg?atc?aac?gct?gcg?ggt?ccg?tgg?gtt?gcg?cag 835

Val?Asn?Ala?Pro?Val?Val?Ile?Asn?Ala?Ala?Gly?Pro?Trp?Val?Ala?Gln

230 235 240 245

gcg?ttg?ggt?gat?ttg?gcg?gag?gta?acc?aag?ttg?aag?gtg?cgc?caa?tcc 883

Ala?Leu?Gly?Asp?Leu?Ala?Glu?Val?Thr?Lys?Leu?Lys?Val?Arg?Gln?Ser

250 255 260

aag?gga?gtg?cat?ttg?ctc?act?ggt?gat?ttg?ggc?agc?cag?agt?ggc?gtg 931

Lys?Gly?Val?His?Leu?Leu?Thr?Gly?Asp?Leu?Gly?Ser?Gln?Ser?Gly?Val

265 270 275

ttt?gtg?cgt?ggc?aaa?aac?ggc?aag?cat?gtg?atc?gtg?aat?ccg?tgg?atg 979

Phe?Val?Arg?Gly?Lys?Asn?Gly?Lys?His?Val?Ile?Val?Asn?Pro?Trp?Met

280 285 290

ggg?cgc?acc?ctt?att?ggt?cca?acc?gac?acc?atg?att?gac?ggt?gac?gct 1027

Gly?Arg?Thr?Leu?Ile?Gly?Pro?Thr?Asp?Thr?Met?Ile?Asp?Gly?Asp?Ala

295 300 305

gat?gat?gcg?gct?gca?gat?gaa?agc?gat?atc?gat?ttg?ctg?ctt?gag?acc 1075

Asp?Asp?Ala?Ala?Ala?Asp?Glu?Ser?Asp?Ile?Asp?Leu?Leu?Leu?Glu?Thr

310 315 320 325

atc?gat?tcg?gta?cgc?gct?aca?ccg?ctt?gat?cgc?aaa?gag?atc?atc?tcc 1123

Ile?Asp?Ser?Val?Arg?Ala?Thr?Pro?Leu?Asp?Arg?Lys?Glu?Ile?Ile?Ser

330 335 340

acg?ctg?gtg?ggt?gtg?cgc?ccg?ctt?gtt?gat?gac?ggc?acc?gac?acc?tac 1171

Thr?Leu?Val?Gly?Val?Arg?Pro?Leu?Val?Asp?Asp?Gly?Thr?Asp?Thr?Tyr

345 350 355

acg?tcc?tct?cgc?cgt?ttc?gat?att?tcc?gat?cac?gcc?aac?gtc?ggc?att 1219

Thr?Ser?Ser?Arg?Arg?Phe?Asp?Ile?Ser?Asp?His?Ala?Asn?Val?Gly?Ile

360 365 370

gat?ggt?ttg?gtg?tct?gtc?tct?ggc?ggc?aag?tgg?acc?act?tcc?cgc?gtg 1267

Asp?Gly?Leu?Val?Ser?Val?Ser?Gly?Gly?Lys?Trp?Thr?Thr?Ser?Arg?Val

375 380 385

atg?ggg?tac?aag?gtg?att?gag?cat?gtg?gtg?gag?cac?caa?gct?gcg?gtg 1315

Met?Gly?Tyr?Lys?Val?Ile?Glu?His?Val?Val?Glu?His?Gln?Ala?Ala?Val

390 395 400 405

tta?cct?ccg?ctg?cgc?cac?ttt?gac?tcc?agg?cag?atg?ccg?ttg?agt?act 1363

Leu?Pro?Pro?Leu?Arg?His?Phe?Asp?Ser?Arg?Gln?Met?Pro?Leu?Ser?Thr

410 415 420

tct?ttt?ggc?gcg?tat?gag?tcc?gtg?gct?gat?tcc?ttt?gag?tca?gcg?ctt 1411

Ser?Phe?Gly?Ala?Tyr?Glu?Ser?Val?Ala?Asp?Ser?Phe?Glu?Ser?Ala?Leu

425 430 435

cgc?agc?cac?ccc?gag?ctg?gat?gtg?gat?gat?gaa?atc?cgc?gtg?cat?ctg 1459

Arg?Ser?His?Pro?Glu?Leu?Asp?Val?Asp?Asp?Glu?Ile?Arg?Val?His?Leu

440 445 450

gcc?aga?ctg?tat?gga?act?gag?cat?gaa?aaa?gtg?ctg?gat?ctc?gtc?gca 1507

Ala?Arg?Leu?Tyr?Gly?Thr?Glu?His?Glu?Lys?Val?Leu?Asp?Leu?Val?Ala

455 460 465

aag?caa?ccc?gac?ctg?ggg?cgc?cga?ctt?gac?cca?gac?aac?ctt?gat?atc 1555

Lys?Gln?Pro?Asp?Leu?Gly?Arg?Arg?Leu?Asp?Pro?Asp?Asn?Leu?Asp?Ile

470 475 480 485

gcg?gcg?cag?gcc?gtt?ttt?gct?gtc?gcc?gag?gag?gcg?gcc?gtc?gac?ctg 1603

Ala?Ala?Gln?Ala?Val?Phe?Ala?Val?Ala?Glu?Glu?Ala?Ala?Val?Asp?Leu

490 495 500

gcg?gac?gtg?ctg?gat?cgt?cgc?atc?gtg?ctc?ggc?acg?ctg?ggt?tat?gtg 1651

Ala?Asp?Val?Leu?Asp?Arg?Arg?Ile?Val?Leu?Gly?Thr?Leu?Gly?Tyr?Val

505 510 515

caa?ccg?gct?gcc?gtg?cgt?gcg?acg?gcc?gaa?gca?atg?gcg?cag?gtc?acc 1699

Gln?Pro?Ala?Ala?Val?Arg?Ala?Thr?Ala?Glu?Ala?Met?Ala?Gln?Val?Thr

520 525 530

ggg?tgg?tca?gct?gag?ctt?atc?gac?gcc?cag?tgc?cag?tcc?tac?ctc?gcc 1747

Gly?Trp?Ser?Ala?Glu?Leu?Ile?Asp?Ala?Gln?Cys?Gln?Ser?Tyr?Leu?Ala

535 540 545

aag?caa?gac?aaa?atc?caa?gcc?gtg?tta?aag?ccg?tac?cgc?taacactccg 1796

Lys?Gln?Asp?Lys?Ile?Gln?Ala?Val?Leu?Lys?Pro?Tyr?Arg

550 555 560

tcatcgacac?cgg 1809

<210>192

<211>562

<212>PRT

＜213〉Corynebacterium glutamicum

<400>192

Met?Thr?Ser?Ala?His?Phe?Glu?Ser?Arg?Arg?Ile?Gly?Pro?Pro?Leu?Arg

1 5 10 15

Asp?Asn?Tyr?Asp?Val?Ile?Val?Ile?Gly?Gly?Gly?Ile?Ser?Gly?Val?Gln

20 25 30

Ile?Ala?Arg?His?Ala?Gln?Gly?Arg?Gly?Leu?Arg?Thr?Val?Met?Phe?Glu

35 40 45

Ala?Arg?Asp?Tyr?Ser?Ser?Gly?Thr?Ser?Ser?Thr?Thr?Ser?Lys?Met?Ile

50 55 60

His?Gly?Gly?Leu?Arg?Tyr?Leu?Glu?Gln?Tyr?Asp?Phe?Gly?Val?Val?Gln

65 70 75 80

Glu?Ala?Val?Lys?Glu?Arg?Arg?Tyr?Leu?Gly?Ile?Ala?Ala?Pro?His?Leu

85 90 95

Val?Ala?Pro?Arg?Ser?Phe?Met?Leu?Thr?Ala?Phe?Asp?Trp?Ser?Glu?Pro

100 105 110

Lys?Ala?Pro?Met?Leu?Gly?Ala?Gly?Val?Ala?Leu?Tyr?Glu?Thr?Met?Ala

115 120 125

Trp?Gln?Arg?Asn?Gln?Gly?Gln?Ser?Lys?Glu?Asn?His?Ser?Pro?Arg?Phe

130 135 140

Arg?Trp?Ile?Pro?Lys?Asn?Ala?Leu?Leu?Lys?Glu?Val?Pro?Trp?Leu?Asp

145 150 155 160

Pro?Glu?Gly?Leu?Lys?Gly?Ala?Trp?Arg?His?Asp?Asp?Thr?Leu?Asn?Leu

165 170 175

His?Ala?Glu?Arg?Leu?Leu?Leu?Ala?Val?Ile?Lys?Ala?Phe?Ala?Ala?Asp

180 185 190

Gly?Gly?Thr?Ala?Ile?Asn?His?Ala?Lys?Val?Thr?Arg?Ile?Leu?Arg?Asn

195 200 205

Val?Glu?Glu?Gly?Arg?Val?Lys?Gly?Val?Glu?Val?Thr?Asp?Gln?Val?Thr

210 215 220

Asn?Thr?Thr?His?Glu?Val?Asn?Ala?Pro?Val?Val?Ile?Asn?Ala?Ala?Gly

225 230 235 240

Pro?Trp?Val?Ala?Gln?Ala?Leu?Gly?Asp?Leu?Ala?Glu?Val?Thr?Lys?Leu

245 250 255

Lys?Val?Arg?Gln?Ser?Lys?Gly?Val?His?Leu?Leu?Thr?Gly?Asp?Leu?Gly

260 265 270

Ser?Gln?Ser?Gly?Val?Phe?Val?Arg?Gly?Lys?Asn?Gly?Lys?His?Val?Ile

275 280 285

Val?Asn?Pro?Trp?Met?Gly?Arg?Thr?Leu?Ile?Gly?Pro?Thr?Asp?Thr?Met

290 295 300

Ile?Asp?Gly?Asp?Ala?Asp?Asp?Ala?Ala?Ala?Asp?Glu?Ser?Asp?Ile?Asp

305 310 315 320

Leu?Leu?Leu?Glu?Thr?Ile?Asp?Ser?Val?Arg?Ala?Thr?Pro?Leu?Asp?Arg

325 330 335

Lys?Glu?Ile?Ile?Ser?Thr?Leu?Val?Gly?Val?Arg?Pro?Leu?Val?Asp?Asp

340 345 350

Gly?Thr?Asp?Thr?Tyr?Thr?Ser?Ser?Arg?Arg?Phe?Asp?Ile?Ser?Asp?His

355 360 365

Ala?Asn?Val?Gly?Ile?Asp?Gly?Leu?Val?Ser?Val?Ser?Gly?Gly?Lys?Trp

370 375 380

Thr?Thr?Ser?Arg?Val?Met?Gly?Tyr?Lys?Val?Ile?Glu?His?Val?Val?Glu

385 390 395 400

His?Gln?Ala?Ala?Val?Leu?Pro?Pro?Leu?Arg?His?Phe?Asp?Ser?Arg?Gln

405 410 415

Met?Pro?Leu?Ser?Thr?Ser?Phe?Gly?Ala?Tyr?Glu?Ser?Val?Ala?Asp?Ser

420 425 430

Phe?Glu?Ser?Ala?Leu?Arg?Ser?His?Pro?Glu?Leu?Asp?Val?Asp?Asp?Glu

435 440 445

Ile?Arg?Val?His?Leu?Ala?Arg?Leu?Tyr?Gly?Thr?Glu?His?Glu?Lys?Val

450 455 460

Leu?Asp?Leu?Val?Ala?Lys?Gln?Pro?Asp?Leu?Gly?Arg?Arg?Leu?Asp?Pro

465 470 475 480

Asp?Asn?Leu?Asp?Ile?Ala?Ala?Gln?Ala?Val?Phe?Ala?Val?Ala?Glu?Glu

485 490 495

Ala?Ala?Val?Asp?Leu?Ala?Asp?Val?Leu?Asp?Arg?Arg?Ile?Val?Leu?Gly

500 505 510

Thr?Leu?Gly?Tyr?Val?Gln?Pro?Ala?Ala?Val?Arg?Ala?Thr?Ala?Glu?Ala

515 520 525

Met?Ala?Gln?Val?Thr?Gly?Trp?Ser?Ala?Glu?Leu?Ile?Asp?Ala?Gln?Cys

530 535 540

Gln?Ser?Tyr?Leu?Ala?Lys?Gln?Asp?Lys?Ile?Gln?Ala?Val?Leu?Lys?Pro

545 550 555 560

Tyr?Arg

<210>193

<211>900

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(877)

<223>RXA01242

<400>193

cgccggcaac?caaatgaggc?ttttgggcgt?tggacagtga?gacaatgggt?aagaaattcg?60

gacatattta?gtaaattggc?tttttgcttt?aaggagtgac?atg?tac?gca?gag?gag 115

Met?Tyr?Ala?Glu?Glu

1 5

cgc?cgt?cga?cag?att?gcc?tca?tta?acg?gca?gtt?gag?gga?cgt?gta?aat 163

Arg?Arg?Arg?Gln?Ile?Ala?Ser?Leu?Thr?Ala?Val?Glu?Gly?Arg?Val?Asn

10 15 20

gtc?aca?gaa?tta?gcg?ggc?cga?ttc?gat?gtc?act?gca?gag?acg?att?cga 211

Val?Thr?Glu?Leu?Ala?Gly?Arg?Phe?Asp?Val?Thr?Ala?Glu?Thr?Ile?Arg

25 30 35

cga?gac?ctt?gcg?gtg?cta?gac?cgc?gag?gga?att?gtt?cac?cgc?gtt?cac 259

Arg?Asp?Leu?Ala?Val?Leu?Asp?Arg?Glu?Gly?Ile?Val?His?Arg?Val?His

40 45 50

ggt?ggc?gca?gta?gcc?acc?caa?tct?ttc?caa?acc?aca?gag?ttg?agc?ttg 307

Gly?Gly?Ala?Val?Ala?Thr?Gln?Ser?Phe?Gln?Thr?Thr?Glu?Leu?Ser?Leu

55 60 65

gat?act?cgt?ttc?agg?tct?gca?tcg?tca?gca?aag?tac?tcc?att?gcc?aag 355

Asp?Thr?Arg?Phe?Arg?Ser?Ala?Ser?Ser?Ala?Lys?Tyr?Ser?Ile?Ala?Lys

70 75 80 85

gca?gcg?atg?cag?ttc?ctg?ccc?gct?gag?cat?ggc?gga?ctg?ttc?ctc?gat 403

Ala?Ala?Met?Gln?Phe?Leu?Pro?Ala?Glu?His?Gly?Gly?Leu?Phe?Leu?Asp

90 95 100

gcg?gga?act?act?gtt?act?gct?ttg?gcc?gat?ctc?att?tct?gag?cat?cct 451

Ala?Gly?Thr?Thr?Val?Thr?Ala?Leu?Ala?Asp?Leu?Ile?Ser?Glu?His?Pro

105 110 115

agc?tcc?aag?cag?tgg?tcg?atc?gtg?acc?aac?tgc?ctc?ccc?atc?gca?ctt 499

Ser?Ser?Lys?Gln?Trp?Ser?Ile?Val?Thr?Asn?Cys?Leu?Pro?Ile?Ala?Leu

120 125 130

aat?ctg?gcc?aac?gcc?ggg?ctt?gat?gat?gtc?cag?ctg?ctt?gga?gga?agc 547

Asn?Leu?Ala?Asn?Ala?Gly?Leu?Asp?Asp?Val?Gln?Leu?Leu?Gly?Gly?Ser

135 140 145

gtt?cgc?gcg?atc?acc?cag?gct?gtt?gtg?ggt?gac?act?gcg?ctt?cgt?act 595

Val?Arg?Ala?Ile?Thr?Gln?Ala?Val?Val?Gly?Asp?Thr?Ala?Leu?Arg?Thr

150 155 160 165

ctc?gcg?ctg?atg?cgt?gcg?gat?gta?gtg?ttc?atc?ggc?acc?aac?gcg?ttg 643

Leu?Ala?Leu?Met?Arg?Ala?Asp?Val?Val?Phe?Ile?Gly?Thr?Asn?Ala?Leu

170 175 180

acg?ttg?gat?cac?gga?ttg?tct?acg?gcc?gat?tcc?caa?gag?gct?gcc?atg 691

Thr?Leu?Asp?His?Gly?Leu?Ser?Thr?Ala?Asp?Ser?Gln?Glu?Ala?Ala?Met

185 190 195

aaa?tct?gcg?atg?atc?acc?aac?gcc?cac?aag?gtg?gtg?gtg?ttg?tgt?gac 739

Lys?Ser?Ala?Met?Ile?Thr?Asn?Ala?His?Lys?Val?Val?Val?Leu?Cys?Asp

200 205 210

tcc?acc?aag?atg?ggc?acc?gac?tac?ctc?gtg?agc?ttt?ggc?gca?atc?agc 787

Ser?Thr?Lys?Met?Gly?Thr?Asp?Tyr?Leu?Val?Ser?Phe?Gly?Ala?Ile?Ser

215 220 225

gat?atc?gat?gtg?gtg?gtc?acc?gat?gcg?ggt?gca?cca?gca?agt?ttc?gtt 835

Asp?Ile?Asp?Val?Val?Val?Thr?Asp?Ala?Gly?Ala?Pro?Ala?Ser?Phe?Val

230 235 240 245

gag?cag?ttg?cga?gaa?cgc?gat?gta?gaa?gtt?gtg?att?gca?gaa 877

Glu?Gln?Leu?Arg?Glu?Arg?Asp?Val?Glu?Val?Val?Ile?Ala?Glu

250 255

tgattcttac?agtcactgca?agt 900

<210>194

<211>259

<212>PRT

＜213〉Corynebacterium glutamicum

<400>194

Met?Tyr?Ala?Glu?Glu?Arg?Arg?Arg?Gln?Ile?Ala?Ser?Leu?Thr?Ala?Val

1 5 10 15

Glu?Gly?Arg?Val?Asn?Val?Thr?Glu?Leu?Ala?Gly?Arg?Phe?Asp?Val?Thr

20 25 30

Ala?Glu?Thr?Ile?Arg?Arg?Asp?Leu?Ala?Val?Leu?Asp?Arg?Glu?Gly?Ile

35 40 45

Val?His?Arg?Val?His?Gly?Gly?Ala?Val?Ala?Thr?Gln?Ser?Phe?Gln?Thr

50 55 60

Thr?Glu?Leu?Ser?Leu?Asp?Thr?Arg?Phe?Arg?Ser?Ala?Ser?Ser?Ala?Lys

65 70 75 80

Tyr?Ser?Ile?Ala?Lys?Ala?Ala?Met?Gln?Phe?Leu?Pro?Ala?Glu?His?Gly

85 90 95

Gly?Leu?Phe?Leu?Asp?Ala?Gly?Thr?Thr?Val?Thr?Ala?Leu?Ala?Asp?Leu

100 105 110

Ile?Ser?Glu?His?Pro?Ser?Ser?Lys?Gln?Trp?Ser?Ile?Val?Thr?Asn?Cys

115 120 125

Leu?Pro?Ile?Ala?Leu?Asn?Leu?Ala?Asn?Ala?Gly?Leu?Asp?Asp?Val?Gln

130 135 140

Leu?Leu?Gly?Gly?Ser?Val?Arg?Ala?Ile?Thr?Gln?Ala?Val?Val?Gly?Asp

145 150 155 160

Thr?Ala?Leu?Arg?Thr?Leu?Ala?Leu?Met?Arg?Ala?Asp?Val?Val?Phe?Ile

165 170 175

Gly?Thr?Asn?Ala?Leu?Thr?Leu?Asp?His?Gly?Leu?Ser?Thr?Ala?Asp?Ser

180 185 190

Gln?Glu?Ala?Ala?Met?Lys?Ser?Ala?Met?Ile?Thr?Asn?Ala?His?Lys?Val

195 200 205

Val?Val?Leu?Cys?Asp?Ser?Thr?Lys?Met?Gly?Thr?Asp?Tyr?Leu?Val?Ser

210 215 220

Phe?Gly?Ala?Ile?Ser?Asp?Ile?Asp?Val?Val?Val?Thr?Asp?Ala?Gly?Ala

225 230 235 240

Pro?Ala?Ser?Phe?Val?Glu?Gln?Leu?Arg?Glu?Arg?Asp?Val?Glu?Val?Val

245 250 255

Ile?Ala?Glu

<210>195

<211>969

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(946)

<223>RXA02288

<400>195

aacaacaatc?taacgccatc?atgttataaa?aaagcaagac?ctaacataaa?aatgttagaa?60

agtgctggat?ctaacaacat?ttccgtggta?actttttcac?atg?tcc?caa?gtg?att 115

Met?Ser?Gln?Val?Ile

1 5

ccc?gcc?agc?tca?caa?gaa?aag?cgt?cgt?gag?cgc?atc?gtt?tct?tat?gtc 163

Pro?Ala?Ser?Ser?Gln?Glu?Lys?Arg?Arg?Glu?Arg?Ile?Val?Ser?Tyr?Val

10 15 20

acc?cgt?cat?gga?ttc?gct?cgt?gtt?gaa?gca?tta?gct?gag?ctt?ttt?gag 211

Thr?Arg?His?Gly?Phe?Ala?Arg?Val?Glu?Ala?Leu?Ala?Glu?Leu?Phe?Glu

25 30 35

gtc?agc?gca?atg?acc?att?cac?cgt?gat?ttg?gag?gcg?ctg?gct?gca?gac 259

Val?Ser?Ala?Met?Thr?Ile?His?Arg?Asp?Leu?Glu?Ala?Leu?Ala?Ala?Asp

40 45 50

aat?ttg?gtg?gag?cgc?att?agg?ggt?ggc?gcg?cgt?tcg?gtg?tcg?ccg?tcg 307

Asn?Leu?Val?Glu?Arg?Ile?Arg?Gly?Gly?Ala?Arg?Ser?Val?Ser?Pro?Ser

55 60 65

atg?agt?gag?ttg?gca?gtg?gag?cag?cgt?cgg?cat?ttg?cat?cgc?act?gtt 355

Met?Ser?Glu?Leu?Ala?Val?Glu?Gln?Arg?Arg?His?Leu?His?Arg?Thr?Val

70 75 80 85

aaa?gag?gcg?ttg?tgt?act?gca?gca?gca?cgg?ttg?att?ccg?gag?ggc?gct 403

Lys?Glu?Ala?Leu?Cys?Thr?Ala?Ala?Ala?Arg?Leu?Ile?Pro?Glu?Gly?Ala

90 95 100

gtg?gtg?gcg?att?gat?gat?tcc?acc?acg?ttg?gag?tct?ttg?gtt?gag?aag 451

Val?Val?Ala?Ile?Asp?Asp?Ser?Thr?Thr?Leu?Glu?Ser?Leu?Val?Glu?Lys

105 110 115

ttg?ccg?cag?cgg?tca?cca?tcg?gcg?ttg?att?acg?cat?tct?ttg?aag?aca 499

Leu?Pro?Gln?Arg?Ser?Pro?Ser?Ala?Leu?Ile?Thr?His?Ser?Leu?Lys?Thr

120 125 130

atg?gcg?gat?cat?cgt?gtg?cgc?gcc?ggg?atg?agc?gat?atc?cgt?ttg?att 547

Met?Ala?Asp?His?Arg?Val?Arg?Ala?Gly?Met?Ser?Asp?Ile?Arg?Leu?Ile

135 140 145

gcg?tgt?gcg?gga?ttg?tat?ttc?gcg?gag?act?gat?tct?ttc?ttg?ggc?aag 595

Ala?Cys?Ala?Gly?Leu?Tyr?Phe?Ala?Glu?Thr?Asp?Ser?Phe?Leu?Gly?Lys

150 155 160 165

gca?act?tca?gcg?cag?ttg?aat?gag?ctg?tcg?gcg?gat?att?tct?ttt?gtt 643

Ala?Thr?Ser?Ala?Gln?Leu?Asn?Glu?Leu?Ser?Ala?Asp?Ile?Ser?Phe?Val

170 175 180

tct?acg?act?gcg?gtg?cgc?gct?acg?ggg?gag?gtt?ccg?gcg?ctg?ttt?cat 691

Ser?Thr?Thr?Ala?Val?Arg?Ala?Thr?Gly?Glu?Val?Pro?Ala?Leu?Phe?His

185 190 195

cct?gat?atg?gag?gct?gct?gat?acg?aag?cgg?gcg?ttg?att?ggg?att?ggt 739

Pro?Asp?Met?Glu?Ala?Ala?Asp?Thr?Lys?Arg?Ala?Leu?Ile?Gly?Ile?Gly

200 205 210

agc?gtg?cgt?gtg?ttg?gtg?gtg?gat?tct?agt?aaa?ttt?ggt?tcg?gct?ggt 787

Ser?Val?Arg?Val?Leu?Val?Val?Asp?Ser?Ser?Lys?Phe?Gly?Ser?Ala?Gly

215 220 225

gtg?ttc?aag?gtt?gct?tcg?att?gag?gag?ttt?gac?cac?atc?atc?att?gat 835

Val?Phe?Lys?Val?Ala?Ser?Ile?Glu?Glu?Phe?Asp?His?Ile?Ile?Ile?Asp

230 235 240 245

cag?cag?tgc?acc?cgt?gag?cag?cgg?gat?ctt?ttg?cgt?aat?tcg?cgc?gcg 883

Gln?Gln?Cys?Thr?Arg?Glu?Gln?Arg?Asp?Leu?Leu?Arg?Asn?Ser?Arg?Ala

250 255 260

cag?atc?cat?gtg?att?gac?cac?aat?ggt?gat?gaa?att?ttg?gat?acc?cca 931

Gln?Ile?His?Val?Ile?Asp?His?Asn?Gly?Asp?Glu?Ile?Leu?Asp?Thr?Pro

265 270 275

acg?gaa?gag?gat?ttt?taagatggct?ttggttcttg?gaa 969

Thr?Glu?Glu?Asp?Phe

280

<210>196

<211>282

<212>PRT

＜213〉Corynebacterium glutamicum

<400>196

Met?Ser?Gln?Val?Ile?Pro?Ala?Ser?Ser?Gln?Glu?Lys?Arg?Arg?Glu?Arg

1 5 10 15

Ile?Val?Ser?Tyr?Val?Thr?Arg?His?Gly?Phe?Ala?Arg?Val?Glu?Ala?Leu

20 25 30

Ala?Glu?Leu?Phe?Glu?Val?Ser?Ala?Met?Thr?Ile?His?Arg?Asp?Leu?Glu

35 40 45

Ala?Leu?Ala?Ala?Asp?Asn?Leu?Val?Glu?Arg?Ile?Arg?Gly?Gly?Ala?Arg

50 55 60

Ser?Val?Ser?Pro?Ser?Met?Ser?Glu?Leu?Ala?Val?Glu?Gln?Arg?Arg?His

65 70 75 80

Leu?His?Arg?Thr?Val?Lys?Glu?Ala?Leu?Cys?Thr?Ala?Ala?Ala?Arg?Leu

85 90 95

Ile?Pro?Glu?Gly?Ala?Val?Val?Ala?Ile?Asp?Asp?Ser?Thr?Thr?Leu?Glu

100 105 110

Ser?Leu?Val?Glu?Lys?Leu?Pro?Gln?Arg?Ser?Pro?Ser?Ala?Leu?Ile?Thr

115 120 125

His?Ser?Leu?Lys?Thr?Met?Ala?Asp?His?Arg?Val?Arg?Ala?Gly?Met?Ser

130 135 140

Asp?Ile?Arg?Leu?Ile?Ala?Cys?Ala?Gly?Leu?Tyr?Phe?Ala?Glu?Thr?Asp

145 150 155 160

Ser?Phe?Leu?Gly?Lys?Ala?Thr?Ser?Ala?Gln?Leu?Asn?Glu?Leu?Ser?Ala

165 170 175

Asp?Ile?Ser?Phe?Val?Ser?Thr?Thr?Ala?Val?Arg?Ala?Thr?Gly?Glu?Val

180 185 190

Pro?Ala?Leu?Phe?His?Pro?Asp?Met?Glu?Ala?Ala?Asp?Thr?Lys?Arg?Ala

195 200 205

Leu?Ile?Gly?Ile?Gly?Ser?Val?Arg?Val?Leu?Val?Val?Asp?Ser?Ser?Lys

210 215 220

Phe?Gly?Ser?Ala?Gly?Val?Phe?Lys?Val?Ala?Ser?Ile?Glu?Glu?Phe?Asp

225 230 235 240

His?Ile?Ile?Ile?Asp?Gln?Gln?Cys?Thr?Arg?Glu?Gln?Arg?Asp?Leu?Leu

245 250 255

Arg?Asn?Ser?Arg?Ala?Gln?Ile?His?Val?Ile?Asp?His?Asn?Gly?Asp?Glu

260 265 270

Ile?Leu?Asp?Thr?Pro?Thr?Glu?Glu?Asp?Phe

275 280

<210>197

<211>887

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(864)

<223>RXN01891

<400>197

ggt?ggc?cac?tat?ggt?ttg?cct?ttc?gct?cgc?tcc?act?gtc?ctc?ttc?tac 48

Gly?Gly?His?Tyr?Gly?Leu?Pro?Phe?Ala?Arg?Ser?Thr?Val?Leu?Phe?Tyr

1 5 10 15

tac?aac?aag?gat?ctg?tgg?gct?aag?gct?ggc?ctg?gaa?gat?cgt?ggc?cca 96

Tyr?Asn?Lys?Asp?Leu?Trp?Ala?Lys?Ala?Gly?Leu?Glu?Asp?Arg?Gly?Pro

20 25 30

gag?tca?tgg?gaa?gag?ttc?tcc?gag?tgg?ggt?cca?aag?ctg?cag?gaa?gcg 144

Glu?Ser?Trp?Glu?Glu?Phe?Ser?Glu?Trp?Gly?Pro?Lys?Leu?Gln?Glu?Ala

35 40 45

atg?gac?agt?ggt?ttc?gca?cac?ggt?tgg?gga?gat?gca?acc?aac?tac?ctt 192

Met?Asp?Ser?Gly?Phe?Ala?His?Gly?Trp?Gly?Asp?Ala?Thr?Ash?Tyr?Leu

50 55 60

tct?tgg?act?ttc?gaa?ggc?cca?atg?tgg?tcc?ctc?ggc?ggc?aac?tac?tct 240

Ser?Trp?Thr?Phe?Glu?Gly?Pro?Met?Trp?Ser?Leu?Gly?Gly?Asn?Tyr?Ser

65 70 75 80

gaa?ggt?tgg?gag?tcc?cgt?ctg?act?acc?cca?gag?acc?atc?cgt?gca?gtt 288

Glu?Gly?Trp?Glu?Ser?Arg?Leu?Thr?Thr?Pro?Glu?Thr?Ile?Arg?Ala?Val

85 90 95

gag?tgg?ctc?aag?tcc?acc?gtt?gat?gaa?ggt?ttc?gca?acc?gtc?tcc?acc 336

Glu?Trp?Leu?Lys?Ser?Thr?Val?Asp?Glu?Gly?Phe?Ala?Thr?Val?Ser?Thr

100 105 110

gac?gtc?acc?aac?gag?ttc?gca?acc?ggc?ctg?atc?ggt?tca?tgc?atc?cag 384

Asp?Val?Thr?Asn?Glu?Phe?Ala?Thr?Gly?Leu?Ile?Gly?Ser?Cys?Ile?Gln

115 120 125

tcc?acc?ggt?gat?ctg?tct?tcg?gtt?gcc?ggc?gct?gca?agc?ttc?gac?tgg 432

Ser?Thr?Gly?Asp?Leu?Ser?Ser?Val?Ala?Gly?Ala?Ala?Ser?Phe?Asp?Trp

130 135 140

ggc?gta?gca?gca?ctt?cct?aac?cca?acc?ggc?gag?ggc?gct?tgc?cca?acc 480

Gly?Val?Ala?Ala?Leu?Pro?Asn?Pro?Thr?Gly?Glu?Gly?Ala?Cys?Pro?Thr

145 150 155 160

ggt?ggc?gca?ggc?ctg?gga?atc?cca?tct?ggc?atc?tct?gag?cag?cgt?cag 528

Gly?Gly?Ala?Gly?Leu?Gly?Ile?Pro?Ser?Gly?Ile?Ser?Glu?Gln?Arg?Gln

165 170 175

gac?aac?gcc?ctg?aag?ttc?atc?gac?ttc?ctc?acc?aac?gcc?gcg?aac?act 576

Asp?Asn?Ala?Leu?Lys?Phe?Ile?Asp?Phe?Leu?Thr?Asn?Ala?Ala?Asn?Thr

180 185 190

ggc?tac?tgg?tcc?cgc?gag?acc?ggt?tat?gtt?cca?gtt?cgt?aag?gat?gct 624

Gly?Tyr?Trp?Ser?Arg?Glu?Thr?Gly?Tyr?Val?Pro?Val?Arg?Lys?Asp?Ala

195 200 205

gca?tct?gat?cca?gat?cac?gca?gca?ttc?ctc?gag?gag?aac?cct?gca?tac 672

Ala?Ser?Asp?Pro?Asp?His?Ala?Ala?Phe?Leu?Glu?Glu?Asn?Pro?Ala?Tyr

210 215 220

aac?gtt?gca?gtg?gag?cag?ctt?cct?gat?acc?cgt?tcc?cag?gac?aac?ttc 720

Asn?Val?Ala?Val?Glu?Gln?Leu?Pro?Asp?Thr?Arg?Ser?Gln?Asp?Asn?Phe

225 230 235 240

cgc?gtg?ctg?ctg?cca?aac?ggt?gac?cgc?acc?atc?ggt?gac?gca?ctg?gag 768

Arg?Val?Leu?Leu?Pro?Asn?Gly?Asp?Arg?Thr?Ile?Gly?Asp?Ala?Leu?Glu

245 250 255

aag?atc?tgc?ctg?act?ggt?gca?gac?atc?gat?gtc?acc?ctg?gct?gag?gtt 816

Lys?Ile?Cys?Leu?Thr?Gly?Ala?Asp?Ile?Asp?Val?Thr?Leu?Ala?Glu?Val

260 265 270

gag?acc?aag?ctg?aac?acc?atc?tac?acc?cgc?gac?atc?gaa?cca?ctt?att 864

Glu?Thr?Lys?Leu?Asn?Thr?Ile?Tyr?Thr?Arg?Asp?Ile?Glu?Pro?Leu?Ile

275 280 285

taatccgagc?acttcagcta?cac 887

<210>198

<211>288

<212>PRT

＜213〉Corynebacterium glutamicum

<400>198

Gly?Gly?His?Tyr?Gly?Leu?Pro?Phe?Ala?Arg?Ser?Thr?Val?Leu?Phe?Tyr

1 5 10 15

Tyr?Asn?Lys?Asp?Leu?Trp?Ala?Lys?Ala?Gly?Leu?Glu?Asp?Arg?Gly?Pro

20 25 30

Glu?Ser?Trp?Glu?Glu?Phe?Ser?Glu?Trp?Gly?Pro?Lys?Leu?Gln?Glu?Ala

35 40 45

Met?Asp?Ser?Gly?Phe?Ala?His?Gly?Trp?Gly?Asp?Ala?Thr?Asn?Tyr?Leu

50 55 60

Ser?Trp?Thr?Phe?Glu?Gly?Pro?Met?Trp?Ser?Leu?Gly?Gly?Asn?Tyr?Ser

65 70 75 80

Glu?Gly?Trp?Glu?Ser?Arg?Leu?Thr?Thr?Pro?Glu?Thr?Ile?Arg?Ala?Val

85 90 95

Glu?Trp?Leu?Lys?Ser?Thr?Val?Asp?Glu?Gly?Phe?Ala?Thr?Val?Ser?Thr

100 105 110

Asp?Val?Thr?Asn?Glu?Phe?Ala?Thr?Gly?Leu?Ile?Gly?Ser?Cys?Ile?Gln

115 120 125

Ser?Thr?Gly?Asp?Leu?Ser?Ser?Val?Ala?Gly?Ala?Ala?Ser?Phe?Asp?Trp

130 135 140

Gly?Val?Ala?Ala?Leu?Pro?Asn?Pro?Thr?Gly?Glu?Gly?Ala?Cys?Pro?Thr

145 150 155 160

Gly?Gly?Ala?Gly?Leu?Gly?Ile?Pro?Ser?Gly?Ile?Ser?Glu?Gln?Arg?Gln

165 170 175

Asp?Asn?Ala?Leu?Lys?Phe?Ile?Asp?Phe?Leu?Thr?Asn?Ala?Ala?Asn?Thr

180 185 190

Gly?Tyr?Trp?Ser?Arg?Glu?Thr?Gly?Tyr?Val?Pro?Val?Arg?Lys?Asp?Ala

195 200 205

Ala?Ser?Asp?Pro?Asp?His?Ala?Ala?Phe?Leu?Glu?Glu?Asn?Pro?Ala?Tyr

210 215 220

Asn?Val?Ala?Val?Glu?Gln?Leu?Pro?Asp?Thr?Arg?Ser?Gln?Asp?Asn?Phe

225 230 235 240

Arg?Val?Leu?Leu?Pro?Asn?Gly?Asp?Arg?Thr?Ile?Gly?Asp?Ala?Leu?Glu

245 250 255

Lys?Ile?Cys?Leu?Thr?Gly?Ala?Asp?Ile?Asp?Val?Thr?Leu?Ala?Glu?Val

260 265 270

Glu?Thr?Lys?Leu?Asn?Thr?Ile?Tyr?Thr?Arg?Asp?Ile?Glu?Pro?Leu?Ile

275 280 285

<210>199

<211>842

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(819)

<223>FRXA01891

<400>199

tac?tac?aac?aag?gat?ctg?tgg?gct?aag?gct?ggc?ctg?gaa?gat?cgt?ggc 48

Tyr?Tyr?Asn?Lys?Asp?Leu?Trp?Ala?Lys?Ala?Gly?Leu?Glu?Asp?Arg?Gly

1 5 10 15

cca?gag?tca?tgg?gaa?gag?ttc?tcc?gag?tgg?ggt?cca?aag?ctg?cag?gaa 96

Pro?Glu?Ser?Trp?Glu?Glu?Phe?Ser?Glu?Trp?Gly?Pro?Lys?Leu?Gln?Glu

20 25 30

gcg?atg?gac?agt?ggt?ttc?gca?cac?ggt?tgg?gga?gat?gca?acc?aac?tac 144

Ala?Met?Asp?Ser?Gly?Phe?Ala?His?Gly?Trp?Gly?Asp?Ala?Thr?Asn?Tyr

35 40 45

ctt?tct?tgg?act?ttc?gaa?ggc?cca?atg?tgg?tcc?ctc?ggc?ggc?aac?tac 192

Leu?Ser?Trp?Thr?Phe?Glu?Gly?Pro?Met?Trp?Ser?Leu?Gly?Gly?Asn?Tyr

50 55 60

tct?gaa?ggt?tgg?gag?tcc?cgt?ctg?act?acc?cca?gag?acc?atc?cgt?gca 240

Ser?Glu?Gly?Trp?Glu?Ser?Arg?Leu?Thr?Thr?Pro?Glu?Thr?Ile?Arg?Ala

65 70 75 80

gtt?gag?tgg?ctc?aag?tcc?acc?gtt?gat?gaa?ggt?ttc?gca?acc?gtc?tcc 288

Val?Glu?Trp?Leu?Lys?Ser?Thr?Val?Asp?Glu?Gly?Phe?Ala?Thr?Val?Ser

85 90 95

acc?gac?gtc?acc?aac?gag?ttc?gca?acc?ggc?ctg?atc?ggt?tca?tgc?atc 336

Thr?Asp?Val?Thr?Asn?Glu?Phe?Ala?Thr?Gly?Leu?Ile?Gly?Ser?Cys?Ile

100 105 110

cag?tcc?acc?ggt?gat?ctg?tct?tcg?gtt?gcc?ggc?gct?gca?agc?ttc?gac 384

Gln?Ser?Thr?Gly?Asp?Leu?Ser?Ser?Val?Ala?Gly?Ala?Ala?Ser?Phe?Asp

115 120 125

tgg?ggc?gta?gca?gca?ctt?cct?aac?cca?acc?ggc?gag?ggc?gct?tgc?cca 432

Trp?Gly?Val?Ala?Ala?Leu?Pro?Asn?Pro?Thr?Gly?Glu?Gly?Ala?Cys?Pro

130 135 140

acc?ggt?ggc?gca?ggc?ctg?gga?atc?cca?tct?ggc?atc?tct?gag?cag?cgt 480

Thr?Gly?Gly?Ala?Gly?Leu?Gly?Ile?Pro?Ser?Gly?Ile?Ser?Glu?Gln?Arg

145 150 155 160

cag?gac?aac?gcc?ctg?aag?ttc?atc?gac?ttc?ctc?acc?aac?gcc?gcg?aac 528

Gln?Asp?Asn?Ala?Leu?Lys?Phe?Ile?Asp?Phe?Leu?Thr?Asn?Ala?Ala?Asn

165 170 175

act?ggc?tac?tgg?tcc?cgc?gag?acc?ggt?tat?gtt?cca?gtt?cgt?aag?gat 576

Thr?Gly?Tyr?Trp?Ser?Arg?Glu?Thr?Gly?Tyr?Val?Pro?Val?Arg?Lys?Asp

180 185 190

gct?gca?tct?gat?cca?gat?cac?gca?gca?ttc?ctc?gag?gag?aac?cct?gca 624

Ala?Ala?Ser?Asp?Pro?Asp?His?Ala?Ala?Phe?Leu?Glu?Glu?Asn?Pro?Ala

195 200 205

tac?aac?gtt?gca?gtg?gag?cag?ctt?cct?gat?acc?cgt?tcc?cag?gac?aac 672

Tyr?Asn?Val?Ala?Val?Glu?Gln?Leu?Pro?Asp?Thr?Arg?Ser?Gln?Asp?Asn

210 215 220

ttc?cgc?gtg?ctg?ctg?cca?aac?ggt?gac?cgc?acc?atc?ggt?gac?gca?ctg 720

Phe?Arg?Val?Leu?Leu?Pro?Asn?Gly?Asp?Arg?Thr?Ile?Gly?Asp?Ala?Leu

225 230 235 240

gag?aag?atc?tgc?ctg?act?ggt?gca?gac?atc?gat?gtc?acc?ctg?gct?gag 768

Glu?Lys?Ile?Cys?Leu?Thr?Gly?Ala?Asp?Ile?Asp?Val?Thr?Leu?Ala?Glu

245 250 255

gtt?gag?acc?aag?ctg?aac?acc?atc?tac?acc?cgc?gac?atc?gaa?cca?ctt 816

Val?Glu?Thr?Lys?Leu?Asn?Thr?Ile?Tyr?Thr?Arg?Asp?Ile?Glu?Pro?Leu

260 265 270

att?taatccgagc?acttcagcta?cac 842

Ile

<210>200

<211>273

<212>PRT

＜213〉Corynebacterium glutamicum

<400>200

Tyr?Tyr?Asn?Lys?Asp?Leu?Trp?Ala?Lys?Ala?Gly?Leu?Glu?Asp?Arg?Gly

1 5 10 15

Pro?Glu?Ser?Trp?Glu?Glu?Phe?Ser?Glu?Trp?Gly?Pro?Lys?Leu?Gln?Glu

20 25 30

Ala?Met?Asp?Ser?Gly?Phe?Ala?His?Gly?Trp?Gly?Asp?Ala?Thr?Asn?Tyr

35 40 45

Leu?Ser?Trp?Thr?Phe?Glu?Gly?Pro?Met?Trp?Ser?Leu?Gly?Gly?Asn?Tyr

50 55 60

Ser?Glu?Gly?Trp?Glu?Ser?Arg?Leu?Thr?Thr?Pro?Glu?Thr?Ile?Arg?Ala

65 70 75 80

Val?Glu?Trp?Leu?Lys?Ser?Thr?Val?Asp?Glu?Gly?Phe?Ala?Thr?Val?Ser

85 90 95

Thr?Asp?Val?Thr?Asn?Glu?Phe?Ala?Thr?Gly?Leu?Ile?Gly?Ser?Cys?Ile

100 105 110

Gln?Ser?Thr?Gly?Asp?Leu?Ser?Ser?Val?Ala?Gly?Ala?Ala?Ser?Phe?Asp

115 120 125

Trp?Gly?Val?Ala?Ala?Leu?Pro?Asn?Pro?Thr?Gly?Glu?Gly?Ala?Cys?Pro

130 135 140

Thr?Gly?Gly?Ala?Gly?Leu?Gly?Ile?Pro?Ser?Gly?Ile?Ser?Glu?Gln?Arg

145 150 155 160

Gln?Asp?Asn?Ala?Leu?Lys?Phe?Ile?Asp?Phe?Leu?Thr?Asn?Ala?Ala?Asn

165 170 175

Thr?Gly?Tyr?Trp?Ser?Arg?Glu?Thr?Gly?Tyr?Val?Pro?Val?Arg?Lys?Asp

180 185 190

Ala?Ala?Ser?Asp?Pro?Asp?His?Ala?Ala?Phe?Leu?Glu?Glu?Asn?Pro?Ala

195 200 205

Tyr?Asn?Val?Ala?Val?Glu?Gln?Leu?Pro?Asp?Thr?Arg?Ser?Gln?Asp?Asn

210 215 220

Phe?Arg?Val?Leu?Leu?Pro?Asn?Gly?Asp?Arg?Thr?Ile?Gly?Asp?Ala?Leu

225 230 235 240

Glu?Lys?Ile?Cys?Leu?Thr?Gly?Ala?Asp?Ile?Asp?Val?Thr?Leu?Ala?Glu

245 250 255

Val?Glu?Thr?Lys?Leu?Asn?Thr?Ile?Tyr?Thr?Arg?Asp?Ile?Glu?Pro?Leu

260 265 270

Ile

<210>201

<211>776

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(7)..(753)

<223>RXA02414

<400>201

tttacc?atg?agt?tac?aac?agc?ccg?tat?aac?aac?acg?aat?ttc?agc?acc?act?51

Met?Ser?Tyr?Asn?Ser?Pro?Tyr?Asn?Asn?Thr?Asn?Phe?Ser?Thr?Thr

1 5 10 15

ggc?gcg?ttc?caa?cct?gct?ggt?ggg?ccg?gtg?aag?ccg?tgg?aat?aag?ccc 99

Gly?Ala?Phe?Gln?Pro?Ala?Gly?Gly?Pro?Val?Lys?Pro?Trp?Asn?Lys?Pro

20 25 30

gat?gcc?agc?ctg?aat?cag?cag?ctg?aaa?aac?aaa?tcc?cgt?gtg?cgc?aca 147

Asp?Ala?Ser?Leu?Asn?Gln?Gln?Leu?Lys?Asn?Lys?Ser?Arg?Val?Arg?Thr

35 40 45

ggt?ctt?acc?atc?gcc?atc?ggt?tat?gta?gtg?gtg?att?tgg?gcg?gtg?cat 195

Gly?Leu?Thr?Ile?Ala?Ile?Gly?Tyr?Val?Val?Val?Ile?Trp?Ala?Val?His

50 55 60

ttg?gca?tcc?atc?gtc?att?gcg?ctg?ctc?act?ggc?ttc?aac?ctg?acc?aac 243

Leu?Ala?Ser?Ile?Val?Ile?Ala?Leu?Leu?Thr?Gly?Phe?Asn?Leu?Thr?Asn

65 70 75

ttt?ggt?att?cat?ccg?ctg?gat?acc?agt?gca?ctg?tgg?ggt?att?ttc?acc 291

Phe?Gly?Ile?His?Pro?Leu?Asp?Thr?Ser?Ala?Leu?Trp?Gly?Ile?Phe?Thr

80 85 90 95

tca?ccg?ctg?ttg?cat?gga?agc?ttc?agc?cac?ctc?att?gga?aat?acc?gtt 339

Ser?Pro?Leu?Leu?His?Gly?Ser?Phe?Ser?His?Leu?Ile?Gly?Asn?Thr?Val

100 105 110

cca?ggc?ttt?ata?ttc?agt?ttc?ctc?atc?ggt?atg?agt?ggc?aag?cgc?gtg 387

Pro?Gly?Phe?Ile?Phe?Ser?Phe?Leu?Ile?Gly?Met?Ser?Gly?Lys?Arg?Val

115 120 125

ttc?tgg?gaa?gtc?acg?att?atc?gca?ggt?ctc?atc?ggc?ggt?ctt?ggt?aca 435

Phe?Trp?Glu?Val?Thr?Ile?Ile?Ala?Gly?Leu?Ile?Gly?Gly?Leu?Gly?Thr

130 135 140

tgg?att?ttc?ggt?gga?atc?ggc?acc?aac?cac?atc?ggt?gcg?tcc?ggc?ctg 483

Trp?Ile?Phe?Gly?Gly?Ile?Gly?Thr?Asn?His?Ile?Gly?Ala?Ser?Gly?Leu

145 150 155

att?tat?ggc?tgg?ctt?ggc?tac?ctg?atc?gtg?cgt?gga?att?ttc?aac?aag 531

Ile?Tyr?Gly?Trp?Leu?Gly?Tyr?Leu?Ile?Val?Arg?Gly?Ile?Phe?Asn?Lys

160 165 170 175

gat?att?aaa?cag?ttc?ctg?ctt?ggc?ata?gtt?ttg?gcg?ttc?att?tac?tcc 579

Asp?Ile?Lys?Gln?Phe?Leu?Leu?Gly?Ile?Val?Leu?Ala?Phe?Ile?Tyr?Ser

180 185 190

ggt?ttg?ttc?tgg?ggt?ctg?cta?cct?act?caa?atc?ggt?gtg?tcc?tgg?cag 627

Gly?Leu?Phe?Trp?Gly?Leu?Leu?Pro?Thr?Gln?Ile?Gly?Val?Ser?Trp?Gln

195 200 205

ggc?cac?ctt?ttc?ggt?gca?ctt?ggt?gga?atc?ggt?gcg?ggt?gct?ttt?atc 675

Gly?His?Leu?Phe?Gly?Ala?Leu?Gly?Gly?Ile?Gly?Ala?Gly?Ala?Phe?Ile

210 215 220

gcc?tcg?gat?gac?ccg?gca?gcg?ttg?aaa?gcg?aag?aag?caa?cag?aag?aaa 723

Ala?Ser?Asp?Asp?Pro?Ala?Ala?Leu?Lys?Ala?Lys?Lys?Gln?Gln?Lys?Lys

225 230 235

tta?gaa?aag?caa?caa?cgc?caa?aga?ggc?tta?tagttttcac?ctagcgacta 773

Leu?Glu?Lys?Gln?Gln?Arg?Gln?Arg?Gly?Leu

240 245

cac 776

<210>202

<211>249

<212>PRT

＜213〉Corynebacterium glutamicum

<400>202

Met?Ser?Tyr?Asn?Ser?Pro?Tyr?Asn?Asn?Thr?Asn?Phe?Ser?Thr?Thr?Gly

1 5 10 15

Ala?Phe?Gln?Pro?Ala?Gly?Gly?Pro?Val?Lys?Pro?Trp?Asn?Lys?Pro?Asp

20 25 30

Ala?Ser?Leu?Asn?Gln?Gln?Leu?Lys?Asn?Lys?Ser?Arg?Val?Arg?Thr?Gly

35 40 45

Leu?Thr?Ile?Ala?Ile?Gly?Tyr?Val?Val?Val?Ile?Trp?Ala?Val?His?Leu

50 55 60

Ala?Ser?Ile?Val?Ile?Ala?Leu?Leu?Thr?Gly?Phe?Asn?Leu?Thr?Asn?Phe

65 70 75 80

Gly?Ile?His?Pro?Leu?Asp?Thr?Ser?Ala?Leu?Trp?Gly?Ile?Phe?Thr?Ser

85 90 95

Pro?Leu?Leu?His?Gly?Ser?Phe?Ser?His?Leu?Ile?Gly?Asn?Thr?Val?Pro

100 105 110

Gly?Phe?Ile?Phe?Ser?Phe?Leu?Ile?Gly?Met?Ser?Gly?Lys?Arg?Val?Phe

115 120 125

Trp?Glu?Val?Thr?Ile?Ile?Ala?Gly?Leu?Ile?Gly?Gly?Leu?Gly?Thr?Trp

130 135 140

Ile?Phe?Gly?Gly?Ile?Gly?Thr?Asn?His?Ile?Gly?Ala?Ser?Gly?Leu?Ile

145 150 155 160

Tyr?Gly?Trp?Leu?Gly?Tyr?Leu?Ile?Val?Arg?Gly?Ile?Phe?Asn?Lys?Asp

165 170 175

Ile?Lys?Gln?Phe?Leu?Leu?Gly?Ile?Val?Leu?Ala?Phe?Ile?Tyr?Ser?Gly

180 185 190

Leu?Phe?Trp?Gly?Leu?Leu?Pro?Thr?Gln?Ile?Gly?Val?Ser?Trp?Gln?Gly

195 200 205

His?Leu?Phe?Gly?Ala?Leu?Gly?Gly?Ile?Gly?Ala?Gly?Ala?Phe?Ile?Ala

210 215 220

Ser?Asp?Asp?Pro?Ala?Ala?Leu?Lys?Ala?Lys?Lys?Gln?Gln?Lys?Lys?Leu

225 230 235 240

Glu?Lys?Gln?Gln?Arg?Gln?Arg?Gly?Leu

245

<210>203

<211>840

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(817)

<223>RXN01580

<400>203

cggtaaacgc?ctcattaaag?tccaatgcca?tgctcataac?actaacagtt?aaccgtgcgg?60

tcaactttgc?tccctatcct?taaaaagccc?acagaaaagg?atg?tat?aag?aat?atg 115

Met?Tyr?Lys?Asn?Met

1 5

cac?att?gtt?gcc?cat?cgc?ggt?gcg?gaa?gat?ctg?cac?ctc?gaa?aac?acc 163

His?Ile?Val?Ala?His?Arg?Gly?Ala?Glu?Asp?Leu?His?Leu?Glu?Asn?Thr

10 15 20

atg?acc?gct?ttc?cag?gct?gcc?gcg?ccc?gct?gac?gct?ttt?gag?ctg?gat 211

Met?Thr?Ala?Phe?Gln?Ala?Ala?Ala?Pro?Ala?Asp?Ala?Phe?Glu?Leu?Asp

25 30 35

atc?cac?gcc?acc?gct?gac?aat?cag?gtc?gtc?gtt?atc?cac?gac?cgc?acc 259

Ile?His?Ala?Thr?Ala?Asp?Asn?Gln?Val?Val?Val?Ile?His?Asp?Arg?Thr

40 45 50

gca?gcg?cgt?gtt?gcc?gcg?cca?gat?tcc?ctg?cac?cgc?gac?acc?ccg?gtt 307

Ala?Ala?Arg?Val?Ala?Ala?Pro?Asp?Ser?Leu?His?Arg?Asp?Thr?Pro?Val

55 60 65

gcg?cgc?tta?agc?gcc?gcg?caa?atc?aag?gag?ata?acg?ctt?atc?gac?gga 355

Ala?Arg?Leu?Ser?Ala?Ala?Gln?Ile?Lys?Glu?Ile?Thr?Leu?Ile?Asp?Gly

70 75 80 85

tcc?ccc?gta?cca?acc?ctg?gag?gaa?gtt?cta?ctc?cag?acg?agc?ctg?ccg 403

Ser?Pro?Val?Pro?Thr?Leu?Glu?Glu?Val?Leu?Leu?Gln?Thr?Ser?Leu?Pro

90 95 100

atc?caa?gtg?gaa?atc?aaa?tct?gcc?ggt?gca?gtt?cca?gca?gcc?gca?gca 451

Ile?Gln?Val?Glu?Ile?Lys?Ser?Ala?Gly?Ala?Val?Pro?Ala?Ala?Ala?Ala

105 110 115

tta?ttg?cag?aaa?tac?cca?gag?cac?ctg?gag?cgc?ctg?ctg?ttc?atc?agt 499

Leu?Leu?Gln?Lys?Tyr?Pro?Glu?His?Leu?Glu?Arg?Leu?Leu?Phe?Ile?Ser

120 125 130

ttc?atc?gat?gca?gca?ctg?gtg?gaa?atc?gtg?gat?cga?ctg?cca?gaa?gct 547

Phe?Ile?Asp?Ala?Ala?Leu?Val?Glu?Ile?Val?Asp?Arg?Leu?Pro?Glu?Ala

135 140 145

cgc?gtg?gga?atc?ttg?cgc?gat?gcg?tcc?atg?gat?gat?ctg?cgc?att?ctt 595

Arg?Val?Gly?Ile?Leu?Arg?Asp?Ala?Ser?Met?Asp?Asp?Leu?Arg?Ile?Leu

150 155 160 165

gat?tac?atc?ccg?cta?aaa?aat?gtg?ggc?gcg?atc?ttg?ccc?tcg?tgg?aaa 643

Asp?Tyr?Ile?Pro?Leu?Lys?Asn?Val?Gly?Ala?Ile?Leu?Pro?Ser?Trp?Lys

170 175 180

gca?cta?aac?gtg?gcg?tca?att?gct?gat?cta?cat?acc?aag?gga?atc?aag 691

Ala?Leu?Asn?Val?Ala?Ser?Ile?Ala?Asp?Leu?His?Thr?Lys?Gly?Ile?Lys

185 190 195

gtt?ggc?tgc?tgg?aca?att?cgg?gat?gaa?aat?gcg?ttt?ggg?atc?gca?caa 739

Val?Gly?Cys?Trp?Thr?Ile?Arg?Asp?Glu?Asn?Ala?Phe?Gly?Ile?Ala?Gln

200 205 210

caa?gct?ggc?gtt?gat?tac?gcc?act?gtt?agc?gat?ccc?tct?cgt?ttc?ctc 787

Gln?Ala?Gly?Val?Asp?Tyr?Ala?Thr?Val?Ser?Asp?Pro?Ser?Arg?Phe?Leu

215 220 225

gcg?ccc?tcc?cct?gct?ggg?gag?ttg?cac?tgg?taaataatct?agtgaccaga 837

Ala?Pro?Ser?Pro?Ala?Gly?Glu?Leu?His?Trp

230 235

ctg 840

<210>204

<211>239

<212>PRT

＜213〉Corynebacterium glutamicum

<400>204

Met?Tyr?Lys?Asn?Met?His?Ile?Val?Ala?His?Arg?Gly?Ala?Glu?Asp?Leu

1 5 10 15

His?Leu?Glu?Asn?Thr?Met?Thr?Ala?Phe?Gln?Ala?Ala?Ala?Pro?Ala?Asp

20 25 30

Ala?Phe?Glu?Leu?Asp?Ile?His?Ala?Thr?Ala?Asp?Asn?Gln?Val?Val?Val

35 40 45

Ile?His?Asp?Arg?Thr?Ala?Ala?Arg?Val?Ala?Ala?Pro?Asp?Ser?Leu?His

50 55 60

Arg?Asp?Thr?Pro?Val?Ala?Arg?Leu?Ser?Ala?Ala?Gln?Ile?Lys?Glu?Ile

65 70 75 80

Thr?Leu?Ile?Asp?Gly?Ser?Pro?Val?Pro?Thr?Leu?Glu?Glu?Val?Leu?Leu

85 90 95

Gln?Thr?Ser?Leu?Pro?Ile?Gln?Val?Glu?Ile?Lys?Ser?Ala?Gly?Ala?Val

100 105 110

Pro?Ala?Ala?Ala?Ala?Leu?Leu?Gln?Lys?Tyr?Pro?Glu?His?Leu?Glu?Arg

115 120 125

Leu?Leu?Phe?Ile?Ser?Phe?Ile?Asp?Ala?Ala?Leu?Val?Glu?Ile?Val?Asp

130 135 140

Arg?Leu?Pro?Glu?Ala?Arg?Val?Gly?Ile?Leu?Arg?Asp?Ala?Ser?Met?Asp

145 150 155 160

Asp?Leu?Arg?Ile?Leu?Asp?Tyr?Ile?Pro?Leu?Lys?Asn?Val?Gly?Ala?Ile

165 170 175

Leu?Pro?Ser?Trp?Lys?Ala?Leu?Asn?Val?Ala?Ser?Ile?Ala?Asp?Leu?His

180 185 190

Thr?Lys?Gly?Ile?Lys?Val?Gly?Cys?Trp?Thr?Ile?Arg?Asp?Glu?Asn?Ala

195 200 205

Phe?Gly?Ile?Ala?Gln?Gln?Ala?Gly?Val?Asp?Tyr?Ala?Thr?Val?Ser?Asp

210 215 220

Pro?Ser?Arg?Phe?Leu?Ala?Pro?Ser?Pro?Ala?Gly?Glu?Leu?His?Trp

225 230 235

<210>205

<211>1314

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1291)

<223>RXA01436

<400>205

gcctaaacaa?accagtcaac?gacctttccc?gtggcgcaac?agtccctgac?atcgtcaaca?60

cagtagccat?cacagcaatt?caggcaggag?gacgcagcta?atg?gca?ttg?gca?ctt 115

Met?Ala?Leu?Ala?Leu

1 5

gtt?ttg?aac?tcc?ggt?tca?tct?tcc?atc?aaa?ttc?cag?ctg?gtc?aac?ccc 163

Val?Leu?Asn?Ser?Gly?Ser?Ser?Ser?Ile?Lys?Phe?Gln?Leu?Val?Asn?Pro

10 15 20

gaa?aac?tct?gcc?atc?gac?gag?cca?tat?gtt?tct?ggt?ctt?gtg?gag?cag 211

Glu?Asn?Ser?Ala?Ile?Asp?Glu?Pro?Tyr?Val?Ser?Gly?Leu?Val?Glu?Gln

25 30 35

att?ggt?gag?cca?aac?ggc?cgc?atc?gta?ctc?aaa?ata?gag?ggt?gaa?aaa 259

Ile?Gly?Glu?Pro?Asn?Gly?Arg?Ile?Val?Leu?Lys?Ile?Glu?Gly?Glu?Lys

40 45 50

tat?acc?cta?gag?aca?ccc?atc?gca?gat?cac?tcc?gaa?ggc?cta?aac?ctg 307

Tyr?Thr?Leu?Glu?Thr?Pro?Ile?Ala?Asp?His?Ser?Glu?Gly?Leu?Asn?Leu

55 60 65

gcg?ttc?gat?ctc?atg?gac?cag?cac?aac?tgt?ggt?cct?tcc?caa?ctg?gaa 355

Ala?Phe?Asp?Leu?Met?Asp?Gln?His?Asn?Cys?Gly?Pro?Ser?Gln?Leu?Glu

70 75 80 85

atc?acc?gca?gtt?gga?cac?cgc?gtg?gtc?cac?ggc?gga?atc?ttg?ttc?tcc 403

Ile?Thr?Ala?Val?Gly?His?Arg?Val?Val?His?Gly?Gly?Ile?Leu?Phe?Ser

90 95 100

gca?ccg?gaa?ctt?atc?act?gat?gaa?atc?gtg?gaa?atg?atc?cgc?gat?ctc 451

Ala?Pro?Glu?Leu?Ile?Thr?Asp?Glu?Ile?Val?Glu?Met?Ile?Arg?Asp?Leu

105 110 115

att?cca?ctc?gca?cca?ctg?cac?aac?cct?gca?aac?gtt?gac?ggc?att?gat 499

Ile?Pro?Leu?Ala?Pro?Leu?His?Asn?Pro?Ala?Asn?Val?Asp?Gly?Ile?Asp

120 125 130

gtt?gct?cga?aaa?att?ctc?ccc?gat?gtc?cca?cac?gta?gct?gtc?ttt?gac 547

Val?Ala?Arg?Lys?Ile?Leu?Pro?Asp?Val?Pro?His?Val?Ala?Val?Phe?Asp

135 140 145

acc?ggt?ttc?ttc?cac?tca?ctt?cca?cca?gca?gct?gcg?ctg?tat?gcc?atc 595

Thr?Gly?Phe?Phe?His?Ser?Leu?Pro?Pro?Ala?Ala?Ala?Leu?Tyr?Ala?Ile

150 155 160 165

aac?aag?gat?gtc?gca?gct?gaa?cac?gga?atc?agg?cgc?tat?ggt?ttc?cac 643

Asn?Lys?Asp?Val?Ala?Ala?Glu?His?Gly?Ile?Arg?Arg?Tyr?Gly?Phe?His

170 175 180

ggc?acc?tcc?cat?gaa?ttt?gtg?tcc?aag?cgc?gtg?gtg?gaa?att?ctg?gaa 691

Gly?Thr?Ser?His?Glu?Phe?Val?Ser?Lys?Arg?Val?Val?Glu?Ile?Leu?Glu

185 190 195

aag?ccc?acc?gaa?gac?atc?aac?acc?atc?acc?ttc?cac?ctg?ggc?aac?ggc 739

Lys?Pro?Thr?Glu?Asp?Ile?Asn?Thr?Ile?Thr?Phe?His?Leu?Gly?Asn?Gly

200 205 210

gca?tcc?atg?gct?gct?gtt?caa?ggt?ggc?cgt?gcg?gta?gat?act?tcc?atg 787

Ala?Ser?Met?Ala?Ala?Val?Gln?Gly?Gly?Arg?Ala?Val?Asp?Thr?Ser?Met

215 220 225

ggt?atg?aca?cct?ctc?gcg?ggc?ctt?gtc?atg?ggt?acc?cga?agc?ggt?gac 835

Gly?Met?Thr?Pro?Leu?Ala?Gly?Leu?Val?Met?Gly?Thr?Arg?Ser?Gly?Asp

230 235 240 245

att?gat?cca?ggt?atc?gtc?ttc?cac?ctt?tcc?cgc?acc?gct?ggc?atg?agc 883

Ile?Asp?Pro?Gly?Ile?Val?Phe?His?Leu?Ser?Arg?Thr?Ala?Gly?Met?Ser

250 255 260

atc?gat?gag?atc?gat?aat?ctg?ctg?aac?aaa?aag?tcg?ggt?gta?aag?gga 931

Ile?Asp?Glu?Ile?Asp?Asn?Leu?Leu?Asn?Lys?Lys?Ser?Gly?Val?Lys?Gly

265 270 275

ctt?tcc?ggt?gtt?aat?gat?ttc?cgt?gaa?ctg?cgg?gaa?atg?atc?gac?aac 979

Leu?Ser?Gly?Val?Asn?Asp?Phe?Arg?Glu?Leu?Arg?Glu?Met?Ile?Asp?Asn

280 285 290

aat?gat?caa?gat?gcc?tgg?tcc?gcg?tac?aac?att?tac?ata?cac?caa?ctc 1027

Asn?Asp?Gln?Asp?Ala?Trp?Ser?Ala?Tyr?Asn?Ile?Tyr?Ile?His?Gln?Leu

295 300 305

cgc?cgc?tac?ctc?ggt?tcc?tac?atg?gtg?gca?ctg?gga?cgg?gta?gac?acc 1075

Arg?Arg?Tyr?Leu?Gly?Ser?Tyr?Met?Val?Ala?Leu?Gly?Arg?Val?Asp?Thr

310 315 320 325

atc?gtg?ttc?acc?gcc?ggt?gtc?ggt?gaa?aat?gcc?cag?ttt?gtc?cgt?gag 1123

Ile?Val?Phe?Thr?Ala?Gly?Val?Gly?Glu?Asn?Ala?Gln?Phe?Val?Arg?Glu

330 335 340

gat?gcc?ttg?gca?ggt?ttg?gaa?atg?tac?gga?att?gag?atc?gat?cca?gag 1171

Asp?Ala?Leu?Ala?Gly?Leu?Glu?Met?Tyr?Gly?Ile?Glu?Ile?Asp?Pro?Glu

345 350 355

cgt?aac?gca?ttg?cca?aac?gat?ggt?cct?cga?ttg?att?tcc?acc?gat?gcc 1219

Arg?Asn?Ala?Leu?Pro?Asn?Asp?Gly?Pro?Arg?Leu?Ile?Ser?Thr?Asp?Ala

360 365 370

tcc?aag?gtg?aag?gtg?ttt?gtt?att?cca?act?aat?gaa?gag?tta?gct?atc 1267

Ser?Lys?Val?Lys?Val?Phe?Val?Ile?Pro?Thr?Asn?Glu?Glu?Leu?Ala?Ile

375 380 385

gct?agg?tac?gcg?gtg?aag?ttc?gct?tagctctcct?ggttaggatc?cac 1314

Ala?Arg?Tyr?Ala?Val?Lys?Phe?Ala

390 395

<210>206

<211>397

<212>PRT

＜213〉Corynebacterium glutamicum

<400>206

Met?Ala?Leu?Ala?Leu?Val?Leu?Asn?Ser?Gly?Ser?Ser?Ser?Ile?Lys?Phe

1 5 10 15

Gln?Leu?Val?Asn?Pro?Glu?Asn?Ser?Ala?Ile?Asp?Glu?Pro?Tyr?Val?Ser

20 25 30

Gly?Leu?Val?Glu?Gln?Ile?Gly?Glu?Pro?Asn?Gly?Arg?Ile?Val?Leu?Lys

35 40 45

Ile?Glu?Gly?Glu?Lys?Tyr?Thr?Leu?Glu?Thr?Pro?Ile?Ala?Asp?His?Ser

50 55 60

Glu?Gly?Leu?Asn?Leu?Ala?Phe?Asp?Leu?Met?Asp?Gln?His?Asn?Cys?Gly

65 70 75 80

Pro?Ser?Gln?Leu?Glu?Ile?Thr?Ala?Val?Gly?His?Arg?Val?Val?His?Gly

85 90 95

Gly?Ile?Leu?Phe?Ser?Ala?Pro?Glu?Leu?Ile?Thr?Asp?Glu?Ile?Val?Glu

100 105 110

Met?Ile?Arg?Asp?Leu?Ile?Pro?Leu?Ala?Pro?Leu?His?Asn?Pro?Ala?Ash

115 120 125

Val?Asp?Gly?Ile?Asp?Val?Ala?Arg?Lys?Ile?Leu?Pro?Asp?Val?Pro?His

130 135 140

Val?Ala?Val?Phe?Asp?Thr?Gly?Phe?Phe?His?Ser?Leu?Pro?Pro?Ala?Ala

145 150 155 160

Ala?Leu?Tyr?Ala?Ile?Asn?Lys?Asp?Val?Ala?Ala?Glu?His?Gly?Ile?Arg

165 170 175

Arg?Tyr?Gly?Phe?His?Gly?Thr?Ser?His?Glu?Phe?Val?Ser?Lys?Arg?Val

180 185 190

Val?Glu?Ile?Leu?Glu?Lys?Pro?Thr?Glu?Asp?Ile?Asn?Thr?Ile?Thr?Phe

195 200 205

His?Leu?Gly?Asn?Gly?Ala?Ser?Met?Ala?Ala?Val?Gln?Gly?Gly?Arg?Ala

210 215 220

Val?Asp?Thr?Ser?Met?Gly?Met?Thr?Pro?Leu?Ala?Gly?Leu?Val?Met?Gly

225 230 235 240

Thr?Arg?Ser?Gly?Asp?Ile?Asp?Pro?Gly?Ile?Val?Phe?His?Leu?Ser?Arg

245 250 255

Thr?Ala?Gly?Met?Ser?Ile?Asp?Glu?Ile?Asp?Asn?Leu?Leu?Asn?Lys?Lys

260 265 270

Ser?Gly?Val?Lys?Gly?Leu?Ser?Gly?Val?Asn?Asp?Phe?Arg?Glu?Leu?Arg

275 280 285

Glu?Met?Ile?Asp?Asn?Asn?Asp?Gln?Asp?Ala?Trp?Ser?Ala?Tyr?Asn?Ile

290 295 300

Tyr?Ile?His?Gln?Leu?Arg?Arg?Tyr?Leu?Gly?Ser?Tyr?Met?Val?Ala?Leu

305 310 315 320

Gly?Arg?Val?Asp?Thr?Ile?Val?Phe?Thr?Ala?Gly?Val?Gly?Glu?Asn?Ala

325 330 335

Gln?Phe?Val?Arg?Glu?Asp?Ala?Leu?Ala?Gly?Leu?Glu?Met?Tyr?Gly?Ile

340 345 350

Glu?Ile?Asp?Pro?Glu?Arg?Asn?Ala?Leu?Pro?Asn?Asp?Gly?Pro?Arg?Leu

355 360 365

Ile?Ser?Thr?Asp?Ala?Ser?Lys?Val?Lys?Val?Phe?Val?Ile?Pro?Thr?Asn

370 375 380

Glu?Glu?Leu?Ala?Ile?Ala?Arg?Tyr?Ala?Val?Lys?Phe?Ala

385 390 395

<210>207

<211>927

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(904)

<223>RXA00686

<400>207

ataggcttga?acaatacgtc?gttacactgg?ccgatttgat?acctttcaaa?acttttaccc?60

ttcatcggag?tgccagggga?acttagagga?gcattaaata?atg?gcg?gga?gga?aat 115

Met?Ala?Gly?Gly?Asn

1 5

cgc?gaa?cct?gga?cgt?aca?gtc?acc?tcc?aag?gtg?atc?gcc?gta?ctg?gga 163

Arg?Glu?Pro?Gly?Arg?Thr?Val?Thr?Ser?Lys?Val?Ile?Ala?Val?Leu?Gly

10 15 20

gct?ttt?gaa?cac?acc?atg?cgt?cca?ctt?ggt?gtc?act?gaa?atc?gct?gag 211

Ala?Phe?Glu?His?Thr?Met?Arg?Pro?Leu?Gly?Val?Thr?Glu?Ile?Ala?Glu

25 30 35

ctg?gca?gac?ctc?cca?cca?agt?acc?acc?cac?cgt?ctc?gtt?tct?gaa?tta 259

Leu?Ala?Asp?Leu?Pro?Pro?Ser?Thr?Thr?His?Arg?Leu?Val?Ser?Glu?Leu

40 45 50

acc?gaa?ggc?gga?cta?ctc?agc?aag?aaa?tct?gat?ggg?cgc?tac?caa?ttg 307

Thr?Glu?Gly?Gly?Leu?Leu?Ser?Lys?Lys?Ser?Asp?Gly?Arg?Tyr?Gln?Leu

55 60 65

ggc?tta?cgt?atc?tgg?gaa?ctc?gcc?caa?aat?aca?gga?cgg?cag?tta?cgc 355

Gly?Leu?Arg?Ile?Trp?Glu?Leu?Ala?Gln?Asn?Thr?Gly?Arg?Gln?Leu?Arg

70 75 80 85

gac?act?gca?cgc?ccg?ttc?atc?caa?gag?ctc?tac?tca?ctt?act?tcc?gag 403

Asp?Thr?Ala?Arg?Pro?Phe?Ile?Gln?Glu?Leu?Tyr?Ser?Leu?Thr?Ser?Glu

90 95 100

act?gcg?cag?cta?gtg?gtc?cgc?gat?aaa?gat?gaa?gca?ctt?ttg?att?gac 451

Thr?Ala?Gln?Leu?Val?Val?Arg?Asp?Lys?Asp?Glu?Ala?Leu?Leu?Ile?Asp

105 110 115

cga?gcc?tac?ggc?acg?aag?aaa?att?cca?cgc?tcg?gct?cga?gtc?ggt?ggt 499

Arg?Ala?Tyr?Gly?Thr?Lys?Lys?Ile?Pro?Arg?Ser?Ala?Arg?Val?Gly?Gly

120 125 130

cga?cta?cct?ctg?aac?tcc?act?gcg?gtt?ggc?aag?att?ctc?ctt?gcg?ttt 547

Arg?Leu?Pro?Leu?Asn?Ser?Thr?Ala?Val?Gly?Lys?Ile?Leu?Leu?Ala?Phe

135 140 145

gat?gag?cca?tgg?gta?aaa?cag?tcc?tat?ctc?aag?ctg?cca?ctc?aac?gcc 595

Asp?Glu?Pro?Trp?Val?Lys?Gln?Ser?Tyr?Leu?Lys?Leu?Pro?Leu?Asn?Ala

150 155 160 165

tcc?acc?cca?aag?aca?att?gtg?aat?ccc?gac?gtc?ttg?gct?gcg?cag?ctg 643

Ser?Thr?Pro?Lys?Thr?Ile?Val?Asn?Pro?Asp?Val?Leu?Ala?Ala?Gln?Leu

170 175 180

aaa?caa?att?cac?tcg?caa?ggc?ttt?gcc?atc?aca?cat?gac?gag?caa?cga 691

Lys?Gln?Ile?His?Ser?Gln?Gly?Phe?Ala?Ile?Thr?His?Asp?Glu?Gln?Arg

185 190 195

atc?ggc?ggc?gca?tcg?atc?gcc?gta?ccg?gtc?tgg?cat?aca?gga?aaa?ctg 739

Ile?Gly?Gly?Ala?Ser?Ile?Ala?Val?Pro?Val?Trp?His?Thr?Gly?Lys?Leu

200 205 210

gga?gca?gca?ctg?ggg?ttg?gtg?gtt?ccc?acc?gca?cag?gct?gca?aat?ctt 787

Gly?Ala?Ala?Leu?Gly?Leu?Val?Val?Pro?Thr?Ala?Gln?Ala?Ala?Asn?Leu

215 220 225

gag?cgc?tat?ctc?ccg?atc?ctt?cag?gcg?aca?agt?cag?aga?att?aca?aaa 835

Glu?Arg?Tyr?Leu?Pro?Ile?Leu?Gln?Ala?Thr?Ser?Gln?Arg?Ile?Thr?Lys

230 235 240 245

gca?acc?gcg?ctc?att?cct?ttg?gac?aca?ctt?ttg?gct?tca?cac?aaa?aat 883

Ala?Thr?Ala?Leu?Ile?Pro?Leu?Asp?Thr?Leu?Leu?Ala?Ser?His?Lys?Asn

250 255 260

gca?gaa?cga?aaa?ggc?gat?acc?taaacccgcc?ctccatctgc?ata 927

Ala?Glu?Arg?Lys?Gly?Asp?Thr

265

<210>208

<211>268

<212>PRT

＜213〉Corynebacterium glutamicum

<400>208

Met?Ala?Gly?Gly?Asn?Arg?Glu?Pro?Gly?Arg?Thr?Val?Thr?Ser?Lys?Val

1 5 10 15

Ile?Ala?Val?Leu?Gly?Ala?Phe?Glu?His?Thr?Met?Arg?Pro?Leu?Gly?Val

20 25 30

Thr?Glu?Ile?Ala?Glu?Leu?Ala?Asp?Leu?Pro?Pro?Ser?Thr?Thr?His?Arg

35 40 45

Leu?Val?Ser?Glu?Leu?Thr?Glu?Gly?Gly?Leu?Leu?Ser?Lys?Lys?Ser?Asp

50 55 60

Gly?Arg?Tyr?Gln?Leu?Gly?Leu?Arg?Ile?Trp?Glu?Leu?Ala?Gln?Asn?Thr

65 70 75 80

Gly?Arg?Gln?Leu?Arg?Asp?Thr?Ala?Arg?Pro?Phe?Ile?Gln?Glu?Leu?Tyr

85 90 95

Ser?Leu?Thr?Ser?Glu?Thr?Ala?Gln?Leu?Val?Val?Arg?Asp?Lys?Asp?Glu

100 105 110

Ala?Leu?Leu?Ile?Asp?Arg?Ala?Tyr?Gly?Thr?Lys?Lys?Ile?Pro?Arg?Ser

115 120 125

Ala?Arg?Val?Gly?Gly?Arg?Leu?Pro?Leu?Asn?Ser?Thr?Ala?Val?Gly?Lys

130 135 140

Ile?Leu?Leu?Ala?Phe?Asp?Glu?Pro?Trp?Val?Lys?Gln?Ser?Tyr?Leu?Lys

145 150 155 160

Leu?Pro?Leu?Asn?Ala?Ser?Thr?Pro?Lys?Thr?Ile?Val?Asn?Pro?Asp?Val

165 170 175

Leu?Ala?Ala?Gln?Leu?Lys?Gln?Ile?His?Ser?Gln?Gly?Phe?Ala?Ile?Thr

180 185 190

His?Asp?Glu?Gln?Arg?Ile?Gly?Gly?Ala?Ser?Ile?Ala?Val?Pro?Val?Trp

195 200 205

His?Thr?Gly?Lys?Leu?Gly?Ala?Ala?Leu?Gly?Leu?Val?Val?Pro?Thr?Ala

210 215 220

Gln?Ala?Ala?Asn?Leu?Glu?Arg?Tyr?Leu?Pro?Ile?Leu?Gln?Ala?Thr?Ser

225 230 235 240

G1n?Arg?Ile?Thr?Lys?Ala?Thr?Ala?Leu?Ile?Pro?Leu?Asp?Thr?Leu?Leu

245 250 255

Ala?Ser?His?Lys?Asn?Ala?Glu?Arg?Lys?Gly?Asp?Thr

260 265

<210>209

<211>1158

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..?(1135)

<223>RXA00246

<400>209

ttgcaaggat?tgtaatttaa?ggcacatcta?tgtcggtgtg?aaattacatg?tgccagaaga?60

gcaatttgcc?aagtaatcca?agcgagaagg?agtgagtttt?atg?acc?act?gct?gca 115

Met?Thr?Thr?Ala?Ala

1 5

ccc?caa?gaa?ttt?acc?gct?gct?gtt?gtt?gaa?aaa?ttc?ggt?cat?gac?gtg 163

Pro?Gln?Glu?Phe?Thr?Ala?Ala?Val?Val?Glu?Lys?Phe?Gly?His?Asp?Val

10 15 20

acc?gtg?aag?gat?att?gac?ctt?cca?aag?cca?ggg?cca?cac?cag?gca?ttg 211

Thr?Val?Lys?Asp?Ile?Asp?Leu?Pro?Lys?Pro?Gly?Pro?His?Gln?Ala?Leu

25 30 35

gtg?aag?gta?ctc?acc?tcc?ggc?atc?tgc?cac?acc?gac?ctc?cac?gcc?ttg 259

Val?Lys?Val?Leu?Thr?Ser?Gly?Ile?Cys?His?Thr?Asp?Leu?His?Ala?Leu

40 45 50

gag?ggc?gat?tgg?cca?gta?aag?ccg?gaa?cca?cca?ttc?gta?cca?gga?cac 307

Glu?Gly?Asp?Trp?Pro?Val?Lys?Pro?Glu?Pro?Pro?Phe?Val?Pro?Gly?His

55 60 65

gaa?ggt?gta?ggt?gaa?gtt?gtt?gag?ctc?gga?cca?ggt?gaa?cac?gat?gtg 355

Glu?Gly?Val?Gly?Glu?Val?Val?Glu?Leu?Gly?Pro?Gly?Glu?His?Asp?Val

70 75 80 85

aag?gtc?ggc?gat?att?gtc?ggc?aat?gcg?tgg?ctc?tgg?tca?gcg?tgt?ggc 403

Lys?Val?Gly?Asp?Ile?Val?Gly?Asn?Ala?Trp?Leu?Trp?Ser?Ala?Cys?Gly

90 95 100

acc?tgc?gaa?tac?tgc?atc?acc?ggc?agg?gaa?act?cag?tgc?aac?gaa?gct 451

Thr?Cys?Glu?Tyr?Cys?Ile?Thr?Gly?Arg?Glu?Thr?Gln?Cys?Asn?Glu?Ala

105 110 115

gag?tat?ggt?ggc?tac?acc?caa?aat?gga?tcc?ttc?ggc?cag?tac?atg?ctg 499

Glu?Tyr?Gly?Gly?Tyr?Thr?Gln?Asn?Gly?Ser?Phe?Gly?Gln?Tyr?Met?Leu

120 125 130

gtg?gat?acc?cgt?tac?gcc?gct?cgc?atc?cca?gac?ggc?gtg?gac?tac?ctc 547

Val?Asp?Thr?Arg?Tyr?Ala?Ala?Arg?Ile?Pro?Asp?Gly?Val?Asp?Tyr?Leu

135 140 145

gaa?gca?gca?cca?att?ctg?tgt?gca?ggc?gtg?act?gtc?tac?aag?gca?ctc 595

Glu?Ala?Ala?Pro?Ile?Leu?Cys?Ala?Gly?Val?Thr?Val?Tyr?Lys?Ala?Leu

150 155 160 165

aaa?gtc?tct?gaa?acc?cgc?ccg?ggc?caa?ttc?atg?gtg?atc?tcc?ggt?gtc 643

Lys?Val?Ser?Glu?Thr?Arg?Pro?Gly?Gln?Phe?Met?Val?Ile?Ser?Gly?Val

170 175 180

ggc?gga?ctt?ggc?cac?atc?gca?gtc?caa?tac?gca?gcg?gcg?atg?ggc?atg 691

Gly?Gly?Leu?Gly?His?Ile?Ala?Val?Gln?Tyr?Ala?Ala?Ala?Met?Gly?Met

185 190 195

cgt?gtc?att?gcg?gta?gat?att?gcc?gat?gac?aag?ctg?gaa?ctt?gcc?cgt 739

Arg?Val?Ile?Ala?Val?Asp?Ile?Ala?Asp?Asp?Lys?Leu?Glu?Leu?Ala?Arg

200 205 210

aag?cac?ggt?gcg?gaa?ttt?acc?gtg?aat?gcg?cgt?aat?gaa?gat?tca?ggc 787

Lys?His?Gly?Ala?Glu?Phe?Thr?Val?Asn?Ala?Arg?Asn?Glu?Asp?Ser?Gly

215 220 225

gaa?gct?gta?cag?aag?tac?acc?aac?ggt?ggc?gca?cac?ggc?gtg?ctt?gtg 835

Glu?Ala?Val?Gln?Lys?Tyr?Thr?Asn?Gly?Gly?Ala?His?Gly?Val?Leu?Val

230 235 240 245

act?gca?gtt?cac?gag?gca?gca?ttc?ggc?cag?gca?ctg?gat?atg?gct?cga 883

Thr?Ala?Val?His?Glu?Ala?Ala?Phe?Gly?Gln?Ala?Leu?Asp?Met?Ala?Arg

250 255 260

cgt?gca?gga?aca?att?gtg?ttc?aac?ggt?ctg?cca?ccg?gga?gag?ttc?cca 931

Arg?Ala?Gly?Thr?Ile?Val?Phe?Asn?Gly?Leu?Pro?Pro?Gly?Glu?Phe?Pro

265 270 275

gca?tcc?gtg?ttc?aac?atc?gta?ttc?aag?ggc?ctg?acc?atc?cgt?gga?tcc 979

Ala?Ser?Val?Phe?Asn?Ile?Val?Phe?Lys?Gly?Leu?Thr?Ile?Arg?Gly?Ser

280 285 290

ctc?gtg?gga?acc?cgc?caa?gac?ttg?gcc?gaa?gcg?ctc?gat?ttc?ttt?gca 1027

Leu?Val?Gly?Thr?Arg?Gln?Asp?Leu?Ala?Glu?Ala?Leu?Asp?Phe?Phe?Ala

295 300 305

cgc?gga?cta?atc?aag?cca?acc?gtg?agt?gag?tgc?tcc?ctc?gat?gag?gtc 1075

Arg?Gly?Leu?Ile?Lys?Pro?Thr?Val?Ser?Glu?Cys?Ser?Leu?Asp?Glu?Val

310 315 320 325

aat?ggt?gtg?ctt?gac?cgc?atg?cga?aac?ggc?aag?atc?gat?ggt?cgt?gtg 1123

Asn?Gly?Val?Leu?Asp?Arg?Met?Arg?Asn?Gly?Lys?Ile?Asp?Gly?Arg?Val

330 335 340

gcg?att?cgt?ttc?taacggattg?tgttgaaact?gct 1158

Ala?Ile?Arg?Phe

345

<210>210

<211>345

<212>PRT

＜213〉Corynebacterium glutamicum

<400>210

Met?Thr?Thr?Ala?Ala?Pro?Gln?Glu?Phe?Thr?Ala?Ala?Val?Val?Glu?Lys

1 5 10 15

Phe?Gly?His?Asp?Val?Thr?Val?Lys?Asp?Ile?Asp?Leu?Pro?Lys?Pro?Gly

20 25 30

Pro?His?Gln?Ala?Leu?Val?Lys?Val?Leu?Thr?Ser?Gly?Ile?Cys?His?Thr

35 40 45

Asp?Leu?His?Ala?Leu?Glu?Gly?Asp?Trp?Pro?Val?Lys?Pro?Glu?Pro?Pro

50 55 60

Phe?Val?Pro?Gly?His?Glu?Gly?Val?Gly?Glu?Val?Val?Glu?Leu?Gly?Pro

65 70 75 80

Gly?Glu?His?Asp?Val?Lys?Val?Gly?Asp?Ile?Val?Gly?Asn?Ala?Trp?Leu

85 90 95

Trp?Ser?Ala?Cys?Gly?Thr?Cys?Glu?Tyr?Cys?Ile?Thr?Gly?Arg?Glu?Thr

100 105 110

Gln?Cys?Asn?Glu?Ala?Glu?Tyr?Gly?Gly?Tyr?Thr?Gln?Asn?Gly?Ser?Phe

115 120 125

Gly?Gln?Tyr?Met?Leu?Val?Asp?Thr?Arg?Tyr?Ala?Ala?Arg?Ile?Pro?Asp

130 135 140

Gly?Val?Asp?Tyr?Leu?Glu?Ala?Ala?Pro?Ile?Leu?Cys?Ala?Gly?Val?Thr

145 150 155 160

Val?Tyr?Lys?Ala?Leu?Lys?Val?Ser?Glu?Thr?Arg?Pro?Gly?Gln?Phe?Met

165 170 175

Val?Ile?Ser?Gly?Val?Gly?Gly?Leu?Gly?His?Ile?Ala?Val?Gln?Tyr?Ala

180 185 190

Ala?Ala?Met?Gly?Met?Arg?Val?Ile?Ala?Val?Asp?Ile?Ala?Asp?Asp?Lys

195 200 205

Leu?Glu?Leu?Ala?Arg?Lys?His?Gly?Ala?Glu?Phe?Thr?Val?Asn?Ala?Arg

210 215 220

Asn?Glu?Asp?Ser?Gly?Glu?Ala?Val?Gln?Lys?Tyr?Thr?Asn?Gly?Gly?Ala

225 230 235 240

His?Gly?Val?Leu?Val?Thr?Ala?Val?His?Glu?Ala?Ala?Phe?Gly?Gln?Ala

245 250 255

Leu?Asp?Met?Ala?Arg?Arg?Ala?Gly?Thr?Ile?Val?Phe?Asn?Gly?Leu?Pro

260 265 270

Pro?Gly?Glu?Phe?Pro?Ala?Ser?Val?Phe?Asn?Ile?Val?Phe?Lys?Gly?Leu

275 280 285

Thr?Ile?Arg?Gly?Ser?Leu?Val?Gly?Thr?Arg?Gln?Asp?Leu?Ala?Glu?Ala

290 295 300

Leu?Asp?Phe?Phe?Ala?Arg?Gly?Leu?Ile?Lys?Pro?Thr?Val?Ser?Glu?Cys

305 310 315 320

Ser?Leu?Asp?Glu?Val?Asn?Gly?Val?Leu?Asp?Arg?Met?Arg?Asn?Gly?Lys

325 330 335

Ile?Asp?Gly?Arg?Val?Ala?Ile?Arg?Phe

340 345

<210>211

<211>723

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(700)

<223>RXA01571

<400>211

aaactacctg?ctgagagctt?tgtaatttac?ggtgtggttg?tggaggggtg?cgtcgagaag?60

cgctcgtagg?cgcttttgat?ttttcggtag?gctaactggg?gtg?agt?atc?tca?gta 115

Val?Ser?Ile?Ser?Val

1 5

aaa?gca?cta?caa?aag?tcc?ggc?cca?gaa?gca?cct?ttc?gag?gtc?aag?atc 163

Lys?Ala?Leu?Gln?Lys?Ser?Gly?Pro?Glu?Ala?Pro?Phe?Glu?Val?Lys?Ile

10 15 20

att?gaa?cgc?cgt?gac?cca?cgc?gca?gat?gat?gtg?gtt?att?gat?atc?aaa 211

Ile?Glu?Arg?Arg?Asp?Pro?Arg?Ala?Asp?Asp?Val?Val?Ile?Asp?Ile?Lys

25 30 35

gct?gcg?ggc?atc?tgc?cac?agc?gat?atc?cac?acc?atc?cgc?aac?gaa?tgg 259

Ala?Ala?Gly?Ile?Cys?His?Ser?Asp?Ile?His?Thr?Ile?Arg?Asn?Glu?Trp

40 45 50

ggc?gag?gcg?cac?ttc?ccg?ctc?acc?gtc?ggc?cac?gaa?atc?gca?ggc?gtt 307

Gly?Glu?Ala?His?Phe?Pro?Leu?Thr?Val?Gly?His?Glu?Ile?Ala?Gly?Val

55 60 65

gtc?tct?gcg?gtt?gga?tcc?gat?gta?acc?aaa?tgg?aaa?gtc?ggc?gac?cgc 355

Val?Ser?Ala?Val?Gly?Ser?Asp?Val?Thr?Lys?Trp?Lys?Val?Gly?Asp?Arg

70 75 80 85

gtg?ggc?gtc?ggc?tgc?ctc?gtt?aac?tcc?tgc?ggc?gaa?tgc?gaa?cag?tgc 403

Val?Gly?Val?Gly?Cys?Leu?Val?Asn?Ser?Cys?Gly?Glu?Cys?Glu?Gln?Cys

90 95 100

gtc?gca?gga?ttt?gaa?aac?aac?tgc?ctt?cgc?gga?aac?gtc?gga?acc?tac 451

Val?Ala?Gly?Phe?Glu?Asn?Asn?Cys?Leu?Arg?Gly?Asn?Val?Gly?Thr?Tyr

105 110 115

aac?tct?aac?gac?gtc?gac?ggc?acc?atc?acc?caa?ggc?ggc?tac?gct?gaa 499

Asn?Ser?Asn?Asp?Val?Asp?Gly?Thr?Ile?Thr?Gln?Gly?Gly?Tyr?Ala?Glu

120 125 130

aag?gta?gtg?gtc?aac?gaa?cgt?ttc?ctg?tgc?agc?atc?cca?gag?gaa?ctt 547

Lys?Val?Val?Val?Ash?Glu?Arg?Phe?Leu?Cys?Ser?Ile?Pro?Glu?Glu?Leu

135 140 145

aac?ttc?gat?gtc?gca?gca?cca?ctg?ctg?tgc?gca?ggc?atc?acc?acc?tac 595

Asn?Phe?Asp?Val?Ala?Ala?Pro?Leu?Leu?Cys?Ala?Gly?Ile?Thr?Thr?Tyr

150 155 160 165

tcc?cca?atc?gct?cgc?tgg?aac?gtt?aaa?gaa?ggc?gac?aaa?gta?gca?gtc 643

Ser?Pro?Ile?Ala?Arg?Trp?Asn?Val?Lys?Glu?Gly?Asp?Lys?Val?Ala?Val

170 175 180

atg?ggc?ctc?ggc?ggg?act?cgg?aca?cat?ggg?tgt?cca?gat?cgc?tgc?agc 691

Met?Gly?Leu?Gly?Gly?Thr?Arg?Thr?His?Gly?Cys?Pro?Asp?Arg?Cys?Ser

185 190 195

caa?ggg?tgc?tgaggttacc?gttctgtccc?gtt 723

Gln?Gly?Cys

200

<210>212

<211>200

<212>PRT

＜213〉Corynebacterium glutamicum

<400>212

Val?Ser?Ile?Ser?Val?Lys?Ala?Leu?Gln?Lys?Ser?Gly?Pro?Glu?Ala?Pro

1 5 10 15

Phe?Glu?Val?Lys?Ile?Ile?Glu?Arg?Arg?Asp?Pro?Arg?Ala?Asp?Asp?Val

20 25 30

Val?Ile?Asp?Ile?Lys?Ala?Ala?Gly?Ile?Cys?His?Ser?Asp?Ile?His?Thr

35 40 45

Ile?Arg?Asn?Glu?Trp?Gly?Glu?Ala?His?Phe?Pro?Leu?Thr?Val?Gly?His

50 55 60

Glu?Ile?Ala?Gly?Val?Val?Ser?Ala?Val?Gly?Ser?Asp?Val?Thr?Lys?Trp

65 70 75 80

Lys?Val?Gly?Asp?Arg?Val?Gly?Val?Gly?Cys?Leu?Val?Asn?Ser?Cys?Gly

85 90 95

Glu?Cys?Glu?Gln?Cys?Val?Ala?Gly?Phe?Glu?Asn?Asn?Cys?Leu?Arg?Gly

100 105 110

Asn?Val?Gly?Thr?Tyr?Asn?Ser?Asn?Asp?Val?Asp?Gly?Thr?Ile?Thr?Gln

115 120 125

Gly?Gly?Tyr?Ala?Glu?Lys?Val?Val?Val?Asn?Glu?Arg?Phe?Leu?Cys?Ser

130 135 140

Ile?Pro?Glu?Glu?Leu?Asn?Phe?Asp?Val?Ala?Ala?Pro?Leu?Leu?Cys?Ala

145 150 155 160

Gly?Ile?Thr?Thr?Tyr?Ser?Pro?Ile?Ala?Arg?Trp?Asn?Val?Lys?Glu?Gly

165 170 175

Asp?Lys?Val?Ala?Val?Met?Gly?Leu?Gly?Gly?Thr?Arg?Thr?His?Gly?Cys

180 185 190

Pro?Asp?Arg?Cys?Ser?Gln?Gly?Cys

195 200

<210>213

<211>615

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(592)

<223>RXA01572

<400>213

ctgctgtgcg?caggcatcac?cacctactcc?ccaatcgctc?gctggaacgt?taaagaaggc?60

gacaaagtag?cagtcatggg?cctcggcggg?actcggacac?atg?ggt?gtc?cag?atc 115

Met?Gly?Val?Gln?Ile

1 5

gct?gca?gcc?aag?ggt?gct?gag?gtt?acc?gtt?ctg?tcc?cgt?tcc?ctg?cgc 163

Ala?Ala?Ala?Lys?Gly?Ala?Glu?Val?Thr?Val?Leu?Ser?Arg?Ser?Leu?Arg

10 15 20

aag?gca?gaa?ctt?gcc?aag?gaa?ctc?ggc?gca?gct?cgc?acg?ctt?gcg?act 211

Lys?Ala?Glu?Leu?Ala?Lys?Glu?Leu?Gly?Ala?Ala?Arg?Thr?Leu?Ala?Thr

25 30 35

tct?gat?gag?gat?ttc?ttc?acc?gaa?cac?gcc?ggt?gaa?ttc?gac?ttc?atc 259

Ser?Asp?Glu?Asp?Phe?Phe?Thr?Glu?His?Ala?Gly?Glu?Phe?Asp?Phe?Ile

40 45 50

ctc?aac?acc?att?agc?gca?tcc?atc?cca?gtc?gac?aag?tac?ctg?agc?ctt 307

Leu?Asn?Thr?Ile?Ser?Ala?Ser?Ile?Pro?Val?Asp?Lys?Tyr?Leu?Ser?Leu

55 60 65

ctc?aag?cca?cac?ggt?gtc?atg?gct?gtt?gtc?ggt?ctg?cca?cca?gag?aag 355

Leu?Lys?Pro?His?Gly?Val?Met?Ala?Val?Val?Gly?Leu?Pro?Pro?Glu?Lys

70 75 80 85

cag?cca?ctg?agc?ttc?ggt?gcg?ctc?atc?ggc?ggc?gga?aaa?gtc?ctc?acc 403

Gln?Pro?Leu?Ser?Phe?Gly?Ala?Leu?Ile?Gly?Gly?Gly?Lys?Val?Leu?Thr

90 95 100

gga?tcc?aac?att?ggc?ggc?atc?cct?gaa?acc?cag?gaa?atg?ctc?gac?ttc 451

Gly?Ser?Asn?Ile?Gly?Gly?Ile?Pro?Glu?Thr?Gln?Glu?Met?Leu?Asp?Phe

105 110 115

tgt?gca?aaa?cac?ggc?ctc?ggt?gcg?atg?atc?gaa?act?gtc?ggc?gtc?aac 499

Cys?Ala?Lys?His?Gly?Leu?Gly?Ala?Met?Ile?Glu?Thr?Val?Gly?Val?Asn

120 125 130

gat?gtt?gat?gca?gcc?tac?gac?cgt?gtt?gtt?gcc?ggc?gac?gtt?cag?ttc 547

Asp?Val?Asp?Ala?Ala?Tyr?Asp?Arg?Val?Val?Ala?Gly?Asp?Val?Gln?Phe

135 140 145

cgc?gtt?gtc?att?gat?act?gct?tcg?ttt?gct?gag?gtt?gag?gcg?gtt 592

Arg?Val?Val?Ile?Asp?Thr?Ala?Ser?Phe?Ala?Glu?Val?Glu?Ala?Val

150 155 160

taggtttact?gaagttcaga?ctt 615

<210>214

<211>164

<212>PRT

＜213〉Corynebacterium glutamicum

<400>214

Met?Gly?Val?Gln?Ile?Ala?Ala?Ala?Lys?Gly?Ala?Glu?Val?Thr?Val?Leu

1 5 10 15

Ser?Arg?Ser?Leu?Arg?Lys?Ala?Glu?Leu?Ala?Lys?Glu?Leu?Gly?Ala?Ala

20 25 30

Arg?Thr?Leu?Ala?Thr?Ser?Asp?Glu?Asp?Phe?Phe?Thr?Glu?His?Ala?Gly

35 40 45

Glu?Phe?Asp?Phe?Ile?Leu?Asn?Thr?Ile?Ser?Ala?Ser?Ile?Pro?Val?Asp

50 55 60

Lys?Tyr?Leu?Ser?Leu?Leu?Lys?Pro?His?Gly?Val?Met?Ala?Val?Val?Gly

65 70 75 80

Leu?Pro?Pro?Glu?Lys?Gln?Pro?Leu?Ser?Phe?Gly?Ala?Leu?Ile?Gly?Gly

85 90 95

Gly?Lys?Val?Leu?Thr?Gly?Ser?Asn?Ile?Gly?Gly?Ile?Pro?Glu?Thr?Gln

100 105 110

Glu?Met?Leu?Asp?Phe?Cys?Ala?Lys?His?Gly?Leu?Gly?Ala?Met?Ile?Glu

115 120 125

Thr?Val?Gly?Val?Asn?Asp?Val?Asp?Ala?Ala?Tyr?Asp?Arg?Val?Val?Ala

130 135 140

Gly?Asp?Val?Gln?Phe?Arg?Val?Val?Ile?Asp?Thr?Ala?Ser?Phe?Ala?Glu

145 150 155 160

Val?Glu?Ala?Val

<210>215

<211>1140

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1117)

<223>RXA01758

<400>215

cccccttatt?cagagtgatg?gtctaccgga?gaagtaccca?gaccaatagc?atcgaccaac?60

gatagcgcgc?tcagaagttc?tttagtgaaa?gcagaaccaa?atg?ccc?aaa?tac?att 115

Met?Pro?Lys?Tyr?Ile

1 5

gcc?atg?cag?gta?tcc?gaa?tcc?ggt?gca?ccg?tta?gcc?gcg?aat?ctc?gtg 163

Ala?Met?Gln?Val?Ser?Glu?Ser?Gly?Ala?Pro?Leu?Ala?Ala?Asn?Leu?Val

10 15 20

caa?cct?gct?ccg?ttg?aaa?tcg?agg?gaa?gtc?cgc?gtg?gaa?atc?gct?gct 211

Gln?Pro?Ala?Pro?Leu?Lys?Ser?Arg?Glu?Val?Arg?Val?Glu?Ile?Ala?Ala

25 30 35

agt?ggt?gtg?tgc?cat?gca?gat?att?ggc?acg?gca?gca?gca?tcg?ggg?aag 259

Ser?Gly?Val?Cys?His?Ala?Asp?Ile?Gly?Thr?Ala?Ala?Ala?Ser?Gly?Lys

40 45 50

cac?act?gtt?ttt?cct?gtt?acc?cct?ggt?cat?gag?att?gca?gga?acc?atc 307

His?Thr?Val?Phe?Pro?Val?Thr?Pro?Gly?His?Glu?Ile?Ala?Gly?Thr?Ile

55 60 65

gcg?gaa?att?ggt?gaa?aac?gta?tct?cgg?tgg?acg?gtt?ggt?gat?cgc?gtt 355

Ala?Glu?Ile?Gly?Glu?Asn?Val?Ser?Arg?Trp?Thr?Val?Gly?Asp?Arg?Val

70 75 80 85

gca?atc?ggt?tgg?ttt?ggt?ggc?aat?tgc?ggt?gac?tgc?gct?ttt?tgt?cgt 403

Ala?Ile?Gly?Trp?Phe?Gly?Gly?Asn?Cys?Gly?Asp?Cys?Ala?Phe?Cys?Arg

90 95 100

gca?ggt?gat?cct?gtg?cat?tgc?aga?gag?cgg?aag?att?cct?ggc?gtt?tct 451

Ala?Gly?Asp?Pro?Val?His?Cys?Arg?Glu?Arg?Lys?Ile?Pro?Gly?Val?Ser

105 110 ll5

tat?gcg?ggt?ggt?tgg?gca?cag?aat?att?gtt?gtt?cca?gcg?gag?gct?ctt 499

Tyr?Ala?Gly?Gly?Trp?Ala?Gln?Asn?Ile?Val?Val?Pro?Ala?Glu?Ala?Leu

120 125 130

gct?gcg?att?cca?gat?ggc?atg?gac?ttt?tac?gag?ccc?gcc?ccg?atg?ggc 547

Ala?Ala?Ile?Pro?Asp?Gly?Met?Asp?Phe?Tyr?Glu?Pro?Ala?Pro?Met?Gly

135 140 145

tgc?gca?ggt?gtg?aca?aca?ttc?aat?gcg?ttg?cga?aac?ctg?aag?ctg?gat 595

Cys?Ala?Gly?Val?Thr?Thr?Phe?Asn?Ala?Leu?Arg?Asn?Leu?Lys?Leu?Asp

150 155 160 165

ccc?ggt?gcg?gct?gtc?gcg?gtc?ttt?gga?atc?ggc?ggt?tta?gtg?cgc?cta 643

Pro?Gly?Ala?Ala?Val?Ala?Val?Phe?Gly?Ile?Gly?Gly?Leu?Val?Arg?Leu

170 175 180

gct?att?cag?ttt?gct?gcg?aaa?atg?ggt?tat?cga?acc?atc?acc?atc?gcc 691

Ala?Ile?Gln?Phe?Ala?Ala?Lys?Met?Gly?Tyr?Arg?Thr?Ile?Thr?Ile?Ala

185 190 195

cgc?ggt?tta?gag?cgt?gag?gag?cta?gct?agg?caa?ctt?ggc?gcc?aac?cac 739

Arg?Gly?Leu?Glu?Arg?Glu?Glu?Leu?Ala?Arg?Gln?Leu?Gly?Ala?Asn?His

200 205 210

tac?atc?gat?agc?aat?gat?ctg?cac?cct?ggc?cag?gcg?tta?ttt?gaa?ctt 787

Tyr?Ile?Asp?Ser?Asn?Asp?Leu?His?Pro?Gly?Gln?Ala?Leu?Phe?Glu?Leu

215 220 225

ggc?ggg?gct?gac?ttg?atc?ttg?tct?act?gcg?tcc?acc?acg?gag?cct?ctt 835

Gly?Gly?Ala?Asp?Leu?Ile?Leu?Ser?Thr?Ala?Ser?Thr?Thr?Glu?Pro?Leu

230 235 240 245

tcg?gag?ttg?tct?acc?ggt?ctt?tct?att?ggc?ggg?cag?cta?acc?att?atc 883

Ser?Glu?Leu?Ser?Thr?Gly?Leu?Ser?Ile?Gly?Gly?Gln?Leu?Thr?Ile?Ile

250 255 260

gga?gtt?gat?ggg?gga?gat?atc?acc?gtt?tcg?gca?gcc?caa?ttg?atg?atg 931

Gly?Val?Asp?Gly?Gly?Asp?Ile?Thr?Val?Ser?Ala?Ala?Gln?Leu?Met?Met

265 270 275

aac?cgt?cag?atc?atc?aca?ggt?cac?ctc?act?gga?agt?gcg?aat?gac?acg 979

Asn?Arg?Gln?Ile?Ile?Thr?Gly?His?Leu?Thr?Gly?Ser?Ala?Asn?Asp?Thr

280 285 290

gaa?cag?act?atg?aaa?ttt?gct?cat?ctc?cat?ggc?gtg?aaa?ccg?ctt?att 1027

Glu?Gln?Thr?Met?Lys?Phe?Ala?His?Leu?His?Gly?Val?Lys?Pro?Leu?Ile

295 300 305

gaa?cgg?atg?cct?ctc?gat?caa?gcc?aac?gag?gct?att?gca?cgt?att?tca 1075

Glu?Arg?Met?Pro?Leu?Asp?Gln?Ala?Asn?Glu?Ala?Ile?Ala?Arg?Ile?Ser

310 315 320 325

gct?ggt?aaa?cca?cgt?ttc?cgt?att?gtc?ttg?gag?ccg?aat?tca 1117

Ala?Gly?Lys?Pro?Arg?Phe?Arg?Ile?Val?Leu?Glu?Pro?Asn?Ser

330 335

taatgccaac?agcaagccca?att 1140

<210>216

<211>339

<212>PRT

＜213〉Corynebacterium glutamicum

<400>216

Met?Pro?Lys?Tyr?Ile?Ala?Met?Gln?Val?Ser?Glu?Ser?Gly?Ala?Pro?Leu

1 5 10 15

Ala?Ala?Asn?Leu?Val?Gln?Pro?Ala?Pro?Leu?Lys?Ser?Arg?Glu?Val?Arg

20 25 30

Val?Glu?Ile?Ala?Ala?Ser?Gly?Val?Cys?His?Ala?Asp?Ile?Gly?Thr?Ala

35 40 45

Ala?Ala?Ser?Gly?Lys?His?Thr?Val?Phe?Pro?Val?Thr?Pro?Gly?His?Glu

50 55 60

Ile?Ala?Gly?Thr?Ile?Ala?Glu?Ile?Gly?Glu?Asn?Val?Ser?Arg?Trp?Thr

65 70 75 80

Val?Gly?Asp?Arg?Val?Ala?Ile?Gly?Trp?Phe?Gly?Gly?Asn?Cys?Gly?Asp

85 90 95

Cys?Ala?Phe?Cys?Arg?Ala?Gly?Asp?Pro?Val?His?Cys?Arg?Glu?Arg?Lys

100 105 110

Ile?Pro?Gly?Val?Ser?Tyr?Ala?Gly?Gly?Trp?Ala?Gln?Asn?Ile?Val?Val

115 120 125

Pro?Ala?Glu?Ala?Leu?Ala?Ala?Ile?Pro?Asp?Gly?Met?Asp?Phe?Tyr?Glu

130 135 140

Pro?Ala?Pro?Met?Gly?Cys?Ala?Gly?Val?Thr?Thr?Phe?Asn?Ala?Leu?Arg

145 150 155 160

Asn?Leu?Lys?Leu?Asp?Pro?Gly?Ala?Ala?Val?Ala?Val?Phe?Gly?Ile?Gly

165 170 175

Gly?Leu?Val?Arg?Leu?Ala?Ile?Gln?Phe?Ala?Ala?Lys?Met?Gly?Tyr?Arg

180 185 190

Thr?Ile?Thr?Ile?Ala?Arg?Gly?Leu?Glu?Arg?Glu?Glu?Leu?Ala?Arg?Gln

195 200 205

Leu?Gly?Ala?Asn?His?Tyr?Ile?Asp?Ser?Asn?Asp?Leu?His?Pro?Gly?Gln

210 215 220

Ala?Leu?Phe?Glu?Leu?Gly?Gly?Ala?Asp?Leu?Ile?Leu?Ser?Thr?Ala?Ser

225 230 235 240

Thr?Thr?Glu?Pro?Leu?Ser?Glu?Leu?Ser?Thr?Gly?Leu?Ser?Ile?Gly?Gly

245 250 255

Gln?Leu?Thr?Ile?Ile?Gly?Val?Asp?Gly?Gly?Asp?Ile?Thr?Val?Ser?Ala

260 265 270

Ala?Gln?Leu?Met?Met?Asn?Arg?Gln?Ile?Ile?Thr?Gly?His?Leu?Thr?Gly

275 280 285

Ser?Ala?Asn?Asp?Thr?Glu?Gln?Thr?Met?Lys?Phe?Ala?His?Leu?His?Gly

290 295 300

Val?Lys?Pro?Leu?Ile?Glu?Arg?Met?Pro?Leu?Asp?Gln?Ala?Asn?Glu?Ala

305 310 315 320

Ile?Ala?Arg?Ile?Ser?Ala?Gly?Lys?Pro?Arg?Phe?Arg?Ile?Val?Leu?Glu

325 330 335

Pro?Asn?Ser

<210>217

<211>1641

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1618)

<223>RXA02539

<400>217

ggctgctaag?cgtgcgaatg?tgcgcgttgt?cacaatcgtt?gaccaagtgt?cacctgacgc?60

acaggtagtg?ctcaggtgga?ggtggcccaa?aggagaccca?atg?act?gtc?tac?gca 115

Met?Thr?Val?Tyr?Ala

1 5

aat?cca?gga?acc?gaa?ggc?tcg?atc?gtt?aac?tat?gaa?aag?cgc?tac?gag 163

Asn?Pro?Gly?Thr?Glu?Gly?Ser?Ile?Val?Asn?Tyr?Glu?Lys?Arg?Tyr?Glu

10 15 20

aac?tac?att?ggt?ggc?aag?tgg?gtt?cca?ccg?gta?gag?ggc?cag?tac?ctt 211

Asn?Tyr?Ile?Gly?Gly?Lys?Trp?Val?Pro?Pro?Val?Glu?Gly?Gln?Tyr?Leu

25 30 35

gag?aac?att?tca?cct?gtc?act?ggt?gaa?gtt?ttc?tgt?gag?gtc?gca?cgt 259

Glu?Asn?Ile?Ser?Pro?Val?Thr?Gly?Glu?Val?Phe?Cys?Glu?Val?Ala?Arg

40 45 50

ggc?acc?gca?gcg?gac?gtg?gag?ctt?gca?ctg?gat?gct?gca?cat?gca?gcc 307

Gly?Thr?Ala?Ala?Asp?Val?Glu?Leu?Ala?Leu?Asp?Ala?Ala?His?Ala?Ala

55 60 65

gct?gat?gcg?tgg?ggc?aag?act?tct?gtc?gct?gaa?cgt?gct?ctg?atc?ctg 355

Ala?Asp?Ala?Trp?Gly?Lys?Thr?Ser?Val?Ala?Glu?Arg?Ala?Leu?Ile?Leu

70 75 80 85

cac?cgc?att?gcg?gac?cgc?atg?gaa?gag?cac?ctg?gaa?gaa?atc?gca?gtt 403

His?Arg?Ile?Ala?Asp?Arg?Met?Glu?Glu?His?Leu?Glu?Glu?Ile?Ala?Val

90 95 100

gca?gaa?acc?tgg?gag?aac?ggc?aag?gca?gtc?cgt?gag?act?ctt?gct?gca 451

Ala?Glu?Thr?Trp?Glu?Asn?Gly?Lys?Ala?Val?Arg?Glu?Thr?Leu?Ala?Ala

105 110 115

gat?atc?cca?ctg?gca?atc?gac?cac?ttc?cgc?tac?ttt?gct?ggc?gcg?atc 499

Asp?Ile?Pro?Leu?Ala?Ile?Asp?His?Phe?Arg?Tyr?Phe?Ala?Gly?Ala?Ile

120 125 130

cgt?gct?cag?gaa?gat?cgt?tcc?tca?cag?atc?gac?cac?aac?act?gtt?gct 547

Arg?Ala?Gln?Glu?Asp?Arg?Ser?Ser?Gln?Ile?Asp?His?Asn?Thr?Val?Ala

135 140 145

tac?cac?ttc?aac?gag?cca?atc?ggt?gtt?gtt?ggt?cag?atc?att?cct?tgg 595

Tyr?His?Phe?Asn?Glu?Pro?Ile?Gly?Val?Val?Gly?Gln?Ile?Ile?Pro?Trp

150 155 160 165

aac?ttc?cca?atc?ctc?atg?gct?acc?tgg?aag?ctc?gca?ccg?gca?ctt?gct 643

Asn?Phe?Pro?Ile?Leu?Met?Ala?Thr?Trp?Lys?Leu?Ala?Pro?Ala?Leu?Ala

170 175 180

gca?ggt?aac?gcg?atc?gtc?atg?aag?cca?gct?gag?cag?acc?cca?gca?tcc 691

Ala?Gly?Asn?Ala?Ile?Val?Met?Lys?Pro?Ala?Glu?Gln?Thr?Pro?Ala?Ser

185 190 195

att?ttg?tat?ctg?att?aac?atc?atc?ggc?gat?ctc?atc?cca?gag?ggc?gtc 739

Ile?Leu?Tyr?Leu?Ile?Asn?Ile?Ile?Gly?Asp?Leu?Ile?Pro?Glu?Gly?Val

200 205 210

ctc?aac?atc?gtc?aac?gga?ctc?ggc?ggt?gaa?gca?ggc?gct?gca?ctg?tcc 787

Leu?Asn?Ile?Val?Asn?Gly?Leu?Gly?Gly?Glu?Ala?Gly?Ala?Ala?Leu?Ser

215 220 225

ggc?tct?aat?cgg?att?ggc?aag?att?gct?ttc?acc?ggt?tcc?acc?gag?gtc 835

Gly?Ser?Asn?Arg?Ile?Gly?Lys?Ile?Ala?Phe?Thr?Gly?Ser?Thr?Glu?Val

230 235 240 245

ggc?aag?ctg?atc?aac?cgc?gct?gca?tcc?gac?aag?atc?att?cct?gtc?acc 883

Gly?Lys?Leu?Ile?Asn?Arg?Ala?Ala?Ser?Asp?Lys?Ile?Ile?Pro?Val?Thr

250 255 260

ctg?gag?ctc?ggc?ggt?aag?tcc?cca?tcc?atc?ttc?ttc?tcc?gat?gtt?ctg 931

Leu?Glu?Leu?Gly?Gly?Lys?Ser?Pro?Ser?Ile?Phe?Phe?Ser?Asp?Val?Leu

265 270 275

tca?cag?gat?gac?gcc?ttc?gca?gag?aag?gca?gtt?gaa?ggc?ttc?gcg?atg 979

Ser?Gln?Asp?Asp?Ala?Phe?Ala?Glu?Lys?Ala?Val?Glu?Gly?Phe?Ala?Met

280 285 290

ttc?gcc?ctc?aat?cag?ggt?gaa?gtt?tgt?acc?tgt?cct?tcc?cgt?gca?ctt 1027

Phe?Ala?Leu?Asn?Gln?Gly?Glu?Val?Cys?Thr?Cys?Pro?Ser?Arg?Ala?Leu

295 300 305

gtt?cat?gag?tcc?atc?gct?gat?gaa?ttc?ctc?gag?ctt?ggc?gtg?aag?cga 1075

Val?His?Glu?Ser?Ile?Ala?Asp?Glu?Phe?Leu?Glu?Leu?Gly?Val?Lys?Arg

310 315 320 325

gtt?cag?aac?atc?aag?ctg?ggt?aac?cca?ctt?gat?act?gaa?acc?atg?atg 1123

Val?Gln?Asn?Ile?Lys?Leu?Gly?Asn?Pro?Leu?Asp?Thr?Glu?Thr?Met?Met

330 335 340

ggt?gct?cag?gcg?tcc?cag?gag?cag?atg?gac?aag?atc?tcc?tcc?tac?ctg 1171

Gly?Ala?Gln?Ala?Ser?Gln?Glu?Gln?Met?Asp?Lys?Ile?Ser?Ser?Tyr?Leu

345 350 355

aag?atc?ggc?cca?gaa?gaa?ggc?gct?caa?acc?ctc?act?ggt?ggc?aag?gtc 1219

Lys?Ile?Gly?Pro?Glu?Glu?Gly?Ala?Gln?Thr?Leu?Thr?Gly?Gly?Lys?Val

360 365 370

aac?aag?gtt?gat?ggc?atg?gag?aac?ggt?tac?tac?att?gag?cca?acc?gtt 1267

Asn?Lys?Val?Asp?Gly?Met?Glu?Asn?Gly?Tyr?Tyr?Ile?Glu?Pro?Thr?Val

375 380 385

ttc?cgc?ggc?acc?aac?gac?atg?agg?atc?ttc?cgc?gag?gaa?atc?ttc?gga 1315

Phe?Arg?Gly?Thr?Asn?Asp?Met?Arg?Ile?Phe?Arg?Glu?Glu?Ile?Phe?Gly

390 395 400 405

cca?gtc?ctt?tct?gtt?gct?acc?ttc?agc?gac?ttc?gat?gag?gcc?atc?cgt 1363

Pro?Val?Leu?Ser?Val?Ala?Thr?Phe?Ser?Asp?Phe?Asp?Glu?Ala?Ile?Arg

410 415 420

att?gca?aac?gac?acc?aac?tac?ggc?ctc?ggc?gct?ggt?gtc?tgg?agc?cgt 1411

Ile?Ala?Asn?Asp?Thr?Asn?Tyr?Gly?Leu?Gly?Ala?Gly?Val?Trp?Ser?Arg

425 430 435

gac?caa?aac?acc?att?tat?cgt?gca?ggt?cgc?gca?atc?cag?gct?ggt?cga 1459

Asp?Gln?Asn?Thr?Ile?Tyr?Arg?Ala?Gly?Arg?Ala?Ile?Gln?Ala?Gly?Arg

440 445 450

gtt?tgg?gtc?aac?cag?tac?cac?aac?tac?cca?gcg?cac?tcc?gct?ttc?ggt 1507

Val?Trp?Val?Asn?Gln?Tyr?His?Asn?Tyr?Pro?Ala?His?Ser?Ala?Phe?Gly

455 460 465

gga?tac?aag?gag?tcc?ggc?atc?ggc?cgt?gag?aac?cac?ctc?atg?atg?ctg 1555

Gly?Tyr?Lys?Glu?Ser?Gly?Ile?Gly?Arg?Glu?Asn?His?Leu?Met?Met?Leu

470 475 480 485

aac?cac?tac?cag?cag?acc?aag?aac?ctg?ttg?gtc?tcc?tac?gat?cca?aac 1603

Asn?His?Tyr?Gln?Gln?Thr?Lys?Asn?Leu?Leu?Val?Ser?Tyr?Asp?Pro?Asn

490 495 500

cca?acc?gga?ctg?ttc?tgatctaagc?gttaagtcct?aga 1641

Pro?Thr?Gly?Leu?Phe

505

<210>218

<211>506

<212>PRT

＜213〉Corynebacterium glutamicum

<400>218

Met?Thr?Val?Tyr?Ala?Asn?Pro?Gly?Thr?Glu?Gly?Ser?Ile?Val?Asn?Tyr

1 5 10 15

Glu?Lys?Arg?Tyr?Glu?Asn?Tyr?Ile?Gly?Gly?Lys?Trp?Val?Pro?Pro?Val

20 25 30

Glu?Gly?Gln?Tyr?Leu?Glu?Asn?Ile?Ser?Pro?Val?Thr?Gly?Glu?Val?Phe

35 40 45

Cys?Glu?Val?Ala?Arg?Gly?Thr?Ala?Ala?Asp?Val?Glu?Leu?Ala?Leu?Asp

50 55 60

Ala?Ala?His?Ala?Ala?Ala?Asp?Ala?Trp?Gly?Lys?Thr?Ser?Val?Ala?Glu

65 70 75 80

Arg?Ala?Leu?Ile?Leu?His?Arg?Ile?Ala?Asp?Arg?Met?Glu?Glu?His?Leu

85 90 95

Glu?Glu?Ile?Ala?Val?Ala?Glu?Thr?Trp?Glu?Asn?Gly?Lys?Ala?Val?Arg

100 105 110

Glu?Thr?Leu?Ala?Ala?Asp?Ile?Pro?Leu?Ala?Ile?Asp?His?Phe?Arg?Tyr

115 120 125

Phe?Ala?Gly?Ala?Ile?Arg?Ala?Gln?Glu?Asp?Arg?Ser?Ser?Gln?Ile?Asp

130 135 140

His?Asn?Thr?Val?Ala?Tyr?His?Phe?Asn?Glu?Pro?Ile?Gly?Val?Val?Gly

145 150 155 160

Gln?Ile?Ile?Pro?Trp?Asn?Phe?Pro?Ile?Leu?Met?Ala?Thr?Trp?Lys?Leu

165 170 175

Ala?Pro?Ala?Leu?Ala?Ala?Gly?Asn?Ala?Ile?Val?Met?Lys?Pro?Ala?Glu

180 185 190

Gln?Thr?Pro?Ala?Ser?Ile?Leu?Tyr?Leu?Ile?Asn?Ile?Ile?Gly?Asp?Leu

195 200 205

Ile?Pro?Glu?Gly?Val?Leu?Asn?Ile?Val?Asn?Gly?Leu?Gly?Gly?Glu?Ala

210 215 220

Gly?Ala?Ala?Leu?Ser?Gly?Ser?Asn?Arg?Ile?Gly?Lys?Ile?Ala?Phe?Thr

225 230 235 240

Gly?Ser?Thr?Glu?Val?Gly?Lys?Leu?Ile?Asn?Arg?Ala?Ala?Ser?Asp?Lys

245 250 255

Ile?Ile?Pro?Val?Thr?Leu?Glu?Leu?Gly?Gly?Lys?Ser?Pro?Ser?Ile?Phe

260 265 270

Phe?Ser?Asp?Val?Leu?Ser?Gln?Asp?Asp?Ala?Phe?Ala?Glu?Lys?Ala?Val

275 280 285

Glu?Gly?Phe?Ala?Met?Phe?Ala?Leu?Asn?Gln?Gly?Glu?Val?Cys?Thr?Cys

290 295 300

Pro?Ser?Arg?Ala?Leu?Val?His?Glu?Ser?Ile?Ala?Asp?Glu?Phe?Leu?Glu

305 310 315 320

Leu?Gly?Val?Lys?Arg?Val?Gln?Asn?Ile?Lys?Leu?Gly?Asn?Pro?Leu?Asp

325 330 335

Thr?Glu?Thr?Met?Met?Gly?Ala?Gln?Ala?Ser?Gln?Glu?Gln?Met?Asp?Lys

340 345 350

Ile?Ser?Ser?Tyr?Leu?Lys?Ile?Gly?Pro?Glu?Glu?Gly?Ala?Gln?Thr?Leu

355 360 365

Thr?Gly?Gly?Lys?Val?Asn?Lys?Val?Asp?Gly?Met?Glu?Asn?Gly?Tyr?Tyr

370 375 380

Ile?Glu?Pro?Thr?Val?Phe?Arg?Gly?Thr?Asn?Asp?Met?Arg?Ile?Phe?Arg

385 390 395 400

Glu?Glu?Ile?Phe?Gly?Pro?Val?Leu?Ser?Val?Ala?Thr?Phe?Ser?Asp?Phe

405 410 415

Asp?Glu?Ala?Ile?Arg?Ile?Ala?Asn?Asp?Thr?Asn?Tyr?Gly?Leu?Gly?Ala

420 425 430

Gly?Val?Trp?Ser?Arg?Asp?Gln?Asn?Thr?Ile?Tyr?Arg?Ala?Gly?Arg?Ala

435 440 445

Ile?Gln?Ala?Gly?Arg?Val?Trp?Val?Asn?Gln?Tyr?His?Asn?Tyr?Pro?Ala

450 455 460

His?Ser?Ala?Phe?Gly?Gly?Tyr?Lys?Glu?Ser?Gly?Ile?Gly?Arg?Glu?Asn

465 470 475 480

His?Leu?Met?Met?Leu?Asn?His?Tyr?Gln?Gln?Thr?Lys?Asn?Leu?Leu?Val

485 490 495

Ser?Tyr?Asp?Pro?Asn?Pro?Thr?Gly?Leu?Phe

500 505

<210>219

<211>430

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(430)

<223>RXN03061

<400>219

ctgccaccac?tggtcattgc?agaggacact?ctccgtgatg?gtcttcaggt?gttagtcgca?60

gccctagagc?gcgaaaccgc?gcaccagaag?gtgggctaaa?gtg?tct?ttg?acc?ttc 115

Val?Ser?Leu?Thr?Phe

1 5

cca?gta?atc?aac?ccc?agc?gat?ggc?tcc?acc?atc?acc?gag?cta?gaa?aac 163

Pro?Val?Ile?Asn?Pro?Ser?Asp?Gly?Ser?Thr?Ile?Thr?Glu?Leu?Glu?Asn

10 15 20

cac?gat?tcc?acc?cag?tgg?atg?tcc?gcg?ctc?tct?gat?gca?gtt?gca?gct 211

His?Asp?Ser?Thr?Gln?Trp?Met?Ser?Ala?Leu?Ser?Asp?Ala?Val?Ala?Ala

25 30 35

ggt?cct?tca?tgg?gct?gcg?aaa?act?ccc?cgc?gaa?aga?tcc?gtg?gta?ctc 259

Gly?Pro?Ser?Trp?Ala?Ala?Lys?Thr?Pro?Arg?Glu?Arg?Ser?Val?Val?Leu

40 45 50

acc?gca?atc?ttc?gaa?gca?ctg?acc?gaa?cgc?gcc?caa?gaa?ctt?gca?gag 307

Thr?Ala?Ile?Phe?Glu?Ala?Leu?Thr?Glu?Arg?Ala?Gln?Glu?Leu?Ala?Glu

55 60 65

atc?atc?cac?ctg?gaa?gct?gga?aaa?tcc?gat?gca?gaa?gct?ctt?ggt?gaa 355

Ile?Ile?His?Leu?Glu?Ala?Gly?Lys?Ser?Asp?Ala?Glu?Ala?Leu?Gly?Glu

70 75 80 85

gtc?gct?tat?ggt?gca?gaa?tac?ttc?cgt?tgg?ttt?gcg?gaa?gaa?gca?gtg 403

Val?Ala?Tyr?Gly?Ala?Glu?Tyr?Phe?Arg?Trp?Phe?Ala?Glu?Glu?Ala?Val

90 95 100

cgc?ctg?ccc?ggc?cgc?tac?gga?cag?tca 430

Arg?Leu?Pro?Gly?Arg?Tyr?Gly?Gln?Ser

105 110

<210>220

<211>110

<212>PRT

＜213〉Corynebacterium glutamicum

<400>220

Val?Ser?Leu?Thr?Phe?Pro?Val?Ile?Asn?Pro?Ser?Asp?Gly?Ser?Thr?Ile

1 5 10 15

Thr?Glu?Leu?Glu?Asn?His?Asp?Ser?Thr?Gln?Trp?Met?Ser?Ala?Leu?Ser

20 25 30

Asp?Ala?Val?Ala?Ala?Gly?Pro?Ser?Trp?Ala?Ala?Lys?Thr?Pro?Arg?Glu

35 40 45

Arg?Ser?Val?Val?Leu?Thr?Ala?Ile?Phe?Glu?Ala?Leu?Thr?Glu?Arg?Ala

50 55 60

Gln?Glu?Leu?Ala?Glu?Ile?Ile?His?Leu?Glu?Ala?Gly?Lys?Ser?Asp?Ala

65 70 75 80

Glu?Ala?Leu?Gly?Glu?Val?Ala?Tyr?Gly?Ala?Glu?Tyr?Phe?Arg?Trp?Phe

85 90 95

Ala?Glu?Glu?Ala?Val?Arg?Leu?Pro?Gly?Arg?Tyr?Gly?Gln?Ser

100 105 110

<210>221

<211>747

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(724)

<223>RXN03150

<400>221

tttaacagag?tgcgtttcaa?tgcctgtagt?gttccggcaa?ttttgaatgt?cgttacggtt?60

acccaaggct?gaattcctga?gctcaccttg?tacaagatca?gtg?gaa?gcc?cag?ttc 115

Val?Glu?Ala?Gln?Phe

1 5

acc?tct?ccc?ctg?ctc?aac?aat?ggg?caa?acc?tgt?ttc?ctt?ggt?acc?cga 163

Thr?Ser?Pro?Leu?Leu?Asn?Asn?Gly?Gln?Thr?Cys?Phe?Leu?Gly?Thr?Arg

10 15 20

atc?ctt?gct?cca?aaa?tca?cgt?tac?gcg?gaa?gta?gtc?gat?gca?ttc?acc 211

Ile?Leu?Ala?Pro?Lys?Ser?Arg?Tyr?Ala?Glu?Val?Val?Asp?Ala?Phe?Thr

25 30 35

gct?ttc?gct?ggc?agc?ctg?cag?gtt?gga?gtc?acg?tcc?tcc?cct?gac?act 259

Ala?Phe?Ala?Gly?Ser?Leu?Gln?Val?Gly?Val?Thr?Ser?Ser?Pro?Asp?Thr

40 45 50

cag?atc?gga?ccg?atg?gcg?act?gcc?cgg?cag?cgt?gag?cgc?gtg?gaa?tcc 307

Gln?Ile?Gly?Pro?Met?Ala?Thr?Ala?Arg?Gln?Arg?Glu?Arg?Val?Glu?Ser

55 60 65

tac?att?tcc?caa?ggc?aaa?aat?gct?gga?gcc?cgc?atc?act?gtc?ggt?ggc 355

Tyr?Ile?Ser?Gln?Gly?Lys?Asn?Ala?Gly?Ala?Arg?Ile?Thr?Val?Gly?Gly

70 75 80 85

agc?cgt?cca?cga?gat?ctt?gac?gcc?gga?ttc?ttc?gtt?gag?cca?aca?gtg 403

Ser?Arg?Pro?Arg?Asp?Leu?Asp?Ala?Gly?Phe?Phe?Val?Glu?Pro?Thr?Val

90 95 100

ttc?gcc?gat?gta?gac?aat?cgc?gca?gcc?att?gcc?caa?gat?gaa?atc?ttc 451

Phe?Ala?Asp?Val?Asp?Asn?Arg?Ala?Ala?Ile?Ala?Gln?Asp?Glu?Ile?Phe

105 110 115

gga?ccg?gtg?ccc?tct?gtt?gtt?tcc?tac?caa?gac?gat?gaa?cac?gcc?atc 499

Gly?Pro?Val?Pro?Ser?Val?Val?Ser?Tyr?Gln?Asp?Asp?Glu?His?Ala?Ile

120 125 130

caa?cta?gcc?aac?gat?tcc?gaa?ttc?ggt?ctc?ggc?gga?act?gtc?tgg?acg 547

Gln?Leu?Ala?Asn?Asp?Ser?Glu?Phe?Gly?Leu?Gly?Gly?Thr?Val?Trp?Thr

135 140 145

agc?gat?ccc?gag?cgc?ggc?gct?gca?ttg?gcc?cgc?cga?gtt?cac?aca?gga 595

Ser?Asp?Pro?Glu?Arg?Gly?Ala?Ala?Leu?Ala?Arg?Arg?Val?His?Thr?Gly

150 155 160 165

acc?att?ggc?atc?aac?cgc?tat?atc?cct?gat?ccc?gcc?gca?cca?ttt?gga 643

Thr?Ile?Gly?Ile?Asn?Arg?Tyr?Ile?Pro?Asp?Pro?Ala?Ala?Pro?Phe?Gly

170 175 180

ggt?gtg?aaa?aac?agt?ggc?ctt?ggc?aga?gaa?ctc?ggc?ccc?gaa?ggt?ctt 691

Gly?Val?Lys?Asn?Ser?Gly?Leu?Gly?Arg?Glu?Leu?Gly?Pro?Glu?Gly?Leu

185 190 195

gct?tcc?tac?caa?gaa?acc?caa?acc?att?tat?ctc?taatccaaac?tgcacctata?744

Ala?Ser?Tyr?Gln?Glu?Thr?Gln?Thr?Ile?Tyr?Leu

200 205

tat 747

<210>222

<211>208

<212>PRT

＜213〉Corynebacterium glutamicum

<400>222

Val?Glu?Ala?Gln?Phe?Thr?Ser?Pro?Leu?Leu?Asn?Asn?Gly?Gln?Thr?Cys

1 5 10 15

Phe?Leu?Gly?Thr?Arg?Ile?Leu?Ala?Pro?Lys?Ser?Arg?Tyr?Ala?Glu?Val

20 25 30

Val?Asp?Ala?Phe?Thr?Ala?Phe?Ala?Gly?Ser?Leu?Gln?Val?Gly?Val?Thr

35 40 45

Ser?Ser?Pro?Asp?Thr?Gln?Ile?Gly?Pro?Met?Ala?Thr?Ala?Arg?Gln?Arg

50 55 60

Glu?Arg?Val?Glu?Ser?Tyr?Ile?Ser?Gln?Gly?Lys?Asn?Ala?Gly?Ala?Arg

65 70 75 80

Ile?Thr?Val?Gly?Gly?Ser?Arg?Pro?Arg?Asp?Leu?Asp?Ala?Gly?Phe?Phe

85 90 95

Val?Glu?Pro?Thr?Val?Phe?Ala?Asp?Val?Asp?Asn?Arg?Ala?Ala?Ile?Ala

100 105 110

Gln?Asp?Glu?Ile?Phe?Gly?Pro?Val?Pro?Ser?Val?Val?Ser?Tyr?Gln?Asp

115 120 125

Asp?Glu?His?Ala?Ile?Gln?Leu?Ala?Asn?Asp?Ser?Glu?Phe?Gly?Leu?Gly

130 135 140

Gly?Thr?Val?Trp?Thr?Ser?Asp?Pro?Glu?Arg?Gly?Ala?Ala?Leu?Ala?Arg

145 150 155 160

Arg?Val?His?Thr?Gly?Thr?Ile?Gly?Ile?Asn?Arg?Tyr?Ile?Pro?Asp?Pro

165 170 175

Ala?Ala?Pro?Phe?Gly?Gly?Val?Lys?Asn?Ser?Gly?Leu?Gly?Arg?Glu?Leu

180 185 190

Gly?Pro?Glu?Gly?Leu?Ala?Ser?Tyr?Gln?Glu?Thr?Gln?Thr?Ile?Tyr?Leu

195 200 205

<210>223

<211>881

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(858)

<223>RXN01340

<400>223

aaa?gtg?ggg?gag?atc?atc?gcc?tcc?gtc?ttt?gat?acc?ttt?aat?atc?ccg 48

Lys?Val?Gly?Glu?Ile?Ile?Ala?Ser?Val?Phe?Asp?Thr?Phe?Asn?Ile?Pro

1 5 10 15

cag?ggc?ttg?gtc?tca?atc?atc?acc?acc?act?cga?gat?gca?gag?cta?tcg 96

Gln?Gly?Leu?Val?Ser?Ile?Ile?Thr?Thr?Thr?Arg?Asp?Ala?Glu?Leu?Ser

20 25 30

gca?gaa?ctc?atg?gct?gat?cct?cgc?ttg?gct?aaa?gtc?acc?ttc?act?gga 144

Ala?Glu?Leu?Met?Ala?Asp?Pro?Arg?Leu?Ala?Lys?Val?Thr?Phe?Thr?Gly

35 40 45

tca?acc?aac?gtg?gga?cgc?atc?ctg?gtc?cgc?caa?tcc?gcg?gac?cga?ctg 192

Ser?Thr?Asn?Val?Gly?Arg?Ile?Leu?Val?Arg?Gln?Ser?Ala?Asp?Arg?Leu

50 55 60

ctg?cgc?acc?tcc?atg?gaa?ctc?ggc?gga?aat?gca?gct?ttt?gtt?atc?gac 240

Leu?Arg?Thr?Ser?Met?Glu?Leu?Gly?Gly?Asn?Ala?Ala?Phe?Val?Ile?Asp

65 70 75 80

gaa?gcc?gca?gac?ctc?gac?gaa?gcc?gta?tcc?ggt?gcc?atc?gcc?gca?aaa 288

Glu?Ala?Ala?Asp?Leu?Asp?Glu?Ala?Val?Ser?Gly?Ala?Ile?Ala?Ala?Lys

85 90 95

ctc?cgc?aac?gcc?ggc?caa?gta?tgc?atc?gca?gct?aac?cgt?ttc?ttg?gtt 336

Leu?Arg?Asn?Ala?Gly?Gln?Val?Cys?Ile?Ala?Ala?Asn?Arg?Phe?Leu?Val

100 105 110

cat?gaa?tcc?cgc?gct?gcc?gaa?ttc?acc?tca?aag?ctg?gcg?aca?gcc?atg 384

His?Glu?Ser?Arg?Ala?Ala?Glu?Phe?Thr?Ser?Lys?Leu?Ala?Thr?Ala?Met

115 120 125

cag?aac?act?ccc?att?ggg?ccg?gtg?att?tct?gcc?cgc?caa?cgc?gac?cgg 432

Gln?Asn?Thr?Pro?Ile?Gly?Pro?Val?Ile?Ser?Ala?Arg?Gln?Arg?Asp?Arg

130 135 140

atc?gca?gca?cta?gtg?gat?gaa?gcc?atc?acc?gac?ggc?gcc?cgc?ctc?atc 480

Ile?Ala?Ala?Leu?Val?Asp?Glu?Ala?Ile?Thr?Asp?Gly?Ala?Arg?Leu?Ile

145 150 155 160

atc?ggt?ggg?gag?gtc?ccc?gac?ggc?tcc?ggc?ttc?ttc?tat?cca?gcc?acc 528

Ile?Gly?Gly?Glu?Val?Pro?Asp?Gly?Ser?Gly?Phe?Phe?Tyr?Pro?Ala?Thr

165 170 175

atc?ttg?gcc?gat?gtc?cct?gca?cag?tca?cgg?att?gtg?cat?gag?gaa?atc 576

Ile?Leu?Ala?Asp?Val?Pro?Ala?Gln?Ser?Arg?Ile?Val?His?Glu?Glu?Ile

180 185 190

ttc?gga?cct?gtg?gcc?acc?att?gcc?act?ttc?acc?gac?ttg?gcc?gaa?ggc 624

Phe?Gly?Pro?Val?Ala?Thr?Ile?Ala?Thr?Phe?Thr?Asp?Leu?Ala?Glu?Gly

195 200 205

gtt?gca?caa?gca?aat?tcc?acc?gaa?ttc?ggc?ctc?gca?gcc?tac?gga?ttc 672

Val?Ala?Gln?Ala?Asn?Ser?Thr?Glu?Phe?Gly?Leu?Ala?Ala?Tyr?Gly?Phe

210 215 220

agc?aac?aat?gtg?aaa?gca?aca?cag?tac?atg?gcg?gaa?cac?ttg?gaa?gcc 720

Ser?Asn?Asn?Val?Lys?Ala?Thr?Gln?Tyr?Met?Ala?Glu?His?Leu?Glu?Ala

225 230 235 240

gga?atg?gtc?gga?atc?aac?aga?ggc?gcc?atc?tct?gac?cca?gca?gca?cct 768

Gly?Met?Val?Gly?Ile?Asn?Arg?Gly?Ala?Ile?Ser?Asp?Pro?Ala?Ala?Pro

245 250 255

ttt?ggc?ggc?atc?gga?caa?tcc?ggc?ttc?ggc?aga?gaa?ggc?gga?acc?gaa 816

Phe?Gly?Gly?Ile?Gly?Gln?Ser?Gly?Phe?Gly?Arg?Glu?Gly?Gly?Thr?Glu

260 265 270

gga?atc?gaa?gaa?tat?ctc?tcc?gtg?cgt?tac?ctc?gct?ttg?ccg 858

Gly?Ile?Glu?Glu?Tyr?Leu?Ser?Val?Arg?Tyr?Leu?Ala?Leu?Pro

275 280 285

tgacacatga?gctgtccggt?gaa 881

<210>224

<211>286

<212>PRT

＜213〉Corynebacterium glutamicum

<400>224

Lys?Val?Gly?Glu?Ile?Ile?Ala?Ser?Val?Phe?Asp?Thr?Phe?Asn?Ile?Pro

1 5 10 15

Gln?Gly?Leu?Val?Ser?Ile?Ile?Thr?Thr?Thr?Arg?Asp?Ala?Glu?Leu?Ser

20 25 30

Ala?Glu?Leu?Met?Ala?Asp?Pro?Arg?Leu?Ala?Lys?Val?Thr?Phe?Thr?Gly

35 40 45

Ser?Thr?Asn?Val?Gly?Arg?Ile?Leu?Val?Arg?Gln?Ser?Ala?Asp?Arg?Leu

50 55 60

Leu?Arg?Thr?Ser?Met?Glu?Leu?Gly?Gly?Asn?Ala?Ala?Phe?Val?Ile?Asp

65 70 75 80

Glu?Ala?Ala?Asp?Leu?Asp?Glu?Ala?Val?Ser?Gly?Ala?Ile?Ala?Ala?Lys

85 90 95

Leu?Arg?Asn?Ala?Gly?Gln?Val?Cys?Ile?Ala?Ala?Asn?Arg?Phe?Leu?Val

100 105 110

His?Glu?Ser?Arg?Ala?Ala?Glu?Phe?Thr?Ser?Lys?Leu?Ala?Thr?Ala?Met

115 120 125

Gln?Asn?Thr?Pro?Ile?Gly?Pro?Val?Ile?Ser?Ala?Arg?Gln?Arg?Asp?Arg

130 135 140

Ile?Ala?Ala?Leu?Val?Asp?Glu?Ala?Ile?Thr?Asp?Gly?Ala?Arg?Leu?Ile

145 150 155 160

Ile?Gly?Gly?Glu?Val?Pro?Asp?Gly?Ser?Gly?Phe?Phe?Tyr?Pro?Ala?Thr

165 170 175

Ile?Leu?Ala?Asp?Val?Pro?Ala?Gln?Ser?Arg?Ile?Val?His?Glu?Glu?Ile

180 185 190

Phe?Gly?Pro?Val?Ala?Thr?Ile?Ala?Thr?Phe?Thr?Asp?Leu?Ala?Glu?Gly

195 200 205

Val?Ala?Gln?Ala?Asn?Ser?Thr?Glu?Phe?Gly?Leu?Ala?Ala?Tyr?Gly?Phe

210 215 220

Ser?Asn?Asn?Val?Lys?Ala?Thr?Gln?Tyr?Met?Ala?Glu?His?Leu?Glu?Ala

225 230 235 240

Gly?Met?Val?Gly?Ile?Asn?Arg?Gly?Ala?Ile?Ser?Asp?Pro?Ala?Ala?Pro

245 250 255

Phe?Gly?Gly?Ile?Gly?Gln?Ser?Gly?Phe?Gly?Arg?Glu?Gly?Gly?Thr?Glu

260 265 270

Gly?Ile?Glu?Glu?Tyr?Leu?Ser?Val?Arg?Tyr?Leu?Ala?Leu?Pro

275 280 285

<210>225

<211>1686

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1663)

<223>RXN01498

<400>225

cagtggacaa?ctacttggcg?ggtcttaaat?cagctgtgaa?ggattctgca?taagctgggc?60

accacacgag?catcagaacg?cgaaacgaag?gtaaaagccc?atg?atc?aaa?cgt?ctt 115

Met?Ile?Lys?Arg?Leu

1 5

cct?tta?ggt?ccg?ctg?cct?aaa?gaa?ctt?cat?cag?act?ctg?ctt?gat?ctg 163

Pro?Leu?Gly?Pro?Leu?Pro?Lys?Glu?Leu?His?Gln?Thr?Leu?Leu?Asp?Leu

10 15 20

acc?gca?aat?gcc?caa?gat?gcg?gcg?aaa?gtg?gag?gtt?ata?gcg?cca?ttt 211

Thr?Ala?Asn?Ala?Gln?Asp?Ala?Ala?Lys?Val?Glu?Val?Ile?Ala?Pro?Phe

25 30 35

act?ggc?gag?acc?ctc?gga?ttt?ggt?ttt?gat?ggt?gat?gag?caa?gac?gtc 259

Thr?Gly?Glu?Thr?Leu?Gly?Phe?Gly?Phe?Asp?Gly?Asp?Glu?Gln?Asp?Val

40 45 50

gag?cat?gct?ttt?gca?ctt?tca?agg?gca?gcc?cag?aaa?aag?tgg?gtg?cac 307

Glu?His?Ala?Phe?Ala?Leu?Ser?Arg?Ala?Ala?Gln?Lys?Lys?Trp?Val?His

55 60 65

acc?acg?gca?gtg?gaa?cgg?aag?aag?atc?ttc?ctg?aag?gtt?cat?gat?ctg 355

Thr?Thr?Ala?Val?Glu?Arg?Lys?Lys?Ile?Phe?Leu?Lys?Val?His?Asp?Leu

70 75 80 85

gta?ttg?aaa?aac?cgt?gag?ctg?ctc?atg?gac?atc?gtg?cag?ttg?gaa?aca 403

Val?Leu?Lys?Asn?Arg?Glu?Leu?Leu?Met?Asp?Ile?Val?Gln?Leu?Glu?Thr

90 95 100

ggc?aaa?aat?cga?gca?tcg?gct?gcc?gat?gag?gtg?ttg?gac?gtt?gcg?atc 451

Gly?Lys?Asn?Arg?Ala?Ser?Ala?Ala?Asp?Glu?Val?Leu?Asp?Val?Ala?Ile

105 110 115

acc?acc?cgc?ttc?tac?gca?aac?aat?gca?gga?aag?ttt?tta?aat?gac?aag 499

Thr?Thr?Arg?Phe?Tyr?Ala?Asn?Asn?Ala?Gly?Lys?Phe?Leu?Asn?Asp?Lys

120 125 130

aaa?cgc?ccc?ggc?gcg?ctt?ccg?atc?atc?acg?aaa?aac?aca?caa?cag?tat 547

Lys?Arg?Pro?Gly?Ala?Leu?Pro?Ile?Ile?Thr?Lys?Asn?Thr?Gln?Gln?Tyr

135 140 145

gtg?ccc?aag?gga?gtg?gtc?ggg?cag?atc?acg?ccg?tgg?aat?tac?cct?tta 595

Val?Pro?Lys?Gly?Val?Val?Gly?Gln?Ile?Thr?Pro?Trp?Asn?Tyr?Pro?Leu

150 155 160 165

act?ttg?gga?gta?tct?gat?gct?gtt?ccg?gcg?ctg?ctg?gca?gga?aac?gca 643

Thr?Leu?Gly?Val?Ser?Asp?Ala?Val?Pro?Ala?Leu?Leu?Ala?Gly?Asn?Ala

170 175 180

gtg?gtg?gct?aaa?cct?gac?ctc?gcg?aca?cct?ttc?tcc?tgc?ttg?atc?atg 691

Val?Val?Ala?Lys?Pro?Asp?Leu?Ala?Thr?Pro?Phe?Ser?Cys?Leu?Ile?Met

185 190 195

gtg?cac?ctg?ctc?att?gaa?gcc?ggt?ctg?ccg?cgt?gat?ttg?atg?cag?gtt 739

Val?His?Leu?Leu?Ile?Glu?Ala?Gly?Leu?Pro?Arg?Asp?Leu?Met?Gln?Val

200 205 210

gtc?acc?ggc?cct?ggc?gat?att?gtt?ggc?ggt?gcg?att?gca?gct?cag?tgt 787

Val?Thr?Gly?Pro?Gly?Asp?Ile?Val?Gly?Gly?Ala?Ile?Ala?Ala?Gln?Cys

215 220 225

gat?ttc?ctc?atg?ttc?act?gga?tcc?acg?gcc?acg?ggc?cgg?atc?ttg?ggt 835

Asp?Phe?Leu?Met?Phe?Thr?Gly?Ser?Thr?Ala?Thr?Gly?Arg?Ile?Leu?Gly

230 235 240 245

cgg?aca?atg?ggt?gag?cgt?ttg?gtg?ggt?ttc?tct?gcg?gaa?tta?ggc?gga 883

Arg?Thr?Met?Gly?Glu?Arg?Leu?Val?Gly?Phe?Ser?Ala?Glu?Leu?Gly?Gly

250 255 260

aag?aac?cct?ctt?att?gtg?gcc?aag?gat?gca?gat?ctg?gac?aag?gtg?gaa 931

Lys?Asn?Pro?Leu?Ile?Val?Ala?Lys?Asp?Ala?Asp?Leu?Asp?Lys?Val?Glu

265 270 275

gct?gag?ctt?ccg?cag?gcg?tgt?ttt?tcc?aac?tcg?ggg?caa?ttg?tgt?gtc 979

Ala?Glu?Leu?Pro?Gln?Ala?Cys?Phe?Ser?Asn?Ser?Gly?Gln?Leu?Cys?Val

280 285 290

tcc?act?gaa?cgt?att?tat?gtc?gag?gaa?gac?gtg?tac?gag?gag?gtg?att 1027

Ser?Thr?Glu?Arg?Ile?Tyr?Val?Glu?Glu?Asp?Val?Tyr?Glu?Glu?Val?Ile

295 300 305

gca?cgg?ttt?agc?aag?gcg?gcg?aaa?gcc?atg?tcc?att?ggt?gcc?gga?ttt 1075

Ala?Arg?Phe?Ser?Lys?Ala?Ala?Lys?Ala?Met?Ser?Ile?Gly?Ala?Gly?Phe

310 315 320 325

gag?tgg?aaa?tat?gag?atg?ggt?tcg?ttg?atc?aat?cac?gcg?cag?ctg?gat 1123

Glu?Trp?Lys?Tyr?Glu?Met?Gly?Ser?Leu?Ile?Asn?His?Ala?Gln?Leu?Asp

330 335 340

cgg?gtg?agc?acc?ttt?gtt?gat?cag?gct?aaa?gct?gcg?ggc?gcc?acg?gtg 1171

Arg?Val?Ser?Thr?Phe?Val?Asp?Gln?Ala?Lys?Ala?Ala?Gly?Ala?Thr?Val

345 350 355

ctg?tgc?ggt?ggc?aag?tca?cgc?cct?gat?att?ggt?ccc?ttc?ttc?tat?gag 1219

Leu?Cys?Gly?Gly?Lys?Ser?Arg?Pro?Asp?Ile?Gly?Pro?Phe?Phe?Tyr?Glu

360 365 370

ccc?acg?gta?ttg?gcg?gat?gtc?cca?gag?ggc?acc?cca?ctg?ctc?acg?gag 1267

Pro?Thr?Val?Leu?Ala?Asp?Val?Pro?Glu?Gly?Thr?Pro?Leu?Leu?Thr?Glu

375 380 385

gaa?gtc?ttc?ggg?ccg?gtg?gtg?ttc?atc?gaa?aag?gta?gcc?aca?ctg?gaa 1315

Glu?Val?Phe?Gly?Pro?Val?Val?Phe?Ile?Glu?Lys?Val?Ala?Thr?Leu?Glu

390 395 400 405

gaa?gcc?gtc?gat?aag?gca?aat?ggc?acg?ccc?tac?ggc?ctg?aat?gcg?tcc 1363

Glu?Ala?Val?Asp?Lys?Ala?Asn?Gly?Thr?Pro?Tyr?Gly?Leu?Asn?Ala?Ser

410 415 420

gtc?ttt?ggg?tcg?tcg?gaa?acc?ggc?aat?ctt?gtt?gca?ggc?cag?ctg?gaa 1411

Val?Phe?Gly?Ser?Ser?Glu?Thr?Gly?Asn?Leu?Val?Ala?Gly?Gln?Leu?Glu

425 430 435

gct?ggc?ggt?atc?ggt?att?aat?gat?ggc?tac?gcc?gcg?acg?tgg?gcg?agc 1459

Ala?Gly?Gly?Ile?Gly?Ile?Asn?Asp?Gly?Tyr?Ala?Ala?Thr?Trp?Ala?Ser

440 445 450

gtg?tcc?acg?cct?ctg?ggt?ggc?atg?aag?cag?tcg?ggg?ctg?ggg?cac?cgc 1507

Val?Ser?Thr?Pro?Leu?Gly?Gly?Met?Lys?Gln?Ser?Gly?Leu?Gly?His?Arg

455 460 465

cat?ggt?gcg?gag?gga?att?aca?aaa?tat?gcg?gag?atc?cga?aac?atc?gcg 1555

His?Gly?Ala?Glu?Gly?Ile?Thr?Lys?Tyr?Ala?Glu?Ile?Arg?Asn?Ile?Ala

470 475 480 485

gag?cag?cgc?tgg?atg?tct?atg?cgt?ggg?ccg?gcc?aaa?atg?ccg?cga?aag 1603

Glu?Gln?Arg?Trp?Met?Ser?Met?Arg?Gly?Pro?Ala?Lys?Met?Pro?Arg?Lys

490 495 500

gtg?tac?tca?gac?acc?gtg?gcc?aca?gcg?cta?aag?ctg?ggc?aaa?atc?ttt 1651

Val?Tyr?Ser?Asp?Thr?ValAla?Thr?Ala?Leu?Lys?Leu?Gly?Lys?Ile?Phe

505 510 515

aaa?gtt?ttg?ccg?tagcaaaaag?ccggaccctt?gct 1686

Lys?Val?Leu?Pro

520

<210>226

<211>521

<212>PRT

＜213〉Corynebacterium glutamicum

<400>226

Met?Ile?Lys?Arg?Leu?Pro?Leu?Gly?Pro?Leu?Pro?Lys?Glu?Leu?His?Gln

1 5 10 15

Thr?Leu?Leu?Asp?Leu?Thr?Ala?Asn?Ala?Gln?Asp?Ala?Ala?Lys?Val?Glu

20 25 30

Val?Ile?Ala?Pro?Phe?Thr?Gly?Glu?Thr?Leu?Gly?Phe?Gly?Phe?Asp?Gly

35 40 45

Asp?Glu?Gln?Asp?Val?Glu?His?Ala?Phe?Ala?Leu?Ser?Arg?Ala?Ala?Gln

50 55 60

Lys?Lys?Trp?Val?His?Thr?Thr?Ala?Val?Glu?Arg?Lys?Lys?Ile?Phe?Leu

65 70 75 80

Lys?Val?His?Asp?Leu?Val?Leu?Lys?Asn?Arg?Glu?Leu?Leu?Met?Asp?Ile

85 90 95

Val?Gln?Leu?Glu?Thr?Gly?Lys?Asn?Arg?Ala?Ser?Ala?Ala?Asp?Glu?Val

100 105 110

Leu?Asp?Val?Ala?Ile?Thr?Thr?Arg?Phe?Tyr?Ala?Asn?Asn?Ala?Gly?Lys

115 120 125

Phe?Leu?Asn?Asp?Lys?Lys?Arg?Pro?Gly?Ala?Leu?Pro?Ile?Ile?Thr?Lys

130 135 140

Asn?Thr?Gln?Gln?Tyr?Val?Pro?Lys?Gly?Val?Val?Gly?Gln?Ile?Thr?Pro

145 150 155 160

Trp?Asn?Tyr?Pro?Leu?Thr?Leu?Gly?Val?Ser?Asp?Ala?Val?Pro?Ala?Leu

165 170 175

Leu?Ala?Gly?Asn?Ala?Val?Val?Ala?Lys?Pro?Asp?Leu?Ala?Thr?Pro?Phe

180 185 190

Ser?Cys?Leu?Ile?Met?Val?His?Leu?Leu?Ile?Glu?Ala?Gly?Leu?Pro?Arg

195 200 205

Asp?Leu?Met?Gln?Val?Val?Thr?Gly?Pro?Gly?Asp?Ile?Val?Gly?Gly?Ala

210 215 220

Ile?Ala?Ala?Gln?Cys?Asp?Phe?Leu?Met?Phe?Thr?Gly?Ser?Thr?Ala?Thr

225 230 235 240

Gly?Arg?Ile?Leu?Gly?Arg?Thr?Met?Gly?Glu?Arg?Leu?Val?Gly?Phe?Ser

245 250 255

Ala?Glu?Leu?Gly?Gly?Lys?Asn?Pro?Leu?Ile?Val?Ala?Lys?Asp?Ala?Asp

260 265 270

Leu?Asp?Lys?Val?Glu?Ala?Glu?Leu?Pro?Gln?Ala?Cys?Phe?Ser?Asn?Ser

275 280 285

Gly?Gln?Leu?Cys?Val?Ser?Thr?Glu?Arg?Ile?Tyr?Val?Glu?Glu?Asp?Val

290 295 300

Tyr?Glu?Glu?Val?Ile?Ala?Arg?Phe?Ser?Lys?Ala?Ala?Lys?Ala?Met?Ser

305 310 315 320

lle?Gly?Ala?Gly?Phe?Glu?Trp?Lys?Tyr?Glu?Met?Gly?Ser?Leu?Ile?Asn

325 330 335

His?Ala?Gln?Leu?Asp?Arg?Val?Ser?Thr?Phe?Val?Asp?Gln?Ala?Lys?Ala

340 345 350

Ala?Gly?Ala?Thr?Val?Leu?Cys?Gly?Gly?Lys?Ser?Arg?Pro?Asp?Ile?Gly

355 360 365

Pro?Phe?Phe?Tyr?Glu?Pro?Thr?Val?Leu?Ala?Asp?Val?Pro?Glu?Gly?Thr

370 375 380

Pro?Leu?Leu?Thr?Glu?Glu?Val?Phe?Gly?Pro?Val?Val?Phe?Ile?Glu?Lys

385 390 395 400

Val?Ala?Thr?Leu?Glu?Glu?Ala?Val?Asp?Lys?Ala?Asn?Gly?Thr?Pro?Tyr

405 410 415

Gly?Leu?Asn?Ala?Ser?Val?Phe?Gly?Ser?Ser?Glu?Thr?Gly?Asn?Leu?Val

420 425 430

Ala?Gly?Gln?Leu?Glu?Ala?Gly?Gly?Ile?Gly?Ile?Asn?Asp?Gly?Tyr?Ala

435 440 445

Ala?Thr?Trp?Ala?Ser?Val?Ser?Thr?Pro?Leu?Gly?Gly?Met?Lys?Gln?Ser

450 455 460

Gly?Leu?Gly?His?Arg?His?Gly?Ala?Glu?Gly?Ile?Thr?Lys?Tyr?Ala?Glu

465 470 475 480

Ile?Arg?Asn?Ile?Ala?Glu?Gln?Arg?Trp?Met?Ser?Met?Arg?Gly?Pro?Ala

485 490 495

Lys?Met?Pro?Arg?Lys?Val?Tyr?Ser?Asp?Thr?Val?Ala?Thr?Ala?Leu?Lys

500 505 510

Leu?Gly?Lys?Ile?Phe?Lys?Val?Leu?Pro

515 520

<210>227

<211>1575

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1552)

<223>RXN02674

<400>227

atcgacctct?agggcagcag?tgattgattt?cataaaaatc?acaagtttgt?aactaaaggt?60

acagttggtg?aagtatccac?aatcaacttt?aggagacctt?gtg?act?gca?aca?ttt 115

Val?Thr?Ala?Thr?Phe

1 5

gct?gga?atc?gac?gcc?acc?aaa?cac?ctc?atc?gga?ggt?cag?tgg?gtg?gag 163

Ala?Gly?Ile?Asp?Ala?Thr?Lys?His?Leu?Ile?Gly?Gly?Gln?Trp?Val?Glu

10 15 20

gga?aac?tcg?gat?cga?att?tcc?acc?aat?atc?aat?cct?tac?gac?gat?tcc 211

Gly?Asn?Ser?Asp?Arg?Ile?Ser?Thr?Asn?Ile?Asn?Pro?Tyr?Asp?Asp?Ser

25 30 35

gta?atc?gcc?gaa?agc?aaa?caa?gct?tcc?att?gct?gat?gtt?gat?gcc?gcg 259

Val?Ile?Ala?Glu?Ser?Lys?Gln?Ala?Ser?Ile?Ala?Asp?Val?Asp?Ala?Ala

40 45 50

tat?gaa?gcc?gcg?aag?aag?gcc?cag?gct?gag?tgg?gca?gct?acg?ccc?gct 307

Tyr?Glu?Ala?Ala?Lys?Lys?Ala?Gln?Ala?Glu?Trp?Ala?Ala?Thr?Pro?Ala

55 60 65

gcg?gaa?cga?tct?gcc?atc?atc?tac?cgt?gcg?gct?gaa?ctt?ctt?gaa?gag 355

Ala?Glu?Arg?Ser?Ala?Ile?Ile?Tyr?Arg?Ala?Ala?Glu?Leu?Leu?Glu?Glu

70 75 80 85

cac?cgg?gag?gaa?atc?gtg?gaa?tgg?ctg?atc?aag?gaa?tcc?ggc?tcg?acg 403

His?Arg?Glu?Glu?Ile?Val?Glu?Trp?Leu?Ile?Lys?Glu?Ser?Gly?Ser?Thr

90 95 100

cgt?tcc?aag?gct?aat?ttg?gaa?atc?act?ttg?gca?gga?aac?atc?act?aaa 451

Arg?Ser?Lys?Ala?Asn?Leu?Glu?Ile?Thr?Leu?Ala?Gly?Asn?Ile?Thr?Lys

105 110 115

gaa?tcg?gct?tca?ttc?cct?ggt?cgt?gtg?cat?ggt?cga?att?tct?cct?tcg 499

Glu?Ser?Ala?Ser?Phe?Pro?Gly?Arg?Val?His?Gly?Arg?Ile?Ser?Pro?Ser

120 125 130

aat?act?ccg?ggc?aaa?gaa?aac?cgt?gtg?tac?cgc?gta?gcc?aag?ggc?gtt 547

Asn?Thr?Pro?Gly?Lys?Glu?Asn?Arg?Val?Tyr?Arg?Val?Ala?Lys?Gly?Val

135 140 145

gtc?gga?gtg?att?agt?cca?tgg?aat?ttc?cca?ctg?aac?ctc?tcg?atc?cgc 595

Val?Gly?Val?Ile?Ser?Pro?Trp?Asn?Phe?Pro?Leu?Asn?Leu?Ser?Ile?Arg

150 155 160 165

tcg?gtt?gct?ccg?gca?cta?gcc?gtg?ggc?aac?gcc?gta?gtg?att?aag?cct 643

Ser?Val?Ala?Pro?Ala?Leu?Ala?Val?Gly?Asn?Ala?Val?Val?Ile?Lys?Pro

170 175 180

gcg?agt?gat?acc?cca?gtt?act?ggt?ggt?gta?att?cct?gca?cga?atc?ttt 691

Ala?Ser?Asp?Thr?Pro?Val?Thr?Gly?Gly?Val?Ile?Pro?Ala?Arg?Ile?Phe

185 190 195

gag?gag?gcc?gga?gtt?cct?gca?ggc?gtg?atc?agc?acg?gtt?gcg?ggc?gca 739

Glu?Glu?Ala?Gly?Val?Pro?Ala?Gly?Val?Ile?Ser?Thr?Val?Ala?Gly?Ala

200 205 210

gga?tct?gaa?atc?ggt?gat?cac?ttt?gtc?acc?cac?gcc?gtg?cca?aag?ctg 787

Gly?Ser?Glu?Ile?Gly?Asp?His?Phe?Val?Thr?His?Ala?Val?Pro?Lys?Leu

215 220 225

att?tct?ttc?acc?ggt?tca?acc?cca?gtc?ggt?cgt?cgt?gtc?ggt?gag?ctg 835

Ile?Ser?Phe?Thr?Gly?Ser?Thr?Pro?Val?Gly?Arg?Arg?Val?Gly?Glu?Leu

230 235 240 245

gca?att?aat?ggt?gga?cca?atg?aaa?act?gtt?gca?cta?gag?ctc?ggt?ggc 883

Ala?Ile?Asn?Gly?Gly?Pro?Met?Lys?Thr?Val?Ala?Leu?Glu?Leu?Gly?Gly

250 255 260

aac?gcg?ccg?ttc?gtt?gtg?ctt?gcc?gac?gcc?gac?atc?gac?gcc?gct?gcc 931

Asn?Ala?Pro?Phe?Val?Val?Leu?Ala?Asp?Ala?Asp?Ile?Asp?Ala?Ala?Ala

265 270 275

cag?gct?gcc?gca?gtt?ggc?gct?ttc?cta?cac?cag?gga?cag?att?tgt?atg 979

Gln?Ala?Ala?Ala?Val?Gly?Ala?Phe?Leu?His?Gln?Gly?Gln?Ile?Cys?Met

280 285 290

tca?atc?aac?cga?gtc?att?gtt?gat?gct?gca?gtt?cat?gat?gaa?ttc?cta 1027

Ser?Ile?Asn?Arg?Val?Ile?Val?Asp?Ala?Ala?Val?His?Asp?Glu?Phe?Leu

295 300 305

gag?aag?ttc?gtt?gaa?gca?gtg?aag?aac?att?cca?acc?ggc?gat?cca?agc 1075

Glu?Lys?Phe?Val?Glu?Ala?Val?Lys?Asn?Ile?Pro?Thr?Gly?Asp?Pro?Ser

310 315 320 325

gca?gaa?gga?acc?ctt?gtt?gga?cct?gtc?att?aat?gac?agt?cag?ctc?agt 1123

Ala?Glu?Gly?Thr?Leu?Val?Gly?Pro?Val?Ile?Asn?Asp?Ser?Gln?Leu?Ser

330 335 340

ggt?ttg?aag?gaa?aag?atc?gag?ttg?gcc?aaa?aag?gaa?ggc?gca?acc?gtc ll71

Gly?Leu?Lys?Glu?Lys?Ile?Glu?Leu?Ala?Lys?Lys?Glu?Gly?Ala?Thr?Val

345 350 355

cag?gtt?gaa?ggg?cca?att?gaa?ggc?cga?ctg?gtt?cat?ccg?cat?gtg?ttc 1219

Gln?Val?Glu?Gly?Pro?Ile?Glu?Gly?Arg?Leu?Val?His?Pro?His?Val?Phe

360 365 370

tct?gat?gtc?acc?tct?gac?atg?gaa?atc?gct?cgt?gag?gaa?atc?ttc?gga 1267

Ser?Asp?Val?Thr?Ser?Asp?Met?Glu?Ile?Ala?Arg?Glu?Glu?Ile?Phe?Gly

375 380 385

cct?ctc?atc?agc?gtg?ctg?aag?gcc?gat?gat?gag?gca?cac?gca?gca?gag 1315

Pro?Leu?Ile?Ser?Val?Leu?Lys?Ala?Asp?Asp?Glu?Ala?His?Ala?Ala?Glu

390 395 400 405

ctg?gcc?aat?gct?tcc?gac?ttt?ggt?ttg?agc?gcg?gca?gtg?tgg?tcg?aag 1363

Leu?Ala?Asn?Ala?Ser?Asp?Phe?Gly?Leu?Ser?Ala?Ala?Val?Trp?Ser?Lys

410 415 420

gat?att?gat?cgt?gca?gcc?cag?ttt?gct?ctg?cag?att?gat?tcc?ggc?atg 1411

Asp?Ile?Asp?Arg?Ala?Ala?Gln?Phe?Ala?Leu?Gln?Ile?Asp?Ser?Gly?Met

425 430 435

gtt?cac?atc?aat?gac?ctc?acc?gtc?aac?gat?gaa?cca?cac?gtg?atg?ttc 1459

Val?His?Ile?Asn?Asp?Leu?Thr?Val?Asn?Asp?Glu?Pro?His?Val?Met?Phe

440 445 450

ggt?ggt?tca?aag?aac?tct?ggc?ctc?ggc?cgc?ttc?aac?ggc?gat?tgg?gcg 1507

Gly?Gly?Ser?Lys?Asn?Ser?Gly?Leu?Gly?Arg?Phe?Asn?Gly?Asp?Trp?Ala

455 460 465

atc?gag?gag?ttc?acc?aca?gat?cga?tgg?atc?ggc?atc?aag?cgc?agc 1552

Ile?Glu?Glu?Phe?Thr?Thr?Asp?Arg?Trp?Ile?Gly?Ile?Lys?Arg?Ser

470 475 480

taattgtttt?tcgacgtaac?ccc 1575

<210>228

<211>484

<212>PRT

＜213〉Corynebacterium glutamicum

<400>228

Val?Thr?Ala?Thr?Phe?Ala?Gly?Ile?Asp?Ala?Thr?Lys?His?Leu?Ile?Gly

1 5 10 15

Gly?Gln?Trp?Val?Glu?Gly?Asn?Ser?Asp?Arg?Ile?Ser?Thr?Asn?Ile?Asn

20 25 30

Pro?Tyr?Asp?Asp?Ser?Val?Ile?Ala?Glu?Ser?Lys?Gln?Ala?Ser?Ile?Ala

35 40 45

Asp?Val?Asp?Ala?Ala?Tyr?Glu?Ala?Ala?Lys?Lys?Ala?Gln?Ala?Glu?Trp

50 55 60

Ala?Ala?Thr?Pro?Ala?Ala?Glu?Arg?Ser?Ala?lle?lle?Tyr?Arg?Ala?Ala

65 70 75 80

Glu?Leu?Leu?Glu?Glu?His?Arg?Glu?Glu?Ile?Val?Glu?Trp?Leu?Ile?Lys

85 90 95

Glu?Ser?Gly?Ser?Thr?Arg?Ser?Lys?Ala?Asn?Leu?Glu?Ile?Thr?Leu?Ala

100 105 110

Gly?Asn?Ile?Thr?Lys?Glu?Ser?Ala?Ser?Phe?Pro?Gly?Arg?Val?His?Gly

115 120 125

Arg?Ile?Ser?Pro?Ser?Asn?Thr?Pro?Gly?Lys?Glu?Asn?Arg?Val?Tyr?Arg

130 135 140

Val?Ala?Lys?Gly?Val?Val?Gly?Val?Ile?Ser?Pro?Trp?Asn?Phe?Pro?Leu

145 150 155 160

Asn?Leu?Ser?Ile?Arg?Ser?Val?Ala?Pro?Ala?Leu?Ala?Val?Gly?Asn?Ala

165 170 175

Val?Val?Ile?Lys?Pro?Ala?Ser?Asp?Thr?Pro?Val?Thr?Gly?Gly?Val?lle

180 185 190

Pro?Ala?Arg?Ile?Phe?Glu?Glu?Ala?Gly?Val?Pro?Ala?Gly?Val?Ile?Ser

195 200 205

Thr?Val?Ala?Gly?Ala?Gly?Ser?Glu?Ile?Gly?Asp?His?Phe?Val?Thr?His

210 215 220

Ala?Val?Pro?Lys?Leu?Ile?Ser?Phe?Thr?Gly?Ser?Thr?Pro?Val?Gly?Arg

225 230 235 240

Arg?Val?Gly?Glu?Leu?Ala?Ile?Asn?Gly?Gly?Pro?Met?Lys?Thr?Val?Ala

245 250 255

Leu?Glu?Leu?Gly?Gly?Asn?Ala?Pro?Phe?Val?Val?Leu?Ala?Asp?Ala?Asp

260 265 270

Ile?Asp?Ala?Ala?Ala?Gln?Ala?Ala?Ala?Val?Gly?Ala?Phe?Leu?His?Gln

275 280 285

Gly?Gln?Ile?Cys?Met?Ser?Ile?Asn?Arg?Val?Ile?Val?Asp?Ala?Ala?Val

290 295 300

His?Asp?Glu?Phe?Leu?Glu?Lys?Phe?Val?Glu?Ala?Val?Lys?Asn?Ile?Pro

305 310 315 320

Thr?Gly?Asp?Pro?Ser?Ala?Glu?Gly?Thr?Leu?Val?Gly?Pro?Val?Ile?Asn

325 330 335

Asp?Ser?Gln?Leu?Ser?Gly?Leu?Lys?Glu?Lys?Ile?Glu?Leu?Ala?Lys?Lys

340 345 350

Glu?Gly?Ala?Thr?Val?Gln?Val?Glu?Gly?Pro?Ile?Glu?Gly?Arg?Leu?Val

355 360 365

His?Pro?His?Val?Phe?Ser?Asp?Val?Thr?Ser?Asp?Met?Glu?Ile?Ala?Arg

370 375 380

Glu?Glu?Ile?Phe?Gly?Pro?Leu?Ile?Ser?Val?Leu?Lys?Ala?Asp?Asp?Glu

385 390 395 400

Ala?His?Ala?Ala?Glu?Leu?Ala?Asn?Ala?Ser?Asp?Phe?Gly?Leu?Ser?Ala

405 410 415

Ala?Val?Trp?Ser?Lys?Asp?Ile?Asp?Arg?Ala?Ala?Gln?Phe?Ala?Leu?Gln

420 425 430

Ile?Asp?Ser?Gly?Met?Val?His?Ile?Asn?Asp?Leu?Thr?Val?Asn?Asp?Glu

435 440 445

Pro?His?Val?Met?Phe?Gly?Gly?Ser?Lys?Asn?Ser?Gly?Leu?Gly?Arg?Phe

450 455 460

Asn?Gly?Asp?Trp?Ala?Ile?Glu?Glu?Phe?Thr?Thr?Asp?Arg?Trp?Ile?Gly

465 470 475 480

Ile?Lys?Arg?Ser

<210>229

<211>2034

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(2011)

<223>RXN00868

<400>229

cgatgaccca?gcgcacgcct?gggttcgaga?tacatggacc?gggcaagcat?ttgatgatcg?60

cttgccatat?gagaacgcaa?acaaggaggg?ataaaatttc?atg?gct?gaa?acg?aag 115

Met?Ala?Glu?Thr?Lys

1 5

aga?atg?aca?gtt?agc?cag?gca?ctg?gtt?gaa?ttc?ctt?ggt?cac?cag?tgg 163

Arg?Met?Thr?Val?Ser?Gln?Ala?Leu?Val?Glu?Phe?Leu?Gly?His?Gln?Trp

10 15 20

act?gtc?gac?ggc?gat?atc?cgc?gag?cgc?acc?att?cca?ggc?atg?ttc?gga 211

Thr?Val?Asp?Gly?Asp?Ile?Arg?Glu?Arg?Thr?Ile?Pro?Gly?Met?Phe?Gly

25 30 35

att?ttc?gga?cac?gga?aac?gtt?gct?ggc?att?ggc?cag?gca?ctc?aag?cag 259

Ile?Phe?Gly?His?Gly?Asn?Val?Ala?Gly?Ile?Gly?Gln?Ala?Leu?Lys?Gln

40 45 50

tac?aac?gtt?gaa?caa?cct?gag?ctc?atg?ccg?tac?tac?cag?gct?cgt?aat 307

Tyr?Asn?Val?Glu?Gln?Pro?Glu?Leu?Met?Pro?Tyr?Tyr?Gln?Ala?Arg?Asn

55 60 65

gag?cag?gcg?atg?gtg?cac?cag?tct?gtt?gga?tat?gca?cgc?atg?cac?cgc 355

Glu?Gln?Ala?Met?Val?His?Gln?Ser?Val?Gly?Tyr?Ala?Arg?Met?His?Arg

70 75 80 85

cgt?cgt?ggc?aca?tac?gca?tct?gcc?gca?tct?gtt?gga?ccc?ggc?gcg?acc 403

Arg?Arg?Gly?Thr?Tyr?Ala?Ser?Ala?Ala?Ser?Val?Gly?Pro?Gly?Ala?Thr

90 95 l00

aac?ctg?tta?acc?ggt?gcg?gct?ctt?gct?acc?acc?aac?cgt?ttg?cca?gcg 451

Asn?Leu?Leu?Thr?Gly?Ala?Ala?Leu?Ala?Thr?Thr?Asn?Arg?Leu?Pro?Ala

105 110 115

ttg?ctg?ctg?cct?agt?gat?act?ttt?gcc?acc?cgc?gtg?gcg?gat?cca?gtg 499

Leu?Leu?Leu?Pro?Ser?Asp?Thr?Phe?Ala?Thr?Arg?Val?Ala?Asp?Pro?Val

120 125 130

ttg?cag?cag?ttg?gag?cag?cca?tgg?gat?atc?ggg?ctg?acg?gtt?aat?gat 547

Leu?Gln?Gln?Leu?Glu?Gln?Pro?Trp?Asp?Ile?Gly?Leu?Thr?Val?Asn?Asp

135 140 145

gct?ttc?cgc?cct?gtg?tct?aag?ttc?ttt?gat?cgg?gtg?cag?cgc?ccg?gag 595

Ala?Phe?Arg?Pro?Val?Ser?Lys?Phe?Phe?Asp?Arg?Val?Gln?Arg?Pro?Glu

150 155 160 165

cag?ttg?ttc?tct?att?gcg?ttg?gct?gcg?atg?cgt?gtg?ttg?act?gat?ccc 643

Gln?Leu?Phe?Ser?Ile?Ala?Leu?Ala?Ala?Met?Arg?Val?Leu?Thr?Asp?Pro

170 175 180

gca?gaa?acc?ggt?gcg?gtc?acc?att?gcg?ctt?cca?gaa?gat?gtg?cag?gct 691

Ala?Glu?Thr?Gly?Ala?Val?Thr?Ile?Ala?Leu?Pro?Glu?Asp?Val?Gln?Ala

185 190 195

gaa?atg?ctc?gat?gtg?ccg?gtg?gag?ttc?ttg?cag?gat?cgt?gag?tgg?cac 739

Glu?Met?Leu?Asp?Val?Pro?Val?Glu?Phe?Leu?Gln?Asp?Arg?Glu?Trp?His

200 205 210

att?agg?cgc?cca?cgt?cca?gag?cgt?gct?gcg?ttg?gct?cgt?gcg?att?gaa 787

Ile?Arg?Arg?Pro?Arg?Pro?Glu?Arg?Ala?Ala?Leu?Ala?Arg?Ala?Ile?Glu

215 220 225

gtc?atc?aaa?aac?gct?aag?aat?ccg?atg?atc?att?gct?ggt?ggc?gga?gtg 835

Val?Ile?Lys?Asn?Ala?Lys?Asn?Pro?Met?Ile?Ile?Ala?Gly?Gly?Gly?Val

230 235 240 245

ttg?tac?tcc?gat?gcg?gaa?acg?cag?ctg?cag?gca?ctt?gtg?gag?cag?act 883

Leu?Tyr?Ser?Asp?Ala?Glu?Thr?Gln?Leu?Gln?Ala?Leu?Val?Glu?Gln?Thr

250 255 260

ggc?att?cca?gtg?ggt?acc?tcc?caa?gct?ggt?ggt?ggc?gtg?ttg?gcg?tgg 931

Gly?Ile?Pro?Val?Gly?Thr?Ser?Gln?Ala?Gly?Gly?Gly?Val?Leu?Ala?Trp

265 270 275

gat?cat?gca?caa?aac?tta?ggt?ggt?gtg?ggt?gcc?acc?gga?acg?ttg?gct 979

Asp?His?Ala?Gln?Asn?Leu?Gly?Gly?Val?Gly?Ala?Thr?Gly?Thr?Leu?Ala

280 285 290

gcc?aac?cgc?att?gcg?ggt?gat?gct?gat?gtg?atc?atc?ggt?atc?ggt?act 1027

Ala?Asn?Arg?Ile?Ala?Gly?Asp?Ala?Asp?Val?Ile?Ile?Gly?Ile?Gly?Thr

295 300 305

cgt?tac?agc?gat?ttc?acc?acc?gca?tct?cgc?act?gcg?ttc?caa?aac?cct 1075

Arg?Tyr?Ser?Asp?Phe?Thr?Thr?Ala?Ser?Arg?Thr?Ala?Phe?Gln?Asn?Pro

310 315 320 325

gat?gtc?acc?ttc?atc?aac?atc?aat?gtt?gct?tcc?ttc?gat?gct?tac?aag 1123

Asp?Val?Thr?Phe?Ile?Asn?Ile?Asn?Val?Ala?Ser?Phe?Asp?Ala?Tyr?Lys

330 335 340

cat?ggc?act?cag?ttg?cct?gtg?att?gca?gat?gca?cgc?gag?gca?att?gtg 1171

His?Gly?Thr?Gln?Leu?Pro?Val?Ile?Ala?Asp?Ala?Arg?Glu?Ala?Ile?Val

345 350 355

gag?ctt?gct?gaa?gcc?ctg?cag?gga?ttc?acc?gtg?gca?gag?gat?tac?gcg 1219

Glu?Leu?Ala?Glu?Ala?Leu?Gln?Gly?Phe?Thr?Val?Ala?Glu?Asp?Tyr?Ala

360 365 370

cag?cgc?atc?gcg?aag?gaa?aag?gct?gcg?tgg?gac?gca?gaa?gta?gat?aag 1267

Gln?Arg?Ile?Ala?Lys?Glu?Lys?Ala?Ala?Trp?Asp?Ala?Glu?Val?Asp?Lys

375 380 385

tct?ttt?gcc?ccc?tcc?ggt?ctt?gcg?ctg?cct?gga?cag?ccg?gag?atc?atc 1315

Ser?Phe?Ala?Pro?Ser?Gly?Leu?Ala?Leu?Pro?Gly?Gln?Pro?Glu?Ile?Ile

390 395 400 405

ggc?gcg?gtg?cag?gcg?tcg?aca?agc?gaa?aaa?gac?gtc?att?gtg?cag?gcc 1363

Gly?Ala?Val?Gln?Ala?Ser?Thr?Ser?Glu?Lys?Asp?Val?Ile?Val?Gln?Ala

410 415 420

gct?gga?tcc?ttg?cct?ggt?gac?ctg?cac?aag?ctg?tgg?cgt?gtg?cgc?gat 1411

Ala?Gly?Ser?Leu?Pro?Gly?Asp?Leu?His?Lys?Leu?Trp?Arg?Val?Arg?Asp

425 430 435

gcg?ctg?ggc?tac?cac?gtg?gaa?tat?gcg?ttc?tcg?tgc?atg?ggc?tat?gaa 1459

Ala?Leu?Gly?Tyr?His?Val?Glu?Tyr?Ala?Phe?Ser?Cys?Met?Gly?Tyr?Glu

440 445 450

atc?gcg?ggc?ggt?atc?ggc?gcg?aag?cgt?gga?ctt?gat?gcc?gca?ggc?gat 1507

Ile?Ala?Gly?Gly?Ile?Gly?Ala?Lys?Arg?Gly?Leu?Asp?Ala?Ala?Gly?Asp

455 460 465

gac?cgc?gac?gtg?gtg?atc?atg?gtt?ggt?gat?ggg?tcc?tac?ctc?atg?ctc 1555

Asp?Arg?Asp?Val?Val?Ile?Met?Val?Gly?Asp?Gly?Ser?Tyr?Leu?Met?Leu

470 475 480 485

aac?act?gag?ctg?gtc?acg?gcc?gtg?gca?gaa?ggt?atc?aag?gtg?att?gtg 1603

Asn?Thr?Glu?Leu?Val?Thr?Ala?Val?Ala?Glu?Gly?Ile?Lys?Val?Ile?Val

490 495 500

gtg?ctc?atc?caa?aac?cac?ggt?tat?gcc?tcc?atc?ggc?cac?ctg?tct?gaa 1651

Val?Leu?Ile?Gln?Asn?His?Gly?Tyr?Ala?Ser?Ile?Gly?His?Leu?Ser?Glu

505 510 515

act?gtc?ggt?tcg?cag?cgt?ttt?ggt?act?tgg?tac?cgc?gaa?tat?gac?gct 1699

Thr?Val?Gly?Ser?Gln?Arg?Phe?Gly?Thr?Trp?Tyr?Arg?Glu?Tyr?Asp?Ala

520 525 530

gag?gcg?aaa?aac?ttc?cag?ggc?gag?cag?att?ctg?cct?gtt?gac?ctg?gcg 1747

Glu?Ala?Lys?Asn?Phe?Gln?Gly?Glu?Gln?Ile?Leu?Pro?Val?Asp?Leu?Ala

535 540 545

atg?aat?gca?cgc?agc?tac?ggc?atg?gat?gtc?att?gaa?gtg?gaa?cca?agc 1795

Met?Asn?Ala?Arg?Ser?Tyr?Gly?Met?Asp?Val?Ile?Glu?Val?Glu?Pro?Ser

550 555 560 565

gcg?aat?gcg?atc?gag?gat?ctc?aaa?gca?gcg?atg?gca?acc?gcg?aag?gct 1843

Ala?Asn?Ala?Ile?Glu?Asp?Leu?Lys?Ala?Ala?Met?Ala?Thr?Ala?Lys?Ala

570 575 580

tcg?gag?aaa?tcc?acc?ttc?atc?cac?atc?aac?agc?gat?ccg?ttg?atc?tac 1891

Ser?Glu?Lys?Ser?Thr?Phe?Ile?His?Ile?Asn?Ser?Asp?Pro?Leu?Ile?Tyr

585 590 595

gca?cca?gac?ggt?gct?ggt?tgg?tgg?gac?gtg?ccg?gtg?tcg?gag?acg?tcc 1939

Ala?Pro?Asp?Gly?Ala?Gly?Trp?Trp?Asp?Val?Pro?Val?Ser?Glu?Thr?Ser

600 605 610

act?ctg?gat?agc?acc?aac?gcg?gct?cgt?gaa?gat?tac?ctg?aaa?aac?caa 1987

Thr?Leu?Asp?Ser?Thr?Asn?Ala?Ala?Arg?Glu?Asp?Tyr?Leu?Lys?Asn?Gln

615 620 625

gcc?ctc?cag?cgt?ccg?ctg?ctc?ggc?taaaccagtt?ggctaaacca?aaa 2034

Ala?Leu?Gln?Arg?Pro?Leu?Leu?Gly

630 635

<210>230

<211>637

<212>PRT

＜213〉Corynebacterium glutamicum

<400>230

Met?Ala?Glu?Thr?Lys?Arg?Met?Thr?Val?Ser?Gln?Ala?Leu?Val?Glu?Phe

1 5 10 15

Leu?Gly?His?Gln?Trp?Thr?Val?Asp?Gly?Asp?Ile?Arg?Glu?Arg?Thr?Ile

20 25 30

Pro?Gly?Met?Phe?Gly?Ile?Phe?Gly?His?Gly?Asn?Val?Ala?Gly?Ile?Gly

35 40 45

Gln?Ala?Leu?Lys?Gln?Tyr?Asn?Val?Glu?Gln?Pro?Glu?Leu?Met?Pro?Tyr

50 55 60

Tyr?Gln?Ala?Arg?Asn?Glu?Gln?Ala?Met?Val?His?Gln?Ser?Val?Gly?Tyr

65 70 75 80

Ala?Arg?Met?His?Arg?Arg?Arg?Gly?Thr?Tyr?Ala?Ser?Ala?Ala?Ser?Val

85 90 95

Gly?Pro?Gly?Ala?Thr?Asn?Leu?Leu?Thr?Gly?Ala?Ala?Leu?Ala?Thr?Thr

100 105 110

Asn?Arg?Leu?Pro?Ala?Leu?Leu?Leu?Pro?Ser?Asp?Thr?Phe?Ala?Thr?Arg

115 120 125

Val?Ala?Asp?Pro?Val?Leu?Gln?Gln?Leu?Glu?Gln?Pro?Trp?Asp?Ile?Gly

130 135 140

Leu?Thr?Val?Asn?Asp?Ala?Phe?Arg?Pro?Val?Ser?Lys?Phe?Phe?Asp?Arg

145 150 155 160

Val?Gln?Arg?Pro?Glu?Gln?Leu?Phe?Ser?Ile?Ala?Leu?Ala?Ala?Met?Arg

165 170 175

Val?Leu?Thr?Asp?Pro?Ala?Glu?Thr?Gly?Ala?Val?Thr?Ile?Ala?Leu?Pro

180 185 190

Glu?Asp?Val?Gln?Ala?Glu?Met?Leu?Asp?Val?Pro?Val?Glu?Phe?Leu?Gln

195 200 205

Asp?Arg?Glu?Trp?His?Ile?Arg?Arg?Pro?Arg?Pro?Glu?Arg?Ala?Ala?Leu

210 215 220

Ala?Arg?Ala?Ile?Glu?Val?Ile?Lys?Asn?Ala?Lys?Asn?Pro?Met?Ile?Ile

225 230 235 240

Ala?Gly?Gly?Gly?Val?Leu?Tyr?Ser?Asp?Ala?Glu?Thr?Gln?Leu?Gln?Ala

245 250 255

Leu?Val?Glu?Gln?Thr?Gly?Ile?Pro?Val?Gly?Thr?Ser?Gln?Ala?Gly?Gly

260 265 270

Gly?Val?Leu?Ala?Trp?Asp?His?Ala?Gln?Asn?Leu?Gly?Gly?Val?Gly?Ala

275 280 285

Thr?Gly?Thr?Leu?Ala?Ala?Asn?Arg?Ile?Ala?Gly?Asp?Ala?Asp?Val?Ile

290 295 300

Ile?Gly?Ile?Gly?Thr?Arg?Tyr?Ser?Asp?Phe?Thr?Thr?Ala?Ser?Arg?Thr

305 310 315 320

Ala?Phe?Gln?Asn?Pro?Asp?Val?Thr?Phe?Ile?Asn?Ile?Asn?Val?Ala?Ser

325 330 335

Phe?Asp?Ala?Tyr?Lys?His?Gly?Thr?Gln?Leu?Pro?Val?Ile?Ala?Asp?Ala

340 345 350

Arg?Glu?Ala?Ile?Val?Glu?Leu?Ala?Glu?Ala?Leu?Gln?Gly?Phe?Thr?Val

355 360 365

Ala?Glu?Asp?Tyr?Ala?Gln?Arg?Ile?Ala?Lys?Glu?Lys?Ala?Ala?Trp?Asp

370 375 380

Ala?Glu?Val?Asp?Lys?Ser?Phe?Ala?Pro?Ser?Gly?Leu?Ala?Leu?Pro?Gly

385 390 395 400

Gln?Pro?Glu?Ile?Ile?Gly?Ala?Val?Gln?Ala?Ser?Thr?Ser?Glu?Lys?Asp

405 410 415

Val?Ile?Val?Gln?Ala?Ala?Gly?Ser?Leu?Pro?Gly?Asp?Leu?His?Lys?Leu

420 425 430

Trp?Arg?Val?Arg?Asp?Ala?Leu?Gly?Tyr?His?Val?Glu?Tyr?Ala?Phe?Ser

435 440 445

Cys?Met?Gly?Tyr?Glu?Ile?Ala?Gly?Gly?Ile?Gly?Ala?Lys?Arg?Gly?Leu

450 455 460

Asp?Ala?Ala?Gly?Asp?Asp?Arg?Asp?Val?Val?Ile?Met?Val?Gly?Asp?Gly

465 470 475 480

Ser?Tyr?Leu?Met?Leu?Asn?Thr?Glu?Leu?Val?Thr?Ala?Val?Ala?Glu?Gly

485 490 495

Ile?Lys?Val?Ile?Val?Val?Leu?Ile?Gln?Asn?His?Gly?Tyr?Ala?Ser?Ile

500 505 510

Gly?His?Leu?Ser?Glu?Thr?Val?Gly?Ser?Gln?Arg?Phe?Gly?Thr?Trp?Tyr

515 520 525

Arg?Glu?Tyr?Asp?Ala?Glu?Ala?Lys?Asn?Phe?Gln?Gly?Glu?Gln?Ile?Leu

530 535 540

Pro?Val?Asp?Leu?Ala?Met?Asn?Ala?Arg?Ser?Tyr?Gly?Met?Asp?Val?Ile

545 550 555 560

Glu?Val?Glu?Pro?Ser?Ala?Asn?Ala?Ile?Glu?Asp?Leu?Lys?Ala?Ala?Met

565 570 575

Ala?Thr?Ala?Lys?Ala?Ser?Glu?Lys?Ser?Thr?Phe?Ile?His?Ile?Asn?Ser

580 585 590

Asp?Pro?Leu?Ile?Tyr?Ala?Pro?Asp?Gly?Ala?Gly?Trp?Trp?Asp?Val?Pro

595 600 605

Val?Ser?Glu?Thr?Ser?Thr?Leu?Asp?Ser?Thr?Asn?Ala?Ala?Arg?Glu?Asp

610 615 620

Tyr?Leu?Lys?Asn?Gln?Ala?Leu?Gln?Arg?Pro?Leu?Leu?Gly

625 630 635

<210>231

<211>1142

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(1119)

<223>RXN01143

<400>231

atc?cca?gtt?gtc?acc?acc?ttg?atg?gct?ttg?ggt?act?ttc?cca?gag?tct 48

Ile?Pro?Val?Val?Thr?Thr?Leu?Met?Ala?Leu?Gly?Thr?Phe?Pro?Glu?Ser

1 5 10 15

cac?gag?ctg?cac?atg?ggt?atg?cca?ggc?atg?cat?ggc?act?gtg?tcc?gct 96

His?Glu?Leu?His?Met?Gly?Met?Pro?Gly?Met?His?Gly?Thr?Val?Ser?Ala

20 25 30

gtt?ggt?gca?ctg?cag?cgc?agc?gac?ctg?ctg?att?gct?atc?ggc?tcc?cgc 144

Val?Gly?Ala?Leu?Gln?Arg?Ser?Asp?Leu?Leu?Ile?Ala?Ile?Gly?Ser?Arg

35 40 45

ttt?gat?gac?cgc?gtc?acc?ggt?gac?gtt?gac?acc?ttc?gcg?cct?gac?gcc 192

Phe?Asp?Asp?Arg?Val?Thr?Gly?Asp?Val?Asp?Thr?Phe?Ala?Pro?Asp?Ala

50 55 60

aag?atc?att?cac?gcc?gac?att?gat?cct?gcc?gaa?atc?ggc?aag?atc?aag 240

Lys?Ile?Ile?His?Ala?Asp?Ile?Asp?Pro?Ala?Glu?Ile?Gly?Lys?Ile?Lys

65 70 75 80

cag?gtt?gag?gtt?cca?atc?gtg?ggc?gat?gcc?cgc?gaa?gtt?ctt?gct?cgt 288

Gln?Val?Glu?Val?Pro?Ile?Val?Gly?Asp?Ala?Arg?Glu?Val?Leu?Ala?Arg

85 90 95

ctg?ctg?gaa?acc?acc?aag?gca?agc?aag?gca?gag?acc?gag?gac?atc?tcc 336

Leu?Leu?Glu?Thr?Thr?Lys?Ala?Ser?Lys?Ala?Glu?Thr?Glu?Asp?Ile?Ser

100 105 110

gag?tgg?gtt?gac?tac?ctc?aag?ggc?ctc?aag?gca?cgt?ttc?ccg?cgt?ggc 384

Glu?Trp?Val?Asp?Tyr?Leu?Lys?Gly?Leu?Lys?Ala?Arg?Phe?Pro?Arg?Gly

115 120 125

tac?gac?gag?cag?cca?ggc?gat?ctg?ctg?gca?cca?cag?ttt?gtc?att?gaa 432

Tyr?Asp?Glu?Gln?Pro?Gly?Asp?Leu?Leu?Ala?Pro?Gln?Phe?Val?Ile?Glu

130 135 140

acc?ctg?tcc?aag?gaa?gtt?ggc?ccc?gac?gca?att?tac?tgc?gcc?ggc?gtt 480

Thr?Leu?Ser?Lys?Glu?Val?Gly?Pro?Asp?Ala?Ile?Tyr?Cys?Ala?Gly?Val

145 150 155 160

ggc?cag?cac?caa?atg?tgg?gca?gct?cag?ttc?gtt?gac?ttt?gaa?aag?cca 528

Gly?Gln?His?Gln?Met?Trp?Ala?Ala?Gln?Phe?Val?Asp?Phe?Glu?Lys?Pro

165 170 175

cgc?acc?tgg?ctc?aac?tcc?ggt?gga?ctg?ggc?acc?atg?ggc?tac?gca?gtt 576

Arg?Thr?Trp?Leu?Asn?Ser?Gly?Gly?Leu?Gly?Thr?Met?Gly?Tyr?Ala?Val

180 185 190

cct?gcg?gcc?ctt?gga?gca?aag?gct?ggc?gca?cct?gac?aag?gaa?gtc?tgg 624

Pro?Ala?Ala?Leu?Gly?Ala?Lys?Ala?Gly?Ala?Pro?Asp?Lys?Glu?Val?Trp

195 200 205

gct?atc?gac?ggc?gac?ggc?tgt?ttc?cag?atg?acc?aac?cag?gaa?ctc?acc 672

Ala?Ile?Asp?Gly?Asp?Gly?Cys?Phe?Gln?Met?Thr?Asn?Gln?Glu?Leu?Thr

210 215 220

acc?gcc?gca?gtt?gaa?ggt?ttc?ccc?att?aag?atc?gca?cta?atc?aac?aac 720

Thr?Ala?Ala?Val?Glu?Gly?Phe?Pro?Ile?Lys?Ile?Ala?Leu?Ile?Asn?Asn

225 230 235 240

gga?aaa?cct?ggg?gca?tgg?gtt?cgc?caa?tgg?cag?acc?cta?ttc?tat?gaa 768

Gly?Lys?Pro?Gly?Ala?Trp?Val?Arg?Gln?Trp?Gln?Thr?Leu?Phe?Tyr?Glu

245 250 255

gga?cgg?tac?tca?aat?act?aaa?ctt?cgt?aac?cag?ggc?gag?tac?atg?ccc 816

Gly?Arg?Tyr?Ser?Asn?Thr?Lys?Leu?Arg?Asn?Gln?Gly?Glu?Tyr?Met?Pro

260 265 270

gac?ttt?gtt?acc?ctt?tct?gag?gga?ctt?ggc?tgt?gtt?gcc?atc?cgc?gtc 864

Asp?Phe?Val?Thr?Leu?Ser?Glu?Gly?Leu?Gly?Cys?Val?Ala?Ile?Arg?Val

275 280 285

acc?aaa?gcg?gag?gaa?gta?ctg?cca?gcc?atc?caa?aag?gct?cga?gag?atc 912

Thr?Lys?Ala?Glu?Glu?Val?Leu?Pro?Ala?Ile?Gln?Lys?Ala?Arg?Glu?Ile

290 295 300

aac?gac?cgc?cca?gta?gtc?atc?gac?ttc?atc?gtc?ggt?gaa?gac?gca?cag 960

Asn?Asp?Arg?Pro?Val?Val?Ile?Asp?Phe?Ile?Val?Gly?Glu?Asp?Ala?Gln

305 310 315 320

gta?tgg?cca?atg?gtg?tct?gct?gga?tca?tcc?aac?tcc?gat?atc?cag?tac 1008

Val?Trp?Pro?Met?Val?Ser?Ala?Gly?Ser?Ser?Asn?Ser?Asp?Ile?Gln?Tyr

325 330 335

gca?ctc?gga?ttg?cgc?cca?ttc?ttt?gat?ggt?gat?gaa?tct?gca?gca?gaa 1056

Ala?Leu?Gly?Leu?Arg?Pro?Phe?Phe?Asp?Gly?Asp?Glu?Ser?Ala?Ala?Glu

340 345 350

gat?cct?gcc?gac?att?cac?gaa?gcc?gtc?agc?gac?att?gat?gcc?gcc?gtt 1104

Asp?Pro?Ala?Asp?Ile?His?Glu?Ala?Val?Ser?Asp?Ile?Asp?Ala?Ala?Val

355 360 365

gaa?tcg?acc?gag?gca?taaggagaga?cccaagatgg?cta 1142

Glu?Ser?Thr?Glu?Ala

370

<210>232

<211>373

<212>PRT

＜213〉Corynebacterium glutamicum

<400>232

Ile?Pro?Val?Val?Thr?Thr?Leu?Met?Ala?Leu?Gly?Thr?Phe?Pro?Glu?Ser

1 5 10 15

His?Glu?Leu?His?Met?Gly?Met?Pro?Gly?Met?His?Gly?Thr?Val?Ser?Ala

20 25 30

Val?Gly?Ala?Leu?Gln?Arg?Ser?Asp?Leu?Leu?Ile?Ala?Ile?Gly?Ser?Arg

35 40 45

Phe?Asp?Asp?Arg?Val?Thr?Gly?Asp?Val?Asp?Thr?Phe?Ala?Pro?Asp?Ala

50 55 60

Lys?Ile?Ile?His?Ala?Asp?Ile?Asp?Pro?Ala?Glu?Ile?Gly?Lys?Ile?Lys

65 70 75 80

Gln?Val?Glu?Val?Pro?Ile?Val?Gly?Asp?Ala?Arg?Glu?Val?Leu?Ala?Arg

85 90 95

Leu?Leu?Glu?Thr?Thr?Lys?Ala?Ser?Lys?Ala?Glu?Thr?Glu?Asp?Ile?Ser

100 105 110

Glu?Trp?Val?Asp?Tyr?Leu?Lys?Gly?Leu?Lys?Ala?Arg?Phe?Pro?Arg?Gly

115 120 125

Tyr?Asp?Glu?Gln?Pro?Gly?Asp?Leu?Leu?Ala?Pro?Gln?Phe?Val?Ile?Glu

130 135 140

Thr?Leu?Ser?Lys?Glu?Val?Gly?Pro?Asp?Ala?Ile?Tyr?Cys?Ala?Gly?Val

145 150 155 160

Gly?Gln?His?Gln?Met?Trp?Ala?Ala?Gln?Phe?Val?Asp?Phe?Glu?Lys?Pro

165 170 175

Arg?Thr?Trp?Leu?Asn?Ser?Gly?Gly?Leu?Gly?Thr?Met?Gly?Tyr?Ala?Val

180 185 190

Pro?Ala?Ala?Leu?Gly?Ala?Lys?Ala?Gly?Ala?Pro?Asp?Lys?Glu?Val?Trp

195 200 205

Ala?Ile?Asp?Gly?Asp?Gly?Cys?Phe?Gln?Met?Thr?Asn?Gln?Glu?Leu?Thr

210 215 220

Thr?Ala?Ala?Val?Glu?Gly?Phe?Pro?Ile?Lys?Ile?Ala?Leu?Ile?Asn?Asn

225 230 235 240

Gly?Lys?Pro?Gly?Ala?Trp?Val?Arg?Gln?Trp?Gln?Thr?Leu?Phe?Tyr?Glu

245 250 255

Gly?Arg?Tyr?Ser?Asn?Thr?Lys?Leu?Arg?Asn?Gln?Gly?Glu?Tyr?Met?Pro

260 265 270

Asp?Phe?Val?Thr?Leu?Ser?Glu?Gly?Leu?Gly?Cys?Val?Ala?Ile?Arg?Val

275 280 285

Thr?Lys?Ala?Glu?Glu?Val?Leu?Pro?Ala?Ile?Gln?Lys?Ala?Arg?Glu?Ile

290 295 300

Asn?Asp?Arg?Pro?Val?Val?Ile?Asp?Phe?Ile?Val?Gly?Glu?Asp?Ala?Gln

305 310 315 320

Val?Trp?Pro?Met?Val?Ser?Ala?Gly?Ser?Ser?Asn?Ser?Asp?Ile?Gln?Tyr

325 330 335

Ala?Leu?Gly?Leu?Arg?Pro?Phe?Phe?Asp?Gly?Asp?Glu?Ser?Ala?Ala?Glu

340 345 350

Asp?Pro?Ala?Asp?Ile?His?Glu?Ala?Val?Ser?Asp?Ile?Asp?Ala?Ala?Val

355 360 365

Glu?Ser?Thr?Glu?Ala

370

<210>233

<211>793

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(793)

<223>RXN01146

<400>233

tatttagtaa?aggagccaga?aagtcgtgaa?tgtggcagct?tctcaacagc?ccactcccgc?60

cacggttgca?agccgtggtc?gatccgccgc?ccctgagcgg?atg?aca?ggt?gca?aag 115

Met?Thr?Gly?Ala?Lys

1 5

gca?att?gtt?cga?tcg?ctc?gag?gag?ctt?aac?gcc?gac?atc?gtg?ttc?ggt 163

Ala?Ile?Val?Arg?Ser?Leu?Glu?Glu?Leu?Asn?Ala?Asp?Ile?Val?Phe?Gly

10 15 20

att?cct?ggt?ggt?gcg?gtg?cta?ccg?gtg?tat?gac?ccg?ctc?tat?tcc?tcc 211

Ile?Pro?Gly?Gly?Ala?Val?Leu?Pro?Val?Tyr?Asp?Pro?Leu?Tyr?Ser?Ser

25 30 35

aca?aag?gtg?cgc?cac?gtc?ttg?gtg?cgc?cac?gag?cag?ggc?gca?ggc?cac 259

Thr?Lys?Val?Arg?His?Val?Leu?Val?Arg?His?Glu?Gln?Gly?Ala?Gly?His

40 45 50

gca?gca?acc?ggc?tac?gcg?cag?gtt?act?gga?cgc?gtt?ggc?gtc?tgc?att 307

Ala?Ala?Thr?Gly?Tyr?Ala?Gln?Val?Thr?Gly?Arg?Val?Gly?Val?Cys?Ile

55 60 65

gca?acc?tct?ggc?cca?gga?gca?acc?aac?ttg?gtt?acc?cca?atc?gct?gat 355

Ala?Thr?Ser?Gly?Pro?Gly?Ala?Thr?Asn?Leu?Val?Thr?Pro?Ile?Ala?Asp

70 75 80 85

gca?aac?ttg?gac?tcc?gtt?ccc?atg?gtt?gcc?atc?acc?ggc?cag?gtc?gga 403

Ala?Asn?Leu?Asp?Ser?Val?Pro?Met?Val?Ala?Ile?Thr?Gly?Gln?Val?Gly

90 95 100

agt?ggc?ctg?ctg?ggt?acc?gac?gct?ttc?cag?gaa?gcc?gat?atc?cgc?ggc 451

Ser?Gly?Leu?Leu?Gly?Thr?Asp?Ala?Phe?Gln?Glu?Ala?Asp?Ile?Arg?Gly

105 110 115

atc?acc?atg?cca?gtg?acc?aag?cac?aac?ttc?atg?gtc?acc?aac?cct?aac 499

Ile?Thr?Met?Pro?Val?Thr?Lys?His?Asn?Phe?Met?Val?Thr?Asn?Pro?Asn

120 125 130

gac?att?cca?cag?gca?ttg?gct?gag?gca?ttc?cac?ctc?gcg?att?act?ggt 547

Asp?Ile?Pro?Gln?Ala?Leu?Ala?Glu?Ala?Phe?His?Leu?Ala?Ile?Thr?Gly

135 140 145

cgc?cct?ggc?cct?gtt?ctg?gtg?gat?att?cct?aag?gat?gtc?cag?aac?gct 595

Arg?Pro?Gly?Pro?Val?Leu?Val?Asp?Ile?Pro?Lys?Asp?Val?Gln?Asn?Ala

150 155 160 165

gaa?ttg?gat?ttc?gtc?tgg?cca?cca?aag?atc?gac?ctg?cca?ggc?tac?cgc 643

Glu?Leu?Asp?Phe?Val?Trp?Pro?Pro?Lys?Ile?Asp?Leu?Pro?Gly?Tyr?Arg

170 175 180

cca?gtt?tca?aca?cca?cat?gct?cgc?cag?atc?gag?cag?gca?gtc?aag?ctg 691

Pro?Val?Ser?Thr?Pro?His?Ala?Arg?Gln?Ile?Glu?Gln?Ala?Val?Lys?Leu

185 190 195

atc?ggt?gag?gcc?aag?aag?ccc?gtc?ctt?tac?gtt?ggt?ggt?ggc?gta?atc 739

Ile?Gly?Glu?Ala?Lys?Lys?Pro?Val?Leu?Tyr?Val?Gly?Gly?Gly?Val?Ile

200 205 210

aag?gct?gac?gca?cac?gaa?gag?ctt?cgt?gcg?ttc?gct?gag?tac?acc?ggc 787

Lys?Ala?Asp?Ala?His?Glu?Glu?Leu?Arg?Ala?Phe?Ala?Glu?Tyr?Thr?Gly

215 220 225

atc?cca 793

Ile?Pro

230

<210>234

<211>231

<212>PRT

＜213〉Corynebacterium glutamicum

<400>234

Met?Thr?Gly?Ala?Lys?Ala?Ile?Val?Arg?Ser?Leu?Glu?Glu?Leu?Asn?Ala

1 5 10 15

Asp?Ile?Val?Phe?Gly?Ile?Pro?Gly?Gly?Ala?Val?Leu?Pro?Val?Tyr?Asp

20 25 30

Pro?Leu?Tyr?Ser?Ser?Thr?Lys?Val?Arg?His?Val?Leu?Val?Arg?His?Glu

35 40 45

Gln?Gly?Ala?Gly?His?Ala?Ala?Thr?Gly?Tyr?Ala?Gln?Val?Thr?Gly?Arg

50 55 60

Val?Gly?Val?Cys?Ile?Ala?Thr?Ser?Gly?Pro?Gly?Ala?Thr?Asn?Leu?Val

65 70 75 80

Thr?Pro?Ile?Ala?Asp?Ala?Asn?Leu?Asp?Ser?Val?Pro?Met?Val?Ala?Ile

85 90 95

Thr?Gly?Gln?Val?Gly?Ser?Gly?Leu?Leu?Gly?Thr?Asp?Ala?Phe?Gln?Glu

100 105 110

Ala?Asp?Ile?Arg?Gly?Ile?Thr?Met?Pro?Val?Thr?Lys?His?Asn?Phe?Met

115 120 125

Val?Thr?Asn?Pro?Asn?Asp?Ile?Pro?Gln?Ala?Leu?Ala?Glu?Ala?Phe?His

130 135 140

Leu?Ala?Ile?Thr?Gly?Arg?Pro?Gly?Pro?Val?Leu?Val?Asp?Ile?Pro?Lys

145 150 155 160

Asp?Val?Gln?Asn?Ala?Glu?Leu?Asp?Phe?Val?Trp?Pro?Pro?Lys?Ile?Asp

165 170 175

Leu?Pro?Gly?Tyr?Arg?Pro?Val?Ser?Thr?Pro?His?Ala?Arg?Gln?Ile?Glu

180 185 190

Gln?Ala?Val?Lys?Leu?Ile?Gly?Glu?Ala?Lys?Lys?Pro?Val?Leu?Tyr?Val

195 200 205

Gly?Gly?Gly?Val?Ile?Lys?Ala?Asp?Ala?His?Glu?Glu?Leu?Arg?Ala?Phe

210 215 220

Ala?Glu?Tyr?Thr?Gly?Ile?Pro

225 230

<210>235

<211>639

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(616)

<223>RXN01144

<400>235

ggtgatgaat?ctgcagcaga?agatcctgcc?gacattcacg?aagccgtcag?cgacattgat?60

gccgccgttg?aatcgaccga?ggcataagga?gagacccaag?atg?gct?aat?tct?gac 115

Met?Ala?Asn?Ser?Asp

1 5

gtc?acc?cgc?cac?atc?ctg?tcc?gta?ctc?gtt?cag?gac?gta?gac?gga?atc 163

Val?Thr?Arg?His?Ile?Leu?Ser?Val?Leu?Val?Gln?Asp?Val?Asp?Gly?Ile

10 15 20

att?tcc?cgc?gta?tca?ggt?atg?ttc?acc?cga?cgc?gca?ttc?aac?ctc?gtg 211

Ile?Ser?Arg?Val?Ser?Gly?Met?Phe?Thr?Arg?Arg?Ala?Phe?Asn?Leu?Val

25 30 35

ttc?ctc?gtg?tct?gca?aag?acc?gaa?aca?cac?ggc?atc?aac?cgc?atc?acg 259

Phe?Leu?Val?Ser?Ala?Lys?Thr?Glu?Thr?His?Gly?Ile?Asn?Arg?Ile?Thr

40 45 50

gtt?gtt?gtc?gac?gcc?gac?gag?ctc?aac?att?gag?cag?atc?acc?aag?cag 307

Val?Val?Val?Asp?Ala?Asp?Glu?Leu?Asn?Ile?Glu?Gln?Ile?Thr?Lys?Gln

55 60 65

ctc?aac?aag?ctg?atc?ccc?gtg?ctc?aaa?gtc?gtg?cga?ctt?gat?gaa?gag 355

Leu?Asn?Lys?Leu?Ile?Pro?Val?Leu?Lys?Val?Val?Arg?Leu?Asp?Glu?Glu

70 75 80 85

acc?act?atc?gcc?cgc?gca?atc?atg?ctg?gtt?aag?gtc?tct?gcg?gac?agc 403

Thr?Thr?Ile?Ala?Arg?Ala?Ile?Met?Leu?Val?Lys?Val?Ser?Ala?Asp?Ser

90 95 100

acc?aac?cgt?ccg?cag?atc?gtc?gac?gcc?gcg?aac?atc?ttc?cgc?gcc?cga 451

Thr?Asn?Arg?Pro?Gln?Ile?Val?Asp?Ala?Ala?Asn?Ile?Phe?Arg?Ala?Arg

105 110 115

gtc?gtc?gac?gtg?gct?cca?gac?tct?gtg?gtt?att?gaa?tcc?aca?ggc?acc 499

Val?Val?Asp?Val?Ala?Pro?Asp?Ser?Val?Val?Ile?Glu?Ser?Thr?Gly?Thr

120 125 130

cca?ggc?aag?ctc?cgc?gca?ctg?ctt?gac?gtg?atg?gaa?cca?ttc?gga?atc 547

Pro?Gly?Lys?Leu?Arg?Ala?Leu?Leu?Asp?Val?Met?Glu?Pro?Phe?Gly?Ile

135 140 145

cgc?gaa?ctg?atc?caa?tcc?gga?cag?att?gca?ctc?aac?cgc?ggt?ccg?aag 595

Arg?Glu?Leu?Ile?Gln?Ser?Gly?Gln?Ile?Ala?Leu?Asn?Arg?Gly?Pro?Lys

150 155 160 165

acc?atg?gct?ccg?gcc?aag?atc?taaacagcaa?ttaatctgat?tgc 639

Thr?Met?Ala?Pro?Ala?Lys?Ile

170

<210>236

<211>172

<212>PRT

＜213〉Corynebacterium glutamicum

<400>236

Met?Ala?Asn?Ser?Asp?Val?Thr?Arg?His?Ile?Leu?Ser?Val?Leu?Val?Gln

1 5 10 15

Asp?Val?Asp?Gly?Ile?Ile?Ser?Arg?Val?Ser?Gly?Met?Phe?Thr?Arg?Arg

20 25 30

Ala?Phe?Asn?Leu?Val?Phe?Leu?Val?Ser?Ala?Lys?Thr?Glu?Thr?His?Gly

35 40 45

Ile?Asn?Arg?Ile?Thr?Val?Val?Val?Asp?Ala?Asp?Glu?Leu?Asn?Ile?Glu

50 55 60

Gln?Ile?Thr?Lys?Gln?Leu?Asn?Lys?Leu?Ile?Pro?Val?Leu?Lys?Val?Val

65 70 75 80

Arg?Leu?Asp?Glu?Glu?Thr?Thr?Ile?Ala?Arg?Ala?Ile?Met?Leu?Val?Lys

85 90 95

Val?Ser?Ala?Asp?Ser?Thr?Asn?Arg?Pro?Gln?Ile?Val?Asp?Ala?Ala?Asn

100 105 110

Ile?Phe?Arg?Ala?Arg?Val?Val?Asp?Val?Ala?Pro?Asp?Ser?Val?Val?Ile

115 120 125

Glu?Ser?Thr?Gly?Thr?Pro?Gly?Lys?Leu?Arg?Ala?Leu?Leu?Asp?Val?Met

130 135 140

Glu?Pro?Phe?Gly?Ile?Arg?Glu?Leu?Ile?Gln?Ser?Gly?Gln?Ile?Ala?Leu

145 150 155 160

Asn?Arg?Gly?Pro?Lys?Thr?Met?Ala?Pro?Ala?Lys?Ile

165 170

<210>237

<211>897

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(874)

<223>RXA02474

<400>237

tgctggtcta?ttgtggcgac?cgagggcctt?tgaaggttcg?acaaactgta?taaggccttg?60

aatcttgaga?atttattttg?aggaagcaag?aggaagtgtc?atg?agc?aaa?gtt?gca 115

Met?Ser?Lys?Val?Ala

1 5

atg?gtt?acc?ggt?ggt?gca?caa?ggc?atc?ggt?cgt?gga?att?tca?gag?aag 163

Met?Val?Thr?Gly?Gly?Ala?Gln?Gly?Ile?Gly?Arg?Gly?Ile?Ser?Glu?Lys

10 15 20

ctg?gca?gca?gat?ggt?ttc?gat?att?gcc?gta?gcc?gac?ctg?cca?caa?cag 211

Leu?Ala?Ala?Asp?Gly?Phe?Asp?Ile?Ala?Val?Ala?Asp?Leu?Pro?Gln?Gln

25 30 35

gaa?gaa?caa?gct?gca?gag?acc?atc?aag?ttg?att?gaa?gct?gca?ggt?caa 259

Glu?Glu?Gln?Ala?Ala?Glu?Thr?Ile?Lys?Leu?Ile?Glu?Ala?Ala?Gly?Gln

40 45 50

aag?gct?gta?ttc?gtt?gga?tta?gat?gtc?acc?gat?aag?gct?aat?ttc?gac 307

Lys?Ala?Val?Phe?Val?Gly?Leu?Asp?Val?Thr?Asp?Lys?Ala?Asn?Phe?Asp

55 60 65

agt?gca?att?gat?gag?gca?gca?gag?aaa?ctt?ggc?ggc?ttc?gat?gtg?cta 355

Ser?Ala?Ile?Asp?Glu?Ala?Ala?Glu?Lys?Leu?Gly?Gly?Phe?Asp?Val?Leu

70 75 80 85

gta?aac?aac?gcc?ggc?atc?gca?caa?att?aag?cca?ctt?ctg?gaa?gtc?acc 403

Val?Asn?Asn?Ala?Gly?Ile?Ala?Gln?Ile?Lys?Pro?Leu?Leu?Glu?Val?Thr

90 95 100

gaa?gaa?gac?cta?aag?cag?atc?tac?tcc?gtg?aac?gtt?ttt?agc?gta?ttt 451

Glu?Glu?Asp?Leu?Lys?Gln?Ile?Tyr?Ser?Val?Asn?Val?Phe?Ser?Val?Phe

105 110 115

ttt?ggt?att?caa?gca?gca?tcc?cga?aag?ttc?gat?gag?ctt?ggc?gta?aaa 499

Phe?Gly?Ile?Gln?Ala?Ala?Ser?Arg?Lys?Phe?Asp?Glu?Leu?Gly?Val?Lys

120 125 130

ggc?aag?atc?atc?aac?gct?gca?tca?atc?gct?gct?atc?caa?ggt?ttc?cca 547

Gly?Lys?Ile?Ile?Asn?Ala?Ala?Ser?Ile?Ala?Ala?Ile?Gln?Gly?Phe?Pro

135 140 145

atc?ttg?agc?gcc?tac?tcc?acc?acc?aaa?ttc?gcg?gtt?cgt?ggc?ctc?acc 595

Ile?Leu?Ser?Ala?Tyr?Ser?Thr?Thr?Lys?Phe?Ala?Val?Arg?Gly?Leu?Thr

150 155 160 165

cag?gct?gct?gcg?caa?gaa?ctc?gca?ccc?aag?ggt?cac?acc?gtg?aat?gcc 643

Gln?Ala?Ala?Ala?Gln?Glu?Leu?Ala?Pro?Lys?Gly?His?Thr?Val?Asn?Ala

170 175 180

tac?gca?cct?ggc?atc?gtg?ggc?acc?gga?atg?tgg?gag?caa?atc?gat?gcc 691

Tyr?Ala?Pro?Gly?Ile?Val?Gly?Thr?Gly?Met?Trp?Glu?Gln?Ile?Asp?Ala

185 190 195

gag?ctt?tcc?aag?atc?aac?ggc?aag?cca?atc?ggt?gag?aac?ttc?aag?gag 739

Glu?Leu?Ser?Lys?Ile?Asn?Gly?Lys?Pro?Ile?Gly?Glu?Asn?Phe?Lys?Glu

200 205 210

tac?tcc?tcc?tca?atc?gca?ttg?ggc?cga?cca?tca?gta?cct?gag?gat?gta 787

Tyr?Ser?Ser?Ser?Ile?Ala?Leu?Gly?Arg?Pro?Ser?Val?Pro?Glu?Asp?Val

215 220 225

gcc?ggt?ctg?gtt?tcg?ttc?ctg?gct?tct?gaa?aac?tcc?aac?tac?atc?acc 835

Ala?Gly?Leu?Val?Ser?Phe?Leu?Ala?Ser?Glu?Asn?Ser?Asn?Tyr?Ile?Thr

230 235 240 245

gga?cag?gtc?atg?ctt?gtc?gac?ggc?ggc?atg?ctc?tac?aac?taggggttgc 884

Gly?Gln?Val?Met?Leu?Val?Asp?Gly?Gly?Met?Leu?Tyr?Asn

250 255

tttcccgcac?tca 897

<210>238

<211>258

<212>PRT

＜213〉Corynebacterium glutamicum

<400>238

Met?Ser?Lys?Val?Ala?Met?Val?Thr?Gly?Gly?Ala?Gln?Gly?Ile?Gly?Arg

1 5 10 15

Gly?Ile?Ser?Glu?Lys?Leu?Ala?Ala?Asp?Gly?Phe?Asp?Ile?Ala?Val?Ala

20 25 30

Asp?Leu?Pro?Gln?Gln?Glu?Glu?Gln?Ala?Ala?Glu?Thr?Ile?Lys?Leu?Ile

35 40 45

Glu?Ala?Ala?Gly?Gln?Lys?Ala?Val?Phe?Val?Gly?Leu?Asp?Val?Thr?Asp

50 55 60

Lys?Ala?Asn?Phe?Asp?Ser?Ala?Ile?Asp?Glu?Ala?Ala?Glu?Lys?Leu?Gly

65 70 75 80

Gly?Phe?Asp?Val?Leu?Val?Asn?Asn?Ala?Gly?Ile?Ala?Gln?Ile?Lys?Pro

85 90 95

Leu?Leu?Glu?Val?Thr?Glu?Glu?Asp?Leu?Lys?Gln?Ile?Tyr?Ser?Val?Asn

100 105 110

Val?Phe?Ser?Val?Phe?Phe?Gly?Ile?Gln?Ala?Ala?Ser?Arg?Lys?Phe?Asp

115 120 125

Glu?Leu?Gly?Val?Lys?Gly?Lys?Ile?Ile?Asn?Ala?Ala?Ser?Ile?Ala?Ala

130 135 140

Ile?Gln?Gly?Phe?Pro?Ile?Leu?Ser?Ala?Tyr?Ser?Thr?Thr?Lys?Phe?Ala

145 150 155 160

Val?Arg?Gly?Leu?Thr?Gln?Ala?Ala?Ala?Gln?Glu?Leu?Ala?Pro?Lys?Gly

165 170 175

His?Thr?Val?Asn?Ala?Tyr?Ala?Pro?Gly?Ile?Val?Gly?Thr?Gly?Met?Trp

180 185 190

Glu?Gln?Ile?Asp?Ala?Glu?Leu?Ser?Lys?Ile?Asn?Gly?Lys?Pro?Ile?Gly

195 200 205

Glu?Asn?Phe?Lys?Glu?Tyr?Ser?Ser?Ser?Ile?Ala?Leu?Gly?Arg?Pro?Ser

210 215 220

Val?Pro?Glu?Asp?Val?Ala?Gly?Leu?Val?Ser?Phe?Leu?Ala?Ser?Glu?Asn

225 230 235 240

Ser?Asn?Tyr?Ile?Thr?Gly?Gln?Val?Met?Leu?Val?Asp?Gly?Gly?Met?Leu

245 250 255

Tyr?Asn

<210>239

<211>876

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(853)

<223>RXA02453

<400>239

aaccaacaaa?ggtcatctca?accggcttaa?gaaaattctg?ccagctttct?gctgattgaa?60

tcgtgccagc?tcagggcata?tctcacctaa?agtaaacacc?atg?aaa?tca?atc?ttc 115

Met?Lys?Ser?Ile?Phe

1 5

att?tcc?ggt?gcg?gcg?aac?gga?att?ggc?aaa?gct?gtg?gcg?ttg?aaa?ttt 163

Ile?Ser?Gly?Ala?Ala?Asn?Gly?Ile?Gly?Lys?Ala?Val?Ala?Leu?Lys?Phe

10 15 20

ctt?cac?gaa?ggt?tgg?ctc?gtt?gga?gcc?tac?gac?ctc?gcg?gaa?atc?acc 211

Leu?His?Glu?Gly?Trp?Leu?Val?Gly?Ala?Tyr?Asp?Leu?Ala?Glu?Ile?Thr

25 30 35

tac?tca?cac?ccc?aat?ctt?cgc?tgg?ggc?tac?ctc?aat?gtt?cga?cag?tcc 259

Tyr?Ser?His?Pro?Asn?Leu?Arg?Trp?Gly?Tyr?Leu?Asn?Val?Arg?Gln?Ser

40 45 50

gag?tcg?tgg?gac?aaa?gcc?cta?gaa?gac?ttt?gcg?acg?cac?acc?gga?ggc 307

Glu?Ser?Trp?Asp?Lys?Ala?Leu?Glu?Asp?Phe?Ala?Thr?His?Thr?Gly?Gly

55 60 65

acc?atc?gat?gtg?gtg?gac?aat?aat?gcc?ggc?gta?att?att?gag?gga?ccg 355

Thr?Ile?Asp?Val?Val?Asp?Asn?Asn?Ala?Gly?Val?Ile?Ile?Glu?Gly?Pro

70 75 80 85

ctg?cag?gac?gca?gag?gag?ggg?agc?gtc?gac?aag?ctt?ctt?gca?atc?aac 403

Leu?Gln?Asp?Ala?Glu?Glu?Gly?Ser?Val?Asp?Lys?Leu?Leu?Ala?Ile?Asn

90 95 100

gtc?aat?ggc?gtg?act?ctt?ggt?gcc?cgc?gcc?gct?cat?cct?tat?ttg?gcg 451

Val?Asn?Gly?Val?Thr?Leu?Gly?Ala?Arg?Ala?Ala?His?Pro?Tyr?Leu?Ala

105 110 115

cgc?acg?ccg?ggc?gcc?cag?ttg?tta?aac?atg?tcc?tcg?gcg?tcg?gcg?gtg 499

Arg?Thr?Pro?Gly?Ala?Gln?Leu?Leu?Asn?Met?Ser?Ser?Ala?Ser?Ala?Val

120 125 130

tac?ggg?cag?ccc?cag?atc?gcg?gtg?tat?tcg?gct?tcg?aag?ttt?tac?gtc 547

Tyr?Gly?Gln?Pro?Gln?Ile?Ala?Val?Tyr?Ser?Ala?Ser?Lys?Phe?Tyr?Val

135 140 145

gca?ggt?ctt?act?gag?gcg?ctg?aat?ttg?gag?tgg?cgg?aaa?gac?gat?att 595

Ala?Gly?Leu?Thr?Glu?Ala?Leu?Asn?Leu?Glu?Trp?Arg?Lys?Asp?Asp?Ile

150 155 160 165

cgc?gtg?gtc?gat?gtt?tgg?cct?ttg?tgg?gcg?aaa?acc?gat?ttg?gtg?aac 643

Arg?Val?Val?Asp?Val?Trp?Pro?Leu?Trp?Ala?Lys?Thr?Asp?Leu?Val?Asn

170 175 180

ggc?gtg?aag?gct?aag?tca?ctg?aag?cgt?ttg?ggt?gtc?cgg?atc?act?ccg 691

Gly?Val?Lys?Ala?Lys?Ser?Leu?Lys?Arg?Leu?Gly?Val?Arg?Ile?Thr?Pro

185 190 195

gaa?cag?gtg?gca?cag?gcg?gta?tgg?gat?gcg?gtg?cat?ccg?aaa?tct?cgg 739

Glu?Gln?Val?Ala?Gln?Ala?Val?Trp?Asp?Ala?Val?His?Pro?Lys?Ser?Arg

200 205 210

tgg?gcg?aag?gga?aag?gtg?cat?cac?ggg?gtg?tca?aag?ttg?gat?aag?gcg 787

Trp?Ala?Lys?Gly?Lys?Val?His?His?Gly?Val?Ser?Lys?Leu?Asp?Lys?Ala

215 220 225

ctg?tat?ctc?atg?aaa?tct?ctg?tcg?cct?gat?cgg?gta?gcg?atg?tgt?ttt 835

Leu?Tyr?Leu?Met?Lys?Ser?Leu?Ser?Pro?Asp?Arg?Val?Ala?Met?Cys?Phe

230 235 240 245

gcg?cga?cta?atc?gcc?gga?taaatgaatt?gattatttta?ggc 876

Ala?Arg?Leu?Ile?Ala?Gly

250

<210>240

<211>251

<212>PRT

＜213〉Corynebacterium glutamicum

<400>240

Met?Lys?Ser?Ile?Phe?Ile?Ser?Gly?Ala?Ala?Asn?Gly?Ile?Gly?Lys?Ala

1 5 10 15

Val?Ala?Leu?Lys?Phe?Leu?His?Glu?Gly?Trp?Leu?Val?Gly?Ala?Tyr?Asp

20 25 30

Leu?Ala?Glu?Ile?Thr?Tyr?Ser?His?Pro?Asn?Leu?Arg?Trp?Gly?Tyr?Leu

35 40 45

Asn?Val?Arg?Gln?Ser?Glu?Ser?Trp?Asp?Lys?Ala?Leu?Glu?Asp?Phe?Ala

50 55 60

Thr?His?Thr?Gly?Gly?Thr?Ile?Asp?Val?Val?Asp?Asn?Asn?Ala?Gly?Val

65 70 75 80

Ile?Ile?Glu?Gly?Pro?Leu?Gln?Asp?Ala?Glu?Glu?Gly?Ser?Val?Asp?Lys

85 90 95

Leu?Leu?Ala?Ile?Asn?Val?Asn?Gly?Val?Thr?Leu?Gly?Ala?Arg?Ala?Ala

100 105 110

His?Pro?Tyr?Leu?Ala?Arg?Thr?Pro?Gly?Ala?Gln?Leu?Leu?Asn?Met?Ser

115 120 125

Ser?Ala?Ser?Ala?Val?Tyr?Gly?Gln?Pro?Gln?Ile?Ala?Val?Tyr?Ser?Ala

130 135 140

Ser?Lys?Phe?Tyr?Val?Ala?Gly?Leu?Thr?Glu?Ala?Leu?Asn?Leu?Glu?Trp

145 150 155 160

Arg?Lys?Asp?Asp?Ile?Arg?Val?Val?Asp?Val?Trp?Pro?Leu?Trp?Ala?Lys

165 170 175

Thr?Asp?Leu?Val?Asn?Gly?Val?Lys?Ala?Lys?Ser?Leu?Lys?Arg?Leu?Gly

180 185 190

Val?Arg?Ile?Thr?Pro?Glu?Gln?Val?Ala?Gln?Ala?Val?Trp?Asp?Ala?Val

195 200 205

His?Pro?Lys?Ser?Arg?Trp?Ala?Lys?Gly?Lys?Val?His?His?Gly?Val?Ser

210 215 220

Lys?Leu?Asp?Lys?Ala?Leu?Tyr?Leu?Met?Lys?Ser?Leu?Ser?Pro?Asp?Arg

225 230 235 240

Val?Ala?Met?Cys?Phe?Ala?Arg?Leu?Ile?Ala?Gly

245 250

<210>241

<211>1140

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1117)

<223>RXS01758

<400>241

cccccttatt?cagagtgatg?gtctaccgga?gaagtaccca?gaccaatagc?atcgaccaac?60

gatagcgcgc?tcagaagttc?tttagtgaaa?gcagaaccaa?atg?ccc?aaa?tac?att 115

Met?Pro?Lys?Tyr?Ile

1 5

gcc?atg?cag?gta?tcc?gaa?tcc?ggt?gca?ccg?tta?gcc?gcg?aat?ctc?gtg 163

Ala?Met?Gln?Val?Ser?Glu?Ser?Gly?Ala?Pro?Leu?Ala?Ala?Asn?Leu?Val

10 15 20

caa?cct?gct?ccg?ttg?aaa?tcg?agg?gaa?gtc?cgc?gtg?gaa?atc?gct?gct 211

Gln?Pro?Ala?Pro?Leu?Lys?Ser?Arg?Glu?Val?Arg?Val?Glu?Ile?Ala?Ala

25 30 35

agt?ggt?gtg?tgc?cat?gca?gat?att?ggc?acg?gca?gca?gca?tcg?ggg?aag 259

Ser?Gly?Val?Cys?His?Ala?Asp?Ile?Gly?Thr?Ala?Ala?Ala?Ser?Gly?Lys

40 45 50

cac?act?gtt?ttt?cct?gtt?acc?cct?ggt?cat?gag?att?gca?gga?acc?atc 307

His?Thr?Val?Phe?Pro?Val?Thr?Pro?Gly?His?Glu?Ile?Ala?Gly?Thr?Ile

55 60 65

gcg?gaa?att?ggt?gaa?aac?gta?tct?cgg?tgg?acg?gtt?ggt?gat?cgc?gtt 355

Ala?Glu?Ile?Gly?Glu?Asn?Val?Ser?Arg?Trp?Thr?Val?Gly?Asp?Arg?Val

70 75 80 85

gca?atc?ggt?tgg?ttt?ggt?ggc?aat?tgc?ggt?gac?tgc?gct?ttt?tgt?cgt 403

Ala?Ile?Gly?Trp?Phe?Gly?Gly?Asn?Cys?Gly?Asp?Cys?Ala?Phe?Cys?Arg

90 95 100

gca?ggt?gat?cct?gtg?cat?tgc?aga?gag?cgg?aag?att?cct?ggc?gtt?tct 451

Ala?Gly?Asp?Pro?Val?His?Cys?Arg?Glu?Arg?Lys?Ile?Pro?Gly?ValSer

105 110 115

tat?gcg?ggt?ggt?tgg?gca?cag?aat?att?gtt?gtt?cca?gcg?gag?gct?ctt 499

Tyr?Ala?Gly?Gly?Trp?Ala?Gln?Asn?Ile?Val?Val?Pro?Ala?Glu?Ala?Leu

120 125 130

gct?gcg?att?cca?gat?ggc?atg?gac?ttt?tac?gag?ccc?gcc?ccg?atg?ggc 547

Ala?Ala?Ile?Pro?Asp?Gly?Met?Asp?Phe?Tyr?Glu?Pro?Ala?Pro?Met?Gly

135 140 145

tgc?gca?ggt?gtg?aca?aca?ttc?aat?gcg?ttg?cga?aac?ctg?aag?ctg?gat 595

Cys?Ala?Gly?Val?Thr?Thr?Phe?Asn?Ala?Leu?Arg?Asn?Leu?Lys?Leu?Asp

150 155 160 165

ccc?ggt?gcg?gct?gtc?gcg?gtc?ttt?gga?atc?ggc?ggt?tta?gtg?cgc?cta 643

Pro?Gly?Ala?Ala?Val?Ala?Val?Phe?Gly?Ile?Gly?Gly?Leu?Val?Arg?Leu

170 175 180

gct?att?cag?ttt?gct?gcg?aaa?atg?ggt?tat?cga?acc?atc?acc?atc?gcc 691

Ala?Ile?Gln?Phe?Ala?Ala?Lys?Met?Gly?Tyr?Arg?Thr?Ile?Thr?Ile?Ala

185 190 195

cgc?ggt?tta?gag?cgt?gag?gag?cta?gct?agg?caa?ctt?ggc?gcc?aac?cac 739

Arg?Gly?Leu?Glu?Arg?Glu?Glu?Leu?Ala?Arg?Gln?Leu?Gly?Ala?Asn?His

200 205 210

tac?atc?gat?agc?aat?gat?ctg?cac?cct?ggc?cag?gcg?tta?ttt?gaa?ctt 787

Tyr?Ile?Asp?Ser?Asn?Asp?Leu?His?Pro?Gly?Gln?Ala?Leu?Phe?Glu?Leu

215 220 225

ggc?ggg?gct?gac?ttg?atc?ttg?tct?act?gcg?tcc?acc?acg?gag?cct?ctt 835

Gly?Gly?Ala?Asp?Leu?Ile?Leu?Ser?Thr?Ala?Ser?Thr?Thr?Glu?Pro?Leu

230 235 240 245

tcg?gag?ttg?tct?acc?ggt?ctt?tct?att?ggc?ggg?cag?cta?acc?att?atc 883

Ser?Glu?Leu?Ser?Thr?Gly?Leu?Ser?Ile?Gly?Gly?Gln?Leu?Thr?Ile?Ile

250 255 260

gga?gtt?gat?ggg?gga?gat?atc?acc?gtt?tcg?gca?gcc?caa?ttg?atg?atg 931

Gly?Val?Asp?Gly?Gly?Asp?Ile?Thr?Val?Ser?Ala?Ala?Gln?Leu?Met?Met

265 270 275

aac?cgt?cag?atc?atc?aca?ggt?cac?ctc?act?gga?agt?gcg?aat?gac?acg 979

Asn?Arg?Gln?Ile?Ile?Thr?Gly?His?Leu?Thr?Gly?Ser?Ala?Asn?Asp?Thr

280 285 290

gaa?cag?act?atg?aaa?ttt?gct?cat?ctc?cat?ggc?gtg?aaa?ccg?ctt?att 1027

Glu?Gln?Thr?Met?Lys?Phe?Ala?His?Leu?His?Gly?Val?Lys?Pro?Leu?Ile

295 300 305

gaa?cgg?atg?cct?ctc?gat?caa?gcc?aac?gag?gct?att?gca?cgt?att?tca 1075

Glu?Arg?Met?Pro?Leu?Asp?Gln?Ala?Asn?Glu?Ala?Ile?Ala?Arg?Ile?Ser

310 315 320 325

gct?ggt?aaa?cca?cgt?ttc?cgt?att?gtc?ttg?gag?ccg?aat?tca 1117

Ala?Gly?Lys?Pro?Arg?Phe?Arg?Ile?Val?Leu?Glu?Pro?Asn?Ser

330 335

taatgccaac?agcaagccca?att 1140

<210>242

<211>339

<212>PRT

＜213〉Corynebacterium glutamicum

<400>242

Met?Pro?Lys?Tyr?Ile?Ala?Met?Gln?Val?Ser?Glu?Ser?Gly?Ala?Pro?Leu

1 5 10 15

Ala?Ala?Asn?Leu?Val?Gln?Pro?Ala?Pro?Leu?Lys?Ser?Arg?Glu?Val?Arg

20 25 30

Val?Glu?Ile?Ala?Ala?Ser?Gly?Val?Cys?His?Ala?Asp?Ile?Gly?Thr?Ala

35 40 45

Ala?Ala?Ser?Gly?Lys?His?Thr?Val?Phe?Pro?Val?Thr?Pro?Gly?His?Glu

50 55 60

Ile?Ala?Gly?Thr?Ile?Ala?Glu?Ile?Gly?Glu?Asn?Val?Ser?Arg?Trp?Thr

65 70 75 80

Val?Gly?Asp?Arg?Val?Ala?Ile?Gly?Trp?Phe?Gly?Gly?Asn?Cys?Gly?Asp

85 90 95

Cys?Ala?Phe?Cys?Arg?Ala?Gly?Asp?Pro?Val?His?Cys?Arg?Glu?Arg?Lys

100 105 110

Ile?Pro?Gly?Val?Ser?Tyr?Ala?Gly?Gly?Trp?Ala?Gln?Asn?Ile?Val?Val

115 120 125

Pro?Ala?Glu?Ala?Leu?Ala?Ala?Ile?Pro?Asp?Gly?Met?Asp?Phe?Tyr?Glu

130 135 140

Pro?Ala?Pro?Met?Gly?Cys?Ala?Gly?Val?Thr?Thr?Phe?Asn?Ala?Leu?Arg

145 150 155 160

Asn?Leu?Lys?Leu?Asp?Pro?Gly?Ala?Ala?Val?Ala?Val?Phe?Gly?Ile?Gly

165 170 175

Gly?Leu?Val?Arg?Leu?Ala?Ile?Gln?Phe?Ala?Ala?Lys?Met?Gly?Tyr?Arg

180 185 190

Thr?Ile?Thr?Ile?Ala?Arg?Gly?Leu?Glu?Arg?Glu?Glu?Leu?Ala?Arg?Gln

195 200 205

Leu?Gly?Ala?Asn?His?Tyr?Ile?Asp?Ser?Asn?Asp?Leu?His?Pro?Gly?Gln

210 215 220

Ala?Leu?Phe?Glu?Leu?Gly?Gly?Ala?Asp?Leu?Ile?Leu?Ser?Thr?Ala?Ser

225 230 235 240

Thr?Thr?Glu?Pro?Leu?Ser?Glu?Leu?Ser?Thr?Gly?Leu?Ser?Ile?Gly?Gly

245 250 255

Gln?Leu?Thr?Ile?Ile?Gly?Val?Asp?Gly?Gly?Asp?Ile?Thr?Val?Ser?Ala

260 265 270

Ala?Gln?Leu?Met?Met?Asn?Arg?Gln?Ile?Ile?Thr?Gly?His?Leu?Thr?Gly

275 280 285

Ser?Ala?Asn?Asp?Thr?Glu?Gln?Thr?Met?Lys?Phe?Ala?His?Leu?His?Gly

290 295 300

Val?Lys?Pro?Leu?Ile?Glu?Arg?Met?Pro?Leu?Asp?Gln?Ala?Asn?Glu?Ala

305 310 315 320

Ile?Ala?Arg?Ile?Ser?Ala?Gly?Lys?Pro?Arg?Phe?Arg?Ile?Val?Leu?Glu

325 330 335

Pro?Asn?Ser

<210>243

<211>1665

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1642)

<223>RXA02737

<400>243

agcacgctgc?atcagtaacg?gcgacatgaa?atcgaattag?ttcgatctta?tgtggccgtt?60

acacatcttt?cattaaagaa?aggatcgtga?cactaccatc?gtg?agc?aca?aac?acg 115

Val?Ser?Thr?Asn?Thr

1 5

acc?ccc?tcc?agc?tgg?aca?aac?cca?ctg?cgc?gac?ccg?cag?gat?aaa?cga 163

Thr?Pro?Ser?Ser?Trp?Thr?Asn?Pro?Leu?Arg?Asp?Pro?Gln?Asp?Lys?Arg

10 15 20

ctc?ccc?cgc?atc?gct?ggc?cct?tcc?ggc?atg?gtg?atc?ttc?ggt?gtc?act 211

Leu?Pro?Arg?Ile?Ala?Gly?Pro?Ser?Gly?Met?Val?Ile?Phe?Gly?Val?Thr

25 30 35

ggc?gac?ttg?gct?cga?aag?aag?ctg?ctc?ccc?gcc?att?tat?gat?cta?gca 259

Gly?Asp?Leu?Ala?Arg?Lys?Lys?Leu?Leu?Pro?Ala?Ile?Tyr?Asp?Leu?Ala

40 45 50

aac?cgc?gga?ttg?ctg?ccc?cca?gga?ttc?tcg?ttg?gta?ggt?tac?ggc?cgc 307

Asn?Arg?Gly?Leu?Leu?Pro?Pro?Gly?Phe?Ser?Leu?Val?Gly?Tyr?Gly?Arg

55 60 65

cgc?gaa?tgg?tcc?aaa?gaa?gac?ttt?gaa?aaa?tac?gta?cgc?gat?gcc?gca 355

Arg?Glu?Trp?Ser?Lys?Glu?Asp?Phe?Glu?Lys?Tyr?Val?Arg?Asp?Ala?Ala

70 75 80 85

agt?gct?ggt?gct?cgt?acg?gaa?ttc?cgt?gaa?aat?gtt?tgg?gag?cgc?ctc 403

Ser?Ala?Gly?Ala?Arg?Thr?Glu?Phe?Arg?Glu?Asn?Val?Trp?Glu?Arg?Leu

90 95 100

gcc?gag?ggt?atg?gaa?ttt?gtt?cgc?ggc?aac?ttt?gat?gat?gat?gca?gct 451

Ala?Glu?Gly?Met?Glu?Phe?Val?Arg?Gly?Asn?Phe?Asp?Asp?Asp?Ala?Ala

105 110 115

ttc?gac?aac?ctc?gct?gca?aca?ctc?aag?cgc?atc?gac?aaa?acc?cgc?ggc 499

Phe?Asp?Asn?Leu?Ala?Ala?Thr?Leu?Lys?Arg?Ile?Asp?Lys?Thr?Arg?Gly

120 125 130

acc?gcc?ggc?aac?tgg?gct?tac?tac?ctg?tcc?att?cca?cca?gat?tcc?ttc 547

Thr?Ala?Gly?Asn?Trp?Ala?Tyr?Tyr?Leu?Ser?Ile?Pro?Pro?Asp?Ser?Phe

135 140 145

aca?gcg?gtc?tgc?cac?cag?ctg?gag?cgt?tcc?ggc?atg?gct?gaa?tcc?acc 595

Thr?Ala?Val?Cys?His?Gln?Leu?Glu?Arg?Ser?Gly?Met?Ala?Glu?Ser?Thr

150 155 160 165

gaa?gaa?gca?tgg?cgc?cgc?gtg?atc?atc?gag?aag?cct?ttc?ggc?cac?aac 643

Glu?Glu?Ala?Trp?Arg?Arg?Val?Ile?Ile?Glu?Lys?Pro?Phe?Gly?His?Asn

170 175 180

ctc?gaa?tcc?gca?cac?gag?ctc?aac?cag?ctg?gtc?aac?gca?gtc?ttc?cca 691

Leu?Glu?Ser?Ala?His?Glu?Leu?Asn?Gln?Leu?Val?Asn?Ala?Val?Phe?Pro

185 190 195

gaa?tct?tct?gtg?ttc?cgc?atc?gac?cac?tat?ttg?ggc?aag?gaa?aca?gtt 739

Glu?Ser?Ser?Val?Phe?Arg?Ile?Asp?His?Tyr?Leu?Gly?Lys?Glu?Thr?Val

200 205 210

caa?aac?atc?ctg?gct?ctg?cgt?ttt?gct?aac?cag?ctg?ttt?gag?cca?ctg 787

Gln?Asn?Ile?Leu?Ala?Leu?Arg?Phe?Ala?Asn?Gln?Leu?Phe?Glu?Pro?Leu

215 220 225

tgg?aac?tcc?aac?tac?gtt?gac?cac?gtc?cag?atc?acc?atg?gct?gaa?gat 835

Trp?Asn?Ser?Asn?Tyr?Val?Asp?His?Val?Gln?Ile?Thr?Met?Ala?Glu?Asp

230 235 240 245

att?ggc?ttg?ggt?gga?cgt?gct?ggt?tac?tac?gac?ggc?atc?ggc?gca?gcc 883

Ile?Gly?Leu?Gly?Gly?Arg?Ala?Gly?Tyr?Tyr?Asp?Gly?Ile?Gly?Ala?Ala

250 255 260

cgc?gac?gtc?atc?cag?aac?cac?ctg?atc?cag?ctc?ttg?gct?ctg?gtt?gcc 931

Arg?Asp?Val?Ile?Gln?Asn?His?Leu?Ile?Gln?Leu?Leu?Ala?Leu?Val?Ala

265 270 275

atg?gaa?gaa?cca?att?tct?ttc?gtg?cca?gcg?cag?ctg?cag?gca?gaa?aag 979

Met?Glu?Glu?Pro?Ile?Ser?Phe?Val?Pro?Ala?Gln?Leu?Gln?Ala?Glu?Lys

280 285 290

atc?aag?gtg?ctc?tct?gcg?aca?aag?ccg?tgc?tac?cca?ttg?gat?aaa?acc 1027

Ile?Lys?Val?Leu?Ser?Ala?Thr?Lys?Pro?Cys?Tyr?Pro?Leu?Asp?Lys?Thr

295 300 305

tcc?gct?cgt?ggt?cag?tac?gct?gcc?ggt?tgg?cag?ggc?tct?gag?tta?gtc 1075

Ser?Ala?Arg?Gly?Gln?Tyr?Ala?Ala?Gly?Trp?Gln?Gly?Ser?Glu?Leu?Val

310 315 320 325

aag?gga?ctt?cgc?gaa?gaa?gat?ggc?ttc?aac?cct?gag?tcc?acc?act?gag 1123

Lys?Gly?Leu?Arg?Glu?Glu?Asp?Gly?Phe?Asn?Pro?Glu?Ser?Thr?Thr?Glu

330 335 340

act?ttt?gcg?gct?tgt?acc?tta?gag?atc?acg?tct?cgt?cgc?tgg?gct?ggt 1171

Thr?Phe?Ala?Ala?Cys?Thr?Leu?Glu?Ile?Thr?Ser?Arg?Arg?Trp?Ala?Gly

345 350 355

gtg?ccg?ttc?tac?ctg?cgc?acc?ggt?aag?cgt?ctt?ggt?cgc?cgt?gtt?act 1219

Val?Pro?Phe?Tyr?Leu?Arg?Thr?Gly?Lys?Arg?Leu?Gly?Arg?Arg?Val?Thr

360 365 370

gag?att?gcc?gtg?gtg?ttt?aaa?gac?gca?cca?cac?cag?cct?ttc?gac?ggc 1267

Glu?Ile?Ala?Val?Val?Phe?Lys?Asp?Ala?Pro?His?Gln?Pro?Phe?Asp?Gly

375 380 385

gac?atg?act?gta?tcc?ctt?ggc?caa?aac?gcc?atc?gtg?att?cgc?gtg?cag 1315

Asp?Met?Thr?Val?Ser?Leu?Gly?Gln?Asn?Ala?Ile?Val?Ile?Arg?Val?Gln

390 395 400 405

cct?gat?gaa?ggt?gtg?ctc?atc?cgc?ttc?ggt?tcc?aag?gtt?cca?ggt?tct 1363

Pro?Asp?Glu?Gly?Val?Leu?Ile?Arg?Phe?Gly?Ser?Lys?Val?Pro?Gly?Ser

410 415 420

gcc?atg?gaa?gtc?cgt?gac?gtc?aac?atg?gac?ttc?tcc?tac?tca?gaa?tcc 1411

Ala?Met?Glu?Val?Arg?Asp?Val?Asn?Met?Asp?Phe?Ser?Tyr?Ser?Glu?Ser

425 430 435

ttc?act?gaa?gaa?tca?cct?gaa?gca?tac?gag?cgc?ctc?att?ttg?gat?gcg 1459

Phe?Thr?Glu?Glu?Ser?Pro?Glu?Ala?Tyr?Glu?Arg?Leu?Ile?Leu?Asp?Ala

440 445 450

ctg?tta?gat?gaa?tcc?agc?ctc?ttc?cct?acc?aac?gag?gaa?gtg?gaa?ctg 1507

Leu?Leu?Asp?Glu?Ser?Ser?Leu?Phe?Pro?Thr?Asn?Glu?Glu?Val?Glu?Leu

455 460 465

agc?tgg?aag?att?ctg?gat?cca?att?ctt?gaa?gca?tgg?gat?gcc?gat?gga 1555

Ser?Trp?Lys?Ile?Leu?Asp?Pro?Ile?Leu?Glu?Ala?Trp?Asp?Ala?Asp?Gly

470 475 480 485

gaa?cca?gag?gat?tac?cca?gcg?ggt?acg?tgg?ggt?cca?aag?agc?gct?gat 1603

Glu?Pro?Glu?Asp?Tyr?Pro?Ala?Gly?Thr?Trp?Gly?Pro?Lys?Ser?Ala?Asp

490 495 500

gaa?atg?ctt?tcc?cgc?aac?ggt?cac?acc?tgg?cgc?agg?cca?taatttaggg 1652

Glu?Met?Leu?Ser?Arg?Asn?Gly?His?Thr?Trp?Arg?Arg?Pro

505 510

gcaaaaaatg?atc 1665

<210>244

<211>514

<212>PRT

＜213〉Corynebacterium glutamicum

<400>244

Val?Ser?Thr?Asn?Thr?Thr?Pro?Ser?Ser?Trp?Thr?Asn?Pro?Leu?Arg?Asp

1 5 10 15

Pro?Gln?Asp?Lys?Arg?Leu?Pro?Arg?Ile?Ala?Gly?Pro?Ser?Gly?Met?Val

20 25 30

Ile?Phe?Gly?Val?Thr?Gly?Asp?Leu?Ala?Arg?Lys?Lys?Leu?Leu?Pro?Ala

35 40 45

Ile?Tyr?Asp?Leu?Ala?Asn?Arg?Gly?Leu?Leu?Pro?Pro?Gly?Phe?Ser?Leu

50 55 60

Val?Gly?Tyr?Gly?Arg?Arg?Glu?Trp?Ser?Lys?Glu?Asp?Phe?Glu?Lys?Tyr

65 70 75 80

Val?Arg?Asp?Ala?Ala?Ser?Ala?Gly?Ala?Arg?Thr?Glu?Phe?Arg?Glu?Asn

85 90 95

Val?Trp?Glu?Arg?Leu?Ala?Glu?Gly?Met?Glu?Phe?Val?Arg?Gly?Asn?Phe

100 105 110

Asp?Asp?Asp?Ala?Ala?Phe?Asp?Asn?Leu?Ala?Ala?Thr?Leu?Lys?Arg?Ile

115 120 125

Asp?Lys?Thr?Arg?Gly?Thr?Ala?Gly?Asn?Trp?Ala?Tyr?Tyr?Leu?Ser?Ile

130 135 140

Pro?Pro?Asp?Ser?Phe?Thr?Ala?Val?Cys?His?Gln?Leu?Glu?Arg?Ser?Gly

145 150 155 160

Met?Ala?Glu?Ser?Thr?Glu?Glu?Ala?Trp?Arg?Arg?Val?Ile?Ile?Glu?Lys

165 170 175

Pro?Phe?Gly?His?Asn?Leu?Glu?Ser?Ala?His?Glu?Leu?Asn?Gln?Leu?Val

180 185 190

Asn?Ala?Val?Phe?Pro?Glu?Ser?Ser?Val?Phe?Arg?Ile?Asp?His?Tyr?Leu

195 200 205

Gly?Lys?Glu?Thr?Val?Gln?Asn?Ile?Leu?Ala?Leu?Arg?Phe?Ala?Asn?Gln

210 215 220

Leu?Phe?Glu?Pro?Leu?Trp?Asn?Ser?Asn?Tyr?Val?Asp?His?Val?Gln?Ile

225 230 235 240

Thr?Met?Ala?Glu?Asp?Ile?Gly?Leu?Gly?Gly?Arg?Ala?Gly?Tyr?Tyr?Asp

245 250 255

Gly?Ile?Gly?Ala?Ala?Arg?Asp?Val?Ile?Gln?Asn?His?Leu?Ile?Gln?Leu

260 265 270

Leu?Ala?Leu?Val?Ala?Met?Glu?Glu?Pro?Ile?Ser?Phe?Val?Pro?Ala?Gln

275 280 285

Leu?Gln?Ala?Glu?Lys?Ile?Lys?Val?Leu?Ser?Ala?Thr?Lys?Pro?Cys?Tyr

290 295 300

Pro?Leu?Asp?Lys?Thr?Ser?Ala?Arg?Gly?Gln?Tyr?Ala?Ala?Gly?Trp?Gln

305 310 315 320

Gly?Ser?Glu?Leu?Val?Lys?Gly?Leu?Arg?Glu?Glu?Asp?Gly?Phe?Asn?Pro

325 330 335

Glu?Ser?Thr?Thr?Glu?Thr?Phe?Ala?Ala?Cys?Thr?Leu?Glu?Ile?Thr?Ser

340 345 350

Arg?Arg?Trp?Ala?Gly?Val?Pro?Phe?Tyr?Leu?Arg?Thr?Gly?Lys?Arg?Leu

355 360 365

Gly?Arg?Arg?Val?Thr?Glu?Ile?Ala?Val?Val?Phe?Lys?Asp?Ala?Pro?His

370 375 380

Gln?Pro?Phe?Asp?Gly?Asp?Met?Thr?Val?Ser?Leu?Gly?Gln?Asn?Ala?Ile

385 390 395 400

Val?Ile?Arg?Val?Gln?Pro?Asp?Glu?Gly?Val?Leu?Ile?Arg?Phe?Gly?Ser

405 410 415

Lys?Val?Pro?Gly?Ser?Ala?Met?Glu?Val?Arg?Asp?Val?Asn?Met?Asp?Phe

420 425 430

Ser?Tyr?Ser?Glu?Ser?Phe?Thr?Glu?Glu?Ser?Pro?Glu?Ala?Tyr?Glu?Arg

435 440 445

Leu?Ile?Leu?Asp?Ala?Leu?Leu?Asp?Glu?Ser?Ser?Leu?Phe?Pro?Thr?Asn

450 455 460

Glu?Glu?Val?Glu?Leu?Ser?Trp?Lys?Ile?Leu?Asp?Pro?Ile?Leu?Glu?Ala

465 470 475 480

Trp?Asp?Ala?Asp?Gly?Glu?Pro?Glu?Asp?Tyr?Pro?Ala?Gly?Thr?Trp?Gly

485 490 495

Pro?Lys?Ser?Ala?Asp?Glu?Met?Leu?Ser?Arg?Asn?Gly?His?Thr?Trp?Arg

500 505 510

Arg?Pro

<210>245

<211>1203

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1180)

<223>RXA02738

<400>245

ttgttgttaa?tcggtacaaa?gggtcttaag?cacatccctt?acttgcctgc?tctccttgag?60

cacagttcaa?gaacaattct?tttaaggaaa?atttagtttc?atg?tct?cac?att?gat 115

Met?Ser?His?Ile?Asp

1 5

gat?ctt?gca?cag?ctc?ggc?act?tcc?act?tgg?ctc?gac?gac?ctc?tcc?cgc 163

Asp?Leu?Ala?Gln?Leu?Gly?Thr?Ser?Thr?Trp?Leu?Asp?Asp?Leu?Ser?Arg

10 15 20

gag?cgc?att?act?tcc?ggc?aat?ctc?agc?cag?gtt?att?gag?gaa?aag?tct 211

Glu?Arg?Ile?Thr?Ser?Gly?Asn?Leu?Ser?Gln?Val?Ile?Glu?Glu?Lys?Ser

25 30 35

gta?gtc?ggt?gtc?acc?acc?aac?cca?gct?att?ttc?gca?gca?gca?atg?tcc 259

Val?Val?Gly?Val?Thr?Thr?Asn?Pro?Ala?Ile?Phe?Ala?Ala?Ala?Met?Ser

40 45 50

aag?ggc?gat?tcc?tac?gac?gct?cag?atc?gca?gag?ctc?aag?gcc?gct?ggc 307

Lys?Gly?Asp?Ser?Tyr?Asp?Ala?Gln?Ile?Ala?Glu?Leu?Lys?Ala?Ala?Gly

55 60 65

gca?tct?gtt?gac?cag?gct?gtt?tac?gcc?atg?agc?atc?gac?gac?gtt?cgc 355

Ala?Ser?Val?Asp?Gln?Ala?Val?Tyr?Ala?Met?Ser?Ile?Asp?Asp?Val?Arg

70 75 80 85

aat?gct?tgt?gat?ctg?ttc?acc?ggc?atc?ttc?gag?tcc?tcc?aac?ggc?tac 403

Asn?Ala?Cys?Asp?Leu?Phe?Thr?Gly?Ile?Phe?Glu?Ser?Ser?Asn?Gly?Tyr

90 95 100

gac?ggc?cgc?gtg?tcc?atc?gag?gtt?gac?cca?cgt?atc?tct?gct?gac?cgc 451

Asp?Gly?Arg?Val?Ser?Ile?Glu?Val?Asp?Pro?Arg?Ile?Ser?Ala?Asp?Arg

105 110 115

gac?gca?acc?ctg?gct?cag?gcc?aag?gag?ctg?tgg?gca?aag?gtt?gat?cgt 499

Asp?Ala?Thr?Leu?Ala?Gln?Ala?Lys?Glu?Leu?Trp?Ala?Lys?Val?Asp?Arg

120 125 130

cca?aac?gtc?atg?atc?aag?atc?cct?gca?acc?cca?ggt?tct?ttg?cca?gca 547

Pro?Asn?Val?Met?Ile?Lys?Ile?Pro?Ala?Thr?Pro?Gly?Ser?Leu?Pro?Ala

135 140 145

atc?acc?gac?gct?ttg?gct?gag?ggc?atc?agc?gtt?aac?gtc?acc?ttg?atc 595

Ile?Thr?Asp?Ala?Leu?Ala?Glu?Gly?Ile?Ser?Val?Asn?Val?Thr?Leu?Ile

150 155 160 165

ttc?tcc?gtt?gct?cgc?tac?cgc?gag?gtc?atc?gct?gcg?ttc?atc?gag?ggc 643

Phe?Ser?Val?Ala?Arg?Tyr?Arg?Glu?Val?Ile?Ala?Ala?Phe?Ile?Glu?Gly

170 175 180

atc?aag?cag?gct?gct?gca?aac?ggc?cac?gac?gtc?tcc?aag?atc?cac?tct 691

Ile?Lys?Gln?Ala?Ala?Ala?Asn?Gly?His?Asp?Val?Ser?Lys?Ile?His?Ser

185 190 195

gtg?gct?tcc?ttc?ttc?gtc?tcc?cgc?gtc?gac?gtt?gag?atc?gac?aag?cgc 739

Val?Ala?Ser?Phe?Phe?Val?Ser?Arg?Val?Asp?Val?Glu?Ile?Asp?Lys?Arg

200 205 210

ctc?gag?gca?atc?gga?tcc?gat?gag?gct?ttg?gct?ctg?cgc?ggc?aag?gca 787

Leu?Glu?Ala?Ile?Gly?Ser?Asp?Glu?Ala?Leu?Ala?Leu?Arg?Gly?Lys?Ala

215 220 225

ggc?gtt?gcc?aac?gct?cag?cgc?gct?tac?gct?gtg?tac?aag?gag?ctt?ttc 835

Gly?Val?Ala?Asn?Ala?Gln?Arg?Ala?Tyr?Ala?Val?Tyr?Lys?Glu?Leu?Phe

230 235 240 245

gac?gcc?gcc?gag?ctg?cct?gaa?ggt?gcc?aac?act?cag?cgc?cca?ctg?tgg 883

Asp?Ala?Ala?Glu?Leu?Pro?Glu?Gly?Ala?Asn?Thr?Gln?Arg?Pro?Leu?Trp

250 255 260

gca?tcc?acc?ggc?gtg?aag?aac?cct?gcg?tac?gct?gca?act?ctt?tac?gtt 931

Ala?Ser?Thr?Gly?Val?Lys?Asn?Pro?Ala?Tyr?Ala?Ala?Thr?Leu?Tyr?Val

265 270 275

tcc?gag?ctg?gct?ggt?cca?aac?acc?gtc?aac?acc?atg?cca?gaa?ggc?acc 979

Ser?Glu?Leu?Ala?Gly?Pro?Asn?Thr?Val?Asn?Thr?Met?Pro?Glu?Gly?Thr

280 285 290

atc?gac?gcg?gtt?ctg?gag?cag?ggc?aac?ctg?cac?ggt?gac?acc?ctg?tcc 1027

Ile?Asp?Ala?Val?Leu?Glu?Gln?Gly?Asn?Leu?His?Gly?Asp?Thr?Leu?Ser

295 300 305

aac?tcc?gcg?gca?gaa?gct?gac?gct?gtg?ttc?tcc?cag?ctt?gag?gct?ctg 1075

Asn?Ser?Ala?Ala?Glu?Ala?Asp?Ala?Val?Phe?Ser?Gln?Leu?Glu?Ala?Leu

310 315 320 325

ggc?gtt?gac?ttg?gca?gat?gtc?ttc?cag?gtc?ctg?gag?acc?gag?ggt?gtg 1123

Gly?Val?Asp?Leu?Ala?Asp?Val?Phe?Gln?Val?Leu?Glu?Thr?Glu?Gly?Val

330 335 340

gac?aag?ttc?gtt?gct?tct?tgg?agc?gaa?ctg?ctt?gag?tcc?atg?gaa?gct 1171

Asp?Lys?Phe?Val?Ala?Ser?Trp?Ser?Glu?Leu?Leu?Glu?Ser?Met?Glu?Ala

345 350 355

cgc?ctg?aag?tagaatcagc?acgctgcatc?agt 1203

Arg?Leu?Lys

360

<210>246

<211>360

<212>PRT

＜213〉Corynebacterium glutamicum

<400>246

Met?Ser?His?Ile?Asp?Asp?Leu?Ala?Gln?Leu?Gly?Thr?Ser?Thr?Trp?Leu

1 5 10 15

Asp?Asp?Leu?Ser?Arg?Glu?Arg?Ile?Thr?Ser?Gly?Asn?Leu?Ser?Gln?Val

20 25 30

Ile?Glu?Glu?Lys?Ser?Val?Val?Gly?Val?Thr?Thr?Asn?Pro?Ala?Ile?Phe

35 40 45

Ala?Ala?Ala?Met?Ser?Lys?Gly?Asp?Ser?Tyr?Asp?Ala?Gln?Ile?Ala?Glu

50 55 60

Leu?Lys?Ala?Ala?Gly?Ala?Ser?Val?Asp?Gln?Ala?Val?Tyr?Ala?Met?Ser

65 70 75 80

Ile?Asp?Asp?Val?Arg?Asn?Ala?Cys?Asp?Leu?Phe?Thr?Gly?Ile?Phe?Glu

85 90 95

Ser?Ser?Asn?Gly?Tyr?Asp?Gly?Arg?Val?Ser?Ile?Glu?Val?Asp?Pro?Arg

100 105 110

Ile?Ser?Ala?Asp?Arg?Asp?Ala?Thr?Leu?Ala?Gln?Ala?Lys?Glu?Leu?Trp

115 120 125

Ala?Lys?Val?Asp?Arg?Pro?Asn?Val?Met?Ile?Lys?Ile?Pro?Ala?Thr?Pro

130 135 140

Gly?Ser?Leu?Pro?Ala?Ile?Thr?Asp?Ala?Leu?Ala?Glu?Gly?Ile?Ser?Val

145 150 155 160

Asn?Val?Thr?Leu?Ile?Phe?Ser?Val?Ala?Arg?Tyr?Arg?Glu?Val?Ile?Ala

165 170 175

Ala?Phe?Ile?Glu?Gly?Ile?Lys?Gln?Ala?Ala?Ala?Asn?Gly?His?Asp?Val

180 185 190

Ser?Lys?Ile?His?Ser?Val?Ala?Ser?Phe?Phe?Val?Ser?Arg?Val?Asp?Val

195 200 205

Glu?Ile?Asp?Lys?Arg?Leu?Glu?Ala?Ile?Gly?Ser?Asp?Glu?Ala?Leu?Ala

210 215 220

Leu?Arg?Gly?Lys?Ala?Gly?Val?Ala?Asn?Ala?Gln?Arg?Ala?Tyr?Ala?Val

225 230 235 240

Tyr?Lys?Glu?Leu?Phe?Asp?Ala?Ala?Glu?Leu?Pro?Glu?Gly?Ala?Asn?Thr

245 250 255

Gln?Arg?Pro?Leu?Trp?Ala?Ser?Thr?Gly?Val?Lys?Asn?Pro?Ala?Tyr?Ala

260 265 270

Ala?Thr?Leu?Tyr?Val?Ser?Glu?Leu?Ala?Gly?Pro?Asn?Thr?Val?Asn?Thr

275 280 285

Met?Pro?Glu?Gly?Thr?Ile?Asp?Ala?Val?Leu?Glu?Gln?Gly?Asn?Leu?His

290 295 300

Gly?Asp?Thr?Leu?Ser?Asn?Ser?Ala?Ala?Glu?Ala?Asp?Ala?Val?Phe?Ser

305 310 315 320

Gln?Leu?Glu?Ala?Leu?Gly?Val?Asp?Leu?Ala?Asp?Val?Phe?Gln?Val?Leu

325 330 335

Glu?Thr?Glu?Gly?Val?Asp?Lys?Phe?Val?Ala?Ser?Trp?Ser?Glu?Leu?Leu

340 345 350

Glu?Ser?Met?Glu?Ala?Arg?Leu?Lys

355 360

<210>247

<211>2223

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(2200)

<223>RXA02739

<400>247

cctttgccaa?atttgaacca?attaacctaa?gtcgtagatc?tgatcatcgg?atctaacgaa?60

aacgaaccaa?aactttggtc?ccggtttaac?ccaggaagga?ttg?acc?acc?ttg?acg 115

Leu?Thr?Thr?Leu?Thr

1 5

ctg?tca?cct?gaa?ctt?cag?gcg?ctc?act?gta?cgc?aat?tac?ccc?tct?gat 163

Leu?Ser?Pro?Glu?Leu?Gln?Ala?Leu?Thr?Val?Arg?Asn?Tyr?Pro?Ser?Asp

10 15 20

tgg?tcc?gat?gtg?gac?acc?aag?gct?gta?gac?act?gtt?cgt?gtc?ctc?gct 211

Trp?Ser?Asp?Val?Asp?Thr?Lys?Ala?Val?Asp?Thr?Val?Arg?Val?Leu?Ala

25 30 35

gca?gac?gct?gta?gaa?aac?tgt?ggc?tcc?ggc?cac?cca?ggc?acc?gca?atg 259

Ala?Asp?Ala?Val?Glu?Asn?Cys?Gly?Ser?Gly?His?Pro?Gly?Thr?Ala?Met

40 45 50

agc?ctg?gct?ccc?ctt?gca?tac?acc?ttg?tac?cag?cgg?gtt?atg?aac?gta 307

Ser?Leu?Ala?Pro?Leu?Ala?Tyr?Thr?Leu?Tyr?Gln?Arg?Val?Met?Asn?Val

55 60 65

gat?cca?cag?gac?acc?aac?tgg?gca?ggc?cgt?gac?cgc?ttc?gtt?ctt?tct 355

Asp?Pro?Gln?Asp?Thr?Asn?Trp?Ala?Gly?Arg?Asp?Arg?Phe?Val?Leu?Ser

70 75 80 85

tgt?ggc?cac?tcc?tct?ttg?acc?cag?tac?atc?cag?ctt?tac?ttg?ggt?gga 403

Cys?Gly?His?Ser?Ser?Leu?Thr?Gln?Tyr?Ile?Gln?Leu?Tyr?Leu?Gly?Gly

90 95 100

ttc?ggc?ctt?gag?atg?gat?gac?ctg?aag?gct?ctg?cgc?acc?tgg?gat?tcc 451

Phe?Gly?Leu?Glu?Met?Asp?Asp?Leu?Lys?Ala?Leu?Arg?Thr?Trp?Asp?Ser

105 110 115

ttg?acc?cca?gga?cac?cct?gag?tac?cgc?cac?acc?aag?ggc?gtt?gag?atc 499

Leu?Thr?Pro?Gly?His?Pro?Glu?Tyr?Arg?His?Thr?Lys?Gly?Val?Glu?Ile

120 125 130

acc?act?ggc?cct?ctt?ggc?cag?ggt?ctt?gca?tct?gca?gtt?ggt?atg?gcc 547

Thr?Thr?Gly?Pro?Leu?Gly?Gln?Gly?Leu?Ala?Ser?Ala?Val?Gly?Met?Ala

135 140 145

atg?gct?gct?cgt?cgt?gag?cgt?ggc?cta?ttc?gac?cca?acc?gct?gct?gag 595

Met?Ala?Ala?Arg?Arg?Glu?Arg?Gly?Leu?Phe?Asp?Pro?Thr?Ala?Ala?Glu

150 155 160 165

ggc?gaa?tcc?cca?ttc?gac?cac?cac?atc?tac?gtc?att?gct?tct?gat?ggt 643

Gly?Glu?Ser?Pro?Phe?Asp?His?His?Ile?Tyr?Val?Ile?Ala?Ser?Asp?Gly

170 175 180

gac?ctg?cag?gaa?ggt?gtc?acc?tct?gag?gca?tcc?tcc?atc?gct?ggc?acc 691

Asp?Leu?Gln?Glu?Gly?Val?Thr?Ser?Glu?Ala?Ser?Ser?Ile?Ala?Gly?Thr

185 190 195

cag?cag?ctg?ggc?aac?ctc?atc?gtg?ttc?tgg?gat?gac?aac?cgc?atc?tcc 739

Gln?Gln?Leu?Gly?Asn?Leu?Ile?Val?Phe?Trp?Asp?Asp?Asn?Arg?Ile?Ser

200 205 210

atc?gaa?gac?aac?act?gag?atc?gct?ttc?aac?gag?gac?gtt?gtt?gct?cgt 787

Ile?Glu?Asp?Asn?Thr?Glu?Ile?Ala?Phe?Asn?Glu?Asp?Val?Val?Ala?Arg

215 220 225

tac?aag?gct?tac?ggc?tgg?cag?acc?att?gag?gtt?gag?gct?ggc?gag?gac 835

Tyr?Lys?Ala?Tyr?Gly?Trp?Gln?Thr?Ile?Glu?Val?Glu?Ala?Gly?Glu?Asp

230 235 240 245

gtt?gca?gca?atc?gaa?gct?gca?gtg?gct?gag?gct?aag?aag?gac?acc?aag 883

Val?Ala?Ala?Ile?Glu?Ala?Ala?Val?Ala?Glu?Ala?Lys?Lys?Asp?Thr?Lys

250 255 260

cga?cct?acc?ttc?atc?cgc?gtt?cgc?acc?atc?atc?ggc?ttc?cca?gct?cca 931

Arg?Pro?Thr?Phe?Ile?Arg?Val?Arg?Thr?Ile?Ile?Gly?Phe?Pro?Ala?Pro

265 270 275

act?atg?atg?aac?acc?ggt?gct?gtg?cac?ggt?gct?gct?ctt?ggc?gca?gct 979

Thr?Met?Met?Asn?Thr?Gly?Ala?Val?His?Gly?Ala?Ala?Leu?Gly?Ala?Ala

280 285 290

gag?gtt?gca?gca?acc?aag?act?gag?ctt?gga?ttc?gat?cct?gag?gct?cac 1027

Glu?Val?Ala?Ala?Thr?Lys?Thr?Glu?Leu?Gly?Phe?Asp?Pro?Glu?Ala?His

295 300 305

ttc?gcg?atc?gac?gat?gag?gtt?atc?gct?cac?acc?cgc?tcc?ctc?gca?gag 1075

Phe?Ala?Ile?Asp?Asp?Glu?Val?Ile?Ala?His?Thr?Arg?Ser?Leu?Ala?Glu

310 315 320 325

cgc?gct?gca?cag?aag?aag?gct?gca?tgg?cag?gtc?aag?ttc?gat?gag?tgg 1123

Arg?Ala?Ala?Gln?Lys?Lys?Ala?Ala?Trp?Gln?Val?Lys?Phe?Asp?Glu?Trp

330 335 340

gca?gct?gcc?aac?cct?gag?aac?aag?gct?ctg?ttc?gat?cgc?ctg?aac?tcc 1171

Ala?Ala?Ala?Asn?Pro?Glu?Asn?Lys?Ala?Leu?Phe?Asp?Arg?Leu?Asn?Ser

345 350 355

cgt?gag?ctt?cca?gcg?ggc?tac?gct?gac?gag?ctc?cca?aca?tgg?gat?gca 1219

Arg?Glu?Leu?Pro?Ala?Gly?Tyr?Ala?Asp?Glu?Leu?Pro?Thr?Trp?Asp?Ala

360 365 370

gat?gag?aag?ggc?gtc?gca?act?cgt?aag?gct?tcc?gag?gct?gca?ctt?cag 1267

Asp?Glu?Lys?Gly?Val?Ala?Thr?Arg?Lys?Ala?Ser?Glu?Ala?Ala?Leu?Gln

375 380 385

gca?ctg?ggc?aag?acc?ctt?cct?gag?ctg?tgg?ggc?ggt?tcc?gct?gac?ctc 1315

Ala?Leu?Gly?Lys?Thr?Leu?Pro?Glu?Leu?Trp?Gly?Gly?Ser?Ala?Asp?Leu

390 395 400 405

gca?ggt?tcc?aac?aac?acc?gtg?atc?aag?ggc?tcc?cct?tcc?ttc?ggc?cct 1363

Ala?Gly?Ser?Asn?Asn?Thr?Val?Ile?Lys?Gly?Ser?Pro?Ser?Phe?Gly?Pro

410 415 420

gag?tcc?atc?tcc?acc?gag?acc?tgg?tct?gct?gag?cct?tac?ggc?cgt?aac 1411

Glu?Ser?Ile?Ser?Thr?Glu?Thr?Trp?Ser?Ala?Glu?Pro?Tyr?Gly?Arg?Asn

425 430 435

ctg?cac?ttc?ggt?atc?cgt?gag?cac?gct?atg?gga?tcc?atc?ctc?aac?ggc 1459

Leu?His?Phe?Gly?Ile?Arg?Glu?His?Ala?Met?Gly?Ser?Ile?Leu?Asn?Gly

440 445 450

att?tcc?ctc?cac?ggt?ggc?acc?cgc?cca?tac?ggc?gga?acc?ttc?ctc?atc 1507

Ile?Ser?Leu?His?Gly?Gly?Thr?Arg?Pro?Tyr?Gly?Gly?Thr?Phe?Leu?Ile

455 460 465

ttc?tcc?gac?tac?atg?cgt?cct?gca?gtt?cgt?ctt?gca?gct?ctc?atg?gag 1555

Phe?Ser?Asp?Tyr?Met?Arg?Pro?Ala?Val?Arg?Leu?Ala?Ala?Leu?Met?Glu

470 475 480 485

acc?gac?gct?tac?tac?gtc?tgg?acc?cac?gac?tcc?atc?ggt?ctg?ggc?gaa 1603

Thr?Asp?Ala?Tyr?Tyr?Val?Trp?Thr?His?Asp?Ser?Ile?Gly?Leu?Gly?Glu

490 495 500

gat?ggc?cca?acc?cac?cag?cct?gtt?gaa?acc?ttg?gct?gca?ctg?cgc?gcc 1651

Asp?Gly?Pro?Thr?His?Gln?Pro?Val?Glu?Thr?Leu?Ala?Ala?Leu?Arg?Ala

505 510 515

atc?cca?ggt?ctg?tcc?gtc?ctg?cgt?cct?gca?gat?gcg?aac?gag?acc?gcc 1699

Ile?Pro?Gly?Leu?Ser?Val?Leu?Arg?Pro?Ala?Asp?Ala?Asn?Glu?Thr?Ala

520 525 530

cag?gct?tgg?gct?gca?gca?ctt?gag?tac?aag?gaa?ggc?cct?aag?ggt?ctt 1747

Gln?Ala?Trp?Ala?Ala?Ala?Leu?Glu?Tyr?Lys?Glu?Gly?Pro?Lys?Gly?Leu

535 540 545

gca?ctg?acc?cgc?cag?aac?gtt?cct?gtt?ctg?gaa?ggc?acc?aag?gag?aag 1795

Ala?Leu?Thr?Arg?Gln?Asn?Val?Pro?Val?Leu?Glu?Gly?Thr?Lys?Glu?Lys

550 555 560 565

gct?gct?gaa?ggc?gtt?cgc?cgc?ggt?ggc?tac?gtc?ctg?gtt?gag?ggt?tcc 1843

Ala?Ala?Glu?Gly?Val?Arg?Arg?Gly?Gly?Tyr?Val?Leu?Val?Glu?Gly?Ser

570 575 580

aag?gaa?acc?cca?gat?gtg?atc?ctc?atg?ggc?tcc?ggc?tcc?gag?gtt?cag 1891

Lys?Glu?Thr?Pro?Asp?Val?Ile?Leu?Met?Gly?Ser?Gly?Ser?Glu?Val?Gln

585 590 595

ctt?gca?gtt?aac?gct?gcg?aag?gct?ctg?gaa?gct?gag?ggc?gtt?gca?gct 1939

Leu?Ala?Val?Asn?Ala?Ala?Lys?Ala?Leu?Glu?Ala?Glu?Gly?Val?Ala?Ala

600 605 610

cgc?gtt?gtt?tcc?gtt?cct?tgc?atg?gat?tgg?ttc?cag?gag?cag?gac?gca 1987

Arg?Val?Val?Ser?Val?Pro?Cys?Met?Asp?Trp?Phe?Gln?Glu?Gln?Asp?Ala

615 620 625

gag?tac?atc?gag?tcc?gtt?ctg?cct?gca?gct?gtg?acc?gct?cgt?gtg?tct 2035

Glu?Tyr?Ile?Glu?Ser?Val?Leu?Pro?Ala?Ala?Val?Thr?Ala?Arg?Val?Ser

630 635 640 645

gtt?gaa?gct?ggc?atc?gca?atg?cct?tgg?tac?cgc?ttc?ttg?ggc?acc?cag 2083

Val?Glu?Ala?Gly?Ile?Ala?Met?Pro?Trp?Tyr?Arg?Phe?Leu?Gly?Thr?Gln

650 655 660

ggc?cgt?gct?gtc?tcc?ctt?gag?cac?ttc?ggt?gct?tct?gcg?gat?tac?cag 2131

Gly?Arg?Ala?Val?Ser?Leu?Glu?His?Phe?Gly?Ala?Ser?Ala?Asp?Tyr?Gln

665 670 675

acc?ctg?ttt?gag?aag?ttc?ggc?atc?acc?acc?gat?gca?gtc?gtg?gca?gcg 2179

Thr?Leu?Phe?Glu?Lys?Phe?Gly?Ile?Thr?Thr?Asp?Ala?Val?Val?Ala?Ala

680 685 690

gcc?aag?gac?tcc?att?aac?ggt?taattgccct?gctgttttta?gct 2223

Ala?Lys?Asp?Ser?Ile?Asn?Gly

695 700

<210>248

<211>700

<212>PRT

＜213〉Corynebacterium glutamicum

<400>248

Leu?Thr?Thr?Leu?Thr?Leu?Ser?Pro?Glu?Leu?Gln?Ala?Leu?Thr?Val?Arg

1 5 10 15

Asn?Tyr?Pro?Ser?Asp?Trp?Ser?Asp?Val?Asp?Thr?Lys?Ala?Val?Asp?Thr

20 25 30

Val?Arg?Val?Leu?Ala?Ala?Asp?Ala?Val?Glu?Asn?Cys?Gly?Ser?Gly?His

35 40 45

Pro?Gly?Thr?Ala?Met?Ser?Leu?Ala?Pro?Leu?Ala?Tyr?Thr?Leu?Tyr?Gln

50 55 60

Arg?Val?Met?Asn?Val?Asp?Pro?Gln?Asp?Thr?Asn?Trp?Ala?Gly?Arg?Asp

65 70 75 80

Arg?Phe?Val?Leu?Ser?Cys?Gly?His?Ser?Ser?Leu?Thr?Gln?Tyr?Ile?Gln

85 90 95

Leu?Tyr?Leu?Gly?Gly?Phe?Gly?Leu?Glu?Met?Asp?Asp?Leu?Lys?Ala?Leu

100 105 110

Arg?Thr?Trp?Asp?Ser?Leu?Thr?Pro?Gly?His?Pro?Glu?Tyr?Arg?His?Thr

115 120 125

Lys?Gly?Val?Glu?Ile?Thr?Thr?Gly?Pro?Leu?Gly?Gln?Gly?Leu?Ala?Ser

130 135 140

Ala?Val?Gly?Met?Ala?Met?Ala?Ala?Arg?Arg?Glu?Arg?Gly?Leu?Phe?Asp

145 150 155 160

Pro?Thr?Ala?Ala?Glu?Gly?Glu?Ser?Pro?Phe?Asp?His?His?Ile?Tyr?Val

165 170 175

Ile?Ala?Ser?Asp?Gly?Asp?Leu?Gln?Glu?Gly?Val?Thr?Ser?Glu?Ala?Ser

180 185 190

Ser?Ile?Ala?Gly?Thr?Gln?Gln?Leu?Gly?Asn?Leu?Ile?Val?Phe?Trp?Asp

195 200 205

Asp?Asn?Arg?Ile?Ser?Ile?Glu?Asp?Asn?Thr?Glu?Ile?Ala?Phe?Asn?Glu

210 215 220

Asp?Val?Val?Ala?Arg?Tyr?Lys?Ala?Tyr?Gly?Trp?Gln?Thr?Ile?Glu?Val

225 230 235 240

Glu?Ala?Gly?Glu?Asp?Val?Ala?Ala?Ile?Glu?Ala?Ala?Val?Ala?Glu?Ala

245 250 255

Lys?Lys?Asp?Thr?Lys?Arg?Pro?Thr?Phe?Ile?Arg?Val?Arg?Thr?Ile?Ile

260 265 270

Gly?Phe?Pro?Ala?Pro?Thr?Met?Met?Asn?Thr?Gly?Ala?Val?His?Gly?Ala

275 280 285

Ala?Leu?Gly?Ala?Ala?Glu?Val?Ala?Ala?Thr?Lys?Thr?Glu?Leu?Gly?Phe

290 295 300

Asp?Pro?Glu?Ala?His?Phe?Ala?Ile?Asp?Asp?Glu?Val?Ile?Ala?His?Thr

305 310 315 320

Arg?Ser?Leu?Ala?Glu?Arg?Ala?Ala?Gln?Lys?Lys?Ala?Ala?Trp?Gln?Val

325 330 335

Lys?Phe?Asp?Glu?Trp?Ala?Ala?Ala?Asn?Pro?Glu?Asn?Lys?Ala?Leu?Phe

340 345 350

Asp?Arg?Leu?Asn?Ser?Arg?Glu?Leu?Pro?Ala?Gly?Tyr?Ala?Asp?Glu?Leu

355 360 365

Pro?Thr?Trp?Asp?Ala?Asp?Glu?Lys?Gly?Val?Ala?Thr?Arg?Lys?Ala?Ser

370 375 380

Glu?Ala?Ala?Leu?Gln?Ala?Leu?Gly?Lys?Thr?Leu?Pro?Glu?Leu?Trp?Gly

385 390 395 400

Gly?Ser?Ala?Asp?Leu?Ala?Gly?Ser?Asn?Asn?Thr?Val?Ile?Lys?Gly?Ser

405 410 415

Pro?Ser?Phe?Gly?Pro?Glu?Ser?Ile?Ser?Thr?Glu?Thr?Trp?Ser?Ala?Glu

420 425 430

Pro?Tyr?Gly?Arg?Asn?Leu?His?Phe?Gly?Ile?Arg?Glu?His?Ala?Met?Gly

435 440 445

Ser?Ile?Leu?Asn?Gly?Ile?Ser?Leu?His?Gly?Gly?Thr?Arg?Pro?Tyr?Gly

450 455 460

Gly?Thr?Phe?Leu?Ile?Phe?Ser?Asp?Tyr?Met?Arg?Pro?Ala?Val?Arg?Leu

465 470 475 480

Ala?Ala?Leu?Met?Glu?Thr?Asp?Ala?Tyr?Tyr?Val?Trp?Thr?His?Asp?Ser

485 490 495

Ile?Gly?Leu?Gly?Glu?Asp?Gly?Pro?Thr?His?Gln?Pro?Val?Glu?Thr?Leu

500 505 510

Ala?Ala?Leu?Arg?Ala?Ile?Pro?Gly?Leu?Ser?Val?Leu?Arg?Pro?Ala?Asp

515 520 525

Ala?Asn?Glu?Thr?Ala?Gln?Ala?Trp?Ala?Ala?Ala?Leu?Glu?Tyr?Lys?Glu

530 535 540

Gly?Pro?Lys?Gly?Leu?Ala?Leu?Thr?Arg?Gln?Asn?Val?Pro?Val?Leu?Glu

545 550 555 560

Gly?Thr?Lys?Glu?Lys?Ala?Ala?Glu?Gly?Val?Arg?Arg?Gly?Gly?Tyr?Val

565 570 575

Leu?Val?Glu?Gly?Ser?Lys?Glu?Thr?Pro?Asp?Val?Ile?Leu?Met?Gly?Ser

580 585 590

Gly?Ser?Glu?Val?Gln?Leu?Ala?Val?Asn?Ala?Ala?Lys?Ala?Leu?Glu?Ala

595 600 605

Glu?Gly?Val?Ala?Ala?Arg?Val?Val?Ser?Val?Pro?Cys?Met?Asp?Trp?Phe

610 615 620

Gln?Glu?Gln?Asp?Ala?Glu?Tyr?Ile?Glu?Ser?Val?Leu?Pro?Ala?Ala?Val

625 630 635 640

Thr?Ala?Arg?Val?Ser?Val?Glu?Ala?Gly?Ile?Ala?Met?Pro?Trp?Tyr?Arg

645 650 655

Phe?Leu?Gly?Thr?Gln?Gly?Arg?Ala?Val?Ser?Leu?Glu?His?Phe?Gly?Ala

660 665 670

Ser?Ala?Asp?Tyr?Gln?Thr?Leu?Phe?Glu?Lys?Phe?Gly?Ile?Thr?Thr?Asp

675 680 685

Ala?Val?Val?Ala?Ala?Ala?Lys?Asp?Ser?Ile?Asn?Gly

690 695 700

<210>249

<211>793

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(48)..(770)

<223>RXA00965

<400>249

agattgcggg?cctcggcttc?attgaaaaca?agacggtgtt?tgaataa?atg?aca?act 56

Met?Thr?Thr

1

ttc?cac?gat?ctt?ccg?ctg?gag?gag?cgg?ctg?aca?ctg?gcc?agg?ttg?ggc 104

Phe?His?Asp?Leu?Pro?Leu?Glu?Glu?Arg?Leu?Thr?Leu?Ala?Arg?Leu?Gly

5 10 15

aca?tcc?cac?tac?tcc?cgt?cag?ctc?tcc?ctc?gtg?gac?aac?gct?gag?ttc 152

Thr?Ser?His?Tyr?Ser?Arg?Gln?Leu?Ser?Leu?Val?Asp?Asn?Ala?Glu?Phe

20 25 30 35

ggc?gag?cat?tcc?ctg?cta?gaa?ggg?tgg?act?cgt?tcc?cac?ctc?att?gcc 200

Gly?Glu?His?Ser?Leu?Leu?Glu?Gly?Trp?Thr?Arg?Ser?His?Leu?Ile?Ala

40 45 50

cac?gtg?gca?tac?aac?gcc?atc?gca?ctg?tgc?aac?ctc?atg?cac?tgg?gca 248

His?Val?Ala?Tyr?Asn?Ala?Ile?Ala?Leu?Cys?Asn?Leu?Met?His?Trp?Ala

55 60 65

aat?act?ggt?gag?gaa?acc?cca?atg?tac?gtg?tcg?cca?gaa?gcg?cgc?aac 296

Asn?Thr?Gly?Glu?Glu?Thr?Pro?Met?Tyr?Val?Ser?Pro?Glu?Ala?Arg?Asn

70 75 80

gag?gaa?att?gcc?tac?ggt?tcc?acg?ctc?aat?ccc?gat?gcg?ttg?cgt?aac 344

Glu?Glu?Ile?Ala?Tyr?Gly?Ser?Thr?Leu?Asn?Pro?Asp?Ala?Leu?Arg?Asn

85 90 95

ctg?cat?gaa?cac?tcc?gtc?gca?cgc?ctg?gac?gtg?gct?tgg?cgt?gaa?acg 392

Leu?His?Glu?His?Ser?Val?Ala?Arg?Leu?Asp?Val?Ala?Trp?Arg?Glu?Thr

100 105 110 115

tct?gaa?gat?gct?tgg?tca?cac?gag?gtt?ctg?aca?gct?cag?gga?cgc?act 440

Ser?Glu?Asp?Ala?Trp?Ser?His?Glu?Val?Leu?Thr?Ala?Gln?Gly?Arg?Thr

120 125 130

gtc?cca?gct?agt?gaa?aca?ttg?tgg?atg?cgt?tcc?cgc?gaa?gtc?tgg?atc 488

Val?Pro?Ala?Ser?Glu?Thr?Leu?Trp?Met?Arg?Ser?Arg?Glu?Val?Trp?Ile

135 140 145

cac?gca?gtt?gac?ctc?ggt?gca?gtg?gca?acc?ttt?ggc?gac?atc?cca?gag 536

His?Ala?Val?Asp?Leu?Gly?Ala?Val?Ala?Thr?Phe?Gly?Asp?Ile?Pro?Glu

150 155 160

gtc?atc?ctg?cgc?acc?tta?gct?gca?gaa?atc?aca?caa?aag?tgg?aca?agc 584

Val?Ile?Leu?Arg?Thr?Leu?Ala?Ala?Glu?Ile?Thr?Gln?Lys?Trp?Thr?Ser

165 170 175

caa?gga?gcc?ggc?gag?gga?ctt?gtg?ctt?ctc?gac?gag?ccc?tcc?agc?act 632

Gln?Gly?Ala?Gly?Glu?Gly?Leu?Val?Leu?Leu?Asp?Glu?Pro?Ser?Ser?Thr

180 185 190 195

cgc?tac?ccc?gcc?gcc?cca?ggg?cag?gac?gag?gta?gta?gtg?tcc?ggt?agc 680

Arg?Tyr?Pro?Ala?Ala?Pro?Gly?Gln?Asp?Glu?Val?Val?Val?Ser?Gly?Ser

200 205 210

ctt?gca?ggc?att?gtt?cgc?tac?gcc?gct?ggc?cgc?ggt?tcc?gat?gga?gtc 728

Leu?Ala?Gly?Ile?Val?Arg?Tyr?Ala?Ala?Gly?Arg?Gly?Ser?Asp?Gly?Val

215 220 225

act?tct?tcc?act?gga?gag?gtt?cca?gag?cca?ccg?cgc?tgg?ctg 770

Thr?Ser?Ser?Thr?Gly?Glu?Val?Pro?Glu?Pro?Pro?Arg?Trp?Leu

230 235 240

tagtttccac?acattcttaa?atg 793

<210>250

<211>241

<212>PRT

＜213〉Corynebacterium glutamicum

<400>250

Met?Thr?Thr?Phe?His?Asp?Leu?Pro?Leu?Glu?Glu?Arg?Leu?Thr?Leu?Ala

1 5 10 15

Arg?Leu?Gly?Thr?Ser?His?Tyr?Ser?Arg?Gln?Leu?Ser?Leu?Val?Asp?Asn

20 25 30

Ala?Glu?Phe?Gly?Glu?His?Ser?Leu?Leu?Glu?Gly?Trp?Thr?Arg?Ser?His

35 40 45

Leu?Ile?Ala?His?Val?Ala?Tyr?Asn?Ala?Ile?Ala?Leu?Cys?Asn?Leu?Met

50 55 60

His?Trp?Ala?Asn?Thr?Gly?Glu?Glu?Thr?Pro?Met?Tyr?Val?Ser?Pro?Glu

65 70 75 80

Ala?Arg?Asn?Glu?Glu?Ile?Ala?Tyr?Gly?Ser?Thr?Leu?Asn?Pro?Asp?Ala

85 90 95

Leu?Arg?Asn?Leu?His?Glu?His?Ser?Val?Ala?Arg?Leu?Asp?Val?Ala?Trp

100 105 110

Arg?Glu?Thr?Ser?Glu?Asp?Ala?Trp?Ser?His?Glu?Val?Leu?Thr?Ala?Gln

115 120 125

Gly?Arg?Thr?Val?Pro?Ala?Ser?Glu?Thr?Leu?Trp?Met?Arg?Ser?Arg?Glu

130 135 140

Val?Trp?Ile?His?Ala?Val?Asp?Leu?Gly?Ala?Val?Ala?Thr?Phe?Gly?Asp

145 150 155 160

Ile?Pro?Glu?Val?Ile?Leu?Arg?Thr?Leu?Ala?Ala?Glu?Ile?Thr?Gln?Lys

165 170 175

Trp?Thr?Ser?Gln?Gly?Ala?Gly?Glu?Gly?Leu?Val?Leu?Leu?Asp?Glu?Pro

180 185 190

Ser?Ser?Thr?Arg?Tyr?Pro?Ala?Ala?Pro?Gly?Gln?Asp?Glu?Val?Val?Val

195 200 205

Ser?Gly?Ser?Leu?Ala?Gly?Ile?Val?Arg?Tyr?Ala?Ala?Gly?Arg?Gly?Ser

210 215 220

Asp?Gly?Val?Thr?Ser?Ser?Thr?Gly?Glu?Val?Pro?Glu?Pro?Pro?Arg?Trp

225 230 235 240

Leu

<210>251

<211>1575

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1552)

<223>RXN00999

<400>251

cctcctgtga?cctggtaaaa?tcgccactac?ccccaaatgg?tcacaccttt?taggccgatt?60

ttgctgacac?cgggctatgc?cgtcaagtac?gatcaataac?atg?act?aat?gga?gat 115

Met?Thr?Asn?Gly?Asp

1 5

aat?ctc?gca?cag?atc?ggc?gtt?gta?ggc?cta?gca?gta?atg?ggc?tca?aac 163

Asn?Leu?Ala?Gln?Ile?Gly?Val?Val?Gly?Leu?Ala?Val?Met?Gly?Ser?Asn

10 15 20

ctc?gcc?cgc?aac?ttc?gcc?cgc?aac?ggc?aac?act?gtc?gct?gtc?tac?aac 211

Leu?Ala?Arg?Asn?Phe?Ala?Arg?Asn?Gly?Asn?Thr?Val?Ala?Val?Tyr?Asn

25 30 35

cgc?agc?act?gac?aaa?acc?gac?aag?ctc?atc?gcc?gat?cac?ggc?tcc?gaa 259

Arg?Ser?Thr?Asp?Lys?Thr?Asp?Lys?Leu?Ile?Ala?Asp?His?Gly?Ser?Glu

40 45 50

ggc?aac?ttc?atc?cct?tct?gca?acc?gtc?gaa?gag?ttc?gta?gca?tcc?ctg 307

Gly?Asn?Phe?Ile?Pro?Ser?Ala?Thr?Val?Glu?Glu?Phe?Val?Ala?Ser?Leu

55 60 65

gaa?aag?cca?cgc?cgc?gcc?atc?atc?atg?gtt?cag?gct?ggt?aac?gcc?acc 355

Glu?Lys?Pro?Arg?Arg?Ala?Ile?Ile?Met?Val?Gln?Ala?Gly?Asn?Ala?Thr

70 75 80 85

gac?gca?gtc?atc?aac?cag?ctg?gca?gat?gcc?atg?gac?gaa?ggc?gac?atc 403

Asp?Ala?Val?Ile?Asn?Gln?Leu?Ala?Asp?Ala?Met?Asp?Glu?Gly?Asp?Ile

90 95 100

atc?atc?gac?ggc?ggc?aac?gcc?ctc?tac?acc?gac?acc?att?cgt?cgc?gag 451

Ile?Ile?Asp?Gly?Gly?Asn?Ala?Leu?Tyr?Thr?Asp?Thr?Ile?Arg?Arg?Glu

105 110 115

aag?gaa?atc?tcc?gca?cgc?ggt?ctc?cac?ttc?gtc?ggt?gct?ggt?atc?tcc 499

Lys?Glu?Ile?Ser?Ala?Arg?Gly?Leu?His?Phe?Val?Gly?Ala?Gly?Ile?Ser

120 125 130

ggc?ggc?gaa?gaa?ggc?gca?ctc?aac?ggc?cca?tcc?atc?atg?cct?ggt?ggc 547

Gly?Gly?Glu?Glu?Gly?Ala?Leu?Asn?Gly?Pro?Ser?Ile?Met?Pro?Gly?Gly

135 140 145

cca?gca?aag?tcc?tac?gag?tcc?ctc?gga?cca?ctg?ctt?gag?tcc?atc?gct 595

Pro?Ala?Lys?Ser?Tyr?Glu?Ser?Leu?Gly?Pro?Leu?Leu?Glu?Ser?Ile?Ala

150 155 160 165

gcc?aac?gtt?gac?ggc?acc?cca?tgt?gtc?acc?cac?atc?ggc?cca?gac?ggc 643

Ala?Asn?Val?Asp?Gly?Thr?Pro?Cys?Val?Thr?His?Ile?Gly?Pro?Asp?Gly

170 175 180

gcc?ggc?cac?ttc?gtc?aag?atg?gtc?cac?aac?ggc?atc?gag?tac?gcc?gac 691

Ala?Gly?His?Phe?Val?Lys?Met?Val?His?Asn?Gly?Ile?Glu?Tyr?Ala?Asp

185 190 195

atg?cag?gtc?atc?ggc?gag?gca?tac?cac?ctt?ctc?cgc?tac?gca?gca?ggc 739

Met?Gln?Val?Ile?Gly?Glu?Ala?Tyr?His?Leu?Leu?Arg?Tyr?Ala?Ala?Gly

200 205 210

atg?cag?cca?gct?gaa?atc?gct?gag?gtt?ttc?aag?gaa?tgg?aac?gca?ggc 787

Met?Gln?Pro?Ala?Glu?Ile?Ala?Glu?Val?Phe?Lys?Glu?Trp?Asn?Ala?Gly

215 220 225

gac?ctg?gat?tcc?tac?ctc?atc?gaa?atc?acc?gca?gag?gtt?ctc?tcc?cag 835

Asp?Leu?Asp?Ser?Tyr?Leu?Ile?Glu?Ile?Thr?Ala?Glu?Val?Leu?Ser?Gln

230 235 240 245

gtg?gat?gct?gaa?acc?ggc?aag?cca?cta?atc?gac?gtc?atc?gtt?gac?gct 883

Val?Asp?Ala?Glu?Thr?Gly?Lys?Pro?Leu?Ile?Asp?Val?Ile?Val?Asp?Ala

250 255 260

gca?ggt?cag?aag?ggc?acc?gga?cgt?tgg?acc?gtc?aag?gct?gct?ctt?gat 931

Ala?Gly?Gln?Lys?Gly?Thr?Gly?Arg?Trp?Thr?Val?Lys?Ala?Ala?Leu?Asp

265 270 275

ctg?ggt?att?gct?acc?acc?ggc?atc?ggc?gaa?gct?gtt?ttc?gca?cgt?gca 979

Leu?Gly?Ile?Ala?Thr?Thr?Gly?Ile?Gly?Glu?Ala?Val?Phe?Ala?Arg?Ala

280 285 290

ctc?tcc?ggc?gca?acc?agc?cag?cgc?gct?gca?gca?cag?ggc?aac?cta?cct 1027

Leu?Ser?Gly?Ala?Thr?Ser?Gln?Arg?Ala?Ala?Ala?Gln?Gly?Asn?Leu?Pro

295 300 305

gca?ggt?gtc?ctc?acc?gat?ctg?gaa?gca?ctt?ggc?gtg?gac?aag?gca?cag 1075

Ala?Gly?Val?Leu?Thr?Asp?Leu?Glu?Ala?Leu?Gly?Val?Asp?Lys?Ala?Gln

310 315 320 325

ttc?gtc?gaa?gac?gtt?cgc?cgt?gca?ctg?tac?gca?tcc?aag?ctt?gtt?gct 1123

Phe?Val?Glu?Asp?Val?Arg?Arg?Ala?Leu?Tyr?Ala?Ser?Lys?Leu?Val?Ala

330 335 340

tac?gca?cag?ggc?ttc?gac?gag?atc?aag?gct?ggc?tcc?gac?gag?aac?aac 1171

Tyr?Ala?Gln?Gly?Phe?Asp?Glu?Ile?Lys?Ala?Gly?Ser?Asp?Glu?Asn?Asn

345 350 355

tgg?gac?gtt?gac?cct?cgc?gac?ctc?gct?acc?atc?tgg?cgc?ggc?ggc?tgc 1219

Trp?Asp?Val?Asp?Pro?Arg?Asp?Leu?Ala?Thr?Ile?Trp?Arg?Gly?Gly?Cys

360 365 370

atc?att?cgc?gct?aag?ttc?ctc?aac?cgc?atc?gtc?gaa?gca?tac?gat?gca 1267

Ile?Ile?Arg?Ala?Lys?Phe?Leu?Asn?Arg?Ile?Val?Glu?Ala?Tyr?Asp?Ala

375 380 385

aac?gct?gaa?ctt?gag?tcc?ctg?ctg?ctc?gat?cct?tac?ttc?aag?agc?gag 1315

Asn?Ala?Glu?Leu?Glu?Ser?Leu?Leu?Leu?Asp?Pro?Tyr?Phe?Lys?Ser?Glu

390 395 400 405

ctc?ggc?gac?ctc?atc?gat?tca?tgg?cgt?cgc?gtg?att?gtc?acc?gcc?acc 1363

Leu?Gly?Asp?Leu?Ile?Asp?Ser?Trp?Arg?Arg?Val?Ile?Val?Thr?Ala?Thr

410 415 420

cag?ctt?ggc?ctg?cca?atc?cca?gtg?ttc?gct?tcc?tcc?ctg?tcc?tac?tac 1411

Gln?Leu?Gly?Leu?Pro?Ile?Pro?Val?Phe?Ala?Ser?Ser?Leu?Ser?Tyr?Tyr

425 430 435

gac?agc?ctg?cgt?gca?gag?cgt?ctg?cca?gca?gcc?ctg?atc?caa?gga?cag 1459

Asp?Ser?Leu?Arg?Ala?Glu?Arg?Leu?Pro?Ala?Ala?Leu?Ile?Gln?Gly?Gln

440 445 450

cgc?gac?ttc?ttc?ggt?gcg?cac?acc?tac?aag?cgc?atc?gac?aag?gat?ggc 1507

Arg?Asp?Phe?Phe?Gly?Ala?His?Thr?Tyr?Lys?Arg?Ile?Asp?Lys?Asp?Gly

455 460 465

tcc?ttc?cac?acc?gag?tgg?tcc?ggc?gac?cgc?tcc?gag?gtt?gaa?gct 1552

Ser?Phe?His?Thr?Glu?Trp?Ser?Gly?Asp?Arg?Ser?Glu?Val?Glu?Ala

470 475 480

taaaggctct?ccttttaaca?caa 1575

<210>252

<211>484

<212>PRT

＜213〉Corynebacterium glutamicum

<400>252

Met?Thr?Asn?Gly?Asp?Asn?Leu?Ala?Gln?Ile?Gly?Val?Val?Gly?Leu?Ala

1 5 10 15

Val?Met?Gly?Ser?Asn?Leu?Ala?Arg?Asn?Phe?Ala?Arg?Asn?Gly?Asn?Thr

20 25 30

Val?Ala?Val?Tyr?Asn?Arg?Ser?Thr?Asp?Lys?Thr?Asp?Lys?Leu?Ile?Ala

35 40 45

Asp?His?Gly?Ser?Glu?Gly?Asn?Phe?Ile?Pro?Ser?Ala?Thr?Val?Glu?Glu

50 55 60

Phe?Val?Ala?Ser?Leu?Glu?Lys?Pro?Arg?Arg?Ala?Ile?Ile?Met?Val?Gln

65 70 75 80

Ala?Gly?Asn?Ala?Thr?Asp?Ala?Val?Ile?Asn?Gln?Leu?Ala?Asp?Ala?Met

85 90 95

Asp?Glu?Gly?Asp?Ile?Ile?Ile?Asp?Gly?Gly?Asn?Ala?Leu?Tyr?Thr?Asp

100 105 110

Thr?Ile?Arg?Arg?Glu?Lys?Glu?Ile?Ser?Ala?Arg?Gly?Leu?His?Phe?Val

115 120 125

Gly?Ala?Gly?Ile?Ser?Gly?Gly?Glu?Glu?Gly?Ala?Leu?Asn?Gly?Pro?Ser

130 135 140

Ile?Met?Pro?Gly?Gly?Pro?Ala?Lys?Ser?Tyr?Glu?Ser?Leu?Gly?Pro?Leu

145 150 155 160

Leu?Glu?Ser?Ile?Ala?Ala?Asn?Val?Asp?Gly?Thr?Pro?Cys?Val?Thr?His

165 170 175

Ile?Gly?Pro?Asp?Gly?Ala?Gly?His?Phe?Val?Lys?Met?Val?His?Asn?Gly

180 185 190

Ile?Glu?Tyr?Ala?Asp?Met?Gln?Val?Ile?Gly?Glu?Ala?Tyr?His?Leu?Leu

195 200 205

Arg?Tyr?Ala?Ala?Gly?Met?Gln?Pro?Ala?Glu?Ile?Ala?Glu?Val?Phe?Lys

210 215 220

Glu?Trp?Asn?Ala?Gly?Asp?Leu?Asp?Ser?Tyr?Leu?Ile?Glu?Ile?Thr?Ala

225 230 235 240

Glu?Val?Leu?Ser?Gln?Val?Asp?Ala?Glu?Thr?Gly?Lys?Pro?Leu?Ile?Asp

245 250 255

Val?Ile?Val?Asp?Ala?Ala?Gly?Gln?Lys?Gly?Thr?Gly?Arg?Trp?Thr?Val

260 265 270

Lys?Ala?Ala?Leu?Asp?Leu?Gly?Ile?Ala?Thr?Thr?Gly?Ile?Gly?Glu?Ala

275 280 285

Val?Phe?Ala?Arg?Ala?Leu?Ser?Gly?Ala?Thr?Ser?Gln?Arg?Ala?Ala?Ala

290 295 300

Gln?Gly?Asn?Leu?Pro?Ala?Gly?Val?Leu?Thr?Asp?Leu?Glu?Ala?Leu?Gly

305 310 315 320

Val?Asp?Lys?Ala?Gln?Phe?Val?Glu?Asp?Val?Arg?Arg?Ala?Leu?Tyr?Ala

325 330 335

Ser?Lys?Leu?Val?Ala?Tyr?Ala?Gln?Gly?Phe?Asp?Glu?Ile?Lys?Ala?Gly

340 345 350

Ser?Asp?Glu?Asn?Asn?Trp?Asp?Val?Asp?Pro?Arg?Asp?Leu?Ala?Thr?Ile

355 360 365

Trp?Arg?Gly?Gly?Cys?Ile?Ile?Arg?Ala?Lys?Phe?Leu?Asn?Arg?Ile?Val

370 375 380

Glu?Ala?Tyr?Asp?Ala?Asn?Ala?Glu?Leu?Glu?Ser?Leu?Leu?Leu?Asp?Pro

385 390 395 400

Tyr?Phe?Lys?Ser?Glu?Leu?Gly?Asp?Leu?Ile?Asp?Ser?Trp?Arg?Arg?Val

405 410 415

Ile?Val?Thr?Ala?Thr?Gln?Leu?Gly?Leu?Pro?Ile?Pro?Val?Phe?Ala?Ser

420 425 430

Ser?Leu?Ser?Tyr?Tyr?Asp?Ser?Leu?Arg?Ala?Glu?Arg?Leu?Pro?Ala?Ala

435 440 445

Leu?Ile?Gln?Gly?Gln?Arg?Asp?Phe?Phe?Gly?Ala?His?Thr?Tyr?Lys?Arg

450 455 460

Ile?Asp?Lys?Asp?Gly?Ser?Phe?His?Thr?Glu?Trp?Ser?Gly?Asp?Arg?Ser

465 470 475 480

Glu?Val?Glu?Ala

<210>253

<211>1537

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1537)

<223>FRXA00999

<400>253

cctcctgtga?cctggtaaaa?tcgccactac?ccccaaatgg?tcacaccttt?taggccgatt?60

ttgctgacac?cgggctatgc?cgtcaagtac?gatcaataac?atg?act?aat?gga?gat 115

Met?Thr?Asn?Gly?Asp

1 5

aat?ctc?gca?cag?atc?ggc?gtt?gta?ggc?cta?gca?gta?atg?ggc?tca?aac 163

Asn?Leu?Ala?Gln?Ile?Gly?Val?Val?Gly?Leu?Ala?Val?Met?Gly?Ser?Asn

10 15 20

ctc?gcc?cgc?aac?ttc?gcc?cgc?aac?ggc?aac?act?gtc?gct?gtc?tac?aac 211

Leu?Ala?Arg?Asn?Phe?Ala?Arg?Asn?Gly?Asn?Thr?Val?Ala?Val?Tyr?Asn

25 30 35

cgc?agc?act?gac?aaa?acc?gac?aag?ctc?atc?gcc?gat?cac?ggc?tcc?gaa 259

Arg?Ser?Thr?Asp?Lys?Thr?Asp?Lys?Leu?Ile?Ala?Asp?His?Gly?Ser?Glu

40 45 50

ggc?aac?ttc?atc?cct?tct?gca?acc?gtc?gaa?gag?ttc?gta?gca?tcc?ctg 307

Gly?Asn?Phe?Ile?Pro?Ser?Ala?Thr?Val?Glu?Glu?Phe?Val?Ala?Ser?Leu

55 60 65

gaa?aag?cca?cgc?cgc?gcc?atc?atc?atg?gtt?cag?gct?ggt?aac?gcc?acc 355

Glu?Lys?Pro?Arg?Arg?Ala?Ile?Ile?Met?Val?Gln?Ala?Gly?Asn?Ala?Thr

70 75 80 85

gac?gca?gtc?atc?aac?cag?ctg?gca?gat?gcc?atg?gac?gaa?ggc?gac?atc 403

Asp?Ala?Val?Ile?Asn?Gln?Leu?Ala?Asp?Ala?Met?Asp?Glu?Gly?Asp?Ile

90 95 100

atc?atc?gac?ggc?ggc?aac?gcc?ctc?tac?acc?gac?acc?att?cgt?cgc?gag 451

Ile?Ile?Asp?Gly?Gly?Asn?Ala?Leu?Tyr?Thr?Asp?Thr?Ile?Arg?Arg?Glu

105 110 115

aag?gaa?atc?tcc?gca?cgc?ggt?ctc?cac?ttc?gtc?ggt?gct?ggt?atc?tcc 499

Lys?Glu?Ile?Ser?Ala?Arg?Gly?Leu?His?Phe?Val?Gly?Ala?Gly?Ile?Ser

120 125 130

ggc?ggc?gaa?gaa?ggc?gca?ctc?aac?ggc?cca?tcc?atc?atg?cct?ggt?ggc 547

Gly?Gly?Glu?Glu?Gly?Ala?Leu?Asn?Gly?Pro?Ser?Ile?Met?Pro?Gly?Gly

135 140 145

cca?gca?aag?tcc?tac?gag?tcc?ctc?gga?cca?ctg?ctt?gag?tcc?atc?gct 595

Pro?Ala?Lys?Ser?Tyr?Glu?Ser?Leu?Gly?Pro?Leu?Leu?Glu?Ser?Ile?Ala

150 155 160 165

gcc?aac?gtt?gac?ggc?acc?cca?tgt?gtc?acc?cac?atc?ggc?cca?gac?ggc 643

Ala?Asn?Val?Asp?Gly?Thr?Pro?Cys?Val?Thr?His?Ile?Gly?Pro?Asp?Gly

170 175 180

gcc?ggc?cac?ttc?gtc?aag?atg?gtc?cac?aac?ggc?atc?gag?tac?gcc?gac 691

Ala?Gly?His?Phe?Val?Lys?Met?Val?His?Asn?Gly?Ile?Glu?Tyr?Ala?Asp

185 190 195

atg?cag?gtc?atc?ggc?gag?gca?tac?cac?ctt?ctc?cgc?tac?gca?gca?ggc 739

Met?Gln?Val?Ile?Gly?Glu?Ala?Tyr?His?Leu?Leu?Arg?Tyr?Ala?Ala?Gly

200 205 210

atg?cag?cca?gct?gaa?atc?gct?gag?gtt?ttc?aag?gaa?tgg?aac?gca?ggc 787

Met?Gln?Pro?Ala?Glu?Ile?Ala?Glu?Val?Phe?Lys?Glu?Trp?Asn?Ala?Gly

215 220 225

gac?ctg?gat?tcc?tac?ctc?atc?gaa?atc?acc?gca?gag?gtt?ctc?tcc?cag 835

Asp?Leu?Asp?Ser?Tyr?Leu?Ile?Glu?Ile?Thr?Ala?Glu?Val?Leu?Ser?Gln

230 235 240 245

gtg?gat?gct?gaa?acc?ggc?aag?cca?cta?atc?gac?gtc?atc?gtt?gac?gct 883

Val?Asp?Ala?Glu?Thr?Gly?Lys?Pro?Leu?Ile?Asp?Val?Ile?Val?Asp?Ala

250 255 260

gca?ggt?cag?aag?ggc?acc?gga?cgt?tgg?acc?gtc?aag?gct?gct?ctt?gat 931

Ala?Gly?Gln?Lys?Gly?Thr?Gly?Arg?Trp?Thr?Val?Lys?Ala?Ala?Leu?Asp

265 270 275

ctg?ggt?att?gct?acc?acc?ggc?atc?ggc?gaa?gct?gtt?ttc?gca?cgt?gca 979

Leu?Gly?Ile?Ala?Thr?Thr?Gly?Ile?Gly?Glu?Ala?Val?Phe?Ala?Arg?Ala

280 285 290

ctc?tcc?ggc?gca?acc?agc?cag?cgc?gct?gca?gca?cag?ggc?aac?cta?cct 1027

Leu?Ser?Gly?Ala?Thr?Ser?Gln?Arg?Ala?Ala?Ala?Gln?Gly?Asn?Leu?Pro

295 300 305

gca?ggt?gtc?ctc?acc?gat?ctg?gaa?gca?ctt?ggc?gtg?gac?aag?gca?cag 1075

Ala?Gly?Val?Leu?Thr?Asp?Leu?Glu?Ala?Leu?Gly?Val?Asp?Lys?Ala?Gln

310 315 320 325

ttc?gtc?gaa?gac?gtt?cgc?cgt?gca?ctg?tac?gca?tcc?aag?ctt?gtt?gct 1123

Phe?Val?Glu?Asp?Val?Arg?Arg?Ala?Leu?Tyr?Ala?Ser?Lys?Leu?Val?Ala

330 335 340

tac?gca?cag?ggc?ttc?gac?gag?atc?aag?gct?ggc?tcc?gac?gag?aac?aac 1171

Tyr?Ala?Gln?Gly?Phe?Asp?Glu?Ile?Lys?Ala?Gly?Ser?Asp?Glu?Asn?Asn

345 350 355

tgg?gac?gtt?gac?cct?cgc?gac?ctc?gct?acc?atc?tgg?cgc?ggc?ggc?tgc 1219

Trp?Asp?Val?Asp?Pro?Arg?Asp?Leu?Ala?Thr?Ile?Trp?Arg?Gly?Gly?Cys

360 365 370

atc?att?cgc?gct?aag?ttc?ctc?aac?cgc?atc?gtc?gaa?gca?tac?gat?gca 1267

Ile?Ile?Arg?Ala?Lys?Phe?Leu?Asn?Arg?Ile?Val?Glu?Ala?Tyr?Asp?Ala

375 380 385

aac?gct?gaa?ctt?gag?tcc?ctg?ctg?ctc?gat?cct?tac?ttc?aag?agc?gag 1315

Asn?Ala?Glu?Leu?Glu?Ser?Leu?Leu?Leu?Asp?Pro?Tyr?Phe?Lys?Ser?Glu

390 395 400 405

ctc?ggc?gac?ctc?atc?gat?tca?tgg?cgt?cgc?gtg?att?gtc?acc?gcc?acc 1363

Leu?Gly?Asp?Leu?Ile?Asp?Ser?Trp?Arg?Arg?Val?Ile?Val?Thr?Ala?Thr

410 415 420

cag?ctt?ggc?ctg?cca?atc?cca?gtg?ttc?gct?tcc?tcc?ctg?tcc?tac?tac 1411

Gln?Leu?Gly?Leu?Pro?Ile?Pro?Val?Phe?Ala?Ser?Ser?Leu?Ser?Tyr?Tyr

425 430 435

gac?agc?ctg?cgt?gca?gag?cgt?ctg?cca?gca?gcc?ctg?atc?caa?gga?cag 1459

Asp?Ser?Leu?Arg?Ala?Glu?Arg?Leu?Pro?Ala?Ala?Leu?Ile?Gln?Gly?Gln

440 445 450

cgc?gac?ttc?ttc?ggt?gcg?cac?acc?tac?aag?cgc?atc?gac?aag?gat?ggc 1507

Arg?Asp?Phe?Phe?Gly?Ala?His?Thr?Tyr?Lys?Arg?Ile?Asp?Lys?Asp?Gly

455 460 465

tcc?ttc?cac?acc?gag?tgg?tcc?ggc?gac?cgc 1537

Ser?Phe?His?Thr?Glu?Trp?Ser?Gly?Asp?Arg

470 475

<210>254

<211>479

<212>PRT

＜213〉Corynebacterium glutamicum

<400>254

Met?Thr?Asn?Gly?Asp?Asn?Leu?Ala?Gln?Ile?Gly?Val?Val?Gly?Leu?Ala

1 5 10 15

Val?Met?Gly?Ser?Asn?Leu?Ala?Arg?Asn?Phe?Ala?Arg?Asn?Gly?Asn?Thr

20 25 30

Val?Ala?Val?Tyr?Asn?Arg?Ser?Thr?Asp?Lys?Thr?Asp?Lys?Leu?Ile?Ala

35 40 45

Asp?His?Gly?Ser?Glu?Gly?Asn?Phe?Ile?Pro?Ser?Ala?Thr?Val?Glu?Glu

50 55 60

Phe?Val?Ala?Ser?Leu?Glu?Lys?Pro?Arg?Arg?Ala?Ile?Ile?Met?Val?Gln

65 70 75 80

Ala?Gly?Asn?Ala?Thr?Asp?Ala?Val?Ile?Asn?Gln?Leu?Ala?Asp?Ala?Met

85 90 95

Asp?Glu?Gly?Asp?Ile?Ile?Ile?Asp?Gly?Gly?Asn?Ala?Leu?Tyr?Thr?Asp

100 105 110

Thr?Ile?Arg?Arg?Glu?Lys?Glu?Ile?Ser?Ala?Arg?Gly?Leu?His?Phe?Val

115 120 125

Gly?Ala?Gly?Ile?Ser?Gly?Gly?Glu?Glu?Gly?Ala?Leu?Asn?Gly?Pro?Ser

130 135 140

Ile?Met?Pro?Gly?Gly?Pro?Ala?Lys?Ser?Tyr?Glu?Ser?Leu?Gly?Pro?Leu

145 150 155 160

Leu?Glu?Ser?Ile?Ala?Ala?Asn?Val?Asp?Gly?Thr?Pro?Cys?Val?Thr?His

165 170 175

Ile?Gly?Pro?Asp?Gly?Ala?Gly?His?Phe?Val?Lys?Met?Val?His?Asn?Gly

180 185 190

Ile?Glu?Tyr?Ala?Asp?Met?Gln?Val?Ile?Gly?Glu?Ala?Tyr?His?Leu?Leu

195 200 205

Arg?Tyr?Ala?Ala?Gly?Met?Gln?Pro?Ala?Glu?Ile?Ala?Glu?Val?Phe?Lys

210 215 220

Glu?Trp?Asn?Ala?Gly?Asp?Leu?Asp?Ser?Tyr?Leu?Ile?Glu?Ile?Thr?Ala

225 230 235 240

Glu?Val?Leu?Ser?Gln?Val?Asp?Ala?Glu?Thr?Gly?Lys?Pro?Leu?Ile?Asp

245 250 255

Val?Ile?Val?Asp?Ala?Ala?Gly?Gln?Lys?Gly?Thr?Gly?Arg?Trp?Thr?Val

260 265 270

Lys?Ala?Ala?Leu?Asp?Leu?Gly?Ile?Ala?Thr?Thr?Gly?Ile?Gly?Glu?Ala

275 280 285

Val?Phe?Ala?Arg?Ala?Leu?Ser?Gly?Ala?Thr?Ser?Gln?Arg?Ala?Ala?Ala

290 295 300

Gln?Gly?Asn?Leu?Pro?Ala?Gly?Val?Leu?Thr?Asp?Leu?Glu?Ala?Leu?Gly

305 310 315 320

Val?Asp?Lys?Ala?Gln?Phe?Val?Glu?Asp?Val?Arg?Arg?Ala?Leu?Tyr?Ala

325 330 335

Ser?Lys?Leu?Val?Ala?Tyr?Ala?Gln?Gly?Phe?Asp?Glu?Ile?Lys?Ala?Gly

340 345 350

Ser?Asp?Glu?Asn?Asn?Trp?Asp?Val?Asp?Pro?Arg?Asp?Leu?Ala?Thr?Ile

355 360 365

Trp?Arg?Gly?Gly?Cys?Ile?Ile?Arg?Ala?Lys?Phe?Leu?Asn?Arg?Ile?Val

370 375 380

Glu?Ala?Tyr?Asp?Ala?Asn?Ala?Glu?Leu?Glu?Ser?Leu?Leu?Leu?Asp?Pro

385 390 395 400

Tyr?Phe?Lys?Ser?Glu?Leu?Gly?Asp?Leu?Ile?Asp?Ser?Trp?Arg?Arg?Val

405 410 415

Ile?Val?Thr?Ala?Thr?Gln?Leu?Gly?Leu?Pro?Ile?Pro?Val?Phe?Ala?Ser

420 425 430

Ser?Leu?Ser?Tyr?Tyr?Asp?Ser?Leu?Arg?Ala?Glu?Arg?Leu?Pro?Ala?Ala

435 440 445

Leu?Ile?Gln?Gly?Gln?Arg?Asp?Phe?Phe?Gly?Ala?His?Thr?Tyr?Lys?Arg

450 455 460

Ile?Asp?Lys?Asp?Gly?Ser?Phe?His?Thr?Glu?Trp?Ser?Gly?Asp?Arg

465 470 475

<210>255

<211>1326

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1303)

<223>RXN02596

<400>255

aaggtatctg?ggtgtggata?tgccctgcta?actggagaaa?cttggcccga?tcgggtgtct?60

gaaatttcgg?caacgccgaa?tgtaagttag?tgtcgaatgc?atg?acg?gaa?tcg?aaa 115

Met?Thr?Glu?Ser?Lys

1 5

aat?tac?gac?tta?atc?gtt?gta?ggc?tcc?ggc?ctc?ttc?ggg?ctc?acc?gtg 163

Asn?Tyr?Asp?Leu?Ile?Val?Val?Gly?Ser?Gly?Leu?Phe?Gly?Leu?Thr?Val

10 15 20

gct?gag?cgt?gca?gct?agc?cag?ctg?ggt?aag?aaa?gtc?ctc?atc?gtt?gaa 211

Ala?Glu?Arg?Ala?Ala?Ser?Gln?Leu?Gly?Lys?Lys?Val?Leu?Ile?Val?Glu

25 30 35

cgc?cgc?tcg?cac?ctc?ggt?ggc?aat?gct?tac?tct?gaa?gca?gaa?cca?gag 259

Arg?Arg?Ser?His?Leu?Gly?Gly?Asn?Ala?Tyr?Ser?Glu?Ala?Glu?Pro?Glu

40 45 50

acc?ggc?att?gaa?atc?cac?aaa?tac?ggc?gcg?cac?ctc?ttc?cac?acc?tcc 307

Thr?Gly?Ile?Glu?Ile?His?Lys?Tyr?Gly?Ala?His?Leu?Phe?His?Thr?Ser

55 60 65

aac?aca?cgc?gtg?tgg?gaa?tac?gtc?aac?cag?ttc?acc?agt?ttc?acc?ggc 355

Asn?Thr?Arg?Val?Trp?Glu?Tyr?Val?Asn?Gln?Phe?Thr?Ser?Phe?Thr?Gly

70 75 80 85

tac?cag?cac?cgc?gtc?ttc?gca?atg?cac?aac?ggc?acc?gcc?tac?caa?ttc 403

Tyr?Gln?His?Arg?Val?Phe?Ala?Met?His?Asn?Gly?Thr?Ala?Tyr?Gln?Phe

90 95 100

ccc?atg?gga?ctg?ggc?ctg?att?aac?cag?ttc?ttc?ggc?aag?tac?tac?agc 451

Pro?Met?Gly?Leu?Gly?Leu?Ile?Asn?Gln?Phe?Phe?Gly?Lys?Tyr?Tyr?Ser

105 ll0 115

cca?gat?gaa?gcc?cgt?gag?ctc?atc?aag?gaa?cag?tct?gca?gaa?atc?gat 499

Pro?Asp?Glu?Ala?Arg?Glu?Leu?Ile?Lys?Glu?Gln?Ser?Ala?Glu?Ile?Asp

120 125 130

tcc?tcc?gac?gcc?acc?aac?ctc?gaa?gaa?aag?gcc?att?tcc?ctc?att?ggt 547

Ser?Ser?Asp?Ala?Thr?Asn?Leu?Glu?Glu?Lys?Ala?Ile?Ser?Leu?Ile?Gly

135 140 145

cgc?cca?ctt?tac?gag?gca?ttc?atc?cgc?gac?tac?acc?gca?aag?cag?tgg 595

Arg?Pro?Leu?Tyr?Glu?Ala?Phe?Ile?Arg?Asp?Tyr?Thr?Ala?Lys?Gln?Trp

150 155 160 165

cag?act?gat?cca?aag?aac?ctc?cca?gcc?ggc?aac?atc?acc?cgc?ctg?cca 643

Gln?Thr?Asp?Pro?Lys?Asn?Leu?Pro?Ala?Gly?Asn?Ile?Thr?Arg?Leu?Pro

170 175 180

gtt?cgc?tac?aac?ttc?aac?aac?cgc?tat?ttc?aac?gac?acc?tac?gaa?ggc 691

Val?Arg?Tyr?Asn?Phe?Asn?Asn?Arg?Tyr?Phe?Asn?Asp?Thr?Tyr?Glu?Gly

185 190 195

ctt?ccc?aca?gac?ggc?tac?gcg?gca?tgg?ttg?gaa?aag?atg?gca?gag?cat 739

Leu?Pro?Thr?Asp?Gly?Tyr?Ala?Ala?Trp?Leu?Glu?Lys?Met?Ala?Glu?His

200 205 210

gag?ctt?atc?gac?gtc?cgc?ctc?gac?acc?gac?tgg?ttc?gac?gtt?cgc?gat 787

Glu?Leu?Ile?Asp?Val?Arg?Leu?Asp?Thr?Asp?Trp?Phe?Asp?Val?Arg?Asp

215 220 225

gac?ctc?cgc?gca?agc?aac?ccc?gac?gca?cct?gtg?gtc?tac?acc?ggc?cca 835

Asp?Leu?Arg?Ala?Ser?Asn?Pro?Asp?Ala?Pro?Val?Val?Tyr?Thr?Gly?Pro

230 235 240 245

ctc?gac?ctc?tac?ttc?aac?tac?gca?gag?ggc?aag?ctg?gga?tgg?cgc?acc 883

Leu?Asp?Leu?Tyr?Phe?Asn?Tyr?Ala?Glu?Gly?Lys?Leu?Gly?Trp?Arg?Thr

250 255 260

ctc?gac?ttt?gaa?acc?gaa?gta?gta?gaa?acc?ggt?gac?ttc?caa?gga?acc 931

Leu?Asp?Phe?Glu?Thr?Glu?Val?Val?Glu?Thr?Gly?Asp?Phe?Gln?Gly?Thr

265 270 275

cca?gtg?atg?aac?tac?aac?gat?gcg?gac?gta?cct?ttc?acc?cgc?atc?cac 979

Pro?Val?Met?Asn?Tyr?Asn?Asp?Ala?Asp?Val?Pro?Phe?Thr?Arg?Ile?His

280 285 290

gag?ttc?cgt?cac?ttc?cac?cca?gag?cgt?gat?gac?agt?tac?ccc?aag?gat 1027

Glu?Phe?Arg?His?Phe?His?Pro?Glu?Arg?Asp?Asp?Ser?Tyr?Pro?Lys?Asp

295 300 305

aag?acc?gtc?atc?atg?cgc?gag?ttc?tcc?cgt?ttc?gca?gat?aac?gag?gat 1075

Lys?Thr?Val?Ile?Met?Arg?Glu?Phe?Ser?Arg?Phe?Ala?Asp?Asn?Glu?Asp

310 315 320 325

gag?cct?tat?tac?cca?atc?aac?act?cca?gac?gac?cga?gac?atg?ctg?aag 1123

Glu?Pro?Tyr?Tyr?Pro?Ile?Asn?Thr?Pro?Asp?Asp?Arg?Asp?Met?Leu?Lys

330 335 340

cag?tac?cgc?ctt?ctg?gct?gct?gaa?gag?gct?gct?aat?aat?aag?gtg?ctg 1171

Gln?Tyr?Arg?Leu?Leu?Ala?Ala?Glu?Glu?Ala?Ala?Asn?Asn?Lys?Val?Leu

345 350 355

ttc?ggc?ggt?cga?ctg?ggc?acg?tac?cag?tac?ctc?gac?atg?cac?atg?gct 1219

Phe?Gly?Gly?Arg?Leu?Gly?Thr?Tyr?Gln?Tyr?Leu?Asp?Met?His?Met?Ala

360 365 370

atc?ggt?tct?gcg?ctg?agc?atg?ttt?gac?aac?aag?ctg?gtg?ccg?ttc?ttt 1267

Ile?Gly?Ser?Ala?Leu?Ser?Met?Phe?Asp?Asn?Lys?Leu?Val?Pro?Phe?Phe

375 380 385

gaa?gaa?ggc?aca?ccg?cta?gag?cag?gaa?cgc?gga?cac?taaaaggaag 1313

Glu?Glu?Gly?Thr?Pro?Leu?Glu?Gln?Glu?Arg?Gly?His

390 395 400

ggcatctccc?aca 1326

<210>256

<211>401

<212>PRT

＜213〉Corynebacterium glutamicum

<400>256

Met?Thr?Glu?Ser?Lys?Asn?Tyr?Asp?Leu?Ile?Val?Val?Gly?Ser?Gly?Leu

1 5 10 15

Phe?Gly?Leu?Thr?Val?Ala?Glu?Arg?Ala?Ala?Ser?Gln?Leu?Gly?Lys?Lys

20 25 30

Val?Leu?Ile?Val?Glu?Arg?Arg?Ser?His?Leu?Gly?Gly?Asn?Ala?Tyr?Ser

35 40 45

Glu?Ala?Glu?Pro?Glu?Thr?Gly?Ile?Glu?Ile?His?Lys?Tyr?Gly?Ala?His

50 55 60

Leu?Phe?His?Thr?Ser?Asn?Thr?Arg?Val?Trp?Glu?Tyr?Val?Asn?Gln?Phe

65 70 75 80

Thr?Ser?Phe?Thr?Gly?Tyr?Gln?His?Arg?Val?Phe?Ala?Met?His?Asn?Gly

85 90 95

Thr?Ala?Tyr?Gln?Phe?Pro?Met?Gly?Leu?Gly?Leu?Ile?Asn?Gln?Phe?Phe

100 105 110

Gly?Lys?Tyr?Tyr?Ser?Pro?Asp?Glu?Ala?Arg?Glu?Leu?Ile?Lys?Glu?Gln

115 120 125

Ser?Ala?Glu?Ile?Asp?Ser?Ser?Asp?Ala?Thr?Asn?Leu?Glu?Glu?Lys?Ala

130 135 140

Ile?Ser?Leu?Ile?Gly?Arg?Pro?Leu?Tyr?Glu?Ala?Phe?Ile?Arg?Asp?Tyr

145 150 155 160

Thr?Ala?Lys?Gln?Trp?Gln?Thr?Asp?Pro?Lys?Asn?Leu?Pro?Ala?Gly?Asn

165 170 175

Ile?Thr?Arg?Leu?Pro?Val?Arg?Tyr?Asn?Phe?Asn?Asn?Arg?Tyr?Phe?Asn

180 185 190

Asp?Thr?Tyr?Glu?Gly?Leu?Pro?Thr?Asp?Gly?Tyr?Ala?Ala?Trp?Leu?Glu

195 200 205

Lys?Met?Ala?Glu?His?Glu?Leu?Ile?Asp?Val?Arg?Leu?Asp?Thr?Asp?Trp

210 215 220

Phe?Asp?Val?Arg?Asp?Asp?Leu?Arg?Ala?Ser?Asn?Pro?Asp?Ala?Pro?Val

225 230 235 240

Val?Tyr?Thr?Gly?Pro?Leu?Asp?Leu?Tyr?Phe?Asn?Tyr?Ala?Glu?Gly?Lys

245 250 255

Leu?Gly?Trp?Arg?Thr?Leu?Asp?Phe?Glu?Thr?Glu?Val?Val?Glu?Thr?Gly

260 265 270

Asp?Phe?Gln?Gly?Thr?Pro?Val?Met?Asn?Tyr?Asn?Asp?Ala?Asp?Val?Pro

275 280 285

Phe?Thr?Arg?Ile?His?Glu?Phe?Arg?His?Phe?His?Pro?Glu?Arg?Asp?Asp

290 295 300

Ser?Tyr?Pro?Lys?Asp?Lys?Thr?Val?Ile?Met?Arg?Glu?Phe?Ser?Arg?Phe

305 310 315 320

Ala?Asp?Asn?Glu?Asp?Glu?Pro?Tyr?Tyr?Pro?Ile?Asn?Thr?Pro?Asp?Asp

325 330 335

Arg?Asp?Met?Leu?Lys?Gln?Tyr?Arg?Leu?Leu?Ala?Ala?Glu?Glu?Ala?Ala

340 345 350

Asn?Asn?Lys?Val?Leu?Phe?Gly?Gly?Arg?Leu?Gly?Thr?Tyr?Gln?Tyr?Leu

355 360 365

Asp?Met?His?Met?Ala?Ile?Gly?Ser?Ala?Leu?Ser?Met?Phe?Asp?Asn?Lys

370 375 380

Leu?Val?Pro?Phe?Phe?Glu?Glu?Gly?Thr?Pro?Leu?Glu?Gln?Glu?Arg?Gly

385 390 395 400

His

<210>257

<211>512

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(489)

<223>FRXA02596

<400>257

cct?gtg?gtc?tac?acc?ggc?cca?ctc?gac?ctc?tac?ttc?aac?tac?gca?gag 48

Pro?Val?Val?Tyr?Thr?Gly?Pro?Leu?Asp?Leu?Tyr?Phe?Asn?Tyr?Ala?Glu

1 5 10 15

ggc?aag?ctg?gga?tgg?cgc?acc?ctc?gac?ttt?gaa?acc?gaa?gta?gta?gaa 96

Gly?Lys?Leu?Gly?Trp?Arg?Thr?Leu?Asp?Phe?Glu?Thr?Glu?Val?Val?Glu

20 25 30

acc?ggt?gac?ttc?caa?gga?acc?cca?gtg?atg?aac?tac?aac?gat?gcg?gac 144

Thr?Gly?Asp?Phe?Gln?Gly?Thr?Pro?Val?Met?Asn?Tyr?Asn?Asp?Ala?Asp

35 40 45

gta?cct?ttc?acc?cgc?atc?cac?gag?ttc?cgt?cac?ttc?cac?cca?gag?cgt 192

Val?Pro?Phe?Thr?Arg?Ile?His?Glu?Phe?Arg?His?Phe?His?Pro?Glu?Arg

50 55 60

gat?gac?agt?tac?ccc?aag?gat?aag?acc?gtc?atc?atg?cgc?gag?ttc?tcc 240

Asp?Asp?Ser?Tyr?Pro?Lys?Asp?Lys?Thr?Val?Ile?Met?Arg?Glu?Phe?Ser

65 70 75 80

cgt?ttc?gca?gat?aac?gag?gat?gag?cct?tat?tac?cca?atc?aac?act?cca 288

Arg?Phe?Ala?Asp?Asn?Glu?Asp?Glu?Pro?Tyr?Tyr?Pro?Ile?Asn?Thr?Pro

85 90 95

gac?gac?cga?gac?atg?ctg?aag?cag?tac?cgc?ctt?ctg?gct?gct?gaa?gag 336

Asp?Asp?Arg?Asp?Met?Leu?Lys?Gln?Tyr?Arg?Leu?Leu?Ala?Ala?Glu?Glu

100 105 110

gct?gct?aat?aat?aag?gtg?ctg?ttc?ggc?ggt?cga?ctg?ggc?acg?tac?cag 384

Ala?Ala?Asn?Asn?Lys?Val?Leu?Phe?Gly?Gly?Arg?Leu?Gly?Thr?Tyr?Gln

115 120 125

tac?ctc?gac?atg?cac?atg?gct?atc?ggt?tct?gcg?ctg?agc?atg?ttt?gac 432

Tyr?Leu?Asp?Met?His?Met?Ala?Ile?Gly?Ser?Ala?Leu?Ser?Met?Phe?Asp

130 135 140

aac?aag?ctg?gtg?ccg?ttc?ttt?gaa?gaa?ggc?aca?ccg?cta?gag?cag?gaa 480

Asn?Lys?Leu?Val?Pro?Phe?Phe?Glu?Glu?Gly?Thr?Pro?Leu?Glu?Gln?Glu

145 150 155 160

cgc?gga?cac?taaaaggaag?ggcatctccc?aca 512

Arg?Gly?His

<210>258

<211>163

<212>PRT

＜213〉Corynebacterium glutamicum

<400>258

Pro?Val?Val?Tyr?Thr?Gly?Pro?Leu?Asp?Leu?Tyr?Phe?Asn?Tyr?Ala?Glu

1 5 10 15

Gly?Lys?Leu?Gly?Trp?Arg?Thr?Leu?Asp?Phe?Glu?Thr?Glu?Val?Val?Glu

20 25 30

Thr?Gly?Asp?Phe?Gln?Gly?Thr?Pro?Val?Met?Asn?Tyr?Asn?Asp?Ala?Asp

35 40 45

Val?Pro?Phe?Thr?Arg?Ile?His?Glu?Phe?Arg?His?Phe?His?Pro?Glu?Arg

50 55 60

Asp?Asp?Ser?Tyr?Pro?Lys?Asp?Lys?Thr?Val?Ile?Met?Arg?Glu?Phe?Ser

65 70 75 80

Arg?Phe?Ala?Asp?Asn?Glu?Asp?Glu?Pro?Tyr?Tyr?Pro?Ile?Asn?Thr?Pro

85 90 95

Asp?Asp?Arg?Asp?Met?Leu?Lys?Gln?Tyr?Arg?Leu?Leu?Ala?Ala?Glu?Glu

100 105 110

Ala?Ala?Asn?Asn?Lys?Val?Leu?Phe?Gly?Gly?Arg?Leu?Gly?Thr?Tyr?Gln

115 120 125

Tyr?Leu?Asp?Met?His?Met?Ala?Ile?Gly?Ser?Ala?Leu?Ser?Met?Phe?Asp

130 135 140

Asn?Lys?Leu?Val?Pro?Phe?Phe?Glu?Glu?Gly?Thr?Pro?Leu?Glu?Gln?Glu

145 150 155 160

Arg?Gly?His

<210>259

<211>598

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(598)

<223>FRXA02642

<400>259

aaggtatctg?ggtgtggata?tgccctgcta?actggagaaa?cttggcccga?tcgggtgtct?60

gaaatttcgg?caacgccgaa?tgtaagttag?tgtcgaatgc?atg?acg?gaa?tcg?aaa 115

Met?Thr?Glu?Ser?Lys

1 5

aat?tac?gac?tta?atc?gtt?gta?ggc?tcc?ggc?ctc?ttc?ggg?ctc?acc?gtg 163

Asn?Tyr?Asp?Leu?Ile?Val?Val?Gly?Ser?Gly?Leu?Phe?Gly?Leu?Thr?Val

10 15 20

gct?gag?cgt?gca?gct?agc?cag?ctg?ggt?aag?aaa?gtc?ctc?atc?gtt?gaa 211

Ala?Glu?Arg?Ala?Ala?Ser?Gln?Leu?Gly?Lys?Lys?Val?Leu?Ile?Val?Glu

25 30 35

cgc?cgc?tcg?cac?ctc?ggt?ggc?aat?gct?tac?tct?gaa?gca?gaa?cca?gag 259

Arg?Arg?Ser?His?Leu?Gly?Gly?Asn?Ala?Tyr?Ser?Glu?Ala?Glu?Pro?Glu

40 45 50

acc?ggc?att?gaa?atc?cac?aaa?tac?ggc?gcg?cac?ctc?ttc?cac?acc?tcc 307

Thr?Gly?Ile?Glu?Ile?His?Lys?Tyr?Gly?Ala?His?Leu?Phe?His?Thr?Ser

55 60 65

aac?aca?cgc?gtg?tgg?gaa?tac?gtc?aac?cag?ttc?acc?agt?ttc?acc?ggc 355

Asn?Thr?Arg?Val?Trp?Glu?Tyr?Val?Asn?Gln?Phe?Thr?Ser?Phe?Thr?Gly

70 75 80 85

tac?cag?cac?cgc?gtc?ttc?gca?atg?cac?aac?ggc?acc?gcc?tac?caa?ttc 403

Tyr?Gln?His?Arg?Val?Phe?Ala?Met?His?Asn?Gly?Thr?Ala?Tyr?Gln?Phe

90 95 100

ccc?atg?gga?ctg?ggc?ctg?att?aac?cag?ttc?ttc?ggc?aag?tac?tac?agc 451

Pro?Met?Gly?Leu?Gly?Leu?Ile?Asn?Gln?Phe?Phe?Gly?Lys?Tyr?Tyr?Ser

105 110 115

cca?gat?gaa?gcc?cgt?gag?ctc?atc?aag?gaa?cag?tct?gca?gaa?atc?gat 499

Pro?Asp?Glu?Ala?Arg?Glu?Leu?Ile?Lys?Glu?Gln?Ser?Ala?Glu?Ile?Asp

120 125 130

tcc?tcc?gac?gcc?acc?aac?ctc?gaa?gaa?aag?gcc?att?tcc?ctc?att?ggt 547

Ser?Ser?Asp?Ala?Thr?Asn?Leu?Glu?Glu?Lys?Ala?Ile?Ser?Leu?Ile?Gly

135 140 145

cgc?cca?ctt?tac?gag?gca?ttc?atc?cgc?gac?tac?acc?gca?aag?cag?tgg 595

Arg?Pro?Leu?Tyr?Glu?Ala?Phe?Ile?Arg?Asp?Tyr?Thr?Ala?Lys?Gln?Trp

150 155 160 165

cag 598

Gln

<210>260

<211>166

<212>PRT

＜213〉Corynebacterium glutamicum

<400>260

Met?Thr?Glu?Ser?Lys?Asn?Tyr?Asp?Leu?Ile?Val?Val?Gly?Ser?Gly?Leu

1 5 10 15

Phe?Gly?Leu?Thr?Val?Ala?Glu?Arg?Ala?Ala?Ser?Gln?Leu?Gly?Lys?Lys

20 25 30

Val?Leu?Ile?Val?Glu?Arg?Arg?Ser?His?Leu?Gly?Gly?Asn?Ala?Tyr?Ser

35 40 45

Glu?Ala?Glu?Pro?Glu?Thr?Gly?Ile?Glu?Ile?His?Lys?Tyr?Gly?Ala?His

50 55 60

Leu?Phe?His?Thr?Ser?Asn?Thr?Arg?Val?Trp?Glu?Tyr?Val?Asn?Gln?Phe

65 70 75 80

Thr?Ser?Phe?Thr?Gly?Tyr?Gln?His?Arg?Val?Phe?Ala?Met?His?Asn?Gly

85 90 95

Thr?Ala?Tyr?Gln?Phe?Pro?Met?Gly?Leu?Gly?Leu?Ile?Asn?Gln?Phe?Phe

100 105 110

Gly?Lys?Tyr?Tyr?Ser?Pro?Asp?Glu?Ala?Arg?Glu?Leu?Ile?Lys?Glu?Gln

115 120 125

Ser?Ala?Glu?Ile?Asp?Ser?Ser?Asp?Ala?Thr?Asn?Leu?Glu?Glu?Lys?Ala

130 135 140

Ile?Ser?Leu?Ile?Gly?Arg?Pro?Leu?Tyr?Glu?Ala?Phe?Ile?Arg?Asp?Tyr

145 150 155 160

Thr?Ala?Lys?Gln?Trp?Gln

165

<210>261

<211>668

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(645)

<223>RXA02572

<400>261

gcg?gtc?gct?gag?att?tgc?gag?ccg?acc?ggc?gcc?gat?gcg?gtt?gcg?ctt 48

Ala?Val?Ala?Glu?Ile?Cys?Glu?Pro?Thr?Gly?Ala?Asp?Ala?Val?Ala?Leu

1 5 10 15

gtg?gat?gcc?atc?ggt?cac?gac?gat?cgt?atc?ggc?cga?aag?ttc?tta?ggc 96

Val?Asp?Ala?Ile?Gly?His?Asp?Asp?Arg?Ile?Gly?Arg?Lys?Phe?Leu?Gly

20 25 30

gcg?ggc?ctg?gga?ttc?ggt?ggc?ggt?tgt?ttg?cct?aaa?gac?atc?cgc?gct 144

Ala?Gly?Leu?Gly?Phe?Gly?Gly?Gly?Cys?Leu?Pro?Lys?Asp?Ile?Arg?Ala

35 40 45

ttc?atg?gca?cgc?gcg?ggc?gaa?ttg?ggt?gct?gac?cag?gca?tta?acg?ttc 192

Phe?Met?Ala?Arg?Ala?Gly?Glu?Leu?Gly?Ala?Asp?Gln?Ala?Leu?Thr?Phe

50 55 60

ttg?cgt?gag?gtc?gat?tcc?atc?aat?atg?cgt?cgt?cgc?gac?cgt?gtg?gtg 240

Leu?Arg?Glu?Val?Asp?Ser?Ile?Asn?Met?Arg?Arg?Arg?Asp?Arg?Val?Val

65 70 75 80

cag?ctg?gcc?aaa?gag?atg?tgt?ggc?ggt?tcg?ctg?ctg?ggc?aag?cgg?gtt 288

Gln?Leu?Ala?Lys?Glu?Met?Cys?Gly?Gly?Ser?Leu?Leu?Gly?Lys?Arg?Val

85 90 95

aca?gtg?ctc?ggc?gcc?gca?ttc?aaa?ccc?aac?tcg?gac?gat?gtc?cgc?gat 336

Thr?Val?Leu?Gly?Ala?Ala?Phe?Lys?Pro?Asn?Ser?Asp?Asp?Val?Arg?Asp

100 105 110

tct?ccg?gcg?ctg?tcg?gtc?gcg?ggt?tcg?ctg?tcg?ctc?cag?ggt?gcg?gcg 384

Ser?Pro?Ala?Leu?Ser?Val?Ala?Gly?Ser?Leu?Ser?Leu?Gln?Gly?Ala?Ala

115 120 125

gtc?tcg?gtc?tac?gac?ccg?gaa?gct?atg?gac?aac?gct?cga?cgc?gtc?ttc 432

Val?Ser?Val?Tyr?Asp?Pro?Glu?Ala?Met?Asp?Asn?Ala?Arg?Arg?Val?Phe

130 135 140

ccg?acg?ctc?agc?tat?gcg?tcc?agc?act?aaa?gag?gcg?ctt?atc?gac?gcc 480

Pro?Thr?Leu?Ser?Tyr?Ala?Ser?Ser?Thr?Lys?Glu?Ala?Leu?Ile?Asp?Ala

145 150 155 160

cac?ctc?gtc?gtt?ctt?gcc?act?gaa?tgg?caa?gaa?ttc?cgc?gac?ctt?gac 528

His?Leu?Val?Val?Leu?Ala?Thr?Glu?Trp?Gln?Glu?Phe?Arg?Asp?Leu?Asp

165 170 175

ccc?gaa?gtg?gcg?gga?ggg?gtc?gtc?gag?aag?cgc?gct?att?att?gat?ggc 576

Pro?Glu?Val?Ala?Gly?Gly?Val?Val?Glu?Lys?Arg?Ala?Ile?Ile?Asp?Gly

180 185 190

cga?aac?gtc?ctc?gat?gtt?gcc?aaa?tgg?aag?gcc?gcc?ggt?tgg?gaa?atg 624

Arg?Asn?Val?Leu?Asp?Val?Ala?Lys?Trp?Lys?Ala?Ala?Gly?Trp?Glu?Met

195 200 205

gaa?gcg?ctc?ggc?cgc?aac?ctt?tagtgcggtg?gatcaggcgg?ggc 668

Glu?Ala?Leu?Gly?Arg?Asn?Leu

210 215

<210>262

<211>215

<212>PRT

＜213〉Corynebacterium glutamicum

<400>262

Ala?Val?Ala?Glu?Ile?Cys?Glu?Pro?Thr?Gly?Ala?Asp?Ala?Val?Ala?Leu

1 5 10 15

Val?Asp?Ala?Ile?Gly?His?Asp?Asp?Arg?Ile?Gly?Arg?Lys?Phe?Leu?Gly

20 25 30

Ala?Gly?Leu?Gly?Phe?Gly?Gly?Gly?Cys?Leu?Pro?Lys?Asp?Ile?Arg?Ala

35 40 45

Phe?Met?Ala?Arg?Ala?Gly?Glu?Leu?Gly?Ala?Asp?Gln?Ala?Leu?Thr?Phe

50 55 60

Leu?Arg?Glu?Val?Asp?Ser?Ile?Asn?Met?Arg?Arg?Arg?Asp?Arg?Val?Val

65 70 75 80

Gln?Leu?Ala?Lys?Glu?Met?Cys?Gly?Gly?Ser?Leu?Leu?Gly?Lys?Arg?Val

85 90 95

Thr?Val?Leu?Gly?Ala?Ala?Phe?Lys?Pro?Asn?Ser?Asp?Asp?Val?Arg?Asp

100 105 110

Ser?Pro?Ala?Leu?Ser?Val?Ala?Gly?Ser?Leu?Ser?Leu?Gln?Gly?Ala?Ala

115 120 125

Val?Ser?Val?Tyr?Asp?Pro?Glu?Ala?Met?Asp?Asn?Ala?Arg?Arg?Val?Phe

130 135 140

Pro?Thr?Leu?Ser?Tyr?Ala?Ser?Ser?Thr?Lys?Glu?Ala?Leu?Ile?Asp?Ala

145 150 155 160

His?Leu?Val?Val?Leu?Ala?Thr?Glu?Trp?Gln?Glu?Phe?Arg?Asp?Leu?Asp

165 170 175

Pro?Glu?Val?Ala?Gly?Gly?Val?Val?Glu?Lys?Arg?Ala?Ile?Ile?Asp?Gly

180 185 190

Arg?Asn?Val?Leu?Asp?Val?Ala?Lys?Trp?Lys?Ala?Ala?Gly?Trp?Glu?Met

195 200 205

Glu?Ala?Leu?Gly?Arg?Asn?Leu

210 215

<210>263

<211>1224

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1201)

<223>RXA02485

<400>263

cggtggtcag?tgcttggtgc?accttgccga?cgggctgatt?gatcgtaatg?gtgttttctg?60

tacgcgttgc?catgaggata?agactaccgt?tagtggggtg?ttg?gat?tca?tcg?cta 115

Leu?Asp?Ser?Ser?Leu

1 5

gcc?cag?gaa?atc?gcc?gcg?atc?gac?ggc?gtc?gaa?ctc?gat?tcg?gaa?gtc 163

Ala?Gln?Glu?Ile?Ala?Ala?Ile?Asp?Gly?Val?Glu?Leu?Asp?Ser?Glu?Val

10 15 20

act?ttc?gcc?gat?ctg?acg?acc?ctc?cgc?atc?ggc?gga?aaa?ccc?cgc?agc 211

Thr?Phe?Ala?Asp?Leu?Thr?Thr?Leu?Arg?Ile?Gly?Gly?Lys?Pro?Arg?Ser

25 30 35

gcc?gta?cgt?tgc?cag?acc?acg?gag?gcg?ctg?gtc?agc?gcc?ata?aaa?ttg 259

Ala?Val?Arg?Cys?Gln?Thr?Thr?Glu?Ala?Leu?Val?Ser?Ala?Ile?Lys?Leu

40 45 50

ctt?gac?gac?gcc?tcc?ctc?ccc?ctc?ctc?att?gtc?ggc?ggc?ggg?tcc?aat 307

Leu?Asp?Asp?Ala?Ser?Leu?Pro?Leu?Leu?Ile?Val?Gly?Gly?Gly?Ser?Asn

55 60 65

ctc?gtc?gtg?gcc?gac?ggc?gat?ctg?gat?gtt?att?gcc?gtc?atc?atc?gaa 355

Leu?Val?Val?Ala?Asp?Gly?Asp?Leu?Asp?Val?Ile?Ala?Val?Ile?Ile?Glu

70 75 80 85

acc?gac?gac?gtc?tcc?atc?aac?ctc?acc?gac?ggt?ctc?ctc?acc?gcc?gat 403

Thr?Asp?Asp?Val?Ser?Ile?Asn?Leu?Thr?Asp?Gly?Leu?Leu?Thr?Ala?Asp

90 95 100

gca?ggc?gct?gtt?tgg?gac?gat?gtt?gtc?cac?ctt?tcg?gtg?gat?gcc?ggc 451

Ala?Gly?Ala?Val?Trp?Asp?Asp?Val?Val?His?Leu?Ser?Val?Asp?Ala?Gly

105 110 115

ctc?ggt?gga?att?gaa?tgc?ctc?tcc?gga?atc?ccc?ggc?tcc?gcc?ggc?gcc 499

Leu?Gly?Gly?Ile?Glu?Cys?Leu?Ser?Gly?Ile?Pro?Gly?Ser?Ala?Gly?Ala

120 125 130

acc?cca?gtc?caa?aac?gtg?ggc?gcc?tac?ggc?acg?gaa?gtt?tcc?gat?gta 547

Thr?Pro?Val?Gln?Asn?Val?Gly?Ala?Tyr?Gly?Thr?Glu?Val?Ser?Asp?Val

135 140 145

ctc?acc?cgc?gtc?cag?ctt?ctc?gac?cgc?acc?acc?cac?caa?gtc?tcc?tgg 595

Leu?Thr?Arg?Val?Gln?Leu?Leu?Asp?Arg?Thr?Thr?His?Gln?Val?Ser?Trp

150 155 160 165

gtc?gac?gcc?tcc?gaa?ctc?gac?ctc?tct?tac?cga?tac?tcc?aat?ctc?aaa 643

Val?Asp?Ala?Ser?Glu?Leu?Asp?Leu?Ser?Tyr?Arg?Tyr?Ser?Asn?Leu?Lys

170 175 180

ttc?acc?aac?cgc?gca?gtc?gtc?ttg?gcg?atc?gaa?ctc?cag?ctc?ctc?acc 691

Phe?Thr?Asn?Arg?Ala?Val?Val?Leu?Ala?Ile?Glu?Leu?Gln?Leu?Leu?Thr

185 190 195

gac?gga?ttg?tcc?gcg?ccg?cta?cgt?ttt?ggt?gaa?ttg?gga?cgt?cga?tta 739

Asp?Gly?Leu?Ser?Ala?Pro?Leu?Arg?Phe?Gly?Glu?Leu?Gly?Arg?Arg?Leu

200 205 210

gcg?atc?tcc?gag?gcc?gaa?ccc?cac?cca?cgt?cgc?ccc?gtc?cgc?atg?gtc 787

Ala?Ile?Ser?Glu?Ala?Glu?Pro?His?Pro?Arg?Arg?Pro?Val?Arg?Met?Val

215 220 225

cgc?gac?gcc?gtc?cta?gaa?ctc?cgc?cgc?gcc?aaa?ggc?atg?gtc?gtg?gaa 835

Arg?Asp?Ala?Val?Leu?Glu?Leu?Arg?Arg?Ala?Lys?Gly?Met?Val?Val?Glu

230 235 240 245

cac?acc?gac?cac?gac?acc?tgg?tcc?gcc?gga?tcc?ttc?ttc?acc?aac?cca 883

His?Thr?Asp?His?Asp?Thr?Trp?Ser?Ala?Gly?Ser?Phe?Phe?Thr?Asn?Pro

250 255 260

atc?gtc?gac?cca?gcc?ctt?gcc?gac?gca?gtc?ttt?gaa?aaa?gtc?ggc?gaa 931

Ile?Val?Asp?Pro?Ala?Leu?Ala?Asp?Ala?Val?Phe?Glu?Lys?Val?Gly?Glu

265 270 275

ccc?acc?atg?ccc?cgc?ttc?cca?gcc?ggc?gat?ggc?aaa?gaa?aaa?ctc?tcc 979

Pro?Thr?Met?Pro?Arg?Phe?Pro?Ala?Gly?Asp?Gly?Lys?Glu?Lys?Leu?Ser

280 285 290

gca?gcc?tgg?ctc?atc?gaa?cgc?gcc?ggc?ttc?aaa?aag?gga?cac?ccc?ggc 1027

Ala?Ala?Trp?Leu?Ile?Glu?Arg?Ala?Gly?Phe?Lys?Lys?Gly?His?Pro?Gly

295 300 305

gca?ggc?gca?aaa?gcc?tcc?ctg?agc?acc?aaa?cac?acc?ctc?gca?ctc?acc 1075

Ala?Gly?Ala?Lys?Ala?Ser?Leu?Ser?Thr?Lys?His?Thr?Leu?Ala?Leu?Thr

310 315 320 325

aac?cgt?ggc?gac?gcc?cgc?gcc?tcc?gac?ctc?gtc?gca?tta?gcc?aaa?gaa 1123

Asn?Arg?Gly?Asp?Ala?Arg?Ala?Ser?Asp?Leu?Val?Ala?Leu?Ala?Lys?Glu

330 335 340

atc?cgc?gac?gga?gtc?ctc?gaa?acc?ttc?ggc?gtc?acc?ctc?gtc?cca?gaa 1171

Ile?Arg?Asp?Gly?Val?Leu?Glu?Thr?Phe?Gly?Val?Thr?Leu?Val?Pro?Glu

345 350 355

ccc?gtc?tgg?att?gga?atc?agc?atc?gat?gac?tgaattttcc?gacgtccctg 1221

Pro?Val?Trp?Ile?Gly?Ile?Ser?Ile?Asp?Asp

360 365

gca 1224

<210>264

<211>367

<212>PRT

＜213〉Corynebacterium glutamicum

<400>264

Leu?Asp?Ser?Ser?Leu?Ala?Gln?Glu?Ile?Ala?Ala?Ile?Asp?Gly?Val?Glu

1 5 10 15

Leu?Asp?Ser?Glu?Val?Thr?Phe?Ala?Asp?Leu?Thr?Thr?Leu?Arg?Ile?Gly

20 25 30

Gly?Lys?Pro?Arg?Ser?Ala?Val?Arg?Cys?Gln?Thr?Thr?Glu?Ala?Leu?Val

35 40 45

Ser?Ala?Ile?Lys?Leu?Leu?Asp?Asp?Ala?Ser?Leu?Pro?Leu?Leu?Ile?Val

50 55 60

Gly?Gly?Gly?Ser?Asn?Leu?Val?Val?Ala?Asp?Gly?Asp?Leu?Asp?Val?Ile

65 70 75 80

Ala?Val?Ile?Ile?Glu?Thr?Asp?Asp?Val?Ser?Ile?Asn?Leu?Thr?Asp?Gly

85 90 95

Leu?Leu?Thr?Ala?Asp?Ala?Gly?Ala?Val?Trp?Asp?Asp?Val?Val?His?Leu

100 105 110

Ser?Val?Asp?Ala?Gly?Leu?Gly?Gly?Ile?Glu?Cys?Leu?Ser?Gly?Ile?Pro

115 120 125

Gly?Ser?Ala?Gly?Ala?Thr?Pro?Val?Gln?Asn?Val?Gly?Ala?Tyr?Gly?Thr

130 135 140

Glu?Val?Ser?Asp?Val?Leu?Thr?Arg?Val?Gln?Leu?Leu?Asp?Arg?Thr?Thr

145 150 155 160

His?Gln?Val?Ser?Trp?Val?Asp?Ala?Ser?Glu?Leu?Asp?Leu?Ser?Tyr?Arg

165 170 175

Tyr?Ser?Asn?Leu?Lys?Phe?Thr?Asn?Arg?Ala?Val?Val?Leu?Ala?Ile?Glu

180 185 190

Leu?Gln?Leu?Leu?Thr?Asp?Gly?Leu?Ser?Ala?Pro?Leu?Arg?Phe?Gly?Glu

195 200 205

Leu?Gly?Arg?Arg?Leu?Ala?Ile?Ser?Glu?Ala?Glu?Pro?His?Pro?Arg?Arg

210 215 220

Pro?Val?Arg?Met?Val?Arg?Asp?Ala?Val?Leu?Glu?Leu?Arg?Arg?Ala?Lys

225 230 235 240

Gly?Met?Val?Val?Glu?His?Thr?Asp?His?Asp?Thr?Trp?Ser?Ala?Gly?Ser

245 250 255

Phe?Phe?Thr?Asn?Pro?Ile?Val?Asp?Pro?Ala?Leu?Ala?Asp?Ala?Val?Phe

260 265 270

Glu?Lys?Val?Gly?Glu?Pro?Thr?Met?Pro?Arg?Phe?Pro?Ala?Gly?Asp?Gly

275 280 285

Lys?Glu?Lys?Leu?Ser?Ala?Ala?Trp?Leu?Ile?Glu?Arg?Ala?Gly?Phe?Lys

290 295 300

Lys?Gly?His?Pro?Gly?Ala?Gly?Ala?Lys?Ala?Ser?Leu?Ser?Thr?Lys?His

305 310 315 320

Thr?Leu?Ala?Leu?Thr?Asn?Arg?Gly?Asp?Ala?Arg?Ala?Ser?Asp?Leu?Val

325 330 335

Ala?Leu?Ala?Lys?Glu?Ile?Arg?Asp?Gly?Val?Leu?Glu?Thr?Phe?Gly?Val

340 345 350

Thr?Leu?Val?Pro?Glu?Pro?Val?Trp?Ile?Gly?Ile?Ser?Ile?Asp?Asp

355 360 365

<210>265

<211>1124

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(1101)

<223>RXA01216

<400>265

acc?gac?cac?act?ctg?tct?gca?ctg?ctg?gat?gca?cac?gtg?gaa?gtt?cca 48

Thr?Asp?His?Thr?Leu?Ser?Ala?Leu?Leu?Asp?Ala?His?Val?Glu?Val?Pro

1 5 10 15

acc?gct?gtc?acc?gtg?ttg?acc?atg?cgt?ctg?gat?gac?ccc?acc?ggc?tac 96

Thr?Ala?Val?Thr?Val?Leu?Thr?Met?Arg?Leu?Asp?Asp?Pro?Thr?Gly?Tyr

20 25 30

ggc?cgc?atc?gtg?cgc?aac?gaa?gaa?ggc?gaa?gtc?acc?gcc?atc?gtt?gag 144

Gly?Arg?Ile?Val?Arg?Asn?Glu?Glu?Gly?Glu?Val?Thr?Ala?Ile?Val?Glu

35 40 45

caa?aaa?gat?gct?tca?gca?gaa?gtc?caa?gcc?atc?gat?gag?gtc?aac?tcc 192

Gln?Lys?Asp?Ala?Ser?Ala?Glu?Val?Gln?Ala?Ile?Asp?Glu?Val?Asn?Ser

50 55 60

ggt?gtc?ttt?gct?ttc?gac?gcc?gcc?atc?ttg?cgt?tcc?gca?ctg?gct?gaa 240

Gly?Val?Phe?Ala?Phe?Asp?Ala?Ala?Ile?Leu?Arg?Ser?Ala?Leu?Ala?Glu

65 70 75 80

ctg?aag?tcc?gac?aac?gct?cag?ggc?gag?ctg?tac?ctg?acc?gac?gtt?ttg 288

Leu?Lys?Ser?Asp?Asn?Ala?Gln?Gly?Glu?Leu?Tyr?Leu?Thr?Asp?Val?Leu

85 90 95

ggc?att?gct?cgt?ggc?gag?ggc?cac?cca?gtg?cgc?gcc?cac?acc?gcc?gcc 336

Gly?Ile?Ala?Arg?Gly?Glu?Gly?His?Pro?Val?Arg?Ala?His?Thr?Ala?Ala

100 105 110

gat?gct?cgt?gaa?ctc?gcc?ggc?gtc?aac?gat?cgt?gtg?cag?ctc?gca?gaa 384

Asp?Ala?Arg?Glu?Leu?Ala?Gly?Val?Asn?Asp?Arg?Val?Gln?Leu?Ala?Glu

115 120 125

gcc?ggc?gcc?gaa?cta?aac?cgt?cgc?acc?gtc?atc?gcc?gct?atg?cgt?ggt 432

Ala?Gly?Ala?Glu?Leu?Asn?Arg?Arg?Thr?Val?Ile?Ala?Ala?Met?Arg?Gly

130 135 140

ggc?gca?acc?atc?gtt?gat?cca?gca?acc?acc?tgg?atc?gat?gtg?gag?gtt 480

Gly?Ala?Thr?Ile?Val?Asp?Pro?Ala?Thr?Thr?Trp?Ile?Asp?Val?Glu?Val

145 150 155 160

tct?atc?gga?cgc?gac?gtg?atc?atc?cac?cct?ggc?acc?cag?ctc?aag?ggc 528

Ser?Ile?Gly?Arg?Asp?Val?Ile?Ile?His?Pro?Gly?Thr?Gln?Leu?Lys?Gly

165 170 175

gaa?act?gtc?atc?gga?gac?cgc?gtt?gaa?gtt?ggt?cca?gac?acc?acc?ttg 576

Glu?Thr?Val?Ile?Gly?Asp?Arg?Val?Glu?Val?Gly?Pro?Asp?Thr?Thr?Leu

180 185 190

acc?aac?atg?acc?atc?ggc?gac?ggc?gca?tcc?gta?atc?cgc?acc?cac?ggt 624

Thr?Asn?Met?Thr?Ile?Gly?Asp?Gly?Ala?Ser?Val?Ile?Arg?Thr?His?Gly

195 200 205

ttc?gac?tcc?acc?atc?ggt?gaa?aac?gcc?acc?gtt?ggc?ccc?ttc?acc?tac 672

Phe?Asp?Ser?Thr?Ile?Gly?Glu?Asn?Ala?Thr?Val?Gly?Pro?Phe?Thr?Tyr

210 215 220

atc?cgc?cca?gga?acc?aca?ctg?gga?cca?gaa?ggc?aag?ctc?ggt?ggc?ttc 720

Ile?Arg?Pro?Gly?Thr?Thr?Leu?Gly?Pro?Glu?Gly?Lys?Leu?Gly?Gly?Phe

225 230 235 240

gta?gaa?acc?aag?aag?gcc?aca?atc?ggc?cgt?ggc?tcc?aag?gtt?cca?cac 768

Val?Glu?Thr?Lys?Lys?Ala?Thr?Ile?Gly?Arg?Gly?Ser?Lys?Val?Pro?His

245 250 255

ctc?acc?tat?gtc?ggc?gac?gcc?acc?atc?ggc?gag?gaa?tcc?aac?atc?gga 816

Leu?Thr?Tyr?Val?Gly?Asp?Ala?Thr?Ile?Gly?Glu?Glu?Ser?Asn?Ile?Gly

260 265 270

gcc?tcc?tct?gtc?ttc?gtg?aac?tac?gac?ggt?gaa?aac?aag?cac?cac?acc 864

Ala?Ser?Ser?Val?Phe?Val?Asn?Tyr?Asp?Gly?Glu?Asn?Lys?His?His?Thr

275 280 285

acc?atc?ggc?agc?cac?gtt?cgc?act?ggt?tct?gac?acc?atg?ttt?atc?gct 912

Thr?Ile?Gly?Ser?His?Val?Arg?Thr?Gly?Ser?Asp?Thr?Met?Phe?Ile?Ala

290 295 300

cca?gtg?acc?gtg?ggt?gac?gga?gcg?tat?tcc?gga?gcc?ggt?aca?gta?att 960

Pro?Val?Thr?Val?Gly?Asp?Gly?Ala?Tyr?Ser?Gly?Ala?Gly?Thr?Val?Ile

305 310 315 320

aaa?gac?gat?gtt?ccg?cca?gga?gcc?ctt?gcc?gtg?tcc?ggc?gga?cgc?caa 1008

Lys?Asp?Asp?Val?Pro?Pro?Gly?Ala?Leu?Ala?Val?Ser?Gly?Gly?Arg?Gln

325 330 335

cga?aac?atc?gaa?ggc?tgg?gtg?caa?aag?aag?cgc?cct?gga?acc?gct?gca 1056

Arg?Asn?Ile?Glu?Gly?Trp?Val?Gln?Lys?Lys?Arg?Pro?Gly?Thr?Ala?Ala

340 345 350

gca?caa?gcc?gca?gaa?gcc?gcc?caa?aac?gtc?cac?aac?cag?gaa?ggc 1101

Ala?Gln?Ala?Ala?Glu?Ala?Ala?Gln?Asn?Val?His?Asn?Gln?Glu?Gly

355 360 365

taagcaggat?cctcatgact?gct 1124

<210>266

<211>367

<212>PRT

＜213〉Corynebacterium glutamicum

<400>266

Thr?Asp?His?Thr?Leu?Ser?Ala?Leu?Leu?Asp?Ala?His?Val?Glu?Val?Pro

1 5 10 15

Thr?Ala?Val?Thr?Val?Leu?Thr?Met?Arg?Leu?Asp?Asp?Pro?Thr?Gly?Tyr

20 25 30

Gly?Arg?Ile?Val?Arg?Asn?Glu?Glu?Gly?Glu?Val?Thr?Ala?Ile?Val?Glu

35 40 45

Gln?Lys?Asp?Ala?Ser?Ala?Glu?Val?Gln?Ala?Ile?Asp?Glu?Val?Asn?Ser

50 55 60

Gly?Val?Phe?Ala?Phe?Asp?Ala?Ala?Ile?Leu?Arg?Ser?Ala?Leu?Ala?Glu

65 70 75 80

Leu?Lys?Ser?Asp?Asn?Ala?Gln?Gly?Glu?Leu?Tyr?Leu?Thr?Asp?Val?Leu

85 90 95

Gly?Ile?Ala?Arg?Gly?Glu?Gly?His?Pro?Val?Arg?Ala?His?Thr?Ala?Ala

100 105 110

Asp?Ala?Arg?Glu?Leu?Ala?Gly?Val?Asn?Asp?Arg?Val?Gln?Leu?Ala?Glu

115 120 125

Ala?Gly?Ala?Glu?Leu?Asn?Arg?Arg?Thr?Val?Ile?Ala?Ala?Met?Arg?Gly

130 135 140

Gly?Ala?Thr?Ile?Val?Asp?Pro?Ala?Thr?Thr?Trp?Ile?Asp?Val?Glu?Val

145 150 155 160

Ser?Ile?Gly?Arg?Asp?Val?Ile?Ile?His?Pro?Gly?Thr?Gln?Leu?Lys?Gly

165 170 175

Glu?Thr?Val?Ile?Gly?Asp?Arg?Val?Glu?Val?Gly?Pro?Asp?Thr?Thr?Leu

180 185 190

Thr?Asn?Met?Thr?Ile?Gly?Asp?Gly?Ala?Ser?Val?Ile?Arg?Thr?His?Gly

195 200 205

Phe?Asp?Ser?Thr?Ile?Gly?Glu?Asn?Ala?Thr?Val?Gly?Pro?Phe?Thr?Tyr

210 215 220

Ile?Arg?Pro?Gly?Thr?Thr?Leu?Gly?Pro?Glu?Gly?Lys?Leu?Gly?Gly?Phe

225 230 235 240

Val?Glu?Thr?Lys?Lys?Ala?Thr?Ile?Gly?Arg?Gly?Ser?Lys?Val?Pro?His

245 250 255

Leu?Thr?Tyr?Val?Gly?Asp?Ala?Thr?Ile?Gly?Glu?Glu?Ser?Asn?Ile?Gly

260 265 270

Ala?Ser?Ser?Val?Phe?Val?Asn?Tyr?Asp?Gly?Glu?Asn?Lys?His?His?Thr

275 280 285

Thr?lle?Gly?Ser?His?Val?Arg?Thr?Gly?Ser?Asp?Thr?Met?Phe?Ile?Ala

290 295 300

Pro?Val?Thr?Val?Gly?Asp?Gly?Ala?Tyr?Ser?Gly?Ala?Gly?Thr?Val?Ile

305 310 315 320

Lys?Asp?Asp?Val?Pro?Pro?Gly?Ala?Leu?Ala?Val?Ser?Gly?Gly?Arg?Gln

325 330 335

Arg?Asn?Ile?Glu?Gly?Trp?Val?Gln?Lys?Lys?Arg?Pro?Gly?Thr?Ala?Ala

340 345 350

Ala?Gln?Ala?Ala?Glu?Ala?Ala?Gln?Asn?Val?His?Asn?Gln?Glu?Gly

355 360 365

<210>267

<211>981

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(958)

<223>RXA01259

<400>267

aagagaatta?tttctaaaat?tcggtatcgt?ctaagaaatg?agtttgccaa?tagctcagca?60

tcaaaatgct?gtaaaaactg?tcgtggtacc?agctgcagga?atg?gga?aca?cgg?ttc 115

Met?Gly?Thr?Arg?Phe

1 5

ctt?cct?gca?acg?aag?aca?att?cca?aag?gag?ctt?ctt?cct?gta?gtt?gat 163

Leu?Pro?Ala?Thr?Lys?Thr?Ile?Pro?Lys?Glu?Leu?Leu?Pro?Val?Val?Asp

10 15 20

acc?ccg?ggt?att?gaa?ctt?gtt?gcc?aaa?gag?gct?gct?gat?ctt?ggt?gca 211

Thr?Pro?Gly?Ile?Glu?Leu?Val?Ala?Lys?Glu?Ala?Ala?Asp?Leu?Gly?Ala

25 30 35

act?cgg?tta?gca?att?atc?act?gct?ccg?aac?aaa?gac?gga?att?ctt?aaa 259

Thr?Arg?Leu?Ala?Ile?Ile?Thr?Ala?Pro?Asn?Lys?Asp?Gly?Ile?Leu?Lys

40 45 50

cac?ttc?gag?gag?ttc?cct?gag?ctt?gag?gca?act?ctt?gag?gct?cgc?ggt 307

His?Phe?Glu?Glu?Phe?Pro?Glu?Leu?Glu?Ala?Thr?Leu?Glu?Ala?Arg?Gly

55 60 65

aag?act?gat?caa?ctg?aat?aaa?gtt?cga?gca?gct?cga?gaa?ttg?att?gca 355

Lys?Thr?Asp?Gln?Leu?Asn?Lys?Val?Arg?Ala?Ala?Arg?Glu?Leu?Ile?Ala

70 75 80 85

aca?gtt?cca?gtg?gtt?caa?gaa?aag?cca?ttg?ggg?ctt?ggt?cac?gct?gtt 403

Thr?Val?Pro?Val?Val?Gln?Glu?Lys?Pro?Leu?Gly?Leu?Gly?His?Ala?Val

90 95 100

ggc?ctt?gct?gag?tct?gtg?ctc?gat?gat?gat?gaa?gat?gtt?gtg?gct?gtc 451

Gly?Leu?Ala?Glu?Ser?Val?Leu?Asp?Asp?Asp?Glu?Asp?Val?Val?Ala?Val

105 110 115

atg?ctg?cca?gac?gat?ttg?gtg?ctg?cca?ttt?ggt?gtg?acc?gag?aga?atg 499

Met?Leu?Pro?Asp?Asp?Leu?Val?Leu?Pro?Phe?Gly?Val?Thr?Glu?Arg?Met

120 125 130

gca?gaa?gtt?cgc?gct?aag?ttt?ggc?gga?tct?gtt?ctt?gca?gca?att?gag 547

Ala?Glu?Val?Arg?Ala?Lys?Phe?Gly?Gly?Ser?Val?Leu?Ala?Ala?Ile?Glu

135 140 145

gtg?gct?gaa?gat?gaa?gtc?tca?aat?tac?gga?gta?ttt?aag?ctc?ggt?gaa 595

Val?Ala?Glu?Asp?Glu?Val?Ser?Asn?Tyr?Gly?Val?Phe?Lys?Leu?Gly?Glu

150 155 160 165

ctc?gat?gca?gag?tcc?gaa?agt?gaa?ggc?att?agg?cgt?gtt?gta?gga?atg 643

Leu?Asp?Ala?Glu?Ser?Glu?Ser?Glu?Gly?Ile?Arg?Arg?Val?Val?Gly?Met

170 175 180

gtt?gaa?aag?cct?gcg?cct?gaa?gat?gca?cca?tca?agg?ttt?gcc?gca?acg 691

Val?Glu?Lys?Pro?Ala?Pro?Glu?Asp?Ala?Pro?Ser?Arg?Phe?Ala?Ala?Thr

185 190 195

ggc?cgt?tat?cta?ctt?gat?cga?gct?att?ttt?gat?gca?ctg?cgt?cga?att 739

Gly?Arg?Tyr?Leu?Leu?Asp?Arg?Ala?Ile?Phe?Asp?Ala?Leu?Arg?Arg?Ile

200 205 210

gag?cct?ggt?gct?ggt?gga?gaa?ctg?caa?tta?aca?gat?gcc?atc?gca?tta 787

Glu?Pro?Gly?Ala?Gly?Gly?Glu?Leu?Gln?Leu?Thr?Asp?Ala?Ile?Ala?Leu

215 220 225

ttg?atc?gaa?gaa?ggc?cat?ccg?gta?cac?att?gtg?gtt?cat?gaa?gga?aag 835

Leu?Ile?Glu?Glu?Gly?His?Pro?Val?His?Ile?Val?Val?His?Glu?Gly?Lys

230 235 240 245

cgc?cat?gac?ctt?ggt?aat?cca?gct?ggg?tac?att?cct?gct?gtt?gtg?tac 883

Arg?His?Asp?Leu?Gly?Asn?Pro?Ala?Gly?Tyr?Ile?Pro?Ala?Val?Val?Tyr

250 255 260

ttc?gga?ctt?cgt?cat?gca?gag?tac?ggt?tcc?aag?att?cac?cgt?gcg?gtg 931

Phe?Gly?Leu?Arg?His?Ala?Glu?Tyr?Gly?Ser?Lys?Ile?His?Arg?Ala?Val

265 270 275

aag?gaa?ata?ctc?gct?gag?ttt?gaa?tct?taaaaaggaa?accgccttcc 978

Lys?Glu?Ile?Leu?Ala?Glu?Phe?Glu?Ser

280 285

aca 981

<210>268

<211>286

<212>PRT

＜213〉Corynebacterium glutamicum

<400>268

Met?Gly?Thr?Arg?Phe?Leu?Pro?Ala?Thr?Lys?Thr?Ile?Pro?Lys?Glu?Leu

1 5 10 15

Leu?Pro?Val?Val?Asp?Thr?Pro?Gly?Ile?Glu?Leu?Val?Ala?Lys?Glu?Ala

20 25 30

Ala?Asp?Leu?Gly?Ala?Thr?Arg?Leu?Ala?Ile?Ile?Thr?Ala?Pro?Asn?Lys

35 40 45

Asp?Gly?Ile?Leu?Lys?His?Phe?Glu?Glu?Phe?Pro?Glu?Leu?Glu?Ala?Thr

50 55 60

Leu?Glu?Ala?Arg?Gly?Lys?Thr?Asp?Gln?Leu?Asn?Lys?Val?Arg?Ala?Ala

65 70 75 80

Arg?Glu?Leu?Ile?Ala?Thr?Val?Pro?Val?Val?Gln?Glu?Lys?Pro?Leu?Gly

85 90 95

Leu?Gly?His?Ala?Val?Gly?Leu?Ala?Glu?Ser?Val?Leu?Asp?Asp?Asp?Glu

100 105 110

Asp?Val?Val?Ala?Val?Met?Leu?Pro?Asp?Asp?Leu?Val?Leu?Pro?Phe?Gly

115 120 125

Val?Thr?Glu?Arg?Met?Ala?Glu?Val?Arg?Ala?Lys?Phe?Gly?Gly?Ser?Val

130 135 140

Leu?Ala?Ala?Ile?Glu?Val?Ala?Glu?Asp?Glu?Val?Ser?Asn?Tyr?Gly?Val

145 150 155 160

Phe?Lys?Leu?Gly?Glu?Leu?Asp?Ala?Glu?Ser?Glu?Ser?Glu?Gly?Ile?Arg

165 170 175

Arg?Val?Val?Gly?Met?Val?Glu?Lys?Pro?Ala?Pro?Glu?Asp?Ala?Pro?Ser

180 185 190

Arg?Phe?Ala?Ala?Thr?Gly?Arg?Tyr?Leu?Leu?Asp?Arg?Ala?Ile?Phe?Asp

195 200 205

Ala?Leu?Arg?Arg?Ile?Glu?Pro?Gly?Ala?Gly?Gly?Glu?Leu?Gln?Leu?Thr

210 215 220

Asp?Ala?Ile?Ala?Leu?Leu?Ile?Glu?Glu?Gly?His?Pro?Val?His?Ile?Val

225 230 235 240

Val?His?Glu?Gly?Lys?Arg?His?Asp?Leu?Gly?Asn?Pro?Ala?Gly?Tyr?Ile

245 250 255

Pro?Ala?Val?Val?Tyr?Phe?Gly?Leu?Arg?His?Ala?Glu?Tyr?Gly?Ser?Lys

260 265 270

Ile?His?Arg?Ala?Val?Lys?Glu?Ile?Leu?Ala?Glu?Phe?Glu?Ser

275 280 285

<210>269

<211>526

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(526)

<223>RXA02028

<400>269

tgcgcagttc?ctgcttagtt?tggctcataa?atctaaggat?aaccgttatt?ttcggagggg?60

tacgacgatt?ggggttgcgg?gggcaggtac?tcttggttcc?atg?agt?ttg?cct?atc 115

Met?Ser?Leu?Pro?Ile

1 5

gat?gag?cac?gtg?aac?gcg?gtt?aaa?acc?gtc?gta?gtg?cct?gct?gca?gga 163

Asp?Glu?His?Val?Asn?Ala?Val?Lys?Thr?Val?Val?Val?Pro?Ala?Ala?Gly

10 15 20

ctg?gga?acc?cga?ttc?ctt?ccg?gcc?acc?aaa?acc?gta?ccc?aag?gag?ttg 211

Leu?Gly?Thr?Arg?Phe?Leu?Pro?Ala?Thr?Lys?Thr?Val?Pro?Lys?Glu?Leu

25 30 35

ctg?ccg?gtt?gtc?gat?acc?cca?ggt?att?gag?ctg?att?gct?gct?gag?gct 259

Leu?Pro?Val?Val?Asp?Thr?Pro?Gly?Ile?Glu?Leu?Ile?Ala?Ala?Glu?Ala

40 45 50

gcc?gaa?ctt?ggt?gcg?acc?agg?ctg?gcg?atc?atc?act?gcg?cca?aac?aaa 307

Ala?Glu?Leu?Gly?Ala?Thr?Arg?Leu?Ala?Ile?Ile?Thr?Ala?Pro?Asn?Lys

55 60 65

gct?ggg?gta?ctt?gca?cac?ttt?gag?cgt?tct?tct?gaa?ttg?gaa?gaa?acg 355

Ala?Gly?Val?Leu?Ala?His?Phe?Glu?Arg?Ser?Ser?Glu?Leu?Glu?Glu?Thr

70 75 80 85

ctg?atg?gag?cgt?ggc?aag?act?gac?cag?gtg?gag?ata?atc?cgc?cgc?gcc 403

Leu?Met?Glu?Arg?Gly?Lys?Thr?Asp?Gln?Val?Glu?Ile?Ile?Arg?Arg?Ala

90 95 100

gcc?gat?tta?atc?aag?gca?gtt?cca?gta?acc?cag?gac?aag?ccg?ctg?ggg 451

Ala?Asp?Leu?Ile?Lys?Ala?Val?Pro?Val?Thr?Gln?Asp?Lys?Pro?Leu?Gly

105 110 115

cta?ggt?cat?gct?gtt?ggt?ttg?gct?gag?tct?gtg?ttg?gat?gat?gat?gaa 499

Leu?Gly?His?Ala?Val?Gly?Leu?Ala?Glu?Ser?Val?Leu?Asp?Asp?Asp?Glu

120 125 130

gat?gtc?gta?gcg?gtg?atg?ttg?ccg?cac 526

Asp?Val?Val?Ala?Val?Met?Leu?Pro?His

135 140

<210>270

<211>142

<212>PRT

＜213〉Corynebacterium glutamicum

<400>270

Met?Ser?Leu?Pro?Ile?Asp?Glu?His?Val?Asn?Ala?Val?Lys?Thr?Val?Val

1 5 10 15

Val?Pro?Ala?Ala?Gly?Leu?Gly?Thr?Arg?Phe?Leu?Pro?Ala?Thr?Lys?Thr

20 25 30

Val?Pro?Lys?Glu?Leu?Leu?Pro?Val?Val?Asp?Thr?Pro?Gly?Ile?Glu?Leu

35 40 45

Ile?Ala?Ala?Glu?Ala?Ala?Glu?Leu?Gly?Ala?Thr?Arg?Leu?Ala?Ile?Ile

50 55 60

Thr?Ala?Pro?Asn?Lys?Ala?Gly?Val?Leu?Ala?His?Phe?Glu?Arg?Ser?Ser

65 70 75 80

Glu?Leu?Glu?Glu?Thr?Leu?Met?Glu?Arg?Gly?Lys?Thr?Asp?Gln?Val?Glu

85 90 95

Ile?Ile?Arg?Arg?Ala?Ala?Asp?Leu?Ile?Lys?Ala?Val?Pro?Val?Thr?Gln

100 105 110

Asp?Lys?Pro?Leu?Gly?Leu?Gly?His?Ala?Val?Gly?Leu?Ala?Glu?Ser?Val

115 120 125

Leu?Asp?Asp?Asp?Glu?Asp?Val?Val?Ala?Val?Met?Leu?Pro?His

130 135 140

<210>271

<211>1284

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1261)

<223>RXA01262

<400>271

tatactcgtc?aagggccttc?gataaaacaa?agacaatttt?cccccgacgg?gacaatctga?60

aaacttgctg?tatcaataaa?acacgaaaag?gaatactttt?atg?aaa?att?gcc?gtc 115

Met?Lys?Ile?Ala?Val

1 5

gca?ggg?ctc?gga?tat?gtt?ggg?ctt?tca?aat?gca?gct?ctc?ctc?tct?aaa 163

Ala?Gly?Leu?Gly?Tyr?Val?Gly?Leu?Ser?Asn?Ala?Ala?Leu?Leu?Ser?Lys

10 15 20

aat?cat?aaa?gtt?gtt?gca?gtt?gac?att?gat?gaa?gaa?cga?gtg?aaa?cta 211

Asn?His?Lys?Val?Val?Ala?Val?Asp?Ile?Asp?Glu?Glu?Arg?Val?Lys?Leu

25 30 35

gtt?caa?gaa?ttt?cgt?tcg?cca?att?gtc?gat?agc?gat?ctc?gaa?gaa?tat 259

Val?Gln?Glu?Phe?Arg?Ser?Pro?Ile?Val?Asp?Ser?Asp?Leu?Glu?Glu?Tyr

40 45 50

ctg?tcc?act?aag?cct?caa?aac?tta?act?gcc?aca?acg?gac?gcc?gaa?gcc 307

Leu?Ser?Thr?Lys?Pro?Gln?Asn?Leu?Thr?Ala?Thr?Thr?Asp?Ala?Glu?Ala

55 60 65

gct?tac?aaa?ggc?gca?gat?ttt?att?gtt?att?gca?acg?cca?act?aat?tac 355

Ala?Tyr?Lys?Gly?Ala?Asp?Phe?Ile?Val?Ile?Ala?Thr?Pro?Thr?Asn?Tyr

70 75 80 85

gac?cca?gag?tca?aac?ttt?ttt?gat?act?tcc?agc?gtt?gag?tcc?gta?att 403

Asp?Pro?Glu?Ser?Asn?Phe?Phe?Asp?Thr?Ser?Ser?Val?Glu?Ser?Val?Ile

90 95 100

gag?ata?gtc?ctt?aag?gtt?tct?cct?gga?tcc?aca?atc?gta?att?aaa?tcg 451

Glu?Ile?Val?Leu?Lys?Val?Ser?Pro?Gly?Ser?Thr?Ile?Val?Ile?Lys?Ser

105 110 115

act?atc?cct?gtt?ggt?ttt?aca?tcg?gaa?cta?cgc?att?aag?cat?cca?gaa 499

Thr?Ile?Pro?Val?Gly?Phe?Thr?Ser?Glu?Leu?Arg?Ile?Lys?His?Pro?Glu

120 125 130

gct?tcg?att?att?ttt?tca?cct?gag?ttc?ctg?cgt?gaa?ggc?cga?gca?ttc 547

Ala?Ser?Ile?Ile?Phe?Ser?Pro?Glu?Phe?Leu?Arg?Glu?Gly?Arg?Ala?Phe

135 140 145

tac?gac?aat?ctc?tac?cca?tcc?aga?gtt?gtc?gtt?ggt?gat?cgc?agt?cct 595

Tyr?Asp?Asn?Leu?Tyr?Pro?Ser?Arg?Val?Val?Val?Gly?Asp?Arg?Ser?Pro

150 155 160 165

ctg?ggg?gaa?gaa?ttt?gcg?act?ctg?tta?gct?gag?ggg?gca?aaa?gaa?aag 643

Leu?Gly?Glu?Glu?Phe?Ala?Thr?Leu?Leu?Ala?Glu?Gly?Ala?Lys?Glu?Lys

170 175 180

cct?ccg?att?cta?ctt?acg?gac?tca?act?gag?gca?gag?gcg?att?aaa?tta 691

Pro?Pro?Ile?Leu?Leu?Thr?Asp?Ser?Thr?Glu?Ala?Glu?Ala?Ile?Lys?Leu

185 190 195

ttt?tct?aat?aca?tat?ctt?gca?ctg?cga?gtt?gct?ttt?ttc?aac?gaa?ctg 739

Phe?Ser?Asn?Thr?Tyr?Leu?Ala?Leu?Arg?Val?Ala?Phe?Phe?Asn?Glu?Leu

200 205 210

gat?act?tat?gcg?tct?gtt?cga?agc?ttg?gat?act?aag?cag?att?att?gaa 787

Asp?Thr?Tyr?Ala?Ser?Val?Arg?Ser?Leu?Asp?Thr?Lys?Gln?Ile?Ile?Glu

215 220 225

ggg?gta?ggg?ctc?gat?cca?cgt?att?gga?tct?cat?tac?aat?aat?cct?tca 835

Gly?Val?Gly?Leu?Asp?Pro?Arg?Ile?Gly?Ser?His?Tyr?Asn?Asn?Pro?Ser

230 235 240 245

ttt?gga?tat?ggc?gga?tat?tgt?ctt?ccg?aaa?gat?acg?aaa?cag?ctt?ctc 883

Phe?Gly?Tyr?Gly?Gly?Tyr?Cys?Leu?Pro?Lys?Asp?Thr?Lys?Gln?Leu?Leu

250 255 260

gcc?aac?tat?aag?gat?gtc?ccg?cag?aat?cta?atc?tct?gca?gta?gtc?caa 931

Ala?Asn?Tyr?Lys?Asp?Val?Pro?Gln?Asn?Leu?Ile?Ser?Ala?Val?Val?Gln

265 270 275

gca?aat?aag?act?cgt?aag?gac?ttt?att?gca?gag?gat?atc?ctc?agt?aaa 979

Ala?Asn?Lys?Thr?Arg?Lys?Asp?Phe?Ile?Ala?Glu?Asp?Ile?Leu?Ser?Lys

280 285 290

tca?cct?act?gta?gtt?gga?att?tac?cgc?ctt?gta?atg?aag?tct?gga?tca 1027

Ser?Pro?Thr?Val?Val?Gly?Ile?Tyr?Arg?Leu?Val?Met?Lys?Ser?Gly?Ser

295 300 305

gat?aac?ttt?cgt?tct?tct?tct?att?caa?gga?gtc?atg?aaa?cga?att?aag 1075

Asp?Asn?Phe?Arg?Ser?Ser?Ser?Ile?Gln?Gly?Val?Met?Lys?Arg?Ile?Lys

310 315 320 325

gcc?aag?gga?atc?gaa?att?gta?gta?ttt?gaa?ccg?aat?ctc?gga?gaa?gaa 1123

Ala?Lys?Gly?Ile?Glu?Ile?Val?Val?Phe?Glu?Pro?Asn?Leu?Gly?Glu?Glu

330 335 340

act?ttc?tac?aat?tcg?aag?atc?ctt?aat?gac?atc?gaa?gag?ttt?aag?gat 1171

Thr?Phe?Tyr?Asn?Ser?Lys?Ile?Leu?Asn?Asp?Ile?Glu?Glu?Phe?Lys?Asp

345 350 355

tac?tgc?gac?atc?att?att?gca?aat?cgt?cca?acc?gat?gag?ctt?tct?gat 1219

Tyr?Cys?Asp?Ile?Ile?Ile?Ala?Asn?Arg?Pro?Thr?Asp?Glu?Leu?Ser?Asp

360 365 370

gta?cca?gaa?aaa?gtt?tat?aca?cgt?gat?att?ttc?cag?cgt?gac 1261

Val?Pro?Glu?Lys?Val?Tyr?Thr?Arg?Asp?Ile?Phe?Gln?Arg?Asp

375 380 385

taagtggaaa?gaatcttttg?ttg 1284

<210>272

<211>387

<212>PRT

＜213〉Corynebacterium glutamicum

<400>272

Met?Lys?Ile?Ala?Val?Ala?Gly?Leu?Gly?Tyr?Val?Gly?Leu?Ser?Asn?Ala

1 5 10 15

Ala?Leu?Leu?Ser?Lys?Asn?His?Lys?Val?Val?Ala?Val?Asp?Ile?Asp?Glu

20 25 30

Glu?Arg?Val?Lys?Leu?Val?Gln?Glu?Phe?Arg?Ser?Pro?Ile?Val?Asp?Ser

35 40 45

Asp?Leu?Glu?Glu?Tyr?Leu?Ser?Thr?Lys?Pro?Gln?Asn?Leu?Thr?Ala?Thr

50 55 60

Thr?Asp?Ala?Glu?Ala?Ala?Tyr?Lys?Gly?Ala?Asp?Phe?Ile?Val?Ile?Ala

65 70 75 80

Thr?Pro?Thr?Asn?Tyr?Asp?Pro?Glu?Ser?Asn?Phe?Phe?Asp?Thr?Ser?Ser

85 90 95

Val?Glu?Ser?Val?Ile?Glu?Ile?Val?Leu?Lys?Val?Ser?Pro?Gly?Ser?Thr

100 105 110

Ile?Val?Ile?Lys?Ser?Thr?Ile?Pro?Val?Gly?Phe?Thr?Ser?Glu?Leu?Arg

115 120 125

Ile?Lys?His?Pro?Glu?Ala?Ser?Ile?Ile?Phe?Ser?Pro?Glu?Phe?Leu?Arg

130 135 140

Glu?Gly?Arg?Ala?Phe?Tyr?Asp?Asn?Leu?Tyr?Pro?Ser?Arg?Val?Val?Val

145 150 155 160

Gly?Asp?Arg?Ser?Pro?Leu?Gly?Glu?Glu?Phe?Ala?Thr?Leu?Leu?Ala?Glu

165 170 175

Gly?Ala?Lys?Glu?Lys?Pro?Pro?lle?Leu?Leu?Thr?Asp?Ser?Thr?Glu?Ala

180 185 190

Glu?Ala?Ile?Lys?Leu?Phe?Ser?Asn?Thr?Tyr?Leu?Ala?Leu?Arg?Val?Ala

195 200 205

Phe?Phe?Asn?Glu?Leu?Asp?Thr?Tyr?Ala?Ser?Val?Arg?Ser?Leu?Asp?Thr

210 215 220

Lys?Gln?Ile?Ile?Glu?Gly?Val?Gly?Leu?Asp?Pro?Arg?Ile?Gly?Ser?His

225 230 235 240

Tyr?Asn?Asn?Pro?Ser?Phe?Gly?Tyr?Gly?Gly?Tyr?Cys?Leu?Pro?Lys?Asp

245 250 255

Thr?Lys?Gln?Leu?Leu?Ala?Asn?Tyr?Lys?Asp?Val?Pro?Gln?Asn?Leu?Ile

260 265 270

Ser?Ala?Val?Val?Gln?Ala?Asn?Lys?Thr?Arg?Lys?Asp?Phe?Ile?Ala?Glu

275 280 285

Asp?Ile?Leu?Ser?Lys?Ser?Pro?Thr?Val?Val?Gly?Ile?Tyr?Arg?Leu?Val

290 295 300

Met?Lys?Ser?Gly?Ser?Asp?Asn?Phe?Arg?Ser?Ser?Ser?Ile?Gln?Gly?Val

305 310 315 320

Met?Lys?Arg?Ile?Lys?Ala?Lys?Gly?Ile?Glu?Ile?Val?Val?Phe?Glu?Pro

325 330 335

Asn?Leu?Gly?Glu?Glu?Thr?Phe?Tyr?Asn?Ser?Lys?Ile?Leu?Asn?Asp?Ile

340 345 350

Glu?Glu?Phe?Lys?Asp?Tyr?Cys?Asp?Ile?Ile?Ile?Ala?Asn?Arg?Pro?Thr

355 360 365

Asp?Glu?Leu?Ser?Asp?Val?Pro?Glu?Lys?Val?Tyr?Thr?Arg?Asp?Ile?Phe

370 375 380

Gln?Arg?Asp

385

<210>273

<211>1209

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1186)

<223>RXA01377

<400>273

tgaaatggat?ttgctgcggc?cccggaatta?cccttttcgc?ggccgtcatc?aaatttgtac?60

ccccttaaag?acaccctaaa?cacgagtgaa?ataggaacac?atg?act?tta?act?gac 115

Met?Thr?Leu?Thr?Asp

1 5

aac?agc?aaa?aac?gtt?gat?gct?gtc?atc?ttg?gtc?ggt?ggc?aaa?ggt?acc 163

Asn?Ser?Lys?Asn?Val?Asp?Ala?Val?Ile?Leu?Val?Gly?Gly?Lys?Gly?Thr

10 15 20

cga?ctg?cgc?ccc?ctg?acc?gtc?aat?act?cca?aag?cca?atg?ctg?cca?act 211

Arg?Leu?Arg?Pro?Leu?Thr?Val?Asn?Thr?Pro?Lys?Pro?Met?Leu?Pro?Thr

25 30 35

gct?ggc?cac?cca?ttc?ttg?acc?cac?ctt?ttg?gcc?cgc?atc?aag?gcc?gca 259

Ala?Gly?His?Pro?Phe?Leu?Thr?His?Leu?Leu?Ala?Arg?Ile?Lys?Ala?Ala

40 45 50

ggc?atc?aca?cac?gtc?gtg?ctg?gga?acg?tca?ttc?aaa?gct?gaa?gtc?ttc 307

Gly?Ile?Thr?His?Val?Val?Leu?Gly?Thr?Ser?Phe?Lys?Ala?Glu?Val?Phe

55 60 65

gag?gaa?tac?ttc?gga?gat?ggc?tcc?gaa?atg?ggc?ttg?gaa?att?gaa?tat 355

Glu?Glu?Tyr?Phe?Gly?Asp?Gly?Ser?Glu?Met?Gly?Leu?Glu?Ile?Glu?Tyr

70 75 80 85

gtc?gtc?gag?gat?cag?cct?ttg?ggc?act?ggt?ggt?ggc?atc?cga?aac?gtc 403

Val?Val?Glu?Asp?Gln?Pro?Leu?Gly?Thr?Gly?Gly?Gly?Ile?Arg?Asn?Val

90 95 100

tac?gac?aag?ctg?cgt?cac?gat?act?gcg?att?gtg?ttc?aac?ggc?gat?gtg 451

Tyr?Asp?Lys?Leu?Arg?His?Asp?Thr?Ala?Ile?Val?Phe?Asn?Gly?Asp?Val

105 110 115

ctc?tcc?ggt?gcg?gat?ctc?aac?agc?att?ctg?gac?acc?cac?cgc?gaa?aag 499

Leu?Ser?Gly?Ala?Asp?Leu?Asn?Ser?Ile?Leu?Asp?Thr?His?Arg?Glu?Lys

120 125 130

gac?gca?gat?ctg?acc?atg?cat?ctc?gtg?cgc?gta?gct?aac?cct?cgt?gcg 547

Asp?Ala?Asp?Leu?Thr?Met?His?Leu?Val?Arg?Val?Ala?Asn?Pro?Arg?Ala

135 140 145

ttt?ggt?tgc?gtc?ccc?acc?gat?gag?gat?ggt?cgc?gtc?agc?gaa?ttc?ctt 595

Phe?Gly?Cys?Val?Pro?Thr?Asp?Glu?Asp?Gly?Arg?Val?Ser?Glu?Phe?Leu

150 155 160 165

gaa?aag?acc?gaa?gat?cca?cca?acc?gat?cag?atc?aac?gcc?ggc?tgc?tac 643

Glu?Lys?Thr?Glu?Asp?Pro?Pro?Thr?Asp?Gln?Ile?Asn?Ala?Gly?Cys?Tyr

170 175 180

gtg?ttc?aag?aag?gaa?ctc?atc?gag?cag?atc?ccg?gca?ggc?cga?gca?gtt 691

Val?Phe?Lys?Lys?Glu?Leu?Ile?Glu?Gln?Ile?Pro?Ala?Gly?Arg?Ala?Val

185 190 195

tcc?gtc?gag?cgc?gaa?acc?ttc?cct?cag?ctg?ttg?gaa?gaa?ggc?aag?cga 739

Ser?Val?Glu?Arg?Glu?Thr?Phe?Pro?Gln?Leu?Leu?Glu?Glu?Gly?Lys?Arg

200 205 210

gtc?ttc?ggc?cac?gtc?gac?gct?tcc?tac?tgg?cgc?gac?atg?ggc?acc?cca 787

Val?Phe?Gly?His?Val?Asp?Ala?Ser?Tyr?Trp?Arg?Asp?Met?Gly?Thr?Pro

215 220 225

agc?gac?ttc?gtc?cgc?ggc?tcg?gct?gac?ctg?gtc?cgc?ggc?att?gcg?tac 835

Ser?Asp?Phe?Val?Arg?Gly?Ser?Ala?Asp?Leu?Val?Arg?Gly?Ile?Ala?Tyr

230 235 240 245

tcc?cca?ttg?ctc?gaa?ggc?aaa?aca?gga?gag?tcg?ctt?gtc?gac?gcc?tcc 883

Ser?Pro?Leu?Leu?Glu?Gly?Lys?Thr?Gly?Glu?Ser?Leu?Val?Asp?Ala?Ser

250 255 260

gcc?ggc?gtt?cgc?gac?ggc?gtc?ctg?ctg?ctc?ggc?gga?acc?gta?gtc?ggc 931

Ala?Gly?Val?Arg?Asp?Gly?Val?Leu?Leu?Leu?Gly?Gly?Thr?Val?Val?Gly

265 270 275

cgc?ggc?act?gag?atc?ggt?gcc?ggc?tgc?cgc?gtt?gac?aac?act?gtt?att 979

Arg?Gly?Thr?Glu?Ile?Gly?Ala?Gly?Cys?Arg?Val?Asp?Asn?Thr?Val?Ile

280 285 290

ttc?gac?ggc?gtc?acc?att?gaa?cca?ggt?gcg?gtc?att?gaa?aat?tcc?atc 1027

Phe?Asp?Gly?Val?Thr?Ile?Glu?Pro?Gly?Ala?Val?Ile?Glu?Asn?Ser?Ile

295 300 305

att?tcc?tcg?gga?gca?cgc?atc?ggt?gct?aat?gcg?cac?atc?tcc?ggt?tgc 1075

Ile?Ser?Ser?Gly?Ala?Arg?Ile?Gly?Ala?Asn?Ala?His?Ile?Ser?Gly?Cys

310 315 320 325

atc?att?ggc?gag?ggc?gca?cag?gtt?ggt?gct?cgg?tgt?gaa?ctc?aac?gca 1123

Ile?Ile?Gly?Glu?Gly?Ala?Gln?Val?Gly?Ala?Arg?Cys?Glu?Leu?Asn?Ala

330 335 340

ggg?atg?cgc?gtc?ttc?cca?ggc?gtt?gtg?atc?cca?gac?agc?gga?att?cgt 1171

Gly?Met?Arg?Val?Phe?Pro?Gly?Val?Val?Ile?Pro?Asp?Ser?Gly?Ile?Arg

345 350 355

ttt?tcg?tct?gat?cag?taggcatttt?tagccctttt?gga 1209

Phe?Ser?Ser?Asp?Gln

360

<210>274

<211>362

<212>PRT

＜213〉Corynebacterium glutamicum

<400>274

Met?Thr?Leu?Thr?Asp?Asn?Ser?Lys?Asn?Val?Asp?Ala?Val?Ile?Leu?Val

1 5 10 15

Gly?Gly?Lys?Gly?Thr?Arg?Leu?Arg?Pro?Leu?Thr?Val?Asn?Thr?Pro?Lys

20 25 30

Pro?Met?Leu?Pro?Thr?Ala?Gly?His?Pro?Phe?Leu?Thr?His?Leu?Leu?Ala

35 40 45

Arg?Ile?Lys?Ala?Ala?Gly?Ile?Thr?His?Val?Val?Leu?Gly?Thr?Ser?Phe

50 55 60

Lys?Ala?Glu?Val?Phe?Glu?Glu?Tyr?Phe?Gly?Asp?Gly?Ser?Glu?Met?Gly

65 70 75 80

Leu?Glu?Ile?Glu?Tyr?Val?Val?Glu?Asp?Gln?Pro?Leu?Gly?Thr?Gly?Gly

85 90 95

Gly?Ile?Arg?Asn?Val?Tyr?Asp?Lys?Leu?Arg?His?Asp?Thr?Ala?Ile?Val

100 105 110

Phe?Asn?Gly?Asp?Val?Leu?Ser?Gly?Ala?Asp?Leu?Asn?Ser?Ile?Leu?Asp

115 120 125

Thr?His?Arg?Glu?Lys?Asp?Ala?Asp?Leu?Thr?Met?His?Leu?Val?Arg?Val

130 135 140

Ala?Asn?Pro?Arg?Ala?Phe?Gly?Cys?Val?Pro?Thr?Asp?Glu?Asp?Gly?Arg

145 150 155 160

Val?Ser?Glu?Phe?Leu?Glu?Lys?Thr?Glu?Asp?Pro?Pro?Thr?Asp?Gln?Ile

165 170 175

Asn?Ala?Gly?Cys?Tyr?Val?Phe?Lys?Lys?Glu?Leu?Ile?Glu?Gln?Ile?Pro

180 185 190

Ala?Gly?Arg?Ala?Val?Ser?Val?Glu?Arg?Glu?Thr?Phe?Pro?Gln?Leu?Leu

195 200 205

Glu?Glu?Gly?Lys?Arg?Val?Phe?Gly?His?Val?Asp?Ala?Ser?Tyr?Trp?Arg

210 215 220

Asp?Met?Gly?Thr?Pro?Ser?Asp?Phe?Val?Arg?Gly?Ser?Ala?Asp?Leu?Val

225 230 235 240

Arg?Gly?Ile?Ala?Tyr?Ser?Pro?Leu?Leu?Glu?Gly?Lys?Thr?Gly?Glu?Ser

245 250 255

Leu?Val?Asp?Ala?Ser?Ala?Gly?Val?Arg?Asp?Gly?Val?Leu?Leu?Leu?Gly

260 265 270

Gly?Thr?Val?Val?Gly?Arg?Gly?Thr?Glu?Ile?Gly?Ala?Gly?Cys?Arg?Val

275 280 285

Asp?Asn?Thr?Val?Ile?Phe?Asp?Gly?Val?Thr?Ile?Glu?Pro?Gly?Ala?Val

290 295 300

Ile?Glu?Asn?Ser?Ile?Ile?Ser?Ser?Gly?Ala?Arg?Ile?Gly?Ala?Asn?Ala

305 310 315 320

His?Ile?Ser?Gly?Cys?Ile?Ile?Gly?Glu?Gly?Ala?Gln?Val?Gly?Ala?Arg

325 330 335

Cys?Glu?Leu?Asn?Ala?Gly?Met?Arg?Val?Phe?Pro?Gly?Val?Val?Ile?Pro

340 345 350

Asp?Ser?Gly?Ile?Arg?Phe?Ser?Ser?Asp?Gln

355 360

<210>275

<211>1350

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1327)

<223>RXA02063

<400>275

accgaaatgg?gggcattaaa?aggggctatc?attcggaccc?caaaacgatg?tttagacaat?60

ttgttaccca?gctttcatgc?gggatagtta?ttttgccttt?atg?gtt?aag?ggt?gtg 115

Met?Val?Lys?Gly?Val

1 5

aag?ggt?aga?cca?aat?gtt?cta?gca?atc?gtt?ctc?gca?ggt?ggc?gag?ggc 163

Lys?Gly?Arg?Pro?Asn?Val?Leu?Ala?Ile?Val?Leu?Ala?Gly?Gly?Glu?Gly

10 15 20

aaa?cga?ctt?ttt?ccg?ttg?acg?gag?gac?cga?gct?aag?cct?gcg?gtc?cca 211

Lys?Arg?Leu?Phe?Pro?Leu?Thr?Glu?Asp?Arg?Ala?Lys?Pro?Ala?Val?Pro

25 30 35

ttc?ggc?gga?act?tac?aga?ttg?atc?gac?ttt?gtt?ttg?tcg?aac?ctg?gtg 259

Phe?Gly?Gly?Thr?Tyr?Arg?Leu?Ile?Asp?Phe?Val?Leu?Ser?Asn?Leu?Val

40 45 50

aac?tcc?gga?ttc?ctc?aag?atc?gcg?gta?ctg?act?cag?tac?aag?tcg?cat 307

Asn?Ser?Gly?Phe?Leu?Lys?Ile?Ala?Val?Leu?Thr?Gln?Tyr?Lys?Ser?His

55 60 65

tca?ttg?gat?agg?cat?att?tca?ttg?tcg?tgg?aac?gtg?tct?ggt?cca?acg 355

Ser?Leu?Asp?Arg?His?Ile?Ser?Leu?Ser?Trp?Asn?Val?Ser?Gly?Pro?Thr

70 75 80 85

ggg?cag?tac?att?gct?tct?gtt?cct?gcg?cag?cag?cgc?ctg?ggc?aag?cga 403

Gly?Gln?Tyr?Ile?Ala?Ser?Val?Pro?Ala?Gln?Gln?Arg?Leu?Gly?Lys?Arg

90 95 100

tgg?ttc?act?ggt?tcc?gcg?gat?gca?att?ttg?cag?tct?ctg?aac?ttg?atc 451

Trp?Phe?Thr?Gly?Ser?Ala?Asp?Ala?Ile?Leu?Gln?Ser?Leu?Asn?Leu?Ile

105 110 115

tct?gat?gag?aaa?ccg?gat?tat?gtc?atc?gtt?ttc?ggc?gcg?gac?cac?gtg 499

Ser?Asp?Glu?Lys?Pro?Asp?Tyr?Val?Ile?Val?Phe?Gly?Ala?Asp?His?Val

120 125 130

tat?cgc?atg?gac?cca?agc?cag?atg?cta?gat?gag?cac?att?gca?tct?ggt 547

Tyr?Arg?Met?Asp?Pro?Ser?Gln?Met?Leu?Asp?Glu?His?Ile?Ala?Ser?Gly

135 140 145

cgc?gcg?gtg?tct?gtg?gca?ggt?att?cgc?gtt?cca?cgt?gag?gaa?gca?act 595

Arg?Ala?Val?Ser?Val?Ala?Gly?Ile?Arg?Val?Pro?Arg?Glu?Glu?Ala?Thr

150 155 160 165

gcg?ttt?ggt?tgc?atc?cag?tcc?gat?gtc?gac?ggc?aac?ata?acc?gag?ttc 643

Ala?Phe?Gly?Cys?Ile?Gln?Ser?Asp?Val?Asp?Gly?Asn?Ile?Thr?Glu?Phe

170 175 180

ttg?gaa?aag?cca?gct?gac?cct?ccg?gga?acc?cct?gat?gat?cct?gac?atg 691

Leu?Glu?Lys?Pro?Ala?Asp?Pro?Pro?Gly?Thr?Pro?Asp?Asp?Pro?Asp?Met

185 190 195

act?tac?gcg?tcg?atg?ggt?aac?tac?att?ttc?acc?act?gaa?gcc?ctg?atc 739

Thr?Tyr?Ala?Ser?Met?Gly?Asn?Tyr?Ile?Phe?Thr?Thr?Glu?Ala?Leu?Ile

200 205 210

cag?gcg?ctg?aaa?gat?gat?gaa?aat?aac?gag?aac?agt?gat?cat?gac?atg 787

Gln?Ala?Leu?Lys?Asp?Asp?Glu?Asn?Asn?Glu?Asn?Ser?Asp?His?Asp?Met

215 220 225

ggc?gga?gac?atc?att?ccg?tac?ttc?gtc?tct?cgc?aat?gat?gcg?cat?gtt 835

Gly?Gly?Asp?Ile?Ile?Pro?Tyr?Phe?Val?Ser?Arg?Asn?Asp?Ala?His?Val

230 235 240 245

tat?gat?ttc?tcc?gga?aac?att?gtt?cct?ggc?gca?act?gag?cgt?gac?aag 883

Tyr?Asp?Phe?Ser?Gly?Asn?Ile?Val?Pro?Gly?Ala?Thr?Glu?Arg?Asp?Lys

250 255 260

ggc?tac?tgg?cgc?gac?gtc?ggt?acc?att?gat?gcg?ttc?tac?gag?tgc?cac 931

Gly?Tyr?Trp?Arg?Asp?Val?Gly?Thr?Ile?Asp?Ala?Phe?Tyr?Glu?Cys?His

265 270 275

atg?gac?ctg?att?tcc?gtg?cac?cca?atc?ttc?aat?ctg?tat?aac?tct?gag 979

Met?Asp?Leu?Ile?Ser?Val?His?Pro?Ile?Phe?Asn?Leu?Tyr?Asn?Ser?Glu

280 285 290

tgg?cca?atc?cac?acg?acc?tct?gaa?ggt?aac?ttg?cct?ccg?gct?aag?ttc 1027

Trp?Pro?Ile?His?Thr?Thr?Ser?Glu?Gly?Asn?Leu?Pro?Pro?Ala?Lys?Phe

295 300 305

gtt?cgg?ggc?ggt?atc?gcg?cag?tcg?tcg?atg?gtg?tct?tca?ggt?tcc?atc 1075

Val?Arg?Gly?Gly?Ile?Ala?Gln?Ser?Ser?Met?Val?Ser?Ser?Gly?Ser?Ile

310 315 320 325

att?tct?gct?ggg?act?gtt?cgc?aac?tcc?gtg?ctg?tcc?aac?aac?gtt?gtc 1123

Ile?Ser?Ala?Gly?Thr?Val?Arg?Asn?Ser?Val?Leu?Ser?Asn?Asn?Val?Val

330 335 340

gtc?gaa?gag?ggc?gca?acg?gtg?gaa?ggt?gca?gtg?ctg?atg?cca?ggc?gtg 1171

Val?Glu?Glu?Gly?Ala?Thr?Val?Glu?Gly?Ala?Val?Leu?Met?Pro?Gly?Val

345 350 355

cgc?atc?ggt?aag?ggt?gct?gtt?gtc?cgc?cat?gcg?att?ctg?gac?aag?aac 1219

Arg?Ile?Gly?Lys?Gly?Ala?Val?Val?Arg?His?Ala?Ile?Leu?Asp?Lys?Asn

360 365 370

gtg?gtt?gtc?cgc?gac?gga?gag?ctc?atc?ggt?gtc?gac?caa?gtg?cgc?gat 1267

Val?Val?Val?Arg?Asp?Gly?Glu?Leu?Ile?Gly?Val?Asp?Gln?Val?Arg?Asp

375 380 385

gcg?cag?cgc?ttc?aag?gtg?agc?gcc?ggc?ggc?gtc?gtg?gtt?gtc?ggt?aag 1315

Ala?Gln?Arg?Phe?Lys?Val?Ser?Ala?Gly?Gly?Val?Val?Val?Val?Gly?Lys

390 395 400 405

aac?cag?gta?gtc?taaacgggaa?agggacctta?aaa 1350

Asn?Gln?Val?Val

<210>276

<211>409

<212>PRT

＜213〉Corynebacterium glutamicum

<400>276

Met?Val?Lys?Gly?Val?Lys?Gly?Arg?Pro?Asn?Val?Leu?Ala?Ile?Val?Leu

1 5 10 15

Ala?Gly?Gly?Glu?Gly?Lys?Arg?Leu?Phe?Pro?Leu?Thr?Glu?Asp?Arg?Ala

20 25 30

Lys?Pro?Ala?Val?Pro?Phe?Gly?Gly?Thr?Tyr?Arg?Leu?Ile?Asp?Phe?Val

35 40 45

Leu?Ser?Asn?Leu?Val?Asn?Ser?Gly?Phe?Leu?Lys?Ile?Ala?Val?Leu?Thr

50 55 60

Gln?Tyr?Lys?Ser?His?Ser?Leu?Asp?Arg?His?Ile?Ser?Leu?Ser?Trp?Asn

65 70 75 80

Val?Ser?Gly?Pro?Thr?Gly?Gln?Tyr?Ile?Ala?Ser?Val?Pro?Ala?Gln?Gln

85 90 95

Arg?Leu?Gly?Lys?Arg?Trp?Phe?Thr?Gly?Ser?Ala?Asp?Ala?Ile?Leu?Gln

100 105 110

Ser?Leu?Asn?Leu?Ile?Ser?Asp?Glu?Lys?Pro?Asp?Tyr?Val?Ile?Val?Phe

115 120 125

Gly?Ala?Asp?His?Val?Tyr?Arg?Met?Asp?Pro?Ser?Gln?Met?Leu?Asp?Glu

130 135 140

His?Ile?Ala?Ser?Gly?Arg?Ala?Val?Ser?Val?Ala?Gly?Ile?Arg?Val?Pro

145 150 155 160

Arg?Glu?Glu?Ala?Thr?Ala?Phe?Gly?Cys?Ile?Gln?Ser?Asp?Val?Asp?Gly

165 170 175

Asn?Ile?Thr?Glu?Phe?Leu?Glu?Lys?Pro?Ala?Asp?Pro?Pro?Gly?Thr?Pro

180 185 190

Asp?Asp?Pro?Asp?Met?Thr?Tyr?Ala?Ser?Met?Gly?Asn?Tyr?Ile?Phe?Thr

195 200 205

Thr?Glu?Ala?Leu?Ile?Gln?Ala?Leu?Lys?Asp?Asp?Glu?Asn?Asn?Glu?Asn

210 215 220

Ser?Asp?His?Asp?Met?Gly?Gly?Asp?Ile?Ile?Pro?Tyr?Phe?Val?Ser?Arg

225 230 235 240

Asn?Asp?Ala?His?Val?Tyr?Asp?Phe?Ser?Gly?Asn?Ile?Val?Pro?Gly?Ala

245 250 255

Thr?Glu?Arg?Asp?Lys?Gly?Tyr?Trp?Arg?Asp?Val?Gly?Thr?Ile?Asp?Ala

260 265 270

Phe?Tyr?Glu?Cys?His?Met?Asp?Leu?Ile?Ser?Val?His?Pro?Ile?Phe?Asn

275 280 285

Leu?Tyr?Asn?Ser?Glu?Trp?Pro?Ile?His?Thr?Thr?Ser?Glu?Gly?Asn?Leu

290 295 300

Pro?Pro?Ala?Lys?Phe?Val?Arg?Gly?Gly?Ile?Ala?Gln?Ser?Ser?Met?Val

305 310 315 320

Ser?Ser?Gly?Ser?Ile?Ile?Ser?Ala?Gly?Thr?Val?Arg?Asn?Ser?Val?Leu

325 330 335

Ser?Asn?Asn?Val?Val?Val?Glu?Glu?Gly?Ala?Thr?Val?Glu?Gly?Ala?Val

340 345 350

Leu?Met?Pro?Gly?Val?Arg?Ile?Gly?Lys?Gly?Ala?Val?Val?Arg?His?Ala

355 360 365

Ile?Leu?Asp?Lys?Asn?Val?Val?Val?Arg?Asp?Gly?Glu?Leu?Ile?Gly?Val

370 375 380

Asp?Gln?Val?Arg?Asp?Ala?Gln?Arg?Phe?Lys?Val?Ser?Ala?Gly?Gly?Val

385 390 395 400

Val?Val?Val?Gly?Lys?Asn?Gln?Val?Val

405

<210>277

<211>903

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..?(880)

<223>RXN00014

<400>277

catcaaagtg?accgccggcg?gcgtcgaatg?gtccgttgca?ggaaacgcgg?aagcagttag?60

tgagatctcc?gaaactttaa?gcgcactaga?ctaacaacac?atg?agc?aaa?tat?gca 115

Met?Ser?Lys?Tyr?Ala

1 5

gac?gat?tta?gcc?tta?gcc?ctc?gaa?ctt?gcc?gaa?ctt?gcc?gat?tcc?atc 163

Asp?Asp?Leu?Ala?Leu?Ala?Leu?Glu?Leu?Ala?Glu?Leu?Ala?Asp?Ser?Ile

10 15 20

acc?ctc?gac?cgc?ttc?gaa?gcc?tct?gac?ctg?gaa?gta?tcc?tcc?aag?cca 211

Thr?Leu?Asp?Arg?Phe?Glu?Ala?Ser?Asp?Leu?Glu?Val?Ser?Ser?Lys?Pro

25 30 35

gac?atg?act?ccc?gtc?agc?gat?gcc?gac?ctg?gcg?acc?gaa?gaa?gca?ctc 259

Asp?Met?Thr?Pro?Val?Ser?Asp?Ala?Asp?Leu?Ala?Thr?Glu?Glu?Ala?Leu

40 45 50

cgt?gag?aaa?atc?gcc?acc?gcc?cgc?ccc?gcc?gac?tcc?atc?ctc?ggt?gaa 307

Arg?Glu?Lys?Ile?Ala?Thr?Ala?Arg?Pro?Ala?Asp?Ser?Ile?Leu?Gly?Glu

55 60 65

gaa?ttc?ggt?ggc?gac?gta?gaa?ttc?agc?ggc?cgc?cag?tgg?atc?atc?gac 355

Glu?Phe?Gly?Gly?Asp?Val?Glu?Phe?Ser?Gly?Arg?Gln?Trp?Ile?Ile?Asp

70 75 80 85

ccc?atc?gac?ggc?acc?aaa?aac?tac?gtc?cgc?ggc?gtc?ccc?gta?tgg?gca 403

Pro?Ile?Asp?Gly?Thr?Lys?Asn?Tyr?Val?Arg?Gly?Val?Pro?Val?Trp?Ala

90 95 100

acc?ctg?atc?gcg?ctg?ctc?gac?aac?ggc?aaa?ccc?gtc?gca?ggt?gtc?atc 451

Thr?Leu?Ile?Ala?Leu?Leu?Asp?Asn?Gly?Lys?Pro?Val?Ala?Gly?Val?Ile

105 110 115

tcc?gca?ccc?gca?ctg?gct?agg?cgt?tgg?tgg?gca?tcc?gaa?ggg?gcc?ggc 499

Ser?Ala?Pro?Ala?Leu?Ala?Arg?Arg?Trp?Trp?Ala?Ser?Glu?Gly?Ala?Gly

120 125 130

gca?tgg?cgc?acc?ttc?aac?ggc?agc?tcc?cca?cgc?aaa?ctg?tcc?gtg?tcc 547

Ala?Trp?Arg?Thr?Phe?Asn?Gly?Ser?Ser?Pro?Arg?Lys?Leu?Ser?Val?Ser

135 140 145

cag?gtg?tcc?aag?ctt?gac?gac?gcc?tcc?ctc?tcc?ttc?tcc?tcc?ctc?tcc 595

Gln?Val?Ser?Lys?Leu?Asp?Asp?Ala?Ser?Leu?Ser?Phe?Ser?Ser?Leu?Ser

150 155 160 165

ggc?tgg?gcc?gaa?cga?gat?ttg?cgc?gat?cag?ttc?gtc?tcc?cta?act?gat 643

Gly?Trp?Ala?Glu?Arg?Asp?Leu?Arg?Asp?Gln?Phe?Val?Ser?Leu?Thr?Asp

170 175 180

acc?acc?tgg?cga?ctc?cgc?ggc?tac?ggc?gac?ttc?ttc?tcc?tac?tgc?ctc 691

Thr?Thr?Trp?Arg?Leu?Arg?Gly?Tyr?Gly?Asp?Phe?Phe?Ser?Tyr?Cys?Leu

185 190 195

gtc?gcc?gaa?ggt?gcc?gtc?gat?atc?gcc?gct?gaa?cca?gaa?gtc?agc?ctc 739

Val?Ala?Glu?Gly?Ala?Val?Asp?Ile?Ala?Ala?Glu?Pro?Glu?Val?Ser?Leu

200 205 210

tgg?gat?ctt?gct?ccc?ctg?tcc?atc?ctg?gtc?acc?gaa?gcc?gga?gga?aag 787

Trp?Asp?Leu?Ala?Pro?Leu?Ser?Ile?Leu?Val?Thr?Glu?Ala?Gly?Gly?Lys

215 220 225

ttc?acc?tca?ctg?gct?ggc?gtc?gat?gga?cca?cac?ggt?ggc?gat?gca?gta 835

Phe?Thr?Ser?Leu?Ala?Gly?Val?Asp?Gly?Pro?His?Gly?Gly?Asp?Ala?Val

230 235 240 245

gcc?acc?aac?ggc?atc?ctg?cac?gat?gag?acg?ctg?gat?cgt?tta?aaa 880

Ala?Thr?Asn?Gly?Ile?Leu?His?Asp?Glu?Thr?Leu?Asp?Arg?Leu?Lys

250 255 260

tagactcccg?ggttttgctt?ggt 903

<210>278

<211>260

<212>PRT

＜213〉Corynebacterium glutamicum

<400>278

Met?Ser?Lys?Tyr?Ala?Asp?Asp?Leu?Ala?Leu?Ala?Leu?Glu?Leu?Ala?Glu

1 5 10 15

Leu?Ala?Asp?Ser?Ile?Thr?Leu?Asp?Arg?Phe?Glu?Ala?Ser?Asp?Leu?Glu

20 25 30

Val?Ser?Ser?Lys?Pro?Asp?Met?Thr?Pro?Val?Ser?Asp?Ala?Asp?Leu?Ala

35 40 45

Thr?Glu?Glu?Ala?Leu?Arg?Glu?Lys?Ile?Ala?Thr?Ala?Arg?Pro?Ala?Asp

50 55 60

Ser?Ile?Leu?Gly?Glu?Glu?Phe?Gly?Gly?Asp?Val?Glu?Phe?Ser?Gly?Arg

65 70 75 80

Gln?Trp?Ile?Ile?Asp?Pro?Ile?Asp?Gly?Thr?Lys?Asn?Tyr?Val?Arg?Gly

85 90 95

Val?Pro?Val?Trp?Ala?Thr?Leu?Ile?Ala?Leu?Leu?Asp?Asn?Gly?Lys?Pro

100 105 110

Val?Ala?Gly?Val?Ile?Ser?Ala?Pro?Ala?Leu?Ala?Arg?Arg?Trp?Trp?Ala

115 120 125

Ser?Glu?Gly?Ala?Gly?Ala?Trp?Arg?Thr?Phe?Asn?Gly?Ser?Ser?Pro?Arg

130 135 140

Lys?Leu?Ser?Val?Ser?Gln?Val?Ser?Lys?Leu?Asp?Asp?Ala?Ser?Leu?Ser

145 150 155 160

Phe?Ser?Ser?Leu?Ser?Gly?Trp?Ala?Glu?Arg?Asp?Leu?Arg?Asp?Gln?Phe

165 170 175

Val?Ser?Leu?Thr?Asp?Thr?Thr?Trp?Arg?Leu?Arg?Gly?Tyr?Gly?Asp?Phe

180 185 190

Phe?Ser?Tyr?Cys?Leu?Val?Ala?Glu?Gly?Ala?Val?Asp?Ile?Ala?Ala?Glu

195 200 205

Pro?Glu?Val?Ser?Leu?Trp?Asp?Leu?Ala?Pro?Leu?Ser?Ile?Leu?Val?Thr

210 215 220

Glu?Ala?Gly?Gly?Lys?Phe?Thr?Ser?Leu?Ala?Gly?Val?Asp?Gly?Pro?His

225 230 235 240

Gly?Gly?Asp?Ala?Val?Ala?Thr?Asn?Gly?Ile?Leu?His?Asp?Glu?Thr?Leu

245 250 255

Asp?Arg?Leu?Lys

260

<210>279

<211>903

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(880)

<223>FRXA00014

<400>279

catcaaagtg?accgccggcg?gcgtcgaatg?gtccgttgca?ggaaacgcgg?aagcagttag?60

tgagatctcc?gaaactttaa?gcgcactaga?ctagcaacac?atg?agc?aaa?tat?gca 115

Met?Ser?Lys?Tyr?Ala

1 5

gac?gat?tta?gcc?tta?gcc?ctc?gaa?ctc?gcc?gaa?ctt?gcc?gat?tcc?atc 163

Asp?Asp?Leu?Ala?Leu?Ala?Leu?Glu?Leu?Ala?Glu?Leu?Ala?Asp?Ser?Ile

10 15 20

acc?ctc?gac?cgc?ttc?gaa?gcc?tct?gac?ctg?gaa?gta?tcc?tcc?aag?cca 211

Thr?Leu?Asp?Arg?Phe?Glu?Ala?Ser?Asp?Leu?Glu?Val?Ser?Ser?Lys?Pro

25 30 35

gac?atg?act?ccc?gtc?agc?gat?gcc?gac?ctg?gcg?acc?gaa?gaa?gca?ctc 259

Asp?Met?Thr?Pro?Val?Ser?Asp?Ala?Asp?Leu?Ala?Thr?Glu?Glu?Ala?Leu

40 45 50

cgc?gag?aaa?atc?gcc?acc?gcc?cgc?ccc?gcc?gac?tcc?atc?ctc?ggt?gaa 307

Arg?Glu?Lys?Ile?Ala?Thr?Ala?Arg?Pro?Ala?Asp?Ser?Ile?Leu?Gly?Glu

55 60 65

gaa?ttc?ggt?ggc?gac?gta?gaa?ttc?agc?ggc?cgc?cag?tgg?atc?atc?gac 355

Glu?Phe?Gly?Gly?Asp?Val?Glu?Phe?Ser?Gly?Arg?Gln?Trp?Ile?Ile?Asp

70 75 80 85

ccc?atc?gac?ggc?acc?aaa?aac?tac?gtc?cgc?ggc?gtc?ccc?gta?tgg?gca 403

Pro?Ile?Asp?Gly?Thr?Lys?Asn?Tyr?Val?Arg?Gly?Val?Pro?Val?Trp?Ala

90 95 100

acc?ctg?atc?gcg?ctg?ctc?gac?aac?ggc?aaa?ccc?gtc?gca?ggt?gtc?atc 451

Thr?Leu?Ile?Ala?Leu?Leu?Asp?Asn?Gly?Lys?Pro?Val?Ala?Gly?Val?Ile

105 110 115

tcc?gca?ccc?gca?ctg?gct?agg?cgt?tgg?tgg?gca?tcc?gaa?ggg?gcc?ggc 499

Ser?Ala?Pro?Ala?Leu?Ala?Arg?Arg?Trp?Trp?Ala?Ser?Glu?Gly?Ala?Gly

120 125 130

gca?tgg?cgc?acc?ttc?aac?ggc?agc?tcc?cca?cgc?aaa?ctg?tcc?gtg?tcc 547

Ala?Trp?Arg?Thr?Phe?Asn?Gly?Ser?Ser?Pro?Arg?Lys?Leu?Ser?Val?Ser

135 140 145

cag?gtg?tcc?aag?ctt?gac?gac?gcc?tcc?ctc?tcc?ttc?tcc?tcc?ctc?tcc 595

Gln?Val?Ser?Lys?Leu?Asp?Asp?Ala?Ser?Leu?Ser?Phe?Ser?Ser?Leu?Ser

150 155 160 165

ggc?tgg?gcc?gaa?cga?gat?ttg?cgc?gat?cag?ttc?gtc?tcc?cta?act?gat 643

Gly?Trp?Ala?Glu?Arg?Asp?Leu?Arg?Asp?Gln?Phe?Val?Ser?Leu?Thr?Asp

170 175 180

acc?acc?tgg?cga?ctc?cgc?ggc?tac?ggc?gac?ttc?ttc?tcc?tac?tgc?ctc 691

Thr?Thr?Trp?Arg?Leu?Arg?Gly?Tyr?Gly?Asp?Phe?Phe?Ser?Tyr?Cys?Leu

185 190 195

gtc?gcc?gaa?ggt?gcc?gtc?gat?atc?gcc?gct?gaa?cca?gaa?gtc?agc?ctc 739

Val?Ala?Glu?Gly?Ala?Val?Asp?Ile?Ala?Ala?Glu?Pro?Glu?Val?Ser?Leu

200 205 210

tgg?gat?ctt?gct?ccc?ctg?tcc?atc?ctg?gtc?acc?gaa?gcc?gga?gga?aag 787

Trp?Asp?Leu?Ala?Pro?Leu?Ser?Ile?Leu?Val?Thr?Glu?Ala?Gly?Gly?Lys

215 220 225

ttc?acc?tca?ctg?gct?ggc?gtc?gat?gga?cca?cac?ggt?ggc?gat?gca?gta 835

Phe?Thr?Ser?Leu?Ala?Gly?Val?Asp?Gly?Pro?His?Gly?Gly?Asp?Ala?Val

230 235 240 245

gcc?acc?aac?ggc?atc?ctg?cac?gat?gag?acg?ctg?gat?cgt?tta?aaa 880

Ala?Thr?Asn?Gly?Ile?Leu?His?Asp?Glu?Thr?Leu?Asp?Arg?Leu?Lys

250 255 260

tagactcccg?ggttttgctt?ggt 903

<210>280

<211>260

<212>PRT

＜213〉Corynebacterium glutamicum

<400>280

Met?Ser?Lys?Tyr?Ala?Asp?Asp?Leu?Ala?Leu?Ala?Leu?Glu?Leu?Ala?Glu

1 5 10 15

Leu?Ala?Asp?Ser?Ile?Thr?Leu?Asp?Arg?Phe?Glu?Ala?Ser?Asp?Leu?Glu

20 25 30

Val?Ser?Ser?Lys?Pro?Asp?Met?Thr?Pro?Val?Ser?Asp?Ala?Asp?Leu?Ala

35 40 45

Thr?Glu?Glu?Ala?Leu?Arg?Glu?Lys?Ile?Ala?Thr?Ala?Arg?Pro?Ala?Asp

50 55 60

Ser?Ile?Leu?Gly?Glu?Glu?Phe?Gly?Gly?Asp?Val?Glu?Phe?Ser?Gly?Arg

65 70 75 80

Gln?Trp?Ile?Ile?Asp?Pro?Ile?Asp?Gly?Thr?Lys?Asn?Tyr?Val?Arg?Gly

85 90 95

Val?Pro?Val?Trp?Ala?Thr?Leu?Ile?Ala?Leu?Leu?Asp?Asn?Gly?Lys?Pro

100 105 110

Val?Ala?Gly?Val?Ile?Ser?Ala?Pro?Ala?Leu?Ala?Arg?Arg?Trp?Trp?Ala

115 120 125

Ser?Glu?Gly?Ala?Gly?Ala?Trp?Arg?Thr?Phe?Asn?Gly?Ser?Ser?Pro?Arg

130 135 140

Lys?Leu?Ser?Val?Ser?Gln?Val?Ser?Lys?Leu?Asp?Asp?Ala?Ser?Leu?Ser

145 150 155 160

Phe?Ser?Ser?Leu?Ser?Gly?Trp?Ala?Glu?Arg?Asp?Leu?Arg?Asp?Gln?Phe

165 170 175

Val?Ser?Leu?Thr?Asp?Thr?Thr?Trp?Arg?Leu?Arg?Gly?Tyr?Gly?Asp?Phe

180 185 190

Phe?Ser?Tyr?Cys?Leu?Val?Ala?Glu?Gly?Ala?Val?Asp?Ile?Ala?Ala?Glu

195 200 205

Pro?Glu?Val?Ser?Leu?Trp?Asp?Leu?Ala?Pro?Leu?Ser?Ile?Leu?Val?Thr

210 215 220

Glu?Ala?Gly?Gly?Lys?Phe?Thr?Ser?Leu?Ala?Gly?Val?Asp?Gly?Pro?His

225 230 235 240

Gly?Gly?Asp?Ala?Val?Ala?Thr?Asn?Gly?Ile?Leu?His?Asp?Glu?Thr?Leu

245 250 255

Asp?Arg?Leu?Lys

260

<210>281

<211>978

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(955)

<223>RXA01570

<400>281

cactgaactc?cgttttggat?ctcggcaaaa?tcgaagccac?cggatttagc?gcaccgacct?60

ggcagacccg?cctcaacgac?tacctcaagg?aactctcaaa?gtg?aaa?ggc?atc?atc 115

Val?Lys?Gly?Ile?Ile

1 5

ctc?gca?ggt?ggc?tcc?ggc?acc?cgg?ctc?tac?ccc?atc?acc?aag?ggc?atc 163

Leu?Ala?Gly?Gly?Ser?Gly?Thr?Arg?Leu?Tyr?Pro?Ile?Thr?Lys?Gly?Ile

10 15 20

tcc?aag?caa?ctg?atg?ccg?att?tac?gac?aaa?ccc?atg?gtc?tac?tac?cca 211

Ser?Lys?Gln?Leu?Met?Pro?Ile?Tyr?Asp?Lys?Pro?Met?Val?Tyr?Tyr?Pro

25 30 35

ctg?acc?acg?ctc?att?cag?gcc?ggc?atc?aaa?gac?atc?ctg?att?atc?acc 259

Leu?Thr?Thr?Leu?Ile?Gln?Ala?Gly?Ile?Lys?Asp?Ile?Leu?Ile?Ile?Thr

40 45 50

acc?cct?gaa?gac?agc?gcc?tcc?ttt?gaa?cgc?ttg?ctt?ggc?gac?ggc?tcc 307

Thr?Pro?Glu?Asp?Ser?Ala?Ser?Phe?Glu?Arg?Leu?Leu?Gly?Asp?Gly?Ser

55 60 65

tcc?tgg?ggc?atc?aac?ctc?acc?tac?gcc?gtc?caa?ccc?tcc?ccc?gac?gga 355

Ser?Trp?Gly?Ile?Asn?Leu?Thr?Tyr?Ala?Val?Gln?Pro?Ser?Pro?Asp?Gly

70 75 80 85

cta?gcc?caa?gca?ttc?atc?atc?ggc?gag?gaa?ttc?atc?ggt?gac?gac?gac 403

Leu?Ala?Gln?Ala?Phe?Ile?Ile?Gly?Glu?Glu?Phe?Ile?Gly?Asp?Asp?Asp

90 95 100

gtc?gcg?ttg?gtg?ctt?ggc?gat?aac?atc?ttc?gac?ggc?gca?caa?ctt?ggc 451

Val?Ala?Leu?Val?Leu?Gly?Asp?Asn?Ile?Phe?Asp?Gly?Ala?Gln?Leu?Gly

105 110 115

cac?gca?cta?aag?cag?tgc?tcc?aac?ccc?gac?ggt?ggc?att?gtc?ttt?gct 499

His?Ala?Leu?Lys?Gln?Cys?Ser?Asn?Pro?Asp?Gly?Gly?Ile?Val?Phe?Ala

120 125 130

tat?gag?gtc?tcc?gat?cct?gag?cgt?tat?ggc?gtg?gtg?gaa?ttt?gat?gct 547

Tyr?Glu?Val?Ser?Asp?Pro?Glu?Arg?Tyr?Gly?Val?Val?Glu?Phe?Asp?Ala

135 140 145

gct?aat?aag?gcg?gtg?tct?att?gaa?gaa?aag?ccc?acc?gcg?cca?aaa?tcc 595

Ala?Asn?Lys?Ala?Val?Ser?Ile?Glu?Glu?Lys?Pro?Thr?Ala?Pro?Lys?Ser

150 155 160 165

aac?ttt?gcc?gtg?gta?gga?cta?tat?ttc?tac?gac?aat?cgc?gtg?gtg?gac 643

Asn?Phe?Ala?Val?Val?Gly?Leu?Tyr?Phe?Tyr?Asp?Asn?Arg?Val?Val?Asp

170 175 180

atc?gcc?aag?tca?atc?aag?cct?tcc?tcg?cgt?ggc?gaa?ctg?gaa?atc?acc 691

Ile?Ala?Lys?Ser?Ile?Lys?Pro?Ser?Ser?Arg?Gly?Glu?Leu?Glu?Ile?Thr

185 190 195

tcc?gtt?aac?gat?gcc?tac?ctc?cag?caa?ggt?gct?tta?act?gtg?cag?cgc 739

Ser?Val?Asn?Asp?Ala?Tyr?Leu?Gln?Gln?Gly?Ala?Leu?Thr?Val?Gln?Arg

200 205 210

ctg?gac?cgt?ggc?gat?gtc?tgg?tta?gat?acc?ggc?aca?atc?gat?tcc?atg 787

Leu?Asp?Arg?Gly?Asp?Val?Trp?Leu?Asp?Thr?Gly?Thr?Ile?Asp?Ser?Met

215 220 225

tcc?gag?gcg?tct?tcc?tat?gtt?gag?gtc?ctg?caa?aaa?cgt?acc?ggc?aac 835

Ser?Glu?Ala?Ser?Ser?Tyr?Val?Glu?Val?Leu?Gln?Lys?Arg?Thr?Gly?Asn

230 235 240 245

atc?atc?gga?tcc?ccc?gaa?gtc?gct?gcg?tac?cgc?gaa?ggt?ttc?atc?aca 883

Ile?Ile?Gly?Ser?Pro?Glu?Val?Ala?Ala?Tyr?Arg?Glu?Gly?Phe?Ile?Thr

250 255 260

gct?gaa?gaa?ctc?aca?gtg?ctt?ggt?gag?gaa?ctg?aag?aaa?tca?ggc?tac 931

Ala?Glu?Glu?Leu?Thr?Val?Leu?Gly?Glu?Glu?Leu?Lys?Lys?Ser?Gly?Tyr

265 270 275

gga?aac?tac?ctg?ctg?aga?gct?ttg?taatttacgg?tgtggttgtg?gag 978

Gly?Asn?Tyr?Leu?Leu?Arg?Ala?Leu

280 285

<210>282

<211>285

<212>PRT

＜213〉Corynebacterium glutamicum

<400>282

Val?Lys?Gly?Ile?Ile?Leu?Ala?Gly?Gly?Ser?Gly?Thr?Arg?Leu?Tyr?Pro

1 5 10 15

Ile?Thr?Lys?Gly?Ile?Ser?Lys?Gln?Leu?Met?Pro?Ile?Tyr?Asp?Lys?Pro

20 25 30

Met?Val?Tyr?Tyr?Pro?Leu?Thr?Thr?Leu?Ile?Gln?Ala?Gly?Ile?Lys?Asp

35 40 45

Ile?Leu?Ile?Ile?Thr?Thr?Pro?Glu?Asp?Ser?Ala?Ser?Phe?Glu?Arg?Leu

50 55 60

Leu?Gly?Asp?Gly?Ser?Ser?Trp?Gly?Ile?Asn?Leu?Thr?Tyr?Ala?Val?Gln

65 70 75 80

Pro?Ser?Pro?Asp?Gly?Leu?Ala?Gln?Ala?Phe?Ile?Ile?Gly?Glu?Glu?Phe

85 90 95

Ile?Gly?Asp?Asp?Asp?Val?Ala?Leu?Val?Leu?Gly?Asp?Asn?Ile?Phe?Asp

100 105 110

Gly?Ala?Gln?Leu?Gly?His?Ala?Leu?Lys?Gln?Cys?Ser?Asn?Pro?Asp?Gly

115 120 125

Gly?Ile?Val?Phe?Ala?Tyr?Glu?Val?Ser?Asp?Pro?Glu?Arg?Tyr?Gly?Val

130 135 140

Val?Glu?Phe?Asp?Ala?Ala?Asn?Lys?Ala?Val?Ser?Ile?Glu?Glu?Lys?Pro

145 150 155 160

Thr?Ala?Pro?Lys?Ser?Asn?Phe?Ala?Val?Val?Gly?Leu?Tyr?Phe?Tyr?Asp

165 170 175

Asn?Arg?Val?Val?Asp?Ile?Ala?Lys?Ser?Ile?Lys?Pro?Ser?Ser?Arg?Gly

180 185 190

Glu?Leu?Glu?Ile?Thr?Ser?Val?Asn?Asp?Ala?Tyr?Leu?Gln?Gln?Gly?Ala

195 200 205

Leu?Thr?Val?Gln?Arg?Leu?Asp?Arg?Gly?Asp?Val?Trp?Leu?Asp?Thr?Gly

210 215 220

Thr?Ile?Asp?Ser?Met?Ser?Glu?Ala?Ser?Ser?Tyr?Val?Glu?Val?Leu?Gln

225 230 235 240

Lys?Arg?Thr?Gly?Asn?Ile?Ile?Gly?Ser?Pro?Glu?Val?Ala?Ala?Tyr?Arg

245 250 255

Glu?Gly?Phe?Ile?Thr?Ala?Glu?Glu?Leu?Thr?Val?Leu?Gly?Glu?Glu?Leu

260 265 270

Lys?Lys?Ser?Gly?Tyr?Gly?Asn?Tyr?Leu?Leu?Arg?Ala?Leu

275 280 285

<210>283

<211>891

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(868)

<223>RXA02666

<400>283

gctcggcgac?gaggaagaga?agaaggacgc?attcgacgac?ttcgacgatt?ccgacgtgga?60

tcttgacgat?ctgagcttcg?acgacgaaga?ttagacgccc?atg?tcg?tct?aca?cga 115

Met?Ser?Ser?Thr?Arg

1 5

atc?ccc?gtc?atc?gca?ctc?ctc?gcg?gcg?gcg?ggg?cgc?gga?acc?cgc?ctc 163

Ile?Pro?Val?Ile?Ala?Leu?Leu?Ala?Ala?Ala?Gly?Arg?Gly?Thr?Arg?Leu

10 15 20

ggc?gga?ccc?atc?ccc?aaa?gca?ttc?gtc?acg?ttg?cgt?gaa?cgc?aca?ctt 211

Gly?Gly?Pro?Ile?Pro?Lys?Ala?Phe?Val?Thr?Leu?Arg?Glu?Arg?Thr?Leu

25 30 35

tta?gag?cgc?tcg?ctc?caa?gcc?atg?ctc?acc?tcc?gaa?agc?gtc?gac?gaa 259

Leu?Glu?Arg?Ser?Leu?Gln?Ala?Met?Leu?Thr?Ser?Glu?Ser?Val?Asp?Glu

40 45 50

atc?atc?atc?ctc?gtc?agc?ccc?gac?atg?gaa?acc?tac?gcc?cgc?gat?ttg 307

Ile?Ile?Ile?Leu?Val?Ser?Pro?Asp?Met?Glu?Thr?Tyr?Ala?Arg?Asp?Leu

55 60 65

ctg?cgc?aaa?cgc?ggt?ctt?ttg?aac?gac?ccc?gaa?ggg?gta?cgc?gta?cgg 355

Leu?Arg?Lys?Arg?Gly?Leu?Leu?Asn?Asp?Pro?Glu?Gly?Val?Arg?Val?Arg

70 75 80 85

ctc?gtg?cac?ggc?ggc?ggg?gag?cgc?gcg?gac?tcg?gtc?tgg?gca?ggc?ctt 403

Leu?Val?His?Gly?Gly?Gly?Glu?Arg?Ala?Asp?Ser?Val?Trp?Ala?Gly?Leu

90 95 100

cag?gca?att?tcg?ctt?gac?gac?gcc?acc?ccc?gat?gca?att?gtc?tta?atc 451

Gln?Ala?Ile?Ser?Leu?Asp?Asp?Ala?Thr?Pro?Asp?Ala?Ile?Val?Leu?Ile

105 110 115

cac?gac?agc?gcc?cga?gcg?ctc?aca?cca?ccc?ggc?atg?att?gcg?cgc?gtg 499

His?Asp?Ser?Ala?Arg?Ala?Leu?Thr?Pro?Pro?Gly?Met?Ile?Ala?Arg?Val

120 125 130

gtg?cgc?aaa?gtc?cac?gaa?ggc?gcc?acc?gca?gtc?atc?cca?gta?ctg?cca 547

Val?Arg?Lys?Val?His?Glu?Gly?Ala?Thr?Ala?Val?Ile?Pro?Val?Leu?Pro

135 140 145

gta?tcg?gac?acc?atc?aaa?cga?gtg?tcc?cct?gat?ggc?gga?gta?gtt?gtc 595

Val?Ser?Asp?Thr?Ile?Lys?Arg?Val?Ser?Pro?Asp?Gly?Gly?Val?Val?Val

150 155 160 165

gac?aca?ccc?aac?cgt?gca?gaa?ctt?cgc?gcc?gtc?caa?acc?cca?caa?ggc 643

Asp?Thr?Pro?Asn?Arg?Ala?Glu?Leu?Arg?Ala?Val?Gln?Thr?Pro?Gln?Gly

170 175 180

ttc?ctg?ctg?tcc?gaa?ctt?gtt?gca?gcg?aat?gag?aaa?ttc?ttc?gcc?gac 691

Phe?Leu?Leu?Ser?Glu?Leu?Val?Ala?Ala?Asn?Glu?Lys?Phe?Phe?Ala?Asp

185 190 195

ccc?aac?cca?ggc?ttc?atc?cca?acc?gat?gac?gcc?agc?ttg?atg?gaa?tgg 739

Pro?Asn?Pro?Gly?Phe?Ile?Pro?Thr?Asp?Asp?Ala?Ser?Leu?Met?Glu?Trp

200 205 210

tac?ggc?gca?gat?gta?gtc?tgc?gta?caa?ggc?gac?cca?atg?gcg?ttt?aaa 787

Tyr?Gly?Ala?Asp?Val?Val?Cys?Val?Gln?Gly?Asp?Pro?Met?Ala?Phe?Lys

215 220 225

gta?aca?acc?ccc?att?gat?atg?atg?ctg?gca?caa?cgc?atc?acc?gac?gaa 835

Val?Thr?Thr?Pro?Ile?Asp?Met?Met?Leu?Ala?Gln?Arg?Ile?Thr?Asp?Glu

230 235 240 245

gcc?gaa?ccc?aca?ata?ttt?gag?gta?cca?ggt?gac?taacccaatc?atcccccgcg?888

Ala?Glu?Pro?Thr?Ile?Phe?Glu?Val?Pro?Gly?Asp

250 255

tag 891

<210>284

<211>256

<212>PRT

＜213〉Corynebacterium glutamicum

<400>284

Met?Ser?Ser?Thr?Arg?Ile?Pro?Val?Ile?Ala?Leu?Leu?Ala?Ala?Ala?Gly

1 5 10 15

Arg?Gly?Thr?Arg?Leu?Gly?Gly?Pro?Ile?Pro?Lys?Ala?Phe?Val?Thr?Leu

20 25 30

Arg?Glu?Arg?Thr?Leu?Leu?Glu?Arg?Ser?Leu?Gln?Ala?Met?Leu?Thr?Ser

35 40 45

Glu?Ser?Val?Asp?Glu?Ile?Ile?Ile?Leu?Val?Ser?Pro?Asp?Met?Glu?Thr

50 55 60

Tyr?Ala?Arg?Asp?Leu?Leu?Arg?Lys?Arg?Gly?Leu?Leu?Asn?Asp?Pro?Glu

65 70 75 80

Gly?Val?Arg?Val?Arg?Leu?Val?His?Gly?Gly?Gly?Glu?Arg?Ala?Asp?Ser

85 90 95

Val?Trp?Ala?Gly?Leu?Gln?Ala?Ile?Ser?Leu?Asp?Asp?Ala?Thr?Pro?Asp

100 105 110

Ala?Ile?Val?Leu?Ile?His?Asp?Ser?Ala?Arg?Ala?Leu?Thr?Pro?Pro?Gly

115 120 125

Met?Ile?Ala?Arg?Val?Val?Arg?Lys?Val?His?Glu?Gly?Ala?Thr?Ala?Val

130 135 140

Ile?Pro?Val?Leu?Pro?Val?Ser?Asp?Thr?Ile?Lys?Arg?Val?Ser?Pro?Asp

145 150 155 160

Gly?Gly?Val?Val?Val?Asp?Thr?Pro?Asn?Arg?Ala?Glu?Leu?Arg?Ala?Val

165 170 175

Gln?Thr?Pro?Gln?Gly?Phe?Leu?Leu?Ser?Glu?Leu?Val?Ala?Ala?Asn?Glu

180 185 190

Lys?Phe?Phe?Ala?Asp?Pro?Asn?Pro?Gly?Phe?Ile?Pro?Thr?Asp?Asp?Ala

195 200 205

Ser?Leu?Met?Glu?Trp?Tyr?Gly?Ala?Asp?Val?Val?Cys?Val?Gln?Gly?Asp

210 215 220

Pro?Met?Ala?Phe?Lys?Val?Thr?Thr?Pro?Ile?Asp?Met?Met?Leu?Ala?Gln

225 230 235 240

Arg?Ile?Thr?Asp?Glu?Ala?Glu?Pro?Thr?Ile?Phe?Glu?Val?Pro?Gly?Asp

245 250 255

<210>285

<211>1056

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1033)

<223>RXA00825

<400>285

cccgttcatg?ctgggctttg?gtgcggtgat?ggcaactatt?tgtctgatca?ttgtgagttt?60

tagtgcacgc?cgattctgag?aaacaactaa?agtgagccac?atg?cgc?aca?gta?gtt 115

Met?Arg?Thr?Val?Val

1 5

acc?ggc?ggt?gcc?ggc?ttc?atc?gga?tcc?cat?ctc?gtt?gac?ctt?ttg?atc 163

Thr?Gly?Gly?Ala?Gly?Phe?Ile?Gly?Ser?His?Leu?Val?Asp?Leu?Leu?Ile

10 15 20

aag?gaa?ggc?cac?gag?gtc?gtt?gtg?atc?gat?aac?ctc?tcc?cgc?gga?cgc 211

Lys?Glu?Gly?His?Glu?Val?Val?Val?Ile?Asp?Asn?Leu?Ser?Arg?Gly?Arg

25 30 35

ctg?gag?aat?ctc?tcc?gat?gcg?gaa?gcc?acc?gga?aaa?ctc?acc?ttt?gtg 259

Leu?Glu?Asn?Leu?Ser?Asp?Ala?Glu?Ala?Thr?Gly?Lys?Leu?Thr?Phe?Val

40 45 50

gaa?gcc?gat?ctt?ctc?gac?gtt?gat?ttc?aac?gag?ttt?cta?gga?acc?cac 307

Glu?Ala?Asp?Leu?Leu?Asp?Val?Asp?Phe?Asn?Glu?Phe?Leu?Gly?Thr?His

55 60 65

aag?cct?gag?gtt?att?ttc?cac?ctg?gca?gcg?caa?atc?gat?gtg?cgc?cac 355

Lys?Pro?Glu?Val?Ile?Phe?His?Leu?Ala?Ala?Gln?Ile?Asp?Val?Arg?His

70 75 80 85

tct?gtt?gta?gat?cct?ctt?cac?gac?gcc?gaa?acc?aac?att?ttg?tcc?acc 403

Ser?Val?Val?Asp?Pro?Leu?His?Asp?Ala?Glu?Thr?Asn?Ile?Leu?Ser?Thr

90 95 100

atc?cgc?atc?gct?gac?gct?gcc?cgc?cag?cac?ggt?gtt?cgc?aag?gtt?gtc 451

Ile?Arg?Ile?Ala?Asp?Ala?Ala?Arg?Gln?His?Gly?Val?Arg?Lys?Val?Val

105 110 115

ttt?acc?tcc?tca?ggc?ggt?tcc?att?tac?ggt?gag?cct?tcg?gaa?ttc?cca 499

Phe?Thr?Ser?Ser?Gly?Gly?Ser?Ile?Tyr?Gly?Glu?Pro?Ser?Glu?Phe?Pro

120 125 130

gtt?gat?gaa?acc?gtg?cca?gtg?gat?cca?cat?tcc?cct?tat?gcg?gca?tcc 547

Val?Asp?Glu?Thr?Val?Pro?Val?Asp?Pro?His?Ser?Pro?Tyr?Ala?Ala?Ser

135 140 145

aag?gtg?tcc?ggt?gaa?att?tac?ctg?aac?acc?ttc?cgc?cac?ctg?tac?ggc 595

Lys?Val?Ser?Gly?Glu?Ile?Tyr?Leu?Asn?Thr?Phe?Arg?His?Leu?Tyr?Gly

150 155 160 165

tta?gac?tgt?tct?cac?atc?gca?ccg?gca?aat?gtt?tac?ggc?cca?cgc?caa 643

Leu?Asp?Cys?Ser?His?Ile?Ala?Pro?Ala?Asn?Val?Tyr?Gly?Pro?Arg?Gln

170 175 180

gat?cca?cac?ggt?gaa?gca?gga?gtt?gtg?gcc?att?ttc?gcg?ctg?cga?ctt 691

Asp?Pro?His?Gly?Glu?Ala?Gly?Val?Val?Ala?Ile?Phe?Ala?Leu?Arg?Leu

185 190 195

ctg?gga?ggc?ctg?gac?acc?aag?gta?ttc?ggc?gac?ggc?gga?aac?acc?cgc 739

Leu?Gly?Gly?Leu?Asp?Thr?Lys?Val?Phe?Gly?Asp?Gly?Gly?Asn?Thr?Arg

200 205 210

gac?tac?gtc?tac?gtc?ggt?gac?gta?gtt?cgt?gct?ttc?tac?ctg?gct?tct 787

Asp?Tyr?Val?Tyr?Val?Gly?Asp?Val?Val?Arg?Ala?Phe?Tyr?Leu?Ala?Ser

215 220 225

ggg?gaa?atc?ggt?ggg?gga?gag?cgc?ttc?aac?att?ggc?acc?tct?gtg?gaa 835

Gly?Glu?Ile?Gly?Gly?Gly?Glu?Arg?Phe?Asn?Ile?Gly?Thr?Ser?Val?Glu

230 235 240 245

acc?tct?gac?cgc?cag?ctg?cac?acc?ctc?gtg?gcc?act?gcg?gca?ggt?tcc 883

Thr?Ser?Asp?Arg?Gln?Leu?His?Thr?Leu?Val?Ala?Thr?Ala?Ala?Gly?Ser

250 255 260

aaa?gat?gat?cct?gaa?tat?gca?cct?gca?cgt?ctc?ggc?gat?gtg?cca?cgc 931

Lys?Asp?Asp?Pro?Glu?Tyr?Ala?Pro?Ala?Arg?Leu?Gly?Asp?Val?Pro?Arg

265 270 275

agt?gca?ctc?agc?ttc?ggc?aag?gcc?aaa?gag?gtg?ctt?ggt?tgg?gag?cct 979

Ser?Ala?Leu?Ser?Phe?Gly?Lys?Ala?Lys?Glu?Val?Leu?Gly?Trp?Glu?Pro

280 285 290

gag?gtg?aac?atc?gaa?caa?ggt?gtg?gcc?aag?act?gtg?gag?tac?ttc?cgc 1027

Glu?Val?Asn?Ile?Glu?Gln?Gly?Val?Ala?Lys?Thr?Val?Glu?Tyr?Phe?Arg

295 300 305

act?cac?taggggaaaa?tccaccacaa?atc 1056

Thr?His

310

<210>286

<211>311

<212>PRT

＜213〉Corynebacterium glutamicum

<400>286

Met?Arg?Thr?Val?Val?Thr?Gly?Gly?Ala?Gly?Phe?Ile?Gly?Ser?His?Leu

1 5 10 15

Val?Asp?Leu?Leu?Ile?Lys?Glu?Gly?His?Glu?Val?Val?Val?Ile?Asp?Asn

20 25 30

Leu?Ser?Arg?Gly?Arg?Leu?Glu?Asn?Leu?Ser?Asp?Ala?Glu?Ala?Thr?Gly

35 40 45

Lys?Leu?Thr?Phe?Val?Glu?Ala?Asp?Leu?Leu?Asp?Val?Asp?Phe?Asn?Glu

50 55 60

Phe?Leu?Gly?Thr?His?Lys?Pro?Glu?Val?Ile?Phe?His?Leu?Ala?Ala?Gln

65 70 75 80

Ile?Asp?Val?Arg?His?Ser?Val?Val?Asp?Pro?Leu?His?Asp?Ala?Glu?Thr

85 90 95

Asn?Ile?Leu?Ser?Thr?Ile?Arg?Ile?Ala?Asp?Ala?Ala?Arg?Gln?His?Gly

100 105 110

Val?Arg?Lys?Val?Val?Phe?Thr?Ser?Ser?Gly?Gly?Ser?Ile?Tyr?Gly?Glu

115 120 125

Pro?Ser?Glu?Phe?Pro?Val?Asp?Glu?Thr?Val?Pro?Val?Asp?Pro?His?Ser

130 135 140

Pro?Tyr?Ala?Ala?Ser?Lys?Val?Ser?Gly?Glu?Ile?Tyr?Leu?Asn?Thr?Phe

145 150 155 160

Arg?His?Leu?Tyr?Gly?Leu?Asp?Cys?Ser?His?Ile?Ala?Pro?Ala?Asn?Val

165 170 175

Tyr?Gly?Pro?Arg?Gln?Asp?Pro?His?Gly?Glu?Ala?Gly?Val?Val?Ala?Ile

180 185 190

Phe?Ala?Leu?Arg?Leu?Leu?Gly?Gly?Leu?Asp?Thr?Lys?Val?Phe?Gly?Asp

195 200 205

Gly?Gly?Asn?Thr?Arg?Asp?Tyr?Val?Tyr?Val?Gly?Asp?Val?Val?Arg?Ala

210 215 220

Phe?Tyr?Leu?Ala?Ser?Gly?Glu?Ile?Gly?Gly?Gly?Glu?Arg?Phe?Asn?Ile

225 230 235 240

Gly?Thr?Ser?Val?Glu?Thr?Ser?Asp?Arg?Gln?Leu?His?Thr?Leu?Val?Ala

245 250 255

Thr?Ala?Ala?Gly?Ser?Lys?Asp?Asp?Pro?Glu?Tyr?Ala?Pro?Ala?Arg?Leu

260 265 270

Gly?Asp?Val?Pro?Arg?Ser?Ala?Leu?Ser?Phe?Gly?Lys?Ala?Lys?Glu?Val

275 280 285

Leu?Gly?Trp?Glu?Pro?Glu?Val?Asn?Ile?Glu?Gln?Gly?Val?Ala?Lys?Thr

290 295 300

Val?Glu?Tyr?Phe?Arg?Thr?His

305 310

<210>287

<211>1134

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1111)

<223>RXA01887

<400>287

catctttaca?ggaaacccct?tgacggcatc?aatgggtggt?atctagtatc?tactagaacg?60

ttatagtaga?acgttctagt?aaaacttgga?aggatgaaaa?atg?tca?gtc?aaa?ctt 115

Met?Ser?Val?Lys?Leu

1 5

gcc?ctc?atc?ggt?gct?gga?cgc?atc?gga?tca?aat?cac?gca?cgc?ctg?atc 163

Ala?Leu?Ile?Gly?Ala?Gly?Arg?Ile?Gly?Ser?Asn?His?Ala?Arg?Leu?Ile

10 15 20

aca?aac?cac?gtg?atc?ggc?tct?gaa?ctg?gtc?gcc?gtc?gtt?gac?cca?act 211

Thr?Asn?His?Val?Ile?Gly?Ser?Glu?Leu?Val?Ala?Val?Val?Asp?Pro?Thr

25 30 35

ccc?aac?gca?gaa?acc?ctc?gct?gat?gaa?ttg?ggc?gcc?gtt?gcg?ttc?tct 259

Pro?Asn?Ala?Glu?Thr?Leu?Ala?Asp?Glu?Leu?Gly?Ala?Val?Ala?Phe?Ser

40 45 50

aac?cca?gat?gac?gtc?ctg?acc?cgc?gat?gac?att?gac?gcg?gtt?ttg?att 307

Asn?Pro?Asp?Asp?Val?Leu?Thr?Arg?Asp?Asp?Ile?Asp?Ala?Val?Leu?Ile

55 60 65

gct?aca?cca?gca?cga?acc?cac?gcg?gat?ctc?gtg?gtc?aaa?gca?gcg?gca 355

Ala?Thr?Pro?Ala?Arg?Thr?His?Ala?Asp?Leu?Val?Val?Lys?Ala?Ala?Ala

70 75 80 85

gcg?ggc?aag?cac?gtg?ttt?gtg?gaa?aag?ccc?atg?gcc?gtc?acc?ctc?gag 403

Ala?Gly?Lys?His?Val?Phe?Val?Glu?Lys?Pro?Met?Ala?Val?Thr?Leu?Glu

90 95 100

gac?gca?gat?cgt?gcc?atc?aac?gca?gca?cgc?gaa?gca?aac?act?gtc?ctg 451

Asp?Ala?Asp?Arg?Ala?Ile?Asn?Ala?Ala?Arg?Glu?Ala?Asn?Thr?Val?Leu

105 110 115

cag?gtg?ggc?ttc?aat?cgt?cgt?ttc?gcg?gca?ggt?ttc?gct?gca?gca?cgc 499

Gln?Val?Gly?Phe?Asn?Arg?Arg?Phe?Ala?Ala?Gly?Phe?Ala?Ala?Ala?Arg

120 125 130

gca?cgc?att?gac?gca?ggc?gat?atc?ggc?acc?cca?cag?ctg?ctt?cgt?tcc 547

Ala?Arg?Ile?Asp?Ala?Gly?Asp?Ile?Gly?Thr?Pro?Gln?Leu?Leu?Arg?Ser

135 140 145

gtg?acc?cgc?gat?cca?gga?cca?ttc?acc?gct?gac?ccc?aac?aag?atc?cct 595

Val?Thr?Arg?Asp?Pro?Gly?Pro?Phe?Thr?Ala?Asp?Pro?Asn?Lys?Ile?Pro

150 155 160 165

cag?tgg?acc?atc?ttc?ctg?gaa?acc?ctc?atc?cac?gat?ttc?gat?gcg?ctg 643

Gln?Trp?Thr?Ile?Phe?Leu?Glu?Thr?Leu?Ile?His?Asp?Phe?Asp?Ala?Leu

170 175 180

tgc?tac?ctc?aac?cca?ggc?gca?acc?cca?gtg?gaa?gta?acc?gct?cac?gct 691

Cys?Tyr?Leu?Asn?Pro?Gly?Ala?Thr?Pro?Val?Glu?Val?Thr?Ala?His?Ala

185 190 195

gat?tgc?ctc?gtc?gtt?cca?gaa?gct?gct?ggc?act?ggc?ttc?ctc?gac?acc 739

Asp?Cys?Leu?Val?Val?Pro?Glu?Ala?Ala?Gly?Thr?Gly?Phe?Leu?Asp?Thr

200 205 210

gca?gtg?gtg?act?gtc?cgt?ttt?gat?aac?gga?gca?att?ggt?act?gca?gaa 787

Ala?Val?Val?Thr?Val?Arg?Phe?Asp?Asn?Gly?Ala?Ile?Gly?Thr?Ala?Glu

215 220 225

gca?agc?ttc?agc?gca?gcc?tat?ggt?tat?gac?gtt?cgc?ggt?gaa?gtc?ttc 835

Ala?Ser?Phe?Ser?Ala?Ala?Tyr?Gly?Tyr?Asp?Val?Arg?Gly?Glu?Val?Phe

230 235 240 245

gga?tcc?aag?ggc?atg?atg?acc?gca?ggc?gac?gcg?cgc?gca?acc?aac?atg 883

Gly?Ser?Lys?Gly?Met?Met?Thr?Ala?Gly?Asp?Ala?Arg?Ala?Thr?Asn?Met

250 255 260

act?ttc?tac?ggc?gct?gag?ggc?atc?gcg?gct?gcc?acc?tca?cgc?gcg?gat 931

Thr?Phe?Tyr?Gly?Ala?Glu?Gly?Ile?Ala?Ala?Ala?Thr?Ser?Arg?Ala?Asp

265 270 275

acc?gat?ctg?ctc?tcc?gat?gct?tac?cga?gct?gaa?ttc?caa?gct?ttc?gtc 979

Thr?Asp?Leu?Leu?Ser?Asp?Ala?Tyr?Arg?Ala?Glu?Phe?Gln?Ala?Phe?Val

280 285 290

gac?tcc?atc?cgt?acc?aac?acc?cct?tcc?aag?gtt?cca?ggc?gaa?gct?gca 1027

Asp?Ser?Ile?Arg?Thr?Asn?Thr?Pro?Ser?Lys?Val?Pro?Gly?Glu?Ala?Ala

295 300 305

cgc?acc?gca?cta?ctc?atc?gca?ctc?ggc?gcc?atc?cga?agc?gta?gaa?acc 1075

Arg?Thr?Ala?Leu?Leu?Ile?Ala?Leu?Gly?Ala?Ile?Arg?Ser?Val?Glu?Thr

310 315 320 325

ggc?gca?acc?atc?aac?ctt?gct?gaa?agc?atc?gag?gtt?taaccatgac 1121

Gly?Ala?Thr?Ile?Asn?Leu?Ala?Glu?Ser?Ile?Glu?Val

330 335

ttttaaactc?gca 1134

<210>288

<211>337

<212>PRT

＜213〉Corynebacterium glutamicum

<400>288

Met?Ser?Val?Lys?Leu?Ala?Leu?Ile?Gly?Ala?Gly?Arg?Ile?Gly?Ser?Asn

1 5 10 15

His?Ala?Arg?Leu?Ile?Thr?Asn?His?Val?Ile?Gly?Ser?Glu?Leu?Val?Ala

20 25 30

Val?Val?Asp?Pro?Thr?Pro?Ash?Ala?Glu?Thr?Leu?Ala?Asp?Glu?Leu?Gly

35 40 45

Ala?Val?Ala?Phe?Ser?Asn?Pro?Asp?Asp?Val?Leu?Thr?Arg?Asp?Asp?Ile

50 55 60

Asp?Ala?Val?Leu?Ile?Ala?Thr?Pro?Ala?Arg?Thr?His?Ala?Asp?Leu?Val

65 70 75 80

Val?Lys?Ala?Ala?Ala?Ala?Gly?Lys?His?Val?Phe?Val?Glu?Lys?Pro?Met

85 90 95

Ala?Val?Thr?Leu?Glu?Asp?Ala?Asp?Arg?Ala?Ile?Asn?Ala?Ala?Arg?Glu

100 105 110

Ala?Asn?Thr?Val?Leu?Gln?Val?Gly?Phe?Asn?Arg?Arg?Phe?Ala?Ala?Gly

115 120 125

Phe?Ala?Ala?Ala?Arg?Ala?Arg?Ile?Asp?Ala?Gly?Asp?Ile?Gly?Thr?Pro

130 135 140

Gln?Leu?Leu?Arg?Ser?Val?Thr?Arg?Asp?Pro?Gly?Pro?Phe?Thr?Ala?Asp

145 150 155 160

Pro?Asn?Lys?Ile?Pro?Gln?Trp?Thr?Ile?Phe?Leu?Glu?Thr?Leu?Ile?His

165 170 175

Asp?Phe?Asp?Ala?Leu?Cys?Tyr?Leu?Asn?Pro?Gly?Ala?Thr?Pro?Val?Glu

180 185 190

Val?Thr?Ala?His?Ala?Asp?Cys?Leu?Val?Val?Pro?Glu?Ala?Ala?Gly?Thr

195 200 205

Gly?Phe?Leu?Asp?Thr?Ala?Val?Val?Thr?Val?Arg?Phe?Asp?Asn?Gly?Ala

210 215 220

Ile?Gly?Thr?Ala?Glu?Ala?Ser?Phe?Ser?Ala?Ala?Tyr?Gly?Tyr?Asp?Val

225 230 235 240

Arg?Gly?Glu?Val?Phe?Gly?Ser?Lys?Gly?Met?Met?Thr?Ala?Gly?Asp?Ala

245 250 255

Arg?Ala?Thr?Asn?Met?Thr?Phe?Tyr?Gly?Ala?Glu?Gly?Ile?Ala?Ala?Ala

260 265 270

Thr?Ser?Arg?Ala?Asp?Thr?Asp?Leu?Leu?Ser?Asp?Ala?Tyr?Arg?Ala?Glu

275 280 285

Phe?Gln?Ala?Phe?Val?Asp?Ser?Ile?Arg?Thr?Asn?Thr?Pro?Ser?Lys?Val

290 295 300

Pro?Gly?Glu?Ala?Ala?Arg?Thr?Ala?Leu?Leu?Ile?Ala?Leu?Gly?Ala?Ile

305 310 315 320

Arg?Ser?Val?Glu?Thr?Gly?Ala?Thr?Ile?Asn?Leu?Ala?Glu?Ser?Ile?Glu

325 330 335

Val

<210>289

<211>996

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(973)

<223>RXN00013

<400>289

ctgcagaaaa?ttcgggacgc?atgattgcac?atattacccg?caccgattgt?gattcttaga?60

acgccacctt?attcagcaca?cttggccgac?ggcatgcaca?atg?gaa?ggc?atg?act 115

Met?Glu?Gly?Met?Thr

1 5

aat?cca?gag?cag?aca?cat?ccc?gct?gca?agc?ctc?gaa?gac?atg?atc?aaa 163

Asn?Pro?Glu?Gln?Thr?His?Pro?Ala?Ala?Ser?Leu?Glu?Asp?Met?Ile?Lys

10 15 20

acc?atc?aca?aag?acc?ttc?gtg?att?gct?cac?gat?cag?gat?tct?gat?gag 211

Thr?Ile?Thr?Lys?Thr?Phe?Val?Ile?Ala?His?Asp?Gln?Asp?Ser?Asp?Glu

25 30 35

cat?ctt?gcg?cag?gca?ctg?gtg?tac?aac?gct?gga?cgt?ttg?gca?tgg?cgc 259

His?Leu?Ala?Gln?Ala?Leu?Val?Tyr?Asn?Ala?Gly?Arg?Leu?Ala?Trp?Arg

40 45 50

atg?cgc?gaa?aac?ggt?gtg?gat?acg?gat?tac?aag?act?tct?gtg?tct?gat 307

Met?Arg?Glu?Asn?Gly?Val?Asp?Thr?Asp?Tyr?Lys?Thr?Ser?Val?Ser?Asp

55 60 65

gtg?gtc?acg?gat?gcc?gat?cgt?gcg?gcc?gag?gcc?ttc?gtc?gca?ggc?gtt 355

Val?Val?Thr?Asp?Ala?Asp?Arg?Ala?Ala?Glu?Ala?Phe?Val?Ala?Gly?Val

70 75 80 85

ctt?gaa?gcg?ttg?cgg?cct?gag?gac?ggc?gtg?ctt?ggc?gag?gaa?ggc?gcg 403

Leu?Glu?Ala?Leu?Arg?Pro?Glu?Asp?Gly?Val?Leu?Gly?Glu?Glu?Gly?Ala

90 95 100

gac?cgg?gcg?tcg?aaa?agc?gga?aaa?acc?tgg?gtc?atc?gac?ccg?gtt?gat 451

Asp?Arg?Ala?Ser?Lys?Ser?Gly?Lys?Thr?Trp?Val?Ile?Asp?Pro?Val?Asp

105 110 115

ggc?acc?tac?aac?ttc?acc?cag?ggc?tca?gat?tat?tgg?tgc?tcg?gcg?ctc 499

Gly?Thr?Tyr?Asn?Phe?Thr?Gln?Gly?Ser?Asp?Tyr?Trp?Cys?Ser?Ala?Leu

120 125 130

gcg?ctg?gtc?gag?ggc?gat?cca?tcc?gcg?cca?tcg?cgc?gtg?ctt?ttc?ggc 547

Ala?Leu?Val?Glu?Gly?Asp?Pro?Ser?Ala?Pro?Ser?Arg?Val?Leu?Phe?Gly

135 140 145

gcc?gta?cac?cgc?cca?gcc?atg?ggt?tat?acg?tgg?ttc?ggt?ggc?ccg?gga 595

Ala?Val?His?Arg?Pro?Ala?Met?Gly?Tyr?Thr?Trp?Phe?Gly?Gly?Pro?Gly

150 155 160 165

atc?cgc?acc?acg?ctc?gac?ggc?aag?gag?cta?gat?ttg?ctt?gtc?gac?gcc 643

Ile?Arg?Thr?Thr?Leu?Asp?Gly?Lys?Glu?Leu?Asp?Leu?Leu?Val?Asp?Ala

170 175 180

ccc?ctc?aat?caa?atc?tcc?ctg?gcc?acc?tac?atc?cac?ccg?tca?cgc?atc 691

Pro?Leu?Asn?Gln?Ile?Ser?Leu?Ala?Thr?Tyr?Ile?His?Pro?Ser?Arg?Ile

185 190 195

gcg?gaa?cct?gat?att?caa?aag?gcg?tgg?atg?agc?gtt?gcc?acc?cac?cct 739

Ala?Glu?Pro?Asp?Ile?Gln?Lys?Ala?Trp?Met?Ser?Val?Ala?Thr?His?Pro

200 205 210

gca?acg?ctg?cgc?atg?ttc?ggc?gcc?ggc?tcc?atc?gat?ttg?gcc?aac?atc 787

Ala?Thr?Leu?Arg?Met?Phe?Gly?Ala?Gly?Ser?Ile?Asp?Leu?Ala?Asn?Ile

215 220 225

gcc?gac?ggc?agc?atg?ggc?gca?tgg?gtg?cag?cac?agc?gtc?gca?gat?tgg 835

Ala?Asp?Gly?Ser?Met?Gly?Ala?Trp?Val?Gln?His?Ser?Val?Ala?Asp?Trp

230 235 240 245

gac?tgg?cta?ccc?ggc?cgc?gca?ctc?atc?gaa?ggc?gtc?ggc?gga?gca?tgc 883

Asp?Trp?Leu?Pro?Gly?Arg?Ala?Leu?Ile?Glu?Gly?Val?Gly?Gly?Ala?Cys

250 255 260

atc?aaa?gtg?acc?gcc?ggc?ggc?gtc?gaa?tgg?tcc?gtt?gca?gga?aac?gcg 931

Ile?Lys?Val?Thr?Ala?Gly?Gly?Val?Glu?Trp?Ser?Val?Ala?Gly?Asn?Ala

265 270 275

gaa?gca?gtt?agt?gag?atc?tcc?gaa?act?tta?agc?gca?cta?gac 973

Glu?Ala?Val?Ser?Glu?Ile?Ser?Glu?Thr?Leu?Ser?Ala?Leu?Asp

280 285 290

taacaacaca?tgagcaaata?tgc 996

<210>290

<211>291

<212>PRT

＜213〉Corynebacterium glutamicum

<400>290

Met?Glu?Gly?Met?Thr?Asn?Pro?Glu?Gln?Thr?His?Pro?Ala?Ala?Ser?Leu

1 5 10 15

Glu?Asp?Met?Ile?Lys?Thr?Ile?Thr?Lys?Thr?Phe?Val?Ile?Ala?His?Asp

20 25 30

Gln?Asp?Ser?Asp?Glu?His?Leu?Ala?Gln?Ala?Leu?Val?Tyr?Asn?Ala?Gly

35 40 45

Arg?Leu?Ala?Trp?Arg?Met?Arg?Glu?Asn?Gly?Val?Asp?Thr?Asp?Tyr?Lys

50 55 60

Thr?Ser?Val?Ser?Asp?Val?Val?Thr?Asp?Ala?Asp?Arg?Ala?Ala?Glu?Ala

65 70 75 80

Phe?Val?Ala?Gly?Val?Leu?Glu?Ala?Leu?Arg?Pro?Glu?Asp?Gly?Val?Leu

85 90 95

Gly?Glu?Glu?Gly?Ala?Asp?Arg?Ala?Ser?Lys?Ser?Gly?Lys?Thr?Trp?Val

100 105 110

Ile?Asp?Pro?Val?Asp?Gly?Thr?Tyr?Asn?Phe?Thr?Gln?Gly?Ser?Asp?Tyr

115 120 125

Trp?Cys?Ser?Ala?Leu?Ala?Leu?Val?Glu?Gly?Asp?Pro?Ser?Ala?Pro?Ser

130 135 140

Arg?Val?Leu?Phe?Gly?Ala?Val?His?Arg?Pro?Ala?Met?Gly?Tyr?Thr?Trp

145 150 155 160

Phe?Gly?Gly?Pro?Gly?Ile?Arg?Thr?Thr?Leu?Asp?Gly?Lys?Glu?Leu?Asp

165 170 175

Leu?Leu?Val?Asp?Ala?Pro?Leu?Asn?Gln?Ile?Ser?Leu?Ala?Thr?Tyr?Ile

180 185 190

His?Pro?Ser?Arg?Ile?Ala?Glu?Pro?Asp?Ile?Gln?Lys?Ala?Trp?Met?Ser

195 200 205

Val?Ala?Thr?His?Pro?Ala?Thr?Leu?Arg?Met?Phe?Gly?Ala?Gly?Ser?Ile

210 215 220

Asp?Leu?Ala?Asn?Ile?Ala?Asp?Gly?Ser?Met?Gly?Ala?Trp?Val?Gln?His

225 230 235 240

Ser?Val?Ala?Asp?Trp?Asp?Trp?Leu?Pro?Gly?Arg?Ala?Leu?Ile?Glu?Gly

245 250 255

Val?Gly?Gly?Ala?Cys?Ile?Lys?Val?Thr?Ala?Gly?Gly?Val?Glu?Trp?Ser

260 265 270

Val?Ala?Gly?Asn?Ala?Glu?Ala?Val?Ser?Glu?Ile?Ser?Glu?Thr?Leu?Ser

275 280 285

Ala?Leu?Asp

290

<210>291

<211>996

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(973)

<223>FRXA00013

<400>291

ctgcagaaaa?ttcgggacgc?atgattgcac?atattacccg?caccgattgt?gattcttaga?60

acgccacctt?attcagcaca?cttggccgac?ggcatgcaca?atg?gaa?ggc?atg?act 115

Met?Glu?Gly?Met?Thr

1 5

aat?cca?gag?cag?aca?cat?ccc?gct?gca?agc?ctc?gaa?gac?atg?atc?aaa 163

Asn?Pro?Glu?Gln?Thr?His?Pro?Ala?Ala?Ser?Leu?Glu?Asp?Met?Ile?Lys

10 15 20

acc?atc?aca?aag?acc?ttc?gtg?att?gct?cac?gat?cag?gat?tct?gat?gag 211

Thr?Ile?Thr?Lys?Thr?Phe?Val?Ile?Ala?His?Asp?Gln?Asp?Ser?Asp?Glu

25 30 35

cat?ctt?gcg?cag?gca?ctg?gtg?tac?aac?gct?gga?cgt?ttg?gca?tgg?cgc 259

His?Leu?Ala?Gln?Ala?Leu?Val?Tyr?Asn?Ala?Gly?Arg?Leu?Ala?Trp?Arg

40 45 50

atg?cgc?gaa?aac?ggt?gtg?gat?acg?gat?tac?aag?act?tct?gtg?tct?gat 307

Met?Arg?Glu?Asn?Gly?Val?Asp?Thr?Asp?Tyr?Lys?Thr?Ser?Val?Ser?Asp

55 60 65

gtg?gtc?acg?gat?gcc?gat?cgt?gcg?gcc?gag?gcc?ttc?gtc?gca?ggc?gtt 355

Val?Val?Thr?Asp?Ala?Asp?Arg?Ala?Ala?Glu?Ala?Phe?Val?Ala?Gly?Val

70 75 80 85

ctt?gaa?gcg?ttg?cgg?cct?gag?gac?ggc?gtg?ctt?ggc?gag?gaa?ggc?gcg 403

Leu?Glu?Ala?Leu?Arg?Pro?Glu?Asp?Gly?Val?Leu?Gly?Glu?Glu?Gly?Ala

90 95 100

gac?cgg?gcg?tcg?aaa?agc?gga?aaa?acc?tgg?gtc?atc?gac?ccg?gtt?gat 451

Asp?Arg?Ala?Ser?Lys?Ser?Gly?Lys?Thr?Trp?Val?Ile?Asp?Pro?Val?Asp

105 110 115

ggc?acc?tac?aac?ttc?acc?cag?ggc?tca?gat?tat?tgg?tgc?tcg?gcg?ctc 499

Gly?Thr?Tyr?Asn?Phe?Thr?Gln?Gly?Ser?Asp?Tyr?Trp?Cys?Ser?Ala?Leu

120 125 130

gcg?ctg?gtc?gag?ggc?gat?cca?tcc?gcg?cca?tcg?cgc?gtg?ctt?ttc?ggc 547

Ala?Leu?Val?Glu?Gly?Asp?Pro?Ser?Ala?Pro?Ser?Arg?Val?Leu?Phe?Gly

135 140 145

gcc?gta?cac?cgc?cca?gcc?atg?ggt?tat?acg?tgg?ttc?ggt?ggc?ccg?gga 595

Ala?Val?His?Arg?Pro?Ala?Met?Gly?Tyr?Thr?Trp?Phe?Gly?Gly?Pro?Gly

150 155 160 165

atc?cgc?acc?acg?ctc?gac?ggc?aag?gag?cta?gat?ttg?ctt?gtc?gac?gcc 643

Ile?Arg?Thr?Thr?Leu?Asp?Gly?Lys?Glu?Leu?Asp?Leu?Leu?Val?Asp?Ala

170 175 180

ccc?ctc?aat?caa?atc?tcc?ctg?gcc?acc?tac?atc?cac?ccg?tca?cgc?atc 691

Pro?Leu?Asn?Gln?Ile?Ser?Leu?Ala?Thr?Tyr?Ile?His?Pro?Ser?Arg?Ile

185 190 195

gcg?gaa?cct?gat?att?caa?aag?gcg?tgg?atg?agc?gtt?gcc?acc?cac?cct 739

Ala?Glu?Pro?Asp?Ile?Gln?Lys?Ala?Trp?Met?Ser?Val?Ala?Thr?His?Pro

200 205 210

gca?acg?ctg?cgc?atg?ttc?ggc?gcc?ggc?tcc?atc?gat?ttg?gcc?aac?atc 787

Ala?Thr?Leu?Arg?Met?Phe?Gly?Ala?Gly?Ser?Ile?Asp?Leu?Ala?Asn?Ile

215 220 225

gcc?gac?ggc?agc?atg?ggc?gca?tgg?gtg?cag?cac?agc?gtc?gca?gat?tgg 835

Ala?Asp?Gly?Ser?Met?Gly?Ala?Trp?Val?Gln?His?Ser?Val?Ala?Asp?Trp

230 235 240 245

gac?tgg?cta?ccc?ggc?cgc?gca?ctc?atc?gaa?ggc?gtc?ggc?gga?gcg?tgc 883

Asp?Trp?Leu?Pro?Gly?Arg?Ala?Leu?Ile?Glu?Gly?Val?Gly?Gly?Ala?Cys

250 255 260

atc?aaa?gtg?acc?gcc?ggc?ggc?gtc?gaa?tgg?tcc?gtt?gca?gga?aac?gcg 931

Ile?Lys?Val?Thr?Ala?Gly?Gly?Val?Glu?Trp?Ser?Val?Ala?Gly?Asn?Ala

265 270 275

gaa?gca?gtt?agt?gag?atc?tcc?gaa?act?tta?agc?gca?cta?gac 973

Glu?Ala?Val?Ser?Glu?Ile?Ser?Glu?Thr?Leu?Ser?Ala?Leu?Asp

280 285 290

tagcaacaca?tgagcaaata?tgc 996

<210>292

<211>291

<212>PRT

＜213〉Corynebacterium glutamicum

<400>292

Met?Glu?Gly?Met?Thr?Asn?Pro?Glu?Gln?Thr?His?Pro?Ala?Ala?Ser?Leu

1 5 10 15

Glu?Asp?Met?Ile?Lys?Thr?Ile?Thr?Lys?Thr?Phe?Val?Ile?Ala?His?Asp

20 25 30

Gln?Asp?Ser?Asp?Glu?His?Leu?Ala?Gln?Ala?Leu?Val?Tyr?Asn?Ala?Gly

35 40 45

Arg?Leu?Ala?Trp?Arg?Met?Arg?Glu?Asn?Gly?Val?Asp?Thr?Asp?Tyr?Lys

50 55 60

Thr?Ser?Val?Ser?Asp?Val?Val?Thr?Asp?Ala?Asp?Arg?Ala?Ala?Glu?Ala

65 70 75 80

Phe?Val?Ala?Gly?Val?Leu?Glu?Ala?Leu?Arg?Pro?Glu?Asp?Gly?Val?Leu

85 90 95

Gly?Glu?Glu?Gly?Ala?Asp?Arg?Ala?Ser?Lys?Ser?Gly?Lys?Thr?Trp?Val

100 105 110

Ile?Asp?Pro?Val?Asp?Gly?Thr?Tyr?Asn?Phe?Thr?Gln?Gly?Ser?Asp?Tyr

115 120 125

Trp?Cys?Ser?Ala?Leu?Ala?Leu?Val?Glu?Gly?Asp?Pro?Ser?Ala?Pro?Ser

130 135 140

Arg?Val?Leu?Phe?Gly?Ala?Val?His?Arg?Pro?Ala?Met?Gly?Tyr?Thr?Trp

145 150 155 160

Phe?Gly?Gly?Pro?Gly?Ile?Arg?Thr?Thr?Leu?Asp?Gly?Lys?Glu?Leu?Asp

165 170 175

Leu?Leu?Val?Asp?Ala?Pro?Leu?Asn?Gln?Ile?Ser?Leu?Ala?Thr?Tyr?Ile

180 185 190

His?Pro?Ser?Arg?Ile?Ala?Glu?Pro?Asp?Ile?Gln?Lys?Ala?Trp?Met?Ser

195 200 205

Val?Ala?Thr?His?Pro?Ala?Thr?Leu?Arg?Met?Phe?Gly?Ala?Gly?Ser?Ile

210 215 220

Asp?Leu?Ala?Asn?Ile?Ala?Asp?Gly?Ser?Met?Gly?Ala?Trp?Val?Gln?His

225 230 235 240

Ser?Val?Ala?Asp?Trp?Asp?Trp?Leu?Pro?Gly?Arg?Ala?Leu?Ile?Glu?Gly

245 250 255

Val?Gly?Gly?Ala?Cys?Ile?Lys?Val?Thr?Ala?Gly?Gly?Val?Glu?Trp?Ser

260 265 270

Val?Ala?Gly?Asn?Ala?Glu?Ala?Val?Ser?Glu?Ile?Ser?Glu?Thr?Leu?Ser

275 280 285

Ala?Leu?Asp

290

<210>293

<211>948

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(925)

<223>RXA01099

<400>293

ggatgagggc?attgattccg?tcatcattgg?caaggcactt?tatgagcaca?agttcaccct?60

cgaagaggct?ttggctgcag?tagaaaagct?cggttaatac?atg?gat?gct?cgt?ggg 115

Met?Asp?Ala?Arg?Gly

1 5

atg?ttg?gcc?att?gcg?gag?gcc?gtt?gta?gat?gat?gcc?gaa?gcc?ctc?ttc 163

Met?Leu?Ala?Ile?Ala?Glu?Ala?Val?Val?Asp?Asp?Ala?Glu?Ala?Leu?Phe

10 15 20

atg?cag?ggc?ttc?gga?gct?gca?cct?gcc?cat?atg?aaa?tcc?ccg?ggg?gat 211

Met?Gln?Gly?Phe?Gly?Ala?Ala?Pro?Ala?His?Met?Lys?Ser?Pro?Gly?Asp

25 30 35

ttt?gcc?acg?gaa?gtg?gat?atg?gcc?atc?gaa?tcc?cat?atg?cgt?tcg?atg 259

Phe?Ala?Thr?Glu?Val?Asp?Met?Ala?Ile?Glu?Ser?His?Met?Arg?Ser?Met

40 45 50

ctg?aac?atg?atg?aca?ggc?att?gct?gtc?atc?ggt?gaa?gaa?ggt?ggc?ggt 307

Leu?Asn?Met?Met?Thr?Gly?Ile?Ala?Val?Ile?Gly?Glu?Glu?Gly?Gly?Gly

55 60 65

gcg?acc?tcc?ggc?acg?cgc?tgg?gtg?att?gat?ccc?atc?gac?ggc?acc?gcc 355

Ala?Thr?Ser?Gly?Thr?Arg?Trp?Val?Ile?Asp?Pro?Ile?Asp?Gly?Thr?Ala

70 75 80 85

aac?ttc?gcg?gcg?tcc?aac?ccg?atg?agc?gcg?atc?ctg?gtg?tct?ttg?ctt 403

Asn?Phe?Ala?Ala?Ser?Asn?Pro?Met?Ser?Ala?Ile?Leu?Val?Ser?Leu?Leu

90 95 100

gtc?gac?gac?cag?ccc?gtc?ctg?ggt?att?acc?tcc?atg?ccc?atg?ctg?ggt 451

Val?Asp?Asp?Gln?Pro?Val?Leu?Gly?Ile?Thr?Ser?Met?Pro?Met?Leu?Gly

105 110 115

aaa?cgc?ctc?acc?gct?ttt?gaa?ggt?tca?ccg?ctg?atg?atc?aac?ggt?gaa 499

Lys?Arg?Leu?Thr?Ala?Phe?Glu?Gly?Ser?Pro?Leu?Met?Ile?Asn?Gly?Glu

120 125 130

cct?cag?gaa?cca?ttg?caa?gaa?caa?tcc?agt?ttg?gta?tcc?cac?att?ggt 547

Pro?Gln?Glu?Pro?Leu?Gln?Glu?Gln?Ser?Ser?Leu?Val?Ser?His?Ile?Gly

135 140 145

ttt?agt?tcc?atg?gcc?tcc?ccg?cgc?aat?aca?gcg?ttt?cct?gtg?gag?ttg 595

Phe?Ser?Ser?Met?Ala?Ser?Pro?Arg?Asn?Thr?Ala?Phe?Pro?Val?Glu?Leu

150 155 160 165

cgt?cgg?gat?ctt?ctg?acc?gag?ctc?acg?gaa?tcg?tat?ctt?cgt?ccc?cgc 643

Arg?Arg?Asp?Leu?Leu?Thr?Glu?Leu?Thr?Glu?Ser?Tyr?Leu?Arg?Pro?Arg

170 175 180

att?aca?ggt?tcg?gtg?ggt?gtt?gat?ctc?gcg?ttc?act?gcg?cag?ggc?att 691

Ile?Thr?Gly?Ser?Val?Gly?Val?Asp?Leu?Ala?Phe?Thr?Ala?Gln?Gly?Ile

185 190 195

ttt?gga?gca?tgc?gta?tcg?ttt?agt?cct?cat?gtt?tgg?gac?aat?tcc?gca 739

Phe?Gly?Ala?Cys?Val?Ser?Phe?Ser?Pro?His?Val?Trp?Asp?Asn?Ser?Ala

200 205 210

ggc?gtg?atg?ttg?atg?cgc?gct?gct?ggt?gca?caa?gtt?act?gac?acc?gaa 787

Gly?Val?Met?Leu?Met?Arg?Ala?Ala?Gly?Ala?Gln?Val?Thr?Asp?Thr?Glu

215 220 225

ggc?cat?ccg?tgg?gca?cca?ggt?agg?gga?gtc?gtg?gcc?gga?aca?aaa?agg 835

Gly?His?Pro?Trp?Ala?Pro?Gly?Arg?Gly?Val?Val?Ala?Gly?Thr?Lys?Arg

230 235 240 245

gct?cac?gat?gtg?ctg?tta?agt?aag?att?gaa?aaa?gtt?cgg?ttg?atg?cat 883

Ala?His?Asp?Val?Leu?Leu?Ser?Lys?Ile?Glu?Lys?Val?Arg?Leu?Met?His

250 255 260

gca?gat?gca?ggt?aat?gac?cag?tcg?tta?aat?gag?gag?tac?aag 925

Ala?Asp?Ala?Gly?Asn?Asp?Gln?Ser?Leu?Asn?Glu?Glu?Tyr?Lys

265 270 275

taaaatgggc?gtggcaattc?gag 948

<210>294

<211>275

<212>PRT

＜213〉Corynebacterium glutamicum

<400>294

Met?Asp?Ala?Arg?Gly?Met?Leu?Ala?Ile?Ala?Glu?Ala?Val?Val?Asp?Asp

1 5 10 15

Ala?Glu?Ala?Leu?Phe?Met?Gln?Gly?Phe?Gly?Ala?Ala?Pro?Ala?His?Met

20 25 30

Lys?Ser?Pro?Gly?Asp?Phe?Ala?Thr?Glu?Val?Asp?Met?Ala?Ile?Glu?Ser

35 40 45

His?Met?Arg?Ser?Met?Leu?Asn?Met?Met?Thr?Gly?Ile?Ala?Val?Ile?Gly

50 55 60

Glu?Glu?Gly?Gly?Gly?Ala?Thr?Ser?Gly?Thr?Arg?Trp?Val?Ile?Asp?Pro

65 70 75 80

Ile?Asp?Gly?Thr?Ala?Asn?Phe?Ala?Ala?Ser?Asn?Pro?Met?Ser?Ala?Ile

85 90 95

Leu?Val?Ser?Leu?Leu?Val?Asp?Asp?Gln?Pro?Val?Leu?Gly?Ile?Thr?Ser

100 105 110

Met?Pro?Met?Leu?Gly?Lys?Arg?Leu?Thr?Ala?Phe?Glu?Gly?Ser?Pro?Leu

115 120 125

Met?Ile?Asn?Gly?Glu?Pro?Gln?Glu?Pro?Leu?Gln?Glu?Gln?Ser?Ser?Leu

130 135 140

Val?Ser?His?Ile?Gly?Phe?Ser?Ser?Met?Ala?Ser?Pro?Arg?Asn?Thr?Ala

145 150 155 160

Phe?Pro?Val?Glu?Leu?Arg?Arg?Asp?Leu?Leu?Thr?Glu?Leu?Thr?Glu?Ser

165 170 175

Tyr?Leu?Arg?Pro?Arg?Ile?Thr?Gly?Ser?Val?Gly?Val?Asp?Leu?Ala?Phe

180 185 190

Thr?Ala?Gln?Gly?Ile?Phe?Gly?Ala?Cys?Val?Ser?Phe?Ser?Pro?His?Val

195 200 205

Trp?Asp?Asn?Ser?Ala?Gly?Val?Met?Leu?Met?Arg?Ala?Ala?Gly?Ala?Gln

210 215 220

Val?Thr?Asp?Thr?Glu?Gly?His?Pro?Trp?Ala?Pro?Gly?Arg?Gly?Val?Val

225 230 235 240

Ala?Gly?Thr?Lys?Arg?Ala?His?Asp?Val?Leu?Leu?Ser?Lys?Ile?Glu?Lys

245 250 255

Val?Arg?Leu?Met?His?Ala?Asp?Ala?Gly?Asn?Asp?Gln?Ser?Leu?Asn?Glu

260 265 270

Glu?Tyr?Lys

275

<210>295

<211>576

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(576)

<223>RXN01332

<400>295

cac?atc?tct?gcc?att?att?gag?ccc?gac?gca?gca?cgt?gcc?gct?gca?gct 48

His?Ile?Ser?Ala?Ile?Ile?Glu?Pro?Asp?Ala?Ala?Arg?Ala?Ala?Ala?Ala

1 5 10 15

gca?gaa?gac?gcg?ccg?ggt?gca?cag?gcc?ttc?act?cgc?att?gaa?gat?gct 96

Ala?Glu?Asp?Ala?Pro?Gly?Ala?Gln?Ala?Phe?Thr?Arg?Ile?Glu?Asp?Ala

20 25 30

atc?gca?gcc?gat?gct?gtc?gac?gca?gtg?ctg?atc?gcc?gta?cca?ggt?cag 144

Ile?Ala?Ala?Asp?Ala?Val?Asp?Ala?Val?Leu?Ile?Ala?Val?Pro?Gly?Gln

35 40 45

ttc?cat?gag?cca?gta?ctt?gtc?cca?gca?cta?gaa?gca?ggc?ctt?ccc?atc 192

Phe?His?Glu?Pro?Val?Leu?Val?Pro?Ala?Leu?Glu?Ala?Gly?Leu?Pro?Ile

50 55 60

ctg?tgt?gaa?aag?cca?ctg?acc?cca?gat?tct?gaa?tcc?tca?ctg?cgc?atc 240

Leu?Cys?Glu?Lys?Pro?Leu?Thr?Pro?Asp?Ser?Glu?Ser?Ser?Leu?Arg?Ile

65 70 75 80

gtc?gag?ctg?gag?cag?aag?ctg?gac?aag?cca?cac?atc?cag?gtt?ggt?ttc 288

Val?Glu?Leu?Glu?Gln?Lys?Leu?Asp?Lys?Pro?His?Ile?Gln?Val?Gly?Phe

85 90 95

atg?cgc?cgc?ttc?gac?cct?gag?tac?aac?aac?ttg?cgc?aaa?ttg?gtg?gaa 336

Met?Arg?Arg?Phe?Asp?Pro?Glu?Tyr?Asn?Asn?Leu?Arg?Lys?Leu?Val?Glu

100 105 110

tcc?ggc?gaa?gct?ggc?gaa?ctg?ctc?atg?ctc?cgc?ggc?ctg?cac?cgc?aac 384

Ser?Gly?Glu?Ala?Gly?Glu?Leu?Leu?Met?Leu?Arg?Gly?Leu?His?Arg?Asn

115 120 125

cca?agt?gtt?ggt?gag?agc?tac?acc?cag?tcc?atg?ctg?atc?acc?gac?tcc 432

Pro?Ser?Val?Gly?Glu?Ser?Tyr?Thr?Gln?Ser?Met?Leu?Ile?Thr?Asp?Ser

130 135 140

gtc?gtc?cac?gaa?ttc?gat?gtc?atc?cca?tgg?ctc?gca?ggc?tcc?cga?gtt 480

Val?Val?His?Glu?Phe?Asp?Val?Ile?Pro?Trp?Leu?Ala?Gly?Ser?Arg?Val

145 150 155 160

gtc?tcc?gtt?gaa?gtg?aag?tac?cca?aag?acc?tcc?tca?ctg?gcg?cac?tcc 528

Val?Ser?Val?Glu?Val?Lys?Tyr?Pro?Lys?Thr?Ser?Ser?Leu?Ala?His?Ser

165 170 175

ggc?ctc?aag?gaa?cca?atc?ctg?gtg?atc?atg?gag?ctc?gaa?aac?ggc?gtg 576

Gly?Leu?Lys?Glu?Pro?Ile?Leu?Val?Ile?Met?Glu?Leu?Glu?Asn?Gly?Val

180 185 190

<210>296

<211>192

<212>PRT

＜213〉Corynebacterium glutamicum

<400>296

His?Ile?Ser?Ala?Ile?Ile?Glu?Pro?Asp?Ala?Ala?Arg?Ala?Ala?Ala?Ala

1 5 10 15

Ala?Glu?Asp?Ala?Pro?Gly?Ala?Gln?Ala?Phe?Thr?Arg?Ile?Glu?Asp?Ala

20 25 30

Ile?Ala?Ala?Asp?Ala?Val?Asp?Ala?Val?Leu?Ile?Ala?Val?Pro?Gly?Gln

35 40 45

Phe?His?Glu?Pro?Val?Leu?Val?Pro?Ala?Leu?Glu?Ala?Gly?Leu?Pro?Ile

50 55 60

Leu?Cys?Glu?Lys?Pro?Leu?Thr?Pro?Asp?Ser?Glu?Ser?Ser?Leu?Arg?Ile

65 70 75 80

Val?Glu?Leu?Glu?Gln?Lys?Leu?Asp?Lys?Pro?His?Ile?Gln?Val?Gly?Phe

85 90 95

Met?Arg?Arg?Phe?Asp?Pro?Glu?Tyr?Asn?Asn?Leu?Arg?Lys?Leu?Val?Glu

100 105 110

Ser?Gly?Glu?Ala?Gly?Glu?Leu?Leu?Met?Leu?Arg?Gly?Leu?His?Arg?Asn

115 120 125

Pro?Ser?Val?Gly?Glu?Ser?Tyr?Thr?Gln?Ser?Met?Leu?Ile?Thr?Asp?Ser

130 135 140

Val?Val?His?Glu?Phe?Asp?Val?Ile?Pro?Trp?Leu?Ala?Gly?Ser?Arg?Val

145 150 155 160

Val?Ser?Val?Glu?Val?Lys?Tyr?Pro?Lys?Thr?Ser?Ser?Leu?Ala?His?Ser

165 170 175

Gly?Leu?Lys?Glu?Pro?Ile?Leu?Val?Ile?Met?Glu?Leu?Glu?Asn?Gly?Val

180 185 190

<210>297

<211>549

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(549)

<223>FRXA01332

<400>297

gca?gca?cgt?gcc?gct?gca?gct?gca?gaa?gac?gcg?ccg?ggt?gca?cag?gcc 48

Ala?Ala?Arg?Ala?Ala?Ala?Ala?Ala?Glu?Asp?Ala?Pro?Gly?Ala?Gln?Ala

1 5 10 15

ttc?act?cgc?att?gaa?gat?gct?atc?gca?gcc?gat?gct?gtc?gac?gca?gtg 96

Phe?Thr?Arg?Ile?Glu?Asp?Ala?Ile?Ala?Ala?Asp?Ala?Val?Asp?Ala?Val

20 25 30

ctg?atc?gcc?gta?cca?ggt?cag?ttc?cat?gag?cca?gta?ctt?gtc?cca?gca 144

Leu?Ile?Ala?Val?Pro?Gly?Gln?Phe?His?Glu?Pro?Val?Leu?Val?Pro?Ala

35 40 45

cta?gaa?gca?ggc?ctt?ccc?atc?ctg?tgt?gaa?aag?cca?ctg?acc?cca?gat 192

Leu?Glu?Ala?Gly?Leu?Pro?Ile?Leu?Cys?Glu?Lys?Pro?Leu?Thr?Pro?Asp

50 55 60

tct?gaa?tcc?tca?ctg?cgc?atc?gtc?gag?ctg?gag?cag?aag?ctg?gac?aag 240

Ser?Glu?Ser?Ser?Leu?Arg?Ile?Val?Glu?Leu?Glu?Gln?Lys?Leu?Asp?Lys

65 70 75 80

cca?cac?atc?cag?gtt?ggt?ttc?atg?cgc?cgc?ttc?gac?cct?gag?tac?aac 288

Pro?His?Ile?Gln?Val?Gly?Phe?Met?Arg?Arg?Phe?Asp?Pro?Glu?Tyr?Asn

85 90 95

aac?ttg?cgc?aaa?ttg?gtg?gaa?tcc?ggc?gaa?gct?ggc?gaa?ctg?ctc?atg 336

Asn?Leu?Arg?Lys?Leu?Val?Glu?Ser?Gly?Glu?Ala?Gly?Glu?Leu?Leu?Met

100 105 110

ctc?cgc?ggc?ctg?cac?cgc?aac?cca?agt?gtt?ggt?gag?agc?tac?acc?cag 384

Leu?Arg?Gly?Leu?His?Arg?Asn?Pro?Ser?Val?Gly?Glu?Ser?Tyr?Thr?Gln

115 120 125

tcc?atg?ctg?atc?acc?gac?tcc?gtc?gtc?cac?gaa?ttc?gat?gtc?atc?cca 432

Ser?Met?Leu?Ile?Thr?Asp?Ser?Val?Val?His?Glu?Phe?Asp?Val?Ile?Pro

130 135 140

tgg?ctc?gca?ggc?tcc?cga?gtt?gtc?tcc?gtt?gaa?gtg?aag?tac?cca?aag 480

Trp?Leu?Ala?Gly?Ser?Arg?Val?Val?Ser?Val?Glu?Val?Lys?Tyr?Pro?Lys

145 150 155 160

acc?tcc?tca?ctg?gcg?cac?tcc?ggc?ctc?aag?gaa?cca?atc?ctg?gtg?atc 528

Thr?Ser?Ser?Leu?Ala?His?Ser?Gly?Leu?Lys?Glu?Pro?Ile?Leu?Val?Ile

165 170 175

atg?gag?ctc?gaa?aac?ggc?gtg 549

Met?Glu?Leu?Glu?Asn?Gly?Val

180

<210>298

<211>183

<212>PRT

＜213〉Corynebacterium glutamicum

<400>298

Ala?Ala?Arg?Ala?Ala?Ala?Ala?Ala?Glu?Asp?Ala?Pro?Gly?Ala?Gln?Ala

1 5 10 15

Phe?Thr?Arg?Ile?Glu?Asp?Ala?Ile?Ala?Ala?Asp?Ala?Val?Asp?Ala?Val

20 25 30

Leu?Ile?Ala?Val?Pro?Gly?Gln?Phe?His?Glu?Pro?Val?Leu?Val?Pro?Ala

35 40 45

Leu?Glu?Ala?Gly?Leu?Pro?Ile?Leu?Cys?Glu?Lys?Pro?Leu?Thr?Pro?Asp

50 55 60

Ser?Glu?Ser?Ser?Leu?Arg?Ile?Val?Glu?Leu?Glu?Gln?Lys?Leu?Asp?Lys

65 70 75 80

Pro?His?Ile?Gln?Val?Gly?Phe?Met?Arg?Arg?Phe?Asp?Pro?Glu?Tyr?Asn

85 90 95

Asn?Leu?Arg?Lys?Leu?Val?Glu?Ser?Gly?Glu?Ala?Gly?Glu?Leu?Leu?Met

100 105 110

Leu?Arg?Gly?Leu?His?Arg?Asn?Pro?Ser?Val?Gly?Glu?Ser?Tyr?Thr?Gln

115 120 125

Ser?Met?Leu?Ile?Thr?Asp?Ser?Val?Val?His?Glu?Phe?Asp?Val?Ile?Pro

130 135 140

Trp?Leu?Ala?Gly?Ser?Arg?Val?Val?Ser?Val?Glu?Val?Lys?Tyr?Pro?Lys

145 150 155 160

Thr?Ser?Ser?Leu?Ala?His?Ser?Gly?Leu?Lys?Glu?Pro?Ile?Leu?Val?Ile

165 170 175

Met?Glu?Leu?Glu?Asn?Gly?Val

180

<210>299

<211>1128

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1105)

<223>RXA01632

<400>299

aagggctgca?acgtgctttc?gacaccacca?tcgcagcgtt?tgaacaagct?gctcgtctcg?60

ccccctccac?taactgatct?ttgaaaggct?gaaaaaactc?atg?act?ctt?cgt?atc 115

Met?Thr?Leu?Arg?Ile

1 5

gcc?ctt?ttc?ggc?gct?ggc?cgc?atc?ggt?cac?gtc?cac?gct?gcc?aac?att 163

Ala?Leu?Phe?Gly?Ala?Gly?Arg?Ile?Gly?His?Val?His?Ala?Ala?Asn?Ile

10 15 20

gct?gca?aac?cct?gat?ctt?gaa?ctc?gtt?gtt?atc?gcc?gat?cct?ttc?att 211

Ala?Ala?Asn?Pro?Asp?Leu?Glu?Leu?Val?Val?Ile?Ala?Asp?Pro?Phe?Ile

25 30 35

gaa?ggc?gca?cag?cgt?ttg?gca?gaa?gcc?aat?ggg?gca?gaa?gcg?gtt?gca 259

Glu?Gly?Ala?Gln?Arg?Leu?Ala?Glu?Ala?Asn?Gly?Ala?Glu?Ala?Val?Ala

40 45 50

tca?cca?gat?gag?gtg?ttc?gcc?cgc?gat?gat?atc?gat?ggc?atc?gtg?atc 307

Ser?Pro?Asp?Glu?Val?Phe?Ala?Arg?Asp?Asp?Ile?Asp?Gly?Ile?Val?Ile

55 60 65

ggt?tca?cca?acc?agc?acc?cac?gtt?gat?ctg?atc?acc?cgc?gcc?gtg?gaa 355

Gly?Ser?Pro?Thr?Ser?Thr?His?Val?Asp?Leu?Ile?Thr?Arg?Ala?Val?Glu

70 75 80 85

cgt?ggc?att?cct?gca?ctg?tgc?gaa?aaa?ccc?att?gat?tta?gac?att?gaa 403

Arg?Gly?Ile?Pro?Ala?Leu?Cys?Glu?Lys?Pro?Ile?Asp?Leu?Asp?Ile?Glu

90 95 100

atg?gtg?cgt?gcc?tgc?aaa?gag?aag?atc?ggc?gac?ggc?gct?tcc?aag?gtg 451

Met?Val?Arg?Ala?Cys?Lys?Glu?Lys?Ile?Gly?Asp?Gly?Ala?Ser?Lys?Val

105 110 115

atg?ctg?ggg?ttt?aac?cga?cgc?ttc?gat?cct?tct?ttc?gct?gcc?atc?aat 499

Met?Leu?Gly?Phe?Asn?Arg?Arg?Phe?Asp?Pro?Ser?Phe?Ala?Ala?Ile?Asn

120 125 130

gcg?cga?gtg?gca?aac?cag?gag?atc?ggc?aac?ctg?gag?cag?ttg?gtg?atc 547

Ala?Arg?Val?Ala?Asn?Gln?Glu?Ile?Gly?Asn?Leu?Glu?Gln?Leu?Val?Ile

135 140 145

atc?agc?cgc?gat?cca?gcg?ccc?gca?ccg?aag?gac?tac?atc?gca?ggt?tcc 595

Ile?Ser?Arg?Asp?Pro?Ala?Pro?Ala?Pro?Lys?Asp?Tyr?Ile?Ala?Gly?Ser

150 155 160 165

ggt?gga?atc?ttc?cgc?gat?atg?acc?atc?cac?gat?ctg?gat?atg?gcg?cgt 643

Gly?Gly?Ile?Phe?Arg?Asp?Met?Thr?Ile?His?Asp?Leu?Asp?Met?Ala?Arg

170 175 180

ttc?ttt?gtg?ccc?aat?atc?gtg?gaa?gtg?act?gca?acc?ggc?gcc?aat?gtt 691

Phe?Phe?Val?Pro?Asn?Ile?Val?Glu?Val?Thr?Ala?Thr?Gly?Ala?Asn?Val

185 190 195

ttc?agc?cag?gaa?atc?gcg?gag?ttc?aat?gac?tac?gac?cag?gtt?atc?gtc 739

Phe?Ser?Gln?Glu?Ile?Ala?Glu?Phe?Asn?Asp?Tyr?Asp?Gln?Val?Ile?Val

200 205 210

acg?ctt?cgt?ggc?tca?aag?ggc?gag?ttg?atc?aac?atc?gtg?aac?tcc?cgc 787

Thr?Leu?Arg?Gly?Ser?Lys?Gly?Glu?Leu?Ile?Asn?Ile?Val?Asn?Ser?Arg

215 220 225

cac?tgc?tcc?tac?ggc?tac?gac?cag?cga?ctt?gag?gct?ttc?ggc?tct?aag 835

His?Cys?Ser?Tyr?Gly?Tyr?Asp?Gln?Arg?Leu?Glu?Ala?Phe?Gly?Ser?Lys

230 235 240 245

ggc?atg?ctc?gcc?gcc?gac?aac?atc?agg?ccc?acc?acg?gtg?cgc?aag?cac 883

Gly?Met?Leu?Ala?Ala?Asp?Asn?Ile?Arg?Pro?Thr?Thr?Val?Arg?Lys?His

250 255 260

aat?gcg?gaa?agc?acc?gag?cag?gca?gat?ccg?att?ttc?aac?ttc?ttc?ctc 931

Asn?Ala?Glu?Ser?Thr?Glu?Gln?Ala?Asp?Pro?Ile?Phe?Asn?Phe?Phe?Leu

265 270 275

gag?cgc?tac?gac?gcc?gct?tac?aag?gca?gag?ctc?gca?act?ttt?gct?caa 979

Glu?Arg?Tyr?Asp?Ala?Ala?Tyr?Lys?Ala?Glu?Leu?Ala?Thr?Phe?Ala?Gln

280 285 290

gga?atc?cgc?gac?ggc?caa?ggc?ttc?tca?cca?aac?ttc?gag?gac?ggc?gtc 1027

Gly?Ile?Arg?Asp?Gly?Gln?Gly?Phe?Ser?Pro?Asn?Phe?Glu?Asp?Gly?Val

295 300 305

atc?gcc?ctt?gaa?cta?gcg?aat?gca?tgc?ctt?gaa?tca?gct?caa?acc?ggc 1075

Ile?Ala?Leu?Glu?Leu?Ala?Asn?Ala?Cys?Leu?Glu?Ser?Ala?Gln?Thr?Gly

310 315 320 325

cgc?acc?gtc?acc?ctc?aac?cct?gcc?aac?gtt?tagtcaacgt?ctagttaatg 1125

Arg?Thr?Val?Thr?Leu?Asn?Pro?Ala?Asn?Val

330 335

cct 1128

<210>300

<211>335

<212>PRT

＜213〉Corynebacterium glutamicum

<400>300

Met?Thr?Leu?Arg?Ile?Ala?Leu?Phe?Gly?Ala?Gly?Arg?Ile?Gly?His?Val

1 5 10 15

His?Ala?Ala?Asn?Ile?Ala?Ala?Asn?Pro?Asp?Leu?Glu?Leu?Val?Val?Ile

20 25 30

Ala?Asp?Pro?Phe?Ile?Glu?Gly?Ala?Gln?Arg?Leu?Ala?Glu?Ala?Asn?Gly

35 40 45

Ala?Glu?Ala?Val?Ala?Ser?Pro?Asp?Glu?Val?Phe?Ala?Arg?Asp?Asp?Ile

50 55 60

Asp?Gly?Ile?Val?Ile?Gly?Ser?Pro?Thr?Ser?Thr?His?Val?Asp?Leu?Ile

65 70 75 80

Thr?Arg?Ala?Val?Glu?Arg?Gly?Ile?Pro?Ala?Leu?Cys?Glu?Lys?Pro?Ile

85 90 95

Asp?Leu?Asp?Ile?Glu?Met?Val?Arg?Ala?Cys?Lys?Glu?Lys?Ile?Gly?Asp

100 105 110

Gly?Ala?Ser?Lys?Val?Met?Leu?Gly?Phe?Asn?Arg?Arg?Phe?Asp?Pro?Ser

115 120 125

Phe?Ala?Ala?Ile?Asn?Ala?Arg?Val?Ala?Asn?Gln?Glu?Ile?Gly?Asn?Leu

130 135 140

Glu?Gln?Leu?Val?Ile?Ile?Ser?Arg?Asp?Pro?Ala?Pro?Ala?Pro?Lys?Asp

145 150 155 160

Tyr?Ile?Ala?Gly?Ser?Gly?Gly?Ile?Phe?Arg?Asp?Met?Thr?Ile?His?Asp

165 170 175

Leu?Asp?Met?Ala?Arg?Phe?Phe?Val?Pro?Asn?Ile?Val?Glu?Val?Thr?Ala

180 185 190

Thr?Gly?Ala?Asn?Val?Phe?Ser?Gln?Glu?Ile?Ala?Glu?Phe?Asn?Asp?Tyr

195 200 205

Asp?Gln?Val?Ile?Val?Thr?Leu?Arg?Gly?Ser?Lys?Gly?Glu?Leu?Ile?Asn

210 215 220

Ile?Val?Asn?Ser?Arg?His?Cys?Ser?Tyr?Gly?Tyr?Asp?Gln?Arg?Leu?Glu

225 230 235 240

Ala?Phe?Gly?Ser?Lys?Gly?Met?Leu?Ala?Ala?Asp?Asn?Ile?Arg?Pro?Thr

245 250 255

Thr?Val?Arg?Lys?His?Asn?Ala?Glu?Ser?Thr?Glu?Gln?Ala?Asp?Pro?Ile

260 265 270

Phe?Asn?Phe?Phe?Leu?Glu?Arg?Tyr?Asp?Ala?Ala?Tyr?Lys?Ala?Glu?Leu

275 280 285

Ala?Thr?Phe?Ala?Gln?Gly?Ile?Arg?Asp?Gly?Gln?Gly?Phe?Ser?Pro?Asn

290 295 300

Phe?Glu?Asp?Gly?Val?Ile?Ala?Leu?Glu?Leu?Ala?Asn?Ala?Cys?Leu?Glu

305 310 315 320

Ser?Ala?Gln?Thr?Gly?Arg?Thr?Val?Thr?Leu?Asn?Pro?Ala?Asn?Val

325 330 335

<210>301

<211>1206

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1183)

<223>RXA01633

<400>301

gcgaatgcat?gccttgaatc?agctcaaacc?ggccgcaccg?tcaccctcaa?ccctgccaac?60

gtttagtcaa?cgtctagtta?atgcctaagg?agaaaacctc?atg?aaa?aac?atc?acc 115

Met?Lys?Asn?Ile?Thr

1 5

atc?gga?atg?gtc?ggc?gtc?ggc?cgc?att?ggc?cgc?atg?cac?gtc?gcc?aac 163

Ile?Gly?Met?Val?Gly?Val?Gly?Arg?Ile?Gly?Arg?Met?His?Val?Ala?Asn

10 15 20

atg?ctt?gcc?gtt?gct?gaa?act?ttg?aag?gaa?cgc?gac?ctc?aac?att?gag 211

Met?Leu?Ala?Val?Ala?Glu?Thr?Leu?Lys?Glu?Arg?Asp?Leu?Asn?Ile?Glu

25 30 35

atc?gtg?ctc?gca?gac?gca?atg?ccc?ggt?ttt?gcg?gag?cag?gtg?ggc?gcg 259

Ile?Val?Leu?Ala?Asp?Ala?Met?Pro?Gly?Phe?Ala?Glu?Gln?Val?Gly?Ala

40 45 50

gac?atg?ggc?gtg?aag?gcg?gcg?gca?agc?gtc?gat?aag?ctt?att?gag?gac 307

Asp?Met?Gly?Val?Lys?Ala?Ala?Ala?Ser?Val?Asp?Lys?Leu?Ile?Glu?Asp

55 60 65

ggg?gtg?gat?gcc?ctt?ttc?att?gcc?acc?agc?acc?gct?ggc?cac?gtc?gat 355

Gly?Val?Asp?Ala?Leu?Phe?Ile?Ala?Thr?Ser?Thr?Ala?Gly?His?Val?Asp

70 75 80 85

gtt?ttg?cgc?aag?ggc?atc?gcg?gca?aag?ctg?ccg?atg?ttc?tgc?gag?aag 403

Val?Leu?Arg?Lys?Gly?Ile?Ala?Ala?Lys?Leu?Pro?Met?Phe?Cys?Glu?Lys

90 95 100

ccg?atc?gcg?tcg?gat?gtg?cct?gag?tcg?ctg?aac?atc?atc?cgc?gaa?att 451

Pro?Ile?Ala?Ser?Asp?Val?Pro?Glu?Ser?Leu?Asn?Ile?Ile?Arg?Glu?Ile

105 110 115

gat?gcg?gct?ggc?gcg?acg?gtt?cag?gtc?ggc?cac?cag?cgc?cgt?ttt?gac 499

Asp?Ala?Ala?Gly?Ala?Thr?Val?Gln?Val?Gly?His?Gln?Arg?Arg?Phe?Asp

120 125 130

ctc?ggt?tac?cag?gaa?gct?aaa?cga?cgc?cta?gat?gca?ggc?gac?ctc?ggc 547

Leu?Gly?Tyr?Gln?Glu?Ala?Lys?Arg?Arg?Leu?Asp?Ala?Gly?Asp?Leu?Gly

135 140 145

tgg?ctt?cat?tcg?ctc?aag?gcc?gta?tcg?agc?gat?gcg?ttt?ccg?cca?ccg 595

Trp?Leu?His?Ser?Leu?Lys?Ala?Val?Ser?Ser?Asp?Ala?Phe?Pro?Pro?Pro

150 155 160 165

gtg?tcc?tac?tgc?gct?acc?tct?ggt?gga?ctt?ttc?cgc?gat?gtg?tcg?ctg 643

Val?Ser?Tyr?Cys?Ala?Thr?Ser?Gly?Gly?Leu?Phe?Arg?Asp?Val?Ser?Leu

170 175 180

cac?gat?ttc?gac?atc?att?cgc?tgg?ctg?acc?ggc?cag?gat?att?gtc?gag 691

His?Asp?Phe?Asp?Ile?Ile?Arg?Trp?Leu?Thr?Gly?Gln?Asp?Ile?Val?Glu

185 190 195

gtg?tac?gcc?aag?ggc?agc?aac?aac?ggc?gac?cca?gaa?atc?ggc?gca?gtc 739

Val?Tyr?Ala?Lys?Gly?Ser?Asn?Asn?Gly?Asp?Pro?Glu?Ile?Gly?Ala?Val

200 205 210

ggt?gac?atc?gat?acc?gga?gcg?gcc?cta?ctc?acg?ctt?gcc?gac?ggc?acc 787

Gly?Asp?Ile?Asp?Thr?Gly?Ala?Ala?Leu?Leu?Thr?Leu?Ala?Asp?Gly?Thr

215 220 225

ctc?gcc?acc?gcc?atc?gcc?act?cgt?tac?aac?ggt?gca?ggc?cac?gac?gtt 835

Leu?Ala?Thr?Ala?Ile?Ala?Thr?Arg?Tyr?Asn?Gly?Ala?Gly?His?Asp?Val

230 235 240 245

cgc?ctc?gat?gtt?atg?ggc?tct?aaa?gat?tcc?acg?atc?gtt?ggc?ctg?gat 883

Arg?Leu?Asp?Val?Met?Gly?Ser?Lys?Asp?Ser?Thr?Ile?Val?Gly?Leu?Asp

250 255 260

gaa?aag?tct?gcg?ttc?gct?tct?gcg?gag?gag?ggc?atc?gat?ttc?cca?acc 931

Glu?Lys?Ser?Ala?Phe?Ala?Ser?Ala?Glu?Glu?Gly?Ile?Asp?Phe?Pro?Thr

265 270 275

ggc?gaa?tcg?cac?cca?acg?ttt?gcc?gag?cgc?ttc?gcc?gac?gca?tac?aag 979

Gly?Glu?Ser?His?Pro?Thr?Phe?Ala?Glu?Arg?Phe?Ala?Asp?Ala?Tyr?Lys

280 285 290

aat?gag?tgc?att?gcg?ttc?gtg?gag?ttg?atc?ctg?gga?gag?cgg?gaa?aac 1027

Asn?Glu?Cys?Ile?Ala?Phe?Val?Glu?Leu?Ile?Leu?Gly?Glu?Arg?Glu?Asn

295 300 305

cct?tgt?acc?cct?gca?gac?gct?gtg?gct?gcg?gcg?att?gtt?gcc?gat?gca 1075

Pro?Cys?Thr?Pro?Ala?Asp?Ala?Val?Ala?Ala?Ala?Ile?Val?Ala?Asp?Ala

310 315 320 325

gct?cag?ctg?tcg?ctg?gtc?act?ggc?gag?cca?gtg?aag?att?cct?act?gta 1123

Ala?Gln?Leu?Ser?Leu?Val?Thr?Gly?Glu?Pro?Val?Lys?Ile?Pro?Thr?Val

330 335 340

cgg?gaa?att?ctt?gaa?ggt?tct?gcg?cag?cca?gtt?gag?gtg?cgt?gcg?ctg 1171

Arg?Glu?Ile?Leu?Glu?Gly?Ser?Ala?Gln?Pro?Val?Glu?Val?Arg?Ala?Leu

345 350 355

gtt?cca?tct?gct?taaaacctta?ctgcttatct?aaa 1206

Val?Pro?Ser?Ala

360

<210>302

<211>361

<212>PRT

＜213〉Corynebacterium glutamicum

<400>302

Met?Lys?Asn?Ile?Thr?Ile?Gly?Met?Val?Gly?Val?Gly?Arg?Ile?Gly?Arg

1 5 10 15

Met?His?Val?Ala?Asn?Met?Leu?Ala?Val?Ala?Glu?Thr?Leu?Lys?Glu?Arg

20 25 30

Asp?Leu?Asn?Ile?Glu?Ile?Val?Leu?Ala?Asp?Ala?Met?Pro?Gly?Phe?Ala

35 40 45

Glu?Gln?Val?Gly?Ala?Asp?Met?Gly?Val?Lys?Ala?Ala?Ala?Ser?Val?Asp

50 55 60

Lys?Leu?Ile?Glu?Asp?Gly?Val?Asp?Ala?Leu?Phe?Ile?Ala?Thr?Ser?Thr

65 70 75 80

Ala?Gly?His?Val?Asp?Val?Leu?Arg?Lys?Gly?Ile?Ala?Ala?Lys?Leu?Pro

85 90 95

Met?Phe?Cys?Glu?Lys?Pro?Ile?Ala?Ser?Asp?Val?Pro?Glu?Ser?Leu?Asn

100 105 110

Ile?Ile?Arg?Glu?Ile?Asp?Ala?Ala?Gly?Ala?Thr?Val?Gln?Val?Gly?His

115 120 125

Gln?Arg?Arg?Phe?Asp?Leu?Gly?Tyr?Gln?Glu?Ala?Lys?Arg?Arg?Leu?Asp

130 135 140

Ala?Gly?Asp?Leu?Gly?Trp?Leu?His?Ser?Leu?Lys?Ala?Val?Ser?Ser?Asp

145 150 155 160

Ala?Phe?Pro?Pro?Pro?Val?Ser?Tyr?Cys?Ala?Thr?Ser?Gly?Gly?Leu?Phe

165 170 175

Arg?Asp?Val?Ser?Leu?His?Asp?Phe?Asp?Ile?Ile?Arg?Trp?Leu?Thr?Gly

180 185 190

Gln?Asp?Ile?Val?Glu?Val?Tyr?Ala?Lys?Gly?Ser?Asn?Asn?Gly?Asp?Pro

195 200 205

Glu?Ile?Gly?Ala?Val?Gly?Asp?Ile?Asp?Thr?Gly?Ala?Ala?Leu?Leu?Thr

210 215 220

Leu?Ala?Asp?Gly?Thr?Leu?Ala?Thr?Ala?Ile?Ala?Thr?Arg?Tyr?Asn?Gly

225 230 235 240

Ala?Gly?His?Asp?Val?Arg?Leu?Asp?Val?Met?Gly?Ser?Lys?Asp?Ser?Thr

245 250 255

Ile?Val?Gly?Leu?Asp?Glu?Lys?Ser?Ala?Phe?Ala?Ser?Ala?Glu?Glu?Gly

260 265 270

Ile?Asp?Phe?Pro?Thr?Gly?Glu?Ser?His?Pro?Thr?Phe?Ala?Glu?Arg?Phe

275 280 285

Ala?Asp?Ala?Tyr?Lys?Asn?Glu?Cys?Ile?Ala?Phe?Val?Glu?Leu?Ile?Leu

290 295 300

Gly?Glu?Arg?Glu?Asn?Pro?Cys?Thr?Pro?Ala?Asp?Ala?Val?Ala?Ala?Ala

305 310 315 320

Ile?Val?Ala?Asp?Ala?Ala?Gln?Leu?Ser?Leu?Val?Thr?Gly?Glu?Pro?Val

325 330 335

Lys?Ile?Pro?Thr?Val?Arg?Glu?Ile?Leu?Glu?Gly?Ser?Ala?Gln?Pro?Val

340 345 350

Glu?Val?Arg?Ala?Leu?Val?Pro?Ser?Ala

355 360

<210>303

<211>1146

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1123)

<223>RXN01406

<400>303

gttcctcatt?cctctaatcg?gcgcactatc?tttgcctcgc?gacggcggtg?cccgagcctt?60

ttcctcctct?tagaaaccca?cttctgaaag?gtataaaaac?atg?act?att?cga?atc 115

Met?Thr?Ile?Arg?Ile

1 5

gga?ctc?gtt?ggc?tac?ggt?gtc?ggc?ggc?agg?ctc?ttt?cac?acc?cct?tac 163

Gly?Leu?Val?Gly?Tyr?Gly?Val?Gly?Gly?Arg?Leu?Phe?His?Thr?Pro?Tyr

10 15 20

atc?caa?gct?tct?acg?cac?tgc?gaa?tta?gta?ggc?gta?gtt?gct?cgt?tcc 211

Ile?Gln?Ala?Ser?Thr?His?Cys?Glu?Leu?Val?Gly?Val?Val?Ala?Arg?Ser

25 30 35

gaa?ggc?acc?aaa?gca?gcc?gtt?gca?gaa?gat?ctt?cca?gat?gtt?gcc?atc 259

Glu?Gly?Thr?Lys?Ala?Ala?Val?Ala?Glu?Asp?Leu?Pro?Asp?Val?Ala?Ile

40 45 50

gtg?gga?tcg?ctg?aca?gaa?ctc?ctc?gaa?ctg?ggc?gtc?gat?gca?gtg?gtg 307

Val?Gly?Ser?Leu?Thr?Glu?Leu?Leu?Glu?Leu?Gly?Val?Asp?Ala?Val?Val

55 60 65

atc?tcc?acc?cct?cca?gcc?acg?cgc?cgg?gaa?ctg?gcc?ttg?gaa?gca?atc 355

Ile?Ser?Thr?Pro?Pro?Ala?Thr?Arg?Arg?Glu?Leu?Ala?Leu?Glu?Ala?Ile

70 75 80 85

aac?gca?ggt?gtc?gca?gtg?gtt?gcc?gat?aaa?ccg?ttt?gca?cca?tca?gcc 403

Asn?Ala?Gly?Val?Ala?Val?Val?Ala?Asp?Lys?Pro?Phe?Ala?Pro?Ser?Ala

90 95 100

gca?gat?gcc?atg?gaa?ctt?gtc?gaa?gcc?gcc?gaa?aag?gct?gga?gtg?ctg 451

Ala?Asp?Ala?Met?Glu?Leu?Val?Glu?Ala?Ala?Glu?Lys?Ala?Gly?Val?Leu

105 110 115

ctc?aac?gtc?ttc?cac?aac?agg?cgc?aac?gac?acc?cac?att?gtc?acg?gca 499

Leu?Asn?Val?Phe?His?Asn?Arg?Arg?Asn?Asp?Thr?His?Ile?Val?Thr?Ala

120 125 130

ctg?gga?atc?caa?gaa?gaa?ctt?ggt?gcg?atg?cgt?gga?ctg?gac?ctg?cga 547

Leu?Gly?Ile?Gln?Glu?Glu?Leu?Gly?Ala?Met?Arg?Gly?Leu?Asp?Leu?Arg

135 140 145

cta?gac?ctg?atc?gaa?cct?gat?tcc?ttg?gag?gca?ggt?cct?gaa?ggt?ggt 595

Leu?Asp?Leu?Ile?Glu?Pro?Asp?Ser?Leu?Glu?Ala?Gly?Pro?Glu?Gly?Gly

150 155 160 165

ttg?ctg?cgc?gat?ctg?ggc?tca?cac?gta?gtc?gat?cag?acc?ctg?gtt?ctc 643

Leu?Leu?Arg?Asp?Leu?Gly?Ser?His?Val?Val?Asp?Gln?Thr?Leu?Val?Leu

170 175 180

atg?ggg?ccg?gct?acc?tct?gtc?acc?gcc?caa?ctt?gga?tcc?atc?gac?ctt 691

Met?Gly?Pro?Ala?Thr?Ser?Val?Thr?Ala?Gln?Leu?Gly?Ser?Ile?Asp?Leu

185 190 195

cca?gaa?ggc?cca?acc?aac?gca?agg?ttc?cgc?atc?gtg?ttg?gaa?cat?gaa 739

Pro?Glu?Gly?Pro?Thr?Asn?Ala?Arg?Phe?Arg?Ile?Val?Leu?Glu?His?Glu

200 205 210

tcg?ggc?gcc?gta?tcg?cac?att?tct?gcc?agc?aag?att?gac?cgc?ttg?gag 787

Ser?Gly?Ala?Val?Ser?His?Ile?Ser?Ala?Ser?Lys?Ile?Asp?Arg?Leu?Glu

215 220 225

tcc?tgg?gaa?atc?cgc?ttg?gtg?ggc?gag?cgc?ggc?tcc?tac?gta?tcc?aac 835

Ser?Trp?Glu?Ile?Arg?Leu?Val?Gly?Glu?Arg?Gly?Ser?Tyr?Val?Ser?Asn

230 235 240 245

tac?acc?gac?gtg?cag?acc?gtg?gcg?atc?aaa?cag?gga?ctt?cga?cca?acc 883

Tyr?Thr?Asp?Val?Gln?Thr?Val?Ala?Ile?Lys?Gln?Gly?Leu?Arg?Pro?Thr

250 255 260

aat?gac?cgc?gaa?cac?tgg?ggc?tac?gaa?tcg?gag?gag?cgg?tgg?ggc?acc 931

Asn?Asp?Arg?Glu?His?Trp?Gly?Tyr?Glu?Ser?Glu?Glu?Arg?Trp?Gly?Thr

265 270 275

ttg?gtt?acc?gat?gaa?ggc?tca?aag?gtg?att?cct?tca?gca?caa?ggc?gat 979

Leu?Val?Thr?Asp?Glu?Gly?Ser?Lys?Val?Ile?Pro?Ser?Ala?Gln?Gly?Asp

280 285 290

tac?acc?cgc?ttc?tac?gat?gcc?ttt?gcc?ttg?gct?gtg?gaa?aac?ggt?ggc 1027

Tyr?Thr?Arg?Phe?Tyr?Asp?Ala?Phe?Ala?Leu?Ala?Val?Glu?Asn?Gly?Gly

295 300 305

gca?ggg?ccg?gtg?cct?gca?cgt?gaa?ggt?gtt?gca?gtg?ctc?aag?gtg?ttg 1075

Ala?Gly?Pro?Val?Pro?Ala?Arg?Glu?Gly?Val?Ala?Val?Leu?Lys?Val?Leu

310 315 320 325

gat?gct?gta?gcc?cag?agc?gct?gcg?gaa?aaa?cgc?acc?att?gag?ttg?agc 1123

Asp?Ala?Val?Ala?Gln?Ser?Ala?Ala?Glu?Lys?Arg?Thr?Ile?Glu?Leu?Ser

330 335 340

taaggagaag?tgctgctggc?tgc 1146

<210>304

<211>341

<212>PRT

＜213〉Corynebacterium glutamicum

<400>304

Met?Thr?Ile?Arg?Ile?Gly?Leu?Val?Gly?Tyr?Gly?Val?Gly?Gly?Arg?Leu

1 5 10 15

Phe?His?Thr?Pro?Tyr?Ile?Gln?Ala?Ser?Thr?His?Cys?Glu?Leu?Val?Gly

20 25 30

Val?Val?Ala?Arg?Ser?Glu?Gly?Thr?Lys?Ala?Ala?Val?Ala?Glu?Asp?Leu

35 40 45

Pro?Asp?Val?Ala?Ile?Val?Gly?Ser?Leu?Thr?Glu?Leu?Leu?Glu?Leu?Gly

50 55 60

Val?Asp?Ala?Val?Val?Ile?Ser?Thr?Pro?Pro?Ala?Thr?Arg?Arg?Glu?Leu

65 70 75 80

Ala?Leu?Glu?Ala?Ile?Asn?Ala?Gly?Val?Ala?Val?Val?Ala?Asp?Lys?Pro

85 90 95

Phe?Ala?Pro?Ser?Ala?Ala?Asp?Ala?Met?Glu?Leu?Val?Glu?Ala?Ala?Glu

100 105 110

Lys?Ala?Gly?Val?Leu?Leu?Asn?Val?Phe?His?Asn?Arg?Arg?Asn?Asp?Thr

115 120 125

His?Ile?Val?Thr?Ala?Leu?Gly?Ile?Gln?Glu?Glu?Leu?Gly?Ala?Met?Arg

130 135 140

Gly?Leu?Asp?Leu?Arg?Leu?Asp?Leu?Ile?Glu?Pro?Asp?Ser?Leu?Glu?Ala

145 150 155 160

Gly?Pro?Glu?Gly?Gly?Leu?Leu?Arg?Asp?Leu?Gly?Ser?His?Val?Val?Asp

165 170 175

Gln?Thr?Leu?Val?Leu?Met?Gly?Pro?Ala?Thr?Ser?Val?Thr?Ala?Gln?Leu

180 185 190

Gly?Ser?Ile?Asp?Leu?Pro?Glu?Gly?Pro?Thr?Asn?Ala?Arg?Phe?Arg?Ile

195 200 205

Val?Leu?Glu?His?Glu?Ser?Gly?Ala?Val?Ser?His?Ile?Ser?Ala?Ser?Lys

210 215 220

Ile?Asp?Arg?Leu?Glu?Ser?Trp?Glu?Ile?Arg?Leu?Val?Gly?Glu?Arg?Gly

225 230 235 240

Ser?Tyr?Val?Ser?Asn?Tyr?Thr?Asp?Val?Gln?Thr?Val?Ala?Ile?Lys?Gln

245 250 255

Gly?Leu?Arg?Pro?Thr?Asn?Asp?Arg?Glu?His?Trp?Gly?Tyr?Glu?Ser?Glu

260 265 270

Glu?Arg?Trp?Gly?Thr?Leu?Val?Thr?Asp?Glu?Gly?Ser?Lys?Val?Ile?Pro

275 280 285

Ser?Ala?Gln?Gly?Asp?Tyr?Thr?Arg?Phe?Tyr?Asp?Ala?Phe?Ala?Leu?Ala

290 295 300

Val?Glu?Asn?Gly?Gly?Ala?Gly?Pro?Val?Pro?Ala?Arg?Glu?Gly?Val?Ala

305 310 315 320

Val?Leu?Lys?Val?Leu?Asp?Ala?Val?Ala?Gln?Ser?Ala?Ala?Glu?Lys?Arg

325 330 335

Thr?Ile?Glu?Leu?Ser

340

<210>305

<21l>1200

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1177)

<223>RXN01630

<400>305

gtaggtgagt?cttcgtgaga?tacccccggc?cagtcataca?gttcaaccaa?gctccaccac?60

ccagataaaa?acctgcgggt?tgcgttttag?gagaattccc?atg?agt?gat?caa?aaa 115

Met?Ser?Asp?Gln?Lys

1 5

att?gtt?gtt?ggc?ctg?cta?ggc?atc?acc?cac?ccg?cat?gcg?tcg?gcg?cgg 163

Ile?Val?Val?Gly?Leu?Leu?Gly?Ile?Thr?His?Pro?His?Ala?Ser?Ala?Arg

10 15 20

gtg?cgt?gcc?ctc?cgt?gaa?att?gat?ggg?gta?gag?gtc?gtc?gcc?gcc?gcg 211

Val?Arg?Ala?Leu?Arg?Glu?Ile?Asp?Gly?Val?Glu?Val?Val?Ala?Ala?Ala

25 30 35

gat?act?gat?tcc?cgc?ctc?cag?tac?ttc?acc?gac?aaa?tat?gat?gtt?gaa 259

Asp?Thr?Asp?Ser?Arg?Leu?Gln?Tyr?Phe?Thr?Asp?Lys?Tyr?Asp?Val?Glu

40 45 50

ccc?cgc?gag?atc?gat?gac?gtc?ttg?aac?gac?gat?cgc?atc?aac?gcc?atc 307

Pro?Arg?Glu?Ile?Asp?Asp?Val?Leu?Asn?Asp?Asp?Arg?Ile?Asn?Ala?Ile

55 60 65

atg?gtt?cac?tcc?aag?agc?aag?gac?atg?gtc?cct?cac?gcc?aag?cgc?gcg 355

Met?Val?His?Ser?Lys?Ser?Lys?Asp?Met?Val?Pro?His?Ala?Lys?Arg?Ala

70 75 80 85

ctc?gcg?gcc?gga?aaa?tcc?gtc?gtc?gtg?gag?aag?ccc?ggc?ggg?gga?aca 403

Leu?Ala?Ala?Gly?Lys?Ser?Val?Val?Val?Glu?Lys?Pro?Gly?Gly?Gly?Thr

90 95 100

gtg?gcg?gat?ctt?gag?gag?ctc?ctg?gcc?ctc?aaa?gaa?gct?gcc?gat?cct 451

Val?Ala?Asp?Leu?Glu?Glu?Leu?Leu?Ala?Leu?Lys?Glu?Ala?Ala?Asp?Pro

105 110 115

cag?cga?atc?gtg?cag?gtc?ggg?tac?aac?gtc?cgc?ctg?tct?gaa?tcg?gtt 499

Gln?Arg?Ile?Val?Gln?Val?Gly?Tyr?Asn?Val?Arg?Leu?Ser?Glu?Ser?Val

120 125 130

cag?aga?tta?aaa?gag?ctt?ctc?gac?gcc?ggc?ctc?atc?ggc?gaa?gtc?gtc 547

Gln?Arg?Leu?Lys?Glu?Leu?Leu?Asp?Ala?Gly?Leu?Ile?Gly?Glu?Val?Val

135 140 145

agc?gtg?caa?gca?cgc?ggc?gcc?gca?aaa?gta?ggt?gag?cat?atc?acc?gag 595

Ser?Val?Gln?Ala?Arg?Gly?Ala?Ala?Lys?Val?Gly?Glu?His?Ile?Thr?Glu

150 155 160 165

cac?ctc?aac?caa?ccc?gca?gac?atg?ggc?ggt?gtg?ttg?tgg?att?ctt?ggc 643

His?Leu?Asn?Gln?Pro?Ala?Asp?Met?Gly?Gly?Val?Leu?Trp?Ile?Leu?Gly

170 175 180

tgc?cac?atg?ctc?gat?gca?ttg?gtg?gaa?gtc?ttc?gga?gct?cca?gaa?tcc 691

Cys?His?Met?Leu?Asp?Ala?Leu?Val?Glu?Val?Phe?Gly?Ala?Pro?Glu?Ser

185 190 195

gtg?aac?gcc?cga?gtg?cat?aag?acc?gca?aaa?ctc?tct?gac?gac?acc?agc 739

Val?Asn?Ala?Arg?Val?His?Lys?Thr?Ala?Lys?Leu?Ser?Asp?Asp?Thr?Ser

200 205 210

cgc?gaa?gac?tca?gcc?tcc?gca?ctg?ctg?tac?tac?cca?gat?ttc?tcc?gtc 787

Arg?Glu?Asp?Ser?Ala?Ser?Ala?Leu?Leu?Tyr?Tyr?Pro?Asp?Phe?Ser?Val

215 220 225

agc?ttc?agc?ttc?gac?ggc?cac?gat?gat?ctg?gaa?tgg?ttc?gaa?agc?tcc 835

Ser?Phe?Ser?Phe?Asp?Gly?His?Asp?Asp?Leu?Glu?Trp?Phe?Glu?Ser?Ser

230 235 240 245

cga?ctc?acg?gtc?tat?gga?acc?aag?ggc?atg?atc?gaa?gcc?gga?atc?ctc 883

Arg?Leu?Thr?Val?Tyr?Gly?Thr?Lys?Gly?Met?Ile?Glu?Ala?Gly?Ile?Leu

250 255 260

cct?cag?aca?ctg?cgc?gta?tac?ctc?aat?gag?tca?cgc?cag?ggc?tgg?cca 931

Pro?Gln?Thr?Leu?Arg?Val?Tyr?Leu?Asn?Glu?Ser?Arg?Gln?Gly?Trp?Pro

265 270 275

cag?ggt?tgg?acc?gag?tgg?acc?cag?agc?tac?ttc?acc?cca?ccg?ttt?gct 979

Gln?Gly?Trp?Thr?Glu?Trp?Thr?Gln?Ser?Tyr?Phe?Thr?Pro?Pro?Phe?Ala

280 285 290

cgc?aca?gaa?tcc?aac?aaa?ttc?tca?gag?ctt?cca?gag?cta?gaa?aac?atc 1027

Arg?Thr?Glu?Ser?Asn?Lys?Phe?Ser?Glu?Leu?Pro?Glu?Leu?Glu?Asn?Ile

295 300 305

agc?aac?ttc?cgc?aca?gaa?atg?cag?ggg?tgg?gtg?aat?tcc?att?cgc?act 1075

Ser?Asn?Phe?Arg?Thr?Glu?Met?Gln?Gly?Trp?Val?Asn?Ser?Ile?Arg?Thr

310 315 320 325

gga?tcc?cgc?aat?gtg?gcg?cca?gtt?gag?gat?gct?ctc?aca?gtc?gct?cgc 1123

Gly?Ser?Arg?Asn?Val?Ala?Pro?Val?Glu?Asp?Ala?Leu?Thr?Val?Ala?Arg

330 335 340

att?gtc?agt?gca?tgc?tac?gaa?tcc?gac?aac?aac?cag?ggc?att?tcc?gta 1171

Ile?Val?Ser?Ala?Cys?Tyr?Glu?Ser?Asp?Asn?Asn?Gln?Gly?Ile?Ser?Val

345 350 355

aac?atc?taagaggagc?actccatgaa?acc 1200

Asn?Ile

<210>306

<211>359

<212>PRT

＜213〉Corynebacterium glutamicum

<400>306

Met?Ser?Asp?Gln?Lys?Ile?Val?Val?Gly?Leu?Leu?Gly?Ile?Thr?His?Pro

1 5 10 15

His?Ala?Ser?Ala?Arg?Val?Arg?Ala?Leu?Arg?Glu?Ile?Asp?Gly?Val?Glu

20 25 30

Val?Val?Ala?Ala?Ala?Asp?Thr?Asp?Ser?Arg?Leu?Gln?Tyr?Phe?Thr?Asp

35 40 45

Lys?Tyr?Asp?Val?Glu?Pro?Arg?Glu?Ile?Asp?Asp?Val?Leu?Asn?Asp?Asp

50 55 60

Arg?Ile?Asn?Ala?Ile?Met?Val?His?Ser?Lys?Ser?Lys?Asp?Met?Val?Pro

65 70 75 80

His?Ala?Lys?Arg?Ala?Leu?Ala?Ala?Gly?Lys?Ser?Val?Val?Val?Glu?Lys

85 90 95

Pro?Gly?Gly?Gly?Thr?Val?Ala?Asp?Leu?Glu?Glu?Leu?Leu?Ala?Leu?Lys

100 105 110

Glu?Ala?Ala?Asp?Pro?Gln?Arg?Ile?Val?Gln?Val?Gly?Tyr?Asn?Val?Arg

115 120 125

Leu?Ser?Glu?Ser?Val?Gln?Arg?Leu?Lys?Glu?Leu?Leu?Asp?Ala?Gly?Leu

130 135 140

Ile?Gly?Glu?Val?Val?Ser?Val?Gln?Ala?Arg?Gly?Ala?Ala?Lys?Val?Gly

145 150 155 160

Glu?His?Ile?Thr?Glu?His?Leu?Asn?Gln?Pro?Ala?Asp?Met?Gly?Gly?Val

165 170 175

Leu?Trp?Ile?Leu?Gly?Cys?His?Met?Leu?Asp?Ala?Leu?Val?Glu?Val?Phe

180 185 190

Gly?Ala?Pro?Glu?Ser?Val?Asn?Ala?Arg?Val?His?Lys?Thr?Ala?Lys?Leu

195 200 205

Ser?Asp?Asp?Thr?Ser?Arg?Glu?Asp?Ser?Ala?Ser?Ala?Leu?Leu?Tyr?Tyr

210 215 220

Pro?Asp?Phe?Ser?Val?Ser?Phe?Ser?Phe?Asp?Gly?His?Asp?Asp?Leu?Glu

225 230 235 240

Trp?Phe?Glu?Ser?Ser?Arg?Leu?Thr?Val?Tyr?Gly?Thr?Lys?Gly?Met?Ile

245 250 255

Glu?Ala?Gly?Ile?Leu?Pro?Gln?Thr?Leu?Arg?Val?Tyr?Leu?Asn?Glu?Ser

260 265 270

Arg?Gln?Gly?Trp?Pro?Gln?Gly?Trp?Thr?Glu?Trp?Thr?Gln?Ser?Tyr?Phe

275 280 285

Thr?Pro?Pro?Phe?Ala?Arg?Thr?Glu?Ser?Asn?Lys?Phe?Ser?Glu?Leu?Pro

290 295 300

Glu?Leu?Glu?Asn?Ile?Ser?Asn?Phe?Arg?Thr?Glu?Met?Gln?Gly?Trp?Val

305 310 315 320

Asn?Ser?Ile?Arg?Thr?Gly?Ser?Arg?Asn?Val?Ala?Pro?Val?Glu?Asp?Ala

325 330 335

Leu?Thr?Val?Ala?Arg?Ile?Val?Ser?Ala?Cys?Tyr?Glu?Ser?Asp?Asn?Asn

340 345 350

Gln?Gly?Ile?Ser?Val?Asn?Ile

355

<210>307

<211>1212

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1189)

<223>RXN00528

<400>307

ttctgctggg?aatccccaca?ttttggaacg?tagcgtcgat?aagcgtgcgg?cgaagctttt?60

tcggtcgcgg?ccgttatctt?tttaagagga?gaaattttag?atg?agc?acg?tcc?acc 115

Met?Ser?Thr?Ser?Thr

1 5

atc?agg?gtt?gcc?att?gcc?gga?gtc?gga?aac?tgc?gcg?acc?tcc?ctc?att 163

Ile?Arg?Val?Ala?Ile?Ala?Gly?Val?Gly?Asn?Cys?Ala?Thr?Ser?Leu?Ile

10 15 20

cag?ggt?gtg?gaa?tat?tac?cga?aat?gcg?gat?cct?tcc?gaa?act?gtc?ccg 211

Gln?Gly?Val?Glu?Tyr?Tyr?Arg?Asn?Ala?Asp?Pro?Ser?Glu?Thr?Val?Pro

25 30 35

ggt?ttg?atg?cac?gtc?aaa?ttc?ggt?gat?tac?cac?gtt?ggc?gac?att?gaa 259

Gly?Leu?Met?His?Val?Lys?Phe?Gly?Asp?Tyr?His?Val?Gly?Asp?Ile?Glu

40 45 50

ttc?gtg?gcc?gcg?ttc?gac?gtc?gac?gcc?gaa?aaa?gta?ggc?atc?gat?ctt 307

Phe?Val?Ala?Ala?Phe?Asp?Val?Asp?Ala?Glu?Lys?Val?Gly?Ile?Asp?Leu

55 60 65

gcc?gac?gcc?acc?gag?gct?tca?caa?aac?tgc?act?atc?aaa?atc?gcc?gat 355

Ala?Asp?Ala?Thr?Glu?Ala?Ser?Gln?Asn?Cys?Thr?Ile?Lys?Ile?Ala?Asp

70 75 80 85

gtc?cca?cag?acc?ggc?atc?aac?gtg?ctg?cgt?ggc?ccg?act?ctc?gac?ggc 403

Val?Pro?Gln?Thr?Gly?Ile?Asn?Val?Leu?Arg?Gly?Pro?Thr?Leu?Asp?Gly

90 95 100

ctg?ggc?gat?cat?tac?cgc?gcg?acc?atc?gac?gag?tcc?acc?gcc?gag?cca 451

Leu?Gly?Asp?His?Tyr?Arg?Ala?Thr?Ile?Asp?Glu?Ser?Thr?Ala?Glu?Pro

105 110 115

gtc?gac?gtt?gtc?cag?gcg?ctt?atc?gac?gca?aaa?gcc?gat?gtt?ttg?gtg 499

Val?Asp?Val?Val?Gln?Ala?Leu?Ile?Asp?Ala?Lys?Ala?Asp?Val?Leu?Val

120 125 130

tcc?tac?ctc?cca?gtg?ggc?tcc?gaa?gaa?gcc?gac?aaa?ttc?tac?gca?caa 547

Ser?Tyr?Leu?Pro?Val?Gly?Ser?Glu?Glu?Ala?Asp?Lys?Phe?Tyr?Ala?Gln

135 140 145

gcc?gcc?atc?gat?gca?ggc?tgc?gcc?ttt?gtc?aac?gct?ctc?cca?gta?ttc 595

Ala?Ala?Ile?Asp?Ala?Gly?Cys?Ala?Phe?Val?Asn?Ala?Leu?Pro?Val?Phe

150 155 160 165

atc?gcc?tcc?gac?cct?gag?tgg?gct?aag?aag?ttc?act?gac?gct?ggc?atc 643

Ile?Ala?Ser?Asp?Pro?Glu?Trp?Ala?Lys?Lys?Phe?Thr?Asp?Ala?Gly?Ile

170 175 180

cca?att?gtt?ggc?gat?gac?atc?aaa?tcc?cag?atc?ggt?gca?acc?atc?acc 691

Pro?Ile?Val?Gly?Asp?Asp?Ile?Lys?Ser?Gln?Ile?Gly?Ala?Thr?Ile?Thr

185 190 195

cac?cgt?gtc?ctc?gca?cgc?ctt?ttt?gaa?gaa?cgt?ggc?gtt?cgc?gta?gat 739

His?Arg?Val?Leu?Ala?Arg?Leu?Phe?Glu?Glu?Arg?Gly?Val?Arg?Val?Asp

200 205 210

cgc?acc?atg?cag?ctc?aac?gtc?ggc?ggc?aac?atg?gac?ttc?aaa?aac?atg 787

Arg?Thr?Met?Gln?Leu?Asn?Val?Gly?Gly?Asn?Met?Asp?Phe?Lys?Asn?Met

215 220 225

ctt?gac?cgc?aat?cgc?ttg?gaa?tcc?aag?aag?gtc?tcc?aaa?acc?caa?gca 835

Leu?Asp?Arg?Asn?Arg?Leu?Glu?Ser?Lys?Lys?Val?Ser?Lys?Thr?Gln?Ala

230 235 240 245

gtg?acc?tcc?aac?att?cca?gat?ggt?cca?ctg?tct?gga?aag?gtg?gaa?gac 883

Val?Thr?Ser?Asn?Ile?Pro?Asp?Gly?Pro?Leu?Ser?Gly?Lys?Val?Glu?Asp

250 255 260

cgc?aac?gtc?cac?atc?gga?cca?tcc?gac?cac?gtc?caa?tgg?ctc?gat?gac 931

Arg?Asn?Val?His?Ile?Gly?Pro?Ser?Asp?His?Val?Gln?Trp?Leu?Asp?Asp

265 270 275

cgc?aag?tgg?gct?tat?gtc?cgc?ctc?gaa?ggc?acc?gca?ttc?ggt?gga?gtt 979

Arg?Lys?Trp?Ala?Tyr?Val?Arg?Leu?Glu?Gly?Thr?Ala?Phe?Gly?Gly?Val

280 285 290

ccc?ctc?aac?ctt?gag?tac?aaa?ctc?gag?gtg?tgg?gat?tca?ccc?aac?tct 1027

Pro?Leu?Asn?Leu?Glu?Tyr?Lys?Leu?Glu?Val?Trp?Asp?Ser?Pro?Asn?Ser

295 300 305

gcc?ggc?atc?atc?atc?gac?gct?gtt?cgc?gcc?gcc?aag?atc?gcc?ctc?gat 1075

Ala?Gly?Ile?Ile?Ile?Asp?Ala?Val?Arg?Ala?Ala?Lys?Ile?Ala?Leu?Asp

310 315 320 325

cgc?ggt?atc?ggc?gga?ccg?atc?atg?cca?gca?agc?tcc?tac?ctg?atg?aag 1123

Arg?Gly?Ile?Gly?Gly?Pro?Ile?Met?Pro?Ala?Ser?Ser?Tyr?Leu?Met?Lys

330 335 340

tcc?cca?cct?gag?cag?ctt?cca?gac?gat?gtt?gct?tgt?gaa?cgc?cta?gag 1171

Ser?Pro?Pro?Glu?Gln?Leu?Pro?Asp?Asp?Val?Ala?Cys?Glu?Arg?Leu?Glu

345 350 355

gca?ttc?atc?atc?gag?gcg?taaaattagg?ctaaaaattt?ggg 1212

Ala?Phe?Ile?Ile?Glu?Ala

360

<210>308

<211>363

<212>PRT

＜213〉Corynebacterium glutamicum

<400>308

Met?Ser?Thr?Ser?Thr?Ile?Arg?Val?Ala?Ile?Ala?Gly?Val?Gly?Asn?Cys

1 5 10 15

Ala?Thr?Ser?Leu?Ile?Gln?Gly?Val?Glu?Tyr?Tyr?Arg?Asn?Ala?Asp?Pro

20 25 30

Ser?Glu?Thr?Val?Pro?Gly?Leu?Met?His?Val?Lys?Phe?Gly?Asp?Tyr?His

35 40 45

Val?Gly?Asp?Ile?Glu?Phe?Val?Ala?Ala?Phe?Asp?Val?Asp?Ala?Glu?Lys

50 55 60

Val?Gly?Ile?Asp?Leu?Ala?Asp?Ala?Thr?Glu?Ala?Ser?Gln?Asn?Cys?Thr

65 70 75 80

Ile?Lys?Ile?Ala?Asp?Val?Pro?Gln?Thr?Gly?Ile?Asn?Val?Leu?Arg?Gly

85 90 95

Pro?Thr?Leu?Asp?Gly?Leu?Gly?Asp?His?Tyr?Arg?Ala?Thr?Ile?Asp?Glu

100 105 110

Ser?Thr?Ala?Glu?Pro?Val?Asp?Val?Val?Gln?Ala?Leu?Ile?Asp?Ala?Lys

115 120 125

Ala?Asp?Val?Leu?Val?Ser?Tyr?Leu?Pro?Val?Gly?Ser?Glu?Glu?Ala?Asp

130 135 140

Lys?Phe?Tyr?Ala?Gln?Ala?Ala?Ile?Asp?Ala?Gly?Cys?Ala?Phe?Val?Asn

145 150 155 160

Ala?Leu?Pro?Val?Phe?Ile?Ala?Ser?Asp?Pro?Glu?Trp?Ala?Lys?Lys?Phe

165 170 175

Thr?Asp?Ala?Gly?Ile?Pro?Ile?Val?Gly?Asp?Asp?Ile?Lys?Ser?Gln?Ile

180 185 190

Gly?Ala?Thr?Ile?Thr?His?Arg?Val?Leu?Ala?Arg?Leu?Phe?Glu?Glu?Arg

195 200 205

Gly?Val?Arg?Val?Asp?Arg?Thr?Met?Gln?Leu?Asn?Val?Gly?Gly?Asn?Met

210 215 220

Asp?Phe?Lys?Asn?Met?Leu?Asp?Arg?Asn?Arg?Leu?Glu?Ser?Lys?Lys?Val

225 230 235 240

Ser?Lys?Thr?Gln?Ala?Val?Thr?Ser?Asn?Ile?Pro?Asp?Gly?Pro?Leu?Ser

245 250 255

Gly?Lys?Val?Glu?Asp?Arg?Asn?Val?His?Ile?Gly?Pro?Ser?Asp?His?Val

260 265 270

Gln?Trp?Leu?Asp?Asp?Arg?Lys?Trp?Ala?Tyr?Val?Arg?Leu?Glu?Gly?Thr

275 280 285

Ala?Phe?Gly?Gly?Val?Pro?Leu?Asn?Leu?Glu?Tyr?Lys?Leu?Glu?Val?Trp

290 295 300

Asp?Ser?Pro?Asn?Ser?Ala?Gly?Ile?Ile?Ile?Asp?Ala?Val?Arg?Ala?Ala

305 310 315 320

Lys?Ile?Ala?Leu?Asp?Arg?Gly?Ile?Gly?Gly?Pro?Ile?Met?Pro?Ala?Ser

325 330 335

Ser?Tyr?Leu?Met?Lys?Ser?Pro?Pro?Glu?Gln?Leu?Pro?Asp?Asp?Val?Ala

340 345 350

Cys?Glu?Arg?Leu?Glu?Ala?Phe?Ile?Ile?Glu?Ala

355 360

<210>309

<211>795

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(772)

<223>RXN03057

<400>309

catcaacgcc?gagtacaact?aaggacaact?gataatgaca?aatgctgcaa?ttgtcggatg?60

aggagacgtc?gcaaccgttc?atacagaagc?gctggaagct?ttg?gct?tcc?gat?ctt 115

Leu?Ala?Ser?Asp?Leu

1 5

ggt?att?aag?ttc?gtc?gca?gtg?gtg?gat?aaa?gat?cta?gag?act?gct?gag 163

Gly?Ile?Lys?Phe?Val?Ala?Val?Val?Asp?Lys?Asp?Leu?Glu?Thr?Ala?Glu

10 15 20

aaa?ttt?gcg?acg?gga?ctt?gga?gct?gct?ggc?gat?tct?tca?gaa?agc?agc 211

Lys?Phe?Ala?Thr?Gly?Leu?Gly?Ala?Ala?Gly?Asp?Ser?Ser?Glu?Ser?Ser

25 30 35

gtc?aag?gcc?cac?ggc?agc?ctg?ccg?gct?ttg?ttc?tcc?aaa?aag?aag?atc 259

Val?Lys?Ala?His?Gly?Ser?Leu?Pro?Ala?Leu?Phe?Ser?Lys?Lys?Lys?Ile

40 45 50

gat?gtt?cta?cac?atc?acc?acc?ccc?cac?gac?caa?cac?att?ggt?ttg?gct 307

Asp?Val?Leu?His?Ile?Thr?Thr?Pro?His?Asp?Gln?His?Ile?Gly?Leu?Ala

55 60 65

ctc?gaa?gcg?cta?cac?cac?ggt?gta?aat?gtc?atc?ctg?gaa?aag?ccg?ttg 355

Leu?Glu?Ala?Leu?His?His?Gly?Val?Asn?Val?Ile?Leu?Glu?Lys?Pro?Leu

70 75 80 85

gct?aat?gag?ttg?gac?cag?gcg?cag?cgt?ctc?atc?gac?tac?ttg?gat?gaa 403

Ala?Asn?Glu?Leu?Asp?Gln?Ala?Gln?Arg?Leu?Ile?Asp?Tyr?Leu?Asp?Glu

90 95 100

aac?ccc?gat?ggt?cca?aag?att?gca?gtg?tgc?tat?cag?aac?cgt?tac?aac 451

Asn?Pro?Asp?Gly?Pro?Lys?Ile?Ala?Val?Cys?Tyr?Gln?Asn?Arg?Tyr?Asn

105 110 115

gtt?tcc?tcc?cag?gaa?ctg?cgt?cgt?ctg?ctc?gat?tca?ggt?gac?ctc?ggt 499

Val?Ser?Ser?Gln?Glu?Leu?Arg?Arg?Leu?Leu?Asp?Ser?Gly?Asp?Leu?Gly

120 125 130

gcc?atc?aat?ggt?gca?tat?tcc?tct?gtg?gtg?tgg?acc?cgc?acc?cca?ggc 547

Ala?Ile?Asn?Gly?Ala?Tyr?Ser?Ser?Val?Val?Trp?Thr?Arg?Thr?Pro?Gly

135 140 145

tac?tac?acc?cag?aaa?cct?tgg?cgt?ggc?cag?caa?gca?cac?tcc?ggt?ggt 595

Tyr?Tyr?Thr?Gln?Lys?Pro?Trp?Arg?Gly?Gln?Gln?Ala?His?Ser?Gly?Gly

150 155 160 165

ggc?ctg?ctg?atg?aac?caa?gca?att?cac?acc?ctg?gat?ctg?ctg?cag?tgg 643

Gly?Leu?Leu?Met?Asn?Gln?Ala?Ile?His?Thr?Leu?Asp?Leu?Leu?Gln?Trp

170 175 180

ttc?ctt?gga?aag?gca?aca?gaa?gtc?aag?ggc?act?gtc?tcc?acc?gat?aag 691

Phe?Leu?Gly?Lys?Ala?Thr?Glu?Val?Lys?Gly?Thr?Val?Ser?Thr?Asp?Lys

185 190 195

tat?gcc?gat?gtc?atc?gat?gtt?gaa?gac?acc?gca?cac?gca?tac?atc?ggt 739

Tyr?Ala?Asp?Val?Ile?Asp?Val?Glu?Asp?Thr?Ala?His?Ala?Tyr?Ile?Gly

200 205 210

cac?gag?tcc?gga?gtc?cac?acc?agt?gaa?gtg?agt?tgaaccatgc?tattggtgat?792

His?Glu?Ser?Gly?Val?His?Thr?Ser?Glu?Val?Ser

215 220

aca 795

<210>310

<211>224

<212>PRT

＜213〉Corynebacterium glutamicum

<400>310

Leu?Ala?Ser?Asp?Leu?Gly?Ile?Lys?Phe?Val?Ala?Val?Val?Asp?Lys?Asp

1 5 10 15

Leu?Glu?Thr?Ala?Glu?Lys?Phe?Ala?Thr?Gly?Leu?Gly?Ala?Ala?Gly?Asp

20 25 30

Ser?Ser?Glu?Ser?Ser?Val?Lys?Ala?His?Gly?Ser?Leu?Pro?Ala?Leu?Phe

35 40 45

Ser?Lys?Lys?Lys?Ile?Asp?Val?Leu?His?Ile?Thr?Thr?Pro?His?Asp?Gln

50 55 60

His?Ile?Gly?Leu?Ala?Leu?Glu?Ala?Leu?His?His?Gly?Val?Asn?Val?Ile

65 70 75 80

Leu?Glu?Lys?Pro?Leu?Ala?Asn?Glu?Leu?Asp?Gln?Ala?Gln?Arg?Leu?Ile

85 90 95

Asp?Tyr?Leu?Asp?Glu?Asn?Pro?Asp?Gly?Pro?Lys?Ile?Ala?Val?Cys?Tyr

100 105 110

Gln?Asn?Arg?Tyr?Asn?Val?Ser?Ser?Gln?Glu?Leu?Arg?Arg?Leu?Leu?Asp

115 120 125

Ser?Gly?Asp?Leu?Gly?Ala?Ile?Asn?Gly?Ala?Tyr?Ser?Ser?Val?Val?Trp

130 135 140

Thr?Arg?Thr?Pro?Gly?Tyr?Tyr?Thr?Gln?Lys?Pro?Trp?Arg?Gly?Gln?Gln

145 150 155 160

Ala?His?Ser?Gly?Gly?Gly?Leu?Leu?Met?Asn?Gln?Ala?Ile?His?Thr?Leu

165 170 175

Asp?Leu?Leu?Gln?Trp?Phe?Leu?Gly?Lys?Ala?Thr?Glu?Val?Lys?Gly?Thr

180 185 190

Val?Ser?Thr?Asp?Lys?Tyr?Ala?Asp?Val?Ile?Asp?Val?Glu?Asp?Thr?Ala

195 200 205

His?Ala?Tyr?Ile?Gly?His?Glu?Ser?Gly?Val?His?Thr?Ser?Glu?Val?Ser

210 215 220

<210>311

<211>795

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(772)

<223>FRXA02902

<400>311

catcaacgcc?gagtacaact?aaggacaact?gataatgaca?aatgctgcaa?ttgtcggatg?60

aggagacgtc?gcaaccgttc?atacagaagc?gctggaagct?ttg?gct?tcc?gat?ctt 115

Leu?Ala?Ser?Asp?Leu

1 5

ggt?att?aag?ttc?gtc?gca?gtg?gtg?gat?aaa?gat?cta?gag?act?gct?gag 163

Gly?Ile?Lys?Phe?Val?Ala?Val?Val?Asp?Lys?Asp?Leu?Glu?Thr?Ala?Glu

10 15 20

aaa?ttt?gcg?acg?gga?ctt?gga?gct?gct?ggc?gat?tct?tca?gaa?agc?agc 211

Lys?Phe?Ala?Thr?Gly?Leu?Gly?Ala?Ala?Gly?Asp?Ser?Ser?Glu?Ser?Ser

25 30 35

gtc?aag?gcc?cac?ggc?agc?ctg?ccg?gct?ttg?ttc?tcc?aaa?aag?aag?atc 259

Val?Lys?Ala?His?Gly?Ser?Leu?Pro?Ala?Leu?Phe?Ser?Lys?Lys?Lys?Ile

40 45 50

gat?gtt?cta?cac?atc?acc?acc?ccc?cac?gac?caa?cac?att?ggt?ttg?gct 307

Asp?Val?Leu?His?Ile?Thr?Thr?Pro?His?Asp?Gln?His?Ile?Gly?Leu?Ala

55 60 65

ctc?gaa?gcg?cta?cac?cac?ggt?gta?aat?gtc?atc?ctg?gaa?aag?ccg?ttg 355

Leu?Glu?Ala?Leu?His?His?Gly?Val?Asn?Val?Ile?Leu?Glu?Lys?Pro?Leu

70 75 80 85

gct?aat?gag?ttg?gac?cag?gcg?cag?cgt?ctc?atc?gac?tac?ttg?gat?gaa 403

Ala?Asn?Glu?Leu?Asp?Gln?Ala?Gln?Arg?Leu?Ile?Asp?Tyr?Leu?Asp?Glu

90 95 100

aac?ccc?gat?ggt?cca?aag?att?gca?gtg?tgc?tat?cag?aac?cgt?tac?aac 451

Asn?Pro?Asp?Gly?Pro?Lys?Ile?Ala?Val?Cys?Tyr?Gln?Asn?Arg?Tyr?Asn

105 110 115

gtt?tcc?tcc?cag?gaa?ctg?cgt?cgt?ctg?ctc?gat?tca?ggt?gac?ctc?ggt 499

Val?Ser?Ser?Gln?Glu?Leu?Arg?Arg?Leu?Leu?Asp?Ser?Gly?Asp?Leu?Gly

120 125 130

gcc?atc?aat?ggt?gca?tat?tcc?tct?gtg?gtg?tgg?acc?cgc?acc?cca?ggc 547

Ala?Ile?Asn?Gly?Ala?Tyr?Ser?Ser?Val?Val?Trp?Thr?Arg?Thr?Pro?Gly

135 140 145

tac?tac?acc?cag?aaa?cct?tgg?cgt?ggc?cag?caa?gca?cac?tcc?ggt?ggt 595

Tyr?Tyr?Thr?Gln?Lys?Pro?Trp?Arg?Gly?Gln?Gln?Ala?His?Ser?Gly?Gly

150 155 160 165

ggc?ctg?ctg?atg?aac?caa?gca?att?cac?acc?ctg?gat?ctg?ctg?cag?tgg 643

Gly?Leu?Leu?Met?Asn?Gln?Ala?Ile?His?Thr?Leu?Asp?Leu?Leu?Gln?Trp

170 175 180

ttc?ctt?gga?aag?gca?aca?gaa?gtc?aag?ggc?act?gtc?tcc?acc?gat?aag 691

Phe?Leu?Gly?Lys?Ala?Thr?Glu?Val?Lys?Gly?Thr?Val?Ser?Thr?Asp?Lys

185 190 195

tat?gcc?gat?gtc?atc?gat?gtt?gaa?gac?acc?gca?cac?gca?tac?atc?ggt 739

Tyr?Ala?Asp?Val?Ile?Asp?Val?Glu?Asp?Thr?Ala?His?Ala?Tyr?Ile?Gly

200 205 210

cac?gag?tcc?gga?gtc?cac?acc?agt?gaa?gtg?agt?tgaaccatgc?tattggtgat?792

His?Glu?Ser?Gly?Val?His?Thr?Ser?Glu?Val?Ser

215 220

aca 795

<210>312

<211>224

<212>PRT

＜213〉Corynebacterium glutamicum

<400>312

Leu?Ala?Ser?Asp?Leu?Gly?Ile?Lys?Phe?Val?Ala?Val?Val?Asp?Lys?Asp

1 5 10 15

Leu?Glu?Thr?Ala?Glu?Lys?Phe?Ala?Thr?Gly?Leu?Gly?Ala?Ala?Gly?Asp

20 25 30

Ser?Ser?Glu?Ser?Ser?Val?Lys?Ala?His?Gly?Ser?Leu?Pro?Ala?Leu?Phe

35 40 45

Ser?Lys?Lys?Lys?Ile?Asp?Val?Leu?His?Ile?Thr?Thr?Pro?His?Asp?Gln

50 55 60

His?Ile?Gly?Leu?Ala?Leu?Glu?Ala?Leu?His?His?Gly?Val?Asn?Val?Ile

65 70 75 80

Leu?Glu?Lys?Pro?Leu?Ala?Asn?Glu?Leu?Asp?Gln?Ala?Gln?Arg?Leu?Ile

85 90 95

Asp?Tyr?Leu?Asp?Glu?Asn?Pro?Asp?Gly?Pro?Lys?Ile?Ala?Val?Cys?Tyr

100 105 110

Gln?Asn?Arg?Tyr?Asn?Val?Ser?Ser?Gln?Glu?Leu?Arg?Arg?Leu?Leu?Asp

115 120 125

Ser?Gly?Asp?Leu?Gly?Ala?Ile?Asn?Gly?Ala?Tyr?Ser?Ser?Val?Val?Trp

130 135 140

Thr?Arg?Thr?Pro?Gly?Tyr?Tyr?Thr?Gln?Lys?Pro?Trp?Arg?Gly?Gln?Gln

145 150 155 160

Ala?His?Ser?Gly?Gly?Gly?Leu?Leu?Met?Asn?Gln?Ala?Ile?His?Thr?Leu

165 170 175

Asp?Leu?Leu?Gln?Trp?Phe?Leu?Gly?Lys?Ala?Thr?Glu?Val?Lys?Gly?Thr

180 185 190

Val?Ser?Thr?Asp?Lys?Tyr?Ala?Asp?Val?Ile?Asp?Val?Glu?Asp?Thr?Ala

195 200 205

His?Ala?Tyr?Ile?Gly?His?Glu?Ser?Gly?Val?His?Thr?Ser?Glu?Val?Ser

210 215 220

<210>313

<211>831

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(808)

<223>RXA00251

<400>313

aaccagcgtt?ttcagcgaga?tactggacat?atcaactaaa?atccctgaat?aaaacatcta?60

acatgggttt?tatacagaaa?attcatacga?aaggttgatc?atg?aag?aag?aag?att 115

Met?Lys?Lys?Lys?Ile

1 5

gcg?gtc?gtt?acc?gga?gcg?acc?gga?ggc?atg?gga?att?gag?atc?gtc?aaa 163

Ala?Val?Val?Thr?Gly?Ala?Thr?Gly?Gly?Met?Gly?Ile?Glu?Ile?Val?Lys

10 15 20

gac?ctc?tcc?cgc?gac?cac?att?gtc?tac?gcc?ttg?ggc?cga?aat?cca?gag 211

Asp?Leu?Ser?Arg?Asp?His?Ile?Val?Tyr?Ala?Leu?Gly?Arg?Asn?Pro?Glu

25 30 35

cat?ctg?gca?gct?ctc?gca?gag?atc?gag?gga?gta?gag?cct?atc?gag?tcc 259

His?Leu?Ala?Ala?Leu?Ala?Glu?Ile?Glu?Gly?Val?Glu?Pro?Ile?Glu?Ser

40 45 50

gat?atc?gtg?aag?gaa?gtg?ttg?gaa?gag?gga?ggc?gtc?gac?aag?cta?aaa 307

Asp?Ile?Val?Lys?Glu?Val?Leu?Glu?Glu?Gly?Gly?Val?Asp?Lys?Leu?Lys

55 60 65

aac?ctc?gac?cac?gtg?gat?acg?ctg?gtg?cac?gcc?gcg?gcg?gtg?gcg?cgt 355

Asn?Leu?Asp?His?Val?Asp?Thr?Leu?Val?His?Ala?Ala?Ala?Val?Ala?Arg

70 75 80 85

gac?acg?acc?atc?gaa?gcc?ggc?agt?gtg?gcc?gaa?tgg?cac?gca?cac?ctt 403

Asp?Thr?Thr?Ile?Glu?Ala?Gly?Ser?Val?Ala?Glu?Trp?His?Ala?His?Leu

90 95 100

gat?ctc?aac?gtc?att?gtc?ccg?gcc?gag?ttg?agt?cgc?caa?ctc?ttg?ccc 451

Asp?Leu?Asn?Val?Ile?Val?Pro?Ala?Glu?Leu?Ser?Arg?Gln?Leu?Leu?Pro

105 110 115

gcc?ctc?cgc?gcg?gca?tcc?ggc?tgc?gtc?atc?tac?atc?aac?tcc?ggc?gcc 499

Ala?Leu?Arg?Ala?Ala?Ser?Gly?Cys?Val?Ile?Tyr?Ile?Asn?Ser?Gly?Ala

120 125 130

ggc?aac?gga?cca?cac?ccc?ggc?aac?acc?atc?tac?gcc?gcc?agc?aaa?cac 547

Gly?Asn?Gly?Pro?His?Pro?Gly?Asn?Thr?Ile?Tyr?Ala?Ala?Ser?Lys?His

135 140 145

gcc?ctc?cgc?gga?ctc?gcc?gac?gcc?ttc?cgc?aaa?gaa?gaa?gcc?aac?aac 595

Ala?Leu?Arg?Gly?Leu?Ala?Asp?Ala?Phe?Arg?Lys?Glu?Glu?Ala?Asn?Asn

150 155 160 165

ggc?atc?cgc?gtc?agc?act?gtc?agc?ccc?ggc?ccc?acc?aac?acc?ccc?atg 643

Gly?Ile?Arg?Val?Ser?Thr?Val?Ser?Pro?Gly?Pro?Thr?Asn?Thr?Pro?Met

170 175 180

ctg?caa?ggc?ctc?atg?gac?tca?caa?ggc?acc?aac?ttc?cgc?cca?gag?atc 691

Leu?Gln?Gly?Leu?Met?Asp?Ser?Gln?Gly?Thr?Asn?Phe?Arg?Pro?Glu?Ile

185 190 195

tac?atc?gaa?cca?aaa?gaa?atc?gcc?aac?gca?atc?aga?ttc?gtg?att?gac 739

Tyr?Ile?Glu?Pro?Lys?Glu?Ile?Ala?Asn?Ala?Ile?Arg?Phe?Val?Ile?Asp

200 205 210

gct?ggc?gaa?acc?acc?cag?atc?acc?aac?gtg?gac?gta?cga?cca?cgt?atc 787

Ala?Gly?Glu?Thr?Thr?Gln?Ile?Thr?Asn?Val?Asp?Val?Arg?Pro?Arg?Ile

215 220 225

gaa?ctg?gcg?gac?cgg?aaa?gat?tagttctggg?gggcttcctg?ggc 831

Glu?Leu?Ala?Asp?Arg?Lys?Asp

230 235

<210>314

<211>236

<212>PRT

＜213〉Corynebacterium glutamicum

<400>314

Met?Lys?Lys?Lys?Ile?Ala?Val?Val?Thr?Gly?Ala?Thr?Gly?Gly?Met?Gly

1 5 10 15

Ile?Glu?Ile?Val?Lys?Asp?Leu?Ser?Arg?Asp?His?Ile?Val?Tyr?Ala?Leu

20 25 30

Gly?Arg?Asn?Pro?Glu?His?Leu?Ala?Ala?Leu?Ala?Glu?Ile?Glu?Gly?Val

35 40 45

Glu?Pro?Ile?Glu?Ser?Asp?Ile?Val?Lys?Glu?Val?Leu?Glu?Glu?Gly?Gly

50 55 60

Val?Asp?Lys?Leu?Lys?Asn?Leu?Asp?His?Val?Asp?Thr?Leu?Val?His?Ala

65 70 75 80

Ala?Ala?Val?Ala?Arg?Asp?Thr?Thr?Ile?Glu?Ala?Gly?Ser?Val?Ala?Glu

85 90 95

Trp?His?Ala?His?Leu?Asp?Leu?Asn?Val?Ile?Val?Pro?Ala?Glu?Leu?Ser

100 105 110

Arg?Gln?Leu?Leu?Pro?Ala?Leu?Arg?Ala?Ala?Ser?Gly?Cys?Val?Ile?Tyr

115 120 125

Ile?Asn?Ser?Gly?Ala?Gly?Asn?Gly?Pro?His?Pro?Gly?Asn?Thr?Ile?Tyr

130 135 140

Ala?Ala?Ser?Lys?His?Ala?Leu?Arg?Gly?Leu?Ala?Asp?Ala?Phe?Arg?Lys

145 150 155 160

Glu?Glu?Ala?Asn?Asn?Gly?Ile?Arg?Val?Ser?Thr?Val?Ser?Pro?Gly?Pro

165 170 175

Thr?Asn?Thr?Pro?Met?Leu?Gln?Gly?Leu?Met?Asp?Ser?Gln?Gly?Thr?Asn

180 185 190

Phe?Arg?Pro?Glu?Ile?Tyr?Ile?Glu?Pro?Lys?Glu?Ile?Ala?Asn?Ala?Ile

195 200 205

Arg?Phe?Val?Ile?Asp?Ala?Gly?Glu?Thr?Thr?Gln?Ile?Thr?Asn?Val?Asp

210 215 220

Val?Arg?Pro?Arg?Ile?Glu?Leu?Ala?Asp?Arg?Lys?Asp

225 230 235

<210>315

<211>1008

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(985)

<223>RXN02654

<400>315

tattttcgga?aatttataca?gcaatcctcg?aaatcctaat?aaagatccct?tatcgtggga?60

gaggtacggt?agttcgttcg?aggacaacgt?cgagaaaggc?atg?att?tca?ttg?cta 115

Met?Ile?Ser?Leu?Leu

1 5

aat?gat?cca?cgt?acg?cta?ttc?ccg?aaa?gtc?gat?ccc?cca?aag?caa?agc 163

Asn?Asp?Pro?Arg?Thr?Leu?Phe?Pro?Lys?Val?Asp?Pro?Pro?Lys?Gln?Ser

10 15 20

cag?ccg?gaa?cca?ggc?cta?gat?ata?aaa?ctt?tcc?ccc?caa?gcc?gat?att 211

Gln?Pro?Glu?Pro?Gly?Leu?Asp?Ile?Lys?Leu?Ser?Pro?Gln?Ala?Asp?Ile

25 30 35

ggt?ctc?tcc?agc?tat?caa?gga?agt?gga?agg?ctt?aag?ggc?cgc?aag?gct 259

Gly?Leu?Ser?Ser?Tyr?Gln?Gly?Ser?Gly?Arg?Leu?Lys?Gly?Arg?Lys?Ala

40 45 50

ctt?att?act?ggt?ggc?gat?tct?ggg?att?gga?gct?gcc?gta?gca?atc?gct 307

Leu?Ile?Thr?Gly?Gly?Asp?Ser?Gly?Ile?Gly?Ala?Ala?Val?Ala?Ile?Ala

55 60 65

tat?gct?cgc?gag?ggg?gca?gat?gtt?gcg?atc?gct?tac?ttg?ccc?gaa?gaa 355

Tyr?Ala?Arg?Glu?Gly?Ala?Asp?Val?Ala?Ile?Ala?Tyr?Leu?Pro?Glu?Glu

70 75 80 85

caa?gcc?gat?gct?gac?aga?gtg?ctc?caa?gca?atc?gag?gaa?aca?ggt?caa 403

Gln?Ala?Asp?Ala?Asp?Arg?Val?Leu?Gln?Ala?Ile?Glu?Glu?Thr?Gly?Gln

90 95 100

aaa?gct?ttt?tct?ttc?cct?ggt?gat?ctc?cgt?gat?cca?gaa?tac?tgt?cgc 451

Lys?Ala?Phe?Ser?Phe?Pro?Gly?Asp?Leu?Arg?Asp?Pro?Glu?Tyr?Cys?Arg

105 110 115

tcg?ctg?gtc?caa?gag?acg?gtg?aac?gct?tta?ggt?ggc?cta?gac?atc?ttg 499

Ser?Leu?Va1?Gln?Glu?Thr?Val?Asn?Ala?Leu?Gly?Gly?Leu?Asp?Ile?Leu

120 125 130

gtc?aac?aac?gcg?tca?cgt?cag?gtg?tgg?gca?cct?ggt?ttg?acc?gaa?att 547

Val?Asn?Asn?Ala?Ser?Arg?Gln?Val?Trp?Ala?Pro?Gly?Leu?Thr?Glu?Ile

135 140 145

acc?gac?gaa?aac?ttc?gac?cag?act?ttg?cag?gtt?aac?ctc?tat?ggt?agt 595

Thr?Asp?Glu?Asn?Phe?Asp?Gln?Thr?Leu?Gln?Val?Asn?Leu?Tyr?Gly?Ser

150 155 160 165

ttt?cgg?gtt?acc?aaa?gca?gct?ata?cct?cat?ctg?aag?ccc?gga?tca?tcg 643

Phe?Arg?Val?Thr?Lys?Ala?Ala?Ile?Pro?His?Leu?Lys?Pro?Gly?Ser?Ser

170 175 180

ata?atc?ttt?aca?tcg?tcc?att?cag?gcg?tac?caa?cct?tcg?gaa?acc?ctc 691

Ile?Ile?Phe?Thr?Ser?Ser?Ile?Gln?Ala?Tyr?Gln?Pro?Ser?Glu?Thr?Leu

185 190 195

ttg?gat?tac?gcc?atg?act?aag?gcg?gca?ttg?aac?aat?ttg?tca?aag?ggc 739

Leu?Asp?Tyr?Ala?Met?Thr?Lys?Ala?Ala?Leu?Asn?Asn?Leu?Ser?Lys?Gly

200 205 210

ttg?gca?agt?agt?ctg?ata?ggc?gat?ggc?att?cgg?gta?aat?tct?gta?gcc 787

Leu?Ala?Ser?Ser?Leu?Ile?Gly?Asp?Gly?Ile?Arg?Val?Asn?Ser?Val?Ala

215 220 225

cca?ggt?cct?ttc?tgg?acg?ccg?ttg?caa?ccc?agc?cat?ggt?cag?cca?caa 835

Pro?Gly?Pro?Phe?Trp?Thr?Pro?Leu?Gln?Pro?Ser?His?Gly?Gln?Pro?Gln

230 235 240 245

gag?aaa?ata?gaa?gga?ttt?ggc?cag?cac?gct?ccg?att?gga?aga?gcg?ggt 883

Glu?Lys?Ile?Glu?Gly?Phe?Gly?Gln?His?Ala?Pro?Ile?Gly?Arg?Ala?Gly

250 255 260

cac?cct?gtt?gag?ttg?gca?ggt?gcg?tac?gtt?ttt?ctc?gct?tct?gac?gaa 931

His?Pro?Val?Glu?Leu?Ala?Gly?Ala?Tyr?Val?Phe?Leu?Ala?Ser?Asp?Glu

265 270 275

gcc?agc?tat?gtg?gta?gga?gaa?acc?ctg?gga?gtc?aca?ggt?ggg?acg?ccc 979

Ala?Ser?Tyr?Val?Val?Gly?Glu?Thr?Leu?Gly?Val?Thr?Gly?Gly?Thr?Pro

280 285 290

acc?cca?tagtcggtac?aagcggaatc?act 1008

Thr?Pro

295

<210>316

<211>295

<212>PRT

＜213〉Corynebacterium glutamicum

<400>316

Met?Ile?Ser?Leu?Leu?Asn?Asp?Pro?Arg?Thr?Leu?Phe?Pro?Lys?Val?Asp

1 5 10 15

Pro?Pro?Lys?Gln?Ser?Gln?Pro?Glu?Pro?Gly?Leu?Asp?Ile?Lys?Leu?Ser

20 25 30

Pro?Gln?Ala?Asp?Ile?Gly?Leu?Ser?Ser?Tyr?Gln?Gly?Ser?Gly?Arg?Leu

35 40 45

Lys?Gly?Arg?Lys?Ala?Leu?Ile?Thr?Gly?Gly?Asp?Ser?Gly?Ile?Gly?Ala

50 55 60

Ala?Val?Ala?Ile?Ala?Tyr?Ala?Arg?Glu?Gly?Ala?Asp?Val?Ala?Ile?Ala

65 70 75 80

Tyr?Leu?Pro?Glu?Glu?Gln?Ala?Asp?Ala?Asp?Arg?Val?Leu?Gln?Ala?Ile

85 90 95

Glu?Glu?Thr?Gly?Gln?Lys?Ala?Phe?Ser?Phe?Pro?Gly?Asp?Leu?Arg?Asp

100 105 110

Pro?Glu?Tyr?Cys?Arg?Ser?Leu?Val?Gln?Glu?Thr?Val?Asn?Ala?Leu?Gly

115 120 125

Gly?Leu?Asp?lle?Leu?Val?Asn?Asn?Ala?Ser?Arg?Gln?Val?Trp?Ala?Pro

130 135 140

Gly?Leu?Thr?Glu?Ile?Thr?Asp?Glu?Asn?Phe?Asp?Gln?Thr?Leu?Gln?Val

145 150 155 160

Asn?Leu?Tyr?Gly?Ser?Phe?Arg?Val?Thr?Lys?Ala?Ala?Ile?Pro?His?Leu

165 170 175

Lys?Pro?Gly?Ser?Ser?Ile?Ile?Phe?Thr?Ser?Ser?Ile?Gln?Ala?Tyr?Gln

180 185 190

Pro?Ser?Glu?Thr?Leu?Leu?Asp?Tyr?Ala?Met?Thr?Lys?Ala?Ala?Leu?Asn

195 200 205

Asn?Leu?Ser?Lys?Gly?Leu?Ala?Ser?Ser?Leu?Ile?Gly?Asp?Gly?Ile?Arg

210 215 220

Val?Asn?Ser?Val?Ala?Pro?Gly?Pro?Phe?Trp?Thr?Pro?Leu?Gln?Pro?Ser

225 230 235 240

His?Gly?Gln?Pro?Gln?Glu?Lys?Ile?Glu?Gly?Phe?Gly?Gln?His?Ala?Pro

245 250 255

Ile?Gly?Arg?Ala?Gly?His?Pro?Val?Glu?Leu?Ala?Gly?Ala?Tyr?Val?Phe

260 265 270

Leu?Ala?Ser?Asp?Glu?Ala?Ser?Tyr?Val?Val?Gly?Glu?Thr?Leu?Gly?Val

275 280 285

Thr?Gly?Gly?Thr?Pro?Thr?Pro

290 295

<210>317

<211>1008

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(985)

<223>FRXA02654

<400>317

tattttcgga?aatttataca?gcaatcctcg?aaatcctaat?aaagatccct?tatcgtggga?60

gaggtacggt?agttcgttcg?aggacaacgt?cgagaaaggc?atg?att?tca?ttg?cta 115

Met?Ile?Ser?Leu?Leu

1 5

aat?gat?cca?cgt?acg?cta?ttc?ccg?aaa?gtc?gat?ccc?cca?aag?caa?agc 163

Asn?Asp?Pro?Arg?Thr?Leu?Phe?Pro?Lys?Val?Asp?Pro?Pro?Lys?Gln?Ser

10 15 20

cag?ccg?gaa?cca?ggc?cta?gat?ata?aaa?ctt?tcc?ccc?caa?gcc?gat?att 211

Gln?Pro?Glu?Pro?Gly?Leu?Asp?Ile?Lys?Leu?Ser?Pro?Gln?Ala?Asp?Ile

25 30 35

ggt?ctc?tcc?agc?tat?caa?gga?agt?gga?agg?ctt?aag?ggc?cgc?aag?gct 259

Gly?Leu?Ser?Ser?Tyr?Gln?Gly?Ser?Gly?Arg?Leu?Lys?Gly?Arg?Lys?Ala

40 45 50

ctt?att?act?ggt?ggc?gat?tct?ggg?att?gga?gct?gcc?gta?gca?atc?gct 307

Leu?Ile?Thr?Gly?Gly?Asp?Ser?Gly?Ile?Gly?Ala?Ala?Val?Ala?Ile?Ala

55 60 65

tat?gct?cgc?gag?ggg?gca?gat?gtt?gcg?atc?gct?tac?ttg?ccc?gaa?gaa 355

Tyr?Ala?Arg?Glu?Gly?Ala?Asp?Val?Ala?Ile?Ala?Tyr?Leu?Pro?Glu?Glu

70 75 80 85

caa?gcc?gat?gct?gac?aga?gtg?ctc?caa?gca?atc?gag?gaa?aca?ggt?caa 403

Gln?Ala?Asp?Ala?Asp?Arg?Val?Leu?Gln?Ala?Ile?Glu?Glu?Thr?Gly?Gln

90 95 100

aaa?gct?ttt?tct?ttc?cct?ggt?gat?ctc?cgt?gat?cca?gaa?tac?tgt?cgc 451

Lys?Ala?Phe?Ser?Phe?Pro?Gly?Asp?Leu?Arg?Asp?Pro?Glu?Tyr?Cys?Arg

105 110 115

tcg?ctg?gtc?caa?gag?acg?gtg?aac?gct?tta?ggt?ggc?cta?gac?atc?ttg 499

Ser?Leu?Val?Gln?Glu?Thr?Val?Asn?Ala?Leu?Gly?Gly?Leu?Asp?Ile?Leu

120 125 130

gtc?aac?aac?gcg?tca?cgt?cag?gtg?tgg?gca?cct?ggt?ttg?acc?gaa?att 547

Val?Asn?Asn?Ala?Ser?Arg?Gln?Val?Trp?Ala?Pro?Gly?Leu?Thr?Glu?Ile

135 140 145

acc?gac?gaa?aac?ttc?gac?cag?act?ttg?cag?gtt?aac?ctc?tat?ggt?agt 595

Thr?Asp?Glu?Asn?Phe?Asp?Gln?Thr?Leu?Gln?Val?Asn?Leu?Tyr?Gly?Ser

150 155 160 165

ttt?cgg?gtt?acc?aaa?gca?gct?ata?cct?cat?ctg?aag?ccc?gga?tca?tcg 643

Phe?Arg?Val?Thr?Lys?Ala?Ala?Ile?Pro?His?Leu?Lys?Pro?Gly?Ser?Ser

170 175 180

ata?atc?ttt?aca?tcg?tcc?att?cag?gcg?tac?caa?cct?tcg?gaa?acc?ctc 691

Ile?Ile?Phe?Thr?Ser?Ser?Ile?Gln?Ala?Tyr?Gln?Pro?Ser?Glu?Thr?Leu

185 190 195

ttg?gat?tac?gcc?atg?act?aag?gcg?gca?ttg?aac?aat?ttg?tca?aag?ggc 739

Leu?Asp?Tyr?Ala?Met?Thr?Lys?Ala?Ala?Leu?Asn?Asn?Leu?Ser?Lys?Gly

200 205 210

ttg?gca?agt?agt?ctg?ata?ggc?gat?ggc?att?cgg?gta?aat?tct?gta?gcc 787

Leu?Ala?Ser?Ser?Leu?Ile?Gly?Asp?Gly?Ile?Arg?Val?Asn?Ser?Val?Ala

215 220 225

cca?ggt?cct?ttc?tgg?acg?ccg?ttg?caa?ccc?agc?cat?ggt?cag?cca?caa 835

Pro?Gly?Pro?Phe?Trp?Thr?Pro?Leu?Gln?Pro?Ser?His?Gly?Gln?Pro?Gln

230 235 240 245

gag?aaa?ata?gaa?gga?ttt?ggc?cag?cac?gct?ccg?att?gga?aga?gcg?ggt 883

Glu?Lys?Ile?Glu?Gly?Phe?Gly?Gln?His?Ala?Pro?Ile?Gly?Arg?Ala?Gly

250 255 260

cac?cct?gtt?gag?ttg?gca?ggt?gcg?tac?gtt?ttt?ctc?gct?tct?gac?gaa 931

His?Pro?Val?Glu?Leu?Ala?Gly?Ala?Tyr?Val?Phe?Leu?Ala?Ser?Asp?Glu

265 270 275

gcc?agc?tat?gtg?gta?gga?gaa?acc?ctg?gga?gtc?aca?ggt?ggg?acg?ccc 979

Ala?Ser?Tyr?Val?Val?Gly?Glu?Thr?Leu?Gly?Val?Thr?Gly?Gly?Thr?Pro

280 285 290

acc?cca?tagtcggtac?aagcggaatc?act 1008

Thr?Pro

295

<210>318

<211>295

<212>PRT

＜213〉Corynebacterium glutamicum

<400>318

Met?Ile?Ser?Leu?Leu?Asn?Asp?Pro?Arg?Thr?Leu?Phe?Pro?Lys?Val?Asp

1 5 10 15

Pro?Pro?Lys?Gln?Ser?Gln?Pro?Glu?Pro?Gly?Leu?Asp?Ile?Lys?Leu?Ser

20 25 30

Pro?Gln?Ala?Asp?Ile?Gly?Leu?Ser?Ser?Tyr?Gln?Gly?Ser?Gly?Arg?Leu

35 40 45

Lys?Gly?Arg?Lys?Ala?Leu?Ile?Thr?Gly?Gly?Asp?Ser?Gly?Ile?Gly?Ala

50 55 60

Ala?Val?Ala?Ile?Ala?Tyr?Ala?Arg?Glu?Gly?Ala?Asp?Val?Ala?Ile?Ala

65 70 75 80

Tyr?Leu?Pro?Glu?Glu?Gln?Ala?Asp?Ala?Asp?Arg?Val?Leu?Gln?Ala?Ile

85 90 95

Glu?Glu?Thr?Gly?Gln?Lys?Ala?Phe?Ser?Phe?Pro?Gly?Asp?Leu?Arg?Asp

100 105 110

Pro?Glu?Tyr?Cys?Arg?Ser?Leu?Val?Gln?Glu?Thr?Val?Asn?Ala?Leu?Gly

115 120 125

Gly?Leu?Asp?Ile?Leu?Val?Asn?Asn?Ala?Ser?Arg?Gln?Val?Trp?Ala?Pro

130 135 140

Gly?Leu?Thr?Glu?Ile?Thr?Asp?Glu?Asn?Phe?Asp?Gln?Thr?Leu?Gln?Val

145 150 155 160

Asn?Leu?Tyr?Gly?Ser?Phe?Arg?Val?Thr?Lys?Ala?Ala?Ile?Pro?His?Leu

165 170 175

Lys?Pro?Gly?Ser?Ser?Ile?Ile?Phe?Thr?Ser?Ser?Ile?Gln?Ala?Tyr?Gln

180 185 190

Pro?Ser?Glu?Thr?Leu?Leu?Asp?Tyr?Ala?Met?Thr?Lys?Ala?Ala?Leu?Asn

195 200 205

Asn?Leu?Ser?Lys?Gly?Leu?Ala?Ser?Ser?Leu?Ile?Gly?Asp?Gly?Ile?Arg

210 215 220

Val?Asn?Ser?Val?Ala?Pro?Gly?Pro?Phe?Trp?Thr?Pro?Leu?Gln?Pro?Ser

225 230 235 240

His?Gly?Gln?Pro?Gln?Glu?Lys?Ile?Glu?Gly?Phe?Gly?Gln?His?Ala?Pro

245 250 255

Ile?Gly?Arg?Ala?Gly?His?Pro?Val?Glu?Leu?Ala?Gly?Ala?Tyr?Val?Phe

260 265 270

Leu?Ala?Ser?Asp?Glu?Ala?Ser?Tyr?Val?Val?Gly?Glu?Thr?Leu?Gly?Val

275 280 285

Thr?Gly?Gly?Thr?Pro?Thr?Pro

290 295

<210>319

<211>1605

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1582)

<223>RXN01049

<400>319

aagcacagca?attgagcaat?actcccatgc?atgttttcgc?gtgatcacgc?tatatcctta?60

aagaatattc?tttattagtc?agacctttaa?aggaaacctt?atg?gga?tca?att?cca 115

Met?Gly?Ser?Ile?Pro

1 5

aca?atg?tcc?atc?cct?ttt?gat?gac?tca?cgt?gga?cct?tat?gtc?ctt?gct 163

Thr?Met?Ser?Ile?Pro?Phe?Asp?Asp?Ser?Arg?Gly?Pro?Tyr?Val?Leu?Ala

10 15 20

atg?gat?att?ggt?tcc?act?gca?tca?cga?ggt?gga?ctt?tat?gat?gct?tcc 211

Met?Asp?Ile?Gly?Ser?Thr?Ala?Ser?Arg?Gly?Gly?Leu?Tyr?Asp?Ala?Ser

25 30 35

ggc?tgc?cca?atc?aaa?ggc?acc?aag?cag?cgc?gaa?tcc?cat?gaa?ttc?acc 259

Gly?Cys?Pro?Ile?Lys?Gly?Thr?Lys?Gln?Arg?Glu?Ser?His?Glu?Phe?Thr

40 45 50

acc?ggt?gag?ggc?gtt?tcc?acc?att?gat?gct?gac?cag?gtg?gtt?tcg?gag 307

Thr?Gly?Glu?Gly?Val?Ser?Thr?Ile?Asp?Ala?Asp?Gln?Val?Val?Ser?Glu

55 60 65

atc?acc?tca?gtt?att?aat?ggc?att?ttg?aac?gcg?gct?gat?cat?cac?aac 355

Ile?Thr?Ser?Val?Ile?Asn?Gly?Ile?Leu?Asn?Ala?Ala?Asp?His?His?Asn

70 75 80 85

atc?aaa?gat?cag?atc?gcc?gct?gtc?gcg?cta?gat?tct?ttt?gca?tcc?tca 403

Ile?Lys?Asp?Gln?Ile?Ala?Ala?Val?Ala?Leu?Asp?Ser?Phe?Ala?Ser?Ser

90 95 100

tta?atc?ttg?gtc?gat?ggt?gaa?ggc?aat?gcg?ctc?acc?ccg?tgc?att?acc 451

Leu?Ile?Leu?Val?Asp?Gly?Glu?Gly?Asn?Ala?Leu?Thr?Pro?Cys?Ile?Thr

105 110 115

tac?gcg?gat?tct?cgt?tct?gca?cag?tat?gtg?gag?cag?ctg?cgc?gcg?gaa 499

Tyr?Ala?Asp?Ser?Arg?Ser?Ala?Gln?Tyr?Val?Glu?Gln?Leu?Arg?Ala?Glu

120 125 130

atc?gat?gag?aag?gcc?tac?cac?ggc?cgc?acc?ggc?gtc?tgc?ttg?cac?acc 547

Ile?Asp?Glu?Lys?Ala?Tyr?His?Gly?Arg?Thr?Gly?Val?Cys?Leu?His?Thr

135 140 145

tcc?tac?cac?cca?tcg?cgc?ttg?ctg?tgg?ctg?aaa?act?gag?ttc?gag?aaa 595

Ser?Tyr?His?Pro?Ser?Arg?Leu?Leu?Trp?Leu?Lys?Thr?Glu?Phe?Glu?Lys

150 155 160 165

gag?ttc?aac?aaa?gcc?aag?tat?gtg?atg?acc?atc?ggt?gag?tac?gtc?tac 643

Glu?Phe?Asn?Lys?Ala?Lys?Tyr?Val?Met?Thr?Ile?Gly?Glu?Tyr?Val?Tyr

170 175 180

ttc?aaa?ctt?gca?ggc?atc?acc?gga?atg?gct?act?tcg?att?gcc?gcg?tgg 691

Phe?Lys?Leu?Ala?Gly?Ile?Thr?Gly?Met?Ala?Thr?Ser?Ile?Ala?Ala?Trp

185 190 195

agt?ggc?att?ttg?gac?gcc?cat?acc?ggc?gaa?ctt?gat?ctg?act?atc?ttg 739

Ser?Gly?Ile?Leu?Asp?Ala?His?Thr?Gly?Glu?Leu?Asp?Leu?Thr?Ile?Leu

200 205 210

gag?cac?atc?ggt?gtt?gat?ccg?gct?ctg?ttc?ggt?gag?atc?aga?aac?cct 787

Glu?His?Ile?Gly?Val?Asp?Pro?Ala?Leu?Phe?Gly?Glu?Ile?Arg?Asn?Pro

215 220 225

gat?gaa?cca?gcc?acc?gat?gcc?aaa?gtt?gtc?gac?aaa?aag?tgg?aag?cac 835

Asp?Glu?Pro?Ala?Thr?Asp?Ala?Lys?Val?Val?Asp?Lys?Lys?Trp?Lys?His

230 235 240 245

ctg?gaa?gaa?atc?cct?tgg?ttc?cat?gcc?att?cca?gac?ggc?tgg?cct?tcc 883

Leu?Glu?Glu?Ile?Pro?Trp?Phe?His?Ala?Ile?Pro?Asp?Gly?Trp?Pro?Ser

250 255 260

aac?att?ggc?cca?ggc?gcc?gtg?gat?tct?aaa?acc?gtc?gca?gtc?gcc?gcc 931

Asn?Ile?Gly?Pro?Gly?Ala?Val?Asp?Ser?Lys?Thr?Val?Ala?Val?Ala?Ala

265 270 275

gct?aca?tcc?ggc?gcc?atg?cgc?gtg?atc?ctt?ccg?agc?gtt?ccc?gaa?cag 979

Ala?Thr?Ser?Gly?Ala?Met?Arg?Val?Ile?Leu?Pro?Ser?Val?Pro?Glu?Gln

280 285 290

atc?ccc?tct?ggc?ctg?tgg?tgt?tac?cgc?gtt?tcc?cgc?gac?cag?tgc?atc 1027

Ile?Pro?Ser?Gly?Leu?Trp?Cys?Tyr?Arg?Val?Ser?Arg?Asp?Gln?Cys?Ile

295 300 305

gtt?ggt?ggc?gca?ctc?aac?gac?gtc?gga?cgc?gcc?gtc?acc?tgg?ctg?gaa 1075

Val?Gly?Gly?Ala?Leu?Asn?Asp?Val?Gly?Arg?Ala?Val?Thr?Trp?Leu?Glu

310 315 320 325

cgc?acc?att?atc?aag?cct?gaa?aac?ctc?gac?gaa?gtg?ctg?atc?cgc?gaa 1123

Arg?Thr?Ile?Ile?Lys?Pro?Glu?Asn?Leu?Asp?Glu?Val?Leu?Ile?Arg?Glu

330 335 340

ccc?ctc?gaa?ggc?acc?cca?gct?gtc?ctg?ccg?ttc?ttc?tcc?ggg?gaa?cgc 1171

Pro?Leu?Glu?Gly?Thr?Pro?Ala?Val?Leu?Pro?Phe?Phe?Ser?Gly?Glu?Arg

345 350 355

tcc?atc?ggc?tgg?gca?gcc?tca?gcg?cag?gcc?acg?atc?acc?aac?att?cag 1219

Ser?Ile?Gly?Trp?Ala?Ala?Ser?Ala?Gln?Ala?Thr?Ile?Thr?Asn?Ile?Gln

360 365 370

gaa?caa?acc?ggc?cct?gaa?cac?ttg?tgg?cgc?ggc?gtt?ttc?gaa?gcc?ctc 1267

Glu?Gln?Thr?Gly?Pro?Glu?His?Leu?Trp?Arg?Gly?Val?Phe?Glu?Ala?Leu

375 380 385

gca?ctc?tcc?tac?cag?cgc?gtt?tgg?gaa?cac?atg?ggg?aaa?gcc?ggc?gca 1315

Ala?Leu?Ser?Tyr?Gln?Arg?Val?Trp?Glu?His?Met?Gly?Lys?Ala?Gly?Ala

390 395 400 405

gcc?cct?gaa?cgg?gtc?atc?gca?tca?gga?cga?gtc?tcc?acc?gac?cac?cca 1363

Ala?Pro?Glu?Arg?Val?Ile?Ala?Ser?Gly?Arg?Val?Ser?Thr?Asp?His?Pro

410 415 420

gaa?ttc?ctc?gcg?atg?ctt?tcc?gac?gcc?ctc?gac?acc?cca?gtc?atc?cct 1411

Glu?Phe?Leu?Ala?Met?Leu?Ser?Asp?Ala?Leu?Asp?Thr?Pro?Val?Ile?Pro

425 430 435

ctg?gaa?atg?aag?cgc?gcc?acc?ctc?cgc?ggc?acc?gca?ctt?atc?gtc?ctt 1459

Leu?Glu?Met?Lys?Arg?Ala?Thr?Leu?Arg?Gly?Thr?Ala?Leu?Ile?Val?Leu

440 445 450

gag?cag?ctc?gaa?cca?ggc?ggc?acg?cgc?gcg?acg?cca?cca?ttc?ggc?acg 1507

Glu?Gln?Leu?Glu?Pro?Gly?Gly?Thr?Arg?Ala?Thr?Pro?Pro?Phe?Gly?Thr

455 460 465

acg?cat?cag?ccg?cgc?ttt?gcg?cac?cat?tac?tcc?aag?gca?aga?gag?ctt 1555

Thr?His?Gln?Pro?Arg?Phe?Ala?His?His?Tyr?Ser?Lys?Ala?Arg?Glu?Leu

470 475 480 485

ttc?gac?gcc?ctc?tac?ctc?aag?ttg?gtc?tagcttttcg?cagtggaacg 1602

Phe?Asp?Ala?Leu?Tyr?Leu?Lys?Leu?Val

490

cgc 1605

<210>320

<211>494

<212>PRT

＜213〉Corynebacterium glutamicum

<400>320

Met?Gly?Ser?Ile?Pro?Thr?Met?Ser?Ile?Pro?Phe?Asp?Asp?Ser?Arg?Gly

1 5 10 15

Pro?Tyr?Val?Leu?Ala?Met?Asp?Ile?Gly?Ser?Thr?Ala?Ser?Arg?Gly?Gly

20 25 30

Leu?Tyr?Asp?Ala?Ser?Gly?Cys?Pro?Ile?Lys?Gly?Thr?Lys?Gln?Arg?Glu

35 40 45

Ser?His?Glu?Phe?Thr?Thr?Gly?Glu?Gly?Val?Ser?Thr?Ile?Asp?Ala?Asp

50 55 60

Gln?Val?Val?Ser?Glu?Ile?Thr?Ser?Val?lle?Asn?Gly?Ile?Leu?Asn?Ala

65 70 75 80

Ala?Asp?His?His?Asn?Ile?Lys?Asp?Gln?Ile?Ala?Ala?Val?Ala?Leu?Asp

85 90 95

Ser?Phe?Ala?Ser?Ser?Leu?Ile?Leu?Val?Asp?Gly?Glu?Gly?Asn?Ala?Leu

100 105 110

Thr?Pro?Cys?Ile?Thr?Tyr?Ala?Asp?Ser?Arg?Ser?Ala?Gln?Tyr?Val?Glu

115 120 125

Gln?Leu?Arg?Ala?Glu?Ile?Asp?Glu?Lys?Ala?Tyr?His?Gly?Arg?Thr?Gly

130 135 140

Val?Cys?Leu?His?Thr?Ser?Tyr?His?Pro?Ser?Arg?Leu?Leu?Trp?Leu?Lys

145 150 155 160

Thr?Glu?Phe?Glu?Lys?Glu?Phe?Asn?Lys?Ala?Lys?Tyr?Val?Met?Thr?Ile

165 170 175

Gly?Glu?Tyr?Val?Tyr?Phe?Lys?Leu?Ala?Gly?Ile?Thr?Gly?Met?Ala?Thr

180 185 190

Ser?Ile?Ala?Ala?Trp?Ser?Gly?Ile?Leu?Asp?Ala?His?Thr?Gly?Glu?Leu

195 200 205

Asp?Leu?Thr?Ile?Leu?Glu?His?Ile?Gly?Val?Asp?Pro?Ala?Leu?Phe?Gly

210 215 220

Glu?Ile?Arg?Asn?Pro?Asp?Glu?Pro?Ala?Thr?Asp?Ala?Lys?Val?Val?Asp

225 230 235 240

Lys?Lys?Trp?Lys?His?Leu?Glu?Glu?Ile?Pro?Trp?Phe?His?Ala?Ile?Pro

245 250 255

Asp?Gly?Trp?Pro?Ser?Asn?Ile?Gly?Pro?Gly?Ala?Val?Asp?Ser?Lys?Thr

260 265 270

Val?Ala?Val?Ala?Ala?Ala?Thr?Ser?Gly?Ala?Met?Arg?Val?Ile?Leu?Pro

275 280 285

Ser?Val?Pro?Glu?Gln?Ile?Pro?Ser?Gly?Leu?Trp?Cys?Tyr?Arg?Val?Ser

290 295 300

Arg?Asp?Gln?Cys?Ile?Val?Gly?Gly?Ala?Leu?Asn?Asp?Val?Gly?Arg?Ala

305 310 315 320

Val?Thr?Trp?Leu?Glu?Arg?Thr?Ile?Ile?Lys?Pro?Glu?Asn?Leu?Asp?Glu

325 330 335

Val?Leu?Ile?Arg?Glu?Pro?Leu?Glu?Gly?Thr?Pro?Ala?Val?Leu?Pro?Phe

340 345 350

Phe?Ser?Gly?Glu?Arg?Ser?Ile?Gly?Trp?Ala?Ala?Ser?Ala?Gln?Ala?Thr

355 360 365

Ile?Thr?Asn?Ile?Gln?Glu?Gln?Thr?Gly?Pro?Glu?His?Leu?Trp?Arg?Gly

370 375 380

Val?Phe?Glu?Ala?Leu?Ala?Leu?Ser?Tyr?Gln?Arg?Val?Trp?Glu?His?Met

385 390 395 400

Gly?Lys?Ala?Gly?Ala?Ala?Pro?Glu?Arg?Val?Ile?Ala?Ser?Gly?Arg?Val

405 410 415

Ser?Thr?Asp?His?Pro?Glu?Phe?Leu?Ala?Met?Leu?Ser?Asp?Ala?Leu?Asp

420 425 430

Thr?Pro?Val?Ile?Pro?Leu?Glu?Met?Lys?Arg?Ala?Thr?Leu?Arg?Gly?Thr

435 440 445

Ala?Leu?Ile?Val?Leu?Glu?Gln?Leu?Glu?Pro?Gly?Gly?Thr?Arg?Ala?Thr

450 455 460

Pro?Pro?Phe?Gly?Thr?Thr?His?Gln?Pro?Arg?Phe?Ala?His?His?Tyr?Ser

465 470 475 480

Lys?Ala?Arg?Glu?Leu?Phe?Asp?Ala?Leu?Tyr?Leu?Lys?Leu?Val

485 490

<210>321

<211>1134

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1111)

<223>FRXA01049

<400>321

cacagtatgt?ggagcagctg?cgcgcggaaa?tcgatgagaa?ggcctaccac?ggccgcaccg?60

gcgtctgctt?gcacacctcc?taccacccat?cgcgcttgct?gtg?gtg?aaa?act?gag 115

Val?Val?Lys?Thr?Glu

1 5

ttc?gag?aaa?gag?ttc?aac?aaa?gcc?aag?tat?gtg?atg?acc?atc?ggt?gag 163

Phe?Glu?Lys?Glu?Phe?Asn?Lys?Ala?Lys?Tyr?Val?Met?Thr?Ile?Gly?Glu

10 15 20

tac?gtc?tac?ttc?aaa?ctt?gca?ggc?atc?acc?gga?atg?gct?act?tcg?att 211

Tyr?Val?Tyr?Phe?Lys?Leu?Ala?Gly?Ile?Thr?Gly?Met?Ala?Thr?Ser?Ile

25 30 35

gcc?gcg?tgg?agt?ggc?att?ttg?gac?gcc?cat?acc?ggc?gaa?ctt?gat?ctg 259

Ala?Ala?Trp?Ser?Gly?Ile?Leu?Asp?Ala?His?Thr?Gly?Glu?Leu?Asp?Leu

40 45 50

act?atc?ttg?gag?cac?atc?ggt?gtt?gat?ccg?gct?ctg?ttc?ggt?gag?atc 307

Thr?Ile?Leu?Glu?His?Ile?Gly?Val?Asp?Pro?Ala?Leu?Phe?Gly?Glu?Ile

55 60 65

aga?aac?cct?gat?gaa?cca?gcc?acc?gat?gcc?aaa?gtt?gtc?gac?aaa?aag 355

Arg?Asn?Pro?Asp?Glu?Pro?Ala?Thr?Asp?Ala?Lys?Val?Val?Asp?Lys?Lys

70 75 80 85

tgg?aag?cac?ctg?gaa?gaa?atc?cct?tgg?ttc?cat?gcc?att?cca?gac?ggc 403

Trp?Lys?His?Leu?Glu?Glu?Ile?Pro?Trp?Phe?His?Ala?Ile?Pro?Asp?Gly

90 95 100

tgg?cct?tcc?aac?att?ggc?cca?ggc?gcc?gtg?gat?tct?aaa?acc?gtc?gca 451

Trp?Pro?Ser?Asn?Ile?Gly?Pro?Gly?Ala?Val?Asp?Ser?Lys?Thr?Val?Ala

105 110 115

gtc?gcc?gcc?gct?aca?tcc?ggc?gcc?atg?cgc?gtg?atc?ctt?ccg?agc?gtt 499

Val?Ala?Ala?Ala?Thr?Ser?Gly?Ala?Met?Arg?Val?Ile?Leu?Pro?Ser?Val

120 125 130

ccc?gaa?cag?atc?ccc?tct?ggc?ctg?tgg?tgt?tac?cgc?gtt?tcc?cgc?gac 547

Pro?Glu?Gln?Ile?Pro?Ser?Gly?Leu?Trp?Cys?Tyr?Arg?Val?Ser?Arg?Asp

135 140 145

cag?tgc?atc?gtt?ggt?ggc?gca?ctc?aac?gac?gtc?gga?cgc?gcc?gtc?acc 595

Gln?Cys?Ile?Val?Gly?Gly?Ala?Leu?Asn?Asp?Val?Gly?Arg?Ala?Val?Thr

150 155 160 165

tgg?ctg?gaa?cgc?acc?att?atc?aag?cct?gaa?aac?ctc?gac?gaa?gtg?ctg 643

Trp?Leu?Glu?Arg?Thr?Ile?Ile?Lys?Pro?Glu?Asn?Leu?Asp?Glu?Val?Leu

170 175 180

atc?cgc?gaa?ccc?ctc?gaa?ggc?acc?cca?gct?gtc?ctg?ccg?ttc?ttc?tcc 691

Ile?Arg?Glu?Pro?Leu?Glu?Gly?Thr?Pro?Ala?Val?Leu?Pro?Phe?Phe?Ser

185 190 195

ggg?gaa?cgc?tcc?atc?ggc?tgg?gca?gcc?tca?gcg?cag?gcc?acg?atc?acc 739

Gly?Glu?Arg?Ser?Ile?Gly?Trp?Ala?Ala?Ser?Ala?Gln?Ala?Thr?Ile?Thr

200 205 210

aac?att?cag?gaa?caa?acc?ggc?cct?gaa?cac?ttg?tgg?cgc?ggc?gtt?ttc 787

Asn?Ile?Gln?Glu?Gln?Thr?Gly?Pro?Glu?His?Leu?Trp?Arg?Gly?Val?Phe

215 220 225

gaa?gcc?ctc?gca?ctc?tcc?tac?cag?cgc?gtt?tgg?gaa?cac?atg?ggg?aaa 835

Glu?Ala?Leu?Ala?Leu?Ser?Tyr?Gln?Arg?Val?Trp?Glu?His?Met?Gly?Lys

230 235 240 245

gcc?ggc?gca?gcc?cct?gaa?cgg?gtc?atc?gca?tca?gga?cga?gtc?tcc?acc 883

Ala?Gly?Ala?Ala?Pro?Glu?Arg?Val?Ile?Ala?Ser?Gly?Arg?Val?Ser?Thr

250 255 260

gac?cac?cca?gaa?ttc?ctc?gcg?atg?ctt?tcc?gac?gcc?ctc?gac?acc?cca 931

Asp?His?Pro?Glu?Phe?Leu?Ala?Met?Leu?Ser?Asp?Ala?Leu?Asp?Thr?Pro

265 270 275

gtc?atc?cct?ctg?gaa?atg?aag?cgc?gcc?acc?ctc?cgc?ggc?acc?gca?ctt 979

Val?Ile?Pro?Leu?Glu?Met?Lys?Arg?Ala?Thr?Leu?Arg?Gly?Thr?Ala?Leu

280 285 290

atc?gtc?ctt?gag?cag?ctc?gaa?cca?ggc?ggc?acg?cgc?gcg?acg?cca?cca 1027

Ile?Val?Leu?Glu?Gln?Leu?Glu?Pro?Gly?Gly?Thr?Arg?Ala?Thr?Pro?Pro

295 300 305

ttc?ggc?acg?acg?cat?cag?ccg?cgc?ttt?gcg?cac?cat?tac?tcc?aag?gca 1075

Phe?Gly?Thr?Thr?His?Gln?Pro?Arg?Phe?Ala?His?His?Tyr?Ser?Lys?Ala

310 315 320 325

aga?gag?ctt?ttc?gac?gcc?ctc?tac?ctc?aag?ttg?gtc?tagcttttcg 1121

Arg?Glu?Leu?Phe?Asp?Ala?Leu?Tyr?Leu?Lys?Leu?Val

330 335

cagtggaacg?cgc 1134

<210>322

<211>337

<212>PRT

＜213〉Corynebacterium glutamicum

<400>322

Val?Val?Lys?Thr?Glu?Phe?Glu?Lys?Glu?Phe?Asn?Lys?Ala?Lys?Tyr?Val

1 5 10 15

Met?Thr?Ile?Gly?Glu?Tyr?Val?Tyr?Phe?Lys?Leu?Ala?Gly?Ile?Thr?Gly

20 25 30

Met?Ala?Thr?Ser?Ile?Ala?Ala?Trp?Ser?Gly?Ile?Leu?Asp?Ala?His?Thr

35 40 45

Gly?Glu?Leu?Asp?Leu?Thr?Ile?Leu?Glu?His?Ile?Gly?Val?Asp?Pro?Ala

50 55 60

Leu?Phe?Gly?Glu?Ile?Arg?Asn?Pro?Asp?Glu?Pro?Ala?Thr?Asp?Ala?Lys

65 70 75 80

Val?Val?Asp?Lys?Lys?Trp?Lys?His?Leu?Glu?Glu?Ile?Pro?Trp?Phe?His

85 90 95

Ala?Ile?Pro?Asp?Gly?Trp?Pro?Ser?Asn?Ile?Gly?Pro?Gly?Ala?Val?Asp

100 105 110

Ser?Lys?Thr?Val?Ala?Val?Ala?Ala?Ala?Thr?Ser?Gly?Ala?Met?Arg?Val

115 120 125

Ile?Leu?Pro?Ser?Val?Pro?Glu?Gln?Ile?Pro?Ser?Gly?Leu?Trp?Cys?Tyr

130 135 140

Arg?Val?Ser?Arg?Asp?Gln?Cys?Ile?Val?Gly?Gly?Ala?Leu?Asn?Asp?Val

145 150 155 160

Gly?Arg?Ala?Val?Thr?Trp?Leu?Glu?Arg?Thr?Ile?Ile?Lys?Pro?Glu?Asn

165 170 175

Leu?Asp?Glu?Val?Leu?Ile?Arg?Glu?Pro?Leu?Glu?Gly?Thr?Pro?Ala?Val

180 185 190

Leu?Pro?Phe?Phe?Ser?Gly?Glu?Arg?Ser?Ile?Gly?Trp?Ala?Ala?Ser?Ala

195 200 205

Gln?Ala?Thr?Ile?Thr?Asn?Ile?Gln?Glu?Gln?Thr?Gly?Pro?Glu?His?Leu

210 215 220

Trp?Arg?Gly?Val?Phe?Glu?Ala?Leu?Ala?Leu?Ser?Tyr?Gln?Arg?Val?Trp

225 230 235 240

Glu?His?Met?Gly?Lys?Ala?Gly?Ala?Ala?Pro?Glu?Arg?Val?Ile?Ala?Ser

245 250 255

Gly?Arg?Val?Ser?Thr?Asp?His?Pro?Glu?Phe?Leu?Ala?Met?Leu?Ser?Asp

260 265 270

Ala?Leu?Asp?Thr?Pro?Val?Ile?Pro?Leu?Glu?Met?Lys?Arg?Ala?Thr?Leu

275 280 285

Arg?Gly?Thr?Ala?Leu?Ile?Val?Leu?Glu?Gln?Leu?Glu?Pro?Gly?Gly?Thr

290 295 300

Arg?Ala?Thr?Pro?Pro?Phe?Gly?Thr?Thr?His?Gln?Pro?Arg?Phe?Ala?His

305 310 315 320

His?Tyr?Ser?Lys?Ala?Arg?Glu?Leu?Phe?Asp?Ala?Leu?Tyr?Leu?Lys?Leu

325 330 335

Val

<210>323

<211>597

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(574)

<223>FRXA01050

<400>323

aagcacagca?attgagcaat?actcccatgc?atgttttcgc?gtgatcacgc?tatatcctta?60

aagaatattc?tttattagtc?agacctttaa?aggaaacctt?atg?gga?tca?att?cca 115

Met?Gly?Ser?Ile?Pro

1 5

aca?atg?tcc?atc?cct?ttt?gat?gac?tca?cgt?gga?cct?tat?gtc?ctt?gct 163

Thr?Met?Ser?Ile?Pro?Phe?Asp?Asp?Ser?Arg?Gly?Pro?Tyr?Val?Leu?Ala

10 15 20

atg?gat?att?ggt?tcc?act?gca?tca?cga?ggt?gga?ctt?tat?gat?gct?tcc 211

Met?Asp?Ile?G1y?Ser?Thr?Ala?Ser?Arg?Gly?Gly?Leu?Tyr?Asp?Ala?Ser

25 30 35

ggc?tgc?cca?atc?aaa?ggc?acc?aag?cag?cgc?gaa?tcc?cat?gaa?ttc?acc 259

Gly?Cys?Pro?Ile?Lys?Gly?Thr?Lys?Gln?Arg?Glu?Ser?His?Glu?Phe?Thr

40 45 50

acc?ggt?gag?ggc?gtt?tcc?acc?att?gat?gct?gac?cag?gtg?gtt?tcg?gag 307

Thr?Gly?Glu?Gly?Val?Ser?Thr?Ile?Asp?Ala?Asp?Gln?Val?Val?Ser?Glu

55 60 65

atc?acc?tca?gtt?att?aat?ggc?att?ttg?aac?gcg?gct?gat?cat?cac?aac 355

Ile?Thr?Ser?Val?Ile?Asn?Gly?Ile?Leu?Asn?Ala?Ala?Asp?His?His?Asn

70 75 80 85

atc?aaa?gat?cag?atc?gcc?gct?gtc?gcg?cta?gat?tct?ttt?gca?tcc?tca 403

Ile?Lys?Asp?Gln?Ile?Ala?Ala?Val?Ala?Leu?Asp?Ser?Phe?Ala?Ser?Ser

90 95 100

tta?atc?ttg?gtc?gat?ggt?gaa?ggc?aat?gcg?ctc?acc?ccg?tgc?att?acc 451

Leu?Ile?Leu?Val?Asp?Gly?Glu?Gly?Asn?Ala?Leu?Thr?Pro?Cys?Ile?Thr

105 110 115

tac?gcg?gat?tct?cgt?tct?gca?cag?tat?gtg?gag?cag?ctg?cgc?gcg?gaa 499

Tyr?Ala?Asp?Ser?Arg?Ser?Ala?Gln?Tyr?Val?Glu?Gln?Leu?Arg?Ala?Glu

120 125 130

atc?gat?gag?aag?gcc?tac?cac?ggc?cgc?acc?ggc?gtc?tgc?ttg?cac?acc 547

Ile?Asp?Glu?Lys?Ala?Tyr?His?Gly?Arg?Thr?Gly?Val?Cys?Leu?His?Thr

135 140 145

tcc?tac?cac?cca?tcg?cgc?ttg?ctg?tgg?tgaaaactga?gttcgagaaa 594

Ser?Tyr?His?Pro?Ser?Arg?Leu?Leu?Trp

150 155

gag 597

<210>324

<211>158

<212>PRT

＜213〉Corynebacterium glutamicum

<400>324

Met?Gly?Ser?Ile?Pro?Thr?Met?Ser?Ile?Pro?Phe?Asp?Asp?Ser?Arg?Gly

1 5 10 15

Pro?Tyr?Val?Leu?Ala?Met?Asp?Ile?Gly?Ser?Thr?Ala?Ser?Arg?Gly?Gly

20 25 30

Leu?Tyr?Asp?Ala?Ser?Gly?Cys?Pro?Ile?Lys?Gly?Thr?Lys?Gln?Arg?Glu

35 40 45

Ser?His?Glu?Phe?Thr?Thr?Gly?Glu?Gly?Val?Ser?Thr?Ile?Asp?Ala?Asp

50 55 60

Gln?Val?Val?Ser?Glu?Ile?Thr?Ser?Val?Ile?Asn?Gly?Ile?Leu?Asn?Ala

65 70 75 80

Ala?Asp?His?His?Asn?Ile?Lys?Asp?Gln?Ile?Ala?Ala?Val?Ala?Leu?Asp

85 90 95

Ser?Phe?Ala?Ser?Ser?Leu?Ile?Leu?Val?Asp?Gly?Glu?Gly?Asn?Ala?Leu

100 105 110

Thr?Pro?Cys?Ile?Thr?Tyr?Ala?Asp?Ser?Arg?Ser?Ala?Gln?Tyr?Val?Glu

115 120 125

Gln?Leu?Arg?Ala?Glu?Ile?Asp?Glu?Lys?Ala?Tyr?His?Gly?Arg?Thr?Gly

130 135 140

Val?Cys?Leu?His?Thr?Ser?Tyr?His?Pro?Ser?Arg?Leu?Leu?Trp

145 150 155

<210>325

<211>1065

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1042)

<223>RXA00202

<400>325

ctggcagcag?attgtcatcg?gttgtgtcat?cgcgcttgcg?gtgggcttcg?atgtcatccg?60

aaacaaaacc?tctaagtaat?tcctgaaagg?aaattttcac?atg?tac?gct?cgt?aaa 115

Met?Tyr?Ala?Arg?Lys

1 5

ctt?att?gct?ctg?tcc?gct?tct?gtc?gtt?ttg?gct?ttc?agc?ttg?tct?gct 163

Leu?Ile?Ala?Leu?Ser?Ala?Ser?Val?Val?Leu?Ala?Phe?Ser?Leu?Ser?Ala

10 15 20

tgc?aac?cgt?gaa?tct?tct?ggc?acc?agc?gca?gac?ggc?ggt?tct?gcg?gat 211

Cys?Asn?Arg?Glu?Ser?Ser?Gly?Thr?Ser?Ala?Asp?Gly?Gly?Ser?Ala?Asp

25 30 35

ggg?tcg?atc?acc?ttg?gct?ctg?tct?acc?cag?acc?aac?ccg?ttc?ttt?gtg 259

Gly?Ser?Ile?Thr?Leu?Ala?Leu?Ser?Thr?Gln?Thr?Asn?Pro?Phe?Phe?Val

40 45 50

cag?ctt?cgt?gat?ggt?gcc?cag?gaa?aag?gct?gat?gaa?ttg?ggc?gtg?acc 307

Gln?Leu?Arg?Asp?Gly?Ala?Gln?Glu?Lys?Ala?Asp?Glu?Leu?Gly?Val?Thr

55 60 65

ctc?aat?gtt?cag?gat?gct?tcc?gat?gac?gct?gca?acg?cag?gcc?aac?cag 355

Leu?Asn?Val?Gln?Asp?Ala?Ser?Asp?Asp?Ala?Ala?Thr?Gln?Ala?Asn?Gln

70 75 80 85

ctc?aac?aac?gct?gtc?acc?acc?ggt?gct?ggc?gtg?gtg?att?gtc?aac?cca 403

Leu?Asn?Asn?Ala?Val?Thr?Thr?Gly?Ala?Gly?Val?Val?Ile?Val?Asn?Pro

90 95 100

act?gat?tct?gat?gct?gtg?gtg?ccg?tcg?gtg?gaa?gct?ctc?aac?cag?gct 451

Thr?Asp?Ser?Asp?Ala?Val?Val?Pro?Ser?Val?Glu?Ala?Leu?Asn?Gln?Ala

105 110 115

gac?att?cct?gtt?gtg?gct?gtc?gac?cgt?tcc?tcc?aat?ggt?ggc?gag?gtg 499

Asp?Ile?Pro?Val?Val?Ala?Val?Asp?Arg?Ser?Ser?Asn?Gly?Gly?Glu?Val

120 125 130

gcg?tcc?ttc?gtg?gca?tct?gac?aac?gtt?gct?ggc?ggc?gcg?cag?gct?gct 547

Ala?Ser?Phe?Val?Ala?Ser?Asp?Asn?Val?Ala?Gly?Gly?Ala?Gln?Ala?Ala

135 140 145

gca?gcc?ctg?gca?gag?gcg?atc?ggt?ggc?gaa?ggt?gaa?atc?ctc?atg?ctg 595

Ala?Ala?Leu?Ala?Glu?Ala?Ile?Gly?Gly?Glu?Gly?Glu?Ile?Leu?Met?Leu

150 155 160 165

caa?ggc?att?gcg?gga?tcc?tct?gca?tca?cgt?gat?cgt?gga?cag?gga?ttt 643

Gln?Gly?Ile?Ala?Gly?Ser?Ser?Ala?Ser?Arg?Asp?Arg?Gly?Gln?Gly?Phe

170 175 180

gaa?gag?gag?atc?gct?aag?cat?gag?ggc?att?tcc?att?gtg?gct?aag?cag 691

Glu?Glu?Glu?Ile?Ala?Lys?His?Glu?Gly?Ile?Ser?Ile?Val?Ala?Lys?Gln

185 190 195

acc?gcc?aac?ttt?gac?cgc?ggt?gag?ggc?ctg?gac?gtg?gca?act?aac?ctg 739

Thr?Ala?Asn?Phe?Asp?Arg?Gly?Glu?Gly?Leu?Asp?Val?Ala?Thr?Asn?Leu

200 205 210

ctg?cag?gca?cac?ccc?aat?gtg?aag?gcg?atc?ttc?gcg?gaa?aac?gat?gag 787

Leu?Gln?Ala?His?Pro?Asn?Val?Lys?Ala?Ile?Phe?Ala?Glu?Asn?Asp?Glu

215 220 225

atg?gcg?ttg?ggc?gca?atc?gaa?gcc?ctg?ggt?gct?cgt?gct?ggt?gaa?gat 835

Met?Ala?Leu?Gly?Ala?Ile?Glu?Ala?Leu?Gly?Ala?Arg?Ala?Gly?Glu?Asp

230 235 240 245

gtc?atc?gtt?gtc?ggt?ttc?gat?ggc?acc?aat?gat?ggt?ctg?gca?gcg?gtt 883

Val?Ile?Val?Val?Gly?Phe?Asp?Gly?Thr?Asn?Asp?Gly?Leu?Ala?Ala?Val

250 255 260

gaa?gat?gga?cgc?atg?ttg?gcc?acc?gtt?gct?cag?cag?cca?gaa?gag?ctg 931

Glu?Asp?Gly?Arg?Met?Leu?Ala?Thr?Val?Ala?Gln?Gln?Pro?Glu?Glu?Leu

265 270 275

gga?gca?aag?gct?gtg?gaa?gaa?gca?gct?aag?ctc?ctg?cgc?ggt?gag?gac 979

Gly?Ala?Lys?Ala?Val?Glu?Glu?Ala?Ala?Lys?Leu?Leu?Arg?Gly?Glu?Asp

280 285 290

gct?gaa?aca?gag?gta?cca?gtt?gag?gtt?gtc?act?gtg?aag?ctc?gac?aac 1027

Ala?Glu?Thr?Glu?Val?Pro?Val?Glu?Val?Val?Thr?Val?Lys?Leu?Asp?Asn

295 300 305

gtc?gcg?gac?ttc?aag?tagtcggcga?tgaaaaagtc?cgt 1065

Val?Ala?Asp?Phe?Lys

310

<210>326

<211>314

<212>PRT

＜213〉Corynebacterium glutamicum

<400>326

Met?Tyr?Ala?Arg?Lys?Leu?Ile?Ala?Leu?Ser?Ala?Ser?Val?Val?Leu?Ala

1 5 10 15

Phe?Ser?Leu?Ser?Ala?Cys?Asn?Arg?Glu?Ser?Ser?Gly?Thr?Ser?Ala?Asp

20 25 30

Gly?Gly?Ser?Ala?Asp?Gly?Ser?Ile?Thr?Leu?Ala?Leu?Ser?Thr?Gln?Thr

35 40 45

Asn?Pro?Phe?Phe?Val?Gln?Leu?Arg?Asp?Gly?Ala?Gln?Glu?Lys?Ala?Asp

50 55 60

Glu?Leu?Gly?Val?Thr?Leu?Asn?Val?Gln?Asp?Ala?Ser?Asp?Asp?Ala?Ala

65 70 75 80

Thr?Gln?Ala?Asn?Gln?Leu?Asn?Asn?Ala?Val?Thr?Thr?Gly?Ala?Gly?Val

85 90 95

Val?Ile?Val?Asn?Pro?Thr?Asp?Ser?Asp?Ala?Val?Val?Pro?Ser?Val?Glu

100 105 110

Ala?Leu?Asn?Gln?Ala?Asp?Ile?Pro?Val?Val?Ala?Val?Asp?Arg?Ser?Ser

115 120 125

Asn?Gly?Gly?Glu?Val?Ala?Ser?Phe?Val?Ala?Ser?Asp?Asn?Val?Ala?Gly

130 135 140

Gly?Ala?Gln?Ala?Ala?Ala?Ala?Leu?Ala?Glu?Ala?Ile?Gly?Gly?Glu?Gly

145 150 155 160

Glu?Ile?Leu?Met?Leu?Gln?Gly?Ile?Ala?Gly?Ser?Ser?Ala?Ser?Arg?Asp

165 170 175

Arg?Gly?Gln?Gly?Phe?Glu?Glu?Glu?Ile?Ala?Lys?His?Glu?Gly?Ile?Ser

180 185 190

Ile?Val?Ala?Lys?Gln?Thr?Ala?Asn?Phe?Asp?Arg?Gly?Glu?Gly?Leu?Asp

195 200 205

Val?Ala?Thr?Asn?Leu?Leu?Gln?Ala?His?Pro?Asn?Val?Lys?Ala?Ile?Phe

210 215 220

Ala?Glu?Asn?Asp?Glu?Met?Ala?Leu?Gly?Ala?Ile?Glu?Ala?Leu?Gly?Ala

225 230 235 240

Arg?Ala?Gly?Glu?Asp?Val?Ile?Val?Val?Gly?Phe?Asp?Gly?Thr?Asn?Asp

245 250 255

Gly?Leu?Ala?Ala?Val?Glu?Asp?Gly?Arg?Met?Leu?Ala?Thr?Val?Ala?Gln

260 265 270

Gln?Pro?Glu?Glu?Leu?Gly?Ala?Lys?Ala?Val?Glu?Glu?Ala?Ala?Lys?Leu

275 280 285

Leu?Arg?Gly?Glu?Asp?Ala?Glu?Thr?Glu?Val?Pro?Val?Glu?Val?Val?Thr

290 295 300

Val?Lys?Leu?Asp?Asn?Val?Ala?Asp?Phe?Lys

305 310

<210>327

<211>1077

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1054)

<223>RXN00872

<400>327

gaaatgtatt?gctttgtcag?gacaatgtgt?tattgtcatg?acatgcgatc?gtgagggtcg?60

ccacattcca?tcaaaaatga?gtgaagggtt?gcatcgccac?atg?act?aac?ttg?acg 115

Met?Thr?Asn?Leu?Thr

1 5

agc?act?cac?gaa?gtc?cta?gct?atc?ggc?cgc?ttg?ggc?gta?gat?att?tac 163

Ser?Thr?His?Glu?Val?Leu?Ala?Ile?Gly?Arg?Leu?Gly?Val?Asp?Ile?Tyr

10 15 20

cca?ctt?caa?agt?gga?gta?gga?ctg?gcc?gat?gtt?caa?tct?ttc?ggc?aag 211

Pro?Leu?Gln?Ser?Gly?Val?Gly?Leu?Ala?Asp?Val?Gln?Ser?Phe?Gly?Lys

25 30 35

tac?ctc?ggc?gga?agc?gca?gca?aac?gtt?tct?gtt?gca?gcc?gcc?cgc?cat 259

Tyr?Leu?Gly?Gly?Ser?Ala?Ala?Asn?Val?Ser?Val?Ala?Ala?Ala?Arg?His

40 45 50

gga?cac?aat?tcc?gca?ctg?ctg?tcc?cgt?gtg?gga?aat?gat?cct?ttc?ggc 307

Gly?His?Asn?Ser?Ala?Leu?Leu?Ser?Arg?Val?Gly?Asn?Asp?Pro?Phe?Gly

55 60 65

gag?tac?ctg?ctt?gct?gag?ctg?gag?cgt?ttg?ggc?gtg?gac?aac?cag?tac 355

Glu?Tyr?Leu?Leu?Ala?Glu?Leu?Glu?Arg?Leu?Gly?Val?Asp?Asn?Gln?Tyr

70 75 80 85

gtt?gcc?acc?gat?cag?act?ttt?aag?acc?cca?gtg?acc?ttc?tgt?gaa?att 403

Val?Ala?Thr?Asp?Gln?Thr?Phe?Lys?Thr?Pro?Val?Thr?Phe?Cys?Glu?Ile

90 95 100

ttc?cca?ccg?gat?gat?ttc?cca?ctg?tac?ttc?tac?cgc?gaa?cca?aag?gct 451

Phe?Pro?Pro?Asp?Asp?Phe?Pro?Leu?Tyr?Phe?Tyr?Arg?Glu?Pro?Lys?Ala

105 110 115

ccg?gat?ctc?aat?att?gaa?tcc?gca?gac?gtc?agc?ctg?gac?gat?gtg?cgc 499

Pro?Asp?Leu?Asn?Ile?Glu?Ser?Ala?Asp?Val?Ser?Leu?Asp?Asp?Val?Arg

120 125 130

gaa?gcc?gat?att?ttg?tgg?ttc?aca?ctc?act?ggt?ttc?agt?gaa?gag?cca 547

Glu?Ala?Asp?Ile?Leu?Trp?Phe?Thr?Leu?Thr?Gly?Phe?Ser?Glu?Glu?Pro

135 140 145

agc?cgc?ggc?aca?cac?cgc?gag?atc?ttg?act?act?cgt?gcg?aac?cgt?cgc 595

Ser?Arg?Gly?Thr?His?Arg?Glu?Ile?Leu?Thr?Thr?Arg?Ala?Asn?Arg?Arg

150 155 160 165

cac?acc?atc?ttt?gat?ctg?gac?tac?cga?cca?atg?ttc?tgg?gaa?tcc?cca 643

His?Thr?Ile?Phe?Asp?Leu?Asp?Tyr?Arg?Pro?Met?Phe?Trp?Glu?Ser?Pro

170 175 180

gaa?gag?gcc?acc?aag?cag?gcg?gaa?tgg?gcg?ttg?cag?cat?tcc?acg?gtg 691

Glu?Glu?Ala?Thr?Lys?Gln?Ala?Glu?Trp?Ala?Leu?Gln?His?Ser?Thr?Val

185 190 195

gcg?gtt?ggc?aac?aag?gaa?gaa?tgc?gaa?atc?gca?gtg?ggc?gag?acc?gag 739

Ala?Val?Gly?Asn?Lys?Glu?Glu?Cys?Glu?Ile?Ala?Val?Gly?Glu?Thr?Glu

200 205 210

cca?gag?cgc?gcg?ggc?cga?gca?ctg?ttg?gaa?cgc?ggt?gtg?gag?ttg?gcc 787

Pro?Glu?Arg?Ala?Gly?Arg?Ala?Leu?Leu?Glu?Arg?Gly?Val?Glu?Leu?Ala

215 220 225

atc?gtc?aag?cag?gga?cct?aag?ggt?gtc?atg?gcg?atg?acc?aag?gac?gaa 835

Ile?Val?Lys?Gln?Gly?Pro?Lys?Gly?Val?Met?Ala?Met?Thr?Lys?Asp?Glu

230 235 240 245

acc?gta?gaa?gtt?cct?ccg?ttc?ttc?gtc?gat?gtc?atc?aac?ggt?ctt?ggt 883

Thr?Val?Glu?Val?Pro?Pro?Phe?Phe?Val?Asp?Val?Ile?Asn?Gly?Leu?Gly

250 255 260

gcc?ggc?gat?gca?ttc?ggc?ggc?gcg?ctg?tgc?cac?ggt?ctg?ctc?tct?gaa 931

Ala?Gly?Asp?Ala?Phe?Gly?Gly?Ala?Leu?Cys?His?Gly?Leu?Leu?Ser?Glu

265 270 275

tgg?ccg?ttg?gaa?aag?gtt?ctc?cgt?ttt?gcc?aac?acc?gcg?ggt?gcg?ctt 979

Trp?Pro?Leu?Glu?Lys?Val?Leu?Arg?Phe?Ala?Asn?Thr?Ala?Gly?Ala?Leu

280 285 290

gtg?gcg?tcc?cgt?ctt?gaa?tgc?tcc?acc?gca?atg?cct?act?acc?gat?gag 1027

Val?Ala?Ser?Arg?Leu?Glu?Cys?Ser?Thr?Ala?Met?Pro?Thr?Thr?Asp?Glu

295 300 305

gtg?gaa?gcc?tcc?ctc?aac?cag?aaa?gtc?tgatatgact?cctccgatta 1074

Val?Glu?Ala?Ser?Leu?Asn?Gln?Lys?Val

310 315

tct 1077

<210>328

<211>318

<212>PRT

＜213〉Corynebacterium glutamicum

<400>328

Met?Thr?Asn?Leu?Thr?Ser?Thr?His?Glu?Val?Leu?Ala?Ile?Gly?Arg?Leu

1 5 10 15

Gly?Val?Asp?Ile?Tyr?Pro?Leu?Gln?Ser?Gly?Val?Gly?Leu?Ala?Asp?Val

20 25 30

Gln?Ser?Phe?Gly?Lys?Tyr?Leu?Gly?Gly?Ser?Ala?Ala?Asn?Val?Ser?Val

35 40 45

Ala?Ala?Ala?Arg?His?Gly?His?Asn?Ser?Ala?Leu?Leu?Ser?Arg?Val?Gly

50 55 60

Asn?Asp?Pro?Phe?Gly?Glu?Tyr?Leu?Leu?Ala?Glu?Leu?Glu?Arg?Leu?Gly

65 70 75 80

Val?Asp?Asn?Gln?Tyr?Val?Ala?Thr?Asp?Gln?Thr?Phe?Lys?Thr?Pro?Val

85 90 95

Thr?Phe?Cys?Glu?Ile?Phe?Pro?Pro?Asp?Asp?Phe?Pro?Leu?Tyr?Phe?Tyr

100 105 110

Arg?Glu?Pro?Lys?Ala?Pro?Asp?Leu?Asn?Ile?Glu?Ser?Ala?Asp?Val?Ser

115 120 125

Leu?Asp?Asp?Val?Arg?Glu?Ala?Asp?Ile?Leu?Trp?Phe?Thr?Leu?Thr?Gly

130 135 140

Phe?Ser?Glu?Glu?Pro?Ser?Arg?Gly?Thr?His?Arg?Glu?Ile?Leu?Thr?Thr

145 150 155 160

Arg?Ala?Asn?Arg?Arg?His?Thr?Ile?Phe?Asp?Leu?Asp?Tyr?Arg?Pro?Met

165 170 175

Phe?Trp?Glu?Ser?Pro?Glu?Glu?Ala?Thr?Lys?Gln?Ala?Glu?Trp?Ala?Leu

180 185 190

Gln?His?Ser?Thr?Val?Ala?Val?Gly?Asn?Lys?Glu?Glu?Cys?Glu?Ile?Ala

195 200 205

Val?Gly?Glu?Thr?Glu?Pro?Glu?Arg?Ala?Gly?Arg?Ala?Leu?Leu?Glu?Arg

210 215 220

Gly?Val?Glu?Leu?Ala?Ile?Val?Lys?Gln?Gly?Pro?Lys?Gly?Val?Met?Ala

225 230 235 240

Met?Thr?Lys?Asp?Glu?Thr?Val?Glu?Val?Pro?Pro?Phe?Phe?Val?Asp?Val

245 250 255

Ile?Asn?Gly?Leu?Gly?Ala?Gly?Asp?Ala?Phe?Gly?Gly?Ala?Leu?Cys?His

260 265 270

Gly?Leu?Leu?Ser?Glu?Trp?Pro?Leu?Glu?Lys?Val?Leu?Arg?Phe?Ala?Asn

275 280 285

Thr?Ala?Gly?Ala?Leu?Val?Ala?Ser?Arg?Leu?Glu?Cys?Ser?Thr?Ala?Met

290 295 300

Pro?Thr?Thr?Asp?Glu?Val?Glu?Ala?Ser?Leu?Asn?Gln?Lys?Val

305 310 315

<210>329

<211>622

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(622)

<223>FRXA00872

<400>329

gaaatgtatt?gctttgtcag?gacaatgtgt?tattgtcatg?acatgcgatc?gtgagggtcg?60

ccacattcca?tcaaaaatga?gtgaagggtt?gcatcgccac?atg?act?aac?ttg?acg 115

Met?Thr?Asn?Leu?Thr

1 5

agc?act?cac?gaa?gtc?cta?gct?atc?ggc?cgc?ttg?ggc?gta?gat?att?tac 163

Ser?Thr?His?Glu?Val?Leu?Ala?Ile?Gly?Arg?Leu?Gly?Val?Asp?Ile?Tyr

10 15 20

cca?ctt?caa?agt?gga?gta?gga?ctg?gcc?gat?gtt?caa?tct?ttc?ggc?aag 211

Pro?Leu?Gln?Ser?Gly?Val?Gly?Leu?Ala?Asp?Val?Gln?Ser?Phe?Gly?Lys

25 30 35

tac?ctc?ggc?gga?agc?gca?gca?aac?gtt?tct?gtt?gca?gcc?gcc?cgc?cat 259

Tyr?Leu?Gly?Gly?Ser?Ala?Ala?Asn?Val?Ser?Val?Ala?Ala?Ala?Arg?His

40 45 50

gga?cac?aat?tcc?gca?ctg?ctg?tcc?cgt?gtg?gga?aat?gat?cct?ttc?ggc 307

Gly?His?Asn?Ser?Ala?Leu?Leu?Ser?Arg?Val?Gly?Asn?Asp?Pro?Phe?Gly

55 60 65

gag?tac?ctg?ctt?gct?gag?ctg?gag?cgt?ttg?ggc?gtg?gac?aac?cag?tac 355

Glu?Tyr?Leu?Leu?Ala?Glu?Leu?Glu?Arg?Leu?Gly?Val?Asp?Asn?Gln?Tyr

70 75 80 85

gtt?gcc?acc?gat?cag?act?ttt?aag?acc?cca?gtg?acc?ttc?tgt?gaa?att 403

Val?Ala?Thr?Asp?Gln?Thr?Phe?Lys?Thr?Pro?Val?Thr?Phe?Cys?Glu?Ile

90 95 100

ttc?cca?ccg?gat?gat?ttc?cca?ctg?tac?ttc?tac?cgc?gaa?cca?aag?gct 451

Phe?Pro?Pro?Asp?Asp?Phe?Pro?Leu?Tyr?Phe?Tyr?Arg?Glu?Pro?Lys?Ala

105 110 115

ccg?gat?ctc?aat?att?gaa?tcc?gca?gac?gtc?agc?ctg?gac?gat?gtg?cgc 499

Pro?Asp?Leu?Asn?Ile?Glu?Ser?Ala?Asp?Val?Ser?Leu?Asp?Asp?Val?Arg

120 125 130

gaa?gcc?gat?att?ttg?tgg?ttc?aca?ctc?act?ggt?ttc?agt?gaa?gag?cca 547

Glu?Ala?Asp?Ile?Leu?Trp?Phe?Thr?Leu?Thr?Gly?Phe?Ser?Glu?Glu?Pro

135 140 145

agc?cgc?ggc?aca?cac?cgc?gag?atc?ttg?act?act?cgt?gcg?aac?cgt?cgc 595

Ser?Arg?Gly?Thr?His?Arg?Glu?Ile?Leu?Thr?Thr?Arg?Ala?Asn?Arg?Arg

150 155 160 165

cac?acc?atc?ttt?gat?ctg?gac?tac?cga 622

His?Thr?Ile?Phe?Asp?Leu?Asp?Tyr?Arg

170

<210>330

<211>174

<212>PRT

＜213〉Corynebacterium glutamicum

<400>330

Met?Thr?Asn?Leu?Thr?Ser?Thr?His?Glu?Val?Leu?Ala?Ile?Gly?Arg?Leu

1 5 10 15

Gly?Val?Asp?Ile?Tyr?Pro?Leu?Gln?Ser?Gly?Val?Gly?Leu?Ala?Asp?Val

20 25 30

Gln?Ser?Phe?Gly?Lys?Tyr?Leu?Gly?Gly?Ser?Ala?Ala?Asn?Val?Ser?Val

35 40 45

Ala?Ala?Ala?Arg?His?Gly?His?Asn?Ser?Ala?Leu?Leu?Ser?Arg?Val?Gly

50 55 60

Asn?Asp?Pro?Phe?Gly?Glu?Tyr?Leu?Leu?Ala?Glu?Leu?Glu?Arg?Leu?Gly

65 70 75 80

Val?Asp?Asn?Gln?Tyr?Val?Ala?Thr?Asp?Gln?Thr?Phe?Lys?Thr?Pro?Val

85 90 95

Thr?Phe?Cys?Glu?Ile?Phe?Pro?Pro?Asp?Asp?Phe?Pro?Leu?Tyr?Phe?Tyr

100 105 110

Arg?Glu?Pro?Lys?Ala?Pro?Asp?Leu?Asn?Ile?Glu?Ser?Ala?Asp?Val?Ser

115 120 125

Leu?Asp?Asp?Val?Arg?Glu?Ala?Asp?Ile?Leu?Trp?Phe?Thr?Leu?Thr?Gly

130 135 140

Phe?Ser?Glu?Glu?Pro?Ser?Arg?Gly?Thr?His?Arg?Glu?Ile?Leu?Thr?Thr

145 150 155 160

Arg?Ala?Asn?Arg?Arg?His?Thr?Ile?Phe?Asp?Leu?Asp?Tyr?Arg

165 170

<210>331

<211>1767

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1744)

<223>RXN00799

<400>331

ttgtctaacc?ccgtataggt?gagaaatgtt?ggacaagtgt?ctgttttttg?tgggggaaat?60

ctgactacga?tggtaagaaa?taaggaaaga?gattaccatt?atg?tct?caa?gag?cgg 115

Met?Ser?Gln?Glu?Arg

1 5

cct?caa?atc?ggc?tcc?cgc?ctc?tct?cgt?gtc?att?gaa?caa?gac?ggc?cta 163

Pro?Gln?Ile?Gly?Ser?Arg?Leu?Ser?Arg?Val?Ile?Glu?Gln?Asp?Gly?Leu

10 15 20

caa?ttc?cgc?gat?ctc?gac?ggc?gac?ggc?gta?ctt?gca?cct?tat?gaa?gat 211

Gln?Phe?Arg?Asp?Leu?Asp?Gly?Asp?Gly?Val?Leu?Ala?Pro?Tyr?Glu?Asp

25 30 35

tgg?cgt?cta?acc?cca?gca?gag?cgt?gcc?gct?gac?ctg?gtg?aaa?cgt?atg 259

Trp?Arg?Leu?Thr?Pro?Ala?Glu?Arg?Ala?Ala?Asp?Leu?Val?Lys?Arg?Met

40 45 50

aat?gtg?gaa?gaa?aaa?gcg?ggc?ctg?atg?atc?atc?ggt?tcg?cac?tac?ccc 307

Asn?Val?Glu?Glu?Lys?Ala?Gly?Leu?Met?Ile?Ile?Gly?Ser?His?Tyr?Pro

55 60 65

gga?tac?tcg?cct?ttg?gcg?ccg?gag?agt?gaa?ggc?aaa?gac?gcg?gaa?aag 355

Gly?Tyr?Ser?Pro?Leu?Ala?Pro?Glu?Ser?Glu?Gly?Lys?Asp?Ala?Glu?Lys

70 75 80 85

tgc?gag?cct?ttg?ctg?aac?cct?gtc?gat?atg?tgg?cgt?gag?gat?aac?ccg 403

Cys?Glu?Pro?Leu?Leu?Asn?Pro?Val?Asp?Met?Trp?Arg?Glu?Asp?Asn?Pro

90 95 100

atc?acg?ggt?gtt?cct?ttc?acc?gag?cct?gtg?ctg?gca?act?tct?tcc?act 451

Ile?Thr?Gly?Val?Pro?Phe?Thr?Glu?Pro?Val?Leu?Ala?Thr?Ser?Ser?Thr

105 110 115

gaa?aat?gcc?att?aac?ctg?cgc?aat?cag?cgt?tac?tta?att?gtt?cgt?gac 499

Glu?Asn?Ala?Ile?Asn?Leu?Arg?Asn?Gln?Arg?Tyr?Leu?Ile?Val?Arg?Asp

120 125 130

aac?ctg?cca?gct?cgt?ggg?ctt?gct?act?tgg?acc?aat?gct?gtt?cag?gaa 547

Asn?Leu?Pro?Ala?Arg?Gly?Leu?Ala?Thr?Trp?Thr?Asn?Ala?Val?Gln?Glu

135 140 145

gtc?gcg?gag?cga?tcc?cgt?ttg?ggt?att?cct?gtt?gcg?ttt?gcg?tcg?aat 595

Val?Ala?Glu?Arg?Ser?Arg?Leu?Gly?Ile?Pro?Val?Ala?Phe?Ala?Ser?Asn

150 155 160 165

cct?cgt?aac?cac?gtc?gcg?ctc?gtt?gcg?cag?ttc?ggt?gtg?aac?gag?tcc 643

Pro?Arg?Asn?His?Val?Ala?Leu?Val?Ala?Gln?Phe?Gly?Val?Asn?Glu?Ser

170 175 180

gcg?ggt?gtg?ttc?tct?gag?tgg?cct?ggc?gag?ctg?ggt?ctt?gct?gcg?ctt 691

Ala?Gly?Val?Phe?Ser?Glu?Trp?Pro?Gly?Glu?Leu?Gly?Leu?Ala?Ala?Leu

185 190 195

cgc?gat?gct?gaa?ctg?atg?gag?act?ttc?ggt?acc?gag?gct?gct?aaa?gaa 739

Arg?Asp?Ala?Glu?Leu?Met?Glu?Thr?Phe?Gly?Thr?Glu?Ala?Ala?Lys?Glu

200 205 210

tgg?cgt?gcc?ggt?ggt?gtg?cac?aag?ctg?tac?ggt?tac?atg?gct?gac?ctc 787

Trp?Arg?Ala?Gly?Gly?Val?His?Lys?Leu?Tyr?Gly?Tyr?Met?Ala?Asp?Leu

215 220 225

gct?tct?gag?cct?cgt?tgg?tcc?cgc?ttc?aac?ggt?act?ttt?ggt?gag?gat 835

Ala?Ser?Glu?Pro?Arg?Trp?Ser?Arg?Phe?Asn?Gly?Thr?Phe?Gly?Glu?Asp

230 235 240 245

ccg?gag?ttg?atc?tct?gat?tac?atc?gct?gct?gtt?gtg?cgt?ggt?ttg?cag 883

Pro?Glu?Leu?Ile?Ser?Asp?Tyr?Ile?Ala?Ala?Val?Val?Arg?Gly?Leu?Gln

250 255 260

ggc?cct?gag?ctg?tcc?aag?aat?tcc?gtg?tcg?acc?acc?att?aag?cac?ttc 931

Gly?Pro?Glu?Leu?Ser?Lys?Asn?Ser?Val?Ser?Thr?Thr?Ile?Lys?His?Phe

265 270 275

cca?ggt?ggc?ggc?gtg?cgc?ctc?gac?ggc?cac?gat?cct?cac?ttc?cac?tgg 979

Pro?Gly?Gly?Gly?Val?Arg?Leu?Asp?Gly?His?Asp?Pro?His?Phe?His?Trp

280 285 290

ggt?cag?acc?aat?gag?tac?cca?acc?gaa?gat?gcg?ctg?ggc?aag?tac?cat 1027

Gly?Gln?Thr?Asn?Glu?Tyr?Pro?Thr?Glu?Asp?Ala?Leu?Gly?Lys?Tyr?His

295 300 305

ctg?cct?cct?ttc?cag?gca?gct?atc?gac?gct?ggc?tgc?gcc?tcg?atc?atg 1075

Leu?Pro?Pro?Phe?Gln?Ala?Ala?Ile?Asp?Ala?Gly?Cys?Ala?Ser?Ile?Met

310 315 320 325

cct?tac?tac?gca?cgg?cca?atg?aac?aac?tcc?gcc?aac?cag?ctc?gat?cag 1123

Pro?Tyr?Tyr?Ala?Arg?Pro?Met?Asn?Asn?Ser?Ala?Asn?Gln?Leu?Asp?Gln

330 335 340

cag?ctg?tgg?caa?aac?ccg?acc?acg?cag?ttc?gaa?gag?gtt?gcg?ttt?gcc 1171

Gln?Leu?Trp?Gln?Asn?Pro?Thr?Thr?Gln?Phe?Glu?Glu?Val?Ala?Phe?Ala

345 350 355

tac?aac?cgc?acc?ttc?att?cag?gat?ttg?ctt?cgc?gac?gcc?atg?ggc?cac 1219

Tyr?Asn?Arg?Thr?Phe?Ile?Gln?Asp?Leu?Leu?Arg?Asp?Ala?Met?Gly?His

360 365 370

cgt?ggg?tac?gtc?aac?tcc?gac?tcc?ggc?gtc?atc?gac?gcc?atg?atg?tgg 1267

Arg?Gly?Tyr?Val?Asn?Ser?Asp?Ser?Gly?Val?Ile?Asp?Ala?Met?Met?Trp

375 380 385

ggc?gtg?gag?gaa?ctc?agc?gag?cca?gaa?cgc?ttc?gcc?gca?gca?gtg?cgt 1315

Gly?Val?Glu?Glu?Leu?Ser?Glu?Pro?Glu?Arg?Phe?Ala?Ala?Ala?Val?Arg

390 395 400 405

gca?ggc?acc?gac?att?ttc?tcc?gac?atg?gct?aac?cca?cgt?cga?ctg?ctc 1363

Ala?Gly?Thr?Asp?Ile?Phe?Ser?Asp?Met?Ala?Asn?Pro?Arg?Arg?Leu?Leu

410 415 420

gaa?gca?gtt?gct?gag?gga?cac?ctt?gat?gag?tca?gag?ctg?aat?cag?cca 1411

Glu?Ala?Val?Ala?Glu?Gly?His?Leu?Asp?Glu?Ser?Glu?Leu?Asn?Gln?Pro

425 430 435

gtc?cag?cga?ctc?ctg?gag?gaa?atc?ttc?cag?ctt?ggt?ctg?ttt?gag?aac 1459

Val?Gln?Arg?Leu?Leu?Glu?Glu?Ile?Phe?Gln?Leu?Gly?Leu?Phe?Glu?Asn

440 445 450

cca?tat?gtc?tct?gaa?gat?gaa?gca?gaa?aag?atc?att?ggt?gcg?cca?gag 1507

Pro?Tyr?Val?Ser?Glu?Asp?Glu?Ala?Glu?Lys?Ile?Ile?Gly?Ala?Pro?Glu

455 460 465

gtt?tct?gca?ttg?ggc?aac?aaa?gca?cag?ctt?gat?tcc?gtc?acc?ttg?ctg 1555

Val?Ser?Ala?Leu?Gly?Asn?Lys?Ala?Gln?Leu?Asp?Ser?Val?Thr?Leu?Leu

470 475 480 485

cgt?aac?aac?ccc?atc?cgt?gct?gcc?act?gga?tcc?tgc?agc?aag?cct?gaa 1603

Arg?Asn?Asn?Pro?Ile?Arg?Ala?Ala?Thr?Gly?Ser?Cys?Ser?Lys?Pro?Glu

490 495 500

gat?cta?ccc?att?ggt?tac?tgg?ccg?tac?caa?gat?cga?cga?ggt?tca?act 1651

Asp?Leu?Pro?Ile?Gly?Tyr?Trp?Pro?Tyr?Gln?Asp?Arg?Arg?Gly?Ser?Thr

505 510 515

aca?gct?gga?agc?agc?cat?tcg?cgc?aga?act?ccc?agg?ggt?aac?ctt?ggt 1699

Thr?Ala?Gly?Ser?Ser?His?Ser?Arg?Arg?Thr?Pro?Arg?Gly?Asn?Leu?Gly

520 525 530

gtc?ttc?cga?gtc?aga?agc?aga?tct?tgc?aat?cgt?gtg?ggc?tcg?ccc 1744

Val?Phe?Arg?Val?Arg?Ser?Arg?Ser?Cys?Asn?Arg?Val?Gly?Ser?Pro

535 540 545

tgaaattgca?ctgtttgaag?atg 1767

<210>332

<211>548

<212>PRT

＜213〉Corynebacterium glutamicum

<400>332

Met?Ser?Gln?Glu?Arg?Pro?Gln?Ile?Gly?Ser?Arg?Leu?Ser?Arg?Val?Ile

1 5 10 15

Glu?Gln?Asp?Gly?Leu?Gln?Phe?Arg?Asp?Leu?Asp?Gly?Asp?Gly?Val?Leu

20 25 30

Ala?Pro?Tyr?Glu?Asp?Trp?Arg?Leu?Thr?Pro?Ala?Glu?Arg?Ala?Ala?Asp

35 40 45

Leu?Val?Lys?Arg?Met?Asn?Val?Glu?Glu?Lys?Ala?Gly?Leu?Met?Ile?Ile

50 55 60

Gly?Ser?His?Tyr?Pro?Gly?Tyr?Ser?Pro?Leu?Ala?Pro?Glu?Ser?Glu?Gly

65 70 75 80

Lys?Asp?Ala?Glu?Lys?Cys?Glu?Pro?Leu?Leu?Asn?Pro?Val?Asp?Met?Trp

85 90 95

Arg?Glu?Asp?Asn?Pro?Ile?Thr?Gly?Val?Pro?Phe?Thr?Glu?Pro?Val?Leu

100 105 110

Ala?Thr?Ser?Ser?Thr?Glu?Asn?Ala?Ile?Asn?Leu?Arg?Asn?Gln?Arg?Tyr

115 120 125

Leu?Ile?Val?Arg?Asp?Asn?Leu?Pro?Ala?Arg?Gly?Leu?Ala?Thr?Trp?Thr

130 135 140

Asn?Ala?Val?Gln?Glu?Val?Ala?Glu?Arg?Ser?Arg?Leu?Gly?Ile?Pro?Val

145 150 155 160

Ala?Phe?Ala?Ser?Asn?Pro?Arg?Asn?His?Val?Ala?Leu?Val?Ala?Gln?Phe

165 170 175

Gly?Val?Asn?Glu?Ser?Ala?Gly?Val?Phe?Ser?Glu?Trp?Pro?Gly?Glu?Leu

180 185 190

Gly?Leu?Ala?Ala?Leu?Arg?Asp?Ala?Glu?Leu?Met?Glu?Thr?Phe?Gly?Thr

195 200 205

Glu?Ala?Ala?Lys?Glu?Trp?Arg?Ala?Gly?Gly?Val?His?Lys?Leu?Tyr?Gly

210 215 220

Tyr?Met?Ala?Asp?Leu?Ala?Ser?Glu?Pro?Arg?Trp?Ser?Arg?Phe?Asn?Gly

225 230 235 240

Thr?Phe?Gly?Glu?Asp?Pro?Glu?Leu?Ile?Ser?Asp?Tyr?Ile?Ala?Ala?Val

245 250 255

Val?Arg?Gly?Leu?Gln?Gly?Pro?Glu?Leu?Ser?Lys?Asn?Ser?Val?Ser?Thr

260 265 270

Thr?Ile?Lys?His?Phe?Pro?Gly?Gly?Gly?Val?Arg?Leu?Asp?Gly?His?Asp

275 280 285

Pro?His?Phe?His?Trp?Gly?Gln?Thr?Asn?Glu?Tyr?Pro?Thr?Glu?Asp?Ala

290 295 300

Leu?Gly?Lys?Tyr?His?Leu?Pro?Pro?Phe?Gln?Ala?Ala?Ile?Asp?Ala?Gly

305 310 315 320

Cys?Ala?Ser?Ile?Met?Pro?Tyr?Tyr?Ala?Arg?Pro?Met?Asn?Asn?Ser?Ala

325 330 335

Asn?Gln?Leu?Asp?Gln?Gln?Leu?Trp?Gln?Asn?Pro?Thr?Thr?Gln?Phe?Glu

340 345 350

Glu?Val?Ala?Phe?Ala?Tyr?Asn?Arg?Thr?Phe?Ile?Gln?Asp?Leu?Leu?Arg

355 360 365

Asp?Ala?Met?Gly?His?Arg?Gly?Tyr?Val?Asn?Ser?Asp?Ser?Gly?Val?Ile

370 375 380

Asp?Ala?Met?Met?Trp?Gly?Val?Glu?Glu?Leu?Ser?Glu?Pro?Glu?Arg?Phe

385 390 395 400

Ala?Ala?Ala?Val?Arg?Ala?Gly?Thr?Asp?Ile?Phe?Ser?Asp?Met?Ala?Asn

405 410 415

Pro?Arg?Arg?Leu?Leu?Glu?Ala?Val?Ala?Glu?Gly?His?Leu?Asp?Glu?Ser

420 425 430

Glu?Leu?Asn?Gln?Pro?Val?Gln?Arg?Leu?Leu?Glu?Glu?Ile?Phe?Gln?Leu

435 440 445

Gly?Leu?Phe?Glu?Asn?Pro?Tyr?Val?Ser?Glu?Asp?Glu?Ala?Glu?Lys?Ile

450 455 460

Ile?Gly?Ala?Pro?Glu?Val?Ser?Ala?Leu?Gly?Asn?Lys?Ala?Gln?Leu?Asp

465 470 475 480

Ser?Val?Thr?Leu?Leu?Arg?Asn?Asn?Pro?Ile?Arg?Ala?Ala?Thr?Gly?Ser

485 490 495

Cys?Ser?Lys?Pro?Glu?Asp?Leu?Pro?Ile?Gly?Tyr?Trp?Pro?Tyr?Gln?Asp

500 505 510

Arg?Arg?Gly?Ser?Thr?Thr?Ala?Gly?Ser?Ser?His?Ser?Arg?Arg?Thr?Pro

515 520 525

Arg?Gly?Asn?Leu?Gly?Val?Phe?Arg?Val?Arg?Ser?Arg?Ser?Cys?Asn?Arg

530 535 540

Val?Gly?Ser?Pro

545

<210>333

<211>1607

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(1584)

<223>FRXA00799

<400>333

cta?caa?ttc?cgc?gat?ctc?gac?ggc?gac?ggc?gta?ctt?gca?cct?tat?gaa 48

Leu?Gln?Phe?Arg?Asp?Leu?Asp?Gly?Asp?Gly?Val?Leu?Ala?Pro?Tyr?Glu

1 5 10 15

gat?tgg?cgt?cta?acc?cca?gca?gag?cgt?gcc?gct?gac?ctg?gtg?aaa?cgt 96

Asp?Trp?Arg?Leu?Thr?Pro?Ala?Glu?Arg?Ala?Ala?Asp?Leu?Val?Lys?Arg

20 25 30

atg?aat?gtg?gaa?gaa?aaa?gcg?ggc?ctg?atg?atc?atc?ggt?tcg?cac?tac 144

Met?Asn?Val?Glu?Glu?Lys?Ala?Gly?Leu?Met?Ile?Ile?Gly?Ser?His?Tyr

35 40 45

ccc?gga?tac?tcg?cct?ttg?gcg?ccg?gag?agt?gaa?ggc?aaa?gac?gcg?gaa 192

Pro?Gly?Tyr?Ser?Pro?Leu?Ala?Pro?Glu?Ser?Glu?Gly?Lys?Asp?Ala?Glu

50 55 60

aag?tgc?gag?cct?ttg?ctg?aac?cct?gtc?gat?atg?tgg?cgt?gag?gat?aac 240

Lys?Cys?Glu?Pro?Leu?Leu?Asn?Pro?Val?Asp?Met?Trp?Arg?Glu?Asp?Asn

65 70 75 80

ccg?atc?acg?ggt?gtt?cct?ttc?acc?gag?cct?gtg?ctg?gca?act?tct?tcc 288

Pro?Ile?Thr?Gly?Val?Pro?Phe?Thr?Glu?Pro?Val?Leu?Ala?Thr?Ser?Ser

85 90 95

act?gaa?aat?gcc?att?aac?ctg?cgc?aat?cag?cgt?tac?tta?att?gtt?cgt 336

Thr?Glu?Asn?Ala?Ile?Asn?Leu?Arg?Asn?Gln?Arg?Tyr?Leu?Ile?Val?Arg

100 105 110

gac?aac?ctg?cca?gct?cgt?ggg?ctt?gct?act?tgg?acc?aat?gct?gtt?cag 384

Asp?Asn?Leu?Pro?Ala?Arg?Gly?Leu?Ala?Thr?Trp?Thr?Asn?Ala?Val?Gln

115 120 125

gaa?gtc?gcg?gag?cga?tcc?cgt?ttg?ggt?att?cct?gtt?gcg?ttt?gcg?tcg 432

Glu?Val?Ala?Glu?Arg?Ser?Arg?Leu?Gly?Ile?Pro?Val?Ala?Phe?Ala?Ser

130 135 140

aat?cct?cgt?aac?cac?gtc?gcg?ctc?gtt?gcg?cag?ttc?ggt?gtg?aac?gag 480

Asn?Pro?Arg?Asn?His?Val?Ala?Leu?Val?Ala?Gln?Phe?Gly?Val?Asn?Glu

145 150 155 160

tcc?gcg?ggt?gtg?ttc?tct?gag?tgg?cct?ggc?gag?ctg?ggt?ctt?gct?gcg 528

Ser?Ala?Gly?Val?Phe?Ser?Glu?Trp?Pro?Gly?Glu?Leu?Gly?Leu?Ala?Ala

165 170 175

ctt?cgc?gat?gct?gaa?ctg?atg?gag?act?ttc?ggt?acc?gag?gct?gct?aaa 576

Leu?Arg?Asp?Ala?Glu?Leu?Met?Glu?Thr?Phe?Gly?Thr?Glu?Ala?Ala?Lys

180 185 190

gaa?tgg?cgt?gcc?ggt?ggt?gtg?cac?aag?ctg?tac?ggt?tac?atg?gct?gac 624

Glu?Trp?Arg?Ala?Gly?Gly?Val?His?Lys?Leu?Tyr?Gly?Tyr?Met?Ala?Asp

195 200 205

ctc?gct?tct?gag?cct?cgt?tgg?tcc?cgc?ttc?aac?ggt?act?ttt?ggt?gag 672

Leu?Ala?Ser?Glu?Pro?Arg?Trp?Ser?Arg?Phe?Asn?Gly?Thr?Phe?Gly?Glu

210 215 220

gat?ccg?gag?ttg?atc?tct?gat?tac?atc?gct?gct?gtt?gtg?cgt?ggt?ttg 720

Asp?Pro?Glu?Leu?Ile?Ser?Asp?Tyr?Ile?Ala?Ala?Val?Val?Arg?Gly?Leu

225 230 235 240

cag?ggc?cct?gag?ctg?tcc?aag?aat?tcc?gtg?tcg?acc?acc?att?aag?cac 768

Gln?Gly?Pro?Glu?Leu?Ser?Lys?Asn?Ser?Val?Ser?Thr?Thr?Ile?Lys?His

245 250 255

ttc?cca?ggt?ggc?ggc?gtg?cgc?ctc?gac?ggc?cac?gat?cct?cac?ttc?cac 816

Phe?Pro?Gly?Gly?Gly?Val?Arg?Leu?Asp?Gly?His?Asp?Pro?His?Phe?His

260 265 270

tgg?ggt?cag?acc?aat?gag?tac?cca?acc?gaa?gat?gcg?ctg?ggc?aag?tac 864

Trp?Gly?Gln?Thr?Asn?Glu?Tyr?Pro?Thr?Glu?Asp?Ala?Leu?Gly?Lys?Tyr

275 280 285

cat?ctg?cct?cct?ttc?cag?gca?get?ate?gac?get?ggc?tgc?gcc?tcg?atc 912

His?Leu?Pro?Pro?Phe?Gln?Ala?Ala?Ile?Asp?Ala?Gly?Cys?Ala?Ser?Ile

290 295 300

atg?cct?tac?tac?gca?cgg?cca?atg?aac?aac?tcc?gcc?aac?cag?ctc?gat 960

Met?Pro?Tyr?Tyr?Ala?Arg?Pro?Met?Asn?Asn?Ser?Ala?Asn?Gln?Leu?Asp

305 310 315 320

cag?cag?ctg?tgg?caa?aac?ccg?acc?acg?cag?ttc?gaa?gag?gtt?gcg?ttt 1008

Gln?Gln?Leu?Trp?Gln?Asn?Pro?Thr?Thr?Gln?Phe?Glu?Glu?Val?Ala?Phe

325 330 335

gcc?tac?aac?cgc?acc?ttc?att?cag?gat?ttg?ctt?cgc?gac?gcc?atg?ggc 1056

Ala?Tyr?Asn?Arg?Thr?Phe?Ile?Gln?Asp?Leu?Leu?Arg?Asp?Ala?Met?Gly

340 345 350

cac?cgt?ggg?tac?gtc?aac?tcc?gac?tcc?ggc?gtc?atc?gac?gcc?atg?atg 1104

His?Arg?Gly?Tyr?Val?Asn?Ser?Asp?Ser?Gly?Val?Ile?Asp?Ala?Met?Met

355 360 365

tgg?ggc?gtg?gag?gaa?ctc?agc?gag?cca?gaa?cgc?ttc?gcc?gca?gca?gtg 1152

Trp?Gly?Val?Glu?Glu?Leu?Ser?Glu?Pro?Glu?Arg?Phe?Ala?Ala?Ala?Val

370 375 380

cgt?gca?ggc?acc?gac?att?ttc?tcc?gac?atg?gct?aac?cca?cgt?cga?ctg 1200

Arg?Ala?Gly?Thr?Asp?Ile?Phe?Ser?Asp?Met?Ala?Asn?Pro?Arg?Arg?Leu

385 390 395 400

ctc?gaa?gca?gtt?gct?gag?gga?cac?ctt?gat?gag?tca?gag?ctg?aat?cag 1248

Leu?Glu?Ala?Val?Ala?Glu?Gly?His?Leu?Asp?Glu?Ser?Glu?Leu?Asn?Gln

405 410 415

cca?gtc?cag?cga?ctc?ctg?gag?gaa?atc?ttc?cag?ctt?ggt?ctg?ttt?gag 1296

Pro?Val?Gln?Arg?Leu?Leu?Glu?Glu?Ile?Phe?Gln?Leu?Gly?Leu?Phe?Glu

420 425 430

aac?cca?tat?gtc?tct?gaa?gat?gaa?gca?gaa?aag?atc?att?ggt?gcg?cca 1344

Asn?Pro?Tyr?Val?Ser?Glu?Asp?Glu?Ala?Glu?Lys?Ile?Ile?Gly?Ala?Pro

435 440 445

gag?gtt?tct?gca?ttg?ggc?aac?aaa?gca?cag?ctt?gat?tcc?gtc?acc?ttg 1392

Glu?Val?Ser?Ala?Leu?Gly?Asn?Lys?Ala?Gln?Leu?Asp?Ser?Val?Thr?Leu

450 455 460

ctg?cgt?aac?aac?ccc?atc?cgt?gct?gcc?act?gga?tcc?tgc?agc?aag?cct 1440

Leu?Arg?Asn?Asn?Pro?Ile?Arg?Ala?Ala?Thr?Gly?Ser?Cys?Ser?Lys?Pro

465 470 475 480

gaa?gat?cta?ccc?att?ggt?tac?tgg?ccg?tac?caa?gat?cga?cga?ggt?tca 1488

Glu?Asp?Leu?Pro?Ile?Gly?Tyr?trp?Pro?Tyr?Gln?Asp?Arg?Arg?Gly?Ser

485 490 495

act?aca?gct?gga?agc?agc?cat?tcg?cgc?aga?act?ccc?agg?ggt?aac?ctt 1536

Thr?Thr?Ala?Gly?Ser?Ser?His?Ser?Arg?Arg?Thr?Pro?Arg?Gly?Asn?Leu

500 505 510

ggt?gtc?ttc?cga?gtc?aga?agc?aga?tct?tgc?aat?cgt?gtg?ggc?tcg?ccc 1584

Gly?Val?Phe?Arg?Val?Arg?Ser?Arg?Ser?Cys?Asn?Arg?Val?Gly?Ser?Pro

515 520 525

tgaaattgca?ctgtttgaag?atg 1607

<210>334

<211>528

<212>PRT

＜213〉Corynebacterium glutamicum

<400>334

Leu?Gln?Phe?Arg?Asp?Leu?Asp?Gly?Asp?Gly?Val?Leu?Ala?Pro?Tyr?Glu

1 5 10 15

Asp?Trp?Arg?Leu?Thr?Pro?Ala?Glu?Arg?Ala?Ala?Asp?Leu?Val?Lys?Arg

20 25 30

Met?Asn?Val?Glu?Glu?Lys?Ala?Gly?Leu?Met?Ile?Ile?Gly?Ser?His?Tyr

35 40 45

Pro?Gly?Tyr?Ser?Pro?Leu?Ala?Pro?Glu?Ser?Glu?Gly?Lys?Asp?Ala?Glu

50 55 60

Lys?Cys?Glu?Pro?Leu?Leu?Asn?Pro?Val?Asp?Met?Trp?Arg?Glu?Asp?Asn

65 70 75 80

Pro?Ile?Thr?Gly?Val?Pro?Phe?Thr?Glu?Pro?Val?Leu?Ala?Thr?Ser?Ser

85 90 95

Thr?Glu?Asn?Ala?Ile?Asn?Leu?Arg?Asn?Gln?Arg?Tyr?Leu?Ile?Val?Arg

100 105 110

Asp?Asn?Leu?Pro?Ala?Arg?Gly?Leu?Ala?Thr?Trp?Thr?Asn?Ala?Val?Gln

115 120 125

Glu?Val?Ala?Glu?Arg?Ser?Arg?Leu?Gly?Ile?Pro?Val?Ala?Phe?Ala?Ser

130 135 140

Asn?Pro?Arg?Asn?His?Val?Ala?Leu?Val?Ala?Gln?Phe?Gly?Val?Asn?Glu

145 150 155 160

Ser?Ala?Gly?Val?Phe?Ser?Glu?Trp?Pro?Gly?Glu?Leu?Gly?Leu?Ala?Ala

165 170 175

Leu?Arg?Asp?Ala?Glu?Leu?Met?Glu?Thr?Phe?Gly?Thr?Glu?Ala?Ala?Lys

180 185 190

Glu?Trp?Arg?Ala?Gly?Gly?Val?His?Lys?Leu?Tyr?Gly?Tyr?Met?Ala?Asp

195 200 205

Leu?Ala?Ser?Glu?Pro?Arg?Trp?Ser?Arg?Phe?Asn?Gly?Thr?Phe?Gly?Glu

210 215 220

Asp?Pro?Glu?Leu?Ile?Ser?Asp?Tyr?Ile?Ala?Ala?Val?Val?Arg?Gly?Leu

225 230 235 240

Gln?Gly?Pro?Glu?Leu?Ser?Lys?Asn?Ser?Val?Ser?Thr?Thr?Ile?Lys?His

245 250 255

Phe?Pro?Gly?Gly?Gly?Val?Arg?Leu?Asp?Gly?His?Asp?Pro?His?Phe?His

260 265 270

Trp?Gly?Gln?Thr?Asn?Glu?Tyr?Pro?Thr?Glu?Asp?Ala?Leu?Gly?Lys?Tyr

275 280 285

His?Leu?Pro?Pro?Phe?Gln?Ala?Ala?Ile?Asp?Ala?Gly?Cys?Ala?Ser?Ile

290 295 300

Met?Pro?Tyr?Tyr?Ala?Arg?Pro?Met?Asn?Asn?Ser?Ala?Asn?Gln?Leu?Asp

305 310 315 320

Gln?Gln?Leu?Trp?Gln?Asn?Pro?Thr?Thr?Gln?Phe?Glu?Glu?Val?Ala?Phe

325 330 335

Ala?Tyr?Asn?Arg?Thr?Phe?Ile?Gln?Asp?Leu?Leu?Arg?Asp?Ala?Met?Gly

340 345 350

His?Arg?Gly?Tyr?Val?Asn?Ser?Asp?Ser?Gly?Val?Ile?Asp?Ala?Met?Met

355 360 365

Trp?Gly?Val?Glu?Glu?Leu?Ser?Glu?Pro?Glu?Arg?Phe?Ala?Ala?Ala?Val

370 375 380

Arg?Ala?Gly?Thr?Asp?Ile?Phe?Ser?Asp?Met?Ala?Asn?Pro?Arg?Arg?Leu

385 390 395 400

Leu?Glu?Ala?Val?Ala?Glu?Gly?His?Leu?Asp?Glu?Ser?Glu?Leu?Asn?Gln

405 410 415

Pro?Val?Gln?Arg?Leu?Leu?Glu?Glu?Ile?Phe?Gln?Leu?Gly?Leu?Phe?Glu

420 425 430

Asn?Pro?Tyr?Val?Ser?Glu?Asp?Glu?Ala?Glu?Lys?Ile?Ile?Gly?Ala?Pro

435 440 445

Glu?Val?Ser?Ala?Leu?Gly?Asn?Lys?Ala?Gln?Leu?Asp?Ser?Val?Thr?Leu

450 455 460

Leu?Arg?Asn?Asn?Pro?Ile?Arg?Ala?Ala?Thr?Gly?Ser?Cys?Ser?Lys?Pro

465 470 475 480

Glu?Asp?Leu?Pro?Ile?Gly?Tyr?Trp?Pro?Tyr?Gln?Asp?Arg?Arg?Gly?Ser

485 490 495

Thr?Thr?Ala?Gly?Ser?Ser?His?Ser?Arg?Arg?Thr?Pro?Arg?Gly?Asn?Leu

500 505 510

Gly?Val?Phe?Arg?Val?Arg?Ser?Arg?Ser?Cys?Asn?Arg?Val?Gly?Ser?Pro

515 520 525

<210>335

<211>1632

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1609)

<223>RXA00032

<400>335

cacttgctga?agacgcccac?atcgaagacc?ttgcagatgt?aaacgcaaac?gcctaactgt?60

ttttcgagct?aaacccatcc?ttgaaaggat?cttttccacc?atg?aac?acc?cca?ctc 115

Met?Asn?Thr?Pro?Leu

1 5

cag?ctc?aac?act?gaa?aac?ctg?cag?gaa?atc?gct?tcg?act?tcc?gga?gtg 163

Gln?Leu?Asn?Thr?Glu?Asn?Leu?Gln?Glu?lle?Ala?Ser?Thr?Ser?Gly?Val

10 15 20

cag?atc?cca?gcg?ttc?aac?cgc?gct?gac?gtc?gcc?ccg?ggc?att?gtc?cac 211

Gln?Ile?Pro?Ala?Phe?Asn?Arg?Ala?Asp?Val?Ala?Pro?Gly?Ile?Val?His

25 30 35

ttc?ggt?gtt?ggc?gga?ttc?cat?cgc?gct?cac?caa?gcg?atg?tac?ctc?aat 259

Phe?Gly?Val?Gly?Gly?Phe?His?Arg?Ala?His?Gln?Ala?Met?Tyr?Leu?Asn

40 45 50

gaa?ttg?atg?aat?gag?ggc?aag?gcc?ttg?gat?tgg?ggc?atc?atc?ggc?atg 307

Glu?Leu?Met?Asn?Glu?Gly?Lys?Ala?Leu?Asp?Trp?Gly?Ile?Ile?Gly?Met

55 60 65

ggt?gtc?atg?cct?tcc?gat?gtg?cgc?atg?cgc?gat?gcc?ctg?gcc?agc?caa 355

Gly?Val?Met?Pro?Ser?Asp?Val?Arg?Met?Arg?Asp?Ala?Leu?Ala?Ser?Gln

70 75 80 85

gat?cac?ctt?tat?acc?ctg?acc?act?aaa?gct?cct?gat?gga?act?ctt?gat 403

Asp?His?Leu?Tyr?Thr?Leu?Thr?Thr?Lys?Ala?Pro?Asp?Gly?Thr?Leu?Asp

90 95 100

caa?aaa?atc?atc?gga?tcc?atc?att?gac?tac?gtg?ttc?gct?ccc?gag?gac 451

Gln?Lys?Ile?Ile?Gly?Ser?Ile?Ile?Asp?Tyr?Val?Phe?Ala?Pro?Glu?Asp

105 110 115

cca?gca?cgg?gcc?gtt?gca?acc?ctc?gcg?cag?gac?tcc?atc?cgc?att?gtt 499

Pro?Ala?Arg?Ala?Val?Ala?Thr?Leu?Ala?Gln?Asp?Ser?Ile?Arg?Ile?Val

120 125 130

tcc?ctc?acg?gtg?act?gaa?ggc?gga?tac?aac?atc?gat?ccg?gcg?aca?gaa 547

Ser?Leu?Thr?Val?Thr?Glu?Gly?Gly?Tyr?Asn?Ile?Asp?Pro?Ala?Thr?Glu

135 140 145

gat?ttc?gac?cac?acc?aac?cct?cga?atc?gtt?gct?gac?cgc?gaa?gcc?ctg 595

Asp?Phe?Asp?His?Thr?Asn?Pro?Arg?Ile?Val?Ala?Asp?Arg?Glu?Ala?Leu

150 155 160 165

cag?gcg?ggc?gat?act?tcc?act?ttg?cag?acc?ttc?ttt?ggg?ttg?atc?act 643

Gln?Ala?Gly?Asp?Thr?Ser?Thr?Leu?Gln?Thr?Phe?Phe?Gly?Leu?Ile?Thr

170 175 180

gcc?gca?ttg?att?tcc?cga?aaa?gaa?tca?gga?tct?acg?cca?ttt?acc?atc 691

Ala?Ala?Leu?Ile?Ser?Arg?Lys?Glu?Ser?Gly?Ser?Thr?Pro?Phe?Thr?Ile

185 190 195

atg?agc?tgc?gat?aac?atc?caa?ggc?aac?ggc?gat?ctg?gct?aag?cgt?ttc 739

Met?Ser?Cys?Asp?Asn?Ile?Gln?Gly?Asn?Gly?Asp?Leu?Ala?Lys?Arg?Phe

200 205 210

ttc?ctc?gcc?ttc?gca?cat?tcc?gtg?tct?tct?gag?ctc?ggc?gaa?tgg?gtg 787

Phe?Leu?Ala?Phe?Ala?His?Ser?Val?Ser?Ser?Glu?Leu?Gly?Glu?Trp?Val

215 220 225

gaa?aac?aac?gtg?gcc?ttc?ccc?aac?tcc?atg?gtg?gac?cgc?atc?acc?cct 835

Glu?Asn?Asn?Val?Ala?Phe?Pro?Asn?Ser?Met?Val?Asp?Arg?Ile?Thr?Pro

230 235 240 245

gaa?acc?acc?gac?ggc?gac?cgc?gat?gac?atc?aag?gaa?atc?ggc?tac?atc 883

Glu?Thr?Thr?Asp?Gly?Asp?Arg?Asp?Asp?Ile?Lys?Glu?Ile?Gly?Tyr?Ile

250 255 260

gat?gcg?tgg?cca?gtg?gtt?tct?gaa?gat?ttc?acc?caa?tgg?gtc?ctc?gag 931

Asp?Ala?Trp?Pro?Val?Val?Ser?Glu?Asp?Phe?Thr?Gln?Trp?Val?Leu?Glu

265 270 275

gat?gcc?ttc?acc?cag?ggc?cgc?ccc?gcg?tac?gag?gag?gtt?ggc?gtg?cag 979

Asp?Ala?Phe?Thr?Gln?Gly?Arg?Pro?Ala?Tyr?Glu?Glu?Val?Gly?Val?Gln

280 285 290

gtc?gtc?tcc?gac?gtg?gag?cct?tat?gaa?tta?atg?aag?ctg?cgc?ctg?ctc 1027

Val?Val?Ser?Asp?Val?Glu?Pro?Tyr?Glu?Leu?Met?Lys?Leu?Arg?Leu?Leu

295 300 305

aac?gcc?tcc?cac?cag?gga?ctt?tgc?tac?ttc?ggc?cac?ttg?gct?ggc?cac 1075

Asn?Ala?Ser?His?Gln?Gly?Leu?Cys?Tyr?Phe?Gly?His?Leu?Ala?Gly?His

310 315 320 325

cac?atg?gtc?cac?gac?gtc?atg?gcg?gat?acc?cgc?ttc?cag?gat?ttc?ctc 1123

His?Met?Val?His?Asp?Val?Met?Ala?Asp?Thr?Arg?Phe?Gln?Asp?Phe?Leu

330 335 340

ctg?gct?tac?atg?gag?cgc?gaa?gcc?acc?cct?acc?ctc?aag?gaa?ctt?cca 1171

Leu?Ala?Tyr?Met?Glu?Arg?Glu?Ala?Thr?Pro?Thr?Leu?Lys?Glu?Leu?Pro

345 350 355

ggt?gtc?gat?cta?gat?gct?tat?cga?cgc?caa?ctc?atc?gcg?cga?ttc?ggc 1219

Gly?Val?Asp?Leu?Asp?Ala?Tyr?Arg?Arg?Gln?Leu?Ile?Ala?Arg?Phe?Gly

360 365 370

aac?gcc?gca?gtc?aaa?gac?acc?gta?ccg?cgc?ctg?tgt?gcg?gaa?tcc?tcc 1267

Asn?Ala?Ala?Val?Lys?Asp?Thr?Val?Pro?Arg?Leu?Cys?Ala?Glu?Ser?Ser

375 380 385

gac?cgc?att?cca?aag?tgg?ctg?ttg?cca?gtc?gta?cgc?gaa?aac?ctc?gca 1315

Asp?Arg?Ile?Pro?Lys?Trp?Leu?Leu?Pro?Val?Val?Arg?Glu?Asn?Leu?Ala

390 395 400 405

gca?ggc?cgc?gac?gtc?aca?ctt?tct?gca?gcc?atc?gtc?gca?tcc?tgg?gcg 1363

Ala?Gly?Arg?Asp?Val?Thr?Leu?Ser?Ala?Ala?Ile?Val?Ala?Ser?Trp?Ala

410 415 420

cgc?tac?gca?gaa?ggc?acc?gac?gag?cag?ggc?aac?cca?ata?aag?att?gtt 1411

Arg?Tyr?Ala?Glu?Gly?Thr?Asp?Glu?Gln?Gly?Asn?Pro?Ile?Lys?Ile?Val

425 430 435

gac?cgt?ttg?agt?gag?cgc?gtc?caa?gaa?aac?gca?tca?gga?aat?cgc?acc 1459

Asp?Arg?Leu?Ser?Glu?Arg?Val?Gln?Glu?Asn?Ala?Ser?Gly?Asn?Arg?Thr

440 445 450

gat?att?ttg?tca?ttc?atc?cgc?gac?cgt?gga?atc?ttc?gga?gac?ttg?gtc 1507

Asp?Ile?Leu?Ser?Phe?Ile?Arg?Asp?Arg?Gly?Ile?Phe?Gly?Asp?Leu?Val

455 460 465

gat?gct?gaa?cca?ttc?acc?aag?gca?tac?tcc?gag?aca?ctg?tcc?tcc?ctt 1555

Asp?Ala?Glu?Pro?Phe?Thr?Lys?Ala?Tyr?Ser?Glu?Thr?Leu?Ser?Ser?Leu

470 475 480 485

cat?gac?cgt?ggc?gcg?gaa?gca?acc?atc?gat?gca?ctt?ctt?acg?cag?gta 1603

His?Asp?Arg?Gly?Ala?Glu?Ala?Thr?Ile?Asp?Ala?Leu?Leu?Thr?Gln?Val

490 495 500

act?gtc?taaatccgtt?gcgcgctagg?gtt 1632

Thr?Val

<210>336

<211>503

<212>PRT

＜213〉Corynebacterium glutamicum

<400>336

Met?Asn?Thr?Pro?Leu?Gln?Leu?Asn?Thr?Glu?Asn?Leu?Gln?Glu?Ile?Ala

1 5 10 15

Ser?Thr?Ser?Gly?Val?Gln?Ile?Pro?Ala?Phe?Asn?Arg?Ala?Asp?Val?Ala

20 25 30

Pro?Gly?Ile?Val?His?Phe?Gly?Val?Gly?Gly?Phe?His?Arg?Ala?His?Gln

35 40 45

Ala?Met?Tyr?Leu?Asn?Glu?Leu?Met?Asn?Glu?Gly?Lys?Ala?Leu?Asp?Trp

50 55 60

Gly?Ile?Ile?Gly?Met?Gly?Val?Met?Pro?Ser?Asp?Val?Arg?Met?Arg?Asp

65 70 75 80

Ala?Leu?Ala?Ser?Gln?Asp?His?Leu?Tyr?Thr?Leu?Thr?Thr?Lys?Ala?Pro

85 90 95

Asp?Gly?Thr?Leu?Asp?Gln?Lys?Ile?Ile?Gly?Ser?Ile?Ile?Asp?Tyr?Val

100 105 110

Phe?Ala?Pro?Glu?Asp?Pro?Ala?Arg?Ala?Val?Ala?Thr?Leu?Ala?Gln?Asp

115 120 125

Ser?Ile?Arg?Ile?Val?Ser?Leu?Thr?Val?Thr?Glu?Gly?Gly?Tyr?Asn?Ile

130 135 140

Asp?Pro?Ala?Thr?Glu?Asp?Phe?Asp?His?Thr?Asn?Pro?Arg?Ile?Val?Ala

145 150 155 160

Asp?Arg?Glu?Ala?Leu?Gln?Ala?Gly?Asp?Thr?Ser?Thr?Leu?Gln?Thr?Phe

165 170 175

Phe?Gly?Leu?Ile?Thr?Ala?Ala?Leu?Ile?Ser?Arg?Lys?Glu?Ser?Gly?Ser

180 185 190

Thr?Pro?Phe?Thr?Ile?Met?Ser?Cys?Asp?Asn?Ile?Gln?Gly?Asn?Gly?Asp

195 200 205

Leu?Ala?Lys?Arg?Phe?Phe?Leu?Ala?Phe?Ala?His?Ser?Val?Ser?Ser?Glu

210 215 220

Leu?Gly?Glu?Trp?Val?Glu?Asn?Asn?Val?Ala?Phe?Pro?Asn?Ser?Met?Val

225 230 235 240

Asp?Arg?Ile?Thr?Pro?Glu?Thr?Thr?Asp?Gly?Asp?Arg?Asp?Asp?Ile?Lys

245 250 255

Glu?Ile?Gly?Tyr?Ile?Asp?Ala?Trp?Pro?Val?Val?Ser?Glu?Asp?Phe?Thr

260 265 270

Gln?Trp?Val?Leu?Glu?Asp?Ala?Phe?Thr?Gln?Gly?Arg?Pro?Ala?Tyr?Glu

275 280 285

Glu?Val?Gly?Val?Gln?Val?Val?Ser?Asp?Val?Glu?Pro?Tyr?Glu?Leu?Met

290 295 300

Lys?Leu?Arg?Leu?Leu?Asn?Ala?Ser?His?Gln?Gly?Leu?Cys?Tyr?Phe?Gly

305 310 315 320

His?Leu?Ala?Gly?His?His?Met?Val?His?Asp?Val?Met?Ala?Asp?Thr?Arg

325 330 335

Phe?Gln?Asp?Phe?Leu?Leu?Ala?Tyr?Met?Glu?Arg?Glu?Ala?Thr?Pro?Thr

340 345 350

Leu?Lys?Glu?Leu?Pro?Gly?Val?Asp?Leu?Asp?Ala?Tyr?Arg?Arg?Gln?Leu

355 360 365

Ile?Ala?Arg?Phe?Gly?Asn?Ala?Ala?Val?Lys?Asp?Thr?Val?Pro?Arg?Leu

370 375 380

Cys?Ala?Glu?Ser?Ser?Asp?Arg?Ile?Pro?Lys?Trp?Leu?Leu?Pro?Val?Val

385 390 395 400

Arg?Glu?Asn?Leu?Ala?Ala?Gly?Arg?Asp?Val?Thr?Leu?Ser?Ala?Ala?Ile

405 410 415

Val?Ala?Ser?Trp?Ala?Arg?Tyr?Ala?Glu?Gly?Thr?Asp?Glu?Gln?Gly?Asn

420 425 430

Pro?Ile?Lys?Ile?Val?Asp?Arg?Leu?Ser?Glu?Arg?Val?Gln?Glu?Asn?Ala

435 440 445

Ser?Gly?Asn?Arg?Thr?Asp?Ile?Leu?Ser?Phe?Ile?Arg?Asp?Arg?Gly?Ile

450 455 460

Phe?Gly?Asp?Leu?Val?Asp?Ala?Glu?Pro?Phe?Thr?Lys?Ala?Tyr?Ser?Glu

465 470 475 480

Thr?Leu?Ser?Ser?Leu?His?Asp?Arg?Gly?Ala?Glu?Ala?Thr?Ile?Asp?Ala

485 490 495

Leu?Leu?Thr?Gln?Val?Thr?Val

500

<210>337

<211>1098

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1075)

<223>RXA02528

<400>337

ctggcgcggt?atcgattaca?atctggttgg?ttatcggtgg?tttgtggatg?aatgtcatcg?60

gactctggta?atcgaaaatt?aaaggtaagg?gggtgtggag?atg?tca?gca?aaa?tcg 115

Met?Ser?Ala?Lys?Ser

1 5

agc?ctc?aag?gaa?gtt?gct?gag?tta?gct?gga?gtc?ggt?tat?gcc?aca?gcc 163

Ser?Leu?Lys?Glu?Val?Ala?Glu?Leu?Ala?Gly?Val?Gly?Tyr?Ala?Thr?Ala

10 15 20

tcg?agg?gca?cta?tct?ggc?aag?ggg?tat?gtg?tcc?ccg?cag?acg?cgg?gag 211

Ser?Arg?Ala?Leu?Ser?Gly?Lys?Gly?Tyr?Val?Ser?Pro?Gln?Thr?Arg?Glu

25 30 35

aaa?gtt?cag?gcg?gcg?gct?aaa?gag?ctg?aac?tat?gta?cca?aat?cag?ctg 259

Lys?Val?Gln?Ala?Ala?Ala?Lys?Glu?Leu?Asn?Tyr?Val?Pro?Asn?Gln?Leu

40 45 50

gcc?aag?gcg?ttg?cgg?gaa?cat?cgc?agt?gcc?ttg?gtg?ggg?gtc?att?gtt 307

Ala?Lys?Ala?Leu?Arg?Glu?His?Arg?Ser?Ala?Leu?Val?Gly?Val?Ile?Val

55 60 65

ccg?gat?ttg?tcc?aat?gag?tat?tat?tcg?gaa?tcg?ctg?cag?act?att?cag 355

Pro?Asp?Leu?Ser?Asn?Glu?Tyr?Tyr?Ser?Glu?Ser?Leu?Gln?Thr?Ile?Gln

70 75 80 85

cag?gat?ctg?aaa?gct?gct?ggc?tat?caa?atg?ctg?gtt?gcg?gag?gcc?aac 403

Gln?Asp?Leu?Lys?Ala?Ala?Gly?Tyr?Gln?Met?Leu?Val?Ala?Glu?Ala?Asn

90 95 100

agt?gtg?cag?gcg?cag?gac?gtg?gtg?atg?gaa?tcg?ttg?atc?tcg?att?caa 451

Ser?Val?Gln?Ala?Gln?Asp?Val?Val?Met?Glu?Ser?Leu?Ile?Ser?Ile?Gln

105 110 115

gct?gca?gga?att?atc?cac?gtt?cca?gtg?gtc?ggc?tca?att?gct?cct?gaa 499

Ala?Ala?Gly?Ile?Ile?His?Val?Pro?Val?Val?Gly?Ser?Ile?Ala?Pro?Glu

120 125 130

gga?atc?ccc?atg?gtg?cag?ttg?act?cgt?ggt?gaa?ttg?ggt?cct?ggt?ttc 547

Gly?Ile?Pro?Met?Val?Gln?Leu?Thr?Arg?Gly?Glu?Leu?Gly?Pro?Gly?Phe

135 140 145

cct?cgg?gtg?ttg?tgt?gat?gat?gag?gct?ggg?ttt?ttt?cag?ctg?acc?gag 595

Pro?Arg?Val?Leu?Cys?Asp?Asp?Glu?Ala?Gly?Phe?Phe?Gln?Leu?Thr?Glu

150 155 160 165

tcg?gtg?ctg?ggc?ggc?agc?gga?atg?aac?att?gct?gct?ttg?gtt?ggt?gaa 643

Ser?Val?Leu?Gly?Gly?Ser?Gly?Met?Asn?Ile?Ala?Ala?Leu?Val?Gly?Glu

170 175 180

gaa?tca?ctt?tcc?acc?acg?cag?gaa?cga?atg?cgc?ggt?att?agt?cat?gcg 691

Glu?Ser?Leu?Ser?Thr?Thr?Gln?Glu?Arg?Met?Arg?Gly?Ile?Ser?His?Ala

185 190 195

gcg?tcg?ata?tat?ggg?gct?gag?gtg?acg?ttc?cat?ttt?ggc?cac?tat?tct 739

Ala?Ser?Ile?Tyr?Gly?Ala?Glu?Val?Thr?Phe?His?Phe?Gly?His?Tyr?Ser

200 205 210

gtc?gaa?tct?ggc?gaa?gag?atg?gct?cag?gtg?gtg?ttt?aac?aac?ggc?ctt 787

Val?Glu?Ser?Gly?Glu?Glu?Met?Ala?Gln?Val?Val?Phe?Asn?Asn?Gly?Leu

215 220 225

ccc?gat?gca?ttg?att?gtg?gcg?tct?cct?cgg?ctg?atg?gct?ggg?gtg?atg 835

Pro?Asp?Ala?Leu?Ile?Val?Ala?Ser?Pro?Arg?Leu?Met?Ala?Gly?Val?Met

230 235 240 245

cgt?gct?ttt?act?cgc?ctg?aat?gtc?cgc?gtt?ccc?cac?gat?gtg?gtg?att 883

Arg?Ala?Phe?Thr?Arg?Leu?Asn?Val?Arg?Val?Pro?His?Asp?Val?Val?Ile

250 255 260

ggt?ggt?tat?gac?gat?cct?gag?tgg?tac?agc?ttt?gtc?ggc?gcg?ggg?att 931

Gly?Gly?Tyr?Asp?Asp?Pro?Glu?Trp?Tyr?Ser?Phe?Val?Gly?Ala?Gly?Ile

265 270 275

acc?acg?ttt?gtt?cca?ccg?cat?gag?gag?atg?ggg?aaa?gag?gcc?gtg?cgc 979

Thr?Thr?Phe?Val?Pro?Pro?His?Glu?Glu?Met?Gly?Lys?Glu?Ala?Val?Arg

280 285 290

ttg?ttg?gta?gat?ctg?att?gaa?aat?ccc?gaa?ctt?ccc?acc?ggc?gat?gtg 1027

Leu?Leu?Val?Asp?Leu?Ile?Glu?Asn?Pro?Glu?Leu?Pro?Thr?Gly?Asp?Val

295 300 305

gtt?ttg?cag?ggg?cag?gtg?atc?ctt?cgg?ggg?tcg?agc?aca?cat?tcc?ggg 1075

Val?Leu?Gln?Gly?Gln?Val?Ile?Leu?Arg?Gly?Ser?Ser?Thr?His?Ser?Gly

310 315 320 325

tagaattgcc?caaatgtcat?caa 1098

<210>338

<211>325

<212>PRT

＜213〉Corynebacterium glutamicum

<400>338

Met?Ser?Ala?Lys?Ser?Ser?Leu?Lys?Glu?Val?Ala?Glu?Leu?Ala?Gly?Val

1 5 10 15

Gly?Tyr?Ala?Thr?Ala?Ser?Arg?Ala?Leu?Ser?Gly?Lys?Gly?Tyr?Val?Ser

20 25 30

Pro?Gln?Thr?Arg?Glu?Lys?Val?Gln?Ala?Ala?Ala?Lys?Glu?Leu?Asn?Tyr

35 40 45

Val?Pro?Asn?Gln?Leu?Ala?Lys?Ala?Leu?Arg?Glu?His?Arg?Ser?Ala?Leu

50 55 60

Val?Gly?Val?Ile?Val?Pro?Asp?Leu?Ser?Asn?Glu?Tyr?Tyr?Ser?Glu?Ser

65 70 75 80

Leu?Gln?Thr?Ile?Gln?Gln?Asp?Leu?Lys?Ala?Ala?Gly?Tyr?Gln?Met?Leu

85 90 95

Val?Ala?Glu?Ala?Asn?Ser?Val?Gln?Ala?Gln?Asp?Val?Val?Met?Glu?Ser

100 105 110

Leu?Ile?Ser?Ile?Gln?Ala?Ala?Gly?Ile?Ile?His?Val?Pro?Val?Val?Gly

115 120 125

Ser?Ile?Ala?Pro?Glu?Gly?Ile?Pro?Met?Val?Gln?Leu?Thr?Arg?Gly?Glu

130 135 140

Leu?Gly?Pro?Gly?Phe?Pro?Arg?Val?Leu?Cys?Asp?Asp?Glu?Ala?Gly?Phe

145 150 155 160

Phe?Gln?Leu?Thr?Glu?Ser?Val?Leu?Gly?Gly?Ser?Gly?Met?Asn?Ile?Ala

165 170 175

Ala?Leu?Val?Gly?Glu?Glu?Ser?Leu?Ser?Thr?Thr?Gln?Glu?Arg?Met?Arg

180 185 190

Gly?Ile?Ser?His?Ala?Ala?Ser?Ile?Tyr?Gly?Ala?Glu?Val?Thr?Phe?His

195 200 205

Phe?Gly?His?Tyr?Ser?Val?Glu?Ser?Gly?Glu?Glu?Met?Ala?Gln?Val?Val

210 215 220

Phe?Asn?Asn?Gly?Leu?Pro?Asp?Ala?Leu?Ile?Val?Ala?Ser?Pro?Arg?Leu

225 230 235 240

Met?Ala?Gly?Val?Met?Arg?Ala?Phe?Thr?Arg?Leu?Asn?Val?Arg?Val?Pro

245 250 255

His?Asp?Val?Val?Ile?Gly?Gly?Tyr?Asp?Asp?Pro?Glu?Trp?Tyr?Ser?Phe

260 265 270

Val?Gly?Ala?Gly?Ile?Thr?Thr?Phe?Val?Pro?Pro?His?Glu?Glu?Met?Gly

275 280 285

Lys?Glu?Ala?Val?Arg?Leu?Leu?Val?Asp?Leu?Ile?Glu?Asn?Pro?Glu?Leu

290 295 300

Pro?Thr?Gly?Asp?Val?Val?Leu?Gln?Gly?Gln?Val?Ile?Leu?Arg?Gly?Ser

305 310 315 320

Ser?Thr?His?Ser?Gly

325

<210>339

<211>1246

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1246)

<223>RXN00316

<400>339

agcgcatgat?cgatgcctgc?gagtccgcag?gggtccaact?tggcgtgctc?ttccagcgcc?60

gcttctggcc?cgcggctcaa?aaaatgaaaa?aggagccgtc?atg?ggc?caa?tgc?acg 115

Met?Gly?Gln?Cys?Thr

1 5

gta?gcg?ctt?tac?cga?gag?cat?tcc?tat?tac?aca?gca?acc?cca?tgg?cga 163

Val?Ala?Leu?Tyr?Arg?Glu?His?Ser?Tyr?Tyr?Thr?Ala?Thr?Pro?Trp?Arg

10 15 20

gga?acc?tgg?gca?gcc?gat?ggc?ggt?gga?gtg?ctc?atg?act?caa?gcc?atc 211

Gly?Thr?Trp?Ala?Ala?Asp?Gly?Gly?Gly?Val?Leu?Met?Thr?Gln?Ala?Ile

25 30 35

cac?tac?atc?gat?ctt?ttg?tac?tgg?ctg?ttg?ggc?gaa?ccc?gtg?gaa?gtt 259

His?Tyr?Ile?Asp?Leu?Leu?Tyr?Trp?Leu?Leu?Gly?Glu?Pro?Val?Glu?Val

40 45 50

ttc?ggc?tac?acc?aac?tcc?ttc?aaa?cac?ggc?gac?aac?atc?gaa?gtc?gaa 307

Phe?Gly?Tyr?Thr?Asn?Ser?Phe?Lys?His?Gly?Asp?Asn?Ile?Glu?Val?Glu

55 60 65

gac?agc?gcc?gtt?gcc?act?gtg?cgt?ttt?gaa?tcg?ggc?gcg?ttg?gcc?aca 355

Asp?Ser?Ala?Val?Ala?Thr?Val?Arg?Phe?Glu?Ser?Gly?Ala?Leu?Ala?Thr

70 75 80 85

att?tca?gcc?acc?acc?gcc?gca?gag?cea?gca?ctc?ggc?gca?caa?gtg?cag 403

Ile?Ser?Ala?Thr?Thr?Ala?Ala?Glu?Pro?Ala?Leu?Gly?Ala?Gln?Val?Gln

90 95 100

gtg?atg?gga?aca?aag?ggt?gcc?acc?atg?acg?atc?ctg?gaa?ttc?cct?gaa 451

Val?Met?Gly?Thr?Lys?Gly?Ala?Thr?Met?Thr?Ile?Leu?Glu?Phe?Pro?Glu

105 110 115

ggt?acc?gac?ggc?agg?ctc?att?gtt?cgc?agt?gaa?aac?gac?acc?cgt?cga 499

Gly?Thr?Asp?Gly?Arg?Leu?Ile?Val?Arg?Ser?Glu?Asn?Asp?Thr?Arg?Arg

120 125 130

aac?cac?ccc?att?cca?ccc?cgc?gga?tct?tta?tcc?caa?tgc?cga?tct?ttc 547

Asn?His?Pro?Ile?Pro?Pro?Arg?Gly?Ser?Leu?Ser?Gln?Cys?Arg?Ser?Phe

135 140 145

cat?cat?caa?cgg?tgc?ttt?gat?ccc?gta?tca?cac?cgc?cca?gat?cgc?aga 595

His?His?Gln?Arg?Cys?Phe?Asp?Pro?Val?Ser?His?Arg?Pro?Asp?Arg?Arg

150 155 160 165

ctt?tat?cga?tgc?gct?caa?cga?agg?ccg?ccc?acc?act?gat?cac?cgg?ccg 643

Leu?Tyr?Arg?Cys?Ala?Gln?Arg?Arg?Pro?Pro?Thr?Thr?Asp?His?Arg?Pro

170 175 180

cga?tgc?cac?cag?agc?tct?gaa?agt?tct?cct?tgg?tgt?cta?cga?atc?agc 691

Arg?Cys?His?Gln?Ser?Ser?Glu?Ser?Ser?Pro?Trp?Cys?Leu?Arg?Ile?Ser

185 190 195

agc?cac?cca?cca?gcc?ggt?ctc?ttt?gat?cta?acg?gaa?gct?ttt?aaa?acg 739

Ser?His?Pro?Pro?Ala?Gly?Leu?Phe?Asp?Leu?Thr?Glu?Ala?Phe?Lys?Thr

200 205 210

tca?cgc?caa?atc?ggt?ctt?gca?cct?tta?tcc?tcc?ctg?tcc?aca?cca?cct 787

Ser?Arg?Gln?Ile?Gly?Leu?Ala?Pro?Leu?Ser?Ser?Leu?Ser?Thr?Pro?Pro

215 220 225

gat?caa?cta?gtg?cgc?ctc?gca?gct?gcc?act?ggt?ttc?tcc?ttt?gtc?ggt 835

Asp?Gln?Leu?Val?Arg?Leu?Ala?Ala?Ala?Thr?Gly?Phe?Ser?Phe?Val?Gly

230 235 240 245

ctg?cgc?gtc?atc?gca?gta?acc?ccc?aac?gaa?cgt?gta?tat?gac?ctt?tcc 883

Leu?Arg?Val?Ile?Ala?Val?Thr?Pro?Asn?Glu?Arg?Val?Tyr?Asp?Leu?Ser

250 255 260

cca?gga?tcc?cca?ctg?ctg?gct?gca?acc?caa?caa?gcg?ttg?aaa?gaa?acc 931

Pro?Gly?Ser?Pro?Leu?Leu?Ala?Ala?Thr?Gln?Gln?Ala?Leu?Lys?Glu?Thr

265 270 275

gcc?ctg?tat?gtg?ctc?gac?act?gaa?ttc?cta?cag?gta?aac?gca?gac?acc 979

Ala?Leu?Tyr?Val?Leu?Asp?Thr?Glu?Phe?Leu?Gln?Val?Asn?Ala?Asp?Thr

280 285 290

acc?cgc?gag?gcc?tgg?ctt?ccc?gca?cta?gaa?gcc?gcc?gga?gca?ctg?gga 1027

Thr?Arg?Glu?Ala?Trp?Leu?Pro?Ala?Leu?Glu?Ala?Ala?Gly?Ala?Leu?Gly

295 300 305

gct?aaa?acc?ttc?acc?atc?gcc?gcc?ggt?gat?gac?aac?att?gcg?ccc?ctg 1075

Ala?Lys?Thr?Phe?Thr?Ile?Ala?Ala?Gly?Asp?Asp?Asn?Ile?Ala?Pro?Leu

310 315 320 325

acc?gac?acg?atc?ggt?gcc?atg?gtt?gac?gat?gcc?cgt?gat?ttc?gga?gtc 1123

Thr?Asp?Thr?Ile?Gly?Ala?Met?Val?Asp?Asp?Ala?Arg?Asp?Phe?Gly?Val

330 335 340

acc?cca?gcc?cta?gag?cca?atc?tct?tac?cgc?agc?gtg?cat?tcc?att?ccg 1171

Thr?Pro?Ala?Leu?Glu?Pro?Ile?Ser?Tyr?Arg?Ser?Val?His?Ser?Ile?Pro

345 350 355

cag?gca?gca?gca?atc?gcc?aga?gac?tcc?ggc?gga?aaa?gtc?gtg?gcg?gac 1219

Gln?Ala?Ala?Ala?Ile?Ala?Arg?Asp?Ser?Gly?Gly?Lys?Val?Val?Ala?Asp

360 365 370

acc?ttg?cac?atg?gcc?agg?ttc?gga?gcc 1246

Thr?Leu?His?Met?Ala?Arg?Phe?Gly?Ala

375 380

<210>340

<211>382

<212>PRT

＜213〉Corynebacterium glutamicum

<400>340

Met?Gly?Gln?Cys?Thr?Val?Ala?Leu?Tyr?Arg?Glu?His?Ser?Tyr?Tyr?Thr

1 5 10 15

Ala?Thr?Pro?Trp?Arg?Gly?Thr?Trp?Ala?Ala?Asp?Gly?Gly?Gly?Val?Leu

20 25 30

Met?Thr?Gln?Ala?Ile?His?Tyr?Ile?Asp?Leu?Leu?Tyr?Trp?Leu?Leu?Gly

35 40 45

Glu?Pro?Val?Glu?Val?Phe?Gly?Tyr?Thr?Asn?Ser?Phe?Lys?His?Gly?Asp

50 55 60

Asn?Ile?Glu?Val?Glu?Asp?Ser?Ala?Val?Ala?Thr?Val?Arg?Phe?Glu?Ser

65 70 75 80

Gly?Ala?Leu?Ala?Thr?Ile?Ser?Ala?Thr?Thr?Ala?Ala?Glu?Pro?Ala?Leu

85 90 95

Gly?Ala?Gln?Val?Gln?Val?Met?Gly?Thr?Lys?Gly?Ala?Thr?Met?Thr?Ile

100 105 110

Leu?Glu?Phe?Pro?Glu?Gly?Thr?Asp?Gly?Arg?Leu?Ile?Val?Arg?Ser?Glu

115 120 125

Asn?Asp?Thr?Arg?Arg?Asn?His?Pro?Ile?Pro?Pro?Arg?Gly?Ser?Leu?Ser

130 135 140

Gln?Cys?Arg?Ser?Phe?His?His?Gln?Arg?Cys?Phe?Asp?Pro?Val?Ser?His

145 150 155 160

Arg?Pro?Asp?Arg?Arg?Leu?Tyr?Arg?Cys?Ala?Gln?Arg?Arg?Pro?Pro?Thr

165 170 175

Thr?Asp?His?Arg?Pro?Arg?Cys?His?Gln?Ser?Ser?Glu?Ser?Ser?Pro?Trp

180 185 190

Cys?Leu?Arg?Ile?Ser?Ser?His?Pro?Pro?Ala?Gly?Leu?Phe?Asp?Leu?Thr

195 200 205

Glu?Ala?Phe?Lys?Thr?Ser?Arg?Gln?Ile?Gly?Leu?Ala?Pro?Leu?Ser?Ser

210 215 220

Leu?Ser?Thr?Pro?Pro?Asp?Gln?Leu?Val?Arg?Leu?Ala?Ala?Ala?Thr?Gly

225 230 235 240

Phe?Ser?Phe?Val?Gly?Leu?Arg?Val?Ile?Ala?Val?Thr?Pro?Asn?Glu?Arg

245 250 255

Val?Tyr?Asp?Leu?Ser?Pro?Gly?Ser?Pro?Leu?Leu?Ala?Ala?Thr?Gln?Gln

260 265 270

Ala?Leu?Lys?Glu?Thr?Ala?Leu?Tyr?Val?Leu?Asp?Thr?Glu?Phe?Leu?Gln

275 280 285

Val?Asn?Ala?Asp?Thr?Thr?Arg?Glu?Ala?Trp?Leu?Pro?Ala?Leu?Glu?Ala

290 295 300

Ala?Gly?Ala?Leu?Gly?Ala?Lys?Thr?Phe?Thr?Ile?Ala?Ala?Gly?Asp?Asp

305 310 315 320

Asn?Ile?Ala?Pro?Leu?Thr?Asp?Thr?Ile?Gly?Ala?Met?Val?Asp?Asp?Ala

325 330 335

Arg?Asp?Phe?Gly?Val?Thr?Pro?Ala?Leu?Glu?Pro?Ile?Ser?Tyr?Arg?Ser

340 345 350

Val?His?Ser?Ile?Pro?Gln?Ala?Ala?Ala?Ile?Ala?Arg?Asp?Ser?Gly?Gly

355 360 365

Lys?Val?Val?Ala?Asp?Thr?Leu?His?Met?Ala?Arg?Phe?Gly?Ala

370 375 380

<210>341

<211>412

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(412)

<223>FRXA00309

<400>341

agcgcatgat?cgatgcctgc?gagtccgcag?gggtccaact?tggcgtgctc?ttccagcgcc?60

gcttctggcc?cgcggctcaa?aaaatgaaaa?aggagccgtc?atg?ggc?caa?tgc?acg 115

Met?Gly?Gln?Cys?Thr

1 5

gta?gcg?ctt?tac?cga?gag?cat?tcc?tat?tac?aca?gca?acc?cca?tgg?cga 163

Val?Ala?Leu?Tyr?Arg?Glu?His?Ser?Tyr?Tyr?Thr?Ala?Thr?Pro?Trp?Arg

10 15 20

gga?acc?tgg?gca?gcc?gat?ggc?ggt?gga?gtg?ctc?atg?act?caa?gcc?atc 211

Gly?Thr?Trp?Ala?Ala?Asp?Gly?Gly?Gly?Val?Leu?Met?Thr?Gln?Ala?Ile

25 30 35

cac?tac?atc?gat?ctt?ttg?tac?tgg?ctg?ttg?ggc?gaa?ccc?gtg?gaa?gtt 259

His?Tyr?Ile?Asp?Leu?Leu?Tyr?Trp?Leu?Leu?Gly?Glu?Pro?Val?Glu?Val

40 45 50

ttc?ggc?tac?acc?aac?tcc?ttc?aaa?cac?ggc?gac?aac?atc?gaa?gtc?gaa 307

Phe?Gly?Tyr?Thr?Asn?Ser?Phe?Lys?His?Gly?Asp?Asn?Ile?Glu?Val?Glu

55 60 65

gac?agc?gcc?gtt?gcc?act?gtg?cgt?ttt?gaa?tcg?ggc?gcg?ttg?gcc?aca 355

Asp?Ser?Ala?Val?Ala?Thr?Val?Arg?Phe?Glu?Ser?Gly?Ala?Leu?Ala?Thr

70 75 80 85

att?tca?gcc?acc?acc?gcc?gca?gag?cca?gca?ctc?ggc?gca?caa?gtg?cag 403

Ile?Ser?Ala?Thr?Thr?Ala?Ala?Glu?Pro?Ala?Leu?Gly?Ala?Gln?Val?Gln

90 95 100

gtg?atg?gga 412

Val?Met?Gly

<210>342

<211>104

<212>PRT

＜213〉Corynebacterium glutamicum

<400>342

Met?Gly?Gln?Cys?Thr?Val?Ala?Leu?Tyr?Arg?Glu?His?Ser?Tyr?Tyr?Thr

1 5 10 15

Ala?Thr?Pro?Trp?Arg?Gly?Thr?Trp?Ala?Ala?Asp?Gly?Gly?Gly?Val?Leu

20 25 30

Met?Thr?Gln?Ala?Ile?His?Tyr?Ile?Asp?Leu?Leu?Tyr?Trp?Leu?Leu?Gly

35 40 45

Glu?Pro?Val?Glu?Val?Phe?Gly?Tyr?Thr?Asn?Ser?Phe?Lys?His?Gly?Asp

50 55 60

Asn?Ile?Glu?Val?Glu?Asp?Ser?Ala?Val?Ala?Thr?Val?Arg?Phe?Glu?Ser

65 70 75 80

Gly?Ala?Leu?Ala?Thr?Ile?Ser?Ala?Thr?Thr?Ala?Ala?Glu?Pro?Ala?Leu

85 90 95

Gly?Ala?Gln?Val?Gln?Val?Met?Gly

100

<210>343

<211>558

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(535)

<223>RXN00310

<400>343

ttgcgggatt?catcatcggc?gcaatcgcac?tgtctgccgc?agttattttg?accaccaagg?60

aaaccgcctt?caccaagctt?gaagatctag?ggaagaaata?atg?tct?gac?aag?atc 115

Met?Ser?Asp?Lys?Ile

1 5

tgg?aaa?gtc?ggc?atc?atc?ggt?tgc?ggt?gca?atc?agc?cga?aac?cat?atc 163

Trp?Lys?Val?Gly?Ile?Ile?Gly?Cys?Gly?Ala?Ile?Ser?Arg?Asn?His?Ile

10 15 20

gaa?gca?gtt?cag?gca?atc?ccc?ggc?gca?gaa?gtc?agc?gca?gtc?tgt?gat 211

Glu?Ala?Val?Gln?Ala?Ile?Pro?Gly?Ala?Glu?Val?Ser?Ala?Val?Cys?Asp

25 30 35

gtg?gat?ggt?gcg?aaa?gca?tcg?gaa?acc?gca?gcg?aaa?tat?gga?att?tct 259

Val?Asp?Gly?Ala?Lys?Ala?Ser?Glu?Thr?Ala?Ala?Lys?Tyr?Gly?Ile?Ser

40 45 50

ccc?agt?ttc?acg?tct?gtc?gat?gag?atc?ctc?gcc?tcc?ggg?gtg?gac?att 307

Pro?Ser?Phe?Thr?Ser?Val?Asp?Glu?Ile?Leu?Ala?Ser?Gly?Val?Asp?Ile

55 60 65

gtc?gca?gtc?tgc?acc?cca?cat?cca?acc?cac?gaa?aca?gtg?gtc?ctc?gcc 355

Val?Ala?Val?Cys?Thr?Pro?His?Pro?Thr?His?Glu?Thr?Val?Val?Leu?Ala

70 75 80 85

gct?gct?gcc?gcc?gga?gtg?cac?gtg?ctt?tgt?gag?aag?cca?atc?gcc?atc 403

Ala?Ala?Ala?Ala?Gly?Val?His?Val?Leu?Cys?Glu?Lys?Pro?lle?Ala?Ile

90 95 100

gaa?ctc?gat?tcc?gca?cag?cgc?atg?atc?gat?gcc?tgc?gag?tcc?gca?ggg 451

Glu?Leu?Asp?Ser?Ala?Gln?Arg?Met?Ile?Asp?Ala?Cys?Glu?Ser?Ala?Gly

105 110 115

gtc?caa?ctt?ggc?gtg?ctc?ttc?cag?cgc?cgc?ttc?tgg?ccc?gcg?gct?caa 499

Val?Gln?Leu?Gly?Val?Leu?Phe?Gln?Arg?Arg?Phe?Trp?Pro?Ala?Ala?Gln

120 125 130

aaa?atg?aaa?aag?gag?ccg?tca?tgg?gcc?aat?gca?cgg?tagcgcttta 545

Lys?Met?Lys?Lys?Glu?Pro?Ser?Trp?Ala?Asn?Ala?Arg

135 140 145

ccgagagcat?tcc 558

<210>344

<211>145

<212>PRT

＜213〉Corynebacterium glutamicum

<400>344

Met?Ser?Asp?Lys?Ile?Trp?Lys?Val?Gly?Ile?Ile?Gly?Cys?Gly?Ala?Ile

1 5 10 15

Ser?Arg?Asn?His?Ile?Glu?Ala?Val?Gln?Ala?Ile?Pro?Gly?Ala?Glu?Val

20 25 30

Ser?Ala?Val?Cys?Asp?Val?Asp?Gly?Ala?Lys?Ala?Ser?Glu?Thr?Ala?Ala

35 40 45

Lys?Tyr?Gly?Ile?Ser?Pro?Ser?Phe?Thr?Ser?Val?Asp?Glu?Ile?Leu?Ala

50 55 60

Ser?Gly?Val?Asp?Ile?Val?Ala?Val?Cys?Thr?Pro?His?Pro?Thr?His?Glu

65 70 75 80

Thr?Val?Val?Leu?Ala?Ala?Ala?Ala?Ala?Gly?Val?His?Val?Leu?Cys?Glu

85 90 95

Lys?Pro?Ile?Ala?Ile?Glu?Leu?Asp?Ser?Ala?Gln?Arg?Met?Ile?Asp?Ala

100 105 110

Cys?Glu?Ser?Ala?Gly?Val?Gln?Leu?Gly?Val?Leu?Phe?Gln?Arg?Arg?Phe

115 120 125

Trp?Pro?Ala?Ala?Gln?Lys?Met?Lys?Lys?Glu?Pro?Ser?Trp?Ala?Asn?Ala

130 135 140

Arg

145

<210>345

<211>558

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(535)

<223>FRXA00310

<400>345

ttgcgggatt?catcatcggc?gcaatcgcac?tgtctgccgc?agttattttg?accaccaagg?60

aaaccgcctt?caccaagctt?gaagatctag?ggaagaaata?atg?tct?gac?aag?atc 115

Met?Ser?Asp?Lys?Ile

1 5

tgg?aaa?gtc?ggc?atc?atc?ggt?tgc?ggt?gca?atc?agc?cga?aac?cat?atc 163

Trp?Lys?Val?Gly?Ile?Ile?Gly?Cys?Gly?Ala?Ile?Ser?Arg?Asn?His?Ile

10 15 20

gaa?gca?gtt?cag?gca?atc?ccc?ggc?gca?gaa?gtc?agc?gca?gtc?tgt?gat 211

Glu?Ala?Val?Gln?Ala?Ile?Pro?Gly?Ala?Glu?Val?Ser?Ala?Val?Cys?Asp

25 30 35

gtg?gat?ggt?gcg?aaa?gca?tcg?gaa?acc?gca?gcg?aaa?tat?gga?att?tct 259

Val?Asp?Gly?Ala?Lys?Ala?Ser?Glu?Thr?Ala?Ala?Lys?Tyr?Gly?Ile?Ser

40 45 50

ccc?agt?ttc?acg?tct?gtc?gat?gag?atc?ctc?gcc?tcc?ggg?gtg?gac?att 307

Pro?Ser?Phe?Thr?Ser?Val?Asp?Glu?Ile?Leu?Ala?Ser?Gly?Val?Asp?Ile

55 60 65

gtc?gca?gtc?tgc?acc?cca?cat?cca?acc?cac?gaa?aca?gtg?gtc?ctc?gcc 355

Val?Ala?Val?Cys?Thr?Pro?His?Pro?Thr?His?Glu?Thr?Val?Val?Leu?Ala

70 75 80 85

gct?gct?gcc?gcc?gga?gtg?cac?gtg?ctt?tgt?gag?aag?cca?atc?gcc?atc 403

Ala?Ala?Ala?Ala?Gly?Val?His?Val?Leu?Cys?Glu?Lys?Pro?Ile?Ala?Ile

90 95 100

gaa?ctc?gat?tcc?gca?cag?cgc?atg?atc?gat?gcc?tgc?gag?tcc?gca?ggg 451

Glu?Leu?Asp?Ser?Ala?Gln?Arg?Met?Ile?Asp?Ala?Cys?Glu?Ser?Ala?Gly

105 110 115

gtc?caa?ctt?ggc?gtg?ctc?ttc?cag?cgc?cgc?ttc?tgg?ccc?gcg?gct?caa 499

Val?Gln?Leu?Gly?Val?Leu?Phe?Gln?Arg?Arg?Phe?Trp?Pro?Ala?Ala?Gln

120 125 130

aaa?atg?aaa?aag?gag?ccg?tca?tgg?gcc?aat?gca?cgg?tagcgcttta 545

Lys?Met?Lys?Lys?Glu?Pro?Ser?Trp?Ala?Asn?Ala?Arg

135 140 145

ccgagagcat?tcc 558

<210>346

<211>145

<212>PRT

＜213〉Corynebacterium glutamicum

<400>346

Met?Ser?Asp?Lys?Ile?Trp?Lys?Val?Gly?Ile?Ile?Gly?Cys?Gly?Ala?Ile

1 5 10 15

Ser?Arg?Asn?His?Ile?Glu?Ala?Val?Gln?Ala?Ile?Pro?Gly?Ala?Glu?Val

20 25 30

Ser?Ala?Val?Cys?Asp?Val?Asp?Gly?Ala?Lys?Ala?Ser?Glu?Thr?Ala?Ala

35 40 45

Lys?Tyr?Gly?Ile?Ser?Pro?Ser?Phe?Thr?Ser?Val?Asp?Glu?Ile?Leu?Ala

50 55 60

Ser?Gly?Val?Asp?Ile?Val?Ala?Val?Cys?Thr?Pro?His?Pro?Thr?His?Glu

65 70 75 80

Thr?Val?Val?Leu?Ala?Ala?Ala?Ala?Ala?Gly?Val?His?Val?Leu?Cys?Glu

85 90 95

Lys?Pro?Ile?Ala?Ile?Glu?Leu?Asp?Ser?Ala?Gln?Arg?Met?lle?Asp?Ala

100 105 110

Cys?Glu?Ser?Ala?Gly?Val?Gln?Leu?Gly?Val?Leu?Phe?Gln?Arg?Arg?Phe

115 120 125

Trp?Pro?Ala?Ala?Gln?Lys?Met?Lys?Lys?Glu?Pro?Ser?Trp?Ala?Asn?Ala

130 135 140

Arg

145

<210>347

<211>1342

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1342)

<223>RXA00041

<400>347

atgaagcagc?agcatccaag?ctggaaaacg?ctgatcacta?ccgtctcatg?gagcaattaa?60

agctgcgcta?gaaacaaaaa?ggaaagtagt?gtgtggggct?atg?cac?aca?gaa?ctt 115

Met?His?Thr?Glu?Leu

1 5

tcc?agt?ttg?cgc?cct?gcg?tac?cat?gtg?act?cct?ccg?cag?ggc?agg?ctc 163

Ser?Ser?Leu?Arg?Pro?Ala?Tyr?His?Val?Thr?Pro?Pro?Gln?Gly?Arg?Leu

10 15 20

aat?gat?ccc?aac?gga?atg?tac?gtc?gat?ggc?gat?acc?ctc?cac?gtc?tac 211

Asn?Asp?Pro?Asn?Gly?Met?Tyr?Val?Asp?Gly?Asp?Thr?Leu?His?Val?Tyr

25 30 35

tac?cag?cac?gat?cca?ggt?ttc?ccc?ttc?gca?cca?aag?cgc?acc?ggc?tgg 259

Tyr?Gln?His?Asp?Pro?Gly?Phe?Pro?Phe?Ala?Pro?Lys?Arg?Thr?Gly?Trp

40 45 50

gct?cac?acc?acc?acg?ccg?ttg?acc?gga?ccg?cag?cga?ttg?cag?tgg?acg 307

Ala?His?Thr?Thr?Thr?Pro?Leu?Thr?Gly?Pro?Gln?Arg?Leu?Gln?Trp?Thr

55 60 65

cac?ctg?ccc?gac?gct?ctt?tac?ccg?gat?gca?tcc?tat?gac?ctg?gat?gga 355

His?Leu?Pro?Asp?Ala?Leu?Tyr?Pro?Asp?Ala?Ser?Tyr?Asp?Leu?Asp?Gly

70 75 80 85

tgc?tat?tcc?ggt?gga?gcc?gta?ttt?act?gac?ggc?aca?ctt?aaa?ctt?ttc 403

Cys?Tyr?Ser?Gly?Gly?Ala?Val?Phe?Thr?Asp?Gly?Thr?Leu?Lys?Leu?Phe

90 95 100

tac?acc?ggc?aac?cta?aaa?att?gac?ggc?aag?cgc?cgc?gcc?acc?caa?aac 451

Tyr?Thr?Gly?Asn?Leu?Lys?Ile?Asp?Gly?Lys?Arg?Arg?Ala?Thr?Gln?Asn

105 110 115

ctc?gtc?gaa?gtc?gag?gac?cca?act?ggg?ctg?atg?ggc?ggc?att?cat?cgc 499

Leu?Val?Glu?Val?Glu?Asp?Pro?Thr?Gly?Leu?Met?Gly?Gly?Ile?His?Arg

120 125 130

cgt?tcg?cct?aaa?aat?ccg?ctt?atc?gac?gga?ccc?gcc?agc?ggt?ttc?aca 547

Arg?Ser?Pro?Lys?Asn?Pro?Leu?Ile?Asp?Gly?Pro?Ala?Ser?Gly?Phe?Thr

135 140 145

ccc?cat?tac?cgc?gat?ccc?atg?atc?agc?cct?gat?ggt?gat?ggt?tgg?aaa 595

Pro?His?Tyr?Arg?Asp?Pro?Met?Ile?Ser?Pro?Asp?Gly?Asp?Gly?Trp?Lys

150 155 160 165

atg?gtt?ctt?ggg?gcc?caa?cgc?gaa?aac?ctc?acc?ggt?gca?gcg?gtt?cta 643

Met?Val?Leu?Gly?Ala?Gln?Arg?Glu?Asn?Leu?Thr?Gly?Ala?Ala?Val?Leu

170 175 180

tac?cgc?tcg?aca?gat?ctt?gaa?aac?tgg?gaa?ttc?tcc?ggt?gaa?atc?acc 691

Tyr?Arg?Ser?Thr?Asp?Leu?Glu?Asn?Trp?Glu?Phe?Ser?Gly?Glu?Ile?Thr

185 190 195

ttt?gac?ctc?agt?gat?gca?caa?cct?ggt?tct?gct?cct?gat?ctc?gtt?ccc 739

Phe?Asp?Leu?Ser?Asp?Ala?Gln?Pro?Gly?Ser?Ala?Pro?Asp?Leu?Val?Pro

200 205 210

ggt?ggc?tac?atg?tgg?gaa?tgc?ccc?aac?ctt?ttt?acg?ctt?cgc?gat?gaa 787

Gly?Gly?Tyr?Met?Trp?Glu?Cys?Pro?Asn?Leu?Phe?Thr?Leu?Arg?Asp?Glu

215 220 225

gaa?act?ggc?gaa?gat?ctc?gac?gtg?ctg?att?ttc?tgt?cca?caa?gga?ttg 835

Glu?Thr?Gly?Glu?Asp?Leu?Asp?Val?Leu?Ile?Phe?Cys?Pro?Gln?Gly?Leu

230 235 240 245

gac?cga?atc?cac?gat?gag?gtt?act?cac?tac?gca?agc?tct?gac?cag?tgc 883

Asp?Arg?Ile?His?Asp?Glu?Val?Thr?His?Tyr?Ala?Ser?Ser?Asp?Gln?Cys

250 255 260

gga?tat?gtc?gtc?ggc?aag?ctt?gaa?gga?acg?acc?ttc?cgc?gtc?ttg?cga 931

Gly?Tyr?Val?Val?Gly?Lys?Leu?Glu?Gly?Thr?Thr?Phe?Arg?Val?Leu?Arg

265 270 275

gga?ttc?agc?gag?ctg?gat?ttc?ggc?cat?gaa?ttc?tac?gca?ccg?cag?gtt 979

Gly?Phe?Ser?Glu?Leu?Asp?Phe?Gly?His?Glu?Phe?Tyr?Ala?Pro?Gln?Val

280 285 290

gca?gta?aac?ggt?tct?gat?gcc?tgg?ctc?gtg?ggc?tgg?atg?ggg?ctg?ccc 1027

Ala?Val?Asn?Gly?Ser?Asp?Ala?Trp?Leu?Val?Gly?Trp?Met?Gly?Leu?Pro

295 300 305

gcg?cag?gat?gat?cac?cca?aca?gtt?gca?cgg?gaa?gga?tgg?gtg?cac?tgc 1075

Ala?Gln?Asp?Asp?His?Pro?Thr?Val?Ala?Arg?Glu?Gly?Trp?Val?His?Cys

310 315 320 325

ctg?act?gtg?ccc?cgc?aag?ctt?cat?ttg?cgc?aac?cac?gcg?atc?tat?caa 1123

Leu?Thr?Val?Pro?Arg?Lys?Leu?His?Leu?Arg?Asn?His?Ala?Ile?Tyr?Gln

330 335 340

gag?ctt?ctt?ctc?cca?gag?ggg?gag?tca?ggg?gta?atc?aga?tct?gta?tta 1171

Glu?Leu?Leu?Leu?Pro?Glu?Gly?Glu?Ser?Gly?Val?Ile?Arg?Ser?Val?Leu

345 350 355

ggt?tct?gaa?cct?gtc?cga?gta?gac?atc?cga?ggc?aat?att?tcc?ctc?gag 1219

Gly?Ser?Glu?Pro?Val?Arg?Val?Asp?Ile?Arg?Gly?Asn?Ile?Ser?Leu?Glu

360 365 370

tgg?gat?ggt?gtc?cgt?ttg?tct?gtg?gat?cgt?ggt?ggt?gat?cgt?cgc?gta 1267

Trp?Asp?Gly?Val?Arg?Leu?Ser?Val?Asp?Arg?Gly?Gly?Asp?Arg?Arg?Val

375 380 385

gct?gag?gta?aaa?cct?ggc?gaa?tta?gtg?atc?gcg?gac?gat?aat?aca?gcc 1315

Ala?Glu?Val?Lys?Pro?Gly?Glu?Leu?Val?Ile?Ala?Asp?Asp?Asn?Thr?Ala

390 395 400 405

att?gag?ata?act?gca?ggt?gat?gga?cag 1342

Ile?Glu?Ile?Thr?Ala?Gly?Asp?Gly?Gln

410

<210>348

<211>414

<212>PRT

＜213〉Corynebacterium glutamicum

<400>348

Met?His?Thr?Glu?Leu?Ser?Ser?Leu?Arg?Pro?Ala?Tyr?His?Val?Thr?Pro

1 5 10 15

Pro?Gln?Gly?Arg?Leu?Asn?Asp?Pro?Asn?Gly?Met?Tyr?Val?Asp?Gly?Asp

20 25 30

Thr?Leu?His?Val?Tyr?Tyr?Gln?His?Asp?Pro?Gly?Phe?Pro?Phe?Ala?Pro

35 40 45

Lys?Arg?Thr?Gly?Trp?Ala?His?Thr?Thr?Thr?Pro?Leu?Thr?Gly?Pro?Gln

50 55 60

Arg?Leu?Gln?Trp?Thr?His?Leu?Pro?Asp?Ala?Leu?Tyr?Pro?Asp?Ala?Ser

65 70 75 80

Tyr?Asp?Leu?Asp?Gly?Cys?Tyr?Ser?Gly?Gly?Ala?Val?Phe?Thr?Asp?Gly

85 90 95

Thr?Leu?Lys?Leu?Phe?Tyr?Thr?Gly?Asn?Leu?Lys?Ile?Asp?Gly?Lys?Arg

100 105 110

Arg?Ala?Thr?Gln?Asn?Leu?Val?Glu?Val?Glu?Asp?Pro?Thr?Gly?Leu?Met

115 120 125

Gly?Gly?Ile?His?Arg?Arg?Ser?Pro?Lys?Asn?Pro?Leu?Ile?Asp?Gly?Pro

130 135 140

Ala?Ser?Gly?Phe?Thr?Pro?His?Tyr?Arg?Asp?Pro?Met?Ile?Ser?Pro?Asp

145 150 155 160

Gly?Asp?Gly?Trp?Lys?Met?Val?Leu?Gly?Ala?Gln?Arg?Glu?Asn?Leu?Thr

165 170 175

Gly?Ala?Ala?Val?Leu?Tyr?Arg?Ser?Thr?Asp?Leu?Glu?Asn?Trp?Glu?Phe

180 185 190

Ser?Gly?Glu?Ile?Thr?Phe?Asp?Leu?Ser?Asp?Ala?Gln?Pro?Gly?Ser?Ala

195 200 205

Pro?Asp?Leu?Val?Pro?Gly?Gly?Tyr?Met?Trp?Glu?Cys?Pro?Asn?Leu?Phe

210 215 220

Thr?Leu?Arg?Asp?Glu?Glu?Thr?Gly?Glu?Asp?Leu?Asp?Val?Leu?Ile?Phe

225 230 235 240

Cys?Pro?Gln?Gly?Leu?Asp?Arg?Ile?His?Asp?Glu?Val?Thr?His?Tyr?Ala

245 250 255

Ser?Ser?Asp?Gln?Cys?Gly?Tyr?Val?Val?Gly?Lys?Leu?Glu?Gly?Thr?Thr

260 265 270

Phe?Arg?Val?Leu?Arg?Gly?Phe?Ser?Glu?Leu?Asp?Phe?Gly?His?Glu?Phe

275 280 285

Tyr?Ala?Pro?Gln?Val?Ala?Val?Asn?Gly?Ser?Asp?Ala?Trp?Leu?Val?Gly

290 295 300

Trp?Met?Gly?Leu?Pro?Ala?Gln?Asp?Asp?His?Pro?Thr?Val?Ala?Arg?Glu

305 310 315 320

Gly?Trp?Val?His?Cys?Leu?Thr?Val?Pro?Arg?Lys?Leu?His?Leu?Arg?Asn

325 330 335

His?Ala?Ile?Tyr?Gln?Glu?Leu?Leu?Leu?Pro?Glu?Gly?Glu?Ser?Gly?Val

340 345 350

Ile?Arg?Ser?Val?Leu?Gly?Ser?Glu?Pro?Val?Arg?Val?Asp?Ile?Arg?Gly

355 360 365

Asn?Ile?Ser?Leu?Glu?Trp?Asp?Gly?Val?Arg?Leu?Ser?Val?Asp?Arg?Gly

370 375 380

Gly?Asp?Arg?Arg?Val?Ala?Glu?Val?Lys?Pro?Gly?Glu?Leu?Val?Ile?Ala

385 390 395 400

Asp?Asp?Asn?Thr?Ala?Ile?Glu?Ile?Thr?Ala?Gly?Asp?Gly?Gln

405 410

<210>349

<211>720

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<22l>CDS

<222>(1)..(720)

<223>RXA02026

<400>349

cca?ttt?cat?ata?caa?cca?gaa?aca?ggt?tta?tta?aat?gat?ccc?aac?gga 48

Pro?Phe?His?Ile?Gln?Pro?Glu?Thr?Gly?Leu?Leu?Asn?Asp?Pro?Asn?Gly

1 5 10 15

ctt?att?ttt?tat?aaa?ggg?aag?tat?tat?gtt?tca?cat?caa?tgg?ttc?cca 96

Leu?Ile?Phe?Tyr?Lys?Gly?Lys?Tyr?Tyr?Val?Ser?His?Gln?Trp?Phe?Pro

20 25 30

tta?ggc?gca?gta?cat?ggc?tta?aag?tat?tgg?tat?aac?tac?acg?agt?gat 144

Leu?Gly?Ala?Val?His?Gly?Leu?Lys?Tyr?Trp?Tyr?Asn?Tyr?Thr?Ser?Asp

35 40 45

gac?tta?ata?aac?ttt?aaa?cct?gaa?ggg?cca?ata?tta?aat?cca?gat?act 192

Asp?Leu?Ile?Asn?Phe?Lys?Pro?Glu?Gly?Pro?Ile?Leu?Asn?Pro?Asp?Thr

50 55 60

aaa?tat?gac?agc?cat?ggt?gtt?tat?agc?ggt?agc?gct?ttt?gaa?tat?aac 240

Lys?Tyr?Asp?Ser?His?Gly?Val?Tyr?Ser?Gly?Ser?Ala?Phe?Glu?Tyr?Asn

65 70 75 80

ggg?cat?tta?tat?tat?atg?tac?aca?gga?aat?cat?cga?gat?aat?cat?tgg 288

Gly?His?Leu?Tyr?Tyr?Met?Tyr?Thr?Gly?Asn?His?Arg?Asp?Asn?His?Trp

85 90 95

caa?cga?cat?gcg?agt?cag?atg?atc?gca?cga?ttg?aaa?gaa?gac?ggt?tca 336

Gln?Arg?His?Ala?Ser?Gln?Met?Ile?Ala?Arg?Leu?Lys?Glu?Asp?Gly?Ser

100 105 110

gtt?gaa?aag?ttt?cca?aag?cca?gta?att?agc?cag?caa?cca?gaa?gga?tat 384

Val?Glu?Lys?Phe?Pro?Lys?Pro?Val?Ile?Ser?Gln?Gln?Pro?Glu?Gly?Tyr

115 120 125

aca?agt?cat?ttt?aga?gat?cct?aaa?gtt?ttt?aaa?tat?ggt?gag?aaa?tat 432

Thr?Ser?His?Phe?Arg?Asp?Pro?Lys?Val?Phe?Lys?Tyr?Gly?Glu?Lys?Tyr

130 135 140

tat?gca?atc?att?ggc?gca?caa?aat?aat?gat?cag?caa?ggt?cga?tta?tta 480

Tyr?Ala?Ile?Ile?Gly?Ala?Gln?Asn?Asn?Asp?Gln?Gln?Gly?Arg?Leu?Leu

145 150 155 160

ctt?tat?aat?act?gaa?gat?ata?att?aat?tgg?cat?tat?tta?ggt?gaa?ata 528

Leu?Tyr?Asn?Thr?Glu?Asp?Ile?Ile?Asn?Trp?His?Tyr?Leu?Gly?Glu?Ile

165 170 175

aat?aca?gag?tta?gat?gat?ttt?gga?tat?atg?tgg?gaa?tgc?cca?gat?tac 576

Asn?Thr?Glu?Leu?Asp?Asp?Phe?Gly?Tyr?Met?Trp?Glu?Cys?Pro?Asp?Tyr

180 185 190

ttt?aat?tta?gat?aat?caa?gat?gtc?ata?ctt?att?tgt?cca?caa?ggt?att 624

Phe?Asn?Leu?Asp?Asn?Gln?Asp?Val?Ile?Leu?Ile?Cys?Pro?Gln?Gly?Ile

195 200 205

gaa?cca?aaa?ggc?aat?cag?ttc?aaa?aat?att?tat?caa?agt?ggt?tat?ata 672

Glu?Pro?Lys?Gly?Asn?Gln?Phe?Lys?Asn?Ile?Tyr?Gln?Ser?Gly?Tyr?Ile

210 215 220

ctt?gga?aag?ttt?gat?att?gaa?aag?tta?aca?tat?gaa?cat?gaa?aat?ttt 720

Leu?Gly?Lys?Phe?Asp?Ile?Glu?Lys?Leu?Thr?Tyr?Glu?His?Glu?Asn?Phe

225 230 235 240

<210>350

<211>240

<212>PRT

＜213〉Corynebacterium glutamicum

<400>350

Pro?Phe?His?Ile?Gln?Pro?Glu?Thr?Gly?Leu?Leu?Asn?Asp?Pro?Asn?Gly

1 5 10 15

Leu?Ile?Phe?Tyr?Lys?Gly?Lys?Tyr?Tyr?Val?Ser?His?Gln?Trp?Phe?Pro

20 25 30

Leu?Gly?Ala?Val?His?Gly?Leu?Lys?Tyr?Trp?Tyr?Asn?Tyr?Thr?Ser?Asp

35 40 45

Asp?Leu?Ile?Asn?Phe?Lys?Pro?Glu?Gly?Pro?Ile?Leu?Asn?Pro?Asp?Thr

50 55 60

Lys?Tyr?Asp?Ser?His?Gly?Val?Tyr?Ser?Gly?Ser?Ala?Phe?Glu?Tyr?Asn

65 70 75 80

Gly?His?Leu?Tyr?Tyr?Met?Tyr?Thr?Gly?Asn?His?Arg?Asp?Asn?His?Trp

85 90 95

Gln?Arg?His?Ala?Ser?Gln?Met?Ile?Ala?Arg?Leu?Lys?Glu?Asp?Gly?Ser

100 105 110

Val?Glu?Lys?Phe?Pro?Lys?Pro?Val?Ile?Ser?Gln?Gln?Pro?Glu?Gly?Tyr

115 120 125

Thr?Ser?His?Phe?Arg?Asp?Pro?Lys?Val?Phe?Lys?Tyr?Gly?Glu?Lys?Tyr

130 135 140

Tyr?Ala?Ile?Ile?Gly?Ala?Gln?Asn?Asn?Asp?Gln?Gln?Gly?Arg?Leu?Leu

145 150 155 160

Leu?Tyr?Asn?Thr?Glu?Asp?Ile?Ile?Asn?Trp?His?Tyr?Leu?Gly?Glu?Ile

165 170 175

Asn?Thr?Glu?Leu?Asp?Asp?Phe?Gly?Tyr?Met?Trp?Glu?Cys?Pro?Asp?Tyr

180 185 190

Phe?Asn?Leu?Asp?Asn?Gln?Asp?Val?Ile?Leu?Ile?Cys?Pro?Gln?Gly?Ile

195 200 205

Glu?Pro?Lys?Gly?Asn?Gln?Phe?Lys?Asn?Ile?Tyr?Gln?Ser?Gly?Tyr?Ile

210 215 220

Leu?Gly?Lys?Phe?Asp?Ile?Glu?Lys?Leu?Thr?Tyr?Glu?His?Glu?Asn?Phe

225 230 235 240

<210>351

<211>1617

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1594)

<223>RXA02061

<400>351

taacctgcct?tcacctggga?ttatccaccc?atgtgtgatg?aaatcgctac?cctgaatcaa?60

agacactggc?gtaattgagt?gaaggcagga?caataaagag?atg?acg?aac?gtt?tcc 115

Met?Thr?Asn?Val?Ser

1 5

ggg?tat?cac?cga?cca?gag?ctg?cac?atc?acc?gct?gaa?agt?ggt?gtt?ttg 163

Gly?Tyr?His?Arg?Pro?Glu?Leu?His?Ile?Thr?Ala?Glu?Ser?Gly?Val?Leu

10 15 20

ttt?gca?cct?gca?ggc?gtt?ctg?ttg?gat?gac?gac?acg?tgg?cat?ttc?ttc 211

Phe?Ala?Pro?Ala?Gly?Val?Leu?Leu?Asp?Asp?Asp?Thr?Trp?His?Phe?Phe

25 30 35

cac?cag?tac?cgt?ccc?tca?cca?gat?cac?ggc?ccc?agg?tgg?gcg?cac?caa 259

His?Gln?Tyr?Arg?Pro?Ser?Pro?Asp?His?Gly?Pro?Arg?Trp?Ala?His?Gln

40 45 50

ttc?gca?gag?cgc?act?cca?ttt?gtg?tgg?gat?atc?tgc?gat?gac?gtg?cta 307

Phe?Ala?Glu?Arg?Thr?Pro?Phe?Val?Trp?Asp?Ile?Cys?Asp?Asp?Val?Leu

55 60 65

gcc?cct?gaa?ggc?gat?gaa?acc?cag?gtt?cgc?gct?ggc?tca?gtg?gtg?tcc 355

Ala?Pro?Glu?Gly?Asp?Glu?Thr?Gln?Val?Arg?Ala?Gly?Ser?Val?Val?Ser

70 75 80 85

aac?aac?ggt?ggc?gtt?gat?ctg?tac?ttc?acc?tcg?gtt?gtt?ggc?ccc?act 403

Asn?Asn?Gly?Gly?Val?Asp?Leu?Tyr?Phe?Thr?Ser?Val?Val?Gly?Pro?Thr

90 95 100

tcc?act?atc?cag?ttg?gca?cac?atc?aac?aac?atc?cgt?ggc?acc?acc?gaa 451

Ser?Thr?Ile?Gln?Leu?Ala?His?Ile?Asn?Asn?Ile?Arg?Gly?Thr?Thr?Glu

105 110 115

ctg?atc?aat?gag?gac?gag?ctg?ggg?ctc?gat?cca?gat?gtc?tcc?cga?atc 499

Leu?Ile?Asn?Glu?Asp?Glu?Leu?Gly?Leu?Asp?Pro?Asp?Val?Ser?Arg?Ile

120 125 130

ggc?gaa?gtg?gtt?ggc?aac?act?gat?ggt?tat?gta?aag?ttc?cgc?tca?ccg 547

Gly?Glu?Val?Val?Gly?Asn?Thr?Asp?Gly?Tyr?Val?Lys?Phe?Arg?Ser?Pro

135 140 145

tgc?gtt?atc?cca?ggt?tgg?gaa?gac?caa?gga?aac?cgc?gat?gaa?ggc?cac 595

Cys?Val?Ile?Pro?Gly?Trp?Glu?Asp?Gln?Gly?Asn?Arg?Asp?Glu?Gly?His

150 155 160 165

tca?gga?tgg?ttg?atg?ctc?gca?gtt?act?ggc?cca?gtt?gaa?gcc?cca?aca 643

Ser?Gly?Trp?Leu?Met?Leu?Ala?Val?Thr?Gly?Pro?Val?Glu?Ala?Pro?Thr

170 175 180

gta?gtg?gtc?ctc?gac?tcg?cca?gat?gga?aga?gaa?tgg?tcc?att?aca?ggt 691

Val?Val?Val?Leu?Asp?Ser?Pro?Asp?Gly?Arg?Glu?Trp?Ser?Ile?Thr?Gly

185 190 195

ccc?ctg?tct?ctc?aac?ggc?ctc?tct?gga?tta?gag?tca?gac?gaa?gtt?cta 739

Pro?Leu?Ser?Leu?Asn?Gly?Leu?Ser?Gly?Leu?Glu?Ser?Asp?Glu?Val?Leu

200 205 210

gtt?gct?cct?cgc?atg?att?cgt?ctg?cgc?gat?gaa?gtg?gat?cat?gaa?atc 787

Val?Ala?Pro?Arg?Met?Ile?Arg?Leu?Arg?Asp?Glu?Val?Asp?His?Glu?Ile

215 220 225

tac?gat?gtc?ctc?att?gtc?acc?att?gaa?caa?gac?ggg?att?gac?att?tcg 835

Tyr?Asp?Val?Leu?Ile?Val?Thr?Ile?Glu?Gln?Asp?Gly?Ile?Asp?Ile?Ser

230 235 240 245

gga?tac?ctg?gta?ggc?cag?ctc?aac?ggc?tca?gaa?ttc?gat?gtg?aag?act 883

Gly?Tyr?Leu?Val?Gly?Gln?Leu?Asn?Gly?Ser?Glu?Phe?Asp?Val?Lys?Thr

250 255 260

cca?ttt?acc?cgc?atc?gat?ttt?ggc?cat?gat?ttc?tct?cgc?ccc?cgc?aac 931

Pro?Phe?Thr?Arg?Ile?Asp?Phe?Gly?His?Asp?Phe?Ser?Arg?Pro?Arg?Asn

265 270 275

acc?aac?tac?gcc?gaa?acc?acc?atc?ggc?tac?gac?ttc?gcc?cac?atc?ttt 979

Thr?Asn?Tyr?Ala?Glu?Thr?Thr?Ile?Gly?Tyr?Asp?Phe?Ala?His?Ile?Phe

280 285 290

ggt?ctc?atg?aat?ggc?gta?ggt?cgt?ttg?gac?tcc?ccc?act?gag?cat?ctc 1027

Gly?Leu?Met?Asn?Gly?Val?Gly?Arg?Leu?Asp?Ser?Pro?Thr?Glu?His?Leu

295 300 305

agt?tgg?aag?gaa?gaa?ggc?tgg?gca?aac?gct?att?tct?ttc?cca?cgt?att 1075

Ser?Trp?Lys?Glu?Glu?Gly?Trp?Ala?Asn?Ala?Ile?Ser?Phe?Pro?Arg?Ile

310 315 320 325

gtc?acg?ctc?cag?gac?ggt?acg?gtc?ttc?cag?acc?cct?cca?gaa?gga?ttg 1123

Val?Thr?Leu?Gln?Asp?Gly?Thr?Val?Phe?Gln?Thr?Pro?Pro?Glu?Gly?Leu

330 335 340

ctt?gat?gcc?att?cat?gaa?tcc?gag?gca?gcg?gca?ggt?tgg?acc?gga?ctg 1171

Leu?Asp?Ala?Ile?His?Glu?Ser?Glu?Ala?Ala?Ala?Gly?Trp?Thr?Gly?Leu

345 350 355

tgc?gaa?atc?cca?tca?aac?agc?gca?gtt?gaa?gtg?gcg?ttg?aag?gac?caa 1219

Cys?Glu?Ile?Pro?Ser?Asn?Ser?Ala?Val?Glu?Val?Ala?Leu?Lys?Asp?Gln

360 365 370

gaa?ggt?gaa?atc?gct?gca?aca?atc?act?cac?cgc?cac?aat?cag?cta?gtc 1267

Glu?Gly?Glu?Ile?Ala?Ala?Thr?Ile?Thr?His?Arg?His?Asn?Gln?Leu?Val

375 380 385

gtt?gat?cgg?tcc?atg?aac?ccc?aac?cac?gcg?ggt?gat?cca?cac?gcg?att 1315

Val?Asp?Arg?Ser?Met?Asn?Pro?Asn?His?Ala?Gly?Asp?Pro?His?Ala?Ile

390 395 400 405

gca?cca?ttg?act?gat?gat?gaa?aca?gat?tca?ctg?ttc?att?gtc?gtt?gac 1363

Ala?Pro?Leu?Thr?Asp?Asp?Glu?Thr?Asp?Ser?Leu?Phe?Ile?Val?Val?Asp

410 415 420

ggc?tct?aca?gta?gaa?gtt?ttt?gct?gat?ggc?ggt?tat?gta?tca?atg?gca 1411

Gly?Ser?Thr?Val?Glu?Val?Phe?Ala?Asp?Gly?Gly?Tyr?Val?Ser?Met?Ala

425 430 435

agc?cgt?gtg?tat?ttc?aac?aac?gga?cca?ttc?agc?gaa?ttt?gag?gtc?acc 1459

Ser?Arg?Val?Tyr?Phe?Asn?Asn?Gly?Pro?Phe?Ser?Glu?Phe?Glu?Val?Thr

440 445 450

acc?acc?ggt?gac?gca?agc?att?att?cgc?cag?gaa?agt?cac?ttc?cct?gtt 1507

Thr?Thr?Gly?Asp?Ala?Ser?Ile?Ile?Arg?Gln?Glu?Ser?His?Phe?Pro?Val

455 460 465

gat?ttc?agt?tcg?gtg?tcc?cta?gat?ata?gat?gat?ctc?act?gcg?ctc?atg 1555

Asp?Phe?Ser?Ser?Val?Ser?Leu?Asp?Ile?Asp?Asp?Leu?Thr?Ala?Leu?Met

470 475 480 485

cag?ttc?gat?gaa?aac?gaa?ccg?cat?gaa?ggc?cca?gtg?aga?taagagttag 1604

Gln?Phe?Asp?Glu?Asn?Glu?Pro?His?Glu?Gly?Pro?Val?Arg

490 495

atgcgttcca?gcc 1617

<210>352

<211>498

<212>PRT

＜213〉Corynebacterium glutamicum

<400>352

Met?Thr?Asn?Val?Ser?Gly?Tyr?His?Arg?Pro?Glu?Leu?His?Ile?Thr?Ala

1 5 10 15

Glu?Ser?Gly?Val?Leu?Phe?Ala?Pro?Ala?Gly?Val?Leu?Leu?Asp?Asp?Asp

20 25 30

Thr?Trp?His?Phe?Phe?His?Gln?Tyr?Arg?Pro?Ser?Pro?Asp?His?Gly?Pro

35 40 45

Arg?Trp?Ala?His?Gln?Phe?Ala?Glu?Arg?Thr?Pro?Phe?Val?Trp?Asp?Ile

50 55 60

Cys?Asp?Asp?Val?Leu?Ala?Pro?Glu?Gly?Asp?Glu?Thr?Gln?Val?Arg?Ala

65 70 75 80

Gly?Ser?Val?Val?Ser?Asn?Asn?Gly?Gly?Val?Asp?Leu?Tyr?Phe?Thr?Ser

85 90 95

Val?Val?Gly?Pro?Thr?Ser?Thr?Ile?Gln?Leu?Ala?His?Ile?Asn?Asn?Ile

100 105 110

Arg?Gly?Thr?Thr?Glu?Leu?Ile?Asn?Glu?Asp?Glu?Leu?Gly?Leu?Asp?Pro

115 120 125

Asp?Val?Ser?Arg?Ile?Gly?Glu?Val?Val?Gly?Asn?Thr?Asp?Gly?Tyr?Val

130 135 140

Lys?Phe?Arg?Ser?Pro?Cys?Val?Ile?Pro?Gly?Trp?Glu?Asp?Gln?Gly?Asn

145 150 155 160

Arg?Asp?Glu?Gly?His?Ser?Gly?Trp?Leu?Met?Leu?Ala?Val?Thr?Gly?Pro

165 170 175

Val?Glu?Ala?Pro?Thr?Val?Val?Val?Leu?Asp?Ser?Pro?Asp?Gly?Arg?Glu

180 185 190

Trp?Ser?Ile?Thr?Gly?Pro?Leu?Ser?Leu?Asn?Gly?Leu?Ser?Gly?Leu?Glu

195 200 205

Ser?Asp?Glu?Val?Leu?Val?Ala?Pro?Arg?Met?Ile?Arg?Leu?Arg?Asp?Glu

210 215 220

Val?Asp?His?Glu?Ile?Tyr?Asp?Val?Leu?Ile?Val?Thr?Ile?Glu?Gln?Asp

225 230 235 240

Gly?Ile?Asp?Ile?Ser?Gly?Tyr?Leu?Val?Gly?Gln?Leu?Asn?Gly?Ser?Glu

245 250 255

Phe?Asp?Val?Lys?Thr?Pro?Phe?Thr?Arg?Ile?Asp?Phe?Gly?His?Asp?Phe

260 265 270

Ser?Arg?Pro?Arg?Asn?Thr?Asn?Tyr?Ala?Glu?Thr?Thr?Ile?Gly?Tyr?Asp

275 280 285

Phe?Ala?His?Ile?Phe?Gly?Leu?Met?Asn?Gly?Val?Gly?Arg?Leu?Asp?Ser

290 295 300

Pro?Thr?Glu?His?Leu?Ser?Trp?Lys?Glu?Glu?Gly?Trp?Ala?Asn?Ala?Ile

305 310 315 320

Ser?Phe?Pro?Arg?Ile?Val?Thr?Leu?Gln?Asp?Gly?Thr?Val?Phe?Gln?Thr

325 330 335

Pro?Pro?Glu?Gly?Leu?Leu?Asp?Ala?Ile?His?Glu?Ser?Glu?Ala?Ala?Ala

340 345 350

Gly?Trp?Thr?Gly?Leu?Cys?Glu?Ile?Pro?Ser?Asn?Ser?Ala?Val?Glu?Val

355 360 365

Ala?Leu?Lys?Asp?Gln?Glu?Gly?Glu?Ile?Ala?Ala?Thr?Ile?Thr?His?Arg

370 375 380

His?Asn?Gln?Leu?Val?Val?Asp?Arg?Ser?Met?Asn?Pro?Asn?His?Ala?Gly

385 390 395 400

Asp?Pro?His?Ala?Ile?Ala?Pro?Leu?Thr?Asp?Asp?Glu?Thr?Asp?Ser?Leu

405 410 415

Phe?Ile?Val?Val?Asp?Gly?Ser?Thr?Val?Glu?Val?Phe?Ala?Asp?Gly?Gly

420 425 430

Tyr?Val?Ser?Met?Ala?Ser?Arg?Val?Tyr?Phe?Asn?Asn?Gly?Pro?Phe?Ser

435 440 445

Glu?Phe?Glu?Val?Thr?Thr?Thr?Gly?Asp?Ala?Ser?Ile?Ile?Arg?Gln?Glu

450 455 460

Ser?His?Phe?Pro?Val?Asp?Phe?Ser?Ser?Val?Ser?Leu?Asp?Ile?Asp?Asp

465 470 475 480

Leu?Thr?Ala?Leu?Met?Gln?Phe?Asp?Glu?Asn?Glu?Pro?His?Glu?Gly?Pro

485 490 495

Val?Arg

<210>353

<211>1305

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1282)

<223>RXN01369

<400>353

ctgcgacgga?cctagcaaag?gggcgctgac?acaagcactg?cgtttgctgg?tgcgcggaca?60

gtcagccacg?acctattcca?ttgaagaaaa?ggacttgtaa?atg?gag?cta?ttg?gaa 115

Met?Glu?Leu?Leu?Glu

1 5

ggc?tca?ctg?cgc?acc?tac?cca?tgg?ggt?tca?aga?aca?ctg?atc?gct?gat 163

Gly?Ser?Leu?Arg?Thr?Tyr?Pro?Trp?Gly?Ser?Arg?Thr?Leu?Ile?Ala?Asp

10 15 20

ctc?aaa?ggc?gaa?gaa?tca?cca?tcg?tct?cgc?cca?gag?gcc?gaa?gtc?tgg 211

Leu?Lys?Gly?Glu?Glu?Ser?Pro?Ser?Ser?Arg?Pro?Glu?Ala?Glu?Val?Trp

25 30 35

ttc?ggt?gcc?cac?cca?gga?tca?cca?tca?acc?atc?ggt?gga?aac?gca?ctc 259

Phe?Gly?Ala?His?Pro?Gly?Ser?Pro?Ser?Thr?Ile?Gly?Gly?Asn?Ala?Leu

40 45 50

aac?gaa?gtc?atc?gca?gcg?aac?ccc?gaa?gaa?gca?ttg?ggc?acg?cgt?gtt 307

Asn?Glu?Val?Ile?Ala?Ala?Asn?Pro?Glu?Glu?Ala?Leu?Gly?Thr?Arg?Val

55 60 65

gcc?gaa?gcg?ttt?gaa?aat?gag?ctt?cca?ttc?ctc?ctc?aaa?atc?ctc?gca 355

Ala?Glu?Ala?Phe?Glu?Asn?Glu?Leu?Pro?Phe?Leu?Leu?Lys?Ile?Leu?Ala

70 75 80 85

gcg?gga?gca?ccc?cta?tca?ctg?cag?gcc?cac?cca?tcg?ctg?gaa?cag?gcc 403

Ala?Gly?Ala?Pro?Leu?Ser?Leu?Gln?Ala?His?Pro?Ser?Leu?Glu?Gln?Ala

90 95 100

cgt?gaa?gga?ttc?gcc?cgc?gaa?aac?tca?gca?gga?att?gac?ctc?ggc?gca 451

Arg?Glu?Gly?Phe?Ala?Arg?Glu?Asn?Ser?Ala?Gly?Ile?Asp?Leu?Gly?Ala

105 110 115

ccg?aac?cgc?aac?tac?cgc?gac?cca?aac?cac?aag?cca?gag?ctg?atc?gtt 499

Pro?Asn?Arg?Asn?Tyr?Arg?Asp?Pro?Asn?His?Lys?Pro?Glu?Leu?Ile?Val

120 125 130

gct?ctc?acg?gaa?ttc?atc?gcg?atg?gca?ggc?ttc?cgc?cca?ctg?cgg?aac 547

Ala?Leu?Thr?Glu?Phe?Ile?Ala?Met?Ala?Gly?Phe?Arg?Pro?Leu?Arg?Asn

135 140 145

acc?ctc?acc?att?ttc?gac?gcc?ctc?gcc?tgc?gaa?ccc?ctc?gac?cgc?tac 595

Thr?Leu?Thr?Ile?Phe?Asp?Ala?Leu?Ala?Cys?Glu?Pro?Leu?Asp?Arg?Tyr

150 155 160 165

cgc?agc?atg?ctc?acc?gtc?gac?aac?gag?gaa?gaa?tcc?ctc?cgc?gca?ctg 643

Arg?Ser?Met?Leu?Thr?Val?Asp?Asn?Glu?Glu?Glu?Ser?Leu?Arg?Ala?Leu

170 175 180

ttt?acc?acc?tgg?atc?acc?atc?ccc?atc?ggt?aaa?cga?cac?gaa?ctc?atc 691

Phe?Thr?Thr?Trp?Ile?Thr?Ile?Pro?Ile?Gly?Lys?Arg?His?Glu?Leu?Ile

185 190 195

gat?gcc?ctc?atc?agc?aac?gcc?cac?acc?tac?ctt?gag?gca?agc?gat?cgt 739

Asp?Ala?Leu?Ile?Ser?Asn?Ala?His?Thr?Tyr?Leu?Glu?Ala?Ser?Asp?Arg

200 205 210

gac?gag?gac?atc?gca?ttc?gtg?ctc?tca?cac?atc?atc?gag?ctc?aac?gaa 787

Asp?Glu?Asp?Ile?Ala?Phe?Val?Leu?Ser?His?Ile?Ile?Glu?Leu?Asn?Glu

215 220 225

cag?tac?ccc?ggc?gat?gtc?ggc?gtt?ctg?ggt?gct?ctg?ctg?ttg?aac?ttc 835

Gln?Tyr?Pro?Gly?Asp?Val?Gly?Val?Leu?Gly?Ala?Leu?Leu?Leu?Asn?Phe

230 235 240 245

tac?aaa?ctt?gcc?cca?ggc?gaa?gcc?ctc?tac?ctc?gac?gcc?gca?aac?ctt 883

Tyr?Lys?Leu?Ala?Pro?Gly?Glu?Ala?Leu?Tyr?Leu?Asp?Ala?Ala?Asn?Leu

250 255 260

cac?gca?tac?atc?agc?ggc?ctc?ggc?gta?gag?atc?atg?gcg?aac?tcc?gac 931

His?Ala?Tyr?Ile?Ser?Gly?Leu?Gly?Val?Glu?Ile?Met?Ala?Asn?Ser?Asp

265 270 275

aac?gtg?ctc?cgc?ggt?gga?ctg?aca?tcc?aaa?tac?gtc?gac?gtc?ccg?gag 979

Asn?Val?Leu?Arg?Gly?Gly?Leu?Thr?Ser?Lys?Tyr?Val?Asp?Val?Pro?Glu

280 285 290

ctt?gtg?cgc?gtg?ttg?gat?ttc?aac?tct?ttg?gaa?aac?gct?cgc?gtg?gac 1027

Leu?Val?Arg?Val?Leu?Asp?Phe?Asn?Ser?Leu?Glu?Asn?Ala?Arg?Val?Asp

295 300 305

gtt?gaa?gaa?gac?ggt?gca?acg?acc?cac?tac?cca?gtt?cca?atc?aac?gaa 1075

Val?Glu?Glu?Asp?Gly?Ala?Thr?Thr?His?Tyr?Pro?Val?Pro?Ile?Asn?Glu

310 315 320 325

ttc?caa?ctc?gat?cgc?gtt?gca?gtt?cag?ggc?gaa?gca?gaa?gcc?aac?cac 1123

Phe?Gln?Leu?Asp?Arg?Val?Ala?Val?Gln?Gly?Glu?Ala?Glu?Ala?Asn?His

330 335 340

gat?ggt?ccc?atg?att?gtt?ctg?tgc?acc?tcc?gga?act?gtt?tcc?ttg?gaa 1171

Asp?Gly?Pro?Met?Ile?Val?Leu?Cys?Thr?Ser?Gly?Thr?Val?Ser?Leu?Glu

345 350 355

gca?ggg?gag?aag?acc?ctc?gaa?gta?gca?gca?ggt?cac?gcc?gca?tgg?gtt 1219

Ala?Gly?Glu?Lys?Thr?Leu?Glu?Val?Ala?Ala?Gly?His?Ala?Ala?Trp?Val

360 365 370

cca?gca?aac?gac?cca?acc?att?gcg?atg?cgt?tct?gag?gac?gca?gaa?gta 1267

Pro?Ala?Asn?Asp?Pro?Thr?Ile?Ala?Met?Arg?Ser?Glu?Asp?Ala?Glu?Val

375 380 385

ttc?ctc?gct?agg?gtt?tagatctttt?tagattaaaa?tca 1305

Phe?Leu?Ala?Arg?Val

390

<210>354

<211>394

<212>PRT

＜213〉Corynebacterium glutamicum

<400>354

Met?Glu?Leu?Leu?Glu?Gly?Ser?Leu?Arg?Thr?Tyr?Pro?Trp?Gly?Ser?Arg

1 5 10 15

Thr?Leu?Ile?Ala?Asp?Leu?Lys?Gly?Glu?Glu?Ser?Pro?Ser?Ser?Arg?Pro

20 25 30

Glu?Ala?Glu?Val?Trp?Phe?Gly?Ala?His?Pro?Gly?Ser?Pro?Ser?Thr?Ile

35 40 45

Gly?Gly?Asn?Ala?Leu?Asn?Glu?Val?Ile?Ala?Ala?Asn?Pro?Glu?Glu?Ala

50 55 60

Leu?Gly?Thr?Arg?Val?Ala?Glu?Ala?Phe?Glu?Asn?Glu?Leu?Pro?Phe?Leu

65 70 75 80

Leu?Lys?Ile?Leu?Ala?Ala?Gly?Ala?Pro?Leu?Ser?Leu?Gln?Ala?His?Pro

85 90 95

Ser?Leu?Glu?Gln?Ala?Arg?Glu?Gly?Phe?Ala?Arg?Glu?Asn?Ser?Ala?Gly

100 105 110

Ile?Asp?Leu?Gly?Ala?Pro?Asn?Arg?Asn?Tyr?Arg?Asp?Pro?Asn?His?Lys

115 120 125

Pro?Glu?Leu?Ile?Val?Ala?Leu?Thr?Glu?Phe?Ile?Ala?Met?Ala?Gly?Phe

130 135 140

Arg?Pro?Leu?Arg?Asn?Thr?Leu?Thr?Ile?Phe?Asp?Ala?Leu?Ala?Cys?Glu

145 150 155 160

Pro?Leu?Asp?Arg?Tyr?Arg?Ser?Met?Leu?Thr?Val?Asp?Asn?Glu?Glu?Glu

165 170 175

Ser?Leu?Arg?Ala?Leu?Phe?Thr?Thr?Trp?Ile?Thr?Ile?Pro?Ile?Gly?Lys

180 185 190

Arg?His?Glu?Leu?Ile?Asp?Ala?Leu?Ile?Ser?Asn?Ala?His?Thr?Tyr?Leu

195 200 205

Glu?Ala?Ser?Asp?Arg?Asp?Glu?Asp?Ile?Ala?Phe?Val?Leu?Ser?His?Ile

210 215 220

Ile?Glu?Leu?Asn?Glu?Gln?Tyr?Pro?Gly?Asp?Val?Gly?Val?Leu?Gly?Ala

225 230 235 240

Leu?Leu?Leu?Asn?Phe?Tyr?Lys?Leu?Ala?Pro?Gly?Glu?Ala?Leu?Tyr?Leu

245 250 255

Asp?Ala?Ala?Asn?Leu?His?Ala?Tyr?Ile?Ser?Gly?Leu?Gly?Val?Glu?Ile

260 265 270

Met?Ala?Asn?Ser?Asp?Asn?Val?Leu?Arg?Gly?Gly?Leu?Thr?Ser?Lys?Tyr

275 280 285

Val?Asp?Val?Pro?Glu?Leu?Val?Arg?Val?Leu?Asp?Phe?Asn?Ser?Leu?Glu

290 295 300

Asn?Ala?Arg?Val?Asp?Val?Glu?Glu?Asp?Gly?Ala?Thr?Thr?His?Tyr?Pro

305 310 315 320

Val?Pro?Ile?Asn?Glu?Phe?Gln?Leu?Asp?Arg?Val?Ala?Val?Gln?Gly?Glu

325 330 335

Ala?Glu?Ala?Asn?His?Asp?Gly?Pro?Met?Ile?Val?Leu?Cys?Thr?Ser?Gly

340 345 350

Thr?Val?Ser?Leu?Glu?Ala?Gly?Glu?Lys?Thr?Leu?Glu?Val?Ala?Ala?Gly

355 360 365

His?Ala?Ala?Trp?Val?Pro?Ala?Asn?Asp?Pro?Thr?Ile?Ala?Met?Arg?Ser

370 375 380

Glu?Asp?Ala?Glu?Val?Phe?Leu?Ala?Arg?Val

385 390

<210>355

<211>524

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(501)

<223>FRXA01369

<400>355

aac?gaa?cag?tgc?ctc?ggc?gat?gtc?ggc?gtt?ctg?ggt?gct?ctg?ctg?ttg 48

Asn?Glu?Gln?Gys?Leu?Gly?Asp?Val?Gly?Val?Leu?Gly?Ala?Leu?Leu?Leu

1 5 10 15

aac?ttc?tac?aaa?ctt?gcc?cca?ggc?gaa?gcc?ctc?tac?ctc?gac?gcc?gca 96

Asn?Phe?Tyr?Lys?Leu?Ala?Pro?Gly?Glu?Ala?Leu?Tyr?Leu?Asp?Ala?Ala

20 25 30

aac?ctt?cac?gca?tac?atc?agc?ggc?ctc?ggc?gta?gag?atc?atg?gcg?aac 144

Asn?Leu?His?Ala?Tyr?Ile?Ser?Gly?Leu?Gly?Val?Glu?Ile?Met?Ala?Asn

35 40 45

tcc?gac?aac?gtg?ctc?cgc?ggt?gga?ctg?aca?tcc?aaa?tac?gtc?gac?gtc 192

Ser?Asp?Asn?Val?Leu?Arg?Gly?Gly?Leu?Thr?Ser?Lys?Tyr?Val?Asp?Val

50 55 60

ccg?gag?ctt?gtg?cgc?gtg?ttg?gat?ttc?aac?tct?ttg?gaa?aac?gct?cgc 240

Pro?Glu?Leu?Val?Arg?Val?Leu?Asp?Phe?Asn?Ser?Leu?Glu?Asn?Ala?Arg

65 70 75 80

gtg?gac?gtt?gaa?gaa?gac?ggt?gca?acg?acc?cac?tac?cca?gtt?cea?atc 288

Val?Asp?Val?Glu?Glu?Asp?Gly?Ala?Thr?Thr?His?Tyr?Pro?Val?Pro?Ile

85 90 95

aac?gaa?ttc?caa?ctc?gat?cgc?gtt?gca?gtt?cag?ggc?gaa?gca?gaa?gcc 336

Asn?Glu?Phe?Gln?Leu?Asp?Arg?Val?Ala?Val?Gln?Gly?Glu?Ala?Glu?Ala

100 105 110

aac?cac?gat?ggt?ccc?atg?att?gtt?ctg?tgc?acc?tcc?gga?act?gtt?tcc 384

Asn?His?Asp?Gly?Pro?Met?Ile?Val?Leu?Cys?Thr?Ser?Gly?Thr?Val?Ser

115 120 125

ttg?gaa?gca?ggg?gag?aag?acc?ctc?gaa?gta?gca?gca?ggt?cac?gcc?gca 432

Leu?Glu?Ala?Gly?Glu?Lys?Thr?Leu?Glu?Val?Ala?Ala?Gly?His?Ala?Ala

130 135 140

tgg?gtt?cca?gca?aac?gac?cca?acc?att?gcg?atg?cgt?tct?gag?gac?gca 480

Trp?Val?Pro?Ala?Asn?Asp?Pro?Thr?Ile?Ala?Met?Arg?Ser?Glu?Asp?Ala

145 150 155 160

gaa?gta?ttc?ctc?gct?agg?gtt?tagatctttt?tagattaaaa?tca 524

Glu?Val?Phe?Leu?Ala?Arg?Val

165

<210>356

<211>167

<212>PRT

＜213〉Corynebacterium glutamicum

<400>356

Asn?Glu?Gln?Cys?Leu?Gly?Asp?Val?Gly?Val?Leu?Gly?Ala?Leu?Leu?Leu

1 5 10 15

Asn?Phe?Tyr?Lys?Leu?Ala?Pro?Gly?Glu?Ala?Leu?Tyr?Leu?Asp?Ala?Ala

20 25 30

Asn?Leu?His?Ala?Tyr?Ile?Ser?Gly?Leu?Gly?Val?Glu?Ile?Met?Ala?Asn

35 40 45

Ser?Asp?Asn?Val?Leu?Arg?Gly?Gly?Leu?Thr?Ser?Lys?Tyr?Val?Asp?Val

50 55 60

Pro?Glu?Leu?Val?Arg?Val?Leu?Asp?Phe?Asn?Ser?Leu?Glu?Asn?Ala?Arg

65 70 75 80

Val?Asp?Val?Glu?Glu?Asp?Gly?Ala?Thr?Thr?His?Tyr?Pro?Val?Pro?Ile

85 90 95

Asn?Glu?Phe?Gln?Leu?Asp?Arg?Val?Ala?Val?Gln?Gly?Glu?Ala?Glu?Ala

100 105 110

Asn?His?Asp?Gly?Pro?Met?Ile?Val?Leu?Cys?Thr?Ser?Gly?Thr?Val?Ser

115 120 125

Leu?Glu?Ala?Gly?Glu?Lys?Thr?Leu?Glu?Val?Ala?Ala?Gly?His?Ala?Ala

130 135 140

Trp?Val?Pro?Ala?Asn?Asp?Pro?Thr?Ile?Ala?Met?Arg?Ser?Glu?Asp?Ala

145 150 155 160

Glu?Val?Phe?Leu?Ala?Arg?Val

165

<210>357

<211>808

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(808)

<223>FRXA01373

<400>357

ctgcgacgga?cctagcaaag?gggcgctgac?acaagcactg?cgtttgctgg?tgcgcggaca?60

gtcagccacg?acctattcca?ttgaagaaaa?ggacttgtaa?atg?gag?cta?ttg?gaa 115

Met?Glu?Leu?Leu?Glu

1 5

ggc?tca?ctg?cgc?acc?tac?cca?tgg?ggt?tca?aga?aca?ctg?atc?gct?gat 163

Gly?Ser?Leu?Arg?Thr?Tyr?Pro?Trp?Gly?Ser?Arg?Thr?Leu?Ile?Ala?Asp

10 15 20

ctc?aaa?ggc?gaa?gaa?tca?cca?tcg?tct?cgc?cca?gag?gcc?gaa?gtc?tgg 211

Leu?Lys?Gly?Glu?Glu?Ser?Pro?Ser?Ser?Arg?Pro?Glu?Ala?Glu?Val?Trp

25 30 35

ttc?ggt?gcc?cac?cca?gga?tca?cca?tca?acc?atc?ggt?gga?aac?gca?ctc 259

Phe?Gly?Ala?His?Pro?Gly?Ser?Pro?Ser?Thr?Ile?Gly?Gly?Asn?Ala?Leu

40 45 50

aac?gaa?gtc?atc?gca?gcg?aac?ccc?gaa?gaa?gca?ttg?ggc?acg?cgt?gtt 307

Asn?Glu?Val?Ile?Ala?Ala?Asn?Pro?Glu?Glu?Ala?Leu?Gly?Thr?Arg?Val

55 60 65

gcc?gaa?gcg?ttt?gaa?aat?gag?ctt?cca?ttc?ctc?ctc?aaa?atc?ctc?gca 355

Ala?Glu?Ala?Phe?Glu?Asn?Glu?Leu?Pro?Phe?Leu?Leu?Lys?Ile?Leu?Ala

70 75 80 85

gcg?gga?gca?ccc?cta?tca?ctg?cag?gcc?cac?cca?tcg?ctg?gaa?cag?gcc 403

Ala?Gly?Ala?Pro?Leu?Ser?Leu?Gln?Ala?His?Pro?Ser?Leu?Glu?Gln?Ala

90 95 100

cgt?gaa?gga?ttc?gcc?cgc?gaa?aac?tca?gca?gga?att?gac?ctc?ggc?gca 451

Arg?Glu?Gly?Phe?Ala?Arg?Glu?Ash?Ser?Ala?Gly?Ile?Asp?Leu?Gly?Ala

105 110 115

ccg?aac?cgc?aac?tac?cgc?gac?cca?aac?cac?aag?cca?gag?ctg?atc?gtt 499

Pro?Asn?Arg?Asn?Tyr?Arg?Asp?Pro?Asn?His?Lys?Pro?Glu?Leu?Ile?Val

120 125 130

gct?ctc?acg?gaa?ttc?atc?gcg?atg?gca?ggc?ttc?cgc?cca?ctg?cgg?aac 547

Ala?Leu?Thr?Glu?Phe?Ile?Ala?Met?Ala?Gly?Phe?Arg?Pro?Leu?Arg?Asn

135 140 145

acc?ctc?acc?att?ttc?gac?gcc?ctc?gcc?tgc?gaa?ccc?ctc?gac?cgc?tac 595

Thr?Leu?Thr?Ile?Phe?Asp?Ala?Leu?Ala?Cys?Glu?Pro?Leu?Asp?Arg?Tyr

150 155 160 165

cgc?agc?atg?ctc?acc?gtc?gac?aac?gag?gaa?gaa?tcc?ctc?cgc?gca?ctg 643

Arg?Ser?Met?Leu?Thr?Val?Asp?Asn?Glu?Glu?Glu?Ser?Leu?Arg?Ala?Leu

170 175 180

ttt?acc?acc?tgg?atc?acc?atc?ccc?atc?ggt?aaa?cga?cac?gaa?ctc?atc 691

Phe?Thr?Thr?Trp?Ile?Thr?Ile?Pro?Ile?Gly?Lys?Arg?His?Glu?Leu?Ile

185 190 195

gat?gcc?ctc?atc?agc?aac?gcc?cac?acc?tac?ctt?gag?gca?agc?gat?cgt 739

Asp?Ala?Leu?Ile?Ser?Asn?Ala?His?Thr?Tyr?Leu?Glu?Ala?Ser?Asp?Arg

200 205 210

gac?gag?gac?atc?gca?ttc?gtg?ctc?tca?cac?atc?atc?gag?ctc?aac?gaa 787

Asp?Glu?Asp?Ile?Ala?Phe?Val?Leu?Ser?His?Ile?Ile?Glu?Leu?Asn?Glu

215 220 225

cag?tac?ccc?ggc?gat?gtc?ggc 808

Gln?Tyr?Pro?Gly?Asp?Val?Gly

230 235

<210>358

<211>236

<212>PRT

＜213〉Corynebacterium glutamicum

<400>358

Met?Glu?Leu?Leu?Glu?Gly?Ser?Leu?Arg?Thr?Tyr?Pro?Trp?Gly?Ser?Arg

1 5 10 15

Thr?Leu?Ile?Ala?Asp?Leu?Lys?Gly?Glu?Glu?Ser?Pro?Ser?Ser?Arg?Pro

20 25 30

Glu?Ala?Glu?Val?Trp?Phe?Gly?Ala?His?Pro?Gly?Ser?Pro?Ser?Thr?Ile

35 40 45

Gly?Gly?Asn?Ala?Leu?Asn?Glu?Val?Ile?Ala?Ala?Asn?Pro?Glu?Glu?Ala

50 55 60

Leu?Gly?Thr?Arg?Val?Ala?Glu?Ala?Phe?Glu?Asn?Glu?Leu?Pro?Phe?Leu

65 70 75 80

Leu?Lys?Ile?Leu?Ala?Ala?Gly?Ala?Pro?Leu?Ser?Leu?Gln?Ala?His?Pro

85 90 95

Ser?Leu?Glu?Gln?Ala?Arg?Glu?Gly?Phe?Ala?Arg?Glu?Asn?Ser?Ala?Gly

100 105 110

Ile?Asp?Leu?Gly?Ala?Pro?Asn?Arg?Asn?Tyr?Arg?Asp?Pro?Asn?His?Lys

115 120 125

Pro?Glu?Leu?Ile?Val?Ala?Leu?Thr?Glu?Phe?Ile?Ala?Met?Ala?Gly?Phe

130 135 140

Arg?Pro?Leu?Arg?Asn?Thr?Leu?Thr?Ile?Phe?Asp?Ala?Leu?Ala?Cys?Glu

145 150 155 160

Pro?Leu?Asp?Arg?Tyr?Arg?Ser?Met?Leu?Thr?Val?Asp?Asn?Glu?Glu?Glu

165 170 175

Ser?Leu?Arg?Ala?Leu?Phe?Thr?Thr?Trp?Ile?Thr?Ile?Pro?Ile?Gly?Lys

180 185 190

Arg?His?Glu?Leu?Ile?Asp?Ala?Leu?Ile?Ser?Asn?Ala?His?Thr?Tyr?Leu

195 200 205

Glu?Ala?Ser?Asp?Arg?Asp?Glu?Asp?Ile?Ala?Phe?Val?Leu?Ser?His?Ile

210 215 220

Ile?Glu?Leu?Asn?Glu?Gln?Tyr?Pro?Gly?Asp?Val?Gly

225 230 235

<210>359

<21l>1775

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(1752)

<223>RXA02611

<400>359

gat?gcg?tgg?tcg?gat?cct?atg?gct?acg?tgg?cgt?cat?gcg?att?acc?act 48

Asp?Ala?Trp?Ser?Asp?Pro?Met?Ala?Thr?Trp?Arg?His?Ala?Ile?Thr?Thr

1 5 10 15

aag?att?gag?gcc?ggc?cag?ggt?tcg?gat?gag?ttg?tat?aac?gac?ttt?gag 96

Lys?Ile?Glu?Ala?Gly?Gln?Gly?Ser?Asp?Glu?Leu?Tyr?Asn?Asp?Phe?Glu

20 25 30

cac?ggg?gct?cag?ctg?ttt?gag?cgt?gct?gcg?gag?aat?ttg?tct?aaa?gag 144

His?Gly?Ala?Gln?Leu?Phe?Glu?Arg?Ala?Ala?Glu?Asn?Leu?Ser?Lys?Glu

35 40 45

gat?agg?act?gcg?ctt?ttc?gac?gtc?gcc?tcc?tct?ctg?cgg?cgc?ggc?ggc 192

Asp?Arg?Thr?Ala?Leu?Phe?Asp?Val?Ala?Ser?Ser?Leu?Arg?Arg?Gly?Gly

50 55 60

gat?gta?cgc?gca?cgt?ctc?gcc?cca?gcg?ctc?acc?gcg?agt?gtc?act?cat 240

Asp?Val?Arg?Ala?Arg?Leu?Ala?Pro?Ala?Leu?Thr?Ala?Ser?Val?Thr?His

65 70 75 80

ctt?tta?gaa?ctt?aac?ccg?ttg?cgt?gag?ttg?gtc?acg?atg?ggt?gaa?aac 288

Leu?Leu?Glu?Leu?Asn?Pro?Leu?Arg?Glu?Leu?Val?Thr?Met?Gly?Glu?Asn

85 90 95

ctg?cag?gtt?cgt?gtc?gag?cgt?cgt?gcc?gct?ttg?gtc?aac?tct?tgg?tat 336

Leu?Gln?Val?Arg?Val?Glu?Arg?Arg?Ala?Ala?Leu?Val?Asn?Ser?Trp?Tyr

100 105 110

gag?ctt?ttc?cct?cgt?tcc?aca?ggt?ggt?tgg?gat?gag?tcc?ggc?acc?ccc 384

Glu?Leu?Phe?Pro?Arg?Ser?Thr?Gly?Gly?Trp?Asp?Glu?Ser?Gly?Thr?Pro

115 120 125

gtt?cat?ggc?act?ttc?gct?acc?act?gct?cag?gcg?ttg?gag?cgt?gtc?gcg 432

Val?His?Gly?Thr?Phe?Ala?Thr?Thr?Ala?Gln?Ala?Leu?Glu?Arg?Val?Ala

130 135 140

aag?atg?ggc?ttc?gat?act?gtt?tac?ttc?ccg?ccg?atc?cat?ccg?att?ggc 480

Lys?Met?Gly?Phe?Asp?Thr?Val?Tyr?Phe?Pro?Pro?Ile?His?Pro?Ile?Gly

145 150 155 160

gag?gtc?aac?cgc?aag?ggc?cgc?aat?aat?acg?ctg?acc?ccg?gaa?cct?cat 528

Glu?Val?Asn?Arg?Lys?Gly?Arg?Asn?Asn?Thr?Leu?Thr?Pro?Glu?Pro?His

165 170 175

gat?gtg?ggt?tcg?ccg?tgg?gct?att?ggt?tct?aaa?gat?ggt?ggg?cat?gat 576

Asp?Val?Gly?Ser?Pro?Trp?Ala?Ile?Gly?Ser?Lys?Asp?Gly?Gly?His?Asp

180 185 190

gca?acg?cat?ccg?cgg?ttg?ggc?acc?att?gaa?gat?ttc?cag?gcg?ttg?ttg 624

Ala?Thr?His?Pro?Arg?Leu?Gly?Thr?Ile?Glu?Asp?Phe?Gln?Ala?Leu?Leu

195 200 205

gct?cgc?gca?cgg?gaa?ctc?aat?ttg?gaa?gtt?gca?ctc?gat?cta?gct?ctg 672

Ala?Arg?Ala?Arg?Glu?Leu?Asn?Leu?Glu?Val?Ala?Leu?Asp?Leu?Ala?Leu

210 215 220

cag?gct?gcc?cct?gat?cat?cca?tgg?gcg?cag?gaa?cac?cgc?gag?ttt?ttc 720

Gln?Ala?Ala?Pro?Asp?His?Pro?Trp?Ala?Gln?Glu?His?Arg?Glu?Phe?Phe

225 230 235 240

acg?gtg?ttg?gct?gat?ggc?acc?att?gcg?tat?gca?gaa?aac?cca?ccg?aag 768

Thr?Val?Leu?Ala?Asp?Gly?Thr?Ile?Ala?Tyr?Ala?Glu?Asn?Pro?Pro?Lys

245 250 255

aag?tac?cag?gat?att?tat?ccc?atc?aac?ttt?gat?aat?gat?gct?ccg?aag 816

Lys?Tyr?Gln?Asp?Ile?Tyr?Pro?Ile?Asn?Phe?Asp?Asn?Asp?Ala?Pro?Lys

260 265 270

atc?tac?gaa?gag?gtc?tat?cgt?gtg?gtg?aag?ttc?tgg?gtg?gat?ttg?ggt 864

Ile?Tyr?Glu?Glu?Val?Tyr?Arg?Val?Val?Lys?Phe?Trp?Val?Asp?Leu?Gly

275 280 285

gtg?acc?aca?ttc?cgc?gtg?gat?aac?ccg?cac?act?aag?ccc?gct?aat?ttc 912

Val?Thr?Thr?Phe?Arg?Val?Asp?Asn?Pro?His?Thr?Lys?Pro?Ala?Asn?Phe

290 295 300

tgg?cag?tgg?ctt?att?tct?gcc?atc?cat?aaa?tca?aac?cct?gag?gtc?att 960

Trp?Gln?Trp?Leu?Ile?Ser?Ala?Ile?His?Lys?Ser?Asn?Pro?Glu?Val?Ile

305 310 315 320

ttc?cta?gcg?gag?gcg?tct?act?cgc?ccg?gca?cgt?ctg?tat?ttc?ttg?tcc 1008

Phe?Leu?Ala?Glu?Ala?Ser?Thr?Arg?Pro?Ala?Arg?Leu?Tyr?Phe?Leu?Ser

325 330 335

aag?att?ggt?ttc?tcc?cag?tct?tac?acc?tac?ttc?acc?tgg?aag?gtc?acc 1056

Lys?Ile?Gly?Phe?Ser?Gln?Ser?Tyr?Thr?Tyr?Phe?Thr?Trp?Lys?Val?Thr

340 345 350

aac?gag?gag?ctc?acc?gag?ttc?gct?act?gag?atc?gcc?ccc?atg?gcg?gat 1104

Asn?Glu?Glu?Leu?Thr?Glu?Phe?Ala?Thr?Glu?Ile?Ala?Pro?Met?Ala?Asp

355 360 365

att?tct?cgt?ccg?aac?ctg?ttt?gtg?aac?act?ccc?gac?att?ttg?cat?gcg 1152

Ile?Ser?Arg?Pro?Asn?Leu?Phe?Val?Asn?Thr?Pro?Asp?Ile?Leu?His?Ala

370 375 380

tct?ctg?cag?cat?ggt?gga?cgc?gcc?atg?ttc?gct?atc?cgc?gcc?gca?ttg 1200

Ser?Leu?Gln?His?Gly?Gly?Arg?Ala?Met?Phe?Ala?Ile?Arg?Ala?Ala?Leu

385 390 395 400

gcc?gcc?acg?atg?tct?cct?gtg?tgg?ggc?gta?tat?tcc?gga?tat?gag?ctc 1248

Ala?Ala?Thr?Met?Ser?Pro?Val?Trp?Gly?Val?Tyr?Ser?Gly?Tyr?Glu?Leu

405 410 415

ttt?gag?cac?gag?gcc?gtc?aag?cct?ggt?tcg?gaa?gag?tac?ttg?gat?tct 1296

Phe?Glu?His?Glu?Ala?Val?Lys?Pro?Gly?Ser?Glu?Glu?Tyr?Leu?Asp?Ser

420 425 430

gag?aag?tac?gag?ctg?cgt?ccc?cgc?gat?ttc?gag?ggt?gct?ctg?gaa?cgt 1344

Glu?Lys?Tyr?Glu?Leu?Arg?Pro?Arg?Asp?Phe?Glu?Gly?Ala?Leu?Glu?Arg

435 440 445

ggc?gat?tct?ctc?gag?gat?tac?atc?gct?ctg?ctc?aac?cag?atc?cgt?cgc 1392

Gly?Asp?Ser?Leu?Glu?Asp?Tyr?Ile?Ala?Leu?Leu?Asn?Gln?Ile?Arg?Arg

450 455 460

gcg?aac?cct?gcc?ttg?cag?caa?cta?cgc?aac?atc?cac?ttc?cac?gaa?gcg 1440

Ala?Asn?Pro?Ala?Leu?Gln?Gln?Leu?Arg?Asn?Ile?His?Phe?His?Glu?Ala

465 470 475 480

gac?aat?gat?cag?atc?atc?gcc?tac?tcc?aag?gtt?gat?gct?ttg?acc?gga 1488

Asp?Asn?Asp?Gln?Ile?Ile?Ala?Tyr?Ser?Lys?Val?Asp?Ala?Leu?Thr?Gly

485 490 495

aat?acc?gtg?ttg?att?gtg?gtc?aac?ttg?gat?cca?cgt?agt?gct?cgt?gag 1536

Asn?Thr?Val?Leu?Ile?Val?Val?Asn?Leu?Asp?Pro?Arg?Ser?Ala?Arg?Glu

500 505 510

gct?act?gtt?cgc?ctt?gat?ctt?gga?gcg?ctt?ggc?tta?gaa?gcg?ggt?gca 1584

Ala?Thr?Val?Arg?Leu?Asp?Leu?Gly?Ala?Leu?Gly?Leu?Glu?Ala?Gly?Ala

515 520 525

cag?ttt?gag?gtg?cgc?gat?gcg?atc?acc?ggc?tcc?cgt?tac?ctg?tgg?tca 1632

Gln?Phe?Glu?Val?Arg?Asp?Ala?Ile?Thr?Gly?Ser?Arg?Tyr?Leu?Trp?Ser

530 535 540

gag?acg?aac?ttt?gtc?cgc?ctc?gag?ccc?cta?cgc?gat?gtc?gcc?cac?atc 1680

Glu?Thr?Asn?Phe?Val?Arg?Leu?Glu?Pro?Leu?Arg?Asp?Val?Ala?His?Ile

545 550 555 560

ttt?gtt?ctt?cct?gaa?ctt?cca?gcg?tct?cgc?cgt?gag?cgt?ctc?gcg?tgg 1728

Phe?Val?Leu?Pro?Glu?Leu?Pro?Ala?Ser?Arg?Arg?Glu?Arg?Leu?Ala?Trp

565 570 575

cgc?gaa?atc?aag?acc?tac?cgc?gcg?taatttccca?tctctgtacc?ttc 1775

Arg?Glu?Ile?Lys?Thr?Tyr?Arg?Ala

580

<210>360

<211>584

<212>PRT

＜213〉Corynebacterium glutamicum

<400>360

Asp?Ala?Trp?Ser?Asp?Pro?Met?Ala?Thr?Trp?Arg?His?Ala?Ile?Thr?Thr

1 5 10 15

Lys?Ile?Glu?Ala?Gly?Gln?Gly?Ser?Asp?Glu?Leu?Tyr?Asn?Asp?Phe?Glu

20 25 30

His?Gly?Ala?Gln?Leu?Phe?Glu?Arg?Ala?Ala?Glu?Asn?Leu?Ser?Lys?Glu

35 40 45

Asp?Arg?Thr?Ala?Leu?Phe?Asp?Val?Ala?Ser?Ser?Leu?Arg?Arg?Gly?Gly

50 55 60

Asp?Val?Arg?Ala?Arg?Leu?Ala?Pro?Ala?Leu?Thr?Ala?Ser?Val?Thr?His

65 70 75 80

Leu?Leu?Glu?Leu?Asn?Pro?Leu?Arg?Glu?Leu?Val?Thr?Met?GIy?Glu?Asn

85 90 95

Leu?Gln?Val?Arg?Val?Glu?Arg?Arg?Ala?Ala?Leu?Val?Asn?Ser?Trp?Tyr

100 105 110

Glu?Leu?Phe?Pro?Arg?Ser?Thr?Gly?Gly?Trp?Asp?Glu?Ser?Gly?Thr?Pro

115 120 125

Val?His?Gly?Thr?Phe?Ala?Thr?Thr?Ala?Gln?Ala?Leu?Glu?Arg?Val?Ala

130 135 140

Lys?Met?Gly?Phe?Asp?Thr?Val?Tyr?Phe?Pro?Pro?Ile?His?Pro?Ile?Gly

145 150 155 160

Glu?Val?Asn?Arg?Lys?Gly?Arg?Asn?Asn?Thr?Leu?Thr?Pro?Glu?Pro?His

165 170 175

Asp?Val?Gly?Ser?Pro?Trp?Ala?Ile?Gly?Ser?Lys?Asp?Gly?Gly?His?Asp

180 185 190

Ala?Thr?His?Pro?Arg?Leu?Gly?Thr?Ile?Glu?Asp?Phe?Gln?Ala?Leu?Leu

195 200 205

Ala?Arg?Ala?Arg?Glu?Leu?Asn?Leu?Glu?Val?Ala?Leu?Asp?Leu?Ala?Leu

210 215 220

Gln?Ala?Ala?Pro?Asp?His?Pro?Trp?Ala?Gln?Glu?His?Arg?Glu?Phe?Phe

225 230 235 240

Thr?Val?Leu?Ala?Asp?Gly?Thr?Ile?Ala?Tyr?Ala?Glu?Asn?Pro?Pro?Lys

245 250 255

Lys?Tyr?Gln?Asp?Ile?Tyr?Pro?Ile?Asn?Phe?Asp?Asn?Asp?Ala?Pro?Lys

260 265 270

Ile?Tyr?Glu?Glu?Val?Tyr?Arg?Val?Val?Lys?Phe?Trp?Val?Asp?Leu?Gly

275 280 285

Val?Thr?Thr?Phe?Arg?Val?Asp?Asn?Pro?His?Thr?Lys?Pro?Ala?Asn?Phe

290 295 300

Trp?Gln?Trp?Leu?Ile?Ser?Ala?Ile?His?Lys?Ser?Asn?Pro?Glu?Val?Ile

305 310 315 320

Phe?Leu?Ala?Glu?Ala?Ser?Thr?Arg?Pro?Ala?Arg?Leu?Tyr?Phe?Leu?Ser

325 330 335

Lys?Ile?Gly?Phe?Ser?Gln?Ser?Tyr?Thr?Tyr?Phe?Thr?Trp?Lys?Val?Thr

340 345 350

Asn?Glu?Glu?Leu?Thr?Glu?Phe?Ala?Thr?Glu?Ile?Ala?Pro?Met?Ala?Asp

355 360 365

Ile?Ser?Arg?Pro?Asn?Leu?Phe?Val?Asn?Thr?Pro?Asp?Ile?Leu?His?Ala

370 375 380

Ser?Leu?Gln?His?Gly?Gly?Arg?Ala?Met?Phe?Ala?Ile?Arg?Ala?Ala?Leu

385 390 395 400

Ala?Ala?Thr?Met?Ser?Pro?Val?Trp?Gly?Val?Tyr?Ser?Gly?Tyr?Glu?Leu

405 410 415

Phe?Glu?His?Glu?Ala?Val?Lys?Pro?Gly?Ser?Glu?Glu?Tyr?Leu?Asp?Ser

420 425 430

Glu?Lys?Tyr?Glu?Leu?Arg?Pro?Arg?Asp?Phe?Glu?Gly?Ala?Leu?Glu?Arg

435 440 445

Gly?Asp?Ser?Leu?Glu?Asp?Tyr?Ile?Ala?Leu?Leu?Asn?Gln?Ile?Arg?Arg

450 455 460

Ala?Asn?Pro?Ala?Leu?Gln?Gln?Leu?Arg?Asn?Ile?His?Phe?His?Glu?Ala

465 470 475 480

Asp?Asn?Asp?Gln?Ile?Ile?Ala?Tyr?Ser?Lys?Val?Asp?Ala?Leu?Thr?Gly

485 490 495

Asn?Thr?Val?Leu?Ile?Val?Val?Asn?Leu?Asp?Pro?Arg?Ser?Ala?Arg?Glu

500 505 510

Ala?Thr?Val?Arg?Leu?Asp?Leu?Gly?Ala?Leu?Gly?Leu?Glu?Ala?Gly?Ala

515 520 525

Gln?Phe?Glu?Val?Arg?Asp?Ala?Ile?Thr?Gly?Ser?Arg?Tyr?Leu?Trp?Ser

530 535 540

Glu?Thr?Asn?Phe?Val?Arg?Leu?Glu?Pro?Leu?Arg?Asp?Val?Ala?His?Ile

545 550 555 560

Phe?Val?Leu?Pro?Glu?Leu?Pro?Ala?Ser?Arg?Arg?Glu?Arg?Leu?Ala?Trp

565 570 575

Arg?Glu?Ile?Lys?Thr?Tyr?Arg?Ala

580

<210>361

<211>2316

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(2293)

<223>RXA02612

<400>361

gaacttccag?cgtctcgccg?tgagcgtctc?gcgtggcgcg?aaatcaagac?ctaccgcgcg?60

taatttccca?tctctgtacc?ttctatcaag?gattatcatc?atg?acc?gtt?gac?ccc 115

Met?Thr?Val?Asp?Pro

1 5

gcg?agc?cac?atc?acc?atc?cct?gaa?gca?gat?ctg?gcc?cgc?ctg?cgc?cac 163

Ala?Ser?His?Ile?Thr?Ile?Pro?Glu?Ala?Asp?Leu?Ala?Arg?Leu?Arg?His

10 15 20

tgc?aac?cat?cac?gat?cct?cat?gga?ttt?tat?ggt?tgg?cat?gag?acc?gaa 211

Cys?Asn?His?His?Asp?Pro?His?Gly?Phe?Tyr?Gly?Trp?His?Glu?Thr?Glu

25 30 35

gct?ggt?tcg?gtt?atc?cgc?acg?cgc?cag?gtc?ggc?gcg?acg?cag?gtt?aat 259

Ala?Gly?Ser?Val?Ile?Arg?Thr?Arg?Gln?Val?Gly?Ala?Thr?Gln?Val?Asn

40 45 50

ttg?ctt?atc?gac?gac?acc?tcc?cac?gtc?atg?acc?cct?atc?ggc?gac?gac 307

Leu?Leu?Ile?Asp?Asp?Thr?Ser?His?Val?Met?Thr?Pro?Ile?Gly?Asp?Asp

55 60 65

att?ttc?gca?att?gac?tta?ggt?cac?cgc?gag?cgc?gct?gac?tat?cgc?ttg 355

Ile?Phe?Ala?Ile?Asp?Leu?Gly?His?Arg?Glu?Arg?Ala?Asp?Tyr?Arg?Leu

70 75 80 85

gaa?gtc?acc?tgg?cct?gat?caa?gaa?ccg?cag?gtc?aag?gct?gat?cca?tac 403

Glu?Val?Thr?Trp?Pro?Asp?Gln?Glu?Pro?Gln?Val?Lys?Ala?Asp?Pro?Tyr

90 95 100

tac?ttc?ctc?ccc?acc?gta?ggc?gag?atg?gat?att?tac?ctc?ttc?tct?gag 451

Tyr?Phe?Leu?Pro?Thr?Val?Gly?Glu?Met?Asp?Ile?Tyr?Leu?Phe?Ser?Glu

105 110 115

gga?cgc?cat?gag?cgt?ttg?tgg?gag?att?ctc?ggt?gcc?aac?atc?aag?acc 499

Gly?Arg?His?Glu?Arg?Leu?Trp?Glu?Ile?Leu?Gly?Ala?Asn?Ile?Lys?Thr

120 125 130

tac?caa?act?gcg?ctc?gga?sca?gtt?cgt?ggc?acc?gcs?ttt?act?gtg?tgg 547

Tyr?Gln?Thr?Ala?Leu?Gly?Thr?Val?Arg?Gly?Thr?Als?Phe?Thr?Vsl?Trp

135 140 145

gct?cca?aac?gca?att?ggc?tgc?gca?gtg?gtc?ggt?ggc?ttc?aac?ggt?tgg 595

Ala?Pro?Asn?Als?Ile?Gly?Cys?Ala?Val?Val?Gly?Gly?Phe?Asn?Gly?Trp

150 155 160 165

aat?gca?tcc?cag?cat?ccg?atg?cgt?tct?atg?ggt?ggt?tcg?ggt?ctg?tgg 643

Asn?Ala?Ser?Gln?His?Pro?Met?Arg?Ser?Met?Gly?Gly?Ser?Gly?Leu?Trp

170 175 180

gag?ctg?ttc?atc?cca?ggc?ata?gag?gaa?ggc?gaa?gtg?tac?aaa?ttc?gcc 691

Glu?Leu?Phe?Ile?Pro?Gly?Ile?Glu?Glu?Gly?Glu?Val?Tyr?Lys?Phe?Ala

185 190 195

gtc?caa?acc?agg?gaa?ggc?caa?cgt?cgt?gat?aag?gcc?gat?ccg?atg?gct 739

Val?Gln?Thr?Arg?Glu?Gly?Gln?Arg?Arg?Asp?Lys?Ala?Asp?Pro?Met?Ala

200 205 210

cgt?cgc?gca?gaa?ctg?gcg?ccg?gca?acc?gga?tct?att?gtc?gct?tcc?tct 787

Arg?Arg?Ala?Glu?Leu?Ala?Pro?Ala?Thr?Gly?Ser?Ile?Val?Ala?Ser?Ser

215 220 225

gag?tsc?cag?tgg?cag?gat?tcc?gag?tgg?ctg?cgc?gag?cgt?tcc?caa?act 835

Glu?Tyr?Gln?Trp?Gln?Asp?Ser?Glu?Trp?Leu?Arg?Glu?Arg?Ser?Gln?Thr

230 235 240 245

gat?ctc?gca?tcc?aag?cca?atg?agt?gtc?tac?gag?gtc?cac?ctc?ggt?tct 883

Asp?Leu?Ala?Ser?Lys?Pro?Met?Ser?Val?Tyr?Glu?Val?His?Leu?Gly?Ser

250 255 260

tgg?cgc?tgg?ggt?aag?aac?tat?gag?gat?ttg?gct?act?gag?ctg?gtt?gat 931

Trp?Arg?Trp?Gly?Lys?Asn?Tyr?Glu?Asp?Leu?Ala?Thr?Glu?Leu?Val?Asp

265 270 275

tac?gtc?gca?gat?ctt?ggc?tac?acc?cac?gtg?gaa?ttc?ctc?cct?gtc?gca 979

Tyr?Val?Ala?Asp?Leu?Gly?Tyr?Thr?His?Val?Glu?Phe?Leu?Pro?Val?Ala

280 285 290

gag?cac?ccc?ttc?ggt?ggt?tcc?tgg?ggt?tac?cag?gtc?acc?ggc?tac?tac 1027

Glu?His?Pro?Phe?Gly?Gly?Ser?Trp?Gly?Tyr?Gln?Val?Thr?Gly?Tyr?Tyr

295 300 305

gca?ccg?acc?tct?cgt?tgg?ggt?act?cca?gat?cag?ttc?cgt?gcg?cta?gtc 1075

Ala?Pro?Thr?Ser?Arg?Trp?Gly?Thr?Pro?Asp?Gln?Phe?Arg?Ala?Leu?Val

310 315 320 325

gac?gct?ttc?cac?gcc?cgc?ggt?att?ggc?gtg?atc?atg?gac?tgg?gtt?cct 1123

Asp?Ala?Phe?His?Ala?Arg?Gly?Ile?Gly?Val?Ile?Met?Asp?Trp?Val?Pro

330 335 340

gcc?cac?ttc?cct?aag?gat?gat?tgg?gct?ctt?gcc?cgc?ttt?gat?ggc?gaa 1171

Ala?His?Phe?Pro?Lys?Asp?Asp?Trp?Ala?Leu?Ala?Arg?Phe?Asp?Gly?Glu

345 350 355

gcc?ctc?tat?gaa?cac?cct?gac?tgg?agg?cgc?ggc?gaa?caa?sag?gat?tgg 1219

Ala?Leu?Tyr?Glu?His?Pro?Asp?Trp?Arg?Arg?Gly?Glu?Gln?Lys?Asp?Trp

360 365 370

ggc?acc?ctg?gtc?ttt?gac?ttc?ggt?cgc?aac?gaa?gtc?cgc?aac?ttc?ctc 1267

Gly?Thr?Leu?Val?Phe?Asp?Phe?Gly?Arg?Asn?Glu?Val?Arg?Asn?Phe?Leu

375 380 385

gtc?gct?aat?gcg?ttg?tac?tgg?att?gaa?gaa?ttc?cac?atc?gat?ggt?ctg 1315

Val?Ala?Asn?Ala?Leu?Tyr?Trp?Ile?Glu?Glu?Phe?His?Ile?Asp?Gly?Leu

390 395 400 405

cgc?gtc?gac?gcc?gtg?gcc?tcc?atg?ctg?tac?ctc?gat?tac?tcc?cgt?gag 1363

Arg?Val?Asp?Ala?Val?Ala?Ser?Met?Leu?Tyr?Leu?Asp?Tyr?Ser?Arg?Glu

410 415 420

cac?ggc?gaa?tgg?gaa?cca?aac?atc?tac?ggt?ggt?cgc?gag?aac?ctc?gag 1411

His?Gly?Glu?Trp?Glu?Pro?Asn?Ile?Tyr?Gly?Gly?Arg?Glu?Asn?Leu?Glu

425 430 435

gca?gtg?cag?ttc?ctg?cag?gaa?atg?aac?gcc?acg?gtg?ctg?cga?ctg?cac 1459

Ala?Val?Gln?Phe?Leu?Gln?Glu?Met?Asn?Ala?Thr?Val?Leu?Arg?Leu?His

440 445 450

cct?ggt?gcg?ctc?acc?atc?gct?gag?gaa?tca?act?tca?tgg?cct?ggc?gtg 1507

Pro?Gly?Ala?Leu?Thr?Ile?Ala?Glu?Glu?Ser?Thr?Ser?Trp?Pro?Gly?Val

455 460 465

acc?gca?cca?acg?tgg?gac?ggc?ggc?ttg?gga?ttc?tcc?ctc?aag?tgg?aac 1555

Thr?Ala?Pro?Thr?Trp?Asp?Gly?Gly?Leu?Gly?Phe?Ser?Leu?Lys?Trp?Asn

470 475 480 485

atg?ggc?tgg?atg?cac?gac?acc?tta?gag?tac?ttc?tcc?aaa?aac?cct?gtg 1603

Met?Gly?Trp?Met?His?Asp?Thr?Leu?Glu?Tyr?Phe?Ser?Lys?Asn?Pro?Val

490 495 500

cac?cgc?gca?ttc?cac?cac?agt?gag?ctc?act?ttc?tcc?ttg?gtg?tac?gca 1651

His?Arg?Ala?Phe?His?His?Ser?Glu?Leu?Thr?Phe?Ser?Leu?Val?Tyr?Ala

505 510 515

ttc?tct?gag?cgt?ttt?gta?ctt?ccg?atc?tct?cac?gat?gaa?gtc?gtc?cac 1699

Phe?Ser?Glu?Arg?Phe?Val?Leu?Pro?Ile?Ser?His?Asp?Glu?Val?Val?His

520 525 530

ggc?aag?ggt?tcc?ctg?tgg?gac?cgt?atg?cct?ggc?gat?acg?tgg?aac?aag 1747

Gly?Lys?Gly?Ser?Leu?Trp?Asp?Arg?Met?Pro?Gly?Asp?Thr?Trp?Asn?Lys

535 540 545

gcc?gct?ggt?ctt?cgc?acc?ttc?ctt?gcg?tac?atg?tgg?tca?cac?cca?ggc 1795

Ala?Ala?Gly?Leu?Arg?Thr?Phe?Leu?Ala?Tyr?Met?Trp?Ser?His?Pro?Gly

550 555 560 565

aag?aag?ctg?ctt?ttc?atg?ggt?cag?gag?ttt?ggt?cag?cgt?gaa?gag?tgg 1843

Lys?Lys?Leu?Leu?Phe?Met?Gly?Gln?Glu?Phe?Gly?Gln?Arg?Glu?Glu?Trp

570 575 580

gct?gaa?ggc?cag?gga?ctg?cca?tgg?gat?att?gtc?gac?ggc?tgg?caa?ggc 1891

Ala?Glu?Gly?Gln?Gly?Leu?Pro?Trp?Asp?Ile?Val?Asp?Gly?Trp?Gln?Gly

585 590 595

gag?tac?cac?gaa?gcc?atc?cgc?act?ctg?acc?cgc?tcc?ctc?aac?ggt?gtc 1939

Glu?Tyr?His?Glu?Ala?Ile?Arg?Thr?Leu?Thr?Arg?Ser?Leu?Asn?Gly?Val

600 605 610

tac?tca?gac?tcc?cct?gcg?ctg?cac?act?cag?gat?ttc?acc?gga?gaa?ggc 1987

Tyr?Ser?Asp?Ser?Pro?Ala?Leu?His?Thr?Gln?Asp?Phe?Thr?Gly?Glu?Gly

615 620 625

ttc?aca?tgg?aat?aag?ggc?gac?gac?gcc?acc?aac?aac?att?ttg?gcg?ttc 2035

Phe?Thr?Trp?Asn?Lys?Gly?Asp?Asp?Ala?Thr?Asn?Asn?Ile?Leu?Ala?Phe

630 635 640 645

act?cgt?ttc?ggc?agc?gac?ggc?tcc?cag?atg?ctg?tgt?gta?ttc?aac?ctg 2083

Thr?Arg?Phe?Gly?Ser?Asp?Gly?Ser?Gln?Met?Leu?Cys?Val?Phe?Asn?Leu

650 655 660

tct?gga?acc?tcc?cag?cct?gag?tac?cag?ctc?ggt?gtt?gca?gcg?ggt?ggc 2131

Ser?Gly?Thr?Ser?Gln?Pro?Glu?Tyr?Gln?Leu?Gly?Val?Ala?Ala?Gly?Gly

665 670 675

gaa?tgg?aag?ctc?gtt?ctc?aac?act?gat?gat?gct?gaa?ttc?ctc?ggt?gca 2179

Glu?Trp?Lys?Leu?Val?Leu?Asn?Thr?Asp?Asp?Ala?Glu?Phe?Leu?Gly?Ala

680 685 690

gaa?aac?gat?atc?gct?act?tcc?gtt?caa?gca?gca?gcg?aca?cca?cgc?gat 2227

Glu?Asn?Asp?Ile?Ala?Thr?Ser?Val?Gln?Ala?Ala?Ala?Thr?Pro?Arg?Asp

695 700 705

aat?ttc?gcc?tac?tca?ctc?tca?ctg?cat?gtc?cca?gcg?atg?agt?gct?cag 2275

Asn?Phe?Ala?Tyr?Ser?Leu?Ser?Leu?His?Val?Pro?Ala?Met?Ser?Ala?Gln

710 715 720 725

ttc?tac?tca?ctg?cag?aag?taggacacag?gaaaatgcat?cct 2316

Phe?Tyr?Ser?Leu?Gln?Lys

730

<210>362

<211>731

<212>PRT

＜213〉Corynebacterium glutamicum

<400>362

Met?Thr?Val?Asp?Pro?Ala?Ser?His?Ile?Thr?Ile?Pro?Glu?Ala?Asp?Leu

1 5 10 15

Ala?Arg?Leu?Arg?His?Cys?Asn?His?His?Asp?Pro?His?Gly?Phe?Tyr?Gly

20 25 30

Trp?His?Glu?Thr?Glu?Ala?Gly?Ser?Val?Ile?Arg?Thr?Arg?Gln?Val?Gly

35 40 45

Ala?Thr?Gln?Val?Asn?Leu?Leu?Ile?Asp?Asp?Thr?Ser?His?Val?Met?Thr

50 55 60

Pro?Ile?Gly?Asp?Asp?Ile?Phe?Ala?Ile?Asp?Leu?Gly?His?Arg?Glu?Arg

65 70 75 80

Ala?Asp?Tyr?Arg?Leu?Glu?Val?Thr?Trp?Pro?Asp?Gln?Glu?Pro?Gln?Val

85 90 95

Lys?Ala?Asp?Pro?Tyr?Tyr?Phe?Leu?Pro?Thr?Val?Gly?Glu?Met?Asp?Ile

100 105 110

Tyr?Leu?Phe?Ser?Glu?Gly?Arg?His?Glu?Arg?Leu?Trp?Glu?Ile?Leu?Gly

115 120 125

Ala?Asn?Ile?Lys?Thr?Tyr?Gln?Thr?Ala?Leu?Gly?Thr?Val?Arg?Gly?Thr

130 135 140

Ala?Phe?Thr?Val?Trp?Ala?Pro?Asn?Ala?Ile?Gly?Cys?Ala?Val?Val?Gly

145 150 155 160

Gly?Phe?Asn?Gly?Trp?Asn?Ala?Ser?Gln?His?Pro?Met?Arg?Ser?Met?Gly

165 170 175

Gly?Ser?Gly?Leu?Trp?Glu?Leu?Phe?Ile?Pro?Gly?Ile?Glu?Glu?Gly?Glu

180 185 190

Val?Tyr?Lys?Phe?Ala?Gal?Gln?Thr?Arg?Glu?Gly?Gln?Arg?Arg?Asp?Lys

195 200 205

Ala?Asp?Pro?Met?Ala?Arg?Arg?Ala?Glu?Leu?Ala?Pro?Ala?Thr?Gly?Ser

210 215 220

Ile?Val?Ala?Ser?Ser?Glu?Tyr?Gln?Trp?Gln?Asp?Ser?Glu?Trp?Leu?Arg

225 230 235 240

Glu?Arg?Ser?Gln?Thr?Asp?Leu?Ala?Ser?Lys?Pro?Met?Ser?Val?Tyr?Glu

245 250 255

Val?His?Leu?Gly?Ser?Trp?Arg?Trp?Gly?Lys?Asn?Tyr?Glu?Asp?Leu?Ala

260 265 270

Thr?Glu?Leu?Val?Asp?Tyr?Val?Ala?Asp?Leu?Gly?Tyr?Thr?His?Val?Glu

275 280 285

Phe?Leu?Pro?Val?Ala?Glu?His?Pro?Phe?Gly?Gly?Ser?Trp?Gly?Tyr?Gln

290 295 300

Val?Thr?Gly?Tyr?Tyr?Ala?Pro?Thr?Ser?Arg?Trp?Gly?Thr?Pro?Asp?Gln

305 310 315 320

Phe?Arg?Ala?Leu?Val?Asp?Ala?Phe?His?Ala?Arg?Gly?Ile?Gly?Val?Ile

325 330 335

Met?Asp?Trp?Val?Pro?Ala?His?Phe?Pro?Lys?Asp?Asp?Trp?Ala?Leu?Ala

340 345 350

Arg?Phe?Asp?Gly?Glu?Ala?Leu?Tyr?Glu?His?Pro?Asp?Trp?Arg?Arg?Gly

355 360 365

Glu?Gln?Lys?Asp?Trp?Gly?Thr?Leu?Val?Phe?Asp?Phe?Gly?Arg?Asn?Glu

370 375 380

Val?Arg?Asn?Phe?Leu?Val?Ala?Asn?Ala?Leu?Tyr?Trp?Ile?Glu?Glu?Phe

385 390 395 400

His?Ile?Asp?Gly?Leu?Arg?Val?Asp?Ala?Val?Ala?Ser?Met?Leu?Tyr?Leu

405 410 415

Asp?Tyr?Ser?Arg?Glu?His?Gly?Glu?Trp?Glu?Pro?Asn?Ile?Tyr?Gly?Gly

420 425 430

Arg?Glu?Asn?Leu?Glu?Ala?Val?Gln?Phe?Leu?Gln?Glu?Met?Asn?Ala?Thr

435 440 445

Val?Leu?Arg?Leu?His?Pro?Gly?Ala?Leu?Thr?Ile?Ala?Glu?Glu?Ser?Thr

450 455 460

Ser?Trp?Pro?Gly?Val?Thr?Ala?Pro?Thr?Trp?Asp?Gly?Gly?Leu?Gly?Phe

465 470 475 480

Ser?Leu?Lys?Trp?Asn?Met?Gly?Trp?Met?His?Asp?Thr?Leu?Glu?Tyr?Phe

485 490 495

Ser?Lys?Asn?Pro?Val?His?Arg?Ala?Phe?His?His?Ser?Glu?Leu?Thr?Phe

500 505 510

Ser?Leu?Val?Tyr?Ala?Phe?Ser?Glu?Arg?Phe?Val?Leu?Pro?Ile?Ser?His

515 520 525

Asp?Glu?Val?Val?His?Gly?Lys?Gly?Ser?Leu?Trp?Asp?Arg?Met?Pro?Gly

530 535 540

Asp?Thr?Trp?Asn?Lys?Ala?Ala?Gly?Leu?Arg?Thr?Phe?Leu?Ala?Tyr?Met

545 550 555 560

Trp?Ser?His?Pro?Gly?Lys?Lys?Leu?Leu?Phe?Met?Gly?Gln?Glu?Phe?Gly

565 570 575

Gln?Arg?Glu?Glu?Trp?Ala?Glu?Gly?Gln?Gly?Leu?Pro?Trp?Asp?Ile?Val

580 585 590

Asp?Gly?Trp?Gln?Gly?Glu?Tyr?His?Glu?Ala?Ile?Arg?Thr?Leu?Thr?Arg

595 600 605

Ser?Leu?Asn?Gly?Val?Tyr?Ser?Asp?Ser?Pro?Ala?Leu?His?Thr?Gln?Asp

610 615 620

Phe?Thr?Gly?Glu?Gly?Phe?Thr?Trp?Asn?Lys?Gly?Asp?Asp?Ala?Thr?Asn

625 630 635 640

Asn?Ile?Leu?Ala?Phe?Thr?Arg?Phe?Gly?Ser?Asp?Gly?Ser?Gln?Met?Leu

645 650 655

Cys?Val?Phe?Asn?Leu?Ser?Gly?Thr?Ser?Gln?Pro?Glu?Tyr?Gln?Leu?Gly

660 665 670

Val?Ala?Ala?Gly?Gly?Glu?Trp?Lys?Leu?Val?Leu?Asn?Thr?Asp?Asp?Ala

675 680 685

Glu?Phe?Leu?Gly?Ala?Glu?Asn?Asp?Ile?Ala?Thr?Ser?Val?Gln?Ala?Ala

690 695 700

Ala?Thr?Pro?Arg?Asp?Asn?Phe?Ala?Tyr?Ser?Leu?Ser?Leu?His?Val?Pro

705 710 715 720

Ala?Met?Ser?Ala?Gln?Phe?Tyr?Ser?Leu?Gln?Lys

725 730

<210>363

<211>1913

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(1890)

<223>RXN01884

<400>363

gtg?act?gcc?att?gaa?ttg?atg?ccg?gtc?cac?cag?ttc?ctg?cag?gat?gat 48

Val?Thr?Ala?Ile?Glu?Leu?Met?Pro?Val?His?Gln?Phe?Leu?Gln?Asp?Asp

1 5 10 15

cgt?ctc?cgc?gac?cta?gga?atg?cgc?aac?tac?tgg?ggc?tac?aac?tct?ttc 96

Arg?Leu?Arg?Asp?Leu?Gly?Met?Arg?Asn?Tyr?Trp?Gly?Tyr?Asn?Ser?Phe

20 25 30

ggc?ttc?ttt?gcg?ccc?tac?aac?gat?tac?gct?gcc?aac?aag?aac?ccc?ggt 144

Gly?Phe?Phe?Ala?Pro?Tyr?Asn?Asp?Tyr?Ala?Ala?Asn?Lys?Asn?Pro?Gly

35 40 45

ggc?gcc?gtg?gcc?gag?ttc?aaa?ggc?ttg?gtg?cgc?agc?tac?cac?gaa?gcg 192

Gly?Ala?Val?Ala?Glu?Phe?Lys?Gly?Leu?Val?Arg?Ser?Tyr?His?Glu?Ala

50 55 60

ggc?ctc?gaa?gta?att?ttg?gat?gtg?gtc?tac?aac?cac?acc?gcc?gag?ggc 240

Gly?Leu?Glu?Val?Ile?Leu?Asp?Val?Val?Tyr?Asn?His?Thr?Ala?Glu?Gly

65 70 75 80

aac?cac?atg?ggc?ccc?acc?atc?gcg?ttc?cga?ggc?att?gac?aac?gag?gcg 288

Asn?His?Met?Gly?Pro?Thr?Ile?Ala?Phe?Arg?Gly?Ile?Asp?Asn?Glu?Ala

85 90 95

tac?tac?cga?ctg?gtt?gag?ggc?gat?cgc?cgt?cat?tac?atg?gac?tac?acc 336

Tyr?Tyr?Arg?Leu?Val?Glu?Gly?Asp?Arg?Arg?His?Tyr?Met?Asp?Tyr?Thr

100 105 110

ggt?act?ggt?aac?tcc?ctc?aat?gtc?cgc?gac?ccg?cac?tca?ctg?cag?ctg 384

Gly?Thr?Gly?Asn?Ser?Leu?Asn?Val?Arg?Asp?Pro?His?Ser?Leu?Gln?Leu

115 120 125

att?atg?gat?tcg?ctg?cgc?tac?tgg?gtc?acc?gag?atg?cat?gtc?gac?ggc 432

Ile?Met?Asp?Ser?Leu?Arg?Tyr?Trp?Val?Thr?Glu?Met?His?Val?Asp?Gly

130 135 140

ttc?cgc?ttc?gac?ctt?gcc?tct?acc?ctt?gct?cgt?gaa?ttt?gat?gat?gtt 480

Phe?Arg?Phe?Asp?Leu?Ala?Ser?Thr?Leu?Ala?Arg?Glu?Phe?Asp?Asp?Val

145 150 155 160

gac?cgc?ctg?gca?acc?ttc?ttc?gac?ctg?gtc?caa?caa?gac?ccg?gtg?gtc 528

Asp?Arg?Leu?Ala?Thr?Phe?Phe?Asp?Leu?Val?Gln?Gln?Asp?Pro?Val?Val

165 170 175

tcc?cag?gtc?aag?ctc?att?gct?gag?ccg?tgg?gat?gtt?ggc?gaa?ggc?gga 576

Ser?Gln?Val?Lys?Leu?Ile?Ala?Glu?Pro?Trp?Asp?Val?Gly?Glu?Gly?Gly

180 185 190

tac?caa?gtg?ggt?aac?ttc?cca?cca?ctg?tgg?act?gag?tgg?aac?ggt?aaa 624

Tyr?Gln?Val?Gly?Asn?Phe?Pro?Pro?Leu?Trp?Thr?Glu?Trp?Asn?Gly?Lys

195 200 205

tac?cgc?gac?act?gtc?cgt?gat?ttc?tgg?cgt?ggt?gag?cca?gca?acc?ttg 672

Tyr?Arg?Asp?Thr?Val?Arg?Asp?Phe?Trp?Arg?Gly?Glu?Pro?Ala?Thr?Leu

210 215 220

ggt?gaa?ttc?gct?tcc?cga?cta?act?ggt?tcc?tot?gat?ttg?tat?gca?aac 720

Gly?Glu?Phe?Ala?Ser?Arg?Leu?Thr?Gly?Ser?Ser?Asp?Leu?Tyr?Ala?Asn

225 230 235 240

aac?ggc?cgt?cgc?ccc?act?gca?tcg?atc?aac?ttt?gtg?act?gct?cac?gac 768

Asn?Gly?Arg?Arg?Pro?Thr?Ala?Ser?Ile?Asn?Phe?Val?Thr?Ala?His?Asp

245 250 255

ggc?ttc?acc?ctc?aat?gac?ttg?gtc?agt?tac?aac?gag?aag?cac?aac?atg 816

Gly?Phe?Thr?Leu?Asn?Asp?Leu?Val?Ser?Tyr?Asn?Glu?Lys?His?Asn?Met

260 265 270

gcc?aac?ggt?gaa?gac?ggt?cgg?gac?ggt?gaa?tca?cac?aac?cgt?tcc?tgg 864

Ala?Asn?Gly?Glu?Asp?Gly?Arg?Asp?Gly?Glu?Ser?His?Asn?Arg?Ser?Trp

275 280 285

aac?tgt?ggc?gtc?gaa?gga?cca?act?gac?gat?cct?gag?att?atg?cag?ctg 912

Asn?Cys?Gly?Val?Glu?Gly?Pro?Thr?Asp?Asp?Pro?Glu?Ile?Met?Gln?Leu

290 295 300

cgt?gct?cag?caa?cga?cgc?aac?ttc?ctc?acc?acc?ttg?ttg?ctg?tcc?cag 960

Arg?Ala?Gln?Gln?Arg?Arg?Asn?Phe?Leu?Thr?Thr?Leu?Leu?Leu?Ser?Gln

305 310 315 320

ggc?acc?cct?atg?ttg?tcc?cac?ggt?gat?gaa?atg?gcc?cgt?acc?caa?aac 1008

Gly?Thr?Pro?Met?Leu?Ser?His?Gly?Asp?Glu?Met?Ala?Arg?Thr?Gln?Asn

325 330 335

ggc?aac?aac?aac?gtc?tac?tgc?caa?gac?aat?gaa?ctg?gcg?tgg?gtg?aat 1056

Gly?Asn?Asn?Asn?Val?Tyr?Cys?Gln?Asp?Asn?Glu?Leu?Ala?Trp?Val?Asn

340 345 350

tgg?gat?cag?gct?gaa?gaa?aac?gct?gac?ttg?gtg?agc?ttc?acc?agg?cgt 1104

Trp?Asp?Gln?Ala?Glu?Glu?Asn?Ala?Asp?Leu?Val?Ser?Phe?Thr?Arg?Arg

355 360 365

ttg?ctg?cgt?atc?cga?gca?aac?cac?cca?gta?ttt?agg?cgc?agg?cag?ttc 1152

Leu?Leu?Arg?Ile?Arg?Ala?Asn?His?Pro?Val?Phe?Arg?Arg?Arg?Gln?Phe

370 375 380

ctt?gcc?ggt?ggc?cct?ttg?ggc?gcc?gat?gtt?cgt?gac?cgc?gat?atc?gca 1200

Leu?Ala?Gly?Gly?Pro?Leu?Gly?Ala?Asp?Val?Arg?Asp?Arg?Asp?Ile?Ala

385 390 395 400

tgg?ctg?gta?cca?aat?gga?acc?ttg?atg?act?caa?gat?gac?tgg?gac?ttc 1248

Trp?Leu?Val?Pro?Asn?Gly?Thr?Leu?Met?Thr?Gln?Asp?Asp?Trp?Asp?Phe

405 410 415

gct?ttc?ggt?aaa?tca?ctg?cag?gtg?ttc?ttc?aac?ggc?gat?gcc?atc?gaa 1296

Ala?Phe?Gly?Lys?Ser?Leu?Gln?Val?Phe?Phe?Asn?Gly?Asp?Ala?Ile?Glu

420 425 430

gag?cct?gat?tat?cga?gga?cag?aaa?atc?cac?gat?gac?tcc?ttc?atc?ttg 1344

Glu?Pro?Asp?Tyr?Arg?Gly?Gln?Lys?Ile?His?Asp?Asp?Ser?Phe?Ile?Leu

435 440 445

atg?ttc?aac?gct?cac?ttc?gaa?cct?atc?gat?ttc?aat?ctc?cct?cct?gag 1392

Met?Phe?Asn?Ala?His?Phe?Glu?Pro?Ile?Asp?Phe?Asn?Leu?Pro?Pro?Glu

450 455 460

cat?ttc?ggt?atg?aag?tgg?aag?ctt?ttg?gtc?gat?acc?acc?gaa?gcg?gtg 1440

His?Phe?Gly?Met?Lys?Trp?Lys?Leu?Leu?Val?Asp?Thr?Thr?Glu?Ala?Val

465 470 475 480

ggc?cac?ccg?ctg?gag?gat?ctc?acc?atc?gaa?gct?ggc?gga?acc?atc?act 1488

Gly?His?Pro?Leu?Glu?Asp?Leu?Thr?Ile?Glu?Ala?Gly?Gly?Thr?Ile?Thr

485 490 495

gtt?cct?gcc?cgt?tcc?acg?atg?ctg?ctg?cgc?cag?gtg?gag?gct?ccg?gac 1536

Val?Pro?Ala?Arg?Ser?Thr?Met?Leu?Leu?Arg?Gln?Val?Glu?Ala?Pro?Asp

500 505 510

tac?acc?aag?ctt?gag?gaa?aag?atc?gct?gct?gaa?aag?cgt?gag?caa?gaa 1584

Tyr?Thr?Lys?Leu?Glu?Glu?Lys?Ile?Ala?Ala?Glu?Lys?Arg?Glu?Gln?Glu

515 520 525

ctt?gcg?gca?gag?aag?gaa?gct?gct?gag?aag?cgc?gaa?ttg?gaa?ctg?gcg 1632

Leu?Ala?Ala?Glu?Lys?Glu?Ala?Ala?Glu?Lys?Arg?Glu?Leu?Glu?Leu?Ala

530 535 540

gca?gca?aag?gaa?gct?gaa?gat?gct?gct?gag?gct?ctc?cac?ctt?gcg?gca 1680

Ala?Ala?Lys?Glu?Ala?Glu?Asp?Ala?Ala?Glu?Ala?Leu?His?Leu?Ala?Ala

545 550 555 560

gaa?cgt?gct?tcg?act?cag?gaa?gct?gaa?ttg?gcc?cat?caa?cac?ggt?gct 1728

Glu?Arg?Ala?Ser?Thr?Gln?Glu?Ala?Glu?Leu?Ala?His?Gln?His?Gly?Ala

565 570 575

gat?gcg?att?gcc?gat?gag?gta?gcg?gaa?gaa?cca?caa?gag?ctg?cca?caa 1776

Asp?Ala?Ile?Ala?Asp?Glu?Val?Ala?Glu?Glu?Pro?Gln?Glu?Leu?Pro?Gln

580 585 590

gat?gaa?gta?gcg?gca?gag?gtc?gag?act?gag?ccc?gac?acc?gag?cct?gac 1824

Asp?Glu?Val?Ala?Ala?Glu?Val?Glu?Thr?Glu?Pro?Asp?Thr?Glu?Pro?Asp

595 600 605

act?gaa?tct?gac?tcc?gag?cag?gct?gag?gta?gct?tca?gag?gag?cct?gaa 1872

Thr?Glu?Ser?Asp?Ser?Glu?Gln?Ala?Glu?Val?Ala?Ser?Glu?Glu?Pro?Glu

610 615 620

gcg?gac?gaa?gaa?gag?aag?tagtacaccg?aaagtggcgt?cgc 1913

Ala?Asp?Glu?Glu?Glu?Lys

625 630

<210>364

<211>630

<212>PRT

＜213〉Corynebacterium glutamicum

<400>364

Val?Thr?Ala?Ile?Glu?Leu?Met?Pro?Val?His?Gln?Phe?Leu?Gln?Asp?Asp

1 5 10 15

Arg?Leu?Arg?Asp?Leu?Gly?Met?Arg?Asn?Tyr?Trp?Gly?Tyr?Asn?Ser?Phe

20 25 30

Gly?Phe?Phe?Ala?Pro?Tyr?Asn?Asp?Tyr?Ala?Ala?Asn?Lys?Asn?Pro?Gly

35 40 45

Gly?Ala?Val?Ala?Glu?Phe?Lys?Gly?Leu?Val?Arg?Ser?Tyr?His?Glu?Ala

50 55 60

Gly?Leu?Glu?Val?Ile?Leu?Asp?Val?Val?Tyr?Asn?His?Thr?Ala?Glu?Gly

65 70 75 80

Asn?His?Met?Gly?Pro?Thr?Ile?Ala?Phe?Arg?Gly?Ile?Asp?Asn?Glu?Ala

85 90 95

Tyr?Tyr?Arg?Leu?Val?Glu?Gly?Asp?Arg?Arg?His?Tyr?Met?Asp?Tyr?Thr

100 105 110

Gly?Thr?Gly?Asn?Ser?Leu?Asn?Val?Arg?Asp?Pro?His?Ser?Leu?Gln?Leu

115 120 125

Ile?Met?Asp?Ser?Leu?Arg?Tyr?Trp?Val?Thr?Glu?Met?His?Val?Asp?Gly

130 135 140

Phe?Arg?Phe?Asp?Leu?Ala?Ser?Thr?Leu?Ala?Arg?Glu?Phe?Asp?Asp?Val

145 150 155 160

Asp?Arg?Leu?Ala?Thr?Phe?Phe?Asp?Leu?Val?Gln?Gln?Asp?Pro?Val?Val

165 170 175

Ser?Gln?Val?Lys?Leu?Ile?Ala?Glu?Pro?Trp?Asp?Val?Gly?Glu?Gly?Gly

180 185 190

Tyr?Gln?Val?Gly?Asn?Phe?Pro?Pro?Leu?Trp?Thr?Glu?Trp?Asn?Gly?Lys

195 200 205

Tyr?Arg?Asp?Thr?Val?Arg?Asp?Phe?Trp?Arg?Gly?Glu?Pro?Ala?Thr?Leu

210 215 220

Gly?Glu?Phe?Ala?Ser?Arg?Leu?Thr?Gly?Ser?Ser?Asp?Leu?Tyr?Ala?Asn

225 230 235 240

Asn?Gly?Arg?Arg?Pro?Thr?Ala?Ser?Ile?Asn?Phe?Val?Thr?Ala?His?Asp

245 250 255

Gly?Phe?Thr?Leu?Asn?Asp?Leu?Val?Ser?Tyr?Asn?Glu?Lys?His?Asn?Met

260 265 270

Ala?Asn?Gly?Glu?Asp?Gly?Arg?Asp?Gly?Glu?Ser?His?Asn?Arg?Ser?Trp

275 280 285

Asn?Cys?Gly?Val?Glu?Gly?Pro?Thr?Asp?Asp?Pro?Glu?Ile?Met?Gln?Leu

290 295 300

Arg?Ala?Gln?Gln?Arg?Arg?Asn?Phe?Leu?Thr?Thr?Leu?Leu?Leu?Ser?Gln

305 310 315 320

Gly?Thr?Pro?Met?Leu?Ser?His?Gly?Asp?Glu?Met?Ala?Arg?Thr?Gln?Asn

325 330 335

Gly?Asn?Asn?Asn?Val?Tyr?Cys?Gln?Asp?Asn?Glu?Leu?Ala?Trp?Val?Asn

340 345 350

Trp?Asp?Gln?Ala?Glu?Glu?Asn?Ala?Asp?Leu?Val?Ser?Phe?Thr?Arg?Arg

355 360 365

Leu?Leu?Arg?Ile?Arg?Ala?Asn?His?Pro?Val?Phe?Arg?Arg?Arg?Gln?Phe

370 375 380

Leu?Ala?Gly?Gly?Pro?Leu?Gly?Ala?Asp?Val?Arg?Asp?Arg?Asp?Ile?Ala

385 390 395 400

Trp?Leu?Val?Pro?Asn?Gly?Thr?Leu?Met?Thr?Gln?Asp?Asp?Trp?Asp?Phe

405 410 415

Ala?Phe?Gly?Lys?Ser?Leu?Gln?Val?Phe?Phe?Asn?Gly?Asp?Ala?Ile?Glu

420 425 430

Glu?Pro?Asp?Tyr?Arg?Gly?Gln?Lys?Ile?His?Asp?Asp?Ser?Phe?Ile?Leu

435 440 445

Met?Phe?Asn?Ala?His?Phe?Glu?Pro?Ile?Asp?Phe?Asn?Leu?Pro?Pro?Glu

450 455 460

His?Phe?Gly?Met?Lys?Trp?Lys?Leu?Leu?Val?Asp?Thr?Thr?Glu?Ala?Val

465 470 475 480

Gly?His?Pro?Leu?Glu?Asp?Leu?Thr?Ile?Glu?Ala?Gly?Gly?Thr?Ile?Thr

485 490 495

Val?Pro?Ala?Arg?Ser?Thr?Met?Leu?Leu?Arg?Gln?Val?Glu?Ala?Pro?Asp

500 505 510

Tyr?Thr?Lys?Leu?Glu?Glu?Lys?Ile?Ala?Ala?Glu?Lys?Arg?Glu?Gln?Glu

515 520 525

Leu?Ala?Ala?Glu?Lys?Glu?Ala?Ala?Glu?Lys?Arg?Glu?Leu?Glu?Leu?Ala

530 535 540

Ala?Ala?Lys?Glu?Ala?Glu?Asp?Ala?Ala?Glu?Ala?Leu?His?Leu?Ala?Ala

545 550 555 560

Glu?Arg?Ala?Ser?Thr?Gln?Glu?Ala?Glu?Leu?Ala?His?Gln?His?Gly?Ala

565 570 575

Asp?Ala?Ile?Ala?Asp?Glu?Val?Ala?Glu?Glu?Pro?Gln?Glu?Leu?Pro?Gln

580 585 590

Asp?Glu?Val?Ala?Ala?Glu?Val?Glu?Thr?Glu?Pro?Asp?Thr?Glu?Pro?Asp

595 600 605

Thr?Glu?Ser?Asp?Ser?Glu?Gln?Ala?Glu?Val?Ala?Ser?Glu?Glu?Pro?Glu

610 615 620

Ala?Asp?Glu?Glu?Glu?Lys

625 630

<210>365

<211>1496

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(1473)

<223>FRXA01884

<400>365

atg?cat?gtc?gac?ggc?ttc?cgc?ttc?gac?ctt?gcc?tct?acc?ctt?gct?cgt 48

Met?His?Val?Asp?Gly?Phe?Arg?Phe?Asp?Leu?Ala?Ser?Thr?Leu?Ala?Arg

1 5 10 15

gaa?ttt?gat?gat?gtt?gac?cgc?ctg?gca?acc?ttc?ttc?gac?ctg?gtc?caa 96

Glu?Phe?Asp?Asp?Val?Asp?Arg?Leu?Ala?Thr?Phe?Phe?Asp?Leu?Val?Gln

20 25 30

caa?gac?ccg?gtg?gtc?tcc?cag?gtc?aag?ctc?att?gct?gag?ccg?tgg?gat 144

Gln?Asp?Pro?Val?Val?Ser?Gln?Val?Lys?Leu?Ile?Ala?Glu?Pro?Trp?Asp

35 40 45

gtt?ggc?gaa?ggc?gga?tac?caa?gtg?ggt?aac?ttc?cca?cca?ctg?tgg?act 192

Val?Gly?Glu?Gly?Gly?Tyr?Gln?Val?Gly?Asn?Phe?Pro?Pro?Leu?Trp?Thr

50 55 60

gag?tgg?aac?ggt?aaa?tac?cgc?gac?act?gtc?cgt?gat?ttc?tgg?cgt?ggt 240

Glu?Trp?Asn?Gly?Lys?Tyr?Arg?Asp?Thr?Val?Arg?Asp?Phe?Trp?Arg?Gly

65 70 75 80

gag?cca?gca?acc?ttg?ggt?gaa?ttc?gct?tcc?cga?cta?act?ggt?tcc?tct 288

Glu?Pro?Ala?Thr?Leu?Gly?Glu?Phe?Ala?Ser?Arg?Leu?Thr?Gly?Ser?Ser

85 90 95

gat?ttg?tat?gca?aac?aac?ggc?cgt?cgc?ccc?act?gca?tcg?atc?aac?ttt 336

Asp?Leu?Tyr?Ala?Asn?Asn?Gly?Arg?Arg?Pro?Thr?Ala?Ser?Ile?Asn?Phe

100 105 110

gtg?act?gct?cac?gac?ggc?ttc?acc?ctc?aat?gac?ttg?gtc?agt?tac?aac 384

Val?Thr?Ala?His?Asp?Gly?Phe?Thr?Leu?Asn?Asp?Leu?Val?Ser?Tyr?Asn

115 120 125

gag?aag?cac?aac?atg?gcc?aac?ggt?gaa?gac?ggt?cgg?gac?ggt?gaa?tca 432

Glu?Lys?His?Asn?Met?Ala?Asn?Gly?Glu?Asp?Gly?Arg?Asp?Gly?Glu?Ser

130 135 140

cac?aac?cgt?tcc?tgg?aac?tgt?ggc?gtc?gaa?gga?cca?act?gac?gat?cct 480

His?Asn?Arg?Ser?Trp?Asn?Cys?Gly?Val?Glu?Gly?Pro?Thr?Asp?Asp?Pro

145 150 155 160

gag?att?atg?cag?ctg?cgt?gct?cag?caa?cga?cgc?aac?ttc?ctc?acc?acc 528

Glu?Ile?Met?Gln?Leu?Arg?Ala?Gln?Gln?Arg?Arg?Asn?Phe?Leu?Thr?Thr

165 170 175

ttg?ttg?ctg?tcc?cag?ggc?acc?cct?atg?ttg?tcc?cac?ggt?gat?gaa?atg 576

Leu?Leu?Leu?Ser?Gln?Gly?Thr?Pro?Met?Leu?Ser?His?Gly?Asp?Glu?Met

180 185 190

gcc?cgt?acc?caa?aac?ggc?aac?aac?aac?gtc?tac?tgc?caa?gac?aat?gaa 624

Ala?Arg?Thr?Gln?Asn?Gly?Asn?Asn?Asn?Val?Tyr?Cys?Gln?Asp?Asn?Glu

195 200 205

ctg?gcg?tgg?gtg?aat?tgg?gat?cag?gct?gaa?gaa?aac?gct?gac?ttg?gtg 672

Leu?Ala?Trp?Val?Asn?Trp?Asp?Gln?Ala?Glu?Glu?Asn?Ala?Asp?Leu?Val

210 215 220

agc?ttc?acc?agg?cgt?ttg?ctg?cgt?atc?cga?gca?aac?cac?cca?gta?ttt 720

Ser?Phe?Thr?Arg?Arg?Leu?Leu?Arg?Ile?Arg?Ala?Asn?His?Pro?Val?Phe

225 230 235 240

agg?cgc?agg?cag?ttc?ctt?gcc?ggt?ggc?cct?ttg?ggc?gcc?gat?gtt?cgt 768

Arg?Arg?Arg?Gln?Phe?Leu?Ala?Gly?Gly?Pro?Leu?Gly?Ala?Asp?Val?Arg

245 250 255

gac?cgc?gat?atc?gca?tgg?ctg?gta?cca?aat?gga?acc?ttg?atg?act?caa 816

Asp?Arg?Asp?Ile?Ala?Trp?Leu?Val?Pro?Asn?Gly?Thr?Leu?Met?Thr?Gln

260 265 270

gat?gac?tgg?gac?ttc?gct?ttc?ggt?aaa?tca?ctg?cag?gtg?ttc?ttc?aac 864

Asp?Asp?Trp?Asp?Phe?Ala?Phe?Gly?gys?Ser?Leu?Gln?Val?Phe?Phe?Asn

275 280 285

ggc?gat?gcc?atc?gaa?gag?cct?gat?tat?cga?gga?cag?aaa?atc?cac?gat 912

Gly?Asp?Ala?Ile?Glu?Glu?Pro?Asp?Tyr?Arg?Gly?Gln?Lys?Ile?His?Asp

290 295 300

gac?tcc?ttc?atc?ttg?atg?ttc?aac?gct?cac?ttc?gaa?cct?atc?gat?ttc 960

Asp?Ser?Phe?Ile?Leu?Met?Phe?Asn?Ala?His?Phe?Glu?Pro?Ile?Asp?Phe

305 310 315 320

aat?ctc?cct?cct?gag?cat?ttc?ggt?atg?aag?tgg?aag?ctt?ttg?gtc?gat 1008

Asn?Leu?Pro?Pro?Glu?His?Phe?Gly?Met?Lys?Trp?Lys?Leu?Leu?Val?Asp

325 330 335

acc?acc?gaa?gcg?gtg?ggc?cac?ccg?ctg?gag?gat?ctc?acc?atc?gaa?gct 1056

Thr?Thr?Glu?Ala?Val?Gly?His?Pro?Leu?Glu?Asp?Leu?Thr?Ile?Glu?Ala

340 345 350

ggc?gga?acc?atc?act?gtt?cct?gcc?cgt?tcc?acg?atg?ctg?ctg?cgc?cag 1104

Gly?Gly?Thr?Ile?Thr?Val?Pro?Ala?Arg?Ser?Thr?Met?Leu?Leu?Arg?Gln

355 360 365

gtg?gag?gct?ccg?gac?tac?acc?aag?ctt?gag?gaa?aag?atc?gct?gct?gaa 1152

Val?Glu?Ala?Pro?Asp?Tyr?Thr?Lys?Leu?Glu?Glu?Lys?Ile?Ala?Ala?Glu

370 375 380

aag?cgt?gag?caa?gaa?ctt?gcg?gca?gag?aag?gaa?gct?gct?gag?aag?cgc 1200

Lys?Arg?Glu?Gln?Glu?Leu?Ala?Ala?Glu?Lys?Glu?Ala?Ala?Glu?Lys?Arg

385 390 395 400

gaa?ttg?gaa?ctg?gcg?gca?gca?aag?gaa?gct?gaa?gat?gct?gct?gag?gct 1248

Glu?Leu?Glu?Leu?Ala?Ala?Ala?Lys?Glu?Ala?Glu?Asp?Ala?Ala?Glu?Ala

405 410 415

ctc?cac?ctt?gcg?gca?gaa?cgt?gct?tcg?act?cag?gaa?gct?gaa?ttg?gcc 1296

Leu?His?Leu?Ala?Ala?Glu?Arg?Ala?Ser?Thr?Gln?Glu?Ala?Glu?Leu?Ala

420 425 430

cat?caa?cac?ggt?gct?gat?gcg?att?gcc?gat?gag?gta?gcg?gaa?gaa?cca 1344

His?Gln?His?Gly?Ala?Asp?Ala?Ile?Ala?Asp?Glu?Val?Ala?Glu?Glu?Pro

435 440 445

caa?gag?ctg?cca?caa?gat?gaa?gta?gcg?gca?gag?gtc?gag?act?gag?ccc 1392

Gln?Glu?Leu?Pro?Gln?Asp?Glu?Val?Ala?Ala?Glu?Val?Glu?Thr?Glu?Pro

450 455 460

gac?acc?gag?cct?gac?act?gaa?tct?gac?tcc?gag?cag?gct?gag?gta?gct 1440

Asp?Thr?Glu?Pro?Asp?Thr?Glu?Ser?Asp?Ser?Glu?Gln?Ala?Glu?Val?Ala

465 470 475 480

tca?gag?gag?cct?gaa?gcg?gac?gaa?gaa?gag?aag?tagtacaccg?aaagtggcgt?1493

Ser?Glu?Glu?Pro?Glu?Ala?Asp?Glu?Glu?Glu?Lys

485 490

cgc 1496

<210>366

<211>491

<212>PRT

＜213〉Corynebacterium glutamicum

<400>366

Met?His?Val?Asp?Gly?Phe?Arg?Phe?Asp?Leu?Ala?Ser?Thr?Leu?Ala?Arg

1 5 10 15

Glu?Phe?Asp?Asp?Val?Asp?Arg?Leu?Ala?Thr?Phe?Phe?Asp?Leu?Val?Gln

20 25 30

Gln?Asp?Pro?Val?Val?Ser?Gln?Val?Lys?Leu?Ile?Ala?Glu?Pro?Trp?Asp

35 40 45

Val?Gly?Glu?Gly?Gly?Tyr?Gln?Val?Gly?Asn?Phe?Pro?Pro?Leu?Trp?Thr

50 55 60

Glu?Trp?Asn?Gly?Lys?Tyr?Arg?Asp?Thr?Val?Arg?Asp?Phe?Trp?Arg?Gly

65 70 75 80

Glu?Pro?Ala?Thr?Leu?Gly?Glu?Phe?Ala?Ser?Arg?Leu?Thr?Gly?Ser?Ser

85 90 95

Asp?Leu?Tyr?Ala?Asn?Asn?Gly?Arg?Arg?Pro?Thr?Ala?Ser?Ile?Asn?Phe

100 105 110

Val?Thr?Ala?His?Asp?Gly?Phe?Thr?Leu?Asn?Asp?Leu?Val?Ser?Tyr?Asn

115 120 125

Glu?Lys?His?Asn?Met?Ala?Asn?Gly?Glu?Asp?Gly?Arg?Asp?Gly?Glu?Ser

130 135 140

His?Asn?Arg?Ser?Trp?Asn?Cys?Gly?Val?Glu?Gly?Pro?Thr?Asp?Asp?Pro

145 150 155 160

Glu?Ile?Met?Gln?Leu?Arg?Ala?Gln?Gln?Arg?Arg?Asn?Phe?Leu?Thr?Thr

165 170 175

Leu?Leu?Leu?Ser?Gln?Gly?Thr?Pro?Met?Leu?Ser?His?Gly?Asp?Glu?Met

180 185 190

Ala?Arg?Thr?Gln?Asn?Gly?Asn?Asn?Asn?Val?Tyr?Cys?Gln?Asp?Asn?Glu

195 200 205

Leu?Ala?Trp?Val?Asn?Trp?Asp?Gln?Ala?Glu?Glu?Asn?Ala?Asp?Leu?Val

210 215 220

Ser?Phe?Thr?Arg?Arg?Leu?Leu?Arg?Ile?Arg?Ala?Asn?His?Pro?Val?Phe

225 230 235 240

Arg?Arg?Arg?Gln?Phe?Leu?Ala?Gly?Gly?Pro?Leu?Gly?Ala?Asp?Val?Arg

245 250 255

Asp?Arg?Asp?Ile?Ala?Trp?Leu?Val?Pro?Asn?Gly?Thr?Leu?Met?Thr?Gln

260 265 270

Asp?Asp?Trp?Asp?Phe?Ala?Phe?Gly?Lys?Ser?Leu?Gln?Val?Phe?Phe?Asn

275 280 285

Gly?Asp?Ala?Ile?Glu?Glu?Pro?Asp?Tyr?Arg?Gly?Gln?Lys?Ile?His?Asp

290 295 300

Asp?Ser?Phe?Ile?Leu?Met?Phe?ASn?Ala?His?Phe?Glu?Pro?Ile?Asp?Phe

305 310 315 320

Asn?Leu?Pro?Pro?Glu?His?Phe?Gly?Met?Lys?Trp?Lys?Leu?Leu?Val?Asp

325 330 335

Thr?Thr?Glu?Ala?Val?Gly?His?Pro?Leu?Glu?Asp?Leu?Thr?Ile?Glu?Ala

340 345 350

Gly?Gly?Thr?Ile?Thr?Val?Pro?Ala?Arg?Ser?Thr?Met?Leu?Leu?Arg?Gln

355 360 365

Val?Glu?Ala?Pro?Asp?Tyr?Thr?Lys?Leu?Glu?Glu?Lys?Ile?Ala?Ala?Glu

370 375 380

Lys?Arg?Glu?Gln?Glu?Leu?Ala?Ala?Glu?Lys?Glu?Ala?Ala?Glu?Lys?Arg

385 390 395 400

Glu?Leu?Glu?Leu?Ala?Ala?Ala?Lys?Glu?Ala?Glu?Asp?Ala?Ala?Glu?Ala

405 410 415

Leu?His?Leu?Ala?Ala?Glu?Arg?Ala?Ser?Thr?Gln?Glu?Ala?Glu?Leu?Ala

420 425 430

His?Gln?His?Gly?Ala?Asp?Ala?Ile?Ala?Asp?Glu?Val?Ala?Glu?Glu?Pro

435 440 445

Gln?Glu?Leu?Pro?Gln?Asp?Glu?Val?Ala?Ala?Glu?Val?Glu?Thr?Glu?Pro

450 455 460

Asp?Thr?Glu?Pro?Asp?Thr?Glu?Ser?Asp?Ser?Glu?Gln?Ala?Glu?Val?Ala

465 470 475 480

Ser?Glu?Glu?Pro?Glu?Ala?Asp?Glu?Glu?Glu?Lys

485 490

<210>367

<211>547

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(547)

<223>RXA01111

<400>367

agaaaaccct?gccgatgcaa?actttgagga?gagattcaat?caaggaatag?aaatcattct?60

ggtgggtcta?gacgcgcttg?ggcatataag?atgacgttcc?atg?aca?tca?acg?att 115

Met?Thr?Ser?Thr?Ile

1 5

gag?cac?tcg?tac?caa?gtt?tgg?cct?gga?cat?gct?tat?cct?ctg?ggt?tca 163

Glu?His?Ser?Tyr?Gln?Val?Trp?Pro?Gly?His?Ala?Tyr?Pro?Leu?Gly?Ser

10 15 20

acc?tat?gac?ggt?gct?gga?acg?aac?ttc?gca?ctc?ttc?tcc?gac?gtt?gca 211

Thr?Tyr?Asp?Gly?Ala?Gly?Thr?Asn?Phe?Ala?Leu?Phe?Ser?Asp?Val?Ala

25 30 35

gag?cgt?gtt?gag?ctg?tgt?cta?tta?gat?gca?gat?aac?aac?gag?act?cga 259

Glu?Arg?Val?Glu?Leu?Cys?Leu?Leu?Asp?Ala?Asp?Asn?Asn?Glu?Thr?Arg

40 45 50

att?cca?ctc?gaa?gag?cgc?gat?gcc?cac?att?tgg?cat?tgc?tac?ctt?cct 307

Ile?Pro?Leu?Glu?Glu?Arg?Asp?Ala?His?Ile?Trp?His?Cys?Tyr?Leu?Pro

55 60 65

ggc?gtt?caa?cct?gga?cag?cgc?tac?gga?ttc?cga?gtt?cat?ggc?ccg?tgg 355

Gly?Val?Gln?Pro?Gly?Gln?Arg?Tyr?Gly?Phe?Arg?Val?His?Gly?Pro?Trp

70 75 80 85

aac?cca?gat?gag?ggt?aag?cgg?tgc?gac?gcg?aac?aaa?ctt?cta?gtt?gat 403

Asn?Pro?Asp?Glu?Gly?Lys?Arg?Cys?Asp?Ala?Asn?Lys?Leu?Leu?Val?Asp

90 95 100

ccc?tat?gct?cgt?gct?ttc?gat?gga?gat?ttt?gat?gga?cat?ccg?tca?cta 451

Pro?Tyr?Ala?Arg?Ala?Phe?Asp?Gly?Asp?Phe?Asp?Gly?His?Pro?Ser?Leu

105 110 115

ttt?tct?tac?gac?atc?acc?aat?cca?aat?gac?ccc?aac?ggt?cgc?aat?acc 499

Phe?Ser?Tyr?Asp?Ile?Thr?Asn?Pro?Asn?Asp?Pro?Asn?Gly?Arg?Asn?Thr

120 125 130

gaa?gac?agc?att?gat?cac?aca?atg?aag?tct?gtc?gtg?gtg?aac?cca?ttc 547

Glu?Asp?Ser?Ile?Asp?His?Thr?Met?Lys?Ser?Val?Val?Val?Asn?Pro?Phe

135 140 145

<210>368

<21l>149

<212>PRT

＜213〉Corynebacterium glutamicum

<400>368

Met?Thr?Ser?Thr?Ile?Glu?His?Ser?Tyr?Gln?Val?Trp?Pro?Gly?His?Ala

1 5 10 15

Tyr?Pro?Leu?Gly?Ser?Thr?Tyr?Asp?Gly?Ala?Gly?Thr?Asn?Phe?Ala?Leu

20 25 30

Phe?Ser?Asp?Val?Ala?Glu?Arg?Val?Glu?Leu?Cys?Leu?Leu?Asp?Ala?Asp

35 40 45

Asn?Asn?Glu?Thr?Arg?Ile?Pro?Leu?Glu?Glu?Arg?Asp?Ala?His?Ile?Trp

50 55 60

His?Cys?Tyr?Leu?Pro?Gly?Val?Gln?Pro?Gly?Gln?Arg?Tyr?Gly?Phe?Arg

65 70 75 80

Val?His?Gly?Pro?Trp?Asn?Pro?Asp?Glu?Gly?Lys?Arg?Cys?Asp?Ala?Asn

85 90 95

Lys?Leu?Leu?Val?Asp?Pro?Tyr?Ala?Arg?Ala?Phe?Asp?Gly?Asp?Phe?Asp

100 105 110

Gly?His?Pro?Ser?Leu?Phe?Ser?Tyr?Asp?Ile?Thr?Asn?Pro?Asn?Asp?Pro

115 120 125

Asn?Gly?Arg?Asn?Thr?Glu?Asp?Ser?Ile?Asp?His?Thr?Met?Lys?Ser?Val

130 135 140

Val?Val?Asn?Pro?Phe

145

<210>369

<211>1635

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1612)

<223>RXN01550

<400>369

ttcgccagca?gtacttcttc?acctctgctt?ccctgcaggc?catgattcag?ggccacctgg?60

cgcaccacaa?ggacctcagc?aactttgccg?agttcactcc?gtg?cag?ctc?aat?gac 115

Val?Gln?Leu?Asn?Asp

1 5

act?cac?cca?gtg?ttg?gct?atc?cct?gag?ctt?atg?cgt?ctg?ctc?atg?gac 163

Thr?His?Pro?Val?Leu?Ala?Ile?Pro?Glu?Leu?Met?Arg?Leu?Leu?Met?Asp

10 15 20

gag?cat?gac?atg?ggc?tgg?gaa?gaa?tcc?tgg?gca?atc?gtg?ttc?aag?acc 211

Glu?His?Asp?Met?Gly?Trp?Glu?Glu?Ser?Trp?Ala?Ile?Val?Phe?Lys?Thr

25 30 35

ttc?gca?tac?acc?aac?cac?acc?gtg?ctc?acc?gaa?gct?ctt?gag?cag?tgg 259

Phe?Ala?Tyr?Thr?Asn?His?Thr?Val?Leu?Thr?Glu?Ala?Leu?Glu?Gln?Trp

40 45 50

gat?cag?cag?atc?ttc?caa?cag?ctg?ttc?tgg?cgc?gtg?tgg?gaa?atc?atc 307

Asp?Gln?Gln?Ile?Phe?Gln?Gln?Leu?Phe?Trp?Arg?Val?Trp?Glu?Ile?Ile

55 60 65

aca?gag?atc?gat?cgc?cgc?ttc?cgt?ttg?gag?cgc?gca?gcc?gat?gga?ctg 355

Thr?Glu?Ile?Asp?Arg?Arg?Phe?Arg?Leu?Glu?Arg?Ala?Ala?Asp?Gly?Leu

70 75 80 85

gat?gaa?gag?acc?atc?gac?cgc?atg?gct?cca?atc?cag?cac?ggc?act?gtt 403

Asp?Glu?Glu?Thr?Ile?Asp?Arg?Met?Ala?Pro?Ile?Gln?His?Gly?Thr?Val

90 95 100

cat?atg?gca?tgg?att?gcc?tgt?tac?gcg?gca?tat?tcc?atc?aat?ggc?gtg 451

His?Met?Ala?Trp?Ile?Ala?Cys?Tyr?Ala?Ala?Tyr?Ser?Ile?Asn?Gly?Val

105 110 115

gca?gcg?ctg?cac?acc?gag?atc?atc?aag?gcc?gag?acc?ttg?gct?gac?tgg 499

Ala?Ala?Leu?His?Thr?Glu?Ile?Ile?Lys?Ala?Glu?Thr?Leu?Ala?Asp?Trp

120 125 130

tac?gca?ctg?tgg?cca?gag?aag?ttc?aac?aac?aag?act?aac?ggt?gtt?acc 547

Tyr?Ala?Leu?Trp?Pro?Glu?Lys?Phe?Asn?Asn?Lys?Thr?Asn?Gly?Val?Thr

135 140 145

cca?cgc?cgt?tgg?ctg?cgc?atg?atc?aac?cca?ggt?ctg?tct?gac?ctg?ctc 595

Pro?Arg?Arg?Trp?Leu?Arg?Met?Ile?Asn?Pro?Gly?Leu?Ser?Asp?Leu?Leu

150 155 160 165

act?cga?ctt?tcc?ggt?tcc?gat?gat?tgg?gta?acc?gat?ctg?gat?gag?ctg 643

Thr?Arg?Leu?Ser?Gly?Ser?Asp?Asp?Trp?Val?Thr?Asp?Leu?Asp?Glu?Leu

170 175 180

aag?aag?ctg?cgc?tcc?tat?gcc?gac?gat?aag?tcc?gtg?ctt?gaa?gaa?ctc 691

Lys?Lys?Leu?Arg?Ser?Tyr?Ala?Asp?Asp?Lys?Ser?Val?Leu?Glu?Glu?Leu

185 190 195

cgc?gct?atc?aag?gct?gct?aat?aag?caa?gac?ttc?gcc?gag?tgg?atc?ctc 739

Arg?Ala?Ile?Lys?Ala?Ala?Asn?Lys?Gln?Asp?Phe?Ala?Glu?Trp?Ile?Leu

200 205 210

gag?cgc?cag?ggc?att?gag?att?gat?cca?gaa?tcc?atc?ttt?gac?gtg?cag 787

Glu?Arg?Gln?Gly?Ile?Glu?Ile?Asp?Pro?Glu?Ser?Ile?Phe?Asp?Val?Gln

215 220 225

att?aag?cgc?ctc?cac?gag?tac?aag?cgc?cag?ctc?atg?aac?gcg?ctc?tac 835

Ile?Lys?Arg?Leu?His?Glu?Tyr?Lys?Arg?Gln?Leu?Met?Asn?Ala?Leu?Tyr

230 235 240 245

gta?cta?gac?ctt?tac?ttc?cgt?att?aag?gaa?gat?ggc?ctc?acc?gac?atc 883

Val?Leu?Asp?Leu?Tyr?Phe?Arg?Ile?Lys?Glu?Asp?Gly?Leu?Thr?Asp?Ile

250 255 260

cca?gca?cgc?act?gtc?atc?ttt?ggc?gcc?aag?gcc?gcg?ccg?ggt?tat?gtc 931

Pro?Ala?Arg?Thr?Val?Ile?Phe?Gly?Ala?Lys?Ala?Ala?Pro?Gly?Tyr?Val

265 270 275

cgc?gcc?aag?gcg?att?atc?aag?ctc?atc?aac?tct?att?gct?gac?ttg?gta 979

Arg?Ala?Lys?Ala?Ile?Ile?Lys?Leu?Ile?Asn?Ser?Ile?Ala?Asp?Leu?Val

280 285 290

aac?aac?gat?cct?gag?gtc?tcc?ccg?ctg?ctc?aag?gtg?gtc?ttt?gta?gag 1027

Asn?Asn?Asp?Pro?Glu?Val?Ser?Pro?Leu?Leu?Lys?Val?Val?Phe?Val?Glu

295 300 305

aac?tac?aac?gtc?tcc?cct?gct?gag?cac?atc?ttg?cct?gcg?tct?gat?gtc 1075

Asn?Tyr?Asn?Val?Ser?Pro?Ala?Glu?His?Ile?Leu?Pro?Ala?Ser?Asp?Val

310 315 320 325

tcc?gaa?cag?att?tcc?acc?gcc?ggc?aag?gaa?gcc?agc?ggt?acc?tcc?aac 1123

Ser?Glu?Gln?Ile?Ser?Thr?Ala?Gly?Lys?Glu?Ala?Ser?Gly?Thr?Ser?Asn

330 335 340

atg?aag?ttc?atg?atg?aac?ggc?gcc?ctc?acc?ctg?ggc?acc?atg?gac?ggc 1171

Met?Lys?Phe?Met?Met?Asn?Gly?Ala?Leu?Thr?Leu?Gly?Thr?Met?Asp?Gly

345 350 355

gcc?aac?gta?gag?atc?gtg?gat?tct?gtg?ggc?gag?gaa?aac?gcc?tat?atc 1219

Ala?Asn?Val?Glu?Ile?Val?Asp?Ser?Val?Gly?Glu?Glu?Asn?Ala?Tyr?Ile

360 365 370

ttc?ggt?gct?cgc?gtg?gaa?gaa?ttg?cca?gcc?ctg?cgc?gaa?agc?tac?gag 1267

Phe?Gly?Ala?Arg?Val?Glu?Glu?Leu?Pro?Ala?Leu?Arg?Glu?Ser?Tyr?Glu

375 380 385

cca?tat?gag?ctc?tat?gag?acc?gtc?cct?ggc?ctc?aag?cgc?gca?ttg?gac 1315

Pro?Tyr?Glu?Leu?Tyr?Glu?Thr?Val?Pro?Gly?Leu?Lys?Arg?Ala?Leu?Asp

390 395 400 405

gcc?ctg?gat?aac?ggc?acc?ctc?aac?gac?aac?aac?agt?ggt?ttg?ttc?tac 1363

Ala?Leu?Asp?Asn?Gly?Thr?Leu?Asn?Asp?Asn?Asn?Ser?Gly?Leu?Phe?Tyr

410 415 420

gac?ctc?aag?cat?tcc?ttg?atc?cac?ggt?tat?gga?aaa?gac?gcc?agc?gac 1411

Asp?Leu?Lys?His?Ser?Leu?Ile?His?Gly?Tyr?Gly?Lys?Asp?Ala?Ser?Asp

425 430 435

acc?tac?tac?gtg?ctt?ggc?gat?ttc?gca?gat?tac?cgc?gag?acc?cgc?gac 1459

Thr?Tyr?Tyr?Val?Leu?Gly?Asp?Phe?Ala?Asp?Tyr?Arg?Glu?Thr?Arg?Asp

440 445 450

cgt?atg?gcc?gcc?gac?tac?gcc?tcc?gat?ccc?ctg?ggt?tgg?gca?cgc?atg 1507

Arg?Met?Ala?Ala?Asp?Tyr?Ala?Ser?Asp?Pro?Leu?Gly?Trp?Ala?Arg?Met

455 460 465

gcc?tgg?atc?aac?att?tgc?gag?tcc?ggc?cgt?ttc?tcc?tcc?gac?cgc?acc 1555

Ala?Trp?Ile?Asn?Ile?Cys?Glu?Ser?Gly?Arg?Phe?Ser?Ser?Asp?Arg?Thr

470 475 480 485

atc?cgc?gat?tat?gcc?acc?gag?atc?tgg?aag?ctc?gag?cca?act?cct?gct 1603

Ile?Arg?Asp?Tyr?Ala?Thr?Glu?Ile?Trp?Lys?Leu?Glu?Pro?Thr?Pro?Ala

490 495 500

gtt?aag?aag?taggttttaa?cctccgcttc?taa 1635

Val?Lys?Lys

<210>370

<211>504

<212>PRT

＜213〉Corynebacterium glutamicum

<400>370

Val?Gln?Leu?Asn?Asp?Thr?His?Pro?Val?Leu?Ala?Ile?Pro?Glu?Leu?Met

1 5 10 15

Arg?Leu?Leu?Met?Asp?Glu?His?Asp?Met?Gly?Trp?Glu?Glu?Ser?Trp?Ala

20 25 30

Ile?Val?Phe?Lys?Thr?Phe?Ala?Tyr?Thr?Asn?His?Thr?Val?Leu?Thr?Glu

35 40 45

Ala?Leu?Glu?Gln?Trp?Asp?Gln?Gln?Ile?Phe?Gln?Gln?Leu?Phe?Trp?Arg

50 55 60

Val?Trp?Glu?Ile?Ile?Thr?Glu?Ile?Asp?Arg?Arg?Phe?Arg?Leu?Glu?Arg

65 70 75 80

Ala?Ala?Asp?Gly?Leu?Asp?Glu?Glu?Thr?Ile?Asp?Arg?Met?Ala?Pro?Ile

85 90 95

Gln?His?Gly?Thr?Val?His?Met?Ala?Trp?Ile?Ala?Cys?Tyr?Ala?Ala?Tyr

100 105 110

Ser?Ile?Asn?Gly?Val?Ala?Ala?Leu?His?Thr?Glu?Ile?Ile?Lys?Ala?Glu

115 120 125

Thr?Leu?Ala?Asp?Trp?Tyr?Ala?Leu?Trp?Pro?Glu?Lys?Phe?Asn?Asn?Lys

130 135 140

Thr?Ash?Gly?Val?Thr?Pro?Arg?Arg?Trp?Leu?Arg?Met?Ile?Asn?Pro?Gly

145 150 155 160

Leu?Ser?Asp?Leu?Leu?Thr?Arg?Leu?Ser?Gly?Ser?Asp?Asp?Trp?Val?Thr

165 170 175

Asp?Leu?Asp?Glu?Leu?Lys?Lys?Leu?Arg?Ser?Tyr?Ala?Asp?Asp?Lys?Ser

180 185 190

Val?Leu?Glu?Glu?Leu?Arg?Ala?Ile?Lys?Ala?Ala?Asn?Lys?Gln?Asp?Phe

195 200 205

Ala?Glu?Trp?Ile?Leu?Glu?Arg?Gln?Gly?Ile?Glu?Ile?Asp?Pro?Glu?Ser

210 215 220

Ile?Phe?Asp?Val?Gln?Ile?Lys?Arg?Leu?His?Glu?Tyr?Lys?Arg?Gln?Leu

225 230 235 240

Met?Asn?Ala?Leu?Tyr?Val?Leu?Asp?Leu?Tyr?Phe?Arg?Ile?Lys?Glu?Asp

245 250 255

Gly?Leu?Thr?Asp?Ile?Pro?Ala?Arg?Thr?Val?Ile?Phe?Gly?Ala?Lys?Ala

260 265 270

Ala?Pro?Gly?Tyr?Val?Arg?Ala?Lys?Ala?Ile?Ile?Lys?Leu?Ile?Asn?Ser

275 280 285

Ile?Ala?Asp?Leu?Val?Asn?Asn?Asp?Pro?Glu?Val?Ser?Pro?Leu?Leu?Lys

290 295 300

Val?Val?Phe?Val?Glu?Asn?Tyr?Asn?Val?Ser?Pro?Ala?Glu?His?Ile?Leu

305 310 315 320

Pro?Ala?Ser?Asp?Val?Ser?Glu?Gln?Ile?Ser?Thr?Ala?Gly?Lys?Glu?Ala

325 330 335

Ser?Gly?Thr?Ser?Asn?Met?Lys?Phe?Met?Met?Asn?Gly?Ala?Leu?Thr?Leu

340 345 350

Gly?Thr?Met?Asp?Gly?Ala?Asn?Val?Glu?Ile?Val?Asp?Ser?Val?Gly?Glu

355 360 365

Glu?Asn?Ala?Tyr?Ile?Phe?Gly?Ala?Arg?Val?Glu?Glu?Leu?Pro?Ala?Leu

370 375 380

Arg?Glu?Ser?Tyr?Glu?Pro?Tyr?Glu?Leu?Tyr?Glu?Thr?Val?Pro?Gly?Leu

385 390 395 400

Lys?Arg?Ala?Leu?Asp?Ala?Leu?Asp?Asn?Gly?Thr?Leu?Asn?Asp?Asn?Asn

405 410 415

Ser?Gly?Leu?Phe?Tyr?Asp?Leu?Lys?His?Ser?Leu?Ile?His?Gly?Tyr?Gly

420 425 430

Lys?Asp?Ala?Ser?Asp?Thr?Tyr?Tyr?Val?Leu?Gly?Asp?Phe?Ala?Asp?Tyr

435 440 445

Arg?Glu?Thr?Arg?Asp?Arg?Met?Ala?Ala?Asp?Tyr?Ala?Ser?Asp?Pro?Leu

450 455 460

Gly?Trp?Ala?Arg?Met?Ala?Trp?Ile?Asn?Ile?Cys?Glu?Ser?Gly?Arg?Phe

465 470 475 480

Ser?Ser?Asp?Arg?Thr?Ile?Arg?Asp?Tyr?Ala?Thr?Glu?Ile?Trp?Lys?Leu

485 490 495

Glu?Pro?Thr?Pro?Ala?Val?Lys?Lys

500

<210>371

<211>1367

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(1344)

<223>FRXA01550

<400>37l

atc?ttc?caa?cag?ctg?ttc?tgg?cgc?gtg?tgg?gaa?atc?atc?aca?gag?atc 48

Ile?Phe?Gln?Gln?Leu?Phe?Trp?Arg?Val?Trp?Glu?Ile?Ile?Thr?Glu?Ile

1 5 10 15

gat?cgc?cgc?ttc?cgt?ttg?gag?cgc?gca?gcc?gat?gga?ctg?gat?gaa?gag 96

Asp?Arg?Arg?Phe?Arg?Leu?Glu?Arg?Ala?Ala?Asp?Gly?Leu?Asp?Glu?Glu

20 25 30

acc?atc?gac?cgc?atg?gct?cca?atc?cag?cgc?ggc?act?gtt?cat?atg?gca 144

Thr?Ile?Asp?Arg?Met?Ala?Pro?Ile?Gln?Arg?Gly?Thr?Val?His?Met?Ala

35 40 45

tgg?att?gcc?tgt?tac?gcg?gca?tat?tcc?atc?aat?ggc?gtg?gca?gcg?ctg 192

Trp?Ile?Ala?Cys?Tyr?Ala?Ala?Tyr?Ser?Ile?Asn?Gly?Val?Ala?Ala?Leu

50 55 60

cac?acc?gag?atc?atc?aag?gcc?gag?acc?ttg?gct?gac?tgg?tac?gca?ctg 240

His?Thr?Glu?Ile?Ile?Lys?Ala?Glu?Thr?Leu?Ala?Asp?Trp?Tyr?Ala?Leu

65 70 75 80

tgg?cca?gag?aag?ttc?aac?aac?aag?act?aac?ggt?gtt?acc?cca?cgc?cgt 288

Trp?Pro?Glu?Lys?Phe?Asn?Asn?Lys?Thr?Asn?Gly?Val?Thr?Pro?Arg?Arg

85 90 95

tgg?ctg?cgc?atg?atc?aac?cca?ggt?ctg?tct?gac?ctg?ctc?act?cga?ctt 336

Trp?Leu?Arg?Met?Ile?Asn?Pro?Gly?Leu?Ser?Asp?Leu?Leu?Thr?Arg?Leu

100 105 110

tcc?ggt?tcc?gat?gat?tgg?gta?acc?gat?ctg?gat?gag?ctg?aag?aag?ctg 384

Ser?Gly?Ser?Asp?Asp?Trp?Val?Thr?Asp?Leu?Asp?Glu?Leu?Lys?Lys?Leu

115 120 125

cgc?tcc?tat?gcc?gac?gat?aag?tcc?gtg?ctt?gaa?gaa?ctc?cgc?gct?atc 432

Arg?Ser?Tyr?Ala?Asp?Asp?Lys?Ser?Val?Leu?Glu?Glu?Leu?Arg?Ala?Ile

130 135 140

aag?gct?gct?aat?aag?caa?gac?ttc?gcc?gag?tgg?atc?ctc?gag?cgc?cag 480

Lys?Ala?Ala?Asn?Lys?Gln?Asp?Phe?Ala?Glu?Trp?Ile?Leu?Glu?Arg?Gln

145 150 155 160

ggc?att?gag?att?gat?cca?gaa?tcc?atc?ttt?gac?gtg?cag?att?aag?cgc 528

Gly?Ile?Glu?Ile?Asp?Pro?Glu?Ser?Ile?Phe?Asp?Val?Gln?Ile?Lys?Arg

165 170 175

ctc?cac?gag?tac?aag?cgc?cag?ctc?atg?aac?gcg?ctc?tac?gta?cta?gac 576

Leu?His?Glu?Tyr?Lys?Arg?Gln?Leu?Met?Asn?Ala?Leu?Tyr?Val?Leu?Asp

180 185 190

ctt?tac?ttc?cgt?att?aag?gaa?gat?ggc?ctc?acc?gac?atc?cca?gca?cgc 624

Leu?Tyr?Phe?Arg?Ile?Lys?Glu?Asp?Gly?Leu?Thr?Asp?Ile?Pro?Ala?Arg

195 200 205

act?gtc?atc?ttt?ggc?gcc?aag?gcc?gcg?ccg?ggt?tat?gtc?cgc?gcc?aag 672

Thr?Val?Ile?Phe?Gly?Ala?Lys?Ala?Ala?Pro?Gly?Tyr?Val?Arg?Ala?Lys

210 215 220

gcg?att?atc?aag?ctc?atc?aac?tct?att?gct?gac?ttg?gta?aac?aac?gat 720

Ala?Ile?Ile?Lys?Leu?Ile?Asn?Ser?Ile?Ala?Asp?Leu?Val?Asn?Asn?Asp

225 230 235 240

cct?gag?gtc?tcc?ccg?ctg?ctc?aag?gtg?gtc?ttt?gta?gag?aac?tac?aac 768

Pro?Glu?Val?Ser?Pro?Leu?Leu?Lys?Val?Val?Phe?Val?Glu?Asn?Tyr?Asn

245 250 255

gtc?tcc?cct?gct?gag?cac?atc?ttg?cct?gcg?tct?gat?gtc?tcc?gaa?cag 816

Val?Ser?Pro?Ala?Glu?His?Ile?Leu?Pro?Ala?Ser?Asp?Val?Ser?Glu?Gln

260 265 270

att?tcc?acc?gcc?ggc?aag?gaa?gcc?agc?ggt?acc?tcc?aac?atg?aag?ttc 864

Ile?Ser?Thr?Ala?Gly?Lys?Glu?Ala?Ser?Gly?Thr?Ser?Asn?Met?Lys?Phe

275 280 285

atg?atg?aac?ggc?gcc?ctc?acc?ctg?ggc?acc?atg?gac?ggc?gcc?aac?gta 912

Met?Met?Asn?Gly?Ala?Leu?Thr?Leu?Gly?Thr?Met?Asp?Gly?Ala?Asn?Val

290 295 300

gag?atc?gtg?gat?tct?gtg?ggc?gag?gaa?aac?gcc?tat?atc?ttc?ggt?gct 960

Glu?Ile?Val?Asp?Ser?Val?Gly?Glu?Glu?Asn?Ala?Tyr?Ile?Phe?Gly?Ala

305 310 315 320

cgc?gtg?gaa?gaa?ttg?cca?gcc?ctg?cgc?gaa?agc?tac?gag?cca?tat?gag 1008

Arg?Val?Glu?Glu?Leu?Pro?Ala?Leu?Arg?Glu?Ser?Tyr?Glu?Pro?Tyr?Glu

325 330 335

ctc?tat?gag?acc?gtc?cct?ggc?ctc?aag?cgc?gca?ttg?gac?gcc?ctg?gat 1056

Leu?Tyr?Glu?Thr?Val?Pro?Gly?Leu?Lys?Arg?Ala?Leu?Asp?Ala?Leu?Asp

340 345 350

aac?ggc?acc?ctc?aac?gac?aac?aac?agt?ggt?ttg?ttc?tac?gac?ctc?aag 1104

Asn?Gly?Thr?Leu?Asn?Asp?Asn?Asn?Ser?Gly?Leu?Phe?Tyr?Asp?Leu?Lys

355 360 365

cat?tcc?ttg?atc?cac?ggt?tat?gga?aaa?gac?gcc?agc?gac?acc?tac?tac 1152

His?Ser?Leu?Ile?His?Gly?Tyr?Gly?Lys?Asp?Ala?Ser?Asp?Thr?Tyr?Tyr

370 375 380

gtg?ctt?ggc?gat?ttc?gca?gat?tac?cgc?gag?acc?cgc?gac?cgt?atg?gcc 1200

Val?Leu?Gly?Asp?Phe?Ala?Asp?Tyr?Arg?Glu?Thr?Arg?Asp?Arg?Met?Ala

385 390 395 400

gcc?gac?tac?gcc?tcc?gat?ccc?ctg?ggt?tgg?gca?cgc?atg?gcc?tgg?atc 1248

Ala?Asp?Tyr?Ala?Ser?Asp?Pro?Leu?Gly?Trp?Ala?Arg?Met?Ala?Trp?Ile

405 410 415

aac?att?tgc?gag?tcc?ggc?cgt?ttc?tcc?tcc?gac?cgc?acc?atc?cgc?gat 1296

Asn?Ile?Cys?Glu?Ser?Gly?Arg?Phe?Ser?Ser?Asp?Arg?Thr?Ile?Arg?Asp

420 425 430

tat?gcc?acc?gag?atc?tgg?aag?ctc?gag?cca?act?cct?gct?gtt?aag?aag 1344

Tyr?Ala?Thr?Glu?Ile?Trp?Lys?Leu?Glu?Pro?Thr?Pro?Ala?Val?Lys?Lys

435 440 445

taggttttaa?cctccgcttc?taa 1367

<210>372

<211>448

<212>PRT

＜213〉Corynebacterium glutamicum

<400>372

Ile?Phe?Gln?Gln?Leu?Phe?Trp?Arg?Val?Trp?Glu?Ile?Ile?Thr?Glu?Ile

1 5 10 15

Asp?Arg?Arg?Phe?Arg?Leu?Glu?Arg?Ala?Ala?Asp?Gly?Leu?Asp?Glu?Glu

20 25 30

Thr?Ile?Asp?Arg?Met?Ala?Pro?Ile?Gln?Arg?Gly?Thr?Val?His?Met?Ala

35 40 45

Trp?Ile?Ala?Cys?Tyr?Ala?Ala?Tyr?Ser?Ile?Asn?Gly?Val?Ala?Ala?Leu

50 55 60

His?Thr?Glu?Ile?Ile?Lys?Ala?Glu?Thr?Leu?Ala?Asp?Trp?Tyr?Ala?Leu

65 70 75 80

Trp?Pro?Glu?Lys?Phe?Asn?Asn?Lys?Thr?Asn?Gly?Val?Thr?Pro?Arg?Arg

85 90 95

Trp?Leu?Arg?Met?Ile?Asn?Pro?Gly?Leu?Ser?Asp?Leu?Leu?Thr?Arg?Leu

100 105 110

Ser?Gly?Ser?Asp?Asp?Trp?Val?Thr?Asp?Leu?Asp?Glu?Leu?Lys?Lys?Leu

115 120 125

Arg?Ser?Tyr?Ala?Asp?Asp?Lys?Ser?Val?Leu?Glu?Glu?Leu?Arg?Ala?Ile

130 135 140

Lys?Ala?Ala?Asn?Lys?Gln?Asp?Phe?Ala?Glu?Trp?Ile?Leu?Glu?Arg?Gln

145 150 155 160

Gly?Ile?Glu?Ile?Asp?Pro?Glu?Ser?Ile?Phe?Asp?Val?Gln?Ile?Lys?Arg

165 170 175

Leu?His?Glu?Tyr?Lys?Arg?Gln?Leu?Met?Asn?Ala?Leu?Tyr?Val?Leu?Asp

180 185 190

Leu?Tyr?Phe?Arg?Ile?Lys?Glu?Asp?Gly?Leu?Thr?Asp?Ile?Pro?Ala?Arg

195 200 205

Thr?Val?Ile?Phe?Gly?Ala?Lys?Ala?Ala?Pro?Gly?Tyr?Val?Arg?Ala?Lys

210 215 220

Ala?Ile?Ile?Lys?Leu?Ile?Asn?Ser?Ile?Ala?Asp?Leu?Val?Asn?Asn?Asp

225 230 235 240

Pro?Glu?Val?Ser?Pro?Leu?Leu?Lys?Val?Val?Phe?Val?Glu?Asn?Tyr?Asn

245 250 255

Val?Ser?Pro?Ala?Glu?His?Ile?Leu?Pro?Ala?Ser?Asp?Val?Ser?Glu?Gln

260 265 270

Ile?Ser?Thr?Ala?Gly?Lys?Glu?Ala?Ser?Gly?Thr?Ser?Asn?Met?Lys?Phe

275 280 285

Met?Met?Asn?Gly?Ala?Leu?Thr?Leu?Gly?Thr?Met?Asp?Gly?Ala?Asn?Val

290 295 300

Glu?Ile?Val?Asp?Ser?Val?Gly?Glu?Glu?Asn?Ala?Tyr?Ile?Phe?Gly?Ala

305 310 315 320

Arg?Val?Glu?Glu?Leu?Pro?Ala?Leu?Arg?Glu?Ser?Tyr?Glu?Pro?Tyr?Glu

325 330 335

Leu?Tyr?Glu?Thr?Val?Pro?Gly?Leu?Lys?Arg?Ala?Leu?Asp?Ala?Leu?Asp

340 345 350

Asn?Gly?Thr?Leu?Asn?Asp?Asn?Asn?Ser?Gly?Leu?Phe?Tyr?Asp?Leu?Lys

355 360 365

His?Ser?Leu?Ile?His?Gly?Tyr?Gly?Lys?Asp?Ala?Ser?Asp?Thr?Tyr?Tyr

370 375 380

Val?Leu?Gly?Asp?Phe?Ala?Asp?Tyr?Arg?Glu?Thr?Arg?Asp?Arg?Met?Ala

385 390 395 400

Ala?Asp?Tyr?Ala?Ser?Asp?Pro?Leu?Gly?Trp?Ala?Arg?Met?Ala?Trp?Ile

405 410 415

Asn?Ile?Cys?Glu?Ser?Gly?Arg?Phe?Ser?Ser?Asp?Arg?Thr?Ile?Arg?Asp

420 425 430

Tyr?Ala?Thr?Glu?Ile?Trp?Lys?Leu?Glu?Pro?Thr?Pro?Ala?Val?Lys?Lys

435 440 445

<210>373

<211>2348

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(2325)

<223>RXN02100

<400>373

cta?ggt?cga?atc?aac?gcc?gag?gag?caa?aac?ctc?agc?gaa?tac?ctc?agc 48

Leu?Gly?Arg?Ile?Asn?Ala?Glu?Glu?Gln?Asn?Leu?Ser?Glu?Tyr?Leu?Ser

1 5 10 15

gac?aag?ctg?tgg?tac?cag?gac?acc?gca?gat?gca?acc?gat?gct?gtc?gga 96

Asp?Lys?Leu?Trp?Tyr?Gln?Asp?Thr?Ala?Asp?Ala?Thr?Asp?Ala?Val?Gly

20 25 30

gat?cca?ctc?gtt?gcg?tac?ttc?tcc?atg?gag?ttt?ggc?att?cac?cca?agc 144

Asp?Pro?Leu?Val?Ala?Tyr?Phe?Ser?Met?Glu?Phe?Gly?Ile?His?Pro?Ser

35 40 45

ctg?cca?atc?tac?tct?ggc?gga?ctt?ggt?gtg?ctt?gcg?ggc?gag?aac?atg 192

Leu?Pro?Ile?Tyr?Ser?Gly?Gly?Leu?Gly?Val?Leu?Ala?Gly?Glu?Asn?Met

50 55 60

aag?tct?gca?tct?gac?ttg?ggt?gtg?cca?ctg?atc?ggt?gtt?ggt?ttg?ctc 240

Lys?Ser?Ala?Ser?Asp?Leu?Gly?Val?Pro?Leu?Ile?Gly?Val?Gly?Leu?Leu

65 70 75 80

tac?acc?cac?ggc?tac?ttc?acc?cag?tca?ctg?tcc?ggt?gac?ggt?tgg?cag 288

Tyr?Thr?His?Gly?Tyr?Phe?Thr?Gln?Ser?Leu?Ser?Gly?Asp?Gly?Trp?Gln

85 90 95

cag?gaa?gag?tac?aag?tac?cac?gat?cca?gca?gaa?ctg?ccg?att?gag?gca 336

Gln?Glu?Glu?Tyr?Lys?Tyr?His?Asp?Pro?Ala?Glu?Leu?Pro?Ile?Glu?Ala

100 105 110

gtt?aaa?gat?aag?aac?ggc?gag?cag?gtc?act?gtt?tct?gtc?acc?tac?cca 384

Val?Lys?Asp?Lys?Asn?Gly?Glu?Gln?Val?Thr?Val?Ser?Val?Thr?Tyr?Pro

115 120 125

ggt?gcg?cag?gaa?gta?aag?att?gca?ctg?tgg?gta?gca?aac?gtt?ggc?cgc 432

Gly?Ala?Gln?Glu?Val?Lys?Ile?Ala?Leu?Trp?Val?Ala?Asn?Val?Gly?Arg

130 135 140

atc?cca?ttg?ctg?ctg?ctt?gat?acc?aac?atc?gag?gca?aac?cca?gaa?gag 480

Ile?Pro?Leu?Leu?Leu?Leu?Asp?Thr?Asn?Ile?Glu?Ala?Asn?Pro?Glu?Glu

145 150 155 160

ctc?cgc?aac?gtt?act?gac?cgc?ctg?tac?ggt?ggc?gac?aat?gag?cac?cgc 528

Leu?Arg?Asn?Val?Thr?Asp?Arg?Leu?Tyr?Gly?Gly?Asp?Asn?Glu?His?Arg

165 170 175

atc?aag?cag?gaa?ctc?gtt?ctc?ggt?gtt?ggt?ggc?gtc?cgc?gct?gtc?aac 576

Ile?Lys?Gln?Glu?Leu?Val?Leu?Gly?Val?Gly?Gly?Val?Arg?Ala?Val?Asn

180 185 190

gca?ttc?tgc?gaa?gct?cgt?ggt?ctg?aag?cgc?tca?tct?gtt?gca?cac?ctc 624

Ala?Phe?Cys?Glu?Ala?Arg?Gly?Leu?Lys?Arg?Ser?Ser?Val?Ala?His?Leu

195 200 205

aac?gaa?ggc?cac?gca?ggt?ttc?ctg?acc?ctg?gag?cgt?atc?cgc?gag?cgc 672

Asn?Glu?Gly?His?Ala?Gly?Phe?Leu?Thr?Leu?Glu?Arg?Ile?Arg?Glu?Arg

210 215 220

atc?gca?gag?ggc?atg?gag?tac?cca?gca?gca?ttc?gag?cag?gtt?cgt?gcg 720

Ile?Ala?Glu?Gly?Met?Glu?Tyr?Pro?Ala?Ala?Phe?Glu?Gln?Val?Arg?Ala

225 230 235 240

tcc?aac?atc?ttc?acc?acc?cac?acc?cca?gtc?cca?gca?ggc?atc?gac?cgc 768

Ser?Asn?Ile?Phe?Thr?Thr?His?Thr?Pro?Val?Pro?Ala?Gly?Ile?Asp?Arg

245 250 255

ttc?gac?atg?gag?atg?gtg?cgt?cgt?tat?ctc?ggt?ggc?ggt?cag?cca?gaa 816

Phe?Asp?Met?Glu?Met?Val?Arg?Arg?Tyr?Leu?Gly?Gly?Gly?Gln?Pro?Glu

260 265 270

gat?cag?cag?ctg?tgc?gtt?ggt?gtt?cca?att?gag?aag?gca?ctt?gag?ctt 864

Asp?Gln?Gln?Leu?Cys?Val?Gly?Val?Pro?Ile?Glu?Lys?Ala?Leu?Glu?Leu

275 280 285

ggt?caa?gag?tcc?gat?cca?cac?cgc?ttc?aac?atg?gct?cat?atg?ggc?ctt 912

Gly?Gln?Glu?Ser?Asp?Pro?His?Arg?Phe?Asn?Met?Ala?His?Met?Gly?Leu

290 295 300

cgc?gcg?agc?caa?cat?gct?aat?ggc?gtc?gca?aag?ctt?cat?ggt?gaa?gta 960

Arg?Ala?Ser?Gln?His?Ala?Asn?Gly?Val?Ala?Lys?Leu?His?Gly?Glu?Val

305 310 315 320

agc?cgt?gac?atg?ttc?gcc?ggc?ctg?tac?ccc?gga?tat?gag?cct?cgt?gaa 1008

Ser?Arg?Asp?Met?Phe?Ala?Gly?Leu?Tyr?Pro?Gly?Tyr?Glu?Pro?Arg?Glu

325 330 335

gtg?ccc?atc?ggg?cac?gtc?acc?aac?ggt?gtt?cac?ctg?ccg?acg?tgg?gtc 1056

Val?Pro?Ile?Gly?His?Val?Thr?Asn?Gly?Val?His?Leu?Pro?Thr?Trp?Val

340 345 350

aag?cca?gag?atg?aag?gaa?ctc?atc?gat?cgc?gtc?act?ggc?ggc?gct?gat 1104

Lys?Pro?Glu?Met?Lys?Glu?Leu?Ile?Asp?Arg?Val?Thr?Gly?Gly?Ala?Asp

355 360 365

ctt?gcg?gtt?gct?gat?tct?tgg?tca?aac?cca?cag?gct?gtc?gag?tct?gag 1152

Leu?Ala?Val?Ala?Asp?Ser?Trp?Ser?Asn?Pro?Gln?Ala?Val?Glu?Ser?Glu

370 375 380

aag?atc?tgg?aag?gtg?cgc?aac?aag?ttc?cgt?gct?gac?cta?gtg?gag?gtt 1200

Lys?Ile?Trp?Lys?Val?Arg?Asn?Lys?Phe?Arg?Ala?Asp?Leu?Val?Glu?Val

385 390 395 400

gct?cgc?gct?gca?act?gca?aag?tcc?tgg?tct?cac?cgt?gga?cac?acc?gaa 1248

Ala?Arg?Ala?Ala?Thr?Ala?Lys?Ser?Trp?Ser?His?Arg?Gly?His?Thr?Glu

405 410 415

gca?gaa?ctt?gcg?tgg?acc?tcc?cgc?gtt?ctg?gat?cca?aac?gtg?ctg?acc 1296

Ala?Glu?Leu?Ala?Trp?Thr?Ser?Arg?Val?Leu?Asp?Pro?Asn?Val?Leu?Thr

420 425 430

att?ggt?ttc?gca?cgt?cgc?gta?tcc?acc?tac?aag?cgc?ttg?acc?ttg?atg 1344

Ile?Gly?Phe?Ala?Arg?Arg?Val?Ser?Thr?Tyr?Lys?Arg?Leu?Thr?Leu?Met

435 440 445

ctg?cgc?aac?cct?gaa?cgc?ctg?cgt?tcc?atc?ttg?ctt?aat?gag?gaa?cgc 1392

Leu?Arg?Asn?Pro?Glu?Arg?Leu?Arg?Ser?Ile?Leu?Leu?Asn?Glu?Glu?Arg

450 455 460

cca?gtt?cag?ttc?gtt?att?gct?ggt?aag?gca?cac?cca?cat?gac?atg?ggt 1440

Pro?Val?Gln?Phe?Val?Ile?Ala?Gly?Lys?Ala?His?Pro?His?Asp?Met?Gly

465 470 475 480

ggc?aag?aag?ctc?atg?cag?gaa?atc?gtc?cac?ttc?gct?gat?caa?gct?ggt 1488

Gly?Lys?Lys?Leu?Met?Gln?Glu?Ile?Val?His?Phe?Ala?Asp?Gln?Ala?Gly

485 490 495

gtc?cgt?gac?cgt?ttc?ctc?ttc?ctg?cct?gat?tac?gac?atc?aac?ctg?gcc 1536

Val?Arg?Asp?Arg?Phe?Leu?Phe?Leu?Pro?Asp?Tyr?Asp?Ile?Asn?Leu?Ala

500 505 510

agc?tac?ctg?atc?tct?ggt?gct?gac?gtg?tgg?ctg?aac?aac?cca?gtg?cgc 1584

Ser?Tyr?Leu?Ile?Ser?Gly?Ala?Asp?Val?Trp?Leu?Asn?Asn?Pro?Val?Arg

515 520 525

cct?cag?gaa?gca?tcg?gga?acc?tcc?ggt?atg?aag?gcc?gtc?atg?aat?ggt 1632

Pro?Gln?Glu?Ala?Ser?Gly?Thr?Ser?Gly?Met?Lys?Ala?Val?Met?Asn?Gly

530 535 540

ggc?ctg?acc?ctg?tcc?atc?tct?gat?ggt?tgg?tgg?gat?gaa?atg?cct?aag 1680

Gly?Leu?Thr?Leu?Ser?Ile?Ser?Asp?Gly?Trp?Trp?Asp?Glu?Met?Pro?Lys

545 550 555 560

gag?acc?acc?ggc?tgg?acc?atc?cca?acc?gtt?gag?tcc?cag?gac?ttg?gaa 1728

Glu?Thr?Thr?Gly?Trp?Thr?Ile?Pro?Thr?Val?Glu?Ser?Gln?Asp?Leu?Glu

565 570 575

tgc?cgc?gac?cac?ctg?gaa?tcc?cag?gcg?ctg?tac?gac?ctg?ctg?gaa?aac 1776

Cys?Arg?Asp?His?Leu?Glu?Ser?Gln?Ala?Leu?Tyr?Asp?Leu?Leu?Glu?Asn

580 585 590

gaa?gtt?gca?ccg?ctg?ttt?tac?aag?cgc?gac?aag?aac?ggc?atc?cca?cag 1824

Glu?Val?Ala?Pro?Leu?Phe?Tyr?Lys?Arg?Asp?Lys?Asn?Gly?Ile?Pro?Gln

595 600 605

gac?tgg?ctg?gac?ctg?gtt?cgc?gaa?tcc?tgg?acc?acc?ctg?tca?cca?atg 1872

Asp?Trp?Leu?Asp?Leu?Val?Arg?Glu?Ser?Trp?Thr?Thr?Leu?Ser?Pro?Met

610 615 620

gtc?acc?tcc?acc?cgc?atg?gtg?cgc?gac?tac?acc?acc?cag?tac?tac?cgc 1920

Val?Thr?Ser?Thr?Arg?Met?Val?Arg?Asp?Tyr?Thr?Thr?Gln?Tyr?Tyr?Arg

625 630 635 640

cca?acc?aaa?cac?cag?gca?gag?ctc?att?gcg?cag?cct?gca?gaa?gca?gcg 1968

Pro?Thr?Lys?His?Gln?Ala?Glu?Leu?Ile?Ala?Gln?Pro?Ala?Glu?Ala?Ala

645 650 655

gat?tac?gcg?gca?tgg?ctt?gag?cac?atc?aaa?gca?gag?tgg?gct?ggc?gtc 2016

Asp?Tyr?Ala?Ala?Trp?Leu?Glu?His?Ile?Lys?Ala?Glu?Trp?Ala?Gly?Val

660 665 670

aag?gtc?tca?gac?ctg?aag?atc?agc?gag?agc?gcc?atc?acg?gcg?cag?gag 2064

Lys?Val?Ser?Asp?Leu?Lys?Ile?Ser?Glu?Ser?Ala?Ile?Thr?Ala?Gln?Glu

675 680 685

ctt?gaa?gtc?agc?gtt?cgc?gtt?gat?tcc?ggt?tcg?ctt?aac?gac?gac?gag 2112

Leu?Glu?Val?Ser?Val?Arg?Val?Asp?Ser?Gly?Ser?Leu?Asn?Asp?Asp?Glu

690 695 700

ttc?caa?gct?cag?gca?ctc?ttt?ggt?gcg?ctc?gga?cac?aac?ggt?gac?atc 2160

Phe?Gln?Ala?Gln?Ala?Leu?Phe?Gly?Ala?Leu?Gly?His?Asn?Gly?Asp?Ile

705 710 715 720

gaa?gat?cca?gaa?atc?acc?gtt?ttg?acc?cca?cgc?ggc?gat?ggc?gcc?tac 2208

Glu?Asp?Pro?Glu?Ile?Thr?Val?Leu?Thr?Pro?Arg?Gly?Asp?Gly?Ala?Tyr

725 730 735

gcg?gca?aag?gtc?agc?act?gac?ctg?cca?ggc?aac?tac?ggc?atc?act?gcc 2256

Ala?Ala?Lys?Val?Ser?Thr?Asp?Leu?Pro?Gly?Asn?Tyr?Gly?Ile?Thr?Ala

740 745 750

cgc?gtt?gtt?cca?aac?aac?agg?atg?ctg?gtc?agc?cca?gcg?gaa?acc?cgc 2304

Arg?Val?Val?Pro?Asn?Asn?Arg?Met?Leu?Val?Ser?Pro?Ala?Glu?Thr?Arg

755 760 765

ctg?atc?acc?tac?ttg?gag?aac?tagggcgaaa?ctagctttac?caa 2348

Leu?Ile?Thr?Tyr?Leu?Glu?Asn

770 775

<210>374

<211>775

<212>PRT

＜213〉Corynebacterium glutamicum

<400>374

Leu?Gly?Arg?Ile?Asn?Ala?Glu?Glu?Gln?Asn?Leu?Ser?Glu?Tyr?Leu?Ser

1 5 10 15

Asp?Lys?Leu?Trp?Tyr?Gln?Asp?Thr?Ala?Asp?Ala?Thr?Asp?Ala?Val?Gly

20 25 30

Asp?Pro?Leu?Val?Ala?Tyr?Phe?Ser?Met?Glu?Phe?Gly?Ile?His?Pro?Ser

35 40 45

Leu?Pro?Ile?Tyr?Ser?Gly?Gly?Leu?Gly?Val?Leu?Ala?Gly?Glu?Asn?Met

50 55 60

Lys?Ser?Ala?Ser?Asp?Leu?Gly?Val?Pro?Leu?Ile?Gly?Val?Gly?Leu?Leu

65 70 75 80

Tyr?Thr?His?Gly?Tyr?Phe?Thr?Gln?Ser?Leu?Ser?Gly?Asp?Gly?Trp?Gln

85 90 95

Gln?Glu?Glu?Tyr?Lys?Tyr?His?Asp?Pro?Ala?Glu?Leu?Pro?Ile?Glu?Ala

100 105 110

Val?Lys?Asp?Lys?Asn?Gly?Glu?Gln?Val?Thr?Val?Ser?Val?Thr?Tyr?Pro

115 120 125

Gly?Ala?Gln?Glu?Val?Lys?Ile?Ala?Leu?Trp?Val?Ala?Asn?Val?Gly?Arg

130 135 140

Ile?Pro?Leu?Leu?Leu?Leu?Asp?Thr?Asn?Ile?Glu?Ala?Asn?Pro?Glu?Glu

145 150 155 160

Leu?Arg?Asn?Val?Thr?Asp?Arg?Leu?Tyr?Gly?Gly?Asp?Asn?Glu?His?Arg

165 170 175

Ile?Lys?Gln?Glu?Leu?Val?Leu?Gly?Val?Gly?Gly?Val?Arg?Ala?Val?Asn

180 185 190

Ala?Phe?Cys?Glu?Ala?Arg?Gly?Leu?Lys?Arg?Ser?Ser?Val?Ala?His?Leu

195 200 205

Asn?Glu?Gly?His?Ala?Gly?Phe?Leu?Thr?Leu?Glu?Arg?Ile?Arg?Glu?Arg

210 215 220

Ile?Ala?Glu?Gly?Met?Glu?Tyr?Pro?Ala?Ala?Phe?Glu?Gln?Val?Arg?Ala

225 230 235 240

Ser?Asn?Ile?Phe?Thr?Thr?His?Thr?Pro?Val?Pro?Ala?Gly?Ile?Asp?Arg

245 250 255

Phe?Asp?Met?Glu?Met?Val?Arg?Arg?Tyr?Leu?Gly?Gly?Gly?Gln?Pro?Glu

260 265 270

Asp?Gln?Gln?Leu?Cys?Val?Gly?Val?Pro?Ile?Glu?Lys?Ala?Leu?Glu?Leu

275 280 285

Gly?Gln?Glu?Ser?Asp?Pro?His?Arg?Phe?Asn?Met?Ala?His?Met?Gly?Leu

290 295 300

Arg?Ala?Ser?Gln?His?Ala?Asn?Gly?Val?Ala?Lys?Leu?His?Gly?Glu?Val

305 310 315 320

Ser?Arg?Asp?Met?Phe?Ala?Gly?Leu?Tyr?Pro?Gly?Tyr?Glu?Pro?Arg?Glu

325 330 335

Val?Pro?Ile?Gly?His?Val?Thr?Asn?Gly?Val?His?Leu?Pro?Thr?Trp?Val

340 345 350

Lys?Pro?Glu?Met?Lys?Glu?Leu?Ile?Asp?Arg?Val?Thr?Gly?Gly?Ala?Asp

355 360 365

Leu?Ala?Val?Ala?Asp?Ser?Trp?Ser?Asn?Pro?Gln?Ala?Val?Glu?Ser?Glu

370 375 380

Lys?Ile?Trp?Lys?Val?Arg?Asn?Lys?Phe?Arg?Ala?Asp?Leu?Val?Glu?Val

385 390 395 400

Ala?Arg?Ala?Ala?Thr?Ala?Lys?Ser?Trp?Ser?His?Arg?Gly?His?Thr?Glu

405 410 415

Ala?Glu?Leu?Ala?Trp?Thr?Ser?Arg?Val?Leu?Asp?Pro?Asn?Val?Leu?Thr

420 425 430

Ile?Gly?Phe?Ala?Arg?Arg?Val?Ser?Thr?Tyr?Lys?Arg?Leu?Thr?Leu?Met

435 440 445

Leu?Arg?Asn?Pro?Glu?Arg?Leu?Arg?Ser?Ile?Leu?Leu?Asn?Glu?Glu?Arg

450 455 460

Pro?Val?Gln?Phe?Val?Ile?Ala?Gly?Lys?Ala?His?Pro?His?Asp?Met?Gly

465 470 475 480

Gly?Lys?Lys?Leu?Met?Gln?Glu?Ile?Val?His?Phe?Ala?Asp?Gln?Ala?Gly

485 490 495

Val?Arg?Asp?Arg?Phe?Leu?Phe?Leu?Pro?Asp?Tyr?Asp?Ile?Asn?Leu?Ala

500 505 510

Ser?Tyr?Leu?Ile?Ser?Gly?Ala?Asp?Val?Trp?Leu?Asn?Asn?Pro?Val?Arg

515 520 525

Pro?Gln?Glu?Ala?Ser?Gly?Thr?Ser?Gly?Met?Lys?Ala?Val?Met?Asn?Gly

530 535 540

Gly?Leu?Thr?Leu?Ser?Ile?Ser?Asp?Gly?Trp?Trp?Asp?Glu?Met?Pro?Lys

545 550 555 560

Glu?Thr?Thr?Gly?Trp?Thr?Ile?Pro?Thr?Val?Glu?Ser?Gln?Asp?Leu?Glu

565 570 575

Cys?Arg?Asp?His?Leu?Glu?Ser?Gln?Ala?Leu?Tyr?Asp?Leu?Leu?G1u?Asn

580 585 590

Glu?Val?Ala?Pro?Leu?Phe?Tyr?Lys?Arg?Asp?Lys?Asn?Gly?Ile?Pro?Gln

595 600 605

Asp?Trp?Leu?Asp?Leu?Val?Arg?Glu?Ser?Trp?Thr?Thr?Leu?Ser?Pro?Met

610 615 620

Val?Thr?Ser?Thr?Arg?Met?Val?Arg?Asp?Tyr?Thr?Thr?Gln?Tyr?Tyr?Arg

625 630 635 640

Pro?Thr?Lys?His?Gln?Ala?Glu?Leu?Ile?Ala?Gln?Pro?Ala?Glu?Ala?Ala

645 650 655

Asp?Tyr?Ala?Ala?Trp?Leu?Glu?His?Ile?Lys?Ala?Glu?Trp?Ala?Gly?Val

660 665 670

Lys?Val?Ser?Asp?Leu?Lys?Ile?Ser?Glu?Ser?Ala?Ile?Thr?Ala?Gln?Glu

675 680 685

Leu?Glu?Val?Ser?Val?Arg?Val?Asp?Ser?Gly?Ser?Leu?Asn?Asp?Asp?Glu

690 695 700

Phe?Gln?Ala?Gln?Ala?Leu?Phe?Gly?Ala?Leu?Gly?His?Asn?Gly?Asp?Ile

705 710 715 720

Glu?Asp?Pro?Glu?Ile?Thr?Val?Leu?Thr?Pro?Arg?Gly?Asp?Gly?Ala?Tyr

725 730 735

Ala?Ala?Lys?Val?Ser?Thr?Asp?Leu?Pro?Gly?Asn?Tyr?Gly?Ile?Thr?Ala

740 745 750

Arg?Val?Val?Pro?Asn?Asn?Arg?Met?Leu?Val?Ser?Pro?Ala?Glu?Thr?Arg

755 760 765

Leu?Ile?Thr?Tyr?Leu?Glu?Asn

770 775

<210>375

<211>941

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(918)

<223>FRXA02100

<400>375

att?gct?ggt?aag?gca?cac?cca?cat?gac?atg?ggt?ggc?aag?aag?ctc?atg 48

Ile?Ala?Gly?Lys?Ala?His?Pro?His?Asp?Met?Gly?Gly?Lys?Lys?Leu?Met

1 5 10 15

cag?gaa?atc?gtc?cac?ttc?gct?gat?caa?gct?ggt?gtc?cgt?gac?cgt?ttc 96

Gln?Glu?Ile?Val?His?Phe?Ala?Asp?Gln?Ala?Gly?Val?Arg?Asp?Arg?Phe

20 25 30

ctc?ttc?ctg?cct?gat?tac?gac?atc?aac?ctg?gcc?agc?tac?ctg?atc?tct 144

Leu?Phe?Leu?Pro?Asp?Tyr?Asp?Ile?Asn?Leu?Ala?Ser?Tyr?Leu?Ile?Ser

35 40 45

ggt?gct?gac?gtg?tgg?ctg?aac?aac?cca?gtg?cgc?cct?cag?gaa?gca?tcg 192

Gly?Ala?Asp?Val?Trp?Leu?Asn?Asn?Pro?Val?Arg?Pro?Gln?Glu?Ala?Ser

50 55 60

gga?acc?tcc?ggt?atg?aag?gcc?gtc?atg?aat?ggt?ggc?ctg?acc?ctg?tcc 240

Gly?Thr?Ser?Gly?Met?Lys?Ala?Val?Met?Asn?Gly?Gly?Leu?Thr?Leu?Ser

65 70 75 80

atc?tct?gat?ggt?tgg?tgg?gat?gaa?atg?cct?aag?gag?acc?acc?ggc?tgg 288

Ile?Ser?Asp?Gly?Trp?Trp?Asp?Glu?Met?Pro?Lys?Glu?Thr?Thr?Gly?Trp

85 90 95

acc?atc?cca?acc?gtt?gag?tcc?cag?gac?ttg?gaa?tgc?cgc?gac?cac?ctg 336

Thr?Ile?Pro?Thr?Val?Glu?Ser?Gln?Asp?Leu?Glu?Cys?Arg?Asp?His?Leu

100 105 110

gaa?tcc?cag?gcg?ctg?tac?gac?ctg?ctg?gaa?aac?gaa?gtt?gca?ccg?ctg 384

Glu?Ser?Gln?Ala?Leu?Tyr?Asp?Leu?Leu?Glu?Asn?Glu?Val?Ala?Pro?Leu

115 120 125

ttt?tac?aag?cgc?gac?aag?aac?ggc?atc?cca?cag?gac?tgg?ctg?gac?ctg 432

Phe?Tyr?Lys?Arg?Asp?Lys?Asn?Gly?Ile?Pro?Gln?Asp?Trp?Leu?Asp?Leu

130 135 140

gtt?cgc?gaa?tcc?tgg?acc?acc?ctg?tca?cca?atg?gtc?acc?tcc?acc?cgc 480

Val?Arg?Glu?Ser?Trp?Thr?Thr?Leu?Ser?Pro?Met?Val?Thr?Ser?Thr?Arg

145 150 155 160

atg?gtg?cgc?gac?tac?acc?acc?cag?tac?tac?cgc?cca?acc?aaa?cac?cag 528

Met?Val?Arg?Asp?Tyr?Thr?Thr?Gln?Tyr?Tyr?Arg?Pro?Thr?Lys?His?Gln

165 170 175

gca?gag?ctc?att?gcg?cag?cct?gca?gaa?gca?gcg?gat?tac?gcg?gca?tgg 576

Ala?Glu?Leu?Ile?Ala?Gln?Pro?Ala?Glu?Ala?Ala?Asp?Tyr?Ala?Ala?Trp

180 185 190

ctt?gag?cac?atc?aaa?gca?gag?tgg?gct?ggc?gtc?aag?gtc?tca?gac?ctg 624

Leu?Glu?His?Ile?Lys?Ala?Glu?Trp?Ala?Gly?Val?Lys?Val?Ser?Asp?Leu

195 200 205

aag?atc?agc?gag?agc?gcc?atc?acg?gcg?cag?gag?ctt?gaa?gtc?agc?gtt 672

Lys?Ile?Ser?Glu?Ser?Ala?Ile?Thr?Ala?Gln?Glu?Leu?Glu?Val?Ser?Val

210 215 220

cgc?gtt?gat?tcc?ggt?tcg?ctt?aac?gac?gac?gag?ttc?caa?gct?cag?gca 720

Arg?Val?Asp?Ser?Gly?Ser?Leu?Asn?Asp?Asp?Glu?Phe?Gln?Ala?Gln?Ala

225 230 235 240

ctc?ttt?ggt?gcg?ctc?gga?cac?aac?ggt?gac?atc?gaa?gat?cca?gaa?atc 768

Leu?Phe?Gly?Ala?Leu?Gly?His?Asn?Gly?Asp?Ile?Glu?Asp?Pro?Glu?Ile

245 250 255

acc?gtt?ttg?acc?cca?cgc?ggc?gat?ggc?gcc?tac?gcg?gca?aag?gtc?agc 816

Thr?Val?Leu?Thr?Pro?Arg?Gly?Asp?Gly?Ala?Tyr?Ala?Ala?Lys?Val?Ser

260 265 270

act?gac?ctg?cca?ggc?aac?tac?ggc?atc?act?gcc?cgc?gtt?gtt?cca?aac 864

Thr?Asp?Leu?Pro?Gly?Asn?Tyr?Gly?Ile?Thr?Ala?Arg?Val?Val?Pro?Asn

275 280 285

aac?agg?atg?ctg?gtc?agc?cca?gcg?gaa?acc?cgc?ctg?atc?acc?tac?ttg 912

Asn?Arg?Met?Leu?Val?Ser?Pro?Ala?Glu?Thr?Arg?Leu?Ile?Thr?Tyr?Leu

290 295 300

gag?aac?tagggcgaaa?ctagctttac?caa 941

Glu?Asn

305

<210>376

<211>306

<212>PRT

＜213〉Corynebacterium glutamicum

<400>376

Ile?Ala?Gly?Lys?Ala?His?Pro?His?Asp?Met?Gly?Gly?Lys?Lys?Leu?Met

1 5 10 15

Gln?Glu?Ile?Val?His?Phe?Ala?Asp?Gln?Ala?Gly?Val?Arg?Asp?Arg?Phe

20 25 30

Leu?Phe?Leu?Pro?Asp?Tyr?Asp?Ile?Asn?Leu?Ala?Ser?Tyr?Leu?Ile?Ser

35 40 45

Gly?Ala?Asp?Val?Trp?Leu?Asn?Asn?Pro?Val?Arg?Pro?Gln?Glu?Ala?Ser

50 55 60

Gly?Thr?Ser?Gly?Met?Lys?Ala?Val?Met?Asn?Gly?Gly?Leu?Thr?Leu?Ser

65 70 75 80

Ile?Ser?Asp?Gly?Trp?Trp?Asp?Glu?Met?Pro?Lys?Glu?Thr?Thr?Gly?Trp

85 90 95

Thr?Ile?Pro?Thr?Val?Glu?Ser?Gln?Asp?Leu?Glu?Cys?Arg?Asp?His?Leu

100 105 110

Glu?Ser?Gln?Ala?Leu?Tyr?Asp?Leu?Leu?Glu?Asn?Glu?Val?Ala?Pro?Leu

115 120 125

Phe?Tyr?Lys?Arg?Asp?Lys?Asn?Gly?Ile?Pro?Gln?Asp?Trp?Leu?Asp?Leu

130 135 140

Val?Arg?Glu?Ser?Trp?Thr?Thr?Leu?Ser?Pro?Met?Val?Thr?Ser?Thr?Arg

145 150 155 160

Met?Val?Arg?Asp?Tyr?Thr?Thr?Gln?Tyr?Tyr?Arg?Pro?Thr?Lys?His?Gln

165 170 175

Ala?Glu?Leu?Ile?Ala?Gln?Pro?Ala?Glu?Ala?Ala?Asp?Tyr?Ala?Ala?Trp

180 185 190

Leu?Glu?His?Ile?Lys?Ala?Glu?Trp?Ala?Gly?Val?Lys?Val?Ser?Asp?Leu

195 200 205

Lys?Ile?Ser?Glu?Ser?Ala?Ile?Thr?Ala?Gln?Glu?Leu?Glu?Val?Ser?Val

210 215 220

Arg?Val?Asp?Ser?Gly?Ser?Leu?Asn?Asp?Asp?Glu?Phe?Gln?Ala?Gln?Ala

225 230 235 240

Leu?Phe?Gly?Ala?Leu?Gly?His?Asn?Gly?Asp?Ile?Glu?Asp?Pro?Glu?Ile

245 250 255

Thr?Val?Leu?Thr?Pro?Arg?Gly?Asp?Gly?Ala?Tyr?Ala?Ala?Lys?Val?Ser

260 265 270

Thr?Asp?Leu?Pro?Gly?Asn?Tyr?Gly?Ile?Thr?Ala?Arg?Val?Val?Pro?Asn

275 280 285

Asn?Arg?Met?Leu?Val?Ser?Pro?Ala?Glu?Thr?Arg?Leu?Ile?Thr?Tyr?Leu

290 295 300

Glu?Asn

305

<210>377

<211>1206

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(1206)

<223>FRXA02113

<400>377

cta?ggt?cga?atc?aac?gcc?gag?gag?caa?aac?ctc?agc?gaa?tac?ctc?agc 48

Leu?Gly?Arg?Ile?Asn?Ala?Glu?Glu?Gln?Asn?Leu?Ser?Glu?Tyr?Leu?Ser

1 5 10 15

gac?aag?ctg?tgg?tac?cag?gac?acc?gca?gat?gca?acc?gat?gct?gtc?gga 96

Asp?Lys?Leu?Trp?Tyr?Gln?Asp?Thr?Ala?Asp?Ala?Thr?Asp?Ala?Val?Gly

20 25 30

gat?cca?ctc?gtt?gcg?tac?ttc?tcc?atg?gag?ttt?ggc?att?cac?cca?agc 144

Asp?Pro?Leu?Val?Ala?Tyr?Phe?Ser?Met?Glu?Phe?Gly?Ile?His?Pro?Ser

35 40 45

ctg?cca?atc?tac?tct?ggc?gga?ctt?ggt?gtg?ctt?gcg?ggc?gag?aac?atg 192

Leu?Pro?Ile?Tyr?Ser?Gly?Gly?Leu?Gly?Val?Leu?Ala?Gly?Glu?Asn?Met

50 55 60

aag?tct?gca?tct?gac?ttg?ggt?gtg?cca?ctg?atc?ggt?gtt?ggt?ttg?ctc 240

Lys?Ser?Ala?Ser?Asp?Leu?Gly?Val?Pro?Leu?Ile?Gly?Val?Gly?Leu?Leu

65 70 75 80

tac?acc?cac?ggc?tac?ttc?acc?cag?tca?ctg?tcc?ggt?gac?ggt?tgg?cag 288

Tyr?Thr?His?Gly?Tyr?Phe?Thr?Gln?Ser?Leu?Ser?Gly?Asp?Gly?Trp?Gln

85 90 95

cag?gaa?gag?tac?aag?tac?cac?gat?cca?gca?gaa?ctg?ccg?att?gag?gca 336

Gln?Glu?Glu?Tyr?Lys?Tyr?His?Asp?Pro?Ala?Glu?Leu?Pro?Ile?Glu?Ala

100 105 110

gtt?aaa?gat?aag?aac?ggc?gag?cag?gtc?act?gtt?tct?gtc?acc?tac?cca 384

Val?Lys?Asp?Lys?Asn?Gly?Glu?Gln?Val?Thr?Val?Ser?Val?Thr?Tyr?Pro

115 120 125

ggt?gcg?cag?gaa?gta?aag?att?gca?ctg?tgg?gta?gca?aac?gtt?ggc?cgc 432

Gly?Ala?Gln?Glu?Val?Lys?Ile?Ala?Leu?Trp?Val?Ala?Asn?Val?Gly?Arg

130 135 140

atc?cca?ttg?ctg?ctg?ctt?gat?acc?aac?atc?gag?gca?aac?cca?gaa?gag 480

Ile?Pro?Leu?Leu?Leu?Leu?Asp?Thr?Asn?Ile?Glu?Ala?Asn?Pro?Glu?Glu

145 150 155 160

ctc?cgc?aac?gtt?act?gac?cgc?ctg?tac?ggt?ggc?gac?aat?gag?cac?cgc 528

Leu?Arg?Asn?Val?Thr?Asp?Arg?Leu?Tyr?Gly?Gly?Asp?Asn?Glu?His?Arg

165 170 175

atc?aag?cag?gaa?ctc?gtt?ctc?ggt?gtt?ggt?ggc?gtc?cgc?gct?gtc?aac 576

Ile?Lys?Gln?Glu?Leu?Val?Leu?Gly?Val?Gly?Gly?Val?Arg?Ala?Val?Asn

180 185 190

gca?ttc?tgc?gaa?gct?cgt?ggt?ctg?aag?cgc?tca?tct?gtt?gca?cac?ctc 624

Ala?Phe?Cys?Glu?Ala?Arg?Gly?Leu?Lys?Arg?Ser?Ser?Val?Ala?His?Leu

195 200 205

aac?gaa?ggc?cac?gca?ggt?ttc?ctg?acc?ctg?gag?cgt?atc?cgc?gag?cgc 672

Asn?Glu?Gly?His?Ala?Gly?Phe?Leu?Thr?Leu?Glu?Arg?Ile?Arg?Glu?Arg

210 215 220

atc?gca?gag?ggc?atg?gag?tac?cca?gca?gca?ttc?gag?cag?gtt?cgt?gcg 720

Ile?Ala?Glu?Gly?Met?Glu?Tyr?Pro?Ala?Ala?Phe?Glu?Gln?Val?Arg?Ala

225 230 235 240

tcc?aac?atc?ttc?acc?acc?cac?acc?cca?gtc?cca?gca?ggc?atc?gac?cgc 768

Ser?Asn?Ile?Phe?Thr?Thr?His?Thr?Pro?Val?Pro?Ala?Gly?Ile?Asp?Arg

245 250 255

ttc?gac?atg?gag?atg?gtg?cgt?cgt?tat?ctc?ggt?ggc?ggt?cag?cca?gaa 816

Phe?Asp?Met?Glu?Met?Val?Arg?Arg?Tyr?Leu?Gly?Gly?Gly?Gln?Pro?Glu

260 265 270

gat?cag?cag?ctg?tgc?gtt?ggt?gtt?cca?att?gag?aag?gca?ctt?gag?ctt 864

Asp?Gln?Gln?Leu?Cys?Val?Gly?Val?Pro?Ile?Glu?Lys?Ala?Leu?Glu?Leu

275 280 285

ggt?caa?gag?tcc?gat?cca?cac?cgc?ttc?aac?atg?gct?cat?atg?ggc?ctt 912

Gly?Gln?Glu?Ser?Asp?Pro?His?Arg?Phe?Asn?Met?Ala?His?Met?Gly?Leu

290 295 300

cgc?gcg?agc?caa?cat?gct?aat?ggc?gtc?gca?aag?ctt?cat?ggt?gaa?gta 960

Arg?Ala?Ser?Gln?His?Ala?Asn?Gly?Val?Ala?Lys?Leu?His?Gly?Glu?Val

305 310 315 320

agc?cgt?gac?atg?ttc?gcc?ggc?ctg?tac?ccc?gga?tat?gag?cct?cgt?gaa 1005

Ser?Arg?Asp?Met?Phe?Ala?Gly?Leu?Tyr?Pro?Gly?Tyr?Glu?Pro?Arg?Glu

325 330 335

gtg?ccc?atc?ggg?cac?gtc?acc?aac?ggt?gtt?cac?ctg?ccg?acg?tgg?gtc 1056

Val?Pro?Ile?Gly?His?Val?Thr?Asn?Gly?Val?His?Leu?Pro?Thr?Trp?Val

340 345 350

aag?cca?gag?atg?aag?gaa?ctc?atc?gat?cgc?gtc?act?ggc?ggc?gct?gat 1104

Lys?Pro?Glu?Met?Lys?Glu?Leu?Ile?Asp?Arg?Val?Thr?Gly?Gly?Ala?Asp

355 360 365

ctt?gcg?gtt?gct?gat?tct?tgg?tca?aac?cca?cag?gct?gtc?gag?tct?gag 1152

Leu?Ala?Val?Ala?Asp?Ser?Trp?Ser?Asn?Pro?Gln?Ala?Val?Glu?Ser?Glu

370 375 380

aag?atc?tgg?aag?gtg?cgc?aac?aag?ttc?cgt?gct?gac?cta?gtg?gag?gtt 1200

Lys?Ile?Trp?Lys?Val?Arg?Asn?Lys?Phe?Arg?Ala?Asp?Leu?Val?Glu?Val

385 390 395 400

gct?cgc 1206

Ala?Arg

<210>378

<211>402

<212>PRT

＜213〉Corynebacterium glutamicum

<400>378

Leu?Gly?Arg?Ile?Asn?Ala?Glu?Glu?Gln?Asn?Leu?Ser?Glu?Tyr?Leu?Ser

1 5 10 15

Asp?Lys?Leu?Trp?Tyr?Gln?Asp?Thr?Ala?Asp?Ala?Thr?Asp?Ala?Val?Gly

20 25 30

Asp?Pro?Leu?Val?Ala?Tyr?Phe?Ser?Met?Glu?Phe?Gly?Ile?His?Pro?Ser

35 40 45

Leu?Pro?Ile?Tyr?Ser?Gly?Gly?Leu?Gly?Val?Leu?Ala?Gly?Glu?Asn?Met

50 55 60

Lys?Ser?Ala?Ser?Asp?Leu?Gly?Val?Pro?Leu?Ile?Gly?Val?Gly?Leu?Leu

65 70 75 80

Tyr?Thr?His?Gly?Tyr?Phe?Thr?Gln?Ser?Leu?Ser?Gly?Asp?Gly?Trp?Gln

85 90 95

Gln?Glu?Glu?Tyr?Lys?Tyr?His?Asp?Pro?Ala?Glu?Leu?Pro?Ile?Glu?Ala

100 105 110

Val?Lys?Asp?Lys?Asn?Gly?Glu?Gln?Val?Thr?Val?Ser?Val?Thr?Tyr?Pro

115 120 125

Gly?Ala?Gln?Glu?Val?Lys?Ile?Ala?Leu?Trp?Val?Ala?Asn?Val?Gly?Arg

130 135 140

Ile?Pro?Leu?Leu?Leu?Leu?Asp?Thr?Asn?Ile?Glu?Ala?Asn?Pro?Glu?Glu

145 150 155 160

Leu?Arg?Asn?Val?Thr?Asp?Arg?Leu?Tyr?Gly?Gly?Asp?Asn?Glu?His?Arg

165 170 175

Ile?Lys?Gln?Glu?Leu?Val?Leu?Gly?Val?Gly?Gly?Val?Arg?Ala?Val?Asn

180 185 190

Ala?Phe?Cys?Glu?Ala?Arg?Gly?Leu?Lys?Arg?Ser?Ser?Val?Ala?His?Leu

195 200 205

Asn?Glu?Gly?His?Ala?Gly?Phe?Leu?Thr?Leu?Glu?Arg?Ile?Arg?Glu?Arg

210 215 220

Ile?Ala?Glu?Gly?Met?Glu?Tyr?Pro?Ala?Ala?Phe?Glu?Gln?Val?Arg?Ala

225 230 235 240

Ser?Asn?Ile?Phe?Thr?Thr?His?Thr?Pro?Val?Pro?Ala?Gly?Ile?Asp?Arg

245 250 255

Phe?Asp?Met?Glu?Met?Val?Arg?Arg?Tyr?Leu?Gly?Gly?Gly?Gln?Pro?Glu

260 265 270

Asp?Gln?Gln?Leu?Cys?Val?Gly?Val?Pro?Ile?Glu?Lys?Ala?Leu?Glu?Leu

275 280 285

Gly?Gln?Glu?Ser?Asp?Pro?His?Arg?Phe?Asn?Met?Ala?His?Met?Gly?Leu

290 295 300

Arg?Ala?Ser?Gln?His?Ala?Asn?Gly?Val?Ala?Lys?Leu?His?Gly?Glu?Val

305 310 315 320

Ser?Arg?Asp?Met?Phe?Ala?Gly?Leu?Tyr?Pro?Gly?Tyr?Glu?Pro?Arg?Glu

325 330 335

Val?Pro?Ile?Gly?His?Val?Thr?Asn?Gly?Val?His?Leu?Pro?Thr?Trp?Val

340 345 350

Lys?Pro?Glu?Met?Lys?Glu?Leu?Ile?Asp?Arg?Val?Thr?Gly?Gly?Ala?Asp

355 360 365

Leu?Ala?Val?Ala?Asp?Ser?Trp?Ser?Asn?Pro?Gln?Ala?Val?Glu?Ser?Glu

370 375 380

Lys?Ile?Trp?Lys?Val?Arg?Asn?Lys?Phe?Arg?Ala?Asp?Leu?Val?Glu?Val

385 390 395 400

Ala?Arg

<210>379

<211>1140

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1117)

<223>RXA02147

<400>379

aaaagttgag?agcggcttgc?ttcttttcct?tggctaggct?tttgtaatcg?ggttagagta?60

gtggagttgc?ttgaatgagg?ttgatagggg?atttttgaag?atg?ttt?ggt?cgc?cgt 115

Met?Phe?Gly?Arg?Arg

1 5

tgg?gtg?agc?gtt?gtg?gcg?tca?tgt?gtt?atc?gca?agc?acg?ctg?att?ctg 163

Trp?Val?Ser?Val?Val?Ala?Ser?Cys?Val?Ile?Ala?Ser?Thr?Leu?Ile?Leu

10 15 20

gtg?cct?tcg?cat?tcc?ggt?gcg?gag?gaa?gtc?gat?caa?ctg?att?gct?gat 211

Val?Pro?Ser?His?Ser?Gly?Ala?Glu?Glu?Val?Asp?Gln?Leu?Ile?Ala?Asp

25 30 35

atc?gag?cat?gtc?tct?cag?gaa?acg?tct?gcc?cag?aat?gag?gaa?gtc?aaa 259

Ile?Glu?His?Val?Ser?Gln?Glu?Thr?Ser?Ala?Gln?Asn?Glu?Glu?Val?Lys

40 45 50

cag?ctt?gag?att?gat?att?gag?gct?cgt?gag?gtc?acg?atc?aag?gaa?gtt 307

Gln?Leu?Glu?Ile?Asp?Ile?Glu?Ala?Arg?Glu?Val?Thr?Ile?Lys?Glu?Val

55 60 65

cag?gag?cag?tcg?gta?agc?tac?cgt?gag?gcg?gct?gat?caa?gca?tcg?gag 355

Gln?Glu?Gln?Ser?Val?Ser?Tyr?Arg?Glu?Ala?Ala?Asp?Gln?Ala?Ser?Glu

70 75 80 85

aat?gtc?gaa?gct?tat?cgt?tcg?gag?atc?aat?cgg?atc?gct?cag?gcg?aag 403

Asn?Val?Glu?Ala?Tyr?Arg?Ser?Glu?Ile?Asn?Arg?Ile?Ala?Gln?Ala?Lys

90 95 100

tat?cgt?ggc?aca?gtc?acg?gat?cct?ttg?agc?att?gcg?gtg?tct?gca?gaa 451

Tyr?Arg?Gly?Thr?Val?Thr?Asp?Pro?Leu?Ser?Ile?Ala?Val?Ser?Ala?Glu

105 110 115

gat?cca?caa?aac?gtg?att?gat?cgg?atg?agc?tac?ctt?tca?acg?ttg?act 499

Asp?Pro?Gln?Asn?Val?Ile?Asp?Arg?Met?Ser?Tyr?Leu?Ser?Thr?Leu?Thr

120 125 130

aag?tcc?act?agt?gat?gtg?gtt?gaa?tcc?ctc?aac?gcg?gag?act?gag?aag 547

Lys?Ser?Thr?Ser?Asp?Val?Val?Glu?Ser?Leu?Asn?Ala?Glu?Thr?Glu?Lys

135 140 145

tcc?gca?gaa?gct?gtg?tat?caa?gca?aac?cgt?act?aag?gcg?gaa?gcg?gag 595

Ser?Ala?Glu?Ala?Val?Tyr?Gln?Ala?Asn?Arg?Thr?Lys?Ala?Glu?Ala?Glu

150 155 160 165

ttc?cag?ttg?ggg?cag?ctg?aag?gta?cgc?cag?gcg?gag?ctt?gaa?tct?gaa 643

Phe?Gln?Leu?Gly?Gln?Leu?Lys?Val?Arg?Gln?Ala?Glu?Leu?Glu?Ser?Glu

170 175 180

aag?gaa?gca?ttg?gat?ggt?cga?aaa?tcg?gag?atc?cga?gac?cgg?gtg?gat 691

Lys?Glu?Ala?Leu?Asp?Gly?Arg?Lys?Ser?Glu?Ile?Arg?Asp?Arg?Val?Asp

185 190 195

gcc?ctg?acg?cca?cag?gag?cgg?gaa?atg?tgg?gtt?gct?aag?aat?ggt?cca 739

Ala?Leu?Thr?Pro?Gln?Glu?Arg?Glu?Met?Trp?Val?Ala?Lys?Asn?Gly?Pro

200 205 210

ttg?gac?att?gat?ctg?act?gat?ttg?ctt?ggt?ctt?tcc?gct?gcg?act?tcg 787

Leu?Asp?Ile?Asp?Leu?Thr?Asp?Leu?Leu?Gly?Leu?Ser?Ala?Ala?Thr?Ser

215 220 225

ggt?gcg?gtg?gat?gct?gcc?ttg?tct?aag?ttg?gga?agc?cct?tat?ggt?tgg 835

Gly?Ala?Val?Asp?Ala?Ala?Leu?Ser?Lys?Leu?Gly?Ser?Pro?Tyr?Gly?Trp

230 235 240 245

ggt?ggc?att?ggc?cca?aat?gag?ttt?gat?tgc?tca?ggt?ttg?atc?tat?tgg 883

Gly?Gly?Ile?Gly?Pro?Asn?Glu?Phe?Asp?Cys?Ser?Gly?Leu?Ile?Tyr?Trp

250 255 260

gcg?tat?cag?cag?atg?ggt?aag?act?ttg?cca?cgt?acg?tct?caa?gct?cag 931

Ala?Tyr?Gln?Gln?Met?Gly?Lys?Thr?Leu?Pro?Arg?Thr?Ser?Gln?Ala?Gln

265 270 275

atg?gct?ggc?gga?acg?ccg?gtg?agc?aga?gat?gag?ctg?cag?cct?ggc?gat 979

Met?Ala?Gly?Gly?Thr?Pro?Val?Ser?Arg?Asp?Glu?Leu?Gln?Pro?Gly?Asp

280 285 290

gtc?att?gga?tat?tac?cca?ggt?gct?act?cac?gtg?gga?ctg?tat?att?ggg 1027

Val?Ile?Gly?Tyr?Tyr?Pro?Gly?Ala?Thr?His?Val?Gly?Leu?Tyr?Ile?Gly

295 300 305

gac?gga?aag?att?gtg?cac?gcc?tca?gac?tac?gga?atc?cct?gtg?cag?gtg 1075

Asp?Gly?Lys?Ile?Val?His?Ala?Ser?Asp?Tyr?Gly?Ile?Pro?Val?Gln?Val

310 315 320 325

gta?tct?gtt?gat?tca?gca?ccg?ttt?tat?ggt?gcg?cgt?cgc?tac 1117

Val?Ser?Val?Asp?Ser?Ala?Pro?Phe?Tyr?Gly?Ala?Arg?Arg?Tyr

330 335

taagaaatag?ttcgtcagga?gaa 1140

<210>380

<211>339

<212>PRT

＜213〉Corynebacterium glutamicum

<400>380

Met?Phe?Gly?Arg?Arg?Trp?Val?Ser?Val?Val?Ala?Ser?Cys?Val?Ile?Ala

1 5 10 15

Ser?Thr?Leu?Ile?Leu?Val?Pro?Ser?His?Ser?Gly?Ala?Glu?Glu?Val?Asp

20 25 30

Gln?Leu?Ile?Ala?Asp?Ile?Glu?His?Val?Ser?Gln?Glu?Thr?Ser?Ala?Gln

35 40 45

Asn?Glu?Glu?Val?Lys?Gln?Leu?Glu?Ile?Asp?Ile?Glu?Ala?Arg?Glu?Val

50 55 60

Thr?Ile?Lys?Glu?Val?Gln?Glu?Gln?Ser?Val?Ser?Tyr?Arg?Glu?Ala?Ala

65 70 75 80

Asp?Gln?Ala?Ser?Glu?Asn?Val?Glu?Ala?Tyr?Arg?Ser?Glu?Ile?Asn?Arg

85 90 95

Ile?Ala?Gln?Ala?Lys?Tyr?Arg?Gly?Thr?Val?Thr?Asp?Pro?Leu?Ser?Ile

100 105 110

Ala?Val?Ser?Ala?Glu?Asp?Pro?Gln?Asn?Val?Ile?Asp?Arg?Met?Ser?Tyr

115 120 125

Leu?Ser?Thr?Leu?Thr?Lys?Ser?Thr?Ser?Asp?Val?Val?Glu?Ser?Leu?Asn

130 135 140

Ala?Glu?Thr?Glu?Lys?Ser?Ala?Glu?Ala?Val?Tyr?Gln?Ala?Asn?Arg?Thr

145 150 155 160

Lys?Ala?Glu?Ala?Glu?Phe?Gln?Leu?Gly?Gln?Leu?Lys?Val?Arg?Gln?Ala

165 170 175

Glu?Leu?Glu?Ser?Glu?Lys?Glu?Ala?Leu?Asp?Gly?Arg?Lys?Ser?Glu?Ile

180 185 190

Arg?Asp?Arg?Val?Asp?Ala?Leu?Thr?Pro?Gln?Glu?Arg?Glu?Met?Trp?Val

195 200 205

Ala?Lys?Asn?Gly?Pro?Leu?Asp?Ile?Asp?Leu?Thr?Asp?Leu?Leu?Gly?Leu

210 215 220

Ser?Ala?Ala?Thr?Ser?Gly?Ala?Val?Asp?Ala?Ala?Leu?Ser?Lys?Leu?Gly

225 230 235 240

Ser?Pro?Tyr?Gly?Trp?Gly?Gly?Ile?Gly?Pro?Asn?Glu?Phe?Asp?Cys?Ser

245 250 255

Gly?Leu?Ile?Tyr?Trp?Ala?Tyr?Gln?Gln?Met?Gly?Lys?Thr?Leu?Pro?Arg

260 265 270

Thr?Ser?Gln?Ala?Gln?Met?Ala?Gly?Gly?Thr?Pro?Val?Ser?Arg?Asp?Glu

275 280 285

Leu?Gln?Pro?Gly?Asp?Val?Ile?Gly?Tyr?Tyr?Pro?Gly?Ala?Thr?His?Val

290 295 300

Gly?Leu?Tyr?Ile?Gly?Asp?Gly?Lys?Ile?Val?His?Ala?Ser?Asp?Tyr?Gly

305 310 315 320

Ile?Pro?Val?Gln?Val?Val?Ser?Val?Asp?Ser?Ala?Pro?Phe?Tyr?Gly?Ala

325 330 335

Arg?Arg?Tyr

<210>381

<211>1959

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<22l>CDS

<222>(101)..(1936)

<223>RXA01478

<400>381

gcgggttttg?ttgtggaggg?gcgcgtcgaa?aagcaatttt?ttttccaaga?tagctcactt?60

tattggagtc?acctggcctg?aaatcctcta?ctctgggcgc?atg?acc?att?cca?gga 115

Met?Thr?Ile?Pro?Gly

1 5

gct?tcc?aca?cag?act?gat?atc?cct?ctg?gac?aca?ctt?ctt?gag?gat?tac 163

Ala?Ser?Thr?Gln?Thr?Asp?Ile?Pro?Leu?Asp?Thr?Leu?Leu?Glu?Asp?Tyr

10 15 20

gcg?cra?ctg?tca?gac?act?cac?acc?ggc?gct?ctg?ctg?tcc?aac?atg?ggc 211

Ala?Leu?Leu?Ser?Asp?Thr?His?Thr?Gly?Ala?Leu?Leu?Ser?Asn?Met?Gly

25 30 35

agt?ttg?gac?tgg?ttg?tgc?ctg?cct?cgt?ttt?gat?tcc?caa?gcc?atg?ttc 259

Ser?Leu?Asp?Trp?Leu?Cys?Leu?Pro?Arg?Phe?Asp?Ser?Gln?Ala?Met?Phe

40 45 50

acc?agg?ctg?ctt?ggt?gat?cgc?gag?cac?gga?cac?tgg?agt?ttg?cgt?gtc 307

Thr?Arg?Leu?Leu?Gly?Asp?Arg?Glu?His?Gly?His?Trp?Ser?Leu?Arg?Val

55 60 65

cca?ggt?ggt?gag?gtg?atc?agc?caa?aac?tac?ctc?ggc?gat?tcc?ttc?gtg 355

Pro?Gly?Gly?Glu?Val?Ile?Ser?Gln?Asn?Tyr?Leu?Gly?Asp?Ser?Phe?Val

70 75 80 85

gtg?cag?acc?gtg?tgg?cgt?tca?gag?acc?ggt?act?gcc?cgg?gtt?gtt?gat 403

Val?Gln?Thr?Val?Trp?Arg?Ser?Glu?Thr?Gly?Thr?Ala?Arg?Val?Val?Asp

90 95 100

ttc?atg?cca?att?cac?ggt?caa?gaa?caa?ccc?gat?atc?acc?gac?ctg?gtg 451

Phe?Met?Pro?Ile?His?Gly?Gln?Glu?Gln?Pro?Asp?Ile?Thr?Asp?Leu?Val

105 110 115

cgc?tct?gtg?cac?tgc?gtg?gaa?ggc?gaa?gtg?gat?gtg?gaa?tcg?atc?ctg 499

Arg?Ser?Val?His?Cys?Val?Glu?Gly?Glu?Val?Asp?Val?Glu?Set?lle?Leu

120 125 130

cgc?ctg?cgt?ttt?gat?tat?ggc?gag?tcc?act?ccg?tat?ttc?cgc?acc?agc 547

Arg?Leu?Arg?Phe?Asp?Tyr?Gly?Glu?Set?Thr?Pro?Tyr?Phe?Arg?Thr?Ser

135 140 145

act?gtc?gac?ggc?atc?agc?atc?gtg?cag?gct?gtc?gcc?ggc?ccc?aat?gcg 595

Thr?Val?Asp?Gly?Ile?Set?Ile?Val?Gln?Ala?Val?Ala?Gly?Pro?Asn?Ala

150 155 160 165

gta?tat?gtt?cgt?gga?cct?gag?atg?cca?cac?cgc?cct?gca?aag?gat?tgt 643

Val?Tyr?Val?Arg?Gly?Pro?Glu?Met?Pro?His?Arg?Pro?Ala?Lys?Asp?Cys

170 175 180

cac?agt?ggc?acc?ttc?cac?ctg?acg?gcc?ggc?gaa?tcc?gtg?gaa?tgg?gtt 691

His?Ser?Gly?Thr?Phe?His?Leu?Thr?Ala?Gly?Glu?Ser?Val?Glu?Trp?Val

185 190 195

ctc?acc?tgg?gca?ccg?tcg?ttc?gaa?ccg?cat?ccc?ccc?atg?ccg?gat?tac 739

Leu?Thr?Trp?Ala?Pro?Ser?Phe?Glu?Pro?His?Pro?Pro?Met?Pro?Asp?Tyr

200 205 210

acc?cgc?tct?ttg?gag?agc?acc?ttg?agc?ttc?tgg?gca?tca?tgg?gtt?gaa 787

Thr?Arg?Ser?Leu?Glu?Ser?Thr?Leu?Ser?Phe?Trp?Ala?Ser?Trp?Val?Glu

215 220 225

gag?ctc?ccc?cac?cag?cgc?ctc?tac?gac?gct?gaa?gtc?cgc?cgc?tcc?atg 835

Glu?Leu?Pro?His?Gln?Arg?Leu?Tyr?Asp?Ala?Glu?Val?Arg?Arg?Ser?Met

230 235 240 245

crc?gta?ctg?cgc?gcc?ttg?acc?gat?cta?caa?acc?ggt?ggc?atc?gtg?gcc 883

Leu?Val?Leu?Arg?Ala?Leu?Thr?Asp?Leu?Gln?Thr?Gly?Gly?Ile?Val?Ala

250 255 260

gca?ccg?acc?acc?tca?cta?ccg?gag?gat?ttc?gga?ggc?gtc?cgt?aac?tgg 931

Ala?Pro?Thr?Thr?Ser?Leu?Pro?Glu?Asp?Phe?Gly?Gly?Ile?Arg?Ash?Trp

265 270 275

gac?tac?cgc?tac?gtg?tgg?ctg?cgc?gac?tcc?gca?ctc?acc?att?gaa?gcc 979

Asp?Tyr?Arg?Tyr?Val?Trp?Leu?Arg?Asp?Ser?Ala?Leu?Thr?Ile?Glu?Ala

280 285 290

ctc?gtg?gaa?tac?gga?ttc?tcc?caa?gca?gcc?ctc?caa?tgg?cgc?acc?tgg 1027

Leu?Val?Glu?Tyr?Gly?Phe?Ser?Gln?Ala?Ala?Leu?Gln?Trp?Arg?Thr?Trp

295 300 305

ctg?ctg?cgc?gcc?atc?gca?ggc?gac?ccg?gaa?aac?ctc?cgc?atc?atg?tat 1075

Leu?Leu?Arg?Ala?Ile?Ala?Gly?Asp?Pro?Glu?Asn?Leu?Arg?Ile?Met?Tyr

310 315 320 325

ggc?ctc?ggc?ggc?gaa?cga?cac?ctc?cct?gaa?cgc?gaa?ctc?caa?cac?ctg 1123

Gly?Leu?Gly?Gly?Glu?Arg?His?Leu?Pro?Glu?Arg?Glu?Leu?Gln?His?Leu

330 335 340

cgc?gga?tac?gaa?aac?tcc?gtg?cct?gtt?cgc?gtt?ggc?aat?gga?gcc?gcc 1171

Arg?Gly?Tyr?Glu?Asn?Ser?Val?Pro?Val?Arg?Val?Gly?Asn?Gly?Ala?Ala

345 350 355

gaa?caa?tac?caa?gca?gat?gtc?gtc?ggc?gaa?gta?atg?gtc?gcg?ctt?gaa 1219

Glu?Gln?Tyr?Gln?Ala?Asp?Val?Val?Gly?Glu?Val?Met?Val?Ala?Leu?Glu

360 365 370

acc?atc?cgc?cgc?gcc?ggg?tgc?ctc?gag?gac?gaa?ttc?tcc?tgg?ggc?atg 1267

Thr?Ile?Arg?Arg?Ala?Gly?Cys?Leu?Glu?Asp?Glu?Phe?Ser?Trp?Gly?Met

375 380 385

caa?aaa?gcc?atc?ctc?gat?ttc?caa?gaa?gcc?aac?ttc?gac?cgc?aag?gat 1315

Gln?Lys?Ala?Ile?Leu?Asp?Phe?Gln?Glu?Ala?Asn?Phe?Asp?Arg?Lys?Asp

390 395 400 405

caa?ggc?atc?tgg?gaa?atg?cgc?tcc?gaa?ccg?caa?tat?ttc?acc?cac?ggc 1363

Gln?Gly?Ile?Trp?Glu?Met?Arg?Ser?Glu?Pro?Gln?Tyr?Phe?Thr?His?Gly

410 415 420

cgc?gcc?atg?atg?tgg?gcc?ggc?ttc?gac?cgc?ggc?atc?aaa?gcc?atc?gaa 1411

Arg?Ala?Met?Met?Trp?Ala?Gly?Phe?Asp?Arg?Gly?Ile?Lys?Ala?Ile?Glu

425 430 435

gaa?ttc?aac?ctc?gac?ggc?ccc?atc?gag?cgc?tgg?cgt?gaa?ctc?cgc?gcc 1459

Glu?Phe?Asn?Leu?Asp?Gly?Pro?Ile?Glu?Arg?Trp?Arg?Glu?Leu?Arg?Ala

440 445 450

aaa?ctc?cgc?gaa?gaa?atc?atg?acc?aac?ggc?ttc?aac?gaa?gag?atc?caa 1507

Lys?Leu?Arg?Glu?Glu?Ile?Met?Thr?Asn?Gly?Phe?Asn?Glu?Glu?Ile?Gln

455 460 465

tcc?ttc?acc?cag?tgc?tac?gac?aac?acc?caa?gtc?gac?gcc?tcg?ctg?ctt 1555

Ser?Phe?Thr?Gln?Cys?Tyr?Asp?Asn?Thr?Gln?Val?Asp?Ala?Ser?Leu?Leu

470 475 480 485

cag?ctc?gcc?caa?ata?ggc?ttc?atc?ggc?ttc?gac?gat?cca?aaa?atg?ctc 1603

Gln?Leu?Ala?Gln?Ile?Gly?Phe?Ile?Gly?Phe?Asp?Asp?Pro?Lys?Met?Leu

490 495 500

agc?acc?gta?gcg?cgc?att?gag?caa?gag?ctt?ctc?gac?gcc?cac?ggc?ttt 1651

Ser?Thr?Val?Ala?Arg?Ile?Glu?Gln?Glu?Leu?Leu?Asp?Ala?His?Gly?Phe

505 510 515

ctt?cac?agg?tac?cac?acc?gac?ggg?tct?gac?ggc?ctt?gcc?ggc?gac?gaa 1699

Leu?His?Arg?Tyr?His?Thr?Asp?Gly?Ser?Asp?Gly?Leu?Ala?Gly?Asp?Glu

520 525 530

tac?ccc?ttc?ctc?atc?tgt?tca?ttc?tgg?ctg?gta?gaa?caa?tac?gca?agc 1747

Tyr?Pro?Phe?Leu?Ile?Cys?Ser?Phe?Trp?Leu?Val?G1u?G1n?Tyr?Ala?Ser

535 540 545

tcc?aac?cgc?ctc?gac?gag?gcc?aaa?gaa?aag?atg?aac?cgc?atc?ctt?gcc 1795

Ser?Asn?Arg?Leu?Asp?Glu?Ala?Lys?Glu?Lys?Met?Asn?Arg?Ile?Leu?Ala

550 555 560 565

gtc?caa?agc?cca?ctt?ggc?cta?ctg?gct?gag?gaa?tac?tcc?acc?cac?cat 1843

Val?Gln?Ser?Pro?Leu?Gly?Leu?Leu?Ala?Glu?Glu?Tyr?Ser?Thr?His?His

570 575 580

ggc?agg?ctc?gct?gga?aac?tac?cct?cag?gcc?ttt?tcc?cac?att?ggt?ctg 1891

Gly?Arg?Leu?Ala?Gly?Asn?Tyr?Pro?Gln?Ala?Phe?Ser?His?Ile?Gly?Leu

585 590 595

atc?agc?gct?gcc?cgt?gcc?ata?aat?ttc?gaa?gaa?gcg?cga?aac?agg 1936

Ile?Ser?Ala?Ala?Arg?Ala?Ile?Asn?Phe?Glu?Glu?Ala?Arg?Asn?Arg

600 605 610

tagagtctaa?ggtgtcattc?ttg 1959

<210>382

<211>612

<212>PRT

＜213〉Corynebacterium glutamicum

<400>382

Met?Thr?Ile?Pro?Gly?Ala?Ser?Thr?Gln?Thr?Asp?Ile?Pro?Leu?Asp?Thr

1 5 10 15

Leu?Leu?Glu?Asp?Tyr?Ala?Leu?Leu?Ser?Asp?Thr?His?Thr?Gly?Ala?Leu

20 25 30

Leu?Ser?Asn?Met?Gly?Ser?Leu?Asp?Trp?Leu?Cys?Leu?Pro?Arg?Phe?Asp

35 40 45

Ser?Gln?Ala?Met?Phe?Thr?Arg?Leu?Leu?Gly?Asp?Arg?Glu?His?Gly?His

50 55 60

Trp?Ser?Leu?Arg?Val?Pro?Gly?Gly?Glu?Val?Ile?Ser?Gln?Asn?Tyr?Leu

65 70 75 80

Gly?Asp?Ser?Phe?Val?Val?Gln?Thr?Val?Trp?Arg?Ser?Glu?Thr?Gly?Thr

85 90 95

Ala?Arg?Val?Val?Asp?Phe?Met?Pro?Ile?His?Gly?Gln?Glu?Gln?Pro?Asp

100 105 110

Ile?Thr?Asp?Leu?Val?Arg?Ser?Val?His?Cys?Val?Glu?Gly?Glu?Val?Asp

115 120 125

Val?Glu?Ser?Ile?Leu?Arg?Leu?Arg?Phe?Asp?Tyr?Gly?Glu?Ser?Thr?Pro

130 135 140

Tyr?Phe?Arg?Thr?Ser?Thr?Val?Asp?Gly?Ile?Ser?Ile?Val?Gln?Ala?Val

145 150 155 160

Ala?Gly?Pro?Asn?Ala?Val?Tyr?Val?Arg?Gly?Pro?Glu?Met?Pro?His?Arg

165 170 175

Pro?Ala?Lys?Asp?Cys?His?Ser?Gly?Thr?Phe?His?Leu?Thr?Ala?Gly?Glu

180 185 190

Ser?Val?Glu?Trp?Val?Leu?Thr?Trp?Ala?Pro?Ser?Phe?Glu?Pro?His?Pro

195 200 205

Pro?Met?Pro?Asp?Tyr?Thr?Arg?Ser?Leu?Glu?Ser?Thr?Leu?Ser?Phe?Trp

210 215 220

Ala?Ser?Trp?Val?Glu?Glu?Leu?Pro?His?Gln?Arg?Leu?Tyr?Asp?Ala?Glu

225 230 235 240

Val?Arg?Arg?Ser?Met?Leu?Val?Leu?Arg?Ala?Leu?Thr?Asp?Leu?Gln?Thr

245 250 255

Gly?Gly?Ile?Val?Ala?Ala?Pro?Thr?Thr?Ser?Leu?Pro?Glu?Asp?Phe?Gly

260 265 270

Gly?Ile?Arg?Asn?Trp?Asp?Tyr?Arg?Tyr?Val?Trp?Leu?Arg?Asp?Ser?Ala

275 280 285

Leu?Thr?Ile?Glu?Ala?Leu?Val?Glu?Tyr?Gly?Phe?Ser?Gln?Ala?Ala?Leu

290 295 300

Gln?Trp?Arg?Thr?Trp?Leu?Leu?Arg?Ala?Ile?Ala?Gly?Asp?Pro?Glu?Asn

305 310 315 320

Leu?Arg?Ile?Met?Tyr?Gly?Leu?Gly?Gly?Glu?Arg?His?Leu?Pro?Glu?Arg

325 330 335

Glu?Leu?Gln?His?Leu?Arg?Gly?Tyr?Glu?Asn?Ser?Val?Pro?Val?Arg?Val

340 345 350

Gly?Asn?Gly?Ala?Ala?Glu?Gln?Tyr?Gln?Ala?Asp?Val?Val?Gly?Glu?Val

355 360 365

Met?Val?Ala?Leu?Glu?Thr?Ile?Arg?Arg?Ala?Gly?Cys?Leu?Glu?Asp?Glu

370 375 380

Phe?Ser?Trp?Gly?Met?Gln?Lys?Ala?Ile?Leu?Asp?Phe?Gln?Glu?Ala?Asn

385 390 395 400

Phe?Asp?Arg?Lys?Asp?Gln?Gly?Ile?Trp?Glu?Met?Arg?Ser?Glu?Pro?Gln

405 410 415

Tyr?Phe?Thr?His?Gly?Arg?Ala?Met?Met?Trp?Ala?Gly?Phe?Asp?Arg?Gly

420 425 430

Ile?Lys?Ala?Ile?Glu?Glu?Phe?Asn?Leu?Asp?Gly?Pro?Ile?Glu?Arg?Trp

435 440 445

Arg?Glu?Leu?Arg?Ala?Lys?Leu?Arg?Glu?Glu?Ile?Met?Thr?Asn?Gly?Phe

450 455 460

Asn?Glu?Glu?Ile?Gln?Ser?Phe?Thr?Gln?Cys?Tyr?Asp?Asn?Thr?Gln?Val

465 470 475 480

Asp?Ala?Ser?Leu?Leu?Gln?Leu?Ala?Gln?Ile?Gly?Phe?Ile?Gly?Phe?Asp

485 490 495

Asp?Pro?Lys?Met?Leu?Ser?Thr?Val?Ala?Arg?Ile?Glu?Gln?Glu?Leu?Leu

500 505 510

Asp?Ala?His?Gly?Phe?Leu?His?Arg?Tyr?His?Thr?Asp?Gly?Ser?Asp?Gly

515 520 525

Leu?Ala?Gly?Asp?Glu?Tyr?Pro?Phe?Leu?Ile?Cys?Ser?Phe?Trp?Leu?Val

530 535 540

Glu?Gln?Tyr?Ala?Ser?Ser?Asn?Arg?Leu?Asp?Glu?Ala?Lys?Glu?Lys?Met

545 550 555 560

Asn?Arg?Ile?Leu?Ala?Val?Gln?Ser?Pro?Leu?Gly?Leu?Leu?Ala?Glu?Glu

565 570 575

Tyr?Ser?Thr?His?His?Gly?Arg?Leu?Ala?Gly?Asn?Tyr?Pro?Gln?Ala?Phe

580 585 590

Ser?His?Ile?Gly?Leu?Ile?Ser?Ala?Ala?Arg?Ala?Ile?Asn?Phe?Glu?Glu

595 600 605

Ala?Arg?Asn?Arg

610

<210>383

<211>658

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(658)

<223>RXA01888

<400>383

agtagatact?agataccacc?cattgatgcc?gtcaaggggt?ttcctgtaaa?gatgtaagag?60

attaagaaaa?gaggtagata?tggcgtcaaa?gcgaccgaca?atg?gct?gat?gtg?gca 115

Met?Ala?Asp?Val?Ala

1 5

aaa?gct?gct?gga?gta?tcc?act?gcg?ctg?gtc?tcc?atc?gtg?ttt?cgc?gat 163

Lys?Ala?Ala?Gly?Val?Ser?Thr?Ala?Leu?Val?Ser?Ile?Val?Phe?Arg?Asp

10 15 20

gcc?ccc?gga?gca?agt?gaa?tcc?acc?cgc?aac?cat?gtg?aaa?gaa?aaa?gcc 211

Ala?Pro?Gly?Ala?Ser?Glu?Ser?Thr?Arg?Asn?His?Val?Lys?Glu?Lys?Ala

25 30 35

gcc?gaa?ctc?gga?tac?att?cct?gat?cga?cga?gcc?caa?aaa?ctt?cgc?caa 259

Ala?Glu?Leu?Gly?Tyr?Ile?Pro?Asp?Arg?Arg?Ala?Gln?Lys?Leu?Arg?Gln

40 45 50

aac?cgc?tcc?gga?ctc?atc?ggt?gtg?gca?ttc?gaa?atg?cac?caa?gca?ttc 307

Asn?Arg?Ser?Gly?Leu?Ile?Gly?Val?Ala?Phe?Glu?Met?His?Gln?Ala?Phe

55 60 65

cac?ggc?gat?atc?gtc?gaa?cac?ctc?tat?ccc?acc?gcc?cga?aaa?cat?ggc 355

His?Gly?Asp?Ile?Val?Glu?His?Leu?Tyr?Pro?Thr?Ala?Arg?Lys?His?Gly

70 75 80 85

ttc?gac?ctg?tac?ctt?agc?gcg?atc?aca?ccg?act?cgc?act?gaa?aaa?gat 403

Phe?Asp?Leu?Tyr?Leu?Ser?Ala?Ile?Thr?Pro?Thr?Arg?Thr?Glu?Lys?Asp

90 95 100

gcc?gtc?aac?gcc?ctg?atc?agg?gaa?cga?tgc?gaa?gca?gta?att?ctt?cta 451

Ala?Val?Asn?Ala?Leu?Ile?Arg?Glu?Arg?Cys?Glu?Ala?Val?Ile?Leu?Leu

105 110 115

gga?tct?cgc?atg?tca?cct?agt?gat?ttg?gaa?aca?atc?gca?cag?caa?ctt 499

Gly?Ser?Arg?Met?Ser?Pro?Ser?Asp?Leu?Glu?Thr?Ile?Ala?Gln?Gln?Leu

120 125 130

ccc?gtc?caa?gta?att?gcc?cgc?ggt?tcc?gga?acc?ccc?aaa?gtc?agt?tcc 547

Pro?Val?Gln?Val?Ile?Ala?Arg?Gly?Ser?Gly?Thr?Pro?Lys?Val?Ser?Ser

135 140 145

gtc?cat?gtc?gac?gac?gca?gtt?ggc?gcc?caa?tta?gcc?ctc?aac?cac?ctc 595

Val?His?Val?Asp?Asp?Ala?Val?Gly?Ala?Gln?Leu?Ala?Leu?Asn?His?Leu

150 155 160 165

atc?gaa?tta?ggc?cac?gaa?cac?atc?atc?tac?atc?gat?ggt?ggc?gac?gcc 643

Ile?Glu?Leu?Gly?His?Glu?His?Ile?Ile?Tyr?Ile?Asp?Gly?Gly?Asp?Ala

170 175 180

cct?ggc?acc?cag?gaa 658

Pro?Gly?Thr?Gln?Glu

185

<210>384

<211>186

<212>PRT

＜213〉Corynebacterium glutamicum

<400>384

Met?Ala?Asp?Val?Ala?Lys?Ala?Ala?Gly?Val?Ser?Thr?Ala?Leu?Val?Ser

1 5 10 15

Ile?Val?Phe?Arg?Asp?Ala?Pro?Gly?Ala?Ser?Glu?Ser?Thr?Arg?Asn?His

20 25 30

Val?Lys?Glu?Lys?Ala?Ala?Glu?Leu?Gly?Tyr?Ile?Pro?Asp?Arg?Arg?Ala

35 40 45

Gln?Lys?Leu?Arg?Gln?Asn?Arg?Ser?Gly?Leu?Ile?Gly?Val?Ala?Phe?Glu

50 55 60

Met?His?Gln?Ala?Phe?His?Gly?Asp?Ile?Val?Glu?His?Leu?Tyr?Pro?Thr

65 70 75 80

Ala?Arg?Lys?His?Gly?Phe?Asp?Leu?Tyr?Leu?Ser?Ala?Ile?Thr?Pro?Thr

85 90 95

Arg?Thr?Glu?Lys?Asp?Ala?Val?Asn?Ala?Leu?Ile?Arg?Glu?Arg?Cys?Glu

100 105 110

Ala?Val?Ile?Leu?Leu?Gly?Ser?Arg?Met?Ser?Pro?Ser?Asp?Leu?Glu?Thr

115 120 125

Ile?Ala?Gln?Gln?Leu?Pro?Val?Gln?Val?Ile?Ala?Arg?Gly?Ser?Gly?Thr

130 135 140

Pro?Lys?Val?Ser?Ser?Val?His?Val?Asp?Asp?Ala?Val?Gly?Ala?Gln?Leu

145 150 155 160

Ala?Leu?Asn?His?Leu?Ile?Glu?Leu?Gly?His?Glu?His?Ile?Ile?Tyr?Ile

165 170 175

Asp?Gly?Gly?Asp?Ala?Pro?Gly?Thr?Gln?Glu

180 185

<210>385

<211>1503

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1480)

<223>RXN01927

<400>385

gagcagcggg?atcttttgcg?taattcgcgc?gcgcagatcc?atgtgattga?ccacaatggt?60

gatgaaattt?tggatacccc?aacggaagag?gatttttaag?atg?gct?ttg?gtt?ctt 115

Met?Ala?Leu?Val?Leu

1 5

gga?atc?gat?agt?tcc?acc?caa?tcc?tgc?aag?gct?ttg?ctt?gtc?gac?gcc 163

Gly?Ile?Asp?Ser?Ser?Thr?Gln?Ser?Cys?Lys?Ala?Leu?Leu?Val?Asp?Ala

10 15 20

gcc?acc?ggc?cag?gtt?atc?gac?gaa?ggc?cgc?gcg?agt?cac?ccg?agc?ggg 211

Ala?Thr?Gly?Gln?Val?Ile?Asp?Glu?Gly?Arg?Ala?Ser?His?Pro?Ser?Gly

25 30 35

tcg?gag?gta?gat?cca?cgt?gcg?tgg?atc?gct?gcg?ctg?gat?caa?gct?acc 259

Ser?Glu?Val?Asp?Pro?Arg?Ala?Trp?Ile?Ala?Ala?Leu?Asp?Gln?Ala?Thr

40 45 50

gag?ggg?ttg?tta?gaa?cgc?gcg?gac?gct?gta?tct?att?gca?ggc?cag?cag 307

Glu?Gly?Leu?Leu?Glu?Arg?Ala?Asp?Ala?Val?Ser?Ile?Ala?Gly?Gln?Gln

55 60 65

cac?ggc?atg?gtg?gcg?ttg?gat?gaa?aac?gat?gaa?atc?gtt?cgc?ccg?gcg 355

His?Gly?Met?Val?Ala?Leu?Asp?Glu?Asn?Asp?Glu?Ile?Val?Arg?Pro?Ala

70 75 80 85

ttg?tta?tgg?aat?gac?act?cgt?tct?gcc?cag?gct?gcg?ttg?gat?ctc?aat 403

Leu?Leu?Trp?Asn?Asp?Thr?Arg?Ser?Ala?Gln?Ala?Ala?Leu?Asp?Leu?Asn

90 95 100

gag?gag?atc?ggc?ggc?gat?cag?gct?gcg?gta?gat?gcc?acg?gga?agt?gtg 451

Glu?Glu?Ile?Gly?Gly?Asp?Gln?Ala?Ala?Val?Asp?Ala?Thr?Gly?Ser?Val

105 110 115

tat?gtt?gct?tct?tta?act?gcc?acc?aaa?atg?cgg?tgg?atg?cgt?gat?cat 499

Tyr?Val?Ala?Ser?Leu?Thr?Ala?Thr?Lys?Met?Arg?Trp?Met?Arg?Asp?His

120 125 130

gaa?cca?gaa?aat?gca?gcg?cgc?acg?gcg?tcg?gtg?atg?ttg?cct?cat?gat 547

Glu?Pro?Glu?Asn?Ala?Ala?Arg?Thr?Ala?Ser?Val?Met?Leu?Pro?His?Asp

135 140 145

ttc?ctc?acc?tgg?cat?ttg?atg?gga?cgc?gga?cgc?aaa?gtc?acc?gac?cat 595

Phe?Leu?Thr?Trp?His?Leu?Met?Gly?Arg?Gly?Arg?Lys?Val?Thr?Asp?His

150 155 160 165

ggt?gat?gct?tct?gga?acg?ggc?tac?tac?agc?acg?cgt?gat?cgt?gcg?tgg 643

Gly?Asp?Ala?Ser?Gly?Thr?Gly?Tyr?Tyr?Ser?Thr?Arg?Asp?Arg?Ala?Trp

170 175 180

cgc?acc?gat?cta?gct?gcc?ttg?gcg?ctg?ggc?cat?gag?gtg?gaa?ctt?cct 691

Arg?Thr?Asp?Leu?Ala?Ala?Leu?Ala?Leu?Gly?His?Glu?Val?Glu?Leu?Pro

185 190 195

gaa?ctc?ctg?gcc?cca?aat?gcg?att?gcg?gga?aca?act?cca?ggt?gga?gtg 739

Glu?Leu?Leu?Ala?Pro?Asn?Ala?Ile?Ala?Gly?Thr?Thr?Pro?Gly?Gly?Val

200 205 210

aaa?gtt?gct?gca?ggc?acg?gga?gat?aat?gct?gcg?gct?gcg?ctt?ggc?ctt 787

Lys?Val?Ala?Ala?Gly?Thr?Gly?Asp?Asn?Ala?Ala?Ala?Ala?Leu?Gly?Leu

215 220 225

gat?ttg?cag?cct?ggt?gat?gtc?agc?gtg?tcg?atc?ggc?acc?tct?ggc?gtt 835

Asp?Leu?Gln?Pro?Gly?Asp?Val?Ser?Val?Ser?Ile?Gly?Thr?Ser?Gly?Val

230 235 240 245

gcc?ggc?atg?acc?gtt?caa?cat?agc?gtc?cac?gat?cca?tct?ggt?ttg?gtc 883

Ala?Gly?Met?Thr?Val?Gln?His?Ser?Val?His?Asp?Pro?Ser?Gly?Leu?Val

250 255 260

act?ggt?ttc?gcc?gat?gcc?acg?ggt?gcg?tat?ttc?ccg?ctg?gcc?tgc?acg 931

Thr?Gly?Phe?Ala?Asp?Ala?Thr?Gly?Ala?Tyr?Phe?Pro?Leu?Ala?Cys?Thr

265 270 275

ctt?aat?ggc?gca?ccg?gtg?ttg?gaa?ttc?ggc?cgc?cgc?att?ctg?ggc?gtg 979

Leu?Asn?Gly?Ala?Pro?Val?Leu?Glu?Phe?Gly?Arg?Arg?Ile?Leu?Gly?Val

280 285 290

gaa?tgg?gaa?gag?ttc?gat?gcg?ctt?gca?ctg?gct?gct?caa?ccc?ggt?tca 1027

Glu?Trp?Glu?Glu?Phe?Asp?Ala?Leu?Ala?Leu?Ala?Ala?Gln?Pro?Gly?Ser

295 300 305

ggt?ggc?gtg?acg?ctc?cag?cct?tat?ttg?gag?ggc?gag?cgt?acg?ccg?aat 1075

Gly?Gly?Val?Thr?Leu?Gln?Pro?Tyr?Leu?Glu?Gly?Glu?Arg?Thr?Pro?Asn

310 315 320 325

cgt?ccc?gca?gca?cgt?ggc?gtt?ttg?gct?gga?cta?aac?tgt?gca?acg?acc 1123

Arg?Pro?Ala?Ala?Arg?Gly?Val?Leu?Ala?Gly?Leu?Asn?Cys?Ala?Thr?Thr

330 335 340

cgc?gag?gac?ttt?gcc?cga?gca?act?gtt?gaa?ggc?ttg?ttg?ttg?gca?ttg 1171

Arg?Glu?Asp?Phe?Ala?Arg?Ala?Thr?Val?Glu?Gly?Leu?Leu?Leu?Ala?Leu

345 350 355

gat?gat?gct?gta?acg?gcg?ctg?gtt?gag?gcc?acg?gga?gtg?ccc?gtt?cag 1219

Asp?Asp?Ala?Val?Thr?Ala?Leu?Val?Glu?Ala?Thr?Gly?Val?Pro?Val?Gln

360 365 370

cgc?atc?cag?ctc?atc?ggt?ggc?ggc?gcg?cgt?tca?cag?gcg?gtt?cgt?gag 1267

Arg?Ile?Gln?Leu?Ile?Gly?Gly?Gly?Ala?Arg?Ser?Gln?Ala?Val?Arg?Glu

375 380 385

att?gcc?cct?gag?att?ttc?ggc?cat?gag?att?gtg?gtt?cca?gaa?ccc?gct 1315

Ile?Ala?Pro?Glu?Ile?Phe?Gly?His?Glu?Ile?Val?Val?Pro?Glu?Pro?Ala

390 395 400 405

gaa?tat?gtg?gcg?ttg?ggt?gca?gct?cgt?cag?gcg?gca?tgg?gcg?ctg?tcg 1363

Glu?Tyr?Val?Ala?Leu?Gly?Ala?Ala?Arg?Gln?Ala?Ala?Trp?Ala?Leu?Ser

410 415 420

ggt?gag?gcc?acg?cca?ccg?cag?tgg?cca?act?ccc?ggt?tcc?gat?ccg?cac 1411

Gly?Glu?Ala?Thr?Pro?Pro?Gln?Trp?Pro?Thr?Pro?Gly?Ser?Asp?Pro?His

425 430 435

cgc?gca?cct?aaa?aac?act?gag?ctg?agc?acg?cgt?tat?gcg?aag?ctg?cgt 1459

Arg?Ala?Pro?Lys?Asn?Thr?Glu?Leu?Ser?Thr?Arg?Tyr?Ala?Lys?Leu?Arg

440 445 450

gct?gca?acg?cag?ggt?tgg?tac?tagagctcga?tattgtcgat?caa 1503

Ala?Ala?Thr?Gln?Gly?Trp?Tyr

455 460

<210>386

<211>460

<212>PRT

＜2 13〉Corynebacterium glutamicum

<400>386

Met?Ala?Leu?Val?Leu?Gly?Ile?Asp?Ser?Ser?Thr?Gln?Ser?Cys?Lys?Ala

1 5 10 15

Leu?Leu?Val?Asp?Ala?Ala?Thr?Gly?Gln?Val?Ile?Asp?Glu?Gly?Arg?Ala

20 25 30

Ser?His?Pro?Ser?Gly?Ser?Glu?Val?Asp?Pro?Arg?Ala?Trp?Ile?Ala?Ala

35 40 45

Leu?Asp?Gln?Ala?Thr?Glu?Gly?Leu?Leu?Glu?Arg?Ala?Asp?Ala?Val?Ser

50 55 60

Ile?Ala?Gly?Gln?Gln?His?Gly?Met?Val?Ala?Leu?Asp?Glu?Asn?Asp?Glu

65 70 75 80

Ile?Val?Arg?Pro?Ala?Leu?Leu?Trp?Asn?Asp?Thr?Arg?Ser?Ala?Gln?Ala

85 90 95

Ala?Leu?Asp?Leu?Asn?Glu?Glu?Ile?Gly?Gly?Asp?Gln?Ala?Ala?Val?Asp

100 105 110

Ala?Thr?Gly?Ser?Val?Tyr?Val?Ala?Ser?Leu?Thr?Ala?Thr?Lys?Met?Arg

115 120 125

Trp?Met?Arg?Asp?His?Glu?Pro?Glu?Asn?Ala?Ala?Arg?Thr?Ala?Ser?Val

130 135 140

Met?Leu?Pro?His?Asp?Phe?Leu?Thr?Trp?His?Leu?Met?Gly?Arg?Gly?Arg

145 150 155 160

Lys?Val?Thr?Asp?His?Gly?Asp?Ala?Ser?Gly?Thr?Gly?Tyr?Tyr?Ser?Thr

165 170 175

Arg?Asp?Arg?Ala?Trp?Arg?Thr?Asp?Leu?Ala?Ala?Leu?Ala?Leu?Gly?His

180 185 190

Glu?Val?Glu?Leu?Pro?Glu?Leu?Leu?Ala?Pro?Asn?Ala?Ile?Ala?Gly?Thr

195 200 205

Thr?Pro?Gly?Gly?Val?Lys?Val?Ala?Ala?Gly?Thr?Gly?Asp?Asn?Ala?Ala

210 215 220

Ala?Ala?Leu?Gly?Leu?Asp?Leu?Gln?Pro?Gly?Asp?Val?Ser?Val?Ser?Ile

225 230 235 240

Gly?Thr?Ser?Gly?Val?Ala?Gly?Met?Thr?Val?Gln?His?Ser?Val?His?Asp

245 250 255

Pro?Ser?Gly?Leu?Val?Thr?Gly?Phe?Ala?Asp?Ala?Thr?Gly?Ala?Tyr?Phe

260 265 270

Pro?Leu?Ala?Cys?Thr?Leu?Asn?Gly?Ala?Pro?Val?Leu?Glu?Phe?Gly?Arg

275 280 285

Arg?Ile?Leu?Gly?Val?Glu?Trp?Glu?Glu?Phe?Asp?Ala?Leu?Ala?Leu?Ala

290 295 300

Ala?Gln?Pro?Gly?Ser?Gly?Gly?Val?Thr?Leu?Gln?Pro?Tyr?Leu?Glu?Gly

305 310 315 320

Glu?Arg?Thr?Pro?Asn?Arg?Pro?Ala?Ala?Arg?Gly?Val?Leu?Ala?Gly?Leu

325 330 335

Asn?Cys?Ala?Thr?Thr?Arg?Glu?Asp?Phe?Ala?Arg?Ala?Thr?Val?Glu?Gly

340 345 350

Leu?Leu?Leu?Ala?Leu?Asp?Asp?Ala?Val?Thr?Ala?Leu?Val?Glu?Ala?Thr

355 360 365

Gly?Val?Pro?Val?Gln?Arg?Ile?Gln?Leu?Ile?Gly?Gly?Gly?Ala?Arg?Ser

370 375 380

Gln?Ala?Val?Arg?Glu?Ile?Ala?Pro?Glu?Ile?Phe?Gly?His?Glu?Ile?Val

385 390 395 400

Val?Pro?Glu?Pro?Ala?Glu?Tyr?Val?Ala?Leu?Gly?Ala?Ala?Arg?Gln?Ala

405 410 415

Ala?Trp?Ala?Leu?Ser?Gly?Glu?Ala?Thr?Pro?Pro?Gln?Trp?Pro?Thr?Pro

420 425 430

Gly?Ser?Asp?Pro?His?Arg?Ala?Pro?Lys?Asn?Thr?Glu?Leu?Ser?Thr?Arg

435 440 445

Tyr?Ala?Lys?Leu?Arg?Ala?Ala?Thr?Gln?Gly?Trp?Tyr

450 455 460

<210>387

<211>1139

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(1116)

<223>FRXA01927

<400>387

aat?gac?act?cgt?tct?gcc?cag?gct?gcg?ttg?gat?ctc?aat?gag?gag?atc 48

Asn?Asp?Thr?Arg?Ser?Ala?Gln?Ala?Ala?Leu?Asp?Leu?Asn?Glu?Glu?Ile

1 5 10 15

ggc?ggc?gat?cag?gct?gcg?gta?gat?gcc?acg?gga?agt?gtg?tat?gtt?gct 96

Gly?Gly?Asp?Gln?Ala?Ala?Val?Asp?Ala?Thr?Gly?Ser?Val?Tyr?Val?Ala

20 25 30

tct?tta?act?gcc?acc?aaa?atg?cgg?tgg?atg?cgt?gat?cat?gaa?cca?gaa 144

Ser?Leu?Thr?Ala?Thr?Lys?Met?Arg?Trp?Met?Arg?Asp?His?Glu?Pro?Glu

35 40 45

aat?gca?gcg?cgc?acg?gcg?tcg?gtg?atg?ttg?cct?cat?gat?ttc?ctc?acc 192

Asn?Ala?Ala?Arg?Thr?Ala?Ser?Val?Met?Leu?Pro?His?Asp?Phe?Leu?Thr

50 55 60

tgg?cat?ttg?atg?gga?cgc?gga?cgc?aaa?gtc?acc?gac?cat?ggt?gat?gct 240

Trp?His?Leu?Met?Gly?Arg?Gly?Arg?Lys?Val?Thr?Asp?His?Gly?Asp?Ala

65 70 75 80

tct?gga?acg?ggc?tac?tac?agc?acg?cgt?gat?cgt?gcg?tgg?cgc?acc?gat 288

Ser?Gly?Thr?Gly?Tyr?Tyr?Ser?Thr?Arg?Asp?Arg?Ala?Trp?Arg?Thr?Asp

85 90 95

cta?gct?gcc?ttg?gcg?ctg?ggc?cat?gag?gtg?gaa?ctt?cct?gaa?ctc?ctg 336

Leu?Ala?Ala?Leu?Ala?Leu?Gly?His?Glu?Val?Glu?Leu?Pro?Glu?Leu?Leu

100 105 110

gcc?cca?aat?gcg?att?gcg?gga?aca?act?cca?ggt?gga?gtg?aaa?gtt?gct 384

Ala?Pro?Asn?Ala?Ile?Ala?Gly?Thr?Thr?Pro?Gly?Gly?Val?Lys?Val?Ala

115 120 125

gca?ggc?acg?gga?gat?aat?gct?gcg?gct?gcg?ctt?ggc?ctt?gat?ttg?cag 432

Ala?Gly?Thr?Gly?Asp?Asn?Ala?Ala?Ala?Ala?Leu?Gly?Leu?Asp?Leu?Gln

130 135 140

cct?ggt?gat?gtc?agc?gtg?tcg?atc?ggc?acc?tct?ggc?gtt?gcc?ggc?atg 480

Pro?Gly?Asp?Val?Ser?Val?Ser?Ile?Gly?Thr?Ser?Gly?Val?Ala?Gly?Met

145 150 155 160

acc?gtt?caa?cat?agc?gtc?cac?gat?cca?tct?ggt?ttg?gtc?act?ggt?ttc 528

Thr?Val?Gln?His?Ser?Val?His?Asp?Pro?Ser?Gly?Leu?Val?Thr?Gly?Phe

165 170 175

gcc?gat?gcc?acg?ggt?gcg?tat?ttc?ccg?ctg?gcc?tgc?acg?ctt?aat?ggc 576

Ala?Asp?Ala?Thr?Gly?Ala?Tyr?Phe?Pro?Leu?Ala?Cys?Thr?Leu?Asn?Gly

180 185 190

gca?ccg?gtg?ttg?gaa?ttc?ggc?cgc?cgc?att?ctg?ggc?gtg?gaa?tgg?gaa 624

Ala?Pro?Val?Leu?Glu?Phe?Gly?Arg?Arg?Ile?Leu?Gly?Val?Glu?Trp?Glu

195 200 205

gag?ttc?gat?gcg?ctt?gca?ctg?gct?gct?caa?ccc?ggt?tca?ggt?ggc?gtg 672

Glu?Phe?Asp?Ala?Leu?Ala?Leu?Ala?Ala?Gln?Pro?Gly?Ser?Gly?Gly?Val

210 215 220

acg?ctc?cag?cct?tat?ttg?gag?ggc?gag?cgt?acg?ccg?aat?cgt?ccc?gca 720

Thr?Leu?Gln?Pro?Tyr?Leu?Glu?Gly?Glu?Arg?Thr?Pro?Asn?Arg?Pro?Ala

225 230 235 240

gca?cgt?ggc?gtt?ttg?gct?gga?cta?aac?tgt?gca?acg?acc?cgc?gag?gac 768

Ala?Arg?Gly?Val?Leu?Ala?Gly?Leu?Asn?Cys?Ala?Thr?Thr?Arg?Glu?Asp

245 250 255

ttt?gcc?cga?gca?act?gtt?gaa?ggc?ttg?ttg?ttg?gca?ttg?gat?gat?gct 816

Phe?Ala?Arg?Ala?Thr?Val?Glu?Gly?Leu?Leu?Leu?Ala?Leu?Asp?Asp?Ala

260 265 270

gta?acg?gcg?ctg?gtt?gag?gcc?acg?gga?gtg?ccc?gtt?cag?cgc?atc?cag 864

Val?Thr?Ala?Leu?Val?Glu?Ala?Thr?Gly?Val?Pro?Val?Gln?Arg?Ile?Gln

275 280 285

ctc?atc?ggt?ggc?ggc?gcg?cgt?tca?cag?gcg?gtt?cgt?gag?att?gcc?cct 912

Leu?Ile?Gly?Gly?Gly?Ala?Arg?Ser?Gln?Ala?Val?Arg?Glu?Ile?Ala?Pro

290 295 300

gag?att?ttc?ggc?cat?gag?att?gtg?gtt?cca?gaa?ccc?gct?gaa?tat?gtg 960

Glu?Ile?Phe?Gly?His?Glu?Ile?Val?Val?Pro?Glu?Pro?Ala?Glu?Tyr?Val

305 310 315 320

gcg?ttg?ggt?gca?gct?cgt?cag?gcg?gca?tgg?gcg?ctg?tcg?ggt?gag?gcc 1008

Ala?Leu?Gly?Ala?Ala?Arg?Gln?Ala?Ala?Trp?Ala?Leu?Ser?Gly?Glu?Ala

325 330 335

acg?cca?ccg?cag?tgg?cca?act?ccc?ggt?tcc?gat?ccg?cac?cgc?gca?cct 1056

Thr?Pro?Pro?Gln?Trp?Pro?Thr?Pro?Gly?Ser?Asp?Pro?His?Arg?Ala?Pro

340 345 350

aaa?aac?act?gag?ctg?agc?acg?cgt?tat?gcg?aag?ctg?cgt?gct?gca?acg 1104

Lys?Asn?Thr?Glu?Leu?Ser?Thr?Arg?Tyr?Ala?Lys?Leu?Arg?Ala?Ala?Thr

355 360 365

cag?ggt?tgg?tac?tagagctcga?tattgtcgat?caa 1139

Gln?Gly?Trp?Tyr

370

<210>388

<211>372

<212>PRT

＜213〉Corynebacterium glutamicum

<400>388

Asn?Asp?Thr?Arg?Ser?Ala?Gln?Ala?Ala?Leu?Asp?Leu?Asn?Glu?Glu?Ile

1 5 10 15

Gly?Gly?Asp?Gln?Ala?Ala?Val?Asp?Ala?Thr?Gly?Ser?Val?Tyr?Val?Ala

20 25 30

Ser?Leu?Thr?Ala?Thr?Lys?Met?Arg?Trp?Met?Arg?Asp?His?Glu?Pro?Glu

35 40 45

Asn?Ala?Ala?Arg?Thr?Ala?Ser?Val?Met?Leu?Pro?His?Asp?Phe?Leu?Thr

50 55 60

Trp?His?Leu?Met?Gly?Arg?Gly?Arg?Lys?Val?Thr?Asp?His?Gly?Asp?Ala

65 70 75 80

Ser?Gly?Thr?Gly?Tyr?Tyr?Ser?Thr?Arg?Asp?Arg?Ala?Trp?Arg?Thr?Asp

85 90 95

Leu?Ala?Ala?Leu?Ala?Leu?Gly?His?Glu?Val?Glu?Leu?Pro?Glu?Leu?Leu

100 105 110

Ala?Pro?Asn?Ala?Ile?Ala?Gly?Thr?Thr?Pro?Gly?Gly?Val?Lys?Val?Ala

115 120 125

Ala?Gly?Thr?Gly?Asp?Asn?Ala?Ala?Ala?Ala?Leu?Gly?Leu?Asp?Leu?Gln

130 135 140

Pro?Gly?Asp?Val?Ser?Val?Ser?Ile?Gly?Thr?Ser?Gly?Val?Ala?Gly?Met

145 150 155 160

Thr?Val?Gln?His?Ser?Val?His?Asp?Pro?Ser?Gly?Leu?Val?Thr?Gly?Phe

165 170 175

Ala?Asp?Ala?Thr?Gly?Ala?Tyr?Phe?Pro?Leu?Ala?Cys?Thr?Leu?Asn?Gly

180 185 190

Ala?Pro?Val?Leu?Glu?Phe?Gly?Arg?Arg?Ile?Leu?Gly?Val?Glu?Trp?Glu

195 200 205

Glu?Phe?Asp?Ala?Leu?Ala?Leu?Ala?Ala?Gln?Pro?Gly?Ser?Gly?Gly?Val

210 215 220

Thr?Leu?Gln?Pro?Tyr?Leu?Glu?Gly?Glu?Arg?Thr?Pro?Asn?Arg?Pro?Ala

225 230 235 240

Ala?Arg?Gly?Val?Leu?Ala?Gly?Leu?Asn?Cys?Ala?Thr?Thr?Arg?Glu?Asp

245 250 255

Phe?Ala?Arg?Ala?Thr?Val?Glu?Gly?Leu?Leu?Leu?Ala?Leu?Asp?Asp?Ala

260 265 270

Val?Thr?Ala?Leu?Val?Glu?Ala?Thr?Gly?Val?Pro?Val?Gln?Arg?Ile?Gln

275 280 285

Leu?Ile?Gly?Gly?Gly?Ala?Arg?Ser?Gln?Ala?Val?Arg?Glu?Ile?Ala?Pro

290 295 300

Glu?lle?Phe?Gly?His?Glu?Ile?Val?Val?Pro?Glu?Pro?Ala?Glu?Tyr?Val

305 310 315 320

Ala?Leu?Gly?Ala?Ala?Arg?Gln?Ala?Ala?Trp?Ala?Leu?Ser?Gly?Glu?Ala

325 330 335

Thr?Pro?Pro?Gln?Trp?Pro?Thr?Pro?Gly?Ser?Asp?Pro?His?Arg?Ala?Pro

340 345 350

Lys?Asn?Thr?Glu?Leu?Ser?Thr?Arg?Tyr?Ala?Lys?Leu?Arg?Ala?Ala?Thr

355 360 365

Gln?Gly?Trp?Tyr

370

<210>389

<211>844

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(844)

<223>RXA02729

<400>389

gaattaattg?caggcacggt?acctagcgtg?acgaaaacta?cgatccccac?tgcccttatt?60

catcgtgaat?caatcatcaa?ctccacttta?aggaagaagg?atg?gac?tcc?cca?atg 115

Met?Asp?Ser?Pro?Met

1 5

agt?aac?tca?acc?ggt?acc?gac?att?gtc?gtt?gtc?gga?tcc?atc?aat?gcc 163

Ser?Asn?Ser?Thr?Gly?Thr?Asp?Ile?Val?Val?Val?Gly?Ser?Ile?Asn?Ala

10 15 20

gat?ctc?acc?gca?aaa?gtt?caa?cgc?cac?cct?gaa?cct?gga?gaa?acc?ctc 211

Asp?Leu?Thr?Ala?Lys?Val?Gln?Arg?His?Pro?Glu?Pro?Gly?Glu?Thr?Leu

25 30 35

ctg?ggt?agc?ggc?ggc?aca?gtg?agt?gct?ggt?ggc?aaa?ggc?gcc?aac?caa 259

Leu?Gly?Ser?Gly?Gly?Thr?Val?Ser?Ala?Gly?Gly?Lys?Gly?Ala?Asn?Gln

40 45 50

gct?gtg?gcg?gca?gcg?caa?tta?ggt?gcc?aaa?gtc?acc?atg?atc?ggt?gcg 307

Ala?Val?Ala?Ala?Ala?Gln?Leu?Gly?Ala?Lys?Val?Thr?Met?Ile?Gly?Ala

55 60 65

gtc?gga?acc?gat?caa?atg?gct?ggc?gag?gcg?ctg?aca?cat?ttg?cgt?caa 355

Val?Gly?Thr?Asp?Gln?Met?Ala?Gly?Glu?Ala?Leu?Thr?His?Leu?Arg?Gln

70 75 80 85

tca?gga?gca?gat?atg?tcc?gcg?att?gcc?act?gtg?gac?ggt?ccc?act?ggt 403

Ser?Gly?Ala?Asp?Met?Ser?Ala?Ile?Ala?Thr?Val?Asp?Gly?Pro?Thr?Gly

90 95 100

ctt?gcc?atc?atc?act?gtg?tct?gac?gat?ggg?gaa?aac?acc?atc?atc?gtt 451

Leu?Ala?Ile?Ile?Thr?Val?Ser?Asp?Asp?Gly?Glu?Asn?Thr?Ile?Ile?Val

105 110 115

atc?cct?ggc?gct?aac?gct?tct?gtc?acc?gcg?gaa?ttt?gtt?gat?aaa?cac 499

Ile?Pro?Gly?Ala?Asn?Ala?Ser?Val?Thr?Ala?Glu?Phe?Val?Asp?Lys?His

120 125 130

tcc?caa?ctc?att?gag?aac?gcc?ggc?att?gtg?ttg?ctt?cag?ggt?gag?atc 547

Ser?Gln?Leu?Ile?Glu?Asn?Ala?Gly?Ile?Val?Leu?Leu?Gln?Gly?Glu?Ile

135 140 145

cct?gcc?gat?ggt?ttc?gag?cgt?gcc?gtt?gat?ctt?tca?caa?gga?cgt?gtg 595

Pro?Ala?Asp?Gly?Phe?Glu?Arg?Ala?Val?Asp?Leu?Ser?Gln?Gly?Arg?Val

150 155 160 165

gtg?atc?aat?ctg?gct?cca?gtt?gtg?ccc?gtg?gga?cat?gat?cag?ctg?cgt 643

Val?Ile?Asn?Leu?Ala?Pro?Val?Val?Pro?Val?Gly?His?Asp?Gln?Leu?Arg

170 175 180

cgt?gcc?gat?cca?ttg?ctg?gtc?aac?gaa?cac?gaa?ggc?gct?ctg?gtg?ctg 691

Arg?Ala?Asp?Pro?Leu?Leu?Val?Asn?Glu?His?Glu?Gly?Ala?Leu?Val?Leu

185 190 195

gac?atg?ctt?gga?act?cca?gcg?acc?acg?tct?gat?ccc?caa?agt?ttg?gtc 739

Asp?Met?Leu?Gly?Thr?Pro?Ala?Thr?Thr?Ser?Asp?Pro?Gln?Ser?Leu?Val

200 205 210

act?gaa?ttg?ctg?gag?cag?ggt?ttt?act?tcc?gtg?gtg?atg?aca?ctt?ggt 787

Thr?Glu?Leu?Leu?Glu?Gln?Gly?Phe?Thr?Ser?Val?Val?Met?Thr?Leu?Gly

215 220 225

gcc?gaa?ggt?gct?ctg?gtt?ggc?acg?ccg?ggc?caa?ctc?acg?gca?att?cct 835

Ala?Glu?Gly?Ala?Leu?Val?Gly?Thr?Pro?Gly?Gln?Leu?Thr?Ala?Ile?Pro

230 235 240 245

acc?cca?aag 844

Thr?Pro?Lys

<210>390

<211>248

<212>PRT

＜213〉Corynebacterium glutamicum

<400>390

Met?Asp?Ser?Pro?Met?Ser?Asn?Ser?Thr?Gly?Thr?Asp?Ile?Val?Val?Val

1 5 10 15

Gly?Ser?Ile?Asn?Ala?Asp?Leu?Thr?Ala?Lys?Val?Gln?Arg?His?Pro?Glu

20 25 30

Pro?Gly?Glu?Thr?Leu?Leu?Gly?Ser?Gly?Gly?Thr?Val?Ser?Ala?Gly?Gly

35 40 45

Lys?Gly?Ala?Asn?Gln?Ala?Val?Ala?Ala?Ala?Gln?Leu?Gly?Ala?Lys?Val

50 55 60

Thr?Met?Ile?Gly?Ala?Val?Gly?Thr?Asp?Gln?Met?Ala?Gly?Glu?Ala?Leu

65 70 75 80

Thr?His?Leu?Arg?Gln?Ser?Gly?Ala?Asp?Met?Ser?Ala?Ile?Ala?Thr?Val

85 90 95

Asp?Gly?Pro?Thr?Gly?Leu?Ala?Ile?Ile?Thr?Val?Ser?Asp?Asp?Gly?Glu

100 105 110

Asn?Thr?Ile?Ile?Val?Ile?Pro?Gly?Ala?Asn?Ala?Ser?Val?Thr?Ala?Glu

115 120 125

Phe?Val?Asp?Lys?His?Ser?Gln?Leu?Ile?Glu?Asn?Ala?Gly?Ile?Val?Leu

130 135 140

Leu?Gln?Gly?Glu?Ile?Pro?Ala?Asp?Gly?Phe?Glu?Arg?Ala?Val?Asp?Leu

145 150 155 160

Ser?Gln?Gly?Arg?Val?Val?Ile?Asn?Leu?Ala?Pro?Val?Val?Pro?Val?Gly

165 170 175

His?Asp?Gln?Leu?Arg?Arg?Ala?Asp?Pro?Leu?Leu?Val?Asn?Glu?His?Glu

180 185 190

Gly?Ala?Leu?Val?Leu?Asp?Met?Leu?Gly?Thr?Pro?Ala?Thr?Thr?Ser?Asp

195 200 205

Pro?Gln?Ser?Leu?Val?Thr?Glu?Leu?Leu?Glu?Gln?Gly?Phe?Thr?Ser?Val

210 215 220

Val?Met?Thr?Leu?Gly?Ala?Glu?Gly?Ala?Leu?Val?Gly?Thr?Pro?Gly?Gln

225 230 235 240

Leu?Thr?Ala?Ile?Pro?Thr?Pro?Lys

245

<210>391

<211>1026

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>101)..(1003)

<223>RXA02797

<400>391

acagtctcat?gaagccataa?taaccacctt?ctacaaagat?cgacgtagaa?tggaataacc?60

ccttatgaaa?acgtttgcat?aactccgcta?aggatgttcc?atg?aat?aat?cga?att 115

Met?Asn?Asn?Arg?Ile

1 5

gtc?gta?gtc?ggc?tcc?atc?aac?gct?gat?ctt?aat?gtt?ctc?gtt?gac?cgc 163

Val?Val?Val?Gly?Ser?Ile?Asn?Ala?Asp?Leu?Asn?Val?Leu?Val?Asp?Arg

10 15 20

cac?cca?gca?cct?ggc?gaa?aca?ctg?ttg?ggc?agt?ggt?gga?cac?atc?act 211

His?Pro?Ala?Pro?Gly?Glu?Thr?Leu?Leu?Gly?Ser?Gly?Gly?His?Ile?Thr

25 30 35

gca?gga?ggc?aaa?ggc?gcc?aac?cag?gca?gta?gct?gcc?gct?ctt?caa?ggt 259

Ala?Gly?Gly?Lys?Gly?Ala?Asn?Gln?Ala?Val?Ala?Ala?Ala?Leu?Gln?Gly

40 45 50

gca?gac?gtc?gcc?ttt?gtc?ggc?gct?gtg?ggc?aag?gat?cct?tac?gct?gcc 307

Ala?Asp?Val?Ala?Phe?Val?Gly?Ala?Val?Gly?Lys?Asp?Pro?Tyr?Ala?Ala

55 60 65

cca?gcc?tta?gaa?ttc?ctt?cgt?tcg?tca?ggc?gtc?gac?ctt?acg?gca?gta 355

Pro?Ala?Leu?Glu?Phe?Leu?Arg?Ser?Ser?Gly?Val?Asp?Leu?Thr?Ala?Val

70 75 80 85

tcc?gaa?gta?gat?gac?acc?acc?ggg?ctt?gca?gtt?atc?acc?gtt?gcc?aaa 403

Ser?Glu?Val?Asp?Asp?Thr?Thr?Gly?Leu?Ala?Val?Ile?Thr?Val?Ala?Lys

90 95 100

gac?ggc?gag?aac?aat?atc?gtt?gtc?atc?ccc?ggc?gcg?aat?tcc?ctg?gtc 451

Asp?Gly?Glu?Asn?Asn?Ile?Val?Val?Ile?Pro?Gly?Ala?Asn?Ser?Leu?Val

105 110 115

aat?tgt?gat?tat?gta?agc?agc?caa?tcc?gct?ctt?tta?gct?gaa?gct?gga 499

Asn?Cys?Asp?Tyr?Val?Ser?Ser?Gln?Ser?Ala?Leu?Leu?Ala?Glu?Ala?Gly

120 125 130

atc?ctg?ttg?ctg?caa?ggt?gag?atc?cct?gcg?gat?ggc?ttc?aaa?gag?gcc 547

Ile?Leu?Leu?Leu?Gln?Gly?Glu?Ile?Pro?Ala?Asp?Gly?Phe?Lys?Glu?Ala

135 140 145

att?cac?cac?acc?atg?ggt?cgc?gtc?gtg?gtg?aat?cta?gcg?ccc?gtc?atc 595

Ile?His?His?Thr?Met?Gly?Arg?Val?Val?Val?Asn?Leu?Ala?Pro?Val?Ile

150 155 160 165

gag?gta?gag?aag?tcc?gcg?tta?ctt?gag?gct?gat?ccg?atc?atc?gcc?aat 643

Glu?Val?Glu?Lys?Ser?Ala?Leu?Leu?Glu?Ala?Asp?Pro?Ile?Ile?Ala?Asn

170 175 180

gag?cac?gag?gcc?ggc?ctg?att?ctg?gat?caa?ttc?ggg?gca?ggc?atc?gat 691

Glu?His?Glu?Ala?Gly?Leu?Ile?Leu?Asp?Gln?Phe?Gly?Ala?Gly?Ile?Asp

185 190 195

tcc?atg?gat?ccc?cac?gag?ctc?gcg?caa?gct?ctc?ctc?gac?gcc?ggt?ttc 739

Ser?Met?Asp?Pro?His?Glu?Leu?Ala?Gln?Ala?Leu?Leu?Asp?Ala?Gly?Phe

200 205 210

gcc?tct?gtt?gtt?tta?acg?ctt?gga?tcc?gca?ggc?gcg?ttg?gtc?gcc?gat 787

Ala?Ser?Val?Val?Leu?Thr?Leu?Gly?Ser?Ala?Gly?Ala?Leu?Val?Ala?Asp

215 220 225

gcc?acc?ggt?atc?acg?gac?atc?gcc?aca?cca?acg?gtg?cag?gca?gtt?gac 835

Ala?Thr?Gly?Ile?Thr?Asp?Ile?Ala?Thr?Pro?Thr?Val?Gln?Ala?Val?Asp

230 235 240 245

acc?acg?gga?gcc?ggt?gac?gct?ttt?gcc?gga?gcc?ttc?tgc?gca?cga?cta 883

Thr?Thr?Gly?Ala?Gly?Asp?Ala?Phe?Ala?Gly?Ala?Phe?Cys?Ala?Arg?Leu

250 255 260

att?aaa?ggc?gat?tcg?ctt?atc?gac?gcc?gcc?acc?cac?gca?gca?cgc?gtc 931

Ile?Lys?Gly?Asp?Ser?Leu?Ile?Asp?Ala?Ala?Thr?His?Ala?Ala?Arg?Val

265 270 275

ggc?gct?tac?tcg?gtg?caa?acc?gcc?gga?gcg?caa?gcg?tcc?tat?ccg?gac 979

Gly?Ala?Tyr?Ser?Val?Gln?Thr?Ala?Gly?Ala?Gln?Ala?Ser?Tyr?Pro?Asp

280 285 290

gcg?agc?gtt?tca?ctt?ccc?tct?gtt?taaaaaaact?atttaagaag?agg 1026

Ala?Ser?Val?Ser?Leu?Pro?Ser?Val

295 300

<210>392

<211>301

<212>PRT

＜213〉Corynebacterium glutamicum

<400>392

Met?Asn?Asn?Arg?Ile?Val?Val?Val?Gly?Ser?Ile?Asn?Ala?Asp?Leu?Asn

1 5 10 15

Val?Leu?Val?Asp?Arg?His?Pro?Ala?Pro?Gly?Glu?Thr?Leu?Leu?Gly?Ser

20 25 30

Gly?Gly?His?Ile?Thr?Ala?Gly?Gly?Lys?Gly?Ala?Asn?Gln?Ala?Val?Ala

35 40 45

Ala?Ala?Leu?Gln?Gly?Ala?Asp?Val?Ala?Phe?Val?Gly?Ala?Val?Gly?Lys

50 55 60

Asp?Pro?Tyr?Ala?Ala?Pro?Ala?Leu?Glu?Phe?Leu?Arg?Ser?Ser?Gly?Val

65 70 75 80

Asp?Leu?Thr?Ala?Val?Ser?Glu?Val?Asp?Asp?Thr?Thr?Gly?Leu?Ala?Val

85 90 95

Ile?Thr?Val?Ala?Lys?Asp?Gly?Glu?Asn?Asn?Ile?Val?Val?Ile?Pro?Gly

100 105 110

Ala?Asn?Ser?Leu?Val?Asn?Cys?Asp?Tyr?Val?Ser?Ser?Gln?Ser?Ala?Leu

115 120 125

Leu?Ala?Glu?Ala?Gly?Ile?Leu?Leu?Leu?Gln?Gly?Glu?Ile?Pro?Ala?Asp

130 135 140

Gly?Phe?Lys?Glu?Ala?Ile?His?His?Thr?Met?Gly?Arg?Val?Val?Val?Asn

145 150 155 160

Leu?Ala?Pro?Val?Ile?Glu?Val?Glu?Lys?Ser?Ala?Leu?Leu?Glu?Ala?Asp

165 170 175

Pro?Ile?Ile?Ala?Asn?Glu?His?Glu?Ala?Gly?Leu?Ile?Leu?Asp?Gln?Phe

180 185 190

Gly?Ala?Gly?Ile?Asp?Ser?Met?Asp?Pro?His?Glu?Leu?Ala?Gln?Ala?Leu

195 200 205

Leu?Asp?Ala?Gly?Phe?Ala?Ser?Val?Val?Leu?Thr?Leu?Gly?Ser?Ala?Gly

210 215 220

Ala?Leu?Val?Ala?Asp?Ala?Thr?Gly?Ile?Thr?Asp?Ile?Ala?Thr?Pro?Thr

225 230 235 240

Val?Gln?Ala?Val?Asp?Thr?Thr?Gly?Ala?Gly?Asp?Ala?Phe?Ala?Gly?Ala

245 250 255

Phe?Cys?Ala?Arg?Leu?Ile?Lys?Gly?Asp?Ser?Leu?Ile?Asp?Ala?Ala?Thr

260 265 270

His?Ala?Ala?Arg?Val?Gly?Ala?Tyr?Ser?Val?Gln?Thr?Ala?Gly?Ala?Gln

275 280 285

Ala?Ser?Tyr?Pro?Asp?Ala?Ser?Val?Ser?Leu?Pro?Ser?Val

290 295 300

<210>393

<211>1161

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1138)

<223>RXA02730

<400>393

ccaacatcgc?cttgcacgta?ataggttaaa?acacaagtga?atgtaatcgt?ttgcagcaat?60

cgattacata?aaggtagata?atgagataaa?gcgaggcgct?atg?gcg?acg?gaa?aaa 115

Met?Ala?Thr?Glu?Lys

1 5

ttc?cga?ccg?act?ctt?aaa?gat?gtc?gct?cgt?caa?gca?ggt?gtc?tcc?atc 163

Phe?Arg?Pro?Thr?Leu?Lys?Asp?Val?Ala?Arg?Gln?Ala?Gly?Val?Ser?Ile

10 15 20

gcc?aca?gca?tca?cga?gca?cta?gcg?gat?aat?ccg?gcg?gtt?gct?gca?tcg 211

Ala?Thr?Ala?Ser?Arg?Ala?Leu?Ala?Asp?Asn?Pro?Ala?Val?Ala?Ala?Ser

25 30 35

act?cgt?gaa?aga?atc?caa?caa?tta?gcc?tct?gat?ctg?ggt?tac?cgg?gcc 259

Thr?Arg?Glu?Arg?Ile?Gln?Gln?Leu?Ala?Ser?Asp?Leu?Gly?Tyr?Arg?Ala

40 45 50

aat?gct?caa?gct?cgt?gcg?ctt?cgc?agt?tct?cgc?agc?aac?acc?att?ggt 307

Asn?Ala?Gln?Ala?Arg?Ala?Leu?Arg?Ser?Ser?Arg?Ser?Asn?Thr?Ile?Gly

55 60 65

gtg?att?gtt?ccc?agt?ttg?att?aac?cat?tac?ttc?gcc?gca?atg?gtt?act 355

Val?Ile?Val?Pro?Ser?Leu?Ile?Asn?His?Tyr?Phe?Ala?Ala?Met?Val?Thr

70 75 80 85

gaa?att?caa?agc?acc?gcc?agc?aaa?gct?gga?ctt?gcc?acg?att?atc?acc 403

Glu?Ile?Gln?Ser?Thr?Ala?Ser?Lys?Ala?Gly?Leu?Ala?Thr?Ile?Ile?Thr

90 95 100

aac?agc?aat?gaa?gat?gcg?acc?act?atg?tct?ggg?tct?ttg?gag?ttt?ctc 451

Asn?Ser?Asn?Glu?Asp?Ala?Thr?Thr?Met?Ser?Gly?Ser?Leu?Glu?Phe?Leu

105 110 115

acc?tcg?cat?ggt?gtc?gat?gga?atc?atc?tgc?gta?cct?aat?gag?gaa?tgc 499

Thr?Ser?His?Gly?Val?Asp?Gly?Ile?Ile?Cys?Val?Pro?Asn?Glu?Glu?Cys

120 125 130

gcg?aat?caa?cta?gag?gac?ttg?cag?aag?caa?gga?atg?cca?gtg?gtg?ttg 547

Ala?Asn?Gln?Leu?Glu?Asp?Leu?Gln?Lys?Gln?Gly?Met?Pro?Val?Val?Leu

135 140 145

gtt?gac?cga?gag?ctt?cca?gga?gac?tcc?acc?atc?cca?acg?gcg?acc?tct 595

Val?Asp?Arg?Glu?Leu?Pro?Gly?Asp?Ser?Thr?Ile?Pro?Thr?Ala?Thr?Ser

150 155 160 165

aac?ccc?caa?cca?gga?atc?gcc?gca?gca?gta?gaa?ctc?ctg?gct?cac?aac 643

Asn?Pro?Gln?Pro?Gly?Ile?Ala?Ala?Ala?Val?Glu?Leu?Leu?Ala?His?Asn

170 175 180

aac?gcg?ttg?ccg?att?ggt?tac?ctc?tca?ggt?ccc?atg?gac?acc?tca?aca 691

Asn?Ala?Leu?Pro?Ile?Gly?Tyr?Leu?Ser?Gly?Pro?Met?Asp?Thr?Ser?Thr

185 190 195

ggt?aga?gag?cga?tta?gag?gat?ttc?aaa?gca?gcc?tgc?gcc?aac?tcc?aaa 739

Gly?Arg?Glu?Arg?Leu?Glu?Asp?Phe?Lys?Ala?Ala?Cys?Ala?Asn?Ser?Lys

200 205 210

att?ggc?gaa?cag?ctc?gtt?ttt?ctg?ggt?ggg?tac?gaa?caa?agc?gtt?gga 787

Ile?Gly?Glu?Gln?Leu?Val?Phe?Leu?Gly?Gly?Tyr?Glu?Gln?Ser?Val?Gly

215 220 225

ttt?gaa?ggc?gct?acg?aaa?ttg?ctc?gat?caa?gga?gct?aaa?act?ctt?ttt 835

Phe?Glu?Gly?Ala?Thr?Lys?Leu?Leu?Asp?Gln?Gly?Ala?Lys?Thr?Leu?Phe

230 235 240 245

gcc?ggc?gat?tct?atg?atg?acg?atc?ggt?gtc?att?gaa?gcc?tgc?cat?aag 883

Ala?Gly?Asp?Ser?Met?Met?Thr?Ile?Gly?Val?Ile?Glu?Ala?Cys?His?Lys

250 255 260

gct?ggt?ttg?gtt?atc?ggc?aag?gat?gtc?agc?gtg?att?ggt?ttt?gat?aca 931

Ala?Gly?Leu?Val?Ile?Gly?Lys?Asp?Val?Ser?Val?Ile?Gly?Phe?Asp?Thr

265 270 275

cat?ccg?ctt?ttt?gcc?ctg?caa?cct?cat?ccg?ttg?aca?gtg?att?gat?caa 979

His?Pro?Leu?Phe?Ala?Leu?Gln?Pro?His?Pro?Leu?Thr?Val?Ile?Asp?Gln

280 285 290

aat?gta?gaa?caa?cta?gcc?caa?cga?gca?gtg?tct?atc?ctc?acc?gaa?tta 1027

Asn?Val?Glu?Gln?Leu?Ala?Gln?Arg?Ala?Val?Ser?Ile?Leu?Thr?Glu?Leu

295 300 305

att?gca?ggc?acg?gta?cct?agc?gtg?acg?aaa?act?acg?atc?ccc?act?gcc 1075

Ile?Ala?Gly?Thr?Val?Pro?Ser?Val?Thr?Lys?Thr?Thr?Ile?Pro?Thr?Ala

310 315 320 325

ctt?att?cat?cgt?gaa?tca?atc?atc?aac?tcc?act?tta?agg?aag?aag?gat 1123

Leu?Ile?His?Arg?Glu?Ser?Ile?Ile?Asn?Ser?Thr?Leu?Arg?Lys?Lys?Asp

330 335 340

gga?ctc?ccc?aat?gag?taactcaacc?ggtaccgaca?ttg 1161

Gly?Leu?Pro?Asn?Glu

345

<210>394

<211>346

<212>PRT

＜213〉Corynebacterium glutamicum

<400>394

Met?Ala?Thr?Glu?Lys?Phe?Arg?Pro?Thr?Leu?Lys?Asp?Val?Ala?Arg?Gln

1 5 10 15

Ala?Gly?Val?Ser?Ile?Ala?Thr?Ala?Ser?Arg?Ala?Leu?Ala?Asp?Asn?Pro

20 25 30

Ala?Val?Ala?Ala?Ser?Thr?Arg?Glu?Arg?Ile?Gln?Gln?Leu?Ala?Ser?Asp

35 40 45

Leu?Gly?Tyr?Arg?Ala?Asn?Ala?Gln?Ala?Arg?Ala?Leu?Arg?Ser?Ser?Arg

50 55 60

Ser?Asn?Thr?Ile?Gly?Val?Ile?Val?Pro?Ser?Leu?Ile?Asn?His?Tyr?Phe

65 70 75 80

Ala?Ala?Met?Val?Thr?Glu?Ile?Gln?Ser?Thr?Ala?Ser?Lys?Ala?Gly?Leu

85 90 95

Ala?Thr?Ile?Ile?Thr?Asn?Ser?Asn?Glu?Asp?Ala?Thr?Thr?Met?Ser?Gly

100 105 110

Ser?Leu?Glu?Phe?Leu?Thr?Ser?His?Gly?Val?Asp?Gly?Ile?Ile?Cys?Val

115 120 125

Pro?Asn?Glu?Glu?Cys?Ala?Asn?Gln?Leu?Glu?Asp?Leu?Gln?Lys?Gln?Gly

130 135 140

Met?Pro?Val?Val?Leu?Val?Asp?Arg?Glu?Leu?Pro?Gly?Asp?Ser?Thr?Ile

145 150 155 160

Pro?Thr?Ala?Thr?Ser?Asn?Pro?Gln?Pro?Gly?Ile?Ala?Ala?Ala?Val?Glu

165 170 175

Leu?Leu?Ala?His?Asn?Asn?Ala?Leu?Pro?Ile?Gly?Tyr?Leu?Ser?Gly?Pro

180 185 190

Met?Asp?Thr?Ser?Thr?Gly?Arg?Glu?Arg?Leu?Glu?Asp?Phe?Lys?Ala?Ala

195 200 205

Cys?Ala?Asn?Ser?Lys?Ile?Gly?Glu?Gln?Leu?Val?Phe?Leu?Gly?Gly?Tyr

210 215 220

Glu?Gln?Ser?Val?Gly?Phe?Glu?Gly?Ala?Thr?Lys?Leu?Leu?Asp?Gln?Gly

225 230 235 240

Ala?Lys?Thr?Leu?Phe?Ala?Gly?Asp?Ser?Met?Met?Thr?Ile?Gly?Val?Ile

245 250 255

Glu?Ala?Cys?His?Lys?Ala?Gly?Leu?Val?Ile?Gly?Lys?Asp?Val?Ser?Val

260 265 270

Ile?Gly?Phe?Asp?Thr?His?Pro?Leu?Phe?Ala?Leu?Gln?Pro?His?Pro?Leu

275 280 285

Thr?Val?Ile?Asp?Gln?Asn?Val?Glu?Gln?Leu?Ala?Gln?Arg?Ala?Val?Ser

290 295 300

Ile?Leu?Thr?Glu?Leu?Ile?Ala?Gly?Thr?Val?Pro?Ser?Val?Thr?Lys?Thr

305 310 315 320

Thr?Ile?Pro?Thr?Ala?Leu?Ile?His?Arg?Glu?Ser?Ile?Ile?Asn?Ser?Thr

325 330 335

Leu?Arg?Lys?Lys?Asp?Gly?Leu?Pro?Asn?Glu

340 345

<210>395

<211>483

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(460)

<223>RXA02551

<400>395

gctgcacaaa?ttccgcgaaa?gggtatcacc?atcgacatca?cagatgaaga?ccgtgagatc?60

ttaaaaaaac?accgtcgatt?tcatttcctt?ctcctattac?atg?tcc?gta?tgt?gaa 115

Met?Ser?Val?Cys?Glu

1 5

gcc?cac?aac?ccc?gaa?aac?tac?tca?acc?ggt?ggc?ggt?aac?atc?atc?ggc 163

Ala?His?Asn?Pro?Glu?Asn?Tyr?Ser?Thr?Gly?Gly?Gly?Asn?Ile?Ile?Gly

10 15 20

gga?gtg?gtc?agc?ccc?act?ctc?gcg?gct?tcc?gaa?tgg?ggt?tgg?caa?gtt 211

Gly?Val?Val?Ser?Pro?Thr?Leu?Ala?Ala?Ser?Glu?Trp?Gly?Trp?Gln?Val

25 30 35

gat?ccc?ctc?ggt?ttg?cgc?atc?gtc?ctg?aac?aac?tac?tgg?gag?cgc?tgg 259

Asp?Pro?Leu?Gly?Leu?Arg?Ile?Val?Leu?Asn?Asn?Tyr?Trp?Glu?Arg?Trp

40 45 50

cag?aag?cca?ctg?ttc?atc?gtc?gaa?aac?gga?cta?gga?gca?aag?gac?gtg 307

Gln?Lys?Pro?Leu?Phe?Ile?Val?Glu?Asn?Gly?Leu?Gly?Ala?Lys?Asp?Val

55 60 65

ctt?atc?gac?gga?ccc?tcc?ggc?cca?aca?gta?aac?gat?gac?tac?cgc?atc 355

Leu?Ile?Asp?Gly?Pro?Ser?Gly?Pro?Thr?Val?Asn?Asp?Asp?Tyr?Arg?Ile

70 75 80 85

aaa?tac?ctc?gac?gac?ggc?ggc?tca?gga?atc?ttg?aag?cgc?tac?aag?aag 403

Lys?Tyr?Leu?Asp?Asp?Gly?Gly?Ser?Gly?Ile?Leu?Lys?Arg?Tyr?Lys?Lys

90 95 100

aag?tcc?ttt?gat?tgg?tgc?cgc?gac?atc?atc?gcc?acc?aat?ggc?gaa?agc 451

Lys?Ser?Phe?Asp?Trp?Cys?Arg?Asp?Ile?Ile?Ala?Thr?Asn?Gly?Glu?Ser

105 110 115

ctg?gaa?tcc?taagaaataa?aggtaggtgt?cac 483

Leu?Glu?Ser

120

<210>396

<211>120

<212>PRT

＜213〉Corynebacterium glutamicum

<400>396

Met?Ser?Val?Cys?Glu?Ala?His?Asn?Pro?Glu?Asn?Tyr?Ser?Thr?Gly?Gly

1 5 10 15

Gly?Asn?Ile?Ile?Gly?Gly?Val?Val?Ser?Pro?Thr?Leu?Ala?Ala?Ser?Glu

20 25 30

Trp?Gly?Trp?Gln?Val?Asp?Pro?Leu?Gly?Leu?Arg?Ile?Val?Leu?Asn?Asn

35 40 45

Tyr?Trp?Glu?Arg?Trp?Gln?Lys?Pro?Leu?Phe?Ile?Val?Glu?Asn?Gly?Leu

50 55 60

Gly?Ala?Lys?Asp?Val?Leu?Ile?Asp?Gly?Pro?Ser?Gly?Pro?Thr?Val?Asn

65 70 75 80

Asp?Asp?Tyr?Arg?Ile?Lys?Tyr?Leu?Asp?Asp?Gly?Gly?Ser?Gly?Ile?Leu

85 90 95

Lys?Arg?Tyr?Lys?Lys?Lys?Ser?Phe?Asp?Trp?Cys?Arg?Asp?Ile?Ile?Ala

100 105 110

Thr?Asn?Gly?Glu?Ser?Leu?Glu?Ser

115 120

<210>397

<211>795

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(772)

<223>RXA01325

<400>397

gcgcagcgct?cggacgatta?cgaacttcag?gagaactcgg?ggtcattcgt?tgcattctac?60

cctggaaatt?ttcccacact?aagtcaggtc?taagtagggt?atg?gat?atg?acg?att 115

Met?Asp?Met?Thr?Ile

1 5

tcc?cgc?tcc?acc?atg?gcc?caa?atc?ctt?gac?tac?acc?ctc?ctc?gga?cca 163

Ser?Arg?Ser?Thr?Met?Ala?Gln?Ile?Leu?Asp?Tyr?Thr?Leu?Leu?Gly?Pro

10 15 20

gaa?gta?acc?aac?tcc?gaa?ctg?gcc?gca?ttt?ata?gat?tcc?gca?att?gag 211

Glu?Val?Thr?Asn?Ser?Glu?Leu?Ala?Ala?Phe?Ile?Asp?Ser?Ala?Ile?Glu

25 30 35

ctg?gga?gtc?ggc?acg?atc?tgt?gtc?ccc?aac?agc?atg?gtc?aac?cta?act 259

Leu?Gly?Val?Gly?Thr?Ile?Cys?Val?Pro?Asn?Ser?Met?Val?Asn?Leu?Thr

40 45 50

gca?aaa?gcc?caa?gaa?gct?gga?att?cga?gtg?gcc?acc?gtc?gca?gga?ttc 307

Ala?Lys?Ala?Gln?Glu?Ala?Gly?Ile?Arg?Val?Ala?Thr?Val?Ala?Gly?Phe

55 60 65

ccg?cac?ggc?aaa?acc?ccc?gcg?ttg?gtg?aaa?gcc?gcc?gaa?gcg?cgc?ctt 355

Pro?His?Gly?Lys?Thr?Pro?Ala?Leu?Val?Lys?Ala?Ala?Glu?Ala?Arg?Leu

70 75 80 85

gcc?gta?cag?tcc?gga?gct?tcc?gaa?gta?gat?gtt?gtt?ttg?gat?att?gcg 403

Ala?Val?Gln?Ser?Gly?Ala?Ser?Glu?Val?Asp?Val?Val?Leu?Asp?Ile?Ala

90 95 100

gta?gtg?aaa?gag?gga?gat?gcc?aat?agg?ttg?ctg?cag?gaa?att?gtg?gca 451

Val?Val?Lys?Glu?Gly?Asp?Ala?Asn?Arg?Leu?Leu?Gln?Glu?Ile?Val?Ala

105 110 115

atc?agg?gag?gct?gtt?cca?tct?cct?gtg?gtg?ctg?aaa?ttc?atc?ctc?gaa 499

Ile?Arg?Glu?Ala?Val?Pro?Ser?Pro?Val?Val?Leu?Lys?Phe?Ile?Leu?Glu

120 125 130

aca?gct?gtt?gtg?agt?gat?gaa?gca?att?gtg?act?gca?gtg?aat?gcg?ttg 547

Thr?Ala?Val?Val?Ser?Asp?Glu?Ala?Ile?Val?Thr?Ala?Val?Asn?Ala?Leu

135 140 145

att?gct?gct?ggt?gct?gac?ttc?gct?aaa?act?tcc?acg?gga?ttc?cac?cca 595

Ile?Ala?Ala?Gly?Ala?Asp?Phe?Ala?Lys?Thr?Ser?Thr?Gly?Phe?His?Pro

150 155 160 165

gcg?gga?ggg?gca?act?gtt?gag?gct?gtt?cgg?gtg?atg?gct?tcg?gct?tct 643

Ala?Gly?Gly?Ala?Thr?Val?Glu?Ala?Val?Arg?Val?Met?Ala?Ser?Ala?Ser

170 175 180

cgg?gga?agg?gtt?gga?att?aag?gct?gcc?ggt?ggg?gtg?aaa?act?tgg?gaa 691

Arg?Gly?Arg?Val?Gly?Ile?Lys?Ala?Ala?Gly?Gly?Val?Lys?Thr?Trp?Glu

185 190 195

gat?gcg?gtg?gcg?ttt?gtt?gaa?gca?ggg?gct?act?cgc?att?gga?act?tct 739

Asp?Ala?Val?Ala?Phe?Val?Glu?Ala?Gly?Ala?Thr?Arg?Ile?Gly?Thr?Ser

200 205 210

aat?gcg?gga?gcc?att?ttg?gag?ggt?gcg?ccg?gag?tagtttggcg?ttctaatcgg?792

Asn?Ala?Gly?Ala?Ile?Leu?Glu?Gly?Ala?Pro?Glu

215 220

gac 795

<210>398

<211>224

<212>PRT

＜213〉Corynebacterium glutamicum

<400>398

Met?Asp?Met?Thr?Ile?Ser?Arg?Ser?Thr?Met?Ala?Gln?Ile?Leu?Asp?Tyr

1 5 10 15

Thr?Leu?Leu?Gly?Pro?Glu?Val?Thr?Asn?Ser?Glu?Leu?Ala?Ala?Phe?Ile

20 25 30

Asp?Ser?Ala?Ile?Glu?Leu?Gly?Val?Gly?Thr?Ile?Cys?Val?Pro?Asn?Ser

35 40 45

Met?Val?Asn?Leu?Thr?Ala?Lys?Ala?Gln?Glu?Ala?Gly?Ile?Arg?Val?Ala

50 55 60

Thr?Val?Ala?Gly?Phe?Pro?His?Gly?Lys?Thr?Pro?Ala?Leu?Val?Lys?Ala

65 70 75 80

Ala?Glu?Ala?Arg?Leu?Ala?Val?Gln?Ser?Gly?Ala?Ser?Glu?Val?Asp?Val

85 90 95

Val?Leu?Asp?Ile?Ala?Val?Val?Lys?Glu?Gly?Asp?Ala?Asn?Arg?Leu?Leu

100 105 110

Gln?Glu?Ile?Val?Ala?Ile?Arg?Glu?Ala?Val?Pro?Ser?Pro?Val?Val?Leu

115 120 125

Lys?Phe?Ile?Leu?Glu?Thr?Ala?Val?Val?Ser?Asp?Glu?Ala?Ile?Val?Thr

130 135 140

Ala?Val?Asn?Ala?Leu?Ile?Ala?Ala?Gly?Ala?Asp?Phe?Ala?Lys?Thr?Ser

145 150 155 160

Thr?Gly?Phe?His?Pro?Ala?Gly?Gly?Ala?Thr?Val?Glu?Ala?Val?Arg?Val

165 170 175

Met?Ala?Ser?Ala?Ser?Arg?Gly?Arg?Val?Gly?Ile?Lys?Ala?Ala?Gly?Gly

180 185 190

Val?Lys?Thr?Trp?Glu?Asp?Ala?Val?Ala?Phe?Val?Glu?Ala?Gly?Ala?Thr

195 200 205

Arg?Ile?Gly?Thr?Ser?Asn?Ala?Gly?Ala?Ile?Leu?Glu?Gly?Ala?Pro?Glu

210 215 220

<210>399

<211>684

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(661)

<223>RXA00195

<400>399

tcgcagtcat?catgcaggca?taacctgaaa?cccatccgtt?tggattgccc?caaatgggtg?60

tagtgggtgc?gtttacccaa?caagtgcaag?aatgggagtc?gtg?act?aaa?aag?atc 115

Val?Thr?Lys?Lys?Ile

1 5

ctt?att?ttg?gga?agc?act?ggt?tcg?att?gga?act?cag?gcg?ctg?gac?gtt 163

Leu?Ile?Leu?Gly?Ser?Thr?Gly?Ser?Ile?Gly?Thr?Gln?Ala?Leu?Asp?Val

10 15 20

att?gct?gat?aat?tca?gac?aag?ttt?gag?gtg?gtg?ggt?atc?gct?gcg?ggc 211

Ile?Ala?Asp?Asn?Ser?Asp?Lys?Phe?Glu?Val?Val?Gly?Ile?Ala?Ala?Gly

25 30 35

ggt?tct?cag?cca?gac?ctc?gtt?att?tcg?cag?gcg?cag?cag?ttg?ggg?ctg 259

Gly?Ser?Gln?Pro?Asp?Leu?Val?Ile?Ser?Gln?Ala?Gln?Gln?Leu?Gly?Leu

40 45 50

gct?gca?gac?aag?gtt?gcg?gtt?gct?gat?gca?cag?gct?gcc?gca?gta?att 307

Ala?Ala?Asp?Lys?Val?Ala?Val?Ala?Asp?Ala?Gln?Ala?Ala?Ala?Val?Ile

55 60 65

tcg?aag?gct?ctc?ggc?ggc?gag?atc?atc?tct?gga?acc?gat?gct?gcg?aag 355

Ser?Lys?Ala?Leu?Gly?Gly?Glu?Ile?Ile?Ser?Gly?Thr?Asp?Ala?Ala?Lys

70 75 80 85

att?ctg?gtg?gaa?acc?aca?aag?gcc?gac?act?gtg?ctt?aat?gct?ctg?gtt 403

Ile?Leu?Val?Glu?Thr?Thr?Lys?Ala?Asp?Thr?Val?Leu?Asn?Ala?Leu?Val

90 95 100

ggt?tct?ttg?ggg?ctt?gcg?gca?acg?ctg?gcc?act?ctg?gaa?tct?ggt?gcg 451

Gly?Ser?Leu?Gly?Leu?Ala?Ala?Thr?Leu?Ala?Thr?Leu?Glu?Ser?Gly?Ala

105 110 115

cat?ctt?gcc?ttg?gct?aac?aaa?gaa?tcg?ctg?gtt?gcc?ggt?ggt?gag?ttt 499

His?Leu?Ala?Leu?Ala?Asn?Lys?Glu?Ser?Leu?Val?Ala?Gly?Gly?Glu?Phe

120 125 130

gtt?acc?tca?aag?gca?aag?ctg?ggg?cag?atc?att?ccg?gtc?gat?tcg?gag 547

Val?Thr?Ser?Lys?Ala?Lys?Leu?Gly?Gln?Ile?Ile?Pro?Val?Asp?Ser?Glu

135 140 145

cac?tct?gcc?atg?gcg?cag?tgt?ttg?cgt?tcg?ggt?act?cgt?gat?gag?gtt 595

His?Ser?Ala?Met?Ala?Gln?Cys?Leu?Arg?Ser?Gly?Thr?Arg?Asp?Glu?Val

150 155 160 165

gcg?cgg?att?gtg?ctg?aca?gct?tcg?ggc?gga?cct?ttc?agg?gct?gga?cca 643

Ala?Ara?Ile?Val?Leu?Thr?Ala?Ser?Gly?Gly?Pro?Phe?Arg?Ala?Gly?Pro

170 175 180

ggg?aga?aga?tgt?ggg?agg?tgactcccga?gcaggcagca?gcg 684

Gly?Arg?Arg?Cys?Gly?Arg

185

<210>400

<211>187

<212>PRT

＜213〉Corynebacterium glutamicum

<400>400

Val?Thr?Lys?Lys?Ile?Leu?Ile?Leu?Gly?Ser?Thr?Gly?Ser?Ile?Gly?Thr

1 5 10 15

Gln?Ala?Leu?Asp?Val?Ile?Ala?Asp?Asn?Ser?Asp?Lys?Phe?Glu?Val?Val

20 25 30

Gly?Ile?Ala?Ala?Gly?Gly?Ser?Gln?Pro?Asp?Leu?Val?Ile?Ser?Gln?Ala

35 40 45

Gln?Gln?Leu?Gly?Leu?Ala?Ala?Asp?Lys?Val?Ala?Val?Ala?Asp?Ala?Gln

50 55 60

Ala?Ala?Ala?Val?Ile?Ser?Lys?Ala?Leu?Gly?Gly?Glu?Ile?Ile?Ser?Gly

65 70 75 80

Thr?Asp?Ala?Ala?Lys?Ile?Leu?Val?Glu?Thr?Thr?Lys?Ala?Asp?Thr?Val

85 90 95

Leu?Asn?Ala?Leu?Val?Gly?Ser?Leu?Gly?Leu?Ala?Ala?Thr?Leu?Ala?Thr

100 105 110

Leu?Glu?Ser?Gly?Ala?His?Leu?Ala?Leu?Ala?Asn?Lys?Glu?Ser?Leu?Val

115 120 125

Ala?Gly?Gly?Glu?Phe?Val?Thr?Ser?Lys?Ala?Lys?Leu?Gly?Gln?Ile?Ile

130 135 140

Pro?Val?Asp?Ser?Glu?His?Ser?Ala?Met?Ala?Gln?Cys?Leu?Arg?Ser?Gly

145 150 155 160

Thr?Arg?Asp?Glu?Val?Ala?Arg?Ile?Val?Leu?Thr?Ala?Ser?Gly?Gly?Pro

165 170 175

Phe?Arg?Ala?Gly?Pro?Gly?Arg?Arg?Cys?Gly?Arg

180 185

<210>401

<211>738

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(715)

<223>RXA00196

<400>401

ctgccatggc?gcagtgtttg?cgttcgggta?ctcgtgatga?ggttgcgcgg?attgtgctga?60

cagcttcggg?cggacctttc?agggctggac?cagggagaag?atg?tgg?gag?gtg?act 115

Met?Trp?Glu?Val?Thr

1 5

ccc?gag?cag?gca?gca?gcg?cac?cca?acg?tgg?gcg?atg?ggg?cag?atg?aac 163

Pro?Glu?Gln?Ala?Ala?Ala?His?Pro?Thr?Trp?Ala?Met?Gly?Gln?Met?Asn

10 15 20

acg?ttg?aac?tcc?gcc?acc?ctt?att?aat?aaa?ggc?ctc?gaa?ctc?atc?gag 211

Thr?Leu?Asn?Ser?Ala?Thr?Leu?Ile?Asn?Lys?Gly?Leu?Glu?Leu?Ile?Glu

25 30 35

gcg?acc?ctg?ctg?ttt?gaa?acg?gat?gcg?gat?ctc?att?gat?gtg?acg?gtg 259

Ala?Thr?Leu?Leu?Phe?Glu?Thr?Asp?Ala?Asp?Leu?Ile?Asp?Val?Thr?Val

40 45 50

cat?ccg?cag?tcg?atc?atc?cac?tcc?atg?atc?acg?ttt?acg?gat?ggt?gcg 307

His?Pro?Gln?Ser?Ile?Ile?His?Ser?Met?Ile?Thr?Phe?Thr?Asp?Gly?Ala

55 60 65

acc?atc?gcg?cag?gcg?tcg?cca?cca?tcg?atg?aaa?ctg?ccg?atc?gcg?ttg 355

Thr?Ile?Ala?Gln?Ala?Ser?Pro?Pro?Ser?Met?Lys?Leu?Pro?Ile?Ala?Leu

70 75 80 85

gcg?ctt?gat?tgg?cca?cat?cgg?gtg?ccg?aag?gct?cag?ccg?gcg?ctg?gat 403

Ala?Leu?Asp?Trp?Pro?His?Arg?Val?Pro?Lys?Ala?Gln?Pro?Ala?Leu?Asp

90 95 100

ttc?acc?gct?gct?cat?acc?tgg?gct?ttt?gag?ccg?gtg?gat?gat?gcc?gca 451

Phe?Thr?Ala?Ala?His?Thr?Trp?Ala?Phe?Glu?Pro?Val?Asp?Asp?Ala?Ala

105 110 115

ttc?cct?gcg?gtg?cag?ctg?gct?agg?cac?gtc?gca?aag?caa?aaa?ggc?acg 499

Phe?Pro?Ala?Val?Gln?Leu?Ala?Arg?His?Val?Ala?Lys?Gln?Lys?Gly?Thr

120 125 130

tac?ccc?gcg?gtg?tat?aac?gcc?gcc?aac?gag?gag?gcg?gct?gag?gcg?ttt 547

Tyr?Pro?Ala?Val?Tyr?Asn?Ala?Ala?Asn?Glu?Glu?Ala?Ala?Glu?Ala?Phe

135 140 145

ttg?cgc?ggg?cga?atc?aag?ttt?ccg?cag?atc?gtg?gac?gtg?gtg?gac?gag 595

Leu?Arg?Gly?Arg?Ile?Lys?Phe?Pro?Gln?Ile?Val?Asp?Val?Val?Asp?Glu

150 155 160 165

gtc?ctc?caa?gga?gct?tct?cag?ttt?gct?ggt?gta?gca?tca?cac?gtc?gat 643

Val?Leu?Gln?Gly?Ala?Ser?Gln?Phe?Ala?Gly?Val?Ala?Ser?His?Val?Asp

170 175 180

gat?att?ttg?gca?acc?gaa?tct?gag?gca?cgc?gcg?cgt?gcg?aat?gct?ttg 691

Asp?Ile?Leu?Ala?Thr?Glu?Ser?Glu?Ala?Arg?Ala?Arg?Ala?Asn?Ala?Leu

185 190 195

atc?aac?cgg?ttg?gca?acc?aac?ttg?taagctaagg?agcttccgcc?tcg 738

Ile?Asn?Arg?Leu?Ala?Thr?Asn?Leu

200 205

<210>402

<211>205

<212>PRT

＜213〉Corynebacterium glutamicum

<400>402

Met?Trp?Glu?Val?Thr?Pro?Glu?Gln?Ala?Ala?Ala?His?Pro?Thr?Trp?Ala

1 5 10 15

Met?Gly?Gln?Met?Asn?Thr?Leu?Asn?Ser?Ala?Thr?Leu?Ile?Asn?Lys?Gly

20 25 30

Leu?Glu?Leu?Ile?Glu?Ala?Thr?Leu?Leu?Phe?Glu?Thr?Asp?Ala?Asp?Leu

35 40 45

Ile?Asp?Val?Thr?Val?His?Pro?Gln?Ser?Ile?Ile?His?Ser?Met?Ile?Thr

50 55 60

Phe?Thr?Asp?Gly?Ala?Thr?Ile?Ala?Gln?Ala?Ser?Pro?Pro?Ser?Met?Lys

65 70 75 80

Leu?Pro?Ile?Ala?Leu?Ala?Leu?Asp?Trp?Pro?His?Arg?Val?Pro?Lys?Ala

85 90 95

Gln?Pro?Ala?Leu?Asp?Phe?Thr?Ala?Ala?His?Thr?Trp?Ala?Phe?Glu?Pro

100 105 110

Val?Asp?Asp?Ala?Ala?Phe?Pro?Ala?Val?Gln?Leu?Ala?Arg?His?Val?Ala

115 120 125

Lys?Gln?Lys?Gly?Thr?Tyr?Pro?Ala?Val?Tyr?Asn?Ala?Ala?Asn?Glu?Glu

130 135 140

Ala?Ala?Glu?Ala?Phe?Leu?Arg?Gly?Arg?Ile?Lys?Phe?Pro?Gln?Ile?Val

145 150 155 160

Asp?Val?Val?Asp?Glu?Val?Leu?Gln?Gly?Ala?Ser?Gln?Phe?Ala?Gly?Val

165 170 175

Ala?Ser?His?Val?Asp?Asp?Ile?Leu?Ala?Thr?Glu?Ser?Glu?Ala?Arg?Ala

180 185 190

Arg?Ala?Asn?Ala?Leu?Ile?Asn?Arg?Leu?Ala?Thr?Asn?Leu

195 200 205

<210>403

<211>2031

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(2008)

<223>RXN01562

<400>403

gcaggtgcac?atttgttttg?tcacctgcac?aaaagtgtcg?ccagcccgat?acttgtacaa?60

ccgtccgcat?ccgagaagca?aaggtgtctg?actcgcgcca?atg?gga?att?ctg?aac 115

Met?Gly?Ile?Leu?Asn

1 5

agt?att?tca?aca?cct?gct?gac?tta?aag?gcc?ctt?aat?gat?gag?gat?ttg 163

Ser?Ile?Ser?Thr?Pro?Ala?Asp?Leu?Lys?Ala?Leu?Asn?Asp?Glu?Asp?Leu

10 15 20

gac?gct?ctt?gcc?aaa?gaa?atc?cga?act?ttc?ctg?gtc?gat?aaa?gtc?gca 211

Asp?Ala?Leu?Ala?Lys?Glu?Ile?Arg?Thr?Phe?Leu?Val?Asp?Lys?Val?Ala

25 30 35

gca?act?ggt?ggc?cac?tta?ggt?cca?aat?ttg?ggc?gta?gtg?gaa?tta?acc 259

Ala?Thr?Gly?Gly?His?Leu?Gly?Pro?Asn?Leu?Gly?Val?Val?Glu?Leu?Thr

40 45 50

atc?ggt?ctt?cat?cga?gtt?ttc?gat?tcg?cct?caa?gac?ccg?atc?atc?ttt 307

Ile?Gly?Leu?His?Arg?Val?Phe?Asp?Ser?Pro?Gln?Asp?Pro?Ile?Ile?Phe

55 60 65

gat?act?tct?cac?cag?tcc?tat?gtg?cat?aag?atc?ctg?acg?ggt?cgc?gct 355

Asp?Thr?Ser?His?Gln?Ser?Tyr?Val?His?Lys?Ile?Leu?Thr?Gly?Arg?Ala

70 75 80 85

aaa?gat?ttt?gat?tct?ttg?cgt?caa?aaa?gat?ggc?ctt?tct?ggt?tac?acc 403

Lys?Asp?Phe?Asp?Ser?Leu?Arg?Gln?Lys?Asp?Gly?Leu?Ser?Gly?Tyr?Thr

90 95 100

tgc?cgt?gct?gaa?agt?gag?cac?gat?tgg?act?gag?tct?tcg?cat?gct?tcg 451

Cys?Arg?Ala?Glu?Ser?Glu?His?Asp?Trp?Thr?Glu?Ser?Ser?His?Ala?Ser

105 110 115

gcg?gcc?ttg?tct?tat?gcg?gat?ggt?ttg?tct?aaa?gcc?aag?cag?ttg?gat 499

Ala?Ala?Leu?Ser?Tyr?Ala?Asp?Gly?Leu?Ser?Lys?Ala?Lys?Gln?Leu?Asp

120 125 130

ggc?gat?acc?acg?cat?agt?gtg?gtt?gct?gtc?gtt?ggt?gat?ggc?gct?cta 547

Gly?Asp?Thr?Thr?His?Ser?Val?Val?Ala?Val?Val?Gly?Asp?Gly?Ala?Leu

135 140 145

act?ggc?ggc?atg?tgt?tgg?gaa?gca?ctg?aac?aat?att?gct?gct?ggt?aaa 595

Thr?Gly?Gly?Met?Cys?Trp?Glu?Ala?Leu?Asn?Asn?Ile?Ala?Ala?Gly?Lys

150 155 160 165

gac?cgc?aaa?gtt?gtt?gtc?gta?gtc?aat?gac?aat?ggc?cgg?agt?tat?tct 643

Asp?Arg?Lys?Val?Val?Val?Val?Val?Asn?Asp?Asn?Gly?Arg?Ser?Tyr?Ser

170 175 180

cca?acc?att?ggc?gga?ttt?gcg?gaa?aac?ctt?gcg?ggc?ctt?cgc?atg?cag 691

Pro?Thr?Ile?Gly?Gly?Phe?Ala?Glu?Asn?Leu?Ala?Gly?Leu?Arg?Met?Gln

185 190 195

cct?ttc?tat?gat?cgc?ttc?atg?gaa?aag?ggc?aag?acg?tcc?ctg?aaa?tcc 739

Pro?Phe?Tyr?Asp?Arg?Phe?Met?Glu?Lys?Gly?Lys?Thr?Ser?Leu?Lys?Ser

200 205 210

atg?ggg?tgg?gta?ggg?gag?cgt?act?ttt?gaa?gcg?ctc?cat?gca?ttt?aaa 787

Met?Gly?Trp?Val?Gly?Glu?Arg?Thr?Phe?Glu?Ala?Leu?His?Ala?Phe?Lys

215 220 225

gaa?ggt?gtg?aag?agc?acc?gtc?att?ccc?acc?gaa?atg?ttc?cct?gaa?ctg 835

Glu?Gly?Val?Lys?Ser?Thr?Val?Ile?Pro?Thr?Glu?Met?Phe?Pro?Glu?Leu

230 235 240 245

ggc?atg?aaa?tac?gtg?ggt?ccg?gtt?gat?gga?cat?aac?caa?aaa?gct?gtc 883

Gly?Met?Lys?Tyr?Val?Gly?Pro?Val?Asp?Gly?His?Asn?Gln?Lys?Ala?Val

250 255 260

gac?aat?gcg?ctg?aaa?tac?gct?cat?gat?tat?gat?ggc?ccc?atc?atc?gtg 931

Asp?Asn?Ala?Leu?Lys?Tyr?Ala?His?Asp?Tyr?Asp?Gly?Pro?Ile?Ile?Val

265 270 275

cac?atg?gtc?acc?gaa?aag?ggt?cgt?ggt?tac?gcg?cct?gct?gag?cag?gat 979

His?Met?Val?Thr?Glu?Lys?Gly?Arg?Gly?Tyr?Ala?Pro?Ala?Glu?Gln?Asp

280 285 290

ttg?gac?gaa?ttg?atg?cac?tcc?acg?ggc?gtc?atc?gat?ccg?ctc?aca?gga 1027

Leu?Asp?Glu?Leu?Met?His?Ser?Thr?Gly?Val?Ile?Asp?Pro?Leu?Thr?Gly

295 300 305

gct?cct?aaa?tct?gca?tca?aag?ccc?ggt?tgg?acc?tct?gtg?ttc?agc?gat 1075

Ala?Pro?Lys?Ser?Ala?Ser?Lys?Pro?Gly?Trp?Thr?Ser?Val?Phe?Ser?Asp

310 315 320 325

gag?ctg?gtc?aag?att?ggt?gcg?cag?aat?gaa?aac?gtt?gtt?gcc?atc?acc 1123

Glu?Leu?Val?Lys?Ile?Gly?Ala?Gln?Asn?Glu?Asn?Val?Val?Ala?Ile?Thr

330 335 340

gcc?gcg?atg?gca?ggt?cct?acc?ggt?ctg?tcc?aag?ttc?gaa?gcc?aat?ttc 1171

Ala?Ala?Met?Ala?Gly?Pro?Thr?Gly?Leu?Ser?Lys?Phe?Glu?Ala?Asn?Phe

345 350 355

ccc?aac?cga?ttc?ttt?gat?gtc?ggc?att?gct?gag?cag?cac?gcg?gta?act 1219

Pro?Asn?Arg?Phe?Phe?Asp?Val?Gly?Ile?Ala?Glu?Gln?His?Ala?Val?Thr

360 365 370

tct?gcc?gca?ggc?ctc?gca?ttg?ggt?gga?aaa?cac?cct?gtg?gtg?gct?att 1267

Ser?Ala?Ala?Gly?Leu?Ala?Leu?Gly?Gly?Lys?His?Pro?Val?Val?Ala?Ile

375 380 385

tac?tcc?acg?ttc?ttg?aac?cgc?gct?ttt?gat?cag?ctg?ctc?atg?gat?gtg 1315

Tyr?Ser?Thr?Phe?Leu?Asn?Arg?Ala?Phe?Asp?Gln?Leu?Leu?Met?Asp?Val

390 395 400 405

ggc?atg?ctc?aac?cag?cct?gtt?act?ttg?gtg?ctt?gat?cgc?tca?ggt?gtc 1363

Gly?Met?Leu?Asn?Gln?Pro?Val?Thr?Leu?Val?Leu?Asp?Arg?Ser?Gly?Val

410 415 420

acg?ggt?tcg?gat?gga?gcg?agc?cac?aat?ggc?gtc?tgg?gat?atg?gcg?ctg 1411

Thr?Gly?Ser?Asp?Gly?Ala?Ser?His?Asn?Gly?Val?Trp?Asp?Met?Ala?Leu

425 430 435

acc?tcg?atc?gtt?cca?ggc?gtg?cag?gtg?gcg?gca?cca?cgt?gat?gag?gat 1459

Thr?Ser?Ile?Val?Pro?Gly?Val?Gln?Val?Ala?Ala?Pro?Arg?Asp?Glu?Asp

440 445 450

tcc?ttg?cgt?gag?ctg?ctc?aat?gag?gct?att?tcc?atc?gat?gat?ggc?ccc 1507

Ser?Leu?Arg?Glu?Leu?Leu?Asn?Glu?Ala?Ile?Ser?Ile?Asp?Asp?Gly?Pro

455 460 465

aca?gtt?gtg?cgt?ttc?ccc?aag?ggc?gac?ttg?cca?act?cca?att?gtt?gct 1555

Thr?Val?Val?Arg?Phe?Pro?Lys?Gly?Asp?Leu?Pro?Thr?Pro?Ile?Val?Ala

470 475 480 485

atc?gac?acc?ttg?gaa?gac?ggc?gtg?gat?gtc?ctc?gca?tat?gaa?gac?gcc 1603

Ile?Asp?Thr?Leu?Glu?Asp?Gly?Val?Asp?Val?Leu?Ala?Tyr?Glu?Asp?Ala

490 495 500

act?gac?gtt?gaa?tca?acc?gac?gat?gcg?cca?tca?gtt?ctc?atc?att?gcg 1651

Thr?Asp?Val?Glu?Ser?Thr?Asp?Asp?Ala?Pro?Ser?Val?Leu?Ile?Ile?Ala

505 510 515

gta?ggc?gag?cgc?gca?act?gtt?gca?ctt?gac?gtt?gct?tcc?agg?att?aaa 1699

Val?Gly?Glu?Arg?Ala?Thr?Val?Ala?Leu?Asp?Val?Ala?Ser?Arg?Ile?Lys

520 525 530

cag?cac?ggc?gtg?aac?gtc?acg?gtt?gtt?gac?ccc?cgc?tgg?att?gtc?ccc 1747

Gln?His?Gly?Val?Asn?Val?Thr?Val?Val?Asp?Pro?Arg?Trp?Ile?Val?Pro

535 540 545

atc?ccg?cag?tcc?ttg?gtc?gcg?ctg?tct?gat?gat?cat?gac?ctc?gtg?atc 1795

Ile?Pro?Gln?Ser?Leu?Val?Ala?Leu?Ser?Asp?Asp?His?Asp?Leu?Val?Ile

550 555 560 565

acc?atc?gaa?gac?ggc?gtc?atc?cac?ggc?ggc?gtg?gga?tcc?ttg?ctc?tct 1843

Thr?Ile?Glu?Asp?Gly?Val?Ile?His?Gly?Gly?Val?Gly?Ser?Leu?Leu?Ser

570 575 580

gat?gcg?ctt?aac?gcc?tct?gag?gtg?gat?acc?cct?cgc?cga?caa?atc?gcc 1891

Asp?Ala?Leu?Asn?Ala?Ser?Glu?Val?Asp?Thr?Pro?Arg?Arg?Gln?Ile?Ala

585 590 595

gtg?ccc?cag?aag?tac?ctg?gat?cac?gcg?tcc?cgc?aat?gaa?gtg?ctc?gcc 1939

Val?Pro?Gln?Lys?Tyr?Leu?Asp?His?Ala?Ser?Arg?Asn?Glu?Val?Leu?Ala

600 605 610

gat?tat?ggc?ctc?gac?gcc?gac?ggc?att?gaa?acc?act?gtt?gtt?gga?tgg 1987

Asp?Tyr?Gly?Leu?Asp?Ala?Asp?Gly?Ile?Glu?Thr?Thr?Val?Val?Gly?Trp

615 620 625

ctg?gat?tcc?ctg?ttc?ggg?gaa?taaaaccctg?cttatcgacg?ccg 2031

Leu?Asp?Ser?Leu?Phe?Gly?Glu

630 635

<210>404

<211>636

<212>PRT

＜213〉Corynebacterium glutamicum

<400>404

Met?Gly?Ile?Leu?Asn?Ser?Ile?Ser?Thr?Pro?Ala?Asp?Leu?Lys?Ala?Leu

1 5 10 15

Asn?Asp?Glu?Asp?Leu?Asp?Ala?Leu?Ala?Lys?Glu?Ile?Arg?Thr?Phe?Leu

20 25 30

Val?Asp?Lys?Val?Ala?Ala?Thr?Gly?Gly?His?Leu?Gly?Pro?Asn?Leu?Gly

35 40 45

Val?Val?Glu?Leu?Thr?Ile?Gly?Leu?His?Arg?Val?Phe?Asp?Ser?Pro?Gln

50 55 60

Asp?Pro?Ile?Ile?Phe?Asp?Thr?Ser?His?Gln?Ser?Tyr?Val?His?Lys?Ile

65 70 75 80

Leu?Thr?Gly?Arg?Ala?Lys?Asp?Phe?Asp?Ser?Leu?Arg?Gln?Lys?Asp?Gly

85 90 95

Leu?Ser?Gly?Tyr?Thr?Cys?Arg?Ala?Glu?Ser?Glu?His?Asp?Trp?Thr?Glu

100 105 110

Ser?Ser?His?Ala?Ser?Ala?Ala?Leu?Ser?Tyr?Ala?Asp?Gly?Leu?Ser?Lys

115 120 125

Ala?Lys?Gln?Leu?Asp?Gly?Asp?Thr?Thr?His?Ser?Val?Val?Ala?Val?Val

130 135 140

Gly?Asp?Gly?Ala?Leu?Thr?Gly?Gly?Met?Cys?Trp?Glu?Ala?Leu?Asn?Asn

145 150 155 160

Ile?Ala?Ala?Gly?Lys?Asp?Arg?Lys?Val?Val?Val?Val?Val?Asn?Asp?Asn

165 170 175

Gly?Arg?Ser?Tyr?Ser?Pro?Thr?Ile?Gly?Gly?Phe?Ala?Glu?Asn?Leu?Ala

180 185 190

Gly?Leu?Arg?Met?Gln?Pro?Phe?Tyr?Asp?Arg?Phe?Met?Glu?Lys?Gly?Lys

195 200 205

Thr?Ser?Leu?Lys?Ser?Met?Gly?Trp?Val?Gly?Glu?Arg?Thr?Phe?Glu?Ala

210 215 220

Leu?His?Ala?Phe?Lys?Glu?Gly?Val?Lys?Ser?Thr?Val?Ile?Pro?Thr?Glu

225 230 235 240

Met?Phe?Pro?Glu?Leu?Gly?Met?Lys?Tyr?Val?Gly?Pro?Val?Asp?Gly?His

245 250 255

Asn?Gln?Lys?Ala?Val?Asp?Asn?Ala?Leu?Lys?Tyr?Ala?His?Asp?Tyr?Asp

260 265 270

Gly?Pro?Ile?Ile?Val?His?Met?Val?Thr?Glu?Lys?Gly?Arg?Gly?Tyr?Ala

275 280 285

Pro?Ala?Glu?Gln?Asp?Leu?Asp?Glu?Leu?Met?His?Ser?Thr?Gly?Val?Ile

290 295 300

Asp?Pro?Leu?Thr?Gly?Ala?Pro?Lys?Ser?Ala?Ser?Lys?Pro?Gly?Trp?Thr

305 310 315 320

Ser?Val?Phe?Ser?Asp?Glu?Leu?Val?Lys?Ile?Gly?Ala?Gln?Asn?Glu?Asn

325 330 335

Val?Val?Ala?Ile?Thr?Ala?Ala?Met?Ala?Gly?Pro?Thr?Gly?Leu?Ser?Lys

340 345 350

Phe?Glu?Ala?Asn?Phe?Pro?Asn?Arg?Phe?Phe?Asp?Val?Gly?Ile?Ala?Glu

355 360 365

Gln?His?Ala?Val?Thr?Ser?Ala?Ala?Gly?Leu?Ala?Leu?Gly?Gly?Lys?His

370 375 380

Pro?Val?Val?Ala?Ile?Tyr?Ser?Thr?Phe?Leu?Asn?Arg?Ala?Phe?Asp?Gln

385 390 395 400

Leu?Leu?Met?Asp?Val?Gly?Met?Leu?Asn?Gln?Pro?Val?Thr?Leu?Val?Leu

405 410 415

Asp?Arg?Ser?Gly?Val?Thr?Gly?Ser?Asp?Gly?Ala?Ser?His?Asn?Gly?Val

420 425 430

Trp?Asp?Met?Ala?Leu?Thr?Ser?Ile?Val?Pro?Gly?Val?Gln?Val?Ala?Ala

435 440 445

Pro?Arg?Asp?Glu?Asp?Ser?Leu?Arg?Glu?Leu?Leu?Asn?Glu?Ala?Ile?Ser

450 455 460

Ile?Asp?Asp?Gly?Pro?Thr?Val?Val?Arg?Phe?Pro?Lys?Gly?Asp?Leu?Pro

465 470 475 480

Thr?Pro?Ile?Val?Ala?Ile?Asp?Thr?Leu?Glu?Asp?Gly?Val?Asp?Val?Leu

485 490 495

Ala?Tyr?Glu?Asp?Ala?Thr?Asp?Val?Glu?Ser?Thr?Asp?Asp?Ala?Pro?Ser

500 505 510

Val?Leu?Ile?Ile?Ala?Val?Gly?Glu?Arg?Ala?Thr?Val?Ala?Leu?Asp?Val

515 520 525

Ala?Ser?Arg?Ile?Lys?Gln?His?Gly?Val?Asn?Val?Thr?Val?Val?Asp?Pro

530 535 540

Arg?Trp?Ile?Val?Pro?Ile?Pro?Gln?Ser?Leu?Val?Ala?Leu?Ser?Asp?Asp

545 550 555 560

His?Asp?Leu?Val?Ile?Thr?Ile?Glu?Asp?Gly?Val?Ile?His?Gly?Gly?Val

565 570 575

Gly?Ser?Leu?Leu?Ser?Asp?Ala?Leu?Asn?Ala?Ser?Glu?Val?Asp?Thr?Pro

580 585 590

Arg?Arg?Gln?Ile?Ala?Val?Pro?Gln?Lys?Tyr?Leu?Asp?His?Ala?Ser?Arg

595 600 605

Asn?Glu?Val?Leu?Ala?Asp?Tyr?Gly?Leu?Asp?Ala?Asp?Gly?Ile?Glu?Thr

610 615 620

Thr?Val?Val?Gly?Trp?Leu?Asp?Ser?Leu?Phe?Gly?Glu

625 630 635

<210>405

<211>1061

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(1038)

<223>FRXA01562

<400>405

gag?cag?gat?ttg?gac?gaa?ttg?atg?cac?tcc?acg?ggc?gtc?atc?gat?ccg 48

Glu?Gln?Asp?Leu?Asp?Glu?Leu?Met?His?Ser?Thr?Gly?Val?Ile?Asp?Pro

1 5 10 15

ctc?aca?gga?gct?cct?aaa?tct?gca?tca?aag?ccc?ggt?tgg?acc?tct?gtg 96

Leu?Thr?Gly?Ala?Pro?Lys?Ser?Ala?Ser?Lys?Pro?Gly?Trp?Thr?Ser?Val

20 25 30

ttc?agc?gat?gag?ctg?gtc?aag?att?ggt?gcg?cag?aat?gaa?aac?gtt?gtt 144

Phe?Ser?Asp?Glu?Leu?Val?Lys?Ile?Gly?Ala?Gln?Asn?Glu?Asn?Val?Val

35 40 45

gcc?atc?acc?gcc?gcg?atg?gca?ggt?cct?acc?ggt?ctg?tcc?aag?ttc?gaa 192

Ala?Ile?Thr?Ala?Ala?Met?Ala?Gly?Pro?Thr?Gly?Leu?Ser?Lys?Phe?Glu

50 55 60

gcc?aat?ttc?ccc?aac?cga?ttc?ttt?gat?gtc?ggc?att?gct?gag?cag?cac 240

Ala?Asn?Phe?Pro?Asn?Arg?Phe?Phe?Asp?Val?Gly?Ile?Ala?Glu?Gln?His

65 70 75 80

gcg?gta?act?tct?gcc?gca?ggc?ctc?gca?ttg?ggt?gga?aaa?cac?cct?gtg 288

Ala?Val?Thr?Ser?Ala?Ala?Gly?Leu?Ala?Leu?Gly?Gly?Lys?His?Pro?Val

85 90 95

gtg?gct?att?tac?tcc?acg?ttc?ttg?aac?cgc?gct?ttt?gat?cag?ctg?ctc 336

Val?Ala?Ile?Tyr?Ser?Thr?Phe?Leu?Asn?Arg?Ala?Phe?Asp?Gln?Leu?Leu

100 105 110

atg?gat?gtg?ggc?atg?ctc?aac?cag?cct?gtt?act?ttg?gtg?ctt?gat?cgc 384

Met?Asp?Val?Gly?Met?Leu?Asn?Gln?Pro?Val?Thr?Leu?Val?Leu?Asp?Arg

115 120 125

tca?ggt?gtc?acg?ggt?tcg?gat?gga?gcg?agc?cac?aat?ggc?gtc?tgg?gat 432

Ser?Gly?Val?Thr?Gly?Ser?Asp?Gly?Ala?Ser?His?Asn?Gly?Val?Trp?Asp

130 135 140

atg?gcg?ctg?acc?tcg?atc?gtt?cca?ggc?gtg?cag?gtg?gcg?gca?cca?cgt 480

Met?Ala?Leu?Thr?Ser?Ile?Val?Pro?Gly?Val?Gln?Val?Ala?Ala?Pro?Arg

145 150 155 160

gat?gag?gat?tcc?ttg?cgt?gag?ctg?ctc?aat?gag?gct?att?tcc?atc?gat 528

Asp?Glu?Asp?Ser?Leu?Arg?Glu?Leu?Leu?Asn?Glu?Ala?Ile?Ser?Ile?Asp

165 170 175

gat?ggc?ccc?aca?gtt?gtg?cgt?ttc?ccc?aag?ggc?gac?ttg?cca?act?cca 576

Asp?Gly?Pro?Thr?Val?Val?Arg?Phe?Pro?Lys?Gly?Asp?Leu?Pro?Thr?Pro

180 185 190

att?gtt?gct?atc?gac?acc?ttg?gaa?gac?ggc?gtg?gat?gtc?ctc?gca?tat 624

Ile?Val?Ala?Ile?Asp?Thr?Leu?Glu?Asp?Gly?Val?Asp?Val?Leu?Ala?Tyr

195 200 205

gaa?gac?gcc?act?gac?gtt?gaa?tca?acc?gac?gat?gcg?cca?tca?gtt?ctc 672

Glu?Asp?Ala?Thr?Asp?Val?Glu?Ser?Thr?Asp?Asp?Ala?Pro?Ser?Val?Leu

210 215 220

atc?att?gcg?gta?ggc?gag?cgc?gca?act?gtt?gca?ctt?gac?gtt?gct?tcc 720

Ile?Ile?Ala?Val?Gly?Glu?Arg?Ala?Thr?Val?Ala?Leu?Asp?Val?Ala?Ser

225 230 235 240

agg?att?aaa?cag?cac?ggc?gtg?aac?gtc?acg?gtt?gtt?gac?ccc?cgc?tgg 768

Arg?Ile?Lys?Gln?His?Gly?Val?Asn?Val?Thr?Val?Val?Asp?Pro?Arg?Trp

245 250 255

att?gtc?ccc?atc?ccg?cag?tcc?ttg?gtc?gcg?ctg?tct?gat?gat?cat?gac 816

Ile?Val?Pro?Ile?Pro?Gln?Ser?Leu?Val?Ala?Leu?Ser?Asp?Asp?His?Asp

260 265 270

ctc?gtg?atc?acc?atc?gaa?gac?ggc?gtc?atc?cac?ggc?ggc?gtg?gga?tcc 864

Leu?Val?Ile?Thr?Ile?Glu?Asp?Gly?Val?Ile?His?Gly?Gly?Val?Gly?Ser

275 280 285

ttg?ctc?tct?gat?gcg?ctt?aac?gcc?tct?gag?gtg?gat?acc?cct?cgc?cga 912

Leu?Leu?Ser?Asp?Ala?Leu?Asn?Ala?Ser?Glu?Val?Asp?Thr?Pro?Arg?Arg

290 295 300

caa?atc?gcc?gtg?ccc?cag?aag?tac?ctg?gat?cac?gcg?tcc?cgc?aat?gaa 960

Gln?Ile?Ala?Val?Pro?Gln?Lys?Tyr?Leu?Asp?His?Ala?Ser?Arg?Asn?Glu

305 310 315 320

gtg?ctc?gcc?gat?tat?ggc?ctc?gac?gcc?gac?ggc?att?gaa?acc?act?gtt 1008

Val?Leu?Ala?Asp?Tyr?Gly?Leu?Asp?Ala?Asp?Gly?Ile?Glu?Thr?Thr?Val

325 330 335

gtt?gga?tgg?ctg?gat?tcc?ctg?ttc?ggg?gaa?taaaaccctg?cttatcgacg 1058

Val?Gly?Trp?Leu?Asp?Ser?Leu?Phe?Gly?Glu

340 345

ccg 1061

<210>406

<211>346

<212>PRT

＜213〉Corynebacterium glutamicum

<400>406

Glu?Gln?Asp?Leu?Asp?Glu?Leu?Met?His?Ser?Thr?Gly?Val?Ile?Asp?Pro

1 5 10 15

Leu?Thr?Gly?Ala?Pro?Lys?Ser?Ala?Ser?Lys?Pro?Gly?Trp?Thr?Ser?Val

20 25 30

Phe?Ser?Asp?Glu?Leu?Val?Lys?Ile?Gly?Ala?Gln?Asn?Glu?Asn?Val?Val

35 40 45

Ala?Ile?Thr?Ala?Ala?Met?Ala?Gly?Pro?Thr?Gly?Leu?Ser?Lys?Phe?Glu

50 55 60

Ala?Asn?Phe?Pro?Asn?Arg?Phe?Phe?Asp?Val?Gly?Ile?Ala?Glu?Gln?His

65 70 75 80

Ala?Val?Thr?Ser?Ala?Ala?Gly?Leu?Ala?Leu?Gly?Gly?Lys?His?Pro?Val

85 90 95

Val?Ala?Ile?Tyr?Ser?Thr?Phe?Leu?Asn?Arg?Ala?Phe?Asp?Gln?Leu?Leu

100 105 110

Met?Asp?Val?Gly?Met?Leu?Asn?Gln?Pro?Val?Thr?Leu?Val?Leu?Asp?Arg

115 120 125

Ser?Gly?Val?Thr?Gly?Ser?Asp?Gly?Ala?Ser?His?Asn?Gly?Val?Trp?Asp

130 135 140

Met?Ala?Leu?Thr?Ser?Ile?Val?Pro?Gly?Val?Gln?Val?Ala?Ala?Pro?Arg

145 150 155 160

Asp?Glu?Asp?Ser?Leu?Arg?Glu?Leu?Leu?Asn?Glu?Ala?Ile?Ser?Ile?Asp

165 170 175

Asp?Gly?Pro?Thr?Val?Val?Arg?Phe?Pro?Lys?Gly?Asp?Leu?Pro?Thr?Pro

180 185 190

Ile?Val?Ala?Ile?Asp?Thr?Leu?Glu?Asp?Gly?Val?Asp?Val?Leu?Ala?Tyr

195 200 205

Glu?Asp?Ala?Thr?Asp?Val?Glu?Ser?Thr?Asp?Asp?Ala?Pro?Ser?Val?Leu

210 215 220

Ile?Ile?Ala?Val?Gly?Glu?Arg?Ala?Thr?Val?Ala?Leu?Asp?Val?Ala?Ser

225 230 235 240

Arg?Ile?Lys?Gln?His?Gly?Val?Asn?Val?Thr?Val?Val?Asp?Pro?Arg?Trp

245 250 255

Ile?Val?Pro?Ile?Pro?Gln?Ser?Leu?Val?Ala?Leu?Ser?Asp?Asp?His?Asp

260 265 270

Leu?Val?Ile?Thr?Ile?Glu?Asp?Gly?Val?Ile?His?Gly?Gly?Val?Gly?Ser

275 280 285

Leu?Leu?Ser?Asp?Ala?Leu?Asn?Ala?Ser?Glu?Val?Asp?Thr?Pro?Arg?Arg

290 295 300

Gln?Ile?Ala?Val?Pro?Gln?Lys?Tyr?Leu?Asp?His?Ala?Ser?Arg?Asn?Glu

305 310 315 320

Val?Leu?Ala?Asp?Tyr?Gly?Leu?Asp?Ala?Asp?Gly?Ile?Glu?Thr?Thr?Val

325 330 335

Val?Gly?Trp?Leu?Asp?Ser?Leu?Phe?Gly?Glu

340 345

<210>407

<211>703

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(703)

<223>FRXA01705

<400>407

gcaggtgcac?atttgttttg?tcacctgcac?aaaagtgtcg?ccagcccgat?acttgtacaa?60

ccgtccgcat?ccgagaagca?aaggtgtctg?actcgcgcca?atg?gga?att?ctg?aac 115

Met?Gly?Ile?Leu?Asn

1 5

agt?att?tca?aca?cct?gct?gac?tta?aag?gcc?ctt?aat?gat?gag?gat?ttg 163

Ser?Ile?Ser?Thr?Pro?Ala?Asp?Leu?Lys?Ala?Leu?Asn?Asp?Glu?Asp?Leu

10 15 20

gac?gct?ctt?gcc?aaa?gaa?atc?cga?act?ttc?ctg?gtc?gat?aaa?gtc?gca 211

Asp?Ala?Leu?Ala?Lys?Glu?Ile?Arg?Thr?Phe?Leu?Val?Asp?Lys?Val?Ala

25 30 35

gca?act?ggt?ggc?cac?tta?ggt?cca?aat?ttg?ggc?gta?gtg?gaa?tta?acc 259

Ala?Thr?Gly?Gly?His?Leu?Gly?Pro?Asn?Leu?Gly?Val?Val?Glu?Leu?Thr

40 45 50

atc?ggt?ctt?cat?cga?gtt?ttc?gat?tcg?cct?caa?gac?ccg?atc?atc?ttt 307

Ile?Gly?Leu?His?Arg?Val?Phe?Asp?Ser?Pro?Gln?Asp?Pro?Ile?Ile?Phe

55 60 65

gat?act?tct?cac?cag?tcc?tat?gtg?cat?aag?atc?ctg?acg?ggt?cgc?gct 355

Asp?Thr?Ser?His?Gln?Ser?Tyr?Val?His?Lys?Ile?Leu?Thr?Gly?Arg?Ala

70 75 80 85

aaa?gat?ttt?gat?tct?ttg?cgt?caa?aaa?gat?ggc?ctt?tct?ggt?tac?acc 403

Lys?Asp?Phe?Asp?Ser?Leu?Arg?Gln?Lys?Asp?Gly?Leu?Ser?Gly?Tyr?Thr

90 95 100

tgc?cgt?gct?gaa?agt?gag?cac?gat?tgg?act?gag?tct?tcg?cat?gct?tcg 451

Cys?Arg?Ala?Glu?Ser?Glu?His?Asp?Trp?Thr?Glu?Ser?Ser?His?Ala?Ser

105 110 115

gcg?gcc?ttg?tct?tat?gcg?gat?ggt?ttg?tct?aaa?gcc?aag?cag?ttg?gat 499

Ala?Ala?Leu?Ser?Tyr?Ala?Asp?Gly?Leu?Ser?Lys?Ala?Lys?Gln?Leu?Asp

120 125 130

ggc?gat?acc?acg?cat?agt?gtg?gtt?gct?gtc?gtt?ggt?gat?ggc?gct?cta 547

Gly?Asp?Thr?Thr?His?Ser?Val?Val?Ala?Val?Val?Gly?Asp?Gly?Ala?Leu

135 140 145

act?ggc?ggc?atg?tgt?tgg?gaa?gca?ctg?aac?aat?att?gct?gct?ggt?aaa 595

Thr?Gly?Gly?Met?Cys?Trp?Glu?Ala?Leu?Asn?Asn?Ile?Ala?Ala?Gly?Lys

150 155 160 165

gac?cgc?aaa?gtt?gtt?gtc?gta?gtc?aat?gac?aat?ggc?cgg?agt?tat?tct 643

Asp?Arg?Lys?Val?Val?Val?Val?Val?Asn?Asp?Asn?Gly?Arg?Ser?Tyr?Ser

170 175 180

cca?acc?att?ggc?gga?ttt?gcg?gaa?aac?ctt?gcg?ggc?ctt?cgc?atg?cag 691

Pro?Thr?Ile?Gly?Gly?Phe?Ala?Glu?Asn?Leu?Ala?Gly?Leu?Arg?Met?Gln

185 190 195

cct?ttc?tat?gat 703

Pro?Phe?Tyr?Asp

200

<210>408

<211>201

<212>PRT

＜213〉Corynebacterium glutamicum

<400>408

Met?Gly?Ile?Leu?Asn?Ser?Ile?Ser?Thr?Pro?Ala?Asp?Leu?Lys?Ala?Leu

1 5 10 15

Asn?Asp?Glu?Asp?Leu?Asp?Ala?Leu?Ala?Lys?Glu?Ile?Arg?Thr?Phe?Leu

20 25 30

Val?Asp?Lys?Val?Ala?Ala?Thr?Gly?Gly?His?Leu?Gly?Pro?Asn?Leu?Gly

35 40 45

Val?Val?Glu?Leu?Thr?Ile?Gly?Leu?His?Arg?Val?Phe?Asp?Ser?Pro?Gln

50 55 60

Asp?Pro?Ile?Ile?Phe?Asp?Thr?Ser?His?Gln?Ser?Tyr?Val?His?Lys?Ile

65 70 75 80

Leu?Thr?Gly?Arg?Ala?Lys?Asp?Phe?Asp?Ser?Leu?Arg?Gln?Lys?Asp?Gly

85 90 95

Leu?Ser?Gly?Tyr?Thr?Cys?Arg?Ala?Glu?Ser?Glu?His?Asp?Trp?Thr?Glu

100 105 110

Ser?Ser?His?Ala?Ser?Ala?Ala?Leu?Ser?Tyr?Ala?Asp?Gly?Leu?Ser?Lys

115 120 125

Ala?Lys?Gln?Leu?Asp?Gly?Asp?Thr?Thr?His?Ser?Val?Val?Ala?Val?Val

130 135 140

Gly?Asp?Gly?Ala?Leu?Thr?Gly?Gly?Met?Cys?Trp?Glu?Ala?Leu?Asn?Asn

145 150 155 160

Ile?Ala?Ala?Gly?Lys?Asp?Arg?Lys?Val?Val?Val?Val?Val?Asn?Asp?Asn

165 170 175

Gly?Arg?Ser?Tyr?Ser?Pro?Thr?Ile?Gly?Gly?Phe?Ala?Glu?Asn?Leu?Ala

180 185 190

Gly?Leu?Arg?Met?Gln?Pro?Phe?Tyr?Asp

195 200

<210>409

<211>2241

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(2218)

<223>RXN00879

<400>409

caccccaaag?cccaatccaa?aagatgtatt?ttctaacaaa?cttaccctca?cgctacaaat?60

atgctgtgcc?cacacgctat?tagtggcata?atgttgtgtt?gtg?act?gct?cgc?aga 115

Val?Thr?Ala?Arg?Arg

1 5

ttt?ttg?aat?gaa?ctc?gcc?gat?ctc?tac?ggc?gta?gca?act?tcc?tac?act 163

Phe?Leu?Asn?Glu?Leu?Ala?Asp?Leu?Tyr?Gly?Val?Ala?Thr?Ser?Tyr?Thr

10 15 20

gat?tac?aaa?ggt?gcc?cat?att?gag?gtc?agc?gat?gac?aca?tta?gtg?aaa 211

Asp?Tyr?Lys?Gly?Ala?His?Ile?Glu?Val?Ser?Asp?Asp?Thr?Leu?Val?Lys

25 30 35

atc?ctg?cgt?gct?ctg?ggt?gtg?aat?tta?gat?aca?agc?aac?ctc?ccc?aac 259

Ile?Leu?Arg?Ala?Leu?Gly?Val?Asn?Leu?Asp?Thr?Ser?Asn?Leu?Pro?Asn

40 45 50

gat?gac?gct?atc?caa?cgc?caa?att?gcc?ctc?ttc?cat?gat?cga?gag?ttc 307

Asp?Asp?Ala?Ile?Gln?Arg?Gln?Ile?Ala?Leu?Phe?His?Asp?Arg?Glu?Phe

55 60 65

act?cgc?cca?ctg?cct?cca?tcg?gtg?gtt?gca?gtt?gaa?ggt?gat?gaa?cta 355

Thr?Arg?Pro?Leu?Pro?Pro?Ser?Val?Val?Ala?Val?Glu?Gly?Asp?Glu?Leu

70 75 80 85

gtt?ttc?ccg?gtg?cat?gtg?cac?gac?ggt?tcc?cct?gca?gat?gtc?cac?atc 403

Val?Phe?Pro?Val?His?Val?His?Asp?Gly?Ser?Pro?Ala?Asp?Val?His?Ile

90 95 100

gaa?ttg?gaa?gac?ggc?acg?cag?cgg?gat?gtt?tct?cag?gtg?gaa?aac?tgg 451

Glu?Leu?Glu?Asp?Gly?Thr?Gln?Arg?Asp?Val?Ser?Gln?Val?Glu?Asn?Trp

105 110 115

aca?gcg?cca?cgg?gaa?att?gat?ggg?att?agg?tgg?ggc?gag?gca?tcg?ttt 499

Thr?Ala?Pro?Arg?Glu?Ile?Asp?Gly?Ile?Arg?Trp?Gly?Glu?Ala?Ser?Phe

120 125 130

aag?att?cct?ggt?gat?ctc?ccc?ttg?ggt?tgg?cac?aag?ctt?cac?ctt?aaa 547

Lys?Ile?Pro?Gly?Asp?Leu?Pro?Leu?Gly?Trp?His?Lys?Leu?His?Leu?Lys

135 140 145

tcc?aat?gaa?cgc?tca?gct?gag?tgc?ggt?ttg?atc?atc?acc?ccg?gct?cgt 595

Ser?Asn?Glu?Arg?Ser?Ala?Glu?Cys?Gly?Leu?Ile?Ile?Thr?Pro?Ala?Arg

150 155 160 165

ctg?tct?act?gct?gat?aag?tat?ctt?gat?tcc?cct?cgc?agt?ggt?gtc?atg 643

Leu?Ser?Thr?Ala?Asp?Lys?Tyr?Leu?Asp?Ser?Pro?Arg?Ser?Gly?Val?Met

170 175 180

gcg?cag?atc?tac?tct?gtg?cgt?tcc?acg?ttg?tcg?tgg?ggc?atg?ggt?gat 691

Ala?Gln?Ile?Tyr?Ser?Val?Arg?Ser?Thr?Leu?Ser?Trp?Gly?Met?Gly?Asp

185 190 195

ttc?aat?gat?tta?gga?aac?ttg?gca?agt?gtg?gtt?gcc?cag?gat?gga?gca 739

Phe?Asn?Asp?Leu?Gly?Asn?Leu?Ala?Ser?Val?Val?Ala?Gln?Asp?Gly?Ala

200 205 210

gac?ttc?ctg?ctc?atc?aac?ccc?atg?cac?gct?gca?gag?ccg?ctg?cct?cct 787

Asp?Phe?Leu?Leu?Ile?Asn?Pro?Met?His?Ala?Ala?Glu?Pro?Leu?Pro?Pro

215 220 225

act?gag?gac?tct?cct?tat?ctg?ccc?aca?acc?agg?cgc?ttt?atc?aac?ccg 835

Thr?Glu?Asp?Ser?Pro?Tyr?Leu?Pro?Thr?Thr?Arg?Arg?Phe?Ile?Asn?Pro

230 235 240 245

atc?tac?att?cgg?gta?gaa?gat?att?ccg?gag?ttt?aat?cag?ctt?gag?att 883

Ile?Tyr?Ile?Arg?Val?Glu?Asp?Ile?Pro?Glu?Phe?Asn?Gln?Leu?Glu?Ile

250 255 260

gat?cta?cgc?gat?gat?atc?gca?gag?atg?gct?gcg?gaa?ttc?cgc?gaa?cgc 931

Asp?Leu?Arg?Asp?Asp?Ile?Ala?Glu?Met?Ala?Ala?Glu?Phe?Arg?Glu?Arg

265 270 275

aat?ctg?acc?tca?gac?atc?att?gag?cgc?aat?gac?gtc?tac?gct?gca?aag 979

Asn?Leu?Thr?Ser?Asp?Ile?Ile?Glu?Arg?Asn?Asp?Val?Tyr?Ala?Ala?Lys

280 285 290

ctt?caa?gtg?ctg?cgc?gcc?att?ttt?gaa?atg?cct?cgt?tcc?agc?gaa?cgt 1027

Leu?Gln?Val?Leu?Arg?Ala?Ile?Phe?Glu?Met?Pro?Arg?Ser?Ser?Glu?Arg

295 300 305

gaa?gcc?aac?ttt?gtc?tcc?ttc?gtg?caa?cgg?gaa?ggc?caa?ggt?ctt?att 1075

Glu?Ala?Asn?Phe?Val?Ser?Phe?Val?Gln?Arg?Glu?Gly?Gln?Gly?Leu?Ile

310 315 320 325

gat?ttc?gcc?acc?tgg?tgc?gcg?gac?cgc?gaa?act?gca?cag?tct?gaa?tct 1123

Asp?Phe?Ala?Thr?Trp?Cys?Ala?Asp?Arg?Glu?Thr?Ala?Gln?Ser?Glu?Ser

330 335 340

gtc?cac?gga?act?gag?cca?gac?cgc?gat?gag?ctg?acc?atg?ttc?tac?atg 1171

Val?His?Gly?Thr?Glu?Pro?Asp?Arg?Asp?Glu?Leu?Thr?Met?Phe?Tyr?Met

345 350 355

tgg?ttg?cag?tgg?cta?tgt?gat?gag?cag?ctg?gcg?gca?gct?caa?aag?cgc 1219

Trp?Leu?Gln?Trp?Leu?Cys?Asp?Glu?Gln?Leu?Ala?Ala?Ala?Gln?Lys?Arg

360 365 370

gct?gtc?gat?gcc?gga?atg?tcg?atc?ggc?atc?atg?gca?gac?ctg?gca?gtt 1267

Ala?Val?Asp?Ala?Gly?Met?Ser?Ile?Gly?Ile?Met?Ala?Asp?Leu?Ala?Val

375 380 385

ggt?gtg?cat?cca?ggt?ggt?gct?gat?gcc?cag?aac?ctc?agc?cac?gta?ctt 1315

Gly?Val?His?Pro?Gly?Gly?Ala?Asp?Ala?Gln?Asn?Leu?Ser?His?Val?Leu

390 395 400 405

gct?ccg?gat?gcg?tca?gtg?ggc?gcc?cca?cca?gat?gga?tac?aac?cag?cag 1363

Ala?Pro?Asp?Ala?Ser?Val?Gly?Ala?Pro?Pro?Asp?Gly?Tyr?Asn?Gln?Gln

410 415 420

ggc?caa?gac?tgg?tcc?cag?cca?cca?tgg?cat?cca?gtg?cgt?ctt?gca?gag 1411

Gly?Gln?Asp?Trp?Ser?Gln?Pro?Pro?Trp?His?Pro?Val?Arg?Leu?Ala?Glu

425 430 435

gaa?ggc?tac?att?ccg?tgg?cgt?aat?ctg?ctg?cgc?act?gtg?ctg?cgt?cac 1459

Glu?Gly?Tyr?Ile?Pro?Trp?Arg?Asn?Leu?Leu?Arg?Thr?Val?Leu?Arg?His

440 445 450

tcc?ggc?gga?atc?cgc?gtg?gac?cac?gtt?ctt?ggt?ttg?ttc?agg?ctc?ttt 1507

Ser?Gly?Gly?Ile?Arg?Val?Asp?His?Val?Leu?Gly?Leu?Phe?Arg?Leu?Phe

455 460 465

gtc?atg?cca?cgc?atg?caa?tcc?cct?gct?acg?ggc?acc?tat?atc?cgc?ttc 1555

Val?Met?Pro?Arg?Met?Gln?Ser?Pro?Ala?Thr?Gly?Thr?Tyr?Ile?Arg?Phe

470 475 480 485

gac?cat?aat?gcg?ttg?gta?ggc?att?cta?gcc?cta?gaa?gca?gaa?ctc?gca 1603

Asp?His?Asn?Ala?Leu?Val?Gly?Ile?Leu?Ala?Leu?Glu?Ala?Glu?Leu?Ala

490 495 500

ggc?gcc?gtt?gtc?att?ggt?gaa?gat?ctg?gga?acg?ttt?gag?cct?tgg?gta 1651

Gly?Ala?Val?Val?Ile?Gly?Glu?Asp?Leu?Gly?Thr?Phe?Glu?Pro?Trp?Val

505 510 515

caa?gat?gca?ttg?gct?cag?cgt?ggc?atc?atg?ggc?acc?tcg?atc?cta?tgg 1699

Gln?Asp?Ala?Leu?Ala?Gln?Arg?Gly?Ile?Met?Gly?Thr?Ser?Ile?Leu?Trp

520 525 530

ttc?gag?cat?tcc?cca?agc?cag?ccg?ggt?cct?cgc?cgc?cag?gaa?gag?tat 1747

Phe?Glu?His?Ser?Pro?Ser?Gln?Pro?Gly?Pro?Arg?Arg?Gln?Glu?Glu?Tyr

535 540 545

cgt?ccg?ctg?gcc?ttg?acc?act?gtg?acc?act?cat?gat?ctc?cct?ccg?act 1795

Arg?Pro?Leu?Ala?Leu?Thr?Thr?Val?Thr?Thr?His?Asp?Leu?Pro?Pro?Thr

550 555 560 565

gct?ggt?tat?ttg?gag?ggc?gag?cac?att?gct?ctt?cgt?gag?cga?ttg?ggg 1843

Ala?Gly?Tyr?Leu?Glu?Gly?Glu?His?Ile?Ala?Leu?Arg?Glu?Arg?Leu?Gly

570 575 580

gtg?ctc?aac?act?gat?cct?gct?gca?gaa?ctc?gct?gag?gat?ctg?cag?tgg 1891

Val?Leu?Asn?Thr?Asp?Pro?Ala?Ala?Glu?Leu?Ala?Glu?Asp?Leu?Gln?Trp

585 590 595

caa?gcg?gag?atc?ctt?gat?gtc?gca?gca?tct?gcc?aac?gca?ttg?cca?gcc 1939

Gln?Ala?Glu?Ile?Leu?Asp?Val?Ala?Ala?Ser?Ala?Asn?Ala?Leu?Pro?Ala

600 605 610

cgg?gaa?tac?gtg?gga?ctc?gaa?cgc?gat?cag?cgc?ggt?gag?ttg?gct?gag 1987

Arg?Glu?Tyr?Val?Gly?Leu?Glu?Arg?Asp?Gln?Arg?Gly?Glu?Leu?Ala?Glu

615 620 625

ctg?ttg?gaa?ggc?ctg?cac?act?ttc?gtt?gcg?aaa?acc?cct?tca?gca?ctg 2035

Leu?Leu?Glu?Gly?Leu?His?Thr?Phe?Val?Ala?Lys?Thr?Pro?Ser?Ala?Leu

630 635 640 645

acc?tgt?gtc?tgc?ttg?gta?gac?atg?gtc?ggt?gaa?aag?cgg?gca?cag?aat 2083

Thr?Cys?Val?Cys?Leu?Val?Asp?Met?Val?Gly?Glu?Lys?Arg?Ala?Gln?Asn

650 655 660

cag?ccg?ggc?aca?acg?agg?gat?atg?tat?ccc?aac?tgg?tgt?atc?cca?ctg 2131

Gln?Pro?Gly?Thr?Thr?Arg?Asp?Met?Tyr?Pro?Asn?Trp?Cys?Ile?Pro?Leu

665 670 675

tgt?gac?agc?gaa?ggc?aac?tcc?gtg?ctc?att?gaa?tcg?ctg?cgt?gaa?aat 2179

Cys?Asp?Ser?Glu?Gly?Asn?Ser?Val?Leu?Ile?Glu?Ser?Leu?Arg?Glu?Asn

680 685 690

gag?ctg?tat?cac?cgt?gtg?gca?aag?gca?agc?aag?cga?gat?taggtccgct 2228

Glu?Leu?Tyr?His?Arg?Val?Ala?Lys?Ala?Ser?Lys?Arg?Asp

695 700 705

tcagttgtgg?tgg 2241

<210>410

<211>706

<212>PRT

＜213〉Corynebacterium glutamicum

<400>410

Val?Thr?Ala?Arg?Arg?Phe?Leu?Asn?Glu?Leu?Ala?Asp?Leu?Tyr?Gly?Val

1 5 10 15

Ala?Thr?Ser?Tyr?Thr?Asp?Tyr?Lys?Gly?Ala?His?Ile?Glu?Val?Ser?Asp

20 25 30

Asp?Thr?Leu?Val?Lys?Ile?Leu?Arg?Ala?Leu?Gly?Val?Asn?Leu?Asp?Thr

35 40 45

Ser?Asn?Leu?Pro?Asn?Asp?Asp?Ala?Ile?Gln?Arg?Gln?Ile?Ala?Leu?Phe

50 55 60

His?Asp?Arg?Glu?Phe?Thr?Arg?Pro?Leu?Pro?Pro?Ser?Val?Val?Ala?Val

65 70 75 80

Glu?Gly?Asp?Glu?Leu?Val?Phe?Pro?Val?His?Val?His?Asp?Gly?Ser?Pro

85 90 95

Ala?Asp?Val?His?Ile?Glu?Leu?Glu?Asp?Gly?Thr?Gln?Arg?Asp?Val?Ser

100 105 110

Gln?Val?Glu?Asn?Trp?Thr?Ala?Pro?Arg?Glu?Ile?Asp?Gly?Ile?Arg?Trp

115 120 125

Gly?Glu?Ala?Ser?Phe?Lys?Ile?Pro?Gly?Asp?Leu?Pro?Leu?Gly?Trp?His

130 135 140

Lys?Leu?His?Leu?Lys?Ser?Asn?Glu?Arg?Ser?Ala?Glu?Cys?Gly?Leu?Ile

145 150 155 160

Ile?Thr?Pro?Ala?Arg?Leu?Ser?Thr?Ala?Asp?Lys?Tyr?Leu?Asp?Ser?Pro

165 170 175

Arg?Ser?Gly?Val?Met?Ala?Gln?Ile?Tyr?Ser?Val?Arg?Ser?Thr?Leu?Ser

180 185 190

Trp?Gly?Met?Gly?Asp?Phe?Asn?Asp?Leu?Gly?Asn?Leu?Ala?Ser?Val?Val

195 200 205

Ala?Gln?Asp?Gly?Ala?Asp?Phe?Leu?Leu?Ile?Asn?Pro?Met?His?Ala?Ala

210 215 220

Glu?Pro?Leu?Pro?Pro?Thr?Glu?Asp?Ser?Pro?Tyr?Leu?Pro?Thr?Thr?Arg

225 230 235 240

Arg?Phe?Ile?Asn?Pro?Ile?Tyr?Ile?Arg?Val?Glu?Asp?Ile?Pro?Glu?Phe

245 250 255

Asn?Gln?Leu?Glu?Ile?Asp?Leu?Arg?Asp?Asp?Ile?Ala?Glu?Met?Ala?Ala

260 265 270

Glu?Phe?Arg?Glu?Arg?Asn?Leu?Thr?Ser?Asp?Ile?Ile?Glu?Arg?Asn?Asp

275 280 285

Val?Tyr?Ala?Ala?Lys?Leu?Gln?Val?Leu?Arg?Ala?Ile?Phe?Glu?Met?Pro

290 295 300

Arg?Ser?Ser?Glu?Arg?Glu?Ala?Asn?Phe?Val?Ser?Phe?Val?Gln?Arg?Glu

305 310 315 320

Gly?Gln?Gly?Leu?Ile?Asp?Phe?Ala?Thr?Trp?Cys?Ala?Asp?Arg?Glu?Thr

325 330 335

Ala?Gln?Ser?Glu?Ser?Val?His?Gly?Thr?Glu?Pro?Asp?Arg?Asp?Glu?Leu

340 345 350

Thr?Met?Phe?Tyr?Met?Trp?Leu?Gln?Trp?Leu?Cys?Asp?Glu?Gln?Leu?Ala

355 360 365

Ala?Ala?Gln?Lys?Arg?Ala?Val?Asp?Ala?Gly?Met?Ser?Ile?Gly?Ile?Met

370 375 380

Ala?Asp?Leu?Ala?Val?Gly?Val?His?Pro?Gly?Gly?Ala?Asp?Ala?Gln?Asn

385 390 395 400

Leu?Ser?His?Val?Leu?Ala?Pro?Asp?Ala?Ser?Val?Gly?Ala?Pro?Pro?Asp

405 410 415

Gly?Tyr?Asn?Gln?Gln?Gly?Gln?Asp?Trp?Ser?Gln?Pro?Pro?Trp?His?Pro

420 425 430

Val?Arg?Leu?Ala?Glu?Glu?Gly?Tyr?Ile?Pro?Trp?Arg?Asn?Leu?Leu?Arg

435 440 445

Thr?Val?Leu?Arg?His?Ser?Gly?Gly?Ile?Arg?Val?Asp?His?Val?Leu?Gly

450 455 460

Leu?Phe?Arg?Leu?Phe?Val?Met?Pro?Arg?Met?Gln?Ser?Pro?Ala?Thr?Gly

465 470 475 480

Thr?Tyr?Ile?Arg?Phe?Asp?His?Asn?Ala?Leu?Val?Gly?Ile?Leu?Ala?Leu

485 490 495

Glu?Ala?Glu?Leu?Ala?Gly?Ala?Val?Val?Ile?Gly?Glu?Asp?Leu?Gly?Thr

500 505 510

Phe?Glu?Pro?Trp?Val?Gln?Asp?Ala?Leu?Ala?Gln?Arg?Gly?Ile?Met?Gly

515 520 525

Thr?Ser?Ile?Leu?Trp?Phe?Glu?His?Ser?Pro?Ser?Gln?Pro?Gly?Pro?Arg

530 535 540

Arg?Gln?Glu?Glu?Tyr?Arg?Pro?Leu?Ala?Leu?Thr?Thr?Val?Thr?Thr?His

545 550 555 560

Asp?Leu?Pro?Pro?Thr?Ala?Gly?Tyr?Leu?Glu?Gly?Glu?His?Ile?Ala?Leu

565 570 575

Arg?Glu?Arg?Leu?Gly?Val?Leu?Asn?Thr?Asp?Pro?Ala?Ala?Glu?Leu?Ala

580 585 590

Glu?Asp?Leu?Gln?Trp?Gln?Ala?Glu?Ile?Leu?Asp?Val?Ala?Ala?Ser?Ala

595 600 605

Asn?Ala?Leu?Pro?Ala?Arg?Glu?Tyr?Val?Gly?Leu?Glu?Arg?Asp?Gln?Arg

610 615 620

Gly?Glu?Leu?Ala?Glu?Leu?Leu?Glu?Gly?Leu?His?Thr?Phe?Val?Ala?Lys

625 630 635 640

Thr?Pro?Ser?Ala?Leu?Thr?Cys?Val?Cys?Leu?Val?Asp?Met?Val?Gly?Glu

645 650 655

Lys?Arg?Ala?Gln?Asn?Gln?Pro?Gly?Thr?Thr?Arg?Asp?Met?Tyr?Pro?Asn

660 665 670

Trp?Cys?Ile?Pro?Leu?Cys?Asp?Ser?Glu?Gly?Asn?Ser?Val?Leu?Ile?Glu

675 680 685

Ser?Leu?Arg?Glu?Asn?Glu?Leu?Tyr?His?Arg?Val?Ala?Lys?Ala?Ser?Lys

690 695 700

Arg?Asp

705

<210>411

<211>2223

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(2200)

<223>FRXA00879

<400>411

aaaagatgta?ttttctaaca?aacttaccct?cacgctacaa?atatgctgtg?cccacacgct?60

attagtggca?taatgttgtg?ttgtgactgc?tcgcagattt?ttg?aat?gaa?ctc?gcc 115

Leu?Asn?Glu?Leu?Ala

1 5

gat?ctc?tac?ggc?gta?gca?act?tcc?tac?act?gat?tac?aaa?ggt?gcc?cat 163

Asp?Leu?Tyr?Gly?Val?Ala?Thr?Ser?Tyr?Thr?Asp?Tyr?Lys?Gly?Ala?His

10 15 20

att?gag?gtc?agc?gat?gac?aca?tta?gtg?aaa?atc?ctg?cgt?gct?ctg?ggt 211

Ile?Glu?Val?Ser?Asp?Asp?Thr?Leu?Val?Lys?Ile?Leu?Arg?Ala?Leu?Gly

25 30 35

gtg?aat?tta?gat?aca?agc?aac?ctc?ccc?aac?gat?gac?gct?atc?caa?cgc 259

Val?Asn?Leu?Asp?Thr?Ser?Asn?Leu?Pro?Asn?Asp?Asp?Ala?Ile?Gln?Arg

40 45 50

caa?att?gcc?ctc?ttc?cat?gat?cga?gag?ttc?act?cgc?cca?ctg?cct?cca 307

Gln?Ile?Ala?Leu?Phe?His?Asp?Arg?Glu?Phe?Thr?Arg?Pro?Leu?Pro?Pro

55 60 65

tcg?gtg?gtt?gca?gtt?gaa?ggt?gat?gaa?cta?gtt?ttc?ccg?gtg?cat?gtg 355

Ser?Val?Val?Ala?Val?Glu?Gly?Asp?Glu?Leu?Val?Phe?Pro?Val?His?Val

70 75 80 85

cac?gac?ggt?tcc?cct?gca?gat?gtc?cac?atc?gaa?ttg?gaa?gac?ggc?acg 403

His?Asp?Gly?Ser?Pro?Ala?Asp?Val?His?Ile?Glu?Leu?Glu?Asp?Gly?Thr

90 95 100

cag?cgg?gat?gtt?tct?cag?gtg?gaa?aac?tgg?aca?gcg?cca?cgg?gaa?att 451

Gln?Arg?Asp?Val?Ser?Gln?Val?Glu?Asn?Trp?Thr?Ala?Pro?Arg?Glu?Ile

105 110 115

gat?ggg?att?agg?tgg?ggc?gag?gca?tcg?ttt?aag?att?cct?ggt?gat?ctc 499

Asp?Gly?Ile?Arg?Trp?Gly?Glu?Ala?Ser?Phe?Lys?Ile?Pro?Gly?Asp?Leu

120 125 130

ccc?ttg?ggt?tgg?cac?aag?ctt?cac?ctt?aaa?tcc?aat?gaa?cgc?tca?gct 547

Pro?Leu?Gly?Trp?His?Lys?Leu?His?Leu?Lys?Ser?Asn?Glu?Arg?Ser?Ala

135 140 145

gag?tgc?ggt?ttg?atc?atc?acc?ccg?gct?cgt?ctg?tct?act?gct?gat?aag 595

Glu?Cys?Gly?Leu?Ile?Ile?Thr?Pro?Ala?Arg?Leu?Ser?Thr?Ala?Asp?Lys

150 155 160 165

tat?ctt?gat?tcc?cct?cgc?agt?ggt?gtc?atg?gcg?cag?atc?tac?tct?gtg 643

Tyr?Leu?Asp?Ser?Pro?Arg?Ser?Gly?Val?Met?Ala?Gln?Ile?Tyr?Ser?Val

170 175 180

cgt?tcc?acg?ttg?tcg?tgg?ggc?atg?ggt?gat?ttc?aat?gat?tta?gga?aac 691

Arg?Ser?Thr?Leu?Ser?Trp?Gly?Met?Gly?Asp?Phe?Asn?Asp?Leu?Gly?Asn

185 190 195

ttg?gca?agt?gtg?gtt?gcc?cag?gat?gga?gca?gac?ttc?ctg?ctc?atc?aac 739

Leu?Ala?Ser?Val?Val?Ala?Gln?Asp?Gly?Ala?Asp?Phe?Leu?Leu?Ile?Asn

200 205 210

ccc?atg?cac?gct?gca?gag?ccg?ctg?cct?cct?act?gag?gac?tct?cct?tat 787

Pro?Met?His?Ala?Ala?Glu?Pro?Leu?Pro?Pro?Thr?Glu?Asp?Ser?Pro?Tyr

215 220 225

ctg?ccc?aca?acc?agg?cgc?ttt?atc?aac?ccg?atc?tac?att?cgg?gta?gaa 835

Leu?Pro?Thr?Thr?Arg?Arg?Phe?Ile?Asn?Pro?Ile?Tyr?Ile?Arg?Val?Glu

230 235 240 245

gat?att?ccg?gag?ttt?aat?cag?ctt?gag?att?gat?cta?cgc?gat?gat?atc 883

Asp?Ile?Pro?Glu?Phe?Asn?Gln?Leu?Glu?Ile?Asp?Leu?Arg?Asp?Asp?Ile

250 255 260

gca?gag?atg?gct?gcg?gaa?ttc?cgc?gaa?cgc?aat?ctg?acc?tca?gac?atc 931

Ala?Glu?Met?Ala?Ala?Glu?Phe?Arg?Glu?Arg?Asn?Leu?Thr?Ser?Asp?Ile

265 270 275

att?gag?cgc?aat?gac?gtc?tac?gct?gca?aag?ctt?caa?gtg?ctg?cgc?gcc 979

Ile?Glu?Arg?Asn?Asp?Val?Tyr?Ala?Ala?Lys?Leu?Gln?Val?Leu?Arg?Ala

280 285 290

att?ttt?gaa?atg?cct?cgt?tcc?agc?gaa?cgt?gaa?gcc?aac?ttt?gtc?tcc 1027

Ile?Phe?Glu?Met?Pro?Arg?Ser?Ser?Glu?Arg?Glu?Ala?Asn?Phe?Val?Ser

295 300 305

ttc?gtg?caa?cgg?gaa?ggc?caa?ggt?ctt?att?gat?ttc?gcc?acc?tgg?tgc 1075

Phe?Val?Gln?Arg?Glu?Gly?Gln?Gly?Leu?Ile?Asp?Phe?Ala?Thr?Trp?Cys

310 315 320 325

gcg?gac?cgc?gaa?act?gca?cag?tct?gaa?tct?gtc?cac?gga?act?gag?cca 1123

Ala?Asp?Arg?Glu?Thr?Ala?Gln?Ser?Glu?Ser?Val?His?Gly?Thr?Glu?Pro

330 335 340

gac?cgc?gat?gag?ctg?acc?atg?ttc?tac?atg?tgg?ttg?cag?tgg?cta?tgt 1171

Asp?Arg?Asp?Glu?Leu?Thr?Met?Phe?Tyr?Met?Trp?Leu?Gln?Trp?Leu?Cys

345 350 355

gat?gag?cag?ctg?gcg?gca?gct?caa?aag?cgc?gct?gtc?gat?gcc?gga?atg 1219

Asp?Glu?Gln?Leu?Ala?Ala?Ala?Gln?Lys?Arg?Ala?Val?Asp?Ala?Gly?Met

360 365 370

tcg?atc?ggc?atc?atg?gca?gac?ctg?gca?gtt?ggt?gtg?cat?cca?ggt?ggt 1267

Ser?Ile?Gly?Ile?Met?Ala?Asp?Leu?Ala?Val?Gly?Val?His?Pro?Gly?Gly

375 380 385

gct?gat?gcc?cag?aac?ctc?agc?cac?gta?ctt?gct?ccg?gat?gcg?tca?gtg 1315

Ala?Asp?Ala?Gln?Asn?Leu?Set?His?Val?Leu?Ala?Pro?Asp?Ala?Ser?Val

390 395 400 405

ggc?gcc?cca?cca?gat?gga?tac?aac?cag?cag?ggc?caa?gac?tgg?tcc?cag 1363

Gly?Ala?Pro?Pro?Asp?Gly?Tyr?Asn?Gln?Gln?Gly?Gln?Asp?Trp?Ser?Gln

410 415 420

cca?cca?tgg?cat?cca?gtg?cgt?ctt?gca?gag?gaa?ggc?tac?att?ccg?tgg 1411

Pro?Pro?Trp?His?Pro?Val?Arg?Leu?Ala?Glu?Glu?Gly?Tyr?Ile?Pro?Trp

425 430 435

cgt?aat?ctg?ctg?cgc?act?gtg?ctg?cgt?cac?tcc?ggc?gga?atc?cgc?gtg 1459

Arg?Asn?Leu?Leu?Arg?Thr?Val?Leu?Arg?His?Ser?Gly?Gly?Ile?Arg?Val

440 445 450

gac?cac?gtt?ctt?ggt?ttg?ttc?agg?ctc?ttt?gtc?atg?cca?cgc?atg?caa 1507

Asp?His?Val?Leu?Gly?Leu?Phe?Arg?Leu?Phe?Val?Met?Pro?Arg?Met?Gln

455 460 465

tcc?cct?gct?acg?ggc?acc?tat?atc?cgc?ttc?gac?cat?aat?gcg?ttg?gta 1555

Ser?Pro?Ala?Thr?Gly?Thr?Tyr?Ile?Arg?Phe?Asp?His?Asn?Ala?Leu?Val

470 475 480 485

ggc?att?cta?gcc?cta?gaa?gca?gaa?ctc?gca?ggc?gcc?gtt?gtc?att?ggt 1603

Gly?Ile?Leu?Ala?Leu?Glu?Ala?Glu?Leu?Ala?Gly?Ala?Val?Val?Ile?Gly

490 495 500

gaa?gat?ctg?gga?acg?ttt?gag?cct?tgg?gta?caa?gat?gca?ttg?gct?cag 1651

Glu?Asp?Leu?Gly?Thr?Phe?Glu?Pro?Trp?Val?Gln?Asp?Ala?Leu?Ala?Gln

505 510 515

cgt?ggc?atc?atg?ggc?acc?tcg?atc?cta?tgg?ttc?gag?cat?tcc?cca?agc 1699

Arg?Gly?Ile?Met?Gly?Thr?Ser?Ile?Leu?Trp?Phe?Glu?His?Ser?Pro?Ser

520 525 530

cag?ccg?ggt?cct?cgc?cgc?cag?gaa?gag?tat?cgt?ccg?ctg?gcc?ttg?acc 1747

Gln?Pro?Gly?Pro?Arg?Arg?Gln?Glu?Glu?Tyr?Arg?Pro?Leu?Ala?Leu?Thr

535 540 545

act?gtg?acc?act?cat?gat?ctc?cct?ccg?act?gct?ggt?tat?ttg?gag?ggc 1795

Thr?Val?Thr?Thr?His?Asp?Leu?Pro?Pro?Thr?Ala?Gly?Tyr?Leu?Glu?Gly

550 555 560 565

gag?cac?att?gct?ctt?cgt?gag?cga?ttg?ggg?gtg?ctc?aac?act?gat?cct 1843

Glu?His?Ile?Ala?Leu?Arg?Glu?Arg?Leu?Gly?Val?Leu?Asn?Thr?Asp?Pro

570 575 580

gct?gca?gaa?ctc?gct?gag?gat?ctg?cag?tgg?caa?gcg?gag?atc?ctt?gat 1891

Ala?Ala?Glu?Leu?Ala?Glu?Asp?Leu?Gln?Trp?Gln?Ala?Glu?Ile?Leu?Asp

585 590 595

gtc?gca?gca?tct?gcc?aac?gca?ttg?cca?gcc?cgg?gaa?tac?gtg?gga?ctc 1939

Val?Ala?Ala?Ser?Ala?Asn?Ala?Leu?Pro?Ala?Arg?Glu?Tyr?Val?Gly?Leu

600 605 610

gaa?cgc?gat?cag?cgc?ggt?gag?ttg?gct?gag?ctg?ttg?gaa?ggc?ctg?cac 1987

Glu?Arg?Asp?Gln?Arg?Gly?Glu?Leu?Ala?Glu?Leu?Leu?Glu?Gly?Leu?His

615 620 625

act?ttc?gtt?gcg?aaa?acc?cct?tca?gca?ctg?acc?tgt?gtc?tgc?ttg?gta 2035

Thr?Phe?Val?Ala?Lys?Thr?Pro?Ser?Ala?Leu?Thr?Cys?Val?Cys?Leu?Val

630 635 640 645

gac?atg?gtc?ggt?gaa?aag?cgg?gca?cag?aat?cag?ccg?ggc?aca?acg?agg 2083

Asp?Met?Val?Gly?Glu?Lys?Arg?Ala?Gln?Asn?Gln?Pro?Gly?Thr?Thr?Arg

650 655 660

gat?atg?tat?ccc?aac?tgg?tgt?atc?cca?ctg?tgt?gac?agc?gaa?ggc?aac 2131

Asp?Met?Tyr?Pro?Asn?Trp?Cys?Ile?Pro?Leu?Cys?Asp?Ser?Glu?Gly?Asn

665 670 675

tcc?gtg?ctc?att?gaa?tcg?ctg?cgt?gaa?aat?gag?ctg?tat?cac?cgt?gtg 2179

Ser?Val?Leu?Ile?Glu?Ser?Leu?Arg?Glu?Asn?Glu?Leu?Tyr?His?Arg?Val

680 685 690

gca?aag?gca?agc?aag?cga?gat?taggtccgct?tcagttgtgg?tgg 2223

Ala?Lys?Ala?Ser?Lys?Arg?Asp

695 700

<210>412

<211>700

<212>PRT

＜213〉Corynebacterium glutamicum

<400>412

Leu?Asn?Glu?Leu?Ala?Asp?Leu?Tyr?Gly?Val?Ala?Thr?Ser?Tyr?Thr?Asp

1 5 10 15

Tyr?Lys?Gly?Ala?His?Ile?Glu?Val?Ser?Asp?Asp?Thr?Leu?Val?Lys?Ile

20 25 30

Leu?Arg?Ala?Leu?Gly?Val?Asn?Leu?Asp?Thr?Ser?Asn?Leu?Pro?Asn?Asp

35 40 45

Asp?Ala?Ile?Gln?Arg?Gln?Ile?Ala?Leu?Phe?His?Asp?Arg?Glu?Phe?Thr

50 55 60

Arg?Pro?Leu?Pro?Pro?Ser?Val?Val?Ala?Val?Glu?Gly?Asp?Glu?Leu?Val

65 70 75 80

Phe?Pro?Val?His?Val?His?Asp?Gly?Ser?Pro?Ala?Asp?Val?His?Ile?Glu

85 90 95

Leu?Glu?Asp?Gly?Thr?Gln?Arg?Asp?Val?Ser?Gln?Val?Glu?Asn?Trp?Thr

100 105 110

Ala?Pro?Arg?Glu?Ile?Asp?Gly?Ile?Arg?Trp?Gly?Glu?Ala?Ser?Phe?Lys

115 120 125

Ile?Pro?Gly?Asp?Leu?Pro?Leu?Gly?Trp?His?Lys?Leu?His?Leu?Lys?Ser

130 135 140

Asn?Glu?Arg?Ser?Ala?Glu?Cys?Gly?Leu?Ile?Ile?Thr?Pro?Ala?Arg?Leu

145 150 155 160

Ser?Thr?Ala?Asp?Lys?Tyr?Leu?Asp?Ser?Pro?Arg?Ser?Gly?Val?Met?Ala

165 170 175

Gln?Ile?Tyr?Ser?Val?Arg?Ser?Thr?Leu?Ser?Trp?Gly?Met?Gly?Asp?Phe

180 185 190

Asn?Asp?Leu?Gly?Asn?Leu?Ala?Ser?Val?Val?Ala?Gln?Asp?Gly?Ala?Asp

195 200 205

Phe?Leu?Leu?Ile?Asn?Pro?Met?His?Ala?Ala?Glu?Pro?Leu?Pro?Pro?Thr

210 215 220

Glu?Asp?Ser?Pro?Tyr?Leu?Pro?Thr?Thr?Arg?Arg?Phe?Ile?Asn?Pro?Ile

225 230 235 240

Tyr?Ile?Arg?Val?Glu?Asp?Ile?Pro?Glu?Phe?Asn?Gln?Leu?Glu?Ile?Asp

245 250 255

Leu?Arg?Asp?Asp?Ile?Ala?Glu?Met?Ala?Ala?Glu?Phe?Arg?Glu?Arg?Asn

260 265 270

Leu?Thr?Ser?Asp?Ile?Ile?Glu?Arg?Asn?Asp?Val?Tyr?Ala?Ala?Lys?Leu

275 280 285

Gln?Val?Leu?Arg?Ala?Ile?Phe?Glu?Met?Pro?Arg?Ser?Ser?Glu?Arg?Glu

290 295 300

Ala?Asn?Phe?Val?Ser?Phe?Val?Gln?Arg?Glu?Gly?Gln?Gly?Leu?Ile?Asp

305 310 315 320

Phe?Ala?Thr?Trp?Cys?Ala?Asp?Arg?Glu?Thr?Ala?Gln?Ser?Glu?Ser?Val

325 330 335

His?Gly?Thr?Glu?Pro?Asp?Arg?Asp?Glu?Leu?Thr?Met?Phe?Tyr?Met?Trp

340 345 350

Leu?Gln?Trp?Leu?Cys?Asp?Glu?Gln?Leu?Ala?Ala?Ala?Gln?Lys?Arg?Ala

355 360 365

Val?Asp?Ala?Gly?Met?Ser?Ile?Gly?Ile?Met?Ala?Asp?Leu?Ala?Val?Gly

370 375 380

Val?His?Pro?Gly?Gly?Ala?Asp?Ala?Gln?Asn?Leu?Ser?His?Val?Leu?Ala

385 390 395 400

Pro?Asp?Ala?Ser?Val?Gly?Ala?Pro?Pro?Asp?Gly?Tyr?Asn?Gln?Gln?Gly

405 410 415

Gln?Asp?Trp?Ser?Gln?Pro?Pro?Trp?His?Pro?Val?Arg?Leu?Ala?Glu?Glu

420 425 430

Gly?Tyr?Ile?Pro?Trp?Arg?Asn?Leu?Leu?Arg?Thr?Val?Leu?Arg?His?Ser

435 440 445

Gly?Gly?Ile?Arg?Val?Asp?His?Val?Leu?Gly?Leu?Phe?Arg?Leu?Phe?Val

450 455 460

Met?Pro?Arg?Met?Gln?Ser?Pro?Ala?Thr?Gly?Thr?Tyr?Ile?Arg?Phe?Asp

465 470 475 480

His?Asn?Ala?Leu?Val?Gly?Ile?Leu?Ala?Leu?Glu?Ala?Glu?Leu?Ala?Gly

485 490 495

Ala?Val?Val?Ile?Gly?Glu?Asp?Leu?Gly?Thr?Phe?Glu?Pro?Trp?Val?Gln

500 505 510

Asp?Ala?Leu?Ala?Gln?Arg?Gly?Ile?Met?Gly?Thr?Ser?Ile?Leu?Trp?Phe

515 520 525

Glu?His?Ser?Pro?Ser?Gln?Pro?Gly?Pro?Arg?Arg?Gln?Glu?Glu?Tyr?Arg

530 535 540

Pro?Leu?Ala?Leu?Thr?Thr?Val?Thr?Thr?His?Asp?Leu?Pro?Pro?Thr?Ala

545 550 555 560

Gly?Tyr?Leu?Glu?Gly?Glu?His?Ile?Ala?Leu?Arg?Glu?Arg?Leu?Gly?Val

565 570 575

Leu?Asn?Thr?Asp?Pro?Ala?Ala?Glu?Leu?Ala?Glu?Asp?Leu?Gln?Trp?Gln

580 585 590

Ala?Glu?Ile?Leu?Asp?Val?Ala?Ala?Ser?Ala?Asn?Ala?Leu?Pro?Ala?Arg

595 600 605

Glu?Tyr?Val?Gly?Leu?Glu?Arg?Asp?Gln?Arg?Gly?Glu?Leu?Ala?Glu?Leu

610 615 620

Leu?Glu?Gly?Leu?His?Thr?Phe?Val?Ala?Lys?Thr?Pro?Ser?Ala?Leu?Thr

625 630 635 640

Cys?Val?Cys?Leu?Val?Asp?Met?Val?Gly?Glu?Lys?Arg?Ala?Gln?Asn?Gln

645 650 655

Pro?Gly?Thr?Thr?Arg?Asp?Met?Tyr?Pro?Asn?Trp?Cys?Ile?Pro?Leu?Cys

660 665 670

Asp?Ser?Glu?Gly?Asn?Ser?Val?Leu?Ile?Glu?Ser?Leu?Arg?Glu?Asn?Glu

675 680 685

Leu?Tyr?His?Arg?Val?Ala?Lys?Ala?Ser?Lys?Arg?Asp

690 695 700

<210>413

<211>1287

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1264)

<223>RXN00043

<400>413

aacagcaggc?ctcaagtccg?aagataatta?acctaaatcc?gtagacataa?gacatcatac?60

gtcctatgct?tgctggaagg?aagcaaataa?cctcagaaag?atg?gca?gaa?gtg?gtg 115

Met?Ala?Glu?Val?Val

1 5

cat?tat?caa?gaa?aat?gca?ggt?caa?gca?gtt?aaa?aaa?att?gaa?gga?aga 163

His?Tyr?Gln?Glu?Asn?Ala?Gly?Gln?Ala?Val?Lys?Lys?Ile?Glu?Gly?Arg

10 15 20

att?gtt?acc?ccc?cac?ggg?gtg?att?gat?ggc?ttt?ctc?caa?ctc?gaa?aac 211

Ile?Val?Thr?Pro?His?Gly?Val?Ile?Asp?Gly?Phe?Leu?Gln?Leu?Glu?Asn

25 30 35

ggc?atc?atc?acg?gaa?ctc?tct?gga?gaa?cca?gca?cct?aaa?aac?gca?gga 259

Gly?Ile?Ile?Thr?Glu?Leu?Ser?Gly?Glu?Pro?Ala?Pro?Lys?Asn?Ala?Gly

40 45 50

ttc?cac?ccc?gaa?ctc?ccc?acg?att?gtt?ccc?agt?ttt?att?gat?ctt?cat 307

Phe?His?Pro?Glu?Leu?Pro?Thr?Ile?Val?Pro?Ser?Phe?Ile?Asp?Leu?His

55 60 65

aat?cac?ggt?gga?aac?ggt?ggc?gcg?ttt?cct?acg?gga?acg?cag?gac?cag 355

Asn?His?Gly?Gly?Asn?Gly?Gly?Ala?Phe?Pro?Thr?Gly?Thr?Gln?Asp?Gln

70 75 80 85

gcg?agg?aat?gcc?gcg?cag?tat?cac?cgc?gaa?cat?ggc?acg?acc?gtg?atg 403

Ala?Arg?Asn?Ala?Ala?Gln?Tyr?His?Arg?Glu?His?Gly?Thr?Thr?Val?Met

90 95 100

ttg?gca?agc?atg?gtt?tcg?gcg?ccg?gct?gac?gca?ctg?gca?gcg?cag?gtg 451

Leu?Ala?Ser?Met?Val?Ser?Ala?Pro?Ala?Asp?Ala?Leu?Ala?Ala?Gln?Val

105 110 115

gaa?aac?ctt?att?ccc?ttg?tgt?gaa?gag?ggc?ctg?ctg?tgc?ggc?att?cac 499

Glu?Asn?Leu?Ile?Pro?Leu?Cys?Glu?Glu?Gly?Leu?Leu?Cys?Gly?Ile?His

120 125 130

ctc?gag?ggt?cct?ttc?atc?aac?gca?tgc?cgt?tgt?ggt?gct?caa?aac?ccg 547

Leu?Glu?Gly?Pro?Phe?Ile?Asn?Ala?Cys?Arg?Cys?Gly?Ala?Gln?Asn?Pro

135 140 145

gat?ttt?att?ttt?ccc?ggc?aac?cca?aca?gat?ctt?gcc?cag?gtg?atc?cat 595

Asp?Phe?Ile?Phe?Pro?Gly?Asn?Pro?Thr?Asp?Leu?Ala?Gln?Val?Ile?His

150 155 160 165

gcg?gga?aaa?ggt?tgg?atc?aaa?tcg?atc?aca?gta?gcg?ccg?gaa?act?gac 643

Ala?Gly?Lys?Gly?Trp?Ile?Lys?Ser?Ile?Thr?Val?Ala?Pro?Glu?Thr?Asp

170 175 180

aat?ctt?act?gag?ctt?ctc?gat?ctc?tgc?gca?gcg?cac?cac?atc?att?gct 691

Asn?Leu?Thr?Glu?Leu?Leu?Asp?Leu?Cys?Ala?Ala?His?His?Ile?Ile?Ala

185 190 195

tcc?ttc?ggg?cac?act?gat?gca?gat?ttt?gat?acc?act?acc?agc?gca?att 739

Ser?Phe?Gly?His?Thr?Asp?Ala?Asp?Phe?Asp?Thr?Thr?Thr?Ser?Ala?Ile

200 205 210

gcc?ttg?gct?aaa?gag?aaa?aat?gtg?acg?gtc?acg?gct?acg?cat?ttg?ttc 787

Ala?Leu?Ala?Lys?Glu?Lys?Asn?Val?Thr?Val?Thr?Ala?Thr?His?Leu?Phe

215 220 225

aat?gcg?atg?cct?ccg?ctg?cat?cat?agg?gat?ccc?ggc?agc?gtg?ggc?gct 835

Asn?Ala?Met?Pro?Pro?Leu?His?His?Arg?Asp?Pro?Gly?Ser?Val?Gly?Ala

230 235 240 245

ttg?ctt?gct?gcg?gca?cgt?gcc?ggg?gac?gca?tat?gtt?gag?ttg?atc?gcc 883

Leu?Leu?Ala?Ala?Ala?Arg?Ala?Gly?Asp?Ala?Tyr?Val?Glu?Leu?Ile?Ala

250 255 260

gac?ggc?gtg?cat?ttg?gcc?gat?gga?acg?gtc?gat?cta?gct?cgt?tcc?aac 931

Asp?Gly?Val?His?Leu?Ala?Asp?Gly?Thr?Val?Asp?Leu?Ala?Arg?Ser?Asn

265 270 275

aac?gcc?ttt?ttc?atc?acg?gac?gcc?atg?gaa?gcc?gcc?gga?atg?cca?gac 979

Asn?Ala?Phe?Phe?Ile?Thr?Asp?Ala?Met?Glu?Ala?Ala?Gly?Met?Pro?Asp

280 285 290

ggt?gag?tac?att?ttg?ggc?gtt?ttg?aac?gtc?acc?gtc?acc?gat?ggc?gtc 1027

Gly?Glu?Tyr?Ile?Leu?Gly?Val?Leu?Asn?Val?Thr?Val?Thr?Asp?Gly?Val

295 300 305

gcc?cgt?ctg?cgc?gat?ggc?ggc?gcc?atc?gcc?ggg?ggt?acc?agc?aca?cta 1075

Ala?Arg?Leu?Arg?Asp?Gly?Gly?Ala?Ile?Ala?Gly?Gly?Thr?Ser?Thr?Leu

310 315 320 325

gcg?agt?cag?ttc?gtg?cac?cac?gtg?cgc?agg?ggt?atg?acg?ctt?atc?gac 1123

Ala?Ser?Gln?Phe?Val?His?His?Val?Arg?Arg?Gly?Met?Thr?Leu?Ile?Asp

330 335 340

gcg?acc?ctc?cac?acc?tca?acc?gtc?gcc?gcc?aaa?att?ctc?gga?ctt?agc 1171

Ala?Thr?Leu?His?Thr?Ser?Thr?Val?Ala?Ala?Lys?Ile?Leu?Gly?Leu?Ser

345 350 355

gat?cac?gaa?atc?gtt?aaa?tcc?aac?cct?gta?aat?ttt?gtg?gtc?ttt?gac 1219

Asp?His?Glu?Ile?Val?Lys?Ser?Asn?Pro?Val?Asn?Phe?Val?Val?Phe?Asp

360 365 370

tca?aac?ggc?cag?tta?caa?cag?gtc?cat?tta?gac?cat?caa?gta?att 1264

Ser?Asn?Gly?Gln?Leu?Gln?Gln?Val?His?Leu?Asp?His?Gln?Val?Ile

375 380 385

taaatacgag?caaaactttc?ctg 1287

<210>414

<211>388

<212>PRT

＜213〉Corynebacterium glutamicum

<400>414

Met?Ala?Glu?Val?Val?His?Tyr?Gln?Glu?Asn?Ala?Gly?Gln?Ala?Val?Lys

1 5 10 15

Lys?Ile?Glu?Gly?Arg?Ile?Val?Thr?Pro?His?Gly?Val?Ile?Asp?Gly?Phe

20 25 30

Leu?Gln?Leu?Glu?Asn?Gly?Ile?Ile?Thr?Glu?Leu?Ser?Gly?Glu?Pro?Ala

35 40 45

Pro?Lys?Asn?Ala?Gly?Phe?His?Pro?Glu?Leu?Pro?Thr?Ile?Val?Pro?Ser

50 55 60

Phe?Ile?Asp?Leu?His?Asn?His?Gly?Gly?Asn?Gly?Gly?Ala?Phe?Pro?Thr

65 70 75 80

Gly?Thr?Gln?Asp?Gln?Ala?Arg?Asn?Ala?Ala?Gln?Tyr?His?Arg?Glu?His

85 90 95

Gly?Thr?Thr?Val?Met?Leu?Ala?Ser?Met?Val?Ser?Ala?Pro?Ala?Asp?Ala

100 105 110

Leu?Ala?Ala?Gln?Val?Glu?Asn?Leu?Ile?Pro?Leu?Cys?Glu?Glu?Gly?Leu

115 120 125

Leu?Cys?Gly?Ile?His?Leu?Glu?Gly?Pro?Phe?Ile?Asn?Ala?Cys?Arg?Cys

130 135 140

Gly?Ala?Gln?Asn?Pro?Asp?Phe?Ile?Phe?Pro?Gly?Asn?Pro?Thr?Asp?Leu

145 150 155 160

Ala?Gln?Val?Ile?His?Ala?Gly?Lys?Gly?Trp?Ile?Lys?Ser?Ile?Thr?Val

165 170 175

Ala?Pro?Glu?Thr?Asp?Asn?Leu?Thr?Glu?Leu?Leu?Asp?Leu?Cys?Ala?Ala

180 185 190

His?His?Ile?Ile?Ala?Ser?Phe?Gly?His?Thr?Asp?Ala?Asp?Phe?Asp?Thr

195 200 205

Thr?Thr?Ser?Ala?Ile?Ala?Leu?Ala?Lys?Glu?Lys?Asn?Val?Thr?Val?Thr

210 215 220

Ala?Thr?His?Leu?Phe?Asn?Ala?Met?Pro?Pro?Leu?His?His?Arg?Asp?Pro

225 230 235 240

Gly?Ser?Val?Gly?Ala?Leu?Leu?Ala?Ala?Ala?Arg?Ala?Gly?Asp?Ala?Tyr

245 250 255

Val?Glu?Leu?Ile?Ala?Asp?Gly?Val?His?Leu?Ala?Asp?Gly?Thr?Val?Asp

260 265 270

Leu?Ala?Arg?Ser?Asn?Asn?Ala?Phe?Phe?Ile?Thr?Asp?Ala?Met?Glu?Ala

275 280 285

Ala?Gly?Met?Pro?Asp?Gly?Glu?Tyr?Ile?Leu?Gly?Val?Leu?Asn?Val?Thr

290 295 300

Val?Thr?Asp?Gly?Val?Ala?Arg?Leu?Arg?Asp?Gly?Gly?Ala?Ile?Ala?Gly

305 310 315 320

Gly?Thr?Ser?Thr?Leu?Ala?Ser?Gln?Phe?Val?His?His?Val?Arg?Arg?Gly

325 330 335

Met?Thr?Leu?Ile?Asp?Ala?Thr?Leu?His?Thr?Ser?Thr?Val?Ala?Ala?Lys

340 345 350

Ile?Leu?Gly?Leu?Ser?Asp?His?Glu?Ile?Val?Lys?Ser?Asn?Pro?Val?Asn

355 360 365

Phe?Val?Val?Phe?Asp?Ser?Asn?Gly?Gln?Leu?Gln?Gln?Val?His?Leu?Asp

370 375 380

His?Gln?Val?Ile

385

<210>415

<211>1287

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1264)

<223>FRXA00043

<400>415

aacagcaggc?ctcaagtccg?aagataatta?acctaaatcc?gtagacataa?gacatcatac?60

gtcctatgct?tgctggaagg?aagcaaataa?cctcagaaag?atg?gca?gaa?gtg?gtg 115

Met?Ala?Glu?Val?Val

1 5

cat?tat?caa?gaa?aat?gca?ggt?caa?gca?gtt?aaa?aaa?att?gaa?gga?aga 163

His?Tyr?Gln?Glu?Asn?Ala?Gly?Gln?Ala?Val?Lys?Lys?Ile?Glu?Gly?Arg

10 15 20

att?gtt?acc?ccc?cac?ggg?gtg?att?gat?ggc?ttt?ctc?caa?ctc?gaa?aac 211

Ile?Val?Thr?Pro?His?GlyVal?Ile?Asp?Gly?Phe?Leu?Gln?Leu?Glu?Asn

25 30 35

ggc?atc?atc?acg?gaa?ctc?tct?gga?gaa?cca?gca?cct?aaa?aac?gca?gga 259

Gly?Ile?Ile?Thr?Glu?Leu?Ser?Gly?Glu?Pro?Ala?Pro?Lys?Asn?Ala?Gly

40 45 50

ttc?cac?ccc?gaa?ctc?ccc?acg?att?gtt?ccc?agt?ttt?att?gat?ctt?cat 307

Phe?His?Pro?Glu?Leu?Pro?Thr?Ile?Val?Pro?Ser?Phe?Ile?Asp?Leu?His

55 60 65

aat?cac?ggt?gga?aac?ggt?ggc?gcg?ttt?cct?acg?gga?acg?cag?gac?cag 355

Asn?His?Gly?Gly?Asn?Gly?Gly?Ala?Phe?Pro?Thr?Gly?Thr?Gln?Asp?Gln

70 75 80 85

gcg?agg?aat?gcc?gcg?cag?tat?cac?cgc?gaa?cat?ggc?acg?acc?gtg?atg 403

Ala?Arg?Asn?Ala?Ala?Gln?Tyr?His?Arg?Glu?His?Gly?Thr?Thr?Val?Met

90 95 100

ttg?gca?agc?atg?gtt?tcg?gcg?ccg?gct?gac?gca?ctg?gca?gcg?cag?gtg 451

Leu?Ala?Ser?Met?Val?Ser?Ala?Pro?Ala?Asp?Ala?Leu?Ala?Ala?Gln?Val

105 110 115

gaa?aac?ctt?att?ccc?ttg?tgt?gaa?gag?ggc?ctg?ctg?tgc?ggc?att?cac 499

Glu?Asn?Leu?Ile?Pro?Leu?Cys?Glu?Glu?Gly?Leu?Leu?Cys?Gly?Ile?His

120 125 130

ctc?gag?ggt?cct?ttc?atc?aac?gca?tgc?cgt?tgt?ggt?gct?caa?aac?ccg 547

Leu?Glu?Gly?Pro?Phe?Ile?Asn?Ala?Cys?Arg?Cys?Gly?Ala?Gln?Asn?Pro

135 140 145

gat?ttt?att?ttt?ccc?ggc?aac?cca?aca?gat?ctt?gcc?cag?gtg?atc?cat 595

Asp?Phe?Ile?Phe?Pro?Gly?Asn?Pro?Thr?Asp?Leu?Ala?Gln?Val?Ile?His

150 155 160 165

gcg?gga?aaa?ggt?tgg?atc?aaa?tcg?atc?aca?gta?gcg?ccg?gaa?act?gac 643

Ala?Gly?Lys?Gly?Trp?Ile?Lys?Ser?Ile?Thr?Val?Ala?Pro?Glu?Thr?Asp

170 175 180

aat?ctt?act?gag?ctt?ctc?gat?ctc?tgc?gca?gcg?cac?cac?atc?att?gct 691

Asn?Leu?Thr?Glu?Leu?Leu?Asp?Leu?Cys?Ala?Ala?His?His?Ile?Ile?Ala

185 190 195

tcc?ttc?ggg?cac?act?gat?gca?gat?ttt?gat?acc?act?acc?agc?gca?att 739

Ser?Phe?Gly?His?Thr?Asp?Ala?Asp?Phe?Asp?Thr?Thr?Thr?Ser?Ala?Ile

200 205 210

gcc?ttg?gct?aaa?gag?aaa?aat?gtg?acg?gtc?acg?gct?acg?cat?ttg?ttc 787

Ala?Leu?Ala?Lys?Glu?Lys?Asn?Val?Thr?Val?Thr?Ala?Thr?His?Leu?Phe

215 220 225

aat?gcg?atg?cct?ccg?ctg?cat?cat?agg?gat?ccc?ggc?agc?gtg?ggc?gct 835

Asn?Ala?Met?Pro?Pro?Leu?His?His?Arg?Asp?Pro?Gly?Ser?Val?Gly?Ala

230 235 240 245

ttg?ctt?gct?gcg?gca?cgt?gcc?ggg?gac?gca?tat?gtt?gag?ttg?atc?gcc 883

Leu?Leu?Ala?Ala?Ala?Arg?Ala?Gly?Asp?Ala?Tyr?Val?Glu?Leu?Ile?Ala

250 255 260

gac?ggc?gtg?cat?ttg?gcc?gat?gga?acg?gtc?gat?cta?gct?cgt?tcc?aac 931

Asp?Gly?Val?His?Leu?Ala?Asp?Gly?Thr?Val?Asp?Leu?Ala?Arg?Ser?Asn

265 270 275

aac?gcc?ttt?ttc?atc?acg?gac?gcc?atg?gaa?gcc?gcc?gga?atg?cca?gac 979

Asn?Ala?Phe?Phe?Ile?Thr?Asp?Ala?Met?Glu?Ala?Ala?Gly?Met?Pro?Asp

280 285 290

ggt?gag?tac?att?ttg?ggc?gtt?ttg?aac?gtc?acc?gtc?acc?gat?ggc?gtc 1027

Gly?Glu?Tyr?Ile?Leu?Gly?Val?Leu?Asn?Val?Thr?Val?Thr?Asp?Gly?Val

295 300 305

gcc?cgt?ctg?cgc?gat?ggc?ggc?gcc?atc?gcc?ggg?ggt?acc?agc?aca?cta 1075

Ala?Arg?Leu?Arg?Asp?Gly?Gly?Ala?Ile?Ala?Gly?Gly?Thr?Ser?Thr?Leu

310 315 320 325

gcg?agt?cag?ttc?gtg?cac?cac?gtg?cgc?agg?ggt?atg?acg?ctt?atc?gac 1123

Ala?Ser?Gln?Phe?Val?His?His?Val?Arg?Arg?Gly?Met?Thr?Leu?Ile?Asp

330 335 340

gcg?acc?ctc?cac?acc?tca?acc?gtc?gcc?gcc?aaa?att?ctc?gga?ctt?agc 1171

Ala?Thr?Leu?His?Thr?Ser?Thr?Val?Ala?Ala?Lys?Ile?Leu?Gly?Leu?Ser

345 350 355

gat?cac?gaa?atc?gtt?aaa?tcc?aac?cct?gta?aat?ttt?gtg?gtc?ttt?gac 1219

Asp?His?Glu?Ile?Val?Lys?Ser?Asn?Pro?Val?Asn?Phe?Val?Val?Phe?Asp

360 365 370

tca?aac?ggc?cag?tta?caa?cag?gtc?cat?tta?gac?cat?caa?gta?att 1264

Ser?Asn?Gly?Gln?Leu?Gln?Gln?Val?His?Leu?Asp?His?Gln?Val?Ile

375 380 385

taaatacgag?caaaactttc?ctg 1287

<210>416

<211>388

<212>PRT

＜213〉Corynebacterium glutamicum

<400>416

Met?Ala?Glu?Val?Val?His?Tyr?Gln?Glu?Asn?Ala?Gly?Gln?Ala?Val?Lys

1 5 10 15

Lys?Ile?Glu?Gly?Arg?Ile?Val?Thr?Pro?His?Gly?Val?Ile?Asp?Gly?Phe

20 25 30

Leu?Gln?Leu?Glu?Asn?Gly?Ile?Ile?Thr?Glu?Leu?Ser?Gly?Glu?Pro?Ala

35 40 45

Pro?Lys?Asn?Ala?Gly?Phe?His?Pro?Glu?Leu?Pro?Thr?Ile?Val?Pro?Ser

50 55 60

Phe?Ile?Asp?Leu?His?Asn?His?Gly?Gly?Asn?Gly?Gly?Ala?Phe?Pro?Thr

65 70 75 80

Gly?Thr?Gln?Asp?Gln?Ala?Arg?Asn?Ala?Ala?Gln?Tyr?His?Arg?Glu?His

85 90 95

Gly?Thr?Thr?Val?Met?Leu?Ala?Ser?Met?Val?Ser?Ala?Pro?Ala?Asp?Ala

100 105 110

Leu?Ala?Ala?Gln?Val?Glu?Asn?Leu?Ile?Pro?Leu?Cys?Glu?Glu?Gly?Leu

115 120 125

Leu?Cys?Gly?Ile?His?Leu?Glu?Gly?Pro?Phe?Ile?Asn?Ala?Cys?Arg?Cys

130 135 140

Gly?Ala?Gln?Asn?Pro?Asp?Phe?Ile?Phe?Pro?Gly?Asn?Pro?Thr?Asp?Leu

145 150 155 160

Ala?Gln?Val?Ile?His?Ala?Gly?Lys?Gly?Trp?Ile?Lys?Ser?Ile?Thr?Val

165 170 175

Ala?Pro?Glu?Thr?Asp?Asn?Leu?Thr?Glu?Leu?Leu?Asp?Leu?Cys?Ala?Ala

180 185 190

His?His?Ile?Ile?Ala?Ser?Phe?Gly?His?Thr?Asp?Ala?Asp?Phe?Asp?Thr

195 200 205

Thr?Thr?Ser?Ala?Ile?Ala?Leu?Ala?Lys?Glu?Lys?Asn?Val?Thr?Val?Thr

210 215 220

Ala?Thr?His?Leu?Phe?Asn?Ala?Met?Pro?Pro?Leu?His?His?Arg?Asp?Pro

225 230 235 240

Gly?Ser?Val?Gly?Ala?Leu?Leu?Ala?Ala?Ala?Arg?Ala?Gly?Asp?Ala?Tyr

245 250 255

Val?Glu?Leu?Ile?Ala?Asp?Gly?Val?His?Leu?Ala?Asp?Gly?Thr?Val?Asp

260 265 270

Leu?Ala?Arg?Ser?Asn?Asn?Ala?Phe?Phe?Ile?Thr?Asp?Ala?Met?Glu?Ala

275 280 285

Ala?Gly?Met?Pro?Asp?Gly?Glu?Tyr?Ile?Leu?Gly?Val?Leu?Asn?Val?Thr

290 295 300

Val?Thr?Asp?Gly?Val?Ala?Arg?Leu?Arg?Asp?Gly?Gly?Ala?Ile?Ala?Gly

305 310 315 320

Gly?Thr?Ser?Thr?Leu?Ala?Ser?Gln?Phe?Val?His?His?Val?Arg?Arg?Gly

325 330 335

Met?Thr?Leu?Ile?Asp?Ala?Thr?Leu?His?Thr?Ser?Thr?Val?Ala?Ala?Lys

340 345 350

Ile?Leu?Gly?Leu?Ser?Asp?His?Glu?Ile?Val?Lys?Ser?Asn?Pro?Val?Asn

355 360 365

Phe?Val?Val?Phe?Asp?Ser?Asn?Gly?Gln?Leu?Gln?Gln?Val?His?Leu?Asp

370 375 380

His?Gln?Val?Ile

385

<210>417

<211>1584

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1561)

<223>RXN01752

<400>417

gaaatgacgt?gaccatcgat?accaataccc?aattgaaaga?tcttgacctg?gtcagccaag?60

ttggccgtca?gatcgtggca?gaacaacagg?tggggaggtc?atg?atg?gaa?caa?gat 115

Met?Met?Glu?Gln?Asp

1 5

ctc?agc?tac?cgt?gaa?att?ctt?ccc?ctc?aac?gcg?agt?gag?gag?aag?aaa 163

Leu?Ser?Tyr?Arg?Glu?Ile?Leu?Pro?Leu?Asn?Ala?Ser?Glu?Glu?Lys?Lys

10 15 20

aag?gct?gca?ctg?att?gat?gcc?att?gaa?ggg?tta?agg?gtg?cgc?gat?ccg 211

Lys?Ala?Ala?Leu?Ile?Asp?Ala?Ile?Glu?Gly?Leu?Arg?Val?Arg?Asp?Pro

25 30 35

cta?ctc?tct?gcc?tcg?att?gca?ttt?act?aga?ggg?cag?aaa?gtc?gcc?ttc 259

Leu?Leu?Ser?Ala?Ser?Ile?Ala?Phe?Thr?Arg?Gly?Gln?Lys?Val?Ala?Phe

40 45 50

att?gct?gtg?gtg?gtg?ggc?ttt?atc?ttg?atg?ctc?att?ttt?gct?cgg?caa 307

Ile?Ala?Val?Val?Val?Gly?Phe?Ile?Leu?Met?Leu?Ile?Phe?Ala?Arg?Gln

55 60 65

gca?gca?ctt?att?gga?ctg?tca?gca?acg?tgt?acg?ttc?atg?tac?ctc?att 355

Ala?Ala?Leu?Ile?Gly?Leu?Ser?Ala?Thr?Cys?Thr?Phe?Met?Tyr?Leu?Ile

70 75 80 85

aca?ttg?ttg?gac?aga?ttt?atc?atg?ttt?tcc?aga?ggt?atc?cgc?gcg?gaa 403

Thr?Leu?Leu?Asp?Arg?Phe?Ile?Met?Phe?Ser?Arg?Gly?Ile?Arg?Ala?Glu

90 95 100

tcc?atc?atc?cag?gta?tcg?gat?gaa?gat?gcg?ctg?gct?ttc?cct?gag?gac 451

Ser?Ile?Ile?Gln?Val?Ser?Asp?Glu?Asp?Ala?Leu?Ala?Phe?Pro?Glu?Asp

105 110 115

aag?ctg?aaa?acc?tac?acg?gtg?ttg?gtg?ccc?gcc?tat?ggc?gaa?cct?gag 499

Lys?Leu?Lys?Thr?Tyr?Thr?Val?Leu?Val?Pro?Ala?Tyr?Gly?Glu?Pro?Glu

120 125 130

gtg?att?gcg?cag?ctg?ctg?gca?tcc?atg?cac?gct?ttt?gat?tac?ccc?aag 547

Val?Ile?Ala?Gln?Leu?Leu?Ala?Ser?Met?His?Ala?Phe?Asp?Tyr?Pro?Lys

135 140 145

cat?ctt?ctg?cag?gta?ttg?ctc?atg?ttg?gag?gaa?gat?gat?ctg?ccc?acg 595

His?Leu?Leu?Gln?Val?Leu?Leu?Met?Leu?Glu?Glu?Asp?Asp?Leu?Pro?Thr

150 155 160 165

atc?gcc?gcg?gca?gag?gca?gcg?gga?gtg?gat?cag?gtg?gca?acg?atc?att 643

Ile?Ala?Ala?Ala?Glu?Ala?Ala?Gly?Val?Asp?Gln?Val?Ala?Thr?Ile?Ile

170 175 180

aag?gtg?ccg?cca?gcg?cag?ccc?cgc?acc?aag?ccg?aag?gcc?tgt?aac?tat 691

Lys?Val?Pro?Pro?Ala?Gln?Pro?Arg?Thr?Lys?Pro?Lys?Ala?Cys?Asn?Tyr

185 190 195

gga?ttg?cac?ttt?gcc?acg?ggg?gaa?att?gtc?acg?atc?ttt?gac?gcg?gaa 739

Gly?Leu?His?Phe?Ala?Thr?Gly?Glu?Ile?Val?Thr?Ile?Phe?Asp?Ala?Glu

200 205 210

gac?atg?cca?gat?ccc?ctc?caa?ctg?cgt?cgc?gtg?gtg?gtg?gca?ttt?gaa 787

Asp?Met?Pro?Asp?Pro?Leu?Gln?Leu?Arg?Arg?Val?Val?Val?Ala?Phe?Glu

215 220 225

cgc?tcg?gct?tcc?aat?acg?gtg?tgc?gtc?cag?tca?agg?ttg?tcg?tat?cga 835

Arg?Ser?Ala?Ser?Asn?Thr?Val?Cys?Val?Gln?Ser?Arg?Leu?Ser?Tyr?Arg

230 235 240 245

aac?gcc?agg?cag?aat?ctg?cta?act?gcg?tgg?ttc?acc?att?gaa?tat?gac 883

Asn?Ala?Arg?Gln?Asn?Leu?Leu?Thr?Ala?Trp?Phe?Thr?Ile?Glu?Tyr?Asp

250 255 260

gtg?tgg?ttt?aac?ttc?ctg?ctg?cca?ggc?gtc?atg?cgc?atg?aac?gca?cct 931

Val?Trp?Phe?Asn?Phe?Leu?Leu?Pro?Gly?Val?Met?Arg?Met?Asn?Ala?Pro

265 270 275

gtc?cca?ttg?ggc?ggt?acc?tcc?aac?cat?ctg?ctc?acg?ggt?gtc?ctg?aaa 979

Val?Pro?Leu?Gly?Gly?Thr?Ser?Asn?His?Leu?Leu?Thr?Gly?Val?Leu?Lys

280 285 290

gat?ctc?ggc?gcg?tgg?gat?cct?ttc?aat?gtc?aca?gaa?aat?gcc?gac?ctc 1027

Asp?Leu?Gly?Ala?Trp?Asp?Pro?Phe?Asn?Val?Thr?Glu?Asn?Ala?Asp?Leu

295 300 305

ggc?gta?ccc?atc?gcg?gca?aaa?gga?tat?tcc?acc?gcg?gtg?ttg?gat?tcg 1075

Gly?Val?Pro?Ile?Ala?Ala?Lys?Gly?Tyr?Ser?Thr?Ala?Val?Leu?Asp?Ser

310 315 320 325

gtg?acg?tgg?gag?gaa?gca?aac?tcc?gac?acc?atc?aac?tgg?ttg?cgc?cag 1123

Val?Thr?Trp?Glu?Glu?Ala?Asn?Ser?Asp?Thr?Ile?Asn?Trp?Leu?Arg?Gln

330 335 340

cgt?tct?cgc?tgg?tac?aag?ggc?tat?ctg?caa?aca?tgg?ctt?gtg?tat?atg 1171

Arg?Ser?Arg?Trp?Tyr?Lys?Gly?Tyr?Leu?Gln?Thr?Trp?Leu?Val?Tyr?Met

345 350 355

cgc?agg?cca?aag?tgg?tta?gtc?caa?gag?ctt?ggc?atc?att?cct?gct?gtg 1219

Arg?Arg?Pro?Lys?Trp?Leu?Val?Gln?Glu?Leu?Gly?Ile?Ile?Pro?Ala?Val

360 365 370

cgt?ttt?acc?ttc?ctc?atg?gca?ggc?acc?ccg?atc?att?gcg?gtg?ctc?aat 1267

Arg?Phe?Thr?Phe?Leu?Met?Ala?Gly?Thr?Pro?Ile?Ile?Ala?Val?Leu?Asn

375 380 385

ctg?ctc?ttt?tgg?tac?ttg?tcg?ctc?acg?tgg?att?ctg?ggc?cag?ccc?ggc 1315

Leu?Leu?Phe?Trp?Tyr?Leu?Ser?Leu?Thr?Trp?Ile?Leu?Gly?Gln?Pro?Gly

390 395 400 405

acc?att?gag?cag?atg?ttc?cca?cct?gcg?gtg?tac?tac?cca?gcg?ttg?gtg 1363

Thr?Ile?Glu?Gln?Met?Phe?Pro?Pro?Ala?Val?Tyr?Tyr?Pro?Ala?Leu?Val

410 415 420

tgt?ttg?gtg?gtg?gcc?aat?gct?gcg?acc?atc?ttt?atg?aat?ctc?att?ggc 1411

Cys?Leu?Val?Val?Ala?Asn?Ala?Ala?Thr?Ile?Phe?Met?Asn?Leu?Ile?Gly

425 430 435

tgc?cgg?gaa?ggc?cgc?gac?ccc?ttg?ctg?ctc?atc?gcg?gtt?ctc?acg?ttc 1459

Cys?Arg?Glu?Gly?Arg?Asp?Pro?Leu?Leu?Leu?Ile?Ala?Val?Leu?Thr?Phe

440 445 450

ccg?ctg?tat?tgg?ctg?ctc?atg?agc?att?gca?gcg?ttg?aaa?ggc?acg?tgg 1507

Pro?Leu?Tyr?Trp?Leu?Leu?Met?Ser?Ile?Ala?Ala?Leu?Lys?Gly?Thr?Trp

455 460 465

caa?ttg?atc?acg?cga?cca?tcc?tat?tgg?gag?aaa?act?gcc?cac?gga?ttg 1555

Gln?Leu?Ile?Thr?Arg?Pro?Ser?Tyr?Trp?Glu?Lys?Thr?Ala?His?Gly?Leu

470 475 480 485

gag?gcg?taagcggtgc?ccatcgtcaa?acc 1584

Glu?Ala

<210>418

<211>487

<212>PRT

＜213〉Corynebacterium glutamicum

<400>418

Met?Met?Glu?Gln?Asp?Leu?Ser?Tyr?Arg?Glu?Ile?Leu?Pro?Leu?Asn?Ala

1 5 10 15

Ser?Glu?Glu?Lys?Lys?Lys?Ala?Ala?Leu?Ile?Asp?Ala?Ile?Glu?Gly?Leu

20 25 30

Arg?Val?Arg?Asp?Pro?Leu?Leu?Ser?Ala?Ser?Ile?Ala?Phe?Thr?Arg?Gly

35 40 45

Gln?Lys?Val?Ala?Phe?Ile?Ala?Val?Val?Val?Gly?Phe?Ile?Leu?Met?Leu

50 55 60

Ile?Phe?Ala?Arg?Gln?Ala?Ala?Leu?Ile?Gly?Leu?Ser?Ala?Thr?Cys?Thr

65 70 75 80

Phe?Met?Tyr?Leu?Ile?Thr?Leu?Leu?Asp?Arg?Phe?Ile?Met?Phe?Ser?Arg

85 90 95

Gly?Ile?Arg?Ala?Glu?Ser?Ile?Ile?Gln?Val?Ser?Asp?Glu?Asp?Ala?Leu

100 105 110

Ala?Phe?Pro?Glu?Asp?Lys?Leu?Lys?Thr?Tyr?Thr?Val?Leu?Val?Pro?Ala

115 120 125

Tyr?Gly?Glu?Pro?Glu?Val?Ile?Ala?Gln?Leu?Leu?Ala?Ser?Met?His?Ala

130 135 140

Phe?Asp?Tyr?Pro?Lys?His?Leu?Leu?Gln?Val?Leu?Leu?Met?Leu?Glu?Glu

145 150 155 160

Asp?Asp?Leu?Pro?Thr?Ile?Ala?Ala?Ala?Glu?Ala?Ala?Gly?Val?Asp?Gln

165 170 175

Val?Ala?Thr?Ile?Ile?Lys?Val?Pro?Pro?Ala?Gln?Pro?Arg?Thr?Lys?Pro

180 185 190

Lys?Ala?Cys?Asn?Tyr?Gly?Leu?His?Phe?Ala?Thr?Gly?Glu?Ile?Val?Thr

195 200 205

Ile?Phe?Asp?Ala?Glu?Asp?Met?Pro?Asp?Pro?Leu?Gln?Leu?Arg?Arg?Val

210 215 220

Val?Val?Ala?Phe?Glu?Arg?Ser?Ala?Ser?Asn?Thr?Val?Cys?Val?Gln?Ser

225 230 235 240

Arg?Leu?Ser?Tyr?Arg?Asn?Ala?Arg?Gln?Asn?Leu?Leu?Thr?Ala?Trp?Phe

245 250 255

Thr?Ile?Glu?Tyr?Asp?Val?Trp?Phe?Asn?Phe?Leu?Leu?Pro?Gly?Val?Met

260 265 270

Arg?Met?Asn?Ala?Pro?Val?Pro?Leu?Gly?Gly?Thr?Ser?Asn?His?Leu?Leu

275 280 285

Thr?Gly?Val?Leu?Lys?Asp?Leu?Gly?Ala?Trp?Asp?Pro?Phe?Asn?Val?Thr

290 295 300

Glu?Asn?Ala?Asp?Leu?Gly?Val?Pro?Ile?Ala?Ala?Lys?Gly?Tyr?Ser?Thr

305 310 315 320

Ala?Val?Leu?Asp?Ser?Val?Thr?Trp?Glu?Glu?Ala?Asn?Ser?Asp?Thr?Ile

325 330 335

Asn?Trp?Leu?Arg?Gln?Arg?Ser?Arg?Trp?Tyr?Lys?Gly?Tyr?Leu?Gln?Thr

340 345 350

Trp?Leu?Val?Tyr?Met?Arg?Arg?Pro?Lys?Trp?Leu?Val?Gln?Glu?Leu?Gly

355 360 365

Ile?Ile?Pro?Ala?Val?Arg?Phe?Thr?Phe?Leu?Met?Ala?Gly?Thr?Pro?Ile

370 375 380

Ile?Ala?Val?Leu?Asn?Leu?Leu?Phe?Trp?Tyr?Leu?Ser?Leu?Thr?Trp?Ile

385 390 395 400

Leu?Gly?Gln?Pro?Gly?Thr?Ile?Glu?Gln?Met?Phe?Pro?Pro?Ala?Val?Tyr

405 410 415

Tyr?Pro?Ala?Leu?Val?Cys?Leu?Val?Val?Ala?Asn?Ala?Ala?Thr?Ile?Phe

420 425 430

Met?Asn?Leu?Ile?Gly?Cys?Arg?Glu?Gly?Arg?Asp?Pro?Leu?Leu?Leu?Ile

435 440 445

Ala?Val?Leu?Thr?Phe?Pro?Leu?Tyr?Trp?Leu?Leu?Met?Ser?Ile?Ala?Ala

450 455 460

Leu?Lys?Gly?Thr?Trp?Gln?Leu?Ile?Thr?Arg?Pro?Ser?Tyr?Trp?Glu?Lys

465 470 475 480

Thr?Ala?His?Gly?Leu?Glu?Ala

485

<210>419

<211>689

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(19)..(666)

<223>FRXA01839

<400>419

ttcctgctgc?caggtgtc?atg?cgc?atg?aac?gca?cct?gtc?cca?ttg?ggc?ggt 51

Met?Arg?Met?Asn?Ala?Pro?Val?Pro?Leu?Gly?Gly

1 5 10

acc?tcc?aac?cat?ctg?ctc?acg?ggt?gtc?ctg?aaa?gat?ctc?ggc?gcg?tgg 99

Thr?Ser?Asn?His?Leu?Leu?Thr?Gly?Val?Leu?Lys?Asp?Leu?Gly?Ala?Trp

15 20 25

gat?cct?ttc?aat?gtc?aca?gaa?gat?gcg?gac?ctc?ggc?gta?cgc?atc?gcg 147

Asp?Pro?Phe?Asn?Val?Thr?Glu?Asp?Ala?Asp?Leu?Gly?Val?Arg?Ile?Ala

30 35 40

gca?aag?gga?tat?tcc?acc?gcg?gtg?ttg?gat?tcg?gtg?acg?tgg?gag?gaa 195

Ala?Lys?Gly?Tyr?Ser?Thr?Ala?Val?Leu?Asp?Ser?Val?Thr?Trp?Glu?Glu

45 50 55

gca?aac?tcc?gac?acc?atc?aac?tgg?ttg?cgc?cag?cgt?tct?cgc?tgg?tac 243

Ala?Asn?Ser?Asp?Thr?Ile?Asn?Trp?Leu?Arg?Gln?Arg?Ser?Arg?Trp?Tyr

60 65 70 75

aag?ggc?tat?ctg?caa?aca?tgg?ctt?gtg?tat?atg?cgc?agg?cca?aag?tgg 291

Lys?Gly?Tyr?Leu?Gln?Thr?Trp?Leu?Val?Tyr?Met?Arg?Arg?Pro?Lys?Trp

80 85 90

tta?gtc?caa?gag?ctt?ggc?atc?att?cct?gct?gtg?cgt?ttt?acc?ttc?ctc 339

Leu?Val?Gln?Glu?Leu?Gly?Ile?Ile?Pro?Ala?Val?Arg?Phe?Thr?Phe?Leu

95 100 105

atg?gca?ggc?acc?ccg?atc?att?gcg?gtg?ctc?aat?ctg?ctc?ttt?tgg?tac 387

Met?Ala?Gly?Thr?Pro?Ile?Ile?Ala?Val?Leu?Asn?Leu?Leu?Phe?Trp?Tyr

110 115 120

ttg?tcg?ctc?acg?tgg?att?ctg?ggc?cag?ccc?ggc?acc?att?gag?cag?atg 435

Leu?Ser?Leu?Thr?Trp?Ile?Leu?Gly?Gln?Pro?Gly?Thr?Ile?Glu?Gln?Met

125 130 135

ttc?cca?cct?gcg?gtg?tac?tac?cca?gcg?ttg?gtg?tgt?ttg?gtg?gtg?gcc 483

Phe?Pro?Pro?Ala?Val?Tyr?Tyr?Pro?Ala?Leu?Val?Cys?Leu?Val?Val?Ala

140 145 150 155

aat?gct?gcg?acc?atc?ttt?atg?aat?ctc?att?ggc?tgc?cgg?gaa?ggc?cgc 531

Asn?Ala?Ala?Thr?Ile?Phe?Met?Asn?Leu?Ile?Gly?Cys?Arg?Glu?Gly?Arg

160 165 170

gac?ccc?ttg?ctg?ctc?atc?gcg?gtt?ctc?acg?ttc?ccg?ctg?tat?tgg?ctg 579

Asp?Pro?Leu?Leu?Leu?Ile?Ala?Val?Leu?Thr?Phe?Pro?Leu?Tyr?Trp?Leu

175 180 185

ctc?atg?agc?att?gca?gcg?ttg?aaa?ggc?acg?tgg?caa?ttg?atc?acg?cga 627

Leu?Met?Ser?Ile?Ala?Ala?Leu?Lys?Gly?Thr?Trp?Gln?Leu?Ile?Thr?Arg

190 195 200

cca?tcc?tat?tgg?gag?aaa?act?gcc?cac?gga?ttg?gag?gcg?taagcggtgc 676

Pro?Ser?Tyr?Trp?Glu?Lys?Thr?Ala?His?Gly?Leu?Glu?Ala

205 210 215

ccatcgtcaa?acc 689

<210>420

<211>216

<212>PRT

＜213〉Corynebacterium glutamicum

<400>420

Met?Arg?Met?Asn?Ala?Pro?Val?Pro?Leu?Gly?Gly?Thr?Ser?Asn?His?Leu

1 5 10 15

Leu?Thr?Gly?Val?Leu?Lys?Asp?Leu?Gly?Ala?Trp?Asp?Pro?Phe?Asn?Val

20 25 30

Thr?Glu?Asp?Ala?Asp?Leu?Gly?Val?Arg?Ile?Ala?Ala?Lys?Gly?Tyr?Ser

35 40 45

Thr?Ala?Val?Leu?Asp?Ser?Val?Thr?Trp?Glu?Glu?Ala?Asn?Ser?Asp?Thr

50 55 60

Ile?Asn?Trp?Leu?Arg?Gln?Arg?Ser?Arg?Trp?Tyr?Lys?Gly?Tyr?Leu?Gln

65 70 75 80

Thr?Trp?Leu?Val?Tyr?Met?Arg?Arg?Pro?Lys?Trp?Leu?Val?Gln?Glu?Leu

85 90 95

Gly?Ile?Ile?Pro?Ala?Val?Arg?Phe?Thr?Phe?Leu?Met?Ala?Gly?Thr?Pro

100 105 110

Ile?Ile?Ala?Val?Leu?Asn?Leu?Leu?Phe?Trp?Tyr?Leu?Ser?Leu?Thr?Trp

115 120 125

Ile?Leu?Gly?Gln?Pro?Gly?Thr?Ile?Glu?Gln?Met?Phe?Pro?Pro?Ala?Val

130 135 140

Tyr?Tyr?Pro?Ala?Leu?Val?Cys?Leu?Val?Val?Ala?Asn?Ala?Ala?Thr?Ile

145 150 155 160

Phe?Met?Asn?Leu?Ile?Gly?Cys?Arg?Glu?Gly?Arg?Asp?Pro?Leu?Leu?Leu

165 170 175

Ile?Ala?Val?Leu?Thr?Phe?Pro?Leu?Tyr?Trp?Leu?Leu?Met?Ser?Ile?Ala

180 185 190

Ala?Leu?Lys?Gly?Thr?Trp?Gln?Leu?Ile?Thr?Arg?Pro?Ser?Tyr?Trp?Glu

195 200 205

Lys?Thr?Ala?His?Gly?Leu?Glu?Ala

210 215

<210>421

<211>1050

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1027)

<223>RXA01859

<400>421

tacgcccagg?gtttccatat?tggtaaatct?aagccgattg?atgaatttat?agctacttat?60

ctcgagacga?accaaaccgc?tacctggggg?taggaagaat?atg?aaa?aag?aag?agc 115

Met?Lys?Lys?Lys?Ser

1 5

ttt?cca?atc?gca?aga?gtc?atc?ggt?atc?ggc?gtc?ctt?ggc?atc?gcc?ggg 163

Phe?Pro?Ile?Ala?Arg?Val?Ile?Gly?Ile?Gly?Val?Leu?Gly?Ile?Ala?Gly

10 15 20

atg?gga?ata?ttg?ttg?cta?tgg?ctt?gca?gtt?acc?ctg?tct?gat?cca?gca 211

Met?Gly?Ile?Leu?Leu?Leu?Trp?Leu?Ala?Val?Thr?Leu?Ser?Asp?Pro?Ala

25 30 35

tca?ccg?ggt?gcc?aaa?gaa?acc?gaa?gtc?ttt?gat?agg?tgg?aaa?gtg?ctc 259

Ser?Pro?Gly?Ala?Lys?Glu?Thr?Glu?Val?Phe?Asp?Arg?Trp?Lys?Val?Leu

40 45 50

ttt?gat?gac?tat?att?cca?cca?gtc?agg?gta?ttg?gtt?gct?gcg?att?atc 307

Phe?Asp?Asp?Tyr?Ile?Pro?Pro?Val?Arg?Val?Leu?Val?Ala?Ala?Ile?Ile

55 60 65

gtt?gca?tta?att?ttc?gtc?ttt?atc?gct?gcc?aca?gtg?gaa?cga?acc?gta 355

Val?Ala?Leu?Ile?Phe?Val?Phe?Ile?Ala?Ala?Thr?Val?Glu?Arg?Thr?Val

70 75 80 85

acc?aac?cgc?tac?cga?agc?tcc?gta?gac?ggc?gaa?aga?gtg?cca?tta?gcg 403

Thr?Asn?Arg?Tyr?Arg?Ser?Ser?Val?Asp?Gly?Glu?Arg?Val?Pro?Leu?Ala

90 95 100

ccg?aag?att?gtg?atg?gca?gaa?acc?cga?ggg?gta?ttt?cat?gga?ccg?att 451

Pro?Lys?Ile?Val?Met?Ala?Glu?Thr?Arg?Gly?Val?Phe?His?Gly?Pro?Ile

105 110 115

acc?att?aac?gtg?ctc?gtg?cca?gca?cac?aat?gag?gcg?gaa?aga?att?act 499

Thr?Ile?Asn?Val?Leu?Val?Pro?Ala?His?Asn?Glu?Ala?Glu?Arg?Ile?Thr

120 125 130

gga?aca?att?cag?gca?ttg?aaa?tca?caa?cat?gag?cct?cca?gaa?cgc?atc 547

Gly?Thr?Ile?Gln?Ala?Leu?Lys?Ser?Gln?His?Glu?Pro?Pro?Glu?Arg?Ile

135 140 145

gtt?gta?gtt?gcc?gat?aat?tgc?act?gat?gaa?act?acg?gaa?tta?gcc?cgt 595

Val?Val?Val?Ala?Asp?Asn?Cys?Thr?Asp?Glu?Thr?Thr?Glu?Leu?Ala?Arg

150 155 160 165

gct?gag?gga?gtg?gag?gtc?ttg?gaa?aca?gtc?aat?aat?aag?ttt?aag?aag 643

Ala?Glu?Gly?Val?Glu?Val?Leu?Glu?Thr?Val?Asn?Asn?Lys?Phe?Lys?Lys

170 175 180

gcc?gga?gga?ctc?aat?cag?gct?ttg?agc?cgg?atg?ctt?ccc?aca?ttg?ggg 691

Ala?Gly?Gly?Leu?Asn?Gln?Ala?Leu?Ser?Arg?Met?Leu?Pro?Thr?Leu?Gly

185 190 195

gag?aat?gac?att?gtg?atg?atc?gtt?gac?gct?gat?aca?gca?ctt?gat?caa 739

Glu?Asn?Asp?Ile?Val?Met?Ile?Val?Asp?Ala?Asp?Thr?Ala?Leu?Asp?Gln

200 205 210

ggt?ttc?ctc?aag?gaa?gca?cgg?cgc?cgc?ttt?gag?tct?gat?cgc?gct?cta 787

Gly?Phe?Leu?Lys?Glu?Ala?Arg?Arg?Arg?Phe?Glu?Ser?Asp?Arg?Ala?Leu

215 220 225

atg?gcc?gtg?ggc?gga?ttg?ttc?tac?ggt?gag?tca?ggc?tcc?gga?tgg?ctt 835

Met?Ala?Val?Gly?Gly?Leu?Phe?Tyr?Gly?Glu?Ser?Gly?Ser?Gly?Trp?Leu

230 235 240 245

ggc?caa?tat?cag?cgc?aac?gaa?tac?acc?cgt?tat?agc?cgt?gac?atc?tat 883

Gly?Gln?Tyr?Gln?Arg?Asn?Glu?Tyr?Thr?Arg?Tyr?Ser?Arg?Asp?Ile?Tyr

250 255 260

cga?cgc?cgc?gga?cgt?gtg?ttt?gtt?ttg?act?gga?aca?gcg?tcg?gct?ttt 931

Arg?Arg?Arg?Gly?Arg?Val?Phe?Val?Leu?Thr?Gly?Thr?Ala?Ser?Ala?Phe

265 270 275

cgg?cca?cgc?ggc?ctg?cgg?aca?gta?gcg?gaa?tca?cgc?ggg?aca?ttg?atc 979

Arg?Pro?Arg?Gly?Leu?Arg?Thr?Val?Ala?Glu?Ser?Arg?Gly?Thr?Leu?Ile

280 285 290

ccc?gga?cgt?aaa?gcc?gat?gtt?tat?gac?acc?gcg?ggc?gtt?gac?cga?aga 1027

Pro?Gly?Arg?Lys?Ala?Asp?Val?Tyr?Asp?Thr?Ala?Gly?Val?Asp?Arg?Arg

295 300 305

taatgagttg?accctggctt?tga 1050

<210>422

<211>309

<212>PRT

＜213〉Corynebacterium glutamicum

<400>422

Met?Lys?Lys?Lys?Ser?Phe?Pro?Ile?Ala?Arg?Val?Ile?Gly?Ile?Gly?Val

1 5 10 15

Leu?Gly?Ile?Ala?Gly?Met?Gly?Ile?Leu?Leu?Leu?Trp?Leu?Ala?Val?Thr

20 25 30

Leu?Ser?Asp?Pro?Ala?Ser?Pro?Gly?Ala?Lys?Glu?Thr?Glu?Val?Phe?Asp

35 40 45

Arg?Trp?Lys?Val?Leu?Phe?Asp?Asp?Tyr?Ile?Pro?Pro?Val?Arg?Val?Leu

50 55 60

Val?Ala?Ala?Ile?Ile?Val?Ala?Leu?Ile?Phe?Val?Phe?Ile?Ala?Ala?Thr

65 70 75 80

Val?Glu?Arg?Thr?Val?Thr?Asn?Arg?Tyr?Arg?Ser?Ser?Val?Asp?Gly?Glu

85 90 95

Arg?Val?Pro?Leu?Ala?Pro?Lys?Ile?Val?Met?Ala?Glu?Thr?Arg?Gly?Val

100 105 110

Phe?His?Gly?Pro?Ile?Thr?Ile?Asn?Val?Leu?Val?Pro?Ala?His?Asn?Glu

115 120 125

Ala?Glu?Arg?Ile?Thr?Gly?Thr?Ile?Gln?Ala?Leu?Lys?Ser?Gln?His?Glu

130 135 140

Pro?Pro?Glu?Arg?Ile?Val?Val?Val?Ala?Asp?Asn?Cys?Thr?Asp?Glu?Thr

145 150 155 160

Thr?Glu?Leu?Ala?Arg?Ala?Glu?Gly?Val?Glu?Val?Leu?Glu?Thr?Val?Asn

165 170 175

Asn?Lys?Phe?Lys?Lys?Ala?Gly?Gly?Leu?Asn?Gln?Ala?Leu?Ser?Arg?Met

180 185 190

Leu?Pro?Thr?Leu?Gly?Glu?Asn?Asp?Ile?Val?Met?Ile?Val?Asp?Ala?Asp

195 200 205

Thr?Ala?Leu?Asp?Gln?Gly?Phe?Leu?Lys?Glu?Ala?Arg?Arg?Arg?Phe?Glu

210 215 220

Ser?Asp?Arg?Ala?Leu?Met?Ala?Val?Gly?Gly?Leu?Phe?Tyr?Gly?Glu?Ser

225 230 235 240

Gly?Ser?Gly?Trp?Leu?Gly?Gln?Tyr?Gln?Arg?Asn?Glu?Tyr?Thr?Arg?Tyr

245 250 255

Ser?Arg?Asp?Ile?Tyr?Arg?Arg?Arg?Gly?Arg?Val?Phe?Val?Leu?Thr?Gly

260 265 270

Thr?Ala?Ser?Ala?Phe?Arg?Pro?Arg?Gly?Leu?Arg?Thr?Val?Ala?Glu?Ser

275 280 285

Arg?Gly?Thr?Leu?Ile?Pro?Gly?Arg?Lys?Ala?Asp?Val?Tyr?Asp?Thr?Ala

290 295 300

Gly?Val?Asp?Arg?Arg

305

<210>423

<211>882

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(859)

<223>RXA00042

<400>423

gtggtctttg?actcaaacgg?ccagttacaa?caggtccatt?tagaccatca?agtaatttaa?60

atacgagcaa?aactttcctg?ataataaaag?gagtccgacc?atg?gac?atc?atc?atc 115

Met?Asp?Ile?Ile?Ile

1 5

tgc?aaa?gac?gag?caa?gaa?gtc?ggc?aaa?gca?gcg?gca?gcc?ctg?atc?gca 163

Cys?Lys?Asp?Glu?Gln?Glu?Val?Gly?Lys?Ala?Ala?Ala?Ala?Leu?Ile?Ala

10 15 20

ccc?ttc?gca?act?aag?ggc?gga?acc?ttg?ggg?ctt?gca?act?gga?tcg?tca 211

Pro?Phe?Ala?Thr?Lys?Gly?Gly?Thr?Leu?Gly?Leu?Ala?Thr?Gly?Ser?Ser

25 30 35

cct?ttg?agc?acc?tac?caa?gag?ctc?att?cgc?atg?tat?gaa?gct?ggg?gaa 259

Pro?Leu?Ser?Thr?Tyr?Gln?Glu?Leu?Ile?Arg?Met?Tyr?Glu?Ala?Gly?Glu

40 45 50

gtg?tca?ttc?aag?aac?tgc?aag?gca?ttc?ttg?ttg?gat?gaa?tac?gtg?gga 307

Val?Ser?Phe?Lys?Asn?Cys?Lys?Ala?Phe?Leu?Leu?Asp?Glu?Tyr?Val?Gly

55 60 65

tta?acg?cgc?gac?gat?gaa?aac?agc?tac?ttc?aaa?acc?att?cgt?aaa?gag 355

Leu?Thr?Arg?Asp?Asp?Glu?Asn?Ser?Tyr?Phe?Lys?Thr?Ile?Arg?Lys?Glu

70 75 80 85

ttc?act?gac?cac?atc?gac?atc?gtt?gat?gaa?gag?gtc?tac?agc?cca?gat 403

Phe?Thr?Asp?His?Ile?Asp?Ile?Val?Asp?Glu?Glu?Val?Tyr?Ser?Pro?Asp

90 95 100

ggt?gca?aac?cct?gat?cca?tac?gaa?gca?gct?gca?gag?tat?gag?gca?aag 451

Gly?Ala?Asn?Pro?Asp?Pro?Tyr?Glu?Ala?Ala?Ala?Glu?Tyr?Glu?Ala?Lys

105 110 115

atc?gct?gca?gaa?tcc?gtt?gat?gtt?caa?atc?ctt?ggc?atc?ggc?gga?aac 499

Ile?Ala?Ala?Glu?Ser?Val?Asp?Val?Gln?Ile?Leu?Gly?Ile?Gly?Gly?Asn

120 125 130

ggc?cac?atc?gct?ttc?aat?gag?cca?tca?tct?tct?ctg?tca?gga?ctg?aca 547

Gly?His?Ile?Ala?Phe?Asn?Glu?Pro?Ser?Ser?Ser?Leu?Ser?Gly?Leu?Thr

135 140 145

aag?gtc?cag?gcg?ctg?cac?cct?aaa?act?gtg?gag?gac?aac?gct?cga?ttc 595

Lys?Val?Gln?Ala?Leu?His?Pro?Lys?Thr?Val?Glu?Asp?Asn?Ala?Arg?Phe

150 155 160 165

ttc?aac?acc?atc?gaa?gag?gtc?cca?acc?cac?gcc?ctc?acc?cag?ggt?ttg 643

Phe?Asn?Thr?Ile?Glu?Glu?Val?Pro?Thr?His?Ala?Leu?Thr?Gln?Gly?Leu

170 175 180

ggc?act?ttg?tcc?cgc?gcg?caa?aac?atc?gtg?ttg?gtg?gca?act?ggt?gaa 691

Gly?Thr?Leu?Ser?Arg?Ala?Gln?Asn?Ile?Val?Leu?Val?Ala?Thr?Gly?Glu

185 190 195

gga?aaa?gcc?gac?gcc?atc?cgc?gga?act?gtg?gaa?ggc?cca?ctg?acc?gcc 739

Gly?Lys?Ala?Asp?Ala?Ile?Arg?Gly?Thr?Val?Glu?Gly?Pro?Leu?Thr?Ala

200 205 210

atg?tgc?cca?ggt?tcc?atc?ctg?cag?atg?cac?aac?aat?gcc?acc?atc?atc 787

Met?Cys?Pro?Gly?Ser?Ile?Leu?Gln?Met?His?Asn?Asn?Ala?Thr?Ile?Ile

215 220 225

gtt?gat?gaa?gca?gca?gca?tcc?aag?ctg?gaa?aac?gct?gat?cac?tac?cgt 835

Val?Asp?Glu?Ala?Ala?Ala?Ser?Lys?Leu?Glu?Asn?Ala?Asp?His?Tyr?Arg

230 235 240 245

ctc?atg?gag?caa?tta?aag?ctg?cgc?tagaaacaaa?aaggaaagta?gtg 882

Leu?Met?Glu?Gln?Leu?Lys?Leu?Arg

250

<210>424

<211>253

<212>PRT

＜213〉Corynebacterium glutamicum

<400>424

Met?Asp?Ile?Ile?Ile?Cys?Lys?Asp?Glu?Gln?Glu?Val?Gly?Lys?Ala?Ala

1 5 10 15

Ala?Ala?Leu?Ile?Ala?Pro?Phe?Ala?Thr?Lys?Gly?Gly?Thr?Leu?Gly?Leu

20 25 30

Ala?Thr?Gly?Ser?Ser?Pro?Leu?Ser?Thr?Tyr?Gln?Glu?Leu?Ile?Arg?Met

35 40 45

Tyr?Glu?Ala?Gly?Glu?Val?Ser?Phe?Lys?Asn?Cys?Lys?Ala?Phe?Leu?Leu

50 55 60

Asp?Glu?Tyr?Val?Gly?Leu?Thr?Arg?Asp?Asp?Glu?Asn?Ser?Tyr?Phe?Lys

65 70 75 80

Thr?Ile?Arg?Lys?Glu?Phe?Thr?Asp?His?Ile?Asp?Ile?Val?Asp?Glu?Glu

85 90 95

Val?Tyr?Ser?Pro?Asp?Gly?Ala?Asn?Pro?Asp?Pro?Tyr?Glu?Ala?Ala?Ala

100 105 110

Glu?Tyr?Glu?Ala?Lys?Ile?Ala?Ala?Glu?Ser?Val?Asp?Val?Gln?Ile?Leu

115 120 125

Gly?Ile?Gly?Gly?Asn?Gly?His?Ile?Ala?Phe?Asn?Glu?Pro?Ser?Ser?Ser

130 135 140

Leu?Ser?Gly?Leu?Thr?Lys?Val?Gln?Ala?Leu?His?Pro?Lys?Thr?Val?Glu

145 150 155 160

Asp?Asn?Ala?Arg?Phe?Phe?Asn?Thr?Ile?Glu?Glu?Val?Pro?Thr?His?Ala

165 170 175

Leu?Thr?Gln?Gly?Leu?Gly?Thr?Leu?Ser?Arg?Ala?Gln?Asn?Ile?Val?Leu

180 185 190

Val?Ala?Thr?Gly?Glu?Gly?Lys?Ala?Asp?Ala?Ile?Arg?Gly?Thr?Val?Glu

195 200 205

Gly?Pro?Leu?Thr?Ala?Met?Cys?Pro?Gly?Ser?Ile?Leu?Gln?Met?His?Asn

210 215 220

Asn?Ala?Thr?Ile?Ile?Val?Asp?Glu?Ala?Ala?Ala?Ser?Lys?Leu?Glu?Asn

225 230 235 240

Ala?Asp?His?Tyr?Arg?Leu?Met?Glu?Gln?Leu?Lys?Leu?Arg

245 250

<210>425

<211>1998

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1975)

<223>RXA01482

<400>425

ttgcgtgctg?caacttaatt?atggtcctcc?cagctcagtg?tgctgtgtgg?attgtttatt?60

ctcgtccatt?aagtgatcga?gaaaaagttg?ttgtaaagtc?atg?cgc?atg?tgt?gga 115

Met?Arg?Met?Cys?Gly

1 5

att?gtt?gga?tat?att?ggc?caa?gcg?ggc?gac?tcc?cgt?gat?tac?ttt?gct 163

Ile?Val?Gly?Tyr?Ile?Gly?Gln?Ala?Gly?Asp?Ser?Arg?Asp?Tyr?Phe?Ala

10 15 20

cta?gat?gta?gtt?gtt?gaa?gga?cta?cgt?cgc?ctg?gaa?tac?cgc?gga?tat 211

Leu?Asp?Val?Val?Val?Glu?Gly?Leu?Arg?Arg?Leu?Glu?Tyr?Arg?Gly?Tyr

25 30 35

gac?tcc?gca?ggt?att?gct?att?cac?gcc?aat?ggt?gag?att?agc?tac?cga 259

Asp?Ser?Ala?Gly?Ile?Ala?Ile?His?Ala?Asn?Gly?Glu?Ile?Ser?Tyr?Arg

40 45 50

aag?aag?gcc?gga?aag?gtt?gct?gca?cta?gat?gca?gaa?atc?gct?aaa?gca 307

Lys?Lys?Ala?Gly?Lys?Val?Ala?Ala?Leu?Asp?Ala?Glu?Ile?Ala?Lys?Ala

55 60 65

cct?ctt?cca?gat?tct?att?ttg?gga?att?gga?cac?acc?cgt?tgg?gca?act 355

Pro?Leu?Pro?Asp?Ser?Ile?Leu?Gly?Ile?Gly?His?Thr?Arg?Trp?Ala?Thr

70 75 80 85

cat?ggt?ggc?cca?acc?gat?gtc?aac?gct?cac?ccc?cac?gtt?gtt?tcc?aat 403

His?Gly?Gly?Pro?Thr?Asp?Val?Asn?Ala?His?Pro?His?Val?Val?Ser?Asn

90 95 100

ggc?aag?ctt?gcc?gta?gta?cac?aac?ggc?atc?atc?gaa?aac?ttt?gcg?gaa 451

Gly?Lys?Leu?Ala?Val?Val?His?Asn?Gly?Ile?Ile?Glu?Asn?Phe?Ala?Glu

105 110 115

ctg?cgc?tct?gag?ctt?tcc?gct?aag?ggc?tac?aac?ttt?gta?tcc?gat?acc 499

Leu?Arg?Ser?Glu?Leu?Ser?Ala?Lys?Gly?Tyr?Asn?Phe?Val?Ser?Asp?Thr

120 125 130

gat?acc?gaa?gtt?gct?gct?tct?ttg?ctt?gct?gaa?att?tac?aat?act?cag 547

Asp?Thr?Glu?Val?Ala?Ala?Ser?Leu?Leu?Ala?Glu?Ile?Tyr?Asn?Thr?Gln

135 140 145

gca?aac?ggt?gac?ctc?acc?ctt?gct?atg?cag?ctg?acc?ggt?cag?cgc?ctt 595

Ala?Asn?Gly?Asp?Leu?Thr?Leu?Ala?Met?Gln?Leu?Thr?Gly?Gln?Arg?Leu

150 155 160 165

gag?ggt?gct?ttc?acc?ctg?cta?gct?att?cat?gct?gat?cac?gat?gac?cgc 643

Glu?Gly?Ala?Phe?Thr?Leu?Leu?Ala?Ile?His?Ala?Asp?His?Asp?Asp?Arg

170 175 180

atc?gtt?gca?gct?cgt?cgt?aac?tct?cct?ttg?gtt?atc?ggc?gtc?ggc?gag 691

Ile?Val?Ala?Ala?Arg?Arg?Asn?Ser?Pro?Leu?Val?Ile?Gly?Val?Gly?Glu

185 190 195

ggc?gag?aac?ttc?ctc?gga?tct?gac?gtt?tct?ggc?ttt?att?gat?tac?acc 739

Gly?Glu?Asn?Phe?Leu?Gly?Ser?Asp?Val?Ser?Gly?Phe?Ile?Asp?Tyr?Thr

200 205 210

cgc?aag?gct?gta?gag?ctg?gct?aat?gac?cag?gtt?gtt?acc?atc?acc?gct 787

Arg?Lys?Ala?Val?Glu?Leu?Ala?Asn?Asp?Gln?Val?Val?Thr?Ile?Thr?Ala

215 220 225

gat?gat?tac?gcc?atc?acc?aac?ttt?gat?gga?tca?gaa?gca?gtt?ggc?aag 835

Asp?Asp?Tyr?Ala?Ile?Thr?Asn?Phe?Asp?Gly?Ser?Glu?Ala?Val?Gly?Lys

230 235 240 245

cct?ttc?gac?gtg?gag?tgg?gac?gct?gca?gct?gct?gaa?aag?ggt?ggc?ttc 883

Pro?Phe?Asp?Val?Glu?Trp?Asp?Ala?Ala?Ala?Ala?Glu?Lys?Gly?Gly?Phe

250 255 260

ggt?tcc?ttc?atg?gag?aag?gaa?atc?cac?gat?cag?cca?gca?gct?gtt?cgc 931

Gly?Ser?Phe?Met?Glu?Lys?Glu?Ile?His?Asp?Gln?Pro?Ala?Ala?Val?Arg

265 270 275

gat?acc?ctg?atg?ggc?cgt?ctt?gat?gaa?gat?ggc?aag?ctc?gtt?ctt?gat 979

Asp?Thr?Leu?Met?Gly?Arg?Leu?Asp?Glu?Asp?Gly?Lys?Leu?Val?Leu?Asp

280 285 290

gag?ctg?cgc?atc?gat?gaa?gct?att?ctg?cgt?agt?gtc?gac?aag?atc?gtc 1027

Glu?Leu?Arg?Ile?Asp?Glu?Ala?Ile?Leu?Arg?Ser?Val?Asp?Lys?Ile?Val

295 300 305

att?gtt?gct?tgt?ggt?act?gca?gct?tat?gca?ggc?cag?gtt?gct?cgt?tac 1075

Ile?Val?Ala?Cys?Gly?Thr?Ala?Ala?Tyr?Ala?Gly?Gln?Val?Ala?Arg?Tyr

310 315 320 325

gcc?att?gag?cac?tgg?tgc?cgc?atc?cca?acc?gag?gtg?gag?ctg?gct?cac 1123

Ala?Ile?Glu?His?Trp?Cys?Arg?Ile?Pro?Thr?Glu?Val?Glu?Leu?Ala?His

330 335 340

gag?ttc?cgt?tac?cgc?gac?cca?atc?ctc?aac?gag?aag?acc?ctt?gtt?gtg 1171

Glu?Phe?Arg?Tyr?Arg?Asp?Pro?Ile?Leu?Asn?Glu?Lys?Thr?Leu?Val?Val

345 350 355

gca?ttg?tcc?cag?tcc?ggc?gag?acc?atg?gat?acc?ctc?atg?gct?gtt?cgc 1219

Ala?Leu?Ser?Gln?Ser?Gly?Glu?Thr?Met?Asp?Thr?Leu?Met?Ala?Val?Arg

360 365 370

cac?gca?cgt?gag?cag?ggt?gcc?aag?gtt?gtt?gct?att?tgt?aac?act?gtt 1267

His?Ala?Arg?Glu?Gln?Gly?Ala?Lys?Val?Val?Ala?Ile?Cys?Asn?Thr?Val

375 380 385

gga?tcc?act?ctt?cca?cgt?gaa?gca?gat?gcg?tcc?ctg?tac?acc?tac?gct 1315

Gly?Ser?Thr?Leu?Pro?Arg?Glu?Ala?Asp?Ala?Ser?Leu?Tyr?Thr?Tyr?Ala

390 395 400 405

ggc?cct?gag?atc?gct?gtg?gcg?tcc?acc?aag?gcg?ttc?ttg?gct?cag?atc 1363

Gly?Pro?Glu?Ile?Ala?Val?Ala?Ser?Thr?Lys?Ala?Phe?Leu?Ala?Gln?Ile

410 415 420

act?gct?tct?tac?ttg?ctt?ggc?ctg?tac?ttg?gct?cag?ctg?cgc?ggc?aac 1411

Thr?Ala?Ser?Tyr?Leu?Leu?Gly?Leu?Tyr?Leu?Ala?Gln?Leu?Arg?Gly?Asn

425 430 435

aag?ttc?gct?gat?gag?gtt?tct?tcc?att?ctg?gac?agc?ctg?cgt?gag?atg 1459

Lys?Phe?Ala?Asp?Glu?Val?Ser?Ser?Ile?Leu?Asp?Ser?Leu?Arg?Glu?Met

440 445 450

cct?gag?aag?att?cag?cag?gtc?atc?gat?gca?gaa?gag?cag?atc?aag?aag 1507

Pro?Glu?Lys?Ile?Gln?Gln?Val?Ile?Asp?Ala?Glu?Glu?Gln?Ile?Lys?Lys

455 460 465

ctt?ggc?caa?gat?atg?gca?gat?gct?aag?tct?gtg?ctg?ttc?ctg?ggc?cgc 1555

Leu?Gly?Gln?Asp?Met?Ala?Asp?Ala?Lys?Ser?Val?Leu?Phe?Leu?Gly?Arg

470 475 480 485

cac?gtt?ggt?ttc?cca?gtt?gcg?ctt?gag?ggt?gcg?ttg?aag?ctc?aag?gag 1603

His?Val?Gly?Phe?Pro?Val?Ala?Leu?Glu?Gly?Ala?Leu?Lys?Leu?Lys?Glu

490 495 500

atc?gca?tac?ctg?cac?gct?gaa?ggt?ttc?gct?gca?ggc?gag?ctc?aag?cac 1651

Ile?Ala?Tyr?Leu?His?Ala?Glu?Gly?Phe?Ala?Ala?Gly?Glu?Leu?Lys?His

505 510 515

ggc?cca?att?gct?ttg?gtt?gag?gaa?ggc?cag?ccg?atc?ttc?gtt?atc?gtg 1699

Gly?Pro?Ile?Ala?Leu?Val?Glu?Glu?Gly?Gln?Pro?Ile?Phe?Val?Ile?Val

520 525 530

cct?tca?cct?cgt?ggt?cgc?gat?tcc?ctg?cac?tcc?aag?gtt?gtc?tcc?aac 1747

Pro?Ser?Pro?Arg?Gly?Arg?Asp?Ser?Leu?His?Ser?Lys?Val?Val?Ser?Asn

535 540 545

att?cag?gag?atc?cgt?gca?cgt?ggc?gct?gtc?acc?atc?gtg?att?gca?gag 1795

Ile?Gln?Glu?Ile?Arg?Ala?Arg?Gly?Ala?Val?Thr?Ile?Val?Ile?Ala?Glu

550 555 560 565

gaa?ggc?gat?gag?gct?gtc?aac?gat?tac?gcc?aac?ttc?atc?atc?cgc?att 1843

Glu?Gly?Asp?Glu?Ala?Val?Asn?Asp?Tyr?Ala?Asn?Phe?Ile?Ile?Arg?Ile

570 575 580

cct?cag?gcc?cca?acc?ctg?atg?cag?cct?ctg?ctg?tcc?acc?gtg?cct?ctg 1891

Pro?Gln?Ala?Pro?Thr?Leu?Met?Gln?Pro?Leu?Leu?Ser?Thr?Val?Pro?Leu

585 590 595

cag?atc?ttt?gcg?tgc?gct?gtg?gca?acc?gca?aag?ggc?tac?aac?gtg?gat 1939

Gln?Ile?Phe?Ala?Cys?Ala?Val?Ala?Thr?Ala?Lys?Gly?Tyr?Asn?Val?Asp

600 605 610

cag?cct?cgt?aac?ctg?gca?aag?tct?gtc?acc?gtc?gaa?taaaaagatt 1985

Gln?Pro?Arg?Asn?Leu?Ala?Lys?Ser?Val?Thr?Val?Glu

615 620 625

tcgcttctcg?acg 1998

<210>426

<211>625

<212>PRT

＜213〉Corynebacterium glutamicum

<400>426

Met?Arg?Met?Cys?Gly?Ile?Val?Gly?Tyr?Ile?Gly?Gln?Ala?Gly?Asp?Ser

1 5 10 15

Arg?Asp?Tyr?Phe?Ala?Leu?Asp?Val?Val?Val?Glu?Gly?Leu?Arg?Arg?Leu

20 25 30

Glu?Tyr?Arg?Gly?Tyr?Asp?Ser?Ala?Gly?Ile?Ala?Ile?His?Ala?Asn?Gly

35 40 45

Glu?Ile?Ser?Tyr?Arg?Lys?Lys?Ala?Gly?Lys?Val?Ala?Ala?Leu?Asp?Ala

50 55 60

Glu?Ile?Ala?Lys?Ala?Pro?Leu?Pro?Asp?Ser?Ile?Leu?Gly?Ile?Gly?His

65 70 75 80

Thr?Arg?Trp?Ala?Thr?His?Gly?Gly?Pro?Thr?Asp?Val?Asn?Ala?His?Pro

85 90 95

His?Val?Val?Ser?Asn?Gly?Lys?Leu?Ala?Val?Val?His?Asn?Gly?Ile?Ile

100 105 1l0

Glu?Asn?Phe?Ala?Glu?Leu?Arg?Ser?Glu?Leu?Ser?Ala?Lys?Gly?Tyr?Asn

115 120 125

Phe?Val?Ser?Asp?Thr?Asp?Thr?Glu?Val?Ala?Ala?Ser?Leu?Leu?Ala?Glu

130 135 140

Ile?Tyr?Asn?Thr?Gln?Ala?Asn?Gly?Asp?Leu?Thr?Leu?Ala?Met?Gln?Leu

145 150 155 160

Thr?Gly?Gln?Arg?Leu?Glu?Gly?Ala?Phe?Thr?Leu?Leu?Ala?Ile?His?Ala

165 170 175

Asp?His?Asp?Asp?Arg?Ile?Val?Ala?Ala?Arg?Arg?Asn?Ser?Pro?Leu?Val

180 185 190

Ile?Gly?Val?Gly?Glu?Gly?Glu?Asn?Phe?Leu?Gly?Ser?Asp?Val?Ser?Gly

195 200 205

Phe?Ile?Asp?Tyr?Thr?Arg?Lys?Ala?Val?Glu?Leu?Ala?Asn?Asp?Gln?Val

210 215 220

Val?Thr?Ile?Thr?Ala?Asp?Asp?Tyr?Ala?Ile?Thr?Asn?Phe?Asp?Gly?Ser

225 230 235 240

Glu?Ala?Val?Gly?Lys?Pro?Phe?Asp?Val?Glu?Trp?Asp?Ala?Ala?Ala?Ala

245 250 255

Glu?Lys?Gly?Gly?Phe?Gly?Ser?Phe?Met?Glu?Lys?Glu?Ile?His?Asp?Gln

260 265 270

Pro?Ala?Ala?Val?Arg?Asp?Thr?Leu?Met?Gly?Arg?Leu?Asp?Glu?Asp?Gly

275 280 285

Lys?Leu?Val?Leu?Asp?Glu?Leu?Arg?Ile?Asp?Glu?Ala?Ile?Leu?Arg?Ser

290 295 300

Val?Asp?Lys?Ile?Val?Ile?Val?Ala?Cys?Gly?Thr?Ala?Ala?Tyr?Ala?Gly

305 310 315 320

Gln?Val?Ala?Arg?Tyr?Ala?Ile?Glu?His?Trp?Cys?Arg?Ile?Pro?Thr?Glu

325 330 335

Val?Glu?Leu?Ala?His?Glu?Phe?Arg?Tyr?Arg?Asp?Pro?Ile?Leu?Asn?Glu

340 345 350

Lys?Thr?Leu?Val?Val?Ala?Leu?Ser?Gln?Ser?Gly?Glu?Thr?Met?Asp?Thr

355 360 365

Leu?Met?Ala?Val?Arg?His?Ala?Arg?Glu?Gln?Gly?Ala?Lys?Val?Val?Ala

370 375 380

Ile?Cys?Asn?Thr?Val?Gly?Ser?Thr?Leu?Pro?Arg?Glu?Ala?Asp?Ala?Ser

385 390 395 400

Leu?Tyr?Thr?Tyr?Ala?Gly?Pro?Glu?Ile?Ala?Val?Ala?Ser?Thr?Lys?Ala

405 410 415

Phe?Leu?Ala?Gln?Ile?Thr?Ala?Ser?Tyr?Leu?Leu?Gly?Leu?Tyr?Leu?Ala

420 425 430

Gln?Leu?Arg?Gly?Asn?Lys?Phe?Ala?Asp?Glu?Val?Ser?Ser?Ile?Leu?Asp

435 440 445

Ser?Leu?Arg?Glu?Met?Pro?Glu?Lys?Ile?Gln?Gln?Val?Ile?Asp?Ala?Glu

450 455 460

Glu?Gln?Ile?Lys?Lys?Leu?Gly?Gln?Asp?Met?Ala?Asp?Ala?Lys?Ser?Val

465 470 475 480

Leu?Phe?Leu?Gly?Arg?His?Val?Gly?Phe?Pro?Val?Ala?Leu?Glu?Gly?Ala

485 490 495

Leu?Lys?Leu?Lys?Glu?Ile?Ala?Tyr?Leu?His?Ala?Glu?Gly?Phe?Ala?Ala

500 505 510

Gly?Glu?Leu?Lys?His?Gly?Pro?Ile?Ala?Leu?Val?Glu?Glu?Gly?Gln?Pro

515 520 525

Ile?Phe?Val?Ile?Val?Pro?Ser?Pro?Arg?Gly?Arg?Asp?Ser?Leu?His?Ser

530 535 540

Lys?Val?Val?Ser?Asn?Ile?Gln?Glu?Ile?Arg?Ala?Arg?Gly?Ala?Val?Thr

545 550 555 560

Ile?Val?Ile?Ala?Glu?Glu?Gly?Asp?Glu?Ala?Val?Asn?Asp?Tyr?Ala?Asn

565 570 575

Phe?Ile?Ile?Arg?Ile?Pro?Gln?Ala?Pro?Thr?Leu?Met?Gln?Pro?Leu?Leu

580 585 590

Ser?Thr?Val?Pro?Leu?Gln?Ile?Phe?Ala?Cys?Ala?Val?Ala?Thr?Ala?Lys

595 600 605

Gly?Tyr?Asn?Val?Asp?Gln?Pro?Arg?Asn?Leu?Ala?Lys?Ser?Val?Thr?Val

610 615 620

Glu

625

<210>427

<211>666

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(666)

<223>RXN03179

<400>427

gct?cgt?gag?gca?tgg?cgc?att?ttc?atg?tcc?cac?tgg?gat?ctc?tac?gca 48

Ala?Arg?Glu?Ala?Trp?Arg?Ile?Phe?Met?Ser?His?Trp?Asp?Leu?Tyr?Ala

1 5 10 15

gga?acc?gca?act?ggc?tac?tgg?gtg?gag?cag?gaa?ttt?gag?cac?gtt?ttc 96

Gly?Thr?Ala?Thr?Gly?Tyr?Trp?Val?Glu?Gln?Glu?Phe?Glu?His?Val?Phe

20 25 30

ggc?atc?aac?gcg?gag?cgc?ctg?aat?gtt?ggc?acc?cca?gaa?cat?gct?gac 144

Gly?Ile?Asn?Ala?Glu?Arg?Leu?Asn?Val?Gly?Thr?Pro?Glu?His?Ala?Asp

35 40 45

gcc?atc?ttt?gat?gag?ctg?acc?gat?att?ctt?gcc?aag?cca?gat?ttc?cga 192

Ala?Ile?Phe?Asp?Glu?Leu?Thr?Asp?Ile?Leu?Ala?Lys?Pro?Asp?Phe?Arg

50 55 60

cca?cgc?gca?ctg?gct?gag?cag?ttc?aac?ttg?gaa?gtt?cta?gcc?acc?acc 240

Pro?Arg?Ala?Leu?Ala?Glu?Gln?Phe?Asn?Leu?Glu?Val?Leu?Ala?Thr?Thr

65 70 75 80

gac?gat?ccg?ctc?gat?gac?ctg?gca?gat?cac?aag?gca?ctg?gca?gat?gat 288

Asp?Asp?Pro?Leu?Asp?Asp?Leu?Ala?Asp?His?Lys?Ala?Leu?Ala?Asp?Asp

85 90 95

cca?acc?ttc?tcc?cct?cgt?gtg?ctc?cct?acc?ttc?cgc?cca?gac?gca?tac 336

Pro?Thr?Phe?Ser?Pro?Arg?Val?Leu?Pro?Thr?Phe?Arg?Pro?Asp?Ala?Tyr

100 105 110

acc?aag?atg?tac?aac?gct?ggt?tgg?gca?gaa?aaa?acc?acc?aag?ctt?atc 384

Thr?Lys?Met?Tyr?Asn?Ala?Gly?Trp?Ala?Glu?Lys?Thr?Thr?Lys?Leu?Ile

115 120 125

gat?acc?gca?ggt?gac?ggc?aag?gca?ggc?tgg?gag?ggt?tac?ctt?cag?gca 432

Asp?Thr?Ala?Gly?Asp?Gly?Lys?Ala?Gly?Trp?Glu?Gly?Tyr?Leu?Gln?Ala

130 135 140

atg?cgc?aac?cgc?cgc?cag?tacttc?atc?aat?cac?ggt?gca?acc?tcc?gcg 480

Met?Arg?Asn?Arg?Arg?Gln?Tyr?Phe?Ile?Asn?His?Gly?Ala?Thr?Ser?Ala

145 150 155 160

gac?cac?ggt?ctc?cac?gac?acc?gac?acc?acc?cca?ctg?agc?cac?aaa?gat 528

Asp?His?Gly?Leu?His?Asp?Thr?Asp?Thr?Thr?Pro?Leu?Ser?His?Lys?Asp

165 170 175

gcc?cag?aag?atc?ttg?gac?aag?ggt?ctc?gct?ggc?aca?gca?acc?ttg?gct 576

Ala?Gln?Lys?Ile?Leu?Asp?Lys?Gly?Leu?Ala?Gly?Thr?Ala?Thr?Leu?Ala

180 185 190

gaa?atg?cat?gcc?ttc?gaa?gcc?aac?acc?acc?tac?cgt?tcg?cgg?aaa?tgt 624

Glu?Met?His?Ala?Phe?Glu?Ala?Asn?Thr?Thr?Tyr?Arg?Ser?Arg?Lys?Cys

195 200 205

cca?aga?aga?cgg?ctg?gtc?atg?acc?atc?cac?cag?gtg?tgt?acc 666

Pro?Arg?Arg?Arg?Leu?Val?Met?Thr?Ile?His?Gln?Val?Cys?Thr

210 215 220

<210>428

<211>222

<212>PRT

＜213〉Corynebacterium glutamicum

<400>428

Ala?Arg?Glu?Ala?Trp?Arg?Ile?Phe?Met?Ser?His?Trp?Asp?Leu?Tyr?Ala

1 5 10 15

Gly?Thr?Ala?Thr?Gly?Tyr?Trp?Val?Glu?Gln?Glu?Phe?Glu?His?Val?Phe

20 25 30

Gly?Ile?Asn?Ala?Glu?Arg?Leu?Asn?Val?Gly?Thr?Pro?Glu?His?Ala?Asp

35 40 45

Ala?Ile?Phe?Asp?Glu?Leu?Thr?Asp?Ile?Leu?Ala?Lys?Pro?Asp?Phe?Arg

50 55 60

Pro?Arg?Ala?Leu?Ala?Glu?Gln?Phe?Asn?Leu?Glu?Val?Leu?Ala?Thr?Thr

65 70 75 80

Asp?Asp?Pro?Leu?Asp?Asp?Leu?Ala?Asp?His?Lys?Ala?Leu?Ala?Asp?Asp

85 90 95

Pro?Thr?Phe?Ser?Pro?Arg?Val?Leu?Pro?Thr?Phe?Arg?Pro?Asp?Ala?Tyr

100 105 110

Thr?Lys?Met?Tyr?Asn?Ala?Gly?Trp?Ala?Glu?Lys?Thr?Thr?Lys?Leu?Ile

115 120 125

Asp?Thr?Ala?Gly?Asp?Gly?Lys?Ala?Gly?Trp?Glu?Gly?Tyr?Leu?Gln?Ala

130 135 140

Met?Arg?Asn?Arg?Arg?Gln?Tyr?Phe?Ile?Asn?His?Gly?Ala?Thr?Ser?Ala

145 150 155 160

Asp?His?Gly?Leu?His?Asp?Thr?Asp?Thr?Thr?Pro?Leu?Ser?His?Lys?Asp

165 170 175

Ala?Gln?Lys?Ile?Leu?Asp?Lys?Gly?Leu?Ala?Gly?Thr?Ala?Thr?Leu?Ala

180 185 190

Glu?Met?His?Ala?Phe?Glu?Ala?Asn?Thr?Thr?Tyr?Arg?Ser?Arg?Lys?Cys

195 200 205

Pro?Arg?Arg?Arg?Leu?Val?Met?Thr?Ile?His?Gln?Val?Cys?Thr

210 215 220

<210>429

<211>672

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(672)

<223>FRXA02872

<400>429

gct?cgt?gag?gca?tgg?cgc?att?ttc?atg?tcc?cac?tgg?gat?ctc?tac?gca 48

Ala?Arg?Glu?Ala?Trp?Arg?Ile?Phe?Met?Ser?His?Trp?Asp?Leu?Tyr?Ala

1 5 10 15

gga?acc?gca?act?ggc?tac?tgg?gtg?gag?cag?gaa?ttt?gag?cac?gtt?ttc 96

Gly?Thr?Ala?Thr?Gly?Tyr?Trp?Val?Glu?Gln?Glu?Phe?Glu?His?Val?Phe

20 25 30

ggc?atc?aac?gcg?gag?cgc?ctg?aat?gtt?ggc?acc?cca?gaa?cat?gct?gac 144

Gly?Ile?Asn?Ala?Glu?Arg?Leu?Asn?Val?Gly?Thr?Pro?Glu?His?Ala?Asp

35 40 45

gcc?atc?ttt?gat?gag?ctg?acc?gat?att?ctt?gcc?aag?cca?gat?ttc?cga 192

Ala?Ile?Phe?Asp?Glu?Leu?Thr?Asp?Ile?Leu?Ala?Lys?Pro?Asp?Phe?Arg

50 55 60

cca?cgc?gca?ctg?gct?gag?cag?ttc?aac?ttg?gaa?gtt?cta?gcc?acc?acc 240

Pro?Arg?Ala?Leu?Ala?Glu?Gln?Phe?Asn?Leu?Glu?Val?Leu?Ala?Thr?Thr

65 70 75 80

gac?gat?ccg?ctc?gat?gac?ctg?gca?gat?cac?aag?gca?ctg?gca?gat?gat 288

Asp?Asp?Pro?Leu?Asp?Asp?Leu?Ala?Asp?His?Lys?Ala?Leu?Ala?Asp?Asp

85 90 95

cca?acc?ttc?tcc?cct?cgt?gtg?ctc?cct?acc?ttc?cgc?cca?gac?gca?tac 336

Pro?Thr?Phe?Ser?Pro?Arg?Val?Leu?Pro?Thr?Phe?Arg?Pro?Asp?Ala?Tyr

100 105 110

acc?aag?atg?tac?aac?gct?ggt?tgg?gca?gaa?aaa?acc?acc?aag?ctt?atc 384

Thr?Lys?Met?Tyr?Asn?Ala?Gly?Trp?Ala?Glu?Lys?Thr?Thr?Lys?Leu?Ile

115 120 125

gat?acc?gca?ggt?gac?ggc?aag?gca?ggc?tgg?gag?ggt?tac?ctt?cag?gca 432

Asp?Thr?Ala?Gly?Asp?Gly?Lys?Ala?Gly?Trp?Glu?Gly?Tyr?Leu?Gln?Ala

130 135 140

atg?cgc?aac?cgc?cgc?cag?tacttc?atc?aat?cac?ggt?gca?acc?tcc?gcg 480

Met?Arg?Asn?Arg?Arg?Gln?Tyr?Phe?Ile?Asn?His?Gly?Ala?Thr?Ser?Ala

145 150 155 160

gac?cac?ggt?ctc?cac?gac?acc?gac?acc?acc?cca?ctg?agc?cac?aaa?gat 528

Asp?His?Gly?Leu?His?Asp?Thr?Asp?Thr?Thr?Pro?Leu?Ser?His?Lys?Asp

165 170 175

gcc?cag?aag?atc?ttg?gac?aag?ggt?ctc?gct?ggc?aca?gca?acc?ttg?gct 576

Ala?Gln?Lys?Ile?Leu?Asp?Lys?Gly?Leu?Ala?Gly?Thr?Ala?Thr?Leu?Ala

180 185 190

gaa?atg?cat?gcc?ttc?gaa?gcc?aac?acc?acc?tac?cgt?ttc?gcg?gaa?atg 624

Glu?Met?His?Ala?Phe?Glu?Ala?Asn?Thr?Thr?Tyr?Arg?Phe?Ala?Glu?Met

195 200 205

tcc?caa?gaa?gac?ggc?ctg?gtc?atg?acc?atc?cac?cca?ggt?gtg?tac?cgc 672

Ser?Gln?Glu?Asp?Gly?Leu?Val?Met?Thr?Ile?His?Pro?Gly?Val?Tyr?Arg

210 215 220

<210>430

<211>224

<212>PRT

＜213〉Corynebacterium glutamicum

<400>430

Ala?Arg?Glu?Ala?Trp?Arg?Ile?Phe?Met?Ser?His?Trp?Asp?Leu?Tyr?Ala

1 5 10 15

Gly?Thr?Ala?Thr?Gly?Tyr?Trp?Val?Glu?Gln?Glu?Phe?Glu?His?Val?Phe

20 25 30

Gly?Ile?Asn?Ala?Glu?Arg?Leu?Asn?Val?Gly?Thr?Pro?Glu?His?Ala?Asp

35 40 45

Ala?Ile?Phe?Asp?Glu?Leu?Thr?Asp?Ile?Leu?Ala?Lys?Pro?Asp?Phe?Arg

50 55 60

Pro?Arg?Ala?Leu?Ala?Glu?Gln?Phe?Asn?Leu?Glu?Val?Leu?Ala?Thr?Thr

65 70 75 80

Asp?Asp?Pro?Leu?Asp?Asp?Leu?Ala?Asp?His?Lys?Ala?Leu?Ala?Asp?Asp

85 90 95

Pro?Thr?Phe?Ser?Pro?Arg?Val?Leu?Pro?Thr?Phe?Arg?Pro?Asp?Ala?Tyr

100 105 110

Thr?Lys?Met?Tyr?Asn?Ala?Gly?Trp?Ala?Glu?Lys?Thr?Thr?Lys?Leu?Ile

115 120 125

Asp?Thr?Ala?Gly?Asp?Gly?Lys?Ala?Gly?Trp?Glu?Gly?Tyr?Leu?Gln?Ala

130 135 140

Met?Arg?Asn?Arg?Arg?Gln?Tyr?Phe?Ile?Asn?His?Gly?Ala?Thr?Ser?Ala

145 150 155 160

Asp?His?Gly?Leu?His?Asp?Thr?Asp?Thr?Thr?Pro?Leu?Ser?His?Lys?Asp

165 170 175

Ala?Gln?Lys?Ile?Leu?Asp?Lys?Gly?Leu?Ala?Gly?Thr?Ala?Thr?Leu?Ala

180 185 190

Glu?Met?His?Ala?Phe?Glu?Ala?Asn?Thr?Thr?Tyr?Arg?Phe?Ala?Glu?Met

195 200 205

Ser?Gln?Glu?Asp?Gly?Leu?Val?Met?Thr?Ile?His?Pro?Gly?Val?Tyr?Arg

210 215 220

<210>431

<211>533

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(510)

<223>RXN03180

<400>431

ttc?ggt?gag?aac?aaa?gat?ctc?atc?tct?gac?agc?agt?ttc?aac?cgc?tgg 48

Phe?Gly?Glu?Asn?Lys?Asp?Leu?Ile?Ser?Asp?Ser?Ser?Phe?Asn?Arg?Trp

1 5 10 15

ctg?cgt?acg?gtt?tcc?ctc?gga?tcg?acc?cag?gat?gcc?gat?atg?gct?gca 96

Leu?Arg?Thr?Val?Ser?Leu?Gly?Ser?Thr?Gln?Asp?Ala?Asp?Met?Ala?Ala

20 25 30

gct?tcc?aac?ttg?gca?gcc?aat?tct?aaa?atg?gcc?cgc?cag?aac?acc?cgc 144

Ala?Ser?Asn?Leu?Ala?Ala?Asn?Ser?Lys?Met?Ala?Arg?Gln?Asn?Thr?Arg

35 40 45

gat?atc?ctc?gac?gca?gtc?tct?gat?ggt?ggc?gtc?atg?ctc?ggc?cga?aac 192

Asp?Ile?Leu?Asp?Ala?Val?Ser?Asp?Gly?Gly?Val?Met?Leu?Gly?Arg?Asn

50 55 60

ggt?gcc?cta?gtg?ttg?gga?cct?gtg?gtt?gga?act?ctc?cac?att?aaa?ttc 240

Gly?Ala?Leu?Val?Leu?Gly?Pro?Val?Val?Gly?Thr?Leu?His?Ile?Lys?Phe

65 70 75 80

att?gcg?cct?ttg?aac?aag?cgt?gtg?gaa?aga?gtc?atg?tac?aaa?act?gga 288

Ile?Ala?Pro?Leu?Asn?Lys?Arg?Val?Glu?Arg?Val?Met?Tyr?Lys?Thr?Gly

85 90 95

ctc?tca?gaa?gct?gct?gca?gct?gag?caa?tgt?gct?ttg?gag?gat?cgt?ctc 336

Leu?Ser?Glu?Ala?Ala?Ala?Ala?Glu?Gln?Cys?Ala?Leu?Glu?Asp?Arg?Leu

100 105 110

cgc?gaa?gag?atg?gcc?cac?gct?ttg?tat?caa?tgg?aat?ccg?gga?cgc?gat 384

Arg?Glu?Glu?Met?Ala?His?Ala?Leu?Tyr?Gln?Trp?Asn?Pro?Gly?Arg?Asp

115 120 125

gaa?aac?tat?gac?ctc?gtg?atc?aac?acc?ggt?tcg?atg?aca?tac?gaa?caa 432

Glu?Asn?Tyr?Asp?Leu?Val?Ile?Asn?Thr?Gly?Ser?Met?Thr?Tyr?Glu?Gln

130 135 140

atc?gtt?gat?cta?gtt?gtg?gaa?act?tac?gcc?agg?aag?tat?ccg?ctc?cac 480

Ile?Val?Asp?Leu?Val?Val?Glu?Thr?Tyr?Ala?Arg?Lys?Tyr?Pro?Leu?His

145 150 155 160

gtg?aga?atc?att?ccg?aac?gga?aaa?gac?caa?taaacataca?gtccccgtga 530

Val?Arg?Ile?Ile?Pro?Asn?Gly?Lys?Asp?Gln

165 170

tgt 533

<210>432

<211>170

<212>PRT

＜213〉Corynebacterium glutamicum

<400>432

Phe?Gly?Glu?Asn?Lys?Asp?Leu?Ile?Ser?Asp?Ser?Ser?Phe?Asn?Arg?Trp

1 5 10 15

Leu?Arg?Thr?Val?Ser?Leu?Gly?Ser?Thr?Gln?Asp?Ala?Asp?Met?Ala?Ala

20 25 30

Ala?Ser?Asn?Leu?Ala?Ala?Asn?Ser?Lys?Met?Ala?Arg?Gln?Asn?Thr?Arg

35 40 45

Asp?Ile?Leu?Asp?Ala?Val?Ser?Asp?Gly?Gly?Val?Met?Leu?Gly?Arg?Asn

50 55 60

Gly?Ala?Leu?Val?Leu?Gly?Pro?Val?Val?Gly?Thr?Leu?His?Ile?Lys?Phe

65 70 75 80

Ile?Ala?Pro?Leu?Asn?Lys?Arg?Val?Glu?Arg?Val?Met?Tyr?Lys?Thr?Gly

85 90 95

Leu?Ser?Glu?Ala?Ala?Ala?Ala?Glu?Gln?Cys?Ala?Leu?Glu?Asp?Arg?Leu

100 105 110

Arg?Glu?Glu?Met?Ala?His?Ala?Leu?Tyr?Gln?Trp?Asn?Pro?Gly?Arg?Asp

115 120 125

Glu?Asn?Tyr?Asp?Leu?Val?Ile?Asn?Thr?Gly?Ser?Met?Thr?Tyr?Glu?Gln

130 135 140

Ile?Val?Asp?Leu?Val?Val?Glu?Thr?Tyr?Ala?Arg?Lys?Tyr?Pro?Leu?His

145 150 155 160

Val?Arg?Ile?Ile?Pro?Asn?Gly?Lys?Asp?Gln

165 170

<210>433

<211>533

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(510)

<223>FRXA02873

<400>433

ttc?ggt?gag?aac?aaa?gat?ctc?atc?tct?gac?agc?agt?ttc?aac?cgc?tgg 48

Phe?Gly?Glu?Asn?Lys?Asp?Leu?Ile?Ser?Asp?Ser?Ser?Phe?Asn?Arg?Trp

1 5 10 15

ctg?cgt?acg?gtt?tcc?ctc?gga?tcg?acc?cag?gat?gcc?gat?atg?gct?gca 96

Leu?Arg?Thr?Val?Ser?Leu?Gly?Ser?Thr?Gln?Asp?Ala?Asp?Met?Ala?Ala

20 25 30

gct?tcc?aac?ttg?gca?gcc?aat?tct?aaa?atg?gcc?cgc?cag?aac?acc?cgc 144

Ala?Ser?Asn?Leu?Ala?Ala?Asn?Ser?Lys?Met?Ala?Arg?Gln?Asn?Thr?Arg

35 40 45

gat?atc?ctc?gac?gca?gtc?tct?gat?ggt?ggc?gtc?atg?ctc?ggc?cga?aac 192

Asp?Ile?Leu?Asp?Ala?Val?Ser?Asp?Gly?Gly?Val?Met?Leu?Gly?Arg?Asn

50 55 60

ggt?gcc?cta?gtg?ttg?gga?cct?gtg?gtt?gga?act?ctc?cac?att?aaa?ttc 240

Gly?Ala?Leu?Val?Leu?Gly?Pro?Val?Val?Gly?Thr?Leu?His?Ile?Lys?Phe

65 70 75 80

att?gcg?cct?ttg?aac?aag?cgt?gtg?gaa?aga?gtc?atg?tac?aaa?act?gga 288

Ile?Ala?Pro?Leu?Asn?Lys?Arg?Val?Glu?Arg?Val?Met?Tyr?Lys?Thr?Gly

85 90 95

ctc?tca?gaa?gct?gct?gca?gct?gag?caa?tgt?gct?ttg?gag?gat?cgt?ctc 336

Leu?Ser?Glu?Ala?Ala?Ala?Ala?Glu?Gln?Cys?Ala?Leu?Glu?Asp?Arg?Leu

100 105 110

cgc?gaa?gag?atg?gcc?cac?gct?ttg?tat?caa?tgg?aat?ccg?gga?cgc?gat 384

Arg?Glu?Glu?Met?Ala?His?Ala?Leu?Tyr?Gln?Trp?Asn?Pro?Gly?Arg?Asp

115 120 125

gaa?aac?tat?gac?ctc?gtg?atc?aac?acc?ggt?tcg?atg?aca?tac?gaa?caa 432

Glu?Asn?Tyr?Asp?Leu?Val?Ile?Asn?Thr?Gly?Ser?Met?Thr?Tyr?Glu?Gln

130 135 140

atc?gtt?gat?cta?gtt?gtg?gaa?act?tac?gcc?agg?aag?tat?ccg?ctc?cac 480

Ile?Val?Asp?Leu?Val?Val?Glu?Thr?Tyr?Ala?Arg?Lys?Tyr?Pro?Leu?His

145 150 155 160

gtg?aga?atc?att?ccg?aac?gga?aaa?gac?caa?taaacataca?gtccccgtga 530

Val?Arg?Ile?Ile?Pro?Asn?Gly?Lys?Asp?Gln

165 170

tgt 533

<210>434

<211>170

<212>PRT

＜213〉Corynebacterium glutamicum

<400>434

Phe?Gly?Glu?Asn?Lys?Asp?Leu?Ile?Ser?Asp?Ser?Ser?Phe?Asn?Arg?Trp

1 5 10 15

Leu?Arg?Thr?Val?Ser?Leu?Gly?Ser?Thr?Gln?Asp?Ala?Asp?Met?Ala?Ala

20 25 30

Ala?Ser?Asn?Leu?Ala?Ala?Asn?Ser?Lys?Met?Ala?Arg?Gln?Asn?Thr?Arg

35 40 45

Asp?Ile?Leu?Asp?Ala?Val?Ser?Asp?Gly?Gly?Val?Met?Leu?Gly?Arg?Asn

50 55 60

Gly?Ala?Leu?Val?Leu?Gly?Pro?Val?Val?Gly?Thr?Leu?His?Ile?Lys?Phe

65 70 75 80

Ile?Ala?Pro?Leu?Asn?Lys?Arg?Val?Glu?Arg?Val?Met?Tyr?Lys?Thr?Gly

85 90 95

Leu?Ser?Glu?Ala?Ala?Ala?Ala?Glu?Gln?Cys?Ala?Leu?Glu?Asp?Arg?Leu

100 105 110

Arg?Glu?Glu?Met?Ala?His?Ala?Leu?Tyr?Gln?Trp?Asn?Pro?Gly?Arg?Asp

115 120 125

Glu?Asn?Tyr?Asp?Leu?Val?Ile?Asn?Thr?Gly?Ser?Met?Thr?Tyr?Glu?Gln

130 135 140

Ile?Val?Asp?Leu?Val?Val?Glu?Thr?Tyr?Ala?Arg?Lys?Tyr?Pro?Leu?His

145 150 155 160

Val?Arg?Ile?Ile?Pro?Asn?Gly?Lys?Asp?Gln

165 170

<210>435

<211>798

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(775)

<223>RXA02292

<400>435

tgcaccacgc?cagctgcaac?cctgcgcggt?ggtctgggaa?gttggtggag?gggatcgtcg?60

aaaagcgtag?gcactaaagt?tctcctgcac?aatggaggat?atg?gac?aat?gac?ttt 115

Met?Asp?Asn?Asp?Phe

1 5

gaa?tct?atc?gag?aaa?atg?agc?agc?ggc?gat?tgg?tac?gtg?gct?acc?ggc 163

Glu?Ser?Ile?Glu?Lys?Met?Ser?Ser?Gly?Asp?Trp?Tyr?Val?Ala?Thr?Gly

10 15 20

gcg?gaa?cgt?gaa?gaa?gtg?gca?caa?aaa?aca?gcg?tta?ctt?ttc?cac?gaa 211

Ala?Glu?Arg?Glu?Glu?Val?Ala?Gln?Lys?Thr?Ala?Leu?Leu?Phe?His?Glu

25 30 35

tac?aac?caa?att?gga?cct?aca?gac?ccc?gca?cga?act?gcc?gaa?ata?cta 259

Tyr?Asn?Gln?Ile?Gly?Pro?Thr?Asp?Pro?Ala?Arg?Thr?Ala?Glu?Ile?Leu

40 45 50

aga?act?gta?cta?aat?cct?gcc?agc?gga?acc?tgc?acg?atc?aaa?gcg?cca 307

Arg?Thr?Val?Leu?Asn?Pro?Ala?Ser?Gly?Thr?Cys?Thr?Ile?Lys?Ala?Pro

55 60 65

gcc?atc?att?gaa?tac?ggc?ttc?aac?acc?acg?atc?ggc?gag?cat?gtg?ttc 355

Ala?Ile?Ile?Glu?Tyr?Gly?Phe?Asn?Thr?Thr?Ile?Gly?Glu?His?Val?Phe

70 75 80 85

atc?aac?ttt?ggc?ctc?acc?att?tta?gat?atc?gca?ccg?gtt?cgc?atc?ggg 403

Ile?Asn?Phe?Gly?Leu?Thr?Ile?Leu?Asp?Ile?Ala?Pro?Val?Arg?Ile?Gly

90 95 100

gca?cgc?agc?atg?ctc?ggg?cca?aac?tgt?cag?ctc?ttc?acc?gca?ggt?cac 451

Ala?Arg?Ser?Met?Leu?Gly?Pro?Asn?Cys?Gln?Leu?Phe?Thr?Ala?Gly?His

105 110 115

ccg?gtc?gat?gac?tgg?gaa?atg?cgc?tcc?ggt?ggg?tgg?gaa?aat?ggc?gca 499

Pro?Val?Asp?Asp?Trp?Glu?Met?Arg?Ser?Gly?Gly?Trp?Glu?Asn?Gly?Ala

120 125 130

ccc?att?tcc?att?ggc?gag?gat?acg?tgg?ctg?ggt?gga?aat?gtc?acc?gtc 547

Pro?Ile?Ser?Ile?Gly?Glu?Asp?Thr?Trp?Leu?Gly?Gly?Asn?Val?Thr?Val

135 140 145

gtt?ggt?ggc?gtg?agc?att?ggc?gat?agg?tgt?gtg?att?ggc?gcg?ggg?ccc 595

Val?Gly?Gly?Val?Ser?Ile?Gly?Asp?Arg?Cys?Val?Ile?Gly?Ala?Gly?Pro

150 155 160 165

gtg?gtg?acc?aag?gat?att?ccg?gat?gat?tct?att?gct?gtg?ggc?aac?cct 643

Val?Val?Thr?Lys?Asp?Ile?Pro?Asp?Asp?Ser?Ile?Ala?Val?Gly?Asn?Pro

170 175 180

gcg?cga?gta?gtg?cgg?aaa?cgt?gat?gat?agc?cgg?ctc?gaa?cgt?tcg?cag 691

Ala?Arg?Val?Val?Arg?Lys?Arg?Asp?Asp?Ser?Arg?Leu?Glu?Arg?Ser?Gln

185 190 195

ctg?cca?gaa?ggt?gct?tcc?gtg?gat?gcg?ttg?ggg?att?ctt?cct?aca?aaa 739

Leu?Pro?Glu?Gly?Ala?Ser?Val?Asp?Ala?Leu?Gly?Ile?Leu?Pro?Thr?Lys

200 205 210

tca?cct?agg?ctg?tca?gaa?aat?att?gcc?gaa?aaa?tat?taaatacgca 785

Ser?Pro?Arg?Leu?Ser?Glu?Asn?Ile?Ala?Glu?Lys?Tyr

215 220 225

ggcactaaga?aga 798

<210>436

<211>225

<212>PRT

＜213〉Corynebacterium glutamicum

<400>436

Met?Asp?Asn?Asp?Phe?Glu?Ser?Ile?Glu?Lys?Met?Ser?Ser?Gly?Asp?Trp

1 5 10 15

Tyr?Val?Ala?Thr?Gly?Ala?Glu?Arg?Glu?Glu?Val?Ala?Gln?Lys?Thr?Ala

20 25 30

Leu?Leu?Phe?His?Glu?Tyr?Asn?Gln?Ile?Gly?Pro?Thr?Asp?Pro?Ala?Arg

35 40 45

Thr?Ala?Glu?Ile?Leu?Arg?Thr?Val?Leu?Asn?Pro?Ala?Ser?Gly?Thr?Cys

50 55 60

Thr?Ile?Lys?Ala?Pro?Ala?Ile?Ile?Glu?Tyr?Gly?Phe?Asn?Thr?Thr?Ile

65 70 75 80

Gly?Glu?His?Val?Phe?Ile?Asn?Phe?Gly?Leu?Thr?Ile?Leu?Asp?Ile?Ala

85 90 95

Pro?Val?Arg?Ile?Gly?Ala?Arg?Ser?Met?Leu?Gly?Pro?Asn?Cys?Gln?Leu

100 105 110

Phe?Thr?Ala?Gly?His?Pro?Val?Asp?Asp?Trp?Glu?Met?Arg?Ser?Gly?Gly

115 120 125

Trp?Glu?Asn?Gly?Ala?Pro?Ile?Ser?Ile?Gly?Glu?Asp?Thr?Trp?Leu?Gly

130 135 140

Gly?Asn?Val?Thr?Val?Val?Gly?Gly?Val?Ser?Ile?Gly?Asp?Arg?Cys?Val

145 150 155 160

Ile?Gly?Ala?Gly?Pro?Val?Val?Thr?Lys?Asp?Ile?Pro?Asp?Asp?Ser?Ile

165 170 175

Ala?Val?Gly?Asn?Pro?Ala?Arg?Val?Val?Arg?Lys?Arg?Asp?Asp?Ser?Arg

180 185 190

Leu?Glu?Arg?Ser?Gln?Leu?Pro?Glu?Gly?Ala?Ser?Val?Asp?Ala?Leu?Gly

195 200 205

Ile?Leu?Pro?Thr?Lys?Ser?Pro?Arg?Leu?Ser?Glu?Asn?Ile?Ala?Glu?Lys

210 215 220

Tyr

225

<210>437

<211>891

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(868)

<223>RXA02666

<400>437

gctcggcgac?gaggaagaga?agaaggacgc?attcgacgac?ttcgacgatt?ccgacgtgga?60

tcttgacgat?ctgagcttcg?acgacgaaga?ttagacgccc?atg?tcg?tct?aca?cga 115

Met?Ser?Ser?Thr?Arg

1 5

atc?ccc?gtc?atc?gca?ctc?ctc?gcg?gcg?gcg?ggg?cgc?gga?acc?cgc?ctc 163

Ile?Pro?Val?Ile?Ala?Leu?Leu?Ala?Ala?Ala?Gly?Arg?Gly?Thr?Arg?Leu

10 15 20

ggc?gga?ccc?atc?ccc?aaa?gca?ttc?gtc?acg?ttg?cgt?gaa?cgc?aca?ctt 211

Gly?Gly?Pro?Ile?Pro?Lys?Ala?Phe?Val?Thr?Leu?Arg?Glu?Arg?Thr?Leu

25 30 35

tta?gag?cgc?tcg?ctc?caa?gcc?atg?ctc?acc?tcc?gaa?agc?gtc?gac?gaa 259

Leu?Glu?Arg?Ser?Leu?Gln?Ala?Met?Leu?Thr?Ser?Glu?Ser?Val?Asp?Glu

40 45 50

atc?atc?atc?ctc?gtc?agc?ccc?gac?atg?gaa?acc?tac?gcc?cgc?gat?ttg 307

Ile?Ile?Ile?Leu?Val?Ser?Pro?Asp?Met?Glu?Thr?Tyr?Ala?Arg?Asp?Leu

55 60 65

ctg?cgc?aaa?cgc?ggt?ctt?ttg?aac?gac?ccc?gaa?ggg?gta?cgc?gta?cgg 355

Leu?Arg?Lys?Arg?Gly?Leu?Leu?Asn?Asp?Pro?Glu?Gly?Val?Arg?Val?Arg

70 75 80 85

ctc?gtg?cac?ggc?ggc?ggg?gag?cgc?gcg?gac?tcg?gtc?tgg?gca?ggc?ctt 403

Leu?Val?His?Gly?Gly?Gly?Glu?Arg?Ala?Asp?Ser?Val?Trp?Ala?Gly?Leu

90 95 100

cag?gca?att?tcg?ctt?gac?gac?gcc?acc?ccc?gat?gca?att?gtc?tta?atc 451

Gln?Ala?Ile?Ser?Leu?Asp?Asp?Ala?Thr?Pro?Asp?Ala?Ile?Val?Leu?Ile

105 110 115

cac?gac?agc?gcc?cga?gcg?ctc?aca?cca?ccc?ggc?atg?att?gcg?cgc?gtg 499

His?Asp?Ser?Ala?Arg?Ala?Leu?Thr?Pro?Pro?Gly?Met?Ile?Ala?Arg?Val

120 125 130

gtg?cgc?aaa?gtc?cac?gaa?ggc?gcc?acc?gca?gtc?atc?cca?gta?ctg?cca 547

Val?Arg?Lys?Val?His?Glu?Gly?Ala?Thr?Ala?Val?Ile?Pro?Val?Leu?Pro

135 140 145

gta?tcg?gac?acc?atc?aaa?cga?gtg?tcc?cct?gat?ggc?gga?gta?gtt?gtc 595

Val?Ser?Asp?Thr?Ile?Lys?Arg?Val?Ser?Pro?Asp?Gly?Gly?Val?Val?Val

150 155 160 165

gac?aca?ccc?aac?cgt?gca?gaa?ctt?cgc?gcc?gtc?caa?acc?cca?caa?ggc 643

Asp?Thr?Pro?Asn?Arg?Ala?Glu?Leu?Arg?Ala?Val?Gln?Thr?Pro?Gln?Gly

170 175 180

ttc?ctg?ctg?tcc?gaa?ctt?gtt?gca?gcg?aat?gag?aaa?ttc?ttc?gcc?gac 691

Phe?Leu?Leu?Ser?Glu?Leu?Val?Ala?Ala?Asn?Glu?Lys?Phe?Phe?Ala?Asp

185 190 195

ccc?aac?cca?ggc?ttc?atc?cca?acc?gat?gac?gcc?agc?ttg?atg?gaa?tgg 739

Pro?Asn?Pro?Gly?Phe?Ile?Pro?Thr?Asp?Asp?Ala?Ser?Leu?Met?Glu?Trp

200 205 210

tac?ggc?gca?gat?gta?gtc?tgc?gta?caa?ggc?gac?cca?atg?gcg?ttt?aaa 787

Tyr?Gly?Ala?Asp?Val?Val?Cys?Val?Gln?Gly?Asp?Pro?Met?Ala?Phe?Lys

215 220 225

gta?aca?acc?ccc?att?gat?atg?atg?ctg?gca?caa?cgc?atc?acc?gac?gaa 835

Val?Thr?Thr?Pro?Ile?Asp?Met?Met?Leu?Ala?Gln?Arg?Ile?Thr?Asp?Glu

230 235 240 245

gcc?gaa?ccc?aca?ata?ttt?gag?gta?cca?ggt?gac?taacccaatc?atcccccgcg?888

Ala?Glu?Pro?Thr?Ile?Phe?Glu?Val?Pro?Gly?Asp

250 255

tag 891

<210>438

<211>256

<212>PRT

＜213〉Corynebacterium glutamicum

<400>438

Met?Ser?Ser?Thr?Arg?Ile?Pro?Val?Ile?Ala?Leu?Leu?Ala?Ala?Ala?Gly

1 5 10 15

Arg?Gly?Thr?Arg?Leu?Gly?Gly?Pro?Ile?Pro?Lys?Ala?Phe?Val?Thr?Leu

20 25 30

Arg?Glu?Arg?Thr?Leu?Leu?Glu?Arg?Ser?Leu?Gln?Ala?Met?Leu?Thr?Ser

35 40 45

Glu?Ser?Val?Asp?Glu?Ile?Ile?Ile?Leu?Val?Ser?Pro?Asp?Met?Glu?Thr

50 55 60

Tyr?Ala?Arg?Asp?Leu?Leu?Arg?Lys?Arg?Gly?Leu?Leu?Asn?Asp?Pro?Glu

65 70 75 80

Gly?Val?Arg?Val?Arg?Leu?Val?His?Gly?Gly?Gly?Glu?Arg?Ala?Asp?Ser

85 90 95

Val?Trp?Ala?Gly?Leu?Gln?Ala?Ile?Ser?Leu?Asp?Asp?Ala?Thr?Pro?Asp

100 105 110

Ala?Ile?Val?Leu?Ile?His?Asp?Ser?Ala?Arg?Ala?Leu?Thr?Pro?Pro?Gly

115 120 125

Met?Ile?Ala?Arg?Val?Val?Arg?Lys?Val?His?Glu?Gly?Ala?Thr?Ala?Val

130 135 140

Ile?Pro?Val?Leu?Pro?Val?Ser?Asp?Thr?Ile?Lys?Arg?Val?Ser?Pro?Asp

145 150 155 160

Gly?Gly?Val?Val?Val?Asp?Thr?Pro?Asn?Arg?Ala?Glu?Leu?Arg?Ala?Val

165 170 175

Gln?Thr?Pro?Gln?Gly?Phe?Leu?Leu?Ser?Glu?Leu?Val?Ala?Ala?Asn?Glu

180 185 190

Lys?Phe?Phe?Ala?Asp?Pro?Asn?Pro?Gly?Phe?Ile?Pro?Thr?Asp?Asp?Ala

195 200 205

Ser?Leu?Met?Glu?Trp?Tyr?Gly?Ala?Asp?Val?Val?Cys?Val?Gln?Gly?Asp

210 215 220

Pro?Met?Ala?Phe?Lys?Val?Thr?Thr?Pro?Ile?Asp?Met?Met?Leu?Ala?Gln

225 230 235 240

Arg?Ile?Thr?Asp?Glu?Ala?Glu?Pro?Thr?Ile?Phe?Glu?Val?Pro?Gly?Asp

245 250 255

<210>439

<211>1065

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1042)

<223>RXA00202

<400>439

ctggcagcag?attgtcatcg?gttgtgtcat?cgcgcttgcg?gtgggcttcg?atgtcatccg?60

aaacaaaacc?tctaagtaat?tcctgaaagg?aaattttcac?atg?tac?gct?cgt?aaa 115

Met?Tyr?Ala?Arg?Lys

1 5

ctt?att?gct?ctg?tcc?gct?tct?gtc?gtt?ttg?gct?ttc?agc?ttg?tct?gct 163

Leu?Ile?Ala?Leu?Ser?Ala?Ser?Val?Val?Leu?Ala?Phe?Ser?Leu?Ser?Ala

10 15 20

tgc?aac?cgt?gaa?tct?tct?ggc?acc?agc?gca?gac?ggc?ggt?tct?gcg?gat 211

Cys?Asn?Arg?Glu?Ser?Ser?Gly?Thr?Ser?Ala?Asp?Gly?Gly?Ser?Ala?Asp

25 30 35

ggg?tcg?atc?acc?ttg?gct?ctg?tct?acc?cag?acc?aac?ccg?ttc?ttt?gtg 259

Gly?Ser?Ile?Thr?Leu?Ala?Leu?Ser?Thr?Gln?Thr?Asn?Pro?Phe?Phe?Val

40 45 50

cag?ctt?cgt?gat?ggt?gcc?cag?gaa?aag?gct?gat?gaa?ttg?ggc?gtg?acc 307

Gln?Leu?Arg?Asp?Gly?Ala?Gln?Glu?Lys?Ala?Asp?Glu?Leu?Gly?Val?Thr

55 60 65

ctc?aat?gtt?cag?gat?gct?tcc?gat?gac?gct?gca?acg?cag?gcc?aac?cag 355

Leu?Asn?Val?Gln?Asp?Ala?Ser?Asp?Asp?Ala?Ala?Thr?Gln?Ala?Asn?Gln

70 75 80 85

ctc?aac?aac?gct?gtc?acc?acc?ggt?gct?ggc?gtg?gtg?att?gtc?aac?cca 403

Leu?Asn?Asn?Ala?Val?Thr?Thr?Gly?Ala?Gly?Val?Val?Ile?Val?Asn?Pro

90 95 100

act?gat?tct?gat?gct?gtg?gtg?ccg?tcg?gtg?gaa?gct?ctc?aac?cag?gct 451

Thr?Asp?Ser?Asp?Ala?Val?Val?Pro?Ser?Val?Glu?Ala?Leu?Asn?Gln?Ala

105 110 115

gac?att?cct?gtt?gtg?gct?gtc?gac?cgt?tcc?tcc?aat?ggt?ggc?gag?gtg 499

Asp?Ile?Pro?Val?Val?Ala?Val?Asp?Arg?Ser?Ser?Asn?Gly?Gly?Glu?Val

120 125 130

gcg?tcc?ttc?gtg?gca?tct?gac?aac?gtt?gct?ggc?ggc?gcg?cag?gct?gct 547

Ala?Ser?Phe?Val?Ala?Ser?Asp?Asn?Val?Ala?Gly?Gly?Ala?Gln?Ala?Ala

135 140 145

gca?gcc?ctg?gca?gag?gcg?atc?ggt?ggc?gaa?ggt?gaa?atc?ctc?atg?ctg 595

Ala?Ala?Leu?Ala?Glu?Ala?Ile?Gly?Gly?Glu?Gly?Glu?Ile?Leu?Met?Leu

150 155 160 165

caa?ggc?att?gcg?gga?tcc?tct?gca?tca?cgt?gat?cgt?gga?cag?gga?ttt 643

Gln?Gly?Ile?Ala?Gly?Ser?Ser?Ala?Ser?Arg?Asp?Arg?Gly?Gln?Gly?Phe

170 175 180

gaa?gag?gag?atc?gct?aag?cat?gag?ggc?att?tcc?att?gtg?gct?aag?cag 691

Glu?Glu?Glu?Ile?Ala?Lys?His?Glu?Gly?Ile?Ser?Ile?Val?Ala?Lys?Gln

185 190 195

acc?gcc?aac?ttt?gac?cgc?ggt?gag?ggc?ctg?gac?gtg?gca?act?aac?ctg 739

Thr?Ala?Asn?Phe?Asp?Arg?Gly?Glu?Gly?Leu?Asp?Val?Ala?Thr?Asn?Leu

200 205 210

ctg?cag?gca?cac?ccc?aat?gtg?aag?gcg?atc?ttc?gcg?gaa?aac?gat?gag 787

Leu?Gln?Ala?His?Pro?Asn?Val?Lys?Ala?Ile?Phe?Ala?Glu?Asn?Asp?Glu

215 220 225

atg?gcg?ttg?ggc?gca?atc?gaa?gcc?ctg?ggt?gct?cgt?gct?ggt?gaa?gat 835

Met?Ala?Leu?Gly?Ala?Ile?Glu?Ala?Leu?Gly?Ala?Arg?Ala?Gly?Glu?Asp

230 235 240 245

gtc?atc?gtt?gtc?ggt?ttc?gat?ggc?acc?aat?gat?ggt?ctg?gca?gcg?gtt 883

Val?Ile?Val?Val?Gly?Phe?Asp?Gly?Thr?Asn?Asp?Gly?Leu?Ala?Ala?Val

250 255 260

gaa?gat?gga?cgc?atg?ttg?gcc?acc?gtt?gct?cag?cag?cca?gaa?gag?ctg 931

Glu?Asp?Gly?Arg?Met?Leu?Ala?Thr?Val?Ala?Gln?Gln?Pro?Glu?Glu?Leu

265 270 275

gga?gca?aag?gct?gtg?gaa?gaa?gca?gct?aag?ctc?ctg?cgc?ggt?gag?gac 979

Gly?Ala?Lys?Ala?Val?Glu?Glu?Ala?Ala?Lys?Leu?Leu?Arg?Gly?Glu?Asp

280 285 290

gct?gaa?aca?gag?gta?cca?gtt?gag?gtt?gtc?act?gtg?aag?ctc?gac?aac 1027

Ala?Glu?Thr?Glu?Val?Pro?Val?Glu?Val?Val?Thr?Val?Lys?Leu?Asp?Asn

295 300 305

gtc?gcg?gac?ttc?aag?tagtcggcga?tgaaaaagtc?cgt 1065

Val?Ala?Asp?Phe?Lys

310

<210>440

<211>314

<212>PRT

＜213〉Corynebacterium glutamicum

<400>440

Met?Tyr?Ala?Arg?Lys?Leu?Ile?Ala?Leu?Ser?Ala?Ser?Val?Val?Leu?Ala

1 5 10 15

Phe?Ser?Leu?Ser?Ala?Cys?Asn?Arg?Glu?Ser?Ser?Gly?Thr?Ser?Ala?Asp

20 25 30

Gly?Gly?Ser?Ala?Asp?Gly?Ser?Ile?Thr?Leu?Ala?Leu?Ser?Thr?Gln?Thr

35 40 45

Asn?Pro?Phe?Phe?Val?Gln?Leu?Arg?Asp?Gly?Ala?Gln?Glu?Lys?Ala?Asp

50 55 60

Glu?Leu?Gly?Val?Thr?Leu?Asn?Val?Gln?Asp?Ala?Ser?Asp?Asp?Ala?Ala

65 70 75 80

Thr?Gln?Ala?Asn?Gln?Leu?Asn?Asn?Ala?Val?Thr?Thr?Gly?Ala?Gly?Val

85 90 95

Val?Ile?Val?Asn?Pro?Thr?Asp?Ser?Asp?Ala?Val?Val?Pro?Ser?Val?Glu

100 105 110

Ala?Leu?Asn?Gln?Ala?Asp?Ile?Pro?Val?Val?Ala?Val?Asp?Arg?Ser?Ser

115 120 125

Asn?Gly?Gly?Glu?Val?Ala?Ser?Phe?Val?Ala?Ser?Asp?Asn?Val?Ala?Gly

130 135 140

Gly?Ala?Gln?Ala?Ala?Ala?Ala?Leu?Ala?Glu?Ala?Ile?Gly?Gly?Glu?Gly

145 150 155 160

Glu?Ile?Leu?Met?Leu?Gln?Gly?Ile?Ala?Gly?Ser?Ser?Ala?Ser?Arg?Asp

165 170 175

Arg?Gly?Gln?Gly?Phe?Glu?Glu?Glu?Ile?Ala?Lys?His?Glu?Gly?Ile?Ser

180 185 190

Ile?Val?Ala?Lys?Gln?Thr?Ala?Asn?Phe?Asp?Arg?Gly?Glu?Gly?Leu?Asp

195 200 205

Val?Ala?Thr?Asn?Leu?Leu?Gln?Ala?His?Pro?Asn?Val?Lys?Ala?Ile?Phe

210 215 220

Ala?Glu?Asn?Asp?Glu?Met?Ala?Leu?Gly?Ala?Ile?Glu?Ala?Leu?Gly?Ala

225 230 235 240

Arg?Ala?Gly?Glu?Asp?Val?Ile?Val?Val?Gly?Phe?Asp?Gly?Thr?Asn?Asp

245 250 255

Gly?Leu?Ala?Ala?Val?Glu?Asp?Gly?Arg?Met?Leu?Ala?Thr?Val?Ala?Gln

260 265 270

Gln?Pro?Glu?Glu?Leu?Gly?Ala?Lys?Ala?Val?Glu?Glu?Ala?Ala?Lys?Leu

275 280 285

Leu?Arg?Gly?Glu?Asp?Ala?Glu?Thr?Glu?Val?Pro?Val?Glu?Val?Val?Thr

290 295 300

Val?Lys?Leu?Asp?Asn?Val?Ala?Asp?Phe?Lys

305 310

<210>441

<211>963

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(940)

<223>RXA02440

<400>441

gctgttaatc?acgggttgtt?cagctaccgg?gggagcacca?cgggcaacag?atggggcatc?60

aggcggagga?accgtcgata?cgcctcggtt?ggttgtcgcg?atg?gtg?agc?cac?ggc 115

Met?Val?Ser?His?Gly

1 5

gcg?ccg?ggc?gat?act?ttt?tgg?gat?ttg?gtc?cga?aaa?ggt?gct?gaa?gac 163

Ala?Pro?Gly?Asp?Thr?Phe?Trp?Asp?Leu?Val?Arg?Lys?Gly?Ala?Glu?Asp

10 15 20

gcc?gcc?caa?aaa?gac?aac?gtt?gaa?ctc?cgc?tat?tcc?tct?aat?ccg?gaa 211

Ala?Ala?Gln?Lys?Asp?Asn?Val?Glu?Leu?Arg?Tyr?Ser?Ser?Asn?Pro?Glu

25 30 35

atc?cct?gaa?caa?tcc?aac?ctc?gtg?caa?aat?gcc?atc?gat?tca?cgc?gtc 259

Ile?Pro?Glu?Gln?Ser?Asn?Leu?Val?Gln?Asn?Ala?Ile?Asp?Ser?Arg?Val

40 45 50

gac?ggc?atc?gcc?atg?acc?atg?cct?aat?gct?caa?tca?cta?gga?ccg?gtc 307

Asp?Gly?Ile?Ala?Met?Thr?Met?Pro?Asn?Ala?Gln?Ser?Leu?Gly?Pro?Val

55 60 65

gct?caa?aag?gcc?gtg?gat?gcg?ggc?att?cct?gtg?gtt?ggt?ctc?aac?gct 355

Ala?Gln?Lys?Ala?Val?Asp?Ala?Gly?Ile?Pro?Val?Val?Gly?Leu?Asn?Ala

70 75 80 85

gga?atg?aac?gaa?tac?caa?gat?tat?gga?atg?aca?gga?ttc?ttt?ggt?caa 403

Gly?Met?Asn?Glu?Tyr?Gln?Asp?Tyr?Gly?Met?Thr?Gly?Phe?Phe?Gly?Gln

90 95 100

gat?gaa?tcc?gtc?gca?gga?gca?tcc?gca?gga?gcg?cgc?ctt?gcc?gag?gaa 451

Asp?Glu?Ser?Val?Ala?Gly?Ala?Ser?Ala?Gly?Ala?Arg?Leu?Ala?Glu?Glu

105 110 115

aac?gca?caa?aaa?gtt?ttg?tgt?gtg?atc?cat?gaa?cag?ggc?aac?tcc?tcc 499

Asn?Ala?Gln?Lys?Val?Leu?Cys?Val?Ile?His?Glu?Gln?Gly?Asn?Ser?Ser

120 125 130

cag?gaa?gct?cgc?tgt?ggt?ggc?gtg?tct?gaa?ggt?ttg?ggc?aaa?caa?gta 547

Gln?Glu?Ala?Arg?Cys?Gly?Gly?Val?Ser?Glu?Gly?Leu?Gly?Lys?Gln?Val

135 140 145

gaa?acc?ctg?tat?gtc?aac?ggc?atg?gat?ctc?acc?tca?gtg?aac?tcc?acc 595

Glu?Thr?Leu?Tyr?Val?Asn?Gly?Met?Asp?Leu?Thr?Ser?Val?Asn?Ser?Thr

150 155 160 165

ctg?cag?gca?aaa?ctt?gct?caa?gac?cgc?agc?att?gat?tgg?gtt?gtg?gga 643

Leu?Gln?Ala?Lys?Leu?Ala?Gln?Asp?Arg?Ser?Ile?Asp?Trp?Val?Val?Gly

170 175 180

ctc?cag?gct?ggt?gta?tca?atg?gct?att?tct?gat?gcg?gca?gac?gct?gcg 691

Leu?Gln?Ala?Gly?Val?Ser?Met?Ala?Ile?Ser?Asp?Ala?Ala?Asp?Ala?Ala

185 190 195

aac?tca?gaa?gta?aag?atc?gcc?acc?ttt?gat?aca?aac?gca?cag?ctc?atg 739

Asn?Ser?Glu?Val?Lys?Ile?Ala?Thr?Phe?Asp?Thr?Asn?Ala?Gln?Leu?Met

200 205 210

acc?gct?att?cgt?gat?ggc?aag?atc?caa?ttc?gcc?att?gat?cag?caa?cca 787

Thr?Ala?Ile?Arg?Asp?Gly?Lys?Ile?Gln?Phe?Ala?Ile?Asp?Gln?Gln?Pro

215 220 225

tat?ctg?cag?ggc?tac?atg?gcc?gtg?gat?tcg?ctg?tgg?ttg?gcg?cac?cga 835

Tyr?Leu?Gln?Gly?Tyr?Met?Ala?Val?Asp?Ser?Leu?Trp?Leu?Ala?His?Arg

230 235 240 245

aac?ggc?acc?act?gtt?ggt?ggc?gga?cga?ccc?gtg?tac?aca?gga?cca?gcc 883

Asn?Gly?Thr?Thr?Val?Gly?Gly?Gly?Arg?Pro?Val?Tyr?Thr?Gly?Pro?Ala

250 255 260

att?gtg?gat?gcc?acc?aac?gtt?gat?gtc?att?gct?gaa?gcc?gtt?ggg?gag 931

Ile?Val?Asp?Ala?Thr?Asn?Val?Asp?Val?Ile?Ala?Glu?Ala?Val?Gly?Glu

265 270 275

ggt?ctg?cga?tgacaaaaat?caagagtggg?gag 963

Gly?Leu?Arg

280

<210>442

<211>280

<212>PRT

＜213〉Corynebacterium glutamicum

<400>442

Met?Val?Ser?His?Gly?Ala?Pro?Gly?Asp?Thr?Phe?Trp?Asp?Leu?Val?Arg

1 5 10 15

Lys?Gly?Ala?Glu?Asp?Ala?Ala?Gln?Lys?Asp?Asn?Val?Glu?Leu?Arg?Tyr

20 25 30

Ser?Ser?Asn?Pro?Glu?Ile?Pro?Glu?Gln?Ser?Asn?Leu?Val?Gln?Asn?Ala

35 40 45

Ile?Asp?Ser?Arg?Val?Asp?Gly?Ile?Ala?Met?Thr?Met?Pro?Asn?Ala?Gln

50 55 60

Ser?Leu?Gly?Pro?Val?Ala?Gln?Lys?Ala?Val?Asp?Ala?Gly?Ile?Pro?Val

65 70 75 80

Val?Gly?Leu?Asn?Ala?Gly?Met?Asn?Glu?Tyr?Gln?Asp?Tyr?Gly?Met?Thr

85 90 95

Gly?Phe?Phe?Gly?Gln?Asp?Glu?Ser?Val?Ala?Gly?Ala?Ser?Ala?Gly?Ala

100 105 110

Arg?Leu?Ala?Glu?Glu?Asn?Ala?Gln?Lys?Val?Leu?Cys?Val?Ile?His?Glu

115 120 125

Gln?Gly?Asn?Ser?Ser?Gln?Glu?Ala?Arg?Cys?Gly?Gly?Val?Ser?Glu?Gly

130 135 140

Leu?Gly?Lys?Gln?Val?Glu?Thr?Leu?Tyr?Val?Asn?Gly?Met?Asp?Leu?Thr

145 150 155 160

Ser?Val?Asn?Ser?Thr?Leu?Gln?Ala?Lys?Leu?Ala?Gln?Asp?Arg?Ser?Ile

165 170 175

Asp?Trp?Val?Val?Gly?Leu?Gln?Ala?Gly?Val?Ser?Met?Ala?Ile?Ser?Asp

180 185 190

Ala?Ala?Asp?Ala?Ala?Asn?Ser?Glu?Val?Lys?Ile?Ala?Thr?Phe?Asp?Thr

195 200 205

Asn?Ala?Gln?Leu?Met?Thr?Ala?Ile?Arg?Asp?Gly?Lys?Ile?Gln?Phe?Ala

210 215 220

Ile?Asp?Gln?Gln?Pro?Tyr?Leu?Gln?Gly?Tyr?Met?Ala?Val?Asp?Ser?Leu

225 230 235 240

Trp?Leu?Ala?His?Arg?Asn?Gly?Thr?Thr?Val?Gly?Gly?Gly?Arg?Pro?Val

245 250 255

Tyr?Thr?Gly?Pro?Ala?Ile?Val?Asp?Ala?Thr?Asn?Val?Asp?Val?Ile?Ala

260 265 270

Glu?Ala?Val?Gly?Glu?Gly?Leu?Arg

275 280

<210>443

<211>1482

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1459)

<223>RXN01569

<400>443

aaggcctaga?gcagaccatc?gattggtacc?gcgaaaacga?ggcctggtgg?cgccctgcca?60

agaacaacgt?cgaagctacc?tacgctaagc?agggacaata?atg?gaa?tac?ggt?aaa 115

Met?Glu?Tyr?Gly?Lys

1 5

caa?ctc?acc?tcc?cac?acc?acc?gac?atc?gaa?ggc?cta?ctg?gtt?ttc?gat 163

Gln?Leu?Thr?Ser?His?Thr?Thr?Asp?Ile?Glu?Gly?Leu?Leu?Val?Phe?Asp

10 15 20

ttc?ccc?gtc?cac?ggc?gac?aac?cgc?ggc?tgg?ttc?aag?gaa?aat?tgg?cag 211

Phe?Pro?Val?His?Gly?Asp?Asn?Arg?Gly?Trp?Phe?Lys?Glu?Asn?Trp?Gln

25 30 35

cgc?acc?aag?atg?acc?aac?ctg?ggg?ctg?ccc?gat?ttt?ggc?ccc?gtc?caa 259

Arg?Thr?Lys?Met?Thr?Asn?Leu?Gly?Leu?Pro?Asp?Phe?Gly?Pro?Val?Gln

40 45 50

aac?aac?atg?agt?ttc?aac?gcc?acc?gcc?ggc?acg?act?cgc?ggc?atg?cac 307

Asn?Asn?Met?Ser?Phe?Asn?Ala?Thr?Ala?Gly?Thr?Thr?Arg?Gly?Met?His

55 60 65

gct?gag?ccg?tgg?gat?aaa?ttt?gtg?tcc?gtc?gcg?gtg?ggt?tcc?gtt?ttc 355

Ala?Glu?Pro?Trp?Asp?Lys?Phe?Val?Ser?Val?Ala?Val?Gly?Ser?Val?Phe

70 75 80 85

gga?gct?tgg?gtg?gat?ctg?cgc?gcg?ggc?tcg?agc?acg?tac?ggt?aac?gtc 403

Gly?Ala?Trp?Val?Asp?Leu?Arg?Ala?Gly?Ser?Ser?Thr?Tyr?Gly?Asn?Val

90 95 100

gta?acg?caa?aaa?att?acc?cct?gac?gtg?gga?gtt?tac?gtc?ccg?cgt?ggt 451

Val?Thr?Gln?Lys?Ile?Thr?Pro?Asp?Val?Gly?Val?Tyr?Val?Pro?Arg?Gly

105 110 115

gtg?gca?aac?ggc?ttc?cag?gcg?ctc?gag?gac?ggc?acg?ctg?tac?acc?tac 499

Val?Ala?Asn?Gly?Phe?Gln?Ala?Leu?Glu?Asp?Gly?Thr?Leu?Tyr?Thr?Tyr

120 125 130

ctc?gtc?aac?gat?cat?tgg?tcc?ccc?gac?gcg?cat?tac?gcc?aac?gtc?aac 547

Leu?Val?Asn?Asp?His?Trp?Ser?Pro?Asp?Ala?His?Tyr?Ala?Asn?Val?Asn

135 140 145

ctc?aac?atg?atc?gac?tgg?ccg?ctg?ccc?atc?acc?gag?atc?tcc?gaa?aaa 595

Leu?Asn?Met?Ile?Asp?Trp?Pro?Leu?Pro?Ile?Thr?Glu?Ile?Ser?Glu?Lys

150 155 160 165

gat?aaa?aaa?cat?cca?gcg?ctt?atc?gac?gcc?acc?ccc?ctg?ccc?gcc?cgc 643

Asp?Lys?Lys?His?Pro?Ala?Leu?Ile?Asp?Ala?Thr?Pro?Leu?Pro?Ala?Arg

170 175 180

aag?gtt?ctc?gtg?gtc?ggc?gcc?ggc?gga?caa?ctg?gga?acc?gcg?cta?cgc 691

Lys?Val?Leu?Val?Val?Gly?Ala?Gly?Gly?Gln?Leu?Gly?Thr?Ala?Leu?Arg

185 190 195

gcg?cag?ttc?cca?gac?gcg?gaa?ttt?gtc?acg?cgc?caa?gaa?ctc?gat?atc 739

Ala?Gln?Phe?Pro?Asp?Ala?Glu?Phe?Val?Thr?Arg?Gln?Glu?Leu?Asp?Ile

200 205 210

acc?tca?gat?ctc?acc?gag?gct?cgc?gcg?tgg?aaa?caa?tac?tcc?acc?atc 787

Thr?Ser?Asp?Leu?Thr?Glu?Ala?Arg?Ala?Trp?Lys?Gln?Tyr?Ser?Thr?Ile

215 220 225

ata?aac?gcc?gcc?gcc?tac?act?gcc?gtt?gac?cag?gca?gaa?cac?gac?cgc 835

Ile?Asn?Ala?Ala?Ala?Tyr?Thr?Ala?Val?Asp?Gln?Ala?Glu?His?Asp?Arg

230 235 240 245

gca?gca?gcg?tgg?gac?atc?aac?gca?gcg?gca?gtg?gct?aac?ctc?gcg?acc 883

Ala?Ala?Ala?Trp?Asp?Ile?Asn?Ala?Ala?Ala?Val?Ala?Asn?Leu?Ala?Thr

250 255 260

atc?gcg?cgc?gac?aac?aac?ctc?acc?ctc?gtg?cac?gtg?tcc?tca?gat?tat 931

Ile?Ala?Arg?Asp?Asn?Asn?Leu?Thr?Leu?Val?His?Val?Ser?Ser?Asp?Tyr

265 270 275

gtc?ttc?gac?ggt?gcg?gcc?gaa?tcc?tac?gat?gaa?aac?gca?ccg?ttt?tcc 979

Val?Phe?Asp?Gly?Ala?Ala?Glu?Ser?Tyr?Asp?Glu?Asn?Ala?Pro?Phe?Ser

280 285 290

cca?ctc?ggc?gtg?tac?ggc?caa?tcc?aaa?gca?gcc?ggc?gac?atc?gga?gac 1027

Pro?Leu?Gly?Val?Tyr?Gly?Gln?Ser?Lys?Ala?Ala?Gly?Asp?Ile?Gly?Asp

295 300 305

acc?acc?gca?ccg?cgc?cac?tac?att?gtg?cgc?acc?agc?tgg?gtg?att?ggc 1075

Thr?Thr?Ala?Pro?Arg?His?Tyr?Ile?Val?Arg?Thr?Ser?Trp?Val?Ile?Gly

310 315 320 325

gat?ggc?aat?aat?ttt?gtc?cgc?acc?atg?aaa?tcc?ctc?gac?gaa?cgc?ggc 1123

Asp?Gly?Asn?Asn?Phe?Val?Arg?Thr?Met?Lys?Ser?Leu?Asp?Glu?Arg?Gly

330 335 340

atc?gca?cca?tca?gta?gtt?gat?gat?caa?atc?ggc?cgc?cta?tcc?ttc?acc 1171

Ile?Ala?Pro?Ser?Val?Val?Asp?Asp?Gln?Ile?Gly?Arg?Leu?Ser?Phe?Thr

345 350 355

gaa?gac?atc?gca?gcc?ggc?atc?gcg?cac?ctt?ttg?gaa?gtg?ggt?gca?gca 1219

Glu?Asp?Ile?Ala?Ala?Gly?Ile?Ala?His?Leu?Leu?Glu?Val?Gly?Ala?Ala

360 365 370

tat?ggc?acc?tac?aac?ctc?acc?aac?acc?ggc?gaa?ccc?gca?agc?tgg?gcc 1267

Tyr?Gly?Thr?Tyr?Asn?Leu?Thr?Asn?Thr?Gly?Glu?Pro?Ala?Ser?Trp?Ala

375 380 385

gat?gtt?gcc?cgc?gca?gta?ttt?tcc?gac?ccc?acc?aaa?gtt?acc?ggc?gtg 1315

Asp?Val?Ala?Arg?Ala?Val?Phe?Ser?Asp?Pro?Thr?Lys?Val?Thr?Gly?Val

390 395 400 405

agc?acc?gcc?gag?tac?ttc?gcc?aac?aaa?gac?gca?gcg?ccc?cgc?cca?ctg 1363

Ser?Thr?Ala?Glu?Tyr?Phe?Ala?Asn?Lys?Asp?Ala?Ala?Pro?Arg?Pro?Leu

410 415 420

aac?tcc?gtt?ttg?gat?ctc?ggc?aaa?atc?gaa?gcc?acc?gga?ttt?agc?gca 1411

Asn?Ser?Val?Leu?Asp?Leu?Gly?Lys?Ile?Glu?Ala?Thr?Gly?Phe?Ser?Ala

425 430 435

ccg?acc?tgg?cag?acc?cgc?ctc?aac?gac?tac?ctc?aag?gaa?ctc?tca?aag 1459

Pro?Thr?Trp?Gln?Thr?Arg?Leu?Asn?Asp?Tyr?Leu?Lys?Glu?Leu?Ser?Lys

440 445 450

tgaaaggcat?catcctcgca?ggt 1482

<210>444

<211>453

<212>PRT

＜213〉Corynebacterium glutamicum

<400>444

Met?Glu?Tyr?Gly?Lys?Gln?Leu?Thr?Ser?His?Thr?Thr?Asp?Ile?Glu?Gly

1 5 10 15

Leu?Leu?Val?Phe?Asp?Phe?Pro?Val?His?Gly?Asp?Asn?Arg?Gly?Trp?Phe

20 25 30

Lys?Glu?Asn?Trp?Gln?Arg?Thr?Lys?Met?Thr?Asn?Leu?Gly?Leu?Pro?Asp

35 40 45

Phe?Gly?Pro?Val?Gln?Asn?Asn?Met?Ser?Phe?Asn?Ala?Thr?Ala?Gly?Thr

50 55 60

Thr?Arg?Gly?Met?His?Ala?Glu?Pro?Trp?Asp?Lys?Phe?Val?Ser?Val?Ala

65 70 75 80

Val?Gly?Ser?Val?Phe?Gly?Ala?Trp?Val?Asp?Leu?Arg?Ala?Gly?Ser?Ser

85 90 95

Thr?Tyr?Gly?Asn?Val?Val?Thr?Gln?Lys?Ile?Thr?Pro?Asp?Val?Gly?Val

100 105 110

Tyr?Val?Pro?Arg?Gly?Val?Ala?Asn?Gly?Phe?Gln?Ala?Leu?Glu?Asp?Gly

115 120 125

Thr?Leu?Tyr?Thr?Tyr?Leu?Val?Asn?Asp?His?Trp?Ser?Pro?Asp?Ala?His

130 135 140

Tyr?Ala?Asn?Val?Asn?Leu?Asn?Met?Ile?Asp?Trp?Pro?Leu?Pro?Ile?Thr

145 150 155 160

Glu?Ile?Ser?Glu?Lys?Asp?Lys?Lys?His?Pro?Ala?Leu?Ile?Asp?Ala?Thr

165 170 175

Pro?Leu?Pro?Ala?Arg?Lys?Val?Leu?Val?Val?Gly?Ala?Gly?Gly?Gln?Leu

180 185 190

Gly?Thr?Ala?Leu?Arg?Ala?Gln?Phe?Pro?Asp?Ala?Glu?Phe?Val?Thr?Arg

195 200 205

Gln?Glu?Leu?Asp?Ile?Thr?Ser?Asp?Leu?Thr?Glu?Ala?Arg?Ala?Trp?Lys

210 215 220

Gln?Tyr?Ser?Thr?Ile?Ile?Asn?Ala?Ala?Ala?Tyr?Thr?Ala?Val?Asp?Gln

225 230 235 240

Ala?Glu?His?Asp?Arg?Ala?Ala?Ala?Trp?Asp?Ile?Asn?Ala?Ala?Ala?Val

245 250 255

Ala?Asn?Leu?Ala?Thr?Ile?Ala?Arg?Asp?Asn?Asn?Leu?Thr?Leu?Val?His

260 265 270

Val?Ser?Ser?Asp?Tyr?Val?Phe?Asp?Gly?Ala?Ala?Glu?Ser?Tyr?Asp?Glu

275 280 285

Asn?Ala?Pro?Phe?Ser?Pro?Leu?Gly?Val?Tyr?Gly?Gln?Ser?Lys?Ala?Ala

290 295 300

Gly?Asp?Ile?Gly?Asp?Thr?Thr?Ala?Pro?Arg?His?Tyr?Ile?Val?Arg?Thr

305 310 315 320

Ser?Trp?Val?Ile?Gly?Asp?Gly?Asn?Asn?Phe?Val?Arg?Thr?Met?Lys?Ser

325 330 335

Leu?Asp?Glu?Arg?Gly?Ile?Ala?Pro?Ser?Val?Val?Asp?Asp?Gln?Ile?Gly

340 345 350

Arg?Leu?Ser?Phe?Thr?Glu?Asp?Ile?Ala?Ala?Gly?Ile?Ala?His?Leu?Leu

355 360 365

Glu?Val?Gly?Ala?Ala?Tyr?Gly?Thr?Tyr?Asn?Leu?Thr?Asn?Thr?Gly?Glu

370 375 380

Pro?Ala?Ser?Trp?Ala?Asp?Val?Ala?Arg?Ala?Val?Phe?Ser?Asp?Pro?Thr

385 390 395 400

Lys?Val?Thr?Gly?Val?Ser?Thr?Ala?Glu?Tyr?Phe?Ala?Asn?Lys?Asp?Ala

405 410 415

Ala?Pro?Arg?Pro?Leu?Asn?Ser?Val?Leu?Asp?Leu?Gly?Lys?Ile?Glu?Ala

420 425 430

Thr?Gly?Phe?Ser?Ala?Pro?Thr?Trp?Gln?Thr?Arg?Leu?Asn?Asp?Tyr?Leu

435 440 445

Lys?Glu?Leu?Ser?Lys

450

<210>445

<211>449

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(426)

<223>FRXA01569

<400>445

gca?ccg?cgc?cac?tac?att?gtg?cgc?acc?agc?tgg?gtg?att?ggc?gat?ggc 48

Ala?Pro?Arg?His?Tyr?Ile?Val?Arg?Thr?Ser?Trp?Val?Ile?Gly?Asp?Gly

1 5 10 15

aat?aat?ttt?gtc?cgc?acc?atg?aaa?tcc?ctc?gac?gaa?cgc?ggc?atc?gca 96

Asn?Asn?Phe?Val?Arg?Thr?Met?Lys?Ser?Leu?Asp?Glu?Arg?Gly?Ile?Ala

20 25 30

cca?tea?gta?gtt?gat?gat?caa?atc?ggc?cgc?cta?tcc?ttc?acc?gaa?gac 144

Pro?Ser?Val?Val?Asp?Asp?Gln?Ile?Gly?Arg?Leu?Ser?Phe?Thr?Glu?Asp

35 40 45

atc?gca?gcc?ggc?atc?gcg?cac?ctt?ttg?gaa?gtg?ggt?gca?gca?tat?ggc 192

Ile?Ala?Ala?Gly?Ile?Ala?His?Leu?Leu?Glu?Val?Gly?Ala?Ala?Tyr?Gly

50 55 60

acc?tac?aac?ctc?acc?aac?acc?ggc?gaa?ccc?gca?agc?tgg?gcc?gat?gtt 240

Thr?Tyr?Asn?Leu?Thr?Asn?Thr?Gly?Glu?Pro?Ala?Ser?Trp?Ala?Asp?Val

65 70 75 80

gcc?cgc?gca?gta?ttt?tcc?gac?ccc?acc?aaa?gtt?acc?ggc?gtg?agc?acc 288

Ala?Arg?Ala?Val?Phe?Ser?Asp?Pro?Thr?Lys?Val?Thr?Gly?Val?Ser?Thr

85 90 95

gcc?gag?tac?ttc?gcc?aac?aaa?gac?gca?gcg?ccc?cgc?cca?ctg?aac?tcc 336

Ala?Glu?Tyr?Phe?Ala?Asn?Lys?Asp?Ala?Ala?Pro?Arg?Pro?Leu?Asn?Ser

100 105 110

gtt?ttg?gat?ctc?ggc?aaa?atc?gaa?gcc?acc?gga?ttt?agc?gca?ccg?acc 384

Val?Leu?Asp?Leu?Gly?Lys?Ile?Glu?Ala?Thr?Gly?Phe?Ser?Ala?Pro?Thr

115 120 125

tgg?cag?acc?cgc?ctc?aac?gac?tac?ctc?aag?gaa?ctc?tca?aag 426

Trp?Gln?Thr?Arg?Leu?Asn?Asp?Tyr?Leu?Lys?Glu?Leu?Ser?Lys

130 135 140

tgaaaggcat?catcctcgca?ggt 449

<210>446

<211>142

<212>PRT

＜213〉Corynebacterium glutamicum

<400>446

Ala?Pro?Arg?His?Tyr?Ile?Val?Arg?Thr?Ser?Trp?Val?Ile?Gly?Asp?Gly

1 5 10 15

Asn?Asn?Phe?Val?Arg?Thr?Met?Lys?Ser?Leu?Asp?Glu?Arg?Gly?Ile?Ala

20 25 30

Pro?Ser?Val?Val?Asp?Asp?Gln?Ile?Gly?Arg?Leu?Ser?Phe?Thr?Glu?Asp

35 40 45

Ile?Ala?Ala?Gly?Ile?Ala?His?Leu?Leu?Glu?Val?Gly?Ala?Ala?Tyr?Gly

50 55 60

Thr?Tyr?Asn?Leu?Thr?Asn?Thr?Gly?Glu?Pro?Ala?Ser?Trp?Ala?Asp?Val

65 70 75 80

Ala?Arg?Ala?Val?Phe?Ser?Asp?Pro?Thr?Lys?Val?Thr?Gly?Val?Ser?Thr

85 90 95

Ala?Glu?Tyr?Phe?Ala?Asn?Lys?Asp?Ala?Ala?Pro?Arg?Pro?Leu?Asn?Ser

100 105 1l0

Val?Leu?Asp?Leu?Gly?Lys?Ile?Glu?Ala?Thr?Gly?Phe?Ser?Ala?Pro?Thr

115 120 125

Trp?Gln?Thr?Arg?Leu?Asn?Asp?Tyr?Leu?Lys?Glu?Leu?Ser?Lys

130 135 140

<210>447

<211>1028

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1021)

<223>FRXA02055

<400>447

aaggcctaga?gcagaccatc?gattggtacc?gcgaaaacga?ggcctggtgg?cgccctgcca?60

agaacaacgt?cgaagctacc?tacgctaagc?agggacaata?atg?gaa?tac?ggt?aaa 115

Met?Glu?Tyr?Gly?Lys

1 5

caa?ctc?acc?tcc?cac?acc?acc?gac?atc?gaa?ggc?cta?ctg?gtt?ttc?gat 163

Gln?Leu?Thr?Ser?His?Thr?Thr?Asp?Ile?Glu?Gly?Leu?Leu?Val?Phe?Asp

10 15 20

ttc?ccc?gtc?cac?ggc?gac?aac?cgc?ggc?tgg?ttc?aag?gaa?aat?tgg?cag 211

Phe?Pro?Val?His?Gly?Asp?Asn?Arg?Gly?Trp?Phe?Lys?Glu?Asn?Trp?Gln

25 30 35

cgc?acc?aag?atg?acc?aac?ctg?ggg?ctg?ccc?gat?ttt?ggc?ccc?gtc?caa 259

Arg?Thr?Lys?Met?Thr?Asn?Leu?Gly?Leu?Pro?Asp?Phe?Gly?Pro?Val?Gln

40 45 50

aac?aac?atg?agt?ttc?aac?gcc?acc?gcc?ggc?acg?act?cgc?ggc?atg?cac 307

Asn?Asn?Met?Ser?Phe?Asn?Ala?Thr?Ala?Gly?Thr?Thr?Arg?Gly?Met?His

55 60 65

gct?gag?ccg?tgg?gat?aaa?ttt?gtg?tcc?gtc?gcg?gtg?ggt?tcc?gtt?ttc 355

Ala?Glu?Pro?Trp?Asp?Lys?Phe?Val?Ser?Val?Ala?Val?Gly?Ser?Val?Phe

70 75 80 85

gga?gct?tgg?gtg?gat?ctg?cgc?gcg?ggc?tcg?agc?acg?tac?ggt?aac?gtc 403

Gly?Ala?Trp?Val?Asp?Leu?Arg?Ala?Gly?Ser?Ser?Thr?Tyr?Gly?Asn?Val

90 95 100

gta?acg?caa?aaa?att?acc?cct?gac?gtg?gga?gtt?tac?gtc?ccg?cgt?ggt 451

Val?Thr?Gln?Lys?Ile?Thr?Pro?Asp?Val?Gly?Val?Tyr?Val?Pro?Arg?Gly

105 110 115

gtg?gca?aac?ggc?ttc?cag?gcg?ctc?gag?gac?ggc?acg?ctg?tac?acc?tac 499

Val?Ala?Asn?Gly?Phe?Gln?Ala?Leu?Glu?Asp?Gly?Thr?Leu?Tyr?Thr?Tyr

120 125 130

ctc?gtc?aac?gat?cat?tgg?tcc?ccc?gac?gcg?cat?tac?gcc?aac?gtc?aac 547

Leu?Val?Asn?Asp?His?Trp?Ser?Pro?Asp?Ala?His?Tyr?Ala?Asn?Val?Asn

135 140 145

ctc?aac?atg?atc?gac?tgg?ccg?ctg?ccc?atc?acc?gag?atc?tcc?gaa?aaa 595

Leu?Asn?Met?Ile?Asp?Trp?Pro?Leu?Pro?Ile?Thr?Glu?Ile?Ser?Glu?Lys

150 155 160 165

gat?aaa?aaa?cat?cca?gcg?ctt?atc?gac?gcc?acc?ccc?ctg?ccc?gcc?cgc 643

Asp?Lys?Lys?His?Pro?Ala?Leu?Ile?Asp?Ala?Thr?Pro?Leu?Pro?Ala?Arg

170 175 180

aag?gtt?ctc?gtg?gtc?ggc?gcc?ggc?gga?caa?ctg?gga?acc?gcg?cta?cgc 691

Lys?Val?Leu?Val?Val?Gly?Ala?Gly?Gly?Gln?Leu?Gly?Thr?Ala?Leu?Arg

185 190 195

gcg?cag?ttc?cca?gac?gcg?gaa?ttt?gtc?acg?cgc?caa?gaa?ctc?gat?atc 739

Ala?Gln?Phe?Pro?Asp?Ala?Glu?Phe?Val?Thr?Arg?Gln?Glu?Leu?Asp?Ile

200 205 210

acc?tca?gat?ctc?acc?gag?gct?cgc?gcg?tgg?aaa?caa?tac?tcc?acc?atc 787

Thr?Ser?Asp?Leu?Thr?Glu?Ala?Arg?Ala?Trp?Lys?Gln?Tyr?Ser?Thr?Ile

215 220 225

ata?aac?gcc?gcc?gcc?tac?act?gcc?gtt?gac?cag?gca?gaa?cac?gac?cgc 835

Ile?Asn?Ala?Ala?Ala?Tyr?Thr?Ala?Val?Asp?Gln?Ala?Glu?His?Asp?Arg

230 235 240 245

gca?gca?gcg?tgg?gac?att?aac?gca?gcg?gca?gtg?gct?acc?tcg?cga?cca 883

Ala?Ala?Ala?Trp?Asp?Ile?Asn?Ala?Ala?Ala?Val?Ala?Thr?Ser?Arg?Pro

250 255 260

tcg?cgc?gcg?aca?aca?acc?tca?ccc?tcg?tgc?acg?tgt?cct?cag?att?atg 931

Ser?Arg?Ala?Thr?Thr?Thr?Ser?Pro?Ser?Cys?Thr?Cys?Pro?Gln?Ile?Met

265 270 275

tct?tcg?acg?gtg?cgg?gcg?aat?cct?acg?atg?aaa?acg?cac?cgt?ttt?ccc 979

Ser?Ser?Thr?Val?Arg?Ala?Asn?Pro?Thr?Met?Lys?Thr?His?Arg?Phe?Pro

280 285 290

cac?tcg?gcg?tgt?acg?gcc?aat?cca?aag?cag?ccg?gcg?aca?tcg 1021

His?Ser?Ala?Cys?Thr?Ala?Asn?Pro?Lys?Gln?Pro?Ala?Thr?Ser

295 300 305

taagcac 1028

<210>448

<211>307

<212>PRT

＜213〉Corynebacterium glutamicum

<400>448

Met?Glu?Tyr?Gly?Lys?Gln?Leu?Thr?Ser?His?Thr?Thr?Asp?Ile?Glu?Gly

1 5 10 15

Leu?Leu?Val?Phe?Asp?Phe?Pro?Val?His?Gly?Asp?Asn?Arg?Gly?Trp?Phe

20 25 30

Lys?Glu?Asn?Trp?Gln?Arg?Thr?Lys?Met?Thr?Asn?Leu?Gly?Leu?Pro?Asp

35 40 45

Phe?Gly?Pro?Val?Gln?Asn?Asn?Met?Ser?Phe?Asn?Ala?Thr?Ala?Gly?Thr

50 55 60

Thr?Arg?Gly?Met?His?Ala?Glu?Pro?Trp?Asp?Lys?Phe?Val?Ser?Val?Ala

65 70 75 80

Val?Gly?Ser?Val?Phe?Gly?Ala?Trp?Val?Asp?Leu?Arg?Ala?Gly?Ser?Ser

85 90 95

Thr?Tyr?Gly?Asn?Val?Val?Thr?Gln?Lys?Ile?Thr?Pro?Asp?Val?Gly?Val

100 105 110

Tyr?Val?Pro?Arg?Gly?Val?Ala?Asn?Gly?Phe?Gln?Ala?Leu?Glu?Asp?Gly

115 120 125

Thr?Leu?Tyr?Thr?Tyr?Leu?Val?Asn?Asp?His?Trp?Ser?Pro?Asp?Ala?His

130 135 140

Tyr?Ala?Asn?Val?Asn?Leu?Asn?Met?Ile?Asp?Trp?Pro?Leu?Pro?Ile?Thr

145 150 155 160

Glu?Ile?Ser?Glu?Lys?Asp?Lys?Lys?His?Pro?Ala?Leu?Ile?Asp?Ala?Thr

165 170 175

Pro?Leu?Pro?Ala?Arg?Lys?Val?Leu?Val?Val?Gly?Ala?Gly?Gly?Gln?Leu

180 185 190

Gly?Thr?Ala?Leu?Arg?Ala?Gln?Phe?Pro?Asp?Ala?Glu?Phe?Val?Thr?Arg

195 200 205

Gln?Glu?Leu?Asp?Ile?Thr?Ser?Asp?Leu?Thr?Glu?Ala?Arg?Ala?Trp?Lys

210 215 220

Gln?Tyr?Ser?Thr?Ile?Ile?Asn?Ala?Ala?Ala?Tyr?Thr?Ala?Val?Asp?Gln

225 230 235 240

Ala?Glu?His?Asp?Arg?Ala?Ala?Ala?Trp?Asp?Ile?Asn?Ala?Ala?Ala?Val

245 250 255

Ala?Thr?Ser?Arg?Pro?Ser?Arg?Ala?Thr?Thr?Thr?Ser?Pro?Ser?Cys?Thr

260 265 270

Cys?Pro?Gln?Ile?Met?Ser?Ser?Thr?Val?Arg?Ala?Asn?Pro?Thr?Met?Lys

275 280 285

Thr?His?Arg?Phe?Pro?His?Ser?Ala?Cys?Thr?Ala?Asn?Pro?Lys?Gln?Pro

290 295 300

Ala?Thr?Ser

305

<210>449

<211>1056

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1033)

<223>RXA00825

<400>449

cccgttcatg?ctgggctttg?gtgcggtgat?ggcaactatt?tgtctgatca?ttgtgagttt?60

tagtgcacgc?cgattctgag?aaacaactaa?agtgagccac?atg?cgc?aca?gta?gtt 115

Met?Arg?Thr?Val?Val

1 5

acc?ggc?ggt?gcc?ggc?ttc?atc?gga?tcc?cat?ctc?gtt?gac?ctt?ttg?atc 163

Thr?Gly?Gly?Ala?Gly?Phe?Ile?Gly?Ser?His?Leu?Val?Asp?Leu?Leu?Ile

10 15 20

aag?gaa?ggc?cac?gag?gtc?gtt?gtg?atc?gat?aac?ctc?tcc?cgc?gga?cgc 211

Lys?Glu?Gly?His?Glu?Val?Val?Val?Ile?Asp?Asn?Leu?Ser?Arg?Gly?Arg

25 30 35

ctg?gag?aat?ctc?tcc?gat?gcg?gaa?gcc?acc?gga?aaa?ctc?acc?ttt?gtg 259

Leu?Glu?Asn?Leu?Ser?Asp?Ala?Glu?Ala?Thr?Gly?Lys?Leu?Thr?Phe?Val

40 45 50

gaa?gcc?gat?ctt?ctc?gac?gtt?gat?ttc?aac?gag?ttt?cta?gga?acc?cac 307

Glu?Ala?Asp?Leu?Leu?Asp?Val?Asp?Phe?Asn?Glu?Phe?Leu?Gly?Thr?His

55 60 65

aag?cct?gag?gtt?att?ttc?cac?ctg?gca?gcg?caa?atc?gat?gtg?cgc?cac 355

Lys?Pro?Glu?Val?Ile?Phe?His?Leu?Ala?Ala?Gln?Ile?Asp?Val?Arg?His

70 75 80 85

tct?gtt?gta?gat?cct?ctt?cac?gac?gcc?gaa?acc?aac?att?ttg?tcc?acc 403

Ser?Val?Val?Asp?Pro?Leu?His?Asp?Ala?Glu?Thr?Asn?Ile?Leu?Ser?Thr

90 95 100

atc?cgc?atc?gct?gac?gct?gcc?cgc?cag?cac?ggt?gtt?cgc?aag?gtt?gtc 451

Ile?Arg?Ile?Ala?Asp?Ala?Ala?Arg?Gln?His?Gly?Val?Arg?Lys?Val?Val

105 110 115

ttt?acc?tcc?tca?ggc?ggt?tcc?att?tac?ggt?gag?cct?tcg?gaa?ttc?cca 499

Phe?Thr?Ser?Ser?Gly?Gly?Ser?Ile?Tyr?Gly?Glu?Pro?Ser?Glu?Phe?Pro

120 125 130

gtt?gat?gaa?acc?gtg?cca?gtg?gat?cca?cat?tcc?cct?tat?gcg?gca?tcc 547

Val?Asp?Glu?Thr?Val?Pro?Val?Asp?Pro?His?Ser?Pro?Tyr?Ala?Ala?Ser

135 140 145

aag?gtg?tcc?ggt?gaa?att?tac?ctg?aac?acc?ttc?cgc?cac?ctg?tac?ggc 595

Lys?Val?Ser?Gly?Glu?Ile?Tyr?Leu?Asn?Thr?Phe?Arg?His?Leu?Tyr?Gly

150 155 160 165

tta?gac?tgt?tct?cac?atc?gca?ccg?gca?aat?gtt?tac?ggc?cca?cgc?caa 643

Leu?Asp?Cys?Ser?His?Ile?Ala?Pro?Ala?Asn?Val?Tyr?Gly?Pro?Arg?Gln

170 175 180

gat?cca?cac?ggt?gaa?gca?gga?gtt?gtg?gcc?att?ttc?gcg?ctg?cga?ctt 691

Asp?Pro?His?Gly?Glu?Ala?Gly?Val?Val?Ala?Ile?Phe?Ala?Leu?Arg?Leu

185 190 195

ctg?gga?ggc?ctg?gac?acc?aag?gta?ttc?ggc?gac?ggc?gga?aac?acc?cgc 739

Leu?Gly?Gly?Leu?Asp?Thr?Lys?Val?Phe?Gly?Asp?Gly?Gly?Asn?Thr?Arg

200 205 210

gac?tac?gtc?tac?gtc?ggt?gac?gta?gtt?cgt?gct?ttc?tac?ctg?gct?tct 787

Asp?Tyr?Val?Tyr?Val?Gly?Asp?Val?Val?Arg?Ala?Phe?Tyr?Leu?Ala?Ser

215 220 225

ggg?gaa?atc?ggt?ggg?gga?gag?cgc?ttc?aac?att?ggc?acc?tct?gtg?gaa 835

Gly?Glu?Ile?Gly?Gly?Gly?Glu?Arg?Phe?Asn?Ile?Gly?Thr?Ser?Val?Glu

230 235 240 245

acc?tct?gac?cgc?cag?ctg?cac?acc?ctc?gtg?gcc?act?gcg?gca?ggt?tcc 883

Thr?Ser?Asp?Arg?Gln?Leu?His?Thr?Leu?Val?Ala?Thr?Ala?Ala?Gly?Ser

250 255 260

aaa?gat?gat?cct?gaa?tat?gca?cct?gca?cgt?ctc?ggc?gat?gtg?cca?cgc 931

Lys?Asp?Asp?Pro?Glu?Tyr?Ala?Pro?Ala?Arg?Leu?Gly?Asp?Val?Pro?Arg

265 270 275

agt?gca?ctc?agc?ttc?ggc?aag?gcc?aaa?gag?gtg?ctt?ggt?tgg?gag?cct 979

Ser?Ala?Leu?Ser?Phe?Gly?Lys?Ala?Lys?Glu?Val?Leu?Gly?Trp?Glu?Pro

280 285 290

gag?gtg?aac?atc?gaa?caa?ggt?gtg?gcc?aag?act?gtg?gag?tac?ttc?cgc 1027

Glu?Val?Asn?Ile?Glu?Gln?Gly?Val?Ala?Lys?Thr?Val?Glu?Tyr?Phe?Arg

295 300 305

act?cac?taggggaaaa?tccaccacaa?atc 1056

Thr?His

310

<210>450

<211>311

<212>PRT

＜213〉Corynebacterium glutamicum

<400>450

Met?Arg?Thr?Val?Val?Thr?Gly?Gly?Ala?Gly?Phe?Ile?Gly?Ser?His?Leu

1 5 10 15

Val?Asp?Leu?Leu?Ile?Lys?Glu?Gly?His?Glu?Val?Val?Val?Ile?Asp?Asn

20 25 30

Leu?Ser?Arg?Gly?Arg?Leu?Glu?Asn?Leu?Ser?Asp?Ala?Glu?Ala?Thr?Gly

35 40 45

Lys?Leu?Thr?Phe?Val?Glu?Ala?Asp?Leu?Leu?Asp?Val?Asp?Phe?Asn?Glu

50 55 60

Phe?Leu?Gly?Thr?His?Lys?Pro?Glu?Val?Ile?Phe?His?Leu?Ala?Ala?Gln

65 70 75 80

Ile?Asp?Val?Arg?His?Ser?Val?Val?Asp?Pro?Leu?His?Asp?Ala?Glu?Thr

85 90 95

Asn?Ile?Leu?Ser?Thr?Ile?Arg?Ile?Ala?Asp?Ala?Ala?Arg?Gln?His?Gly

100 105 110

Val?Arg?Lys?Val?Val?Phe?Thr?Ser?Ser?Gly?Gly?Ser?Ile?Tyr?Gly?Glu

115 120 125

Pro?Ser?Glu?Phe?Pro?Val?Asp?Glu?Thr?Val?Pro?Val?Asp?Pro?His?Ser

130 135 140

Pro?Tyr?Ala?Ala?Ser?Lys?Val?Ser?Gly?Glu?Ile?Tyr?Leu?Asn?Thr?Phe

145 150 155 160

Arg?His?Leu?Tyr?Gly?Leu?Asp?Cys?Ser?His?Ile?Ala?Pro?Ala?Asn?Val

165 170 175

Tyr?Gly?Pro?Arg?Gln?Asp?Pro?His?Gly?Glu?Ala?Gly?Val?Val?Ala?Ile

180 185 190

Phe?Ala?Leu?Arg?Leu?Leu?Gly?Gly?Leu?Asp?Thr?Lys?Val?Phe?Gly?Asp

195 200 205

Gly?Gly?Asn?Thr?Arg?Asp?Tyr?Val?Tyr?Val?Gly?Asp?Val?Val?Arg?Ala

210 215 220

Phe?Tyr?Leu?Ala?Ser?Gly?Glu?Ile?Gly?Gly?Gly?Glu?Arg?Phe?Asn?Ile

225 230 235 240

Gly?Thr?Ser?Val?Glu?Thr?Ser?Asp?Arg?Gln?Leu?His?Thr?Leu?Val?Ala

245 250 255

Thr?Ala?Ala?Gly?Ser?Lys?Asp?Asp?Pro?Glu?Tyr?Ala?Pro?Ala?Arg?Leu

260 265 270

Gly?Asp?Val?Pro?Arg?Ser?Ala?Leu?Ser?Phe?Gly?Lys?Ala?Lys?Glu?Val

275 280 285

Leu?Gly?Trp?Glu?Pro?Glu?Val?Asn?Ile?Glu?Gln?Gly?Val?Ala?Lys?Thr

290 295 300

Val?Glu?Tyr?Phe?Arg?Thr?His

305 310

<210>451

<211>1140

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1117)

<223>RXA02054

<400>451

cctaatgaac?agccggagca?ccctggtcgt?ttgcagaata?ggcgcatcga?caacagctac?60

taactctgcc?agctcgcccg?gacgaactaa?ggtagacggc?atg?act?tct?ttg?ctt 115

Met?Thr?Ser?Leu?Leu

1 5

gtg?acc?gga?ggt?gcc?gga?ttt?atc?ggc?gcc?aac?ttc?gtc?cgc?caa?acc 163

Val?Thr?Gly?Gly?Ala?Gly?Phe?Ile?Gly?Ala?Asn?Phe?Val?Arg?Gln?Thr

10 15 20

gta?gag?cag?cac?cct?gaa?tac?acc?cac?atc?acg?gtg?ctg?gat?aaa?ctc 211

Val?Glu?Gln?His?Pro?Glu?Tyr?Thr?His?Ile?Thr?Val?Leu?Asp?Lys?Leu

25 30 35

acc?tac?gca?gga?aac?gcc?gac?aat?ctc?aaa?ggc?ctc?ccc?gac?agc?aaa 259

Thr?Tyr?Ala?Gly?Asn?Ala?Asp?Asn?Leu?Lys?Gly?Leu?Pro?Asp?Ser?Lys

40 45 50

gta?acc?ctc?atc?gaa?ggc?gat?atc?tgc?gat?gct?gaa?tta?gtc?gac?tcc 307

Val?Thr?Leu?Ile?Glu?Gly?Asp?Ile?Cys?Asp?Ala?Glu?Leu?Val?Asp?Ser

55 60 65

ctg?gtc?aaa?gac?cac?gac?atc?aca?gtc?cac?ttc?gca?gca?gaa?tcc?cac 355

Leu?Val?Lys?Asp?His?Asp?Ile?Thr?Val?His?Phe?Ala?Ala?Glu?Ser?His

70 75 80 85

aac?gac?aac?tcc?ctc?aac?gac?ccc?tcc?ccg?ttt?gtt?cac?act?aac?ctc 403

Asn?Asp?Asn?Ser?Leu?Asn?Asp?Pro?Ser?Pro?Phe?Val?His?Thr?Asn?Leu

90 95 100

atc?ggc?acc?ttt?gtc?ctg?cta?gaa?gca?gtc?cgc?aag?cac?aac?aaa?cgc 451

Ile?Gly?Thr?Phe?Val?Leu?Leu?Glu?Ala?Val?Arg?Lys?His?Asn?Lys?Arg

105 110 115

ttc?cac?cac?atc?tcc?acc?gat?gaa?gtc?ttc?ggc?gat?cta?gag?ctg?gat 499

Phe?His?His?Ile?Ser?Thr?Asp?Glu?Val?Phe?Gly?Asp?Leu?Glu?Leu?Asp

120 125 130

gat?cca?aac?cgc?ttc?act?gaa?acc?acc?gcc?tac?aag?cca?tcg?tct?cca 547

Asp?Pro?Asn?Arg?Phe?Thr?Glu?Thr?Thr?Ala?Tyr?Lys?Pro?Ser?Ser?Pro

135 140 145

tat?tct?gca?acc?aag?gca?ggg?tct?gat?cac?ttg?gta?cac?gca?tgg?atc 595

Tyr?Ser?Ala?Thr?Lys?Ala?Gly?Ser?Asp?His?Leu?Val?His?Ala?Trp?Ile

150 155 160 165

cgc?tcc?ttc?gga?atc?cag?gca?acc?atg?tct?aac?tgc?tcc?aac?aat?tac 643

Arg?Ser?Phe?Gly?Ile?Gln?Ala?Thr?Met?Ser?Asn?Cys?Ser?Asn?Asn?Tyr

170 175 180

ggt?ccc?tac?cag?cac?att?gaa?aag?ttc?atc?ccc?cgc?cag?atc?acc?aat 691

Gly?Pro?Tyr?Gln?His?Ile?Glu?Lys?Phe?Ile?Pro?Arg?Gln?Ile?Thr?Asn

185 190 195

att?ctg?gcc?ggc?ctg?aca?cca?aaa?ctt?tat?gga?acc?ggc?gag?cag?gtc 739

Ile?Leu?Ala?Gly?Leu?Thr?Pro?Lys?Leu?Tyr?Gly?Thr?Gly?Glu?Gln?Val

200 205 210

cgc?gac?tgg?atc?cac?gtc?gat?gat?cac?aat?gac?gcc?gtc?cac?ctg?atc 787

Arg?Asp?Trp?Ile?His?Val?Asp?Asp?His?Asn?Asp?Ala?Val?His?Leu?Ile

215 220 225

ctg?agt?aag?ggc?aag?atc?ggc?gaa?acc?tac?atc?atc?ggc?gcc?gac?aac 835

Leu?Ser?Lys?Gly?Lys?Ile?Gly?Glu?Thr?Tyr?Ile?Ile?Gly?Ala?Asp?Asn

230 235 240 245

gat?cat?gtg?aat?aac?aag?cag?gtc?atc?gag?ctt?att?tgt?gaa?ctc?atg 883

Asp?His?Val?Asn?Asn?Lys?Gln?Val?Ile?Glu?Leu?Ile?Cys?Glu?Leu?Met

250 255 260

ggc?ctc?gac?aaa?aac?gca?tac?gag?cac?gtc?gca?gac?cgc?ccc?ggc?cac 931

Gly?Leu?Asp?Lys?Asn?Ala?Tyr?Glu?His?Val?Ala?Asp?Arg?Pro?Gly?His

265 270 275

gat?atg?cgt?tac?gcc?atg?gat?tcc?acc?aag?ctg?cgc?acc?gag?ctc?ggc 979

Asp?Met?Arg?Tyr?Ala?Met?Asp?Ser?Thr?Lys?Leu?Arg?Thr?Glu?Leu?Gly

280 285 290

tgg?gca?cct?aaa?tac?acc?gac?gtt?gat?tcc?ggc?atg?cgc?aaa?ggc?cta 1027

Trp?Ala?Pro?Lys?Tyr?Thr?Asp?Val?Asp?Ser?Gly?Met?Arg?Lys?Gly?Leu

295 300 305

gag?cag?acc?atc?gat?tgg?tac?cgc?gaa?aac?gag?gcc?tgg?tgg?cgc?cct 1075

Glu?Gln?Thr?Ile?Asp?Trp?Tyr?Arg?Glu?Asn?Glu?Ala?Trp?Trp?Arg?Pro

310 315 320 325

gcc?aag?aac?aac?gtc?gaa?gct?acc?tac?gct?aag?cag?gga?caa 1117

Ala?Lys?Asn?Asn?Val?Glu?Ala?Thr?Tyr?Ala?Lys?Gln?Gly?Gln

330 335

taatggaata?cggtaaacaa?ctc 1140

<210>452

<211>339

<212>PRT

＜213〉Corynebacterium glutamicum

<400>452

Met?Thr?Ser?Leu?Leu?Val?Thr?Gly?Gly?Ala?Gly?Phe?Ile?Gly?Ala?Asn

1 5 10 15

Phe?Val?Arg?Gln?Thr?Val?Glu?Gln?His?Pro?Glu?Tyr?Thr?His?Ile?Thr

20 25 30

Val?Leu?Asp?Lys?Leu?Thr?Tyr?Ala?Gly?Asn?Ala?Asp?Asn?Leu?Lys?Gly

35 40 45

Leu?Pro?Asp?Ser?Lys?Val?Thr?Leu?Ile?Glu?Gly?Asp?Ile?Cys?Asp?Ala

50 55 60

Glu?Leu?Val?Asp?Ser?Leu?Val?Lys?Asp?His?Asp?Ile?Thr?Val?His?Phe

65 70 75 80

Ala?Ala?Glu?Ser?His?Asn?Asp?Asn?Ser?Leu?Asn?Asp?Pro?Ser?Pro?Phe

85 90 95

Val?His?Thr?Asn?Leu?Ile?Gly?Thr?Phe?Val?Leu?Leu?Glu?Ala?Val?Arg

100 105 110

Lys?His?Asn?Lys?Arg?Phe?His?His?Ile?Ser?Thr?Asp?Glu?Val?Phe?Gly

115 120 125

Asp?Leu?Glu?Leu?Asp?Asp?Pro?Asn?Arg?Phe?Thr?Glu?Thr?Thr?Ala?Tyr

130 135 140

Lys?Pro?Ser?Ser?Pro?Tyr?Ser?Ala?Thr?Lys?Ala?Gly?Ser?Asp?His?Leu

145 150 155 160

Val?His?Ala?Trp?Ile?Arg?Ser?Phe?Gly?Ile?Gln?Ala?Thr?Met?Ser?Asn

165 170 175

Cys?Ser?Asn?Asn?Tyr?Gly?Pro?Tyr?Gln?His?Ile?Glu?Lys?Phe?Ile?Pro

180 185 190

Arg?Gln?Ile?Thr?Asn?Ile?Leu?Ala?Gly?Leu?Thr?Pro?Lys?Leu?Tyr?Gly

195 200 205

Thr?Gly?Glu?Gln?Val?Arg?Asp?Trp?Ile?His?Val?Asp?Asp?His?Asn?Asp

210 215 220

Ala?Val?His?Leu?Ile?Leu?Ser?Lys?Gly?Lys?Ile?Gly?Glu?Thr?Tyr?Ile

225 230 235 240

Ile?Gly?Ala?Asp?Asn?Asp?His?Val?Asn?Asn?Lys?Gln?Val?Ile?Glu?Leu

245 250 255

Ile?Cys?Glu?Leu?Met?Gly?Leu?Asp?Lys?Asn?Ala?Tyr?Glu?His?Val?Ala

260 265 270

Asp?Arg?Pro?Gly?His?Asp?Met?Arg?Tyr?Ala?Met?Asp?Ser?Thr?Lys?Leu

275 280 285

Arg?Thr?Glu?Leu?Gly?Trp?Ala?Pro?Lys?Tyr?Thr?Asp?Val?Asp?Ser?Gly

290 295 300

Met?Arg?Lys?Gly?Leu?Glu?Gln?Thr?Ile?Asp?Trp?Tyr?Arg?Glu?Asn?Glu

305 310 315 320

Ala?Trp?Trp?Arg?Pro?Ala?Lys?Asn?Asn?Val?Glu?Ala?Thr?Tyr?Ala?Lys

325 330 335

Gln?Gly?Gln

<210>453

<211>909

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(886)

<223>RXN00427

<400>453

gcggtcattg?tgacccacaa?tcgtgtggaa?ttgctgcggc?attccctcga?ggttgttgcc?60

aatcaaacct?atccggtgaa?acacattgtg?gtggtggata?atg?ggg?cgg?atc?cta 115

Met?Gly?Arg?Ile?Leu

1 5

gta?ttc?tat?agt?gtc?act?tta?gag?gtg?gcg?gga?gac?cgt?ccc?gtt?tac 163

Val?Phe?Tyr?Ser?Val?Thr?Leu?Glu?Val?Ala?Gly?Asp?Arg?Pro?Val?Tyr

10 15 20

acg?cct?tcg?cgc?acc?aat?ttg?ggc?gac?ggt?ggc?ggt?ttt?gct?ttt?ggt 211

Thr?Pro?Ser?Arg?Thr?Asn?Leu?Gly?Asp?Gly?Gly?Gly?Phe?Ala?Phe?Gly

25 30 35

ttt?ttg?acg?gcg?ttg?gcg?ctg?ggg?gcg?aac?gcg?gtg?tgg?tgc?aca?gac 259

Phe?Leu?Thr?Ala?Leu?Ala?Leu?Gly?Ala?Asn?Ala?Val?Trp?Cys?Thr?Asp

40 45 50

gat?gac?ggc?cgg?ccg?gag?ggg?cca?ggg?gtg?ttg?aag?acg?ctt?atc?gac 307

Asp?Asp?Gly?Arg?Pro?Glu?Gly?Pro?Gly?Val?Leu?Lys?Thr?Leu?Ile?Asp

55 60 65

gcc?gct?tct?cgg?cat?aat?ctg?gag?gag?gtt?tct?ccg?gtg?gta?tgc?aat 355

Ala?Ala?Ser?Arg?His?Asn?Leu?Glu?Glu?Val?Ser?Pro?Val?Val?Cys?Asn

70 75 80 85

gct?gat?gat?ccg?gag?cgg?ttg?gca?ttt?ccg?ctg?cgt?cgg?ggc?ttg?gag 403

Ala?Asp?Asp?Pro?Glu?Arg?Leu?Ala?Phe?Pro?Leu?Arg?Arg?Gly?Leu?Glu

90 95 100

tgg?cgt?cgg?atg?cgc?agt?gag?ttg?att?gat?cca?gcc?aac?ccg?gag?gat 451

Trp?Arg?Arg?Met?Arg?Ser?Glu?Leu?Ile?Asp?Pro?Ala?Asn?Pro?Glu?Asp

105 110 115

gat?ttg?ctg?ccg?ggc?atc?gcc?tcc?ttg?ttc?aat?ggt?gcc?ctg?atc?agc 499

Asp?Leu?Leu?Pro?Gly?Ile?Ala?Ser?Leu?Phe?Asn?Gly?Ala?Leu?Ile?Ser

120 125 130

gct?tat?gca?atg?gag?cgc?att?ggc?gtg?ccg?gac?tat?cga?ctg?ttt?att 547

Ala?Tyr?Ala?Met?Glu?Arg?Ile?Gly?Val?Pro?Asp?Tyr?Arg?Leu?Phe?Ile

135 140 145

cgc?ggc?gat?gag?gtg?gag?tat?cac?cgc?cgt?ttg?gtg?cgt?tcc?ggt?ttg 595

Arg?Gly?Asp?Glu?Val?Glu?Tyr?His?Arg?Arg?Leu?Val?Arg?Ser?Gly?Leu

150 155 160 165

ccg?ttt?ggt?acg?tgt?ttg?acc?acg?gcg?tat?ttg?cac?ccg?gat?ggt?tct 643

Pro?Phe?Gly?Thr?Cys?Leu?Thr?Thr?Ala?Tyr?Leu?His?Pro?Asp?Gly?Ser

170 175 180

gat?gag?ttc?aag?ccg?att?ctg?ggt?ggg?cgg?atg?cat?acg?cag?tat?ccg 691

Asp?Glu?Phe?Lys?Pro?Ile?Leu?Gly?Gly?Arg?Met?His?Thr?Gln?Tyr?Pro

185 190 195

gat?aat?gat?ttc?aag?agg?ttt?ttc?acc?tac?cgc?aac?cgt?ggc?tac?ctg 739

Asp?Asn?Asp?Phe?Lys?Arg?Phe?Phe?Thr?Tyr?Arg?Asn?Arg?Gly?Tyr?Leu

200 205 210

atg?agc?cag?ccg?gga?atg?cgc?aag?ctt?ctc?cct?cag?gaa?tat?gcg?cgc 787

Met?Ser?Gln?Pro?Gly?Met?Arg?Lys?Leu?Leu?Pro?Gln?Glu?Tyr?Ala?Arg

215 220 225

ttt?gcg?tgg?ttc?ttc?ctg?gtt?cag?aaa?cgg?gat?gtg?aag?gga?ttc?cgg 835

Phe?Ala?Trp?Phe?Phe?Leu?Val?Gln?Lys?Arg?Asp?Val?Lys?Gly?Phe?Arg

230 235 240 245

gag?tgg?ctg?cgc?ctg?cac?aaa?ctg?ggc?cgc?gac?gag?aaa?ttc?aat?agg 883

Glu?Trp?Leu?Arg?Leu?His?Lys?Leu?Gly?Arg?Asp?Glu?Lys?Phe?Asn?Arg

250 255 260

ccc?tagatcagtt?ttagtagttc?ctc 909

Pro

<210>454

<211>262

<212>PRT

＜213〉Corynebacterium glutamicum

<400>454

Met?Gly?Arg?Ile?Leu?Val?Phe?Tyr?Ser?Val?Thr?Leu?Glu?Val?Ala?Gly

1 5 10 15

Asp?Arg?Pro?Val?Tyr?Thr?Pro?Ser?Arg?Thr?Asn?Leu?Gly?Asp?Gly?Gly

20 25 30

Gly?Phe?Ala?Phe?Gly?Phe?Leu?Thr?Ala?Leu?Ala?Leu?Gly?Ala?Asn?Ala

35 40 45

Val?Trp?Cys?Thr?Asp?Asp?Asp?Gly?Arg?Pro?Glu?Gly?Pro?Gly?Val?Leu

50 55 60

Lys?Thr?Leu?Ile?Asp?Ala?Ala?Ser?Arg?His?Asn?Leu?Glu?Glu?Val?Ser

65 70 75 80

Pro?Val?Val?Cys?Asn?Ala?Asp?Asp?Pro?Glu?Arg?Leu?Ala?Phe?Pro?Leu

85 90 95

Arg?Arg?Gly?Leu?Glu?Trp?Arg?Arg?Met?Arg?Ser?Glu?Leu?Ile?Asp?Pro

100 105 110

Ala?Asn?Pro?Glu?Asp?Asp?Leu?Leu?Pro?Gly?Ile?Ala?Ser?Leu?Phe?Asn

115 120 125

Gly?Ala?Leu?Ile?Ser?Ala?Tyr?Ala?Met?Glu?Arg?Ile?Gly?Val?Pro?Asp

130 135 140

Tyr?Arg?Leu?Phe?Ile?Arg?Gly?Asp?Glu?Val?Glu?Tyr?His?Arg?Arg?Leu

145 150 155 160

Val?Arg?Ser?Gly?Leu?Pro?Phe?Gly?Thr?Cys?Leu?Thr?Thr?Ala?Tyr?Leu

165 170 175

His?Pro?Asp?Gly?Ser?Asp?Glu?Phe?Lys?Pro?Ile?Leu?Gly?Gly?Arg?Met

180 185 190

His?Thr?Gln?Tyr?Pro?Asp?Asn?Asp?Phe?Lys?Arg?Phe?Phe?Thr?Tyr?Arg

195 200 205

Asn?Arg?Gly?Tyr?Leu?Met?Ser?Gln?Pro?Gly?Met?Arg?Lys?Leu?Leu?Pro

210 215 220

Gln?Glu?Tyr?Ala?Arg?Phe?Ala?Trp?Phe?Phe?Leu?Val?Gln?Lys?Arg?Asp

225 230 235 240

Val?Lys?Gly?Phe?Arg?Glu?Trp?Leu?Arg?Leu?His?Lys?Leu?Gly?Arg?Asp

245 250 255

Glu?Lys?Phe?Asn?Arg?Pro

260

<210>455

<211>555

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(532)

<223>FRXA00427

<400>455

tgctgatgat?ccggagcggt?tggcatttcc?gctgcgtcgg?ggcttggagt?ggcgtcggat?60

gcgcagtgag?ttgattgatc?cagccaaccc?ggaggatgat?ttg?ctg?ccg?ggc?atc 115

Leu?Leu?Pro?Gly?Ile

1 5

gcc?tcc?ttg?ttc?aat?ggt?gcc?ctg?atc?agc?gct?tat?gca?atg?gag?cgc 163

Ala?Ser?Leu?Phe?Asn?Gly?Ala?Leu?Ile?Ser?Ala?Tyr?Ala?Met?Glu?Arg

l0 15 20

att?ggc?gtg?ccg?gac?tat?cga?ctg?ttt?att?cgc?ggc?gat?gag?gtg?gag 211

Ile?Gly?Val?Pro?Asp?Tyr?Arg?Leu?Phe?Ile?Arg?Gly?Asp?Glu?Val?Glu

25 30 35

tat?cac?cgc?cgt?ttg?gtg?cgt?tcc?ggt?ttg?ccg?ttt?ggt?acg?tgt?ttg 259

Tyr?His?Arg?Arg?Leu?Val?Arg?Ser?Gly?Leu?Pro?Phe?Gly?Thr?Cys?Leu

40 45 50

acc?acg?gcg?tat?ttg?cac?ccg?gat?ggt?tct?gat?gag?ttc?aag?ccg?att 307

Thr?Thr?Ala?Tyr?Leu?His?Pro?Asp?Gly?Ser?Asp?Glu?Phe?Lys?Pro?Ile

55 60 65

ctg?ggt?ggg?cgg?atg?cat?acg?cag?tat?ccg?gat?aat?gat?ttc?aag?agg 355

Leu?Gly?Gly?Arg?Met?His?Thr?Gln?Tyr?Pro?Asp?Asn?Asp?Phe?Lys?Arg

70 75 80 85

ttt?ttc?acc?tac?cgc?aac?cgt?ggc?tac?ctg?atg?agc?cag?ccg?gga?atg 403

Phe?Phe?Thr?Tyr?Arg?Asn?Arg?Gly?Tyr?Leu?Met?Ser?Gln?Pro?Gly?Met

90 95 100

cgc?aag?ctt?ctc?cct?cag?gaa?tat?gcg?cgc?ttt?gcg?tgg?ttc?ttc?ctg 451

Arg?Lys?Leu?Leu?Pro?Gln?Glu?Tyr?Ala?Arg?Phe?Ala?Trp?Phe?Phe?Leu

105 110 115

gtt?cag?aaa?cgg?gat?gtg?aag?gga?ttc?cgg?gag?tgg?ctg?cgc?ctg?cac 499

Val?Gln?Lys?Arg?Asp?Val?Lys?Gly?Phe?Arg?Glu?Trp?Leu?Arg?Leu?His

120 125 130

aaa?ctg?ggc?cgc?gac?gag?aaa?ttc?aat?agg?ccc?tagatcagtt?ttagtagttc?552

Lys?Leu?Gly?Arg?Asp?Glu?Lys?Phe?Asn?Arg?Pro

135 140

ctc 555

<210>456

<211>144

<212>PRT

＜213〉Corynebacterium glutamicum

<400>456

Leu?Leu?Pro?Gly?Ile?Ala?Ser?Leu?Phe?Asn?Gly?Ala?Leu?Ile?Ser?Ala

1 5 10 15

Tyr?Ala?Met?Glu?Arg?Ile?Gly?Val?Pro?Asp?Tyr?Arg?Leu?Phe?Ile?Arg

20 25 30

Gly?Asp?Glu?Val?Glu?Tyr?His?Arg?Arg?Leu?Val?Arg?Ser?Gly?Leu?Pro

35 40 45

Phe?Gly?Thr?Cys?Leu?Thr?Thr?Ala?Tyr?Leu?His?Pro?Asp?Gly?Ser?Asp

50 55 60

Glu?Phe?Lys?Pro?Ile?Leu?Gly?Gly?Arg?Met?His?Thr?Gln?Tyr?Pro?Asp

65 70 75 80

Asn?Asp?Phe?Lys?Arg?Phe?Phe?Thr?Tyr?Arg?Asn?Arg?Gly?Tyr?Leu?Met

85 90 95

Ser?Gln?Pro?Gly?Met?Arg?Lys?Leu?Leu?Pro?Gln?Glu?Tyr?Ala?Arg?Phe

100 105 110

Ala?Trp?Phe?Phe?Leu?Val?Gln?Lys?Arg?Asp?Val?Lys?Gly?Phe?Arg?Glu

115 120 125

Trp?Leu?Arg?Leu?His?Lys?Leu?Gly?Arg?Asp?Glu?Lys?Phe?Asn?Arg?Pro

130 135 140

<210>457

<211>507

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(484)

<223>RXA00327

<400>457

aacgattttc?gccgtcgcaa?ccgtgatcac?cggtcgcttt?ccggcatcgt?gtcgtcgcgg?60

ctagggggcc?aggcgcggga?tgattgggtt?tgtcacgccg?atg?att?cag?gcg?gcg 115

Met?Ile?Gln?Ala?Ala

1 5

ttg?tgg?atc?gtg?ctc?ttt?tta?ttc?gct?gat?cgc?ctg?tcc?aat?ccg?ctg 163

Leu?Trp?Ile?Val?Leu?Phe?Leu?Phe?Ala?Asp?Arg?Leu?Ser?Asn?Pro?Leu

10 15 20

gtt?ttt?gtc?agc?gcc?atc?atg?ttc?gcg?att?tcc?ttt?agc?tcc?ccc?gtg 211

Val?Phe?Val?Ser?Ala?Ile?Met?Phe?Ala?Ile?Ser?Phe?Ser?Ser?Pro?Val

25 30 35

gcg?aac?ttc?ggt?ttc?gat?acg?atc?tgc?gaa?aaa?ctc?gac?cgc?cgc?gtc 259

Ala?Asn?Phe?Gly?Phe?Asp?Thr?Ile?Cys?Glu?Lys?Leu?Asp?Arg?Arg?Val

40 45 50

atg?gtc?gcc?ggc?acc?ggc?atg?gcc?aac?atg?agc?gcc?tac?att?tgc?gcg 307

Met?Val?Ala?Gly?Thr?Gly?Met?Ala?Asn?Met?Ser?Ala?Tyr?Ile?Cys?Ala

55 60 65

atg?ctg?gcc?aca?caa?atc?atc?gga?ttt?tta?ctc?gac?tgg?aac?gcc?gac 355

Met?Leu?Ala?Thr?Gln?Ile?Ile?Gly?Phe?Leu?Leu?Asp?Trp?Asn?Ala?Asp

70 75 80 85

ggc?cac?gcc?tac?acc?tgg?tcg?aat?ttc?cag?gtg?gcg?tgg?ctt?ggt?ctg 403

Gly?His?Ala?Tyr?Thr?Trp?Ser?Asn?Phe?Gln?Val?Ala?Trp?Leu?Gly?Leu

90 95 100

ggc?gcg?gtg?tgg?ctg?gca?ggc?atg?atc?ggg?ctt?gca?gtc?tgc?ctc?ctg 451

Gly?Ala?Val?Trp?Leu?Ala?Gly?Met?Ile?Gly?Leu?Ala?Val?Cys?Leu?Leu

105 110 115

ctg?cag?cgt?cga?aaa?aat?att?gct?ttt?cga?cgc?taaaacccga?ccgtaaccgc?504

Leu?Gln?Arg?Arg?Lys?Asn?Ile?Ala?Phe?Arg?Arg

120 125

tag 507

<210>458

<211>128

<212>PRT

＜213〉Corynebacterium glutamicum

<400>458

Met?Ile?Gln?Ala?Ala?Leu?Trp?Ile?Val?Leu?Phe?Leu?Phe?Ala?Asp?Arg

1 5 10 15

Leu?Ser?Asn?Pro?Leu?Val?Phe?Val?Ser?Ala?Ile?Met?Phe?Ala?Ile?Ser

20 25 30

Phe?Ser?Ser?Pro?Val?Ala?Asn?Phe?Gly?Phe?Asp?Thr?Ile?Cys?Glu?Lys

35 40 45

Leu?Asp?Arg?Arg?Val?Met?Val?Ala?Gly?Thr?Gly?Met?Ala?Asn?Met?Ser

50 55 60

Ala?Tyr?Ile?Cys?Ala?Met?Leu?Ala?Thr?Gln?Ile?Ile?Gly?Phe?Leu?Leu

65 70 75 80

Asp?Trp?Asn?Ala?Asp?Gly?His?Ala?Tyr?Thr?Trp?Ser?Asn?Phe?Gln?Val

85 90 95

Ala?Trp?Leu?Gly?Leu?Gly?Ala?Val?Trp?Leu?Ala?Gly?Met?Ile?Gly?Leu

100 105 110

Ala?Val?Cys?Leu?Leu?Leu?Gln?Arg?Arg?Lys?Asn?Ile?Ala?Phe?Arg?Arg

115 120 125

<210>459

<211>615

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(592)

<223>RXA00328

<400>459

gtcacgggat?ttgttgtagc?ccgactcaag?ggtggaccgg?gccgcagatt?actcgcccag?60

attaggtcta?ccaaggactt?ttaaagatcg?ggtaaaacct?gtg?ggc?gtt?gaa?agg 115

Val?Gly?Val?Glu?Arg

1 5

ggc?aag?gtc?tct?gcc?aag?gca?cta?gtt?gtc?tgg?ttg?acg?gca?atg?tgc 163

Gly?Lys?Val?Ser?Ala?Lys?Ala?Leu?Val?Val?Trp?Leu?Thr?Ala?Met?Cys

10 15 20

gtg?tac?atc?gtg?gcc?att?gct?ggt?cga?aca?tca?ttt?ggt?gtc?gcc?gga 211

Val?Tyr?Ile?Val?Ala?Ile?Ala?Gly?Arg?Thr?Ser?Phe?Gly?Val?Ala?Gly

25 30 35

gtg?cat?gcg?atc?gat?cgc?ttt?gat?atc?gac?gcc?tcc?cgg?ttg?gcc?gtg 259

Val?His?Ala?Ile?Asp?Arg?Phe?Asp?Ile?Asp?Ala?Ser?Arg?Leu?Ala?Val

40 45 50

ttc?act?tct?gtt?cag?gtt?gga?gtc?tat?gtt?ctc?gcg?cag?att?ccc?atg 307

Phe?Thr?Ser?Val?Gln?Val?Gly?Val?Tyr?Val?Leu?Ala?Gln?Ile?Pro?Met

55 60 65

ggc?atg?ctg?gtg?gac?agg?ttc?gac?gcc?cgg?aaa?ctc?ttg?ctg?gct?ggc 355

Gly?Met?Leu?Val?Asp?Arg?Phe?Asp?Ala?Arg?Lys?Leu?Leu?Leu?Ala?Gly

70 75 80 85

gct?tta?att?ttg?gca?gct?ggc?cag?ctc?att?ttg?ggt?ttc?act?gat?tct 403

Ala?Leu?Ile?Leu?Ala?Ala?Gly?Gln?Leu?Ile?Leu?Gly?Phe?Thr?Asp?Ser

90 95 100

tat?atg?atc?gcc?att?ttt?gcc?cga?gtg?ctc?atc?agt?gtt?ggc?gat?tct 451

Tyr?Met?Ile?Ala?Ile?Phe?Ala?Arg?Val?Leu?Ile?Ser?Val?Gly?Asp?Ser

105 110 115

tct?gca?ttt?ttg?tcc?gtg?atg?cga?ctg?ttg?ccc?aac?tgg?ttc?ccg?atg 499

Ser?Ala?Phe?Leu?Ser?Val?Met?Arg?Leu?Leu?Pro?Asn?Trp?Phe?Pro?Met

120 125 130

tct?tgg?aca?cct?gtg?ttg?cag?cag?ctc?acg?ggc?gct?ttt?ggc?ttt?gtg 547

Ser?Trp?Thr?Pro?Val?Leu?Gln?Gln?Leu?Thr?Gly?Ala?Phe?Gly?Phe?Val

135 140 145

ggg?cag?ttt?tct?ccg?cgg?tgc?cgt?ttt?tgc?aca?tac?tca?aca?cct 592

Gly?Gln?Phe?Ser?Pro?Arg?Cys?Arg?Phe?Cys?Thr?Tyr?Ser?Thr?Pro

150 155 160

tagggtggac?aattcctttc?gca 615

<210>460

<211>164

<212>PRT

＜213〉Corynebacterium glutamicum

<400>460

Val?Gly?Val?Glu?Arg?Gly?Lys?Val?Ser?Ala?Lys?Ala?Leu?Val?Val?Trp

1 5 10 15

Leu?Thr?Ala?Met?Cys?Val?Tyr?Ile?Val?Ala?Ile?Ala?Gly?Arg?Thr?Ser

20 25 30

Phe?Gly?Val?Ala?Gly?Val?His?Ala?Ile?Asp?Arg?Phe?Asp?Ile?Asp?Ala

35 40 45

Ser?Arg?Leu?Ala?Val?Phe?Thr?Ser?Val?Gln?Val?Gly?Val?Tyr?Val?Leu

50 55 60

Ala?Gln?Ile?Pro?Met?Gly?Met?Leu?Val?Asp?Arg?Phe?Asp?Ala?Arg?Lys

65 70 75 80

Leu?Leu?Leu?Ala?Gly?Ala?Leu?Ile?Leu?Ala?Ala?Gly?Gln?Leu?Ile?Leu

85 90 95

Gly?Phe?Thr?Asp?Ser?Tyr?Met?Ile?Ala?Ile?Phe?Ala?Arg?Val?Leu?Ile

100 105 110

Ser?Val?Gly?Asp?Ser?Ser?Ala?Phe?Leu?Ser?Val?Met?Arg?Leu?Leu?Pro

115 120 125

Asn?Trp?Phe?Pro?Met?Ser?Trp?Thr?Pro?Val?Leu?Gln?Gln?Leu?Thr?Gly

130 135 140

Ala?Phe?Gly?Phe?Val?Gly?Gln?Phe?Ser?Pro?Arg?Cys?Arg?Phe?Cys?Thr

145 150 155 160

Tyr?Ser?Thr?Pro

<210>461

<211>1347

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1324)

<223>RXA00329

<400>461

tgtgaagaac?aatgatcaac?ggccttcgcc?aagaccgcat?cccagagaga?aagtaactac?60

ccgcgccctc?atagtttggg?cagcagcctg?tcttgtgtat?atg?gca?gcc?att?acc 115

Met?Ala?Ala?Ile?Thr

1 5

agc?cgc?acc?agc?ttt?ggt?gtg?gct?gga?gtg?gag?gcc?att?gat?cgt?ttt 163

Ser?Arg?Thr?Ser?Phe?Gly?Val?Ala?Gly?Val?Glu?Ala?Ile?Asp?Arg?Phe

10 15 20

cag?gta?gac?gcc?aca?cgc?att?gca?gta?ttc?act?tct?gtt?cag?gtt?ggt 211

Gln?Val?Asp?Ala?Thr?Arg?Ile?Ala?Val?Phe?Thr?Ser?Val?Gln?Val?Gly

25 30 35

gtg?tac?gcg?ttt?gct?cag?att?ccg?atg?ggc?att?ttg?atc?gat?aag?ttt 259

Val?Tyr?Ala?Phe?Ala?Gln?Ile?Pro?Met?Gly?Ile?Leu?Ile?Asp?Lys?Phe

40 45 50

ggt?cct?cgg?aag?ctc?ctt?gcc?att?ggt?gct?ttg?gtg?atg?ggt?atc?ggc 307

Gly?Pro?Arg?Lys?Leu?Leu?Ala?Ile?Gly?Ala?Leu?Val?Met?Gly?Ile?Gly

55 60 65

cag?ctc?att?ttg?ggc?ttt?acg?gat?agc?tat?tcc?atc?gcg?att?att?gcc 355

Gln?Leu?Ile?Leu?Gly?Phe?Thr?Asp?Ser?Tyr?Ser?Ile?Ala?Ile?Ile?Ala

70 75 80 85

cgc?gtg?ttt?atc?ggc?gcc?ggc?gat?gca?tcg?atc?ttc?ctt?tcg?gtt?atg 403

Arg?Val?Phe?Ile?Gly?Ala?Gly?Asp?Ala?Ser?Ile?Phe?Leu?Ser?Val?Met

90 95 100

cgc?atc?ctg?ccg?ttt?tgg?ttc?cca?ctg?aag?cac?acc?cct?att?ttc?acg 451

Arg?Ile?Leu?Pro?Phe?Trp?Phe?Pro?Leu?Lys?His?Thr?Pro?Ile?Phe?Thr

105 110 115

cag?tta?act?acc?tgc?ctt?ggc?cag?ttg?ggc?cag?ttc?ttt?tct?gcg?gtg 499

Gln?Leu?Thr?Thr?Cys?Leu?Gly?Gln?Leu?Gly?Gln?Phe?Phe?Ser?Ala?Val

120 125 130

cct?ttc?atg?gcg?ttg?ttg?ggt?gcg?cag?ggt?tgg?cct?gtg?gcg?ttt?gtc 547

Pro?Phe?Met?Ala?Leu?Leu?Gly?Ala?Gln?Gly?Trp?Pro?Val?Ala?Phe?Val

135 140 145

agc?ctt?ggt?tcc?gtg?gtg?gca?ctc?att?gcg?atc?gca?gcg?ctg?gtg?gcc 595

Ser?Leu?Gly?Ser?Val?Val?Ala?Leu?Ile?Ala?Ile?Ala?Ala?Leu?Val?Ala

150 155 160 165

gtt?cgg?gat?act?cca?gat?cct?cag?cca?aaa?cct?gtc?gaa?tca?gct?cag 643

Val?Arg?Asp?Thr?Pro?Asp?Pro?Gln?Pro?Lys?Pro?Val?Glu?Ser?Ala?Gln

170 175 180

gaa?gca?gat?aaa?cca?agc?ctg?cgc?gcg?agt?ttg?aag?ttg?att?gtc?cgc 691

Glu?Ala?Asp?Lys?Pro?Ser?Leu?Arg?Ala?Ser?Leu?Lys?Leu?Ile?Val?Arg

185 190 195

aat?ccg?att?acg?tgg?cag?ggt?ttc?ttc?att?cac?tac?gta?ttg?atg?gtg 739

Asn?Pro?Ile?Thr?Trp?Gln?Gly?Phe?Phe?Ile?His?Tyr?Val?Leu?Met?Val

200 205 210

tgg?cag?acc?gtg?ttc?tcc?atg?atg?tgg?ggc?gtc?ccg?ctg?atg?act?ttg 787

Trp?Gln?Thr?Val?Phe?Ser?Met?Met?Trp?Gly?Val?Pro?Leu?Met?Thr?Leu

215 220 225

ggc?atg?gga?ctg?tct?gca?acg?acg?gct?ggt?ttg?gtg?ttg?agc?atc?aac 835

Gly?Met?Gly?Leu?Ser?Ala?Thr?Thr?Ala?Gly?Leu?Val?Leu?Ser?Ile?Asn

230 235 240 245

acg?ctg?tgc?atg?gtg?gta?tcg?gcg?cca?atc?atc?gga?ata?att?tcc?gca 883

Thr?Leu?Cys?Met?Val?Val?Ser?Ala?Pro?Ile?Ile?Gly?Ile?Ile?Ser?Ala

250 255 260

cgc?ctt?ggg?tat?cgc?cgt?gac?gtg?gtc?gcc?att?gcg?ctg?tcg?ttt?gtt 931

Arg?Leu?Gly?Tyr?Arg?Arg?Asp?Val?Val?Ala?Ile?Ala?Leu?Ser?Phe?Val

265 270 275

caa?tcc?gca?gta?tgg?ctg?gtg?ttc?ttg?gcc?tcc?gat?gca?cct?cgt?ggt 979

Gln?Ser?Ala?Val?Trp?Leu?Val?Phe?Leu?Ala?Ser?Asp?Ala?Pro?Arg?Gly

280 285 290

ttg?atg?gct?atc?atc?ttg?gtc?aac?atc?gtc?atg?ggt?ctg?act?act?gcg 1027

Leu?Met?Ala?Ile?Ile?Leu?Val?Asn?Ile?Val?Met?Gly?Leu?Thr?Thr?Ala

295 300 305

gct?tct?ggt?tat?ggc?ttt?gac?acc?att?cgt?gag?cgc?cta?gat?cgc?aag 1075

Ala?Ser?Gly?Tyr?Gly?Phe?Asp?Thr?Ile?Arg?Glu?Arg?Leu?Asp?Arg?Lys

310 315 320 325

att?ttg?gct?gcg?ggc?acg?gga?ctg?gca?aac?atg?ggt?gga?ttc?ttg?tca 1123

Ile?Leu?Ala?Ala?Gly?Thr?Gly?Leu?Ala?Asn?Met?Gly?Gly?Phe?Leu?Ser

330 335 340

tcg?atg?gtt?gca?gcg?cag?gtt?atg?ggg?ttc?ctt?ctt?gat?cac?agc?gcg 1171

Ser?Met?Val?Ala?Ala?Gln?Val?Met?Gly?Phe?Leu?Leu?Asp?His?Ser?Ala

345 350 355

cat?ggt?agc?acc?tat?act?tgg?gtg?gac?ttc?cgt?ttt?ggt?ttc?ctt?gcg 1219

His?Gly?Ser?Thr?Tyr?Thr?Trp?Val?Asp?Phe?Arg?Phe?Gly?Phe?Leu?Ala

360 365 370

att?ctt?gtc?aca?tgg?gcc?gtc?gga?gtc?acg?gga?ttt?gtt?gta?gcc?cga 1267

Ile?Leu?Val?Thr?Trp?Ala?Val?Gly?Val?Thr?Gly?Phe?Val?Val?Ala?Arg

375 380 385

ctc?aag?ggt?gga?ccg?ggc?cgc?aga?tta?ctc?gcc?cag?att?agg?tct?acc 1315

Leu?Lys?Gly?Gly?Pro?Gly?Arg?Arg?Leu?Leu?Ala?Gln?Ile?Arg?Ser?Thr

390 395 400 405

aag?gac?ttt?taaagatcgg?gtaaaacctg?tgg 1347

Lys?Asp?Phe

<210>462

<211>408

<212>PRT

＜213〉Corynebacterium glutamicum

<400>462

Met?Ala?Ala?Ile?Thr?Ser?Arg?Thr?Ser?Phe?Gly?Val?Ala?Gly?Val?Glu

1 5 10 15

Ala?Ile?Asp?Arg?Phe?Gln?Val?Asp?Ala?Thr?Arg?Ile?Ala?Val?Phe?Thr

20 25 30

Ser?Val?Gln?Val?Gly?Val?Tyr?Ala?Phe?Ala?Gln?Ile?Pro?Met?Gly?Ile

35 40 45

Leu?Ile?Asp?Lys?Phe?Gly?Pro?Arg?Lys?Leu?Leu?Ala?Ile?Gly?Ala?Leu

50 55 60

Val?Met?Gly?Ile?Gly?Gln?Leu?Ile?Leu?Gly?Phe?Thr?Asp?Ser?Tyr?Ser

65 70 75 80

Ile?Ala?Ile?Ile?Ala?Arg?Val?Phe?lle?Gly?Ala?Gly?Asp?Ala?Ser?Ile

85 90 95

Phe?Leu?Ser?Val?Met?Arg?Ile?Leu?Pro?Phe?Trp?Phe?Pro?Leu?Lys?His

100 105 110

Thr?Pro?Ile?Phe?Thr?Gln?Leu?Thr?Thr?Cys?Leu?Gly?Gln?Leu?Gly?Gln

115 120 125

Phe?Phe?Ser?Ala?Val?Pro?Phe?Met?Ala?Leu?Leu?Gly?Ala?Gln?Gly?Trp

130 135 140

Pro?Val?Ala?Phe?Val?Ser?Leu?Gly?Ser?Val?Val?Ala?Leu?Ile?Ala?Ile

145 150 155 160

Ala?Ala?Leu?Val?Ala?Val?Arg?Asp?Thr?Pro?Asp?Pro?Gln?Pro?Lys?Pro

165 170 175

Val?Glu?Ser?Ala?Gln?Glu?Ala?Asp?Lys?Pro?Ser?Leu?Arg?Ala?Ser?Leu

180 185 190

Lys?Leu?Ile?Val?Arg?Asn?Pro?Ile?Thr?Trp?Gln?Gly?Phe?Phe?Ile?His

195 200 205

Tyr?Val?Leu?Met?Val?Trp?Gln?Thr?Val?Phe?Ser?Met?Met?Trp?Gly?Val

210 215 220

Pro?Leu?Met?Thr?Leu?Gly?Met?Gly?Leu?Ser?Ala?Thr?Thr?Ala?Gly?Leu

225 230 235 240

Val?Leu?Ser?Ile?Asn?Thr?Leu?Cys?Met?Val?Val?Ser?Ala?Pro?Ile?Ile

245 250 255

Gly?Ile?Ile?Ser?Ala?Arg?Leu?Gly?Tyr?Arg?Arg?Asp?Val?Val?Ala?Ile

260 265 270

Ala?Leu?Ser?Phe?Val?Gln?Ser?Ala?Val?Trp?Leu?Val?Phe?Leu?Ala?Ser

275 280 285

Asp?Ala?Pro?Arg?Gly?Leu?Met?Ala?Ile?Ile?Leu?Val?Asn?Ile?Val?Met

290 295 300

Gly?Leu?Thr?Thr?Ala?Ala?Ser?Gly?Tyr?Gly?Phe?Asp?Thr?Ile?Arg?Glu

305 310 315 320

Arg?Leu?Asp?Arg?Lys?Ile?Leu?Ala?Ala?Gly?Thr?Gly?Leu?Ala?Asn?Met

325 330 335

Gly?Gly?Phe?Leu?Ser?Ser?Met?Val?Ala?Ala?Gln?Val?Met?Gly?Phe?Leu

340 345 350

Leu?Asp?His?Ser?Ala?His?Gly?Ser?Thr?Tyr?Thr?Trp?Val?Asp?Phe?Arg

355 360 365

Phe?Gly?Phe?Leu?Ala?Ile?Leu?Val?Thr?Trp?Ala?Val?Gly?Val?Thr?Gly

370 375 380

Phe?Val?Val?Ala?Arg?Leu?Lys?Gly?Gly?Pro?Gly?Arg?Arg?Leu?Leu?Ala

385 390 395 400

Gln?Ile?Arg?Ser?Thr?Lys?Asp?Phe

405

<210>463

<211>2265

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(2242)

<223>RXN01554

<400>463

tggcttaaac?cttatttgta?gttgtcaata?aatatgaaat?tccttagcaa?cttgtttaaa?60

tagacgtata?aacaagtttg?aaaaaggaag?gttatccatc?ttg?aaa?aag?cat?gtg 115

Leu?Lys?Lys?His?Val

1 5

acc?tca?gcc?gtt?acc?gcc?gtg?gtg?acg?gct?ttt?tca?acg?gct?gcg?ctt 163

Thr?Ser?Ala?Val?Thr?Ala?Val?Val?Thr?Ala?Phe?Ser?Thr?Ala?Ala?Leu

10 15 20

ggt?tta?agt?att?gcc?gtt?tct?cct?gct?gtt?gcc?caa?gtg?gct?aat?cca 211

Gly?Leu?Ser?Ile?Ala?Val?Ser?Pro?Ala?Val?Ala?Gln?Val?Ala?Asn?Pro

25 30 35

gct?cca?gat?ctt?tct?gcg?ccg?tat?aca?tgg?gtg?gaa?gag?ttt?gat?tcc 259

Ala?Pro?Asp?Leu?Ser?Ala?Pro?Tyr?Thr?Trp?Val?Glu?Glu?Phe?Asp?Ser

40 45 50

gag?gat?gct?ctc?aaa?ggg?tgg?aac?att?ttc?cgc?cag?cca?gat?tat?ggc 307

Glu?Asp?Ala?Leu?Lys?Gly?Trp?Asn?Ile?Phe?Arg?Gln?Pro?Asp?Tyr?Gly

55 60 65

agc?gac?aaa?gtt?ctc?tat?acc?gaa?gat?gct?tta?agt?atc?gaa?gat?ggc 355

Ser?Asp?Lys?Val?Leu?Tyr?Thr?Glu?Asp?Ala?Leu?Ser?Ile?Glu?Asp?Gly

70 75 80 85

aag?ctc?acc?atc?acc?act?cag?cgc?cac?tgc?gtt?gac?gaa?gac?ttc?gcg 403

Lys?Leu?Thr?Ile?Thr?Thr?Gln?Arg?His?Cys?Val?Asp?Glu?Asp?Phe?Ala

90 95 100

atc?agt?gat?cct?gtc?aac?cgc?gga?aag?ctc?aat?gac?agc?acc?gcg?caa 451

Ile?Ser?Asp?Pro?Val?Asn?Arg?Gly?Lys?Leu?Asn?Asp?Ser?Thr?Ala?Gln

105 110 115

gtt?gaa?cct?tgt?gct?cca?ggt?cag?ttt?gaa?aag?ttc?acc?agt?gcg?cgc 499

Val?Glu?Pro?Cys?Ala?Pro?Gly?Gln?Phe?Glu?Lys?Phe?Thr?Ser?Ala?Arg

120 125 130

atc?gtc?act?ccg?aaa?att?gct?cgt?gga?gag?ttc?gac?ctt?tct?gtc?act 547

Ile?Val?Thr?Pro?Lys?Ile?Ala?Arg?Gly?Glu?Phe?Asp?Leu?Ser?Val?Thr

135 140 145

gca?act?ctt?aac?acc?ggt?ggc?gtc?gaa?ggt?gtc?cga?agt?gcc?att?tgg 595

Ala?Thr?Leu?Asn?Thr?Gly?Gly?Val?Glu?Gly?Val?Arg?Ser?Ala?Ile?Trp

150 155 160 165

atg?caa?aac?ggt?gaa?cag?gcg?tgt?tcc?tca?gca?acc?aac?aat?ggc?ctc 643

Met?Gln?Asn?Gly?Glu?Gln?Ala?Cys?Ser?Ser?Ala?Thr?Asn?Asn?Gly?Leu

170 175 180

tac?gga?gaa?cta?gac?ctg?gta?gag?cac?ttt?tct?tac?gat?ctt?cgc?tcg 691

Tyr?Gly?Glu?Leu?Asp?Leu?Val?Glu?His?Phe?Ser?Tyr?Asp?Leu?Arg?Ser

185 190 195

cca?tgg?tct?cca?tca?aac?acc?cac?ttg?ggt?tgt?gat?cct?gaa?agt?gtc 739

Pro?Trp?Ser?Pro?Ser?Asn?Thr?His?Leu?Gly?Cys?Asp?Pro?Glu?Ser?Val

200 205 210

aac?ggc?acc?aac?cgt?gca?cct?cgt?gaa?ctt?aaa?cta?gat?gag?tca?ctc 787

Asn?Gly?Thr?Asn?Arg?Ala?Pro?Arg?Glu?Leu?Lys?Leu?Asp?Glu?Ser?Leu

215 220 225

gat?ggc?gtg?gag?cac?acc?tgg?act?gtg?agc?acc?acc?cgc?gac?ggc?gtt 835

Asp?Gly?Val?Glu?His?Thr?Trp?Thr?Val?Ser?Thr?Thr?Arg?Asp?Gly?Val

230 235 240 245

gag?tac?ttc?att?gat?gat?gag?gcg?att?aac?cgc?cag?tca?tgg?cgc?aac 883

Glu?Tyr?Phe?Ile?Asp?Asp?Glu?Ala?Ile?Asn?Arg?Gln?Ser?Trp?Arg?Asn

250 255 260

gat?gtc?act?ttg?ggg?cat?gcc?gaa?att?gat?gat?ttc?ggg?atc?tcc?gcg 931

Asp?Val?Thr?Leu?Gly?His?Ala?Glu?Ile?Asp?Asp?Phe?Gly?Ile?Ser?Ala

265 270 275

cag?acg?ttt?gat?gag?atc?gtc?gac?cgc?gaa?tgg?act?ctc?act?ctt?aat 979

Gln?Thr?Phe?Asp?Glu?Ile?Val?Asp?Arg?Glu?Trp?Thr?Leu?Thr?Leu?Asn

280 285 290

caa?aag?gta?gaa?agc?gcc?gac?tgg?gca?aaa?cca?cgt?tcc?tct?gag?gaa 1027

Gln?Lys?Val?Glu?Ser?Ala?Asp?Trp?Ala?Lys?Pro?Arg?Ser?Ser?Glu?Glu

295 300 305

gat?ttc?cca?gtc?cgg?tcc?atg?gtg?att?gac?cgc?atc?gag?gtc?acc?gga 1075

Asp?Phe?Pro?Val?Arg?Ser?Met?Val?Ile?Asp?Arg?Ile?Glu?Val?Thr?Gly

310 315 320 325

tct?ccc?gca?gta?tct?gaa?gac?acc?ccc?atg?cca?gat?acc?acc?cag?ctt 1123

Ser?Pro?Ala?Val?Ser?Glu?Asp?Thr?Pro?Met?Pro?Asp?Thr?Thr?Gln?Leu

330 335 340

ttg?acc?caa?gac?act?ctg?gaa?tac?ctc?ggt?cgc?atg?cca?gtg?ctg?gaa 1171

Leu?Thr?Gln?Asp?Thr?Leu?Glu?Tyr?Leu?Gly?Arg?Met?Pro?Val?Leu?Glu

345 350 355

cgc?tac?gag?cca?gca?agt?gct?gat?ttt?gcc?gat?ggc?cgc?agg?cct?tcc 1219

Arg?Tyr?Glu?Pro?Ala?Ser?Ala?Asp?Phe?Ala?Asp?Gly?Arg?Arg?Pro?Ser

360 365 370

tgg?aac?tac?ttc?aat?ttg?aag?gaa?tcg?tgg?cag?aat?cca?gaa?ctc?gag 1267

Trp?Asn?Tyr?Phe?Asn?Leu?Lys?Glu?Ser?Trp?Gln?Asn?Pro?Glu?Leu?Glu

375 380 385

caa?cgc?cca?gaa?gct?gtc?gaa?ttc?gtt?gat?gga?cgc?atg?gat?atc?gtg 1315

Gln?Arg?Pro?Glu?Ala?Val?Glu?Phe?Val?Asp?Gly?Arg?Met?Asp?Ile?Val

390 395 400 405

acc?cgt?cgc?cac?tgt?ctg?gcc?acc?act?gat?gac?atc?gcc?act?ccg?gaa 1363

Thr?Arg?Arg?His?Cys?Leu?Ala?Thr?Thr?Asp?Asp?Ile?Ala?Thr?Pro?Glu

410 415 420

aac?gca?cag?gag?gaa?ccg?tgc?gcg?ccg?ggt?gag?gtg?aca?cgc?tac?agc 1411

Asn?Ala?Gln?Glu?Glu?Pro?Cys?Ala?Pro?Gly?Glu?Val?Thr?Arg?Tyr?Ser

425 430 435

tca?gcg?cgt?gtc?cac?ctt?cca?gag?atc?ccc?gcc?ggc?aac?ttc?cgg?ctc 1459

Ser?Ala?Arg?Val?His?Leu?Pro?Glu?Ile?Pro?Ala?Gly?Asn?Phe?Arg?Leu

440 445 450

acc?gtg?cgc?gca?cgg?gcg?cag?tcc?gaa?gag?ctt?gtc?gac?ggc?gtc?cgc 1507

Thr?Val?Arg?Ala?Arg?Ala?Gln?Ser?Glu?Glu?Leu?Val?Asp?Gly?Val?Arg

455 460 465

ccc?gct?atc?tgg?atg?cag?aac?aat?acc?aac?ttc?tgt?gct?gac?aac?gat 1555

Pro?Ala?Ile?Trp?Met?Gln?Asn?Asn?Thr?Asn?Phe?Cys?Ala?Asp?Asn?Asp

470 475 480 485

gga?cgc?cct?tat?ggt?gaa?ctg?gat?att?act?gag?ttc?tac?agc?tct?cgt 1603

Gly?Arg?Pro?Tyr?Gly?Glu?Leu?Asp?Ile?Thr?Glu?Phe?Tyr?Ser?Ser?Arg

490 495 500

gtg?aac?acc?cag?tac?tcg?gca?gta?cac?ctt?gga?tgt?gct?ggc?aac?cgc 1651

Val?Asn?Thr?Gln?Tyr?Ser?Ala?Val?His?Leu?Gly?Cys?Ala?Gly?Asn?Arg

505 510 515

cca?gag?atg?aag?ctt?cgc?caa?atg?gaa?atg?gaa?gag?tcc?atg?ttt?ggg 1699

Pro?Glu?Met?Lys?Leu?Arg?Gln?Met?Glu?Met?Glu?Glu?Ser?Met?Phe?Gly

520 525 530

gat?tgg?cat?gac?tgg?ggc?gtc?gaa?gtc?ttc?gac?ggc?cag?atc?gta?ttc 1747

Asp?Trp?His?Asp?Trp?Gly?Val?Glu?Val?Phe?Asp?Gly?Gln?Ile?Val?Phe

535 540 545

acc?att?gac?ggc?aag?gca?gta?act?tcc?tct?ggc?aaa?gat?gtc?ttt?ggc 1795

Thr?Ile?Asp?Gly?Lys?Ala?Val?Thr?Ser?Ser?Gly?Lys?Asp?Val?Phe?Gly

550 555 560 565

aac?tct?gtt?acc?cca?gcc?gct?gca?cct?ctt?cgc?ccc?gcg?cac?ttc?aag 1843

Asn?Ser?Val?Thr?Pro?Ala?Ala?Ala?Pro?Leu?Arg?Pro?Ala?His?Phe?Lys

570 575 580

ttg?tcg?gaa?gag?gaa?tac?cgt?gaa?gtc?atc?ggg?cag?cct?tgg?cac?ctt 1891

Leu?Ser?Glu?Glu?Glu?Tyr?Arg?Glu?Val?Ile?Gly?Gln?Pro?Trp?His?Leu

585 590 595

att?ttg?aac?acc?atg?gtg?gag?cag?tct?ggc?aaa?gac?agc?tgg?att?aca 1939

Ile?Leu?Asn?Thr?Met?Val?Glu?Gln?Ser?Gly?Lys?Asp?Ser?Trp?Ile?Thr

600 605 610

gcg?gtc?gac?aat?aac?gag?gcg?ttc?cca?gaa?cac?cgc?ttc?caa?att?gac 1987

Ala?Val?Asp?Asn?Asn?Glu?Ala?Phe?Pro?Glu?His?Arg?Phe?Gln?Ile?Asp

615 620 625

cat?gtg?gca?gta?gat?atc?gag?tct?gac?tct?gtg?gac?aat?gta?tgg?cct 2035

His?Val?Ala?Val?Asp?Ile?Glu?Ser?Asp?Ser?Val?Asp?Asn?Val?Trp?Pro

630 635 640 645

gac?gct?gcg?aat?gaa?atc?cca?gac?aat?gtt?ggt?att?gaa?gac?tct?gat 2083

Asp?Ala?Ala?Asn?Glu?Ile?Pro?Asp?Asn?Val?Gly?Ile?Glu?Asp?Ser?Asp

650 655 660

gat?ggc?agc?gac?ctg?gag?gtt?ggt?tcg?acc?gga?agc?tct?aca?gct?gag 2131

Asp?Gly?Ser?Asp?Leu?Glu?Val?Gly?Ser?Thr?Gly?Ser?Ser?Thr?Ala?Glu

665 670 675

acc?gtg?agc?tgg?atc?tcg?ttg?ttc?acc?gcg?ttg?agc?tcg?ctg?gtc?ttc 2179

Thr?Val?Ser?Trp?Ile?Ser?Leu?Phe?Thr?Ala?Leu?Ser?Ser?Leu?Val?Phe

680 685 690

aca?ctg?gct?ctc?aat?caa?gaa?gca?ttg?cag?aat?ttg?att?aat?cag?ttc 2227

Thr?Leu?Ala?Leu?Asn?Gln?Glu?Ala?Leu?Gln?Asn?Leu?Ile?Asn?Gln?Phe

695 700 705

atg?aga?cag?ttc?aag?taatccttgt?gggcgctttg?tct 2265

Met?Arg?Gln?Phe?Lys

710

<210>464

<211>714

<212>PRT

＜213〉Corynebacterium glutamicum

<400>464

Leu?Lys?Lys?His?Val?Thr?Ser?Ala?Val?Thr?Ala?Val?Val?Thr?Ala?Phe

1 5 10 15

Ser?Thr?Ala?Ala?Leu?Gly?Leu?Ser?Ile?Ala?Val?Ser?Pro?Ala?Val?Ala

20 25 30

Gln?Val?Ala?Asn?Pro?Ala?Pro?Asp?Leu?Ser?Ala?Pro?Tyr?Thr?Trp?Val

35 40 45

Glu?Glu?Phe?Asp?Ser?Glu?Asp?Ala?Leu?Lys?Gly?Trp?Asn?Ile?Phe?Arg

50 55 60

Gln?Pro?Asp?Tyr?Gly?Ser?Asp?Lys?Val?Leu?Tyr?Thr?Glu?Asp?Ala?Leu

65 70 75 80

Ser?Ile?Glu?Asp?Gly?Lys?Leu?Thr?Ile?Thr?Thr?Gln?Arg?His?Cys?Val

85 90 95

Asp?Glu?Asp?Phe?Ala?Ile?Ser?Asp?Pro?Val?Asn?Arg?Gly?Lys?Leu?Asn

100 105 110

Asp?Ser?Thr?Ala?Gln?Val?Glu?Pro?Cys?Ala?Pro?Gly?Gln?Phe?Glu?Lys

115 120 125

Phe?Thr?Ser?Ala?Arg?Ile?Val?Thr?Pro?Lys?Ile?Ala?Arg?Gly?Glu?Phe

130 135 140

Asp?Leu?Ser?Val?Thr?Ala?Thr?Leu?Asn?Thr?Gly?Gly?Val?Glu?Gly?Val

145 150 155 160

Arg?Ser?Ala?Ile?Trp?Met?Gln?Asn?Gly?Glu?Gln?Ala?Cys?Ser?Ser?Ala

165 170 175

Thr?Asn?Asn?Gly?Leu?Tyr?Gly?Glu?Leu?Asp?Leu?Val?Glu?His?Phe?Ser

180 185 190

Tyr?Asp?Leu?Arg?Ser?Pro?Trp?Ser?Pro?Ser?Asn?Thr?His?Leu?Gly?Cys

195 200 205

Asp?Pro?Glu?Ser?Val?Asn?Gly?Thr?Asn?Arg?Ala?Pro?Arg?Glu?Leu?Lys

210 215 220

Leu?Asp?Glu?Ser?Leu?Asp?Gly?Val?Glu?His?Thr?Trp?Thr?Val?Ser?Thr

225 230 235 240

Thr?Arg?Asp?Gly?Val?Glu?Tyr?Phe?Ile?Asp?Asp?Glu?Ala?Ile?Asn?Arg

245 250 255

Gln?Ser?Trp?Arg?Asn?Asp?Val?Thr?Leu?Gly?His?Ala?Glu?Ile?Asp?Asp

260 265 270

Phe?Gly?Ile?Ser?Ala?Gln?Thr?Phe?Asp?Glu?Ile?Val?Asp?Arg?Glu?Trp

275 280 285

Thr?Leu?Thr?Leu?Asn?Gln?Lys?Val?Glu?Ser?Ala?Asp?Trp?Ala?Lys?Pro

290 295 300

Arg?Ser?Ser?Glu?Glu?Asp?Phe?Pro?Val?Arg?Ser?Met?Val?Ile?Asp?Arg

305 310 315 320

Ile?Glu?Val?Thr?Gly?Ser?Pro?Ala?Val?Ser?Glu?Asp?Thr?Pro?Met?Pro

325 330 335

Asp?Thr?Thr?Gln?Leu?Leu?Thr?Gln?Asp?Thr?Leu?Glu?Tyr?Leu?Gly?Arg

340 345 350

Met?Pro?Val?Leu?Glu?Arg?Tyr?Glu?Pro?Ala?Ser?Ala?Asp?Phe?Ala?Asp

355 360 365

Gly?Arg?Arg?Pro?Ser?Trp?Asn?Tyr?Phe?Asn?Leu?Lys?Glu?Ser?Trp?Gln

370 375 380

Asn?Pro?Glu?Leu?Glu?Gln?Arg?Pro?Glu?Ala?Val?Glu?Phe?Val?Asp?Gly

385 390 395 400

Arg?Met?Asp?Ile?Val?Thr?Arg?Arg?His?Cys?Leu?Ala?Thr?Thr?Asp?Asp

405 410 415

Ile?Ala?Thr?Pro?Glu?Asn?Ala?Gln?Glu?Glu?Pro?Cys?Ala?Pro?Gly?Glu

420 425 430

Val?Thr?Arg?Tyr?Ser?Ser?Ala?Arg?Val?His?Leu?Pro?Glu?Ile?Pro?Ala

435 440 445

Gly?Asn?Phe?Arg?Leu?Thr?Val?Arg?Ala?Arg?Ala?Gln?Ser?Glu?Glu?Leu

450 455 460

Val?Asp?Gly?Val?Arg?Pro?Ala?Ile?Trp?Met?Gln?Asn?Asn?Thr?Asn?Phe

465 470 475 480

Cys?Ala?Asp?Asn?Asp?Gly?Arg?Pro?Tyr?Gly?Glu?Leu?Asp?Ile?Thr?Glu

485 490 495

Phe?Tyr?Ser?Ser?Arg?Val?Asn?Thr?Gln?Tyr?Ser?Ala?Val?His?Leu?Gly

500 505 510

Cys?Ala?Gly?Asn?Arg?Pro?Glu?Met?Lys?Leu?Arg?Gln?Met?Glu?Met?Glu

515 520 525

Glu?Ser?Met?Phe?Gly?Asp?Trp?His?Asp?Trp?Gly?Val?Glu?Val?Phe?Asp

530 535 540

Gly?Gln?Ile?Val?Phe?Thr?Ile?Asp?Gly?Lys?Ala?Val?Thr?Ser?Ser?Gly

545 550 555 560

Lys?Asp?Val?Phe?Gly?Asn?Ser?Val?Thr?Pro?Ala?Ala?Ala?Pro?Leu?Arg

565 570 575

Pro?Ala?His?Phe?Lys?Leu?Ser?Glu?Glu?Glu?Tyr?Arg?Glu?Val?Ile?Gly

580 585 590

Gln?Pro?Trp?His?Leu?Ile?Leu?Asn?Thr?Met?Val?Glu?Gln?Ser?Gly?Lys

595 600 605

Asp?Ser?Trp?Ile?Thr?Ala?Val?Asp?Asn?Asn?Glu?Ala?Phe?Pro?Glu?His

610 615 620

Arg?Phe?Gln?Ile?Asp?His?Val?Ala?Val?Asp?Ile?Glu?Ser?Asp?Ser?Val

625 630 635 640

Asp?Asn?Val?Trp?Pro?Asp?Ala?Ala?Asn?Glu?Ile?Pro?Asp?Asn?Val?Gly

645 650 655

Ile?Glu?Asp?Ser?Asp?Asp?Gly?Ser?Asp?Leu?Glu?Val?Gly?Ser?Thr?Gly

660 665 670

Ser?Ser?Thr?Ala?Glu?Thr?Val?Ser?Trp?Ile?Ser?Leu?Phe?Thr?Ala?Leu

675 680 685

Ser?Ser?Leu?Val?Phe?Thr?Leu?Ala?Leu?Asn?Gln?Glu?Ala?Leu?Gln?Asn

690 695 700

Leu?Ile?Asn?Gln?Phe?Met?Arg?Gln?Phe?Lys

705 710

<210>465

<21l>389

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(382)

<223>RXN03015

<400>465

ccgggtttgc?ctgaggtttt?ggagcgcaat?ctggaaaatg?gtcgcctgaa?cttcactact?60

gattatgcgg?aggctgcggc?tttcgcgcag?gtgcatttct?ttg?ggc?gtg?ggt?act 115

Leu?Gly?Val?Gly?Thr

1 5

cct?cag?cag?aag?ggt?act?tat?gcg?gcg?gat?ctg?acg?tat?gtt?cgt?cag 163

Pro?Gln?Gln?Lys?Gly?Thr?Tyr?Ala?Ala?Asp?Leu?Thr?Tyr?Val?Arg?Gln

10 15 20

gtt?gtt?gag?gat?ttg?gtg?ccg?ctg?ctt?gag?ggc?gag?cac?att?att?ttc 211

Val?Val?Glu?Asp?Leu?Val?Pro?Leu?Leu?Glu?Gly?Glu?His?Ile?Ile?Phe

25 30 35

ggc?aag?tct?acg?gtt?ccg?gtt?ggt?act?gct?gag?cag?ttg?cag?gag?ctt 259

Gly?Lys?Ser?Thr?Val?Pro?Val?Gly?Thr?Ala?Glu?Gln?Leu?Gln?Glu?Leu

40 45 50

gct?gat?tct?ctg?gtc?aag?cct?ggt?tcg?cac?gtg?gag?atc?gcg?tgg?aat 307

Ala?Asp?Ser?Leu?Val?Lys?Pro?Gly?Ser?His?Val?Glu?Ile?Ala?Trp?Asn

55 60 65

ccg?gag?ttc?ttg?cgt?gag?ggc?tac?gcg?gtc?aaa?gac?acc?atc?act?ccg 355

Pro?Glu?Phe?Leu?Arg?Glu?Gly?Tyr?Ala?Val?Lys?Asp?Thr?Ile?Thr?Pro

70 75 80 85

gac?cgc?atc?gtg?gtg?ggt?gtg?cgt?gaa?taagaca 389

Asp?Arg?Ile?Val?Val?Gly?Val?Arg?Glu

90

<210>466

<211>94

<212>PRT

＜213〉Corynebacterium glutamicum

<400>466

Leu?Gly?Val?Gly?Thr?Pro?Gln?Gln?Lys?Gly?Thr?Tyr?Ala?Ala?Asp?Leu

1 5 10 15

Thr?Tyr?Val?Arg?Gln?Val?Val?Glu?Asp?Leu?Val?Pro?Leu?Leu?Glu?Gly

20 25 30

Glu?His?Ile?Ile?Phe?Gly?Lys?Ser?Thr?Val?Pro?Val?Gly?Thr?Ala?Glu

35 40 45

Gln?Leu?Gln?Glu?Leu?Ala?Asp?Ser?Leu?Val?Lys?Pro?Gly?Ser?His?Val

50 55 60

Glu?Ile?Ala?Trp?Asn?Pro?Glu?Phe?Leu?Arg?Glu?Gly?Tyr?Ala?Val?Lys

65 70 75 80

Asp?Thr?Ile?Thr?Pro?Asp?Arg?Ile?Val?Val?Gly?Val?Arg?Glu

85 90

<210>467

<211>801

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(778)

<223>RXN03056

<400>467

ttactatcac?tggttttgca?gatgagatcg?cacatgatct?cgacgaacag?atttccttac?60

ttaataaact?gaagaacagc?tcgcggaagc?taaagccaaa?ttg?gat?gcc?gca?gga 115

Leu?Asp?Ala?Ala?Gly

1 5

att?tca?ctt?tca?gcc?gtt?gga?tcc?gac?ttc?ggc?aag?atc?aac?atc?acc 163

Ile?Ser?Leu?Ser?Ala?Val?Gly?Ser?Asp?Phe?Gly?Lys?Ile?Asn?Ile?Thr

10 15 20

gat?cct?ttt?gaa?gat?cac?ttg?gag?cgc?gca?cgc?cac?ggt?gtt?gag?gtc 211

Asp?Pro?Phe?Glu?Asp?His?Leu?Glu?Arg?Ala?Arg?His?Gly?Val?Glu?Val

25 30 35

gct?aag?ctc?ttc?ggc?gcg?aaa?tac?atc?cgc?atg?ttc?tcc?ttc?ttt?att 259

Ala?Lys?Leu?Phe?Gly?Ala?Lys?Tyr?Ile?Arg?Met?Phe?Ser?Phe?Phe?Ile

40 45 50

gca?gaa?ggc?gac?aac?cct?gaa?agc?ttc?cgc?aaa?gaa?gta?ctc?tcc?cgc 307

Ala?Glu?Gly?Asp?Asn?Pro?Glu?Set?Phe?Arg?Lys?Glu?Val?Leu?Ser?Arg

55 60 65

acc?cac?gca?atg?gtc?gaa?ctc?gca?gaa?gcc?ggc?ggc?atc?acc?ctc?ctc 355

Thr?His?Ala?Met?Val?Glu?Leu?Ala?Glu?Ala?Gly?Gly?Ile?Thr?Leu?Leu

70 75 80 85

cac?gaa?aat?gaa?aag?gga?atc?tat?ggc?gac?tcc?ccg?cag?cgc?gtg?aag 403

His?Glu?Asn?Glu?Lys?Gly?Ile?Tyr?Gly?Asp?Ser?Pro?Gln?Arg?Val?Lys

90 95 100

gat?tta?atc?acc?agc?atc?gac?tcc?cct?aac?tac?cgc?gca?atc?tac?gac 451

Asp?Leu?Ile?Thr?Ser?Ile?Asp?Ser?Pro?Asn?Tyr?Arg?Ala?Ile?Tyr?Asp

105 110 115

gca?gct?aac?tac?gtg?caa?acc?gga?ttc?aag?cct?ttt?gat?gag?gca?tgg 499

Ala?Ala?Asn?Tyr?Val?Gln?Thr?Gly?Phe?Lys?Pro?Phe?Asp?Glu?Ala?Trp

120 125 130

ccg?atc?gtt?aag?gac?tac?gtc?gac?tac?gtc?cac?atc?aag?gac?gcg?acc 547

Pro?Ile?Val?Lys?Asp?Tyr?Val?Asp?Tyr?Val?His?Ile?Lys?Asp?Ala?Thr

135 140 145

att?cca?gat?gca?gag?cac?ccc?atc?gga?atc?atc?aag?cca?gca?gga?caa 595

Ile?Pro?Asp?Ala?Glu?His?Pro?Ile?Gly?Ile?Ile?Lys?Pro?Ala?Gly?Gln

150 155 160 165

ggc?gac?ggc?caa?tac?cca?gag?ctc?ctt?gcc?gcg?cta?aac?gcc?gac?ggt 643

Gly?Asp?Gly?Gln?Tyr?Pro?Glu?Leu?Leu?Ala?Ala?Leu?Asn?Ala?Asp?Gly

170 175 180

tac?aac?gga?ttc?gtc?tcc?atc?gag?cct?cac?ctg?ggt?gac?ttc?gat?gaa 691

Tyr?Asn?Gly?Phe?Val?Ser?Ile?Glu?Pro?His?Leu?Gly?Asp?Phe?Asp?Glu

185 190 195

ttc?ggc?gga?ctc?tgc?gga?cct?gac?ctg?tgg?acc?agc?gca?tgc?gac?gct 739

Phe?Gly?Gly?Leu?Cys?Gly?Pro?Asp?Leu?Trp?Thr?Ser?Ala?Cys?Asp?Ala

200 205 210

ctc?gca?gga?atc?ctg?aac?aac?atc?aac?gcc?gag?tac?aac?taaggacaac 788

Leu?Ala?Gly?Ile?Leu?Asn?Asn?Ile?Asn?Ala?Glu?Tyr?Asn

215 220 225

tgataatgac?aaa 801

<210>468

<211>226

<212>PRT

＜213〉Corynebacterium glutamicum

<400>468

Leu?Asp?Ala?Ala?Gly?Ile?Ser?Leu?Ser?Ala?Val?Gly?Ser?Asp?Phe?Gly

1 5 10 15

Lys?Ile?Asn?Ile?Thr?Asp?Pro?Phe?Glu?Asp?His?Leu?Glu?Arg?Ala?Arg

20 25 30

His?Gly?Val?Glu?Val?Ala?Lys?Leu?Phe?Gly?Ala?Lys?Tyr?Ile?Arg?Met

35 40 45

Phe?Ser?Phe?Phe?Ile?Ala?Glu?Gly?Asp?Asn?Pro?Glu?Ser?Phe?Arg?Lys

50 55 60

Glu?Val?Leu?Ser?Arg?Thr?His?Ala?Met?Val?Glu?Leu?Ala?Glu?Ala?Gly

65 70 75 80

Gly?Ile?Thr?Leu?Leu?His?Glu?Asn?Glu?Lys?Gly?Ile?Tyr?Gly?Asp?Ser

85 90 95

Pro?Gln?Arg?Val?Lys?Asp?Leu?Ile?Thr?Ser?Ile?Asp?Ser?Pro?Asn?Tyr

100 105 110

Arg?Ala?Ile?Tyr?Asp?Ala?Ala?Asn?Tyr?Val?Gln?Thr?Gly?Phe?Lys?Pro

115 120 125

Phe?Asp?Glu?Ala?Trp?Pro?Ile?Val?Lys?Asp?Tyr?Val?Asp?Tyr?Val?His

130 135 140

Ile?Lys?Asp?Ala?Thr?Ile?Pro?Asp?Ala?Glu?His?Pro?Ile?Gly?Ile?Ile

145 150 155 160

Lys?Pro?Ala?Gly?Gln?Gly?Asp?Gly?Gln?Tyr?Pro?Glu?Leu?Leu?Ala?Ala

165 170 175

Leu?Asn?Ala?Asp?Gly?Tyr?Asn?Gly?Phe?Val?Ser?Ile?Glu?Pro?His?Leu

180 185 190

Gly?Asp?Phe?Asp?Glu?Phe?Gly?Gly?Leu?Cys?Gly?Pro?Asp?Leu?Trp?Thr

195 200 205

Ser?Ala?Cys?Asp?Ala?Leu?Ala?Gly?Ile?Leu?Asn?Asn?Ile?Asn?Ala?Glu

210 215 220

Tyr?Asn

225

<210>469

<211>687

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(664)

<223>RXN03030

<400>469

gaagatgaag?cagaaaagat?cattggtgcg?ccagaggttt?ctgcattggg?caacaaagca?60

cagcttgatt?ccgtcacctt?gctgcgtaac?aaccccatcc?gtg?ctg?cca?ctg?gat 115

Val?Leu?Pro?Leu?Asp

1 5

cct?gca?gca?agc?ctg?aag?atc?tac?cca?ttg?gtt?act?ggc?cgt?acc?aag 163

Pro?Ala?Ala?Ser?Leu?Lys?Ile?Tyr?Pro?Leu?Val?Thr?Gly?Arg?Thr?Lys

10 15 20

atc?gac?gag?gtt?caa?cta?cag?ctg?gaa?gca?gcc?att?cgc?gca?gaa?ctc 211

Ile?Asp?Glu?Val?Gln?Leu?Gln?Leu?Glu?Ala?Ala?Ile?Arg?Ala?Glu?Leu

25 30 35

cca?ggg?gta?acc?ttg?gtg?tct?tcc?gag?tca?gaa?gca?gat?ctt?gca?atc 259

Pro?Gly?Val?Thr?Leu?Val?Ser?Ser?Glu?Ser?Glu?Ala?Asp?Leu?Ala?Ile

40 45 50

gtg?tgg?gct?cgc?cct?gaa?att?gca?ctg?ttt?gaa?gat?gac?ctc?gaa?ggt 307

Val?Trp?Ala?Arg?Pro?Glu?Ile?Ala?Leu?Phe?Glu?Asp?Asp?Leu?Glu?Gly

55 60 65

gtt?tcc?ctc?tct?gtt?gac?cct?cgt?gcc?aat?ggt?gtc?gat?gtg?gaa?cgc 355

Val?Ser?Leu?Ser?Val?Asp?Pro?Arg?Ala?Asn?Gly?Val?Asp?Val?Glu?Arg

70 75 80 85

gtt?cag?gct?gtg?gaa?gct?gca?gtc?cca?acc?atc?ttg?gct?gtg?aac?ttc 403

Val?Gln?Ala?Val?Glu?Ala?Ala?Val?Pro?Thr?Ile?Leu?Ala?Val?Asn?Phe

90 95 100

acc?aac?cct?tgg?gtg?ctg?tct?gag?atc?gag?cct?ggt?gcc?gct?gcc?gtg 451

Thr?Asn?Pro?Trp?Val?Leu?Ser?Glu?Ile?Glu?Pro?Gly?Ala?Ala?Ala?Val

105 110 115

gtg?ggc?act?ttt?gag?atc?aag?cca?gag?ttc?ctt?ctc?aag?gct?ttg?act 499

Val?Gly?Thr?Phe?Glu?Ile?Lys?Pro?Glu?Phe?Leu?Leu?Lys?Ala?Leu?Thr

120 125 130

ggt?caa?gag?gga?gga?cca?aag?ggc?aag?ctg?cca?ttg?act?gtt?cct?gct 547

Gly?Gln?Glu?Gly?Gly?Pro?Lys?Gly?Lys?Leu?Pro?Leu?Thr?Val?Pro?Ala

135 140 145

tcc?atg?cag?gcg?att?gct?gat?tcc?cct?cgc?gat?atc?cca?ggc?aag?ttc 595

Ser?Met?Gln?Ala?Ile?Ala?Asp?Ser?Pro?Arg?Asp?Ile?Pro?Gly?Lys?Phe

150 155 160 165

ctc?gat?gag?tct?tac?acc?tac?gtg?gac?tcc?gca?ggg?atg?gcc?tac?aag 643

Leu?Asp?Glu?Ser?Tyr?Thr?Tyr?Val?Asp?Ser?Ala?Gly?Met?Ala?Tyr?Lys

170 175 180

tac?ggt?cac?gga?ctt?aat?ttc?tagattgtag?gtagtctcgt?ggg 687

Tyr?Gly?His?Gly?Leu?Asn?Phe

185

<210>470

<211>188

<212>PRT

＜213〉Corynebacterium glutamicum

<400>470

Val?Leu?Pro?Leu?Asp?Pro?Ala?Ala?Ser?Leu?Lys?Ile?Tyr?Pro?Leu?Val

1 5 10 15

Thr?Gly?Arg?Thr?Lys?Ile?Asp?Glu?Val?Gln?Leu?Gln?Leu?Glu?Ala?Ala

20 25 30

Ile?Arg?Ala?Glu?Leu?Pro?Gly?Val?Thr?Leu?Val?Ser?Ser?Glu?Ser?Glu

35 40 45

Ala?Asp?Leu?Ala?Ile?Val?Trp?Ala?Arg?Pro?Glu?Ile?Ala?Leu?Phe?Glu

50 55 60

Asp?Asp?Leu?Glu?Gly?Val?Ser?Leu?Ser?Val?Asp?Pro?Arg?Ala?Asn?Gly

65 70 75 80

Val?Asp?Val?Glu?Arg?Val?Gln?Ala?Val?Glu?Ala?Ala?Val?Pro?Thr?Ile

85 90 95

Leu?Ala?Val?Asn?Phe?Thr?Asn?Pro?Trp?Val?Leu?Ser?Glu?Ile?Glu?Pro

100 105 110

Gly?Ala?Ala?Ala?Val?Val?Gly?Thr?Phe?Glu?Ile?Lys?Pro?Glu?Phe?Leu

115 120 125

Leu?Lys?Ala?Leu?Thr?Gly?Gln?Glu?Gly?Gly?Pro?Lys?Gly?Lys?Leu?Pro

130 135 140

Leu?Thr?Val?Pro?Ala?Ser?Met?Gln?Ala?Ile?Ala?Asp?Ser?Pro?Arg?Asp

145 150 155 160

Ile?Pro?Gly?Lys?Phe?Leu?Asp?Glu?Ser?Tyr?Thr?Tyr?Val?Asp?Ser?Ala

165 170 175

Gly?Met?Ala?Tyr?Lys?Tyr?Gly?His?Gly?Leu?Asn?Phe

180 185

<210>471

<211>1062

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1039)

<223>RXN00401

<400>471

cttttaagca?tttcaacatg?ccaaactaat?cttggacagg?tatcactggc?tcctcttaga?60

ctccaaagtg?tcttagaaaa?cactcaccca?aggagccctc?atg?gca?cgc?ttt?tca 115

Met?Ala?Arg?Phe?Ser

1 5

cca?caa?gat?ctc?gca?gac?cac?ctc?aag?gat?gga?ctg?ctc?tct?ttc?ccg 163

Pro?Gln?Asp?Leu?Ala?Asp?His?Leu?Lys?Asp?Gly?Leu?Leu?Ser?Phe?Pro

10 15 20

gcc?acc?gct?ttc?caa?gat?gac?ctc?gaa?gta?gat?gaa?gct?gct?tat?gtc 211

Ala?Thr?Ala?Phe?Gln?Asp?Asp?Leu?Glu?Val?Asp?Glu?Ala?Ala?Tyr?Val

25 30 35

gag?cac?att?gaa?tgg?cag?tcc?agc?tac?cca?gtc?gcc?ggc?ctc?ttc?gca 259

Glu?His?Ile?Glu?Trp?Gln?Ser?Ser?Tyr?Pro?Val?Ala?Gly?Leu?Phe?Ala

40 45 50

gct?ggc?ggt?act?ggc?gaa?gga?ttc?agc?ctt?acc?gtt?gag?gaa?aac?cac 307

Ala?Gly?Gly?Thr?Gly?Glu?Gly?Phe?Ser?Leu?Thr?Val?Glu?Glu?Asn?His

55 60 65

cgt?gtc?act?caa?ctt?gca?gtt?cag?gcg?tcc?agc?ccg?gaa?gtt?ccc?gtg 355

Arg?Val?Thr?Gln?Leu?Ala?Val?Gln?Ala?Ser?Ser?Pro?Glu?Val?Pro?Val

70 75 80 85

ttg?ggg?tct?gct?act?ggc?tca?act?aag?tct?gcc?atc?gca?aac?gca?cag 403

Leu?Gly?Ser?Ala?Thr?Gly?Ser?Thr?Lys?Ser?Ala?Ile?Ala?Asn?Ala?Gln

90 95 100

ggc?gca?gag?gca?gca?ggc?gct?gaa?ggt?gtc?ctc?ctg?ctt?cct?ccc?tac 451

Gly?Ala?Glu?Ala?Ala?Gly?Ala?Glu?Gly?Val?Leu?Leu?Leu?Pro?Pro?Tyr

105 110 115

ctc?acc?gaa?tgc?gac?gca?gaa?ggc?ctg?tac?aac?cat?gca?gcc?gca?gtc 499

Leu?Thr?Glu?Cys?Asp?Ala?Glu?Gly?Leu?Tyr?Asn?His?Ala?Ala?Ala?Val

120 125 130

tgt?gaa?tcc?act?tct?ctt?ggt?gtc?atc?gtg?tac?aac?cgt?gcc?aat?gcc 547

Cys?Glu?Ser?Thr?Ser?Leu?Gly?Val?Ile?Val?Tyr?Asn?Arg?Ala?Asn?Ala

135 140 145

atc?tac?tcc?cca?gag?gtt?atc?gct?cga?ctc?tct?gag?cgc?tac?ccc?aac 595

Ile?Tyr?Ser?Pro?Glu?Val?Ile?Ala?Arg?Leu?Ser?Glu?Arg?Tyr?Pro?Asn

150 155 160 165

ttc?att?gga?ttt?aaa?gat?ggc?acc?gga?aac?atc?gag?cac?cta?gca?aag 643

Phe?Ile?Gly?Phe?Lys?Asp?Gly?Thr?Gly?Asn?Ile?Glu?His?Leu?Ala?Lys

170 175 180

atc?acc?acg?cta?tgc?gga?gat?cgc?ctg?ttc?tac?ctc?ggt?gga?ctt?ccc 691

Ile?Thr?Thr?Leu?Cys?Gly?Asp?Arg?Leu?Phe?Tyr?Leu?Gly?Gly?Leu?Pro

185 190 195

acc?gct?gag?acc?ttt?gca?cta?cca?ctg?ctt?cag?atg?ggc?atg?agc?acc 739

Thr?Ala?Glu?Thr?Phe?Ala?Leu?Pro?Leu?Leu?Gln?Met?Gly?Met?Ser?Thr

200 205 210

tac?tcc?tct?gca?atg?ttc?aac?ttc?att?cca?gat?ttc?gca?ctg?agc?ttc 787

Tyr?Ser?Ser?Ala?Met?Phe?Asn?Phe?Ile?Pro?Asp?Phe?Ala?Leu?Ser?Phe

215 220 225

tac?gcc?gat?gtt?cgt?gcg?cag?gac?agc?gca?gca?gta?aag?cag?aag?ctg 835

Tyr?Ala?Asp?Val?Arg?Ala?Gln?Asp?Ser?Ala?Ala?Val?Lys?Gln?Lys?Leu

230 235 240 245

agc?gat?ttt?gtg?ctc?ccc?tac?ttg?gat?atc?cgc?gat?cgc?gca?caa?ggc 883

Ser?Asp?Phe?Val?Leu?Pro?Tyr?Leu?Asp?Ile?Arg?Asp?Arg?Ala?Gln?Gly

250 255 260

tac?ggt?gtc?tcc?att?ggt?aag?ggc?gga?ctc?aag?gct?gtt?ggc?cgc?aac 931

Tyr?Gly?Val?Ser?Ile?Gly?Lys?Gly?Gly?Leu?Lys?Ala?Val?Gly?Arg?Asn

265 270 275

gct?ggc?ggc?gtt?cgc?cca?cca?ctg?cgt?aac?ctt?tcc?gag?caa?gat?atc 979

Ala?Gly?Gly?Val?Arg?Pro?Pro?Leu?Arg?Asn?Leu?Ser?Glu?Gln?Asp?Ile

280 285 290

gcg?gac?ctg?tcg?gat?ttg?ctt?gcc?acc?tct?ggc?gca?ggt?tcc?tac?cgc 1027

Ala?Asp?Leu?Ser?Asp?Leu?Leu?Ala?Thr?Ser?Gly?Ala?Gly?Ser?Tyr?Arg

295 300 305

ctt?cag?ttg?agg?tgaaagcatg?atcaccgcaa?ccg 1062

Leu?Gln?Leu?Arg

310

<210>472

<211>313

<212>PRT

＜213〉Corynebacterium glutamicum

<400>472

Met?Ala?Arg?Phe?Ser?Pro?Gln?Asp?Leu?Ala?Asp?His?Leu?Lys?Asp?Gly

1 5 10 15

Leu?Leu?Ser?Phe?Pro?Ala?Thr?Ala?Phe?Gln?Asp?Asp?Leu?Glu?Val?Asp

20 25 30

Glu?Ala?Ala?Tyr?Val?Glu?His?Ile?Glu?Trp?Gln?Ser?Ser?Tyr?Pro?Val

35 40 45

Ala?Gly?Leu?Phe?Ala?Ala?Gly?Gly?Thr?Gly?Glu?Gly?Phe?Ser?Leu?Thr

50 55 60

Val?Glu?Glu?Asn?His?Arg?Val?Thr?Gln?Leu?Ala?Val?Gln?Ala?Ser?Ser

65 70 75 80

Pro?Glu?Val?Pro?Val?Leu?Gly?Ser?Ala?Thr?Gly?Ser?Thr?Lys?Ser?Ala

85 90 95

Ile?Ala?Asn?Ala?Gln?Gly?Ala?Glu?Ala?Ala?Gly?Ala?Glu?Gly?Val?Leu

100 105 110

Leu?Leu?Pro?Pro?Tyr?Leu?Thr?Glu?Cys?Asp?Ala?Glu?Gly?Leu?Tyr?Asn

115 120 125

His?Ala?Ala?Ala?Val?Cys?Glu?Ser?Thr?Ser?Leu?Gly?Val?Ile?Val?Tyr

130 135 140

Asn?Arg?Ala?Asn?Ala?Ile?Tyr?Ser?Pro?Glu?Val?Ile?Ala?Arg?Leu?Ser

145 150 155 160

Glu?Arg?Tyr?Pro?Asn?Phe?Ile?Gly?Phe?Lys?Asp?Gly?Thr?Gly?Asn?Ile

165 170 175

Glu?His?Leu?Ala?Lys?Ile?Thr?Thr?Leu?Cys?Gly?Asp?Arg?Leu?Phe?Tyr

180 185 190

Leu?Gly?Gly?Leu?Pro?Thr?Ala?Glu?Thr?Phe?Ala?Leu?Pro?Leu?Leu?Gln

195 200 205

Met?Gly?Met?Ser?Thr?Tyr?Ser?Ser?Ala?Met?Phe?Asn?Phe?Ile?Pro?Asp

210 215 220

Phe?Ala?Leu?Ser?Phe?Tyr?Ala?Asp?Val?Arg?Ala?Gln?Asp?Ser?Ala?Ala

225 230 235 240

Val?Lys?Gln?Lys?Leu?Ser?Asp?Phe?Val?Leu?Pro?Tyr?Leu?Asp?Ile?Arg

245 250 255

Asp?Arg?Ala?Gln?Gly?Tyr?Gly?Val?Ser?Ile?Gly?Lys?Gly?Gly?Leu?Lys

260 265 270

Ala?Val?Gly?Arg?Asn?Ala?Gly?Gly?Val?Arg?Pro?Pro?Leu?Arg?Asn?Leu

275 280 285

Ser?Glu?Gln?Asp?Ile?Ala?Asp?Leu?Ser?Asp?Leu?Leu?Ala?Thr?Ser?Gly

290 295 300

Ala?Gly?Ser?Tyr?Arg?Leu?Gln?Leu?Arg

305 310

<210>473

<211>924

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(901)

<223>RXN02125

<400>473

gacctaaaat?tcatcacctc?accgttttta?aggcttagaa?aaatagcagt?gttgggatgt?60

gaatatccat?ttatgctgct?gtagtcggct?atgtggacgc?atg?gtg?gca?acc?tct 115

Met?Val?Ala?Thr?Ser

1 5

cag?ttt?atc?gat?gac?agc?gag?gct?gcc?cag?gcg?gta?cgc?gca?gct?att 163

Gln?Phe?Ile?Asp?Asp?Ser?Glu?Ala?Ala?Gln?Ala?Val?Arg?Ala?Ala?Ile

10 15 20

gtt?gca?gga?tac?cga?aac?att?gat?act?gcc?cta?gcg?tat?gga?aac?gag 211

Val?Ala?Gly?Tyr?Arg?Asn?Ile?Asp?Thr?Ala?Leu?Ala?Tyr?Gly?Asn?Glu

25 30 35

cgc?ggc?gtt?ggc?gaa?ggc?att?cgc?acc?gct?gga?gtg?ccc?cgc?gag?gag 259

Arg?Gly?Val?Gly?Glu?Gly?Ile?Arg?Thr?Ala?Gly?Val?Pro?Arg?Glu?Glu

40 45 50

ctc?ttt?att?tcc?acc?aag?cta?gct?gca?gaa?atc?aaa?gat?tac?gat?gga 307

Leu?Phe?Ile?Ser?Thr?Lys?Leu?Ala?Ala?Glu?Ile?Lys?Asp?Tyr?Asp?Gly

55 60 65

gca?gtc?gcc?gcg?att?gat?gag?tct?ttg?gcg?aaa?att?ggc?ttg?gat?tat 355

Ala?Val?Ala?Ala?Ile?Asp?Glu?Ser?Leu?Ala?Lys?Ile?Gly?Leu?Asp?Tyr

70 75 80 85

gtc?gat?ctg?atg?ctc?att?cac?tcc?cca?caa?cca?tgg?agt?gat?ttc?cgt 403

Val?Asp?Leu?Met?Leu?Ile?His?Ser?Pro?Gln?Pro?Trp?Ser?Asp?Phe?Arg

90 95 100

ggt?ggg?gac?tat?tca?gag?gga?aac?cgt?gaa?gcg?tgg?cgc?gcg?ctg?gaa 451

Gly?Gly?Asp?Tyr?Ser?Glu?Gly?Asn?Arg?Glu?Ala?Trp?Arg?Ala?Leu?Glu

105 110 115

gat?gcc?tac?aaa?gcc?gga?aag?att?cga?tcc?att?ggt?gtc?tcg?aac?ttc 499

Asp?Ala?Tyr?Lys?Ala?Gly?Lys?Ile?Arg?Ser?Ile?Gly?Val?Ser?Asn?Phe

120 125 130

ctg?gag?gcc?gat?ctg?gag?aat?atc?tta?gac?tcc?gcg?acg?gtt?gct?cct 547

Leu?Glu?Ala?Asp?Leu?Glu?Asn?Ile?Leu?Asp?Ser?Ala?Thr?Val?Ala?Pro

135 140 145

cac?gtt?aat?cag?ctt?ctt?gtg?cat?gtt?gga?aac?acc?cca?agc?gag?tta 595

His?Val?Asn?Gln?Leu?Leu?Val?His?Val?Gly?Asn?Thr?Pro?Ser?Glu?Leu

150 155 160 165

atc?agt?ttc?tgc?gat?tcc?aag?ggc?att?ctg?gtc?gaa?gca?tat?tca?ccc 643

Ile?Ser?Phe?Cys?Asp?Ser?Lys?Gly?Ile?Leu?Val?Glu?Ala?Tyr?Ser?Pro

170 175 180

atc?gcc?cac?gga?gag?atg?ctg?aag?aac?cag?cag?gtc?aag?gcg?att?gct 691

Ile?Ala?His?Gly?Glu?Met?Leu?Lys?Asn?Gln?Gln?Val?Lys?Ala?Ile?Ala

185 190 195

gac?aag?tac?aac?gtg?agc?att?ccg?cag?cta?tgc?att?cgg?tac?aca?att 739

Asp?Lys?Tyr?Asn?Val?Ser?Ile?Pro?Gln?Leu?Cys?Ile?Arg?Tyr?Thr?Ile

200 205 210

caa?ctg?gga?acg?gtg?tct?ttg?cca?aag?act?gcc?aac?cca?gat?cat?atg 787

Gln?Leu?Gly?Thr?Val?Ser?Leu?Pro?Lys?Thr?Ala?Asn?Pro?Asp?His?Met

215 220 225

agc?tcc?aat?gcg?cag?atc?gac?ttt?gaa?att?tcc?gag?gaa?gac?atg?gcg 835

Ser?Ser?Asn?Ala?Gln?Ile?Asp?Phe?Glu?Ile?Ser?Glu?Glu?Asp?Met?Ala

230 235 240 245

gca?ctt?caa?gaa?gtg?acc?gcc?cgc?gat?tat?ggc?gag?cac?agc?ggt?ttt 883

Ala?Leu?Gln?Glu?Val?Thr?Ala?Arg?Asp?Tyr?Gly?Glu?His?Ser?Gly?Phe

250 255 260

cct?gtg?tat?tcc?ggc?aag?tagaaagatt?tttatcatgg?gac 924

Pro?Val?Tyr?Ser?Gly?Lys

265

<210>474

<211>267

<212>PRT

＜213〉Corynebacterium glutamicum

<400>474

Met?Val?Ala?Thr?Ser?Gln?Phe?Ile?Asp?Asp?Ser?Glu?Ala?Ala?Gln?Ala

1 5 10 15

Val?Arg?Ala?Ala?Ile?Val?Ala?Gly?Tyr?Arg?Asn?Ile?Asp?Thr?Ala?Leu

20 25 30

Ala?Tyr?Gly?Asn?Glu?Arg?Gly?Val?Gly?Glu?Gly?Ile?Arg?Thr?Ala?Gly

35 40 45

Val?Pro?Arg?Glu?Glu?Leu?Phe?Ile?Ser?Thr?Lys?Leu?Ala?Ala?Glu?Ile

50 55 60

Lys?Asp?Tyr?Asp?Gly?Ala?Val?Ala?Ala?Ile?Asp?Glu?Ser?Leu?Ala?Lys

65 70 75 80

Ile?Gly?Leu?Asp?Tyr?Val?Asp?Leu?Met?Leu?Ile?His?Ser?Pro?Gln?Pro

85 90 95

Trp?Ser?Asp?Phe?Arg?Gly?Gly?Asp?Tyr?Ser?Glu?Gly?Asn?Arg?Glu?Ala

100 105 110

Trp?Arg?Ala?Leu?Glu?Asp?Ala?Tyr?Lys?Ala?Gly?Lys?Ile?Arg?Ser?Ile

115 120 125

Gly?Val?Ser?Asn?Phe?Leu?Glu?Ala?Asp?Leu?Glu?Asn?Ile?Leu?Asp?Ser

130 135 140

Ala?Thr?Val?Ala?Pro?His?Val?Asn?Gln?Leu?Leu?Val?His?Val?Gly?Asn

145 150 155 160

Thr?Pro?Ser?Glu?Leu?Ile?Ser?Phe?Cys?Asp?Ser?Lys?Gly?Ile?Leu?Val

165 170 175

Glu?Ala?Tyr?Ser?Pro?Ile?Ala?His?Gly?Glu?Met?Leu?Lys?Asn?Gln?Gln

180 185 190

Val?Lys?Ala?Ile?Ala?Asp?Lys?Tyr?Asn?Val?Ser?Ile?Pro?Gln?Leu?Cys

195 200 205

Ile?Arg?Tyr?Thr?Ile?Gln?Leu?Gly?Thr?Val?Ser?Leu?Pro?Lys?Thr?Ala

210 215 220

Asn?Pro?Asp?His?Met?Ser?Ser?Asn?Ala?Gln?Ile?Asp?Phe?Glu?Ile?Ser

225 230 235 240

Glu?Glu?Asp?Met?Ala?Ala?Leu?Gln?Glu?Val?Thr?Ala?Arg?Asp?Tyr?Gly

245 250 255

Glu?His?Ser?Gly?Phe?Pro?Val?Tyr?Ser?Gly?Lys

260 265

<210>475

<211>3561

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(3538)

<223>RXN00200

<400>475

aacccggagt?catttgatca?gatgtggcag?accaagcaag?tgggaccttt?cgtggtggta?60

acgcacaatg?agtaattcct?caccaaacga?cccaagccct?atg?cgc?caa?gtc?ggt 115

Met?Arg?Gln?Val?Gly

1 5

ggt?aat?ggg?ggc?cat?caa?cta?gac?tcg?atc?aac?gtg?tca?gat?gta?gtt 163

Gly?Asn?Gly?Gly?His?Gln?Leu?Asp?Ser?Ile?Asn?Val?Ser?Asp?Val?Val

10 15 20

gag?tcg?aag?aaa?cta?aag?ggt?tct?gcg?caa?gaa?ccc?ccg?cag?gtt?gcc 211

Glu?Ser?Lys?Lys?Leu?Lys?Gly?Ser?Ala?Gln?Glu?Pro?Pro?Gln?Val?Ala

25 30 35

ccg?ggc?tgg?ctg?aag?aaa?ctg?gct?atc?tca?tca?ggt?ctg?ctt?ggc?ctg 259

Pro?Gly?Trp?Leu?Lys?Lys?Leu?Ala?Ile?Ser?Ser?Gly?Leu?Leu?Gly?Leu

40 45 50

ttg?atg?ttt?gtg?ctg?ttg?cct?ttc?ctg?cca?gtg?aac?cag?gtg?cag?tct 307

Leu?Met?Phe?Val?Leu?Leu?Pro?Phe?Leu?Pro?Val?Asn?Gln?Val?Gln?Ser

55 60 65

tcg?ctg?tca?tgg?cca?caa?aat?ggt?gag?ctt?tcc?agc?gtt?aac?gcc?ccg 355

Ser?Leu?Ser?Trp?Pro?Gln?Asn?Gly?Glu?Leu?Ser?Ser?Val?Asn?Ala?Pro

70 75 80 85

ctg?att?tcc?tac?gca?ccg?cag?tcg?atg?gat?gcg?tcc?atc?cct?gtg?tcc 403

Leu?Ile?Ser?Tyr?Ala?Pro?Gln?Ser?Met?Asp?Ala?Ser?Ile?Pro?Val?Ser

90 95 100

gcg?ctg?gac?agt?ctc?aat?gac?aat?cag?tcg?ttg?gtg?atg?ggc?acg?ttg 451

Ala?Leu?Asp?Ser?Leu?Asn?Asp?Asn?Gln?Ser?Leu?Val?Met?Gly?Thr?Leu

105 110 115

cct?ctg?gac?agt?acg?gac?gcc?acc?aac?cgt?ggt?ctg?ttt?gtg?cgc?acc 499

Pro?Leu?Asp?Ser?Thr?Asp?Ala?Thr?Asn?Arg?Gly?Leu?Phe?Val?Arg?Thr

120 125 130

atc?gac?ggt?aac?ctt?gac?gtg?att?gtt?cgc?ggt?gag?gtg?ctg?ttg?gat 547

Ile?Asp?Gly?Asn?Leu?Asp?Val?Ile?Val?Arg?Gly?Glu?Val?Leu?Leu?Asp

135 140 145

ctt?tca?cca?aca?gag?gtg?aac?cgt?ctg?cca?gat?gat?gcg?atc?cta?gag 595

Leu?Ser?Pro?Thr?Glu?Val?Asn?Arg?Leu?Pro?Asp?Asp?Ala?Ile?Leu?Glu

150 155 160 165

att?tcc?tcc?acc?gag?gaa?acc?acc?agc?gcg?gaa?atc?acc?ggc?acg?gca 643

Ile?Ser?Ser?Thr?Glu?Glu?Thr?Thr?Ser?Ala?Glu?Ile?Thr?Gly?Thr?Ala

170 175 180

ttc?agc?ggc?gag?acc?gaa?ggc?gat?gag?cgg?cct?cag?gtc?acc?ggc?gtt 691

Phe?Ser?Gly?Glu?Thr?Glu?Gly?Asp?Glu?Arg?Pro?Gln?Val?Thr?Gly?Val

185 190 195

tac?acc?gag?ctt?gtc?gac?gac?ccc?tcc?acc?gca?tcg?gcc?ctg?gcc?tca 739

Tyr?Thr?Glu?Leu?Val?Asp?Asp?Pro?Ser?Thr?Ala?Ser?Ala?Leu?Ala?Ser

200 205 210

gcg?ggc?tta?aac?gtt?gat?att?gag?atc?aac?tcc?cgc?ttc?act?tca?tcc 787

Ala?Gly?Leu?Asn?Val?Asp?Ile?Glu?Ile?Asn?Ser?Arg?Phe?Thr?Ser?Ser

215 220 225

ccc?agc?ctt?cta?aag?tac?gca?gcc?atc?ttc?att?ggc?ctt?gcg?tct?gtg 835

Pro?Ser?Leu?Leu?Lys?Tyr?Ala?Ala?Ile?Phe?Ile?Gly?Leu?Ala?Ser?Val

230 235 240 245

ttg?gtc?tcc?ctg?tgg?aca?ctg?cac?cgc?atg?gat?att?ttg?gat?ggt?cga 883

Leu?Val?Ser?Leu?Trp?Thr?Leu?His?Arg?Met?Asp?Ile?Leu?Asp?Gly?Arg

250 255 260

aaa?gca?cac?cgc?ttc?ctg?cct?gcc?aac?tgg?tac?aag?ctg?aag?cca?ctt 931

Lys?Ala?His?Arg?Phe?Leu?Pro?Ala?Asn?Trp?Tyr?Lys?Leu?Lys?Pro?Leu

265 270 275

gat?ggt?gtt?gtc?gta?gcg?att?ttg?gtg?ttc?tgg?cac?ttc?ctt?ggc?gcc 979

Asp?Gly?Val?Val?Val?Ala?Ile?Leu?Val?Phe?Trp?His?Phe?Leu?Gly?Ala

280 285 290

aac?acc?tct?gac?gac?ggc?ttc?atc?atg?acc?atg?gcc?cgc?gtg?tcc?cag 1027

Asn?Thr?Ser?Asp?Asp?Gly?Phe?Ile?Met?Thr?Met?Ala?Arg?Val?Ser?Gln

295 300 305

aac?gcg?gat?tat?atg?gcc?aac?tac?tac?cgc?tgg?ttc?ggt?gtc?cca?gaa 1075

Asn?Ala?Asp?Tyr?Met?Ala?Asn?Tyr?Tyr?Arg?Trp?Phe?Gly?Val?Pro?Glu

310 315 320 325

tca?cca?ttc?ggc?gca?cca?tat?tac?gac?ttg?ctg?gct?ctg?atg?gcc?tac 1123

Ser?Pro?Phe?Gly?Ala?Pro?Tyr?Tyr?Asp?Leu?Leu?Ala?Leu?Met?Ala?Tyr

330 335 340

atc?tca?acc?tca?tca?atc?tgg?ctt?cgt?cta?ccc?gca?ttg?ctc?gct?gga 1171

Ile?Ser?Thr?Ser?Ser?Ile?Trp?Leu?Arg?Leu?Pro?Ala?Leu?Leu?Ala?Gly

345 350 355

ctg?atc?atg?tgg?ttc?gtg?atc?acc?aga?gag?gtc?atg?cca?cgg?ttt?ggc 1219

Leu?Ile?Met?Trp?Phe?Val?Ile?Thr?Arg?Glu?Val?Met?Pro?Arg?Phe?Gly

360 365 370

tca?ttg?gtt?aac?ggt?cgc?cgc?gtt?gcg?cac?tgg?tct?gca?gcc?atg?gtg 1267

Ser?Leu?Val?Asn?Gly?Arg?Arg?Val?Ala?His?Trp?Ser?Ala?Ala?Met?Val

375 380 385

ttc?ctg?gcg?ttc?tgg?ctt?cca?tac?aac?aac?ggc?act?cgc?cca?gag?cca 1315

Phe?Leu?Ala?Phe?Trp?Leu?Pro?Tyr?Asn?Asn?Gly?Thr?Arg?Pro?Glu?Pro

390 395 400 405

atc?atc?gcg?atg?gga?gct?cta?ctt?gcg?tgg?gtt?tcc?ttc?gag?cgc?gct 1363

Ile?Ile?Ala?Met?Gly?Ala?Leu?Leu?Ala?Trp?Val?Ser?Phe?Glu?Arg?Ala

410 415 420

atc?gct?acc?tcc?agg?ttg?ttg?ccc?gct?gcc?att?ggt?gtc?att?atc?gcc 1411

Ile?Ala?Thr?Ser?Arg?Leu?Leu?Pro?Ala?Ala?Ile?Gly?Val?Ile?Ile?Ala

425 430 435

acc?att?tcc?ctg?gca?tca?ggc?ccc?acc?ggt?cta?atg?gca?gtt?gct?gcg 1459

Thr?Ile?Ser?Leu?Ala?Ser?Gly?Pro?Thr?Gly?Leu?Met?Ala?Val?Ala?Ala

440 445 450

ttg?ctg?gtc?agt?ttg?tcc?gcg?ttg?att?cgc?att?ctt?tat?agg?cgc?ttg 1507

Leu?Leu?Val?Ser?Leu?Ser?Ala?Leu?Ile?Arg?Ile?Leu?Tyr?Arg?Arg?Leu

455 460 465

ccg?ctt?att?ggg?gcg?tcg?agg?ggg?gcg?tcg?aaa?agc?aaa?gtc?ttt?ggc 1555

Pro?Leu?Ile?Gly?Ala?Ser?Arg?Gly?Ala?Ser?Lys?Ser?Lys?Val?Phe?Gly

470 475 480 485

gct?tcg?atg?gct?atg?ctt?gcc?cca?ttc?ctt?gcg?tct?ggc?acc?gcg?att 1603

Ala?Ser?Met?Ala?Met?Leu?Ala?Pro?Phe?Leu?Ala?Ser?Gly?Thr?Ala?Ile

490 495 500

ctc?atc?gcc?gtt?ttt?ggc?gat?cag?act?ctg?tca?acc?gtc?atg?gaa?tcc 1651

Leu?Ile?Ala?Val?Phe?Gly?Asp?Gln?Thr?Leu?Ser?Thr?Val?Met?Glu?Ser

505 510 515

atc?agc?gtg?cgc?tcc?gcg?aag?ggc?ccg?gca?ctg?acc?tgg?tac?cac?gaa 1699

Ile?Ser?Val?Arg?Ser?Ala?Lys?Gly?Pro?Ala?Leu?Thr?Trp?Tyr?His?Glu

520 525 530

tat?gtg?cgc?tac?caa?acc?gtc?atg?gaa?caa?acc?gtt?gat?ggt?tcc?ttc 1747

Tyr?Val?Arg?Tyr?Gln?Thr?Val?Met?Glu?Gln?Thr?Val?Asp?Gly?Ser?Phe

535 540 545

acc?cgc?cgt?ttt?gct?gtg?ctg?atg?ctc?atg?gcg?tgt?ctg?gct?att?gtg 1795

Thr?Arg?Arg?Phe?Ala?Val?Leu?Met?Leu?Met?Ala?Cys?Leu?Ala?Ile?Val

550 555 560 565

gtc?atc?gcg?atc?ctg?cgt?tac?ggc?cgc?att?cca?ggc?gct?gcg?aag?gga 1843

Val?Ile?Ala?Ile?Leu?Arg?Tyr?Gly?Arg?Ile?Pro?Gly?Ala?Ala?Lys?Gly

570 575 580

cca?tca?ctg?cgt?ttg?atg?atg?gtc?att?ttc?ggc?acc?atg?ttc?ttc?atg 1891

Pro?Ser?Leu?Arg?Leu?Met?Met?Val?Ile?Phe?Gly?Thr?Met?Phe?Phe?Met

585 590 595

atg?ttc?acc?cca?acc?aag?tgg?act?cac?cac?ttc?ggt?gtc?tac?gca?gga 1939

Met?Phe?Thr?Pro?Thr?Lys?Trp?Thr?His?His?Phe?Gly?Val?Tyr?Ala?Gly

600 605 610

ctt?gcc?ggc?gca?ttg?gcc?gga?ctt?gct?gcc?gtg?ggg?ctg?tcc?tat?gtt 1987

Leu?Ala?Gly?Ala?Leu?Ala?Gly?Leu?Ala?Ala?Val?Gly?Leu?Ser?Tyr?Val

615 620 625

gcg?gtg?aaa?tca?cca?cgc?atg?cgc?acc?att?tcc?atc?ggt?gcg?ttc?ctc 2035

Ala?Val?Lys?Ser?Pro?Arg?Met?Arg?Thr?Ile?Ser?Ile?Gly?Ala?Phe?Leu

630 635 640 645

ttc?ctg?ctg?gcg?ctg?gct?ctc?gca?ggc?gtg?aac?gga?ttc?tgg?tac?acc 2083

Phe?Leu?Leu?Ala?Leu?Ala?Leu?Ala?Gly?Val?Asn?Gly?Phe?Trp?Tyr?Thr

650 655 660

tcc?agc?tac?gcc?gtg?cca?tgg?tgg?gat?aaa?acc?atc?cag?atc?aag?ggc 2131

Ser?Ser?Tyr?Ala?Val?Pro?Trp?Trp?Asp?Lys?Thr?Ile?Gln?Ile?Lys?Gly

665 670 675

atc?gaa?gca?tcc?acc?gta?gtg?ctc?gtg?atc?gcc?gtg?atc?gtg?ctg?atc 2179

Ile?Glu?Ala?Ser?Thr?Val?Val?Leu?Val?Ile?Ala?Val?Ile?Val?Leu?Ile

680 685 690

atc?ggt?gtt?att?caa?tcc?ttt?gtc?cac?gat?gtg?aaa?acc?gcg?caa?gcc 2227

Ile?Gly?Val?Ile?Gln?Ser?Phe?Val?His?Asp?Val?Lys?Thr?Ala?Gln?Ala

695 700 705

gaa?acc?aat?cac?tcc?atg?ggc?gaa?ctc?gtg?gcg?gaa?gat?gaa?gca?aag 2275

Glu?Thr?Asn?His?Ser?Met?Gly?Glu?Leu?Val?Ala?Glu?Asp?Glu?Ala?Lys

710 715 720 725

cgc?gag?cgt?gcc?tcc?agg?ttc?acc?ggc?ctt?gcg?gcc?tcc?cct?atc?gca 2323

Arg?Glu?Arg?Ala?Ser?Arg?Phe?Thr?Gly?Leu?Ala?Ala?Ser?Pro?Ile?Ala

730 735 740

gga?gtg?tcc?gcc?ctc?gtt?gtg?ctg?att?acc?tgc?gca?tcc?atg?ggc?aaa 2371

Gly?Val?Ser?Ala?Leu?Val?Val?Leu?Ile?Thr?Cys?Ala?Ser?Met?Gly?Lys

745 750 755

ggc?ttt?gtg?gac?caa?tac?ccc?gcg?tac?tcc?gtg?ggt?ctt?ggc?aac?ctc 2419

Gly?Phe?Val?Asp?Gln?Tyr?Pro?Ala?Tyr?Ser?Val?Gly?Leu?Gly?Asn?Leu

760 765 770

cgc?tcc?ctg?acc?ggc?aac?aca?tgt?ggc?ctt?gcc?tcc?gac?gcc?atg?ctg 2467

Arg?Ser?Leu?Thr?Gly?Asn?Thr?Cys?Gly?Leu?Ala?Ser?Asp?Ala?Met?Leu

775 780 785

gaa?acc?aac?tcc?aac?gat?tcc?ttc?ctc?act?cca?gtg?aac?tcc?aca?ctt 2515

Glu?Thr?Asn?Ser?Asn?Asp?Ser?Phe?Leu?Thr?Pro?Val?Asn?Ser?Thr?Leu

790 795 800 805

ggc?gag?tcc?ctg?gaa?tcc?gaa?gat?att?cgc?ggc?ttt?agt?gct?gcc?ggc 2563

Gly?Glu?Ser?Leu?Glu?Ser?Glu?Asp?Ile?Arg?Gly?Phe?Ser?Ala?Ala?Gly

810 815 820

atc?cca?cca?tca?atc?agc?cag?gac?caa?gca?gac?ctg?tct?gct?gtt?ggt 2611

Ile?Pro?Pro?Ser?Ile?Ser?Gln?Asp?Gln?Ala?Asp?Leu?Ser?Ala?Val?Gly

825 830 835

gcc?att?gcc?aac?act?gac?gac?tcc?acc?gaa?acc?ggc?gga?tcc?gac?gaa 2659

Ala?Ile?Ala?Asn?Thr?Asp?Asp?Ser?Thr?Glu?Thr?Gly?Gly?Ser?Asp?Glu

840 845 850

tca?tcc?gga?caa?tcc?acc?ggc?aac?acc?ggc?ggt?gtc?cga?ggc?tcc?gaa 2707

Ser?Ser?Gly?Gln?Ser?Thr?Gly?Asn?Thr?Gly?Gly?Val?Arg?Gly?Ser?Glu

855 860 865

ggc?atc?aac?ggc?tcc?aac?gcc?cgc?ctg?cca?ttc?aac?ctg?gac?tac?acc 2755

Gly?Ile?Asn?Gly?Ser?Asn?Ala?Arg?Leu?Pro?Phe?Asn?Leu?Asp?Tyr?Thr

870 875 880 885

caa?gtt?cca?gtc?gtc?ggc?tcc?tgg?tcc?gct?ggc?acc?caa?aac?cca?gca 2803

Gln?Val?Pro?Val?Val?Gly?Ser?Trp?Ser?Ala?Gly?Thr?Gln?Asn?Pro?Ala

890 895 900

aac?atc?acc?acc?gac?tgg?tac?gaa?atc?cca?gaa?gcc?acc?gaa?gaa?gca 2851

Asn?Ile?Thr?Thr?Asp?Trp?Tyr?Glu?Ile?Pro?Glu?Ala?Thr?Glu?Glu?Ala

905 910 915

ccc?atc?atc?gtg?gta?tct?gca?gca?ggt?cgc?atc?gaa?cac?tac?gac?atc 2899

Pro?Ile?Ile?Val?Val?Ser?Ala?Ala?Gly?Arg?Ile?Glu?His?Tyr?Asp?Ile

920 925 930

aac?ggc?gtc?cgc?caa?tcc?gga?caa?tcc?gtc?atg?ctc?gaa?tac?ggt?cgc 2947

Asn?Gly?Val?Arg?Gln?Ser?Gly?Gln?Ser?Val?Met?Leu?Glu?Tyr?Gly?Arg

935 940 945

ctt?cgc?gat?aac?ggc?gac?gtt?gaa?gac?ctc?ggc?gaa?gcc?atg?atg?tac 2995

Leu?Arg?Asp?Asn?Gly?Asp?Val?Glu?Asp?Leu?Gly?Glu?Ala?Met?Met?Tyr

950 955 960 965

gac?atc?ggc?ccc?gag?cca?tcc?tgg?cgc?aac?ctc?cgc?tac?cca?ctt?gac 3043

Asp?Ile?Gly?Pro?Glu?Pro?Ser?Trp?Arg?Asn?Leu?Arg?Tyr?Pro?Leu?Asp

970 975 980

caa?ctc?cca?gaa?gaa?gcg?gac?gtc?gtg?cgc?atc?gtc?gcc?acc?gac?gtc 3091

Gln?Leu?Pro?Glu?Glu?Ala?Asp?Val?Val?Arg?Ile?Val?Ala?Thr?Asp?Val

985 990 995

aac?ctc?gac gaa?gac?caa?tgg?gta gca?ctg?acg?cca?cca cgc?gta?cct?3139

Asn?Leu?Asp Glu?Asp?Gln?Trp?Val Ala?Leu?Thr?Pro?Pro Arg?Val?Pro

1000 1005 1010

aac?cta gat?tct?ctg?aac?aac gtc?atc?gga?tcc?gaa acc?cca?gga?ctc?3187

Asn?Leu Asp?Ser?Leu?Asn?Asn Val?Ile?Gly?Ser?Glu Thr?Pro?Gly?Leu

1015 1020 1025

ctc?gac?tgg?gca?gtt?ggc ctg?caa?ttc?cca?tgc caa?cgc?acc?ttc?gac 3235

Leu?Asp?Trp?Ala?Val?Gly Leu?Gln?Phe?Pro?Cys Gln?Arg?Thr?Phe?Asp

1030 1035 1040 1045

cac?tac?gcc?gga?gtc acc?gag?att?cct?gaa tac?cga?atc?tcc?cca?gac 3283

His?Tyr?Ala?Gly?Val Thr?Glu?Ile?Pro?Glu Tyr?Arg?Ile?Ser?Pro?Asp

1050 1055 1060

cac?ggc?gga?aaa tcc?acc?ctc?tcc?cea ttc?caa?gac?tgg?gca?ggc?ggc 3331

His?Gly?Gly?Lys Ser?Thr?Leu?Ser?Pro Phe?Gln?Asp?Trp?Ala?Gly?Gly

1065 1070 1075

gga?tcc?atg ggc?acg?gcc?gaa?gca gta?aac?aac?gcc?tac gaa?atc?ccg?3379

Gly?Ser?Met Gly?Thr?Ala?Glu?Ala Val?Asn?Asn?Ala?Tyr Glu?Ile?Pro

1080 1085 1090

tcc?tac ctc?cgc?aac?gac?tgg ggc?cgc?gac?tgg?ggt tcc?atc?gaa?cgc?3427

Ser?Tyr Leu?Arg?Asn?Asp?Trp Gly?Arg?Asp?Trp?Gly Ser?Ile?Glu?Arg

1095 1100 1105

tac?tcg ctg?cgc?acc?aac tcc?aac?ggc?gat?gca cct?aag?gtt?gca?gac 3475

Tyr?Ser Leu?Arg?Thr?Asn Ser?Asn?Gly?Asp?Ala Pro?Lys?Val?Ala?Asp

1110 1115 1120 1125

atc?aac?ctt?gaa?acc atc?caa?cgt?tcc?gga ctc?tgg?aat?cca?ggg cat 3523

Ile?Asn?Leu?Glu?Thr Ile?Gln?Arg?Ser?Gly Leu?Trp?Asn?Pro?Gly His

1130 1135 1140

atg?aag?gta?gat gaa?taagaccttc?agtactggaa?gtt 3561

Met?Lys?Val?Asp Glu

1145

<210>476

<211>1146

<212>PRT

＜213〉Corynebacterium glutamicum

<400>476

Met?Arg?Gln?Val?Gly?Gly?Asn?Gly?Gly?His?Gln?Leu?Asp?Ser?Ile?Asn

1 5 10 15

Val?Ser?Asp?Val?Val?Glu?Ser?Lys?Lys?Leu?Lys?Gly?Ser?Ala?Gln?Glu

20 25 30

Pro?Pro?Gln?Val?Ala?Pro?Gly?Trp?Leu?Lys?Lys?Leu?Ala?Ile?Ser?Ser

35 40 45

Gly?Leu?Leu?Gly?Leu?Leu?Met?Phe?Val?Leu?Leu?Pro?Phe?Leu?Pro?Val

50 55 60

Asn?Gln?Val?Gln?Ser?Ser?Leu?Ser?Trp?Pro?Gln?Asn?Gly?Glu?Leu?Ser

65 70 75 80

Ser?Val?Asn?Ala?Pro?Leu?Ile?Ser?Tyr?Ala?Pro?Gln?Ser?Met?Asp?Ala

85 90 95

Ser?Ile?Pro?Val?Ser?Ala?Leu?Asp?Ser?Leu?Asn?Asp?Asn?Gln?Ser?Leu

100 105 110

Val?Met?Gly?Thr?Leu?Pro?Leu?Asp?Ser?Thr?Asp?Ala?Thr?Asn?Arg?Gly

115 120 125

Leu?Phe?Val?Arg?Thr?Ile?Asp?Gly?Asn?Leu?Asp?Val?Ile?Val?Arg?Gly

130 135 140

Glu?Val?Leu?Leu?Asp?Leu?Ser?Pro?Thr?Glu?Val?Asn?Arg?Leu?Pro?Asp

145 150 155 160

Asp?Ala?Ile?Leu?Glu?Ile?Ser?Ser?Thr?Glu?Glu?Thr?Thr?Ser?Ala?Glu

165 170 175

Ile?Thr?Gly?Thr?Ala?Phe?Ser?Gly?Glu?Thr?Glu?Gly?Asp?Glu?Arg?Pro

180 185 190

Gln?Val?Thr?Gly?Val?Tyr?Thr?Glu?Leu?Val?Asp?Asp?Pro?Ser?Thr?Ala

195 200 205

Ser?Ala?Leu?Ala?Ser?Ala?Gly?Leu?Asn?Val?Asp?Ile?Glu?Ile?Asn?Ser

210 215 220

Arg?Phe?Thr?Ser?Ser?Pro?Ser?Leu?Leu?Lys?Tyr?Ala?Ala?Ile?Phe?Ile

225 230 235 240

Gly?Leu?Ala?Ser?Val?Leu?Val?Ser?Leu?Trp?Thr?Leu?His?Arg?Met?Asp

245 250 255

Ile?Leu?Asp?Gly?Arg?Lys?Ala?His?Arg?Phe?Leu?Pro?Ala?Asn?Trp?Tyr

260 265 270

Lys?Leu?Lys?Pro?Leu?Asp?Gly?Val?Val?Val?Ala?Ile?Leu?Val?Phe?Trp

275 280 285

His?Phe?Leu?Gly?Ala?Asn?Thr?Ser?Asp?Asp?Gly?Phe?Ile?Met?Thr?Met

290 295 300

Ala?Arg?Val?Ser?Gln?Asn?Ala?Asp?Tyr?Met?Ala?Asn?Tyr?Tyr?Arg?Trp

305 310 315 320

Phe?Gly?Val?Pro?Glu?Ser?Pro?Phe?Gly?Ala?Pro?Tyr?Tyr?Asp?Leu?Leu

325 330 335

Ala?Leu?Met?Ala?Tyr?Ile?Ser?Thr?Ser?Ser?Ile?Trp?Leu?Arg?Leu?Pro

340 345 350

Ala?Leu?Leu?Ala?Gly?Leu?Ile?Met?Trp?Phe?Val?Ile?Thr?Arg?Glu?Val

355 360 365

Met?Pro?Arg?Phe?Gly?Ser?Leu?Val?Asn?Gly?Arg?Arg?Val?Ala?His?Trp

370 375 380

Ser?Ala?Ala?Met?Val?Phe?Leu?Ala?Phe?Trp?Leu?Pro?Tyr?Asn?Asn?Gly

385 390 395 400

Thr?Arg?Pro?Glu?Pro?Ile?Ile?Ala?Met?Gly?Ala?Leu?Leu?Ala?Trp?Val

405 410 415

Ser?Phe?Glu?Arg?Ala?Ile?Ala?Thr?Ser?Arg?Leu?Leu?Pro?Ala?Ala?Ile

420 425 430

Gly?Val?Ile?Ile?Ala?Thr?Ile?Ser?Leu?Ala?Ser?Gly?Pro?Thr?Gly?Leu

435 440 445

Met?Ala?Val?Ala?Ala?Leu?Leu?Val?Ser?Leu?Ser?Ala?Leu?Ile?Arg?Ile

450 455 460

Leu?Tyr?Arg?Arg?Leu?Pro?Leu?Ile?Gly?Ala?Ser?Arg?Gly?Ala?Ser?Lys

465 470 475 480

Ser?Lys?Val?Phe?Gly?Ala?Ser?Met?Ala?Met?Leu?Ala?Pro?Phe?Leu?Ala

485 490 495

Ser?Gly?Thr?Ala?Ile?Leu?Ile?Ala?Val?Phe?Gly?Asp?Gln?Thr?Leu?Ser

500 505 510

Thr?Val?Met?Glu?Ser?Ile?Ser?Val?Arg?Ser?Ala?Lys?Gly?Pro?Ala?Leu

515 520 525

Thr?Trp?Tyr?His?Glu?Tyr?Val?Arg?Tyr?Gln?Thr?Val?Met?Glu?Gln?Thr

530 535 540

Val?Asp?Gly?Ser?Phe?Thr?Arg?Arg?Phe?Ala?Val?Leu?Met?Leu?Met?Ala

545 550 555 560

Cys?Leu?Ala?Ile?Val?Val?Ile?Ala?Ile?Leu?Arg?Tyr?Gly?Arg?Ile?Pro

565 570 575

Gly?Ala?Ala?Lys?Gly?Pro?Ser?Leu?Arg?Leu?Met?Met?Val?Ile?Phe?Gly

580 585 590

Thr?Met?Phe?Phe?Met?Met?Phe?Thr?Pro?Thr?Lys?Trp?Thr?His?His?Phe

595 600 605

Gly?Val?Tyr?Ala?Gly?Leu?Ala?Gly?Ala?Leu?Ala?Gly?Leu?Ala?Ala?Val

610 615 620

Gly?Leu?Ser?Tyr?Val?Ala?Val?Lys?Ser?Pro?Arg?Met?Arg?Thr?Ile?Ser

625 630 635 640

Ile?Gly?Ala?Phe?Leu?Phe?Leu?Leu?Ala?Leu?Ala?Leu?Ala?Gly?Val?Asn

645 650 655

Gly?Phe?Trp?Tyr?Thr?Ser?Ser?Tyr?Ala?Val?Pro?Trp?Trp?Asp?Lys?Thr

660 665 670

Ile?Gln?Ile?Lys?Gly?Ile?Glu?Ala?Ser?Thr?Val?Val?Leu?Val?Ile?Ala

675 680 685

Val?Ile?Val?Leu?Ile?Ile?Gly?Val?Ile?Gln?Ser?Phe?Val?His?Asp?Val

690 695 700

Lys?Thr?Ala?Gln?Ala?Glu?Thr?Asn?His?Ser?Met?Gly?Glu?Leu?Val?Ala

705 710 715 720

Glu?Asp?Glu?Ala?Lys?Arg?Glu?Arg?Ala?Ser?Arg?Phe?Thr?Gly?Leu?Ala

725 730 735

Ala?Ser?Pro?Ile?Ala?Gly?Val?Ser?Ala?Leu?Val?Val?Leu?Ile?Thr?Cys

740 745 750

Ala?Ser?Met?Gly?Lys?Gly?Phe?Val?Asp?Gln?Tyr?Pro?Ala?Tyr?Ser?Val

755 760 765

Gly?Leu?Gly?Asn?Leu?Arg?Ser?Leu?Thr?Gly?Asn?Thr?Cys?Gly?Leu?Ala

770 775 780

Ser?Asp?Ala?Met?Leu?Glu?Thr?Asn?Ser?Asn?Asp?Ser?Phe?Leu?Thr?Pro

785 790 795 800

Val?Asn?Ser?Thr?Leu?Gly?Glu?Ser?Leu?Glu?Ser?Glu?Asp?Ile?Arg?Gly

805 810 815

Phe?Ser?Ala?Ala?Gly?Ile?Pro?Pro?Ser?Ile?Ser?Gln?Asp?Gln?Ala?Asp

820 825 830

Leu?Ser?Ala?Val?Gly?Ala?Ile?Ala?Asn?Thr?Asp?Asp?Ser?Thr?Glu?Thr

835 840 845

Gly?Gly?Ser?Asp?Glu?Ser?Ser?Gly?Gln?Ser?Thr?Gly?Asn?Thr?Gly?Gly

850 855 860

Val?Arg?Gly?Ser?Glu?Gly?Ile?Asn?Gly?Ser?Asn?Ala?Arg?Leu?Pro?Phe

865 870 875 880

Asn?Leu?Asp?Tyr?Thr?Gln?Val?Pro?Val?Val?Gly?Ser?Trp?Ser?Ala?Gly

885 890 895

Thr?Gln?Asn?Pro?Ala?Asn?Ile?Thr?Thr?Asp?Trp?Tyr?Glu?Ile?Pro?Glu

900 905 910

Ala?Thr?Glu?Glu?Ala?Pro?Ile?Ile?Val?Val?Ser?Ala?Ala?Gly?Arg?Ile

915 920 925

Glu?His?Tyr?Asp?Ile?Asn?Gly?Val?Arg?Gln?Ser?Gly?Gln?Ser?Val?Met

930 935 940

Leu?Glu?Tyr?Gly?Arg?Leu?Arg?Asp?Asn?Gly?Asp?Val?Glu?Asp?Leu?Gly

945 950 955 960

Glu?Ala?Met?Met?Tyr?Asp?Ile?Gly?Pro?Glu?Pro?Ser?Trp?Arg?Asn?Leu

965 970 975

Arg?Tyr?Pro?Leu?Asp?Gln?Leu?Pro?Glu?Glu?Ala?Asp?Val?Val?Arg?Ile

980 985 990

Val?Ala?Thr?Asp?Val?Asn?Leu?Asp Glu?Asp?Gln?Trp?Val Ala?Leu?Thr

995 1000 1005

Pro?Pro Arg?Val?Pro?Asn?Leu Asp?Ser?Leu?Asn?Asn Val?Ile?Gly?Ser

1010 1015 1020

Glu Thr?Pro?Gly?Leu?Leu Asp?Trp?Ala?Val?Gly Leu?Gln?Phe?Pro?Cys

1025 1030 1035 1040

Gln?Arg?Thr?Phe?Asp His?Tyr?Ala?Gly?Val Thr?Glu?Ile?Pro?Glu Tyr

1045 1050 1055

Arg?Ile?Ser?Pro Asp?His?Gly?Gly?Lys Ser?Thr?Leu?Ser?Pro Phe?Gln

1060 1065 1070

Asp?Trp?Ala Gly?Gly?Gly?Ser?Met Gly?Thr?Ala?Glu?Ala Val?Asn?Asn

1075 1080 1085

Ala?Tyr Glu?Ile?Pro?Ser?Tyr Leu?Arg?Asn?Asp?Trp Gly?Arg?Asp?Trp

1090 1095 1100

Gly Ser?Ile?Glu?Arg?Tyr Ser?Leu?Arg?Thr?Asn Ser?Asn?Gly?Asp?Ala

1105 1110 1115 1120

Pro?Lys?Val?Ala?Asp Ile?Asn?Leu?Glu?Thr Ile?Gln?Arg?Ser?Gly Leu

1125 1130 1135

Trp?Asn?Pro?Gly His?Met?Lys?Val?Asp Glu

1140 1145

<210>477

<211>1509

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1486)

<223>RXN01175

<400>477

tcgcgtctct?tagtcgatct?gctcccattc?cataggttgg?gagaaaactt?aactgttatt?60

ccattcctta?aaacaccgat?atcgtgctat?gaataggggt?gtg?agt?tgg?aca?gtt 115

Val?Ser?Trp?Thr?Val

1 5

gat?atc?cct?aaa?gaa?gtt?ctc?cct?gat?ttg?cca?cca?ttg?cca?gaa?ggc 163

Asp?Ile?Pro?Lys?Glu?Val?Leu?Pro?Asp?Leu?Pro?Pro?Leu?Pro?Glu?Gly

10 15 20

atg?cag?cag?cag?ttc?gag?gac?acc?att?tcc?cgt?gac?gct?aag?cag?caa 211

Met?Gln?Gln?Gln?Phe?Glu?Asp?Thr?Ile?Ser?Arg?Asp?Ala?Lys?Gln?Gln

25 30 35

cct?acg?tgg?gat?cgt?gca?cag?gca?gaa?aac?gtg?cgc?aag?atc?ctt?gag 259

Pro?Thr?Trp?Asp?Arg?Ala?Gln?Ala?Glu?Asn?Val?Arg?Lys?Ile?Leu?Glu

40 45 50

tcg?gtt?cct?cca?atc?gtt?gtt?gcc?cct?gag?gta?ctt?gag?ctg?aag?cag 307

Ser?Val?Pro?Pro?Ile?Val?Val?Ala?Pro?Glu?Val?Leu?Glu?Leu?Lys?Gln

55 60 65

aag?ctt?gct?gat?gtt?gcc?aac?ggt?aag?gcc?ttc?ctc?ttg?cag?ggt?ggt 355

Lys?Leu?Ala?Asp?Val?Ala?Asn?Gly?Lys?Ala?Phe?Leu?Leu?Gln?Gly?Gly

70 75 80 85

gac?tgt?gcg?gaa?act?ttc?gag?tca?aac?act?gag?ccg?cac?att?cgc?gcc 403

Asp?Cys?Ala?Glu?Thr?Phe?Glu?Ser?Asn?Thr?Glu?Pro?His?Ile?Arg?Ala

90 95 100

aac?gta?aag?act?ctg?ctg?cag?atg?gca?gtt?gtt?ttg?acc?tac?ggt?gca 451

Asn?Val?Lys?Thr?Leu?Leu?Gln?Met?Ala?Val?Val?Leu?Thr?Tyr?Gly?Ala

105 110 115

tcc?act?cct?gtg?atc?aag?atg?gct?cgt?att?gct?ggt?cag?tac?gca?aag 499

Ser?Thr?Pro?Val?Ile?Lys?Met?Ala?Arg?Ile?Ala?Gly?Gln?Tyr?Ala?Lys

120 125 130

cct?cgc?tct?tct?gat?ctg?gat?gga?aat?ggt?ctg?cca?aac?tac?cgt?ggc 547

Pro?Arg?Ser?Ser?Asp?Leu?Asp?Gly?Asn?Gly?Leu?Pro?Asn?Tyr?Arg?Gly

135 140 145

gat?atc?gtc?aac?ggt?gtg?gag?gca?acc?cca?gag?gct?cgt?cgc?cac?gat 595

Asp?Ile?Val?Asn?Gly?Val?Glu?Ala?Thr?Pro?Glu?Ala?Arg?Arg?His?Asp

150 155 160 165

cct?gcc?cgc?atg?atc?cgt?gct?tac?gct?aac?gct?tct?gct?gcg?atg?aac 643

Pro?Ala?Arg?Met?Ile?Arg?Ala?Tyr?Ala?Asn?Ala?Ser?Ala?Ala?Met?Asn

170 175 180

ttg?gtg?cgc?gcg?ctc?acc?agc?tct?ggc?acc?gct?gat?ctt?tac?cgt?ctc 691

Leu?Val?Arg?Ala?Leu?Thr?Ser?Ser?Gly?Thr?Ala?Asp?Leu?Tyr?Arg?Leu

185 190 195

agc?gag?tgg?aac?cgc?gag?ttc?gtt?gcg?aac?tcc?cca?gct?ggt?gca?cgc 739

Ser?Glu?Trp?Asn?Arg?Glu?Phe?Val?Ala?Asn?Ser?Pro?Ala?Gly?Ala?Arg

200 205 210

tac?gag?gct?ctt?gct?cgt?gag?atc?gac?tcc?ggt?ctg?cgc?ttc?atg?gaa 787

Tyr?Glu?Ala?Leu?Ala?Arg?Glu?Ile?Asp?Ser?Gly?Leu?Arg?Phe?Met?Glu

215 220 225

gca?tgt?ggc?gtg?tcc?gat?gag?tcc?ctg?cgt?gct?gca?gat?atc?tac?tgc 835

Ala?Cys?Gly?Val?Ser?Asp?Glu?Ser?Leu?Arg?Ala?Ala?Asp?Ile?Tyr?Cys

230 235 240 245

tcc?cac?gag?gct?ttg?ctg?gtg?gat?tac?gag?cgt?tcc?atg?ctg?cgt?ctt 883

Ser?His?Glu?Ala?Leu?Leu?Val?Asp?Tyr?Glu?Arg?Ser?Met?Leu?Arg?Leu

250 255 260

gca?acc?gat?gag?gaa?ggc?aac?gag?gaa?ctt?tac?gat?ctt?tca?gct?cac 931

Ala?Thr?Asp?Glu?Glu?Gly?Asn?Glu?Glu?Leu?Tyr?Asp?Leu?Ser?Ala?His

265 270 275

cag?ctg?tgg?atc?ggc?gag?cgc?acc?cgt?ggc?atg?gat?gat?ttc?cat?gtg 979

Gln?Leu?Trp?Ile?Gly?Glu?Arg?Thr?Arg?Gly?Met?Asp?Asp?Phe?His?Val

280 285 290

aac?ttc?gca?tcc?atg?atc?tct?aac?cca?atc?ggc?atc?aag?att?ggt?cct 1027

Asn?Phe?Ala?Ser?Met?Ile?Ser?Asn?Pro?Ile?Gly?Ile?Lys?Ile?Gly?Pro

295 300 305

ggt?atc?acc?cct?gaa?gag?gct?gtt?gca?tac?gct?gac?aag?ctc?gat?ccg 1075

Gly?Ile?Thr?Pro?Glu?Glu?Ala?Val?Ala?Tyr?Ala?Asp?Lys?Leu?Asp?Pro

310 315 320 325

aac?ttc?gag?cct?ggc?cgt?ttg?acc?atc?gtt?gct?cgc?atg?ggc?cac?gac 1123

Asn?Phe?Glu?Pro?Gly?Arg?Leu?Thr?Ile?Val?Ala?Arg?Met?Gly?His?Asp

330 335 340

aag?gtt?cgc?tcc?gta?ctt?cct?ggt?gtt?atc?cag?gct?gtt?gag?gca?tcc 1171

Lys?Val?Arg?Ser?Val?Leu?Pro?Gly?Val?Ile?Gln?Ala?Val?Glu?Ala?Ser

345 350 355

gga?cac?aag?gtt?att?tgg?cag?tcc?gat?ccg?atg?cac?ggc?aac?act?ttc 1219

Gly?His?Lys?Val?Ile?Trp?Gln?Ser?Asp?Pro?Met?His?Gly?Asn?Thr?Phe

360 365 370

acc?gca?tcc?aat?ggc?tac?aag?acc?cgt?cac?ttc?gac?aag?gtt?atc?gat 1267

Thr?Ala?Ser?Asn?Gly?Tyr?Lys?Thr?Arg?His?Phe?Asp?Lys?Val?Ile?Asp

375 380 385

gag?gtc?cag?ggc?ttc?ttc?gag?gtc?cac?cgc?gca?ttg?ggc?acc?cac?cca 1315

Glu?Val?Gln?Gly?Phe?Phe?Glu?Val?His?Arg?Ala?Leu?Gly?Thr?His?Pro

390 395 400 405

ggc?gga?atc?cac?att?gag?ttc?act?ggt?gaa?gat?gtc?acc?gag?tgc?ctc 1363

Gly?Gly?Ile?His?Ile?Glu?Phe?Thr?Gly?Glu?Asp?Val?Thr?Glu?Cys?Leu

410 415 420

ggt?ggc?gct?gaa?gac?atc?acc?gat?gtt?gat?ctg?cca?ggc?cgc?tac?gag 1411

Gly?Gly?Ala?Glu?Asp?Ile?Thr?Asp?Val?Asp?Leu?Pro?Gly?Arg?Tyr?Glu

425 430 435

tcc?gca?tgc?gat?cct?cgc?ctg?aac?act?cag?cag?tct?ttg?gag?ttg?gct 1459

Ser?Ala?Cys?Asp?Pro?Arg?Leu?Asn?Thr?Gln?Gln?Ser?Leu?Glu?Leu?Ala

440 445 450

ttc?ctc?gtt?gca?gaa?atg?ctg?cgt?aac?taagctttta?gaccaactct 1506

Phe?Leu?Val?Ala?Glu?Met?Leu?Arg?Asn

455 460

aaa 1509

<210>478

<211>462

<212>PRT

＜213〉Corynebacterium glutamicum

<400>478

Val?Ser?Trp?Thr?Val?Asp?Ile?Pro?Lys?Glu?Val?Leu?Pro?Asp?Leu?Pro

1 5 10 15

Pro?Leu?Pro?Glu?Gly?Met?Gln?Gln?Gln?Phe?Glu?Asp?Thr?Ile?Ser?Arg

20 25 30

Asp?Ala?Lys?Gln?Gln?Pro?Thr?Trp?Asp?Arg?Ala?Gln?Ala?Glu?Asn?Val

35 40 45

Arg?Lys?Ile?Leu?Glu?Ser?Val?Pro?Pro?Ile?Val?Val?Ala?Pro?Glu?Val

50 55 60

Leu?Glu?Leu?Lys?Gln?Lys?Leu?Ala?Asp?Val?Ala?Asn?Gly?Lys?Ala?Phe

65 70 75 80

Leu?Leu?Gln?Gly?Gly?Asp?Cys?Ala?Glu?Thr?Phe?Glu?Ser?Asn?Thr?Glu

85 90 95

Pro?His?Ile?Arg?Ala?Asn?Val?Lys?Thr?Leu?Leu?Gln?Met?Ala?Val?Val

100 105 110

Leu?Thr?Tyr?Gly?Ala?Ser?Thr?Pro?Val?Ile?Lys?Met?Ala?Arg?Ile?Ala

115 120 125

Gly?Gln?Tyr?Ala?Lys?Pro?Arg?Ser?Ser?Asp?Leu?Asp?Gly?Asn?Gly?Leu

130 135 140

Pro?Asn?Tyr?Arg?Gly?Asp?Ile?Val?Asn?Gly?Val?Glu?Ala?Thr?Pro?Glu

145 150 155 160

Ala?Arg?Arg?His?Asp?Pro?Ala?Arg?Met?Ile?Arg?Ala?Tyr?Ala?Asn?Ala

165 170 175

Ser?Ala?Ala?Met?Asn?Leu?Val?Arg?Ala?Leu?Thr?Ser?Ser?Gly?Thr?Ala

180 185 190

Asp?Leu?Tyr?Arg?Leu?Ser?Glu?Trp?Asn?Arg?Glu?Phe?Val?Ala?Asn?Ser

195 200 205

Pro?Ala?Gly?Ala?Arg?Tyr?Glu?Ala?Leu?Ala?Arg?Glu?Ile?Asp?Ser?Gly

210 215 220

Leu?Arg?Phe?Met?Glu?Ala?Cys?Gly?Val?Ser?Asp?Glu?Ser?Leu?Arg?Ala

225 230 235 240

Ala?Asp?Ile?Tyr?Cys?Ser?His?Glu?Ala?Leu?Leu?Val?Asp?Tyr?Glu?Arg

245 250 255

Ser?Met?Leu?Arg?Leu?Ala?Thr?Asp?Glu?Glu?Gly?Asn?Glu?Glu?Leu?Tyr

260 265 270

Asp?Leu?Ser?Ala?His?Gln?Leu?Trp?Ile?Gly?Glu?Arg?Thr?Arg?Gly?Met

275 280 285

Asp?Asp?Phe?His?Val?Asn?Phe?Ala?Ser?Met?Ile?Ser?Asn?Pro?Ile?Gly

290 295 300

Ile?Lys?Ile?Gly?Pro?Gly?Ile?Thr?Pro?Glu?Glu?Ala?Val?Ala?Tyr?Ala

305 310 315 320

Asp?Lys?Leu?Asp?Pro?Asn?Phe?Glu?Pro?Gly?Arg?Leu?Thr?Ile?Val?Ala

325 330 335

Arg?Met?Gly?His?Asp?Lys?Val?Arg?Ser?Val?Leu?Pro?Gly?Val?Ile?Gln

340 345 350

Ala?Val?Glu?Ala?Ser?Gly?His?Lys?Val?Ile?Trp?Gln?Ser?Asp?Pro?Met

355 360 365

His?Gly?Asn?Thr?Phe?Thr?Ala?Ser?Asn?Gly?Tyr?Lys?Thr?Arg?His?Phe

370 375 380

Asp?Lys?Val?Ile?Asp?Glu?Val?Gln?Gly?Phe?Phe?Glu?Val?His?Arg?Ala

385 390 395 400

Leu?Gly?Thr?His?Pro?Gly?Gly?Ile?His?Ile?Glu?Phe?Thr?Gly?Glu?Asp

405 410 415

Val?Thr?Glu?Cys?Leu?Gly?Gly?Ala?Glu?Asp?Ile?Thr?Asp?Val?Asp?Leu

420 425 430

Pro?Gly?Arg?Tyr?Glu?Ser?Ala?Cys?Asp?Pro?Arg?Leu?Asn?Thr?Gln?Gln

435 440 445

Ser?Leu?Glu?Leu?Ala?Phe?Leu?Val?Ala?Glu?Met?Leu?Arg?Asn

450 455 460

<210>479

<211>984

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(961)

<223>RXN01376

<400>479

tcctcatcgg?ttatcgggag?tggcggatac?ttcttgcaaa?cttaaaccac?tatgctttcg?60

cttcgtgagt?actttgaaat?cccccatcgc?tgtgatcaca?gtg?acc?tat?tca?cca 115

Val?Thr?Tyr?Ser?Pro

1 5

ggt?aaa?tac?ttg?gcg?tcg?ttc?ctg?gat?tct?ttg?cct?ggt?gcg?act?tca 163

Gly?Lys?Tyr?Leu?Ala?Ser?Phe?Leu?Asp?Ser?Leu?Pro?Gly?Ala?Thr?Ser

10 15 20

cga?gac?acc?cac?gtt?gtg?atg?gca?gac?aat?ggt?tct?gtg?gac?ggt?gtt 211

Arg?Asp?Thr?His?Val?Val?Met?Ala?Asp?Asn?Gly?Ser?Val?Asp?Gly?Val

25 30 35

cct?gag?cag?gca?gca?gcc?tca?cgc?agc?aac?gtg?gag?ttc?ctc?tca?act 259

Pro?Glu?Gln?Ala?Ala?Ala?Ser?Arg?Ser?Asn?Val?Glu?Phe?Leu?Ser?Thr

40 45 50

ggc?ggc?aac?tta?ggc?tac?gga?acg?gct?att?aat?att?gcc?gcc?cga?tcg 307

Gly?Gly?Asn?Leu?Gly?Tyr?Gly?Thr?Ala?Ile?Asn?Ile?Ala?Ala?Arg?Ser

55 60 65

ttg?cgt?gcg?cgc?cgg?gag?gca?gga?gag?atc?gat?ggg?gag?ttc?ttc?ctc 355

Leu?Arg?Ala?Arg?Arg?Glu?Ala?Gly?Glu?Ile?Asp?Gly?Glu?Phe?Phe?Leu

70 75 80 85

gtc?tca?aac?cct?gat?gtt?gtt?ttt?gac?gaa?gac?tct?att?gat?caa?ttg 403

Val?Ser?Asn?Pro?Asp?Val?Val?Phe?Asp?Glu?Asp?Ser?Ile?Asp?Gln?Leu

90 95 100

ctt?gaa?tgt?gcg?aaa?cgt?cac?cct?gaa?gca?gga?gcg?gtt?ggc?ccg?ttg 451

Leu?Glu?Cys?Ala?Lys?Arg?His?Pro?Glu?Ala?Gly?Ala?Val?Gly?Pro?Leu

105 110 115

atc?cgt?gag?gcg?gac?ggt?tcg?gcg?tat?ccg?tcg?gct?cgg?gcg?gta?ccc 499

Ile?Arg?Glu?Ala?Asp?Gly?Ser?Ala?Tyr?Pro?Ser?Ala?Arg?Ala?Val?Pro

120 125 130

act?ttg?gcg?aat?ggc?att?ggt?cac?gct?ttg?ttg?ggt?gct?gtg?tgg?aaa 547

Thr?Leu?Ala?Asn?Gly?Ile?Gly?His?Ala?Leu?Leu?Gly?Ala?Val?Trp?Lys

135 140 145

tcc?aat?ccg?tgg?tcg?gcg?gct?tac?cgt?gac?gat?gaa?gat?atg?gac?act 595

Ser?Asn?Pro?Trp?Ser?Ala?Ala?Tyr?Arg?Asp?Asp?Glu?Asp?Met?Asp?Thr

150 155 160 165

gag?cgc?act?gct?ggc?tgg?ctg?tcg?gga?tcg?tgc?ctg?tta?tta?agg?tgg 643

Glu?Arg?Thr?Ala?Gly?Trp?Leu?Ser?Gly?Ser?Cys?Leu?Leu?Leu?Arg?Trp

170 175 180

gat?gcg?ttt?gat?cga?gtt?ggt?ggt?ttt?gat?gag?cgc?tac?ttc?atg?tac 691

Asp?Ala?Phe?Asp?Arg?Val?Gly?Gly?Phe?Asp?Glu?Arg?Tyr?Phe?Met?Tyr

185 190 195

atg?gaa?gac?gtt?gac?ctg?gga?gat?cgg?ctg?gtt?cgc?gcc?ggt?ttc?acc 739

Met?Glu?Asp?Val?Asp?Leu?Gly?Asp?Arg?Leu?Val?Arg?Ala?Gly?Phe?Thr

200 205 210

aac?gtc?ttt?tgc?cca?agt?gcg?cag?atc?atc?cac?gcg?aaa?ggt?cat?gtt 787

Asn?Val?Phe?Cys?Pro?Ser?Ala?Gln?Ile?Ile?His?Ala?Lys?Gly?His?Val

215 220 225

gcg?ggt?aaa?aac?cca?gag?aac?atg?ttg?ccc?gca?cac?cac?gag?agc?gcg 835

Ala?Gly?Lys?Asn?Pro?Glu?Asn?Met?Leu?Pro?Ala?His?His?Glu?Ser?Ala

230 235 240 245

tat?cgc?ttc?cag?gct?gat?cgc?ctc?gcg?aag?ccg?tgg?caa?gcc?cca?att 883

Tyr?Arg?Phe?Gln?Ala?Asp?Arg?Leu?Ala?Lys?Pro?Trp?Gln?Ala?Pro?Ile

250 255 260

cgg?ttg?gct?ctg?cga?att?ggt?ttg?aaa?tta?cga?gcc?gga?gtc?gcg?gtt 931

Arg?Leu?Ala?Leu?Arg?Ile?Gly?Leu?Lys?Leu?Arg?Ala?Gly?Val?Ala?Val

265 270 275

ggt?gtc?tct?aag?atg?aga?acg?aaa?gcc?tct?tagaccgtcg?acgaccaccg 981

Gly?Val?Ser?Lys?Met?Arg?Thr?Lys?Ala?Ser

280 285

gac 984

<210>480

<211>287

<212>PRT

＜213〉Corynebacterium glutamicum

<400>480

Val?Thr?Tyr?Ser?Pro?Gly?Lys?Tyr?Leu?Ala?Ser?Phe?Leu?Asp?Ser?Leu

1 5 10 15

Pro?Gly?Ala?Thr?Ser?Arg?Asp?Thr?His?Val?Val?Met?Ala?Asp?Asn?Gly

20 25 30

Ser?Val?Asp?Gly?Val?Pro?Glu?Gln?Ala?Ala?Ala?Ser?Arg?Ser?Asn?Val

35 40 45

Glu?Phe?Leu?Ser?Thr?Gly?Gly?Asn?Leu?Gly?Tyr?Gly?Thr?Ala?Ile?Asn

50 55 60

Ile?Ala?Ala?Arg?Ser?Leu?Arg?Ala?Arg?Arg?Glu?Ala?Gly?Glu?Ile?Asp

65 70 75 80

Gly?Glu?Phe?Phe?Leu?Val?Ser?Asn?Pro?Asp?Val?Val?Phe?Asp?Glu?Asp

85 90 95

Ser?Ile?Asp?Gln?Leu?Leu?Glu?Cys?Ala?Lys?Arg?His?Pro?Glu?Ala?Gly

100 105 110

Ala?Val?Gly?Pro?Leu?Ile?Arg?Glu?Ala?Asp?Gly?Ser?Ala?Tyr?Pro?Ser

115 120 125

Ala?Arg?Ala?Val?Pro?Thr?Leu?Ala?Asn?Gly?Ile?Gly?His?Ala?Leu?Leu

130 135 140

Gly?Ala?Val?Trp?Lys?Ser?Asn?Pro?Trp?Ser?Ala?Ala?Tyr?Arg?Asp?Asp

145 150 155 160

Glu?Asp?Met?Asp?Thr?Glu?Arg?Thr?Ala?Gly?Trp?Leu?Ser?Gly?Ser?Cys

165 170 175

Leu?Leu?Leu?Arg?Trp?Asp?Ala?Phe?Asp?Arg?Val?Gly?Gly?Phe?Asp?Glu

180 185 190

Arg?Tyr?Phe?Met?Tyr?Met?Glu?Asp?Val?Asp?Leu?Gly?Asp?Arg?Leu?Val

195 200 205

Arg?Ala?Gly?Phe?Thr?Asn?Val?Phe?Cys?Pro?Ser?Ala?Gln?Ile?Ile?His

210 215 220

Ala?Lys?Gly?His?Val?Ala?Gly?Lys?Asn?Pro?Glu?Asn?Met?Leu?Pro?Ala

225 230 235 240

His?His?Glu?Ser?Ala?Tyr?Arg?Phe?Gln?Ala?Asp?Arg?Leu?Ala?Lys?Pro

245 250 255

Trp?Gln?Ala?Pro?Ile?Arg?Leu?Ala?Leu?Arg?Ile?Gly?Leu?Lys?Leu?Arg

260 265 270

Ala?Gly?Val?Ala?Val?Gly?Val?Ser?Lys?Met?Arg?Thr?Lys?Ala?Ser

275 280 285

<210>481

<211>1002

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(979)

<223>RXN01631

<400>481

gccagttgag?gatgctctca?cagtcgctcg?cattgtcagt?gcatgctacg?aatccgacaa?60

caaccagggc?atttccgtaa?acatctaaga?ggagcactcc?atg?aaa?cca?caa?ctt 115

Met?Lys?Pro?Gln?Leu

1 5

att?gca?tct?tgc?tgg?acc?agc?gcg?gga?gac?gcc?gca?ccc?gat?cgt?gac 163

Ile?Ala?Ser?Cys?Trp?Thr?Ser?Ala?Gly?Asp?Ala?Ala?Pro?Asp?Arg?Asp

10 15 20

gat?ctc?agc?agc?cca?gta?gca?atc?gat?gag?cgc?atc?gct?cta?gtc?gct 211

Asp?Leu?Ser?Ser?Pro?Val?Ala?Ile?Asp?Glu?Arg?Ile?Ala?Leu?Val?Ala

25 30 35

gaa?acc?ggt?tgg?gca?ggc?att?ggg?ctt?gtt?cac?gcc?gat?ctc?atc?aaa 259

Glu?Thr?Gly?Trp?Ala?Gly?Ile?Gly?Leu?Val?His?Ala?Asp?Leu?Ile?Lys

40 45 50

gca?cgc?gac?acc?att?ggc?tac?gag?gaa?ttg?cgc?cga?cgc?atc?cac?gct 307

Ala?Arg?Asp?Thr?Ile?Gly?Tyr?Glu?Glu?Leu?Arg?Arg?Arg?Ile?His?Ala

55 60 65

gca?gga?att?gaa?atc?att?gag?gtg?gag?ttc?ctc?aat?ggt?tgg?tgg?gcg 355

Ala?Gly?Ile?Glu?Ile?Ile?Glu?Val?Glu?Phe?Leu?Asn?Gly?Trp?Trp?Ala

70 75 80 85

act?ggt?gcg?gaa?cgc?caa?gag?tcc?gat?gcc?gtt?cgt?gcg?gat?ctg?ttt 403

Thr?Gly?Ala?Glu?Arg?Gln?Glu?Ser?Asp?Ala?Val?Arg?Ala?Asp?Leu?Phe

90 95 100

gct?gcg?gcg?caa?gct?ctt?ggt?tcc?cca?cac?att?aag?gtc?gga?gca?gga 451

Ala?Ala?Ala?Gln?Ala?Leu?Gly?Ser?Pro?His?Ile?Lys?Val?Gly?Ala?Gly

105 110 115

gag?ggc?acc?aat?ggt?gtg?gtt?ccc?att?gct?cac?atg?gcc?agt?gcg?ttt 499

Glu?Gly?Thr?Asn?Gly?Val?Val?Pro?Ile?Ala?His?Met?Ala?Ser?Ala?Phe

120 125 130

act?gat?ctc?gct?gcg?gaa?gct?gaa?gct?cat?ggc?gtc?aag?ctc?gcg?ttg 547

Thr?Asp?Leu?Ala?Ala?Glu?Ala?Glu?Ala?His?Gly?Val?Lys?Leu?Ala?Leu

135 140 145

gaa?gca?act?ccg?ttt?tct?cac?ctg?aag?acc?atc?tac?gac?gcg?ctg?gaa 595

Glu?Ala?Thr?Pro?Phe?Ser?His?Leu?Lys?Thr?Ile?Tyr?Asp?Ala?Leu?Glu

150 155 160 165

gtt?gtc?agc?cat?tcc?gat?agc?cca?tcg?gct?gga?ctc?atg?gtt?gat?atc 643

Val?Val?Ser?His?Ser?Asp?Ser?Pro?Ser?Ala?Gly?Leu?Met?Val?Asp?Ile

170 175 180

tgg?cac?acc?gcg?aaa?atc?gga?atc?ccc?aac?gat?gaa?ctg?tgg?cgc?aac 691

Trp?His?Thr?Ala?Lys?Ile?Gly?Ile?Pro?Asn?Asp?Glu?Leu?Trp?Arg?Asn

185 190 195

att?cca?ctg?tcc?aag?gtc?aac?gca?gtg?gag?gtt?gat?gat?ggt?ttc?att 739

Ile?Pro?Leu?Ser?Lys?Val?Asn?Ala?Val?Glu?Val?Asp?Asp?Gly?Phe?Ile

200 205 210

gac?acc?cca?att?gat?ctt?ttc?gat?gac?tcc?acc?aac?cgt?cgc?gcg?tac 787

Asp?Thr?Pro?Ile?Asp?Leu?Phe?Asp?Asp?Ser?Thr?Asn?Arg?Arg?Ala?Tyr

215 220 225

tgc?ggt?gaa?ggc?gaa?ttt?gat?ccc?gca?agc?ttc?atc?cgt?ggc?gcc?atc 835

Cys?Gly?Glu?Gly?Glu?Phe?Asp?Pro?Ala?Ser?Phe?Ile?Arg?Gly?Ala?Ile

230 235 240 245

gac?gcc?ggt?tgg?acg?ggc?gca?tat?ggt?gtg?gaa?att?att?tcc?gca?gag 883

Asp?Ala?Gly?Trp?Thr?Gly?Ala?Tyr?Gly?Val?Glu?Ile?Ile?Ser?Ala?Glu

250 255 260

cac?cga?agc?ctc?ccg?gtg?aaa?gaa?ggg?ctg?caa?cgt?gct?ttc?gac?acc 931

His?Arg?Ser?Leu?Pro?Val?Lys?Glu?Gly?Leu?Gln?Arg?Ala?Phe?Asp?Thr

265 270 275

acc?atc?gca?gcg?ttt?gaa?caa?gct?gct?cgt?ctc?gcc?ccc?tcc?act?aac 979

Thr?Ile?Ala?Ala?Phe?Glu?Gln?Ala?Ala?Arg?Leu?Ala?Pro?Ser?Thr?Asn

280 285 290

tgatctttga?aaggctgaaa?aaa 1002

<210>482

<211>293

<212>PRT

＜213〉Corynebacterium glutamicum

<400>482

Met?Lys?Pro?Gln?Leu?Ile?Ala?Ser?Cys?Trp?Thr?Ser?Ala?Gly?Asp?Ala

1 5 10 15

Ala?Pro?Asp?Arg?Asp?Asp?Leu?Ser?Ser?Pro?Val?Ala?Ile?Asp?Glu?Arg

20 25 30

Ile?Ala?Leu?Val?Ala?Glu?Thr?Gly?Trp?Ala?Gly?Ile?Gly?Leu?Val?His

35 40 45

Ala?Asp?Leu?Ile?Lys?Ala?Arg?Asp?Thr?Ile?Gly?Tyr?Glu?Glu?Leu?Arg

50 55 60

Arg?Arg?Ile?His?Ala?Ala?Gly?Ile?Glu?Ile?Ile?Glu?Val?Glu?Phe?Leu

65 70 75 80

Asn?Gly?Trp?Trp?Ala?Thr?Gly?Ala?Glu?Arg?Gln?Glu?Ser?Asp?Ala?Val

85 90 95

Arg?Ala?Asp?Leu?Phe?Ala?Ala?Ala?Gln?Ala?Leu?Gly?Ser?Pro?His?Ile

100 105 110

Lys?Val?Gly?Ala?Gly?Glu?Gly?Thr?Asn?Gly?Val?Val?Pro?Ile?Ala?His

115 120 125

Met?Ala?Ser?Ala?Phe?Thr?Asp?Leu?Ala?Ala?Glu?Ala?Glu?Ala?His?Gly

130 135 140

Val?Lys?Leu?Ala?Leu?Glu?Ala?Thr?Pro?Phe?Ser?His?Leu?Lys?Thr?Ile

145 150 155 160

Tyr?Asp?Ala?Leu?Glu?Val?Val?Ser?His?Ser?Asp?Ser?Pro?Ser?Ala?Gly

165 170 175

Leu?Met?Val?Asp?Ile?Trp?His?Thr?Ala?Lys?Ile?Gly?Ile?Pro?Asn?Asp

180 185 190

Glu?Leu?Trp?Arg?Asn?Ile?Pro?Leu?Ser?Lys?Val?Asn?Ala?Val?Glu?Val

195 200 205

Asp?Asp?Gly?Phe?Ile?Asp?Thr?Pro?Ile?Asp?Leu?Phe?Asp?Asp?Ser?Thr

210 215 220

Asn?Arg?Arg?Ala?Tyr?Cys?Gly?Glu?Gly?Glu?Phe?Asp?Pro?Ala?Ser?Phe

225 230 235 240

Ile?Arg?Gly?Ala?Ile?Asp?Ala?Gly?Trp?Thr?Gly?Ala?Tyr?Gly?Val?Glu

245 250 255

Ile?Ile?Ser?Ala?Glu?His?Arg?Ser?Leu?Pro?Val?Lys?Glu?Gly?Leu?Gln

260 265 270

Arg?Ala?Phe?Asp?Thr?Thr?Ile?Ala?Ala?Phe?Glu?Gln?Ala?Ala?Arg?Leu

275 280 285

Ala?Pro?Ser?Thr?Asn

290

<210>483

<211>990

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(967)

<223>RXN01593

<400>483

atatgacagc?cttcttcttg?atctagatgg?aaccgtctac?gagggcggcc?gagccattga?60

gcacgtagtt?tctgcgctct?ctggcgccgg?cctacccgtc?atg?tat?gtc?acc?aat 115

Met?Tyr?Val?Thr?Asn

1 5

aat?gcc?tcc?cgt?gct?ccg?gag?gtg?gtg?gct?gcg?caa?ctc?cgt?gag?att 163

Asn?Ala?Ser?Arg?Ala?Pro?Glu?Val?Val?Ala?Ala?Gln?Leu?Arg?Glu?Ile

10 15 20

ggc?ctt?gcc?gac?acc?act?gcg?gac?aat?gtg?atg?aca?tct?gct?caa?gct 211

Gly?Leu?Ala?Asp?Thr?Thr?Ala?Asp?Asn?Val?Met?Thr?Ser?Ala?Gln?Ala

25 30 35

gcc?tgc?aag?atg?gcg?gcg?gag?aag?att?ccc?gct?gga?tcc?aag?gtg?tat 259

Ala?Cys?Lys?Met?Ala?Ala?Glu?Lys?Ile?Pro?Ala?Gly?Ser?Lys?Val?Tyr

40 45 50

gtt?ttg?ggt?tca?gaa?tcc?ttc?cgc?gag?cta?gct?act?gaa?gct?ggt?ttt 307

Val?Leu?Gly?Ser?Glu?Ser?Phe?Arg?Glu?Leu?Ala?Thr?Glu?Ala?Gly?Phe

55 60 65

gtg?gtg?gtt?gat?tcg?gct?gat?gat?aaa?cct?gtg?gct?gtg?ctt?cac?ggc 355

Val?Val?Val?Asp?Ser?Ala?Asp?Asp?Lys?Pro?Val?Ala?Val?Leu?His?Gly

70 75 80 85

cac?aac?cct?gag?acc?ggt?tgg?gct?cag?ttg?agc?gag?gct?gcg?ctg?tca 403

His?Asn?Pro?Glu?Thr?Gly?Trp?Ala?Gln?Leu?Ser?Glu?Ala?Ala?Leu?Ser

90 95 100

att?aat?gct?ggc?gcg?cag?tat?ttt?gca?tca?aat?ttg?gat?tcc?acc?ctt 451

Ile?Asn?Ala?Gly?Ala?Gln?Tyr?Phe?Ala?Ser?Asn?Leu?Asp?Ser?Thr?Leu

105 110 115

ccc?atg?gaa?cgc?ggt?cgt?cac?att?ggc?aac?ggt?tcc?atg?gtg?gct?gcc 499

Pro?Met?Glu?Arg?Gly?Arg?His?Ile?Gly?Asn?Gly?Ser?Met?Val?Ala?Ala

120 125 130

gtg?gtc?aac?gcg?act?ggc?gta?aag?cct?ctt?tcc?gca?ggt?aag?cca?ggc 547

Val?Val?Asn?Ala?Thr?Gly?Val?Lys?Pro?Leu?Ser?Ala?Gly?Lys?Pro?Gly

135 140 145

ccc?gcg?atg?ttc?tat?gcg?ggg?gct?gaa?act?ctt?aat?tct?tca?aag?cct 595

Pro?Ala?Met?Phe?Tyr?Ala?Gly?Ala?Glu?Thr?Leu?Asn?Ser?Ser?Lys?Pro

150 155 160 165

ttg?gct?gtc?ggc?gat?cgt?ctc?gat?acc?gat?atc?gcc?ggc?gga?aac?gct 643

Leu?Ala?Val?Gly?Asp?Arg?Leu?Asp?Thr?Asp?Ile?Ala?Gly?Gly?Asn?Ala

170 175 180

gca?ggc?atg?gac?aca?ttc?cag?gtc?ctg?acc?ggc?gtc?agc?ggc?tac?tac 691

Ala?Gly?Met?Asp?Thr?Phe?Gln?Val?Leu?Thr?Gly?Val?Ser?Gly?Tyr?Tyr

185 190 195

gat?ttg?gtg?cgc?gcc?att?ccc?aga?gca?gcg?ccc?cac?cta?tat?cgc?cac 739

Asp?Leu?Val?Arg?Ala?Ile?Pro?Arg?Ala?Ala?Pro?His?Leu?Tyr?Arg?His

200 205 210

ctc?gat?gca?gga?tct?cta?cag?cga?tcc?ggg?cga?gct?caa?gcc?agg?tgc 787

Leu?Asp?Ala?Gly?Ser?Leu?Gln?Arg?Ser?Gly?Arg?Ala?Gln?Ala?Arg?Cys

215 220 225

cca?ggg?cgg?ttt?ttc?agc?gct?tat?cga?cgg?cga?cac?cct?ggt?cat?ttc 835

Pro?Gly?Arg?Phe?Phe?Ser?Ala?Tyr?Arg?Arg?Arg?His?Pro?Gly?His?Phe

230 235 240 245

cgg?cgg?cga?tgc?cgg?cgc?aac?tcc?ggt?tgc?agc?act?ccg?cac?tgc?gtt 883

Arg?Arg?Arg?Cys?Arg?Arg?Asn?Ser?Gly?Cys?Ser?Thr?Pro?His?Cys?Val

250 255 260

gga?tgt?ggc?ctg?ggc?ggc?cac?aga?gca?gtc?acc?gag?gta?cgc?gct?gat 931

Gly?Cys?Gly?Leu?Gly?Gly?His?Arg?Ala?Val?Thr?Glu?Val?Arg?Ala?Asp

265 270 275

tca?gag?gta?gct?gct?act?gca?ttg?cag?agc?tgg?tgg?taaacggtga 977

Ser?Glu?Val?Ala?Ala?Thr?Ala?Leu?Gln?Ser?Trp?Trp

280 285

attcaccaaa?gcc 990

<210>484

<211>289

<212>PRT

＜213〉Corynebacterium glutamicum

<400>484

Met?Tyr?Val?Thr?Asn?Asn?Ala?Ser?Arg?Ala?Pro?Glu?Val?Val?Ala?Ala

1 5 10 15

Gln?Leu?Arg?Glu?Ile?Gly?Leu?Ala?Asp?Thr?Thr?Ala?Asp?Asn?Val?Met

20 25 30

Thr?Ser?Ala?Gln?Ala?Ala?Cys?Lys?Met?Ala?Ala?Glu?Lys?Ile?Pro?Ala

35 40 45

Gly?Ser?Lys?Val?Tyr?Val?Leu?Gly?Ser?Glu?Ser?Phe?Arg?Glu?Leu?Ala

50 55 60

Thr?Glu?Ala?Gly?Phe?Val?Val?Val?Asp?Ser?Ala?Asp?Asp?Lys?Pro?Val

65 70 75 80

Ala?Val?Leu?His?Gly?His?Asn?Pro?Glu?Thr?Gly?Trp?Ala?Gln?Leu?Ser

85 90 95

Glu?Ala?Ala?Leu?Ser?Ile?Asn?Ala?Gly?Ala?Gln?Tyr?Phe?Ala?Ser?Asn

100 105 110

Leu?Asp?Ser?Thr?Leu?Pro?Met?Glu?Arg?Gly?Arg?His?Ile?Gly?Asn?Gly

115 120 125

Ser?Met?Val?Ala?Ala?Val?Val?Asn?Ala?Thr?Gly?Val?Lys?Pro?Leu?Ser

130 135 140

Ala?Gly?Lys?Pro?Gly?Pro?Ala?Met?Phe?Tyr?Ala?Gly?Ala?Glu?Thr?Leu

145 150 155 160

Asn?Ser?Ser?Lys?Pro?Leu?Ala?Val?Gly?Asp?Arg?Leu?Asp?Thr?Asp?Ile

165 170 175

Ala?Gly?Gly?Asn?Ala?Ala?Gly?Met?Asp?Thr?Phe?Gln?Val?Leu?Thr?Gly

180 185 190

Val?Ser?Gly?Tyr?Tyr?Asp?Leu?Val?Arg?Ala?Ile?Pro?Arg?Ala?Ala?Pro

195 200 205

His?Leu?Tyr?Arg?His?Leu?Asp?Ala?Gly?Ser?Leu?Gln?Arg?Ser?Gly?Arg

210 215 220

Ala?Gln?Ala?Arg?Cys?Pro?Gly?Arg?Phe?Phe?Ser?Ala?Tyr?Arg?Arg?Arg

225 230 235 240

His?Pro?Gly?His?Phe?Arg?Arg?Arg?Cys?Arg?Arg?Asn?Ser?Gly?Cys?Ser

245 250 255

Thr?Pro?His?Cys?Val?Gly?Cys?Gly?Leu?Gly?Gly?His?Arg?Ala?Val?Thr

260 265 270

Glu?Val?Arg?Ala?Asp?Ser?Glu?Val?Ala?Ala?Thr?Ala?Leu?Gln?Ser?Trp

275 280 285

Trp

<210>485

<211>1173

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1150)

<223>RXN00337

<400>485

ggacgcttat?tggtgagcat?tcggattacg?ccggtggtgt?ggtgctggcg?gctaatgcga?60

attgccggac?tgcggctgcc?gtcaataaag?aaccgcgacg?atg?ttg?tta?acg?tat 115

Met?Leu?Leu?Thr?Tyr

1 5

gcg?ttt?gtg?gat?gtg?gag?gga?ggc?gtc?gaa?aag?cat?tct?tta?agc?act 163

Ala?Phe?Val?Asp?Val?Glu?Gly?Gly?Val?Glu?Lys?His?Ser?Leu?Ser?Thr

10 15 20

gcg?gac?att?gca?gct?cgc?gca?cac?gcc?cat?atg?aaa?tcc?cat?gat?gtt 211

Ala?Asp?Ile?Ala?Ala?Arg?Ala?His?Ala?His?Met?Lys?Ser?His?Asp?Val

25 30 35

ttg?ggg?cgg?cag?act?acg?ccg?cct?cag?ccg?gag?ggc?ggc?gtt?gct?gcc 259

Leu?Gly?Arg?Gln?Thr?Thr?Pro?Pro?Gln?Pro?Glu?Gly?Gly?Val?Ala?Ala

40 45 50

cgg?ttg?ggc?ggg?att?gcg?tgg?aca?atg?atc?cat?aag?caa?atg?ctt?tcg 307

Arg?Leu?Gly?Gly?Ile?Ala?Trp?Thr?Met?Ile?His?Lys?Gln?Met?Leu?Ser

55 60 65

cgt?gac?aca?aaa?ggc?ctg?gat?atc?acc?gtg?ttg?agc?acc?att?cct?gag 355

Arg?Asp?Thr?Lys?Gly?Leu?Asp?Ile?Thr?Val?Leu?Ser?Thr?Ile?Pro?Glu

70 75 80 85

ggg?gtg?ggg?ctg?ggt?gaa?aat?tcc?gcc?atg?gat?gtg?gcg?ctc?gca?ttg 403

Gly?Val?Gly?Leu?Gly?Glu?Asn?Ser?Ala?Met?Asp?Val?Ala?Leu?Ala?Leu

90 95 100

gcg?ctg?tat?cgg?gaa?aat?att?gag?gaa?gcc?ccc?acg?aag?gcg?cgc?att 451

Ala?Leu?Tyr?Arg?Glu?Asn?Ile?Glu?Glu?Ala?Pro?Thr?Lys?Ala?Arg?Ile

105 110 115

gcg?gag?att?tgt?tcg?cag?tcc?gca?ttc?atg?ttc?agt?gag?act?tca?gtg 499

Ala?Glu?Ile?Cys?Ser?Gln?Ser?Ala?Phe?Met?Phe?Ser?Glu?Thr?Ser?Val

120 125 130

ttg?cgt?gcg?cgg?cac?acc?gtg?gcg?ttg?cgg?ggt?gaa?act?gga?cag?att 547

Leu?Arg?Ala?Arg?His?Thr?Val?Ala?Leu?Arg?Gly?Glu?Thr?Gly?Gln?Ile

135 140 145

tcg?gtg?gtt?gat?tac?gcc?gat?ggt?tcg?gtc?act?cag?gcg?cca?cat?ccg 595

Ser?Val?Val?Asp?Tyr?Ala?Asp?Gly?Ser?Val?Thr?Gln?Ala?Pro?His?Pro

150 155 160 165

gtg?agt?cgt?tcc?gct?ggt?ttg?tcg?gca?ttt?gtt?gtt?gct?gcg?caa?act 643

Val?Ser?Arg?Ser?Ala?Gly?Leu?Ser?Ala?Phe?Val?Val?Ala?Ala?Gln?Thr

170 175 180

gaa?act?gat?ccg?agc?att?tac?cgc?gag?atc?tat?gct?cga?cat?gcg?ttt 691

Glu?Thr?Asp?Pro?Ser?Ile?Tyr?Arg?Glu?Ile?Tyr?Ala?Arg?His?Ala?Phe

185 190 195

atc?gat?gaa?gct?gcg?cgc?gct?ttc?agt?gtg?gaa?tct?ttg?cgg?ttg?ctt 739

Ile?Asp?Glu?Ala?Ala?Arg?Ala?Phe?Ser?Val?Glu?Ser?Leu?Arg?Leu?Leu

200 205 210

ccc?gac?gct?tcc?act?cgt?gtt?gtg?gat?tgg?ttg?cag?gcc?gtg?att?gag 787

Pro?Asp?Ala?Ser?Thr?Arg?Val?Val?Asp?Trp?Leu?Gln?Ala?Val?Ile?Glu

215 220 225

gtg?act?ggt?cga?gag?gat?ctg?ccc?tcg?att?gaa?caa?gcc?cag?cgc?tgg 835

Val?Thr?Gly?Arg?Glu?Asp?Leu?Pro?Ser?Ile?Glu?Gln?Ala?Gln?Arg?Trp

230 235 240 245

ttg?aat?ctg?tgg?gaa?aac?gaa?acc?cgg?cgc?gct?cag?agg?aca?gcc?aat 883

Leu?Asn?Leu?Trp?Glu?Asn?Glu?Thr?Arg?Arg?Ala?Gln?Arg?Thr?Ala?Asn

250 255 260

gcc?ctg?cgt?tcg?aga?agg?ctg?agt?gag?ttt?tct?gag?ctg?ctg?atg?gaa 931

Ala?Leu?Arg?Ser?Arg?Arg?Leu?Ser?Glu?Phe?Ser?Glu?Leu?Leu?Met?Glu

265 270 275

tcc?caa?gat?gat?ttg?agc?gac?acc?ttc?gat?ttc?ccc?cct?gct?gat?ttg 979

Ser?Gln?Asp?Asp?Leu?Ser?Asp?Thr?Phe?Asp?Phe?Pro?Pro?Ala?Asp?Leu

280 285 290

gcg?ctt?gct?cgt?ttg?tgc?gtc?gag?cgg?ggt?gcc?aca?gct?gct?cgg?tcc 1027

Ala?Leu?Ala?Arg?Leu?Cys?Val?Glu?Arg?Gly?Ala?Thr?Ala?Ala?Arg?Ser

295 300 305

acg?tca?gcg?cgc?ggt?gtg?att?gcg?ttg?gtt?gat?gcc?cat?cat?gcg?cac 1075

Thr?Ser?Ala?Arg?Gly?Val?Ile?Ala?Leu?Val?Asp?Ala?His?His?Ala?His

310 315 320 325

aat?ttt?gct?gcg?gat?ctc?agc?gag?gat?ggc?ttg?ttg?gtg?gtt?cct?ctc 1123

Asn?Phe?Ala?Ala?Asp?Leu?Ser?Glu?Asp?Gly?Leu?Leu?Val?Val?Pro?Leu

330 335 340

ggg?cac?ggg?gac?gtc?gcg?gaa?cag?ggc?tagcacgcct?acttaaccag 1170

Gly?His?Gly?Asp?Val?Ala?Glu?Gln?Gly

345 350

cct 1173

<210>486

<211>350

<212>PRT

＜213〉Corynebacterium glutamicum

<400>486

Met?Leu?Leu?Thr?Tyr?Ala?Phe?Val?Asp?Val?Glu?Gly?Gly?Val?Glu?Lys

1 5 10 15

His?Ser?Leu?Ser?Thr?Ala?Asp?Ile?Ala?Ala?Arg?Ala?His?Ala?His?Met

20 25 30

Lys?Ser?His?Asp?Val?Leu?Gly?Arg?Gln?Thr?Thr?Pro?Pro?Gln?Pro?Glu

35 40 45

Gly?Gly?Val?Ala?Ala?Arg?Leu?Gly?Gly?Ile?Ala?Trp?Thr?Met?Ile?His

50 55 60

Lys?Gln?Met?Leu?Ser?Arg?Asp?Thr?Lys?Gly?Leu?Asp?Ile?Thr?Val?Leu

65 70 75 80

Ser?Thr?Ile?Pro?Glu?Gly?Val?Gly?Leu?Gly?Glu?Asn?Ser?Ala?Met?Asp

85 90 95

Val?Ala?Leu?Ala?Leu?Ala?Leu?Tyr?Arg?Glu?Asn?Ile?Glu?Glu?Ala?Pro

100 105 110

Thr?Lys?Ala?Arg?Ile?Ala?Glu?Ile?Cys?Ser?Gln?Ser?Ala?Phe?Met?Phe

115 120 125

Ser?Glu?Thr?Ser?Val?Leu?Arg?Ala?Arg?His?Thr?Val?Ala?Leu?Arg?Gly

130 135 140

Glu?Thr?Gly?Gln?Ile?Ser?Val?Val?Asp?Tyr?Ala?Asp?Gly?Ser?Val?Thr

145 150 155 160

Gln?Ala?Pro?His?Pro?Val?Ser?Arg?Ser?Ala?Gly?Leu?Ser?Ala?Phe?Val

165 170 175

Val?Ala?Ala?Gln?Thr?Glu?Thr?Asp?Pro?Ser?Ile?Tyr?Arg?Glu?Ile?Tyr

180 185 190

Ala?Arg?His?Ala?Phe?Ile?Asp?Glu?Ala?Ala?Arg?Ala?Phe?Ser?Val?Glu

195 200 205

Ser?Leu?Arg?Leu?Leu?Pro?Asp?Ala?Ser?Thr?Arg?Val?Val?Asp?Trp?Leu

210 215 220

Gln?Ala?Val?Ile?Glu?Val?Thr?Gly?Arg?Glu?Asp?Leu?Pro?Ser?Ile?Glu

225 230 235 240

Gln?Ala?Gln?Arg?Trp?Leu?Asn?Leu?Trp?Glu?Asn?Glu?Thr?Arg?Arg?Ala

245 250 255

Gln?Arg?Thr?Ala?Asn?Ala?Leu?Arg?Ser?Arg?Arg?Leu?Ser?Glu?Phe?Ser

260 265 270

Glu?Leu?Leu?Met?Glu?Ser?Gln?Asp?Asp?Leu?Ser?Asp?Thr?Phe?Asp?Phe

275 280 285

Pro?Pro?Ala?Asp?Leu?Ala?Leu?Ala?Arg?Leu?Cys?Val?Glu?Arg?Gly?Ala

290 295 300

Thr?Ala?Ala?Arg?Ser?Thr?Ser?Ala?Arg?Gly?Val?Ile?Ala?Leu?Val?Asp

305 310 315 320

Ala?His?His?Ala?His?Asn?Phe?Ala?Ala?Asp?Leu?Ser?Glu?Asp?Gly?Leu

325 330 335

Leu?Val?Val?Pro?Leu?Gly?His?Gly?Asp?Val?Ala?Glu?Gln?Gly

340 345 350

<210>487

<211>1248

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1225)

<223>RXS00584

<400>487

tagttgtgcc?acctaaaacg?cgaacagaac?cggagtcgag?cagcacctcc?ccgcaagggt?60

agaggggctg?cttttttgtt?tcctaaattc?accccatccc?atg?cat?agc?cct?gaa 115

Met?His?Ser?Pro?Glu

1 5

agg?caa?gaa?aaa?atg?agt?tct?cca?gtc?tca?ctc?gaa?aac?gcg?gcg?tca 163

Arg?Gln?Glu?Lys?Met?Ser?Ser?Pro?Val?Ser?Leu?Glu?Asn?Ala?Ala?Ser

10 15 20

acc?agc?aac?aag?cgc?gtc?gtg?gct?ttc?cac?gag?ctg?cct?agc?cct?aca 211

Thr?Ser?Asn?Lys?Arg?Val?Val?Ala?Phe?His?Glu?Leu?Pro?Ser?Pro?Thr

25 30 35

gat?ctc?atc?gcc?gca?aac?cca?ctg?aca?cca?aag?cag?gct?tcc?aag?gtg 259

Asp?Leu?Ile?Ala?Ala?Asn?Pro?Leu?Thr?Pro?Lys?Gln?Ala?Ser?Lys?Val

40 45 50

gag?cag?gat?cgc?cag?gac?atc?gct?gat?atc?ttc?gct?ggc?gac?gat?gac 307

Glu?Gln?Asp?Arg?Gln?Asp?Ile?Ala?Asp?Ile?Phe?Ala?Gly?Asp?Asp?Asp

55 60 65

cgc?ctc?gtt?gtc?gtt?gtg?gga?cct?tgc?tca?gtt?cac?gat?cct?gaa?gca 355

Arg?Leu?Val?Val?Val?Val?Gly?Pro?Cys?Ser?Val?His?Asp?Pro?Glu?Ala

70 75 80 85

gcc?atc?gat?tac?gca?aac?cgc?ctg?gct?ccg?ctg?gca?aag?cgc?ctt?gat 403

Ala?Ile?Asp?Tyr?Ala?Asn?Arg?Leu?Ala?Pro?Leu?Ala?Lys?Arg?Leu?Asp

90 95 100

cag?gac?ctc?aag?att?gtc?atg?cgc?gtg?tacttc?gag?aag?cct?cgc?acc 451

Gln?Asp?Leu?Lys?Ile?Val?Met?Arg?Val?Tyr?Phe?Glu?Lys?Pro?Arg?Thr

105 110 115

atc?gtc?gga?tgg?aag?gga?ttg?atc?aat?gat?cct?cac?ctc?aac?gaa?acc 499

Ile?Val?Gly?Trp?Lys?Gly?Leu?Ile?Asn?Asp?Pro?His?Leu?Asn?Glu?Thr

120 125 130

tac?gac?atc?cca?gag?ggc?ttg?cgc?att?gcg?cgc?aaa?gtg?ctt?atc?gac 547

Tyr?Asp?Ile?Pro?Glu?Gly?Leu?Arg?Ile?Ala?Arg?Lys?Val?Leu?Ile?Asp

135 140 145

gtt?gtg?aac?ctt?gat?ctc?cca?gtc?ggc?tgc?gaa?ttc?ctc?gaa?cca?aac 595

Val?Val?Asn?Leu?Asp?Leu?Pro?Val?Gly?Cys?Glu?Phe?Leu?Glu?Pro?Asn

150 155 160 165

agc?cct?cag?tac?tac?gcc?gac?act?gtc?gca?tgg?gga?gca?atc?ggc?gct 643

Ser?Pro?Gln?Tyr?Tyr?Ala?Asp?Thr?Val?Ala?Trp?Gly?Ala?Ile?Gly?Ala

170 175 180

cgt?acc?acc?gaa?tct?cag?gtg?cac?cgc?cag?ctg?gct?tct?ggg?atg?tct 691

Arg?Thr?Thr?Glu?Ser?Gln?Val?His?Arg?Gln?Leu?Ala?Ser?Gly?Met?Ser

185 190 195

atg?cca?att?ggt?ttc?aag?aac?gga?act?gac?gga?aac?atc?cag?gtt?gca 739

Met?Pro?Ile?Gly?Phe?Lys?Asn?Gly?Thr?Asp?Gly?Asn?Ile?Gln?Val?Ala

200 205 210

gtc?gac?gcg?gta?cag?gct?gcc?cag?aac?cca?cac?ttc?ttc?ttc?gga?acc 787

Val?Asp?Ala?Val?Gln?Ala?Ala?Gln?Asn?Pro?His?Phe?Phe?Phe?Gly?Thr

215 220 225

tcc?gac?gac?ggc?gcg?ctg?agc?gtc?gtg?gag?acc?gca?ggc?aac?agc?aac 835

Ser?Asp?Asp?Gly?Ala?Leu?Ser?Val?Val?Glu?Thr?Ala?Gly?Asn?Ser?Asn

230 235 240 245

tcc?cac?atc?att?ttg?cgc?ggc?ggt?acc?tcc?ggc?ccg?aat?cat?gat?gca 883

Ser?His?Ile?Ile?Leu?Arg?Gly?Gly?Thr?Ser?Gly?Pro?Asn?His?Asp?Ala

250 255 260

gct?tcg?gtg?gag?gcc?gtc?gtc?gag?aag?ctt?ggt?gaa?aac?gct?cgt?ctc 931

Ala?Ser?Val?Glu?Ala?Val?Val?Glu?Lys?Leu?Gly?Glu?Asn?Ala?Arg?Leu

265 270 275

atg?atc?gat?gct?tcc?cat?gct?aac?tcc?ggc?aag?gat?cat?atc?cga?cag 979

Met?Ile?Asp?Ala?Ser?His?Ala?Asn?Ser?Gly?Lys?Asp?His?Ile?Arg?Gln

280 285 290

gtt?gag?gtt?gtt?cgt?gaa?atc?gca?gag?cag?att?tct?ggc?ggt?tct?gaa 1027

Val?Glu?Val?Val?Arg?Glu?Ile?Ala?Glu?Gln?Ile?Ser?Gly?Gly?Ser?Glu

295 300 305

gct?gtg?gct?gga?atc?atg?att?gag?tcc?ttc?ctc?gtt?ggt?ggc?gca?cag 1075

Ala?Val?Ala?Gly?Ile?Met?Ile?Glu?Ser?Phe?Leu?Val?Gly?Gly?Ala?Gln

310 315 320 325

aac?ctt?gat?cct?gcg?aaa?ttg?cgc?atc?aat?ggc?ggt?gaa?ggc?ctg?gtg 1123

Asn?Leu?Asp?Pro?Ala?Lys?Leu?Arg?Ile?Asn?Gly?Gly?Glu?Gly?Leu?Val

330 335 340

tac?gga?cag?tct?gtg?acc?gat?aag?tgc?atc?gat?att?gac?acc?acc?atc 1171

Tyr?Gly?Gln?Ser?Val?Thr?Asp?Lys?Cys?Ile?Asp?Ile?Asp?Thr?Thr?Ile

345 350 355

gat?ttg?ctc?gct?gag?ctg?gcc?gca?gca?gta?agg?gaa?cgc?cga?gca?gca 1219

Asp?Leu?Leu?Ala?Glu?Leu?Ala?Ala?Ala?Val?Arg?Glu?Arg?Arg?Ala?Ala

360 365 370

gcc?aag?taattaaggg?cgctagactg?tta 1248

Ala?Lys

375

<210>488

<211>375

<212>PRT

＜213〉Corynebacterium glutamicum

<400>488

Met?His?Ser?Pro?Glu?Arg?Gln?Glu?Lys?Met?Ser?Ser?Pro?Val?Ser?Leu

1 5 10 15

Glu?Asn?Ala?Ala?Ser?Thr?Ser?Asn?Lys?Arg?Val?Val?Ala?Phe?His?Glu

20 25 30

Leu?Pro?Ser?Pro?Thr?Asp?Leu?Ile?Ala?Ala?Asn?Pro?Leu?Thr?Pro?Lys

35 40 45

Gln?Ala?Ser?Lys?Val?Glu?Gln?Asp?Arg?Gln?Asp?Ile?Ala?Asp?Ile?Phe

50 55 60

Ala?Gly?Asp?Asp?Asp?Arg?Leu?Val?Val?Val?Val?Gly?Pro?Cys?Ser?Val

65 70 75 80

His?Asp?Pro?Glu?Ala?Ala?Ile?Asp?Tyr?Ala?Asn?Arg?Leu?Ala?Pro?Leu

85 90 95

Ala?Lys?Arg?Leu?Asp?Gln?Asp?Leu?Lys?Ile?Val?Met?Arg?Val?Tyr?Phe

100 105 110

Glu?Lys?Pro?Arg?Thr?Ile?Val?Gly?Trp?Lys?Gly?Leu?Ile?Asn?Asp?Pro

115 120 125

His?Leu?Asn?Glu?Thr?Tyr?Asp?Ile?Pro?Glu?Gly?Leu?Arg?Ile?Ala?Arg

130 135 140

Lys?Val?Leu?Ile?Asp?Val?Val?Asn?Leu?Asp?Leu?Pro?Val?Gly?Cys?Glu

145 150 155 160

Phe?Leu?Glu?Pro?Asn?Ser?Pro?Gln?Tyr?Tyr?Ala?Asp?Thr?Val?Ala?Trp

165 170 175

Gly?Ala?Ile?Gly?Ala?Arg?Thr?Thr?Glu?Ser?Gln?Val?His?Arg?Gln?Leu

180 185 190

Ala?Ser?Gly?Met?Ser?Met?Pro?Ile?Gly?Phe?Lys?Asn?Gly?Thr?Asp?Gly

195 200 205

Asn?Ile?Gln?Val?Ala?Val?Asp?Ala?Val?Gln?Ala?Ala?Gln?Asn?Pro?His

210 215 220

Phe?Phe?Phe?Gly?Thr?Ser?Asp?Asp?Gly?Ala?Leu?Ser?Val?Val?Glu?Thr

225 230 235 240

Ala?Gly?Asn?Ser?Asn?Ser?His?Ile?Ile?Leu?Arg?Gly?Gly?Thr?Ser?Gly

245 250 255

Pro?Asn?His?Asp?Ala?Ala?Ser?Val?Glu?Ala?Val?Val?Glu?Lys?Leu?Gly

260 265 270

Glu?Asn?Ala?Arg?Leu?Met?Ile?Asp?Ala?Ser?His?Ala?Asn?Ser?Gly?Lys

275 280 285

Asp?His?Ile?Arg?Gln?Val?Glu?Val?Val?Arg?Glu?Ile?Ala?Glu?Gln?Ile

290 295 300

Ser?Gly?Gly?Ser?Glu?Ala?Val?Ala?Gly?Ile?Met?Ile?Glu?Ser?Phe?Leu

305 310 315 320

Val?Gly?Gly?Ala?Gln?Asn?Leu?Asp?Pro?Ala?Lys?Leu?Arg?Ile?Asn?Gly

325 330 335

Gly?Glu?Gly?Leu?Val?Tyr?Gly?Gln?Ser?Val?Thr?Asp?Lys?Cys?Ile?Asp

340 345 350

Ile?Asp?Thr?Thr?Ile?Asp?Leu?Leu?Ala?Glu?Leu?Ala?Ala?Ala?Val?Arg

355 360 365

Glu?Arg?Arg?Ala?Ala?Ala?Lys

370 375

<210>489

<211>1131

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1108)

<223>RXS02574

<400>489

tgtgctcctt?gcgggctgcg?cagaagagcc?ggaacagcaa?aaagcaataa?gccgcttatc?60

gacgtccccc?tccacccctc?ccgcaccgac?cgcggaggat?ttg?gcg?cgc?gcg?caa 115

Leu?Ala?Arg?Ala?Gln

1 5

atc?cct?gaa?cag?caa?cgc?gac?caa?gtc?gcg?tcg?ctg?atg?atg?gtt?gga 163

Ile?Pro?Glu?Gln?Gln?Arg?Asp?Gln?Val?Ala?Ser?Leu?Met?Met?Val?Gly

10 15 20

gtt?gcg?aat?tat?gat?cag?gca?ttg?gat?gcg?ctc?aat?cag?ggg?gtg?ggt 211

Val?Ala?Asn?Tyr?Asp?Gln?Ala?Leu?Asp?Ala?Leu?Asn?Gln?Gly?Val?Gly

25 30 35

ggc?atc?ttt?att?ggt?tcc?tgg?aca?gat?gaa?aat?ctg?ctc?acg?gaa?cct 259

Gly?Ile?Phe?Ile?Gly?Ser?Trp?Thr?Asp?Glu?Asn?Leu?Leu?Thr?Glu?Pro

40 45 50

ggc?cgt?aat?att?gag?gcg?ctc?cgc?gaa?gcc?gtc?ggc?agg?gat?ttc?tcc 307

Gly?Arg?Asn?Ile?Glu?Ala?Leu?Arg?Glu?Ala?Val?Gly?Arg?Asp?Phe?Ser

55 60 65

gtc?agc?atc?gac?ttc?gaa?ggc?ggc?cgc?gtc?cag?cgt?gcc?acc?aat?att 355

Val?Ser?Ile?Asp?Phe?Glu?Gly?Gly?Arg?Val?Gln?Arg?Ala?Thr?Asn?Ile

70 75 80 85

ctt?ggt?gat?ttc?ccc?tca?ccg?cgc?gtg?atg?gcg?caa?acc?atg?acg?ccg 403

Leu?Gly?Asp?Phe?Pro?Ser?Pro?Arg?Val?Met?Ala?Gln?Thr?Met?Thr?Pro

90 95 100

gaa?caa?gta?gaa?gat?ctc?gca?gaa?atc?cta?ggc?act?ggt?tta?gct?gca 451

Glu?Gln?Val?Glu?Asp?Leu?Ala?Glu?Ile?Leu?Gly?Thr?Gly?Leu?Ala?Ala

105 110 115

cat?ggt?gtg?aca?gtt?aac?ttt?gca?cct?gtt?gta?gat?gta?gat?gct?tgg 499

His?Gly?Val?Thr?Val?Asn?Phe?Ala?Pro?Val?Val?Asp?Val?Asp?Ala?Trp

120 125 130

ggt?ctc?ccc?gtc?gtt?ggc?gat?cgt?tcc?ttt?tcc?aac?gac?cca?gcc?gta 547

Gly?Leu?Pro?Val?Val?Gly?Asp?Arg?Ser?Phe?Ser?Asn?Asp?Pro?Ala?Val

135 140 145

gca?gct?act?tat?gcc?aca?gct?ttt?gca?aag?ggc?tta?agc?aaa?gta?gga 595

Ala?Ala?Thr?Tyr?Ala?Thr?Ala?Phe?Ala?Lys?Gly?Leu?Ser?Lys?Val?Gly

150 155 160 165

att?acc?cca?gta?ttc?aaa?cat?ttc?cca?ggt?cac?ggt?cgt?gca?agt?ggc 643

Ile?Thr?Pro?Val?Phe?Lys?His?Phe?Pro?Gly?His?Gly?Arg?Ala?Ser?Gly

170 175 180

gat?tcg?cac?acc?caa?gat?gtg?gtg?acc?ccc?gca?ctt?gat?gag?ctt?aaa 691

Asp?Ser?His?Thr?Gln?Asp?Val?Val?Thr?Pro?Ala?Leu?Asp?Glu?Leu?Lys

185 190 195

act?tac?gac?ctc?atc?cct?tat?ggt?caa?gca?ctt?tct?gaa?act?gac?gga 739

Thr?Tyr?Asp?Leu?Ile?Pro?Tyr?Gly?Gln?Ala?Leu?Ser?Glu?Thr?Asp?Gly

200 205 210

gcc?gtc?atg?gtg?ggc?cac?atg?att?gtt?cca?ggt?ctt?ggc?acc?gac?gga 787

Ala?Val?Met?Val?Gly?His?Met?Ile?Val?Pro?Gly?Leu?Gly?Thr?Asp?Gly

215 220 225

gtt?cca?tcc?tct?atc?gac?ccc?gcc?acc?tat?caa?ctg?ctc?cgc?agt?ggc 835

Val?Pro?Ser?Ser?Ile?Asp?Pro?Ala?Thr?Tyr?Gln?Leu?Leu?Arg?Ser?Gly

230 235 240 245

gat?tac?cca?ggt?ggc?gtg?cct?ttc?gat?ggc?gtg?atc?tac?acc?gac?gat 883

Asp?Tyr?Pro?Gly?Gly?Val?Pro?Phe?Asp?Gly?Val?Ile?Tyr?Thr?Asp?Asp

250 255 260

ctc?tct?gga?atg?agt?gcc?att?tcc?gcc?acc?cat?tca?ccc?gca?gaa?gca 931

Leu?Ser?Gly?Met?Ser?Ala?Ile?Ser?Ala?Thr?His?Ser?Pro?Ala?Glu?Ala

265 270 275

gtg?ctt?gcc?tcc?ctc?aaa?gca?ggc?gca?gac?caa?gca?cta?tgg?atc?gac 979

Val?Leu?Ala?Ser?Leu?Lys?Ala?Gly?Ala?Asp?Gln?Ala?Leu?Trp?Ile?Asp

280 285 290

tat?ggg?tcg?ttg?ggc?tcc?gcg?att?gat?cgc?gtt?gat?gct?gcc?gtt?agc 1027

Tyr?Gly?Ser?Leu?Gly?Ser?Ala?Ile?Asp?Arg?Val?Asp?Ala?Ala?Val?Ser

295 300 305

agc?ggt?gaa?tac?cct?caa?gaa?caa?atg?ctg?gca?tct?gcg?tta?aga?gtc 1075

Ser?Gly?Glu?Tyr?Pro?Gln?Glu?Gln?Met?Leu?Ala?Ser?Ala?Leu?Arg?Val

310 315 320 325

caa?ttg?ctc?tac?atc?aca?cgt?ctc?gaa?caa?aag?tgaagttacc?agtccgtaac?1128

Gln?Leu?Leu?Tyr?Ile?Thr?Arg?Leu?Glu?Gln?Lys

330 335

ccc 1131

<210>490

<211>336

<212>PRT

＜213〉Corynebacterium glutamicum

<400>490

Leu?Ala?Arg?Ala?Gln?Ile?Pro?Glu?Gln?Gln?Arg?Asp?Gln?Val?Ala?Ser

1 5 10 15

Leu?Met?Met?Val?Gly?Val?Ala?Asn?Tyr?Asp?Gln?Ala?Leu?Asp?Ala?Leu

20 25 30

Asn?Gln?Gly?Val?Gly?Gly?Ile?Phe?Ile?Gly?Ser?Trp?Thr?Asp?Glu?Asn

35 40 45

Leu?Leu?Thr?Glu?Pro?Gly?Arg?Asn?Ile?Glu?Ala?Leu?Arg?Glu?Ala?Val

50 55 60

Gly?Arg?Asp?Phe?Ser?Val?Ser?Ile?Asp?Phe?Glu?Gly?Gly?Arg?Val?Gln

65 70 75 80

Arg?Ala?Thr?Asn?Ile?Leu?Gly?Asp?Phe?Pro?Ser?Pro?Arg?Val?Met?Ala

85 90 95

Gln?Thr?Met?Thr?Pro?Glu?Gln?Val?Glu?Asp?Leu?Ala?Glu?Ile?Leu?Gly

100 105 110

Thr?Gly?Leu?Ala?Ala?His?Gly?Val?Thr?Val?Asn?Phe?Ala?Pro?Val?Val

115 120 125

Asp?Val?Asp?Ala?Trp?Gly?Leu?Pro?Val?Val?Gly?Asp?Arg?Ser?Phe?Ser

130 135 140

Asn?Asp?Pro?Ala?Val?Ala?Ala?Thr?Tyr?Ala?Thr?Ala?Phe?Ala?Lys?Gly

145 150 155 160

Leu?Ser?Lys?Val?Gly?Ile?Thr?Pro?Val?Phe?Lys?His?Phe?Pro?Gly?His

165 170 175

Gly?Arg?Ala?Ser?Gly?Asp?Ser?His?Thr?Gln?Asp?Val?Val?Thr?Pro?Ala

180 185 190

Leu?Asp?Glu?Leu?Lys?Thr?Tyr?Asp?Leu?Ile?Pro?Tyr?Gly?Gln?Ala?Leu

195 200 205

Ser?Glu?Thr?Asp?Gly?Ala?Val?Met?Val?Gly?His?Met?Ile?Val?Pro?Gly

210 215 220

Leu?Gly?Thr?Asp?Gly?Val?Pro?Ser?Ser?Ile?Asp?Pro?Ala?Thr?Tyr?Gln

225 230 235 240

Leu?Leu?Arg?Ser?Gly?Asp?Tyr?Pro?Gly?Gly?Val?Pro?Phe?Asp?Gly?Val

245 250 255

Ile?Tyr?Thr?Asp?Asp?Leu?Ser?Gly?Met?Ser?Ala?Ile?Ser?Ala?Thr?His

260 265 270

Ser?Pro?Ala?Glu?Ala?Val?Leu?Ala?Ser?Leu?Lys?Ala?Gly?Ala?Asp?Gln

275 280 285

Ala?Leu?Trp?Ile?Asp?Tyr?Gly?Ser?Leu?Gly?Ser?Ala?Ile?Asp?Arg?Val

290 295 300

Asp?Ala?Ala?Val?Ser?Ser?Gly?Glu?Tyr?Pro?Gln?Glu?Gln?Met?Leu?Ala

305 310 315 320

Ser?Ala?Leu?Arg?Val?Gln?Leu?Leu?Tyr?Ile?Thr?Arg?Leu?Glu?Gln?Lys

325 330 335

<210>491

<211>1038

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(1008)

<223>RXS03215

<400>491

atc?gat?gtt?gtc?agc?gtc?gtg?gtg?gct?aac?ttc?ctg?cac?cgc?gaa?atc 48

Ile?Asp?Val?Val?Ser?Val?Val?Val?Ala?Asn?Phe?Leu?His?Arg?Glu?Ile

1 5 10 15

gtg?gaa?gca?ctt?ctg?gca?tcc?ggc?aag?cat?gtg?ctg?tgc?gag?aag?cca 96

Val?Glu?Ala?Leu?Leu?Ala?Ser?Gly?Lys?His?Val?Leu?Cys?Glu?Lys?Pro

20 25 30

ctg?tca?gac?acc?atc?gaa?gat?gca?gaa?gcc?atg?att?gag?gca?gcc?ggc 144

Leu?Ser?Asp?Thr?Ile?Glu?Asp?Ala?Glu?Ala?Met?Ile?Glu?Ala?Ala?Gly

35 40 45

cgt?gca?gca?aca?aat?ggc?acc?atc?gcc?cgc?atc?gga?ctg?acc?tac?cgc 192

Arg?Ala?Ala?Thr?Asn?Gly?Thr?Ile?Ala?Arg?Ile?Gly?Leu?Thr?Tyr?Arg

50 55 60

cgt?tcc?cca?ggc?gtg?gca?cac?atc?cgt?gat?ctc?gtg?cag?tcc?ggc?gag 240

Arg?Ser?Pro?Gly?Val?Ala?His?Ile?Arg?Asp?Leu?Val?Gln?Ser?Gly?Glu

65 70 75 80

ctt?ggc?aag?gtt?cta?cac?gtc?acc?ggc?cac?tac?tgg?acc?gac?tac?gga 288

Leu?Gly?Lys?Val?Leu?His?Val?Thr?Gly?His?Tyr?Trp?Thr?Asp?Tyr?Gly

85 90 95

tcc?aat?gca?cag?gca?cca?atc?agc?tgg?cgt?tac?aag?ggg?cca?aac?ggc 336

Ser?Asn?Ala?Gln?Ala?Pro?Ile?Ser?Trp?Arg?Tyr?Lys?Gly?Pro?Asn?Gly

100 105 110

tcc?ggc?gca?ctg?gca?gat?gtg?gga?agc?cac?ctc?acc?tac?ctg?gca?gaa 384

Ser?Gly?Ala?Leu?Ala?Asp?Val?Gly?Ser?His?Leu?Thr?Tyr?Leu?Ala?Glu

115 120 125

ttc?gtt?gca?gga?tct?gac?ttc?gcc?gcc?gtc?cgt?ggt?ggc?cag?ttg?tcc 432

Phe?Val?Ala?Gly?Ser?Asp?Phe?Ala?Ala?Val?Arg?Gly?Gly?Gln?Leu?Ser

130 135 140

acc?gtg?atc?acc?gag?cgc?ccc?aag?cca?ctc?ggc?gcg?att?gtc?ggc?cac 480

Thr?Val?Ile?Thr?Glu?Arg?Pro?Lys?Pro?Leu?Gly?Ala?Ile?Val?Gly?His

145 150 155 160

gaa?ggc?ggc?gca?gtt?tcc?gat?gaa?tac?gaa?gca?gtg?gaa?aat?gat?gac 528

Glu?Gly?Gly?Ala?Val?Ser?Asp?Glu?Tyr?Glu?Ala?Val?Glu?Asn?Asp?Asp

165 170 175

att?gca?tca?ttc?tcc?gga?tcc?ttc?atc?ggt?ggc?gga?acc?gca?acc?ctc 576

Ile?Ala?Ser?Phe?Ser?Gly?Ser?Phe?Ile?Gly?Gly?Gly?Thr?Ala?Thr?Leu

180 185 190

cag?gtc?agc?cgc?att?tcc?cag?gga?cac?cca?aac?acc?cta?ggt?ttt?gaa 624

Gln?Val?Ser?Arg?Ile?Ser?Gln?Gly?His?Pro?Asn?Thr?Leu?Gly?Phe?Glu

195 200 205

gtg?ttc?tgt?gaa?aag?ggc?tcc?gtg?ctc?ttt?gat?ttc?cgc?aac?tca?ggc 672

Val?Phe?Cys?Glu?Lys?Gly?Ser?Val?Leu?Phe?Asp?Phe?Arg?Asn?Ser?Gly

210 215 220

gaa?ttc?aaa?atc?ttc?acc?cca?gca?acc?tcc?ggt?gac?atc?agc?caa?gaa 720

Glu?Phe?Lys?Ile?Phe?Thr?Pro?Ala?Thr?Ser?Gly?Asp?Ile?Ser?Gln?Glu

225 230 235 240

gcc?ggc?tac?cgc?acc?atc?acc?atc?gga?cca?aag?cac?cca?tac?tgg?cgc 768

Ala?Gly?Tyr?Arg?Thr?Ile?Thr?Ile?Gly?Pro?Lys?His?Pro?Tyr?Trp?Arg

245 250 255

ggc?ggc?ctt?gca?atg?gat?gca?cca?ggc?gtg?gga?att?ggc?caa?aac?gaa 816

Gly?Gly?Leu?Ala?Met?Asp?Ala?Pro?Gly?Val?Gly?Ile?Gly?Gln?Asn?Glu

260 265 270

ggc?ttc?gtt?ttc?cag?gcg?cgc?gca?ttc?ctc?gaa?gaa?atc?gca?gga?atc 864

Gly?Phe?Val?Phe?Gln?Ala?Arg?Ala?Phe?Leu?Glu?Glu?Ile?Ala?Gly?Ile

275 280 285

tcc?gaa?gct?gaa?agc?ctg?cca?cgc?tgc?gca?act?ttg?gaa?gaa?ggg?cta 912

Ser?Glu?Ala?Glu?Ser?Leu?Pro?Arg?Cys?Ala?Thr?Leu?Glu?Glu?Gly?Leu

290 295 300

cac?aat?atg?cag?ctc?att?gat?gct?gta?tca?cag?tca?gct?gca?gca?ggt 960

His?Asn?Met?Gln?Leu?Ile?Asp?Ala?Val?Ser?Gln?Ser?Ala?Ala?Ala?Gly

305 310 315 320

ggc?gaa?acc?gtt?gcg?gtc?cca?gcg?gct?gct?ctg?atc?cct?gca?aac?aac 1008

Gly?Glu?Thr?Val?Ala?Val?Pro?Ala?Ala?Ala?Leu?Ile?Pro?Ala?Asn?Asn

325 330 335

tagaaactat?tcagaaagca?tcaccatgaa 1038

<210>492

<211>336

<212>PRT

＜213〉Corynebacterium glutamicum

<400>492

Ile?Asp?Val?Val?Ser?Val?Val?Val?Ala?Asn?Phe?Leu?His?Arg?Glu?Ile

1 5 10 15

Val?Glu?Ala?Leu?Leu?Ala?Ser?Gly?Lys?His?Val?Leu?Cys?Glu?Lys?Pro

20 25 30

Leu?Ser?Asp?Thr?Ile?Glu?Asp?Ala?Glu?Ala?Met?Ile?Glu?Ala?Ala?Gly

35 40 45

Arg?Ala?Ala?Thr?Asn?Gly?Thr?Ile?Ala?Arg?Ile?Gly?Leu?Thr?Tyr?Arg

50 55 60

Arg?Ser?Pro?Gly?Val?Ala?His?Ile?Arg?Asp?Leu?Val?Gln?Ser?Gly?Glu

65 70 75 80

Leu?Gly?Lys?Val?Leu?His?Val?Thr?Gly?His?Tyr?Trp?Thr?Asp?Tyr?Gly

85 90 95

Ser?Asn?Ala?Gln?Ala?Pro?Ile?Ser?Trp?Arg?Tyr?Lys?Gly?Pro?Asn?Gly

100 105 110

Ser?Gly?Ala?Leu?Ala?Asp?Val?Gly?Ser?His?Leu?Thr?Tyr?Leu?Ala?Glu

115 120 125

Phe?Val?Ala?Gly?Ser?Asp?Phe?Ala?Ala?Val?Arg?Gly?Gly?Gln?Leu?Ser

130 135 140

Thr?Val?Ile?Thr?Glu?Arg?Pro?Lys?Pro?Leu?Gly?Ala?Ile?Val?Gly?His

145 150 155 160

Glu?Gly?Gly?Ala?Val?Ser?Asp?Glu?Tyr?Glu?Ala?Val?Glu?Asn?Asp?Asp

165 170 175

Ile?Ala?Ser?Phe?Ser?Gly?Ser?Phe?Ile?Gly?Gly?Gly?Thr?Ala?Thr?Leu

180 185 190

Gln?Val?Ser?Arg?Ile?Ser?Gln?Gly?His?Pro?Asn?Thr?Leu?Gly?Phe?Glu

195 200 205

Val?Phe?Cys?Glu?Lys?Gly?Ser?Val?Leu?Phe?Asp?Phe?Arg?Asn?Ser?Gly

210 215 220

Glu?Phe?Lys?Ile?Phe?Thr?Pro?Ala?Thr?Ser?Gly?Asp?Ile?Ser?Gln?Glu

225 230 235 240

Ala?Gly?Tyr?Arg?Thr?Ile?Thr?Ile?Gly?Pro?Lys?His?Pro?Tyr?Trp?Arg

245 250 255

Gly?Gly?Leu?Ala?Met?Asp?Ala?Pro?Gly?Val?Gly?Ile?Gly?Gln?Asn?Glu

260 265 270

Gly?Phe?Val?Phe?Gln?Ala?Arg?Ala?Phe?Leu?Glu?Glu?Ile?Ala?Gly?Ile

275 280 285

Ser?Glu?Ala?Glu?Ser?Leu?Pro?Arg?Cys?Ala?Thr?Leu?Glu?Glu?Gly?Leu

290 295 300

His?Asn?Met?Gln?Leu?Ile?Asp?Ala?Val?Ser?Gln?Ser?Ala?Ala?Ala?Gly

305 310 315 320

Gly?Glu?Thr?Val?Ala?Val?Pro?Ala?Ala?Ala?Leu?Ile?Pro?Ala?Asn?Asn

325 330 335

<210>493

<211>1031

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(1008)

<223>FRXA01915

<400>493

atc?gat?gtt?gtc?agc?gtc?gtg?gtg?gct?aac?ttc?ctg?cac?cgc?gaa?atc 48

Ile?Asp?Val?Val?Ser?Val?Val?Val?Ala?Asn?Phe?Leu?His?Arg?Glu?Ile

1 5 10 15

gtg?gaa?gca?ctt?ctg?gca?tcc?ggc?aag?cat?gtg?ctg?tgc?gag?aag?cca 96

Val?Glu?Ala?Leu?Leu?Ala?Ser?Gly?Lys?His?Val?Leu?Cys?Glu?Lys?Pro

20 25 30

ctg?tca?gac?acc?atc?gaa?gat?gca?gaa?gcc?atg?att?gag?gca?gcc?ggc 144

Leu?Ser?Asp?Thr?Ile?Glu?Asp?Ala?Glu?Ala?Met?Ile?Glu?Ala?Ala?Gly

35 40 45

cgt?gca?gca?aca?aat?ggc?acc?atc?gcc?cgc?atc?gga?ctg?acc?tac?cgc 192

Arg?Ala?Ala?Thr?Asn?Gly?Thr?Ile?Ala?Arg?Ile?Gly?Leu?Thr?Tyr?Arg

50 55 60

cgt?tcc?cca?ggc?gtg?gca?cac?atc?cgt?gat?ctc?gtg?cag?tcc?ggc?gag 240

Arg?Ser?Pro?Gly?Val?Ala?His?Ile?Arg?Asp?Leu?Val?Gln?Ser?Gly?Glu

65 70 75 80

ctt?ggc?aag?gtt?cta?cac?gtc?acc?ggc?cac?tac?tgg?acc?gac?tac?gga 288

Leu?Gly?Lys?Val?Leu?His?Val?Thr?Gly?His?Tyr?Trp?Thr?Asp?Tyr?Gly

85 90 95

tcc?aat?gca?cag?gca?cca?atc?agc?tgg?cgt?tac?aag?ggg?cca?aac?ggc 336

Ser?Asn?Ala?Gln?Ala?Pro?Ile?Ser?Trp?Arg?Tyr?Lys?Gly?Pro?Asn?Gly

100 105 110

tcc?ggc?gca?ctg?gca?gat?gtg?gga?agc?cac?ctc?acc?tac?ctg?gca?gaa 384

Ser?Gly?Ala?Leu?Ala?Asp?Val?Gly?Ser?His?Leu?Thr?Tyr?Leu?Ala?Glu

115 120 125

ttc?gtt?gca?gga?tct?gac?ttc?gcc?gcc?gtc?cgt?ggt?ggc?cag?ttg?tcc 432

Phe?Val?Ala?Gly?Ser?Asp?Phe?Ala?Ala?Val?Arg?Gly?Gly?Gln?Leu?Ser

130 135 140

acc?gtg?atc?acc?gag?cgc?ccc?aag?cca?ctc?ggc?gcg?att?gtc?ggc?cac 480

Thr?Val?Ile?Thr?Glu?Arg?Pro?Lys?Pro?Leu?Gly?Ala?Ile?Val?Gly?His

145 150 155 160

gaa?ggc?ggc?gca?gtt?tcc?gat?gaa?tac?gaa?gca?gtg?gaa?aat?gat?gac 528

Glu?Gly?Gly?Ala?Val?Ser?Asp?Glu?Tyr?Glu?Ala?Val?Glu?Asn?Asp?Asp

165 170 175

att?gca?tca?ttc?tcc?gga?tcc?ttc?atc?ggt?ggc?gga?acc?gca?acc?ctc 576

Ile?Ala?Ser?Phe?Ser?Gly?Ser?Phe?Ile?Gly?Gly?Gly?Thr?Ala?Thr?Leu

180 185 190

cag?gtc?agc?cgc?att?tcc?cag?gga?cac?cca?aac?acc?cta?ggt?ttt?gaa 624

Gln?Val?Ser?Arg?Ile?Ser?Gln?Gly?His?Pro?Asn?Thr?Leu?Gly?Phe?Glu

195 200 205

gtg?ttc?tgt?gaa?aag?ggc?tcc?gtg?ctc?ttt?gat?ttc?cgc?aac?tca?ggc 672

Val?Phe?Cys?Glu?Lys?Gly?Ser?Val?Leu?Phe?Asp?Phe?Arg?Asn?Ser?Gly

210 215 220

gaa?ttc?aaa?atc?ttc?acc?cca?gca?acc?tcc?ggt?gac?atc?agc?caa?gaa 720

Glu?Phe?Lys?Ile?Phe?Thr?Pro?Ala?Thr?Ser?Gly?Asp?Ile?Ser?Gln?Glu

225 230 235 240

gcc?ggc?tac?cgc?acc?atc?acc?atc?gga?cca?aag?cac?cca?tac?tgg?cgc 768

Ala?Gly?Tyr?Arg?Thr?Ile?Thr?Ile?Gly?Pro?Lys?His?Pro?Tyr?Trp?Arg

245 250 255

ggc?ggc?ctt?gca?atg?gat?gca?cca?ggc?gtg?gga?att?ggc?caa?aac?gaa 816

Gly?Gly?Leu?Ala?Met?Asp?Ala?Pro?Gly?Val?Gly?Ile?Gly?Gln?Asn?Glu

260 265 270

ggc?ttc?gtt?ttc?cag?gcg?cgc?gca?ttc?ctc?gaa?gaa?atc?gca?gga?atc 864

Gly?Phe?Val?Phe?Gln?Ala?Arg?Ala?Phe?Leu?Glu?Glu?Ile?Ala?Gly?Ile

275 280 285

tcc?gaa?gct?gaa?agc?ctg?cca?cgc?tgc?gca?act?ttg?gaa?gaa?ggg?cta 912

Ser?Glu?Ala?Glu?Ser?Leu?Pro?Arg?Cys?Ala?Thr?Leu?Glu?Glu?Gly?Leu

290 295 300

cac?aat?atg?cag?ctc?att?gat?gct?gta?tca?cag?tca?gct?gca?gca?ggt 960

His?Asn?Met?Gln?Leu?Ile?Asp?Ala?Val?Ser?Gln?Ser?Ala?Ala?Ala?Gly

305 310 315 320

ggc?gaa?acc?gtt?gcg?gtc?cca?gcg?gct?gct?ctg?atc?cct?gca?aac?aac 1008

Gly?Glu?Thr?Val?Ala?Val?Pro?Ala?Ala?Ala?Leu?Ile?Pro?Ala?Asn?Asn

325 330 335

tagaaactat?tcagaaagca?tca 1031

<210>494

<211>336

<212>PRT

＜213〉Corynebacterium glutamicum

<400>494

Ile?Asp?Val?Val?Ser?Val?Val?Val?Ala?Asn?Phe?Leu?His?Arg?Glu?Ile

1 5 10 15

Val?Glu?Ala?Leu?Leu?Ala?Ser?Gly?Lys?His?Val?Leu?Cys?Glu?Lys?Pro

20 25 30

Leu?Ser?Asp?Thr?Ile?Glu?Asp?Ala?Glu?Ala?Met?Ile?Glu?Ala?Ala?Gly

35 40 45

Arg?Ala?Ala?Thr?Asn?Gly?Thr?Ile?Ala?Arg?Ile?Gly?Leu?Thr?Tyr?Arg

50 55 60

Arg?Ser?Pro?Gly?Val?Ala?His?Ile?Arg?Asp?Leu?Val?Gln?Ser?Gly?Glu

65 70 75 80

Leu?Gly?Lys?Val?Leu?His?Val?Thr?Gly?His?Tyr?Trp?Thr?Asp?Tyr?Gly

85 90 95

Ser?Asn?Ala?Gln?Ala?Pro?Ile?Ser?Trp?Arg?Tyr?Lys?Gly?Pro?Asn?Gly

100 105 110

Ser?Gly?Ala?Leu?Ala?Asp?Val?Gly?Ser?His?Leu?Thr?Tyr?Leu?Ala?Glu

115 120 125

Phe?Val?Ala?Gly?Ser?Asp?Phe?Ala?Ala?Val?Arg?Gly?Gly?Gln?Leu?Ser

130 135 140

Thr?Val?Ile?Thr?Glu?Arg?Pro?Lys?Pro?Leu?Gly?Ala?Ile?Val?Gly?His

145 150 155 160

Glu?Gly?Gly?Ala?Val?Ser?Asp?Glu?Tyr?Glu?Ala?Val?Glu?Asn?Asp?Asp

165 170 175

Ile?Ala?Ser?Phe?Ser?Gly?Ser?Phe?Ile?Gly?Gly?Gly?Thr?Ala?Thr?Leu

180 185 190

Gln?Val?Ser?Arg?Ile?Ser?Gln?Gly?His?Pro?Asn?Thr?Leu?Gly?Phe?Glu

195 200 205

Val?Phe?Cys?Glu?Lys?Gly?Ser?Val?Leu?Phe?Asp?Phe?Arg?Asn?Ser?Gly

210 215 220

Glu?Phe?Lys?Ile?Phe?Thr?Pro?Ala?Thr?Ser?Gly?Asp?Ile?Ser?Gln?Glu

225 230 235 240

Ala?Gly?Tyr?Arg?Thr?Ile?Thr?Ile?Gly?Pro?Lys?His?Pro?Tyr?Trp?Arg

245 250 255

Gly?Gly?Leu?Ala?Met?Asp?Ala?Pro?Gly?Val?Gly?Ile?Gly?Gln?Asn?Glu

260 265 270

Gly?Phe?Val?Phe?Gln?Ala?Arg?Ala?Phe?Leu?Glu?Glu?Ile?Ala?Gly?Ile

275 280 285

Ser?Glu?Ala?Glu?Ser?Leu?Pro?Arg?Cys?Ala?Thr?Leu?Glu?Glu?Gly?Leu

290 295 300

His?Asn?Met?Gln?Leu?Ile?Asp?Ala?Val?Ser?Gln?Ser?Ala?Ala?Ala?Gly

305 310 315 320

Gly?Glu?Thr?Val?Ala?Val?Pro?Ala?Ala?Ala?Leu?Ile?Pro?Ala?Asn?Asn

325 330 335

<210>495

<211>1288

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1258)

<223>RXS03224

<400>495

acgattgtgc?tgtcgtttgc?gttggtgaat?agttctggac?cgggtatttt?gcggcgcaca?60

tggaactcat?tgaacgccgc?gcccggctaa?ggtgggaggc?atg?agt?ttt?gct?gaa 115

Met?Ser?Phe?Ala?Glu

1 5

cat?gcg?atc?atc?tgg?cac?gtc?tac?ccc?ctg?ggc?gct?ttg?ggt?gct?ccc 163

His?Ala?Ile?Ile?Trp?His?Val?Tyr?Pro?Leu?Gly?Ala?Leu?Gly?Ala?Pro

10 15 20

atc?cgg?cct?gaa?gcc?ccc?gca?cct?gtc?aca?cat?cgg?ctc?ccc?aat?cta 211

Ile?Arg?Pro?Glu?Ala?Pro?Ala?Pro?Val?Thr?His?Arg?Leu?Pro?Asn?Leu

25 30 35

att?ggg?tgg?ctg?gat?tat?gtt?gtc?gaa?cta?ggc?tgc?aac?gcc?ctc?atg 259

Ile?Gly?Trp?Leu?Asp?Tyr?Val?Val?Glu?Leu?Gly?Cys?Asn?Ala?Leu?Met

40 45 50

ctg?gga?ccg?gta?ttc?gag?tcc?gtc?agc?cac?ggc?tac?gac?acc?ctc?gat 307

Leu?Gly?Pro?Val?Phe?Glu?Ser?Val?Ser?His?Gly?Tyr?Asp?Thr?Leu?Asp

55 60 65

ttc?tac?cgc?atc?gac?ccg?cgc?ctc?ggc?acc?gag?gaa?gac?atg?gac?gcg 355

Phe?Tyr?Arg?Ile?Asp?Pro?Arg?Leu?Gly?Thr?Glu?Glu?Asp?Met?Asp?Ala

70 75 80 85

ctg?ctg?gag?gct?gcg?aat?cag?cgg?ggc?att?gga?gtg?ctt?ttc?gac?ggc 403

Leu?Leu?Glu?Ala?Ala?Asn?Gln?Arg?Gly?Ile?Gly?Val?Leu?Phe?Asp?Gly

90 95 100

gtc?ttc?aat?cat?gtt?tcc?agt?tcc?tct?aaa?tat?ctc?gac?ctg?acc?acc 451

Val?Phe?Asn?His?Val?Ser?Ser?Ser?Ser?Lys?Tyr?Leu?Asp?Leu?Thr?Thr

105 110 115

ggg?gcg?tca?ttt?gaa?ggc?cac?gac?atc?ctg?gcg?gaa?ctc?gac?cac?acg 499

Gly?Ala?Ser?Phe?Glu?Gly?His?Asp?Ile?Leu?Ala?Glu?Leu?Asp?His?Thr

120 125 130

aat?ccc?gcc?gta?gtg?gat?ctg?gtt?gtc?gat?gtc?atg?aac?cac?tgg?ctc 547

Asn?Pro?Ala?Val?Val?Asp?Leu?Val?Val?Asp?Val?Met?Asn?His?Trp?Leu

135 140 145

gac?cgc?gga?atc?gca?ggc?tgg?cga?ctc?gac?gct?gtc?tac?gcc?atc?gcc 595

Asp?Arg?Gly?Ile?Ala?Gly?Trp?Arg?Leu?Asp?Ala?Val?Tyr?Ala?Ile?Ala

150 155 160 165

cct?gaa?ttt?tgg?gaa?aaa?gtc?ctg?cca?gaa?gtg?cga?cga?aaa?cac?cca 643

Pro?Glu?Phe?Trp?Glu?Lys?Val?Leu?Pro?Glu?Val?Arg?Arg?Lys?His?Pro

170 175 180

cac?gca?tgg?atc?gtg?ggg?gag?atg?atc?cat?gga?gat?tac?tcc?gac?tac 691

His?Ala?Trp?Ile?Val?Gly?Glu?Met?Ile?His?Gly?Asp?Tyr?Ser?Asp?Tyr

185 190 195

gtg?aaa?agc?tcc?ggc?att?gat?tcc?gtt?acc?gaa?tac?gaa?ctg?tgg?aaa 739

Val?Lys?Ser?Ser?Gly?Ile?Asp?Ser?Val?Thr?Glu?Tyr?Glu?Leu?Trp?Lys

200 205 210

gcc?att?tgg?agc?agc?atc?aaa?gag?cgc?aat?ttc?ttt?gaa?ctc?gaa?tgg 787

Ala?Ile?Trp?Ser?Ser?Ile?Lys?Glu?Arg?Asn?Phe?Phe?Glu?Leu?Glu?Trp

215 220 225

act?ttg?agt?cgc?cac?aat?gaa?ttc?ctc?gat?act?ttc?gta?ccg?cag?aca 835

Thr?Leu?Ser?Arg?His?Asn?Glu?Phe?Leu?Asp?Thr?Phe?Val?Pro?Gln?Thr

230 235 240 245

ttc?att?ggt?aac?cat?gac?gtc?acc?cgc?att?gcc?acc?cga?atc?ggt?caa 883

Phe?Ile?Gly?Asn?His?Asp?Val?Thr?Arg?Ile?Ala?Thr?Arg?Ile?Gly?Gln

250 255 260

tca?aat?gcg?atc?ctg?gcc?gca?gcg?atc?ctc?ttc?acg?gtc?gga?gga?acc 931

Ser?Asn?Ala?Ile?Leu?Ala?Ala?Ala?Ile?Leu?Phe?Thr?Val?Gly?Gly?Thr

265 270 275

cca?agc?att?tac?tac?ggc?gat?gag?cag?ggc?ttt?acg?gga?ttg?aaa?gag 979

Pro?Ser?Ile?Tyr?Tyr?Gly?Asp?Glu?Gln?Gly?Phe?Thr?Gly?Leu?Lys?Glu

280 285 290

gat?aac?gtt?ttc?ggt?gac?gat?gcc?att?agg?cca?cct?ctt?cct?gcc?gag 1027

Asp?Asn?Val?Phe?Gly?Asp?Asp?Ala?Ile?Arg?Pro?Pro?Leu?Pro?Ala?Glu

295 300 305

ttt?tct?cca?ctg?ggc?acc?tgg?att?gaa?aac?att?tat?aag?gct?ctg?atc 1075

Phe?Ser?Pro?Leu?Gly?Thr?Trp?Ile?Glu?Asn?Ile?Tyr?Lys?Ala?Leu?Ile

310 315 320 325

gcg?ctg?cgc?agg?caa?cac?ccg?tgg?ttg?tat?cag?gcg?cac?acc?gaa?gtc 1123

Ala?Leu?Arg?Arg?Gln?His?Pro?Trp?Leu?Tyr?Gln?Ala?His?Thr?Glu?Val

330 335 340

ctt?gag?att?gct?aat?gaa?gcg?atg?acc?tat?aag?tcc?gtc?ggt?ctt?gga 1171

Leu?Glu?Ile?Ala?Asn?Glu?Ala?Met?Thr?Tyr?Lys?Ser?Val?Gly?Leu?Gly

345 350 355

ggt?gaa?gag?ctg?aca?gtg?cat?ctt?gat?ttg?gaa?gag?gtg?tct?gtt?cgg 1219

Gly?Glu?Glu?Leu?Thr?Val?His?Leu?Asp?Leu?Glu?Glu?Val?Ser?Val?Arg

360 365 370

atc?ctt?gat?ggc?gag?aag?gtg?ctg?ttt?cag?tac?agc?gct?tagttgtcgg 1268

Ile?Leu?Asp?Gly?Glu?Lys?Val?Leu?Phe?Gln?Tyr?Ser?Ala

375 380 385

ttcaagggta?ggggaacaaa 1288

<210>496

<211>386

<212>PRT

＜213〉Corynebacterium glutamicum

<400>496

Met?Ser?Phe?Ala?Glu?His?Ala?Ile?Ile?Trp?His?Val?Tyr?Pro?Leu?Gly

1 5 10 15

Ala?Leu?Gly?Ala?Pro?Ile?Arg?Pro?Glu?Ala?Pro?Ala?Pro?Val?Thr?His

20 25 30

Arg?Leu?Pro?Asn?Leu?Ile?Gly?Trp?Leu?Asp?Tyr?Val?Val?Glu?Leu?Gly

35 40 45

Cys?Asn?Ala?Leu?Met?Leu?Gly?Pro?Val?Phe?Glu?Ser?Val?Ser?His?Gly

50 55 60

Tyr?Asp?Thr?Leu?Asp?Phe?Tyr?Arg?Ile?Asp?Pro?Arg?Leu?Gly?Thr?Glu

65 70 75 80

Glu?Asp?Met?Asp?Ala?Leu?Leu?Glu?Ala?Ala?Asn?Gln?Arg?Gly?Ile?Gly

85 90 95

Val?Leu?Phe?Asp?Gly?Val?Phe?Asn?His?Val?Ser?Ser?Ser?Ser?Lys?Tyr

100 105 110

Leu?Asp?Leu?Thr?Thr?Gly?Ala?Ser?Phe?Glu?Gly?His?Asp?Ile?Leu?Ala

115 120 125

Glu?Leu?Asp?His?Thr?Asn?Pro?Ala?Val?Val?Asp?Leu?Val?Val?Asp?Val

130 135 140

Met?Asn?His?Trp?Leu?Asp?Arg?Gly?Ile?Ala?Gly?Trp?Arg?Leu?Asp?Ala

145 150 155 160

Val?Tyr?Ala?Ile?Ala?Pro?Glu?Phe?Trp?Glu?Lys?Val?Leu?Pro?Glu?Val

165 170 175

Arg?Arg?Lys?His?Pro?His?Ala?Trp?Ile?Val?Gly?Glu?Met?Ile?His?Gly

180 185 190

Asp?Tyr?Ser?Asp?Tyr?Val?Lys?Ser?Ser?Gly?Ile?Asp?Ser?Val?Thr?Glu

195 200 205

Tyr?Glu?Leu?Trp?Lys?Ala?Ile?Trp?Ser?Ser?Ile?Lys?Glu?Arg?Asn?Phe

210 215 220

Phe?Glu?Leu?Glu?Trp?Thr?Leu?Ser?Arg?His?Asn?Glu?Phe?Leu?Asp?Thr

225 230 235 240

Phe?Val?Pro?Gln?Thr?Phe?Ile?Gly?Asn?His?Asp?Val?Thr?Arg?Ile?Ala

245 250 255

Thr?Arg?Ile?Gly?Gln?Ser?Asn?Ala?Ile?Leu?Ala?Ala?Ala?Ile?Leu?Phe

260 265 270

Thr?Val?Gly?Gly?Thr?Pro?Ser?Ile?Tyr?Tyr?Gly?Asp?Glu?Gln?Gly?Phe

275 280 285

Thr?Gly?Leu?Lys?Glu?Asp?Asn?Val?Phe?Gly?Asp?Asp?Ala?Ile?Arg?Pro

290 295 300

Pro?Leu?Pro?Ala?Glu?Phe?Ser?Pro?Leu?Gly?Thr?Trp?Ile?Glu?Asn?Ile

305 310 315 320

Tyr?Lys?Ala?Leu?Ile?Ala?Leu?Arg?Arg?Gln?His?Pro?Trp?Leu?Tyr?Gln

325 330 335

Ala?His?Thr?Glu?Val?Leu?Glu?Ile?Ala?Asn?Glu?Ala?Met?Thr?Tyr?Lys

340 345 350

Ser?Val?Gly?Leu?Gly?Gly?Glu?Glu?Leu?Thr?Val?His?Leu?Asp?Leu?Glu

355 360 365

Glu?Val?Ser?Val?Arg?Ile?Leu?Asp?Gly?Glu?Lys?Val?Leu?Phe?Gln?Tyr

370 375 380

Ser?Ala

385

<210>497

<211>1281

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1258)

<223>FRXA00038

<400>497

acgattgtgc?tgtcgtttgc?gttggtgaat?agttctggac?cgggtatttt?gcggcgcaca?60

tggaactcat?tgaacgccgc?gcccggctaa?ggtgggaggc?atg?agt?ttt?gct?gaa 115

Met?Ser?Phe?Ala?Glu

1 5

cat?gcg?atc?atc?tgg?cac?gtc?tac?ccc?ctg?ggc?gct?ttg?ggt?gct?ccc 163

His?Ala?Ile?Ile?Trp?His?Val?Tyr?Pro?Leu?Gly?Ala?Leu?Gly?Ala?Pro

10 15 20

atc?cgg?cct?gaa?gcc?ccc?gca?cct?gtc?aca?cat?cgg?ctc?ccc?aat?cta 211

Ile?Arg?Pro?Glu?Ala?Pro?Ala?Pro?Val?Thr?His?Arg?Leu?Pro?Asn?Leu

25 30 35

att?ggg?tgg?ctg?gat?tat?gtt?gtc?gaa?cta?ggc?tgc?aac?gcc?ctc?atg 259

Ile?Gly?Trp?Leu?Asp?Tyr?Val?Val?Glu?Leu?Gly?Cys?Asn?Ala?Leu?Met

40 45 50

ctg?gga?ccg?gta?ttc?gag?tcc?gtc?agc?cac?ggc?tac?gac?acc?ctc?gat 307

Leu?Gly?Pro?Val?Phe?Glu?Ser?Val?Ser?His?Gly?Tyr?Asp?Thr?Leu?Asp

55 60 65

ttc?tac?cgc?atc?gac?ccg?cgc?ctc?ggc?acc?gag?gaa?gac?atg?gac?gcg 355

Phe?Tyr?Arg?Ile?Asp?Pro?Arg?Leu?Gly?Thr?Glu?Glu?Asp?Met?Asp?Ala

70 75 80 85

ctg?ctg?gag?gct?gcg?aat?cag?cgg?ggc?att?gga?gtg?ctt?ttc?gac?ggc 403

Leu?Leu?Glu?Ala?Ala?Asn?Gln?Arg?Gly?Ile?Gly?Val?Leu?Phe?Asp?Gly

90 95 100

gtc?ttc?aat?cat?gtt?tcc?agt?tcc?tct?aaa?tat?ctc?gac?ctg?acc?acc 451

Val?Phe?Asn?His?Val?Ser?Ser?Ser?Ser?Lys?Tyr?Leu?Asp?Leu?Thr?Thr

105 110 115

ggg?gcg?tca?ttt?gaa?ggc?cac?gac?atc?ctg?gcg?gaa?ctc?gac?cac?acg 499

Gly?Ala?Ser?Phe?Glu?Gly?His?Asp?Ile?Leu?Ala?Glu?Leu?Asp?His?Thr

120 125 130

aat?ccc?gcc?gta?gtg?gat?ctg?gtt?gtc?gat?gtc?atg?aac?cac?tgg?ctc 547

Asn?Pro?Ala?Val?Val?Asp?Leu?Val?Val?Asp?Val?Met?Asn?His?Trp?Leu

135 140 145

gac?cgc?gga?atc?gca?ggc?tgg?cga?ctc?gac?gct?gtc?tac?gcc?atc?gcc 595

Asp?Arg?Gly?Ile?Ala?Gly?Trp?Arg?Leu?Asp?Ala?Val?Tyr?Ala?Ile?Ala

150 155 160 165

cct?gaa?ttt?tgg?gaa?aaa?gtc?ctg?cca?gaa?gtg?cga?cga?aaa?cac?cca 643

Pro?Glu?Phe?Trp?Glu?Lys?Val?Leu?Pro?Glu?Val?Arg?Arg?Lys?His?Pro

170 175 180

cac?gca?tgg?atc?gtg?ggg?gag?atg?atc?cat?gga?gat?tac?tcc?gac?tac 691

His?Ala?Trp?Ile?Val?Gly?Glu?Met?Ile?His?Gly?Asp?Tyr?Ser?Asp?Tyr

185 190 195

gtg?aaa?agc?tcc?ggc?att?gat?tcc?gtt?acc?gaa?tac?gaa?ctg?tgg?aaa 739

Val?Lys?Ser?Ser?Gly?Ile?Asp?Ser?Val?Thr?Glu?Tyr?Glu?Leu?Trp?Lys

200 205 210

gcc?att?tgg?agc?agc?atc?aaa?gag?cgc?aat?ttc?ttt?gaa?ctc?gaa?tgg 787

Ala?Ile?Trp?Ser?Ser?Ile?Lys?Glu?Arg?Asn?Phe?Phe?Glu?Leu?Glu?Trp

215 220 225

act?ttg?agt?cgc?cac?aat?gaa?ttc?ctc?gat?act?ttc?gta?ccg?cag?aca 835

Thr?Leu?Ser?Arg?His?Asn?Glu?Phe?Leu?Asp?Thr?Phe?Val?Pro?Gln?Thr

230 235 240 245

ttc?att?ggt?aac?cat?gac?gtc?acc?cgc?att?gcc?acc?cga?atc?ggt?caa 883

Phe?Ile?Gly?Asn?His?Asp?Val?Thr?Arg?Ile?Ala?Thr?Arg?Ile?Gly?Gln

250 255 260

tca?aat?gcg?atc?ctg?gcc?gca?gcg?atc?ctc?ttc?acg?gtc?gga?gga?acc 931

Ser?Asn?Ala?Ile?Leu?Ala?Ala?Ala?Ile?Leu?Phe?Thr?Val?Gly?Gly?Thr

265 270 275

cca?agc?att?tac?tac?ggc?gat?gag?cag?ggc?ttt?acg?gga?ttg?aaa?gag 979

Pro?Ser?Ile?Tyr?Tyr?Gly?Asp?Glu?Gln?Gly?Phe?Thr?Gly?Leu?Lys?Glu

280 285 290

gat?aac?gtt?ttc?ggt?gac?gat?gcc?att?agg?cca?cct?ctt?cct?gcc?gag 1027

Asp?Asn?Val?Phe?Gly?Asp?Asp?Ala?Ile?Arg?Pro?Pro?Leu?Pro?Ala?Glu

295 300 305

ttt?tct?cca?ctg?ggc?acc?tgg?att?gaa?aac?att?tat?aag?gct?ctg?atc 1075

Phe?Ser?Pro?Leu?Gly?Thr?Trp?Ile?Glu?Asn?Ile?Tyr?Lys?Ala?Leu?Ile

310 315 320 325

gcg?ctg?cgc?agg?caa?cac?ccg?tgg?ttg?tat?cag?gcg?cac?acc?gaa?gtc 1123

Ala?Leu?Arg?Arg?Gln?His?Pro?Trp?Leu?Tyr?Gln?Ala?His?Thr?Glu?Val

330 335 340

ctt?gag?att?gct?aat?gaa?gcg?atg?acc?tat?aag?tcc?gtc?ggt?ctt?gga 1171

Leu?Glu?Ile?Ala?Asn?Glu?Ala?Met?Thr?Tyr?Lys?Ser?Val?Gly?Leu?Gly

345 350 355

ggt?gaa?gag?ctg?aca?gtg?cat?ctt?gat?ttg?gaa?gag?gtg?tct?gtt?cgg 1219

Gly?Glu?Glu?Leu?Thr?Val?His?Leu?Asp?Leu?Glu?Glu?Val?Ser?Val?Arg

360 365 370

atc?ctt?gat?ggc?gag?aag?gtg?ctg?ttt?cag?tac?agc?gct?tagttgtcgg 1268

Ile?Leu?Asp?Gly?Glu?Lys?Val?Leu?Phe?Gln?Tyr?Ser?Ala

375 380 385

ttcaagggta?ggg 1281

<210>498

<211>386

<212>PRT

＜213〉Corynebacterium glutamicum

<400>498

Met?Ser?Phe?Ala?Glu?His?Ala?Ile?Ile?Trp?His?Val?Tyr?Pro?Leu?Gly

1 5 10 15

Ala?Leu?Gly?Ala?Pro?Ile?Arg?Pro?Glu?Ala?Pro?Ala?Pro?Val?Thr?His

20 25 30

Arg?Leu?Pro?Asn?Leu?Ile?Gly?Trp?Leu?Asp?Tyr?Val?Val?Glu?Leu?Gly

35 40 45

Cys?Asn?Ala?Leu?Met?Leu?Gly?Pro?Val?Phe?Glu?Ser?Val?Ser?His?Gly

50 55 60

Tyr?Asp?Thr?Leu?Asp?Phe?Tyr?Arg?Ile?Asp?Pro?Arg?Leu?Gly?Thr?Glu

65 70 75 80

Glu?Asp?Met?Asp?Ala?Leu?Leu?Glu?Ala?Ala?Asn?Gln?Arg?Gly?Ile?Gly

85 90 95

Val?Leu?Phe?Asp?Gly?Val?Phe?Asn?His?Val?Ser?Ser?Ser?Ser?Lys?Tyr

100 105 110

Leu?Asp?Leu?Thr?Thr?Gly?Ala?Ser?Phe?Glu?Gly?His?Asp?Ile?Leu?Ala

115 120 125

Glu?Leu?Asp?His?Thr?Asn?Pro?Ala?Val?Val?Asp?Leu?Val?Val?Asp?Val

130 135 140

Met?Asn?His?Trp?Leu?Asp?Arg?Gly?Ile?Ala?Gly?Trp?Arg?Leu?Asp?Ala

145 150 155 160

Val?Tyr?Ala?Ile?Ala?Pro?Glu?Phe?Trp?Glu?Lys?Val?Leu?Pro?Glu?Val

165 170 175

Arg?Arg?Lys?His?Pro?His?Ala?Trp?Ile?Val?Gly?Glu?Met?Ile?His?Gly

180 185 190

Asp?Tyr?Ser?Asp?Tyr?Val?Lys?Ser?Ser?Gly?Ile?Asp?Ser?Val?Thr?Glu

195 200 205

Tyr?Glu?Leu?Trp?Lys?Ala?Ile?Trp?Ser?Ser?Ile?Lys?Glu?Arg?Asn?Phe

210 215 220

Phe?Glu?Leu?Glu?Trp?Thr?Leu?Ser?Arg?His?Asn?Glu?Phe?Leu?Asp?Thr

225 230 235 240

Phe?Val?Pro?Gln?Thr?Phe?Ile?Gly?Asn?His?Asp?Val?Thr?Arg?Ile?Ala

245 250 255

Thr?Arg?Ile?Gly?Gln?Ser?Asn?Ala?Ile?Leu?Ala?Ala?Ala?Ile?Leu?Phe

260 265 270

Thr?Val?Gly?Gly?Thr?Pro?Ser?Ile?Tyr?Tyr?Gly?Asp?Glu?Gln?Gly?Phe

275 280 285

Thr?Gly?Leu?Lys?Glu?Asp?Asn?Val?Phe?Gly?Asp?Asp?Ala?Ile?Arg?Pro

290 295 300

Pro?Leu?Pro?Ala?Glu?Phe?Ser?Pro?Leu?Gly?Thr?Trp?Ile?Glu?Asn?Ile

305 310 315 320

Tyr?Lys?Ala?Leu?Ile?Ala?Leu?Arg?Arg?Gln?His?Pro?Trp?Leu?Tyr?Gln

325 330 335

Ala?His?Thr?Glu?Val?Leu?Glu?Ile?Ala?Asn?Glu?Ala?Met?Thr?Tyr?Lys

340 345 350

Ser?Val?Gly?Leu?Gly?Gly?Glu?Glu?Leu?Thr?Val?His?Leu?Asp?Leu?Glu

355 360 365

Glu?Val?Ser?Val?Arg?Ile?Leu?Asp?Gly?Glu?Lys?Val?Leu?Phe?Gln?Tyr

370 375 380

Ser?Ala

385

<210>499

<211>517

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(517)

<223>RXC00233

<400>499

cgcctccagc?agttgaggga?gaagttccaa?cacttgcacc?aactgaggaa?gcaactgtgc?60

aatagcgctt?tagacacaga?ctcatgacag?aatagaagac?atg?agt?gtg?aat?gaa 115

Met?Ser?Val?Asn?Glu

1 5

gca?gat?ctg?aac?gct?gtc?gaa?gag?caa?ttg?gga?agg?gcc?cca?cga?ggt 163

Ala?Asp?Leu?Asn?Ala?Val?Glu?Glu?Gln?Leu?Gly?Arg?Ala?Pro?Arg?Gly

10 15 20

gtc?ctc?gat?att?tct?tac?cgc?agc?cct?gat?gga?gta?ccc?ggt?gtg?gtg 211

Val?Leu?Asp?Ile?Ser?Tyr?Arg?Ser?Pro?Asp?Gly?Val?Pro?Gly?Val?Val

25 30 35

atg?acc?gca?cca?aaa?ctg?gat?gac?gga?acc?cca?ttc?cca?acc?ctg?tac 259

Met?Thr?Ala?Pro?Lys?Leu?Asp?Asp?Gly?Thr?Pro?Phe?Pro?Thr?Leu?Tyr

40 45 50

tac?ttg?aca?gat?cca?cgc?ctg?acc?acc?gag?gca?tcc?cgc?ctc?gag?gtc 307

Tyr?Leu?Thr?Asp?Pro?Arg?Leu?Thr?Thr?Glu?Ala?Ser?Arg?Leu?Glu?Val

55 60 65

gca?ttg?gta?atg?aag?tgg?atg?act?gat?cgc?ctt?tcc?acc?gac?gaa?gag 355

Ala?Leu?Val?Met?Lys?Trp?Met?Thr?Asp?Arg?Leu?Ser?Thr?Asp?Glu?Glu

70 75 80 85

ctt?cgt?gcc?gac?tac?cag?cgc?gcc?cac?gag?cac?ttc?ctg?gca?aag?cgc 403

Leu?Arg?Ala?Asp?Tyr?Gln?Arg?Ala?His?Glu?His?Phe?Leu?Ala?Lys?Arg

90 95 100

aac?gca?att?gaa?gat?ctc?ggc?acg?gat?ttt?tcc?ggc?ggt?ggc?atg?cct 451

Asn?Ala?Ile?Glu?Asp?Leu?Gly?Thr?Asp?Phe?Ser?Gly?Gly?Gly?Met?Pro

105 110 115

gac?cga?gtg?aag?tgc?ctt?cac?gtc?ctc?att?gac?tat?gca?ctg?gca?gaa 499

Asp?Arg?Val?Lys?Cys?Leu?His?Val?Leu?Ile?Asp?Tyr?Ala?Leu?Ala?Glu

120 125 130

ggc?cca?cac?cat?ttc?ctt 517

Gly?Pro?His?His?Phe?Leu

135

<210>500

<211>139

<212>PRT

＜213〉Corynebacterium glutamicum

<400>500

Met?Ser?Val?Asn?Glu?Ala?Asp?Leu?Asn?Ala?Val?Glu?Glu?Gln?Leu?Gly

1 5 10 15

Arg?Ala?Pro?Arg?Gly?Val?Leu?Asp?Ile?Ser?Tyr?Arg?Ser?Pro?Asp?Gly

20 25 30

Val?Pro?Gly?Val?Val?Met?Thr?Ala?Pro?Lys?Leu?Asp?Asp?Gly?Thr?Pro

35 40 45

Phe?Pro?Thr?Leu?Tyr?Tyr?Leu?Thr?Asp?Pro?Arg?Leu?Thr?Thr?Glu?Ala

50 55 60

Ser?Arg?Leu?Glu?Val?Ala?Leu?Val?Met?Lys?Trp?Met?Thr?Asp?Arg?Leu

65 70 75 80

Ser?Thr?Asp?Glu?Glu?Leu?Arg?Ala?Asp?Tyr?Gln?Arg?Ala?His?Glu?His

85 90 95

Phe?Leu?Ala?Lys?Arg?Asn?Ala?Ile?Glu?Asp?Leu?Gly?Thr?Asp?Phe?Ser

100 105 110

Gly?Gly?Gly?Met?Pro?Asp?Arg?Val?Lys?Cys?Leu?His?Val?Leu?Ile?Asp

115 120 125

Tyr?Ala?Leu?Ala?Glu?Gly?Pro?His?His?Phe?Leu

130 135

<210>501

<211>849

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(826)

<223>RXC00236

<400>501

aatgcgagag?ttctaaaacg?agccggtaac?atcgaccccc?atgagttcag?gggttagaaa?60

agcaatggga?tttggatgcg?gttcggtttt?ggccgtcatc?atg?gtg?atc?tca?ttt 115

Met?Val?Ile?Ser?Phe

1 5

gtt?gga?tgg?gcg?ctc?agc?ttc?atg?gat?gga?acg?gca?cct?att?cgc?caa 163

Val?Gly?Trp?Ala?Leu?Ser?Phe?Met?Asp?Gly?Thr?Ala?Pro?Ile?Arg?Gln

10 15 20

ctc?cag?caa?atc?cct?gaa?gat?gtt?ccg?ccg?gcg?cgt?ggt?gta?gaa?gtt 211

Leu?Gln?Gln?Ile?Pro?Glu?Asp?Val?Pro?Pro?Ala?Arg?Gly?Val?Glu?Val

25 30 35

ccg?caa?att?gat?aca?gag?gca?gat?gga?cgc?aca?tcc?aac?cat?ttg?cgt 259

Pro?Gln?Ile?Asp?Thr?Glu?Ala?Asp?Gly?Arg?Thr?Ser?Asn?His?Leu?Arg

40 45 50

ttt?tgg?gcg?gaa?cca?att?gct?caa?gat?act?ggt?gtg?tcc?gct?caa?gcg 307

Phe?Trp?Ala?Glu?Pro?Ile?Ala?Gln?Asp?Thr?Gly?Val?Ser?Ala?Gln?Ala

55 60 65

att?gcg?gct?tat?gga?aac?gca?gag?ctc?atc?gcg?agt?act?gcg?tgg?cct 355

Ile?Ala?Ala?Tyr?Gly?Asn?Ala?Glu?Leu?Ile?Ala?Ser?Thr?Ala?Trp?Pro

70 75 80 85

ggc?tgc?aat?ctg?ggg?tgg?aat?acc?ttg?gca?ggt?atc?ggc?cag?gtg?gaa 403

Gly?Cys?Asn?Leu?Gly?Trp?Asn?Thr?Leu?Ala?Gly?Ile?Gly?Gln?Val?Glu

90 95 100

acc?cgt?cac?ggt?acc?tac?aac?ggc?aaa?atg?ttc?ggg?ggc?agt?tcc?ctg 451

Thr?Arg?His?Gly?Thr?Tyr?Asn?Gly?Lys?Met?Phe?Gly?Gly?Ser?Ser?Leu

105 110 115

gat?gaa?aat?gga?gtt?gca?acc?cct?cca?atc?atc?ggc?gtt?cca?ctt?gat 499

Asp?Glu?Asn?Gly?Val?Ala?Thr?Pro?Pro?Ile?Ile?Gly?Val?Pro?Leu?Asp

120 125 130

ggt?tca?ccg?ggg?ttt?gcg?gaa?att?ccc?gac?act?gat?ggt?ggg?gaa?tta 547

Gly?Ser?Pro?Gly?Phe?Ala?Glu?Ile?Pro?Asp?Thr?Asp?Gly?Gly?Glu?Leu

135 140 145

gat?ggc?gat?act?gaa?tat?gat?cgc?gcg?gta?ggt?ccc?atg?cag?ttc?att 595

Asp?Gly?Asp?Thr?Glu?Tyr?Asp?Arg?Ala?Val?Gly?Pro?Met?Gln?Phe?Ile

150 155 160 165

ccg?gaa?acg?tgg?cga?ctt?atg?gga?ttg?gat?gca?aac?ggt?gat?ggg?gta 643

Pro?Glu?Thr?Trp?Arg?Leu?Met?Gly?Leu?Asp?Ala?Asn?Gly?Asp?Gly?Val

170 175 180

gcg?gac?ccc?aac?caa?att?gat?gac?gca?gca?ttg?agt?gcc?gca?aac?ctg 691

Ala?Asp?Pro?Asn?Gln?Ile?Asp?Asp?Ala?Ala?Leu?Ser?Ala?Ala?Asn?Leu

185 190 195

ttg?tgt?tcc?aac?gat?cgt?gac?ttg?tcc?act?cct?gaa?gga?tgg?acc?gca 739

Leu?Cys?Ser?Asn?Asp?Arg?Asp?Leu?Ser?Thr?Pro?Glu?Gly?Trp?Thr?Ala

200 205 210

gct?gtt?cat?tct?tac?aac?atg?tct?aat?cag?tat?ttg?atg?gac?gtt?cga 787

Ala?Val?His?Ser?Tyr?Asn?Met?Ser?Asn?Gln?Tyr?Leu?Met?Asp?Val?Arg

215 220 225

gat?gct?gcc?gcg?tcc?tac?gct?tta?cga?cag?ccg?gcg?atc?taaaacttaa 836

Asp?Ala?Ala?Ala?Ser?Tyr?Ala?Leu?Arg?Gln?Pro?Ala?Ile

230 235 240

caagcgcaac?ccc 849

<210>502

<211>242

<212>PRT

＜213〉Corynebacterium glutamicum

<400>502

Met?Val?Ile?Ser?Phe?Val?Gly?Trp?Ala?Leu?Ser?Phe?Met?Asp?Gly?Thr

1 5 10 15

Ala?Pro?Ile?Arg?Gln?Leu?Gln?Gln?Ile?Pro?Glu?Asp?Val?Pro?Pro?Ala

20 25 30

Arg?Gly?Val?Glu?Val?Pro?Gln?Ile?Asp?Thr?Glu?Ala?Asp?Gly?Arg?Thr

35 40 45

Ser?Asn?His?Leu?Arg?Phe?Trp?Ala?Glu?Pro?Ile?Ala?Gln?Asp?Thr?Gly

50 55 60

Val?Ser?Ala?Gln?Ala?Ile?Ala?Ala?Tyr?Gly?Asn?Ala?Glu?Leu?Ile?Ala

65 70 75 80

Ser?Thr?Ala?Trp?Pro?Gly?Cys?Asn?Leu?Gly?Trp?Asn?Thr?Leu?Ala?Gly

85 90 95

Ile?Gly?Gln?Val?Glu?Thr?Arg?His?Gly?Thr?Tyr?Asn?Gly?Lys?Met?Phe

100 105 110

Gly?Gly?Ser?Ser?Leu?Asp?Glu?Asn?Gly?Val?Ala?Thr?Pro?Pro?Ile?Ile

115 120 125

Gly?Val?Pro?Leu?Asp?Gly?Ser?Pro?Gly?Phe?Ala?Glu?Ile?Pro?Asp?Thr

130 135 140

Asp?Gly?Gly?Glu?Leu?Asp?Gly?Asp?Thr?Glu?Tyr?Asp?Arg?Ala?Val?Gly

145 150 155 160

Pro?Met?Gln?Phe?Ile?Pro?Glu?Thr?Trp?Arg?Leu?Met?Gly?Leu?Asp?Ala

165 170 175

Asn?Gly?Asp?Gly?Val?Ala?Asp?Pro?Asn?Gln?Ile?Asp?Asp?Ala?Ala?Leu

180 185 190

Ser?Ala?Ala?Asn?Leu?Leu?Cys?Ser?Asn?Asp?Arg?Asp?Leu?Ser?Thr?Pro

195 200 205

Glu?Gly?Trp?Thr?Ala?Ala?Val?His?Ser?Tyr?Asn?Met?Ser?Asn?Gln?Tyr

210 215 220

Leu?Met?Asp?Val?Arg?Asp?Ala?Ala?Ala?Ser?Tyr?Ala?Leu?Arg?Gln?Pro

225 230 235 240

Ala?Ile

<210>503

<211>1113

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1090)

<223>RXC00271

<400>503

tagtttaaat?catgagacat?ttcacatatg?gttctttatc?cgagacatgt?gttgacgctg?60

tctgcccctt?tttgaaaata?acactttaag?gagatgtgcc?atg?ttt?tct?tcc?cgt 115

Met?Phe?Ser?Ser?Arg

1 5

tcg?aag?gta?ctc?gca?agc?atc?ttt?act?gtt?ggc?gcc?ttg?gcg?ttg?gct 163

Ser?Lys?Val?Leu?Ala?Ser?Ile?Phe?Thr?Val?Gly?Ala?Leu?Ala?Leu?Ala

10 15 20

tcg?tgc?tca?agc?gat?tcc?agt?gac?agc?tcc?acc?tcc?act?gat?gct?gca 211

Ser?Cys?Ser?Ser?Asp?Ser?Ser?Asp?Ser?Ser?Thr?Ser?Thr?Asp?Ala?Ala

25 30 35

ggt?ggc?gac?tct?tac?cga?gtt?ggc?atc?aac?cag?ctt?gtt?cag?cac?cct 259

Gly?Gly?Asp?Ser?Tyr?Arg?Val?Gly?Ile?Asn?Gln?Leu?Val?Gln?His?Pro

40 45 50

gca?ctt?gat?gca?gcg?acc?act?ggt?ttc?aag?gaa?gct?ttt?gaa?gag?gca 307

Ala?Leu?Asp?Ala?Ala?Thr?Thr?Gly?Phe?Lys?Glu?Ala?Phe?Glu?Glu?Ala

55 60 65

ggc?gtt?gac?gtc?acc?ttt?gat?gag?caa?aac?gct?aac?ggc?gag?cag?ggc 355

Gly?Val?Asp?Val?Thr?Phe?Asp?Glu?Gln?Asn?Ala?Asn?Gly?Glu?Gln?Gly

70 75 80 85

act?gca?ctg?act?att?tct?cag?cag?ttc?gct?tct?gac?aat?ttg?gat?ctc 403

Thr?Ala?Leu?Thr?Ile?Ser?Gln?Gln?Phe?Ala?Ser?Asp?Asn?Leu?Asp?Leu

90 95 100

gtg?ttg?gct?gtt?gca?act?cca?gca?gca?cag?gca?act?gcg?cag?aat?atc 451

Val?Leu?Ala?Val?Ala?Thr?Pro?Ala?Ala?Gln?Ala?Thr?Ala?Gln?Asn?Ile

105 110 115

act?gat?atc?cca?gtc?ctg?ttc?acc?gca?gtt?acc?gat?gca?gtg?tcg?gca 499

Thr?Asp?Ile?Pro?Val?Leu?Phe?Thr?Ala?Val?Thr?Asp?Ala?Val?Ser?Ala

120 125 130

gag?ctg?gtg?gat?tct?aat?gaa?gca?cct?ggc?gga?aac?gtc?acc?ggt?act 547

Glu?Leu?Val?Asp?Ser?Asn?Glu?Ala?Pro?Gly?Gly?Asn?Val?Thr?Gly?Thr

135 140 145

tct?gat?atc?gca?ccg?att?gag?cag?cag?ttg?gag?ctt?ttg?cag?cag?ctg 595

Ser?Asp?Ile?Ala?Pro?Ile?Glu?Gln?Gln?Leu?Glu?Leu?Leu?Gln?Gln?Leu

150 155 160 165

gtt?cct?gac?gca?aag?tcc?atc?ggc?atc?gtc?tac?gcg?tct?ggt?gag?gtc 643

Val?Pro?Asp?Ala?Lys?Ser?Ile?Gly?Ile?Val?Tyr?Ala?Ser?Gly?Glu?Val

170 175 180

aac?tct?cag?gtg?cag?gtc?gat?gag?gtc?acc?aag?gct?gct?gag?cca?ctg 691

Asn?Ser?Gln?Val?Gln?Val?Asp?Glu?Val?Thr?Lys?Ala?Ala?Glu?Pro?Leu

185 190 195

ggg?ctg?tcc?gtt?aat?act?cag?act?gtc?act?acc?gtg?aac?gag?att?cag 739

Gly?Leu?Ser?Val?Asn?Thr?Gln?Thr?Val?Thr?Thr?Val?Asn?Glu?Ile?Gln

200 205 210

cag?gct?gtt?gaa?gct?ctc?ggc?gat?gtt?gat?gtc?atc?tac?gtt?cca?act 787

Gln?Ala?Val?Glu?Ala?Leu?Gly?Asp?Val?Asp?Val?Ile?Tyr?Val?Pro?Thr

215 220 225

gac?aac?atg?gtt?gtt?tcc?ggt?att?tct?tct?ctg?gtt?cag?gtt?gct?gag 835

Asp?Asn?Met?Val?Val?Ser?Gly?Ile?Ser?Ser?Leu?Val?Gln?Val?Ala?Glu

230 235 240 245

cag?aag?cag?atc?cct?gtg?atc?ggc?gct?gag?tcc?ggc?act?gtt?gag?ggt 883

Gln?Lys?Gln?Ile?Pro?Val?Ile?Gly?Ala?Glu?Ser?Gly?Thr?Val?Glu?Gly

250 255 260

ggc?gca?ctg?gca?acc?ctg?ggt?atc?gat?tac?acc?gag?ctt?ggc?cgc?cag 931

Gly?Ala?Leu?Ala?Thr?Leu?Gly?Ile?Asp?Tyr?Thr?Glu?Leu?Gly?Arg?Gln

265 270 275

act?ggt?gag?atg?gct?ctg?cgt?att?ctg?cag?gac?ggc?gaa?gac?cca?gca 979

Thr?Gly?Glu?Met?Ala?Leu?Arg?Ile?Leu?Gln?Asp?Gly?Glu?Asp?Pro?Ala

280 285 290

acc?atg?cct?gtg?gag?act?gca?act?gag?ttc?acc?tac?gtg?atc?aac?gaa 1027

Thr?Met?Pro?Val?Glu?Thr?Ala?Thr?Glu?Phe?Thr?Tyr?Val?Ile?Asn?Glu

295 300 305

gat?gca?gca?gag?cgc?cag?ggc?gtg?gag?atc?cct?caa?gag?att?ttg?gat 1075

Asp?Ala?Ala?Glu?Arg?Gln?Gly?Val?Glu?Ile?Pro?Gln?Glu?Ile?Leu?Asp

310 315 320 325

aag?gcc?gaa?cgc?gta?tgatcggcgc?ttttgagttc?gga 1113

Lys?Ala?Glu?Arg?Val

330

<210>504

<211>330

<212>PRT

＜213〉Corynebacterium glutamicum

<400>504

Met?Phe?Ser?Ser?Arg?Ser?Lys?Val?Leu?Ala?Ser?Ile?Phe?Thr?Val?Gly

1 5 10 15

Ala?Leu?Ala?Leu?Ala?Ser?Cys?Ser?Ser?Asp?Ser?Ser?Asp?Ser?Ser?Thr

20 25 30

Ser?Thr?Asp?Ala?Ala?Gly?Gly?Asp?Ser?Tyr?Arg?Val?Gly?Ile?Asn?Gln

35 40 45

Leu?Val?Gln?His?Pro?Ala?Leu?Asp?Ala?Ala?Thr?Thr?Gly?Phe?Lys?Glu

50 55 60

Ala?Phe?Glu?Glu?Ala?Gly?Val?Asp?Val?Thr?Phe?Asp?Glu?Gln?Asn?Ala

65 70 75 80

Asn?Gly?Glu?Gln?Gly?Thr?Ala?Leu?Thr?Ile?Ser?Gln?Gln?Phe?Ala?Ser

85 90 95

Asp?Asn?Leu?Asp?Leu?Val?Leu?Ala?Val?Ala?Thr?Pro?Ala?Ala?Gln?Ala

100 105 110

Thr?Ala?Gln?Asn?Ile?Thr?Asp?Ile?Pro?Val?Leu?Phe?Thr?Ala?Val?Thr

115 120 125

Asp?Ala?Val?Ser?Ala?Glu?Leu?Val?Asp?Ser?Asn?Glu?Ala?Pro?Gly?Gly

130 135 140

Asn?Val?Thr?Gly?Thr?Ser?Asp?Ile?Ala?Pro?Ile?Glu?Gln?Gln?Leu?Glu

145 150 155 160

Leu?Leu?Gln?Gln?Leu?Val?Pro?Asp?Ala?Lys?Ser?Ile?Gly?Ile?Val?Tyr

165 170 175

Ala?Ser?Gly?Glu?Val?Asn?Ser?Gln?Val?Gln?Val?Asp?Glu?Val?Thr?Lys

180 185 190

Ala?Ala?Glu?Pro?Leu?Gly?Leu?Ser?Val?Asn?Thr?Gln?Thr?Val?Thr?Thr

195 200 205

Val?Asn?Glu?Ile?Gln?Gln?Ala?Val?Glu?Ala?Leu?Gly?Asp?Val?Asp?Val

210 215 220

Ile?Tyr?Val?Pro?Thr?Asp?Asn?Met?Val?Val?Ser?Gly?Ile?Ser?Ser?Leu

225 230 235 240

Val?Gln?Val?Ala?Glu?Gln?Lys?Gln?Ile?Pro?Val?Ile?Gly?Ala?Glu?Ser

245 250 255

Gly?Thr?Val?Glu?Gly?Gly?Ala?Leu?Ala?Thr?Leu?Gly?Ile?Asp?Tyr?Thr

260 265 270

Glu?Leu?Gly?Arg?Gln?Thr?Gly?Glu?Met?Ala?Leu?Arg?Ile?Leu?Gln?Asp

275 280 285

Gly?Glu?Asp?Pro?Ala?Thr?Met?Pro?Val?Glu?Thr?Ala?Thr?Glu?Phe?Thr

290 295 300

Tyr?Val?Ile?Asn?Glu?Asp?Ala?Ala?Glu?Arg?Gln?Gly?Val?Glu?Ile?Pro

305 310 315 320

Gln?Glu?Ile?Leu?Asp?Lys?Ala?Glu?Arg?Val

325 330

<210>505

<211>1263

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1240)

<223>RXC00338

<400>505

tcttagaagg?cgtagtcaca?ccattaacct?tgccagaatt?tttcaaggct?tggctagact?60

tgggaaacga?acatgcggta?ccaaccaggg?gagttaatgc?gtg?agt?gat?gta?acc 115

Val?Ser?Asp?Val?Thr

1 5

gtt?ggc?gat?att?cgc?cgc?att?ttg?gat?gag?gct?tat?ccg?ccg?gcg?ttg 163

Val?Gly?Asp?Ile?Arg?Arg?Ile?Leu?Asp?Glu?Ala?Tyr?Pro?Pro?Ala?Leu

10 15 20

gcg?gaa?agc?tgg?gac?aaa?gtg?ggg?ctg?atc?tgc?ggt?gat?cca?aca?gag 211

Ala?Glu?Ser?Trp?Asp?Lys?Val?Gly?Leu?Ile?Cys?Gly?Asp?Pro?Thr?Glu

25 30 35

tcg?gtg?aag?cgt?gtc?ggt?tta?gca?ctc?gat?tgc?acc?cag?gca?gtg?gcc 259

Ser?Val?Lys?Arg?Val?Gly?Leu?Ala?Leu?Asp?Cys?Thr?Gln?Ala?Val?Ala

40 45 50

gac?aag?gct?gtg?gac?atg?ggt?ttg?gac?atg?ctg?atc?att?cac?cac?cca 307

Asp?Lys?Ala?Val?Asp?Met?Gly?Leu?Asp?Met?Leu?Ile?Ile?His?His?Pro

55 60 65

ttg?ctg?ctg?cgt?ggg?gtg?acg?tct?gtt?gct?gcg?gat?gag?cca?aaa?ggc 355

Leu?Leu?Leu?Arg?Gly?Val?Thr?Ser?Val?Ala?Ala?Asp?Glu?Pro?Lys?Gly

70 75 80 85

aag?gtc?att?cac?acc?cta?att?cgc?ggc?ggg?gtg?gca?ctg?ttt?tcc?gcg 403

Lys?Val?Ile?His?Thr?Leu?Ile?Arg?Gly?Gly?Val?Ala?Leu?Phe?Ser?Ala

90 95 100

cac?act?aat?gcg?gat?tcc?gcg?cgc?cca?ggt?gtc?aac?gat?aaa?ctc?gcc 451

His?Thr?Asn?Ala?Asp?Ser?Ala?Arg?Pro?Gly?Val?Asn?Asp?Lys?Leu?Ala

105 110 115

gag?ctc?gtc?ggc?atc?acg?gcc?ggg?cga?ccc?atc?gcg?aca?cgg?ctt?tta 499

Glu?Leu?Val?Gly?Ile?Thr?Ala?Gly?Arg?Pro?Ile?Ala?Thr?Arg?Leu?Leu

120 125 130

ggc?ggc?atg?gac?aaa?tgg?ggc?gtg?cac?gtt?ctg?ccc?aag?gat?gca?gcg 547

Gly?Gly?Met?Asp?Lys?Trp?Gly?Val?His?Val?Leu?Pro?Lys?Asp?Ala?Ala

135 140 145

tac?cta?aag?aag?atg?ctt?ttc?gac?gca?ggt?gcc?ggt?gcg?atc?ggc?gac 595

Tyr?Leu?Lys?Lys?Met?Leu?Phe?Asp?Ala?Gly?Ala?Gly?Ala?Ile?Gly?Asp

150 155 160 165

tac?cga?gag?tgt?gcc?ttt?gag?atc?gaa?gga?acc?ggg?cag?ttt?agg?ccc 643

Tyr?Arg?Glu?Cys?Ala?Phe?Glu?Ile?Glu?Gly?Thr?Gly?Gln?Phe?Arg?Pro

170 175 180

gtg?gag?ggg?gcg?aat?ccg?gca?gag?ggg?gac?gtc?gat?aag?ctt?ttt?aaa 691

Val?Glu?Gly?Ala?Asn?Pro?Ala?Glu?Gly?Asp?Val?Asp?Lys?Leu?Phe?Lys

185 190 195

tcc?ctt?gag?ctg?cgc?atc?gag?ttt?gtt?gca?ccg?cgc?aac?ctg?cgc?gcc 739

Ser?Leu?Glu?Leu?Arg?Ile?Glu?Phe?Val?Ala?Pro?Arg?Asn?Leu?Arg?Ala

200 205 210

cgg?ctc?acg?tcg?gtg?ctg?cgg?gag?gct?cat?ccg?tat?gag?gag?cct?gcc 787

Arg?Leu?Thr?Ser?Val?Leu?Arg?Glu?Ala?His?Pro?Tyr?Glu?Glu?Pro?Ala

215 220 225

ttc?gat?att?gtt?gaa?atg?cac?agc?gct?gag?agt?tta?gaa?aat?gcg?acc 835

Phe?Asp?Ile?Val?Glu?Met?His?Ser?Ala?Glu?Ser?Leu?Glu?Asn?Ala?Thr

230 235 240 245

gga?ttg?ggt?cgt?gtg?ggt?gaa?ttg?ccg?gag?ccg?atg?cgc?ctc?gcg?gat 883

Gly?Leu?Gly?Arg?Val?Gly?Glu?Leu?Pro?Glu?Pro?Met?Arg?Leu?Ala?Asp

250 255 260

ttc?gtg?caa?caa?gtg?gcc?aac?aac?ctg?cct?gtc?acc?gaa?tgg?ggc?gtg 931

Phe?Val?Gin?Gln?Val?Ala?Asn?Asn?Leu?Pro?Val?Thr?Glu?Trp?Gly?Val

265 270 275

cgc?gct?acc?ggc?gat?cct?gaa?caa?atg?gtg?tcc?cgt?gtg?gcg?gtt?tca 979

Arg?Ala?Thr?Gly?Asp?Pro?Glu?Gln?Met?Val?Ser?Arg?Val?Ala?Val?Ser

280 285 290

tca?ggg?tcg?ggt?gac?agt?ttc?tta?aac?gat?gtg?att?aag?ctc?gga?gtg 1027

Ser?Gly?Ser?Gly?Asp?Ser?Phe?Leu?Asn?Asp?Val?Ile?Lys?Leu?Gly?Val

295 300 305

gac?gtt?tat?gtc?act?tct?gat?ctg?cgc?cac?cat?cca?gtt?gat?gaa?tat 1075

Asp?Val?Tyr?Val?Thr?Ser?Asp?Leu?Arg?His?His?Pro?Val?Asp?Glu?Tyr

310 315 320 325

ctc?cga?gaa?ggt?ggc?cct?gca?gta?atc?gat?act?gca?cac?tgg?gcc?agc 1123

Leu?Arg?Glu?Gly?Gly?Pro?Ala?Val?Ile?Asp?Thr?Ala?His?Trp?Ala?Ser

330 335 340

gaa?ttt?cca?tgg?act?tcc?caa?gcc?caa?gaa?att?ttg?cag?gac?aaa?gcc 1171

Glu?Phe?Pro?Trp?Thr?Ser?Gln?Ala?Gln?Glu?Ile?Leu?Gln?Asp?Lys?Ala

345 350 355

cca?cag?gtt?gaa?gtt?gat?gtg?att?tcg?atc?cgc?aca?gac?ccc?tgg?acc 1219

Pro?Gln?Val?Glu?Val?Asp?Val?Ile?Ser?Ile?Arg?Thr?Asp?Pro?Trp?Thr

360 365 370

atg?tct?gcg?cga?gca?gtg?aac?taaattcttg?agaactaaaa?aag 1263

Met?Ser?Ala?Arg?Ala?Val?Asn

375 380

<210>506

<211>380

<212>PRT

＜213〉Corynebacterium glutamicum

<400>506

Val?Ser?Asp?Val?Thr?Val?Gly?Asp?Ile?Arg?Arg?Ile?Leu?Asp?Glu?Ala

1 5 10 15

Tyr?Pro?Pro?Ala?Leu?Ala?Glu?Ser?Trp?Asp?Lys?Val?Gly?Leu?Ile?Cys

20 25 30

Gly?Asp?Pro?Thr?Glu?Ser?Val?Lys?Arg?Val?Gly?Leu?Ala?Leu?Asp?Cys

35 40 45

Thr?Gln?Ala?Val?Ala?Asp?Lys?Ala?Val?Asp?Met?Gly?Leu?Asp?Met?Leu

50 55 60

Ile?Ile?His?His?Pro?Leu?Leu?Leu?Arg?Gly?Val?Thr?Ser?Val?Ala?Ala

65 70 75 80

Asp?Glu?Pro?Lys?Gly?Lys?Val?Ile?His?Thr?Leu?Ile?Arg?Gly?Gly?Val

85 90 95

Ala?Leu?Phe?Ser?Ala?His?Thr?Asn?Ala?Asp?Ser?Ala?Arg?Pro?Gly?Val

100 105 110

Asn?Asp?Lys?Leu?Ala?Glu?Leu?Val?Gly?Ile?Thr?Ala?Gly?Arg?Pro?Ile

115 120 125

Ala?Thr?Arg?Leu?Leu?Gly?Gly?Met?Asp?Lys?Trp?Gly?Val?His?Val?Leu

130 135 140

Pro?Lys?Asp?Ala?Ala?Tyr?Leu?Lys?Lys?Met?Leu?Phe?Asp?Ala?Gly?Ala

145 150 155 160

Gly?Ala?Ile?Gly?Asp?Tyr?Arg?Glu?Cys?Ala?Phe?Glu?Ile?Glu?Gly?Thr

165 170 175

Gly?Gln?Phe?Arg?Pro?Val?Glu?Gly?Ala?Asn?Pro?Ala?Glu?Gly?Asp?Val

180 185 190

Asp?Lys?Leu?Phe?Lys?Ser?Leu?Glu?Leu?Arg?Ile?Glu?Phe?Val?Ala?Pro

195 200 205

Arg?Asn?Leu?Arg?Ala?Arg?Leu?Thr?Ser?Val?Leu?Arg?Glu?Ala?His?Pro

210 215 220

Tyr?Glu?Glu?Pro?Ala?Phe?Asp?Ile?Val?Glu?Met?His?Ser?Ala?Glu?Ser

225 230 235 240

Leu?Glu?Asn?Ala?Thr?Gly?Leu?Gly?Arg?Val?Gly?Glu?Leu?Pro?Glu?Pro

245 250 255

Met?Arg?Leu?Ala?Asp?Phe?Val?Gln?Gln?Val?Ala?Asn?Asn?Leu?Pro?Val

260 265 270

Thr?Glu?Trp?Gly?Val?Arg?Ala?Thr?Gly?Asp?Pro?Glu?Gln?Met?Val?Ser

275 280 285

Arg?Val?Ala?Val?Ser?Ser?Gly?Ser?Gly?Asp?Ser?Phe?Leu?Asn?Asp?Val

290 295 300

Ile?Lys?Leu?Gly?Val?Asp?Val?Tyr?Val?Thr?Ser?Asp?Leu?Arg?His?His

305 310 315 320

Pro?Val?Asp?Glu?Tyr?Leu?Arg?Glu?Gly?Gly?Pro?Ala?Val?Ile?Asp?Thr

325 330 335

Ala?His?Trp?Ala?Ser?Glu?Phe?Pro?Trp?Thr?Ser?Gln?Ala?Gln?Glu?Ile

340 345 350

Leu?Gln?Asp?Lys?Ala?Pro?Gln?Val?Glu?Val?Asp?Val?Ile?Ser?Ile?Arg

355 360 365

Thr?Asp?Pro?Trp?Thr?Met?Ser?Ala?Arg?Ala?Val?Asn

370 375 380

<210>507

<211>1470

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1447)

<223>RXC00362

<400>507

cactttttgg?gtgaaaattc?cacgaagtta?atgccgcttt?aagtcaattc?aatcacatgt?60

aacatgctac?ggttttttcg?gtcacttaaa?ggaggcgctt?atg?gga?atc?att?gct 115

Met?Gly?Ile?Ile?Ala

1 5

ctg?ctc?gtt?ttt?atc?gca?att?gcc?gtg?ata?ttg?aat?gtg?ttt?ttg?aaa 163

Leu?Leu?Val?Phe?Ile?Ala?Ile?Ala?Val?Ile?Leu?Asn?Val?Phe?Leu?Lys

10 15 20

cga?gat?att?tca?gaa?gca?ttg?cta?gtt?gga?tta?gta?gga?act?gcg?ctt 211

Arg?Asp?Ile?Ser?Glu?Ala?Leu?Leu?Val?Gly?Leu?Val?Gly?Thr?Ala?Leu

25 30 35

gtc?ggc?ggt?gta?aat?gca?ccg?aca?tta?ctg?att?gat?gct?gta?gtg?gat 259

Val?Gly?Gly?Val?Asn?Ala?Pro?Thr?Leu?Leu?Ile?Asp?Ala?Val?Val?Asp

40 45 50

gct?gct?cag?tcg?gaa?gtt?act?ttc?gca?ggt?atg?gcc?ttt?gtt?ttc?atg 307

Ala?Ala?Gln?Ser?Glu?Val?Thr?Phe?Ala?Gly?Met?Ala?Phe?Val?Phe?Met

55 60 65

ggc?atc?gtt?gtg?caa?tca?act?gga?ttg?att?gat?cga?tta?atc?gca?atc 355

Gly?Ile?Val?Val?Gln?Ser?Thr?Gly?Leu?Ile?Asp?Arg?Leu?Ile?Ala?Ile

70 75 80 85

ctt?aac?tcg?att?ttt?ggt?cgg?ctt?cga?ggt?ggc?gca?ggt?tat?gtt?tcc 403

Leu?Asn?Ser?Ile?Phe?Gly?Arg?Leu?Arg?Gly?Gly?Ala?Gly?Tyr?Val?Ser

90 95 100

act?ctt?gga?tct?gcg?ctc?att?gga?ctc?atc?gct?gga?tca?acg?gct?gga 451

Thr?Leu?Gly?Ser?Ala?Leu?Ile?Gly?Leu?Ile?Ala?Gly?Ser?Thr?Ala?Gly

105 110 115

aac?tcc?gcg?acg?gtt?ggc?tca?gtg?acg?atc?cct?tgg?atg?aaa?aag?acg 499

Asn?Ser?Ala?Thr?Val?Gly?Ser?Val?Thr?Ile?Pro?Trp?Met?Lys?Lys?Thr

120 125 130

gga?tgg?act?gct?gaa?agg?tcc?gca?acg?tta?gtc?gcg?ggc?aac?tct?ggc 547

Gly?Trp?Thr?Ala?Glu?Arg?Ser?Ala?Thr?Leu?Val?Ala?Gly?Asn?Ser?Gly

135 140 145

ctt?ggt?gtt?gcg?ttg?cct?ccc?aat?tca?aca?atg?ttc?atc?att?ttg?gca 595

Leu?Gly?Val?Ala?Leu?Pro?Pro?Asn?Ser?Thr?Met?Phe?Ile?Ile?Leu?Ala

150 155 160 165

ttg?cca?gct?gca?gca?gct?tct?tcg?gcc?tct?cag?gtg?tac?att?gct?ttg 643

Leu?Pro?Ala?Ala?Ala?Ala?Ser?Ser?Ala?Ser?Gln?Val?Tyr?Ile?Ala?Leu

170 175 180

gct?tgt?ggt?ggt?gcg?tat?gca?gtg?ctc?tac?cgc?tta?gcg?gtc?gtc?ttt 691

Ala?Cys?Gly?Gly?Ala?Tyr?Ala?Val?Leu?Tyr?Arg?Leu?Ala?Val?Val?Phe

185 190 195

tac?tgg?aca?cgt?aaa?gat?aaa?att?cct?gcc?acc?cct?gat?gat?caa?cgg 739

Tyr?Trp?Thr?Arg?Lys?Asp?Lys?Ile?Pro?Ala?Thr?Pro?Asp?Asp?Gln?Arg

200 205 210

gtg?tca?ttc?ggt?gag?gca?atg?aag?act?gga?tgg?cgt?tca?ccg?ttg?atc 787

Val?Ser?Phe?Gly?Glu?Ala?Met?Lys?Thr?Gly?Trp?Arg?Ser?Pro?Leu?Ile

215 220 225

ttc?ctt?gga?att?ttg?atc?ccc?gta?atc?ctc?aca?atc?ggc?cca?ttg?tct 835

Phe?Leu?Gly?Ile?Leu?Ile?Pro?Val?Ile?Leu?Thr?Ile?Gly?Pro?Leu?Ser

230 235 240 245

gaa?tgg?tta?aag?aca?cat?gga?gtt?ggg?gag?tct?ggt?gtt?aaa?tcg?atg 883

Glu?Trp?Leu?Lys?Thr?His?Gly?Val?Gly?Glu?Ser?Gly?Val?Lys?Ser?Met

250 255 260

tcg?atc?atc?gtg?tgg?gtg?cca?att?ctg?att?acg?gca?att?gct?ctg?att 931

Ser?Ile?Ile?Val?Trp?Val?Pro?Ile?Leu?Ile?Thr?Ala?Ile?Ala?Leu?Ile

265 270 275

gaa?ggg?cgt?aaa?cga?att?gct?aac?aac?atg?gca?cac?ttt?agg?gtt?cag 979

Glu?Gly?Arg?Lys?Arg?Ile?Ala?Asn?Asn?Met?Ala?His?Phe?Arg?Val?Gln

280 285 290

atc?tcc?aag?gac?ttg?cca?caa?ttt?gcc?acc?gta?gga?att?tcg?ttg?ttt 1027

Ile?Ser?Lys?Asp?Leu?Pro?Gln?Phe?Ala?Thr?Val?Gly?Ile?Ser?Leu?Phe

295 300 305

tct?gcg?ctt?gca?gca?gcg?aac?atc?atg?gaa?gaa?ctg?ggt?gtt?ggc?ccg 1075

Ser?Ala?Leu?Ala?Ala?Ala?Asn?Ile?Met?Glu?Glu?Leu?Gly?Val?Gly?Pro

310 315 320 325

cag?ttg?tct?aac?tgg?ctt?gat?tcc?atg?gac?cta?cct?aag?tct?gtc?atg 1123

Gln?Leu?Ser?Asn?Trp?Leu?Asp?Ser?Met?Asp?Leu?Pro?Lys?Ser?Val?Met

330 335 340

gtg?atc?att?gtc?tgc?atc?atg?tgc?att?gtg?gtg?gca?acg?cca?ctg?tcg 1171

Val?Ile?Ile?Val?Cys?Ile?Met?Cys?Ile?Val?Val?Ala?Thr?Pro?Leu?Ser

345 350 355

tca?aca?gca?acc?gcg?gct?gcg?att?ggt?gct?ccc?gct?gtc?gct?gcg?ttg 1219

Ser?Thr?Ala?Thr?Ala?Ala?Ala?Ile?Gly?Ala?Pro?Ala?Val?Ala?Ala?Leu

360 365 370

gct?gcg?gta?ggt?att?gat?cca?act?gtg?gcg?atc?gta?gtg?atc?ttg?ctg 1267

Ala?Ala?Val?Gly?Ile?Asp?Pro?Thr?Val?Ala?Ile?Val?Val?Ile?Leu?Leu

375 380 385

tgc?act?tcc?act?gaa?ggt?gca?tcc?ccg?ccg?gtg?ggc?gcg?ccg?att?tac 1315

Cys?Thr?Ser?Thr?Glu?Gly?Ala?Ser?Pro?Pro?Val?Gly?Ala?Pro?Ile?Tyr

390 395 400 405

ctt?tct?gct?gcg?atc?gcc?gat?gca?aac?cca?acg?aaa?atg?ttc?gta?cca 1363

Leu?Ser?Ala?Ala?Ile?Ala?Asp?Ala?Asn?Pro?Thr?Lys?Met?Phe?Val?Pro

410 415 420

ctg?att?acg?tac?ttt?gtt?gtc?ccc?atg?att?ctg?ctt?gct?tgg?cta?gtt 1411

Leu?Ile?Thr?Tyr?Phe?Val?Val?Pro?Met?Ile?Leu?Leu?Ala?Trp?Leu?Val

425 430 435

gga?atg?gga?ttc?tta?cca?gtg?att?gtt?cct?acg?ggt?taaaggggta 1457

Gly?Met?Gly?Phe?Leu?Pro?Val?Ile?Val?Pro?Thr?Gly

440 445

aaaatgaact?caa 1470

<210>508

<211>449

<212>PRT

＜213〉Corynebacterium glutamicum

<400>508

Met?Gly?Ile?Ile?Ala?Leu?Leu?Val?Phe?Ile?Ala?Ile?Ala?Val?Ile?Leu

1 5 10 15

Asn?Val?Phe?Leu?Lys?Arg?Asp?Ile?Ser?Glu?Ala?Leu?Leu?Val?Gly?Leu

20 25 30

Val?Gly?Thr?Ala?Leu?Val?Gly?Gly?Val?Asn?Ala?Pro?Thr?Leu?Leu?Ile

35 40 45

Asp?Ala?Val?Val?Asp?Ala?Ala?Gln?Ser?Glu?Val?Thr?Phe?Ala?Gly?Met

50 55 60

Ala?Phe?Val?Phe?Met?Gly?Ile?Val?Val?Gln?Ser?Thr?Gly?Leu?Ile?Asp

65 70 75 80

Arg?Leu?Ile?Ala?Ile?Leu?Asn?Ser?Ile?Phe?Gly?Arg?Leu?Arg?Gly?Gly

85 90 95

Ala?Gly?Tyr?Val?Ser?Thr?Leu?Gly?Ser?Ala?Leu?Ile?Gly?Leu?Ile?Ala

100 105 110

Gly?Ser?Thr?Ala?Gly?Asn?Ser?Ala?Thr?Val?Gly?Ser?Val?Thr?Ile?Pro

115 120 125

Trp?Met?Lys?Lys?Thr?Gly?Trp?Thr?Ala?Glu?Arg?Ser?Ala?Thr?Leu?Val

130 135 140

Ala?Gly?Asn?Ser?Gly?Leu?Gly?Val?Ala?Leu?Pro?Pro?Asn?Ser?Thr?Met

145 150 155 160

Phe?Ile?Ile?Leu?Ala?Leu?Pro?Ala?Ala?Ala?Ala?Ser?Ser?Ala?Ser?Gln

165 170 175

Val?Tyr?Ile?Ala?Leu?Ala?Cys?Gly?Gly?Ala?Tyr?Ala?Val?Leu?Tyr?Arg

180 185 190

Leu?Ala?Val?Val?Phe?Tyr?Trp?Thr?Arg?Lys?Asp?Lys?Ile?Pro?Ala?Thr

195 200 205

Pro?Asp?Asp?Gln?Arg?Val?Ser?Phe?Gly?Glu?Ala?Met?Lys?Thr?Gly?Trp

210 215 220

Arg?Ser?Pro?Leu?Ile?Phe?Leu?Gly?Ile?Leu?Ile?Pro?Val?Ile?Leu?Thr

225 230 235 240

Ile?Gly?Pro?Leu?Ser?Glu?Trp?Leu?Lys?Thr?His?Gly?Val?Gly?Glu?Ser

245 250 255

Gly?Val?Lys?Ser?Met?Ser?Ile?Ile?Val?Trp?Val?Pro?Ile?Leu?Ile?Thr

260 265 270

Ala?Ile?Ala?Leu?Ile?Glu?Gly?Arg?Lys?Arg?Ile?Ala?Asn?Asn?Met?Ala

275 280 285

His?Phe?Arg?Val?Gln?Ile?Ser?Lys?Asp?Leu?Pro?Gln?Phe?Ala?Thr?Val

290 295 300

Gly?Ile?Ser?Leu?Phe?Ser?Ala?Leu?Ala?Ala?Ala?Asn?Ile?Met?Glu?Glu

305 310 315 320

Leu?Gly?Val?Gly?Pro?Gln?Leu?Ser?Asn?Trp?Leu?Asp?Ser?Met?Asp?Leu

325 330 335

Pro?Lys?Ser?Val?Met?Val?Ile?Ile?Val?Cys?Ile?Met?Cys?Ile?Val?Val

340 345 350

Ala?Thr?Pro?Leu?Ser?Ser?Thr?Ala?Thr?Ala?Ala?Ala?Ile?Gly?Ala?Pro

355 360 365

Ala?Val?Ala?Ala?Leu?Ala?Ala?Val?Gly?Ile?Asp?Pro?Thr?Val?Ala?Ile

370 375 380

Val?Val?Ile?Leu?Leu?Cys?Thr?Ser?Thr?Glu?Gly?Ala?Ser?Pro?Pro?Val

385 390 395 400

Gly?Ala?Pro?Ile?Tyr?Leu?Ser?Ala?Ala?Ile?Ala?Asp?Ala?Asn?Pro?Thr

405 410 415

Lys?Met?Phe?Val?Pro?Leu?Ile?Thr?Tyr?Phe?Val?Val?Pro?Met?Ile?Leu

420 425 430

Leu?Ala?Trp?Leu?Val?Gly?Met?Gly?Phe?Leu?Pro?Val?Ile?Val?Pro?Thr

435 440 445

Gly

<210>509

<211>1203

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1180)

<223>RXC00412

<400>509

cttttgacga?acaccacgtc?gcgtacgctt?cctcggggcg?ttaaactatt?tgtcttccag?60

cttttgtccc?ccgacttttg?tacgaatcga?ggacaccgtc?gtg?tca?cac?acc?gcg 115

Val?Ser?His?Thr?Ala

1 5

tcc?aca?ccg?acg?cca?gag?gaa?tac?tcc?gcg?cag?caa?ccc?agc?acc?cag 163

Ser?Thr?Pro?Thr?Pro?Glu?Glu?Tyr?Ser?Ala?Gln?Gln?Pro?Ser?Thr?Gln

10 15 20

ggc?act?cgc?gtt?gag?ttc?cgc?ggc?ata?acc?aaa?gtc?ttt?agc?aac?aat 211

Gly?Thr?Arg?Val?Glu?Phe?Arg?Gly?Ile?Thr?Lys?Val?Phe?Ser?Asn?Asn

25 30 35

aaa?tct?gct?aaa?acc?acc?gcg?ctt?gat?aat?gtc?act?ctc?acc?gta?gaa 259

Lys?Ser?Ala?Lys?Thr?Thr?Ala?Leu?Asp?Asn?Val?Thr?Leu?Thr?Val?Glu

40 45 50

ccc?ggt?gag?gta?atc?ggc?atc?atc?ggt?tac?tct?ggc?gcc?ggc?aag?tcc 307

Pro?Gly?Glu?Val?Ile?Gly?Ile?Ile?Gly?Tyr?Ser?Gly?Ala?Gly?Lys?Ser

55 60 65

act?ctt?gtc?cgc?ctc?atc?aat?ggc?ctt?gac?tcc?ccc?acg?agc?ggt?tcg 355

Thr?Leu?Val?Arg?Leu?Ile?Asn?Gly?Leu?Asp?Ser?Pro?Thr?Ser?Gly?Ser

70 75 80 85

ttg?ctg?ctc?aac?ggc?acc?gac?atc?gtc?gga?atg?ccc?gag?tct?aag?ctg 403

Leu?Leu?Leu?Asn?Gly?Thr?Asp?Ile?Val?Gly?Met?Pro?Glu?Ser?Lys?Leu

90 95 100

cgt?aaa?ctg?cgc?agt?aat?atc?ggc?atg?att?ttc?cag?cag?ttc?aac?ctg 451

Arg?Lys?Leu?Arg?Ser?Asn?Ile?Gly?Met?Ile?Phe?Gln?Gln?Phe?Asn?Leu

105 110 115

ttc?cag?tcg?cgt?act?gcg?gct?gga?aat?gtg?gag?tac?ccg?ctg?gaa?gtt 499

Phe?Gln?Ser?Arg?Thr?Ala?Ala?Gly?Asn?Val?Glu?Tyr?Pro?Leu?Glu?Val

120 125 130

gcc?aag?atg?gac?aag?gca?gct?cgt?aaa?gct?cgc?gtg?caa?gaa?atg?ctc 547

Ala?Lys?Met?Asp?Lys?Ala?Ala?Arg?Lys?Ala?Arg?Val?Gln?Glu?Met?Leu

135 140 145

gag?ttc?gtc?ggc?ctg?ggc?gac?aaa?ggc?aaa?aac?tac?ccc?gag?cag?ctg 595

Glu?Phe?Val?Gly?Leu?Gly?Asp?Lys?Gly?Lys?Asn?Tyr?Pro?Glu?Gln?Leu

150 155 160 165

tcg?ggc?ggc?cag?aag?cag?cgc?gtc?ggc?att?gcc?cgt?gca?ctg?gcc?acc 643

Ser?Gly?Gly?Gln?Lys?Gln?Arg?Val?Gly?Ile?Ala?Arg?Ala?Leu?Ala?Thr

170 175 180

aat?cca?acg?ctt?ttg?ctt?gcc?gac?gaa?gcc?acc?tcc?gct?ttg?gac?cca 691

Asn?Pro?Thr?Leu?Leu?Leu?Ala?Asp?Glu?Ala?Thr?Ser?Ala?Leu?Asp?Pro

185 190 195

gaa?acc?acc?cat?gaa?gtt?ctg?gag?ctg?ctg?cgc?aag?gta?aac?cgc?gaa 739

Glu?Thr?Thr?His?Glu?Val?Leu?Glu?Leu?Leu?Arg?Lys?Val?Asn?Arg?Glu

200 205 210

ctg?ggc?atc?acc?atc?gtt?gtg?atc?acc?cac?gaa?atg?gaa?gtt?gtg?cgt 787

Leu?Gly?Ile?Thr?Ile?Val?Val?Ile?Thr?His?Glu?Met?Glu?Val?Val?Arg

215 220 225

tcc?atc?gca?gac?aag?gtt?gct?gtg?atg?gaa?tcc?ggc?aaa?gtt?gtg?gaa 835

Ser?Ile?Ala?Asp?Lys?Val?Ala?Val?Met?Glu?Ser?Gly?Lys?Val?Val?Glu

230 235 240 245

tac?ggc?agc?gtc?tac?gag?gtg?ttc?tcc?aat?cca?caa?aca?cag?gtt?gct 883

Tyr?Gly?Ser?Val?Tyr?Glu?Val?Phe?Ser?Asn?Pro?Gln?Thr?Gln?Val?Ala

250 255 260

caa?aag?ttc?gtg?gcc?acc?gcg?ctg?cgt?aac?acc?cca?gac?caa?gtg?gaa 931

Gln?Lys?Phe?Val?Ala?Thr?Ala?Leu?Arg?Asn?Thr?Pro?Asp?Gln?Val?Glu

265 270 275

tcg?gaa?gat?ctg?ctt?agc?cat?gag?gga?cgt?ctg?ttc?acc?att?gat?ctg 979

Ser?Glu?Asp?Leu?Leu?Ser?His?Glu?Gly?Arg?Leu?Phe?Thr?Ile?Asp?Leu

280 285 290

act?gaa?acg?tcc?ggc?ttc?ttt?gca?gca?acc?gct?cgt?gct?gcc?gaa?caa 1027

Thr?Glu?Thr?Ser?Gly?Phe?Phe?Ala?Ala?Thr?Ala?Arg?Ala?Ala?Glu?Gln

295 300 305

ggt?gct?ttt?gtc?aac?atc?gtt?cac?ggt?ggc?gtg?acc?acc?ttg?caa?cgc 1075

Gly?Ala?Phe?Val?Asn?Ile?Val?His?Gly?Gly?Val?Thr?Thr?Leu?Gln?Arg

310 315 320 325

caa?tca?ttt?ggc?aaa?atg?act?gtt?cga?ctc?acc?ggc?aac?acc?gct?gcg 1123

Gln?Ser?Phe?Gly?Lys?Met?Thr?Val?Arg?Leu?Thr?Gly?Asn?Thr?Ala?Ala

330 335 340

att?gaa?gag?ttc?tat?caa?acc?ttg?acc?aag?acc?acg?acc?atc?aag?gag 1171

Ile?Glu?Glu?Phe?Tyr?Gln?Thr?Leu?Thr?Lys?Thr?Thr?Thr?Ile?Lys?Glu

345 350 355

atc?acc?cga?tgaacgagat?gatcctcgca?gct 1203

Ile?Thr?Arg

360

<210>510

<211>360

<212>PRT

＜213〉Corynebacterium glutamicum

<400>510

Val?Ser?His?Thr?Ala?Ser?Thr?Pro?Thr?Pro?Glu?Glu?Tyr?Ser?Ala?Gln

1 5 10 15

Gln?Pro?Ser?Thr?Gln?Gly?Thr?Arg?Val?Glu?Phe?Arg?Gly?Ile?Thr?Lys

20 25 30

Val?Phe?Ser?Asn?Asn?Lys?Ser?Ala?Lys?Thr?Thr?Ala?Leu?Asp?Asn?Val

35 40 45

Thr?Leu?Thr?Val?Glu?Pro?Gly?Glu?Val?Ile?Gly?Ile?Ile?Gly?Tyr?Ser

50 55 60

Gly?Ala?Gly?Lys?Ser?Thr?Leu?Val?Arg?Leu?Ile?Asn?Gly?Leu?Asp?Ser

65 70 75 80

Pro?Thr?Ser?Gly?Ser?Leu?Leu?Leu?Asn?Gly?Thr?Asp?Ile?Val?Gly?Met

85 90 95

Pro?Glu?Ser?Lys?Leu?Arg?Lys?Leu?Arg?Ser?Asn?Ile?Gly?Met?Ile?Phe

100 105 110

Gln?Gln?Phe?Asn?Leu?Phe?Gln?Ser?Arg?Thr?Ala?Ala?Gly?Asn?Val?Glu

115 120 125

Tyr?Pro?Leu?Glu?Val?Ala?Lys?Met?Asp?Lys?Ala?Ala?Arg?Lys?Ala?Arg

130 135 140

Val?Gln?Glu?Met?Leu?Glu?Phe?Val?Gly?Leu?Gly?Asp?Lys?Gly?Lys?Asn

145 150 155 160

Tyr?Pro?Glu?Gln?Leu?Ser?Gly?Gly?Gln?Lys?Gln?Arg?Val?Gly?Ile?Ala

165 170 175

Arg?Ala?Leu?Ala?Thr?Asn?Pro?Thr?Leu?Leu?Leu?Ala?Asp?Glu?Ala?Thr

180 185 190

Ser?Ala?Leu?Asp?Pro?Glu?Thr?Thr?His?Glu?Val?Leu?Glu?Leu?Leu?Arg

195 200 205

Lys?Val?Asn?Arg?Glu?Leu?Gly?Ile?Thr?Ile?Val?Val?Ile?Thr?His?Glu

210 215 220

Met?Glu?Val?Val?Arg?Ser?Ile?Ala?Asp?Lys?Val?Ala?Val?Met?Glu?Ser

225 230 235 240

Gly?Lys?Val?Val?Glu?Tyr?Gly?Ser?Val?Tyr?Glu?Val?Phe?Ser?Asn?Pro

245 250 255

Gln?Thr?Gln?Val?Ala?Gln?Lys?Phe?Val?Ala?Thr?Ala?Leu?Arg?Asn?Thr

260 265 270

Pro?Asp?Gln?Val?Glu?Ser?Glu?Asp?Leu?Leu?Ser?His?Glu?Gly?Arg?Leu

275 280 285

Phe?Thr?Ile?Asp?Leu?Thr?Glu?Thr?Ser?Gly?Phe?Phe?Ala?Ala?Thr?Ala

290 295 300

Arg?Ala?Ala?Glu?Gln?Gly?Ala?Phe?Val?Asn?Ile?Val?His?Gly?Gly?Val

305 310 315 320

Thr?Thr?Leu?Gln?Arg?Gln?Ser?Phe?Gly?Lys?Met?Thr?Val?Arg?Leu?Thr

325 330 335

Gly?Asn?Thr?Ala?Ala?Ile?Glu?Glu?Phe?Tyr?Gln?Thr?Leu?Thr?Lys?Thr

340 345 350

Thr?Thr?Ile?Lys?Glu?Ile?Thr?Arg

355 360

<210>511

<211>813

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(790)

<223>RXC00526

<400>511

ggtggagcag?gcggcggctc?cttttagtcc?tgcggcccct?tttgaccctg?cagcccctgc?60

cgtttctgcc?aagcaaaccg?tgggccaggt?gatttagcct?atg?agc?ctc?atc?gaa 115

Met?Ser?Leu?Ile?Glu

1 5

atg?cga?aat?att?gtc?aag?acc?tac?aac?att?gga?tct?gaa?ggt?gaa?ctc 163

Met?Arg?Asn?Ile?Val?Lys?Thr?Tyr?Asn?Ile?Gly?Ser?Glu?Gly?Glu?Leu

10 15 20

acc?gtg?ttg?cac?ggt?gtg?gat?ttc?cat?gtg?gac?cgt?ggc?gaa?ttc?gtg 211

Thr?Val?Leu?His?Gly?Val?Asp?Phe?His?Val?Asp?Arg?Gly?Glu?Phe?Val

25 30 35

tcg?gtt?gtg?ggt?acg?tcc?ggc?tca?ggt?aaa?tca?acg?atg?atg?aac?atc 259

Ser?Val?Val?Gly?Thr?Ser?Gly?Ser?Gly?Lys?Ser?Thr?Met?Met?Asn?Ile

40 45 50

att?ggg?ttg?ttg?gat?aag?cca?act?gat?ggc?acg?tac?acc?ttg?gat?ggc 307

Ile?Gly?Leu?Leu?Asp?Lys?Pro?Thr?Asp?Gly?Thr?Tyr?Thr?Leu?Asp?Gly

55 60 65

gtg?gat?gtg?ttg?gat?atc?agc?gat?gat?gct?ttg?gcg?agc?cac?cgc?gct 355

Val?Asp?Val?Leu?Asp?Ile?Ser?Asp?Asp?Ala?Leu?Ala?Ser?His?Arg?Ala

70 75 80 85

aaa?tcg?att?ggt?ttt?gtg?ttt?cag?aac?ttc?aat?ctg?att?ggc?cgg?atc 403

Lys?Ser?Ile?Gly?Phe?Val?Phe?Gln?Asn?Phe?Asn?Leu?Ile?Gly?Arg?Ile

90 95 100

gat?gcg?ttg?aag?aat?gtg?gaa?atg?ccc?atg?atg?tat?gcg?ggc?att?ccg 451

Asp?Ala?Leu?Lys?Asn?Val?Glu?Met?Pro?Met?Met?Tyr?Ala?Gly?Ile?Pro

105 110 115

gct?aag?cag?cgg?aga?agt?cgt?gcg?gtt?gaa?tta?ttg?gaa?atg?gtc?ggg 499

Ala?Lys?Gln?Arg?Arg?Ser?Arg?Ala?Val?Glu?Leu?Leu?Glu?Met?Val?Gly

120 125 130

atg?ggt?gag?cgt?ctc?aac?cat?gag?ccc?aat?gag?ctt?tcg?ggt?ggt?cag 547

Met?Gly?Glu?Arg?Leu?Asn?His?Glu?Pro?Asn?Glu?Leu?Ser?Gly?Gly?Gln

135 140 145

aag?cag?cgc?gtg?gcc?att?gct?cgc?gcg?ttg?gcg?aac?gat?cct?gag?atc 595

Lys?Gln?Arg?Val?Ala?Ile?Ala?Arg?Ala?Leu?Ala?Asn?Asp?Pro?Glu?Ile

150 155 160 165

att?ctt?gct?gat?gaa?cca?act?ggt?gcg?ttg?gat?tct?gca?acg?ggc?cgg 643

Ile?Leu?Ala?Asp?Glu?Pro?Thr?Gly?Ala?Leu?Asp?Ser?Ala?Thr?Gly?Arg

170 175 180

atg?gtg?atg?gat?att?ttc?cac?cag?ctc?aac?aag?gag?cag?ggc?aaa?acc 691

Met?Val?Met?Asp?Ile?Phe?His?Gln?Leu?Asn?Lys?Glu?Gln?Gly?Lys?Thr

185 190 195

atc?gtg?ttt?att?act?cac?aac?cct?gag?ctt?gct?gat?gaa?tct?gat?cgg 739

Ile?Val?Phe?Ile?Thr?His?Asn?Pro?Glu?Leu?Ala?Asp?Glu?Ser?Asp?Arg

200 205 210

gtg?gtc?acc?atg?gtt?gac?ggg?cgc?atc?att?ggg?tct?gag?gtg?aaa?cac 787

Val?Val?Thr?Met?Val?Asp?Gly?Arg?Ile?Ile?Gly?Ser?Glu?Val?Lys?His

215 220 225

tca?tgagccttgc?agaatcaatt?ctt 813

Ser

230

<210>512

<211>230

<212>PRT

＜213〉Corynebacterium glutamicum

<400>512

Met?Ser?Leu?Ile?Glu?Met?Arg?Asn?Ile?Val?Lys?Thr?Tyr?Asn?Ile?Gly

1 5 10 15

Ser?Glu?Gly?Glu?Leu?Thr?Val?Leu?His?Gly?Val?Asp?Phe?His?Val?Asp

20 25 30

Arg?Gly?Glu?Phe?Val?Ser?Val?Val?Gly?Thr?Ser?Gly?Ser?Gly?Lys?Ser

35 40 45

Thr?Met?Met?Asn?Ile?Ile?Gly?Leu?Leu?Asp?Lys?Pro?Thr?Asp?Gly?Thr

50 55 60

Tyr?Thr?Leu?Asp?Gly?Val?Asp?Val?Leu?Asp?Ile?Ser?Asp?Asp?Ala?Leu

65 70 75 80

Ala?Ser?His?Arg?Ala?Lys?Ser?Ile?Gly?Phe?Val?Phe?Gln?Asn?Phe?Asn

85 90 95

Leu?Ile?Gly?Arg?Ile?Asp?Ala?Leu?Lys?Asn?Val?Glu?Met?Pro?Met?Met

100 105 110

Tyr?Ala?Gly?Ile?Pro?Ala?Lys?Gln?Arg?Arg?Ser?Arg?Ala?Val?Glu?Leu

115 120 125

Leu?Glu?Met?Val?Gly?Met?Gly?Glu?Arg?Leu?Asn?His?Glu?Pro?Asn?Glu

130 135 140

Leu?Ser?Gly?Gly?Gln?Lys?Gln?Arg?Val?Ala?Ile?Ala?Arg?Ala?Leu?Ala

145 150 155 160

Asn?Asp?Pro?Glu?Ile?Ile?Leu?Ala?Asp?Glu?Pro?Thr?Gly?Ala?Leu?Asp

165 170 175

Ser?Ala?Thr?Gly?Arg?Met?Val?Met?Asp?Ile?Phe?His?Gln?Leu?Asn?Lys

180 185 190

Glu?Gln?Gly?Lys?Thr?Ile?Val?Phe?Ile?Thr?His?Asn?Pro?Glu?Leu?Ala

195 200 205

Asp?Glu?Ser?Asp?Arg?Val?Val?Thr?Met?Val?Asp?Gly?Arg?Ile?Ile?Gly

210 215 220

Ser?Glu?Val?Lys?His?Ser

225 230

<210>513

<211>1185

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1162)

<223>RXC01004

<400>513

ccggacgctg?gatcgcacga?gtaacggtca?tggaagatcg?acgcatcgac?aaagccgttc?60

tcacccccat?cacccatgaa?gaagcaaagg?agtacgaaaa?gtg?agt?att?tgg?gca 115

Val?Ser?Ile?Trp?Ala

1 5

act?gtc?ctt?cta?att?atc?gtc?ctt?ctt?tcc?gcc?aac?gcc?ttc?ttc?gtg 163

Thr?Val?Leu?Leu?Ile?Ile?Val?Leu?Leu?Ser?Ala?Asn?Ala?Phe?Phe?Val

10 15 20

gcc?gcg?gag?ttc?gca?ctg?att?tcc?tcg?cgc?cgg?gac?cgc?ctg?gat?tcc 211

Ala?Ala?Glu?Phe?Ala?Leu?Ile?Ser?Ser?Arg?Arg?Asp?Arg?Leu?Asp?Ser

25 30 35

ctg?gta?tcc?cag?ggt?aaa?aag?gga?gct?gaa?aag?gtt?ctc?tac?gca?acc 259

Leu?Val?Ser?Gln?Gly?Lys?Lys?Gly?Ala?Glu?Lys?Val?Leu?Tyr?Ala?Thr

40 45 50

gag?cac?ctc?tcc?atc?atg?ttg?gcg?ggc?gct?cag?ttc?ggt?att?acg?gtc 307

Glu?His?Leu?Ser?Ile?Met?Leu?Ala?Gly?Ala?Gln?Phe?Gly?Ile?Thr?Val

55 60 65

tgt?tct?ctg?att?ctg?ggt?aaa?gtc?gca?gaa?cct?gcg?atc?gcc?cac?ttc 355

Cys?Ser?Leu?Ile?Leu?Gly?Lys?Val?Ala?Glu?Pro?Ala?Ile?Ala?His?Phe

70 75 80 85

att?gag?gtg?cct?ttc?acc?tcc?tgg?ggt?gtt?cca?aat?gat?ttg?atc?cac 403

Ile?Glu?Val?Pro?Phe?Thr?Ser?Trp?Gly?Val?Pro?Asn?Asp?Leu?Ile?His

90 95 100

cca?att?tcc?ttc?gtc?atc?gca?ctg?gcg?atc?atc?acc?tgg?ttg?cac?att 451

Pro?Ile?Ser?Phe?Val?Ile?Ala?Leu?Ala?Ile?Ile?Thr?Trp?Leu?His?Ile

105 110 115

ctc?ttt?ggt?gaa?atg?gtg?cca?aag?aac?atc?gct?att?gct?ggc?cct?gaa 499

Leu?Phe?Gly?Glu?Met?Val?Pro?Lys?Asn?Ile?Ala?Ile?Ala?Gly?Pro?Glu

120 125 130

acc?tta?ggc?atg?tgg?ctt?gct?cca?gtg?ctc?att?gcg?ttt?gtg?aag?att 547

Thr?Leu?Gly?Met?Trp?Leu?Ala?Pro?Val?Leu?Ile?Ala?Phe?Val?Lys?Ile

135 140 145

acc?cgc?ccg?ttg?atc?gag?ttc?atg?aac?tgg?atc?gcc?cgt?ctg?acc?ctt 595

Thr?Arg?Pro?Leu?Ile?Glu?Phe?Met?Asn?Trp?Ile?Ala?Arg?Leu?Thr?Leu

150 155 160 165

cgc?gcc?ttt?ggt?gtg?gag?caa?aaa?aac?gag?ctg?gat?tcc?acc?gtg?gac 643

Arg?Ala?Phe?Gly?Val?Glu?Gln?Lys?Asn?Glu?Leu?Asp?Ser?Thr?Val?Asp

170 175 180

cca?gag?cag?ctg?gca?tca?atg?att?tcc?gag?tcc?cgt?tcc?gaa?ggc?ctc 691

Pro?Glu?Gln?Leu?Ala?Ser?Met?Ile?Ser?Glu?Ser?Arg?Ser?Glu?Gly?Leu

185 190 195

ctt?gat?gct?gaa?gag?cac?gcc?cgc?ctg?tcc?aag?gcg?ctg?cgc?tct?gag 739

Leu?Asp?Ala?Glu?Glu?His?Ala?Arg?Leu?Ser?Lys?Ala?Leu?Arg?Ser?Glu

200 205 210

cag?cgt?tcc?atc?aag?gaa?ctg?gtg?att?aag?gat?gag?gac?gtg?cgc?acg 787

Gln?Arg?Ser?Ile?Lys?Glu?Leu?Val?Ile?Lys?Asp?Glu?Asp?Val?Arg?Thr

215 220 225

ctg?gcg?ttc?ggt?aaa?tct?ggc?ccg?acc?ttg?cac?cag?ttg?gag?gaa?gca 835

Leu?Ala?Phe?Gly?Lys?Ser?Gly?Pro?Thr?Leu?His?Gln?Leu?Glu?Glu?Ala

230 235 240 245

gtc?cgc?gag?acc?ggt?ttc?tcc?cgc?ttc?cct?gtc?acc?ggc?cgc?gat?gga 883

Val?Arg?Glu?Thr?Gly?Phe?Ser?Arg?Phe?Pro?Val?Thr?Gly?Arg?Asp?Gly

250 255 260

tcc?tac?ttg?ggt?tat?atc?cac?atc?aag?gat?att?ttg?cct?cgt?ctg?gct 931

Ser?Tyr?Leu?Gly?Tyr?Ile?His?Ile?Lys?Asp?Ile?Leu?Pro?Arg?Leu?Ala

265 270 275

gat?cct?gag?atg?gat?ccc?tcc?gag?acc?att?ccg?cgt?tct?gca?ctg?cgc 979

Asp?Pro?Glu?Met?Asp?Pro?Ser?Glu?Thr?Ile?Pro?Arg?Ser?Ala?Leu?Arg

280 285 290

cct?ttg?agc?aat?gtg?gat?gcc?gac?ggc?ctc?atg?gat?gac?gtc?ttg?gat 1027

Pro?Leu?Ser?Asn?Val?Asp?Ala?Asp?Gly?Leu?Met?Asp?Asp?Val?Leu?Asp

295 300 305

ttt?atg?cac?tac?cgc?tcc?gcg?cac?atg?gct?cag?gtt?cgc?ctc?aaa?ggt 1075

Phe?Met?His?Tyr?Arg?Ser?Ala?His?Met?Ala?Gln?Val?Arg?Leu?Lys?Gly

310 315 320 325

gag?ctt?ctc?ggc?gtg?att?acg?ctg?gag?gat?ctc?atc?gaa?gaa?tac?gtg 1123

Glu?Leu?Leu?Gly?Val?Ile?Thr?Leu?Glu?Asp?Leu?Ile?Glu?Glu?Tyr?Val

330 335 340

ggc?acc?gtc?aac?gat?tgg?act?cac?gaa?agc?tcc?gac?gac?tagaaatagt 1172

Gly?Thr?Val?Asn?Asp?Trp?Thr?His?Glu?Ser?Ser?Asp?Asp

345 350

aactgtgttg?gac 1185

<210>514

<211>354

<212>PRT

＜213〉Corynebacterium glutamicum

<400>514

Val?Ser?Ile?Trp?Ala?Thr?Val?Leu?Leu?Ile?Ile?Val?Leu?Leu?Ser?Ala

1 5 10 15

Asn?Ala?Phe?Phe?Val?Ala?Ala?Glu?Phe?Ala?Leu?Ile?Ser?Ser?Arg?Arg

20 25 30

Asp?Arg?Leu?Asp?Ser?Leu?Val?Ser?Gln?Gly?Lys?Lys?Gly?Ala?Glu?Lys

35 40 45

Val?Leu?Tyr?Ala?Thr?Glu?His?Leu?Ser?Ile?Met?Leu?Ala?Gly?Ala?Gln

50 55 60

Phe?Gly?Ile?Thr?Val?Cys?Ser?Leu?Ile?Leu?Gly?Lys?Val?Ala?Glu?Pro

65 70 75 80

Ala?Ile?Ala?His?Phe?Ile?Glu?Val?Pro?Phe?Thr?Ser?Trp?Gly?Val?Pro

85 90 95

Asn?Asp?Leu?Ile?His?Pro?Ile?Ser?Phe?Val?Ile?Ala?Leu?Ala?Ile?Ile

100 105 110

Thr?Trp?Leu?His?Ile?Leu?Phe?Gly?Glu?Met?Val?Pro?Lys?Asn?Ile?Ala

115 120 125

Ile?Ala?Gly?Pro?Glu?Thr?Leu?Gly?Met?Trp?Leu?Ala?Pro?Val?Leu?Ile

130 135 140

Ala?Phe?Val?Lys?Ile?Thr?Arg?Pro?Leu?Ile?Glu?Phe?Met?Asn?Trp?Ile

145 150 155 160

Ala?Arg?Leu?Thr?Leu?Arg?Ala?Phe?Gly?Val?Glu?Gln?Lys?Asn?Glu?Leu

165 170 175

Asp?Ser?Thr?Val?Asp?Pro?Glu?Gln?Leu?Ala?Ser?Met?Ile?Ser?Glu?Ser

180 185 190

Arg?Ser?Glu?Gly?Leu?Leu?Asp?Ala?Glu?Glu?His?Ala?Arg?Leu?Ser?Lys

195 200 205

Ala?Leu?Arg?Ser?Glu?Gln?Arg?Ser?Ile?Lys?Glu?Leu?Val?Ile?Lys?Asp

210 215 220

Glu?Asp?Val?Arg?Thr?Leu?Ala?Phe?Gly?Lys?Ser?Gly?Pro?Thr?Leu?His

225 230 235 240

Gln?Leu?Glu?Glu?Ala?Val?Arg?Glu?Thr?Gly?Phe?Ser?Arg?Phe?Pro?Val

245 250 255

Thr?Gly?Arg?Asp?Gly?Ser?Tyr?Leu?Gly?Tyr?Ile?His?Ile?Lys?Asp?Ile

260 265 270

Leu?Pro?Arg?Leu?Ala?Asp?Pro?Glu?Met?Asp?Pro?Ser?Glu?Thr?Ile?Pro

275 280 285

Arg?Ser?Ala?Leu?Arg?Pro?Leu?Ser?Asn?Val?Asp?Ala?Asp?Gly?Leu?Met

290 295 300

Asp?Asp?Val?Leu?Asp?Phe?Met?His?Tyr?Arg?Ser?Ala?His?Met?Ala?Gln

305 310 315 320

Val?Arg?Leu?Lys?Gly?Glu?Leu?Leu?Gly?Val?Ile?Thr?Leu?Glu?Asp?Leu

325 330 335

Ile?Glu?Glu?Tyr?Val?Gly?Thr?Val?Asn?Asp?Trp?Thr?His?Glu?Ser?Ser

340 345 350

Asp?Asp

<210>515

<211>732

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(709)

<223>RXC01017

<400>515

gaaatttgag?ggggcgctac?ccttagaagg?tgcgcaatga?caccacgata?gttcgcgcct?60

agtgtggatt?gctagaaaac?tttaagaaag?aggaaataat?atg?gct?caa?aaa?gta 115

Met?Ala?Gln?Lys?Val

1 5

acc?ttc?tgg?ttc?gat?acc?acc?tgc?cca?ttc?tgc?tgg?gtc?acc?tcc?cgc 163

Thr?Phe?Trp?Phe?Asp?Thr?Thr?Cys?Pro?Phe?Cys?Trp?Val?Thr?Ser?Arg

10 15 20

tgg?att?aag?gaa?gtc?gaa?caa?gtc?cgc?gat?att?gaa?atc?cag?tgg?gtt 211

Trp?Ile?Lys?Glu?Val?Glu?Gln?Val?Arg?Asp?Ile?Glu?Ile?Gln?Trp?Val

25 30 35

cca?atg?agc?ctc?gct?gtc?cta?aac?gaa?ggc?cgt?gat?ctc?cca?gag?gat 259

Pro?Met?Ser?Leu?Ala?Val?Leu?Asn?Glu?Gly?Arg?Asp?Leu?Pro?Glu?Asp

40 45 50

tac?aag?gag?cgc?atg?aag?gct?gca?tgg?gga?cca?gca?cgc?gtt?ttc?gca 307

Tyr?Lys?Glu?Arg?Met?Lys?Ala?Ala?Trp?Gly?Pro?Ala?Arg?Val?Phe?Ala

55 60 65

gct?gtc?gcc?acc?gac?cat?gct?gac?aag?ctc?ggc?gac?ctg?tac?acc?gca 355

Ala?Val?Ala?Thr?Asp?His?Ala?Asp?Lys?Leu?Gly?Asp?Leu?Tyr?Thr?Ala

70 75 80 85

atg?ggt?acc?cgc?atc?cac?aac?gac?ggt?cgc?gga?cca?atc?gaa?ggt?tcc 403

Met?Gly?Thr?Arg?Ile?His?Asn?Asp?Gly?Arg?Gly?Pro?Ile?Glu?Gly?Ser

90 95 100

ttc?aat?gat?gtc?atc?gca?gag?gca?ctt?gaa?gag?gtc?ggc?cta?gac?gct 451

Phe?Asn?Asp?Val?Ile?Ala?Glu?Ala?Leu?Glu?Glu?Val?Gly?Leu?Asp?Ala

105 110 115

gca?ctt?ggt?gaa?gtt?gca?gac?acc?acc?gaa?tgg?gac?gac?gca?ctt?cgc 499

Ala?Leu?Gly?Glu?Val?Ala?Asp?Thr?Thr?Glu?Trp?Asp?Asp?Ala?Leu?Arg

120 125 130

gca?ttc?cac?cag?acc?gca?atg?gac?gag?gtc?ggc?aac?gat?gtc?gga?acc 547

Ala?Phe?His?Gln?Thr?Ala?Met?Asp?Glu?Val?Gly?Asn?Asp?Val?Gly?Thr

135 140 145

cca?gtg?gtc?aag?ctc?ggc?gac?acc?gct?ttc?ttc?ggc?cca?gtg?ctc?acc 595

Pro?Val?Val?Lys?Leu?Gly?Asp?Thr?Ala?Phe?Phe?Gly?Pro?Val?Leu?Thr

150 155 160 165

cgc?atc?cca?cgc?ggc?gag?gaa?gca?gga?gag?atc?ttc?gac?gct?tcc?ttc 643

Arg?Ile?Pro?Arg?Gly?Glu?Glu?Ala?Gly?Glu?Ile?Phe?Asp?Ala?Ser?Phe

170 175 180

aag?ctc?gca?agc?tat?ccc?cac?ttc?ttt?gaa?atc?aag?cgc?agc?cgc?act 691

Lys?Leu?Ala?Ser?Tyr?Pro?His?Phe?Phe?Glu?Ile?Lys?Arg?Ser?Arg?Thr

185 190 195

gag?aac?cca?cag?ttc?gac?taattaacgc?tgtctctgct?tat 732

Glu?Asn?Pro?Gln?Phe?Asp

200

<210>516

<211>203

<212>PRT

＜213〉Corynebacterium glutamicum

<400>516

Met?Ala?Gln?Lys?Val?Thr?Phe?Trp?Phe?Asp?Thr?Thr?Cys?Pro?Phe?Cys

1 5 10 15

Trp?Val?Thr?Ser?Arg?Trp?Ile?Lys?Glu?Val?Glu?Gln?Val?Arg?Asp?Ile

20 25 30

Glu?Ile?Gln?Trp?Val?Pro?Met?Ser?Leu?Ala?Val?Leu?Asn?Glu?Gly?Arg

35 40 45

Asp?Leu?Pro?Glu?Asp?Tyr?Lys?Glu?Arg?Met?Lys?Ala?Ala?Trp?Gly?Pro

50 55 60

Ala?Arg?Val?Phe?Ala?Ala?Val?Ala?Thr?Asp?His?Ala?Asp?Lys?Leu?Gly

65 70 75 80

Asp?Leu?Tyr?Thr?Ala?Met?Gly?Thr?Arg?Ile?His?Asn?Asp?Gly?Arg?Gly

85 90 95

Pro?Ile?Glu?Gly?Ser?Phe?Asn?Asp?Val?Ile?Ala?Glu?Ala?Leu?Glu?Glu

100 105 110

Val?Gly?Leu?Asp?Ala?Ala?Leu?Gly?Glu?Val?Ala?Asp?Thr?Thr?Glu?Trp

115 120 125

Asp?Asp?Ala?Leu?Arg?Ala?Phe?His?Gln?Thr?Ala?Met?Asp?Glu?Val?Gly

130 135 140

Asn?Asp?Val?Gly?Thr?Pro?Val?Val?Lys?Leu?Gly?Asp?Thr?Ala?Phe?Phe

145 150 155 160

Gly?Pro?Val?Leu?Thr?Arg?Ile?Pro?Arg?Gly?Glu?Glu?Ala?Gly?Glu?Ile

165 170 175

Phe?Asp?Ala?Ser?Phe?Lys?Leu?Ala?Ser?Tyr?Pro?His?Phe?Phe?Glu?Ile

180 185 190

Lys?Arg?Ser?Arg?Thr?Glu?Asn?Pro?Gln?Phe?Asp

195 200

<210>517

<211>622

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(622)

<223>RXC01021

<400>517

cgagaggctt?ttttggctct?aagcctttta?gtcgtgcgaa?cgaaatctta?agcagcctcg?60

gtgccaccga?gatcgattgg?tcgctgtaag?gtatctgatt?atg?tcc?agt?tcc?gaa 115

Met?Ser?Ser?Ser?Glu

1 5

agc?tcg?cgt?tcc?gaa?ggc?tcg?cag?cca?gca?ccg?tct?gta?cag?cct?gaa 163

Ser?Ser?Arg?Ser?Glu?Gly?Ser?Gln?Pro?Ala?Pro?Ser?Val?Gln?Pro?Glu

10 15 20

cgc?cgt?gct?gat?tca?acg?ggg?gct?cct?gcg?gca?gct?tcc?aag?gaa?gct 211

Arg?Arg?Ala?Asp?Ser?Thr?Gly?Ala?Pro?Ala?Ala?Ala?Ser?Lys?Glu?Ala

25 30 35

tcc?caa?caa?atg?gac?gct?gcc?gga?gtt?ctt?gag?tgg?gcc?agg?acc?gct 259

Ser?Gln?Gln?Met?Asp?Ala?Ala?Gly?Val?Leu?Glu?Trp?Ala?Arg?Thr?Ala

40 45 50

gtc?gag?cag?ctt?tct?gaa?cgt?cgt?gca?gag?atc?aat?gca?ctg?aat?gtc 307

Val?Glu?Gln?Leu?Ser?Glu?Arg?Arg?Ala?Glu?Ile?Asn?Ala?Leu?Asn?Val

55 60 65

ttt?cct?gtt?cca?gat?gca?gac?act?gga?tca?aac?atg?acc?tac?acc?atg 355

Phe?Pro?Val?Pro?Asp?Ala?Asp?Thr?Gly?Ser?Asn?Met?Thr?Tyr?Thr?Met

70 75 80 85

aca?gct?gcg?ttg?gat?gaa?gcg?ctg?aaa?ctg?ggg?gag?ttg?ggt?gat?gtc 403

Thr?Ala?Ala?Leu?Asp?Glu?Ala?Leu?Lys?Leu?Gly?Glu?Leu?Gly?Asp?Val

90 95 100

gca?agg?att?act?gag?gct?ttg?gct?gtt?ggt?tct?gtg?cgt?gga?gcc?cga 451

Ala?Arg?Ile?Thr?Glu?Ala?Leu?Ala?Val?Gly?Ser?Val?Arg?Gly?Ala?Arg

105 110 115

gga?aat?tct?gga?gta?gtc?ctt?agt?cag?gtc?ctt?cgc?gct?att?gct?cag 499

Gly?Asn?Ser?Gly?Val?Val?Leu?Ser?Gln?Val?Leu?Arg?Ala?Ile?Ala?Gln

120 125 130

gca?gct?gct?gac?ggg?gtt?att?gat?ggc?cac?aca?atc?caa?gaa?gcg?cta 547

Ala?Ala?Ala?Asp?Gly?Val?Ile?Asp?GIy?His?Thr?Ile?Gln?Glu?Ala?Leu

135 140 145

tcc?att?gct?cgc?tcc?cta?gtt?gat?cgc?gca?att?aca?gat?cct?gtg?gag 595

Ser?Ile?Ala?Arg?Ser?Leu?Val?Asp?Arg?Ala?Ile?Thr?Asp?Pro?Val?Glu

150 155 160 165

ggc?act?gtt?gtc?act?gtg?ttg?cgt?tct 622

Gly?Thr?Val?Val?Thr?Val?Leu?Arg?Ser

170

<210>518

<211>174

<212>PRT

＜213〉Corynebacterium glutamicum

<400>518

Met?Ser?Ser?Ser?Glu?Ser?Ser?Arg?Ser?Glu?Gly?Ser?Gln?Pro?Ala?Pro

1 5 10 15

Ser?Val?Gln?Pro?Glu?Arg?Arg?Ala?Asp?Ser?Thr?Gly?Ala?Pro?Ala?Ala

20 25 30

Ala?Ser?Lys?Glu?Ala?Ser?Gln?Gln?Met?Asp?Ala?Ala?Gly?Val?Leu?Glu

35 40 45

Trp?Ala?Arg?Thr?Ala?Val?Glu?Gln?Leu?Ser?Glu?Arg?Arg?Ala?Glu?Ile

50 55 60

Asn?Ala?Leu?Asn?Val?Phe?Pro?Val?Pro?Asp?Ala?Asp?Thr?Gly?Ser?Asn

65 70 75 80

Met?Thr?Tyr?Thr?Met?Thr?Ala?Ala?Leu?Asp?Glu?Ala?Leu?Lys?Leu?Gly

85 90 95

Glu?Leu?Gly?Asp?Val?Ala?Arg?Ile?Thr?Glu?Ala?Leu?Ala?Val?Gly?Ser

100 105 110

Val?Arg?Gly?Ala?Arg?Gly?Asn?Ser?Gly?Val?Val?Leu?Ser?Gln?Val?Leu

115 120 125

Arg?Ala?Ile?Ala?Gln?Ala?Ala?Ala?Asp?Gly?Val?Ile?Asp?Gly?His?Thr

130 135 140

Ile?Gln?Glu?Ala?Leu?Ser?Ile?Ala?Arg?Ser?Leu?Val?Asp?Arg?Ala?Ile

145 150 155 160

Thr?Asp?Pro?Val?Glu?Gly?Thr?Val?Val?Thr?Val?Leu?Arg?Ser

165 170

<210>519

<21l>1047

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1024)

<223>RXC01212

<400>519

tttagaagcc?acatgacata?tgtcatgaaa?attatgtgca?aagtgcagta?atactcctga?60

catatggctc?taccagcgcc?aatgcgaagt?aggaagaatt?atg?cct?atg?aca?acg 115

Met?Pro?Met?Thr?Thr

1 5

aca?cca?gca?atc?gac?gta?aca?gac?ctc?gtg?aga?acc?tac?ggc?gac?tac 163

Thr?Pro?Ala?Ile?Asp?Val?Thr?Asp?Leu?Val?Arg?Thr?Tyr?Gly?Asp?Tyr

10 15 20

acc?gca?gtc?aag?ggc?ctg?aat?ttc?cat?gta?cag?cgc?ggt?gaa?gta?ttt 211

Thr?Ala?Val?Lys?Gly?Leu?Asn?Phe?His?Val?Gln?Arg?Gly?Glu?Val?Phe

25 30 35

ggt?ctg?ctc?ggc?acc?aac?ggg?gcc?ggc?aaa?acc?tcc?acc?ttg?gaa?gtc 259

Gly?Leu?Leu?Gly?Thr?Asn?Gly?Ala?Gly?Lys?Thr?Ser?Thr?Leu?Glu?Val

40 45 50

atc?gaa?gga?ctt?tcc?gca?ccc?agc?tcc?ggc?acc?gtg?cgc?atc?tcc?ggg 307

Ile?Glu?Gly?Leu?Ser?Ala?Pro?Ser?Ser?Gly?Thr?Val?Arg?Ile?Ser?Gly

55 60 65

ctt?gac?ccc?gtt?gcc?gac?cgc?gcg?atc?ctg?cgc?ccc?gag?ctc?ggc?atc 355

Leu?Asp?Pro?Val?Ala?Asp?Arg?Ala?Ile?Leu?Arg?Pro?Glu?Leu?Gly?Ile

70 75 80 85

atg?ctg?caa?tca?ggc?ggc?ctg?cca?tca?cag?ctc?acc?gtc?gcc?gaa?acc 403

Met?Leu?Gln?Ser?Gly?Gly?Leu?Pro?Ser?Gln?Leu?Thr?Val?Ala?Glu?Thr

90 95 100

atg?gac?atg?tgg?cac?ggc?acc?tgc?acg?tat?ccg?cgc?gcc?att?aaa?gat 451

Met?Asp?Met?Trp?His?Gly?Thr?Cys?Thr?Tyr?Pro?Arg?Ala?Ile?Lys?Asp

105 110 115

gtg?ctt?gcc?gac?gtc?gac?ctc?cta?cac?cgc?gaa?aac?gtc?aag?gtc?ggc 499

Val?Leu?Ala?Asp?Val?Asp?Leu?Leu?His?Arg?Glu?Asn?Val?Lys?Val?Gly

120 125 130

gcg?ctt?tcc?gga?ggc?gaa?caa?cga?cgc?ctt?gat?ttg?gcc?tgc?gca?ctg 547

Ala?Leu?Ser?Gly?Gly?Glu?Gln?Arg?Arg?Leu?Asp?Leu?Ala?Cys?Ala?Leu

135 140 145

ctt?ggc?gac?ccc?tca?att?ttg?ttc?ctc?gac?gaa?ccc?acc?acc?ggc?ctc 595

Leu?Gly?Asp?Pro?Ser?Ile?Leu?Phe?Leu?Asp?Glu?Pro?Thr?Thr?Gly?Leu

150 155 160 165

gac?cca?gaa?tct?agg?cgc?cac?acc?tgg?caa?ctc?ctg?ctg?gac?ctg?aaa 643

Asp?Pro?Glu?Ser?Arg?Arg?His?Thr?Trp?Gln?Leu?Leu?Leu?Asp?Leu?Lys

170 175 180

cag?cgc?ggc?gtc?acc?atg?atg?ctg?acc?acc?cac?tac?ctg?gag?gaa?gcc 691

Gln?Arg?Gly?Val?Thr?Met?Met?Leu?Thr?Thr?His?Tyr?Leu?Glu?Glu?Ala

185 190 195

gaa?ttc?ctc?tgc?gac?cgg?att?gcc?atc?atg?aac?gcc?ggt?gag?atc?gca 739

Glu?Phe?Leu?Cys?Asp?Arg?Ile?Ala?Ile?Met?Asn?Ala?Gly?Glu?Ile?Ala

200 205 210

gtg?gaa?ggc?acc?ttg?gat?gaa?ctg?gtg?gcc?cgc?gag?aag?tcg?atc?atc 787

Val?Glu?Gly?Thr?Leu?Asp?Glu?Leu?Val?Ala?Arg?Glu?Lys?Ser?Ile?Ile

215 220 225

agt?ttc?gtg?ctg?cgt?ggc?ggg?cag?gtg?gag?ttg?ccg?gtc?ttg?agt?ggg 835

Ser?Phe?Val?Leu?Arg?Gly?Gly?Gln?Val?Glu?Leu?Pro?Val?Leu?Ser?Gly

230 235 240 245

gct?gaa?atc?atc?cgc?gac?aac?aac?cac?gtc?cgc?atc?gcc?acc?acc?acc 883

Ala?Glu?Ile?Ile?Arg?Asp?Asn?Asn?His?Val?Arg?Ile?Ala?Thr?Thr?Thr

250 255 260

ctg?cag?cag?cac?acc?tta?gaa?ata?ctt?acc?tgg?gct?gca?gag?acc?ggg 931

Leu?Gln?Gln?His?Thr?Leu?Glu?Ile?Leu?Thr?Trp?Ala?Ala?Glu?Thr?Gly

265 270 275

atc?gcg?ctg?gaa?ggc?ttc?gct?gca?aaa?ccc?gcc?acc?ttg?gaa?tcc?gta 979

Ile?Ala?Leu?Glu?Gly?Phe?Ala?Ala?Lys?Pro?Ala?Thr?Leu?Glu?Ser?Val

280 285 290

ttc?atg?gac?atc?gcc?tca?ctc?gag?aac?acc?tcg?ctg?caa?acc?gcc 1024

Phe?Met?Asp?Ile?Ala?Ser?Leu?Glu?Asn?Thr?Ser?Leu?Gln?Thr?Ala

295 300 305

tagaatcttt?aaggagacca?caa 1047

<210>520

<211>308

<212>PRT

＜213〉Corynebacterium glutamicum

<400>520

Met?Pro?Met?Thr?Thr?Thr?Pro?Ala?Ile?Asp?Val?Thr?Asp?Leu?Val?Arg

1 5 10 15

Thr?Tyr?Gly?Asp?Tyr?Thr?Ala?Val?Lys?Gly?Leu?Asn?Phe?His?Val?Gln

20 25 30

Arg?Gly?Glu?Val?Phe?Gly?Leu?Leu?Gly?Thr?Asn?Gly?Ala?Gly?Lys?Thr

35 40 45

Ser?Thr?Leu?Glu?Val?Ile?Glu?Gly?Leu?Ser?Ala?Pro?Ser?Ser?Gly?Thr

50 55 60

Val?Arg?Ile?Ser?Gly?Leu?Asp?Pro?Val?Ala?Asp?Arg?Ala?Ile?Leu?Arg

65 70 75 80

Pro?Glu?Leu?Gly?Ile?Met?Leu?Gln?Ser?Gly?Gly?Leu?Pro?Ser?Gln?Leu

85 90 95

Thr?Val?Ala?Glu?Thr?Met?Asp?Met?Trp?His?Gly?Thr?Cys?Thr?Tyr?Pro

100 105 110

Arg?Ala?Ile?Lys?Asp?Val?Leu?Ala?Asp?Val?Asp?Leu?Leu?His?Arg?Glu

115 120 125

Asn?Val?Lys?Val?Gly?Ala?Leu?Ser?Gly?Gly?Glu?Gln?Arg?Arg?Leu?Asp

130 135 140

Leu?Ala?Cys?Ala?Leu?Leu?Gly?Asp?Pro?Ser?Ile?Leu?Phe?Leu?Asp?Glu

145 150 155 160

Pro?Thr?Thr?Gly?Leu?Asp?Pro?Glu?Ser?Arg?Arg?His?Thr?Trp?Gln?Leu

165 170 175

Leu?Leu?Asp?Leu?Lys?Gln?Arg?Gly?Val?Thr?Met?Met?Leu?Thr?Thr?His

180 185 190

Tyr?Leu?Glu?Glu?Ala?Glu?Phe?Leu?Cys?Asp?Arg?Ile?Ala?Ile?Met?Asn

195 200 205

Ala?Gly?Glu?Ile?Ala?Val?Glu?Gly?Thr?Leu?Asp?Glu?Leu?Val?Ala?Arg

210 215 220

Glu?Lys?Ser?Ile?Ile?Ser?Phe?Val?Leu?Arg?Gly?Gly?Gln?Val?Glu?Leu

225 230 235 240

Pro?Val?Leu?Ser?Gly?Ala?Glu?Ile?Ile?Arg?Asp?Asn?Asn?His?Val?Arg

245 250 255

Ile?Ala?Thr?Thr?Thr?Leu?Gln?Gln?His?Thr?Leu?Glu?Ile?Leu?Thr?Trp

260 265 270

Ala?Ala?Glu?Thr?Gly?Ile?Ala?Leu?Glu?Gly?Phe?Ala?Ala?Lys?Pro?Ala

275 280 285

Thr?Leu?Glu?Ser?Val?Phe?Met?Asp?Ile?Ala?Ser?Leu?Glu?Asn?Thr?Ser

290 295 300

Leu?Gln?Thr?Ala

305

<210>521

<211>1131

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1108)

<223>RXC01306

<400>521

tgttttagag?gtagagcgaa?acgtgcctgt?aaaactggcg?ctcgctgtgc?tcgaagacca?60

cccagacaat?caccccgctc?cgaaggagaa?tcgctaagcc?atg?act?gaa?tgg?tat 115

Met?Thr?Glu?Trp?Tyr

1 5

gtc?gtt?tta?ccc?gcc?act?att?cta?ctc?atc?gcg?ctg?tct?gcg?ttt?ttc 163

Val?Val?Leu?Pro?Ala?Thr?Ile?Leu?Leu?Ile?Ala?Leu?Ser?Ala?Phe?Phe

10 15 20

gtc?atc?att?gag?ttc?gct?ttg?ctt?gca?gct?agg?cgg?aac?cgg?tta?gag 211

Val?Ile?Ile?Glu?Phe?Ala?Leu?Leu?Ala?Ala?Arg?Arg?Asn?Arg?Leu?Glu

25 30 35

gag?act?gtg?gaa?acc?tcg?cgg?tct?tcc?cgc?gct?gcg?ttg?cga?agc?ctc 259

Glu?Thr?Val?Glu?Thr?Ser?Arg?Ser?Ser?Arg?Ala?Ala?Leu?Arg?Ser?Leu

40 45 50

aat?gaa?ctt?act?ctc?atg?ctc?gcg?ggc?gcg?cag?ttg?gga?atc?acc?atg 307

Asn?Glu?Leu?Thr?Leu?Met?Leu?Ala?Gly?Ala?Gln?Leu?Gly?Ile?Thr?Met

55 60 65

gtg?act?ttc?gcg?ttg?ggt?gct?atc?acg?aag?ccg?tgg?gtt?cat?tat?gct 355

Val?Thr?Phe?Ala?Leu?Gly?Ala?Ile?Thr?Lys?Pro?Trp?Val?His?Tyr?Ala

70 75 80 85

ttg?atg?ccg?ctc?ttc?gaa?tgg?gcg?cgt?ata?ccg?ctg?gtt?atg?gca?gat 403

Leu?Met?Pro?Leu?Phe?Glu?Trp?Ala?Arg?Ile?Pro?Leu?Val?Met?Ala?Asp

90 95 100

gtc?att?gcg?ttt?att?ttg?tcg?ctg?ttt?atc?gta?acg?ttt?ctg?cac?ttg 451

Val?Ile?Ala?Phe?Ile?Leu?Ser?Leu?Phe?Ile?Val?Thr?Phe?Leu?His?Leu

105 110 115

gtc?atc?ggc?gaa?atg?gct?ccg?aaa?tcc?tgg?gca?atc?gcg?cat?ccg?gag 499

Val?Ile?Gly?Glu?Met?Ala?Pro?Lys?Ser?Trp?Ala?Ile?Ala?His?Pro?Glu

120 125 130

acg?gca?ctt?cga?act?atc?gcg?att?ccc?gca?cgg?ggc?ttc?att?aac?ctg 547

Thr?Ala?Leu?Arg?Thr?Ile?Ala?Ile?Pro?Ala?Arg?Gly?Phe?Ile?Asn?Leu

135 140 145

ttt?cgt?cca?ttg?ctg?cag?tgg?atc?aac?aaa?atg?gcg?aac?gat?ttg?gtc 595

Phe?Arg?Pro?Leu?Leu?Gln?Trp?Ile?Asn?Lys?Met?Ala?Asn?Asp?Leu?Val

150 155 160 165

cgc?aaa?gtt?ggt?gaa?act?ccc?gtt?gat?cga?gct?gca?gct?ggt?ggc?tat 643

Arg?Lys?Val?Gly?Glu?Thr?Pro?Val?Asp?Arg?Ala?Ala?Ala?Gly?Gly?Tyr

170 175 180

gac?acc?gat?acc?ctc?cat?gcc?ctc?att?gag?cat?tcc?cga?gaa?act?ggc 691

Asp?Thr?Asp?Thr?Leu?His?Ala?Leu?Ile?Glu?His?Ser?Arg?Glu?Thr?Gly

185 190 195

gct?ctg?gat?cag?caa?tcc?gcc?gcc?caa?atc?agc?gga?att?atc?aag?ctg 739

Ala?Leu?Asp?Gln?Gln?Ser?Ala?Ala?Gln?Ile?Ser?Gly?Ile?Ile?Lys?Leu

200 205 210

gat?aaa?atc?acg?gtc?ggt?caa?acc?ctg?acc?gca?tct?cca?ttt?acg?cac 787

Asp?Lys?Ile?Thr?Val?Gly?Gln?Thr?Leu?Thr?Ala?Ser?Pro?Phe?Thr?His

215 220 225

agc?gcc?agc?gcc?acg?gtt?gct?gag?gtg?caa?gcc?gca?gct?cag?cgc?agt 835

Ser?Ala?Ser?Ala?Thr?Val?Ala?Glu?Val?Gln?Ala?Ala?Ala?Gln?Arg?Ser

230 235 240 245

ggc?agc?ttg?cgt?gtg?ctt?atc?gac?gcc?ccc?tcc?cac?ctt?ttc?cca?cac 883

Gly?Ser?Leu?Arg?Val?Leu?Ile?Asp?Ala?Pro?Ser?His?Leu?Phe?Pro?His

250 255 260

gtc?att?cat?gtg?cga?gac?acc?ctt?ggt?gcc?tcg?cca?gac?gag?aag?gct 931

Val?Ile?His?Val?Arg?Asp?Thr?Leu?Gly?Ala?Ser?Pro?Asp?Glu?Lys?Ala

265 270 275

tcg?aag?tgg?tct?cgc?cca?atc?ctc?acc?gtt?gct?gag?acc?gac?acg?tta 979

Ser?Lys?Trp?Ser?Arg?Pro?Ile?Leu?Thr?Val?Ala?Glu?Thr?Asp?Thr?Leu

280 285 290

cac?caa?gcg?ctg?gaa?tac?atg?cgg?gag?cat?aac?gag?cag?atc?agt?gcg 1027

His?Gln?Ala?Leu?Glu?Tyr?Met?Arg?Glu?His?Asn?Glu?Gln?Ile?Ser?Ala

295 300 305

gtg?ctt?tcc?gct?gat?ggg?aaa?acg?gtg?ctt?ggt?gta?ata?act?tgg?gat 1075

Val?Leu?Ser?Ala?Asp?Gly?Lys?Thr?Val?Leu?Gly?Val?Ile?Thr?Trp?Asp

310 315 320 325

cac?atc?ttg?aaa?tac?ctg?tgg?cct?gca?tcg?gtg?tagctaattt?gaggtgcgct?1128

His?Ile?Leu?Lys?Tyr?Leu?Trp?Pro?Ala?Ser?Val

330 335

gaa 1131

<210>522

<211>336

<212>PRT

＜213〉Corynebacterium glutamicum

<400>522

Met?Thr?Glu?Trp?Tyr?Val?Val?Leu?Pro?Ala?Thr?Ile?Leu?Leu?Ile?Ala

1 5 10 15

Leu?Ser?Ala?Phe?Phe?Val?Ile?Ile?Glu?Phe?Ala?Leu?Leu?Ala?Ala?Arg

20 25 30

Arg?Asn?Arg?Leu?Glu?Glu?Thr?Val?Glu?Thr?Ser?Arg?Ser?Ser?Arg?Ala

35 40 45

Ala?Leu?Arg?Ser?Leu?Asn?Glu?Leu?Thr?Leu?Met?Leu?Ala?Gly?Ala?Gln

50 55 60

Leu?Gly?Ile?Thr?Met?Val?Thr?Phe?Ala?Leu?Gly?Ala?Ile?Thr?Lys?Pro

65 70 75 80

Trp?Val?His?Tyr?Ala?Leu?Met?Pro?Leu?Phe?Glu?Trp?Ala?Arg?Ile?Pro

85 90 95

Leu?Val?Met?Ala?Asp?Val?Ile?Ala?Phe?Ile?Leu?Ser?Leu?Phe?Ile?Val

100 105 110

Thr?Phe?Leu?His?Leu?Val?Ile?Gly?Glu?Met?Ala?Pro?Lys?Ser?Trp?Ala

115 120 125

Ile?Ala?His?Pro?Glu?Thr?Ala?Leu?Arg?Thr?Ile?Ala?Ile?Pro?Ala?Arg

130 135 140

Gly?Phe?Ile?Asn?Leu?Phe?Arg?Pro?Leu?Leu?Gln?Trp?Ile?Asn?Lys?Met

145 150 155 160

Ala?Asn?Asp?Leu?Val?Arg?Lys?Val?Gly?Glu?Thr?Pro?Val?Asp?Arg?Ala

165 170 175

Ala?Ala?Gly?Gly?Tyr?Asp?Thr?Asp?Thr?Leu?His?Ala?Leu?Ile?Glu?His

180 185 190

Ser?Arg?Glu?Thr?Gly?Ala?Leu?Asp?Gln?Gln?Ser?Ala?Ala?Gln?Ile?Ser

195 200 205

Gly?Ile?Ile?Lys?Leu?Asp?Lys?Ile?Thr?Val?Gly?Gln?Thr?Leu?Thr?Ala

210 215 220

Ser?Pro?Phe?Thr?His?Ser?Ala?Ser?Ala?Thr?Val?Ala?Glu?Val?Gln?Ala

225 230 235 240

Ala?Ala?Gln?Arg?Ser?Gly?Ser?Leu?Arg?Val?Leu?Ile?Asp?Ala?Pro?Ser

245 250 255

His?Leu?Phe?Pro?His?Val?Ile?His?Val?Arg?Asp?Thr?Leu?Gly?Ala?Ser

260 265 270

Pro?Asp?Glu?Lys?Ala?Ser?Lys?Trp?Ser?Arg?Pro?Ile?Leu?Thr?Val?Ala

275 280 285

Glu?Thr?Asp?Thr?Leu?His?Gln?Ala?Leu?Glu?Tyr?Met?Arg?Glu?His?Asn

290 295 300

Glu?Gln?Ile?Ser?Ala?Val?Leu?Ser?Ala?Asp?Gly?Lys?Thr?Val?Leu?Gly

305 310 315 320

Val?Ile?Thr?Trp?Asp?His?Ile?Leu?Lys?Tyr?Leu?Trp?Pro?Ala?Ser?Val

325 330 335

<210>523

<211>513

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(490)

<223>RXC01366

<400>523

atgcatgaaa?acaaattcta?tgtgtgttga?gctgccaaaa?ggggttggcg?cgccgatgat?60

gactgtccaa?acctaaacca?aaggtctaaa?ctttggcttc?gtg?agt?cag?ttt?cgt 115

Val?Ser?Gln?Phe?Arg

1 5

cgt?tgt?tcc?cgc?cct?ggt?tgt?ggc?aag?cct?gcc?gtc?gca?acc?ctc?acc 163

Arg?Cys?Ser?Arg?Pro?Gly?Cys?Gly?Lys?Pro?Ala?Val?Ala?Thr?Leu?Thr

10 15 20

tac?gca?tat?tcg?gat?tcc?act?gcg?gtg?gtt?ggt?cct?ttg?gcg?cct?gca 211

Tyr?Ala?Tyr?Ser?Asp?Ser?Thr?Ala?Val?Val?Gly?Pro?Leu?Ala?Pro?Ala

25 30 35

gca?gag?ccc?cat?agt?tgg?gat?ctg?tgt?gag?cat?cat?gcc?gag?cgt?att 259

Ala?Glu?Pro?His?Ser?Trp?Asp?Leu?Cys?Glu?His?His?Ala?Glu?Arg?Ile

40 45 50

act?gcg?ccc?ctt?ggt?tgg?gag?atg?ctg?cgg?gtg?aac?gac?atc?aaa?gtc 307

Thr?Ala?Pro?Leu?Gly?Trp?Glu?Met?Leu?Arg?Val?Asn?Asp?Ile?Lys?Val

55 60 65

gat?gac?gat?gag?gat?ctg?acg?gct?ctt?gct?cag?gct?gtt?cgt?gag?gct 355

Asp?Asp?Asp?Glu?Asp?Leu?Thr?Ala?Leu?Ala?Gln?Ala?Val?Arg?Glu?Ala

70 75 80 85

gga?cgc?act?gtg?agt?ggt?ctg?gtt?cct?gaa?gac?gaa?gtg?ggc?ggc?aac 403

Gly?Arg?Thr?Val?Ser?Gly?Leu?Val?Pro?Glu?Asp?Glu?Val?Gly?Gly?Asn

90 95 100

cat?ccg?gtg?aac?cgg?agt?gcg?cgg?atc?gcg?gaa?cag?aag?gtt?cac?cgc 451

His?Pro?Val?Asn?Arg?Ser?Ala?Arg?Ile?Ala?Glu?Gln?Lys?Val?His?Arg

105 110 115

agg?ggt?cat?ctc?tat?gtt?gtg?cct?gat?cag?gac?gaa?tca?taaggtttgc 500

Arg?Gly?His?Leu?Tyr?Val?Val?Pro?Asp?Gln?Asp?Glu?Ser

120 125 130

tattcggatt?gga 513

<210>524

<211>130

<212>PRT

＜213〉Corynebacterium glutamicum

<400>524

Val?Ser?Gln?Phe?Arg?Arg?Cys?Ser?Arg?Pro?Gly?Cys?Gly?Lys?Pro?Ala

1 5 10 15

Val?Ala?Thr?Leu?Thr?Tyr?Ala?Tyr?Ser?Asp?Ser?Thr?Ala?Val?Val?Gly

20 25 30

Pro?Leu?Ala?Pro?Ala?Ala?Glu?Pro?His?Ser?Trp?Asp?Leu?Cys?Glu?His

35 40 45

His?Ala?Glu?Arg?Ile?Thr?Ala?Pro?Leu?Gly?Trp?Glu?Met?Leu?Arg?Val

50 55 60

Asn?Asp?Ile?Lys?Val?Asp?Asp?Asp?Glu?Asp?Leu?Thr?Ala?Leu?Ala?Gln

65 70 75 80

Ala?Val?Arg?Glu?Ala?Gly?Arg?Thr?Val?Ser?Gly?Leu?Val?Pro?Glu?Asp

85 90 95

Glu?Val?Gly?Gly?Asn?His?Pro?Val?Asn?Arg?Ser?Ala?Arg?Ile?Ala?Glu

100 105 110

Gln?Lys?Val?His?Arg?Arg?Gly?His?Leu?Tyr?Val?Val?Pro?Asp?Gln?Asp

115 120 125

Glu?Ser

130

<210>525

<211>614

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(591)

<223>RXC01372

<400>525

cag?gac?acc?ttc?gtc?ctt?ccc?acc?ttg?ccc?acg?gcc?gca?ggc?ttg?tcg 48

Gln?Asp?Thr?Phe?Val?Leu?Pro?Thr?Leu?Pro?Thr?Ala?Ala?Gly?Leu?Ser

1 5 10 15

cct?gcc?cgc?atc?gtg?gcg?tcg?ata?agc?act?ctt?tta?gat?ctt?tta?gaa 96

Pro?Ala?Arg?Ile?Val?Ala?Ser?Ile?Ser?Thr?Leu?Leu?Asp?Leu?Leu?Glu

20 25 30

gca?gac?ccc?agc?att?att?tcc?gac?cgc?ttg?gaa?cac?ctc?gcc?gac?tgc 144

Ala?Asp?Pro?Ser?Ile?Ile?Ser?Asp?Arg?Leu?Glu?His?Leu?Ala?Asp?Cys

35 40 45

att?gat?gag?gaa?gtg?gaa?tcg?cta?tcg?ccg?gaa?cgt?gac?gaa?cta?gtc 192

Ile?Asp?Glu?Glu?Val?Glu?Ser?Leu?Ser?Pro?Glu?Arg?Asp?Glu?Leu?Val

50 55 60

aat?ccc?ggc?cga?aaa?ctg?cgc?gca?tac?gta?gat?cac?gca?cgg?atc?gtg 240

Asn?Pro?Gly?Arg?Lys?Leu?Arg?Ala?Tyr?Val?Asp?His?Ala?Arg?Ile?Val

65 70 75 80

cat?acc?ggc?cga?act?gat?gtg?gga?ctc?gcg?att?gcc?aac?gtt?atc?gcc 288

His?Thr?Gly?Arg?Thr?Asp?Val?Gly?Leu?Ala?Ile?Ala?Asn?Val?Ile?Ala

85 90 95

cca?atc?tgg?acc?cga?cga?ggc?ctg?gta?tca?gcc?gtg?ctg?gat?ttt?ccc 336

Pro?Ile?Trp?Thr?Arg?Arg?Gly?Leu?Val?Ser?Ala?Val?Leu?Asp?Phe?Pro

100 105 110

gag?ctc?atg?gaa?tca?ttg?ccg?gaa?ctc?cgc?gga?ccc?gag?cca?att?acc 384

Glu?Leu?Met?Glu?Ser?Leu?Pro?Glu?Leu?Arg?Gly?Pro?Glu?Pro?Ile?Thr

115 120 125

gac?gat?ata?ttc?cat?gac?cca?ttc?ata?gat?gac?gaa?ccc?ggg?gtg?gta 432

Asp?Asp?Ile?Phe?His?Asp?Pro?Phe?Ile?Asp?Asp?Glu?Pro?Gly?Val?Val

130 135 140

ccg?ttt?agg?gct?gtt?gtc?tgg?gcc?gaa?gag?gaa?ccc?gga?atc?ccc?gat 480

Pro?Phe?Arg?Ala?Val?Val?Trp?Ala?Glu?Glu?Glu?Pro?Gly?Ile?Pro?Asp

145 150 155 160

gcc?atg?gcg?caa?agc?tgc?gac?gga?cct?agc?aaa?ggg?gcg?ctg?aca?caa 528

Ala?Met?Ala?Gln?Ser?Cys?Asp?Gly?Pro?Ser?Lys?Gly?Ala?Leu?Thr?Gln

165 170 175

gca?ctg?cgt?ttg?ctg?gtg?cgc?gga?cag?tca?gcc?acg?acc?tat?tcc?att 576

Ala?Leu?Arg?Leu?Leu?Val?Arg?Gly?Gln?Ser?Ala?Thr?Thr?Tyr?Ser?Ile

180 185 190

gaa?gaa?aag?gac?ttg?taaatggagc?tattggaagg?ctc 614

Glu?Glu?Lys?Asp?Leu

195

<210>526

<211>197

<212>PRT

＜213〉Corynebacterium glutamicum

<400>526

Gln?Asp?Thr?Phe?Val?Leu?Pro?Thr?Leu?Pro?Thr?Ala?Ala?Gly?Leu?Ser

1 5 10 15

Pro?Ala?Arg?Ile?Val?Ala?Ser?Ile?Ser?Thr?Leu?Leu?Asp?Leu?Leu?Glu

20 25 30

Ala?Asp?Pro?Ser?Ile?Ile?Ser?Asp?Arg?Leu?Glu?His?Leu?Ala?Asp?Cys

35 40 45

Ile?Asp?Glu?Glu?Val?Glu?Ser?Leu?Ser?Pro?Glu?Arg?Asp?Glu?Leu?Val

50 55 60

Asn?Pro?Gly?Arg?Lys?Leu?Arg?Ala?Tyr?Val?Asp?His?Ala?Arg?Ile?Val

65 70 75 80

His?Thr?Gly?Arg?Thr?Asp?Val?Gly?Leu?Ala?Ile?Ala?Asn?Val?Ile?Ala

85 90 95

Pro?Ile?Trp?Thr?Arg?Arg?Gly?Leu?Val?Ser?Ala?Val?Leu?Asp?Phe?Pro

100 105 110

Glu?Leu?Met?Glu?Ser?Leu?Pro?Glu?Leu?Arg?Gly?Pro?Glu?Pro?Ile?Thr

115 120 125

Asp?Asp?Ile?Phe?His?Asp?Pro?Phe?Ile?Asp?Asp?Glu?Pro?Gly?Val?Val

130 135 140

Pro?Phe?Arg?Ala?Val?Val?Trp?Ala?Glu?Glu?Glu?Pro?Gly?Ile?Pro?Asp

145 150 155 160

Ala?Met?Ala?Gln?Ser?Cys?Asp?Gly?Pro?Ser?Lys?Gly?Ala?Leu?Thr?Gln

165 170 175

Ala?Leu?Arg?Leu?Leu?Val?Arg?Gly?Gln?Ser?Ala?Thr?Thr?Tyr?Ser?Ile

180 185 190

Glu?Glu?Lys?Asp?Leu

195

<210>527

<211>669

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(646)

<223>RXC01659

<400>527

ttgatgcgcg?ccgcggtgag?cagcctgccg?atccagagcg?tgaagaatct?gatgatttag?60

tcgagattga?taccgtctct?ggattccgcc?tgctcagtac?gtg?gcg?ggg?gtt?gcg 115

Val?Ala?Gly?Val?Ala

1 5

cag?cgt?ttt?gtc?gac?gag?cgc?att?cac?gtc?ggt?ttg?gat?tcc?atg?cca 163

Gln?Arg?Phe?Val?Asp?Glu?Arg?Ile?His?Val?Gly?Leu?Asp?Ser?Met?Pro

10 15 20

gaa?gct?gtg?act?gct?gtg?tgg?atg?gaa?tct?gat?tgg?gtg?ttg?gcg?gaa 211

Glu?Ala?Val?Thr?Ala?Val?Trp?Met?Glu?Ser?Asp?Trp?Val?Leu?Ala?Glu

25 30 35

acc?atc?aag?ggt?tcc?acg?cct?tcc?gat?tgg?gaa?gag?att?ttg?cgg?ccg 259

Thr?Ile?Lys?Gly?Ser?Thr?Pro?Ser?Asp?Trp?Glu?Glu?Ile?Leu?Arg?Pro

40 45 50

ttg?gcg?ctg?ctc?acg?gac?gcg?tct?ttc?acg?ttg?cca?cct?cgt?tcc?acg 307

Leu?Ala?Leu?Leu?Thr?Asp?Ala?Ser?Phe?Thr?Leu?Pro?Pro?Arg?Ser?Thr

55 60 65

cgt?gcg?caa?acc?ttg?gat?ttg?aag?cat?ttg?gaa?cca?agc?cgt?ctg?aag 355

Arg?Ala?Gln?Thr?Leu?Asp?Leu?Lys?His?Leu?Glu?Pro?Ser?Arg?Leu?Lys

70 75 80 85

ccg?gag?cag?cca?gaa?aag?cca?gcg?ttt?act?ccc?aat?gct?tcg?gaa?gaa 403

Pro?Glu?Gln?Pro?Glu?Lys?Pro?Ala?Phe?Thr?Pro?Asn?Ala?Ser?Glu?Glu

90 95 100

gat?ttg?tct?cag?ccg?ttg?gtg?atc?cgc?ccc?gag?gag?ccg?ttg?cag?atg 451

Asp?Leu?Ser?Gln?Pro?Leu?Val?Ile?Arg?Pro?Glu?Glu?Pro?Leu?Gln?Met

105 110 115

ccg?gtt?cgc?ggt?gtg?cag?gaa?agc?cgc?gga?gtg?gtc?gag?cca?cgg?tca 499

Pro?Val?Arg?Gly?Val?Gln?Glu?Ser?Arg?Gly?Val?Val?Glu?Pro?Arg?Ser

120 125 130

ttg?ggt?gcg?gat?gat?gtg?gag?tcg?att?gcg?gag?ggc?gat?cca?gag?cgt 547

Leu?Gly?Ala?Asp?Asp?Val?Glu?Ser?Ile?Ala?Glu?Gly?Asp?Pro?Glu?Arg

135 140 145

ccg?agc?gat?ctt?tat?ggc?acg?cgt?gtg?ctg?cgt?gat?ctc?aat?ggt?cag 595

Pro?Ser?Asp?Leu?Tyr?Gly?Thr?Arg?Val?Leu?Arg?Asp?Leu?Asn?Gly?Gln

150 155 160 165

tcc?agt?att?ttc?caa?gat?tcc?acc?gac?gcg?gat?gag?cca?cca?aaa?aag 643

Ser?Ser?Ile?Phe?Gln?Asp?Ser?Thr?Asp?Ala?Asp?Glu?Pro?Pro?Lys?Lys

170 175 180

tgg?tagaaaactg?gtgtttttcg?gcc 669

Trp

<210>528

<21l>182

<212>PRT

＜213〉Corynebacterium glutamicum

<400>528

Val?Ala?Gly?Val?Ala?Gln?Arg?Phe?Val?Asp?Glu?Arg?Ile?His?Val?Gly

1 5 10 15

Leu?Asp?Ser?Met?Pro?Glu?Ala?Val?Thr?Ala?Val?Trp?Met?Glu?Ser?Asp

20 25 30

Trp?Val?Leu?Ala?Glu?Thr?Ile?Lys?Gly?Ser?Thr?Pro?Ser?Asp?Trp?Glu

35 40 45

Glu?Ile?Leu?Arg?Pro?Leu?Ala?Leu?Leu?Thr?Asp?Ala?Ser?Phe?Thr?Leu

50 55 60

Pro?Pro?Arg?Ser?Thr?Arg?Ala?Gln?Thr?Leu?Asp?Leu?Lys?His?Leu?Glu

65 70 75 80

Pro?Ser?Arg?Leu?Lys?Pro?Glu?Gln?Pro?Glu?Lys?Pro?Ala?Phe?Thr?Pro

85 90 95

Asn?Ala?Ser?Glu?Glu?Asp?Leu?Ser?Gln?Pro?Leu?Val?Ile?Arg?Pro?Glu

100 105 110

Glu?Pro?Leu?Gln?Met?Pro?Val?Arg?Gly?Val?Gln?Glu?Ser?Arg?Gly?Val

115 120 125

Val?Glu?Pro?Arg?Ser?Leu?Gly?Ala?Asp?Asp?Val?Glu?Ser?Ile?Ala?Glu

130 135 140

Gly?Asp?Pro?Glu?Arg?Pro?Ser?Asp?Leu?Tyr?Gly?Thr?Arg?Val?Leu?Arg

145 150 155 160

Asp?Leu?Asn?Gly?Gln?Ser?Ser?Ile?Phe?Gln?Asp?Ser?Thr?Asp?Ala?Asp

165 170 175

Glu?Pro?Pro?Lys?Lys?Trp

180

<210>529

<211>981

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(958)

<223>RXC01663

<400>529

tattttgctg?gttggtcaca?gtggagcgct?aaccccgaga?atcctatcga?ggcctaaaat?60

cgtggcttga?gtacgcactg?ccagtaaggt?gtgtgatgtg?atg?gaa?ata?agt?gtc 115

Met?Glu?Ile?Ser?Val

1 5

ttg?atc?atc?gcc?gca?ctg?atc?ttg?gtg?gca?ggc?atc?gta?ctg?tgg?cgc 163

Leu?Ile?Ile?Ala?Ala?Leu?Ile?Leu?Val?Ala?Gly?Ile?Val?Leu?Trp?Arg

10 15 20

gcg?gac?tcg?tct?aaa?cag?gca?gct?aaa?aag?gct?gaa?tca?cct?gtg?ggc 211

Ala?Asp?Ser?Ser?Lys?Gln?Ala?Ala?Lys?Lys?Ala?Glu?Ser?Pro?Val?Gly

25 30 35

tca?gtc?gca?cct?gcg?ccc?gtg?ctg?gtt?gaa?gaa?gag?ccg?gac?cct?gag 259

Ser?Val?Ala?Pro?Ala?Pro?Val?Leu?Val?Glu?Glu?Glu?Pro?Asp?Pro?Glu

40 45 50

ttt?gag?cca?gaa?ctg?gac?cct?gaa?cca?gaa?gcg?caa?cca?gaa?cca?gag 307

Phe?Glu?Pro?Glu?Leu?Asp?Pro?Glu?Pro?Glu?Ala?Gln?Pro?Glu?Pro?Glu

55 60 65

ctg?gaa?gtt?gcg?cct?aga?ttt?gcg?cca?gaa?cca?gtt?caa?gat?ctt?gag 355

Leu?Glu?Val?Ala?Pro?Arg?Phe?Ala?Pro?Glu?Pro?Val?Gln?Asp?Leu?Glu

70 75 80 85

ccg?gat?cag?gct?gag?gac?att?tat?ttt?gat?gat?tcc?cct?gaa?ctc?gat 403

Pro?Asp?Gln?Ala?Glu?Asp?Ile?Tyr?Phe?Asp?Asp?Ser?Pro?Glu?Leu?Asp

90 95 100

gct?gat?gtt?gaa?aat?gcc?ttg?gct?gag?ctt?act?gag?gta?gaa?gac?tac 451

Ala?Asp?Val?Glu?Asn?Ala?Leu?Ala?Glu?Leu?Thr?Glu?Val?Glu?Asp?Tyr

105 110 115

ccg?gaa?gag?cca?gtg?cag?tct?gag?caa?cct?caa?gcc?cct?gcc?acg?gcg 499

Pro?Glu?Glu?Pro?Val?Gln?Ser?Glu?Gln?Pro?Gln?Ala?Pro?Ala?Thr?Ala

120 125 130

gag?gta?gct?gcg?gac?gag?gag?caa?cgg?ggc?gtc?gat?aag?cat?tcg?ttt 547

Glu?Val?Ala?Ala?Asp?Glu?Glu?Gln?Arg?Gly?Val?Asp?Lys?His?Ser?Phe

135 140 145

ttg?agc?tct?ttg?cct?ggt?tcg?cag?cgc?cgg?gag?cgc?cga?aac?tgg?gcg 595

Leu?Ser?Ser?Leu?Pro?Gly?Ser?Gln?Arg?Arg?Glu?Arg?Arg?Asn?Trp?Ala

150 155 160 165

gcg?aag?cac?cac?ttc?gat?ttc?atc?aag?gaa?gat?gcc?ttt?ttg?acc?gat 643

Ala?Lys?His?His?Phe?Asp?Phe?Ile?Lys?Glu?Asp?Ala?Phe?Leu?Thr?Asp

170 175 180

gaa?tgg?tca?agg?ggt?gcg?gca?tcg?act?ggt?gcc?gtt?gca?cgt?gat?gtg 691

Glu?Trp?Ser?Arg?Gly?Ala?Ala?Ser?Thr?Gly?Ala?Val?Ala?Arg?Asp?Val

185 190 195

gtc?agt?ggc?atg?gct?gaa?gga?tat?gaa?acg?cat?ctg?gtg?gat?ttg?gcg 739

Val?Ser?Gly?Met?Ala?Glu?Gly?Tyr?Glu?Thr?His?Leu?Val?Asp?Leu?Ala

200 205 210

ggc?gtg?ccc?gtg?atg?gcg?atg?cgc?cgt?gga?att?acc?tct?gac?gtg?gtc 787

Gly?Val?Pro?Val?Met?Ala?Met?Arg?Arg?Gly?Ile?Thr?Ser?Asp?Val?Val

215 220 225

att?gat?gcg?cgc?cgc?ggt?gag?cag?cct?gcc?gat?cca?gag?cgt?gaa?gaa 835

Ile?Asp?Ala?Arg?Arg?Gly?Glu?Gln?Pro?Ala?Asp?Pro?Glu?Arg?Glu?Glu

230 235 240 245

tct?gat?gat?tta?gtc?gag?att?gat?acc?gtc?tct?gga?ttc?cgc?ctg?ctc 883

Ser?Asp?Asp?Leu?Val?Glu?Ile?Asp?Thr?Val?Ser?Gly?Phe?Arg?Leu?Leu

250 255 260

agt?acg?tgg?cgg?ggg?ttg?cgc?agc?gtt?ttg?tcg?acg?agc?gca?ttc?acg 931

Ser?Thr?Trp?Arg?Gly?Leu?Arg?Ser?Val?Leu?Ser?Thr?Ser?Ala?Phe?Thr

265 270 275

tcg?gtt?tgg?att?cca?tgc?cag?aag?ctg?tgactgctgt?gtggatggaa 978

Ser?Val?Trp?Ile?Pro?Cys?Gln?Lys?Leu

280 285

tct 981

<210>530

<211>286

<212>PRT

＜213〉Corynebacterium glutamicum

<400>530

Met?Glu?Ile?Ser?Val?Leu?Ile?Ile?Ala?Ala?Leu?Ile?Leu?Val?Ala?Gly

1 5 10 15

Ile?Val?Leu?Trp?Arg?Ala?Asp?Ser?Ser?Lys?Gln?Ala?Ala?Lys?Lys?Ala

20 25 30

Glu?Ser?Pro?Val?Gly?Ser?Val?Ala?Pro?Ala?Pro?Val?Leu?Val?Glu?Glu

35 40 45

Glu?Pro?Asp?Pro?Glu?Phe?Glu?Pro?Glu?Leu?Asp?Pro?Glu?Pro?Glu?Ala

50 55 60

Gln?Pro?Glu?Pro?Glu?Leu?Glu?Val?Ala?Pro?Arg?Phe?Ala?Pro?Glu?Pro

65 70 75 80

Val?Gln?Asp?Leu?Glu?Pro?Asp?Gln?Ala?Glu?Asp?Ile?Tyr?Phe?Asp?Asp

85 90 95

Ser?Pro?Glu?Leu?Asp?Ala?Asp?Val?Glu?Asn?Ala?Leu?Ala?Glu?Leu?Thr

100 105 110

Glu?Val?Glu?Asp?Tyr?Pro?Glu?Glu?Pro?Val?Gln?Ser?Glu?Gln?Pro?Gln

115 120 125

Ala?Pro?Ala?Thr?Ala?Glu?Val?Ala?Ala?Asp?Glu?Glu?Gln?Arg?Gly?Val

130 135 140

Asp?Lys?His?Ser?Phe?Leu?Ser?Ser?Leu?Pro?Gly?Ser?Gln?Arg?Arg?Glu

145 150 155 160

Arg?Arg?Asn?Trp?Ala?Ala?Lys?His?His?Phe?Asp?Phe?Ile?Lys?Glu?Asp

165 170 175

Ala?Phe?Leu?Thr?Asp?Glu?Trp?Ser?Arg?Gly?Ala?Ala?Ser?Thr?Gly?Ala

180 185 190

Val?Ala?Arg?Asp?Val?Val?Ser?Gly?Met?Ala?Glu?Gly?Tyr?Glu?Thr?His

195 200 205

Leu?Val?Asp?Leu?Ala?Gly?Val?Pro?Val?Met?Ala?Met?Arg?Arg?Gly?Ile

210 215 220

Thr?Ser?Asp?Val?Val?Ile?Asp?Ala?Arg?Arg?Gly?Glu?Gln?Pro?Ala?Asp

225 230 235 240

Pro?Glu?Arg?Glu?Glu?Ser?Asp?Asp?Leu?Val?Glu?Ile?Asp?Thr?Val?Ser

245 250 255

Gly?Phe?Arg?Leu?Leu?Ser?Thr?Trp?Arg?Gly?Leu?Arg?Ser?Val?Leu?Ser

260 265 270

Thr?Ser?Ala?Phe?Thr?Ser?Val?Trp?Ile?Pro?Cys?Gln?Lys?Leu

275 280 285

<210>531

<211>1545

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1522)

<223>RXC01693

<400>531

aggagactgg?ctggattatt?ggctggtttt?cttgggaaat?cgtcatgggc?attaatccta?60

gtcccaacaa?ttgccagaac?ccgaacacta?ggcttgaacc?atg?aat?act?gca?cct 115

Met?Asn?Thr?Ala?Pro

1 5

ttc?aaa?ctc?gaa?gct?gac?ttc?gca?tca?gcc?ctg?ccc?acc?atg?gca?gcc 163

Phe?Lys?Leu?Glu?Ala?Asp?Phe?Ala?Ser?Ala?Leu?Pro?Thr?Met?Ala?Ala

10 15 20

ccc?tgg?caa?ggt?gag?gaa?gcc?ccc?aac?cct?gag?ctc?gtg?att?tta?aat 211

Pro?Trp?Gln?Gly?Glu?Glu?Ala?Pro?Asn?Pro?Glu?Leu?Val?Ile?Leu?Asn

25 30 35

gac?gac?ctc?gcc?tac?agc?ctc?ggg?ctt?gat?ccg?aca?tgg?ctt?cgc?aca 259

Asp?Asp?Leu?Ala?Tyr?Ser?Leu?Gly?Leu?Asp?Pro?Thr?Trp?Leu?Arg?Thr

40 45 50

cct?gag?ggc?gtt?caa?ttt?ctt?ctc?gga?ctc?aac?ccc?gag?ccc?tta?aca 307

Pro?Glu?Gly?Val?Gln?Phe?Leu?Leu?Gly?Leu?Asn?Pro?Glu?Pro?Leu?Thr

55 60 65

aaa?gca?gtt?gcg?cag?gcc?tat?tcc?ggc?cac?caa?ttc?gga?cag?ttt?gtg 355

Lys?Ala?Val?Ala?Gln?Ala?Tyr?Ser?Gly?His?Gln?Phe?Gly?Gln?Phe?Val

70 75 80 85

gca?agc?ctt?ggt?gat?ggc?cga?gcg?ctt?ctt?ctc?ggc?gaa?gcc?cgc?tca 403

Ala?Ser?Leu?Gly?Asp?Gly?Arg?Ala?Leu?Leu?Leu?Gly?Glu?Ala?Arg?Ser

90 95 100

gct?gac?ggc?gta?ctg?cat?gat?atc?cac?ctc?aaa?gga?tct?gga?cga?acc 451

Ala?Asp?Gly?Val?Leu?His?Asp?Ile?His?Leu?Lys?Gly?Ser?Gly?Arg?Thr

105 110 115

caa?ttc?tcc?cga?gga?gcc?gat?gga?cgc?gcc?gtc?ctt?ggc?ccc?gtc?tta 499

Gln?Phe?Ser?Arg?Gly?Ala?Asp?Gly?Arg?Ala?Val?Leu?Gly?Pro?Val?Leu

120 125 130

cgc?gaa?tac?atc?atc?tcc?gaa?gcg?atg?cat?gca?ctt?ggt?gtt?ccc?acc 547

Arg?Glu?Tyr?Ile?Ile?Ser?Glu?Ala?Met?His?Ala?Leu?Gly?Val?Pro?Thr

135 140 145

acc?agg?tca?ctt?gca?gta?att?agc?acc?ggt?agg?aaa?atc?caa?cga?gga 595

Thr?Arg?Ser?Leu?Ala?Val?Ile?Ser?Thr?Gly?Arg?Lys?Ile?Gln?Arg?Gly

150 155 160 165

agc?gta?gcc?cca?ggc?gca?gtc?ctt?gtt?cga?gta?gca?acc?agc?ctc?att 643

Ser?Val?Ala?Pro?Gly?Ala?Val?Leu?Val?Arg?Val?Ala?Thr?Ser?Leu?Ile

170 175 180

cga?gtc?gga?tcc?ttc?caa?tac?tcc?aac?atc?tct?ggt?ggc?atc?gaa?cta 691

Arg?Val?Gly?Ser?Phe?Gln?Tyr?Ser?Asn?Ile?Ser?Gly?Gly?Ile?Glu?Leu

185 190 195

tct?caa?cac?ctg?gcg?aac?tat?acg?atc?acc?agg?cat?ttc?cct?tcg?ttg 739

Ser?Gln?His?Leu?Ala?Asn?Tyr?Thr?Ile?Thr?Arg?His?Phe?Pro?Ser?Leu

200 205 210

gta?gct?gaa?cta?tcc?gca?cca?acc?ccc?gca?act?tat?gta?tca?ctg?ttt 787

Val?Ala?Glu?Leu?Ser?Ala?Pro?Thr?Pro?Ala?Thr?Tyr?Val?Ser?Leu?Phe

215 220 225

aaa?gcg?att?ctt?cag?cgc?caa?gca?gac?acc?gtt?gga?aaa?tgg?acc?agg 835

Lys?Ala?Ile?Leu?Gln?Arg?Gln?Ala?Asp?Thr?Val?Gly?Lys?Trp?Thr?Arg

230 235 240 245

ctg?ggt?ttc?gtt?cac?gga?gcc?ctc?aac?aca?gac?aac?acg?ttg?ata?tcc 883

Leu?Gly?Phe?Val?His?Gly?Ala?Leu?Asn?Thr?Asp?Asn?Thr?Leu?Ile?Ser

250 255 260

gga?gaa?act?gtt?gac?tac?ggc?cca?tgc?gct?ttc?atg?gag?cgc?tac?cgt 931

Gly?Glu?Thr?Val?Asp?Tyr?Gly?Pro?Cys?Ala?Phe?Met?Glu?Arg?Tyr?Arg

265 270 275

ggc?gac?gcg?aaa?ttt?agc?tcc?atc?gac?act?tat?ggt?cgc?tac?aaa?ttt 979

Gly?Asp?Ala?Lys?Phe?Ser?Ser?Ile?Asp?Thr?Tyr?Gly?Arg?Tyr?Lys?Phe

280 285 290

gaa?aac?caa?cct?atg?atc?ctc?gga?tgg?aac?atg?gcc?cgc?ctc?gta?gaa 1027

Glu?Asn?Gln?Pro?Met?Ile?Leu?Gly?Trp?Asn?Met?Ala?Arg?Leu?Val?Glu

295 300 305

acc?ctc?ctc?cca?ctc?ctg?ggc?gcc?aca?cca?gac?gaa?ggc?atg?aca?gca 1075

Thr?Leu?Leu?Pro?Leu?Leu?Gly?Ala?Thr?Pro?Asp?Glu?Gly?Met?Thr?Ala

310 315 320 325

gcc?caa?gaa?gct?ctc?gta?gaa?ttc?gat?gac?ctc?tgc?gaa?caa?gca?atc 1123

Ala?Gln?Glu?Ala?Leu?Val?Glu?Phe?Asp?Asp?Leu?Cys?Glu?Gln?Ala?Ile

330 335 340

cga?aaa?gaa?ttc?gcc?act?gca?ctg?ggc?ctt?gac?gag?tca?gac?acc?ggc 1171

Arg?Lys?Glu?Phe?Ala?Thr?Ala?Leu?Gly?Leu?Asp?Glu?Ser?Asp?Thr?Gly

345 350 355

acg?gta?gag?cag?ttc?cgt?gaa?ctg?ctc?tac?ctc?cat?aac?ccc?gac?atc 1219

Thr?Val?Glu?Gln?Phe?Arg?Glu?Leu?Leu?Tyr?Leu?His?Asn?Pro?Asp?Ile

360 365 370

acc?acg?ctg?ctg?cgc?gca?ctc?acc?gac?aac?acc?gca?cca?ccg?agt?ggc 1267

Thr?Thr?Leu?Leu?Arg?Ala?Leu?Thr?Asp?Asn?Thr?Ala?Pro?Pro?Ser?Gly

375 380 385

ttt?gaa?gca?ttc?gtt?cac?gac?tgg?aaa?acc?caa?gac?cca?gat?atc?gaa 1315

Phe?Glu?Ala?Phe?Val?His?Asp?Trp?Lys?Thr?Gln?Asp?Pro?Asp?Ile?Glu

390 395 400 405

gca?atg?cga?gca?gta?aat?cca?ctt?ttc?att?cca?cgc?aat?cac?ctc?gtg 1363

Ala?Met?Arg?Ala?Val?Asn?Pro?Leu?Phe?Ile?Pro?Arg?Asn?His?Leu?Val

410 415 420

gaa?gct?gct?ctc?gca?gac?gca?gtt?gaa?ggg?aat?cta?gaa?aag?ttc?cac 1411

Glu?Ala?Ala?Leu?Ala?Asp?Ala?Val?Glu?Gly?Asn?Leu?Glu?Lys?Phe?His

425 430 435

gaa?ctc?ctc?gct?gct?gtc?acc?aat?cct?ttt?gat?cca?act?gcg?ggc?ccc 1459

Glu?Leu?Leu?Ala?Ala?Val?Thr?Asn?Pro?Phe?Asp?Pro?Thr?Ala?Gly?Pro

440 445 450

gat?gaa?cta?cgc?ctg?cca?agc?gaa?gaa?gga?ttt?gaa?gaa?gac?tac?atg 1507

Asp?Glu?Leu?Arg?Leu?Pro?Ser?Glu?Glu?Gly?Phe?Glu?Glu?Asp?Tyr?Met

455 460 465

acc?ttc?tgc?ggt?acc?taggacagat?ggtggggcag?acg 1545

Thr?Phe?Cys?Gly?Thr

470

<210>532

<211>474

<212>PRT

＜213〉Corynebacterium glutamicum

<400>532

Met?Asn?Thr?Ala?Pro?Phe?Lys?Leu?Glu?Ala?Asp?Phe?Ala?Ser?Ala?Leu

1 5 10 15

Pro?Thr?Met?Ala?Ala?Pro?Trp?Gln?Gly?Glu?Glu?Ala?Pro?Asn?Pro?Glu

20 25 30

Leu?Val?Ile?Leu?Asn?Asp?Asp?Leu?Ala?Tyr?Ser?Leu?Gly?Leu?Asp?Pro

35 40 45

Thr?Trp?Leu?Arg?Thr?Pro?Glu?Gly?Val?Gln?Phe?Leu?Leu?Gly?Leu?Asn

50 55 60

Pro?Glu?Pro?Leu?Thr?Lys?Ala?Val?Ala?Gln?Ala?Tyr?Ser?Gly?His?Gln

65 70 75 80

Phe?Gly?Gln?Phe?Val?Ala?Ser?Leu?Gly?Asp?Gly?Arg?Ala?Leu?Leu?Leu

85 90 95

Gly?Glu?Ala?Arg?Ser?Ala?Asp?Gly?Val?Leu?His?Asp?Ile?His?Leu?Lys

100 105 110

Gly?Ser?Gly?Arg?Thr?Gln?Phe?Ser?Arg?Gly?Ala?Asp?Gly?Arg?Ala?Val

115 120 125

Leu?Gly?Pro?Val?Leu?Arg?Glu?Tyr?Ile?Ile?Ser?Glu?Ala?Met?His?Ala

130 135 140

Leu?Gly?Val?Pro?Thr?Thr?Arg?Ser?Leu?Ala?Val?Ile?Ser?Thr?Gly?Arg

145 150 155 160

Lys?Ile?Gln?Arg?Gly?Ser?Val?Ala?Pro?Gly?Ala?Val?Leu?Val?Arg?Val

165 170 175

Ala?Thr?Ser?Leu?Ile?Arg?Val?Gly?Ser?Phe?Gln?Tyr?Ser?Asn?Ile?Ser

180 185 190

Gly?Gly?Ile?Glu?Leu?Ser?Gln?His?Leu?Ala?Asn?Tyr?Thr?Ile?Thr?Arg

195 200 205

His?Phe?Pro?Ser?Leu?Val?Ala?Glu?Leu?Ser?Ala?Pro?Thr?Pro?Ala?Thr

210 215 220

Tyr?Val?Ser?Leu?Phe?Lys?Ala?Ile?Leu?Gln?Arg?Gln?Ala?Asp?Thr?Val

225 230 235 240

Gly?Lys?Trp?Thr?Arg?Leu?Gly?Phe?Val?His?Gly?Ala?Leu?Asn?Thr?Asp

245 250 255

Asn?Thr?Leu?Ile?Ser?Gly?Glu?Thr?Val?Asp?Tyr?Gly?Pro?Cys?Ala?Phe

260 265 270

Met?Glu?Arg?Tyr?Arg?Gly?Asp?Ala?Lys?Phe?Ser?Ser?Ile?Asp?Thr?Tyr

275 280 285

Gly?Arg?Tyr?Lys?Phe?Glu?Asn?Gln?Pro?Met?Ile?Leu?Gly?Trp?Asn?Met

290 295 300

Ala?Arg?Leu?Val?Glu?Thr?Leu?Leu?Pro?Leu?Leu?Gly?Ala?Thr?Pro?Asp

305 310 315 320

Glu?Gly?Met?Thr?Ala?Ala?Gln?Glu?Ala?Leu?Val?Glu?Phe?Asp?Asp?Leu

325 330 335

Cys?Glu?Gln?Ala?Ile?Arg?Lys?Glu?Phe?Ala?Thr?Ala?Leu?Gly?Leu?Asp

340 345 350

Glu?Ser?Asp?Thr?Gly?Thr?Val?Glu?Gln?Phe?Arg?Glu?Leu?Leu?Tyr?Leu

355 360 365

His?Asn?Pro?Asp?Ile?Thr?Thr?Leu?Leu?Arg?Ala?Leu?Thr?Asp?Asn?Thr

370 375 380

Ala?Pro?Pro?Ser?Gly?Phe?Glu?Ala?Phe?Val?His?Asp?Trp?Lys?Thr?Gln

385 390 395 400

Asp?Pro?Asp?Ile?Glu?Ala?Met?Arg?Ala?Val?Asn?Pro?Leu?Phe?Ile?Pro

405 410 415

Arg?Asn?His?Leu?Val?Glu?Ala?Ala?Leu?Ala?Asp?Ala?Val?Glu?Gly?Asn

420 425 430

Leu?Glu?Lys?Phe?His?Glu?Leu?Leu?Ala?Ala?Val?Thr?Asn?Pro?Phe?Asp

435 440 445

Pro?Thr?Ala?Gly?Pro?Asp?Glu?Leu?Arg?Leu?Pro?Ser?Glu?Glu?Gly?Phe

450 455 460

Glu?Glu?Asp?Tyr?Met?Thr?Phe?Cys?Gly?Thr

465 470

<210>533

<211>1236

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1213)

<223>RXC01703

<400>533

gttagacaaa?tgggtaaaca?gagctgacct?agcggaatcc?gccatcaacg?aaaggcattc?60

cgcgagggtt?tggggtctgc?ctcgaacaaa?tcttgggttt?gtg?gca?tgg?cca?tcc 115

Val?Ala?Trp?Pro?Ser

1 5

aac?gcc?aaa?gaa?aaa?ctg?ttt?atc?cac?tgg?cac?tac?tgg?tgg?caa?gcg 163

Asn?Ala?Lys?Glu?Lys?Leu?Phe?Ile?His?Trp?His?Tyr?Trp?Trp?Gln?Ala

10 15 20

cat?tat?cta?gac?tgc?ctg?gtg?gat?gct?gct?cgt?cga?cgc?acc?aca?aag 211

His?Tyr?Leu?Asp?Cys?Leu?Val?Asp?Ala?Ala?Arg?Arg?Arg?Thr?Thr?Lys

25 30 35

gcc?cgt?cgc?gac?cgc?atc?agg?gac?acc?atc?cgc?ggc?att?tcg?gtg?cgc 259

Ala?Arg?Arg?Asp?Arg?Ile?Arg?Asp?Thr?Ile?Arg?Gly?Ile?Ser?Val?Arg

40 45 50

aat?gtg?ggc?aag?ctg?acc?tcg?aat?cgt?tat?tac?gac?gac?aaa?gct?tgg 307

Asn?Val?Gly?Lys?Leu?Thr?Ser?Asn?Arg?Tyr?Tyr?Asp?Asp?Lys?Ala?Trp

55 60 65

ctg?gcc?ctt?gct?ctt?ggg?cgt?gcc?gga?aaa?gtg?cga?aag?gtg?cgc?aca 355

Leu?Ala?Leu?Ala?Leu?Gly?Arg?Ala?Gly?Lys?Val?Arg?Lys?Val?Arg?Thr

70 75 80 85

cca?aaa?tca?ttg?ccc?tcg?ttg?gaa?caa?aac?atc?gtc?gat?ggc?att?gat 403

Pro?Lys?Ser?Leu?Pro?Ser?Leu?Glu?Gln?Asn?Ile?Val?Asp?Gly?Ile?Asp

90 95 100

tcc?ctt?act?ggt?gtg?ctg?ccg?tgg?cgt?tcc?ggc?gaa?acc?ttc?tac?aac 451

Ser?Leu?Thr?Gly?Val?Leu?Pro?Trp?Arg?Ser?Gly?Glu?Thr?Phe?Tyr?Asn

105 110 115

gtt?ccc?tcc?aac?ggt?cct?gct?gcg?atc?atg?atg?gcc?cgc?acc?gac?cgt 499

Val?Pro?Ser?Asn?Gly?Pro?Ala?Ala?Ile?Met?Met?Ala?Arg?Thr?Asp?Arg

120 125 130

ttg?gac?gag?gct?atg?aaa?atc?acc?gat?tgg?att?ttt?gac?aac?ctg?atc 547

Leu?Asp?Glu?Ala?Met?Lys?Ile?Thr?Asp?Trp?Ile?Phe?Asp?Asn?Leu?Ile

135 140 145

gat?ggc?gac?ggc?ctt?gtg?atg?gac?gga?ttg?cgc?atg?cgc?atg?cac?gga 595

Asp?Gly?Asp?Gly?Leu?Val?Met?Asp?Gly?Leu?Arg?Met?Arg?Met?His?Gly

150 155 160 165

cct?gag?ctt?gtc?cgt?tcc?atc?cac?ccg?tat?tgc?caa?ggt?gtc?gcc?att 643

Pro?Glu?Leu?Val?Arg?Ser?Ile?His?Pro?Tyr?Cys?Gln?Gly?Val?Ala?Ile

170 175 180

ggt?gcg?tgt?ttg?gaa?att?gct?ctc?aaa?ctg?cgt?gag?cgc?gca?ggc?ttg 691

Gly?Ala?Cys?Leu?Glu?Ile?Ala?Leu?Lys?Leu?Arg?Glu?Arg?Ala?Gly?Leu

185 190 195

acc?act?act?gtg?gtg?gat?cac?tgg?tcg?gat?gcc?gat?aag?gca?gaa?gac 739

Thr?Thr?Thr?Val?Val?Asp?His?Trp?Ser?Asp?Ala?Asp?Lys?Ala?Glu?Asp

200 205 210

tcc?ctc?aaa?tac?ttt?gca?cac?atc?cac?gct?gtg?gtt?cag?gct?gtg?tcg 787

Ser?Leu?Lys?Tyr?Phe?Ala?His?Ile?His?Ala?Val?Val?Gln?Ala?Val?Ser

215 220 225

cgg?aag?atg?acc?aac?ttc?cac?ggc?gtt?att?gat?tgg?gac?acc?ggt?gac 835

Arg?Lys?Met?Thr?Asn?Phe?His?Gly?Val?Ile?Asp?Trp?Asp?Thr?Gly?Asp

230 235 240 245

ggc?gac?ggc?ggt?ttg?ttc?aag?ggc?att?ttg?gtc?cgc?tat?tta?gct?gat 883

Gly?Asp?Gly?Gly?Leu?Phe?Lys?Gly?Ile?Leu?Val?Arg?Tyr?Leu?Ala?Asp

250 255 260

gtg?gcc?atc?cgc?ctg?cct?gac?gat?tca?cca?acc?aac?cgg?gaa?acc?aaa 931

Val?Ala?Ile?Arg?Leu?Pro?Asp?Asp?Ser?Pro?Thr?Asn?Arg?Glu?Thr?Lys

265 270 275

aag?att?gca?gca?cgc?ctg?gta?ctg?gaa?tcg?gcg?gaa?agc?gta?tgg?aac 979

Lys?Ile?Ala?Ala?Arg?Leu?Val?Leu?Glu?Ser?Ala?Glu?Ser?Val?Trp?Asn

280 285 290

cac?cga?ttg?gaa?gtt?gat?ggc?ctt?ccg?gta?ttc?gcc?aca?gac?tgg?aca 1027

His?Arg?Leu?Glu?Val?Asp?Gly?Leu?Pro?Val?Phe?Ala?Thr?Asp?Trp?Thr

295 300 305

acg?gat?gca?cgc?ctg?cca?caa?aac?ttt?ggt?ttg?agt?tcc?tct?agt?ttg 1075

Thr?Asp?Ala?Arg?Leu?Pro?Gln?Asn?Phe?Gly?Leu?Ser?Ser?Ser?Ser?Leu

310 315 320 325

agc?gat?ctg?gtg?agt?gtt?gtg?cgc?gtg?gat?gaa?cgt?gat?ctg?tcc?gtg 1123

Ser?Asp?Leu?Val?Ser?Val?Val?Arg?Val?Asp?Glu?Arg?Asp?Leu?Ser?Val

330 335 340

caa?ttg?tcc?ggt?tgg?atg?ctc?atg?gaa?gca?gca?gcg?aaa?gtg?gcc?gaa 1171

Gln?Leu?Ser?Gly?Trp?Met?Leu?Met?Glu?Ala?Ala?Ala?Lys?Val?Ala?Glu

345 350 355

gaa?ctg?gaa?aac?aac?ggc?aat?agt?tac?acc?ggt?cgc?tcc?cga 1213

Glu?Leu?Glu?Asn?Asn?Gly?Asn?Ser?Tyr?Thr?Gly?Arg?Ser?Arg

360 365 370

tagccccgat?agtgtatgtg?ctg 1236

<210>534

<211>371

<212>PRT

＜213〉Corynebacterium glutamicum

<400>534

Val?Ala?Trp?Pro?Ser?Asn?Ala?Lys?Glu?Lys?Leu?Phe?Ile?His?Trp?His

1 5 10 15

Tyr?Trp?Trp?Gln?Ala?His?Tyr?Leu?Asp?Cys?Leu?Val?Asp?Ala?Ala?Arg

20 25 30

Arg?Arg?Thr?Thr?Lys?Ala?Arg?Arg?Asp?Arg?Ile?Arg?Asp?Thr?Ile?Arg

35 40 45

Gly?Ile?Ser?Val?Arg?Asn?Val?Gly?Lys?Leu?Thr?Ser?Asn?Arg?Tyr?Tyr

50 55 60

Asp?Asp?Lys?Ala?Trp?Leu?Ala?Leu?Ala?Leu?Gly?Arg?Ala?Gly?Lys?Val

65 70 75 80

Arg?Lys?Val?Arg?Thr?Pro?Lys?Ser?Leu?Pro?Ser?Leu?Glu?Gln?Asn?Ile

85 90 95

Val?Asp?Gly?Ile?Asp?Ser?Leu?Thr?Gly?Val?Leu?Pro?Trp?Arg?Ser?Gly

100 105 110

Glu?Thr?Phe?Tyr?Asn?Val?Pro?Ser?Asn?Gly?Pro?Ala?Ala?Ile?Met?Met

115 120 125

Ala?Arg?Thr?Asp?Arg?Leu?Asp?Glu?Ala?Met?Lys?Ile?Thr?Asp?Trp?Ile

130 135 140

Phe?Asp?Asn?Leu?Ile?Asp?Gly?Asp?Gly?Leu?Val?Met?Asp?Gly?Leu?Arg

145 150 155 160

Met?Arg?Met?His?Gly?Pro?Glu?Leu?Val?Arg?Ser?Ile?His?Pro?Tyr?Cys

165 170 175

Gln?Gly?Val?Ala?Ile?Gly?Ala?Cys?Leu?Glu?Ile?Ala?Leu?Lys?Leu?Arg

180 185 190

Glu?Arg?Ala?Gly?Leu?Thr?Thr?Thr?Val?Val?Asp?His?Trp?Ser?Asp?Ala

195 200 205

Asp?Lys?Ala?Glu?Asp?Ser?Leu?Lys?Tyr?Phe?Ala?His?Ile?His?Ala?Val

210 215 220

Val?Gln?Ala?Val?Ser?Arg?Lys?Met?Thr?Asn?Phe?His?Gly?Val?Ile?Asp

225 230 235 240

Trp?Asp?Thr?Gly?Asp?Gly?Asp?Gly?Gly?Leu?Phe?Lys?Gly?Ile?Leu?Val

245 250 255

Arg?Tyr?Leu?Ala?Asp?Val?Ala?Ile?Arg?Leu?Pro?Asp?Asp?Ser?Pro?Thr

260 265 270

Asn?Arg?Glu?Thr?Lys?Lys?Ile?Ala?Ala?Arg?Leu?Val?Leu?Glu?Ser?Ala

275 280 285

Glu?Ser?Val?Trp?Asn?His?Arg?Leu?Glu?Val?Asp?Gly?Leu?Pro?Val?Phe

290 295 300

Ala?Thr?Asp?Trp?Thr?Thr?Asp?Ala?Arg?Leu?Pro?Gln?Asn?Phe?Gly?Leu

305 310 315 320

Ser?Ser?Ser?Ser?Leu?Ser?Asp?Leu?Val?Ser?Val?Val?Arg?Val?Asp?Glu

325 330 335

Arg?Asp?Leu?Ser?Val?Gln?Leu?Ser?Gly?Trp?Met?Leu?Met?Glu?Ala?Ala

340 345 350

Ala?Lys?Val?Ala?Glu?Glu?Leu?Glu?Asn?Asn?Gly?Asn?Ser?Tyr?Thr?Gly

355 360 365

Arg?Ser?Arg

370

<210>535

<211>800

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(777)

<223>RXC02254

<400>535

atc?gcc?gtt?gcc?gaa?gaa?ggc?gga?ttg?tgg?gaa?aac?ctc?ctg?cag?cac 48

Ile?Ala?Val?Ala?Glu?Glu?Gly?Gly?Leu?Trp?Glu?Asn?Leu?Leu?Gln?His

1 5 10 15

cgc?ttc?ggt?gga?cat?ggt?gcg?cta?gct?ggt?cac?gcc?ttg?gga?aac?ctc 96

Arg?Phe?Gly?Gly?His?Gly?Ala?Leu?Ala?Gly?His?Ala?Leu?Gly?Asn?Leu

20 25 30

gtg?atc?gcg?gcg?ttg?acc?gac?att?ttg?ggc?acc?tcc?cag?cat?gcg?ctt 144

Val?Ile?Ala?Ala?Leu?Thr?Asp?Ile?Leu?Gly?Thr?Ser?Gln?His?Ala?Leu

35 40 45

gat?caa?atc?gct?caa?ctc?gct?gga?gcc?aaa?gga?cgc?atc?atc?ccg?gta 192

Asp?Gln?Ile?Ala?Gln?Leu?Ala?Gly?Ala?Lys?Gly?Arg?Ile?Ile?Pro?Val

50 55 60

tgt?gct?gaa?cct?ttg?gat?ctt?gaa?gcg?gaa?gta?tca?ggt?cta?gac?tct 240

Cys?Ala?Glu?Pro?Leu?Asp?Leu?Glu?Ala?Glu?Val?Ser?Gly?Leu?Asp?Ser

65 70 75 80

gat?gct?cga?gtc?atg?cgt?caa?gtt?cgt?ggt?caa?gtg?gcg?gta?gct?gca 288

Asp?Ala?Arg?Val?Met?Arg?Gln?Val?Arg?Gly?Gln?Val?Ala?Val?Ala?Ala

85 90 95

acc?ccc?ggg?cag?gtg?cga?cgc?gtt?cga?atc?att?ccg?gac?aat?cca?gaa 336

Thr?Pro?Gly?Gln?Val?Arg?Arg?Val?Arg?Ile?Ile?Pro?Asp?Asn?Pro?Glu

100 105 110

ccg?aac?ccc?gct?gcc?atc?gag?gcc?att?ctc?gat?gca?gat?ttg?gtc?acc 384

Pro?Asn?Pro?Ala?Ala?Ile?Glu?Ala?Ile?Leu?Asp?Ala?Asp?Leu?Val?Thr

115 120 125

ctt?ggc?cca?ggt?tcc?tgg?ttc?tcc?tct?gtg?att?cca?cac?att?ttg?gtc 432

Leu?Gly?Pro?Gly?Ser?Trp?Phe?Ser?Ser?Val?Ile?Pro?His?Ile?Leu?Val

130 135 140

cca?ggg?atc?gtt?gat?gcc?ttg?gcg?cag?aca?aaa?gca?acc?aaa?acc?gtg 480

Pro?Gly?Ile?Val?Asp?Ala?Leu?Ala?Gln?Thr?Lys?Ala?Thr?Lys?Thr?Val

145 150 155 160

gtg?tta?aac?ctg?acg?tcc?gag?cca?ggg?gag?acc?gcg?gga?ttc?tct?gca 528

Val?Leu?Asn?Leu?Thr?Ser?Glu?Pro?Gly?Glu?Thr?Ala?Gly?Phe?Ser?Ala

165 170 175

gaa?cga?cac?atc?cat?gtg?ctc?cgc?cag?cat?gct?cga?aac?ctt?cag?gtt 576

Glu?Arg?His?Ile?His?Val?Leu?Arg?Gln?His?Ala?Arg?Asn?Leu?Gln?Val

180 185 190

gac?caa?gtc?att?gtc?gat?gcc?aag?aca?ctg?tcc?tca?caa?acc?gaa?cgc 624

Asp?Gln?Val?Ile?Val?Asp?Ala?Lys?Thr?Leu?Ser?Ser?Gln?Thr?Glu?Arg

195 200 205

aat?cat?gta?gaa?cga?gct?gct?cgc?acc?ctt?ggt?gca?gaa?gtc?tcc?ttc 672

Asn?His?Val?Glu?Arg?Ala?Ala?Arg?Thr?Leu?Gly?Ala?Glu?Val?Ser?Phe

210 215 220

cat?gat?gtc?cag?gct?gaa?gat?ggc?cgt?ggt?cga?ttc?acc?agt?att?cac 720

His?Asp?Val?Gln?Ala?Glu?Asp?Gly?Arg?Gly?Arg?Phe?Thr?Ser?Ile?His

225 230 235 240

gat?cca?gca?aag?ctg?tgt?gca?gcg?ttg?ctg?gca?agt?ttt?gct?gga?gca 768

Asp?Pro?Ala?Lys?Leu?Cys?Ala?Ala?Leu?Leu?Ala?Ser?Phe?Ala?Gly?Ala

245 250 255

cga?aag?cgt?taaggagtag?gcgtgtcact?gac 800

Arg?Lys?Arg

<210>536

<211>259

<212>PRT

＜213〉Corynebacterium glutamicum

<400>536

Ile?Ala?Val?Ala?Glu?Glu?Gly?Gly?Leu?Trp?Glu?Asn?Leu?Leu?Gln?His

1 5 10 15

Arg?Phe?Gly?Gly?His?Gly?Ala?Leu?Ala?Gly?His?Ala?Leu?Gly?Asn?Leu

20 25 30

Val?Ile?Ala?Ala?Leu?Thr?Asp?Ile?Leu?Gly?Thr?Ser?Gln?His?Ala?Leu

35 40 45

Asp?Gln?Ile?Ala?Gln?Leu?Ala?Gly?Ala?Lys?Gly?Arg?Ile?Ile?Pro?Val

50 55 60

Cys?Ala?Glu?Pro?Leu?Asp?Leu?Glu?Ala?Glu?Val?Ser?Gly?Leu?Asp?Ser

65 70 75 80

Asp?Ala?Arg?Val?Met?Arg?Gln?Val?Arg?Gly?Gln?Val?Ala?Val?Ala?Ala

85 90 95

Thr?Pro?Gly?Gln?Val?Arg?Arg?Val?Arg?Ile?Ile?Pro?Asp?Asn?Pro?Glu

100 105 110

Pro?Asn?Pro?Ala?Ala?Ile?Glu?Ala?Ile?Leu?Asp?Ala?Asp?Leu?Val?Thr

115 120 125

Leu?Gly?Pro?Gly?Ser?Trp?Phe?Ser?Ser?Val?Ile?Pro?His?Ile?Leu?Val

130 135 140

Pro?Gly?Ile?Val?Asp?Ala?Leu?Ala?Gln?Thr?Lys?Ala?Thr?Lys?Thr?Val

145 150 155 160

Val?Leu?Asn?Leu?Thr?Ser?Glu?Pro?Gly?Glu?Thr?Ala?Gly?Phe?Ser?Ala

165 170 175

Glu?Arg?His?Ile?His?Val?Leu?Arg?Gln?His?Ala?Arg?Asn?Leu?Gln?Val

180 185 190

Asp?Gln?Val?Ile?Val?Asp?Ala?Lys?Thr?Leu?Ser?Ser?Gln?Thr?Glu?Arg

195 200 205

Asn?His?Val?Glu?Arg?Ala?Ala?Arg?Thr?Leu?Gly?Ala?Glu?Val?Ser?Phe

210 215 220

His?Asp?Val?Gln?Ala?Glu?Asp?Gly?Arg?Gly?Arg?Phe?Thr?Ser?Ile?His

225 230 235 240

Asp?Pro?Ala?Lys?Leu?Cys?Ala?Ala?Leu?Leu?Ala?Ser?Phe?Ala?Gly?Ala

245 250 255

Arg?Lys?Arg

<210>537

<211>1059

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1036)

<223>RXC02255

<400>537

gtgtgcagcg?ttgctggcaa?gttttgctgg?agcacgaaag?cgttaaggag?taggcgtgtc?60

actgacgagt?gatatcaaac?aagaattggc?gcaggtccat?gtg?gcc?aaa?aac?agt 115

Val?Ala?Lys?Asn?Ser

1 5

gtt?cgt?gct?gcg?gaa?gtg?tct?gca?att?tta?agg?ttt?gct?ggt?gag?atg 163

Val?Arg?Ala?Ala?Glu?Val?Ser?Ala?Ile?Leu?Arg?Phe?Ala?Gly?Glu?Met

10 15 20

caa?gct?gtc?ggc?ggc?aag?ctg?gtc?atc?gaa?gca?aat?ttg?gac?agc?atg 211

Gln?Ala?Val?Gly?Gly?Lys?Leu?Val?Ile?Glu?Ala?Asn?Leu?Asp?Ser?Met

25 30 35

caa?gtc?ggt?atg?agg?ctt?cag?gag?ttt?atc?caa?ggt?ttg?tac?aac?tct 259

Gln?Val?Gly?Met?Arg?Leu?Gln?Glu?Phe?Ile?Gln?Gly?Leu?Tyr?Asn?Ser

40 45 50

cga?gtc?gat?gtg?cac?acc?gtg?aac?ccg?act?gtg?agc?agg?aaa?acg?cca 307

Arg?Val?Asp?Val?His?Thr?Val?Asn?Pro?Thr?Val?Ser?Arg?Lys?Thr?Pro

55 60 65

cgg?tat?ttg?gtg?cgc?atc?att?gac?aat?gcc?gat?gaa?att?gcg?cga?cgc 355

Arg?Tyr?Leu?Val?Arg?Ile?Ile?Asp?Asn?Ala?Asp?Glu?Ile?Ala?Arg?Arg

70 75 80 85

acc?gga?ctg?gtc?acc?agg?tct?gga?cat?gtg?gtt?aaa?ggt?cta?gcg?cct 403

Thr?Gly?Leu?Val?Thr?Arg?Ser?Gly?His?Val?Val?Lys?Gly?Leu?Ala?Pro

90 95 100

tct?gtg?gtc?agc?gga?aca?atc?agt?gac?gct?gaa?gct?gca?tgg?cgc?ggt 451

Ser?Val?Val?Ser?Gly?Thr?Ile?Ser?Asp?Ala?Glu?Ala?Ala?Trp?Arg?Gly

105 110 115

gcg?ttt?cta?gcc?aat?gga?tct?tta?agt?gat?cca?ggt?cgt?tcc?tct?tcg 499

Ala?Phe?Leu?Ala?Asn?Gly?Ser?Leu?Ser?Asp?Pro?Gly?Arg?Ser?Ser?Ser

120 125 130

ttg?gag?gtg?ttg?tgt?cct?ggt?caa?gaa?tca?gca?ttg?gca?ctg?gtt?gga 547

Leu?Glu?Val?Leu?Cys?Pro?GIy?Gln?Glu?Ser?Ala?Leu?Ala?Leu?Val?Gly

135 140 145

tgt?gcg?cga?aga?att?ggg?atc?gcg?gcg?aaa?acg?aaa?gat?tct?cga?gga 595

Cys?Ala?Arg?Arg?Ile?Gly?Ile?Ala?Ala?Lys?Thr?Lys?Asp?Ser?Arg?Gly

150 155 160 165

ttt?gat?cgc?gtc?aat?gtt?cgt?gat?gcg?gaa?gca?att?ggg?gca?ctg?ctc 643

Phe?Asp?Arg?Val?Asn?Val?Arg?Asp?Ala?Glu?Ala?Ile?Gly?Ala?Leu?Leu

170 175 180

act?cga?atg?ggt?gcc?cag?aaa?act?cgc?atg?ttg?tgg?gaa?gaa?aaa?cgc 691

Thr?Arg?Met?Gly?Ala?Gln?Lys?Thr?Arg?Met?Leu?Trp?Glu?Glu?Lys?Arg

185 190 195

atc?aag?cgg?gaa?agt?cga?act?ccg?caa?acc?ggg?ttg?gcc?aac?ttc?gac 739

Ile?Lys?Arg?Glu?Ser?Arg?Thr?Pro?Gln?Thr?Gly?Leu?Ala?Asn?Phe?Asp

200 205 210

gat?gcc?aat?ctg?cgc?agg?tca?gcc?cga?gca?gca?gtt?gcc?gct?gca?gcg 787

Asp?Ala?Asn?Leu?Arg?Arg?Ser?Ala?Arg?Ala?Ala?Val?Ala?Ala?Ala?Ala

215 220 225

agg?gta?gaa?cgc?gcc?atg?aag?att?ctt?ggt?gat?gat?gtt?cct?gag?cat 835

Arg?Val?Glu?Arg?Ala?Met?Lys?Ile?Leu?Gly?Asp?Asp?Val?Pro?Glu?His

230 235 240 245

ttg?gct?gag?gct?gga?cag?ctg?cgt?gtg?cag?cac?cgt?cag?gca?tcg?ttg 883

Leu?Ala?Glu?Ala?Gly?Gln?Leu?Arg?Val?Gln?His?Arg?Gln?Ala?Ser?Leu

250 255 260

gag?gag?ttg?ggc?cgg?ttg?gct?gat?cct?caa?atg?acc?aag?gat?gct?gtg 931

Glu?Glu?Leu?Gly?Arg?Leu?Ala?Asp?Pro?Gln?Met?Thr?Lys?Asp?Ala?Val

265 270 275

gcc?ggt?cgt?att?cgt?cgt?ctt?ttg?acg?atg?gca?gat?aag?cgc?gcc?gaa 979

Ala?Gly?Arg?Ile?Arg?Arg?Leu?Leu?Thr?Met?Ala?Asp?Lys?Arg?Ala?Glu

280 285 290

gat?ctg?aag?att?cct?gat?aca?aat?tct?gtt?gtg?acg?gaa?gat?ttg?ttg 1027

Asp?Leu?Lys?Ile?Pro?Asp?Thr?Asn?Ser?Val?Val?Thr?Glu?Asp?Leu?Leu

295 300 305

gaa?gaa?att?tagatgattg?aagcctaaaa?acg 1059

Glu?Glu?Ile

310

<210>538

<211>312

<212>PRT

＜213〉Corynebacterium glutamicum

<400>538

Val?Ala?Lys?Asn?Ser?Val?Arg?Ala?Ala?Glu?Val?Ser?Ala?Ile?Leu?Arg

1 5 10 15

Phe?Ala?Gly?Glu?Met?Gln?Ala?Val?Gly?Gly?Lys?Leu?Val?Ile?Glu?Ala

20 25 30

Asn?Leu?Asp?Ser?Met?Gln?Val?Gly?Met?Arg?Leu?Gln?Glu?Phe?Ile?Gln

35 40 45

Gly?Leu?Tyr?Asn?Ser?Arg?Val?Asp?Val?His?Thr?Val?Asn?Pro?Thr?Val

50 55 60

Ser?Arg?Lys?Thr?Pro?Arg?Tyr?Leu?Val?Arg?Ile?Ile?Asp?Asn?Ala?Asp

65 70 75 80

Glu?Ile?Ala?Arg?Arg?Thr?Gly?Leu?Val?Thr?Arg?Ser?Gly?His?Val?Val

85 90 95

Lys?Gly?Leu?Ala?Pro?Ser?Val?Val?Ser?Gly?Thr?Ile?Ser?Asp?Ala?Glu

100 105 110

Ala?Ala?Trp?Arg?Gly?Ala?Phe?Leu?Ala?Asn?Gly?Ser?Leu?Ser?Asp?Pro

115 120 125

Gly?Arg?Ser?Ser?Ser?Leu?Glu?Val?Leu?Cys?Pro?Gly?Gln?Glu?Ser?Ala

130 135 140

Leu?Ala?Leu?Val?Gly?Cys?Ala?Arg?Arg?Ile?Gly?Ile?Ala?Ala?Lys?Thr

145 150 155 160

Lys?Asp?Ser?Arg?Gly?Phe?Asp?Arg?Val?Asn?Val?Arg?Asp?Ala?Glu?Ala

165 170 175

Ile?Gly?Ala?Leu?Leu?Thr?Arg?Met?Gly?Ala?Gln?Lys?Thr?Arg?Met?Leu

180 185 190

Trp?Glu?Glu?Lys?Arg?Ile?Lys?Arg?Glu?Ser?Arg?Thr?Pro?Gln?Thr?Gly

195 200 205

Leu?Ala?Asn?Phe?Asp?Asp?Ala?Asn?Leu?Arg?Arg?Ser?Ala?Arg?Ala?Ala

210 215 220

Val?Ala?Ala?Ala?Ala?Arg?Val?Glu?Arg?Ala?Met?Lys?Ile?Leu?Gly?Asp

225 230 235 240

Asp?Val?Pro?Glu?His?Leu?Ala?Glu?Ala?Gly?Gln?Leu?Arg?Val?Gln?His

245 250 255

Arg?Gln?Ala?Ser?Leu?Glu?Glu?Leu?Gly?Arg?Leu?Ala?Asp?Pro?Gln?Met

260 265 270

Thr?Lys?Asp?Ala?Val?Ala?Gly?Arg?Ile?Arg?Arg?Leu?Leu?Thr?Met?Ala

275 280 285

Asp?Lys?Arg?Ala?Glu?Asp?Leu?Lys?Ile?Pro?Asp?Thr?Asn?Ser?Val?Val

290 295 300

Thr?Glu?Asp?Leu?Leu?Glu?Glu?Ile

305 310

<210>539

<211>681

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(658)

<223>RXC02435

<400>539

tcatgaatgt?agaacggatt?tatcgacaag?cgccagcaag?tacgttgatc?tctttagcca?60

tcatcgctgt?gtacgcagtg?cggccattca?atcgagatca?gtg?aca?gac?aac?ctg 115

Val?Thr?Asp?Asn?Leu

1 5

ggt?tca?acc?agt?atc?ggt?gac?gcg?tgg?att?ctg?tac?gca?ccg?ctg?atg 163

Gly?Ser?Thr?Ser?Ile?Gly?Asp?Ala?Trp?Ile?Leu?Tyr?Ala?Pro?Leu?Met

10 15 20

gat?gat?ggt?ggc?ttt?ggt?cca?ctg?cgt?gcc?atc?gga?gga?atg?ttc?ctg 211

Asp?Asp?Gly?Gly?Phe?Gly?Pro?Leu?Arg?Ala?Ile?Gly?Gly?Met?Phe?Leu

25 30 35

cac?att?ggc?ccc?ggg?cac?atg?ctg?ttg?aac?ctt?gtg?ttg?ttg?tgg?ttg 259

His?Ile?Gly?Pro?Gly?His?Met?Leu?Leu?Asn?Leu?Val?Leu?Leu?Trp?Leu

40 45 50

ctg?gga?aga?gaa?att?gaa?cga?gac?ttc?ggt?tct?gcg?ctt?ttc?act?gcg 307

Leu?Gly?Arg?Glu?Ile?Glu?Arg?Asp?Phe?Gly?Ser?Ala?Leu?Phe?Thr?Ala

55 60 65

atg?tac?ttt?gtg?ggc?ggt?att?ggt?gcg?tct?gca?gct?gtc?atc?tgg?atg 355

Met?Tyr?Phe?Val?Gly?Gly?Ile?Gly?Ala?Ser?Ala?Ala?Val?Ile?Trp?Met

70 75 80 85

gat?ccc?tat?tca?ccg?aca?gca?ggt?gct?tcc?ggc?gcc?att?tac?gcc?atg 403

Asp?Pro?Tyr?Ser?Pro?Thr?Ala?Gly?Ala?Ser?Gly?Ala?Ile?Tyr?Ala?Met

90 95 100

atg?gct?att?ttg?gtg?ggg?ctt?ttt?gtg?tta?aga?agc?gcg?gat?atc?cga 451

Met?Ala?Ile?Leu?Val?Gly?Leu?Phe?Val?Leu?Arg?Ser?Ala?Asp?Ile?Arg

105 110 115

gca?ccc?ttg?atc?ctt?atc?gcc?atc?aac?atc?gcc?tat?acc?ttg?atg?tcc 499

Ala?Pro?Leu?Ile?Leu?Ile?Ala?Ile?Asn?Ile?Ala?Tyr?Thr?Leu?Met?Ser

120 125 130

acc?aat?gtt?tct?ctg?tgg?gga?cac?ctt?gga?ggt?ttg?atc?act?gga?gct 547

Thr?Asn?Val?Ser?Leu?Trp?Gly?His?Leu?Gly?Gly?Leu?Ile?Thr?GIy?Ala

135 140 145

tta?att?act?tgg?cca?atg?gtt?aaa?gcg?aaa?act?caa?aga?aca?cgg?tgg 595

Leu?Ile?Thr?Trp?Pro?Met?Val?Lys?Ala?Lys?Thr?Gln?Arg?Thr?Arg?Trp

150 155 160 165

att?atc?gtg?ctc?att?ggt?ttt?gct?gta?gtt?gtg?gct?gct?gtc?att?cta 643

Ile?Ile?Val?Leu?Ile?Gly?Phe?Ala?Val?Val?Val?Ala?Ala?Val?Ile?Leu

170 175 180

gga?att?gac?cgg?gtg?tagacacatt?ccgcccattg?ccc 681

Gly?Ile?Asp?Arg?Val

185

<210>540

<211>186

<212>PRT

＜213〉Corynebacterium glutamicum

<400>540

Val?Thr?Asp?Asn?Leu?Gly?Ser?Thr?Ser?Ile?Gly?Asp?Ala?Trp?Ile?Leu

1 5 10 15

Tyr?Ala?Pro?Leu?Met?Asp?Asp?Gly?Gly?Phe?Gly?Pro?Leu?Arg?Ala?Ile

20 25 30

Gly?Gly?Met?Phe?Leu?His?Ile?Gly?Pro?Gly?His?Met?Leu?Leu?Asn?Leu

35 40 45

Val?Leu?Leu?Trp?Leu?Leu?Gly?Arg?Glu?Ile?Glu?Arg?Asp?Phe?Gly?Ser

50 55 60

Ala?Leu?Phe?Thr?Ala?Met?Tyr?Phe?Val?Gly?Gly?Ile?Gly?Ala?Ser?Ala

65 70 75 80

Ala?Val?Ile?Trp?Met?Asp?Pro?Tyr?Ser?Pro?Thr?Ala?Gly?Ala?Ser?Gly

85 90 95

Ala?Ile?Tyr?Ala?Met?Met?Ala?Ile?Leu?Val?Gly?Leu?Phe?Val?Leu?Arg

100 105 110

Ser?Ala?Asp?Ile?Arg?Ala?Pro?Leu?Ile?Leu?Ile?Ala?Ile?Asn?Ile?Ala

115 120 125

Tyr?Thr?Leu?Met?Ser?Thr?Asn?Val?Ser?Leu?Trp?Gly?His?Leu?Gly?Gly

130 135 140

Leu?Ile?Thr?Gly?Ala?Leu?Ile?Thr?Trp?Pro?Met?Val?Lys?Ala?Lys?Thr

145 150 155 160

Gln?Arg?Thr?Arg?Trp?Ile?Ile?Val?Leu?Ile?Gly?Phe?Ala?Val?Val?Val

165 170 175

Ala?Ala?Val?Ile?Leu?Gly?Ile?Asp?Arg?Val

180 185

<210>541

<211>681

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(658)

<223>FRXA02435

<400>541

tcatgaatgt?agaacggatt?tatcgacaag?cgccagcaag?tacgttgatc?tctttagcca?60

tcatcgctgt?gtacgcagtg?cggccattca?atcgagatca?gtg?aca?gac?aac?ctg 115

Val?Thr?Asp?Asn?Leu

1 5

ggt?tca?acc?agt?atc?ggt?gac?gcg?tgg?att?ctg?tac?gca?ccg?ctg?atg 163

Gly?Ser?Thr?Ser?Ile?Gly?Asp?Ala?Trp?Ile?Leu?Tyr?Ala?Pro?Leu?Met

10 15 20

gat?gat?ggt?ggc?ttt?ggt?cca?ctg?cgt?gcc?atc?gga?gga?atg?ttc?ctg 211

Asp?Asp?Gly?Gly?Phe?Gly?Pro?Leu?Arg?Ala?Ile?Gly?Gly?Met?Phe?Leu

25 30 35

cac?att?ggc?ccc?ggg?cac?atg?ctg?ttg?aac?ctt?gtg?ttg?ttg?tgg?ttg 259

His?Ile?Gly?Pro?Gly?His?Met?Leu?Leu?Asn?Leu?Val?Leu?Leu?Trp?Leu

40 45 50

ctg?gga?aga?gaa?att?gaa?cga?gac?ttc?ggt?tct?gcg?ctt?ttc?act?gcg 307

Leu?Gly?Arg?Glu?Ile?Glu?Arg?Asp?Phe?Gly?Ser?Ala?Leu?Phe?Thr?Ala

55 60 65

atg?tac?ttt?gtg?ggc?ggt?att?ggt?gcg?tct?gca?gct?gtc?atc?tgg?atg 355

Met?Tyr?Phe?Val?Gly?Gly?Ile?Gly?Ala?Ser?Ala?Ala?Val?Ile?Trp?Met

70 75 80 85

gat?ccc?tat?tca?ccg?aca?gca?ggt?gct?tcc?ggc?gcc?att?tac?gcc?atg 403

Asp?Pro?Tyr?Ser?Pro?Thr?Ala?Gly?Ala?Ser?Gly?Ala?Ile?Tyr?Ala?Met

90 95 100

atg?gct?att?ttg?gtg?ggg?ctt?ttt?gtg?tta?aga?agc?gcg?gat?atc?cga 451

Met?Ala?Ile?Leu?Val?Gly?Leu?Phe?Val?Leu?Arg?Ser?Ala?Asp?Ile?Arg

105 110 115

gca?ccc?ttg?atc?ctt?atc?gcc?atc?aac?atc?gcc?tat?acc?ttg?atg?tcc 499

Ala?Pro?Leu?Ile?Leu?Ile?Ala?Ile?Asn?Ile?Ala?Tyr?Thr?Leu?Met?Ser

120 125 130

acc?aat?gtt?tct?ctg?tgg?gga?cac?ctt?gga?ggt?ttg?atc?act?gga?gct 547

Thr?Asn?Val?Ser?Leu?Trp?Gly?His?Leu?Gly?Gly?Leu?Ile?Thr?Gly?Ala

135 140 145

tta?att?act?tgg?cca?atg?gtt?aaa?gcg?aaa?act?caa?aga?aca?cgg?tgg 595

Leu?Ile?Thr?Trp?Pro?Met?Val?Lys?Ala?Lys?Thr?Gln?Arg?Thr?Arg?Trp

150 155 160 165

att?atc?gtg?ctc?att?ggt?ttt?gct?gta?gtt?gtg?gct?gct?gtc?att?cta 643

Ile?Ile?Val?Leu?Ile?Gly?Phe?Ala?Val?Val?Val?Ala?Ala?Val?Ile?Leu

170 175 180

gga?att?gac?cgg?gtg?tagacacatt?ccgcccattg?ccc 681

Gly?Ile?Asp?Arg?Val

185

<210>542

<211>186

<212>PRT

＜213〉Corynebacterium glutamicum

<400>?542

Val?Thr?Asp?Asn?Leu?Gly?Ser?Thr?Ser?Ile?Gly?Asp?Ala?Trp?Ile?Leu

1 5 10 15

Tyr?Ala?Pro?Leu?Met?Asp?Asp?Gly?Gly?Phe?Gly?Pro?Leu?Arg?Ala?Ile

20 25 30

Gly?Gly?Met?Phe?Leu?His?Ile?Gly?Pro?Gly?His?Met?Leu?Leu?Asn?Leu

35 40 45

Val?Leu?Leu?Trp?Leu?Leu?Gly?Arg?Glu?Ile?Glu?Arg?Asp?Phe?Gly?Ser

50 55 60

Ala?Leu?Phe?Thr?Ala?Met?Tyr?Phe?Val?Gly?Gly?Ile?Gly?Ala?Ser?Ala

65 70 75 80

Ala?Val?Ile?Trp?Met?Asp?Pro?Tyr?Ser?Pro?Thr?Ala?Gly?Ala?Ser?Gly

85 90 95

Ala?Ile?Tyr?Ala?Met?Met?Ala?Ile?Leu?Val?Gly?Leu?Phe?Val?Leu?Arg

100 105 110

Ser?Ala?Asp?Ile?Arg?Ala?Pro?Leu?Ile?Leu?Ile?Ala?Ile?Asn?Ile?Ala

115 120 125

Tyr?Thr?Leu?Met?Ser?Thr?Asn?Val?Ser?Leu?Trp?Gly?His?Leu?Gly?Gly

130 135 140

Leu?Ile?Thr?Gly?Ala?Leu?Ile?Thr?Trp?Pro?Met?Val?Lys?Ala?Lys?Thr

145 150 155 160

Gln?Arg?Thr?Arg?Trp?Ile?Ile?Val?Leu?Ile?Gly?Phe?Ala?Val?Val?Val

165 170 175

Ala?Ala?Val?Ile?Leu?Gly?Ile?Asp?Arg?Val

180 185

<210>543

<211>1141

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1111)

<223>RXC03216

<400>543

gctgtatcac?agtcagctgc?agcaggtggc?gaaaccgttg?cggtcccagc?ggctgctctg?60

atccctgcaa?acaactagaa?actattcaga?aagcatcacc?atg?aaa?ctc?ggt?ctc 115

Met?Lys?Leu?Gly?Leu

1 5

tac?aac?gcg?atc?ttc?cac?gac?cgc?acc?ctg?cca?gaa?gcg?ctc?gca?gcc 163

Tyr?Asn?Ala?Ile?Phe?His?Asp?Arg?Thr?Leu?Pro?Glu?Ala?Leu?Ala?Ala

10 15 20

atc?aaa?gct?gca?ggt?ctc?acc?gga?att?gaa?ctc?aac?acc?ggc?gga?ttt 211

Ile?Lys?Ala?Ala?Gly?Leu?Thr?Gly?Ile?Glu?Leu?Asn?Thr?Gly?Gly?Phe

25 30 35

ttg?cct?gca?acc?cac?atc?ccg?acc?atc?gat?gac?atc?ctg?gtc?agc?gat 259

Leu?Pro?Ala?Thr?His?Ile?Pro?Thr?Ile?Asp?Asp?Ile?Leu?Val?Ser?Asp

40 45 50

gat?gcc?cgc?gat?gaa?ttc?ctc?ggg?att?ttc?gaa?ggc?acc?ggc?gtc?gac 307

Asp?Ala?Arg?Asp?Glu?Phe?Leu?Gly?Ile?Phe?Glu?Gly?Thr?Gly?Val?Asp

55 60 65

atc?tac?ggc?ctt?aac?tgc?aac?ggc?aac?ccg?ctt?cac?ccc?aac?aag?gcg 355

Ile?Tyr?Gly?Leu?Asn?Cys?Asn?Gly?Asn?Pro?Leu?His?Pro?Asn?Lys?Ala

70 75 80 85

atc?ggg?gac?aag?cat?gcc?gaa?gac?att?cga?cgt?tcc?atc?cgc?ctc?gca 403

Ile?Gly?Asp?Lys?His?Ala?Glu?Asp?Ile?Arg?Arg?Ser?Ile?Arg?Leu?Ala

90 95 100

gag?cgc?ctc?ggc?caa?aac?cgt?gtg?gtc?acc?atg?tct?ggt?ctt?cct?ggt 451

Glu?Arg?Leu?Gly?Gln?Asn?Arg?Val?Val?Thr?Met?Ser?Gly?Leu?Pro?Gly

105 110 115

ggc?gaa?cca?ggc?gcg?aag?tac?acc?aac?tgg?gtt?gtc?aac?gcg?tgg?aac 499

Gly?Glu?Pro?Gly?Ala?Lys?Tyr?Thr?Asn?Trp?Val?Val?Asn?Ala?Trp?Asn

120 125 130

tcc?gca?gcc?ttg?gat?gtc?ctt?gat?tac?caa?tgg?gat?atc?gca?gct?gaa 547

Ser?Ala?Ala?Leu?Asp?Val?Leu?Asp?Tyr?Gln?Trp?Asp?Ile?Ala?Ala?Glu

135 140 145

ttc?tgg?cgc?gag?acc?gac?cgc?ttc?gcc?gca?gat?cac?ggc?gtg?aaa?gtg 595

Phe?Trp?Arg?Glu?Thr?Asp?Arg?Phe?Ala?Ala?Asp?His?Gly?Val?Lys?Val

150 155 160 165

gct?ctt?gag?ctg?cac?cca?cag?aac?atc?gtg?ttc?aac?tcc?gct?gac?gtg 643

Ala?Leu?Glu?Leu?His?Pro?Gln?Asn?Ile?Val?Phe?Asn?Ser?Ala?Asp?Val

170 175 180

cat?aag?ctc?atc?gat?ctc?acc?ggc?gcc?acc?cac?gtg?ggc?gtc?gaa?ctg 691

His?Lys?Leu?Ile?Asp?Leu?Thr?Gly?Ala?Thr?His?Val?Gly?Val?Glu?Leu

185 190 195

gat?gca?tca?cac?ctg?ttc?tgg?cag?cag?atg?gac?cca?atc?gct?gtg?att 739

Asp?Ala?Ser?His?Leu?Phe?Trp?Gln?Gln?Met?Asp?Pro?Ile?Ala?Val?Ile

200 205 210

gat?cac?ctc?ggc?gag?ctc?atc?ttc?cac?gcc?gcc?gcc?aaa?gac?gtg?cga 787

Asp?His?Leu?Gly?Glu?Leu?Ile?Phe?His?Ala?Ala?Ala?Lys?Asp?Val?Arg

215 220 225

gtt?aat?aag?gaa?tgg?gct?cag?ctc?aac?ggt?gtg?ctg?gac?aac?agc?ttc 835

Val?Asn?Lys?Glu?Trp?Ala?Gln?Leu?Asn?Gly?Val?Leu?Asp?Asn?Ser?Phe

230 235 240 245

cga?cgc?ctt?gac?cca?tcc?gaa?aac?cgc?acc?aac?ttg?ggc?ggc?gac?gag 883

Arg?Arg?Leu?Asp?Pro?Ser?Glu?Asn?Arg?Thr?Asn?Leu?Gly?Gly?Asp?Glu

250 255 260

tgg?gcg?aat?gaa?tgg?cca?aag?aac?tct?gct?tgg?gat?ttc?gtt?gct?ctg 931

Trp?Ala?Asn?Glu?Trp?Pro?Lys?Asn?Ser?Ala?Trp?Asp?Phe?Val?Ala?Leu

265 270 275

ggc?cgc?ggt?cat?gac?gtt?gct?tac?tgg?acc?gaa?ttc?ctc?cgc?gca?ctt 979

Gly?Arg?Gly?His?Asp?Val?Ala?Tyr?Trp?Thr?Glu?Phe?Leu?Arg?Ala?Leu

280 285 290

cac?cgc?gtc?gat?cca?aac?atg?ctg?gtc?aac?atc?gaa?cac?gag?gat?gtt 1027

His?Arg?Val?Asp?Pro?Asn?Met?Leu?Val?Asn?Ile?Glu?His?Glu?Asp?Val

295 300 305

tca?ctc?ggt?cgc?gaa?gaa?ggc?gtc?aac?gaa?gcc?gct?aag?gtg?ctg?atc 1075

Ser?Leu?Gly?Arg?Glu?Glu?Gly?Val?Asn?Glu?Ala?Ala?Lys?Val?Leu?Ile

310 315 320 325

gag?gcc?aac?aag?gca?ctc?gaa?gag?tcc?ctg?gtt?tct?taaaaaaact 1121

Glu?Ala?Asn?Lys?Ala?Leu?Glu?Glu?Ser?Leu?Val?Ser

330 335

acgcctgccc?cgcaacgctt 1141

<210>544

<211>337

<212>PRT

＜213〉Corynebacterium glutamicum

<400>?544

Met?Lys?Leu?Gly?Leu?Tyr?Asn?Ala?Ile?Phe?His?Asp?Arg?Thr?Leu?Pro

1 5 10 15

Glu?Ala?Leu?Ala?Ala?Ile?Lys?Ala?Ala?Gly?Leu?Thr?Gly?Ile?Glu?Leu

20 25 30

Asn?Thr?Gly?Gly?Phe?Leu?Pro?Ala?Thr?His?Ile?Pro?Thr?Ile?Asp?Asp

35 40 45

Ile?Leu?Val?Ser?Asp?Asp?Ala?Arg?Asp?Glu?Phe?Leu?Gly?Ile?Phe?Glu

50 55 60

Gly?Thr?Gly?Val?Asp?Ile?Tyr?Gly?Leu?Asn?Cys?Asn?Gly?Asn?Pro?Leu

65 70 75 80

His?Pro?Asn?Lys?Ala?Ile?Gly?Asp?Lys?His?Ala?Glu?Asp?Ile?Arg?Arg

85 90 95

Ser?Ile?Arg?Leu?Ala?Glu?Arg?Leu?Gly?Gln?Asn?Arg?Val?Val?Thr?Met

100 105 110

Ser?Gly?Leu?Pro?Gly?Gly?Glu?Pro?Gly?Ala?Lys?Tyr?Thr?Asn?Trp?Val

115 120 125

Val?Asn?Ala?Trp?Asn?Ser?Ala?Ala?Leu?Asp?Val?Leu?Asp?Tyr?Gln?Trp

130 135 140

Asp?Ile?Ala?Ala?Glu?Phe?Trp?Arg?Glu?Thr?Asp?Arg?Phe?Ala?Ala?Asp

145 150 155 160

His?Gly?Val?Lys?Val?Ala?Leu?Glu?Leu?His?Pro?Gln?Asn?Ile?Val?Phe

165 170 175

Asn?Ser?Ala?Asp?Val?His?Lys?Leu?Ile?Asp?Leu?Thr?Gly?Ala?Thr?His

180 185 190

Val?Gly?Val?Glu?Leu?Asp?Ala?Ser?His?Leu?Phe?Trp?Gln?Gln?Met?Asp

195 200 205

Pro?Ile?Ala?Val?Ile?Asp?His?Leu?Gly?Glu?Leu?Ile?Phe?His?Ala?Ala

210 215 220

Ala?Lys?Asp?Val?Arg?Val?Asn?Lys?Glu?Trp?Ala?Gln?Leu?Asn?Gly?Val

225 230 235 240

Leu?Asp?Asn?Ser?Phe?Arg?Arg?Leu?Asp?Pro?Ser?Glu?Asn?Arg?Thr?Asn

245 250 255

Leu?Gly?Gly?Asp?Glu?Trp?Ala?Asn?Glu?Trp?Pro?Lys?Asn?Ser?Ala?Trp

260 265 270

Asp?Phe?Val?Ala?Leu?Gly?Arg?Gly?His?Asp?Val?Ala?Tyr?Trp?Thr?Glu

275 280 285

Phe?Leu?Arg?Ala?Leu?His?Arg?Val?Asp?Pro?Asn?Met?Leu?Val?Asn?Ile

290 295 300

Glu?His?Glu?Asp?Val?Ser?Leu?Gly?Arg?Glu?Glu?Gly?Val?Asn?Glu?Ala

305 310 315 320

Ala?Lys?Val?Leu?Ile?Glu?Ala?Asn?Lys?Ala?Leu?Glu?Glu?Ser?Leu?Val

325 330 335

Ser

<210>545

<211>1416

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1393)

<223>RXA02175

<400>545

tgacatgcgc?ttggcgcatc?ccagttggta?agaataaacg?ggactacttc?cgtaatccgg?60

aagagttttt?ttccgaacaa?atatgtttga?aagggatatc?gtg?gct?act?gat?aac 115

Val?Ala?Thr?Asp?Asn

1 5

aac?aag?gct?gtc?etg?cac?tac?ccc?ggt?ggc?gag?ttc?gaa?atg?gac?atc 163

Asn?Lys?Ala?Val?Leu?His?Tyr?Pro?Gly?Gly?Glu?Phe?Glu?Met?Asp?Ile

10 15 20

atc?gag?gct?tct?gag?ggt?aac?aac?ggt?gtt?gtc?ctg?ggc?aag?atg?ctg 211

Ile?Glu?Ala?Ser?Glu?Gly?Asn?Asn?Gly?Val?Val?Leu?Gly?Lys?Met?Leu

25 30 35

tct?gag?act?gga?ctg?atc?act?ttt?gac?cca?ggt?tat?gtg?agc?act?ggc 259

Ser?Glu?Thr?Gly?Leu?Ile?Thr?Phe?Asp?Pro?Gly?Tyr?Val?Ser?Thr?Gly

40 45 50

tcc?acc?gag?tcg?aag?atc?acc?tac?atc?gat?ggc?gat?gcg?gga?atc?ctg 307

Ser?Thr?Glu?Ser?Lys?Ile?Thr?Tyr?Ile?Asp?Gly?Asp?Ala?Gly?Ile?Leu

55 60 65

cgt?tac?cgc?ggc?tat?gac?atc?gct?gat?ctg?gct?gag?aat?gcc?acc?ttc 355

Arg?Tyr?Arg?Gly?Tyr?Asp?Ile?Ala?Asp?Leu?Ala?Glu?Asn?Ala?Thr?Phe

70 75 80 85

aac?gag?gtt?tct?tac?cta?ctt?atc?aac?ggt?gag?cta?cca?acc?cca?gat 403

Asn?Glu?Val?Ser?Tyr?Leu?Leu?Ile?Asn?Gly?Glu?Leu?Pro?Thr?Pro?Asp

90 95 100

gag?ctt?cac?aag?ttt?aac?gac?gag?att?cgc?cac?cac?acc?ctt?ctg?gac 451

Glu?Leu?His?Lys?Phe?Asn?Asp?Glu?Ile?Arg?His?His?Thr?Leu?Leu?Asp

105 110 115

gag?gac?ttc?aag?tcc?cag?ttc?aac?gtg?ttc?cca?cgc?gac?gct?cac?cca 499

Glu?Asp?Phe?Lys?Ser?Gln?Phe?Asn?Val?Phe?Pro?Arg?Asp?Ala?His?Pro

120 125 130

atg?gca?acc?ttg?gct?tcc?tcg?gtt?aac?att?ttg?tct?acc?tac?tac?cag 547

Met?Ala?Thr?Leu?Ala?Ser?Ser?Val?Asn?Ile?Leu?Ser?Thr?Tyr?Tyr?Gln

135 140 145

gac?cag?ctg?aac?cca?ctc?gat?gag?gca?cag?ctt?gat?aag?gca?acc?gtt 595

Asp?Gln?Leu?Asn?Pro?Leu?Asp?Glu?Ala?Gln?Leu?Asp?Lys?Ala?Thr?Val

150 155 160 165

cgc?ctc?atg?gca?aag?gtt?cca?atg?ctg?gct?gcg?tac?gca?cac?cgc?gca 643

Arg?Leu?Met?Ala?Lys?Val?Pro?Met?Leu?Ala?Ala?Tyr?Ala?His?Arg?Ala

170 175 180

cgc?aag?ggt?gct?cct?tac?atg?tac?cca?gac?aac?tcc?ctc?aat?gcg?cgt 691

Arg?Lys?Gly?Ala?Pro?Tyr?Met?Tyr?Pro?Asp?Asn?Ser?Leu?Asn?Ala?Arg

185 190 195

gag?aac?ttc?ctg?cgc?atg?atg?ttc?ggt?tac?cca?acc?gag?cca?tac?gag 739

Glu?Asn?Phe?Leu?Arg?Met?Met?Phe?Gly?Tyr?Pro?Thr?Glu?Pro?Tyr?Glu

200 205 210

atc?gac?cca?atc?atg?gtc?aag?gct?ctg?gac?aag?ctg?ctc?atc?ctg?cac 787

Ile?Asp?Pro?Ile?Met?Val?Lys?Ala?Leu?Asp?Lys?Leu?Leu?Ile?Leu?His

215 220 225

gct?gac?cac?gag?cag?aac?tgc?tcc?acc?tcc?acc?gtt?cgt?atg?atc?ggt 835

Ala?Asp?His?Glu?Gln?Asn?Cys?Ser?Thr?Ser?Thr?Val?Arg?Met?Ile?Gly

230 235 240 245

tcc?gca?cag?gcc?aac?atg?ttt?gtc?tcc?atc?gct?ggt?ggc?atc?aac?gct 883

Ser?Ala?Gln?Ala?Asn?Met?Phe?Val?Ser?Ile?Ala?Gly?Gly?Ile?Asn?Ala

250 255 260

ctg?tcc?ggc?cca?ctg?cac?ggt?ggc?gca?aac?cag?gct?gtt?ctg?gag?atg 931

Leu?Ser?Gly?Pro?Leu?His?Gly?Gly?Ala?Asn?Gln?Ala?Val?Leu?Glu?Met

265 270 275

ctc?gaa?gac?atc?aag?agc?aac?cac?ggt?ggc?gac?gca?acc?gag?ttc?atg 979

Leu?Glu?Asp?Ile?Lys?Ser?Asn?His?Gly?Gly?Asp?Ala?Thr?Glu?Phe?Met

280 285 290

aac?aag?gtc?aag?aac?aag?gaa?gac?ggc?gtc?cgc?ctc?atg?ggc?ttc?gga 1027

Asn?Lys?Val?Lys?Asn?Lys?Glu?Asp?Gly?Val?Arg?Leu?Met?Gly?Phe?Gly

295 300 305

cac?cgc?gtt?tac?aag?aac?tac?gat?cca?cgt?gca?gca?atc?gtc?aag?gag 1075

His?Arg?Val?Tyr?Lys?Asn?Tyr?Asp?Pro?Arg?Ala?Ala?Ile?Val?Lys?Glu

310 315 320 325

acc?gca?cac?gag?atc?ctc?gag?cac?ctc?ggt?ggc?gac?gat?ctt?ctg?gat 1123

Thr?Ala?His?Glu?Ile?Leu?Glu?His?Leu?Gly?Gly?Asp?Asp?Leu?Leu?Asp

330 335 340

ctg?gca?atc?aag?ctg?gaa?gaa?att?gca?ctg?gct?gat?gat?tac?ttc?atc 1171

Leu?Ala?Ile?Lys?Leu?Glu?Glu?Ile?Ala?Leu?Ala?Asp?Asp?Tyr?Phe?Ile

345 350 355

tcc?cgc?aag?ctc?tac?ccg?aac?gta?gac?ttc?tac?acc?ggc?ctg?atc?tac 1219

Ser?Arg?Lys?Leu?Tyr?Pro?Asn?Val?Asp?Phe?Tyr?Thr?Gly?Leu?Ile?Tyr

360 365 370

cgc?gca?atg?ggc?ttc?cca?act?gac?ttc?ttc?acc?gta?ttg?ttc?gca?atc 1267

Arg?Ala?Met?Gly?Phe?Pro?Thr?Asp?Phe?Phe?Thr?Val?Leu?Phe?Ala?Ile

375 380 385

ggt?cgt?ctg?cca?gga?tgg?atc?gct?cac?tac?cgc?gag?cag?ctc?ggt?gca 1315

Gly?Arg?Leu?Pro?Gly?Trp?Ile?Ala?His?Tyr?Arg?Glu?Gln?Leu?Gly?Ala

390 395 400 405

gca?ggc?aac?aag?atc?aac?cgc?cca?cgc?cag?gtc?tac?acc?ggc?aac?gaa 1363

Ala?Gly?Asn?Lys?Ile?Asn?Arg?Pro?Arg?Gln?Val?Tyr?Thr?Gly?Asn?Glu

410 415 420

tcc?cgc?aag?ttg?gtt?cct?cgc?gag?gag?cgc?taaatttagc?ggatgattct 1413

Ser?Arg?Lys?Leu?Val?Pro?Arg?Glu?Glu?Arg

425 430

cgt 1416

<210>546

<211>431

<212>PRT

＜213〉Corynebacterium glutamicum

<400>546

Val?Ala?Thr?Asp?Asn?Asn?Lys?Ala?Val?Leu?His?Tyr?Pro?Gly?Gly?Glu

1 5 10 15

Phe?Glu?Met?Asp?Ile?Ile?Glu?Ala?Ser?Glu?Gly?Asn?Asn?Gly?Val?Val

20 25 30

Leu?Gly?Lys?Met?Leu?Ser?Glu?Thr?Gly?Leu?Ile?Thr?Phe?Asp?Pro?Gly

35 40 45

Tyr?Val?Ser?Thr?Gly?Ser?Thr?Glu?Ser?Lys?Ile?Thr?Tyr?Ile?Asp?Gly

50 55 60

Asp?Ala?Gly?Ile?Leu?Arg?Tyr?Arg?Gly?Tyr?Asp?Ile?Ala?Asp?Leu?Ala

65 70 75 80

Glu?Asn?Ala?Thr?Phe?Asn?Glu?Val?Ser?Tyr?Leu?Leu?Ile?Asn?Gly?Glu

85 90 95

Leu?Pro?Thr?Pro?Asp?Glu?Leu?His?Lys?Phe?Asn?Asp?Glu?Ile?Arg?His

100 105 110

His?Thr?Leu?Leu?Asp?Glu?Asp?Phe?Lys?Ser?Gln?Phe?Asn?Val?Phe?Pro

115 120 125

Arg?Asp?Ala?His?Pro?Met?Ala?Thr?Leu?Ala?Ser?Ser?Val?Asn?Ile?Leu

130 135 140

Ser?Thr?Tyr?Tyr?Gln?Asp?Gln?Leu?Asn?Pro?Leu?Asp?Glu?Ala?Gln?Leu

145 150 155 160

Asp?Lys?Ala?Thr?Val?Arg?Leu?Met?Ala?Lys?Val?Pro?Met?Leu?Ala?Ala

165 170 175

Tyr?Ala?His?Arg?Ala?Arg?Lys?Gly?Ala?Pro?Tyr?Met?Tyr?Pro?Asp?Asn

180 185 190

Ser?Leu?Asn?Ala?Arg?Glu?Asn?Phe?Leu?Arg?Met?Met?Phe?Gly?Tyr?Pro

195 200 205

Thr?Glu?Pro?Tyr?Glu?Ile?Asp?Pro?Ile?Met?Val?Lys?Ala?Leu?Asp?Lys

210 215 220

Leu?Leu?Ile?Leu?His?Ala?Asp?His?Glu?Gln?Asn?Cys?Ser?Thr?Ser?Thr

225 230 235 240

Val?Arg?Met?Ile?Gly?Ser?Ala?Gln?Ala?Asn?Met?Phe?Val?Ser?Ile?Ala

245 250 255

Gly?Gly?Ile?Asn?Ala?Leu?Ser?Gly?Pro?Leu?His?Gly?Gly?Ala?Asn?Gln

260 265 270

Ala?Val?Leu?Glu?Met?Leu?Glu?Asp?Ile?Lys?Ser?Asn?His?Gly?Gly?Asp

275 280 285

Ala?Thr?Glu?Phe?Met?Asn?Lys?Val?Lys?Asn?Lys?Glu?Asp?Gly?Val?Arg

290 295 300

Leu?Met?Gly?Phe?Gly?His?Arg?Val?Tyr?Lys?Asn?Tyr?Asp?Pro?Arg?Ala

305 310 315 320

Ala?Ile?Val?Lys?Glu?Thr?Ala?His?Glu?Ile?Leu?Glu?His?Leu?Gly?Gly

325 330 335

Asp?Asp?Leu?Leu?Asp?Leu?Ala?Ile?Lys?Leu?Glu?Glu?Ile?Ala?Leu?Ala

340 345 350

Asp?Asp?Tyr?Phe?Ile?Ser?Arg?Lys?Leu?Tyr?Pro?Asn?Val?Asp?Phe?Tyr

355 360 365

Thr?Gly?Leu?Ile?Tyr?Arg?Ala?Met?Gly?Phe?Pro?Thr?Asp?Phe?Phe?Thr

370 375 380

Val?Leu?Phe?Ala?Ile?Gly?Arg?Leu?Pro?Gly?Trp?Ile?Ala?His?Tyr?Arg

385 390 395 400

Glu?Gln?Leu?Gly?Ala?Ala?Gly?Asn?Lys?Ile?Asn?Arg?Pro?Arg?Gln?Val

405 410 415

Tyr?Thr?Gly?Asn?Glu?Ser?Arg?Lys?Leu?Val?Pro?Arg?Glu?Glu?Arg

420 425 430

<210>547

<211>942

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(919)

<223>RXA02621

<400>547

atgtacctga?ctggtgcgcg?acacttcgct?cactaaagtt?tttaaagatt?tcgcttgaag?60

gcagaccata?aggtctgcct?tttcgcgtat?taatgagtac?atg?tct?gaa?ctt?att 115

Met?Ser?Glu?Leu?Ile

1 5

tgt?gga?cca?gct?att?ctc?ttc?gca?cca?gct?gga?cgt?gct?gag?atc?att 163

Cys?Gly?Pro?Ala?Ile?Leu?Phe?Ala?Pro?Ala?Gly?Arg?Ala?Glu?Ile?Ile

10 15 20

cca?aaa?gca?gca?tcg?aag?gcc?gat?atg?gtc?atc?att?gat?ttg?gaa?gat 211

Pro?Lys?Ala?Ala?Ser?Lys?Ala?Asp?Met?Val?Ile?Ile?Asp?Leu?Glu?Asp

25 30 35

ggg?gca?ggg?gag?gta?gac?cgt?gag?gtc?gcc?tac?agg?aac?att?aga?gaa 259

Gly?Ala?Gly?Glu?Val?Asp?Arg?Glu?Val?Ala?Tyr?Arg?Asn?Ile?Arg?Glu

40 45 50

tcg?ggg?ttg?gat?cct?aaa?cga?acc?att?gtg?aga?acc?gta?ggg?ccg?agc 307

Ser?Gly?Leu?Asp?Pro?Lys?Arg?Thr?Ile?Val?Arg?Thr?Val?Gly?Pro?Ser

55 60 65

gat?cca?cac?ttt?ttg?gct?gac?gtg?gag?atg?gtg?aag?tcc?acg?gat?ttc 355

Asp?Pro?His?Phe?Leu?Ala?Asp?Val?Glu?Met?Val?Lys?Ser?Thr?Asp?Phe

70 75 80 85

aca?ctt?gtt?atg?gtt?cct?aaa?ctt?ctt?ggc?agc?gtg?cct?gag?gaa?tta 403

Thr?Leu?Val?Met?Val?Pro?Lys?Leu?Leu?Gly?Ser?Val?Pro?Glu?Glu?Leu

90 95 100

gat?ggc?ctc?aac?att?atc?gcc?atg?att?gaa?acc?cct?cag?gct?gca?acc 451

Asp?Gly?Leu?Asn?Ile?Ile?Ala?Met?Ile?Glu?Thr?Pro?Gln?Ala?Ala?Thr

105 110 115

agc?att?cct?cag?att?gct?gcg?gac?cct?aaa?gtc?gtt?gga?atg?ttc?tgg 499

Ser?Ile?Pro?Gln?Ile?Ala?Ala?Asp?Pro?Lys?Val?Val?Gly?Met?Phe?Trp

120 125 130

ggc?gcg?gag?gat?ctc?aca?cac?ctc?ttg?gga?ggc?act?cat?tct?agg?ttc 547

Gly?Ala?Glu?Asp?Leu?Thr?His?Leu?Leu?Gly?Gly?Thr?His?Ser?Arg?Phe

135 140 145

ttg?ggt?gat?gag?tcc?aat?gaa?ggc?tcc?tac?cga?gac?acc?atg?agg?ctt 595

Leu?Gly?Asp?Glu?Ser?Asn?Glu?Gly?Ser?Tyr?Arg?Asp?Thr?Met?Arg?Leu

150 155 160 165

aca?cgc?gcc?ctg?atg?cac?ctc?cac?gcg?gcg?gcg?aat?ggg?aag?ttc?acc 643

Thr?Arg?Ala?Leu?Met?His?Leu?His?Ala?Ala?Ala?Asn?Gly?Lys?Phe?Thr

170 175 180

att?gat?gcc?atc?cat?gcg?gat?ttc?cac?gat?gaa?gag?ggc?ctc?tat?tta 691

Ile?Asp?Ala?Ile?His?Ala?Asp?Phe?His?Asp?Glu?Glu?Gly?Leu?Tyr?Leu

185 190 195

gaa?gcg?gtc?gat?gct?gcg?cgg?act?ggt?ttc?gct?ggc?acc?gca?tgc?att 739

Glu?Ala?Val?Asp?Ala?Ala?Arg?Thr?Gly?Phe?Ala?Gly?Thr?Ala?Cys?Ile

200 205 210

cac?ccc?aag?cag?atc?gag?att?gtt?cgg?aga?gcc?tat?cgg?cca?gag?gct 787

His?Pro?Lys?Gln?Ile?Glu?Ile?Val?Arg?Arg?Ala?Tyr?Arg?Pro?Glu?Ala

215 220 225

aac?cag?ttg?gag?tgg?gcg?aag?aaa?gtg?gtg?gag?gaa?gca?gaa?aac?cat 835

Asn?Gln?Leu?Glu?Trp?Ala?Lys?Lys?Val?Val?Glu?Glu?Ala?Glu?Asn?His

230 235 240 245

cca?ggt?gcg?ttc?aaa?ctg?gat?ggt?cag?atg?att?gat?gct?ccg?ttg?att 883

Pro?Gly?Ala?Phe?Lys?Leu?Asp?Gly?Gln?Met?Ile?Asp?Ala?Pro?Leu?Ile

250 255 260

tcg?cag?gcg?cgg?atg?gtt?att?tcg?cgt?cag?cct?gct?tgattagttc 929

Ser?Gln?Ala?Arg?Met?Val?Ile?Ser?Arg?Gln?Pro?Ala

265 270

aagcgttttt?tcg 942

<210>548

<211>273

<212>PRT

＜213〉Corynebacterium glutamicum

<400>548

Met?Ser?Glu?Leu?Ile?Cys?Gly?Pro?Ala?Ile?Leu?Phe?Ala?Pro?Ala?Gly

1 5 10 15

Arg?Ala?Glu?Ile?Ile?Pro?Lys?Ala?Ala?Ser?Lys?Ala?Asp?Met?Val?Ile

20 25 30

Ile?Asp?Leu?Glu?Asp?Gly?Ala?Gly?Glu?Val?Asp?Arg?Glu?Val?Ala?Tyr

35 40 45

Arg?Asn?Ile?Arg?Glu?Ser?Gly?Leu?Asp?Pro?Lys?Arg?Thr?Ile?Val?Arg

50 55 60

Thr?Val?Gly?Pro?Ser?Asp?Pro?His?Phe?Leu?Ala?Asp?Val?Glu?Met?Val

65 70 75 80

Lys?Ser?Thr?Asp?Phe?Thr?Leu?Val?Met?Val?Pro?Lys?Leu?Leu?Gly?Ser

85 90 95

Val?Pro?Glu?Glu?Leu?Asp?Gly?Leu?Asn?Ile?Ile?Ala?Met?Ile?Glu?Thr

100 105 110

Pro?Gln?Ala?Ala?Thr?Ser?Ile?Pro?Gln?Ile?Ala?Ala?Asp?Pro?Lys?Val

115 120 125

Val?Gly?Met?Phe?Trp?Gly?Ala?Glu?Asp?Leu?Thr?His?Leu?Leu?Gly?Gly

130 135 140

Thr?His?Ser?Arg?Phe?Leu?Gly?Asp?Glu?Ser?Asn?Glu?Gly?Ser?Tyr?Arg

145 150 155 160

Asp?Thr?Met?Arg?Leu?Thr?Arg?Ala?Leu?Met?His?Leu?His?Ala?Ala?Ala

165 170 175

Asn?Gly?Lys?Phe?Thr?Ile?Asp?Ala?Ile?His?Ala?Asp?Phe?His?Asp?Glu

180 185 190

Glu?Gly?Leu?Tyr?Leu?Glu?Ala?Val?Asp?Ala?Ala?Arg?Thr?Gly?Phe?Ala

195 200 205

Gly?Thr?Ala?Cys?Ile?His?Pro?Lys?Gln?Ile?Glu?Ile?Val?Arg?Arg?Ala

210 215 220

Tyr?Arg?Pro?Glu?Ala?Asn?Gln?Leu?Glu?Trp?Ala?Lys?Lys?Val?Val?Glu

225 230 235 240

Glu?Ala?Glu?Asn?His?Pro?Gly?Ala?Phe?Lys?Leu?Asp?Gly?Gln?Met?Ile

245 250 255

Asp?Ala?Pro?Leu?Ile?Ser?Gln?Ala?Arg?Met?Val?Ile?Ser?Arg?Gln?Pro

260 265 270

Ala

<210>549

<211>2337

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(2314)

<223>RXN00519

<400>549

tttccatgcg?gggctgaaac?tgccaccata?ggcgccagca?attagtagaa?cactgtattc?60

taggtagctg?aacaaaagag?cccatcaacc?aaggagactc?atg?gct?aag?atc?atc 115

Met?Ala?Lys?Ile?Ile

1 5

tgg?acc?cgc?acc?gac?gaa?gca?ccg?ctg?ctc?gcg?acc?tac?tcg?ctg?aag 163

Trp?Thr?Arg?Thr?Asp?Glu?Ala?Pro?Leu?Leu?Ala?Thr?Tyr?Ser?Leu?Lys

10 15 20

ccg?gtc?gtc?gag?gca?ttt?gct?gct?acc?gcg?ggc?att?gag?gtc?gag?acc 211

Pro?Val?Val?Glu?Ala?Phe?Ala?Ala?Thr?Ala?Gly?Ile?Glu?Val?Glu?Thr

25 30 35

cgg?gac?att?tca?ctc?gct?gga?cgc?atc?ctc?gcc?cag?ttc?cca?gag?cgc 259

Arg?Asp?Ile?Ser?Leu?Ala?Gly?Arg?Ile?Leu?Ala?Gln?Phe?Pro?Glu?Arg

40 45 50

ctc?acc?gaa?gat?cag?aag?gta?ggc?aac?gca?ctc?gca?gaa?ctc?ggc?gag 307

Leu?Thr?Glu?Asp?Gln?Lys?Val?Gly?Asn?Ala?Leu?Ala?Glu?Leu?Gly?Glu

55 60 65

ctt?gct?aag?act?cct?gaa?gca?aac?atc?att?aag?ctt?cca?aac?atc?tcc 355

Leu?Ala?Lys?Thr?Pro?Glu?Ala?Asn?Ile?Ile?Lys?Leu?Pro?Asn?Ile?Ser

70 75 80 85

gct?tct?gtt?cca?cag?ctc?aag?gct?gct?att?aag?gaa?ctg?cag?gac?cag 403

Ala?Ser?Val?Pro?Gln?Leu?Lys?Ala?Ala?Ile?Lys?Glu?Leu?Gln?Asp?Gln

90 95 100

ggc?tac?gac?atc?cca?gaa?ctg?cct?gat?aac?gcc?acc?acc?gac?gag?gaa 451

Gly?Tyr?Asp?Ile?Pro?Glu?Leu?Pro?Asp?Asn?Ala?Thr?Thr?Asp?Glu?Glu

105 110 115

aaa?gac?atc?ctc?gca?cgc?tac?aac?gct?gtt?aag?ggt?tcc?gct?gtg?aac 499

Lys?Asp?Ile?Leu?Ala?Arg?Tyr?Asn?Ala?Val?Lys?Gly?Ser?Ala?Val?Asn

120 125 130

cca?gtg?ctg?cgt?gaa?ggc?aac?tct?gac?cgc?cgc?gca?cca?atc?gct?gtc 547

Pro?Val?Leu?Arg?Glu?Gly?Asn?Ser?Asp?Arg?Arg?Ala?Pro?Ile?Ala?Val

135 140 145

aag?aac?ttt?gtt?aag?aag?ttc?cca?cac?cgc?atg?ggc?gag?tgg?tct?gca 595

Lys?Asn?Phe?Val?Lys?Lys?Phe?Pro?His?Arg?Met?Gly?Glu?Trp?Ser?Ala

150 155 160 165

gat?tcc?aag?acc?aac?gtt?gca?acc?atg?gat?gca?aac?gac?ttc?cgc?cac 643

Asp?Ser?Lys?Thr?Asn?Val?Ala?Thr?Met?Asp?Ala?Asn?Asp?Phe?Arg?His

170 175 180

aac?gag?aag?tcc?atc?atc?ctc?gac?gct?gct?gat?gaa?gtt?cag?atc?aag 691

Asn?Glu?Lys?Ser?Ile?Ile?Leu?Asp?Ala?Ala?Asp?Glu?Val?Gln?Ile?Lys

185 190 195

cac?atc?gca?gct?gac?ggc?acc?gag?acc?atc?ctc?aag?gac?agc?ctc?aag 739

His?Ile?Ala?Ala?Asp?Gly?Thr?Glu?Thr?Ile?Leu?Lys?Asp?Ser?Leu?Lys

200 205 210

ctt?ctt?gaa?ggc?gaa?gtt?cta?gac?gga?acc?gtt?ctg?tcc?gca?aag?gca 787

Leu?Leu?Glu?Gly?Glu?Val?Leu?Asp?Gly?Thr?Val?Leu?Ser?Ala?Lys?Ala

215 220 225

ctg?gac?gca?ttc?ctt?ctc?gag?cag?gtc?gct?cgc?gca?aag?gca?gaa?ggt 835

Leu?Asp?Ala?Phe?Leu?Leu?Glu?Gln?Val?Ala?Arg?Ala?Lys?Ala?Glu?Gly

230 235 240 245

atc?ctc?ttc?tcc?gca?cac?ctg?aag?gcc?acc?atg?atg?aag?gtc?tcc?gac 883

Ile?Leu?Phe?Ser?Ala?His?Leu?Lys?Ala?Thr?Met?Met?Lys?Val?Ser?Asp

250 255 260

cca?atc?atc?ttc?ggc?cac?gtt?gtg?cgc?gct?tac?ttc?gca?gac?gtt?ttc 931

Pro?Ile?Ile?Phe?Gly?His?Val?Val?Arg?Ala?Tyr?Phe?Ala?Asp?Val?Phe

265 270 275

gca?cag?tac?ggt?gag?cag?ctg?ctc?gca?gct?ggc?ctc?aac?ggc?gaa?aac 979

Ala?Gln?Tyr?Gly?Glu?Gln?Leu?Leu?Ala?Ala?Gly?Leu?Asn?Gly?Glu?Asn

280 285 290

ggc?ctc?gct?gca?atc?ctc?tcc?ggc?ttg?gag?tcc?ctg?gac?aac?ggc?gaa 1027

Gly?Leu?Ala?Ala?Ile?Leu?Ser?Gly?Leu?Glu?Ser?Leu?Asp?Asn?Gly?Glu

295 300 305

gaa?atc?aag?gct?gca?ttc?gag?aag?ggc?ttg?gaa?gac?ggc?cca?gac?ctg 1075

Glu?Ile?Lys?Ala?Ala?Phe?Glu?Lys?Gly?Leu?Glu?Asp?Gly?Pro?Asp?Leu

310 315 320 325

gcc?atg?gtt?aac?tcc?gct?cgc?ggc?atc?acc?aac?ctg?cat?gtc?cct?tcc 1123

Ala?Met?Val?Asn?Ser?Ala?Arg?Gly?Ile?Thr?Asn?Leu?His?Val?Pro?Ser

330 335 340

gat?gtc?atc?gtg?gac?gct?tcc?atg?cca?gca?atg?att?cgt?acc?tcc?ggc 1171

Asp?Val?Ile?Val?Asp?Ala?Ser?Met?Pro?Ala?Met?Ile?Arg?Thr?Ser?Gly

345 350 355

cac?atg?tgg?aac?aaa?gac?gac?cag?gag?cag?gac?acc?ctg?gca?atc?atc 1219

His?Met?Trp?Asn?Lys?Asp?Asp?Gln?Glu?Gln?Asp?Thr?Leu?Ala?Ile?Ile

360 365 370

cca?gac?tcc?tcc?tac?gct?ggc?gtc?tac?cag?acc?gtt?atc?gaa?gac?tgc 1267

Pro?Asp?Ser?Ser?Tyr?Ala?Gly?Val?Tyr?Gln?Thr?Val?Ile?Glu?Asp?Cys

375 380 385

cgc?aag?aac?ggc?gca?ttc?gat?cca?acc?acc?atg?ggt?acc?gtc?cct?aac 1315

Arg?Lys?Asn?Gly?Ala?Phe?Asp?Pro?Thr?Thr?Met?Gly?Thr?Val?Pro?Asn

390 395 400 405

gtt?ggt?ctg?atg?gct?cag?aag?gct?gaa?gag?tac?ggc?tcc?cat?gac?aag 1363

Val?Gly?Leu?Met?Ala?Gln?Lys?Ala?Glu?Glu?Tyr?Gly?Ser?His?Asp?Lys

410 415 420

acc?ttc?cgc?atc?gaa?gca?gac?ggt?gtg?gtt?cag?gtt?gtt?tcc?tcc?aac 1411

Thr?Phe?Arg?Ile?Glu?Ala?Asp?Gly?Val?Val?Gln?Val?Val?Ser?Ser?Asn

425 430 435

ggc?gac?gtt?ctc?atc?gag?cac?gac?gtt?gag?gca?aat?gac?atc?tgg?cgt 1459

Gly?Asp?Val?Leu?Ile?Glu?His?Asp?Val?Glu?Ala?Asn?Asp?Ile?Trp?Arg

440 445 450

gca?tgc?cag?gtc?aag?gat?gcc?cca?atc?cag?gat?tgg?gta?aag?ctt?gct 1507

Ala?Cys?Gln?Val?Lys?Asp?Ala?Pro?Ile?Gln?Asp?Trp?Val?Lys?Leu?Ala

455 460 465

gtc?acc?cgc?tcc?cgt?ctc?tcc?gga?atg?cct?gca?gtg?ttc?tgg?ttg?gat 1555

Val?Thr?Arg?Ser?Arg?Leu?Ser?Gly?Met?Pro?Ala?Val?Phe?Trp?Leu?Asp

470 475 480 485

cca?gag?cgc?gca?cac?gac?cgc?aac?ctg?gct?tcc?ctc?gtt?gag?aag?tac 1603

Pro?Glu?Arg?Ala?His?Asp?Arg?Asn?Leu?Ala?Ser?Leu?Val?Glu?Lys?Tyr

490 495 500

ctg?gct?gac?cac?gac?acc?gag?ggc?ctg?gac?atc?cag?atc?ctc?tcc?cct 1651

Leu?Ala?Asp?His?Asp?Thr?Glu?Gly?Leu?Asp?Ile?Gln?Ile?Leu?Ser?Pro

505 510 515

gtt?gag?gca?acc?cag?ctc?tcc?atc?gac?cgc?atc?cgc?cgt?ggc?gag?gac 1699

Val?Glu?Ala?Thr?Gln?Leu?Ser?Ile?Asp?Arg?Ile?Arg?Arg?Gly?Glu?Asp

520 525 530

acc?atc?tct?gtc?acc?ggt?aac?gtt?ctg?cgt?gac?tac?aac?acc?gac?ctc 1747

Thr?Ile?Ser?Val?Thr?Gly?Asn?Val?Leu?Arg?Asp?Tyr?Asn?Thr?Asp?Leu

535 540 545

ttc?cca?atc?ctg?gag?ctg?ggc?acc?tct?gca?aag?atg?ctg?tct?gtc?gtt 1795

Phe?Pro?Ile?Leu?Glu?Leu?Gly?Thr?Ser?Ala?Lys?Met?Leu?Ser?Val?Val

550 555 560 565

cct?ttg?atg?gct?ggc?ggc?gga?ctg?ttc?gag?acc?ggt?gct?ggt?gga?tct 1843

Pro?Leu?Met?Ala?Gly?Gly?Gly?Leu?Phe?Glu?Thr?Gly?Ala?Gly?Gly?Ser

570 575 580

gct?cct?aag?cac?gtc?cag?cag?gtt?cag?gaa?gaa?aac?cac?ctg?cgt?tgg 1891

Ala?Pro?Lys?His?Val?Gln?Gln?Val?Gln?Glu?Glu?Asn?His?Leu?Arg?Trp

585 590 595

gat?tcc?ctc?ggt?gag?ttc?ctc?gca?ctg?gct?gag?tcc?ttc?cgc?cac?gag 1939

Asp?Ser?Leu?Gly?Glu?Phe?Leu?Ala?Leu?Ala?Glu?Ser?Phe?Arg?His?Glu

600 605 610

ctc?aac?aac?aac?ggc?aac?acc?aag?gcc?ggc?gtt?ctg?gct?gac?gct?ctg 1987

Leu?Asn?Asn?Asn?Gly?Asn?Thr?Lys?Ala?Gly?Val?Leu?Ala?Asp?Ala?Leu

615 620 625

gac?aag?gca?act?gag?aag?ctg?ctg?aac?gaa?gag?aag?tcc?cca?tcc?cgc 2035

Asp?Lys?Ala?Thr?Glu?Lys?Leu?Leu?Asn?Glu?Glu?Lys?Ser?Pro?Ser?Arg

630 635 640 645

aag?gtt?ggc?gag?atc?gac?aac?cgt?ggc?tcc?cac?ttc?tgg?ctg?acc?aag 2083

Lys?Val?Gly?Glu?Ile?Asp?Asn?Arg?Gly?Ser?His?Phe?Trp?Leu?Thr?Lys

650 655 660

ttc?tgg?gct?gac?gag?ctc?gct?gct?cag?acc?gag?gac?gca?gat?ctg?gct 2131

Phe?Trp?Ala?Asp?Glu?Leu?Ala?Ala?Gln?Thr?Glu?Asp?Ala?Asp?Leu?Ala

665 670 675

gct?acc?ttc?gca?cca?gtc?gca?gaa?gca?ctg?aac?aca?ggc?gct?gca?gac 2179

Ala?Thr?Phe?Ala?Pro?Val?Ala?Glu?Ala?Leu?Asn?Thr?Gly?Ala?Ala?Asp

680 685 690

atc?gat?gct?gca?ctg?ctc?gca?gtt?cag?ggt?gga?gca?act?gac?ctt?ggt 2227

Ile?Asp?Ala?Ala?Leu?Leu?Ala?Val?Gln?Gly?Gly?Ala?Thr?Asp?Leu?Gly

695 700 705

ggc?tac?tac?tcc?cct?aac?gag?gag?aag?ctc?acc?aac?atc?atg?cgc?cca 2275

Gly?Tyr?Tyr?Ser?Pro?Asn?Glu?Glu?Lys?Leu?Thr?Asn?Ile?Met?Arg?Pro

710 715 720 725

gtc?gca?cag?ttc?aac?gag?atc?gtt?gac?gca?ctg?aag?aag?taaagtctct 2324

Val?Ala?Gln?Phe?Asn?Glu?Ile?Val?Asp?Ala?Leu?Lys?Lys

730 735

tcacaaaaag?cgc 2337

<210>550

<211>738

<212>PRT

＜213〉Corynebacterium glutamicum

<400>550

Met?Ala?Lys?Ile?Ile?Trp?Thr?Arg?Thr?Asp?Glu?Ala?Pro?Leu?Leu?Ala

1 5 10 15

Thr?Tyr?Ser?Leu?Lys?Pro?Val?Val?Glu?Ala?Phe?Ala?Ala?Thr?Ala?Gly

20 25 30

Ile?Glu?Val?Glu?Thr?Arg?Asp?Ile?Ser?Leu?Ala?Gly?Arg?Ile?Leu?Ala

35 40 45

Gln?Phe?Pro?Glu?Arg?Leu?Thr?Glu?Asp?Gln?Lys?Val?Gly?Asn?Ala?Leu

50 55 60

Ala?Glu?Leu?Gly?Glu?Leu?Ala?Lys?Thr?Pro?Glu?Ala?Asn?Ile?Ile?Lys

65 70 75 80

Leu?Pro?Asn?Ile?Ser?Ala?Ser?Val?Pro?Gln?Leu?Lys?Ala?Ala?Ile?Lys

85 90 95

Glu?Leu?Gln?Asp?Gln?Gly?Tyr?Asp?Ile?Pro?Glu?Leu?Pro?Asp?Asn?Ala

100 105 110

Thr?Thr?Asp?Glu?Glu?Lys?Asp?Ile?Leu?Ala?Arg?Tyr?Asn?Ala?Val?Lys

115 120 125

Gly?Ser?Ala?Val?Asn?Pro?Val?Leu?Arg?Glu?Gly?Asn?Ser?Asp?Arg?Arg

130 135 140

Ala?Pro?Ile?Ala?Val?Lys?Asn?Phe?Val?Lys?Lys?Phe?Pro?His?Arg?Met

145 150 155 160

Gly?Glu?Trp?Ser?Ala?Asp?Ser?Lys?Thr?Asn?Val?Ala?Thr?Met?Asp?Ala

165 170 175

Asn?Asp?Phe?Arg?His?Asn?Glu?Lys?Ser?Ile?Ile?Leu?Asp?Ala?Ala?Asp

180 185 190

Glu?Val?Gln?Ile?Lys?His?Ile?Ala?Ala?Asp?Gly?Thr?Glu?Thr?Ile?Leu

195 200 205

Lys?Asp?Ser?Leu?Lys?Leu?Leu?Glu?Gly?Glu?Val?Leu?Asp?Gly?Thr?Val

210 215 220

Leu?Ser?Ala?Lys?Ala?Leu?Asp?Ala?Phe?Leu?Leu?Glu?Gln?Val?Ala?Arg

225 230 235 240

Ala?Lys?Ala?Glu?Gly?Ile?Leu?Phe?Ser?Ala?His?Leu?Lys?Ala?Thr?Met

245 250 255

Met?Lys?Val?Ser?Asp?Pro?Ile?Ile?Phe?Gly?His?Val?Val?Arg?Ala?Tyr

260 265 270

Phe?Ala?Asp?Val?Phe?Ala?Gln?Tyr?Gly?Glu?Gln?Leu?Leu?Ala?Ala?Gly

275 280 285

Leu?Asn?Gly?Glu?Asn?Gly?Leu?Ala?Ala?Ile?Leu?Ser?Gly?Leu?Glu?Ser

290 295 300

Leu?Asp?Asn?Gly?Glu?Glu?Ile?Lys?Ala?Ala?Phe?Glu?Lys?Gly?Leu?Glu

305 310 315 320

Asp?Gly?Pro?Asp?Leu?Ala?Met?Val?Asn?Ser?Ala?Arg?Gly?Ile?Thr?Asn

325 330 335

Leu?His?Val?Pro?Ser?Asp?Val?Ile?Val?Asp?Ala?Ser?Met?Pro?Ala?Met

340 345 350

Ile?Arg?Thr?Ser?Gly?His?Met?Trp?Asn?Lys?Asp?Asp?Gln?Glu?Gln?Asp

355 360 365

Thr?Leu?Ala?Ile?Ile?Pro?Asp?Ser?Ser?Tyr?Ala?Gly?Val?Tyr?Gln?Thr

370 375 380

Val?Ile?Glu?Asp?Cys?Arg?Lys?Asn?Gly?Ala?Phe?Asp?Pro?Thr?Thr?Met

385 390 395 400

Gly?Thr?Val?Pro?Asn?Val?Gly?Leu?Met?Ala?Gln?Lys?Ala?Glu?Glu?Tyr

405 410 415

Gly?Ser?His?Asp?Lys?Thr?Phe?Arg?Ile?Glu?Ala?Asp?Gly?Val?Val?Gln

420 425 430

Val?Val?Ser?Ser?Asn?Gly?Asp?Val?Leu?Ile?Glu?His?Asp?Val?Glu?Ala

435 440 445

Asn?Asp?Ile?Trp?Arg?Ala?Cys?Gln?Val?Lys?Asp?Ala?Pro?Ile?Gln?Asp

450 455 460

Trp?Val?Lys?Leu?Ala?Val?Thr?Arg?Ser?Arg?Leu?Ser?Gly?Met?Pro?Ala

465 470 475 480

Val?Phe?Trp?Leu?Asp?Pro?Glu?Arg?Ala?His?Asp?Arg?Asn?Leu?Ala?Ser

485 490 495

Leu?Val?Glu?Lys?Tyr?Leu?Ala?Asp?His?Asp?Thr?Glu?Gly?Leu?Asp?Ile

500 505 510

Gln?Ile?Leu?Ser?Pro?Val?Glu?Ala?Thr?Gln?Leu?Ser?Ile?Asp?Arg?Ile

515 520 525

Arg?Arg?Gly?Glu?Asp?Thr?Ile?Ser?Val?Thr?Gly?Asn?Val?Leu?Arg?Asp

530 535 540

Tyr?Asn?Thr?Asp?Leu?Phe?Pro?Ile?Leu?Glu?Leu?Gly?Thr?Ser?Ala?Lys

545 550 555 560

Met?Leu?Ser?Val?Val?Pro?Leu?Met?Ala?Gly?Gly?Gly?Leu?Phe?Glu?Thr

565 570 575

Gly?Ala?Gly?Gly?Ser?Ala?Pro?Lys?His?Val?Gln?Gln?Val?Gln?Glu?Glu

580 585 590

Asn?His?Leu?Arg?Trp?Asp?Ser?Leu?Gly?Glu?Phe?Leu?Ala?Leu?Ala?Glu

595 600 605

Ser?Phe?Arg?His?Glu?Leu?Asn?Asn?Asn?Gly?Asn?Thr?Lys?Ala?Gly?Val

610 615 620

Leu?Ala?Asp?Ala?Leu?Asp?Lys?Ala?Thr?Glu?Lys?Leu?Leu?Asn?Glu?Glu

625 630 635 640

Lys?Ser?Pro?Ser?Arg?Lys?Val?Gly?Glu?Ile?Asp?Asn?Arg?Gly?Ser?His

645 650 655

Phe?Trp?Leu?Thr?Lys?Phe?Trp?Ala?Asp?Glu?Leu?Ala?Ala?Gln?Thr?Glu

660 665 670

Asp?Ala?Asp?Leu?Ala?Ala?Thr?Phe?Ala?Pro?Val?Ala?Glu?Ala?Leu?Asn

675 680 685

Thr?Gly?Ala?Ala?Asp?Ile?Asp?Ala?Ala?Leu?Leu?Ala?Val?Gln?Gly?Gly

690 695 700

Ala?Thr?Asp?Leu?Gly?Gly?Tyr?Tyr?Ser?Pro?Asn?Glu?Glu?Lys?Leu?Thr

705 710 715 720

Asn?Ile?Met?Arg?Pro?Val?Ala?Gln?Phe?Asn?Glu?Ile?Val?Asp?Ala?Leu

725 730 735

Lys?Lys

<210>551

<211>1059

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(1059)

<223>FRXA00521

<400>551

ctc?gac?gct?gct?gat?gaa?gtt?cag?atc?aag?cac?atc?gca?gct?gac?ggc 48

Leu?Asp?Ala?Ala?Asp?Glu?Val?Gln?Ile?Lys?His?Ile?Ala?Ala?Asp?Gly

1 5 10 15

acc?gag?acc?atc?ctc?aag?gac?agc?ctc?aag?ctt?ctt?gaa?ggc?gaa?gtt 96

Thr?Glu?Thr?Ile?Leu?Lys?Asp?Ser?Leu?Lys?Leu?Leu?Glu?Gly?Glu?Val

20 25 30

cta?gac?gga?acc?gtt?ctg?tcc?gca?aag?gca?ctg?gac?gca?ttc?ctt?ctc 144

Leu?Asp?Gly?Thr?Val?Leu?Ser?Ala?Lys?Ala?Leu?Asp?Ala?Phe?Leu?Leu

35 40 45

gag?cag?gtc?gct?cgc?gca?aag?gca?gaa?ggt?atc?ctc?ttc?tcc?gca?cac 192

Glu?Gln?Val?Ala?Arg?Ala?Lys?Ala?Glu?Gly?Ile?Leu?Phe?Ser?Ala?His

50 55 60

ctg?aag?gcc?acc?atg?atg?aag?gtc?tcc?gac?cca?atc?atc?ttc?ggc?cac 240

Leu?Lys?Ala?Thr?Met?Met?Lys?Val?Ser?Asp?Pro?Ile?Ile?Phe?Gly?His

65 70 75 80

gtt?gtg?cgc?gct?tac?ttc?gca?gac?gtt?ttc?gca?cag?tac?ggt?gag?cag 288

Val?Val?Arg?Ala?Tyr?Phe?Ala?Asp?Val?Phe?Ala?Gln?Tyr?Gly?Glu?Gln

85 90 95

ctg?ctc?gca?gct?ggc?ctc?aac?ggc?gaa?aac?ggc?ctc?gct?gca?atc?ctc 336

Leu?Leu?Ala?Ala?Gly?Leu?Asn?Gly?Glu?Asn?Gly?Leu?Ala?Ala?Ile?Leu

100 105 110

tcc?ggc?ttg?gag?tcc?ctg?gac?aac?ggc?gaa?gaa?atc?aag?gct?gca?ttc 384

Ser?Gly?Leu?Glu?Ser?Leu?Asp?Asn?Gly?Glu?Glu?Ile?Lys?Ala?Ala?Phe

115 120 125

gag?aag?ggc?ttg?gaa?gac?ggc?cca?gac?ctg?gcc?atg?gtt?aac?tcc?gct 432

Glu?Lys?Gly?Leu?Glu?Asp?Gly?Pro?Asp?Leu?Ala?Met?Val?Asn?Ser?Ala

130 135 140

cgc?ggc?atc?acc?aac?ctg?cat?gtc?cct?tcc?gat?gtc?atc?gtg?gac?gct 480

Arg?Gly?Ile?Thr?Asn?Leu?His?Val?Pro?Ser?Asp?Val?Ile?Val?Asp?Ala

145 150 155 160

tcc?atg?cca?gca?atg?att?cgt?acc?tcc?ggc?cac?atg?tgg?aac?aaa?gac 528

Ser?Met?Pro?Ala?Met?Ile?Arg?Thr?Ser?Gly?His?Met?Trp?Asn?Lys?Asp

165 170 175

gac?cag?gag?cag?gac?acc?ctg?gca?atc?atc?cca?gac?tcc?tcc?tac?gct 576

Asp?Gln?Glu?Gln?Asp?Thr?Leu?Ala?Ile?Ile?Pro?Asp?Ser?Ser?Tyr?Ala

180 185 190

ggc?gtc?tac?cag?acc?gtt?atc?gaa?gac?tgc?cgc?aag?aac?ggc?gca?ttc 624

Gly?Val?Tyr?Gln?Thr?Val?Ile?Glu?Asp?Cys?Arg?Lys?Asn?Gly?Ala?Phe

195 200 205

gat?cea?acc?acc?atg?ggt?acc?gtc?cct?aac?gtt?ggt?ctg?atg?gct?cag 672

Asp?Pro?Thr?Thr?Met?Gly?Thr?Val?Pro?Asn?Val?Gly?Leu?Met?Ala?Gln

210 215 220

aag?gct?gaa?gag?tac?ggc?tcc?cat?gac?aag?acc?ttc?cgc?atc?gaa?gca 720

Lys?Ala?Glu?Glu?Tyr?Gly?Ser?His?Asp?Lys?Thr?Phe?Arg?Ile?Glu?Ala

225 230 235 240

gac?ggt?gtg?gtt?cag?gtt?gtt?tcc?tcc?aac?ggc?gac?gtt?ctc?atc?gag 768

Asp?Gly?Val?Val?Gln?Val?Val?Ser?Ser?Asn?Gly?Asp?Val?Leu?Ile?Glu

245 250 255

cac?gac?gtt?gag?gca?aat?gac?atc?tgg?cgt?gca?tgc?cag?gtc?aag?gat 816

His?Asp?Val?Glu?Ala?Asn?Asp?Ile?Trp?Arg?Ala?Cys?Gln?Val?Lys?Asp

260 265 270

gcc?cca?atc?cag?gat?tgg?gta?aag?ctt?gct?gtc?acc?cgc?tcc?cgt?ctc 864

Ala?Pro?Ile?Gln?Asp?Trp?Val?Lys?Leu?Ala?Val?Thr?Arg?Ser?Arg?Leu

275 280 285

tcc?gga?atg?cct?gca?gtg?ttc?tgg?ttg?gat?cca?gag?cgc?gca?cac?gac 912

Ser?Gly?Met?Pro?Ala?Val?Phe?Trp?Leu?Asp?Pro?Glu?Arg?Ala?His?Asp

290 295 300

cgc?aac?ctg?gct?tcc?ctc?gtt?gag?aag?tac?ctg?gct?gac?cac?gac?acc 960

Arg?Asn?Leu?Ala?Ser?Leu?Val?Glu?Lys?Tyr?Leu?Ala?Asp?His?Asp?Thr

305 310 315 320

gag?ggc?ctg?gac?atc?cag?atc?ctc?tac?cct?gtt?gag?gca?acc?cag?ctc 1008

Glu?Gly?Leu?Asp?Ile?Gln?Ile?Leu?Tyr?Pro?Val?Glu?Ala?Thr?Gln?Leu

325 330 335

tcc?atc?gac?cgc?atc?cgc?cgt?ggc?gag?gac?acc?atc?tct?gtc?acc?ggt 1056

Ser?Ile?Asp?Arg?Ile?Arg?Arg?Gly?Glu?Asp?Thr?Ile?Ser?Val?Thr?Gly

340 345 350

aac 1059

Asn

<210>552

<211>353

<212>PRT

＜213〉Corynebacterium glutamicum

<400>?552

Leu?Asp?Ala?Ala?Asp?Glu?Val?Gln?Ile?Lys?His?Ile?Ala?Ala?Asp?Gly

1 5 10 15

Thr?Glu?Thr?Ile?Leu?Lys?Asp?Ser?Leu?Lys?Leu?Leu?Glu?Gly?Glu?Val

20 25 30

Leu?Asp?Gly?Thr?Val?Leu?Ser?Ala?Lys?Ala?Leu?Asp?Ala?Phe?Leu?Leu

35 40 45

Glu?Gln?Val?Ala?Arg?Ala?Lys?Ala?Glu?Gly?Ile?Leu?Phe?Ser?Ala?His

50 55 60

Leu?Lys?Ala?Thr?Met?Met?Lys?Val?Ser?Asp?Pro?Ile?Ile?Phe?Gly?His

65 70 75 80

Val?Val?Arg?Ala?Tyr?Phe?Ala?Asp?Val?Phe?Ala?Gln?Tyr?Gly?Glu?Gln

85 90 95

Leu?Leu?Ala?Ala?Gly?Leu?Asn?Gly?Glu?Asn?Gly?Leu?Ala?Ala?Ile?Leu

100 105 110

Ser?Gly?Leu?Glu?Ser?Leu?Asp?Asn?Gly?Glu?Glu?Ile?Lys?Ala?Ala?Phe

115 120 125

Glu?Lys?Gly?Leu?Glu?Asp?Gly?Pro?Asp?Leu?Ala?Met?Val?Asn?Ser?Ala

130 135 140

Arg?Gly?Ile?Thr?Asn?Leu?His?Val?Pro?Ser?Asp?Val?Ile?Val?Asp?Ala

145 150 155 160

Ser?Met?Pro?Ala?Met?Ile?Arg?Thr?Ser?Gly?His?Met?Trp?Asn?Lys?Asp

165 170 175

Asp?Gln?Glu?Gln?Asp?Thr?Leu?Ala?Ile?Ile?Pro?Asp?Ser?Ser?Tyr?Ala

180 185 190

Gly?Val?Tyr?Gln?Thr?Val?Ile?Glu?Asp?Cys?Arg?Lys?Asn?Gly?Ala?Phe

195 200 205

Asp?Pro?Thr?Thr?Met?Gly?Thr?Val?Pro?Asn?Val?Gly?Leu?Met?Ala?Gln

210 215 220

Lys?Ala?Glu?Glu?Tyr?Gly?Ser?His?Asp?Lys?Thr?Phe?Arg?Ile?Glu?Ala

225 230 235 240

Asp?Gly?Val?Val?Gln?Val?Val?Ser?Ser?Asn?Gly?Asp?Val?Leu?Ile?Glu

245 250 255

His?Asp?Val?Glu?Ala?Asn?Asp?Ile?Trp?Arg?Ala?Cys?Gln?Val?Lys?Asp

260 265 270

Ala?Pro?Ile?Gln?Asp?Trp?Val?Lys?Leu?Ala?Val?Thr?Arg?Ser?Arg?Leu

275 280 285

Ser?Gly?Met?Pro?Ala?Val?Phe?Trp?Leu?Asp?Pro?Glu?Arg?Ala?His?Asp

290 295 300

Arg?Asn?Leu?Ala?Ser?Leu?Val?Glu?Lys?Tyr?Leu?Ala?Asp?His?Asp?Thr

305 310 315 320

Glu?Gly?Leu?Asp?Ile?Gln?Ile?Leu?Tyr?Pro?Val?Glu?Ala?Thr?Gln?Leu

325 330 335

Ser?Ile?Asp?Arg?Ile?Arg?Arg?Gly?Glu?Asp?Thr?Ile?Ser?Val?Thr?Gly

340 345 350

Asn

<210>553

<211>1694

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(1671)

<223>RXN02209

<400>553

acc?gag?tcc?acc?gtt?gtt?cct?tcc?atc?gct?ggc?cct?aag?cgc?cca?cag 48

Thr?Glu?Ser?Thr?Val?Val?Pro?Ser?Ile?Ala?Gly?Pro?Lys?Arg?Pro?Gln

1 5 10 15

gac?cgc?atc?ctt?ctc?tcc?gag?gca?aag?gag?cag?ttc?cgt?aag?gat?ctg 96

Asp?Arg?Ile?Leu?Leu?Ser?Glu?Ala?Lys?Glu?Gln?Phe?Arg?Lys?Asp?Leu

20 25 30

cca?acc?tac?acc?gac?gac?gct?gtt?tcc?gta?gac?acc?tcc?atc?cct?gca 144

Pro?Thr?Tyr?Thr?Asp?Asp?Ala?Val?Ser?Val?Asp?Thr?Ser?Ile?Pro?Ala

35 40 45

acc?cgc?atg?gtt?aac?gaa?ggt?ggc?gga?cag?cct?gaa?ggc?ggc?gtc?gaa 192

Thr?Arg?Met?Val?Asn?Glu?Gly?Gly?Gly?Gln?Pro?Glu?Gly?Gly?Val?Glu

50 55 60

gct?gac?aac?tac?aac?gct?tcc?tgg?gct?ggc?tcc?ggc?gag?tcc?ttg?gct 240

Ala?Asp?Asn?Tyr?Asn?Ala?Ser?Trp?Ala?Gly?Ser?Gly?Glu?Ser?Leu?Ala

65 70 75 80

act?ggc?gca?gaa?gga?cgt?cct?tcc?aag?cca?gtc?acc?gtt?gca?tcc?cca 288

Thr?Gly?Ala?Glu?Gly?Arg?Pro?Ser?Lys?Pro?Val?Thr?Val?Ala?Ser?Pro

85 90 95

cag?ggt?ggc?gag?tac?acc?atc?gac?cac?ggc?atg?gtt?gca?att?gca?tcc 336

Gln?Gly?Gly?Glu?Tyr?Thr?Ile?Asp?His?Gly?Met?Val?Ala?Ile?Ala?Ser

100 105 110

atc?acc?tct?tgc?acc?aac?acc?tct?aac?cca?tcc?gtg?atg?atc?ggc?gct 384

Ile?Thr?Ser?Cys?Thr?Asn?Thr?Ser?Asn?Pro?Ser?Val?Met?Ile?Gly?Ala

115 120 125

ggc?ctg?atc?gca?cgt?aag?gca?gca?gaa?aag?ggc?ctc?aag?tcc?aag?cct 432

Gly?Leu?Ile?Ala?Arg?Lys?Ala?Ala?Glu?Lys?Gly?Leu?Lys?Ser?Lys?Pro

130 135 140

tgg?gtt?aag?acc?atc?tgt?gca?cca?ggt?tcc?cag?gtt?gtc?gac?ggc?tac 480

Trp?Val?Lys?Thr?Ile?Cys?Ala?Pro?Gly?Ser?Gln?Val?Val?Asp?Gly?Tyr

145 150 155 160

tac?cag?cgc?gca?gac?ctc?tgg?aag?gac?ctt?gag?gcc?atg?ggc?ttc?tac 528

Tyr?Gln?Arg?Ala?Asp?Leu?Trp?Lys?Asp?Leu?Glu?Ala?Met?Gly?Phe?Tyr

165 170 175

ctc?tcc?ggc?ttc?ggc?tgc?acc?acc?tgt?att?ggt?aac?tcc?ggc?cca?ctg 576

Leu?Ser?Gly?Phe?Gly?Cys?Thr?Thr?Cys?Ile?Gly?Asn?Ser?Gly?Pro?Leu

180 185 190

cca?gag?gaa?atc?tcc?gct?gcg?atc?aac?gag?cac?gac?ctg?acc?gca?acc 624

Pro?Glu?Glu?Ile?Ser?Ala?Ala?Ile?Asn?Glu?His?Asp?Leu?Thr?Ala?Thr

195 200 205

gca?gtt?ttg?tcc?ggt?aac?cgt?aac?ttc?gag?gga?cgt?atc?tcc?cct?gac 672

Ala?Val?Leu?Ser?Gly?Asn?Arg?Asn?Phe?Glu?Gly?Arg?Ile?Ser?Pro?Asp

210 215 220

gtt?aag?atg?aac?tac?ctg?gca?tcc?cca?atc?atg?gtc?att?gct?tac?gca 720

Val?Lys?Met?Asn?Tyr?Leu?Ala?Ser?Pro?Ile?Met?Val?Ile?Ala?Tyr?Ala

225 230 235 240

atc?gct?ggc?acc?atg?gac?ttc?gac?ttc?gag?aac?gaa?gct?ctt?gga?cag 768

Ile?Ala?Gly?Thr?Met?Asp?Phe?Asp?Phe?Glu?Asn?Glu?Ala?Leu?Gly?Gln

245 250 255

gac?cag?gac?ggc?aac?gac?gtc?ttc?ctg?aag?gac?atc?tgg?cct?tcc?acc 816

Asp?Gln?Asp?Gly?Asn?Asp?Val?Phe?Leu?Lys?Asp?Ile?Trp?Pro?Ser?Thr

260 265 270

gag?gaa?atc?gaa?gac?acc?atc?cag?cag?gca?atc?tcc?cgt?gag?ctt?tac 864

Glu?Glu?Ile?Glu?Asp?Thr?Ile?Gln?Gln?Ala?Ile?Ser?Arg?Glu?Leu?Tyr

275 280 285

gaa?gct?gac?tac?gca?gat?gtc?ttc?aag?ggt?gac?aag?cag?tgg?cag?gaa 912

Glu?Ala?Asp?Tyr?Ala?Asp?Val?Phe?Lys?Gly?Asp?Lys?Gln?Trp?Gln?Glu

290 295 300

ctc?gat?gtt?cct?acc?ggt?gac?acc?ttc?gag?tgg?gac?gag?aac?tcc?acc 960

Leu?Asp?Val?Pro?Thr?Gly?Asp?Thr?Phe?Glu?Trp?Asp?Glu?Asn?Ser?Thr

305 310 315 320

tac?atc?cgc?aag?gca?cct?tac?ttc?gac?ggc?atg?cct?gtc?gag?cca?gtg 1008

Tyr?Ile?Arg?Lys?Ala?Pro?Tyr?Phe?Asp?Gly?Met?Pro?Val?Glu?Pro?Val

325 330 335

gca?gtc?acc?gac?atc?cag?ggc?gca?cgc?gtt?ctg?gct?aag?ctc?ggc?gac 1056

Ala?Val?Thr?Asp?Ile?Gln?Gly?Ala?Arg?Val?Leu?Ala?Lys?Leu?Gly?Asp

340 345 350

tct?gtc?acc?acc?gac?cac?atc?tcc?cct?gct?tcc?tcc?att?aag?cca?ggt 1104

Ser?Val?Thr?Thr?Asp?His?Ile?Ser?Pro?Ala?Ser?Ser?Ile?Lys?Pro?Gly

355 360 365

acc?cct?gca?gct?cag?tac?ttg?gat?gag?cac?ggt?gtg?gaa?cgc?cac?gac 1152

Thr?Pro?Ala?Ala?Gln?Tyr?Leu?Asp?Glu?His?Gly?Val?Glu?Arg?His?Asp

370 375 380

tac?aac?tcc?ctg?ggt?tcc?agg?cgt?ggt?aac?cac?gag?gtc?atg?atg?cgc 1200

Tyr?Asn?Ser?Leu?Gly?Ser?Arg?Arg?Gly?Asn?His?Glu?Val?Met?Met?Arg

385 390 395 400

ggc?acc?ttc?gcc?aac?atc?cgc?ctc?cag?aac?cag?ctg?gtt?gac?atc?gca 1248

Gly?Thr?Phe?Ala?Asn?Ile?Arg?Leu?Gln?Asn?Gln?Leu?Val?Asp?Ile?Ala

405 410 415

ggt?ggc?tac?acc?cgc?gac?ttc?acc?cag?gag?ggt?gct?cca?cag?gcg?ttc 1296

Gly?Gly?Tyr?Thr?Arg?Asp?Phe?Thr?Gln?Glu?Gly?Ala?Pro?Gln?Ala?Phe

420 425 430

atc?tac?gac?gct?tcc?gtc?aac?tac?aag?gct?gct?ggc?att?ccg?ctg?gtc 1344

Ile?Tyr?Asp?Ala?Ser?Val?Asn?Tyr?Lys?Ala?Ala?Gly?Ile?Pro?Leu?Val

435 440 445

gtc?ttg?ggc?ggc?aag?gag?tac?ggc?acc?ggt?tct?tcc?cgt?gac?tgg?gca 1392

Val?Leu?Gly?Gly?Lys?Glu?Tyr?Gly?Thr?Gly?Ser?Ser?Arg?Asp?Trp?Ala

450 455 460

gct?aag?ggc?act?aac?ctg?ctc?gga?att?cgc?gca?gtt?atc?acc?gag?tcc 1440

Ala?Lys?Gly?Thr?Asn?Leu?Leu?Gly?Ile?Arg?Ala?Val?Ile?Thr?Glu?Ser

465 470 475 480

ttc?gag?cgt?att?cac?cgc?tcc?aac?ctc?atc?ggt?atg?ggc?gtt?gtc?cca 1488

Phe?Glu?Arg?Ile?His?Arg?Ser?Asn?Leu?Ile?Gly?Met?Gly?Val?Val?Pro

485 490 495

ctg?cag?ttc?cct?gca?ggc?gaa?tcc?cac?gag?tcc?ctg?ggc?ctt?gac?ggc 1536

Leu?Gln?Phe?Pro?Ala?Gly?Glu?Ser?His?Glu?Ser?Leu?Gly?Leu?Asp?Gly

500 505 510

acc?gag?acc?ttc?gac?atc?acc?gga?ctg?acc?gca?ctt?aac?gag?ggc?gag 1584

Thr?Glu?Thr?Phe?Asp?Ile?Thr?Gly?Leu?Thr?Ala?Leu?Asn?Glu?Gly?Glu

515 520 525

act?cct?aag?act?gtc?aag?gtc?acc?gca?acc?aag?gag?aac?ggc?gac?gtc 1632

Thr?Pro?Lys?Thr?Val?Lys?Val?Thr?Ala?Thr?Lys?Glu?Asn?Gly?Asp?Val

530 535 540

gtc?gag?ttc?gac?gca?att?tgt?ccg?cat?cga?cac?ccc?agg?tgaggctgac 1681

Val?Glu?Phe?Asp?Ala?Ile?Cys?Pro?His?Arg?His?Pro?Arg

545 550 555

tactaccgcc?acg 1694

<210>554

<211>557

<212>PRT

＜2 13〉Corynebacterium glutamicum

<400>?554

Thr?Glu?Ser?Thr?Val?Val?Pro?Ser?Ile?Ala?Gly?Pro?Lys?Arg?Pro?Gln

1 5 10 15

Asp?Arg?Ile?Leu?Leu?Ser?Glu?Ala?Lys?Glu?Gln?Phe?Arg?Lys?Asp?Leu

20 25 30

Pro?Thr?Tyr?Thr?Asp?Asp?Ala?Val?Ser?Val?Asp?Thr?Ser?Ile?Pro?Ala

35 40 45

Thr?Arg?Met?Val?Asn?Glu?Gly?Gly?Gly?Gln?Pro?Glu?Gly?Gly?Val?Glu

50 55 60

Ala?Asp?Asn?Tyr?Asn?Ala?Ser?Trp?Ala?Gly?Ser?Gly?Glu?Ser?Leu?Ala

65 70 75 80

Thr?Gly?Ala?Glu?Gly?Arg?Pro?Ser?Lys?Pro?Val?Thr?Val?Ala?Ser?Pro

85 90 95

Gln?Gly?Gly?Glu?Tyr?Thr?Ile?Asp?His?Gly?Met?Val?Ala?Ile?Ala?Ser

100 105 110

Ile?Thr?Ser?Cys?Thr?Asn?Thr?Ser?Asn?Pro?Ser?Val?Met?Ile?Gly?Ala

115 120 125

Gly?Leu?Ile?Ala?Arg?Lys?Ala?Ala?Glu?Lys?Gly?Leu?Lys?Ser?Lys?Pro

130 135 140

Trp?Val?Lys?Thr?Ile?Cys?Ala?Pro?Gly?Ser?Gln?Val?Val?Asp?Gly?Tyr

145 150 155 160

Tyr?Gln?Arg?Ala?Asp?Leu?Trp?Lys?Asp?Leu?Glu?Ala?Met?Gly?Phe?Tyr

165 170 175

Leu?Ser?Gly?Phe?Gly?Cys?Thr?Thr?Cys?Ile?Gly?Asn?Ser?Gly?Pro?Leu

180 185 190

Pro?Glu?Glu?Ile?Ser?Ala?Ala?Ile?Asn?Glu?His?Asp?Leu?Thr?Ala?Thr

195 200 205

Ala?Val?Leu?Ser?Gly?Asn?Arg?Asn?Phe?Glu?Gly?Arg?Ile?Ser?Pro?Asp

210 215 220

Val?Lys?Met?Asn?Tyr?Leu?Ala?Ser?Pro?Ile?Met?Val?Ile?Ala?Tyr?Ala

225 230 235 240

Ile?Ala?Gly?Thr?Met?Asp?Phe?Asp?Phe?Glu?Asn?Glu?Ala?Leu?Gly?Gln

245 250 255

Asp?Gln?Asp?Gly?Asn?Asp?Val?Phe?Leu?Lys?Asp?Ile?Trp?Pro?Ser?Thr

260 265 270

Glu?Glu?Ile?Glu?Asp?Thr?Ile?Gln?Gln?Ala?Ile?Ser?Arg?Glu?Leu?Tyr

275 280 285

Glu?Ala?Asp?Tyr?Ala?Asp?Val?Phe?Lys?Gly?Asp?Lys?Gln?Trp?Gln?Glu

290 295 300

Leu?Asp?Val?Pro?Thr?Gly?Asp?Thr?Phe?Glu?Trp?Asp?Glu?Asn?Ser?Thr

305 310 315 320

Tyr?Ile?Arg?Lys?Ala?Pro?Tyr?Phe?Asp?Gly?Met?Pro?Val?Glu?Pro?Val

325 330 335

Ala?Val?Thr?Asp?Ile?Gln?Gly?Ala?Arg?Val?Leu?Ala?Lys?Leu?Gly?Asp

340 345 350

Ser?Val?Thr?Thr?Asp?His?Ile?Ser?Pro?Ala?Ser?Ser?Ile?Lys?Pro?Gly

355 360 365

Thr?Pro?Ala?Ala?Gln?Tyr?Leu?Asp?Glu?His?Gly?Val?Glu?Arg?His?Asp

370 375 380

Tyr?Asn?Ser?Leu?Gly?Ser?Arg?Arg?Gly?Asn?His?Glu?Val?Met?Met?Arg

385 390 395 400

Gly?Thr?Phe?Ala?Asn?Ile?Arg?Leu?Gln?Asn?Gln?Leu?Val?Asp?Ile?Ala

405 410 415

Gly?Gly?Tyr?Thr?Arg?Asp?Phe?Thr?Gln?Glu?Gly?Ala?Pro?Gln?Ala?Phe

420 425 430

Ile?Tyr?Asp?Ala?Ser?Val?Asn?Tyr?Lys?Ala?Ala?Gly?Ile?Pro?Leu?Val

435 440 445

Val?Leu?Gly?Gly?Lys?Glu?Tyr?Gly?Thr?Gly?Ser?Ser?Arg?Asp?Trp?Ala

450 455 460

Ala?Lys?Gly?Thr?Asn?Leu?Leu?Gly?Ile?Arg?Ala?Val?Ile?Thr?Glu?Ser

465 470 475 480

Phe?Glu?Arg?Ile?His?Arg?Ser?Asn?Leu?Ile?Gly?Met?Gly?Val?Val?Pro

485 490 495

Leu?Gln?Phe?Pro?Ala?Gly?Glu?Ser?His?Glu?Ser?Leu?Gly?Leu?Asp?Gly

500 505 510

Thr?Glu?Thr?Phe?Asp?Ile?Thr?Gly?Leu?Thr?Ala?Leu?Asn?Glu?Gly?Glu

515 520 525

Thr?Pro?Lys?Thr?Val?Lys?Val?Thr?Ala?Thr?Lys?Glu?Asn?Gly?Asp?Val

530 535 540

Val?Glu?Phe?Asp?Ala?Ile?Cys?Pro?His?Arg?His?Pro?Arg

545 550 555

<210>555

<211>1682

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(1659)

<223>FRXA02209

<400>555

gtt?gtt?cct?tcc?atc?gct?ggc?cct?aag?cgc?cca?cag?gac?cgc?atc?ctt 48

Val?Val?Pro?Ser?Ile?Ala?Gly?Pro?Lys?Arg?Pro?Gln?Asp?Arg?Ile?Leu

1 5 10 15

ctc?tcc?gag?gca?aag?gag?cag?ttc?cgt?aag?gat?ctg?cca?acc?tac?acc 96

Leu?Ser?Glu?Ala?Lys?Glu?Gln?Phe?Arg?Lys?Asp?Leu?Pro?Thr?Tyr?Thr

20 25 30

gac?gac?gct?gtt?tcc?gta?gac?acc?tcc?atc?cct?gca?acc?cgc?atg?gtt 144

Asp?Asp?Ala?Val?Ser?Val?Asp?Thr?Ser?Ile?Pro?Ala?Thr?Arg?Met?Val

35 40 45

aac?gaa?ggt?ggc?gga?cag?cct?gaa?ggc?ggc?gtc?gaa?gct?gac?aac?tac 192

Asn?Glu?Gly?Gly?Gly?Gln?Pro?Glu?Gly?Gly?Val?Glu?Ala?Asp?Asn?Tyr

50 55 60

aac?gct?tcc?tgg?gct?ggc?tcc?ggc?gag?tcc?ttg?gct?act?ggc?gca?gaa 240

Asn?Ala?Ser?Trp?Ala?Gly?Ser?Gly?Glu?Ser?Leu?Ala?Thr?Gly?Ala?Glu

65 70 75 80

gga?cgt?cct?tcc?aag?cca?gtc?acc?gtt?gca?tcc?cca?cag?ggt?ggc?gag 288

Gly?Arg?Pro?Ser?Lys?Pro?Val?Thr?Val?Ala?Ser?Pro?Gln?Gly?Gly?Glu

85 90 95

tac?acc?atc?gac?cac?ggc?atg?gtt?gca?att?gca?tcc?atc?acc?tct?tgc 336

Tyr?Thr?Ile?Asp?His?Gly?Met?Val?Ala?Ile?Ala?Ser?Ile?Thr?Ser?Cys

100 105 110

acc?aac?acc?tct?aac?cca?tcc?gtg?atg?atc?ggc?gct?ggc?ctg?atc?gca 384

Thr?Asn?Thr?Ser?Asn?Pro?Ser?Val?Met?Ile?Gly?Ala?Gly?Leu?Ile?Ala

115 120 125

cgt?aag?gca?gca?gaa?aag?ggc?ctc?aag?tcc?aag?cct?tgg?gtt?aag?acc 432

Arg?Lys?Ala?Ala?Glu?Lys?Gly?Leu?Lys?Ser?Lys?Pro?Trp?Val?Lys?Thr

130 135 140

atc?tgt?gca?cca?ggt?tcc?cag?gtt?gtc?gac?ggc?tac?tac?cag?cgc?gca 480

Ile?Cys?Ala?Pro?Gly?Ser?Gln?Val?Val?Asp?Gly?Tyr?Tyr?Gln?Arg?Ala

145 150 155 160

gac?ctc?tgg?aag?gac?ctt?gag?gcc?atg?ggc?ttc?tac?ctc?tcc?ggc?ttc 528

Asp?Leu?Trp?Lys?Asp?Leu?Glu?Ala?Met?Gly?Phe?Tyr?Leu?Ser?Gly?Phe

165 170 175

ggc?tgc?acc?acc?tgt?att?ggt?aac?tcc?ggc?cca?ctg?cca?gag?gaa?atc 576

Gly?Cys?Thr?Thr?Cys?Ile?Gly?Asn?Ser?Gly?Pro?Leu?Pro?Glu?Glu?Ile

180 185 190

tcc?gct?gcg?atc?aac?gag?cac?gac?ctg?acc?gca?acc?gca?gtt?ttg?tcc 624

Ser?Ala?Ala?Ile?Asn?Glu?His?Asp?Leu?Thr?Ala?Thr?Ala?Val?Leu?Ser

195 200 205

ggt?aac?cgt?aac?ttc?gag?gga?cgt?atc?tcc?cct?gac?gtt?aag?atg?aac 672

Gly?Asn?Arg?Asn?Phe?Glu?Gly?Arg?Ile?Ser?Pro?Asp?Val?Lys?Met?Asn

210 215 220

tac?ctg?gca?tcc?cca?atc?atg?gtc?att?gct?tac?gca?atc?gct?ggc?acc 720

Tyr?Leu?Ala?Ser?Pro?Ile?Met?Val?Ile?Ala?Tyr?Ala?Ile?Ala?Gly?Thr

225 230 235 240

atg?gac?ttc?gac?ttc?gag?aac?gaa?gct?ctt?gga?cag?gac?cag?gac?ggc 768

Met?Asp?Phe?Asp?Phe?Glu?Asn?Glu?Ala?Leu?Gly?Gln?Asp?Gln?Asp?Gly

245 250 255

aac?gac?gtc?ttc?ctg?aag?gac?atc?tgg?cct?tcc?acc?gag?gaa?atc?gaa 816

Asn?Asp?Val?Phe?Leu?Lys?Asp?Ile?Trp?Pro?Ser?Thr?Glu?Glu?Ile?Glu

260 265 270

gac?acc?atc?cag?cag?gca?atc?tcc?cgt?gag?ctt?tac?gaa?gct?gac?tac 864

Asp?Thr?Ile?Gln?Gln?Ala?Ile?Ser?Arg?Glu?Leu?Tyr?Glu?Ala?Asp?Tyr

275 280 285

gca?gat?gtc?ttc?aag?ggt?gac?aag?cag?tgg?cag?gaa?ctc?gat?gtt?cct 912

Ala?Asp?Val?Phe?Lys?Gly?Asp?Lys?Gln?Trp?Gln?Glu?Leu?Asp?Val?Pro

290 295 300

acc?ggt?gac?acc?ttc?gag?tgg?gac?gag?aac?tcc?acc?tac?atc?cgc?aag 960

Thr?Gly?Asp?Thr?Phe?Glu?Trp?Asp?Glu?Asn?Ser?Thr?Tyr?Ile?Arg?Lys

305 310 315 320

gca?cct?tac?ttc?gac?ggc?atg?cct?gtc?gag?cca?gtg?gca?gtc?acc?gac 1008

Ala?Pro?Tyr?Phe?Asp?Gly?Met?Pro?Val?Glu?Pro?Val?Ala?Val?Thr?Asp

325 330 335

atc?cag?ggc?gca?cgc?gtt?ctg?gct?aag?ctc?ggc?gac?tct?gtc?acc?acc 1056

Ile?Gln?Gly?Ala?Arg?Val?Leu?Ala?Lys?Leu?Gly?Asp?Ser?Val?Thr?Thr

340 345 350

gac?cac?atc?tcc?cct?gct?tcc?tcc?att?aag?cca?ggt?acc?cct?gca?gct 1104

Asp?His?Ile?Ser?Pro?Ala?Ser?Ser?Ile?Lys?Pro?Gly?Thr?Pro?Ala?Ala

355 360 365

cag?tac?ttg?gat?gag?cac?ggt?gtg?gaa?cgc?cac?gac?tac?aac?tcc?ctg 1152

Gln?Tyr?Leu?Asp?Glu?His?Gly?Val?Glu?Arg?His?Asp?Tyr?Asn?Ser?Leu

370 375 380

ggt?tcc?agg?cgt?ggt?aac?cac?gag?gtc?atg?atg?cgc?ggc?acc?ttc?gcc 1200

Gly?Ser?Arg?Arg?Gly?Asn?His?Glu?Val?Met?Met?Arg?Gly?Thr?Phe?Ala

385 390 395 400

aac?atc?cgc?ctc?cag?aac?cag?ctg?gtt?gac?atc?gca?ggt?ggc?tac?acc 1248

Asn?Ile?Arg?Leu?Gln?Asn?Gln?Leu?Val?Asp?Ile?Ala?Gly?Gly?Tyr?Thr

405 410 415

cgc?gac?ttc?acc?cag?gag?ggt?gct?cca?cag?gcg?ttc?atc?tac?gac?gct 129G

Arg?Asp?Phe?Thr?Gln?Glu?Gly?Ala?Pro?Gln?Ala?Phe?Ile?Tyr?Asp?Ala

420 425 430

tcc?gtc?aac?tac?aag?gct?gct?ggc?att?ccg?ctg?gtc?gtc?ttg?ggc?ggc 1344

Ser?Val?Asn?Tyr?Lys?Ala?Ala?Gly?Ile?Pro?Leu?Val?Val?Leu?Gly?Gly

435 440 445

aag?gag?tac?ggc?acc?ggt?tct?tcc?cgt?gac?tgg?gca?gct?aag?ggc?act 1392

Lys?Glu?Tyr?Gly?Thr?Gly?Ser?Ser?Arg?Asp?Trp?Ala?Ala?Lys?Gly?Thr

450 455 460

aac?ctg?ctc?gga?att?cgc?gca?gtt?atc?acc?gag?tcc?ttc?gag?cgt?att 1440

Asn?Leu?Leu?Gly?Ile?Arg?Ala?Val?Ile?Thr?Glu?Ser?Phe?Glu?Arg?Ile

465 470 475 480

cac?cgc?tcc?aac?ctc?atc?ggt?atg?ggc?gtt?gtc?cca?ctg?cag?ttc?cct 1488

His?Arg?Ser?Asn?Leu?Ile?Gly?Met?Gly?Val?Val?Pro?Leu?Gln?Phe?Pro

485 490 495

gca?ggc?gaa?tcc?cac?gag?tcc?ctg?ggc?ctt?gac?ggc?acc?gag?acc?ttc 1536

Ala?Gly?Glu?Ser?His?Glu?Ser?Leu?Gly?Leu?Asp?Gly?Thr?Glu?Thr?Phe

500 505 510

gac?atc?acc?gga?ctg?acc?gca?ctt?aac?gag?ggc?gag?act?cct?aag?act 1584

Asp?Ile?Thr?Gly?Leu?Thr?Ala?Leu?Asn?Glu?Gly?Glu?Thr?Pro?Lys?Thr

515 520 525

gtc?aag?gtc?acc?gca?acc?aag?gag?aac?ggc?gac?gtc?gtc?gag?ttc?gac 1632

Val?Lys?Val?Thr?Ala?Thr?Lys?Glu?Asn?Gly?Asp?Val?Val?Glu?Phe?Asp

530 535 540

gca?att?tgt?ccg?cat?cga?cac?ccc?agg?tgaggctgac?tactaccgcc 1679

Ala?Ile?Cys?Pro?His?Arg?His?Pro?Arg

545 550

acg 1682

<210>556

<211>553

<212>PRT

＜213〉Corynebacterium glutamicum

<400>556

Val?Val?Pro?Ser?Ile?Ala?Gly?Pro?Lys?Arg?Pro?Gln?Asp?Arg?Ile?Leu

1 5 10 15

Leu?Ser?Glu?Ala?Lys?Glu?Gln?Phe?Arg?Lys?Asp?Leu?Pro?Thr?Tyr?Thr

20 25 30

Asp?Asp?Ala?Val?Ser?Val?Asp?Thr?Ser?Ile?Pro?Ala?Thr?Arg?Met?Val

35 40 45

Asn?Glu?Gly?Gly?Gly?Gln?Pro?Glu?Gly?Gly?Val?Glu?Ala?Asp?Asn?Tyr

50 55 60

Asn?Ala?Ser?Trp?Ala?Gly?Ser?Gly?Glu?Ser?Leu?Ala?Thr?Gly?Ala?Glu

65 70 75 80

Gly?Arg?Pro?Ser?Lys?Pro?Val?Thr?Val?Ala?Ser?Pro?Gln?Gly?Gly?Glu

85 90 95

Tyr?Thr?Ile?Asp?His?Gly?Met?Val?Ala?Ile?Ala?Ser?Ile?Thr?Ser?Cys

100 105 110

Thr?Asn?Thr?Ser?Asn?Pro?Ser?Val?Met?Ile?Gly?Ala?Gly?Leu?Ile?Ala

115 120 125

Arg?Lys?Ala?Ala?Glu?Lys?Gly?Leu?Lys?Ser?Lys?Pro?Trp?Val?Lys?Thr

130 135 140

Ile?Cys?Ala?Pro?Gly?Ser?Gln?Val?Val?Asp?Gly?Tyr?Tyr?Gln?Arg?Ala

145 150 155 160

Asp?Leu?Trp?Lys?Asp?Leu?Glu?Ala?Met?Gly?Phe?Tyr?Leu?Ser?Gly?Phe

165 170 175

Gly?Cys?Thr?Thr?Cys?Ile?Gly?Asn?Ser?Gly?Pro?Leu?Pro?Glu?Glu?Ile

180 185 190

Ser?Ala?Ala?Ile?Asn?Glu?His?Asp?Leu?Thr?Ala?Thr?Ala?Val?Leu?Ser

195 200 205

Gly?Asn?Arg?Asn?Phe?Glu?Gly?Arg?Ile?Ser?Pro?Asp?Val?Lys?Met?Asn

210 215 220

Tyr?Leu?Ala?Ser?Pro?Ile?Met?Val?Ile?Ala?Tyr?Ala?Ile?Ala?Gly?Thr

225 230 235 240

Met?Asp?Phe?Asp?Phe?Glu?Asn?Glu?Ala?Leu?Gly?Gln?Asp?Gln?Asp?Gly

245 250 255

Asn?Asp?Val?Phe?Leu?Lys?Asp?Ile?Trp?Pro?Ser?Thr?Glu?Glu?Ile?Glu

260 265 270

Asp?Thr?Ile?Gln?Gln?Ala?Ile?Ser?Arg?Glu?Leu?Tyr?Glu?Ala?Asp?Tyr

275 280 285

Ala?Asp?Val?Phe?Lys?Gly?Asp?Lys?Gln?Trp?Gln?Glu?Leu?Asp?Val?Pro

290 295 300

Thr?Gly?Asp?Thr?Phe?Glu?Trp?Asp?Glu?Asn?Ser?Thr?Tyr?Ile?Arg?Lys

305 310 315 320

Ala?Pro?Tyr?Phe?Asp?Gly?Met?Pro?Val?Glu?Pro?Val?Ala?Val?Thr?Asp

325 330 335

Ile?Gln?Gly?Ala?Arg?Val?Leu?Ala?Lys?Leu?Gly?Asp?Ser?Val?Thr?Thr

340 345 350

Asp?His?Ile?Ser?Pro?Ala?Ser?Ser?Ile?Lys?Pro?Gly?Thr?Pro?Ala?Ala

355 360 365

Gln?Tyr?Leu?Asp?Glu?His?Gly?Val?Glu?Arg?His?Asp?Tyr?Asn?Ser?Leu

370 375 380

Gly?Ser?Arg?Arg?Gly?Asn?His?Glu?Val?Met?Met?Arg?Gly?Thr?Phe?Ala

385 390 395 400

Asn?Ile?Arg?Leu?Gln?Asn?Gln?Leu?Val?Asp?Ile?Ala?Gly?Gly?Tyr?Thr

405 410 415

Arg?Asp?Phe?Thr?Gln?Glu?Gly?Ala?Pro?Gln?Ala?Phe?Ile?Tyr?Asp?Ala

420 425 430

Ser?Val?Asn?Tyr?Lys?Ala?Ala?Gly?Ile?Pro?Leu?Val?Val?Leu?Gly?Gly

435 440 445

Lys?Glu?Tyr?Gly?Thr?Gly?Ser?Ser?Arg?Asp?Trp?Ala?Ala?Lys?Gly?Thr

450 455 460

Asn?Leu?Leu?Gly?Ile?Arg?Ala?Val?Ile?Thr?Glu?Ser?Phe?Glu?Arg?Ile

465 470 475 480

His?Arg?Ser?Asn?Leu?Ile?Gly?Met?Gly?Val?Val?Pro?Leu?Gln?Phe?Pro

485 490 495

Ala?Gly?Glu?Ser?His?Glu?Ser?Leu?Gly?Leu?Asp?Gly?Thr?Glu?Thr?Phe

500 505 510

Asp?Ile?Thr?Gly?Leu?Thr?Ala?Leu?Asn?Glu?Gly?Glu?Thr?Pro?Lys?Thr

515 520 525

Val?Lys?Val?Thr?Ala?Thr?Lys?Glu?Asn?Gly?Asp?Val?Val?Glu?Phe?Asp

530 535 540

Ala?Ile?Cys?Pro?His?Arg?His?Pro?Arg

545 550

<210>557

<211>874

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(874)

<223>RXN02213

<400>?557

ttctgtggaa?tgagaatccg?atgtttttct?cacgccggct?cagccgaagc?agacgccgtc?60

gcgaaatctc?accctaaaaa?agttagaatt?ggagctcact?gtg?act?gaa?agc?aag 115

Val?Thr?Glu?Ser?Lys

1 5

aac?tcc?ttc?aat?gct?aag?agc?acc?ctt?gaa?gtt?ggc?gac?aag?tcc?tat 163

Asn?Ser?Phe?Asn?Ala?Lys?Ser?Thr?Leu?Glu?Val?Gly?Asp?Lys?Ser?Tyr

10 15 20

gac?tac?ttc?gcc?ctc?tct?gca?gtg?cct?ggc?atg?gag?aag?ctg?ccg?tac 211

Asp?Tyr?Phe?Ala?Leu?Ser?Ala?Val?Pro?Gly?Met?Glu?Lys?Leu?Pro?Tyr

25 30 35

tcc?ctc?aag?gtt?ctc?gga?gag?aac?ctt?ctt?cgt?acc?gaa?gac?ggc?gca 259

Ser?Leu?Lys?Val?Leu?Gly?Glu?Asn?Leu?Leu?Arg?Thr?Glu?Asp?Gly?Ala

40 45 50

aac?atc?acc?aac?gag?cac?att?gag?gct?atc?gcc?aac?tgg?gat?gca?tct 307

Asn?Ile?Thr?Asn?Glu?His?Ile?Glu?Ala?Ile?Ala?Asn?Trp?Asp?Ala?Ser

55 60 65

tcc?gat?cca?agc?atc?gaa?atc?cag?ttc?acc?cca?gcc?cgt?gtt?ctc?atg 355

Ser?Asp?Pro?Ser?Ile?Glu?Ile?Gln?Phe?Thr?Pro?Ala?Arg?Val?Leu?Met

70 75 80 85

cag?gac?ttc?acc?ggt?gtc?cct?tgt?gta?gtt?gac?ctc?gca?acc?atg?cgt 403

Gln?Asp?Phe?Thr?Gly?Val?Pro?Cys?Val?Val?Asp?Leu?Ala?Thr?Met?Arg

90 95 100

gag?gca?gtt?gct?gca?ctc?ggt?ggc?gac?cct?aac?gac?gtc?aac?cca?ctg 451

Glu?Ala?Val?Ala?Ala?Leu?Gly?Gly?Asp?Pro?Asn?Asp?Val?Asn?Pro?Leu

105 110 115

aac?cca?gcc?gag?atg?gtc?att?gac?cac?tcc?gtc?atc?gtg?gag?gct?ttc 499

Asn?Pro?Ala?Glu?Met?Val?Ile?Asp?His?Ser?Val?Ile?Val?Glu?Ala?Phe

120 125 130

ggc?cgc?cca?gat?gca?ctg?gct?aag?aac?gtt?gag?atc?gag?tac?gag?cgc 547

Gly?Arg?Pro?Asp?Ala?Leu?Ala?Lys?Asn?Val?Glu?Ile?Glu?Tyr?Glu?Arg

135 140 145

aac?gag?gag?cgt?tac?cag?ttc?ctg?cgt?tgg?ggt?tcc?gag?tcc?ttc?tcc 595

Asn?Glu?Glu?Arg?Tyr?Gln?Phe?Leu?Arg?Trp?Gly?Ser?Glu?Ser?Phe?Ser

150 155 160 165

aac?ttc?cgc?gtt?gtt?cct?cca?gga?acc?ggt?atc?gtc?cac?cag?gtc?aac 643

Asn?Phe?Arg?Val?Val?Pro?Pro?Gly?Thr?Gly?Ile?Val?His?Gln?Val?Asn

170 175 180

att?gag?tac?ttg?gct?cgc?gtc?gtc?ttc?gac?aac?gag?ggc?ctt?gca?tac 691

Ile?Glu?Tyr?Leu?Ala?Arg?Val?Val?Phe?Asp?Asn?Glu?Gly?Leu?Ala?Tyr

185 190 195

cca?gat?acc?tgc?atc?ggt?acc?gac?tcc?cac?acc?acc?atg?gaa?aac?ggc 739

Pro?Asp?Thr?Cys?Ile?Gly?Thr?Asp?Ser?His?Thr?Thr?Met?Glu?Asn?Gly

200 205 210

ctg?ggc?atc?ctg?ggc?tgg?ggc?gtt?ggt?ggc?att?gag?gct?gaa?gca?gca 787

Leu?Gly?Ile?Leu?Gly?Trp?Gly?Val?Gly?Gly?Ile?Glu?Ala?Glu?Ala?Ala

215 220 225

atg?ctc?ggc?cag?cca?gtg?tcc?atg?ctg?atc?cct?cgc?gtt?gtt?ggc?ttc 835

Met?Leu?Gly?Gln?Pro?Val?Ser?Met?Leu?Ile?Pro?Arg?Val?Val?Gly?Phe

230 235 240 245

aag?ttg?acc?ggc?gag?atc?cca?gta?ggc?gtt?acc?gca?act 874

Lys?Leu?Thr?Gly?Glu?Ile?Pro?Val?Gly?Val?Thr?Ala?Thr

250 255

<210>558

<211>258

<212>PRT

＜213〉Corynebacterium glutamicum

<400>558

Val?Thr?Glu?Ser?Lys?Asn?Ser?Phe?Asn?Ala?Lys?Ser?Thr?Leu?Glu?Val

1 5 10 15

Gly?Asp?Lys?Ser?Tyr?Asp?Tyr?Phe?Ala?Leu?Ser?Ala?Val?Pro?Gly?Met

20 25 30

Glu?Lys?Leu?Pro?Tyr?Ser?Leu?Lys?Val?Leu?Gly?Glu?Asn?Leu?Leu?Arg

35 40 45

Thr?Glu?Asp?Gly?Ala?Asn?Ile?Thr?Asn?Glu?His?Ile?Glu?Ala?Ile?Ala

50 55 60

Asn?Trp?Asp?Ala?Ser?Ser?Asp?Pro?Ser?Ile?Glu?Ile?Gln?Phe?Thr?Pro

65 70 75 80

Ala?Arg?Val?Leu?Met?Gln?Asp?Phe?Thr?Gly?Val?Pro?Cys?Val?Val?Asp

85 90 95

Leu?Ala?Thr?Met?Arg?Glu?Ala?Val?Ala?Ala?Leu?Gly?Gly?Asp?Pro?Asn

100 105 110

Asp?Val?Asn?Pro?Leu?Asn?Pro?Ala?Glu?Met?Val?Ile?Asp?His?Ser?Val

115 120 125

Ile?Val?Glu?Ala?Phe?Gly?Arg?Pro?Asp?Ala?Leu?Ala?Lys?Asn?Val?Glu

130 135 140

Ile?Glu?Tyr?Glu?Arg?Asn?Glu?Glu?Arg?Tyr?Gln?Phe?Leu?Arg?Trp?Gly

145 150 155 160

Ser?Glu?Ser?Phe?Ser?Asn?Phe?Arg?Val?Val?Pro?Pro?Gly?Thr?Gly?Ile

165 170 175

Val?His?Gln?Val?Asn?Ile?Glu?Tyr?Leu?Ala?Arg?Val?Val?Phe?Asp?Asn

180 185 190

Glu?Gly?Leu?Ala?Tyr?Pro?Asp?Thr?Cys?Ile?Gly?Thr?Asp?Ser?His?Thr

195 200 205

Thr?Met?Glu?Asn?Gly?Leu?Gly?Ile?Leu?Gly?Trp?Gly?Val?Gly?Gly?Ile

210 215 220

Glu?Ala?Glu?Ala?Ala?Met?Leu?Gly?Gln?Pro?Val?Ser?Met?Leu?Ile?Pro

225 230 235 240

Arg?Val?Val?Gly?Phe?Lys?Leu?Thr?Gly?Glu?Ile?Pro?Val?Gly?Val?Thr

245 250 255

Ala?Thr

<210>559

<211>817

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(817)

<223>FRXA02213

<400>559

ttctgtggaa?tgagaatccg?atgtttttct?cacgccggct?cagccgaagc?agacgccgtc?60

gcgaaatctc?accctaaaaa?agttagaatt?ggagctcact?gtg?act?gaa?agc?aag 115

Val?Thr?Glu?Ser?Lys

1 5

aac?tcc?ttc?aat?gct?aag?agc?acc?ctt?gaa?gtt?ggc?gac?aag?tcc?tat 163

Asn?Ser?Phe?Asn?Ala?Lys?Ser?Thr?Leu?Glu?Val?Gly?Asp?Lys?Ser?Tyr

10 15 20

gac?tac?ttc?gcc?ctc?tct?gca?gtg?cct?ggc?atg?gag?aag?ctg?ccg?tac 211

Asp?Tyr?Phe?Ala?Leu?Ser?Ala?Val?Pro?Gly?Met?Glu?Lys?Leu?Pro?Tyr

25 30 35

tcc?ctc?aag?gtt?ctc?gga?gag?aac?ctt?ctt?cgt?acc?gaa?gac?ggc?gca 259

Ser?Leu?Lys?Val?Leu?Gly?Glu?Asn?Leu?Leu?Arg?Thr?Glu?Asp?Gly?Ala

40 45 50

aac?atc?acc?aac?gag?cac?att?gag?gct?atc?gcc?aac?tgg?gat?gca?tct 307

Asn?Ile?Thr?Asn?Glu?His?Ile?Glu?Ala?Ile?Ala?Asn?Trp?Asp?Ala?Ser

55 60 65

tcc?gat?cca?agc?atc?gaa?atc?cag?ttc?acc?cca?gcc?cgt?gtt?ctc?atg 355

Ser?Asp?Pro?Ser?Ile?Glu?Ile?Gln?Phe?Thr?Pro?Ala?Arg?Val?Leu?Met

70 75 80 85

cag?gac?ttc?acc?ggt?gtc?cct?tgt?gta?gtt?gac?ctc?gca?acc?atg?cgt 403

Gln?Asp?Phe?Thr?Gly?Val?Pro?Cys?Val?Val?Asp?Leu?Ala?Thr?Met?Arg

90 95 100

gag?gca?gtt?gct?gca?ctc?ggt?ggc?gac?cct?aac?gac?gtc?aac?cca?ctg 451

Glu?Ala?Val?Ala?Ala?Leu?Gly?Gly?Asp?Pro?Asn?Asp?Val?Asn?Pro?Leu

105 110 115

aac?cca?gcc?gag?atg?gtc?att?gac?cac?tcc?gtc?atc?gtg?gag?gct?ttc 499

Asn?Pro?Ala?Glu?Met?Val?Ile?Asp?His?Ser?Val?Ile?Val?Glu?Ala?Phe

120 125 130

ggc?cgc?cca?gat?gca?ctg?gct?aag?aac?gtt?gag?atc?gag?tac?gag?cgc 547

Gly?Arg?Pro?Asp?Ala?Leu?Ala?Lys?Asn?Val?Glu?Ile?Glu?Tyr?Glu?Arg

135 140 145

aac?gag?gag?cgt?tac?cag?ttc?ctg?cgt?tgg?ggt?tcc?gag?tcc?ttc?tcc 595

Asn?Glu?Glu?Arg?Tyr?Gln?Phe?Leu?Arg?Trp?Gly?Ser?Glu?Ser?Phe?Ser

150 155 160 165

aac?ttc?cgc?gtt?gtt?cct?cca?gga?acc?ggt?atc?gtc?cac?cag?gtc?aac 643

Asn?Phe?Arg?Val?Val?Pro?Pro?Gly?Thr?Gly?Ile?Val?His?Gln?Val?Asn

170 175 180

att?gag?tac?ttg?gct?cgc?gtc?gtc?ttc?gac?aac?gag?ggc?ctt?gca?tac 691

Ile?Glu?Tyr?Leu?Ala?Arg?Val?Val?Phe?Asp?Asn?Glu?Gly?Leu?Ala?Tyr

185 190 195

cca?gat?acc?tgc?atc?ggt?acc?gac?tcc?cac?acc?acc?atg?gaa?aac?ggc 739

Pro?Asp?Thr?Cys?Ile?Gly?Thr?Asp?Ser?His?Thr?Thr?Met?Glu?Asn?Gly

200 205 210

ctg?ggc?atc?ctg?ggc?tgg?ggc?gtt?ggt?ggc?att?gag?gct?gaa?gca?gca 787

Leu?Gly?Ile?Leu?Gly?Trp?Gly?Val?Gly?Gly?Ile?Glu?Ala?Glu?Ala?Ala

215 220 225

atg?ctc?ggc?cag?cca?gtg?tcc?atg?ctg?atc 817

Met?Leu?Gly?Gln?Pro?Val?Ser?Met?Leu?Ile

230 235

<210>560

<211>239

<212>PRT

＜213〉Corynebacterium glutamicum

<400>560

Val?Thr?Glu?Ser?Lys?Asn?Ser?Phe?Asn?Ala?Lys?Ser?Thr?Leu?Glu?Val

1 5 10 15

Gly?Asp?Lys?Ser?Tyr?Asp?Tyr?Phe?Ala?Leu?Ser?Ala?Val?Pro?Gly?Met

20 25 30

Glu?Lys?Leu?Pro?Tyr?Ser?Leu?Lys?Val?Leu?Gly?Glu?Asn?Leu?Leu?Arg

35 40 45

Thr?Glu?Asp?Gly?Ala?Asn?Ile?Thr?Asn?Glu?His?Ile?Glu?Ala?Ile?Ala

50 55 60

Asn?Trp?Asp?Ala?Ser?Ser?Asp?Pro?Ser?Ile?Glu?Ile?Gln?Phe?Thr?Pro

65 70 75 80

Ala?Arg?Val?Leu?Met?Gln?Asp?Phe?Thr?Gly?Val?Pro?Cys?Val?Val?Asp

85 90 95

Leu?Ala?Thr?Met?Arg?Glu?Ala?Val?Ala?Ala?Leu?Gly?Gly?Asp?Pro?Asn

100 105 110

Asp?Val?Asn?Pro?Leu?Asn?Pro?Ala?Glu?Met?Val?Ile?Asp?His?Ser?Val

115 120 125

Ile?Val?Glu?Ala?Phe?Gly?Arg?Pro?Asp?Ala?Leu?Ala?Lys?Asn?Val?Glu

130 135 140

Ile?Glu?Tyr?Glu?Arg?Asn?Glu?Glu?Arg?Tyr?Gln?Phe?Leu?Arg?Trp?Gly

145 150 155 160

Ser?Glu?Ser?Phe?Ser?Asn?Phe?Arg?Val?Val?Pro?Pro?Gly?Thr?Gly?Ile

165 170 175

Val?His?Gln?Val?Asn?Ile?Glu?Tyr?Leu?Ala?Arg?Val?Val?Phe?Asp?Asn

180 185 190

Glu?Gly?Leu?Ala?Tyr?Pro?Asp?Thr?Cys?Ile?Gly?Thr?Asp?Ser?His?Thr

195 200 205

Thr?Met?Glu?Asn?Gly?Leu?Gly?Ile?Leu?Gly?Trp?Gly?Val?Gly?Gly?Ile

210 215 220

Glu?Ala?Glu?Ala?Ala?Met?Leu?Gly?Gln?Pro?Val?Ser?Met?Leu?Ile

225 230 235

<210>561

<211>2891

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(2868)

<223>RXA02056

<400>561

cgc?cac?tct?gtt?cca?cgt?cta?acc?aag?ggc?cag?ggc?acc?atc?atc?ggt 48

Arg?His?Ser?Val?Pro?Arg?Leu?Thr?Lys?Gly?Gln?Gly?Thr?Ile?Ile?Gly

1 5 10 15

gtc?ggt?tcc?atg?gat?tac?cca?gca?gag?ttc?cag?ggc?gct?tca?gaa?gac 96

Val?Gly?Ser?Met?Asp?Tyr?Pro?Ala?Glu?Phe?Gln?Gly?Ala?Ser?Glu?Asp

20 25 30

cgc?ctt?gca?gag?ctc?ggc?gtt?ggc?aaa?ctt?gtc?acc?atc?acc?tcc?acc 144

Arg?Leu?Ala?Glu?Leu?Gly?Val?Gly?Lys?Leu?Val?Thr?Ile?Thr?Ser?Thr

35 40 45

tac?gat?cac?cgc?gtg?atc?cag?ggt?gct?gtg?tcc?ggt?gaa?ttc?ctg?cgc 192

Tyr?Asp?His?Arg?Val?Ile?Gln?Gly?Ala?Val?Ser?Gly?Glu?Phe?Leu?Arg

50 55 60

acc?atg?tct?cgc?ctg?ctc?acc?gat?gat?tcc?ttc?tgg?gat?gag?atc?ttc 240

Thr?Met?Ser?Arg?Leu?Leu?Thr?Asp?Asp?Ser?Phe?Trp?Asp?Glu?Ile?Phe

65 70 75 80

gac?gca?atg?aac?gtt?cct?tac?acc?cca?atg?cgt?tgg?gca?cag?gac?gtt 288

Asp?Ala?Met?Asn?Val?Pro?Tyr?Thr?Pro?Met?Arg?Trp?Ala?Gln?Asp?Val

85 90 95

cca?aac?acc?ggt?gtt?gat?aag?aac?acc?cgc?gtc?atg?cag?ctc?att?gag 336

Pro?Asn?Thr?Gly?Val?Asp?Lys?Asn?Thr?Arg?Val?Met?Gln?Leu?Ile?Glu

100 105 110

gca?tac?cgc?tcc?cgt?gga?cac?ctc?atc?gct?gac?acc?aac?cca?ctt?tca 384

Ala?Tyr?Arg?Ser?Arg?Gly?His?Leu?Ile?Ala?Asp?Thr?Asn?Pro?Leu?Ser

115 120 125

tgg?gtt?cag?cct?ggc?atg?cca?gtt?cca?gac?cac?cgc?gac?ctc?gac?atc 432

Trp?Val?Gln?Pro?Gly?Met?Pro?Val?Pro?Asp?His?Arg?Asp?Leu?Asp?Ile

130 135 140

gag?acc?cac?aac?ctg?acc?atc?tgg?gat?ctg?gac?cgt?acc?ttc?aac?gtc 480

Glu?Thr?His?Asn?Leu?Thr?Ile?Trp?Asp?Leu?Asp?Arg?Thr?Phe?Asn?Val

145 150 155 160

ggt?ggc?ttc?ggc?ggc?aag?gag?acc?atg?acc?ctg?cgc?gag?gta?ctg?tcc 528

Gly?Gly?Phe?Gly?Gly?Lys?Glu?Thr?Met?Thr?Leu?Arg?Glu?Val?Leu?Ser

165 170 175

cgc?ctc?cgc?gct?gcg?tac?acc?ctc?aag?gtc?ggc?tcc?gaa?tac?acc?cac 576

Arg?Leu?Arg?Ala?Ala?Tyr?Thr?Leu?Lys?Val?Gly?Ser?Glu?Tyr?Thr?His

180 185 190

atc?ctg?gac?cgc?gac?gag?cgc?acc?tgg?ctg?cag?gac?cgc?ctc?gag?gcc 624

Ile?Leu?Asp?Arg?Asp?Glu?Arg?Thr?Trp?Leu?Gln?Asp?Arg?Leu?Glu?Ala

195 200 205

gga?atg?cca?aag?cca?acc?cag?gca?gag?cag?aag?tac?atc?ctg?cag?aag 672

Gly?Met?Pro?Lys?Pro?Thr?Gln?Ala?Glu?Gln?Lys?Tyr?Ile?Leu?Gln?Lys

210 215 220

ctg?aac?gcc?gcg?gag?gct?ttc?gag?aac?ttc?ctg?cag?acc?aag?tac?gtc 720

Leu?Asn?Ala?Ala?Glu?Ala?Phe?Glu?Asn?Phe?Leu?Gln?Thr?Lys?Tyr?Val

225 230 235 240

ggc?cag?aag?cgc?ttc?tcc?ctc?gaa?ggt?gca?gaa?gca?ctt?atc?cca?ctg 768

Gly?Gln?Lys?Arg?Phe?Ser?Leu?Glu?Gly?Ala?Glu?Ala?Leu?Ile?Pro?Leu

245 250 255

atg?gac?tcc?gcc?atc?gac?acc?gcc?gca?ggc?caa?ggc?ctc?gac?gaa?gtt 816

Met?Asp?Ser?Ala?Ile?Asp?Thr?Ala?Ala?Gly?Gln?Gly?Leu?Asp?Glu?Val

260 265 270

gtc?atc?ggt?atg?cca?cac?cgt?ggt?cgc?ctc?aac?gtg?ctg?ttc?aac?atc 864

Val?Ile?Gly?Met?Pro?His?Arg?Gly?Arg?Leu?Asn?Val?Leu?Phe?Asn?Ile

275 280 285

gtg?ggc?aag?cca?ctg?gca?tcc?atc?ttc?aac?gag?ttt?gaa?ggc?caa?atg 912

Val?Gly?Lys?Pro?Leu?Ala?Ser?Ile?Phe?Asn?Glu?Phe?Glu?Gly?Gln?Met

290 295 300

gag?cag?ggc?cag?atc?ggt?ggc?tcc?ggt?gac?gtg?aag?tac?cac?ctc?ggt 960

Glu?Gln?Gly?Gln?Ile?Gly?Gly?Ser?Gly?Asp?Val?Lys?Tyr?His?Leu?Gly

305 310 315 320

tcc?gaa?ggc?cag?cac?ctg?cag?atg?ttc?ggc?gac?ggc?gag?atc?aag?gtc 1008

Ser?Glu?Gly?Gln?His?Leu?Gln?Met?Phe?Gly?Asp?Gly?Glu?Ile?Lys?Val

325 330 335

tcc?ctg?act?gct?aac?ccg?tcc?cac?ctg?gaa?gct?gtt?aac?cca?gcg?atg 1056

Ser?Leu?Thr?Ala?Asn?Pro?Ser?His?Leu?Glu?Ala?Val?Asn?Pro?Ala?Met

340 345 350

gaa?ggt?att?gtc?cgc?gca?aag?cag?gac?tac?ctg?gac?aag?ggc?gta?gac 1104

Glu?Gly?Ile?Val?Arg?Ala?Lys?Gln?Asp?Tyr?Leu?Asp?Lys?Gly?Val?Asp

355 360 365

ggc?aag?act?gtt?gtg?cca?ctg?ctg?ctc?cac?ggt?gac?gct?gca?ttc?gca 1152

Gly?Lys?Thr?Val?Val?Pro?Leu?Leu?Leu?His?Gly?Asp?Ala?Ala?Phe?Ala

370 375 380

ggc?ctg?ggc?atc?gtg?cca?gaa?acc?atc?aac?ctg?gct?aag?ctg?cgt?ggc 1200

Gly?Leu?Gly?Ile?Val?Pro?Glu?Thr?Ile?Asn?Leu?Ala?Lys?Leu?Arg?Gly

385 390 395 400

tac?gac?gtc?ggc?ggc?acc?atc?cac?atc?gtg?gtg?aac?aac?cag?atc?ggc 1248

Tyr?Asp?Val?Gly?Gly?Thr?Ile?His?Ile?Val?Val?Asn?Asn?Gin?Ile?Gly

405 410 415

ttc?acc?acc?acc?cca?gac?tcc?agc?cgc?tcc?atg?cac?tac?gca?acc?gac 1296

Phe?Thr?Thr?Thr?Pro?Asp?Ser?Ser?Arg?Ser?Met?His?Tyr?Ala?Thr?Asp

420 425 430

tac?gcc?aag?gca?ttc?ggc?tgc?cca?gtc?ttc?cac?gtc?aac?ggc?gac?gac 1344

Tyr?Ala?Lys?Ala?Phe?Gly?Cys?Pro?Val?Phe?His?Val?Asn?Gly?Asp?Asp

435 440 445

cca?gag?gca?gtt?gtc?tgg?gtt?ggc?cag?ctg?gcc?acc?gag?tac?cgt?cgt 1392

Pro?Glu?Ala?Val?Val?Trp?Val?Gly?Gln?Leu?Ala?Thr?Glu?Tyr?Arg?Arg

450 455 460

cgc?ttc?ggc?aag?gac?gtc?ttc?atc?gac?ctc?gtc?tgc?tac?cgc?ctc?cgc 1440

Arg?Phe?Gly?Lys?Asp?Val?Phe?Ile?Asp?Leu?Val?Cys?Tyr?Arg?Leu?Arg

465 470 475 480

ggc?cac?aac?gaa?gct?gat?gat?cct?tcc?atg?acc?cag?cca?aag?atg?tat 1488

Gly?His?Asn?Glu?Ala?Asp?Asp?Pro?Ser?Met?Thr?Gln?Pro?Lys?Met?Tyr

485 490 495

gag?ctc?atc?acc?ggc?cgc?gag?acc?gtt?cgt?gct?cag?tac?acc?gaa?gac 1536

Glu?Leu?Ile?Thr?Gly?Arg?Glu?Thr?Val?Arg?Ala?Gln?Tyr?Thr?Glu?Asp

500 505 510

ctg?ctc?gga?cgt?gga?gac?ctc?tcc?aac?gaa?gat?gca?gaa?gca?gtc?gtc 1584

Leu?Leu?Gly?Arg?Gly?Asp?Leu?Ser?Asn?Glu?Asp?Ala?Glu?Ala?Val?Val

515 520 525

cgc?gac?ttc?cac?gac?cag?atg?gaa?tct?gtg?ttc?aac?gaa?gtc?aag?gaa 1632

Arg?Asp?Phe?His?Asp?Gln?Met?Glu?Ser?Val?Phe?Asn?Glu?Val?Lys?Glu

530 535 540

ggc?ggc?aag?aag?cag?gct?gag?gca?cag?acc?ggc?atc?acc?ggc?tcc?cag 1680

Gly?Gly?Lys?Lys?Gln?Ala?Glu?Ala?Gln?Thr?Gly?Ile?Thr?Gly?Ser?Gln

545 550 555 560

aag?ctt?cca?cac?ggc?ctt?gag?acc?aac?atc?tcc?cgt?gaa?gag?ctc?ctg 1728

Lys?Leu?Pro?His?Gly?Leu?Glu?Thr?Asn?Ile?Ser?Arg?Glu?Glu?Leu?Leu

565 570 575

gaa?ctg?gga?cag?gct?ttc?gcc?aac?acc?cca?gaa?ggc?ttc?aac?tac?cac 1776

Glu?Leu?Gly?Gln?Ala?Phe?Ala?Asn?Thr?Pro?Glu?Gly?Phe?Asn?Tyr?His

580 585 590

cca?cgt?gtg?gct?ccc?gtt?gct?aag?aag?cgc?gtc?tcc?tct?gtc?acc?gaa 1824

Pro?Arg?Val?Ala?Pro?Val?Ala?Lys?Lys?Arg?Val?Ser?Ser?Val?Thr?Glu

595 600 605

ggt?ggc?atc?gac?tgg?gca?tgg?ggc?gag?ctc?ctc?gcc?ttc?ggt?tcc?ctg 1872

Gly?Gly?Ile?Asp?Trp?Ala?Trp?Gly?Glu?Leu?Leu?Ala?Phe?Gly?Ser?Leu

610 615 620

gct?aac?tcc?ggc?cgc?ttg?gtt?cgc?ctt?gca?ggt?gaa?gat?tcc?cgc?cgc 1920

Ala?Asn?Ser?Gly?Arg?Leu?Val?Arg?Leu?Ala?Gly?Glu?Asp?Ser?Arg?Arg

525 630 635 640

ggt?acc?ttc?acc?cag?cgc?cac?gca?gtt?gcc?atc?gac?cca?gcg?acc?gct 1968

Gly?Thr?Phe?Thr?Gln?Arg?His?Ala?Val?Ala?Ile?Asp?Pro?Ala?Thr?Ala

645 650 655

gaa?gag?ttc?aac?cca?ctc?cac?gag?ctt?gca?cag?tcc?aag?ggc?aac?aac 2016

Glu?Glu?Phe?Asn?Pro?Leu?His?Glu?Leu?Ala?Gln?Ser?Lys?Gly?Asn?Asn

660 665 670

ggt?aag?ttc?ctg?gtc?tac?aac?tcc?gca?ctg?acc?gag?tac?gca?ggc?atg 2064

Gly?Lys?Phe?Leu?Val?Tyr?Asn?Ser?Ala?Leu?Thr?Glu?Tyr?Ala?Gly?Met

675 680 685

ggc?ttc?gag?tac?ggc?tac?tcc?gta?gga?aac?gaa?gac?tcc?atc?gtt?gca 2112

Gly?Phe?Glu?Tyr?Gly?Tyr?Ser?Val?Gly?Asn?Glu?Asp?Ser?Ile?Val?Ala

690 695 700

tgg?gaa?gca?cag?ttc?ggc?gac?ttc?gcc?aac?ggc?gct?cag?acc?atc?atc 2160

Trp?Glu?Ala?Gln?Phe?Gly?Asp?Phe?Ala?Asn?Gly?Ala?Gln?Thr?Ile?Ile

705 710 715 720

gat?gag?tac?gtc?tcc?tca?ggc?gaa?gct?aag?tgg?ggc?cag?acc?tcc?aag 2208

Asp?Glu?Tyr?Val?Ser?Ser?Gly?Glu?Ala?Lys?Trp?Gly?Gln?Thr?Ser?Lys

725 730 735

ctg?atc?ctt?ctg?ctg?cct?cac?ggc?tac?gaa?ggc?cag?ggc?cca?gac?cac 2256

Leu?Ile?Leu?Leu?Leu?Pro?His?Gly?Tyr?Glu?Gly?Gln?Gly?Pro?Asp?His

740 745 750

tct?tcc?gca?cgt?atc?gag?cgc?ttc?ctg?cag?ctg?tgc?gct?gag?ggt?tcc 2304

Ser?Ser?Ala?Arg?Ile?Glu?Arg?Phe?Leu?Gln?Leu?Cys?Ala?Glu?Gly?Ser

755 760 765

atg?act?gtt?gct?cag?cca?tcc?acc?cca?gca?aac?cac?ttc?cac?cta?ctg 2352

Met?Thr?Val?Ala?Gln?Pro?Ser?Thr?Pro?Ala?Asn?His?Phe?His?Leu?Leu

770 775 780

cgt?cgt?cac?gct?ctg?tcc?gac?ctg?aag?cgt?cca?ctg?gtt?atc?ttc?acc 2400

Arg?Arg?His?Ala?Leu?Ser?Asp?Leu?Lys?Arg?Pro?Leu?Val?Ile?Phe?Thr

785 790 795 800

ccg?aag?tcc?atg?ctg?cgt?aac?aag?gct?gct?gcc?tcc?gca?cca?gaa?gac 2448

Pro?Lys?Ser?Met?Leu?Arg?Asn?Lys?Ala?Ala?Ala?Ser?Ala?Pro?Glu?Asp

805 810 815

ttc?act?gag?gtc?acc?aag?ttc?cag?tcc?gtg?atc?aac?gat?cca?aac?gtt 2496

Phe?Thr?Glu?Val?Thr?Lys?Phe?Gln?Ser?Val?Ile?Asn?Asp?Pro?Asn?Val

820 825 830

gca?gat?gca?gcc?aag?gtg?aag?aag?gtc?atg?ctg?gtc?tcc?ggc?aag?ctg 2544

Ala?Asp?Ala?Ala?Lys?Val?Lys?Lys?Val?Met?Leu?Val?Ser?Gly?Lys?Leu

835 840 845

tac?tac?gaa?ttg?gca?aag?cgc?aag?gag?aag?gac?gga?cgc?gac?gac?atc 2592

Tyr?Tyr?Glu?Leu?Ala?Lys?Arg?Lys?Glu?Lys?Asp?Gly?Arg?Asp?Asp?Ile

850 855 860

gcg?atc?gtt?cgt?atc?gaa?atg?ctc?cac?cca?att?ccg?ttc?aac?cgc?atc 2640

Ala?Ile?Val?Arg?Ile?Glu?Met?Leu?His?Pro?Ile?Pro?Phe?Asn?Arg?Ile

865 870 875 880

tcc?gag?gct?ctt?gcc?ggc?tac?cct?aac?gct?gag?gaa?gtc?ctc?ttc?gtt 2688

Ser?Glu?Ala?Leu?Ala?Gly?Tyr?Pro?Asn?Ala?Glu?Glu?Val?Leu?Phe?Val

885 890 895

cag?gat?gag?cca?gca?aac?cag?ggc?cca?tgg?ccg?ttc?tac?cag?gag?cac 2736

Gln?Asp?Glu?Pro?Ala?Asn?Gln?Gly?Pro?Trp?Pro?Phe?Tyr?Gln?Glu?His

900 905 910

ctc?cca?gag?ctg?atc?ccg?aac?atg?cca?aag?atg?cgc?cgc?gtt?tcc?cgc 2784

Leu?Pro?Glu?Leu?Ile?Pro?Asn?Met?Pro?Lys?Met?Arg?Arg?Val?Ser?Arg

915 920 925

cgc?gct?cag?tcc?tcc?acc?gca?act?ggt?gtt?gcc?aag?gtg?cac?cag?ctg 2832

Arg?Ala?Gln?Ser?Ser?Thr?Ala?Thr?Gly?Val?Ala?Lys?Val?His?Gln?Leu

930 935 940

gag?gag?aag?cag?ctt?atc?gac?gag?gct?ttc?gag?gct?taagtcttta 2878

Glu?Glu?Lys?Gln?Leu?Ile?Asp?Glu?Ala?Phe?Glu?Ala

945 950 955

tagtcctgca?cta 2891

<210>562

<211>956

<212>PRT

＜213〉Corynebacterium glutamicum

<400>?562

Arg?His?Ser?Val?Pro?Arg?Leu?Thr?Lys?Gly?Gln?Gly?Thr?Ile?Ile?Gly

1 5 10 15

Val?Gly?Ser?Met?Asp?Tyr?Pro?Ala?Glu?Phe?Gln?Gly?Ala?Ser?Glu?Asp

20 25 30

Arg?Leu?Ala?Glu?Leu?Gly?Val?Gly?Lys?Leu?Val?Thr?Ile?Thr?Ser?Thr

25 40 45

Tyr?Asp?His?Arg?Val?Ile?Gln?Gly?Ala?Val?Ser?Gly?Glu?Phe?Leu?Arg

50 55 60

Thr?Met?Ser?Arg?Leu?Leu?Thr?Asp?Asp?Ser?Phe?Trp?Asp?Glu?Ile?Phe

65 70 75 80

Asp?Ala?Met?Asn?Val?Pro?Tyr?Thr?Pro?Met?Arg?Trp?Ala?Gln?Asp?Val

85 90 95

Pro?Asn?Thr?Gly?Val?Asp?Lys?Asn?Thr?Arg?Val?Met?Gln?Leu?Ile?Glu

100 105 110

Ala?Tyr?Arg?Ser?Arg?Gly?His?Leu?Ile?Ala?Asp?Thr?Asn?Pro?Leu?Ser

115 120 125

Trp?Val?Gln?Pro?Gly?Met?Pro?Val?Pro?Asp?His?Arg?Asp?Leu?Asp?Ile

130 135 140

Glu?Thr?His?Asn?Leu?Thr?Ile?Trp?Asp?Leu?Asp?Arg?Thr?Phe?Asn?Val

145 150 155 160

Gly?Gly?Phe?Gly?Gly?Lys?Glu?Thr?Met?Thr?Leu?Arg?Glu?Val?Leu?Ser

165 170 175

Arg?Leu?Arg?Ala?Ala?Tyr?Thr?Leu?Lys?Val?Gly?Ser?Glu?Tyr?Thr?His

180 185 190

Ile?Leu?Asp?Arg?Asp?Glu?Arg?Thr?Trp?Leu?Gln?Asp?Arg?Leu?Glu?Ala

195 200 205

Gly?Met?Pro?Lys?Pro?Thr?Gln?Ala?Glu?Gln?Lys?Tyr?Ile?Leu?Gln?Lys

210 215 220

Leu?Asn?Ala?Ala?Glu?Ala?Phe?Glu?Asn?Phe?Leu?Gln?Thr?Lys?Tyr?Val

225 230 235 240

Gly?Gln?Lys?Arg?Phe?Ser?Leu?Glu?Gly?Ala?Glu?Ala?Leu?Ile?Pro?Leu

245 250 255

Met?Asp?Ser?Ala?Ile?Asp?Thr?Ala?Ala?Gly?Gln?Gly?Leu?Asp?Glu?Val

260 265 270

Val?Ile?Gly?Met?Pro?His?Arg?Gly?Arg?Leu?Asn?Val?Leu?Phe?Asn?Ile

275 280 285

Val?Gly?Lys?Pro?Leu?Ala?Ser?Ile?Phe?Asn?Glu?Phe?Glu?Gly?Gln?Met

290 295 300

Glu?Gln?Gly?Gln?Ile?Gly?Gly?Ser?Gly?Asp?Val?Lys?Tyr?His?Leu?Gly

305 310 315 320

Ser?Glu?Gly?Gln?His?Leu?Gln?Met?Phe?Gly?Asp?Gly?Glu?Ile?Lys?Val

325 330 335

Ser?Leu?Thr?Ala?Asn?Pro?Ser?His?Leu?Glu?Ala?Val?Asn?Pro?Ala?Met

340 345 350

Glu?Gly?Ile?Val?Arg?Ala?Lys?Gln?Asp?Tyr?Leu?Asp?Lys?Gly?Val?Asp

355 360 365

Gly?Lys?Thr?Val?Val?Pro?Leu?Leu?Leu?His?Gly?Asp?Ala?Ala?Phe?Ala

370 375 380

Gly?Leu?Gly?Ile?Val?Pro?Glu?Thr?Ile?Asn?Leu?Ala?Lys?Leu?Arg?Gly

385 390 395 400

Tyr?Asp?Val?Gly?Gly?Thr?Ile?His?Ile?Val?Val?Asn?Asn?Gln?Ile?Gly

405 410 415

Phe?Thr?Thr?Thr?Pro?Asp?Ser?Ser?Arg?Ser?Met?His?Tyr?Ala?Thr?Asp

420 425 430

Tyr?Ala?Lys?Ala?Phe?Gly?Cys?Pro?Val?Phe?His?Val?Asn?Gly?Asp?Asp

435 440 445

Pro?Glu?Ala?Val?Val?Trp?Val?Gly?Gln?Leu?Ala?Thr?Glu?Tyr?Arg?Arg

450 455 460

Arg?Phe?Gly?Lys?Asp?Val?Phe?Ile?Asp?Leu?Val?Cys?Tyr?Arg?Leu?Arg

465 470 475 480

Gly?His?Asn?Glu?Ala?Asp?Asp?Pro?Ser?Met?Thr?Gln?Pro?Lys?Met?Tyr

485 490 495

Glu?Leu?Ile?Thr?Gly?Arg?Glu?Thr?Val?Arg?Ala?Gln?Tyr?Thr?Glu?Asp

500 505 510

Leu?Leu?Gly?Arg?Gly?Asp?Leu?Ser?Asn?Glu?Asp?Ala?Glu?Ala?Val?Val

515 520 525

Arg?Asp?Phe?His?Asp?Gln?Met?Glu?Ser?Val?Phe?Asn?Glu?Val?Lys?Glu

530 535 540

Gly?Gly?Lys?Lys?Gln?Ala?Glu?Ala?Gln?Thr?Gly?Ile?Thr?Gly?Ser?Gln

545 550 555 560

Lys?Leu?Pro?His?Gly?Leu?Glu?Thr?Asn?Ile?Ser?Arg?Glu?Glu?Leu?Leu

565 570 575

Glu?Leu?Gly?Gln?Ala?Phe?Ala?Asn?Thr?Pro?Glu?Gly?Phe?Asn?Tyr?His

580 585 590

Pro?Arg?Val?Ala?Pro?Val?Ala?Lys?Lys?Arg?Val?Ser?Ser?Val?Thr?Glu

595 600 605

Gly?Gly?Ile?Asp?Trp?Ala?Trp?Gly?Glu?Leu?Leu?Ala?Phe?Gly?Ser?Leu

610 615 620

Ala?Asn?Ser?Gly?Arg?Leu?Val?Arg?Leu?Ala?Gly?Glu?Asp?Ser?Arg?Arg

625 630 635 640

Gly?Thr?Phe?Thr?Gln?Arg?His?Ala?Val?Ala?Ile?Asp?Pro?Ala?Thr?Ala

645 650 655

Glu?Glu?Phe?Asn?Pro?Leu?His?Glu?Leu?Ala?Gln?Ser?Lys?Gly?Asn?Asn

660 665 670

Gly?Lys?Phe?Leu?Val?Tyr?Asn?Ser?Ala?Leu?Thr?Glu?Tyr?Ala?Gly?Met

675 680 685

Gly?Phe?Glu?Tyr?Gly?Tyr?Ser?Val?Gly?Asn?Glu?Asp?Ser?Ile?Val?Ala

690 695 700

Trp?Glu?Ala?Gln?Phe?Gly?Asp?Phe?Ala?Asn?Gly?Ala?Gln?Thr?Ile?Ile

705 710 715 720

Asp?Glu?Tyr?Val?Ser?Ser?Gly?Glu?Ala?Lys?Trp?Gly?Gln?Thr?Ser?Lys

725 730 735

Leu?Ile?Leu?Leu?Leu?Pro?His?Gly?Tyr?Glu?Gly?Gln?Gly?Pro?Asp?His

740 745 750

Ser?Ser?Ala?Arg?Ile?Glu?Arg?Phe?Leu?Gln?Leu?Cys?Ala?Glu?Gly?Ser

755 760 765

Met?Thr?Val?Ala?Gln?Pro?Ser?Thr?Pro?Ala?Asn?His?Phe?His?Leu?Leu

770 775 780

Arg?Arg?His?Ala?Leu?Ser?Asp?Leu?Lys?Arg?Pro?Leu?Val?Ile?Phe?Thr

785 790 795 800

Pro?Lys?Ser?Met?Leu?Arg?Asn?Lys?Ala?Ala?Ala?Ser?Ala?Pro?Glu?Asp

805 810 815

Phe?Thr?Glu?Val?Thr?Lys?Phe?Gln?Ser?Val?Ile?Asn?Asp?Pro?Asn?Val

820 825 830

Ala?Asp?Ala?Ala?Lys?Val?Lys?Lys?Val?Met?Leu?Val?Ser?Gly?Lys?Leu

835 840 845

Tyr?Tyr?Glu?Leu?Ala?Lys?Arg?Lys?Glu?Lys?Asp?Gly?Arg?Asp?Asp?Ile

850 855 860

Ala?Ile?Val?Arg?Ile?Glu?Met?Leu?His?Pro?Ile?Pro?Phe?Asn?Arg?Ile

865 870 875 880

Ser?Glu?Ala?Leu?Ala?Gly?Tyr?Pro?Asn?Ala?Glu?Glu?Val?Leu?Phe?Val

885 890 895

Gln?Asp?Glu?Pro?Ala?Asn?Gln?Gly?Pro?Trp?Pro?Phe?Tyr?Gln?Glu?His

900 905 910

Leu?Pro?Glu?Leu?Ile?Pro?Asn?Met?Pro?Lys?Met?Arg?Arg?Val?Ser?Arg

915 920 925

Arg?Ala?Gln?Ser?Ser?Thr?Ala?Thr?Gly?Val?Ala?Lys?Val?His?Gln?Leu

930 935 940

Glu?Glu?Lys?Gln?Leu?Ile?Asp?Glu?Ala?Phe?Glu?Ala

945 950 955

<210>563

<211>1517

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(1494)

<223>RXA01745

<400>563

atc?ctt?gca?gac?gaa?gac?gac?acc?gtc?gac?gtc?ggc?gca?gtc?atc?gcc 48

Ile?Leu?Ala?Asp?Glu?Asp?Asp?Thr?Val?Asp?Val?Gly?Ala?Val?Ile?Ala

1 5 10 15

cgc?atc?ggt?gac?gca?aac?gca?gct?gca?gca?cct?gcc?gaa?gag?gaa?gca 96

Arg?Ile?Gly?Asp?Ala?Asn?Ala?Ala?Ala?Ala?Pro?Ala?Glu?Glu?Glu?Ala

20 25 30

gct?cct?gcc?gaa?gag?gaa?gaa?cca?gtt?aag?gaa?gag?cca?aag?aag?gag 144

Ala?Pro?Ala?Glu?Glu?Glu?Glu?Pro?Val?Lys?Glu?Glu?Pro?Lys?Lys?Glu

35 40 45

gca?gct?cct?gaa?gct?cca?gca?gca?act?ggc?gcc?gca?acc?gat?gtg?gaa 192

Ala?Ala?Pro?Glu?Ala?Pro?Ala?Ala?Thr?Gly?Ala?Ala?Thr?Asp?Val?Glu

50 55 60

atg?cca?gaa?ctc?ggc?gaa?tcc?gtc?acc?gaa?ggc?acc?att?acc?cag?tgg 240

Met?Pro?Glu?Leu?Gly?Glu?Ser?Val?Thr?Glu?Gly?Thr?Ile?Thr?Gln?Trp

65 70 75 80

ctc?aag?gct?gtc?ggc?gac?acc?gtc?gaa?gta?gac?gaa?cca?ctt?ctt?gag 288

Leu?Lys?Ala?Val?Gly?Asp?Thr?Val?Glu?Val?Asp?Glu?Pro?Leu?Leu?Glu

85 90 95

gtc?tcc?acc?gac?aag?gtc?gac?acc?gaa?atc?cca?tcc?cca?gta?gca?ggc 336

Val?Ser?Thr?Asp?Lys?Val?Asp?Thr?Glu?Ile?Pro?Ser?Pro?Val?Ala?Gly

100 105 110

acc?atc?gtg?gag?atc?ctt?gca?gac?gaa?gac?gac?acc?gtc?gac?gtc?ggc 384

Thr?Ile?Val?Glu?Ile?Leu?Ala?Asp?Glu?Asp?Asp?Thr?Val?Asp?Val?Gly

115 120 125

gca?gtc?atc?gcc?cgc?atc?ggt?gac?gca?aac?gca?gct?gca?gca?cct?gcc 432

Ala?Val?Ile?Ala?Arg?Ile?Gly?Asp?Ala?Asn?Ala?Ala?Ala?Ala?Pro?Ala

130 135 140

gaa?gag?gaa?gca?gct?cct?gcc?gaa?gag?gag?gaa?cca?gtt?aag?gaa?gag 480

Glu?Glu?Glu?Ala?Ala?Pro?Ala?Glu?Glu?Glu?Glu?Pro?Val?Lys?Glu?Glu

145 150 155 160

cca?aag?aag?gaa?gag?ccc?aag?aag?gaa?gag?ccc?aag?aag?gaa?gca?gct 528

Pro?Lys?Lys?Glu?Glu?Pro?Lys?Lys?Glu?Glu?Pro?Lys?Lys?Glu?Ala?Ala

165 170 175

act?aca?cct?gct?gcg?gca?tcc?gca?act?gtg?tcc?gct?tct?ggc?gac?aac 576

Thr?Thr?Pro?Ala?Ala?Ala?Ser?Ala?Thr?Val?Ser?Ala?Ser?Gly?Asp?Asn

180 185 190

gtt?cca?tac?gtc?acc?cca?ctg?gtg?cgc?aag?ctt?gct?gaa?aag?cac?ggc 624

Val?Pro?Tyr?Val?Thr?Pro?Leu?Val?Arg?Lys?Leu?Ala?Glu?Lys?His?Gly

195 200 205

gtt?gac?ttg?aac?acc?gtg?acc?ggt?acc?ggt?atc?ggt?ggc?cgt?atc?cgc 672

Val?Asp?Leu?Asn?Thr?Val?Thr?Gly?Thr?Gly?Ile?Gly?Gly?Arg?Ile?Arg

210 215 220

aag?cag?gat?gtt?ttg?gct?gct?gcg?aac?ggc?gag?gct?gca?cct?gct?gag 720

Lys?Gln?Asp?Val?Leu?Ala?Ala?Ala?Asn?Gly?Glu?Ala?Ala?Pro?Ala?Glu

225 230 235 240

gct?gct?gct?cct?gtt?tcc?gct?tgg?tcc?act?aag?tct?gtt?gac?cct?gag 768

Ala?Ala?Ala?Pro?Val?Ser?Ala?Trp?Ser?Thr?Lys?Ser?Val?Asp?Pro?Glu

245 250 255

aag?gct?aag?ctc?cgt?ggt?acc?act?cag?aag?gtc?aac?cgc?atc?cgt?gag 816

Lys?Ala?Lys?Leu?Arg?Gly?Thr?Thr?Gln?Lys?Val?Asn?Arg?Ile?Arg?Glu

260 265 270

atc?acc?gcg?atg?aag?acc?gtc?gag?gct?ctg?cag?att?tct?gct?cag?ctc 864

Ile?Thr?Ala?Met?Lys?Thr?Val?Glu?Ala?Leu?Gln?Ile?Ser?Ala?Gln?Leu

275 280 285

acc?cag?ctg?cac?gag?gtc?gat?atg?act?cgc?gtt?gct?gag?ctg?cgt?aag 912

Thr?Gln?Leu?His?Glu?Val?Asp?Met?Thr?Arg?Val?Ala?Glu?Leu?Arg?Lys

290 295 300

aag?aac?aag?ccc?gcg?ttc?atc?gag?aag?cac?ggt?gtg?aac?ctc?act?tac 960

Lys?Asn?Lys?Pro?Ala?Phe?Ile?Glu?Lys?His?Gly?Val?Asn?Leu?Thr?Tyr

305 310 315 320

ctg?cca?ttc?ttc?gtg?aag?gca?gtt?gtc?gag?gct?ttg?gtt?tcc?cat?cca 1008

Leu?Pro?Phe?Phe?Val?Lys?Ala?Val?Val?Glu?Ala?Leu?Val?Ser?His?Pro

325 330 335

aac?gtc?aac?gcg?tct?ttc?aac?gcg?aag?acc?aag?gag?atg?acc?tac?cac 1056

Asn?Val?Asn?Ala?Ser?Phe?Asn?Ala?Lys?Thr?Lys?Glu?Met?Thr?Tyr?His

340 345 350

tcc?tcc?gtt?aac?ctc?tcc?atc?gct?gtt?gat?acc?cca?gct?ggt?ctg?ttg 1104

Ser?Ser?Val?Asn?Leu?Ser?Ile?Ala?Val?Asp?Thr?Pro?Ala?Gly?Leu?Leu

355 360 365

acc?cca?gtc?att?cac?gat?gct?cag?gat?ctc?tcc?atc?cca?gag?atc?gca 1152

Thr?Pro?Val?Ile?His?Asp?Ala?Gln?Asp?Leu?Ser?Ile?Pro?Glu?Ile?Ala

370 375 380

aag?gca?att?gtt?gac?ctg?gct?gat?cgt?tca?cgc?aac?aac?aag?ctg?aag 1200

Lys?Ala?Ile?Val?Asp?Leu?Ala?Asp?Arg?Ser?Arg?Asn?Asn?Lys?Leu?Lys

385 390 395 400

cca?aac?gat?ctg?tcc?ggt?ggc?acc?ttc?acc?atc?acc?aac?att?ggt?tct 1248

Pro?Asn?Asp?Leu?Ser?Gly?Gly?Thr?Phe?Thr?Ile?Thr?Asn?Ile?Gly?Ser

405 410 415

gaa?ggc?gca?ctg?tct?gat?acc?cca?atc?ctg?gtt?cca?cca?cag?gct?ggc 1296

Glu?Gly?Ala?Leu?Ser?Asp?Thr?Pro?Ile?Leu?Val?Pro?Pro?Gln?Ala?Gly

420 425 430

atc?ttg?ggc?acc?ggc?gcg?atc?gtg?aag?cgt?cca?gtt?gtc?atc?acc?gag 1344

Ile?Leu?Gly?Thr?Gly?Ala?Ile?Val?Lys?Arg?Pro?Val?Val?Ile?Thr?Glu

435 440 445

gat?gga?att?gat?tcc?atc?gcg?atc?cgt?cag?atg?gtc?ttc?cta?cca?ctg 1392

Asp?Gly?Ile?Asp?Ser?Ile?Ala?Ile?Arg?Gln?Met?Val?Phe?Leu?Pro?Leu

450 455 460

acc?tac?gac?cac?cag?gtt?gta?gat?ggc?gca?gat?gct?ggt?cgc?ttc?ctg 1440

Thr?Tyr?Asp?His?Gln?Val?Val?Asp?Gly?Ala?Asp?Ala?Gly?Arg?Phe?Leu

465 470 475 480

acc?acc?atc?aag?gac?cgc?ctt?gag?acc?gct?aac?ttc?gaa?ggc?gat?ctg 1488

Thr?Thr?Ile?Lys?Asp?Arg?Leu?Glu?Thr?Ala?Asn?Phe?Glu?Gly?Asp?Leu

485 490 495

cag?ctc?taagatctct?gcaagttaaa?acc 1517

Gln?Leu

<210>564

<211>498

<212>PRT

＜213〉Corynebacterium glutamicum

<400>564

Ile?Leu?Ala?Asp?Glu?Asp?Asp?Thr?Val?Asp?Val?Gly?Ala?Val?Ile?Ala

1 5 10 15

Arg?Ile?Gly?Asp?Ala?Asn?Ala?Ala?Ala?Ala?Pro?Ala?Glu?Glu?Glu?Ala

20 25 30

Ala?Pro?Ala?Glu?Glu?Glu?Glu?Pro?Val?Lys?Glu?Glu?Pro?Lys?Lys?Glu

35 40 45

Ala?Ala?Pro?Glu?Ala?Pro?Ala?Ala?Thr?Gly?Ala?Ala?Thr?Asp?Val?Glu

50 55 60

Met?Pro?Glu?Leu?Gly?Glu?Ser?Val?Thr?Glu?Gly?Thr?Ile?Thr?Gln?Trp

65 70 75 80

Leu?Lys?Ala?Val?Gly?Asp?Thr?Val?Glu?Val?Asp?Glu?Pro?Leu?Leu?Glu

85 90 95

Val?Ser?Thr?Asp?Lys?Val?Asp?Thr?Glu?Ile?Pro?Ser?Pro?Val?Ala?Gly

100 105 110

Thr?Ile?Val?Glu?Ile?Leu?Ala?Asp?Glu?Asp?Asp?Thr?Val?Asp?Val?Gly

115 120 125

Ala?Val?Ile?Ala?Arg?Ile?Gly?Asp?Ala?Asn?Ala?Ala?Ala?Ala?Pro?Ala

130 135 140

Glu?Glu?Glu?Ala?Ala?Pro?Ala?Glu?Glu?Glu?Glu?Pro?Val?Lys?Glu?Glu

145 150 155 160

Pro?Lys?Lys?Glu?Glu?Pro?Lys?Lys?Glu?Glu?Pro?Lys?Lys?Glu?Ala?Ala

165 170 175

Thr?Thr?Pro?Ala?Ala?Ala?Ser?Ala?Thr?Val?Ser?Ala?Ser?Gly?Asp?Asn

180 185 190

Val?Pro?Tyr?Val?Thr?Pro?Leu?Val?Arg?Lys?Leu?Ala?Glu?Lys?His?Gly

195 200 205

Val?Asp?Leu?Asn?Thr?Val?Thr?Gly?Thr?Gly?Ile?Gly?Gly?Arg?Ile?Arg

210 215 220

Lys?Gln?Asp?Val?Leu?Ala?Ala?Ala?Asn?Gly?Glu?Ala?Ala?Pro?Ala?Glu

225 230 235 240

Ala?Ala?Ala?Pro?Val?Ser?Ala?Trp?Ser?Thr?Lys?Ser?Val?Asp?Pro?Glu

245 250 255

Lys?Ala?Lys?Leu?Arg?Gly?Thr?Thr?Gln?Lys?Val?Asn?Arg?Ile?Arg?Glu

260 265 270

Ile?Thr?Ala?Met?Lys?Thr?Val?Glu?Ala?Leu?Gln?Ile?Ser?Ala?Gln?Leu

275 280 285

Thr?Gln?Leu?His?Glu?Val?Asp?Met?Thr?Arg?Val?Ala?Glu?Leu?Arg?Lys

290 295 300

Lys?Asn?Lys?Pro?Ala?Phe?Ile?Glu?Lys?His?Gly?Val?Asn?Leu?Thr?Tyr

305 310 315 320

Leu?Pro?Phe?Phe?Val?Lys?Ala?Val?Val?Glu?Ala?Leu?Val?Ser?His?Pro

325 330 335

Asn?Val?Asn?Ala?Ser?Phe?Asn?Ala?Lys?Thr?Lys?Glu?Met?Thr?Tyr?His

340 345 350

Ser?Ser?Val?Asn?Leu?Ser?Ile?Ala?Val?Asp?Thr?Pro?Ala?Gly?Leu?Leu

355 360 365

Thr?Pro?Val?Ile?His?Asp?Ala?Gln?Asp?Leu?Ser?Ile?Pro?Glu?Ile?Ala

370 375 380

Lys?Ala?Ile?Val?Asp?Leu?Ala?Asp?Arg?Ser?Arg?Asn?Asn?Lys?Leu?Lys

385 390 395 400

Pro?Asn?Asp?Leu?Ser?Gly?Gly?Thr?Phe?Thr?Ile?Thr?Asn?Ile?Gly?Ser

405 410 415

Glu?Gly?Ala?Leu?Ser?Asp?Thr?Pro?Ile?Leu?Val?Pro?Pro?Gln?Ala?Gly

420 425 430

Ile?Leu?Gly?Thr?Gly?Ala?Ile?Val?Lys?Arg?Pro?Val?Val?Ile?Thr?Glu

435 440 445

Asp?Gly?Ile?Asp?Ser?Ile?Ala?Ile?Arg?Gln?Met?Val?Phe?Leu?Pro?Leu

450 455 460

Thr?Tyr?Asp?His?Gln?Val?Val?Asp?Gly?Ala?Asp?Ala?Gly?Arg?Phe?Leu

465 470 475 480

Thr?Thr?Ile?Lys?Asp?Arg?Leu?Glu?Thr?Ala?Asn?Phe?Glu?Gly?Asp?Leu

485 490 495

Gln?Leu

<210>565

<211>1005

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(982)

<223>RXA00782

<400>565

gggtatggat?gcagcggctg?atcacgctgc?ccatttggcc?aatcttgccc?agcacggcca?60

gttcgcaacc?gctaattagt?taaggagcac?ctgtttaatc?atg?tct?att?ttt?ctc 115

Met?Ser?Ile?Phe?Leu

1 5

aat?tca?gat?tcc?cgc?atc?atc?att?cag?ggc?att?acc?ggt?tcg?gaa?ggt 163

Asn?Ser?Asp?Ser?Arg?Ile?Ile?Ile?Gln?Gly?Ile?Thr?Gly?Ser?Glu?Gly

10 15 20

tca?gag?cat?gcg?cgt?cga?att?tta?gcc?tct?ggt?gcg?aag?ctc?gtg?ggt 211

Ser?Glu?His?Ala?Arg?Arg?Ile?Leu?Ala?Ser?Gly?Ala?Lys?Leu?Val?Gly

25 30 35

ggc?acc?aac?ccc?cgc?aaa?gct?ggg?caa?acc?att?ttg?atc?aat?gac?act 259

Gly?Thr?Asn?Pro?Arg?Lys?Ala?Gly?Gln?Thr?Ile?Leu?Ile?Asn?Asp?Thr

40 45 50

gag?ttg?cct?gta?ttt?ggc?act?gtt?aag?gaa?gca?atg?gag?gaa?acg?ggt 307

Glu?Leu?Pro?Val?Phe?Gly?Thr?Val?Lys?Glu?Ala?Met?Glu?Glu?Thr?Gly

55 60 65

gcg?gat?gtc?acc?gta?att?ttc?gtt?cct?cca?gcc?ttt?gcc?aaa?gct?gcg 355

Ala?Asp?Val?Thr?Val?Ile?Phe?Val?Pro?Pro?Ala?Phe?Ala?Lys?Ala?Ala

70 75 80 85

atc?att?gaa?gct?atc?gac?gct?cac?atc?cca?ctg?tgc?gtg?att?att?act 403

Ile?Ile?Glu?Ala?Ile?Asp?Ala?His?Ile?Pro?Leu?Cys?Val?Ile?Ile?Thr

90 95 100

gag?ggc?atc?cca?gtg?cgt?gac?gct?tct?gag?gcg?tgg?gct?tat?gcc?aag 451

Glu?Gly?Ile?Pro?Val?Arg?Asp?Ala?Ser?Glu?Ala?Trp?Ala?Tyr?Ala?Lys

105 110 115

aag?gtg?gga?cac?acc?cgc?atc?att?ggc?cct?aac?tgc?cca?ggc?att?att 499

Lys?Val?Gly?His?Thr?Arg?Ile?Ile?Gly?Pro?Asn?Cys?Pro?Gly?Ile?Ile

120 125 130

act?ccc?ggc?gaa?tct?ctt?gcg?gga?att?acg?ccg?gca?aac?att?gca?ggt 547

Thr?Pro?Gly?Glu?Ser?Leu?Ala?Gly?Ile?Thr?Pro?Ala?Asn?Ile?Ala?Gly

135 140 145

tcc?ggc?ccg?atc?ggg?ttg?atc?tca?aag?tcg?gga?aca?ctg?act?tat?cag 595

Ser?Gly?Pro?Ile?Gly?Leu?Ile?Ser?Lys?Ser?Gly?Thr?Leu?Thr?Tyr?Gln

150 155 160 165

atg?atg?tac?gaa?ctt?tca?gat?att?ggc?att?tct?acg?gcg?att?ggt?att 643

Met?Met?Tyr?Glu?Leu?Ser?Asp?Ile?Gly?Ile?Ser?Thr?Ala?Ile?Gly?Ile

170 175 180

ggc?ggt?gac?cca?atc?atc?ggt?aca?acc?cat?atc?gac?gct?ctg?gag?gcc 691

Gly?Gly?Asp?Pro?Ile?Ile?Gly?Thr?Thr?His?Ile?Asp?Ala?Leu?Glu?Ala

185 190 195

ttt?gaa?gct?gat?cct?gag?acc?aag?gca?atc?gtc?atg?atc?ggt?gag?atc 739

Phe?Glu?Ala?Asp?Pro?Glu?Thr?Lys?Ala?Ile?Val?Met?Ile?Gly?Glu?Ile

200 205 210

ggt?gga?gat?gca?gag?gaa?cgc?gct?gct?gac?ttc?att?tct?aag?cac?gtg 787

Gly?Gly?Asp?Ala?Glu?Glu?Arg?Ala?Ala?Asp?Phe?Ile?Ser?Lys?His?Val

215 220 225

aca?aaa?cca?gtt?gtg?ggt?tac?gtg?gca?ggc?ttt?acc?gcc?cct?gaa?gga 835

Thr?Lys?Pro?Val?Val?Gly?Tyr?Val?Ala?Gly?Phe?Thr?Ala?Pro?Glu?Gly

230 235 240 245

aag?acc?atg?ggg?cat?gct?ggc?gcc?atc?gtg?aca?ggt?tca?gaa?ggc?act 883

Lys?Thr?Met?Gly?His?Ala?Gly?Ala?Ile?Val?Thr?Gly?Ser?Glu?Gly?Thr

250 255 260

gcg?cga?gca?aag?aag?cat?gca?ttg?gag?gcc?gtg?ggt?gtt?cgc?gtg?gga 931

Ala?Arg?Ala?Lys?Lys?His?Ala?Leu?Glu?Ala?Val?Gly?Val?Arg?Val?Gly

265 270 275

aca?act?ccg?agt?gaa?acc?gcg?aag?ctt?atg?cgt?gag?gta?gtt?gca?gct 979

Thr?Thr?Pro?Ser?Glu?Thr?Ala?Lys?Leu?Met?Arg?Glu?Val?Val?Ala?Ala

280 285 290

ttg?taactaacag?gccacagatc?tta 1005

Leu

<210>566

<211>294

<212>PRT

＜213〉Corynebacterium glutamicum

<400>566

Met?Ser?Ile?Phe?Leu?Asn?Ser?Asp?Ser?Arg?Ile?Ile?Ile?Gln?Gly?Ile

1 5 10 15

Thr?Gly?Ser?Glu?Gly?Ser?Glu?His?Ala?Arg?Arg?Ile?Leu?Ala?Ser?Gly

20 25 30

Ala?Lys?Leu?Val?Gly?Gly?Thr?Asn?Pro?Arg?Lys?Ala?Gly?Gln?Thr?Ile

35 40 45

Leu?Ile?Asn?Asp?Thr?Glu?Leu?Pro?Val?Phe?Gly?Thr?Val?Lys?Glu?Ala

50 55 60

Met?Glu?Glu?Thr?Gly?Ala?Asp?Val?Thr?Val?Ile?Phe?Val?Pro?Pro?Ala

65 70 75 80

Phe?Ala?Lys?Ala?Ala?Ile?Ile?Glu?Ala?Ile?Asp?Ala?His?Ile?Pro?Leu

85 90 95

Cys?Val?Ile?Ile?Thr?Glu?Gly?Ile?Pro?Val?Arg?Asp?Ala?Ser?Glu?Ala

100 105 110

Trp?Ala?Tyr?Ala?Lys?Lys?Val?Gly?His?Thr?Arg?Ile?Ile?Gly?Pro?Asn

115 120 125

Cys?Pro?Gly?Ile?Ile?Thr?Pro?Gly?Glu?Ser?Leu?Ala?Gly?Ile?Thr?Pro

130 135 140

Ala?Asn?Ile?Ala?Gly?Ser?Gly?Pro?Ile?Gly?Leu?Ile?Ser?Lys?Ser?Gly

145 150 155 160

Thr?Leu?Thr?Tyr?Gln?Met?Met?Tyr?Glu?Leu?Ser?Asp?Ile?Gly?Ile?Ser

165 170 175

Thr?Ala?Ile?Gly?Ile?Gly?Gly?Asp?Pro?Ile?Ile?Gly?Thr?Thr?His?Ile

180 185 190

Asp?Ala?Leu?Glu?Ala?Phe?Glu?Ala?Asp?Pro?Glu?Thr?Lys?Ala?Ile?Val

195 200 205

Met?Ile?Gly?Glu?Ile?Gly?Gly?Asp?Ala?Glu?Glu?Arg?Ala?Ala?Asp?Phe

210 215 220

Ile?Ser?Lys?His?Val?Thr?Lys?Pro?Val?Val?Gly?Tyr?Val?Ala?Gly?Phe

225 230 235 240

Thr?Ala?Pro?Glu?Gly?Lys?Thr?Met?Gly?His?Ala?Gly?Ala?Ile?Val?Thr

245 250 255

Gly?Ser?Glu?Gly?Thr?Ala?Arg?Ala?Lys?Lys?His?Ala?Leu?Glu?Ala?Val

260 265 270

Gly?Val?Arg?Val?Gly?Thr?Thr?Pro?Ser?Glu?Thr?Ala?Lys?Leu?Met?Arg

275 280 285

Glu?Val?Val?Ala?Ala?Leu

290

<210>567

<211>1395

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1372)

<223>RXA00783

<400>567

aaagttccca?aggggtgggg?gctgagcacc?acggatccaa?ttttgttgca?atttgcaaag?60

tttacagtgt?tagacttcac?aatacgatca?tattggtgag?ttg?aaa?cac?tta?ctt 115

Leu?Lys?His?Leu?Leu

1 5

tta?cgg?gaa?gac?ttt?gtt?aaa?gac?gca?gaa?ggc?tct?aag?cat?ggg?ccg 163

Leu?Arg?Glu?Asp?Phe?Val?Lys?Asp?Ala?Glu?Gly?Ser?Lys?His?Gly?Pro

10 15 20

gaa?atg?gaa?ttg?gca?gtg?gat?ctt?ttt?gaa?tac?caa?gca?cgg?gac?ctc 211

Glu?Met?Glu?Leu?Ala?Val?Asp?Leu?Phe?Glu?Tyr?Gln?Ala?Arg?Asp?Leu

25 30 35

ttt?gaa?acc?cat?ggt?gtg?cca?gtg?ttg?aag?gga?att?gtg?gca?tca?aca 259

Phe?Glu?Thr?His?Gly?Val?Pro?Val?Leu?Lys?Gly?Ile?Val?Ala?Ser?Thr

40 45 50

cca?gag?gcg?gcg?agg?aaa?gcg?gct?gag?gaa?atc?ggc?gga?ctg?acc?gtc 307

Pro?Glu?Ala?Ala?Arg?Lys?Ala?Ala?Glu?Glu?Ile?Gly?Gly?Leu?Thr?Val

55 60 65

gtc?aag?gct?cag?gtc?aag?gtg?ggc?gga?cgt?ggc?aag?gcg?ggt?ggc?gtc 355

Val?Lys?Ala?Gln?Val?Lys?Val?Gly?Gly?Arg?Gly?Lys?Ala?Gly?Gly?Val

70 75 80 85

cgt?gtg?gca?ccg?acg?tcg?gct?cag?gct?ttt?gat?gct?gcg?gat?gcg?att 403

Arg?Val?Ala?Pro?Thr?Ser?Ala?Gln?Ala?Phe?Asp?Ala?Ala?Asp?Ala?Ile

90 95 100

ctc?ggc?atg?gat?atc?aaa?gga?cac?act?gtt?aat?cag?gtg?atg?gtg?gcg 451

Leu?Gly?Met?Asp?Ile?Lys?Gly?His?Thr?Val?Asn?Gln?Val?Met?Val?Ala

105 110 115

cag?ggc?gct?gac?att?gct?gag?gaa?tac?tat?ttc?tcc?att?ttg?ttg?gat 499

Gln?Gly?Ala?Asp?Ile?Ala?Glu?Glu?Tyr?Tyr?Phe?Ser?Ile?Leu?Leu?Asp

120 125 130

cgc?gcg?aat?cgt?tcg?tat?ctg?gct?atg?tgc?tct?gtt?gaa?ggt?ggc?atg 547

Arg?Ala?Asn?Arg?Ser?Tyr?Leu?Ala?Met?Cys?Ser?Val?Glu?Gly?Gly?Met

135 140 145

gag?atc?gag?atc?ctg?gcg?aag?gaa?aag?cct?gaa?gct?ttg?gca?aag?gtg 595

Glu?Ile?Glu?Ile?Leu?Ala?Lys?Glu?Lys?Pro?Glu?Ala?Leu?Ala?Lys?Val

150 155 160 165

gaa?gtg?gat?ccc?ctc?act?ggt?att?gat?gag?gac?aaa?gcg?cgg?gag?att 643

Glu?Val?Asp?Pro?Leu?Thr?Gly?Ile?Asp?Glu?Asp?Lys?Ala?Arg?Glu?Ile

170 175 180

gtc?act?gct?gct?ggc?ttt?gaa?act?gag?gtg?gca?gag?aaa?gtc?att?ccg 691

Val?Thr?Ala?Ala?Gly?Phe?Glu?Thr?Glu?Val?Ala?Glu?Lys?Val?Ile?Pro

185 190 195

gtg?ctg?atc?aag?atc?tgg?cag?gtg?tat?tac?gaa?gag?gaa?gca?aca?ctc 739

Val?Leu?Ile?Lys?Ile?Trp?Gln?Val?Tyr?Tyr?Glu?Glu?Glu?Ala?Thr?Leu

200 205 210

gtt?gag?gtg?aac?ccg?ttg?gtg?ctc?acg?gat?gac?ggc?gat?gtg?att?gcg 787

Val?Glu?Val?Asn?Pro?Leu?Val?Leu?Thr?Asp?Asp?Gly?Asp?Val?Ile?Ala

215 220 225

ctt?gat?ggc?aag?atc?acg?ctg?gat?gat?aac?gct?gat?ttc?cgc?cat?gat 835

Leu?Asp?Gly?Lys?Ile?Thr?Leu?Asp?Asp?Asn?Ala?Asp?Phe?Arg?His?Asp

230 235 240 245

aac?cgt?ggt?gcg?ttg?gct?gaa?tct?gcc?ggt?ggc?ttg?gac?att?ttg?gaa 883

Asn?Arg?Gly?Ala?Leu?Ala?Glu?Ser?Ala?Gly?Gly?Leu?Asp?Ile?Leu?Glu

250 255 260

ctg?aag?gcc?aag?aag?aat?gat?ctg?aac?tac?gtg?aaa?ctt?gat?ggc?tct 931

Leu?Lys?Ala?Lys?Lys?Asn?Asp?Leu?Asn?Tyr?Val?Lys?Leu?Asp?Gly?Ser

265 270 275

gtg?ggc?atc?att?ggc?aat?ggt?gca?ggt?ttg?gtg?atg?tcc?acg?ttg?gat 979

Val?Gly?Ile?Ile?Gly?Asn?Gly?Ala?Gly?Leu?Val?Met?Ser?Thr?Leu?Asp

280 285 290

atc?gtg?gct?gca?gct?ggt?gaa?cgc?cat?ggt?ggg?cag?cgc?ccc?gcg?aac 1027

Ile?Val?Ala?Ala?Ala?Gly?Glu?Arg?His?Gly?Gly?Gln?Arg?Pro?Ala?Asn

295 300 305

ttc?cta?gac?att?ggt?ggc?gga?gca?tca?gct?gaa?tcg?atg?gct?gct?ggt 1075

Phe?Leu?Asp?Ile?Gly?Gly?Gly?Ala?Ser?Ala?Glu?Ser?Met?Ala?Ala?Gly

310 315 320 325

ctc?gat?gtg?atc?ctt?ggg?gat?agc?cag?gta?cgc?agt?gtg?ttt?gtg?aat 1123

Leu?Asp?Val?Ile?Leu?Gly?Asp?Ser?Gln?Val?Arg?Ser?Val?Phe?Val?Asn

330 335 340

gtg?ttt?ggt?ggc?atc?acc?gcg?tgt?gat?gtg?gtg?gca?aag?gga?atc?gtt 1171

Val?Phe?Gly?Gly?Ile?Thr?Ala?Cys?Asp?Val?Val?Ala?Lys?Gly?Ile?Val

345 350 355

gga?gct?ttg?gat?gtg?ctc?ggc?gat?caa?gca?acg?aag?cct?ctt?gtg?gtg 1219

Gly?Ala?Leu?Asp?Val?Leu?Gly?Asp?Gln?Ala?Thr?Lys?Pro?Leu?Val?Val

360 365 370

cgc?ctt?gat?ggc?aac?aac?gtg?gtg?gaa?ggc?aga?cga?atc?ctc?gcg?gaa 1267

Arg?Leu?Asp?Gly?Asn?Asn?Val?Val?Glu?Gly?Arg?Arg?Ile?Leu?Ala?Glu

375 380 385

tat?aac?cac?cct?ttg?gtc?acc?gtt?gtg?gag?ggt?atg?gat?gca?gcg?gct 1315

Tyr?Asn?His?Pro?Leu?Val?Thr?Val?Val?Glu?Gly?Met?Asp?Ala?Ala?Ala

390 395 400 405

gat?cac?gct?gcc?cat?ttg?gcc?aat?ctt?gcc?cag?cac?ggc?cag?ttc?gca 1363

Asp?His?Ala?Ala?His?Leu?Ala?Asn?Leu?Ala?Gln?His?Gly?Gln?Phe?Ala

410 415 420

acc?gct?aat?tagttaagga?gcacctgttt?aat 1395

Thr?Ala?Asn

<210>568

<211>424

<212>PRT

＜213〉Corynebacterium glutamicum

<400>568

Leu?Lys?His?Leu?Leu?Leu?Arg?Glu?Asp?Phe?Val?Lys?Asp?Ala?Glu?Gly

1 5 10 15

Ser?Lys?His?Gly?Pro?Glu?Met?Glu?Leu?Ala?Val?Asp?Leu?Phe?Glu?Tyr

20 25 30

Gln?Ala?Arg?Asp?Leu?Phe?Glu?Thr?His?Gly?Val?Pro?Val?Leu?Lys?Gly

35 40 45

Ile?Val?Ala?Ser?Thr?Pro?Glu?Ala?Ala?Arg?Lys?Ala?Ala?Glu?Glu?Ile

50 55 60

Gly?Gly?Leu?Thr?Val?Val?Lys?Ala?Gln?Val?Lys?Val?Gly?Gly?Arg?Gly

65 70 75 80

Lys?Ala?Gly?Gly?Val?Arg?Val?Ala?Pro?Thr?Ser?Ala?Gln?Ala?Phe?Asp

85 90 95

Ala?Ala?Asp?Ala?Ile?Leu?Gly?Met?Asp?Ile?Lys?Gly?His?Thr?Val?Asn

100 105 1l0

Gln?Val?Met?Val?Ala?Gln?Gly?Ala?Asp?Ile?Ala?Glu?Glu?Tyr?Tyr?Phe

115 120 125

Ser?Ile?Leu?Leu?Asp?Arg?Ala?Asn?Arg?Ser?Tyr?Leu?Ala?Met?Cys?Ser

130 135 140

Val?Glu?Gly?Gly?Met?Glu?Ile?Glu?Ile?Leu?Ala?Lys?Glu?Lys?Pro?Glu

145 150 155 160

Ala?Leu?Ala?Lys?Val?Glu?Val?Asp?Pro?Leu?Thr?Gly?Ile?Asp?Glu?Asp

165 170 175

Lys?Ala?Arg?Glu?Ile?Val?Thr?Ala?Ala?Gly?Phe?Glu?Thr?Glu?Val?Ala

180 185 190

Glu?Lys?Val?Ile?Pro?Val?Leu?Ile?Lys?Ile?Trp?Gln?Val?Tyr?Tyr?Glu

195 200 205

Glu?Glu?Ala?Thr?Leu?Val?Glu?Val?Asn?Pro?Leu?Val?Leu?Thr?Asp?Asp

210 215 220

Gly?Asp?Val?Ile?Ala?Leu?Asp?Gly?Lys?Ile?Thr?Leu?Asp?Asp?Asn?Ala

225 230 235 240

Asp?Phe?Arg?His?Asp?Asn?Arg?Gly?Ala?Leu?Ala?Glu?Ser?Ala?Gly?Gly

245 250 255

Leu?Asp?Ile?Leu?Glu?Leu?Lys?Ala?Lys?Lys?Asn?Asp?Leu?Asn?Tyr?Val

260 265 270

Lys?Leu?Asp?Gly?Ser?Val?Gly?Ile?Ile?Gly?Asn?Gly?Ala?Gly?Leu?Val

275 280 285

Met?Ser?Thr?Leu?Asp?Ile?Val?Ala?Ala?Ala?Gly?Glu?Arg?His?Gly?Gly

290 295 300

Gln?Arg?Pro?Ala?Asn?Phe?Leu?Asp?Ile?Gly?Gly?Gly?Ala?Ser?Ala?Glu

305 310 315 320

Ser?Met?Ala?Ala?Gly?Leu?Asp?Val?Ile?Leu?Gly?Asp?Ser?Gln?Val?Arg

325 330 335

Ser?Val?Phe?Val?Asn?Val?Phe?Gly?Gly?Ile?Thr?Ala?Cys?Asp?Val?Val

340 345 350

Ala?Lys?Gly?Ile?Val?Gly?Ala?Leu?Asp?Val?Leu?Gly?Asp?Gln?Ala?Thr

355 360 365

Lys?Pro?Leu?Val?Val?Arg?Leu?Asp?Gly?Asn?Asn?Val?Val?Glu?Gly?Arg

370 375 380

Arg?Ile?Leu?Ala?Glu?Tyr?Asn?His?Pro?Leu?Val?Thr?Val?Val?Glu?Gly

385 390 395 400

Met?Asp?Ala?Ala?Ala?Asp?His?Ala?Ala?His?Leu?Ala?Asn?Leu?Ala?Gln

405 410 415

His?Gly?Gln?Phe?Ala?Thr?Ala?Asn

420

<210>569

<211>1623

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1600)

<223>RXN01695

<400>569

tatggccaac?acttgcattc?gggtgctggc?gatcatttat?gagatgacgc?cttgtgttgg?60

tgttcggcag?agaactcgcg?gagataaaag?gaagttgaac?atg?tca?gat?tcc?ccg 115

Met?Ser?Asp?Ser?Pro

1 5

aag?aac?gca?ccg?agg?att?acc?gat?gag?gca?gat?gta?gtt?ctc?att?ggt 163

Lys?Asn?Ala?Pro?Arg?Ile?Thr?Asp?Glu?Ala?Asp?Val?Val?Leu?Ile?Gly

10 15 20

gcc?ggt?atc?atg?agc?tcc?acg?ctg?ggt?gca?atg?ctg?cgt?cag?ctg?gag 211

Ala?Gly?Ile?Met?Ser?Ser?Thr?Leu?Gly?Ala?Met?Leu?Arg?Gln?Leu?Glu

25 30 35

cca?agc?tgg?act?cag?atc?gtc?ttc?gag?cgt?ttg?gat?gga?ccg?gca?caa 259

Pro?Ser?Trp?Thr?Gln?Ile?Val?Phe?Glu?Arg?Leu?Asp?Gly?Pro?Ala?Gln

40 45 50

gag?tcg?tcc?tcc?ccg?tgg?aac?aat?gca?gga?acc?ggc?cac?tct?gct?cta 307

Glu?Ser?Ser?Ser?Pro?Trp?Asn?Asn?Ala?Gly?Thr?Gly?His?Ser?Ala?Leu

55 60 65

tgc?gag?ctg?aac?tac?acc?cca?gag?gtt?aag?ggc?aag?gtt?gaa?att?gcc 355

Cys?Glu?Leu?Asn?Tyr?Thr?Pro?Glu?Val?Lys?Gly?Lys?Val?Glu?Ile?Ala

70 75 80 85

aag?gct?gta?gga?atc?aac?gag?aag?ttc?cag?gtt?tcc?cgt?cag?ttc?tgg 403

Lys?Ala?Val?Gly?Ile?Asn?Glu?Lys?Phe?Gln?Val?Ser?Arg?Gln?Phe?Trp

90 95 100

tct?cac?ctc?gtt?gaa?gag?gga?gtg?ctg?tct?gat?cct?aag?gaa?ttc?atc 451

Ser?His?Leu?Val?Glu?Glu?Gly?Val?Leu?Ser?Asp?Pro?Lys?Glu?Phe?Ile

105 110 115

aac?cct?gtt?cct?cac?gta?tct?ttc?ggc?cag?ggc?gca?gat?cag?gtt?gca 499

Asn?Pro?Val?Pro?His?Val?Ser?Phe?Gly?Gln?Gly?Ala?Asp?Gln?Val?Ala

120 125 130

tac?atc?aag?gct?cgc?tac?gaa?gct?ttg?aag?gat?cac?cca?ctc?ttc?cag 547

Tyr?Ile?Lys?Ala?Arg?Tyr?Glu?Ala?Leu?Lys?Asp?His?Pro?Leu?Phe?Gln

135 140 145

ggc?atg?acc?tac?gct?gac?gat?gaa?gct?acc?ttc?acc?gag?aag?ctg?cct 595

Gly?Met?Thr?Tyr?Ala?Asp?Asp?Glu?Ala?Thr?Phe?Thr?Glu?Lys?Leu?Pro

150 155 160 165

ttg?atg?gca?aag?ggc?cgt?gac?ttc?tct?gat?cca?gta?gca?atc?tct?tgg 643

Leu?Met?Ala?Lys?Gly?Arg?Asp?Phe?Ser?Asp?Pro?Val?Ala?Ile?Ser?Trp

170 175 180

atc?gat?gaa?ggc?acc?gac?atc?aac?tac?ggt?gct?cag?acc?aag?cag?tac 691

Ile?Asp?Glu?Gly?Thr?Asp?Ile?Asn?Tyr?Gly?Ala?Gln?Thr?Lys?Gln?Tyr

185 190 195

ctg?gat?gca?gct?gaa?gtt?gaa?ggc?act?gaa?atc?cgc?tat?ggc?cac?gaa 739

Leu?Asp?Ala?Ala?Glu?Val?Glu?Gly?Thr?Glu?Ile?Arg?Tyr?Gly?His?Glu

200 205 210

gtc?aag?agc?atc?aag?gct?gat?ggc?gca?aag?tgg?atc?gtg?acc?gtc?aag 787

Val?Lys?Ser?Ile?Lys?Ala?Asp?Gly?Ala?Lys?Trp?Ile?Val?Thr?Val?Lys

215 220 225

aac?gta?cac?act?ggc?gac?acc?aag?acc?atc?aag?gca?aac?ttc?gtg?ttc 835

Asn?Val?His?Thr?Gly?Asp?Thr?Lys?Thr?Ile?Lys?Ala?Asn?Phe?Val?Phe

230 235 240 245

gtc?ggc?gca?ggc?gga?tac?gca?ctg?gat?ctg?ctt?cgc?agc?gca?ggc?atc 883

Val?Gly?Ala?Gly?Gly?Tyr?Ala?Leu?Asp?Leu?Leu?Arg?Ser?Ala?Gly?Ile

250 255 260

cca?cag?gtc?aag?ggc?ttc?gct?gga?ttc?cca?gta?tcc?ggc?ctg?tgg?ctt 931

Pro?Gln?Val?Lys?Gly?Phe?Ala?Gly?Phe?Pro?Val?Ser?Gly?Leu?Trp?Leu

265 270 275

cgt?tgc?acc?aac?gag?gaa?ctg?atc?gag?cag?cac?gca?gcc?aag?gta?tat 979

Arg?Cys?Thr?Asn?Glu?Glu?Leu?Ile?Glu?Gln?His?Ala?Ala?Lys?Val?Tyr

280 285 290

ggc?aag?gca?tct?gtt?ggc?gct?cct?cca?atg?tct?gtt?cct?cac?ctt?gac 1027

Gly?Lys?Ala?Ser?Val?Gly?Ala?Pro?Pro?Met?Ser?Val?Pro?His?Leu?Asp

295 300 305

acc?cgc?gtt?atc?gag?ggt?gaa?aag?ggt?ctg?ctc?ttt?gga?cct?tac?ggt 1075

Thr?Arg?Val?Ile?Glu?Gly?Glu?Lys?Gly?Leu?Leu?Phe?Gly?Pro?Tyr?Gly

310 315 320 325

ggc?tgg?acc?cct?aag?ttc?ttg?aag?gaa?ggc?tcc?tac?ctg?gac?ctg?ttc 1123

Gly?Trp?Thr?Pro?Lys?Phe?Leu?Lys?Glu?Gly?Ser?Tyr?Leu?Asp?Leu?Phe

330 335 340

aag?tcc?atc?cgc?cca?gac?aac?att?cct?tcc?tac?ctt?ggc?gtt?gct?gct 1171

Lys?Ser?Ile?Arg?Pro?Asp?Asn?Ile?Pro?Ser?Tyr?Leu?Gly?Val?Ala?Ala

345 350 355

cag?gaa?ttt?gat?ctg?acc?aag?tac?ctt?gtc?act?gaa?gtt?ctc?aag?gac 1219

Gln?Glu?Phe?Asp?Leu?Thr?Lys?Tyr?Leu?Val?Thr?Glu?Val?Leu?Lys?Asp

360 365 370

cag?gac?aag?cgt?atg?gat?gct?ctt?cgc?gag?tac?atg?cca?gag?gca?caa 1267

Gln?Asp?Lys?Arg?Met?Asp?Ala?Leu?Arg?Glu?Tyr?Met?Pro?Glu?Ala?Gln

375 380 385

aac?ggc?gat?tgg?gag?acc?atc?gtt?gcc?gga?cag?cgt?gtt?cag?gtt?att 1315

Asn?Gly?Asp?Trp?Glu?Thr?Ile?Val?Ala?Gly?Gln?Arg?Val?Gln?Val?Ile

390 395 400 405

aag?cct?gca?gga?ttc?cct?aag?ttc?ggt?tcc?ctg?gaa?ttc?ggc?acc?acc 1363

Lys?Pro?Ala?Gly?Phe?Pro?Lys?Phe?Gly?Ser?Leu?Glu?Phe?Gly?Thr?Thr

410 415 420

ttg?atc?aac?aac?tcc?gaa?ggc?acc?atc?gcc?gga?ttg?ctc?ggt?gct?tcc 1411

Leu?Ile?Asn?Asn?Ser?Glu?Gly?Thr?Ile?Ala?Gly?Leu?Leu?Gly?Ala?Ser

425 430 435

cct?gga?gca?tcc?atc?gca?cct?tcc?gca?atg?atc?gag?ctg?ctt?gag?cgt 1459

Pro?Gly?Ala?Ser?Ile?Ala?Pro?Ser?Ala?Met?Ile?Glu?Leu?Leu?Glu?Arg

440 445 450

tgc?ttc?ggt?gac?cgc?atg?atc?gag?tgg?ggc?gac?aag?ctg?aag?gac?atg 1507

Cys?Phe?Gly?Asp?Arg?Met?Ile?Glu?Trp?Gly?Asp?Lys?Leu?Lys?Asp?Met

455 460 465

atc?cct?tcc?tac?ggc?aag?aag?ctt?gct?tcc?gag?cca?gca?ctg?ttt?gag 1555

Ile?Pro?Ser?Tyr?Gly?Lys?Lys?Leu?Ala?Ser?Glu?Pro?Ala?Leu?Phe?Glu

470 475 480 485

cag?cag?tgg?gca?cgc?acc?cag?aag?acc?ctg?aag?ctt?gag?gaa?gcc 1600

Gln?Gln?Trp?Ala?Arg?Thr?Gln?Lys?Thr?Leu?Lys?Leu?Glu?Glu?Ala

490 495 500

taaatcttct?aactgctttc?ttt 1623

<210>570

<211>500

<212>PRT

＜213〉Corynebacterium glutamicum

<400>570

Met?Ser?Asp?Ser?Pro?Lys?Asn?Ala?Pro?Arg?Ile?Thr?Asp?Glu?Ala?Asp

1 5 10 15

Val?Val?Leu?Ile?Gly?Ala?Gly?Ile?Met?Ser?Ser?Thr?Leu?Gly?Ala?Met

20 25 30

Leu?Arg?Gln?Leu?Glu?Pro?Ser?Trp?Thr?Gln?Ile?Val?Phe?Glu?Arg?Leu

35 40 45

Asp?Gly?Pro?Ala?Gln?Glu?Ser?Ser?Ser?Pro?Trp?Asn?Asn?Ala?Gly?Thr

50 55 60

Gly?His?Ser?Ala?Leu?Cys?Glu?Leu?Asn?Tyr?Thr?Pro?Glu?Val?Lys?Gly

65 70 75 80

Lys?Val?Glu?Ile?Ala?Lys?Ala?Val?Gly?Ile?Asn?Glu?Lys?Phe?Gln?Val

85 90 95

Ser?Arg?Gln?Phe?Trp?Ser?His?Leu?Val?Glu?Glu?Gly?Val?Leu?Ser?Asp

100 105 110

Pro?Lys?Glu?Phe?Ile?Asn?Pro?Val?Pro?His?Val?Ser?Phe?Gly?Gln?Gly

115 120 125

Ala?Asp?Gln?Val?Ala?Tyr?Ile?Lys?Ala?Arg?Tyr?Glu?Ala?Leu?Lys?Asp

130 135 140

His?Pro?Leu?Phe?Gln?Gly?Met?Thr?Tyr?Ala?Asp?Asp?Glu?Ala?Thr?Phe

145 150 155 160

Thr?Glu?Lys?Leu?Pro?Leu?Met?Ala?Lys?Gly?Arg?Asp?Phe?Ser?Asp?Pro

165 170 175

Val?Ala?Ile?Ser?Trp?Ile?Asp?Glu?Gly?Thr?Asp?Ile?Asn?Tyr?Gly?Ala

180 185 190

Gln?Thr?Lys?Gln?Tyr?Leu?Asp?Ala?Ala?Glu?Val?Glu?Gly?Thr?Glu?Ile

195 200 205

Arg?Tyr?Gly?His?Glu?Val?Lys?Ser?Ile?Lys?Ala?Asp?Gly?Ala?Lys?Trp

210 215 220

Ile?Val?Thr?Val?Lys?Asn?Val?His?Thr?Gly?Asp?Thr?Lys?Thr?Ile?Lys

225 230 235 240

Ala?Asn?Phe?Val?Phe?Val?Gly?Ala?Gly?Gly?Tyr?Ala?Leu?Asp?Leu?Leu

245 250 255

Arg?Ser?Ala?Gly?Ile?Pro?Gln?Val?Lys?Gly?Phe?Ala?Gly?Phe?Pro?Val

260 265 270

Ser?Gly?Leu?Trp?Leu?Arg?Cys?Thr?Asn?Glu?Glu?Leu?Ile?Glu?Gln?His

275 280 285

Ala?Ala?Lys?Val?Tyr?Gly?Lys?Ala?Ser?Val?Gly?Ala?Pro?Pro?Met?Ser

290 295 300

Val?Pro?His?Leu?Asp?Thr?Arg?Val?Ile?Glu?Gly?Glu?Lys?Gly?Leu?Leu

305 310 315 320

Phe?Gly?Pro?Tyr?Gly?Gly?Trp?Thr?Pro?Lys?Phe?Leu?Lys?Glu?Gly?Ser

325 330 335

Tyr?Leu?Asp?Leu?Phe?Lys?Ser?Ile?Arg?Pro?Asp?Asn?Ile?Pro?Ser?Tyr

340 345 350

Leu?Gly?Val?Ala?Ala?Gln?Glu?Phe?Asp?Leu?Thr?Lys?Tyr?Leu?Val?Thr

355 360 365

Glu?Val?Leu?Lys?Asp?Gln?Asp?Lys?Arg?Met?Asp?Ala?Leu?Arg?Glu?Tyr

370 375 380

Met?Pro?Glu?Ala?Gln?Asn?Gly?Asp?Trp?Glu?Thr?Ile?Val?Ala?Gly?Gln

385 390 395 400

Arg?Val?Gln?Val?Ile?Lys?Pro?Ala?Gly?Phe?Pro?Lys?Phe?Gly?Ser?Leu

405 410 415

Glu?Phe?Gly?Thr?Thr?Leu?Ile?Asn?Asn?Ser?Glu?Gly?Thr?Ile?Ala?Gly

420 425 430

Leu?Leu?Gly?Ala?Ser?Pro?Gly?Ala?Ser?Ile?Ala?Pro?Ser?Ala?Met?Ile

435 440 445

Glu?Leu?Leu?Glu?Arg?Cys?Phe?Gly?Asp?Arg?Met?Ile?Glu?Trp?Gly?Asp

450 455 460

Lys?Leu?Lys?Asp?Met?Ile?Pro?Ser?Tyr?Gly?Lys?Lys?Leu?Ala?Ser?Glu

465 470 475 480

Pro?Ala?Leu?Phe?Glu?Gln?Gln?Trp?Ala?Arg?Thr?Gln?Lys?Thr?Leu?Lys

485 490 495

Leu?Glu?Glu?Ala

500

<210>571

<211>1039

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1039)

<223>FRXA01615

<400>571

tatggccaac?acttgcattc?gggtgctggc?gatcatttat?gagatgacgc?cttgtgttgg?60

tgttcggcag?agaactcgcg?gagataaaag?gaagttgaac?atg?tca?gat?tcc?ccg 115

Met?Ser?Asp?Ser?Pro

1 5

aag?aac?gca?ccg?agg?att?acc?gat?gag?gca?gat?gta?gtt?ctc?att?ggt 163

Lys?Asn?Ala?Pro?Arg?Ile?Thr?Asp?Glu?Ala?Asp?Val?Val?Leu?Ile?Gly

10 15 20

gcc?ggt?atc?atg?agc?tcc?acg?ctg?ggt?gca?atg?ctg?cgt?cag?ctg?gag 211

Ala?Gly?Ile?Met?Ser?Ser?Thr?Leu?Gly?Ala?Met?Leu?Arg?Gln?Leu?Glu

25 30 35

cca?agc?tgg?act?cag?atc?gtc?ttc?gag?cgt?ttg?gat?gga?ccg?gca?caa 259

Pro?Ser?Trp?Thr?Gln?Ile?Val?Phe?Glu?Arg?Leu?Asp?Gly?Pro?Ala?Gln

40 45 50

gag?tcg?tcc?tcc?ccg?tgg?aac?aat?gca?gga?acc?ggc?cac?tct?gct?cta 307

Glu?Ser?Ser?Ser?Pro?Trp?Asn?Asn?Ala?Gly?Thr?Gly?His?Ser?Ala?Leu

55 60 65

tgc?gag?ctg?aac?tac?acc?cca?gag?gtt?aag?ggc?aag?gtt?gaa?att?gcc 355

Cys?Glu?Leu?Asn?Tyr?Thr?Pro?Glu?Val?Lys?Gly?Lys?Val?Glu?Ile?Ala

70 75 80 85

aag?gct?gta?gga?atc?aac?gag?aag?ttc?cag?gtt?tcc?cgt?cag?ttc?tgg 403

Lys?Ala?Val?Gly?Ile?Asn?Glu?Lys?Phe?Gln?Val?Ser?Arg?Gln?Phe?Trp

90 95 100

tct?cac?ctc?gtt?gaa?gag?gga?gtg?ctg?tct?gat?cct?aag?gaa?ttc?atc 451

Ser?His?Leu?Val?Glu?Glu?Gly?Val?Leu?Ser?Asp?Pro?Lys?Glu?Phe?Ile

105 110 115

aac?cct?gtt?cct?cac?gta?tct?ttc?ggc?cag?ggc?gca?gat?cag?gtt?gca 499

Asn?Pro?Val?Pro?His?Val?Ser?Phe?Gly?Gln?Gly?Ala?Asp?Gln?Val?Ala

120 125 130

tac?atc?aag?gct?cgc?tac?gaa?gct?ttg?aag?gat?cac?cca?ctc?ttc?cag 547

Tyr?Ile?Lys?Ala?Arg?Tyr?Glu?Ala?Leu?Lys?Asp?His?Pro?Leu?Phe?Gln

135 140 145

ggc?atg?acc?tac?gct?gac?gat?gaa?gct?acc?ttc?acc?gag?aag?ctg?cct 595

Gly?Met?Thr?Tyr?Ala?Asp?Asp?Glu?Ala?Thr?Phe?Thr?Glu?Lys?Leu?Pro

150 155 160 165

ttg?atg?gca?aag?ggc?cgt?gac?ttc?tct?gat?cca?gta?gca?atc?tct?tgg 643

Leu?Met?Ala?Lys?Gly?Arg?Asp?Phe?Ser?Asp?Pro?Val?Ala?Ile?Ser?Trp

170 175 180

atc?gat?gaa?ggc?acc?gac?atc?aac?tac?ggt?gct?cag?acc?aag?cag?tac 691

Ile?Asp?Glu?Gly?Thr?Asp?Ile?Asn?Tyr?Gly?Ala?Gln?Thr?Lys?Gln?Tyr

185 190 195

ctg?gat?gca?gct?gaa?gtt?gaa?ggc?act?gaa?atc?cgc?tat?ggc?cac?gaa 739

Leu?Asp?Ala?Ala?Glu?Val?Glu?Gly?Thr?Glu?Ile?Arg?Tyr?Gly?His?Glu

200 205 210

gtc?aag?agc?atc?aag?gct?gat?ggc?gca?aag?tgg?atc?gtg?acc?gtc?aag 787

Val?Lys?Ser?Ile?Lys?Ala?Asp?Gly?Ala?Lys?Trp?Ile?Val?Thr?Val?Lys

215 220 225

aac?gta?cac?act?ggc?gac?acc?aag?acc?atc?aag?gca?aac?ttc?gtg?ttc 835

Asn?Val?His?Thr?Gly?Asp?Thr?Lys?Thr?Ile?Lys?Ala?Asn?Phe?Val?Phe

230 235 240 245

gtc?ggc?gca?ggc?gga?tac?gca?ctg?gat?ctg?ctt?cgc?agc?gca?ggc?atc 883

Val?Gly?Ala?Gly?Gly?Tyr?Ala?Leu?Asp?Leu?Leu?Arg?Ser?Ala?Gly?Ile

250 255 260

cca?cag?gtc?aag?ggc?ttc?gct?gga?ttc?cca?gta?tcc?ggc?ctg?tgg?ctt 931

Pro?Gln?Val?Lys?Gly?Phe?Ala?Gly?Phe?Pro?Val?Ser?Gly?Leu?Trp?Leu

265 270 275

cgt?tgc?acc?aac?gag?gaa?ctg?atc?gag?cag?cac?gca?gcc?aag?gta?tat 979

Arg?Cys?Thr?Asn?Glu?Glu?Leu?Ile?Glu?Gln?His?Ala?Ala?Lys?Val?Tyr

280 285 290

ggc?aag?gca?tct?gtt?ggc?gct?cct?cca?atg?tct?gtt?cct?cac?ctt?gac 1027

Gly?Lys?Ala?Ser?Val?Gly?Ala?Pro?Pro?Met?Ser?Val?Pro?His?Leu?Asp

295 300 305

acc?cgc?gtt?atc 1039

Thr?Arg?Val?Ile

310

<210>572

<211>313

<212>PRT

＜213〉Corynebacterium glutamicum

<400>572

Met?Ser?Asp?Ser?Pro?Lys?Asn?Ala?Pro?Arg?Ile?Thr?Asp?Glu?Ala?Asp

1 5 10 15

Val?Val?Leu?Ile?Gly?Ala?Gly?Ile?Met?Ser?Ser?Thr?Leu?Gly?Ala?Met

20 25 30

Leu?Arg?Gln?Leu?Glu?Pro?Ser?Trp?Thr?Gln?Ile?Val?Phe?Glu?Arg?Leu

35 40 45

Asp?Gly?Pro?Ala?Gln?Glu?Ser?Ser?Ser?Pro?Trp?Asn?Asn?Ala?Gly?Thr

50 55 60

Gly?His?Ser?Ala?Leu?Cys?Glu?Leu?Asn?Tyr?Thr?Pro?Glu?Val?Lys?Gly

65 70 75 80

Lys?Val?Glu?Ile?Ala?Lys?Ala?Val?Gly?Ile?Asn?Glu?Lys?Phe?Gln?Val

85 90 95

Ser?Arg?Gln?Phe?Trp?Ser?His?Leu?Val?Glu?Glu?Gly?Val?Leu?Ser?Asp

100 105 110

Pro?Lys?Glu?Phe?Ile?Asn?Pro?Val?Pro?His?Val?Ser?Phe?Gly?Gln?Gly

115 120 125

Ala?Asp?Gln?Val?Ala?Tyr?Ile?Lys?Ala?Arg?Tyr?Glu?Ala?Leu?Lys?Asp

130 135 140

His?Pro?Leu?Phe?Gln?Gly?Met?Thr?Tyr?Ala?Asp?Asp?Glu?Ala?Thr?Phe

145 150 155 160

Thr?Glu?Lys?Leu?Pro?Leu?Met?Ala?Lys?Gly?Arg?Asp?Phe?Ser?Asp?Pro

165 170 175

Val?Ala?Ile?Ser?Trp?Ile?Asp?Glu?Gly?Thr?Asp?Ile?Asn?Tyr?Gly?Ala

180 185 190

Gln?Thr?Lys?Gln?Tyr?Leu?Asp?Ala?Ala?Glu?Val?Glu?Gly?Thr?Glu?Ile

195 200 205

Arg?Tyr?Gly?His?Glu?Val?Lys?Ser?Ile?Lys?Ala?Asp?Gly?Ala?Lys?Trp

210 215 220

Ile?Val?Thr?Val?Lys?Asn?Val?His?Thr?Gly?Asp?Thr?Lys?Thr?Ile?Lys

225 230 235 240

Ala?Asn?Phe?Val?Phe?Val?Gly?Ala?Gly?Gly?Tyr?Ala?Leu?Asp?Leu?Leu

245 250 255

Arg?Ser?Ala?Gly?Ile?Pro?Gln?Val?Lys?Gly?Phe?Ala?Gly?Phe?Pro?Val

260 265 270

Ser?Gly?Leu?Trp?Leu?Arg?Cys?Thr?Asn?Glu?Glu?Leu?Ile?Glu?Gln?His

275 280 285

Ala?Ala?Lys?Val?Tyr?Gly?Lys?Ala?Ser?Val?Gly?Ala?Pro?Pro?Met?Ser

290 295 300

Val?Pro?His?Leu?Asp?Thr?Arg?Val?Ile

305 310

<210>573

<211>233

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(210)

<223>FRXA01695

<400>573

gcc?gga?ttg?ctc?ggt?gct?tcc?cct?gga?gca?tcc?atc?gca?cct?tcc?gca 48

Ala?Gly?Leu?Leu?Gly?Ala?Ser?Pro?Gly?Ala?Ser?Ile?Ala?Pro?Ser?Ala

1 5 10 15

atg?atc?gag?ctg?ctt?gag?cgt?tgc?ttc?ggt?gac?cgc?atg?atc?gag?tgg 96

Met?Ile?Glu?Leu?Leu?Glu?Arg?Cys?Phe?Gly?Asp?Arg?Met?Ile?Glu?Trp

20 25 30

ggc?gac?aag?ctg?aag?gac?atg?atc?cct?tcc?tac?ggc?aag?aag?ctt?gct 144

Gly?Asp?Lys?Leu?Lys?Asp?Met?Ile?Pro?Ser?Tyr?Gly?Lys?Lys?Leu?Ala

35 40 45

tcc?gag?cca?gca?ctg?ttt?gag?cag?cag?tgg?gca?cgc?acc?cag?aag?acc 192

Ser?Glu?Pro?Ala?Leu?Phe?Glu?Gln?Gln?Trp?Ala?Arg?Thr?Gln?Lys?Thr

50 55 60

ctg?aag?ctt?gag?gaa?gcc?taaatcttct?aactgctttc?ttt 233

Leu?Lys?Leu?Glu?Glu?Ala

65 70

<210>574

<211>70

<212>PRT

＜213〉Corynebacterium glutamicum

<400>574

Ala?Gly?Leu?Leu?Gly?Ala?Ser?Pro?Gly?Ala?Ser?Ile?Ala?Pro?Ser?Ala

1 5 10 15

Met?Ile?Glu?Leu?Leu?Glu?Arg?Cys?Phe?Gly?Asp?Arg?Met?Ile?Glu?Trp

20 25 30

Gly?Asp?Lys?Leu?Lys?Asp?Met?Ile?Pro?Ser?Tyr?Gly?Lys?Lys?Leu?Ala

35 40 45

Ser?Glu?Pro?Ala?Leu?Phe?Glu?Gln?Gln?Trp?Ala?Arg?Thr?Gln?Lys?Thr

50 55 60

Leu?Lys?Leu?Glu?Glu?Ala

65 70

<210>575

<211>1063

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1063)

<223>RXA00290

<400>575

agctacagat?ttagctagtg?tttttgttcc?agaaccctaa?atgaggttct?acccttaaca?60

gagcttcccg?caaaaacacc?gattaacaag?gctaaatgat?atg?acc?atc?gac?ctg 115

Met?Thr?Ile?Asp?Leu

1 5

cag?cgt?tcc?acc?caa?aac?ctc?acc?cat?gag?gaa?atc?ttc?gag?gca?cac 163

Gln?Arg?Ser?Thr?Gln?Asn?Leu?Thr?His?Glu?Glu?Ile?Phe?Glu?Ala?His

10 15 20

gag?ggc?gga?aag?ctc?tcc?att?agt?tcc?act?cgt?ccg?ctc?cgc?gac?atg 211

Glu?Gly?Gly?Lys?Leu?Ser?Ile?Ser?Ser?Thr?Arg?Pro?Leu?Arg?Asp?Met

25 30 35

cgc?gat?ctt?tcc?ctt?gct?tac?acc?cct?ggt?gtt?gct?cag?gtt?tgt?gaa 259

Arg?Asp?Leu?Ser?Leu?Ala?Tyr?Thr?Pro?Gly?Val?Ala?Gln?Val?Cys?Glu

40 45 50

gca?atc?aag?gaa?gat?cca?gag?gtt?gcg?cgc?acc?cac?acg?ggc?att?gga 307

Ala?Ile?Lys?Glu?Asp?Pro?Glu?Val?Ala?Arg?Thr?His?Thr?Gly?Ile?Gly

55 60 65

aac?acc?gtc?gcg?gtt?att?tcc?gac?ggc?acc?gct?gtt?ctt?ggc?ctt?ggc 355

Asn?Thr?Val?Ala?Val?Ile?Ser?Asp?Gly?Thr?Ala?Val?Leu?Gly?Leu?Gly

70 75 80 85

gat?atc?gga?cct?cag?gcc?tcc?ctt?ccc?gtc?atg?gag?ggc?aag?gct?cag 403

Asp?Ile?Gly?Pro?Gln?Ala?Ser?Leu?Pro?Val?Met?Glu?Gly?Lys?Ala?Gln

90 95 100

ctg?ttt?agc?tct?ttc?gct?ggc?ctg?aag?gct?atc?cct?atc?gtt?ttg?gac 451

Leu?Phe?Ser?Ser?Phe?Ala?Gly?Leu?Lys?Ala?Ile?Pro?Ile?Val?Leu?Asp

105 110 115

gtt?cac?gat?gtt?gac?gct?ttg?gtt?gag?acc?atc?gca?gcc?atc?gcg?cct 499

Val?His?Asp?Val?Asp?Ala?Leu?Val?Glu?Thr?Ile?Ala?Ala?Ile?Ala?Pro

120 125 130

tct?ttc?ggt?gct?atc?aac?ttg?gag?gac?atc?tcc?gct?cct?cgt?tgc?ttc 547

Ser?Phe?Gly?Ala?Ile?Asn?Leu?Glu?Asp?Ile?Ser?Ala?Pro?Arg?Cys?Phe

135 140 145

gag?gtg?gag?cgc?cgc?ctc?atc?gag?cgt?ctc?gat?att?cca?gtt?atg?cac 595

Glu?Val?Glu?Arg?Arg?Leu?Ile?Glu?Arg?Leu?Asp?Ile?Pro?Val?Met?His

150 155 160 165

gat?gac?cag?cac?ggc?acc?gct?gtg?gtt?atc?ctc?gct?gcg?ctg?cgc?aac 643

Asp?Asp?Gln?His?Gly?Thr?Ala?Val?Val?Ile?Leu?Ala?Ala?Leu?Arg?Asn

170 175 180

tcc?ctg?aag?ctg?ctg?gat?cgc?aag?atc?gaa?gac?ctc?aag?att?gtt?att 691

Ser?Leu?Lys?Leu?Leu?Asp?Arg?Lys?Ile?Glu?Asp?Leu?Lys?Ile?Val?Ile

185 190 195

tcc?ggc?gca?ggc?gca?gcg?ggc?gtt?gca?gct?gta?gat?atg?ctg?acc?aac 739

Ser?Gly?Ala?Gly?Ala?Ala?Gly?Val?Ala?Ala?Val?Asp?Met?Leu?Thr?Asn

200 205 210

gct?gga?gca?acc?gac?atc?gtg?gtt?ctt?gat?tcc?cga?ggc?atc?atc?cac 787

Ala?Gly?Ala?Thr?Asp?Ile?Val?Val?Leu?Asp?Ser?Arg?Gly?Ile?Ile?His

215 220 225

gac?agc?cgt?gag?gat?ctt?tcc?cca?gtt?aag?gct?gct?ctt?gca?gag?aag 835

Asp?Ser?Arg?Glu?Asp?Leu?Ser?Pro?Val?Lys?Ala?Ala?Leu?Ala?Glu?Lys

230 235 240 245

acc?aac?cct?cgt?ggc?atc?agc?ggt?ggc?atc?aat?gag?gct?ttc?acc?ggc 883

Thr?Asn?Pro?Arg?Gly?Ile?Ser?Gly?Gly?Ile?Asn?Glu?Ala?Phe?Thr?Gly

250 255 260

gcg?gac?ctg?ttc?att?ggc?gtg?tcc?ggc?ggc?aac?atc?ggc?gag?gac?gct 931

Ala?Asp?Leu?Phe?Ile?Gly?Val?Ser?Gly?Gly?Asn?Ile?Gly?Glu?Asp?Ala

265 270 275

ctc?aaa?ctc?atg?gcc?ccg?gag?cca?atc?ctg?ttc?acc?ctg?gcg?aac?cca 979

Leu?Lys?Leu?Met?Ala?Pro?Glu?Pro?Ile?Leu?Phe?Thr?Leu?Ala?Asn?Pro

280 285 290

acc?cca?gag?atc?gat?cct?gag?ctg?tct?cag?aag?tac?ggc?gcc?atc?gtc 1027

Thr?Pro?Glu?Ile?Asp?Pro?Glu?Leu?Ser?Gln?Lys?Tyr?Gly?Ala?Ile?Val

295 300 305

gcg?acc?ggg?ccg?gtc?ttg?acc?tgc?cta?acc?aga?tca 1063

Ala?Thr?Gly?Pro?Val?Leu?Thr?Cys?Leu?Thr?Arg?Ser

310 315 320

<210>576

<211>321

<212>PRT

＜213〉Corynebacterium glutamicum

<400>576

Met?Thr?Ile?Asp?Leu?Gln?Arg?Ser?Thr?Gln?Asn?Leu?Thr?His?Glu?Glu

1 5 10 15

Ile?Phe?Glu?Ala?His?Glu?Gly?Gly?Lys?Leu?Ser?Ile?Ser?Ser?Thr?Arg

20 25 30

Pro?Leu?Arg?Asp?Met?Arg?Asp?Leu?Ser?Leu?Ala?Tyr?Thr?Pro?Gly?Val

35 40 45

Ala?Gln?Val?Cys?Glu?Ala?Ile?Lys?Glu?Asp?Pro?Glu?Val?Ala?Arg?Thr

50 55 60

His?Thr?Gly?Ile?Gly?Asn?Thr?Val?Ala?Val?Ile?Ser?Asp?Gly?Thr?Ala

65 70 75 80

Val?Leu?Gly?Leu?Gly?Asp?Ile?Gly?Pro?Gln?Ala?Ser?Leu?Pro?Val?Met

85 90 95

Glu?Gly?Lys?Ala?Gln?Leu?Phe?Ser?Ser?Phe?Ala?Gly?Leu?Lys?Ala?Ile

100 105 110

Pro?Ile?Val?Leu?Asp?Val?His?Asp?Val?Asp?Ala?Leu?Val?Glu?Thr?Ile

115 120 125

Ala?Ala?Ile?Ala?Pro?Ser?Phe?Gly?Ala?Ile?Asn?Leu?Glu?Asp?Ile?Ser

130 135 140

Ala?Pro?Arg?Cys?Phe?Glu?Val?Glu?Arg?Arg?Leu?Ile?Glu?Arg?Leu?Asp

145 150 155 160

Ile?Pro?Val?Met?His?Asp?Asp?Gln?His?Gly?Thr?Ala?Val?Val?Ile?Leu

165 170 175

Ala?Ala?Leu?Arg?Asn?Ser?Leu?Lys?Leu?Leu?Asp?Arg?Lys?Ile?Glu?Asp

180 185 190

Leu?Lys?Ile?Val?Ile?Ser?Gly?Ala?Gly?Ala?Ala?Gly?Val?Ala?Ala?Val

195 200 205

Asp?Met?Leu?Thr?Asn?Ala?Gly?Ala?Thr?Asp?Ile?Val?Val?Leu?Asp?Ser

210 215 220

Arg?Gly?Ile?Ile?His?Asp?Ser?Arg?Glu?Asp?Leu?Ser?Pro?Val?Lys?Ala

225 230 235 240

Ala?Leu?Ala?Glu?Lys?Thr?Asn?Pro?Arg?Gly?Ile?Ser?Gly?Gly?Ile?Asn

245 250 255

Glu?Ala?Phe?Thr?Gly?Ala?Asp?Leu?Phe?Ile?Gly?Val?Ser?Gly?Gly?Asn

260 265 270

Ile?Gly?Glu?Asp?Ala?Leu?Lys?Leu?Met?Ala?Pro?Glu?Pro?Ile?Leu?Phe

275 280 285

Thr?Leu?Ala?Asn?Pro?Thr?Pro?Glu?Ile?Asp?Pro?Glu?Leu?Ser?Gln?Lys

290 295 300

Tyr?Gly?Ala?Ile?Val?Ala?Thr?Gly?Pro?Val?Leu?Thr?Cys?Leu?Thr?Arg

305 310 315 320

Ser

<210>577

<211>1347

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1324)

<223>RXN01048

<400>577

agctacagat?ttagctagtg?tttttgttcc?agaaccctaa?atgaggttct?acccttaaca?60

gagcttcccg?caaaaacacc?gattaacaag?gctaaatgat?atg?acc?atc?gac?ctg 115

Met?Thr?Ile?Asp?Leu

1 5

cag?cgt?tcc?acc?caa?aac?ctc?acc?cat?gag?gaa?atc?ttc?gag?gca?cac 163

Gln?Arg?Ser?Thr?Gln?Asn?Leu?Thr?His?Glu?Glu?Ile?Phe?Glu?Ala?His

10 15 20

gag?ggc?gga?aag?ctc?tcc?att?agt?tcc?act?cgt?ccg?ctc?cgc?gac?atg 211

Glu?Gly?Gly?Lys?Leu?Ser?Ile?Ser?Ser?Thr?Arg?Pro?Leu?Arg?Asp?Met

25 30 35

cgc?gat?ctt?tcc?ctt?gct?tac?acc?cct?ggt?gtt?gct?cag?gtt?tgt?gaa 259

Arg?Asp?Leu?Ser?Leu?Ala?Tyr?Thr?Pro?Gly?Val?Ala?Gln?Val?Cys?Glu

40 45 50

gca?atc?aag?gaa?gat?cca?gag?gtt?gcg?cgc?acc?cac?acg?ggc?att?gga 307

Ala?Ile?Lys?Glu?Asp?Pro?Glu?Val?Ala?Arg?Thr?His?Thr?Gly?Ile?Gly

55 60 65

aac?acc?gtc?gcg?gtt?att?tcc?gac?ggc?acc?gct?gtt?ctt?ggc?ctt?ggc 355

Asn?Thr?Val?Ala?Val?Ile?Ser?Asp?Gly?Thr?Ala?Val?Leu?Gly?Leu?Gly

70 75 80 85

gat?atc?gga?cct?cag?gcc?tcc?ctt?ccc?gtc?atg?gag?ggc?aag?gct?cag 403

Asp?Ile?Gly?Pro?Gln?Ala?Ser?Leu?Pro?Val?Met?Glu?Gly?Lys?Ala?Gln

90 95 100

ctg?ttt?agc?tct?ttc?gct?ggc?ctg?aag?gct?atc?cct?atc?gtt?ttg?gac 451

Leu?Phe?Ser?Ser?Phe?Ala?Gly?Leu?Lys?Ala?Ile?Pro?Ile?Val?Leu?Asp

105 110 115

gtt?cac?gat?gtt?gac?gct?ttg?gtt?gag?acc?atc?gca?gcc?atc?gcg?cct 499

Val?His?Asp?Val?Asp?Ala?Leu?Val?Glu?Thr?Ile?Ala?Ala?Ile?Ala?Pro

120 125 130

tct?ttc?ggt?gct?atc?aac?ttg?gag?gac?atc?tcc?gct?cct?cgt?tgc?ttc 547

Ser?Phe?Gly?Ala?Ile?Asn?Leu?Glu?Asp?Ile?Ser?Ala?Pro?Arg?Cys?Phe

135 140 145

gag?gtg?gag?cgc?cgc?ctc?atc?gag?cgt?ctc?gat?att?cca?gtt?atg?cac 595

Glu?Val?Glu?Arg?Arg?Leu?Ile?Glu?Arg?Leu?Asp?Ile?Pro?Val?Met?His

150 155 160 165

gat?gac?cag?cac?ggc?acc?gct?gtg?gtt?atc?ctc?gct?gcg?ctg?cgc?aac 643

Asp?Asp?Gln?His?Gly?Thr?Ala?Val?Val?Ile?Leu?Ala?Ala?Leu?Arg?Asn

170 175 180

tcc?ctg?aag?ctg?ctg?gat?cgc?aag?atc?gaa?gac?ctc?aag?att?gtt?att 691

Ser?Leu?Lys?Leu?Leu?Asp?Arg?Lys?Ile?Glu?Asp?Leu?Lys?Ile?Val?Ile

185 190 195

tcc?ggc?gca?ggc?gca?gcg?ggc?gtt?gca?gct?gta?gat?atg?ctg?acc?aac 739

Ser?Gly?Ala?Gly?Ala?Ala?Gly?Val?Ala?Ala?Val?Asp?Met?Leu?Thr?Asn

200 205 210

gct?gga?gca?acc?gac?atc?gtg?gtt?ctt?gat?tcc?cga?ggc?atc?atc?cac 787

Ala?Gly?Ala?Thr?Asp?Ile?Val?Val?Leu?Asp?Ser?Arg?Gly?Ile?Ile?His

215 220 225

gac?agc?cgt?gag?gat?ctt?tcc?cca?gtt?aag?gct?gct?ctt?gca?gag?aag 835

Asp?Ser?Arg?Glu?Asp?Leu?Ser?Pro?Val?Lys?Ala?Ala?Leu?Ala?Glu?Lys

230 235 240 245

acc?aac?cct?cgt?ggc?atc?agc?ggt?ggc?atc?aat?gag?gct?ttc?acc?ggc 883

Thr?Asn?Pro?Arg?Gly?Ile?Ser?Gly?Gly?Ile?Asn?Glu?Ala?Phe?Thr?Gly

250 255 260

gcg?gac?ctg?ttc?att?ggc?gtg?tcc?ggc?ggc?aac?atc?ggc?gag?gac?gct 931

Ala?Asp?Leu?Phe?Ile?Gly?Val?Ser?Gly?Gly?Asn?Ile?Gly?Glu?Asp?Ala

265 270 275

ctc?aaa?ctc?atg?gcc?ccg?gag?cca?atc?ctg?ttc?acc?ctg?gcg?aac?cca 979

Leu?Lys?Leu?Met?Ala?Pro?Glu?Pro?Ile?Leu?Phe?Thr?Leu?Ala?Asn?Pro

280 285 290

acc?cca?gag?atc?gat?cct?gag?ctg?tct?cag?aag?tac?ggc?gcc?atc?gtc 1027

Thr?Pro?Glu?Ile?Asp?Pro?Glu?Leu?Ser?Gln?Lys?Tyr?Gly?Ala?Ile?Val

295 300 305

gcg?acc?ggg?cgc?tct?gac?ctg?cct?aac?cag?atc?aac?aac?gtg?ctg?gcg 1075

Ala?Thr?Gly?Arg?Ser?Asp?Leu?Pro?Asn?Gln?Ile?Asn?Asn?Val?Leu?Ala

310 315 320 325

ttc?cca?gga?att?ttc?gcc?ggc?gct?ctc?gca?gcc?aag?gct?aag?aag?atc 1123

Phe?Pro?Gly?Ile?Phe?Ala?Gly?Ala?Leu?Ala?Ala?Lys?Ala?Lys?Lys?Ile

330 335 340

acc?ccc?gag?atg?aag?ctc?gcc?gct?cag?agg?caa?tcg?cag?aca?tcg?cag 1171

Thr?Pro?Glu?Met?Lys?Leu?Ala?Ala?Gln?Arg?Gln?Ser?Gln?Thr?Ser?Gln

345 350 355

ctg?agg?acc?tcg?agg?tcg?gcc?gca?tcg?tgc?cta?ccg?ccc?tgg?atc?ccc 1219

Leu?Arg?Thr?Ser?Arg?Ser?Ala?Ala?Ser?Cys?Leu?Pro?Pro?Trp?Ile?Pro

360 365 370

gcg?ttg?ccc?caa?cag?tca?agg?cag?ctg?tcc?agg?ccg?tcg?cca?aag?cgc 1267

Ala?Leu?Pro?Gln?Gln?Ser?Arg?Gln?Leu?Ser?Arg?Pro?Ser?Pro?Lys?Arg

375 380 385

aaa?acg?ctt?aaa?aat?ttg?ctt?atc?gac?gcc?tcc?ctc?ccc?gtc?gag?gcg 1315

Lys?Thr?Leu?Lys?Asn?Leu?Leu?Ile?Asp?Ala?Ser?Leu?Pro?Val?Glu?Ala

390 395 400 405

cca?ata?ttt?taagagcaaa?cttgaggccc?aca 1347

Pro?Ile?Phe

<210>578

<211>408

<212>PRT

＜213〉Corynebacterium glutamicum

<400>?578

Met?Thr?Ile?Asp?Leu?Gln?Arg?Ser?Thr?Gln?Asn?Leu?Thr?His?Glu?Glu

1 5 10 15

Ile?Phe?Glu?Ala?His?Glu?Gly?Gly?Lys?Leu?Ser?Ile?Ser?Ser?Thr?Arg

20 25 30

Pro?Leu?Arg?Asp?Met?Arg?Asp?Leu?Ser?Leu?Ala?Tyr?Thr?Pro?Gly?Val

35 40 45

Ala?Gln?Val?Cys?Glu?Ala?Ile?Lys?Glu?Asp?Pro?Glu?Val?Ala?Arg?Thr

50 55 60

His?Thr?Gly?Ile?Gly?Asn?Thr?Val?Ala?Val?Ile?Ser?Asp?Gly?Thr?Ala

65 70 75 80

Val?Leu?Gly?Leu?Gly?Asp?Ile?Gly?Pro?Gln?Ala?Ser?Leu?Pro?Val?Met

85 90 95

Glu?Gly?Lys?Ala?Gln?Leu?Phe?Ser?Ser?Phe?Ala?Gly?Leu?Lys?Ala?Ile

100 105 110

Pro?Ile?Val?Leu?Asp?Val?His?Asp?Val?Asp?Ala?Leu?Val?Glu?Thr?Ile

115 120 125

Ala?Ala?Ile?Ala?Pro?Ser?Phe?Gly?Ala?Ile?Asn?Leu?Glu?Asp?Ile?Ser

130 135 140

Ala?Pro?Arg?Cys?Phe?Glu?Val?Glu?Arg?Arg?Leu?Ile?Glu?Arg?Leu?Asp

145 150 155 160

Ile?Pro?Val?Met?His?Asp?Asp?Gln?His?Gly?Thr?Ala?Val?Val?Ile?Leu

165 170 175

Ala?Ala?Leu?Arg?Asn?Ser?Leu?Lys?Leu?Leu?Asp?Arg?Lys?Ile?Glu?Asp

180 185 190

Leu?Lys?Ile?Val?Ile?Ser?Gly?Ala?Gly?Ala?Ala?Gly?Val?Ala?Ala?Val

195 200 205

Asp?Met?Leu?Thr?Asn?Ala?Gly?Ala?Thr?Asp?Ile?Val?Val?Leu?Asp?Ser

210 215 220

Arg?Gly?Ile?Ile?His?Asp?Ser?Arg?Glu?Asp?Leu?Ser?Pro?Val?Lys?Ala

225 230 235 240

Ala?Leu?Ala?Glu?Lys?Thr?Asn?Pro?Arg?Gly?Ile?Ser?Gly?Gly?Ile?Asn

245 250 255

Glu?Ala?Phe?Thr?Gly?Ala?Asp?Leu?Phe?Ile?Gly?Val?Ser?Gly?Gly?Asn

260 265 270

Ile?Gly?Glu?Asp?Ala?Leu?Lys?Leu?Met?Ala?Pro?Glu?Pro?Ile?Leu?Phe

275 280 285

Thr?Leu?Ala?Asn?Pro?Thr?Pro?Glu?Ile?Asp?Pro?Glu?Leu?Ser?Gln?Lys

290 295 300

Tyr?Gly?Ala?Ile?Val?Ala?Thr?Gly?Arg?Ser?Asp?Leu?Pro?Asn?Gln?Ile

305 310 315 320

Asn?Asn?Val?Leu?Ala?Phe?Pro?Gly?Ile?Phe?Ala?Gly?Ala?Leu?Ala?Ala

325 330 335

Lys?Ala?Lys?Lys?Ile?Thr?Pro?Glu?Met?Lys?Leu?Ala?Ala?Gln?Arg?Gln

340 345 350

Ser?Gln?Thr?Ser?Gln?Leu?Arg?Thr?Ser?Arg?Ser?Ala?Ala?Ser?Cys?Leu

355 360 365

Pro?Pro?Trp?Ile?Pro?Ala?Leu?Pro?Gln?Gln?Ser?Arg?Gln?Leu?Ser?Arg

370 375 380

Pro?Ser?Pro?Lys?Arg?Lys?Thr?Leu?Lys?Asn?Leu?Leu?Ile?Asp?Ala?Ser

385 390 395 400

Leu?Pro?Val?Glu?Ala?Pro?Ile?Phe

405

<210>579

<211>311

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..?(288)

<223>FRXA01048

<400>579

cgc?tct?gac?ttg?cct?aac?cag?atc?aac?aac?gtg?ctg?gcg?ttc?cca?gga 48

Arg?Ser?Asp?Leu?Pro?Asn?Gln?Ile?Asn?Asn?Val?Leu?Ala?Phe?Pro?Gly

1 5 10 15

att?ttc?gcc?ggc?gct?ctc?gca?gcc?aag?gct?aag?aag?atc?acc?ccc?gag 96

Ile?Phe?Ala?Gly?Ala?Leu?Ala?Ala?Lys?Ala?Lys?Lys?Ile?Thr?Pro?Glu

20 25 30

atg?aag?ctc?gcc?gct?cag?agg?caa?tcg?cag?aca?tcg?cag?ctg?agg?acc 144

Met?Lys?Leu?Ala?Ala?Gln?Arg?Gln?Ser?Gln?Thr?Ser?Gln?Leu?Arg?Thr

35 40 45

tcg?agg?tcg?gcc?gca?tcg?tgc?cta?ccg?ccc?tgg?atc?ccc?gcg?ttg?ccc 192

Ser?Arg?Ser?Ala?Ala?Ser?Cys?Leu?Pro?Pro?Trp?Ile?Pro?Ala?Leu?Pro

50 55 60

caa?cag?tca?agg?cag?ctg?tcc?agg?ccg?tcg?cca?aag?cgc?aaa?acg?ctt 240

Gln?Gln?Ser?Arg?Gln?Leu?Ser?Arg?Pro?Ser?Pro?Lys?Arg?Lys?Thr?Leu

65 70 75 80

aaa?aat?ttg?ctt?atc?gac?gcc?tcc?ctc?ccc?gtc?gag?gcg?cca?ata?ttt 288

Lys?Asn?Leu?Leu?Ile?Asp?Ala?Ser?Leu?Pro?Val?Glu?Ala?Pro?Ile?Phe

85 90 95

taagagcaaa?cttgaggccc?aca 311

<210>580

<211>96

<212>PRT

＜213〉Corynebacterium glutamicum

<400>580

Arg?Ser?Asp?Leu?Pro?Asn?Gln?Ile?Asn?Asn?Val?Leu?Ala?Phe?Pro?Gly

1 5 10 15

Ile?Phe?Ala?Gly?Ala?Leu?Ala?Ala?Lys?Ala?Lys?Lys?Ile?Thr?Pro?Glu

20 25 30

Met?Lys?Leu?Ala?Ala?Gln?Arg?Gln?Ser?Gln?Thr?Ser?Gln?Leu?Arg?Thr

35 40 45

Ser?Arg?Ser?Ala?Ala?Ser?Cys?Leu?Pro?Pro?Trp?Ile?Pro?Ala?Leu?Pro

50 55 60

Gln?Gln?Ser?Arg?Gln?Leu?Ser?Arg?Pro?Ser?Pro?Lys?Arg?Lys?Thr?Leu

65 70 75 80

Lys?Asn?Leu?Leu?Ile?Asp?Ala?Ser?Leu?Pro?Val?Glu?Ala?Pro?Ile?Phe

85 90 95

<210>581

<211>1063

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1063)

<223>FRXA00290

<400>581

agctacagat?ttagctagtg?tttttgttcc?agaaccctaa?atgaggttct?acccttaaca 60

gagcttcccg?caaaaacacc?gattaacaag?gctaaatgat?atg?acc?atc?gac?ctg 115

Met?Thr?Ile?Asp?Leu

1 5

cag?cgt?tcc?acc?caa?aac?ctc?acc?cat?gag?gaa?atc?ttc?gag?gca?cac 163

Gln?Arg?Ser?Thr?Gln?Asn?Leu?Thr?His?Glu?Glu?Ile?Phe?Glu?Ala?His

10 15 20

gag?ggc?gga?aag?ctc?tcc?att?agt?tcc?act?cgt?ccg?ctc?cgc?gac?atg 211

Glu?Gly?Gly?Lys?Leu?Ser?Ile?Ser?Ser?Thr?Arg?Pro?Leu?Arg?Asp?Met

25 30 35

cgc?gat?ctt?tcc?ctt?gct?tac?acc?cct?ggt?gtt?gct?cag?gtt?tgt?gaa 259

Arg?Asp?Leu?Ser?Leu?Ala?Tyr?Thr?Pro?Gly?Val?Ala?Gln?Val?Cys?Glu

40 45 50

gca?atc?aag?gaa?gat?cca?gag?gtt?gcg?cgc?acc?cac?acg?ggc?att?gga 307

Ala?Ile?Lys?Glu?Asp?Pro?Glu?Val?Ala?Arg?Thr?His?Thr?Gly?Ile?Gly

55 60 65

aac?acc?gtc?gcg?gtt?att?tcc?gac?ggc?acc?gct?gtt?ctt?ggc?ctt?ggc 355

Asn?Thr?Val?Ala?Val?Ile?Ser?Asp?Gly?Thr?Ala?Val?Leu?Gly?Leu?Gly

70 75 80 85

gat?atc?gga?cct?cag?gcc?tcc?ctt?ccc?gtc?atg?gag?ggc?aag?gct?cag 403

Asp?Ile?Gly?Pro?Gln?Ala?Ser?Leu?Pro?Val?Met?Glu?Gly?Lys?Ala?Gln

90 95 100

ctg?ttt?agc?tct?ttc?gct?ggc?ctg?aag?gct?atc?cct?atc?gtt?ttg?gac 451

Leu?Phe?Ser?Ser?Phe?Ala?Gly?Leu?Lys?Ala?Ile?Pro?Ile?Val?Leu?Asp

105 110 115

gtt?cac?gat?gtt?gac?gct?ttg?gtt?gag?acc?atc?gca?gcc?atc?gcg?cct 499

Val?His?Asp?Val?Asp?Ala?Leu?Val?Glu?Thr?Ile?Ala?Ala?Ile?Ala?Pro

120 125 130

tct?ttc?ggt?gct?atc?aac?ttg?gag?gac?atc?tcc?gct?cct?cgt?tgc?ttc 547

Ser?Phe?Gly?Ala?Ile?Asn?Leu?Glu?Asp?Ile?Ser?Ala?Pro?Arg?Cys?Phe

135 140 145

gag?gtg?gag?cgc?cgc?ctc?atc?gag?cgt?ctc?gat?att?cca?gtt?atg?cac 595

Glu?Val?Glu?Arg?Arg?Leu?Ile?Glu?Arg?Leu?Asp?Ile?Pro?Val?Met?His

150 155 160 165

gat?gac?cag?cac?ggc?acc?gct?gtg?gtt?atc?ctc?gct?gcg?ctg?cgc?aac 643

Asp?Asp?Gln?His?Gly?Thr?Ala?Val?Val?Ile?Leu?Ala?Ala?Leu?Arg?Asn

170 175 180

tcc?ctg?aag?ctg?ctg?gat?cgc?aag?atc?gaa?gac?ctc?aag?att?gtt?att 691

Ser?Leu?Lys?Leu?Leu?Asp?Arg?Lys?Ile?Glu?Asp?Leu?Lys?Ile?Val?Ile

185 190 195

tcc?ggc?gca?ggc?gca?gcg?ggc?gtt?gca?gct?gta?gat?atg?ctg?acc?aac 739

Ser?Gly?Ala?Gly?Ala?Ala?Gly?Val?Ala?Ala?Val?Asp?Met?Leu?Thr?Asn

200 205 210

gct?gga?gca?acc?gac?atc?gtg?gtt?ctt?gat?tcc?cga?ggc?atc?atc?cac 787

Ala?Gly?Ala?Thr?Asp?Ile?Val?Val?Leu?Asp?Ser?Arg?Gly?Ile?Ile?His

215 220 225

gac?agc?cgt?gag?gat?ctt?tcc?cca?gtt?aag?gct?gct?ctt?gca?gag?aag 835

Asp?Ser?Arg?Glu?Asp?Leu?Ser?Pro?Val?Lys?Ala?Ala?Leu?Ala?Glu?Lys

230 235 240 245

acc?aac?cct?cgt?ggc?atc?agc?ggt?ggc?atc?aat?gag?gct?ttc?acc?ggc 883

Thr?Asn?Pro?Arg?Gly?Ile?Ser?Gly?Gly?Ile?Asn?Glu?Ala?Phe?Thr?Gly

250 255 260

gcg?gac?ctg?ttc?att?ggc?gtg?tcc?ggc?ggc?aac?atc?ggc?gag?gac?gct 931

Ala?Asp?Leu?Phe?Ile?Gly?Val?Ser?Gly?Gly?Asn?Ile?Gly?Glu?Asp?Ala

265 270 275

ctc?aaa?ctc?atg?gcc?ccg?gag?cca?atc?ctg?ttc?acc?ctg?gcg?aac?cca 979

Leu?Lys?Leu?Met?Ala?Pro?Glu?Pro?Ile?Leu?Phe?Thr?Leu?Ala?Asn?Pro

280 285 290

acc?cca?gag?atc?gat?cct?gag?ctg?tct?cag?aag?tac?ggc?gcc?atc?gtc 1027

Thr?Pro?Glu?Ile?Asp?Pro?Glu?Leu?Ser?Gln?Lys?Tyr?Gly?Ala?Ile?Val

295 300 305

gcg?acc?ggg?ccg?gtc?ttg?acc?tgc?cta?acc?aga?tca 1063

Ala?Thr?Gly?Pro?Val?Leu?Thr?Cys?Leu?Thr?Arg?Ser

310 315 320

<210>582

<211>321

<212>PRT

＜213〉Corynebacterium glutamicum

<400>?582

Met?Thr?Ile?Asp?Leu?Gln?Arg?Ser?Thr?Gln?Asn?Leu?Thr?His?Glu?Glu

1 5 10 15

Ile?Phe?Glu?Ala?His?Glu?Gly?Gly?Lys?Leu?Ser?Ile?Ser?Ser?Thr?Arg

20 25 30

Pro?Leu?Arg?Asp?Met?Arg?Asp?Leu?Ser?Leu?Ala?Tyr?Thr?Pro?Gly?Val

35 40 45

Ala?Gln?Val?Cys?Glu?Ala?Ile?Lys?Glu?Asp?Pro?Glu?Val?Ala?Arg?Thr

50 55 60

His?Thr?Gly?Ile?Gly?Asn?Thr?Val?Ala?Val?Ile?Ser?Asp?Gly?Thr?Ala

65 70 75 80

Val?Leu?Gly?Leu?Gly?Asp?Ile?Gly?Pro?Gln?Ala?Ser?Leu?Pro?Val?Met

85 90 95

Glu?Gly?Lys?Ala?Gln?Leu?Phe?Ser?Ser?Phe?Ala?Gly?Leu?Lys?Ala?Ile

100 105 110

Pro?Ile?Val?Leu?Asp?Val?His?Asp?Val?Asp?Ala?Leu?Val?Glu?Thr?Ile

115 120 125

Ala?Ala?Ile?Ala?Pro?Ser?Phe?Gly?Ala?Ile?Asn?Leu?Glu?Asp?Ile?Ser

130 135 140

Ala?Pro?Arg?Cys?Phe?Glu?Val?Glu?Arg?Arg?Leu?Ile?Glu?Arg?Leu?Asp

145 150 155 160

Ile?Pro?Val?Met?His?Asp?Asp?Gln?His?Gly?Thr?Ala?Val?Val?Ile?Leu

165 170 175

Ala?Ala?Leu?Arg?Asn?Ser?Leu?Lys?Leu?Leu?Asp?Arg?Lys?Ile?Glu?Asp

180 185 190

Leu?Lys?Ile?Val?Ile?Ser?Gly?Ala?Gly?Ala?Ala?Gly?Val?Ala?Ala?Val

195 200 205

Asp?Met?Leu?Thr?Asn?Ala?Gly?Ala?Thr?Asp?Ile?Val?Val?Leu?Asp?Ser

210 215 220

Arg?Gly?Ile?Ile?His?Asp?Ser?Arg?Glu?Asp?Leu?Ser?Pro?Val?Lys?Ala

225 230 235 240

Ala?Leu?Ala?Glu?Lys?Thr?Asn?Pro?Arg?Gly?Ile?Ser?Gly?Gly?Ile?Asn

245 250 255

Glu?Ala?Phe?Thr?Gly?Ala?Asp?Leu?Phe?Ile?Gly?Val?Ser?Gly?Gly?Asn

260 265 270

Ile?Gly?Glu?Asp?Ala?Leu?Lys?Leu?Met?Ala?Pro?Glu?Pro?Ile?Leu?Phe

275 280 285

Thr?Leu?Ala?Asn?Pro?Thr?Pro?Glu?Ile?Asp?Pro?Glu?Leu?Ser?Gln?Lys

290 295 300

Tyr?Gly?Ala?Ile?Val?Ala?Thr?Gly?Pro?Val?Leu?Thr?Cys?Leu?Thr?Arg

305 310 315 320

Ser

<210>583

<211>582

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(582)

<223>RXN03101

<400>583

atc?ctt?gca?gac?gaa?gac?gac?acc?gtc?gac?gtc?ggc?gca?gtc?atc?gcc 48

Ile?Leu?Ala?Asp?Glu?Asp?Asp?Thr?Val?Asp?Val?Gly?Ala?Val?Ile?Ala

1 5 10 15

cgc?atc?ggt?gac?gca?aac?gca?gct?gca?gca?cct?gcc?gaa?gag?gaa?gca 96

Arg?Ile?Gly?Asp?Ala?Asn?Ala?Ala?Ala?Ala?Pro?Ala?Glu?Glu?Glu?Ala

20 25 30

gct?cct?gcc?gaa?gag?gaa?gaa?cca?gtt?aag?gaa?gag?cca?aag?aag?gag 144

Ala?Pro?Ala?Glu?Glu?Glu?Glu?Pro?Val?Lys?Glu?Glu?Pro?Lys?Lys?Glu

35 40 45

gca?gct?cct?gaa?gct?cca?gca?gca?act?ggc?gcc?gca?acc?gat?gtg?gaa 192

Ala?Ala?Pro?Glu?Ala?Pro?Ala?Ala?Thr?Gly?Ala?Ala?Thr?Asp?Val?Glu

50 55 60

atg?cca?gaa?ctc?ggc?gaa?tcc?gtc?acc?gaa?ggc?acc?att?acc?cag?tgg 240

Met?Pro?Glu?Leu?Gly?Glu?Ser?Val?Thr?Glu?Gly?Thr?Ile?Thr?Gln?Trp

65 70 75 80

ctc?aag?gct?gtc?ggc?gac?acc?gtc?gaa?gta?gac?gaa?cca?ctt?ctt?gag 288

Leu?Lys?Ala?Val?Gly?Asp?Thr?Val?Glu?Val?Asp?Glu?Pro?Leu?Leu?Glu

85 90 95

gtc?tcc?acc?gac?aag?gtc?gac?acc?gaa?atc?cca?tcc?cca?gta?gca?ggc 336

Val?Ser?Thr?Asp?Lys?Val?Asp?Thr?Glu?Ile?Pro?Ser?Pro?Val?Ala?Gly

100 105 110

acc?atc?gtg?gag?atc?ctt?gca?gac?gaa?gac?gac?acc?gtc?gac?gtc?ggc 384

Thr?Ile?Val?Glu?Ile?Leu?Ala?Asp?Glu?Asp?Asp?Thr?Val?Asp?Val?Gly

115 120 125

gca?gtc?atc?gcc?cgc?atc?ggt?gac?gca?aac?gca?gct?gca?gca?cct?gcc 432

Ala?Val?Ile?Ala?Arg?Ile?Gly?Asp?Ala?Asn?Ala?Ala?Ala?Ala?Pro?Ala

130 135 140

gaa?gag?gaa?gca?gct?cct?gcc?gaa?gag?gag?gaa?cca?gtt?aag?gaa?gag 480

Glu?Glu?Glu?Ala?Ala?Pro?Ala?Glu?Glu?Glu?Glu?Pro?Val?Lys?Glu?Glu

145 150 155 160

cca?aag?aag?gaa?gag?ccc?aag?aag?gaa?gag?ccc?aag?aag?gaa?gca?gct 528

Pro?Lys?Lys?Glu?Glu?Pro?Lys?Lys?Glu?Glu?Pro?Lys?Lys?Glu?Ala?Ala

165 170 175

act?aca?cct?gct?gcg?gca?tcc?gca?act?gtg?tcc?gct?tct?ggc?gac?aac 576

Thr?Thr?Pro?Ala?Ala?Ala?Ser?Ala?Thr?Val?Ser?Ala?Ser?Gly?Asp?Asn

180 185 190

gtt?cca 582

Val?Pro

<210>584

<211>194

<212>PRT

＜213〉Corynebacterium glutamicum

<400>584

Ile?Leu?Ala?Asp?Glu?Asp?Asp?Thr?Val?Asp?Val?Gly?Ala?Val?Ile?Ala

1 5 10 15

Arg?Ile?Gly?Asp?Ala?Asn?Ala?Ala?Ala?Ala?Pro?Ala?Glu?Glu?Glu?Ala

20 25 30

Ala?Pro?Ala?Glu?Glu?Glu?Glu?Pro?Val?Lys?Glu?Glu?Pro?Lys?Lys?Glu

35 40 45

Ala?Ala?Pro?Glu?Ala?Pro?Ala?Ala?Thr?Gly?Ala?Ala?Thr?Asp?Val?Glu

50 55 60

Met?Pro?Glu?Leu?Gly?Glu?Ser?Val?Thr?Glu?Gly?Thr?Ile?Thr?Gln?Trp

65 70 75 80

Leu?Lys?Ala?Val?Gly?Asp?Thr?Val?Glu?Val?Asp?Glu?Pro?Leu?Leu?Glu

85 90 95

Val?Ser?Thr?Asp?Lys?Val?Asp?Thr?Glu?Ile?Pro?Ser?Pro?Val?Ala?Gly

100 105 110

Thr?Ile?Val?Glu?Ile?Leu?Ala?Asp?Glu?Asp?Asp?Thr?Val?Asp?Val?Gly

115 120 125

Ala?Val?Ile?Ala?Arg?Ile?Gly?Asp?Ala?Asn?Ala?Ala?Ala?Ala?Pro?Ala

130 135 140

Glu?Glu?Glu?Ala?Ala?Pro?Ala?Glu?Glu?Glu?Glu?Pro?Val?Lys?Glu?Glu

145 150 155 160

Pro?Lys?Lys?Glu?Glu?Pro?Lys?Lys?Glu?Glu?Pro?Lys?Lys?Glu?Ala?Ala

165 170 175

Thr?Thr?Pro?Ala?Ala?Ala?Ser?Ala?Thr?Val?Ser?Ala?Ser?Gly?Asp?Asn

180 185 190

Val?Pro

<210>585

<211>540

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(517)

<223>RXN02046

<400>585

tccgtgccat?caccaccggc?gagatcactg?gcatcgtgga?cgcaaaacaa?acagcaacag 60

aaattattaa?catccgacgc?aacgcttcag?gagagtcctc?atg?aaa?gag?aca?ctg 115

Met?Lys?Glu?Thr?Leu

1 5

acc?acc?ggt?tta?acc?cac?caa?atg?acc?tac?ata?gtg?cca?gca?aac?cgc 163

Thr?Thr?Gly?Leu?Thr?His?Gln?Met?Thr?Tyr?Ile?Val?Pro?Ala?Asn?Arg

10 15 20

aca?gtt?ccg?cat?ctg?ctt?ccc?gaa?gca?gca?gaa?ttt?gaa?acc?atg?cca 211

Thr?Val?Pro?His?Leu?Leu?Pro?Glu?Ala?Ala?Glu?Phe?Glu?Thr?Met?Pro

25 30 35

gat?gtc?ctg?gcc?act?gga?tat?atg?gtc?ggc?atc?atc?gag?tgg?gcc?tgc 259

Asp?Val?Leu?Ala?Thr?Gly?Tyr?Met?Val?Gly?Ile?Ile?Glu?Trp?Ala?Cys

40 45 50

atg?gaa?ctt?ctg?cgt?ccc?cat?ttg?gac?gac?ggt?gaa?atc?tcg?ctg?ggc 307

Met?Glu?Leu?Leu?Arg?Pro?His?Leu?Asp?Asp?Gly?Glu?Ile?Ser?Leu?Gly

55 60 65

act?cat?gtg?aac?ttc?tcc?cac?gca?gct?cca?acg?gtt?cct?gga?tcc?acg 355

Thr?His?Val?Asn?Phe?Ser?His?Ala?Ala?Pro?Thr?Val?Pro?Gly?Ser?Thr

70 75 80 85

gtc?acc?atc?gat?gtt?gag?gtg?aca?gag?atc?aac?cgt?cgt?gca?gtt?acc 403

Val?Thr?Ile?Asp?Val?Glu?Val?Thr?Glu?Ile?Asn?Arg?Arg?Ala?Val?Thr

90 95 100

ttc?aac?atc?act?gca?gct?gat?gag?ttc?gcc?acc?atc?agc?acc?ggc?acc 451

Phe?Asn?Ile?Thr?Ala?Ala?Asp?Glu?Phe?Ala?Thr?Ile?Ser?Thr?Gly?Thr

105 110 115

cac?cag?cgc?ggt?gtg?gtt?aac?cgt?gag?aag?ttt?gtc?tcc?cgt?ctg?cct 499

His?Gln?Arg?Gly?Val?Val?Asn?Arg?Glu?Lys?Phe?Val?Ser?Arg?Leu?Pro

120 125 130

gaa?gca?cct?aag?gaa?aac?taaatcatgg?ccaagttgtt?tga 540

Glu?Ala?Pro?Lys?Glu?Asn

135

<210>586

<211>139

<212>PRT

＜213〉Corynebacterium glutamicum

<400>586

Met?Lys?Glu?Thr?Leu?Thr?Thr?Gly?Leu?Thr?His?Gln?Met?Thr?Tyr?Ile

1 5 10 15

Val?Pro?Ala?Asn?Arg?Thr?Val?Pro?His?Leu?Leu?Pro?Glu?Ala?Ala?Glu

20 25 30

Phe?Glu?Thr?Met?Pro?Asp?Val?Leu?Ala?Thr?Gly?Tyr?Met?Val?Gly?Ile

35 40 45

Ile?Glu?Trp?Ala?Cys?Met?Glu?Leu?Leu?Arg?Pro?His?Leu?Asp?Asp?Gly

50 55 60

Glu?Ile?Ser?Leu?Gly?Thr?His?Val?Asn?Phe?Ser?His?Ala?Ala?Pro?Thr

65 70 75 80

Val?Pro?Gly?Ser?Thr?Val?Thr?Ile?Asp?Val?Glu?Val?Thr?Glu?Ile?Asn

85 90 95

Arg?Arg?Ala?Val?Thr?Phe?Asn?Ile?Thr?Ala?Ala?Asp?Glu?Phe?Ala?Thr

100 105 110

Ile?Ser?Thr?Gly?Thr?His?Gln?Arg?Gly?Val?Val?Asn?Arg?Glu?Lys?Phe

115 120 125

Val?Ser?Arg?Leu?Pro?Glu?Ala?Pro?Lys?Glu?Asn

130 135

<210>587

<211>1683

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1660)

<223>RXN00389

<400>587

ccaccactgc?gtaacctttc?cgagcaagat?atcgcggacc?tgtcggattt?gcttgccacc 60

tctggcgcag?gttcctaccg?ccttcagttg?aggtgaaagc?atg?atc?acc?gca?acc 115

Met?Ile?Thr?Ala?Thr

1 5

gca?ctg?cat?ggg?tgt?tca?ctg?att?gat?ggc?gag?tgg?gtc?gct?gga?aaa 163

Ala?Leu?His?Gly?Cys?Ser?Leu?Ile?Asp?Gly?Glu?Trp?Val?Ala?Gly?Lys

10 15 20

aat?ggt?gag?att?aca?gga?ttc?gat?ccg?cgc?acc?aat?gcg?agt?ctg?aac 211

Asn?Gly?Glu?Ile?Thr?Gly?Phe?Asp?Pro?Arg?Thr?Asn?Ala?Ser?Leu?Asn

25 30 35

cct?tcc?tac?tct?tta?gca?aac?agc?gca?cag?ctg?cgc?gcc?gcc?aca?aca 259

Pro?Ser?Tyr?Ser?Leu?Ala?Asn?Ser?Ala?Gln?Leu?Arg?Ala?Ala?Thr?Thr

40 45 50

tcg?gcg?aag?cga?gct?ttt?gaa?agc?tac?cga?ctc?act?act?cca?gag?gtt 307

Ser?Ala?Lys?Arg?Ala?Phe?Glu?Ser?Tyr?Arg?Leu?Thr?Thr?Pro?Glu?Val

55 60 65

aga?gca?gat?ttc?ctg?gat?tcc?atc?gct?gac?aac?atc?gat?gcg?cta?tcc 355

Arg?Ala?Asp?Phe?Leu?Asp?Ser?Ile?Ala?Asp?Asn?Ile?Asp?Ala?Leu?Ser

70 75 80 85

ggc?gag?atc?gtg?caa?cgg?gcg?agc?ctg?gag?aca?ggt?ttg?gga?act?acc 403

Gly?Glu?Ile?Val?Gln?Arg?Ala?Ser?Leu?Glu?Thr?Gly?Leu?Gly?Thr?Thr

90 95 100

cga?ctc?aca?ggc?gaa?gta?gcc?cgc?acc?agc?aac?cag?ctc?cgc?ctg?ttt 451

Arg?Leu?Thr?Gly?Glu?Val?Ala?Arg?Thr?Ser?Asn?Gln?Leu?Arg?Leu?Phe

105 110 115

gca?gaa?acc?gtg?aga?agc?gga?cag?ttc?cac?cga?gta?cgc?att?gaa?cga 499

Ala?Glu?Thr?Val?Arg?Ser?Gly?Gln?Phe?His?Arg?Val?Arg?Ile?Glu?Arg

120 125 130

gga?ccg?cgg?att?gat?ctt?cgc?cag?cgt?cag?gtt?ccg?ttg?gga?cca?gtc 547

Gly?Pro?Arg?Ile?Asp?Leu?Arg?Gln?Arg?Gln?Val?Pro?Leu?Gly?Pro?Val

135 140 145

gcg?gta?ttc?ggg?gca?agc?aac?ttc?ccc?gtc?gct?ttc?tct?act?gct?ggt 595

Ala?Val?Phe?Gly?Ala?Ser?Asn?Phe?Pro?Val?Ala?Phe?Ser?Thr?Ala?Gly

150 155 160 165

ggc?gat?aca?gca?tca?gcg?ttg?gct?gca?ggc?tgc?cct?gtg?gtt?ttt?aag 643

Gly?Asp?Thr?Ala?Ser?Ala?Leu?Ala?Ala?Gly?Cys?Pro?Val?Val?Phe?Lys

170 175 180

gcg?cat?aat?gcg?cac?cct?gga?aca?gct?gag?ctc?gtc?ggg?caa?gcg?gtg 691

Ala?His?Asn?Ala?His?Pro?Gly?Thr?Ala?Glu?Leu?Val?Gly?Gln?Ala?Val

185 190 195

cgg?gga?gcc?gtc?gaa?aag?cat?gag?ttt?gat?gct?ggt?gtg?ttt?aac?ctt 739

Arg?Gly?Ala?Val?Glu?Lys?His?Glu?Phe?Asp?Ala?Gly?Val?Phe?Asn?Leu

200 205 210

gtc?tac?ggc?cgt?ggc?gtg?gaa?att?ggc?cag?gag?ctg?gct?gcg?gat?ccg 787

Val?Tyr?Gly?Arg?Gly?Val?Glu?Ile?Gly?Gln?Glu?Leu?Ala?Ala?Asp?Pro

215 220 225

aat?atc?acg?gca?atc?ggt?ttt?acc?ggt?tca?cgc?cag?ggt?ggt?ttg?gca 835

Asn?Ile?Thr?Ala?Ile?Gly?Phe?Thr?Gly?Ser?Arg?Gln?Gly?Gly?Leu?Ala

230 235 240 245

ctg?tca?cag?act?gcg?ttt?agc?cgc?cca?gtt?ccc?gtt?cca?gtc?ttt?gca 883

Leu?Ser?Gln?Thr?Ala?Phe?Ser?Arg?Pro?Val?Pro?Val?Pro?Val?Phe?Ala

250 255 260

gaa?atg?agt?gcc?acc?aac?cct?gtg?ttc?gtc?ttc?ccc?ggc?gcg?ctg?gcg 931

Glu?Met?Ser?Ala?Thr?Asn?Pro?Val?Phe?Val?Phe?Pro?Gly?Ala?Leu?Ala

265 270 275

gat?ttg?gat?gca?tcg?agt?tcc?ttg?gct?gag?gcg?ttt?acc?gct?tcc?gtc 979

Asp?Leu?Asp?Ala?Ser?Ser?Ser?Leu?Ala?Glu?Ala?Phe?Thr?Ala?Ser?Val

280 285 290

acc?ggc?agt?tcc?ggg?caa?ttg?tgc?acc?aag?cct?ggc?ctc?gtt?ttc?atc 1027

Thr?Gly?Ser?Ser?Gly?Gln?Leu?Cys?Thr?Lys?Pro?Gly?Leu?Val?Phe?Ile

295 300 305

ccg?cgc?ggt?gtt?gtt?ggt?gat?gct?ttt?gtg?gcg?ctc?gta?gca?gcc?aaa 1075

Pro?Arg?Gly?Val?Val?Gly?Asp?Ala?Phe?Val?Ala?Leu?Val?Ala?Ala?Lys

310 315 320 325

ttt?aaa?gaa?acc?acg?ggt?caa?acg?atg?ctc?acg?caa?ggc?atc?gct?cag 1123

Phe?Lys?Glu?Thr?Thr?Gly?Gln?Thr?Met?Leu?Thr?Gln?Gly?Ile?Ala?Gln

330 335 340

gca?tgg?cag?cgc?gga?gtc?gac?aac?ctt?gca?gca?cag?cca?agt?gta?aaa 1171

Ala?Trp?Gln?Arg?Gly?Val?Asp?Asn?Leu?Ala?Ala?Gln?Pro?Ser?Val?Lys

345 350 355

atc?ctc?gcc?caa?ggc?acc?ccc?gga?gat?gga?gag?aac?gcg?ccg?ggc?ccg 1219

Ile?Leu?Ala?Gln?Gly?Thr?Pro?Gly?Asp?Gly?Glu?Asn?Ala?Pro?Gly?Pro

360 365 370

gtg?gtg?ttt?gaa?agt?gat?gtg?cag?gcg?ttg?cta?aat?aat?gtg?gtg?ttg 1267

Val?Val?Phe?Glu?Ser?Asp?Val?Gln?Ala?Leu?Leu?Asn?Asn?Val?Val?Leu

375 380 385

cag?gaa?gaa?atc?ttc?ggt?gcg?gca?tcg?ctg?gtg?gtg?cgt?tat?gat?tcc 1315

Gln?Glu?Glu?Ile?Phe?Gly?Ala?Ala?Ser?Leu?Val?Val?Arg?Tyr?Asp?Ser

390 395 400 405

ccg?gat?caa?ctc?cac?caa?gta?gcc?aat?tca?ctc?gag?gga?caa?tta?aca 1363

Pro?Asp?Gln?Leu?His?Gln?Val?Ala?Asn?Ser?Leu?Glu?Gly?Gln?Leu?Thr

410 415 420

gcc?acg?atc?cac?gca?tcc?cag?gat?gat?ttc?cag?gaa?gtc?tcg?aaa?ctt 1411

Ala?Thr?Ile?His?Ala?Ser?Gln?Asp?Asp?Phe?Gln?Glu?Val?Ser?Lys?Leu

425 430 435

atc?ccc?ctc?ttg?gag?gat?ctc?gcg?ggc?cgt?gtt?ctt?tac?ggc?ggc?tgg 1459

Ile?Pro?Leu?Leu?Glu?Asp?Leu?Ala?Gly?Arg?Val?Leu?Tyr?Gly?Gly?Trp

440 445 450

cca?acg?ggt?gtg?gaa?gtt?ggg?cac?acg?gtt?atc?cat?gga?ggc?cct?tat 1507

Pro?Thr?Gly?Val?Glu?Val?Gly?His?Thr?Val?Ile?His?Gly?Gly?Pro?Tyr

455 460 465

ccg?gcg?acc?tca?aat?gcg?cag?tcg?aca?agt?gtt?gga?acc?ctg?gca?atc 1555

Pro?Ala?Thr?Ser?Asn?Ala?Gln?Ser?Thr?Ser?Val?Gly?Thr?Leu?Ala?Ile

470 475 480 485

gag?aga?ttt?atg?cgc?ccg?gtt?tct?tat?caa?act?ttc?ccg?gct?gag?ctg 1603

Glu?Arg?Phe?Met?Arg?Pro?Val?Ser?Tyr?Gln?Thr?Phe?Pro?Ala?Glu?Leu

490 495 500

ctt?cca?gat?cca?gtt?tct?gag?gcg?aat?aaa?tgg?gct?gta?cct?cgg?gaa 1651

Leu?Pro?Asp?Pro?Val?Ser?Glu?Ala?Asn?Lys?Trp?Ala?Val?Pro?Arg?Glu

505 510 515

ata?gac?cgt?taatagctgg?tctttacatt?tgc 1683

Ile?Asp?Arg

520

<210>588

<211>520

<212>PRT

＜213〉Corynebacterium glutamicum

<400>588

Met?Ile?Thr?Ala?Thr?Ala?Leu?His?Gly?Cys?Ser?Leu?Ile?Asp?Gly?Glu

1 5 10 15

Trp?Val?Ala?Gly?Lys?Asn?Gly?Glu?Ile?Thr?Gly?Phe?Asp?Pro?Arg?Thr

20 25 30

Asn?Ala?Ser?Leu?Asn?Pro?Ser?Tyr?Ser?Leu?Ala?Asn?Ser?Ala?Gln?Leu

35 40 45

Arg?Ala?Ala?Thr?Thr?Ser?Ala?Lys?Arg?Ala?Phe?Glu?Ser?Tyr?Arg?Leu

50 55 60

Thr?Thr?Pro?Glu?Val?Arg?Ala?Asp?Phe?Leu?Asp?Ser?Ile?Ala?Asp?Asn

65 70 75 80

Ile?Asp?Ala?Leu?Ser?Gly?Glu?Ile?Val?Gln?Arg?Ala?Ser?Leu?Glu?Thr

85 90 95

Gly?Leu?Gly?Thr?Thr?Arg?Leu?Thr?Gly?Glu?Val?Ala?Arg?Thr?Ser?Asn

100 105 110

Gln?Leu?Arg?Leu?Phe?Ala?Glu?Thr?Val?Arg?Ser?Gly?Gln?Phe?His?Arg

115 120 125

Val?Arg?Ile?Glu?Arg?Gly?Pro?Arg?Ile?Asp?Leu?Arg?Gln?Arg?Gln?Val

130 135 140

Pro?Leu?Gly?Pro?Val?Ala?Val?Phe?Gly?Ala?Ser?Asn?Phe?Pro?Val?Ala

145 150 155 160

Phe?Ser?Thr?Ala?Gly?Gly?Asp?Thr?Ala?Ser?Ala?Leu?Ala?Ala?Gly?Cys

165 170 175

Pro?Val?Val?Phe?Lys?Ala?His?Asn?Ala?His?Pro?Gly?Thr?Ala?Glu?Leu

180 185 190

Val?Gly?Gln?Ala?Val?Arg?Gly?Ala?Val?Glu?Lys?His?Glu?Phe?Asp?Ala

195 200 205

Gly?Val?Phe?Asn?Leu?Val?Tyr?Gly?Arg?Gly?Val?Glu?Ile?Gly?Gln?Glu

210 215 220

Leu?Ala?Ala?Asp?Pro?Asn?Ile?Thr?Ala?Ile?Gly?Phe?Thr?Gly?Ser?Arg

225 230 235 240

Gln?Gly?Gly?Leu?Ala?Leu?Ser?Gln?Thr?Ala?Phe?Ser?Arg?Pro?Val?Pro

245 250 255

Val?Pro?Val?Phe?Ala?Glu?Met?Ser?Ala?Thr?Asn?Pro?Val?Phe?Val?Phe

260 265 270

Pro?Gly?Ala?Leu?Ala?Asp?Leu?Asp?Ala?Ser?Ser?Ser?Leu?Ala?Glu?Ala

275 280 285

Phe?Thr?Ala?Ser?Val?Thr?Gly?Ser?Ser?Gly?Gln?Leu?Cys?Thr?Lys?Pro

290 295 300

Gly?Leu?Val?Phe?Ile?Pro?Arg?Gly?Val?Val?Gly?Asp?Ala?Phe?Val?Ala

305 310 315 320

Leu?Val?Ala?Ala?Lys?Phe?Lys?Glu?Thr?Thr?Gly?Gln?Thr?Met?Leu?Thr

325 330 335

Gln?Gly?Ile?Ala?Gln?Ala?Trp?Gln?Arg?Gly?Val?Asp?Asn?Leu?Ala?Ala

340 345 350

Gln?Pro?Ser?Val?Lys?Ile?Leu?Ala?Gln?Gly?Thr?Pro?Gly?Asp?Gly?Glu

355 360 365

Asn?Ala?Pro?Gly?Pro?Val?Val?Phe?Glu?Ser?Asp?Val?Gln?Ala?Leu?Leu

370 375 380

Asn?Asn?Val?Val?Leu?Gln?Glu?Glu?Ile?Phe?Gly?Ala?Ala?Ser?Leu?Val

385 390 395 400

Val?Arg?Tyr?Asp?Ser?Pro?Asp?Gln?Leu?His?Gln?Val?Ala?Asn?Ser?Leu

405 410 415

Glu?Gly?Gln?Leu?Thr?Ala?Thr?Ile?His?Ala?Ser?Gln?Asp?Asp?Phe?Gln

420 425 430

Glu?Val?Ser?Lys?Leu?Ile?Pro?Leu?Leu?Glu?Asp?Leu?Ala?Gly?Arg?Val

435 440 445

Leu?Tyr?Gly?Gly?Trp?Pro?Thr?Gly?Val?Glu?Val?Gly?His?Thr?Val?Ile

450 455 460

His?Gly?Gly?Pro?Tyr?Pro?Ala?Thr?Ser?Asn?Ala?Gln?Ser?Thr?Ser?Val

465 470 475 480

Gly?Thr?Leu?Ala?Ile?Glu?Arg?Phe?Met?Arg?Pro?Val?Ser?Tyr?Gln?Thr

485 490 495

Phe?Pro?Ala?Glu?Leu?Leu?Pro?Asp?Pro?Val?Ser?Glu?Ala?Asn?Lys?Trp

500 505 510

Ala?Val?Pro?Arg?Glu?Ile?Asp?Arg

515 520

<210>589

<211>1467

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1444)

<223>RXN02399

<400>589

ttgacgcacc?aatgcccgat?ggagcaatgt?gtgaaccacg?ccaccacgca?aaccgatgca 60

catcacgtcg?aaacagtgac?agtgcattag?ctcatacttt?gtg?gtc?ggc?acc?gcc 115

Val?Val?Gly?Thr?Ala

1 5

cat?tgc?gaa?tca?gca?ctt?aag?gaa?gtg?act?ttg?atg?tca?aac?gtt?gga 163

His?Cys?Glu?Ser?Ala?Leu?Lys?Glu?Val?Thr?Leu?Met?Ser?Asn?Val?Gly

10 15 20

aag?cca?cgt?acc?gca?cag?gaa?atc?cag?cag?gat?tgg?gac?acc?aac?cct 211

Lys?Pro?Arg?Thr?Ala?Gln?Glu?Ile?Gln?Gln?Asp?Trp?Asp?Thr?Asn?Pro

25 30 35

cgt?tgg?aac?ggc?atc?acc?cgc?gac?tac?acc?gca?gac?cag?gta?gct?gat 259

Arg?Trp?Asn?Gly?Ile?Thr?Arg?Asp?Tyr?Thr?Ala?Asp?Gln?Val?Ala?Asp

40 45 50

ctg?cag?ggt?tcc?gtc?atc?gag?gag?cac?act?ctt?gct?cgc?cgc?ggc?tca 307

Leu?Gln?Gly?Ser?Val?Ile?Glu?Glu?His?Thr?Leu?Ala?Arg?Arg?Gly?Ser

55 60 65

gag?atc?ctc?tgg?gac?gca?gtc?acc?cag?gaa?ggt?gac?gga?tac?atc?aac 355

Glu?Ile?Leu?Trp?Asp?Ala?Val?Thr?Gln?Glu?Gly?Asp?Gly?Tyr?Ile?Asn

70 75 80 85

gcg?ctt?ggc?gca?ctc?acc?ggt?aac?cag?gct?gtt?cag?cag?gtt?cgt?gca 403

Ala?Leu?Gly?Ala?Leu?Thr?Gly?Asn?Gln?Ala?Val?Gln?Gln?Val?Arg?Ala

90 95 100

ggc?ctg?aag?gct?gtc?tac?ctg?tcc?ggt?tgg?cag?gtc?gca?ggt?gac?gcc 451

Gly?Leu?Lys?Ala?Val?Tyr?Leu?Ser?Gly?Trp?Gln?Val?Ala?Gly?Asp?Ala

105 110 115

aac?ctc?tcc?ggc?cac?acc?tac?cct?gac?cag?tcc?ctc?tac?cca?gcg?aac 499

Asn?Leu?Ser?Gly?His?Thr?Tyr?Pro?Asp?Gln?Ser?Leu?Tyr?Pro?Ala?Asn

120 125 130

tcc?gtt?cca?agc?gtc?gtt?cgt?cgc?atc?aac?aac?gca?ctg?ctg?cgt?tcc 547

Ser?Val?Pro?Ser?Val?Val?Arg?Arg?Ile?Asn?Asn?Ala?Leu?Leu?Arg?Ser

135 140 145

gat?gaa?atc?gca?cgc?acc?gaa?ggc?gac?acc?tcc?gtt?gac?aac?tgg?gtt 595

Asp?Glu?Ile?Ala?Arg?Thr?Glu?Gly?Asp?Thr?Ser?Val?Asp?Asn?Trp?Val

150 155 160 165

gtc?cca?atc?gtc?gcg?gac?ggc?gaa?gct?ggc?ttc?ggt?gga?gca?ctc?aac 643

Val?Pro?Ile?Val?Ala?Asp?Gly?Glu?Ala?Gly?Phe?Gly?Gly?Ala?Leu?Asn

170 175 180

gtc?tac?gaa?ctc?cag?aag?gca?atg?atc?gca?gct?ggc?gct?gca?ggc?acc 691

Val?Tyr?Glu?Leu?Gln?Lys?Ala?Met?Ile?Ala?Ala?Gly?Ala?Ala?Gly?Thr

185 190 195

cac?tgg?gaa?gac?cag?ctc?gct?tct?gaa?aag?aag?tgt?ggc?cac?ctc?ggc 739

His?Trp?Glu?Asp?Gln?Leu?Ala?Ser?Glu?Lys?Lys?Cys?Gly?His?Leu?Gly

200 205 210

ggc?aag?gtt?ctg?atc?cca?acc?cag?cag?cac?atc?cgc?acc?ctg?aac?tct 787

Gly?Lys?Val?Leu?Ile?Pro?Thr?Gln?Gln?His?Ile?Arg?Thr?Leu?Asn?Ser

215 220 225

gcc?cgc?ctt?gca?gca?gac?gtt?gca?aac?acc?cca?act?gtt?gtt?atc?gca 835

Ala?Arg?Leu?Ala?Ala?Asp?Val?Ala?Asn?Thr?Pro?Thr?Val?Val?Ile?Ala

230 235 240 245

cgt?acc?gac?gct?gag?gca?gca?acc?ctg?atc?acc?tct?gac?gtt?gat?gag 883

Arg?Thr?Asp?Ala?Glu?Ala?Ala?Thr?Leu?Ile?Thr?Ser?Asp?Val?Asp?Glu

250 255 260

cgc?gac?caa?cca?ttc?atc?acc?ggt?gag?cgc?acc?gca?gaa?ggc?tac?tac 931

Arg?Asp?Gln?Pro?Phe?Ile?Thr?Gly?Glu?Arg?Thr?Ala?Glu?Gly?Tyr?Tyr

265 270 275

cac?gtc?aag?aat?ggt?ctc?gag?cca?tgt?atc?gca?cgt?gca?aag?tcc?tac 979

His?Val?Lys?Asn?Gly?Leu?Glu?Pro?Cys?Ile?Ala?Arg?Ala?Lys?Ser?Tyr

280 285 290

gca?cca?tac?gca?gat?atg?atc?tgg?atg?gag?acc?ggc?acc?cct?gac?ctg 1027

Ala?Pro?Tyr?Ala?Asp?Met?Ile?Trp?Met?Glu?Thr?Gly?Thr?Pro?Asp?Leu

295 300 305

gag?ctc?gct?aag?aag?ttc?gct?gaa?ggc?gtt?cgc?tct?gag?ttc?cca?gac 1075

Glu?Leu?Ala?Lys?Lys?Phe?Ala?Glu?Gly?Val?Arg?Ser?Glu?Phe?Pro?Asp

310 315 320 325

cag?ctg?ctg?tcc?tac?aac?tgc?tcc?cca?tcc?ttc?aac?tgg?tct?gca?cac 1123

Gln?Leu?Leu?Ser?Tyr?Asn?Cys?Ser?Pro?Ser?Phe?Asn?Trp?Ser?Ala?His

330 335 340

ctc?gag?gca?gat?gag?atc?gct?aag?ttc?cag?aag?gaa?ctc?ggc?gca?atg 1171

Leu?Glu?Ala?Asp?Glu?Ile?Ala?Lys?Phe?Gln?Lys?Glu?Leu?Gly?Ala?Met

345 350 355

ggc?ttc?aag?ttc?cag?ttc?atc?acc?ctc?gca?ggc?ttc?cac?tcc?ctc?aac 1219

Gly?Phe?Lys?Phe?Gln?Phe?Ile?Thr?Leu?Ala?Gly?Phe?His?Ser?Leu?Asn

360 365 370

tac?ggc?atg?ttc?gac?ctg?gct?tac?gga?tac?gct?cgc?gaa?ggc?atg?acc 1267

Tyr?Gly?Met?Phe?Asp?Leu?Ala?Tyr?Gly?Tyr?Ala?Arg?Glu?Gly?Met?Thr

375 380 385

tcc?ttc?gtt?gac?ctg?cag?aac?cgt?gag?ttc?aag?gca?gct?gaa?gag?cgt 1315

Ser?Phe?Val?Asp?Leu?Gln?Asn?Arg?Glu?Phe?Lys?Ala?Ala?Glu?Glu?Arg

390 395 400 405

ggc?ttc?acc?gct?gtt?aag?cac?cag?cgt?gag?gtt?ggc?gca?ggc?tac?ttc 1363

Gly?Phe?Thr?Ala?Val?Lys?His?Gln?Arg?Glu?Val?Gly?Ala?Gly?Tyr?Phe

410 415 420

gac?cag?atc?gca?acc?acc?gtt?gac?ccg?aac?tct?tct?acc?acc?gct?ttg 1411

Asp?Gln?Ile?Ala?Thr?Thr?Val?Asp?Pro?Asn?Ser?Ser?Thr?Thr?Ala?Leu

425 430 435

aag?ggt?tcc?act?gaa?gaa?ggc?cag?ttc?cac?aac?taggacctac?aggttctgac?1464

Lys?Gly?Ser?Thr?Glu?Glu?Gly?Gln?Phe?His?Asn

440 445

aat 1467

<210>590

<211>448

<212>PRT

＜213〉Corynebacterium glutamicum

<400>590

Val?Val?Gly?Thr?Ala?His?Cys?Glu?Ser?Ala?Leu?Lys?Glu?Val?Thr?Leu

1 5 10 15

Met?Ser?Asn?Val?Gly?Lys?Pro?Arg?Thr?Ala?Gln?Glu?Ile?Gln?Gln?Asp

20 25 30

Trp?Asp?Thr?Asn?Pro?Arg?Trp?Asn?Gly?Ile?Thr?Arg?Asp?Tyr?Thr?Ala

35 40 45

Asp?Gln?Val?Ala?Asp?Leu?Gln?Gly?Ser?Val?Ile?Glu?Glu?His?Thr?Leu

50 55 60

Ala?Arg?Arg?Gly?Ser?Glu?Ile?Leu?Trp?Asp?Ala?Val?Thr?Gln?Glu?Gly

65 70 75 80

Asp?Gly?Tyr?Ile?Asn?Ala?Leu?Gly?Ala?Leu?Thr?Gly?Asn?Gln?Ala?Val

85 90 95

Gln?Gln?Val?Arg?Ala?Gly?Leu?Lys?Ala?Val?Tyr?Leu?Ser?Gly?Trp?Gln

100 105 110

Val?Ala?Gly?Asp?Ala?Asn?Leu?Ser?Gly?His?Thr?Tyr?Pro?Asp?Gln?Ser

115 120 125

Leu?Tyr?Pro?Ala?Asn?Ser?Val?Pro?Ser?Val?Val?Arg?Arg?Ile?Asn?Asn

130 135 140

Ala?Leu?Leu?Arg?Ser?Asp?Glu?Ile?Ala?Arg?Thr?Glu?Gly?Asp?Thr?Ser

145 150 155 160

Val?Asp?Asn?Trp?Val?Val?Pro?Ile?Val?Ala?Asp?Gly?Glu?Ala?Gly?Phe

165 170 175

Gly?Gly?Ala?Leu?Asn?Val?Tyr?Glu?Leu?Gln?Lys?Ala?Met?Ile?Ala?Ala

180 185 190

Gly?Ala?Ala?Gly?Thr?His?Trp?Glu?Asp?Gln?Leu?Ala?Ser?Glu?Lys?Lys

195 200 205

Cys?Gly?His?Leu?Gly?Gly?Lys?Val?Leu?Ile?Pro?Thr?Gln?Gln?His?Ile

210 215 220

Arg?Thr?Leu?Asn?Ser?Ala?Arg?Leu?Ala?Ala?Asp?Val?Ala?Asn?Thr?Pro

225 230 235 240

Thr?Val?Val?Ile?Ala?Arg?Thr?Asp?Ala?Glu?Ala?Ala?Thr?Leu?Ile?Thr

245 250 255

Ser?Asp?Val?Asp?Glu?Arg?Asp?Gln?Pro?Phe?Ile?Thr?Gly?Glu?Arg?Thr

260 265 270

Ala?Glu?Gly?Tyr?Tyr?His?Val?Lys?Asn?Gly?Leu?Glu?Pro?Cys?Ile?Ala

275 280 285

Arg?Ala?Lys?Ser?Tyr?Ala?Pro?Tyr?Ala?Asp?Met?Ile?Trp?Met?Glu?Thr

290 295 300

Gly?Thr?Pro?Asp?Leu?Glu?Leu?Ala?Lys?Lys?Phe?Ala?Glu?Gly?Val?Arg

305 310 315 320

Ser?Glu?Phe?Pro?Asp?Gln?Leu?Leu?Ser?Tyr?Asn?Cys?Ser?Pro?Ser?Phe

325 330 335

Asn?Trp?Ser?Ala?His?Leu?Glu?Ala?Asp?Glu?Ile?Ala?Lys?Phe?Gln?Lys

340 345 350

Glu?Leu?Gly?Ala?Met?Gly?Phe?Lys?Phe?Gln?Phe?Ile?Thr?Leu?Ala?Gly

355 360 365

Phe?His?Ser?Leu?Asn?Tyr?Gly?Met?Phe?Asp?Leu?Ala?Tyr?Gly?Tyr?Ala

370 375 380

Arg?Glu?Gly?Met?Thr?Ser?Phe?Val?Asp?Leu?Gln?Asn?Arg?Glu?Phe?Lys

385 390 395 400

Ala?Ala?Glu?Glu?Arg?Gly?Phe?Thr?Ala?Val?Lys?His?Gln?Arg?Glu?Val

405 410 415

Gly?Ala?Gly?Tyr?Phe?Asp?Gln?Ile?Ala?Thr?Thr?Val?Asp?Pro?Asn?Ser

420 425 430

Ser?Thr?Thr?Ala?Leu?Lys?Gly?Ser?Thr?Glu?Glu?Gly?Gln?Phe?His?Asn

435 440 445

<210>591

<211>1419

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1396)

<223>FRXA02399

<400>591

caaaccgatg?cacatcacgt?cgaaacagtg?acagtgcatt?agctcatact?ttgtggtcgg 60

caccgcccat?tgcgaatcag?cacttaagga?agtgactttg?atg?tca?aac?gtt?gga 115

Met?Ser?Asn?Val?Gly

1 5

aag?cca?cgt?acc?gca?cag?gaa?atc?cag?cag?gat?tgg?gac?acc?aac?cct 163

Lys?Pro?Arg?Thr?Ala?Gln?Glu?Ile?Gln?Gln?Asp?Trp?Asp?Thr?Asn?Pro

10 15 20

cgt?tgg?aac?ggc?atc?acc?cgc?gac?tac?acc?gca?gac?cag?gta?gct?gat 211

Arg?Trp?Asn?Gly?Ile?Thr?Arg?Asp?Tyr?Thr?Ala?Asp?Gln?Val?Ala?Asp

25 30 35

ctg?cag?ggt?tcc?gtc?atc?gag?gag?cac?act?ctt?gct?cgc?cgc?ggc?tca 259

Leu?Gln?Gly?Ser?Val?Ile?Glu?Glu?His?Thr?Leu?Ala?Arg?Arg?Gly?Ser

40 45 50

gag?atc?ctc?tgg?gac?gca?gtc?acc?cag?gaa?ggt?gac?gga?tac?atc?aac 307

Glu?Ile?Leu?Trp?Asp?Ala?Val?Thr?Gln?Glu?Gly?Asp?Gly?Tyr?Ile?Asn

55 60 65

gcg?ctt?ggc?gca?ctc?acc?ggt?aac?cag?gct?gtt?cag?cag?gtt?cgt?gca 355

Ala?Leu?Gly?Ala?Leu?Thr?Gly?Asn?Gln?Ala?Val?Gln?Gln?Val?Arg?Ala

70 75 80 85

ggc?ctg?aag?gct?gtc?tac?ctg?tcc?ggt?tgg?cag?gtc?gca?ggt?gac?gcc 403

Gly?Leu?Lys?Ala?Val?Tyr?Leu?Ser?Gly?Trp?Gln?Val?Ala?Gly?Asp?Ala

90 95 100

aac?ctc?tcc?ggc?cac?acc?tac?cct?gac?cag?tcc?ctc?tac?cca?gcg?aac 451

Asn?Leu?Ser?Gly?His?Thr?Tyr?Pro?Asp?Gln?Ser?Leu?Tyr?Pro?Ala?Asn

105 110 115

tcc?gtt?cca?agc?gtc?gtt?cgt?cgc?atc?aac?aac?gca?ctg?ctg?cgt?tcc 499

Ser?Val?Pro?Ser?Val?Val?Arg?Arg?Ile?Asn?Asn?Ala?Leu?Leu?Arg?Ser

120 125 130

gat?gaa?atc?gca?cgc?acc?gaa?ggc?gac?acc?tcc?gtt?gac?aac?tgg?gtt 547

Asp?Glu?Ile?Ala?Arg?Thr?Glu?Gly?Asp?Thr?Ser?Val?Asp?Asn?Trp?Val

135 140 145

gtc?cca?atc?gtc?gcg?gac?ggc?gaa?gct?ggc?ttc?ggt?gga?gca?ctc?aac 595

Val?Pro?Ile?Val?Ala?Asp?Gly?Glu?Ala?Gly?Phe?Gly?Gly?Ala?Leu?Asn

150 155 160 165

gtc?tac?gaa?ctc?cag?aag?gca?atg?atc?gca?gct?ggc?gct?gca?ggc?acc 643

Val?Tyr?Glu?Leu?Gln?Lys?Ala?Met?Ile?Ala?Ala?Gly?Ala?Ala?Gly?Thr

170 175 180

cac?tgg?gaa?gac?cag?ctc?gct?tct?gaa?aag?aag?tgt?ggc?cac?ctc?ggc 691

His?Trp?Glu?Asp?Gln?Leu?Ala?Ser?Glu?Lys?Lys?Cys?Gly?His?Leu?Gly

185 190 195

ggc?aag?gtt?ctg?atc?cca?acc?cag?cag?cac?atc?cgc?acc?ctg?aac?tct 739

Gly?Lys?Val?Leu?Ile?Pro?Thr?Gln?Gln?His?Ile?Arg?Thr?Leu?Asn?Ser

200 205 210

gcc?cgc?ctt?gca?gca?gac?gtt?gca?aac?acc?cca?act?gtt?gtt?atc?gca 787

Ala?Arg?Leu?Ala?Ala?Asp?Val?Ala?Asn?Thr?Pro?Thr?Val?Val?Ile?Ala

215 220 225

cgt?acc?gac?gct?gag?gca?gca?acc?ctg?atc?acc?tct?gac?gtt?gat?gag 835

Arg?Thr?Asp?Ala?Glu?Ala?Ala?Thr?Leu?Ile?Thr?Ser?Asp?Val?Asp?Glu

230 235 240 245

cgc?gac?caa?cca?ttc?atc?acc?ggt?gag?cgc?acc?gca?gaa?ggc?tac?tac 883

Arg?Asp?Gln?Pro?Phe?Ile?Thr?Gly?Glu?Arg?Thr?Ala?Glu?Gly?Tyr?Tyr

250 255 260

cac?gtc?aag?aat?ggt?ctc?gag?cca?tgt?atc?gca?cgt?gca?aag?tcc?tac 931

His?Val?Lys?Asn?Gly?Leu?Glu?Pro?Cys?Ile?Ala?Arg?Ala?Lys?Ser?Tyr

265 270 275

gca?cca?tac?gca?gat?atg?atc?tgg?atg?gag?acc?ggc?acc?cct?gac?ctg 979

Ala?Pro?Tyr?Ala?Asp?Met?Ile?Trp?Met?Glu?Thr?Gly?Thr?Pro?Asp?Leu

280 285 290

gag?ctc?gct?aag?aag?ttc?gct?gaa?ggc?gtt?cgc?tct?gag?ttc?cca?gac 1027

Glu?Leu?Ala?Lys?Lys?Phe?Ala?Glu?Gly?Val?Arg?Ser?Glu?Phe?Pro?Asp

295 300 305

cag?ctg?ctg?tcc?tac?aac?tgc?tcc?cca?tcc?ttc?aac?tgg?tct?gca?cac 1075

Gln?Leu?Leu?Ser?Tyr?Asn?Cys?Ser?Pro?Ser?Phe?Asn?Trp?Ser?Ala?His

310 315 320 325

ctc?gag?gca?gat?gag?atc?gct?aag?ttc?cag?aag?gaa?ctc?ggc?gca?atg 1123

Leu?Glu?Ala?Asp?Glu?Ile?Ala?Lys?Phe?Gln?Lys?Glu?Leu?Gly?Ala?Met

330 335 340

ggc?ttc?aag?ttc?cag?ttc?atc?acc?ctc?gca?ggc?ttc?cac?tcc?ctc?aac 1171

Gly?Phe?Lys?Phe?Gln?Phe?Ile?Thr?Leu?Ala?Gly?Phe?His?Ser?Leu?Asn

345 350 355

tac?ggc?atg?ttc?gac?ctg?gct?tac?gga?tac?gct?cgc?gaa?ggc?atg?acc 1219

Tyr?Gly?Met?Phe?Asp?Leu?Ala?Tyr?Gly?Tyr?Ala?Arg?Glu?Gly?Met?Thr

360 365 370

tcc?ttc?gtt?gac?ctg?cag?aac?cgt?gag?ttc?aag?gca?gct?gaa?gag?cgt 1267

Ser?Phe?Val?Asp?Leu?Gln?Asn?Arg?Glu?Phe?Lys?Ala?Ala?Glu?Glu?Arg

375 380 385

ggc?ttc?acc?gct?gtt?aag?cac?cag?cgt?gag?gtt?ggc?gca?ggc?tac?ttc 1315

Gly?Phe?Thr?Ala?Val?Lys?His?Gln?Arg?Glu?Val?Gly?Ala?Gly?Tyr?Phe

390 395 400 405

gac?cag?atc?gca?acc?acc?gtt?gac?ccg?aac?tct?tct?acc?acc?gct?ttg 1363

Asp?Gln?Ile?Ala?Thr?Thr?Val?Asp?Pro?Asn?Ser?Ser?Thr?Thr?Ala?Leu

410 415 420

aag?ggt?tcc?act?gaa?gaa?ggc?cag?ttc?cac?aac?taggacctac?aggttctgac?1416

Lys?Gly?Ser?Thr?Glu?Glu?Gly?Gln?Phe?His?Asn

425 430

aat 1419

<210>592

<211>432

<212>PRT

＜213〉Corynebacterium glutamicum

<400>592

Met?Ser?Asn?Val?Gly?Lys?Pro?Arg?Thr?Ala?Gln?Glu?Ile?Gln?Gln?Asp

1 5 10 15

Trp?Asp?Thr?Asn?Pro?Arg?Trp?Asn?Gly?Ile?Thr?Arg?Asp?Tyr?Thr?Ala

20 25 30

Asp?Gln?Val?Ala?Asp?Leu?Gln?Gly?Ser?Val?Ile?Glu?Glu?His?Thr?Leu

35 40 45

Ala?Arg?Arg?Gly?Ser?Glu?Ile?Leu?Trp?Asp?Ala?Val?Thr?Gln?Glu?Gly

50 55 60

Asp?Gly?Tyr?Ile?Asn?Ala?Leu?Gly?Ala?Leu?Thr?Gly?Asn?Gln?Ala?Val

65 70 75 80

Gln?Gln?Val?Arg?Ala?Gly?Leu?Lys?Ala?Val?Tyr?Leu?Ser?Gly?Trp?Gln

85 90 95

Val?Ala?Gly?Asp?Ala?Asn?Leu?Ser?Gly?His?Thr?Tyr?Pro?Asp?Gln?Ser

100 105 110

Leu?Tyr?Pro?Ala?Asn?Ser?Val?Pro?Ser?Val?Val?Arg?Arg?Ile?Asn?Asn

115 120 125

Ala?Leu?Leu?Arg?Ser?Asp?Glu?Ile?Ala?Arg?Thr?Glu?Gly?Asp?Thr?Ser

130 135 140

Val?Asp?Asn?Trp?Val?Val?Pro?Ile?Val?Ala?Asp?Gly?Glu?Ala?Gly?Phe

145 150 155 160

Gly?Gly?Ala?Leu?Asn?Val?Tyr?Glu?Leu?Gln?Lys?Ala?Met?Ile?Ala?Ala

165 170 175

Gly?Ala?Ala?Gly?Thr?His?Trp?Glu?Asp?Gln?Leu?Ala?Ser?Glu?Lys?Lys

180 185 190

Cys?Gly?His?Leu?Gly?Gly?Lys?Val?Leu?Ile?Pro?Thr?Gln?Gln?His?Ile

195 200 205

Arg?Thr?Leu?Asn?Ser?Ala?Arg?Leu?Ala?Ala?Asp?Val?Ala?Asn?Thr?Pro

210 215 220

Thr?Val?Val?Ile?Ala?Arg?Thr?Asp?Ala?Glu?Ala?Ala?Thr?Leu?Ile?Thr

225 230 235 240

Ser?Asp?Val?Asp?Glu?Arg?Asp?Gln?Pro?Phe?Ile?Thr?Gly?Glu?Arg?Thr

245 250 255

Ala?Glu?Gly?Tyr?Tyr?His?Val?Lys?Asn?Gly?Leu?Glu?Pro?Cys?Ile?Ala

260 265 270

Arg?Ala?Lys?Ser?Tyr?Ala?Pro?Tyr?Ala?Asp?Met?Ile?Trp?Met?Glu?Thr

275 280 285

Gly?Thr?Pro?Asp?Leu?Glu?Leu?Ala?Lys?Lys?Phe?Ala?Glu?Gly?Val?Arg

290 295 300

Ser?Glu?Phe?Pro?Asp?Gln?Leu?Leu?Ser?Tyr?Asn?Cys?Ser?Pro?Ser?Phe

305 310 315 320

Asn?Trp?Ser?Ala?His?Leu?Glu?Ala?Asp?Glu?Ile?Ala?Lys?Phe?Gln?Lys

325 330 335

Glu?Leu?Gly?Ala?Met?Gly?Phe?Lys?Phe?Gln?Phe?Ile?Thr?Leu?Ala?Gly

340 345 350

Phe?His?Ser?Leu?Asn?Tyr?Gly?Met?Phe?Asp?Leu?Ala?Tyr?Gly?Tyr?Ala

355 360 365

Arg?Glu?Gly?Met?Thr?Ser?Phe?Val?Asp?Leu?Gln?Asn?Arg?Glu?Phe?Lys

370 375 380

Ala?Ala?Glu?Glu?Arg?Gly?Phe?Thr?Ala?Val?Lys?His?Gln?Arg?Glu?Val

385 390 395 400

Gly?Ala?Gly?Tyr?Phe?Asp?Gln?Ile?Ala?Thr?Thr?Val?Asp?Pro?Asn?Ser

405 410 415

Ser?Thr?Thr?Ala?Leu?Lys?Gly?Ser?Thr?Glu?Glu?Gly?Gln?Phe?His?Asn

420 425 430

<210>593

<211>2340

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(2317)

<223>RXN02404

<400>593

gttttcacaa?ccgttaacgg?cgtagccaaa?caagaaggat?tcgcattctt?ctggtttagg 60

cacaggtcat?ctaaaaccca?tgctttaaaa?ggagccttca?atg?act?gaa?cag?gaa 115

Met?Thr?Glu?Gln?Glu

1 5

ctg?ttg?tct?gct?cag?act?gcc?gac?aac?gct?gga?act?gac?agc?acc?gaa 163

Leu?Leu?Ser?Ala?Gln?Thr?Ala?Asp?Asn?Ala?Gly?Thr?Asp?Ser?Thr?Glu

10 15 20

cgc?gtt?gac?gcg?ggc?gga?atg?cag?gtt?gca?aaa?gtt?ctc?tac?gac?ttt 211

Arg?Val?Asp?Ala?Gly?Gly?Met?Gln?Val?Ala?Lys?Val?Leu?Tyr?Asp?Phe

25 30 35

gta?acc?gaa?gcg?gta?ctc?cct?cgc?gtg?ggt?gtg?gat?gcg?gaa?aag?ttc 259

Val?Thr?Glu?Ala?Val?Leu?Pro?Arg?Val?Gly?Val?Asp?Ala?Glu?Lys?Phe

40 45 50

tgg?tcc?gga?ttc?gcc?gcc?atc?gcc?cgg?gac?ctc?acc?cca?cgc?aac?cgc 307

Trp?Ser?Gly?Phe?Ala?Ala?Ile?Ala?Arg?Asp?Leu?Thr?Pro?Arg?Asn?Arg

55 60 65

gag?ctg?ctt?gct?cgc?cgc?gat?gaa?ctg?cag?atg?ctt?atc?gac?gac?tac 355

Glu?Leu?Leu?Ala?Arg?Arg?Asp?Glu?Leu?Gln?Met?Leu?Ile?Asp?Asp?Tyr

70 75 80 85

cac?cgc?aac?aac?tcc?ggc?acc?atc?gac?caa?gag?gcg?tac?gag?gat?ttc 403

His?Arg?Asn?Asn?Ser?Gly?Thr?Ile?Asp?Gln?Glu?Ala?Tyr?Glu?Asp?Phe

90 95 100

ctc?aaa?gaa?atc?gga?tac?ttg?gtt?gag?gag?cca?gaa?gct?gca?gaa?atc 451

Leu?Lys?Glu?Ile?Gly?Tyr?Leu?Val?Glu?Glu?Pro?Glu?Ala?Ala?Glu?Ile

105 110 115

cgt?acc?caa?aac?gtc?gat?acg?gaa?atc?tcc?agc?acc?gca?gga?cct?cag 499

Arg?Thr?Gln?Asn?Val?Asp?Thr?Glu?Ile?Ser?Ser?Thr?Ala?Gly?Pro?Gln

120 125 130

ctg?gtt?gtt?cca?att?ctg?aac?gca?cgc?ttc?gcg?ctg?aac?gct?gcc?aat 547

Leu?Val?Val?Pro?Ile?Leu?Asn?Ala?Arg?Phe?Ala?Leu?Asn?Ala?Ala?Asn

135 140 145

gct?cgc?tgg?ggt?tcc?ctc?tac?gat?gcg?ttg?tac?ggc?acc?aac?gcc?atc 595

Ala?Arg?Trp?Gly?Ser?Leu?Tyr?Asp?Ala?Leu?Tyr?Gly?Thr?Asn?Ala?Ile

150 155 160 165

cca?gaa?act?gat?ggc?gct?gaa?aag?ggc?aag?gag?tac?aac?ccg?gtc?cgc 643

Pro?Glu?Thr?Asp?Gly?Ala?Glu?Lys?Gly?Lys?Glu?Tyr?Asn?Pro?Val?Arg

170 175 180

ggc?cag?aag?gtc?atc?gag?tgg?ggt?cgt?gaa?ttc?ctc?gac?agc?gtt?gtc 691

Gly?Gln?Lys?Val?Ile?Glu?Trp?Gly?Arg?Glu?Phe?Leu?Asp?Ser?Val?Val

185 190 195

cca?ctg?gac?ggt?gct?tcg?cat?gcc?gat?gtt?gag?aag?tac?aac?atc?acc 739

Pro?Leu?Asp?Gly?Ala?Ser?His?Ala?Asp?Val?Glu?Lys?Tyr?Asn?Ile?Thr

200 205 210

gat?gga?aag?ctt?gca?gcc?cac?att?gga?gat?agc?gtc?tac?cga?ctg?aaa 787

Asp?Gly?Lys?Leu?Ala?Ala?His?Ile?Gly?Asp?Ser?Val?Tyr?Arg?Leu?Lys

215 220 225

aac?cgt?gaa?tcc?tac?cgt?ggc?ttc?acc?ggc?aac?ttc?ctt?gat?cca?gaa 835

Asn?Arg?Glu?Ser?Tyr?Arg?Gly?Phe?Thr?Gly?Asn?Phe?Leu?Asp?Pro?Glu

230 235 240 245

gca?atc?ctg?ctg?gaa?acc?aac?ggc?ctg?cac?atc?gag?ctg?cag?atc?gat 883

Ala?Ile?Leu?Leu?Glu?Thr?Asn?Gly?Leu?His?Ile?Glu?Leu?Gln?Ile?Asp

250 255 260

cct?gtc?cac?cca?atc?ggc?aag?gca?gac?aag?act?ggt?ctc?aaa?gac?atc 931

Pro?Val?His?Pro?Ile?Gly?Lys?Ala?Asp?Lys?Thr?Gly?Leu?Lys?Asp?Ile

265 270 275

gtt?ttg?gaa?tct?gcg?atc?acc?acg?atc?atg?gac?ttc?gaa?gac?tcc?gtt 979

Val?Leu?Glu?Ser?Ala?Ile?Thr?Thr?Ile?Met?Asp?Phe?Glu?Asp?Ser?Val

280 285 290

gca?gct?gtt?gat?gct?gaa?gac?aag?acc?tta?ggt?tac?tct?aac?tgg?ttc 1027

Ala?Ala?Val?Asp?Ala?Glu?Asp?Lys?Thr?Leu?Gly?Tyr?Ser?Asn?Trp?Phe

295 300 305

gga?ctc?aac?acc?ggc?gaa?ctg?aaa?gaa?gag?atg?tcc?aag?aac?gga?cgc 1075

Gly?Leu?Asn?Thr?Gly?Glu?Leu?Lys?Glu?Glu?Met?Ser?Lys?Asn?Gly?Arg

310 315 320 325

atc?ttc?acc?cgt?gag?ctc?aac?aag?gac?cgc?gtc?tac?att?ggc?cgc?aat 1123

Ile?Phe?Thr?Arg?Glu?Leu?Asn?Lys?Asp?Arg?Val?Tyr?Ile?Gly?Arg?Asn

330 335 340

ggt?acc?gag?ctg?gtt?ctg?cac?ggt?cgt?tcc?ctg?ctg?ttc?gtc?cgc?aac 1171

Gly?Thr?Glu?Leu?Val?Leu?His?Gly?Arg?Ser?Leu?Leu?Phe?Val?Arg?Asn

345 350 355

gtt?ggt?cac?ctc?atg?caa?aac?cca?tcc?atc?ttg?att?gat?ggc?gag?gag 1219

Val?Gly?His?Leu?Met?Gln?Asn?Pro?Ser?Ile?Leu?Ile?Asp?Gly?Glu?Glu

360 365 370

atc?ttc?gaa?ggc?atc?atg?gat?gct?gtc?ttg?acc?act?gtt?tgt?gcc?atc 1267

Ile?Phe?Glu?Gly?Ile?Met?Asp?Ala?Val?Leu?Thr?Thr?Val?Cys?Ala?Ile

375 380 385

cca?gga?att?gct?ccg?cag?aac?aag?atg?cgc?aat?tcc?cgc?aag?ggc?tcc 1315

Pro?Gly?Ile?Ala?Pro?Gln?Asn?Lys?Met?Arg?Asn?Ser?Arg?Lys?Gly?Ser

390 395 400 405

atc?tac?atc?gtg?aag?cct?aag?cag?cac?ggc?cct?gaa?gaa?gtc?gcg?ttc 1363

Ile?Tyr?Ile?Val?Lys?Pro?Lys?Gln?His?Gly?Pro?Glu?Glu?Val?Ala?Phe

410 415 420

acc?aac?gag?ctc?ttc?ggc?cgc?gtt?gag?gat?ctg?ctt?gat?ctg?cca?cgc 1411

Thr?Asn?Glu?Leu?Phe?Gly?Arg?Val?Glu?Asp?Leu?Leu?Asp?Leu?Pro?Arg

425 430 435

cac?acc?ttg?aag?gtt?ggt?gtt?atg?gat?gag?gag?cgt?cgc?acg?tcc?gtg 1459

His?Thr?Leu?Lys?Val?Gly?Val?Met?Asp?Glu?Glu?Arg?Arg?Thr?Ser?Val

440 445 450

aac?ctg?gat?gcc?agc?atc?atg?gaa?gtt?gct?gac?cgc?ttg?gca?ttc?atc 1507

Asn?Leu?Asp?Ala?Ser?Ile?Met?Glu?Val?Ala?Asp?Arg?Leu?Ala?Phe?Ile

455 460 465

aac?act?ggc?ttc?ctg?gac?cgc?acc?ggc?gat?gaa?atc?cac?acc?tcc?atg 1555

Asn?Thr?Gly?Phe?Leu?Asp?Arg?Thr?Gly?Asp?Glu?Ile?His?Thr?Ser?Met

470 475 480 485

gaa?gca?ggc?gcc?atg?gtg?cgc?aag?gct?gat?atg?cag?acc?gca?ccg?tgg 1603

Glu?Ala?Gly?Ala?Met?Val?Arg?Lys?Ala?Asp?Met?Gln?Thr?Ala?Pro?Trp

490 495 500

aag?cag?gcc?tac?gag?aac?aac?aac?gtt?gat?gca?ggt?att?cag?cgt?ggt 1651

Lys?Gln?Ala?Tyr?Glu?Asn?Asn?Asn?Val?Asp?Ala?Gly?Ile?Gln?Arg?Gly

505 510 515

ctt?cct?ggc?aag?gct?cag?atc?ggt?aag?ggc?atg?tgg?gcg?atg?act?gaa 1699

Leu?Pro?Gly?Lys?Ala?Gln?Ile?Gly?Lys?Gly?Met?Trp?Ala?Met?Thr?Glu

520 525 530

ctc?atg?gca?gaa?atg?ctg?gag?aag?aag?atc?ggc?cag?cca?cgc?gaa?ggc 1747

Leu?Met?Ala?Glu?Met?Leu?Glu?Lys?Lys?Ile?Gly?Gln?Pro?Arg?Glu?Gly

535 540 545

gcc?aac?act?gca?tgg?gtt?cct?tca?cca?act?ggt?gcg?acg?ctg?cac?gca 1795

Ala?Asn?Thr?Ala?Trp?Val?Pro?Ser?Pro?Thr?Gly?Ala?Thr?Leu?His?Ala

550 555 560 565

acg?cac?tac?cac?ttg?gtt?gat?gtg?ttc?aag?gtt?caa?gac?gaa?ctg?cgt 1843

Thr?His?Tyr?His?Leu?Val?Asp?Val?Phe?Lys?Val?Gln?Asp?Glu?Leu?Arg

570 575 580

gct?gcc?ggc?cgc?cgc?gac?agc?ctg?cgc?aac?att?ctc?acc?att?tca?acc 1891

Ala?Ala?Gly?Arg?Arg?Asp?Ser?Leu?Arg?Asn?Ile?Leu?Thr?Ile?Ser?Thr

585 590 595

gca?cca?aac?acc?aat?tgg?tct?gag?gaa?gag?aag?aag?gaa?gag?atg?gac 1939

Ala?Pro?Asn?Thr?Asn?Trp?Ser?Glu?Glu?Glu?Lys?Lys?Glu?Glu?Met?Asp

600 605 610

aac?aac?tgc?cag?tcc?atc?ctc?gga?tac?gtt?gtg?cgc?tgg?gtt?gag?cac 1987

Asn?Asn?Cys?Gln?Ser?Ile?Leu?Gly?Tyr?Val?Val?Arg?Trp?Val?Glu?His

615 620 625

ggt?gtt?ggt?tgc?tcc?aag?gtt?cca?gac?atc?cat?gac?atc?gac?ctc?atg 2035

Gly?Val?Gly?Cys?Ser?Lys?Val?Pro?Asp?Ile?His?Asp?Ile?Asp?Leu?Met

630 635 640 645

gaa?gac?cgc?gca?acg?ctg?cgt?att?tcc?tcg?cag?atg?ctg?gcc?aac?tgg 2083

Glu?Asp?Arg?Ala?Thr?Leu?Arg?Ile?Ser?Ser?Gln?Met?Leu?Ala?Asn?Trp

650 655 660

atc?cgc?cat?gat?gtt?gtc?tcg?aag?gag?cag?gtc?ttg?gag?tca?ctg?gaa 2131

Ile?Arg?His?Asp?Val?Val?Ser?Lys?Glu?Gln?Val?Leu?Glu?Ser?Leu?Glu

665 670 675

cga?atg?gca?gtg?gtc?gtc?gac?aag?caa?aat?gcg?ggc?gac?gag?gcc?tac 2179

Arg?Met?Ala?Val?Val?Val?Asp?Lys?Gln?Asn?Ala?Gly?Asp?Glu?Ala?Tyr

680 685 690

cgc?gat?atg?gcg?ccg?aag?tac?gac?gcc?tcc?ctc?gcc?ttc?cag?gcg?gct 2227

Arg?Asp?Met?Ala?Pro?Lys?Tyr?Asp?Ala?Ser?Leu?Ala?Phe?Gln?Ala?Ala

695 700 705

aag?gac?ttg?att?ttc?gaa?ggc?acc?aag?tcc?cca?tcg?ggc?tac?acc?gag 2275

Lys?Asp?Leu?Ile?Phe?Glu?Gly?Thr?Lys?Ser?Pro?Ser?Gly?Tyr?Thr?Glu

710 715 720 725

ccc?atc?ttg?cac?gca?cgc?cgc?cgc?gag?ttc?aaa?gca?aaa?aac 2317

Pro?Ile?Leu?His?Ala?Arg?Arg?Arg?Glu?Phe?Lys?Ala?Lys?Asn

730 735

taagcacgct?tttcgacgct?tac 2340

<210>594

<211>739

<212>PRT

＜213〉Corynebacterium glutamicum

<400>594

Met?Thr?Glu?Gln?Glu?Leu?Leu?Ser?Ala?Gln?Thr?Ala?Asp?Asn?Ala?Gly

1 5 10 15

Thr?Asp?Ser?Thr?Glu?Arg?Val?Asp?Ala?Gly?Gly?Met?Gln?Val?Ala?Lys

20 25 30

Val?Leu?Tyr?Asp?Phe?Val?Thr?Glu?Ala?Val?Leu?Pro?Arg?Val?Gly?Val

35 40 45

Asp?Ala?Glu?Lys?Phe?Trp?Ser?Gly?Phe?Ala?Ala?Ile?Ala?Arg?Asp?Leu

50 55 60

Thr?Pro?Arg?Asn?Arg?Glu?Leu?Leu?Ala?Arg?Arg?Asp?Glu?Leu?Gln?Met

65 70 75 80

Leu?Ile?Asp?Asp?Tyr?His?Arg?Asn?Asn?Ser?Gly?Thr?Ile?Asp?Gln?Glu

85 90 95

Ala?Tyr?Glu?Asp?Phe?Leu?Lys?Glu?Ile?Gly?Tyr?Leu?Val?Glu?Glu?Pro

100 105 110

Glu?Ala?Ala?Glu?Ile?Arg?Thr?Gln?Asn?Val?Asp?Thr?Glu?Ile?Ser?Ser

115 120 125

Thr?Ala?Gly?Pro?Gln?Leu?Val?Val?Pro?Ile?Leu?Asn?Ala?Arg?Phe?Ala

130 135 140

Leu?Asn?Ala?Ala?Asn?Ala?Arg?Trp?Gly?Ser?Leu?Tyr?Asp?Ala?Leu?Tyr

145 150 155 160

Gly?Thr?Asn?Ala?Ile?Pro?Glu?Thr?Asp?Gly?Ala?Glu?Lys?Gly?Lys?Glu

165 170 175

Tyr?Asn?Pro?Val?Arg?Gly?Gln?Lys?Val?Ile?Glu?Trp?Gly?Arg?Glu?Phe

180 185 190

Leu?Asp?Ser?Val?Val?Pro?Leu?Asp?Gly?Ala?Ser?His?Ala?Asp?Val?Glu

195 200 205

Lys?Tyr?Asn?Ile?Thr?Asp?Gly?Lys?Leu?Ala?Ala?His?Ile?Gly?Asp?Ser

210 215 220

Val?Tyr?Arg?Leu?Lys?Asn?Arg?Glu?Ser?Tyr?Arg?Gly?Phe?Thr?Gly?Asn

225 230 235 240

Phe?Leu?Asp?Pro?Glu?Ala?Ile?Leu?Leu?Glu?Thr?Asn?Gly?Leu?His?Ile

245 250 255

Glu?Leu?Gln?Ile?Asp?Pro?Val?His?Pro?Ile?Gly?Lys?Ala?Asp?Lys?Thr

260 265 270

Gly?Leu?Lys?Asp?Ile?Val?Leu?Glu?Ser?Ala?Ile?Thr?Thr?Ile?Met?Asp

275 280 285

Phe?Glu?Asp?Ser?Val?Ala?Ala?Val?Asp?Ala?Glu?Asp?Lys?Thr?Leu?Gly

290 295 300

Tyr?Ser?Asn?Trp?Phe?Gly?Leu?Asn?Thr?Gly?Glu?Leu?Lys?Glu?Glu?Met

305 310 315 320

Ser?Lys?Asn?Gly?Arg?Ile?Phe?Thr?Arg?Glu?Leu?Asn?Lys?Asp?Arg?Val

325 330 335

Tyr?Ile?Gly?Arg?Asn?Gly?Thr?Glu?Leu?Val?Leu?His?Gly?Arg?Ser?Leu

340 345 350

Leu?Phe?Val?Arg?Asn?Val?Gly?His?Leu?Met?Gln?Asn?Pro?Ser?Ile?Leu

355 360 365

Ile?Asp?Gly?Glu?Glu?Ile?Phe?Glu?Gly?Ile?Met?Asp?Ala?Val?Leu?Thr

370 375 380

Thr?Val?Cys?Ala?Ile?Pro?Gly?Ile?Ala?Pro?Gln?Asn?Lys?Met?Arg?Asn

385 390 395 400

Ser?Arg?Lys?Gly?Ser?Ile?Tyr?Ile?Val?Lys?Pro?Lys?Gln?His?Gly?Pro

405 410 415

Glu?Glu?Val?Ala?Phe?Thr?Asn?Glu?Leu?Phe?Gly?Arg?Val?Glu?Asp?Leu

420 425 430

Leu?Asp?Leu?Pro?Arg?His?Thr?Leu?Lys?Val?Gly?Val?Met?Asp?Glu?Glu

435 440 445

Arg?Arg?Thr?Ser?Val?Asn?Leu?Asp?Ala?Ser?Ile?Met?Glu?Val?Ala?Asp

450 455 460

Arg?Leu?Ala?Phe?Ile?Asn?Thr?Gly?Phe?Leu?Asp?Arg?Thr?Gly?Asp?Glu

465 470 475 480

Ile?His?Thr?Ser?Met?Glu?Ala?Gly?Ala?Met?Val?Arg?Lys?Ala?Asp?Met

485 490 495

Gln?Thr?Ala?Pro?Trp?Lys?Gln?Ala?Tyr?Glu?Asn?Asn?Asn?Val?Asp?Ala

500 505 510

Gly?Ile?Gln?Arg?Gly?Leu?Pro?Gly?Lys?Ala?Gln?Ile?Gly?Lys?Gly?Met

515 520 525

Trp?Ala?Met?Thr?Glu?Leu?Met?Ala?Glu?Met?Leu?Glu?Lys?Lys?Ile?Gly

530 535 540

Gln?Pro?Arg?Glu?Gly?Ala?Asn?Thr?Ala?Trp?Val?Pro?Ser?Pro?Thr?Gly

545 550 555 560

Ala?Thr?Leu?His?Ala?Thr?His?Tyr?His?Leu?Val?Asp?Val?Phe?Lys?Val

565 570 575

Gln?Asp?Glu?Leu?Arg?Ala?Ala?Gly?Arg?Arg?Asp?Ser?Leu?Arg?Asn?Ile

580 585 590

Leu?Thr?Ile?Ser?Thr?Ala?Pro?Asn?Thr?Asn?Trp?Ser?Glu?Glu?Glu?Lys

595 600 605

Lys?Glu?Glu?Met?Asp?Asn?Asn?Cys?Gln?Ser?Ile?Leu?Gly?Tyr?ValVal

610 615 620

Arg?Trp?Val?Glu?His?Gly?Val?Gly?Cys?Ser?Lys?Val?Pro?Asp?Ile?His

625 630 635 640

Asp?Ile?Asp?Leu?Met?Glu?Asp?Arg?Ala?Thr?Leu?Arg?Ile?Ser?Ser?Gln

645 650 655

Met?Leu?Ala?Asn?Trp?Ile?Arg?His?Asp?Val?Val?Ser?Lys?Glu?Gln?Val

660 665 670

Leu?Glu?Ser?Leu?Glu?Arg?Met?Ala?Val?Val?Val?Asp?Lys?Gln?Asn?Ala

675 680 685

Gly?Asp?Glu?Ala?Tyr?Arg?Asp?Met?Ala?Pro?Lys?Tyr?Asp?Ala?Ser?Leu

690 695 700

Ala?Phe?Gln?Ala?Ala?Lys?Asp?Leu?Ile?Phe?Glu?Gly?Thr?Lys?Ser?Pro

705 710 715 720

Ser?Gly?Tyr?Thr?Glu?Pro?Ile?Leu?His?Ala?Arg?Arg?Arg?Glu?Phe?Lys

725 730 735

Ala?Lys?Asn

<210>595

<211>2159

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(2136)

<223>FRXA02404

<400>595

atg?cag?gtt?gca?aaa?gtt?ctc?tac?gac?ttt?gta?acc?gaa?gcg?gta?ctc 48

Met?Gln?Val?Ala?Lys?Val?Leu?Tyr?Asp?Phe?Val?Thr?Glu?Ala?Val?Leu

1 5 10 15

cct?cgc?gtg?ggt?gtg?gat?gcg?gaa?aag?ttc?tgg?tcc?gga?ttc?gcc?gcc 96

Pro?Arg?Val?Gly?Val?Asp?Ala?Glu?Lys?Phe?Trp?Ser?Gly?Phe?Ala?Ala

20 25 30

atc?gcc?cgg?gac?ctc?acc?cca?cgc?aac?cgc?gag?ctg?ctt?gct?cgc?cgc 144

Ile?Ala?Arg?Asp?Leu?Thr?Pro?Arg?Asn?Arg?Glu?Leu?Leu?Ala?Arg?Arg

35 40 45

gat?gaa?ctg?cag?atg?ctt?atc?gac?gac?tac?cac?cgc?aac?aac?tcc?ggc 192

Asp?Glu?Leu?Gln?Met?Leu?Ile?Asp?Asp?Tyr?His?Arg?Asn?Asn?Ser?Gly

50 55 60

acc?atc?gac?caa?gag?gcg?tac?gag?gat?ttc?ctc?aaa?gaa?atc?gga?tac 240

Thr?Ile?Asp?Gln?Glu?Ala?Tyr?Glu?Asp?Phe?Leu?Lys?Glu?Ile?Gly?Tyr

65 70 75 80

ttg?gtt?gag?gag?cca?gaa?gct?gca?gaa?atc?cgt?acc?caa?aac?gtc?gat 288

Leu?Val?Glu?Glu?Pro?Glu?Ala?Ala?Glu?Ile?Arg?Thr?Gln?Asn?Val?Asp

85 90 95

acg?gaa?atc?tcc?agc?acc?gca?gga?cct?cag?ctg?gtt?gtt?cca?att?ctg 336

Thr?Glu?Ile?Ser?Ser?Thr?Ala?Gly?Pro?Gln?Leu?Val?Val?Pro?Ile?Leu

100 105 110

aac?gca?cgc?ttc?gcg?ctg?aac?gct?gcc?aat?gct?cgc?tgg?ggt?tcc?ctc 384

Asn?Ala?Arg?Phe?Ala?Leu?Asn?Ala?Ala?Asn?Ala?Arg?Trp?Gly?Ser?Leu

115 120 125

tac?gat?gcg?ttg?tac?ggc?acc?aac?gcc?atc?cca?gaa?act?gat?ggc?gct 432

Tyr?Asp?Ala?Leu?Tyr?Gly?Thr?Asn?Ala?Ile?Pro?Glu?Thr?Asp?Gly?Ala

130 135 140

gaa?aag?ggc?aag?gag?tac?aac?ccg?gtc?cgc?ggc?cag?aag?gtc?atc?gag 480

Glu?Lys?Gly?Lys?Glu?Tyr?Asn?Pro?Val?Arg?Gly?Gln?Lys?Val?Ile?Glu

145 150 155 160

tgg?ggt?cgt?gaa?ttc?ctc?gac?agc?gtt?gtc?cca?ctg?gac?ggt?gct?tcg 528

Trp?Gly?Arg?Glu?Phe?Leu?Asp?Ser?Val?Val?Pro?Leu?Asp?Gly?Ala?Ser

165 170 175

cat?gcc?gat?gtt?gag?aag?tac?aac?atc?acc?gat?gga?aag?ctt?gca?gcc 576

His?Ala?Asp?Val?Glu?Lys?Tyr?Asn?Ile?Thr?Asp?Gly?Lys?Leu?Ala?Ala

180 185 190

cac?att?gga?gat?agc?gtc?tac?cga?ctg?aaa?aac?cgt?gaa?tcc?tac?cgt 624

His?Ile?Gly?Asp?Ser?Val?Tyr?Arg?Leu?Lys?Asn?Arg?Glu?Ser?Tyr?Arg

195 200 205

ggc?ttc?acc?ggc?aac?ttc?ctt?gat?cca?gaa?gca?atc?ctg?ctg?gaa?acc 672

Gly?Phe?Thr?Gly?Asn?Phe?Leu?Asp?Pro?Glu?Ala?Ile?Leu?Leu?Glu?Thr

210 215 220

aac?ggc?ctg?cac?atc?gag?ctg?cag?atc?gat?cct?gtc?cac?cca?atc?ggc 720

Asn?Gly?Leu?His?Ile?Glu?Leu?Gln?Ile?Asp?Pro?Val?His?Pro?Ile?Gly

225 230 235 240

aag?gca?gac?aag?act?ggt?ctc?aaa?gac?atc?gtt?ttg?gaa?tct?gcg?atc 768

Lys?Ala?Asp?Lys?Thr?Gly?Leu?Lys?Asp?Ile?Val?Leu?Glu?Ser?Ala?Ile

245 250 255

acc?acg?atc?atg?gac?ttc?gaa?gac?tcc?gtt?gca?gct?gtt?gat?gct?gaa 816

Thr?Thr?Ile?Met?Asp?Phe?Glu?Asp?Ser?Val?Ala?Ala?Val?Asp?Ala?Glu

260 265 270

gac?aag?acc?tta?ggt?tac?tct?aac?tgg?ttc?gga?ctc?aac?acc?ggc?gaa 864

Asp?Lys?Thr?Leu?Gly?Tyr?Ser?Asn?Trp?Phe?Gly?Leu?Asn?Thr?Gly?Glu

275 280 285

ctg?aaa?gaa?gag?atg?tcc?aag?aac?gga?cgc?atc?ttc?acc?cgt?gag?ctc 912

Leu?Lys?Glu?Glu?Met?Ser?Lys?Asn?Gly?Arg?Ile?Phe?Thr?Arg?Glu?Leu

290 295 300

aac?aag?gac?cgc?gtc?tac?att?ggc?cgc?aat?ggt?acc?gag?ctg?gtt?ctg 960

Asn?Lys?Asp?Arg?Val?Tyr?Ile?Gly?Arg?Asn?Gly?Thr?Glu?Leu?Val?Leu

305 310 315 320

cac?ggt?cgt?tcc?ctg?ctg?ttc?gtc?cgc?aac?gtt?ggt?cac?ctc?atg?caa 1008

His?Gly?Arg?Ser?Leu?Leu?Phe?Val?Arg?Asn?Val?Gly?His?Leu?Met?Gln

325 330 335

aac?cca?tcc?atc?ttg?att?gat?ggc?gag?gag?atc?ttc?gaa?ggc?atc?atg 1056

Asn?Pro?Ser?Ile?Leu?Ile?Asp?Gly?Glu?Glu?Ile?Phe?Glu?Gly?Ile?Met

340 345 350

gat?gct?gtc?ttg?acc?act?gtt?tgt?gcc?atc?cca?gga?att?gct?ccg?cag 1104

Asp?Ala?Val?Leu?Thr?Thr?Val?Cys?Ala?Ile?Pro?Gly?Ile?Ala?Pro?Gln

355 360 365

aac?aag?atg?cgc?aat?tcc?cgc?aag?ggc?tcc?atc?tac?atc?gtg?aag?cct 1152

Asn?Lys?Met?Arg?Asn?Ser?Arg?Lys?Gly?Ser?Ile?Tyr?Ile?Val?Lys?Pro

370 375 380

aag?cag?cac?ggc?cct?gaa?gaa?gtc?gcg?ttc?acc?aac?gag?ctc?ttc?ggc 1200

Lys?Gln?His?Gly?Pro?Glu?Glu?Val?Ala?Phe?Thr?Asn?Glu?Leu?Phe?Gly

385 390 395 400

cgc?gtt?gag?gat?ctg?ctt?gat?ctg?cca?cgc?cac?acc?ttg?aag?gtt?ggt 1248

Arg?Val?Glu?Asp?Leu?Leu?Asp?Leu?Pro?Arg?His?Thr?Leu?Lys?Val?Gly

405 410 415

gtt?atg?gat?gag?gag?cgt?cgc?acg?tcc?gtg?aac?ctg?gat?gcc?agc?atc 1296

Val?Met?Asp?Glu?Glu?Arg?Arg?Thr?Ser?Val?Asn?Leu?Asp?Ala?Ser?Ile

420 425 430

atg?gaa?gtt?gct?gac?cgc?ttg?gca?ttc?atc?aac?act?ggc?ttc?ctg?gac 1344

Met?Glu?Val?Ala?Asp?Arg?Leu?Ala?Phe?Ile?Asn?Thr?Gly?Phe?Leu?Asp

435 440 445

cgc?acc?ggc?gat?gaa?atc?cac?acc?tcc?atg?gaa?gca?ggc?gcc?atg?gtg 1392

Arg?Thr?Gly?Asp?Glu?Ile?His?Thr?Ser?Met?Glu?Ala?Gly?Ala?Met?Val

450 455 460

cgc?aag?gct?gat?atg?cag?acc?gca?ccg?tgg?aag?cag?gcc?tac?gag?aac 1440

Arg?Lys?Ala?Asp?Met?Gln?Thr?Ala?Pro?Trp?Lys?Gln?Ala?Tyr?Glu?Asn

465 470 475 480

aac?aac?gtt?gat?gca?ggt?att?cag?cgt?ggt?ctt?cct?ggc?aag?gct?cag 1488

Asn?Asn?Val?Asp?Ala?Gly?Ile?Gln?Arg?Gly?Leu?Pro?Gly?Lys?Ala?Gln

485 490 495

atc?ggt?aag?ggc?atg?tgg?gcg?atg?act?gaa?ctc?atg?gca?gaa?atg?ctg 1536

Ile?Gly?Lys?Gly?Met?Trp?Ala?Met?Thr?Glu?Leu?Met?Ala?Glu?Met?Leu

500 505 510

gag?aag?aag?atc?ggc?cag?cca?cgc?gaa?ggc?gcc?aac?act?gca?tgg?gtt 1584

Glu?Lys?Lys?Ile?Gly?Gln?Pro?Arg?Glu?Gly?Ala?Asn?Thr?Ala?Trp?Val

515 520 525

cct?tca?cca?act?ggt?gcg?acg?ctg?cac?gca?acg?cac?tac?cac?ttg?gtt 1632

Pro?Ser?Pro?Thr?Gly?Ala?Thr?Leu?His?Ala?Thr?His?Tyr?His?Leu?Val

530 535 540

gat?gtg?ttc?aag?gtt?caa?gac?gaa?ctg?cgt?gct?gcc?ggc?cgc?cgc?gac 1680

Asp?Val?Phe?Lys?Val?Gln?Asp?Glu?Leu?Arg?Ala?Ala?Gly?Arg?Arg?Asp

545 550 555 560

agc?ctg?cgc?aac?att?ctc?acc?att?tca?acc?gca?cca?aac?acc?aat?tgg 1728

Ser?Leu?Arg?Asn?Ile?Leu?Thr?Ile?Ser?Thr?Ala?Pro?Asn?Thr?Asn?Trp

565 570 575

tct?gag?gaa?gag?aag?aag?gaa?gag?atg?gac?aac?aac?tgc?cag?tcc?atc 1776

Ser?Glu?Glu?Glu?Lys?Lys?Glu?Glu?Met?Asp?Asn?Asn?Cys?Gln?Ser?Ile

580 585 590

ctc?gga?tac?gtt?gtg?cgc?tgg?gtt?gag?cac?ggt?gtt?ggt?tgc?tcc?aag 1824

Leu?Gly?Tyr?Val?Val?Arg?Trp?Val?Glu?His?Gly?Val?Gly?Cys?Ser?Lys

595 600 605

gtt?cca?gac?atc?cat?gac?atc?gac?ctc?atg?gaa?gac?cgc?gca?acg?ctg 1872

Val?Pro?Asp?Ile?His?Asp?Ile?Asp?Leu?Met?Glu?Asp?Arg?Ala?Thr?Leu

610 615 620

cgt?att?tcc?tcg?cag?atg?ctg?gcc?aac?tgg?atc?cgc?cat?gat?gtt?gtc 1920

Arg?Ile?Ser?Ser?Gln?Met?Leu?Ala?Asn?Trp?Ile?Arg?His?Asp?Val?Val

625 630 635 640

tcg?aag?gag?cag?gtc?ttg?gag?tca?ctg?gaa?cga?atg?gca?gtg?gtc?gtc 1968

Ser?Lys?Glu?Gln?Val?Leu?Glu?Ser?Leu?Glu?Arg?Met?Ala?Val?Val?Val

645 650 655

gac?aag?caa?aat?gcg?ggc?gac?gag?gcc?tac?cgc?gat?atg?gcg?ccg?aag 2016

Asp?Lys?Gln?Asn?Ala?Gly?Asp?Glu?Ala?Tyr?Arg?Asp?Met?Ala?Pro?Lys

660 665 670

tac?gac?gcc?tcc?ctc?gcc?ttc?cag?gcg?gct?aag?gac?ttg?att?ttc?gaa 2064

Tyr?Asp?Ala?Ser?Leu?Ala?Phe?Gln?Ala?Ala?Lys?Asp?Leu?Ile?Phe?Glu

675 680 685

ggc?acc?aag?tcc?cca?tcg?ggc?tac?acc?gag?ccc?atc?ttg?cac?gca?cgc 2112

Gly?Thr?Lys?Ser?Pro?Ser?Gly?Tyr?Thr?Glu?Pro?Ile?Leu?His?Ala?Arg

690 695 700

cgc?cgc?gag?ttc?aaa?gca?aaa?aac?taagcacgct?tttcgacgct?tac 2159

Arg?Arg?Glu?Phe?Lys?Ala?Lys?Asn

705 710

<210>596

<211>712

<212>PRT

＜213〉Corynebacterium glutamicum

<400>596

Met?Gln?Val?Ala?Lys?Val?Leu?Tyr?Asp?Phe?Val?Thr?Glu?Ala?Val?Leu

1 5 10 15

Pro?Arg?Val?Gly?Val?Asp?Ala?Glu?Lys?Phe?Trp?Ser?Gly?Phe?Ala?Ala

20 25 30

Ile?Ala?Arg?Asp?Leu?Thr?Pro?Arg?Asn?Arg?Glu?Leu?Leu?Ala?Arg?Arg

35 40 45

Asp?Glu?Leu?Gln?Met?Leu?Ile?Asp?Asp?Tyr?His?Arg?Asn?Asn?Ser?Gly

50 55 60

Thr?Ile?Asp?Gln?Glu?Ala?Tyr?Glu?Asp?Phe?Leu?Lys?Glu?Ile?Gly?Tyr

65 70 75 80

Leu?Val?Glu?Glu?Pro?Glu?Ala?Ala?Glu?Ile?Arg?Thr?Gln?Asn?Val?Asp

85 90 95

Thr?Glu?Ile?Ser?Ser?Thr?Ala?Gly?Pro?Gln?Leu?Val?Val?Pro?Ile?Leu

100 105 110

Asn?Ala?Arg?Phe?Ala?Leu?Asn?Ala?Ala?Asn?Ala?Arg?Trp?Gly?Ser?Leu

115 120 125

Tyr?Asp?Ala?Leu?Tyr?Gly?Thr?Asn?Ala?Ile?Pro?Glu?Thr?Asp?Gly?Ala

130 135 140

Glu?Lys?Gly?Lys?Glu?Tyr?Asn?Pro?Val?Arg?Gly?Gln?Lys?Val?Ile?Glu

145 150 155 160

Trp?Gly?Arg?Glu?Phe?Leu?Asp?Ser?Val?Val?Pro?Leu?Asp?Gly?Ala?Ser

165 170 175

His?Ala?Asp?Val?Glu?Lys?Tyr?Asn?Ile?Thr?Asp?Gly?Lys?Leu?Ala?Ala

180 185 190

His?Ile?Gly?Asp?Ser?Val?Tyr?Arg?Leu?Lys?Asn?Arg?Glu?Ser?Tyr?Arg

195 200 205

Gly?Phe?Thr?Gly?Asn?Phe?Leu?Asp?Pro?Glu?Ala?Ile?Leu?Leu?Glu?Thr

210 215 220

Asn?Gly?Leu?His?Ile?Glu?Leu?Gln?Ile?Asp?Pro?Val?His?Pro?Ile?Gly

225 230 235 240

Lys?Ala?Asp?Lys?Thr?Gly?Leu?Lys?Asp?Ile?Val?Leu?Glu?Ser?Ala?Ile

245 250 255

Thr?Thr?Ile?Met?Asp?Phe?Glu?Asp?Ser?Val?Ala?Ala?Val?Asp?Ala?Glu

260 265 270

Asp?Lys?Thr?Leu?Gly?Tyr?Ser?Asn?Trp?Phe?Gly?Leu?Asn?Thr?Gly?Glu

275 280 285

Leu?Lys?Glu?Glu?Met?Ser?Lys?Asn?Gly?Arg?Ile?Phe?Thr?Arg?Glu?Leu

290 295 300

Asn?Lys?Asp?Arg?Val?Tyr?Ile?Gly?Arg?Asn?Gly?Thr?Glu?Leu?Val?Leu

305 310 315 320

His?Gly?Arg?Ser?Leu?Leu?Phe?Val?Arg?Asn?Val?Gly?His?Leu?Met?Gln

325 330 335

Asn?Pro?Ser?Ile?Leu?Ile?Asp?Gly?Glu?Glu?Ile?Phe?Glu?Gly?Ile?Met

340 345 350

Asp?Ala?Val?Leu?Thr?Thr?Val?Cys?Ala?Ile?Pro?Gly?Ile?Ala?Pro?Gln

355 360 365

Asn?Lys?Met?Arg?Asn?Ser?Arg?Lys?Gly?Ser?Ile?Tyr?Ile?Val?Lys?Pro

370 375 380

Lys?Gln?His?Gly?Pro?Glu?Glu?Val?Ala?Phe?Thr?Asn?Glu?Leu?Phe?Gly

385 390 395 400

Arg?Val?Glu?Asp?Leu?Leu?Asp?Leu?Pro?Arg?His?Thr?Leu?Lys?Val?Gly

405 410 415

Val?Met?Asp?Glu?Glu?Arg?Arg?Thr?Ser?Val?Asn?Leu?Asp?Ala?Ser?Ile

420 425 430

Met?Glu?Val?Ala?Asp?Arg?Leu?Ala?Phe?Ile?Asn?Thr?Gly?Phe?Leu?Asp

435 440 445

Arg?Thr?Gly?Asp?Glu?Ile?His?Thr?Ser?Met?Glu?Ala?Gly?Ala?Met?Val

450 455 460

Arg?Lys?Ala?Asp?Met?Gln?Thr?Ala?Pro?Trp?Lys?Gln?Ala?Tyr?Glu?Asn

465 470 475 480

Ash?Asn?Val?Asp?Ala?Gly?Ile?Gln?Arg?Gly?Leu?Pro?Gly?Lys?Ala?Gln

485 490 495

Ile?Gly?Lys?Gly?Met?Trp?Ala?Met?Thr?Glu?Leu?Met?Ala?Glu?Met?Leu

500 505 510

Glu?Lys?Lys?Ile?Gly?Gln?Pro?Arg?Glu?Gly?Ala?Asn?Thr?Ala?Trp?Val

515 520 525

Pro?Ser?Pro?Thr?Gly?Ala?Thr?Leu?His?Ala?Thr?His?Tyr?His?Leu?Val

530 535 540

Asp?Val?Phe?Lys?Val?Gln?Asp?Glu?Leu?Arg?Ala?Ala?Gly?Arg?Arg?Asp

545 550 555 560

Ser?Leu?Arg?Asn?Ile?Leu?Thr?Ile?Ser?Thr?Ala?Pro?Asn?Thr?Asn?Trp

565 570 575

Ser?Glu?Glu?Glu?Lys?Lys?Glu?Glu?Met?Asp?Asn?Asn?Cys?Gln?Ser?Ile

580 585 590

Leu?Gly?Tyr?Val?Val?Arg?Trp?Val?Glu?His?Gly?Val?Gly?Cys?Ser?Lys

595 600 605

Val?Pro?Asp?Ile?His?Asp?Ile?Asp?Leu?Met?Glu?Asp?Arg?Ala?Thr?Leu

610 615 620

Arg?Ile?Ser?Ser?Gln?Met?Leu?Ala?Asn?Trp?Ile?Arg?His?Asp?Val?Val

625 630 635 640

Ser?Lys?Glu?Gln?Val?Leu?Glu?Ser?Leu?Glu?Arg?Met?Ala?Val?Val?Val

645 650 655

Asp?Lys?Gln?Asn?Ala?Gly?Asp?Glu?Ala?Tyr?Arg?Asp?Met?Ala?Pro?Lys

660 665 670

Tyr?Asp?Ala?Ser?Leu?Ala?Phe?Gln?Ala?Ala?Lys?Asp?Leu?Ile?Phe?Glu

675 680 685

Gly?Thr?Lys?Ser?Pro?Ser?Gly?Tyr?Thr?Glu?Pro?Ile?Leu?His?Ala?Arg

690 695 700

Arg?Arg?Glu?Phe?Lys?Ala?Lys?Asn

705 710

<210>597

<211>873

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(850)

<223>RXA01089

<400>597

aaaaattcgg?ttcacaaaag?gtttatcagt?ccagcttaaa?cccatcgcac?gggcgggaga 60

attagactca?aggcacatca?cattgaagga?gcttcttatc?ttg?tct?cga?ttt?gct 115

Leu?Ser?Arg?Phe?Ala

1 5

gcc?aac?ctg?tca?ttg?act?ttt?act?gag?cta?gat?ttc?ctg?gat?cgt?ttt 163

Ala?Asn?Leu?Ser?Leu?Thr?Phe?Thr?Glu?Leu?Asp?Phe?Leu?Asp?Arg?Phe

10 15 20

gat?gcc?gct?tcg?aag?cat?gct?ttc?agt?gcc?gtg?gag?ttt?cag?tac?cct 211

Asp?Ala?Ala?Ser?Lys?His?Ala?Phe?Ser?Ala?Val?Glu?Phe?Gln?Tyr?Pro

25 30 35

tac?gat?ttc?gat?gtt?caa?gag?att?aaa?cag?cgt?gct?gat?tcc?gca?ggt 259

Tyr?Asp?Phe?Asp?Val?Gln?Glu?Ile?Lys?Gln?Arg?Ala?Asp?Ser?Ala?Gly

40 45 50

ctg?ccc?att?gaa?ctg?ttc?aat?gcc?cca?cct?ggg?gat?act?ttt?ggt?ctt 307

Leu?Pro?Ile?Glu?Leu?Phe?Asn?Ala?Pro?Pro?Gly?Asp?Thr?Phe?Gly?Leu

55 60 65

gcg?gca?ctg?gct?tcc?cct?gaa?gac?ttt?caa?caa?tcc?atc?gag?cag?gcc 355

Ala?Ala?Leu?Ala?Ser?Pro?Glu?Asp?Phe?Gln?Gln?Ser?Ile?Glu?Gln?Ala

70 75 80 85

atc?acg?tac?gcc?aca?gtg?ttg?aag?cca?aag?aag?atg?cat?gtc?atg?gct 403

Ile?Thr?Tyr?Ala?Thr?Val?Leu?Lys?Pro?Lys?Lys?Met?His?Val?Met?Ala

90 95 100

ggc?atc?gcg?gac?gta?acc?tca?gaa?acc?acg?gcg?cgc?tat?gtg?gag?aat 451

Gly?Ile?Ala?Asp?Val?Thr?Ser?Glu?Thr?Thr?Ala?Arg?Tyr?Val?Glu?Asn

105 110 115

att?cgc?tgg?gct?gcg?cag?caa?cta?gac?aag?ctc?gac?gtt?gtc?gtt?gtt 499

Ile?Arg?Trp?Ala?Ala?Gln?Gln?Leu?Asp?Lys?Leu?Asp?Val?Val?Val?Val

120 125 130

att?gaa?cca?att?aat?cac?tat?tcg?gtt?ccc?ggt?tat?ttc?ctg?cac?act 547

Ile?Glu?Pro?Ile?Asn?His?Tyr?Ser?Val?Pro?Gly?Tyr?Phe?Leu?His?Thr

135 140 145

tta?gag?cag?gcg?tat?tgg?ctt?atc?gac?agc?att?gcc?cac?ccc?aat?gtg 595

Leu?Glu?Gln?Ala?Tyr?Trp?Leu?Ile?Asp?Ser?Ile?Ala?His?Pro?Asn?Val

150 155 160 165

aag?atc?tta?ttc?gat?act?ttc?cac?ctt?cag?cag?att?cat?ggc?aat?ctc 643

Lys?Ile?Leu?Phe?Asp?Thr?Phe?His?Leu?Gln?Gln?Ile?His?Gly?Asn?Leu

170 175 180

acc?cgc?cgc?ctg?cgc?gag?gtt?cat?ggc?gca?ggt?ctt?ttg?gga?cac?gtg 691

Thr?Arg?Arg?Leu?Arg?Glu?Val?His?Gly?Ala?Gly?Leu?Leu?Gly?His?Val

185 190 195

caa?gtg?gcc?tca?gtt?cct?gat?cga?cac?gaa?cct?ggc?act?ggc?gaa?gtc 739

Gln?Val?Ala?Ser?Val?Pro?Asp?Arg?His?Glu?Pro?Gly?Thr?Gly?Glu?Val

200 205 210

aat?gcg?gcg?tat?atc?ttc?caa?ctc?cta?agc?gaa?ctg?gga?tat?gac?ggt 787

Asn?Ala?Ala?Tyr?Ile?Phe?Gln?Leu?Leu?Ser?Glu?Leu?Gly?Tyr?Asp?Gly

215 220 225

gtc?atc?gct?ggc?gaa?tac?cac?cct?gct?ggt?gaa?act?aca?gcc?ggt?ttg 835

Val?Ile?Ala?Gly?Glu?Tyr?His?Pro?Ala?Gly?Glu?Thr?Thr?Ala?Gly?Leu

230 235 240 245

ggc?tgg?ttg?gag?ctc?tagatcgtaa?gtggtgtcgt?acc 873

Gly?Trp?Leu?Glu?Leu

250

<210>598

<211>250

<212>PRT

＜213〉Corynebacterium glutamicum

<400>598

Leu?Ser?Arg?Phe?Ala?Ala?Asn?Leu?Ser?Leu?Thr?Phe?Thr?Glu?Leu?Asp

1 5 10 15

Phe?Leu?Asp?Arg?Phe?Asp?Ala?Ala?Ser?Lys?His?Ala?Phe?Ser?Ala?Val

20 25 30

Glu?Phe?Gln?Tyr?Pro?Tyr?Asp?Phe?Asp?Val?Gln?Glu?Ile?Lys?Gln?Arg

35 40 45

Ala?Asp?Ser?Ala?Gly?Leu?Pro?Ile?Glu?Leu?Phe?Asn?Ala?Pro?Pro?Gly

50 55 60

Asp?Thr?Phe?Gly?Leu?Ala?Ala?Leu?Ala?Ser?Pro?Glu?Asp?Phe?Gln?Gln

65 70 75 80

Ser?Ile?Glu?Gln?Ala?Ile?Thr?Tyr?Ala?Thr?Val?Leu?Lys?Pro?Lys?Lys

85 90 95

Met?His?Val?Met?Ala?Gly?Ile?Ala?Asp?Val?Thr?Ser?Glu?Thr?Thr?Ala

100 105 110

Arg?Tyr?Val?Glu?Asn?Ile?Arg?Trp?Ala?Ala?Gln?Gln?Leu?Asp?Lys?Leu

115 120 125

Asp?Val?Val?Val?Val?Ile?Glu?Pro?Ile?Asn?His?Tyr?Ser?Val?Pro?Gly

130 135 140

Tyr?Phe?Leu?His?Thr?Leu?Glu?Gln?Ala?Tyr?Trp?Leu?Ile?Asp?Ser?Ile

145 150 155 160

Ala?His?Pro?Asn?Val?Lys?Ile?Leu?Phe?Asp?Thr?Phe?His?Leu?Gln?G1n

165 170 175

Ile?His?Gly?Asn?Leu?Thr?Arg?Arg?Leu?Arg?Glu?Val?His?Gly?Ala?Gly

180 185 190

Leu?Leu?Gly?His?Val?Gln?Val?Ala?Ser?Val?Pro?Asp?Arg?His?Glu?Pro

195 200 205

Gly?Thr?Gly?Glu?Val?Asn?Ala?Ala?Tyr?Ile?Phe?Gln?Leu?Leu?Ser?Glu

210 215 220

Leu?Gly?Tyr?Asp?Gly?Val?Ile?Ala?Gly?Glu?Tyr?His?Pro?Ala?Gly?Glu

225 230 235 240

Thr?Thr?Ala?Gly?Leu?Gly?Trp?Leu?Glu?Leu

245 250

<210>599

<211>897

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(874)

<223>RXA01886

<400>599

gcgaagctgc?acgcaccgca?ctactcatcg?cactcggcgc?catccgaagc?gtagaaaccg 60

gcgcaaccat?caaccttgct?gaaagcatcg?aggtttaacc?atg?act?ttt?aaa?ctc 115

Met?Thr?Phe?Lys?Leu

1 5

gca?gca?tgc?gca?gag?atg?atc?tac?cag?gac?ctg?cct?ttc?gag?gag?agg 163

Ala?Ala?Cys?Ala?Glu?Met?Ile?Tyr?Gln?Asp?Leu?Pro?Phe?Glu?Glu?Arg

10 15 20

gtc?aag?acg?atc?tct?gat?cag?gga?ttc?ctc?gtg?gaa?att?tgg?gac?tgg 211

Val?Lys?Thr?Ile?Ser?Asp?Gln?Gly?Phe?Leu?Val?Glu?Ile?Trp?Asp?Trp

25 30 35

tcc?aca?aaa?gac?atc?gat?gcg?ctc?gtg?gca?aca?ggc?gcg?gaa?ttt?tcc 259

Ser?Thr?Lys?Asp?Ile?Asp?Ala?Leu?Val?Ala?Thr?Gly?Ala?Glu?Phe?Ser

40 45 50

tcc?atg?acg?ggc?tac?ctg?cgc?ggg?gat?ctg?att?act?gaa?cag?ggc?cgc 307

Ser?Met?Thr?Gly?Tyr?Leu?Arg?Gly?Asp?Leu?Ile?Thr?Glu?Gln?Gly?Arg

55 60 65

gcg?gag?ctc?ttg?gca?acc?gct?tcg?gag?tcc?ttg?gcg?gtg?gcg?gaa?aag 355

Ala?Glu?Leu?Leu?Ala?Thr?Ala?Ser?Glu?Ser?Leu?Ala?Val?Ala?Glu?Lys

70 75 80 85

ctc?aac?tgc?ccc?cgg?ctg?aat?ctg?cat?gga?act?ggc?ctt?gga?ccg?cag 403

Leu?Asn?Cys?Pro?Arg?Leu?Asn?Leu?His?Gly?Thr?Gly?Leu?Gly?Pro?Gln

90 95 100

gga?cta?cct?gtt?act?ccc?att?gaa?gtg?gtt?acc?cca?gaa?atg?tgg?ctc 451

Gly?Leu?Pro?Val?Thr?Pro?Ile?Glu?Val?Val?Thr?Pro?Glu?Met?Trp?Leu

105 110 115

tac?gct?gct?gaa?acg?ctc?cgc?cag?atc?gct?gag?ctg?ggg?gag?cgc?gca 499

Tyr?Ala?Ala?Glu?Thr?Leu?Arg?Gln?Ile?Ala?Glu?Leu?Gly?Glu?Arg?Ala

120 125 130

ggc?aag?gtt?ttc?gtg?ctg?gaa?aac?ctc?aac?ctc?gca?gtc?gat?cac?ccc 547

Gly?Lys?Val?Phe?Val?Leu?Glu?Asn?Leu?Asn?Leu?Ala?Val?Asp?His?Pro

135 140 145

ggc?act?cct?ttt?gcc?aag?gcc?act?gac?act?ttg?gcg?ctg?gtc?aag?gct 595

Gly?Thr?Pro?Phe?Ala?Lys?Ala?Thr?Asp?Thr?Leu?Ala?Leu?Val?Lys?Ala

150 155 160 165

gtc?aat?cac?ccg?aat?ctg?cgc?ctc?aac?ctg?gat?ttg?tac?cac?gcc?cag 643

Val?Asn?His?Pro?Asn?Leu?Arg?Leu?Asn?Leu?Asp?Leu?Tyr?His?Ala?Gln

170 175 180

att?ggc?gaa?gga?aac?ctc?att?gag?ctg?ctc?cgt?gag?gcg?cag?cca?ttc 691

Ile?Gly?Glu?Gly?Asn?Leu?Ile?Glu?Leu?Leu?Arg?Glu?Ala?Gln?Pro?Phe

185 190 195

atc?ggc?gaa?atc?cag?gtt?gcc?gat?gtc?ccc?ggc?cgc?atg?gaa?ccc?ggc 739

Ile?Gly?Glu?Ile?Gln?Val?Ala?Asp?Val?Pro?Gly?Arg?Met?Glu?Pro?Gly

200 205 210

acc?ggc?gag?atc?aac?tac?cag?ggc?gtc?gcg?aaa?gct?ctc?gcc?gcg?atg 787

Thr?Gly?Glu?Ile?Asn?Tyr?Gln?Gly?Val?Ala?Lys?Ala?Leu?Ala?Ala?Met

215 220 225

ggc?tac?gac?ggc?gtc?atc?ggc?atg?gag?gcg?tgg?gca?tcg?ggc?gac?tcc 835

Gly?Tyr?Asp?Gly?Val?Ile?Gly?Met?Glu?Ala?Trp?Ala?Ser?Gly?Asp?Ser

230 235 240 245

agc?gac?gcg?ctg?cag?gcg?ttg?aag?tca?gcg?ttc?acg?gtc?taaattgctt 884

Ser?Asp?Ala?Leu?Gln?Ala?Leu?Lys?Ser?Ala?Phe?Thr?Val

250 255

atcgacgcac?ccc 897

<210>600

<211>258

<212>PRT

＜213〉Corynebacterium glutamicum

<400>600

Met?Thr?Phe?Lys?Leu?Ala?Ala?Cys?Ala?Glu?Met?Ile?Tyr?Gln?Asp?Leu

1 5 10 15

Pro?Phe?Glu?Glu?Arg?Val?Lys?Thr?Ile?Ser?Asp?Gln?Gly?Phe?Leu?Val

20 25 30

Glu?Ile?Trp?Asp?Trp?Ser?Thr?Lys?Asp?Ile?Asp?Ala?Leu?Val?Ala?Thr

35 40 45

Gly?Ala?Glu?Phe?Ser?Ser?Met?Thr?Gly?Tyr?Leu?Arg?Gly?Asp?Leu?Ile

50 55 60

Thr?Glu?Gln?Gly?Arg?Ala?Glu?Leu?Leu?Ala?Thr?Ala?Ser?Glu?Ser?Leu

65 70 75 80

Ala?Val?Ala?Glu?Lys?Leu?Asn?Cys?Pro?Arg?Leu?Asn?Leu?His?Gly?Thr

85 90 95

Gly?Leu?Gly?Pro?Gln?Gly?Leu?Pro?Val?Thr?Pro?Ile?Glu?Val?Val?Thr

100 105 110

Pro?Glu?Met?Trp?Leu?Tyr?Ala?Ala?Glu?Thr?Leu?Arg?Gln?Ile?Ala?Glu

115 120 125

Leu?Gly?Glu?Arg?Ala?Gly?Lys?Val?Phe?Val?Leu?Glu?Asn?Leu?Asn?Leu

130 135 140

Ala?Val?Asp?His?Pro?Gly?Thr?Pro?Phe?Ala?Lys?Ala?Thr?Asp?Thr?Leu

145 150 155 160

Ala?Leu?Val?Lys?Ala?Val?Asn?His?Pro?Asn?Leu?Arg?Leu?Asn?Leu?Asp

165 170 175

Leu?Tyr?His?Ala?Gln?Ile?Gly?Glu?Gly?Asn?Leu?Ile?Glu?Leu?Leu?Arg

180 185 190

Glu?Ala?Gln?Pro?Phe?Ile?Gly?Glu?Ile?Gln?Val?Ala?Asp?Val?Pro?Gly

195 200 205

Arg?Met?Glu?Pro?Gly?Thr?Gly?Glu?Ile?Asn?Tyr?Gln?Gly?Val?Ala?Lys

210 215 220

Ala?Leu?Ala?Ala?Met?Gly?Tyr?Asp?Gly?Val?Ile?Gly?Met?Glu?Ala?Trp

225 230 235 240

Ala?Ser?Gly?Asp?Ser?Ser?Asp?Ala?Leu?Gln?Ala?Leu?Lys?Ser?Ala?Phe

245 250 255

Thr?Val

<210>601

<211>1575

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(41)..(1552)

<223>RXN03117

<400>601

tgtgcaacat?tagttcgtta?agaagagtca?cattccagcc?atg?att?acc?cac?gaa 55

Met?Ile?Thr?His?Glu

1 5

gtg?cgc?acc?cac?cgt?tct?gcg?gaa?gag?ttc?ccg?tac?aag?aag?cac?ctg 103

Val?Arg?Thr?His?Arg?Ser?Ala?Glu?Glu?Phe?Pro?Tyr?Lys?Lys?His?Leu

10 15 20

gct?cac?aag?atg?gct?cgc?gtt?gca?gcc?gac?cca?gtt?gag?gtt?gct?gcg 151

Ala?His?Lys?Met?Ala?Arg?Val?Ala?Ala?Asp?Pro?Val?Glu?Val?Ala?Ala

25 30 35

gac?act?cag?gaa?atg?atc?atc?acc?cgc?atc?atc?gac?aat?gca?tcg?gtg 199

Asp?Thr?Gln?Glu?Met?Ile?Ile?Thr?Arg?Ile?Ile?Asp?Asn?Ala?Ser?Val

40 45 50

cag?gca?gct?tcc?gtg?ttg?cgt?cga?cca?gtt?agc?tct?gcc?cgt?gcg?atg 247

Gln?Ala?Ala?Ser?Val?Leu?Arg?Arg?Pro?Val?Ser?Ser?Ala?Arg?Ala?Met

55 60 65

gca?cag?gtc?agg?cca?gtt?acc?gat?ggt?cgg?ggt?gca?tct?gtt?ttc?ggt 295

Ala?Gln?Val?Arg?Pro?Val?Thr?Asp?Gly?Arg?Gly?Ala?Ser?Val?Phe?Gly

70 75 80 85

ctg?cca?gga?cgt?tat?gcc?gcg?gaa?tgg?gct?gcg?ctt?gct?aac?ggc?act 343

Leu?Pro?Gly?Arg?Tyr?Ala?Ala?Glu?Trp?Ala?Ala?Leu?Ala?Asn?Gly?Thr

90 95 100

gcg?gtg?cgt?gag?ctt?gat?ttc?cat?gac?acg?ttc?ctc?gct?gcg?gaa?tac 391

Ala?Val?Arg?Glu?Leu?Asp?Phe?His?Asp?Thr?Phe?Leu?Ala?Ala?Glu?Tyr

105 110 115

tcc?cac?cca?gga?gat?aac?att?cct?ccg?att?ttg?gct?gca?gca?cag?cag 439

Ser?His?Pro?Gly?Asp?Asn?Ile?Pro?Pro?Ile?Leu?Ala?Ala?Ala?Gln?Gln

120 125 130

gct?gga?aaa?ggt?ggc?aag?gat?ctg?atc?cgt?ggc?atc?gct?act?ggg?tat 487

Ala?Gly?Lys?Gly?Gly?Lys?Asp?Leu?Ile?Arg?Gly?Ile?Ala?Thr?Gly?Tyr

135 140 145

gag?att?cag?gtt?aac?ttg?gtg?cgt?gga?atg?tgc?ctg?cat?gag?cac?aag 535

Glu?Ile?Gln?Val?Asn?Leu?Val?Arg?Gly?Met?Cys?Leu?His?Glu?His?Lys

150 155 160 165

att?gat?cac?gtt?gct?cat?ctt?gga?cca?tca?gcg?gct?gct?ggt?atc?gga 583

Ile?Asp?His?Val?Ala?His?Leu?Gly?Pro?Ser?Ala?Ala?Ala?Gly?Ile?Gly

170 175 180

acc?ttg?cta?gac?cta?gat?gtg?gac?acc?atc?tac?cag?gca?att?ggt?cag 631

Thr?Leu?Leu?Asp?Leu?Asp?Val?Asp?Thr?Ile?Tyr?Gln?Ala?Ile?Gly?Gln

185 190 195

gca?ttg?cac?acc?acc?acg?gcg?acg?agg?cag?tcc?cgt?aaa?ggt?gcg?att 679

Ala?Leu?His?Thr?Thr?Thr?Ala?Thr?Arg?Gln?Ser?Arg?Lys?Gly?Ala?Ile

200 205 210

tct?tca?tgg?aag?gca?ttt?gct?cct?gcg?ttt?gcg?ggc?aag?atg?tcc?atc 727

Ser?Ser?Trp?Lys?Ala?Phe?Ala?Pro?Ala?Phe?Ala?Gly?Lys?Met?Ser?Ile

215 220 225

gag?gca?gta?gat?cgc?gca?atg?cgt?ggc?gag?ggc?gca?ccg?tca?cca?atc 775

Glu?Ala?Val?Asp?Arg?Ala?Met?Arg?Gly?Glu?Gly?Ala?Pro?Ser?Pro?Ile

230 235 240 245

tgg?gaa?ggc?gaa?gac?ggc?gta?atc?gcg?tgg?ctg?ctg?tcc?ggt?ctt?gat 823

Trp?Glu?Gly?Glu?Asp?Gly?Val?Ile?Ala?Trp?Leu?Leu?Ser?Gly?Leu?Asp

250 255 260

cac?atc?tac?acc?att?cct?ttg?cct?gca?gaa?ggt?gaa?gcc?aaa?cga?gca 871

His?Ile?Tyr?Thr?Ile?Pro?Leu?Pro?Ala?Glu?Gly?Glu?Ala?Lys?Arg?Ala

265 270 275

atc?ttg?gat?acc?tac?acc?aag?gaa?cac?tcg?gcg?gaa?tac?cag?tca?cag 919

Ile?Leu?Asp?Thr?Tyr?Thr?Lys?Glu?His?Ser?Ala?Glu?Tyr?Gln?Ser?Gln

280 285 290

gca?ccg?atc?gac?ttg?gcg?cgc?agc?atg?ggg?gag?aag?ctg?gca?gca?cag 967

Ala?Pro?Ile?Asp?Leu?Ala?Arg?Ser?Met?Gly?Glu?Lys?Leu?Ala?Ala?Gln

295 300 305

ggc?ttg?gac?ctg?cgt?gat?gtg?gac?tcc?atc?gtt?ttg?cac?acc?tcc?cac 1015

Gly?Leu?Asp?Leu?Arg?Asp?Val?Asp?Ser?Ile?Val?Leu?His?Thr?Ser?His

310 315 320 325

cac?act?cac?tac?gtg?atc?ggc?acc?gga?tct?aat?gat?cca?cag?aag?ttc 1063

His?Thr?His?Tyr?Val?Ile?Gly?Thr?Gly?Ser?Asn?Asp?Pro?Gln?Lys?Phe

330 335 340

gat?cca?gat?gca?tcg?cga?gaa?acc?ctt?gat?cac?tcc?atc?atg?tac?att 1111

Asp?Pro?Asp?Ala?Ser?Arg?Glu?Thr?Leu?Asp?His?Ser?Ile?Met?Tyr?Ile

345 350 355

ttc?gct?gtc?gcg?ctg?aag?gat?cgc?gcg?tgg?cac?cac?gag?cgt?tcc?tat 1159

Phe?Ala?Val?Ala?Leu?Lys?Asp?Arg?Ala?Trp?His?His?Glu?Arg?Ser?Tyr

360 365 370

gct?cct?gag?cga?gcc?cac?cgc?cga?gag?acc?atc?gag?ctg?tgg?aac?aag 1207

Ala?Pro?Glu?Arg?Ala?His?Arg?Arg?Glu?Thr?Ile?Glu?Leu?Trp?Asn?Lys

375 380 385

att?tcc?acg?gtg?gag?gat?cct?gaa?tgg?acc?agg?cgt?tac?cac?tcc?gtt 1255

Ile?Ser?Thr?Val?Glu?Asp?Pro?Glu?Trp?Thr?Arg?Arg?Tyr?His?Ser?Val

390 395 400 405

gat?cct?gca?gaa?aag?gcc?ttc?ggc?gca?cgc?gca?gtg?atc?acc?ttc?aag 1303

Asp?Pro?Ala?Glu?Lys?Ala?Phe?Gly?Ala?Arg?Ala?Val?Ile?Thr?Phe?Lys

410 415 420

gat?gga?acc?gtc?gtg?gaa?gat?gaa?ctg?gct?gtg?gcg?aat?gcg?cat?cct 1351

Asp?Gly?Thr?Val?Val?Glu?Asp?Glu?Leu?Ala?Val?Ala?Asn?Ala?His?Pro

425 430 435

ctg?gga?gca?cgg?cct?ttc?gct?agg?gag?cag?tac?att?cag?aaa?ttc?cgc 1399

Leu?Gly?Ala?Arg?Pro?Phe?Ala?Arg?Glu?Gln?Tyr?Ile?Gln?Lys?Phe?Arg

440 445 450

acc?ttg?gct?gaa?ggt?gtt?gtg?tcc?gaa?aag?gaa?cag?gat?cgc?ttc?ttg 1447

Thr?Leu?Ala?Glu?Gly?Val?Val?Ser?Glu?Lys?Glu?Gln?Asp?Arg?Phe?Leu

455 460 465

gat?gcg?gca?cag?cgt?acg?cac?gag?ctt?gag?gat?ctt?tca?gaa?ctc?aac 1495

Asp?Ala?Ala?Gln?Arg?Thr?His?Glu?Leu?Glu?Asp?Leu?Ser?Glu?Leu?Asn

470 475 480 485

att?gaa?ttg?gat?gcc?gat?att?ttg?gcc?aag?gct?cct?gtg?att?ccg?gaa 1543

Ile?Glu?Leu?Asp?Ala?Asp?Ile?Leu?Ala?Lys?Ala?Pro?Val?Ile?Pro?Glu

490 495 500

gga?ctg?ttc?tgatggcggg?tttgttttcc?tct 1575

Gly?Leu?Phe

<210>602

<211>504

<212>PRT

＜213〉Corynebacterium glutamicum

<400>602

Met?Ile?Thr?His?Glu?Val?Arg?Thr?His?Arg?Ser?Ala?Glu?Glu?Phe?Pro

1 5 10 15

Tyr?Lys?Lys?His?Leu?Ala?His?Lys?Met?Ala?Arg?Val?Ala?Ala?Asp?Pro

20 25 30

Val?Glu?Val?Ala?Ala?Asp?Thr?Gln?Glu?Met?Ile?Ile?Thr?Arg?Ile?Ile

35 40 45

Asp?Asn?Ala?Ser?Val?Gln?Ala?Ala?Ser?Val?Leu?Arg?Arg?Pro?Val?Ser

50 55 60

Ser?Ala?Arg?Ala?Met?Ala?Gln?Val?Arg?Pro?Val?Thr?Asp?Gly?Arg?Gly

65 70 75 80

Ala?Ser?Val?Phe?Gly?Leu?Pro?Gly?Arg?Tyr?Ala?Ala?Glu?Trp?Ala?Ala

85 90 95

Leu?Ala?Asn?Gly?Thr?Ala?Val?Arg?Glu?Leu?Asp?Phe?His?Asp?Thr?Phe

100 105 110

Leu?Ala?Ala?Glu?Tyr?Ser?His?Pro?Gly?Asp?Asn?Ile?Pro?Pro?Ile?Leu

115 120 125

Ala?Ala?Ala?Gln?Gln?Ala?Gly?Lys?Gly?Gly?Lys?Asp?Leu?Ile?Arg?Gly

130 135 140

Ile?Ala?Thr?Gly?Tyr?Glu?Ile?Gln?Val?Asn?Leu?Val?Arg?Gly?Met?Cys

145 150 155 160

Leu?His?Glu?His?Lys?Ile?Asp?His?Val?Ala?His?Leu?Gly?Pro?Ser?Ala

165 170 175

Ala?Ala?Gly?Ile?Gly?Thr?Leu?Leu?Asp?Leu?Asp?Val?Asp?Thr?Ile?Tyr

180 185 190

Gln?Ala?Ile?Gly?Gln?Ala?Leu?His?Thr?Thr?Thr?Ala?Thr?Arg?Gln?Ser

195 200 205

Arg?Lys?Gly?Ala?Ile?Ser?Ser?Trp?Lys?Ala?Phe?Ala?Pro?Ala?Phe?Ala

210 215 220

Gly?Lys?Met?Ser?Ile?Glu?Ala?Val?Asp?Arg?Ala?Met?Arg?Gly?Glu?Gly

225 230 235 240

Ala?Pro?Ser?Pro?Ile?Trp?Glu?Gly?Glu?Asp?Gly?Val?Ile?Ala?Trp?Leu

245 250 255

Leu?Ser?Gly?Leu?Asp?His?Ile?Tyr?Thr?Ile?Pro?Leu?Pro?Ala?Glu?Gly

260 265 270

Glu?Ala?Lys?Arg?Ala?Ile?Leu?Asp?Thr?Tyr?Thr?Lys?Glu?His?Ser?Ala

275 280 285

Glu?Tyr?Gln?Ser?Gln?Ala?Pro?Ile?Asp?Leu?Ala?Arg?Ser?Met?Gly?Glu

290 295 300

Lys?Leu?Ala?Ala?Gln?Gly?Leu?Asp?Leu?Arg?Asp?Val?Asp?Ser?Ile?Val

305 310 315 320

Leu?His?Thr?Ser?His?His?Thr?His?Tyr?Val?Ile?Gly?Thr?Gly?Ser?Asn

325 330 335

Asp?Pro?Gln?Lys?Phe?Asp?Pro?Asp?Ala?Ser?Arg?Glu?Thr?Leu?Asp?His

340 345 350

Ser?Ile?Met?Tyr?Ile?Phe?Ala?Val?Ala?Leu?Lys?Asp?Arg?Ala?Trp?His

355 360 365

His?Glu?Arg?Ser?Tyr?Ala?Pro?Glu?Arg?Ala?His?Arg?Arg?Glu?Thr?Ile

370 375 380

Glu?Leu?Trp?Asn?Lys?Ile?Ser?Thr?Val?Glu?Asp?Pro?Glu?Trp?Thr?Arg

385 390 395 400

Arg?Tyr?His?Ser?Val?Asp?Pro?Ala?Glu?Lys?Ala?Phe?Gly?Ala?Arg?Ala

405 410 415

Val?Ile?Thr?Phe?Lys?Asp?Gly?Thr?Val?Val?Glu?Asp?Glu?Leu?Ala?Val

420 425 430

Ala?Asn?Ala?His?Pro?Leu?Gly?Ala?Arg?Pro?Phe?Ala?Arg?Glu?Gln?Tyr

435 440 445

Ile?Gln?Lys?Phe?Arg?Thr?Leu?Ala?Glu?Gly?Val?Val?Ser?Glu?Lys?Glu

450 455 460

Gln?Asp?Arg?Phe?Leu?Asp?Ala?Ala?Gln?Arg?Thr?His?Glu?Leu?Glu?Asp

465 470 475 480

Leu?Ser?Glu?Leu?Asn?Ile?Glu?Leu?Asp?Ala?Asp?Ile?Leu?Ala?Lys?Ala

485 490 495

Pro?Val?Ile?Pro?Glu?Gly?Leu?Phe

500

<210>603

<211>975

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(975)

<223>FRXA00406

<400>603

gac?cca?gtt?gag?gtt?gct?gcg?gac?act?cag?gaa?atg?atc?atc?acc?cgc 48

Asp?Pro?Val?Glu?Val?Ala?Ala?Asp?Thr?Gln?Glu?Met?Ile?Ile?Thr?Arg

1 5 10 15

atc?atc?gac?aat?gca?tcg?gtg?cag?gca?gct?tcc?gtg?ttg?cgt?cga?cca 96

Ile?Ile?Asp?Asn?Ala?Ser?Val?Gln?Ala?Ala?Ser?Val?Leu?Arg?Arg?Pro

20 25 30

gtt?agc?tct?gcc?cgt?gcg?atg?gca?cag?gtc?agg?cca?gtt?acc?gat?ggt 144

Val?Ser?Ser?Ala?Arg?Ala?Met?Ala?Gln?Val?Arg?Pro?Val?Thr?Asp?Gly

35 40 45

cgg?ggt?gca?tct?gtt?ttc?ggt?ctg?cca?gga?cgt?tat?gcc?gcg?gaa?tgg 192

Arg?Gly?Ala?Ser?Val?Phe?Gly?Leu?Pro?Gly?Arg?Tyr?Ala?Ala?Glu?Trp

50 55 60

gct?gcg?ctt?gct?aac?ggc?act?gcg?gtg?cgt?gag?ctt?gat?ttc?cat?gac 240

Ala?Ala?Leu?Ala?Asn?Gly?Thr?Ala?Val?Arg?Glu?Leu?Asp?Phe?His?Asp

65 70 75 80

acg?ttc?ctc?gct?gcg?gaa?tac?tcc?cac?cca?gga?gat?aac?att?cct?ccg 288

Thr?Phe?Leu?Ala?Ala?Glu?Tyr?Ser?His?Pro?Gly?Asp?Asn?Ile?Pro?Pro

85 90 95

att?ttg?gct?gca?gca?cag?cag?gct?gga?aaa?ggt?ggc?aag?gat?ctg?atc 336

Ile?Leu?Ala?Ala?Ala?Gln?Gln?Ala?Gly?Lys?Gly?Gly?Lys?Asp?Leu?Ile

100 105 110

cgt?ggc?atc?gct?act?ggg?tat?gag?att?cag?gtt?aac?ttg?gtg?cgt?gga 384

Arg?Gly?Ile?Ala?Thr?Gly?Tyr?Glu?Ile?Gln?Val?Asn?Leu?Val?Arg?Gly

115 120 125

atg?tgc?ctg?cat?gag?cac?aag?att?gat?cac?gtt?gct?cat?ctt?gga?cca 432

Met?Cys?Leu?His?Glu?His?Lys?Ile?Asp?His?Val?Ala?His?Leu?Gly?Pro

130 135 140

tca?gcg?gct?gct?ggt?atc?gga?acc?ttg?cta?gac?cta?gat?gtg?gac?acc 480

Ser?Ala?Ala?Ala?Gly?Ile?Gly?Thr?Leu?Leu?Asp?Leu?Asp?Val?Asp?Thr

145 150 155 160

atc?tac?cag?gca?att?ggt?cag?gca?ttg?cac?acc?acc?acg?gcg?acg?agg 528

Ile?Tyr?Gln?Ala?Ile?Gly?Gln?Ala?Leu?His?Thr?Thr?Thr?Ala?Thr?Arg

165 170 175

cag?tcc?cgt?aaa?ggt?gcg?att?tct?tca?tgg?aag?gca?ttt?gct?cct?gcg 576

Gln?Ser?Arg?Lys?Gly?Ala?Ile?Ser?Ser?Trp?Lys?Ala?Phe?Ala?Pro?Ala

180 185 190

ttt?gcg?ggc?aag?atg?tcc?atc?gag?gca?gta?gat?cgc?gca?atg?cgt?ggc 624

Phe?Ala?Gly?Lys?Met?Ser?Ile?Glu?Ala?Val?Asp?Arg?Ala?Met?Arg?Gly

195 200 205

gag?ggc?gca?ccg?tca?cca?atc?tgg?gaa?ggc?gaa?gac?ggc?gta?atc?gcg 672

Glu?Gly?Ala?Pro?Ser?Pro?Ile?Trp?Glu?Gly?Glu?Asp?Gly?Val?Ile?Ala

210 215 220

tgg?ctg?ctg?tcc?ggt?ctt?gat?cac?atc?tac?acc?att?cct?ttg?cct?gca 720

Trp?Leu?Leu?Ser?Gly?Leu?Asp?His?Ile?Tyr?Thr?Ile?Pro?Leu?Pro?Ala

225 230 235 240

gaa?ggt?gaa?gcc?aaa?cga?gca?atc?ttg?gat?acc?tac?acc?aag?gaa?cac 768

Glu?Gly?Glu?Ala?Lys?Arg?Ala?Ile?Leu?Asp?Thr?Tyr?Thr?Lys?Glu?His

245 250 255

tcg?gcg?gaa?tac?cag?tca?cag?gca?ccg?atc?gac?ttg?gcg?cgc?agc?atg 816

Ser?Ala?Glu?Tyr?Gln?Ser?Gln?Ala?Pro?Ile?Asp?Leu?Ala?Arg?Ser?Met

260 265 270

ggg?gag?aag?ctg?gca?gca?cag?ggc?ttg?gac?ctg?cgt?gat?gtg?gac?tcc 864

Gly?Glu?Lys?Leu?Ala?Ala?Gln?Gly?Leu?Asp?Leu?Arg?Asp?Val?Asp?Ser

275 280 285

atc?gtt?ttg?cac?acc?tcc?cac?cac?act?cac?tac?gtg?atc?ggc?acc?gga 912

Ile?Val?Leu?His?Thr?Ser?His?His?Thr?His?Tyr?Val?Ile?Gly?Thr?Gly

290 295 300

tct?aat?gat?cca?cag?aag?ttc?gat?cca?gat?gca?tcg?cga?gaa?acc?ctt 960

Ser?Asn?Asp?Pro?Gln?Lys?Phe?Asp?Pro?Asp?Ala?Ser?Arg?Glu?Thr?Leu

305 310 315 320

gat?cac?tcc?atc?atg 975

Asp?His?Ser?Ile?Met

325

<210>604

<211>325

<212>PRT

＜213〉Corynebacterium glutamicum

<400>604

Asp?Pro?Val?Glu?Val?Ala?Ala?Asp?Thr?Gln?Glu?Met?Ile?Ile?Thr?Arg

1 5 l0 15

Ile?Ile?Asp?Asn?Ala?Ser?Val?Gln?Ala?Ala?Ser?Val?Leu?Arg?Arg?Pro

20 25 30

Val?Ser?Ser?Ala?Arg?Ala?Met?Ala?Gln?Val?Arg?Pro?Val?Thr?Asp?Gly

35 40 45

Arg?Gly?Ala?Ser?Val?Phe?Gly?Leu?Pro?Gly?Arg?Tyr?Ala?Ala?Glu?Trp

50 55 60

Ala?Ala?Leu?Ala?Asn?Gly?Thr?Ala?Val?Arg?Glu?Leu?Asp?Phe?His?Asp

65 70 75 80

Thr?Phe?Leu?Ala?Ala?Glu?Tyr?Ser?His?Pro?Gly?Asp?Asn?Ile?Pro?Pro

85 90 95

Ile?Leu?Ala?Ala?Ala?Gln?Gln?Ala?Gly?Lys?Gly?Gly?Lys?Asp?Leu?Ile

100 105 110

Arg?Gly?Ile?Ala?Thr?Gly?Tyr?Glu?Ile?Gln?Val?Asn?Leu?Val?Arg?Gly

115 120 125

Met?Cys?Leu?His?Glu?His?Lys?Ile?Asp?His?Val?Ala?His?Leu?Gly?Pro

130 135 140

Ser?Ala?Ala?Ala?Gly?Ile?Gly?Thr?Leu?Leu?Asp?Leu?Asp?Val?Asp?Thr

145 150 155 160

Ile?Tyr?Gln?Ala?Ile?Gly?Gln?Ala?Leu?His?Thr?Thr?Thr?Ala?Thr?Arg

165 170 175

Gln?Ser?Arg?Lys?Gly?Ala?Ile?Ser?Ser?Trp?Lys?Ala?Phe?Ala?Pro?Ala

180 185 190

Phe?Ala?Gly?Lys?Met?Ser?Ile?Glu?Ala?Val?Asp?Arg?Ala?Met?Arg?Gly

195 200 205

Glu?Gly?Ala?Pro?Ser?Pro?Ile?Trp?Glu?Gly?Glu?Asp?Gly?Val?Ile?Ala

210 215 220

Trp?Leu?Leu?Ser?Gly?Leu?Asp?His?Ile?Tyr?Thr?Ile?Pro?Leu?Pro?Ala

225 230 235 240

Glu?Gly?Glu?Ala?Lys?Arg?Ala?Ile?Leu?Asp?Thr?Tyr?Thr?Lys?Glu?His

245 250 255

Ser?Ala?Glu?Tyr?Gln?Ser?Gln?Ala?Pro?Ile?Asp?Leu?Ala?Arg?Ser?Met

260 265 270

Gly?Glu?Lys?Leu?Ala?Ala?Gln?Gly?Leu?Asp?Leu?Arg?Asp?Val?Asp?Ser

275 280 285

Ile?Val?Leu?His?Thr?Ser?His?His?Thr?His?Tyr?Val?Ile?Gly?Thr?Gly

290 295 300

Ser?Asn?Asp?Pro?Gln?Lys?Phe?Asp?Pro?Asp?Ala?Ser?Arg?Glu?Thr?Leu

305 310 315 320

Asp?His?Ser?Ile?Met

325

<210>605

<211>431

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(408)

<223>FRXA00514

<400>605

cac?gag?cgt?tcc?tat?gct?cct?gag?cga?gcc?ctc?cgc?cga?gag?acc?atc 48

His?Glu?Arg?Ser?Tyr?Ala?Pro?Glu?Arg?Ala?Leu?Arg?Arg?Glu?Thr?Ile

1 5 10 15

gag?ctg?tgg?aac?aag?att?tcc?acg?gtg?gag?gat?cct?gaa?tgg?acc?agg 96

Glu?Leu?Trp?Asn?Lys?Ile?Ser?Thr?Val?Glu?Asp?Pro?Glu?Trp?Thr?Arg

20 25 30

cgt?tac?cac?tcc?gtt?gat?cct?gca?gaa?aag?gcc?ttc?ggc?gca?cgc?gca 144

Arg?Tyr?His?Ser?Val?Asp?Pro?Ala?Glu?Lys?Ala?Phe?Gly?Ala?Arg?Ala

35 40 45

gtg?atc?acc?ttc?aag?gat?gga?acc?gtc?gtg?gaa?gat?gaa?ctg?gct?gtg 192

Val?Ile?Thr?Phe?Lys?Asp?Gly?Thr?Val?Val?Glu?Asp?Glu?Leu?Ala?Val

50 55 60

gcg?aat?gcg?cat?cct?ctg?gga?gca?cgg?cct?ttc?gct?agg?gag?cag?tac 240

Ala?Asn?Ala?His?Pro?Leu?Gly?Ala?Arg?Pro?Phe?Ala?Arg?Glu?Gln?Tyr

65 70 75 80

att?cag?aaa?ttc?cgc?acc?ttg?gct?gaa?ggt?gtt?gtg?tcc?gaa?aag?gaa 288

Ile?Gln?Lys?Phe?Arg?Thr?Leu?Ala?Glu?Gly?Val?Val?Ser?Glu?Lys?Glu

85 90 95

cag?gat?cgc?ttc?ttg?gat?gcg?gca?cag?cgt?acg?cac?gag?ctt?gag?gat 336

Gln?Asp?Arg?Phe?Leu?Asp?Ala?Ala?Gln?Arg?Thr?His?Glu?Leu?Glu?Asp

100 105 110

ctt?tca?gaa?ctc?aac?att?gaa?ttg?gat?gcc?gat?att?ttg?gcc?aag?gct 384

Leu?Ser?Glu?Leu?Asn?Ile?Glu?Leu?Asp?Ala?Asp?Ile?Leu?Ala?Lys?Ala

115 120 125

cct?gtg?att?ccg?gaa?gga?ctg?ttc?tgatggcggg?tttgttttcc?tct 431

Pro?Val?Ile?Pro?Glu?Gly?Leu?Phe

130 135

<210>606

<211>136

<212>PRT

＜213〉Corynebacterium glutamicum

<400>606

His?Glu?Arg?Ser?Tyr?Ala?Pro?Glu?Arg?Ala?Leu?Arg?Arg?Glu?Thr?Ile

1 5 10 15

Glu?Leu?Trp?Asn?Lys?Ile?Ser?Thr?Val?Glu?Asp?Pro?Glu?Trp?Thr?Arg

20 25 30

Arg?Tyr?His?Ser?Val?Asp?Pro?Ala?Glu?Lys?Ala?Phe?Gly?Ala?Arg?Ala

35 40 45

Val?Ile?Thr?Phe?Lys?Asp?Gly?Thr?Val?Val?Glu?Asp?Glu?Leu?Ala?Val

50 55 60

Ala?Asn?Ala?His?Pro?Leu?Gly?Ala?Arg?Pro?Phe?Ala?Arg?Glu?Gln?Tyr

65 70 75 80

Ile?Gln?Lys?Phe?Arg?Thr?Leu?Ala?Glu?Gly?Val?Val?Ser?Glu?Lys?Glu

85 90 95

Gln?Asp?Arg?Phe?Leu?Asp?Ala?Ala?Gln?Arg?Thr?His?Glu?Leu?Glu?Asp

100 105 110

Leu?Ser?Glu?Leu?Asn?Ile?Glu?Leu?Asp?Ala?Asp?Ile?Leu?Ala?Lys?Ala

115 120 125

Pro?Val?Ile?Pro?Glu?Gly?Leu?Phe

130 135

<210>607

<211>718

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(718)

<223>RXA00512

<400>607

tacaacgagt?acaacgcttt?cgaccagcaa?gtattcacct?attccgctga?cagctacaag?60

cccatcttct?aacccgccta?tatataagga?gtgaatcacc?atg?tcc?agc?gcc?aca 115

Met?Ser?Ser?Ala?Thr

1 5

acc?act?gat?gtt?cgc?aaa?ggg?ctc?tac?gga?gtc?atc?gcc?gat?tac?acg 163

Thr?Thr?Asp?Val?Arg?Lys?Gly?Leu?Tyr?Gly?Val?Ile?Ala?Asp?Tyr?Thr

10 15 20

gcc?gtt?tcc?aaa?gtc?atg?cca?gag?acc?aat?tca?ctg?acc?tac?cgt?ggc 211

Ala?Val?Ser?Lys?Val?Met?Pro?Glu?Thr?Asn?Ser?Leu?Thr?Tyr?Arg?Gly

25 30 35

tac?gcg?gtg?gaa?gat?ttg?gtg?gaa?aac?tgc?agc?ttc?gag?gag?gtg?ttt 259

Tyr?Ala?Val?Glu?Asp?Leu?Val?Glu?Asn?Cys?Ser?Phe?Glu?Glu?Val?Phe

40 45 50

tac?ctc?ctg?tgg?cac?ggc?gag?ctg?ccc?act?gcg?caa?caa?ctt?gcg?gag 307

Tyr?Leu?Leu?Trp?His?Gly?Glu?Leu?Pro?Thr?Ala?Gln?Gln?Leu?Ala?Glu

55 60 65

ttc?aat?gag?cgt?ggc?cgt?tcc?tac?cgc?tcc?ctg?gat?gcc?ggt?ttg?atc 355

Phe?Asn?Glu?Arg?Gly?Arg?Ser?Tyr?Arg?Ser?Leu?Asp?Ala?Gly?Leu?Ile

70 75 80 85

tcc?ctg?atc?cac?tct?ttg?ccc?aaa?gaa?gcc?cac?ccg?atg?gat?gtt?atg 403

Ser?Leu?Ile?His?Ser?Leu?Pro?Lys?Glu?Ala?His?Pro?Met?Asp?Val?Met

90 95 100

cgc?acc?gcg?gtg?tcc?tac?atg?ggc?acc?aag?gat?tcc?gag?tat?ttc?acc 451

Arg?Thr?Ala?Val?Ser?Tyr?Met?Gly?Thr?Lys?Asp?Ser?Glu?Tyr?Phe?Thr

105 110 115

acc?gat?tct?gag?cac?atc?cgc?aaa?gtt?ggc?cac?acc?ttg?ttg?gcg?cag 499

Thr?Asp?Ser?Glu?His?Ile?Arg?Lys?Val?Gly?His?Thr?Leu?Leu?Ala?Gln

120 125 130

ctt?ccg?atg?gtg?cta?gcc?atg?gat?att?cgt?cgc?cgc?aag?ggc?ctc?gat 547

Leu?Pro?Met?Val?Leu?Ala?Met?Asp?Ile?Arg?Arg?Arg?Lys?Gly?Leu?Asp

135 140 145

atc?atc?gcc?cct?gac?tcc?agc?aag?tca?gtc?gcc?gaa?aac?ctg?ctg?tct 595

Ile?Ile?Ala?Pro?Asp?Ser?Ser?Lys?Ser?Val?Ala?Glu?Asn?Leu?Leu?Ser

150 155 160 165

atg?gtg?ttt?ggt?act?ggc?ccg?gaa?tca?cct?gca?tcc?aac?cca?gct?gac 643

Met?Val?Phe?Gly?Thr?Gly?Pro?Glu?Ser?Pro?Ala?Ser?Asn?Pro?Ala?Asp

170 175 180

gtc?cgc?gat?ttt?gag?aaa?tca?ctg?atc?ctc?tac?gcc?gag?cac?tcc?ttc 691

Val?Arg?Asp?Phe?Glu?Lys?Ser?Leu?Ile?Leu?Tyr?Ala?Glu?His?Ser?Phe

185 190 195

aac?gcc?tcc?acc?ttc?acc?gcc?cgc?gtg 718

Asn?Ala?Ser?Thr?Phe?Thr?Ala?Arg?Val

200 205

<210>608

<211>206

<212>PRT

＜213〉Corynebacterium glutamicum

<400>608

Met?Ser?Ser?Ala?Thr?Thr?Thr?Asp?Val?Arg?Lys?Gly?Leu?Tyr?Gly?Val

1 5 10 15

Ile?Ala?Asp?Tyr?Thr?Ala?Val?Ser?Lys?Val?Met?Pro?Glu?Thr?Asn?Ser

20 25 30

Leu?Thr?Tyr?Arg?Gly?Tyr?Ala?Val?Glu?Asp?Leu?Val?Glu?Asn?Cys?Ser

35 40 45

Phe?Glu?Glu?Val?Phe?Tyr?Leu?Leu?Trp?His?Gly?Glu?Leu?Pro?Thr?Ala

50 55 60

Gln?Gln?Leu?Ala?Glu?Phe?Asn?Glu?Arg?Gly?Arg?Ser?Tyr?Arg?Ser?Leu

65 70 75 80

Asp?Ala?Gly?Leu?Ile?Ser?Leu?Ile?His?Ser?Leu?Pro?Lys?Glu?Ala?His

85 90 95

Pro?Met?Asp?Val?Met?Arg?Thr?Ala?Val?Ser?Tyr?Met?Gly?Thr?Lys?Asp

100 105 110

Ser?Glu?Tyr?Phe?Thr?Thr?Asp?Ser?Glu?His?Ile?Arg?Lys?Val?Gly?His

115 120 125

Thr?Leu?Leu?Ala?Gln?Leu?Pro?Met?Val?Leu?Ala?Met?Asp?Ile?Arg?Arg

130 135 140

Arg?Lys?Gly?Leu?Asp?Ile?Ile?Ala?Pro?Asp?Ser?Ser?Lys?Ser?Val?Ala

145 150 155 160

Glu?Asn?Leu?Leu?Ser?Met?Val?Phe?Gly?Thr?Gly?Pro?Glu?Ser?Pro?Ala

165 170 175

Ser?Asn?Pro?Ala?Asp?Val?Arg?Asp?Phe?Glu?Lys?Ser?Leu?Ile?Leu?Tyr

180 185 190

Ala?Glu?His?Ser?Phe?Asn?Ala?Ser?Thr?Phe?Thr?Ala?Arg?Val

195 200 205

<210>609

<211>320

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(297)

<223>RXA00518

<400>609

gtc?ctt?ccg?gta?tta?gct?gcc?cgc?cac?gac?ggc?gaa?aag?tgg?gtt?gcc 48

Val?Leu?Pro?Val?Leu?Ala?Ala?Arg?His?Asp?Gly?Glu?Lys?Trp?Val?Ala

1 5 10 15

atg?tat?gaa?aac?atg?cgc?gac?gcc?atg?gac?gcc?cgc?acc?ggc?atc?aag 96

Met?Tyr?Glu?Asn?Met?Arg?Asp?Ala?Met?Asp?Ala?Arg?Thr?Gly?Ile?Lys

20 25 30

ccg?aat?ctc?gat?ttc?cct?gct?ggc?cct?gcc?tac?cac?ctg?ctc?ggt?ttc 144

Pro?Asn?Leu?Asp?Phe?Pro?Ala?Gly?Pro?Ala?Tyr?His?Leu?Leu?Gly?Phe

35 40 45

ccg?gtc?gat?ttc?ttc?acc?ccg?ctg?ttc?gtc?atc?gcc?cgc?gtc?gcc?ggc 192

Pro?Val?Asp?Phe?Phe?Thr?Pro?Leu?Phe?Val?Ile?Ala?Arg?Val?Ala?Gly

50 55 60

tgg?acg?gcc?cac?atc?gtg?gag?cag?tac?gaa?aac?aac?tcg?ctc?atc?cgc 240

Trp?Thr?Ala?His?Ile?Val?Glu?Gln?Tyr?Glu?Asn?Asn?Ser?Leu?Ile?Arg

65 70 75 80

cca?ctg?tcc?gag?tac?aac?ggc?gag?gag?cag?cgc?gag?gtc?gcg?ccc?att 288

Pro?Leu?Ser?Glu?Tyr?Asn?Gly?Glu?Glu?Gln?Arg?Glu?Val?Ala?Pro?Ile

85 90 95

gaa?aag?cgc?taaaagattt?tcgcttttcg?acg 320

Glu?Lys?Arg

<210>610

<211>99

<212>PRT

＜213〉Corynebacterium glutamicum

<400>610

Val?Leu?Pro?Val?Leu?Ala?Ala?Arg?His?Asp?Gly?Glu?Lys?Trp?Val?Ala

1 5 10 15

Met?Tyr?Glu?Asn?Met?Arg?Asp?Ala?Met?Asp?Ala?Arg?Thr?Gly?Ile?Lys

20 25 30

Pro?Asn?Leu?Asp?Phe?Pro?Ala?Gly?Pro?Ala?Tyr?His?Leu?Leu?Gly?Phe

35 40 45

Pro?Val?Asp?Phe?Phe?Thr?Pro?Leu?Phe?Val?Ile?Ala?Arg?Val?Ala?Gly

50 55 60

Trp?Thr?Ala?His?Ile?Val?Glu?Gln?Tyr?Glu?Asn?Asn?Ser?Leu?Ile?Arg

65 70 75 80

Pro?Leu?Ser?Glu?Tyr?Asn?Gly?Glu?Glu?Gln?Arg?Glu?Val?Ala?Pro?Ile

85 90 95

Glu?Lys?Arg

<210>611

<211>1494

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1471)

<223>RXA01077

<400>611

tctatgactt?gatccacaat?gtgatgcaaa?tcattgaccc?tcaccccgga?ccaagcgctt?60

aatgaaggca?agccaaactt?aactagtaga?taggattgca?atg?acc?gaa?tcg?caa 115

Met?Thr?Glu?Ser?Gln

1 5

gat?ctc?gcc?gca?ttc?gtg?gaa?gct?gcc?aaa?ctc?aat?gat?gca?agc?ccc 163

Asp?Leu?Ala?Ala?Phe?Val?Glu?Ala?Ala?Lys?Leu?Asn?Asp?Ala?Ser?Pro

10 15 20

gaa?gcc?gta?gag?caa?ttg?aaa?atc?aga?gtg?cta?gac?acc?gta?ggc?gtt 211

Glu?Ala?Val?Glu?Gln?Leu?Lys?Ile?Arg?Val?Leu?Asp?Thr?Val?Gly?Val

25 30 35

gcc?att?ggc?gca?ctg?gat?gcc?gaa?ccg?att?gtc?gcc?att?cga?gga?ctc 259

Ala?Ile?Gly?Ala?Leu?Asp?Ala?Glu?Pro?Ile?Val?Ala?Ile?Arg?Gly?Leu

40 45 50

ctg?gaa?gac?ctc?ggg?gga?acc?gaa?cag?tca?aca?ctt?att?ggt?ggt?ggc 307

Leu?Glu?Asp?Leu?Gly?Gly?Thr?Glu?Gln?Ser?Thr?Leu?Ile?Gly?Gly?Gly

55 60 65

aaa?acc?agt?ccg?gaa?cgt?gca?gca?ttt?ttc?aac?agc?gca?tta?agc?cgc 355

Lys?Thr?Ser?Pro?Glu?Arg?Ala?Ala?Phe?Phe?Asn?Ser?Ala?Leu?Ser?Arg

70 75 80 85

tac?ctc?gac?ttc?atg?gac?gcc?tac?cta?gca?aag?ggc?gaa?acc?aac?cac 403

Tyr?Leu?Asp?Phe?Met?Asp?Ala?Tyr?Leu?Ala?Lys?Gly?Glu?Thr?Asn?His

90 95 100

ccc?tcg?gat?aac?ttc?gga?gca?gtg?ctc?gct?gca?gcc?gaa?agc?gtt?ggc 451

Pro?Ser?Asp?Asn?Phe?Gly?Ala?Val?Leu?Ala?Ala?Ala?Glu?Ser?Val?Gly

105 110 115

gcc?tct?gga?aaa?gac?ctg?ctc?acc?gca?ttc?gcc?gtg?gcc?tac?cag?gta 499

Ala?Ser?Gly?Lys?Asp?Leu?Leu?Thr?Ala?Phe?Ala?Val?Ala?Tyr?Gln?Val

120 125 130

cac?acc?aga?ctt?tca?gat?gtc?gca?cca?gtt?cgc?gcc?aaa?ggt?ttc?gat 547

His?Thr?Arg?Leu?Ser?Asp?Val?Ala?Pro?Val?Arg?Ala?Lys?Gly?Phe?Asp

135 140 145

cac?acc?acc?caa?gga?gca?ttc?gca?gcg?ggc?gca?tct?gct?gcc?aag?gca 595

His?Thr?Thr?Gln?Gly?Ala?Phe?Ala?Ala?Gly?Ala?Ser?Ala?Ala?Lys?Ala

150 155 160 165

ctg?ggt?ttg?cca?gct?gat?caa?atc?gcc?aac?gca?ctg?gcc?atc?gca?gga 643

Leu?Gly?Leu?Pro?Ala?Asp?Gln?Ile?Ala?Asn?Ala?Leu?Ala?Ile?Ala?Gly

170 175 180

aca?gcc?aat?gtt?gca?ctt?cgt?gtc?act?cgc?act?gga?aac?ttg?agc?cac 691

Thr?Ala?Asn?Val?Ala?Leu?Arg?Val?Thr?Arg?Thr?Gly?Asn?Leu?Ser?His

185 190 195

tgg?aaa?ggc?ctt?gcc?tac?cca?cac?gtg?tcc?aaa?gaa?gga?acc?tgg?gca 739

Trp?Lys?Gly?Leu?Ala?Tyr?Pro?His?Val?Ser?Lys?Glu?Gly?Thr?Trp?Ala

200 205 210

gca?ctg?ctc?gca?agc?cga?ggt?att?acc?ggt?ccg?gaa?gaa?gtc?ttc?gaa 787

Ala?Leu?Leu?Ala?Ser?Arg?Gly?Ile?Thr?Gly?Pro?Glu?Glu?Val?Phe?Glu

215 220 225

ggc?aac?aag?gga?ttc?aaa?gag?tcc?gtc?tcc?gga?ccg?ttc?gag?atc?gat 835

Gly?Asn?Lys?Gly?Phe?Lys?Glu?Ser?Val?Ser?Gly?Pro?Phe?Glu?Ile?Asp

230 235 240 245

tgg?tcc?aag?gaa?gac?ttg?gaa?agc?gtt?aag?cgc?acc?atc?atc?aag?aaa 883

Trp?Ser?Lys?Glu?Asp?Leu?Glu?Ser?Val?Lys?Arg?Thr?Ile?Ile?Lys?Lys

250 255 260

cac?aac?gcg?gaa?att?cac?tcg?cag?tca?gcg?ctt?gat?gca?gcc?caa?gaa 931

His?Asn?Ala?Glu?Ile?His?Ser?Gln?Ser?Ala?Leu?Asp?Ala?Ala?Gln?Glu

265 270 275

ata?cgc?gca?caa?gaa?ggc?ttc?aat?gtg?gac?aac?att?gaa?aag?att?cac 979

Ile?Arg?Ala?Gln?Glu?Gly?Phe?Asn?Val?Asp?Asn?Ile?Glu?Lys?Ile?His

280 285 290

ctg?act?act?ttc?gac?gtt?gcc?tac?tcc?atc?att?ggc?ggc?ggc?gaa?gaa 1027

Leu?Thr?Thr?Phe?Asp?Val?Ala?Tyr?Ser?Ile?Ile?Gly?Gly?Gly?Glu?Glu

295 300 305

ggc?gac?aaa?cag?ctt?att?cgc?acc?aaa?gaa?gaa?gcc?gat?cac?tca?ctg 1075

Gly?Asp?Lys?Gln?Leu?Ile?Arg?Thr?Lys?Glu?Glu?Ala?Asp?His?Ser?Leu

310 315 320 325

ccg?tgg?atg?ctc?gct?gta?gtt?ctg?ctg?gat?ggt?cag?ctc?aat?ccc?gaa 1123

Pro?Trp?Met?Leu?Ala?Val?Val?Leu?Leu?Asp?Gly?Gln?Leu?Asn?Pro?Glu

330 335 340

cag?tac?gaa?cca?tca?cgc?atc?gtt?gct?gat?gat?gta?caa?acc?ttg?atg 1171

Gln?Tyr?Glu?Pro?Ser?Arg?Ile?Val?Ala?Asp?Asp?Val?Gln?Thr?Leu?Met

345 350 355

aag?aaa?atc?gaa?atc?aca?ccg?tca?gat?gaa?ttc?tct?gat?cgc?ttc?cct 1219

Lys?Lys?Ile?Glu?Ile?Thr?Pro?Ser?Asp?Glu?Phe?Ser?Asp?Arg?Phe?Pro

360 365 370

gac?cac?atg?cca?gct?gat?cta?gaa?gtc?aca?cta?aac?gat?ggc?tcg?gtg 1267

Asp?His?Met?Pro?Ala?Asp?Leu?Glu?Val?Thr?Leu?Asn?Asp?Gly?Ser?Val

375 380 385

ttc?aaa?gct?tca?caa?gat?agc?tac?tta?ggc?ttc?cac?gac?aat?ccc?cta 1315

Phe?Lys?Ala?Ser?Gln?Asp?Ser?Tyr?Leu?Gly?Phe?His?Asp?Asn?Pro?Leu

390 395 400 405

gat?tgg?gac?aac?gcg?cgc?aag?aaa?ttc?gat?gcc?ctt?gtc?aca?cca?ttc 1363

Asp?Trp?Asp?Asn?Ala?Arg?Lys?Lys?Phe?Asp?Ala?Leu?Val?Thr?Pro?Phe

410 415 420

acc?ggt?gaa?gaa?cta?cgt?gaa?gaa?atc?gcc?acg?atc?att?cac?gag?ctc 1411

Thr?Gly?Glu?Glu?Leu?Arg?Glu?Glu?Ile?Ala?Thr?Ile?Ile?His?Glu?Leu

425 430 435

gat?agc?cga?cag?gtt?tct?gaa?ctc?aca?gaa?gcc?ctg?gcc?aaa?gtc?tcc 1459

Asp?Ser?Arg?Gln?Val?Ser?Glu?Leu?Thr?Glu?Ala?Leu?Ala?Lys?Val?Ser

440 445 450

acc?acc?cgc?agc?taaaactttt?tgaaaggagc?tca 1494

Thr?Thr?Arg?Ser

455

<210>612

<211>457

<212>PRT

＜213〉Corynebacterium glutamicum

<400>612

Met?Thr?Glu?Ser?Gln?Asp?Leu?Ala?Ala?Phe?Val?Glu?Ala?Ala?Lys?Leu

1 5 10 15

Asn?Asp?Ala?Ser?Pro?Glu?Ala?Val?Glu?Gln?Leu?Lys?Ile?Arg?Val?Leu

20 25 30

Asp?Thr?Val?Gly?Val?Ala?Ile?Gly?Ala?Leu?Asp?Ala?Glu?Pro?Ile?Val

35 40 45

Ala?Ile?Arg?Gly?Leu?Leu?Glu?Asp?Leu?Gly?Gly?Thr?Glu?Gln?Ser?Thr

50 55 60

Leu?Ile?Gly?Gly?Gly?Lys?Thr?Ser?Pro?Glu?Arg?Ala?Ala?Phe?Phe?Asn

65 70 75 80

Ser?Ala?Leu?Ser?Arg?Tyr?Leu?Asp?Phe?Met?Asp?Ala?Tyr?Leu?Ala?Lys

85 90 95

Gly?Glu?Thr?Asn?His?Pro?Ser?Asp?Asn?Phe?Gly?Ala?Val?Leu?Ala?Ala

100 105 110

Ala?Glu?Ser?Val?Gly?Ala?Ser?Gly?Lys?Asp?Leu?Leu?Thr?Ala?Phe?Ala

115 120 125

Val?Ala?Tyr?Gln?Val?His?Thr?Arg?Leu?Ser?Asp?Val?Ala?Pro?Val?Arg

130 135 140

Ala?Lys?Gly?Phe?Asp?His?Thr?Thr?Gln?Gly?Ala?Phe?Ala?Ala?Gly?Ala

145 150 155 160

Ser?Ala?Ala?Lys?Ala?Leu?Gly?Leu?Pro?Ala?Asp?Gln?Ile?Ala?Asn?Ala

165 170 175

Leu?Ala?Ile?Ala?Gly?Thr?Ala?Asn?Val?Ala?Leu?Arg?Val?Thr?Arg?Thr

180 185 190

Gly?Asn?Leu?Ser?His?Trp?Lys?Gly?Leu?Ala?Tyr?Pro?His?Val?Ser?Lys

195 200 205

Glu?Gly?Thr?Trp?Ala?Ala?Leu?Leu?Ala?Ser?Arg?Gly?Ile?Thr?Gly?Pro

210 215 220

Glu?Glu?Val?Phe?Glu?Gly?Asn?Lys?Gly?Phe?Lys?Glu?Ser?Val?Ser?Gly

225 230 235 240

Pro?Phe?Glu?Ile?Asp?Trp?Ser?Lys?Glu?Asp?Leu?Glu?Ser?Val?Lys?Arg

245 250 255

Thr?Ile?Ile?Lys?Lys?His?Asn?Ala?Glu?Ile?His?Ser?Gln?Ser?Ala?Leu

260 265 270

Asp?Ala?Ala?Gln?Glu?Ile?Arg?Ala?Gln?Glu?Gly?Phe?Asn?Val?Asp?Asn

275 280 285

Ile?Glu?Lys?Ile?His?Leu?Thr?Thr?Phe?Asp?Val?Ala?Tyr?Ser?Ile?Ile

290 295 300

Gly?Gly?Gly?Glu?Glu?Gly?Asp?Lys?Gln?Leu?Ile?Arg?Thr?Lys?Glu?Glu

305 310 315 320

Ala?Asp?His?Ser?Leu?Pro?Trp?Met?Leu?Ala?Val?Val?Leu?Leu?Asp?Gly

325 330 335

Gln?Leu?Asn?Pro?Glu?Gln?Tyr?Glu?Pro?Ser?Arg?Ile?Val?Ala?Asp?Asp

340 345 350

Val?Gln?Thr?Leu?Met?Lys?Lys?Ile?Glu?Ile?Thr?Pro?Ser?Asp?Glu?Phe

355 360 365

Ser?Asp?Arg?Phe?Pro?Asp?His?Met?Pro?Ala?Asp?Leu?Glu?Val?Thr?Leu

370 375 380

Asn?Asp?Gly?Ser?Val?Phe?Lys?Ala?Ser?Gln?Asp?Ser?Tyr?Leu?Gly?Phe

385 390 395 400

His?Asp?Asn?Pro?Leu?Asp?Trp?Asp?Asn?Ala?Arg?Lys?Lys?Phe?Asp?Ala

405 410 415

Leu?Val?Thr?Pro?Phe?Thr?Gly?Glu?Glu?Leu?Arg?Glu?Glu?Ile?Ala?Thr

420 425 430

Ile?Ile?His?Glu?Leu?Asp?Ser?Arg?Gln?Val?Ser?Glu?Leu?Thr?Glu?Ala

435 440 445

Leu?Ala?Lys?Val?Ser?Thr?Thr?Arg?Ser

450 455

<210>613

<211>923

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(900)

<223>RXN03144

<400>613

acc?acg?acg?gct?acc?agg?cag?tcg?cga?aaa?ggt?gag?att?tcc?agc?tgg 48

Thr?Thr?Thr?Ala?Thr?Arg?Gln?Ser?Arg?Lys?Gly?Glu?Ile?Ser?Ser?Trp

1 5 10 15

aag?gcg?ttc?gcg?cca?gcg?ttt?gcg?gga?aag?atg?gcc?att?gag?gcg?atg 96

Lys?Ala?Phe?Ala?Pro?Ala?Phe?Ala?Gly?Lys?Met?Ala?Ile?Glu?Ala?Met

20 25 30

gat?cgt?gcg?atg?cgt?ggg?gag?ggt?tcg?ccc?gca?ccg?att?tgg?gag?ggc 144

Asp?Arg?Ala?Met?Arg?Gly?Glu?Gly?Ser?Pro?Ala?Pro?Ile?Trp?Glu?Gly

35 40 45

gaa?gac?ggg?gtc?atc?gcg?tgg?ctg?tta?tcg?ggc?aaa?gat?cat?gtt?tat 192

Glu?Asp?Gly?Val?Ile?Ala?Trp?Leu?Leu?Ser?Gly?Lys?Asp?His?Val?Tyr

50 55 60

cat?gtg?cca?ttg?ccg?gaa?cac?ggc?gag?ccc?aag?ctg?ggg?att?cta?gag 240

His?Val?Pro?Leu?Pro?Glu?His?Gly?Glu?Pro?Lys?Leu?Gly?Ile?Leu?Glu

65 70 75 80

act?tac?aca?aag?gaa?cat?tca?gcg?gaa?tat?caa?tcg?cag?gca?ccg?att 288

Thr?Tyr?Thr?Lys?Glu?His?Ser?Ala?Glu?Tyr?Gln?Ser?Gln?Ala?Pro?Ile

85 90 95

gat?ctg?gcg?cgc?agg?atg?aag?cca?ctg?gtt?gac?gcg?gct?ggc?gga?acg 336

Asp?Leu?Ala?Arg?Arg?Met?Lys?Pro?Leu?Val?Asp?Ala?Ala?Gly?Gly?Thr

100 105 110

gaa?cac?att?gca?gag?att?gtg?ctg?cgc?acc?agt?cac?cac?acg?cat?tat 384

Glu?His?Ile?Ala?Glu?Ile?Val?Leu?Arg?Thr?Ser?His?His?Thr?His?Tyr

115 120 125

gtg?att?ggc?act?ggg?gcg?aac?gat?ccg?cag?aag?atg?gat?ccg?cag?gcc 432

Val?Ile?Gly?Thr?Gly?Ala?Asn?Asp?Pro?Gln?Lys?Met?Asp?Pro?Gln?Ala

130 135 140

tcg?cgt?gaa?acc?ctg?gat?cat?tcc?atc?atg?tac?att?ttc?gcc?gtc?gcg 480

Ser?Arg?Glu?Thr?Leu?Asp?His?Ser?Ile?Met?Tyr?Ile?Phe?Ala?Val?Ala

145 150 155 160

ctt?caa?gat?ggc?gtg?tgg?cac?cac?gag?ttt?tcc?tac?acc?cgc?aag?cgt 528

Leu?Gln?Asp?Gly?Val?Trp?His?His?Glu?Phe?Ser?Tyr?Thr?Arg?Lys?Arg

165 170 175

tcc?acc?cgc?ccg?gaa?act?gtg?gag?ctg?tgg?cac?aag?att?cgc?acc?gtg 576

Ser?Thr?Arg?Pro?Glu?Thr?Val?Glu?Leu?Trp?His?Lys?Ile?Arg?Thr?Val

180 185 190

gag?gat?cct?gaa?tgg?acg?cgc?cga?tac?cat?tct?gat?gat?cct?gca?aaa 624

Glu?Asp?Pro?Glu?Trp?Thr?Arg?Arg?Tyr?His?Ser?Asp?Asp?Pro?Ala?Lys

195 200 205

aag?gcc?ttt?ggt?gcg?aaa?gca?gtg?atc?aca?atg?gct?gat?ggc?acc?gtg 672

Lys?Ala?Phe?Gly?Ala?Lys?Ala?Val?Ile?Thr?Met?Ala?Asp?Gly?Thr?Val

210 215 220

att?gag?gat?gaa?ttg?gct?gtc?gcg?gat?gcc?cac?ccg?ctg?ggt?gct?cgg 720

Ile?Glu?Asp?Glu?Leu?Ala?Val?Ala?Asp?Ala?His?Pro?Leu?Gly?Ala?Arg

225 230 235 240

ccg?ttt?gcg?cgg?gag?aat?tac?att?gaa?aaa?ttc?cgc?aca?ctc?gcg?cag 768

Pro?Phe?Ala?Arg?Glu?Asn?Tyr?Ile?Glu?Lys?Phe?Arg?Thr?Leu?Ala?Gln

245 250 255

ggg?att?gtc?att?gat?tca?gaa?cag?gaa?cgc?ttc?ttg?cat?gcc?gtg?caa 816

Gly?Ile?Val?Ile?Asp?Ser?Glu?Gln?Glu?Arg?Phe?Leu?His?Ala?Val?Gln

260 265 270

agc?ctg?cct?gac?ctg?gat?gat?ctt?gat?cag?ctc?aac?atc?gaa?gtc?gac 864

Ser?Leu?Pro?Asp?Leu?Asp?Asp?Leu?Asp?Gln?Leu?Asn?Ile?Glu?Val?Asp

275 280 285

ata?agc?aac?cag?gcc?gcg?acg?aaa?gcg?ggg?ctg?tta?tgaatctctt 910

Ile?Ser?Asn?Gln?Ala?Ala?Thr?Lys?Ala?Gly?Leu?Leu

290 295 300

ttcgaatggt?gtt 923

<210>614

<211>300

<212>PRT

＜213〉Corynebacterium glutamicum

<400>?614

Thr?Thr?Thr?Ala?Thr?Arg?Gln?Ser?Arg?Lys?Gly?Glu?Ile?Scr?Ser?Trp

1 5 10 15

Lys?Ala?Phe?Ala?Pro?Ala?Phe?Ala?Gly?Lys?Met?Ala?Ile?Glu?Ala?Met

20 25 30

Asp?Arg?Ala?Met?Arg?Gly?Glu?Gly?Ser?Pro?Ala?Pro?Ile?Trp?Glu?Gly

35 40 45

Glu?Asp?Gly?Val?Ile?Ala?Trp?Leu?Leu?Ser?Gly?Lys?Asp?His?Val?Tyr

50 55 60

His?Val?Pro?Leu?Pro?Glu?His?Gly?Glu?Pro?Lys?Leu?Gly?Ile?Leu?Glu

65 70 75 80

Thr?Tyr?Thr?Lys?Glu?His?Ser?Ala?Glu?Tyr?Gln?Ser?Gln?Ala?Pro?Ile

85 90 95

Asp?Leu?Ala?Arg?Arg?Met?Lys?Pro?Leu?Val?Asp?Ala?Ala?Gly?Gly?Thr

100 105 110

Glu?His?Ile?Ala?Glu?Ile?Val?Leu?Arg?Thr?Ser?His?His?Thr?His?Tyr

115 120 125

Val?Ile?Gly?Thr?Gly?Ala?Asn?Asp?Pro?Gln?Lys?Met?Asp?Pro?Gln?Ala

130 135 140

Ser?Arg?Glu?Thr?Leu?Asp?His?Ser?Ile?Met?Tyr?Ile?Phe?Ala?Val?Ala

145 150 155 160

Leu?Gln?Asp?Gly?Val?Trp?His?His?Glu?Phe?Ser?Tyr?Thr?Arg?Lys?Arg

165 170 175

Ser?Thr?Arg?Pro?Glu?Thr?Val?Glu?Leu?Trp?His?Lys?Ile?Arg?Thr?Val

180 185 190

Glu?Asp?Pro?Glu?Trp?Thr?Arg?Arg?Tyr?His?Ser?Asp?Asp?Pro?Ala?Lys

195 200 205

Lys?Ala?Phe?Gly?Ala?Lys?Ala?Val?Ile?Thr?Met?Ala?Asp?Gly?Thr?Val

210 215 220

Ile?Glu?Asp?Glu?Leu?Ala?Val?Ala?Asp?Ala?His?Pro?Leu?Gly?Ala?Arg

225 230 235 240

Pro?Phe?Ala?Arg?Glu?Asn?Tyr?Ile?Glu?Lys?Phe?Arg?Thr?Leu?Ala?Gln

245 250 255

Gly?Ile?Val?Ile?Asp?Ser?Glu?Gln?Glu?Arg?Phe?Leu?His?Ala?Val?Gln

260 265 270

Ser?Leu?Pro?Asp?Leu?Asp?Asp?Leu?Asp?Gln?Leu?Asn?Ile?Glu?Val?Asp

275 280 285

Ile?Ser?Asn?Gln?Ala?Ala?Thr?Lys?Ala?Gly?Leu?Leu

290 295 300

<210>615

<211>511

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(511)

<223>FRXA02322

<400>615

cgcgcagagc?taaactgcgt?gaggttgtgg?cctgtcacac?ataatcggcc?tagggtggga?60

ctttaaggaa?acagtgcaca?aataaatctc?aaggagcccc?atg?cgc?atc?cac?gat 115

Met?Arg?Ile?His?Asp

1 5

gtt?tat?acc?cac?ctt?tcg?gcc?gat?aac?ttt?ccc?aaa?gca?gag?cac?ctt 163

Val?Tyr?Thr?His?Leu?Ser?Ala?Asp?Asn?Phe?Pro?Lys?Ala?Glu?His?Leu

10 15 20

gcg?tgg?aaa?ttc?tcc?gag?ctt?gcc?acc?gac?ccc?gtg?gag?gtg?aca?ccg 211

Ala?Trp?Lys?Phe?Ser?Glu?Leu?Ala?Thr?Asp?Pro?Val?Glu?Val?Thr?Pro

25 30 35

gat?gtt?tcg?gag?atg?atc?atc?aac?cgg?atc?atc?gac?aac?gcg?gcg?gtg 259

Asp?Val?Ser?Glu?Met?Ile?Ile?Asn?Arg?Ile?Ile?Asp?Asn?Ala?Ala?Val

40 45 50

tct?gcc?gcg?tcg?gtg?ttg?cgc?cgg?cct?gtg?act?gtg?gcc?agg?caa?caa 307

Ser?Ala?Ala?Ser?Val?Leu?Arg?Arg?Pro?Val?Thr?Val?Ala?Arg?Gln?Gln

55 60 65

gcg?cag?tcc?cat?ccg?cgg?gaa?aag?ggc?gga?aaa?gtt?ttt?gga?att?tca 355

Ala?Gln?Ser?His?Pro?Arg?Glu?Lys?Gly?Gly?Lys?Val?Phe?Gly?Ile?Ser

70 75 80 85

ggc?agc?tac?tca?cca?gag?tgg?gct?gcc?ttt?gct?aat?ggt?gtg?gcc?gta 403

Gly?Ser?Tyr?Ser?Pro?Glu?Trp?Ala?Ala?Phe?Ala?Asn?Gly?Val?Ala?Val

90 95 100

cgt?gaa?ttg?gac?ttc?cac?gat?aca?ttt?tta?gca?gct?gaa?tac?tcc?cat 451

Arg?Glu?Leu?Asp?Phe?His?Asp?Thr?Phe?Leu?Ala?Ala?Glu?Tyr?Ser?His

105 110 115

ccc?ggc?gac?aat?att?cca?cca?ctt?ctt?gca?gta?gcg?cag?gct?cag?aga 499

Pro?Gly?Asp?Asn?Ile?Pro?Pro?Leu?Leu?Ala?Val?Ala?Gln?Ala?Gln?Arg

120 125 130

agc?agc?ggc?agg 511

Ser?Ser?Gly?Arg

135

<210>616

<211>137

<212>PRT

＜213〉Corynebacterium glutamicum

<400>616

Met?Arg?Ile?His?Asp?Val?Tyr?Thr?His?Leu?Ser?Ala?Asp?Asn?Phe?Pro

1 5 10 15

Lys?Ala?Glu?His?Leu?Ala?Trp?Lys?Phe?Ser?Glu?Leu?Ala?Thr?Asp?Pro

20 25 30

Val?Glu?Val?Thr?Pro?Asp?Val?Ser?Glu?Met?Ile?Ile?Asn?Arg?Ile?Ile

35 40 45

Asp?Asn?Ala?Ala?Val?Ser?Ala?Ala?Ser?Val?Leu?Arg?Arg?Pro?Val?Thr

50 55 60

Val?Ala?Arg?Gln?Gln?Ala?Gln?Ser?His?Pro?Arg?Glu?Lys?Gly?Gly?Lys

65 70 75 80

Val?Phe?Gly?Ile?Ser?Gly?Ser?Tyr?Ser?Pro?Glu?Trp?Ala?Ala?Phe?Ala

85 90 95

Asn?Gly?Val?Ala?Val?Arg?Glu?Leu?Asp?Phe?His?Asp?Thr?Phe?Leu?Ala

100 105 110

Ala?Glu?Tyr?Ser?His?Pro?Gly?Asp?Asn?Ile?Pro?Pro?Leu?Leu?Ala?Val

115 120 125

Ala?Gln?Ala?Gln?Arg?Ser?Ser?Gly?Arg

130 135

<210>617

<211>603

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(603)

<223>RXA02329

<400>617

acg?gct?acc?agg?cag?tcg?cga?aaa?ggt?gag?att?tcc?agc?tgg?aag?gcg 48

Thr?Ala?Thr?Arg?Gln?Ser?Arg?Lys?Gly?Glu?Ile?Ser?Ser?Trp?Lys?Ala

1 5 10 15

ttc?gcg?cca?gcg?ttt?gcg?gga?aag?atg?gcc?att?gag?gcg?atg?gat?cgt 96

Phe?Ala?Pro?Ala?Phe?Ala?Gly?Lys?Met?Ala?Ile?Glu?Ala?Met?Asp?Arg

20 25 30

gcg?atg?cgt?ggg?gag?ggt?tcg?ccc?gca?ccg?att?tgg?gag?ggc?gaa?gac 144

Ala?Met?Arg?Gly?Glu?Gly?Ser?Pro?Ala?Pro?Ile?Trp?Glu?Gly?Glu?Asp

35 40 45

ggg?gtc?atc?gcg?tgg?ctg?tta?tcg?ggc?aaa?gat?cat?gtt?tat?cat?gtg 192

Gly?Val?Ile?Ala?Trp?Leu?Leu?Ser?Gly?Lys?Asp?His?Val?Tyr?His?Val

50 55 60

cca?ttg?ccg?gaa?cac?ggc?gag?ccc?aag?ctg?ggg?att?cta?gag?act?tac 240

Pro?Leu?Pro?Glu?His?Gly?Glu?Pro?Lys?Leu?Gly?Ile?Leu?Glu?Thr?Tyr

65 70 75 80

aca?aag?gaa?cat?tca?gcg?gaa?tat?caa?tcg?cag?gca?ccg?att?gat?ctg 288

Thr?Lys?Glu?His?Ser?Ala?Glu?Tyr?Gln?Ser?Gln?Ala?Pro?Ile?Asp?Leu

85 90 95

gcg?cgc?agg?atg?aag?cca?ctg?gtt?gac?gcg?gct?ggc?gga?acg?gaa?cac 336

Ala?Arg?Arg?Met?Lys?Pro?Leu?Val?Asp?Ala?Ala?Gly?Gly?Thr?Glu?His

100 105 l10

att?gca?gag?att?gtg?ctg?cgc?acc?agt?cac?cac?acg?cat?tat?gtg?att 384

Ile?Ala?Glu?Ile?Val?Leu?Arg?Thr?Ser?His?His?Thr?His?Tyr?Val?Ile

115 120 125

ggc?act?ggg?gcg?aac?gat?ccg?cag?aag?atg?gat?ccg?cag?gcc?tcg?cgt 432

Gly?Thr?Gly?Ala?Asn?Asp?Pro?Gln?Lys?Met?Asp?Pro?Gln?Ala?Ser?Arg

130 135 140

gaa?acc?ctg?gat?cat?tcc?atc?atg?tac?att?ttc?gcc?gtc?gcg?ctt?caa 480

Glu?Thr?Leu?Asp?His?Ser?Ile?Met?Tyr?Ile?Phe?Ala?Val?Ala?Leu?Gln

145 150 155 160

gat?ggc?gtg?tgg?cac?cac?gag?ttt?tcc?tac?acc?cgc?aag?cgt?tcc?acc 528

Asp?Gly?Val?Trp?His?His?Glu?Phe?Ser?Tyr?Thr?Arg?Lys?Arg?Ser?Thr

165 170 175

cgc?ccg?gaa?act?gtg?gag?ctg?tgg?cac?aag?att?cgc?acc?gtg?gag?gat 576

Arg?Pro?Glu?Thr?Val?Glu?Leu?Trp?His?Lys?Ile?Arg?Thr?Val?Glu?Asp

180 185 190

cct?gaa?tgg?acg?cgc?cga?tac?cat?tct 603

Pro?Glu?Trp?Thr?Arg?Arg?Tyr?His?Ser

195 200

<210>618

<211>201

<212>PRT

＜213〉Corynebacterium glutamicum

<400>618

Thr?Ala?Thr?Arg?Gln?Ser?Arg?Lys?Gly?Glu?Ile?Ser?Ser?Trp?Lys?Ala

1 5 10 15

Phe?Ala?Pro?Ala?Phe?Ala?Gly?Lys?Met?Ala?Ile?Glu?Ala?Met?Asp?Arg

20 25 30

Ala?Met?Arg?Gly?Glu?Gly?Ser?Pro?Ala?Pro?Ile?Trp?Glu?Gly?Glu?Asp

35 40 45

Gly?Val?Ile?Ala?Trp?Leu?Leu?Ser?Gly?Lys?Asp?His?Val?Tyr?His?Val

50 55 60

Pro?Leu?Pro?Glu?His?Gly?Glu?Pro?Lys?Leu?Gly?Ile?Leu?Glu?Thr?Tyr

65 70 75 80

Thr?Lys?Glu?His?Ser?Ala?Glu?Tyr?Gln?Ser?Gln?Ala?Pro?Ile?Asp?Leu

85 90 95

Ala?Arg?Arg?Met?Lys?Pro?Leu?Val?Asp?Ala?Ala?Gly?Gly?Thr?Glu?His

100 105 110

Ile?Ala?Glu?Ile?Val?Leu?Arg?Thr?Ser?His?His?Thr?His?Tyr?Val?Ile

115 120 125

Gly?Thr?Gly?Ala?Asn?Asp?Pro?Gln?Lys?Met?Asp?Pro?Gln?Ala?Ser?Arg

130 135 140

Glu?Thr?Leu?Asp?His?Ser?Ile?Met?Tyr?Ile?Phe?Ala?Val?Ala?Leu?Gln

145 150 155 160

Asp?Gly?Val?Trp?His?His?Glu?Phe?Ser?Tyr?Thr?Arg?Lys?Arg?Ser?Thr

165 170 175

Arg?Pro?Glu?Thr?Val?Glu?Leu?Trp?His?Lys?Ile?Arg?Thr?Val?Glu?Asp

180 185 190

Pro?Glu?Trp?Thr?Arg?Arg?Tyr?His?Ser

195 200

<210>619

<211>1266

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1243)

<223>RXA02332

<400>619

gaccgcatgc?aacaccgcag?cagattatat?gagctcctgc?gatacgaaga?ctacaacgtc?60

tttgaccagc?acattttcac?ctacagaaaa?ggagaaaaca?atg?agt?gac?agc?caa 115

Met?Ser?Asp?Ser?Gln

1 5

gtc?cgc?aaa?gga?ctc?aac?ggc?gtc?atc?tct?gac?tac?aca?agc?att?tcc 163

Val?Arg?Lys?Gly?Leu?Asn?Gly?Val?Ile?Ser?Asp?Tyr?Thr?Ser?Ile?Ser

10 15 20

aaa?gtg?atg?cca?gag?agc?aac?tcg?ctg?act?tac?cgt?ggc?tac?gcc?gtg 211

Lys?Val?Met?Pro?Glu?Ser?Asn?Ser?Leu?Thr?Tyr?Arg?Gly?Tyr?Ala?Val

25 30 35

gag?gat?ttg?gtg?gaa?aac?tgc?agc?ttt?gaa?gaa?gtg?atc?tac?ctc?ctg 259

Glu?Asp?Leu?Val?Glu?Asn?Cys?Ser?Phe?Glu?Glu?Val?Ile?Tyr?Leu?Leu

40 45 50

tgg?ttt?ggg?gag?ctg?ccc?acc?act?gaa?caa?ctc?cgg?acc?ttc?aac?acg 307

Trp?Phe?Gly?Glu?Leu?Pro?Thr?Thr?Glu?Gln?Leu?Arg?Thr?Phe?Asn?Thr

55 60 65

aca?ggt?cga?agc?tac?cgc?tca?ctc?gac?gcc?gga?ctg?att?tcc?ctc?atc 355

Thr?Gly?Arg?Ser?Tyr?Arg?Ser?Leu?Asp?Ala?Gly?Leu?Ile?Ser?Leu?Ile

70 75 80 85

cac?tcc?tta?ccc?aac?acc?tgc?cac?ccc?atg?gac?gtg?ctg?cgc?acc?gca 403

His?Ser?Leu?Pro?Asn?Thr?Cys?His?Pro?Met?Asp?Val?Leu?Arg?Thr?Ala

90 95 100

gtg?tcc?tac?atg?ggt?acc?ttt?gat?ccc?gat?ccg?ttt?acc?cgc?gat?gcc 451

Val?Ser?Tyr?Met?Gly?Thr?Phe?Asp?Pro?Asp?Pro?Phe?Thr?Arg?Asp?Ala

105 110 115

gat?cat?atc?cga?agc?att?gga?cac?aac?ctg?ctt?gcg?cag?ctt?ccc?atg 499

Asp?His?Ile?Arg?Ser?Ile?Gly?His?Asn?Leu?Leu?Ala?Gln?Leu?Pro?Met

120 125 130

gtg?gtt?gcc?atg?gat?atc?cgc?agg?cga?agt?ggg?gaa?gag?atc?atc?gca 547

Val?Val?Ala?Met?Asp?Ile?Arg?Arg?Arg?Ser?Gly?Glu?Glu?Ile?Ile?Ala

135 140 145

cct?gac?cac?aac?aaa?ggt?atc?gct?tcg?aat?ttc?tta?tcc?atg?gtg?ttt 595

Pro?Asp?His?Asn?Lys?Gly?Ile?Ala?Ser?Asn?Phe?Leu?Ser?Met?Val?Phe

150 155 160 165

ggc?aat?gat?gat?ggt?tct?gta?gcc?aac?tcc?gca?gat?gac?atc?cgc?gat 643

Gly?Asn?Asp?Asp?Gly?Ser?Val?Ala?Asn?Ser?Ala?Asp?Asp?Ile?Arg?Asp

170 175 180

ttt?gaa?cgc?tcc?ctc?atc?ctc?tac?gcc?gag?cac?tcc?ttc?aac?gcc?tcc 691

Phe?Glu?Arg?Ser?Leu?Ile?Leu?Tyr?Ala?Glu?His?Ser?Phe?Asn?Ala?Ser

185 190 195

aca?ttc?tca?gcc?cgc?gtg?atc?tca?tca?acg?cga?tcc?gat?acg?tat?tcg 739

Thr?Phe?Ser?Ala?Arg?Val?Ile?Ser?Ser?Thr?Arg?Ser?Asp?Thr?Tyr?Ser

200 205 210

gcg?atc?aca?ggt?gcg?atc?ggt?gct?ctc?aaa?ggc?cca?ctg?cac?gga?ggt 787

Ala?Ile?Thr?Gly?Ala?Ile?Gly?Ala?Leu?Lys?Gly?Pro?Leu?His?Gly?Gly

215 220 225

gcc?aat?gag?ttt?gtc?atg?cac?acc?atg?ctg?gat?atc?gac?gat?ccc?aac 835

Ala?Asn?Glu?Phe?Val?Met?His?Thr?Met?Leu?Asp?Ile?Asp?Asp?Pro?Asn

230 235 240 245

aat?gct?gcc?gac?tgg?atg?ggc?aag?gcg?ttg?gat?cgt?aaa?gaa?cgc?atc 883

Asn?Ala?Ala?Asp?Trp?Met?Gly?Lys?Ala?Leu?Asp?Arg?Lys?Glu?Arg?Ile

250 255 260

atg?gga?ttc?ggg?cac?cgc?gtg?tac?aaa?aac?ggc?gac?tcc?agg?gtc?ccc 931

Met?Gly?Phe?Gly?His?Arg?Val?Tyr?Lys?Asn?Gly?Asp?Ser?Arg?Val?Pro

265 270 275

tcc?atg?gag?aaa?tcc?atg?cgc?tcc?ctt?gct?gct?cgt?cac?cgt?ggt?caa 979

Ser?Met?Glu?Lys?Ser?Met?Arg?Ser?Leu?Ala?Ala?Arg?His?Arg?Gly?Gln

280 285 290

aaa?tgg?gtg?cac?atg?tat?gag?tcg?atg?caa?gaa?gtc?atg?gag?gct?cgc 1027

Lys?Trp?Val?His?Met?Tyr?Glu?Ser?Met?Gln?Glu?Val?Met?Glu?Ala?Arg

295 300 305

act?ggc?att?aaa?ccc?aac?ctc?gac?ttc?ccg?gcc?ggc?cct?gcc?tat?tac 1075

Thr?Gly?Ile?Lys?Pro?Asn?Leu?Asp?Phe?Pro?Ala?Gly?Pro?Ala?Tyr?Tyr

310 315 320 325

atg?ctg?gga?ttc?ccc?gtc?gac?ttc?ttc?aca?cca?ctg?ttt?gtg?ctg?gcc 1123

Met?Leu?Gly?Phe?Pro?Val?Asp?Phe?Phe?Thr?Pro?Leu?Phe?Val?Leu?Ala

330 335 340

cga?gtg?tca?ggg?tgg?acg?gca?cac?atc?gtg?gag?caa?ttt?gaa?aac?aat 1171

Arg?Val?Ser?Gly?Trp?Thr?Ala?His?Ile?Val?Glu?Gln?Phe?Glu?Asn?Asn

345 350 355

gcg?ctg?atc?cga?cca?ttg?tct?gcc?tac?aac?gga?gtg?gaa?gaa?agg?gag 1219

Ala?Leu?Ile?Arg?Pro?Leu?Ser?Ala?Tyr?Asn?Gly?Val?Glu?Glu?Arg?Glu

360 365 370

gtg?gtg?ccc?att?tcg?gag?aga?acc?taatcagtga?ggctgatttc?taa 1266

Val?Val?Pro?Ile?Ser?Glu?Arg?Thr

375 380

<210>620

<211>381

<212>PRT

＜213〉Corynebacterium glutamicum

<400>620

Met?Ser?Asp?Ser?Gln?Val?Arg?Lys?Gly?Leu?Asn?Gly?Val?Ile?Ser?Asp

1 5 10 15

Tyr?Thr?Ser?Ile?Ser?Lys?Val?Met?Pro?Glu?Ser?Asn?Ser?Leu?Thr?Tyr

20 25 30

Arg?Gly?Tyr?Ala?Val?Glu?Asp?Leu?Val?Glu?Asn?Cys?Ser?Phe?Glu?Glu

35 40 45

Val?Ile?Tyr?Leu?Leu?Trp?Phe?Gly?Glu?Leu?Pro?Thr?Thr?Glu?Gln?Leu

50 55 60

Arg?Thr?Phe?Asn?Thr?Thr?Gly?Arg?Ser?Tyr?Arg?Ser?Leu?Asp?Ala?Gly

65 70 75 80

Leu?Ile?Ser?Leu?Ile?His?Ser?Leu?Pro?Asn?Thr?Cys?His?Pro?Met?Asp

85 90 95

Val?Leu?Arg?Thr?Ala?Val?Ser?Tyr?Met?Gly?Thr?Phe?Asp?Pro?Asp?Pro

100 105 110

Phe?Thr?Arg?Asp?Ala?Asp?His?Ile?Arg?Ser?Ile?Gly?His?Asn?Leu?Leu

115 120 125

Ala?Gln?Leu?Pro?Met?Val?Val?Ala?Met?Asp?Ile?Arg?Arg?Arg?Ser?Gly

130 135 140

Glu?Glu?Ile?Ile?Ala?Pro?Asp?His?Asn?Lys?Gly?Ile?Ala?Ser?Asn?Phe

145 150 155 160

Leu?Ser?Met?Val?Phe?Gly?Asn?Asp?Asp?Gly?Ser?Val?Ala?Asn?Ser?Ala

165 170 175

Asp?Asp?Ile?Arg?Asp?Phe?Glu?Arg?Ser?Leu?Ile?Leu?Tyr?Ala?Glu?His

180 185 190

Ser?Phe?Asn?Ala?Ser?Thr?Phe?Ser?Ala?Arg?Val?Ile?Ser?Ser?Thr?Arg

195 200 205

Ser?Asp?Thr?Tyr?Ser?Ala?Ile?Thr?Gly?Ala?Ile?Gly?Ala?Leu?Lys?Gly

210 215 220

Pro?Leu?His?Gly?Gly?Ala?Asn?Glu?Phe?Val?Met?His?Thr?Met?Leu?Asp

225 230 235 240

Ile?Asp?Asp?Pro?Asn?Asn?Ala?Ala?Asp?Trp?Met?Gly?Lys?Ala?Leu?Asp

245 250 255

Arg?Lys?Glu?Arg?Ile?Met?Gly?Phe?Gly?His?Arg?Val?Tyr?Lys?Asn?Gly

260 265 270

Asp?Ser?Arg?Val?Pro?Ser?Met?Glu?Lys?Ser?Met?Arg?Ser?Leu?Ala?Ala

275 280 285

Arg?His?Arg?Gly?Gln?Lys?Trp?Val?His?Met?Tyr?Glu?Ser?Met?Gln?Glu

290 295 300

Val?Met?Glu?Ala?Arg?Thr?Gly?Ile?Lys?Pro?Asn?Leu?Asp?Phe?Pro?Ala

305 310 315 320

Gly?Pro?Ala?Tyr?Tyr?Met?Leu?Gly?Phe?Pro?Val?Asp?Phe?Phe?Thr?Pro

325 330 335

Leu?Phe?Val?Leu?Ala?Arg?Val?Ser?Gly?Trp?Thr?Ala?His?Ile?Val?Glu

340 345 350

Gln?Phe?Glu?Asn?Asn?Ala?Leu?Ile?Arg?Pro?Leu?Ser?Ala?Tyr?Asn?Gly

355 360 365

Val?Glu?Glu?Arg?Glu?Val?Val?Pro?Ile?Ser?Glu?Arg?Thr

370 375 380

<210>621

<211>1038

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1015)

<223>RXN02333

<400>621

tcttgcatgc?cgtgcaaagc?ctgcctgacc?tggatgatct?tgatcagctc?aacatcgaag?60

tcgacataag?caaccaggcc?gcgacgaaag?cggggctgtt?atg?aat?ctc?ttt?tcg 115

Met?Asn?Leu?Phe?Ser

1 5

aat?ggt?gtt?gat?gtg?ggg?agg?cgt?cga?caa?gca?ttt?aaa?gcg?gca?ctc 163

Asn?Gly?Val?Asp?Val?Gly?Arg?Arg?Arg?Gln?Ala?Phe?Lys?Ala?Ala?Leu

10 15 20

gcc?gca?ccc?cac?atc?gcc?cgg?ctg?ccc?ggc?gca?ttc?tcc?cct?ctg?att 211

Ala?Ala?Pro?His?Ile?Ala?Arg?Leu?Pro?Gly?Ala?Phe?Ser?Pro?Leu?Ile

25 30 35

gcg?cgc?tcc?atc?gaa?gaa?gcc?ggc?ttc?gaa?ggc?gtc?tac?gtt?tcc?ggc 259

Ala?Arg?Ser?Ile?Glu?Glu?Ala?Gly?Phe?Glu?Gly?Val?Tyr?Val?Ser?Gly

40 45 50

gcc?gtc?ata?gct?gct?gac?ctg?gca?cta?ccc?gat?atc?ggc?ttg?acg?acg 307

Ala?Val?Ile?Ala?Ala?Asp?Leu?Ala?Leu?Pro?Asp?Ile?Gly?Leu?Thr?Thr

55 60 65

ctg?acc?gaa?gtc?gcc?cac?cgc?gcg?cgg?caa?att?gcg?cgc?gtc?aca?gac 355

Leu?Thr?Glu?Val?Ala?His?Arg?Ala?Arg?Gln?Ile?Ala?Arg?Val?Thr?Asp

70 75 80 85

cta?gga?gtg?ctt?gtc?gac?gcc?gac?acc?ggc?ttt?ggc?gaa?ccc?atg?tcg 403

Leu?Gly?Val?Leu?Val?Asp?Ala?Asp?Thr?Gly?Phe?Gly?Glu?Pro?Met?Ser

90 95 100

gcc?gca?cgc?acc?gtc?gcc?gaa?ttg?gag?gac?gcc?ggt?gtg?gcc?gga?tgc 451

Ala?Ala?Arg?Thr?Val?Ala?Glu?Leu?Glu?Asp?Ala?Gly?Val?Ala?Gly?Cys

105 110 115

cac?ctt?gaa?gac?caa?gtc?aac?ccc?aaa?cgt?tgc?ggg?cac?ttg?gac?ggc 499

His?Leu?Glu?Asp?Gln?Val?Asn?Pro?Lys?Arg?Cys?Gly?His?Leu?Asp?Gly

120 125 130

aaa?gaa?gtc?gtg?cgc?aca?gac?gtg?atg?gtt?cga?cgc?atc?gca?gcc?gcc 547

Lys?Glu?Val?Val?Arg?Thr?Asp?Val?Met?Val?Arg?Arg?Ile?Ala?Ala?Ala

135 140 145

gtc?tcg?gcc?cgg?cgc?gac?ccg?aac?ttt?gtc?atc?tgc?gcc?cgc?acc?gac 595

Val?Ser?Ala?Arg?Arg?Asp?Pro?Asn?Phe?Val?Ile?Cys?Ala?Arg?Thr?Asp

150 155 160 165

gcc?gct?gga?gtg?gaa?gga?atc?gac?gcc?gcc?att?gag?cgc?gcg?aaa?gcc 643

Ala?Ala?Gly?Val?Glu?Gly?Ile?Asp?Ala?Ala?Ile?Glu?Arg?Ala?Lys?Ala

170 175 180

tac?tta?gat?gcg?ggc?gcc?gac?atg?att?ttc?acc?gaa?gcc?ctc?cac?agc 691

Tyr?Leu?Asp?Ala?Gly?Ala?Asp?Met?Ile?Phe?Thr?Glu?Ala?Leu?His?Ser

185 190 195

gaa?gcc?gac?ttc?cga?tac?ttc?cgg?cac?gcc?atc?cct?gat?gcc?ttg?ttg 739

Glu?Ala?Asp?Phe?Arg?Tyr?Phe?Arg?His?Ala?Ile?Pro?Asp?Ala?Leu?Leu

200 205 210

ctg?gcg?aat?atg?acc?gaa?ttt?ggc?aaa?acg?acg?ctg?ctg?tca?gcc?gac 787

Leu?Ala?Asn?Met?Thr?Glu?Phe?Gly?Lys?Thr?Thr?Leu?Leu?Ser?Ala?Asp

215 220 225

gtg?ttg?gaa?gag?att?ggc?tac?aac?gcc?gtg?atc?tac?ccc?gtg?acc?acg 835

Val?Leu?Glu?Glu?Ile?Gly?Tyr?Asn?Ala?Val?Ile?Tyr?Pro?Val?Thr?Thr

230 235 240 245

ctg?cgt?att?gcc?atg?gga?caa?gta?gaa?caa?gca?cta?gcc?gaa?atc?aaa 883

Leu?Arg?Ile?Ala?Met?Gly?Gln?Val?Glu?Gln?Ala?Leu?Ala?Glu?Ile?Lys

250 255 260

gaa?cac?ggt?acc?caa?gaa?gga?tgg?ctg?gac?cgc?atg?caa?cac?cgc?agc 931

Glu?His?Gly?Thr?Gln?Glu?Gly?Trp?Leu?Asp?Arg?Met?Gln?His?Arg?Ser

265 270 275

aga?tta?tat?gag?ctc?ctg?cga?tac?gaa?gac?tac?aac?gtc?ttt?gac?cag 979

Arg?Leu?Tyr?Glu?Leu?Leu?Arg?Tyr?Glu?Asp?Tyr?Asn?Val?Phe?Asp?Gln

280 285 290

cac?att?ttc?acc?tac?aga?aaa?gga?gaa?aac?aat?gag?tgacagccaa 1025

His?Ile?Phe?Thr?Tyr?Arg?Lys?Gly?Glu?Asn?Asn?Glu

295 300 305

gtccgcaaag?gac 1038

<210>622

<211>305

<212>PRT

＜213〉Corynebacterium glutamicum

<400>622

Met?Asn?Leu?Phe?Ser?Asn?Gly?Val?Asp?Val?Gly?Arg?Arg?Arg?Gln?Ala

1 5 10 15

Phe?Lys?Ala?Ala?Leu?Ala?Ala?Pro?His?Ile?Ala?Arg?Leu?Pro?Gly?Ala

20 25 30

Phe?Ser?Pro?Leu?Ile?Ala?Arg?Ser?Ile?Glu?Glu?Ala?Gly?Phe?Glu?Gly

35 40 45

Val?Tyr?Val?Ser?Gly?Ala?Val?Ile?Ala?Ala?Asp?Leu?Ala?Leu?Pro?Asp

50 55 60

Ile?Gly?Leu?Thr?Thr?Leu?Thr?Glu?Val?Ala?His?Arg?Ala?Arg?Gln?Ile

65 70 75 80

Ala?Arg?Val?Thr?Asp?Leu?Gly?Val?Leu?Val?Asp?Ala?Asp?Thr?Gly?Phe

85 90 95

Gly?Glu?Pro?Met?Ser?Ala?Ala?Arg?Thr?Val?Ala?Glu?Leu?Glu?Asp?Ala

l00 105 110

Gly?Val?Ala?Gly?Cys?His?Leu?Glu?Asp?Gln?Val?Asn?Pro?Lys?Arg?Cys

115 120 125

Gly?His?Leu?Asp?Gly?Lys?Glu?Val?Val?Arg?Thr?Asp?Val?Met?Val?Arg

130 135 140

Arg?Ile?Ala?Ala?Ala?Val?Ser?Ala?Arg?Arg?Asp?Pro?Asn?Phe?Val?Ile

145 150 155 160

Cys?Ala?Arg?Thr?Asp?Ala?Ala?Gly?Val?Glu?Gly?Ile?Asp?Ala?Ala?Ile

165 170 175

Glu?Arg?Ala?Lys?Ala?Tyr?Leu?Asp?Ala?Gly?Ala?Asp?Met?Ile?Phe?Thr

180 185 190

Glu?Ala?Leu?His?Ser?Glu?Ala?Asp?Phe?Arg?Tyr?Phe?Arg?His?Ala?Ile

195 200 205

Pro?Asp?Ala?Leu?Leu?Leu?Ala?Asn?Met?Thr?Glu?Phe?Gly?Lys?Thr?Thr

210 215 220

Leu?Leu?Ser?Ala?Asp?Val?Leu?Glu?Glu?Ile?Gly?Tyr?Asn?Ala?Val?Ile

225 230 235 240

Tyr?Pro?Val?Thr?Thr?Leu?Arg?Ile?Ala?Met?Gly?Gln?Val?Glu?Gln?Ala

245 250 255

Leu?Ala?Glu?Ile?Lys?Glu?His?Gly?Thr?Gln?Glu?Gly?Trp?Leu?Asp?Arg

260 265 270

Met?Gln?His?Arg?Ser?Arg?Leu?Tyr?Glu?Leu?Leu?Arg?Tyr?Glu?Asp?Tyr

275 280 285

Asn?Val?Phe?Asp?Gln?His?Ile?Phe?Thr?Tyr?Arg?Lys?Gly?Glu?Asn?Asn

290 295 300

Glu

305

<210>623

<211>242

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(219)

<223>FRXA02333

<400>623

gag?att?ggc?tac?aac?gcc?gtg?atc?tac?ccc?gtg?acc?acg?ctg?cgt?att 48

Glu?Ile?Gly?Tyr?Asn?Ala?Val?Ile?Tyr?Pro?Val?Thr?Thr?Leu?Arg?Ile

1 5 10 15

gcc?atg?gga?caa?gta?gaa?caa?gca?cta?gcc?gaa?atc?aaa?gaa?cac?ggt 96

Ala?Met?Gly?Gln?Val?Glu?Gln?Ala?Leu?Ala?Glu?Ile?Lys?Glu?His?Gly

20 25 30

acc?caa?gaa?gga?tgg?ctg?gac?cgc?atg?caa?cac?cgc?agc?aga?tta?tat 144

Thr?Gln?Glu?Gly?Trp?Leu?Asp?Arg?Met?Gln?His?Arg?Ser?Arg?Leu?Tyr

35 40 45

gag?ctc?ctg?cga?tac?gaa?gac?tac?aac?gtc?ttt?gac?cag?cac?att?ttc 192

Glu?Leu?Leu?Arg?Tyr?Glu?Asp?Tyr?Asn?Val?Phe?Asp?Gln?His?Ile?Phe

50 55 60

acc?tac?aga?aaa?gga?gaa?aac?aat?gag?tgacagccaa?gtccgcaaag 239

Thr?Tyr?Arg?Lys?Gly?Glu?Asn?Asn?Glu

65 70

gac 242

<210>624

<211>73

<212>PRT

＜213〉Corynebacterium glutamicum

<400>?624

Glu?Ile?Gly?Tyr?Asn?Ala?Val?Ile?Tyr?Pro?Val?Thr?Thr?Leu?Arg?Ile

1 5 10 15

Ala?Met?Gly?Gln?Val?Glu?Gln?Ala?Leu?Ala?Glu?Ile?Lys?Glu?His?Gly

20 25 30

Thr?Gln?Glu?Gly?Trp?Leu?Asp?Arg?Met?Gln?His?Arg?Ser?Arg?Leu?Tyr

35 40 45

Glu?Leu?Leu?Arg?Tyr?Glu?Asp?Tyr?Asn?Val?Phe?Asp?Gln?His?Ile?Phe

50 55 60

Thr?Tyr?Arg?Lys?Gly?Glu?Asn?Asn?Glu

65 70

<210>625

<211>513

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(490)

<223>RXA00030

<400>625

taaaaacgcc?actttggtgt?cgataacacc?gaacttccga?acataaaaga?tgcgttggtg?60

ctctctgcac?aatgtttctt?tcggaactat?tctggcgacc?atg?cga?att?gaa?atc 115

Met?Arg?Ile?Glu?Ile

1 5

aca?agc?gta?ttt?gtt?gat?gac?cag?gcc?aaa?gca?ctc?gat?ttc?tac?acc 163

Thr?Ser?Val?Phe?Val?Asp?Asp?Gln?Ala?Lys?Ala?Leu?Asp?Phe?Tyr?Thr

10 15 20

acg?aag?ctc?gga?ttt?gag?ctc?aaa?cac?gat?gta?act?gct?ggt?gac?tac 211

Thr?Lys?Leu?Gly?Phe?Glu?Leu?Lys?His?Asp?Val?Thr?Ala?Gly?Asp?Tyr

25 30 35

cgc?tgg?ttg?act?gtt?gtt?gat?cca?gaa?aac?cca?gat?ggt?gtg?cag?ctt 259

Arg?Trp?Leu?Thr?Val?Val?Asp?Pro?Glu?Asn?Pro?Asp?Gly?Val?Gln?Leu

40 45 50

ttg?ttg?gaa?cca?aac?cag?cac?cca?gat?gca?gcg?act?tac?caa?gct?gga 307

Leu?Leu?Glu?Pro?Asn?Gln?His?Pro?Asp?Ala?Ala?Thr?Tyr?Gln?Ala?Gly

55 60 65

att?aaa?cga?gac?ggt?att?ccc?gct?aca?cag?ttt?tat?gtt?gat?gat?gtg 355

Ile?Lys?Arg?Asp?Gly?Ile?Pro?Ala?Thr?Gln?Phe?Tyr?Val?Asp?Asp?Val

70 75 80 85

cag?gaa?gaa?tat?gac?agc?ctc?aag?gat?aaa?ggc?gtg?gat?ttc?atc?atg 403

Gln?Glu?Glu?Tyr?Asp?Ser?Leu?Lys?Asp?Lys?Gly?Val?Asp?Phe?Ile?Met

90 95 100

gaa?cca?acc?gat?gtg?ggc?cct?tca?gtg?att?gcc?att?ctc?gat?gac?acc 451

Glu?Pro?Thr?Asp?Val?Gly?Pro?Ser?Val?Ile?Ala?Ile?Leu?Asp?Asp?Thr

105 ll0 115

gta?gga?aac?cta?att?cag?att?gtt?caa?ttg?aag?cag?aac?taaccccgtg 500

Val?Gly?Asn?Leu?Ile?Gln?Ile?Val?Gln?Leu?Lys?Gln?Asn

120 125 130

gaatgacaaa?atc 513

<210>626

<211>130

<212>PRT

＜213〉Corynebacterium glutamicum

<400>626

Met?Arg?Ile?Glu?Ile?Thr?Ser?Val?Phe?Val?Asp?Asp?Gln?Ala?Lys?Ala

1 5 10 15

Leu?Asp?Phe?Tyr?Thr?Thr?Lys?Leu?Gly?Phe?Glu?Leu?Lys?His?Asp?Val

20 25 30

Thr?Ala?Gly?Asp?Tyr?Arg?Trp?Leu?Thr?Val?Val?Asp?Pro?Glu?Asn?Pro

35 40 45

Asp?Gly?Val?Gln?Leu?Leu?Leu?Glu?Pro?Asn?Gln?His?Pro?Asp?Ala?Ala

50 55 60

Thr?Tyr?Gln?Ala?Gly?Ile?Lys?Arg?Asp?Gly?Ile?Pro?Ala?Thr?Gln?Phe

65 70 75 80

Tyr?Val?Asp?Asp?Val?Gln?Glu?Glu?Tyr?Asp?Ser?Leu?Lys?Asp?Lys?Gly

85 90 95

Val?Asp?Phe?Ile?Met?Glu?Pro?Thr?Asp?Val?Gly?Pro?Ser?Val?Ile?Ala

100 105 110

Ile?Leu?Asp?Asp?Thr?Val?Gly?Asn?Leu?Ile?Gln?Ile?Val?Gln?Leu?Lys

115 120 125

Gln?Asn

130

<210>627

<211>2334

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(2311)

<223>RXN00148

<400>627

ctttgagggc?agcgcgcatg?cgcccgatgg?ttatttgaac?atgacaattg?atgccgcggc?60

gacgctggct?gacctgctag?atgctttggg?agcttaaatc?atg?acg?tcg?atc?cct 115

Met?Thr?Ser?Ile?Pro

1 5

aat?ttt?tca?gac?atc?cca?ttg?act?gct?gag?aca?cgt?gca?tcg?gag?tca 163

Asn?Phe?Ser?Asp?Ile?Pro?Leu?Thr?Ala?Glu?Thr?Arg?Ala?Ser?Glu?Ser

10 15 20

cac?aac?gtt?gac?gcc?ggc?aag?gtg?tgg?aac?act?ccc?gaa?ggc?att?gat 211

His?Asn?Val?Asp?Ala?Gly?Lys?Val?Trp?Asn?Thr?Pro?Glu?Gly?Ile?Asp

25 30 35

gtc?aag?cgc?gta?ttc?acg?cag?gct?gac?cgc?gac?gag?gcg?caa?gcg?gcg 259

Val?Lys?Arg?Val?Phe?Thr?Gln?Ala?Asp?Arg?Asp?Glu?Ala?Gln?Ala?Ala

40 45 50

gga?cat?ccg?gtg?gat?tct?ttg?cca?ggt?caa?aag?cca?ttt?atg?cgc?ggg 307

Gly?His?Pro?Val?Asp?Ser?Leu?Pro?Gly?Gln?Lys?Pro?Phe?Met?Arg?Gly

55 60 65

ccg?tac?cca?act?atg?tac?acc?aat?cag?ccg?tgg?acg?att?cgc?cag?tac 355

Pro?Tyr?Pro?Thr?Met?Tyr?Thr?Asn?Gln?Pro?Trp?Thr?Ile?Arg?Gln?Tyr

70 75 80 85

gca?ggc?ttt?tca?acc?gcc?gcg?gaa?tcc?aat?gcg?ttt?tat?cgg?agg?aac 403

Ala?Gly?Phe?Ser?Thr?Ala?Ala?Glu?Ser?Asn?Ala?Phe?Tyr?Arg?Arg?Asn

90 95 100

ctt?gct?gcg?ggt?caa?aaa?ggt?ttg?tcg?gtt?gcg?ttc?gat?cta?gcg?acc 451

Leu?Ala?Ala?Gly?Gln?Lys?Gly?Leu?Ser?Val?Ala?Phe?Asp?Leu?Ala?Thr

105 110 115

cac?cgc?ggt?tat?gac?tcg?gat?aat?gag?cgc?gtg?gtc?ggc?gat?gtg?ggt 499

His?Arg?Gly?Tyr?Asp?Ser?Asp?Asn?Glu?Arg?Val?Val?Gly?Asp?Val?Gly

120 125 130

atg?gcc?ggc?gtg?gcg?att?gat?tcg?att?ttg?gat?atg?cgt?cag?ctg?ttt 547

Met?Ala?Gly?Val?Ala?Ile?Asp?Ser?Ile?Leu?Asp?Met?Arg?Gln?Leu?Phe

135 140 145

gat?ggc?att?gat?ttg?tcc?agc?gtg?tcg?gtg?tcg?atg?acc?atg?aat?ggc 595

Asp?Gly?Ile?Asp?Leu?Ser?Ser?Val?Ser?Val?Ser?Met?Thr?Met?Asn?Gly

150 155 160 165

gct?gtg?ctg?ccg?att?ctt?gcg?ttc?tat?atc?gtg?gcg?gct?gag?gaa?caa 643

Ala?Val?Leu?Pro?Ile?Leu?Ala?Phe?Tyr?Ile?Val?Ala?Ala?Glu?Glu?Gln

170 175 180

ggt?gtg?ggt?ccg?gag?cag?ctt?gcg?ggc?acg?atc?cag?aat?gac?atc?ttg 691

Gly?Val?Gly?Pro?Glu?Gln?Leu?Ala?Gly?Thr?Ile?Gln?Asn?Asp?Ile?Leu

185 190 195

aaa?gaa?ttt?atg?gtg?cgc?aac?acc?tat?att?tat?ccg?ccg?aag?ccg?tcg 739

Lys?Glu?Phe?Met?Val?Arg?Asn?Thr?Tyr?Ile?Tyr?Pro?Pro?Lys?Pro?Ser

200 205 210

atg?cgc?atc?att?tcc?aac?atc?ttt?gag?tac?acc?tcc?ttg?aag?atg?cca 787

Met?Arg?Ile?Ile?Ser?Asn?Ile?Phe?Glu?Tyr?Thr?Ser?Leu?Lys?Met?Pro

215 220 225

cgt?ttt?aac?tcc?att?tcg?att?tct?ggc?tat?cac?atc?cag?gaa?gcg?gga 835

Arg?Phe?Asn?Ser?Ile?Ser?Ile?Ser?Gly?Tyr?His?Ile?Gln?Glu?Ala?Gly

230 235 240 245

gcg?act?gcc?gat?ttg?gag?ctg?gcc?tac?act?ctg?gcg?gat?ggt?att?gaa 883

Ala?Thr?Ala?Asp?Leu?Glu?Leu?Ala?Tyr?Thr?Leu?Ala?Asp?Gly?Ile?Glu

250 255 260

tac?atc?cgt?gca?ggt?aaa?gag?gta?ggc?ctt?gac?gtg?gat?aag?ttc?gcg 931

Tyr?Ile?Arg?Ala?Gly?Lys?Glu?Val?Gly?Leu?Asp?Val?Asp?Lys?Phe?Ala

265 270 275

cct?cgt?ctg?tcc?ttc?ttc?tgg?ggt?att?tct?atg?tac?acc?ttc?atg?gag 979

Pro?Arg?Leu?Ser?Phe?Phe?Trp?Gly?Ile?Ser?Met?Tyr?Thr?Phe?Met?Glu

280 285 290

atc?gca?aag?ctg?cgt?gcg?gga?cga?ctg?ctg?tgg?agc?gag?ttg?gtg?gca 1027

Ile?Ala?Lys?Leu?Arg?Ala?Gly?Arg?Leu?Leu?Trp?Ser?Glu?Leu?Val?Ala

295 300 305

aaa?ttc?gat?ccg?aaa?aac?gcc?aag?tcc?cag?tcg?ctg?cgc?acg?cac?tcg 1075

Lys?Phe?Asp?Pro?Lys?Asn?Ala?Lys?Ser?Gln?Ser?Leu?Arg?Thr?His?Ser

310 315 320 325

cag?acc?tct?ggt?tgg?tcg?ttg?acc?gcg?cag?gat?gtg?tac?aac?aac?gtc 1123

Gln?Thr?Ser?Gly?Trp?Ser?Leu?Thr?Ala?Gln?Asp?Val?Tyr?Asn?Asn?Val

330 335 340

gcc?cgc?acc?gcg?att?gag?gcg?atg?gct?gca?acc?cag?ggc?cac?acc?cag 1171

Ala?Arg?Thr?Ala?Ile?Glu?Ala?Met?Ala?Ala?Thr?Gln?Gly?His?Thr?Gln

345 350 355

tcg?ctg?cac?acc?aat?gca?ctt?gat?gag?gcg?ttg?gcg?ctg?ccc?acc?gat 1219

Ser?Leu?His?Thr?Asn?Ala?Leu?Asp?Glu?Ala?Leu?Ala?Leu?Pro?Thr?Asp

360 365 370

ttc?tct?gct?cgt?atc?gcc?cga?aac?acc?cag?ctg?ttg?ctg?cag?cag?gaa 1267

Phe?Ser?Ala?Arg?Ile?Ala?Arg?Asn?Thr?Gln?Leu?Leu?Leu?Gln?Gln?Glu

375 380 385

tct?ggc?acg?gtg?cgt?cca?gtt?gat?cca?tgg?gcg?ggc?tcc?tat?tac?gtg 1315

Ser?Gly?Thr?Val?Arg?Pro?Val?Asp?Pro?Trp?Ala?Gly?Ser?Tyr?Tyr?Val

390 395 400 405

gag?tgg?ttg?acc?aat?gag?ctg?gct?aac?cgc?gcg?cgc?aag?cac?atc?gat 1363

Glu?Trp?Leu?Thr?Asn?Glu?Leu?Ala?Asn?Arg?Ala?Arg?Lys?His?Ile?Asp

410 415 420

gag?gtg?gag?gaa?gcc?ggc?gga?atg?gcg?cag?gcc?acc?gcg?cag?gga?att 1411

Glu?Val?Glu?Glu?Ala?Gly?Gly?Met?Ala?Gln?Ala?Thr?Ala?Gln?Gly?Ile

425 430 435

cct?aag?ctg?cgc?att?gag?gaa?tca?gcg?gca?cgc?acc?cag?gct?cgc?att 1459

Pro?Lys?Leu?Arg?Ile?Glu?Glu?Ser?Ala?Ala?Arg?Thr?Gln?Ala?Arg?Ile

440 445 450

gat?tcc?ggc?cgc?cag?gcg?ctg?atc?ggc?gtg?aat?cgc?tac?gtg?gcg?gaa 1507

Asp?Ser?Gly?Arg?Gln?Ala?Leu?Ile?Gly?Val?Asn?Arg?Tyr?Val?Ala?Glu

455 460 465

gaa?gat?gag?gaa?att?gaa?gtc?ctc?aag?gtt?gac?aac?acc?aag?gtt?cgc 1555

Glu?Asp?Glu?Glu?Ile?Glu?Val?Leu?Lys?Val?Asp?Asn?Thr?Lys?Val?Arg

470 475 480 485

gca?gaa?cag?ttg?gct?aaa?ctc?gcg?caa?ctg?aaa?gca?gag?cgc?aac?gat 1603

Ala?Glu?Gln?Leu?Ala?Lys?Leu?Ala?Gln?Leu?Lys?Ala?Glu?Arg?Asn?Asp

490 495 500

gcg?gaa?gtc?aag?gct?gcg?ctg?gat?gcg?ttg?aca?gct?gct?gcc?cgc?aac 1651

Ala?Glu?Val?Lys?Ala?Ala?Leu?Asp?Ala?Leu?Thr?Ala?Ala?Ala?Arg?Asn

505 510 515

gag?cat?aaa?gag?cca?ggg?gat?ttg?gat?cag?aac?ctg?ctc?aaa?ctt?gcc 1699

Glu?His?Lys?Glu?Pro?Gly?Asp?Leu?Asp?Gln?Asn?Leu?Leu?Lys?Leu?Ala

520 525 530

gtc?gat?gct?gcg?cgc?gca?aaa?gct?acc?att?gga?gag?atc?tcc?gat?gct 1747

Val?Asp?Ala?Ala?Arg?Ala?Lys?Ala?Thr?Ile?Gly?Glu?Ile?Ser?Asp?Ala

535 540 545

ttg?gaa?gtt?gtc?ttt?ggc?cgc?cac?gaa?gca?gaa?atc?agg?acg?ctg?tct 1795

Leu?Glu?Val?Val?Phe?Gly?Arg?His?Glu?Ala?Glu?Ile?Arg?Thr?Leu?Ser

550 555 560 565

ggc?gtg?tac?aag?gat?gag?gtt?gga?aag?gaa?ggc?aca?gtg?agc?aac?gtc 1843

Gly?Val?Tyr?Lys?Asp?Glu?Val?Gly?Lys?Glu?Gly?Thr?Val?Ser?Asn?Val

570 575 580

gaa?cgc?gcg?atc?gcc?ctg?gct?gac?gcc?ttt?gag?gct?gag?gaa?ggc?cgc 1891

Glu?Arg?Ala?Ile?Ala?Leu?Ala?Asp?Ala?Phe?Glu?Ala?Glu?Glu?Gly?Arg

585 590 595

cgc?cca?cgt?atc?ttt?att?gcc?aag?atg?ggc?cag?gat?gga?cat?gac?cgt 1939

Arg?Pro?Arg?Ile?Phe?Ile?Ala?Lys?Met?Gly?Gln?Asp?Gly?His?Asp?Arg

600 605 610

gga?cag?aag?gtt?gtc?gcg?tct?gcc?tat?gct?gac?ctg?ggc?atg?gac?gtg 1987

Gly?Gln?Lys?Val?Val?Ala?Ser?Ala?Tyr?Ala?Asp?Leu?Gly?Met?Asp?Val

615 620 625

gat?gtt?gga?ccg?ctg?ttt?caa?act?cca?gcc?gaa?gct?gcc?cgc?gcc?gcc 2035

Asp?Val?Gly?Pro?Leu?Phe?Gln?Thr?Pro?Ala?Glu?Ala?Ala?Arg?Ala?Ala

630 635 640 645

gtg?gac?gcc?gat?gtt?cac?gtg?gtg?ggt?atg?tct?tcg?ctg?gca?gca?ggc 2083

Val?Asp?Ala?Asp?Val?His?Val?Val?Gly?Met?Ser?Ser?Leu?Ala?Ala?Gly

650 655 660

cac?ctc?acc?ttg?ctg?ccc?gag?ctg?aag?aaa?gaa?ctt?gca?gct?ctt?ggc 2131

His?Leu?Thr?Leu?Leu?Pro?Glu?Leu?Lys?Lys?Glu?Leu?Ala?Ala?Leu?Gly

665 670 675

cgc?gat?gac?att?ctg?gtc?acc?gtg?ggc?ggc?gtc?att?ccg?ccg?ggc?gat 2179

Arg?Asp?Asp?Ile?Leu?Val?Thr?Val?Gly?Gly?Val?Ile?Pro?Pro?Gly?Asp

680 685 690

ttc?cag?gat?ctc?tac?gat?atg?ggt?gcc?gcc?gcg?att?tac?cct?tca?gga 2227

Phe?Gln?Asp?Leu?Tyr?Asp?Met?Gly?Ala?Ala?Ala?Ile?Tyr?Pro?Ser?Gly

695 700 705

acc?gtc?atc?gcg?gag?tcg?gcg?atc?gat?ctg?atc?acc?cga?ctc?gcc?gca 2275

Thr?Val?Ile?Ala?Glu?Ser?Ala?Ile?Asp?Leu?Ile?Thr?Arg?Leu?Ala?Ala

710 715 720 725

cac?ctg?ggc?ttt?gac?ctg?gat?gtg?gat?gtg?aat?gaa?tgatcacggt 2321

His?Leu?Gly?Phe?Asp?Leu?Asp?Val?Asp?Val?Asn?Glu

730 735

ttcctaga?aca 2334

<210>628

<211>737

<212>PRT

＜213〉Corynebacterium glutamicum

<400>628

Met?Thr?Ser?Ile?Pro?Asn?Phe?Ser?Asp?Ile?Pro?Leu?Thr?Ala?Glu?Thr

1 5 10 15

Arg?Ala?Ser?Glu?Ser?His?Asn?Val?Asp?Ala?Gly?Lys?Val?Trp?Asn?Thr

20 25 30

Pro?Glu?Gly?Ile?Asp?Val?Lys?Arg?Val?Phe?Thr?Gln?Ala?Asp?Arg?Asp

35 40 45

Glu?Ala?Gln?Ala?Ala?Gly?His?Pro?Val?Asp?Ser?Leu?Pro?Gly?Gln?Lys

50 55 60

Pro?Phe?Met?Arg?Gly?Pro?Tyr?Pro?Thr?Met?Tyr?Thr?Asn?Gln?Pro?Trp

65 70 75 80

Thr?Ile?Arg?Gln?Tyr?Ala?Gly?Phe?Ser?Thr?Ala?Ala?Glu?Ser?Asn?Ala

85 90 95

Phe?Tyr?Arg?Arg?Asn?Leu?Ala?Ala?Gly?Gln?Lys?Gly?Leu?Ser?Val?Ala

100 105 110

Phe?Asp?Leu?Ala?Thr?His?Arg?Gly?Tyr?Asp?Ser?Asp?Asn?Glu?Arg?Val

115 120 125

Val?Gly?Asp?ValGly?Met?Ala?Gly?Val?Ala?Ile?Asp?Ser?Ile?Leu?Asp

130 135 140

Met?Arg?Gln?Leu?Phe?Asp?Gly?Ile?Asp?Leu?Ser?Ser?Val?Ser?Val?Ser

145 150 155 160

Met?Thr?Met?Asn?Gly?Ala?Val?Leu?Pro?Ile?Leu?Ala?Phe?Tyr?Ile?Val

165 170 175

Ala?Ala?Glu?Glu?Gln?Gly?Val?Gly?Pro?Glu?Gln?Leu?Ala?Gly?Thr?Ile

180 185 190

Gln?Asn?Asp?Ile?Leu?Lys?Glu?Phe?Met?Val?Arg?Asn?Thr?Tyr?Ile?Tyr

195 200 205

Pro?Pro?Lys?Pro?Ser?Met?Arg?Ile?Ile?Ser?Asn?Ile?Phe?Glu?Tyr?Thr

210 215 220

Ser?Leu?Lys?Met?Pro?Arg?Phe?Asn?Ser?Ile?Ser?Ile?Ser?Gly?Tyr?His

225 230 235 240

Ile?Gln?Glu?Ala?Gly?Ala?Thr?Ala?Asp?Leu?Glu?Leu?Ala?Tyr?Thr?Leu

245 250 255

Ala?Asp?Gly?Ile?Glu?Tyr?Ile?Arg?Ala?Gly?Lys?Glu?Val?Gly?Leu?Asp

260 265 270

Val?Asp?Lys?Phe?Ala?Pro?Arg?Leu?Ser?Phe?Phe?Trp?Gly?Ile?Ser?Met

275 280 285

Tyr?Thr?Phe?Met?Glu?Ile?Ala?Lys?Leu?Arg?Ala?Gly?Arg?Leu?Leu?Trp

290 295 300

Ser?Glu?Leu?Val?Ala?Lys?Phe?Asp?Pro?Lys?Asn?Ala?Lys?Ser?Gln?Ser

305 310 315 320

Leu?Arg?Thr?His?Ser?Gln?Thr?Ser?Gly?Trp?Ser?Leu?Thr?Ala?Gln?Asp

325 330 335

Val?Tyr?Asn?Asn?Val?Ala?Arg?Thr?Ala?Ile?Glu?Ala?Met?Ala?Ala?Thr

340 345 350

Gln?Gly?His?Thr?Gln?Ser?Leu?His?Thr?Asn?Ala?Leu?Asp?Glu?Ala?Leu

355 360 365

Ala?Leu?Pro?Thr?Asp?Phe?Ser?Ala?Arg?Ile?Ala?Arg?Asn?Thr?Gln?Leu

370 375 380

Leu?Leu?Gln?Gln?Glu?Ser?Gly?Thr?Val?Arg?Pro?Val?Asp?Pro?Trp?Ala

385 390 395 400

Gly?Ser?Tyr?Tyr?Val?Glu?Trp?Leu?Thr?Asn?Glu?Leu?Ala?Asn?Arg?Ala

405 410 415

Arg?Lys?His?Ile?Asp?Glu?Val?Glu?Glu?Ala?Gly?Gly?Met?Ala?Gln?Ala

420 425 430

Thr?Ala?Gln?Gly?Ile?Pro?Lys?Leu?Arg?Ile?Glu?Glu?Ser?Ala?Ala?Arg

435 440 445

Thr?Gln?Ala?Arg?Ile?Asp?Ser?Gly?Arg?Gln?Ala?Leu?Ile?Gly?Val?Asn

450 455 460

Arg?Tyr?Val?Ala?Glu?Glu?Asp?Glu?Glu?Ile?Glu?Val?Leu?Lys?Val?Asp

465 470 475 480

Asn?Thr?Lys?Val?Arg?Ala?Glu?Gln?Leu?Ala?Lys?Leu?Ala?Gln?Leu?Lys

485 490 495

Ala?Glu?Arg?Asn?Asp?Ala?Glu?Val?Lys?Ala?Ala?Leu?Asp?Ala?Leu?Thr

500 505 510

Ala?Ala?Ala?Arg?Asn?Glu?His?Lys?Glu?Pro?Gly?Asp?Leu?Asp?Gln?Asn

515 520 525

Leu?Leu?Lys?Leu?Ala?Val?Asp?Ala?Ala?Arg?Ala?Lys?Ala?Thr?Ile?Gly

530 535 540

Glu?Ile?Ser?Asp?Ala?Leu?Glu?Val?Val?Phe?Gly?Arg?His?Glu?Ala?Glu

545 550 555 560

Ile?Arg?Thr?Leu?Ser?Gly?Val?Tyr?Lys?Asp?Glu?Val?Gly?Lys?Glu?Gly

565 570 575

Thr?Val?Ser?Asn?Val?Glu?Arg?Ala?Ile?Ala?Leu?Ala?Asp?Ala?Phe?Glu

580 585 590

Ala?Glu?Glu?Gly?Arg?Arg?Pro?Arg?Ile?Phe?Ile?Ala?Lys?Met?Gly?Gln

595 600 605

Asp?Gly?His?Asp?Arg?Gly?Gln?Lys?Val?Val?Ala?Ser?Ala?Tyr?Ala?Asp

610 615 620

Leu?Gly?Met?Asp?Val?Asp?Val?Gly?Pro?Leu?Phe?Gln?Thr?Pro?Ala?Glu

625 630 635 640

Ala?Ala?Arg?Ala?Ala?Val?Asp?Ala?Asp?Val?His?Val?Val?Gly?Met?Ser

645 650 655

Ser?Leu?Ala?Ala?Gly?His?Leu?Thr?Leu?Leu?Pro?Glu?Leu?Lys?Lys?Glu

660 665 670

Leu?Ala?Ala?Leu?Gly?Arg?Asp?Asp?Ile?Leu?Val?Thr?Val?Gly?Gly?Val

675 680 685

Ile?Pro?Pro?Gly?Asp?Phe?Gln?Asp?Leu?Tyr?Asp?Met?Gly?Ala?Ala?Ala

690 695 700

Ile?Tyr?Pro?Ser?Gly?Thr?Val?Ile?Ala?Glu?Ser?Ala?Ile?Asp?Leu?Ile

705 710 715 720

Thr?Arg?Leu?Ala?Ala?His?Leu?Gly?Phe?Asp?Leu?Asp?Val?Asp?Val?Asn

725 730 735

Glu

<210>629

<211>2098

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(2098)

<223>FRXA00148

<400>629

ctttgagggc?agcgcgcatg?cgcccgatgg?ttatttgaac?atgacaattg?atgccgcggc?60

gacgctggct?gacctgctag?atgctttggg?agcttaaatc?atg?acg?tcg?atc?cct 115

Met?Thr?Ser?Ile?Pro

1 5

aat?ttt?tca?gac?atc?cca?ttg?act?gct?gag?aca?cgt?gca?tcg?gag?tca 163

Asn?Phe?Ser?Asp?Ile?Pro?Leu?Thr?Ala?Glu?Thr?Arg?Ala?Ser?Glu?Ser

10 15 20

cac?aac?gtt?gac?gcc?ggc?aag?gtg?tgg?aac?act?ccc?gaa?ggc?att?gat 211

His?Asn?Val?Asp?Ala?Gly?Lys?Val?Trp?Asn?Thr?Pro?Glu?Gly?Ile?Asp

25 30 35

gtc?aag?cgc?gta?ttc?acg?cag?gct?gac?cgc?gac?gag?gcg?caa?gcg?gcg 259

Val?Lys?Arg?Val?Phe?Thr?Gln?Ala?Asp?Arg?Asp?Glu?Ala?Gln?Ala?Ala

40 45 50

gga?cat?ccg?gtg?gat?tct?ttg?cca?ggt?caa?aag?cca?ttt?atg?cgc?ggg 307

Gly?His?Pro?Val?Asp?Ser?Leu?Pro?Gly?Gln?Lys?Pro?Phe?Met?Arg?Gly

55 60 65

ccg?tac?cca?act?atg?tac?acc?aat?cag?ccg?tgg?acg?att?cgc?cag?tac 355

Pro?Tyr?Pro?Thr?Met?Tyr?Thr?Asn?Gln?Pro?Trp?Thr?Ile?Arg?Gln?Tyr

70 75 80 85

gca?ggc?ttt?tca?acc?gcc?gcg?gaa?tcc?aat?gcg?ttt?tat?cgg?agg?aac 403

Ala?Gly?Phe?Ser?Thr?Ala?Ala?Glu?Ser?Asn?Ala?Phe?Tyr?Arg?Arg?Asn

90 95 100

ctt?gct?gcg?ggt?caa?aaa?ggt?ttg?tcg?gtt?gcg?ttc?gat?cta?gcg?acc 451

Leu?Ala?Ala?Gly?Gln?Lys?Gly?Leu?Ser?Val?Ala?Phe?Asp?Leu?Ala?Thr

105 110 115

cac?cgc?ggt?tat?gac?tcg?gat?aat?gag?cgc?gtg?gtc?ggc?gat?gtg?ggt 499

His?Arg?Gly?Tyr?Asp?Ser?Asp?Asn?Glu?Arg?Val?Val?Gly?Asp?Val?Gly

120 125 130

atg?gcc?ggc?gtg?gcg?att?gat?tcg?att?ttg?gat?atg?cgt?cag?ctg?ttt 547

Met?Ala?Gly?Val?Ala?Ile?Asp?Ser?Ile?Leu?Asp?Met?Arg?Gln?Leu?Phe

135 140 145

gat?ggc?att?gat?ttg?tcc?agc?gtg?tcg?gtg?tcg?atg?acc?atg?aat?ggc 595

Asp?Gly?Ile?Asp?Leu?Ser?Ser?Val?Ser?Val?Ser?Met?Thr?Met?Asn?Gly

150 155 160 165

gct?gtg?ctg?ccg?att?ctt?gcg?ttc?tat?atc?gtg?gcg?gct?gag?gaa?caa 643

Ala?Val?Leu?Pro?Ile?Leu?Ala?Phe?Tyr?Ile?Val?Ala?Ala?Glu?Glu?Gln

170 175 180

ggt?gtg?ggt?ccg?gag?cag?ctt?gcg?ggc?acg?atc?cag?aat?gac?atc?ttg 691

Gly?Val?Gly?Pro?Glu?Gln?Leu?Ala?Gly?Thr?Ile?Gln?Asn?Asp?Ile?Leu

185 190 195

aaa?gaa?ttt?atg?gtg?cgc?aac?acc?tat?att?tat?ccg?ccg?aag?ccg?tcg 739

Lys?Glu?Phe?Met?Val?Arg?Asn?Thr?Tyr?Ile?Tyr?Pro?Pro?Lys?Pro?Ser

200 205 210

atg?cgc?atc?att?tcc?aac?atc?ttt?gag?tac?acc?tcc?ttg?aag?atg?cca 787

Met?Arg?Ile?Ile?Ser?Asn?Ile?Phe?Glu?Tyr?Thr?Ser?Leu?Lys?Met?Pro

215 220 225

cgt?ttt?aac?tcc?att?tcg?att?tct?ggc?tat?cac?atc?cag?gaa?gcg?gga 835

Arg?Phe?Asn?Ser?Ile?Ser?Ile?Ser?Gly?Tyr?His?Ile?Gln?Glu?Ala?Gly

230 235 240 245

gcg?act?gcc?gat?ttg?gag?ctg?gcc?tac?act?ctg?gcg?gat?ggt?att?gaa 883

Ala?Thr?Ala?Asp?Leu?Glu?Leu?Ala?Tyr?Thr?Leu?Ala?Asp?Gly?Ile?Glu

250 255 260

tac?atc?cgt?gca?ggt?aaa?gag?gta?ggc?ctt?gac?gtg?gat?aag?ttc?gcg 931

Tyr?Ile?Arg?Ala?Gly?Lys?Glu?Val?Gly?Leu?Asp?Val?Asp?Lys?Phe?Ala

265 270 275

cct?cgt?ctg?tcc?ttc?ttc?tgg?ggt?att?tct?atg?tac?acc?ttc?atg?gag 979

Pro?Arg?Leu?Ser?Phe?Phe?Trp?Gly?Ile?Ser?Met?Tyr?Thr?Phe?Met?Glu

280 285 290

atc?gca?aag?ctg?cgt?gcg?gga?cga?ctg?ctg?tgg?agc?gag?ttg?gtg?gca 1027

Ile?Ala?Lys?Leu?Arg?Ala?Gly?Arg?Leu?Leu?Trp?Ser?Glu?Leu?Val?Ala

295 300 305

aaa?ttc?gat?ccg?aaa?aac?gcc?aag?tcc?cag?tcg?ctg?cgc?acg?cac?tcg 1075

Lys?Phe?Asp?Pro?Lys?Asn?Ala?Lys?Ser?Gln?Ser?Leu?Arg?Thr?His?Ser

310 315 320 325

cag?acc?tct?ggt?tgg?tcg?ttg?acc?gcg?cag?gat?gtg?tac?aac?aac?gtc 1123

Gln?Thr?Ser?Gly?Trp?Ser?Leu?Thr?Ala?Gln?Asp?Val?Tyr?Asn?Asn?Val

330 335 340

gcc?cgc?acc?gcg?att?gag?gcg?atg?gct?gca?acc?cag?ggc?cac?acc?cag 1171

Ala?Arg?Thr?Ala?Ile?Glu?Ala?Met?Ala?Ala?Thr?Gln?Gly?His?Thr?Gln

345 350 355

tcg?ctg?cac?acc?aat?gca?ctt?gat?gag?gcg?ttg?gcg?ctg?ccc?acc?gat 1219

Ser?Leu?His?Thr?Asn?Ala?Leu?Asp?Glu?Ala?Leu?Ala?Leu?Pro?Thr?Asp

360 365 370

ttc?tct?gct?cgt?atc?gcc?cga?aac?acc?cag?ctg?ttg?ctg?cag?cag?gaa 1267

Phe?Ser?Ala?Arg?Ile?Ala?Arg?Asn?Thr?Gln?Leu?Leu?Leu?Gln?Gln?Glu

375 380 385

tct?ggc?acg?gtg?cgt?cca?gtt?gat?cca?tgg?gcg?ggc?tcc?tat?tac?gtg 1315

Ser?Gly?Thr?Val?Arg?Pro?Val?Asp?Pro?Trp?Ala?Gly?Ser?Tyr?Tyr?Val

39 395 400 405

gag?tgg?ttg?acc?aat?gag?ctg?gct?aac?cgc?gcg?cgc?aag?cac?atc?gat 1363

Glu?Trp?Leu?Thr?Asn?Glu?Leu?Ala?Asn?Arg?Ala?Arg?Lys?His?Ile?Asp

410 415 420

gag?gtg?gag?gaa?gcc?ggc?gga?atg?gcg?cag?gcc?acc?gcg?cag?gga?att 1411

Glu?Val?Glu?Glu?Ala?Gly?Gly?Met?Ala?Gln?Ala?Thr?Ala?Gln?Gly?Ile

425 430 435

cct?aag?ctg?cgc?att?gag?gaa?tca?gcg?gca?cgc?acc?cag?gct?cgc?att 1459

Pro?Lys?Leu?Arg?Ile?Glu?Glu?Ser?Ala?Ala?Arg?Thr?Gln?Ala?Arg?Ile

440 445 450

gat?tcc?ggc?cgc?cag?gcg?ctg?atc?ggc?gtg?aat?cgc?tac?gtg?gcg?gaa 1507

Asp?Ser?Gly?Arg?Gln?Ala?Leu?Ile?Gly?Val?Asn?Arg?Tyr?Val?Ala?Glu

455 460 465

gaa?gat?gag?gaa?att?gaa?gtc?ctc?aag?gtt?gac?aac?acc?aag?gtt?cgc 1555

Glu?Asp?Glu?Glu?Ile?Glu?Val?Leu?Lys?Val?Asp?Asn?Thr?Lys?Val?Arg

470 475 480 485

gca?gaa?cag?ttg?gct?aaa?ctc?gcg?caa?ctg?aaa?gca?gag?cgc?aac?gat 1603

Ala?Glu?Gln?Leu?Ala?Lys?Leu?Ala?Gln?Leu?Lys?Ala?Glu?Arg?Asn?Asp

490 495 500

gcg?gaa?gtc?aag?gct?gcg?ctg?gat?gcg?ttg?aca?gct?gct?gcc?cgc?aac 1651

Ala?Glu?Val?Lys?Ala?Ala?Leu?Asp?Ala?Leu?Thr?Ala?Ala?Ala?Arg?Asn

505 510 515

gag?cat?aaa?gag?cca?ggg?gat?ttg?gat?cag?aac?ctg?ctc?aaa?ctt?gcc 1699

Glu?His?Lys?Glu?Pro?Gly?Asp?Leu?Asp?Gln?Asn?Leu?Leu?Lys?Leu?Ala

520 525 530

gtc?gat?gct?gcg?cgc?gca?aaa?gct?acc?att?gga?gag?atc?tcc?gat?gct 1747

Val?Asp?Ala?Ala?Arg?Ala?Lys?Ala?Thr?Ile?Gly?Glu?Ile?Ser?Asp?Ala

535 540 545

ttg?gaa?gtt?gtc?ttt?ggc?cgc?cac?gaa?gca?gaa?atc?agg?acg?ctg?tct 1795

Leu?Glu?Val?Val?Phe?Gly?Arg?His?Glu?Ala?Glu?Ile?Arg?Thr?Leu?Ser

550 555 560 565

ggc?gtg?tac?aag?gat?gag?gtt?gga?aag?gaa?ggc?aca?gtg?agc?aac?gtc 1843

Gly?Val?Tyr?Lys?Asp?Glu?Val?Gly?Lys?Glu?Gly?Thr?Val?Ser?Asn?Val

570 575 580

gaa?cgc?gcg?atc?gcc?ctg?gct?gac?gcc?ttt?gag?gct?gag?gaa?ggc?cgc 1891

Glu?Arg?Ala?Ile?Ala?Leu?Ala?Asp?Ala?Phe?Glu?Ala?Glu?Glu?Gly?Arg

585 590 595

cgc?cca?cgt?ate?ttt?att?gcc?aag?atg?ggc?cag?gat?gga?cat?gac?cgt 1939

Arg?Pro?Arg?Ile?Phe?Ile?Ala?Lys?Met?Gly?Gln?Asp?Gly?His?Asp?Arg

600 605 610

gga?cag?aag?gtt?gtc?gcg?tct?gcc?tat?gct?gac?ctg?ggc?atg?gac?gtg 1987

Gly?Gln?Lys?Val?Val?Ala?Ser?Ala?Tyr?Ala?Asp?Leu?Gly?Met?Asp?Val

615 620 625

gat?gtt?gga?ccg?ctg?ttt?caa?act?cca?gcc?gaa?gct?gcc?cgc?gcc?gcc 2035

Asp?Val?Gly?Pro?Leu?Phe?Gln?Thr?Pro?Ala?Glu?Ala?Ala?Arg?Ala?Ala

630 635 640 645

gtg?gac?gcc?gat?gtt?cac?gtg?gtg?ggt?atg?tct?tcg?ctg?gca?gca?ggc 2083

Val?Asp?Ala?Asp?Val?His?Val?Val?Gly?Met?Ser?Ser?Leu?Ala?Ala?Gly

650 655 660

cac?ctc?acc?ttg?ctg 2098

His?Leu?Thr?Leu?Leu

665

<210>630

<211>666

<212>PRT

＜213〉Corynebacterium glutamicum

<400>630

Met?Thr?Ser?Ile?Pro?Asn?Phe?Ser?Asp?Ile?Pro?Leu?Thr?Ala?Glu?Thr

1 5 10 15

Arg?Ala?Ser?Glu?Ser?His?Asn?Val?Asp?Ala?Gly?Lys?Val?Trp?Asn?Thr

20 25 30

Pro?Glu?Gly?Ile?Asp?Val?Lys?Arg?Val?Phe?Thr?Gln?Ala?Asp?Arg?Asp

35 40 45

Glu?Ala?Gln?Ala?Ala?Gly?His?Pro?Val?Asp?Ser?Leu?Pro?Gly?Gln?Lys

50 55 60

Pro?Phe?Met?Arg?Gly?Pro?Tyr?Pro?Thr?Met?Tyr?Thr?Asn?Gln?Pro?Trp

65 70 75 80

Thr?Ile?Arg?Gln?Tyr?Ala?Gly?Phe?Ser?Thr?Ala?Ala?Glu?Ser?Asn?Ala

85 90 95

Phe?Tyr?Arg?Arg?Asn?Leu?Ala?Ala?Gly?Gln?Lys?Gly?Leu?Ser?Val?Ala

100 105 110

Phe?Asp?Leu?Ala?Thr?His?Arg?Gly?Tyr?Asp?Ser?Asp?Asn?Glu?Arg?Val

115 120 125

Val?Gly?Asp?Val?Gly?Met?Ala?Gly?Val?Ala?Ile?Asp?Ser?Ile?Leu?Asp

130 135 140

Met?Arg?Gln?Leu?Phe?Asp?Gly?Ile?Asp?Leu?Ser?Ser?Val?Ser?Val?Ser

145 150 155 160

Met?Thr?Met?Asn?Gly?Ala?Val?Leu?Pro?Ile?Leu?Ala?Phe?Tyr?Ile?Val

165 170 175

Ala?Ala?Glu?Glu?Gln?Gly?Val?Gly?Pro?Glu?Gln?Leu?Ala?Gly?Thr?Ile

180 185 190

Gln?Asn?Asp?Ile?Leu?Lys?Glu?Phe?Met?Val?Arg?Asn?Thr?Tyr?Ile?Tyr

195 200 205

Pro?Pro?Lys?Pro?Ser?Met?Arg?Ile?Ile?Ser?Asn?Ile?Phe?Glu?Tyr?Thr

210 215 220

Ser?Leu?Lys?Met?Pro?Arg?Phe?Asn?Ser?Ile?Ser?Ile?Ser?Gly?Tyr?His

225 230 235 240

Ile?Gln?Glu?Ala?Gly?Ala?Thr?Ala?Asp?Leu?Glu?Leu?Ala?Tyr?Thr?Leu

245 250 255

Ala?Asp?Gly?Ile?Glu?Tyr?Ile?Arg?Ala?Gly?Lys?Glu?Val?Gly?Leu?Asp

260 265 270

Val?Asp?Lys?Phe?Ala?Pro?Arg?Leu?Ser?Phe?Phe?Trp?Gly?Ile?Ser?Met

275 280 285

Tyr?Thr?Phe?Met?Glu?Ile?Ala?Lys?Leu?Arg?Ala?Gly?Arg?Leu?Leu?Trp

290 295 300

Ser?Glu?Leu?Val?Ala?Lys?Phe?Asp?Pro?Lys?Asn?Ala?Lys?Ser?Gln?Ser

305 310 315 320

Leu?Arg?Thr?His?Ser?Gln?Thr?Ser?Gly?Trp?Ser?Leu?Thr?Ala?Gln?Asp

325 330 335

Val?Tyr?Asn?Asn?Val?Ala?Arg?Thr?Ala?Ile?Glu?Ala?Met?Ala?Ala?Thr

340 345 350

Gln?Gly?His?Thr?Gln?Ser?Leu?His?Thr?Asn?Ala?Leu?Asp?Glu?Ala?Leu

355 360 365

Ala?Leu?Pro?Thr?Asp?Phe?Ser?Ala?Arg?Ile?Ala?Arg?Asn?Thr?Gln?Leu

370 375 380

Leu?Leu?Gln?Gln?Glu?Ser?Gly?Thr?Val?Arg?Pro?Val?Asp?Pro?Trp?Ala

385 390 395 400

Gly?Ser?Tyr?Tyr?Val?Glu?Trp?Leu?Thr?Asn?Glu?Leu?Ala?Asn?Arg?Ala

405 410 415

Arg?Lys?His?Ile?Asp?Glu?Val?Glu?Glu?Ala?Gly?Gly?Met?Ala?Gln?Ala

420 425 430

Thr?Ala?Gln?Gly?Ile?Pro?Lys?Leu?Arg?Ile?Glu?Glu?Ser?Ala?Ala?Arg

435 440 445

Thr?Gln?Ala?Arg?Ile?Asp?Ser?Gly?Arg?Gln?Ala?Leu?Ile?Gly?Val?Asn

450 455 460

Arg?Tyr?Val?Ala?Glu?Glu?Asp?Glu?Glu?Ile?Glu?Val?Leu?Lys?Val?Asp

465 470 475 480

Asn?Thr?Lys?Val?Arg?Ala?Glu?Gln?Leu?Ala?Lys?Leu?Ala?Gln?Leu?Lys

485 490 495

Ala?Glu?Arg?Asn?Asp?Ala?Glu?Val?Lys?Ala?Ala?Leu?Asp?Ala?Leu?Thr

500 505 510

Ala?Ala?Ala?Arg?Asn?Glu?His?Lys?Glu?Pro?Gly?Asp?Leu?Asp?Gln?Asn

515 520 525

Leu?Leu?Lys?Leu?Ala?Val?Asp?Ala?Ala?Arg?Ala?Lys?Ala?Thr?Ile?Gly

530 535 540

Glu?Ile?Ser?Asp?Ala?Leu?Glu?Val?Val?Phe?Gly?Arg?His?Glu?Ala?Glu

545 550 555 560

Ile?Arg?Thr?Leu?Ser?Gly?Val?Tyr?Lys?Asp?Glu?Val?Gly?Lys?Glu?Gly

565 570 575

Thr?Val?Ser?Asn?Val?Glu?Arg?Ala?Ile?Ala?Leu?Ala?Asp?Ala?Phe?Glu

580 585 590

Ala?Glu?Glu?Gly?Arg?Arg?Pro?Arg?Ile?Phe?Ile?Ala?Lys?Met?Gly?Gln

595 600 605

Asp?Gly?His?Asp?Arg?Gly?Gln?Lys?Val?Val?Ala?Ser?Ala?Tyr?Ala?Asp

610 615 620

Leu?Gly?Met?Asp?Val?Asp?Val?Gly?Pro?Leu?Phe?Gln?Thr?Pro?Ala?Glu

625 630 635 640

Ala?Ala?Arg?Ala?Ala?Val?Asp?Ala?Asp?Val?His?Val?Val?Gly?Met?Ser

645 650 655

Ser?Leu?Ala?Ala?Gly?His?Leu?Thr?Leu?Leu

660 665

<210>631

<211>1971

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1948)

<223>RXA00149

<400>631

ttttcgtagg?taaacacagg?tgaaggcttt?acaagcttgt?gaactcccta?cacaaaagca?60

atccaatagc?tatccataag?caagagaaag?taagtctacg?ttg?act?gat?ctc?aca 115

Leu?Thr?Asp?Leu?Thr

1 5

aag?act?gcg?gtg?ccc?gag?gaa?ctt?tca?gag?aac?ctc?gaa?act?tgg?tac 163

Lys?Thr?Ala?Val?Pro?Glu?Glu?Leu?Ser?Glu?Asn?Leu?Glu?Thr?Trp?Tyr

10 15 20

aag?gct?gtg?gcc?ggt?gtt?ttc?gcg?cgc?aca?cag?aaa?aaa?gac?atc?ggc 211

Lys?Ala?Val?Ala?Gly?Val?Phe?Ala?Arg?Thr?Gln?Lys?Lys?Asp?Ile?Gly

25 30 35

gac?att?gcc?gta?gat?gtg?tgg?aag?aaa?ctc?atc?gtc?act?aca?ccg?gat 259

Asp?Ile?Ala?Val?Asp?Val?Trp?Lys?Lys?Leu?Ile?Val?Thr?Thr?Pro?Asp

40 45 50

ggt?gtt?gat?atc?aat?ccg?ctg?tac?acc?aga?gca?gat?gag?tcc?cag?agg 307

Gly?Val?Asp?Ile?Asn?Pro?Leu?Tyr?Thr?Arg?Ala?Asp?Glu?Ser?Gln?Arg

55 60 65

aaa?ttc?act?gag?gtt?cct?ggt?gag?ttt?ccc?ttc?act?agg?gga?acc?act 355

Lys?Phe?Thr?Glu?Val?Pro?Gly?Glu?Phe?Pro?Phe?Thr?Arg?Gly?Thr?Thr

70 75 80 85

gtt?gat?ggt?gaa?cgc?gtt?ggt?tgg?ggt?gtt?act?gag?act?ttc?gga?cat 403

Val?Asp?Gly?Glu?Arg?Val?Gly?Trp?Gly?Val?Thr?Glu?Thr?Phe?Gly?His

90 95 100

gac?agc?ccg?aag?aat?atc?aac?gct?gcg?gtg?ctg?aat?gct?ctg?aat?tct 451

Asp?Ser?Pro?Lys?Asn?Ile?Asn?Ala?Ala?Val?Leu?Asn?Ala?Leu?Asn?Ser

105 110 115

ggc?acc?acc?aca?ttg?ggt?ttt?gag?ttc?tct?gag?gaa?ttc?acg?gca?gct 499

Gly?Thr?Thr?Thr?Leu?Gly?Phe?Glu?Phe?Ser?Glu?Glu?Phe?Thr?Ala?Ala

120 125 130

gat?ctt?aaa?gtt?gct?ctc?gaa?ggc?gtg?tat?ctc?aac?atg?gct?ccg?ttg 547

Asp?Leu?Lys?Val?Ala?Leu?Glu?Gly?Val?Tyr?Leu?Asn?Met?Ala?Pro?Leu

135 140 145

ctg?att?cat?gcg?ggt?gga?tcc?acg?tca?gag?gtt?gca?gcg?gcg?ttg?tat 595

Leu?Ile?His?Ala?Gly?Gly?Ser?Thr?Ser?Glu?Val?Ala?Ala?Ala?Leu?Tyr

150 155 160 165

acg?ttg?gcg?gag?gaa?gcc?gga?acg?ttt?ttt?gct?gcg?ttg?acc?ttg?ggt 643

Thr?Leu?Ala?Glu?Glu?Ala?Gly?Thr?Phe?Phe?Ala?Ala?Leu?Thr?Leu?Gly

170 175 180

tct?cgt?cct?ttg?acg?gcg?cag?gtt?gat?ggt?tcg?cac?agt?gac?acc?att 691

Ser?Arg?Pro?Leu?Thr?Ala?Gln?Val?Asp?Gly?Ser?His?Ser?Asp?Thr?Ile

185 190 195

gaa?gaa?gca?gtt?cag?ttg?gca?gtg?aat?gct?tcc?aag?cgt?gcg?aat?gtg 739

Glu?Glu?Ala?Val?Gln?Leu?Ala?Val?Asn?Ala?Ser?Lys?Arg?Ala?Asn?Val

200 205 210

cgc?gct?atc?ttg?gtg?gat?ggt?tcc?agt?ttt?tcc?aac?cag?ggc?gcg?tcg 787

Arg?Ala?Ile?Leu?Val?Asp?Gly?Ser?Ser?Phe?Ser?Asn?Gln?Gly?Ala?Ser

215 220 225

gat?gct?caa?gaa?att?ggt?cta?agt?atc?gcc?gcc?ggt?gtg?gat?tat?gtc 835

Asp?Ala?Gln?Glu?Ile?Gly?Leu?Ser?Ile?Ala?Ala?Gly?Val?Asp?Tyr?Val

230 235 240 245

cgt?cgc?ttg?gtc?gat?gca?ggc?ctt?tcc?acg?gaa?gct?gca?ctt?aag?cag 883

Arg?Arg?Leu?Val?Asp?Ala?Gly?Leu?Ser?Thr?Glu?Ala?Ala?Leu?Lys?Gln

250 255 260

gtg?gcg?ttc?cgt?ttt?gcg?gtc?acc?gat?gag?cag?ttc?gcg?cag?att?tct 931

Val?Ala?Phe?Arg?Phe?Ala?Val?Thr?Asp?Glu?Gln?Phe?Ala?Gln?Ile?Ser

265 270 275

aag?ctg?cgt?gtg?gct?cga?cgt?ctg?tgg?gcc?agg?gtg?tgt?gag?gtg?ctt 979

Lys?Leu?Arg?Val?Ala?Arg?Arg?Leu?Trp?Ala?Arg?Val?Cys?Glu?Val?Leu

280 285 290

ggt?ttt?cca?gag?ctg?gcc?gta?gca?cca?cag?cat?gcg?gtg?act?gca?cga 1027

Gly?Phe?Pro?Glu?Leu?Ala?Val?Ala?Pro?Gln?His?Ala?Val?Thr?Ala?Arg

295 300 305

gcg?atg?ttt?agc?cag?cgt?gat?ccg?tgg?gtg?aat?atg?ctg?cgc?agt?act 1075

Ala?Met?Phe?Ser?Gln?Arg?Asp?Pro?Trp?Val?Asn?Met?Leu?Arg?Ser?Thr

310 315 320 325

gtt?gca?gct?ttc?gct?gca?ggc?gtc?ggt?gga?gca?acc?gat?gtg?gag?gtt 1123

Val?Ala?Ala?Phe?Ala?Ala?Gly?Val?Gly?Gly?Ala?Thr?Asp?Val?Glu?Val

330 335 340

cgt?act?ttt?gat?gat?gcg?atc?cca?gat?gga?gtt?cct?gga?gtg?tcg?agg 1171

Arg?Thr?Phe?Asp?Asp?Ala?Ile?Pro?Asp?Gly?Val?Pro?Gly?Val?Ser?Arg

345 350 355

aat?ttc?gct?cac?cgc?atc?gcg?cgc?aat?act?aat?ttg?ttg?ttg?cta?gaa 1219

Asn?Phe?Ala?His?Arg?Ile?Ala?Arg?Asn?Thr?Asn?Leu?Leu?Leu?Leu?Glu

360 365 370

gag?tca?cat?ctt?ggt?cac?gtg?gtt?gat?cct?gct?ggt?gga?tca?tat?ttc 1267

Glu?Ser?His?Leu?Gly?His?Val?Val?Asp?Pro?Ala?Gly?Gly?Ser?Tyr?Phe

375 380 385

gtg?gag?agc?ttc?acc?gat?gat?cta?gcg?gag?aag?gcg?tgg?gct?gtg?ttc 1315

Val?Glu?Ser?Phe?Thr?Asp?Asp?Leu?Ala?Glu?Lys?Ala?Trp?Ala?Val?Phe

390 395 400 405

agt?ggc?atc?gaa?gct?gag?ggc?gga?tac?agt?gca?gct?tgt?gca?tcc?ggc 1363

Ser?Gly?Ile?Glu?Ala?Glu?Gly?Gly?Tyr?Ser?Ala?Ala?Cys?Ala?Ser?Gly

410 415 420

acg?gtg?act?gcc?atg?ctt?gat?cag?acg?tgg?gag?cag?act?cgc?gct?gat 1411

Thr?Val?Thr?Ala?Met?Leu?Asp?Gln?Thr?Trp?Glu?Gln?Thr?Arg?Ala?Asp

425 430 435

gtg?gcg?tcg?aga?aag?aag?aag?ctc?act?gga?att?aat?gag?ttc?ccg?aac 1459

Val?Ala?Ser?Arg?Lys?Lys?Lys?Leu?Thr?Gly?Ile?Asn?Glu?Phe?Pro?Asn

440 445 450

ttg?gcg?gag?tct?ccg?ctg?cca?gct?gat?cgt?cgg?gta?gaa?cct?gca?ggt 1507

Leu?Ala?Glu?Ser?Pro?Leu?Pro?Ala?Asp?Arg?Arg?Val?Glu?Pro?Ala?Gly

455 460 465

gtg?cgt?cga?tgg?gca?gcg?gat?ttt?gaa?gcg?ctg?cgc?aat?cgt?tcg?gat 1555

Val?Arg?Arg?Trp?Ala?Ala?Asp?Phe?Glu?Ala?Leu?Arg?Asn?Arg?Ser?Asp

470 475 480 485

gct?ttc?ttg?gaa?aag?aac?ggc?gcg?agg?cca?cag?atc?acg?atg?att?cct 1603

Ala?Phe?Leu?Glu?Lys?Asn?Gly?Ala?Arg?Pro?Gln?Ile?Thr?Met?Ile?Pro

490 495 500

ctg?gga?ccg?ttg?tcc?aag?cac?aat?att?cgc?act?ggt?ttt?act?tcc?aac 1651

Leu?Gly?Pro?Leu?Ser?Lys?His?Asn?Ile?Arg?Thr?Gly?Phe?Thr?Ser?Asn

505 510 515

ctg?ttg?gct?tcc?ggt?ggc?att?gaa?gca?atc?aac?ccg?ggt?caa?ctt?gtt 1699

Leu?Leu?Ala?Ser?Gly?Gly?Ile?Glu?Ala?Ile?Asn?Pro?Gly?Gln?Leu?Val

520 525 530

ccc?ggc?act?gac?gct?ttt?gca?gaa?gct?gca?cag?gcc?gca?ggc?att?gta 1747

Pro?Gly?Thr?Asp?Ala?Phe?Ala?Glu?Ala?Ala?Gln?Ala?Ala?Gly?Ile?Val

535 540 545

gtg?gtg?tgt?gga?acg?gac?caa?gag?tat?gcc?gaa?acg?ggg?gag?gga?gcc 1795

Val?Val?Cys?Gly?Thr?Asp?Gln?Glu?Tyr?Ala?Glu?Thr?Gly?Glu?Gly?Ala

550 555 560 565

gtc?gaa?aag?ctc?cgc?gaa?gcg?ggc?gtt?gag?cgc?atc?ctg?ctt?gct?ggc 1843

Val?Glu?Lys?Leu?Arg?Glu?Ala?Gly?Val?Glu?Arg?Ile?Leu?Leu?Ala?Gly

570 575 580

gcg?ccg?aag?agc?ttt?gag?ggc?agc?gcg?cat?gcg?ccc?gat?ggt?tat?ttg 1891

Ala?Pro?Lys?Ser?Phe?Glu?Gly?Ser?Ala?His?Ala?Pro?Asp?Gly?Tyr?Leu

585 590 595

aac?atg?aca?att?gat?gcc?gcg?gcg?acg?ctg?gct?gac?ctg?cta?gat?gct 1939

Asn?Met?Thr?Ile?Asp?Ala?Ala?Ala?Thr?Leu?Ala?Asp?Leu?Leu?Asp?Ala

600 605 610

ttg?gga?gct?taaatcatga?cgtcgatccc?taa 1971

Leu?Gly?Ala

615

<210>632

<211>616

<212>PRT

＜213〉Corynebacterium glutamicum

<400>632

Leu?Thr?Asp?Leu?Thr?Lys?Thr?Ala?Val?Pro?Glu?Glu?Leu?Ser?Glu?Asn

1 5 10 15

Leu?Glu?Thr?Trp?Tyr?Lys?Ala?Val?Ala?Gly?Val?Phe?Ala?Arg?Thr?Gln

20 25 30

Lys?Lys?Asp?Ile?Gly?Asp?Ile?Ala?Val?Asp?Val?Trp?Lys?Lys?Leu?Ile

35 40 45

Val?Thr?Thr?Pro?Asp?Gly?Val?Asp?Ile?Asn?Pro?Leu?Tyr?Thr?Arg?Ala

50 55 60

Asp?Glu?Ser?Gln?Arg?Lys?Phe?Thr?Glu?Val?Pro?Gly?Glu?Phe?Pro?Phe

65 70 75 80

Thr?Arg?Gly?Thr?Thr?Val?Asp?Gly?Glu?Arg?Val?Gly?Trp?Gly?Val?Thr

85 90 95

Glu?Thr?Phe?Gly?His?Asp?Ser?Pro?Lys?Asn?Ile?Asn?Ala?Ala?Val?Leu

100 105 110

Asn?Ala?Leu?Asn?Ser?Gly?Thr?Thr?Thr?Leu?Gly?Phe?Glu?Phe?Ser?Glu

115 120 125

Glu?Phe?Thr?Ala?Ala?Asp?Leu?Lys?Val?Ala?Leu?Glu?Gly?Val?Tyr?Leu

130 135 140

Asn?Met?Ala?Pro?Leu?Leu?Ile?His?Ala?Gly?Gly?Ser?Thr?Ser?Glu?Val

145 150 155 160

Ala?Ala?Ala?Leu?Tyr?Thr?Leu?Ala?Glu?Glu?Ala?Gly?Thr?Phe?Phe?Ala

165 170 175

Ala?Leu?Thr?Leu?Gly?Ser?Arg?Pro?Leu?Thr?Ala?Gln?Val?Asp?Gly?Ser

180 185 190

His?Ser?Asp?Thr?Ile?Glu?Glu?Ala?Val?Gln?Leu?Ala?Val?Asn?Ala?Ser

195 200 205

Lys?Arg?Ala?Asn?Val?Arg?Ala?Ile?Leu?Val?Asp?Gly?Ser?Ser?Phe?Ser

210 215 220

Asn?Gln?Gly?Ala?Ser?Asp?Ala?Gln?Glu?Ile?Gly?Leu?Ser?Ile?Ala?Ala

225 230 235 240

Gly?Val?Asp?Tyr?Val?Arg?Arg?Leu?Val?Asp?Ala?Gly?Leu?Ser?Thr?Glu

245 250 255

Ala?Ala?Leu?Lys?Gln?Val?Ala?Phe?Arg?Phe?Ala?Val?Thr?Asp?Glu?Gln

260 265 270

Phe?Ala?Gln?Ile?Ser?Lys?Leu?Arg?Val?Ala?Arg?Arg?Leu?Trp?Ala?Arg

275 280 285

Val?Cys?Glu?Val?Leu?Gly?Phe?Pro?Glu?Leu?Ala?Val?Ala?Pro?Gln?His

290 295 300

Ala?Val?Thr?Ala?Arg?Ala?Met?Phe?Ser?Gln?Arg?Asp?Pro?Trp?Val?Asn

305 310 315 320

Met?Leu?Arg?Ser?Thr?Val?Ala?Ala?Phe?Ala?Ala?Gly?Val?Gly?Gly?Ala

325 330 335

Thr?Asp?Val?Glu?Val?Arg?Thr?Phe?Asp?Asp?Ala?Ile?Pro?Asp?Gly?Val

340 345 350

Pro?Gly?Val?Ser?Arg?Asn?Phe?Ala?His?Arg?Ile?Ala?Arg?Asn?Thr?Asn

355 360 365

Leu?Leu?Leu?Leu?Glu?Glu?Ser?His?Leu?Gly?His?Val?Val?Asp?Pro?Ala

370 375 380

Gly?Gly?Ser?Tyr?Phe?Val?Glu?Ser?Phe?Thr?Asp?Asp?Leu?Ala?Glu?Lys

385 390 395 400

Ala?Trp?Ala?Val?Phe?Ser?Gly?Ile?Glu?Ala?Glu?Gly?Gly?Tyr?Ser?Ala

405 410 415

Ala?Cys?Ala?Ser?Gly?Thr?Val?Thr?Ala?Met?Leu?Asp?Gln?Thr?Trp?Glu

420 425 430

Gln?Thr?Arg?Ala?Asp?Val?Ala?Ser?Arg?Lys?Lys?Lys?Leu?Thr?Gly?Ile

435 440 445

Asn?Glu?Phe?Pro?Asn?Leu?Ala?Glu?Ser?Pro?Leu?Pro?Ala?Asp?Arg?Arg

450 455 460

ValGlu?Pro?Ala?Gly?Val?Arg?Arg?Trp?Ala?Ala?Asp?Phe?Glu?Ala?Leu

465 470 475 480

Arg?Asn?Arg?Ser?Asp?Ala?Phe?Leu?Glu?Lys?Asn?Gly?Ala?Arg?Pro?Gln

485 490 495

Ile?Thr?Met?Ile?Pro?Leu?Gly?Pro?Leu?Ser?Lys?His?Asn?Ile?Arg?Thr

500 505 510

Gly?Phe?Thr?Ser?Asn?Leu?Leu?Ala?Ser?Gly?Gly?Ile?Glu?Ala?Ile?Asn

515 520 525

Pro?Gly?Gln?Leu?Val?Pro?Gly?Thr?Asp?Ala?Phe?Ala?Glu?Ala?Ala?Gln

530 535 540

Ala?Ala?Gly?Ile?Val?Val?Val?Cys?Gly?Thr?Asp?Gln?Glu?Tyr?Ala?Glu

545 550 555 560

Thr?Gly?Glu?Gly?Ala?Val?Glu?Lys?Leu?Arg?Glu?Ala?Gly?Val?Glu?Arg

565 570 575

Ile?Leu?Leu?Ala?Gly?Ala?Pro?Lys?Ser?Phe?Glu?Gly?Ser?Ala?His?Ala

580 585 590

Pro?Asp?Gly?Tyr?Leu?Asn?Met?Thr?Ile?Asp?Ala?Ala?Ala?Thr?Leu?Ala

595 600 605

Asp?Leu?Leu?Asp?Ala?Leu?Gly?Ala

610 615

<210>633

<211>777

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(754)

<223>RXN00317

<400>633

caacggttac?atcactcacg?cattaactcc?cctggttggt?accgcatgtt?cgtttcccaa?60

gtctagccaa?gccttgaaaa?attctggcaa?ggttaatggt?gtg?act?acg?cct?tct 115

Val?Thr?Thr?Pro?Ser

1 5

aag?aaa?act?ctg?ctc?ttt?gat?ctc?gac?gga?acc?ctc?gtc?gat?tct?ttc 163

Lys?Lys?Thr?Leu?Leu?Phe?Asp?Leu?Asp?Gly?Thr?Leu?Val?Asp?Ser?Phe

10 15 20

ccc?ggt?atc?cgc?act?tca?ttc?ctt?cac?acc?ctg?cac?gaa?aag?aac?tgg 211

Pro?Gly?Ile?Arg?Thr?Ser?Phe?Leu?His?Thr?Leu?His?Glu?Lys?Asn?Trp

25 30 35

gaa?atc?ccc?tct?gag?gaa?cgc?atc?tcg?caa?gtt?cca?gga?cct?ccc?atg 259

Glu?Ile?Pro?Ser?Glu?Glu?Arg?Ile?Ser?Gln?Val?Pro?Gly?Pro?Pro?Met

40 45 50

gaa?tgg?acg?ttc?cag?gat?ttg?ggc?atg?act?cca?gag?cag?gca?caa?gac 307

Glu?Trp?Thr?Phe?Gln?Asp?Leu?Gly?Met?Thr?Pro?Glu?Gln?Ala?Gln?Asp

55 60 65

gct?ctg?cag?acc?tac?ctt?gag?cat?tac?ggc?cag?gtg?ggt?tgg?gat?ctt 355

Ala?Leu?Gln?Thr?Tyr?Leu?Glu?His?Tyr?Gly?Gln?Val?Gly?Trp?Asp?Leu

70 75 80 85

tcc?gaa?gca?ttc?ccc?ggc?atg?cga?gat?ttg?ctg?atc?cgc?ttg?aaa?tac 403

Ser?Glu?Ala?Phe?Pro?Gly?Met?Arg?Asp?Leu?Leu?Ile?Arg?Leu?Lys?Tyr

90 95 100

gaa?ggt?ttc?cgt?ctg?tgc?acc?gcc?acc?tcc?aag?ggc?gag?ttc?ttt?gcg 451

Glu?Gly?Phe?Arg?Leu?Cys?Thr?Ala?Thr?Ser?Lys?Gly?Glu?Phe?Phe?Ala

105 110 115

gag?aag?gta?ctt?cgc?aaa?ttc?gag?atg?ttc?gat?ctc?ttc?gaa?ttc?atg 499

Glu?Lys?Val?Leu?Arg?Lys?Phe?Glu?Met?Phe?Asp?Leu?Phe?Glu?Phe?Met

120 125 130

ggt?gcc?gcc?acc?gac?agc?ggc?aac?cga?cgc?agc?aaa?tct?gcc?gtg?atc 547

Gly?Ala?Ala?Thr?Asp?Ser?Gly?Asn?Arg?Arg?Ser?Lys?Ser?Ala?Val?Ile

135 140 145

aaa?cat?gtc?ctc?gac?agc?gtt?ggg?ttg?gac?gaa?cca?aat?gat?att?ttg 595

Lys?His?Val?Leu?Asp?Ser?Val?Gly?Leu?Asp?Glu?Pro?Asn?Asp?Ile?Leu

150 155 160 165

atg?att?ggt?gat?cga?tca?cac?gat?att?gaa?ggt?tcg?agt?gaa?ttc?ggc 643

Met?Ile?Gly?Asp?Arg?Ser?His?Asp?Ile?Glu?Gly?Ser?Ser?Glu?Phe?Gly

170 175 180

atc?gat?tgt?gtt?gcc?gta?acc?tgg?ggc?tac?ggc?agc?aaa?act?gaa?tgg 691

Ile?Asp?Cys?Val?Ala?Val?Thr?Trp?Gly?Tyr?Gly?Ser?Lys?Thr?Glu?Trp

185 190 195

gac?gct?gcc?cgc?tac?acc?gtg?agc?acc?gca?gaa?gaa?tta?gaa?agg?atc 739

Asp?Ala?Ala?Arg?Tyr?Thr?Val?Ser?Thr?Ala?Glu?Glu?Leu?Glu?Arg?Ile

200 205 210

atc?cat?gac?tgg?gcc?taaaacttcg?ctacctgtgg?aaa 777

Ile?His?Asp?Trp?Ala

215

<210>634

<211>218

<212>PRT

＜213〉Corynebacterium glutamicum

<400>634

Val?Thr?Thr?Pro?Ser?Lys?Lys?Thr?Leu?Leu?Phe?Asp?Leu?Asp?Gly?Thr

1 5 10 15

Leu?Val?Asp?Ser?Phe?Pro?Gly?Ile?Arg?Thr?Ser?Phe?Leu?His?Thr?Leu

20 25 30

His?Glu?Lys?Asn?Trp?Glu?Ile?Pro?Ser?Glu?Glu?Arg?Ile?Ser?Gln?Val

35 40 45

Pro?Gly?Pro?Pro?Met?Glu?Trp?Thr?Phe?Gln?Asp?Leu?Gly?Met?Thr?Pro

50 55 60

Glu?Gln?Ala?Gln?Asp?Ala?Leu?Gln?Thr?Tyr?Leu?Glu?His?Tyr?Gly?Gln

65 70 75 80

Val?Gly?Trp?Asp?Leu?Ser?Glu?Ala?Phe?Pro?Gly?Met?Arg?Asp?Leu?Leu

85 90 95

Ile?Arg?Leu?Lys?Tyr?Glu?Gly?Phe?Arg?Leu?Cys?Thr?Ala?Thr?Ser?Lys

100 105 110

Gly?Glu?Phe?Phe?Ala?Glu?Lys?Val?Leu?Arg?Lys?Phe?Glu?Met?Phe?Asp

115 120 125

Leu?Phe?Glu?Phe?Met?Gly?Ala?Ala?Thr?Asp?Ser?Gly?Asn?Arg?Arg?Ser

130 135 140

Lys?Ser?Ala?Val?Ile?Lys?His?Val?Leu?Asp?Ser?Val?Gly?Leu?Asp?Glu

145 150 155 160

Pro?Asn?Asp?Ile?Leu?Met?Ile?Gly?Asp?Arg?Ser?His?Asp?Ile?Glu?Gly

165 170 175

Ser?Ser?Glu?Phe?Gly?Ile?Asp?Cys?Val?Ala?Val?Thr?Trp?Gly?Tyr?Gly

180 185 190

Ser?Lys?Thr?Glu?Trp?Asp?Ala?Ala?Arg?Tyr?Thr?Val?Ser?Thr?Ala?Glu

195 200 205

Glu?Leu?Glu?Arg?Ile?Ile?His?Asp?Trp?Ala

210 215

<210>635

<211>439

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(439)

<223>FRXA00317

<400>635

caacggttac?atcactcacg?cattacctcc?cctggttggt?accgcatgtt?cgtttcccaa?60

gtcaagccaa?gccttgaaaa?attctggcaa?ggttaatggt?gtg?act?acg?cct?tct 115

Val?Thr?Thr?Pro?Ser

1 5

aag?aaa?act?ctg?ctc?ttt?gat?ctc?gac?gga?acc?ctc?gtc?gat?tct?ttc 163

Lys?Lys?Thr?Leu?Leu?Phe?Asp?Leu?Asp?Gly?Thr?Leu?Val?Asp?Ser?Phe

10 15 20

ccc?ggt?atc?cgc?act?tca?ttc?ctt?cac?acc?ctg?cac?gaa?aag?aac?tgg 211

Pro?Gly?Ile?Arg?Thr?Ser?Phe?Leu?His?Thr?Leu?His?Glu?Lys?Asn?Trp

25 30 35

gaa?atc?ccc?tct?gag?gaa?cgc?atc?tcg?caa?gtt?cca?gga?cct?ccc?atg 259

Glu?Ile?Pro?Ser?Glu?Glu?Arg?Ile?Ser?Gln?Val?Pro?Gly?Pro?Pro?Met

40 45 50

gaa?tgg?acg?ttc?cag?gat?ttg?ggc?atg?act?cca?gag?cag?gca?caa?gac 307

Glu?Trp?Thr?Phe?Gln?Asp?Leu?Gly?Met?Thr?Pro?Glu?Gln?Ala?Gln?Asp

55 60 65

gct?ctg?cag?acc?tac?ctt?gag?cat?tac?ggc?cag?gtg?ggt?tgg?gat?ctt 355

Ala?Leu?Gln?Thr?Tyr?Leu?Glu?His?Tyr?Gly?Gln?Val?Gly?Trp?Asp?Leu

70 75 80 85

tcc?gaa?gca?ttc?ccc?ggc?atg?cga?gat?ttg?ctg?atc?ccc?ttg?ata?tac 403

Ser?Glu?Ala?Phe?Pro?Gly?Met?Arg?Asp?Leu?Leu?Ile?Pro?Leu?Ile?Tyr

90 95 100

gaa?ggt?ttt?cgt?ctg?tgc?acc?gcc?acc?ttt?caa?ggg 439

Glu?Gly?Phe?Arg?Leu?Cys?Thr?Ala?Thr?Phe?Gln?Gly

105 110

<210>636

<211>113

<212>PRT

＜213〉Corynebacterium glutamicum

<400>636

Val?Thr?Thr?Pro?Ser?Lys?Lys?Thr?Leu?Leu?Phe?Asp?Leu?Asp?Gly?Thr

1 5 10 15

Leu?Val?Asp?Ser?Phe?Pro?Gly?Ile?Arg?Thr?Ser?Phe?Leu?His?Thr?Leu

20 25 30

His?Glu?Lys?Asn?Trp?Glu?Ile?Pro?Ser?Glu?Glu?Arg?Ile?Ser?Gln?Val

35 40 45

Pro?Gly?Pro?Pro?Met?Glu?Trp?Thr?Phe?Gln?Asp?Leu?Gly?Met?Thr?Pro

50 55 60

Glu?Gln?Ala?Gln?Asp?Ala?Leu?Gln?Thr?Tyr?Leu?Glu?His?Tyr?Gly?Gln

65 70 75 80

Val?Gly?Trp?Asp?Leu?Ser?Glu?Ala?Phe?Pro?Gly?Met?Arg?Asp?Leu?Leu

85 90 95

Ile?Pro?Leu?Ile?Tyr?Glu?Gly?Phe?Arg?Leu?Cys?Thr?Ala?Thr?Phe?Gln

100 105 110

Gly

<210>637

<211>816

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(793)

<223>RXA02196

<400>637

tctaccaccc?agaggcaaag?tactttaacg?tctaacacct?ttgagaggga?aaactttccc?60

gcacattgca?gatcgtgcca?ctttaactaa?ggttgacggc?atg?att?aag?gcg?att 115

Met?Ile?Lys?Ala?Ile

1 5

ttc?tgg?gac?atg?gac?ggc?acg?atg?gtg?gac?tct?gag?cca?cag?tgg?ggc 163

Phe?Trp?Asp?Met?Asp?Gly?Thr?Met?Val?Asp?Ser?Glu?Pro?Gln?Trp?Gly

10 15 20

att?gct?acc?tac?gag?ctc?agc?gaa?gcc?atg?ggc?cgc?cgc?ctc?acc?ccg 211

Ile?Ala?Thr?Tyr?Glu?Leu?Ser?Glu?Ala?Met?Gly?Arg?Arg?Leu?Thr?Pro

25 30 35

gag?ctc?cgg?gaa?ctc?acc?gtc?ggc?tcg?agc?ctg?ccg?cgc?acc?atg?cgc 259

Glu?Leu?Arg?Glu?Leu?Thr?Val?Gly?Ser?Ser?Leu?Pro?Arg?Thr?Met?Arg

40 45 50

tta?tgc?gca?gag?cac?gca?ggc?att?aca?ttg?agc?gac?gcg?gac?tac?gag 307

Leu?Cys?Ala?Glu?His?Ala?Gly?Ile?Thr?Leu?Ser?Asp?Ala?Asp?Tyr?Glu

55 60 65

cgc?tac?cgg?gct?ggc?atg?ttc?gcc?cgg?gtc?cat?gag?ctt?ttc?gac?gaa 355

Arg?Tyr?Arg?Ala?Gly?Met?Phe?Ala?Arg?Val?His?Glu?Leu?Phe?Asp?Glu

70 75 80 85

tcc?ctc?gtc?cca?aat?cca?ggc?gtc?acc?gaa?ctc?ctg?aca?gag?ttg?aag 403

Ser?Leu?Val?Pro?Asn?Pro?Gly?Val?Thr?Glu?Leu?Leu?Thr?Glu?Leu?Lys

90 95 100

gcc?ctc?gag?atc?ccc?atg?ttg?gtc?acc?acc?aac?aca?gag?cgc?gat?ctc 451

Ala?Leu?Glu?Ile?Pro?Met?Leu?Val?Thr?Thr?Asn?Thr?Glu?Arg?Asp?Leu

105 110 115

gcg?acc?cgt?tca?gtc?gca?gcc?gtg?gga?aat?gag?ttc?ttc?atc?ggt?tct 499

Ala?Thr?Arg?Ser?Val?Ala?Ala?Val?Gly?Asn?Glu?Phe?Phe?Ile?Gly?Ser

120 125 130

atc?gct?ggt?gat?gaa?gtc?cca?aca?gca?aag?cca?gcc?ccc?gac?atg?tac 547

Ile?Ala?Gly?Asp?Glu?Val?Pro?Thr?Ala?Lys?Pro?Ala?Pro?Asp?Met?Tyr

135 140 145

ctc?gaa?gca?gca?cga?cgt?gtg?ggc?ttt?gac?cca?tca?gag?tgc?ctc?gtg 595

Leu?Glu?Ala?Ala?Arg?Arg?Val?Gly?Phe?Asp?Pro?Ser?Glu?Cys?Leu?Val

150 155 160 165

ttc?gaa?gat?tcc?tac?aac?ggc?atg?ctg?ggc?gct?gtt?act?gca?ggt?tgc 643

Phe?Glu?Asp?Ser?Tyr?Asn?Gly?Met?Leu?Gly?Ala?Val?Thr?Ala?Gly?Cys

170 175 180

cgc?gtc?att?ggt?ctg?cac?cca?gaa?gaa?gtc?caa?gcg?cca?gaa?ggt?gta 691

Arg?Val?Ile?Gly?Leu?His?Pro?Glu?Glu?Val?Gln?Ala?Pro?Glu?Gly?Val

185 190 195

gtg?cct?ttg?cgt?tcc?ctc?cac?ggt?aaa?aac?tct?ttc?gaa?ggt?gtc?acc 739

Val?Pro?Leu?Arg?Ser?Leu?His?Gly?Lys?Asn?Ser?Phe?Glu?Gly?ValThr

200 205 210

gct?gag?atg?gtc?act?gcc?tgg?tac?cac?cag?atc?gag?ccg?gca?ggt?gtc 787

Ala?Glu?Met?Val?Thr?Ala?Trp?Tyr?His?Gln?Ile?Glu?Pro?Ala?Gly?Val

215 220 225

gca?aaa?taaaaccagg?tgggggagtg?aaa 816

Ala?Lys

230

<210>638

<211>231

<212>PRT

＜213〉Corynebacterium glutamicum

<400>638

Met?Ile?Lys?Ala?Ile?Phe?Trp?Asp?Met?Asp?Gly?Thr?Met?Val?Asp?Ser

1 5 10 15

Glu?Pro?Gln?Trp?Gly?Ile?Ala?Thr?Tyr?Glu?Leu?Ser?Glu?Ala?Met?Gly

20 25 30

Arg?Arg?Leu?Thr?Pro?Glu?Leu?Arg?Glu?Leu?Thr?Val?Gly?Ser?Ser?Leu

35 40 45

Pro?Arg?Thr?Met?Arg?Leu?Cys?Ala?Glu?His?Ala?Gly?Ile?Thr?Leu?Ser

50 55 60

Asp?Ala?Asp?Tyr?Glu?Arg?Tyr?Arg?Ala?Gly?Met?Phe?Ala?Arg?Val?His

65 70 75 80

Glu?Leu?Phe?Asp?Glu?Ser?Leu?Val?Pro?Asn?Pro?Gly?Val?Thr?Glu?Leu

85 90 95

Leu?Thr?Glu?Leu?Lys?Ala?Leu?Glu?Ile?Pro?Met?Leu?Val?Thr?Thr?Asn

100 105 110

Thr?Glu?Arg?Asp?Leu?Ala?Thr?Arg?Ser?Val?Ala?Ala?Val?Gly?Asn?Glu

115 120 125

Phe?Phe?Ile?Gly?Ser?Ile?Ala?Gly?Asp?Glu?Val?Pro?Thr?Ala?Lys?Pro

130 135 140

Ala?Pro?Asp?Met?Tyr?Leu?Glu?Ala?Ala?Arg?Arg?Val?Gly?Phe?Asp?Pro

145 150 155 160

Ser?Glu?Cys?Leu?Val?Phe?Glu?Asp?Ser?Tyr?Asn?Gly?Met?Leu?Gly?Ala

165 170 175

Val?Thr?Ala?Gly?Cys?Arg?Val?Ile?Gly?Leu?His?Pro?Glu?Glu?Val?Gln

180 185 190

Ala?Pro?Glu?Gly?Val?Val?Pro?Leu?Arg?Ser?Leu?His?Gly?Lys?Asn?Ser

195 200 205

Phe?Glu?Gly?Val?Thr?Ala?Glu?Met?Val?Thr?Ala?Trp?Tyr?His?Gln?Ile

210 215 220

Glu?Pro?Ala?Gly?Val?Ala?Lys

225 230

<210>639

<211>531

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(508)

<223>RXN02461

<400>639

agaaaatctc?aaggcaaaaa?acaagccacc?ccaatctgtg?cgacaatcaa?accacagact?60

acgactatta?tgtcacgaag?aaaccaaaga?aagggaaata?atg?cgc?gga?cta?att 115

Met?Arg?Gly?Leu?Ile

1 5

gtt?gac?tac?gct?gga?gta?cta?gac?gga?acc?gat?gag?gac?cag?cgt?cgc 163

Val?Asp?Tyr?Ala?Gly?Val?Leu?Asp?Gly?Thr?Asp?Glu?Asp?Gln?Arg?Arg

10 15 20

tgg?cgc?aac?ctg?ctc?gcc?gca?gca?aag?aaa?aat?ggc?gtc?gga?acc?gtg 211

Trp?Arg?Asn?Leu?Leu?Ala?Ala?Ala?Lys?Lys?Asn?Gly?Val?Gly?Thr?Val

25 30 35

atc?ctc?agc?aac?gat?cca?ggt?ggg?ctc?ggc?gca?gcg?ccg?atc?cgg?gaa 259

Ile?Leu?Ser?Asn?Asp?Pro?Gly?Gly?Leu?Gly?Ala?Ala?Pro?Ile?Arg?Glu

40 45 50

ctc?gaa?aca?aac?ggg?gta?gtc?gat?aag?gtg?ctg?ctg?tcg?gga?gaa?ctt 307

Leu?Glu?Thr?Asn?Gly?Val?Val?Asp?Lys?Val?Leu?Leu?Ser?Gly?Glu?Leu

55 60 65

ggc?gtc?gaa?aag?cca?gag?gaa?gca?gct?ttc?cag?gcc?gcc?gca?gac?gcc 355

Gly?Val?Glu?Lys?Pro?Glu?Glu?Ala?Ala?Phe?Gln?Ala?Ala?Ala?Asp?Ala

70 75 80 85

atc?gac?ctg?ccc?atg?cgt?gac?tgc?gtg?ctt?gtc?gac?gac?tcg?atc?ctc 403

Ile?Asp?Leu?Pro?Met?Arg?Asp?Cys?Val?Leu?Val?Asp?Asp?Ser?Ile?Leu

90 95 100

aac?gtg?cgc?ggc?gcc?gtc?gaa?gcc?gga?ctc?gta?ggc?gtc?tac?tac?cag 451

Asn?Val?Arg?Gly?Ala?Val?Glu?Ala?Gly?Leu?Val?Gly?Val?Tyr?Tyr?Gln

105 110 115

caa?ttt?gac?cgt?gca?gtc?gtc?gaa?atc?gtc?gga?ctg?ttc?ggg?cta?gaa 499

Gln?Phe?Asp?Arg?Ala?Val?Val?Glu?Ile?Val?Gly?Leu?Phe?Gly?Leu?Glu

120 125 130

gga?gaa?ttc?taatcttgcg?cgtctacatc?cca 531

Gly?Glu?Phe

135

<210>640

<211>136

<212>PRT

＜213〉Corynebacterium glutamicum

<400>640

Met?Arg?Gly?Leu?Ile?Val?Asp?Tyr?Ala?Gly?Val?Leu?Asp?Gly?Thr?Asp

1 5 10 15

Glu?Asp?Gln?Arg?Arg?Trp?Arg?Asn?Leu?Leu?Ala?Ala?Ala?Lys?Lys?Asn

20 25 30

Gly?Val?Gly?Thr?Val?Ile?Leu?Ser?Asn?Asp?Pro?Gly?Gly?Leu?Gly?Ala

35 40 45

Ala?Pro?Ile?Arg?Glu?Leu?Glu?Thr?Asn?Gly?Val?Val?Asp?Lys?Val?Leu

50 55 60

Leu?Ser?Gly?Glu?Leu?Gly?Val?Glu?Lys?Pro?Glu?Glu?Ala?Ala?Phe?Gln

65 70 75 80

Ala?Ala?Ala?Asp?Ala?Ile?Asp?Leu?Pro?Met?Arg?Asp?Cys?Val?Leu?Val

85 90 95

Asp?Asp?Ser?Ile?Leu?Asn?Val?Arg?Gly?Ala?Val?Glu?Ala?Gly?Leu?Val

100 105 110

Gly?Val?Tyr?Tyr?Gln?Gln?Phe?Asp?Arg?Ala?Val?Val?Glu?Ile?Val?Gly

115 120 125

Leu?Phe?Gly?Leu?Glu?Gly?Glu?Phe

130 135

<210>641

<211>1662

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..?(1639)

<223>RXN01744

<400>641

tcttattggt?tcttcgtttt?gtatcgataa?atacaatcgg?tttcctggct?taataaggct?60

gttcctgtca?acctgcaatg?gaagaggaag?tgtacctagc?gtg?gat?gtc?gtc?gac 115

Val?Asp?Val?Val?Asp

1 5

atc?gca?cgg?tgg?caa?ttc?gga?att?acc?acc?gtc?tat?cac?ttc?att?ttt 163

Ile?Ala?Arg?Trp?Gln?Phe?Gly?Ile?Thr?Thr?Val?Tyr?His?Phe?Ile?Phe

10 15 20

gtc?cca?ctg?acc?att?ggc?tta?gcg?ccg?ctg?gtc?gca?atc?atg?caa?acg 211

Val?Pro?Leu?Thr?Ile?Gly?Leu?Ala?Pro?Leu?Val?Ala?Ile?Met?Gln?Thr

25 30 35

ttt?tgg?caa?gtt?acc?ggc?aaa?gag?cac?tgg?tat?cgg?gcc?aca?aga?ttt 259

Phe?Trp?Gln?Val?Thr?Gly?Lys?Glu?His?Trp?Tyr?Arg?Ala?Thr?Arg?Phe

40 45 50

ttt?ggc?act?gtg?ctg?ctc?atc?aac?ttc?gcg?gtt?ggt?gta?gca?acg?ggc 307

Phe?Gly?Thr?Val?Leu?Leu?Ile?Asn?Phe?Ala?Val?Gly?Val?Ala?Thr?Gly

55 60 65

att?gtg?cag?gag?ttc?cag?ttc?ggt?atg?aac?tgg?tcg?gaa?tat?tcg?cgt 355

Ile?Val?Gln?Glu?Phe?Gln?Phe?Gly?Met?Asn?Trp?Ser?Glu?Tyr?Ser?Arg

70 75 80 85

ttc?gtc?ggt?gat?gtt?ttc?ggc?gga?ccg?ctg?gct?ttg?gag?ggt?ctt?atc 403

Phe?Val?Gly?Asp?Val?Phe?Gly?Gly?Pro?Leu?Ala?Leu?Glu?Gly?Leu?Ile

90 95 100

gcg?ttc?ttc?ctt?gag?tct?gta?ttc?ctg?gga?ctg?tgg?att?ttc?gga?tgg 451

Ala?Phe?Phe?Leu?Glu?Ser?Val?Phe?Leu?Gly?Leu?Trp?Ile?Phe?Gly?Trp

105 110 115

ggg?aag?att?cct?ggt?tgg?ttg?cac?act?gca?tcc?att?tgg?atc?gtt?gct 499

Gly?Lys?Ile?Pro?Gly?Trp?Leu?His?Thr?Ala?Ser?Ile?Trp?Ile?Val?Ala

120 125 130

att?gcg?acg?aat?att?tct?gcc?tat?ttc?atc?atc?gtg?gcc?aac?tcg?ttt 547

Ile?Ala?Thr?Asn?Ile?Ser?Ala?Tyr?Phe?Ile?Ile?Val?Ala?Asn?Ser?Phe

135 140 145

atg?cag?cat?ccg?gtg?ggt?gct?gag?tat?aac?cct?gag?act?ggt?cgt?gcg 595

Met?Gln?His?Pro?Val?Gly?Ala?Glu?Tyr?Asn?Pro?Glu?Thr?Gly?Arg?Ala

150 155 160 165

gag?ctt?act?gat?ttt?tgg?gct?ctt?ctc?aca?aac?tcc?acc?gcg?ctg?gct 643

Glu?Leu?Thr?Asp?Phe?Trp?Ala?Leu?Leu?Thr?Asn?Ser?Thr?Ala?Leu?Ala

170 175 180

gcg?ttc?ccg?cat?gct?gtt?gcc?ggt?ggt?ttt?tta?aca?gct?gga?act?ttc 691

Ala?Phe?Pro?His?Ala?Val?Ala?Gly?Gly?Phe?Leu?Thr?Ala?Gly?Thr?Phe

185 190 195

gtt?ctc?gga?att?tcg?ggt?tgg?tgg?att?att?cgt?gcg?cac?cgt?cag?gcc 739

Val?Leu?Gly?Ile?Ser?Gly?Trp?Trp?Ile?Ile?Arg?Ala?His?Arg?Gln?Ala

200 205 210

aag?aag?gct?gag?tcg?gaa?atc?gag?tcg?aag?cat?tcg?atg?cac?agg?ccc 787

Lys?Lys?Ala?Glu?Ser?Glu?Ile?Glu?Ser?Lys?His?Ser?Met?His?Arg?Pro

215 220 225

gcg?ttg?tgg?gtt?ggt?tgg?tgg?acc?aca?gtt?gtc?tct?tcc?gtg?gcg?ctg 835

Ala?Leu?Trp?Val?Gly?Trp?Trp?Thr?Thr?Val?Val?Ser?Ser?Val?Ala?Leu

230 235 240 245

ttc?atc?act?ggc?gat?atc?cag?gcg?aag?ctc?atg?ttc?gtg?caa?cag?cca 883

Phe?Ile?Thr?Gly?Asp?Ile?Gln?Ala?Lys?Leu?Met?Phe?Val?Gln?Gln?Pro

250 255 260

atg?aag?atg?gcg?tcg?gcg?gaa?tcc?ttg?tgt?gaa?acc?gcc?aca?gat?cca 931

Met?Lys?Met?Ala?Ser?Ala?Glu?Ser?Leu?Cys?Glu?Thr?Ala?Thr?Asp?Pro

265 270 275

aac?ttc?tcc?att?ctg?aca?att?ggt?acg?cac?aac?aac?tgc?gat?acg?gta 979

Asn?Phe?Ser?Ile?Leu?Thr?Ile?Gly?Thr?His?Asn?Asn?Cys?Asp?Thr?Val

280 285 290

acc?cac?ctg?atc?gat?gtt?ccg?ttt?gtg?ctt?cca?ttc?ttg?gct?gaa?gga 1027

Thr?His?Leu?Ile?Asp?Val?Pro?Phe?Val?Leu?Pro?Phe?Leu?Ala?Glu?Gly

295 300 305

aaa?ttc?acc?ggt?gtg?act?ttg?cag?ggt?gta?aac?cag?ctc?caa?gct?gca 1075

Lys?Phe?Thr?Gly?Val?Thr?Leu?Gln?Gly?Val?Asn?Gln?Leu?Gln?Ala?Ala

310 315 320 325

gcg?gag?caa?gca?tac?ggt?cct?ggc?aac?tac?tcc?cct?aac?ttg?ttt?gtc 1123

Ala?Glu?Gln?Ala?Tyr?Gly?Pro?Gly?Asn?Tyr?Ser?Pro?Asn?Leu?Phe?Val

330 335 340

acc?tac?tgg?tca?ttc?cgc?gca?atg?atc?ggc?ctg?atg?ctt?ggt?tct?ttg 1171

Thr?Tyr?Trp?Ser?Phe?Arg?Ala?Met?Ile?Gly?Leu?Met?Leu?Gly?Ser?Leu

345 350 355

gct?atc?gct?gcg?att?gcg?tgg?ctg?ttg?ctg?cgt?aag?aag?cgc?aca?cca 1219

Ala?Ile?Ala?Ala?Ile?Ala?Trp?Leu?Leu?Leu?Arg?Lys?Lys?Arg?Thr?Pro

360 365 370

act?gga?aag?att?gct?cgt?ctg?ttc?cag?atc?ggc?agc?ctc?att?gct?atc 1267

Thr?Gly?Lys?Ile?Ala?Arg?Leu?Phe?Gln?Ile?Gly?Ser?Leu?Ile?Ala?Ile

375 380 385

ccg?ttc?cca?ttc?ttg?gcc?aac?tct?gct?ggt?tgg?atc?ttc?acc?gag?atg 1315

Pro?Phe?Pro?Phe?Leu?Ala?Asn?Ser?Ala?Gly?Trp?Ile?Phe?Thr?Glu?Met

390 395 400 405

ggc?cgc?cag?cct?tgg?gtg?gtg?cac?ccg?aac?cct?gaa?tct?gcc?ggc?gat 1363

Gly?Arg?Gln?Pro?Trp?Val?Val?His?Pro?Asn?Pro?Glu?Ser?Ala?Gly?Asp

410 415 420

gcc?cga?aca?gag?atg?atc?cgg?atg?act?gtt?gat?atg?ggt?gta?tct?gat 1411

Ala?Arg?Thr?Glu?Met?Ile?Arg?Met?Thr?Val?Asp?Met?Gly?Val?Ser?Asp

425 430 435

cat?gcg?cca?tgg?caa?gtc?tgg?ctg?act?ctc?att?ggc?ttc?acg?att?ctc 1459

His?Ala?Pro?Trp?Gln?Val?Trp?Leu?Thr?Leu?Ile?Gly?Phe?Thr?Ile?Leu

440 445 450

tat?ctc?att?ttg?ttc?gtg?gtg?tgg?gtg?tgg?ctg?att?cgc?cgc?gca?gtt 1507

Tyr?Leu?Ile?Leu?Phe?Val?Val?Trp?Val?Trp?Leu?Ile?Arg?Arg?Ala?Val

455 460 465

ctg?atc?gga?cca?cca?gag?gaa?ggc?gct?cca?tcc?gtg?gag?gca?aag?act 1555

Leu?Ile?Gly?Pro?Pro?Glu?Glu?Gly?Ala?Pro?Ser?Val?Glu?Ala?Lys?Thr

470 475 480 485

gga?ccg?gca?acc?ccg?att?ggt?tca?gat?atg?ccc?atg?aca?ccg?ctg?caa 1603

Gly?Pro?Ala?Thr?Pro?Ile?Gly?Ser?Asp?Met?Pro?Met?Thr?Pro?Leu?Gln

490 495 500

ttt?act?gcc?gct?gcc?cca?acc?aca?ggt?gaa?aag?gaa?taaccatgga 1649

Phe?Thr?Ala?Ala?Ala?Pro?Thr?Thr?Gly?Glu?Lys?Glu

505 510

tctcaatacc?ttt 1662

<210>642

<211>513

<212>PRT

＜213〉Corynebacterium glutamicum

<400>642

Val?Asp?Val?Val?Asp?Ile?Ala?Arg?Trp?Gln?Phe?Gly?Ile?Thr?Thr?Val

1 5 10 15

Tyr?His?Phe?Ile?Phe?Val?Pro?Leu?Thr?Ile?Gly?Leu?Ala?Pro?Leu?Val

20 25 30

Ala?Ile?Met?Gln?Thr?Phe?Trp?Gln?Val?Thr?Gly?Lys?Glu?His?Trp?Tyr

35 40 45

Arg?Ala?Thr?Arg?Phe?Phe?Gly?Thr?Val?Leu?Leu?Ile?Asn?Phe?Ala?Val

50 55 60

Gly?Val?Ala?Thr?Gly?Ile?Val?Gln?Glu?Phe?Gln?Phe?Gly?Met?Asn?Trp

65 70 75 80

Ser?Glu?Tyr?Ser?Arg?Phe?Val?Gly?Asp?Val?Phe?Gly?Gly?Pro?Leu?Ala

85 90 95

Leu?Glu?Gly?Leu?Ile?Ala?Phe?Phe?Leu?Glu?Ser?Val?Phe?Leu?Gly?Leu

100 105 110

Trp?Ile?Phe?Gly?Trp?Gly?Lys?Ile?Pro?Gly?Trp?Leu?His?Thr?Ala?Ser

115 120 125

Ile?Trp?Ile?Val?Ala?Ile?Ala?Thr?Asn?Ile?Ser?Ala?Tyr?Phe?Ile?Ile

130 135 140

Val?Ala?Asn?Ser?Phe?Met?Gln?His?Pro?Val?Gly?Ala?Glu?Tyr?Asn?Pro

145 150 155 160

Glu?Thr?Gly?Arg?Ala?Glu?Leu?Thr?Asp?Phe?Trp?Ala?Leu?Leu?Thr?Asn

165 170 175

Ser?Thr?Ala?Leu?Ala?Ala?Phe?Pro?His?Ala?Val?Ala?Gly?Gly?Phe?Leu

180 185 190

Thr?Ala?Gly?Thr?Phe?Val?Leu?Gly?Ile?Ser?Gly?Trp?Trp?Ile?Ile?Arg

195 200 205

Ala?His?Arg?Gln?Ala?Lys?Lys?Ala?Glu?Ser?Glu?Ile?Glu?Ser?Lys?His

210 215 220

Ser?Met?His?Arg?Pro?Ala?Leu?Trp?Val?Gly?Trp?Trp?Thr?Thr?Val?Val

225 230 235 240

Ser?Ser?Val?Ala?Leu?Phe?Ile?Thr?Gly?Asp?Ile?Gln?Ala?Lys?Leu?Met

245 250 255

Phe?Val?Gln?Gln?Pro?Met?Lys?Met?Ala?Ser?Ala?Glu?Ser?Leu?Cys?Glu

260 265 270

Thr?Ala?Thr?Asp?Pro?Asn?Phe?Ser?Ile?Leu?Thr?Ile?Gly?Thr?His?Asn

275 280 285

Asn?Cys?Asp?Thr?Val?Thr?His?Leu?Ile?Asp?Val?Pro?Phe?Val?Leu?Pro

290 295 300

Phe?Leu?Ala?Glu?Gly?Lys?Phe?Thr?Gly?Val?Thr?Leu?Gln?Gly?Val?Asn

305 310 315 320

Gln?Leu?Gln?Ala?Ala?Ala?Glu?Gln?Ala?Tyr?Gly?Pro?Gly?Asn?Tyr?Ser

325 330 335

Pro?Asn?Leu?Phe?Val?Thr?Tyr?Trp?Ser?Phe?Arg?Ala?Met?Ile?Gly?Leu

340 345 350

Met?Leu?Gly?Ser?Leu?Ala?Ile?Ala?Ala?Ile?Ala?Trp?Leu?Leu?Leu?Arg

355 360 365

Lys?Lys?Arg?Thr?Pro?Thr?Gly?Lys?Ile?Ala?Arg?Leu?Phe?Gln?Ile?Gly

370 375 380

Ser?Leu?Ile?Ala?Ile?Pro?Phe?Pro?Phe?Leu?Ala?Asn?Ser?Ala?Gly?Trp

385 390 395 400

Ile?Phe?Thr?Glu?Met?Gly?Arg?Gln?Pro?Trp?Val?Val?His?Pro?Asn?Pro

405 410 415

Glu?Ser?Ala?Gly?Asp?Ala?Arg?Thr?Glu?Met?Ile?Arg?Met?Thr?Val?Asp

420 425 430

Met?Gly?Val?Ser?Asp?His?Ala?Pro?Trp?Gln?Val?Trp?Leu?Thr?Leu?Ile

435 440 445

Gly?Phe?Thr?Ile?Leu?Tyr?Leu?Ile?Leu?Phe?Val?Val?Trp?Val?Trp?Leu

450 455 460

Ile?Arg?Arg?Ala?Val?Leu?Ile?Gly?Pro?Pro?Glu?Glu?Gly?Ala?Pro?Ser

465 470 475 480

Val?Glu?Ala?Lys?Thr?Gly?Pro?Ala?Thr?Pro?Ile?Gly?Ser?Asp?Met?Pro

485 490 495

Met?Thr?Pro?Leu?Gln?Phe?Thr?Ala?Ala?Ala?Pro?Thr?Thr?Gly?Glu?Lys

500 505 510

Glu

<210>643

<211>238

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(238)

<223>FRXA00055

<400>643

tcttattggt?tcttcgtttt?gtatcgataa?atacaatcgg?tttcctggct?taataaggct?60

gttcctgtca?acctgcaatg?gaagaggaag?tgtacctagc?gtg?gat?gtc?gtc?gac 115

Val?Asp?Val?Val?Asp

1 5

atc?gca?cgg?tgg?caa?ttc?gga?att?acc?acc?gtc?tat?cacttc?att?ttt 163

Ile?Ala?Arg?Trp?Gln?Phe?Gly?Ile?Thr?Thr?Val?Tyr?His?Phe?Ile?Phe

10 15 20

gtc?cca?ctg?acc?att?ggc?tta?gca?ccg?ctg?gtc?gcg?atc?atg?caa?acg 211

Val?Pro?Leu?Thr?Ile?Gly?Leu?Ala?Pro?Leu?Val?Ala?Ile?Met?Gln?Thr

25 30 35

ttt?tgg?caa?gtt?acc?ggc?aaa?gag?cac 238

Phe?Trp?Gln?Val?Thr?Gly?Lys?Glu?His

40 45

<210>644

<211>46

<212>PRT

＜213〉Corynebacterium glutamicum

<400>644

Val?Asp?Val?Val?Asp?Ile?Ala?Arg?Trp?Gln?Phe?Gly?Ile?Thr?Thr?Val

1 5 10 15

Tyr?His?Phe?Ile?Phe?Val?Pro?Leu?Thr?Ile?Gly?Leu?Ala?Pro?Leu?Val

20 25 30

Ala?Ile?Met?Gln?Thr?Phe?Trp?Gln?Val?Thr?Gly?Lys?Glu?His

35 40 45

<210>645

<211>1325

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(1302)

<223>FRXA01744

<400>645

tgg?tcg?gaa?tat?tcg?cgt?ttc?gtc?ggt?gat?gtt?ttc?ggc?gga?ccg?ctg 48

Trp?Ser?Glu?Tyr?Ser?Arg?Phe?Val?Gly?Asp?Val?Phe?Gly?Gly?Pro?Leu

1 5 10 15

gct?ttg?gag?ggt?ctt?atc?gcg?ttc?ttc?ctt?gag?tct?gta?ttc?ctg?gga 96

Ala?Leu?Glu?Gly?Leu?Ile?Ala?Phe?Phe?Leu?Glu?Ser?Val?Phe?Leu?Gly

20 25 30

ctg?tgg?att?ttc?gga?tgg?ggg?aag?att?cct?ggt?tgg?ttg?cac?act?gca 144

Leu?Trp?Ile?Phe?Gly?Trp?Gly?Lys?Ile?Pro?Gly?Trp?Leu?His?Thr?Ala

35 40 45

tcc?att?tgg?atc?gtt?gct?att?gcg?acg?aat?att?tct?gcc?tat?ttc?atc 192

Ser?Ile?Trp?Ile?Val?Ala?Ile?Ala?Thr?Asn?Ile?Ser?Ala?Tyr?Phe?Ile

50 55 60

atc?gtg?gcc?aac?tcg?ttt?atg?cag?cat?ccg?gtg?ggt?gct?gag?tat?aac 240

Ile?Val?Ala?Asn?Ser?Phe?Met?Gln?His?Pro?Val?Gly?Ala?Glu?Tyr?Asn

65 70 75 80

cct?gag?act?ggt?cgt?gcg?gag?ctt?act?gat?ttt?tgg?gct?ctt?ctc?aca 288

Pro?Glu?Thr?Gly?Arg?Ala?Glu?Leu?Thr?Asp?Phe?Trp?Ala?Leu?Leu?Thr

85 90 95

aac?tcc?acc?gcg?ctg?gct?gcg?ttc?ccg?cat?gct?gtt?gcc?ggt?ggt?ttt 336

Asn?Ser?Thr?Ala?Leu?Ala?Ala?Phe?Pro?His?Ala?Val?Ala?Gly?Gly?Phe

100 105 110

tta?aca?gct?gga?act?ttc?gtt?ctc?gga?att?tcg?ggt?tgg?tgg?att?att 384

Leu?Thr?Ala?Gly?Thr?Phe?Val?Leu?Gly?Ile?Ser?Gly?Trp?Trp?Ile?Ile

115 120 125

cgt?gcg?cac?cgt?cag?gcc?aag?aag?gct?gag?tcg?gaa?atc?gag?tcg?aag 432

Arg?Ala?His?Arg?Gln?Ala?Lys?Lys?Ala?Glu?Ser?Glu?Ile?Glu?Ser?Lys

130 135 140

cat?tcg?atg?cac?agg?ccc?gcg?ttg?tgg?gtt?ggt?tgg?tgg?acc?aca?gtt 480

His?Ser?Met?His?Arg?Pro?Ala?Leu?Trp?Val?Gly?Trp?Trp?Thr?Thr?Val

145 150 155 160

gtc?tct?tcc?gtg?gcg?ctg?ttc?atc?act?ggc?gat?atc?cag?gcg?aag?ctc 528

Val?Ser?Ser?Val?Ala?Leu?Phe?Ile?Thr?Gly?Asp?Ile?Gln?Ala?Lys?Leu

165 170 175

atg?ttc?gtg?caa?cag?cca?atg?aag?atg?gcg?tcg?gcg?gaa?tcc?ttg?tgt 576

Met?Phe?Val?Gln?Gln?Pro?Met?Lys?Met?Ala?Ser?Ala?Glu?Ser?Leu?Cys

180 185 190

gaa?acc?gcc?aca?gat?cca?aac?ttc?tcc?att?ctg?aca?att?ggt?acg?cac 624

Glu?Thr?Ala?Thr?Asp?Pro?Asn?Phe?Ser?Ile?Leu?Thr?Ile?Gly?Thr?His

195 200 205

aac?aac?tgc?gat?acg?gta?acc?cac?ctg?atc?gat?gtt?ccg?ttt?gtg?ctt 672

Asn?Asn?Cys?Asp?Thr?Val?Thr?His?Leu?Ile?Asp?Val?Pro?Phe?Val?Leu

210 215 220

cca?ttc?ttg?gct?gaa?gga?aaa?ttc?acc?ggt?gtg?act?ttg?cag?ggt?gta 720

Pro?Phe?Leu?Ala?Glu?Gly?Lys?Phe?Thr?Gly?Val?Thr?Leu?Gln?Gly?Val

225 230 235 240

aac?cag?ctc?caa?gct?gca?gcg?gag?caa?gca?tac?ggt?cct?ggc?aac?tac 768

Asn?Gln?Leu?Gln?Ala?Ala?Ala?Glu?Gln?Ala?Tyr?Gly?Pro?Gly?Asn?Tyr

245 250 255

tcc?cct?aac?ttg?ttt?gtc?acc?tac?tgg?tca?ttc?cgc?gca?atg?atc?ggc 816

Ser?Pro?Asn?Leu?Phe?Val?Thr?Tyr?Trp?Ser?Phe?Arg?Ala?Met?Ile?Gly

260 265 270

ctg?atg?ctt?ggt?tct?ttg?gct?atc?gct?gcg?att?gcg?tgg?ctg?ttg?ctg 864

Leu?Met?Leu?Gly?Ser?Leu?Ala?Ile?Ala?Ala?Ile?Ala?Trp?Leu?Leu?Leu

275 280 285

cgt?aag?aag?cgc?aca?cca?act?gga?aag?att?gct?cgt?ctg?ttc?cag?atc 912

Arg?Lys?Lys?Arg?Thr?Pro?Thr?Gly?Lys?Ile?Ala?Arg?Leu?Phe?Gln?Ile

290 295 300

ggc?agc?ctc?att?gct?atc?ccg?ttc?cca?ttc?ttg?gcc?aac?tct?gct?ggt 960

Gly?Ser?Leu?Ile?Ala?Ile?Pro?Phe?Pro?Phe?Leu?Ala?Asn?Ser?Ala?Gly

305 310 315 320

tgg?atc?ttc?acc?gag?atg?ggc?cgc?cag?cct?tgg?gtg?gtg?cac?ccg?aac 1008

Trp?Ile?Phe?Thr?Glu?Met?Gly?Arg?Gln?Pro?Trp?Val?Val?His?Pro?Asn

325 330 335

cct?gaa?tct?gcc?ggc?gat?gcc?cga?aca?gag?atg?atc?cgg?atg?act?gtt 1056

Pro?Glu?Ser?Ala?Gly?Asp?Ala?Arg?Thr?Glu?Met?Ile?Arg?Met?Thr?Val

340 345 350

gat?atg?ggt?gta?tct?gat?cat?gcg?cca?tgg?caa?gtc?tgg?ctg?act?ctc 1104

Asp?Met?Gly?Val?Ser?Asp?His?Ala?Pro?Trp?Gln?Val?Trp?Leu?Thr?Leu

355 360 365

att?ggc?ttc?acg?att?ctc?tat?ctc?att?ttg?ttc?gtg?gtg?tgg?gtg?tgg 1152

Ile?Gly?Phe?Thr?Ile?Leu?Tyr?Leu?Ile?Leu?Phe?Val?Val?Trp?Val?Trp

370 375 380

ctg?att?cgc?cgc?gca?gtt?ctg?atc?gga?cca?cca?gag?gaa?ggc?gct?cca 1200

Leu?Ile?Arg?Arg?Ala?Val?Leu?Ile?Gly?Pro?Pro?Glu?Glu?Gly?Ala?Pro

385 390 395 400

tcc?gtg?gag?gca?aag?act?gga?ccg?gca?acc?ccg?att?ggt?tca?gat?atg 1248

Ser?Val?Glu?Ala?Lys?Thr?Gly?Pro?Ala?Thr?Pro?Ile?Gly?Ser?Asp?Met

405 410 415

ccc?atg?aca?ccg?ctg?caa?ttt?act?gcc?gct?gcc?cca?acc?aca?ggt?gaa 1296

Pro?Met?Thr?Pro?Leu?Gln?Phe?Thr?Ala?Ala?Ala?Pro?Thr?Thr?Gly?Glu

420 425 430

aag?gaa?taaccatgga?tctcaatacc?ttt 1325

Lys?Glu

<210>646

<211>434

<212>PRT

＜213〉Corynebacterium glutamicum

<400>646

Trp?Ser?Glu?Tyr?Ser?Arg?Phe?Val?Gly?Asp?Val?Phe?Gly?Gly?Pro?Leu

1 5 10 15

Ala?Leu?Glu?Gly?Leu?Ile?Ala?Phe?Phe?Leu?Glu?Ser?Val?Phe?Leu?Gly

20 25 30

Leu?Trp?Ile?Phe?Gly?Trp?Gly?Lys?Ile?Pro?Gly?Trp?Leu?His?Thr?Ala

35 40 45

Ser?Ile?Trp?Ile?Val?Ala?Ile?Ala?Thr?Asn?Ile?Ser?Ala?Tyr?Phe?Ile

50 55 60

Ile?Val?Ala?Asn?Ser?Phe?Met?Gln?His?Pro?Val?Gly?Ala?Glu?Tyr?Asn

65 70 75 80

Pro?Glu?Thr?Gly?Arg?Ala?Glu?Leu?Thr?Asp?Phe?Trp?Ala?Leu?Leu?Thr

85 90 95

Asn?Ser?Thr?Ala?Leu?Ala?Ala?Phe?Pro?His?Ala?Val?Ala?Gly?Gly?Phe

100 105 110

Leu?Thr?Ala?Gly?Thr?Phe?Val?Leu?Gly?Ile?Ser?Gly?Trp?Trp?Ile?Ile

115 120 125

Arg?Ala?His?Arg?Gln?Ala?Lys?Lys?Ala?Glu?Ser?Glu?Ile?Glu?Ser?Lys

130 135 140

His?Ser?Met?His?Arg?Pro?Ala?Leu?Trp?Val?Gly?Trp?Trp?Thr?Thr?Val

145 150 155 160

Val?Ser?Ser?Val?Ala?Leu?Phe?Ile?Thr?Gly?Asp?Ile?Gln?Ala?Lys?Leu

165 170 175

Met?Phe?Val?Gln?Gln?Pro?Met?Lys?Met?Ala?Ser?Ala?Glu?Ser?Leu?Cys

180 185 190

Glu?Thr?Ala?Thr?Asp?Pro?Asn?Phe?Ser?Ile?Leu?Thr?Ile?Gly?Thr?His

195 200 205

Asn?Asn?Cys?Asp?Thr?Val?Thr?His?Leu?Ile?Asp?Val?Pro?Phe?Val?Leu

210 215 220

Pro?Phe?Leu?Ala?Glu?Gly?Lys?Phe?Thr?Gly?Val?Thr?Leu?Gln?Gly?Val

225 230 235 240

Asn?Gln?Leu?Gln?Ala?Ala?Ala?Glu?Gln?Ala?Tyr?Gly?Pro?Gly?Asn?Tyr

245 250 255

Ser?Pro?Asn?Leu?Phe?Val?Thr?Tyr?Trp?Ser?Phe?Arg?Ala?Met?Ile?Gly

260 265 270

Leu?Met?Leu?Gly?Ser?Leu?Ala?Ile?Ala?Ala?Ile?Ala?Trp?Leu?Leu?Leu

275 280 285

Arg?Lys?Lys?Arg?Thr?Pro?Thr?Gly?Lys?Ile?Ala?Arg?Leu?Phe?Gln?Ile

290 295 300

Gly?Ser?Leu?Ile?Ala?Ile?Pro?Phe?Pro?Phe?Leu?Ala?Asn?Ser?Ala?Gly

305 310 315 320

Trp?Ile?Phe?Thr?Glu?Met?Gly?Arg?Gln?Pro?Trp?Val?Val?His?Pro?Asn

325 330 335

Pro?Glu?Ser?Ala?Gly?Asp?Ala?Arg?Thr?Glu?Met?Ile?Arg?Met?Thr?Val

340 345 350

Asp?Met?Gly?Val?Ser?Asp?His?Ala?Pro?Trp?Gln?Val?Trp?Leu?Thr?Leu

355 360 365

Ile?Gly?Phe?Thr?Ile?Leu?Tyr?Leu?Ile?Leu?Phe?Val?Val?Trp?Val?Trp

370 375 380

Leu?Ile?Arg?Arg?Ala?Val?Leu?Ile?Gly?Pro?Pro?Glu?Glu?Gly?Ala?Prc

385 390 395 400

Ser?Val?Glu?Ala?Lys?Thr?Gly?Pro?Ala?Thr?Pro?Ile?Gly?Ser?Asp?Met

405 410 415

Pro?Met?Thr?Pro?Leu?Gln?Phe?Thr?Ala?Ala?Ala?Pro?Thr?Thr?Gly?Glu

420 425 430

Lys?Glu

<210>647

<211>307

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(307)

<223>RXA00379

<400>647

cgtgctggat?aaacagcacc?gccccgcagc?agtgttcttg?cgcgaagtca?cctccaaaga?60

tgtgttggat?gttgcgttgc?cattggtaga?tgaggcctaa?atg?tct?gag?att?gtg 115

Met?Ser?Glu?Ile?Val

1 5

gta?gcc?caa?agc?atc?ggc?cag?cag?ttt?gct?gac?gtc?gca?gct?tcc?ggg 163

Val?Ala?Gln?Ser?Ile?Gly?Gln?Gln?Phe?Ala?Asp?Val?Ala?Ala?Ser?Gly

10 15 20

cca?ctg?ttc?ctt?ggc?atc?ctt?gcc?gca?gcg?ctc?gca?ggt?ctg?gtg?tct 211

Pro?Leu?Phe?Leu?Gly?Ile?Leu?Ala?Ala?Ala?Leu?Ala?Gly?Leu?Val?Ser

25 30 35

ttt?gcc?agc?ccg?tgt?gtt?gtg?ccg?ttg?gtg?cca?gga?tat?att?tcc?tac 259

Phe?Ala?Ser?Pro?Cys?Val?Val?Pro?Leu?Val?Pro?Gly?Tyr?Ile?Ser?Tyr

40 45 50

ctc?gcc?ggc?gtg?gtc?ggt?ggg?gaa?gtg?gaa?tac?agc?gct?cat?gcc?acc 307

Leu?Ala?Gly?Val?Val?Gly?Gly?Glu?Val?Glu?Tyr?Ser?Ala?His?Ala?Thr

55 60 65

<210>648

<211>69

<212>PRT

＜213〉Corynebacterium glutamicum

<400>648

Met?Ser?Glu?Ile?Val?Val?Ala?Gln?Ser?Ile?Gly?Gln?Gln?Phe?Ala?Asp

1 5 10 15

Val?Ala?Ala?Ser?Gly?Pro?Leu?Phe?Leu?Gly?Ile?Leu?Ala?Ala?Ala?Leu

20 25 30

Ala?Gly?Leu?Val?Ser?Phe?Ala?Ser?Pro?Cys?Val?Val?Pro?Leu?Val?Pro

35 40 45

Gly?Tyr?Ile?Ser?Tyr?Leu?Ala?Gly?Val?Val?Gly?Gly?Glu?Val?Glu?Tyr

50 55 60

Ser?Ala?His?Ala?Thr

65

<210>649

<211>362

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(339)

<223>RXA00385

<400>649

ctt?ggc?gga?gtg?ttc?gct?ctc?ggt?tgg?acc?cct?tgt?ttg?ggc?ccc?acc 48

Leu?Gly?Gly?Val?Phe?Ala?Leu?Gly?Trp?Thr?Pro?Cys?Leu?Gly?Pro?Thr

1 5 10 15

ctg?gct?gcg?atc?atc?tcc?att?tct?gca?ggt?act?gaa?ggc?atg?acc?gct 96

Leu?Ala?Ala?Ile?Ile?Ser?Ile?Ser?Ala?Gly?Thr?Glu?Gly?Met?Thr?Ala

20 25 30

gcg?cgt?ggc?gtg?atc?tta?att?gtg?ggt?tac?tgc?ctc?gga?ctg?ggg?ctg 144

Ala?Arg?Gly?Val?Ile?Leu?Ile?Val?Gly?Tyr?Cys?Leu?Gly?Leu?Gly?Leu

35 40 45

ccg?ttc?ctg?ctg?atc?gcg?ttg?ggc?tcc?agc?aag?gca?ctc?acc?gga?gtc 192

Pro?Phe?Leu?Leu?Ile?Ala?Leu?Gly?Ser?Ser?Lys?Ala?Leu?Thr?Gly?Val

50 55 60

gag?tgg?ttg?cgc?aag?cat?tcc?cgc?acc?ctg?caa?att?atc?ggc?ggt?gtg 240

Glu?Trp?Leu?Arg?Lys?His?Ser?Arg?Thr?Leu?Gln?Ile?Ile?Gly?Gly?Val

65 70 75 80

ttt?ttg?atc?ttg?gtc?gga?gta?gcg?ttg?ctc?tct?ggc?tca?tgg?gca?att 288

Phe?Leu?Ile?Leu?Val?Gly?Val?Ala?Leu?Leu?Ser?Gly?Ser?Trp?Ala?Ile

85 90 95

ttt?atc?aac?tgg?gtc?cgt?cag?tgg?acc?gtt?gaa?tac?ggc?gca?aca?ctg 336

Phe?Ile?Asn?Trp?Val?Arg?Gln?Trp?Thr?Val?Glu?Tyr?Gly?Ala?Thr?Leu

100 105 ll0

ctc?tagaaaaaga?cttttagtag?gaa 362

Leu

<210>650

<211>113

<212>PRT

＜213〉Corynebacterium glutamicum

<400>650

Leu?Gly?Gly?Val?Phe?Ala?Leu?Gly?Trp?Thr?Pro?Cys?Leu?Gly?Pro?Thr

1 5 10 15

Leu?Ala?Ala?Ile?Ile?Ser?Ile?Ser?Ala?Gly?Thr?Glu?Gly?Met?Thr?Ala

20 25 30

Ala?Arg?Gly?Val?Ile?Leu?Ile?Val?Gly?Tyr?Cys?Leu?Gly?Leu?Gly?Leu

35 40 45

Pro?Phe?Leu?Leu?Ile?Ala?Leu?Gly?Ser?Ser?Lys?Ala?Leu?Thr?Gly?Val

50 55 60

Glu?Trp?Leu?Arg?Lys?His?Ser?Arg?Thr?Leu?Gln?Ile?Ile?Gly?Gly?Val

65 70 75 80

Phe?Leu?Ile?Leu?Val?Gly?Val?Ala?Leu?Leu?Ser?Gly?Ser?Trp?Ala?Ile

85 90 95

Phe?Ile?Asn?Trp?Val?Arg?Gln?Trp?Thr?Val?Glu?Tyr?Gly?Ala?Thr?Leu

100 105 110

Leu

<210>651

<211>901

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(901)

<223>RXA01743

<400>651

aggcaaagac?tggaccggca?accccgattg?gttcagatat?gcccatgaca?ccgctgcaat?60

ttactgccgc?tgccccaacc?acaggtgaaa?aggaataacc?atg?gat?ctc?aat?acc 115

Met?Asp?Leu?Asn?Thr

1 5

ttt?tgg?ttt?att?ctc?atc?gca?ttt?ttg?ttt?gcg?gga?tac?ttt?ctc?ctc 163

Phe?Trp?Phe?Ile?Leu?Ile?Ala?Phe?Leu?Phe?Ala?Gly?Tyr?Phe?Leu?Leu

10 15 20

gaa?gga?ttc?gac?ttc?ggc?gtc?gga?att?ttg?gca?ccc?atc?atc?ggt?aaa 211

Glu?Gly?Phe?Asp?Phe?Gly?Val?Gly?Ile?Leu?Ala?Pro?Ile?Ile?Gly?Lys

25 30 35

gat?tca?gcg?gct?agg?aac?aca?gtg?atc?cgt?acg?att?ggc?cct?gtc?tgg 259

Asp?Ser?Ala?Ala?Arg?Asn?Thr?Val?Ile?Arg?Thr?Ile?Gly?Pro?Val?Trp

40 45 50

gac?gga?aat?gaa?gtg?tgg?ctg?atc?gtg?gca?ggt?ggc?gct?ttg?ttt?gct 307

Asp?Gly?Asn?Glu?Val?Trp?Leu?Ile?Val?Ala?Gly?Gly?Ala?Leu?Phe?Ala

55 60 65

gcc?ttc?cct?gag?tgg?tac?gca?acg?atg?ttc?tcc?gga?atg?tat?ctg?ccg 355

Ala?Phe?Pro?Glu?Trp?Tyr?Ala?Thr?Met?Phe?Ser?Gly?Met?Tyr?Leu?Pro

70 75 80 85

ctg?ttc?ctc?gtg?ctt?gtg?tcg?ttg?atc?atg?cgc?gtg?gtg?ggc?ctt?gaa 403

Leu?Phe?Leu?Val?Leu?Val?Ser?Leu?Ile?Met?Arg?Val?Val?Gly?Leu?Glu

90 95 100

tgg?cgc?aag?aaa?gtc?gat?gat?cct?cgt?tgg?caa?aag?tgg?tct?gac?cgg 451

Trp?Arg?Lys?Lys?Val?Asp?Asp?Pro?Arg?Trp?Gln?Lys?Trp?Ser?Asp?Arg

105 110 115

gcc?atc?ttt?att?ggt?tct?tgg?act?cca?ccg?ctg?atg?tgg?gga?ttc?atc 499

Ala?Ile?Phe?Ile?Gly?Ser?Trp?Thr?Pro?Pro?Leu?Met?Trp?Gly?Phe?Ile

120 125 130

ttc?gcc?aat?att?ttg?cgt?ggc?atg?ccc?ctc?aag?gcg?gat?cac?acc?atc 547

Phe?Ala?Asn?Ile?Leu?Arg?Gly?Met?Pro?Leu?Lys?Ala?Asp?His?Thr?Ile

135 140 145

gat?gct?gcg?gca?gcc?ctt?cct?ggc?atg?gtc?aac?gtc?ttc?gcc?att?ctg 595

Asp?Ala?Ala?Ala?Ala?Leu?Pro?Gly?Met?Val?Asn?Val?Phe?Ala?Ile?Leu

150 155 160 165

ggt?gca?ctt?gcg?ttc?acc?gca?ctg?ttc?gcc?ctt?cat?ggt?ctc?gca?ttc 643

Gly?Ala?Leu?Ala?Phe?Thr?Ala?Leu?Phe?Ala?Leu?His?Gly?Leu?Ala?Phe

170 175 180

atc?cgc?ctg?aaa?act?gct?ggt?cgg?gtg?cgc?acc?gat?gcg?gcg?aag?gca 691

Ile?Arg?Leu?Lys?Thr?Ala?Gly?Arg?Val?Arg?Thr?Asp?Ala?Ala?Lys?Ala

185 190 195

gct?cca?gta?gtc?gca?ctt?ctt?gct?gcg?gtg?act?ggt?gga?cct?ttc?gtg 739

Ala?Pro?Val?Val?Ala?Leu?Leu?Ala?Ala?Val?Thr?Gly?Gly?Pro?Phe?Val

200 205 210

ttg?tgg?gct?gcc?atc?gca?tac?ggc?cgt?tcc?tgg?tcc?tgg?atc?ctc?gca 787

Leu?Trp?Ala?Ala?Ile?Ala?Tyr?Gly?Arg?Ser?Trp?Ser?Trp?Ile?Leu?Ala

215 220 225

gtg?ctg?atc?atc?gca?gcg?gtt?ctc?ggt?gga?gct?ttc?gca?ctg?atc?aaa 835

Val?Leu?Ile?Ile?Ala?Ala?Val?Leu?Gly?Gly?Ala?Phe?Ala?Leu?Ile?Lys

230 235 240 245

gac?cgc?gat?gga?tta?agc?ttc?ctg?tcc?act?tcc?gtc?gct?gtc?atc?ggt 883

Asp?Arg?Asp?Gly?Leu?Ser?Phe?Leu?Ser?Thr?Ser?Val?Ala?Val?Ile?Gly

250 255 260

gtc?gtt?gca?ctg?ctg?ttt 901

Val?Val?Ala?Leu?Leu?Phe

265

<210>652

<211>267

<212>PRT

＜213〉Corynebacterium glutamicum

<400>652

Met?Asp?Leu?Asn?Thr?Phe?Trp?Phe?Ile?Leu?Ile?Ala?Phe?Leu?Phe?Ala

1 5 10 15

Gly?Tyr?Phe?Leu?Leu?Glu?Gly?Phe?Asp?Phe?Gly?Val?Gly?Ile?Leu?Ala

20 25 30

Pro?Ile?Ile?Gly?Lys?Asp?Ser?Ala?Ala?Arg?Asn?Thr?Val?Ile?Arg?Thr

35 40 45

Ile?Gly?Pro?Val?Trp?Asp?Gly?Asn?Glu?Val?Trp?Leu?Ile?Val?Ala?Gly

50 55 60

Gly?Ala?Leu?Phe?Ala?Ala?Phe?Pro?Glu?Trp?Tyr?Ala?Thr?Met?Phe?Ser

65 70 75 80

Gly?Met?Tyr?Leu?Pro?Leu?Phe?Leu?Val?Leu?Val?Ser?Leu?Ile?Met?Arg

85 90 95

Val?Val?Gly?Leu?Glu?Trp?Arg?Lys?Lys?Val?Asp?Asp?Pro?Arg?Trp?Gln

100 105 110

Lys?Trp?Ser?Asp?Arg?Ala?Ile?Phe?Ile?Gly?Ser?Trp?Thr?Pro?Pro?Leu

115 120 125

Met?Trp?Gly?Phe?Ile?Phe?Ala?Asn?Ile?Leu?Arg?Gly?Met?Pro?Leu?Lys

130 135 140

Ala?Asp?His?Thr?Ile?Asp?Ala?Ala?Ala?Ala?Leu?Pro?Gly?Met?Val?Ash

145 150 155 160

Val?Phe?Ala?Ile?Leu?Gly?Ala?Leu?Ala?Phe?Thr?Ala?Leu?Phe?Ala?Leu

165 170 175

His?Gly?Leu?Ala?Phe?Ile?Arg?Leu?Lys?Thr?Ala?Gly?Arg?Val?Arg?Thr

180 185 190

Asp?Ala?Ala?Lys?Ala?Ala?Pro?Val?Val?Ala?Leu?Leu?Ala?Ala?Val?Thr

195 200 205

Gly?Gly?Pro?Phe?Val?Leu?Trp?Ala?Ala?Ile?Ala?Tyr?Gly?Arg?Ser?Trp

210 215 220

Ser?Trp?Ile?Leu?Ala?Val?Leu?Ile?Ile?Ala?Ala?Val?Leu?Gly?Gly?Ala

225 230 235 240

Phe?Ala?Leu?Ile?Lys?Asp?Arg?Asp?Gly?Leu?Ser?Phe?Leu?Ser?Thr?Ser

245 250 255

Val?Ala?Val?Ile?Gly?Val?Val?Ala?Leu?Leu?Phe

260 265

<210>653

<211>1779

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1756)

<223>RXN02480

<400>653

acctatgacc?gctgtggcgc?ctagggtcga?cgggcacgtc?gcccctcaga?ggcccgagcc?60

gacaggccat?gcacgcaagg?gcagcaaagc?atggttaatg?atg?acc?acc?acc?gac 115

Met?Thr?Thr?Thr?Asp

1 5

cac?aag?cag?ctg?ggc?att?atg?tac?atc?att?atg?tcc?ttc?agc?ttc?ttc 163

His?Lys?Gln?Leu?Gly?Ile?Met?Tyr?Ile?Ile?Met?Ser?Phe?Ser?Phe?Phe

10 15 20

ttc?ctc?ggt?ggc?ttg?atg?gcc?ctg?ctt?atc?cga?gcg?gag?ctt?ttc?acc 211

Phe?Leu?Gly?Gly?Leu?Met?Ala?Leu?Leu?Ile?Arg?Ala?Glu?Leu?Phe?Thr

25 30 35

cct?ggt?ctg?cag?ttc?ctg?tct?aat?gag?cag?ttc?aac?cag?ctg?ttc?acc 259

Pro?G1y?Leu?Gln?Phe?Leu?Ser?Asn?Glu?Gln?Phe?Asn?Gln?Leu?Phe?Thr

40 45 50

atg?cac?gga?act?gtc?atg?ctg?ctg?ctg?tac?gga?act?cca?att?gtt?tgg 307

Met?His?Gly?Thr?Val?Met?Leu?Leu?Leu?Tyr?Gly?Thr?Pro?Ile?Val?Trp

55 60 65

ggt?ttt?gct?aac?tac?gtc?ctg?cca?ctt?cag?atc?ggt?gcg?cct?gac?gta 355

Gly?Phe?Ala?Asn?Tyr?Val?Leu?Pro?Leu?Gln?Ile?Gly?Ala?Pro?Asp?Val

70 75 80 85

gct?ttc?cca?cgt?ttg?aat?gct?ttc?ggc?ttc?tgg?atc?acc?acc?gtc?ggt 403

Ala?Phe?Pro?Arg?Leu?Asn?Ala?Phe?Gly?Phe?Trp?Ile?Thr?Thr?Val?Gly

90 95 100

ggt?gtc?gcg?atg?ctg?acc?ggc?ttc?ctg?acc?ccg?ggt?ggt?gct?gcc?gac 451

Gly?Val?Ala?Met?Leu?Thr?Gly?Phe?Leu?Thr?Pro?Gly?Gly?Ala?Ala?Asp

105 110 115

ttc?ggt?tgg?acc?atg?tac?tcc?cca?ctg?tct?gac?gca?att?cac?tcc?cca 499

Phe?Gly?Trp?Thr?Met?Tyr?Ser?Pro?Leu?Ser?Asp?Ala?Ile?His?Ser?Pro

120 125 130

ggc?ctt?ggc?tct?gac?atg?tgg?att?gtc?ggt?gtc?ggt?gca?act?ggt?att 547

Gly?Leu?Gly?Ser?Asp?Met?Trp?Ile?Val?Gly?Val?Gly?Ala?Thr?Gly?Ile

135 140 145

ggc?tcc?gtt?gct?tcc?gca?att?aac?atg?ctc?acc?acc?atc?ctc?tgc?ctc 595

Gly?Ser?Val?Ala?Ser?Ala?Ile?Asn?Met?Leu?Thr?Thr?Ile?Leu?Cys?Leu

150 155 160 165

cgc?gca?cct?ggt?atg?acc?atg?ttc?cgt?atg?cct?att?ttc?acc?tgg?aat 643

Arg?Ala?Pro?Gly?Met?Thr?Met?Phe?Arg?Met?Pro?Ile?Phe?Thr?Trp?Asn

170 175 180

atc?ttc?gtt?gtt?tcc?gtt?ctt?gct?ctg?ctg?atc?ttc?cca?ctg?ctg?ctc 691

Ile?Phe?Val?Val?Ser?Val?Leu?Ala?Leu?Leu?Ile?Phe?Pro?Leu?Leu?Leu

185 190 195

gct?gct?gca?ctg?ggt?gtt?ctg?tat?gac?cgc?aag?ctt?ggt?gga?cac?ctg 739

Ala?Ala?Ala?Leu?Gly?Val?Leu?Tyr?Asp?Arg?Lys?Leu?Gly?Gly?His?Leu

200 205 210

tac?gat?cca?gct?aac?ggc?ggc?tcc?ctc?ctg?tgg?cag?cac?ctg?ttc?tgg 787

Tyr?Asp?Pro?Ala?Asn?Gly?Gly?Ser?Leu?Leu?Trp?Gln?His?Leu?Phe?Trp

215 220 225

ttc?ttc?gga?cac?cct?gag?gtt?tac?gtt?ctg?gcg?ctg?ccg?ttc?ttc?ggc 835

Phe?Phe?Gly?His?Pro?Glu?Val?Tyr?Val?Leu?Ala?Leu?Pro?Phe?Phe?Gly

230 235 240 245

att?gtt?tct?gag?atc?att?cct?gtg?ttc?tcc?cgt?aag?cca?atg?ttc?ggt 883

Ile?Val?Ser?Glu?Ile?Ile?Pro?Val?Phe?Ser?Arg?Lys?Pro?Met?Phe?Gly

250 255 260

tac?gtc?ggc?ctg?atc?ttc?gca?acc?ttg?tcc?att?ggt?gca?ctg?tcc?atg 931

Tyr?Val?Gly?Leu?Ile?Phe?Ala?Thr?Leu?Ser?Ile?Gly?Ala?Leu?Ser?Met

265 270 275

gct?gtg?tgg?gct?cac?cac?atg?ttc?gtt?act?ggc?gca?gtt?ttg?ctt?ccg 979

Ala?Val?Trp?Ala?His?His?Met?Phe?Val?Thr?Gly?Ala?Val?Leu?Leu?Pro

280 285 290

ttc?ttc?tcc?ttc?atg?acg?ttc?ctg?att?tcg?gtt?cct?acc?ggc?gtt?aag 1027

Phe?Phe?Ser?Phe?Met?Thr?Phe?Leu?Ile?Ser?Val?Pro?Thr?Gly?Val?Lys

295 300 305

ttc?ttc?aac?tgg?gtt?gga?acc?atg?tgg?aag?ggt?cac?atc?act?tgg?gaa 1075

Phe?Phe?Asn?Trp?Val?Gly?Thr?Met?Trp?Lys?Gly?His?Ile?Thr?Trp?Glu

310 315 320 325

acc?cca?atg?atc?tgg?tct?gtt?ggc?ttc?atg?gct?acc?ttc?ctc?ttc?ggt 1123

Thr?Pro?Met?Ile?Trp?Ser?Val?Gly?Phe?Met?Ala?Thr?Phe?Leu?Phe?Gly

330 335 340

ggt?ctg?acc?ggc?att?atg?ctg?gcg?tcc?cca?cca?ctg?gac?ttc?cac?ttg 1171

Gly?Leu?Thr?Gly?Ile?Met?Leu?Ala?Ser?Pro?Pro?Leu?Asp?Phe?His?Leu

345 350 355

gct?gac?tcc?tac?ttc?ctg?atc?gcg?cac?ttc?cac?tac?acc?ctc?ttc?ggt 1219

Ala?Asp?Ser?Tyr?Phe?Leu?Ile?Ala?His?Phe?His?Tyr?Thr?Leu?Phe?Gly

360 365 370

acc?gtg?gtg?ttc?gca?tcg?tgt?gca?ggc?gtt?tac?ttc?tgg?ttc?ccg?aag 1267

Thr?Val?Val?Phe?Ala?Ser?Cys?Ala?Gly?Val?Tyr?Phe?Trp?Phe?Pro?Lys

375 380 385

atg?act?ggc?cgc?atg?atg?gac?gag?cgt?ctt?ggc?aag?atc?cac?ttc?tgg 1315

Met?Thr?Gly?Arg?Met?Met?Asp?Glu?Arg?Leu?Gly?Lys?Ile?His?Phe?Trp

390 395 400 405

ttg?acc?ttc?gtc?ggt?ttc?cac?gga?acc?ttc?ctc?atc?cag?cac?tgg?gtg 1363

Leu?Thr?Phe?Val?Gly?Phe?His?Gly?Thr?Phe?Leu?Ile?Gln?His?Trp?Val

410 415 420

ggc?aac?atg?ggt?atg?cca?cgt?cgt?tac?gct?gac?tac?ctg?gat?tct?gat 1411

Gly?Asn?Met?Gly?Met?Pro?Arg?Arg?Tyr?Ala?Asp?Tyr?Leu?Asp?Ser?Asp

425 430 435

ggt?ttc?acc?atc?tac?aac?cag?atc?tcc?acc?gtg?ttc?tac?ttc?ctg?ctt 1459

Gly?Phe?Thr?Ile?Tyr?Asn?Gln?Ile?Ser?Thr?Val?Phe?Tyr?Phe?Leu?Leu

440 445 450

ggc?ctg?tct?gtc?att?cca?ttc?atc?tgg?aac?gtc?ttc?aag?tcc?tgg?cgc 1507

Gly?Leu?Ser?Val?Ile?Pro?Phe?Ile?Trp?Asn?Val?Phe?Lys?Ser?Trp?Arg

455 460 465

tac?ggt?gag?ctc?gtt?acc?gtt?gat?gat?cct?tgg?ggt?tac?ggc?aac?tcc 1555

Tyr?Gly?Glu?Leu?Val?Thr?Val?Asp?Asp?Pro?Trp?Gly?Tyr?Gly?Asn?Ser

470 475 480 485

ctg?gag?tgg?gca?acc?tcc?tgc?cct?cct?cct?cgc?cac?aac?ttc?gca?tcc 1603

Leu?Glu?Trp?Ala?Thr?Ser?Cys?Pro?Pro?Pro?Arg?His?Asn?Phe?Ala?Ser

490 495 500

ttg?cct?cgt?atc?cgc?tcc?gag?cgc?cct?gcg?ttc?gag?ctg?cac?tac?ccg 1651

Leu?Pro?Arg?Ile?Arg?Ser?Glu?Arg?Pro?Ala?Phe?Glu?Leu?His?Tyr?Pro

505 510 515

cac?atg?att?gaa?cgc?atg?cgc?gca?gag?gca?cac?act?gga?cat?cac?gat 1699

His?Met?Ile?Glu?Arg?Met?Arg?Ala?Glu?Ala?His?Thr?Gly?His?His?Asp

520 525 530

gat?att?aat?gct?cca?gaa?ttg?ggt?acc?gcc?cca?gcc?ctt?gca?tct?gac 1747

Asp?Ile?Asn?Ala?Pro?Glu?Leu?Gly?Thr?Ala?Pro?Ala?Leu?Ala?Ser?Asp

535 540 545

tcc?agc?cgc?taaaagcgtc?tgatttaagt?cgg 1779

Ser?Ser?Arg

550

<210>654

<211>552

<212>PRT

＜213〉Corynebacterium glutamicum

<400>654

Met?Thr?Thr?Thr?Asp?His?Lys?Gln?Leu?Gly?Ile?Met?Tyr?Ile?Ile?Met

1 5 10 15

Ser?Phe?Ser?Phe?Phe?Phe?Leu?Gly?Gly?Leu?Met?Ala?Leu?Leu?Ile?Arg

20 25 30

Ala?Glu?Leu?Phe?Thr?Pro?Gly?Leu?Gln?Phe?Leu?Ser?Asn?Glu?Gln?Phe

35 40 45

Asn?Gln?Leu?Phe?Thr?Met?His?Gly?Thr?Val?Met?Leu?Leu?Leu?Tyr?Gly

50 55 60

Thr?Pro?Ile?Val?Trp?Gly?Phe?Ala?Asn?Tyr?Val?Leu?Pro?Leu?Gln?Ile

65 70 75 80

Gly?Ala?Pro?Asp?Val?Ala?Phe?Pro?Arg?Leu?Asn?Ala?Phe?Gly?Phe?Trp

85 90 95

Ile?Thr?Thr?Val?Gly?Gly?Val?Ala?Met?Leu?Thr?Gly?Phe?Leu?Thr?Pro

100 105 1l0

Gly?Gly?Ala?Ala?Asp?Phe?Gly?Trp?Thr?Met?Tyr?Ser?Pro?Leu?Ser?Asp

115 120 125

Ala?Ile?His?Ser?Pro?Gly?Leu?Gly?Ser?Asp?Met?Trp?Ile?Val?Gly?Val

130 135 140

Gly?Ala?Thr?Gly?Ile?Gly?Ser?Val?Ala?Ser?Ala?Ile?Asn?Met?Leu?Thr

145 150 155 160

Thr?Ile?Leu?Cys?Leu?Arg?Ala?Pro?Gly?Met?Thr?Met?Phe?Arg?Met?Pro

165 170 175

Ile?Phe?Thr?Trp?Asn?Ile?Phe?Val?Val?Ser?Val?Leu?Ala?Leu?Leu?Ile

180 185 190

Phe?Pro?Leu?Leu?Leu?Ala?Ala?Ala?Leu?Gly?Val?Leu?Tyr?Asp?Arg?Lys

195 200 205

Leu?Gly?Gly?His?Leu?Tyr?Asp?Pro?Ala?Asn?Gly?Gly?Ser?Leu?Leu?Trp

210 215 220

Gln?His?Leu?Phe?Trp?Phe?Phe?Gly?His?Pro?Glu?Val?Tyr?Val?Leu?Ala

225 230 235 240

Leu?Pro?Phe?Phe?Gly?Ile?Val?Ser?Glu?Ile?Ile?Pro?Val?Phe?Ser?Arg

245 250 255

Lys?Pro?Met?Phe?Gly?Tyr?Val?Gly?Leu?Ile?Phe?Ala?Thr?Leu?Ser?Ile

260 265 270

Gly?Ala?Leu?Ser?Met?Ala?Val?Trp?Ala?His?His?Met?Phe?Val?Thr?Gly

275 280 285

Ala?Val?Leu?Leu?Pro?Phe?Phe?Ser?Phe?Met?Thr?Phe?Leu?Ile?Ser?Val

290 295 300

Pro?Thr?Gly?Val?Lys?Phe?Phe?Asn?Trp?Val?Gly?Thr?Met?Trp?Lys?Gly

305 310 315 320

His?Ile?Thr?Trp?Glu?Thr?Pro?Met?Ile?Trp?Ser?Val?Gly?Phe?Met?Ala

325 330 335

Thr?Phe?Leu?Phe?Gly?Gly?Leu?Thr?Gly?Ile?Met?Leu?Ala?Ser?Pro?Pro

340 345 350

Leu?Asp?Phe?His?Leu?Ala?Asp?Ser?Tyr?Phe?Leu?Ile?Ala?His?Phe?His

355 360 365

Tyr?Thr?Leu?Phe?Gly?Thr?Val?Val?Phe?Ala?Ser?Cys?Ala?Gly?Val?Tyr

370 375 380

Phe?Trp?Phe?Pro?Lys?Met?Thr?Gly?Arg?Met?Met?Asp?Glu?Arg?Leu?Gly

385 390 395 400

Lys?Ile?His?Phe?Trp?Leu?Thr?Phe?Val?Gly?Phe?His?Gly?Thr?Phe?Leu

405 410 415

Ile?Gln?His?Trp?Val?Gly?Asn?Met?Gly?Met?Pro?Arg?Arg?Tyr?Ala?Asp

420 425 430

Tyr?Leu?Asp?Ser?Asp?Gly?Phe?Thr?Ile?Tyr?Asn?Gln?Ile?Ser?Thr?Val

435 440 445

Phe?Tyr?Phe?Leu?Leu?Gly?Leu?Ser?Val?Ile?Pro?Phe?Ile?Trp?Asn?Val

450 455 460

Phe?Lys?Ser?Trp?Arg?Tyr?Gly?Glu?Leu?Val?Thr?Val?Asp?Asp?Pro?Trp

465 470 475 480

Gly?Tyr?Gly?Asn?Ser?Leu?Glu?Trp?Ala?Thr?Ser?Cys?Pro?Pro?Pro?Arg

485 490 495

His?Asn?Phe?Ala?Ser?Leu?Pro?Arg?Ile?Arg?Ser?Glu?Arg?Pro?Ala?Phe

500 505 510

Glu?Leu?His?Tyr?Pro?His?Met?Ile?Glu?Arg?Met?Arg?Ala?Glu?Ala?His

515 520 525

Thr?Gly?His?His?Asp?Asp?Ile?Asn?Ala?Pro?Glu?Leu?Gly?Thr?Ala?Pro

530 535 540

Ala?Leu?Ala?Ser?Asp?Ser?Ser?Arg

545 550

<210>655

<211>385

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(385)

<223>FRXA01919

<220>

＜221〉further feature

<222>345

<223>n＝a，c，g，or?t

<220>

＜221〉varient

<222>82

<223>Xaa＝Met，Thr，Lys，or?Arg

<400>655

acctatgacc?gctgtggcgc?ctagggtcga?cgggcacgtc?gcccctcaga?ggcccgagcc?60

gacaggccat?gcacgcaagg?gcagcaaagc?atggttaatg?atg?acc?acc?acc?gac 115

Met?Thr?Thr?Thr?Asp

1 5

cac?aag?cag?ctg?ggc?att?atg?tac?atc?att?atg?tcc?ttc?agc?ttc?ttt 163

His?Lys?Gln?Leu?Gly?Ile?Met?Tyr?Ile?Ile?Met?Ser?Phe?Ser?Phe?Phe

10 15 20

ttc?ctc?ggt?ggc?ttg?atg?gcc?ctg?ctt?atc?cga?gcg?gag?ctt?ttc?acc 211

Phe?Leu?Gly?Gly?Leu?Met?Ala?Leu?Leu?Ile?Arg?Ala?Glu?Leu?Phe?Thr

25 30 35

cct?ggt?ctg?cag?ttc?ctg?tct?aat?gag?cag?ttc?aac?cag?ctg?ttc?acc 259

Pro?Gly?Leu?Gln?Phe?Leu?Ser?Asn?Glu?Gln?Phe?Asn?Gln?Leu?Phe?Thr

40 45 50

atg?cac?gga?act?gtc?atg?ctg?ctg?ctg?tac?gga?act?cca?att?gtt?tgg 307

Met?His?GIy?Thr?Val?Met?Leu?Leu?Leu?Tyr?Gly?Thr?Pro?Ile?Val?Trp

55 60 65

ggt?ttt?gct?aac?tac?gtc?ctg?cca?ctt?cca?acc?acc?ang?caa?gcc?ttc 355

Gly?Phe?Ala?Asn?Tyr?Val?Leu?Pro?Leu?Pro?Thr?Thr?Xaa?Gln?Ala?Phe

70 75 80 85

tct?aaa?acc?cgg?gtg?aac?tct?ccc?agg?gag 385

Ser?Lys?Thr?Arg?Val?Asn?Ser?Pro?Arg?Glu

90 95

<210>656

<211>95

<212>PRT

＜213〉Corynebacterium glutamicum

<220>

＜221〉varient

<222>82

<223>Xaa＝Met，Thr，Lys，or?Arg

<400>656

Met?Thr?Thr?Thr?Asp?His?Lys?Gln?Leu?Gly?Ile?Met?Tyr?Ile?Ile?Met

1 5 10 15

Ser?Phe?Ser?Phe?Phe?Phe?Leu?Gly?Gly?Leu?Met?Ala?Leu?Leu?Ile?Arg

20 25 30

Ala?Glu?Leu?Phe?Thr?Pro?Gly?Leu?Gln?Phe?Leu?Ser?Asn?Glu?Gln?Phe

35 40 45

Asn?Gln?Leu?Phe?Thr?Met?His?Gly?Thr?Val?Met?Leu?Leu?Leu?Tyr?Gly

50 55 60

Thr?Pro?Ile?Val?Trp?Gly?Phe?Ala?Asn?Tyr?Val?Leu?Pro?Leu?Pro?Thr

65 70 75 80

Thr?Xaa?Gln?Ala?Phe?Ser?Lys?Thr?Arg?Val?Asn?Ser?Pro?Arg?Glu

85 90 95

<210>657

<211>972

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(949)

<223>FRXA02480

<400>657

tacgttctgg?cgctgccgtt?cttcggcatt?gtttctgaga?tcattcctgt?gttctcccgt?60

aagccaatgt?tcgggttacg?tcggcctgat?cttcgcaacc?ttg?tcc?att?ggt?gca 115

Leu?Ser?Ile?Gly?Ala

1 5

ctg?tcc?atg?gct?gtg?tgg?gct?cac?cac?atg?ttc?gtt?act?ggc?gca?gtt 163

Leu?Ser?Met?Ala?Val?Trp?Ala?His?His?Met?Phe?Val?Thr?Gly?Ala?Val

10 15 20

ttg?ctt?ccg?ttc?ttc?tcc?ttc?atg?acg?ttc?ctg?att?tcg?gtt?cct?acc 211

Leu?Leu?Pro?Phe?Phe?Ser?Phe?Met?Thr?Phe?Leu?Ile?Ser?Val?Pro?Thr

25 30 35

ggc?gtt?aag?ttc?ttc?aac?tgg?gtt?gga?acc?atg?tgg?aag?ggt?cac?atc 259

Gly?Val?Lys?Phe?Phe?Asn?Trp?Val?Gly?Thr?Met?Trp?Lys?Gly?His?Ile

40 45 50

act?tgg?gaa?acc?cca?atg?atc?tgg?tct?gtt?ggc?ttc?atg?gct?acc?ttc 307

Thr?Trp?Glu?Thr?Pro?Met?Ile?Trp?Ser?Val?Gly?Phe?Met?Ala?Thr?Phe

55 60 65

ctc?ttc?ggt?ggt?ctg?acc?ggc?att?atg?ctg?gcg?tcc?cca?cca?ctg?gac 355

Leu?Phe?Gly?Gly?Leu?Thr?Gly?Ile?Met?Leu?Ala?Ser?Pro?Pro?Leu?Asp

70 75 80 85

ttc?cac?ttg?gct?gac?tcc?tac?ttc?ctg?atc?gcg?cac?ttc?cac?tac?acc 403

Phe?His?Leu?Ala?Asp?Ser?Tyr?Phe?Leu?Ile?Ala?His?Phe?His?Tyr?Thr

90 95 100

ctc?ttc?ggt?acc?gtg?gtg?ttc?gca?tcg?tgt?gca?ggc?gtt?tac?ttc?tgg 451

Leu?Phe?Gly?Thr?Val?Val?Phe?Ala?Ser?Cys?Ala?Gly?Val?Tyr?Phe?Trp

105 110 115

ttc?ccg?aag?atg?act?ggc?cgc?atg?atg?gac?gag?cgt?ctt?ggc?aag?atc 499

Phe?Pro?Lys?Met?Thr?Gly?Arg?Met?Met?Asp?Glu?Arg?Leu?Gly?Lys?Ile

120 125 130

cac?ttc?tgg?ttg?acc?ttc?gtc?ggt?ttc?cac?gga?acc?ttc?ctc?atc?cag 547

His?Phe?Trp?Leu?Thr?Phe?Val?Gly?Phe?His?Gly?Thr?Phe?Leu?Ile?Gln

135 140 145

cac?tgg?gtg?ggc?aac?atg?ggt?atg?cca?cgt?cgt?tac?gct?gac?tac?ctg 595

His?Trp?Val?Gly?Asn?Met?Gly?Met?Pro?Arg?Arg?Tyr?Ala?Asp?Tyr?Leu

150 155 160 165

gat?tct?gat?ggt?ttc?acc?atc?tac?aac?cag?atc?tcc?acc?gtg?ttc?tac 643

Asp?Ser?Asp?Gly?Phe?Thr?Ile?Tyr?Asn?Gln?Ile?Ser?Thr?Val?Phe?Tyr

170 175 180

ttc?ctg?ctt?ggc?ctg?tct?gtc?att?cca?ttc?atc?tgg?aac?gtc?ttc?aag 691

Phe?Leu?Leu?Gly?Leu?Ser?Val?Ile?Pro?Phe?Ile?Trp?Asn?Val?Phe?Lys

185 190 195

tcc?tgg?cgc?tac?ggt?gag?ctc?gtt?acc?gtt?gat?gat?cct?tgg?ggt?tac 739

Ser?Trp?Arg?Tyr?Gly?Glu?Leu?Val?Thr?Val?Asp?Asp?Pro?Trp?Gly?Tyr

200 205 210

ggc?aac?tcc?ctg?gag?tgg?gca?acc?tcc?tgc?cct?cct?cct?cgc?cac?aac 787

Gly?Asn?Ser?Leu?Glu?Trp?Ala?Thr?Ser?Cys?Pro?Pro?Pro?Arg?His?Asn

215 220 225

ttc?gca?tcc?ttg?cct?cgt?atc?cgc?tcc?gag?cgc?cct?gcg?ttc?gag?ctg 835

Phe?Ala?Ser?Leu?Pro?Arg?Ile?Arg?Ser?Glu?Arg?Pro?Ala?Phe?Glu?Leu

230 235 240 245

cac?tac?ccg?cac?atg?att?gaa?cgc?atg?cgc?gca?gag?gca?cac?act?gga 883

His?Tyr?Pro?His?Met?Ile?Glu?Arg?Met?Arg?Ala?Glu?Ala?His?Thr?Gly

250 255 260

cat?cac?gat?gat?att?aat?gct?cca?gaa?ttg?ggt?acc?gcc?cca?gcc?ctt 931

His?His?Asp?Asp?Ile?Asn?Ala?Pro?Glu?Leu?Gly?Thr?Ala?Pro?Ala?Leu

265 270 275

gca?tct?gac?tcc?agc?cgc?taaaagcgtc?tgatttaagt?cgg 972

Ala?Ser?Asp?Ser?Ser?Arg

280

<210>658

<211>283

<212>PRT

＜213〉Corynebacterium glutamicum

<400>658

Leu?Ser?Ile?Gly?Ala?Leu?Ser?Met?Ala?Val?Trp?Ala?His?His?Met?Phe

1 5 10 15

Val?Thr?Gly?Ala?Val?Leu?Leu?Pro?Phe?Phe?Ser?Phe?Met?Thr?Phe?Leu

20 25 30

Ile?Ser?Val?Pro?Thr?Gly?Val?Lys?Phe?Phe?Asn?Trp?Val?Gly?Thr?Met

35 40 45

Trp?Lys?Gly?His?Ile?Thr?Trp?Glu?Thr?Pro?Met?Ile?Trp?Ser?Val?Gly

50 55 60

Phe?Met?Ala?Thr?Phe?Leu?Phe?Gly?Gly?Leu?Thr?Gly?Ile?Met?Leu?Ala

65 70 75 80

Ser?Pro?Pro?Leu?Asp?Phe?His?Leu?Ala?Asp?Ser?Tyr?Phe?Leu?Ile?Ala

85 90 95

His?Phe?His?Tyr?Thr?Leu?Phe?Gly?Thr?Val?Val?Phe?Ala?Ser?Cys?Ala

100 105 110

Gly?Val?Tyr?Phe?Trp?Phe?Pro?Lys?Met?Thr?Gly?Arg?Met?Met?Asp?Glu

115 120 125

Arg?Leu?Gly?Lys?Ile?His?Phe?Trp?Leu?Thr?Phe?Val?Gly?Phe?His?Gly

130 135 140

Thr?Phe?Leu?Ile?Gln?His?Trp?Val?Gly?Asn?Met?Gly?Met?Pro?Arg?Arg

145 150 155 160

Tyr?Ala?Asp?Tyr?Leu?Asp?Ser?Asp?Gly?Phe?Thr?Ile?Tyr?Asn?Gln?Ile

165 170 175

Ser?Thr?Val?Phe?Tyr?Phe?Leu?Leu?Gly?Leu?Ser?Val?Ile?Pro?Phe?Ile

180 185 190

Trp?Asn?Val?Phe?Lys?Ser?Trp?Arg?Tyr?Gly?Glu?Leu?Val?Thr?Val?Asp

195 200 205

Asp?Pro?Trp?Gly?Tyr?Gly?Asn?Ser?Leu?Glu?Trp?Ala?Thr?Ser?Cys?Pro

210 215 220

Pro?Pro?Arg?His?Asn?Phe?Ala?Ser?Leu?Pro?Arg?Ile?Arg?Ser?Glu?Arg

225 230 235 240

Pro?Ala?Phe?Glu?Leu?His?Tyr?Pro?His?Met?Ile?Glu?Arg?Met?Arg?Ala

245 250 255

Glu?Ala?His?Thr?Gly?His?His?Asp?Asp?Ile?Asn?Ala?Pro?Glu?Leu?Gly

260 265 270

Thr?Ala?Pro?Ala?Leu?Ala?Ser?Asp?Ser?Ser?Arg

275 280

<210>659

<211>735

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(712)

<223>FRXA02481

<400>659

tgctaactac?gtcctgccac?ttcagatcgg?tgcgcctgac?gtagctttcc?cacgttgaaa?60

tgctttcggc?ttctgaatca?ccaccgtcgg?tggtgtcgcg?atg?ctg?acc?ggc?ttc 115

Met?Leu?Thr?Gly?Phe

1 5

cta?acc?ccg?ggt?ggt?gct?gcc?gac?ttg?ggt?gga?cca?tgt?act?ccc?cac 163

Leu?Thr?Pro?Gly?Gly?Ala?Ala?Asp?Leu?Gly?Gly?Pro?Cys?Thr?Pro?His

10 15 20

tgt?ctg?acg?caa?ttc?act?ccc?cag?gcc?ttg?gtt?cta?aca?tgt?gga?ttg 211

Cys?Leu?Thr?Gln?Phe?Thr?Pro?Gln?Ala?Leu?Val?Leu?Thr?Cys?Gly?Leu

25 30 35

tcg?ggt?gtc?ggt?gca?act?ggt?att?ggc?tcc?gtt?gct?tcc?gca?att?aac 259

Ser?Gly?Val?Gly?Ala?Thr?Gly?Ile?Gly?Ser?Val?Ala?Ser?Ala?Ile?Asn

40 45 50

atg?ctc?acc?acc?atc?ctc?tgc?ctc?cgc?gca?cct?ggt?atg?acc?atg?ttc 307

Met?Leu?Thr?Thr?Ile?Leu?Cys?Leu?Arg?Ala?Pro?Gly?Met?Thr?Met?Phe

55 60 65

cgt?atg?cct?att?ttc?acc?tgg?aat?atc?ttc?gtt?gtt?tcc?gtt?ctt?gct 355

Arg?Met?Pro?Ile?Phe?Thr?Trp?Asn?Ile?Phe?Val?Val?Ser?Val?Leu?Ala

70 75 80 85

ctg?ctg?atc?ttc?cca?ctg?ctg?ctc?gct?gct?gca?ctg?ggt?gtt?ctg?tat 403

Leu?Leu?Ile?Phe?Pro?Leu?Leu?Leu?Ala?Ala?Ala?Leu?Gly?Val?Leu?Tyr

90 95 100

gac?cgc?aag?ctt?ggt?gga?cac?ctg?tac?gat?cca?gct?aac?ggc?ggc?tcc 451

Asp?Arg?Lys?Leu?Gly?Gly?His?Leu?Tyr?Asp?Pro?Ala?Asn?Gly?Gly?Ser

105 110 115

ctc?ctg?tgg?cag?cac?ctg?ttc?tgg?ttc?ttc?gga?cac?cct?gag?gtt?tac 499

Leu?Leu?Trp?Gln?His?Leu?Phe?Trp?Phe?Phe?Gly?His?Pro?Glu?Val?Tyr

120 125 130

gtt?ctg?gcg?ctg?ccg?ttc?ttc?ggc?att?gtt?tct?gag?atc?att?cct?gtg 547

Val?Leu?Ala?Leu?Pro?Phe?Phe?Gly?Ile?Val?Ser?Glu?Ile?Ile?Pro?Val

135 140 145

ttc?tcc?cgt?aag?cca?atg?ttc?ggg?tta?cgt?cgg?cct?gat?ctt?cgc?aac 595

Phe?Ser?Arg?Lys?Pro?Met?Phe?Gly?Leu?Arg?Arg?Pro?Asp?Leu?Arg?Asn

150 155 160 165

ctt?gtc?cat?tgg?tgc?act?gtc?cat?ggc?tgt?gtg?ggc?tca?cca?cat?gtt 643

Leu?Val?His?Trp?Cys?Thr?Val?His?Gly?Cys?Val?Gly?Ser?Pro?His?Val

170 175 180

cgt?tac?tgg?cgc?agt?ttt?gct?tcc?gtt?ctt?ctc?ctt?cat?gac?gtt?cct 691

Arg?Tyr?Trp?Arg?Ser?Phe?Ala?Ser?Val?Leu?Leu?Leu?His?Asp?Val?Pro

185 190 195

gat?ttc?ggt?tcc?tac?cgg?cgt?taagttcttc?aactgggttg?gaa 735

Asp?Phe?Gly?Ser?Tyr?Arg?Arg

200

<210>660

<211>204

<212>PRT

＜213〉Corynebacterium glutamicum

<400>660

Met?Leu?Thr?Gly?Phe?Leu?Thr?Pro?Gly?Gly?Ala?Ala?Asp?Leu?Gly?Gly

1 5 10 15

Pro?Cys?Thr?Pro?His?Cys?Leu?Thr?Gln?Phe?Thr?Pro?Gln?Ala?Leu?Val

20 25 30

Leu?Thr?Cys?Gly?Leu?Ser?Gly?Val?Gly?Ala?Thr?Gly?Ile?Gly?Ser?Val

35 40 45

Ala?Ser?Ala?Ile?Asn?Met?Leu?Thr?Thr?Ile?Leu?Cys?Leu?Arg?Ala?Pro

50 55 60

Gly?Met?Thr?Met?Phe?Arg?Met?Pro?Ile?Phe?Thr?Trp?Asn?Ile?Phe?Val

65 70 75 80

Val?Ser?Val?Leu?Ala?Leu?Leu?Ile?Phe?Pro?Leu?Leu?Leu?Ala?Ala?Ala

85 90 95

Leu?Gly?Val?Leu?Tyr?Asp?Arg?Lys?Leu?Gly?Gly?His?Leu?Tyr?Asp?Pro

100 105 110

Ala?Asn?Gly?Gly?Ser?Leu?Leu?Trp?Gln?His?Leu?Phe?Trp?Phe?Phe?Gly

115 120 125

His?Pro?Glu?Val?Tyr?Val?Leu?Ala?Leu?Pro?Phe?Phe?Gly?Ile?Val?Ser

130 135 140

Glu?Ile?Ile?Pro?Val?Phe?Ser?Arg?Lys?Pro?Met?Phe?Gly?Leu?Arg?Arg

145 150 155 160

Pro?Asp?Leu?Arg?Asn?Leu?Val?His?Trp?Cys?Thr?Val?His?Gly?Cys?Val

165 170 175

Gly?Ser?Pro?His?Val?Arg?Tyr?Trp?Arg?Ser?Phe?Ala?Ser?Val?Leu?Leu

180 185 190

Leu?His?Asp?Val?Pro?Asp?Phe?Gly?Ser?Tyr?Arg?Arg

195 200

<210>661

<211>1200

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1177)

<223>RXA02140

<400>661

aacacaagat?atggaatcgg?ctggcaaata?ggctattctg?cgaagataga?aatgaccgta?60

aggtctctgg?tttttgtgtg?gacaggaagg?cagaacacac?gtg?gaa?cag?caa?aat 115

Val?Glu?Gln?Gln?Asn

1 5

aag?cgt?ggt?tta?aag?cgc?aag?gcc?ctg?ctt?ggc?ggt?gtc?ttg?ggc?tta 163

Lys?Arg?Gly?Leu?Lys?Arg?Lys?Ala?Leu?Leu?Gly?Gly?Val?Leu?Gly?Leu

10 15 20

ggt?ggc?ctc?gcc?atg?gca?ggc?tgt?gaa?gtc?gcc?cct?cct?ggc?ggt?gtg 211

Gly?Gly?Leu?Ala?Met?Ala?Gly?Cys?Glu?Val?Ala?Pro?Pro?Gly?Gly?Val

25 30 35

ctt?gga?gat?ttc?cta?cgt?atg?ggt?tgg?cct?gat?ggc?att?acc?cct?gaa 259

Leu?Gly?Asp?Phe?Leu?Arg?Met?Gly?Trp?Pro?Asp?Gly?Ile?Thr?Pro?Glu

40 45 50

gca?gtg?gcc?atg?ggt?aac?ttc?tgg?tca?tgg?gtc?tgg?gtt?gct?gcc?tgg 307

Ala?Val?Ala?Met?Gly?Asn?Phe?Trp?Ser?Trp?Val?Trp?Val?Ala?Ala?Trp

55 60 65

atc?atc?ggc?atc?atc?atg?tgg?ggt?cta?ttc?ctc?acc?gcc?atc?ttt?gcc 355

Ile?Ile?Gly?Ile?Ile?Met?Trp?Gly?Leu?Phe?Leu?Thr?Ala?Ile?Phe?Ala

70 75 80 85

tgg?ggc?gca?aag?agg?gct?gaa?aag?cgc?ggc?gag?ggt?gaa?ttc?cct?aag 403

Trp?Gly?Ala?Lys?Arg?Ala?Glu?Lys?Arg?Gly?Glu?Gly?Glu?Phe?Pro?Lys

90 95 100

cag?ctc?cag?tac?aac?gtt?cca?ctt?gag?ctc?gtt?ctg?acg?atc?gtt?ccg 451

Gln?Leu?Gln?Tyr?Asn?Val?Pro?Leu?Glu?Leu?Val?Leu?Thr?Ile?Val?Pro

105 110 115

atc?atc?att?gtt?atg?gtg?ctg?ttc?ttc?ttc?acc?gtt?caa?act?cag?gac 499

Ile?Ile?Ile?Val?Met?Val?Leu?Phe?Phe?Phe?Thr?Val?Gln?Thr?Gln?Asp

120 125 130

aag?gtc?acc?gct?ctg?gat?aag?aac?cca?gag?gtt?acc?gtg?gac?gtc?acc 547

Lys?Val?Thr?Ala?Leu?Asp?Lys?Asn?Pro?Glu?Val?Thr?Val?Asp?Val?Thr

135 140 145

gct?tac?cag?tgg?aac?tgg?aag?ttc?gga?tac?tcc?gaa?att?gat?ggc?tca 595

Ala?Tyr?Gln?Trp?Asn?Trp?Lys?Phe?Gly?Tyr?Ser?Glu?Ile?Asp?Gly?Ser

150 155 160 165

ctg?gca?cct?ggt?gga?cag?gat?tac?caa?gga?agc?gac?ccg?gag?cgt?cag 643

Leu?Ala?Pro?Gly?Gly?Gln?Asp?Tyr?Gln?Gly?Ser?Asp?Pro?Glu?Arg?Gln

170 175 180

gca?gct?gcc?gag?gct?tcc?aag?aag?gat?cct?tct?gga?gat?aac?cca?att 691

Ala?Ala?Ala?Glu?Ala?Ser?Lys?Lys?Asp?Pro?Ser?Gly?Asp?Asn?Pro?Ile

185 190 195

cac?ggc?aac?tca?aag?tct?gac?gtt?tct?tac?ctt?gag?ttc?aac?cga?att 739

His?Gly?Asn?Ser?Lys?Ser?Asp?Val?Ser?Tyr?Leu?Glu?Phe?Asn?Arg?Ile

200 205 210

gaa?acc?ctc?gga?acc?act?gat?gaa?atc?cca?gtg?atg?gtt?ctt?cct?gtg 787

Glu?Thr?Leu?Gly?Thr?Thr?Asp?Glu?Ile?Pro?Val?Met?Val?Leu?Pro?Val

215 220 225

aac?acc?cca?atc?gag?ttc?aac?ctc?gca?tct?gct?gac?gtt?gca?cac?tcc 835

Asn?Thr?Pro?Ile?Glu?Phe?Asn?Leu?Ala?Ser?Ala?Asp?Val?Ala?His?Ser

230 235 240 245

ttc?tgg?gtt?cca?gag?ttc?ctc?ttc?aag?cga?gat?gct?tac?gca?cac?cct 883

Phe?Trp?Val?Pro?Glu?Phe?Leu?Phe?Lys?Arg?Asp?Ala?Tyr?Ala?His?Pro

250 255 260

gag?gca?aac?aag?tcc?cag?cgt?gtc?ttc?cag?att?gaa?gag?atc?act?gag 931

Glu?Ala?Asn?Lys?Ser?Gln?Arg?Val?Phe?Gln?Ile?Glu?Glu?Ile?Thr?Glu

265 270 275

gaa?ggc?gca?ttc?gtt?ggt?cgc?tgt?gca?gaa?atg?tgc?ggt?act?tac?cac 979

Glu?Gly?Ala?Phe?Val?Gly?Arg?Cys?Ala?Glu?Met?Cys?Gly?Thr?Tyr?His

280 285 290

gca?atg?atg?aac?ttc?gag?ctt?cgt?gtc?gtc?gat?cgc?gat?tcc?ttc?gct 1027

Ala?Met?Met?Asn?Phe?Glu?Leu?Arg?Val?Val?Asp?Arg?Asp?Ser?Phe?Ala

295 300 305

gag?tac?atc?agc?ttc?cgt?gac?tcc?aac?cca?gac?gca?acc?aac?gct?cag 1075

Glu?Tyr?Ile?Ser?Phe?Arg?Asp?Ser?Asn?Pro?Asp?Ala?Thr?Asn?Ala?Gln

310 315 320 325

gca?ctt?gag?cac?att?ggt?caa?gct?cct?tac?gct?act?tcc?act?agc?cca 1123

Ala?Leu?Glu?His?Ile?Gly?Gln?Ala?Pro?Tyr?Ala?Thr?Ser?Thr?Ser?Pro

330 335 340

ttc?gtt?tcc?gat?cgc?acc?gca?acc?cgc?gac?ggc?gaa?aac?act?cag?agc 1171

Phe?Val?Ser?Asp?Arg?Thr?Ala?Thr?Arg?Asp?Gly?Glu?Asn?Thr?Gln?Ser

345 350 355

aac?gct?taagaaggag?tggcgaaaaa?atg 1200

Asn?Ala

<210>662

<211>359

<212>PRT

＜213〉Corynebacterium glutamicum

<400>662

Val?Glu?Gln?Gln?Asn?Lys?Arg?Gly?Leu?Lys?Arg?Lys?Ala?Leu?Leu?Gly

1 5 10 15

Gly?Val?Leu?Gly?Leu?Gly?Gly?Leu?Ala?Met?Ala?Gly?Cys?Glu?Val?Ala

20 25 30

Pro?Pro?Gly?Gly?Val?Leu?Gly?Asp?Phe?Leu?Arg?Met?Gly?Trp?Pro?Asp

35 40 45

Gly?Ile?Thr?Pro?Glu?Ala?Val?Ala?Met?Gly?Asn?Phe?Trp?Ser?Trp?Val

50 55 60

Trp?Val?Ala?Ala?Trp?Ile?Ile?Gly?Ile?Ile?Met?Trp?Gly?Leu?Phe?Leu

65 70 75 80

Thr?Ala?Ile?Phe?Ala?Trp?Gly?Ala?Lys?Arg?Ala?Glu?Lys?Arg?Gly?Glu

85 90 95

Gly?Glu?Phe?Pro?Lys?Gln?Leu?Gln?Tyr?Asn?Val?Pro?Leu?Glu?Leu?Val

100 105 110

Leu?Thr?Ile?Val?Pro?Ile?Ile?Ile?Val?Met?Val?Leu?Phe?Phe?Phe?Thr

115 120 125

Val?Gln?Thr?Gln?Asp?Lys?Val?Thr?Ala?Leu?Asp?Lys?Asn?Pro?Glu?Val

130 135 140

Thr?Val?Asp?Val?Thr?Ala?Tyr?Gln?Trp?Asn?Trp?Lys?Phe?Gly?Tyr?Ser

145 150 155 160

Glu?Ile?Asp?Gly?Ser?Leu?Ala?Pro?Gly?Gly?Gln?Asp?Tyr?Gln?Gly?Ser

165 170 175

Asp?Pro?Glu?Arg?Gln?Ala?Ala?Ala?Glu?Ala?Ser?Lys?Lys?Asp?Pro?Ser

180 185 190

Gly?Asp?Asn?Pro?Ile?His?Gly?Asn?Ser?Lys?Ser?Asp?Val?Ser?Tyr?Leu

l95 200 205

Glu?Phe?Asn?Arg?Ile?Glu?Thr?Leu?Gly?Thr?Thr?Asp?Glu?Ile?Pro?Val

210 215 220

Met?Val?Leu?Pro?Val?Asn?Thr?Pro?Ile?Glu?Phe?Asn?Leu?Ala?Ser?Ala

225 230 235 240

Asp?Val?Ala?His?Ser?Phe?Trp?Val?Pro?Glu?Phe?Leu?Phe?Lys?Arg?Asp

245 250 255

Ala?Tyr?Ala?His?Pro?Glu?Ala?Asn?Lys?Ser?Gln?Arg?Val?Phe?Gln?Ile

260 265 270

Glu?Glu?Ile?Thr?Glu?Glu?Gly?Ala?Phe?Val?Gly?Arg?Cys?Ala?Glu?Met

275 280 285

Cys?Gly?Thr?Tyr?His?Ala?Met?Met?Asn?Phe?Glu?Leu?Arg?Val?Val?Asp

290 295 300

Arg?Asp?Ser?Phe?Ala?Glu?Tyr?Ile?Ser?Phe?Arg?Asp?Ser?Asn?Pro?Asp

305 310 315 320

Ala?Thr?Asn?Ala?Gln?Ala?Leu?Glu?His?Ile?Gly?Gln?Ala?Pro?Tyr?Ala

325 330 335

Thr?Ser?Thr?Ser?Pro?Phe?Val?Ser?Asp?Arg?Thr?Ala?Thr?Arg?Asp?Gly

340 345 350

Glu?Asn?Thr?Gln?Ser?Asn?Ala

355

<210>663

<211>774

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(751)

<223>RXA02142

<400>663

acgaaaagtt?cccggaaggt?cgattgaaaa?gtttgcgaat?tgggggaaaa?ttcgcatcaa?60

aagccgagtt?caaactttca?attgaaacgg?ggggcttgaa?gtg?act?ttg?gcc?aac 115

Val?Thr?Leu?Ala?Asn

1 5

caa?aca?gcc?ata?cta?gat?agc?gtg?acg?agc?gca?gtt?gga?aat?aca?ggt 163

Gln?Thr?Ala?Ile?Leu?Asp?Ser?Val?Thr?Ser?Ala?Val?Gly?Asn?Thr?Gly

10 15 20

atg?gca?gca?cca?caa?cgt?gtt?gcg?gca?ctg?aac?cgt?ccg?aat?atg?gtc 211

Met?Ala?Ala?Pro?Gln?Arg?Val?Ala?Ala?Leu?Asn?Arg?Pro?Asn?Met?Val

25 30 35

agt?gtc?ggc?acc?att?gtg?ttc?ctg?tct?cag?gaa?tta?atg?ttc?ttc?gcc 259

Ser?Val?Gly?Thr?Ile?Val?Phe?Leu?Ser?Gln?Glu?Leu?Met?Phe?Phe?Ala

40 45 50

ggg?cta?ttc?gcg?atg?tac?ttc?gtg?tcc?cgt?gcg?aac?gga?ctg?gca?aat 307

Gly?Leu?Phe?Ala?Met?Tyr?Phe?Val?Ser?Arg?Ala?Asn?Gly?Leu?Ala?Asn

55 60 65

gga?tca?tgg?gga?gag?cag?aca?gat?cac?ctc?aac?gtg?ccc?tac?gca?ctg 355

Gly?Ser?Trp?Gly?Glu?Gln?Thr?Asp?His?Leu?Asn?Val?Pro?Tyr?Ala?Leu

70 75 80 85

ttg?att?acg?gtc?att?ctg?gtg?tct?tcc?tca?gtg?act?tgc?cag?ttc?gga 403

Leu?Ile?Thr?Val?Ile?Leu?Val?Ser?Ser?Ser?Val?Thr?Cys?Gln?Phe?Gly

90 95 100

gtt?ttt?gcg?gct?gaa?agg?ggt?gac?gtt?tac?ggc?ctc?cgc?aag?tgg?ttc 451

Val?Phe?Ala?Ala?Glu?Arg?Gly?Asp?Val?Tyr?Gly?Leu?Arg?Lys?Trp?Phe

105 110 115

ttg?gtc?acg?att?atc?ctc?gga?tca?atc?ttc?gtg?atc?gga?cag?ggc?tac 499

Leu?Val?Thr?Ile?Ile?Leu?Gly?Ser?Ile?Phe?Val?Ile?Gly?Gln?Gly?Tyr

120 125 130

gag?tac?atc?act?ctc?gta?ggt?cac?gga?ctt?aca?atc?cag?agc?agt?gtc 547

Glu?Tyr?Ile?Thr?Leu?Val?Gly?His?Gly?Leu?Thr?Ile?Gln?Ser?Ser?Val

135 140 145

tac?gga?tcg?gca?ttc?ttt?att?aca?acc?ggt?ttc?cac?gca?ctg?cac?gtg 595

Tyr?Gly?Ser?Ala?Phe?Phe?Ile?Thr?Thr?Gly?Phe?His?Ala?Leu?His?Val

150 155 160 165

atc?gcg?ggt?gtt?atg?gcc?ttc?gtt?gtg?gtt?ctt?atg?aga?atc?cat?aag 643

Ile?Ala?Gly?Val?Met?Ala?Phe?Val?Val?Val?Leu?Met?Arg?Ile?His?Lys

170 175 180

tcg?aag?ttc?act?ccg?gca?cag?gca?acc?gca?gca?atg?gtt?gtg?tct?tat 691

Ser?Lys?Phe?Thr?Pro?Ala?Gln?Ala?Thr?Ala?Ala?Met?Val?Val?Ser?Tyr

185 190 195

tac?tgg?cac?ttc?gtt?gac?gtg?gtc?tgg?atc?ggc?ctc?ttc?atc?act?att 739

Tyr?Trp?His?Phe?Val?Asp?Val?Val?Trp?Ile?Gly?Leu?Phe?Ile?Thr?Ile

200 205 210

tac?ttc?att?cag?taggcagtaa?ggaatcctca?acg 774

Tyr?Phe?Ile?Gln

215

<210>664

<211>217

<212>PRT

＜213〉Corynebacterium glutamicum

<400>664

Val?Thr?Leu?Ala?Asn?Gln?Thr?Ala?Ile?Leu?Asp?Ser?Val?Thr?Ser?Ala

1 5 10 15

Val?Gly?Asn?Thr?Gly?Met?Ala?Ala?Pro?Gln?Arg?Val?Ala?Ala?Leu?Asn

20 25 30

Arg?Pro?Asn?Met?Val?Ser?Val?Gly?Thr?Ile?Val?Phe?Leu?Ser?Gln?Glu

35 40 45

Leu?Met?Phe?Phe?Ala?Gly?Leu?Phe?Ala?Met?Tyr?Phe?Val?Ser?Arg?Ala

50 55 60

Asn?Gly?Leu?Ala?Asn?Gly?Ser?Trp?Gly?Glu?Gln?Thr?Asp?His?Leu?Asn

65 70 75 80

Val?Pro?Tyr?Ala?Leu?Leu?Ile?Thr?Val?Ile?Leu?Val?Ser?Ser?Ser?Val

85 90 95

Thr?Cys?Gln?Phe?Gly?Val?Phe?Ala?Ala?Glu?Arg?Gly?Asp?Val?Tyr?Gly

100 105 110

Leu?Arg?Lys?Trp?Phe?Leu?Val?Thr?Ile?Ile?Leu?Gly?Ser?Ile?Phe?Val

115 120 125

Ile?Gly?Gln?Gly?Tyr?Glu?Tyr?Ile?Thr?Leu?Val?Gly?His?Gly?Leu?Thr

130 135 140

Ile?Gln?Ser?Ser?Val?Tyr?Gly?Ser?Ala?Phe?Phe?Ile?Thr?Thr?Gly?Phe

145 150 155 160

His?Ala?Leu?His?Val?Ile?Ala?Gly?Val?Met?Ala?Phe?Val?Val?Val?Leu

165 170 175

Met?Arg?Ile?His?Lys?Ser?Lys?Phe?Thr?Pro?Ala?Gln?Ala?Thr?Ala?Ala

180 185 190

Met?Val?Val?Ser?Tyr?Tyr?Trp?His?Phe?Val?Asp?Val?Val?Trp?Ile?Gly

195 200 205

Leu?Phe?Ile?Thr?Ile?Tyr?Phe?Ile?Gln

210 215

<210>665

<211>1347

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1324)

<223>RXA02144

<400>665

actcactcgg?tagcttgggc?ccagtggctg?agggtctgtt?catgtgggta?ttcggcatct?60

tggtcctcgt?ggccgccgct?atgtggattg?gatcacgttc?atg?agt?aac?aac?aac 115

Met?Ser?Asn?Asn?Asn

1 5

gac?aaa?cag?tac?aca?acc?caa?gaa?ctc?aac?gcg?atg?agc?aat?gag?gat 163

Asp?Lys?Gln?Tyr?Thr?Thr?Gln?Glu?Leu?Asn?Ala?Met?Ser?Asn?Glu?Asp

10 15 20

ctt?gca?cga?ctt?ggt?aca?gag?ctg?gac?gac?gtt?acc?att?gca?tac?cgc 211

Leu?Ala?Arg?Leu?Gly?Thr?Glu?Leu?Asp?Asp?Val?Thr?Ile?Ala?Tyr?Arg

25 30 35

aag?gaa?cgt?ttc?cca?atc?gct?aat?gac?cca?gct?gag?aag?cgc?gct?gca 259

Lys?Glu?Arg?Phe?Pro?Ile?Ala?Asn?Asp?Pro?Ala?Glu?Lys?Arg?Ala?Ala

40 45 50

cgt?gca?gtt?act?ttc?tgg?cta?gtc?ctc?ggc?atc?att?ggt?gga?ctt?ggg 307

Arg?Ala?Val?Thr?Phe?Trp?Leu?Val?Leu?Gly?Ile?Ile?Gly?Gly?Leu?Gly

55 60 65

ttc?ctg?gct?acc?tac?att?ttc?tgg?cct?tgg?gag?tac?aag?gca?cac?gga 355

Phe?Leu?Ala?Thr?Tyr?Ile?Phe?Trp?Pro?Trp?Glu?Tyr?Lys?Ala?His?Gly

70 75 80 85

gat?gaa?ggt?ctc?ctg?gcg?tac?acc?ttg?tac?acc?cca?atg?ctg?ggt?att 403

Asp?Glu?Gly?Leu?Leu?Ala?Tyr?Thr?Leu?Tyr?Thr?Pro?Met?Leu?Gly?Ile

90 95 100

act?tcc?ggt?ctt?tgc?atc?ctg?tcc?ctg?gga?ttt?gca?gtt?gtc?ctt?tat 451

Thr?Ser?Gly?Leu?Cys?Ile?Leu?Ser?Leu?Gly?Phe?Ala?Val?Val?Leu?Tyr

105 110 115

gtc?aag?aag?ttc?att?cca?gag?gaa?atc?gca?gta?cag?cgt?cgc?cac?gac 499

Val?Lys?Lys?Phe?Ile?Pro?Glu?Glu?Ile?Ala?Val?Gln?Arg?Arg?His?Asp

120 125 130

ggt?cct?tct?gaa?gaa?gtt?gac?cgc?cgc?acc?atc?gtt?gca?ctt?ctc?aat 547

Gly?Pro?Ser?Glu?Glu?Val?Asp?Arg?Arg?Thr?Ile?Val?Ala?Leu?Leu?Asn

135 140 145

gac?tct?tgg?cag?acc?tct?act?ctt?ggt?cgt?cgc?aag?ctg?atc?atg?gga 595

Asp?Ser?Trp?Gln?Thr?Ser?Thr?Leu?Gly?Arg?Arg?Lys?Leu?Ile?Met?Gly

150 155 160 165

ctt?gca?ggt?ggc?gga?gca?gta?ctg?gcc?ggc?ctg?acc?atc?atc?gct?cca 643

Leu?Ala?Gly?Gly?Gly?Ala?Val?Leu?Ala?Gly?Leu?Thr?Ile?Ile?Ala?Pro

170 175 180

atg?ggc?ggt?atg?atc?aag?aac?cct?tgg?aat?cct?aag?gaa?ggc?cca?atg 691

Met?Gly?Gly?Met?Ile?Lys?Asn?Pro?Trp?Asn?Pro?Lys?Glu?Gly?Pro?Met

185 190 195

gac?gtt?cag?ggt?gac?ggc?acc?ctg?tgg?act?tcc?ggt?tgg?act?ctc?gtt 739

Asp?Val?Gln?Gly?Asp?Gly?Thr?Leu?Trp?Thr?Ser?Gly?Trp?Thr?Leu?Val

200 205 210

gag?aac?gac?gtc?aag?gtt?tac?ctc?ggc?cgc?gac?act?gca?gca?att?gcg 787

Glu?Asn?Asp?Val?Lys?Val?Tyr?Leu?Gly?Arg?Asp?Thr?Ala?Ala?Ile?Ala

215 220 225

gag?tcc?cac?acc?gat?gca?acc?ggt?gag?cac?tgg?tca?acc?act?ggt?gtt 835

Glu?Ser?His?Thr?Asp?Ala?Thr?Gly?Glu?His?Trp?Ser?Thr?Thr?Gly?Val

230 235 240 245

tcc?cgc?ctg?gtt?cgt?atg?cgc?cca?gaa?gat?ctg?gca?gca?gca?tcc?atg 883

Ser?Arg?Leu?Val?Arg?Met?Arg?Pro?Glu?Asp?Leu?Ala?Ala?Ala?Ser?Met

250 255 260

gaa?act?gtc?ttc?cca?ctt?cca?gct?gaa?atg?gtg?aac?gac?ggt?gct?gaa 931

Glu?Thr?Val?Phe?Pro?Leu?Pro?Ala?Glu?Met?Val?Asn?Asp?Gly?Ala?Glu

265 270 275

tac?gat?cct?gcg?aag?gac?gtc?tac?gag?cac?caa?atg?cac?tcg?gtg?cac 979

Tyr?Asp?Pro?Ala?Lys?Asp?Val?Tyr?Glu?His?Gln?Met?His?Ser?Val?His

280 285 290

ggc?cca?cgc?aac?gca?gtt?atg?ttg?atc?cgt?ctc?cgt?acc?gct?gac?gct 1027

Gly?Pro?Arg?Asn?Ala?Val?Met?Leu?Ile?Arg?Leu?Arg?Thr?Ala?Asp?Ala

295 300 305

gaa?aag?gtt?atc?gaa?cgc?gaa?ggc?cag?gag?tcc?ttc?cac?tac?ggt?gac 1075

Glu?Lys?Val?Ile?Glu?Arg?Glu?Gly?Gln?Glu?Ser?Phe?His?Tyr?Gly?Asp

310 315 320 325

tac?tac?gct?tac?tcc?aag?att?tgt?aca?cac?att?ggt?tgc?cca?acc?tca 1123

Tyr?Tyr?Ala?Tyr?Ser?Lys?Ile?Cys?Thr?His?Ile?Gly?Cys?Pro?Thr?Ser

330 335 340

ctg?tac?gag?gct?cag?acc?aat?cgt?att?ctg?tgc?cca?tgt?cac?cag?tcg 1171

Leu?Tyr?Glu?Ala?Gln?Thr?Asn?Arg?Ile?Leu?Cys?Pro?Cys?His?Gln?Ser

345 350 355

cag?ttt?gac?gca?ttg?cac?tac?gga?aag?cca?gtc?ttt?gga?cct?gct?gcc 1219

Gln?Phe?Asp?Ala?Leu?His?Tyr?Gly?Lys?Pro?Val?Phe?Gly?Pro?Ala?Ala

360 365 370

cgt?gca?ctg?cca?cag?ctg?cca?att?acc?gtt?gat?gaa?gag?ggc?tac?ctc 1267

Arg?Ala?Leu?Pro?Gln?Leu?Pro?Ile?Thr?Val?Asp?Glu?Glu?Gly?Tyr?Leu

375 380 385

atc?gcc?gct?ggt?aac?ttc?att?gag?cca?ctc?ggc?cct?gca?ttc?tgg?gag 1315

Ile?Ala?Ala?Gly?Asn?Phe?Ile?Glu?Pro?Leu?Gly?Pro?Ala?Phe?Trp?Glu

390 395 400 405

cgt?aag?tca?tgagtctagc?taccgtggga?aac 1347

Arg?Lys?Ser

<210>666

<211>408

<212>PRT

＜213〉Corynebacterium glutamicum

<400>666

Met?Ser?Asn?Asn?Asn?Asp?Lys?Gln?Tyr?Thr?Thr?Gln?Glu?Leu?Asn?Ala

1 5 10 15

Met?Ser?Asn?Glu?Asp?Leu?Ala?Arg?Leu?Gly?Thr?Glu?Leu?Asp?Asp?Val

20 25 30

Thr?Ile?Ala?Tyr?Arg?Lys?Glu?Arg?Phe?Pro?Ile?Ala?Asn?Asp?Pro?Ala

35 40 45

Glu?Lys?Arg?Ala?Ala?Arg?Ala?Val?Thr?Phe?Trp?Leu?Val?Leu?Gly?Ile

50 55 60

Ile?Gly?Gly?Leu?Gly?Phe?Leu?Ala?Thr?Tyr?Ile?Phe?Trp?Pro?Trp?Glu

65 70 75 80

Tyr?Lys?Ala?His?Gly?Asp?Glu?Gly?Leu?Leu?Ala?Tyr?Thr?Leu?Tyr?Thr

85 90 95

Pro?Met?Leu?Gly?Ile?Thr?Ser?Gly?Leu?Cys?Ile?Leu?Ser?Leu?Gly?Phe

100 105 110

Ala?Val?Val?Leu?Tyr?Val?Lys?Lys?Phe?Ile?Pro?Glu?Glu?Ile?Ala?Val

115 120 125

Gln?Arg?Arg?His?Asp?Gly?Pro?Ser?Glu?Glu?Val?Asp?Arg?Arg?Thr?Ile

130 135 140

Val?Ala?Leu?Leu?Asn?Asp?Ser?Trp?Gln?Thr?Ser?Thr?Leu?Gly?Arg?Arg

145 150 155 160

Lys?Leu?Ile?Met?Gly?Leu?Ala?Gly?Gly?Gly?Ala?Val?Leu?Ala?Gly?Leu

165 170 175

Thr?Ile?Ile?Ala?Pro?Met?Gly?Gly?Met?Ile?Lys?Asn?Pro?Trp?Asn?Pro

180 185 190

Lys?Glu?Gly?Pro?Met?Asp?Val?Gln?Gly?Asp?Gly?Thr?Leu?Trp?Thr?Ser

195 200 205

Gly?Trp?Thr?Leu?Val?Glu?Asn?Asp?Val?Lys?Val?Tyr?Leu?Gly?Arg?Asp

210 215 220

Thr?Ala?Ala?Ile?Ala?Glu?Ser?His?Thr?Asp?Ala?Thr?Gly?Glu?His?Trp

225 230 235 240

Ser?Thr?Thr?Gly?Val?Ser?Arg?Leu?Val?Arg?Met?Arg?Pro?Glu?Asp?Leu

245 250 255

Ala?Ala?Ala?Ser?Met?Glu?Thr?Val?Phe?Pro?Leu?Pro?Ala?Glu?Met?Val

260 265 270

Asn?Asp?Gly?Ala?Glu?Tyr?Asp?Pro?Ala?Lys?Asp?Val?Tyr?Glu?His?Gln

275 280 285

Met?His?Ser?Val?His?Gly?Pro?Arg?Asn?Ala?Val?Met?Leu?Ile?Arg?Leu

290 295 300

Arg?Thr?Ala?Asp?Ala?Glu?Lys?Val?Ile?Glu?Arg?Glu?Gly?Gln?Glu?Ser

305 310 315 320

Phe?His?Tyr?Gly?Asp?Tyr?Tyr?Ala?Tyr?Ser?Lys?Ile?Cys?Thr?His?Ile

325 330 335

Gly?Cys?Pro?Thr?Ser?Leu?Tyr?Glu?Ala?Gln?Thr?Asn?Arg?Ile?Leu?Cys

340 345 350

Pro?Cys?His?Gln?Ser?Gln?Phe?Asp?Ala?Leu?His?Tyr?Gly?Lys?Pro?Val

355 360 365

Phe?Gly?Pro?Ala?Ala?Arg?Ala?Leu?Pro?Gln?Leu?Pro?Ile?Thr?Val?Asp

370 375 380

Glu?Glu?Gly?Tyr?Leu?Ile?Ala?Ala?Gly?Asn?Phe?Ile?Glu?Pro?Leu?Gly

385 390 395 400

Pro?Ala?Phe?Trp?Glu?Arg?Lys?Ser

405

<210>667

<211>1053

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1030)

<223>RXA02740

<400>667

aacgcaaggt?gcacactcac?cgcagggata?tttaaataat?aaggactcac?aacttaaata?60

tatgagtgat?ttgaaaatgc?aacgttctgg?aggagaaccc?ttg?gac?acg?atc?aag 115

Leu?Asp?Thr?Ile?Lys

1 5

gcc?tat?att?gcg?cta?acg?aag?ccc?agg?gtt?att?gaa?ctc?ctc?ctt?gtc 163

Ala?Tyr?Ile?Ala?Leu?Thr?Lys?Pro?Arg?Val?Ile?Glu?Leu?Leu?Leu?Val

10 15 20

gcc?aca?atc?ccc?aca?atg?ctt?cag?gct?gaa?cgc?ggt?gag?aac?aac?att 211

Ala?Thr?Ile?Pro?Thr?Met?Leu?Gln?Ala?Glu?Arg?Gly?Glu?Asn?Asn?Ile

25 30 35

gtg?ctc?atc?ttg?ctg?act?gtg?ttc?ggt?ggc?tgg?atg?ggt?gcg?gcc?gcc 259

Val?Leu?Ile?Leu?Leu?Thr?Val?Phe?Gly?Gly?Trp?Met?Gly?Ala?Ala?Ala

40 45 50

gcc?aac?acc?ttc?aac?atg?gtg?gca?gac?tcc?gat?att?gat?cag?cgc?atg 307

Ala?Asn?Thr?Phe?Asn?Met?Val?Ala?Asp?Ser?Asp?Ile?Asp?Gln?Arg?Met

55 60 65

gga?cgc?act?agg?gct?cgc?cct?ttg?gtg?cgc?cac?acc?gtg?agt?aat?cgc 355

Gly?Arg?Thr?Arg?Ala?Arg?Pro?Leu?Val?Arg?His?Thr?Val?Ser?Asn?Arg

70 75 80 85

gac?gcc?tcc?att?ttt?gcg?tgg?gtc?ctg?aca?gtg?gcc?agc?ttc?ttg?tgg 403

Asp?Ala?Ser?Ile?Phe?Ala?Trp?Val?Leu?Thr?Val?Ala?Ser?Phe?Leu?Trp

90 95 100

ctg?tgg?ctg?ctg?tgc?gat?tcg?atg?ctc?gcc?ggc?atc?ttc?gtg?ttg?atc 451

Leu?Trp?Leu?Leu?Cys?Asp?Ser?Met?Leu?Ala?Gly?Ile?Phe?Val?Leu?Ile

105 110 115

acg?att?ttc?ttc?tac?att?ttt?gtc?tac?acc?aag?tgg?ctg?aag?cgc?cgc 499

Thr?Ile?Phe?Phe?Tyr?Ile?Phe?Val?Tyr?Thr?Lys?Trp?Leu?Lys?Arg?Arg

120 125 130

acg?cac?atg?aat?atc?gtg?tgg?ggc?gga?gcc?gca?ggt?tgt?atg?cca?gtg 547

Thr?His?Met?Asn?Ile?Val?Trp?Gly?Gly?Ala?Ala?Gly?Cys?Met?Pro?Val

135 140 145

ctc?gtc?ggc?tgg?gca?gtg?atc?gtt?gat?cag?ttt?gag?cca?ggc?gtt?cca 595

Leu?Val?Gly?Trp?Ala?Val?Ile?Val?Asp?Gln?Phe?Glu?Pro?Gly?Val?Pro

150 155 160 165

cag?cag?tgg?tgg?cag?gca?att?gtc?ctg?ttc?atg?gtg?att?ttc?ttc?tgg 643

Gln?Gln?Trp?Trp?Gln?Ala?Ile?Val?Leu?Phe?Met?Val?Ile?Phe?Phe?Trp

170 175 180

acc?cca?cct?cac?acc?tgg?gct?ctg?gcc?atg?aag?tac?cgc?gaa?gac?tac 691

Thr?Pro?Pro?His?Thr?Trp?Ala?Leu?Ala?Met?Lys?Tyr?Arg?Glu?Asp?Tyr

185 190 195

aag?gcg?gct?ggc?gtc?cca?atg?ctt?cct?gtc?gtg?cgc?acc?cca?gtc?cag 739

Lys?Ala?Ala?Gly?Val?Pro?Met?Leu?Pro?Val?Val?Arg?Thr?Pro?Val?Gln

200 205 210

gtc?acc?gca?caa?atc?gtg?tgg?tac?tcc?gtg?gca?act?gtg?ctg?acc?acc 787

Val?Thr?Ala?Gln?Ile?Val?Trp?Tyr?Ser?Val?Ala?Thr?Val?Leu?Thr?Thr

215 220 225

ttc?ttg?ctc?atc?cca?gca?act?ggt?tgg?atc?tac?gca?gcg?atc?gcc?gtc 835

Phe?Leu?Leu?Ile?Pro?Ala?Thr?Gly?Trp?Ile?Tyr?Ala?Ala?Ile?Ala?Val

230 235 240 245

att?tcc?ggc?gtc?acc?ttc?ttg?ttc?atg?gcc?atc?aag?ctg?cac?ctc?ggc 883

Ile?Ser?Gly?Val?Thr?Phe?Leu?Phe?Met?Ala?Ile?Lys?Leu?His?Leu?Gly

250 255 260

atc?aaa?aac?ggt?ggc?aag?gtc?aag?cct?ctg?aag?ctg?ttt?att?ttg?tcc 931

Ile?Lys?Asn?Gly?Gly?Lys?Val?Lys?Pro?Leu?Lys?Leu?Phe?Ile?Leu?Ser

265 270 275

aac?aac?tac?ttg?gca?gtc?ctc?ttc?gtg?gca?ttg?tcc?gtc?gac?gcg?gtc 979

Asn?Asn?Tyr?Leu?Ala?Val?Leu?Phe?Val?Ala?Leu?Ser?Val?Asp?Ala?Val

280 285 290

ctc?ggc?ctt?gag?acc?atc?ggc?gag?atg?ctc?ggc?tgg?acc?acc?acc?ttc 1027

Leu?Gly?Leu?Glu?Thr?Ile?Gly?Glu?Met?Leu?Gly?Trp?Thr?Thr?Thr?Phe

295 300 305

ttc?taaaagcttg?cttttcgacg?aaa 1053

Phe

310

<210>668

<211>310

<212>PRT

＜213〉Corynebacterium glutamicum

<400>668

Leu?Asp?Thr?Ile?Lys?Ala?Tyr?Ile?Ala?Leu?Thr?Lys?Pro?Arg?Val?Ile

1 5 10 15

Glu?Leu?Leu?Leu?Val?Ala?Thr?Ile?Pro?Thr?Met?Leu?Gln?Ala?Glu?Arg

20 25 30

Gly?Glu?Asn?Asn?Ile?Val?Leu?Ile?Leu?Leu?Thr?Val?Phe?Gly?Gly?Trp

35 40 45

Met?Gly?Ala?Ala?Ala?Ala?Asn?Thr?Phe?Asn?Met?Val?Ala?Asp?Ser?Asp

50 55 60

Ile?Asp?Gln?Arg?Met?Gly?Arg?Thr?Arg?Ala?Arg?Pro?Leu?Val?Arg?His

65 70 75 80

Thr?Val?Ser?Asn?Arg?Asp?Ala?Ser?Ile?Phe?Ala?Trp?Val?Leu?Thr?Val

85 90 95

Ala?Ser?Phe?Leu?Trp?Leu?Trp?Leu?Leu?Cys?Asp?Ser?Met?Leu?Ala?Gly

100 105 110

Ile?Phe?Val?Leu?Ile?Thr?Ile?Phe?Phe?Tyr?Ile?Phe?Val?Tyr?Thr?Lys

115 120 125

Trp?Leu?Lys?Arg?Arg?Thr?His?Met?Asn?Ile?Val?Trp?Gly?Gly?Ala?Ala

130 135 140

Gly?Cys?Met?Pro?Val?Leu?Val?Gly?Trp?Ala?Val?Ile?Val?Asp?Gln?Phe

145 150 155 160

Glu?Pro?Gly?Val?Pro?Gln?Gln?Trp?Trp?Gln?Ala?Ile?Val?Leu?Phe?Met

165 170 175

Val?Ile?Phe?Phe?Trp?Thr?Pro?Pro?His?Thr?Trp?Ala?Leu?Ala?Met?Lys

180 185 190

Tyr?Arg?Glu?Asp?Tyr?Lys?Ala?Ala?Gly?Val?Pro?Met?Leu?Pro?Val?Val

195 200 205

Arg?Thr?Pro?Val?Gln?Val?Thr?Ala?Gln?Ile?Val?Trp?Tyr?Ser?Val?Ala

210 215 220

Thr?Val?Leu?Thr?Thr?Phe?Leu?Leu?Ile?Pro?Ala?Thr?Gly?Trp?Ile?Tyr

225 230 235 240

Ala?Ala?Ile?Ala?Val?Ile?Ser?Gly?Val?Thr?Phe?Leu?Phe?Met?Ala?Ile

245 250 255

Lys?Leu?His?Leu?Gly?Ile?Lys?Asn?Gly?Gly?Lys?Val?Lys?Pro?Leu?Lys

260 265 270

Leu?Phe?Ile?Leu?Ser?Asn?Asn?Tyr?Leu?Ala?Val?Leu?Phe?Val?Ala?Leu

275 280 285

Ser?Val?Asp?Ala?Val?Leu?Gly?Leu?Glu?Thr?Ile?Gly?Glu?Met?Leu?Gly

290 295 300

Trp?Thr?Thr?Thr?Phe?Phe

305 310

<210>669

<211>1161

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1138)

<223>RXA02743

<400>669

atatccttaa?aagttcccgg?gagtttcagt?ggcaaatacc?accacttcca?taccgggaac?60

aattgtataa?aactagccat?gacctgctag?gatcagcgac?gtg?tct?act?tca?gat 115

Val?Ser?Thr?Ser?Asp

1 5

gct?ccc?tca?aat?aat?cca?gtt?gag?ttg?aag?ccc?att?act?ttc?tgg?gca 163

Ala?Pro?Ser?Asn?Asn?Pro?Val?Glu?Leu?Lys?Pro?Ile?Thr?Phe?Trp?Ala

10 15 20

ccg?acc?atc?aaa?gtg?cag?cgc?att?ctc?gcg?ctc?cta?ctg?ttg?att?ttc 211

Pro?Thr?Ile?Lys?Val?Gln?Arg?Ile?Leu?Ala?Leu?Leu?Leu?Leu?Ile?Phe

25 30 35

cag?gga?ggc?atc?acc?gtt?acg?ggc?tct?atc?gtc?cgt?gtc?aca?ggc?tcc 259

Gln?Gly?Gly?Ile?Thr?Val?Thr?Gly?Ser?Ile?Val?Arg?Val?Thr?Gly?Ser

40 45 50

ggc?ctc?ggt?tgt?gat?acc?tgg?cca?cta?tgc?cac?gaa?ggt?tca?cta?gtc 307

Gly?Leu?Gly?Cys?Asp?Thr?Trp?Pro?Leu?Cys?His?Glu?Gly?Ser?Leu?Val

55 60 65

cca?gtc?gca?ggc?gca?gca?cca?tgg?atc?cac?cag?gca?gtg?gaa?ttt?ggt 355

Pro?Val?Ala?Gly?Ala?Ala?Pro?Trp?Ile?His?Gln?Ala?Val?Glu?Phe?Gly

70 75 80 85

aac?cgc?atg?ctc?act?ttc?gtg?ctt?gct?gcc?gca?gcg?ctt?gcg?ttg?ttc 403

Asn?Arg?Met?Leu?Thr?Phe?Val?Leu?Ala?Ala?Ala?Ala?Leu?Ala?Leu?Phe

90 95 100

att?gca?gtt?ctt?ggc?gca?aaa?cgc?cgc?cgc?gag?atc?ctg?gtc?cat?tcc 451

Ile?Ala?Val?Leu?Gly?Ala?Lys?Arg?Arg?Arg?Glu?Ile?Leu?Val?His?Ser

105 110 115

ttc?atc?cag?ggt?ttg?ggc?atc?atc?ttg?cag?gct?gtc?atc?ggt?ggc?atc 499

Phe?Ile?Gln?Gly?Leu?Gly?Ile?Ile?Leu?Gln?Ala?Val?Ile?Gly?Gly?Ile

120 125 130

acc?gtg?ctg?gtt?gat?ttg?cac?tgg?tac?gcc?gtt?gct?ttg?cac?ttc?ctg 547

Thr?Val?Leu?Val?Asp?Leu?His?Trp?Tyr?Ala?Val?Ala?Leu?His?Phe?Leu

135 140 145

cca?tcc?atg?atc?ctt?gtt?ttc?atg?gcc?gcg?att?ttg?tac?acc?cgc?atc 595

Pro?Ser?Met?Ile?Leu?Val?Phe?Met?Ala?Ala?Ile?Leu?Tyr?Thr?Arg?Ile

150 155 160 165

ggc?gag?ccc?gat?gac?ggc?gag?att?acc?acc?aca?ttc?ccc?acg?tgg?atc 643

Gly?Glu?Pro?Asp?Asp?Gly?Glu?Ile?Thr?Thr?Thr?Phe?Pro?Thr?Trp?Ile

170 175 180

cgc?aat?gta?gct?gtc?att?ggt?gca?gta?gcg?ctc?tcc?gta?gta?ctg?atc 691

Arg?Asn?Val?Ala?Val?Ile?Gly?Ala?Val?Ala?Leu?Ser?Val?Val?Leu?Ile

185 190 195

acc?ggc?acc?atg?acc?acc?ggc?gct?ggc?gtt?cac?tct?ggc?gat?gca?tca 739

Thr?Gly?Thr?Met?Thr?Thr?Gly?Ala?Gly?Val?His?Ser?Gly?Asp?Ala?Ser

200 205 210

atc?acc?atg?gat?gat?cgc?ctc?gat?gtc?agc?atc?gac?ttg?atg?gcc?cac 787

Ile?Thr?Met?Asp?Asp?Arg?Leu?Asp?Val?Ser?Ile?Asp?Leu?Met?Ala?His

215 220 225

atc?cac?ggc?tac?agc?atg?tac?atc?tac?ctc?ttc?ttc?acc?ctc?atc?gtg 835

Ile?His?Gly?Tyr?Ser?Met?Tyr?Ile?Tyr?Leu?Phe?Phe?Thr?Leu?Ile?Val

230 235 240 245

gtc?gcc?ggt?ctg?tac?aag?gca?aaa?acc?acc?aag?cac?aac?aag?cag?ctt 883

Val?Ala?Gly?Leu?Tyr?Lys?Ala?Lys?Thr?Thr?Lys?His?Asn?Lys?Gln?Leu

250 255 260

ggc?ctc?atg?ctg?att?ctg?ttc?att?ctg?att?cag?gca?ggt?atc?ggc?atc 931

Gly?Leu?Met?Leu?Ile?Leu?Phe?Ile?Leu?Ile?Gln?Ala?Gly?Ile?Gly?Ile

265 270 275

ttg?cag?tac?cgc?atg?ggt?gtg?cca?cgc?tgg?agc?atc?cca?ttc?cac?atc 979

Leu?Gln?Tyr?Arg?Met?Gly?Val?Pro?Arg?Trp?Ser?Ile?Pro?Phe?His?Ile

280 285 290

gca?atg?tct?tct?gtc?gtt?gtt?gcc?ttc?act?tcc?ctt?ctg?tgg?gcg?cag 1027

Ala?Met?Ser?Ser?Val?Val?Val?Ala?Phe?Thr?Ser?Leu?Leu?Trp?Ala?Gln

295 300 305

ggt?cgt?ata?cgc?gtc?ggc?ggt?aaa?gcc?acc?gtt?act?ggt?tct?gtt?gat 1075

Gly?Arg?Ile?Arg?Val?Gly?Gly?Lys?Ala?Thr?Val?Thr?Gly?Ser?Val?Asp

310 315 320 325

ggc?gat?att?aag?aac?gag?atc?att?acg?aac?ccc?ttt?gag?aag?aaa?tca 1123

Gly?Asp?Ile?Lys?Asn?Glu?Ile?Ile?Thr?Asn?Pro?Phe?Glu?Lys?Lys?Ser

330 335 340

aag?cag?cct?gtt?aaa?taacacgcaa?ctgtatcggt?aaa 1161

Lys?Gln?Pro?Val?Lys

345

<210>670

<211>346

<212>PRT

＜213〉Corynebacterium glutamicum

<400>670

Val?Ser?Thr?Ser?Asp?Ala?Pro?Ser?Asn?Asn?Pro?Val?Glu?Leu?Lys?Pro

1 5 10 15

Ile?Thr?Phe?Trp?Ala?Pro?Thr?Ile?Lys?Val?Gln?Arg?Ile?Leu?Ala?Leu

20 25 30

Leu?Leu?Leu?Ile?Phe?Gln?Gly?Gly?Ile?Thr?Val?Thr?Gly?Ser?Ile?Val

35 40 45

Arg?Val?Thr?Gly?Ser?Gly?Leu?Gly?Cys?Asp?Thr?Trp?Pro?Leu?Cys?His

50 55 60

Glu?Gly?Ser?Leu?Val?Pro?Val?Ala?Gly?Ala?Ala?Pro?Trp?Ile?His?Gln

65 70 75 80

Ala?Val?Glu?Phe?Gly?Asn?Arg?Met?Leu?Thr?Phe?Val?Leu?Ala?Ala?Ala

85 90 95

Ala?Leu?Ala?Leu?Phe?Ile?Ala?Val?Leu?Gly?Ala?Lys?Arg?Arg?Arg?Glu

100 105 110

Ile?Leu?Val?His?Ser?Phe?Ile?Gln?Gly?Leu?Gly?Ile?Ile?Leu?Gln?Ala

115 120 125

Val?Ile?Gly?Gly?Ile?Thr?Val?Leu?Val?Asp?Leu?His?Trp?Tyr?Ala?Val

130 135 140

Ala?Leu?His?Phe?Leu?Pro?Ser?Met?Ile?Leu?Val?Phe?Met?Ala?Ala?Ile

145 150 155 160

Leu?Tyr?Thr?Arg?Ile?Gly?Glu?Pro?Asp?Asp?Gly?Glu?Ile?Thr?Thr?Thr

165 170 175

Phe?Pro?Thr?Trp?Ile?Arg?Asn?Val?Ala?Val?Ile?Gly?Ala?Val?Ala?Leu

180 185 190

Ser?Val?Val?Leu?Ile?Thr?Gly?Thr?Met?Thr?Thr?Gly?Ala?Gly?Val?His

195 200 205

Ser?Gly?Asp?Ala?Ser?Ile?Thr?Met?Asp?Asp?Arg?Leu?Asp?Val?Ser?Ile

210 215 220

Asp?Leu?Met?Ala?His?Ile?His?Gly?Tyr?Ser?Met?Tyr?Ile?Tyr?Leu?Phe

225 230 235 240

Phe?Thr?Leu?Ile?Val?Val?Ala?Gly?Leu?Tyr?Lys?Ala?Lys?Thr?Thr?Lys

245 250 255

His?Asn?Lys?Gln?Leu?Gly?Leu?Met?Leu?Ile?Leu?Phe?Ile?Leu?Ile?Gln

260 265 270

Ala?Gly?Ile?Gly?Ile?Leu?Gln?Tyr?Arg?Met?Gly?Val?Pro?Arg?Trp?Ser

275 280 285

Ile?Pro?Phe?His?Ile?Ala?Met?Ser?Ser?Val?Val?Val?Ala?Phe?Thr?Ser

290 295 300

Leu?Leu?Trp?Ala?Gln?Gly?Arg?Ile?Arg?Val?Gly?Gly?Lys?Ala?Thr?Val

305 310 315 320

Thr?Gly?Ser?Val?Asp?Gly?Asp?Ile?Lys?Asn?Glu?Ile?Ile?Thr?Asn?Pro

325 330 335

Phe?Glu?Lys?Lys?Ser?Lys?Gln?Pro?Val?Lys

340 345

<210>671

<211>444

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..?(421)

<223>RXA01227

<400>671

ggataatcga?aaatatgtgc?cccttggtga?agggtcgggg?agctaatagg?atgacagtga?60

acctattttc?cacgtcttta?tccgtagtat?tggagatccg?atg?acc?tac?aca?atc 115

Met?Thr?Tyr?Thr?Ile

1 5

gcc?cag?ccc?tgc?gtt?gat?gtc?ctg?gat?cga?gcc?tgc?gtc?gag?gaa?tgt 163

Ala?Gln?Pro?Cys?Val?Asp?Val?Leu?Asp?Arg?Ala?Cys?Val?Glu?Glu?Cys

10 15 20

ccc?gtg?gac?tgc?atc?tac?gag?ggc?aaa?cgg?atg?ctc?tac?atc?cac?ccc 211

Pro?Val?Asp?Cys?Ile?Tyr?Glu?Gly?Lys?Arg?Met?Leu?Tyr?Ile?His?Pro

25 30 35

gat?gag?tgc?gtc?gac?tgc?ggt?gcc?tgc?gag?ccc?gtc?tgc?ccg?gtt?gaa 259

Asp?Glu?Cys?Val?Asp?Cys?Gly?Ala?Cys?Glu?Pro?Val?Cys?Pro?Val?Glu

40 45 50

gcc?atc?ttc?tac?gaa?gat?gat?gtt?ccc?cac?gaa?tgg?tgg?gac?tac?acc 307

Ala?Ile?Phe?Tyr?Glu?Asp?Asp?Val?Pro?His?Glu?Trp?Trp?Asp?Tyr?Thr

55 60 65

ggc?gct?aac?gcc?gcc?ttt?ttc?gac?gac?ctc?ggt?tcg?cca?ggc?ggt?gcc 355

Gly?Ala?Asn?Ala?Ala?Phe?Phe?Asp?Asp?Leu?Gly?Ser?Pro?Gly?Gly?Ala

70 75 80 85

gcc?agc?ctg?ggt?ccg?cag?gac?ttc?gac?gcc?cag?ctc?gtc?gcg?gtg?ctg 403

Ala?Ser?Leu?Gly?Pro?Gln?Asp?Phe?Asp?Ala?Gln?Leu?Val?Ala?Val?Leu

90 95 100

ccg?cca?cag?aac?cag?aac?taggacctga?tatcggccct?aaa 444

Pro?Pro?Gln?Asn?Gln?Asn

105

<210>672

<211>107

<212>PRT

＜213〉Corynebacterium glutamicum

<400>672

Met?Thr?Tyr?Thr?Ile?Ala?Gln?Pro?Cys?Val?Asp?Val?Leu?Asp?Arg?Ala

1 5 10 15

Cys?Val?Glu?Glu?Cys?Pro?Val?Asp?Cys?Ile?Tyr?Glu?Gly?Lys?Arg?Met

20 25 30

Leu?Tyr?Ile?His?Pro?Asp?Glu?Cys?Val?Asp?Cys?Gly?Ala?Cys?Glu?Pro

35 40 45

Val?Cys?Pro?Val?Glu?Ala?Ile?Phe?Tyr?Glu?Asp?Asp?Val?Pro?His?Glu

50 55 60

Trp?Trp?Asp?Tyr?Thr?Gly?Ala?Asn?Ala?Ala?Phe?Phe?Asp?Asp?Leu?Gly

65 70 75 80

Ser?Pro?Gly?Gly?Ala?Ala?Ser?Leu?Gly?Pro?Gln?Asp?Phe?Asp?Ala?Gln

85 90 95

Leu?Val?Ala?Val?Leu?Pro?Pro?Gln?Asn?Gln?Asn

100 105

<210>673

<211>438

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..?(415)

<223>RXA01865

<400>673

ggtggaattt?ggcctgcggt?caaggggaag?tagcataata?agcctaaagc?tttcccatat?60

ttattagcct?cttagagttc?tcaggagaaa?acgaaatccc?atg?aca?tac?aca?atc 115

Met?Thr?Tyr?Thr?Ile

1 5

gca?cag?ccc?tgc?gtt?gac?gtc?ttg?gat?cgt?gcc?tgc?gtt?gaa?gaa?tgc 163

Ala?Gln?Pro?Cys?Val?Asp?Val?Leu?Asp?Arg?Ala?Cys?Val?Glu?Glu?Cys

10 15 20

cca?gta?gat?tgc?atc?tac?gaa?ggt?aag?cgc?atg?ctg?tac?atc?cac?ccg 211

Pro?Val?Asp?Cys?Ile?Tyr?Glu?Gly?Lys?Arg?Met?Leu?Tyr?Ile?His?Pro

25 30 35

gat?gag?tgc?gtt?gac?tgt?ggt?gca?tgt?gag?cct?gct?tgc?cca?gtt?gag 259

Asp?Glu?Cys?Val?Asp?Cys?Gly?Ala?Cys?Glu?Pro?Ala?Cys?Pro?Val?Glu

40 45 50

gca?atc?ttc?tac?gag?gac?gat?gtc?cca?gac?gaa?tgg?ctt?gac?tac?aac 307

Ala?Ile?Phe?Tyr?Glu?Asp?Asp?Val?Pro?Asp?Glu?Trp?Leu?Asp?Tyr?Ash

55 60 65

gat?gcc?aac?gct?gca?ttc?ttc?gat?gat?ctg?ggc?tcc?cca?ggt?ggt?gcg 355

Asp?Ala?Asn?Ala?Ala?Phe?Phe?Asp?Asp?Leu?Gly?Ser?Pro?Gly?Gly?Ala

70 75 80 85

gct?aag?ctt?gga?cca?caa?gat?ttt?gat?cac?cca?atg?atc?gct?gcg?ctg 403

Ala?Lys?Leu?Gly?Pro?Gln?Asp?Phe?Asp?His?Pro?Met?Ile?Ala?Ala?Leu

90 95 100

ccg?cct?cag?gca?taatctaacg?catgacctct?cgc 438

Pro?Pro?Gln?Ala

105

<210>674

<211>105

<212>PRT

＜213〉Corynebacterium glutamicum

<400>674

Met?Thr?Tyr?Thr?Ile?Ala?Gln?Pro?Cys?Val?Asp?Val?Leu?Asp?Arg?Ala

1 5 10 15

Cys?Val?Glu?Glu?Cys?Pro?Val?Asp?Cys?Ile?Tyr?Glu?Gly?Lys?Arg?Met

20 25 30

Leu?Tyr?Ile?His?Pro?Asp?Glu?Cys?Val?Asp?Cys?Gly?Ala?Cys?Glu?Pro

35 40 45

Ala?Cys?Pro?Val?Glu?Ala?Ile?Phe?Tyr?Glu?Asp?Asp?Val?Pro?Asp?Glu

50 55 60

Trp?Leu?Asp?Tyr?Asn?Asp?Ala?Asn?Ala?Ala?Phe?Phe?Asp?Asp?Leu?Gly

65 70 75 80

Ser?Pro?Gly?Gly?Ala?Ala?Lys?Leu?Gly?Pro?Gln?Asp?Phe?Asp?His?Pro

85 90 95

Met?Ile?Ala?Ala?Leu?Pro?Pro?Gln?Ala

100 105

<210>675

<211>441

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(418)

<223>RXA00680

<400>675

ttcttgcatc?cccagaagcc?gaatacatca?ctgggcaaac?actcatcgtt?gatggtggcc?60

gacagttcat?ctaagtacta?aaagttctaa?ggagaagatc?atg?tct?act?att?cat 115

Met?Ser?Thr?Ile?His

1 5

ttc?att?gat?cat?gct?ggc?aaa?acc?cgc?acc?atc?gag?gcg?act?gtt?ggt 163

Phe?Ile?Asp?His?Ala?Gly?Lys?Thr?Arg?Thr?Ile?Glu?Ala?Thr?Val?Gly

10 15 20

gat?tca?gta?atg?gag?acc?gca?gtc?cga?aac?gga?gtg?cct?gga?att?gtt 211

Asp?Ser?Val?Met?Glu?Thr?Ala?Val?Arg?Asn?Gly?Val?Pro?Gly?Ile?Val

25 30 35

gct?gaa?tgc?ggc?ggt?tcc?tta?tcg?tgt?gca?acc?tgc?cat?gtg?ttt?gtt 259

Ala?Glu?Cys?Gly?Gly?Ser?Leu?Ser?Cys?Ala?Thr?Cys?His?Val?Phe?Val

40 45 50

gac?cct?gca?cag?tat?gat?gcg?ctt?ccc?cca?atg?gag?gag?atg?gaa?gat 307

Asp?Pro?Ala?Gln?Tyr?Asp?Ala?Leu?Pro?Pro?Met?Glu?Glu?Met?Glu?Asp

55 60 65

gaa?atg?ctg?tgg?ggt?gct?gcc?gtg?gac?cgt?gag?gat?tgc?tcc?cgt?ttg 355

Glu?Met?Leu?Trp?Gly?Ala?Ala?Val?Asp?Arg?Glu?Asp?Cys?Ser?Arg?Leu

70 75 80 85

tct?tgc?caa?atc?aag?gtc?acc?gaa?ggc?atg?gat?ctt?tcg?ttg?acc?acg 403

Ser?Cys?Gln?Ile?Lys?Val?Thr?Glu?Gly?Met?Asp?Leu?Ser?Leu?Thr?Thr

90 95 100

cca?gaa?acg?caa?gtg?tgaggttgaa?tcatgaatac?ttc 441

Pro?Glu?Thr?Gln?Val

105

<210>676

<211>106

<212>PRT

＜213〉Corynebacterium glutamicum

<400>676

Met?Ser?Thr?Ile?His?Phe?Ile?Asp?His?Ala?Gly?Lys?Thr?Arg?Thr?Ile

1 5 10 15

Glu?Ala?Thr?Val?Gly?Asp?Ser?Val?Met?Glu?Thr?Ala?Val?Arg?Asn?Gly

20 25 30

Val?Pro?Gly?Ile?Val?Ala?Glu?Cys?Gly?Gly?Ser?Leu?Ser?Cys?Ala?Thr

35 40 45

Cys?His?Val?Phe?Val?Asp?Pro?Ala?Gln?Tyr?Asp?Ala?Leu?Pro?Pro?Met

50 55 60

Glu?Glu?Met?Glu?Asp?Glu?Met?Leu?Trp?Gly?Ala?Ala?Val?Asp?Arg?Glu

65 70 75 80

Asp?Cys?Ser?Arg?Leu?Ser?Cys?Gln?Ile?Lys?Val?Thr?Glu?Gly?Met?Asp

85 90 95

Leu?Ser?Leu?Thr?Thr?Pro?Glu?Thr?Gln?Val

100 105

<210>677

<211>1389

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1366)

<223>RXA00679

<400>677

ggaccgtgag?gattgctccc?gtttgtcttg?ccaaatcaag?gtcaccgaag?gcatggatct?60

ttcgttgacc?acgccagaaa?cgcaagtgtg?aggttgaatc?atg?aat?act?tca?gct 115

Met?Asn?Thr?Ser?Ala

1 5

gaa?act?gga?atc?ttg?atc?atc?ggt?gca?aac?caa?tcg?ggt?gtg?cag?ctg 163

Glu?Thr?Gly?Ile?Leu?Ile?Ile?Gly?Ala?Asn?Gln?Ser?Gly?Val?Gln?Leu

10 15 20

gcg?att?tcc?ctg?cgg?gcc?acg?ggt?ttc?acc?gaa?tcg?atc?acg?ctt?cta 211

Ala?Ile?Ser?Leu?Arg?Ala?Thr?Gly?Phe?Thr?Glu?Ser?Ile?Thr?Leu?Leu

25 30 35

ggc?gag?gag?gat?cac?cgc?ccc?tac?cag?cgt?ccc?gcc?ttg?tcc?aag?gag 259

Gly?Glu?Glu?Asp?His?Arg?Pro?Tyr?Gln?Arg?Pro?Ala?Leu?Ser?Lys?Glu

40 45 50

ttc?ctc?cag?gac?aag?atc?gac?aaa?gag?cgt?ctg?att?ttc?cgt?tcc?aat 307

Phe?Leu?Gln?Asp?Lys?Ile?Asp?Lys?Glu?Arg?Leu?Ile?Phe?Arg?Ser?Asn

55 60 65

gag?tat?tgg?gaa?gaa?aat?aat?att?cgc?ctg?gtc?aag?ggc?gtg?cgc?atc 355

Glu?Tyr?Trp?Glu?Glu?Asn?Asn?Ile?Arg?Leu?Val?Lys?Gly?Val?Arg?Ile

70 75 80 85

gaa?cgc?att?gaa?aag?aac?gac?gac?gga?tca?ggg?gtc?gcc?tac?ggc?gcc 403

Glu?Arg?Ile?Glu?Lys?Asn?Asp?Asp?Gly?Ser?Gly?Val?Ala?Tyr?Gly?Ala

90 95 100

gga?caa?gaa?ttc?gct?ttt?cga?cgt?ctc?gct?cta?gcg?gtt?ggt?gcc?cgc 451

Gly?Gln?Glu?Phe?Ala?Phe?Arg?Arg?Leu?Ala?Leu?Ala?Val?Gly?Ala?Arg

105 110 115

cct?cgc?cac?ctc?gac?ctc?ccg?ggc?gcc?acc?ttg?gag?ggt?gtc?acc?tac 499

Pro?Arg?His?Leu?Asp?Leu?Pro?Gly?Ala?Thr?Leu?Glu?Gly?Val?Thr?Tyr

120 125 130

ctg?cgc?aac?gcg?gac?gac?gcc?ttg?gcg?ctc?aaa?gcg?atg?att?ggt?tct 547

Leu?Arg?Asn?Ala?Asp?Asp?Ala?Leu?Ala?Leu?Lys?Ala?Met?Ile?Gly?Ser

135 140 145

gtc?acc?gat?gcc?gtt?gta?gtc?ggt?ggt?ggg?ttc?atc?gga?ttg?gaa?gct 595

Val?Thr?Asp?Ala?Val?Val?Val?Gly?Gly?Gly?Phe?Ile?Gly?Leu?Glu?Ala

150 155 160 165

gcg?tgt?tcg?ctt?cat?gac?ctc?ggc?aaa?aat?gtc?acc?gtc?ctg?gaa?tat 643

Ala?Cys?Ser?Leu?His?Asp?Leu?Gly?Lys?Asn?Val?Thr?Val?Leu?Glu?Tyr

170 175 180

ggt?ccg?cgt?ctg?att?ggc?cga?gcg?gtg?ggt?gaa?gaa?acc?gca?gca?ttc 691

Gly?Pro?Arg?Leu?Ile?Gly?Arg?Ala?Val?Gly?Glu?Glu?Thr?Ala?Ala?Phe

185 190 195

ttc?ctc?gaa?caa?cac?cgt?tcc?cgt?ggc?gta?aat?atc?gtg?ctt?gat?gcc 739

Phe?Leu?Glu?Gln?His?Arg?Ser?Arg?Gly?Val?Asn?Ile?Val?Leu?Asp?Ala

200 205 210

cgc?atg?aaa?cag?ttt?gtg?ggc?aag?gat?gga?aag?ctc?agc?ggc?att?gag 787

Arg?Met?Lys?Gln?Phe?Val?Gly?Lys?Asp?Gly?Lys?Leu?Ser?Gly?Ile?Glu

215 220 225

cta?gaa?gat?ggc?aca?gta?att?cct?gcc?caa?cta?gtc?att?gtg?ggc?atc 835

Leu?Glu?Asp?Gly?Thr?Val?Ile?Pro?Ala?Gln?Leu?Val?Ile?Val?Gly?Ile

230 235 240 245

ggt?gtc?att?ccg?aac?aca?gaa?ctt?gcc?gct?gtt?ctg?ggc?tta?gac?atc 883

Gly?Val?Ile?Pro?Asn?Thr?Glu?Leu?Ala?Ala?Val?Leu?Gly?Leu?Asp?Ile

250 255 260

aac?aac?ggc?atc?gtg?gtg?gat?aaa?cat?gcc?gtc?gcg?tca?gat?ggc?acc 931

Asn?Asn?Gly?Ile?Val?Val?Asp?Lys?His?Ala?Val?Ala?Ser?Asp?Gly?Thr

265 270 275

acc?att?gcg?att?ggc?gat?gtc?gcc?aac?att?ccc?aat?cca?atc?cct?ggt 979

Thr?Ile?Ala?Ile?Gly?Asp?Val?Ala?Asn?Ile?Pro?Asn?Pro?Ile?Pro?Gly

280 285 290

tcc?ccc?gct?gat?gaa?cgc?atc?cga?cta?gaa?agc?gtc?aat?aac?gcc?atc 1027

Ser?Pro?Ala?Asp?Glu?Arg?Ile?Arg?Leu?Glu?Ser?Val?Asn?Asn?Ala?Ile

295 300 305

gag?cac?gca?aag?atc?gct?gca?tac?tca?ctc?gtc?ggc?cag?ccc?gaa?gcc 1075

Glu?His?Ala?Lys?Ile?Ala?Ala?Tyr?Ser?Leu?Val?Gly?Gln?Pro?Glu?Ala

310 315 320 325

tac?gcc?gga?atc?ccc?tgg?ttc?tgg?tcc?aac?caa?ggc?gat?ctc?aaa?cta 1123

Tyr?Ala?Gly?Ile?Pro?Trp?Phe?Trp?Ser?Asn?Gln?Gly?Asp?Leu?Lys?Leu

330 335 340

caa?att?gca?gga?ctt?acc?ctt?ggt?tat?gac?agc?aca?gta?atc?cga?cag 1171

Gln?Ile?Ala?Gly?Leu?Thr?Leu?Gly?Tyr?Asp?Ser?Thr?Val?Ile?Arg?Gln

345 350 355

gat?ccc?gag?aaa?aag?aag?ttc?tct?gtc?ctt?tat?tac?cgt?ggc?gac?aac 1219

Asp?Pro?Glu?Lys?Lys?Lys?Phe?Ser?Val?Leu?Tyr?Tyr?Arg?Gly?Asp?Asn

360 365 370

atc?atc?gcc?gcc?gat?tgt?gtc?aac?gct?cca?ctg?gat?ttc?atg?gct?gtg 1267

Ile?Ile?Ala?Ala?Asp?Cys?Val?Asn?Ala?Pro?Leu?Asp?Phe?Met?Ala?Val

375 380 385

cgc?agt?gca?ctt?tcc?agg?aac?caa?aat?atc?ccc?gcc?gac?ctt?gct?gca 1315

Arg?Ser?Ala?Leu?Ser?Arg?Asn?Gln?Asn?Ile?Pro?Ala?Asp?Leu?Ala?Ala

390 395 400 405

gat?att?tcg?cag?ccg?ctg?aaa?aaa?cta?gcc?gtt?gac?ctg?gag?gtt?acc 1363

Asp?Ile?Ser?Gln?Pro?Leu?Lys?Lys?Leu?Ala?Val?Asp?Leu?Glu?Val?Thr

410 415 420

cga?tgactcgcag?taatttaccc?gct 1389

Arg

<210>678

<211>422

<212>PRT

＜213〉Corynebacterium glutamicum

<400>678

Met?Asn?Thr?Ser?Ala?Glu?Thr?Gly?Ile?Leu?Ile?Ile?Gly?Ala?Asn?Gln

1 5 10 15

Ser?Gly?Val?Gln?Leu?Ala?Ile?Ser?Leu?Arg?Ala?Thr?Gly?Phe?Thr?Glu

20 25 30

Ser?Ile?Thr?Leu?Leu?Gly?Glu?Glu?Asp?His?Arg?Pro?Tyr?Gln?Arg?Pro

35 40 45

Ala?Leu?Ser?Lys?Glu?Phe?Leu?Gln?Asp?Lys?Ile?Asp?Lys?Glu?Arg?Leu

50 55 60

Ile?Phe?Arg?Ser?Asn?Glu?Tyr?Trp?Glu?Glu?Asn?Asn?Ile?Arg?Leu?Val

65 70 75 80

Lys?Gly?Val?Arg?Ile?Glu?Arg?Ile?Glu?Lys?Asn?Asp?Asp?Gly?Ser?Gly

85 90 95

Val?Ala?Tyr?Gly?Ala?Gly?Gln?Glu?Phe?Ala?Phe?Arg?Arg?Leu?Ala?Leu

100 105 110

Ala?Val?Gly?Ala?Arg?Pro?Arg?His?Leu?Asp?Leu?Pro?Gly?Ala?Thr?Leu

115 120 125

Glu?Gly?Val?Thr?Tyr?Leu?Arg?Asn?Ala?Asp?Asp?Ala?Leu?Ala?Leu?Lys

130 135 140

Ala?Met?Ile?Gly?Ser?Val?Thr?Asp?Ala?Val?Val?Val?Gly?Gly?Gly?Phe

145 150 155 160

Ile?Gly?Leu?Glu?Ala?Ala?Cys?Ser?Leu?His?Asp?Leu?Gly?Lys?Asn?Val

165 170 175

Thr?Val?Leu?Glu?Tyr?Gly?Pro?Arg?Leu?Ile?Gly?Arg?Ala?Val?Gly?Glu

180 185 190

Glu?Thr?Ala?Ala?Phe?Phe?Leu?Glu?Gln?His?Arg?Ser?Arg?Gly?Val?Asn

195 200 205

Ile?Val?Leu?Asp?Ala?Arg?Met?Lys?Gln?Phe?Val?Gly?Lys?Asp?Gly?Lys

210 215 220

Leu?Ser?Gly?Ile?Glu?Leu?Glu?Asp?Gly?Thr?Val?Ile?Pro?Ala?Gln?Leu

225 230 235 240

Val?Ile?Val?Gly?Ile?Gly?Val?Ile?Pro?Asn?Thr?Glu?Leu?Ala?Ala?Val

245 250 255

Leu?Gly?Leu?Asp?Ile?Asn?Asn?Gly?Ile?Val?Val?Asp?Lys?His?Ala?Val

260 265 270

Ala?Ser?Asp?Gly?Thr?Thr?Ile?Ala?Ile?Gly?Asp?Val?Ala?Asn?Ile?Pro

275 280 285

Asn?Pro?Ile?Pro?Gly?Ser?Pro?Ala?Asp?Glu?Arg?Ile?Arg?Leu?Glu?Ser

290 295 300

Val?Asn?Asn?Ala?Ile?Glu?His?Ala?Lys?Ile?Ala?Ala?Tyr?Ser?Leu?Val

305 310 315 320

Gly?Gln?Pro?Glu?Ala?Tyr?Ala?Gly?Ile?Pro?Trp?Phe?Trp?Ser?Asn?Gln

325 330 335

Gly?Asp?Leu?Lys?Leu?Gln?Ile?Ala?Gly?Leu?Thr?Leu?Gly?Tyr?Asp?Ser

340 345 350

Thr?Val?Ile?Arg?Gln?Asp?Pro?Glu?Lys?Lys?Lys?Phe?Ser?Val?Leu?Tyr

355 360 365

Tyr?Arg?Gly?Asp?Asn?Ile?Ile?Ala?Ala?Asp?Cys?Val?Asn?Ala?Pro?Leu

370 375 380

Asp?Phe?Met?Ala?Val?Arg?Ser?Ala?Leu?Ser?Arg?Asn?Gln?Asn?Ile?Pro

385 390 395 400

Ala?Asp?Leu?Ala?Ala?Asp?Ile?Ser?Gln?Pro?Leu?Lys?Lys?Leu?Ala?Val

405 410 415

Asp?Leu?Glu?Val?Thr?Arg

420

<210>679

<211>1074

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1051)

<223>RXA00224

<400>679

gtgatgtcat?tggtgcatcg?ggtgctgctg?aaaagattgc?tgagtacctc?gcttcagaga?60

acctcatcta?gccactatct?tcacaaagga?gaacatttaa?atg?tct?att?tct?tat 115

Met?Ser?Ile?Ser?Tyr

1 5

gtg?ctg?gtt?gag?cag?cta?gat?ggc?cgc?cca?gaa?cca?gtt?acc?ctt?gaa 163

Val?Leu?Val?Glu?Gln?Leu?Asp?Gly?Arg?Pro?Glu?Pro?Val?Thr?Leu?Glu

10 15 20

ttg?atc?act?gct?gct?cgc?gca?ctc?ggt?gac?gtc?gtt?gcc?gtt?gtc?gtt 211

Leu?Ile?Thr?Ala?Ala?Arg?Ala?Leu?Gly?Asp?Val?Val?Ala?Val?Val?Val

25 30 35

ggc?gag?cca?ggt?gcc?ggc?gta?aac?ctt?gct?gct?gag?ctc?ggc?aat?tgg 259

Gly?Glu?Pro?Gly?Ala?Gly?Val?Asn?Leu?Ala?Ala?Glu?Leu?Gly?Asn?Trp

40 45 50

ggt?gca?gca?cag?gtt?gtt?tcc?gct?gaa?atc?tct?ggc?gct?tcc?aac?cgt 307

Gly?Ala?Ala?Gln?Val?Val?Ser?Ala?Glu?Ile?Ser?Gly?Ala?Ser?Asn?Arg

55 60 65

ttg?atc?ttg?cct?gct?gtt?gat?gcg?ctg?cac?att?ttg?gct?gcg?aac?aac 355

Leu?Ile?Leu?Pro?Ala?Val?Asp?Ala?Leu?His?Ile?Leu?Ala?Ala?Asn?Asn

70 75 80 85

cca?ggt?cca?att?gtt?atc?gct?gca?act?gca?agc?ggt?aat?gag?atc?gct 403

Pro?Gly?Pro?Ile?Val?Ile?Ala?Ala?Thr?Ala?Ser?Gly?Asn?Glu?Ile?Ala

90 95 100

ggt?cgt?ttg?gct?gcc?cgt?ttg?gct?tct?ggt?gtg?ctc?acc?gat?gtc?gtc 451

Gly?Arg?Leu?Ala?Ala?Arg?Leu?Ala?Ser?Gly?Val?Leu?Thr?Asp?Val?Val

105 110 115

gga?atc?aat?gcc?gac?cgc?acc?gca?cag?cag?tcc?att?ttc?ggc?gac?acc 499

Gly?Ile?Asn?Ala?Asp?Arg?Thr?Ala?Gln?Gln?Ser?Ile?Phe?Gly?Asp?Thr

120 125 130

att?cag?gtg?tcc?gct?gca?gtt?ggt?ggc?gct?tca?ccg?ctg?tac?acc?ctg 547

Ile?Gln?Val?Ser?Ala?Ala?Val?Gly?Gly?Ala?Ser?Pro?Leu?Tyr?Thr?Leu

135 140 145

cgt?cca?ggt?gcc?ctt?gat?ggc?gtg?gcc?gtt?cct?gca?acc?ggt?gaa?ttg 595

Arg?Pro?Gly?Ala?Leu?Asp?Gly?Val?Ala?Val?Pro?Ala?Thr?Gly?Glu?Leu

150 155 160 165

gca?acc?att?gag?atc?cca?ggc?gca?acc?gcc?aag?gat?gtc?acc?atc?acc 643

Ala?Thr?Ile?Glu?Ile?Pro?Gly?Ala?Thr?Ala?Lys?Asp?Val?Thr?Ile?Thr

170 175 180

tcc?ttc?acg?cca?agc?acc?cag?agc?gat?cgc?cct?gag?ctg?cca?cag?gca 691

Ser?Phe?Thr?Pro?Ser?Thr?Gln?Ser?Asp?Arg?Pro?Glu?Leu?Pro?Gln?Ala

185 190 195

aag?gtc?gtt?atc?gca?ggt?gga?cgt?ggt?gtc?gga?agc?gaa?gaa?aac?ttc 739

Lys?Val?Val?Ile?Ala?Gly?Gly?Arg?Gly?Val?Gly?Ser?Glu?Glu?Asn?Phe

200 205 210

cgc?agc?atc?gtt?gaa?cca?ctg?gca?gat?gca?ttg?ggc?ggt?gcc?gtt?ggc 787

Arg?Ser?Ile?Val?Glu?Pro?Leu?Ala?Asp?Ala?Leu?Gly?Gly?Ala?Val?Gly

215 220 225

gca?acc?cgc?gac?gcc?gtt?gat?ctg?ggc?tac?tac?cca?ggc?gag?tac?cag 835

Ala?Thr?Arg?Asp?Ala?Val?Asp?Leu?Gly?Tyr?Tyr?Pro?Gly?Glu?Tyr?Gln

230 235 240 245

gtt?ggt?cag?acc?ggt?gtc?acc?gtg?tcc?cca?gac?ctc?tac?atc?ggc?ctc 883

Val?Gly?Gln?Thr?Gly?Val?Thr?Val?Ser?Pro?Asp?Leu?Tyr?Ile?Gly?Leu

250 255 260

ggc?att?tcc?ggt?gca?att?cag?cac?act?tct?ggt?atg?cag?acc?gca?aag 931

Gly?Ile?Ser?Gly?Ala?Ile?Gln?His?Thr?Ser?Gly?Met?Gln?Thr?Ala?Lys

265 270 275

aag?gtt?att?gtg?atc?aac?aac?gat?gag?gac?gcg?ccg?atc?ttc?cag?att 979

Lys?Val?Ile?Val?Ile?Asn?Asn?Asp?Glu?Asp?Ala?Pro?Ile?Phe?Gln?Ile

280 285 290

gcg?gac?ctc?ggt?gtc?gtt?ggc?gac?ctc?ttt?gac?atc?gcc?cct?gcg?ctc 1027

Ala?Asp?Leu?Gly?Val?Val?Gly?Asp?Leu?Phe?Asp?Ile?Ala?Pro?Ala?Leu

295 300 305

atc?gaa?gag?atc?aac?aag?cgc?aag?taggagtttt?gaacactttt?tat 1074

Ile?Glu?Glu?Ile?Asn?Lys?Arg?Lys

310 315

<210>680

<211>317

<212>PRT

＜213〉Corynebacterium glutamicum

<400>680

Met?Ser?Ile?Ser?Tyr?Val?Leu?Val?Glu?Gln?Leu?Asp?Gly?Arg?Pro?Glu

1 5 10 15

Pro?Val?Thr?Leu?Glu?Leu?Ile?Thr?Ala?Ala?Arg?Ala?Leu?Gly?Asp?Val

20 25 30

Val?Ala?Val?Val?Val?Gly?Glu?Pro?Gly?Ala?Gly?Val?Asn?Leu?Ala?Ala

35 40 45

Glu?Leu?Gly?Asn?Trp?Gly?Ala?Ala?Gln?Val?Val?Ser?Ala?Glu?Ile?Ser

50 55 60

Gly?Ala?Ser?Asn?Arg?Leu?Ile?Leu?Pro?Ala?Val?Asp?Ala?Leu?His?Ile

65 70 75 80

Leu?Ala?Ala?Asn?Asn?Pro?Gly?Pro?Ile?Val?Ile?Ala?Ala?Thr?Ala?Ser

85 90 95

Gly?Asn?Glu?Ile?Ala?Gly?Arg?Leu?Ala?Ala?Arg?Leu?Ala?Ser?Gly?Val

100 105 110

Leu?Thr?Asp?Val?Val?Gly?Ile?Asn?Ala?Asp?Arg?Thr?Ala?Gln?Gln?Ser

115 120 125

Ile?Phe?Gly?Asp?Thr?Ile?Gln?Val?Ser?Ala?Ala?Val?Gly?Gly?Ala?Ser

130 135 140

Pro?Leu?Tyr?Thr?Leu?Arg?Pro?Gly?Ala?Leu?Asp?Gly?Val?Ala?Val?Pro

145 150 155 160

Ala?Thr?Gly?Glu?Leu?Ala?Thr?Ile?Glu?Ile?Pro?Gly?Ala?Thr?Ala?Lys

165 170 175

Asp?Val?Thr?Ile?Thr?Ser?Phe?Thr?Pro?Ser?Thr?Gln?Ser?Asp?Arg?Pro

180 185 190

Glu?Leu?Pro?Gln?Ala?Lys?Val?Val?Ile?Ala?Gly?Gly?Arg?Gly?Val?Gly

195 200 205

Ser?Glu?Glu?Asn?Phe?Arg?Ser?Ile?Val?Glu?Pro?Leu?Ala?Asp?Ala?Leu

210 215 220

Gly?Gly?Ala?Val?Gly?Ala?Thr?Arg?Asp?Ala?Val?Asp?Leu?Gly?Tyr?Tyr

225 230 235 240

Pro?Gly?Glu?Tyr?Gln?Val?Gly?Gln?Thr?Gly?Val?Thr?Val?Ser?Pro?Asp

245 250 255

Leu?Tyr?Ile?Gly?Leu?Gly?Ile?Ser?Gly?Ala?Ile?Gln?His?Thr?Ser?Gly

260 265 270

Met?Gln?Thr?Ala?Lys?Lys?Val?Ile?Val?Ile?Asn?Asn?Asp?Glu?Asp?Ala

275 280 285

Pro?Ile?Phe?Gln?Ile?Ala?Asp?Leu?Gly?Val?Val?Gly?Asp?Leu?Phe?Asp

290 295 300

Ile?Ala?Pro?Ala?Leu?Ile?Glu?Glu?Ile?Asn?Lys?Arg?Lys

305 310 315

<210>681

<211>909

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(886)

<223>RXA00225

<400>681

gtaggcgtcg?aaaagcaatg?ggcgaagccc?gcgtagtatg?ggcgggcaac?gctaaaagcg?60

ccaaaaacgc?caaaaatcgt?gaattgaaag?gtgagtgtgg?atg?tcc?aca?atc?gtg 115

Met?Ser?Thr?Ile?Val

1 5

gtt?ctg?gtt?aaa?aat?gtt?cca?gac?acc?tgg?tct?aag?agg?act?ctg?gaa 163

Val?Leu?Val?Lys?Asn?Val?Pro?Asp?Thr?Trp?Ser?Lys?Arg?Thr?Leu?Glu

10 15 20

gct?gat?ttc?acc?ctt?gac?cgt?gag?ggt?gta?gat?cga?gtc?ttg?gat?gag 211

Ala?Asp?Phe?Thr?Leu?Asp?Arg?Glu?Gly?Val?Asp?Arg?Val?Leu?Asp?Glu

25 30 35

atc?aat?gag?ttt?gct?ctg?gag?cag?gca?ctg?cgc?ttg?cgg?gag?tcc?aac 259

Ile?Asn?Glu?Phe?Ala?Leu?Glu?Gln?Ala?Leu?Arg?Leu?Arg?Glu?Ser?Asn

40 45 50

ccg?gat?gct?ggt?tac?cgc?gtt?gtt?gcg?ctg?agc?gcc?ggc?cct?gcc?ggt 307

Pro?Asp?Ala?Gly?Tyr?Arg?Val?Val?Ala?Leu?Ser?Ala?Gly?Pro?Ala?Gly

55 60 65

ggg?gaa?gag?gcg?ctg?cgt?aag?gcg?ctg?tcc?atg?ggt?gct?gat?gaa?gca 355

Gly?Glu?Glu?Ala?Leu?Arg?Lys?Ala?Leu?Ser?Met?Gly?Ala?Asp?Glu?Ala

70 75 80 85

atc?cag?ctc?agt?gat?gat?gcc?ttg?gct?ggt?tct?gat?ctt?ttg?gga?acc 403

Ile?Gln?Leu?Ser?Asp?Asp?Ala?Leu?Ala?Gly?Ser?Asp?Leu?Leu?Gly?Thr

90 95 100

gct?tgg?gcg?ctg?aac?aac?gct?atc?aac?acc?atc?gcg?ggt?gtt?gct?ctc 451

Ala?Trp?Ala?Leu?Asn?Asn?Ala?Ile?Asn?Thr?Ile?Ala?Gly?Val?Ala?Leu

105 110 115

atc?gtg?acg?ggt?tcg?gct?tct?tcc?gat?ggt?tcc?atg?ggt?gcg?ctt?cct 499

Ile?Val?Thr?Gly?Ser?Ala?Ser?Ser?Asp?Gly?Ser?Met?Gly?Ala?Leu?Pro

120 125 130

ggc?gtg?tta?gct?gag?tac?cgc?cag?gtc?cca?gcg?ttg?act?aac?ttg?tct 547

Gly?Val?Leu?Ala?Glu?Tyr?Arg?Gln?Val?Pro?Ala?Leu?Thr?Asn?Leu?Ser

135 140 145

gcg?ctg?aag?gtc?gag?ggt?gca?tct?att?act?gcc?act?cgc?att?gat?aac 595

Ala?Leu?Lys?Val?Glu?Gly?Ala?Ser?Ile?Thr?Ala?Thr?Arg?Ile?Asp?Asn

150 155 160 165

cac?ggc?acc?tat?gag?ttg?cag?gct?gca?ctt?cct?gcg?gtt?gtg?tcg?att 643

His?Gly?Thr?Tyr?Glu?Leu?Gln?Ala?Ala?Leu?Pro?Ala?Val?Val?Ser?Ile

170 175 180

tcc?gat?aag?gct?gac?aag?cca?cgt?ttc?cct?aac?ttc?aag?ggc?atc?atg 691

Ser?Asp?Lys?Ala?Asp?Lys?Pro?Arg?Phe?Pro?Asn?Phe?Lys?Gly?Ile?Met

185 190 195

gct?gct?aag?aag?gct?gag?atc?aag?aag?ctt?tcc?ttg?gct?gaa?atc?ggc 739

Ala?Ala?Lys?Lys?Ala?Glu?Ile?Lys?Lys?Leu?Ser?Leu?Ala?Glu?Ile?Gly

200 205 210

gtg?gct?cca?gag?cag?gtt?ggt?ctg?tct?cac?gcg?gca?act?gct?gtt?act 787

Val?Ala?Pro?Glu?Gln?Val?Gly?Leu?Ser?His?Ala?Ala?Thr?Ala?Val?Thr

215 220 225

gct?gca?gct?gat?cgt?cct?gag?cgc?tcc?caa?ggt?gat?gtc?att?ggt?gca 835

Ala?Ala?Ala?Asp?Arg?Pro?Glu?Arg?Ser?Gln?Gly?Asp?Val?Ile?Gly?Ala

230 235 240 245

tcg?ggt?gct?gct?gaa?aag?att?gct?gag?tac?ctc?gct?tca?gag?aac?ctc 883

Ser?Gly?Ala?Ala?Glu?Lys?Ile?Ala?Glu?Tyr?Leu?Ala?Ser?Glu?Asn?Leu

250 255 260

atc?tagccactat?cttcacaaag?gag 909

Ile

<210>682

<211>262

<212>PRT

＜213〉Corynebacterium glutamicum

<400>682

Met?Ser?Thr?Ile?Val?Val?Leu?Val?Lys?Asn?Val?Pro?Asp?Thr?Trp?Ser

1 5 10 15

Lys?Arg?Thr?Leu?Glu?Ala?Asp?Phe?Thr?Leu?Asp?Arg?Glu?Gly?Val?Asp

20 25 30

Arg?Val?Leu?Asp?Glu?Ile?Asn?Glu?Phe?Ala?Leu?Glu?Gln?Ala?Leu?Arg

35 40 45

Leu?Arg?Glu?Ser?Asn?Pro?Asp?Ala?Gly?Tyr?Arg?Val?Val?Ala?Leu?Ser

50 55 60

Ala?Gly?Pro?Ala?Gly?Gly?Glu?Glu?Ala?Leu?Arg?Lys?Ala?Leu?Ser?Met

65 70 75 80

Gly?Ala?Asp?Glu?Ala?Ile?Gln?Leu?Ser?Asp?Asp?Ala?Leu?Ala?Gly?Ser

85 90 95

Asp?Leu?Leu?Gly?Thr?Ala?Trp?Ala?Leu?Asn?Asn?Ala?Ile?Asn?Thr?Ile

100 105 110

Ala?Gly?Val?Ala?Leu?Ile?Val?Thr?Gly?Ser?Ala?Ser?Ser?Asp?Gly?Ser

115 120 125

Met?Gly?Ala?Leu?Pro?Gly?Val?Leu?Ala?Glu?Tyr?Arg?Gln?Val?Pro?Ala

130 135 140

Leu?Thr?Asn?Leu?Ser?Ala?Leu?Lys?Val?Glu?Gly?Ala?Ser?Ile?Thr?Ala

145 150 155 160

Thr?Arg?Ile?Asp?Asn?His?Gly?Thr?Tyr?Glu?Leu?Gln?Ala?Ala?Leu?Pro

165 170 175

Ala?Val?Val?Ser?Ile?Ser?Asp?Lys?Ala?Asp?Lys?Pro?Arg?Phe?Pro?Asn

180 185 190

Phe?Lys?Gly?Ile?Met?Ala?Ala?Lys?Lys?Ala?Glu?Ile?Lys?Lys?Leu?Ser

195 200 205

Leu?Ala?Glu?Ile?Gly?Val?Ala?Pro?Glu?Gln?Val?Gly?Leu?Ser?His?Ala

210 215 220

Ala?Thr?Ala?Val?Thr?Ala?Ala?Ala?Asp?Arg?Pro?Glu?Arg?Ser?Gln?Gly

225 230 235 240

Asp?Val?Ile?Gly?Ala?Ser?Gly?Ala?Ala?Glu?Lys?Ile?Ala?Glu?Tyr?Leu

245 250 255

Ala?Ser?Glu?Asn?Leu?Ile

260

<210>683

<211>2378

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(82)..(2355)

<223>RXN00606

<400>683

tgcggtggcg?attgctgcga?cccaagctgg?caccaccagc?ctcgatggta?ttttgcactc?60

tgatttctgg?cggagaagcc?a?gtg?ctc?acg?ggt?gtt?att?gcg?gtg?ctg?att 111

Val?Leu?Thr?Gly?Val?Ile?Ala?Val?Leu?Ile

1 5 10

gca?atg?tcc?gcg?ttc?act?aag?tcc?gca?cag?ttc?ccg?ttc?cac?ttc?tgg 159

Ala?Met?Ser?Ala?Phe?Thr?Lys?Ser?Ala?Gln?Phe?Pro?Phe?His?Phe?Trp

15 20 25

ctg?cct?gag?gcg?atg?gct?gcg?gcc?acc?cca?gtg?tcg?gcg?ttc?ctg?cac 207

Leu?Pro?Glu?Ala?Met?Ala?Ala?Ala?Thr?Pro?Val?Ser?Ala?Phe?Leu?His

30 35 40

gct?gcg?gcc?gtg?gtc?aag?gcg?ggt?att?tac?ctg?ttg?ctg?cgc?ttt?agc 255

Ala?Ala?Ala?Val?Val?Lys?Ala?Gly?Ile?Tyr?Leu?Leu?Leu?Arg?Phe?Ser

45 50 55

att?gtg?ttc?cat?gat?gtt?gcg?gtc?tgg?aat?tgg?ttg?ctg?att?atc?gtc 303

Ile?Val?Phe?His?Asp?Val?Ala?Val?Trp?Asn?Trp?Leu?Leu?Ile?Ile?Val

60 65 70

ggc?atg?ggt?acg?gcc?atc?atg?tcg?gcg?tat?ttc?gcg?gtg?cag?aag?acc 351

Gly?Met?Gly?Thr?Ala?Ile?Met?Ser?Ala?Tyr?Phe?Ala?Val?Gln?Lys?Thr

75 80 85 90

gat?ctg?aag?aag?ctc?acg?gca?tat?tcc?acg?gtg?tcg?cat?ttg?ggt?tgg 399

Asp?Leu?Lys?Lys?Leu?Thr?Ala?Tyr?Ser?Thr?Val?Ser?His?Leu?Gly?Trp

95 100 105

atc?gta?gcg?acc?atc?ggc?gtg?ggc?act?cct?ttc?gcg?ctc?ggc?gct?gcc 447

Ile?Val?Ala?Thr?Ile?Gly?Val?Gly?Thr?Pro?Phe?Ala?Leu?Gly?Ala?Ala

110 115 120

att?gtg?cac?acg?ctc?agc?cac?gcg?ctg?ttt?aag?tcc?tcg?ttg?ttc?atg 495

Ile?Val?His?Thr?Leu?Ser?His?Ala?Leu?Phe?Lys?Ser?Ser?Leu?Phe?Met

125 130 135

ctc?att?ggc?gtg?att?gat?cac?cag?act?ggc?acg?cgc?gat?att?cgt?cgc 543

Leu?Ile?Gly?Val?Ile?Asp?His?Gln?Thr?Gly?Thr?Arg?Asp?Ile?Arg?Arg

140 145 150

ctc?ggt?ttc?ctg?gtc?aag?aag?atg?ccg?ttc?acg?ttt?gtg?tct?gta?tta 591

Leu?Gly?Phe?Leu?Val?Lys?Lys?Met?Pro?Phe?Thr?Phe?Val?Ser?Val?Leu

155 160 165 170

ata?ggt?gcg?ttg?tcg?atg?gca?tcg?gtt?ccg?ccg?ttg?ctc?ggc?ttc?gtg 639

Ile?Gly?Ala?Leu?Ser?Met?Ala?Ser?Val?Pro?Pro?Leu?Leu?Gly?Phe?Val

175 180 185

tcc?aaa?gaa?ggc?atg?atc?aca?gcg?ttc?atg?gac?gcc?ccc?atc?ggc?aac 687

Ser?Lys?Glu?Gly?Met?Ile?Thr?Ala?Phe?Met?Asp?Ala?Pro?Ile?Gly?Asn

190 195 200

tcc?tat?gtt?gta?tta?ctg?ctg?gtc?ggc?gca?gca?atc?ggc?gcg?gtc?cta 735

Ser?Tyr?Val?Val?Leu?Leu?Leu?Val?Gly?Ala?Ala?Ile?Gly?Ala?Val?Leu

205 210 215

acc?ttc?aca?tac?tcc?gcg?aaa?ctc?gtg?ctc?ggc?gca?ttc?gtc?gac?ggc 783

Thr?Phe?Thr?Tyr?Ser?Ala?Lys?Leu?Val?Leu?Gly?Ala?Phe?Val?Asp?Gly

220 225 230

cca?cgc?gac?atg?tca?cac?gtc?aag?gaa?gcc?ccc?gtc?tcc?ctc?tgg?ctt 831

Pro?Arg?Asp?Met?Ser?His?Val?Lys?Glu?Ala?Pro?Val?Ser?Leu?Trp?Leu

235 240 245 250

ccg?gcc?gcc?ctg?cct?gga?ctt?atg?tct?ctg?cca?cta?gtc?cta?gta?ctt 879

Pro?Ala?Ala?Leu?Pro?Gly?Leu?Met?Ser?Leu?Pro?Leu?Val?Leu?Val?Leu

255 260 265

tcg?ctt?ttc?gac?gcc?ccc?gtc?tcc?gcc?gca?gcc?acc?tcc?gcc?gcg?ggg 927

Ser?Leu?Phe?Asp?Ala?Pro?Val?Ser?Ala?Ala?Ala?Thr?Ser?Ala?Ala?Gly

270 275 280

gaa?gcg?gcg?cac?atg?cac?ctg?gca?ttg?tgg?cac?ggc?atc?aac?acc?cca 975

Glu?Ala?Ala?His?Met?His?Leu?Ala?Leu?Trp?His?Gly?Ile?Asn?Thr?Pro

285 290 295

ctg?ttg?att?tcc?ttg?ggt?gtg?ctg?gtg?gcc?gga?atc?ctt?ggt?gtg?ctg 1023

Leu?Leu?Ile?Ser?Leu?Gly?Val?Leu?Val?Ala?Gly?Ile?Leu?Gly?Val?Leu

300 305 310

ttc?cgc?aaa?gag?ctg?tgg?aaa?atc?gcc?gag?acc?agc?cct?ttc?ccc?atc 1071

Phe?Arg?Lys?Glu?Leu?Trp?Lys?Ile?Ala?Glu?Thr?Ser?Pro?Phe?Pro?Ile

315 320 325 330

gcc?aca?ggc?aac?gac?atc?cta?tcg?atg?ctg?gtt?tac?cga?gcc?aac?ttg 1119

Ala?Thr?Gly?Asn?Asp?Ile?Leu?Ser?Met?Leu?Val?Tyr?Arg?Ala?Asn?Leu

335 340 345

ctg?ggt?aaa?ttc?ttc?ggt?cgc?atg?gct?gat?tcg?atg?agc?cca?cgc?agg 1167

Leu?Gly?Lys?Phe?Phe?Gly?Arg?Met?Ala?Asp?Ser?Met?Ser?Pro?Arg?Arg

350 355 360

cac?ttg?gtc?agc?ctc?atc?gtg?ctg?ctc?tgg?gcg?ctg?gct?gct?ttt?gcc 1215

His?Leu?Val?Ser?Leu?Ile?Val?Leu?Leu?Trp?Ala?Leu?Ala?Ala?Phe?Ala

365 370 375

acc?att?cac?ccc?tcg?gtt?cag?ctt?gca?cca?aag?caa?ccg?gga?att?gat 1263

Thr?Ile?His?Pro?Ser?Val?Gln?Leu?Ala?Pro?Lys?Gln?Pro?Gly?Ile?Asp

380 385 390

cgt?tgg?atc?gac?ctc?att?ccg?ctt?gcc?atc?atc?gcg?cta?tct?gtc?ttc 1311

Arg?Trp?Ile?Asp?Leu?Ile?Pro?Leu?Ala?Ile?Ile?Ala?Leu?Ser?Val?Phe

395 400 405 410

ggc?ctg?ctc?acc?acc?cga?aac?cgc?ctc?agc?gca?gcc?gtg?ctt?gtg?ggt 1359

Gly?Leu?Leu?Thr?Thr?Arg?Asn?Arg?Leu?Ser?Ala?Ala?Val?Leu?Val?Gly

415 420 425

acc?gtt?ggt?gtg?ggt?gtt?tcc?ttc?cag?atg?cta?ctt?ctg?ggc?gct?ccc 1407

Thr?Val?Gly?Val?Gly?Val?Ser?Phe?Gln?Met?Leu?Leu?Leu?Gly?Ala?Pro

430 435 440

gat?gtt?gca?ctt?acc?cag?ttc?ctg?gta?gaa?ggc?ctc?gtc?gtg?gta?atc 1455

Asp?Val?Ala?Leu?Thr?Gln?Phe?Leu?Val?Glu?Gly?Leu?Val?Val?Val?Ile

445 450 455

atc?atg?atg?gtt?gtc?cgg?cac?cag?cct?gcc?aac?ttc?aag?cgc?atc?aag 1503

Ile?Met?Met?Val?Val?Arg?His?Gln?Pro?Ala?Asn?Phe?Lys?Arg?Ile?Lys

460 465 470

ccc?agc?aga?agg?cgc?agc?acc?gtt?ctt?gtc?gcc?gtc?ctt?gct?gcc?ttc 1551

Pro?Ser?Arg?Arg?Arg?Ser?Thr?Val?Leu?Val?Ala?Val?Leu?Ala?Ala?Phe

475 480 485 490

gcc?gca?ttc?atg?gcg?gtg?tgg?gga?ttg?ctt?ggc?cgt?cac?gaa?cgt?tct 1599

Ala?Ala?Phe?Met?Ala?Val?Trp?Gly?Leu?Leu?Gly?Arg?His?Glu?Arg?Ser

495 500 505

gag?ctg?gcc?atg?tgg?tac?ctc?aac?caa?ggt?cca?gag?atc?acc?tct?ggc 1647

Glu?Leu?Ala?Met?Trp?Tyr?Leu?Asn?Gln?Gly?Pro?Glu?Ile?Thr?Ser?Gly

510 515 520

gcc?aac?gtg?gtg?aac?acc?atc?ctc?gtg?gaa?ttc?cgt?gca?ctg?gat?acg 1695

Ala?Asn?Val?Val?Asn?Thr?Ile?Leu?Val?Glu?Phe?Arg?Ala?Leu?Asp?Thr

525 530 535

ttg?ggc?gag?ctc?tcc?gtg?ctt?ggc?atg?gca?gct?gtc?gtc?atc?ggt?gcg 1743

Leu?Gly?Glu?Leu?Ser?Val?Leu?Gly?Met?Ala?Ala?Val?Val?Ile?Gly?Ala

540 545 550

atg?gtg?gct?tcc?atg?cct?cgt?cat?ccg?ttt?gcc?aag?ggc?acc?cac?cct 1791

Met?Val?Ala?Ser?Met?Pro?Arg?His?Pro?Phe?Ala?Lys?Gly?Thr?His?Pro

555 560 565 570

cgc?ccc?ttt?ggc?caa?tca?cag?ttg?aac?tcc?att?ccg?ctg?cgc?atg?ctg 1839

Arg?Pro?Phe?Gly?Gln?Ser?Gln?Leu?Asn?Ser?Ile?Pro?Leu?Arg?Met?Leu

575 580 585

ctt?aag?gtg?ctg?gtt?cca?gcg?cta?tgc?ttc?ttg?agc?ttc?atg?gtg?ttc 1887

Leu?Lys?Val?Leu?Val?Pro?Ala?Leu?Cys?Phe?Leu?Ser?Phe?Met?Val?Phe

590 595 600

atg?cgt?gga?cac?aat?gat?ccg?gga?ggc?ggt?ttc?atc?gca?gcc?cta?att 1935

Met?Arg?Gly?His?Asn?Asp?Pro?Gly?Gly?Gly?Phe?Ile?Ala?Ala?Leu?Ile

605 610 615

gcc?ggt?ggc?gcg?ctg?atg?ctc?ctg?tac?ctg?tcc?aag?gcc?aaa?gat?ggc 1983

Ala?Gly?Gly?Ala?Leu?Met?Leu?Leu?Tyr?Leu?Ser?Lys?Ala?Lys?Asp?Gly

620 625 630

cgc?att?ttc?cgc?ccg?aat?gtt?cct?ttc?att?ctc?act?ggt?gcg?ggc?atc 2031

Arg?Ile?Phe?Arg?Pro?Asn?Val?Pro?Phe?Ile?Leu?Thr?Gly?Ala?Gly?Ile

635 640 645 650

ttg?atg?gca?gtg?ttc?tcg?ggc?gta?ctg?gga?ctc?acc?cac?ggt?tct?ttc 2079

Leu?Met?Ala?Val?Phe?Ser?Gly?Val?Leu?Gly?Leu?Thr?His?Gly?Ser?Phe

655 660 665

ctg?tac?gcc?atc?cac?ttc?aac?ttc?gta?ggc?cag?cac?tgg?acc?acc?tcg 2127

Leu?Tyr?Ala?Ile?His?Phe?Asn?Phe?Val?Gly?Gln?His?Trp?Thr?Thr?Ser

670 675 680

atg?atc?ttc?gac?ctc?ggc?gtg?tac?ctg?gcc?gtg?ttg?ggc?atg?gtg?tcc 2175

Met?Ile?Phe?Asp?Leu?Gly?Val?Tyr?Leu?Ala?Val?Leu?Gly?Met?Val?Ser

685 690 695

atg?gca?atc?aac?ggc?ctg?ggc?gga?tac?ctg?cgc?cca?ggt?acc?gac?aat 2223

Met?Ala?Ile?Asn?Gly?Leu?Gly?Gly?Tyr?Leu?Arg?Pro?Gly?Thr?Asp?Asn

700 705 710

gca?gat?ctg?gac?tac?gcc?cgc?cga?agt?ggc?cca?ctg?cca?gca?acg?cca 2271

Ala?Asp?Leu?Asp?Tyr?Ala?Arg?Arg?Ser?Gly?Pro?Leu?Pro?Ala?Thr?Pro

715 720 725 730

acg?gtt?gaa?ccc?gaa?cca?gaa?ggc?gat?gaa?gac?tgg?ccc?gaa?ccc?atc 2319

Thr?Val?Glu?Pro?Glu?Pro?Glu?Gly?Asp?Glu?Asp?Trp?Pro?Glu?Pro?Ile

735 740 745

aac?ccc?gca?ggc?gat?aac?aaa?gag?gag?gca?aac?cga?tgattctcgc 2365

Asn?Pro?Ala?Gly?Asp?Asn?Lys?Glu?Glu?Ala?Asn?Arg

750 755

actgacagtc?gcg 2378

<210>684

<211>758

<212>PRT

＜213〉Corynebacterium glutamicum

<400>684

Val?Leu?Thr?Gly?Val?Ile?Ala?Val?Leu?Ile?Ala?Met?Ser?Ala?Phe?Thr

1 5 10 15

Lys?Ser?Ala?Gln?Phe?Pro?Phe?His?Phe?Trp?Leu?Pro?Glu?Ala?Met?Ala

20 25 30

Ala?Ala?Thr?Pro?Val?Ser?Ala?Phe?Leu?His?Ala?Ala?Ala?Val?Val?Lys

35 40 45

Ala?Gly?Ile?Tyr?Leu?Leu?Leu?Arg?Phe?Ser?Ile?Val?Phe?His?Asp?Val

50 55 60

Ala?Val?Trp?Asn?Trp?Leu?Leu?Ile?Ile?Val?Gly?Met?Gly?Thr?Ala?Ile

65 70 75 80

Met?Ser?Ala?Tyr?Phe?Ala?Val?Gln?Lys?Thr?Asp?Leu?Lys?Lys?Leu?Thr

85 90 95

Ala?Tyr?Ser?Thr?Val?Ser?His?Leu?Gly?Trp?Ile?Val?Ala?Thr?Ile?Gly

100 105 110

Val?Gly?Thr?Pro?Phe?Ala?Leu?Gly?Ala?Ala?Ile?Val?His?Thr?Leu?Ser

115 120 125

His?Ala?Leu?Phe?Lys?Ser?Ser?Leu?Phe?Met?Leu?Ile?Gly?Val?Ile?Asp

130 135 140

His?Gln?Thr?Gly?Thr?Arg?Asp?Ile?Arg?Arg?Leu?Gly?Phe?Leu?Val?Lys

145 150 155 160

Lys?Met?Pro?Phe?Thr?Phe?Val?Ser?Val?Leu?Ile?Gly?Ala?Leu?Ser?Met

165 170 175

Ala?Ser?Val?Pro?Pro?Leu?Leu?Gly?Phe?Val?Ser?Lys?Glu?Gly?Met?Ile

180 185 190

Thr?Ala?Phe?Met?Asp?Ala?Pro?Ile?Gly?Asn?Ser?Tyr?Val?Val?Leu?Leu

195 200 205

Leu?Val?Gly?Ala?Ala?Ile?Gly?Ala?Val?Leu?Thr?Phe?Thr?Tyr?Ser?Ala

210 215 220

Lys?Leu?Val?Leu?Gly?Ala?Phe?Val?Asp?Gly?Pro?Arg?Asp?Met?Ser?His

225 230 235 240

Val?Lys?Glu?Ala?Pro?Val?Ser?Leu?Trp?Leu?Pro?Ala?Ala?Leu?Pro?Gly

245 250 255

Leu?Met?Ser?Leu?Pro?Leu?Val?Leu?Val?Leu?Ser?Leu?Phe?Asp?Ala?Pro

260 265 270

Val?Ser?Ala?Ala?Ala?Thr?Ser?Ala?Ala?Gly?Glu?Ala?Ala?His?Met?His

275 280 285

Leu?Ala?Leu?Trp?His?Gly?Ile?Asn?Thr?Pro?Leu?Leu?Ile?Ser?Leu?Gly

290 295 300

Val?Leu?Val?Ala?Gly?Ile?Leu?Gly?Val?Leu?Phe?Arg?Lys?Glu?Leu?Trp

305 310 315 320

Lys?Ile?Ala?Glu?Thr?Ser?Pro?Phe?Pro?Ile?Ala?Thr?Gly?Asn?Asp?Ile

325 330 335

Leu?Ser?Met?Leu?Val?Tyr?Arg?Ala?Asn?Leu?Leu?Gly?Lys?Phe?Phe?Gly

340 345 350

Arg?Met?Ala?Asp?Ser?Met?Ser?Pro?Arg?Arg?His?Leu?Val?Ser?Leu?Ile

355 360 365

Val?Leu?Leu?Trp?Ala?Leu?Ala?Ala?Phe?Ala?Thr?Ile?His?Pro?Ser?Val

370 375 380

Gln?Leu?Ala?Pro?Lys?Gln?Pro?Gly?Ile?Asp?Arg?Trp?Ile?Asp?Leu?Ile

385 390 395 400

Pro?Leu?Ala?Ile?Ile?Ala?Leu?Ser?Val?Phe?Gly?Leu?Leu?Thr?Thr?Arg

405 410 415

Asn?Arg?Leu?Ser?Ala?Ala?Val?Leu?Val?Gly?Thr?Val?Gly?Val?Gly?Val

420 425 430

Ser?Phe?Gln?Met?Leu?Leu?Leu?Gly?Ala?Pro?Asp?Val?Ala?Leu?Thr?Gln

435 440 445

Phe?Leu?Val?Glu?Gly?Leu?Val?Val?Val?Ile?Ile?Met?Met?Val?Val?Arg

450 455 460

His?Gln?Pro?Ala?Asn?Phe?Lys?Arg?Ile?Lys?Pro?Ser?Arg?Arg?Arg?Ser

465 470 475 480

Thr?Val?Leu?Val?Ala?Val?Leu?Ala?Ala?Phe?Ala?Ala?Phe?Met?Ala?Val

485 490 495

Trp?Gly?Leu?Leu?Gly?Arg?His?Glu?Arg?Ser?Glu?Leu?Ala?Met?Trp?Tyr

500 505 510

Leu?Asn?Gln?Gly?Pro?Glu?Ile?Thr?Ser?Gly?Ala?Asn?Val?Val?Asn?Thr

515 520 525

Ile?Leu?Val?Glu?Phe?Arg?Ala?Leu?Asp?Thr?Leu?Gly?Glu?Leu?Ser?Val

530 535 540

Leu?Gly?Met?Ala?Ala?Val?Val?Ile?Gly?Ala?Met?Val?Ala?Ser?Met?Pro

545 550 555 560

Arg?His?Pro?Phe?Ala?Lys?Gly?Thr?His?Pro?Arg?Pro?Phe?Gly?Gln?Ser

565 570 575

Gln?Leu?Asn?Ser?Ile?Pro?Leu?Arg?Met?Leu?Leu?Lys?Val?Leu?Val?Pro

580 585 590

Ala?Leu?Cys?Phe?Leu?Ser?Phe?Met?Val?Phe?Met?Arg?Gly?His?Asn?Asp

595 600 605

Pro?Gly?Gly?Gly?Phe?Ile?Ala?Ala?Leu?Ile?Ala?Gly?Gly?Ala?Leu?Met

610 615 620

Leu?Leu?Tyr?Leu?Ser?Lys?Ala?Lys?Asp?Gly?Arg?Ile?Phe?Arg?Pro?Asn

625 630 635 640

Val?Pro?Phe?Ile?Leu?Thr?Gly?Ala?Gly?Ile?Leu?Met?Ala?Val?Phe?Ser

645 650 655

Gly?Val?Leu?Gly?Leu?Thr?His?Gly?Ser?Phe?Leu?Tyr?Ala?Ile?His?Phe

660 665 670

Asn?Phe?Val?Gly?Gln?His?Trp?Thr?Thr?Ser?Met?Ile?Phe?Asp?Leu?Gly

675 680 685

Val?Tyr?Leu?Ala?Val?Leu?Gly?Met?Val?Ser?Met?Ala?Ile?Asn?Gly?Leu

690 695 700

Gly?Gly?Tyr?Leu?Arg?Pro?Gly?Thr?Asp?Asn?Ala?Asp?Leu?Asp?Tyr?Ala

705 710 715 720

Arg?Arg?Ser?Gly?Pro?Leu?Pro?Ala?Thr?Pro?Thr?Val?Glu?Pro?Glu?Pro

725 730 735

Glu?Gly?Asp?Glu?Asp?Trp?Pro?Glu?Pro?Ile?Asn?Pro?Ala?Gly?Asp?Asn

740 745 750

Lys?Glu?Glu?Ala?Asn?Arg

755

<210>685

<211>1872

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1849)

<223>FRXA00606

<400>685

atggataacc?agactggcac?gcgcgatatt?cgtcgcctcg?gtttcctggt?caagaaaaat?60

gccgttcacg?tttgtgtctg?tattaatagg?tgcgttgtcg?atg?gca?tcg?gtt?ccg 115

Met?Ala?Ser?Val?Pro

1 5

ccg?ttg?ctc?ggc?ttc?gtg?tcc?aaa?gaa?ggc?atg?atc?aca?gcg?ttc?atg 163

Pro?Leu?Leu?Gly?Phe?Val?Ser?Lys?Glu?Gly?Met?Ile?Thr?Ala?Phe?Met

10 15 20

gac?gcc?ccc?atc?ggc?aac?tcc?tat?gtt?gta?tta?ctg?ctg?gtc?ggc?gca 211

Asp?Ala?Pro?Ile?Gly?Asn?Ser?Tyr?Val?Val?Leu?Leu?Leu?Val?Gly?Ala

25 30 35

gca?atc?ggc?gcg?gtc?cta?acc?ttc?aca?tac?tcc?gcg?aaa?ctc?gtg?ctc 259

Ala?Ile?Gly?Ala?Val?Leu?Thr?Phe?Thr?Tyr?Ser?Ala?Lys?Leu?Val?Leu

40 45 50

ggc?gca?ttc?gtc?gac?ggc?cca?cgc?gac?atg?tca?cac?gtc?aag?gaa?gcc 307

Gly?Ala?Phe?Val?Asp?Gly?Pro?Arg?Asp?Met?Ser?His?Val?Lys?Glu?Ala

55 60 65

ccc?gtc?tcc?ctc?tgg?ctt?ccg?gcc?gcc?ctg?cct?gga?ctt?atg?tct?ctg 355

Pro?Val?Ser?Leu?Trp?Leu?Pro?Ala?Ala?Leu?Pro?Gly?Leu?Met?Ser?Leu

70 75 80 85

cca?cta?gtc?cta?gta?ctt?tcg?ctt?ttc?gac?gcc?ccc?gtc?tcc?gcc?gca 403

Pro?Leu?Val?Leu?Val?Leu?Ser?Leu?Phe?Asp?Ala?Pro?Val?Ser?Ala?Ala

90 95 100

gcc?acc?tcc?gcc?gcg?ggg?gaa?gcg?gcg?cac?atg?cac?ctg?gca?ttg?tgg 451

Ala?Thr?Ser?Ala?Ala?Gly?Glu?Ala?Ala?His?Met?His?Leu?Ala?Leu?Trp

105 110 115

cac?ggc?atc?aac?acc?cca?ctg?ttg?att?tcc?ttg?ggt?gtg?ctg?gtg?gcc 499

His?Gly?Ile?Asn?Thr?Pro?Leu?Leu?Ile?Ser?Leu?Gly?Val?Leu?Val?Ala

120 125 130

gga?atc?ctt?ggt?gtg?ctg?ttc?cgc?aaa?gag?ctg?tgg?aaa?atc?gcc?gag 547

Gly?Ile?Leu?Gly?Val?Leu?Phe?Arg?Lys?Glu?Leu?Trp?Lys?Ile?Ala?Glu

135 140 145

acc?agc?cct?ttc?ccc?atc?gcc?aca?ggc?aac?gac?atc?cta?tcg?atg?ctg 595

Thr?Ser?Pro?Phe?Pro?Ile?Ala?Thr?Gly?Asn?Asp?Ile?Leu?Ser?Met?Leu

150 155 160 165

gtt?tac?cga?gcc?aac?ttg?ctg?ggt?aaa?ttc?ttc?ggt?cgc?atg?gct?gat 643

Val?Tyr?Arg?Ala?Asn?Leu?Leu?Gly?Lys?Phe?Phe?Gly?Arg?Met?Ala?Asp

170 175 180

tcg?atg?agc?cca?cgc?agg?cac?ttg?gtc?agc?ctc?atc?gtg?ctg?ctc?tgg 691

Ser?Met?Ser?Pro?Arg?Arg?His?Leu?Val?Ser?Leu?Ile?Val?Leu?Leu?Trp

185 190 195

gcg?ctg?gct?gct?ttt?gcc?acc?att?cac?ccc?tcg?gtt?cag?ctt?gca?cca 739

Ala?Leu?Ala?Ala?Phe?Ala?Thr?Ile?His?Pro?Ser?Val?Gln?Leu?Ala?Pro

200 205 210

aag?caa?ccg?gga?att?gat?cgt?tgg?atc?gac?ctc?att?ccg?ctt?gcc?atc 787

Lys?Gln?Pro?Gly?Ile?Asp?Arg?Trp?Ile?Asp?Leu?Ile?Pro?Leu?Ala?Ile

215 220 225

atc?gcg?cta?tct?gtc?ttc?ggc?ctg?ctc?acc?acc?cga?aac?cgc?ctc?agc 835

Ile?Ala?Leu?Ser?Val?Phe?Gly?Leu?Leu?Thr?Thr?Arg?Asn?Arg?Leu?Ser

230 235 240 245

gca?gcc?gtg?ctt?gtg?ggt?acc?gtt?ggt?gtg?ggt?gtt?tcc?ttc?cag?atg 883

Ala?Ala?Val?Leu?Val?Gly?Thr?Val?Gly?Val?Gly?Val?Ser?Phe?Gln?Met

250 255 260

cta?ctt?ctg?ggc?gct?ccc?gat?gtt?gca?ctt?acc?cag?ttc?ctg?gta?gaa 931

Leu?Leu?Leu?Gly?Ala?Pro?Asp?Val?Ala?Leu?Thr?Gln?Phe?Leu?Val?Glu

265 270 275

ggc?ctc?gtc?gtg?gta?atc?atc?atg?atg?gtt?gtc?cgg?cac?cag?cct?gcc 979

Gly?Leu?Val?Val?Val?Ile?Ile?Met?Met?Val?Val?Arg?His?Gln?Pro?Ala

280 285 290

aac?ttc?aag?cgc?atc?aag?ccc?agc?aga?agg?cgc?agc?acc?gtt?ctt?gtc 1027

Asn?Phe?Lys?Arg?Ile?Lys?Pro?Ser?Arg?Arg?Arg?Ser?Thr?Val?Leu?Val

295 300 305

gcc?gtc?ctt?gct?gcc?ttc?gcc?gca?ttc?atg?gcg?gtg?tgg?gga?ttg?ctt 1075

Ala?Val?Leu?Ala?Ala?Phe?Ala?Ala?Phe?Met?Ala?Val?Trp?Gly?Leu?Leu

310 315 320 325

ggc?cgt?cac?gaa?cgt?tct?gag?ctg?gcc?atg?tgg?tac?ctc?aac?caa?ggt 1123

Gly?Arg?His?Glu?Arg?Ser?Glu?Leu?Ala?Met?Trp?Tyr?Leu?Asn?Gln?Gly

330 335 340

cca?gag?atc?acc?tct?ggc?gcc?aac?gtg?gtg?aac?acc?atc?ctc?gtg?gaa 1171

Pro?Glu?Ile?Thr?Ser?Gly?Ala?Asn?Val?Val?Asn?Thr?Ile?Leu?Val?Glu

345 350 355

ttc?cgt?gca?ctg?gat?acg?ttg?ggc?gag?ctc?tcc?gtg?ctt?ggc?atg?gca 1219

Phe?Arg?Ala?Leu?Asp?Thr?Leu?Gly?Glu?Leu?Ser?Val?Leu?Gly?Met?Ala

360 365 370

gct?gtc?gtc?atc?ggt?gcg?atg?gtg?gct?tcc?atg?cct?cgt?cat?ccg?ttt 1267

Ala?Val?Val?Ile?Gly?Ala?Met?Val?Ala?Ser?Met?Pro?Arg?His?Pro?Phe

375 380 385

gcc?aag?ggc?acc?cac?cct?cgc?ccc?ttt?ggc?caa?tca?cag?ttg?aac?tcc 1315

Ala?Lys?Gly?Thr?His?Pro?Arg?Pro?Phe?Gly?Gln?Ser?Gln?Leu?Asn?Ser

390 395 400 405

att?ccg?ctg?cgc?atg?ctg?ctt?aag?gtg?ctg?gtt?cca?gcg?cta?tgc?ttc 1363

Ile?Pro?Leu?Arg?Met?Leu?Leu?Lys?Val?Leu?Val?Pro?Ala?Leu?Cys?Phe

410 415 420

ttg?agc?ttc?atg?gtg?ttc?atg?cgt?gga?cac?aat?gat?ccg?gga?ggc?ggt 1411

Leu?Ser?Phe?Met?Val?Phe?Met?Arg?Gly?His?Asn?Asp?Pro?Gly?Gly?Gly

425 430 435

ttc?atc?gca?gcc?cta?att?gcc?ggt?ggc?gcg?ctg?atg?ctc?ctg?tac?ctg 1459

Phe?Ile?Ala?Ala?Leu?Ile?Ala?Gly?Gly?Ala?Leu?Met?Leu?Leu?Tyr?Leu

440 445 450

tcc?aag?gcc?aaa?gat?ggc?cgc?att?ttc?cgc?ccg?aat?gtt?cct?ttc?att 1507

Ser?Lys?Ala?Lys?Asp?Gly?Arg?Ile?Phe?Arg?Pro?Asn?Val?Pro?Phe?Ile

455 460 465

ctc?act?ggt?gcg?ggc?atc?ttg?atg?gca?gtg?ttc?tcg?ggc?gta?ctg?gga 1555

Leu?Thr?Gly?Ala?Gly?Ile?Leu?Met?Ala?Val?Phe?Ser?Gly?Val?Leu?Gly

470 475 480 485

ctc?acc?cac?ggt?tct?ttc?ctg?tac?gcc?atc?cac?ttc?aac?ttc?gta?ggc 1603

Leu?Thr?His?Gly?Ser?Phe?Leu?Tyr?Ala?Ile?His?Phe?Asn?Phe?Val?Gly

490 495 500

cag?cac?tgg?acc?acc?tcg?atg?atc?ttc?gac?ctc?ggc?gtg?tac?ctg?gcc 1651

Gln?His?Trp?Thr?Thr?Ser?Met?Ile?Phe?Asp?Leu?Gly?Val?Tyr?Leu?Ala

505 510 515

gtg?ttg?ggc?atg?gtg?tcc?atg?gca?atc?aac?ggc?ctg?ggc?gga?tac?ctg 1699

Val?Leu?Gly?Met?Val?Ser?Met?Ala?Ile?Asn?Gly?Leu?Gly?Gly?Tyr?Leu

520 525 530

cgc?cca?ggt?acc?gac?aat?gca?gat?ctg?gac?tac?gcc?cgc?cga?agt?ggc 1747

Arg?Pro?Gly?Thr?Asp?Asn?Ala?Asp?Leu?Asp?Tyr?Ala?Arg?Arg?Ser?Gly

535 540 545

cca?ctg?cca?gca?acg?cca?acg?gtt?gaa?ccc?gaa?cca?gaa?ggc?gat?gaa 1795

Pro?Leu?Pro?Ala?Thr?Pro?Thr?Val?Glu?Pro?Glu?Pro?Glu?Gly?Asp?Glu

550 555 560 565

gac?tgg?ccc?gaa?ccc?atc?aac?ccc?gca?ggc?gat?aac?aaa?gag?gag?gca 1843

Asp?Trp?Pro?Glu?Pro?Ile?Asn?Pro?Ala?Gly?Asp?Asn?Lys?Glu?Glu?Ala

570 575 580

aac?cga?tgattctcgc?actgacagtc?gcg 1872

Asn?Arg

<210>686

<211>583

<212>PRT

＜213〉Corynebacterium glutamicum

<400>686

Met?Ala?Ser?Val?Pro?Pro?Leu?Leu?Gly?Phe?Val?Ser?Lys?Glu?Gly?Met

1 5 10 15

Ile?Thr?Ala?Phe?Met?Asp?Ala?Pro?Ile?Gly?Asn?Ser?Tyr?Val?Val?Leu

20 25 30

Leu?Leu?Val?Gly?Ala?Ala?Ile?Gly?Ala?Val?Leu?Thr?Phe?Thr?Tyr?Ser

35 40 45

Ala?Lys?Leu?Val?Leu?Gly?Ala?Phe?Val?Asp?Gly?Pro?Arg?Asp?Met?Ser

50 55 60

His?Val?Lys?Glu?Ala?Pro?Val?Ser?Leu?Trp?Leu?Pro?Ala?Ala?Leu?Pro

65 70 75 80

Gly?Leu?Met?Ser?Leu?Pro?Leu?Val?Leu?Val?Leu?Ser?Leu?Phe?Asp?Ala

85 90 95

Pro?Val?Ser?Ala?Ala?Ala?Thr?Ser?Ala?Ala?Gly?Glu?Ala?Ala?His?Met

100 105 110

His?Leu?Ala?Leu?Trp?His?Gly?Ile?Asn?Thr?Pro?Leu?Leu?Ile?Ser?Leu

115 120 125

Gly?Val?Leu?Val?Ala?Gly?Ile?Leu?Gly?Val?Leu?Phe?Arg?Lys?Glu?Leu

130 135 140

Trp?Lys?Ile?Ala?Glu?Thr?Ser?Pro?Phe?Pro?Ile?Ala?Thr?Gly?Asn?Asp

145 150 155 160

Ile?Leu?Ser?Met?Leu?Val?Tyr?Arg?Ala?Asn?Leu?Leu?Gly?Lys?Phe?Phe

165 170 175

Gly?Arg?Met?Ala?Asp?Ser?Met?Ser?Pro?Arg?Arg?His?Leu?Val?Ser?Leu

180 185 190

Ile?Val?Leu?Leu?Trp?Ala?Leu?Ala?Ala?Phe?Ala?Thr?Ile?His?Pro?Ser

195 200 205

Val?Gln?Leu?Ala?Pro?Lys?Gln?Pro?Gly?Ile?Asp?Arg?Trp?Ile?Asp?Leu

210 215 220

Ile?Pro?Leu?Ala?Ile?Ile?Ala?Leu?Ser?Val?Phe?Gly?Leu?Leu?Thr?Thr

225 230 235 240

Arg?Asn?Arg?Leu?Ser?Ala?Ala?Val?Leu?Val?Gly?Thr?Val?Gly?Val?Gly

245 250 255

Val?Ser?Phe?Gln?Met?Leu?Leu?Leu?Gly?Ala?Pro?Asp?Val?Ala?Leu?Thr

260 265 270

Gln?Phe?Leu?Val?Glu?Gly?Leu?Val?Val?Val?Ile?Ile?Met?Met?Val?Val

275 280 285

Arg?His?Gln?Pro?Ala?Asn?Phe?Lys?Arg?Ile?Lys?Pro?Ser?Arg?Arg?Arg

290 295 300

Ser?Thr?Val?Leu?Val?Ala?Val?Leu?Ala?Ala?Phe?Ala?Ala?Phe?Met?Ala

305 310 315 320

Val?Trp?Gly?Leu?Leu?Gly?Arg?His?Glu?Arg?Ser?Glu?Leu?Ala?Met?Trp

325 330 335

Tyr?Leu?Asn?Gln?Gly?Pro?Glu?Ile?Thr?Ser?Gly?Ala?Asn?Val?Val?Asn

340 345 350

Thr?Ile?Leu?Val?Glu?Phe?Arg?Ala?Leu?Asp?Thr?Leu?Gly?Glu?Leu?Ser

355 360 365

Val?Leu?Gly?Met?Ala?Ala?Val?Val?Ile?Gly?Ala?Met?Val?Ala?Ser?Met

370 375 380

Pro?Arg?His?Pro?Phe?Ala?Lys?Gly?Thr?His?Pro?Arg?Pro?Phe?Gly?Gln

385 390 395 400

Ser?Gln?Leu?Asn?Ser?Ile?Pro?Leu?Arg?Met?Leu?Leu?Lys?Val?Leu?Val

405 410 415

Pro?Ala?Leu?Cys?Phe?Leu?Ser?Phe?Met?Val?Phe?Met?Arg?Gly?His?Asn

420 425 430

Asp?Pro?Gly?Gly?Gly?Phe?Ile?Ala?Ala?Leu?Ile?Ala?Gly?Gly?Ala?Leu

435 440 445

Met?Leu?Leu?Tyr?Leu?Ser?Lys?Ala?Lys?Asp?Gly?Arg?Ile?Phe?Arg?Pro

450 455 460

Asn?Val?Pro?Phe?Ile?Leu?Thr?Gly?Ala?Gly?Ile?Leu?Met?Ala?Val?Phe

465 470 475 480

Ser?Gly?Val?Leu?Gly?Leu?Thr?His?Gly?Ser?Phe?Leu?Tyr?Ala?Ile?His

485 490 495

Phe?Asn?Phe?Val?Gly?Gln?His?Trp?Thr?Thr?Ser?Met?Ile?Phe?Asp?Leu

500 505 510

Gly?Val?Tyr?Leu?Ala?Val?Leu?Gly?Met?Val?Ser?Met?Ala?Ile?Asn?Gly

515 520 525

Leu?Gly?Gly?Tyr?Leu?Arg?Pro?Gly?Thr?Asp?Asn?Ala?Asp?Leu?Asp?Tyr

530 535 540

Ala?Arg?Arg?Ser?Gly?Pro?Leu?Pro?Ala?Thr?Pro?Thr?Val?Glu?Pro?Glu

545 550 555 560

Pro?Glu?Gly?Asp?Glu?Asp?Trp?Pro?Glu?Pro?Ile?Asn?Pro?Ala?Gly?Asp

565 570 575

Asn?Lys?Glu?G1u?Ala?Asn?Arg

580

<210>687

<211>1653

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1630)

<223>RXN00595

<400>687

cgacgacacc?cggtccatcg?aaccagatga?cgatcaatcg?cctttgacta?ctagcgctcg?60

ttcagtcacc?aacccaacag?atcaggagga?taaagcttaa?atg?gcc?atg?gat?gtt 115

Met?Ala?Met?Asp?Val

1 5

ctc?ctt?cct?att?ttc?gtt?gca?gtt?ccc?ctt?gct?gcc?tct?gcc?att?gcg 163

Leu?Leu?Pro?Ile?Phe?Val?Ala?Val?Pro?Leu?Ala?Ala?Ser?Ala?Ile?Ala

10 15 20

gtg?ctt?ctg?ccg?tgg?cgt?ctc?atc?cgc?gat?att?ttg?cac?atc?atc?gtg 211

Val?Leu?Leu?Pro?Trp?Arg?Leu?Ile?Arg?Asp?Ile?Leu?His?Ile?Ile?Val

25 30 35

cct?ttc?gcg?ggt?att?ttt?gct?ggc?atc?tgg?ttg?ttt?gca?cac?acc?gct 259

Pro?Phe?Ala?Gly?Ile?Phe?Ala?Gly?Ile?Trp?Leu?Phe?Ala?His?Thr?Ala

40 45 50

gaa?cac?ggc?ccg?att?gct?cac?aac?gtg?ggc?ctt?tat?gtc?ggt?ggc?gtg 307

Glu?His?Gly?Pro?Ile?Ala?His?Asn?Val?Gly?Leu?Tyr?Val?Gly?Gly?Val

55 60 65

gca?atc?ccc?ttt?gct?gcc?gat?acg?ttc?agc?gcc?atc?atg?ttg?atc?acc 355

Ala?Ile?Pro?Phe?Ala?Ala?Asp?Thr?Phe?Ser?Ala?Ile?Met?Leu?Ile?Thr

70 75 80 85

acc?tcg?atc?gtt?gcg?gtg?gct?gcc?aac?tgg?ttt?gcc?acc?atc?gtc?ggt 403

Thr?Ser?Ile?Val?Ala?Val?Ala?Ala?Asn?Trp?Phe?Ala?Thr?Ile?Val?Gly

90 95 100

gaa?acc?cgc?gcg?cgt?ttc?tat?cca?gcg?ctc?aca?ttg?atg?ctg?atc?acg 451

Glu?Thr?Arg?Ala?Arg?Phe?Tyr?Pro?Ala?Leu?Thr?Leu?Met?Leu?Ile?Thr

105 110 115

ggc?gtc?aac?ggt?gct?ctg?ctg?act?gcc?gat?ctg?ttc?aac?ttc?ttt?gtg 499

Gly?Val?Asn?Gly?Ala?Leu?Leu?Thr?Ala?Asp?Leu?Phe?Asn?Phe?Phe?Val

120 125 130

ttc?atc?gaa?gtg?atg?ctg?ctg?cct?tcc?tat?ggt?ttg?atc?gcc?atg?acc 547

Phe?Ile?Glu?Val?Met?Leu?Leu?Pro?Ser?Tyr?Gly?Leu?Ile?Ala?Met?Thr

135 140 145

gga?acg?tgg?gcg?cgc?cta?gcc?tct?gga?cga?atc?ttc?gta?cta?gtc?aat 595

Gly?Thr?Trp?Ala?Arg?Leu?Ala?Ser?Gly?Arg?Ile?Phe?Val?Leu?Val?Asn

150 155 160 165

ctc?tct?gcc?tcc?aca?ttg?ctg?gtt?gca?ggt?gtg?gga?atc?gtc?tac?ggt 643

Leu?Ser?Ala?Ser?Thr?Leu?Leu?Val?Ala?Gly?Val?Gly?Ile?Val?Tyr?Gly

170 175 180

gtc?ata?ggc?tca?gtc?aac?atc?gca?gct?ctg?caa?gat?gtc?gta?gag?ggc 691

Val?Ile?Gly?Ser?Val?Asn?Ile?Ala?Ala?Leu?Gln?Asp?Val?Val?Glu?Gly

185 190 195

aac?ccc?ctg?gtt?gcc?agc?gca?atg?ggc?atc?gtg?gtt?att?gcc?atc?gcg 739

Asn?Pro?Leu?Val?Ala?Ser?Ala?Met?Gly?Ile?Val?Val?Ile?Ala?Ile?Ala

200 205 210

gtt?aaa?gcc?ggt?gta?ttc?cca?gtg?cac?aca?tgg?ctg?cca?cgc?acc?tat 787

Val?Lys?Ala?Gly?Val?Phe?Pro?Val?His?Thr?Trp?Leu?Pro?Arg?Thr?Tyr

215 220 225

cct?ggt?aca?tca?gca?gct?gtg?atg?ggg?ttg?ttc?tcc?ggt?ttg?cac?acc 835

Pro?Gly?Thr?Ser?Ala?Ala?Val?Met?Gly?Leu?Phe?Ser?Gly?Leu?His?Thr

230 235 240 245

aaa?gtc?gcg?gta?tac?atg?ctc?tat?cgc?att?tgg?gtc?cac?att?ttt?aac 883

Lys?Val?Ala?Val?Tyr?Met?Leu?Tyr?Arg?Ile?Trp?Val?His?Ile?Phe?Asn

250 255 260

atg?gat?ccc?acg?tgg?aat?tgg?ctg?att?gtc?gca?ttc?atg?gtg?ata?tcc 931

Met?Asp?Pro?Thr?Trp?Asn?Trp?Leu?Ile?Val?Ala?Phe?Met?Val?Ile?Ser

265 270 275

atg?ctg?gtc?ggt?ggc?ttc?gct?gga?ctt?gct?gaa?aac?tcc?atc?cgt?cgc 979

Met?Leu?Val?Gly?Gly?Phe?Ala?Gly?Leu?Ala?Glu?Asn?Ser?Ile?Arg?Arg

280 285 290

gtc?ctt?gcc?tac?caa?atg?gtc?aac?ggc?atg?cca?ttt?att?ctc?atc?atg 1027

Val?Leu?Ala?Tyr?Gln?Met?Val?Asn?Gly?Met?Pro?Phe?Ile?Leu?Ile?Met

295 300 305

atg?gcg?ttt?acc?tct?gac?gat?cca?cag?cgc?gca?ctt?gcc?gct?ggt?ctg 1075

Met?Ala?Phe?Thr?Ser?Asp?Asp?Pro?Gln?Arg?Ala?Leu?Ala?Ala?Gly?Leu

310 315 320 325

ttg?tac?acc?ctg?cac?cac?atg?atc?acc?atc?gcc?gca?ttg?gtg?ctc?act 1123

Leu?Tyr?Thr?Leu?His?His?Met?Ile?Thr?Ile?Ala?Ala?Leu?Val?Leu?Thr

330 335 340

tcc?ggc?gca?atc?gaa?gaa?acc?tac?ggc?acc?ggt?atg?ttg?tcc?aag?ctg 1171

Ser?Gly?Ala?Ile?Glu?Glu?Thr?Tyr?Gly?Thr?Gly?Met?Leu?Ser?Lys?Leu

345 350 355

tct?ggc?ctt?gca?cgc?cgc?gaa?ccc?gtc?gtc?gca?gca?gtg?ttc?gct?gca 1219

Ser?Gly?Leu?Ala?Arg?Arg?Glu?Pro?Val?Val?Ala?Ala?Val?Phe?Ala?Ala

360 365 370

ggt?gcc?ttc?tct?gtt?gtc?ggt?ttc?cca?ccg?ttt?tcc?ggt?atg?tgg?ggc 1267

Gly?Ala?Phe?Ser?Val?Val?Gly?Phe?Pro?Pro?Phe?Ser?Gly?Met?Trp?Gly

375 380 385

aaa?gcg?ctc?atc?ctg?ctc?gag?atc?gcc?cgc?gtc?ggc?aat?att?gca?gca 1315

Lys?Ala?Leu?Ile?Leu?Leu?Glu?Ile?Ala?Arg?Val?Gly?Asn?Ile?Ala?Ala

390 395 400 405

tgg?atc?gca?atc?gcc?gcc?atc?atc?atc?gcc?agc?ctg?ggc?gca?ctg?ctc 1363

Trp?Ile?Ala?Ile?Ala?Ala?Ile?Ile?Ile?Ala?Ser?Leu?Gly?Ala?Leu?Leu

410 415 420

tcg?atg?atc?cgc?gtg?tgg?cgt?gaa?gtc?ttc?tgg?ggt?ggc?gca?atg?cac 1411

Ser?Met?Ile?Arg?Val?Trp?Arg?Glu?Val?Phe?Trp?Gly?Gly?Ala?Met?His

425 430 435

cag?cgc?ggc?gtc?tcg?ccg?cag?ctg?cgc?atc?agc?cca?gca?aaa?atc?gcc 1459

Gln?Arg?Gly?Val?Ser?Pro?Gln?Leu?Arg?Ile?Ser?Pro?Ala?Lys?Ile?Ala

440 445 450

cca?gcg?ctc?agc?ctg?atc?att?tta?tcg?gta?ggc?atg?ttc?atc?ttc?gcg 1507

Pro?Ala?Leu?Ser?Leu?Ile?Ile?Leu?Ser?Val?Gly?Met?Phe?Ile?Phe?Ala

455 460 465

ggc?ccg?ctt?atc?gac?gcg?acc?ctc?acc?gcc?acc?gac?ggc?ctc?ttg?aac 1555

Gly?Pro?Leu?Ile?Asp?Ala?Thr?Leu?Thr?Ala?Thr?Asp?Gly?Leu?Leu?Asn

470 475 480 485

acc?gat?gca?tac?caa?cag?gct?gtg?ctc?ggt?gaa?aat?gcc?atc?gga?gtg 1603

Thr?Asp?Ala?Tyr?Gln?Gln?Ala?Val?Leu?Gly?Glu?Asn?Ala?Ile?Gly?Val

490 495 500

cca?agc?cct?agc?tac?cag?gga?gga?aac?taatgcttaa?cgccctgaaa 1650

Pro?Ser?Pro?Ser?Tyr?Gln?Gly?Gly?Asn

505 510

ttc 1653

<210>688

<211>510

<212>PRT

＜213〉Corynebacterium glutamicum

<400>688

Met?Ala?Met?Asp?Val?Leu?Leu?Pro?Ile?Phe?Val?Ala?Val?Pro?Leu?Ala

1 5 l0 15

Ala?Ser?Ala?Ile?Ala?Val?Leu?Leu?Pro?Trp?Arg?Leu?Ile?Arg?Asp?Ile

20 25 30

Leu?His?Ile?Ile?Val?Pro?Phe?Ala?Gly?Ile?Phe?Ala?Gly?Ile?Trp?Leu

35 40 45

Phe?Ala?His?Thr?Ala?Glu?His?Gly?Pro?Ile?Ala?His?Asn?Val?Gly?Leu

50 55 60

Tyr?Val?Gly?Gly?Val?Ala?Ile?Pro?Phe?Ala?Ala?Asp?Thr?Phe?Ser?Ala

65 70 75 80

Ile?Met?Leu?Ile?Thr?Thr?Ser?Ile?Val?Ala?Val?Ala?Ala?Asn?Trp?Phe

85 90 95

Ala?Thr?Ile?Val?Gly?Glu?Thr?Arg?Ala?Arg?Phe?Tyr?Pro?Ala?Leu?Thr

100 105 110

Leu?Met?Leu?Ile?Thr?Gly?Val?Asn?Gly?Ala?Leu?Leu?Thr?Ala?Asp?Leu

115 120 125

Phe?Asn?Phe?Phe?Val?Phe?Ile?Glu?Val?Met?Leu?Leu?Pro?Ser?Tyr?Gly

130 135 140

Leu?Ile?Ala?Met?Thr?Gly?Thr?Trp?Ala?Arg?Leu?Ala?Ser?Gly?Arg?Ile

145 150 155 160

Phe?Val?Leu?Val?Asn?Leu?Ser?Ala?Ser?Thr?Leu?Leu?Val?Ala?Gly?Val

165 170 175

Gly?Ile?Val?Tyr?Gly?Val?Ile?Gly?Ser?Val?Asn?Ile?Ala?Ala?Leu?Gln

180 185 190

Asp?Val?Val?Glu?Gly?Asn?Pro?Leu?Val?Ala?Ser?Ala?Met?Gly?Ile?Val

195 200 205

Val?Ile?Ala?Ile?Ala?Val?Lys?Ala?Gly?Val?Phe?Pro?Val?His?Thr?Trp

210 215 220

Leu?Pro?Arg?Thr?Tyr?Pro?Gly?Thr?Ser?Ala?Ala?Val?Met?Gly?Leu?Phe

225 230 235 240

Ser?Gly?Leu?His?Thr?Lys?Val?Ala?Val?Tyr?Met?Leu?Tyr?Arg?Ile?Trp

245 250 255

Val?His?Ile?Phe?Asn?Met?Asp?Pro?Thr?Trp?Asn?Trp?Leu?Ile?Val?Ala

260 265 270

Phe?Met?Val?Ile?Ser?Met?Leu?Val?Gly?Gly?Phe?Ala?Gly?Leu?Ala?Glu

275 280 285

Asn?Ser?Ile?Arg?Arg?Val?Leu?Ala?Tyr?Gln?Met?Val?Asn?Gly?Met?Pro

290 295 300

Phe?Ile?Leu?Ile?Met?Met?Ala?Phe?Thr?Ser?Asp?Asp?Pro?Gln?Arg?Ala

305 310 315 320

Leu?Ala?Ala?Gly?Leu?Leu?Tyr?Thr?Leu?His?His?Met?Ile?Thr?Ile?Ala

325 330 335

Ala?Leu?Val?Leu?Thr?Ser?Gly?Ala?Ile?Glu?Glu?Thr?Tyr?Gly?Thr?Gly

340 345 350

Met?Leu?Ser?Lys?Leu?Ser?Gly?Leu?Ala?Arg?Arg?Glu?Pro?Val?Val?Ala

355 360 365

Ala?Val?Phe?Ala?Ala?Gly?Ala?Phe?Ser?Val?Val?Gly?Phe?Pro?Pro?Phe

370 375 380

Ser?Gly?Met?Trp?Gly?Lys?Ala?Leu?Ile?Leu?Leu?Glu?Ile?Ala?Arg?Val

385 390 395 400

Gly?Asn?Ile?Ala?Ala?Trp?Ile?Ala?Ile?Ala?Ala?Ile?Ile?Ile?Ala?Ser

405 410 415

Leu?Gly?Ala?Leu?Leu?Ser?Met?Ile?Arg?Val?Trp?Arg?Glu?Val?Phe?Trp

420 425 430

Gly?Gly?Ala?Met?His?Gln?Arg?Gly?Val?Ser?Pro?Gln?Leu?Arg?Ile?Ser

435 440 445

Pro?Ala?Lys?Ile?Ala?Pro?Ala?Leu?Ser?Leu?Ile?Ile?Leu?Ser?Val?Gly

450 455 460

Met?Phe?Ile?Phe?Ala?Gly?Pro?Leu?Ile?Asp?Ala?Thr?Leu?Thr?Ala?Thr

465 470 475 480

Asp?Gly?Leu?Leu?Asn?Thr?Asp?Ala?Tyr?Gln?Gln?Ala?Val?Leu?Gly?Glu

485 490 495

Asn?Ala?Ile?Gly?Val?Pro?Ser?Pro?Ser?Tyr?Gln?Gly?Gly?Asn

500 505 510

<210>689

<211>865

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(865)

<223>FRXA00608

<400>689

cgacgacacc?cggtccatcg?aaccagatga?cgatcaatcg?cctttgacta?ctagcgctcg?60

ttcagtcacc?aacccaacag?atcaggagga?taaagcttaa?atg?gcc?atg?gat?gtt 115

Met?Ala?Met?Asp?Val

1 5

ctc?ctt?cct?att?ttc?gtt?gca?gtt?ccc?ctt?gct?gcc?tct?gcc?att?gcg 163

Leu?Leu?Pro?Ile?Phe?Val?Ala?Val?Pro?Leu?Ala?Ala?Ser?Ala?Ile?Ala

10 15 20

gtg?ctt?ctg?ccg?tgg?cgt?ctc?atc?cgc?gat?att?ttg?cac?atc?atc?gtg 211

Val?Leu?Leu?Pro?Trp?Arg?Leu?Ile?Arg?Asp?Ile?Leu?His?Ile?Ile?Val

25 30 35

cct?ttc?gcg?ggt?att?ttt?gct?ggc?atc?tgg?ttg?ttt?gca?cac?acc?gct 259

Pro?Phe?Ala?Gly?Ile?Phe?Ala?Gly?Ile?Trp?Leu?Phe?Ala?His?Thr?Ala

40 45 50

gaa?cac?ggc?ccg?att?gct?cac?aac?gtg?ggc?ctt?tat?gtc?ggt?ggc?gtg 307

Glu?His?Gly?Pro?Ile?Ala?His?Asn?Val?Gly?Leu?Tyr?Val?Gly?Gly?Val

55 60 65

gca?atc?ccc?ttt?gct?gcc?gat?acg?ttc?agc?gcc?atc?atg?ttg?atc?acc 355

Ala?Ile?Pro?Phe?Ala?Ala?Asp?Thr?Phe?Ser?Ala?Ile?Met?Leu?Ile?Thr

70 75 80 85

acc?tcg?atc?gtt?gcg?gtg?gct?gcc?aac?tgg?ttt?gcc?acc?atc?gtc?ggt 403

Thr?Ser?Ile?Val?Ala?Val?Ala?Ala?Asn?Trp?Phe?Ala?Thr?Ile?Val?Gly

90 95 100

gaa?acc?cgc?gcg?cgt?ttc?tat?cca?gcg?ctc?aca?ttg?atg?ctg?atc?acg 451

Glu?Thr?Arg?Ala?Arg?Phe?Tyr?Pro?Ala?Leu?Thr?Leu?Met?Leu?Ile?Thr

105 110 115

ggc?gtc?aac?ggt?gct?ctg?ctg?act?gcc?gat?ctg?ttc?aac?ttc?ttt?gtg 499

Gly?Val?Asn?Gly?Ala?Leu?Leu?Thr?Ala?Asp?Leu?Phe?Asn?Phe?Phe?Val

120 125 130

ttc?atc?gaa?gtg?atg?ctg?ctg?cct?tcc?tat?ggt?ttg?atc?gcc?atg?acc 547

Phe?Ile?Glu?Val?Met?Leu?Leu?Pro?Ser?Tyr?Gly?Leu?Ile?Ala?Met?Thr

135 140 145

gga?acg?tgg?gcg?cgc?cta?gcc?tct?gga?cga?atc?ttc?gta?cta?gtc?aat 595

Gly?Thr?Trp?Ala?Arg?Leu?Ala?Ser?Gly?Arg?Ile?Phe?Val?Leu?Val?Asn

150 155 160 165

ctc?tct?gcc?tcc?aca?ttg?ctg?gtt?gca?ggt?gtg?gga?atc?gtc?tac?ggt 643

Leu?Ser?Ala?Ser?Thr?Leu?Leu?Val?Ala?Gly?Val?Gly?Ile?Val?Tyr?Gly

170 175 180

gtc?ata?ggc?tca?gtc?aac?atc?gca?gct?ctg?caa?gat?gtc?gta?gag?ggc 691

Val?Ile?Gly?Ser?Val?Asn?Ile?Ala?Ala?Leu?Gln?Asp?Val?Val?Glu?Gly

185 190 195

aac?ccc?ctg?gtt?gcc?agc?gca?atg?ggc?atc?gtg?gtt?att?gcc?atc?gcg 739

Asn?Pro?Leu?Val?Ala?Ser?Ala?Met?Gly?Ile?Val?Val?Ile?Ala?Ile?Ala

200 205 210

gtt?aaa?gcc?ggt?gta?ttc?cca?gtg?cac?aca?tgg?ctg?cca?cgc?acc?tat 787

Val?Lys?Ala?Gly?Val?Phe?Pro?Val?His?Thr?Trp?Leu?Pro?Arg?Thr?Tyr

215 220 225

cct?ggt?aca?tca?gca?gct?gtg?atg?ggg?ttg?ttc?tcc?ggt?ttg?cac?acc 835

Pro?Gly?Thr?Ser?Ala?Ala?Val?Met?Gly?Leu?Phe?Ser?Gly?Leu?His?Thr

230 235 240 245

aaa?gtc?gcg?gta?tac?atg?ctc?tat?cgc?att 865

Lys?Val?Ala?Val?Tyr?Met?Leu?Tyr?Arg?Ile

250 255

<210>690

<211>255

<212>PRT

＜213〉Corynebacterium glutamicum

<400>690

Met?Ala?Met?Asp?Val?Leu?Leu?Pro?Ile?Phe?Val?Ala?Val?Pro?Leu?Ala

1 5 10 15

Ala?Ser?Ala?Ile?Ala?Val?Leu?Leu?Pro?Trp?Arg?Leu?Ile?Arg?Asp?Ile

20 25 30

Leu?His?Ile?Ile?Val?Pro?Phe?Ala?Gly?Ile?Phe?Ala?Gly?Ile?Trp?Leu

35 40 45

Phe?Ala?His?Thr?Ala?Glu?His?Gly?Pro?Ile?Ala?His?Asn?Val?Gly?Leu

50 55 60

Tyr?Val?Gly?Gly?Val?Ala?Ile?Pro?Phe?Ala?Ala?Asp?Thr?Phe?Ser?Ala

65 70 75 80

Ile?Met?Leu?Ile?Thr?Thr?Ser?Ile?Val?Ala?Val?Ala?Ala?Asn?Trp?Phe

85 90 95

Ala?Thr?Ile?Val?Gly?Glu?Thr?Arg?Ala?Arg?Phe?Tyr?Pro?Ala?Leu?Thr

100 105 110

Leu?Met?Leu?Ile?Thr?Gly?Val?Asn?Gly?Ala?Leu?Leu?Thr?Ala?Asp?Leu

115 120 125

Phe?Asn?Phe?Phe?Val?Phe?Ile?Glu?Val?Met?Leu?Leu?Pro?Ser?Tyr?Gly

130 135 140

Leu?Ile?Ala?Met?Thr?Gly?Thr?Trp?Ala?Arg?Leu?Ala?Ser?Gly?Arg?Ile

145 150 155 160

Phe?Val?Leu?Val?Asn?Leu?Ser?Ala?Ser?Thr?Leu?Leu?Val?Ala?Gly?Val

165 170 175

Gly?Ile?Val?Tyr?Gly?Val?Ile?Gly?Ser?Val?Asn?Ile?Ala?Ala?Leu?Gln

180 185 190

Asp?Val?Val?Glu?Gly?Asn?Pro?Leu?Val?Ala?Ser?Ala?Met?Gly?Ile?Val

195 200 205

Val?Ile?Ala?Ile?Ala?Val?Lys?Ala?Gly?Val?Phe?Pro?Val?His?Thr?Trp

210 215 220

Leu?Pro?Arg?Thr?Tyr?Pro?Gly?Thr?Ser?Ala?Ala?Val?Met?Gly?Leu?Phe

225 230 235 240

Ser?Gly?Leu?His?Thr?Lys?Val?Ala?Val?Tyr?Met?Leu?Tyr?Arg?Ile

245 250 255

<210>691

<211>2118

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(2118)

<223>RXA00913

<400>691

att?att?tcc?gtg?gtg?ggc?att?ggt?acc?cgc?gaa?gct?ttg?ctg?gca?ggt 48

Ile?Ile?Ser?Val?Val?Gly?Ile?Gly?Thr?Arg?Glu?Ala?Leu?Leu?Ala?Gly

1 5 10 15

ctt?gca?ctg?acc?gtt?gcg?cac?tcc?ttg?ttt?aag?gca?aca?ttg?ttc?atg 96

Leu?Ala?Leu?Thr?Val?Ala?His?Ser?Leu?Phe?Lys?Ala?Thr?Leu?Phe?Met

20 25 30

aca?gtt?ggt?gcc?att?gac?cac?acc?acc?gga?act?cgt?gat?att?cgt?aaa 144

Thr?Val?Gly?Ala?Ile?Asp?His?Thr?Thr?Gly?Thr?Arg?Asp?Ile?Arg?Lys

35 40 45

ctc?tcc?ggt?ctg?tgg?cgt?aaa?caa?ccg?atc?ctg?ttc?gcc?gtt?gct?gct 192

Leu?Ser?Gly?Leu?Trp?Arg?Lys?Gln?Pro?Ile?Leu?Phe?Ala?Val?Ala?Ala

50 55 60

gtt?tcg?gcg?gcg?tcc?atg?gct?ggt?att?ccg?cca?ctg?ttt?ggt?ttt?atc 240

Val?Ser?Ala?Ala?Ser?Met?Ala?Gly?Ile?Pro?Pro?Leu?Phe?Gly?Phe?Ile

65 70 75 80

gcc?aag?gaa?aca?gcg?ctg?gat?acc?gtg?ttg?aat?gag?cag?atg?ttg?cat 288

Ala?Lys?Glu?Thr?Ala?Leu?Asp?Thr?Val?Leu?Asn?Glu?Gln?Met?Leu?His

85 90 95

ggc?atg?cca?ggt?cga?ttg?atg?ctg?gct?ggc?atc?gtt?ttg?ggt?tcc?atc 336

Gly?Met?Pro?Gly?Arg?Leu?Met?Leu?Ala?Gly?Ile?Val?Leu?Gly?Ser?Ile

100 105 110

ttc?acc?atg?gca?tat?tcc?tgc?tac?ttc?ctg?tac?gaa?gcc?ttt?gcc?acg 384

Phe?Thr?Met?Ala?Tyr?Ser?Cys?Tyr?Phe?Leu?Tyr?Glu?Ala?Phe?Ala?Thr

115 120 125

aag?cac?tcc?aaa?ttc?cca?gag?gcc?aac?ggt?gtc?tca?cct?gca?gtg?gag 432

Lys?His?Ser?Lys?Phe?Pro?Glu?Ala?Asn?Gly?Val?Ser?Pro?Ala?Val?Glu

130 135 140

gca?atg?cat?ccg?gtg?aag?ttt?aag?ctg?tgg?atc?gca?cct?gtc?atc?ctg 480

Ala?Met?His?Pro?Val?Lys?Phe?Lys?Leu?Trp?Ile?Ala?Pro?Val?Ile?Leu

145 150 155 160

gct?att?ttg?acc?gta?gtg?ttt?ggt?gtt?ttc?ccc?aag?cca?gtg?tcg?gaa 528

Ala?Ile?Leu?Thr?Val?Val?Phe?Gly?Val?Phe?Pro?Lys?Pro?Val?Ser?Glu

165 170 175

gca?att?gtc?acg?cat?ctt?gat?aac?gtc?acg?cca?tcg?ctt?gat?gat?gtc 576

Ala?Ile?Val?Thr?His?Leu?Asp?Asn?Val?Thr?Pro?Ser?Leu?Asp?Asp?Val

180 185 190

cac?acc?aaa?ctg?gcc?ttg?tgg?cat?ggt?ctg?aat?cta?ccg?ctg?ctg?ctg 624

His?Thr?Lys?Leu?Ala?Leu?Trp?His?Gly?Leu?Asn?Leu?Pro?Leu?Leu?Leu

195 200 205

tct?gtg?gtg?atc?atc?att?tcc?gga?ttc?atc?atc?ttc?tgg?gag?cga?gac 672

Ser?Val?Val?Ile?Ile?Ile?Ser?Gly?Phe?Ile?Ile?Phe?Trp?Glu?Arg?Asp

210 215 220

acc?gtc?gaa?cgt?ttg?cgc?cct?aac?acc?gca?gcg?ttt?ggc?agt?gcc?gat 720

Thr?Val?Glu?Arg?Leu?Arg?Pro?Asn?Thr?Ala?Ala?Phe?Gly?Ser?Ala?Asp

225 230 235 240

acc?gcc?tac?gac?gcc?att?ctt?gat?gca?ctg?cgt?gtg?ctc?tcc?cac?cgc 768

Thr?Ala?Tyr?Asp?Ala?Ile?Leu?Asp?Ala?Leu?Arg?Val?Leu?Ser?His?Arg

245 250 255

ctg?act?gca?tcc?acc?cag?cgt?ggt?tct?ttg?acc?ctg?aac?gtc?ggt?gtg 816

Leu?Thr?Ala?Ser?Thr?Gln?Arg?Gly?Ser?Leu?Thr?Leu?Asn?Val?Gly?Val

260 265 270

atc?ttc?ttc?gtc?ctc?acg?att?gtt?ccg?ctg?atc?gct?ttg?atc?act?ggc 864

Ile?Phe?Phe?Val?Leu?Thr?Ile?Val?Pro?Leu?Ile?Ala?Leu?Ile?Thr?Gly

275 280 285

gaa?caa?agc?gat?gtc?cgc?atg?gag?ctg?tgg?gat?agc?cct?att?cag?ggc 912

Glu?Gln?Ser?Asp?Val?Arg?Met?Glu?Leu?Trp?Asp?Ser?Pro?Ile?Gln?Gly

290 295 300

ttc?atc?gcg?gcc?atc?att?atc?gtc?gtt?gcg?att?gtg?gca?acc?acc?atg 960

Phe?Ile?Ala?Ala?Ile?Ile?Ile?Val?Val?Ala?Ile?Val?Ala?Thr?Thr?Met

305 310 315 320

gat?aac?cgt?ttg?tct?gcg?ctg?att?ttg?gtg?ggt?gtg?aca?ggt?tat?ggc 1008

Asp?Asn?Arg?Leu?Ser?Ala?Leu?Ile?Leu?Val?Gly?Val?Thr?Gly?Tyr?Gly

325 330 335

att?gcc?gtt?atc?ttc?gcg?cta?cat?ggc?gca?ccg?gac?ttg?gcg?cta?acc 1056

Ile?Ala?Val?Ile?Phe?Ala?Leu?His?Gly?Ala?Pro?Asp?Leu?Ala?Leu?Thr

340 345 350

cag?gtg?ctg?gtg?gag?acc?atc?gtc?atg?gtg?gta?ttc?atg?ctg?gtg?ctg 1104

Gln?Val?Leu?Val?Glu?Thr?Ile?Val?Met?Val?Val?Phe?Met?Leu?Val?Leu

355 360 365

cgt?aaa?atg?ccg?aca?gaa?gtt?gcg?tgg?aag?gca?gaa?cct?aaa?cag?tct 1152

Arg?Lys?Met?Pro?Thr?Glu?Val?Ala?Trp?Lys?Ala?Glu?Pro?Lys?Gln?Ser

370 375 380

cgc?gtg?cga?gcg?tgg?ctt?gct?ggc?gcc?acc?gga?ttg?tcc?gtt?gtt?att 1200

Arg?Val?Arg?Ala?Trp?Leu?Ala?Gly?Ala?Thr?Gly?Leu?Ser?Val?Val?Ile

385 390 395 400

gtc?acc?att?ttt?gcc?atg?aat?gct?cgc?acc?act?gaa?ccg?atc?tct?gta 1248

Val?Thr?Ile?Phe?Ala?Met?Asn?Ala?Arg?Thr?Thr?Glu?Pro?Ile?Ser?Val

405 410 415

tac?atg?cag?gat?ctg?gcc?tat?gag?atc?gga?cat?ggc?gca?aac?acc?gtc 1296

Tyr?Met?Gln?Asp?Leu?Ala?Tyr?Glu?Ile?Gly?His?Gly?Ala?Asn?Thr?Val

420 425 430

aac?gta?ctg?ctc?gta?gac?ctg?cgt?ggt?ttt?gat?acc?ttc?ggt?gaa?att 1344

Asn?Val?Leu?Leu?Val?Asp?Leu?Arg?Gly?Phe?Asp?Thr?Phe?Gly?Glu?Ile

435 440 445

tcc?gtc?ctt?gtg?atc?gcg?gca?acc?ggt?atc?gcc?tcc?ctg?gtc?tac?cga 1392

Ser?Val?Leu?Val?Ile?Ala?Ala?Thr?Gly?Ile?Ala?Ser?Leu?Val?Tyr?Arg

450 455 460

aac?cgc?agc?ttc?cgc?aag?gat?tct?cgc?aga?cca?acc?ctg?gct?acc?act 1440

Asn?Arg?Ser?Phe?Arg?Lys?Asp?Ser?Arg?Arg?Pro?Thr?Leu?Ala?Thr?Thr

465 470 475 480

ggt?cgc?cgt?tgg?ttg?gct?gct?gct?gtt?gat?acc?gaa?agg?gcg?cag?aac 1488

Gly?Arg?Arg?Trp?Leu?Ala?Ala?Ala?Val?Asp?Thr?Glu?Arg?Ala?Gln?Asn

485 490 495

cgc?tcg?ctg?atg?gtt?gat?gtg?gca?acg?cgc?atc?ctc?ttc?cct?gcc?atg 1536

Arg?Ser?Leu?Met?Val?Asp?Val?Ala?Thr?Arg?Ile?Leu?Phe?Pro?Ala?Met

500 505 510

atc?atg?ttg?tct?gtg?tac?ttc?ttc?ttc?gcc?gga?cac?aac?gcg?ccg?ggc 1584

Ile?Met?Leu?Ser?Val?Tyr?Phe?Phe?Phe?Ala?Gly?His?Asn?Ala?Pro?Gly

515 520 525

ggc?gga?ttc?gcc?ggc?ggc?ctt?gtt?gcc?tcc?ttg?gcg?ttc?gcc?ttg?cgc 1632

Gly?Gly?Phe?Ala?Gly?Gly?Leu?Val?Ala?Ser?Leu?Ala?Phe?Ala?Leu?Arg

530 535 540

tac?ctt?gcc?ggt?gga?cgt?gaa?gaa?ctt?gaa?gaa?gcg?ttg?cct?atc?gac 1680

Tyr?Leu?Ala?Gly?Gly?Arg?Glu?Glu?Leu?Glu?Glu?Ala?Leu?Pro?Ile?Asp

545 550 555 560

gcc?ggc?cgt?atc?ttg?gga?act?gga?cta?ttt?gtt?tct?gca?act?gca?gtg 1728

Ala?Gly?Arg?Ile?Leu?Gly?Thr?Gly?Leu?Phe?Val?Ser?Ala?Thr?Ala?Val

565 570 575

ctg?tgg?ccc?atg?gtt?ctt?ctt?ggt?gaa?cca?ccg?ctg?acc?tcc?cat?att 1776

Leu?Trp?Pro?Met?Val?Leu?Leu?Gly?Glu?Pro?Pro?Leu?Thr?Ser?His?Ile

580 585 590

tgg?gat?ctc?aca?ctg?cca?ctt?atc?ggt?gag?att?cac?att?gca?tcc?gcg 1824

Trp?Asp?Leu?Thr?Leu?Pro?Leu?Ile?Gly?Glu?Ile?His?Ile?Ala?Ser?Ala

595 600 605

ctg?ctc?ttt?gac?ctt?ggt?gtc?tac?ctg?atc?gtc?atc?ggt?ttg?acc?atg 1872

Leu?Leu?Phe?Asp?Leu?Gly?Val?Tyr?Leu?Ile?Val?Ile?Gly?Leu?Thr?Met

610 615 620

cac?att?ctc?aac?agt?ttg?ggc?ggc?cag?ctc?gac?cgc?gat?gag?gaa?atg 1920

His?Ile?Leu?Asn?Ser?Leu?Gly?Gly?Gln?Leu?Asp?Arg?Asp?Glu?Glu?Met

625 630 635 640

cgt?aag?cag?cgt?gcg?cgc?gac?cga?gct?cga?cgc?ttg?gcg?cgc?aac?cag 1968

Arg?Lys?Gln?Arg?Ala?Arg?Asp?Arg?Ala?Arg?Arg?Leu?Ala?Arg?Asn?Gln

645 650 655

cgt?cga?gaa?gca?gca?acc?gtc?ggc?gca?cgc?agg?tcg?aac?gag?aaa?tcg 2016

Arg?Arg?Glu?Ala?Ala?Thr?Val?Gly?Ala?Arg?Arg?Ser?Asn?Glu?Lys?Ser

660 665 670

aca?cgc?caa?atg?ccg?acg?att?cgg?cct?cca?ggg?gca?gac?aca?gaa?tcg 2064

Thr?Arg?Gln?Met?Pro?Thr?Ile?Arg?Pro?Pro?Gly?Ala?Asp?Thr?Glu?Ser

675 680 685

gtg?gag?cag?aac?ggt?gag?aac?cag?acg?tcg?ata?agc?aca?aag?cgt?tta 2112

Val?Glu?Gln?Asn?Gly?Glu?Asn?Gln?Thr?Ser?Ile?Ser?Thr?Lys?Arg?Leu

690 695 700

aag?cag 2118

Lys?Gln

705

<210>692

<211>706

<212>PRT

＜213〉Corynebacterium glutamicum

<400>692

Ile?Ile?Ser?Val?Val?Gly?Ile?Gly?Thr?Arg?Glu?Ala?Leu?Leu?Ala?Gly

1 5 10 15

Leu?Ala?Leu?Thr?Val?Ala?His?Ser?Leu?Phe?Lys?Ala?Thr?Leu?Phe?Met

20 25 30

Thr?Val?Gly?Ala?Ile?Asp?His?Thr?Thr?Gly?Thr?Arg?Asp?Ile?Arg?Lys

35 40 45

Leu?Ser?Gly?Leu?Trp?Arg?Lys?Gln?Pro?Ile?Leu?Phe?Ala?Val?Ala?Ala

50 55 60

Val?Ser?Ala?Ala?Ser?Met?Ala?Gly?Ile?Pro?Pro?Leu?Phe?Gly?Phe?Ile

65 70 75 80

Ala?Lys?Glu?Thr?Ala?Leu?Asp?Thr?Val?Leu?Asn?Glu?Gln?Met?Leu?His

85 90 95

Gly?Met?Pro?Gly?Arg?Leu?Met?Leu?Ala?Gly?Ile?Val?Leu?Gly?Ser?Ile

100 105 110

Phe?Thr?Met?Ala?Tyr?Ser?Cys?Tyr?Phe?Leu?Tyr?Glu?Ala?Phe?Ala?Thr

115 120 125

Lys?His?Ser?Lys?Phe?Pro?Glu?Ala?Asn?Gly?Val?Ser?Pro?Ala?Val?Glu

130 135 140

Ala?Met?His?Pro?Val?Lys?Phe?Lys?Leu?Trp?Ile?Ala?Pro?Val?Ile?Leu

145 150 155 160

Ala?Ile?Leu?Thr?Val?Val?Phe?Gly?Val?Phe?Pro?Lys?Pro?Val?Ser?Glu

165 170 175

Ala?Ile?Val?Thr?His?Leu?Asp?Asn?Val?Thr?Pro?Ser?Leu?Asp?Asp?Val

180 185 190

His?Thr?Lys?Leu?Ala?Leu?Trp?His?Gly?Leu?Asn?Leu?Pro?Leu?Leu?Leu

195 200 205

Ser?Val?Val?Ile?Ile?Ile?Ser?Gly?Phe?Ile?Ile?Phe?Trp?Glu?Arg?Asp

210 215 220

Thr?Val?Glu?Arg?Leu?Arg?Pro?Asn?Thr?Ala?Ala?Phe?Gly?Ser?Ala?Asp

225 230 235 240

Thr?Ala?Tyr?Asp?Ala?Ile?Leu?Asp?Ala?Leu?Arg?Val?Leu?Ser?His?Arg

245 250 255

Leu?Thr?Ala?Ser?Thr?Gln?Arg?Gly?Ser?Leu?Thr?Leu?Asn?Val?Gly?Val

260 265 270

Ile?Phe?Phe?Val?Leu?Thr?Ile?Val?Pro?Leu?Ile?Ala?Leu?Ile?Thr?Gly

275 280 285

Glu?Gln?Ser?Asp?Val?Arg?Met?Glu?Leu?Trp?Asp?Ser?Pro?Ile?Gln?Gly

290 295 300

Phe?Ile?Ala?Ala?Ile?Ile?Ile?Val?Val?Ala?Ile?Val?Ala?Thr?Thr?Met

305 310 315 320

Asp?Asn?Arg?Leu?Ser?Ala?Leu?Ile?Leu?Val?Gly?Val?Thr?Gly?Tyr?Gly

325 330 335

Ile?Ala?Val?Ile?Phe?Ala?Leu?His?Gly?Ala?Pro?Asp?Leu?Ala?Leu?Thr

340 345 350

Gln?Val?Leu?Val?Glu?Thr?Ile?Val?Met?Val?Val?Phe?Met?Leu?Val?Leu

355 360 365

Arg?Lys?Met?Pro?Thr?Glu?Val?Ala?Trp?Lys?Ala?Glu?Pro?Lys?Gln?Ser

370 375 380

Arg?Val?Arg?Ala?Trp?Leu?Ala?Gly?Ala?Thr?Gly?Leu?Ser?Val?Val?Ile

385 390 395 400

Val?Thr?Ile?Phe?Ala?Met?Asn?Ala?Arg?Thr?Thr?Glu?Pro?Ile?Ser?Val

405 410 415

Tyr?Met?Gln?Asp?Leu?Ala?Tyr?Glu?Ile?Gly?His?Gly?Ala?Asn?Thr?Val

420 425 430

Asn?Val?Leu?Leu?Val?Asp?Leu?Arg?Gly?Phe?Asp?Thr?Phe?Gly?Glu?Ile

435 440 445

Ser?Val?Leu?Val?Ile?Ala?Ala?Thr?Gly?Ile?Ala?Ser?Leu?Val?Tyr?Arg

450 455 460

Asn?Arg?Ser?Phe?Arg?Lys?Asp?Ser?Arg?Arg?Pro?Thr?Leu?Ala?Thr?Thr

465 470 475 480

Gly?Arg?Arg?Trp?Leu?Ala?Ala?Ala?Val?Asp?Thr?Glu?Arg?Ala?Gln?Asn

485 490 495

Arg?Ser?Leu?Met?Val?Asp?Val?Ala?Thr?Arg?Ile?Leu?Phe?Pro?Ala?Met

500 505 510

Ile?Met?Leu?Ser?Val?Tyr?Phe?Phe?Phe?Ala?Gly?His?Asn?Ala?Pro?Gly

515 520 525

Gly?Gly?Phe?Ala?Gly?Gly?Leu?Val?Ala?Ser?Leu?Ala?Phe?Ala?Leu?Arg

530 535 540

Tyr?Leu?Ala?Gly?Gly?Arg?Glu?Glu?Leu?Glu?Glu?Ala?Leu?Pro?Ile?Asp

545 550 555 560

Ala?Gly?Arg?Ile?Leu?Gly?Thr?Gly?Leu?Phe?Val?Ser?Ala?Thr?Ala?Val

565 570 575

Leu?Trp?Pro?Met?Val?Leu?Leu?Gly?Glu?Pro?Pro?Leu?Thr?Ser?His?Ile

580 585 590

Trp?Asp?Leu?Thr?Leu?Pro?Leu?Ile?Gly?Glu?Ile?His?Ile?Ala?Ser?Ala

595 600 605

Leu?Leu?Phe?Asp?Leu?Gly?Val?Tyr?Leu?Ile?Val?Ile?Gly?Leu?Thr?Met

610 615 620

His?Ile?Leu?Asn?Ser?Leu?Gly?Gly?Gln?Leu?Asp?Arg?Asp?Glu?Glu?Met

625 630 635 640

Arg?Lys?Gln?Arg?Ala?Arg?Asp?Arg?Ala?Arg?Arg?Leu?Ala?Arg?Asn?Gln

645 650 655

Arg?Arg?Glu?Ala?Ala?Thr?Val?Gly?Ala?Arg?Arg?Ser?Asn?Glu?Lys?Ser

660 665 670

Thr?Arg?Gln?Met?Pro?Thr?Ile?Arg?Pro?Pro?Gly?Ala?Asp?Thr?Glu?Ser

675 680 685

Val?Glu?Gln?Asn?Gly?Glu?Asn?Gln?Thr?Ser?Ile?Ser?Thr?Lys?Arg?Leu

690 695 700

Lys?Gln

705

<210>693

<211>955

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(955)

<223>RXA00909

<400>693

tcgatgtgtg?ttgctaactg?ggggtggcac?gcacgttggc?gttgttgttt?ggtgtggctc?60

cagagtaatc?cacaacgcgc?aaaggggaac?tggagaacac?gtg?ctc?att?ctt?ttt 115

Val?Leu?Ile?Leu?Phe

1 5

ctc?gcg?ctc?act?gca?gcc?gca?gta?gtc?gcc?ccc?atc?ctg?atc?cga?act 163

Leu?Ala?Leu?Thr?Ala?Ala?Ala?Val?Val?Ala?Pro?Ile?Leu?Ile?Arg?Thr

10 15 20

ctc?ggt?cga?cca?gct?ttt?ggt?ctg?ctg?gcg?ctt?gta?cct?ggc?att?ggt 211

Leu?Gly?Arg?Pro?Ala?Phe?Gly?Leu?Leu?Ala?Leu?Val?Pro?Gly?Ile?Gly

25 30 35

ttt?ttc?tgg?gtg?ctt?tcg?gag?ttc?atc?aaa?ggc?act?ttc?aag?gat?gga 259

Phe?Phe?Trp?Val?Leu?Ser?Glu?Phe?Ile?Lys?Gly?Thr?Phe?Lys?Asp?Gly

40 45 50

ggt?gaa?ctc?ctc?ctc?cac?tat?gcc?tgg?atg?cct?tcg?gct?cac?ctc?aat 307

Gly?Glu?Leu?Leu?Leu?His?Tyr?Ala?Trp?Met?Pro?Ser?Ala?His?Leu?Asn

55 60 65

atc?gat?ttc?cgt?atg?gat?tcc?ctc?gcg?gcg?ctg?ttc?tca?ctc?atc?gtc 355

Ile?Asp?Phe?Arg?Met?Asp?Ser?Leu?Ala?Ala?Leu?Phe?Ser?Leu?Ile?Val

70 75 80 85

tta?ggc?gtg?ggc?gcc?cta?gtg?ctg?ctg?tac?tgc?tgg?gga?tat?ttt?gat 403

Leu?Gly?Val?Gly?Ala?Leu?Val?Leu?Leu?Tyr?Cys?Trp?Gly?Tyr?Phe?Asp

90 95 100

tcc?aac?gcg?ggt?cgc?ctc?agt?gcc?ttt?ggt?gct?gaa?ctg?gtg?gcc?ttc 451

Ser?Asn?Ala?Gly?Arg?Leu?Ser?Ala?Phe?Gly?Ala?Glu?Leu?Val?Ala?Phe

105 110 115

gcc?atg?gcg?atg?ttt?ggt?ctt?gtc?att?tca?gac?aac?atc?ctg?ctg?atg 499

Ala?Met?Ala?Met?Phe?Gly?Leu?Val?Ile?Ser?Asp?Asn?Ile?Leu?Leu?Met

120 125 130

tac?gtc?ttc?tgg?gaa?atc?acc?tcc?gtt?tta?tcc?ttc?ctc?ctg?gtt?ggt 547

Tyr?Val?Phe?Trp?Glu?Ile?Thr?Ser?Val?Leu?Ser?Phe?Leu?Leu?Val?Gly

135 140 145

tat?tac?ggc?gaa?cgc?gca?tct?tca?cgt?cgc?tct?gca?ggt?caa?gcc?ttg 595

Tyr?Tyr?Gly?Glu?Arg?Ala?Ser?Ser?Arg?Arg?Ser?Ala?Gly?Gln?Ala?Leu

150 155 160 165

atg?gtg?acc?acc?ctg?ggt?gga?ttg?gcc?atg?ctg?gtg?ggc?atc?att?ttg 643

Met?Val?Thr?Thr?Leu?Gly?Gly?Leu?Ala?Met?Leu?Val?Gly?Ile?Ile?Leu

170 175 180

atg?ggt?acc?caa?act?ggc?gtg?tgg?cga?ttc?tct?gag?atc?cct?gcc?tac 691

Met?Gly?Thr?Gln?Thr?Gly?Val?Trp?Arg?Phe?Ser?Glu?Ile?Pro?Ala?Tyr

185 190 195

tca?agc?tcc?tgg?gca?gat?gtg?ccg?tat?att?tcc?gct?gct?gct?gcc?ctt 739

Ser?Ser?Ser?Trp?Ala?Asp?Val?Pro?Tyr?Ile?Ser?Ala?Ala?Ala?Ala?Leu

200 205 210

atc?ttg?gct?ggc?gca?cta?tcc?aaa?tcg?gct?atc?gca?cca?acc?cac?ttc 787

Ile?Leu?Ala?Gly?Ala?Leu?Ser?Lys?Ser?Ala?Ile?Ala?Pro?Thr?His?Phe

215 220 225

tgg?ctt?ccc?ggc?gcg?atg?gcc?gca?cca?acg?ccg?gtg?tct?gct?tac?ctg 835

Trp?Leu?Pro?Gly?Ala?Met?Ala?Ala?Pro?Thr?Pro?Val?Ser?Ala?Tyr?Leu

230 235 240 245

cac?tcc?gca?gcg?atg?gtg?aag?gcg?ggt?att?tac?ctt?gtg?gct?cgc?ctc 883

His?Ser?Ala?Ala?Met?Val?Lys?Ala?Gly?Ile?Tyr?Leu?Val?Ala?Arg?Leu

250 255 260

tct?cca?gac?ctc?aac?gta?gtt?ggt?tcg?tgg?tac?ctg?atc?atc?atc?ccg 931

Ser?Pro?Asp?Leu?Asn?Val?Val?Gly?Ser?Trp?Tyr?Leu?Ile?Ile?Ile?Pro

265 270 275

ttg?ggc?atg?ttg?acc?atg?ctc?atg 955

Leu?Gly?Met?Leu?Thr?Met?Leu?Met

280 285

<210>694

<211>285

<212>PRT

＜213〉Corynebacterium glutamicum

<400>694

Val?Leu?Ile?Leu?Phe?Leu?Ala?Leu?Thr?Ala?Ala?Ala?Val?Val?Ala?Pro

1 5 10 15

Ile?Leu?Ile?Arg?Thr?Leu?Gly?Arg?Pro?Ala?Phe?Gly?Leu?Leu?Ala?Leu

20 25 30

Val?Pro?Gly?Ile?Gly?Phe?Phe?Trp?Val?Leu?Ser?Glu?Phe?Ile?Lys?Gly

35 40 45

Thr?Phe?Lys?Asp?Gly?Gly?Glu?Leu?Leu?Leu?His?Tyr?Ala?Trp?Met?Pro

50 55 60

Ser?Ala?His?Leu?Asn?Ile?Asp?Phe?Arg?Met?Asp?Ser?Leu?Ala?Ala?Leu

65 70 75 80

Phe?Ser?Leu?Ile?Val?Leu?Gly?Val?Gly?Ala?Leu?Val?Leu?Leu?Tyr?Cys

85 90 95

Trp?Gly?Tyr?Phe?Asp?Ser?Asn?Ala?Gly?Arg?Leu?Ser?Ala?Phe?Gly?Ala

100 105 110

Glu?Leu?Val?Ala?Phe?Ala?Met?Ala?Met?Phe?Gly?Leu?Val?Ile?Ser?Asp

115 120 125

Asn?Ile?Leu?Leu?Met?Tyr?Val?Phe?Trp?Glu?Ile?Thr?Ser?Val?Leu?Ser

130 135 140

Phe?Leu?Leu?Val?Gly?Tyr?Tyr?Gly?Glu?Arg?Ala?Ser?Ser?Arg?Arg?Ser

145 150 155 160

Ala?Gly?Gln?Ala?Leu?Met?Val?Thr?Thr?Leu?Gly?Gly?Leu?Ala?Met?Leu

165 170 175

Val?Gly?Ile?Ile?Leu?Met?Gly?Thr?Gln?Thr?Gly?Val?Trp?Arg?Phe?Ser

180 185 190

Glu?Ile?Pro?Ala?Tyr?Ser?Ser?Ser?Trp?Ala?Asp?Val?Pro?Tyr?Ile?Ser

195 200 205

Ala?Ala?Ala?Ala?Leu?Ile?Leu?Ala?Gly?Ala?Leu?Ser?Lys?Ser?Ala?Ile

210 215 220

Ala?Pro?Thr?His?Phe?Trp?Leu?Pro?Gly?Ala?Met?Ala?Ala?Pro?Thr?Pro

225 230 235 240

Val?Ser?Ala?Tyr?Leu?His?Ser?Ala?Ala?Met?Val?Lys?Ala?Gly?Ile?Tyr

245 250 255

Leu?Val?Ala?Arg?Leu?Ser?Pro?Asp?Leu?Asn?Val?Val?Gly?Ser?Trp?Tyr

260 265 270

Leu?Ile?Ile?Ile?Pro?Leu?Gly?Met?Leu?Thr?Met?Leu?Met

275 280 285

<210>695

<211>927

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(904)

<223>RXA00700

<400>695

acgccccaca?agtcgcaaaa?atcaccgccg?gcatccaaga?ggaatcacac?tggctcacag?60

tctcggccgt?gaaagctgcg?ctagggcatg?gtgaaatctc?atg?atc?aac?gcc?atc 115

Met?Ile?Asn?Ala?Ile

1 5

aca?ctc?aag?ccc?aaa?acc?ttc?ctc?acc?tta?agc?ttc?ctt?gcg?gtt?ttg 163

Thr?Leu?Lys?Pro?Lys?Thr?Phe?Leu?Thr?Leu?Ser?Phe?Leu?Ala?Val?Leu

10 15 20

agc?atc?gtg?att?ttc?ttc?tgg?ccg?ctg?atc?gtc?aac?ccg?gaa?tcc?ttc 211

Ser?Ile?Val?Ile?Phe?Phe?Trp?Pro?Leu?Ile?Val?Asn?Pro?Glu?Ser?Phe

25 30 35

ctg?tcc?gac?aaa?gcc?caa?gcg?ccc?ctc?tac?atc?gcg?atc?gtc?att?ccc 259

Leu?Ser?Asp?Lys?Ala?Gln?Ala?Pro?Leu?Tyr?Ile?Ala?Ile?Val?Ile?Pro

40 45 50

ctc?gtg?ctg?gcc?gct?gtc?atc?gcc?gaa?atc?agt?gaa?aac?gga?ttc?gac 307

Leu?Val?Leu?Ala?Ala?Val?Ile?Ala?Glu?Ile?Ser?Glu?Asn?Gly?Phe?Asp

55 60 65

gtt?aaa?gcc?gta?gcc?atg?ctc?ggc?gtc?ctc?acc?gcc?atg?gtt?gcc?gta 355

Val?Lys?Ala?Val?Ala?Met?Leu?Gly?Val?Leu?Thr?Ala?Met?Val?Ala?Val

70 75 80 85

gtc?cga?cca?ttc?ggt?gcc?ggc?gca?gca?ggc?ttt?gaa?gca?gtc?ttc?ttt 403

Val?Arg?Pro?Phe?Gly?Ala?Gly?Ala?Ala?Gly?Phe?Glu?Ala?Val?Phe?Phe

90 95 100

gtc?ctc?atc?ctc?ggc?gga?cga?gcc?ttc?gga?ccc?ggc?ttc?gga?ttc?atc 451

Val?Leu?Ile?Leu?Gly?Gly?Arg?Ala?Phe?Gly?Pro?Gly?Phe?Gly?Phe?Ile

105 110 115

ctc?ggc?aac?acc?gga?ctg?ttc?gca?tcc?gcg?ctg?ctc?acc?gca?gga?atc 499

Leu?Gly?Asn?Thr?Gly?Leu?Phe?Ala?Ser?Ala?Leu?Leu?Thr?Ala?Gly?Ile

120 125 130

gga?ccg?tgg?ctc?ccc?tac?caa?atg?ctc?gca?gcc?gcc?tgg?gtc?agc?ttc 547

Gly?Pro?Trp?Leu?Pro?Tyr?Gln?Met?Leu?Ala?Ala?Ala?Trp?Val?Ser?Phe

135 140 145

ggc?gcc?ggc?eta?ctc?ccc?caa?gta?cgc?ggc?aaa?aag?gaa?atg?ctc?ate 595

Gly?Ala?Gly?Leu?Leu?Pro?Gln?Val?Arg?Gly?Lys?Lys?Glu?Met?Leu?Ile

150 155 160 165

ate?gtc?cta?tac?gcc?atc?gtc?tct?tca?ctc?ggc?tac?gga?ace?atg?atg 643

Ile?Val?Leu?Tyr?Ala?Ile?Val?Ser?Ser?Leu?Gly?Tyr?Gly?Thr?Met?Met

170 175 180

aac?atg?agc?ttc?tgg?ccc?tac?gcc?atc?ggt?gtc?acc?agc?ggg?ctt?tee 691

Asn?Met?Ser?Phe?Trp?Pro?Tyr?Ala?Ile?Gly?Val?Thr?Ser?Gly?Leu?Ser

185 190 195

ttc?aca?ccc?ggc?gcg?ccc?gtc?ctg?gaa?aac?ctc?cac?acc?ttc?atg?ctg 739

Phe?Thr?Pro?Gly?Ala?Pro?Val?Leu?Glu?Asn?Leu?His?Thr?Phe?Met?Leu

200 205 210

ttc?tgc?ctc?acc?aca?tcc?atg?ggt?tgg?gat?ctc?ggc?cgc?gcc?ttc?ttc 787

Phe?Cys?Leu?Thr?Thr?Ser?Met?Gly?Trp?Asp?Leu?GIy?Arg?Ala?Phe?Phe

215 220 225

acc?tca?gtg?cta?tta?ctg?ctc?aca?gcc?aaa?ccc?gtt?tta?ggt?gct?tta 835

Thr?Ser?Val?Leu?Leu?Leu?Leu?Thr?Ala?Lys?Pro?Val?Leu?GIy?Ala?Leu

230 235 240 245

cga?cgc?gcc?agc?cgc?cgc?gcc?gct?ttc?ggc?gtc?gag?cgt?gac?ttc?ggg 883

Arg?Arg?Ala?Ser?Arg?Arg?Ala?Ala?Phe?Gly?Val?Glu?Arg?Asp?Phe?Gly

250 255 260

gag?gcc?ggg?gtg?cct?cgg?gtc?taaagatttt?gttggcttgc?ttc 927

Glu?Ala?Gly?Val?Pro?Arg?Val

265

<210>696

<211>268

<212>PRT

＜213〉Corynebacterium glutamicum

<400>696

Met?Ile?Asn?Ala?Ile?Thr?Leu?Lys?Pro?Lys?Thr?Phe?Leu?Thr?Leu?Ser

1 5 10 15

Phe?Leu?Ala?Val?Leu?Ser?Ile?Val?Ile?Phe?Phe?Trp?Pro?Leu?Ile?Val

20 25 30

Asn?Pro?Glu?Ser?Phe?Leu?Ser?Asp?Lys?Ala?Gln?Ala?Pro?Leu?Tyr?Ile

35 40 45

Ala?Ile?Val?Ile?Pro?Leu?Val?Leu?Ala?Ala?Val?Ile?Ala?Glu?Ile?Ser

50 55 60

Glu?Asn?Gly?Phe?Asp?Val?Lys?Ala?Val?Ala?Met?Leu?Gly?Val?Leu?Thr

65 70 75 80

Ala?Met?Val?Ala?Val?Val?Arg?Pro?Phe?Gly?Ala?Gly?Ala?Ala?Gly?Phe

85 90 95

Glu?Ala?Val?Phe?Phe?Val?Leu?Ile?Leu?Gly?Gly?Arg?Ala?Phe?Gly?Pro

100 105 110

Gly?Phe?Gly?Phe?Ile?Leu?Gly?Asn?Thr?Gly?Leu?Phe?Ala?Ser?Ala?Leu

115 120 125

Leu?Thr?Ala?Gly?Ile?Gly?Pro?Trp?Leu?Pro?Tyr?Gln?Met?Leu?Ala?Ala

130 135 140

Ala?Trp?Val?Ser?Phe?Gly?Ala?Gly?Leu?Leu?Pro?Gln?Val?Arg?Gly?Lys

145 150 155 160

Lys?Glu?Met?Leu?Ile?Ile?Val?Leu?Tyr?Ala?Ile?Val?Ser?Ser?Leu?Gly

165 170 175

Tyr?Gly?Thr?Met?Met?Asn?Met?Ser?Phe?Trp?Pro?Tyr?Ala?Ile?Gly?Val

180 185 190

Thr?Ser?Gly?Leu?Ser?Phe?Thr?Pro?Gly?Ala?Pro?Val?Leu?Glu?Asn?Leu

195 200 205

His?Thr?Phe?Met?Leu?Phe?Cys?Leu?Thr?Thr?Ser?Met?Gly?Trp?Asp?Leu

210 215 220

Gly?Arg?Ala?Phe?Phe?Thr?Ser?Val?Leu?Leu?Leu?Leu?Thr?Ala?Lys?Pro

225 230 235 240

Val?Leu?Gly?Ala?Leu?Arg?Arg?Ala?Ser?Arg?Arg?Ala?Ala?Phe?Gly?Val

245 250 255

Glu?Arg?Asp?Phe?Gly?Glu?Ala?Gly?Val?Pro?Arg?Val

260 265

<210>697

<211>1587

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..<1564)

<223>RXN00483

<400>697

agacccaaga?gtaaaatccc?aggatttgct?tatacttgcg?ctcatggata?atcaacttcg?60

tcccactttg?cattatcaag?ctcaaaaccc?gcaccggcga?gtg?ctg?gtc?acc?ggt 115

Val?Leu?Val?Thr?Gly

1 5

gcg?aca?ggc?tac?att?ggc?ggc?agg?ttg?att?act?gag?tta?ctt?gct?gcc 163

Ala?Thr?Gly?Tyr?Ile?Gly?Gly?Arg?Leu?Ile?Thr?Glu?Leu?Leu?Ala?Ala

10 15 20

ggt?ttc?caa?gtt?cgg?gcc?acc?tcg?agg?aaa?aaa?aca?agt?ctt?cag?cgc 211

Gly?Phe?Gln?Val?Arg?Ala?Thr?Ser?Arg?Lys?Lys?Thr?Ser?Leu?Gln?Arg

25 30 35

ttt?gac?tgg?tac?gag?gac?gtc?gag?gca?gtg?gaa?gcg?gat?ctg?act?gac 259

Phe?Asp?Trp?Tyr?Glu?Asp?Val?Glu?Ala?Val?Glu?Ala?Asp?Leu?Thr?Asp

40 45 50

gcg?act?gag?tta?gat?acg?tta?ttt?aag?gat?gta?gac?gtt?gtt?tac?tat 307

Ala?Thr?Glu?Leu?Asp?Thr?Leu?Phe?Lys?Asp?Val?Asp?Val?Val?Tyr?Tyr

55 60 65

cta?gtg?cat?tcc?atg?gga?ggt?aag?aat?gtt?gat?ttt?gaa?gag?caa?gag 355

Leu?Val?His?Ser?Met?Gly?Gly?Lys?Asn?Val?Asp?Phe?Glu?Glu?Gln?Glu

70 75 80 85

caa?cgc?act?gct?gaa?aat?gta?att?caa?gct?gct?gat?caa?gcc?ggg?ata 403

Gln?Arg?Thr?Ala?Glu?Asn?Val?Ile?Gln?Ala?Ala?Asp?Gln?Ala?Gly?Ile

90 95 100

aaa?cag?att?gtc?tac?ctt?tcc?ggc?tta?cac?ccg?cgt?aat?cga?aaa?ata 451

Lys?Gln?Ile?Val?Tyr?Leu?Ser?Gly?Leu?His?Pro?Arg?Asn?Arg?Lys?Ile

105 110 115

gaa?gaa?cta?tct?aag?cac?atg?cgc?tca?cgg?gaa?aag?gtc?gcc?cag?att 499

Glu?Glu?Leu?Ser?Lys?His?Met?Arg?Ser?Arg?Glu?Lys?Val?Ala?Gin?Ile

120 125 130

ttg?ctg?gca?ggc?cag?aca?cca?gct?tta?att?tta?agg?gct?gcc?aca?att 547

Leu?Leu?Ala?Gly?Gln?Thr?Pro?Ala?Leu?Ile?Leu?Arg?Ala?Ala?Thr?Ile

135 140 145

att?ggt?tcc?ggc?tct?gca?tca?ttt?gaa?ata?atc?cgt?cat?ctc?acg?gag 595

Ile?Gly?Ser?Gly?Ser?Ala?Ser?Phe?Glu?Ile?Ile?Arg?His?Leu?Thr?Glu

150 155 160 165

cgt?ttg?cct?aga?atg?ata?gcg?cct?cag?tgg?att?act?aat?cag?att?gag 643

Arg?Leu?Pro?Arg?Met?Ile?Ala?Pro?Gln?Trp?Ile?Thr?Asn?Gln?Ile?Glu

170 175 180

cct?tta?gca?ata?cgg?gat?gtt?ttg?cat?tac?cta?atc?tcg?gcg?gct?gat 691

Pro?Leu?Ala?Ile?Arg?Asp?Val?Leu?His?Tyr?Leu?Ile?Ser?Ala?Ala?Asp

185 190 195

tta?aag?gat?cea?gtc?aac?cgc?tee?tgc?gat?att?ggg?tgt?gga?aag?tcg 739

Leu?Lys?Asp?Pro?Val?Asn?Arg?Ser?Cys?Asp?Ile?Gly?Cys?Gly?Lys?Ser

200 205 210

tat?gaa?ttt?gcg?gat?cta?ttg?cgt?atc?tat?gcc?gat?gtt?cgg?gga?ctg 787

Tyr?Glu?Phe?Ala?Asp?Leu?Leu?Arg?Ile?Tyr?Ala?Asp?Val?Arg?Gly?Leu

215 220 225

aaa?cgt?cat?gta?aat?tcc?gta?cct?ctc?aat?ttg?ccc?atg?gac?aag?cta 835

Lys?Arg?His?Val?Asn?Ser?Val?Pro?Leu?Asn?Leu?Pro?Met?Asp?Lys?Leu

230 235 240 245

tcc?ggt?ctt?tgg?att?agt?cta?gtg?aca?cct?gtt?cca?ttt?caa?ttg?tct 883

Ser?Gly?Leu?Trp?Ile?Ser?Leu?Val?Thr?Pro?Val?Pro?Phe?Gln?Leu?Ser

250 255 260

ttc?cct?tta?gct?caa?tca?atg?gct?gag?gat?gcc?gtc?act?gaa?gag?cac 931

Phe?Pro?Leu?Ala?Gln?Ser?Met?Ala?Glu?Asp?Ala?Val?Thr?Glu?Glu?His

265 270 275

agc?att?aaa?gat?att?att?tca?gat?cca?ccc?gat?ggt?ttt?att?gag?tat 979

Ser?Ile?Lys?Asp?Ile?Ile?Ser?Asp?Pro?Pro?Asp?Gly?Phe?Ile?Glu?Tyr

280 285 290

cgg?gaa?gca?gtg?gag?ctg?gca?tta?gct?gca?gaa?ttt?gat?cgt?gga?gtt 1027

Arg?Glu?Ala?Val?Glu?Leu?Ala?Leu?Ala?Ala?Glu?Phe?Asp?Arg?Gly?Val

295 300 305

cca?acg?tca?tgg?gat?cga?agc?tgg?act?gta?caa?caa?ccg?tgg?gct?ggc 1075

Pro?Thr?Ser?Trp?Asp?Arg?Ser?Trp?Thr?Val?Gln?Gln?Pro?Trp?Ala?Gly

310 315 320 325

cag?cct?acc?gat?cca?gag?tgg?gcg?ggc?aaa?gct?gta?tat?gaa?gac?gtc 1123

Gln?Pro?Thr?Asp?Pro?Glu?Trp?Ala?Gly?Lys?Ala?Val?Tyr?Glu?Asp?Val

330 335 340

cgc?aca?gaa?gat?act?gat?ctc?cga?gca?gcg?cag?gtc?tgg?ccg?atc?att 1171

Arg?Thr?Glu?Asp?Thr?Asp?Leu?Arg?Ala?Ala?Gln?Val?Trp?Pro?Ile?Ile

345 350 355

gaa?ggt?ttg?ggt?ggc?gtg?aac?ggc?tgg?tat?tct?gca?cca?ctg?cta?tgg 1219

Glu?Gly?Leu?Gly?Gly?Val?Asn?Gly?Trp?Tyr?Ser?Ala?Pro?Leu?Leu?Trp

360 365 370

cga?ttg?cgg?ggt?atc?gct?gac?aga?ctc?atc?ggc?ggt?cca?ggt?ttg?ggc 1267

Arg?Leu?Arg?Gly?Ile?Ala?Asp?Arg?Leu?Ile?Gly?Gly?Pro?Gly?Leu?Gly

375 380 385

gga?cgg?cgg?gat?ccc?cgt?cat?ttg?aaa?ctt?ggg?gat?cgc?att?gat?tgg 1315

Gly?Arg?Arg?Asp?Pro?Arg?His?Leu?Lys?Leu?Gly?Asp?Arg?Ile?Asp?Trp

390 395 400 405

tgg?cgg?gtt?act?gag?atc?gat?cca?cca?cat?aga?tta?gtg?ctc?acc?gca 1363

Trp?Arg?Val?Thr?Glu?Ile?Asp?Pro?Pro?His?Arg?Leu?Val?Leu?Thr?Ala

410 415 420

gag?atg?aaa?gta?gat?ggt?ggc?gct?tgg?ctg?atc?ctg?gaa?gtt?gcg?gac 1411

Glu?Met?Lys?Val?Asp?Gly?Gly?Ala?Trp?Leu?Ile?Leu?Glu?Val?Ala?Asp

425 430 435

aag?gaa?aat?ggc?gga?tgt?act?tat?acc?cag?cgc?gca?ata?ttt?gag?ccg 1459

Lys?Glu?Ash?Gly?Gly?Cys?Thr?Tyr?Thr?Gln?Arg?Ala?Ile?Phe?Glu?Pro

440 445 450

aag?ggt?ttg?ccc?ggt?tat?ctc?tat?tgg?tgg?gtt?gtt?tca?ccg?ttc?cat 1507

Lys?Gly?Leu?Pro?Gly?Tyr?Leu?Tyr?Trp?Trp?Val?Val?Ser?Pro?Phe?His

455 460 465

gcg?att?att?ttt?cct?tat?atg?cgt?tcg?aat?att?tta?aaa?gct?gcg?cgt 1555

Ala?Ile?Ile?Phe?Pro?Tyr?Met?Arg?Ser?Asn?Ile?Leu?Lys?Ala?Ala?Arg

470 475 480 485

aaa?ctc?act?taatcgcaga?gtaggcgtct?aaa 1587

Lys?Leu?Thr

<210>698

<211>488

<212>PRT

＜213〉Corynebacterium glutamicum

<400>698

Val?Leu?Val?Thr?Gly?Ala?Thr?Gly?Tyr?Ile?Gly?Gly?Arg?Leu?Ile?Thr

1 5 10 15

Glu?Leu?Leu?Ala?Ala?Gly?Phe?Gln?Val?Arg?Ala?Thr?Ser?Arg?Lys?Lys

20 25 30

Thr?Ser?Leu?Gln?Arg?Phe?Asp?Trp?Tyr?Glu?Asp?Val?Glu?Ala?Val?Glu

35 40 45

Ala?Asp?Leu?Thr?Asp?Ala?Thr?Glu?Leu?Asp?Thr?Leu?Phe?Lys?Asp?Val

50 55 60

Asp?Val?Val?Tyr?Tyr?Leu?Val?His?Ser?Met?Gly?Gly?Lys?Asn?Val?Asp

65 70 75 80

Phe?Glu?Glu?Gln?Glu?Gln?Arg?Thr?Ala?Glu?Asn?Val?Ile?Gln?Ala?Ala

85 90 95

Asp?Gln?Ala?Gly?Ile?Lys?Gln?Ile?Val?Tyr?Leu?Ser?Gly?Leu?His?Pro

100 105 110

Arg?Asn?Arg?Lys?Ile?Glu?Glu?Leu?Ser?Lys?His?Met?Arg?Ser?Arg?Glu

115 120 125

Lys?Val?Ala?Gln?Ile?Leu?Leu?Ala?Gly?Gln?Thr?Pro?Ala?Leu?Ile?Leu

130 135 140

Arg?Ala?Ala?Thr?Ile?Ile?Gly?Ser?Gly?Ser?Ala?Ser?Phe?Glu?Ile?Ile

145 150 155 160

Arg?His?Leu?Thr?Glu?Arg?Leu?Pro?Arg?Met?Ile?Ala?Pro?Gln?Trp?Ile

165 170 175

Thr?Asn?Gln?Ile?Glu?Pro?Leu?Ala?Ile?Arg?Asp?Val?Leu?His?Tyr?Leu

180 185 190

Ile?Ser?Ala?Ala?Asp?Leu?Lys?Asp?Pro?Val?Asn?Arg?Ser?Cys?Asp?Ile

195 200 205

Gly?Cys?Gly?Lys?Ser?Tyr?Glu?Phe?Ala?Asp?Leu?Leu?Arg?Ile?Tyr?Ala

210 215 220

Asp?Val?Arg?Gly?Leu?Lys?Arg?His?Val?Asn?Ser?Val?Pro?Leu?Asn?Leu

225 230 235 240

Pro?Met?Asp?Lys?Leu?Ser?Gly?Leu?Trp?Ile?Ser?Leu?Val?Thr?Pro?Val

245 250 255

Pro?Phe?Gln?Leu?Ser?Phe?Pro?Leu?Ala?Gln?Ser?Met?Ala?Glu?Asp?Ala

260 265 270

Val?Thr?Glu?Glu?His?Ser?Ile?Lys?Asp?Ile?Ile?Ser?Asp?Pro?Pro?Asp

275 280 285

Gly?Phe?Ile?Glu?Tyr?Arg?Glu?Ala?Val?Glu?Leu?Ala?Leu?Ala?Ala?Glu

290 295 300

Phe?Asp?Arg?Gly?Val?Pro?Thr?Ser?Trp?Asp?Arg?Ser?Trp?Thr?Val?Gln

305 310 315 320

Gln?Pro?Trp?Ala?Gly?Gln?Pro?Thr?Asp?Pro?Glu?Trp?Ala?Gly?Lys?Ala

325 330 335

Val?Tyr?Glu?Asp?Val?Arg?Thr?Glu?Asp?Thr?Asp?Leu?Arg?Ala?Ala?Gln

340 345 350

Val?Trp?Pro?Ile?Ile?Glu?Gly?Leu?Gly?Gly?Val?Asn?Gly?Trp?Tyr?Ser

355 360 365

Ala?Pro?Leu?Leu?Trp?Arg?Leu?Arg?Gly?Ile?Ala?Asp?Arg?Leu?Ile?Gly

370 375 380

Gly?Pro?Gly?Leu?Gly?Gly?Arg?Arg?Asp?Pro?Arg?His?Leu?Lys?Leu?Gly

385 390 395 400

Asp?Arg?Ile?Asp?Trp?Trp?Arg?Val?Thr?Glu?Ile?Asp?Pro?Pro?His?Arg

405 410 415

Leu?Val?Leu?Thr?Ala?Glu?Met?Lys?Val?Asp?Gly?Gly?Ala?Trp?Leu?Ile

420 425 430

Leu?Glu?Val?Ala?Asp?Lys?Glu?Asn?Gly?Gly?Cys?Thr?Tyr?Thr?Gln?Arg

435 440 445

Ala?Ile?Phe?Glu?Pro?Lys?Gly?Leu?Pro?Gly?Tyr?Leu?Tyr?Trp?Trp?Val

450 455 460

Val?Ser?Pro?Phe?His?Ala?Ile?Ile?Phe?Pro?Tyr?Met?Arg?Ser?Asn?Ile

465 470 475 480

Leu?Lys?Ala?Ala?Arg?Lys?Leu?Thr

485

<210>699

<211>1587

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1564)

<223>FRXA00483

<400>699

agacccaaga?gtaaaatccc?aggatttgct?tatacttgcg?ctcatggata?atcaacttcg?60

tcccactttg?cattatcaag?ctcaaaaccc?gcaccggcga?gtg?ctg?gtc?acc?ggt 115

Val?Leu?Val?Thr?Gly

1 5

gcg?aca?ggc?tac?att?ggc?ggc?agg?ttg?att?act?gag?tta?ctt?gct?gcc 163

Ala?Thr?Gly?Tyr?Ile?Gly?Gly?Arg?Leu?Ile?Thr?Glu?Leu?Leu?Ala?Ala

10 15 20

ggt?ttc?caa?gtt?cgg?gcc?acc?tcg?agg?aaa?aaa?aca?agt?ctt?cag?cgc 211

Gly?Phe?Gln?Val?Arg?Ala?Thr?Ser?Arg?Lys?Lys?Thr?Ser?Leu?Gln?Arg

25 30 35

ttt?gac?tgg?tac?gag?gac?gtc?gag?gca?gtg?gaa?gcg?gat?ctg?act?gac 259

Phe?Asp?Trp?Tyr?Glu?Asp?Val?Glu?Ala?Val?Glu?Ala?Asp?Leu?Thr?Asp

40 45 50

gcg?act?gag?tta?gat?acg?tta?ttt?aag?gat?gta?gac?gtt?gtt?tac?tat 307

Ala?Thr?Glu?Leu?Asp?Thr?Leu?Phe?Lys?Asp?Val?Asp?Val?Val?Tyr?Tyr

55 60 65

cta?gtg?cat?tcc?atg?gga?ggt?aag?aat?gtt?gat?ttt?gaa?gag?caa?gag 355

Leu?Val?His?Ser?Met?Gly?Gly?Lys?Asn?Val?Asp?Phe?Glu?Glu?Gln?Glu

70 75 80 85

caa?cgc?act?gct?gaa?aat?gta?att?caa?gct?gct?gat?caa?gcc?ggg?ata 403

Gln?Arg?Thr?Ala?Glu?Asn?Val?Ile?Gln?Ala?Ala?Asp?Gln?Ala?Gly?Ile

90 95 100

aaa?cag?att?gtc?tac?ctt?tcc?ggc?tta?cac?ccg?cgt?aat?cga?aaa?ata 451

Lys?Gln?Ile?Val?Tyr?Leu?Ser?Gly?Leu?His?Pro?Arg?Asn?Arg?Lys?Ile

105 110 115

gaa?gaa?cta?tct?aag?cac?atg?cgc?tca?cgg?gaa?aag?gtc?gcc?cag?att 499

Glu?Glu?Leu?Ser?Lys?His?Met?Arg?Ser?Arg?Glu?Lys?Val?Ala?Gln?Ile

120 125 130

ttg?ctg?gca?ggc?cag?aca?cca?gct?tta?att?tta?agg?gct?gcc?aca?att 547

Leu?Leu?Ala?Gly?Gln?Thr?Pro?Ala?Leu?Ile?Leu?Arg?Ala?Ala?Thr?Ile

135 140 145

att?ggt?tcc?ggc?tct?gca?tca?ttt?gaa?ata?atc?cgt?cat?ctc?acg?gag 595

Ile?Gly?Ser?Gly?Ser?Ala?Ser?Phe?Glu?Ile?Ile?Arg?His?Leu?Thr?Glu

150 155 160 165

cgt?ttg?cct?aga?atg?ata?gcg?cct?cag?tgg?att?act?aat?cag?att?gag 643

Arg?Leu?Pro?Arg?Met?Ile?Ala?Pro?Gln?Trp?Ile?Thr?Asn?Gln?Ile?Glu

170 175 180

cct?tta?gca?ata?cgg?gat?gtt?ttg?cat?tac?cta?atc?tcg?gcg?gct?gat 691

Pro?Leu?Ala?Ile?Arg?Asp?Val?Leu?His?Tyr?Leu?Ile?Ser?Ala?Ala?Asp

185 190 195

tta?aag?gat?cca?gtc?aac?cgc?tcc?tgc?gat?att?ggg?tgt?gga?aag?tcg 739

Leu?Lys?Asp?Pro?Val?Asn?Arg?Ser?Cys?Asp?Ile?Gly?Cys?Gly?Lys?Ser

200 205 210

tat?gaa?ttt?gcg?gat?cta?ttg?cgt?atc?tat?gcc?gat?gtt?cgg?gga?ctg 787

Tyr?Glu?Phe?Ala?Asp?Leu?Leu?Arg?Ile?Tyr?Ala?Asp?Val?Arg?Gly?Leu

215 220 225

aaa?cgt?cat?gta?aat?tcc?gta?cct?ctc?aat?ttg?ccc?atg?gac?aag?cta 835

Lys?Arg?His?Val?Asn?Ser?Val?Pro?Leu?Asn?Leu?Pro?Met?Asp?Lys?Leu

230 235 240 245

tcc?ggt?ctt?tgg?att?agt?cta?gtg?aca?cct?gtt?cca?ttt?caa?ttg?tct 883

Ser?Gly?Leu?Trp?Ile?Ser?Leu?Val?Thr?Pro?Val?Pro?Phe?Gln?Leu?Ser

250 255 260

ttc?cct?tta?gct?caa?tca?atg?gct?gag?gat?gcc?gtc?act?gaa?gag?cac 931

Phe?Pro?Leu?Ala?Gln?Ser?Met?Ala?Glu?Asp?Ala?Val?Thr?Glu?Glu?His

265 270 275

agc?att?aaa?gat?att?att?tca?gat?cca?ccc?gat?ggt?ttt?att?gag?tat 979

Ser?Ile?Lys?Asp?Ile?Ile?Ser?Asp?Pro?Pro?Asp?Gly?Phe?Ile?Glu?Tyr

280 285 290

cgg?gaa?gca?gtg?gag?ctg?gca?tta?gct?gca?gaa?ttt?gat?cgt?gga?gtt 1027

Arg?Glu?Ala?Val?Glu?Leu?Ala?Leu?Ala?Ala?Glu?Phe?Asp?Arg?Gly?Val

295 300 305

cca?acg?tca?tgg?gat?cga?agc?tgg?act?gta?caa?caa?ccg?tgg?gct?ggc 1075

Pro?Thr?Ser?Trp?Asp?Arg?Ser?Trp?Thr?Val?Gln?Gln?Pro?Trp?Ala?Gly

310 315 320 325

cag?cct?acc?gat?cca?gag?tgg?gcg?ggc?aaa?gct?gta?tat?gaa?gac?gtc 1123

Gln?Pro?Thr?Asp?Pro?Glu?Trp?Ala?Gly?Lys?Ala?Val?Tyr?Glu?Asp?Val

330 335 340

cgc?aca?gaa?gat?act?gat?ctc?cga?gca?gcg?cag?gtc?tgg?ccg?atc?att 1171

Arg?Thr?Glu?Asp?Thr?Asp?Leu?Arg?Ala?Ala?Gln?Val?Trp?Pro?Ile?Ile

345 350 355

gaa?ggt?ttg?ggt?ggc?gtg?aac?ggc?tgg?tat?tct?gca?cca?ctg?cta?tgg 1219

Glu?Gly?Leu?Gly?Gly?Val?Asn?Gly?Trp?Tyr?Ser?Ala?Pro?Leu?Leu?Trp

360 365 370

cga?ttg?cgg?ggt?atc?gct?gac?aga?ctc?atc?ggc?ggt?cca?ggt?ttg?ggc 1267

Arg?Leu?Arg?Gly?Ile?Ala?Asp?Arg?Leu?Ile?Gly?Gly?Pro?Gly?Leu?Gly

375 380 385

gga?cgg?cgg?gat?ccc?cgt?cat?ttg?aaa?ctt?ggg?gat?cgc?att?gat?tgg 1315

Gly?Arg?Arg?Asp?Pro?Arg?His?Leu?Lys?Leu?Gly?Asp?Arg?Ile?Asp?Trp

390 395 400 405

tgg?cgg?gtt?act?gag?atc?gat?cca?cca?cat?aga?tta?gtg?ctc?acc?gca 1363

Trp?Arg?Val?Thr?Glu?Ile?Asp?Pro?Pro?His?Arg?Leu?Val?Leu?Thr?Ala

410 415 420

gag?atg?aaa?gta?gat?ggt?ggc?gct?tgg?ctg?atc?ctg?gaa?gtt?gcg?gac 1411

Glu?Met?Lys?Val?Asp?Gly?Gly?Ala?Trp?Leu?Ile?Leu?Glu?Val?Ala?Asp

425 430 435

aag?gaa?aat?ggc?gga?tgt?act?tat?acc?cag?cgc?gca?ata?ttt?gag?ccg 1459

Lys?Glu?Asn?Gly?Gly?Cys?Thr?Tyr?Thr?Gln?Arg?Ala?Ile?Phe?Glu?Pro

440 445 450

aag?ggt?ttg?ccc?ggt?tat?ctc?tat?tgg?tgg?gtt?gtt?tca?ccg?ttc?cat 1507

Lys?Gly?Leu?Pro?Gly?Tyr?Leu?Tyr?Trp?Trp?Val?Val?Ser?Pro?Phe?His

455 460 465

gcg?att?att?ttt?cct?tat?atg?cgt?tcg?aat?att?tta?aaa?gct?gcg?cgt 1555

Ala?Ile?Ile?Phe?Pro?Tyr?Met?Arg?Ser?Asn?Ile?Leu?Lys?Ala?Ala?Arg

470 475 480 485

aaa?ctc?act?taatcgcaga?gtaggcgtct?aaa 1587

Lys?Leu?Thr

<210>700

<211>488

<212>PRT

＜213〉Corynebacterium glutamicum

<400>700

Val?Leu?Val?Thr?Gly?Ala?Thr?Gly?Tyr?Ile?Gly?Gly?Arg?Leu?Ile?Thr

1 5 10 15

Glu?Leu?Leu?Ala?Ala?Gly?Phe?Gln?Val?Arg?Ala?Thr?Ser?Arg?Lys?Lys

20 25 30

Thr?Ser?Leu?Gln?Arg?Phe?Asp?Trp?Tyr?Glu?Asp?Val?Glu?Ala?Val?Glu

35 40 45

Ala?Asp?Leu?Thr?Asp?Ala?Thr?Glu?Leu?Asp?Thr?Leu?Phe?Lys?Asp?Val

50 55 60

Asp?Val?Val?Tyr?Tyr?Leu?Val?His?Ser?Met?Gly?Gly?Lys?Asn?Val?Asp

65 70 75 80

Phe?Glu?Glu?Gln?Glu?Gln?Arg?Thr?Ala?Glu?Asn?Val?Ile?Gln?Ala?Ala

85 90 95

Asp?Gln?Ala?Gly?Ile?Lys?Gln?Ile?Val?Tyr?Leu?Ser?Gly?Leu?His?Pro

100 105 110

Arg?Asn?Arg?Lys?Ile?Glu?Glu?Leu?Ser?Lys?His?Met?Arg?Ser?Arg?Glu

115 120 125

Lys?Val?Ala?Gln?Ile?Leu?Leu?Ala?Gly?Gln?Thr?Pro?Ala?Leu?Ile?Leu

130 135 140

Arg?Ala?Ala?Thr?Ile?Ile?Gly?Ser?Gly?Ser?Ala?Ser?Phe?Glu?Ile?Ile

145 150 155 160

Arg?His?Leu?Thr?Glu?Arg?Leu?Pro?Arg?Met?Ile?Ala?Pro?Gln?Trp?Ile

165 170 175

Thr?Asn?Gln?Ile?Glu?Pro?Leu?Ala?Ile?Arg?Asp?Val?Leu?His?Tyr?Leu

180 185 190

Ile?Ser?Ala?Ala?Asp?Leu?Lys?Asp?Pro?Val?Asn?Arg?Ser?Cys?Asp?Ile

195 200 205

Gly?Cys?Gly?Lys?Ser?Tyr?Glu?Phe?Ala?Asp?Leu?Leu?Arg?Ile?Tyr?Ala

210 215 220

Asp?Val?Arg?Gly?Leu?Lys?Arg?His?Val?Asn?Ser?Val?Pro?Leu?Asn?Leu

225 230 235 240

Pro?Met?Asp?Lys?Leu?Ser?Gly?Leu?Trp?Ile?Ser?Leu?Val?Thr?Pro?Val

245 250 255

Pro?Phe?Gln?Leu?Ser?Phe?Pro?Leu?Ala?Gln?Ser?Met?Ala?Glu?Asp?Ala

260 265 270

Val?Thr?Glu?Glu?His?Ser?Ile?Lys?Asp?Ile?Ile?Ser?Asp?Pro?Pro?Asp

275 280 285

Gly?Phe?Ile?Glu?Tyr?Arg?Glu?Ala?Val?Glu?Leu?Ala?Leu?Ala?Ala?Glu

290 295 300

Phe?Asp?Arg?Gly?Val?Pro?Thr?Ser?Trp?Asp?Arg?Ser?Trp?Thr?Val?Gln

305 310 315 320

Gln?Pro?Trp?Ala?Gly?Gln?Pro?Thr?Asp?Pro?Glu?Trp?Ala?Gly?Lys?Ala

325 330 335

Val?Tyr?Glu?Asp?Val?Arg?Thr?Glu?Asp?Thr?Asp?Leu?Arg?Ala?Ala?Gln

340 345 350

Val?Trp?Pro?Ile?Ile?Glu?Gly?Leu?Gly?Gly?Val?Asn?Gly?Trp?Tyr?Ser

355 360 365

Ala?Pro?Leu?Leu?Trp?Arg?Leu?Arg?Gly?Ile?Ala?Asp?Arg?Leu?Ile?Gly

370 375 380

Gly?Pro?Gly?Leu?Gly?Gly?Arg?Arg?Asp?Pro?Arg?His?Leu?Lys?Leu?Gly

385 390 395 400

Asp?Arg?Ile?Asp?Trp?Trp?Arg?Val?Thr?Glu?Ile?Asp?Pro?Pro?His?Arg

405 410 415

Leu?Val?Leu?Thr?Ala?Glu?Met?Lys?Val?Asp?Gly?Gly?Ala?Trp?Leu?Ile

420 425 430

Leu?Glu?Val?Ala?Asp?Lys?Glu?Asn?Gly?Gly?Cys?Thr?Tyr?Thr?Gln?Arg

435 440 445

Ala?Ile?Phe?Glu?Pro?Lys?Gly?Leu?Pro?Gly?Tyr?Leu?Tyr?Trp?Trp?Val

450 455 460

Val?Ser?Pro?Phe?His?Ala?Ile?Ile?Phe?Pro?Tyr?Met?Arg?Ser?Asn?Ile

465 470 475 480

Leu?Lys?Ala?Ala?Arg?Lys?Leu?Thr

485

<210>701

<211>612

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(589)

<223>RXA01534

<400>701

attgctctca?tcggttcgat?atagactgaa?ttgtctaggt?taatatccaa?tatggaagaa?60

aaactagaca?gttaagtaga?ctgaatggcc?tactaggtgc?atg?act?tca?gca?atc 115

Met?Thr?Ser?Ala?Ile

1 5

acc?acc?gca?act?gat?ctt?cgc?tcc?gta?ctg?cga?aac?gta?cca?acc?cca 163

Thr?Thr?Ala?Thr?Asp?Leu?Arg?Ser?Val?Leu?Arg?Asn?Val?Pro?Thr?Pro

10 15 20

att?agc?ttc?att?gca?acc?cac?acc?gat?cag?cct?ctg?ggc?atg?atc?gtt 211

Ile?Ser?Phe?Ile?Ala?Thr?His?Thr?Asp?Gln?Pro?Leu?Gly?Met?lle?Val

25 30 35

ggt?tca?ttc?gtc?agc?att?agc?gcc?gaa?cca?cca?ttg?gta?ggc?atc?ttc 259

Gly?Ser?Phe?Val?Ser?Ile?Ser?Ala?Glu?Pro?Pro?Leu?Val?Gly?Ile?Phe

40 45 50

ttg?cag?aag?agc?tct?tct?tca?tgg?cca?gct?atc?gag?cag?gca?tta?gtt 307

Leu?Gln?Lys?Ser?Ser?Ser?Ser?Trp?Pro?Ala?Ile?Glu?Gln?Ala?Leu?Val

55 60 65

acc?ggc?caa?gag?cta?ggc?att?tct?atc?ctc?ggc?ggg?gca?cac?gca?gac 355

Thr?Gly?Gln?Glu?Leu?Gly?Ile?Ser?Ile?Leu?Gly?Gly?Ala?His?Ala?Asp

70 75 80 85

cat?gtg?cgt?aag?ctt?tct?ggc?cca?tcc?gac?cag?cgc?ttt?gaa?aac?ctt 403

His?Val?Arg?Lys?Leu?Ser?Gly?Pro?Ser?Asp?Gln?Arg?Phe?Glu?Asn?Leu

90 95 100

ggg?tgg?gca?tcc?acc?gaa?aac?ggt?gcg?att?cac?ctt?gaa?ggc?gct?gat 451

Gly?Trp?Ala?Ser?Thr?Glu?Asn?Gly?Ala?Ile?His?Leu?Glu?Gly?Ala?Asp

105 110 115

gca?caa?cta?acc?acg?aaa?ctt?cat?gat?ctc?cag?gaa?atc?ggc?gat?cac 499

Ala?Gln?Leu?Thr?Thr?Lys?Leu?His?Asp?Leu?Gln?Glu?Ile?Gly?Asp?His

120 125 130

ttc?ttt?gca?gtt?cta?gaa?gtt?att?gac?gct?tcc?gct?gac?caa?gac?ttc 547

Phe?Phe?Ala?Val?Leu?Glu?Val?Ile?Asp?Ala?Ser?Ala?Asp?Gln?Asp?Phe

135 140 145

agc?tca?gcg?ctg?gtg?tac?cac?cgc?tca?cag?gtg?tcc?tcg?ctg 589

Ser?Ser?Ala?Leu?Val?Tyr?His?Arg?Ser?Gln?Val?Ser?Ser?Leu

150 155 160

taggacacta?aattttaaga?ggg 612

<210>702

<21l>163

<212>PRT

＜213〉Corynebacterium glutamicum

<400>702

Met?Thr?Ser?Ala?Ile?Thr?Thr?Ala?Thr?Asp?Leu?Arg?Ser?Val?Leu?Arg

1 5 10 15

Asn?Val?Pro?Thr?Pro?Ile?Ser?Phe?Ile?Ala?Thr?His?Thr?Asp?Gln?Pro

20 25 30

Leu?GIy?Met?Ile?Val?Gly?Ser?Phe?Val?Ser?Ile?Ser?Ala?Glu?Pro?Pro

35 40 45

Leu?Val?Gly?Ile?Phe?Leu?Gln?Lys?Ser?Ser?Ser?Ser?Trp?Pro?Ala?Ile

50 55 60

Glu?Gln?Ala?Leu?Val?Thr?Gly?Gln?Glu?Leu?Gly?Ile?Ser?Ile?Leu?Gly

65 70 75 80

Gly?Ala?His?Ala?Asp?His?Val?Arg?Lys?Leu?Ser?Gly?Pro?Ser?Asp?Gln

85 90 95

Arg?Phe?Glu?Asn?Leu?Gly?Trp?Ala?Ser?Thr?Glu?Asn?Gly?Ala?Ile?His

100 105 110

Leu?Glu?Gly?Ala?Asp?Ala?Gln?Leu?Thr?Thr?Lys?Leu?His?Asp?Leu?Gln

115 120 125

Glu?Ile?Gly?Asp?His?Phe?Phe?Ala?Val?Leu?Glu?Val?Ile?Asp?Ala?Ser

130 135 140

Ala?Asp?Gln?Asp?Phe?Ser?Ser?Ala?Leu?Val?Tyr?His?Arg?Ser?Gln?Val

145 150 155 160

Ser?Ser?Leu

<210>703

<211>1134

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1111)

<223>RXA00288

<400>703

ggcgtgctaa?aaaagcacgt?caaatacaga?atcggcagat?tacatcgctg?agcagagaaa?60

acacgggcat?gaaacgtacc?caagggctaa?catcgggggc?atg?agc?gcg?caa?atg 115

Met?Ser?Ala?Gln?Met

1 5

gat?acc?cct?gat?ccc?act?atg?tct?gct?gtt?gca?atg?tta?gat?tcc?atc 163

Asp?Thr?Pro?Asp?Pro?Thr?Met?Ser?Ala?Val?Ala?Met?Leu?Asp?Ser?Ile

10 15 20

cct?tct?gat?caa?cca?gat?ttc?ctg?atc?gat?gta?gaa?gta?gat?cga?cca 211

Pro?Ser?Asp?Gln?Pro?Asp?Phe?Leu?Ile?Asp?Val?Glu?Val?Asp?Arg?Pro

25 30 35

act?ccc?gga?cca?cat?gat?ctg?cta?gtc?cac?att?gag?gcg?gtc?tca?att 259

Thr?Pro?Gly?Pro?His?Asp?Leu?Leu?Val?His?Ile?Glu?Ala?Val?Ser?Ile

40 45 50

aac?cct?gtt?gat?acc?aag?gta?cgc?atg?cgg?gcc?ggg?aag?caa?aag?cat 307

Asn?Pro?Val?Asp?Thr?Lys?Val?Arg?Met?Arg?Ala?Gly?Lys?Gln?Lys?His

55 60 65

cct?aaa?att?tta?ggt?ttt?gat?gct?gca?ggt?gag?gtg?gtg?gct?gtt?gga 355

Pro?Lys?Ile?Leu?Gly?Phe?Asp?Ala?Ala?Gly?Glu?Val?Val?Ala?Val?Gly

70 75 80 85

tcg?cag?gtc?acg?ctc?ttc?aat?gtt?ggt?gac?aaa?gtg?ttc?tac?gca?gga 403

Ser?Gln?Val?Thr?Leu?Phe?Asn?Val?Gly?Asp?Lys?Val?Phe?Tyr?Ala?Gly

90 95 100

tcc?aat?cag?cgt?cca?gga?agt?aac?gca?gag?tac?cag?gtg?gtg?gat?gaa 451

Ser?Asn?Gln?Arg?Pro?Gly?Ser?Asn?Ala?Glu?Tyr?Gln?Val?Val?Asp?Glu

105 110 115

cgg?ctg?gtg?ggt?cac?gca?cca?caa?agc?ttg?ggg?gca?cac?gac?gcc?gct 499

Arg?Leu?Val?Gly?His?Ala?Pro?Gln?Ser?Leu?Gly?Ala?His?Asp?Ala?Ala

120 125 130

gct?ctc?cca?ctt?gtc?gcg?ctc?act?gca?tgg?gag?tca?ctt?ttt?gac?cga 547

Ala?Leu?Pro?Leu?Val?Ala?Leu?Thr?Ala?Trp?Glu?Ser?Leu?Phe?Asp?Arg

135 140 145

ttg?gga?gta?act?cag?tca?act?act?gga?aca?ctg?ttg?gtc?ttg?ggc?ggt 595

Leu?Gly?Val?Thr?Gln?Ser?Thr?Thr?Gly?Thr?Leu?Leu?Val?Leu?Gly?Gly

150 155 160 165

tca?gga?ggt?gtg?cct?tca?gct?ctt?att?caa?ctt?gct?cga?gct?ctc?act 643

Ser?Gly?Gly?Val?Pro?Ser?Ala?Leu?Ile?Gln?Leu?Ala?Arg?Ala?Leu?Thr

170 175 180

ggt?ctg?aaa?gta?gtg?gca?aca?gct?tct?cgc?cct?gaa?tca?caa?gaa?tgg 691

Gly?Leu?Lys?Val?Val?Ala?Thr?Ala?Ser?Arg?Pro?Glu?Ser?Gln?Glu?Trp

185 190 195

gtg?aca?aag?ctc?ggt?gct?cat?gag?gtg?att?gat?cac?tcc?aag?gat?ttg 739

Val?Thr?Lys?Leu?Gly?Ala?His?Glu?Val?Ile?Asp?His?Ser?Lys?Asp?Leu

200 205 210

agt?gag?caa?atc?tcc?gac?gtg?gat?ttt?gtt?ttc?agc?tcg?tgg?act?act 787

Ser?Glu?Gln?Ile?Ser?Asp?Val?Asp?Phe?Val?Phe?Ser?Ser?Trp?Thr?Thr

215 220 225

ggg?cgt?gaa?gta?gag?ctc?gcc?acg?ttg?atg?aaa?ccc?cag?tcc?cac?cta 835

Gly?Arg?Glu?Val?Glu?Leu?Ala?Thr?Leu?Met?Lys?Pro?Gln?Ser?His?Leu

230 235 240 245

gtg?ctc?atc?gat?gat?cca?gtg?gat?ccc?aat?ttg?ggc?gct?ttt?aag?caa 883

Val?Leu?Ile?Asp?Asp?Pro?Val?Asp?Pro?Asn?Leu?Gly?Ala?Phe?Lys?Gln

250 255 260

aaa?gcg?atc?gct?ttg?cac?tgg?gag?ttc?atg?ttt?acc?cgc?gct?atg?ttc 931

Lys?Ala?Ile?Ala?Leu?His?Trp?Glu?Phe?Met?Phe?Thr?Arg?Ala?Met?Phe

265 270 275

aac?act?cct?gat?atg?ggt?gaa?caa?ggg?aaa?att?ctg?aat?aag?atc?gcc 979

Asn?Thr?Pro?Asp?Met?Gly?Glu?Gln?Gly?Lys?Ile?Leu?Asn?Lys?Ile?Ala

280 285 290

gac?atg?gtt?gat?cgg?ggt?cag?ttt?gag?tcc?gtg?aca?gca?acg?gtg?ctg 1027

Asp?Met?Val?Asp?Arg?Gly?Gln?Phe?Glu?Ser?Val?Thr?Ala?Thr?Val?Leu

295 300 305

gat?ggg?ctc?aac?gct?gca?aac?atc?atg?gag?ggg?cac?cgg?ctc?gtt?gag 1075

Asp?Gly?Leu?Asn?Ala?Ala?Asn?Ile?Met?Glu?Gly?His?Arg?Leu?Val?Glu

310 315 320 325

cag?ggt?aaa?acc?tca?gga?aaa?att?gtt?gtg?agg?gta?taaagaggac 1121

Gln?Gly?Lys?Thr?Ser?Gly?Lys?Ile?Val?Val?Arg?Val

330 335

ttgaaaaatg?cac 1134

<210>704

<211>337

<212>PRT

＜213〉Corynebacterium glutamicum

<400>704

Met?Ser?Ala?Gln?Met?Asp?Thr?Pro?Asp?Pro?Thr?Met?Ser?Ala?Val?Ala

1 5 10 15

Met?Leu?Asp?Ser?Ile?Pro?Ser?Asp?Gln?Pro?Asp?Phe?Leu?Ile?Asp?Val

20 25 30

Glu?Val?Asp?Arg?Pro?Thr?Pro?Gly?Pro?His?Asp?Leu?Leu?Val?His?Ile

35 40 45

Glu?Ala?Val?Ser?Ile?Asn?Pro?Val?Asp?Thr?Lys?Val?Arg?Met?Arg?Ala

50 55 60

Gly?Lys?Gln?Lys?His?Pro?Lys?Ile?Leu?Gly?Phe?Asp?Ala?Ala?Gly?Glu

65 70 75 80

Val?Val?Ala?Val?Gly?Ser?Gln?Val?Thr?Leu?Phe?Asn?Val?Gly?Asp?Lys

85 90 95

Val?Phe?Tyr?Ala?Gly?Ser?Asn?Gln?Arg?Pro?Gly?Ser?Asn?Ala?Glu?Tyr

100 105 110

Gln?Val?Val?Asp?Glu?Arg?Leu?Val?Gly?His?Ala?Pro?Gln?Ser?Leu?Gly

115 120 125

Ala?His?Asp?Ala?Ala?Ala?Leu?Pro?Leu?Val?Ala?Leu?Thr?Ala?Trp?Glu

130 135 140

Ser?Leu?Phe?Asp?Arg?Leu?Gly?Val?Thr?Gln?Ser?Thr?Thr?Gly?Thr?Leu

145 150 155 160

Leu?Val?Leu?Gly?Gly?Ser?Gly?Gly?Val?Pro?Ser?Ala?Leu?Ile?Gln?Leu

165 170 175

Ala?Arg?Ala?Leu?Thr?Gly?Leu?Lys?Val?Val?Ala?Thr?Ala?Ser?Arg?Pro

180 185 190

Glu?Ser?Gln?Glu?Trp?Val?Thr?Lys?Leu?Gly?Ala?His?Glu?Val?Ile?Asp

195 200 205

His?Ser?Lys?Asp?Leu?Ser?Glu?Gln?Ile?Ser?Asp?Val?Asp?Phe?Val?Phe

210 215 220

Ser?Ser?Trp?Thr?Thr?Gly?Arg?Glu?Val?Glu?Leu?Ala?Thr?Leu?Met?Lys

225 230 235 240

Pro?Gln?Ser?His?Leu?Val?Leu?Ile?Asp?Asp?Pro?Val?Asp?Pro?Asn?Leu

245 250 255

Gly?Ala?Phe?Lys?Gln?Lys?Ala?Ile?Ala?Leu?His?Trp?Glu?Phe?Met?Phe

260 265 270

Thr?Arg?Ala?Met?Phe?Asn?Thr?Pro?Asp?Met?Gly?Glu?Gln?Gly?Lys?Ile

275 280 285

Leu?Asn?Lys?Ile?Ala?Asp?Met?Val?Asp?Arg?Gly?Gln?Phe?Glu?Ser?Val

290 295 300

Thr?Ala?Thr?Val?Leu?Asp?Gly?Leu?Asn?Ala?Ala?Asn?Ile?Met?Glu?Gly

305 310 315 320

His?Arg?Leu?Val?Glu?Gln?Gly?Lys?Thr?Ser?Gly?Lys?Ile?Val?Val?Arg

325 330 335

Val

<210>705

<211>1089

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1066)

<223>RXA02741

<400>705

actggtcacc?tggtttggtc?tgcactctga?ctcccctcaa?aagggcacaa?tttggtcaat?60

ttcccaacct?tgtctttcag?tcatggttag?tgtgggaacc?atg?aag?gca?atc?tta 115

Met?Lys?Ala?Ile?Leu

1 5

gtt?tcc?cgc?acc?ggc?gga?cca?gag?gtg?ttg?gag?ttc?acc?gac?act?gac 163

Val?Ser?Arg?Thr?Gly?Gly?Pro?Glu?Val?Leu?Glu?Phe?Thr?Asp?Thr?Asp

10 15 20

gcc?cca?aag?ccc?act?gat?gat?cag?gtt?tta?gtt?gaa?gtt?gat?atg?gct 211

Ala?Pro?Lys?Pro?Thr?Asp?Asp?Gln?Val?Leu?Val?Glu?Val?Asp?Met?Ala

25 30 35

ggc?gtc?aac?ttt?att?gat?act?tac?tat?cgc?cag?ggt?gaa?tat?cac?gct 259

Gly?Val?Asn?Phe?Ile?Asp?Thr?Tyr?Tyr?Arg?Gln?Gly?Glu?Tyr?His?Ala

40 45 50

cgc?ctg?ccg?ttt?atc?cca?ggt?ttt?gaa?ggc?act?ggt?cgg?gtg?ttg?gag 307

Arg?Leu?Pro?Phe?Ile?Pro?Gly?Phe?Glu?Gly?Thr?Gly?Arg?Val?Leu?Glu

55 60 65

gat?ccg?cag?ggg?ttg?att?gcg?gcg?ggt?acc?aag?gtg?gcg?tgg?tgt?gat 355

Asp?Pro?Gln?Gly?Leu?Ile?Ala?Ala?Gly?Thr?Lys?Val?Ala?Trp?Cys?Asp

70 75 80 85

gcc?atg?ggt?tcg?tat?gct?cag?cag?gtg?tgt?gtg?ccg?cgg?gat?cgc?ttg 403

Ala?Met?Gly?Ser?Tyr?Ala?Gln?Gln?Val?Cys?Val?Pro?Arg?Asp?Arg?Leu

90 95 100

gtg?gcg?gtt?ccc?gag?ggc?gtg?agt?tcg?gaa?gtg?gct?gcg?tcg?atg?ttg 451

Val?Ala?Val?Pro?Glu?Gly?Val?Ser?Ser?Glu?Val?Ala?Ala?Ser?Met?Leu

105 110 115

atg?cag?gga?atc?act?gcg?cat?tat?cta?acc?aat?ggt?gtg?tat?gag?ctt 499

Met?Gln?Gly?Ile?Thr?Ala?His?Tyr?Leu?Thr?Asn?Gly?Val?Tyr?Glu?Leu

120 125 130

gaa?gag?ggc?gat?tct?tgc?etc?atc?act?gct?ggc?gcg?ggt?ggt?gtt?gga 547

Glu?Glu?Gly?Asp?Ser?Cys?Leu?Ile?Thr?Ala?Gly?Ala?Gly?Gly?Val?Gly

135 140 145

ttg?ttg?gct?acg?cag?atg?gcg?gcg?gcc?aag?gga?gtg?cgc?gtg?tac?agc 595

Leu?Leu?Ala?Thr?Gln?Met?Ala?Ala?Ala?Lys?Gly?Val?Arg?Val?Tyr?Ser

150 155 160 165

gtg?gtg?tcc?acg?gat?gaa?aaa?gct?gag?ctt?gct?ttg?gat?gcc?ggt?gct 643

Val?Val?Ser?Thr?Asp?Glu?Lys?Ala?Glu?Leu?Ala?Leu?Asp?Ala?Gly?Ala

170 175 180

tat?gag?gtg?ttt?cgt?tat?tcc?gat?aat?ttg?gcg?gag?cag?gtt?cgt?cgg 691

Tyr?Glu?Val?Phe?Arg?Tyr?Ser?Asp?Asn?Leu?Ala?Glu?Gln?Val?Arg?Arg

185 190 195

cac?aac?ggg?ggt?cgc?gga?gtt?gat?gtg?gtg?tat?gac?ggt?gtc?ggc?cag 739

His?Asn?Gly?Gly?Arg?Gly?Val?Asp?Val?Val?Tyr?Asp?Gly?Val?Gly?Gln

200 205 210

tcc?acg?ttc?aat?gag?tcc?tta?gag?gct?gtt?cgt?ccg?cgc?ggc?act?gtg 787

Ser?Thr?Phe?Asn?Glu?Ser?Leu?Glu?Ala?Val?Arg?Pro?Arg?Gly?Thr?Val

215 220 225

tgt?ttg?ttt?ggt?gcg?gcg?tcg?ggt?cct?gtg?gag?cct?ttt?gat?ccg?cag 835

Cys?Leu?Phe?Gly?Ala?Ala?Ser?Gly?Pro?Val?Glu?Pro?Phe?Asp?Pro?Gln

230 235 240 245

ctg?ttg?aac?act?cac?ggt?tcg?atc?ttc?ttg?acc?cgc?cca?agc?att?ggc 883

Leu?Leu?Asn?Thr?His?Gly?Ser?Ile?Phe?Leu?Thr?Arg?Pro?Ser?Ile?Gly

250 255 260

gcg?tgg?acg?tct?gag?gag?ggc?gaa?ttt?gcc?aag?cgt?gca?cag?gcg?gtc 931

Ala?Trp?Thr?Ser?Glu?Glu?Gly?Glu?Phe?Ala?Lys?Arg?Ala?Gln?Ala?Val

265 270 275

acg?cag?gcc?atc?gtc?gaa?ggc?acc?ttg?cgg?gtt?cgc?gtt?act?ggc?aca 979

Thr?Gln?Ala?Ile?Val?Glu?Gly?Thr?Leu?Arg?Val?Arg?Val?Thr?Gly?Thr

280 285 290

tat?tcg?ctt?gcc?gac?gcc?tac?atc?gcc?cac?cgc?gac?ctt?cag?gcg?cgt 1027

Tyr?Ser?Leu?Ala?Asp?Ala?Tyr?Ile?Ala?His?Arg?Asp?Leu?Gln?Ala?Arg

295 300 305

agc?acg?agc?ggt?tct?ttg?gtc?ttg?gaa?atc?ccg?aag?gac?taaacacgca 1076

Ser?Thr?Ser?Gly?Ser?Leu?Val?Leu?Glu?Ile?Pro?Lys?Asp

310 315 320

taaaaagatc?ctg 1089

<210>706

<211>322

<212>PRT

＜213〉Corynebacterium glutamicum

<400>706

Met?Lys?Ala?Ile?Leu?Val?Ser?Arg?Thr?Gly?Gly?Pro?Glu?Val?Leu?Glu

1 5 10 15

Phe?Thr?Asp?Thr?Asp?Ala?Pro?Lys?Pro?Thr?Asp?Asp?Gln?Val?Leu?Val

20 25 30

Glu?Val?Asp?Met?Ala?Gly?Val?Asn?Phe?Ile?Asp?Thr?Tyr?Tyr?Arg?Gln

35 40 45

Gly?Glu?Tyr?His?Ala?Arg?Leu?Pro?Phe?Ile?Pro?Gly?Phe?Glu?Gly?Thr

50 55 60

Gly?Arg?Val?Leu?Glu?Asp?Pro?Gln?Gly?Leu?Ile?Ala?Ala?Gly?Thr?Lys

65 70 75 80

Val?Ala?Trp?Cys?Asp?Ala?Met?Gly?Ser?Tyr?Ala?Gln?Gln?Val?Cys?Val

85 90 95

Pro?Arg?Asp?Arg?Leu?Val?Ala?Val?Pro?Glu?Gly?Val?Ser?Ser?Glu?Val

100 105 110

Ala?Ala?Ser?Met?Leu?Met?Gln?Gly?Ile?Thr?Ala?His?Tyr?Leu?Thr?Asn

115 120 125

Gly?Val?Tyr?Glu?Leu?Glu?Glu?Gly?Asp?Ser?Cys?Leu?Ile?Thr?Ala?Gly

130 135 140

Ala?Gly?Gly?Val?Gly?Leu?Leu?Ala?Thr?Gln?Met?Ala?Ala?Ala?Lys?Gly

145 150 155 160

Val?Arg?Val?Tyr?Ser?Val?Val?Ser?Thr?Asp?Glu?Lys?Ala?Glu?Leu?Ala

165 170 175

Leu?Asp?Ala?Gly?Ala?Tyr?Glu?Val?Phe?Arg?Tyr?Ser?Asp?Asn?Leu?Ala

180 185 190

Glu?Gln?Val?Arg?Arg?His?Asn?Gly?Gly?Arg?Gly?Val?Asp?Val?Val?Tyr

195 200 205

Asp?Gly?Val?Gly?Gln?Ser?Thr?Phe?Asn?Glu?Ser?Leu?Glu?Ala?Val?Arg

210 215 220

Pro?Arg?Gly?Thr?Val?Cys?Leu?Phe?Gly?Ala?Ala?Ser?Gly?Pro?Val?Glu

225 230 235 240

Pro?Phe?Asp?Pro?Gln?Leu?Leu?Asn?Thr?His?Gly?Ser?Ile?Phe?Leu?Thr

245 250 255

Arg?Pro?Ser?Ile?Gly?Ala?Trp?Thr?Ser?Glu?Glu?Gly?Glu?Phe?Ala?Lys

260 265 270

Arg?Ala?Gln?Ala?Val?Thr?Gln?Ala?Ile?Val?Glu?Gly?Thr?Leu?Arg?Val

275 280 285

Arg?Val?Thr?Gly?Thr?Tyr?Ser?Leu?Ala?Asp?Ala?Tyr?Ile?Ala?His?Arg

290 295 300

Asp?Leu?Gln?Ala?Arg?Ser?Thr?Ser?Gly?Ser?Leu?Val?Leu?Glu?Ile?Pro

305 310 315 320

Lys?Asp

<210>707

<211>990

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(967)

<223>RXN02560

<400>707

ttggggcaag?ccagctaacg?catttcttgt?ggaaaccgca?gacattgagg?ccgcccacgc?60

ggaacttcta?agagcagtgg?aatgaaataa?tccggtgctg?atg?cag?ggc?aac?tcg 115

Met?Gln?Gly?Asn?Ser

1 5

ctt?aat?ctg?gca?gac?aac?agc?gag?aga?aag?aag?ccc?atg?ccg?tca?cca 163

Leu?Asn?Leu?Ala?Asp?Asn?Ser?Glu?Arg?Lys?Lys?Pro?Met?Pro?Ser?Pro

10 15 20

gga?gaa?ctt?tta?gcc?gcc?cgc?tac?gga?caa?cct?gca?acc?tgg?acg?cca 211

Gly?Glu?Leu?Leu?Ala?Ala?Arg?Tyr?Gly?Gln?Pro?Ala?Thr?Trp?Thr?Pro

25 30 35

ccg?cag?tgg?aat?gag?acg?ctt?gat?gtc?att?cac?cag?cat?cga?tca?gtt 259

Pro?Gln?Trp?Asn?Glu?Thr?Leu?Asp?Val?Ile?His?Gln?His?Arg?Ser?Val

40 45 50

cgc?agg?tgg?ttg?gat?aaa?ccg?gtt?gat?gat?gac?acc?atc?cgc?acc?att 307

Arg?Arg?Trp?Leu?Asp?Lys?Pro?Val?Asp?Asp?Asp?Thr?Ile?Arg?Thr?Ile

55 60 65

att?tcc?gcc?gca?caa?tcg?gct?gga?acc?tct?tcc?aat?aag?cag?gtc?att 355

Ile?Ser?Ala?Ala?Gln?Ser?Ala?Gly?Thr?Ser?Ser?Asn?Lys?Gln?Val?Ile

70 75 80 85

tct?gtc?atc?gtg?gtt?aaa?gat?cct?gag?ctg?agg?aaa?ggc?ctc?gcg?ggg 403

Ser?Val?Ile?Val?Val?Lys?Asp?Pro?Glu?Leu?Arg?Lys?Gly?Leu?Ala?Gly

90 95 100

atc?act?cgc?cag?atg?ttt?ccg?cac?ctt?gag?cag?gtt?ccc?gcg?gtg?ctg 451

Ile?Thr?Arg?Gln?Met?Phe?Pro?His?Leu?Glu?Gln?Val?Pro?Ala?Val?Leu

105 110 115

att?tgg?ttg?att?gat?tat?tcc?cga?atc?agt?gcg?gtg?gca?gcc?aga?gaa 499

Ile?Trp?Leu?Ile?Asp?Tyr?Ser?Arg?Ile?Ser?Ala?Val?Ala?Ala?Arg?Glu

120 125 130

gat?ctc?cca?aca?ggg?gct?ctt?gat?tat?ctc?gat?gag?gcc?gcg?tgg?ggg 547

Asp?Leu?Pro?Thr?Gly?Ala?Leu?Asp?Tyr?Leu?Asp?Glu?Ala?Ala?Trp?Gly

135 140 145

ttc?ctc?gac?gcc?gga?atc?gca?gct?caa?aac?gct?gca?att?gct?gcg?gag 595

Phe?Leu?Asp?Ala?Gly?Ile?Ala?Ala?Gln?Asn?Ala?Ala?Ile?Ala?Ala?Glu

150 155 160 165

tca?ctt?gga?ttg?gga?acg?ctc?tat?ttg?ggt?tcg?gtg?cgc?aac?gat?gcg 643

Ser?Leu?Gly?Leu?Gly?Thr?Leu?Tyr?Leu?Gly?Ser?Val?Arg?Asn?Asp?Ala

170 175 180

gaa?gcc?gtg?cac?aaa?ttg?ctt?ggc?ctt?cca?cct?gag?atc?gtg?cct?gtc 691

Glu?Ala?Val?His?Lys?Leu?Leu?Gly?Leu?Pro?Pro?Glu?Ile?Val?Pro?Val

185 190 195

gtg?ggc?ttg?gaa?atg?ggg?cat?gcg?gat?ccg?cct?gaa?cct?gcc?gga?att 739

Val?Gly?Leu?Glu?Met?Gly?His?Ala?Asp?Pro?Pro?Glu?Pro?Ala?Gly?Ile

200 205 210

aaa?cct?ccc?ctg?cca?caa?gaa?gcc?att?gtt?cac?tgg?gat?acc?tac?acc 787

Lys?Pro?Pro?Leu?Pro?Gln?Glu?Ala?Ile?Val?His?Trp?Asp?Thr?Tyr?Thr

215 220 225

gag?aaa?aac?ctc?gaa?ctt?atc?gat?tcc?tac?gac?cgc?gcc?ctc?gac?act 835

Glu?Lys?Asn?Leu?Glu?Leu?Ile?Asp?Ser?Tyr?Asp?Arg?Ala?Leu?Asp?Thr

230 235 240 245

tac?tat?tct?cgc?tac?ggc?cag?cac?cag?ctc?tgg?tcg?aag?cag?acg?gcg 883

Tyr?Tyr?Ser?Arg?Tyr?Gly?Gln?His?Gln?Leu?Trp?Ser?Lys?Gln?Thr?Ala

250 255 260

cat?agg?gcg?gcg?tcg?aaa?agc?ttt?tca?aaa?acc?aac?agg?cag?ttc?ctt 931

His?Arg?Ala?Ala?Ser?Lys?Ser?Phe?Ser?Lys?Thr?Asn?Arg?Gln?Phe?Leu

265 270 275

agg?ggc?gtg?ttt?gag?cgc?gcc?ggg?ttt?ggg?ctg?aga?taaaagcatg 977

Arg?Gly?Val?Phe?Glu?Arg?Ala?Gly?Phe?Gly?Leu?Arg

280 285

attatggacg?cct 990

<210>708

<211>289

<212>PRT

＜213〉Corynebacterium glutamicum

<400>708

Met?Gln?Gly?Asn?Ser?Leu?Asn?Leu?Ala?Asp?Asn?Ser?Glu?Arg?Lys?Lys

1 5 10 15

Pro?Met?Pro?Ser?Pro?Gly?Glu?Leu?Leu?Ala?Ala?Arg?Tyr?Gly?Gln?Pro

20 25 30

Ala?Thr?Trp?Thr?Pro?Pro?Gln?Trp?Asn?Glu?Thr?Leu?Asp?Val?Ile?His

35 40 45

Gln?His?Arg?Ser?Val?Arg?Arg?Trp?Leu?Asp?Lys?Pro?Val?Asp?Asp?Asp

50 55 60

Thr?Ile?Arg?Thr?Ile?Ile?Ser?Ala?Ala?Gln?Ser?Ala?Gly?Thr?Ser?Ser

65 70 75 80

Asn?Lys?Gln?Val?Ile?Ser?Val?Ile?Val?Val?Lys?Asp?Pro?Glu?Leu?Arg

85 90 95

Lys?Gly?Leu?Ala?Gly?Ile?Thr?Arg?Gln?Met?Phe?Pro?His?Leu?Glu?Gln

100 105 110

Val?Pro?Ala?Val?Leu?Ile?Trp?Leu?Ile?Asp?Tyr?Ser?Arg?Ile?Ser?Ala

115 120 125

Val?Ala?Ala?Arg?Glu?Asp?Leu?Pro?Thr?Gly?Ala?Leu?Asp?Tyr?Leu?Asp

130 135 140

Glu?Ala?Ala?Trp?Gly?Phe?Leu?Asp?Ala?Gly?Ile?Ala?Ala?Gln?Asn?Ala

145 150 155 160

Ala?Ile?Ala?Ala?Glu?Ser?Leu?Gly?Leu?Gly?Thr?Leu?Tyr?Leu?Gly?Ser

165 170 175

Val?Arg?Asn?Asp?Ala?Glu?Ala?Val?His?Lys?Leu?Leu?Gly?Leu?Pro?Pro

180 185 190

Glu?Ile?Val?Pro?Val?Val?Gly?Leu?Glu?Met?Gly?His?Ala?Asp?Pro?Pro

195 200 205

Glu?Pro?Ala?Gly?Ile?Lys?Pro?Pro?Leu?Pro?Gln?Glu?Ala?Ile?Val?His

210 215 220

Trp?Asp?Thr?Tyr?Thr?Glu?Lys?Asn?Leu?Glu?Leu?Ile?Asp?Ser?Tyr?Asp

225 230 235 240

Arg?Ala?Leu?Asp?Thr?Tyr?Tyr?Ser?Arg?Tyr?Gly?Gln?His?Gln?Leu?Trp

245 250 255

Ser?Lys?Gln?Thr?Ala?His?Arg?Ala?Ala?Ser?Lys?Ser?Phe?Ser?Lys?Thr

260 265 270

Asn?Arg?Gln?Phe?Leu?Arg?Gly?Val?Phe?Glu?Arg?Ala?Gly?Phe?Gly?Leu

275 280 285

Arg

<210>709

<211>922

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(922)

<223>FRXA02560

<400>709

ttggggcaag?ccagctaacg?catttcttgt?ggaaaccgca?gacattgagg?ccgcccacgc?60

ggaacttcta?agagcagtgg?aatgaaataa?tccggtgctg?atg?cag?ggc?aac?tcg 115

Met?Gln?Gly?Asn?Ser

1 5

ctt?aat?ctg?gca?gac?aac?agc?gag?aga?aag?aag?ccc?atg?ccg?tca?cca 163

Leu?Asn?Leu?Ala?Asp?Asn?Ser?Glu?Arg?Lys?Lys?Pro?Met?Pro?Ser?Pro

10 15 20

gga?gaa?ctt?tta?gcc?gcc?cgc?tac?gga?caa?cct?gca?acc?tgg?acg?cca 211

Gly?Glu?Leu?Leu?Ala?Ala?Arg?Tyr?Gly?Gln?Pro?Ala?Thr?Trp?Thr?Pro

25 30 35

ccg?cag?tgg?aat?gag?acg?ctt?gat?gtc?att?cac?cag?cat?cga?tca?gtt 259

Pro?Gln?Trp?Asn?Glu?Thr?Leu?Asp?Val?Ile?His?Gln?His?Arg?Ser?Val

40 45 50

cgc?agg?tgg?ttg?gat?aaa?ccg?gtt?gat?gat?gac?acc?atc?cgc?acc?att 307

Arg?Arg?Trp?Leu?Asp?Lys?Pro?Val?Asp?Asp?Asp?Thr?Ile?Arg?Thr?Ile

55 60 65

att?tcc?gcc?gca?caa?tcg?gct?gga?acc?tct?tcc?aat?aag?cag?gtc?att 355

Ile?Ser?Ala?Ala?Gln?Ser?Ala?Gly?Thr?Ser?Ser?Asn?Lys?Gln?Val?Ile

70 75 80 85

tct?gtc?atc?gtg?gtt?aaa?gat?cct?gag?ctg?agg?aaa?ggc?ctc?gcg?ggg 403

Ser?Val?Ile?Val?Val?Lys?Asp?Pro?Glu?Leu?Arg?Lys?Gly?Leu?Ala?Gly

90 95 100

atc?act?cgc?cag?atg?ttt?ccg?cac?ctt?gag?cag?gtt?ccc?gcg?gtg?ctg 451

Ile?Thr?Arg?Gln?Met?Phe?Pro?His?Leu?Glu?Gln?Val?Pro?Ala?Val?Leu

105 110 115

att?tgg?ttg?att?gat?tat?tcc?cga?atc?agt?gcg?gtg?gca?gcc?aga?gaa 499

Ile?Trp?Leu?Ile?Asp?Tyr?Ser?Arg?Ile?Ser?Ala?Val?Ala?Ala?Arg?Glu

120 125 130

gat?ctc?cca?aca?ggg?gct?ctt?gat?tat?ctc?gat?gag?gcc?gcg?tgg?ggg 547

Asp?Leu?Pro?Thr?Gly?Ala?Leu?Asp?Tyr?Leu?Asp?Glu?Ala?Ala?Trp?Gly

135 140 145

ttc?ctc?gac?gcc?gga?atc?gca?gct?caa?aac?gct?gca?att?gct?gcg?gag 595

Phe?Leu?Asp?Ala?Gly?Ile?Ala?Ala?Gln?Asn?Ala?Ala?Ile?Ala?Ala?Glu

150 155 160 165

tca?ctt?gga?ttg?gga?acg?ctc?tat?ttg?ggt?tcg?gtg?cgc?aac?gat?gcg 643

Ser?Leu?Gly?Leu?Gly?Thr?Leu?Tyr?Leu?Gly?Ser?Val?Arg?Asn?Asp?Ala

170 175 180

gaa?gcc?gtg?cac?aaa?ttg?ctt?ggc?ctt?cca?cct?gag?atc?gtg?cct?gtc 691

Glu?Ala?Val?His?Lys?Leu?Leu?Gly?Leu?Pro?Pro?Glu?Ile?Val?Pro?Val

185 190 195

gtg?ggc?ttg?gaa?atg?ggg?cat?gcg?gat?ccg?cct?gaa?cct?gcc?gga?att 739

Val?Gly?Leu?Glu?Met?Gly?His?Ala?Asp?Pro?Pro?Glu?Pro?Ala?Gly?Ile

200 205 210

aaa?cct?ccc?ctg?cca?caa?gaa?gcc?att?gtt?cac?tgg?gat?acc?tac?acc 787

Lys?Pro?Pro?Leu?Pro?Gln?Glu?Ala?Ile?Val?His?Trp?Asp?Thr?Tyr?Thr

215 220 225

gag?aaa?aac?ctc?gaa?ctt?atc?gat?tcc?tac?gac?cgc?gcc?ctc?gac?act 835

Glu?Lys?Asn?Leu?Glu?Leu?Ile?Asp?Ser?Tyr?Asp?Arg?Ala?Leu?Asp?Thr

230 235 240 245

tac?tat?tct?cgc?tac?ggc?cag?cac?cag?ctc?tgg?tcg?aag?cag?acg?gcg 883

Tyr?Tyr?Ser?Arg?Tyr?Gly?Gln?His?Gln?Leu?Trp?Ser?Lys?Gln?Thr?Ala

250 255 260

cat?agg?gcg?gcg?tct?aaa?cgc?tgt?tac?aag?aac?caa?gaa 922

His?Arg?Ala?Ala?Ser?Lys?Arg?Cys?Tyr?Lys?Asn?Gln?Glu

265 270

<210>710

<211>274

<212>PRT

＜213〉Corynebacterium glutamicum

<400>710

Met?Gln?Gly?Asn?Ser?Leu?Asn?Leu?Ala?Asp?Asn?Ser?Glu?Arg?Lys?Lys

1 5 10 15

Pro?Met?Pro?Ser?Pro?Gly?Glu?Leu?Leu?Ala?Ala?Arg?Tyr?Gly?Gln?Pro

20 25 30

Ala?Thr?Trp?Thr?Pro?Pro?Gln?Trp?Asn?Glu?Thr?Leu?Asp?Val?Ile?His

35 40 45

Gln?His?Arg?Ser?Val?Arg?Arg?Trp?Leu?Asp?Lys?Pro?Val?Asp?Asp?Asp

50 55 60

Thr?Ile?Arg?Thr?Ile?Ile?Ser?Ala?Ala?Gln?Ser?Ala?Gly?Thr?Ser?Ser

65 70 75 80

Asn?Lys?Gln?Val?Ile?Ser?Val?Ile?Val?Val?Lys?Asp?Pro?Glu?Leu?Arg

85 90 95

Lys?Gly?Leu?Ala?Gly?Ile?Thr?Arg?Gln?Met?Phe?Pro?His?Leu?Glu?Gln

100 105 110

Val?Pro?Ala?Val?Leu?Ile?Trp?Leu?Ile?Asp?Tyr?Ser?Arg?Ile?Ser?Ala

115 120 125

Val?Ala?Ala?Arg?Glu?Asp?Leu?Pro?Thr?Gly?Ala?Leu?Asp?Tyr?Leu?Asp

130 135 140

Glu?Ala?Ala?Trp?Gly?Phe?Leu?Asp?Ala?Gly?Ile?Ala?Ala?Gln?Asn?Ala

145 150 155 160

Ala?Ile?Ala?Ala?Glu?Ser?Leu?Gly?Leu?Gly?Thr?Leu?Tyr?Leu?Gly?Ser

165 170 175

Val?Arg?Asn?Asp?Ala?Glu?Ala?Val?His?Lys?Leu?Leu?Gly?Leu?Pro?Pro

180 185 190

Glu?Ile?Val?Pro?Val?Val?Gly?Leu?Glu?Met?Gly?His?Ala?Asp?Pro?Pro

195 200 205

Glu?Pro?Ala?Gly?Ile?Lys?Pro?Pro?Leu?Pro?Gln?Glu?Ala?Ile?Val?His

210 215 220

Trp?Asp?Thr?Tyr?Thr?Glu?Lys?Asn?Leu?Glu?Leu?Ile?Asp?Ser?Tyr?Asp

225 230 235 240

Arg?Ala?Leu?Asp?Thr?Tyr?Tyr?Ser?Arg?Tyr?Gly?Gln?His?Gln?Leu?Trp

245 250 255

Ser?Lys?Gln?Thr?Ala?His?Arg?Ala?Ala?Ser?Lys?Arg?Cys?Tyr?Lys?Asn

260 265 270

Gln?Glu

<210>711

<211>870

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(847)

<223>RXA01311

<400>711

tcgtctccgc?atgggaacca?ggcgagaatg?gaaccttcgt?ctgccacgca?gaaccactgt?60

tcttcgaatc?tgtcccactg?cagacaagga?actacaagta?atg?aaa?ctt?aca?ctt 115

Met?Lys?Leu?Thr?Leu

1 5

gag?atc?tgg?cgt?caa?gca?ggc?cca?act?gcg?gaa?ggc?aag?ttc?gaa?acc 163

Glu?Ile?Trp?Arg?Gln?Ala?Gly?Pro?Thr?Ala?Glu?Gly?Lys?Phe?Glu?Thr

10 15 20

gtc?cag?gtt?gac?gac?gcc?gtc?gcg?cag?atg?tcc?atc?ctg?gag?ctg?ctt 211

Val?Gln?Val?Asp?Asp?Ala?Val?Ala?Gln?Met?Ser?Ile?Leu?Glu?Leu?Leu

25 30 35

gac?cac?gta?aac?aac?aag?ttc?atc?gaa?gaa?ggc?aaa?gaa?cca?ttc?gcg 259

Asp?His?Val?Asn?Asn?Lys?Phe?Ile?Glu?Glu?Gly?Lys?Glu?Pro?Phe?Ala

40 45 50

ttc?gcc?tct?gac?tgc?cgc?gaa?ggc?att?tgt?ggt?acc?tgt?ggt?ctc?ctc 307

Phe?Ala?Ser?Asp?Cys?Arg?Glu?Gly?Ile?Cys?Gly?Thr?Cys?Gly?Leu?Leu

55 60 65

gtg?aac?ggt?cgc?cct?cac?ggc?gcc?gac?cag?aac?aag?cct?gcc?tgt?gcg 355

Val?ASn?Gly?Arg?Pro?His?Gly?Ala?Asp?Gln?Asn?Lys?Pro?Ala?Cys?Ala

70 75 80 85

cag?cgc?ctg?gtc?agc?tac?aag?gaa?ggc?gac?acc?ctc?aag?atc?gaa?cca 403

Gln?Arg?Leu?Val?Ser?Tyr?Lys?Glu?Gly?Asp?Thr?Leu?Lys?Ile?Glu?Pro

90 95 100

ctg?cgt?tcc?gcc?gca?tac?cca?gtg?atc?aag?gac?atg?gtc?gtc?gac?cgc 451

Leu?Arg?Ser?Ala?Ala?Tyr?Pro?Val?Ile?Lys?Asp?Met?Val?Val?Asp?Arg

105 110 115

tcc?gca?ctg?gac?cgt?gtc?atg?gaa?cag?ggt?ggc?tac?gtg?acc?atc?aac 499

Ser?Ala?Leu?Asp?Arg?Val?Met?Glu?Gln?Gly?Gly?Tyr?Val?Thr?Ile?Asn

120 125 130

gca?ggt?acc?gca?cct?gac?gct?gat?acc?ctc?cac?gtc?aac?cac?gaa?acc 547

Ala?Gly?Thr?Ala?Pro?Asp?Ala?Asp?Thr?Leu?His?Val?Asn?His?Glu?Thr

135 140 145

gca?gaa?ctc?gca?ctt?gac?cac?gca?gcc?tgc?atc?ggc?tgt?ggc?gca?tgt 595

Ala?Glu?Leu?Ala?Leu?Asp?His?Ala?Ala?Cys?Ile?Gly?Cys?Gly?Ala?Cys

150 155 160 165

gtt?gct?gcc?tgc?cct?aac?ggc?gca?gca?cac?ctg?ttc?acc?ggc?gca?aag 643

Val?Ala?Ala?Cys?Pro?Asn?Gly?Ala?Ala?His?Leu?Phe?Thr?Gly?Ala?Lys

170 175 180

ctt?gtt?cac?ctc?tcc?ctc?ctc?cca?ctg?ggt?aag?gaa?gag?cgc?gga?ctg 691

Leu?Val?His?Leu?Ser?Leu?Leu?Pro?Leu?Gly?Lys?Glu?Glu?Arg?Gly?Leu

185 190 195

cgt?gca?cgt?aag?atg?gtt?gat?gaa?atg?gaa?acc?aac?ttc?gga?cac?tgc 739

Arg?Ala?Arg?Lys?Met?Val?Asp?Glu?Met?Glu?Thr?Asn?Phe?Gly?His?Cys

200 205 210

tcc?ctc?tac?ggc?gag?tgc?gca?gat?gtc?tgc?ccc?gca?ggc?atc?cca?ctg 787

Ser?Leu?Tyr?Gly?Glu?Cys?Ala?Asp?Val?Cys?Pro?Ala?Gly?Ile?Pro?Leu

215 220 225

acc?gct?gtg?gca?gct?gtc?acc?aag?gaa?cgt?gcg?cgt?gca?gct?ttc?cga 835

Thr?Ala?Val?Ala?Ala?Val?Thr?Lys?Glu?Arg?Ala?Arg?Ala?Ala?Phe?Arg

230 235 240 245

ggc?aaa?gac?gac?tagtctttaa?tccaagtaag?tac 870

Gly?Lys?Asp?Asp

<210>712

<211>249

<212>PRT

＜213〉Corynebacterium glutamicum

<400>712

Met?Lys?Leu?Thr?Leu?Glu?Ile?Trp?Arg?Gln?Ala?Gly?Pro?Thr?Ala?Glu

1 5 10 15

Gly?Lys?Phe?Glu?Thr?Val?Gln?Val?Asp?Asp?Ala?Val?Ala?Gln?Met?Ser

20 25 30

Ile?Leu?Glu?Leu?Leu?Asp?His?Val?Asn?Asn?Lys?Phe?Ile?Glu?Glu?Gly

35 40 45

Lys?Glu?Pro?Phe?Ala?Phe?Ala?Ser?Asp?Cys?Arg?Glu?Gly?Ile?Cys?Gly

50 55 60

Thr?Cys?Gly?Leu?Leu?Val?Asn?Gly?Arg?Pro?His?Gly?Ala?Asp?Gln?Asn

65 70 75 80

Lys?Pro?Ala?Cys?Ala?Gln?Arg?Leu?Val?Ser?Tyr?Lys?Glu?Gly?Asp?Thr

85 90 95

Leu?Lys?Ile?Glu?Pro?Leu?Arg?Ser?Ala?Ala?Tyr?Pro?Val?Ile?Lys?Asp

100 105 110

Met?Val?Val?Asp?Arg?Ser?Ala?Leu?Asp?Arg?Val?Met?Glu?Gln?Gly?Gly

115 120 125

Tyr?Val?Thr?Ile?Asn?Ala?Gly?Thr?Ala?Pro?Asp?Ala?Asp?Thr?Leu?His

130 135 140

Val?Asn?His?Glu?Thr?Ala?Glu?Leu?Ala?Leu?Asp?His?Ala?Ala?Cys?Ile

145 150 155 160

Gly?Cys?Gly?Ala?Cys?Val?Ala?Ala?Cys?Pro?Asn?Gly?Ala?Ala?His?Leu

165 170 175

Phe?Thr?Gly?Ala?Lys?Leu?Val?His?Leu?Ser?Leu?Leu?Pro?Leu?Gly?Lys

180 185 190

Glu?Glu?Arg?Gly?Leu?Arg?Ala?Arg?Lys?Met?Val?Asp?Glu?Met?Glu?Thr

195 200 205

Asn?Phe?Gly?His?Cys?Ser?Leu?Tyr?Gly?Glu?Cys?Ala?Asp?Val?Cys?Pro

210 215 220

Ala?Gly?Ile?Pro?Leu?Thr?Ala?Val?Ala?Ala?Val?Thr?Lys?Glu?Arg?Ala

225 230 235 240

Arg?Ala?Ala?Phe?Arg?Gly?Lys?Asp?Asp

245

<210>713

<211>929

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(906)

<223>RXN03014

<400>713

tac?gtt?ggt?ttc?gaa?gtg?ctg?ctg?gtg?gcg?tca?tac?gtg?ctg?ctc?acc 48

Tyr?Val?Gly?Phe?Glu?Val?Leu?Leu?Val?Ala?Ser?Tyr?Val?Leu?Leu?Thr

1 5 10 15

ttg?ggt?gca?tcg?ccg?gca?cgt?gta?cgt?tcc?ggc?gtg?ggt?tac?gtg?atg 96

Leu?Gly?Ala?Ser?Pro?Ala?Arg?Val?Arg?Ser?Gly?Val?Gly?Tyr?Val?Met

20 25 30

gtg?tcc?atg?gcg?tca?tcg?atg?gtg?ttc?ctg?ttt?gga?ctc?gca?atg?gtt 144

Val?Ser?Met?Ala?Ser?Ser?Met?Val?Phe?Leu?Phe?Gly?Leu?Ala?Met?Val

35 40 45

tac?gcc?tca?gtg?ggc?acg?ttg?aac?atg?gct?cac?gtt?ggc?cta?cgc?atg 192

Tyr?Ala?Ser?Val?Gly?Thr?Leu?Asn?Met?Ala?His?Val?Gly?Leu?Arg?Met

50 55 60

gaa?gat?gtt?ccg?tct?gga?act?cgc?tcc?gcg?atc?ttc?gca?gtg?ttg?ctc 240

Glu?Asp?Val?Pro?Ser?Gly?Thr?Arg?Ser?Ala?Ile?Phe?Ala?Val?Leu?Leu

65 70 75 80

gtg?gca?ttc?ggt?att?aaa?gct?gcc?gtg?ttc?ccc?cta?gat?tcc?tgg?ctg 288

Val?Ala?Phe?Gly?Ile?Lys?Ala?Ala?Val?Phe?Pro?Leu?Asp?Ser?Trp?Leu

85 90 95

ccg?gac?tcc?tac?ccc?acc?gcg?cca?tcg?ctg?gtc?acc?gcg?gtg?ttc?gca 336

Pro?Asp?Ser?Tyr?Pro?Thr?Ala?Pro?Ser?Leu?Val?Thr?Ala?Val?Phe?Ala

100 105 110

ggt?ctg?ttg?acc?aag?gtg?ggt?gtg?tat?tcc?atc?att?cga?gca?cgc?tcg 384

Gly?Leu?Leu?Thr?Lys?Val?Gly?Val?Tyr?Ser?Ile?Ile?Arg?Ala?Arg?Ser

115 120 125

att?att?ttc?acc?gat?gga?tcc?ctt?gac?acc?atg?ctg?atg?tgg?gtg?gca 432

Ile?Ile?Phe?Thr?Asp?Gly?Ser?Leu?Asp?Thr?Met?Leu?Met?Trp?Val?Ala

130 135 140

ctc?gcc?acc?atg?ctc?att?ggt?att?ttg?ggc?gcg?atg?gcg?caa?aac?gat 480

Leu?Ala?Thr?Met?Leu?Ile?Gly?Ile?Leu?Gly?Ala?Met?Ala?Gln?Asn?Asp

145 150 155 160

atc?aaa?cgt?ttg?ttg?tca?ttt?act?ctg?gtc?agc?cac?atc?ggc?tac?atg 528

Ile?Lys?Arg?Leu?Leu?Ser?Phe?Thr?Leu?Val?Ser?His?Ile?Gly?Tyr?Met

165 170 175

atc?ttc?ggc?gta?gcc?ctt?gga?tct?gca?cag?ggt?ttg?tct?ggt?gcg?atc 576

Ile?Phe?Gly?Val?Ala?Leu?Gly?Ser?Ala?Gln?Gly?Leu?Ser?Gly?Ala?Ile

180 185 190

ttc?tac?gca?atc?cac?cac?att?ctg?gtt?cag?act?tcc?ctg?ttc?ctg?gtg 624

Phe?Tyr?Ala?Ile?His?His?Ile?Leu?Val?Gln?Thr?Ser?Leu?Phe?Leu?Val

195 200 205

gtc?ggt?ctg?gtg?gaa?cgc?caa?gcc?gga?tcc?tcc?tcg?ctg?cga?cgc?ctt 672

Val?Gly?Leu?Val?Glu?Arg?Gln?Ala?Gly?Ser?Ser?Ser?Leu?Arg?Arg?Leu

210 215 220

gga?tcc?ctg?gca?tat?atc?tcc?cca?ctt?ctt?gcg?att?ttg?tac?ttc?atc 720

Gly?Ser?Leu?Ala?Tyr?Ile?Ser?Pro?Leu?Leu?Ala?Ile?Leu?Tyr?Phe?Ile

225 230 235 240

ccc?gcc?atc?aac?ctg?ggt?ggt?atc?cca?ccg?ttc?tcc?ggc?ttc?ctg?ggc 768

Pro?Ala?Ile?Asn?Leu?Gly?Gly?Ile?Pro?Pro?Phe?Ser?Gly?Phe?Leu?Gly

245 250 255

aag?atc?atg?ctc?atc?gaa?gcc?ggc?gcc?cga?aga?tgg?cag?ttg?gct?ggc 816

Lys?Ile?Met?Leu?Ile?Glu?Ala?Gly?Ala?Arg?Arg?Trp?Gln?Leu?Ala?Gly

260 265 270

atg?ggt?cct?tat?cgc?agg?cgc?cgt?tgt?cac?ctc?act?gct?cac?ctt?gta 864

Met?Gly?Pro?Tyr?Arg?Arg?Arg?Arg?Cys?His?Leu?Thr?Ala?His?Leu?Val

275 280 285

cac?cat?ggt?tct?ggt?ctg?gtc?caa?ggc?ctt?ctg?gcg?cga?ccg 906

His?His?Gly?Ser?Gly?Leu?Val?Gln?Gly?Leu?Leu?Ala?Arg?Pro

290 295 300

taaagacgcc?cccgatggag?caa 929

<210>714

<211>302

<212>PRT

＜213〉Corynebacterium glutamicum

<400>714

Tyr?Val?Gly?Phe?Glu?Val?Leu?Leu?Val?Ala?Ser?Tyr?Val?Leu?Leu?Thr

1 5 10 15

Leu?Gly?Ala?Ser?Pro?Ala?Arg?Val?Arg?Ser?Gly?Val?Gly?Tyr?Val?Met

20 25 30

Val?Ser?Met?Ala?Ser?Ser?Met?Val?Phe?Leu?Phe?Gly?Leu?Ala?Met?Val

35 40 45

Tyr?Ala?Ser?Val?Gly?Thr?Leu?Asn?Met?Ala?His?Val?Gly?Leu?Arg?Met

50 55 60

Glu?Asp?Val?Pro?Ser?Gly?Thr?Arg?Ser?Ala?Ile?Phe?Ala?Val?Leu?Leu

65 70 75 80

Val?Ala?Phe?Gly?Ile?Lys?Ala?Ala?Val?Phe?Pro?Leu?Asp?Ser?Trp?Leu

85 90 95

Pro?Asp?Ser?Tyr?Pro?Thr?Ala?Pro?Ser?Leu?Val?Thr?Ala?Val?Phe?Ala

100 105 110

Gly?Leu?Leu?Thr?Lys?Val?Gly?Val?Tyr?Ser?Ile?Ile?Arg?Ala?Arg?Ser

115 120 125

Ile?Ile?Phe?Thr?Asp?Gly?Ser?Leu?Asp?Thr?Met?Leu?Met?Trp?Val?Ala

130 135 140

Leu?Ala?Thr?Met?Leu?Ile?Gly?Ile?Leu?Gly?Ala?Met?Ala?Gln?Asn?Asp

145 150 155 160

Ile?Lys?Arg?Leu?Leu?Ser?Phe?Thr?Leu?Val?Ser?His?Ile?Gly?Tyr?Met

165 170 175

Ile?Phe?Gly?Val?Ala?Leu?Gly?Ser?Ala?Gln?Gly?Leu?Ser?Gly?Ala?Ile

180 185 190

Phe?Tyr?Ala?Ile?His?His?Ile?Leu?Val?Gln?Thr?Ser?Leu?Phe?Leu?Val

195 200 205

Val?Gly?Leu?Val?Glu?Arg?Gln?Ala?Gly?Ser?Ser?Ser?Leu?Arg?Arg?Leu

210 215 220

Gly?Ser?Leu?Ala?Tyr?Ile?Ser?Pro?Leu?Leu?Ala?Ile?Leu?Tyr?Phe?Ile

225 230 235 240

Pro?Ala?Ile?Asn?Leu?Gly?Gly?Ile?Pro?Pro?Phe?Ser?Gly?Phe?Leu?Gly

245 250 255

Lys?Ile?Met?Leu?Ile?Glu?Ala?Gly?Ala?Arg?Arg?Trp?Gln?Leu?Ala?Gly

260 265 270

Met?Gly?Pro?Tyr?Arg?Arg?Arg?Arg?Cys?His?Leu?Thr?Ala?His?Leu?Val

275 280 285

His?His?Gly?Ser?Gly?Leu?Val?Gln?Gly?Leu?Leu?Ala?Arg?Pro

290 295 300

<210>715

<211>1280

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(1257)

<223>FRXA00910

<400>715

tac?gtt?ggt?ttc?gaa?gtg?ctg?ctg?gtg?gcg?tca?tac?gtg?ctg?ctc?acc 48

Tyr?Val?Gly?Phe?Glu?Val?Leu?Leu?Val?Ala?Ser?Tyr?Val?Leu?Leu?Thr

1 5 10 15

ttg?ggt?gca?tcg?ccg?gca?cgt?gta?cgt?tcc?ggc?gtg?ggt?tac?gtg?atg 96

Leu?Gly?Ala?Ser?Pro?Ala?Arg?Val?Arg?Ser?Gly?Val?Gly?Tyr?Val?Met

20 25 30

gtg?tcc?atg?gcg?tca?tcg?atg?gtg?ttc?ctg?ttt?gga?ctc?gca?atg?gtt 144

Val?Ser?Met?Ala?Ser?Ser?Met?Val?Phe?Leu?Phe?Gly?Leu?Ala?Met?Val

35 40 45

tac?gcc?tca?gtg?ggc?acg?ttg?aac?atg?gct?cac?gtt?ggc?cta?cgc?atg 192

Tyr?Ala?Ser?Val?Gly?Thr?Leu?Asn?Met?Ala?His?Val?Gly?Leu?Arg?Met

50 55 60

gaa?gat?gtt?ccg?tct?gga?act?cgc?tcc?gcg?atc?ttc?gca?gtg?ttg?ctc 240

Glu?Asp?Val?Pro?Ser?Gly?Thr?Arg?Ser?Ala?Ile?Phe?Ala?Val?Leu?Leu

65 70 75 80

gtg?gca?ttc?ggt?att?aaa?gct?gcc?gtg?ttc?ccc?cta?gat?tcc?tgg?ctg 288

Val?Ala?Phe?Gly?Ile?Lys?Ala?Ala?Val?Phe?Pro?Leu?Asp?Ser?Trp?Leu

85 90 95

ccg?gac?tcc?tac?ccc?acc?gcg?cca?tcg?ctg?gtc?acc?gcg?gtg?ttc?gca 336

Pro?Asp?Ser?Tyr?Pro?Thr?Ala?Pro?Ser?Leu?Val?Thr?Ala?Val?Phe?Ala

100 105 110

ggt?ctg?ttg?acc?aag?gtg?ggt?gtg?tat?tcc?atc?att?cga?gca?cgc?tcg 384

Gly?Leu?Leu?Thr?Lys?Val?Gly?Val?Tyr?Ser?Ile?Ile?Arg?Ala?Arg?Ser

115 120 125

att?att?ttc?acc?gat?gga?tcc?ctt?gac?acc?atg?ctg?atg?tgg?gtg?gca 432

Ile?Ile?Phe?Thr?Asp?Gly?Ser?Leu?Asp?Thr?Met?Leu?Met?Trp?Val?Ala

130 135 140

ctc?gcc?acc?atg?ctc?att?ggt?att?ttg?ggc?gcg?atg?gcg?caa?aac?gat 480

Leu?Ala?Thr?Met?Leu?Ile?Gly?Ile?Leu?Gly?Ala?Met?Ala?Gln?Asn?Asp

145 150 155 160

atc?aaa?cgt?ttg?ttg?tca?ttt?act?ctg?gtc?agc?cac?atc?ggc?tac?atg 528

Ile?Lys?Arg?Leu?Leu?Ser?Phe?Thr?Leu?Val?Ser?His?Ile?Gly?Tyr?Met

165 170 175

atc?ttc?ggc?gta?gcc?ctt?gga?tct?gca?cag?ggt?ttg?tct?ggt?gcg?atc 576

Ile?Phe?Gly?Val?Ala?Leu?Gly?Ser?Ala?Gln?Gly?Leu?Ser?Gly?Ala?Ile

180 185 190

ttc?tac?gca?atc?cac?cac?att?ctg?gtt?cag?act?tcc?ctg?ttc?ctg?gtg 624

Phe?Tyr?Ala?Ile?His?His?Ile?Leu?Val?Gln?Thr?Ser?Leu?Phe?Leu?Val

195 200 205

gtc?ggt?ctg?gtg?gaa?cgc?caa?gcc?gga?tcc?tcc?tcg?ctg?cga?cgc?ctt 672

Val?Gly?Leu?Val?Glu?Arg?Gln?Ala?Gly?Ser?Ser?Ser?Leu?Arg?Arg?Leu

210 215 220

gga?tcc?ctg?gca?tat?atc?tcc?cca?ctt?ctt?gcg?att?ttg?tac?ttc?atc 720

Gly?Ser?Leu?Ala?Tyr?Ile?Ser?Pro?Leu?Leu?Ala?Ile?Leu?Tyr?Phe?Ile

225 230 235 240

ccc?gcc?atc?aac?ctg?ggt?ggt?atc?cca?ccg?ttc?tcc?ggc?ttc?ctg?ggc 768

Pro?Ala?Ile?Asn?Leu?Gly?Gly?Ile?Pro?Pro?Phe?Ser?Gly?Phe?Leu?Gly

245 250 255

aag?atc?atg?ctc?atc?gaa?gcc?ggc?gcc?gaa?gat?ggc?agt?tgg?ctg?gca 816

Lys?Ile?Met?Leu?Ile?Glu?Ala?Gly?Ala?Glu?Asp?Gly?Ser?Trp?Leu?Ala

260 265 270

tgg?gtc?ctt?atc?gca?ggc?gcc?gtt?gtc?acc?tca?ctg?ctc?acc?ttg?tac 864

Trp?Val?Leu?Ile?Ala?Gly?Ala?Val?Val?Thr?Ser?Leu?Leu?Thr?Leu?Tyr

275 280 285

acc?atg?gtt?ctg?gtc?tgg?tcc?aag?gcc?ttc?tgg?cgc?gac?cgt?aaa?gac 912

Thr?Met?Val?Leu?Val?Trp?Ser?Lys?Ala?Phe?Trp?Arg?Asp?Arg?Lys?Asp

290 295 300

gcc?ccc?gat?gga?gca?acc?gca?ctt?gcg?cga?ccc?gca?cct?ttg?gta?gat 960

Ala?Pro?Asp?Gly?Ala?Thr?Ala?Leu?Ala?Arg?Pro?Ala?Pro?Leu?Val?Asp

305 310 315 320

gtc?caa?gac?gaa?gtc?gcc?gtt?aaa?gac?cgc?aac?gat?gtc?gga?cgg?atg 1008

Val?Gln?Asp?Glu?Val?Ala?Val?Lys?Asp?Arg?Asn?Asp?Val?Gly?Arg?Met

325 330 335

cct?tgg?ggc?atg?gtc?ttc?tcc?act?gct?ctc?ctg?gtt?tca?gca?tct?ctt 1056

Pro?Trp?Gly?Met?Val?Phe?Ser?Thr?Ala?Leu?Leu?Val?Ser?Ala?Ser?Leu

340 345 350

gct?gta?tcc?gtg?ctc?gca?gga?cca?ctg?tca?tct?att?act?gga?cgc?gcc 1104

Ala?Val?Ser?Val?Leu?Ala?Gly?Pro?Leu?Ser?Ser?Ile?Thr?Gly?Arg?Ala

355 360 365

gcc?gaa?tcc?gca?caa?gat?gtc?aac?atc?tac?cgc?gcc?gca?gta?ctc?ggc 1152

Ala?Glu?Ser?Ala?Gln?Asp?Val?Asn?Ile?Tyr?Arg?Ala?Ala?Val?Leu?Gly

370 375 380

ccc?aac?tac?ctc?gac?cca?tca?cgc?aca?ctc?gag?atg?gag?cgt?tac?gac 1200

Pro?Asn?Tyr?Leu?Asp?Pro?Ser?Arg?Thr?Leu?Glu?Met?Glu?Arg?Tyr?Asp

385 390 395 400

gcc?aac?cgc?gat?gac?atc?aac?cac?cgc?gtc?gac?acc?aac?gga?acg?gag 1248

Ala?Asn?Arg?Asp?Asp?Ile?Asn?His?Arg?Val?Asp?Thr?Asn?Gly?Thr?Glu

405 410 415

gac?caa?cca?tgatcagtgg?attcaaacga?cga 1280

Asp?Gln?Pro

<210>716

<211>419

<212>PRT

＜213〉Corynebacterium glutamicum

<400>716

Tyr?Val?Gly?Phe?Glu?Val?Leu?Leu?Val?Ala?Ser?Tyr?Val?Leu?Leu?Thr

1 5 10 15

Leu?Gly?Ala?Ser?Pro?Ala?Arg?Val?Arg?Ser?Gly?Val?Gly?Tyr?Val?Met

20 25 30

Val?Ser?Met?Ala?Ser?Ser?Met?Val?Phe?Leu?Phe?Gly?Leu?Ala?Met?Val

35 40 45

Tyr?Ala?Ser?Val?Gly?Thr?Leu?Asn?Met?Ala?His?Val?Gly?Leu?Arg?Met

50 55 60

Glu?Asp?Val?Pro?Ser?Gly?Thr?Arg?Ser?Ala?Ile?Phe?Ala?Val?Leu?Leu

65 70 75 80

Val?Ala?Phe?Gly?Ile?Lys?Ala?Ala?Val?Phe?Pro?Leu?Asp?Ser?Trp?Leu

85 90 95

Pro?Asp?Ser?Tyr?Pro?Thr?Ala?Pro?Ser?Leu?Val?Thr?Ala?Val?Phe?Ala

100 105 110

Gly?Leu?Leu?Thr?Lys?Val?Gly?Val?Tyr?Ser?Ile?Ile?Arg?Ala?Arg?Ser

115 120 125

Ile?Ile?Phe?Thr?Asp?Gly?Ser?Leu?Asp?Thr?Met?Leu?Met?Trp?Val?Ala

130 135 140

Leu?Ala?Thr?Met?Leu?Ile?Gly?Ile?Leu?Gly?Ala?Met?Ala?Gln?Asn?Asp

145 150 155 160

Ile?Lys?Arg?Leu?Leu?Ser?Phe?Thr?Leu?Val?Ser?His?Ile?Gly?Tyr?Met

165 170 175

Ile?Phe?Gly?Val?Ala?Leu?Gly?Ser?Ala?Gln?Gly?Leu?Ser?Gly?Ala?Ile

180 185 190

Phe?Tyr?Ala?Ile?His?His?Ile?Leu?Val?Gln?Thr?Ser?Leu?Phe?Leu?Val

195 200 205

Val?Gly?Leu?Val?Glu?Arg?Gln?Ala?Gly?Ser?Ser?Ser?Leu?Arg?Arg?Leu

210 215 220

Gly?Ser?Leu?Ala?Tyr?Ile?Ser?Pro?Leu?Leu?Ala?Ile?Leu?Tyr?Phe?Ile

225 230 235 240

Pro?Ala?Ile?Asn?Leu?Gly?Gly?Ile?Pro?Pro?Phe?Ser?Gly?Phe?Leu?Gly

245 250 255

Lys?Ile?Met?Leu?Ile?Glu?Ala?Gly?Ala?Glu?Asp?Gly?Ser?Trp?Leu?Ala

260 265 270

Trp?Val?Leu?Ile?Ala?Gly?Ala?Val?Val?Thr?Ser?Leu?Leu?Thr?Leu?Tyr

275 280 285

Thr?Met?Val?Leu?Val?Trp?Ser?Lys?Ala?Phe?Trp?Arg?Asp?Arg?Lys?Asp

290 295 300

Ala?Pro?Asp?Gly?Ala?Thr?Ala?Leu?Ala?Arg?Pro?Ala?Pro?Leu?Val?Asp

305 310 315 320

Val?Gln?Asp?Glu?Val?Ala?Val?Lys?Asp?Arg?Asn?Asp?Val?Gly?Arg?Met

325 330 335

Pro?Trp?Gly?Met?Val?Phe?Ser?Thr?Ala?Leu?Leu?Val?Ser?Ala?Ser?Leu

340 345 350

Ala?Val?Ser?Val?Leu?Ala?Gly?Pro?Leu?Ser?Ser?Ile?Thr?Gly?Arg?Ala

355 360 365

Ala?Glu?Ser?Ala?Gln?Asp?Val?Asn?Ile?Tyr?Arg?Ala?Ala?Val?Leu?Gly

370 375 380

Pro?Asn?Tyr?Leu?Asp?Pro?Ser?Arg?Thr?Leu?Glu?Met?Glu?Arg?Tyr?Asp

385 390 395 400

Ala?Asn?Arg?Asp?Asp?Ile?Asn?His?Arg?Val?Asp?Thr?Asn?Gly?Thr?Glu

405 410 415

Asp?Gln?Pro

<210>717

<211>1051

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1051)

<223>RXN01895

<400>717

cgcgtacacg?tgctcaacac?gacaacgctt?aaacggctgc?acgcgtaaca?cggcagaccg?60

cacaagcttt?aagatccacg?atcaggagac?tttgacaaat?atg?tca?gtt?aac?cca 115

Met?Ser?Val?Asn?Pro

1 5

acc?cgc?ccc?gaa?ggc?ggc?cgt?cac?cac?gtc?gtc?gtc?atc?ggt?tct?ggt 163

Thr?Arg?Pro?Glu?Gly?Gly?Arg?His?His?Val?Val?Val?Ile?Gly?Ser?Gly

10 15 20

ttt?ggt?ggc?ctt?ttt?gct?gcc?aag?aac?ctg?gcc?aag?gca?gac?gtc?gat 211

Phe?Gly?Gly?Leu?Phe?Ala?Ala?Lys?Asn?Leu?Ala?Lys?Ala?Asp?Val?Asp

25 30 35

gtc?act?ctg?att?gac?cgc?acc?aac?cac?cac?ctc?ttc?cag?cca?ctg?ctg 259

Val?Thr?Leu?Ile?Asp?Arg?Thr?Asn?His?His?Leu?Phe?Gln?Pro?Leu?Leu

40 45 50

tac?caa?gtg?gca?acc?ggt?atc?ctc?tcc?tcc?ggt?gaa?atc?gca?cct?tcc 307

Tyr?Gln?Val?Ala?Thr?Gly?Ile?Leu?Ser?Ser?Gly?Glu?Ile?Ala?Pro?Ser

55 60 65

act?cga?cag?atc?ctg?ggc?tcc?cag?gaa?aac?gtc?aac?gtc?atc?aag?ggc 355

Thr?Arg?Gln?Ile?Leu?Gly?Ser?Gln?Glu?Asn?Val?Asn?Val?Ile?Lys?Gly

70 75 80 85

gaa?gtc?acc?gac?atc?aac?gtc?gag?tcc?cag?act?gtg?acc?gcc?tcc?ctg 403

Glu?Val?Thr?Asp?Ile?Asn?Val?Glu?Ser?Gln?Thr?Val?Thr?Ala?Ser?Leu

90 95 100

ggc?gag?ttc?acc?cgc?gtt?ttt?gag?tac?gat?tcc?ttg?gtc?gtt?ggt?gct 451

Gly?Glu?Phe?Thr?Arg?Val?Phe?Glu?Tyr?Asp?Ser?Leu?Val?Val?Gly?Ala

105 110 115

ggc?gca?ggt?cag?tcc?tac?ttc?ggc?aat?gat?cac?ttc?gct?gag?ttc?gca 499

Gly?Ala?Gly?Gln?Ser?Tyr?Phe?Gly?Asn?Asp?His?Phe?Ala?Glu?Phe?Ala

120 125 130

cct?ggc?atg?aag?tcc?atc?gac?gat?gca?ctg?gag?att?cgt?gca?cgc?atc 547

Pro?Gly?Met?Lys?Ser?Ile?Asp?Asp?Ala?Leu?Glu?Ile?Arg?Ala?Arg?Ile

135 140 145

atc?ggt?gct?ttc?gag?cgc?gct?gag?atc?tgc?gag?gat?cca?gct?gag?cgc 595

Ile?Gly?Ala?Phe?Glu?Arg?Ala?Glu?Ile?Cys?Glu?Asp?Pro?Ala?Glu?Arg

150 155 160 165

gaa?cgc?ctg?ctc?acc?ttc?gtc?gtt?gtt?ggc?gct?ggc?cca?acc?ggt?gtt 643

Glu?Arg?Leu?Leu?Thr?Phe?Val?Val?Val?Gly?Ala?Gly?Pro?Thr?Gly?Val

170 175 180

gag?ctt?gct?ggc?cag?ttg?gct?gag?atg?gct?cac?cgc?acc?ctt?gct?ggt 691

Glu?Leu?Ala?Gly?Gln?Leu?Ala?Glu?Met?Ala?His?Arg?Thr?Leu?Ala?Gly

185 190 195

gag?tac?aag?aac?ttc?aac?acc?aac?tcc?gca?aag?atc?atc?ctg?ctt?gat 739

Glu?Tyr?Lys?Asn?Phe?Asn?Thr?Asn?Ser?Ala?Lys?Ile?Ile?Leu?Leu?Asp

200 205 210

ggt?gct?cca?cag?gtt?ctt?cct?cca?ttc?ggt?aag?cgc?cta?ggc?cgc?aac 787

Gly?Ala?Pro?Gln?Val?Leu?Pro?Pro?Phe?Gly?Lys?Arg?Leu?Gly?Arg?Asn

215 220 225

gca?cag?cgc?acc?ctg?gaa?aag?atg?ggt?gtc?aac?gtt?cgc?ctg?aac?gct 835

Ala?Gln?Arg?Thr?Leu?Glu?Lys?Met?Gly?Val?Asn?Val?Arg?Leu?Asn?Ala

230 235 240 245

atg?gtc?acc?aac?gtt?gac?gct?acc?tcg?gtc?acc?tac?aag?acc?aag?gac 883

Met?Val?Thr?Asn?Val?Asp?Ala?Thr?Ser?Val?Thr?Tyr?Lys?Thr?Lys?Asp

250 255 260

ggc?gaa?gag?cac?acc?atc?gaa?tct?ttc?tgc?aag?att?tgg?tcc?gct?ggt 931

Gly?Glu?Glu?His?Thr?Ile?Glu?Ser?Phe?Cys?Lys?Ile?Trp?Ser?Ala?Gly

265 270 275

gtt?gcg?gca?tcc?cca?ctg?ggc?aag?ctc?gtc?gca?gag?cag?acc?ggt?gtt 979

Val?Ala?Ala?Ser?Pro?Leu?Gly?Lys?Leu?Val?Ala?Glu?Gln?Thr?Gly?Val

280 285 290

gag?acc?gac?cgc?gca?ggc?cgc?gtc?atg?gtt?aac?gat?gac?ctg?tct?gtt 1027

Glu?Thr?Asp?Arg?Ala?Gly?Arg?Val?Met?Val?Asn?Asp?Asp?Leu?Ser?Val

295 300 305

ggc?gat?cag?aag?aac?gtc?ttc?gtt 1051

Gly?Asp?Gln?Lys?Asn?Val?Phe?Val

310 315

<210>718

<211>317

<212>PRT

＜213〉Corynebacterium glutamicum

<400>718

Met?Ser?Val?Asn?Pro?Thr?Arg?Pro?Glu?Gly?Gly?Arg?His?His?Val?Val

1 5 10 15

Val?Ile?Gly?Ser?Gly?Phe?Gly?Gly?Leu?Phe?Ala?Ala?Lys?Asn?Leu?Ala

20 25 30

Lys?Ala?Asp?Val?Asp?Val?Thr?Leu?Ile?Asp?Arg?Thr?Asn?His?His?Leu

35 40 45

Phe?Gln?Pro?Leu?Leu?Tyr?Gln?Val?Ala?Thr?Gly?Ile?Leu?Ser?Ser?Gly

50 55 60

Glu?Ile?Ala?Pro?Ser?Thr?Arg?Gln?Ile?Leu?Gly?Ser?Gln?Glu?Asn?Val

65 70 75 80

Asn?Val?Ile?Lys?Gly?Glu?Val?Thr?Asp?Ile?Asn?Val?Glu?Ser?Gln?Thr

85 90 95

Val?Thr?Ala?Ser?Leu?Gly?Glu?Phe?Thr?Arg?Val?Phe?Glu?Tyr?Asp?Ser

100 105 110

Leu?Val?Val?Gly?Ala?Gly?Ala?Gly?Gln?Ser?Tyr?Phe?Gly?Asn?Asp?His

115 120 125

Phe?Ala?Glu?Phe?Ala?Pro?Gly?Met?Lys?Ser?Ile?Asp?Asp?Ala?Leu?Glu

130 135 140

Ile?Arg?Ala?Arg?Ile?Ile?Gly?Ala?Phe?Glu?Arg?Ala?Glu?Ile?Cys?Glu

145 150 155 160

Asp?Pro?Ala?Glu?Arg?Glu?Arg?Leu?Leu?Thr?Phe?Val?Val?Val?Gly?Ala

165 170 175

Gly?Pro?Thr?Gly?Val?Glu?Leu?Ala?Gly?Gln?Leu?Ala?Glu?Met?Ala?His

180 185 190

Arg?Thr?Leu?Ala?Gly?Glu?Tyr?Lys?Asn?Phe?Asn?Thr?Asn?Ser?Ala?Lys

195 200 205

Ile?Ile?Leu?Leu?Asp?Gly?Ala?Pro?Gln?Val?Leu?Pro?Pro?Phe?Gly?Lys

210 215 220

Arg?Leu?Gly?Arg?Asn?Ala?Gln?Arg?Thr?Leu?Glu?Lys?Met?Gly?Val?Asn

225 230 235 240

Val?Arg?Leu?Asn?Ala?Met?Val?Thr?Asn?Val?Asp?Ala?Thr?Ser?Val?Thr

245 250 255

Tyr?Lys?Thr?Lys?Asp?Gly?Glu?Glu?His?Thr?Ile?Glu?Ser?Phe?Cys?Lys

260 265 270

Ile?Trp?Ser?Ala?Gly?Val?Ala?Ala?Ser?Pro?Leu?Gly?Lys?Leu?Val?Ala

275 280 285

Glu?Gln?Thr?Gly?Val?Glu?Thr?Asp?Arg?Ala?Gly?Arg?Val?Met?Val?Asn

290 295 300

Asp?Asp?Leu?Ser?Val?Gly?Asp?Gln?Lys?Asn?Val?Phe?Val

305 310 315

<210>719

<211>816

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(816)

<223>FRXA01895

<400>719

cac?cac?ctc?ttc?cag?cca?ctg?ctg?tac?caa?gtg?gca?acc?ggt?atc?ctc 48

His?His?Leu?Phe?Gln?Pro?Leu?Leu?Tyr?Gln?Val?Ala?Thr?Gly?Ile?Leu

1 5 10 15

tcc?tcc?ggt?gaa?atc?gca?cct?tcc?act?cga?cag?atc?ctg?ggc?tcc?cag 96

Ser?Ser?Gly?Glu?Ile?Ala?Pro?Ser?Thr?Arg?Gln?Ile?Leu?Gly?Ser?Gln

20 25 30

gaa?aac?gtc?aac?gtc?atc?aag?ggc?gaa?gtc?acc?gac?atc?aac?gtc?gag 144

Glu?Asn?Val?Asn?Val?Ile?Lys?Gly?Glu?Val?Thr?Asp?Ile?Asn?Val?Glu

35 40 45

tcc?cag?act?gtg?acc?gcc?tcc?ctg?ggc?gag?ttc?acc?cgc?gtt?ttt?gag 192

Ser?Gln?Thr?Val?Thr?Ala?Ser?Leu?Gly?Glu?Phe?Thr?Arg?Val?Phe?Glu

50 55 60

tac?gat?tcc?ttg?gtc?gtt?ggt?gct?ggc?gca?ggt?cag?tcc?tac?ttc?ggc 240

Tyr?Asp?Ser?Leu?Val?Val?Gly?Ala?Gly?Ala?Gly?Gln?Ser?Tyr?Phe?Gly

65 70 75 80

aat?gat?cac?ttc?gct?gag?ttc?gca?cct?ggc?atg?aag?tcc?atc?gac?gat 288

Asn?Asp?His?Phe?Ala?Glu?Phe?Ala?Pro?Gly?Met?Lys?Ser?Ile?Asp?Asp

85 90 95

gca?ctg?gag?att?cgt?gca?cgc?atc?atc?ggt?gct?ttc?gag?cgc?gct?gag 336

Ala?Leu?Glu?Ile?Arg?Ala?Arg?Ile?Ile?Gly?Ala?Phe?Glu?Arg?Ala?Glu

100 105 110

atc?tgc?gag?gat?cca?gct?gag?cgc?gaa?cgc?ctg?ctc?acc?ttc?gtc?gtt 384

Ile?Cys?Glu?Asp?Pro?Ala?Glu?Arg?Glu?Arg?Leu?Leu?Thr?Phe?Val?Val

115 120 125

gtt?ggc?gct?ggc?cca?acc?ggt?gtt?gag?ctt?gct?ggc?cag?ttg?gct?gag 432

Val?Gly?Ala?Gly?Pro?Thr?Gly?Val?Glu?Leu?Ala?Gly?Gln?Leu?Ala?Glu

130 135 140

atg?gct?cac?cgc?acc?ctt?gct?ggt?gag?tac?aag?aac?ttc?aac?acc?aac 480

Met?Ala?His?Arg?Thr?Leu?Ala?Gly?Glu?Tyr?Lys?Asn?Phe?Asn?Thr?Asn

145 150 155 160

tcc?gca?aag?atc?atc?ctg?ctt?gat?ggt?gct?cca?cag?gtt?ctt?cct?cca 528

Ser?Ala?Lys?Ile?Ile?Leu?Leu?Asp?Gly?Ala?Pro?Gln?Val?Leu?Pro?Pro

165 170 175

ttc?ggt?aag?cgc?cta?ggc?cgc?aac?gca?cag?cgc?acc?ctg?gaa?aag?atg 576

Phe?GIy?Lys?Arg?Leu?Gly?Arg?Asn?Ala?Gln?Arg?Thr?Leu?Glu?Lys?Met

180 185 190

ggt?gtc?aac?gtt?cgc?ctg?aac?gct?atg?gtc?acc?aac?gtt?gac?gct?acc 624

Gly?Val?Asn?Val?Arg?Leu?Asn?Ala?Met?Val?Thr?Asn?Val?Asp?Ala?Thr

195 200 205

tcg?gtc?acc?tac?aag?acc?aag?gac?ggc?gaa?gag?cac?acc?atc?gaa?tct 672

Ser?Val?Thr?Tyr?Lys?Thr?Lys?Asp?Gly?Glu?Glu?His?Thr?Ile?Glu?Ser

210 215 220

ttc?tgc?aag?att?tgg?tcc?gct?ggt?gtt?gcg?gca?tcc?cca?ctg?ggc?aag 720

Phe?Cys?Lys?Ile?Trp?Ser?Ala?Gly?Val?Ala?Ala?Ser?Pro?Leu?Gly?Lys

225 230 235 240

ctc?gtc?gca?gag?cag?acc?ggt?gtt?gag?acc?gac?cgc?gca?ggc?cgc?gtc 768

Leu?Val?Ala?Glu?Gln?Thr?Gly?Val?Glu?Thr?Asp?Arg?Ala?Gly?Arg?Val

245 250 255

atg?gtt?aac?gat?gac?ctg?tct?gtt?ggc?gat?cag?aag?aac?gtc?ttc?gtt 816

Met?Val?Asn?Asp?Asp?Leu?Ser?Val?Gly?Asp?Gln?Lys?Asn?Val?Phe?Val

260 265 270

<210>720

<211>272

<212>PRT

＜213〉Corynebacterium glutamicum

<400>720

His?His?Leu?Phe?Gln?Pro?Leu?Leu?Tyr?Gln?Val?Ala?Thr?Gly?Ile?Leu

1 5 10 15

Ser?Ser?Gly?Glu?Ile?Ala?Pro?Ser?Thr?Arg?Gln?Ile?Leu?Gly?Ser?Gln

20 25 30

Glu?Asn?Val?Asn?Val?Ile?Lys?Gly?Glu?Val?Thr?Asp?Ile?Asn?Val?Glu

35 40 45

Ser?Gln?Thr?Val?Thr?Ala?Ser?Leu?Gly?Glu?Phe?Thr?Arg?Val?Phe?Glu

50 55 60

Tyr?Asp?Ser?Leu?Val?Val?Gly?Ala?Gly?Ala?Gly?Gln?Ser?Tyr?Phe?Gly

65 70 75 80

Asn?Asp?His?Phe?Ala?Glu?Phe?Ala?Pro?Gly?Met?Lys?Ser?Ile?Asp?Asp

85 90 95

Ala?Leu?Glu?Ile?Arg?Ala?Arg?Ile?Ile?Gly?Ala?Phe?Glu?Arg?Ala?Glu

100 105 110

Ile?Cys?Glu?Asp?Pro?Ala?Glu?Arg?Glu?Arg?Leu?Leu?Thr?Phe?Val?Val

115 120 125

Val?Gly?Ala?Gly?Pro?Thr?Gly?Val?Glu?Leu?Ala?Gly?Gln?Leu?Ala?Glu

130 135 140

Met?Ala?His?Arg?Thr?Leu?Ala?Gly?Glu?Tyr?Lys?Asn?Phe?Asn?Thr?Asn

145 150 155 160

Ser?Ala?Lys?Ile?Ile?Leu?Leu?Asp?Gly?Ala?Pro?Gln?Val?Leu?Pro?Pro

165 170 175

Phe?Gly?Lys?Arg?Leu?Gly?Arg?Asn?Ala?Gln?Arg?Thr?Leu?Glu?Lys?Met

180 185 190

Gly?Val?Asn?Val?Arg?Leu?Asn?Ala?Met?Val?Thr?Asn?Val?Asp?Ala?Thr

195 200 205

Ser?Val?Thr?Tyr?Lys?Thr?Lys?Asp?Gly?Glu?Glu?His?Thr?Ile?Glu?Ser

210 215 220

Phe?Cys?Lys?Ile?Trp?Ser?Ala?Gly?Val?Ala?Ala?Ser?Pro?Leu?Gly?Lys

225 230 235 240

Leu?Val?Ala?Glu?Gln?Thr?Gly?Val?Glu?Thr?Asp?Arg?Ala?Gly?Arg?Val

245 250 255

Met?Val?Asn?Asp?Asp?Leu?Ser?Val?Gly?Asp?Gln?Lys?Asn?Val?Phe?Val

260 265 270

<210>721

<211>2409

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(2386)

<223>RXA00703

<400>721

ctgggagtcc?tcttgatttt?aggttttcca?cataccccca?tatagattga?agaattcatt?60

tttcggcatg?ggttcaattg?ccgggtctag?actgtgacct?atg?aca?acc?cct?cca 115

Met?Thr?Thr?Pro?Pro

1 5

act?gag?att?tcg?aac?gtg?aat?ccc?acc?gcg?aat?gaa?ttt?gat?gat?ccg 163

Thr?Glu?Ile?Ser?Asn?Val?Asn?Pro?Thr?Ala?Asn?Glu?Phe?Asp?Asp?Pro

10 15 20

gat?gtg?gga?cgg?cgc?att?act?tct?gct?gct?ggt?gtg?cca?ggc?gtt?ttg 211

Asp?Val?Gly?Arg?Arg?Ile?Thr?Ser?Ala?Ala?Gly?Val?Pro?Gly?Val?Leu

25 30 35

cat?gcg?ctc?cag?cat?gct?gtt?ccg?aat?cgt?gcc?ctg?ctg?ccg?ttg?ctc 259

His?Ala?Leu?Gln?His?Ala?Val?Pro?Asn?Arg?Ala?Leu?Leu?Pro?Leu?Leu

40 45 50

acc?atg?aat?aaa?cca?ggc?ggc?atc?gac?tgt?cct?ggt?tgt?gct?tgg?cct 307

Thr?Met?Asn?Lys?Pro?Gly?Gly?Ile?Asp?Cys?Pro?Gly?Cys?Ala?Trp?Pro

55 60 65

gag?cct?tcc?act?gcc?aac?ctt?ggt?gtg?gtt?gag?ttc?tgc?gag?aac?ggt 355

Glu?Pro?Ser?Thr?Ala?Asn?Leu?Gly?Val?Val?Glu?Phe?Cys?Glu?Asn?Gly

70 75 80 85

gcc?aag?gcg?gtc?gcc?gag?gaa?aca?aca?cct?gat?cgt?gcc?ggc?aaa?gag 403

Ala?Lys?Ala?Val?Ala?Glu?Glu?Thr?Thr?Pro?Asp?Arg?Ala?Gly?Lys?Glu

90 95 100

ttc?tgg?gca?gag?cat?tct?att?tat?gat?ctg?cgg?gaa?aag?acc?gat?cac 451

Phe?Trp?Ala?Glu?His?Ser?Ile?Tyr?Asp?Leu?Arg?Glu?Lys?Thr?Asp?His

105 110 115

tgg?ctg?gga?aag?cgt?ggc?cga?atc?acc?gag?ccc?atg?ttt?tat?gat?cgt 499

Trp?Leu?Gly?Lys?Arg?Gly?Arg?Ile?Thr?Glu?Pro?Met?Phe?Tyr?Asp?Arg

120 125 130

tct?tct?ggc?gat?gat?cac?tac?cgc?cct?att?tct?tgg?gat?cgt?gca?ttt 547

Ser?Ser?Gly?Asp?Asp?His?Tyr?Arg?Pro?Ile?Ser?Trp?Asp?Arg?Ala?Phe

135 140 145

gcg?atc?att?gcg?tcg?aag?ctc?cgc?gag?atc?gag?cca?gat?gaa?gcg?gtg 595

Ala?Ile?Ile?Ala?Ser?Lys?Leu?Arg?Glu?Ile?Glu?Pro?Asp?Glu?Ala?Val

150 155 160 165

ttt?tac?acc?tct?ggt?cga?gca?ccc?aat?gag?ccg?gct?tat?atg?ctg?cag 643

Phe?Tyr?Thr?Ser?Gly?Arg?Ala?Pro?Asn?Glu?Pro?Ala?Tyr?Met?Leu?Gln

170 175 180

ctt?cta?gcc?cgc?cga?ctt?ggc?aca?aat?aat?ctt?cca?gac?tgt?gga?aac 691

Leu?Leu?Ala?Arg?Arg?Leu?Gly?Thr?Asn?Asn?Leu?Pro?Asp?Cys?Gly?Asn

185 190 195

atg?tgc?cac?gag?tcc?acc?ggt?act?gcc?ttg?ggt?gag?acc?ttg?ggt?ttg 739

Met?Cys?His?Glu?Ser?Thr?Gly?Thr?Ala?Leu?Gly?Glu?Thr?Leu?Gly?Leu

200 205 210

ggc?aag?gga?tcc?gtg?gtg?atg?gag?gat?ttc?tac?aac?act?gat?ttg?ttg 787

Gly?Lys?Gly?Ser?Val?Val?Met?Glu?Asp?Phe?Tyr?Asn?Thr?Asp?Leu?Leu

215 220 225

att?tcc?gtg?gga?caa?aac?ccg?ggc?acc?aac?cac?cca?cgt?gcg?ttg?acg 835

Ile?Ser?Val?Gly?Gln?Asn?Pro?Gly?Thr?Asn?His?Pro?Arg?Ala?Leu?Thr

230 235 240 245

gct?ttc?aaa?gaa?ttg?aag?gaa?aac?ggt?ggc?aag?att?ctg?gcg?ctg?aac 883

Ala?Phe?Lys?Glu?Leu?Lys?Glu?Asn?Gly?Gly?Lys?Ile?Leu?Ala?Leu?Asn

250 255 260

ccc?atg?cca?gag?acc?ggt?ctg?atg?aaa?ttc?cgt?gag?ccc?caa?tca?gtc 931

Pro?Met?Pro?Glu?Thr?Gly?Leu?Met?Lys?Phe?Arg?Glu?Pro?Gln?Ser?Val

265 270 275

aag?ggc?gcg?ttg?agc?att?tca?gac?aaa?ctt?gct?gat?gaa?tac?ttg?cag 979

Lys?Gly?Ala?Leu?Ser?Ile?Ser?Asp?Lys?Leu?Ala?Asp?Glu?Tyr?Leu?Gln

280 285 290

atc?cgt?ctt?gat?gga?gac?cgc?gca?ttc?ttc?cag?gcg?ctc?aac?aag?gaa 1027

Ile?Arg?Leu?Asp?Gly?Asp?Arg?Ala?Phe?Phe?Gln?Ala?Leu?Asn?Lys?Glu

295 300 305

ctc?atc?cgt?aga?gat?gcc?cta?gat?cat?gca?ttc?ttg?gat?aaa?ttc?tgt 1075

Leu?Ile?Arg?Arg?Asp?Ala?Leu?Asp?His?Ala?Phe?Leu?Asp?Lys?Phe?Cys

310 315 320 325

tca?ggt?gtg?gat?gaa?acc?atc?gag?cac?ctc?aaa?tca?ctc?gat?gat?gag 1123

Ser?Gly?Val?Asp?Glu?Thr?Ile?Glu?His?Leu?Lys?Ser?Leu?Asp?Asp?Glu

330 335 340

gtt?ctg?ctc?aag?gga?tgc?ggt?ctg?acg?gca?gcg?gag?atc?aac?aag?gcc 1171

Val?Leu?Leu?Lys?Gly?Cys?Gly?Leu?Thr?Ala?Ala?Glu?Ile?Asn?Lys?Ala

345 350 355

gct?gac?atg?gtg?gaa?aag?tct?gac?acc?gtg?gtg?gtg?tca?tgg?act?ctc 1219

Ala?Asp?Met?Val?Glu?Lys?Ser?Asp?Thr?Val?Val?Val?Ser?Trp?Thr?Leu

360 365 370

ggg?gtc?acc?cag?cat?aag?aac?gct?gtg?tac?acc?atc?cgt?gaa?atg?gtg 1267

Gly?Val?Thr?Gln?His?Lys?Asn?Ala?Val?Tyr?Thr?Ile?Arg?Glu?Met?Val

375 380 385

aac?ttc?ctg?ctg?ctt?act?gga?aat?att?ggt?aag?cct?ggc?gca?ggc?act 1315

Asn?Phe?Leu?Leu?Leu?Thr?Gly?Asn?Ile?Gly?Lys?Pro?Gly?Ala?Gly?Thr

390 395 400 405

gcc?ccg?ctt?cgt?ggg?cac?tca?aac?gtc?cag?ggt?gat?cga?acc?atg?ggt 1363

Ala?Pro?Leu?Arg?Gly?His?Ser?Asn?Val?Gln?Gly?Asp?Arg?Thr?Met?Gly

410 415 420

att?tgg?gag?aaa?atg?ccg?gag?gca?ttc?ctt?gct?gct?ctt?gaa?aac?gag 1411

Ile?Trp?Glu?Lys?Met?Pro?Glu?Ala?Phe?Leu?Ala?Ala?Leu?Glu?Asn?Glu

425 430 435

ttt?ggt?ttc?gat?gtg?ccc?cgc?aag?cac?ggc?ttc?gac?acg?gta?aat?tcc 1459

Phe?Gly?Phe?Asp?Val?Pro?Arg?Lys?His?Gly?Phe?Asp?Thr?Val?Asn?Ser

440 445 450

ctg?cga?gcc?atg?cgc?gaa?ggc?aag?acc?aag?ttc?ttt?ctc?tcc?ctc?ggt 1507

Leu?Arg?Ala?Met?Arg?Glu?Gly?Lys?Thr?Lys?Phe?Phe?Leu?Ser?Leu?Gly

455 460 465

ggc?aac?ctt?gtt?cga?gtg?tcc?tca?gat?acg?tct?gtt?gtc?gaa?aag?ggc 1555

Gly?Asn?Leu?Val?Arg?Val?Ser?Ser?Asp?Thr?Ser?Val?Val?Glu?Lys?Gly

470 475 480 485

atg?gaa?tcc?aat?gag?ctg?acg?gtg?cat?ctg?tcg?acc?aag?ccc?aat?ggt 1603

Met?Glu?Ser?Asn?Glu?Leu?Thr?Val?His?Leu?Ser?Thr?Lys?Pro?Asn?Gly

490 495 500

tca?caa?gca?tgg?cct?ggt?gag?cag?tca?ctt?atc?ctt?ccg?gtg?att?gct 1651

Ser?Gln?Ala?Trp?Pro?Gly?Glu?Gln?Ser?Leu?Ile?Leu?Pro?Val?Ile?Ala

505 510 515

cga?aca?gat?aag?gat?gtc?caa?aag?tca?ggc?gtc?cag?cgt?gtg?aca?gtt 1699

Arg?Thr?Asp?Lys?Asp?Val?Gln?Lys?Ser?Gly?Val?Gln?Arg?Val?Thr?Val

520 525 530

gag?gat?tct?gcc?ggc?gct?gtt?cac?gca?tcc?act?ggt?aaa?cga?acc?gcc 1747

Glu?Asp?Ser?Ala?Gly?Ala?Val?His?Ala?Ser?Thr?Gly?Lys?Arg?Thr?Ala

535 540 545

aac?aag?gat?ctg?aat?ttg?aag?tcc?gaa?tgc?gac?atc?att?gga?acc?atc 1795

Asn?Lys?Asp?Leu?Asn?Leu?Lys?Ser?Glu?Cys?Asp?Ile?Ile?Gly?Thr?Ile

550 555 560 565

ggt?aag?cag?acc?ttc?ggt?gat?gcc?ttc?tgg?cag?ccg?atg?att?gat?aac 1843

Gly?Lys?Gln?Thr?Phe?Gly?Asp?Ala?Phe?Trp?Gln?Pro?Met?Ile?Asp?Asn

570 575 580

tac?gat?gtg?gtc?cgc?gat?cac?atc?gag?gcc?acc?att?cct?ggg?ttc?cac 1891

Tyr?Asp?Val?Val?Arg?Asp?His?Ile?Glu?Ala?Thr?Ile?Pro?Gly?Phe?His

585 590 595

gat?ttc?aac?cgt?cgc?atc?gac?aac?ccc?ggt?gga?ttc?ctc?ctc?ccc?aac 1939

Asp?Phe?Asn?Arg?Arg?Ile?Asp?Asn?Pro?Gly?Gly?Phe?Leu?Leu?Pro?Asn

600 605 610

gga?cct?cgt?gag?cgc?atc?ttc?aac?aca?tcc?aat?ggc?aag?gcc?caa?ttg 1987

Gly?Pro?Arg?Glu?Arg?Ile?Phe?Asn?Thr?Ser?Asn?Gly?Lys?Ala?Gln?Leu

615 620 625

acg?gtt?aat?gaa?acc?aat?gtg?att?gag?cta?ccc?aag?gac?tat?ttg?ctt 2035

Thr?Val?Asn?Glu?Thr?Asn?Val?Ile?Glu?Leu?Pro?Lys?Asp?Tyr?Leu?Leu

630 635 640 645

atg?aac?acg?gta?cgt?tca?cat?gat?caa?tac?aac?tcc?acg?att?tac?ggt 2083

Met?Asn?Thr?Val?Arg?Ser?His?Asp?Gln?Tyr?Asn?Ser?Thr?Ile?Tyr?Gly

650 655 660

ctg?gat?gac?cgc?tac?cgc?ggt?gtt?cgc?aat?ggt?cgc?cgc?gta?gtg?ttc 2131

Leu?Asp?Asp?Arg?Tyr?Arg?Gly?Val?Arg?Asn?Gly?Arg?Arg?Val?Val?Phe

665 670 675

gtc?aat?cct?caa?gat?tgt?aag?caa?cgt?ggt?ctc?aag?gat?gga?gac?atc 2179

Val?Asn?Pro?Gln?Asp?Cys?Lys?Gln?Arg?Gly?Leu?Lys?Asp?Gly?Asp?Ile

680 685 690

gtc?gat?atc?gtc?tct?gtc?ttt?gat?gat?ggc?gaa?cgc?cga?gca?ccg?aat 2227

Val?Asp?Ile?Val?Ser?Val?Phe?Asp?Asp?Gly?Glu?Arg?Arg?Ala?Pro?Asn

695 700 705

ttc?cga?gtg?gtg?gaa?tat?gac?acc?gcg?agg?gac?tgc?gtc?acc?acg?tat 2275

Phe?Arg?Val?Val?Glu?Tyr?Asp?Thr?Ala?Arg?Asp?Cys?Val?Thr?Thr?Tyr

710 715 720 725

ttc?cct?gag?gcc?aac?gta?ttg?gtt?cca?ttg?gat?tca?gta?gct?gaa?aaa 2323

Phe?Pro?Glu?Ala?Asn?Val?Leu?Val?Pro?Leu?Asp?Ser?Val?Ala?Glu?Lys

730 735 740

tcc?aac?act?cca?gtg?tcc?aag?tca?gtt?gtg?gtt?cgc?ctt?gaa?gca?aca 2371

Ser?Asn?Thr?Pro?Val?Ser?Lys?Ser?Val?Val?Val?Arg?Leu?Glu?Ala?Thr

745 750 755

gga?cgt?act?gct?tct?tagaaaaaca?ccagggaatt?ttc 2409

Gly?Arg?Thr?Ala?Ser

760

<210>722

<211>762

<212>PRT

＜213〉Corynebacterium glutamicum

<400>722

Met?Thr?Thr?Pro?Pro?Thr?Glu?Ile?Ser?Asn?Val?Asn?Pro?Thr?Ala?Asn

1 5 10 15

Glu?Phe?Asp?Asp?Pro?Asp?Val?Gly?Arg?Arg?Ile?Thr?Ser?Ala?Ala?Gly

20 25 30

Val?Pro?Gly?Val?Leu?His?Ala?Leu?Gln?His?Ala?Val?Pro?Asn?Arg?Ala

35 40 45

Leu?Leu?Pro?Leu?Leu?Thr?Met?Asn?Lys?Pro?Gly?Gly?Ile?Asp?Cys?Pro

50 55 60

Gly?Cys?Ala?Trp?Pro?Glu?Pro?Ser?Thr?Ala?Asn?Leu?Gly?Val?Val?Glu

65 70 75 80

Phe?Cys?Glu?Asn?Gly?Ala?Lys?Ala?Val?Ala?Glu?Glu?Thr?Thr?Pro?Asp

85 90 95

Arg?Ala?Gly?Lys?Glu?Phe?Trp?Ala?Glu?His?Ser?Ile?Tyr?Asp?Leu?Arg

100 105 110

Glu?Lys?Thr?Asp?His?Trp?Leu?Gly?Lys?Arg?Gly?Arg?Ile?Thr?Glu?Pro

115 120 125

Met?Phe?Tyr?Asp?Arg?Ser?Ser?Gly?Asp?Asp?His?Tyr?Arg?Pro?Ile?Ser

130 135 140

Trp?Asp?Arg?Ala?Phe?Ala?Ile?Ile?Ala?Ser?Lys?Leu?Arg?Glu?Ile?Glu

145 150 155 160

Pro?Asp?Glu?Ala?Val?Phe?Tyr?Thr?Ser?Gly?Arg?Ala?Pro?Asn?Glu?Pro

165 170 175

Ala?Tyr?Met?Leu?Gln?Leu?Leu?Ala?Arg?Arg?Leu?Gly?Thr?Asn?Asn?Leu

180 185 190

Pro?Asp?Cys?Gly?Asn?Met?Cys?His?Glu?Ser?Thr?Gly?Thr?Ala?Leu?Gly

195 200 205

Glu?Thr?Leu?Gly?Leu?Gly?Lys?Gly?Ser?Val?Val?Met?Glu?Asp?Phe?Tyr

210 215 220

Asn?Thr?Asp?Leu?Leu?Ile?Ser?Val?Gly?Gln?Asn?Pro?Gly?Thr?Asn?His

225 230 235 240

Pro?Arg?Ala?Leu?Thr?Ala?Phe?Lys?Glu?Leu?Lys?Glu?Asn?Gly?Gly?Lys

245 250 255

Ile?Leu?Ala?Leu?Asn?Pro?Met?Pro?Glu?Thr?Gly?Leu?Met?Lys?Phe?Arg

260 265 270

Glu?Pro?Gln?Ser?Val?Lys?Gly?Ala?Leu?Ser?Ile?Ser?Asp?Lys?Leu?Ala

275 280 285

Asp?Glu?Tyr?Leu?Gln?Ile?Arg?Leu?Asp?Gly?Asp?Arg?Ala?Phe?Phe?Gln

290 295 300

Ala?Leu?Asn?Lys?Glu?Leu?Ile?Arg?Arg?Asp?Ala?Leu?Asp?His?Ala?Phe

305 310 315 320

Leu?Asp?Lys?Phe?Cys?Ser?Gly?Val?Asp?Glu?Thr?Ile?Glu?His?Leu?Lys

325 330 335

Ser?Leu?Asp?Asp?Glu?Val?Leu?Leu?Lys?Gly?Cys?Gly?Leu?Thr?Ala?Ala

340 345 350

Glu?Ile?Asn?Lys?Ala?Ala?Asp?Met?Val?Glu?Lys?Ser?Asp?Thr?Val?Val

355 360 365

Val?Ser?Trp?Thr?Leu?Gly?Val?Thr?Gln?His?Lys?Asn?Ala?Val?Tyr?Thr

370 375 380

Ile?Arg?Glu?Met?Val?Asn?Phe?Leu?Leu?Leu?Thr?Gly?Asn?Ile?Gly?Lys

385 390 395 400

Pro?Gly?Ala?Gly?Thr?Ala?Pro?Leu?Arg?Gly?His?Ser?Asn?Val?Gln?Gly

405 410 415

Asp?Arg?Thr?Met?Gly?Ile?Trp?Glu?Lys?Met?Pro?Glu?Ala?Phe?Leu?Ala

420 425 430

Ala?Leu?Glu?Asn?Glu?Phe?Gly?Phe?Asp?Val?Pro?Arg?Lys?His?Gly?Phe

435 440 445

Asp?Thr?Val?Asn?Ser?Leu?Arg?Ala?Met?Arg?Glu?Gly?Lys?Thr?Lys?Phe

450 455 460

Phe?Leu?Ser?Leu?Gly?Gly?Asn?Leu?Val?Arg?Val?Ser?Ser?Asp?Thr?Ser

465 470 475 480

Val?Val?Glu?Lys?Gly?Met?Glu?Ser?Asn?Glu?Leu?Thr?Val?His?Leu?Ser

485 490 495

Thr?Lys?Pro?Asn?Gly?Ser?Gln?Ala?Trp?Pro?Gly?Glu?Gln?Ser?Leu?Ile

500 505 510

Leu?Pro?Val?Ile?Ala?Arg?Thr?Asp?Lys?Asp?Val?Gln?Lys?Ser?Gly?Val

515 520 525

Gln?Arg?Val?Thr?Val?Glu?Asp?Ser?Ala?Gly?Ala?Val?His?Ala?Ser?Thr

530 535 540

Gly?Lys?Arg?Thr?Ala?Asn?Lys?Asp?Leu?Asn?Leu?Lys?Ser?Glu?Cys?Asp

545 550 555 560

Ile?Ile?Gly?Thr?Ile?Gly?Lys?Gln?Thr?Phe?Gly?Asp?Ala?Phe?Trp?Gln

565 570 575

Pro?Met?Ile?Asp?Asn?Tyr?Asp?Val?Val?Arg?Asp?His?Ile?Glu?Ala?Thr

580 585 590

Ile?Pro?Gly?Phe?His?Asp?Phe?Asn?Arg?Arg?Ile?Asp?Asn?Pro?Gly?Gly

595 600 605

Phe?Leu?Leu?Pro?Asn?Gly?Pro?Arg?Glu?Arg?Ile?Phe?Asn?Thr?Ser?Asn

610 615 620

Gly?Lys?Ala?Gln?Leu?Thr?Val?Asn?Glu?Thr?Asn?Val?Ile?Glu?Leu?Pro

625 630 635 640

Lys?Asp?Tyr?Leu?Leu?Met?Asn?Thr?Val?Arg?Ser?His?Asp?Gln?Tyr?Asn

645 650 655

Ser?Thr?Ile?Tyr?Gly?Leu?Asp?Asp?Arg?Tyr?Arg?Gly?Val?Arg?Asn?Gly

660 665 670

Arg?Arg?Val?Val?Phe?Val?Asn?Pro?Gln?Asp?Cys?Lys?Gln?Arg?Gly?Leu

675 680 685

Lys?Asp?Gly?Asp?Ile?Val?Asp?Ile?Val?Ser?Val?Phe?Asp?Asp?Gly?Glu

690 695 700

Arg?Arg?Ala?Pro?Asn?Phe?Arg?Val?Val?Glu?Tyr?Asp?Thr?Ala?Arg?Asp

705 710 715 720

Cys?Val?Thr?Thr?Tyr?Phe?Pro?Glu?Ala?Asn?Val?Leu?Val?Pro?Leu?Asp

725 730 735

Ser?Val?Ala?Glu?Lys?Ser?Asn?Thr?Pro?Val?Ser?Lys?Ser?Val?Val?Val

740 745 750

Arg?Leu?Glu?Ala?Thr?Gly?Arg?Thr?Ala?Ser

755 760

<210>723

<211>1038

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1015)

<223>RXN00705

<400>723

gttctggaac?aagcactgat?gattgggccg?agtccacgtt?ggttaatgct?ctgcatcttc?60

aagaaatcat?cgctaaaaat?tacccggagg?ctaaataaaa?atg?ggt?cgg?att?acc 115

Met?Gly?Arg?Ile?Thr

1 5

caa?aac?ttg?cag?gtc?cca?cgc?gtt?gtg?tcc?act?gac?gag?caa?gtt?ttt 163

Gln?Asn?Leu?Gln?Val?Pro?Arg?Val?Val?Ser?Thr?Asp?Glu?Gln?Val?Phe

10 15 20

gtt?aac?act?cgt?ccg?gat?act?gtt?gcg?gtg?gag?gag?cct?cta?gaa?att 211

Val?Asn?Thr?Arg?Pro?Asp?Thr?Val?Ala?Val?Glu?Glu?Pro?Leu?Glu?Ile

25 30 35

cgg?gtt?aat?ggc?act?gcg?ctt?acc?acc?act?atg?cgc?acg?ccc?ggc?cat 259

Arg?Val?Asn?Gly?Thr?Ala?Leu?Thr?Thr?Thr?Met?Arg?Thr?Pro?Gly?His

40 45 50

gat?att?gag?ttg?gtg?cat?ggc?ctc?ctc?ttg?tca?gaa?ggt?ctg?atc?acg 307

Asp?Ile?Glu?Leu?Val?His?Gly?Leu?Leu?Leu?Ser?Glu?Gly?Leu?Ile?Thr

55 60 65

gat?gct?tct?gag?gtt?ttt?acc?gcc?cgc?tat?tgt?gca?gga?gct?gtt?ggc 355

Asp?Ala?Ser?Glu?Val?Phe?Thr?Ala?Arg?Tyr?Cys?Ala?Gly?Ala?Val?Gly

70 75 80 85

cca?gat?aat?caa?aat?acg?tac?aac?gtc?tta?gaa?ctt?gat?gtc?atc?ccc 403

Pro?Asp?Asn?Gln?Asn?Thr?Tyr?Asn?Val?Leu?Glu?Leu?Asp?Val?Ile?Pro

90 95 100

aaa?gac?aat?ccg?gcc?cgg?gat?ccc?gtc?cag?aat?ccc?tcc?cat?aat?ccc 451

Lys?Asp?Asn?Pro?Ala?Arg?Asp?Pro?Val?Gln?Asn?Pro?Ser?His?Asn?Pro

105 110 115

gaa?ggc?agc?caa?cac?gaa?gca?ctc?cac?atc?cca?act?ttc?caa?ccg?gta 499

Glu?Gly?Ser?Gln?His?Glu?Ala?Leu?His?Ile?Pro?Thr?Phe?Gln?Pro?Val

120 125 130

cgc?gaa?cta?aac?ctc?gtg?gca?gcc?caa?cgc?aat?gtg?ctg?act?acg?tct 547

Arg?Glu?Leu?Asn?Leu?Val?Ala?Ala?Gln?Arg?Asn?Val?Leu?Thr?Thr?Ser

135 140 145

gct?tgt?ggt?gtt?tgt?ggc?acg?acg?tct?att?gag?cag?ttg?atg?aac?aag 595

Ala?Cys?Gly?Val?Cys?Gly?Thr?Thr?Ser?Ile?Glu?Gln?Leu?Met?Asn?Lys

150 155 160 165

aag?ggc?tgg?ccc?att?acg?ccg?att?aca?ccg?gat?cct?cgg?atg?att?gtg 643

Lys?Gly?Trp?Pro?Ile?Thr?Pro?Ile?Thr?Pro?Asp?Pro?Arg?Met?Ile?Val

170 175 180

tcg?ttg?cca?gat?aag?ttg?aag?tcg?aag?cag?aag?att?ttc?gac?aaa?act 691

Ser?Leu?Pro?Asp?Lys?Leu?Lys?Ser?Lys?Gln?Lys?Ile?Phe?Asp?Lys?Thr

185 190 195

ggt?ggg?gtt?cat?gct?gct?ggt?ttg?gcc?acg?ctt?gat?ggt?gag?atg?ttg 739

Gly?Gly?Val?His?Ala?Ala?Gly?Leu?Ala?Thr?Leu?Asp?Gly?Glu?Met?Leu

200 205 210

att?att?cga?gag?gat?gtc?ggt?cgg?cat?aac?gca?gct?gac?aaa?gtt?ata 787

Ile?Ile?Arg?Glu?Asp?Val?Gly?Arg?His?Asn?Ala?Ala?Asp?Lys?Val?Ile

215 220 225

gga?aac?atg?ctg?atg?gcg?gga?aag?ctc?ccc?ttg?gaa?aac?act?att?ttg 835

Gly?Asn?Met?Leu?Met?Ala?Gly?Lys?Leu?Pro?Leu?Glu?Asn?Thr?Ile?Leu

230 235 240 245

gtg?atg?agt?tct?agg?gcg?tct?ttt?gag?ctt?gtc?caa?aag?gct?gcc?atg 883

Val?Met?Ser?Ser?Arg?Ala?Ser?Phe?Glu?Leu?Val?Gln?Lys?Ala?Ala?Met

250 255 260

gct?gga?att?tcg?ggt?gta?atc?gct?gtt?ggt?gct?gca?aca?tcg?ctg?gca 931

Ala?Gly?Ile?Ser?Gly?Val?Ile?Ala?Val?Gly?Ala?Ala?Thr?Ser?Leu?Ala

265 270 275

atc?gag?gcg?gcg?cag?gat?tca?ggt?att?ttc?ctt?gct?ggt?ttt?gtt?cgg 979

Ile?Glu?Ala?Ala?Gln?Asp?Ser?Gly?Ile?Phe?Leu?Ala?Gly?Phe?Val?Arg

280 285 290

ggc?aac?aag?ttt?aac?cac?tat?gcg?ggc?gag?ctc?gga?taatgccaga 1025

Gly?Asn?Lys?Phe?Asn?His?Tyr?Ala?Gly?Glu?Leu?Gly

295 300 305

acaggtagaa?cag 1038

<210>724

<211>305

<212>PRT

＜213〉Corynebacterium glutamicum

<400>724

Met?Gly?Arg?Ile?Thr?Gln?Asn?Leu?Gln?Val?Pro?Arg?Val?Val?Ser?Thr

1 5 10 15

Asp?Glu?Gln?Val?Phe?Val?Asn?Thr?Arg?Pro?Asp?Thr?Val?Ala?Val?Glu

20 25 30

Glu?Pro?Leu?Glu?Ile?Arg?Val?Asn?Gly?Thr?Ala?Leu?Thr?Thr?Thr?Met

35 40 45

Arg?Thr?Pro?Gly?His?Asp?Ile?Glu?Leu?Val?His?Gly?Leu?Leu?Leu?Ser

50 55 60

Glu?Gly?Leu?Ile?Thr?Asp?Ala?Ser?Glu?Val?Phe?Thr?Ala?Arg?Tyr?Cys

65 70 75 80

Ala?Gly?Ala?Val?Gly?Pro?Asp?Asn?Gln?Asn?Thr?Tyr?Asn?Val?Leu?Glu

85 90 95

Leu?Asp?Val?Ile?Pro?Lys?Asp?Asn?Pro?Ala?Arg?Asp?Pro?Val?Gln?Asn

100 105 110

Pro?Ser?His?Asn?Pro?Glu?Gly?Ser?Gln?His?Glu?Ala?Leu?His?Ile?Pro

115 120 125

Thr?Phe?Gln?Pro?Val?Arg?Glu?Leu?Asn?Leu?Val?Ala?Ala?Gln?Arg?Asn

130 135 140

Val?Leu?Thr?Thr?Ser?Ala?Cys?Gly?Val?Cys?Gly?Thr?Thr?Ser?Ile?Glu

145 150 155 160

Gln?Leu?Met?Asn?Lys?Lys?Gly?Trp?Pro?Ile?Thr?Pro?Ile?Thr?Pro?Asp

165 170 175

Pro?Arg?Met?Ile?Val?Ser?Leu?Pro?Asp?Lys?Leu?Lys?Ser?Lys?Gln?Lys

180 185 190

Ile?Phe?Asp?Lys?Thr?Gly?Gly?Val?His?Ala?Ala?Gly?Leu?Ala?Thr?Leu

195 200 205

Asp?Gly?Glu?Met?Leu?Ile?Ile?Arg?Glu?Asp?Val?Gly?Arg?His?Asn?Ala

210 215 220

Ala?Asp?Lys?Val?Ile?Gly?Asn?Met?Leu?Met?Ala?Gly?Lys?Leu?Pro?Leu

225 230 235 240

Glu?Asn?Thr?Ile?Leu?Val?Met?Ser?Ser?Arg?Ala?Ser?Phe?Glu?Leu?Val

245 250 255

Gln?Lys?Ala?Ala?Met?Ala?Gly?Ile?Ser?Gly?Val?Ile?Ala?Val?Gly?Ala

260 265 270

Ala?Thr?Ser?Leu?Ala?Ile?Glu?Ala?Ala?Gln?Asp?Ser?Gly?Ile?Phe?Leu

275 280 285

Ala?Gly?Phe?Val?Arg?Gly?Asn?Lys?Phe?Asn?His?Tyr?Ala?Gly?Glu?Leu

290 295 300

Gly

305

<210>725

<211>908

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(885)

<223>FRXA00705

<400>725

cca?cgc?gtt?gtg?tcc?act?gac?gag?caa?gtt?ttt?gtt?aac?act?cgt?ccg 48

Pro?Arg?Val?Val?Ser?Thr?Asp?Glu?Gln?Val?Phe?Val?Asn?Thr?Arg?Pro

1 5 10 15

gat?act?gtt?gcg?gtg?gag?gag?cct?cta?gaa?att?cgg?gtt?aat?ggc?act 96

Asp?Thr?Val?Ala?Val?Glu?Glu?Pro?Leu?Glu?Ile?Arg?Val?Asn?Gly?Thr

20 25 30

gcg?ctt?acc?acc?act?atg?cgc?acg?ccc?ggc?cat?gat?att?gag?ttg?gtg 144

Ala?Leu?Thr?Thr?Thr?Met?Arg?Thr?Pro?Gly?His?Asp?Ile?Glu?Leu?Val

35 40 45

cat?ggc?ctc?ctc?ttg?tca?gaa?ggt?ctg?atc?acg?gat?gct?tct?gag?gtt 192

His?Gly?Leu?Leu?Leu?Ser?Glu?Gly?Leu?Ile?Thr?Asp?Ala?Ser?Glu?Val

50 55 60

ttt?acc?gcc?cgc?tat?tgt?gca?gga?gct?gtt?ggc?cca?gat?aat?caa?aat 240

Phe?Thr?Ala?Arg?Tyr?Cys?Ala?Gly?Ala?Val?Gly?Pro?Asp?Asn?Gln?Asn

65 70 75 80

acg?tac?aac?gtc?tta?gaa?ctt?gat?gtc?atc?ccc?aaa?gac?aat?ccg?gcc 288

Thr?Tyr?Asn?Val?Leu?Glu?Leu?Asp?Val?Ile?Pro?Lys?Asp?Asn?Pro?Ala

85 90 95

cgg?gat?ccc?gtc?cag?aat?ccc?tcc?cat?aat?ccc?gaa?ggc?agc?caa?cac 336

Arg?Asp?Pro?Val?Gln?Asn?Pro?Ser?His?Asn?Pro?Glu?Gly?Ser?Gln?His

100 105 110

gaa?gca?ctc?cac?atc?cca?act?ttc?caa?ccg?gta?cgc?gaa?cta?aac?ctc 384

Glu?Ala?Leu?His?Ile?Pro?Thr?Phe?Gln?Pro?Val?Arg?Glu?Leu?Asn?Leu

115 120 125

gtg?gca?gcc?caa?cgc?aat?gtg?ctg?act?acg?tct?gct?tgt?ggt?gtt?tgt 432

Val?Ala?Ala?Gln?Arg?Asn?Val?Leu?Thr?Thr?Ser?Ala?Cys?Gly?Val?Cys

130 135 140

ggc?acg?acg?tct?att?gag?cag?ttg?atg?aac?aag?aag?ggc?tgg?ccc?att 480

Gly?Thr?Thr?Ser?Ile?Glu?Gln?Leu?Met?Asn?Lys?Lys?Gly?Trp?Pro?Ile

145 150 155 160

acg?ccg?att?aca?ccg?gat?cct?cgg?atg?att?gtg?tcg?ttg?cca?gat?aag 528

Thr?Pro?Ile?Thr?Pro?Asp?Pro?Arg?Met?Ile?Val?Ser?Leu?Pro?Asp?Lys

165 170 175

ttg?aag?tcg?aag?cag?aag?att?ttc?gac?aaa?act?ggt?ggg?gtt?cat?gct 576

Leu?Lys?Ser?Lys?Gln?Lys?Ile?Phe?Asp?Lys?Thr?Gly?Gly?Val?His?Ala

180 185 190

gct?ggt?ttg?gcc?acg?ctt?gat?ggt?gag?atg?ttg?att?att?cga?gag?gat 624

Ala?Gly?Leu?Ala?Thr?Leu?Asp?Gly?Glu?Met?Leu?Ile?Ile?Arg?Glu?Asp

195 200 205

gtc?ggt?cgg?cat?aac?gca?gct?gac?aaa?gtt?ata?gga?aac?atg?ctg?atg 672

Val?Gly?Arg?His?Asn?Ala?Ala?Asp?Lys?Val?Ile?Gly?Asn?Met?Leu?Met

210 215 220

gcg?gga?aag?ctc?ccc?ttg?gaa?aac?act?att?ttg?gtg?atg?agt?tct?agg 720

Ala?Gly?Lys?Leu?Pro?Leu?Glu?Asn?Thr?Ile?Leu?Val?Met?Ser?Ser?Arg

225 230 235 240

gcg?tct?ttt?gag?ctt?gtc?caa?aag?gct?gcc?atg?gct?gga?att?tcg?ggt 768

Ala?Ser?Phe?Glu?Leu?Val?Gln?Lys?Ala?Ala?Met?Ala?Gly?Ile?Ser?Gly

245 250 255

gta?atc?gct?gtt?ggt?gct?gca?aca?tcg?ctg?gca?atc?gag?gcg?gcg?cag 816

Val?Ile?Ala?Val?Gly?Ala?Ala?Thr?Ser?Leu?Ala?Ile?Glu?Ala?Ala?Gln

260 265 270

gat?tca?ggt?att?ttc?ctt?gct?ggt?ttt?gtt?cgg?ggc?aac?aag?ttt?aac 864

Asp?Ser?Gly?Ile?Phe?Leu?Ala?Gly?Phe?Val?Arg?Gly?Asn?Lys?Phe?Asn

275 280 285

cac?tat?gcg?ggc?gag?ctc?gga?taatgccaga?acaggtagaa?cag 908

His?Tyr?Ala?Gly?Glu?Leu?Gly

290 295

<210>726

<211>295

<212>PRT

＜213〉Corynebacterium glutamicum

<400>726

Pro?Arg?Val?Val?Ser?Thr?Asp?Glu?Gln?Val?Phe?Val?Asn?Thr?Arg?Pro

1 5 10 15

Asp?Thr?Val?Ala?Val?Glu?Glu?Pro?Leu?Glu?Ile?Arg?Val?Asn?Gly?Thr

20 25 30

Ala?Leu?Thr?Thr?Thr?Met?Arg?Thr?Pro?Gly?His?Asp?Ile?Glu?Leu?Val

35 40 45

His?Gly?Leu?Leu?Leu?Ser?Glu?Gly?Leu?Ile?Thr?Asp?Ala?Ser?Glu?Val

50 55 60

Phe?Thr?Ala?Arg?Tyr?Cys?Ala?Gly?Ala?Val?Gly?Pro?Asp?Asn?Gln?Asn

65 70 75 80

Thr?Tyr?Asn?Val?Leu?Glu?Leu?Asp?Val?Ile?Pro?Lys?Asp?Asn?Pro?Ala

85 90 95

Arg?Asp?Pro?Val?Gln?Asn?Pro?Ser?His?Asn?Pro?Glu?Gly?Ser?Gln?His

100 105 110

Glu?Ala?Leu?His?Ile?Pro?Thr?Phe?Gln?Pro?Val?Arg?Glu?Leu?Asn?Leu

115 120 125

Val?Ala?Ala?Gln?Arg?Asn?Val?Leu?Thr?Thr?Ser?Ala?Cys?Gly?Val?Cys

130 135 140

Gly?Thr?Thr?Ser?Ile?Glu?Gln?Leu?Met?Asn?Lys?Lys?Gly?Trp?Pro?Ile

145 150 155 160

Thr?Pro?Ile?Thr?Pro?Asp?Pro?Arg?Met?Ile?Val?Ser?Leu?Pro?Asp?Lys

165 170 175

Leu?Lys?Ser?Lys?Gln?Lys?Ile?Phe?Asp?Lys?Thr?Gly?Gly?Val?His?Ala

180 185 190

Ala?Gly?Leu?Ala?Thr?Leu?Asp?Gly?Glu?Met?Leu?Ile?Ile?Arg?Glu?Asp

195 200 205

Val?Gly?Arg?His?Asn?Ala?Ala?Asp?Lys?Val?Ile?Gly?Asn?Met?Leu?Met

210 215 220

Ala?Gly?Lys?Leu?Pro?Leu?Glu?Asn?Thr?Ile?Leu?Val?Met?Ser?Ser?Arg

225 230 235 240

Ala?Ser?Phe?Glu?Leu?Val?Gln?Lys?Ala?Ala?Met?Ala?Gly?Ile?Ser?Gly

245 250 255

Val?Ile?Ala?Val?Gly?Ala?Ala?Thr?Ser?Leu?Ala?Ile?Glu?Ala?Ala?Gln

260 265 270

Asp?Ser?Gly?Ile?Phe?Leu?Ala?Gly?Phe?Val?Arg?Gly?Asn?Lys?Phe?Asn

275 280 285

His?Tyr?Ala?Gly?Glu?Leu?Gly

290 295

<210>727

<211>1134

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1111)

<223>RXN00388

<400>727

gaagagtact?tcgaccacga?cgactaacac?cgcaatttaa?aggcttttca?agcctgcccc?60

acatcgaagc?agttttcaca?aagaataagg?ttggaaaatt?atg?ttg?ccc?gtc?aac 115

Met?Leu?Pro?Val?Asn

1 5

caa?acg?tat?gcg?cag?ttc?tca?gac?act?gcc?ttc?gta?tcg?gca?tac?atc 163

Gln?Thr?Tyr?Ala?Gln?Phe?Ser?Asp?Thr?Ala?Phe?Val?Ser?Ala?Tyr?Ile

10 15 20

atc?tac?gtt?ctg?gca?ctc?atc?ctc?tcc?ctc?gtc?tac?tac?gta?aaa?caa 211

Ile?Tyr?Val?Leu?Ala?Leu?Ile?Leu?Ser?Leu?Val?Tyr?Tyr?Val?Lys?Gln

25 30 35

caa?ggc?att?atc?gac?gcc?cgc?cgc?gag?caa?acc?cgc?gtc?agc?gaa?ctc 259

Gln?Gly?Ile?Ile?Asp?Ala?Arg?Arg?Glu?Gln?Thr?Arg?Val?Ser?Glu?Leu

40 45 50

gtt?ggt?gca?ggc?ggc?agc?gct?gat?gtt?gat?act?gac?ctg?cct?gat?gac 307

Val?Gly?Ala?Gly?Gly?Ser?Ala?Asp?Val?Asp?Thr?Asp?Leu?Pro?Asp?Asp

55 60 65

atc?gcc?gac?ggt?gtc?ctc?gcc?gac?gaa?gac?ctt?gca?aaa?cgc?gaa?gaa 355

Ile?Ala?Asp?Gly?Val?Leu?Ala?Asp?Glu?Asp?Leu?Ala?Lys?Arg?Glu?Glu

70 75 80 85

acc?gca?cgc?aaa?cta?gcc?aac?atg?acc?caa?tct?ctc?atg?tgg?ctc?ggc 403

Thr?Ala?Arg?Lys?Leu?Ala?Asn?Met?Thr?Gln?Ser?Leu?Met?Trp?Leu?Gly

90 95 100

gtc?atg?gtg?cac?ctc?gta?tcc?gtc?gtg?atg?cgc?gcg?ctg?tct?gcc?agc 451

Val?Met?Val?His?Leu?Val?Ser?Val?Val?Met?Arg?Ala?Leu?Ser?Ala?Ser

105 110 115

cga?ttc?ccc?ttc?ggc?aac?ctg?tat?gaa?tac?atc?ctc?atg?gtc?acc?ctc 499

Arg?Phe?Pro?Phe?Gly?Asn?Leu?Tyr?Glu?Tyr?Ile?Leu?Met?Val?Thr?Leu

120 125 130

ttc?gcc?atg?atc?gga?gcc?gta?ctc?atc?ctg?cag?cgc?cca?caa?ttc?cgc 547

Phe?Ala?Met?Ile?Gly?Ala?Val?Leu?Ile?Leu?Gln?Arg?Pro?Gln?Phe?Arg

135 140 145

gtg?gta?tgg?cca?tgg?atc?ctc?acc?cca?atg?ctg?gca?ctg?ctc?ttc?tac 595

Val?Val?Trp?Pro?Trp?Ile?Leu?Thr?Pro?Met?Leu?Ala?Leu?Leu?Phe?Tyr

150 155 160 165

ggt?ggc?acc?cag?ctg?tac?tcc?gac?gca?gca?cca?gtc?gtt?cca?gca?ctg 643

Gly?Gly?Thr?Gln?Leu?Tyr?Ser?Asp?Ala?Ala?Pro?Val?Val?Pro?Ala?Leu

170 175 180

cag?tcc?ttc?tgg?ttc?ccg?atc?cac?gtt?tcc?tcc?gtc?tcc?atc?ggc?gca 691

Gln?Ser?Phe?Trp?Phe?Pro?Ile?His?Val?Ser?Ser?Val?Ser?Ile?Gly?Ala

185 190 195

tcc?atc?ggt?atc?gtc?tcc?ggt?att?gca?tcc?ctg?ctg?tac?ata?ctg?cgc 739

Ser?Ile?Gly?Ile?Val?Ser?Gly?Ile?Ala?Ser?Leu?Leu?Tyr?Ile?Leu?Arg

200 205 210

atg?tgg?caa?cca?aag?ggt?aaa?gaa?aag?ggc?ttc?ttc?ggc?gca?gta?gca 787

Met?Trp?Gln?Pro?Lys?Gly?Lys?Glu?Lys?Gly?Phe?Phe?Gly?Ala?Val?Ala

215 220 225

aaa?cca?ctc?cca?tcc?gga?aaa?acc?ctg?gat?aac?ctg?gca?tac?aag?acc 835

Lys?Pro?Leu?Pro?Ser?Gly?Lys?Thr?Leu?Asp?Asn?Leu?Ala?Tyr?Lys?Thr

230 235 240 245

gcg?atc?tgg?act?gtc?cca?atc?ttc?ggc?ctg?ggc?atc?atc?ttg?ggt?gcc 883

Ala?Ile?Trp?Thr?Val?Pro?Ile?Phe?Gly?Leu?Gly?Ile?Ile?Leu?Gly?Ala

250 255 260

atc?tgg?gca?gaa?gca?gcc?tgg?ggt?cgt?ttc?tgg?gga?tgg?gat?cct?aag 931

Ile?Trp?Ala?Glu?Ala?Ala?Trp?Gly?Arg?Phe?Trp?Gly?Trp?Asp?Pro?Lys

265 270 275

gaa?aca?gtc?tcc?ttc?atc?acc?tgg?gtt?ctc?tac?gct?ggt?tac?ctc?cac 979

Glu?Thr?Val?Ser?Phe?Ile?Thr?Trp?Val?Leu?Tyr?Ala?Gly?Tyr?Leu?His

280 285 290

gca?cgt?gca?act?gct?ggt?tgg?cgc?aac?acc?aac?gct?gca?tgg?atc?aac 1027

Ala?Arg?Ala?Thr?Ala?Gly?Trp?Arg?Asn?Thr?Asn?Ala?Ala?Trp?Ile?Asn

295 300 305

atc?ctg?gcg?ctg?gtc?acg?atg?att?ttt?aat?ctg?ttc?ttc?atc?aac?atg 1075

Ile?Leu?Ala?Leu?Val?Thr?Met?Ile?Phe?Asn?Leu?Phe?Phe?Ile?Asn?Met

310 315 320 325

gtc?gta?tct?ggt?ctg?cac?tct?tac?gcc?gga?ctg?aac?taagcacttt 1121

Val?Val?Ser?Gly?Leu?His?Ser?Tyr?Ala?Gly?Leu?Asn

330 335

tggttggcgg?ggt 1134

<210>728

<211>337

<212>PRT

＜213〉Corynebacterium glutamicum

<400>728

Met?Leu?Pro?Val?Asn?Gln?Thr?Tyr?Ala?Gln?Phe?Ser?Asp?Thr?Ala?Phe

1 5 10 15

Val?Ser?Ala?Tyr?Ile?Ile?Tyr?Val?Leu?Ala?Leu?Ile?Leu?Ser?Leu?Val

20 25 30

Tyr?Tyr?Val?Lys?Gln?Gln?Gly?Ile?Ile?Asp?Ala?Arg?Arg?Glu?Gln?Thr

35 40 45

Arg?Val?Ser?Glu?Leu?Val?Gly?Ala?Gly?Gly?Ser?Ala?Asp?Val?Asp?Thr

50 55 60

Asp?Leu?Pro?Asp?Asp?Ile?Ala?Asp?Gly?Val?Leu?Ala?Asp?Glu?Asp?Leu

65 70 75 80

Ala?Lys?Arg?Glu?Glu?Thr?Ala?Arg?Lys?Leu?Ala?Asn?Met?Thr?Gln?Ser

85 90 95

Leu?Met?Trp?Leu?Gly?Val?Met?Val?His?Leu?Val?Ser?Val?Val?Met?Arg

100 105 110

Ala?Leu?Ser?Ala?Ser?Arg?Phe?Pro?Phe?Gly?Asn?Leu?Tyr?Glu?Tyr?Ile

115 120 125

Leu?Met?Val?Thr?Leu?Phe?Ala?Met?Ile?Gly?Ala?Val?Leu?Ile?Leu?Gln

130 135 140

Arg?Pro?Gln?Phe?Arg?Val?Val?Trp?Pro?Trp?Ile?Leu?Thr?Pro?Met?Leu

145 150 155 160

Ala?Leu?Leu?Phe?Tyr?Gly?Gly?Thr?Gln?Leu?Tyr?Ser?Asp?Ala?Ala?Pro

165 170 175

Val?Val?Pro?Ala?Leu?Gln?Ser?Phe?Trp?Phe?Pro?Ile?His?Val?Ser?Ser

180 185 190

Val?Ser?Ile?Gly?Ala?Ser?Ile?Gly?Ile?Val?Ser?Gly?Ile?Ala?Ser?Leu

195 200 205

Leu?Tyr?Ile?Leu?Arg?Met?Trp?Gln?Pro?Lys?Gly?Lys?Glu?Lys?Gly?Phe

210 215 220

Phe?Gly?Ala?Val?Ala?Lys?Pro?Leu?Pro?Ser?Gly?Lys?Thr?Leu?Asp?Asn

225 230 235 240

Leu?Ala?Tyr?Lys?Thr?Ala?Ile?Trp?Thr?Val?Pro?Ile?Phe?Gly?Leu?Gly

245 250 255

Ile?Ile?Leu?Gly?Ala?Ile?Trp?Ala?Glu?Ala?Ala?Trp?Gly?Arg?Phe?Trp

260 265 270

Gly?Trp?Asp?Pro?Lys?Glu?Thr?Val?Ser?Phe?Ile?Thr?Trp?Val?Leu?Tyr

275 280 285

Ala?Gly?Tyr?Leu?His?Ala?Arg?Ala?Thr?Ala?Gly?Trp?Arg?Asn?Thr?Asn

290 295 300

Ala?Ala?Trp?Ile?Asn?Ile?Leu?Ala?Leu?Val?Thr?Met?Ile?Phe?Asn?Leu

305 310 315 320

Phe?Phe?Ile?Asn?Met?Val?Val?Ser?Gly?Leu?His?Ser?Tyr?Ala?Gly?Leu

325 330 335

Asn

<210>729

<211>326

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(303)

<223>FRXA00388

<400>729

acc?ctg?gat?aac?ctg?gca?tac?aag?acc?gcg?atc?tgg?act?gtc?cca?atc 48

Thr?Leu?Asp?Asn?Leu?Ala?Tyr?Lys?Thr?Ala?Ile?Trp?Thr?Val?Pro?Ile

1 5 10 15

ttc?ggc?ctg?ggc?atc?atc?ttg?ggt?gcc?atc?tgg?gca?gaa?gca?gcc?tgg 96

Phe?Gly?Leu?Gly?Ile?Ile?Leu?Gly?Ala?Ile?Trp?Ala?Glu?Ala?Ala?Trp

20 25 30

ggt?cgt?ttc?tgg?gga?tgg?gat?cct?aag?gaa?aca?gtc?tcc?ttc?atc?acc 144

Gly?Arg?Phe?Trp?Gly?Trp?Asp?Pro?Lys?Glu?Thr?Val?Ser?Phe?Ile?Thr

35 40 45

tgg?gtt?ctc?tac?gct?ggt?tac?ctc?cac?gca?cgt?gca?act?gct?ggt?tgg 192

Trp?Val?Leu?Tyr?Ala?Gly?Tyr?Leu?His?Ala?Arg?Ala?Thr?Ala?Gly?Trp

50 55 60

cgc?aac?acc?aac?gct?gca?tgg?atc?aac?atc?ctg?gcg?ctg?gtc?acg?atg 240

Arg?Asn?Thr?Asn?Ala?Ala?Trp?Ile?Asn?Ile?Leu?Ala?Leu?Val?Thr?Met

65 70 75 80

att?ttt?aat?ctg?ttc?ttc?atc?aac?atg?gtc?gta?tct?ggt?ctg?cac?tct 288

Ile?Phe?Asn?Leu?Phe?Phe?Ile?Asn?Met?Val?Val?Ser?Gly?Leu?His?Ser

85 90 95

tac?gcc?gga?ctg?aac?taagcacttt?tggttggcgg?ggt 326

Tyr?Ala?Gly?Leu?Asn

100

<210>730

<211>101

<212>PRT

＜213〉Corynebacterium glutamicum

<400>730

Thr?Leu?Asp?Asn?Leu?Ala?Tyr?Lys?Thr?Ala?Ile?Trp?Thr?Val?Pro?Ile

1 5 10 15

Phe?Gly?Leu?Gly?Ile?Ile?Leu?Gly?Ala?Ile?Trp?Ala?Gu?Ala?Ala?Trp

20 25 30

Gly?Arg?Phe?Trp?Gly?Trp?Asp?Pro?Lys?Glu?Thr?Val?Ser?Phe?Ile?Thr

35 40 45

Trp?Val?Leu?Tyr?Ala?Gly?Tyr?Leu?His?Ala?Arg?Ala?Thr?Ala?Gly?Trp

50 55 60

Arg?Asn?Thr?Asn?Ala?Ala?Trp?Ile?Asn?Ile?Leu?Ala?Leu?Val?Thr?Met

65 70 75 80

Ile?Phe?Asn?Leu?Phe?Phe?Ile?Asn?Met?Val?Val?Ser?Gly?Leu?His?Ser

85 90 95

Tyr?Ala?Gly?Leu?Asn

100

<210>731

<211>610

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(610)

<223>FRXA00386

<400>731

gaagagtact?tcgaccacga?cgactaacac?cgcaatttaa?aggcttttca?agcctgcccc?60

acatcgaagc?agttttcaca?aagaataagg?ttggaaaatt?atg?ttg?ccc?gtc?aac 115

Met?Leu?Pro?Val?Asn

1 5

caa?acg?tat?gcg?cag?ttc?tca?gac?act?gcc?ttc?gta?tcg?gca?tac?atc 163

Gln?Thr?Tyr?Ala?Gln?Phe?Ser?Asp?Thr?Ala?Phe?Val?Ser?Ala?Tyr?Ile

10 15 20

atc?tac?gtt?ctg?gca?ctc?atc?ctc?tcc?ctc?gtc?tac?tac?gta?aaa?caa 211

Ile?Tyr?Val?Leu?Ala?Leu?Ile?Leu?Ser?Leu?Val?Tyr?Tyr?Val?Lys?Gln

25 30 35

caa?ggc?att?atc?gac?gcc?cgc?cgc?gag?caa?acc?cgc?gtc?agc?gaa?ctc 259

Gln?Gly?Ile?Ile?Asp?Ala?Arg?Arg?Glu?Gln?Thr?Arg?Val?Ser?Glu?Leu

40 45 50

gtt?ggt?gca?ggc?ggc?agc?gct?gat?gtt?gat?act?gac?ctg?cct?gat?gac 307

Val?Gly?Ala?Gly?Gly?Ser?Ala?Asp?Val?Asp?Thr?Asp?Leu?Pro?Asp?Asp

55 60 65

atc?gcc?gac?ggt?gtc?ctc?gcc?gac?gaa?gac?ctt?gca?aaa?cgc?gaa?gaa 355

Ile?Ala?Asp?Gly?Val?Leu?Ala?Asp?Glu?Asp?Leu?Ala?Lys?Arg?Glu?Glu

70 75 80 85

acc?gca?cgc?aaa?cta?gcc?aac?atg?acc?caa?tct?ctc?atg?tgg?ctc?ggc 403

Thr?Ala?Arg?Lys?Leu?Ala?Asn?Met?Thr?Gln?Ser?Leu?Met?Trp?Leu?Gly

90 95 100

gtc?atg?gtg?cac?ctc?gta?tcc?gtc?gtg?atg?cgc?gcg?ctg?tct?gcc?agc 451

Val?Met?Val?His?Leu?Val?Ser?Val?Val?Met?Arg?Ala?Leu?Ser?Ala?Ser

105 110 115

cga?ttc?ccc?ttc?ggc?aac?ctg?tat?gaa?tac?atc?ctc?atg?gtc?acc?ctc 499

Arg?Phe?Pro?Phe?Gly?Asn?Leu?Tyr?Glu?Tyr?Ile?Leu?Met?Val?Thr?Leu

120 125 130

ttc?gcc?atg?atc?gga?gcc?gta?ctc?atc?ctg?cag?cgc?cca?caa?ttc?cgc 547

Phe?Ala?Met?Ile?Gly?Ala?Val?Leu?Ile?Leu?Gln?Arg?Pro?Gln?Phe?Arg

135 140 145

gtg?gta?tgg?cca?tgg?atc?ctc?acc?cca?atg?gct?ggc?act?tgg?ttt?tct 595

Val?Val?Trp?Pro?Trp?Ile?Leu?Thr?Pro?Met?Ala?Gly?Thr?Trp?Phe?Ser

150 155 160 165

acg?gtg?gca?ccc?agc 610

Thr?Val?Ala?Pro?Ser

170

<210>732

<211>170

<212>PRT

＜213〉Corynebacterium glutamicum

<400>732

Met?Leu?Pro?Val?Asn?Gln?Thr?Tyr?Ala?Gln?Phe?Ser?Asp?Thr?Ala?Phe

1 5 10 15

Val?Ser?Ala?Tyr?Ile?Ile?Tyr?Val?Leu?Ala?Leu?Ile?Leu?Ser?Leu?Val

20 25 30

Tyr?Tyr?Val?Lys?Gln?Gln?Gly?Ile?Ile?Asp?Ala?Arg?Arg?Glu?Gln?Thr

35 40 45

Arg?Val?Ser?Glu?Leu?Val?Gly?Ala?Gly?Gly?Ser?Ala?Asp?Val?Asp?Thr

50 55 60

Asp?Leu?Pro?Asp?Asp?Ile?Ala?Asp?Gly?Val?Leu?Ala?Asp?Glu?Asp?Leu

65 70 75 80

Ala?Lys?Arg?Glu?Glu?Thr?Ala?Arg?Lys?Leu?Ala?Asn?Met?Thr?Gln?Ser

85 90 95

Leu?Met?Trp?Leu?Gly?Val?Met?Val?His?Leu?Val?Ser?Val?Val?Met?Arg

100 105 110

Ala?Leu?Ser?Ala?Ser?Arg?Phe?Pro?Phe?Gly?Asn?Leu?Tyr?Glu?Tyr?Ile

115 120 125

Leu?Met?Val?Thr?Leu?Phe?Ala?Met?Ile?Gly?Ala?Val?Leu?Ile?Leu?Gln

130 135 140

Arg?Pro?Gln?Phe?Arg?Val?Val?Trp?Pro?Trp?Ile?Leu?Thr?Pro?Met?Ala

145 150 155 160

Gly?Thr?Trp?Phe?Ser?Thr?Val?Ala?Pro?Ser

165 170

<210>733

<211>1095

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1072)

<223>RXA00945

<400>733

tcacagtacc?acccacaagc?cacaaggagg?gtatggaggt?gggcgtctaa?agccaaattt?60

ttcccggtgt?ttgaggcgat?tgcaccgtac?actaatgtgc?atg?ctt?gaa?cgc?ctc 115

Met?Leu?Glu?Arg?Leu

1 5

aaa?cgc?cta?gat?ccg?ctc?att?gtc?ctc?att?gtg?ctg?gct?gtc?att?gtg 163

Lys?Arg?Leu?Asp?Pro?Leu?Ile?Val?Leu?Ile?Val?Leu?Ala?Val?Ile?Val

10 15 20

gcg?atc?atc?att?cca?gtt?cgc?ggg?gtt?gct?gcg?gat?tgg?ttt?gat?gtc 211

Ala?Ile?Ile?Ile?Pro?Val?Arg?Gly?Val?Ala?Ala?Asp?Trp?Phe?Asp?Val

25 30 35

gcc?gtc?aag?att?gcc?att?gcg?ctg?ctg?ttt?ttt?ctt?tat?ggt?gcc?cgc 259

Ala?Val?Lys?Ile?Ala?Ile?Ala?Leu?Leu?Phe?Phe?Leu?Tyr?Gly?Ala?Arg

40 45 50

cta?tcc?acc?caa?gag?gcg?ctg?aat?ggt?ctg?aag?cac?tgg?agg?ctt?cac 307

Leu?Ser?Thr?Gln?Glu?Ala?Leu?Asn?Gly?Leu?Lys?His?Trp?Arg?Leu?His

55 60 65

ctg?act?att?ttg?gcg?atc?act?ttc?gga?ata?ttc?cca?ctt?atc?ggc?att 355

Leu?Thr?Ile?Leu?Ala?Ile?Thr?Phe?Gly?Ile?Phe?Pro?Leu?Ile?Gly?Ile

70 75 80 85

ggg?ctc?gag?ccg?atg?act?gca?ttt?gtg?tcg?gaa?gat?att?tat?cgg?gga 403

Gly?Leu?Glu?Pro?Met?Thr?Ala?Phe?Val?Ser?Glu?Asp?Ile?Tyr?Arg?Gly

90 95 100

att?ttg?ttc?ctc?acg?ctc?gtt?ccg?tcc?acc?gtg?cag?tca?tcg?gtg?gcg 451

Ile?Leu?Phe?Leu?Thr?Leu?Val?Pro?Ser?Thr?Val?Gln?Ser?Ser?Val?Ala

105 110 115

ttt?acc?tcg?atc?gct?aaa?ggc?aac?gta?gct?ggt?gcg?att?gtg?tcg?gca 499

Phe?Thr?Ser?Ile?Ala?Lys?Gly?Asn?Val?Ala?Gly?Ala?Ile?Val?Ser?Ala

120 125 130

tcg?ctc?tcc?aac?ctt?gcg?ggt?gtt?ttc?ctc?act?ccg?ctg?ctg?gtc?atg 547

Ser?Leu?Ser?Asn?Leu?Ala?Gly?Val?Phe?Leu?Thr?Pro?Leu?Leu?Val?Met

135 140 145

ctc?atc?atg?tct?gcg?ggc?ggg?gga?gtt?cac?gtg?gat?tcc?cag?gtc?ttc 595

Leu?Ile?Met?Ser?Ala?Gly?Gly?Gly?Val?His?Val?Asp?Ser?Gln?Val?Phe

150 155 160 165

ctc?gac?att?gcg?att?cag?ctt?ctg?ctg?ccg?ttc?atc?ctc?ggc?cag?gta 643

Leu?Asp?Ile?Ala?Ile?Gln?Leu?Leu?Leu?Pro?Phe?Ile?Leu?Gly?Gln?Val

170 175 180

tgt?agg?cgt?tgg?gtg?aag?aat?ttt?gcg?gcc?aac?aaa?gca?aca?aaa?atc 691

Cys?Arg?Arg?Trp?Val?Lys?Asn?Phe?Ala?Ala?Asn?Lys?Ala?Thr?Lys?Ile

185 190 195

gtg?gac?cgc?ggc?tcg?atc?gcg?atg?gtc?gtg?tac?tcc?gcg?ttt?tct?gcc 739

Val?Asp?Arg?Gly?Ser?Ile?Ala?Met?Val?Val?Tyr?Ser?Ala?Phe?Ser?Ala

200 205 210

ggc?atg?gtg?gct?ggc?att?tgg?tcc?act?gtg?agc?gtt?cta?gag?att?atc 787

Gly?Met?Val?Ala?Gly?Ile?Trp?Ser?Thr?Val?Ser?Val?Leu?Glu?Ile?Ile

215 220 225

tac?ctc?att?gtt?ttc?gct?att?ctg?ctg?gtg?atg?gcc?atg?ctg?tgg?ttc 835

Tyr?Leu?Ile?Val?Phe?Ala?Ile?Leu?Leu?Val?Met?Ala?Met?Leu?Trp?Phe

230 235 240 245

acg?ctg?ttc?atg?gct?aca?cgc?ctt?gga?ttt?aac?cgg?gca?gat?tcc?atc 883

Thr?Leu?Phe?Met?Ala?Thr?Arg?Leu?Gly?Phe?Asn?Arg?Ala?Asp?Ser?Ile

250 255 260

gct?att?cag?ttc?tgc?gga?acc?aag?aaa?tcc?ctg?gcc?aca?ggc?ctc?cca 931

Ala?Ile?Gln?Phe?Cys?Gly?Thr?Lys?Lys?Ser?Leu?Ala?Thr?Gly?Leu?Pro

265 270 275

atg?gcg?gca?gtc?atc?ttc?ggt?ggc?gcc?aat?atc?ggc?ctg?ctc?atc?ttg 979

Met?Ala?Ala?Val?Ile?Phe?Gly?Gly?Ala?Asn?Ile?Gly?Leu?Leu?Ile?Leu

280 285 290

ccg?ttg?atg?atc?ttc?cac?caa?gtc?cag?ctg?atg?att?tgt?gca?tgg?ctt 1027

Pro?Leu?Met?Ile?Phe?His?Gln?Val?Gln?Leu?Met?Ile?Cys?Ala?Trp?Leu

295 300 305

gca?gct?cgt?tat?ggt?cgt?gat?gcg?cag?gaa?cag?aaa?gcc?aac?gcc 1072

Ala?Ala?Arg?Tyr?Gly?Arg?Asp?Ala?Gln?Glu?Gln?Lys?Ala?Asn?Ala

310 315 320

taaaagtcct?cagtagctag?cca 1095

<210>734

<211>324

<212>PRT

＜213〉Corynebacterium glutamicum

<400>734

Met?Leu?Glu?Arg?Leu?Lys?Arg?Leu?Asp?Pro?Leu?Ile?Val?Leu?Ile?Val

1 5 10 15

Leu?Ala?Val?Ile?Val?Ala?Ile?Ile?Ile?Pro?Val?Arg?Gly?Val?Ala?Ala

20 25 30

Asp?Trp?Phe?Asp?Val?Ala?Val?Lys?Ile?Ala?Ile?Ala?Leu?Leu?Phe?Phe

35 40 45

Leu?Tyr?Gly?Ala?Arg?Leu?Ser?Thr?Gln?Glu?Ala?Leu?Asn?Gly?Leu?Lys

50 55 60

His?Trp?Arg?Leu?His?Leu?Thr?Ile?Leu?Ala?Ile?Thr?Phe?Gly?Ile?Phe

65 70 75 80

Pro?Leu?Ile?Gly?Ile?Gly?Leu?Glu?Pro?Met?Thr?Ala?Phe?Val?Ser?Glu

85 90 95

Asp?Ile?Tyr?Arg?Gly?Ile?Leu?Phe?Leu?Thr?Leu?Val?Pro?Ser?Thr?Val

100 105 110

Gln?Ser?Ser?Val?Ala?Phe?Thr?Ser?Ile?Ala?Lys?Gly?Asn?Val?Ala?Gly

115 120 125

Ala?Ile?Val?Ser?Ala?Ser?Leu?Ser?Asn?Leu?Ala?Gly?Val?Phe?Leu?Thr

130 135 140

Pro?Leu?Leu?Val?Met?Leu?Ile?Met?Ser?Ala?Gly?Gly?Gly?Val?His?Val

145 150 155 160

Asp?Ser?Gln?Val?Phe?Leu?Asp?Ile?Ala?Ile?Gln?Leu?Leu?Leu?Pro?Phe

165 170 175

Ile?Leu?Gly?Gln?Val?Cys?Arg?Arg?Trp?Val?Lys?Asn?Phe?Ala?Ala?Asn

180 185 190

Lys?Ala?Thr?Lys?Ile?Val?Asp?Arg?Gly?Ser?Ile?Ala?Met?Val?Val?Tyr

195 200 205

Ser?Ala?Phe?Ser?Ala?Gly?Met?Val?Ala?Gly?Ile?Trp?Ser?Thr?Val?Ser

210 215 220

Val?Leu?Glu?Ile?Ile?Tyr?Leu?Ile?Val?Phe?Ala?Ile?Leu?Leu?Val?Met

225 230 235 240

Ala?Met?Leu?Trp?Phe?Thr?Leu?Phe?Met?Ala?Thr?Arg?Leu?Gly?Phe?Asn

245 250 255

Arg?Ala?Asp?Ser?Ile?Ala?Ile?Gln?Phe?Cys?Gly?Thr?Lys?Lys?Ser?Leu

260 265 270

Ala?Thr?Gly?Leu?Pro?Met?Ala?Ala?Val?Ile?Phe?Gly?Gly?Ala?Asn?Ile

275 280 285

Gly?Leu?Leu?Ile?Leu?Pro?Leu?Met?Ile?Phe?His?Gln?Val?Gln?Leu?Met

290 295 300

Ile?Cys?Ala?Trp?Leu?Ala?Ala?Arg?Tyr?Gly?Arg?Asp?Ala?Gln?Glu?Gln

305 310 315 320

Lys?Ala?Asn?Ala

<210>735

<211>1281

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1258)

<223>RXN02556

<400>735

tgccatcata?ttaaggccaa?attgcttgga?tcctgggatt?tatttaatta?gattaaatcc?60

gtagaaatta?gcccatgaag?catggaaagg?cgaaaacccc?ttg?atc?gtt?tcc?acc 115

Leu?Ile?Val?Ser?Thr

1 5

cag?ccc?att?act?gat?cgc?agc?gca?ctc?tcg?gca?gaa?cac?gca?gag?gtg 163

Gln?Pro?Ile?Thr?Asp?Arg?Ser?Ala?Leu?Ser?Ala?Glu?His?Ala?Glu?Val

10 15 20

atc?aaa?gca?acg?ctt?cct?ctc?gtg?ggc?ggc?aag?att?aat?gag?atc?acg 211

Ile?Lys?Ala?Thr?Leu?Pro?Leu?Val?Gly?Gly?Lys?Ile?Asn?Glu?Ile?Thr

25 30 35

ccg?gtt?ttc?tac?aac?aag?atg?ttt?gcg?gct?cac?cca?gaa?ttg?atc?gct 259

Pro?Val?Phe?Tyr?Asn?Lys?Met?Phe?Ala?Ala?His?Pro?Glu?Leu?Ile?Ala

40 45 50

aac?acc?ttc?aac?cgt?ggc?aat?cag?aag?caa?ggc?gat?cag?cag?aag?gcg 307

Asn?Thr?Phe?Asn?Arg?Gly?Asn?Gln?Lys?Gln?Gly?Asp?Gln?Gln?Lys?Ala

55 60 65

ctg?gcg?gct?tcg?att?gca?acg?ttt?gcc?acc?atg?ctc?gtt?act?cct?gat 355

Leu?Ala?Ala?Ser?Ile?Ala?Thr?Phe?Ala?Thr?Met?Leu?Val?Thr?Pro?Asp

70 75 80 85

gct?cct?gac?cca?gtt?cag?ctg?ctg?tcc?cgc?att?ggc?cac?aag?cac?gtg 403

Ala?Pro?Asp?Pro?Val?Gln?Leu?Leu?Ser?Arg?Ile?Gly?His?Lys?His?Val

90 95 100

tcc?ctc?ggc?att?act?gct?gat?cag?tac?gac?att?gtt?cac?gag?cac?ctg 451

Ser?Leu?Gly?Ile?Thr?Ala?Asp?Gln?Tyr?Asp?Ile?Val?His?Glu?His?Leu

105 110 115

ttc?gcc?gca?atc?gtt?gag?gtt?ttg?gga?gcg?gaa?act?gtc?acc?gca?cct 499

Phe?Ala?Ala?Ile?Val?Glu?Val?Leu?Gly?Ala?Glu?Thr?Val?Thr?Ala?Pro

120 125 130

gtc?gct?gaa?gcc?tgg?gat?gct?gtc?tac?tgg?atc?atg?gca?aat?gtg?ctg 547

Val?Ala?Glu?Ala?Trp?Asp?Ala?Val?Tyr?Trp?Ile?Met?Ala?Asn?Val?Leu

135 140 145

atc?ggt?ttt?gag?aac?aac?ctt?tat?gct?tcc?aac?gat?ctg?gag?cct?ggc 595

Ile?Gly?Phe?Glu?Asn?Asn?Leu?Tyr?Ala?Ser?Asn?Asp?Leu?Glu?Pro?Gly

150 155 160 165

gac?gtc?ttc?cgc?gaa?gtc?acc?gtg?acc?gcg?aag?aag?cag?ctc?agc?gca 643

Asp?Val?Phe?Arg?Glu?Val?Thr?Val?Thr?Ala?Lys?Lys?Gln?Leu?Ser?Ala

170 175 180

acc?gtc?tgg?gaa?tac?acc?ctg?gca?ggt?gag?ctg?gtt?gcc?cca?gag?cca 691

Thr?Val?Trp?Glu?Tyr?Thr?Leu?Ala?Gly?Glu?Leu?Val?Ala?Pro?Glu?Pro

185 190 195

ggt?cag?tac?acc?tcc?atc?gga?gta?gtg?ctt?gac?gac?ggc?gcc?cgc?cag 739

Gly?Gln?Tyr?Thr?Ser?Ile?Gly?Val?Val?Leu?Asp?Asp?Gly?Ala?Arg?Gln

200 205 210

ctg?cgc?cag?tac?agc?ttg?ctc?ggc?ggc?tcc?gac?acc?gag?tac?cgc?att 787

Leu?Arg?Gln?Tyr?Ser?Leu?Leu?Gly?Gly?Ser?Asp?Thr?Glu?Tyr?Arg?Ile

215 220 225

gcg?gtt?gag?gat?aac?ggc?gag?gtt?tct?gga?ttc?ctg?cgt?gat?cgc?gta 835

Ala?Val?Glu?Asp?Asn?Gly?Glu?Val?Ser?Gly?Phe?Leu?Arg?Asp?Arg?Val

230 235 240 245

tcc?gtt?ggt?gac?aag?att?gaa?gcc?acc?atc?gcg?gcc?ggc?gac?ctg?gtt 883

Ser?Val?Gly?Asp?Lys?Ile?Glu?Ala?Thr?Ile?Ala?Ala?Gly?Asp?Leu?Val

250 255 260

ctt?aac?aag?gac?acc?aat?cca?gtt?gtg?ctg?att?tcc?cag?ggc?atc?ggc 931

Leu?Asn?Lys?Asp?Thr?Asn?Pro?Val?Val?Leu?Ile?Ser?Gln?Gly?Ile?Gly

265 270 275

tcc?acc?cca?atg?gtg?ggc?atg?ctc?gca?ggt?atg?aac?cct?gaa?cgt?gac 979

Ser?Thr?Pro?Met?Val?Gly?Met?Leu?Ala?Gly?Met?Asn?Pro?Glu?Arg?Asp

280 285 290

gtt?gtg?gtt?ttg?cat?gct?gac?cag?gcc?gag?tcc?acc?tac?gcg?cag?gtg 1027

Val?Val?Val?Leu?His?Ala?Asp?Gln?Ala?Glu?Ser?Thr?Tyr?Ala?Gln?Val

295 300 305

gag?gaa?gtg?cag?ggg?ctc?gtc?gaa?aag?ctc?cct?aag?gct?gcg?ttt?gaa 1075

Glu?Glu?Val?Gln?Gly?Leu?Val?Glu?Lys?Leu?Pro?Lys?Ala?Ala?Phe?Glu

310 315 320 325

atc?ttc?tac?cgc?gac?aac?gac?cag?tgg?ctc?gag?gtc?gct?ggc?cgc?att 1123

Ile?Phe?Tyr?Arg?Asp?Asn?Asp?Gln?Trp?Leu?Glu?Val?Ala?Gly?Arg?Ile

330 335 340

cca?tca?ggt?gcg?tcc?gtg?tac?ctg?tgc?ggt?ggc?gtg?gaa?ttc?ttg?aag 1171

Pro?Ser?Gly?Ala?Set?Val?Tyr?Leu?Cys?Gly?Gly?Val?Glu?Phe?Leu?Lys

345 350 355

aac?gtg?cgt?gag?cag?atc?gag?gcg?ctc?gat?gag?cag?cct?cgc?gac?gta 1219

Asn?Val?Arg?Glu?Gln?Ile?Glu?Ala?Leu?Asp?Glu?Gln?Pro?Arg?Asp?Val

360 365 370

aac?ttc?gag?ctc?ttc?gca?cca?aac?gac?tgg?ctg?att?tcc?taagcccaca 1268

Asn?Phe?Glu?Leu?Phe?Ala?Pro?Asn?Asp?Trp?Leu?Ile?Ser

375 380 385

ccccagaact?tcc 1281

<210>736

<211>386

<212>PRT

＜213〉Corynebacterium glutamicum

<400>?736

Leu?Ile?Val?Ser?Thr?Gln?Pro?Ile?Thr?Asp?Arg?Ser?Ala?Leu?Ser?Ala

1 5 10 15

Glu?His?Ala?Glu?Val?Ile?Lys?Ala?Thr?Leu?Pro?Leu?Val?Gly?Gly?Lys

20 25 30

Ile?Asn?Glu?Ile?Thr?Pro?Val?Phe?Tyr?Asn?Lys?Met?Phe?Ala?Ala?His

35 40 45

Pro?Glu?Leu?Ile?Ala?Asn?Thr?Phe?Asn?Arg?Gly?Asn?Gln?Lys?Gln?Gly

50 55 60

Asp?Gln?Gln?Lys?Ala?Leu?Ala?Ala?Ser?Ile?Ala?Thr?Phe?Ala?Thr?Met

65 70 75 80

Leu?Val?Thr?Pro?Asp?Ala?Pro?Asp?Pro?Val?Gln?Leu?Leu?Ser?Arg?Ile

85 90 95

Gly?His?Lys?His?Val?Ser?Leu?Gly?Ile?Thr?Ala?Asp?Gln?Tyr?Asp?Ile

100 105 110

Val?His?Glu?His?Leu?Phe?Ala?Ala?Ile?Val?Glu?Val?Leu?Gly?Ala?Glu

115 120 125

Thr?Val?Thr?Ala?Pro?Val?Ala?Glu?Ala?Trp?Asp?Ala?Val?Tyr?Trp?Ile

130 135 140

Met?Ala?Asn?Val?Leu?Ile?Gly?Phe?Glu?Asn?Asn?Leu?Tyr?Ala?Ser?Asn

145 150 155 160

Asp?Leu?Glu?Pro?Gly?Asp?Val?Phe?Arg?Glu?Val?Thr?Val?Thr?Ala?Lys

165 170 175

Lys?Gln?Leu?Ser?Ala?Thr?Val?Trp?Glu?Tyr?Thr?Leu?Ala?Gly?Glu?Leu

180 185 190

Val?Ala?Pro?Glu?Pro?Gly?Gln?Tyr?Thr?Ser?Ile?Gly?Val?Val?Leu?Asp

195 200 205

Asp?Gly?Ala?Arg?Gln?Leu?Arg?Gln?Tyr?Ser?Leu?Leu?Gly?Gly?Ser?Asp

210 215 220

Thr?Glu?Tyr?Arg?Ile?Ala?Val?Glu?Asp?Asn?Gly?Glu?Val?Ser?Gly?Phe

225 230 235 240

Leu?Arg?Asp?Arg?Val?Ser?Val?Gly?Asp?Lys?Ile?Glu?Ala?Thr?Ile?Ala

245 250 255

Ala?Gly?Asp?Leu?Val?Leu?Asn?Lys?Asp?Thr?Asn?Pro?Val?Val?Leu?Ile

260 265 270

Ser?Gln?Gly?Ile?Gly?Ser?Thr?Pro?Met?Val?Gly?Met?Leu?Ala?Gly?Met

275 280 285

Asn?Pro?Glu?Arg?Asp?Val?Val?Val?Leu?His?Ala?Asp?Gln?Ala?Glu?Ser

290 295 300

Thr?Tyr?Ala?Gln?Val?Glu?Glu?Val?Gln?Gly?Leu?Val?Glu?Lys?Leu?Pro

305 310 315 320

Lys?Ala?Ala?Phe?Glu?Ile?Phe?Tyr?Arg?Asp?Asn?Asp?Gln?Trp?Leu?Glu

325 330 335

Val?Ala?Gly?Arg?Ile?Pro?Ser?Gly?Ala?Ser?Val?Tyr?Leu?Cys?Gly?Gly

340 345 350

Val?Glu?Phe?Leu?Lys?Asn?Val?Arg?Glu?Gln?Ile?Glu?Ala?Leu?Asp?Glu

355 360 365

Gln?Pro?Arg?Asp?Val?Asn?Phe?Glu?Leu?Phe?Ala?Pro?Asn?Asp?Trp?Leu

370 375 380

Ile?Ser

385

<210>737

<211>1281

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1258)

<223>FRXA02556

<400>737

tgccatcata?ttaaggccaa?attgcttgga?tcctgggatt?tatttaatta?gattaaatcc?60

gtagaaatta?gcccatgaag?catggaaagg?cgaaaacccc?ttg?atc?gtt?tcc?acc 115

Leu?Ile?Val?Ser?Thr

1 5

cag?ccc?att?act?gat?cgc?agc?gca?ctc?tcg?gca?gaa?cac?gca?gag?gtg 163

Gln?Pro?Ile?Thr?Asp?Arg?Ser?Ala?Leu?Ser?Ala?Glu?His?Ala?Glu?Val

10 15 20

atc?aaa?gca?acg?ctt?cct?ctc?gtg?ggc?ggc?aag?att?aat?gag?atc?acg 211

Ile?Lys?Ala?Thr?Leu?Pro?Leu?Val?Gly?Gly?Lys?Ile?Asn?Glu?Ile?Thr

25 30 35

ccg?gtt?ttc?tac?aac?aag?atg?ttt?gcg?gct?cac?cca?gaa?ttg?atc?gct 259

Pro?Val?Phe?Tyr?Asn?Lys?Met?Phe?Ala?Ala?His?Pro?Glu?Leu?Ile?Ala

40 45 50

aac?acc?ttc?aac?ggt?ggc?aat?cag?aag?caa?ggc?gat?cag?cag?aag?gcg 307

Asn?Thr?Phe?Asn?Gly?Gly?Asn?Gln?Lys?Gln?Gly?Asp?Gln?Gln?Lys?Ala

55 60 65

ctg?gcg?gct?tcg?att?gca?acg?ttt?gcc?acc?atg?ctc?gtt?act?cct?gat 355

Leu?Ala?Ala?Ser?Ile?Ala?Thr?Phe?Ala?Thr?Met?Leu?Val?Thr?Pro?Asp

70 75 80 85

gct?cct?gac?cca?gtt?cag?ctg?ctg?tcc?cgc?att?ggc?cac?aag?cac?gtg 403

Ala?Pro?Asp?Pro?Val?Gln?Leu?Leu?Ser?Arg?Ile?Gly?His?Lys?His?Val

90 95 100

tcc?ctc?ggc?att?act?gct?gat?cag?tac?gac?att?gtt?cac?gag?cac?ctg 451

Ser?Leu?Gly?Ile?Thr?Ala?Asp?Gln?Tyr?Asp?Ile?Val?His?Glu?His?Leu

105 110 115

ttc?gcc?gca?atc?gtt?gag?gtt?ttg?gga?gcg?gaa?act?gtc?acc?gca?cct 499

Phe?Ala?Ala?Ile?Val?Glu?Val?Leu?Gly?Ala?Glu?Thr?Val?Thr?Ala?Pro

120 125 130

gtc?gct?gaa?gcc?tgg?gat?gct?gtc?tac?tgg?atc?atg?gca?aat?gtg?ctg 547

Val?Ala?Glu?Ala?Trp?Asp?Ala?Val?Tyr?Trp?Ile?Met?Ala?Asn?Val?Leu

135 140 145

atc?ggt?ttt?gag?aac?aac?ctt?tat?gct?tcc?aac?gat?ctg?gag?cct?ggc 595

Ile?Gly?Phe?Glu?Asn?Asn?Leu?Tyr?Ala?Ser?Asn?Asp?Leu?Glu?Pro?Gly

150 155 160 165

gac?gtc?ttc?cgc?gaa?gtc?acc?gtg?acc?gcg?aag?aag?cag?ctc?agc?gca 643

Asp?Val?Phe?Arg?Glu?Val?Thr?Val?Thr?Ala?Lys?Lys?Gln?Leu?Ser?Ala

170 175 180

acc?gtc?tgg?gaa?tac?acc?ctg?gca?ggt?gag?ctg?gtt?gcc?cca?gag?cca 691

Thr?Val?Trp?Glu?Tyr?Thr?Leu?Ala?Gly?Glu?Leu?Val?Ala?Pro?Glu?Pro

185 190 195

ggt?cag?tac?acc?tcc?atc?gga?gta?gtg?ctt?gac?gac?ggc?gcc?cgc?cag 739

Gly?Gln?Tyr?Thr?Ser?Ile?Gly?Val?Val?Leu?Asp?Asp?Gly?Ala?Arg?Gln

200 205 210

ctg?cgc?cag?tac?agc?ttg?ctc?ggc?ggc?tcc?gac?acc?gag?tac?cgc?att 787

Leu?Arg?Gln?Tyr?Ser?Leu?Leu?Gly?Gly?Ser?Asp?Thr?Glu?Tyr?Arg?Ile

215 220 225

gcg?gtt?gag?gat?aac?ggc?gag?gtt?tct?gga?ttc?ctg?cgt?gat?cgc?gta 835

Ala?Val?Glu?Asp?Asn?Gly?Glu?Val?Ser?Gly?Phe?Leu?Arg?Asp?Arg?Val

230 235 240 245

tcc?gtt?ggt?gac?aag?att?gaa?gcc?acc?atc?gcg?gcc?ggc?gac?ctg?gtt 883

Ser?Val?Gly?Asp?Lys?Ile?Glu?Ala?Thr?Ile?Ala?Ala?Gly?Asp?Leu?Val

250 255 260

ctt?aac?aag?gac?acc?aat?cca?gtt?gtg?ctg?att?tcc?cag?ggc?atc?ggc 931

Leu?Asn?Lys?Asp?Thr?Asn?Pro?Val?Val?Leu?Ile?Ser?Gln?Gly?Ile?Gly

265 270 275

tcc?acc?cca?atg?gtg?ggc?atg?ctc?gca?ggt?atg?aac?cct?gaa?cgt?gac 979

Ser?Thr?Pro?Met?Val?Gly?Met?Leu?Ala?Gly?Met?Asn?Pro?Glu?Arg?Asp

280 285 290

gtt?gtg?gtt?ttg?cat?gct?gac?cag?gcc?gag?tcc?acc?tac?gcg?cag?gtg 1027

Val?Val?Val?Leu?His?Ala?Asp?Gln?Ala?Glu?Ser?Thr?Tyr?Ala?Gln?Val

295 300 305

gag?gaa?gtg?cag?ggg?ctc?gtc?gaa?aag?ctc?cct?aag?gct?gcg?ttt?gaa 1075

Glu?Glu?Val?Gln?Gly?Leu?Val?Glu?Lys?Leu?Pro?Lys?Ala?Ala?Phe?Glu

310 315 320 325

atc?ttc?tac?cgc?gac?aac?gac?cag?tgg?ctc?gag?gtc?gct?ggc?cgc?att 1123

Ile?Phe?Tyr?Arg?Asp?Asn?Asp?Gln?Trp?Leu?Glu?Val?Ala?Gly?Arg?Ile

330 335 340

cca?tca?ggt?gcg?tcc?gtg?tac?ctg?tgc?ggt?ggc?gtg?gaa?ttc?ttg?aag 1171

Pro?Ser?Gly?Ala?Ser?Val?Tyr?Leu?Cys?Gly?Gly?Val?Glu?Phe?Leu?Lys

345 350 355

aac?gtg?cgt?gag?cag?atc?gag?gcg?ctc?gat?gag?cag?cct?cgc?gac?gta 1219

Asn?Val?Arg?Glu?Gln?Ile?Glu?Ala?Leu?Asp?Glu?Gln?Pro?Arg?Asp?Val

360 365 370

aac?ttc?gag?ctc?ttc?gca?cca?aac?gac?tgg?ctg?att?tcc?taagcccaca 1268

Asn?Phe?Glu?Leu?Phe?Ala?Pro?Asn?Asp?Trp?Leu?Ile?Ser

375 380 385

ccccagaact?tcc 1281

<210>738

<211>386

<212>PRT

＜213〉Corynebacterium glutamicum

<400>738

Leu?Ile?Val?Ser?Thr?Gln?Pro?Ile?Thr?Asp?Arg?Ser?Ala?Leu?Ser?Ala

1 5 10 15

Glu?His?Ala?Glu?Val?Ile?Lys?Ala?Thr?Leu?Pro?Leu?Val?Gly?Gly?Lys

20 25 30

Ile?Asn?Glu?Ile?Thr?Pro?Val?Phe?Tyr?Asn?Lys?Met?Phe?Ala?Ala?His

35 40 45

Pro?Glu?Leu?Ile?Ala?Asn?Thr?Phe?Asn?Gly?Gly?Asn?Gln?Lys?Gln?Gly

50 55 60

Asp?Gln?Gln?Lys?Ala?Leu?Ala?Ala?Ser?Ile?Ala?Thr?Phe?Ala?Thr?Met

65 70 75 80

Leu?Val?Thr?Pro?Asp?Ala?Pro?Asp?Pro?Val?Gln?Leu?Leu?Ser?Arg?Ile

85 90 95

Gly?His?Lys?His?Val?Ser?Leu?Gly?Ile?Thr?Ala?Asp?Gln?Tyr?Asp?Ile

100 105 110

Val?His?Glu?His?Leu?Phe?Ala?Ala?Ile?Val?Glu?Val?Leu?Gly?Ala?Glu

115 120 125

Thr?Val?Thr?Ala?Pro?Val?Ala?Glu?Ala?Trp?Asp?Ala?Val?Tyr?Trp?Ile

130 135 140

Met?Ala?Asn?Val?Leu?Ile?Gly?Phe?Glu?Asn?Asn?Leu?Tyr?Ala?Ser?Asn

145 150 155 160

Asp?Leu?Glu?Pro?Gly?Asp?Val?Phe?Arg?Glu?Val?Thr?Val?Thr?Ala?Lys

165 170 175

Lys?Gln?Leu?Ser?Ala?Thr?Val?Trp?Glu?Tyr?Thr?Leu?Ala?Gly?Glu?Leu

180 185 190

Val?Ala?Pro?Glu?Pro?Gly?Gln?Tyr?Thr?Ser?Ile?Gly?Val?Val?Leu?Asp

195 200 205

Asp?Gly?Ala?Arg?Gln?Leu?Arg?Gln?Tyr?Ser?Leu?Leu?Gly?Gly?Ser?Asp

210 215 220

Thr?Glu?Tyr?Arg?Ile?Ala?Val?Glu?Asp?Asn?Gly?Glu?Val?Ser?Gly?Phe

225 230 235 240

Leu?Arg?Asp?Arg?Val?Ser?Val?Gly?Asp?Lys?Ile?Glu?Ala?Thr?Ile?Ala

245 250 255

Ala?Gly?Asp?Leu?Val?Leu?Asn?Lys?Asp?Thr?Asn?Pro?Val?Val?Leu?Ile

260 265 270

Ser?Gln?Gly?Ile?Gly?Ser?Thr?Pro?Met?Val?Gly?Met?Leu?Ala?Gly?Met

275 280 285

Asn?Pro?Glu?Arg?Asp?Val?Val?Val?Leu?His?Ala?Asp?Gln?Ala?Glu?Ser

290 295 300

Thr?Tyr?Ala?Gln?Val?Glu?Glu?Val?Gln?Gly?Leu?Val?Glu?Lys?Leu?Pro

305 310 315 320

Lys?Ala?Ala?Phe?Glu?Ile?Phe?Tyr?Arg?Asp?Asn?Asp?Gln?Trp?Leu?Glu

325 330 335

Val?Ala?Gly?Arg?Ile?Pro?Ser?Gly?Ala?Ser?Val?Tyr?Leu?Cys?Gly?Gly

340 345 350

Val?Glu?Phe?Leu?Lys?Asn?Val?Arg?Glu?Gln?Ile?Glu?Ala?Leu?Asp?Glu

355 360 365

Gln?Pro?Arg?Asp?Val?Asn?Phe?Glu?Leu?Phe?Ala?Pro?Asn?Asp?Trp?Leu

370 375 380

Ile?Ser

385

<210>739

<211>1200

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..?(1177)

<223>RXA01392

<400>739

gtctgcaatc?accccgaaca?tttgttcaat?cgttgatttt?cattccactt?cgtaatattg?60

ttgacatatc?atctaaattt?ccaagagagg?acaccacaca?gtg?gct?aac?acg?tca 115

Val?Ala?Asn?Thr?Ser

1 5

tcc?gat?tgg?gca?ggc?gcc?cca?caa?aat?gca?tca?gca?gac?ggc?gag?ttc 163

Ser?Asp?Trp?Ala?Gly?Ala?Pro?Gln?Asn?Ala?Ser?Ala?Asp?Gly?Glu?Phe

10 15 20

gtt?cgc?gat?acc?aac?tac?atc?gat?gac?cgc?atc?gtc?gca?gac?gtt?cca 211

Val?Arg?Asp?Thr?Asn?Tyr?Ile?Asp?Asp?Arg?Ile?Val?Ala?Asp?Val?Pro

25 30 35

gcg?gga?tcc?gaa?cca?att?gct?cag?gaa?gat?ggc?act?ttc?cat?tgg?cct 259

Ala?Gly?Ser?Glu?Pro?Ile?Ala?Gln?Glu?Asp?Gly?Thr?Phe?His?Trp?Pro

40 45 50

gtc?gag?gct?ggt?cgc?tac?cgt?tta?gtc?gct?gcc?cgc?gca?tgt?cca?tgg 307

Val?Glu?Ala?Gly?Arg?Tyr?Arg?Leu?Val?Ala?Ala?Arg?Ala?Cys?Pro?Trp

55 60 65

gca?cac?cgc?act?gtt?atc?acc?cgt?cgt?ctt?ctc?ggc?ctg?gag?aac?gtg 355

Ala?His?Arg?Thr?Val?Ile?Thr?Arg?Arg?Leu?Leu?Gly?Leu?Glu?Asn?Val

70 75 80 85

atc?tcg?ctt?ggt?ctg?acc?ggc?ccg?act?cac?gac?gtt?cgt?tcc?tgg?act 403

Ile?Ser?Leu?Gly?Leu?Thr?Gly?Pro?Thr?His?Asp?Val?Arg?Ser?Trp?Thr

90 95 100

ttc?gat?tta?gat?cca?aac?cat?ctt?gat?ccc?gtg?ctg?cag?att?cct?cgt 451

Phe?Asp?Leu?Asp?Pro?Asn?His?Leu?Asp?Pro?Val?Leu?Gln?Ile?Pro?Arg

105 110 115

cta?cag?gac?gcg?tat?ttc?aac?cgc?ttc?ccc?gat?tac?ccg?cgc?ggc?att 499

Leu?Gln?Asp?Ala?Tyr?Phe?Asn?Arg?Phe?Pro?Asp?Tyr?Pro?Arg?Gly?Ile

120 125 130

act?gtc?cca?gcg?ctc?gtg?gag?gaa?tcg?tct?aag?aag?gtc?gtc?acc?aac 547

Thr?Val?Pro?Ala?Leu?Val?Glu?Glu?Ser?Ser?Lys?Lys?Val?Val?Thr?Asn

135 140 145

gat?tac?cct?tcc?atc?acc?atc?gat?ttc?aat?ctt?gag?tgg?aag?cag?ttc 595

Asp?Tyr?Pro?Ser?Ile?Thr?Ile?Asp?Phe?Asn?Leu?Glu?Trp?Lys?Gln?Phe

150 155 160 165

cac?cgt?gag?ggt?gcg?cct?aac?ctc?tac?ccc?gcg?gag?ctg?cgc?gag?gag 643

His?Arg?Glu?Gly?Ala?Pro?Asn?Leu?Tyr?Pro?Ala?Glu?Leu?Arg?Glu?Glu

170 175 180

atg?gcg?ccg?gtg?atg?aag?cgc?atc?ttc?act?gag?gtc?aac?aac?ggc?gta 691

Met?Ala?Pro?Val?Met?Lys?Arg?Ile?Phe?Thr?Glu?Val?Asn?Asn?Gly?Val

185 190 195

tac?agg?acc?ggc?ttt?gcc?ggt?agc?cag?gaa?gcg?cac?aac?gag?gcg?tac 739

Tyr?Arg?Thr?Gly?Phe?Ala?Gly?Ser?Gln?Glu?Ala?His?Asn?Glu?Ala?Tyr

200 205 210

aag?cgg?ctt?tgg?gtt?gcg?ttg?gac?tgg?cta?gaa?gat?cgc?tta?tcg?acg 787

Lys?Arg?Leu?Trp?Val?Ala?Leu?Asp?Trp?Leu?Glu?Asp?Arg?Leu?Ser?Thr

215 220 225

cga?cgt?tac?ctc?atg?ggg?gat?cac?atc?acc?gag?gcg?gat?atc?cgc?ctc 835

Arg?Arg?Tyr?Leu?Met?Gly?Asp?His?Ile?Thr?Glu?Ala?Asp?Ile?Arg?Leu

230 235 240 245

tac?cca?acc?ctc?gtg?cgt?ttc?gat?gcc?gtc?tac?cac?gga?cac?ttc?aag 883

Tyr?Pro?Thr?Leu?Val?Arg?Phe?Asp?Ala?Val?Tyr?His?Gly?His?Phe?Lys

250 255 260

tgt?ggc?cgc?aac?aag?atc?acc?gaa?atg?ccg?aat?cta?tgg?ggc?tac?ctg 931

Cys?Gly?Arg?Asn?Lys?Ile?Thr?Glu?Met?Pro?Asn?Leu?Trp?Gly?Tyr?Leu

265 270 275

cgg?gat?ctt?ttc?cag?acc?cca?ggc?ttt?ggc?gac?acc?acc?gat?ttc?acc 979

Arg?Asp?Leu?Phe?Gln?Thr?Pro?Gly?Phe?Gly?Asp?Thr?Thr?Asp?Phe?Thr

280 285 290

gaa?atc?aag?cag?cac?tac?tac?atc?acc?cac?gcg?gag?att?aac?ccc?acc 1027

Glu?Ile?Lys?Gln?His?Tyr?Tyr?Ile?Thr?His?Ala?Glu?Ile?Asn?Pro?Thr

295 300 305

cgg?atc?gtt?cca?gtc?gga?cca?gat?ctg?tct?ggt?ttc?gcg?aca?cca?cac 1075

Arg?Ile?Val?Pro?Val?Gly?Pro?Asp?Leu?Ser?Gly?Phe?Ala?Thr?Pro?His

310 315 320 325

ggc?cgt?gaa?aag?ctc?ggc?gga?tcc?cca?ttt?gct?gaa?ggt?gtt?act?ctg 1123

Gly?Arg?Glu?Lys?Leu?Gly?Gly?Ser?Pro?Phe?Ala?Glu?Gly?Val?Thr?Leu

330 335 340

cct?ggc?cca?att?cct?gcg?ggc?gaa?gaa?gtg?aaa?aac?cct?gaa?cct?ttt 1171

Pro?Gly?Pro?Ile?Pro?Ala?Gly?Glu?Glu?Val?Lys?Asn?Pro?Glu?Pro?Phe

345 350 355

cag?aag?taactaaggc?cgcaatccct?cga 1200

Gln?Lys

<210>740

<211>359

<212>PRT

＜213〉Corynebacterium glutamicum

<400>740

Val?Ala?Asn?Thr?Ser?Ser?Asp?Trp?Ala?Gly?Ala?Pro?Gln?Asn?Ala?Ser

1 5 10 15

Ala?Asp?Gly?Glu?Phe?Val?Arg?Asp?Thr?Asn?Tyr?Ile?Asp?Asp?Arg?Ile

20 25 30

Val?Ala?Asp?Val?Pro?Ala?Gly?Ser?Glu?Pro?Ile?Ala?Gln?Glu?Asp?Gly

35 40 45

Thr?Phe?His?Trp?Pro?Val?Glu?Ala?Gly?Arg?Tyr?Arg?Leu?Val?Ala?Ala

50 55 60

Arg?Ala?Cys?Pro?Trp?Ala?His?Arg?Thr?Val?Ile?Thr?Arg?Arg?Leu?Leu

65 70 75 80

Gly?Leu?Glu?Asn?Val?Ile?Ser?Leu?Gly?Leu?Thr?Gly?Pro?Thr?His?Asp

85 90 95

Val?Arg?Ser?Trp?Thr?Phe?Asp?Leu?Asp?Pro?Asn?His?Leu?Asp?Pro?Val

100 105 110

Leu?Gln?Ile?Pro?Arg?Leu?Gln?Asp?Ala?Tyr?Phe?Asn?Arg?Phe?Pro?Asp

115 120 125

Tyr?Pro?Arg?Gly?Ile?Thr?Val?Pro?Ala?Leu?Val?Glu?Glu?Ser?Ser?Lys

130 135 140

Lys?Val?Val?Thr?Asn?Asp?Tyr?Pro?Ser?Ile?Thr?Ile?Asp?Phe?Asn?Leu

145 150 155 160

Glu?Trp?Lys?Gln?Phe?His?Arg?Glu?Gly?Ala?Pro?Asn?Leu?Tyr?Pro?Ala

165 170 175

Glu?Leu?Arg?Glu?Glu?Met?Ala?Pro?Val?Met?Lys?Arg?Ile?Phe?Thr?Glu

180 185 190

Val?Asn?Asn?Gly?Val?Tyr?Arg?Thr?Gly?Phe?Ala?Gly?Ser?Gln?Glu?Ala

195 200 205

His?Asn?Glu?Ala?Tyr?Lys?Arg?Leu?Trp?Val?Ala?Leu?Asp?Trp?Leu?Glu

210 215 220

Asp?Arg?Leu?Ser?Thr?Arg?Arg?Tyr?Leu?Met?Gly?Asp?His?Ile?Thr?Glu

225 230 235 240

Ala?Asp?Ile?Arg?Leu?Tyr?Pro?Thr?Leu?Val?Arg?Phe?Asp?Ala?Val?Tyr

245 250 255

His?Gly?His?Phe?Lys?Cys?Gly?Arg?Asn?Lys?Ile?Thr?Glu?Met?Pro?Asn

260 265 270

Leu?Trp?Gly?Tyr?Leu?Arg?Asp?Leu?Phe?Gln?Thr?Pro?Gly?Phe?Gly?Asp

275 280 285

Thr?Thr?Asp?Phe?Thr?Glu?Ile?Lys?Gln?His?Tyr?Tyr?Ile?Thr?His?Ala

290 295 300

Glu?Ile?Asn?Pro?Thr?Arg?Ile?Val?Pro?Val?Gly?Pro?Asp?Leu?Ser?Gly

305 310 315 320

Phe?Ala?Thr?Pro?His?Gly?Arg?Glu?Lys?Leu?Gly?Gly?Ser?Pro?Phe?Ala

325 330 335

Glu?Gly?Val?Thr?Leu?Pro?Gly?Pro?Ile?Pro?Ala?Gly?Glu?Glu?Val?Lys

340 345 350

Asn?Pro?Glu?Pro?Phe?Gln?Lys

355

<210>741

<211>1227

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1204)

<223>RXA00800

<400>741

gactccgcag?ggatggccta?caagtacggt?cacggactta?atttctagat?tgtaggtagt?60

ctcgtgggca?caactgaaat?cttattgaaa?aggagtgtcc?atg?agc?act?gta?gtg 115

Met?Ser?Thr?Val?Val

1 5

cct?gga?att?gtc?gca?ctg?tcc?aag?ggt?gca?ccg?gta?gaa?aaa?gta?aac 163

Pro?Gly?Ile?Val?Ala?Leu?Ser?Lys?Gly?Ala?Pro?Val?Glu?Lys?Val?Asn

10 15 20

gtt?gtt?gtc?cct?gat?cca?ggt?gct?aac?gat?gtc?atc?gtc?aag?att?cag 211

Val?Val?Val?Pro?Asp?Pro?Gly?Ala?Asn?Asp?Val?Ile?Val?Lys?Ile?Gln

25 30 35

gcc?tgc?ggt?gtg?tgc?cac?acc?gac?ttg?gcc?tac?cgc?gat?ggc?gat?att 259

Ala?Cys?Gly?Val?Cys?His?Thr?Asp?Leu?Ala?Tyr?Arg?Asp?Gly?Asp?Ile

40 45 50

tca?gat?gag?ttc?cct?tac?ctc?ctc?ggc?cac?gag?gca?gca?ggc?att?gtt 307

Ser?Asp?Glu?Phe?Pro?Tyr?Leu?Leu?Gly?His?Glu?Ala?Ala?Gly?Ile?Val

55 60 65

gag?gag?gta?ggc?gag?tcc?gtc?acc?cac?gtt?gag?gtc?ggc?gat?ttc?gtc 355

Glu?Glu?Val?Gly?Glu?Ser?Val?Thr?His?Val?Glu?Val?Gly?Asp?Phe?Val

70 75 80 85

atc?ttg?aac?tgg?cgt?gca?gtg?tgc?ggc?gag?tgc?cgt?gca?tgt?aag?aag 403

Ile?Leu?Asn?Trp?Arg?Ala?ValCys?Gly?Glu?Cys?Arg?Ala?Cys?Lys?Lys

90 95 100

ggc?gag?cca?aag?tac?tgc?ttt?aac?acc?cac?aac?gcc?tct?aag?aag?atg 451

Gly?Glu?Pro?Lys?Tyr?Cys?Phe?Asn?Thr?His?Asn?Ala?Ser?Lys?Lys?Met

105 110 115

acc?ctg?gaa?gac?ggc?acc?gag?ctg?tcc?cca?gca?ctg?ggt?att?ggc?gcg 499

Thr?Leu?Glu?Asp?Gly?Thr?Glu?Leu?Ser?Pro?Ala?Leu?Gly?Ile?Gly?Ala

120 125 130

ttc?ttg?gaa?aag?acc?ctg?gtc?cac?gaa?ggc?cag?tgc?acc?aag?gtt?aac 547

Phe?Leu?Glu?Lys?Thr?Leu?Val?His?Glu?Gly?Gln?Cys?Thr?Lys?Val?Asn

135 140 145

cct?gag?gaa?gat?cca?gca?gca?gct?ggc?ctt?ctg?ggt?tgt?ggc?atc?atg 595

Pro?Glu?Glu?Asp?Pro?Ala?Ala?Ala?Gly?Leu?Leu?Gly?Cys?Gly?Ile?Met

150 155 160 165

gca?ggc?ctt?ggc?gct?gcg?gtg?aac?acc?ggt?gat?att?aag?cgt?ggc?gag 643

Ala?Gly?Leu?Gly?Ala?Ala?Val?Asn?Thr?Gly?Asp?Ile?Lys?Arg?Gly?Glu

170 175 180

tcc?gta?gca?gtc?ttc?ggc?ctt?ggt?ggc?gtg?ggc?atg?gca?gct?att?gct 691

Ser?Val?Ala?Val?Phe?Gly?Leu?Gly?Gly?Val?Gly?Met?Ala?Ala?Ile?Ala

185 190 195

ggc?gcc?aag?att?gct?ggc?gct?tcc?aag?atc?att?gct?gtt?gat?atc?gat 739

Gly?Ala?Lys?Ile?Ala?Gly?Ala?Ser?Lys?Ile?Ile?Ala?Val?Asp?Ile?Asp

200 205 210

gag?aag?aag?ctg?gag?tgg?gcg?aag?gaa?ttc?ggc?gca?acc?cac?acc?att 787

Glu?Lys?Lys?Leu?Glu?Trp?Ala?Lys?Glu?Phe?Gly?Ala?Thr?His?Thr?Ile

215 220 225

aat?tcc?tct?ggt?ctt?ggt?ggc?gaa?ggt?gat?gcc?tct?gag?gtc?gtg?gca 835

Asn?Ser?Ser?Gly?Leu?Gly?Gly?Glu?Gly?Asp?Ala?Ser?Glu?Val?Val?Ala

230 235 240 245

aag?gtt?cgt?gag?ctc?acc?gat?ggt?ttc?ggc?acc?gat?gtc?tcc?atc?gat 883

Lys?Val?Arg?Glu?Leu?Thr?Asp?Gly?Phe?Gly?Thr?Asp?Val?Ser?Ile?Asp

250 255 260

gcg?gta?ggc?atc?atg?ccg?acc?tgg?cag?cag?gcg?ttt?tac?tcc?cgt?gac 931

Ala?Val?Gly?Ile?Met?Pro?Thr?Trp?Gln?Gln?Ala?Phe?Tyr?Ser?Arg?Asp

265 270 275

cat?gca?ggc?cgc?atg?gtg?atg?gtg?ggc?gtt?cca?aac?ctg?acg?tct?cgc 979

His?Ala?Gly?Arg?Met?Val?Met?Val?Gly?Val?Pro?Asn?Leu?Thr?Ser?Arg

280 285 290

gta?gat?gtt?cct?gcg?att?gat?ttt?tac?ggt?cgc?ggt?gga?tcc?gtg?cgc 1027

Val?Asp?Val?Pro?Ala?Ile?Asp?Phe?Tyr?Gly?Arg?Gly?Gly?Ser?Val?Arg

295 300 305

cct?gca?tgg?tac?ggc?gac?tgc?ctg?cct?gag?cgt?gat?ttc?cca?act?tat 1075

Pro?Ala?Trp?Tyr?Gly?Asp?Cys?Leu?Pro?Glu?Arg?Asp?Phe?Pro?Thr?Tyr

310 315 320 325

gtg?gat?ctg?cac?ctg?cag?ggt?cgt?ttc?cca?ctg?gat?aag?ttt?gtt?tct 1123

Val?Asp?Leu?His?Leu?Gln?Gly?Arg?Phe?Pro?Leu?Asp?Lys?Phe?Val?Ser

330 335 340

gag?cgt?att?ggt?ctt?gat?gat?gtt?gaa?gag?gct?ttc?aac?acc?atg?aag 1171

Glu?Arg?Ile?Gly?Leu?Asp?Asp?Val?Glu?Glu?Ala?Phe?Asn?Thr?Met?Lys

345 350 355

gct?ggc?gac?gtg?ctg?cgt?tct?gtg?gtg?gag?atc?taaatggctc?acgacggatt?1224

Ala?Gly?Asp?Val?Leu?Arg?Ser?Val?Val?Glu?Ile

360 365

gcg 1227

<210>742

<211>368

<212>PRT

＜213〉Corynebacterium glutamicum

<400>742

Met?Ser?Thr?Val?Val?Pro?Gly?Ile?Val?Ala?Leu?Ser?Lys?Gly?Ala?Pro

1 5 10 15

Val?Glu?Lys?Val?Asn?Val?Val?Val?Pro?Asp?Pro?Gly?Ala?Asn?Asp?Val

20 25 30

Ile?Val?Lys?Ile?Gln?Ala?Cys?Gly?Val?Cys?His?Thr?Asp?Leu?Ala?Tyr

35 40 45

Arg?Asp?Gly?Asp?Ile?Ser?Asp?Glu?Phe?Pro?Tyr?Leu?Leu?Gly?His?Glu

50 55 60

Ala?Ala?Gly?Ile?Val?Glu?Glu?Val?Gly?Glu?Ser?Val?Thr?His?Val?Glu

65 70 75 80

Val?Gly?Asp?Phe?Val?Ile?Leu?Asn?Trp?Arg?Ala?Val?Cys?Gly?Glu?Cys

85 90 95

Arg?Ala?Cys?Lys?Lys?Gly?Glu?Pro?Lys?Tyr?Cys?Phe?Asn?Thr?His?Asn

100 105 110

Ala?Ser?Lys?Lys?Met?Thr?Leu?Glu?Asp?Gly?Thr?Glu?Leu?Ser?Pro?Ala

115 120 125

Leu?Gly?Ile?Gly?Ala?Phe?Leu?Glu?Lys?Thr?Leu?Val?His?Glu?Gly?Gln

130 135 140

Cys?Thr?Lys?Val?Asn?Pro?Glu?Glu?Asp?Pro?Ala?Ala?Ala?Gly?Leu?Leu

145 150 155 160

Gly?Cys?Gly?Ile?Met?Ala?Gly?Leu?Gly?Ala?Ala?Val?Asn?Thr?Gly?Asp

165 170 175

Ile?Lys?Arg?Gly?Glu?Ser?Val?Ala?Val?Phe?Gly?Leu?Gly?Gly?Val?Gly

180 185 190

Met?Ala?Ala?Ile?Ala?Gly?Ala?Lys?Ile?Ala?Gly?Ala?Ser?Lys?Ile?Ile

195 200 205

Ala?Val?Asp?Ile?Asp?Glu?Lys?Lys?Leu?Glu?Trp?Ala?Lys?Glu?Phe?Gly

210 215 220

Ala?Thr?His?Thr?Ile?Asn?Ser?Ser?Gly?Leu?Gly?Gly?Glu?Gly?Asp?Ala

225 230 235 240

Ser?Glu?Val?Val?Ala?Lys?Val?Arg?Glu?Leu?Thr?Asp?Gly?Phe?Gly?Thr

245 250 255

Asp?Val?Ser?Ile?Asp?Ala?Val?Gly?Ile?Met?Pro?Thr?Trp?Gln?Gln?Ala

260 265 270

Phe?Tyr?Ser?Arg?Asp?His?Ala?Gly?Arg?Met?Val?Met?Val?Gly?Val?Pro

275 280 285

Asn?Leu?Thr?Ser?Arg?Val?Asp?Val?Pro?Ala?Ile?Asp?Phe?Tyr?Gly?Arg

290 295 300

Gly?Gly?Ser?Val?Arg?Pro?Ala?Trp?Tyr?Gly?Asp?Cys?Leu?Pro?Glu?Arg

305 310 315 320

Asp?Phe?Pro?Thr?Tyr?Val?Asp?Leu?His?Leu?Gln?Gly?Arg?Phe?Pro?Leu

325 330 335

Asp?Lys?Phe?Val?Ser?Glu?Arg?Ile?Gly?Leu?Asp?Asp?Val?Glu?Glu?Ala

340 345 350

Phe?Asn?Thr?Met?Lys?Ala?Gly?Asp?Val?Leu?Arg?Ser?Val?Val?Glu?Ile

355 360 365

<210>743

<211>1011

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(988)

<223>RXA02143

<400>743

tcttcatcac?tatttacttc?attcagtagg?cagtaaggaa?tcctcaacgt?tgttgaggtt?60

ccctatgccc?ttcacttcca?cagtcgagat?tcaaagggaa?atg?atg?gaa?acc?aac 115

Met?Met?Glu?Thr?Asn

1 5

ccg?cag?acc?cca?gag?gga?aat?agc?atg?gct?aaa?ccc?tct?gct?aag?aag 163

Pro?Gln?Thr?Pro?Glu?Gly?Asn?Ser?Met?Ala?Lys?Pro?Ser?Ala?Lys?Lys

10 15 20

gtc?aag?aat?cgc?cgc?aag?gtc?cgg?cgc?acc?gtc?gca?ggt?gca?ttg?gct 211

Val?Lys?Asn?Arg?Arg?Lys?Val?Arg?Arg?Thr?Val?Ala?Gly?Ala?Leu?Ala

25 30 35

ctg?acc?att?gga?ctg?agc?gga?gca?gga?atc?ctc?gca?acc?gcg?atc?act 259

Leu?Thr?Ile?Gly?Leu?Ser?Gly?Ala?Gly?Ile?Leu?Ala?Thr?Ala?Ile?Thr

40 45 50

cca?gat?gct?caa?gtt?gct?acc?gct?cag?cgt?gac?gat?cag?gca?ctt?atc 307

Pro?Asp?Ala?Gln?Val?Ala?Thr?Ala?Gln?Arg?Asp?Asp?Gln?Ala?Leu?Ile

55 60 65

tcc?gag?ggt?aaa?gac?ctc?tac?gat?gtc?gcc?tgc?atc?acc?tgc?cac?ggc 355

Ser?Glu?Gly?Lys?Asp?Leu?Tyr?Asp?Val?Ala?Cys?Ile?Thr?Cys?His?Gly

70 75 80 85

gta?aac?ctc?caa?ggt?gtt?gag?gac?cgc?ggt?cct?tcc?ctc?gta?ggt?gtt 403

Val?Asn?Leu?Gln?Gly?Val?Glu?Asp?Arg?Gly?Pro?Ser?Leu?Val?Gly?Val

90 95 100

ggc?gaa?ggc?gca?gtg?tac?ttc?caa?gtt?cac?tcc?ggc?cgt?atg?cca?ata 451

Gly?Glu?Gly?Ala?Val?Tyr?Phe?Gln?Val?His?Ser?Gly?Arg?Met?Pro?Ile

105 110 115

ctg?cgt?aac?gag?gct?cag?gct?gag?cgc?aag?gct?cct?cgt?tac?acc?gag 499

Leu?Arg?Asn?Glu?Ala?Gln?Ala?Glu?Arg?Lys?Ala?Pro?Arg?Tyr?Thr?Glu

120 125 130

gca?cag?acc?ctt?gcg?atc?gct?gca?tat?gtt?gca?gct?aat?ggc?ggt?ggc 547

Ala?Gln?Thr?Leu?Ala?Ile?Ala?Ala?Tyr?Val?Ala?Ala?Asn?Gly?Gly?Gly

135 140 145

cca?gga?ctc?gtt?tac?aac?gag?gac?ggc?acc?ctc?gcc?atg?gag?gag?ctc 595

Pro?Gly?Leu?Val?Tyr?Asn?Glu?Asp?Gly?Thr?Leu?Ala?Met?Glu?Glu?Leu

150 155 160 165

cgt?ggc?gaa?aac?tac?gac?gga?cag?att?acc?tcc?gcc?gac?gtc?gct?cgc 643

Arg?Gly?Glu?Asn?Tyr?Asp?Gly?Gln?Ile?Thr?Ser?Ala?Asp?Val?Ala?Arg

170 175 180

ggc?gga?gat?ctg?ttc?cgc?ctg?aac?tgt?gca?tcc?tgc?cac?aac?ttc?act 691

Gly?Gly?Asp?Leu?Phe?Arg?Leu?Asn?Cys?Ala?Ser?Cys?His?Asn?Phe?Thr

185 190 195

ggt?cgt?ggt?ggc?gca?ctg?tcc?tct?ggt?aag?tac?gca?cca?aac?ctg?gat 739

Gly?Arg?Gly?Gly?Ala?Leu?Ser?Ser?Gly?Lys?Tyr?Ala?Pro?Asn?Leu?Asp

200 205 210

gct?gca?aac?gag?cag?gaa?atc?tac?cag?gct?atg?ctt?acc?ggt?cct?cag 787

Ala?Ala?Asn?Glu?Gln?Glu?Ile?Tyr?Gln?Ala?Met?Leu?Thr?Gly?Pro?Gln

215 220 225

aac?atg?cct?aag?ttc?tcc?gat?cgt?cag?ctc?tcc?gca?gat?gag?aag?aag 835

Asn?Met?Pro?Lys?Phe?Ser?Asp?Arg?Gln?Leu?Ser?Ala?Asp?Glu?Lys?Lys

230 235 240 245

gac?atc?atc?gcc?ttc?atc?aag?tcc?acc?aag?gag?act?cca?tca?cct?ggt 883

Asp?Ile?Ile?Ala?Phe?Ile?Lys?Ser?Thr?Lys?Glu?Thr?Pro?Ser?Pro?Gly

250 255 260

ggt?tac?tca?ctc?ggt?agc?ttg?ggc?cca?gtg?gct?gag?ggt?ctg?ttc?atg 931

Gly?Tyr?Ser?Leu?Gly?Ser?Leu?Gly?Pro?Val?Ala?Glu?Gly?Leu?Phe?Met

265 270 275

tgg?gta?ttc?ggc?atc?ttg?gtc?ctc?gtg?gcc?gcc?gct?atg?tgg?att?gga 979

Trp?Val?Phe?Gly?Ile?Leu?Val?Leu?Val?Ala?Ala?Ala?Met?Trp?Ile?Gly

280 285 290

tca?cgt?tca?tgagtaacaa?caacgacaaa?cag 1011

Ser?Arg?Ser

295

<210>744

<211>296

<212>PRT

＜213〉Corynebacterium glutamicum

<400>744

Met?Met?Glu?Thr?Asn?Pro?Gln?Thr?Pro?Glu?Gly?Asn?Ser?Met?Ala?Lys

1 5 10 15

Pro?Ser?Ala?Lys?Lys?Val?Lys?Asn?Arg?Arg?Lys?Val?Arg?Arg?Thr?Val

20 25 30

Ala?Gly?Ala?Leu?Ala?Leu?Thr?Ile?Gly?Leu?Ser?Gly?Ala?Gly?Ile?Leu

35 40 45

Ala?Thr?Ala?Ile?Thr?Pro?Asp?Ala?Gln?Val?Ala?Thr?Ala?Gln?Arg?Asp

50 55 60

Asp?Gln?Ala?Leu?Ile?Ser?Glu?Gly?Lys?Asp?Leu?Tyr?Asp?Val?Ala?Cys

65 70 75 80

Ile?Thr?Cys?His?Gly?Val?Asn?Leu?Gln?Gly?Val?Glu?Asp?Arg?Gly?Pro

85 90 95

Ser?Leu?Val?Gly?Val?Gly?Glu?Gly?Ala?Val?Tyr?Phe?Gln?Val?His?Ser

100 105 110

Gly?Arg?Met?Pro?Ile?Leu?Arg?Asn?Glu?Ala?Gln?Ala?Glu?Arg?Lys?Ala

115 120 125

Pro?Arg?Tyr?Thr?Glu?Ala?Gln?Thr?Leu?Ala?Ile?Ala?Ala?Tyr?Val?Ala

130 135 140

Ala?Asn?Gly?Gly?Gly?Pro?Gly?Leu?Val?Tyr?Asn?Glu?Asp?Gly?Thr?Leu

145 150 155 160

Ala?Met?Glu?Glu?Leu?Arg?Gly?Glu?Asn?Tyr?Asp?Gly?Gln?Ile?Thr?Ser

165 170 175

Ala?Asp?Val?Ala?Arg?Gly?Gly?Asp?Leu?Phe?Arg?Leu?Asn?Cys?Ala?Ser

180 185 190

Cys?His?Asn?Phe?Thr?Gly?Arg?Gly?Gly?Ala?Leu?Ser?Ser?Gly?Lys?Tyr

195 200 205

Ala?Pro?Asn?Leu?Asp?Ala?Ala?Asn?Glu?Gln?Glu?Ile?Tyr?Gln?Ala?Met

210 215 220

Leu?Thr?Gly?Pro?Gln?Asn?Met?Pro?Lys?Phe?Ser?Asp?Arg?Gln?Leu?Ser

225 230 235 240

Ala?Asp?Glu?Lys?Lys?Asp?Ile?Ile?Ala?Phe?Ile?Lys?Ser?Thr?Lys?Glu

245 250 255

Thr?Pro?Ser?Pro?Gly?Gly?Tyr?Ser?Leu?Gly?Ser?Leu?Gly?Pro?Val?Ala

260 265 270

Glu?Gly?Leu?Phe?Met?Trp?Val?Phe?Gly?Ile?Leu?Val?Leu?Val?Ala?Ala

275 280 285

Ala?Met?Trp?Ile?Gly?Ser?Arg?Ser

290 295

<210>745

<211>502

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(502)

<223>RXN03096

<400>745

aagatcatgc?tcatcgaagc?cggcgcccga?agatggcagt?tggctggcat?gggtccttat?60

cgcaggcgcc?gttgtcacct?cactgctcac?cttgtacacc?atg?gtt?ctg?gtc?tgg 115

Met?Val?Leu?Val?Trp

1 5

tcc?aag?gcc?ttc?tgg?cgc?gac?cgt?aaa?gac?gcc?ccc?gat?gga?gca?acc 163

Ser?Lys?Ala?Phe?Trp?Arg?Asp?Arg?Lys?Asp?Ala?Pro?Asp?Gly?Ala?Thr

10 15 20

gca?cta?gca?aga?ccc?gca?cct?ttg?gta?gat?atc?caa?gac?gaa?gtc?gcc 211

Ala?Leu?Ala?Arg?Pro?Ala?Pro?Leu?Val?Asp?Ile?Gln?Asp?Glu?Val?Ala

25 30 35

gtt?aaa?gac?cgc?aac?gat?gtc?gga?cgg?atg?cct?tgg?ggc?atg?gtc?ttc 259

ValLys?Asp?Arg?Asn?Asp?Val?Gly?Arg?Met?Pro?Trp?Gly?Met?Val?Phe

40 45 50

tcc?act?gcc?ctg?ttg?gtt?tcc?gca?tcc?ctt?gct?gta?tcc?gtg?ctc?gca 307

Ser?Thr?Ala?Leu?Leu?Val?Ser?Ala?Ser?Leu?Ala?Val?Ser?Val?Leu?Ala

55 60 65

gga?cca?ctg?tca?tct?att?act?gga?cgc?gcc?gcc?gaa?tcc?gca?caa?gat 355

Gly?Pro?Leu?Ser?Ser?Ile?Thr?Gly?Arg?Ala?Ala?Glu?Ser?Ala?Gln?Asp

70 75 80 85

gtc?aac?atc?tac?cgc?gcc?gca?gta?ctc?ggc?cca?act?acc?tcg?acc?cat 403

Val?Asn?Ile?Tyr?Arg?Ala?Ala?Val?Leu?Gly?Pro?Thr?Thr?Ser?Thr?His

90 95 100

cac?gca?cac?tcg?aga?tgg?agc?gtt?acg?acg?cca?acc?gcg?atg?aca?tca 451

His?Ala?His?Ser?Arg?Trp?Ser?Val?Thr?Thr?Pro?Thr?Ala?Met?Thr?Ser

105 110 115

acc?acc?gcg?tcg?aca?cca?atg?gaa?cgg?agg?acc?aac?cat?gat?cag?tgg 499

Thr?Thr?Ala?Ser?Thr?Pro?Met?Glu?Arg?Arg?Thr?Asn?His?Asp?Gln?Trp

120 125 130

att 502

Ile

<210>746

<211>134

<212>PRT

＜213〉Corynebacterium glutamicum

<400>746

Met?Val?Leu?Val?Trp?Ser?Lys?Ala?Phe?Trp?Arg?Asp?Arg?Lys?Asp?Ala

1 5 10 15

Pro?Asp?Gly?Ala?Thr?Ala?Leu?Ala?Arg?Pro?Ala?Pro?Leu?Val?Asp?Ile

20 25 30

Gln?Asp?Glu?Val?Ala?Val?Lys?Asp?Arg?Asn?Asp?Val?Gly?Arg?Met?Pro

35 40 45

Trp?Gly?Met?Val?Phe?Ser?Thr?Ala?Leu?Leu?Val?Ser?Ala?Ser?Leu?Ala

50 55 60

Val?Ser?Val?Leu?Ala?Gly?Pro?Leu?Ser?Ser?Ile?Thr?Gly?Arg?Ala?Ala

65 70 75 80

Glu?Ser?Ala?Gln?Asp?Val?Asn?Ile?Tyr?Arg?Ala?Ala?Val?Leu?Gly?Pro

85 90 95

Thr?Thr?Ser?Thr?His?His?Ala?His?Ser?Arg?Trp?Ser?Val?Thr?Thr?Pro

100 105 110

Thr?Ala?Met?Thr?Ser?Thr?Thr?Ala?Ser?Thr?Pro?Met?Glu?Arg?Arg?Thr

115 120 125

Asn?His?Asp?Gln?Trp?Ile

130

<210>747

<211>504

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(481)

<223>RXN02036

<400>747

ctaaaatgga?aggcaatgga?tacccgccgc?atgaacctcc?gccaatggaa?aatcctcgtt?60

gccctcatct?ctgctgcagt?ggcggctctc?ggagggtggt?gtg?cat?att?cct?ttt 115

Val?His?Ile?Pro?Phe

1 5

ggg?cac?ctc?gcc?gac?acc?gtc?tcc?tgg?gac?tgc?ggg?gga?ggc?agc?tgc 163

Gly?His?Leu?Ala?Asp?Thr?Val?Ser?Trp?Asp?Cys?Gly?Gly?Gly?Ser?Cys

10 15 20

gcc?acc?aac?gat?ttg?gta?tcc?ctg?ttc?atg?ccg?gcc?gcc?ttc?atg?agt 211

Ala?Thr?Asn?Asp?Leu?Val?Ser?Leu?Phe?Met?Pro?Ala?Ala?Phe?Met?Ser

25 30 35

acc?ctc?gcc?gcc?tgc?gta?ttt?ggc?gcg?tgg?gcc?ata?ggt?ttg?atc?gct 259

Thr?Leu?Ala?Ala?Cys?Val?Phe?Gly?Ala?Trp?Ala?Ile?Gly?Leu?Ile?Ala

40 45 50

ccc?gca?cta?ttc?atc?gcg?gtg?act?gcc?tgg?gca?ttt?cgc?tcc?ggc?gtg 307

Pro?Ala?Leu?Phe?Ile?Ala?Val?Thr?Ala?Trp?Ala?Phe?Arg?Ser?Gly?Val

55 60 65

cag?gct?gcg?att?gcc?gac?ggc?tac?acg?tcc?gcg?act?tcc?gtc?ggc?ttc 355

Gln?Ala?Ala?Ile?Ala?Asp?Gly?Tyr?Thr?Ser?Ala?Thr?Ser?Val?Gly?Phe

70 75 80 85

gaa?atg?act?gtc?tcg?ctc?att?ctt?ttc?atc?atc?gca?ggt?ctg?tgc?ttt 403

Glu?Met?Thr?Val?Ser?Leu?Ile?Leu?Phe?Ile?Ile?Ala?Gly?Leu?Cys?Phe

90 95 100

ctg?ggc?tgg?atc?ccc?atg?ttc?atc?aac?aac?cgc?caa?gtc?gcg?cgc?aag 451

Leu?Gly?Trp?Ile?Pro?Met?Phe?Ile?Asn?Asn?Arg?Gln?Val?Ala?Arg?Lys

105 110 115

gtc?cgc?gag?agg?gct?gcg?ggc?ttg?agc?aat?taggctctcg?cttttcgacg 501

Val?Arg?Glu?Arg?Ala?Ala?Gly?Leu?Ser?Asn

120 125

ttt 504

<210>748

<211>127

<212>PRT

＜213〉Corynebacterium glutamicum

<400>748

Val?His?Ile?Pro?Phe?Gly?His?Leu?Ala?Asp?Thr?Val?Ser?Trp?Asp?Cys

1 5 10 15

Gly?Gly?Gly?Ser?Cys?Ala?Thr?Asn?Asp?Leu?Val?Ser?Leu?Phe?Met?Pro

20 25 30

Ala?Ala?Phe?Met?Ser?Thr?Leu?Ala?Ala?Cys?Val?Phe?Gly?Ala?Trp?Ala

35 40 45

Ile?Gly?Leu?Ile?Ala?Pro?Ala?Leu?Phe?Ile?Ala?Val?Thr?Ala?Trp?Ala

50 55 60

Phe?Arg?Ser?Gly?Val?Gln?Ala?Ala?Ile?Ala?Asp?Gly?Tyr?Thr?Ser?Ala

65 70 75 80

Thr?Ser?Val?Gly?Phe?Glu?Met?Thr?Val?Ser?Leu?Ile?Leu?Phe?Ile?Ile

85 90 95

Ala?Gly?Leu?Cys?Phe?Leu?Gly?Trp?Ile?Pro?Met?Phe?Ile?Asn?Asn?Arg

100 105 110

Gln?Val?Ala?Arg?Lys?Val?Arg?Glu?Arg?Ala?Ala?Gly?Leu?Ser?Asn

115 120 125

<210>749

<211>882

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(859)

<223>RXN02765

<400>749

tctgaacttt?tccgcatcga?cccagatgag?gtttaccccg?acgacgacgc?cacctgcgaa?60

ttcaacccat?ggccgtatcc?tcgcggattt?taggagataa?atg?tct?aat?caa?tta 115

Met?Ser?Asn?Gln?Leu

1 5

ccc?gat?cac?gtc?cgc?gac?gcc?ttc?caa?gta?ggt?gcg?gga?cct?gcc?gaa 163

Pro?Asp?His?Val?Arg?Asp?Ala?Phe?Gln?Val?Gly?Ala?Gly?Pro?Ala?Glu

10 15 20

caa?ctc?ggt?caa?gct?tgg?gac?ttc?gga?ttc?cgc?gtc?ggc?aac?act?gtg 211

Gln?Leu?Gly?Gln?Ala?Trp?Asp?Phe?Gly?Phe?Arg?Val?Gly?Asn?Thr?Val

25 30 35

ttc?gcc?aaa?gtg?acg?gcg?ccg?gaa?gtg?tcg?ggc?tgg?tcg?tcg?aaa?acc 259

Phe?Ala?Lys?Val?Thr?Ala?Pro?Glu?Val?Ser?Gly?Trp?Ser?Ser?Lys?Thr

40 45 50

cgc?gaa?acc?ctg?aaa?cca?gaa?ggc?gtg?cgc?gtc?gta?cga?ccg?atc?cgc 307

Arg?Glu?Thr?Leu?Lys?Pro?Glu?Gly?Val?Arg?Val?Val?Arg?Pro?Ile?Arg

55 60 65

tcc?acc?gac?ggc?cga?ttt?gtg?gtt?gcg?ggg?tgg?cgc?gca?tcg?gtg?ttc 355

Ser?Thr?Asp?Gly?Arg?Phe?Val?Val?Ala?Gly?Trp?Arg?Ala?Ser?Val?Phe

70 75 80 85

tct?acg?gga?acg?atc?agc?aag?cga?gtc?gat?gag?acg?gtc?gtt?gcg?ggt 403

Ser?Thr?Gly?Thr?Ile?Ser?Lys?Arg?Val?Asp?Glu?Thr?Val?Val?Ala?Gly

90 95 100

ctt?cgt?ttg?gca?gat?gca?tta?gtg?gat?acg?cat?gca?ccg?gaa?cct?gtg 451

Leu?Arg?Leu?Ala?Asp?Ala?Leu?Val?Asp?Thr?His?Ala?Pro?Glu?Pro?Val

105 110 115

gac?aat?gtg?ttt?aac?cgt?gct?gat?gtg?cag?gcc?tgg?gaa?gag?cag?ccc 499

Asp?Asn?Val?Phe?Asn?Arg?Ala?Asp?Val?Gln?Ala?Trp?Glu?Glu?Gln?Pro

120 125 130

ggt?cga?atc?ggt?gaa?ttg?ttg?gag?ccg?att?aat?cgc?gtg?aac?cag?gtt 547

Gly?Arg?Ile?Gly?Glu?Leu?Leu?Glu?Pro?Ile?Asn?Arg?Val?Asn?Gln?Val

135 140 145

ggt?cat?gcg?gat?atg?ttg?gcg?aca?acg?ctg?tat?gcg?gga?act?cag?cca 595

Gly?His?Ala?Asp?Met?Leu?Ala?Thr?Thr?Leu?Tyr?Ala?Gly?Thr?Gln?Pro

150 155 160 165

cct?gca?gtg?acg?gat?ttg?gtg?cca?gtg?ctg?cgt?ccg?cat?ggt?ttc?act 643

Pro?Ala?Val?Thr?Asp?Leu?Val?Pro?Val?Leu?Arg?Pro?His?Gly?Phe?Thr

170 175 180

gcg?gca?ttg?gtg?atc?gtt?gat?ggg?ttg?ctg?ctg?ggt?gcg?gtt?gat?gag 691

Ala?Ala?Leu?Val?Ile?Val?Asp?Gly?Leu?Leu?Leu?Gly?Ala?Val?Asp?Glu

185 190 195

gga?att?ctg?cgg?agg?ttt?tcg?cat?ttg?ccg?gaa?att?gag?cag?ctg?gtt 739

Gly?Ile?Leu?Arg?Arg?Phe?Ser?His?Leu?Pro?Glu?Ile?Glu?Gln?Leu?Val

200 205 210

ttg?agg?gca?ttt?ttg?tte?cgt?cga?aac?ttg?cag?gag?ttc?tct?gag?aac 787

Leu?Arg?Ala?Phe?Leu?Phe?Arg?Arg?Asn?Leu?Gln?Glu?Phe?Ser?Glu?Asn

215 220 225

aac?gat?ecg?aat?gtt?att?tcg?aac?cta?aac?agg?gtg?gaa?tcg?aca?ctc 835

Asn?Asp?Pro?Asn?Val?Ile?Ser?Asn?Leu?Asn?Arg?Val?Glu?Ser?Thr?Leu

230 235 240 245

gtg?tcg?tat?gtt?tct?gac?aag?att?tgaggtatgt?cggaatacaa?acc 882

Val?Ser?Tyr?Val?Ser?Asp?Lys?Ile

250

<210>750

<211>253

<212>PRT

＜213〉Corynebacterium glutamicum

<400>750

Met?Ser?Asn?Gln?Leu?Pro?Asp?His?Val?Arg?Asp?Ala?Phe?Gln?Val?Gly

1 5 10 15

Ala?Gly?Pro?Ala?Glu?Gln?Leu?Gly?Gln?Ala?Trp?Asp?Phe?Gly?Phe?Arg

20 25 30

Val?Gly?Asn?Thr?Val?Phe?Ala?Lys?Val?Thr?Ala?Pro?Glu?Val?Ser?Gly

35 40 45

Trp?Ser?Ser?Lys?Thr?Arg?Glu?Thr?Leu?Lys?Pro?Glu?Gly?Val?Arg?Val

50 55 60

Val?Arg?Pro?Ile?Arg?Ser?Thr?Asp?Gly?Arg?Phe?Val?Val?Ala?Gly?Trp

65 70 75 80

Arg?Ala?Ser?Val?Phe?Ser?Thr?Gly?Thr?Ile?Ser?Lys?Arg?Val?Asp?Glu

85 90 95

Thr?Val?Val?Ala?Gly?Leu?Arg?Leu?Ala?Asp?Ala?Leu?Val?Asp?Thr?His

100 105 110

Ala?Pro?Glu?Pro?Val?Asp?Asn?Val?Phe?Asn?Arg?Ala?Asp?Val?Gln?Ala

115 120 125

Trp?Glu?Glu?Gln?Pro?Gly?Arg?Ile?Gly?Glu?Leu?Leu?Glu?Pro?Ile?Asn

130 135 140

Arg?Val?Asn?Gln?Val?Gly?His?Ala?Asp?Met?Leu?Ala?Thr?Thr?Leu?Tyr

145 150 155 160

Ala?Gly?Thr?Gln?Pro?Pro?Ala?Val?Thr?Asp?Leu?Val?Pro?Val?Leu?Arg

165 170 175

Pro?His?Gly?Phe?Thr?Ala?Ala?Leu?Val?Ile?Val?Asp?Gly?Leu?Leu?Leu

180 185 190

Gly?Ala?Val?Asp?Glu?Gly?Ile?Leu?Arg?Arg?Phe?Ser?His?Leu?Pro?Glu

195 200 205

Ile?Glu?Gln?Leu?Val?Leu?Arg?Ala?Phe?Leu?Phe?Arg?Arg?Asn?Leu?Gln

210 215 220

Glu?Phe?Ser?Glu?Asn?Asn?Asp?Pro?Asn?Val?Ile?Ser?Asn?Leu?Asn?Arg

225 230 235 240

Val?Glu?Ser?Thr?Leu?Val?Ser?Tyr?Val?Ser?Asp?Lys?Ile

245 250

<210>751

<211>1059

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1036)

<223>RXN02206

<400>751

ggcaggatct?gctgctgcgg?ctaggagggt?tatctcttca?ttcacccgat?ctaccgtact?60

accttatgac?ctcagtagtg?tggtgggcgt?gaaacagcga?atg?gtc?ggt?tca?agt 115

Met?Val?Gly?Ser?Ser

1 5

ggt?ttg?cgg?gta?tcc?agg?ctc?ggt?ttg?ggc?acc?tca?aca?tgg?ggc?tcg 163

Gly?Leu?Arg?Val?Ser?Arg?Leu?Gly?Leu?Gly?Thr?Ser?Thr?Trp?Gly?Ser

10 15 20

ggc?acc?gag?ctg?gct?gag?gca?ggc?gat?atc?ttt?aag?gcg?ttc?atc?aat 211

Gly?Thr?Glu?Leu?Ala?Glu?Ala?Gly?Asp?Ile?Phe?Lys?Ala?Phe?Ile?Asn

25 30 35

tct?ggt?ggc?acg?ctt?atc?gac?gtc?tcc?ccc?aac?tac?acc?acc?ggc?gtc 259

Ser?Gly?Gly?Thr?Leu?Ile?Asp?Val?Ser?Pro?Asn?Tyr?Thr?Thr?Gly?Val

40 45 50

gcg?gaa?gaa?atg?ctc?ggc?acg?atg?ttg?gat?gcg?gaa?gtc?tct?cgt?tcg 307

Ala?Glu?Glu?Met?Leu?Gly?Thr?Met?Leu?Asp?Ala?Glu?Val?Ser?Arg?Ser

55 60 65

gct?gtc?gtc?att?tcc?tcc?agc?gca?ggt?gtc?aac?ccc?gct?ctg?ccg?ctc 355

Ala?Val?Val?Ile?Ser?Ser?Ser?Ala?Gly?Val?Asn?Pro?Ala?Leu?Pro?Leu

70 75 80 85

ggc?cga?cgt?gtg?gat?tgc?tcc?cgc?cgc?aat?ttg?att?gcc?caa?tta?gat 403

Gly?Arg?Arg?Val?Asp?Cys?Ser?Arg?Arg?Asn?Leu?Ile?Ala?Gln?Leu?Asp

90 95 100

gtc?acc?ctg?cgg?gca?tta?aac?act?gac?tat?ttg?gat?ttg?tgg?tct?gtg 451

Val?Thr?Leu?Arg?Ala?Leu?Asn?Thr?Asp?Tyr?Leu?Asp?Leu?Trp?Ser?Val

105 110 115

ggc?tat?tgg?gat?gag?ggc?acc?cca?ccg?cat?gag?gtg?gcc?gat?act?ttg 499

Gly?Tyr?Trp?Asp?Glu?Gly?Thr?Pro?Pro?His?Glu?Val?Ala?Asp?Thr?Leu

120 125 130

gat?tac?gcc?gtg?cgc?acc?ggc?cga?gtc?cga?tat?gcc?ggt?gtc?cga?gga 547

Asp?Tyr?Ala?Val?Arg?Thr?Gly?Arg?Val?Arg?Tyr?Ala?Gly?ValArg?Gly

135 140 145

tat?tcc?ggt?tgg?cag?tta?gcg?gtc?acc?cac?gct?gca?tcc?aat?cat?gca 595

Tyr?Ser?Gly?Trp?Gln?Leu?Ala?Val?Thr?His?Ala?Ala?Ser?Asn?His?Ala

150 155 160 165

gcg?gcc?tcc?gcc?cgc?ccc?gtg?gtc?gtt?gca?caa?aat?gaa?tac?agc?ctg 643

Ala?Ala?Ser?Ala?Arg?Pro?Val?Val?Val?Ala?Gln?Asn?Glu?Tyr?Ser?Leu

170 175 180

ctg?gaa?cgc?cgc?gca?gaa?caa?gaa?ctc?ctc?cct?gcc?acc?caa?cac?cta 691

Leu?Glu?Arg?Arg?Ala?Glu?Gln?Glu?Leu?Leu?Pro?Ala?Thr?Gln?His?Leu

185 190 195

ggt?gtc?gga?ttc?ttt?gct?ggc?gct?ccg?ctg?ggg?caa?ggc?gtg?ctg?act 739

Gly?Val?Gly?Phe?Phe?Ala?Gly?Ala?Pro?Leu?Gly?Gln?Gly?Val?Leu?Thr

200 205 210

gct?aaa?tac?cgc?tcc?gaa?att?ccc?cat?gat?tcc?aga?gct?gca?tcc?aca 787

Ala?Lys?Tyr?Arg?Ser?Glu?Ile?Pro?His?Asp?Ser?Arg?Ala?Ala?Ser?Thr

215 220 225

gga?cgc?gac?gca?gaa?gtc?caa?agc?tac?cta?gat?aat?cga?ggc?cgc?atc 835

Gly?Arg?Asp?Ala?Glu?Val?Gln?Ser?Tyr?Leu?Asp?Asn?Arg?Gly?Arg?Ile

230 235 240 245

att?gtc?gat?gct?ctt?gat?act?gca?gcc?aaa?gga?tta?ggc?att?agc?ccc 883

Ile?Val?Asp?Ala?Leu?Asp?Thr?Ala?Ala?Lys?Gly?Leu?Gly?Ile?Ser?Pro

250 255 260

gct?gtc?aca?gcc?acc?acc?tgg?gtg?cgt?gat?cgt?ccc?gga?gtg?aca?gct 931

Ala?Val?Thr?Ala?Thr?Thr?Trp?Val?Arg?Asp?Arg?Pro?Gly?Val?Thr?Ala

265 270 275

gtc?atc?gtg?ggc?gct?cgc?aca?cat?gaa?cag?ctg?tca?cat?ctt?ctc?aag 979

Val?Ile?Val?Gly?Ala?Arg?Thr?His?Glu?Gln?Leu?Ser?His?Leu?Leu?Lys

280 285 290

gcg?gaa?tcg?gtg?act?ttg?cca?aca?cca?atc?aca?caa?gcc?ctt?gat?gat 1027

Ala?Glu?Ser?Val?Thr?Leu?Pro?Thr?Pro?Ile?Thr?Gln?Ala?Leu?Asp?Asp

295 300 305

gtc?tcc?ctg?tgacttggtc?caattacatt?cac 1059

Val?Ser?Leu

310

<210>752

<211>312

<212>PRT

＜213〉Corynebacterium glutamicum

<400>752

Met?Val?Gly?Ser?Ser?Gly?Leu?Arg?Val?Ser?Arg?Leu?Gly?Leu?Gly?Thr

1 5 10 15

Ser?Thr?Trp?Gly?Ser?Gly?Thr?Glu?Leu?Ala?Glu?Ala?Gly?Asp?Ile?Phe

20 25 30

Lys?Ala?Phe?Ile?Asn?Ser?Gly?Gly?Thr?Leu?Ile?Asp?Val?Ser?Pro?Asn

35 40 45

Tyr?Thr?Thr?Gly?Val?Ala?Glu?Glu?Met?Leu?Gly?Thr?Met?Leu?Asp?Ala

50 55 60

Glu?Val?Ser?Arg?Ser?Ala?Val?Val?Ile?Ser?Ser?Ser?Ala?Gly?Val?Asn

65 70 75 80

Pro?Ala?Leu?Pro?Leu?Gly?Arg?Arg?Val?Asp?Cys?Ser?Arg?Arg?Asn?Leu

85 90 95

Ile?Ala?Gln?Leu?Asp?Val?Thr?Leu?Arg?Ala?Leu?Asn?Thr?Asp?Tyr?Leu

100 105 110

Asp?Leu?Trp?Ser?Val?Gly?Tyr?Trp?Asp?Glu?Gly?Thr?Pro?Pro?His?Glu

115 120 125

Val?Ala?Asp?Thr?Leu?Asp?Tyr?Ala?Val?Arg?Thr?Gly?Arg?Val?Arg?Tyr

130 135 140

Ala?Gly?Val?Arg?Gly?Tyr?Ser?Gly?Trp?Gln?Leu?Ala?Val?Thr?His?Ala

145 150 155 160

Ala?Ser?Asn?His?Ala?Ala?Ala?Ser?Ala?Arg?Pro?Val?Val?Val?Ala?Gln

165 170 175

Asn?Glu?Tyr?Ser?Leu?Leu?Glu?Arg?Arg?Ala?Glu?Gln?Glu?Leu?Leu?Pro

180 185 190

Ala?Thr?Gln?His?Leu?Gly?Val?Gly?Phe?Phe?Ala?Gly?Ala?Pro?Leu?Gly

195 200 205

Gln?Gly?Val?Leu?Thr?Ala?Lys?Tyr?Arg?Ser?Glu?Ile?Pro?His?Asp?Ser

210 215 220

Arg?Ala?Ala?Ser?Thr?Gly?Arg?Asp?Ala?Glu?Val?Gln?Ser?Tyr?Leu?Asp

225 230 235 240

Asn?Arg?Gly?Arg?Ile?Ile?Val?Asp?Ala?Leu?Asp?Thr?Ala?Ala?Lys?Gly

245 250 255

Leu?Gly?Ile?Ser?Pro?Ala?Val?Thr?Ala?Thr?Thr?Trp?Val?Arg?Asp?Arg

260 265 270

Pro?Gly?Val?Thr?Ala?Val?Ile?Val?Gly?Ala?Arg?Thr?His?Glu?Gln?Leu

275 280 285

Ser?His?Leu?Leu?Lys?Ala?Glu?Ser?Val?Thr?Leu?Pro?Thr?Pro?Ile?Thr

290 295 300

Gln?Ala?Leu?Asp?Asp?Val?Ser?Leu

305 310

<210>753

<211>747

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(724)

<223>RXN02554

<400>753

gcttttgaag?tgtgtcgcgt?gtgcggactg?aaatagtttc?cgcttcaact?tggttgctaa?60

ggataggctc?cataaaaata?accaaaggcg?gaaaatttca?atg?tca?cac?act?aag 115

Met?Ser?His?Thr?Lys

1 5

cca?tcc?att?gcc?atc?ctc?ggt?gct?ggc?cga?gtg?ggt?tct?tca?ctt?gcc 163

Pro?Ser?Ile?Ala?Ile?Leu?Gly?Ala?Gly?Arg?Val?Gly?Ser?Ser?Leu?Ala

10 15 20

agg?tca?gcg?gtc?gcc?gca?ggc?tat?gag?gta?aag?gtt?gct?ggt?tca?ggt 211

Arg?Ser?Ala?Val?Ala?Ala?Gly?Tyr?Glu?Val?Lys?Val?Ala?Gly?Ser?Gly

25 30 35

gct?gtg?gac?aaa?atc?gct?ctt?acc?gct?gag?atc?ctt?atg?ccc?ggc?gcg 259

Ala?Val?Asp?Lys?Ile?Ala?Leu?Thr?Ala?Glu?Ile?Leu?Met?Pro?Gly?Ala

40 45 50

gtt?cca?agc?act?gct?gac?cag?gct?gta?aag?gat?gca?gat?att?gtg?ttc 307

Val?Pro?Ser?Thr?Ala?Asp?Gln?Ala?Val?Lys?Asp?Ala?Asp?Ile?Val?Phe

55 60 65

ttg?gct?gtt?ccc?ctg?cat?aaa?ttc?cgc?agt?gtc?aat?cca?gcc?act?tta 355

Leu?Ala?Val?Pro?Leu?His?Lys?Phe?Arg?Ser?Val?Asn?Pro?Ala?Thr?Leu

70 75 80 85

gag?ggc?aag?atc?gtt?att?gac?acg?atg?aac?cac?tgg?gtt?ccg?gtc?aat 403

Glu?Gly?Lys?Ile?Val?Ile?Asp?Thr?Met?Asn?His?Trp?Val?Pro?Val?Asn

90 95 100

ggt?gag?ttg?gag?gaa?att?gat?cag?gat?ccg?cgc?agc?act?tcg?gag?att 451

Gly?Glu?Leu?Glu?Glu?Ile?Asp?Gln?Asp?Pro?Arg?Ser?Thr?Ser?Glu?Ile

105 110 115

att?gcg?gag?ttt?ttc?gcg?gga?tca?acc?atg?gtg?aag?tct?ttt?aac?cac 499

Ile?Ala?Glu?Phe?Phe?Ala?Gly?Ser?Thr?Met?Val?Lys?Ser?Phe?Asn?His

120 125 130

att?ggt?tat?cac?gag?att?gag?cag?gat?gcg?ggt?acc?ggg?cgt?gcg?att 547

Ile?Gly?Tyr?His?Glu?Ile?Glu?Gln?Asp?Ala?Gly?Thr?Gly?Arg?Ala?Ile

135 140 145

gcg?tat?gcc?acg?gat?gat?gtg?gat?gca?ggt?gcc?cag?gtt?gca?cag?cta 595

Ala?Tyr?Ala?Thr?Asp?Asp?Val?Asp?Ala?Gly?Ala?Gln?Val?Ala?Gln?Leu

150 155 160 165

att?aag?agt?ttt?ggg?ttt?gtt?cct?tta?aat?att?ggc?gca?ttg?gaa?aac 643

Ile?Lys?Ser?Phe?Gly?Phe?Val?Pro?Leu?Asn?Ile?Gly?Ala?Leu?Glu?Asn

170 175 180

ggc?cgt?att?ctg?gaa?cct?ggc?caa?gaa?gct?ttc?ggc?gcg?cac?ctt?aat 691

Gly?Arg?Ile?Leu?Glu?Pro?Gly?Gln?Glu?Ala?Phe?Gly?Ala?His?Leu?Asn

185 190 195

aaa?gat?tcg?cgc?cta?gaa?ctt?gtt?aat?cag?cgg?tagtacctcg?atcttcagcc?744

Lys?Asp?Ser?Arg?Leu?Glu?Leu?Val?Asn?Gln?Arg

200 205

aac 747

<210>754

<211>208

<212>PRT

＜213〉Corynebacterium glutamicum

<400>754

Met?Ser?His?Thr?Lys?Pro?Ser?Ile?Ala?Ile?Leu?Gly?Ala?Gly?Arg?Val

1 5 10 15

Gly?Ser?Ser?Leu?Ala?Arg?Ser?Ala?Val?Ala?Ala?Gly?Tyr?Glu?Val?Lys

20 25 30

Val?Ala?Gly?Ser?Gly?Ala?Val?Asp?Lys?Ile?Ala?Leu?Thr?Ala?Glu?Ile

35 40 45

Leu?Met?Pro?Gly?Ala?Val?Pro?Ser?Thr?Ala?Asp?Gln?Ala?Val?Lys?Asp

50 55 60

Ala?Asp?Ile?Val?Phe?Leu?Ala?Val?Pro?Leu?His?Lys?Phe?Arg?Ser?Val

65 70 75 80

Asn?Pro?Ala?Thr?Leu?Glu?Gly?Lys?Ile?Val?Ile?Asp?Thr?Met?Asn?His

85 90 95

Trp?Val?Pro?Val?Asn?Gly?Glu?Leu?Glu?Glu?Ile?Asp?Gln?Asp?Pro?Arg

100 105 110

Ser?Thr?Ser?Glu?Ile?Ile?Ala?Glu?Phe?Phe?Ala?Gly?Ser?Thr?Met?Val

115 120 125

Lys?Ser?Phe?Asn?His?Ile?Gly?Tyr?His?Glu?Ile?Glu?Gln?Asp?Ala?Gly

130 135 140

Thr?Gly?Arg?Ala?Ile?Ala?Tyr?Ala?Thr?Asp?Asp?Val?Asp?Ala?Gly?Ala

145 150 155 160

Gln?Val?Ala?Gin?Leu?Ile?Lys?Ser?Phe?Gly?Phe?Val?Pro?Leu?Asn?Ile

165 170 175

Gly?Ala?Leu?Glu?Asn?Gly?Arg?Ile?Leu?Glu?Pro?Gly?Gln?Glu?Ala?Phe

180 185 190

Gly?Ala?His?Leu?Asn?Lys?Asp?Ser?Arg?Leu?Glu?Leu?Val?Asn?Gln?Arg

195 200 205

<210>755

<211>933

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(910)

<223>RXN01204

<400>755

ttacagcgag?tttttcagac?gtccatcgca?ccgtgcacaa?caacatttca?ggtgcacggc?60

ccgaacacgg?gagagaacgc?tgagcgttac?aacactgtcc?atg?aag?ggc?gaa?ttc 115

Met?Lys?Gly?Glu?Phe

1 5

cac?gcc?ccc?gat?ttg?gac?aaa?gaa?ttt?ttc?ccg?ggg?cac?gta?acc?gat 163

His?Ala?Pro?Asp?Leu?Asp?Lys?Glu?Phe?Phe?Pro?Gly?His?Val?Thr?Asp

10 15 20

agt?ggt?gaa?gtc?gtg?aac?atg?ctg?ttc?acc?gat?ttc?gct?aat?ggt?tgg 211

Ser?Gly?Glu?Val?Val?Asn?Met?Leu?Phe?Thr?Asp?Phe?Ala?Asn?Gly?Trp

25 30 35

ttc?gca?atg?gac?cgc?atc?gta?ttg?atc?cgt?ctt?ctt?atg?acg?gca?gtc 259

Phe?Ala?Met?Asp?Arg?Ile?Val?Leu?Ile?Arg?Leu?Leu?Met?Thr?Ala?Val

40 45 50

gtt?gtg?gtc?ttc?ttc?ctt?tgg?gct?atg?cgc?aag?cca?aag?ctt?gtt?ccg 307

Val?Val?Val?Phe?Phe?Leu?Trp?Ala?Met?Arg?Lys?Pro?Lys?Leu?Val?Pro

55 60 65

cat?ggc?gtc?cag?aat?ttt?gca?gag?tac?gca?ctc?gat?ttc?gtt?ggt?att 355

His?Gly?Val?Gln?Asn?Phe?Ala?Glu?Tyr?Ala?Leu?Asp?Phe?Val?Gly?Ile

70 75 80 85

cac?atc?gct?gaa?gac?atc?ctc?gga?aag?aag?aaa?ggt?cgt?cgg?ttc?ctg 403

His?Ile?Ala?Glu?Asp?Ile?Leu?Gly?Lys?Lys?Lys?Gly?Arg?Arg?Phe?Leu

90 95 100

ccg?atc?ctg?gcc?acc?atc?ttc?ttc?gcg?gct?ctg?ttg?atg?aac?ctt?gca 451

Pro?Ile?Leu?Ala?Thr?Ile?Phe?Phe?Ala?Ala?Leu?Leu?Met?Asn?Leu?Ala

105 110 115

acg?atc?atc?ccg?gga?cta?aac?atc?tcc?tcc?aac?tca?cgt?att?gca?ttc 499

Thr?Ile?Ile?Pro?Gly?Leu?Asn?Ile?Ser?Ser?Asn?Ser?Arg?Ile?Ala?Phe

120 125 130

cca?atc?gtg?atg?gcg?gta?gct?ggt?tac?atc?gcg?ttt?atc?tac?gca?ggc 547

Pro?Ile?Val?Met?Ala?Val?Ala?Gly?Tyr?Ile?Ala?Phe?Ile?Tyr?Ala?Gly

135 140 145

tct?aag?cgt?tac?gga?ttc?ttc?aaa?tat?gtg?aag?tct?tct?gtt?gtg?att 595

Ser?Lys?Arg?Tyr?Gly?Phe?Phe?Lys?Tyr?Val?Lys?Ser?Ser?Val?Val?Ile

150 155 160 165

ccg?aac?att?cca?cca?gca?ctt?cac?gtc?ttg?gtg?gtt?cca?att?gag?ttc 643

Pro?Asn?Ile?Pro?Pro?Ala?Leu?His?Val?Leu?Val?Val?Pro?Ile?Glu?Phe

170 175 180

ttc?tct?aca?ttc?atc?ttg?agg?cca?gtc?acc?ctg?gca?ctg?cgt?ttg?atg 691

Phe?Ser?Thr?Phe?Ile?Leu?Arg?Pro?Val?Thr?Leu?Ala?Leu?Arg?Leu?Met

185 190 195

gcc?aac?ttc?ctt?gct?ggc?cac?atc?atc?ctg?gtt?ctg?ctt?ttc?tcc?gca 739

Ala?Asn?Phe?Leu?Ala?Gly?His?Ile?Ile?Leu?Val?Leu?Leu?Phe?Ser?Ala

200 205 210

acg?aac?ttc?ttc?ttc?ttc?cag?ttc?aac?gga?tgg?aca?gca?atg?tcc?ggc 787

Thr?Asn?Phe?Phe?Phe?Phe?Gln?Phe?Asn?Gly?Trp?Thr?Ala?Met?Ser?Gly

215 220 225

gta?acc?atc?ttg?atg?gca?gta?ctc?ttc?acg?gtt?tac?gag?atc?att?gtt 835

Val?Thr?Ile?Leu?Met?Ala?Val?Leu?Phe?Thr?Val?Tyr?Glu?Ile?Ile?Val

230 235 240 245

atc?ttc?ctg?cag?gca?tac?atc?ttc?gct?ctg?ctg?gtc?gct?gta?tac?att 883

Ile?Phe?Leu?Gln?Ala?Tyr?Ile?Phe?Ala?Leu?Leu?Val?Ala?Val?Tyr?Ile

250 255 260

gag?ctt?tca?ctt?cac?gcg?gat?tct?cac?tagatgaaaa?aggtcgctat 930

Glu?Leu?Ser?Leu?His?Ala?Asp?Ser?His

265 270

taa 933

<210>756

<211>270

<212>PRT

＜213〉Corynebacterium glutamicum

<400>756

Met?Lys?Gly?Glu?Phe?His?Ala?Pro?Asp?Leu?Asp?Lys?Glu?Phe?Phe?Pro

1 5 10 15

Gly?His?Val?Thr?Asp?Ser?Gly?Glu?Val?Val?Asn?Met?Leu?Phe?Thr?Asp

20 25 30

Phe?Ala?Asn?Gly?Trp?Phe?Ala?Met?Asp?Arg?Ile?Val?Leu?Ile?Arg?Leu

35 40 45

Leu?Met?Thr?Ala?Val?Val?Val?Val?Phe?Phe?Leu?Trp?Ala?Met?Arg?Lys

50 55 60

Pro?Lys?Leu?Val?Pro?His?Gly?Val?Gln?Asn?Phe?Ala?Glu?Tyr?Ala?Leu

65 70 75 80

Asp?Phe?Val?Gly?Ile?His?Ile?Ala?Glu?Asp?Ile?Leu?Gly?Lys?Lys?Lys

85 90 95

Gly?Arg?Arg?Phe?Leu?Pro?Ile?Leu?Ala?Thr?Ile?Phe?Phe?Ala?Ala?Leu

100 105 110

Leu?Met?Asn?Leu?Ala?Thr?Ile?Ile?Pro?Gly?Leu?Asn?Ile?Ser?Ser?Asn

115 120 125

Ser?Arg?Ile?Ala?Phe?Pro?Ile?Val?Met?Ala?Val?Ala?Gly?Tyr?Ile?Ala

130 135 140

Phe?Ile?Tyr?Ala?Gly?Ser?Lys?Arg?Tyr?Gly?Phe?Phe?Lys?Tyr?Val?Lys

145 150 155 160

Ser?Ser?Val?Val?Ile?Pro?Asn?Ile?Pro?Pro?Ala?Leu?His?Val?Leu?Val

165 170 175

Val?Pro?Ile?Glu?Phe?Phe?Ser?Thr?Phe?Ile?Leu?Arg?Pro?Val?Thr?Leu

180 185 190

Ala?Leu?Arg?Leu?Met?Ala?Asn?Phe?Leu?Ala?Gly?His?Ile?Ile?Leu?Val

195 200 205

Leu?Leu?Phe?Ser?Ala?Thr?Asn?Phe?Phe?Phe?Phe?Gln?Phe?Asn?Gly?Trp

210 215 220

Thr?Ala?Met?Ser?Gly?Val?Thr?Ile?Leu?Met?Ala?Val?Leu?Phe?Thr?Val

225 230 235 240

Tyr?Glu?Ile?Ile?Val?Ile?Phe?Leu?Gln?Ala?Tyr?Ile?Phe?Ala?Leu?Leu

245 250 255

Val?Ala?Val?Tyr?Ile?Glu?Leu?Ser?Leu?His?Ala?Asp?Ser?His

260 265 270

<210>757

<211>862

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(862)

<223>FRXA01204

<400>757

ttacagcgag?tttttcagac?gtccatcgca?ccgtgcacaa?caacatttca?ggtgcacggc?60

ccgaacacgg?gagagaacgc?tgagcgttac?aacactgtcc?atg?aag?ggc?gaa?ttc 115

Met?Lys?Gly?Glu?Phe

1 5

cac?gcc?ccc?gat?ttg?gac?aaa?gaa?ttt?ttc?ccg?ggg?cac?gta?acc?gat 163

His?Ala?Pro?Asp?Leu?Asp?Lys?Glu?Phe?Phe?Pro?Gly?His?Val?Thr?Asp

10 15 20

agt?ggt?gaa?gtc?gtg?aac?atg?ctg?ttc?acc?gat?ttc?gct?aat?ggt?tgg 211

Ser?Gly?Glu?Val?Val?Asn?Met?Leu?Phe?Thr?Asp?Phe?Ala?Asn?Gly?Trp

25 30 35

ttc?gca?atg?gac?cgc?atc?gta?ttg?atc?cgt?ctt?ctt?atg?acg?gca?gtc 259

Phe?Ala?Met?Asp?Arg?Ile?Val?Leu?Ile?Arg?Leu?Leu?Met?Thr?Ala?Val

40 45 50

gtt?gtg?gtc?ttc?ttc?ctt?tgg?gct?atg?cgc?aag?cca?aag?ctt?gtt?ccg 307

Val?Val?Val?Phe?Phe?Leu?Trp?Ala?Met?Arg?Lys?Pro?Lys?Leu?Val?Pro

55 60 65

cat?ggc?gtc?cag?aat?ttt?gca?gag?tac?gca?ctc?gat?ttc?gtt?ggt?att 355

His?Gly?Val?Gln?Asn?Phe?Ala?Glu?Tyr?Ala?Leu?Asp?Phe?Val?Gly?Ile

70 75 80 85

cac?atc?gct?gaa?gac?atc?ctc?gga?aag?aag?aaa?ggt?cgt?cgg?ttc?ctg 403

His?Ile?Ala?Glu?Asp?Ile?Leu?Gly?Lys?Lys?Lys?Gly?Arg?Arg?Phe?Leu

90 95 100

ccg?atc?ctg?gcc?acc?atc?ttc?ttc?gcg?gct?ctg?ttg?atg?aac?ctt?gca 451

Pro?Ile?Leu?Ala?Thr?Ile?Phe?Phe?Ala?Ala?Leu?Leu?Met?Asn?Leu?Ala

105 110 115

acg?atc?atc?ccg?gga?cta?aac?atc?tcc?tcc?aac?tca?cgt?att?gca?ttc 499

Thr?Ile?Ile?Pro?Gly?Leu?Asn?Ile?Ser?Ser?Asn?Ser?Arg?Ile?Ala?Phe

120 125 130

cca?atc?gtg?atg?gcg?gta?gct?ggt?tac?atc?gcg?ttt?atc?tac?gca?ggc 547

Pro?Ile?Val?Met?Ala?Val?Ala?Gly?Tyr?Ile?Ala?Phe?Ile?Tyr?Ala?Gly

135 140 145

tct?aag?cgt?tac?gga?ttc?ttc?aaa?tat?gtg?aag?tct?tct?gtt?gtg?att 595

Ser?Lys?Arg?Tyr?Gly?Phe?Phe?Lys?Tyr?Val?Lys?Ser?Ser?Val?Val?Ile

150 155 160 165

ccg?aac?att?cca?cca?gca?ctt?cac?gtc?ttg?gtg?gtt?cca?att?gag?ttc 643

Pro?Asn?Ile?Pro?Pro?Ala?Leu?His?Val?Leu?Val?Val?Pro?Ile?Glu?Phe

170 175 180

ttc?tct?aca?ttc?atc?ttg?agg?cca?gtc?acc?ctg?gca?ctg?cgt?ttg?atg 691

Phe?Ser?Thr?Phe?Ile?Leu?Arg?Pro?Val?Thr?Leu?Ala?Leu?Arg?Leu?Met

185 190 195

gcc?aac?ttc?ctt?gct?ggc?cac?atc?atc?ctg?gtt?ctg?ctt?ttc?ttc?gca 739

Ala?Asn?Phe?Leu?Ala?Gly?His?Ile?Ile?Leu?Val?Leu?Leu?Phe?Phe?Ala

200 205 210

acg?aac?ttc?ttc?ttc?ttc?cag?ttc?aac?gga?tgg?aca?gca?atg?tcc?ggc 787

Thr?Asn?Phe?Phe?Phe?Phe?Gln?Phe?Asn?Gly?Trp?Thr?Ala?Met?Ser?Gly

215 220 225

gta?acc?atc?ttg?atg?gca?gta?ctc?ttc?acg?gtt?tac?gag?atc?att?gtt 835

Val?Thr?Ile?Leu?Met?Ala?Val?Leu?Phe?Thr?Val?Tyr?Glu?Ile?Ile?Val

230 235 240 245

atc?ttc?ctg?cag?gca?tac?atc?ttc?gct 862

Ile?Phe?Leu?Gln?Ala?Tyr?Ile?Phe?Ala

250

<210>758

<211>254

<212>PRT

＜213〉Corynebacterium glutamicum

<400>758

Met?Lys?Gly?Glu?Phe?His?Ala?Pro?Asp?Leu?Asp?Lys?Glu?Phe?Phe?Pro

1 5 10 15

Gly?His?Val?Thr?Asp?Ser?Gly?Glu?Val?Val?Asn?Met?Leu?Phe?Thr?Asp

20 25 30

Phe?Ala?Asn?Gly?Trp?Phe?Ala?Met?Asp?Arg?Ile?Val?Leu?Ile?Arg?Leu

35 40 45

Leu?Met?Thr?Ala?Val?Val?Val?Val?Phe?Phe?Leu?Trp?Ala?Met?Arg?Lys

50 55 60

Pro?Lys?Leu?Val?Pro?His?Gly?Val?Gln?Asn?Phe?Ala?Glu?Tyr?Ala?Leu

65 70 75 80

Asp?Phe?Val?Gly?Ile?His?Ile?Ala?Glu?Asp?Ile?Leu?Gly?Lys?Lys?Lys

85 90 95

Gly?Arg?Arg?Phe?Leu?Pro?Ile?Leu?Ala?Thr?Ile?Phe?Phe?Ala?Ala?Leu

100 105 110

Leu?Met?Asn?Leu?Ala?Thr?Ile?Ile?Pro?Gly?Leu?Asn?Ile?Ser?Ser?Asn

115 120 125

Ser?Arg?Ile?Ala?Phe?Pro?Ile?Val?Met?Ala?Val?Ala?Gly?Tyr?Ile?Ala

130 135 140

Phe?Ile?Tyr?Ala?Gly?Ser?Lys?Arg?Tyr?Gly?Phe?Phe?Lys?Tyr?Val?Lys

145 150 155 160

Set?Ser?Val?Val?Ile?Pro?Asn?Ile?Pro?Pro?Ala?Leu?His?Val?Leu?Val

165 170 175

Val?Pro?Ile?Glu?Phe?Phe?Ser?Thr?Phe?Ile?Leu?Arg?Pro?Val?Thr?Leu

180 185 190

Ala?Leu?Arg?Leu?Met?Ala?Asn?Phe?Leu?Ala?Gly?His?Ile?Ile?Leu?Val

195 200 205

Leu?Leu?Phe?Phe?Ala?Thr?Asn?Phe?Phe?Phe?Phe?Gln?Phe?Asn?Gly?Trp

210 215 220

Thr?Ala?Met?Ser?Gly?Val?Thr?Ile?Leu?Met?Ala?Val?Leu?Phe?Thr?Val

225 230 235 240

Tyr?Glu?Ile?Ile?Val?Ile?Phe?Leu?Gln?Ala?Tyr?Ile?Phe?Ala

245 250

<210>759

<211>1764

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1741)

<223>RXA01201

<400>759

tcgggcaaac?tcgagcgtct?gcgggcaagc?ttcgcataaa?gacacgacga?attagacaac?60

attagtaatg?ctggaagaaa?caaccgagag?caggaagaac?atg?gcg?gag?ctg?acg 115

Met?Ala?Glu?Leu?Thr

1 5

atc?tcc?tcc?gat?gag?atc?cgt?agc?gcg?att?gcg?aac?tac?acc?tcg?agc 163

Ile?Ser?Ser?Asp?Glu?Ile?Arg?Ser?Ala?Ile?Ala?Asn?Tyr?Thr?Ser?Ser

10 15 20

tac?tcc?gcg?gag?gcc?tcc?cgt?gag?gag?gtc?ggc?gtg?gtt?att?tcg?gcc 211

Tyr?Ser?Ala?Glu?Ala?Ser?Arg?Glu?Glu?Val?Gly?Val?Val?Ile?Ser?Ala

25 30 35

gct?gac?ggt?atc?gcc?cag?gtt?tcg?ggc?ctc?ccg?tca?gta?atg?gcg?aat 259

Ala?Asp?Gly?Ile?Ala?Gln?Val?Ser?Gly?Leu?Pro?Ser?Val?Met?Ala?Asn

40 45 50

gag?ctc?ctc?gaa?ttc?ccg?ggc?ggc?gtc?atc?ggc?gtc?gca?cag?aac?ctt 307

Glu?Leu?Leu?Glu?Phe?Pro?Gly?Gly?Val?Ile?Gly?Val?Ala?Gln?Asn?Leu

55 60 65

gaa?gct?gac?cga?gtc?ggc?gtc?gtg?gtc?ctg?ggt?aac?tac?gag?cta?ctt 355

Glu?Ala?Asp?Arg?Val?Gly?Val?Val?Val?Leu?Gly?Asn?Tyr?Glu?Leu?Leu

70 75 80 85

aaa?gaa?ggc?gac?caa?gtt?cgt?cgt?act?gga?gac?gtt?ctg?tct?atc?cca 403

Lys?Glu?Gly?Asp?Gln?Val?Arg?Arg?Thr?Gly?Asp?Val?Leu?Ser?Ile?Pro

90 95 100

gtc?ggc?gag?gca?ttc?ctt?ggc?cgc?gtt?atc?aac?ccc?ctt?ggc?cag?cca 451

Val?Gly?Glu?Ala?Phe?Leu?Gly?Arg?Val?Ile?Asn?Pro?Leu?Gly?Gln?Pro

105 110 115

att?gac?ggc?ctg?ggc?gaa?att?gca?tcc?gaa?gag?gac?cgc?gtc?ctc?gag 499

Ile?Asp?Gly?Leu?Gly?Glu?Ile?Ala?Ser?Glu?Glu?Asp?Arg?Val?Leu?Glu

120 125 130

ctt?cag?gca?cca?acc?gtg?ctt?gag?cgc?cag?cct?gtc?gag?gag?cct?ttg 547

Leu?Gln?Ala?Pro?Thr?Val?Leu?Glu?Arg?Gln?Pro?Val?Glu?Glu?Pro?Leu

135 140 145

gca?acc?ggc?atc?aag?gct?atc?gat?gca?atg?acc?cca?atc?ggc?cgc?ggt 595

Ala?Thr?Gly?Ile?Lys?Ala?Ile?Asp?Ala?Met?Thr?Pro?Ile?Gly?Arg?Gly

150 155 160 165

cag?cgt?cag?ctg?atc?att?ggt?gac?cgt?aag?act?ggc?aag?acc?gca?gtc 643

Gln?Arg?Gln?Leu?Ile?Ile?Gly?Asp?Arg?Lys?Thr?Gly?Lys?Thr?Ala?Val

170 175 180

tgt?gtc?gat?acc?atc?ctt?aac?cag?aag?gcc?aac?tgg?gag?acc?ggc?gac 691

Cys?Val?Asp?Thr?Ile?Leu?Asn?Gln?Lys?Ala?Asn?Trp?Glu?Thr?Gly?Asp

185 190 195

aag?acc?aag?cag?gtt?cgc?tgc?atc?tac?gtc?gca?atc?ggt?cag?aag?ggc 739

Lys?Thr?Lys?Gln?Val?Arg?Cys?Ile?Tyr?Val?Ala?Ile?Gly?Gln?Lys?Gly

200 205 210

tcc?acc?att?gca?gcc?ctg?cgt?aag?acc?ctc?gag?gag?cag?ggc?gct?ctc 787

Ser?Thr?Ile?Ala?Ala?Leu?Arg?Lys?Thr?Leu?Glu?Glu?Gln?Gly?Ala?Leu

215 220 225

gag?tac?acc?acc?atc?gtg?gct?gca?ccc?gct?tcc?gat?gct?gca?ggc?ttc 835

Glu?Tyr?Thr?Thr?Ile?Val?Ala?Ala?Pro?Ala?Ser?Asp?Ala?Ala?Gly?Phe

230 235 240 245

aag?tgg?ctt?gca?cca?ttc?gct?ggc?gct?gct?ctc?gcc?cag?cac?tgg?atg 883

Lys?Trp?Leu?Ala?Pro?Phe?Ala?Gly?Ala?Ala?Leu?Ala?Gln?His?Trp?Met

250 255 260

tac?cag?ggc?aac?cac?gtc?ctg?gtc?atc?tac?gat?gat?ctg?acc?aag?cag 931

Tyr?Gln?Gly?Asn?His?Val?Leu?Val?Ile?Tyr?Asp?Asp?Leu?Thr?Lys?Gln

265 270 275

gct?gag?gca?tac?cgt?gct?atc?tcc?ctg?ctg?ctg?cgt?cgc?cca?ccg?ggc 979

Ala?Glu?Ala?Tyr?Arg?Ala?Ile?Ser?Leu?Leu?Leu?Arg?Arg?Pro?Pro?Gly

280 285 290

cgc?gaa?gca?tac?cca?ggt?gac?gtc?ttc?tac?ctg?cac?tcc?cgt?ctg?ctg 1027

Arg?Glu?Ala?Tyr?Pro?Gly?Asp?Val?Phe?Tyr?Leu?His?Ser?Arg?Leu?Leu

295 300 305

gag?cgc?gct?gcg?aag?ctg?tcc?gat?gaa?cta?ggc?gca?ggt?tct?att?aca 1075

Glu?Arg?Ala?Ala?Lys?Leu?Ser?Asp?Glu?Leu?Gly?Ala?Gly?Ser?Ile?Thr

310 315 320 325

gca?ctg?cca?atc?att?gag?acc?aag?gct?aat?gac?gtt?tcc?gcc?ttc?att 1123

Ala?Leu?Pro?Ile?Ile?Glu?Thr?Lys?Ala?Asn?Asp?Val?Ser?Ala?Phe?Ile

330 335 340

cct?acc?aac?gtg?att?tcc?atc?acc?gac?ggt?cag?gta?ttc?ctt?gag?tcc 1171

Pro?Thr?Asn?Val?Ile?Ser?Ile?Thr?Asp?Gly?Gln?Val?Phe?Leu?Glu?Ser

345 350 355

gac?ctg?ttc?aac?cgt?ggc?gtt?cgc?ccg?gcg?atc?aac?gtc?ggt?gta?tcc 1219

Asp?Leu?Phe?Asn?Arg?Gly?Val?Arg?Pro?Ala?Ile?Asn?Val?Gly?Val?Ser

360 365 370

gtc?tcc?cgt?gtc?ggt?ggc?gca?gct?cag?acc?aag?ggt?atg?aag?aag?gtt 1267

Val?Ser?Arg?Val?Gly?Gly?Ala?Ala?Gln?Thr?Lys?Gly?Met?Lys?Lys?Val

375 380 385

gcc?ggt?tct?ctc?cgt?ctg?gat?ctg?gct?gca?ttc?cgc?gac?ctg?gaa?gca 1315

Ala?Gly?Ser?Leu?Arg?Leu?Asp?Leu?Ala?Ala?Phe?Arg?Asp?Leu?Glu?Ala

390 395 400 405

ttc?gct?acc?ttc?gca?tct?gac?ttg?gat?gct?gca?tcc?aag?tct?cag?ctt 1363

Phe?Ala?Thr?Phe?Ala?Ser?Asp?Leu?Asp?Ala?Ala?Ser?Lys?Ser?Gln?Leu

410 415 420

gag?cgt?ggc?cag?cgc?ctc?gtt?cag?ctg?ttg?att?cag?tct?gag?aac?gca 1411

Glu?Arg?Gly?Gln?Arg?Leu?Val?Gln?Leu?Leu?Ile?Gln?Ser?Glu?Asn?Ala

425 430 435

cct?cag?gct?gtt?gag?tac?cag?atc?att?tct?ctc?tgg?ctt?gca?ggc?gaa 1459

Pro?Gln?Ala?Val?Glu?Tyr?Gln?Ile?Ile?Ser?Leu?Trp?Leu?Ala?Gly?Glu

440 445 450

ggc?gca?ttc?gac?aac?gtt?cct?gtt?gaa?gat?gtt?cgt?cgc?ttc?gag?tcc 1507

Gly?Ala?Phe?Asp?Asn?Val?Pro?Val?Glu?Asp?Val?Arg?Arg?Phe?Glu?Ser

455 460 465

gaa?ctg?cac?gag?tac?tta?ggc?tcc?aac?gct?gca?cag?gtc?tac?gag?cag 1555

Glu?Leu?His?Glu?Tyr?Leu?Gly?Ser?Asn?Ala?Ala?Gln?Val?Tyr?Glu?Gln

470 475 480 485

atc?gct?ggt?gga?gct?cag?ctt?tcc?gac?gag?tcc?aag?gaa?acc?ttg?ctc 1603

Ile?Ala?Gly?Gly?Ala?Gln?Leu?Ser?Asp?Glu?Ser?Lys?Glu?Thr?Leu?Leu

490 495 500

aag?gca?acc?gaa?gat?ttc?aag?agc?gct?ttc?cag?acc?acc?gat?ggc?acc 1651

Lys?Ala?Thr?Glu?Asp?Phe?Lys?Ser?Ala?Phe?Gln?Thr?Thr?Asp?Gly?Thr

505 510 515

cct?gtc?atc?aac?gag?cct?gag?gtt?gaa?gca?ctc?gat?gca?ggc?cag?gtc 1699

Pro?Val?Ile?Asn?Glu?Pro?Glu?Val?Glu?Ala?Leu?Asp?Ala?Gly?Gln?Val

520 525 530

aag?aaa?gac?cag?ctc?acc?gtt?tcc?cgc?aag?gtc?agc?aag?aag 1741

Lys?Lys?Asp?Gln?Leu?Thr?Val?Ser?Arg?Lys?Val?Ser?Lys?Lys

535 540 545

taaggcagcg?agcctacact?aaa 1764

<210>760

<211>547

<212>PRT

＜213〉Corynebacterium glutamicum

<400>?760

Met?Ala?Glu?Leu?Thr?Ile?Ser?Ser?Asp?Glu?Ile?Arg?Ser?Ala?Ile?Ala

1 5 10 15

Asn?Tyr?Thr?Ser?Ser?Tyr?Ser?Ala?Glu?Ala?Ser?Arg?Glu?Glu?Val?Gly

20 25 30

Val?Val?Ile?Ser?Ala?Ala?Asp?Gly?Ile?Ala?Gln?Val?Ser?Gly?Leu?Pro

35 40 45

Ser?Val?Met?Ala?Asn?Glu?Leu?Leu?Glu?Phe?Pro?Gly?Gly?Val?Ile?Gly

50 55 60

Val?Ala?Gln?Asn?Leu?Glu?Ala?Asp?Arg?Val?Gly?Val?Val?Val?Leu?Gly

65 70 75 80

Asn?Tyr?Glu?Leu?Leu?Lys?Glu?Gly?Asp?Gln?Val?Arg?Arg?Thr?Gly?Asp

85 90 95

Val?Leu?Ser?Ile?Pro?Val?Gly?Glu?Ala?Phe?Leu?Gly?Arg?Val?Ile?Asn

100 105 110

Pro?Leu?Gly?Gln?Pro?Ile?Asp?Gly?Leu?Gly?Glu?Ile?Ala?Ser?Glu?Glu

115 120 125

Asp?Arg?Val?Leu?Glu?Leu?Gln?Ala?Pro?Thr?Val?Leu?Glu?Arg?Gln?Pro

130 135 140

Val?Glu?Glu?Pro?Leu?Ala?Thr?Gly?Ile?Lys?Ala?Ile?Asp?Ala?Met?Thr

145 150 155 160

Pro?Ile?Gly?Arg?Gly?Gln?Arg?Gln?Leu?Ile?Ile?Gly?Asp?Arg?Lys?Thr

165 170 175

Gly?Lys?Thr?Ala?Val?Cys?Val?Asp?Thr?Ile?Leu?Asn?Gln?Lys?Ala?Asn

180 185 190

Trp?Glu?Thr?Gly?Asp?Lys?Thr?Lys?Gln?Val?Arg?Cys?Ile?Tyr?Val?Ala

195 200 205

Ile?Gly?Gln?Lys?Gly?Ser?Thr?Ile?Ala?Ala?Leu?Arg?Lys?Thr?Leu?Glu

210 215 220

Glu?Gln?Gly?Ala?Leu?Glu?Tyr?Thr?Thr?Ile?Val?Ala?Ala?Pro?Ala?Ser

225 230 235 240

Asp?Ala?Ala?Gly?Phe?Lys?Trp?Leu?Ala?Pro?Phe?Ala?Gly?Ala?Ala?Leu

245 250 255

Ala?Gln?His?Trp?Met?Tyr?Gln?Gly?Asn?His?Val?Leu?Val?Ile?Tyr?Asp

260 265 270

Asp?Leu?Thr?Lys?Gln?Ala?Glu?Ala?Tyr?Arg?Ala?Ile?Ser?Leu?Leu?Leu

275 280 285

Arg?Arg?Pro?Pro?Gly?Arg?Glu?Ala?Tyr?Pro?Gly?Asp?Val?Phe?Tyr?Leu

290 295 300

His?Ser?Arg?Leu?Leu?Glu?Arg?Ala?Ala?Lys?Leu?Ser?Asp?Glu?Leu?Gly

305 310 315 320

Ala?Gly?Ser?Ile?Thr?Ala?Leu?Pro?Ile?Ile?Glu?Thr?Lys?Ala?Asn?Asp

325 330 335

Val?Ser?Ala?Phe?Ile?Pro?Thr?Asn?Val?Ile?Ser?Ile?Thr?Asp?Gly?Gln

340 345 350

Val?Phe?Leu?Glu?Ser?Asp?Leu?Phe?Asn?Arg?Gly?Val?Arg?Pro?Ala?Ile

355 360 365

Asn?Val?Gly?Val?Ser?Val?Ser?Arg?Val?Gly?Gly?Ala?Ala?Gln?Thr?Lys

370 375 380

Gly?Met?Lys?Lys?Val?Ala?Gly?Ser?Leu?Arg?Leu?Asp?Leu?Ala?Ala?Phe

385 390 395 400

Arg?Asp?Leu?Glu?Ala?Phe?Ala?Thr?Phe?Ala?Ser?Asp?Leu?Asp?Ala?Ala

405 410 415

Ser?Lys?Ser?Gln?Leu?Glu?Arg?Gly?Gln?Arg?Leu?Val?Gln?Leu?Leu?Ile

420 425 430

Gln?Ser?Glu?Asn?Ala?Pro?Gln?Ala?Val?Glu?Tyr?Gln?Ile?Ile?Ser?Leu

435 440 445

Trp?Leu?Ala?Gly?Glu?Gly?Ala?Phe?Asp?Asn?Val?Pro?Val?Glu?Asp?Val

450 455 460

Arg?Arg?Phe?Glu?Ser?Glu?Leu?His?Glu?Tyr?Leu?Gly?Ser?Asn?Ala?Ala

465 470 475 480

Gln?Val?Tyr?Glu?Gln?Ile?Ala?Gly?Gly?Ala?Gln?Leu?Ser?Asp?Glu?Ser

485 490 495

Lys?Glu?Thr?Leu?Leu?Lys?Ala?Thr?Glu?Asp?Phe?Lys?Ser?Ala?Phe?Gln

500 505 510

Thr?Thr?Asp?Gly?Thr?Pro?Val?Ile?Asn?Glu?Pro?Glu?Val?Glu?Ala?Leu

515 520 525

Asp?Ala?Gly?Gln?Val?Lys?Lys?Asp?Gln?Leu?Thr?Val?Ser?Arg?Lys?Val

530 535 540

Ser?Lys?Lys

545

<210>761

<211>1572

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..?(1549)

<223>RXN01193

<400>761

gtgtggccaa?ccaggcacgt?caggcacaga?tcacccagga?aatcacagag?attgttggtg?60

gcgcaggcgc?gctcgccgac?agcggagaaa?gtgactaatt?atg?act?aca?gct?ctt 115

Met?Thr?Thr?Ala?Leu

1 5

gaa?gag?cag?aac?gca?cag?cag?gca?gcc?act?gcc?ggc?cgt?gtc?gtg?cgt 163

Glu?Glu?Gln?Asn?Ala?Gln?Gln?Ala?Ala?Thr?Ala?Gly?Arg?Val?Val?Arg

10 15 20

gtc?att?ggt?gcg?gtc?gtc?gac?gtg?gag?ttt?ccc?cgc?ggc?gag?ctg?cca 211

Val?Ile?Gly?Ala?Val?Val?Asp?Val?Glu?Phe?Pro?Arg?Gly?Glu?Leu?Pro

25 30 35

gca?ctg?tac?aac?gca?ctt?act?gta?gag?gta?acc?ctc?gaa?tca?gtt?aag 259

Ala?Leu?Tyr?Asn?Ala?Leu?Thr?Val?Glu?Val?Thr?Leu?Glu?Ser?Val?Lys

40 45 50

aag?acc?gtt?gtt?ctc?gag?gtt?gct?cag?cac?ctc?ggc?gac?aac?ctc?atc 307

Lys?Thr?Val?Val?Leu?Glu?Val?Ala?Gln?His?Leu?Gly?Asp?Asn?Leu?Ile

55 60 65

cgc?acc?atc?gct?atg?gca?cca?acc?gac?gga?ctt?gtc?cgc?ggt?gct?gct 355

Arg?Thr?Ile?Ala?Met?Ala?Pro?Thr?Asp?Gly?Leu?Val?Arg?Gly?Ala?Ala

70 75 80 85

gta?acc?gat?act?gca?cgc?cca?att?tcc?gta?cca?gtg?ggc?gat?gtt?gtt 403

Val?Thr?Asp?Thr?Ala?Arg?Pro?Ile?Ser?Val?Pro?Val?Gly?Asp?Val?Val

90 95 100

aag?ggc?cac?gta?ttc?aac?gct?ttg?ggc?gac?tgc?cta?gac?gac?gtt?tcc 451

Lys?Gly?His?Val?Phe?Asn?Ala?Leu?Gly?Asp?Cys?Leu?Asp?Asp?Val?Ser

105 110 115

ctg?aac?aac?aac?cca?gag?atc?gag?cgt?tgg?ggc?atc?cac?cgc?gag?cca 499

Leu?Asn?Asn?Asn?Pro?Glu?Ile?Glu?Arg?Trp?Gly?Ile?His?Arg?Glu?Pro

120 125 130

cca?tca?ttc?gat?cag?ctt?gag?ggt?aag?acc?gag?atc?ctg?gaa?aca?ggc 547

Pro?Ser?Phe?Asp?Gln?Leu?Glu?Gly?Lys?Thr?Glu?Ile?Leu?Glu?Thr?Gly

135 140 145

atc?aag?gtt?atc?gac?ctt?ctc?acc?cct?tac?gtt?aag?ggt?gga?aag?atc 595

Ile?Lys?Val?Ile?Asp?Leu?Leu?Thr?Pro?Tyr?Val?Lys?Gly?Gly?Lys?Ile

150 155 160 165

ggc?ctc?ttc?ggt?ggt?gca?ggt?gtg?ggt?aag?acc?gtt?ctt?atc?cag?gaa 643

Gly?Leu?Phe?Gly?Gly?Ala?Gly?Val?Gly?Lys?Thr?Val?Leu?Ile?Gln?Glu

170 175 180

atg?atc?acc?cgt?att?gca?cgt?gag?ttc?tcc?ggt?act?tcc?gtg?ttc?gca 691

Met?Ile?Thr?Arg?Ile?Ala?Arg?Glu?Phe?Ser?Gly?Thr?Ser?Val?Phe?Ala

185 190 195

ggt?gtt?ggt?gag?cgt?acc?cgt?gag?ggc?acc?gac?ctc?ttc?ctc?gaa?atg 739

Gly?Val?Gly?Glu?Arg?Thr?Arg?Glu?Gly?Thr?Asp?Leu?Phe?Leu?Glu?Met

200 205 210

gaa?gaa?atg?ggc?gtt?ctc?cag?gac?acc?gcc?ctg?gtg?ttc?ggt?cag?atg 787

Glu?Glu?Met?Gly?Val?Leu?Gln?Asp?Thr?Ala?Leu?Val?Phe?Gly?Gln?Met

215 220 225

gat?gag?cca?cca?gga?gtc?ggt?atg?cgc?gtg?gct?ctg?tcc?ggc?ctg?acc 835

Asp?Glu?Pro?Pro?Gly?Val?Gly?Met?Arg?Val?Ala?Leu?Ser?Gly?Leu?Thr

230 235 240 245

atg?gcg?gag?tac?ttc?cgc?gat?gtt?cag?aac?cag?gac?gtg?ctg?ctg?ttc 883

Met?Ala?Glu?Tyr?Phe?Arg?Asp?Val?Gln?Asn?Gln?Asp?Val?Leu?Leu?Phe

250 255 260

atc?gac?aac?atc?ttc?cgt?ttc?acc?cag?gca?ggt?tct?gag?gtt?tcc?acc 931

Ile?Asp?Asn?Ile?Phe?Arg?Phe?Thr?Gln?Ala?Gly?Ser?Glu?Val?Ser?Thr

265 270 275

ctt?ctg?ggt?cgt?atg?cct?tcc?gcc?gtg?ggt?tac?cag?cca?acc?ctg?gct 979

Leu?Leu?Gly?Arg?Met?Pro?Ser?Ala?Val?Gly?Tyr?Gln?Pro?Thr?Leu?Ala

280 285 290

gac?gag?atg?ggt?gtt?ctc?cag?gag?cgc?att?acc?tcc?acc?aag?ggc?cgt 1027

Asp?Glu?Met?GIy?Val?Leu?Gln?Glu?Arg?Ile?Thr?Ser?Thr?Lys?Gly?Arg

295 300 305

tcg?att?acc?tct?ctg?cag?gcc?gtt?tac?gtt?cct?gcc?gat?gac?tac?acc 1075

Ser?Ile?Thr?Ser?Leu?Gln?Ala?Val?Tyr?Val?Pro?Ala?Asp?Asp?Tyr?Thr

310 315 320 325

gac?ccg?gct?cca?gcg?acc?acc?ttc?gct?cac?ttg?gat?gca?acc?acc?gag 1123

Asp?Pro?Ala?Pro?Ala?Thr?Thr?Phe?Ala?His?Leu?Asp?Ala?Thr?Thr?Glu

330 335 340

ctt?gac?cgc?tcc?att?gct?tcc?aag?ggt?att?tac?cca?gca?gtg?aac?cca 1171

Leu?Asp?Arg?Ser?Ile?Ala?Ser?Lys?Gly?Ile?Tyr?Pro?Ala?Val?Asn?Pro

345 350 355

ctg?acc?tcc?acc?tct?cgt?att?ctc?gag?cca?gca?atc?gtt?ggt?gag?cgt 1219

Leu?Thr?Ser?Thr?Ser?Arg?Ile?Leu?Glu?Pro?Ala?Ile?Val?Gly?Glu?Arg

360 365 370

cac?tac?gag?gtt?tct?cag?cgt?gtc?atc?ggc?att?ctg?cag?aag?aac?aag 1267

His?Tyr?Glu?Val?Ser?Gln?Arg?Val?Ile?Gly?Ile?Leu?Gln?Lys?Asn?Lys

375 380 385

gaa?ctt?cag?gac?atc?atc?gcc?atc?ctt?ggt?atg?gac?gag?ctt?tct?gaa 1315

Glu?Leu?Gln?Asp?Ile?Ile?Ala?Ile?Leu?Gly?Met?Asp?Glu?Leu?Ser?Glu

390 395 400 405

gag?gac?aag?atc?acc?gtt?gca?cgt?gcg?cgt?cgc?atc?gag?cgc?ttc?ctg 1363

Glu?Asp?Lys?Ile?Thr?Val?Ala?Arg?Ala?Arg?Arg?Ile?Glu?Arg?Phe?Leu

410 415 420

ggt?cag?aac?ttc?ttc?gtt?gca?gag?aag?ttc?acc?ggt?ctt?cct?ggc?tcc 1411

Gly?Gln?Asn?Phe?Phe?Val?Ala?Glu?Lys?Phe?Thr?Gly?Leu?Pro?Gly?Ser

425 430 435

tac?gtg?cca?ctg?acc?gac?acc?gtc?gac?gct?ttc?gag?cgt?att?tgc?aac 1459

Tyr?Val?Pro?Leu?Thr?Asp?Thr?Val?Asp?Ala?Phe?Glu?Arg?Ile?Cys?Asn

440 445 450

ggc?gac?ttc?gac?cac?tac?cca?gag?cag?gct?ttc?aac?ggc?ctc?ggt?ggt 1507

Gly?Asp?Phe?Asp?His?Tyr?Pro?Glu?Gln?Ala?Phe?Asn?Gly?Leu?Gly?Gly

455 460 465

ttg?gac?gat?gtc?gaa?gct?gca?tac?aag?aag?ctg?acc?gga?aag 1549

Leu?Asp?Asp?Val?Glu?Ala?Ala?Tyr?Lys?Lys?Leu?Thr?Gly?Lys

470 475 480

taaggtagag?acacatggct?gaa 1572

<210>762

<211>483

<212>PRT

＜213〉Corynebacterium glutamicum

<400>762

Met?Thr?Thr?Ala?Leu?Glu?Glu?Gln?Asn?Ala?Gln?Gln?Ala?Ala?Thr?Ala

1 5 10 15

Gly?Arg?Val?Val?Arg?Val?Ile?Gly?Ala?Val?Val?Asp?Val?Glu?Phe?Pro

20 25 30

Arg?Gly?Glu?Leu?Pro?Ala?Leu?Tyr?Asn?Ala?Leu?Thr?Val?Glu?Val?Thr

35 40 45

Leu?Glu?Ser?Val?Lys?Lys?Thr?Val?Val?Leu?Glu?Val?Ala?Gln?His?Leu

50 55 60

Gly?Asp?Asn?Leu?Ile?Arg?Thr?Ile?Ala?Met?Ala?Pro?Thr?Asp?Gly?Leu

65 70 75 80

Val?Arg?Gly?Ala?Ala?Val?Thr?Asp?Thr?Ala?Arg?Pro?Ile?Ser?Val?Pro

85 90 95

Val?Gly?Asp?Val?Val?Lys?Gly?His?Val?Phe?Asn?Ala?Leu?Gly?Asp?Cys

100 105 110

Leu?Asp?Asp?Val?Ser?Leu?Asn?Asn?Asn?Pro?Glu?Ile?Glu?Arg?Trp?Gly

115 120 125

Ile?His?Arg?Glu?Pro?Pro?Ser?Phe?Asp?Gln?Leu?Glu?Gly?Lys?Thr?Glu

130 135 140

Ile?Leu?Glu?Thr?Gly?Ile?Lys?Val?Ile?Asp?Leu?Leu?Thr?Pro?Tyr?Val

145 150 155 160

Lys?Gly?Gly?Lys?Ile?Gly?Leu?Phe?Gly?Gly?Ala?Gly?Val?Gly?Lys?Thr

165 170 175

Val?Leu?Ile?Gln?Glu?Met?Ile?Thr?Arg?Ile?Ala?Arg?Glu?Phe?Ser?Gly

180 185 190

Thr?Ser?Val?Phe?Ala?Gly?Val?Gly?Glu?Arg?Thr?Arg?Glu?Gly?Thr?Asp

195 200 205

Leu?Phe?Leu?Glu?Met?Glu?Glu?Met?Gly?Val?Leu?Gln?Asp?Thr?Ala?Leu

210 215 220

Val?Phe?Gly?Gln?Met?Asp?Glu?Pro?Pro?Gly?Val?Gly?Met?Arg?Val?Ala

225 230 235 240

Leu?Ser?Gly?Leu?Thr?Met?Ala?Glu?Tyr?Phe?Arg?Asp?Val?Gln?Asn?Gln

245 250 255

Asp?Val?Leu?Leu?Phe?Ile?Asp?Asn?Ile?Phe?Arg?Phe?Thr?Gln?Ala?Gly

260 265 270

Ser?Glu?Val?Ser?Thr?Leu?Leu?Gly?Arg?Met?Pro?Ser?Ala?Val?Gly?Tyr

275 280 285

Gln?Pro?Thr?Leu?Ala?Asp?Glu?Met?Gly?Val?Leu?Gln?Glu?Arg?Ile?Thr

290 295 300

Ser?Thr?Lys?Gly?Arg?Ser?Ile?Thr?Ser?Leu?Gln?Ala?Val?Tyr?Val?Pro

305 310 315 320

Ala?Asp?Asp?Tyr?Thr?Asp?Pro?Ala?Pro?Ala?Thr?Thr?Phe?Ala?His?Leu

325 330 335

Asp?Ala?Thr?Thr?Glu?Leu?Asp?Arg?Ser?Ile?Ala?Ser?Lys?Gly?Ile?Tyr

340 345 350

Pro?Ala?Val?Asn?Pro?Leu?Thr?Ser?Thr?Ser?Arg?Ile?Leu?Glu?Pro?Ala

355 360 365

Ile?Val?Gly?Glu?Arg?His?Tyr?Glu?Val?Ser?Gln?Arg?Val?Ile?Gly?Ile

370 375 380

Leu?Gln?Lys?Asn?Lys?Glu?Leu?Gln?Asp?Ile?Ile?Ala?Ile?Leu?Gly?Met

385 390 395 400

Asp?Glu?Leu?Ser?Glu?Glu?Asp?Lys?Ile?Thr?Val?Ala?Arg?Ala?Arg?Arg

405 410 415

Ile?Glu?Arg?Phe?Leu?Gly?Gln?Asn?Phe?Phe?Val?Ala?Glu?Lys?Phe?Thr

420 425 430

Gly?Leu?Pro?Gly?Ser?Tyr?Val?Pro?Leu?Thr?Asp?Thr?Val?Asp?Ala?Phe

435 440 445

Glu?Arg?Ile?Cys?Asn?Gly?Asp?Phe?Asp?His?Tyr?Pro?Glu?Gln?Ala?Phe

450 455 460

Asn?Gly?Leu?Gly?Gly?Leu?Asp?Asp?Val?Glu?Ala?Ala?Tyr?Lys?Lys?Leu

465 470 475 480

Thr?Gly?Lys

<210>763

<211>778

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(15)..(755)

<223>FRXA01193

<400>763

caccaggagt?cggt?atg?cgc?gtg?gct?ctg?tcc?ggc?ctg?acc?atg?gcg?gag 50

Met?Arg?Val?Ala?Leu?Ser?Gly?Leu?Thr?Met?Ala?Glu

1 5 10

tac?ttc?cgc?gat?gtt?cag?aac?cag?gac?gtg?ctg?ctg?ttc?atc?gac?aac 98

Tyr?Phe?Arg?Asp?Val?Gln?Asn?Gln?Asp?Val?Leu?Leu?Phe?Ile?Asp?Asn

15 20 25

atc?ttc?cgt?ttc?acc?cag?gca?ggt?tct?gag?gtt?tcc?acc?ctt?ctg?ggt 146

Ile?Phe?Arg?Phe?Thr?Gln?Ala?Gly?Ser?Glu?Val?Ser?Thr?Leu?Leu?Gly

30 35 40

cgt?atg?cct?tcc?gcc?gtg?ggt?tac?cag?cca?acc?ctg?gct?gac?gag?atg 194

Arg?Met?Pro?Ser?Ala?Val?Gly?Tyr?Gln?Pro?Thr?Leu?Ala?Asp?Glu?Met

45 50 55 60

ggt?gtt?ctc?cag?gag?cgc?att?acc?tcc?acc?aag?ggc?cgt?tcg?att?acc 242

Gly?Val?Leu?Gln?Glu?Arg?Ile?Thr?Ser?Thr?Lys?Gly?Arg?Ser?Ile?Thr

65 70 75

tct?ctg?cag?gcc?gtt?tac?gtt?cct?gcc?gat?gac?tac?acc?gac?ccg?gct 290

Ser?Leu?Gln?Ala?Val?Tyr?Val?Pro?Ala?Asp?Asp?Tyr?Thr?Asp?Pro?Ala

80 85 90

cca?gcg?acc?acc?ttc?gct?cac?ttg?gat?gca?acc?acc?gag?ctt?gac?cgc 338

Pro?Ala?Thr?Thr?Phe?Ala?His?Leu?Asp?Ala?Thr?Thr?Glu?Leu?Asp?Arg

95 100 105

tcc?att?gct?tcc?aag?ggt?att?tac?cca?gca?gtg?aac?cca?ctg?acc?tcc 386

Ser?Ile?Ala?Ser?Lys?Gly?Ile?Tyr?Pro?Ala?Val?Asn?Pro?Leu?Thr?Ser

110 115 120

acc?tct?cgt?att?ctc?gag?cca?gca?atc?gtt?ggt?gag?cgt?cac?tac?gag 434

Thr?Ser?Arg?Ile?Leu?Glu?Pro?Ala?Ile?Val?Gly?Glu?Arg?His?Tyr?Glu

125 130 135 140

gtt?tct?cag?cgt?gtc?atc?ggc?att?ctg?cag?aag?aac?aag?gaa?ctt?cag 482

Val?Ser?Gln?Arg?Val?Ile?Gly?Ile?Leu?Gln?Lys?Asn?Lys?Glu?Leu?Gln

145 150 155

gac?atc?atc?gcc?atc?ctt?ggt?atg?gac?gag?ctt?tct?gaa?gag?gac?aag 530

Asp?Ile?Ile?Ala?Ile?Leu?Gly?Met?Asp?Glu?Leu?Ser?Glu?Glu?Asp?Lys

160 165 170

atc?acc?gtt?gca?cgt?gcg?cgt?cgc?atc?gag?cgc?ttc?ctg?ggt?cag?aac 578

Ile?Thr?Val?Ala?Arg?Ala?Arg?Arg?Ile?Glu?Arg?Phe?Leu?Gly?Gln?Asn

175 180 185

ttc?ttc?gtt?gca?gag?aag?ttc?acc?ggt?ctt?cct?ggc?tcc?tac?gtg?cca 626

Phe?Phe?Val?Ala?Glu?Lys?Phe?Thr?Gly?Leu?Pro?Gly?Ser?Tyr?Val?Pro

190 195 200

ctg?acc?gac?acc?gtc?gac?gct?ttc?gag?cgt?att?tgc?aac?ggc?gac?ttc 674

Leu?Thr?Asp?Thr?Val?Asp?Ala?Phe?Glu?Arg?Ile?Cys?Asn?Gly?Asp?Phe

205 210 215 220

gac?cac?tac?cca?gag?cag?gct?ttc?aac?ggc?ctc?ggt?ggt?ttg?gac?gat 722

Asp?His?Tyr?Pro?Glu?Gln?Ala?Phe?Asn?Gly?Leu?Gly?Gly?Leu?Asp?Asp

225 230 235

gtc?gaa?gct?gca?tac?aag?aag?ctg?acc?gga?aag?taaggtagag?acacatggct?775

Val?Glu?Ala?Ala?Tyr?Lys?Lys?Leu?Thr?Gly?Lys

240 245

gaa 778

<210>764

<211>247

<212>PRT

＜213〉Corynebacterium glutamicum

<400>764

Met?Arg?Val?Ala?Leu?Ser?Gly?Leu?Thr?Met?Ala?Glu?Tyr?Phe?Arg?Asp

1 5 10 15

Val?Gln?Asn?Gln?Asp?Val?Leu?Leu?Phe?Ile?Asp?Asn?Ile?Phe?Arg?Phe

20 25 30

Thr?Gln?Ala?Gly?Ser?Glu?Val?Ser?Thr?Leu?Leu?Gly?Arg?Met?Pro?Ser

35 40 45

Ala?Val?Gly?Tyr?Gln?Pro?Thr?Leu?Ala?Asp?Glu?Met?Gly?Val?Leu?Gln

50 55 60

Glu?Arg?Ile?Thr?Ser?Thr?Lys?Gly?Arg?Ser?Ile?Thr?Ser?Leu?Gln?Ala

65 70 75 80

Val?Tyr?Val?Pro?Ala?Asp?Asp?Tyr?Thr?Asp?Pro?Ala?Pro?Ala?Thr?Thr

85 90 95

Phe?Ala?His?Leu?Asp?Ala?Thr?Thr?Glu?Leu?Asp?Arg?Ser?Ile?Ala?Ser

100 105 110

Lys?Gly?Ile?Tyr?Pro?Ala?Val?Asn?Pro?Leu?Thr?Ser?Thr?Ser?Arg?Ile

115 120 125

Leu?Glu?Pro?Ala?Ile?Val?Gly?Glu?Arg?His?Tyr?Glu?Val?Ser?Gln?Arg

130 135 140

Val?Ile?Gly?Ile?Leu?Gln?Lys?Asn?Lys?Glu?Leu?Gln?Asp?Ile?Ile?Ala

145 150 155 160

Ile?Leu?Gly?Met?Asp?Glu?Leu?Ser?Glu?Glu?Asp?Lys?Ile?Thr?Val?Ala

165 170 175

Arg?Ala?Arg?Arg?Ile?Glu?Arg?Phe?Leu?Gly?Gln?Asn?Phe?Phe?Val?Ala

180 185 190

Glu?Lys?Phe?Thr?Gly?Leu?Pro?Gly?Ser?Tyr?Val?Pro?Leu?Thr?Asp?Thr

195 200 205

Val?Asp?Ala?Phe?Glu?Arg?Ile?Cys?Asn?Gly?Asp?Phe?Asp?His?Tyr?Pro

210 215 220

Glu?Gln?Ala?Phe?Asn?Gly?Leu?Gly?Gly?Leu?Asp?Asp?Val?Glu?Ala?Ala

225 230 235 240

Tyr?Lys?Lys?Leu?Thr?Gly?Lys

245

<210>765

<211>739

<212>DNA

＜212〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(739)

<223>FRXA01203

<400>765

gtgtggccaa?ccaggcacgt?caggcacaga?tcacccagga?aatcacagag?attgttggtg?60

gcgcaggcgc?gctcgccgac?agcggagaaa?gtgactaatt?atg?act?aca?gct?ctt 115

Met?Thr?Thr?Ala?Leu

1 5

gaa?gag?cag?aac?gca?cag?cag?gca?gcc?act?gcc?ggc?cgt?gtc?gtg?cgt 163

Glu?Glu?Gln?Asn?Ala?Gln?Gln?Ala?Ala?Thr?Ala?Gly?Arg?Val?Val?Arg

10 15 20

gtc?att?ggt?gcg?gtc?gtc?gac?gtg?gag?ttt?ccc?cgc?ggc?gag?ctg?cca 211

Val?Ile?Gly?Ala?Val?Val?Asp?Val?Glu?Phe?Pro?Arg?Gly?Glu?Leu?Pro

25 30 35

gca?ctg?tac?aac?gca?ctt?act?gta?gag?gta?acc?ctc?gaa?tca?gtt?aag 259

Ala?Leu?Tyr?Asn?Ala?Leu?Thr?Val?Glu?Val?Thr?Leu?Glu?Ser?Val?Lys

40 45 50

aag?acc?gtt?gtt?ctc?gag?gtt?gct?cag?cac?ctc?ggc?gac?aac?ctc?atc 307

Lys?Thr?Val?Val?Leu?Glu?Val?Ala?Gln?His?Leu?Gly?Asp?Asn?Leu?Ile

55 60 65

cgc?acc?atc?gct?atg?gca?cca?acc?gac?gga?ctt?gtc?cgc?ggt?gct?gct 355

Arg?Thr?Ile?Ala?Met?Ala?Pro?Thr?Asp?Gly?Leu?Val?Arg?Gly?Ala?Ala

70 75 80 85

gta?acc?gat?act?gca?cgc?cca?att?tcc?gta?cca?gtg?ggc?gat?gtt?gtt 403

Val?Thr?Asp?Thr?Ala?Arg?Pro?Ile?Ser?Val?Pro?Val?Gly?Asp?Val?Val

90 95 100

aag?ggc?cac?gta?ttc?aac?gct?ttg?ggc?gac?tgc?cta?gac?gac?gtt?tcc 451

Lys?Gly?His?Val?Phe?Asn?Ala?Leu?Gly?Asp?Cys?Leu?Asp?Asp?Val?Ser

105 110 115

ctg?aac?aac?aac?cca?gag?atc?gag?cgt?tgg?ggc?atc?cac?cgc?gag?cca 499

Leu?Asn?Asn?Asn?Pro?Glu?Ile?Glu?Arg?Trp?Gly?Ile?His?Arg?Glu?Pro

120 125 130

cca?tca?ttc?gat?cag?ctt?gag?ggt?aag?acc?gag?atc?ctg?gaa?aca?ggc 547

Pro?Ser?Phe?Asp?Gln?Leu?Glu?Gly?Lys?Thr?Glu?Ile?Leu?Glu?Thr?Gly

135 140 145

atc?aag?gtt?atc?gac?ctt?ctc?acc?cct?tac?gtt?aag?ggt?gga?aag?atc 595

Ile?Lys?Val?Ile?Asp?Leu?Leu?Thr?Pro?Tyr?Val?Lys?Gly?Gly?Lys?Ile

150 155 160 165

ggc?ctc?ttc?ggt?ggt?gca?ggt?gtg?ggt?aag?acc?gtt?ctt?atc?cag?gaa 643

Gly?Leu?Phe?Gly?Gly?Ala?Gly?Val?Gly?Lys?Thr?Val?Leu?Ile?Gln?Glu

170 175 180

atg?atc?acc?cgt?att?gca?cgt?gag?ttc?tcc?ggt?act?tcc?gtg?ttc?gca 691

Met?Ile?Thr?Arg?Ile?Ala?Arg?Glu?Phe?Ser?Gly?Thr?Ser?Val?Phe?Ala

185 190 195

ggt?gtt?ggt?aag?cgt?acc?cgt?gag?ggc?acc?gac?ctc?ttc?ctc?gaa?atg 739

Gly?Val?Gly?Lys?Arg?Thr?Arg?Glu?Gly?Thr?Asp?Leu?Phe?Leu?Glu?Met

200 205 210

<210>766

<211>213

<212>PRT

＜213〉Corynebacterium glutamicum

<400>766

Met?Thr?Thr?Ala?Leu?Glu?Glu?Gln?Asn?Ala?Gln?Gln?Ala?Ala?Thr?Ala

1 5 10 15

Gly?Arg?Val?Val?Arg?Val?Ile?Gly?Ala?Val?Val?Asp?Val?Glu?Phe?Pro

20 25 30

Arg?Gly?Glu?Leu?Pro?Ala?Leu?Tyr?Asn?Ala?Leu?Thr?Val?Glu?Val?Thr

35 40 45

Leu?Glu?Ser?Val?Lys?Lys?Thr?Val?Val?Leu?Glu?Val?Ala?Gln?His?Leu

50 55 60

Gly?Asp?Asn?Leu?Ile?Arg?Thr?Ile?Ala?Met?Ala?Pro?Thr?Asp?Gly?Leu

65 70 75 80

Val?Arg?Gly?Ala?Ala?Val?Thr?Asp?Thr?Ala?Arg?Pro?Ile?Ser?Val?Pro

85 90 95

Val?Gly?Asp?Val?Val?Lys?Gly?His?Val?Phe?Asn?Ala?Leu?Gly?Asp?Cys

100 105 110

Leu?Asp?Asp?Val?Ser?Leu?Asn?Asn?Asn?Pro?Glu?Ile?Glu?Arg?Trp?Gly

115 120 125

Ile?His?Arg?Glu?Pro?Pro?Ser?Phe?Asp?Gln?Leu?Glu?Gly?Lys?Thr?Glu

130 135 140

Ile?Leu?Glu?Thr?Gly?Ile?Lys?Val?Ile?Asp?Leu?Leu?Thr?Pro?Tyr?Val

145 150 155 160

Lys?Gly?Gly?Lys?Ile?Gly?Leu?Phe?Gly?Gly?Ala?Gly?Val?Gly?Lys?Thr

165 170 175

Val?Leu?Ile?Gln?Glu?Met?Ile?Thr?Arg?Ile?Ala?Arg?Glu?Phe?Ser?Gly

180 185 190

Thr?Ser?Val?Phe?Ala?Gly?Val?Gly?Lys?Arg?Thr?Arg?Glu?Gly?Thr?Asp

195 200 205

Leu?Phe?Leu?Glu?Met

210

<210>767

<211>363

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(340)

<223>RXN02821

<400>767

aagtcgccca?gatagcgagc?ggaccactcg?gtcaactgaa?taaccccact?aaacacttca?60

cagcccgaac?acacgggcac?cagaaaggga?acgacacctc?atg?aac?gag?atc?atc 115

Met?Asn?Glu?Ile?Ile

1 5

ctg?gca?cag?gac?gca?acc?gag?tcc?acc?atc?acc?gga?ctt?ggc?gct?gtc 163

Leu?Ala?Gln?Asp?Ala?Thr?Glu?Ser?Thr?Ile?Thr?Gly?Leu?Gly?Ala?Val

10 15 20

ggc?tac?ggc?atc?gca?acc?atc?gga?cct?ggc?ctc?ggc?atc?ggc?atc?ctg 211

Gly?Tyr?Gly?Ile?Ala?Thr?Ile?Gly?Pro?Gly?Leu?Gly?Ile?Gly?Ile?Leu

25 30 35

gtt?ggt?aag?gct?ctc?gag?ggt?atg?gca?cgt?cag?cct?gag?atg?gct?gga 259

Val?Gly?Lys?Ala?Leu?Glu?Gly?Met?Ala?Arg?Gln?Pro?Glu?Met?Ala?Gly

40 45 50

cag?ctc?cgt?acc?acc?atg?ttc?ctg?ggc?atc?gcc?ttc?gtt?gag?gcc?ctg 307

Gln?Leu?Arg?Thr?Thr?Met?Phe?Leu?Gly?Ile?Ala?Phe?Val?Glu?Ala?Leu

55 60 65

gca?ctg?atc?ggc?ctt?gtt?gct?ggc?ttc?ctg?ttc?taatcagcta?acttaaccga?360

Ala?Leu?Ile?Gly?Leu?Val?Ala?Gly?Phe?Leu?Phe

70 75 80

aag 363

<210>768

<211>80

<212>PRT

＜213〉Corynebacterium glutamicum

<400>768

Met?Asn?Glu?Ile?Ile?Leu?Ala?Gln?Asp?Ala?Thr?Glu?Ser?Thr?Ile?Thr

1 5 10 15

Gly?Leu?Gly?Ala?Val?GIy?Tyr?Gly?Ile?Ala?Thr?Ile?Gly?Pro?Gly?Leu

20 25 30

Gly?Ile?Gly?Ile?Leu?Val?Gly?Lys?Ala?Leu?Glu?Gly?Met?Ala?Arg?Gln

35 40 45

Pro?Glu?Met?Ala?Gly?Gln?Leu?Arg?Thr?Thr?Met?Phe?Leu?Gly?Ile?Ala

50 55 60

Phe?Val?Glu?Ala?Leu?Ala?Leu?Ile?Gly?Leu?Val?Ala?Gly?Phe?Leu?Phe

65 70 75 80

<210>769

<211>303

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(280)

<223>FRXA02821

<400>769

agcccgaaca?cacgggcacc?agaaagggaa?cgacacctca?tgaacgagat?catcttggca?60

caggacgcaa?ccgagtccac?catcaccgga?ccttggcgct?gtg?ggc?tac?ggc?atc 115

Val?Gly?Tyr?Gly?Ile

1 5

gca?acc?atc?gga?cct?ggc?ctc?ggc?atc?ggc?atc?ttg?gtt?ggt?aag?gct 163

Ala?Thr?Ile?Gly?Pro?Gly?Leu?Gly?Ile?Gly?Ile?Leu?Val?Gly?Lys?Ala

10 15 20

ctc?gag?ggt?atg?gca?cgt?cag?cct?gag?atg?gct?gga?cag?ctc?cgt?acc 211

Leu?Glu?Gly?Met?Ala?Arg?Gln?Pro?Glu?Met?Ala?Gly?Gln?Leu?Arg?Thr

25 30 35

acc?atg?ttc?ctg?ggc?atc?gcc?ttc?gtt?gag?gcc?ctg?gca?ctg?atc?ggc 259

Thr?Met?Phe?Leu?Gly?Ile?Ala?Phe?Val?Glu?Ala?Leu?Ala?Leu?Ile?Gly

40 45 50

ctt?gtt?gct?ggc?ttc?ctg?ttc?taatcagcta?acttaaccga?aag 303

Leu?Val?Ala?Gly?Phe?Leu?Phe

55 60

<210>770

<211>60

<212>PRT

＜213〉Corynebacterium glutamicum

<400>770

Val?Gly?Tyr?Gly?Ile?Ala?Thr?Ile?Gly?Pro?Gly?Leu?Gly?Ile?Gly?Ile

1 5 10 15

Leu?Val?Gly?Lys?Ala?Leu?Glu?Gly?Met?Ala?Arg?Gln?Pro?Glu?Met?Ala

20 25 30

Gly?Gln?Leu?Arg?Thr?Thr?Met?Phe?Leu?Gly?Ile?Ala?Phe?Val?Glu?Ala

35 40 45

Leu?Ala?Leu?Ile?Gly?Leu?Val?Ala?Gly?Phe?Leu?Phe

50 55 60

<210>771

<211>632

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(1)..(609)

<223>RXA01200

<400>771

ggc?tgt?ctt?cgg?tgg?aaa?agt?gag?cca?tct?gtt?ctc?gaa?gtc?ctc?aag 48

Gly?Cys?Leu?Arg?Trp?Lys?Ser?Glu?Pro?Ser?Val?Leu?Glu?Val?Leu?Lys

1 5 10 15

gac?gcc?gca?gag?cag?acc?tgg?tcc?act?cca?cgc?gag?ttc?cgc?gct?gga 96

Asp?Ala?Ala?Glu?Gln?Thr?Trp?Ser?Thr?Pro?Arg?Glu?Phe?Arg?Ala?Gly

20 25 30

cta?gtc?caa?ctt?ggc?cgt?cgc?gcc?ctt?ctt?cgc?tct?gcg?gag?aaa?cag 144

Leu?Val?Gln?Leu?Gly?Arg?Arg?Ala?Leu?Leu?Arg?Ser?Ala?Glu?Lys?Gln

35 40 45

ggt?cag?ctt?ggt?cag?gtg?gaa?gat?gaa?ctg?ttc?cga?ctc?agc?cga?atc 192

Gly?Gln?Leu?Gly?Gln?Val?Glu?Asp?Glu?Leu?Phe?Arg?Leu?Ser?Arg?Ile

50 55 60

ctg?gat?cgc?gaa?agc?aag?ctg?act?cag?ctt?ctt?tca?gat?cgc?act?cag 240

Leu?Asp?Arg?Glu?Ser?Lys?Leu?Thr?Gln?Leu?Leu?Ser?Asp?Arg?Thr?Gln

65 70 75 80

gaa?att?ggc?ggt?cga?cgt?gac?ctc?ctg?gct?aag?gtg?ctc?tac?ggc?aag 288

Glu?Ile?Gly?Gly?Arg?Arg?Asp?Leu?Leu?Ala?Lys?Val?Leu?Tyr?Gly?Lys

85 90 95

gta?act?gct?gtt?acc?gaa?gcc?ctc?gca?ctg?cag?gct?att?ggt?cgc?cct 336

Val?Thr?Ala?Val?Thr?Glu?Ala?Leu?Ala?Leu?Gln?Ala?Ile?Gly?Arg?Pro

100 105 110

gag?cac?aac?cca?att?gac?gat?atc?gca?gct?ttg?gct?ggc?gct?gta?gca 384

Glu?His?Asn?Pro?Ile?Asp?Asp?Ile?Ala?Ala?Leu?Ala?Gly?Ala?Val?Ala

115 120 125

gag?cta?cag?ggt?cgt?tcc?gtt?gca?cat?gtc?gtt?acc?gca?gtt?gaa?ctc 432

Glu?Leu?Gln?Gly?Arg?Ser?Val?Ala?His?Val?Val?Thr?Ala?Val?Glu?Leu

130 135 140

aac?gag?gga?cag?caa?caa?gcg?cta?gct?gaa?aag?ctg?gga?cgt?att?tat 480

Asn?Glu?Gly?Gln?Gln?Gln?Ala?Leu?Ala?Glu?Lys?Leu?Gly?Arg?Ile?Tyr

145 150 155 160

ggt?cgt?gcg?atg?agc?atc?cac?tcc?gag?gtt?gat?acc?agc?ctc?ctc?ggt 528

Gly?Arg?Ala?Met?Ser?Ile?His?Ser?Glu?Val?Asp?Thr?Ser?Leu?Leu?Gly

165 170 175

gga?atg?atc?atc?cgc?gtc?gga?gac?gaa?gta?att?gac?ggc?agc?acc?tcg 576

Gly?Met?Ile?Ile?Arg?Val?Gly?Asp?Glu?Val?Ile?Asp?Gly?Ser?Thr?Ser

180 185 190

ggc?aaa?ctc?gag?cgt?ctg?cgg?gca?agc?ttc?gca?taaagacacg?acgaattaga?629

Gly?Lys?Leu?Glu?Arg?Leu?Arg?Ala?Ser?Phe?Ala

195 200

caa 632

<210>772

<211>203

<212>PRT

＜213〉Corynebacterium glutamicum

<400>772

Gly?Cys?Leu?Arg?Trp?Lys?Ser?Glu?Pro?Ser?Val?Leu?Glu?Val?Leu?Lys

1 5 10 15

Asp?Ala?Ala?Glu?Gln?Thr?Trp?Ser?Thr?Pro?Arg?Glu?Phe?Arg?Ala?Gly

20 25 30

Leu?Val?Gln?Leu?Gly?Arg?Arg?Ala?Leu?Leu?Arg?Ser?Ala?Glu?Lys?Gln

35 40 45

Gly?Gln?Leu?Gly?Gln?Val?Glu?Asp?Glu?Leu?Phe?Arg?Leu?Ser?Arg?Ile

50 55 60

Leu?Asp?Arg?Glu?Ser?Lys?Leu?Thr?Gln?Leu?Leu?Ser?Asp?Arg?Thr?Gln

65 70 75 80

Glu?Ile?Gly?Gly?Arg?Arg?Asp?Leu?Leu?Ala?Lys?Val?Leu?Tyr?Gly?Lys

85 90 95

Val?Thr?Ala?Val?Thr?Glu?Ala?Leu?Ala?Leu?Gln?Ala?Ile?Gly?Arg?Pro

100 105 110

Glu?His?Asn?Pro?Ile?Asp?Asp?Ile?Ala?Ala?Leu?Ala?Gly?Ala?Val?Ala

115 120 125

Glu?Leu?Gln?Gly?Arg?Ser?Val?Ala?His?Val?Val?Thr?Ala?Val?Glu?Leu

130 135 140

Asn?Glu?Gly?Gln?Gln?Gln?Ala?Leu?Ala?Glu?Lys?Leu?Gly?Arg?Ile?Tyr

145 150 155 160

Gly?Arg?Ala?Met?Ser?Ile?His?Ser?Glu?Val?Asp?Thr?Ser?Leu?Leu?Gly

165 170 175

Gly?Met?Ile?Ile?Arg?Val?Gly?Asp?Glu?Val?Ile?Asp?Gly?Ser?Thr?Ser

180 185 190

Gly?Lys?Leu?Glu?Arg?Leu?Arg?Ala?Ser?Phe?Ala

195 200

<210>773

<211>495

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(472)

<223>RXA01194

<400>773

acttcgacca?ctacccagag?caggctttca?acggcctcgg?tggtttggac?gatgtcgaag?60

ctgcatacaa?gaagctgacc?ggaaagtaag?gtagagacac?atg?gct?gaa?atc?acc 115

Met?Ala?Glu?Ile?Thr

1 5

gtt?gaa?ctg?gtg?tct?gta?gag?cgc?atg?ctg?tgg?gcc?ggc?cag?gcc?tcc 163

Val?Glu?Leu?Val?Ser?Val?Glu?Arg?Met?Leu?Trp?Ala?Gly?Gln?Ala?Ser

10 15 20

atc?gtg?act?gca?cag?acc?acc?gag?ggt?gag?atc?ggc?gtg?ctg?ccc?gat 211

Ile?Val?Thr?Ala?Gln?Thr?Thr?Glu?Gly?Glu?Ile?Gly?Val?Leu?Pro?Asp

25 30 35

cac?gag?cct?ctt?ctc?ggc?caa?ttg?gtt?gag?aac?ggt?gtc?gtg?acc?atc 259

His?Glu?Pro?Leu?Leu?Gly?Gln?Leu?Val?Glu?Asn?Gly?Val?Val?Thr?Ile

40 45 50

cag?ccg?atc?gac?ggc?gaa?aag?ctt?atc?gcc?ggc?gtt?tcg?gat?gga?ttc 307

Gln?Pro?Ile?Asp?Gly?Glu?Lys?Leu?Ile?Ala?Gly?Val?Ser?Asp?Gly?Phe

55 60 65

ctc?tcc?gta?tct?aag?gaa?aag?gtg?acg?atc?ctc?gcg?gac?ttc?gcc?gtc 355

Leu?Ser?Val?Ser?Lys?Glu?Lys?Val?Thr?Ile?Leu?Ala?Asp?Phe?Ala?Val

70 75 80 85

tgg?gcg?aat?gag?gtt?gat?acc?gca?tcc?gcc?gag?gct?gac?ctt?aat?tcg 403

Trp?Ala?Asn?Glu?Val?Asp?Thr?Ala?Ser?Ala?Glu?Ala?Asp?Leu?Asn?Ser

90 95 100

gac?gac?gag?ctg?gcc?aag?gca?cac?gcc?gag?gct?ggg?ctg?cgc?gcg?gtc 451

Asp?Asp?Glu?Leu?Ala?Lys?Ala?His?Ala?Glu?Ala?Gly?Leu?Arg?Ala?Val

105 110 115

cgc?cgc?agc?agc?gaa?ggt?ctc?taaacctccg?tttagctgaa?gta 495

Arg?Arg?Ser?Ser?Glu?Gly?Leu

120

<210>774

<211>124

<212>PRT

＜213〉Corynebacterium glutamicum

<400>774

Met?Ala?Glu?Ile?Thr?Val?Glu?Leu?Val?Ser?Val?Glu?Arg?Met?Leu?Trp

1 5 10 15

Ala?Gly?Gln?Ala?Ser?Ile?Val?Thr?Ala?Gln?Thr?Thr?Glu?Gly?Glu?Ile

20 25 30

Gly?Val?Leu?Pro?Asp?His?Glu?Pro?Leu?Leu?Gly?Gln?Leu?Val?Glu?Asn

35 40 45

Gly?Val?Val?Thr?Ile?Gln?Pro?Ile?Asp?Gly?Glu?Lys?Leu?Ile?Ala?Gly

50 55 60

Val?Ser?Asp?Gly?Phe?Leu?Ser?Val?Ser?Lys?Glu?Lys?Val?Thr?Ile?Leu

65 70 75 80

Ala?Asp?Phe?Ala?Val?Trp?Ala?Asn?Glu?Val?Asp?Thr?Ala?Ser?Ala?Glu

85 90 95

Ala?Asp?Leu?Asn?Ser?Asp?Asp?Glu?Leu?Ala?Lys?Ala?His?Ala?Glu?Ala

100 105 110

Gly?Leu?Arg?Ala?Val?Arg?Arg?Ser?Ser?Glu?Gly?Leu

115 120

<210>775

<211>1098

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1075)

<223>RXA01202

<400>775

agaaagacca?gctcaccgtt?tcccgcaagg?tcagcaagaa?gtaaggcagc?gagcctacac?60

taaatgactg?tccaagcaac?tgaagggagg?cgtgtgaacc?atg?gca?aca?att?cgt 115

Met?Ala?Thr?Ile?Arg

1 5

gaa?ttg?cgt?gac?cga?att?cgt?tcg?gtt?aac?tca?acc?aag?aag?atc?acc 163

Glu?Leu?Arg?Asp?Arg?Ile?Arg?Ser?Val?Asn?Ser?Thr?Lys?Lys?Ile?Thr

10 15 20

aag?gct?caa?gag?ctc?atc?gcc?acc?tct?cgc?atc?acc?aag?gca?cag?ggt 211

Lys?Ala?Gln?Glu?Leu?Ile?Ala?Thr?Ser?Arg?Ile?Thr?Lys?Ala?Gln?Gly

25 30 35

cgc?gtc?gcg?gca?gct?gcg?ccg?tac?gcc?gag?gaa?atc?cag?cgc?gtg?ctg 259

Arg?Val?Ala?Ala?Ala?Ala?Pro?Tyr?Ala?Glu?Glu?Ile?Gln?Arg?Val?Leu

40 45 50

gag?cgc?ctc?gcg?tcg?gca?agc?tcc?cta?gac?cac?cca?atg?ctg?cgt?gag 307

Glu?Arg?Leu?Ala?Ser?Ala?Ser?Ser?Leu?Asp?His?Pro?Met?Leu?Arg?Glu

55 60 65

cgt?gaa?ggc?ggc?aag?cga?gcc?gcc?gtg?ctc?gtg?gtt?act?tct?gac?cgc 355

Arg?Glu?Gly?Gly?Lys?Arg?Ala?Ala?Val?Leu?Val?Val?Thr?Ser?Asp?Arg

70 75 80 85

ggc?atg?gct?ggt?ggc?tac?aac?cac?aac?gtt?ctg?aaa?aag?gca?gcg?gag 403

Gly?Met?Ala?Gly?Gly?Tyr?Asn?His?Asn?Val?Leu?Lys?Lys?Ala?Ala?Glu

90 95 100

ctg?gaa?aag?ctt?ctt?gct?gaa?agt?gga?tac?gaa?gtg?gtt?cgt?tat?gtc 451

Leu?Glu?Lys?Leu?Leu?Ala?Glu?Ser?Gly?Tyr?Glu?Val?Val?Arg?Tyr?Val

105 110 115

acc?ggc?aaa?aag?ggc?gtc?gac?tac?tac?aag?ttc?cgc?gct?gaa?gat?gtg 499

Thr?Gly?Lys?Lys?Gly?Val?Asp?Tyr?Tyr?Lys?Phe?Arg?Ala?Glu?Asp?Val

120 125 130

gct?ggc?acc?tgg?act?gga?ttc?tca?cag?gat?cca?gac?tgg?gca?gct?acc 547

Ala?Gly?Thr?Trp?Thr?Gly?Phe?Ser?Gln?Asp?Pro?Asp?Trp?Ala?Ala?Thr

135 140 145

cac?aac?gtg?cgc?cgt?cac?ctc?att?gat?ggt?ttc?acc?gcc?agc?tct?gaa 595

His?Asn?Val?Arg?Arg?His?Leu?Ile?Asp?Gly?Phe?Thr?Ala?Ser?Ser?Glu

150 155 160 165

ggt?gaa?gct?gca?tgg?cgc?gag?gga?ctg?aac?cta?cca?gaa?ggc?cag?gat 643

Gly?Glu?Ala?Ala?Trp?Arg?Glu?Gly?Leu?Asn?Leu?Pro?Glu?Gly?Gln?Asp

170 175 180

atc?cag?ggc?ttc?gac?cag?gtt?cac?gtg?gtc?tac?acc?gag?ttc?atc?tcc 691

Ile?Gln?Gly?Phe?Asp?Gln?Val?His?Val?Val?Tyr?Thr?Glu?Phe?Ile?Ser

185 190 195

atg?ctg?act?caa?aac?cca?gta?gtg?cac?caa?ctg?ctg?cct?gtt?gag?cca 739

Met?Leu?Thr?Gln?Asn?Pro?Val?Val?His?Gln?Leu?Leu?Pro?Val?Glu?Pro

200 205 210

gtc?atc?gaa?gat?gaa?att?ttc?gaa?aaa?ggc?gag?gat?ctg?ctg?tcc?tct 787

Val?Ile?Glu?Asp?Glu?Ile?Phe?Glu?Lys?Gly?Glu?Asp?Leu?Leu?Ser?Ser

215 220 225

tcc?ggc?gaa?gtc?gaa?ccc?gac?tac?gag?ttc?gag?ccg?gat?gca?gac?act 835

Ser?Gly?Glu?Val?Glu?Pro?Asp?Tyr?Glu?Phe?Glu?Pro?Asp?Ala?Asp?Thr

230 235 240 245

ctg?ctt?gag?gca?ctg?ctt?ccg?cag?tac?gtc?tct?cgt?agg?ctg?ttc?tcc 883

Leu?Leu?Glu?Ala?Leu?Leu?Pro?Gln?Tyr?Val?Ser?Arg?Arg?Leu?Phe?Ser

250 255 260

atc?ttc?ttg?gag?gct?gca?gct?gca?gag?tcc?gct?tca?cgt?cga?aac?gcg 931

Ile?Phe?Leu?Glu?Ala?Ala?Ala?Ala?Glu?Ser?Ala?Ser?Arg?Arg?Asn?Ala

265 270 275

atg?aag?tct?gcg?act?gac?aac?gct?acg?gaa?ctg?gtc?aag?gac?ctg?tcc 979

Met?Lys?Ser?Ala?Thr?Asp?Asn?Ala?Thr?Glu?Leu?Val?Lys?Asp?Leu?Ser

280 285 290

cgt?gtg?gcc?aac?cag?gca?cgt?cag?gca?cag?atc?acc?cag?gaa?atc?aca 1027

Arg?Val?Ala?Asn?Gln?Ala?Arg?Gln?Ala?Gln?Ile?Thr?Gln?Glu?Ile?Thr

295 300 305

gag?att?gtt?ggt?ggc?gca?ggc?gcg?ctc?gcc?gac?agc?gga?gaa?agt?gac 1075

Glu?Ile?Val?Gly?Gly?Ala?Gly?Ala?Leu?Ala?Asp?Ser?Gly?Glu?Ser?Asp

310 315 320 325

taattatgac?tacagctctt?gaa 1098

<210>776

<211>325

<212>PRT

＜213〉Corynebacterium glutamicum

<400>776

Met?Ala?Thr?Ile?Arg?Glu?Leu?Arg?Asp?Arg?Ile?Arg?Ser?Val?Asn?Ser

1 5 10 15

Thr?Lys?Lys?Ile?Thr?Lys?Ala?Gln?Glu?Leu?Ile?Ala?Thr?Ser?Arg?Ile

20 25 30

Thr?Lys?Ala?Gln?Gly?Arg?Val?Ala?Ala?Ala?Ala?Pro?Tyr?Ala?Glu?Glu

35 40 45

Ile?Gln?Arg?Val?Leu?Glu?Arg?Leu?Ala?Ser?Ala?Ser?Ser?Leu?Asp?His

50 55 60

Pro?Met?Leu?Arg?Glu?Arg?Glu?Gly?Gly?Lys?Arg?Ala?Ala?Val?Leu?Val

65 70 75 80

Val?Thr?Ser?Asp?Arg?Gly?Met?Ala?Gly?Gly?Tyr?Asn?His?Asn?Val?Leu

85 90 95

Lys?Lys?Ala?Ala?Glu?Leu?Glu?Lys?Leu?Leu?Ala?Glu?Ser?Gly?Tyr?Glu

100 105 110

Val?Val?Arg?Tyr?Val?Thr?Gly?Lys?Lys?Gly?Val?Asp?Tyr?Tyr?Lys?Phe

115 120 125

Arg?Ala?Glu?Asp?Val?Ala?Gly?Thr?Trp?Thr?Gly?Phe?Ser?Gln?Asp?Pro

130 135 140

Asp?Trp?Ala?Ala?Thr?His?Asn?Val?Arg?Arg?His?Leu?Ile?Asp?Gly?Phe

145 150 155 160

Thr?Ala?Ser?Ser?Glu?Gly?Glu?Ala?Ala?Trp?Arg?Glu?Gly?Leu?Asn?Leu

165 170 175

Pro?Glu?Gly?Gln?Asp?Ile?Gln?Gly?Phe?Asp?Gln?Val?His?Val?Val?Tyr

180 185 190

Thr?Glu?Phe?lle?Ser?Met?Leu?Thr?Gln?Asn?Pro?Val?Val?His?Gln?Leu

195 200 205

Leu?Pro?Val?Glu?Pro?Val?Ile?Glu?Asp?Glu?Ile?Phe?Glu?Lys?Gly?Glu

210 215 220

Asp?Leu?Leu?Ser?Ser?Ser?Gly?Glu?Val?Glu?Pro?Asp?Tyr?Glu?Phe?Glu

225 230 235 240

Pro?Asp?Ala?Asp?Thr?Leu?Leu?Glu?Ala?Leu?Leu?Pro?Gln?Tyr?Val?Ser

245 250 255

Arg?Arg?Leu?Phe?Ser?Ile?Phe?Leu?Glu?Ala?Ala?Ala?Ala?Glu?Ser?Ala

260 265 270

Ser?Arg?Arg?Asn?Ala?Met?Lys?Ser?Ala?Thr?Asp?Asn?Ala?Thr?Glu?Leu

275 280 285

Val?Lys?Asp?Leu?Ser?Arg?Val?Ala?Asn?Gln?Ala?Arg?Gln?Ala?Gln?Ile

290 295 300

Thr?Gln?Glu?Ile?Thr?Glu?Ile?Val?Gly?Gly?Ala?Gly?Ala?Leu?Ala?Asp

305 310 315 320

Ser?Gly?Glu?Ser?Asp

325

<210>777

<211>1773

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(1750)

<223>RXN02434

<400>777

cttcaatagt?caaaaccagc?aaactaattt?tttaagtttt?acgtaactgg?ccccaccgct?60

tgtggcaggc?cttgcgtttt?gacattgaag?gacccttttt?atg?cgc?act?ttt?gcc 115

Met?Arg?Thr?Phe?Ala

1 5

gct?tat?att?gcc?att?gat?ggc?ctc?agc?ttt?tcc?tac?ccc?aac?acc?cac 163

Ala?Tyr?Ile?Ala?Ile?Asp?Gly?Leu?Ser?Phe?Ser?Tyr?Pro?Asn?Thr?His

10 15 20

gtt?tta?agc?gat?att?tcg?ctc?acc?gtt?gcc?aat?ggc?gat?atc?gcc?gga 211

Val?Leu?Ser?Asp?Ile?Ser?Leu?Thr?Val?Ala?Asn?Gly?Asp?Ile?Ala?Gly

25 30 35

ctg?att?ggt?gaa?aac?ggc?gca?gga?aaa?tcc?acc?ctg?ctc?agc?ctc?atc 259

Leu?Ile?Gly?Glu?Asn?Gly?Ala?Gly?Lys?Ser?Thr?Leu?Leu?Ser?Leu?Ile

40 45 50

gct?ggc?gtc?atg?gaa?ccc?gac?cag?ggc?agg?att?tac?ctc?ccc?gaa?cgc 307

Ala?Gly?Val?Met?Glu?Pro?Asp?Gln?Gly?Arg?Ile?Tyr?Leu?Pro?Glu?Arg

55 60 65

acc?gga?ttc?atc?gcc?caa?gaa?aca?gac?tta?ccg?ttt?gaa?caa?ccc?gtg 355

Thr?Gly?Phe?Ile?Ala?Gln?Glu?Thr?Asp?Leu?Pro?Phe?Glu?Gln?Pro?Val

70 75 80 85

cag?tcg?ctt?atc?gac?gcc?gcc?gtc?gcc?cca?gtg?cgc?gcg?gtc?gat?gcc 403

Gln?Ser?Leu?Ile?Asp?Ala?Ala?Val?Ala?Pro?Val?Arg?Ala?Val?Asp?Ala

90 95 100

gcg?att?aca?gat?ttg?tcc?acc?aag?ctt?ggc?gac?gcc?tcc?ctc?agc?gcc 451

Ala?Ile?Thr?Asp?Leu?Ser?Thr?Lys?Leu?Gly?Asp?Ala?Ser?Leu?Ser?Ala

105 110 115

gaa?gag?cag?gcg?caa?gtc?gcc?aca?gat?ttc?gat?gca?gcg?cta?ggc?gct 499

Glu?Glu?Gln?Ala?Gln?Val?Ala?Thr?Asp?Phe?Asp?Ala?Ala?Leu?Gly?Ala

120 125 130

gca?gaa?gaa?ctc?gga?ctg?tgg?gaa?tta?gat?gca?cgt?att?gaa?acc?atc 547

Ala?Glu?Glu?Leu?Gly?Leu?Trp?Glu?Leu?Asp?Ala?Arg?Ile?Glu?Thr?Ile

135 140 145

gtc?gcg?ggt?ctc?ggc?ctt?gcc?gag?gtg?gat?cgc?agc?act?ccc?att?ggt 595

Val?Ala?Gly?Leu?Gly?Leu?Ala?Glu?Val?Asp?Arg?Ser?Thr?Pro?Ile?Gly

150 155 160 165

gag?ctt?tcc?ggc?ggt?cag?cgc?cgc?aga?ttc?gca?ttg?gca?gcg?ctg?ctg 643

Glu?Leu?Ser?Gly?Gly?Gln?Arg?Arg?Arg?Phe?Ala?Leu?Ala?Ala?Leu?Leu

170 175 180

ttg?gaa?cca?cac?gat?gct?ctg?att?ttc?gat?gag?ccc?acc?aac?cac?ctc 691

Leu?Glu?Pro?His?Asp?Ala?Leu?Ile?Phe?Asp?Glu?Pro?Thr?Asn?His?Leu

185 190 195

gac?gac?aca?gcc?gta?gat?ttc?ctc?atc?tcg?gag?att?tcc?cgt?ttc?aaa 739

Asp?Asp?Thr?Ala?Val?Asp?Phe?Leu?Ile?Ser?Glu?Ile?Ser?Arg?Phe?Lys

200 205 210

ggt?cca?gtg?ctg?atc?gcc?agc?cac?gat?cgc?ttc?ttc?ctc?gac?tcc?gtc 787

Gly?Pro?Val?Leu?Ile?Ala?Ser?His?Asp?Arg?Phe?Phe?Leu?Asp?Ser?Val

215 220 225

tgt?acc?gag?tta?atc?gac?ctc?gat?cct?gca?ctt?gga?cct?gag?ggc?gga 835

Cys?Thr?Glu?Leu?Ile?Asp?Leu?Asp?Pro?Ala?Leu?Gly?Pro?Glu?Gly?Gly

230 235 240 245

tcc?ggc?gaa?gaa?gta?aaa?caa?gcc?gtg?tct?ttt?ggt?ggt?gga?ttt?tct 883

Ser?Gly?Glu?Glu?Val?Lys?Gln?Ala?Val?Ser?Phe?Gly?Gly?Gly?Phe?Ser

250 255 260

gaa?tac?atc?aaa?gaa?cgc?gag?acc?cgc?cgc?acc?cgc?tgg?gct?cag?ttg 931

Glu?Tyr?Ile?Lys?Glu?Arg?Glu?Thr?Arg?Arg?Thr?Arg?Trp?Ala?Gln?Leu

265 270 275

tac?acc?gca?caa?gaa?acc?gag?cgg?gaa?aaa?ctc?gaa?gaa?acc?acc?ggc 979

Tyr?Thr?Ala?Gln?Glu?Thr?Glu?Arg?Glu?Lys?Leu?Glu?Glu?Thr?Thr?Gly

280 285 290

acc?acc?gaa?tcg?gat?att?ttc?cac?agc?tcg?gtt?tcc?aaa?tcg?gaa?gct 1027

Thr?Thr?Glu?Ser?Asp?Ile?Phe?His?Ser?Ser?Val?Ser?Lys?Ser?Glu?Ala

295 300 305

aaa?atc?acc?gcg?aaa?ttt?tac?gca?gac?cgg?gca?gct?aaa?act?caa?ggc 1075

Lys?Ile?Thr?Ala?Lys?Phe?Tyr?Ala?Asp?Arg?Ala?Ala?Lys?Thr?Gln?Gly

310 315 320 325

aac?cgc?gtc?cgc?tcc?gcc?aaa?aac?cgc?ctg?aag?gaa?ttg?gaa?cgc?tat 1123

Asn?Arg?Val?Arg?Ser?Ala?Lys?Asn?Arg?Leu?Lys?Glu?Leu?Glu?Arg?Tyr

330 335 340

gaa?atc?cca?gca?cct?cca?aag?cca?ctg?gaa?ttc?caa?ggc?atc?cca?gaa 1171

Glu?Ile?Pro?Ala?Pro?Pro?Lys?Pro?Leu?Glu?Phe?Gln?Gly?Ile?Pro?Glu

345 350 355

gcc?tcc?gga?aac?ggt?cac?ggt?gaa?aca?cta?gaa?gtg?cgg?gct?att?gct 1219

Ala?Ser?Gly?Asn?Gly?His?Gly?Glu?Thr?Leu?Glu?Val?Arg?Ala?Ile?Ala

360 365 370

gtg?gaa?aac?agg?ctt?caa?ccc?ttg?act?ttc?cac?atc?gat?ccc?ggc?gac 1267

Val?Glu?Asn?Arg?Leu?Gln?Pro?Leu?Thr?Phe?His?Ile?Asp?Pro?Gly?Asp

375 380 385

cac?atc?ctg?gtc?gaa?ggc?ccc?aac?ggt?gtc?ggt?aaa?tcc?acc?ctg?ctg 1315

His?Ile?Leu?Val?Glu?Gly?Pro?Asn?Gly?Val?Gly?Lys?Ser?Thr?Leu?Leu

390 395 400 405

agc?gtt?ctg?gaa?ggc?gtg?ctt?gaa?cca?acc?gaa?ggt?gaa?ttg?atc?gtc 1363

Ser?Val?Leu?Glu?Gly?Val?Leu?Glu?Pro?Thr?Glu?Gly?Glu?Leu?Ile?Val

410 415 420

ccc?gaa?ggg?ctg?aaa?gtt?gcg?cgc?ctg?aaa?cag?gac?gat?cag?tgg?acg 1411

Pro?Glu?Gly?Leu?Lys?Val?Ala?Arg?Leu?Lys?Gln?Asp?Asp?Gln?Trp?Thr

425 430 435

gaa?aag?cag?ttg?aac?acc?ccc?gtc?gac?gaa?ctg?ttc?gcc?gcc?cta?tcg 1459

Glu?Lys?Gln?Leu?Asn?Thr?Pro?Val?Asp?Glu?Leu?Phe?Ala?Ala?Leu?Ser

440 445 450

aaa?ggt?ccg?gtc?gga?ctc?aac?ctc?gtg?gag?atg?ggg?ctg?ttg?agg?gag 1507

Lys?Gly?Pro?Val?Gly?Leu?Asn?Leu?Val?Glu?Met?Gly?Leu?Leu?Arg?Glu

455 460 465

acg?tcg?caa?agc?agc?ccg?cta?cgg?gcc?cta?tcg?ctc?ggc?caa?cgc?cgg 1555

Thr?Ser?Gln?Ser?Ser?Pro?Leu?Arg?Ala?Leu?Ser?Leu?Gly?Gln?Arg?Arg

470 475 480 485

cgc?gtc?tcg?ctc?ggg?ctc?atc?ctg?gcg?agc?cca?cca?gat?ctt?ttg?ctt 1603

Arg?Val?Ser?Leu?Gly?Leu?Ile?Leu?Ala?Ser?Pro?Pro?Asp?Leu?Leu?Leu

490 495 500

ctt?gac?gag?ccc?acc?aac?cac?ctc?tcc?ctc?gcg?ctg?agc?gaa?gaa?ctc 1651

Leu?Asp?Glu?Pro?Thr?Asn?His?Leu?Ser?Leu?Ala?Leu?Ser?Glu?Glu?Leu

505 510 515

gag?tcg?gcg?ata?gaa?aaa?ttc?ccc?ggt?cgc?gtt?att?ctg?gcc?agc?cac 1699

Glu?Ser?Ala?Ile?Glu?Lys?Phe?Pro?Gly?Arg?Val?Ile?Leu?Ala?Ser?His

520 525 530

gat?agg?tgg?atc?aga?aaa?cgt?tgg?acg?ggg?aag?aaa?atc?agc?ctg?agc 1747

Asp?Arg?Trp?Ile?Arg?Lys?Arg?Trp?Thr?Gly?Lys?Lys?Ile?Ser?Leu?Ser

535 540 545

cgt?taaaccctac?tgaacaggaa?cct

Arg

550

<210>778

<211>550

<212>PRT

＜213〉Corynebacterium glutamicum

<400>778

Met?Arg?Thr?Phe?Ala?Ala?Tyr?Ile?Ala?Ile?Asp?Gly?Leu?Ser?Phe?Ser

1 5 10 15

Tyr?Pro?Asn?Thr?His?Val?Leu?Ser?Asp?Ile?Ser?Leu?Thr?Val?Ala?Asn

20 25 30

Gly?Asp?Ile?Ala?Gly?Leu?Ile?Gly?Glu?Asn?Gly?Ala?Gly?Lys?Ser?Thr

35 40 45

Leu?Leu?Ser?Leu?Ile?Ala?Gly?Val?Met?Glu?Pro?Asp?Gln?Gly?Arg?Ile

50 55 60

Tyr?Leu?Pro?Glu?Arg?Thr?Gly?Phe?Ile?Ala?Gln?Glu?Thr?Asp?Leu?Pro

65 70 75 80

Phe?Glu?Gln?Pro?Val?Gln?Ser?Leu?Ile?Asp?Ala?Ala?Val?Ala?Pro?Val

85 90 95

Arg?Ala?Val?Asp?Ala?Ala?Ile?Thr?Asp?Leu?Ser?Thr?Lys?Leu?Gly?Asp

100 105 110

Ala?Ser?Leu?Ser?Ala?Glu?Glu?Gln?Ala?Gln?Val?Ala?Thr?Asp?Phe?Asp

115 120 125

Ala?Ala?Leu?Gly?Ala?Ala?Glu?Glu?Leu?Gly?Leu?Trp?Glu?Leu?Asp?Ala

130 135 140

Arg?Ile?Glu?Thr?Ile?Val?Ala?Gly?Leu?Gly?Leu?Ala?Glu?Val?Asp?Arg

145 150 155 160

Ser?Thr?Pro?Ile?Gly?Glu?Leu?Ser?Gly?Gly?Gln?Arg?Arg?Arg?Phe?Ala

165 170 175

Leu?Ala?Ala?Leu?Leu?Leu?Glu?Pro?His?Asp?Ala?Leu?Ile?Phe?Asp?Glu

180 185 190

Pro?Thr?Asn?His?Leu?Asp?Asp?Thr?Ala?Val?Asp?Phe?Leu?Ile?Ser?Glu

195 200 205

Ile?Ser?Arg?Phe?Lys?Gly?Pro?Val?Leu?Ile?Ala?Ser?His?Asp?Arg?Phe

210 215 220

Phe?Leu?Asp?Ser?Val?Cys?Thr?Glu?Leu?Ile?Asp?Leu?Asp?Pro?Ala?Leu

225 230 235 240

Gly?Pro?Glu?Gly?Gly?Ser?Gly?Glu?Glu?Val?Lys?Gln?Ala?Val?Ser?Phe

245 250 255

Gly?Gly?Gly?Phe?Ser?Glu?Tyr?Ile?Lys?Glu?Arg?Glu?Thr?Arg?Arg?Thr

260 265 270

Arg?Trp?Ala?Gln?Leu?Tyr?Thr?Ala?Gln?Glu?Thr?Glu?Arg?Glu?Lys?Leu

275 280 285

Glu?Glu?Thr?Thr?Gly?Thr?Thr?Glu?Ser?Asp?Ile?Phe?His?Ser?Ser?Val

290 295 300

Ser?Lys?Ser?Glu?Ala?Lys?Ile?Thr?Ala?Lys?Phe?Tyr?Ala?Asp?Arg?Ala

305 310 315 320

Ala?Lys?Thr?Gln?Gly?Asn?Arg?Val?Arg?Ser?Ala?Lys?Asn?Arg?Leu?Lys

325 330 335

Glu?Leu?Glu?Arg?Tyr?Glu?Ile?Pro?Ala?Pro?Pro?Lys?Pro?Leu?Glu?Phe

340 345 350

Gln?Gly?Ile?Pro?Glu?Ala?Ser?Gly?Asn?Gly?His?Gly?Glu?Thr?Leu?Glu

355 360 365

Val?Arg?Ala?Ile?Ala?Val?Glu?Asn?Arg?Leu?Gln?Pro?Leu?Thr?Phe?His

370 375 380

Ile?Asp?Pro?Gly?Asp?His?Ile?Leu?Val?Glu?Gly?Pro?Asn?Gly?Val?Gly

385 390 395 400

Lys?Ser?Thr?Leu?Leu?Ser?Val?Leu?Glu?Gly?Val?Leu?Glu?Pro?Thr?Glu

405 410 415

Gly?Glu?eu?Ile?Val?Pro?Glu?Gly?Leu?Lys?Val?Ala?Arg?Leu?Lys?Gln

420 425 430

Asp?Asp?Gln?Trp?Thr?Glu?Lys?Gln?Leu?Asn?Thr?Pro?Val?Asp?Glu?Leu

435 440 445

Phe?Ala?Ala?Leu?Ser?Lys?Gly?Pro?Val?Gly?Leu?Asn?Leu?Val?Glu?Met

450 455 460

Gly?Leu?Leu?Arg?Glu?Thr?Ser?Gln?Ser?Ser?Pro?Leu?Arg?Ala?Leu?Ser

465 470 475 480

Leu?Gly?Gln?Arg?Arg?Arg?Val?Ser?Leu?Gly?Leu?Ile?Leu?Ala?Ser?Pro

485 490 495

Pro?Asp?Leu?Leu?Leu?Leu?Asp?Glu?Pro?Thr?Asn?His?Leu?Ser?Leu?Ala

500 505 510

Leu?Ser?Glu?Glu?Leu?Glu?Ser?Ala?Ile?Glu?Lys?Phe?Pro?Gly?Arg?Val

515 520 525

Ile?Leu?Ala?Ser?His?Asp?Arg?Trp?Ile?Arg?Lys?Arg?Trp?Thr?Gly?Lys

530 535 540

Lys?Ile?Ser?Leu?Ser?Arg

545 550

<210>779

<211>1407

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101）..(1384)

<223>RXN00684

<400>779

agtcacacct?aaaagtgata?gccatcacga?atctttagga?aaagtgattc?aaacttcact?60

gtgatcggct?tcggccacac?acaagtgtca?ggagatgaca?atg?act?tcc?cag?act 115

Met?Thr?Ser?Gln?Thr

1 5

tcc?caa?caa?tcc?acc?tca?acc?ggt?gga?tgc?cca?ttc?ggg?cac?aca?tca 163

Ser?Gln?Gln?Ser?Thr?Ser?Thr?Gly?Gly?Cys?Pro?Phe?Gly?His?Thr?Ser

10 15 20

gag?tcc?acc?agc?cat?cac?ggc?tac?cag?cct?ttc?gat?atg?cac?aac?ccg 211

Glu?Ser?Thr?Ser?His?His?Gly?Tyr?Gln?Pro?Phe?Asp?Met?His?Asn?Pro

25 30 35

ttt?cct?gca?tat?aaa?gaa?ctc?cgt?cag?gaa?gag?cca?gtg?atg?ttc?gat 259

Phe?Pro?Ala?Tyr?Lys?Glu?Leu?Arg?Gln?Glu?Glu?Pro?Val?Met?Phe?Asp

40 45 50

gag?cgc?atc?ggc?tac?tgg?gtg?gta?acc?aaa?tat?gac?gac?atc?aaa?acc 307

Glu?Arg?lle?Gly?Tyr?Trp?Val?Val?Thr?Lys?Tyr?Asp?Asp?Ile?Lys?Thr

55 60 65

acc?ttt?gat?gac?tgg?gaa?aca?ttc?tcc?tct?gaa?aat?gca?caa?gcc?cca 355

Thr?Phe?Asp?Asp?Trp?Glu?Thr?Phe?Ser?Ser?Glu?Asn?Ala?Gln?Ala?Pro

70 75 80 85

gtc?cgc?aag?cgt?gga?cct?cag?gca?acc?caa?atc?atg?acc?gat?ggc?ggc 403

Val?Arg?Lys?Arg?Gly?Pro?Gln?Ala?Thr?Gln?Ile?Met?Thr?Asp?Gly?Gly

90 95 100

ttc?act?gca?tac?tcc?gga?tta?tca?gct?cgt?att?cca?cca?gag?cac?acc 451

Phe?Thr?Ala?Tyr?Ser?Gly?Leu?Ser?Ala?Arg?Ile?Pro?Pro?Glu?His?Thr

105 110 115

cgc?atc?cgc?gca?atc?gca?caa?aag?gcc?ttc?acg?cca?cgc?cgc?tat?aaa 499

Arg?Ile?Arg?Ala?Ile?Ala?Gln?Lys?Ala?Phe?Thr?Pro?Arg?Arg?Tyr?Lys

120 125 130

gca?ctc?gaa?cca?gat?atc?cga?gca?atg?gtg?att?gat?cgt?gtg?gag?aaa 547

Ala?Leu?Glu?Pro?Asp?Ile?Arg?Ala?Met?Val?Ile?Asp?Arg?Val?Glu?Lys

135 140 145

atg?ttg?gcg?aat?gat?caa?cac?gtc?ggc?gat?atg?gtg?tca?gat?ctt?gcc 595

Met?Leu?Ala?Asn?Asp?Gln?His?Val?Gly?Asp?Met?Val?Ser?Asp?Leu?Ala

150 155 160 165

tac?gac?att?cca?acc?atc?acg?atc?ctg?acg?ctg?atc?ggt?gca?gat?att 643

Tyr?Asp?Ile?Pro?Thr?Ile?Thr?Ile?Leu?Thr?Leu?Ile?Gly?Ala?Asp?Ile

170 175 180

ttc?atg?gtg?gtc?acc?tac?aag?cgg?tgg?tca?gat?tcc?cgt?gcg?gcc?atg 691

Phe?Met?Val?Val?Thr?Tyr?Lys?Arg?Trp?Ser?Asp?Ser?Arg?Ala?Ala?Met

185 190 195

acc?tgg?ggc?gat?ctt?agt?gat?gaa?gag?cag?atc?cca?cac?gca?cac?aat 739

Thr?Trp?Gly?Asp?Leu?Ser?Asp?Glu?Glu?Gln?Ile?Pro?His?Ala?His?Asn

200 205 210

ttg?gtt?gag?tac?tgg?cag?gaa?tgc?caa?cgc?atg?gta?gct?gat?gca?cat 787

Leu?Val?Glu?Tyr?Trp?Gln?Glu?Cys?Gln?Arg?Met?Val?Ala?Asp?Ala?His

215 220 225

gca?cac?ggt?ggc?gac?aac?ctc?acc?gct?gat?cta?gtg?cga?gca?cag?caa 835

Ala?His?Gly?Gly?Asp?Asn?Leu?Thr?Ala?Asp?Leu?Val?Arg?Ala?Gln?Gln

230 235 240 245

gag?ggt?caa?gaa?atc?acc?gat?cat?gag?att?gct?tct?ttg?ctg?tac?tcc 883

Glu?Gly?Gln?Glu?Ile?Thr?Asp?His?Glu?Ile?Ala?Ser?Leu?Leu?Tyr?Ser

250 255 260

ctg?ctt?ttt?gcg?ggg?cac?gaa?aca?acc?acc?acg?ttg?atc?tcc?aat?tgt 931

Leu?Leu?Phe?Ala?Gly?His?Glu?Thr?Thr?Thr?Thr?Leu?Ile?Ser?Asn?Cys

265 270 275

ttc?cga?gtt?ctc?ctc?gat?cat?cca?gag?cag?tgg?caa?gcc?att?cta?gag 979

Phe?Arg?Val?Leu?Leu?Asp?His?Pro?Glu?Gln?Trp?Gln?Ala?Ile?Leu?Glu

280 285 290

aat?cca?aaa?ctg?att?cct?gcg?gca?gtg?gat?gag?gtc?ttg?cgg?tac?tcc 1027

Asn?Pro?Lys?Leu?Ile?Pro?Ala?Ala?Val?Asp?Glu?Val?Leu?Arg?Tyr?Ser

295 300 305

ggc?tcg?atc?gtg?ggg?tgg?cgt?cga?aaa?gca?tta?aaa?gac?acc?gag?atc 1075

Gly?Ser?Ile?Val?Gly?Trp?Arg?Arg?Lys?Ala?Leu?Lys?Asp?Thr?Glu?Ile

310 315 320 325

ggc?ggc?gtt?gcc?att?aag?gaa?ggc?gat?ggt?gtt?ctg?ctg?ctc?atg?ggt 1123

Gly?Gly?Val?Ala?Ile?Lys?Glu?Gly?Asp?Gly?Val?Leu?Leu?Leu?Met?Gly

330 335 340

tcc?gcg?aac?cgc?gat?gaa?gct?cgc?ttt?gaa?aat?ggc?gag?gaa?ttc?gat 1171

Ser?Ala?Asn?Arg?Asp?Glu?Ala?Arg?Phe?Glu?Asn?Gly?Glu?Glu?Phe?Asp

345 350 355

atc?agc?cgc?gct?aat?gcg?cgc?gag?cac?ctg?tct?ttt?ggt?ttc?ggc?atc 1219

Ile?Ser?Arg?Ala?Asn?Ala?Arg?Glu?His?Leu?Ser?Phe?Gly?Phe?Gly?Ile

360 365 370

cac?tat?tgc?cta?gga?aac?atg?ctg?gcc?aaa?ctt?caa?gcc?aag?atc?tgt 1267

His?Tyr?Cys?Leu?Gly?Asn?Met?Leu?Ala?Lys?Leu?Gln?Ala?Lys?Ile?Cys

375 380 385

ctc?gag?gaa?gtc?acc?agg?ctt?gtt?cct?tcc?ctg?cac?ttg?gtt?gcg?gac 1315

Leu?Glu?Glu?Val?Thr?Arg?Leu?Val?Pro?Ser?Leu?His?Leu?Val?Ala?Asp

390 395 400 405

aaa?gct?atc?ggg?ttc?cgg?gag?aac?ctc?tcc?ttc?cgc?gtc?ccc?act?tct 1363

Lys?Ala?Ile?Gly?Phe?Arg?Glu?Asn?Leu?Ser?Phe?Arg?Val?Pro?Thr?Ser

410 415 420

gtt?ccc?gtg?act?tgg?aac?gct?taacgcttta?ttaaataagg?aga 1407

Val?Pro?Val?Thr?Trp?Asn?Ala

425

<210>780

<211>428

<212>PRT

＜213〉Corynebacterium glutamicum

<400>780

Met?Thr?Ser?Gln?Thr?Ser?Gln?Gln?Ser?Thr?Ser?Thr?Gly?Gly?Cys?Pro

1 5 10 15

Phe?Gly?His?Thr?Ser?Glu?Ser?Thr?Ser?His?His?Gly?Tyr?Gln?Pro?Phe

20 25 30

Asp?Met?His?Asn?Pro?Phe?Pro?Ala?Tyr?Lys?Glu?Leu?Arg?Gln?Glu?Glu

35 40 45

Pro?Val?Met?Phe?Asp?Glu?Arg?Ile?Gly?Tyr?Trp?Val?Val?Thr?Lys?Tyr

50 55 60

Asp?Asp?Ile?Lys?Thr?Thr?Phe?Asp?Asp?Trp?Glu?Thr?Phe?Ser?Ser?Glu

65 70 75 80

Asn?Ala?Gln?Ala?Pro?Val?Arg?Lys?Arg?Gly?Pro?Gln?Ala?Thr?Gln?Ile

85 90 95

Met?Thr?Asp?Gly?Gly?Phe?Thr?Ala?Tyr?Ser?Gly?Leu?Ser?Ala?Arg?Ile

100 105 110

Pro?Pro?Glu?His?Thr?Arg?Ile?Arg?Ala?Ile?Ala?Gln?Lys?Ala?Phe?Thr

115 120 125

Pro?Arg?Arg?Tyr?Lys?Ala?Leu?Glu?Pro?Asp?Ile?Arg?Ala?Met?Val?Ile

130 135 140

Asp?Arg?Val?Glu?Lys?Met?Leu?Ala?Asn?Asp?Gln?His?Val?Gly?Asp?Met

145 150 155 160

Val?Ser?Asp?Leu?Ala?Tyr?Asp?Ile?Pro?Thr?Ile?Thr?Ile?Leu?Thr?Leu

165 170 175

Ile?Gly?Ala?Asp?Ile?Phe?Met?Val?Val?Thr?Tyr?Lys?Arg?Trp?Ser?Asp

180 185 190

Ser?Arg?Ala?Ala?Met?Thr?Trp?Gly?Asp?Leu?Ser?Asp?Glu?Glu?Gln?Ile

195 200 205

Pro?His?Ala?His?Asn?Leu?Val?Glu?Tyr?Trp?Gln?Glu?Cys?Gln?Arg?Met

210 215 220

Val?Ala?Asp?Ala?His?Ala?His?Gly?Gly?Asp?Asn?Leu?Thr?Ala?Asp?Leu

225 230 235 240

Val?Arg?Ala?Gln?Gln?Glu?Gly?Gln?Glu?Ile?Thr?Asp?His?Glu?Ile?Ala

245 250 255

Ser?Leu?Leu?Tyr?Ser?Leu?Leu?Phe?Ala?Gly?His?Glu?Thr?Thr?Thr?Thr

260 265 270

Leu?Ile?Ser?Asn?Cys?Phe?Arg?Val?Leu?Leu?Asp?His?Pro?Glu?Gln?Trp

275 280 285

Gln?Ala?Ile?Leu?Glu?Asn?Pro?Lys?Leu?Ile?Pro?Ala?Ala?Val?Asp?Glu

290 295 300

Val?Leu?Arg?Tyr?Ser?Gly?Ser?Ile?Val?Gly?Trp?Arg?Arg?Lys?Ala?Leu

305 310 315 320

Lys?Asp?Thr?Glu?Ile?Gly?G1y?Val?Ala?Ile?Lys?Glu?Gly?Asp?Gly?Val

325 330 335

Leu?Leu?Leu?Met?Gly?Ser?Ala?Asn?Arg?Asp?Glu?Ala?Arg?Phe?Glu?Asn

340 345 350

Gly?Glu?Glu?Phe?Asp?Ile?Ser?Arg?Ala?Asn?Ala?Arg?Glu?His?Leu?Ser

355 360 365

Phe?Gly?Phe?Gly?Ile?His?Tyr?Cys?Leu?Gly?Asn?Met?Leu?Ala?Lys?Leu

370 375 380

Gln?Ala?Lys?Ile?Cys?Leu?Glu?Glu?Val?Thr?Arg?Leu?Val?Pro?Ser?Leu

385 390 395 400

His?Leu?Val?Ala?Asp?Lys?Ala?Ile?Gly?Phe?Arg?Glu?Asn?Leu?Ser?Phe

405 410 415

Arg?Val?Pro?Thr?Ser?Val?Pro?Val?Thr?Trp?Asn?Ala

420 425

<210>781

<211>978

<212>DNA

＜213〉Corynebacterium glutamicum

<220>

<221>CDS

<222>(101)..(955)

<223>RXN00387

<400>781

ttccgcgccg?gcgccaactt?cgacggcacc?gggctgacca?ccttctgctt?tgaagcgcac?60

gatttctccg?ccgactacct?cgccaacggg?ccaggccgag?atg?ttc?cgc?tcg?aat 115

Met?Phe?Arg?Ser?Asn

1 5

att?tcc?tac?gca?gtc?ggc?gac?gac?atc?caa?aac?gac?cca?gaa?acc?tgg 163

Ile?Ser?Tyr?Ala?Val?Gly?Asp?Asp?Ile?Gln?Asn?Asp?Pro?Glu?Thr?Trp

10 15 20

gaa?gac?tac?gaa?ctt?cgc?gtc?aac?cac?cca?ctg?cgc?atc?gaa?ggc?gac 211

Glu?Asp?Tyr?Glu?Leu?Arg?Val?Asn?His?Pro?Leu?Arg?Ile?Glu?Gly?Asp

25 30 35

cgc?gtc?tac?ctt?cag?ggc?cac?ggc?ttc?gcc?cca?aca?ttc?acc?gtg?acc 259

Arg?Val?Tyr?Leu?Gln?Gly?His?Gly?Phe?Ala?Pro?Thr?Phe?Thr?Val?Thr

40 45 50

tgg?cca?aat?ggc?gag?acc?cgc?acc?cag?acc?gtg?cag?tgg?cgc?cca?gac 307

Trp?Pro?Asn?Gly?Glu?Thr?Arg?Thr?Gln?Thr?Val?Gln?Trp?Arg?Pro?Asp

55 60 65

gac?ccg?acc?ttc?ttc?ctg?tcc?tca?ggc?gtg?gtc?cgt?ttc?gat?cca?ccc 355

Asp?Pro?Thr?Phe?Phe?Leu?Ser?Ser?Gly?Val?Val?Arg?Phe?Asp?Pro?Pro

70 75 80 85

gcc?ggc?atg?tac?cca?gac?ctt?tac?gag?cgc?cgc?caa?aac?cag?ttg?gcc 403

Ala?Gly?Met?Tyr?Pro?Asp?Leu?Tyr?Glu?Arg?Arg?Gln?Asn?Gln?Leu?Ala

90 95 100

atc?cag?gga?ctt?ttc?gca?ccg?acc?gcg?gaa?tgg?gaa?ggc?gac?aac?aac 451

Ile?Gln?Gly?Leu?Phe?Ala?Pro?Thr?Ala?Glu?Trp?Glu?Gly?Asp?Asn?Asn

105 110 115

gaa?ctg?ctg?acc?tcc?tcc?tac?ccg?gcg?atg?cgt?gac?cca?gcc?gtg?gcg 499

Glu?Leu?Leu?Thr?Ser?Ser?Tyr?Pro?Ala?Met?Arg?Asp?Pro?Ala?Val?Ala

120 125 130

atc?gat?att?tac?cgc?ggc?gac?aat?ggc?ctc?gat?acc?ggc?atc?gga?cag 547

Ile?Asp?Ile?Tyr?Arg?Gly?Asp?Asn?Gly?Leu?Asp?Thr?Gly?Ile?Gly?Gln

135 140 145

tca?ttg?ttc?agc?ctg?gac?tct?agt?ctc?atg?cac?agc?ggc?gtg?ctg?caa 595

Ser?Leu?Phe?Ser?Leu?Asp?Ser?Ser?Leu?Met?His?Ser?Gly?Val?Leu?Gln

150 155 160 165

aaa?att?gag?cgc?gtc?aac?ctc?caa?atc?ggc?gac?acc?gtc?acc?ctg?gat 643

Lys?Ile?Glu?Arg?Val?Asn?Leu?Gln?Ile?Gly?Asp?Thr?Val?Thr?Leu?Asp

170 175 180

gat?ggc?acc?acc?gtc?tcc?ttc?gac?ggc?gcg?tca?gaa?ttt?gcc?aac?tac 691

Asp?Gly?Thr?Thr?Val?Ser?Phe?Asp?Gly?Ala?Ser?Glu?Phe?Ala?Asn?Tyr

185 190 195

cag?atc?agc?cgc?gac?ccc?aca?caa?aac?tgg?gtg?ctg?gtc?acc?acc?gtg 739

Gln?Ile?Ser?Arg?Asp?Pro?Thr?Gln?Asn?Trp?Val?Leu?Val?Thr?Thr?Val

200 205 210

att?tcg?ctg?gtc?tcc?ctg?gtt?gga?tcc?ctg?atg?atc?cga?cgc?cgc?cgc 787

Ile?Ser?Leu?Val?Ser?Leu?Val?Gly?Ser?Leu?Met?Ile?Arg?Arg?Arg?Arg

215 220 225

att?tgg?gtg?cgt?ttc?tat?cca?caa?gaa?aac?gga?acc?acc?cgc?gtg?gaa 835

Ile?Trp?Val?Arg?Phe?Tyr?Pro?Gln?Glu?Asn?Gly?Thr?Thr?Arg?Val?Glu

230 235 240 245

acc?ggc?gga?ctt?gcc?cgc?acc?gac?cgc?gca?ggc?tgg?ggt?ggc?gaa?tac 883

Thr?Gly?Gly?Leu?Ala?Arg?Thr?Asp?Arg?Ala?Gly?Trp?Gly?Gly?Glu?Tyr

250 255 260

gag?aaa?ttc?cac?cgc?gaa?ctg?ctg?ggt?ctg?aag?gag?gaa?gat?gaa?gac 931

Glu?Lys?Phe?His?Arg?Glu?Leu?Leu?Gly?Leu?Lys?Glu?Glu?Asp?Glu?Asp

265 270 275

gaa?gag?tac?ttc?gac?cac?gac?gac?taacaccgca?atttaaaggc?ttt 978

Glu?Glu?Tyr?Phe?Asp?His?Asp?Asp

280 285

<210>782

<211>285

<212>PRT

＜213〉Corynebacterium glutamicum

<400>?782

Met?Phe?Arg?Ser?Asn?Ile?Ser?Tyr?Ala?Val?Gly?Asp?Asp?Ile?Gln?Asn

1 5 10 15

Asp?Pro?Glu?Thr?Trp?Glu?Asp?Tyr?Glu?Leu?Arg?Val?Asn?His?Pro?Leu

20 25 30

Arg?Ile?Glu?Gly?Asp?Arg?Val?Tyr?Leu?Gln?Gly?His?Gly?Phe?Ala?Pro

35 40 45

Thr?Phe?Thr?Val?Thr?Trp?Pro?Asn?Gly?Glu?Thr?Arg?Thr?Gln?Thr?Val

50 55 60

Gln?Trp?Arg?Pro?Asp?Asp?Pro?Thr?Phe?Phe?Leu?Ser?Ser?Gly?Val?Val

65 70 75 80

Arg?Phe?Asp?Pro?Pro?Ala?Gly?Met?Tyr?Pro?Asp?Leu?Tyr?Glu?Arg?Arg

85 90 95

Gln?Asn?Gln?Leu?Ala?Ile?Gln?Gly?Leu?Phe?Ala?Pro?Thr?Ala?Glu?Trp

100 105 110

Glu?Gly?Asp?Asn?Asn?Glu?Leu?Leu?Thr?Ser?Ser?Tyr?Pro?Ala?Met?Arg

115 120 125

Asp?Pro?Ala?Val?Ala?Ile?Asp?Ile?Tyr?Arg?Gly?Asp?Asn?Gly?Leu?Asp

130 135 140

Thr?Gly?Ile?Gly?Gln?Ser?Leu?Phe?Ser?Leu?Asp?Ser?Ser?Leu?Met?His

145 150 155 160

Ser?Gly?Val?Leu?Gln?Lys?Ile?Glu?Arg?Val?Asn?Leu?Gln?Ile?Gly?Asp

165 170 175

Thr?Val?Thr?Leu?Asp?Asp?Gly?Thr?Thr?Val?Ser?Phe?Asp?Gly?Ala?Ser

180 185 190

Glu?Phe?Ala?Asn?Tyr?Gln?Ile?Ser?Arg?Asp?Pro?Thr?Gln?Asn?Trp?Val

195 200 205

Leu?Val?Thr?Thr?Val?Ile?Ser?Leu?Val?Ser?Leu?Val?Gly?Ser?Leu?Met

210 215 220

Ile?Arg?Arg?Arg?Arg?Ile?Trp?Val?Arg?Phe?Tyr?Pro?Gln?Glu?Asn?Gly

225 230 235 240

Thr?Thr?Arg?Val?Glu?Thr?Gly?Gly?Leu?Ala?Arg?Thr?Asp?Arg?Ala?Gly

245 250 255

Trp?Gly?Gly?Glu?Tyr?Glu?Lys?Phe?His?Arg?Glu?Leu?Leu?Gly?Leu?Lys

260 265 270

Glu?Glu?Asp?Glu?Asp?Glu?Glu?Tyr?Phe?Asp?His?Asp?Asp

275 280 285

<210>783

<211>18

<212>DNA

＜213〉artificial sequence

<220>

＜223〉artificial sequence description: primer

<400>783

ggaaacagta?tgaccatg 18

<210>784

<211>17

<212>DNA

＜213〉artificial sequence

<220>

＜223〉artificial sequence description: primer

<400>784

gtaaaacgac?ggccagt

Claims (68)

1. an isolating Corynebacterium glutamicum nucleic acid molecule or its complementary sequence, described nucleic acid molecule comprises each the odd number nucleotide sequence that is selected from SEQ ID NO:3 to 781, and prerequisite is that described nucleic acid molecule is not made up of any F marker gene that table 1 provides.

2. an isolated nucleic acid molecule or its complementary sequence, described nucleic acid molecule encoding one peptide species, described polypeptide comprises each the even number aminoacid sequence that is selected from SEQ ID NO:4 to 782, and prerequisite is that described nucleic acid molecule is not made up of any F marker gene that table 1 provides.

3. an isolated nucleic acid molecule or its complementary sequence, the naturally occurring allelic variation body of described nucleic acid molecule encoding polypeptide, described polypeptide comprises each the even number aminoacid sequence that is selected from SEQ ID NO:4 to 782, and prerequisite is that described nucleic acid molecule is not made up of any F marker gene that table 1 provides.

4. an isolated nucleic acid molecule or its complementary sequence, described nucleic acid molecule comprises the nucleotide sequence of showing at least 50% identity with the complete nucleotides sequence of any odd number of SEQID NO:3 to 781, and prerequisite is that described nucleic acid molecule is not made up of any F marker gene that table 1 provides.

5. an isolated nucleic acid molecule or its complementary sequence, described nucleic acid molecule comprises the fragment of at least 15 continuous nucleotides of any odd number nucleotide sequence of SEQ IDNO:3 to 781, and prerequisite is that described nucleic acid molecule is not made up of any F marker gene that table 1 provides.

6. isolated nucleic acid molecule, it comprise claim 1-5 each nucleic acid molecule and the nucleotide sequence of coding heterologous polypeptide.

7. carrier, it comprises each nucleic acid molecule of claim 1-6.

8. the carrier of claim 7, it is an expression vector.

9. host cell, it is the host cell with the expression vector transfection of claim 8.

10. the host cell of claim 9, wherein said cell is a microorganism.

11. the host cell of claim 10, wherein said cell belongs to Corynebacterium or brevibacterium sp.

12. the host cell of claim 9, the expression of wherein said nucleic acid molecule produces fine chemicals to described cell and produces adjusting.

13. the host cell of claim 12, wherein said fine chemicals is selected from: organic acid, formation protein and the proteinic amino acid of non-formation, purine and pyrimidine bases, nucleosides, Nucleotide, lipid, saturated and non-saturated fatty acid, dibasic alcohol, carbohydrate, aromatics, VITAMIN, cofactor, polyketide and enzyme.

14. a method that produces polypeptide, this method are included in the host cell of cultivating claim 9 in the suitable culture medium, produce described polypeptide thus.

15. an isolated polypeptide, described polypeptide comprise each the even number aminoacid sequence that is selected from SEQ ID NO:4 to 782, prerequisite is that described aminoacid sequence is not to be encoded by any F marker gene that table 1 provides.

16. isolated polypeptide, described polypeptide comprises the naturally occurring allelic variation body of the polypeptide that contains each the even number aminoacid sequence that is selected from SEQ ID NO:4 to 782, and prerequisite is that described aminoacid sequence is not any F marker gene coding that is provided by table 1.

17. isolated polypeptide, described polypeptide is by a kind of nucleic acid molecule encoding, described nucleic acid molecule comprises the nucleotide sequence that at least 50% identity is arranged with the complete nucleotide sequence of any odd number of SEQ ID NO:3 to 781, and prerequisite is that described nucleic acid molecule is not made up of any F sign nucleic acid molecule that table 1 provides.

18. an isolated polypeptide, described polypeptide comprise the aminoacid sequence that at least 50% identity is arranged with any even number complete amino acid sequence of SEQ ID NO:4 to 782, prerequisite is that described aminoacid sequence is not any F marker gene coding that is provided by table 1.

19. isolated polypeptide, described polypeptide comprises the fragment of the polypeptide that contains any even number aminoacid sequence that is selected from SEQ ID NO:4 to 782, prerequisite is that described aminoacid sequence is not any F marker gene coding that is provided by table 1, and described polypeptide fragment keeps the biological activity of the polypeptide that contains described aminoacid sequence.

20. an isolated polypeptide, described polypeptide are by a kind of nucleic acid molecule encoding, described nucleic acid molecule comprises any odd number nucleotide sequence of SEQ ID NO:3 to 781, and prerequisite is that described nucleic acid molecule is not made up of any F sign nucleic acid molecule that table 1 provides.

21. each isolated polypeptide of claim 15-20, it further comprises the allogeneic amino acid sequence.

22. a method that produces fine chemicals, this method comprises the cell of cultivating claim 9, produces described fine chemicals thus.

23. the method for claim 22, wherein said method also comprises the step that reclaims described fine chemicals from culture.

24. the method for claim 22, wherein said cell belongs to Corynebacterium or brevibacterium sp.

25. the method for claim 25, wherein said cell is selected from: Corynebacterium glutamicum (Corynebacterium glutamicum), man of great strength's rod bacillus (Corynebacterium herculis), lily hedysarum scoparium bacillus (Corynebacterium lilium), Corynebacterium acctoacidophlum (Corynebacterium acetoacidophilum), vinegar paddy rod bacillus (Corynebacteriumacetoglutamicum), have a liking for acetyl rod bacillus (Corynebacterium acetophilum), produce ammonia rod bacillus (Corynebacterium ammoniagenes), Corynebacterium fujiokense, Corynebacterium nitrilophilus, Brevibacterium ammoniagenes (Brevibacteriumammoniagenes), Brevibacterium butanicum, brevibacterium glutamicus (Brevibacterium divaricatum), brevibacterium flavum (Brevibacterium flavum), Xi Shi tyrothricin (Brevibacterium healii), ketoisocaproic tyrothricin (Brevibacteriumketoglutamicum), Brevibacterium ketosoreductum, brevibacterium (Brevibacterium lactofermentum), extension brevibacterium (Brevibacterium linens), the bacterial strain that Brevibacterium paraffinolyticum and table 3 provide.

26. the method for claim 22 is wherein made by the described nucleic acid molecule of described vector expression the generation of described fine chemicals is regulated.

27. the method for claim 22, wherein said fine chemicals is selected from: organic acid, formation protein and the proteinic amino acid of non-formation, purine and pyrimidine bases, nucleosides, Nucleotide, lipid, saturated and non-saturated fatty acid, dibasic alcohol, carbohydrate, aromatics, VITAMIN, cofactor, polyketide and enzyme.

28. the method for claim 22, wherein said fine chemicals are amino acid.

29. the method for claim 28, wherein said amino acid is selected from: Methionin, L-glutamic acid, glutamine, L-Ala, aspartic acid, glycine, Serine, Threonine, methionine(Met), halfcystine, Xie Ansuan, leucine, Isoleucine, arginine, proline(Pro), Histidine, tyrosine, phenylalanine and tryptophane.

30. a method that produces fine chemicals, this method comprise cultivate its genomic dna because contain claim 1-6 each nucleic acid molecule and the cell that changes.

31. whether have corynebacterium diphtheriae or its active method in the diagnosis subject, this method comprises whether detection exists at least a in the peptide molecule of the nucleic acid molecule of claim 1-5 or claim 15-20, diagnoses whether have corynebacterium diphtheriae or its active situation in the described subject thus.

32. a host cell, it comprises each the odd number nucleic acid molecule that is selected from SEQ ID NO:3-781, and prerequisite is that described nucleic acid molecule is not made up of any F flag sequence that table 1 provides, and wherein said nucleic acid molecule is destroyed.

33. a host cell, it comprises each the odd number nucleic acid molecule that is selected from SEQ ID NO:3-781, and wherein said nucleic acid molecule comprises one or more nucleic acid modifications with respect to any odd number sequence of SEQ ID NO:3-781.

34. host cell, it comprises each the odd number nucleic acid molecule that is selected from SEQ ID NO:3-781, prerequisite is that described nucleic acid molecule is not any F flag sequence that table 1 provides, and wherein with respect to the wild-type regulatory region of described molecule, has modified the regulatory region of described nucleic acid molecule.

35. an isolating Corynebacterium glutamicum nucleic acid molecule or its complementary sequence, described nucleic acid molecule comprises the nucleotide sequence of SEQ ID NO:179.

36. an isolated nucleic acid molecule or its complementary sequence, described nucleic acid molecule encoding comprise the polypeptide of the aminoacid sequence of SEQ ID NO:180.

37. an isolated nucleic acid molecule or its complementary sequence, the naturally occurring allelic variation body of described nucleic acid molecule encoding polypeptide, described polypeptide comprises the aminoacid sequence of SEQ ID NO:180.

38. an isolated nucleic acid molecule or its complementary sequence, described nucleic acid molecule comprise the nucleotide sequence of showing at least 50% identity with the complete nucleotides sequence of SEQ ID NO:179.

39. an isolated nucleic acid molecule or its complementary sequence, described nucleic acid molecule comprise the fragment of at least 15 continuous nucleotides of the nucleotide sequence of SEQ ID NO:179.

40. an isolated nucleic acid molecule, it comprise claim 35-39 each nucleic acid molecule and the coding heterologous polypeptide nucleotide sequence.

41. a carrier, it comprises each nucleic acid molecule of claim 35-40.

42. the carrier of claim 41, it is an expression vector.

43. a host cell, it is the host cell with the expression vector transfection of claim 42.

44. the host cell of claim 43, wherein said cell is a microorganism.

45. the host cell of claim 44, wherein said cell belongs to Corynebacterium or brevibacterium sp.

46. the host cell of claim 43, the expression of wherein said nucleic acid molecule produces fine chemicals to described cell and produces adjusting.

47. the host cell of claim 44, wherein said fine chemicals is selected from: organic acid, formation protein and the proteinic amino acid of non-formation, purine and pyrimidine bases, nucleosides, Nucleotide, lipid, saturated and non-saturated fatty acid, dibasic alcohol, carbohydrate, aromatics, VITAMIN, cofactor, polyketide and enzyme.

48. a method that produces polypeptide, this method are included in the host cell of cultivating claim 43 in the suitable culture medium, produce described polypeptide thus.

49. an isolated polypeptide, it comprises the aminoacid sequence of SEQ ID NO:180.

50. an isolated polypeptide, it comprises the naturally occurring allelic variation body of the polypeptide of the aminoacid sequence that contains SEQ ID NO:180.

51. an isolated polypeptide, it is by nucleic acid molecule encoding, and described nucleic acid molecule comprises the nucleotide sequence that at least 50% identity is arranged with the complete nucleotide sequence of SEQ ID NO:179.

52. an isolated polypeptide, it comprises the aminoacid sequence that at least 50% identity is arranged with the complete amino acid sequence of SEQ ID NO:180.

53. an isolated polypeptide, it comprises the fragment of the polypeptide of the aminoacid sequence that contains SEQ ID NO:180, and wherein said polypeptide fragment keeps the biological activity of the polypeptide of the aminoacid sequence that contains SEQ ID NO:180.

54. an isolated polypeptide, it is by the nucleic acid molecule encoding of the nucleotide sequence that comprises SEQ ID NO:179.

55. each isolated polypeptide of claim 49-54, it further comprises the allogeneic amino acid sequence.

56. a method that produces fine chemicals, this method comprises the cell of cultivating claim 43, produces described fine chemicals thus.

57. the method for claim 56, wherein said method also comprises the step that reclaims described fine chemicals from culture.

58. the method for claim 56, wherein said cell belongs to Corynebacterium or brevibacterium sp.

59. the method for claim 56, wherein said cell is selected from: Corynebacterium glutamicum (Corynebacterium glutamicum), man of great strength's rod bacillus (Corynebacteriumherculis), lily hedysarum scoparium bacillus (Corynebacterium lilium), Corynebacterium acctoacidophlum (Corynebacterium acetoacidophilum), vinegar paddy rod bacillus (Corynebacteriumacetoglutamicum), have a liking for acetyl rod bacillus (Corynebacterium acetophilum), produce ammonia rod bacillus (Corynebacterium ammoniagenes), Corynebacterium fujiokense, Corynebacterium nitrilophilus, Brevibacterium ammoniagenes (Brevibacteriumammoniagenes), Brevibacterium butanicum, brevibacterium glutamicus (Brevibacterium divaricatum), brevibacterium flavum (Brevibacterium flavum), Xi Shi tyrothricin (Brevibacterium healii), ketoisocaproic tyrothricin (Brevibacteriumketoglutamicum), Brevibacterium ketosoreductum, brevibacterium (Brevibacterium lactofermentum), extension brevibacterium (Brevibacterium linens), the bacterial strain that Brevibacterium paraffinolyticum and table 3 provide.

60. the method for claim 56 is wherein made by the described nucleic acid molecule of described vector expression the generation of described fine chemicals is regulated.

61. the method for claim 56, wherein said fine chemicals is selected from: organic acid, formation protein and the proteinic amino acid of non-formation, purine and pyrimidine bases, nucleosides, Nucleotide, lipid, saturated and non-saturated fatty acid, dibasic alcohol, carbohydrate, aromatics, VITAMIN, cofactor, polyketide and enzyme.

62. the method for claim 56, wherein said fine chemicals are amino acid.

63. the method for claim 62, wherein said amino acid is selected from: Methionin, L-glutamic acid, glutamine, L-Ala, aspartic acid, glycine, Serine, Threonine, methionine(Met), halfcystine, Xie Ansuan, leucine, Isoleucine, arginine, proline(Pro), Histidine, tyrosine, phenylalanine and tryptophane.

64. a method that produces fine chemicals, this method comprise cultivate its genomic dna because contain claim 35-40 each nucleic acid molecule and the cell that changes.

65. whether a diagnosis exists corynebacterium diphtheriae or its active method, this method comprises whether detection exists at least a in the peptide molecule of the nucleic acid molecule of claim 35-39 or claim 49-54, and whether diagnosis exists corynebacterium diphtheriae or its active situation thus.

66. a host cell, it comprises the nucleic acid molecule of SEQ ID NO:179, and wherein said nucleic acid molecule is destroyed.

67. a host cell, it comprises the nucleic acid molecule of SEQ ID NO:179, and wherein said nucleic acid molecule comprises one or more nucleic acid modifications with respect to the sequence of SEQ ID NO:179.

68. a host cell, it comprises the nucleic acid molecule of SEQ ID NO:179, wherein with respect to the wild-type regulatory region of described nucleic acid molecule, has modified the regulatory region of described nucleic acid molecule.