MXPA01012845A - Corynebacterium glutamicum. - Google Patents

Abstract

Isolated nucleic acid molecules, designated MCT nucleic acid molecules, which encode novel MCT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MCT proteins, mutated MCT proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MCT genes in this organism.

Description

GENES OF CORYNEBACTERIUM GLUTAMICUM THAT CODIFY PROTEINS INVOLVED IN THE SYNTHESIS OF MEMBRANE AND THE TRANSPORT OF MEMBRANE Related Requests This application claims priority of the previously filed US Provisional Patent Application Serial No. 60/141031, filed on June 25, 1999. This application also claims priority of German Patent Application No. 19931454.3, filed on July 8, 1999, German Patent Application No. 19931478.0, filed July 8, 1999, German Patent Application No. 19931563.9, filed July 8, 1999, German Patent Application No. 19932122.1, filed on July 9, 1999, German Pater.re Application No. 19932124.8, filed on July 9, 1999, German Patent Application No. 19932125.6, filed on July 9, 1999, German Patent Application No. No. 19932128.0, filed July 9, 1999, German Patent Application No. 19932180.9, filed July 9, 1999, German Patent Application No. 19932182.5, filed on the 9th. of July 1999, German Patent Application No. 19932190.6, filed on July 9, 1999, German Patent Application No. 19932191.4, filed on July 9, 1999, German Patent Application No. 19932209.0, filed on the day July 9, 1999, German Patent Application No. 19932212.0, filed July 5, 1999, German Patent Application No. 1993222".9, filed on July 9, 1999, German Patent Application No. 19932228.7 , filed on July 9, 1999, German Patent Application No. 19932229.5, preserved on July 9, 1999, German Patent Application No. 19932230.9, filed on July 9, 1999, German Patent Application No 19932927.3, filed July 14, 1999, German Patent Application No. 19923005.0, filed July 14, 1999, German Patent Application No. 19933006.9, filed July 14, 1999, German Patent Application No. 19940764.9, preser.tad on August 27, 1999, Patent Application Ale-ana Nc. 19940765.7, filed August 27, 1999, German Patent Application No. 19940766.5, filed August 27, 1999, German Patent Application No. 19P4083C.0, filed on August 27, 1999, Patent Application German No. 19940831.9, filed on August 27: 1999, German Patent Application No. 19940832.7, filed on August 27, 1999, Patent Application Ale-ana Ne. 19940833.5, filed August 27, 1999, German Patent Application No. 19941378.9, filed on August 31, 1999, German Patent Application No. 19541379.7, filed on August 31, 1999, German Patent Application No. 19941395.9, filed on August 31: 1999, German Patent Application No. 19942077.7, filed on September 3, 1999, German Patent Application No. 19942079.3, filed on September 3, 1999, and Application of German Patent No. 19942088.2, filed on September 3, 1999. All the contents of all of the applications mentioned above are hereby expressly incorporated by reference. BACKGROUND OF THE INVENTION Certain products and byproducts of metabolic processes that occur naturally in cells are useful in a wide range of industries, including the food, cosmetic and pharmaceutical industries. These molecules, collectively known as "fine chemicals" include organic acids, both protogenic and non-proteinogenic amino acids, nucleotides and nuclecides, lipids and fatty acids, diols, carbohydrates, aromatics, vitamins and cofactors and enzymes. Their production is most conveniently carried out through large scale cultivation of bacteria developed to produce and secrete large quantities of a particularly desired mule. A particularly useful organism for this purpose is Corynebacterium glutamicum, a non-pathogenic, gram-positive bacterium. Through selection by staining, numerous strains have been developed which produce a gar.a of desirable compounds. However, the selection of improved strains for the production of a particular molecule is a difficult process that requires a lot of time. COMPENDIUM OF THE INVENTION The invention offers novel bacterial nucleic acid molecules that have several uses. These uses include the identification of microorganisms that can be used to produce fine chemicals, the modulation of the production of fine chemicals in C. glutamicum or related bacteria, the determination of the type or identification of Z. glutamicum or related bacteria, with reference points for the mapping of the genome of C. glutamicum, and eat - markers for transformation. These novel nucleic acid molecules encode proteins, which are known herein cer.c membrane construction proteins and membrane transport (MCT). C. glutamicum is an aerobic, gram-positive bacterium commonly used in the industry for the large-scale production of several fine chemicals and also for the degradation of hydrocarbons (as, for example, in the case of oil spills) and for the oxidation of terpenoids. The MCT nucleic acid molecules of the invention can therefore be used to identify microorganisms that can be used to produce fine chemicals such as, for example, by fermentation processes. The modulation of the expression of the MCT nucleic acids of the invention, or modification of the sequence of the MCT nucleic acid molecules of the invention, can be used to modulate the production of one or several fine chemicals from a microorganism ( for example, to improve the yield or production of one or several fine chemicals from a species of Corynebacterium or Brevibacterium). The MCT nucleic acids of the invention can also be used to identify an organism as being Corynebacterium glutamicum or a closely related organism thereof, or to identify the presence of C. glutamicum or a related organism thereof in a mixed population. of microorganisr.es. The invention offers the nucleic acid sequences of numerous C. glutamicum genes; By probing the genomic DNA extracted from a culture of a single or mixed population of microorganisms under strict conditions with a probe that covers a region of a gene for C. glutamicum that is unique to this organism, it can be determined if this organism is found I presented. Although Corynebacterium glutamicum itself is not pathogenic, it is related to pathogenic species for humans such as Corynebacterium diphtheriae (the causative agent of diphtheria); The detection of these organisms is of significant clinical relevance. The MCT nucleic acid molecules of the present invention can also serve as reference points to map the genome of C. glutar.icum to the genomes of related organisms. Similarly, these molecules or variants or portions thereof can serve as markers for genetically engineered Corynebacterium or Brevibacterium species. The MCT proteins encoded by the novel nucleic acid molecules of the present invention can, for example, play a role involved in the metabolism (for example, the biosynthesis or degradation) of compounds necessary for membrane biosynthesis, or to aid the transmembrane transport of one or several compounds either towards the cell or outside the cell. Given the availability of cloning vectors for use in Corynebacterium glutamicum, such vectors disclosed in Sinskey et al., US Patent No. 4,649,119, and techniques for genetic manipulation of C. glutamicum and the related Brevibacterium species (eg, lactofermenum) (Yoshihama et al, J. Bacteriol. 162: 591-597 (1985); Katsu ata et al., J. Bacteriol. 159: 306-311 (1984); and Santamaría et al., J. Gen. Microbiol. 130: 2237-2246 _1984)), the nucleic acid molecules of the present invention can be used in the genetic manipulation of this organism to make said organism a better or more efficient producer of one or more fine chemicals. This production or improved production efficiency of a fine chemical may be due to a direct effect of the manipulation of a gene of the invention or may be due to an indirect effect of such manipulation. There are numerous mechanisms through which the alteration of a MCT protein of the present invention can directly affect the yield, production, and / or production efficiency of a fine chemical from a strain of C. glutamicum incorporating said protein altered These MCT proteins involved in the export of fine chemical molecules from the cell can be increased in number or activity in such a way that larger amounts of these components are secreted into the extracellular medium, from which they are more easily recovered. . In a similar way, these MCT proteins involved in the importation of nutrients necessary for the biosynthesis of one or more fine chemicals (for example, phosphate, sulphate, nitrogen compounds, etc.) can be increased in number or activity such that these precursors, co-factors, or intermediate compounds have an increased concentration within the cell. In addition, fatty acids and lipids are more desirable fine chemicals; by optimizing the activity or increasing the number of one or more MCT proteins of the invention participating in the biosynthesis of these compounds, or by affecting the activity of one or more MCT proteins involved in the degradation of These compounds, it may be possible to increase the yield, production and / or production efficiency of fatty acid and lipid molecules from C. glutamicum. The mutagenesis of one or more MCT genes of the invention can also result in MCT proteins having altered activities that have an indirect impact on the production of one or more desired fine chemicals from C. glutamicum. For example, MCT proteins of the present invention involved in the export of residual products can be increased in number or activity in such a way that the normal metabolic residues of the cell (possibly increased in quantity due to the overproduction of the desired fine chemical ) are efficiently exported before they can damage nucleotides and proteins inside the cell (which would decrease the viability of the cell) or before they can interfere with the biosynthetic pathways of fine chemicals (which would diminish the yield, production, or efficiency of production of the desired fine chemical). Oils, the relatively large intracellular amounts of the desired fine chemical can, in themselves be toxic to the cell, so that by increasing the activity or number of transporters that can export this cell corred, the viability of the cell can be increased. the cell in culture, which in turn causes a greater number of cells in the culture that produce the desired fine chemical. The MCT proteins of the invention can also be manipulated in such a way that relative amounts of molecules other than lipid and fatty acid are produced. They can have a profound effect on the lipid composition of the cell membrane. Since each type of lipid has different physical properties, an alteration of the composition- of the lipids of a membrane can significantly alter the fluidity of the membrane. Changes in membrane fluidity may have an effect on the transport of molecules through the membrane, as well as on the integrity of the cell, but aspects having a profound effect on the production of fine chemicals from C. glutamicum in fermentative culture. on a large scale. The invention offers novel nucleic acid molecules that encode proteins, which are known here as MCT proteins, which can, for example, participate in the metabolism of compounds necessary for the construction of cellular membrane in C. glutamicum, or in transport of molecules through these membranes. Nucleic acid molecules encoding a MCT protein are referred to herein as MCT nucleic acid molecules. In a preferred embodiment, the MCT protein participates in the metabolism of compounds necessary for the construction of cell membranes in C. glutamicum or in the transport of molecules through these membranes. Examples of such proteins include the proteins encoded by the genes presented in Table 1. Accordingly, one aspect of the invention relates to isolated nucleic acid molecules (e.g. cDNA, DNA or RNAs) that comprise a nucleotide sequence that encodes an MCT protein or biologically active portions thereof, as well as nucleic acid fragments suitable as primers or hybridization probes for the detection or amplification of nucleic acid encoding MCT (eg, DNA or mRNA). In particularly preferred embodiments, the isolated nucleic acid molecule comprises one of the nucleotide sequences presented as SEQ ID NOs of an odd number in the Sequence List (eg, SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 7 ...), either the coding region or a complement thereof of one of these nucleotide sequences. In other particularly preferred embodiments, the isolated nucleic acid molecule of the present invention comprises a nucleotide sequence that hybridizes or is at least about 50%, preferably at least about 60%, more preferably at least about 70%, 80% or 90%, and even greater preferably at least about 95%, 96%, 97%, 98%, 99% or more homologous with a nucleotide sequence presented as SEQ ID NO of odd number in the List of Sequences (for example SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 7 ..), or a portion thereof. In other preferred embodiments, the isolated nucleic acid molecule encodes one of the amino acid sequences presented as SEQ ID NO of even number in the Sequence Listing (eg, SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO : 6, SEQ II NO: 8 ...). The preferred MCT proteins of the present invention also preferably possess at least one of the MCT activities described herein. In another embodiment, the isolated nucleic acid molecule encodes a protein or portion of the earth, wherein the protein or portion thereof includes an amino acid sequence that is sufficiently homologous with an amino acid sequence of the invention (for example, a sequence having a SEQ ID NO: of even number in the Sequence List), for example, sufficiently homologous with an amino acid sequence of the invention in such a way that the protein or portion thereof maintains an MCT activity. Preferably, the protein or portion of the misita encoded by the nucleic acid molecule retains the ability to participate in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum or in the transport of molecules through these membranes. In one embodiment, the protein encoded by the nucleic acid molecule has a homology of at least about 50%, preferably of at least about 60%, and more preferably at least about 70%, 80%, or 90% and most especially at least about 95%, 96%, 97%, 9c% or 99% or more with an amino acid sequence of the invention (for example, an entire amino acid sequence selected from those having an SEQ ID: of even number in the Sequence List). In another preferred embodiment, the protein is a full-length C. glutamicum protein substantially homologous with a whole amino acid sequence of the invention (encoded by the open reading frame shown in the samples SEQ ID NC: corresponding odd-numbered in the List of Sequences, for example, SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 7 ...). In another preferred embodiment, the isolated nucleic acid molecule is derived from C. glutamicum and encodes a protein (such as, for example, an MCT fusion protein) that includes a biologically active domain having a homology level of at least about 50% or more with a biologically active domain of the amino acid sequences of the invention (such as for example, a sequence of one of the SEQ ID Nos: even number in the Sequence List) and can participate in the metabolism of compounds necessary for the construction of cell membranes in C. glutamicum, or in the transport of molecules to through these membranes, or possesses one or more of the activities presented in Table 1, and which also includes heterologous nucleic acid sequences encoding a polypeptide or regulatory regions. In another embodiment, the isolated nucleic acid molecule is at least 15 nucleotides in length and hybridizes under stringent conditions to a nucleic acid molecule comprising a nucleic acid sequence of the invention, for example, a sequence of SEQ ID NOS. NO: with an odd number in the Sequence List). Preferably, the isolated nucleic acid molecule corresponds to a naturally occurring nucleic acid molecule. More preferably, the isolated nucleic acid encodes a naturally occurring MCT protein of C. glutamicum, or a biologically active portion thereof. Another aspect of the invention relates to vectors e.g., expression, recombination vectors containing the nucleic acid molecules of the invention, and host cells in which such vectors have been introduced. In one embodiment, said host cell is used to produce a MCT protein by culturing the host cell in a suitable medium. The MCT protein can be isolated from the host cell or medium. In another aspect, the invention relates to a genetically modified microorganism wherein an MCT gene has been introduced or altered. In the embodiment, the genome of the microorganism has been altered by introducing a nucleic acid molecule of the invention that encodes a wild-type or mutated MCT sequence as a transgene. In another embodiment, an endogenous MCT gene within the genome of the microorganism has been altered, for example, functionally affected, by homologous recombination with an altered MCT gene. In another embodiment, an endogenous or introduced MCT gene er. a microorganism has been altered by one or several point mutations, removals or inversions, but it continues to encode a functional MCT protein. In another embodiment, one or more of the regulatory regions (eg, a promoter, repressor or inducer) of MCT gene in a microorganism has been altered (e.g., by removal, truncation, inversion or dot mutation) in such a manner. that the expression of the MCT gene is modulated. In a preferred embodiment, the microorganism belongs to the genus Corynebacterium or Brevibacterium, with particular preference being given to Corynebacterium glutamicum. In a preferred embodiment, the microorganism is also used for the production of a desired compound, such as for example amino acid, lysine being particularly preferred. In another aspect, the invention provides a method for identifying the presence or activity of Corynebacterium diphtheria in a subject. This method includes the detection of one or more of the nucleic acid or amino acid sequences of the invention (eg, the sequences presented in the Sequence List as S? Q ID NOs 1 to 676)) in a subject, detecting from this forms the presence or activity of Corynebacterium diphtheria in the subject. Another aspect of the present invention relates to an isolated MCT protein or to a portion, for example, a biologically active portion thereof. In a preferred embodiment, the MCT protein isolated or portion thereof may participate in the metabolism of compounds necessary for the construction of cell membranes in C. glutamicum, or in the transport of molecules through these membranes. In another preferred embodiment, the isolated MCT protein or portion thereof is sufficiently homologous with an amino acid sequence of the invention (eg, a sequence of a SEQ ID NO: even number in the Sequence List) in such a manner that the protein portion of it maintains the capacity to participate, in the metabolism of compounds necessary for the construction of cell membranes in C. glutamicum, or in the transport of molecules through these membranes.

The invention also offers an isolated preparation of a MCT protein. In preferred embodiments, the MCT protein comprises an amino acid sequence of the invention (eg, a sequence of a SEQ ID No: even number from the Sequence List). In another preferred embodiment, the invention relates to a full-length protein isolated substantially homologous to an entire amino acid sequence of the present invention (eg, a sequence of SEQ ID NO: even number from the Sequence List) (encoded by the "open reading frame set forth in SEQ ID NO: corresponding odd number of the Sequence List." In another embodiment, the protein has a homology of at least about 50%, preferably at least about 60%. %, more preferably at least about 70%, 80%, or 90%, and most especially at least about 95%, 96%, 97%, 98%, or 99% or more with an amino acid sequence of the invention (for example, a sequence of a SEQ ID NO: even number of the Sequence List) In other embodiments, the isolated MCT protein comprises an amino acid sequence having a homology of at least about 50% or? r.á, s with one of the amino acid sequences of the invention (eg, a sequence of a SEQ ID NO: even number from the Sequence List) and can participate in the metabolism of compounds necessary for the construction of cell membranes in C. glutamicum or in the transport of molecules through these membranes, or has one or more of the activities presented in Table 1. Alternatively, the isolated MCT protein may comprise a sequence of amino acid that is encoded by the sequence of nucleotides that hybridize, for example, hybridizes under stringent conditions, or has a homology level of at least about 50%, preferably at least about 60%, with higher preference of at least about 7%, 80%, or 90% and most especially at least about "95%, 96%, 97%, 98% or 99% or more with a nucleotide sequence of one of the SEQ's ID NOs with even numbers presented in the Sequence List. It is also preferred that the preferred forms of MCT proteins have one or more of the MCT bioactivities described herein. The MCT polypeptide, or a biologically active portion thereof, can be operably linked to a non-MCT polypeptide to form a fusion protein. In preferred embodiments, this fusion protein has an activity that differs from the activity of the MCT protein alone. In other preferred embodiments, this fusion protein participates in the metabolism of compounds necessary for the construction of cell membranes in C. glutamicum, or in the transport of molecules through these membranes. In particularly preferred embodiments, the integration of this fusion protein into a host cell modulates the production of a desired compound from the cell. In another aspect, the invention offers methods for screening molecules that modulate the activity of a MCT protein, either by interaction with the protein itself or a substrate or binding partner of the MCT protein, or by modulation of the protein. transcription or -translation of a MCT nucleic acid molecule of the invention. Another aspect of the invention relates to a method for the production of a fine chemical. This method includes culturing a cell containing a vector that directs the expression of a MCT nucleic acid molecule of the invention, such that it produces a fine chemical. In a preferred embodiment, this method includes the step of obtaining a cell containing said vector, wherein a cell is affected with a vector that directs the expression of an MCT nucleic acid. In another preferred embodiment, this method further includes the step of recovering the fine chemical from the culture. in a particularly preferred embodiment, the cell is of the genus Corynebacterium or Brevibacterium or is selected from the strains presented in Table 3.

Another aspect of the invention relates to methods for modulating the production of a molecule from a microorganism. Such methods include contacting the cell with an agent that modulates the MCT protein activity or MCT nucleic acid expression in such a way that an activity associated with a cell is altered in relation to said activity in the absence of the agent. . In a preferred embodiment, the cell is modulated for one or several metabolic pathways of C. glutamicum for cellular membrane components or is modulated for the transport of compounds through such membranes, such that the yields or production rate of a fine chemical desired by this microorganism to rise. The agent that modulates the MCT protein activity may be an agent that stimulates MCT protein activity or MCT nucleic acid expression. Examples of agents that stimulate MCT protein activity or MCT nucleic acid expression include small molecules, active MCT proteins, and nucleic acids that encode MCT proteins that have been introduced into the cell. Examples of agents that inhibit MCT activity or MCT expression include small molecules as well as antisense MCT nucleic acid molecules. Another aspect of the invention relates to methods for modulating yields of a desired compound from a cell, including the introduction of a mutant or wild-type MCT gene into a cell, either maintained in a separate or integrated plasmid. in the genome of the host cell. If it is integrated into the genome, said integration can be random or it can be carried out by homologous recombination in such a way that the native gene is replaced by the introduced copy, causing the production of the desired compound from the cell to be modulated. In a preferred embodiment, said yields are increased. In another preferred embodiment, said chemical agent is a fine chemical. In a particularly preferred embodiment, said fine chemical is an amino acid. In especially preferred embodiments, said amino acid is L-lysine. DETAILED DESCRIPTION OF THE INVENTION The present invention offers MCT protein and nucleic acid molecules involved in the metabolism of cellular membrane components in C. glutamicum or in the transport of compounds through such membranes. The molecules of the invention can be used in the modulation of the production of fine chemicals from microorganisms such as C. glutamicum, either directly (for example, where the overexpression or optimization of a fatty acid biosynthesis protein has a direct impact on the yield, production, and / or production efficiency of the fatty acid from modified C. glutamicum), or may have an indirect impact that results in an increase in yield, production and / or production efficiency of the desired compound (for example, wherein the modulation of the metabolism of cell membrane components results in alterations in yield, production and / or production efficiency or the composition of the cell membrane, which in turn can have an impact on the production of one or more chemical purposes). Aspects of the invention are explained in more detail below. I. FINE CHEMICALS The term "fine chemical" is an expression well known in the art that includes molecules produced by an organism that has applications in various industries such as, for example, without limitation, the pharmaceutical, agricultural and cosmetic industries. Such compounds include organic acids such as tartaric acid, itaconic acid and diaminopimelic acid, both proteinogenic and non-proteinogenic amino acids, purine and pyrimidine bases, nucleosides and nucleotides (according to the writing, for example in Kuninaka, A. (1996) Nucleotides and related compounds, p. 561-612, in Biotechnology vol. 6, Rehm et al., Eds. VCH: Weinheim, and references contained therein, lipids, both saturated and unsaturated fatty acids for example, arachidonic acid), diols (for example, propandiol, and butanediol), carbohydrates (for example, hyaluronic acid and trehalose), aromatic compounds (for example, example, aromatic amines, vanillin, and indigo), vitamins, and cofactors (as described in Ullmann's Encyclopedia of Industrial Chemistry, vol.A27, "Vitamins", pp. 443-613 (1996 VCH: Weinheim and references therein).; and Ong, A.S., Niki, E. & Packer, L. (1995) "Nutrition, Lipids, Health, and Disease" Abstracts of the UNESCO / Confederation of Scientific and Technological Associations in Malaysia, at the Society for Free Radical Research-Asia, which had verification from September 1 to 3 from 1994 in Penang, Malaysia, AOCS Press, (1995)), enzymes, polyketides (Cane et al (1998) Science 232: 63-68), and all other chemical agents described in Gutcho 1983) Chemicals by Fermentation, Noyes Data Corporation, ISBN: 0818805086 and references mentioned there. The metabolism and uses of some of these fine chemicals are further explained below. A. Metabolism and use of amino acids Amino acids comprise the basic structural units of all proteins and as such are essential for normal cellular functioning in all organisms. The term "Amino Acids" is known in the art. The proteinogenic amino acids, of which there are 20 species, serve as structural units for proteins, where they are linked by peptide bonds, while the non-proteinogenic amino acids (hundreds of them are known) are not normally found in proteins (see Ulmann's Encyclopedia of Industrial Chemistry, volume A2, page 57-97 VCH: Weinheim (1985)). Amino acids can be found in the optical configuration D or L, even though amino acids in the L configuration are generally the only type found in naturally occurring proteins. The biosynthetic and degradation pathways of each of the 20 proteinogenic amino acids have been well characterized in both prokaryotic and eukaryotic cells (see, for example, Stryer, L. Biochemistry, 3rd edition, pages 578-590 (1988)) . The "essential" amino acids (histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan and valine) named as they are generally a nutritional requirement due to the complexity of their biosynthesis, they are easily converted by simple biosynthetic pathways into the II non-essential amino acids "remaining" .Alanine, arginine, asparagine, aspartate, cysteine, glutamate, glutamine, glycine, proline, serine and tyrosine). Higher animals retain the ability to synthesize some of these amino acids, but essential amino acids must be supplied from the diet for normal protein synthesis to occur. Apart from their function in the biosynthesis of proteins, these amino acids are interesting chemical agents per se, and it has been found that many of them have several applications in the food industries for humans and animals, the chemical industry, the food industry, cosmetics, agriculture as well as pharmaceutical industry. Lysine is an important amino acid in nutrition not only in humans but also in monogastric animals such as birds and pigs. Glutamate is most often used as a flavoring additive (monc-sodium glutamate, MSG) and is widely used in the food industry, as well as aspartate phenylalanine, glycine and cysteine. The glycine L-methionine and tryptophan are all used in the pharmaceutical industry. Glutamine, valine, leucine, isoleucine, histidine, arginine, proline, serine and alanine are used both in the pharmaceutical industry and in the cosmetics industry. Threonine, tryptophan and methionine D / L are common additives for food. (Leuchtenberger, W. (1996) Amino Acids Technical Production and Use, page 466-502 in Rehm et al. (eds.) Biotechnology vol. 6, chapter 14a. VCH: Weinheim). In addition, these amino acids are useful as precursors for the synthesis of synthetic amino acids and proteins, such as N-acetylcysteine, S-carboxymethyl-L-cysteine, (S) -5-hydroxytryptophan, and others described in Ulmann's Encyclopedia of Industrial Chemistry, vol. . A2, pages 57-9", VCH: Weinheim, 1985.

The biosynthesis of these natural amino acids in organisms capable of producing them such as bacteria has been well characterized (for a review of bacterial amino acid biosynthesis and regulation thereof, see Umbarger, HE (1978) Ann. Rev. Biochem. 47: 533-606). Glutamate is synthesized by the reductive amination of a-ketoglutarate, an intermediate product in the citric acid cycle. Glutamine, proline and arginine are subsequently produced, each one, from glutamate. Serine biosynthesis is a three-step process that starts with 3-phosphoglycerate (an intermediate product in glycolysis), and results in this amino acid after oxidation, transamination, and hydrolysis. Both cysteine and glycine are produced from serine; the former by condensation of homocysteine with serine, and the latter by the transfer of the β-side chain carbon atom to tetrahydrofolate, in a reaction catalyzed by serine transhydroxymethylase. Phenylalanine and tyrosine are synthesized from the precursors of the glycolytic pathway and phosphate of pentose, erythro-4-phosphate and phosphoenolpyruvate in a 9-step biosynthetic pathway that differs only in the 2 final steps after prephenate synthesis. The, triptofanc is also produced from these 2 initial molecules, but its synthesis is a way of 11 steps. Tyrosine can be synthesized from phenylalanine in the reaction catalyzed by phenylalanine hydroxylase. Aianine, valine and leucine are all biosynthetic products of pyruvate, the final product of glycolysis. Aspartate is formed from oxaloacetate, an intermediate product of the citric acid cycle. Asparagine, methionine, threonine and lysine are each produced by the conversion of aspartate. Isoleucine is formed from threonine. A complex line of 9 steps results in the production of histidine from 5-phosphoribosyl-1-pyrophosphate, an activated sugar. Amino acids in excess of the protein synthesis needs of the cell can not be stored and are degraded to the contrary to provide intermediates for the metabolic pathways of the cells (See Stryer, L. Biochemistry 3rd edition, chapter 21"Amino Acid Degradation and the Urea Cycle" pages 495-516 (1988)). Even when the cell can convert unwanted amino acids into useful metabolic intermediates, the production of amino acids is expensive in terms of energy, precursor molecules and the enzymes needed to synthesize them. It is therefore not surprising that amino acid biosynthesis is regulated by the inhibition of feedback where the presence of a particular amino acid serves to slow down or completely suspend its own production (for a review of the feedback mechanisms in the biosynthetic pathways of amino acids, see Stryer, L. Biochemistry, 3rd edition, chapter 24: "Biosynthesis of Amino Acids and Heme" pages 575-600 (1988)). Thus, the production of any particular amino acid is limited by the amount of this amino acid present in the cell. B. Vitamin metabolism as cofactors and nutraceuticals, and uses Vitamins, cofactors and nutraceuticals comprise another group of molecules that higher animals have lost the ability to synthesize and therefore must ingest, even when they are easily synthesized by other organisms such as bacteria . These molecules are either bioactive substances themselves or precursors of biologically active substances that can serve as electron carriers or intermediates in various metabolic pathways. Apart from their nutritional value, these compounds also have a significant industrial value as coloring agents, antioxidants and catalysts or other processing aids. (For a discussion of the structure, activity, and industrial applications of these compounds, see, for example, Ullman's Encyclopedia of Industrial Chemistry, "Vitamins" vol.A27, pages 443-613, VCH: Weinheim, 1996.). The term "vitamin" is known in the art and includes nutrients that are required by an organism for normal functioning, but which said organism can not synthesize alone. The group of vitamins can include cofactors and nutraceuticals. The term "cofactors" includes non-proteinaceous compounds required for normal enzymatic activity to occur. Such compounds may be organic and inorganic; the cofactor molecules of the invention are preferably organic. The term "nutraceutical" includes dietary supplements that have health benefits in plants and animals, particularly humans. Examples of such molecules are vitamins, antioxidants, and also certain lipids (for example, polyunsaturated fatty acids). The biosynthesis of these molecules in organisms capable of producing them such as bacteria has been widely characterized (Ullman's Encyclopedia cf Industrial Chemistry, "Vitamins" vol A27, pages 443-613, VCH: Weinheim, 1996, Michal G. (1999) Biochenicai Pathways: An Atlas of Biochemistry and Molecular Biology, John Wiley &Sons; Ong, AS, Niki, E. &Packer, L. (1995) "Nutrition, Lipids, Health, and Disease" Abstracts of UNESCO / Confederation of Scientific and Technological Associations in Malaysia, and the Society for Free Radical Research - Asia, which was held from September 1 to 3, 1994 in Penang, Malaysia, AOCS Press: Champaing, IL X, 374 S). Thiamine (vitamin Bx) is produced by the chemical coupling of portions of pirinidine and tlazol. Riboflavin (vitamin B2) is synthesized from guanosine-5'-triphosphate (GTP) and ribose-5'-phosphate. Riboflavin, in turn, is used for the synthesis of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAZ). The family of compounds known collectively as "vitamin B" (for example pyridoxine, pyridoxamine, pyridoxa-5'-phosphate, and the pyridoxine hydrochloride used commercially) are all derived from the common structural unit, 5-hydroxy-6-methylpyridine. Pantothenate (pantothenic acid), (R) - (+) - N- (2,4-dihydroxy-3, 3-dimethyl-l-oxobutyl) -β-alanine) can be produced by chemical synthesis or by fermentation. The final steps in the pantotenatc biosynthesis consist of ß-alanma and pantic acid-driven ATP condensation. The enzymes responsible for the steps of biosynthesis for conversion to pantoic acid in β-alanine and for the condensation of pantothenic acid are known. The metabolically active form of pantothenate is Ceenzyme A, for which biosynthesis is carried out in 5 enzymatic steps. Pantothenate, pyridoxal-5'-phosphate, cysteine and ATP are the precursors of Coenzyme A. These enzymes not only catalyze the formation of pantothenate but also the production of pantoic acid- (R), (R) -pantolactone, (R) -pantenol (provitamin B?), pantethein (and derivatives) and coenzyme A.

The biosynthesis of biotin from the precursor molecule of pimeloil-CoA in microorganisms has been studied in detail and several of the genes involved have been identified. It has also been found that many of the corresponding proteins were involved in the synthesis of Fe groups and are members of the nifS class of proteins. Lipoic acid is derived from octanoic acid, and serves as a coenzyme in energy metabolism, where it becomes part of the pyruvate dehydrogenase complex and the a-ketoglutarate dehydrogenase complex. Folates are a group of substances that are derived from folic acid, which in turn is derived from L-glutamic acid, p-aminc-benzoic acid and 6-ethylpterin. The biosynthesis of folic acid and its derivatives, starting from the metabolism intermediates guanosine-5 'triphosphate (GTP), L-glutamic acid and p-aminobenzoic acid has been studied in detail in certain microorganisms. Corrinoids (such as cobalamines and especially Bi2 vitamins) and porphyrins belong to a group of chemicals characterized by a tetrapyrol ring system. The biosynthesis of vitamin B 2 is complex enough that it has not been fully characterized to date but many of the enzymes and substrates involved are now known. Nicotinic acid (nicotinate) nicotinamine are peridin derivatives that are also known as "niacin". Niacin is the precursor of the important coenzymes NAD (nicotinamide adenine dinucleotide) and NADP (nicotinamide adenine dinucleotide phosphate) and their reduced forms. The large-scale production of these compounds is based largely on chemical synthesis without cells, even though some of these chemical agents have also been produced by large-scale cultivation of microorganisms such as riboflavin, vitamin B, pantothenate and biotin. Only B: is produced only by fermentation, due to the complexity of its synthesis. In vitro methodologies require significant contributions in terms of materials and time, often at a high cost. C. Metabolism of purine, pyrimidine, nucleoside and nucleotides, and uses The genes for the metabolism of purine and pyrimidine and their corresponding proteins are important targets for the therapy of tumor diseases and viral infections. The terms "purine" or "pyrimidine" include the nitrogenous bases that constitute the nucleic acids, coenzymes and nucleotides. The term "nucleotide" includes (Basic structural units of nucleic acid molecules, consisting of a nitrogenous base, a pentose sugar (in the case of RNA, sugar is ribose, in the case AD, sugar is D-deoxyribose), and phosphoric acid. the term "nucleoside" includes molecules which serve as precursors to nucleotides, but which have no portion of phosphoric acid having nucleotides. by inhibiting the biosynthesis of these molecules or their mobilization for fomar nucleic acid molecules, It is possible to inhibit the synthesis of RNA and DNA, by inhibiting this activity in a targeted manner towards cancer cells, the ability of tumor cells to divide and replicate can be inhibited, and there are - nucleotides that do not form nucleic acid molecules, but which serve as energy stores (ie AMP) or as coenzymes (ie FAD and NAD) Several publications have described the use of these agents These are indicative for these medical indications, through the influence of purine and / or pyrimidine metabolism (for example Christopherson, R.I. and Lycns, S.D. (1990) "Potent inhibitors of de novo pyrimidine and purine biosynthesis as chemotherapeutic agents." Med. Res. Reviews 10: 505-548). Studies of enzymes involved in the metabolism of purine and pyrimidine have been focused on the development of new drugs which can be used, for example, as immunosuppressants or anti-proliferation (Smith, JL, (1995) "Enzymes in nucleotide synthesis agents. "Curr. Opin Struct. Biol. 5: 752-757; (1995) Biochem Soc. Transact. 23: 877-902). However, the bases of purine and pyrimidine, nucleosides and nucleotides have other uses: as intermediates in the biosynthesis of several fine chemicals (such as, for example, thiamine, S-adenosyl-methionine, folates, or riboflavin), as energy vehicles for the cell (for example, ATP or GMP) and for chemical agents themselves, commonly used as flavor enhancers (such as IMP or GMP) or for various medical applications (see, for example, Kuninaka, A. ( 1996) Nucleotides and Related Compounds in Biotechnology vol 6, Rehm et al., Eds VCH: Weinheim, pages 561-612). Likewise enzymes involved in purine, pyrimidine, nucleoside or nucleotide metabolism increasingly serve as targets with which chemical agents for the protection of crops are developed, including fungicides, herbicides and insecticides. The metabolism of these compounds in bacteria has been characterized (for review see, for example, Zalkin, H. and Dixon, JE (1992) "de novo purine nucleotide biosynthesis", in: Progress in Nucleic Acid Research and Molecular Biology, vol. 42, Academic Press: pages 259-287 and Michal, G. (1999) "Nucleotides and Nucleosides", chapter 8 in: Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology, Wiley: New York). The metabolism of purine has been the subject of intense research and is essential for the normal functioning of the cell. An affected metabolism of the purine in higher animals can cause severe diseases such as gout. The purine nucleotides are synthesized from riboea-5'-phosphate, in the series of passages through the intermediate inosine-5'-phosphate (IMP), which results in the production of guanosine-5 '-monophosphate ( GMP) or adenosine-5'-monophosphate (AMP), for which the triphosphate forms used as nucleotides are easily formed. These compounds are also used as energy stores in such a way that their degradation provides energy for many different biochemical processes in the cell. The biosynthesis of pyrimidine proceeds through the formation of uridine-5'-monophosphate (UMP) from ribose-5-fc = fato. In turn UMP is converted to histidine-5'-triphosphate (CTP). The deoxy forms of all of these nucleotides are produced in a one-step derivatization reaction from the ribose diphosphate form of the nucleotide to the deoxyribose diphosphate form of the nucleotide. When phosphorylation is carried out, these molecules are able to participate in the synthesis of DNA. D. Trehalose metabolism and uses Trehalose consists of two molecules of glucose, linked in a bond to, a-l, l. It is commonly used in the food industry as a sweetener, an additive for dried or frozen foods, and in beverages. However, it also has applications in the pharmaceutical industry, the cosmetics industry and the biotechnology industry (see, for example Nishi oto et al. (1998), North American Patent No. 5,759,610, Singer, MA and Lindquist, S (1998) Trends Biotech 16: 460-467; Paiva, CL and Panek, AD (1996) Biotech Ann. Rev. 2: 293-314; and Shiosaka, M. (1997) J. Japan 172: 97-102 ). Trehalose is produced by enzymes of numerous microorganisms and is released naturally in the surrounding environment, from which it can be collected using methods known in the art. II. MEMBRANE BIOSYNTHESIS AND TRANSMEMBRANE TRANSPORT Cell membranes have several functions in a cell. First and foremost, a membrane differentiates the content of a cell from the surrounding environment, thus providing integrity to the cell. Membranes can also serve as barriers to the influx of dangerous or unwanted compounds, and also to the efflux of desired compounds. Cell membranes are by nature impervious to the non-facilitated diffusion of hydrophilic compounds such as proteins, water molecules and ions due to their structure: a double layer of lipid molecules in which the polar head groups face outwards ( towards the outside and towards the inside of the cell, respectively) and non-polar tails face inward at the center of the bending layer, forming a hydrophobic core (for a general discussion of membrane structure and function, see Gennis, RB (1989) Biomembranes, Molecular Structure and Function , Springer, Heidelberg). This barrier allows the cells to maintain a relatively higher concentration of desired compounds and a relatively lower concentration of undesired compounds than is contained within the surrounding medium, since the diffusion of these compounds is effectively blocked by the membrane. However, the membrane also presents an effective barrier to the importation of desired compounds and the export of residual molecules. To overcome this difficulty, cell membranes incorporate many types of transporter proteins that can facilitate transmembrane transport of different types of compounds. There are two general classes of these transporter proteins: pores or channels and transporters. The former are integral membrane proteins, sometimes protein complexes, which form a regulated orifice through the membrane. This regulation, or "gate formation", is generally specific for the molecules to be transported through the pore or channel, making these transmembrane constructs selectively permeable to a specific class of substrates.; For example, a pot channel is constructed in such a way that only ions that have a charge and size similar to the charge and size of the potassium can cross. Channel and pore proteins tend to have discrete hydrophobic and hydrophilic domains, such that the hydrophobic face of the protein can associate with the inner part of the membrane while the hydrophilic face coats the inner part of the channel, thus providing a hydrophilic environment protected through which the selected hydrophilic molecule can pass. Many pores / channels of this type are known in the art, including pores / channels for potassium, calcium, sodium, and chloride ions. This system mediated by pores and facilitated diffusion channels is limited to very small molecules, such as ions, because pores or channels large enough to allow the passage of whole proteins by facilitated diffusion could not prevent the passage of smaller hydrophilic molecules as well. The transport of molecules by this process is sometimes referred to as "facilitated diffusion" since the driving force of a concentration gradient is required for transport to occur. Permeases also allow a facilitated diffusion of larger molecules, such as glucose or other sugars, in the cell when the concentration of these molecules on one side of the membrane is greater than the concentration of these molecules on the other side of the membrane. (It is also known as "uniporte"). In contrast to pores or channels, these integral membrane proteins (which often have 6-14 helices spanning the membrane) do not form open channels through the membrane but instead bind with the target molecule on the surface of the membrane and then subjected to a conformational change such that the target molecule is released on the opposite side of the membrane. However, cells often require the import or export of molecules against the existing gradient of concentrations ("active transport"), a situation in which facilitated diffusion can not occur. There are two general mechanisms used by the elulas for a membrane transport of this type: simporte c antiporte, and transport coupled with energy as for example transport mediated by ABC transporter proteins. The simporte and antiport systems couple the movement of two different molecules through the nembrana (through permeases that have two separate binding sites for the two different molecules); in: the simporte, both molecules are transported in the same direction, while in the antiport, one molecule is imported while the other molecule is exported. This is possible from an energy perspective since one of the two molecules moves in accordance with a concentration gradient, and this favorable event from an energy perspective is allowed only through the concomitant movement of a desired compound against the predominant concentration gradient. . Individual molecules can be transported across the membrane against the concentration gradient in an energy driven process, such as in the process used by the ABC transporters. In this system, the transport protein located in the membrane has an ATP binding cassette; Upon binding of the target molecule, ATP is converted to ADP + Pi, and the resulting release of energy is used to drive the movement of the white molecule towards the opposite side of the membrane, facilitated by the transporter. For more detailed descriptions of all these transport systems, see: Bamberg, E. et al. (1993, "Charge transport of ion pumps on lipid bilayer membranes", Q. Rev. Biophys 26: 1-25, Findlay, JBC (1991) "Structure and function in membrane transport systems", Curr. Opin. Struct. Biol 1: 804-810; Higgins, C.F. (1992) "ABC transporters from microorganisms to man", Ann Rev. Cell Biol. 8: 67-113; Gennis, R.B. (1989) "Pores, Channels and Transporters", in: Biomembranes, Molecular Structure and Functions, Springer, Heidelberg, pages 270-322; and Nikaido, H. and Saier, H. (1992) "Transport proteins in bacteria: common themes in their design", Science 258: 93 ^ -942, and references contained in each of these references. Membrane synthesis is a well-known process that involves numerous components, the most important of which refers to lipid molecules. The synthesis of lipids can be subdivided into two parts: the synthesis of fatty acids and their attachment to sn-glycerol-3-phosphate, and the addition or modification of a polar head group. Typical lipids used in bacterial membranes include phospholipids, glycolipids, sphingolipids, and phosphoglycerides. The synthesis of fatty acids begins with the conversion of acetyl CoA either in malonyl CoA by acetyl CoA carboxylase, or in acetyl ACP by acetyltransacilasa. After a condensation reaction, these two product molecules together form acetoacetyl-ACP, which is converted through a series of condensation, reduction and dehydration reactions to provide a saturated fatty acid molecule having a desired chain length. The production of unsaturated fatty acids from such molecules is catalyzed by specific desaturases either aerobically, with the help of molecular oxygen, or anaerobically (for reference in terms of fatty acid synthesis, see FC Neidhardt et al. al. (1996) E. coli and Salmonella, ASM Press: Washington, DC pp. 612-636 and references contained there, Lengeler et al. (eds) (1999) Biology of Procaryotes, Thieme: Stuttgart, New York, and references contained there, and Magnuson, K. et al., (1993) Microbiological Reviews 57: 522-542, and references contained therein). The cyclopropane fatty acids (CFA) are synthesized by a specific CFA-synthase using SMA as a co-substrate. Branched chain fatty acids are synthesized from branched chain amino acids that are deaminated to provide branched chain 2-oxo acids (see Lengeler et al., Eds. (1999) Biology of Procaryotes. Thieme: Stuttgart, New York, and references contained there). Another essential step in the synthesis of lipids is the transfer of fatty acids in the polar head groups by, for example, glycerol-phosphate-acyltransferases. The combination of several precursor molecules and biosynthetic enzymes results in the production of different fatty acid molecules, which has a profound effect on the composition of the membrane. III. ELEMENTS AND METHODS OF THE INVENTION The present invention is based, at least in part, on the discovery of novel molecules, which are known herein as MCT protein and nucleic acid molecules, which control the production of cellular membranes in C. glutamicum and they govern the movement of molecules through such membranes. In one embodiment, MCT molecules participate in the metabolism of compounds that are necessary for the construction of cell membranes in C. glutamicum, or in the transport of molecules through these membranes. In a preferred embodiment, the activity of the MCT molecules of the present invention to regulate the production of membrane components and the transport of membranes has an impact on the production of a fine chemical desired by this organism. In a particularly preferred embodiment, the MCT molecules of the invention are modulated in terms of their activity, such that metabolic pathways of C. glutamicum that regulate the MCT proteins of the invention are modulated in terms of yield, production and / or or efficiency of production 'and in such a way that the transport of compounds through the membranes is altered in terms of their efficiency, which modulates either directly or indirectly the performanceproduction, and / or production efficiency of a fine chemical desired by C. glutamicum. The term "MCT protein" or "MCT polypeptide" includes proteins that participate in the metabolism of compounds that are necessary for the construction of cell membranes in G. glutamicum, or in the transport of molecules through these membranes. Examples of MCT proteins include the proteins encoded by the MCT genes presented in Table 1 or by the odd number SEQ ID NOs. The terms "MCT gene" or "MCT nucleic acid sequence" include nucleic acid sequences encoding the MCT protein, which consist of a coding region and also the corresponding non-translated 5 'and 3' sequence regions. Examples of MCT genes include the genes presented in Table 1. The terms "production" or "productivity" are known in the art and include the concentration of the fermentation product (eg, the desired fine chemical) formed within a certain time. given and with a given fermentation volume (for example, kg of product per hour per liter). The term "production efficiency" includes the time required to achieve a particular level of production (for example, the time it takes for the cell to achieve a particular rate of production of a fine chemical). The term "yield" or "product / carbon yield" is known in the art and includes the efficiency of the conversion of the carbon source into the product (ie, fine chemical). This is generally written, for example, kg of product per kg of carbon source. By increasing the yield or production of the compound, the amount of molecules recovered or the molecules recovered useful from this compound in a given amount of culture in a given period of time is raised. The terms "biosynthesis" or a "biosynthetic pathway" are known in the art and include the synthesis of a compound, preferably an organic compound, by a cell from intermediates in what can be a highly multistep process regulated. The terms "degradation" or "a degradation pathway" are known in the art and include the decomposition of a compound, preferably an organic compound, by a cell into degradation products (in general terms, smaller or less complex molecules) in what can be a multi-stage and highly regulated process. The term "metabolism" is known in the art and includes all the biochemical reactions that are carried out in an organism. The metabolism of a particular compound then comprises (i.e. the metabolism of an amino acid such as glycine) the biosynthetic, global modification and degradation pathways in the cell that are related to this compound. In another embodiment, the MCT molecules of the invention can modulate the production of a desired molecule, such as a fine chemical, in a microorganism such as, for example, C. glutamicum. There are numerous mechanisms through which the alteration of a MCT protein of the present invention can directly affect the yield, production, and / or production efficiency of a fine chemical from a strain of C. glutamicum that incorporates a protein altered of this type. These MCT proteins involved in the export of chemical molecules from the cell can be increased in their number or in terms of their activity in such a way that larger amounts of these compounds are secreted into the extracellular medium, starting from which are recovered more easily. Similarly, these MCT proteins involved in the importation of nutrients necessary for the biosynthesis of one or more fine chemicals (for example, phosphate, sulfate, nitrogen compounds, etc.) can be increased in number or activity of such that these precursor compounds, co-factors or intermediates present a higher concentration within the cell. In addition, fatty s and lipids themselves are desirable fine chemicals; by optimizing the activity or by increasing the number of one or more MCT proteins of the invention involved in the biosynthesis of these compounds, or by affecting the activity of one or more MCT proteins involved in the degradation of these compounds, it may be possible to increase the yield, production and / or production efficiency of fatty acid and lipid molecules from C. glutamicum. The mutagenesis of one or more MCT genes of the invention can also result in MCT proteins having altered activities which has an indirect impact on the production of one or more desired fine chemicals from C. glutamicum. For example, MCT proteins of the invention involved in the export of residual products can be increased in number or activity in such a way that the normal metabolic residues of the cell (possibly increased in amount due to the overproduction of the fine chemical desired) are efficiently exported before they cause damage to nucleotides and proteins within the cell (which would decrease the viability of the cell) or before they interfere with biosynthetic pathways of fine chemicals (which could decrease yield, production, or production efficiency of the desired fine chemical). In addition, the relatively large intracellular amounts of the desired fine chemical can themselves be toxic to the cell, such that by increasing the activity or number of transporters capable of exporting this compound from the cell, the viability can be increased. of the cell in culture, which in turn causes the presence of a greater number of cells in the culture that produce the desired fine chemical. The MCT proteins of the present invention can also be manipulated such that relative amounts of different lipid and fatty acid molecules are produced. This can have a profound effect on the composition of the lipids of the cell membrane. Since each type of lipid has different physical properties, an alteration of the lipid composition of a membrane can significantly alter the fluidity of the membrane. Changes in the fluidity of the membrane can have an impact on the transport of molecules through the membrane, as well as on the integrity of the cell, both having a profound effect on the production of fine chemicals from C. glutamicum in large-scale fermentative culture. The isolated nucleic acid sequences of the present invention are contained within the genome of a strain of Corynebacterium glutamicum available from the American Type Culture Collection, which received the designation ATCC 13032. The nucleotide sequence of the MCT cDNAs of C. glutamicum Isolated and the predicted amino acid sequences of the MCT proteins of C. glutamicum are shown in the Sequence List as SEQ ID NOs of odd number and as SEQ ID NOs of even number, respectively. Computerized analyzes were performed to classify and / or identify the nucleotide sequences as sequences that encode proteins involved in the metabolism of cell membrane components or proteins involved in the transport of compounds through such membranes. The present invention also relates to proteins having an amino acid sequence substantially homologous with an amino acid sequence of the invention (for example, the sequence of a SEQ ID NO of even number from the Sequence List). As used herein, a protein having an amino acid sequence substantially homologous to a selected amino acid sequence has a homology of at least about 50% with the selected amino acid sequence, eg, the entire selected amino acid sequence. A protein having an amino acid sequence substantially homologous to a selected amino acid sequence can also have at least a homology of about 50-60%, preferably at least about 60-70%, and more preferably at least about 70-80%, 80-90%, or 90-95%, and with special preference at least about 96%, 97% , 98%, 99% or more with the selected amino acid sequence. The MCT protein or a biologically active portion or fragment thereof of the present invention may participate in the metabolism of compounds that are necessary for the construction of cell membranes in C. glutamicum, or in the transport of molecules through these. Membranes may or may have one or more of the activities presented in Table 1. Various aspects of the present invention are described with additional details in the following subsections. A. Isolated Nucleic Acid Molecules One aspect of the invention relates to isolated nucleic acid molecules encoding MCT polypeptides or biologically active portions thereof, as well as to nucleic acid fragments sufficient to be used as hybridization probes or as primers for identification or amplification of nucleic acid encoding MCT (eg MCT DNA). As used herein, the term "nucleic acid molecule" includes DNA molecules (e.g., cDNA or genomic DNA) and RNA molecules (e.g., mRNA and DNA or RNA analogs generated using nucleotide analogs. untranslated sequence located both at the 3 'end and the 5' end of the coding region of the gene: at least about 100 nucleotides of sequence upstream of the 3 'end of the coding region and at least 20 nucleotides of sequence downstream of the 3 'end of the coding region of the gene The nucleic acid molecule can be single stranded or double stranded, but is preferably double stranded DNA An "isolated" nucleic acid molecule is a molecule. which is separated from other nucleic acid molecules present in the natural source of the nucleic acid.Preferably, an "isolated" nucleic acid is free of flanking sequence naturally the nucleic acid (i.e., sequences located at the 5 'and 3' ends of the nucleic acid) in the genomic DNA of the organism from which the nucleic acid is derived, for example, in various embodiments, the nucleic acid molecule Isolated MCT can contain less than about 5 kb, 4 kb, 3 kb, 2 kb, 1 kb, 0.5 kb, or 0.1 kb of nucleotide sequences that naturally flank the nucleic acid molecule in the genomic DNA of the starting cell from which the nucleic acid is derived (for example, a cell of C. glutamicum). In addition, an "isolated" nucleic acid molecule, such as for example the DNA molecule, can be substantially free of other cellular material, or culture medium when produced by recombinant techniques, or chemical precursors or other chemical agents when synthesized Chemically .- A nucleic acid molecule of the present invention, for example, a nucleic acid molecule having a nucleotide sequence of a SEQ ID NO: odd number of the Sequence List, or a portion thereof, can be isolated using standard molecular biology techniques and the sequence information provided here. For example, an MCT DNA of, C. glutamicum can be isolated from a C. glutamicum library using all or a portion of one of the sequences SEQ ID NO: odd number from the Sequence List as a probe of hybridization and standard hybridization techniques (for example, in accordance with that described in Sambrook, J., Fritsh, EF and Maniatis, T. Molecular Cloning; A Laboratory Manual 2nd. Ed. Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989).

In addition, a nucleic acid molecule that encompasses all or a portion of one of the nucleic acid sequences of the invention (eg, a SEQ ID NO of odd number) can be isolated by polymerase chain reaction using oligonucleotide primers. initiated based on this sequence (e.g., the nucleic acid molecule encompassing all or a portion of one of the nucleic acid sequences of the invention (e.g., an SEQ ID NO of odd number from the Sequence List) it can be isolated by polymerase chain reaction using oligonucleotide primers designed based on said sequence). For example, mRNA can be isolated from normal endothelial cells (for example by the guanidinium thiocyanate extraction procedure of Chirgwin et al (1979) Biochemistry 18: 5294-5299) and DNA can be prepared using reverse transcriptase (e.g. Moloney MLV reverse transcriptase available from Gibco / BRL, Bethesda, MD or AMV reverse transcriptase available from Seikagaku America, Inc., St Petersburg, FL). Synthetic oligonucleotide primers for polymerase chain reaction amplification can be designed based on one of the nucleotide sequences shown in the Sequence Listing. A nucleic acid of the invention can be amplified using cDNA or alternatively genomic DNA as annealed and appropriate oligonucleotide primers according to standard polymerase chain reaction amplification techniques. The nucleic acid amplified in this way can be cloned into an appropriate vector and characterized by analysis of DNA sequences. In addition, oligonucleotides corresponding to a nucleotide sequence of MCT can be prepared by standard synthetic techniques, for example, using an automated DNA synthesizer. In a preferred embodiment, an isolated nucleic acid molecule of the invention comprises one of the nucleotide sequences shown in the Sequence List. The nucleic acid sequences of the invention, in accordance with that presented in the Sequence List, correspond to the MCT DNAs of Corynebacterium glutamicum of the invention. This DNA comprises sequences encoding MCT proteins (ie, the "coding region", indicated in each SEQ ID NO sequence of odd number in Sequence List) as well as the 5 'untranslated sequences and 3' untranslated sequences, indicated also in each SEQ ID NO: odd number in the Sequence List. Alternatively, the nucleic acid molecule can comprise only the coding region of any of the nucleic acid sequences of the Sequence List.

For the purposes of this application, it will be understood that each of the nucleic acid and amino acid sequences presented in the Sequence List has an identification number RXA, RXN, RXS or RXC having the designation 5"RXA", "RXN" , "RXS" or "RXC" followed by 5 digits (for example, RXA02099, RXN03097, RXS00148, or RXC01748). Each of the nucleic acid sequences comprises up to three parts: an upstream region of 5 ', a coding region and a downstream region. Each of these * 10 three regions is identified by the same designation RXA, RXN, RXS or RXC to avoid confusion. The expression "one of the odd number sequences of the Sequence List" therefore refers to any nucleic acid sequence in the Sequence List which may also be 15 distinguished by its different RXA, RXN, RXS or RXC designations. The coding region of each of these sequences is translated into a sequence of corresponding amino acids that are also presented in the sequence listing, as an even number SEQ ID NO: 20 after the corresponding nucleic acid sequence. For example, the coding region for RXA03097 is presented in SEQ ID NO: 1 while the amino acid sequence encoding it is presented as SEQ ID NO: 2. The nucleic acid sequences of the invention are identified by the The same designations are RXA, RXN, RXS or RXC as the amino acid molecules they encode, so that they can be easily correlated. For example, the designated amino acid sequences RXA02099, RXN03097, RXS00148, and RXC01748 are translations of the coding regions of the nucleotide sequences of nucleic acid molecules RXA02099, RXN03097, RXS00148 and RXC01748, respectively. The correspondence between the nucleotide and amino acid sequences RXA, RXN, RXS, and RXC of the invention and their SEQ ID NOs. Assays are presented in Table 1. For example, as shown in Table 1, the nucleotide sequence of RXA00104 is SEQ ID NO: 5, and the amino acid sequence of RXA00104 is SEQ ID NO: 6. Several of the genes of the invention are "genes designated with the letter F". A gene designated with the letter F includes the genes presented in Table 1, which have an "F" in front of the designations RXA, RXN, RXS, or RXC. For example, SEQ ID NO: 11, designated, according to what is indicated in Table 1, as "F RXA02581", is a gene designated with the letter F, as they are SEQ ID NOs: 31, 33 and 43 (designated in table 1 as "F RXA02487", "F RXA02490", and "F RXA02809", respectively). In one embodiment, the nucleic acid molecules of the present invention are not contemplated as including the molecules compiled in Table 2. In the case of the dapD gene, a sequence for this gene was published in Wehrmann, A., et al. (1998) J. Bacteriol. 180 (12); 3159-3165. However, the sequence obtained by the inventors of the present application is significantly longer than the published version. It is believed that the published version was based on an incorrect initial codon, and therefore represents only a fragment of the actual coding region. In another preferred embodiment, an isolated nucleic acid molecule of the present invention comprises a nucleic acid molecule that is a complement to one of the nucleotide sequences of the invention (for example a sequence of a SEQ ID NO: the Sequence List) or a part of it. A nucleic acid molecule that is complementary to one of the nucleotide sequences of the invention is a molecule that is sufficiently complementary to one of the nucleotide sequences shown in the Sequence List (e.g., the sequence of a SEQ ID NO: of odd number) in such a way that it can hybridize with one of the nucleotide sequences of the invention, thereby forming a stable duplex. In another preferred embodiment of the invention, an isolated nucleic acid molecule of the present invention comprises a nucleotide sequence having a homology level of at least about 50%, 51%, 52%, 53%, 54%, 55 %, 56%, 57%, 58%, 59% or 60%, preferably at least approximately 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70%, more preferably at least about 71%, 72%, 73% 74%, 75%, 76%, 77%, 78%, 79%, or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89% or 90%, or 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or more with a 5 nucleotide sequence of the invention (for example a sequence of SEQ ID NO: odd number of the Sequence List) or a part thereof. Intermediate identity ranges and values in relation to the ranges mentioned above (a level of identity of 70-90% or 80-95%) 10 also contemplate within the framework of the present invention for example ranges of identity values that use a combination of any of the values mentioned above as upper and / or lower limits are also included. In a further preferred embodiment a molecule The isolated nucleic acid of the invention comprises a nucleotide sequence that hybridizes, for example, hybridizes under stringent conditions to one of the nucleotide sequences of the invention, or a portion thereof. In addition, the nucleic acid molecule of the invention can Comprise only a portion of the coding region of the sequence of one of the SEQ ID NOs of the odd number of the Sequence List, eg, a fragment that can be used as a probe or primer or a fragment that encodes a portion biologically active of a protein 25 MCT. The nucleotide sequences determined from the cloning of MCT genes from C. glutamicum in the generation of probes and primers designed to be used to identify and / or clone MCT homologs in other cell types and organisms, as well as MCT homologs from other Corinebacteria or related species. Probes / primers typically comprise substantially purified oligonucleotides. The oligonucleotide typically comprises a nucleotide sequence region that hybridizes under stringent conditions to at least about 12, preferably about 25, more preferably, about 40, 50 or 75 consecutive nucleotides of a sense strand of one of the nucleotide sequences of the invention (for example, a sequence of one of the SEQ ID NOs of the odd number of the Sequence List), an antisense sequence of one of these sequences, or naturally occurring mutants thereof. Initiators based on a nucleotide sequence of the invention can be used in polymerase chain reactions to clone MCT homologs. They are the passages in the nucleotide sequences of MCT can be used to detect transcripts or genomic sequences that encode the same protein or a homologous protein. In preferred embodiments, the probe further comprises a label group attached thereto as for example, the label group can be a radioisotope, a fluorescent compound, an enzyme, an enzyme cofactor. Such probes can be used as part of a set of diagnostic test elements to identify cells that erroneously express a MCT protein as for example by measuring a level of nucleic acid encoding MCT in a sample of cells, such as for example , the detection of MCT mRNA levels or the determination of whether a genomic MCT gene has been mutated or removed. In one embodiment, the nucleic acid molecule of the present invention encodes a protein or part thereof that includes an amino acid sequence that is sufficiently homologous with an amino acid sequence of the invention (eg, a sequence of a SEQ ID NO. even number of the Sequence List) in such a way that the protein or portion thereof retains the ability to participate in the metabolism of compounds necessary for the construction of cell membranes in C. glutamicum, or in the transport of the molecule through of these membranes. As used herein, the term "sufficiently homologous" refers to proteins or portions thereof that have amino acid sequences that include a minimum number of identical or equivalent amino acid residues (eg, an amino acid residue having an amino acid residue). side chain similar to an amino acid residue in a sequence of one of the even-numbered SEQ ID NOs of the Sequence List) to an amino acid sequence of the invention such that the protein or portion thereof can participate in the metabolism of compounds necessary for the construction of cell membranes in C. glutamicum, or in the transport of molecules through these membranes. Protein members such as membrane component metabolic pathways or membrane transport systems, as described herein, can play a role in the production and secretion of one or more fine chemicals. Examples of such activities are also described here. Thus, "the function of an MCT protein" contributes either directly or indirectly to the yield, production, and / or production efficiency of one or more fine chemicals. Examples of MCT protein activities are presented in Table 1. In another embodiment, the protein has a homology of at least about 50-60%, preferably at least about 60-70%, and most preferably at least about 70-80%, 80-90%, 90-95%, and more preferably at least about 96%, 97%, 98%, 99%, or more with a whole amino acid sequence of the invention (for example a sequence of a SEQ ID NO of even number of the Sequence List). Portions of proteins encoded by the MCT nucleic acid molecules of the invention are preferably biologically active portions of one of the MCT proteins. As used herein, the term "biologically active portion of an MCT protein" is intended to include a portion, eg, a domain / motif, of a MCT protein that participates in the metabolism of compounds necessary for the construction of cell membranes in C. glutamicum, or in the transport of molecules through these membranes, or has an activity in accordance with that set forth in Table 1. To determine whether a MCT protein or a biologically active portion thereof can participate in the metabolism of compounds that are necessary for the construction of cell membranes in C. glutamicum or in the transport of molecules through these membranes, an assay of enzymatic activity can be carried out. Such test methods are well known to those of ordinary skill in the art, in accordance with the details presented in Example 8 of the Examples Section. Additional fragments of nucleic acids encoding biologically active portions of an MCT protein can be prepared by isolating a portion of one of the amino acid sequences of the invention (for example a sequence of a SEQ ID NO: odd number of the Sequence List), which expresses the encoded portion of the MCT protein or peptide (for example, by recombinant expression in vitro) and by evaluating the activity of the encoded portion of the MCT protein or peptide. The invention also encompasses nucleic acid molecules that differ from one of the nucleotide sequences of the invention (eg, a sequence of an SEQ ID NO: odd number from the Sequence List) (and portions thereof) due to the degeneracy of the genetic code and therefore encode the same MCT protein as the protein encoded by the nucleotide sequences of the invention. In another embodiment, an isolated nucleic acid molecule of the present invention has a nucleotide sequence that encodes a protein having an amino acid sequence shown in the Sequence List (eg, an even-numbered SEQ ID NO:). In a further embodiment, the nucleic acid molecule of the invention encodes a full-length C. glutamicum protein substantially homologous with a sequence of > amino acids of the invention (encoded by an open reading frame shown in a SEQ ID NO: odd number from the Sequence List). It will be understood by a person with ordinary knowledge in the art that, in one embodiment, the sequences of the invention are not intended to include the prior art sequences such as the Genbank sequences presented in Tables 2 or 4 available above. of the present invention. In one embodiment, the invention includes nucleotide or amino acid sequences having a percent identity with a nucleotide or amino acid sequence of the invention that is greater than the percent identity of a prior art sequence (a Genbank sequence (or protein encoded by said sequence) presented in Tables 2 or 4). For example, the invention includes a nucleotide sequence having a level of identity that is greater than or equal to at least 38% with the nucleotide sequence designated RXA0142C (SEQ ID NO: 7), a nucleotide sequence representing a level of identity that is greater or at least equal to 43% relative to the nucleotide sequence designated RXA00104 (SEQ ID NO: 5), and a nucleotide sequence that exhibits a level of identity that is greater than 45% or so less equal to 45%, relative to the nucleotide sequence designated RXA02173 (SEQ ID NO: .25). A person with ordinary knowledge in the art will be able to calculate the lower percent identity limit for any given sequence of the invention by examining the percentage identity scores calculated by GAP presented in Table 4 for each of the three superior results for the given sequence., and subtracting from 100% the percentage identity calculated by higher GAP. A person with oridinary concordances in the matter will recognize that the sequences of nucleic acids and amino acids that have percentages greater than the lower limits calculated in this way (a level of identity of at least 50%, 51%, 52%, 53% , 54%, 55%, 56%, 57%, 58%, 59% or 60%, preferably at least 61%, 62%, 63% 64%, 65%, 66%, 67%, 68% , 69% or 70%, with greater preference of at least approximately 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89% or 90% or 91%, 92%, 93%, 94%, and even greater preference, 95%, 96%, 97%, 98%, 99% or more) are also within the scope of the present invention. In addition to the nucleotide sequences of MCT from C. glutamicum presented in the Sequence List as SEQ ID NOs of an odd number, a person with ordinary knowledge in the art will observe that polymorphisms of DNA sequences that cause changes in the amino acid sequences of MCT proteins can exist within a population (for example, the population of C. glutamicum). Such genetic polymorphism in the MCT gene can exist between individuals within a population due to natural variation. As used herein, the terms "gene" and "recombinant gene" refer to nucleic acid molecules that comprise an open reading frame that encodes a MCT protein, preferably a MCT protein of C. glutamicum. Such natural variations can typically result in a variation of 1-5% in the nucleotide sequence of the MCT ce gene. Each and every one of these variations and polymorphisms resulting from amino acids in MCT that are the result of natural variation and that do not alter the functional activity of MCT proteins are contemplated within the framework of the present invention. Nucleic acid molecules corresponding to natural variants and non-C. glutamicum homologs of the C. glutamicum MCT DNA of the invention can be isolated on the basis of their homology to the C. glutamicum MCT nucleic acid disclosed herein using the DNA of C. glutamicum or a part thereof, as a hybridization shadow in accordance with standard hybridization techniques under stringent hybridization conditions. Accordingly, in another embodiment, an isolated nucleic acid molecule of the invention has a length of at least 15 nucleotides and hybridizes under stringent conditions to the nucleic acid molecule comprising a nucleotide sequence of a SEQ ID NO: e Odd number of the Sequence List. In other embodiments, the nucleic acid is at least 30, 50, 100, 250 or more nucleotides in length. As used herein the expression "hybridizes under stringent conditions" is intended to describe hybridization and washing conditions under which sequences having a homology of at least 6C% between them typically remain hybridized to each other. Preferably, the conditions are such that sequences exhibiting at least about 65% homology, more preferably at least about 70% homology, and preferably greater sequences exhibiting at least 75% homology between them remain typically hybridized between them. Such stringent conditions are known to those of ordinary skill in the art and can be found in Current Protocols in Molecular Biology, John Wiley & amp; amp;; Sons. N.Y. (1989), 6.3.1-6.3.6. A preferred non-limiting example of stringent hybridization conditions is hybridization in 6X sodium chloride / sodium citrate (SSC) at a temperature of about 45 ° C followed by one or more washes in 0.2 X SSC, 0.1% SDS at a temperature Preferably, an isolated nucleic acid molecule of the invention that hybridizes under stringent conditions to a nucleotide sequence of the present invention corresponds to a naturally occurring nucleic acid molecule. As used herein, a naturally occurring nucleic acid molecule refers to an RNA or DNA molecule having a nucleotide sequence that occurs in nature (eg, encodes a natural protein). In one embodiment, the nucleic acid encodes a natural MCT protein of C. glutamicum.

In addition to naturally occurring variants of the MCT sequence that may exist in the population, a person with ordinary knowledge in the art can observe that changes can be introduced by mutation in a nucleotide sequence of the invention, thereby causing changes in the amino acid sequence of the MCT protein encoded, without altering the functional capacity of the MCT protein. For example, nucleotide substitutions that cause amino acid substitutions in amino acid residues - "non-essential" - can be made in a nucleotide sequence of the invention. A non-essential amino acid residue is a residue that can be altered from a wild-type sequence of one of the MCT proteins (eg, a SEQ ID NO: of pair number from the Sequence List) without altering the activity of said MCT protein, while an "essential" amino acid residue is required for MCT protein activity. Other amino acid residues (however, for example those that are not conserved or only semi-conserved in the domain having an MCT activity) may not be essential for activity and therefore probably lend themselves to alteration without altering the activity of MCT. Accordingly, another aspect relates to nucleic acid molecules that encode MCT proteins that contain changes in amino acid residues that are not essential for MCT activity. Such MCT proteins differ in amino acid sequences from a sequence of a SEQ ID NO: of even number from the Sequence List and yet retain at least one of the MCT activities described herein. In one embodiment, the isolated nucleic acid molecule comprises a nucleotide sequence encoding a protein, wherein the protein comprises an amino acid sequence having a homology of at least about 50% with an amino acid sequence of the invention and can participate in the metabolism of compounds that are necessary for the construction of cell membranes in C. glutamicum, or in the transport of molecules through these membranes, or have one or more of the activities presented in Table 1. Preferably , the protein encoded by the nucleic acid molecule has a homology of at least about 50-60% with the amino acid sequence of one of the SEQ ID numbers of even numbers of the Sequence List, more preferably a homology of at least about 60-70% with one of these sequences, with even greater preference a homology of at least about 70- 80%, 80-90%, 90-95% with one of these sequences, and most especially at least about 96%, 97%, 98%, or 99% homology with one of the amino acid sequences of the invention. To determine the percentage of homology of two amino acid sequences (for example, one of the amino acid sequences of the invention and a mutant form thereof) or of two nucleic acids, the sequences are aligned for optimal comparison purposes (can be enter spaces in the sequence of a protein or nucleic acid for optimal alignment with the other nucleic acid protein). The amino acid residues or nucleotides at corresponding amino acid positions or corresponding nucleotide positions are then compared. When a position in a sequence (for example one of the amino acid sequences of the invention) is occupied by the same amino acid or nucleotide residue as the corresponding position in the other sequence (for example a mutant form of the amino acid sequence) then the molecules are homologous in this position (ie, in accordance with what is used here, the "homology" of the amino acid or nucleic acid is equivalent to the identity "of the amino acid or nucleic acid) the homology between the sequences depends on the number of identical positions shared by the sequences (ie, the percentage of homology = number of identical positions / total number of positions xlOO). An isolated nucleic acid molecule encoding an MCT protein homologous to a protein sequence of the invention (eg, a sequence of an SEQ ID NO: of even number from the Sequence List) can be created by introducing a or various substitutions, additions or deletions of nucleotides in a nucleotide sequence of the invention in such a way that one or more amino acid substitutions, additions or deletions are introduced into the encoded protein. Mutations can be introduced into one of the nucleotide sequences of the invention by standard techniques, such as for example site-directed mutagenesis and mutagenesis mediated by polymerase chain reaction. Preferably, conservative amino acid substitutions are made in one or more predicted nonessential amino acid residues. A conservative substitution of amino acids is a substitution in which the amino acid residue is replaced by an amino acid residue having a similar side chain. Families of amino acid residues that have similar side chains have been defined in the art. These families include amino acids with basic side chains (lysine, arginine, histidine) acid side chains (such as aspartic acid, glutamic acid) uncharged polar side chains (eg glycine, asparagine, glutamine, serine, threonine, tyrosine, cysteine), non-polar side chains (e.g. alanine, valine, leucine, isoleucine, proline, phenylalanine, methionine, tryptophan) side chains branched in beta (for example, threonine, valine, isoleucine), and aromatic side chains (for example tyrosine, phenylalanine, tryptophan, histidine). Thus, a non-essential amino acid residue predicted in MCT protein is preferably replaced by another amino acid residue of the same side chain family. Alternatively, in another embodiment, mutations can be introduced randomly over all or a portion of an MCT coding sequence, such as by saturation mutagenesis, and the resulting mutants can be screened to determine an MCT activity described herein for identify mutants that preserve MCT activity. After the mutagenesis of one of the nucleotide sequences of one of SEQ ID Nos. With odd number of the Sequence List, the encoded protein can be expressed recombinantly and the activity of the protein can be determined, using, for example, tests described here (see example 8 of the Examples). In addition to the nucleic acid molecules encoding MCT proteins described above, another aspect of the present invention relates to isolated nucleic acid molecules that are antisense. An "antisense" nucleic acid comprises a nucleotide sequence that is complementary to an antisense nucleic acid encoding a protein, for example, complementary to the coding strand of a double-stranded DNA molecule or complementary to an mRNA. Accordingly, an antisense nucleic acid can be linked by hydrogen to a sense nucleic acid. The antisense nucleic acid may be complementary to a complete MCT coding strand, or only a portion thereof. In one embodiment, an antisense nucleic acid molecule is antisense to a "coding region" of the coding strand of a nucleotide sequence encoding a MCT protein. The term "coding region" refers to the region of the nucleotide sequence comprising codons that are translated into amino acid residues, for example, the entire coding region of SEQ ID NO: 5 (RXA00104, comprises nucleotides 1 to 756) . In another embodiment, the antisense nucleic acid molecule is antisense to a "non-coding region" of the coding strand of a nucleotide sequence encoding MCT. The term "non-coding region" refers to the 5 'and 3' sequences that flank the coding region that are not translated into amino acids (ie, it is also known as 5 'and 3' untranslated regions). Given the coding strand sequences encoding MCT disclosed herein (eg, the sequences presented as SEQ ID NOs of even number in the Sequence Listing), antisense nucleic acids of the invention can be designed in accordance with the mating rules of bases of Watson and Crick. The antisense nucleic acid molecule may be complementary to the entire coding region of MCT mRNA, but more preferably it is an oligonucleotide that is antisense only relative to a portion of the coding or non-coding region of MCT mRNA. For example, the antisense oligonucleotide can be complementary to the region surrounding the translation start site of MCT mRNA. An antisense oligonucleotide can have, for example, about 5, 10, 15, 20, 25, 30, 35, 40, 45 or 50 nucleotides in length. An antisense nucleic acid of the invention can be constructed using chemical synthesis and enzymatic ligation reactions using procedures known in the art. For example, an antisense nucleic acid (for example an antisense oligonucleotide) can be chemically synthesized using naturally occurring nucleotides or modified nucleotides of various forms designed to increase the biological stability of the molecules or to increase the physical stability of the formed duplex between the antisense and sense nucleic acids, for example, phosphorothiate derivatives and nucleotides substituted by acridine can be used. Examples of modified nucleotides that can be used to generate the antisense nucleic acid include 5-fluorouracil, 5-bromouracil, 5-chlorouracil, 5-iodouracil, hypoxanthine, xanthine, 4-acetylcytokine, 5- (carboxyhydroxymethyl) uracil, 5-carboxylmethylaminomethyl- 2-thiouridine, 5-carboxymethyl inomethyluracil, dihydrouracil, beta-D-galactosylqueosine, inosine, N6-isopentenyladenine, 1-methylguanine, 1-methylinosine, 2,2-dimethylguanine, 2-methyladenine, 2-methylguanine, 3-methylcytocin, -methylcytocin, N6-adenine, 7-methylguanine, 5-methylaminomethyluracil, 5-methoxymethylmethyl-2-thiouracil, beta-D-mannosylqueosine, 5'-methoxycarbonylmethyluracil, 5-methoxyuracil, 2-methylthio-N6-isopentenyladenine, uracil-5 acid -oxyacetic (v), wibutoxosin, pseudouracil, queosin, 2-thiocytosine, 5-methyl-2-thiouracilc, 2-thiouracil, 4-thiuracil, 5-methyluracil, methyl ether of uracil-5-oxyacetic acid, uracil-5 acid -oxyacetic (v), 5-methyl-2-thiouracil, 3- (3-amino-3-N-2-carboxyprop) il) uracil, (acp3) w, and 2,6-diaminopurine. Alternatively, the sense nucleic acid can be produced biologically by employing an expression vector in which a nucleic acid has been subcloned in an antisense orientation (i.e., the RNA transcribed from the inserted nucleic acid will be of an antisense orientation). in relation to a target nucleic acid of interest, which is further described in the following subsection). The antisense nucleic acid molecules of the invention are typically administered to a cell or generated in situ in such a way that they hybridize either with cellular mRNA and / or genomic DNA encoding a MCT protein in order to inhibit in this way the expression of the protein, for example, by inhibition of transcription and / or translation. Hybridization can be carried out by conventional nucleotide complementarity in order to form a stable duplex, or, for example, in the case of an antisense nucleic acid molecule that binds with DNA duplexes, through specific interactions in the major split of the double helix. The antisense molecule can be modified such that it specifically binds to a receptor or an antigen expressed on a selected cell surface, for example, by linking the antisense nucleic acid molecule with a peptide or an antibody that it binds to a cell surface receptor or antigen. The antisense nucleic acid molecule can also be administered to cells using the vectors described herein. In order to achieve sufficient intracellular concentrations of the antisense molecules, vector constructs are referred in which the antisense nucleic acid molecule is placed under the control of a strong prokaryotic, viral or eukaryotic promoter. In another embodiment, the antisense nucleic acid molecule of the invention is an α-anomeric nucleic acid molecule. An α-anomeric nucleic acid molecule forms specific double-stranded hybrids with complementary RNA where, unlike the usual β units, the chains are parallel to each other (Gaultier et al (1987j Nucleic Acids Res. 15: 6625-6641). The antisense nucleic acid molecule can also comprise a 2'-o-methylribonucleotide (Inoue et al (1987), Nucleic Acid Res 15: 6131-6148) or a chimeric RNA-DNA analogue (Inoue et al (1987). ) FEBS Lett 215: 327-330) In another modality, an antisense nucleic acid of the invention is a ribozyme. Ribozymes are catalytic AF molecules with ribonuclease activity that can dissociate or single chain nucleic acid such as mRNA, with which they have a complementary region, such as ribozymes, for example hammerhead ribozymes (described in Haselhoff). and • Gerlach (1988) Nature 334: 585-591)) can be used to catalytically dissociate mRNA transcripts from MCT in order to thereby inhibit the translation of MCT mRNA A ribozyme having specificity for a nucleic acid encoding MCT can be designed based on the nucleotide sequence of MCT DNA disclosed herein (ie SEQ ID NO: 5 (RXA00104).) For example, an RNA derivative of Tetrahymena L-19 IVS can be constructed where the The nucleotide sequence of the active site is complementary to the nucleotide sequence to be dissociated in an mRNA encoding MCT See for example Cech et al US Patent Number 4,987,071 and Cech et al. U.S. Patent No. 5,116,742. Alternatively, MCT mRNA can be used to select a catalytic RNA having a specific ribonuclease activity from a set of RNA molecules. See, for example, Bartel, D and Szostak, J.W. (1993) Science 261: 1411-1418. Alternatively, MCT gene expression can be inhibited by focusing nucleotide sequences complementary to the regulatory region on a MCT nucleotide sequence (e.g., a promoter and / or MCT enhancers) to form triple helical structures that avoid the transcription of an MCT gene in target cells. See, in general terms, Helene, C. (1991) Anticancer Drug Des. 6 (6): 569-84; Helene C. Et al (1992) Ann N. Y. Acad Sci, 660: 27-36; and Maher, L. J. (992) Bioassays 14; 12): 807-15. B. Recombinant expression vectors and host cells Another aspect of the invention relates to vectors, preferably expression vectors containing a nucleic acid encoding a MCT protein (or a portion thereof). As used herein, the term "vector" refers to a nucleic acid molecule that can carry another nucleic acid to which it is attached. One type of vector is a "plasmid," which refers to a circular double-stranded DNA loop in which additional segments of DNA can be ligated. Another type of vector is a viral vector in which additional segments of DNA can be ligated into the viral genome. Certain vectors are capable of autonomous replication in a host cell into which they are introduced (eg, bacterial vectors having a bacterial origin of replication and episomal mammalian vectors). Other vectors (e.g., non-episomal mammalian vectors) are integrated into the genome of a host cell upon introduction into the host cell, and consequently, are replicated together with the host genome. In addition, certain vectors are capable of directing the expression of genes to which they are operatively linked. Such vectors are known herein as "expression vectors" in general, expression vectors useful in recombinant DNA techniques are often in the form of plasmids. In the present specification, the terms "plasmids" and "vector" can be used interchangeably since the plasmid is the most commonly used vector form. However, the invention is intended to include all other forms of expression vectors such as viral vectors (e.g., retroviruses, adenoviruses and adeno-associated viruses defective for replication), serve equivalent functions. The recombinant expression vectors of the invention comprise a nucleic acid of the invention in a form suitable for expression of the nucleic acid in a host cell, which means that the recombinant expression vectors include one or more regulatory sequences, selected based on the host cells to be used for expression, operatively linked to the nucleic acid sequence to be expressed. Within a recombinant expression vector, the term "operably linked" is intended to indicate that the nucleotide sequence of interest is linked to the regulatory sequence (s) in a manner that allows expression of the nucleotide sequence (for example, in a transcription system of an in vitro translation or in a host cell when the vector is introduced into the host cell). The term "regulatory sequence" is intended to include promoters, enhancers, and other expression control elements (e.g., polyadenylation signals). Such regulatory sequences are described, for example, in Goeddel; Gene Expression Technology; Methods in Enzymology 185, Academic Press, San Diego, CA (1990). Regulatory sequences include sequences that direct constitutive expression of a nucleotide sequence in many types of host cells and sequences that direct the expression of the nucleotide sequence only in certain host cells. Preferred regulatory sequences are, for example, promoters such as cos-, tac-, trp-, tet-, trp-tet-, lpp-, lac-, lpp-lac-, laclq-, T7-, T5-, T3- , gal-, trc-, ara-, SP6-, arny, SP02,? -PR- or? PL, which are preferably used in bacteria. Additional regulatory sequences, for example, are promoters from yeasts and fungi such as ADCl, MFa, AC, P-60, CYCl, GAPDH, TEF, rp28, ADH, promoters from plants such as CaKv / 355, SSU , OCS, lib4, usp, STLSl, B33, or ubiquitin or phaseolin promoters. It is also possible to use artificial promoters. A person with ordinary knowledge in the art will note that the design of the expression vector may depend on factors such as the choice of the host cell to transform, the level of protein expression desired. The expression vectors of the invention can be introduced into the host cells in order to thereby produce proteins or peptides, including proteins or fusion peptides, which are encoded by nucleic acids in accordance with what is described herein, eg proteins. of MCT, form mutants of MCT proteins, fusion proteins, etc. The recombinant expression vectors of the invention can be designed for expression of MCT proteins in prokaryotic or eukaryotic cells. For example MCT genes can be expressed in bacterial cells such as for example C. glutamicum, insect cells (using baculovirus expression vectors) yeast and other fungal cells (see Romans MA et al. (1992) "Foreign gene expression in yeast" : a review ", Yeast 8: 423-488; van den Hondel C.A.M.J.J. et al. (1991) "Heterologous gene expression in filamentous fungi" in: More Gene Manipulations in Fungi. J.W. Bennet & L.L. Lasure, eds., Pages 396-428: Academic Press: San Diego; and van den Hondel, C.A.M.J.J. & Punt, P.J. (1991) "Gene transfer systems and vector development for fungi, in: Applied Molecular Genetics of Fungi, Peberdy, JF et al., Eds. Pages 1-28, Cambridge University Press, Cambridge), algae and cells of multicellular plants ( see Schmidt, R. And Willmitzer, L. (1988) High efficiency Agrobacterium tumefaciens-transformation mediated by Arabidopsis thaliana leaf and cotyledon explants "Plant Cell Rep. 583-586), or mammalian cells. Suitable host cells are further discussed in Goeddel, Gene Expression Technology Methods in Enzymology 185, Academic Press, San Diego, CA (1990). Alternatively, the recombinant expression vector can be transcribed and translated in vitro, for example, using regulatory sequences of T7 promoter and T7 polymerase.

The expression of proteins in prokaryotes is most often effected with vectors containing constitutive or inducible promoters that direct the expression of either fusion proteins or non-fusion proteins. Fusion vectors add several amino acids to an encoded protein, usually to the amino terminus of the recombinant protein, but also at the C-terminus or fused to suitable regions in the proteins. Such fusion vectors typically have three purposes: 1) to increase the expression of recombinant protein; 2) increase the solubility of the recombinant protein; and 3) helping to purify the recombinant protein by its action as a ligand in affinity purification. Frequently, in fusion expression vectors, a proteolytic cleavage site is introduced at the junction of the fusion portion and the recombinant protein in order to allow the separation of the recombinant protein from the fusion portion of after the purification of the fusion protein. Enzymes of this type and their recognition sequences include the '< Xa, thrombin and enterokinase. Typical fusion expression vectors include pG? X (Pharmacia Biotech Inc., Smith D.B. and Johnson, K.S. (1983) Gene 67: 31-40); pMAL (New England Biolabs, Beverly, MA) and pRIT5 (Pharmacia, Piscataway, NJ) that fuse glutathione S-transferase (GST) maltose binding protein E, or protein A respectively, on the target recombinant protein. In one embodiment, the coding sequence of the MCT protein is cloned into a pGEX expression vector to create a vector encoding a fusion protein comprising, from the N-terminal to the C-terminus, GST-thrombin cleavage site - protein X. The fusion protein can be purified by affinity chromatography using glutathione-agarose resin the recombinant MCT protein not fused to GST can be recovered by dissociation of the fusion protein with thrombin. Examples of suitable E. coli non-fusible expression vectors include pTrc (Amann et al. (1988) Gene 69: 301-315! PLG338, pACYC184, pBR322, pUC18, pUC19, pKC30, pRep4, pee, pHSl , pHS2, pPLc236, pMBL24, pLG200, pUR290, pIN-1111-B1,? gtll, p3dCl, and pET lid (Studier et al., Gene Expression Technology and Methods in Enzymology 185, Academic Press, San Diego, California (1990) 60-89; and Pouwels et al., eds. (1985) Cloning Vectors. Elsevier: New York IBSN 0 444 904018). The expression of target gene from pTrc vector is based on the transcription of host RNA polymerase from a trp-lac hybrid fusion promoter. The expression of the target gene from the pET lid vector is based on transcription from the gn 10-lac fusion promoter of T7 mediated by a co-expressed viral RNA polymerase (T7 gnl). This viral polymerase is supplied per host strains BL2KDE3) or HMS174 (DE3) from a prophage? resident that contains a gnl gene of T7 under the transcriptional control of the lacUV5 promoter. For the transformation of other varieties of bacteria, appropriate vectors can be selected. For example, plasmids pIJIOl, pIJ364, pIJ702 and pIJ361 are useful for transforming Streptomyces while plasmids pUBllO, pC194 or pBD214 are suitable for transforming Bacillus species. Several plasmids useful in the transfer of genetic information in Corynebacterium include pHM1519, pBLl, pSA77 or pAJ667 (Pouwels et al., Eds. (1985) Cloning Vectors Elsevier: New York IBSN 0 444 904018). One strategy to optimize the expression of recombinant protein is to express the protein in a host bacterium with an affected capacity for the proteolytic dissociation of the recombinant protein (Gottesman, S., Gene Expression Technology Methods in Enzymology 185, Academic Press, San Diego, California (1990) 119-128). Another strategy is to alter the nucleic acid sequence of the nucleic acid to be inserted into an expression vector of t, as the individual codons for each amino acid are the codons used preferably in the bacterium selected for expression, as for example C. glutamicum (Wada et al. (1992) Nucleic Acids Res. 20: 2111-2118). Said alteration of nucleic acid sequences of the invention can be carried out by standard techniques of DNA synthesis. In another embodiment, the MCT protein expression vector is a yeast expression vector. Examples of vectors for expression of yeast S. cerivisae include pYepSecl (Baldari, et al., (1987) Embo J. 6: 229-234), 2 μ, pAG-1, Yep6, Yepl3, pEMBLYe23, pMFa (Kurjan and Herskowitz , (1982) Cell 30: 933-943), pJRY88 (Schuitz et al, (1937) Gene 54: 113-123) and pYES2 (Invitrogen Corporation, San Diego, CA). Vectors and methods for construction of appropriate vectors for use in other fungi, such as filamentous fungi, include the vectors and methods presented with details in: van den Hondel, C.A.M.J.J. & Punt, P.J. (1991) "Gene transfer systems and vector development for filamentous fungi, in: Applied Molecular Genetics of Fungi, JF Peberdy, et al., Eds., Pages 1-28, Cambridge University Press: Cambridge, and Pouwels et al., Eds (1985) Cloning Vectors, Elservier: New York (IBSN 0 444 904018) Alternatively, the MCT proteins of the invention can be expressed in insect cells using baculovirus expression vectors Baculovirus vectors available for expression of proteins in insect cells cultured (for example SF9 cells) include the pAc series (Smith et al (1983) Mol Cell Biol. 3: 2156-2165) and the pVL series (Lucklow and Summers (1989) Virology 170: 31-39). In another embodiment, the MCT proteins of the invention can be expressed in cells of unicellular plants (such as algae) or in cells of higher plants (for example, spermatophytes, such as harvest plants). In another embodiment, the MCT proteins of the invention can be expressed in cells of unicellular plants (such as algae) or in cells of higher plants (for example, spermatophytes, such as harvest plants). Examples of plant expression vectors include the vectors presented in detail in: Becker, D., Kemper, E., Schell, J. and Masterson, R. (1992) "New plant binary vectors with selectable markers located proximal to the left border ". Plant Mol. Biol. 20: 1195-119"; and Bevan, MW (1984)" Binary Agrcbacterium vectors for plant transformation ", Nuci Acid Res 12: 8711-8721, and includes pLGV23, pGHlac +,? BIN19, pAK2004, and pDH51 (Pouwels et al., Eds. (1985) Cloning Vectors, Elsevier: New York IBSN 0 444 904018) In another embodiment a nucleic acid of the present invention is expressed in mammalian cells using a mammalian expression vector. mammalian vectors include pCDM8 (Seed, B. (1987) Nature 329: 840) and pMT2PC (Kaufman et al. (1987) EMBO J. 6: 197-195) When used in mammalian cells, the control functions of the expression vector are often provided by viral regulatory elements, eg, commonly used promoters are polyoma derivatives, Adenovirus 2, cytomegalovirus and Simian Virus 40. For other expression systems suitable for both prokaryotic and eukaryotic cells, see Chapters 16 and 17 by Sambrook, J., Fritsh, EF, and Maniatis, T. Molecular Cloning: A Laboratory Manual. 2nd, ed., Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, -Cold Spring Harbor, NY, 1989. In another embodiment, the recombinant mammalian expression vector can direct expression of the nucleic acid of a particular type of cells (e.g., tissue-specific regulatory elements are used to express the nucleic acid). Specific regulatory elements for fabrics are known in the art. Examples or limitation of suitable tissue-specific promoters include the albumin promoter (specific for liver; Pinkert et al. (1987) Genes Dev. 1: 268-277), promoters! specific for lymphoid (Caiame and Eaton (1988) Adv. Immunol. 43: 235-275), in particular T cell promoters (Winoto and Baltimore (1989) EMBO J. 8: 729-733) and immunoglobulins (Banerji et al. (1983) Cell 33: 729-740; Queen and Baltimore (1983) Cell 33: 741-748), specific promoters for neurons (eg, the neurofilament promoter: Byrne and Ruddle (1989) PNAS 86: 5473-5477) , specific promoters for pancreas (Edlund et al (1985) Science 230: 912-916), and specific promoters for mammary gland (eg, whey promoter; US Patent No. 4,873,316 and European Application Publication No. 264,166 ). Developmentally regulated promoters are also included, for example, murine hox promoters (Kessel and Gruss (1990) Science 249: 374-379) and the ac-fetoprotein promoter (Campes and Tilghman (1989) Genes Dev. 3: 537 - 546). The invention further provides a recombinant expression vector comprising a DNA molecule of the invention cloned into the expression vector in an antisense orientation. That is, the DNA molecule is operatively linked to a regulatory sequence in such a way as to allow expression (by transcription of the DNA molecule) of an RNA molecule that is antisense to MCT mRNA. Regulatory sequences operably linked to a nucleic acid cloned in the antisense orientation can be selected which direct the continuous expression of the antisense RNA molecule in various cell types, for example viral promoters and / or enhancers, or regulatory sequences can be selected which direct tissue-specific or tissue-specific constitutive expression of antisense RNA. The antisense expression vector can be in the form of a recombinant plasmid, phagemid or attenuated virus er. where antisense nucleic acids are produced under the control of a high efficiency regulatory region whose activity can be determined by the type of cell into which the vector is introduced. For comments on the regulation of gene expression using antisense genes, see Weintraub, H. et al., Antisense RNA as a molecular tool for genetic analysis, Reviews - Trends go. Genetics, Vol. 1 (1) 1986. Another aspect of the invention relates to host cells into which a recombinant vector of the invention has been introduced. The terms "host cell" and "recumbent host cell" are used interchangeably herein. It is understood that said terms refer not only to the particular cell in question but to the progeny or to the potential progeny of said cell. Since certain modifications can occur in subsequent generations due either to mutations or to the influences of the environment, in fact said progeny may not be identical to the cell of origin, but it is still included within the scope of the term in accordance with what was used. here. A host cell can be any prokaryotic or eukaryotic cell. For example, an MCT protein can be expressed in bacterial cells such as C. glutamicum, insect cells, yeast or mammalian cells (eg, Chinese hamster ovary cells (CHO) or COS cells). Other suitable host cells are known to a person of ordinary skill in the art. Microorganisms related to Corynebacterium glutamicum that can conveniently be used as host cells for the protein and nucleic acid molecules of the invention are presented in Table 3. Vector DNA can be introduced into prokaryotic or eukaryotic cells through conventional transformation techniques or transfection. As always here the terms "transformation" and "transfection", "conjugation" and "transduction" are intended to refer to several known techniques for introducing nucleic acid per year (e.g., linear DNA or RNA (e.g., a linearized vector or a gene construct alone without a vector) or nucleic acid in the form of a vector (eg, a plasmid, phage, phasmid, phagemid, transposon, or other DNA) in a host cell, including coprecipitation with calcium chloride or phosphate of calcium, DEAE-dextran-mediated transfection, lipofection or electroporation Suitable methods for transforming or transfecting host cells can be found in Sambrook, et al. (Molecular Cloning: A Laboratory Manual, 2nd Edition, Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989), and other laboratory manuals. For a stable transfection of mammalian cells it is known that, according to the expression vector and according to the transfection technique used, only a small fraction of cells can integrate the foreign DNA into their genome. In order to identify and select these integrants, a gene encoding a selectable marker (e.g., resistance to antibiotics) is generally introduced into the host cells together with the gene of interest. Preferred selectable markers include markers that provide resistance to drugs, such as G418, hygromycin and methotrexate. A nucleic acid encoding a selectable marker can be introduced into a host cell in the same vector as nucleic acid encoding an MCT protein or it can be introduced into a separate vector. Stably transfected cells with the introduced nucleic acid can be identified by drug selection (for example, cells that have the selectable marker gene incorporated will survive, while the other cells will die). To create a homologous recombinant microorganism, a vector is prepared that contains at least a portion of an MCT gene into which a removal, addition or substitution has been introduced to alter in this way, for example, functionally upset the MCT gene . Preferably, this MCT gene is an MCT gene of Corynebacterium glutamicum, but can be a homolog of a related bacterium or even a mammalian, yeast or insect source. In a preferred embodiment, the vector is designed in such a way that homologous recombination must be performed, the endogenous MCT gene is functionally disrupted (ie, it no longer encodes a functional protein, it is also known as a "knock-out" vector) . Alternatively, the vector can be designed such that, upon homologous recombination, the endogenous MCT gene is mutated or otherwise altered but still encodes a functional protein (e.g., the upstream regulatory region can be altered with the object of altering in this way the expression of the endogenous MCT protein). In the homologous recombination vector the altered portion of the MCT gene is flanked at its 5 'and 3' ends by additional nucleic acid of the MCT gene to allow homologous recombination to occur between the exogenous MCT gene carried by the vector and a endogenous MCT gene in a microorganism. The additional flanking MCT nucleic acid has a sufficient length to effect a successful homologous recombination with the endogenous gene. Typically, several kilobases of flank DNA (both at the 5 'and 3' ends) are included in the vector (such as, for example, Thomas, KR, and Capecchi, MR (1987) Cell 51: 503 for a description of vectors of homologous recombination). The vector is introduced into a microorganism (eg, by electroporation) and cells in which the introduced MCT gene has recombined in a manner homologous to the endogenous MCT gene are selected, using known techniques. In another embodiment, recombinant microorganisms can be produced which contain selected systems that allow regulated expression of the introduced gene. For example, the inclusion of an MCT gene in a vector by placing it under the control of the lac operon allows the expression of the MCT gene only in the presence of IPTG. Such regulatory systems are well known in the art. In another embodiment, an endogenous MCT gene in the host cell is disrupted for example by homologous recombination or other genetic means known in the art! in such a way that the expression of your nc protein product occurs. In another embodiment, an endogenous MCT gene c well introduced into a host cell by one or more inversions, deletions or point mutations, but it continues to encode a functional MCT protein. , In another embodiment, one or more of the regulatory regions (such as, for example, a promoter, repressor or inducer) of an MCT gene in a microorganism has been altered (e.g., by removal, truncation, inversion or dot mutation) such that the expression of the MCT gene is modulated. A person of ordinary skill in the art will observe that host cells containing more than one of the described MCT gene and protein modifications can be readily produced using the methods of the invention and are included within the scope of the present invention. A host cell of the invention, such as for example a prokaryotic or eukaryotic cell in culture, can be used to produce (ie, express) an MCT protein. Accordingly, the invention further provides methods for the production of MCT protein using the host cells of the invention. In one embodiment, the metis comprises culturing the host cell of the invention (wherein a recombinant expression vector encodes a MCT protein has been introduced, or in whose genomes a gene encoding a MCT protein has been introduced. wild type or altered) in a suitable medium until the production of an MCT protein. In another embodiment, the method further comprises isolation of MCT proteins from the medium or host cell. C. Isolated MCT proteins Another aspect of the invention relates to isolated MCT proteins, as well as biologically active portions thereof. An "isolated" or "purified" protein or a biologically active portion thereof is substantially free of cellular material when produced by recombinant DNA techniques, or chemical precursors or other chemicals when chemically synthesized. The term "substantially free of cellular material" includes preparations of MCT protein wherein the protein is separated from cellular components of the cells where it is naturally or recombinantly produced. In one embodiment the expression "substantially free of cellular material" includes preparations of MCT protein having less than about 30% (dry weight) of non-PTS protein (also known as a "contamination protein"), with higher preferably less than about 20% non-PTS protein, preferably even higher, less than about 10% non-PTS protein, and most especially less than about 5% non-PTS protein. When the MCT protein or biologically active portion thereof is produced in a recombinant manner, it is also preferred that it be substantially free of the culture medium, that is, that the culture medium represents less than about 20%, more preferably less than about 10%, and most especially less than about 5% of the volume of the protein preparation. The expression "substantially free of chemical precursors or other chemicals" includes preparations of MCT protein wherein the protein is separated from the chemical precursors and other chemicals involved in the synthesis of the protein. In one embodiment, the phrase "substantially free of chemical precursors or other chemicals" includes MCT protein preparations having less than about 30% (by dry weight) of chemical precursors or non-PTS chemicals, more preferably less than about 2C% of chemical precursors or non-PTS chemicals, preferably still less than about 10% non-PTS chemical or chemical precursors, and most especially less than about 5% non-PTS chemical and chemical precursors. In preferred embodiments, isolated proteins or biologically active portions thereof do not have contaminating proteins from the same organism from which the MCT protein is derived. Typically, such proteins are produced by recombinant expression i, for example, of a MCT protein of C. glutamicum in a microorganism, such as for example C. glutamicum. An isolated MCT protein or a portion thereof of the invention can participate in the metabolism of compounds necessary for the construction of cell membranes in C. glutamicum, or in the transport of molecules through these membranes, or it has a or several of the activities presented in Table 1. In preferred embodiments, the protein or portion thereof comprises an amino acid sequence that is sufficiently homologous with an amino acid sequence of the invention (eg, a sequence of a SEQ ID NO. : of even number of the Sequence List) in such a way that the protein or portion thereof maintains the capacity to participate in the metabolism of compounds that are necessary for the construction of cell membranes in C. glutamicum, or in transport of molecules through these membranes. The portion of the protein is preferably a biologically active portion as described herein. In another preferred embodiment, an MCT protein of the present invention has an amino acid sequence presented as a SEQ ID NO: of even number from the Sequence List. In another preferred embodiment, the MCT protein has an amino acid sequence that is encoded by a nucleotide sequence that hybridizes, e.g., hybridizes under stringent conditions, to a nucleotide sequence of the invention, eg, a sequence. of SEQ ID NO: odd number of the Sequence List). In. Another preferred embodiment, the MCT protein has an amino acid sequence that is encoded by a nucleotide sequence that is at least about 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57% 58%, 59%, or 60%, most preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69% or 70%, preferably greater at least approximately 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79% or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89% or 90%, or 91%, 92%, 93%, 94% and with very special preference at least approximately 95%, 96%, 97%, 98%, 99 % or more homologous with one of the nucleic acid sequences of the invention, or a portion thereof. Intermediate ranges and values of identity in relation to the values mentioned above (for example, an identity of 70-90% or an identity of 80-95%) are also included within the framework of the present invention. For example, ranges of identity values employing a combination of any of the aforementioned values as upper and / or lower limit are also included within the maree of the present invention. The preferred MCT proteins of the present invention also preferably possess at least one of the MCT activities described herein. For example, a preferred MCT protein of the present invention includes an amino acid sequence encoded by a nucleotide sequence that hybridizes, such as, for example, hybridizes under stringent conditions, to a nucleotide sequence of the invention, and that can participate in the transport of molecules containing high-energy carbon, such as glucose in C. glutamicum, and may also participate in the metabolism of compounds necessary for the construction of cell membranes in C. glutamicum, or in the transport of molecules through these membranes, or having one or more of the activities presented in Table 1. In other embodiments, the MCT protein is substantially homologous with an amino acid sequence of the invention (such as, for example, a sequence of S? Q ID NO: of even number of the Sequence List) and preserves the functional activity of the protein of one of the amino acid sequences of the invention and however differs in the amino acid sequences due to natural variation or mutagenesis, in accordance with what is written in details in subsection I above. Therefore, in another embodiment, the MCT protein is a protein comprising an amino acid sequence having a homology of at least about 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57 %, 58%, 59% or 60%, preferably a homology of at least approximately 61%, 62%, 63%, 64%, 65%, £ 5%, 67%, 68% 69% or 70%, more preferably a homology of at least about 71%, 72%, 73%, 74%, 75%, "6%, 77%, 78%, 79% or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 86%, 89% or 90% or 91%, 92%, 93%, 94%, and even more preferably a homology of at least about 95%, 96%, 97%, 98%, 99% or more in relation to a whole amino acid sequence of the invention and having at least one of the MCT activities described here Intermediate identity values and ranges in relation to to the values mentioned above (for example an identity of 70-90% or an identity of 80-95%) are also within the scope of the present invention, for example, ranges of identity values that employ the combination of any the values mentioned above as upper and / or lower limit are within the scope of the present invention In another embodiment, the invention relates to a protein of C. glutamicum full length which is its substantially homologous with a whole sequence of amino acids of the invention. Biologically active portions of a MCT protein include peptides comprising amino acid sequences derived from the amino acid sequence of an MCT protein, for example, an amino acid sequence of a S? Q ID NO: of even number from the Sequence List or the amino acid sequence of a protein homologous to the MCT protein, which include fewer amino acids than a full-length MCT protein or the full-length protein that is homologous to a MCT protein, and have at least an activity of a MCT protein. Typically, biologically active portions (peptides, for example, peptides having, for example, 5, 10, 15, 20, 30, 35, 36, 37, 38, 39, 40, 50, 100 or more amino acids in length) comprise a domain or motif with at least one activity of a MCT protein. In addition, other biologically active portions, wherein other regions of the protein are removed, can be prepared by recombinant techniques and can be evaluated in relation to one or more of the activities described herein. Preferably, the biologically active portions of a MCT protein include one or more selected domains / motifs or portions thereof that have the biological activity. The MCT proteins are preferably produced by recombinant DNA techniques. For example, a nucleic acid molecule encoding the protein is cloned into an expression vector (as described above) the expression vector is introduced into a host cell (as described above), and the MCT is expressed in the host cell. The MCT protein can then be isolated from the cells through an appropriate purification scheme using standard protein purification techniques. Alternatively to the recombinant expression, a MCT protein, polypeptide, or peptide can be chemically synthesized using standard peptide synthesis techniques. In addition, a native MCT protein can be isolated from cells (eg, endothelial cells), for example using an anti-PTS antibody, which can be produced by standard techniques using an MCT protein or fragment thereof. invention. The invention also offers chimeric or fusion MCT proteins. As used herein, a "chimeric" MCT protein or a "fusion protein" of MCT comprises an MCT polypeptide operably linked to a non-PTS polypeptide. An "MCT polypeptide" refers to a polypeptide having an amino acid sequence that corresponds to MCT, while a "non-PTS polypeptide" refers to a polypeptide having an amino acid sequence that corresponds to a protein that is not substantially homologous with the MCT protein, as for example, a protein that is different from the MCT protein and that is derived from the same organism or from a different organism. Within the fusion protein, the term "operably linked" is intended to indicate that the MCT polypeptide and the non-PTS polypeptide are fused in frame with each other. The non-PTS polypeptide may be fused to the N-terminal or C-terminus of the MCT polypeptide. For example, in one embodiment, the fusion protein is a GST-PTS fusion protein where the MCT sequences are fused to the C-terminus of the GST sequences. Such fusion proteins can facilitate the encoding of recombinant MCT proteins. In another embodiment, the fusion protein is an MCT protein that contains a heterologous signal sequence at its N-terminus. In certain host cells (e.g., mammalian host cells), the expression and / or secretion of an MCT protein they can be increased through the use of a heterologous signal sequence. Preferably, a MCT, chimeric or fusion protein of the invention is produced by standard recombinant DNA techniques. For example, DNA fragments encoding the different polypeptide sequences are ligated together in a frame in accordance with conventional techniques, such as, for example, by use of terminals with flat ends or stepped ends for ligation, digestion with restriction enzyme to provide terminals appropriate, filling of cohesive ends as appropriate, treatment with alkaline phosphates to avoid undesirable binding, as well as enzymatic ligation. In another embodiment, the fusion gene can be synthesized by conventional techniques including automated DNA synthesizers. Alternatively, amplification by chain reaction of Polymerase fragments of the gene can be carried out using anchor primers that provide complementary projections between two consecutive fragments of gene that can be subsequently fused and reamplified to generate a chimeric gene sequence (see, for example, Current Protocols in Molecular Biology, Ausubel et al., John Wiley &Sons: 1992). In addition, many expression vectors are commercially available which already encode a fusion portion, eg, a GST polypeptide). A nucleic acid encoding an MCT can be cloned into said expression vector such that the fusion portion is bound in frame with the MCT protein. Homologs of the MCT protein can be generated by mutagenesis, for example, discrete point or truncated mutation of the MCT protein. As described herein, the term "homologs" refers to a variant form of the MCT protein that acts as an agonist or antagonist of the activity of the MCT protein. An MCT protein agonist can conserve substantially the same biological activities of the MCT protein or a subset of said biological activities. An antagonist of the MCT protein can inhibit one or more of the activities of the naturally occurring MCT protein form, for example by competitive binding to a downstream or upstream member of the metabolic cascade of cell membrane components which includes the MCT protein, or by the binding of an MCT protein that mediates the transport of compounds through such membranes, thus preventing translocation. In an alternative embodiment, homologues of the MCT protein can be identified by screening combinatorial libraries of mutants, eg, truncation mutants, of the MCT protein for MCT protein agonist or antagonist activity. In one embodiment, a library composed of variants of MCT is generated by combinatorial mutagenesis at the nucleic acid level and is encoded by a library composed of genes. A library composed of variants of MCT can be produced, for example, by enzymatically linking a mixture of synthetic oligonucleotides into gene sequences in such a way that a degenerate set of potential MCT sequences can be expressed as individual polypeptides or, alternatively, as a set of longer fusion proteins (e.g., for phage display) that contain MCT sequence set therein. There are several methods that can be used to produce libraries of potential MCT homologs from a degenerate oligonucleotide sequence. A chemical synthesis of a degenerate gene sequence in an automatic DNA synthesizer can be performed and the synthetic gene is then ligated into an appropriate expression vector. The use of a degenerate set of genes allows the delivery, in a mixture of all the sequences encoding the desired gene of potential MCT sequences. Methods for synthesizing oligonucleotides are known in the art (See, for example, Narang, SA (1983) Tetrahedron 39: 3, Itakura et al (1984) Annu, Rev. Biochem 53: 323, Itakura et al (1984) Science 198: 1056, Ike et al. (1983) Nucleic Acid Res. 11: 477. In addition, fragment libraries of the MCT coding protein can be used to generate a varied population of MCT fragments for screening and subsequent selection of homologs of an MCT protein. a library of fragments of coding sequences can be generated by treating the double-stranded fragment by polymerase chain reaction of an MCT coding sequence with a nuclease under conditions in which a cut occurs only approximately once per molecule, denaturing the DNA double chain, renaturing the DNA to form double-stranded DNA which may include sense / antisense pairs of different cut products, remove single chain portions of the reformed duplexes by treatment with nuclease SI and ligand the resulting fragment library into an expression vector. Through this method an expression library encoding an N, C terminal and internal fragments of various sizes of the MCT protein can be derived. Several techniques are known to screen gene products from combinatorial libraries made by dot or truncation mutations, and to screen cDNA library for gene products having a selected property.

Such techniques are adaptable for rapid screening of gene libraries generated by the combinatorial mutagenesis of MCT homolog. The most widely used techniques that lend themselves to high throughput analysis, to screen large gene libraries, typically include cloning the gene library into replicable expression vectors, transforming appropriate cells with the resulting library of vectors, and the expression of the combinatorial genes under conditions in which the protection of a desired activity facilitates the isolation of the vector encoding the gene whose product was detected. Recursive assembly mutagenesis REM), a new technique that increases the frequency of functional mutants in libraries, can be used in combination with screening assays to identify MCT homologs (Arkin and Yourvan (1992) PNAS 89: 7811-7815; Delgrave; et al. (1993) Protein Engineering 6 (3): 327-331). In another embodiment, cell-based assays can be exploited to analyze a varied MCT library, using methods well known in the art. D. Uses and Methods of the Invention The nucleic acid molecules, proteins, protein homologs, fusion protein, primers, vectors and host cells described herein can be used in one or more of the following methods: identification of C. glutamicum and organisms related; mapping of genomes of related organisms such as C. glutamicum; identification and location of sequences of interest of C. glutamicum; evolution studies; determination of MCT protein regions that are required per function; modulation of a MCT protein activity; the modulation of the metabolism of one or several cellular membrane components; the modulation of transmembrane transport of one or several compounds; and modulating the cellular production of a desired compound, such as a fine chemical. The MCT nucleic acid molecules of the invention have various uses. First, they can be used to identify an organism such as Corynebacterium glutamicum or a closely related organism. Likewise, they can be used to identify the presence of C. glutamicum c or a closely related organism in a mixed population of microorganisms. The invention offers the nucleic acid sequences of several genes of C. glutamicum, by probing DNA genome extracted from a culture of a single or mixed population of microorganisms under stringent conditions with a probe spanning a region of gene C. glutamicum that It is unique to this organism, it can determine if this organism is present. Although Corynebacterium glutamicum itself is not pathogenic, it is related to pathogenic species such as Corynebacterium Diphtheriae. Corynebacterium diphtheriae is the causative agent of diphtheria, an acute, rapidly developing febrile infection that includes both local and systemic pathology. In this disease, a local lesion develops in the upper respiratory tract and involves a necrotic lesion of the epithelial cells; the bacilli secrete toxin which is disseminated throughout this lesion to susceptible tissues of the body. Degenerative changes caused by the inhibition of protein synthesis in these tissues, which include heart, muscle, peripheral nerves, adrenal, kidneys, liver and spleen, result in the systemic pathology of the disease. Diphtheria continues to have a high incidence in many parts of the world, including Africa, Asia, Eastern Europe and the Independent States of the Former Soviet Union. A current epidemic of diphtheria in these last two regions resulted in the death of at least 5,000 people defends 1990. In one embodiment, the invention offers a method to identify the presence or activity of Corynebacterium diphtheriae in a subject, this method includes detection of one or more nucleic acid sequences or amino acids of the invention (for example, the sequences presented as SEQ ID NOs, of odd number or even number, respectively, in the List of Sequences) in a subject, thereby detecting the presence or activity of Corynebacterium diphtheriae in the subject. C. glutamicum and C. diphtheriae are related bacteria, and many of the nucleic acid and protein molecules in C. glutamicum are homologous to nucleic acid and protein molecules of C. diphtheriae, and therefore can be used to detect C. diphtheriae in a subject. The nucleic acid and protein molecules of the invention can also serve as markers for specific regions of a genome. This is useful not only in the genome mapping, but also for functional studies of C. glutamicum proteins. For example, to identify the region of the genome to which a particular DNA binding protein of C. glutamicum binds, the genome of C. glutamicum can be digested, and the fragments incubated with the DNA binding protein. Those that bind with the protein are additionally probed with the nucleic acid molecules of the invention, preferably with readily detectable labels; the union of said nucleic acid molecules I with the genome fragment allows the localization of the fragment in the genome map of C. glutamicum and, when carried out many times with different enzymes, facilitates a rapid determination of the nucleic acid sequence to which the protein binds. Furthermore, the nucleic acid molecules of the present invention can be sufficiently homologous by the sequences of related species in such a way that these molecules can serve as markers for the construction of a geonetic map in related bacteria, such as for example Brevibacterium lactofermentum. The MCT nucleic acid molecules of the invention are also useful for structural and evolutionary protein studies. The metabolic and transport processes in which the molecules of the present invention participate are utilized by a wide variety of prokaryotic and eukaryotic cells; By comparing the sequences of the nucleic acid molecules of the present invention with the sequences encoding similar enzymes of other organisms, the evolutionary relationship of the organisms can be determined. Similarly, such a comparison allows the evaluation of the regions of the sequence that are conserved and the regions of the sequence that are not conserved, which can help determine the regions of the protein that are essential for the functioning of the enzyme. This type of determination is valuable for studies of enzyme manipulation and may offer an indication of what the protein can tolerate in terms of mutagenesis without loss of funtion. The manipulation of the MCT nucleic acid molecules of the invention can result in the production of MCT proteins having functional differences compared to the wild-type MCT proteins. These proteins can have an improved efficiency or activity, they can be present in more important numbers in the cell compared to the usual level, or they can have a decreased efficiency or activity. The invention offers methods for screening molecules that modulate the activity of a MCT protein, either by interaction with the protein itself or a substrate or partner of the MCT protein, or by modulating the transcription or translation of a molecule of MCT nucleic acid of the invention. In such methods, a microorganism expressing one or more MCT proteins of the invention is in contact with one or more test compounds, and the effect of each test compound on the activity or expression level of MCT protein is evaluated. . There are numerous mechanisms through which the alteration of a MCT protein of the present invention can directly affect the yield, production, and / or production efficiency of a fine chemical from a C. glutamiciim strain. incorporates said altered protein. | The recovery of fine chemical compounds from large-scale cultures of C. glutamicum is significantly improved if C. glutamicum secretes the desired compounds, since such compounds can be easily purified from the culture medium difference extracted from the mass of cells of C. glutamicum). By increasing the number or activity of transporter molecules that export fine chemicals from the cell, it may be possible to increase the amount of fine chemical produced that is present in the extracellular medium, thus allowing greater ease of harvesting and purification. Conversely, in order to efficiently overproduce one or more fine chemicals, increased amounts of cofactors, precursor molecules, and intermediates are required for the appropriate biosynthetic pathways. Accordingly, by increasing the number and / or activity of carrier proteins involved in the importation of nutrients such as carbon sources (ie, sugars), nitrogen sources (ie, amino acids, ammonium salts), phosphate, and sulfur, it may be possible to improve the production of a fine chemical, due to the removal of limitations in the supply of nutrients in the biosynthetic process. Furthermore, fatty acids and lipids are themselves desirable chemical substances, such that by optimizing the activity or by increasing the number of one or more MCT proteins of the invention involved in the biosynthesis of these compounds, or either by affecting the activity of one or more MCT proteins involved in the degradation of these compounds, it may be possible to increase the yield, production and / or production efficiency of fatty acid and lipid molecules from C. glutamicum.

The manipulation of one or more MCT genes of the invention can also result in MCT proteins having altered activities that have an indirect impact on the production of one or more desired fine chemicals from C. glutamicum. For example, normal biochemical processes of metabolism result in the production of several waste products (eg, hydrogen peroxide and other reactive oxygen species), which can actively interfere with the same metabolic processes (eg, el-peroxynitrite is known by nitriding tyrosine side chains, thereby inactivating certain enzymes that have tyrosine in the active site (Groves, JT (1999) Curr. Opin. Chem. Biol. 3 (2): 226-235). While these waste products are typically excreted, the strains of C. glutamicum used for large-scale fermentative production are optimized for the overproduction of one or more fine chemicals, and therefore can produce more residual products than is typical for C. wild type glutamicum. By optimizing the activity of one or more MCT proteins of the invention involved in the export of residual molecules, it may be possible to improve the viability of the cell and maintain an efficient metabolic activity. Likewise, the presence of high intracellular levels of the desired fine chemical may in fact be toxic to the cell, such that by increasing the ability of the cell to secrete these compounds, the viability of the cell can be improved. In addition, the MCT proteins of the present invention can be manipulated in such a manner that the relative amounts of various molecules produced of lipids and fatty acid are altered. This can have a profound effect on the lipid composition of the cell membrane. Since each type of lipid has different physical properties, an alteration of the composition of the lipids of a membrane can significantly alter the fluidity of the membrane. Changes in the fluidity of the membrane can have an impact on the transport of molecules through the membrane, which, as explained previously, can modify the export of residual products or fine chemicals produced or the importation of necessary nutrients . Such changes in the fluidity of the membrane can also profoundly affect the integrity of the cell; Cells with relatively weaker membranes are more vulnerable in the large-scale fermentor environment to mechanical stresses that can damage or kill the cell. By manipulating MCT proteins involved in the production of fatty acids and lipids for the construction of membranes in such a way that the resulting membrane has a better membrane composition for the environmental conditions found in the crops used to produce the chemicals thin, a greater proportion of the cells of C. glutamicum will survive and multiply. Larger numbers of C. glutamicum cells in a culture should result in higher yields, higher production, or higher production efficiency of the fine chemical from the crop. The aforementioned mutagenesis strategies for MCT proteins to result in increased yields of a fine chemical from C. glutamicum are not intended to be limited; Variations of these strategies will be readily apparent to a person with normal knowledge in the field. Using these strategies, and incorporating the mechanisms disclosed herein, the protein and acide nucleic molecules of the present invention were presented to generate C. glutamicum or strains of related bacteria that express MCT protein and nucleic acid molecules with mutations in such a way that the yield, production and / or production efficiency of a desired compound is improved. This desired compound can be any natural product of C. glutamicum, which includes the final products of biosynthetic pathways and intermediates of naturally occurring metabolic pathways, as well as molecules that do not occur naturally in the metabolism of C. glutamicum, but which are produced by a strain of C. glutamicum of the invention. This invention is further illustrated through the following examples that should not be considered as limiting. The contents of all references, patent applications, patents, published patent applications, tables and the list of sequences mentioned in this application are incorporated herein by reference. TABLE 1: GENES IN THE APPLICATION Amino Acid Contig Code. NT NT nucleic acid initial identification end SEQ ID NO: SEQ ID NO: 1 2 RXN03097 W0062 3 557 3 4 RXA02099 GR0063C 6198 6470 5 6 RXA00104 GR00014 15895 16650 Nucleic acid Function SEQ ID NO: 1 AMMONIUM TRANSPORT SYSTEM 3 TRANSPORTATION SYSTEM OF AMMONIUM 5 PROTEIN CYSQ, ammonium carrier protein Synthesis of polyketides Amino Acid Contig. NT NT nucleic acid initial identification end SEQ ID NO: SEQ ID NO: 7 8 RXA01420 GR00416 775 17 9 10 RXN02581 W0098 30482 28623 11 12 F RXA02581 GR00741 1 1527 13 14 RXA02582 GR00741 1890 6719 15 16 RXA01138 GR00318 1656 2072 17 18 RXA01980 GR00573 1470 838 19 20 RXN01007 W0021 2572 866 21 22 RXN00784 W0103 27531 28265 Nucleic acid Function SEQ ID NO: 7 4"-MICftROSILISOVALERI L-COA TRAN SFERASA (EC 2.-.-.-) 9 SINTASE POLYCENTRY 11 SYNTHASE POLYQUETTE 13 PROBABLE POLYQUETTE SYNTHASE CY338.20 15 ACTINORHODINPOLIQUETIDO DIMERASA (EC -.-.- ) 17 POLYQUÉTIDO CICLASA 19 FRNA 21 FRNE Synthesis of fatty acids and lipids Amino Acid Contig Code. NT NT nucleic acid initial identification end SEQ ID NO: SEQ ID NO: 23 24 RXA02335 GR00672 550 2322 25 26 RXA02173 GR00641 7473 8924 27 28 RXA01764 GR00500 2178 3110 9 30 RXN02487 W0007 6367 4664 31 32 F RXA02487 GR00718 4937 4650 33 34 F RXA02490 GR00720 817 5 35 36 RXA01467 GR00422 920 1210 37 38 RXA00796 GR00212 202 5 39 40 RXA01897 GR00544 617 1159 41 42 RXN02809 W0342 380 6 43 44 F RXA02809 GR00790 277 5 45 46 RXN00113 W0129 103 5724 47 48 F RXA00113 GR00017 2 3295 49 50 RXN03111 W0084 6040 5 51 52 F RXA00158 GR00024 2088 4 53 54 F RXA00572 GR00155 2 3832 55 56 RXA02582 GR00741 1890 6719 57 58 RXA02691 GR00754 15347 14541 59 60 RXA00880 GR00242 6213 80 $ 7 61 62 RXA01060 GR00296 9566 10489 63 64 RXN01722 W0036 2938 12Í4 65 66 F RXA01722 GR00488 5746 4022 67 68 RXA01644 GR00456 9854 85? 77 69 70 RXA02029 GR00618 356 1669 71 72 RXA01801 GR00509 3396, 2380 73 74 RXN02512 W0171 16147 15185 75 76 F RXA02512 GR00721 3303 4259 77 78 RXA00899 GR00245 1599 2864 79 80 RXN00819 W0054 18127 19455 81 82 F RXA00819 GR00221 18 1007 83 84 F RXA01766 GR00500 4081 4371 85 86 RXN01762 W0054 15318 13783 87 88 F RXA01762 GR00500 1272 10 89 90 RXA00681 GR00179 3405 2662 91 92 RXA00802 GR00214 3803 4516 93 94 RXA02133 GR00639 3 308 95 96 RXN0114 W0182 9118 10341 97 98 F RXA01114 GR00308 2 793 99 100 RXA01894 GR00542 1622 2476 101 102 RXA02599 GR00742 3179 3655 103 104 RXN02638 W0098 54531 53656 105 106 F RXA02638 GR00749 8 511 107 108 RXA00856 GR00232 720 1256 109 110 RXA02511 GR00721 '12621 3277 111 112 RXN02836 W0102 32818 33372 1 113 114 F RXA02836 GR00827 106 411 115 116 RXA02578 GR00740; 2438 3541 117 118 RXA02150 GR00639 and 18858 19658 119 120 RXA00607 GR00160 1869 2249 121 122 RXA02397 GR09698 1688 2683 123 124 RXN03110 W0083 16568 17929 125 126 F RXA00660 GR00171 1027 5 127 128 RXA00801 GR00214 3138 3770 129 130 RXA00821 GR00221 1469 2311 131 132 RXN02966 W0143 12056 13462 133 134 F RXA01833 GR00517 1666 260 135 136 RXA01853 GR00525 5561 5010 137 138 RXN02424 W01I6 10570 11169 139 140 F RXA02424 GR00706 808 428 141 142 RXN00419 W0112 1024 266 143 144 F RXA00419 GR00095 3 464 145 146 F RXA00421 GR00096 565 723 147 148 RXN02923 W0038 3301- 2564 149 150 RXN02922 W0321 11407 10328 151 152 RXN03065 W0C38 6237 6629 153 154 RXN03132 W0127 39053 39472 155 156 RXN03157 W0I38 1607 1170 157 158 RXN00934 W0171 15181 14099 159 160 RXN00792 W0321 10328 9132 161 162 RXN00931 W0171 13011 12166 163 164 F RXA00931 GR0C253 4959 4114 165 166 RXN01421 W0122 16024 15638 167 168 RXN02342 W0C78 3460 4266 169 170 RXN00563 W0038 1 2739 171 172 RXN02168 W0100 2894 81 173 174 RXN01090 W0155 6483 5686 175 176 RXN02062 W0222 3159 1990 177 178 RXN02148 W0300 16561 17703 179 180 RXN02595 W0098 11098 9935 181 182 RXS00148 W0167 9849 12059 183 184 RXS00149 W0167 7995 9842 185 186 RXS02106 W0123 22649 21594 187 188 RXS01746 W0185 934 1686 189 190 RXS01747 W0185 1826 2869 191 192 RXC01748 W0185 3001 3780 193 194 RXC00354 W0135 33604 32792 195 196 RXC01749 W0185 3953 5569 Nucleic acid Function SEQ ID NO: 23 BIOTIN CARBOXYLASE (EC 6.3.4 .14) 25 ACETYL-COENZYME TO CARBOXYLASE CARBOXYLTRANSFERASE BETA SUBUNITY (EC 6.4.1.2) 27 3-OXOACIL-tP ^ ACILE CARRIER OTEIN] REDUCTASE (E) C 1.1.1.100) i 29 FATTY ACID! OF LONG CHAIN-COA LIGASA (EC I 6.2.1.3) 31 FATTY ACID! OF LONG CHAIN-COA LIGASE (EC 6.2.1.3) 33 LONG CHAIN GREASE ACID-COA LIGASE (EC 6.2.1.3) 35 ACILE CARRIER PROTEIN 37 Acyl phosphodiesterase carrier protein 39 Acyl phosphodiesterase carrier protein 41 Acyl phosphodiesterase carrier protein 43 Acyl phosphodiesterase carrier protein 45 SYNASE FATTY ACID (EC 2.3.1.85) [INCLUDES: EC 2.3.1.38; EC 2.3.1.39; EC 2.3.1.41; 47 FATTY ACID SINATASE 49 FATTY ACID SYNTHASE (EC 2.3.1.85) [INCLUDES: EC 2.3.1.38; EC 2.3.1.39; EC 2.3.1.41; EC 1.1.1.100; EC 4.2.1.61; EC 1.3.1.10; EC 3.1.2.14] 51 SYNTHETIC FATTY ACID (EC 2.3.1.85) 53 SYNTHETIC FATTY ACID (EC 2.3.1.85) 55 PROBABLE SYNTHASE POLYQUETTE CY338.20 57 REGULATOR RESPONSE TO FATTY ACIL 59 LONG CHAIN FATTY ACID-COA LIGASE (EC 6. 2.1.3) 61 OM ^ GA-3 DESATURATED FATTY ACID (EC 1.14.99.-) 63 CHLORINE ACID MEDIA-COA LIGASA (EC i 6.? 1 .-) 65 CHLORINE ACID MEDIA-COA LIGASA (EC 6. 2.1.-) 67, CICLOPROPANO-ACILO GRASO-FOSFOLIPIDO SINTASA (EC 2.1.1.79) 69 CYCLOPROPANE-FATTY ACILE-FOSFOLIPID SYNTHASE (EC 2.1.1.79) 71 ENOIL-COA HYDRAHASE (EC 4.2.1.17) 73 LIPID TO BIOSYNTHESIS LAROILACILTRANSFERASA (EC 2.3.1.-) 75 LÍPIDO A BIOSÍNTESIS LAUROILACILTRANSFERASA (EC 2.3.1.-) 77 CARDIOLIPINSINTETASA (EC 2.7.8.-) 79 ACIL-COA DEHYDROGENASE (EC 1.3.99.-) 81 ACIL-COA DEHIDROGENASA ( EC 1.3.99.-) 83 ACIL-COA DEHYDROGENASE (EC 1.3.99.-) 85 LONG CHAIN-COA FATTY ACID LIGASA (EC 6. 2.1.3) 87 CHLORINE ACID LAR.GA-COA LIGASA (EC 6. 2.1.3) 89 3-OXOACIL- [ACILE CARRIER PROTEIN] REDUCTASE (EC 1.1.1.100) 91 '3-OXOACIL- [ACILE CARRIER PROTEIN] ! REDUCTASE (EC 1.1.1.100) 93j 3-OXOACIL- [ACILE CARRIER PROTEIN] REDUCTASE (EC 1.1.1.100) 95: QUETOACIL-COA TIOLASE (EC 2.3.1.16) 97 QUETOACIL-COA TIOLASE (EC 2.3.1.16) 99 CITIDILILTRANSF RASA PHOSPHATASE (EC 2.7.7.41) 101 FOSFATIDILGLICEROFOSFATASA 3 (EC 3.1.3.27) 103 l-ACIL-SN-GLICEROL-3-PHOSPHATALACTRANSFERASE (EC 2.3.1.51) 105 l-ACIL-SN-GLICEROL-3-PHOSPHATALACTRANSFERASE (EC 2.3.1.51) 107 CDP-DIACILGLYCEROL-GLICEROL-3-PHOSPHATE-3-PHOSPHATROYLTRANSFERASE (EC 2.7.8.5) 109 CDP-DIACILGLYCEROL-GLICEROL-3-PHOSPHATE-3-PHOSPHATRODYLTRANSFERASE (EC 2.7.8.5) 111 QUETOACILREDUCTASE HETN (EC 1.3.1.-) 113 QUETOACILREDUCTASE HETN (EC 1.3.1.-) 115 ACILTRANSFERASE PUTATIVA 117 - l-ACIL-SN-GLICEROL-3-PHOSPHATE ACILTRANSFERASE (EC 2.3.1.51) 119 POLY (3-HYDROXIALCANATE) POLYMERASE (EC 2.3.1.-) 121 POLY-BETA-HYDROXYBUTYRATE POLYMERASE (EC 2.3.1. -) 123 HIDROXIACILGLUTATIONA HIDROLASA (EC 3.1.2.6) ! 125 HIDROXIACILGLUTATIONA HIDROLASA (EC 3.1.2.6) 127 HIDROXIACILGLUTATIONA HIDROLASE (EC 3.1.2.6) 129 HIDROXIACILGLUTATIONA HIDROLASE (EC 3.1.2.6) 131 HIDROXIACILGLUTATIONA HIDROLASE (EC 3.1.2.6) 133 HIDROXIACILGLUTATIONA HIDROLASE (EC 3.1.2.6) 135 HIDROXIACILGLUTATIONA HIDROLASE (EC 3.1.2.6) 137 HIDROXIACILGLUTATIONA HIDROLASE ( EC 3.1.2.6) 139 HYDROXYCILGLUTATIONA HYDROLASE (EC 3.1.2.6) 141 ACETOACETIL-COA REDUCTASE (EC 1.1.1.36) 143 ACETOACETIL-COA REDUCTASE (EC 1.1.1.36) 145 ACETOACETIL-COA REDUCTASE (EC 1.1.1.36) 147 ACETOACETIL- COA REDUCTASE (EC 1.1.1.36) 149 ACIL-COA DEHYDROGENASE, SPECIFIC FOR SHORT CHAIN EC (1.3.99.2) 151 HOLO- [ACILE CARRIER PROTEIN] SYNTHASE (EC 2. 7.8.7) 153 POLY-BETA-HYDROXYBUTYRATE POLYMERASE EC (2.3.1.-) 155 PROTEIN OF BIOSYNTHESIS OF NUCLEUS OF LIPOPOLISACÁRIDO KDTB 157 (AE000805) protein related to LPS biosynthesis RfbU [Methanobacterium thermoautotrophicum] 159 ACIL-COA DEHYDROGENASE, SPECIFIC TO SHORT CHAIN (EC 1.3.99.2) 161 ACIL-COA THIOESTERASE II (EC 3.1.2.-) 163 thioesterase II 165 ACILTRANSFERASE (EC 2.3.1.-) 167 BIOTIN- [ACETYL-COA-CARBOXYLASE] SYNTHETASE (EC 6. 3.4.15) 169 SYNTHETIC FATTY ACID (EC 2.3.1.85) [INCLUDES: EC 2. 3.1.38; EC 2.3.1.39; EC 2.3.1.41; EC 1. 1.1.100; EC 4.2.1.61; EC 1.3.1.10; EC 3.1.2.14] 171 SYNTHETIC FATTY ACID (EC 2.3.1.85) [INCLUDES: EC 2.3.1.38; EC 2.3.1.39; EC 2.3.1.41; EC 1.1.1.100; EC 4.2.1.61; EC 1.3.1.10; EC 3.1.2.14] 173 QUETOACILREDUCTASE HETN (EC 1.3.1.-) 175 Lipopolysaccharide N-acetylglucosaminyltransferase 177 Lipopolysaccharide N-acetylglucosaminyltransferase 179 Lipopolysaccharide N-acetylglucosaminyltransferase 181 METHYLMALONYL-COA MUTASE, ALPHA SUBUNITY (EC 5.4.99.2) 183 METHYLMALONYL-COA MUTASE , BETA SUBUNITY (EC 5,4.99.2) 185 LIPO-PROTEIN LIGASE A (EC 6.-.-.-) 187 LIPO-PROTEIN LIGASE B (? C 6.-.-.-) 189 SYNTHEASE OF LIPOIC ACID 191 protein involved in lipid metabolism 193 Cytosolic protein involved in lipid metabolism 195 Protein that covers the membrane involved in lipid metabolism Degradation of fatty acids Amino Acid Contig Code. NT NT nucleic acid initial identification end SEQ ID NO: SEQ ID NO: 197 198 RXA02268 GR00655 2182 3081 199 200 RXA02269 GR00655 3094 4065 201 202 RXA01614 GR00449 8219 7197 203 204 RXA01983 GR00573 3559 3053 205 206 RXN02947 W0078 1319 6 207 208 F RXA02320 GR00667 593 6 209 210 F RXA02851 GR00851 524 6 211 212 RXN02321 W0078 3291 1663 213 214 F RXA02321 GR00667 1380 937 215 216 F RXA02343 GR00675 1403 1816 217 218 F RXA02850 GR00850 2 493 219 220 RXA02583 GR00741 6743 8290 221 222 RXA00870 GR00239 809 2320 223 224 RXA01260 GR00367 2381 1200 225 226 RXA01261 GR00367 2607 2437 1 227 228 RXA01136 GR00318 685 1116 | 229 230 RXN00559 W0103 7568 6552 231 232 F RXA00559 GR00149 218 6 1 233 234 RXA01580 GR00440 707 6 235 236 RXA02677 GR00754 3119 3877 237 238 RXS01166 W0117 18142 16838 Nucleic acid Function SEQ ID NO: 197 LIPASE (EC 3.1.1.3) 199 LIPASE (EC 3.1.1.3) 201 LISOFOSFOLIPASE L2 (EC 3.1.1.5) 203 LIPASE (EC 3.1.1.3) 205 PROPIONIL-COA CARBOXYLASE BETA CHAIN (EC 6.4 .1.3) 207 PROPIONIL-COA CARBOXYLASE BETA CHAIN (EC 6.4.1.3) 209 PROPIONIL-COA CARBOXYLASE BETA CHAIN (EC 6.4.1.3) 211 PROPIONIL-COA CARBOXYLASE BETA CHAIN (EC 6.4.1.3) 213 PROPIONIL-COA CARBOXYLASE BETA CHAIN ( EC 6.4.1.3) 215 PROPIONIL-COA CARBOXYLASE BETA CHAIN (EC 6.4.1.3) 217 PROPIONIL-COA CARBOXYLASE BETA CHAIN (EC 6.4.1.3) 219 PROPIONIL-COA CARBOXYLASE BETA CHAIN (EC 6.4.1.3) 221 METHYLMALONATE-SEMILADEHYDE DEHYDROGENASE ( ACILATION) (EC 1.2.1.27, 2-methyl-3-oxopropanoate: NAD + oxide-reductase (CoA-propanoylation) 223 COMPONENT OF LIPOAMIDE DEHYDROGENASE (E3) OF ALPHA COMPLEX ALPHA-QUETO OF BRANCHED CHAIN DEHYDROGENASE (EC 1.8.1.4) 225 COMPONENT OF LIPOAMIDE DEHYDROGENABA (E3) OF ACID COMPLEX ALPHA-QUETO OF BRANCHED CHAIN DEHYDROGENASE (EC 1.8.1.4) 2 27 ISOVALERIL-COA DEHYDROGENASE (EC 1.3.99.10) 229 PROTEIN VDLD 231 PROTEIN VDLD 233 Glycerophosphoryldiester phosphodiesterase 235 GLYCEROSPHORYL DIESELASE (EC 3.1.4.46) 237 EXTRACELULAR LIPASE PRECURSOR (EC 3.1.1.3) Biosynthesis of terpenoids Amino Acid Contig Code. NT NT nnuucclleeiiccoo aacciiddo initial identification end .EQ ID NO: SEQ ID 3: I 239 240 RXA00875 GR00241 2423 | 1857 I 241 242 RXA01292 GR00373 12C4 | 2388 243 244 RXA01293 GR00373 2370 2696 2 24455 2 24466 RXA02310 GR00665 1132 ¡2394 247 248 RXA02718 GR00758 18539 19585 249 250 RXA01067 GR00298, 1453 2181 251 252 RXA01269 GR00367 20334 19894 253 254 RXA01205 GR00346 3 533 2 25555 2 25566 RXA01576 GR00438 8053 8811 257 258 RXN02309 W0025 28493 29542 259 260 F RXA02309 GR00665 978 4 261 262 RXN00477 W0086 38905 37262 263 264 F RXA00477 GR00119 13187 11544 265 266 RXA00478 GR00119 14020 13190 267 268 RXA01291 GR00373 345 1277 269 270 RXA00480 GR00119 17444 16329 271 272 RXS01879 W0105 1505 573 273 274 RXS02023 W0160 3234 4001 275 276 RXS00948 W0107 4266 5384 277 278 RXS02228 W0068 1876 2778 279 280 RXC01971 W0105 4545 3715 281 282 RXC02697 W0017 31257 32783 283 284 RXN01946 W0228 2 1276 285 286 F RXA01946 GR00559 1849 575 287 288 RXN00164 W0232 1782 94 289 290 F RXA00164 GR00025 1782 94 1 291 292 RXN00243 W005¡7 28915 27899 293 294 F RXA00243 GROO03 930 4 295 296 RXA00259 GR00039 8469 6268 297 298 RXN00410 W0086 51988 51323 299 300 F RXA00410, GR00092 829 164 301 302 RXN00456 W0076 6780 8156 303 304 F RXA00456 GR00114 316 5 305 306 F RXA00459 GR00115 1231 245 307 308 RXN01604 W0137 8117 7470 309 310 F RXA01604 GR00448 2 607 311 312 RXN02547 W0057 27726 25588 313 314 F RXA02547 GR00726 22055 19932 315 316 RXN02571 W0101 12331 13359 317 318 F RXA02571 GR00736 1469 2497 319 320 RXN02074 W0318 12775 11153 321 322 F RXA02074 GR00628 5798 4176 323 324 RXA02095 GR00629 14071 15474 325 326 RXA02225 GR00652 3156 2275 327 328 RXA02253 GR00654 20480 21406 329 330 RXN01881 W0105 529 95 331 332 F RXA01881 GR00537 3092 3532 333 334 RXA00526 GR00136 1353 664 335 336 RXN00733 W0132 1647 2531 337 338 F RXA00733 GR00197 411 4 339 340 RXA0073 ^ GR00198 849 181 341 342 RXA00878! GR00242 3733 1871 343 344 RXN01191 W0169 10478 12067 345 346 F RXA01191 GR00341 1571 165 347 348 RXN01212 W0169 3284 4207 349 350 F RXA01212 GR00350 1 813 351 352 RXA02749 GR00764 4153 5028 353 354 RXA02224 GR00652 2271 475 355 356 RXN01602 W0229 1109 2638 357 358 RXN02515 W0087 962 1717 359 360 RXN00525 W0079 26304 27566 361 362 RXN02096 W0126 20444 22135 363 364 RXN00412 W0086 53923 52844 365 366 RXN00411 W0086 52844 52170 367 368 RXN02614 W0313 5964 5236 369 370 RXN02613 W0313 5223 4267 371 372 RXN00368 W0226 2300 726 373 374 F RXA00368 GR00076 1 579 375 376 F RXA00370 GR00077 6 803 377 378 RXN01285 W0215 1780 1055 379 380 RXN00523 W0194 1363 338 381 382 RXN01142 W0077 5805 6302 383 384 RXN01141 W0077 4644 5468 385 386 RXN01002 W0106 8858 8055 387 388 RXN01000 W0106 7252 6407 389 390 RXN01732 W0106 9944 8895 1 391 392! 1 RXN03080 W0045 1670 2449 393 394, RXN03081 W0045 2476 2934 395 396 1 RXN03082 W0045 3131 3451 Nucleic acid Function SEQ ID NO: / 239 ISOPENTENIL-DIFOSPHATE DELTA- • ISOMERASE (E 5.3.3 -2) 241 PHYTOENE DEHYDROGENASE (EC 1.3., -.-) 243 FITOENO DEHYDROGENASE (EC 1.3.-.-) 246 GERANILGERANILHIDROGENASA 247 GERANILGERANILPIROFOSFATOSINTANSA (EC 2.5.1.1) 249 undecaprenyl-diphosphatesynthases (EC 2.5.1.31) 251 UNDECAPRENIL-PHOSPHATOGALACTSEFOSFOTRANSFERASA (EC 2.5.1.31) 253 UNDECAPRENIL-PHOSPHATE ALPHA-N-ACETYLGLUCOSAMI-NILTRANSFERASE PUTATIVA (EC 2.4.1.-) 255 DOLICHIL- BETA-GLUCOSYLTRANSFERASE PHOSPHATE (EC 2.4.1.117) 257 OCTAPRENYL-DIFOSPHATE SYNTHASE (EC 2.5.1.-) 259 OCTAPRENYL-DIFOSPHATE SYNTHASE (EC 2.5.1.-) 261 PHYTOENE DEHYDROGENASE (EC 1.3.-.-) 263 PHYTOENE DEHYDROGENASE (EC 1.3.-.-) 265 FITOENO SINTASA (EC 2.5.1.-) 267 FITOENO SINTASA (EC 2.5.1.-) 269 FARNESIL DIFOSFATOSINTASA (EC 2.5.1.1) (EC 2. 5.1.10) 271 isopentenyl phosphate kinase (EC 2.7.4.-) 273 cytochrome P450, isopentenyltrans, ferridox 275 12-oxophitodioate reductase (EC 1.3.1.42) 277 TRNA DELTA (2) -ISOPENTENYL PYROPHOSPHATE TRANSFERASE (EC 2.5.1.8) 279 Metal-dependent hydrolase involved in terpenoid metabolism 281 Membrane protein involved in terpenoid metabolism 283 Hypothetical binding protein of ATP transporter of ABC 285 (AL021184) ATP binding protein ABC transporter [ Mycobacterium tuberculosis] 287 Hypothetical binding protein of ATP transporter ABC 289, P, G, R ATPase transporter subunits of ABC 291, P, G, R ATPase transporter subunits of ABC 293, P, G, R ATPase transporter subunits of ABC 295, P, G, R ATPase subunits of ABC transporters | I 297 TRANSPORT ATP TRANSPORT PROTEIN GLUTAMINE GLNQ, 299, P, G, R ATPase subunits of ABC transporters 301, P, G, R, ATPase transporter subunits of ABC 303, p, G, R ATPase subunits of ABC transporters 305, P, G, R ATPase transporter subunits of ABC 307, P, G, R ATPase subunits of ABC transporters 309, P, G, R ATPase transporter subunits of ABC 311, P, G, R ATPase transporter subunits of ABC 313, P, G , R ATPase ABC transporter subunits 315 TRANSPORT ATP UNION PROTEIN MALTOSA / MALTODEXTRIN MALK 317, P, G, R ATPase subunits of ABC transporters 319 TRANSPORT ATP UNION PROTEIN CYDD 321, P, G, R ATPase transporter subunits i of A £ C I 323, P, G, R ATPase transporter subunits of ABC 325, P,: G, R ATPase subunits of ABC transporters 327. , P, G, R ATPase subunits of ABC transporters 329 Hypothetical transport protein binding protein ABC ATP 331 ATPase components of ABC transporters with duplicated ATPase domains 333 Hypothetical binding protein ATP of ABC transporter 335 Hypothetical binding protein ATP of transporter of ABC 337 Hypothetical binding protein ATP of ABC transporter 339 Hypothetical binding protein ATP of ABC transporter 341 Hypothetical binding protein ATP of ABC transporter 343 Hypothetical binding protein ATP of ABC transporter 345 Hypothetical binding protein ATP of transporter of ABC 347 Hypothetical binding protein ATP of ABC transporter 349 Hypothetical binding protein ATP of ABC transporter 351 Hypothetical binding protein ATP of ABC transporter 353 Hypothetical binding protein ATP of ABC transporter 355 Hypothetical binding protein ATP of transporter of ABC 357 Hypothetic protein ABC transporter ATP binding protein 359 Hypothesic transporter permease protein ABC 361 Hypothetical protein transporter permease ABC 363 Hypothetical binding protein ATP amino acid transporter ABC 365 Hypothetical amino acid transporter protein permease ABC 367 ATP UNION UNION PROTEIN TRANSPORT OF TAURINE TAUB 369 PRECURSOR OF PERIPLASMIC PROTEIN OF TAURINE UNION! 371 ATP TRANSPORT UNION PROTEIN I SPERMIDINE / PUTRESCINE POTA j 373 SPERMIDINE TRANSPORTATION ATP TRANSPORTATION PROTEIN / POTATO PUTRESCIN 375 SPERMIDINE TRANSPORTATION ATP TRANSPORTATION PROTEIN / POTA PUTRESCIN 377 TRANSPORTATION UNION ATP TRANSPORTATION OF FERCAL ENTEROBACTIN FEPC 379 TRANSPORTATION PROTEIN IN FERROUS ENTEROBACTIN PROTEIN FEPG 381 NITRATE TRANSPORT ATP TRANSPORT PROTEIN NRTD 383 NITRATE TRANSPORT PROTEIN NRTA 385 ATP TRANSPORT UNION PROTEIN PHNC 387 PERMEASE PROTEIN PHOSPHONATE TRANSPORT SYSTEM PHNE 389 PERIPLASM PROTEIN PRECURSOR OF PHOSPHONATE UNION 39-1 TRANSPORT ATP UNION PROTEIN D? FETRIC ENTEROBACTINE FEPC 393 PRECURSOR OF PERIPLASMIC PROTEIN OF UNION D? FERROUS ENTEROBACTINE 395 PRECURSOR OF PERIPLASMIC PROTEIN OF UNION D? FERROUS ENTEROBACTIN Other transporters Amino Acid Contig Code. NT NT nucleic acid initial identification end SEQ ID NO: SEQ ID NO: 397 398 RXA02261 GR00654 30936 32291 399 400 RXA02020 GR00613 1015 5 401 402 RXA00281 GR00043 4721 5404 403 404 RXN00570 W0147 855 4 405 406 F RXA00570 GR00153 1 498 407 408 RXN00571 W0173 1298 42 409 410 F RXA00571 GR00154 2 1186 411 412 RXA00962 GR00268 2 667 413 414 RXA02811 GR00792 177 560 415 416 RXA02115 GR00635 2 1198 417 418 RXN00590 W0178 5043 6230 419 420 F RXA00590 GR00157 178 564 421 422 F RXA01538 GR00427 5040 5429 423 424 RXA01727 GR00489 1471 194 425 426 RXA00623 GR00163 6525 7862 427 428 RXA01584 GR00441 55 597 429 430 RXA00852 GR00231 3137 2448 431 432 RXA00690 GR00181 1213 68 433 434 RXA00827 GR00223 1319 567 435 436 RXA00851 GR00231 2448 1840 437 438 RXS03220 439 440 F RXA02762 GR00768 346 630 441 442 RXN00092 W0129 27509 26844 443 444 F RXA00092 GR00014 1 204 445 446 RXN03060 W0030 6227 5376 447 448 F RXA02618 GR00745 1914 2351 449 450 F RXA02900 GR10040 2979 2128 451 452 RXS03212 453 454 F RXA01591 GR00446 3 947 455 456 RXN00201 W0096 197 6 457 458 F RXA00201 GR00032 191 6 459 460 RXA01221 GR00354 2108 2833 461 462 RXA01222 GR00354 2844 3542 463 464 RXA01219 GR00354 151 1032 465 466 RXA01220 GR00354 1032 2108 467 468 RXA00091 GR00013 7762 8514 469 470 RXA00228 GR00032 29232 28642 471 472 RXA00346 GR00064 1054 1743 473 474 RXA00524 GR00135 779 1111 475 476 RXA01823 GR00516 591 1367 477 478 RXA02767 GR00770 1032 1814 479 480 RXA02792 GR00777 8581 7829 481 482 RXNC2929 W0090 36837 37874 483 484 F RXA01235 GR00358 1165 194 485 486 RXN02794 W0134 10625 9552 487 488 F RXA01419 GR00415 888 1151 489 490 F RXA02794 GR00777 10172 9552 491 492 RXN03079 W0045 644 1660 493 494 F RXA02865 GR10007 3832 2816 495 496 RXA00181 GR00028 3954 2383 497 498 RXAC0591 GR00158 229 1581 499 500 RXA01629 GR00453 3476 1965 501 502 RXA02030 GR00618 3072 1687 503 504 RXA00186 GR00028 12242 12988 505 506 RXA00187 GR00028 13097 13447 507 508 RXA01667 GR00464 703 1908 509 510 RXA02171 GR00641 6571 4919 511 512 RXA00902 GR00245 4643 5875 513 514 RXA00941 GR00257 1999 683 515 516 RXN00449 W0112 30992 32572 517 518 F RXA00449 GR001C9 2040 1036 519 520 F RXA01755 GR00498 352 5 521 522 RXA00269 GR00C41 1826 1038 523 524 RXA00369 GR00C ~ 6 586 1299 525 526 RXA02073 GR00628 4176 2647 527 528 RXA01399 GR004C9 1 1119 529 530 RXA01339 GR00239 8408 7164 531 532 RXA02527 GR00 ~ 25 5519 6847 533 534 RXN00298 W01"6 40228 42072 535 536 F RXA00298 GR00C48 4459 6303 537 538 RXA00596 GR001? 9 335 787 539 540 RXA02364 GR00686 841 215 541 542 RXN01411 W0051 26015 26779 543 544 RXN00960 W00 ~ 3 1139 105 545 546 RXN02447 W01C "14297 13203 547 548 RXN02395 W01 ~ 6 16747 14858 549 550 RXN02348 W00 ~ 5 6027 7910 551 552 RXN00297 WOGÍ 38630 39541 553 554 RXN03103 woo "": 845 1087 555 556 RXN02993 W0071 736 65 557 558 RXN00349 W0135 35187 36653 559 560 RXN03095 W0057 4056 4424 561 562 RXN03160 W0189 5150 5617 563 564 RXN02955 W0176 8666 9187 565 566 RXN03109 W0082 659 6 567 568 RXN02979 W0149 2150 2383 569 570 RXN02987 W0234 527 294 571 572 RXN03084 W0048 900 1817 573 574 RXN03183 W0372 1 417 575 576 RXN01139 W0077 2776 1823 577 578 RXN00378 W0223 8027 5418 579 580 RXN01338 W0032 2 1903 581 582 RXN00980 W0149 2635 4428 583 584 RXN00099 W0129 18376 17704 585 586 RXN02662 W0315 1461 1724 587 588 RXN02442 W0217 5970 6318 589 590 RXN02443 W0217 6818 7771 591 592 RXN00842 W0138 8636 7487 593 594 F RXA00842 GR00228 3208! 2009 595 596 RXN00832 W0180 3133 i 4182 597 598 RXN00466 W0086 63271 i 64266 599 600 RXN01936 W0127 40116 4138 ^ 601 602 RXN01995 W0182 2139 3476 603 604 RXN00661 W0142 9718 9029 Nucleic acid Function SEQ ID NO: 397 AMMONIUM TRANSPORT SYSTEM 399 AROMATIC AMINO ACID TRANSPORT PROTEIN AROP 401 ATP UNION PROTEIN BACITRACINE TRANSPORTATION BCRA 403 BENZOATE MEMBRANE TRANSPORT PROTEIN 405 BENZOATE MEMBRANE TRANSPORT PROTEIN 407 BENZOATE MEMBRANE TRANSPORT PROTEIN 409 BENZOATE MEMBRANE TRANSPORT PROTEIN 411 BENZOATE MEMBRANE TRANSPORT PROTEIN 413 BENZOATE MEMBRANE TRANSPORT PROTEIN 415 BENZOATE MEMBRANE TRANSPORT PROTEIN 417 TRANSPORT SYSTEM II CARRIER PROTEIN OF BRANCHED CHAIN AMINO ACIDS 419 TRANSPORTATION SYSTEM II CARRIER PROTEIN OF BRANCHED CHAIN AMINO ACIDS i 421 SYSTEM CARRIER PROTEIN II TRANSPORTATION I AND BRANCHED CHAIN AMINO ACIDS I 423 SYSTEM CARRIER PROTEIN, TRANSPORTATION OF BRANCHED CHAIN AMINO ACIDS 425 TRANSPORT PROTEIN OF C4-DICARBOXYLATE 427 CROMATO TRANSPORT PROTEIN 429 ATP UNION PROTEIN COBALT TRANSPORT CBIO 431 COBALT TRANSPORT PROTEIN CBIQ 433 COBALT TRANSPORT PROTEIN CBIQ 435 COBALT TRANSPORT PROTEIN CBIQ 437 D-XILOSA-PROTON SIMPORTER 439 D-XYLOSA PROTON SIMPORTER 441 ATP UNION PROTEIN GLUTAMINE TRANSPORT GLNQ 443 UNION PROTEIN ATP GLUTAMINE TRANSPORT GLNQ 445 ATP UNION PROTEIN GLUTAMINE TRANSPORT GLNQ 447 ATP UNION PROTEIN GLUTAMINE TRANSPORT GLNQ 449 ATP UNION PROTEIN GLUTAMINE TRANSPORT GLNQ 451 BETAINE GLYCINE TRANSPORTER BETP 453 BETAINE GLYCINE TRANSPORTER BETP 455 HIGH RIBOZA TRANSPORT PROTEIN RBSD | 457 HIGH-AFFINITY RIBOZA TRANSPORT PROTEIN RBSD i 459 ATP UNION PROTEIN AMINO ACID TRANSPORTATION OF HIGH-AFFINITY BRANCHED CHAIN BRAG 461 ATP TRANSPCRTE AMINO ACID UNION PROTEIN OF HIGH-AFFINITY BRANCHED CHAIN LIVF 463 HIGH-AFFINITY BRANCHED CHAIN AMINO ACID TRANSPORT PERMEASE PROTEIN LIVH 465 HIGH-AFFINITY BRANCHED CHAIN AMINO-ACID TRANSPORTATION PERMEASE PROTEIN LIVM 467 ATP UNION PROTEIN TRANSPORT OF DICIRATE OF IRON (III) FECE 469 PROTEIN OF UNION ATP TRANSPORT OF IRON DICITRATE (III) FECE 471 PROTEIN OF UNION ATP TRANSPORTATION OF DICITRATE OF IRON (III) FECE 473 PROTEIN OF UNION ATP TRANSPORTATION OF DICITRATE IRON (III) FECE 475 ATP UNION PROTEIN TRANSPORT OF IRON DICITRATE (III) FECE 477 ATP UNION PROTEIN TRANSPORT OF IRON DICITRATE (III) FECE 479 PROTEIN OF UNION ATP TRANSPORTATION OF DICITRATE OF IRON (III) FECE 481 PROTEIN OF PERMEASA OF TRANSPORT SYSTEM OF IRON DICITRATE (III) F? CD 483 PERMEASE PROTEIN OF TRANSPORT SYSTEM OF IRON DICITRATE (III) F? CD 485 PROTEIN OF PERMEASA OF TRANSPORT SYSTEM OF IRON DICITRATE (III) FECD 487 PROTEIN OF PERMEASA OF TRANSPORT SYSTEM OF IRON DICITRATE (III) F? CD 489 PERMEASE PROTEIN OF TRANSPORT SYSTEM OF IRON DICITRATE (III) F? CD 491 PROTEIN OF PERMEASA OF TRANSPORT SYSTEM OF IRON DICITRATE (III) F? CD 493 PERMEASE PROTEIN OF TRANSPORT SYSTEM OF IRON DICITRATE (III) F? CD 495 PROLINE TRANSPORT SYSTEM 497"PROLINE / BETAINE CONVEYOR" 499 PROLINE / BETAINE CONVEYOR 501 PROLINER / BETAI CONVEYOR TO 503 SHORT CHAIN ACID TRANSPORTER 505 SHORT CHAIN CARTRIDGE CONTAINER 507 PROTEIN CARRIER OF SIMPORT OF S0DIO / GLUTAMATE 509 SODIUM / PROLININE SIMPORTER t 511 P ^ DEPENDENT PHOSPHATE AND SODIUM PHOSPHATE TRANSPORT OTEIN 513 Sodium-dependent phosphate transport pyreine 515, Sodium-dicarboxylate symptote protein 517 Sodium-dicarboxylate symptote protein 519 Sodium syntax protein -dicarboxylate 521 ATP UNION PROTEIN TRANSPORT SPERMIDINE / PUTRESCINE POTA 523 ATP TRANSPORT PROTEIN TRANSPORT SPERMIDINA / PUTRESCINA POTA 525 ATP UNION PROTEIN TRANSPORT CYDC 527 ATP UNION PROTEIN TRANSPORT CYDD 529 SPECIFIC TRANSPORT PROTEIN FOR TIROSINE 531 TRANSLOCALIZER PRECURSOR 2- OXOGLUTARATE / MALATE 533 HIGHWAY TRANSPORT PROTEIN AFFINITY 535 Ectoin / proline / glycine betaine ectP 537 Carrier Potassium efflume system protein phaE 539 PERIPLASM PROTEIN PRECURSOR OF C4-DICARBOXYLATE UNION, PROTEIN D? TRANSPORTATION 541 SHIQUIMATO 543 TRANSPORTER PROTON / SODIUM-GLUTAMATE PROTEIN PROTEIN 545; SIMILAR GALACTOSA-PROTON 547 BETAIN GLYCINE TRANSPORTER BETP 549 SYSTEM POTASSIUM ABSORPTION PROTEIN KUP 551 Hypothetical nalonat transporter 553 GLUTAMATE UNION PROTEIN PRECURSOR 555 GLUTAMATE UNION PROTEIN 557 Hypothetical trehalose transport protein 559 PROTEIN HOMOLOGOUS CADMIUM EFFLUX SYSTEM ACCESSORY 561 CHROMIUM TRANSPORTING PROTEIN 5 563 DICARBOXYLATE TRANSPORTER 565 HEMINE TRANSPORTATION SYSTEM PERMEASE PROTEIN HMUU 567 PERIPLASMIC COMPONENT PRECURSOR OF MERCURY TRANSPORT PROTEIN 0 569 PERIPLASMIC COMPONENT OF MERCURY TRANSPORT PROTEIN 571 PRECURSOR OF PERIPLASMIC PROTEIN OF IRON DICIRATE (III) 573 UNION PROTEIN OF TREHAL03A / MALTOSA 5 575 PROTEIN OF CATIÓN EFFLUX SYSTEM CZCD ! 577 AT cation transport pipelines i I 579 CATIONES PACS TRANSPORTATION ATPASA (EC 3.6.1.-) 581 ATPASA B TYPE P TRANSPORTATION OF CATIONES 0 (EC 3.6.1.-) 583 TRANSPORT PROTEIN OF CYANX 585 CYANX TRANSPORT PROTEIN PEDEASE PROTEIN OF DIPEPTIDE TRANSPORT DPPC 587 membrane protein system transport 5 zinc 589 precursor of protein periplasmic binding zinc 591 PROTEIN CARRIER OF SI STEMA II TRANSPORT AMINOACIDO OF CHAIN RAMI FICADA 593 Permeases 595 ANTIPORTERO CALCIUM / PROTO? 597 Ferrichoid transporter proteins 599 PROTEÍDE DE EFFUJO DE MACRÓLIDOS 601 PROTEÍA A TRANSPORTATION PUTATIVA OF 3- (3-HYDROXYPENYL) PROPIONATE 603 PROTEIN OF PNUC Permeases Amino Acid Contigo Code. NT NT nucleic acid initial identification end SEQ ID NO: SEQ ID NO: 605 606 RXN02566 W0154 11823 13031 607 608 F RXA02561 GR00732 664 5 609 610 F RXA02566 GR00733 782 345 611 612 RXA00051 GR00008 5770 7173 613 614 RXA01172 GR00334 2687 4141 615 616 RXA02128 GR00637 2906 4600 617 618 RXA02634 GR00748 6045 7655 619 620 RXN02233 W0068 6856 3142 621 622 F RXA02233 GR00653 6856 8067 623 624 RXN02372 W0213 9311 11197 625 626 F RXA02372 GR00688 6 560 627 628 F RXA02377 GR00689 3336 4526 629 630 RXA02676 GR00754 2697 1309 631 632 RXN00432 W0112 14751 13267 633 634 F RXA00432 GR00100 1 891 635 636 F RXA00436 GR00101 45 569 637 638 RXA00847 GR00230 1829 381 639 640 RXN01382 W0119 8670 9761 641 642 F RXA01382 GR00405 1067 6 643 644 RXA02659 GR00753 2 313 645 646 RXN02933 W0176 30042 29233 647 648 RXN02991 W0072 618 4 649 650 RXN02992 W0072 342 621 651 652 RXN02996 W0069 1980 2648 653 654 RXN03126 W0112 9894 9001 655 656 RXN00443 W0112 21572 20769 657 658 RXN00444 W0112 20785 19949 659 660 RXN00193 W0371 1 594 661 662 RXN01298 W0116 2071 1142 Nucleic acid Func: ion SEQ ID NO: 605 NUCLEOSIDE permease NUPG 607 NUCLEOSIDE permease NUPG 609 NUCLEOSIDE permease NUPG 611 permease SPECIFIC FOR PROLINE PROY 613 SULFATE permease 615 SULFATE permease 617 SULFATE permease 619 URACIL permease 621 URACIL permease 623 xanthine permease 625 xanthine permease 627 XANTHINE PERMEASA 629 GLUCONATO PERMEASA 631 PERMEASE OF D-ALANINE LINKED TO NA (+) GLYCINE 633 PERMEASE OF D-ALANINE LINKED TO NA (+) GLYCINE 635 PERMEASE OF D-ALANINE LINKED TO NA (+) GLYCINE 637 APPA PRECURSOR OF OLIGOPEPTIDE UNION PROTEIN (permease) 639 APPA PRECURSOR OF UNION PROTEIN OLIGOPEPTIDE 641 APPA PRECURSOR OF OLIGOPEPTIDE BINDING PROTEIN (permease) 643 APPA PRECURSOR OF OLIGOPEPTIDE BINDING PROTEIN (permease) 645 DIPEPTITE TRANSPORT SYSTEM PERMEASE PROTEIN DPPC 647 GLUTAMINE TRANSPORT SYSTEM PERMEASE PROTEIN GLNP 649 PROTEIN GLUTAMINE TRANSPORT SYSTEM PERMEASE GLNP 651 TRANSFER PERMEASE PROTEIN FOR HIGH-AFFINITY BRANCHED CHAIN AMINO ACID LIVH 653 PERMEASE PROTEIN TRANSFER FROM THEORETICAL ACID TAGG 655 PERIPLASM PROTEIN FOR MOLYBDATE UNION PROTEIN 657 PROTEIN FROM PERMEASA OE TRANSPORTATION SYSTEM OF MOLYBDENUM MODB 659 PROTEIN OF PERMEASE OR? TRANSPORTATION SYSTEM OF STARCH DEGRADATION PRODUCTS POTENTIAL AMYD 661 PROTEIN OF PERMEASA OE TRANSPORT SYSTEM OF STARCH DEGRADATION PRODUCTS POTENTIAL AMYD Amino acid channel proteins Contig Code. NT NT nucleic acid initial identification end SEQ ID NO: SEQ ID NO: 663 664 RXA01737 GR00493 2913 3971 665 666 RXN02348 W0078 6027 Í 7910 667 668 RXA02426 SR00707 2165 633 669 670 RXN03164 W0277 1586 2455 671 672 RXN00024 W0127 64219 63275 Nucleic acid Function SEQ ID NO: 663 POTASSIUM CHANNEL PROTEIN 665 POTASSIUM ABSORPTION PROTEIN D? SYSTEM KUP 667 PROBABLE ANTIPORTER NA (+) / H (+) 669 BETA SUBUNITY OF POTASSIUM CHANNELS 671 BETA SUBUNITY OF POTASSIUM CHANNELS Synthesis of lipoprotein and lipopolysaccharides Amino Acid Contig Code. NT NT nucleic acid initial identification end SEQ ID NO: SEQ ID NO: 673 674 RXN01164 W0117 15894 14260 675 676 RXN01168 W0117 14224 13415 Nucleic acid Function SEQ ID NO: i 673 DOLICHOL-PHOSPHATE MANOSI TRANSFER / ilSA (EC i 2.4.1.83) / APOLIPOPROTEIN N-ACILTpANSFERASE i (EC 2.3.1.-) | 675 DOLICHOL-MANOSILTRANSFERA3A PHOSPHATE (EC 2.4.1.83) / APOLIPOPROTEIN N-ACILTRANSFERASE (EC 2.3.1.-) TABLE 2 - GENES EXCLUDED Genbank ™ Accession No.: A09073 Gene Name: ppg Gene Function: Fosfoenol pyruvate carboxylase Reference: Bachmann, B. et al. "DNA fragment coding for phosphoenolpiruvat corboxylase, recombinant DNA carrying said fragment, strains carrying the recombinant DNA and method for producing L-amino acids using said strains," Patent: EP 0358940-A 3 21/03/90 Access No. to Genbank ™: A45579, A45581, A45583, A45585, A45587 Gene Name: Gene Function: Threonine Dehydratase Reference: Moeckel, B. et al. "Production of L-isoleucine by means of recombinant micro-organisms with deregulated threonine dehydratase," Patent: WO 9519442-A 5 07/20/95 Genbank Accession No.: AB003132 Gene Name: murC; ftsQ; ftsZ Gene Function: - j Reference: Kobayashi, M. et al. "Clonihg, sequencing, and characterization of the ftsZ gene from cpryneform bacteria," Biochem. Biophys. Res. Commun., 236 (2): 383-388 (1997) Genbank Accession No.: AB0150123 Gene Name: murC; ftsQ Function of the Gene: i Reference: Wachi, M. et al. "A murC gene from Coryneform bacteria," Appl. Microbiol. Biotechnol., 51 (2): 223-228 (1999) Genbank Accession No.: AB018530 Gene Name: dtsR Gene Function: Reference: Kimura, E. et al. "Molecular cloning of a novel gene, dtsR, which rescues the detergent sensitivity of a mutant derived from Brevibacterium lactofermentum," Biosci.

Biotechnol. Biochem., 60 (10): 1565-1570 (1996) Genbank Accession No.: AB018531 Gene Name: dtsRl; dtsR2 Gene Function: Reference: Genbank Accession No.: AB020624 Gene Name: murl Gene Function: D-glutamate racemase Reference: Genbank Accession No.: AB023377 Gene Name: tkt j I Gene Function : transquetolasai I Reference: - j Access to Genbank ™: AB024708 Name of the Gene: gltB; gltD Gen Function: Large and Small Glutamine Subunits 2-oxoglutarate aminotransferase Reference: Genbank Accession No.: AB025424 Gene Name: acn Gene Function: aconitase Reference: Genbank Accession No.: AB027714 Gene Name: rep Gene Function: Replication Protein Reference: Access No. to Genbank ™: AB027715 Name of Gen: rep; aad Gene Function: Replication protein; aminoglycoside adenyltransferase Reference: Genbank Accession No.: AF005242 Gene Name: argC Gene Function: N-acetylglutamate-5-semialdehyde dehydrogenase Reference: Genbanjk ™ Accession No.: AF005635 i Gene Name: glnA | i Gene Function: Glutamine Synthetase Reference: - Genbank Accession No.: AF030405 Gene Name: (hisF Gene Function: Cyclase Reference: Genbank Accession No.: AF030520 Gene Name: argG Gene Function : Argininosuccinate synthetase Reference: Genbank Accession No.: AF031518 Gene Name: argF Gene Function: Ornithine Carbamolyransferase Reference: Genbank Accession No.: AF036932 Gene Name: aroD Gene Function: 3-dehydroquinate dehydratase Reference : Genbank Accession No.: AF038548 Gene Name: pyc Gen Function: Pyruvate carboxylase Reference: Genbank ™ Accession No.: AF038651 Name of the Gpn: dciAE; apti: Gene function: Binding protein with Dipeptide, adenine phosphoribosyltransferase, GTP pyrophosphokinase Reference: \ Wehmeier, L. et al. "The role of the Corynebacterium glutamicum reí gene in (p) ppGpp metabolism, " Microbiology, 144: 1853-1862 (1998) Genbank Accession No.: AF041436 Gene Name: argR Gene Function: Arginine Repressor Reference: Genbank Accession No.: AF045998 Gene Name: impA Function of Gen: Inositol monophosphate phosphatase Reference: Genbank Accession No.: AF048764 Gene Name: argH Gene Function: Argininosuccinate lyase Reference: Genbank Accession No.: AF049897 Gene Name: argC; argj; argB; argD; argF; argR; argG; argH Gene Function: N-acetylglutamyl phosphate reductase; ornithine acetyltransferase, N-acetylglutamate kinase; acetyl cortinin transminase; ornithine carbamoyltransferase; arin jinina repressor; argininosuccinate synthase; argininosuccinate lyase Reference: Genbank Access No: AF050109 Gene Name: inhA Gene Function: Carrier protein Enoil-acyl reductase Reference: Genbank Accession No.: AF050166 Gene Name: hisG Gene Function: ATP phosphoribosyltransferase Reference: Genbank Accession No.: AF051846 Gene Name: hisA Gene Function: Phosphoribosylformimino-5-amino-l-phosphoribosyl-4-imidazolecarboxamide isomerase Reference: Genbank Accession No.: AF052652 Gene Name: metA Function of Gene: Homoserine O-acetyltransferase Reference: Park, S. et al. "Isolation and analysis of metA, a methionine biosynthetic gene encoding homoserine acetyltransferase in Corynebacterium glutamicum," Mol.

Cells., 8 (3): 286-294 (1998) Genbank Accession No.: AF053071 Gene Name: aroB Gene Function: Dehydroquinate synthetase Reference: Genbank Accession No.: AF060558 Gene Name: hisH Gene Function: Glutamine Amidotransferase Reference: Genbank Accession No.: AF086704 Gene Name: hisE Gene Function: Phosphoribosyl-ATP-pyrophosphohydrolase Reference: Genbank Accession No.: AF114233 Gene Name: aroA Gene Function : 5-enolpiruvilshiquimato 3-phosphate synthase Reference: Genbank Accession No.: AF116184 Gene Name: panD Gene Function: L-aspartate-alpha-decarboxylase precursor Reference: Dusch, N. et al. "Expression of the Corynebacterium glutamicum panD gene encoding L-aspartate-alpha-decarboxylase leads to pantothenate overproduction in Escherichia coli, "Appl. Environ Microbiol., 65 (4) 1530-1539 (1999) Genbank Accession No.: AF124518 Gene Name : aroE; aroE Gene Function: 3-dehydrokinase; shiquimato dehydrogenase Reference: Genbank Accession No.: AF124600 Gene Name: aroC; aroK; aroB; pepQ Gene Function: Coris ato synthase; shikimate kinase; 3-dehydroquinate synthase; putative cytoplasmic peptidase Reference: Access No. to Genbank ™: AF145897 Name of Gene: inhA Function of Gene: -Reference: Genbank ™ Accession No.: AF1458 8 Gene Name: inhA Gene Function: - Reference: Genbank Accession No.: AJ001436 Gene Name: ectP Gene Function: Transport of ectoine, glycine, betaine, proline Reference : Peter, H. et al. "Corynebacterium glutamicum is equipped with four secondary carriers for compatible solutes: Identification, sequencing, and characterization of the proline / ectoine uptake system, Prc ?, and the ectoine / proline / glycine betaine carrier, EctP, "J.

Bacteriol., 180 (22): 6005-6012 (1998) Genbank Accession No.: AJ004934 Gene Name: dapD Gene Function: Tetrahydrodipicolinate succinylase (incomplete1) Reference: Wehrmann, A. et al. "Different modes of diaminopimelate synthesis and their role in cell wall integrity: A study with Corynebacterium glutamicum," J.

Bacteriol., 180 (12): 3159-3165 (1998) Genbank Accession No.: AJ007732 Gene Name: ppc; secG; amt; ocd; soxA Gene Function: Phosphoenolpyruvate carboxyiase; ? high affinity ammonium absorption protein; putative ornithine-cyclodecarboxylase; sarcosine oxidase Reference: Genbank Accession No.: AJO10319 Gene Name: ftsY, glnB, glnD, srp; amtP Gene Function: Involved in cell division; PII protein; uridyliltransferase (uridylyl removal enzyme); signal recognition particle; low affinity ammonium absorption protein Reference: Jakoby, M. et al. "Nitrogen regulation in Corynebacterium glutamicum; Isolation of genes involved in biochemical characterization of corresponding proteins, "FEMS Microbiol., 173 (2): 303-310 (1999) Genbank Accession No.: AJ132968 Gene Name: cat Gene Function: Chloramphenicol Acetyltransferase Reference: Genbank Accession No.: AJ224946 Gene Name: mqo Gene Function: L-malate; quinone oxidoreductase Reference: Molenaar, D. et al. "Biochemical and genetic characterization of the membrane-associated malate dehydrogenase (acceptor) from Corynebacterium glutamicum," Eur. J. Biochem., 254 (2): 395-403 (1998) Genbank Accession No.: AJ238250 Gene Name: ndh Gene Function: NADH dehydrogenase Reference: Genbank Accession No.: AJ238703 Name of Gen: by Gene Function: Porin Reference: Lichtinger, T. et al. "Biochemical and biophysical characterization of the cell wall porin of Corynebacterium glutamicum: The channel is formed by a low molecular mass polypeptide, "Biochemistry, 37 (43): 15024-15032 (1998) Access No. to Genbank ™: D17429 Name of the Gene: - Function of the Gene: Element that can be transposed IS31831 Reference: Vertes et al. "Isolation and characterization of IS31831, a transposable element from Corynebacterium glutamicum, "Mol.Microbiol., 11 (4): 739-746 (1994)! Do not . Access to Genbank ™: D84102 | I Gene Name: odhA, Gene Function: 2-oxoglutarate dehydrogenase ¡ Reference: Usuda, Y. et al. "Molecular cloning of the Corynebacterium glutamicum (Brevibacterium lacto, fermentum AJ12036) or gene encoding a novel type of 2-oxoglutarate dehydrogenase," Microbiology, 142: 3347-3354 (1996) Genbank Accession No.: E01358 Gene Name: hdh; hk Gene Function: Homoserine dehydrogenase; homoserin kinase Reference: Katsumata, R. et al. "Production of L-thereonine and L-isoleucine," Patent: JP 1987232392-A 1 12/10/87 Genbank Accession No.: E01359 Gene Name: Gene Function: Upper current of the initial codon of the homoserin gene kinase Reference: Katsumata, R. et al. "Production of L-thereonine and L-isoleucine," Patent JP 1987232392-A 10/12/87 Genbank Accession No.: E01375 Gene Name: Gene Function: Tryptophan Operon Reference: Genbank Accession No. ™: E01376 I Gene Name: trpL; trpE I I Gene Function: Peptide leader; anthranilate synthase Reference: Matsui, K. et al. "Tryptophan operon, peptide and protein coded as, utilization of tryptophan operon gene expression and production of tryptophan," Patent: JP 1987244382-A 10/24/87, Access No. to Genbank ™: E01377 Gene Name: Gene Function: Promoter and operator regions of tryptophan operon Reference: Matsui, K. et al. "Tryptophan operon, peptide and protein coded therein, utilization of tryptophan operon gene expression and production of tryptophan," Patent: JP 1987244382-A 10/24/87 Genbank Accession No.: E03937 Gene Name: Gene Function: Biotin-synthase Reference: Hatakeyama, K. et al. "ONA fragment containing gene capable of coding biotin synthetase and its utilization, Patent: JP 1992278088-A 02/10/92 Access No. to Genbank ™: E04040 Gene Name: Gene Function: diamino pelargonic acid aminotransferaea Reference: Koha a, K. et al. "" Gene coding diaminopelargonic acid aminotransferase and desthiobictin synthetase and its utilization, "Patent: JP 1992330284-íj 1 11/18/92 Genbank Access No.: E04041! Gene Name: Gene Function: destiobiotinsintasa Reference: Kohama, K et al. "Cene coding diaminopelargonic acid aminotransferase and desthiobictin synthetase and its utilization," Patent: JP 1992330284-A 1 18/11/92 Genbank Accession No.: E04307 Gene Name: Gene Function: Flavum aspartase Reference: Kurusu, Y. et al. "Gene DNA coding aspartase and utilization thereof," Patent: JP 1993030977-A 02/09/93 Genbank Accession No.: E04376 Gene Name: Gene Function: isocitric acid lyase Reference: Katsumata, R. et al. "Gene manifestation controlling DNA," Patent: JP 1993056782-A 3 09/03/93 Access No. to Genbank ™: E04377 Gene Name: Gene Function: terminal fragment N of isoacítrice lyase acid Reference: Katsumata, R. et al. "Gene demonstrates Control controlling DNA, "Patent: JP 1993056782-A 3 09/03/93 Genbank Accession No.: E04484 Name of Gen: - | Function of the Gene: Prefenato jdeshidratasa Reference: Sotouchi, N., et al. "Production of L-phenylalanine by fermentation," Patent: JP 1993076352-A 2 03/30/93 Access to Genbank ™: E05108 Gene Name: Gene Function: Aspartoquinasa Reference: Fugono, N. et al. "Gene DNA coding Aspartokinase and its use," Patent: JP 1993184366-A 1 27/37/93 Genbank Accession No.: E05112 Gene Name: Gene Function: Dihydro-dipicorinate synthetase Reference: Hatakeyama, K. et to the. "Gene DNA coding dihydrodipicolinic acid synthetase and its use," Patent: JP 1993184371-A 1 27/07/93 Genbank Accession No.: E05776 Gene Name: Gene Function: diaminopimelic acid dehydrogenase Reference: Kobayashi, M. et al. "Gene DNA coding Diaminopimelic acid dehydrogenase and its use, "Patent: JP 1993284970-A 1 02/11/93 Access No. to Genbank ™: E05779 Gene Name: Gene Function: Treoninsynthase I Reference: Kohama, K. et al. "Gene coding DNA threonine synthase and Its u e,?" Patent JP 1993284972-A 1 02/11/93 No. Genbank Accession ™: E06110 name Gene: Gene Function: prephenate dehydratase Reference: Kikuchi, T. al, "Production of L-phenylalanine by fermentation method," Patent: JP 1993344381-A 1 27/12/93 Access No. to Genbank ™: E06111 Name of Gene: Function of the Gene: Prefenato dehydratasa with mutation Reference: Kikuchi, T. et al. "Production cf L-phenylalanine by fermentation method," Patent: JP 1993344381-A 1 27/12/93 Genbank Accession No.: E06146 Gene Name: Gene Function: acetohydroxy synthetase acid Reference: Inui, M. et al. "Gene capable of coding Acetohydroxy acid synthetase and its use, "Patent: JP 1993344893-A 1 27/12/93 Access No. to Genbank ™: E06825 Gene Name: Gene Function: Aspartoquinasa Reference: Sugimoto, M. et al. "Mutant aspartokinase gene," patent: JP 1994062866-A 1 08/03/94 Genbank Accession No.: E06826 Gene Name: Gene Function: Alpha subunit of mutated aspartokinase Sugimoto, M. et al. "Mutant aspartokinase gene," 1994062866-A 1 08/03/94 Genbank ™ Accession No.: E06827 Gene Name: Gene Function: Alpha Subunit of Aspartokinase Mutated Reference: Sugimoto, M. et al. "Mutant aspartokinase gene," Patent JP 1994062866-A 1 08/03/94 Genbank Accession No.: E07701 Gene Name: secY Gene Function: Reference: Honno, N. et al. "Gene DNA involved in integration of membrane protein to membrane," Patent: J? 1994169780-A 1 06/21/94 No. Access to Genbank ™: E08177 Gene Name: Gene Function: Aspartoquinasa Reference: Sato, Y. et a. "Genetic DNA capable of coding aspartokinase released from feedback inhibition and Its utilization," Patent JP 1994261"'66 -A 1 09/20/94 No. Genbank Accession ™: E081 ~ 78, E08179, E08180, E08181, E08182 Gene Name: Gene Function: Aspartokinase Release of Feedback Inhibition Reference: Sato, Y. et al. "Genetic DNA capable of coding I aspartokinase released from feedback inhibition and Its utilization, "Patent JP 1994261 ~ 66-A 1 20/09/94, Genbank Accession No. ™: E08232 Gene Name: Gene Function: acetohydroxy acid Isomeroreductasa Reference: Inui , M. et al. "Gene DNA coding acetohydroxy acid isomeroreductase", Patent: JP 1994277067-A 1 04/10/94 Access No. to Genbank ™: E08234 Gene Name: secE Gene Function: Reference: Asai, Y et al. "Gene DNA coding for translocation machinery of protein," Patent: JP 1994277073-A 1 04/10/94 Genbank Accession No.: E08643 Gene Name: Gene Function: FT aminotransferase promoter region and Destinobiotin synthetase Reference: Hatakeyama, K. et al. "DNA fragment having promoter function in coryneform bacterium," Patent: JP 1995031476-A 1 03/02/95 Access No. to Genbank ™: E08646 Gene Name: Gene Function: Biotinsintetase Reference: Hatakeyama, K. et al. "DNA fragment having promoter function in coryneform bacterium," Patent: JP 1995031476-A 1 03/02/95 Genbank Accession No.: E08649 Gene Name: Gene Function: Aspartase Reference: Kohama, K. et al. "DNA fragment having premoter function in coryneform bacterium," Patent: JP 1995031478-A 1 03/02/95 Genbank Accession No.: E08900 Gene Name: Gene Function: Dihydrodipicolinate reductase Reference: Madori, M. et al. "DNA fragment gene coding Dihydrodipicolinate acid container containing reductase and utilization thereof," Patent: JP 1995075578-A 1 20/03/95 No. Genbank Accession ™: E08901 Gene Name: Gene Function: diaminopimelic acid decarboxylase Reference: Madori, M. et al. "DNA fragment containing gene coding Diaminopimelic acid decarboxylase and utilization therof," Patent: JP 1995075579-A 1 03/20/95 Genbank Accession No.: E12594 Gene Name: Gene Function: Serine hydroxymethyltransferase Reference: Hatakeyama, K . et al. "Prcduction of L-trypophan," Patent: JP 1997028391-A 1 04/02/97 Genbank Accession No.: E12760, E12759,? 12758 Gene Name: Gene Function: Transposase Reference: Moriya, M. et to the. "Amplification of gene using artificial transposon," Patent: JP 1997070291-A 03/18/97 Access No. to Genbank ™: E12764 Gene Name: Gene Function: Arginyl-tRNA synthetase; diaminopimelic acid decarboxylase Reference: Moriya, M. et al. "Amplification of gene using artificial transposon," Patent: JP 1997070291-A 03/18/97 Genbank Accession No.: E12767 Gene Name: Gene Function: Dihydropicolinic acid synthetase Reference: Moriya, M. et al. "Amplification of gene using artificial transposon," Patent: JP 1997070291-A 03/18/97 Access No. to Genbank ™: E12770 Gene Name: Gene Function: Aspartoquinasa Reference: Moriya, M. et al. "Amplification of gene using artificial transposon," Patent: JP 1997070291-A 03/18/97 Access No. to Genbank ™: E12773 Gene Name: Gene Function: Dihydrodipicolinic acid reductase Reference: Moriya, M. et al. "Amplification of gene using artificial transposon," Patent: JP 1997070291-A 03/18/97 Access No. to Genbank ™: El3655 Gene Name: Gene Function: Glucose-6-phosphate dehydrogenase Reference: Katakeyama, K. et al. "Glucose-6-phosphate dehydrogenase and DNA capable of coding the same," Patent: JP 1997224661-A 1 02/09/97 Genbank Accession No.: L01508 Gene Name: IlvA Gene Function: Threonine Dehydratase Reference: Moeckel, B. et al. "Functional and structural analysis of the threonine dehydratase of Corynebacterium glutamicum," J. Bacteriol., 174: 8065-8072 (1992) Genbank Accession No.: L07603 Gene Name: EC 4.2.1.15 Gene Function: 3- deoxy-D-arabinoheptulosonate-7-phosphate synthase Reference: Chen, C. et al. "The cloning and nucleotide sequence of Corynebacterium glutamicum 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase gene," FEMS Microbiol. Lett., 107: 223-230 (1993) Access No. to Genbank ™: L09232 Gene Name: IlvB; ilvN; ilvC Gene Function: Large subunit of acetohydroxy acid synthase; Small subunit of acide acetohydroxy synthase; isomeroreductase of acetohydroxy acid Reference: Keilhauer, C. et al. "Isoleucine synthesis in Corynebacterium glutamicum: molecular analysis of the ilvB-ilvN-ilvC operon," J. Bacteriol., 175 (17): 5595-5603 (1993) Genbank Accession No.: L18874 Gene Name: MCTM, Function of the Gene: Phosphoenolpyruvate sugar phosphotransferase Reference: Fouet, A. et al. "Bacillus subtilis sucrose-specific enzyme II of the phosphotransferase system: expression in Escherichia coli and homology to enzymes II from enteric bacteria," PNAS USA, 34 (24): 8773-8777 (1987); Lee, J.K. et al. "Nucleotide sequence of the gene encoding the Corynebacterium glutamicum mannose enzyme II and analyzes of the deduced protein sequence," FEMS Microbiol. Lett., 119 (1-2): 137-145 (1994) Genbank Accession No.: L27123 Gene Name: aceB Gene Function: Malate synthase Reference: Lee, H-S. et al. "Molecular characterization of aceB, a gene encoding malate synthase in Corynebacterium glutamicum," J. Microbiol. Biotechnol., 4 (4): 256-263 (1994) Genbank Accession No.: L27126 Gene Name: -Gen Gene Function: Pyruvate kinase Reference: Jetten, M.S. et al. "Structural and functional analysis of pyruvate kinase from Corynebacterium glutamicum," Appl. Environ. Microbiol., 60 (7): 2501-2507 (1994) Genbank Accession No.: L28760 Gene Name: aceA Gene Function: Isocitrate lyase Reference: Genbank Accession No.: L35906 Gene Name: dtxr Function of the Gene: Diphtheria toxin repressor Reference: Oguiza, JA et al. "Molecular cloning DNA sequence analysis, and characterization of the Corynebacterium diphtheriae dtxR from Brevibacterium lactofermentum, "J. Bacteriol., 177 (2): 465-467 (1995) Genbank Accession No.: M13774 Gene Name: - Gene Function: prefenate dehydratase Reference: Follettie, MT et al. "Molecular cloning and nucleotide sequence of the Corynebacterium glutamicum pheA gene," J. Bacteriol., 167: 695-702 (1986) Genbank Accession No.: M16175 Gene Name: 5S rRNA Gene Function: - Reference : Park, YH et al. "Phylogenetic analysis of the coryneform bacterium by 56 rRNA sequences," J. Bacteriol., 169: 1801-1806 (1987) Genbank Accession No. "M: M16663 Gene Name: trpE Gene Function: Anthranilate Synthase, 5 'End Reference: Sano, K. et al." Structure and function of the trp operon control regions of Brevibacterium lactofermentum, to glutamic-acid-producing bacterium, "Gene, 52: 191-200 (1987) Genbank Accession No.: M16664 Gene Name: trpA Gene Function: Tryptophan synthase, 3 'end Reference: Sano, K. et al. "Structure and function of the trp operon control regions of Brevibacterium lactofermentum, to glutamic-acid-producing bacterium," Gene, 52: 191-200 (1987) Genbank Accession No.: M25819 Gene Name: Gene Function: Phosphoenolpyruvate carboxylase Reference: O'Regan, M. et al. "Cloning and Nucleotide Sequence of the Phosphoenolpyruvate carboxylase-coding of Corynebacterium glutamicum ATCC 13032," Gene, 77 (2) 237-251 (1989) Genbank Accession No.: M85106 Gene Name: Gene Function: Sequence of insertion of 23S rRNA gene Reference: Roller, C. et al. "Gram-positive bacteria with a high DNA G + C content are charecteri? Ed by a common insertion within their 23S rRNA genes," J. Gen. Microbiol., 138: 1167-1175 (1992) Access No. to Genbank ™ : M85107, M85108 Gene Name: Gene Function: 23S rRNA insertion sequence Reference: Roller, C. et al. "Gram-positive bacteria with a high DNA G + C content are characteristically by a common insertion within their 23S rRNA genes," J. Gen. Microbiol., 138: 1167-1175 (1992) Access No. to Genbank ™ : M89931 Gene Name: aecD; brnQ; yhbw Gene Function: Beta C-S lyase; branched-chain amino acid absorption vehicle; hypothetical yhbw protein Reference: Rossol, I. et al. "The Corynebacterium glutamicum aecD gene encodes to C-S lyase with alpha, beta-elimination activity that degrades aminoethylcysteine," J. Bacteriol., 174 (9): 2968-2977 (1992); Tauch, A. et al. "Isoleucine uptake in Corynebacterium glutamicum ATCC 13032 is directed by the gene product," Arch. Mirobiol., 169 (4): 303-312 (1998) Genbank Accession No.: S59299 Gene Name: trp Gene Function : Lead Generator (promoter) Reference: Herry, DM et al. "Cloning of the trp gene cluster from a tryptophan-hyperproducing strain of Corynebacterium glutamicum: identification of a mutation in the trp leader sequence," Appl. Environ. Microbiol., 59 (3): 791-799 (1993) Genbank Accession No.: Ull545 Gene Name: trpD Gene Function: Phosphoribosyltransferase anthranilate Reference: O'Gara, J.P. and Dunican, L.K. (1994) Complete nucleotide sequence of the Corynebacterium glutamicum ATCC 21850 tpD gene. "Thesis, Microbiology Department, University College Galway, Ireland Genbank Accession No.: U13922 Gene Name: cglIM; cglIR; clglIR Gene Function: 5 putative type II -cytosoin methyltransferase, putative type II restriction endonuclease, type I or putative type II restriction endonuclease Reference: Schafer, A. et al. "Cloning and characterization of a DNA region encoding a stress-sensitive restriction system from Corynebacterium glutamicum ATCC 13032 and analysis of its role in intergeneric conjugation with Escherichia coli, "J. Bacteriol 176 (23): 7309-7319 (1994); Schafer, A. et al." The Corynebacterium glutamicum cglIM gene encoding a 5-cytosine in an McrBC-deficient Escherichia coli strain, "Gene, 203 (2): 95-101 (1997) Genbank ™ Accession No.: U14965 Gene Name: recA Gene Function: Reference: Genbank Accession No.: U31224 Gene Name: ppx Gene Function: - Reference: Ankri, S. et al. "Mutations in the Corynebacterium glutamicumproline biosynthetic pathway: A natural bypass of the proA step, "J. Bacteriol, 178 (15): 4412-4419 (1996) Genbank Accession No.: U31225 Gene Name: proC Gene Function: L-proline; NADP + 5-oxidoreductase • Reference: Ankri, S. et al. "Mutations in the Corynebacterium glutamicumproline biosynthetic pathway: A natural bypass of the proA step, "J. Bacteriol., 178 (15): 4412-4419 (1996) Access No. to Genbank ™: U31230 Gene Name: obg; proB, unkdh Function of the Gene:?; Gamma glutamyl kinase: similar to D-hydroxy acid dehydrogenase specific for D isomers Reference: Ankri, S. et al. "Mutations in the Corynebacterium glutamicumproline biosynthetic pathway: A natural bypass of the proA step, "J. Bacteriol., 178 (15).-4412-4419 (1996) Genbank Accession No.: U31281 Gene Name: bioB Gene Function: Biotin synthase Reference: Serebriiskii, IG, "Two new nembers of the bio B superfamily: Cloning, sequencing and expression of bio B genes of Methylobacillus flagellatum and Corynebacterium glutamicum, "Gene, 175: 15-22 (1996) Genbank Accession No.: U35023 Gene Name: thtR; accBC Gene Function: Thiosulfate sulfurtransferase; Acyl CoA carboxylase Reference: Jager, W. et al. "A Corynebacterium glutamicum gene encoding a two-domain protein similar to biotin carboxylase and biotin-carboxyl-carrier proteins," Arch.

Microbiol., 166 (2); 76-82 (1996) Genbank Accession No.: U43535 Gene Name: cmr Gene Function: Multiple Drug Resistance Protein Reference: Jager, W. et al. "A Corynebacterium glutamicum gene conferring multidrug resistance in the host heterologous Escherichia coli," J. Bacteriol., 179 (7): 2449-2451 (1997) Access No. to Genbank ™: U43536 Gene Name: clpB Gene Function: Heat shock ATP binding protein Reference: Genbank Accession No.: U53787 Gene Name: aphA-3 Gene Function: 3 '5"-aminoglycoside phosphotransferase Reference: Genbank Accession No.: U39648 Gene Name: - Gene Function: Sequence unidentified Corynebacterium glutamicum involved in histidine biosynthesis, partial sequence Reference: Genbank Accession No.: X04960 Gene Name: trpA; trpB; trpC, trpD; trpE, trpG; trpL Gene Function: Tryptophan Operon Reference: Matsui, K. et al. "Complete nucleotide and deduced amino acid sequences of the Brevibacterium lactofermentum tryptophan operon," Nucleic Acids Res., 14 (24): 10113-10114 (1986) Genbank Accession No.: X07563 Gene Name: lys A Gene Function : DAP decarboxylase (meso-diaminopimelate decarboxylase, EC 4.1.1.20) Reference: Yeh, P. et al. "Nucleic sequence of the lysA gene of Corynebacterium glutamicum and possibie mechanisms for modulation of its expression," Mol. Gen. Genet., 212 (1): 112-119 (1988) Genbank Accession No.: X14234 Gene Name: EC 4.1.1.31 Gene Function: Phosphoenolpyruvate carboxylase Reference: Eik anns, B.J. et al. "The Phosphcenolpyruvate carboxylase gene of Corynebacterium glutamicum: Molecular cloning, nucleotide sequences, and expressicn," Mol. Gen. Genet., 218 (2): 330-339 (1989); Lepiniec, L. et al. "Sorghum Phosphoenolpyruvate carboxylase gene family: structure, function and molecular evolution," Plant. Mol. Biol., 21 (3): 487-502 (1993) Genbank Accession No.: X17313 Gene Name: fda Gene Function: Fructose-bisphosphate aldolase Reference: Von der Osten, C.H. et al. "Molecular cloning, nucleotide sequence and fine-structural analysis of the Corynebacterium glutamicum fda gene: structural comparison of C. glutamicum fructose-1, 6-biphosphate aldolase to class I and class II aldolases, "Mol.Microbial, Genbank Accession No.: X53993 Gene Name: dapA Gene Function: L-2, 3-dihydrodipicolinate synthetase (EC 4. 2.1.52) Reference: Bonnassie, S. et al. "Nucleic sequence of the dapA gene from Corynebacterium glutamicum," Nucleic Acide Res., 18 (21): 6421 (1990) Genbank Accession No.: X54223 Gene Name: - Gene Function: Related Site with AttB Reference: Cianciotto; N. et al. "DNA sequence homology between the B-related sites of Corynebacterium diphtheriae, Corynebacterium ulcerans, Corynebacterium glutamicum, and the attP site of lambdacorynephage," FEMS. Microbiol, Lett., 66: 299-302 (1990) Genbank Accession No.: X54740 Gene Name: argS; lysA Gene Function: Arginyl-tRNA synthetase; Diaminopimelate decarboxylase Reference: Marcel, T. et al. "Nucleotide sequence and organization of the upstream region of the Corynebacterium glutamicum lysA gene," Mol. Microbiol., 4 (11): 1819-1830 (1990) Genbank Accession No.: X55994 Gene Name: trpL; trpE Gene Function: Putative leader peptide; component 1 of anthranilate synthase Reference: Heery, D.M. et al. "Nucleotide sequence of the Corynebacterium glutamicum trpE gene," Nucleic Acids Res., 18 (23): 7138 (1990) Genbank Accession No.: X56037 Gene Name: thrC Gene Function: Threonine synthase Reference: Han, K.S. et al. "The molecular structure of the Corynebacterium glutamicum threonine synthase gene, "Mol.

Microbiol., 4 (10): 1693-1702 (1990) Genbank Accession No.: X56075 Gene Name: attB-related site Gen Function: Fixation Site Reference: Cianciotto, N. et al. "DNA sequence homology between att B-related sites of Corynebacterium diphtheriae, Corynebacterium ulcerans, Corynebacterium glutamicum, and the attP site of lambdacorynephage, "FEMS, Microbiol, Lett., 66: 299-302 (1990) Genbank Accession No. ': X57226 Gene Name: lysC-alpha; lysC-beta; asd Gene Function: Aspartokinase alpha subunit, aspartakinase beta subunit, beta aspartate semialdehyde dehydrogenase Reference: Kalinowski, J. et al. "Genetic and biochemical analysis of the Aspartokinase from Corynebacterium glutamicum," Mol. Microbiol., 5 (5) : 1197-1204 (1991); Kalinowski, J. et al. "Aspartokinase genes lysC alpha and lysC beta overlap and are adjacent to the aspartate beta-semialdehyde dehydrogenase gene asd in Corynebacterium glutamicum," Mol. Gen. Genet., 224 (3): 317-324 (1990) Access No. to Genbank ™: X59403 Name of the Gene: gap; pgk; tpi Gen Function: glyceraidehyde-3-phosphate; phosphoglycerate kinase; triosephosphate isomerase Reference: Eikmanns, B.J. "Identification, sequence analysis, and expression of a Corynebacterium glutamicum gene cluster encoding the three glycolytic enzymes glyceraldehyde-3-phosphate dehydrogenase, 3-phosphoglycerate kinase, and triosephosphate isomers," J. Bacteriol., 174 (19): 6076-6086 ( 1992). Genbank Accession No.: X59404 Gene Name: gdh Gene Function: Glutamate Dehydrogenase Reference: Bormann, E.R. et al. "Molecular analysis of the Corynebacterium glutamicum gdh gene encoding glutamate dehydrogenase," Mol. Microbiol., 6 (3): 317-326 (1992) Genbank Accession No.: X60312 Gene Name: lysl Gene Function: L-lysine permease Reference: Seep-Feldhaus, A.H. et al. "Mclecular analysis of the Corynebacterium glutamicum lysl gene involved in lysine uptake," Mol. Microbiol., 5 (12): 2995-3005 (1991) Genbank Accession No.: X66078 Gene Name: copl Gene Function: Psl Protein Reference: Joliff, G. et al. "Clonir.g and nucleotide sequence of the cspl gene encoding PS1, ene of the two major secreted proteins of Corynebacterium glutamicum: The deduced N-terminal region of PS1 is similar to the Mycobacterium antigen 85 complex, Mol. Microbiol., 6 (l .: 2349-2362 (1992) Genbank Accession No.: X66112 Gene Name: glt Gene Function: Citrate synthase Reference: Eikmanns, BJ et al. "Cloning sequence, expression and tra? Scriptional ar.alysis of the Corynebacterium glutamicum gltA gene encoding citrate synthase, "Microbiol., 140: 1817-1828 (1994 Accession to Genbank ™: X67737 Gene Name: dapB Gene Function: Dihydrodipicolinate reductase Reference: Genbank Accession No.: X69103 Gene Name: csp2 Gene Function: PS2 surface layer protein Reference: Peyret, JL et al. "Characterization of the cspB gene encoding PS2, an ordered surface-layer protein in Corynebacterium glutamicum, "Mol. Microbiol., 9 (1): 97-109 (1993) Genbank Accession No.: X69104 Gene Name: - Gene Function: Insertion element related to IS3 Reference: Bonamy, C. et al. "Identification of IS1206, to Corynebacterium glutamicum IS3-related insertion sequence and phylogenetic analysis," Mol. Microbiol., 14 (3): 571-581 (1994) Access No. to Genbank ™ :: X70959 Gene Name: leuA Gene Function: Isopropylamate Synthase Reference: Patek, M. et al. "Oeucine synthesis in Corynebacterium glutamicum: enzymes activities, structure of leuA, and effect of leuA. inactivation on lysine synthesis, " Appl. Environ. Microbiol., 60 (1): 133-140 (1994) Genbank Accession No. ': X71489 Gene Name: icd Gene Function: Isocitrate dehydrogenase (NADP +) Reference: Eik anns, B. J. et al. "Cloning sequence analysis, expression, and inactivation of the Corynebacterium glutamicum icd gene encoding isocitrate dehydrogenase and biochemical characterization of the enzyme," J. Bacteriol. , 177 (3): 774-782 (1995) Genbank Accession No.: X72855 Gene Name: GDMCT Gene Function: Glutamate dehydrogenase (NADP +) Reference: Genbank Accession No.: X75083, X70584 Gene Name : trA Function of the Gene: resistance to 5-methyltryptophan Reference: Heery, DM et al. "A sequence from a tryptophan-hyperproducing strain of Corynebacterium glutamicum encoding resistance to 5-methyltryptophan," Biochem. Biophys. Beef.

Commun., 201 (3): 1255-1262 (1994) Genbank Accession No.: X75085 Gene Name: recA Gene Function: - Reference: Fitzpatrick, R. et al. "Construction and charactterization of recA mutant strains of Corynebacterium glutamicum and Brevibacterium lactofermentum," Appl.

Microbiol. Biotechnol., 42 (4): 575-580 (1994) Genbank Accession No.: X75504 Gene Name: aceA; thiX Function of the Gene: Partial isocytilate lyase; ? Reference: Reinscheid, D.J. et al. "Characterization of the isocitrate lyase gene from Corynebacterium glutamicum and biochemical analysis of enzyme," J. Bacteriol., 176 (12): 3474-3483 (1994) Genbank Accession No.: X76875 Gene Name: - Gene Function : ATPase beta subunit Reference: Ludwig, W. et al. "Phylogenetic relationships of bacteria based on comparative sequence analysis of elongation factor Tu and ATP-synthase beta-subunit genes," Antonie Van Leeuwenhoek, 64: 285-305 (1993) Genbank Accession No.: X77034 Gene Name: tuf Gene Function: Elongation Factor Your Reference: Ludwig, W. et al. "Phylogenetic relationships of bacteria based on comparative sequence analysis of elongation factur Tu and ATP-synthase beta-subunit genes," Antonie Van Leeuwenhoek, 64: 285-305 (1993) Genbank Accession No.: X77384 Gene Name: recA Function of the Gene: - Reference: Billman-Jacobe, H. "Nucleotide sequence of a recA gene from Corynebacterium glutamicum," DNA Seq. , 4 (6): 403-404 (1994) Genbank Accession No.: X78491 Gene Name: aceB Gene Function: Malate synthase Reference: Reinscheid, D.J. et al. "Malate synthase from Corynebacterium glutamicum pta-ack operon encoding phosphotransacetylase: sequence analysis, "Microbiology, 140: 3099-3108 (1994) Genbank Accession No.: X80629 Gene Name: 16S rDNA Gene Function: 16S ribosomal RNA Reference: Rainey, F.A. et al. "Phylogenetic analysis of the genus Rhodococcus and Norcardia and evidence for the evolutionary origin of the genus Norcadia from within the radiation of Rhodococcus species," Microbiol., 141: 523- 528 (1995) Genbank Accession No.: X81191 Gen: gluA; gluB; gluC; gluD Function of the Gene: Glutamate absorption system Reference: Kronemeyer, W. et al. "Structure of the gluABCD cluster encoding the glutamate uptake system of Corynebacterium glutamicum, "J. Bacteriol., 177 (5): 1152-1158 (1995) Genbank Accession No.: X81379 Gene Name: dapE Gene Function: Succinyldiaminopimelate Deuccinylase Reference: Wehrmann, A. et al." Analysis of different DNA fragments of Corynebacterium glutamicum complementing dapE of Escherichia coli, "Microbiology, 40: 3349-56 (1994) Genbank Accession No.: X82061 Gene Name: 16S rDNA Gene Function: 16S Ribosomal RNA Reference: Ruimy , R. et al. "Phylogeny of the genus Corynebacterium deduced from analyzes of small-subunit ribosomal DNA sequences," Int. J. Syst. Bacteriol. 45 (4): 740-746 (1995) Genbank Accession No. : X82928 Gen Name: asd; lysC Gene Function: Aspartate-semialdehyde dehydrogenase,? Reference: Serebrijski, I. et al. "Multicopy suppression by asd gene and osmotic stress-dependent complementation by heterologous proA in proA mutants," J. Bacteriol., 177 (24): 7255-7260 (1995) Genbank Accession No.: X82929 Gene Name: proA Gene Function: Gamma-glutamylphosphate reductase Reference: Serebrijski, I. et al. "Multicopy suppression by asd gene and osmotic stress-dependent complementation by heterologous proA in proA mutants," J. Bacteriol., 177 (24): 7255-7260 (1995) Genbank Accession No.: X84257 Gene Name: 16S rDNA Gene Function: 16S ribosomal RNA Reference: Pascual, C. et al. "Phylogenetic analysis of the genus Corynebacterium based on 16S rRNA gene sequences," Int.

J. Syst. Bacteriol., 45 (4): 724-728 (1995) Access No. to Genbank ™: X85965 Name of Gene: aroP; dapE Function of the Gene: aromatic amino acid permease; ? Reference: Wehrmann et al. "Functional analysis of sequences adjacent to dapE of C. glutamicum proline reveáis the presence of aPP, which encodes the aromatic amino acid transporter," J. Bacteriol., 177 (20): 5991-? 993 (1995) Access No. Genbank ™: X86157 Gene Name: argB; argC; argD; argF; argj Gen Function: Acetylglutamate kinase, N-acetyl-gamma-glutamyl phosphate reductase; acetylornithine aminotransferase; ornithine carbamoyltransferase; glutamate N-acetyltransferase Reference: Sakanyan, V. et al. "Genes and enzymes of the acetyl cycle of arginine biosynthesis in Corynebacterium glutamicum: enzyme evolution in the early steps of the arginine pathway," Microbiology, 142: 99-103 (1996) Genbank Accession No.: X89084 Gene Name: pta; ackA Gene Function: Phosphate Acetyltransferase; acetate kinase Reference: Reinscheid, D.J. et al. "Cloning, sequence analysis, expression and inactivation of the Corynebacterium glutamicum pta-ack operon encoding phosphotransacetylase and acetate kinase," Microbiology, 145: 503-513 (1999) Genbank Accession No.: X89850 Gene Name: attB Function of the Gen: Fixation site Reference: Le Marrec, C. et al. "Genetic characterization of site-specific integration functions of phi AAU2 infecting" Arthrobacter aureus C70, "J. Bacteriol., 178 (7): 1996-2004 (1996) Genbank Accession No. * M: X90356 Gene Name: Function of the Gene: Fl promoter fragment Reference: Patek, M. et al. "Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif," Microbiology, 142: 1297-1309 (1996) Genbank Accession No. ™: X90357 Gene Name: Gene Function: F2 promoter fragment Reference: Patek, M. et al. "Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for, a consensus motif," Microbiology, 142: 1297-1309 (1996) Access No. to Genbank ™: X90358 Name of Gen: Gene Function: FIO promoter fragment Reference: Patek, M. et al. "Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif," Microbiology, 142: 1297-1309 (1996) Genbank Accession No.: X90359 Gene Name: Gene Function: F13 promoter fragment Reference : Patek, M. et al. "Promoters frem Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif," Microbiology, 142: 1297-1309 (1996) Genbank Accession No.: X90360 Gene Name: - Gene Function: F22 Promoter Fragment Reference: Patek, M. et al. "Prcmoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif," Microbiology, 142: 1297-13C9 (1996) Genbank Accession No.: X90361 Gene Name: Gene Function: F34 Promoter Fragment Reference : Patek, M. et al. "Prcmoters from Corynebacterium glutamicum: cloning, molecular analyeis and search for a consensus motif," Microbiology, 142: 1297-1319 (1996), Genbank Accession No.: X90362 Gene Name: Gene Function: F37 Promoter Fragment Reference: Patek, M. et al. "Promoters from C. glutamicum: cloning molecular analysis and search for a consensus motif," Microbiology, 142: 1297-1309 (1996) Genbank Accession No.: X90363 Gene Name: Gene Function: F45 Promoter Fragment Reference: Patek, M. et al. "Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif," Microbiology, 142.1297-1309 (1996) Genbank Accession No.: X90364 Gene Name: Gene Function: F64 Promoter Fragment Reference: Patek , M. et al. "Promoters from Corynebacteriu glutamicum: cloning, molecular analysis and search for a consensus motif," Microbiology, 142.1297-1309 (1996) Genbank Accession No.: X90365 Gene Name: Gene Function: F75 Promoter Fragment Reference: Patek , M. et al. "Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif," Microbiology, 142.1297-1309 (1996) Genbank Accession No.: X90366 Gene Name: Gene Function: FP101 Promoter Fragment Reference: Patek , M. et al. "Promoters from Corynebacteriur. glutamicum: cloning, molecular analysis and search for a consensus motif, "Microbiology, 142.1297-1309 (1996) Genbank Accession No.: X90367 Gene Name: Gene Function: FP104 Promoter Fragment Reference: Patek, M. et al. al. "Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif," Microbiology, 142.1297-1309 (1996) Genbank Accession No.: X90368 Gene Name: Gene Function: FRIO9 Promoter Fragment Reference : Patek, M. et al. "Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif," Microbiology, 142.1297-1309 (1996) Genbank Accession No.: X93513 Gene Name: amt Function of the Gene: Ammonium Transport System Reference: Siewe, RM et al. "Functional and genetic characterization of the (methyl) ammonium uptake carrier of Corynebacterium glutamicum," J. Biol. Chem., 271 (10): 5398-5403 (1996 ) Genbank ™ Accession Number: X93514 Gen Name: betP Fun of the Gene: Glycine betaine transport system Reference: Peter, H. et al. "Isolation, characterization, and expression of the Corynebacterium glutamicum betP gene, encoding the transport system for the compatible solute glycine betaine," J. Bacteriol., 178 (17): 5229-5234 (1996) Access No. to Genbank ™: X95649 Gene Name: orf4 Gene Function: Reference: Patek, M. et al. "Identification and transcriptional analysis of the dapB-ORF2-dapA-ORF4 operon of Corynebacterium glutamicum, encoding two enzymes involved in L-lysine sinthesis, "Biotechnol.Lett., 19: 1113-1117 (1997) Access No. to Genbank ™: X96 71 Name of Gene: lysE; lysG Function of the Gene: Protein exporting lysine; Lysine export regulatory protein Reference: Vrljic, M. et al. "A new type of transporter with a new type of cellular function: L-lysine export from Corynebacterium glutamicum, "Mol. Microbiol., 22 (5): 815- 826 (1996) Genbank Accession No.: X96580 Gene Name: panB; panC; xylB Gene Function: 3-methyl-2-oxobutanoate hydroxymethyltransferase; pantoate-beta-alanine lyase; xylulokinase Reference: Sahm, H. et al. "D-pantothenate synthesis in Corynebacterium glutamicum and use of panBC and genes encoding L-valine synthesis for D-pantothenate overproduction," Appl. ., 65 (5): 1973- 1979 (1999) Genbank ™ Accession No.: X96962 Gene Name: - Gene Function: IS1207 Insertion Sequence and Transposase Reference: Access No. to Genbank ™: X99289 Gene Name: -Gen Function: Elongation Factor P Reference: Ramos, A. et al. "Cloning, sequencing and expression of the gene encoding elongation factor P in the amino-acid producer Brevibacterium lactofermentum (Corynebacterium glutamicum ATCC 13869), "Gene, 198: 217-222 (1997) Accession No. to Genbank ™: Y00140 Gene Name: thrB Gene Function: Homoserin Kinase Reference: Mateos, LM et al." Nucleotide sequence of the homoserine kinase (thrB) gene of tr.e Brevibacterium lactofermentum, "Nucleic Acids Res., 15 (9): 3922 (1987) Genbank Accession No.: Y00151 Gene Name: ddh Gene Function: Meso-diaminopimelate D-dehydrogenase (EC 1.4.1.16) Reference: Ishino, S. et al. "Nucleotide sequence of the that-diaminopimelate D-dehydrogenase gene from Corynebacterium glutamicum, "Nucleic Acids Res., 15 (9): 3917 (1987) Genbank Accession No.: Y00476 Gene Name: thrA Gene Function: Homoserine dehydrogenase Reference: Mateos, L.M. et al. "Nucleotide sequence of the homoserine dehydrogenase (thrA) gene of the Brevibacterium lactofermentum," Nucleic Acids Res., 15 (24): 10598 (1987) Access No. to Genbank ™: Y00546 Name of Gen: hom; thrB Gene Function: Homoserine dehydrogenase; homoserin kinase Reference: Peoples, O.P. et al. "Nucleotide sequence and fine structural analysis of the Corynebacterium glutamicum hom-thrB operon," Mol. Microbiol., 2 (1): 63-72 (1988) Genbank Accession No.: Y08964 Gene Name: murC; ftsQ / divD; ftsZ Gene Function: UDP-N-acetylmuramate-alanine ligase; split-start protein or cell-division protein; cell division protein Reference: Honrubia, M.P. et al. "Identification, characterization, and chromosomal organization of the ftsZ gene from Brevibacterium lactofermentum," Mol. Gen. Genet. 259 (1): 97-107 (1998) Genbank Accession No.: Y09163 Gene Name: putP Gene Function: High affinity proline transport system Reference: Peter, H. et al. "Isolation of the putP gene the Corynebacterium glutamicumproline and characterization of a low-affinity uptake system for compatible solutes, "Arch.

Microbiol., 168 (2): 143-151 (1997) Genbank Accession No.: Y09548 Gene Name: pyc Gene Function: Pyruvate carboxylase Reference: Peters-Wendisch, P.G. et al. "Piruvate carboxilase from Corynebacterium glutamicum: characterization, expression and inactivation of the pyc gene," Microbiology, 144: 915-927 (1998) Genbank Accession No.: YO9578 Gene Name: leuB Gene Function: 3-isopropyl malate dehydrogenase Reference: Patek, M. et al. "Analysis of the leuB gene from Corynebacterium glutamicum, "Appl. Microbiol. Biotechnol., 50 ((1): 42-47 (1998) Genbank Accession No.: Y12472 Gene Name: Gene Function: Phi-16 bacteriophage binding site Reference: Moreau, S. et al. "Site-specific integration of corynebacterium Phi-16: The construction of an integration vector, "Microbiol., 145: 539-548 (1999) Genbank Accession No.: Y12537 Gene Name: proP Gene Function: Proline Absorption System Protein / ectoine Reference: Peter, H. et al. "Corynebacterium glutamicum is equipped with four secondary carriers for compatible solutes: Identification, sequencing, and characterization of the proline / ectoine uptake system, ProP, and the ectoine / proline / glycine betaine carrier, EctP, "J.

Bacteriol., 180 (22): 6005-6012 (1998) Genbank ™ Accession No. ': Y13221 Gene Name: glnA Gene Function: Glutamine synthetase I Reference: Jakoby, M. et al. "Isolation of Corynebacterium glutamicum glnA gene encoding glutamine eynthetase I," FEMS Microbiol. Lett., 154 (1): 81-88 (1997) Genbank Accession No.: Y16642 Gene Name: lpd Gene Function: Dihydrolipoamide dehydrogenase Reference: Genbank Accession No. ': Y18059 Gene Name: - Function of the Gene: Fixation site of Corinéfago 304L Reference: Moreau, S. et al. "Analysis of the integration functions of φ 304L: An integrase module among • corynephages, "Virology, 255 (1): 150-1? 9 (1999) Genbank Accession No.: Z21501 Gene Name: argS; lysA Gene Function: Arginyl-tRNA synthetase, decarboxylase diaminopimelate (partial) Reference: Oguiza, JA et al. "A gene encoding arginyl-tRNA 10 synthetase is located in the upstream region of the LysA gene in Brevibacterium lactofermentum: Pegulation of argS-lysA cluster expression by arginine," J. Bacteriol., 175 (22 ): 7356-7362 (1993) Genbank Accession No.: Z12502 15 Gene Name: dapA; dapB Gene Function: Dihydrocipicellinate synthase; dihydrodipicolinate reductase (Reference: Pisabarro, A. et al. "A cluster of three genes (dapA, orf2, and dapB) of Brevibacterium lactofermentum. 20 encodes dihydrodipicolinate reductase, and a thirc polypeptide of unknown function, "J. Bacteriol., 175 (9): 2743- 2749 (1993) Genbank Accession No.: Z29563 Gene Name: thrC 25 Gene Function: Threonine synthase Reference: Malumbres, M. et al. "Analysis and expression of the thrC gene of the encoded threonine synthase," Appl.

Environ. Microbiol. 60 (7) 2209-2219 (1994) Genbank Accession No.: Z46753 Gene Name: 16S rDNA Gene Function: Gene for 16S Ribosomal RNA Reference: Genbank Accession No.: Z49822 Gene Name: NEXT Function of the Gene: Sigma Factor SigA Reference: Orguiza, JA et al. "Multiple sigma factor genes in Brevibacterium lactofermentum: Characterization of sigA and sigB," J. Bacteriol., 173 (2): 550-553 (1996) Genbank Accession No.: Z49823 Gene Name: galE; dtxR Gene Function: Catalytic activity of UDP-galactose-4-epimerase; diphtheria toxin regulatory protein Reference: Orguiza, J.A. et al "The galE gene enccdmg the UDP-galactose 4-epimerase of Brevibacterium lactofermentum is coupled transcriptionally to the dmdR gene, "Gene, 177: 103-107 (1996) Genbank Accession No.: Z 9824 Gene Name: orfl, sigB Gene Function:?; eigma factor SigB Reference: Orguiza, J.A. et al "Multiple sigma factor genes in Brevibacterium lactofermentum: Characterization of sigA and SigB," J. Bacteriol., 178 (2): 550-553 (1996) Genbank Accession No.: Z66534 Gene Name: -Function of the Gen: Transposase Reference: Correia, A. et al. "Cloning and characterization of an IS-like element present in the genome of Brevibacterium lactofermentum ATCC 13869," Gene, 170 (1): 91-94 (1996) 1 A sequence for this gene was published in the aforementioned reference. However, the sequence obtained by the inventors of the present application is significantly longer than the published version. It is believed that the published version was based on an incorrect start codon, and therefore represents only a fragment of the actual coding region. TABLE 3: CORYNEBACTERIUM AND BREVIBACTERIUM CEPAS THAT CAN BE USED IN THE PRACTICE OF THE INVENTION Genus Species ATCC FERM NRRL CECT Brevibacterium ammoniagenes 21054 Brevibacterium ammoniagenes 19350 ammoniagenes Brevibacterium 19351 ammoniagenes Brevibacterium 19352 ammoniagenes Brevibacterium 19353 Brevibacterium ammoniagenes 19354 ammoniagenes Brevibacterium 19355 ammoniagenes Brevibacterium 19356 Brevibacterium ammoniagenes 21C55 Brevibacterium ammoniagenes 21077 Brevibacterium ammoniagenes 21553 Brevibacterium ammoniagenes 21530 Brevibacterium ammoniagenes 39101 Brevibacterium butanicum 21196 Brevibacterium divaricatum 21 ~ 92 P928 Brevibacterium flavum 21474 Brevibacterium flavum 21129 Brevibacterium flavum 21518 Brevibacterium flavum B11474 Brevibacterium flavum B11472 Brevibacterium flavum 21127 Brevibacterium flavum 21128 Brevibacterium flavum 21427 Brevibacterium flavum 21475 Brevibacterium flavum 21517 Brevibacterium flavum 21528 Brevibacterium flavum 21? 29 Brevibacterium flavum B11477 Brevibacterium f1avum B11478, Brevibacterium flavum 21127 Brevibacterium flavum B11474 Brevibacterium healii 15527 Brevi bacterium ketoglutamicum 21004 Brevibacterium ketoglutamicu 21089 Brevibacterium ketosoreductum 21914 • Brevibacterium lactofermentum 71 5 Brevibacterium lactofermentum 7 Brevibacterium lactofermentum 7"Brevibacterium lactofermentum 21798 Brevibacterium lactofermentum 21799 Brevibacterium lactofermentum 21800 10 Brevibacterium lactofermentum 21801 Brevibacterium lactofermentum B11470 Brevibacterium lactofermentum B11471 Brevibacterium lactofermentum 21086 Brevibacterium lactofermentum 21420 15 Brevibacterium lactofermentum 21086 Brevibacterium lactofermentum 31269 Brevibacterium linens 9174 • Brevibacterium linens 19391 Brevibacterium linens 8377 20 Brevibacterium paraffinolyticum Brevibacterium spec. Brevibacterium spec. Brevibacterium spec. 14604 Brevibacterium spec. 21860 25 Brevibacterium spec. 21864 Brevibacterium spec. 21865 Brevibacterium spec. 21866 Brevibacterium spec. 19240 Corynebacterium acetoacidophilum 21476 Corynebacterium acetoacidophilum 13870 Corynebacterium acetoglutamicum B11473 Corynebacterium acetoglutamicum BI1475 Corynebacterium acetoglutamicum 15806 Corynebacterium acetoglutamicum 21491 C? > rynebacterium acetoglutamicum 31270 Corynebacterium acetophilum B3671 Corynebacterium ammoniagenes Corynebacterium ammoniagenes 6872 15511 21496 fujioke Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium 39137 21254 21255 Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum 31830 13032 14305 Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum 15455 13058 13059 Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum 13060 21492 21513 Corynebacterium glutamicum Corynebacterium glutamicum 21526 Corynebacterium glutamicum 21543 Corynebacterium glutamicum 13287 5 Corynebacterium glutamicum 21851 Corynebacterium glutamicum 21253 Corynebacterium glutamicum 21514 Corynebacterium glutamicum 21516 Corynebacterium glutamicum 21299 10 Corynebacterium glutamicum 21300 • Corynebacterium glutamicum 39684 Corynebacterium glutamicum 21438 Corynebacterium glutamicum 21649 Corynebacterium glutamicum 21650 15 Corynebacterium glutamicum 19223 Corynebacterium glutamicum 13869 Corynebacterium glutamicum 21157 tf Corynebacterium glutamicum 21158 Corynebacterium glutamicum 21159 20 Corynebacterium glutamicum 21355 Corynebacterium glutamicum 31808 Corynebacterium glutamicum (21674) Corynebacterium glutamicum 21562 Corynebacterium glutamicum 21563 25 Corynebacterium glutamicum 21564 Corynebacterium glutamicum 21565 Corynebacterium glutamicum 21566 Corynebacterium glutamicum 21567 • Corynebacterium glutamicum 21563 5 Corynebacterium glutamicum 21569 Corynebacterium glutamicum 21570 Corynebacterium glutamicum 215 ~ 1 Corynebacterium glutamicum 21572 Corynebacterium glutamicum 215 ~ 3 10 Corynebacterium glutamicum 215 ~ 9 • Corynebacterium glutamicum 19C49 Corynebacterium glutamicum 19C50 Corynebacterium glutamicum 19C? 1 Corynebacterium glutamicum 19C52 15 Corynebacterium glutamicum 19C53 Corynebacterium glutamicum 19054 Corynebacterium glutamicum 19C55 Corynebacterium glutamicum 19C56 Corynebacterium glutamicum 19C57 20 Corynebacterium glutamicum 19C58 Corynebacterium glutamicum 19C59 Corynebacterium glutamicum 19C60 Corynebacterium glutamicum 19135 Corynebacterium glutamicum 13236 25 Corynebacterium glutamicum 21515 Corynebacterium glutamicum 21527 Corynebacterium glutamicum 21544 Corynebacterium glutamicum 21492 Corynebacterium glutamicum B8183 5 Corynebacterium glutamicum B8182 Corynebacterium glutamicum B12416 Corynebacterium glutamicum B12417 Corynebacterium glutamicum B12418 Corynebacterium glutamicum B11476 10 Corynebacterium glutamicum 21608 • Corynebacterium lilium P973 Corynebacterium nitrilophilus 21419 Corynebacterium spec. P4445 Corynebacterium spec. P4446 15 Corynebacterium spec. 31088 Corynebacterium spec. 31089 Corynebacterium spec. 31090 • Corynebacterium spec. 31090 Corynebacterium spec. 31090 20 Corynebacterium spec. 15954 Corynebacterium spec. 21857 Corynebacterium spec. 21862 Corynebacterium spec. Genus Species CBS NCIMB 21863 NCTC ammoniagenee 25 Brevibacterium Brevibacterium ammoniagenes Brevibacterium ammoniagenes Brevibacterium ammoniagenes Brevibacterium ammoniagenes 5 Brevibacterium ammoniagenes Brevibacterium ammoniagenes Brevibacterium ammoniagenes Brevibacterium ammoniagenes Brevibacterium ammoniagenes 10 Brevibacterium ammoniagenes • Brevibacterium ammoniagenes Brevibacterium ammoniagenes butanicum Brevibacterium Brevibacterium flavum divaricatum Brevibacterium flavum 15 Brevibacterium Brevibacterium flavum • Brevibacterium flavum Brevibacterium flavum Brevibacterium flavum Brevibacterium flavum Brevibacterium flavum Brevibacterium flavum Brevibacterium flavum 25 Brevibacterium flavum ? ah áhfc.

Brevibacterium flavum Brevibacterium flavum Brevibacterium flavum Brevibacterium flavum 5 Brevibacterium flavum Brevibacterium healii Brevibacterium ketoglutamicum Brevibacterium ketoglutamicum Brevibacterium ketosoreductum 10 Brevibacterium lactofermentum • Brevibacterium lactofermentum Brevibacterium lactofermentum Brevibacterium lactofermentum Brevibacterium lactofermentum 15 Brevibacterium lactofermentum Brevibacterium lactofermentum Brevibacterium lactofermentum • Brevibacterium lactofermentum Brevibacterium lactofermentum 20 Brevibacterium lactofermentum Brevibacterium lactofermentum Brevibacterium lactofermentum Brevibacterium linens Brevibacterium linens 25 Brevibacterium linens Brevibacterium paraffinolyticum 11160 Brevibacterium spec. 717.73 Brevibacterium spec. 717.73 Brevibacterium spec. Brevibacterium spec. Brevibacterium spec. Brevibacterium spec. Brevibacterium spec. Brevibacterium spec. Corynebacterium Corynebacterium acetoacidophilum acetoacidophilum acetoglutamicum Corynebacterium Corynebacterium Corynebacterium acetoglutamicum acetoglutamicum acetoglutamicum Corynebacterium Corynebacterium ammoniagenes Corynebacterium acetophilum acetoglutamicum Corynebacterium ammoniagenes Corynebacterium fujioke 2399 Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium Corynebacterium glutamicum Corynebacterium glutamicum • Corynebacterium glutamicum 5 Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum 10 Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum 15 Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum fl Corynebacterium glutamicum Corynebacterium glutamicum 20 Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum 25 Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum • Corynebacterium glutamicum 5 Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum 10 Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum 15 Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum Corynebacteriun glutamicum 20. Corynebacterium glutamicum Corynebacteriun glutamicum Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum 25 Corynebacterium glutamicum ^^^ Ai ^^ lt.

Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum • Corynebacterium glutamicum Corynebacterium glutamicum 5 Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum 10 Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum Corynebacterium glutamicum 15 Corynebacterium glutamicum • Corynebacterium lilium Corynebacterium nitrilophilus 11594 20 Corynebacterium spec. Corynebacterium spec. Corynebacterium spec. Corynebacterium spec. Corynebacterium spec. 25 Corynebacterium spec.

Corynebacterium spec. Corynebacterium spec. 20145 Corynebacterium spec. Corynebacterium spec. Corynebacterium spec. ATCC: American Type Culture Collection, Rockville, MD, United States of America. FERM: Fermentation Research Institute, Chiba Japan NRRL: ARS Culture Collection, Northern Regional Research Laboratory, Peoria, IL, United States CECT: Spanish Type Culture Collection, Valencia, Spain NCIMB: National Collection of Industrial and Marine Bacteria Ltd., Aberdeen, United Kingdom CBS: Centraalbureau voor Schimmelcultures, Baarn, NL NCTC: National Collection of Type Cultures, London, United Kingdom United DSMZ: Deutsche Sammiung von Mikroorganismen und Zellkulturen, Braunschweig, Germany For reference see Sugawara, H. et al. (1993) World directory of collections of cultures of microorganisms: Bacteria, fungi and yeasts (4th Edition) World federation for culture collections world data center on microorganisms, Saimata, Japan TABLE 4: RESULTS OF ALIGNMENTS ID # length result of Access Length (NT) Genbank • rxa00051 1527 GB_HTG3: AC009685 210031 AC009685 5 GB_HTG3: AC009685 210031 AC009685 GB_HTG7: AC009511 271896 AC009511 rxa00091 876 GB_BA1: D50453 146191 D50453 GB_BA1: SCI51 40745 AL109848 GB_BA1: EC0UW93 338534 U14003 10 rxa00092 789 GB_BA1: SCH35 45396 AL078610 GB_HTG3: AC011498_ 312343 AC011498 0 GB_HTG3: AC011498_ 312343 AC011498 0 15 rxa00104 879 GB_BA1: MTCY270 37586 Z95388 GB_PL2: T24M8 68251 AF077409 GB_BA1: MTCY270 37586 Z95388 f rxa00113 5745 GB_BA1: MAFASGEN 10520 X87822 GB_BA1: BAFASAA 10549 X64795 20 GB_BA1: MTCY159 33813 Z83863 rxa00164 1812 GB_HTG2: HSJ1153D9 118360 AL109806 GB_HTG2: HSJ1153D9 118360 (AL109806 rxaOOldl 1695 GB_BA1: CGPUTP 3791 Y09163 GB_BA2: U32814 10393 U32814 25 GB BAlrCGPUTP 3791 Y09163 rxa00186 870 GB_PR3: AC004843 136655 AC004843 GB_HTG2: HS745114 133309 AL033532 GB_HTG2: HS745114 133309 AL033532 • rxa00187 474 GB_GSS10: AQ184082 506 AQ184082 5 GB_SS1: CNS008ZZ 1101 AL052951 GB_GSS10: AQ184082 506 AQ184082 rxa00201 292 GB_PR3: HSJ824F16 139330 AL050325 GB_BA1: PCSECA 2724 X89411 GB_EST34: AV122904 242 AV122904 10 rxa00228 714 GB_EST15: AA486042 515 AA486042 • GB_EST15: AA486042 515 AA486042 rxa00243 1140 GB_PR2: CNS01DS5 101584 AL121655 GB_HTG3: AC011408 79332 AC011408 GB_HTG3: AC011408 79332 AC011408 15 rxa00259 2325 GB_HTG1: CEY62E10 254217 AL031580 GB_HTG1: CEY62E10 254217 AL031580 GB_PL2: YSCCHROMI 41986 L22015 f rxa00269 912 GB_HTG4: AC009974 219565 AC009974 GB_HTG4: AC009974 219565 AC009974 20 GB_BA1: AB017508 32050 AB017508 rxa00281 766 GB_BA1: SCE8 24700 AL035654 GB_BA1: SCU51332. 3216 U51332 GB_HTG4: AC011122 187123 AC011122 rxa00298 1968 GB_BA1: CGECTP 2719 AJ001436 25 GB BA1: CGECTP 2719 AJ001436 GB_EST24: AI234006 432 AI234006 rxa00346 813 GB_BA1: SCE2E9 20850 AL021530 GB_BA1: SC9B1 24800 AL049727 GB_BA1: ECU7021 123171 U70214 rxa00368 1698 GB_BA2: AF065159 35209 AF065159 GB_BA1: AE0CHIT1 6861 D63139 GB_EST4: D62996 314 D62996 rxa00369 817 GB_BA1: YP102KB 119,443 AL031866 GB_GSS8: AQ012142 501 AQ012142 GB_HTG2: AC005081 180,096 AC005081 rxa00410 789 GB_BA1: ATPL0CC 8870 Z30328 GB_BA2: U67591 9829 U67591 GB_BA1: TIP0CCQMPJ 4350 M80607 rxa00419 882 GB_BA2: MSU46844 16951 U46844 GB_EST28: AI513245 471 AI513245 GB_HTG4: AC010066 187,240 AC010066 rxa00432 1608 GB_BA1 : BSUB0015 218410 Z99118 GB_PL1: CAC35A5 42565 AL033396 GB_EST13: AA336266 378 AA336266 rxa00449 1704 GB_HTG2: AC008199 124050 AC008199 GB_HTG2: AC008199 124050 AC008199 GB_EO; RATLNKP2 177 M22337 rxa00456 1500 GB_GSS1: FR0030597 476 AL026966 GB_GSS5: AQ786587 556 AQ786587 GB GSS14: AQ526586 434 AQ526586 rxa00477 1767 GB_EST17: AA610489407 AA610489 GB_PR1: HSH33G4 1015 X05857 GB_EST30: AI637667 579 AI637667 rxa00478 954 GB_HTG3: AC008708 83,932 AC008708 GB_HTG3: AC008708 83,932 AC008708 GB_HTG3: AC008708 83,932 AC008708 rxa00480 1239 GB_HTG1: HSJ575L21 94715 7 L096841 GB_HTG1: HSJ575L21 94715 AL096841 GB_RO: AC005960 158414 AC005960 rxa00524 433 GB_BA1: SCI51 40745 AL109848 GB_BA2: AF082879 3434 AF082879 GB_BA1 : BSP132617 5192 AJ132617 rxa00526 813 GB_BA1: BSUB0008 208230 Z99111 GB_BA2: AF012285 46864 AF012285 GB_BA1: D90725 13796 D90725 rxa00559 1140 GB_BA2: CAU77910 3385 U77910 GB_EST4: H34952 382 H34952 GB_BA2: AE000963 22014 AE000963 rxa00570 852 GB_GSS12: AQ422451 563 AQ422451 GB_EST28: AI504741 568 AI504741 GB_EST18: AA712043 68 AA712043 rxa00571 1280 GB_BA1: MTCY78 33818 Z77165 GB_PR3: AC005788 36224 AC005788 GB_PR3: AC005338 34541 AC005338 rxa00590 1288 GB HTG6: AC010932 203273 AC010932 LX? GB_HTG6: AC010932 203273 AC010932 GB_BA1: MSGB26CS 37040 L78816 rxa00591 1476 GB_IN1: CEK09E9 30098 Z79602 • GB_PR4: AF135802 4965 AF135802 GB_PR4: AF104256 4365 AF104256 rxa00596 576 GB_PR3: AC004659 129577 AC004659 GB_PR3: AC004659 129577 AC004659 GB_PR1: HUMCBP2 2047 D83174 rxa00607 504 GB_BA1: MTV010 3400 AL021186 10 GB_BA1: MTV010 3400 AL021186 rxa00623 1461 GB_BA1: MTCY 28 26914 Z81451 GB_BA1: RSPNGR234 34010 Z68203 GB BA2: AE000101 10057 AE000101 rxa00681 15 rxa00690 1269 GB_ _HTG5: AC008338 136685 AC008338 GB_ _HTG4: AC009766 170502 AC009766 GB_ _HTG4: AC009766 170502 AC009766 • rxa00733 1008 GB_ _EST30: AU54038 245 AU054038 GB_ _EST30: AU054038 245 AU054038 20 rxa00735 692 GB_ _BA1: MTCY50 36030 Z77137 GB_ _BA1: D90904 150894 D90904 GB_ _BA1: D90904 150894 D90904 rxa00796 298 GB_ _GSS14: AQ579838 651 AQ579838 GB_ _PR4: AC007625 174701 AC007625 25 GB EST14: AA427576 580 AA427576 rxa00801 756 GB_BA1: MTV022 13025 AL021925 GB_RO: AC002109 160048 AC002109 GB_BA1: MTV022 13025 AL021925 rxa00802 837 GB_GSS14: AQ563349 642 AQ563349 GB_BA1: DIHCLPBA 2441 M32229 GB_GSS3: B61538 698 B61538 rxa00819 1452 GB_HTG3: AC008691_110000 AC008691 1 GB_HTG3: AC008691_110000 AC008691 1 GB_HTG3: AC009127 186591 AC009127 rxa00821 966 GB_HTG1: HS32B1 271488 AL023693 GB_HTG1: HS32B1 271488 AL023693 GB_PR3: AC004919 75547 AC004919 rxa00827 876 GB_EST6: W06539 300 W06539 GB_PR4: AC008179 181745 AC008179 GB_EST18: AA710415 533 AA710415 rxa00842 1323 GB_PR2: AC002379 118595 AC002379 GB_PR2 : AC002379 118595 AC002379 GB_IN1: CEF02D8 31624 Z78411 rxa00847 1572 GB_OV: XELRDS38A 1209 L79915 GB_HTG4: AC007920 234529 AC007920 GB__HTG4: AC007920 234529 AC007920 xa00851 732 GB_HTG2: AC004064 185000 AC004064 GB HTG2: AC004064 185000 AC004064 GB_PR3: HSJ824F16 139330 AL050325 rxa00852 813 GB_HTG3: ACO10120 121582 AC010120 GB_HTG3: AC010120 121582 AC010120 GB_HTG2: AC00689 8 299308 AC006898 rxa00856 rxa00870 1635 GB_BA1: STMMSDA 3986 L48550 GB_PAT: 1192043 713 192 043 GB_PAT: 178754 713 178754 rxa00875 690 GB_BA2: AF119715 549 AF119715 GB_BA2: AE00372 12144 AE000372 GB_BA1: ECU28375 55175 U28375 rxa00878 1986 GB_HTG2: AC007472 114003 AC007472 GB_HTG2: AC007472 114003 AC007472 GB_HTG2: AC006798 207370 AC006798 rxa00880 1968 GB_EST4: H22888 468 H22888 GB_GSS13: AQ426858 516 AQ426858 GB_PR1: AB002335 6289 AB002335 rxa00899 1389 GB_BA1: NGU58849 2401 U58849 GB_BA1: PLPDHOS 3119 L06S22 GB_BAl: PDGINTORF 6747 L06418 rxa00902 1333 GB_GSS15: AQ606873 581 AQ606873 GB_GSS9: AQ163442 658 AQ163442 GB_PL1: PSST70 4974 X69213 rxa00931 969 GB_GSS1: FR0025208 612 AL018047 GB GSS1: FR0021844 252 AL014715 GB_GSS12: AQ403344 593 AQ403344 rxa00941 1440 GB_BA1: MTCY180 44201 Z97193 GB_BA1: MTCY180 44201 Z97193 GB_BA2: MSGKATG 1745 L14268 rxa00962 689 GB_HTG6: AC010998 14433c AC010998 GB_GSS1: GGA340111 990 AJ232089 GB_HTG6: AC010998 144336 AC010998 rxa01060 1047 GB_BA1: ECTTN7 2280 AJ001816 GB_IN2: AF176377 8220 AF176377 GB_GSS10: AQ196728 429 AQ196728 rxa01067 852 GB_BA1: U00016 42931 U00016 GB_BA1: SYCGROESL 3256 D12677 GB_BA1: D90905 13946"D90905 rxa01114 1347 GB_BA1: PSEFA0AB 3480 D10390 GB_BA1: AB014757 6057 AB014757 GB_BA1: SC8D9 38681 AL035569 rxa01136 555 GB_EST1: AA244557 379 AA244557 GB_ EST14: AA407673 306 AA407673 GB_EST26: AI390328 604 AI390328 rxa01138 540 GB_0V: XLXINT1 1278 X13138 GB_PR4: AC006054 143735 AC006054 GB_PR4: AC006054 143735 AC006054 rxa01172 1578 GB_BA1: SCE39 23550 AL049573 GB_BA1: MSU50335 5193 U50335 GB BPressing: BACTHRTRN 15467 D84213 rxa01191 1713 GB_PR2: HS1191B2 60823 AL022237 GB_PR2: HS1191B2 60823 AL022237 rxa01205 554 GB_BA1: MTCY373 35516 Z73419 GB_PL1: ATY12776 38483 Y12776 GB_PL2: ATT6K21 99643 AL021889 rxa01212 1047 GB_BA2: SCD25 41622 AL118514 GB_BA1: SLGLYUB 2576 X65556 GB_BA1: SCH10 39524 AL049754 rxa01219 1005 GB_PAT: A68024 520 A68024 GB_PAT: A68025 193 A68025 GB_PAT: A68027 193 A68027 rxa01220 1200 GB_PR3: HS5112B11 64356 AL031058 GB_EST6: N99239 424 N99239 GB_EST16: AA554268 400 AA554268 rxa01221 849 GB_PR4: AF179633 96371 AF179633 GB_VI: EHVU20824 184427 U20824 GB_BA2: AE000407 106C1 AE000407 rxa01222 822 GB_PAT: AR068625 28804 AR068625 GB_BA2 : SSU511197 28804 U51197 GB_IN1: BBU44918 2791 U44918 rxa01260 1305 GB_BA1: CGLPD 1800 Y16642 GB _BA1: MTV038 16094 AL021933 GB_PR3: AC005618 176714 AC005618 rxa01261 294 GB BPressing: CGLPD 1800 Y16642 GB__HTG4: AC010045 164829 AC010045 GB_ _HTG4: AC010045 164829 AC010045 rxa01269 564 GB_ _BA2: AF125164 26443 AF125164 GB_ _BA1: AB002668 24907 AB002668 GB_ _BA1: AB010415 23112 AB010415 rxa01291 1056 GB_ _STS: AU027820 238 AU027820 GB_ _STS: AU027820 238 AU027820 GB_ _HTG3: AC006445 174547 AC006445 rxa01292 1308 GB_ _BA1: BSUB0017 217420 Z99120 GB_ _HTG3: AC010580 121119 AC010580 GB_ _HTG3: AC010580 12119 AC010580 rxa01293 450 GB_ _GSS8: AQ001809 705 AQ001809 GB_ _GSS8: AQ001809 705 AQ001309 rxa01339 1111 GB_ _PL1: MGU60290 4614 U60290 GB_ _HTG3: AC011371 189,187 AC011371 GB_ _HTG3: AC011371 189,187 AC011371 rxa01382 1192 GB_ _HTG4: AC009892 138122 AC009892 GB_ _HTG4: AC009892 138122 AC009392 GB_ _PR3: AC002416 128,915 AC002416 rxa01399 1142 GB_ _EST9: AA096601 524 AA0096601 GB_ _EST37: AI982114 626 AI982114 GB_ _OV: GGU20766 1645 U20766 rxa01420 1065 GB_ _HTG2: AC005690 193424 AC005690 GB_ _HTG2: AC005690 193424 AC005690 GB HTG2: AC006637 22092 AC006637 rxa01467 414 GB_HTG1: CEY102G3 11000 AL020985 GB_HTG1: CEY102G3 11000 AL020985 GB_HTG1: CEY113G7_ 11000 AL031113 rxa01576 885 GB_BA2: AF030975 2511 AF030975 GB_BA2: AF030975 2511 AF030975 GB_EST22: AI068560 965 AI068560 rxa01580 840 GB_GSS14: AQ554460 681 AQ554460 GB_IN2: AC005449 85518 AC005449 GB IN2: AC005449 85518 AC005449 rxa01584 rxa01604 771 GB_ _HTG3: AC011352 16016"AC011352 GB_ _HTG3: AC011352 16016" AC011352 GB_ _HTG3: AC011402 168865 AC011402 rxa01614 1146 GB_ _BA1: CGA224946 2408 AJ224946 GB_ _EST17: AA608825 439 AA608825 GB_ _PR4 : AC005377 102311 AC005377 rxa01629 1635 GB_ _BA1: CGPROPGEN 2936 Y12537 GB_ _BA1: CGPROPGEN 2936 Y12537 GB_ _PR4: AF191071 88481 AF191071 rxa01644 1401 GB_ _BA1: MSGB577C0 37770 L0I263 S GB_ _BA1: MLCB2407 35615 AL023596 GB_ _BA1: MTV025 121125 ALC22121 rxa01667 1329 GB_ _BA1: CGU43536 3464 U43536 GB HTG4: AC009841 164434 AC009841 GB_HTG4: AC009841 164434 AC009841 rxa01722 1848 GB_GSS1: FR0022586 522 AL015452 GB_GSS1: FR0022584 485 AL015450 GB_IN1: CET26H2 37569 Z82055 rxa01727 1401 GB_BA2: C0RCSLYS 2821 M89931 GB_HTG6: AC011037 167849 AC011037 GB_HTG6: AC011037 167849 AC011037 rxa01737 1182 GB_BA1: SCGD3 33779 AL096822 GB_HTG1: CNS01DSB 222193 AL121768 GB_HTG1: CNS01DSB 222193 AL121768 rxa01762 1659 GB_BA1: MTCI28 36300 Z97050 GB_BA1: SC6G10 36734 AL049497 GB_BA1: SCE29 26477 AL035707 rxa01764 1056 GB_PL2: SPAC343 42947 AL109739 GB_PL2: SPAC343 42947 AL109739 rxa01801 1140 GB_EST38: AW066306 334 AW066306 GB_GSS13: AQ484750 375 AQ484750 GB_GSS13: AQ489971 252 AQ489971 rxa01823 900 GB_BA1: SCI51 40745 AL109848 GB_BA1: ECU82598 136,742 U82598 GB_BA1: BSUB0018 209,510 Z99121 rxa01853 675 GB_BA1: MTCY227 3594.6 Z77724 GB_HTG3: AC010189 265962 AC010189 GB_HTG3: AC010189 265962 AC0101 89 rxa01881 558 GB HTG4: AC011117 148447 AC011117 GB_HTG4: AC011117 148447 AC011117 GB_BA1: MTCY2B12 20431 Z81011 rxa01894 978 GB_BA1: MTCY274 39991 Z74024 GB_IN1: CELF46H5 38886 U41543 GB__HTG3: AC009204 115633 AC009204 rxa01897 666 GB_HTG1: CEY48B6 293827 AL021151 GB_HTG1: CEY48B6 293827 AL021151 GB_HTG1: CEY53F4_2 110000 Z92860 rxa01946 1298 GB_BA1: MTV007 32806 AL021184 GB_BA1: SC5F2A 40105 AL049587 GB_BA1: SCARD1GN 2321 X84374 rxa01980 756 GB_PL2: AC008262 99698 AC008262 GB_PL1: AB013388 73428 AB013388 GB_PL1: AB013388 73428 AB013388 rxa01983 630 GB_HTG4: AC006467 175695 AC006467 GB_HTG4: AC006467 175695 AC006467 GB_HTG4 : AC006467 175695 AC006467 rxa02020 1111 GB_BA1: CGDNAAROP 2612 X85965 GB_PAT: A58887 1612 A58887 GB_BA1: STYCARABA 4378 M95047 rxa02029 1437 GB_HTG2: AC003023 104768 AC003023 GB_HTG2: AC0Q3023 104768 AC003023 GB_HTG2: HS118B18 104729 AL034344 rxa02030 1509 GB_PR4: AC007695 63247 AC007695 GB PR4: AC006464 99908 ac006464 «A- SGFC GB_ PR4: AC006464 99908 ac006464 rxa02073 GB_BA1 1653: 2037 CGGDHA X72855 GB_BA1: X59404 2037 CGGDHA GB_BA2: 25970 SC2H4 AL031514 rxa02074 rxa02095 1527 GB_EST18: AA703380 AA703380 471 GB_HTG6: 122911 AC009769 AC009769 GB_EST7: W70175 W70175 rxa02099 436 373 GB_BA1: CAJ10319 5368 AJ010319 GB_HTG3: AC011509 111353 AC011509 GB_HTG3: AC011509 111353 AC011509 rxa02115 1197 GB_HTG5: AC010126 175,936 AC010126 GB_HTG5: AC010126 175986 AC010126 GB_PR1: HUMHM145 2214 D10925 rxa02128 1818 GB_BA1: MTCY190 34150 Z70283 GB_BA1: MTCY190 34150 Z70283 GB_GSS10: AQ161109 738 AQ161109 rxa02133 329 GB_BA2 : MPAE000058 28530 AE000058 GB_HTG4: AC008308 151,373 AC008308 GB_HTG4: AC008308 151,373 AC00830d rxa02150 924 GB_EST37: AW012260 358 AW012260 GB _GSS3: B87734 389 B87734 GB_PR4: AC005042 192,218 AC005042 rxa02171 1776 BA2: AF010496 189370 AF010496 GB EST24: AI170522 367 AI170522 GB_PL1: PHVDLECA 1411 K03288 rxa02173 1575 GB_BA1: CGGLTG 3013 X66112 GB_BA1: CGGLTG 3013 X66112 GB_BA2: AE00010 4 10146 AE000104 rxa02224 1920 GB_BA2: CXU21300 8990 U21300 GB_HTG3: AC009185 87184 AC009185 GB_HTG3: AC009185 87164 AC009185 rxa02225 905 GB_BA2: MPAE000058 28530 AE000058 GB_EST26: AI337275 618 AI337275 GB_EST26: AI337275 618 AI337275 rxa02233 1410 GB_BA1: ERWPNLB 1291 M65057 GB_EST30: AV021947 313 AV021947 GB_EST33 : AV087117 251 AV087117 rxa02253 1050 GB_EST11: AA250210 532 AA250210 GB_EST11: AA250210 532 AA250210 rxa02261 1479 GB_BA1: CGL007732 4460 AJ007732 GB_BA1: CGAMTGENE 2028 X93513 GB_BA1: CORPEPC 4885 M25819 rxa02263 1023 GB_PL2: AF087130 3478 AF087130 GB_EST30: AI663709 408 AI663709 GB_RO: AF074714 3120 AF074714 rxa02269 1095 GB: GSS4: AQ742825 847 AQ742825 GB: HTG3: AC009293 162944 AC009293 GB: HTG3: AC009293 162944 AC009293 rxa02309 1173 GB BA1: MTY25D10 40836 Z95558 GB_BA1: MSGY224 40051 AD0000054 GB_HTG2: AC007163 186618 AC007163 rxa02310 1386 GB_BA1: MTY25D10 40838 Z95558 GB_BA1: MSGY224 40051 AD0000054 GB_PR3: HS279N11 169998 Z98255 rxa02321 1752 GB_BA1: AB018531 4961 AB0 18531 GB_PAT: E17019 4961 E17019 GB_BA1: AB018530 2855 AB018530 rxa02335 1896 GB_BA1: CGU35023 3195 U35023 GB_BA1: U00012 33312 U00012 GB_BA1: MTCY71 42729 Z92771 rxa02364 750 GB_BA1: AP000006 319000 AP000006 GB_BA1: AP000006 319000 AP000006 rxa02372 2010 GB_HTG3: AC011461 100974 AC011461 GB_HTG3: AC011461 100974 AC011461 GB_EST21: AA992021 279 AA992021 rxa02397 1119 GB_HTG4 : AC009273 76175 AC009273 GB_HTG4: AC009273 76175 AC009273 GB_BA1: D90826 19493 D90826 rxa02424 723 GB_EST13: AA334108 275 AA33410d GB_PR3: AC005224 166687 AC005224 GB_PR3: AC005224 166687 AC005224 rxa02426 1656 GB_PAT: A06664 1350 A06664 GB_PAT: A04115 1361 A04115 GB BA1: BACLDHL 1361 M14788 rxa024d7 1827 GB_BA2: AF007101 32870 AF007101 GB_BA1: MTCI364 29540 Z93777 GB_BA2: AF119621 15986 AF119621 rxa02511 780 GB_PR4: AC002470 235395 AC002470 GB_PR4: AC002472 147100 AC002472 GB_EST34: AI806936 118 AId0693d rxa02512 1086 GB_BA1: MTCY1A10 25949 Z95387 GB_BA1: MLCL581 36225 Z96801 GB_OV: GGU13396 2738 U43396 rxa02527 1452 GB_BA2: AF008220 220060 AF008220 GB_BA2: AF00d220 220060 AF008220 GB_HTG2: AC005861 112,369 AC005861 rxa02547 2262 GB_PL1: AB006530 7344 AB006530 GB_PL1: CNASA 5729 D85624 GB_PL1: AB006530 7344 AB006530 rxa02566 1332 GB_EST32: AI727189 619 AI727189 GB_BA1: CGPUTP 3791 Y09163 GB_PL2: SPAC13G6 33481 Z5430d rxa02571 1152 GB_BA1: CGU43535 2531 U43535 GB_EST35: AI857365 488 AId57385 GB_BA1: CGU43535 2531 U43535 rxa02578 1227 GB_PL1: AB016871 79109 AB016871 GB_PL1: AB25602 55790 AB25602 GB_IN1: CELF36H9 35985 AF016668 rxa02581 1983 GB BA1: MTV005 37840 AL010186 GB_BA1: MTV005 37840 AL010186 rxa02562 4953 GB_BA1: MTV026 23740 AL022076 GB_BA1: MTCY338 29372 Z74697 GB_BA1 : SEERYABS 20444 X62569 rxa02563 1671 GB_BA2: AF113605 1593 AF113605 GB_BA1: SC1C2 42210 AL031124 GB_BA1: AB018531 4961 AB018531 rxa02599 600 GB_BA1: AEMML 2585 X99639 GB_EST15: AA508926 422 AA508926 GB_BA1: AEMML 2585 X99639 rxa02634 1734 GB_BA1: SYNPOO 1964 X17439 GB_GSS9: AQ101527 184 AQ101527 GB_IN1: MNE133341 399 AJ133341 rxa0263d 999 GB_BA2: AE001756 10938 AE001756 GB_GSS12: AQ4238 78689 AQ423378 GB_HTG2: AC006765 274498 AC006765 rxa02659 335 GB_EST36: AI900317 436 AI900317 GB_GSS12: AQ342831 683 AQ342331 GB_EST36: AI900856779 AI900356 rxa02676 1512 GB_IN2: CELB0213 39134 AF039050 GB_GSSl: CNSSOOPZB 364 AL035157 GB_RO: RNITPR2R 10708 X61677 rxa02677 882 GB_RO: D89728 5002 D89728 GB_GSS8: AQ062004 362 AQ062004 GB GSS14: AQ555818 462 AQ555818 . t í * rxa02691 930 GB_IN1: DME9736 7411 AJ009736 GB_PR4: AC004801 193561 AC004801 GB_PR4: AC004801 193561 AC004801 rxa02718 1170 GB_EST34: AV132028 258 AV132026 GB_GSS10: AQ240654 452 AQ240654 GB_GSS11: AQ309500 576 AQ309500 rxa02749 999 GB_BA2: AF086791 37867 AF086791 GB_BA1: SYCSLRB 146271 D64000 GB_BA2 : AE001306 13316 AE001306 10 rxa02767 906 GB_BA2: AF126953 1638 AF126953 • GB_BA1: SC15 6661 AL079332 GB_PR3: HS90L6 19083"'Z97353 rxa02792 676 GB_BA2: AF099015 5000 AF099015 GB_BA1: AC0UW93 338534 U14003 15 GB_HTG3: AC011361 186148 AC011361 rxa02794 1197 GB_PR4: AC005998 96556 AC005998 GB_PR4: AC006008 57554 AC006008 • GB_PR3: HSDJ73H14 95556 AL080272 rxa02d09 375 GB_RO: MUSSPCTLT 3172 M22527 20 GB_RO: MUSGRC 894 M18459 GB_RO: RNU57062 880 U57062 rxa02811 484 GB_GSS6: AQ832862 476 AQ832362 GB_GSS5: AQ784593 515 AQ784593 GB_GSS13: AQ473140 397 AQ473140 25 rxa02836 678 GB EST18: AA696785 316 AA696785 GB_EST18: AA696785 316 AA696785 rxa03212 1452 GB_BA1: CGBETPGEN 2339 X93514 GB_BA1: SC5F2A 40105 AL049587 GB_BA2: AF008220 220060 AF008220 rxs03220 725 GB_PL1: CKHUP2 2353 X66855 GB_EST38: AW048153 383 ~ AW04dl53 GB_PL1: CKHUP2 2353 X66855 ID # Genbank result name rxa00051 Homo sapiens, chromosome 15 clone 91_E_13 map 15, *** SEQUENCING IN PROGRESS ***, 27 non-ordered parts. Homo sapiens, chromosome 15 clone 91_E_13 map 15, *** SEQUENCING IN PROGRESS ***, 27 non-ordered parts. Homo sapiens clone RP11-860B13, *** SEQUENCING IN PROGRESS ***, 59 non-ordered parts. rxa00091 Bacillus subtilis DNA for region of 25-36 degrees containing the amyE-srfA region, complete cds. Streptomyces coelicolor, cosmid 151. Escherichia coli K-12, chromosomal region of 92.3 a 00. 1 minutes rxa00092 _ Streptomyces coelicolor, cosmid H35. Homo sapiens chromosome 19 clone CIT978SKB_50L17, *** SEQUENCING IN PROGRESS ***, 190 non-ordered parts.

Homo sapiens chromosome 19 clone CIT978SKB_50L17, *** SEQUENCING IN PROGRESS ***, 190 non-ordered parts. rxa00104 Mycobacterium tuberculosis H37Rv complete genome; segment 96/162. Arabidopsis thaliana BAC T24M8. Mycobacterium tuberculosis H37Rv complete genome; segment 96/162. rxa00113 B. ammoniagenes FAS gene. B. ammoniagenes FAS gene. Mycobacterium tuberculosis H37Rv genema complete- segment 111/162. rxa00164 Homo sapiens chromosome 20 clone RP5-1153D9, *** SEQUENCE IN PROGRESS ***, in unordered parts. Homo sapiens chromosome 20 clone RP5-1153D9, *** SEQUENCING IN PROGRESS ***, in unordered parts. Homo sapiens cromosom 20 clone RP5-1153D9, *** SEQUENCING IN PROGRESS ***, in non-ordered parts. rxaOOldl C. glutamicum gene putP. Haemophilus influenzae Rd section 129 of 163 of the complete genome. C. glutamicum gene putP. rxa00186 Homo sapiens PAC clone DJ0612F12 of 7pl2-pl4, complete sequence. Homo sapiens chromosome 1 clone RP4-745I14 map q23 1-24.3, *** SEQUENCING IN PROGRESS ***, in non-ordered parts. Homo sapiens chromosome 1 clone RP4-745I14 map q23 1-24.3, *** SEQUENCING IN PROGRESS ***, in non-ordered parts. rxa00187 HS_3216_A1_G06_T7 CIT Approved Human Genomic Sperm Library D Homo sapiens genomic clone plate = 3216 col = 15 row = M, genomic research sequence. Drosophila melanogaster B7 extreme genomic research sequence from BAC # BACR18L01 from RPCI-98 library of Drosophila melanogaster (fruit fly), genomic research sequence. HS_3216_A1_G08_T7 CIT Approved Human Genomic Sperm Library D Homo sapiens genomic clone plate = 3216 col = 15 row = M, genomic research sequence. rxa00201 Human DNA sequence of clone 824F16 on chromosome 20, complete sequence. R. capsulatus DNA for gene secA. AV122904 Mus musculus C57BL / 6J 10-day embryos Mus musculus cDNA clone 2610529H07, sequence MRNA. rxa00223 ab40c08.rl Stratagene cell HeLa s3 937216 Homo sapiens cDNA clone IMAGE: 843278 5 ', mRNA sequence. ab40c08.rl Stratagene cell HeLa s3 937216 Homo sapiens cDNA clone IMAGE: 843278 5 ', sequence MRNA. rxa00243 BAC sequence from candidate region SPG4 at 2p21-2p22, complete. Homo sapiens, clone CIT978SK3_65D22, *** SEQUENCING IN PROGRESS ***, 10 non-ordered parts. Homo sapiens, clone CIT978SK3_65D22, *** SEQUENCING IN PROGRESS ***, 10 non-ordered parts. rxa00259 Caenorhabditis elegans chromosome IV clone Y62E10, *** SEQUENCING IN PROGRESS ** ', in non-ordered parts. Caenorhabditis elegans chromosome IV clone Y62E10, *** SEQUENCING IN PROGRESS ** ", in non-ordered parts. Saccharomyces cerevisiae chromosome I sequence of right arm and centromere. rxa00269 Homo sapiens chromosome unknown clone NH0459I19, SEQUENCE OF DRAFT WORK, in unordered parts. Homo sapiens chromosome unknown clone NH0459I19, SEQUENCE OF DRAFT WORK, in unordered parts. Bacillus halodurans C-125, genomic DNA, 32 kb fragment, complete cds. rxa00281 Streptomyces coelicolor, cosmid E8. Streptomyces coelicolor, histidine kinase homologue genes (absAl) and response regulator homologue (absA2), complete cds. Homo sapiens chromosome 8 clone 23_D_19 map 8, *** SEQUENCING IN PROGRESS ** ', 27 ordered parts. rxa00298 Corynebacterium glutamicum gene ectP. Corynebacterium glutamicum gene ectP. EST230694 normalized rat lung, Bento Soares Rattus sp, cDNA clone RLUCU01 3 'end, mRNA sequence. rxa00346 Streptomyces coelicolor, cosmid 2E9. Streptomyces coelicolor, cosmid 9B1. Escherichia coli chromosome minutes 4-6. rxa00368 Bradyrhizobium japonicum putative arylsulfatase genes (arsA), putative precursor of soluble litholy transglicosylase (sltA), dihydropicolinate synthase (dapA), MscL (mscL), SmpB (smpB), BcpB (bcpB), RnpO (rn? 0), homolog of RelA / Spo T (relA), PdxJ (pdxJ, and acyl carrier protein synthase AcpS (acps), complete cds, prokaryotic type I signal peptidase gene SipF (sipF), sipF-sipS allele, complete cds; RNase III gene (rnc), complete cds, GTP binding protein gene Era (era), partial cds, and unknown genes Aeromonas sp, gene for chitinaea, complete and partial cds HUM347G01B Clontech mRNA polyA- of human aorta (# 6572) Homo sapiens, clone cDNA GEN-347G01 5 ', sequence of .ARNm rxa00369 Yersinia pestis unstable region of 102 kbases: from 1 to 119443. 8750H1A037010396 ce library of chromosome II genomic clone of Rhodobacter sphaeroides 8750H1A037010398, sequence of genomic research Homo sapiens clone RG270D13, * ** 5 EQUESCIENCE IN PROGRESS ***, 18 parts not ordered. rxa00410 A. tumefaciens plasmid Ti pTiAch5 gene for OccR, OccQ, OccM, OccP, OccT, OoxB, OoxA and ornithine cyclodesaminase.

Methanococcus jannaschii section 133 of 150 of the complete genome. Plasmid pTiA6 (from Agribacterium tumefaciens), • octopine permease genes of periplasmic type 5 (occR, occQ, occM, occP, and occJ) and lysR regulatory protein genes (occR), complete cds. rxa00419 Mycobacterium smegmatis catalase-peroxidase (katG) genes, putative arabinosiltransferase 10 (embC, embA, embB), complete cds and putative propionyl-coA carboxylase beta chain genes (pccB), partial cds. GH13311.3 'GH Drosophila melanogaster, head pOT2 Drosophila melanogaster cDNA clone GH133 °° 3', 15 mRNA sequence. Drosophila melanogaster chromosome 3L / 72A4 clone RPCI98-2501, *** SECTION IN PROGRESS ***, f 70 unordered parts. rxa00432 Bacillus subtilis complete genome (section 15 of 20 21): from 2795131 to 3013540. C. albicans cosmid Ca35A5. EST40981 Homo sapiens cDNA 5 'extreme endtr etrial tumor, mRNA sequence. rxa00449 Drosophila melanogaster chromosome 3, clone BACR01K08 25 (D756) RPCI-98 01. K.8 map 94D-94D strain y; cn bw sp, * * * SECUENC I MENT IN PROGRESS * * *, 83 non-ordered parts. Drosophila melanogaster chromosome 3, clone BACR01K08 (D756) RPCI-98 01. K 8 map 94D-94D strain y; cn bw sp, * * * SEQUENCING IN PROGRESS * * *, 83 non-ordered parts. Rat binding protein gene, exon 2 rxa00456 Fugu rubripes GSS sequence, clone 091C22aF9, genomic research sequence. HS_3086_B1_H05_MR CIT Approved Human Genomic Sperm Library D Homo sapiens genomic clone plate = 3086 col = 9 row = P, genomic research sequence. HS_5198_B1_B03_SP6E RPCI-11 Human Male BAC Library Homo sapiens genomic clone plate = 774 col = 5 row = D, genomic research sequence. rxa00477 np93e05.sl NCI_CGAP_Thyl Homo sapiens cDNA clone IMAGE: 1133888 similar to gb: M11353 HISTONE H3.3 (HUMAN); mRNA sequence. Gene H3.3 of human exon 4. ttlOgll.xl NCI_CGAP_GC6 Homo sapiens cDNA clone IMAGE: 2240420 3 'mRNA sequence, rxa00478 Homo sapiens chromosome 5 clone CIT978SKB_78F1, *** SEQUENCING IN PROGRESS ***, 12 unordered parts. __, ^ '_ ^ ___ ¿_ ____ Homo sapiens chromosome 5 clone CIT973SKB_78F1, *** SEQUENCING IN PROGRESS t **, 12 non-ordered parts. Homo sapiens chromosome 5 clone iT978SKB_78Fl, *** SEQUENCING IN PROGRESS t **, 12 unordered parts. rxa00480 Homo sapiens chromosome 1 clone RP4-575L21, *** SEQUENCING IN PROGRESS ***, unordered parts. Homo sapiens chromosome 1 clone RP4-575L21, *** SEQUENCING IN PROGRESS ***, unordered parts. Mus musculus chromosome 17 BAC citb20h22 from the MHC region, complete sequence. rxa00524 Streptomyces coelicolor, cosmid 151. Yersinia enterocolitica group of enteroqueline gene / ABC transporter enterobactin, complete sequence. Burkholderia sp, P transporter operon and flank genes. rxa00526 Bacillus subtilis complete genome '. section 8 of 21): from 1394791 to 1603020. Bacillus subtilis region of mobA-nprE gene. Escherichia coli genomic DNA (19.7 - 20.0 min). rxa00559 Corynebacterium ammoniagenes sequence upstream of the 5-phosphoribosyl-1-pyrophosphate amidotransferase gene (purF). EST108261 Rat PC-12 cells, Rattus sp cDNA • untreated clone RPCCK07 similar to 23 5 kDa precursor of complex I of NADH-ubiquinone oxidoreductase (iron-sulfur protein), mRNA sequence. Archaeoglobus fulgidus section 144 of 172 of the complete genome. rxa00570 RPCI-11-185C3. TV RPCI-11 genomic clone of Homo 10 sapiens RPCI-11-185C3, research sequence • genomics vlldcOl.xl Stratagene mouse T cell 937311 Mus musculus, cDNA clone IMAGE: 972384 3 'similar to gb: Z14044 M. musculus, mRNA for protein containing valosin (MOUSE); mRNA sequence. vu29fl0.rl Barstead mouse microtube MPLRB5 Mus musculus cDNA clone IMAGE: 1182091 5 'similar to f gb: L05093 60S RIBOSOMAL PROTEIN L18A (HUMAN); mRNA sequence. 20 rxa00571 Mycobacterium tuberculosis H37Rv complete genome; segment 145/162. Homo sapiens, chromosome 19, cosmid R26652, complete sequence. Homo sapiens, chromosome 19, cosmid R31646, 25 complete sequence. rxa00590 Homo sapiens, chromosome 15 clone RP11-296E22 map 15, *** SEQUENCING IN PROGRESS ***, 36 unordered parts. • Homo sapiens, chromosome 15 clone RP11-296E22 map 5 15, *** SEQUENCING IN PROGRESS ***, 36 non-ordered parts. Mycobacterium leprae cosmid B26 DNA sequence. rxa00591 Caenorhabditis elegans cosmid K09E9, complete sequence. 10 Homo sapiens mRNA complex component • protein associated with thyroid hormone receptor TRAP170, complete cds. Homo sapiens transcriptional co-activator mRNA CRSP150 (CRSP150), complete cds. 15 rxa00596 Homo sapiens chromosome 19, clone CIT-HSP-87ml7 BAC, complete sequence. Homo sapiens chromosome 19, clone CIT-HSP-87ml7 BAC, complete sequence. MRNA from human to collagen-binding protein 2, complete cds. rxa00607 Mycobacterium tuberculosis H37Rv complete genome; segment 119/162. Mycobacterium tuberculosis H37Rv complete genome; segment 119/162. rxa00623 Mycobacterium tuberculosis H37Rv complete genome; segment 107/162. Rhizobium sp. plasmid NGR234a DNA. • Rhizobium sp. NGR234 plasmid pNGR234a, section 38 5 of 46 of the complete plasmid sequence. rxa00681 rxa00690 Drosophila melanogaster chromosome X clone BACR30J04 (D908) RPCI-98 30. J.4 map 19C-19E, strain y; cn bw sp, *** SECUENC IAMI ENTO IN PROGRESS ***, 93 parts á- 10 unordered. Homo sapiens chromosome 11 clone 404_A_03 map 11, *** SEQUENCING IN PROGRESS ***, 27 unordered parts. Homo sapiens chromosome 11 clone 404_A_03 map 11, 15 *** SEQUENCING IN PRCGRESO ***, 27 unordered parts. rxa00733 AU054038 Dictyostelium discoideum SL (H.

• Urushihara) cDNA of Dictyostelium discoideum clone SLK472, sequence of 7RNA. 20 AU054038 Dictyostelium discoideum SL (H. Urushihara) Dictyostelium discoideum cDNA clone SLK472, mRNA sequence. rxa00735 Mycobacterium tuberculosis H37Rv complete genome; segment 55/162. 25 Synechocystis sp. PCC6803 complete genome, 6/27, 630555-7dl448. Synechocystis sp. PCC6803 complete gene, 6/27, 630555-781448. rxa00796 T135342b sub-library of clone BAC 31P06, genomic clone of Medicago truncatula 31-P-06-C-054, genomic research sequence. Genomic sequence of Homo sapiens clone 2314F2 of chromosome 18, complete sequence. zw54b04.sl Soares_total_fetus_Nb2HF8_9w Homo sapiens cDNA clone IMAGE: 773539 3 'similar to gb: M86852 FACTOR 1 OF ENSAOLE OF PEROXISOMA (HUMAN); mRNA sequence. rxaOOdOl Mycobacterium tuberculosis H3 ~? v complete genome; segment 100/162. Genomic sequence of mouse 9, complete sequence. Mycobacterium tuberculosis H3"? V complete genome; segment 100/162. rxa00602 HS_5335_B2_A09_T7A RPCI-11 Human Male BAC Library Homo sapiens, genomic clone of Hemo sapiens plate = 91 col = 18 row = B, genomic research sequence. B. nodosus clpB gene encoding an ATP-dependent protease regulatory subunit. T17M17TR TAMU genomic clone of arabidopsis thaliana T17M17, genomic research sequence. rxa00819 Homo sapiens, chromosome 5 clone CIT978SKB_63A22, *** SEQUENCING IN PROGRESS ***, 253 non-ordered parts. Homo sapiens, chromosome 5 clone CIT97dSKB_63A22, *** SEQUENCING IN PROGRESS ***, 253 unordered parts. Homo sapiens, chromosome 16 clone RPCI-11_498D10, *** SEQUENCING IN PROGRESS ***, 49 non-ordered parts. rxa00821 Homo sapiens, chromosome 6 clone RP1-32B1, *** SEQUENCING IN PROGRESS ***, in unordered parts. Homo sapiens, chromosome 6 clone RP1-32B1, *** SEQUENCING IN PROGRESS ***, in unordered parts. Homo sapiens PAC clone DJ0d95B23 of UL, complete sequence. rxa00827 T2367 MVAT4 bloodstream form of serodemo WRATatl.l Trypanosus to Rhodesian brucei, 5 'cDNA, mRNA sequence. Homo sapiens clone NH0576F01, complete sequence. vt53f08.rl Irradiated Mousehead Barstead MPLB7 Mus musculus, clone of AÜNc IMAGE: 1166823 5 ', mRNA sequence. rxa00842 human BAC clone GS165I04 of 7q21, complete sequence. Human BAC clone GS165I04 of 7q21, complete sequence. Caenorhabditis elegans, cosmid F02D8, complete sequence. rxa00847 Xenopus laevis rds / periphery (rds38) mRNA, complete cds. Homo sapiens chromosome 3q27 clone RPCI11-208N14, *** SEQUENCING IN PROGRESS ***, 51 non-ordered parts. Homo sapiens chromosome 3q27 clone RPCI11-208N14, *** SEQUENCING IN PROGRESS ***, 51 non-ordered parts. rxa00851 Homo sapiens chromosome 4, ** + SEQUENCING IN PROGRESS ***, 10 non-ordered parts. Homo sapiens chromosome 4, *** SEQUENCING IN PROGRESS ***, 10 non-ordered parts. Human DNA sequence of clone 824F16 on chromosome 20, complete sequence. rxa00852 Drosophila melanogaster chromosome 3 clone BACR22N13 (D1061) RPCI-98 22.N.13 map 96F-96F strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 83 non-ordered parts. Drosophila melanogaster chromosome 3 clone BACR22N13 (D1061) RPCI-98 22.N.13 map 96F-96F strain y; cn bw . 4. . t- ~,. . at .Mμafrm »sp, *** SEQUENCING IN PROGRESS ***, 83 non-ordered parts. Caenorhabditis elegans clone Y73B6x, *** SEQUENCING IN PROGRESS ***, 9 non-ordered parts. rxa00856 rxa00870 Streptomyces coelicolor semialdehyde gene dehydrogenase ethylmaloric acid (msdA), complete cds. Sequence 10 of patent US 5726299. Sequence 10 of patent US 5693731. rxa00875 Escherichia coli isopentyl diphosphate isomerase (idi) gene, complete cds. Escherichia coli, K-12 MG1655 sequester 262 of 400 of the complete genome. Escherichia coli K-12 genome; approximately 64 to 65 minutes. rxa00878 Drosophila melanogaster chromosome 2 clone BACR30D19 (D587) RPCI-98 30.D.19 map 49E-49F strain y; cn bw sp, *** SEQUENCING IN PROGRESS * + ", 79 non-ordered parts Drosophila melanogaster chromosome 2 clone BACR30D19 (D587) RPCI-98 30.D.19 map 49E-49? strain y; cn bw sp, ** * SEQUENCING IN PROGRESS * + *, 79 parts not ordered.

Caenorhabditis elegans clcr. Y51F8, *** SEQUENCING IN PROGRESS * t *, 30 non-ordered parts. rxa00880 ym54el2.rl brain of infant Soares 1NIB Homo sapiens cDNA clone IMAGE: 52158 5 ', sequence of MRNA. CITBI-E1-2578F1.TF CITBI-E1 Hemo sapiens genomic clone 2578F1, genomic research sequence. MRNA from human to KIAAC337 gene, complete cds. rxa00899 Neisseria gonorrhoeae pilS6 silent locus pilus. PSa plasmid (from Escherichia coli), 3 'end dehydropteroate synthase gene. Integron In7 (from pDGOlOO plasmid of Escherichia coli) genes of integrase (int), aminoglycoside adenylyltransferase (aad), resistance protein to quaternary ammonium compounds, dihydrofolate reductase (dhfrX), and dihydropteroate synthase (sull). rxa00902 HS_5404_B2_H05_T7A RPCI-11 Humar. Male BAC Library genomic clone of Homo sapiens plate = 980 col = 10 row = P, genomic research sequence. nbxb0007A07f CUGI Rice BAC Library genomic clone of Oryza sativa nbxb0007A07f, genomic research sequence.

P. sativum gene Psst70 for heat shock protein. rxa00931 F. rubripes GSS sequence, clone 145D10aA8, genomic research sequence. 5 F. rubripes GSS sequence, clone 069K22aG5, genomic research sequence. HS_2257_B1_B03_T7C CIT Approved Human Genomic Sperm Library D genomic clone of Homo sapiens plate = 2257 col = 5 row = D, genomic research sequence. rxa00941 Mycobacterium tuberculosis H37Rv complete genome; segment 85/162. Mycobacterium tuberculosis H37Rv complete genome; segment 85/162. 15 Mycobacterium tuberculosis protein gene for resistance to ethylmethane sulfonate (katG), 3 'end. rxa00962 Homo sapiens clone RP11-95I16, *** SEQUENCING IN PROGRESS ***, 17 non-ordered parts. 20 Gallus gallus anonymous sequence of cosmid mapping on chromosome 2 (cosmid 34 - contig 15), genomic research sequence. Homo sapiens clone RP11-95I16, *** SEQUENCING IN PROGRESS ***, 17 non-ordered parts. 25 rxa01060 Escherichia coli left end of the transposon Tn7 including integra of type 2. Caenorhabditis briggsae gene of CES-1 (ces-1), complete cds; and CPN-1 gene (cpn-1), partial cds. CIT- HSP-2381F4.TR CIT-HSP genomic clone of Home sapiens 2381F4, genomic research sequence. rxa01067 Mycobacterium leprae cosmid B1937. Synechocystis sp. groES and groEL genes. Synechocystis sp. PCC6803 complete genome, 7/27, 781449-920915. rxa01114 P. fragi genes faoA and faoB, complete cds. Pseudomonas sp. 61-3 genes for PhbR, acetoacetyl-CoA reductase, beta-quetothioiase and FHB synthase, complete cds. Streptomyces coelicolor cosmid 8D9. rxa01136 mx07a01.rl Soares NML mouse Mus musculus chlor. IMAGE: 679464 5 ', mRNA sequence. EST01834 ectoplacental mouse library from embryo of 7.5 dpc, Mus musculus, clone C0014F02 3 ', mRNA sequence. mx07a01.yl mouse Soares NML Mus musculus chlor. IMAGE: 679464 5 ', mRNA sequence. rxa01138 Xenopus laevis int-1 mRNA for int-1 protein. Homo sapiens Xq28 BAC RPCI11-382P7 (Roswell Park Cancer Institute Human BAC Library) complete sequence. Homo sapiens Xq28 BAC RPCI11-382P7 (Roewell Park Cancer Institute Human BAC Library) sequence • complete. 5 rxa01172 Streptomyces coelicolor cosmid E39. Mycobacterium smegmatis phage resistance gene (mpr), complete cds. Bacillus subtilis, genome, region trnl-feuABC. rxa01191 DNA sequence of human being from clone 10 1191B2 on chromosome 22ql3.2-13.3. It contains part of the BIK gene (NBK, BP4, BIP1) for killer cell that interacts with BCL2; apoptosis-inducing factor), a pseudogene of ritosomal protelin 40S S25 and part of a novel acyltransferase gene 15 alternately spliced similar to C. elegans C50D2.7 contains ESTs, STSs, GSSs, two putative CpG islands and genomic marker D22S1151, sequence • complete. Human DNA sequence from clone 20 1191B2 on chromosome 22ql3.2-13.3. Contains part of the BIK gene (NBK, BP4, BIP1) for killer cell that interacts with BCL2 (inducer of apoptosis), a pseudogene of ribosomal protoin 40S S25 and part of a novel acyltransferaea gene 25 alternately spliced similar to C. elegans C50D2.7 contains ESTs, STSs, GSSs, two putative CpG islands and genomic marker D22S1151, complete sequence. • rxa01205 Mycobacterium tuberculosis H37Rv complete genome; 5 segment 57/162. Arabidopsis thaliana DNA, 40 kb surrounding the ACS1 locus. Arabidopsis thaliana DNA, chromosome 4, BAC clone T6K21 (ESSA project). ^ k} 10 rxa01212 Streptomyces coelicolor cosmid D25. S. lividans gene of tRNA-GlyU beta. Streptomyces coelicolor cosmid H10. rxa01219 Sequence 19 of Patent WO9743409. Sequence 20 of Patent WO9743409. 15 Sequence 22 of Patent WO9743409. rxa01220 Human DNA sequence of clone 512B11 on chromosome 6p24-25. It contains the desmoplakin I (DPI) gene, ESTs, STSs and GSSs, complete sequence. zb76hll.sl Soares_senescent_fibroblasts_NbHSF cDNA 20 • from Homo sapiens clone IMAGE: 3C9573 3 'mRNA sequence. _ nk36c09.sl NC1_CGAP_GC2 Homo sapiens cDNA clone IMAGE: 1015600 3 ', similar to gb: X01677 GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE, LIVER 25 (HUMAN); mRNA sequence. rxa01221 Homo sapiens chromosome 16, map 16q23.3-q24.1 sequence. Equine herpesvirus 2, complete genome Escherichia coli K-12 MG1655 section 297 of 400 of the complete genome. rxa01222 Sequence 1 of the patent US 5854034. Sphingomonas S88, synthesis genes of sfinganpolysaccharide (spsG), (spsS), (spsR), glycosyltransferase (speQ), (spsl), glycosyltransferase (spsK), glycosyltransferase (spsL), (spsJ) ), (spsF), (spsL, (spsC), (spsE), Urf32, Urf26, ATP binding cassette transporter (atrD), cassette transporter binding with ATP (atrB), glucosyl-isoprenylphosphatransferase (spsB), glucose-1-phosphate thymidylyltransferase (rhsA), dTDP-6-deoxy? -D-glucose-3, 5-epimerase (rhsC), dTDP-D-glucose-4,6-dehydrate (rhsB), dTDP-6-deoxy -L-mannose-dehydrogenase (rhsD), Urf31, and Urf34, complete cds Babesia bovis protein binding RNA with ATP (babc), complete cds rxa01260 Corynebacterium glutamicum gene ipd, complete CDS Mycobacterium tuberculosis H37 ? v complete genome, segment 24/162. Homo sapiens chromosome 5, BAC clone 249h5 (LBNL 8M? H149), complete sequence. rxa01261 Corynebacterium glutamicum gene lpd, complete CDS. Drosophila melanogaster, chromosome 3L / 75A1 clone RPCI98-17C17, - ** SEQUENCING IN PROGRESS ***, 5 50 unordered parts. Drosophila melanogaster, chromosome 3L / 75A1 clone RPCI98-17C17, - ** SEQUENCING IN PROGRESS ***, 50 unordered parts. rxa01269 Bacteroides fragilis 638R polysaccharide B (PS B2) 10 loci of biosynthesis, complete sequence; and genes • unknown. Actinobacillus actinomycetemcomitans DNA for glycosyltransferase, lytic transglycosylase, dTDP-4-rhamnose reductase, complete cds. 15 Actinobacillus actinomycetemcomitans gene group for synthesis of 6-deoxy-L-talano, complete cds. rxa01291 Rattus norvegieus, clone OTSUKA, OT78.02 / 918b07, f microsatellite sequence, site focused on sequence. 20 Rattus norvegicus, clone OTSUKA, OT78.02 / 918b07, microsatellite sequence, site focused on sequence. Homo sapiens chromosome 4, *** SEQUENCING IN PROGRESS ***, ~ unordered parts. 25 rxa01292 Bacillus subtilis complete genome (section 17 of 21): from 3197001 to 3414420. Drosophila melanogaster chromosome 3 clone BACR4dJ06 (D1102) RPCI-98 48. J.6 map 96F-96F, strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 71 non-ordered parts. Drosophila melanogaster chromosome 3 clone BACR48J06 (D1102) RPCI-98 48. J.6 map 96F-96F, strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 71 non-ordered parts. rxa01293 CIT-HSP-2290D17. TF CIT-HSP genomic clone of Homo sapiens 2290D17, genomic research sequence. CIT- HSP-2290D17.TF CIT-HSP Hieron sapiens genomic hundred 2290D17, genomic research sequence. rxa01339 Magnaporthe grise gene for nitrogen regulatory protein (ÑUTÍ), complete cds. Homo sapiens chromosome 5 clone CIT9755KB_107C20, *** SEQUENCING IN PROGRESS '**, 31 unordered parts. Homo sapiens chromosome 5 clone CIT9755KB_107C20, *** SEQUENCING IN PROGRESS < ***, 31 non-ordered parts. rxa01382 Homo sapiens chromosome 19 clone CIT9 ~ 3SKB_83J4, *** SEQUENCING IN PROGRESS ***, 6 unordered parts. Homo sapiens chromosome 19 clone CIT978SKB_83J4, ** SEQUENCING IN PROGRESS »**, 6 parts not ordered. Chromosome X of human being, complete sequence. rxa01399 mo03b09.rl Stratagene mouse lung 937302 Mus musculus 7? DNc clone IMAGE: 552473 5 'similar to gb: L06505 06S PROTEIN PIBOS0MAL L12 (HUMAN); gb: L04280 ribosomal protein from Mus musculus (MOUSE); MRNA. pat.pk0074.e9. f cDNA of activated chicken T cells, cDNA of Gallus gallus clone pat .pk0074. e9. F 5 'similar to subunit 3 of H-ATPase, mRNA sequence. Gallus gallus, B subunit gene of H + ATPaea vacuolar, complete cds. rxa01420 Homo sapiens chromosome 4, *** SEQUENCING IN PROGRESS ***, 7 non-ordered parts. Homo sapiens chromosome 4, *** SEQUENCING IN PROGRESS ***, 7 non-ordered parts. Caenorhabditis elegans clone F41B4, ** t SEQUENCING IN PROGRESS ***, 1 part not ordered. rxa01467 Caenorhabditis elegans chromosome V clone Y102G3, ** 'SEQUENCING IN PROGRESS *** Caenorhabditis elegans chromosome V clone Y102G3, *** SEQUENCING IN PROGRESS *** Caenorhabditis elegans chromosome V clone Y102G3, *** SEQUENCING IN PROGRESS *** rxa01576 Aeromonas salmonicida genes of chaperonein GroES and chaperonin GroEL, complete cds. Aeromonas salmonicida genes of chaperonin GroES and chaperonin GroEL, complete cds. mgae0003aCllf Magnaporte grisea Appressorium Stage cDNA Library pyricularia cystoid grisea clone mgae0003aCllf 5 ', sequence of APNm. rxa015d0 RPCI-11-419F2. TV RPCI-11 genomic clone of Homo sapiens RPCI-11-419F2, genomic research sequence. Drosophila melanogaster, chromosome 2R region 44C4-44C5, Pl clone DS06765, complete sequence. Drosophila melanogaster, chromosome 2R region 44C4r 44C5, Pl clone DS06765, complete sequence. rxa01584 rxa01604 Homo sapiens chromosome 5 clone CIT-HSPC_327F10, + ** SECURE? CIAMIE? TO E? PROGRESS * ", 15 non-ordered parts Homo sapiens chromosome 5 clone CIT-HSPC_327F10, *** SECURE? CIAMIE? TO E? PROGRESS * - *, 15 non-ordered parts.

Homo sapiens chromosome 5 clone CIT975SKB_38B5, *** SEQUENCING IN PROGRESS ***, 7 non-ordered parts. • rxa01614 Corynebacterium glutamicum AND for L-malate: 5-quinone oxidoreductase. afr03g07.sl Soares_testis_NHT Homo sapiens cDNA clone IMAGE: 1030620 3 'similar to TR: G976083 G976083 RELATED TO HISTONE H2A; mRNA sequence. Homo sapiens PAC clone DJ1136G02 of 7q32-q34, 10 complete sequence. • rxa01629 C. glutamicum gene proP. C. glutamicum gene proP. Homo sapiens, chromosome 8, BAC 388036, complete sequence. 15 rxa01644 M. leprae sequence genomic DNA, cosmid b577. Mycobacterium leprae cosmid B24C7. Mycobacterium tuberculosis H37Rv ger.oma complete; segment 155/162. rxa01667 Corynebacterium glutamicum binding prctein gene 20 with ATP, thermal shock (clpB) cd = complete. Drosophila melanogaster, chromosome 3L / 77E1 clone RPCI98-13F11, *** SEQUENCING EIK PROGRESS ***, 70 unordered parts. Drosophila melanogaster, chromosome 3L.'77E1 clone 25 RPCI98-13F11, *** SEQUENCING IN PROGRESS ***, üHJ f ^ j 70 unordered parts. rxa01722 F. rubripes GSS sequence, clone 077P23aB10, jß ^ genomic research sequence. F. rubripes sequence of GS ?, clone 077P23aBll, 5 genomic research sequence. Caenorhabditis elegans cosmid: T26H2, complete sequence. rxa01727 Corynebacterium glutamicum, beta C-S lyase (aecD) genes and 10 branched chain amino acid uptake vehicle (bnrQ), complete cds, and hypothetical protein gene Yhbw (yhbw), partial cds. Homo sapiens clone RP11-7F18, SEQUENCE OF DRAFT WORK, 19 non-order parts. Homo sapiens clone RP11-7F18, WORK DRAFT SEQUENCE 15, 19 non-order parts. rxa01737 Streptomyces coelicolor cosmid 3D3. Homo sapiens chromosome 14 clone P-976B16, *** f SEQUENCING IN PROGRESS ***, in ordered parts. 20 Homo sapiens chromosome 14 clone? -976316, *** SEQUENCING IN PROGRESS ** -, in ordered parts. (rxa01762 Mycobacterium tuberculosis H3 ~? v complete genome, segment 10/162, 25 Streptomyces coelicolor cosmid 5G10.

Streptomyces coelicolor cosmid E29. rxa0I764 S. pombe chromosome I cosmid c343. S. pombe chromosome I cosmid c343. rxa01801 687009D03.and 687 - early embryo of Delaware Zea mays cDNA, mRNA sequence. RPCI-11-248N4.TV RPCI-11 Homo sapiens genomic clone RPCI-11-248N4, genomic research sequence. RPCI-11-248N4.TV RPCI-I1 Homo sapiens genomic clone RPCI-11-248N4, genomic research sequence. rxa01823 Streptomyces coelicolor cosmid 151. Escherichia coli, genomic sequence from 9 to 12 minutes. Bacillus subtilis complete genome (section 18 of 21): from 3399551 to 3609360. rxa01853 Mycobacterium tuberculosis H37Rv complete genome; segment 114/162. Homo sapiens cion RPCI11-296K13, *** SEQUENCING IN PROGRESS ***, 8C unordered parts. Homo sapiens clone RPCI11-296K13, + ** SEQUENCING IN PROGRESS ***, 81 non-ordered parts. rxa01881 Homo sapiens chromosome 4 clone 173_C_09 map 4, *** SEQUENCING IN PROGRESS ***, 10 ordered parts.

Homo sapiens chromosome 4 clone 173_C_09 map 4, *** SEQUENCING IN PROGRESS ***, 10 ordered parts. Mycobacterium tuberculosis H37Rv complete genome; segment 61/162. rxa01d94 Mycobacterium tuberculosis H37Rv complete genome; segment 126/162. Caenorhabiditis elegans cosmid F46H5. Drosophila melanogaster chromosome 2 clone BACR03E19 (D1033) RPCI-98 03.E.19 map 36E-37C strain y; cn bw sp; *** SEQUENCING IN PROGRESS ***, 94 non-ordered parts. rxa01897 Caenorhabditis elegans chromosome II clone Y46B6, *** SEQUENCING IN PROGRESS ***, in unordered parts. Caenorhabditis elegans chromosome II clone Y48B6, *** SEQUENCE IN PROGRESS ***, in unordered parts. Caenorhabditis elegans chromosome II cion Y53F4, *** SEQUENCING IN PROGRESS "*, in unordered parts rxa01946 Mycobacterium tuberculosis H37Rv complete genome, segment 64/162, Streptomyces coelicolor cosmid 5F2A, S. capreolus gene ard 1. rxa019d0 Genomic sequence for Arabicopsis thaliana BAC F4N2 of chromosome I, complete sequence. Arabidopsis thaliana, genomic DNA, chromosome 5, • CT clone: K19E1, complete sequence. 5 Arabidopsis thaliana, DNA genémicc, chromosome 5, TAC clone: K19E1, complete sequence. rxa01983 Drosophila melanogaster chromoscma 2 clone BACR03L08 (D532, RPCI-98 03. L.8 map 40A-40C strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 9 parts 10 not ordered. Droscphila melanogaster chromoscma 2 clone BACR03L08 (D532 RPCI-98 03. L.8 map 40A-40C strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 9 non-golden parts 15 Droscphila melanogaster chromoscma 2 clone BACR03L08 ( D532 RPCI-98 03. L.8 map 40A-40C strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 9 parts • not ordered. rxa02020 C. glutamicum ORF3 and aroP gene. 20 Patent Sequence WO970163. "Salmcnella typhimurium transport protein, complete cds, and RNA-Arg transfer rxa02029 Homo sapiens chromosome 11 clone pDJ363p2, *** SEQUENCING IN PROGRESS - **, 22 parts no 25 ordered.

Homo sapiens chromosome 11 clone pDJ363p2, *** SEQUENCING IN PROGRESS ***, 22 parts nc ^^ ordered. Homo sapiens chromosome 6 clone RP1-118B18 map 5 p24.1-25.3, *** SEQUENCING IN PROGRESS * * *, in non-ordered parts. rxa02030 Homo sapiens 12q24 BAC RPCI11-124N23 (Roswell Park Cancer Institute Human BAC Library) complete sequence. 10 Homo sapiens BAC clone NH0436C12 of 2, complete sequence. Homo sapiens BAC clone NH0436C12 of 2, complete sequence. rxa02073 c. glutamicum GDHA gene. 15 Corynebacterium glutamicum, gdh gene for glutamate dehydrogenase. | Streptomyces coelicolor cosmid 2H4. • rxa02074 rxa02095 zjl2b06.sl Soares_fetal_liver_spleen_lNFLS_Sl Home 20 sapiens cDNA clone IMAGE: 450035 3 'similar to contain LTR5.t3 LTR5 repeating element; mRNA sequence. Homo sapiens chromosome 8 clone RP11-202I12 map 8, SAMPLE OF LOW PASSAGE SEQUENCE. 25 zd52c02.rl Soares fetal_heart NbHH19W Homo sapiens cDNA, clone IMAGE: 344258 5 'similar to contain LTR5.b2 LTR5 repeating element; mRNA sequence. rxa02099 Corynebacterium glutamicum genes amtP, glnB, glnD and 5 partial genes ftsY and srp. Homo sapiens chromosome 19 clone CITB-H1_2189E23, *** SEQUENCING IN PROGRESS ***, 35 non-ordered parts. Homo sapiens chromosome 19 clone CITB-H1_2189E23, * + * 10 SEQUENCING IN PROGRESS ***, 35 non-ordered parts. rxa02115 Homo sapiens clone GS502B02, *** SEQUENCE IENTO IN PROGRESS ***, 3 parts not ordered. Homo sapiens clone GS502B02, *** SEQUENCING IN 15 PROGRESS ***, 3 parts not ordered. Human mRNA for HM145. i rxa02128 Mycobacterium tuberculosis H37Pv complete genome; fl segment 98/162. Mycobacterium tuberculosis H37Rv complete genome; 20 segment 98/162. nbxb0006D03e CUGI Rice BAC Library Oryza sativa genomic clone nbxb0006D03r, genomic research sequence. rxa02133 Mycoplasma pneumoniae section 53 of 63 of the complete genome.

Drosophila melanogaster chromosome 3 clone BACR10M16 (D743) RPCI-98 10.M.16 map 93C-33D strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 186 unordered parts. Drosophila melanogaster chromosome 3 clone BACR10M16 (D743) RPCI-98 10.M.16 map 93C-93D strain y; cn bw sp, *** SEQUENCING IN PR0GP? 30 ***, 166 unordered parts. rxa02150 um06e09.yl mouse kidney Sugano mkia Mus musculus cDNA clone IMAGE: 2162312 5 'similar to SW: AMPL._BOVIN P00727 CIT0S0L AMINOPEPTIDASE; mRNA sequence, RPCI11-30D24. TP RPCI-11 Homo sapiens genomic clone RPCI-11-30D24, genomic research sequence. Homo sapiens clone NH0552E01, complete sequence. rxa02171 Rhodobacter capsulatus strain SB1C: 3, partial genome. EST216450 rat lung normalitadc, Bento Soares Rattus sp. CDNA clone RLUC075 extreme 3 ', mRNA sequence. P. vulgaris phytohemaglutmin gene encoding phytohemaglutinin erythroagglutin ante (PHA-E), complete cds. rxa02173 C. glutamicum gene glt for citrate synthase and ORF. C. glutamicum gene glt for citrate smtase and ORF. Rhizobium sp. NGR234 plasmid prGR234a, section 41 of 46 of the complete plasmid sequence. rxa02224 Corynebacterium striatum YbhB gene of hypothetical protein, partial cds; TetB genes of ABC transporter (tetB), of TetA de • ABC transporter (tetA), transposase, 23S 5 rRNA methyltransferase, and transposase, complete cds; and unknown genes. Homo sapiens chromosome 5 clone CIT-HSPC_248019, *** SEQUENCING IN PROGRESS ***, 2 ordered parts. 10 Homo sapiens chromosome 5 clone CIT-HSPC_248019, *** • SEQUENCING IN PROGRESC + **, 2 ordered parts. rxa02225 Mycoplasma pneumoniae section 53 of 63 of the complete genome. 15 tb96hll.xl NCI_CGAP_Col6 Homo sapiens cDNA clone IMAGE: 2062245 3 'similar to TP: Q15392 Q15392 ORF, COMPLETE CDS; rRNA sequence. • tb96hll.xl NCI_CGAP_Col6 Homo sapiens cDNA clone IMAGE: 2062245 3 'similar to T?: Q15392 Q15392 ORF, 20 COMPLETE CDS; RNAi sequence:. rxa02233 Erwinia carotovora pectma lyase gene (pnl), complete cds. AV021947 Mus musculus embryo ce 13 days, C57BL / 6J cDNA of Mus musculus clone 119CI24K23, sequence of 25 mRNA.

AV021947 Mus musculus 18-day embryo, C57BL / 6J CDNA of Mus musculus clone 1190024M23, mRNA sequence. rxa02253 mx79gl0.rl Mouse NML Soares cDNA from Mus musculus clone IMAGE: 692610 5 'similar to TR: E236517 E236517 F44G4.1; mRNA sequence. mx79gl0.rl NML mouse Soares cDNA from Mus musculus clone IMAGE: 692610 5 'similar to TR: E236517 E236517 F44G4.1; mRNA sequence. rxa02261 Corynebacterium glutamicum gene 3 'ppc, secG gene, amt gene, ocd gene and 5' soxA gene. C. glutamicum gen amt. C. glutamicum fesfoenolpyruvate carboxylase gene, complete cds. rxa02268 Neurospora crassa siderophore regulation protein gene (sre), complete cds. ud47a06.yl mouse mammary gland Soares NbMMG Mus musculus cDNA, clone IMAGE: 1449010 5 'similar to TR: 075585 075585 PROTEIN KINASE 2 ACTIVATED BY MITOGEN AND STRESS; mRNA sequence. Mus musculus Protein kinase-2 APNm activated by mitogen and stress (mMSK2), complete cds. rxa02269 HS_5462_B2_A04_T7A RPCI-11 Human Male BAC Library genomic clone of Homo sapiens, plate = 1058 col = 8 row = B, genomic research sequence.

M. H Homo sapiens chromosome 18 clone 53_I_0t map 18, *** SEQUENCING IN PROGRESS ***, 15 non-ordered parts. Homo sapiens chromosome 18 clone 53_I_06 map 18, *** 5 SEQUENCING IN PROGRESS ***, 15 non-ordered parts. rxa02309 Mycobacterium tuberculosis H37Rv complete genome; segment 28/162. Mycobacterium tuberculosis clone sequence y224. 10 Homo sapiens clone NH0091M05, *** SEQUENCING IN PROGRESS ***, 1 part not ordered. rxa02310 Mycobacteriurr. tuberculosis H37Rv complete genome; segment 28/162. Mycobacterium tuberculosis sequence and clone y224. 15 Human DNA sequence of PAC 279N11 on chromosome Xqll.2-13.3. rxa02321 Corynebacterium glutamicum genes dtsRl and dtsR2, cds fl complete. Brevibacterium lactofermentum genes dt = R and dtsR2. 20 Corynebacterium glutamicum gene dtsR, complete cds. rxa02335 Corynebacterium glutamicum thiosulfate sulfurtransferase gene (thtR), cds parciai, acyl CoA carboxylase gene (accBC), complete cds. Mycobacterium leprae cosmid B1308. 25 Mycobacterium tuberculosis H37Rv complete genome; segment 141/162. rxa02364 Pyrococcus horikoshii 0T3 Genomic DNA, 1166001- 1465000 nt. position (6/7). Pyrococcus horikoshii 0T3 Genomic DNA, 1166001- 1465000 nt. position (6/7). rxa02372 Homo sapiens chromosome 19 clone CIT-HSPC_429L19, *** SEQUENCING IN PROGRESS ***, 4 ordered parts. Homo sapiens chromosome 19 clone CIT-HSPC_429L19, *** SEQUENCING IN PROGRESS ***, 4 ordered parts. ot36c01.sl Soares_testis_NHT DNA clone of Homo sapiens IMAGE: 1618848 3 ', sequence of APNm. rxa02397 Arabidopsis thaliana chromosome 1 clone T1? 6, *** SECUE? CIAMIE? TO E? PROGRESS ***, 2 ordered parts. Arabidopsis thaliana chromosome 1 clone T1? 6, *** SECURE? CIAMIE? TO E? PROGRESS ***, 2 ordered parts. E. coli AD? genomic, clone Kohara # 335 (40.9-41.3 min). rxa02424 EST38262 embryo, 9 weeks Homo sapiens, AD? c end 5 ', sequence of AR? m. Homo sapiens chromosome 17, clone hRPK.214_0_1, complete sequence.

Homo sapiens chromosome 17, clone hRPK.21 _0_l, complete sequence. rxa02426 B. stearothermophilus gen lct. B. Stearothermophilus recombinant lct gene. B. stearothermophilus gene lct that encodes L-lactate dehydrogenase, complete cds. rxa02487 Streptomyces hygroscopicus putative pteridin-dependent dioxygenase, PKS 1,2,3 and 4 modules, and putative regulatory protein genes, complete cds and putative hydroxylase gene, partial cds. Mycobacterium tuberculosis H37Rv complete genome; segment 52/162. Pseudomonas abietaniphila BKME-9 genes of Ditl (ditl), small subunit of dioxygenase component DitA oxygenase (ditA2), large subunit of dioxygenase component DitA oxygenase (ditAl), DitH (ditH), DitG (ditG), DitF (ditF), DitR (ditR), DitE (ditE), DitD (ditD), aromatic diterpenoid extradiol ring dissociation diogenase (ditC), DitB (ditB), and dioxygenase ferredoxin component DitA (ditA3), complete cds; and unknown genes. rxa02511 Homo sapiens chromosome 22qll.2 BAC clone b 135h6 in region BCRL2-GGT, complete sequence.

Homo sapiens chromosome 22qll.2 PAC clone p_n5 in region BCRL2-GGT, complete sequence. wf24b07.xl Soares_NFL_T_GBC_Sl Homo sapiens cDNA clone IMAGE: 2356501 3 'similar to SW: PLZF_HUMAN Q05516 ZINC PLZF FINGER PROTEIN; mRNA sequence. rxa02512 Mycobacterium tuberculosis H37Rv complete genome; segment 117/162. Mycobacterium leprae cosmid L581. Gallus gallus .ARNm of tropomyosin receptor A (ctrkA), complete cds. rxa02527 Bacillus subtilis, genomic region rrnB-dnaB. Bacillus subtilis, genomic region rrnB-dnaB. Arabidopsis thaliana clone F23B24, *** SEQUENCING IN PROGRESS ***, 6 unordered parts. rxa02547 Citrullus lanatus gen Sat for serine acetyltransferase, complete cds and 5 'flank region. Citrullus vulgaris Serine acetyltransferase DNA (Sat), complete cds. Citrullus (lanatus gene of Sat for serine acetyltransferase, complete cds and flank region 5 '. Rxa02566 BNLGHÍ7498 six day cotton fiber Gossypium ^ ^ aítáfe &hirsutum, protein-like cDNA 50 (AB020715) KIAA0908 [Homo sapiens], mRNA sequence. C. glutamicum, putP gene. S. pombe chromosome I cosmid cl3G6. rxa02571 Corynebacterium glutamicum gene for multiple drug resistance protein (cmr), complete cds. wl55e03.xl NCl_CGAP_Bnr25 Homo sapiens cDNA clone IMAGE: 2428828 3 ', mRNA sequence. Corynebacterium glutamicum multiple drug resistance protein gene (cmr), complete cds. rxa02578 Arabidopsis thaliana genomic DNA, chromosome 5, CT clone: K16L22, complete sequence. Arabidopsis thaliana genomic DNA, chromosome 5, BAC clone: F14A1, complete sequence. Caenorhabditis elegans cosmid F36H9. rxa025dl Mycobacterium tuberculosis H37Rv, complete genome; segment 51/162. Mycobacterium tuberculosis H37Rv, complete genome; segment 51/162. rxa02582 Mycobacterium tuberculosis H37Rv, complete genome; segment 157/162. Mycobacterium tuberculosis H37Rv, complete genome; segment 127/162.

S. erythraea eryA gene for 6-deoxyerythronolide 3 synthase II and III. rxa02583 Streptomyces coelicolor subunit gene B ce propionyl-CoA carboxylase complex (pccB), is complete. Streptomyces coelicolor cosmid 1C2. Corynebacterium glutamicum genes dtsRl and dtsR2, ees complete. rxa02599 Ralstonia eutropha genes mmlH, m ll and mmlj. MBAFCW1C08T3 Brugia malayi Adult female cDNA (SAW96MLW-BmAF) Brugia malayi cDNA clone AFCW1CCS 5 ', mRNA sequence. Ralstonia eutropha genes mmlH, rrmll and mmlj. rxa02634 Synechocystis genes ndhC, psbG for? DH-C, PSII-G and 0RF157. HS_2265_A1_E11_MF CIT Approved Human Genomic Sperm Library D genomic clone of Homo sapiens plate = 2265 col = 21 row = 1, genomic research sequence. Melarhaphe neritoides partial cAM gene, exons 1-2. rxa0263d Thermotoga maritime section 68 of 136 of the complete genome. CITBI-E1-2575E20.TF CITBI-E1 genomic clone of Homo sapiens 2575E20, genomic research sequence.

? L *. J. J.,. JL i Caenorhabditis elegans clor. Y43H11, *** SEQUENCING IN PROGRESS "*, 7 non-ordered parts rxa02659 sc04a02.yl Gm-cl012 Glycine max cDNA GENOMIC SYSTEMS clone ID: Gm-cl012-1155 5 'similar to SW: PRS6_SOLTU P54778 26S SUBUNIDAD HOMOLOGO 6B PROTEASA REGULATOR; mRNA sequence. RPCI11-122K17.TJ RPCI-11 Homo sapiens genomic clone RPCI-11-122K17, genomic research sequence. sb95cll.yl Gm-cl012 Glycine max cDNA clone CLON ID SYSTEM: Gm-cl012-429 5 'similar to SW: PRS6_SOLTU P54778 26S SUBUNIDAD HOMOLOGO 6B PROTEASA REGULATOR; mRNA sequence. rxa02676 Caenorhabditis elegans cosmid B 213. Thaliana Arabidposis genomic research sequence from SP6 end of BAC F10D11 from the IGF library of Columbia strain of Arabidopsis thaliana, genomic research sequence. Rat ITPR2 gene for inositol triphosphate receptor type 2. rxa02677 Mus musculus, mRNA for LOK, complete cde. CIT- HSP-2346014.TR CIT-HSP Ho or sapiens genomic clone 2346014, genomic research sequence.

HS_5230_B1_G06_SP6E RPCI-11 Human Male BAC Library genomic clone of Homo sapiens plate = 806 col = 11 row = N, genomic research sequence. rxa02691 Drosophila melanogaster retroactively Idefix: genes 5 gag, pol and env, partial. Homo sapiens 12ql3.1 PAC RPCI1-228P16 (Roswell Park Cancer Institute Human PAC Library) complete sequence. Homo sapiens 12ql3.1 PAC RPCI1-228P16 (Roswell Park 10 Cancer Institute Human PAC Library) sequence • complete. rxa02718 AV132028 Mus musculus C57BL / 6J 11-day embryo Mus musculus clone cDNA 2700087FC1, mRNA sequence. 15 CIT-HSP-2385D24.TFB.1 CIT-HSP Homo sapiens genomic clone 2385D24, genomic research sequence. f CIT-HSP-2385D24.TFB.1 CIT-HSP Homo sapiens genomic clone 2385D24, genomic research sequence. rxa02749 Zymomonas mobilis strain ZM4 clone 67E10 genes of small subunit of carbamoylphosphate synthetase (carA), large subunit of carbamoylphosphate synthetase (carB), elongation factor of 25 transcription (greA), enolase (ene), alpha subunit of pyruvate deenidrcgenase (pdhA), beta subunit of pyruvate dehydrogenase (pdhB), of ribonuclease H (rnn), of homoserinaquinasa homolog, of alcohol dehydrogenase II (Adv.), and of subunit A of excinucleasa ABC (uvrA), complete cds; and unknown genes. Synechocystis sp. PCC6803 complete gencma, 19/27, 2392729-2538999. Chlamydia trachomatis section 23 of 87 of the complete genome. rxa02767 Corynebacterium glutamicum, cystathionine gamma-synthase gene (metB), complete cds. Streptomyces coelicolor cosmid 15. Human DNA sequence of clone 90L6 on chromosome 22qll.21-11.23. Contains an RPL15 pseudogene (ribosomal protein 60S L15),? STs, STSs, and GSSs, complete sequence. rxa02792 Streptomyces coelicolor strain A3 (2) integrase genes (int), superoxide dismutase II containing Fe (sodF2), permease Fe (ftrE) absorption system, and integral membrane protein Fe absorption system ( ftrD), complete cds. Escherichia coli, K-12 chromosomal region of 92. 8 a.m. 1 minutes Homo sapiens chromosome 5 tion CIT-HSPC_462NI9, *** SEQUENCING IN PROGRESS ***, 69 non-ordered parts. • rxa02794 Homo sapiens clone DJ0622E21, complete sequence. 5 Homo sapiens clone DJ0820A21, complete sequence. Human DNA sequence of clone 73H14 on chromosome Xq26.3-28, complete sequence. rxa02809 Serine protease gene mouse specific for cytotoxic T lymphocyte CCPII, complete sequence. 10 Serum esterase mouse granzyme C mouse, complete cds. Rattus norvegicus AR? M protease 4 natural killer cells (R? KP-4), complete cde. rxa02811 HS_5261_A2_E10_SP6E RPCI-11 Human Male BAC Library 15 genomic clone of Homo sapiens plate = 837 ccl = 20 row = I, genomic research sequence. HS_3248_A2_F02_T7C CIT Approved Human Genomic Sperm fl Library D Genomic clone of Homo sapiens plate = 3248 col = 40 row = K, genomic research sequence. CITBI-E1-2589G6.TF CITBI-E1 genomic clone of Homo sapiens 2589G6, genomic research sequence. rxa02836 GM08392.5 'GM ovary from Drosophila melanogaster 25 BlueScript AD? c from Drosophila meianogaster one hundred GM08392 5', mRNA sequence. GM06392.5 'GM Ovary of Drosophila melanogaster BlueScript AD? C from Drosophila melanogaster clone • GM08392 5 ', sequence of AR? M. 5 rxa03212 C. glutamicum betP gene. Streptomyces coelicolor cosmid 5F2A. Bacillus subtilis genomic region rrnB-dnaB. rxa03220 C.kessleri APNm of HUP2. UI-M-BHl-alq-h-05-O-UI.sl? IH_EMAP_M_SS Mus 10 musculus AD? Cl clone UI-M-BHl-alq-h-05-C-UI 3 ', • mRNA sequence. C. kessleri AR? M of HUP2. ID # Source of results% c homology Date of de Genbank (GAP) deposit 15 rxa00051 Homo sapiens 34,24"29-09-99 Homo sapiens 34,24" 29-09-99 Homo sapiens 35,033 09-12-99 f rxa00091 Bacillus subtilis 54,452 10-02-99 Streptomyces coelicolor 3 366,, 880066 16-08-99 20 A3 (2) Escherichia coli 38,642 17-04-96 rxa00092 Streptomyces coelicolor 49,934 04-06-9,9 Homo sapiens 37,11" 13-12-99 Homo sapiens 37,11"13-12-99 25 rxa00104 Mycobacterium 36,732 10-02-99 . * »- To tuberculosis Arabidopsis thaliana 37,150 03-0d-98 Mycobacterium 42,374 10-02-99 tuberculosis rxa00113 Corynebacterium 66,381 03-10-96 ammoniagenes Corynebacterium 57,259 14-10-97 ammoniagenes Mycobacterium 39,870 17-06-98 tuberculosis rxa00164 Homo sapiens 35,714 03-12-99 Homo sapiens 35,714 03-12-99 Homo sapiens 35,334 03-12-99 rxa00181 Corynebacterium 100,000 08-09-97 glutamicum Haemophilus influenzae 36,347 29-05-98 Rd Corynebacterium 37,454 08-09-97 glutamicum rxa00186 Homo sapiens 37,315 05-11-98 Homo sapiens 38,129 03-12-99 Homo sapiens 38,129; 03-12-99 rxa00187 Homo sapiens 37,297 01-11-98 Drosophila melanogaster 34,120 03-06-99 Homo sapiens 39,655 01-11-98 rxa00201 Homo sapiens 34,520 23-11-99 Rhodobacter capsulatus 38,163 06-01-96 Mus musculus 38,389 01-07-99 rxa00228 Homo sapiens 37,500 06-03-98 Homo sapiens 38,316 06-03-98 rxa00243 Homo sapiens 37,301 29-09-99 Homo sapiens 38,340 06-10-99 Homo sapiens 38,340 06-10-99 rxa00259 Caenorhabditis elegans 36,776 06-09-99 Caenorhabditis elegans 36,776 06-09-99 Saccharomyces 39,260 05-03-98 cerevisiae rxa00269 Homo sapiens 37,358 29-10-99 Homo sapiens 37,358 29-10-99 Bacillus halodurans 44,622 14-04-99 rxa00281 Streptomyces coelicolor 36,328 11-03-99 Streptomyces coelicolor 39,089 14-09-96 Homo sapiens 38,658 14-10-99 rxa00298 Corynebacterium 101,000 20-11-98 glutamicum Corynebacterium 101,000 20-11-98 glutamicum Rattus sp. 46,552 31-01-99 xa00346 Streptomyces coelicolcr 43,267 28-01-98 Streptomyces coelicolor 44,613 27-04-99 Escherichia coli 39,490 21-09-96 rxa00368 Bradyrhizcbium 40,409 27-10-99 japonicum Aeromonas sp. 10S-24 38,577 13-02-99 Homo sapiens 41,613 29-08-95 rxa00369 Yersinia pestis 35,396 04-01-99 Rhodobacter 54,800 04-06-98 sphaeroides Homo sapiens 45,786 12-06-98 rxa00410 Agrobacterium 46,490 10-10-94 tumefaciens Methanococeus 45,677 28-01-98 jannaschii 45,677 28-01-98 Plasmid p TiA6 46, 490 24-04-96 rxa00419 Mycobacterium 57,029 12-05-97 smegmatis Drosophila melanogaster 37,696 16-03-99 Drosophila melanogaster 39,607 06-10-99 rxa00432 Bacillus subtilis 49,810 26-11-97 Candida aíbicans 35,041 35-11-98 Homo sapiens 39,733 21-04-97 rxa00449 Drosophila melanogaster 38,392 02-08-99 Drosophila melanogaster 38,392 02-08-99 Rattus sp. 40,678 27-04-93 rxa00456 Fugu rubripes 47,407 25-06-98 Homo sapiens 38,406 03-08-99 Homo sapiens 36,951 11-05-99 rxa00477 Homo sapiens 41, 91 09-12-97 Homo sapiens 38,182 24-01-96 Homo sapiens 35,417 27-04-99 rxa00478 Homo sapiens 38,769 03-08-99 Homo sapiens 38,769 03-08-99 Homo sapiens 36,797 03-08-99 rxa00480 Homo sapiens 38,138 23-11-99 Homo sapiens 38,138 23-11-99 Mus musculus 38,712 01-12-98 rxa00524 Streptomyces coelicolor 4C, 234 16-08-99 A3 (2) Yersinia enterocolitica 55,634 20-10-99 Burkholderia sp. 4C, 793 13-07-99 rxa00526 Bacillus subtilis 54,534 26-11-97 Bacillus subtilis 54,534 01-07-98 Escherichia coli 51,481 07-02-99 rxa00559 Corynebacterium 39, 07 01-01-98 ammoniagenes Rattus sp. 39,267 02-04-98 Archaeglobus fulgidus 36,338 15-12-97 rxa00570 Homo sapiens 38,767 23-03-99 Mus musculus 37,900 11-03-99 Mus musculus 42,647 24-12-97 rxa00571 Mycobacterium 36,468 17-06-98 tuberculosis Homo sapiens 36,911 06-10-98 Homo sapiens 36,911 30-07-96 rxa00590 Homo sapiens 37,242 30-11-99 Homo sapiens 36,485 30-11-99 Mycobacterium leprae 39,272 15-06-96 rxa00591 Caenorhabditis elegans 34,092 02-09-99 Homo sapiens 36,310 09-04-99 Homo sapiens 36,617 04-02-99 rxa00596 Homo sapiens 34,321 02-05-98 Homo sapiens 35, ^ 39 02-05-98 Homo sapiens 40,404 06-02-99 rxa00607 Mycobacterium 40,562 23-06-99 tuberculosis Mycobacterium 38,833 23-06-99 tuberculosis rxa00623 Mycobacterium 60,552 17-06-98 tuberculosis Rhizobium sp. 51,992 08-08-96 Rhizobium sp. NGR234 51,992 12-12-97 rxa00681 rxa00690 Drosophila melanogaster 35,341 15-11-99 Homo sapiens 37,984 19-10-99 Homo sapiens 37,984 19-10-99 rxa00733 Dictyostelium discoideum 43, 265 28-04-99 Dictyostelium discoideum 43, 265 28 -04-99 rxa00735 Mycobacterium 36,819 17- 06--98 • tuberculosis Synechocystis sp. 52,585 07- 02--99 Synechocystis sp. 39,399 07- 02--99 rxa00796 Medicago truncatula 37,153 27- 09--99 Homo sapiens 38,014 30- 06--99 Homo sapiens 42,731 16- 10-97 10 rxa00301 Mycobacterium 59,350 17- 06-98 tuberculosis Mus musculus 39,398 09- 09-97 Mycobacterium 36,842 17-06--98 tuberculosis 15 rxa00802 Homo sapiens 37, 649 29-05--99 Dichelobacter nodosus 41,140 26-34-- 93 Arabidopsis thaiiana 36,946 21- 11--97 • rxa00819 Homo sapiens 38,270 03- 38--99 Homo sapiens 38,270 03- 38--99 20 Homo sapiens 38,947 03-38-99 rxa00321 Homo sapiens 36,565 23- 11--99 Homo sapiens 36,565 23- 11--99 Homo sapiens 34,346 19- 39--98 rxa00827 Trypanosoma brucei 40,000 12- 38--96 25 rhodesiense Homo sapiens 3 - ,, 903 28-09-99 Mus musculus 41, .562 24-11-97 rxa00842 Homo sapiens 36,, 321 23-07-97 Homo sapiens 37,, 284 23-07-97 Caenorhabditis 38 ,,, 163 23-11-98 rxa00847 Xenopus laevis 36,, 044 30-07-97 Homo sapiens 33,, 742 21-10-99 Homo sapiens 33, .742 21-10-99 rxa00851 Homo sapiens 39,, 833 09 -07-98 Homo sapiens 39, .833 09-07-98 Homo sapiens 39, .833 23-11-99 rxa00852 Drosophila mei, anogaster 36, .855 24-09-99 Drosophila mei, anogaster 36, .855 24- 09-99 Caenorhabditis elegans 36, 768 24-09-99 rxa00856 rxa00870 Streptomyces coelicolor 63 743 09-05-96 Unknown 33 850 01-12-98 Unknown 38 850 03-04-98 rxa00875 Escherichia coli 54 827 22-04-99 Escherichia coli 51 416 12-11-98 Escherichia coli 51 416 05-12-95 rxa00878 Drosophila melanogaster 36 592 02-08-99 Drosophila melanogaster 36 592 02-08-99 Caenorhabditis elegans 36 699 25-02-99 rxa00880 Homo sapiens 37 179 06-07-95 Homo sapiens 38,447 24-03-99 Homo sapiens 35,799 13-02-99 rxa00899 Neis Serum gonorrhoeae 40,623 20-07-96 Plasmid pSa 36,966 20-03-96 Plasmid pDGOlOO 38,966 20-03-96 rxa00902 Homo sapiens 37,900 10-06-99 Oryza sativa 41,885 12-09-98 rxa00931 Pisum sativum 36,366 03-07-96 Fugu rubripes 37,815 10-12-97 Fugu rubripes 37,698 10-12-97 Homo sapiens 31,552 13-03-99 rxa00941 Mycobacterium 37,902 17-07-98 tuberculosis Mycobacterium 39,140 17-06-98 tuberculosis Mycobacterium 42,517 26-08-99 tuberculosis rxa00962 Homo ssapiens 39,497 08-12-99 Gallus gallus 37,970 25-08-98 Homo sapiens 38,226 08-12-99 rxa01060 Escherichia coli 38,822 04-11-97 Caenorhabditis briggsae 39,921 09-12-99 Homo sapiens 39,019 16-09-98 rxa01067 Mycobacterium leprae 58,303 01-03-94 Synechocystis sp. 34,593 03-02-99 Synechocystis sp. 34,593 07-02-99 rxa01114 Psseudomonas fragi 51,919 02-02-99 Pseudomonas sp. 61-3 50,573 26-12-95 • Streptomyces coelicolor 42,200 26-02-99 5 rxa01136 Mus musculus 39,050 10-03-9"Mus musculus 38,562 26-08-93 Mus musculus 33,136 02-02-99 rxa01138 Xenopus laevis 40.03d 31-03-95 Homo sapiens 37,996 01-04-99 10 Homo sapiens 36,053 01-04-99 rxa01172 Streptomyces coelicolor 62,357 31-03-99 Mycobacterium 37,853 01-02-9"'smegmatis Bacillus subtilis 53,807 06-02-99 15 rxa01191 Homo sapiens 38,366 23-11-99 Homo sapiens 39,595 23-11-99 rxa01205 Mycobacterium 57,762 17-06-93 • tuberculosis Arabidopsis thaliana 32,971 07-09-93 20 Arabidopsis thaliana 35,273 16-08-99 rxa01212 Streptomyces coelicolor 39,654 21-09-99 A3 (2) Streptomyces lividans 54,493 20-12-93 Streptomyces coelicolor 44,638 04-05-99 25 rxa01219 unidentified 42,553 05-05-99 unidentified 43,229 05-05-99 unidentified 38,342 05-05-99 rxa01220 Homo sapiens 35,478 23-11-99 • Homo sapiens 39,623 20-08-96 5 Homo sapiens 36,111 08-09-97 rxa01221 Homo sapiens 40,199 05-09-99 Equine herpesvirus 2 37,001 02-02-96 Escherichia coli 39,471 12-11-98 rxa01222 Unknown 40,574 29-09 -99 A 10 Sphingomonas sp. S86 40,574 16-05-96 Babesia bovis 39,22d 09-0d-97 rxa01260 Corynebacterium 99,923 01-02-99 glutamicum Mycobacterium 59,056 17-06-98 15 tuberculosis Homo sapiens 36,270 05-09-98 rxa01261 Caorynebacterium 100,000 01-02- 99 glutamicum Drosophila melanogaster 50,512 16-10-99 20 Drosophila melanogaster 50,512 16-10-99 rxa01269 Bacteroides fragilis 56,071 01-12-99 Actinobacillus 46,679 21-02-93 Actinomycetemcomitans 46,679 21-02-93 Actinobacillus 46,679 13-02-99 25 Actinomycetemcomitans * • "- * - ~>.» 11 ít í rxa01291 Rattus norvegicus 34,374 02-03-99 Rattus norvegicus 34,374 02-03-99 Homo sapiens 34,312 15-09-99 • rxa01292 Bacillus subtilis 37,502 26-11-97 5 Drosophila melanogaster 35,637 01-10-99 Drosophila melanogaster 35,637 01-10-99 rxa01293 Homo sapiens 42,121 26-06-98 Homo sapiens 40,323 26-06-98 rxa01339 Magnaporthe grísea 38, "37 3-07-96 10 Homo sapiens 39, "41 06-10-99 • Homo sapiens 39, "41 06-10-99 rxa01382 Homo sapiens 40,154 31-10-99 Homo sapiens 40,154 31-10-99 Homo sapiens 37,521 29-01-96 15 rxa01399 Mus musculus 40,525 15-02-97 Gallus gallus 37, "35 15-09-99 Gallus gallus 36,244 07-12-95 f rxa01420 Homo sapiens 37,464 11-04-99 Homo sapiens 37,464 11-04-99 20 Caenorhabditis elegans 37,436 23-02-99 rxa01467 Caenorhabditis elegans 35,437 03-12-98 Caenorhabditis elegans 35,437 03-12-98 Caenorhabditis elegans 35,437 12-01-99 rxa01576 Aeromonas salmonicida 41,516 02-04-98 25 Aeromonas salmonicida 38,171 02-04-98 Pyricularia grísea 40,072 09-12-99 rxa01580 Homo sapiens 36, 522 2d-05-99 Drosophila melanogaster 36, 609 23-12-98 • Drosophila melanogaster 33, 612 23-12-98 5 rxa01584 rxa01604 Homo sapiens 33, 68Í 06--10--99 Homo sapiens 33, 683 06--10--99 Homo sapiens 33, 683 06--10--99 rxa01614 Corynebacterium. 42,284 11--08--98 10 glutamicum Homo sapiens 40, 092 02--03--98 Homo sapiens 37,811 28--04--99 rxa01629 Corynebacterium. 100,013 17--11--98 glutamicum 15 Corynebacterium 100,013 17--11--98 glutamicum Homo sapiens 35, 612 11--10--99 • rxa01644 Mycobacterium ieprae 55, 6C4 14--06-96 Mycobacterium leprae 36,41c 27--08-99 20 Mycobacterium 55,844 24--06-99 tuberculosis rxa01667 Corynebacterium 100, C 13 13--03--97 glutamicum Drosophila melanogaster 33.2C? 16--10--99 2D Drosophila melanogaster 33, 2C? 16--10--99 rxa01722 Fugu rubripes 40,192 10-12-97 Fugu rubripes 35.5"6 10-12-97 Caenorhabditis elegans 34," 59 19-11-99 rxa01727 Corynebacterium 99,929 04-06-98 glutamicum Homo sapiens 36,903 30-11-99 Homo sapiens 35, 42 30-11-99 rxa01737 Streptomyces coelicolor 38,054 08-07-99 Homo sapiens 35,147 05-10-99 Homo sapiens 35,147 05-10-99 rxa01762 Mycobacterium 49,5 ~ 4 23- 06-96 tuberculosis Streptomyces coelicolor 44, 349 24-03-99 Streptomyces coelicolor 40,246 12-03-99 rxa01764 Schizosaccharomyces 37,084 06-09-99 puembe Schizosaccharomyces 34,390 06-09-99 Pombe rxa01801 Zea mays 46,108 12-10-99 Homo sapiens 32,300 24-04-99 Homo sapiens 36,111 24-04-99 rxa01823. Streptomyces coelicolor 35, "" 9 16-08-99 A3 (2) Escherichia coli 39,211 15-01-97 Bacillus subtilis 36,999 26-11-97 ^? teitótrf? * rxa01853 Mycobacterium 37,612 17-06-98 tuberculosis Homo sapiens 39,306 16-09-99 Homo sapiens 39,006 16-09-99 rxa01881 Homo sapiens 39,130 14-10-99 Homo sapiens 39,130 14-10-99 Mycobacterium 37,393 18 -06-98 rxa01894 Mycobacterium 37,229 19-06-98 tuberculosis Caenorhabditis elegans 38,525 29-11-96 Drosophila melanogaster 31,579 18-08-99 rxa01897 Caenorhabditis elegans 34,703 01-04-99 Caenorhabditis elegans 34,703 01-04-99 Caenorhabditis elegans 33,333 15 -10-99 rxa01946 Mycobacterium 65,560 17-06-98 tuberculosis Streptomyces coelicolor 50,648 24-05-99 Streptomyces coelicolor 44,973 23-08-95 rxa01980 Arabidopsis thaliana 35,310 21-08-99 Arabidopsis thaliana 35,505 20-11-99 Arabidopsis thaliana 39,973 20 -11-99 rxa01983 Drosophila melanogaster 36,672 27-10-99 Drosophila melanogaster 36, 672 27-10-99 Drosophila melanogaster 32,367 27-10-99 rxa02020 Corynebacterium 100,000 30-11-97 unidentified glutamicer 1C1,000 06-03-98 salmonella typhimurium 51,547 13- 03-96 rxa02029 Homo sapiens 35,320 21-10-97 Homo sapiens 35,820 21-10-97 Homo sapiens 34,355 03-12-99 rxa02030 Homo sapiens 38,681 01-09-99 Homo sapiens 35,445 22-10-99 Homo sapiens 35,968 22- 10-99 rxa02073 Corynebacterium 39,655 24-05-93 glutamicum Corynebacterium 44,444 30-07-99 glutamicum. Streptomyces coelicolor 33,452 19-10-99 A3 (2) rxa02074 rxa02095 Homo sapiens 36, 518 24-12-97 Homo sapiens 35,473 07-12-99 Homo sapiens 34,174 16-10-96 rxa02099 Corynebacterium 113,000 14-05-99 glutamicum Homo sapiens 32,423 07-10-99 Homo sapiens 33,423 07-10-99 rxa02115 Homo sapiens 36,717 13-11-99 Homo sapiens 36,092 13-11-99 Homo sapiens 39,171 03-02-99 rxa02128 Mycobacterium 38,632 17-06-98 tuberculosis Mycobacterium 35,746 17-06-96 Tuberculosis Oryza sativa 38,482 12-09-96 rxa02133 Mycoplasma 32,317 18-11-96 pneumoniae Drosophila melanogaster 34,579 20-10-99 10 Drosophila melano -gaster 34,579 20-10-99 rxa02150 Mus musculus 39,385 10-09-99 Homo sapiens 3", 629 9-04-99 Homo sapiens 36,901 14-01-99 rxa02171 Rhodobacter caps? Ilatus 53,714 12-05-98 15 Rattus sp. 44,186 20-01-99 Phaseolus vulgaris 39,103 27-04-93 rxa02173 Corynebacterium 44,118 17-02-95 glutamicum Corynebacterium 36,189 17-02-95 20 Glutamicum Rhizobium sp. NGR234 35,487 12-12-97 rxa02224 Corynebacterium 3", 264 09-04-99 striatum Homo sapiens 36,459 07-10-99 25 Homo sapiens 36,459 07-10-99 rxa02225 Mycoplasma 35,496 18--11--96 pneumoniae Homo sapiens 35,589 18--03--99 Homo sapiens 42,786 18--03--99 rxa02233 Erwinia carotovora 37,780 26--04--93 Mus musculus 39,423 28--08- -99 Mus musculus 47,410 25--06-99 rxa02253 Mus musculus 36,136 12--03-97 Mus musculus 36,202 12--03-97 10 rxa0226i Corynebacterium 100,000 07--01--99 • Corynebacterium glutamicum 100, OOC 29--05--96 Glutamicum Corynebacterium 100,001 15--12--95 15 Glutamicum rxa02268 Neurospora crassa 39.268 22--10--98 Mus musculus 41,523 10--05-99 • Mus musculus 33,347 24--10--98 rxa02269 Homo sapiens 3 ^, 703 16--07-99 20 Homo sapiens 37,006 13--08--99 Homo sapiens 37, 006 13--08--99 rxa02309 Mycobacterium 52,344 17--06-98 tuberculosis Mycobacterium 52,344 03--12--96 25 tuberculosis rr ií ?? iW > 'p¡iaMitote- "> ---, ^ -' > > Homo sapiens 37,263 23-C4-99 rxa02310 Mycobacterium 36,361 17-06-98 tuberculosis Mycobacterium 36,361 03-12-96 tuberculosis Homo sapiens 34,516 23-11 -99 rxa02321 orynebacteriu 99,030 19-10-98 glutamicum Corynebacterium 98,973 28-07-99 Glutamicum Corynebacterium 99,030 19-13-98 Glutamicum rxa02335 Corynebacterium 99,947 16-01-97 glutamicum Mycobacterium leprae 40,247 30-01-96 Mycobacterium 67,568 10-02- 99 tuberculosis rxa02364 Pyrococcus horikoshii 36,130 08-02-99 Pyrococcus horikoshii 34,543 08-02-99 rxa02372 Homo sapiens 36,138 07-10-99 Homo sapiens 36,138 07-10-99 Homo sapiens 41,219 03-C6-98 rxa02397 Arabidoposis thaliana 38,566 12- 10-99 Thaliana Arabidoposis 38,566 12-10-99 Escherichia coli 39,600 21-03-97 rxa02424 Homo sapiens 38,603 21--04-97 Homo sapiens 36, 111 14--08-98 Homo sapiens 33, 427 14-- 08--98 rxa02426 Bacillus 39, 936 29--07--93 stearothermophilus synthetic construct 40,042 17--02-97 Bacillus 40,338 26 --04--93 Stearothermophilus rxa02487 Streptomyces 43,298 13--01--98 hygroscopius Mycobacterium 44,352 17--07--98 Tuberculosis Pseudomonas 43, 611 28--04--99 Abietaniphila rxa02511 Homo sapiens 37,971 30--11-- 99 Homo sapiens 38,239 13--09--99 Homo sapiens 38,983 07--07-99 rxa02512 Mycobacterium 37,407 17--07-98 tuberculosis Mycobacterium leprae 43,193 24--07--97 Gallus gallus 38,789 18--02- -96 rxa02527 Baciilus subtilis 37,395 04--02-98 Bacillus subtilis 36,218 04--02-98 Arabidopsis thaliana 35.40"29--04-99 rxa02547 Citrullus lanatus 35,449 20--08-97 Citrullus lanatus 35,449 06-02-99 Citrullus lanatus 34,646 21-08-97 rxa02566 Gossypium hirsutum 35,099 11-07-99 Corynebacterium 38,562 08-09-97 Glutamicum Schizosaccharomyces 35,774 18-10-99 Pombe rxa02571 Corynebacterium 41,872 09-04-97 Glutamicum Homo sapiens 39,139 08-26-99 Corynebacterium 38,552 09-04-97 Glutamicum rxa02578 Arabidopsis thaliana 34,213 21-11-99 Arabidopsis thaliana 36,461 21-11-99 Caenorha bditis 35,977 08-08-97 rxa02581 Mycobacterium 38,517 17-07-98 tuberculosis Mycobacterium 39,173 17-07-98 tuberculosis rxa02582 Mycobacterium 38,548 24-07-99 tuberculosis Mycobacterium 46,263 l "> -07-98 tuberculosis Sccharopolyspora 45,053 23-02-92 erythraea rxa32583 Streptomyces coelicolor 58,397 08-12-99 Streptomyces coelicolcr 52,916 15-01-99 Corynebacterium 58,309 19-10-98 Glutamicum rxa02599 Ralstonia eutropha 35,264 22-01-98 Brugia malayi 42,377 08-07--97 Ralstonia eutropha 41,146 22-01--98 rxa02634 Synechocystis PCC6803 38,145 10-02--99 Homo sapiens 38,789 27-08--98 Melarhaphe neritoides 39,098 02-07--99 rxa02638 Maritime Thermotoga 0,104 02- 07--99 Homo sapiens 36, 451 23-03--99 Caenorhabditis elegans 3 399,, 007722 23-02--99 rxa02659 Glycine max 41,566 06-12--99 Homo sapiens 34,762 07-05--99 Glycine max 39,063 06-12--99 rxa02676 Caenorhabditis elegans 35,814 02-07--99 Arabidopsis thaliana 38,462 28-07--99 Rattus norvegicus 3", 543 21-10--91 rxa02677 Mus musculus 33,829 07-02-99 Homo sapiens 36,565 31-07--98 Homo sapiens 36,534 29-05--99 rxa02691 Drosophila melanogaster 3 366,, 552222 19-01--99 Homo sapiens 39,341 02-02--99 Homo sapiens 3", 037 02-02--99 rxa02718 Mus musculus 43,529 11-07 -99 Homo sapiens 40,044 30-09-93 Homo sapiens 38,869 22-12-93 rxa02749 Zymomonas mobilis 39,024 14-11-98 Synechocystis sp. 34,573 13-02-99 Chlamydia trachomatis 38,940 32-09-98 rxa02767 Corynebacterium 100,000 10-09-99 glutamicum Streptomyces coelicolor 37,486 16-07-99 Homo sapiens 34,149 23-11-99 rxa02792 Streptomyces coelicolor 36,721 01-07-99 Escherichia coli 38,787 17-04-96 Homo sapiens 43,577 36-10-99 rxa02794 Homo sapiens 37,298 29-07-99 Homo sapiens 36,638 17-07-99 Homo sapiens 39,726 23-11-99 rxa02809 Mus musculus 47,518 19-01-96 Mus musculus 44,939 12-07-93 Rattus norvegicus 41,554 31-07-96 rxa02811 Homo sapiens 35,610 27-08-99 Homo sapiens 38,956 33-08-99 Homo sapiens 34,761 23-04-99 rxa02836 Drosophila melanogaster 40,604 28-11-98 Drosophila melanogaster 38,281 28-11-98 rxa03212 Corynebacterium 99,931 08-09-97 glutamicum Streptomyces loelicolor 5", 557 24-05-99 A3 (2) • Bacillus subtilis 41,000 04-02-98 5 rxa03220 Chlorella kessleri 42,328 17-02-97 Mus musculus 41,758 18-09-99 Chlorella kessleri 35,106 17-02-97 EXAMPLES Example 1: preparation of total genomic DNA of 10 Corynebacterium glutamicum ATCC 13032 • A culture of Corynebacterium glutamicum (ATCC 13032) was grown overnight at a temperature of 30 ° C with vigorous agitation in BHI medium (Difco). The cells were harvested by centrifugation, the supernatant was discarded 15 and the cells were resuspended in 5 ml of buffer-I (5% of the original volume of the culture - all indicated volumes have been calculated for 1C1 ml of volume of ^ crop). Composition of buffer-I: 140.34 g / 1 of sucrose, 2.46 g / 1 of MgSOj x 7H: 0, 10 ml 1 of a solution of 20 KHPO4 (100 g / i, adjusted to pH 6.7 with KOH, 50 ml / l of M12 concentrate (10 g / 1 (NH.,) _ SO :, 1 c 1 NaCl, 2 g / l MgSO x 7H20, 0.2 g / 1 CaCl;, 0.5 g / 1 yeast extract (Difco), 10 ml / l mixture of minor elements (20C mg / l FeSO ^ x H20, 10 mg / l ZnS04 x 7H, 0.3 mg / l MnCl2 x 4H, 0.30 mg / i H3BO3 20 mg / l 25 C0CI2 x 6H20, 1 mg / l NiCl2 x 6H, 0.3 mg 1 NaMo04 x 2H20, 500 mg / l complexing agent (EDTA or critical acid), 100 ml / l of vitamin mixture (0.2 mg / l of biotin, 0.2 mg / l of folic acid, 20 mg / i of p-aminobenzoic acid, 20 mg / l of riboflavin, 40 mg / l of ca-pantothenate, 140 mg / l of nicotinic acid, 40 mg / l l of pyridoxol hydrochloride, 200 mg / l of myo-inositol). Lysozyme was added to the suspension at a concentration of 2.5 mg / ml. After an incubation of about 4 hours at a temperature of 37 ° C, the wall of the cells was degraded and the resulting protoplasts were harvested by centrifugation. The pellet was washed once with 5 ml of buffer-I and once with 5 ml of buffer-TE (Tris-HCL, 10 mM, EDTA 1 mM, pH 8). The pellet was resuspended in 4 ml of TE buffer and 0.5 ml of an SDS solution (10%) and 0.5 ml of a NaCl solution (5 M) were added. After adding proteinace K at a final concentration of 200 μg / ml, the suspension is incubated for approximately 18 hours at a temperature of 37 ° C. The DNA was purified by extraction with phenol, phenol-chloroform-alcoholisoamyl and chloroform-alcoholisoamyl using standard procedures. Then, the DNA was precipitated by addition of 1/50 volume of 3 M sodium acetate and 2 volumes of ethanol, followed by a 30 minute incubation at a temperature of -20 ° C and a 30 minute centrifugation at 12,000 rpm in a high speed centrifuge using an SS34 rotor (Sorvall). The DNA was dissolved in 1 ml of TE buffer containing 20 μg / ml RNaseA and dialyzed at a temperature of 4 ° C against 1000 ml of TE buffer for at least 3 minutes. • hours. During this period of time, the shock absorber was changed 3 times. To 0.4 ml aliquots of the dialysed DNA solution, 0.4 ml of 2M LiCl and 0.8 ml of ethanol were added. After an incubation period of 30 minutes at a temperature of -20 ° C, the DNA was collected per centrifugation (13,000 rpm, Biofuge Fresco, Heraeus, Hanau, Germany). The 10 DNA pellet was dissolved in TE buffer. He • DNA prepared by this procedure can be used for all purposes, including Southern staining or construction of genomic libraries. Example 2: Construction of genomic libraries in 15 Escherichia coli of Corynebacterium glutamicum ATCC13032 Using the DNA prepared in accordance with that described in Example 1, cosmid and pld libraries were constructed in accordance with known and well-established methods (see, for example, Sambrook, JJ, Et al. 20 (1989) "Molecular Cloning: A Laboratory Manual", Cold Spring Harbcr Laboratory Press, or Ausubel, F.M. et al. (1994) "Current Protocols in Molecular Biology", John Wiley & Sons). Any pld or cosmid can be used. Plds pBR322 (Sutcliffe, J.G. 25 (1979) Proc. Natl. Acad. Sci. USA, 75: 3737-3741); pACYC177 (Change &Cohen (1978) J. Bacteriol 134: 1141-1156), plds of the pBS series (pBSSK +, pBSSK- and others, Stratagene, LaJolla, United States) or Loristd (Gibson, Z. Z., Rosenthal A. and Waterson, RH (1987) Gene 53: 283-2861. Gene libraries specifically for use C. glutamicum can be constructed using the pld pSL109 (Lee, H.-S. and AJ Sinskey (1994) J. Microbiol Biotechnol 4: 256-263) Example 3: DNA sequencing and functional analysis per computation Genomic libraries according to the described example 2 were used for DNA sequencing in accordance with standard methods, particularly through the chain termination method employing AB137 sequencing machines (see, eg, Fieisehman, RD et al. (1995) "Whole-genome Random Sequencing and Assembly cf Haemophilus Influenzae Rd., Science, 269: 496-512) Sequencing primers with the following nucleotide sequences were assembled: 5'-GGAAACAGTATGACCATG-3 '(SEQ ID NO: 677) or 5'-GTAAAACGACGGCCAGT-3' (SEQ ID NO: 67d) Example 4: Mutagenesis in vivo The In vivo mutagenesis of Corynebacterium glutamicum can be effected by passage of plasmid DNA (or another vector) through E coli or other microorganisms (eg Bacillus spp, or yeasts such as Saccaharomyces cerevisiae) that are affected in terms of their ability to maintain the integrity of their genetic information. Typical mutant strains have mutations in the • genes for the DNA repair system (for example, 5 mutHLS, mutD, mutT, etc., for reference, see Rupp, WD (1996) DNA repair mechanisms, in: Escherichia coli and Salmonella, p.2227-2294, ASM: Washington.). Such figures are well known to people with ordinary knowledge of the subject. The use of such strains is illustrated, 10 as for example in Greener, A. and Callahan, M. (1994 • Strategies /: 32-34. Example 5: DNA transfer between? Scherichia coli and Corynebacterium glutamicum Various species of Corynebacterium and Brevibacterium contiener. 15 endogenous plasmids (such as pHM1519 or pBLI) that replicate autonomously (for a review see Martín, J.F. et ai. (1987) Biotechnology, 5: 13 ~ -146). Vectors of m type "shuttle" for Escherichia coli and Corynebacterium. glutamicum can be easily constructed using 20 standard vectors for E. coli (Sanbrook, J. et al. (1989), "Molecular Cloning: A Laboratory Manual", Cold Spring Harbcr Laboratory Press or Ausubel, FM et al. (1994) "Current Protocols in Molecular Biology" , Jchn Wiley &Sons) to which is added an origin of replication for 25 Corynebacterium glutamicum and a suitable marker of Corynebacterium glutamicum. Such sources of application are preferably taken from enzogenic plasmids isolated from Corynebacterium and Brevibacterium species. Particularly useful as transformation markers for these species are kanamycin resistance genes (such as transposon derivatives Tn5 or Tn903) or chloramphenicol (Wi r.acker, EL (1987) "From Genes to Clones-Introduction to Gene Technology , VCH, Weinheim) There are numerous examples in the literature of a construction of a wide variety of "shuttle" vectors that replicate in both E. coli and C. glutamicum, and that can be created for various purposes, including gene overexpression (for reference see, for example, Yoshihama, M. et al. (1985) J. Bacteriol 162: 591-597, Martin JF et al. (1987) Biotechnology, 5: 137-146 and Eik anns, BJ et al. (1991) Gene, 102: 93-98) Using standard methods, it is possible to clone a gene of interest in one of the "shuttle" tipc vectors described above and introduce said hydride vectors into strains of Corynebacterium glutamicum. the transformation of C. glutamicum can be achieved by protoplast transformation (Kastsumata, R. Et al. (1984) J. Bacteriol. 159306-311), electroporation (Liebl, E. et al. (1939) FEMS Microbiol. Letters, 53: 399-303) and in which case they use special vectors, also by conjugation, according to what is described in Schafer. A et al. (1990, J. Bactepol 172: 1663-1666). It is also possible to transfer the vectors of • shuttle type for C. glutamicum to E. coli through the 5 preparation of plasmid DNA from C. glutamicum (using standard methods well known in the art) and transforming it into E. coii this transformation step can be employed using standard methods, but it is advantageous to use a deficient E. coli strain in Mcr 10 as for example NM522 Gough & Murria (1983; J. Moi. Biol .. • 166: 1-19). Genes can be over-exposed in strains in C. glutamicum using plasmids comprising pCGl (US Patent No. 4,617,267) or fragments of the 15, and optionally the gene for kanamycin resistance of TN903 (Grindley, N. D. and Joyce, C.M. (1980) Proc. Nati, Acad. Sci. United States 77 (12): 7176-7180). In addition, genes can be overexpressed in strains of C. glutamicum using plasmid pSL109 (Lee, H.-S. 20 and A. J. Sinskey (1994) J. Microbiol. Biotechnol. 4: 256-263). Apart from the use of replicative plasmids, the overexpression of genes can also be achieved by integration into the genome. Genomic integration in C. glutamicum or other 25 species of Corynebacterium or Brevibacterium can be achieved through well-known methods such as homologous recombination with genomic region (s), restriction endonuclease-mediated integration (REMI) see, eg, German Patent 19823834), or through the use of transposons. It is also possible to modulate the activity of a gene of interest by modifying the regulatory regions (eg, a promoter, a repressor and / or an enhancer) by sequence mapping, insertion or removal using site-directed methods (homologous recombination) or methods based on random events (such transposon mutagenesis or REMI). Nucleic acid sequences that function as transcriptional terminators can also be inserted 3 'in relation to the coding region of one or more genes of the invention; such terminators are well known in the art and described, for example, in Winnacker, E.L. (1987) From Genes to Clonee-Introduction to Gene Technology. VHC: Weinheim. Example 6: Evaluation of Mutant Protein Expression Observations of the activity of a mutated protein in a host cell are based on the fact that the mutant protein is expressed similarly and er. a similar amount as the wild-type protein. A useful method to determine the level of transcription of the mutant gene (a rtMJU? ^ indicator of the amount of mRNA available for translation to the gene product) is to perform a Northern blot analysis (for reference, see, for example Ausubel et al. • al. (1988) Current Protocols in Molecular Biology, Wiley: New York), wherein an initiator designed to bind to the gene of interest is labeled with a detectable marker (usually radioactive or chemiluminent) in such a way that when the total RNA of a organism culture is extracted, the matter in gel, transferred to a stable matrix 10 and incubated with this probe, the binding and amount of binding of • the probe indicates the presence and also the amount of mRNA for this gene. This information is evidence of the degree of transcription of the mutant gene. The total cellular RNA can be prepared from Corynebacterium glutamicum by Various methods, all well known in the art, such as for example the method described in Bormann, E.R. et al. '1992) Mol. Microbiol. 6: 317-326. To evaluate the presence or relative amount of protein transferred from this AR? M, standard techniques such as As a Western blot analysis, they can be used (see, for example, Ausubel et al. (1988) Current Protocols in Molecular Biology, Wiley:? Ew York). In this process, total cellular proteins are extracted, separated by gel electrophoresis, transferred to a matrix as for example Nitrocellulose, incubated with a probe, such as an antibody, which binds specifically with the desired protein. This probe is usually labeled with a chemiluminium or calorimetric marker that can be easily detected. The presence and amount of marker observed indicates the presence or amount of the desired mutant protein present in the cell. Example 7: Cultivation of genetically modified Corynebacterium glutamicum - Genetically modified Corynebacteria culture media and conditions are grown in synthetic or natural culture media. Numerous different culture media for Corynebacteria are well known and readily available (Lieb et al (1989) Appl. Microbiol. Biotechnol., 32: 205-210; von der Osten et al. (1998) Biotechnology Letters, 11: 11- 16; German Patent 4,120,867; Liebl (1992) "The Genus Corynebacterium, in: The Procaryotes, Volume II, Balows, A. et al. Springer-Verlag Editions.) These media consist of one or more carbon sources, nitrogen sources. , inorganic salts, vitamins and minor elements.The preferred carbon sources are sugars, such as, for example, monoeaccharides, disaccharides or polysaccharides, eg, glucose, fructose, mannose, galactose, ribose, sorbose, rubulose, lactose, maltose, Sucrose, raffinose, starch or cellulose are very good sources of carbon, it is also possible to supply sugar to the media through complex compounds such as molasses or other sugar refining byproducts. as of different carbon sources. Other possible sources of carbon are alcohols and • Organic acids such as methanol, ethanol, acetic acid or 5-lactic acid. Sources of nitrogen are usually organic or inorganic nitrogen compounds or materials that contain these compounds. Exemplary sources of nitrogen include ammonia gas or ammonia salts such as NH4C1 or (NH) ¿S04, NH4OH, 10 nitrates, urea, amino acids or sources of • Complex nitrogen such as corn distillation liquor, soybean meal, soy protein, yeast extract, meat extract and others. Compounds of inorganic salts that can be included 15 in the media include the calcium, magnesium, sodium, cobalt, molybdenum, potassium, manganese, zinc and metal salts of chloride, phosphorous or sulfates. Chelation compounds can be adhered to a metal medium in solution. Chelation compounds in particular Useful agents include dihydroxyphenols, such as for example catechol or protocatequate, or organic acids such as citric acid. Typically, the media also contains other growth factors such as vitamins or growth promoters, examples of which include biotin, 25 riboflavin, thiamine, folic acid, nicotinic acid, pantothenate and pyridoxine. Growth factors and salts are frequently originated from components of complex media such as yeast extract, molasses, corn distillation liquor and others. The exact composition of the 5 compounds of the media depends strongly on the immediate experiment and is determined individually for each specific case. Information regarding media optimization is available in the book "Applied r; crobicl. Phy; iology, A Practica.1. ^ Rrar-r. Íe-iic? \ A ~, 10 P.M. Rodees, P.F. Stanbury, IRL Press (1997) pp. 53-73, ISBN 019 963577 3). It is also possible to select growth media from commercial suppliers, such as standard 1 (Merck) or BHI (infusion, DIFCO) or others. All medium components are sterilized, either 15 by application of heat (20 minutes at 1.5 bar and 121 ° C) or through sterile filtration. All the components can be sterilized either together or in case • necessary, separately. All medium components may be present at the beginning of growth, or 20 can be added optionally continuously or in batches. The culture conditions are defined separately for each experiment. The temperature must be within a range between 15 ° C and 45 ° C. the temperature can be 25 kept constant or it can be altered during the experiment. The pH of the medium should be within the range of 5 to 8.5, preferably about 7.0, and can be maintained by the addition of buffers to the medium. An exemplary buffer for that purpose is a potassium phosphate buffer. Synthetic shock absorbers such as MOPS, HEPES, ACES and others can be used alternatively or simultaneously. It is also possible to maintain a constant culture pH through the addition of NaOH or du "is growth." If one-or-one of mfdtd f? 10 complex such as yeast extract are used, the need for Additional buffers can be reduced due to the fact that many complex compounds have high buffering capacities.If a fermenter is used to grow the microorganisms, the pH can 15 also be controlled using gaseous ammonia. The incubation time is usually within a range of several hours to several days. This time is selected to allow the accumulation of the maximum amount of product in the broth. The growth experiments The disclosed can be made in various containers such as microtiter plates, glass tubes, glass jars, or glass or metal fermenters of different sizes. For the screening of a large number of clones, the micro organisms must be cultured in plates of 25 microtitre, glass tubes or shake flasks, with or without diverters. Preferably, 100 ml shake flasks filled with 10% (the volume) of the required culture medium are used. The bottles should be agitated on a rotary shaker (25 mm amplitude) using a 5 speed range of 100-300 rpm. Lost by evaporation can be reduced by maintaining a humid atmosphere; alternatively, a mathematical correction must be made to take into account the losses due to »vaporization. 10 If genetically modified clones are tested, an unmodified control clone or a control clone containing the basic plasmid without any insert should also be examined. The medium is inoculated at an OD5_c of 0.5 - 1.5 using cells grown on agar plates, for example CM plates. 15 (10 g / 1 glucose, 2.5 g / 1 NaCl, 2 g / 1 urea, 10 g / 1 polypeptone, 5 g / 1 yeast extract, 5 g / i e meat extract, 22 g / 1 NaCl, 2 g / 1 NaCl, 2 g / 1 urea, 10 g / 1 polypetone, 5 g / 1 yeast extract, 5 g / 1 meat extract, 22 g / 1 agar, pH 6.8 with 2M NaOH, which 20 have been incubated at a temperature of 30 ° C. the inoculation of the media is achieved through the introduction of a saline suspension of C. glutamicum cells from CM plates or the addition of a liquid precursor of this bacterium. 25 Example 8 - In vitro analysis of protein function aaaa, - > .¿.- .. mutants The determination of activities and kinetic parameters of enzymes is well established in the art. Experiments to determine the activity of a given altered enzyme should be adapted to the specific activity of the wild-type enzyme, which is within the ability of a person of ordinary skill in the art. General information about enzymes, as well as details *, r »pecífieos on structure, c: né't '.ct ,. principle * -, 10 methods, applications and examples to determine many enzymatic activities can be found, as for example, in the following references: Dixon, M., and Webb,? .C., (1979) Encimes, Longmans: London; Fersht, (1985)? Nzyme Structure and Mechanism. Freeman: New York; Walsh, '1979) 15 Enzymatic Reaction Mechanisms. Greeman: San Francisco; Price, N.C., Stevens, L. (1982) Fundamentals of Enzymology, Oxford Univ. Press: Oxford; Boyer, PD, edition (1983) The Enzymes, 3rd edition Academic Press: New York, Bisswanger, H., (1994) Enzymkinetik, 2nd edition VCH: Weinheim (ISBN 20 3527300325); Bergmeyer, HU, Berg eyer, J ., Graßl, M., editions (1983-1986) Methods of Enzymatic Analysis, 3rd edition volume I-XII, Verlag Chemie: Weinheim, and Ullmann's Encyclopedia of Industrial Chemistry (1987) vol.A9, "Enzymes". Weinheim, pages 352-363 25 The activity of proteins that bind with DNA can be measured .JHUSS ^ SSii by several well-established methods such as DNA band shift assays (also known as the gel delay test). The effect of such proteins on the expression of other molecules can be 5 measure using reporter gene assays (in accordance with the writing in Colmar, H. et al (1995) EMBO J. 14: 3895-3904 and references cited there). Reporter gene test systems are well known and established for C applications? "1 to prokaryotic cells, as in eukaryotic cells, using enzymes such as beta-galactosidase, green fluorescent protein and several others. The determination of membrane-transport protein activity can be carried out in accordance with techniques such 15 as described in Gennis, R.B. (1989) "Pores, Channels and Transporters", in Biomembranes, Molecular Structure and Function, Springer: Heidelberg, pages 85-137; 199-234; and 270-322. Example 9: Impact analysis of Mutant Protein on the The production of the desired product The effect of the genetic modification on C. glutamicum on the production of a desired compound (such as for example an amino acid) can be evaluated by culturing the typed microorganism under suitable conditions such 25 as described above) and analyzing the cell media and / or component for an increased production of the desired product (i.e., an amino acid). Such techniques of analysis are well known to a person with ordinary skill in the art and include 5 spectroscopy, thin layer chromatography, various types of staining methods, enzymatic and microbiological methods as well as analytical chromatography such as liquid chromatography. high performance (see, C > '^? by --jví-aplo Ull) acn, Encicl pedia cf "ndustrial 10 Chemistry, volume A2, pages 89-90 and pages 443-613, VCH: Weinheim (1985); Fallón, A. Et al. , (^ e "1)" Applications of HPLC in Biochemistry "in: Laboratory Techniques in Biochemistry and Molecular Biology, volume 17; REM et al. (1993) Biotechnology, volume 3, chapter III: "Product 15 recovery and purification ", pages 469-714, VCH: Weinheim, Beiter, PA et al. (1988) Bioseparations: downstream processing for biotechnology, John Wiley and Sons; Kennedy, JF and Cabral JMS (1992) Recovery processes fer biological materials , John Wiley and Sons; Shaeiwitz, JA and Henry, 20 J.D. (1988) Biochemical separations, in: Ulmann's Encyclopedia of Industrial Chemistry, volume B3, chapter II, pages 1-27, VCH: Weinheim; and Dechow, F.J. (1989) Separation and purification techniques in biotechnology, Noyes Publications). In addition to the measurement of the final fermentation product it is also possible to analyze other components of the metabolic pathways used for the production of the desired compound, such as intermediates and by-products, to determine the overall efficiency of the product. 5 production of the compound. Methods of analysis include measurements of nutrient levels in the medium (eg, sugars, hydrocarbons, nitrogen sources, phosphate, and other ions), measurements of biomass composition and recimi. The analysis provided: 1 of Wm 10 common biosynthetic pathways, and measurement of gases produced during fermentation Standard methods for these measurements are presented in Applied Microbial Physiology, A Practical Approach, P.M. Rhodes and P.F. Stanbury, eds. IRL Press, p. 103-129; 131-163; and 165-192 (ISBN: 0199635773) and 15 references mentioned there. Example 10: Purification of the desired product from culture C. glutamicum Recovery of the desired product from the cells of C. glutamicum or culture supernatant described above It can be effected through various methods well known in the art. If the desired product is not secreted from the cells, the cells can be harvested from the culture by low speed centrifugation, the cells can be used by standard techniques, such as 25 as mechanical force or sonication. The cell residue is removed by centrifugation, and the supernatant fraction containing the soluble proteins is conserved for < ^ additional purification of the desired compound. If the product is secreted from the cells of C. glutamicum, Then the cells are removed from the culture by low speed centrifugation, and the supernatant fraction is preserved for further purification. The fraction of supernatant from any of it, r > A methods or-purification is scmefd? '-ro ?? togr ^ f & with w? 10 a suitable resin, wherein the desired molecule is retained in a chromatography resin while many of the impurities in the sample are not, or where the impurities are retained by the resin while the sample is not. Such chromatography steps can be repeated 15 as necessary, using the same chromatography resin or different chromatography resins. A person with ordinary knowledge in the art is enabled to select appropriate chromatography resins and in their most efficient application for a particular molecule to 20 purify. The purified producer can be concentrated by filtration or ultrafiltration, and stored at a temperature at which the stability of the product is optimized. There is a wide range of purification methods known in the art and the preceding method of purification is not 25 limiting in any way. Such purification techniques are described, for example, in Bailey, J.E. & Ollis, D.F. Biochemicl Engineering Fundamentals, McGraw-Hill: New York (1986). The impurity identity of the isolated compounds can 5 be evaluated by standard techniques. These techniques include high performance liquid chromatography (HPLC), spectroscopic methods, staining methods, thin layer chromatography, NIRS, enzymatic assay, or in a simple manner. Such p «tn: f 10 Patek et al. (1994) Appl. Environ. Microbiol. 60: 133-140; Malakhova et al. (1996) Biotekhnologiya 11: 27-32; and Schmidt et al. (1998) Bioprocess Engineer. 19: 67-70. Ulmann's Encyclopedia of Industrial Chemistry, (1996) volume A27, VCH: Weinheim, pages 89-90, pages 521-540, pages 540-157 547, pages 559-566, 575-581 and pages 581-587: Michal, G. (1999) Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology, John Wiley and Sons; Fallón, A. et al. (1987) Applications of HPLC in Biochemistry in: Laboratory Techmques in Biochemistry and Molecular Biology, volume 17. Example 11: Analysis of gene sequences of the invention. The comparison of sequences and determination of percentage homology between two sequences are known techniques and 25 can be carried out using mathematical algorithm, as for example the algorithm of Karlin and Altschul (1990) Proc. Ntl. Acad. Sci. United States 87: 2264-68, modified in accordance with Karlin and Altschul (1993) Proc. Natl. Acad. • Sci. United States 90: 5873-77. Said algorithm is incorporated into the NBLAST and XBLAST programs (version 2.0) of Altschul, et al. (1990) J. Mol. Biol. 215: 403-10. BLAST nucleotide searches can be carried out with the NBLAST program, result = 100, word length = 12 to obtain sequences be -1? ~ Leb "r: o? - * 4ftoio? A" 10 with nucleic acid molecules of MCT of ia • invention Searches of proteins with BLAST can be carried out with the XBLAST program, result = 50, word length = 3 to obtain homologous amino acid sequences with MCT protein molecule 15 of the invention To obtain alignments with spaces for purposes of Comparison, Gapped BLAST can be used in accordance with the writing in Altschul et al., (1997) Nucleic Acids Res. 25 (17): 3339-3402 When using the BLAST and Gapped 3LAST programs, a 20 person with usual knowledge the subject will know how to optimize the parameters of the program (for example, XBLAST and NBLAST) for the specific sequence that is being done Another example of a mathematical algorithm used for the 25 com Paración of sequences is the algorithm of Meyers and Miller ^ M ^ Á. '. "E .; (1988) Comput. Appl. Biosci. 4: 11-17). This algorithm is incorporated into the ALIGN program (version 2.0), which is ? k part of the GCG sequence alignment programmatic package. When the ALIGN program is used 5 to compare amino acid sequences, a weight residue table PAM120, a space length penalty of 12, and a space penalty of 4 may be employed. Additional algorithms for sequence analysis are known in the c- > ic * and go -.] * 3y'en f) 10 ADVANCE and ADAM, in accordance with what is described in Torelli and Robotti (1994) Comput. Appl. Biosci. 10: 3-5; and FASTA, described in Pearson and Lipman (1988) P.N.A.S. 35: 2444-8. The percentage homology between two amino acid sequences 15 can also be achieved using a GAP program in the programmatic GCG package (available at http://www.gcg.com), using either a Blosum 62 matrix or a PAM 250 matrix and a space weight of 12, 10 8, 6 or 4 and a length weight of 2, 3 or 4. The percentage homology 20 between two nucleic acid sequences can be achieved using the GAP program in the programmatic GCG package, using standard parameters, such as a space weight of 50 and a length of 3.25 A comparative analysis of gene sequences of the invention with the present Genbank is carried out using known techniques (for example, Bexevanis and Ouellette, editions (1998) Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins, John Wiley and Sons: New York). The gene sequences of the invention were compared with genes present in Genbank in a 3 step process. In a first step, a BLASTN analysis was carried out (for example, an analysis of the invention for each nucleus of the invention) against the sequence of nucleotides present. in Genbank, and the top 500 results were retained for further analysis.A subsequent FASTA search (for example, a local alignment analysis and a combined global alignment analysis, where limited regions of the sequence were aligned) was performed on these 500 Each gene sequence of the invention was subsequently aligned globally with each of the three superior results according to FASTA, using the GAP program in the GCG programmatic package (using standard parameters.) In order to obtain correct results, the The length of the sequences extracted from Genbank was adjusted to the length of the search sequences by methods well known in the art.

Ai "are presented in Table 4. The resulting data are identical to the data that would have been obtained had a GAP (global) analysis been performed only on each of the genes of the invention compared to each 5 one of the references in Genbank, but it would have required a significantly reduced computation time compared to that analysis (global / GAP over the entire database.) Sequences of the invention for the ci it it does not: e obtain "i al? aeacf •;? 'ar:? b "i- * os ßk 10 cut-off values are indicated in Table 4 by the absence of alignment information A person with ordinary knowledge in the field will further understand that the percentages of GAP alignment homology presented in Table 4 ba or the heading "% homology (GAP!" 15 list in the European numeric format where a "," represents a decimal point. For example, a value of "40.345" in this column represents "40.345%". Example 12: Construction and Operation of DNA Microsets The sequences of the invention can be used 20 additionally in the construction and application of DNA microsets (the design, methodology, and uses of DNA sets are well known in the art and are described, for example, in Schena, M. et al. (1995) Science 270 : 467-470; Wodicka, L. et al., 1997) 25 Nature Biotechnology 15: 1359-1367; DeSaizieu, A. et al. ^ t i (1998) Nature Biotechnology 16: 45-48; and DeRisi, J.L. et al. (1997) Science 278: 680-686). Micro-sets of DNA are flexible solid supports consisting of nitrocellulose, nylon, glass, silicone, and other materials. Nucleic acid molecules can be joined on the surface in an orderly manner. After appropriate labeling, other nucleic acids and mixtures of nucleic acids can be hybridized onto the nucleic acid molecules "adas" and the marc Hr z, "titi liba" or to measure the individual signal strengths of the hybridized molecules. In defined regions, this methodology allows the simultaneous quantification of the relative or absolute quantity of all the nucleic acids or nucleic acids selected in the applied nucleic acid sample or mixture.The DNA microsets, therefore, allow an analysis of the expression of multiple (up to 6800 or more) nucleic acids in parallel (see, for example, Schena, M. (199) BioEssays 18 (5): 427-431). The sequences of the invention can be used to design oligonucleotide primers that can amplify defined regions of one or more genes of C. glutamicum by a nucleic acid amplification reaction such as polymerase chain reaction. The direction and design of the 5 'or 3' oligonucleotide primers or suitable linkers allows the covalent attachment of the resulting PCR products onto the surface of a support medium as described above. (and is also described, for example Shena, M. et al. (1995) 5 Science 270: 467-470). The nucleic acid micro-sets can also be constructed by oligonucleotide synthesis in situ in accordance with that described by Wodicka, L. et al. (1997) N i ur < ~ Biote '-noiogy 1'. "59-1367 Medi '• nt' --- m ** - OS (flfc 10 photolithographic, precisely defined regions of the matrix are exposed to light Protective groups that are photolabile are activated in this way and subjected to addition of nucleotides , while regions masked in relation to light are not subject to any 15 modification. Subsequent cycles of protection and activation with light allow the synthesis of different oligonucleotides at defined positions. Small defined regions of the genes of the invention can be synthesized in microassays by synthesis of 20 solid phase oligonucleotides. The nucleic acid molecules of the invention present in a mixture or mixture of nucleotides can be hybridized with the microsets. These nucleic acid molecules can be labeled according to standard methods. In In summary, nucleic acid molecules (e.g., mRNA molecules or AD molecules?) Are labeled by incorporation of labeled nucleotides either isotopically or fluorescently, e.g., during reverse transcription or synthesis of AD ?. Hybridization of nucleic acids labeled with microsets is described (for example, in Schena, M. et al. (1995) supra; Wodicka, L. et al. (1997), supra; and DeSaizieu A. et al. (1998) , supra). The detection and quantification of the hybridized molecule was made in vitro-incorporation. : > = radioactive arcs can be detected, for example, in accordance with that described in Schena, M. et al. (1995) supra) and fluorescent markers can be detected, for example, through the method of Salon et al. (1996) Genome Research 6: 639-645). The application of the sequences of the invention to microarray technology of AD ?, as described above, allows comparative analysis of different strains of C. glutamicum or other corynebacteria. For example, studies of variations between strains, based on profiles of individual transcripts and the identification of genes that are important for properties of specific and / or desired strains such as pathogenicity, productivity and tolerance to stress are facilitated by nucleic acid cluster methodologies . Likewise, comparisons of the expression profile of genes of the invention during the course of a fermentation reaction are possible using nucleic acid assembly technology. Example 13: Analysis of the dynamic characteristics of cell protein populations (Proteomia) The genes, compositions and methods of the invention can be applied to the study of the interactions and dynamic characteristics of protein populations, which are known as "proteomics". The protein populations of Icelandic include, without limitation, the density of W? 10 total protein of C. glutamicum (eg, compared to protein populations of other organisms), proteins that are active under specific environmental or metabolic conditions (eg, during fermentation, at high or low temperature, or 15 at a high or low pH), or the proteins that are active during specific growth and development phases. Protein populations can be analyzed by several well-known techniques, such as for example gel electrophoresis. Cell proteins can be obtained, for example, by lysis or extraction, and can be separated from each other using various electrophoretic techniques. Electrophoresis in sodium dodecylsulfate - polyacrylamide gel (SDS-PAGE) separates proteins largely based on their molecular weight. Isoelectric focusing polyacrylamide gel electrophoresis (IEF-PAGE) separates proteins by their isoelectric point (which reflects not only the amino acid sequence but also • post translational modifications of the protein). Another, more preferred, method of protein analysis is the consecutive combination of IEF-PAGE and SDS-PAGE, which is known as 2-D-gel electrophoresis (described, for example, in Hermann et al. (1998) Electrophoresis 19 ~: 'x.l- rí2 l Fountoul ^ i? ec al (1 93 ^ E 1 - '•• -etrophores s 1 * 9 • 10 1193-1202 Lange et al. (1997) Eiectrophoresis 18 1184-1192 Antelmann et al. (1997) Electrophoresis 18 1451-1463). Other separation techniques can also be used for the separation of proteins, such as capillary gel electrophoresis; such techniques are 15 well known. Proteins separated by these methods can be visualized by standard techniques, for example staining or marking. Suitable stains are known in the art and include Coomassie Brilliant Blue, silver staining, colorants 20 fluorescents such as Sypro Ruby (Molecular Probes). The inclusion of radioactively labeled amino acids or other protein precursors (eg, j: S-methionine, j5S-cysteine, amino acids marked with '4C, ~ "N-amino acids, amino acids labeled with iJC or" "NO3 or" NH " ~) in The medium of C. glutamicum allows the labeling of proteins from these cells before their separation. Similarly, fluorescent labels can be used. These labeled proteins can be extracted, isolated • and separated according to the techniques previously described. Proteins visualized by these techniques can be further analyzed by measuring the amount of stain or marker that is used. The amount of • "" p "Othene \ * -? - a can be quantitatively used, for example, by optical methods and can be compared to the amount of other proteins in the same gel or other gels. of proteins in gels can be carried out for example, by optical comparison, spectroscopy, 15 image exploration and analysis of geies, or through the use of photographic films and sieves. Such techniques are well known. To determine the identity of a given protein, direct sequencing or other techniques can be used 20 standards. For example, N-terminal and / or C-terminal amino acid sequencing (eg Edman degradation) can be employed, as well as mass spectrometry (in particular MALDI or ESI techniques (see, for example, Langen et al. (1997)). Electrophoresis 18: 25 1184-1192)). The protein sequences provided here They can be used for the identification of C. glutamicum proteins by these techniques. The information obtained by these methods can be used to compare patterns of protein presence, activity or modification between different samples of various biological conditions (eg, different organisms, different fermentation time points, different media conditions, or different biotopes, among other) . Data obtained from these epitope, r or o -n combination with other techniques can be used for several applications, such as for comparing the behavior of several organisms in a given situation (eg, metabolic), to increase the productivity of strains that produce fine chemicals or to increase the efficiency of the production of fine chemicals. Equivalents Those of ordinary skill in the art will recognize, or may determine by using only routine experiments, many equivalents of the specific embodiments of the invention described herein. Such equivalents are within the framework of the following claims.

LIST OF SEQUENCES < 110 > BASF Aktiengesellschaft < 120 > GENE OF CORYNEBACTERIUM GLUTAMICUM THAT CODIFY PROTEINS INVOLVED IN THE SYNTHESIS OF MEMBRANE AND TRANSPORTATION OF MEMBRANE < 130 > BGI-125CPPC < 140 > PCT / IB00 / 00926 < 141 > 2000-06-23 < 150 > US 60/141031 < 151 > 1999-06-25 < 150 > DE 19931454 .3 < 151 > 1999-07-08 < 150 > DE 19931478 .0 < 151 > 1999-07-08 < 150 > DE 19931563 .9 < 151 > 1999-07-08 < 150 > DE 19932122 .1 < 151 > 1999-07-09 < 150 > DE 19932124 .8 < 151 > 1999-07-09 < 150 > DE 19932125. .6 < 151 > 1999-07-09 < 150 > DE 19932128., 0 < 151 > 1999-07-09 < 150 > DE 19932180. 9 < 151 > 1999-07-09 < 150 > DE 19932182. 5 < 151 > 1999-07-09 < 150 > DE 19932190. 6 < 151 > 1999-07-09 < 150 > DE 19932191. 4 < 151 > 1999-07-09 < 150 > DE 19932209. 0 < 151 > 1999-07-09 < 150 > DE 19932212. 0 < 151 > 1999-07-09 < 150 > DE 19932227. 9 < 151 > 1999-07-09 > _________! _.__; ._.____. * ___, ___., _.._... Hit ir ni Jiii «__ iiiü __ ^ __________ ^ < 150 > DE 19932228.7 < 151 > 1999-07-09 < 150 > DE 19932229.5 < 151 > 1999-07-09 < 150 > DE 19932230.9 < 151 > 1999-07-09 • < 150 > DE 19932927 .3 < 151 > 1999-07-14 < 150 > DE 19933005 .0 < 151 > 1999-07-14 < 150 > DE 19933006 .9 < 151 > 1999-07-14 < 150 > DE 19940764 .9 10 < 151 > 1999-08-27 < 150 > DE 19940765 .7 < 151 > 1999-08-27 • < 150 > DE 19940766.5 < 151 > 1999-08-27 < 150 > DE 19940830 .0 < 151 > 1999-08-27 < 150 > DE 19940831, .9 15 < 151 > 1999-08-27 < 150 > DE 19940832., 7 < 151 > 1999-08-27 < 150 > DE 19940833. 5 < 151 > 1999-08-27 < 150 > DE 19941378. 9 • < 151 > 1999-08-31 < 150 > DE 19941379. 7 20 < 151 > 1999-08-31 < 150 > FROM 19941395. 9 < 151 > 1999-08-31 < 150 > FROM 1994-2077. 7 < 151 > 1999-09-03 < 150 > FROM 1994-2078. 5 < 151 > 1999-09-03 < 150 > FROM 1994-2079. 3 25 < 151 > 1999-09-03 < 150 > DE 19942088.2 < 151 > 1999-09-03 < 160 > 678 < 210 > 1 < 211 > 578 • 5 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (555) < 223 > RXN03097 < 400 > 1 att tea gcc agt gca ggt gct ata ggt tgg tta att tta gaa tat att 48 Be Wing Be Wing Wing Gly Wing He Gly Trp Leu He Leu Glu Tyr He 1 5 10 15 10 ttt aaa aag acg here agt tta ctt gga ctt tta etc ggt gca tta gca 96 Phe Lys Lys Thr Thr Ser Leu Leu Gly Leu Leu Leu Gly Ala Leu Wing 20 25 30 • gga tta gtt gtt att act ect gca gca gga tat gta here tat ctt agt 144 Gly Leu Val Val He Thr Pro Wing Wing Gly Tyr Val Thr Tyr Leu Ser 35 40 45 gca here ata atg gct tta ata gga ggt ate tgt tgt tat att gtc att 192 Ala Thr He Met Ala Leu He Gly Gly He Cys Cys Tyr He Val He 50 55 60 aat tac ate aag gta aaa cta aaa tat cat gat gca tta gat gca ttt 240 Asn Tyr He Lys Val Lys Leu Lys Tyr His Asp Ala Leu Asp Ala Phe 65 70 75 80 1 < Ggt att cat ggt gtt ggt att att ggt gct gtt tta here gca gtt 288 Gly He His Gly Val Gly Gly He He Gly Ala Val Leu Thr Ala Val 85 90 95 ttc caa agt aaa aaa gcc aat ect gac att gag aat ggc ttt att tat 336 Phe Gln Ser Lys Lys Wing Asn Pro Asp He Glu Asn Gly Phe He Tyr 100 105 110 act ggt gac ata cat ata ata ctt gta ca ata ata tta tgt gta here gca 384 Thr Gly Asp He His He He Leu Val Gln He Leu Cys Val Thr Wing 115 120 125 gtt gta att ttt agt ate gtc atg acg ttt att att gcg aaa gta att 432 Val Val He Phe Ser He Val Met Thr Phe He He Wing Wing Lys Val He 130 135 140 20 aaa tta att here cca tta tet gtt acg gaa caa gaa acg aat ata gga 480 Lys Leu He Thr Pro Leu Ser Val Thr Glu Gln Glu Thr Asn He Gly 145 150 155 160 tta gac aag att gtt falls ggt gaa cat gct tac ttt gaa ggt gag cta 528 Leu Asp Lys He Val His Gly Glu His Wing Tyr Phe Glu Gly Glu Leu 165 170 175 aat ttc aat aaa cat att cga tat ttatat ttacat tat 578 Asn Arg Phe Asn Lys His He Arg Tyr 180 185 < 210 > 2 < 211 > 185 25 < 212 > PRT - --- «mfBtt-tAh-«. < 213 > Corynebacterium glutamicum < 400 > 2 Be Ser Wing Be Wing Gly Wing He Gly Trp Leu He Leu Glu Tyr He 1 5 10 15 Phe Lys Lys Thr Thr Ser Leu Leu Gly Leu Leu Leu Gly Wing Leu Wing 20 25 30 Gly Leu Val Val He Thr Pro Wing Ala Gly Tyr Val Thr Tyr Leu Ser 35 40 45 • Ala Thr He Met Ala Leu He Gly Gly He Cys Cys Tyr He Val He 50 55 60 Asn Tyr He Lys Val Lys Leu Lys Tyr His Asp Ala Leu Asp Ala Phe 65 70 75 80 Gly He His Gly Val Gly Gly He He Gly Wing Val Leu Thr Wing Val 85 90 95 Phe Gln Ser Lys Lys Wing Asn Pro Asp He Glu Asn Gly Phe He Tyr 100 105 110 Thr Gly Asp He His He He Le Le Val Gln He Leu Cys Val Thr Wing 115 120 125 Val Val He Phe Ser He Val Met Thr Phe He He Wing Wing Lys Val He 10 130 135 140 Lys Leu He Thr Pro Leu Ser Val Thr Glu Gln Glu Thr Asn He Gly 145 150 155 160 Leu Asp Lys He Val His Gly Glu His Wing Tyr Phe Glu Gly Glu Leu • 165 170 175 Asn Arg Phe Asn Lys His He Arg Tyr 180 185 < 210 > 3 < 211 > 373 < 212 > DNA < 213 > Corynebacterium glutamicum 15 < 220 > < 221 > CDS < 222 > (101) .. (373) < 223 > RXA02099 < 400 > 3 tagtte tggttcaagg ggtgtcaatc ccaaaaggca ctccttgaac tcatgaaaaa 60 gcttgacaaa acttcaacgt caaaggaggt catccacgct atg ggt gca gat caa 115 Met Gly Wing Asp Gln 1 5 att gca gca gtc tcc ggc aat tea gct tgg atg ctg atg tcc gcg tcg 163 20 Wing Wing Wing Val Ser Gly Asn Wing Wing Trp Met Leu Met Ser Wing Being 10 15 20 etc gtg ctg cta atg here cca gca ctg gca ctt ttc tat ggc ggc atg 211 Leu Val Leu Leu Met Thr Pro Ala Leu Ala Leu Phe Tyr Gly Gly Met 25 30 35 tet cgt caa aag tcc gtg etc aac atg atg atg atg tcc ttt gga gca 259 Be Arg Gln Lys Ser Val Leu As Met Met Met Met Met Be Phe Gly Wing 40 45 50 ttg ggc gtc gtt act gtt att tac etc ttg tgg ggg tgg tgg atg tet 307 Leu Gly Val Val Thr Val He Tyr Leu Leu Trp Gly Trp Ser Met Ser 55 60 65 tat gga acc ata tea ate gcg gga ate ttt gct aac ect ttt gag ttc 355 25 Tyr Gly Thr Gln Ser He Wing Gly He Phe Wing Asn Pro Phe Glu Phe 70 75 80 85 ttc ggt ctt aaa gat tcc 373 Phe Gly Leu Lys Asp Ser 90 < 210 > 4 < 211 > 91 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 4 Met Gly Wing Asp Gln He Wing Wing Val Ser Gly Asn Being Wing Trp Met 1 5 10 15 Leu Met Ser Wing Being Leu Val Leu Leu Met Thr Pro Wing Leu Wing Leu 20 25 30 Phe Tyr Gly Gly Met Ser Arg Gln Lys Ser Val Leu Met Met Met Met 35 40 Met Met Ser Phe Gly Ala Leu Gly Val Val Thr Val He Tyr Leu Leu Trp 50 55 60 Gly Trp Ser Met Ser Tyr Gly Thr Gln Ser He Wing Gly He Phe Wing 10 65 70 75 80 Asn Pro Phe Glu Phe Phe Gly Leu Lys Asp Ser 85 90 < 210 > 5 < 211 > 879 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (856) 15 < 223 > RXA00104 < 400 > 5 tgcaaagaca tcccggaacc actccgctac ttgaggtcgg aatcgggaaa gaatgctttt 60 agccatgcct taatgtaacc aaacatctag aattgagaac atg act gct cag att 115 Met Thr Wing Gln He 1 5 gat gat tcg ate etc acc cat cgt etc gcc ca ggc acc gga gaa ate 163 Asp Asp Ser He Leu Thr His Arg Leu Wing Gln Gly Thr Gly Glu He 10 15 20 etc aaa ggt gtc cgc aat gtt ggg gtg tta aga ggt cgg aat etc ggt 211 Leu Lys Gly Val Arg Asn Val Gly Val Leu Arg Gly Arg Asn Leu Gly 20 25 30 35 gat gcc ggc gac gaa etc gca cat agt tgg att gct cga gtg ttg gag 259 Asp Wing Gly Asp Glu Leu Wing Gln Ser Trp He Wing Arg Val Leu Glu 40 45 50 cag falls cgc ccc aac gat gga ttc ctg tet gaa gaa gcc gcc gac aac 307 Gln His Arg Pro Asn Asp Gly Phe Leu Ser Glu Glu Wing Wing Asp Asn 55 60 65 cca gac cgc cta tcc aag gac cgc gtg tgg ate ate ccc etc gac 355 Pro Asp Arg Leu Ser Lys Asp Arg Val Trp He He Asp Pro Leu Asp 70 75 80 85 ggc acc aaa gaa ttc gcc acc ggc cgc cag gac tgg gca gta gta cae 403 Gly Thr Lys Glu Phe Wing Thr Gly Arg Gln As p Trp Ala Val His He 25 90 95 100 gca ctg gta gaa aac ggt gtt ccc acc falls gcc gct gtt gcc etc ccc 451 Ala Leu Val Glu Asn Gly Val Pro Thr His Ala Ala Val Gly Leu Pro 105 110 115 gac ctt ggc gtg gtg ttc falls tcc gct gat gcc cgc gcc gtg act ggc 499 Asp Leu Gly Val Val Phe His Ser Wing Asp Wing Arg Wing Val Thr Gly 120 125 130 ect tac tc aag gtc ate gcc ate tcc falls aac cgc cca cca aag gtt 547 Pro Tyr Ser Lys Val He Wing He Ser His Asn Arg Pro Pro Lys Val 135 140 145 • gct cta tet tgc gca gag cag etc ggc ttt gaa acc aag gcc ctt gga 595 Wing Leu Ser Cys Wing Glu Gln Leu Gly Phe Glu Thr Lys Wing Leu Gly 150 155 160 165 tcc gca ggc gct aaa gca atg falls gtt etc etc ggt gac tac gac gcc 643 Ser Wing Gly Wing Lys Wing Wing His Val Leu Leu Gly Asp Tyr Asp Wing 170 175 180 tac tet tet gcc ggc ggc ca ta tac gag tgg gat tcc gca gca cca gtc 691 Tyr He His Wing Gly Gly Gln Tyr Glu Trp Asp Wing Wing Pro Val 185 190 195 ggc gtc tgc aag gca gg ggc ttg falls tgc tcc agg etc gac ggt tcc 739 Gly Val Cys Lys Wing Wing Gly Leu His Cys Ser Arg Le u Asp Gly Ser 10 200 205 210 gag ctg accac aac aac aaa gac acc atc cca gac ate ttg ate 787 Glu Leu Thr Tyr Asn Asn Lys Asp Thr Tyr Met Pro Asp He Leu He 215 220 225 • tgt cgc ect gaa ctt gca gat gaa ctt etc gag atg tgc gcg aag ttc 835 Cys Arg Pro Glu Leu Wing Asp Glu Leu Leu Glu Met Cys Wing Lys Phe 230 235 240 245 tac gag gag aat gga act tac taacgctgtt atgatgacgg cat 879 Tyr Glu Glu Asn Gly Thr Tyr 250 < 210 > 6 15 < 211 > 252 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 6 Met Thr Wing Gln He Asp Asp Being He Leu Thr His Arg Leu Wing Gln 1 5 10 15 Gly Thr Gly Glu He Leu Lys Gly Val Arg Asn Val Gly Val Leu Arg 20 25 30 • Gly Arg Asn Leu Gly Asp Wing Gly Asp Glu Leu Wing Gln Ser Trp He 35 40 45 Wing Arg Val Leu Glu Gln His Arg Pro Asn Asp Gly Phe Leu Ser Glu 20 50 55 60 Glu Wing Wing Asp Asn Pro Asp Arg Leu Ser Lys Asp Arg Val Trp He 65 70 75 80 He Asp Pro Leu Asp Gly Thr Lys Glu Phe Wing Thr Gly Arg Gln Asp 85 90 95 Trp Wing Val His He Wing Leu Val Glu Asn Gly Val Pro Thr His Wing 100 105 110 Wing Val Gly Leu Pro Asp Leu Gly Val Val Phe His Ser Wing Asp Ala 115 120 125 Arg Ala Val Thr Gly Pro Tyr Ser Lys Val He Ala He Ser His Asn 130 135 140 Arg Pro Pro Lys Val Ala Leu Ser Cys Ala Glu Gln Leu Gly Phe Glu 25 145 150 155 160 Thr Lys Ala Leu Gly Be Ala Gly Ala Lys Ala Met His Val Leu Leu 165 170 175 Gly Asp Tyr Asp Ala Tyr He His Wing Gly Gly Gln Tyr Glu Trp Asp 180 185 190 Ser Ala Ala Pro Val Gly Val Cys Lys Ala Ala Gly Leu His Cys Ser 195 200 205 Arg Leu Asp Gly Ser Glu Leu Thr Tyr Asn Asn Lys Asp Thr Tyr Met 210 215 220 Pro Asp He Leu He Cys Arg Pro Glu Leu Wing Asp Glu Leu Leu Glu • 225 230 235 240 Met Cys Ala Lys Phe Tyr Glu Glu Asn Gly Thr Tyr 245 250 < 210 > 7 < 211 > 875 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS 10 < 222 > (101) .. (859) < 223 > RXA01420 < 400 > 7 • cga; agtticae < gact¡acaggc a'ttacctggg tgetgatttt gcgcgagtaa; agctgtggct 60 gcggaatgcg < ctgctcaticc acacgtgga; a tcictgattgg gtg acg ctg ggt gga 115 Val Thr Leu Gly Gly 1 ttg aat gta cca tcg tgg tcg ctg ggc gcg gaa atg ctg ttc tac ctg 163 Leu Asn Val Pro Ser Trp Ser Leu Gly Wing Glu Met Leu Phe Tyr Leu 10 15 20 acg tcc ccg ctg ttt att ccg tta gtg cgc aaa gtg aag ggc gtg ggc 211 15 Thr Phe Pro Leu Phe He Pro Leu Val Arg Lys Val Lys Gly Val Gly 25 30 35 aac tgg tgg gca ttt ggc ate acc ttt gcc gtg age ctg gcg ctg att 259 Asn Trp Trp Wing Phe Gly He Thr Phe Wing Val Ser Leu Wing Leu He 40 45 50 here gtg att falls ttt tat gcg gac gga cca aag ggg att gag aac ttc 307 Thr Val He His Phe Tyr Wing Asp Gly Pro Lys Gly He Glu Asn Phe 55 60 65 ttt gtt ect cgc ctg tgg gac acc aat gtg tea ccg gtc gcg gaa gtt 355 • Phe Val Pro Arg Leu Trp Asp Thr Asn Val Ser Pro Val Val Glu Val 70 75 80 8 855 falls gcc gat cca gtg tgg ttt atg cag gaa gaa aatttt cccccc ggttgg ccttgg ggaaaa 403 20 His Wing Asp Pro Val Trp Phe Met Gln Glu Glu H Hee P Prroo V Vaall L Leeuu G Glluu 90 95 110000 tet tac tgg ctg tet tac tac tc ccg ctg acc aaggaa eettcc aattee ggaagg ttttcc 451 Be Tyr Trp Leu Be Tyr Tyr Phe Pro Leu Thr A Arrgg L Leeuu H Hee G Glluu P Phhee 105 110 111155 tac etc ggt gtg ttt ggc gcg aag ctg gtt gct gaa ggc atg ttt aaa 499 Tyr Leu Gly Val Phe Gly Ala Lys Leu Val Wing Glu Gly Met Phe Lys 120 125 130 aac acc aac ate acc ate ccg ctg ate gca ctg gct gtt tteett tttttt ggtttt 547 Asn Thr Asn He Thr He Pro Leu He Wing Leu Wing Val SSeerr PPhhee V Vaall 135 140 145 gct act tgg ttt gtg cca ctg gca ttc aag atg tet gtc aattee aattgg ttcccc 595 25 Wing Thr Trp Phe Val Pro Leu Wing Phe Lys Met Ser Val HHee MMeett SSeerr - -nrAtfeiri 150 155 160 165 ctg cca atg gct ttt gtt gtg gca acg ctt gcg gtg aga gac att gaa 643 Leu Pro Met Ala Phe Val Val Ala Thr Leu Ala Val Arg Asp He Glu 170 175 180 ggc aag agt ggg gaa ate gcc tcg ect cgc gca gtt ttg ttg ggt aat 691 Gly Lys Ser Gly Glu He Ala Ser Pro Arg Ala Val Leu Leu Gly Asn 185 190 195 att tcc ttt gcc ttc tac atg gtg cat ttc ccc gtc atg gtg ttt gtg 739 Be Ser Phe Ala Phe Tyr Met Val Gln Phe Pro Val Val Val Val Phe Val • 200 205 210 cag cgc tat ttc att gct ggc aaa gaa tac ggc ttc ctt ggc tgg ggg 787 Gln Arg Tyr Phe He Wing Gly Lys Glu Tyr Gly Phe Leu Gly Trp Wing 215 220 225 ttc tat gca gtg gtg tgt ttc ate gtg tcg gtc att etc gcg tgg gtg 835 Phe Tyr Ala Val Val Cys Phe He Val Ser Val He Leu Wing Trp Val 230 235 240 245 ctg tta ect tcg ttg atg ate ctt taataaggcc acggaa 875 Leu Leu Pro Ser Leu Met He Leu 250 10 < 210 > 8 < 211 > 253 < 212 > PRT < 213 > Corynebacterium glutamicum • < 400 > 8 Val Thr Leu Gly Gly Leu Asn Val Pro Ser Trp Ser Leu Gly Wing Glu 1 5 10 15 Met Leu Phe Tyr Leu Thr Phe Pro Leu Phe He Pro Leu Val Arg Lys 20 25 30 Val Lys Gly Val Gly Asn Trp Trp Wing Phe Gly He Thr Phe Wing Val 35 40 45 15 Ser Leu Ala Leu He Thr Val He His Phe Tyr Wing Asp Gly Pro Lys 50 55 60 Gly He Glu Asn Phe Phe Val Pro Arg Leu Trp Asp Thr Asn Val Ser 65 70 75 80 Pro Val Ala Glu Val His Wing Asp Pro Val Trp Phe Met Gln Gllu Glu 85 90 95 He Pro Val Leu Glu Ser Tyr Trp Leu Ser Tyr Tyr Phe Pro Leu Thr 100 105 110 Arg Leu He Glu Phe Tyr Leu Gly Val Phe Gly Ala Lys Leu Val Wing • 115 120 125 Glu Gly Met Phe Lys Asn Thr Asn He Thr He Pro Leu He Wing Leu 130 135 140 20 Wing Val Ser Phe Val Wing Thr Trp Phe Val Pro Leu Wing Phe Lys Met 145 150 '"155 160 Ser Val He Met Being Leu Pro Met Wing Phe Val Val Wing Thr Leu Wing 165 170 175 Val Arg Asp He Glu Gly Lys Ser Gly Glu He Wing Ser Pro Arg Wing 180 185 190 Val Leu Leu Gly Asn He Ser Phe Wing Phe Tyr Met Val Gln Phe Pro 195 200 205 Val Met Val Phe Val Gln Arg Tyr Phe He Wing Gly Lys Glu Tyr Gly 210 215 220 Phe Leu Gly Trp Wing Phe Tyr Wing Val Val Cys Phe He Val Ser Val 225 230 235 240 25 He Leu Wing Trp Val Leu Leu Pro Ser Leu Met He Leu 245 250 < 210 > 9 < 211 > 1983 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1960) < 223 > RXN02581 acggtcactc • gctcaagt, ag tigttaigtttg caaaagtaat aaa, atgttca • tctttgtcga 60 tggtcacaat, agtc, attaaa g, aattgtaai 3 aggggt ^ treac atg gat tta gat aaa 115 Met Asp Leu Asp Lys 1 5 gcg att ggt tea ttc ttc gat gag aat gga gaa ate aac ctt ect cca 163 Wing He Gly Be Phe Phe Asp Glu Asn Gly Glu He Asn Leu Pro Pro 10 15 20 10 ttc cta act ttg gca gcc atg ggt gag ttc atg tac cag gct gac ate 211 Phe Leu Thr Leu Wing Wing Met Gly Glu Phe Met Tyr Gln Wing Asp He 25 30 35 gct gag ggc ggc ggg gat aaa cca cgc atg cat ttc tgg gac ttc tcc 259 Wing Glu Gly Gly Gly Asp Lys Pro Arg Met His Phe Trp Asp Phe Ser 40 45 50 gaa gac cgc gat ggc aag ctg att cag tac ac cga aac gag ate gat 307 Glu Asp Arg Asp Gly Lys Leu He Gln Tyr Thr Arg Asn Glu He Asp 55 60 65 act cgt ate aag gct gta gca ggc cgt ttg cag cag gtc gcc acc ctg 355 Thr Arg He Lys Wing Val Wing Gly Arg Leu Gln Gln Val Wing Thr Leu 70 75 80 85 15 ggt gat cgt gca gcg ate ctg gct aac aac age ect gag tac att ttc 403 Gly Asp Arg Ala Ala He Leu Ala Asn Asn Ser Pro Glu Tyr He Phe 90 95 100 age ttc etc ggc gcg ate tac gct ggc atg gtc ect gtg ccg ctt tat 451 Be Phe Leu Gly Wing He Tyr Wing Gly Met Val Val Pro Pro Leu Tyr 105 110 115 gat cca aac gag cca gga falls gca gac drops etc aac gct gtt ttc gca 499 Asp Pro Asn Glu Pro Gly His Wing Asp His Leu Asn Wing Val Phe Wing 120 125 130 • gac age gag cca gtt gtc gtt ctg acc aac tcc aag tcc gca ggt gcc 547 Asp Ser Glu Pro Val Val Val Leu Thr Asn Ser Lys Ser Wing Gly Wing 135 140 145 20 gtg cgc aag falls ttc tcc age ctt cca gct gca gaa cgc cca cgc ate 595 Val Arg Lys His Phe Ser Ser Leu Pro Wing Wing Glu Arg Pro Arg He 150 155 160 165 etc tet gta gat tcc ttg ect gat tet etc gcg gat tet tac gag aac 643 Leu Ser Val Asp Ser Leu Pro Asp Ser Leu Wing Asp Ser Tyr Glu Asn 170 175 180 cca atg ctg acc gaa gcc ggc cgc cgc ctg gct gct ctg cgc cag tcc 691 Pro Met Leu Thr Glu Wing Gly Arg Arg Leu Wing Wing Leu Arg Gln Ser 185 185 195 gcg ccc att gat ctg acc gca ttc ctg cag tac acc tcc ggc tcc acc 739 Wing Pro He Asp Leu Thr Wing Phe Leu Gln Tyr Thr Ser Gly Ser Thr 200 205 210 25 cga acc cca gct ggc gtt gtt ctg acc aac cgc tcc ate ctg acc aac 787 Arg Thr Pro Wing Gly Val Val Leu Thr Asn Arg Ser He Leu Thr Asn 215 220 225 gtc ttg cag ate ttc age gcc gca cag ctg aaa acc cca ctg cgc ctg 835 Val Leu Gln He Phe Be Wing Wing Gln Leu Lys Thr Pro Leu Arg Leu 230 235 240 245 gtt tea tgg ctg cca ctg falls falls gac atg ggc att ate etc gcg gcg 883 Val Ser Trp Leu Pro Leu His His Asp Met Gly He He Leu Ala Ala 250 255 260 • ttt gtc act atg ctt ggc ctg gac aac gag ttc atg aac cca cgc gat 931 Phe Val Thr Met Leu Gly Leu Asp Asn Glu Phe Met Asn Pro Arg Asp 265 270 275 ttc gtg cag ect tcc cgc tgg att aag cag etc aac cgt cgc gaa 979 Phe Val Gln Gln Pro Ser Arg Trp He Lys Gln Leu Asn Arg Arg Glu 280 285 290 age gac gtg gac gtt aac gtc tac acc gtg gtt act aac ttc gcc etc 1027 Be Asp Val Asp Val Asn Val Tyr Thr Val Val Pro Asn Phe Ala Leu 295 300 305 gag ctt gca gca cgc tac gca aag cca gca gaga gga gag acc ctg gat 1075 Glu Leu Wing Wing Arg Tyr Wing Lys Pro Wing Glu Gly Glu Thr Leu Asp 310 315 320 325 10 ctt tcc gca ttg gat gcc ate att ate ggt tcc gag cca gtc here gaa 1123 Leu Be Wing Leu Asp Wing He He He Gly Ser Glu Pro Val Thr Glu 330 335 340 aac gct ctg acc acc ttc cgt gaa gct ttc gag ect tac ggc ctg ect 1171 Asn Ala Leu Thr Thr Phe Arg Glu Wing Phe Glu Pro Tyr Gly Leu Pro 345 350 355 gtt cag acc ctg ccttct tcc tac ggt ctt gca gaa gca tcc ctg ctg 1219 Val Gln Thr Leu Arg Pro Ser Tyr Gly Leu Wing Glu Wing Ser Leu Leu 360 365 370 gtc acc acc acca ccac acc gaa aac cgc cca ctg ate tcc tac tcc gac 1267 Val Thr Thr Pro Gln Thr Glu Asn Arg Pro Leu He Ser Tyr Phe Asp 375 380 385 15 cgc gag gcc ttg gcc gaa aac cgc gtt gag ctt gta gaa aag ggc aat 1315 Arg Glu Ala Leu Ala Glu Asn Arg Val Glu Leu Val Glu Lys Gly Asn 390 395 400 405 aac aag gct gtt gtc gtc tcc aac ggc cag gtt gca gcc cca cag 1363 Asn Lys Wing Val Wing Phe Val Being Asn Gly Gln Val Wing Wing Pro Gln 410 415 420 cag ctg gtc ate gtt gat tcc gaa acc gga acc gag ctg gca gac ggc 1411 Gln Leu Val He Val Asp Ser Glu Thr Gly Thr Glu Leu Wing Asp Gly • 425 430 435 cag ate ggc gaa ate tgg acc fall ggc gaa aac act gct gca ggt tac 1459 Gln He Gly Glu He Trp Thr His Gly Glu Asn Thr Ala Wing Gly Tyr 440 445 450 20 etc gac cgc gag gaa gac acc gca gaa acc ttc cgc aac cgt ctg acc 1507 Leu Asp Arg Glu Glu Asp Thr Wing Glu Thr Phe Arg Asn Arg Leu Thr 455 460 465 acc cgc ctg gaa gaa aac tcc cgc gca gaa ggt gct gcc gac gac aac 1555 Thr Arg Leu Glu Glu Asn Ser Arg Wing Glu Gly Wing Wing Asp Asp Asn 470 475 480 485 tac tgg atg gcc acc ggt gac etc ggc gtc ate gta gac aac gag etc 1603 Tyr Trp Met Wing Thr Gly Asp Leu Gly Val He Val Asp Asn Glu Leu 490 495 500 tac ate acc ggt cgt ctg aag gac etc ate gtt gtc gca ggc cga aac 1651 Tyr He Thr Gly Arg Leu Lys Asp Leu He Val Val Wing Gly Arg Asn 505 510 515 25 falls tac cca cag gac ate gag tac acc gtc cag gct gct tcc gca cae 1699 His Tyr Pro Gln Asp He Glu Tyr Thr Val Gln Ala Wing Ser Ala His 520 525 530 ate cgt gca gat tcc gc gca gca gtc gca gc gca cca ggc gat gac att 1747 He Arg Wing Asp Ser Val Wing Wing Phe Wing Val Pro Gly Asp Asp He 535 540 545 gaa aag etc ate ate ctg gca gaa cgc gac ac act gca aac gaac gcc 1795 Glu Lys Leu He He Leu Wing Glu Arg Asp Thr Thr Wing Asn Glu Wing 550 555 560 565 gac gat gca gct gct gaa gaa gca ate cgc tcc gcc gtt ggc act gca 1843 Asp Asp Ala Ala Wing Glu Glu Wing He Arg Wing Wing Val Gly Thr Wing 570 575 580 fall ggt gtt gtt cca gaa gag ate cgt ate etc gca ect gac gag ate 1891 His Gly Val Val Pro Glu Glu He Arg He Leu Ala Pro Asp Glu He 585 590 595 gcg cgt tcc tcc tcc gga aag ate gca cgc cgc gtc aac cag cgc aac 1939 Wing Arg Being Ser Gly Lys He Wing Arg Arg Val Asn Gln Arg Asn 600 605 610 tac att cag gaa ca gct aac tagttctttg caga Agg Caccgc 1983 Tyr He Gln Glu Gln Ala Asn 615 620 10 < 210 > 10 < 211 > 620 < 212 > PRT • < 213 > Corynebacterium glutamicum < 400 > 10 Met Asp Leu Asp Lys Wing He Gly Be Phe Phe Asp Glu Asn Gly Glu 1 5 10 15 He Asn Leu Pro Pro Phe Leu Thr Leu Wing Wing Met Gly Glu Phe Met 20 25 30 Tyr Gln Wing Asp He Wing Glu Gly Gly Gly Asp Lys Pro Arg Met His 15 35 40 45 Phe Trp Asp Phe Ser Glu Asp Arg Asp Gly Lys Leu He Gln Tyr Thr 50 55 60 Arg Asn Glu He Asp Thr Arg He Lys Wing Val Wing Gly Arg Leu Gln 65 70 75 80 Gln Val Ala Thr Leu Gly Asp Arg Ala Ala Ala Leu Ala Asn Asn Ser 85 90 95 Pro Glu Tyr He Phe Ser Phe Leu Gly Ala He Tyr Ala Gly Met Val 100 105 110 • Pro Val Pro Leu Tyr Asp Pro Asn Glu Pro Gly His Wing Asp His Leu 115 120 125 Asn Wing to Phe Wing Asp Ser Glu Pro Val Val Val Leu Thr Asn Ser 20 130 135 140 Lys Ser Wing Gly Wing Val Arg Lys His Phe Ser Ser Leu Pro Ala Wing 145 150 155 160 Glu Arg Pro Arg He Leu Ser Val Asp Ser Leu Pro Asp Ser Leu Wing 165 170 175 Asp Ser Tyr Glu Asn Pro Met Leu Thr Glu Wing Gly Arg Arg Leu Wing 180 185 190 Wing Leu Arg Gln Ser Wing Pro He Asp Leu Thr Wing Phe Leu Gln Tyr 195 200 205 Thr Ser Gly Ser Thr Arg Thr Pro Wing Gly Val Val Leu Thr Asn Arg 210 215 220 Ser He Leu Thr Asn Val Leu Gln He Phe Ser Ala Ala Gln Leu Lys 25 225 230 235 240 Thr Pro Leu Arg Leu Val Ser Trp Leu Pro Leu His His Asp Met Gly 245 250 255 He He Leu Ala Ala Phe Val Thr Met Leu Gly Leu Asp Asn Glu Phe 260 265 270 Met Asn Pro Arg Asp Phe Val Gln Gln Pro Ser Arg Trp He Lys Gln 275 280 285 Leu Asn Arg Arg Glu As Asp Val Asp Val Asn Val Tyr Thr Val Val 290 295 300 • Pro Asn Phe Ala Leu Glu Leu Ala Ala Arg Tyr Ala Lys Pro Ala Glu 305 310 315 320 Gly Glu Thr Leu Asp Leu Ser Ala Leu Asp Ala He He He Gly Ser 325 330 335 Glu Pro Val Thr Glu Asn Ala Leu Thr Thr Phe Arg Glu Ala Phe Glu 340 345 350 Pro Tyr Gly Leu Pro Val Gln Thr Leu Arg Pro Ser Tyr Gly Leu Ala 355 360 365 Glu Ala Ser Leu Leu Val Thr Thr Pro Gln Thr Glu Asn Arg Pro Leu 370 375 380 He Ser Tyr Phe Asp Arg Glu Ala Leu Ala Glu Asn Arg Val Glu Leu 385 390 395 400 10 Val Glu Lys Gly Asn Asn Lys Ala Val Ala Phe V to Being Asn Gly Gln 405 410 415 Val Ala Ala Pro Gln Gln Leu Val He Val Asp Ser Glu Thr Gly Thr 420 425 430 • Glu Leu Wing Asp Gly Gln He Gly Glu He Trp Thr His Gly Glu Asn 435 440 445 Thr Wing Wing Gly Tyr Leu Asp Arg Glu Glu Asp Thr Wing Glu Thr Phe 450 455 460 Arg Asn Arg Leu Thr Thr Arg Leu Glu Glu Asn Ser Arg Wing Glu Gly 465 470 475 480 Wing Wing Asp Asp Asn Tyr Trp Met Wing Thr Gly Asp Leu Gly Val He 485 490 495 15 Val Asp Asn Glu Leu Tyr He Thr Gly Arg Leu Lys Asp Leu He Val 500 505 510 Val Ala Gly Arg Ala Asp His Tyr Pro Gln Asp He Glu Tyr Thr Val Gln 515 520 525 Wing Wing His Wing He Arg Wing Asp Ser Val Wing Wing Phe Wing Val 530 535 540 Pro Gly Asp Asp He Glu Lys Leu He He Leu Ala Glu Arg Asp Thr 545 550 555 560 Thr Wing Asn Glu Wing Asp Asp Wing Wing Wing Glu Glu Wing He Arg Ser 565 570 575 Wing Val Gly Thr Wing His Gly Val Val Pro Glu Glu He Arg He Leu 580 585 590 20 Wing Pro Asp Glu He Wing Arg Being Ser Gly Lys He Wing Arg Arg 595 600 605 Val Asn Gln Arg Asn Tyr He Gln Glu Gln Wing Asn 610 615 620 <; 210 > 11 < 211 > 1550 < 212 > DNA < 213 > Corynebacterium glutam cum < 220 > < 221 > CDS 25 < 222 > (1) .. (15271 a thousand & i & mHílÉik - "^ ** ..- * .__. c * •» - »• < 223 > FRXA02581 < 400 >c 11 gtc ect gtg ccg ctt tat gat cca aac gag cca gga cae gca gac falls 48 Val Pro Pro Leu Tyr Asp Pro Asn Glu Pro Gly His Wing Asp His 1 5 10 15 etc aac gct gtt ttc gca gac age gag cca gtt gtc gtt ctg acc aac 96 Leu Asn Ala Val Phe Ala Asp Ser Glu Pro Val Val Val Leu Thr Asn 20 25 30 • tcc aag tcc gca ggt gcc gtg cgc aag falls ttc tcc age ctt cca cct gct 144 Ser Lys Ser Wing Gly Wing Val Arg Lys His Phe Ser Ser Leu Pro Wing 35 40 45 gca gac cgc cca cgc ate etc tet gta gat tcc ttg ect gat tet etc 192 Wing Glu Arg Pro Arg He Leu Ser Val Asp Ser Leu Pro Asp Ser Leu 50 55 60 gcg gat tet tac gag aac cca atg ctg acc gaa gcc ggc cgc cgc ctg 240 Wing Asp Ser Tyr Glu Asn Pro Met Leu Thr Glu Wing Gly Arg Arg Leu 65 70 75 80 gct gct ctg cgc cag tcc gcg ccc att gat ctg acc gca ttc ctg cag Ala Ala Leu Arg Gln Ser Ala Pro He Asp Leu Thr Ala Phe Leu Gln 10 85 90 95 tac acc tcc ggc tcc acc acga acc cca gct ggc gtt gtt ctg acc aac 336 Tyr Thr Ser Gly Ser Thr Arg Thr Pro Wing Gly Val Val Leu Thr Asn 100 105 110 • cgc tcc ate ctg acc aac gtc ttg cag ate ttc age gcc gca cag ctg 384 Arg Ser He Leu Thr Asn Val Leu Gln He Phe Ser Ala Ala Gln Leu 115 120 125 aaa acc cca ctc cgc ctg gtt tea tgg ctg cca ctg cae cae gac atg 432 Lys Thr Pro Leu Arg Leu Val Ser Trp Leu Pro Leu His His Asp Met 130 135 140 ggc att ate etc gcg gcg ttt gtc act atg ctt ggc ctg gac aac gag 480 Gly He He Leu Wing Wing Phe Val Thr Met Leu Gly Leu Asp Asn Glu 15 145 150 155 160 ttc atg aac cca cgc gat ttc gtg cag cag ect tcc cgc tgg att aag 528 Phe Met Asn Pro Arg Asp Phe Val Gln Gln Pro Ser Arg Trp He Lys 165 170 175 cag etc aac cgt cgc gaa age gac gtg gac gtt aac gtc tac acc gtg 576 Gln Leu Asn Arg Arg Glu As Asp Val Asp Val Asn Val Tyr Thr Val 180 185 190 gtt ect aac ttc gcc etc gag ctt gca gca cgc tac gca aag cca gca 624 Val Pro Asn Phe Wing Leu Glu Leu Wing Wing Arg Tyr Wing Lys Pro Wing 195 200 205 gag gga gag acc ctg gat ctt tc gca ttg gat gcc ate att ate ggt 672 Glu Glu Glu Thr Leu Asp Leu Be Wing Leu Asp Wing He He He Gly 20 210 215 220 tcc gag cca gtc here gaa aac gct ctg acc acc ttc cgt gaa gct ttc 720 Ser Glu Pro Val Thr Glu Asn Ala Leu Thr Thr Phe Arg Glu Ala Phe 225 230 235 240 gag ect tac ggc ctg ect gtt cag acc ctg ccttct tcc tac ggt ctt 768 Glu Pro Tyr Gly Leu Pro Val Gln Thr Leu Arg Pro Ser Tyr Gly Leu 245 250 255 gca gaa gca tcc ctg ctg gtc acc ac cca cag acc gaa aac cgc cca 816 Ala Glu Ala Ser Leu Leu Val Thr Thr Pro Gln Thr Glu Asn Arg Pro 260 265 270 ctg ate tcc tac tcc gac cgc gag gcc ttg gcc gaa aac cgc gtt gag 864 Leu He Ser Tyr Phe Asp Arg Glu Ala Leu Ala Glu Asn Arg Val Glu 25 275 280 285 ctt gta gaa aag ggc aat aac aac gct gct gct tcc gtc tcc aac ggc 912 Leu Val Glu Lys Gly Asn Asn Lys Ala Val Ala Phe Val Be Asn Gly 290 295 300 cag gtt gca gcc cca cag cag ctg gtc ate gtt gat ccc gaa acc gga 960 Gln Val Ala Ala Pro Gln Gln Leu Val He Val Asp Ser Glu Thr Gly 305 310 315 320 acc gag ctg gca gac ggc cag ate ggc gaa ate tgg acc fall ggc gaa 1008 Thr Glu Leu Wing Asp Gly Gln He Gly Glu He Trp Thr His Gly Glu 325 330 335 • aac act gct gca ggt tac etc gac cgc gag gaa gac acc gca gaa acc 1056 Asn Thr Ala Wing Gly Tyr Leu Asp Arg Glu Glu Asp Thr Wing Glu Thr 340 345 350 ttc cgc aac cgt ctg acc acc cgc ctg gaa gaa aac tcc cgc gca gaa 1104 Phe Arg Asn Arg Leu Thr Thr Arg Leu Glu Glu Asn Ser Arg Ala Glu 355 360 365 ggt gct gcc gac gac aac tac tgg atg gcc gcg acc ggt gcc etc gtc 1152 Gly Wing Wing Asp Asp Asn Tyr Trp Met Wing Thr Gly Asp Leu Gly Val 370 375 380 ate gta gac aac gag etc tac ate acc ggt cgt ctg aag gac etc ate 1200 He Val Asp Asn Glu Leu Tyr He Thr Gly Arg Leu Lys Asp Leu He 385 390 395 400 10 gtt gtc gca ggc cga aac falls tac cca cag gac ate gag tac acc gtc 1248 Val Val Ala Gly Arg Asn His Tyr Pro Gln Asp He Glu Tyr Thr Val 405 410 415 cag gct gcc tcc gca cae ate cgt gca gat tcc gtc gca gca tcc gca 1296 Gln Wing Wing Wing Wing His Wing Arg Wing Asp Ser Wing Wing Wing Phe Wing 420 425 430 gtc cca ggc gat gac att gaa aag etc ate ate ctg gca gaa cgc gac 1344 Val Pro Gly Asp Asp He Glu Lys Leu He He Leu Wing Glu Arg Asp 435 440 445 acc act gca aac gaac gcc gac gat gca gct gact gaa gca gca ate cgc 1392 Thr Thr Wing Asn Glu Wing Asp Asp Wing Wing Wing Glu Glu Wing He Arg 15 450 455 460 tcc gcc gtt ggc act gca ggt falls gtt gtt cca gaa gag ate cgt ate 1440 Ser Ala Val Gly Thr Ala His Gly Val Val Pro Glu Glu He Arg He 465 470 475 480 etc gca ect gac gag ate gcg cgt tcc tcc tcc gga aag ate gca cgc 1488 Leu Ala Pro Asp Glu He Wing Arg Being Ser Gly Lys He Wing Arg 485 490 495 cgc gtc aac cag cgc aac tac att cag gaa ca gct aac tagttctttg 1537 Arg Val Asn Gln Arg Asn Tyr He Gln Glu Gln Wing Asn 500 505 cagacaccgc agg 1550 20 < 210 > 12 < 211 > 509 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 12 Val Val Pro Pro Leu Tyr Asp Pro Asn Glu Pro Gly His Wing Asp His 1 5 10 15 Leu Asn Wing Val Phe Wing Asp Ser Glu Pro Val Val Val Leu Thr Asn 20 25 30 Ser Lys Ser Wing Gly Wing Val Arg Lys His Phe Ser Ser Leu Pro Wing 35 40 45 25 Wing Glu Arg Pro Arg He Leu Ser Val Asp Ser Leu Pro Asp Ser Leu aÉ¡Éfegfe ».A« 50 55 60 Wing Asp Ser Tyr Glu Asn Pro Met Leu Thr Glu Wing Gly Arg Arg Leu 65 70 75 80 Ala Ala Leu Arg Gln Ser Ala Pro He Asp Leu Thr Ala Phe Leu Gln 85 90 95 Tyr Thr Ser Gly Ser Thr Arg Thr Pro Wing Gly Val Val Leu Thr Asn 100 105 110 Arg Ser He Leu Thr Asn Val Leu Gln He Phe Ser Ala Ala Gln Leu 115 120 125 Lys Thr Pro Leu Arg Leu Val Ser Trp Leu Pro Leu His His Asp Met 130 135 140 Gly He He Leu Wing Wing Phe Val Thr Met Leu Gly Leu Asp Asn Glu 145 150 155 160 Phe Met Asn Pro Arg Asp Phe Val Gln Gln Pro Ser Arg Trp He Lys 165 170 175 Gln Leu Asn Arg Arg Glu Be Asp Val Asp Val Asn Val Tyr Thr Val 180 185 190 Val Pro Asn Phe Ala Leu Glu Leu Ala Ala Arg Tyr Ala Lys Pro Ala 195 200 205 Glu Gly Glu Thr Leu Asp Leu Ser Ala Leu Asp Ala He He He Gly 210 215 220 Ser Glu Pro Val Thr Glu Asn Ala Leu Thr Thr Phe Arg Glu Ala Phe 225 230 235 240 Glu Pro Tyr Gly Leu Pro Val Gln Thr Leu Arg Pro Ser Tyr Gly Leu 245 250 255 Wing Glu Wing Being Leu Leu Val Thr Thr Pro Gln Thr Glu Asn Arg Pro 260 265 270 Leu He Ser Tyr Phe Asp Arg Glu Wing Leu Wing Glu Asn Arg Val Glu 275 280 285 Leu Val Glu Lys Gly Asn Asn Lys Wing Val Wing Phe Val Ser Asn Gly 290 295 300 Gln Val Ala Ala Pro Gln Gln Leu Val He Val Asp Ser Glu Thr Gly 305 310 315 320 Thr Glu Leu Wing Asp Gly Gln He Gly Glu He Trp Thr His Gly Glu 325 330 335 Asn Thr Wing Wing Gly Tyr Leu Asp Arg Glu Glu Asp Thr Wing Glu Thr 340 345 350 Phe Arg Asn Arg Leu Thr Thr Arg Leu Glu Glu Asn Ser Arg Wing Glu 355 360 365 Gly Wing Wing Asp Asp Asn Tyr Trp Met Wing Thr Gly Asp Leu Gly Val 370 375 380 He Val Asp Asn Glu Leu Tyr He Thr Gly Arg Leu Lys Asp Leu He 385 390 395 400 Val Val Ala Gly Arg Asn His Tyr Pro Gln Asp He Glu Tyr Thr Val 405 410 415 Gln Ala Wing Wing His He Arg Wing Asp Ser Val Wing Wing Phe Wing 420 425 430 Val Pro Gly Asp Asp He Glu Lys Leu He He Leu Wing Glu Arg Asp 435 440 445 Thr Thr Wing Asn Glu Wing Asp Asp Wing Wing Wing Glu Glu Wing He Arg 450 455 460 Wing Val Gly Thr Wing His Gly Val Val Pro Glu Glu He Arg He 465 470 475 480 Leu Ala Pro Asp Glu He Ala Arg Being Ser Gly Lys He Ala Arg 485 490 495 Arg Val Asn Gln Arg Asn Tyr He Gln Glu Gln Ala Asn 500 505 I?,. . < 210 > 13 < 211 > 4953 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS • 5 < 222 > (101) .. (4930) < 223 > RXA02582 < 400 > 13 tggatgtcta ttctcctcag cctcgttttg gttgaggcgg atagttttaa tattttttta 60 agtttaagtt gtaatcgagc tgaaaggctg aggcctcaat atg gaa cag age caa 115 Met Glu Gln Ser Gln 1 5 tcg tcg gat cag aag atg acc gtt gaa cag gtt cgc acc tgg etc cgt 163 Being Ser Asp Gln Lys Met Thr Val Glu Gln Val Arg Thr Trp Leu Arg 10 15 20 gat tgg gtt gtc cgc acc acg ggt att ccg gtg gag gaa gtt acg gat 211 JQ Asp Trp Val Val Arg Thr Thr Gly He Pro Val Val Glu Val Thr Asp 25 30 35 gac aag gca atg gag acc ttt ggc ctt tcc tet cgc gat gtt gtt gtg 259 Asp Lys Wing Met Glu Thr Phe Gly Leu Ser Ser Arg Asp Val Val Val • 40 45 50 ttg tet ggt gag ctg gaa aac ctg ctg gac acc tcc ttg gat gcc acc 307 Leu Ser Gly Glu Leu Glu Asn Leu Leu Asp Thr Ser Leu Asp Wing Thr 55 60 65 ate gct tat gag tac cca acg ate cgt agt ttg gcg cag cgc ctt gtt 355 He Ala Tyr Glu Tyr Pro Thr He Arg Ser Leu Ala Gln Arg Leu Val 70 75 80 85 gag ggc gag ect cgt cgt gca cat acc cag cgt gaa ttg aat ttc tcc 403 15 Glu Gly Glu Pro Arg Arg Ala His Thr G ln Arg Glu Leu Asn Phe Ser 90 95 100 gcg gtg age gat tcc cca ggt tcc falls gat att gcg gtt gtc ggt atg 451 Wing Val Ser Asp Ser Pro Gly Ser His Asp He Wing Val Val Gly Met 105 110 115 gct gcg cgt tac cca ggc gct gag age ctg gag gat atg tgg aag cta 499 Wing Wing Arg Tyr Pro Gly Wing Glu Being Leu Glu Asp Met Trp Lys Leu 120 125 130 etc gtc gag ggc cgt gac ggt ate tcg gat cta att ggc cgt tgg 547 • Leu Val Glu Gly Arg Asp Gly He Be Asp Leu Pro He Gly Arg Trp 135 140 145 tet gag tat gca ggc gat gag gtt atg tet cgg aag atg gaa gag ttt 595 20 Ser Glu Tyr Wing Gly Asp Glu Val Met Ser Arg Lys Met Glu Glu Phe 150 155 160 165 tet acc ate ggt ggc tac ctg tea gat ate tet age ttt gat gcg gag 643 Ser Thr He Gly Gly Tyr Leu Ser Asp He Ser Ser Phe Asp Ala Glu 170 175 180 ttc ttt gt gt ctg tet ccg etc gag gcc gcc aac atg gat ect cag cag 691 Phe Phe Gly Leu Ser Pro Leu Glu Wing Wing Asn Met Asp Pro Gln Gln 185 190 195 cgt att ttg ctg gag cta acg tgg gag gct tg gag tac gct cgc ate 739 Arg He Leu Leu Glu Leu Thr Trp Glu Wing Leu Glu Tyr Wing Arg He 200 205 210 gca cca aac act ttg cgt ggc gaa gcc gtg ggc gtg ttc ata ggt tcc 787 25 Wing Pro Asn Thr Leu Arg Gly Glu Wing Val Gly Val Phe He Gly Ser ^ gjH¡g ^ 215 220 225 tcc aac aac a g aac a g gcc atg ate ggcctt ggcccc ggaatt ccccaa ggccaa ggaaaa ggccaa 835 Ser Asn Asn Asp Tyr Gly Met Met I Ala Ala Asp Pro Ala Glu Ala 230 235 240 245 cat ect tat gcg ctg act ggt act tet aaggtt ggccgg aatttt ggttcc aaaacc ccggcc 883 His Pro Tyr Wing Leu Thr Gly Thr Ser Wing Wing Val Wing Asn Arg 250 255 260 att aac tac gct ttc gat ttc cgc ggt ect tcc gtc aac gtg gat acc 931 He Asn Tyr Wing Phe Asp Phe Arg Gly Pro Ser Val Asn Val Asp Thr • 265 270 275 gca tgt tet tet tet ctg gta gcg gtt fall cag gct gtc cgt gcg ctg 979 Wing Cys Ser Ser Ser Leu Val Wing Val His Gln Wing Val Arg Ala Leu 280 285 290 cgt aat ggc gaa gcg gat fall gct ate gct ggt gga gtg aac att ttg 1027 Arg Asn Gly Glu Wing Asp His Wing Wing Wing Gly Gly Val Asn He Leu 295 300 305 gca tet cca ttt gtc here act gca ttc gct gag etc ggt gtg ate age 1075 Ala Ser Pro Phe Val Thr Thr Ala Phe Ala Glu Leu Gly Val He Ser 310 315 320 325 cca acc ggc aag ate drops gca ttc tet gat gat gcc ga t ggt ttc gtg 1123 10 Pro Thr Gly Lys He His Wing Phe Ser Asp Asp Wing Asp Gly Phe Val 330 335 340 cgt tcc gac ggc gcc gt gtc gtt gtg ctg aag cgc gtg gat gac gca 1171 Arg Ser Asp Gly Wing Gly Val Val Val Leu Lys Arg Val Asp Asp Ala • 345 350 355 ate cgc gac ggc gac aag ate ate ggt gtg ate aag ggt tet gca gtg 1219 He Arg Asp Gly Asp Lys He He Gly Val He Lys Gly Ser Wing Val 360 365 370 aac tcc gat ggt falls tcc aac gga ctg acc gct cca aac ect gac gca 1267 Asn Ser Asp Gly His Ser Asn Gly Leu Thr Wing Pro Asn Pro Asp Wing 375 380 385 cag gtt gat gtg ctg cag cgt gca tat gtt gac gct cag gtt gat ccc 1315 15 Gln Val Asp Val Leu Gln Arg Wing Tyr Val Asp Wing Gln Val Asp Pro 390 395 400 405 action acc gtg gat tac gtt gag gct fall ggc acc ggc acc ate ctg ggt 1363 Thr Thr Val Asp Tyr Val Glu Wing His Gly Thr Gly Thr He Leu Gly 410 415 420 gac ccc att gaa gca act gcc ctg ggt gct gtt ttg ggc tat ggc cgt 1411 Asp Pro He Glu Ala Thr Ala Leu Gly Ala Val Leu Gly Tyr Gly Arg 425 430 435 gac gca tcc acc cca act ctt ctg ggc tet gca aag tcc aac ttc ggc 1459 • Asp Wing Being Thr Pro Thr Leu Leu Gly Being Wing Lys Being Asn Phe Gly 440 445 450 drops act gag tea gct gcg ggt att gca ggt gtc ate aag gtg ctg ctt 1507 20 His Thr Glu Ser Ala Ala Gly He Ala Gly Val He Lys Val Leu Leu 455 460 465 gct ttg cag aac aag act ctg cca cca gtg aac ttt gca ggt cca 1555 Ala Leu Gln Asn Lys Thr Leu Pro Pro Thr Val Asn Phe Ala Gly Pro 470 475 480 485 aac cgc tac ate ttc gat gct gag cgt ttg gaa gtt gtg gaa gat 1603 Asn Arg Tyr He Asp Phe Asp Wing Glu Arg Leu Glu Val Val Glu Asp 490 495 500 cca cgt gaa tgg ccg gaa tac aac ggt fall gca gta gct ggt gtg tet 1651 Pro Arg Glu Trp Pro Glu Tyr Asn Gly His Wing Val Wing Gly Val Ser 505 510 515 gcg ttc ggg ttc ggt gga acc aac gcg falls gtg gtg ate tet gag tac 1699 25 Wing Phe Gly Phe Gly Gly Thr Asn Wing His Val Val He Ser Glu Tyr 520 525 530 aac gca gaa gac tac gaa acc cgt gcc ccg aag gag gcg ttg ctt ect 1747 Asn Ala Glu Asp Tyr Glu Thr Arg Ala Pro Lys Glu Ala Leu Leu Pro 535 540 545 gac cag gtt gcc ctg ccg gt g tet ggt falls ctg cca tcc agg cgt 1795 Asp Gln Gln Val Wing Leu Pro Val Ser Gly His Leu Pro Being Arg Arg 550 555 560 565 cga ca gca gct gct gac ttg gcg gac tcc tg gag ggc cgc aaa gat 1843, Arg Gln Ala Ala Ala Asp Leu Ala Asp Phe Leu Glu Gly Arg Lys Asp 570 575 580 tgc gac cta acc cca gta gcc cgc gcg ctg gca ggc cgc aat cat ggc 1891 Cys Asp Leu Thr Pro Val Ala Arg Ala Leu Ala Gly Arg Asn His Gly 585 590 595 cgc tcc cgc gca gtc gtg ctt gca age act ate gag gaa gcc gta aag 1939 Arg Ser Arg Ala Val Val Leu Ala Ser Thr He Glu Glu Ala Val Lys 600 605 610 cgc ctg cgc cag gtc gca gaa ggc aag gtc age gtc ggt ate tcc gca ggc 1987 Arg Leu Arg Gln Val Wing Glu Gly Lys Val Ser Val Gly He Ser Wing 615 620 625 gct gat tcc cca gcg gcc aac ggt ect gtg ttt gtg tac tcc ggt ttc 2035 10 Wing Asp Ser Pro Wing Wing Asn Gly Pro Val Phe Val Tyr Ser Gly Phe 630 635 640 645 gga tcc cg cgc falls etc atg ate aag gaa ttg tgc tea att tcg cca 2083 • Gly Ser Gln His Arg Leu Met He Lys Glu Leu Cys Ser He Ser Pro 650 655 660 cag ttc cgc gag cgc ate gaa gag etc gat gaa atg gtt aag ttc gag 2131 Gln Phe Arg Glu Arg He Glu Glu Leu Asp Glu Met Val Lys Phe Glu 665 670 675 tcc ggc tgg tcc ate atg aaa ctt gtt ttg gat gat gag caa act tac 2179 Ser Gly Trp Ser He Met Lys Leu Val Leu Asp Asp Glu Gln Thr Tyr 680 685 690 gac acc gag acc gcg cag gtt gtg ate acc gca ate cag ate gca ctg 2227 15 Asp Thr Glu Thr Ala Gln Val Val He Thr Ala He Gln He Ala Leu 695 700 705 act gac ctg ttg gca age ttc ggt gta aag cca gct gee gtc atg ggc 2275 Thr Asp Leu Leu Wing Being Phe Gly Val Lys Pro Ala Wing Val Met Gly 710 715 720 725 atg tcg atg ggt gag ate gct gcc gct tac gct gcc ggt gga etc age 2323 Met Ser Met Gly Glu He Ala Wing Wing Tyr Wing Wing Gly Gly Leu Ser 730 735 740 • gac cgc gat acc atg etc att gcc age falls cgt tcc cgc cta atg ggc 2371 Asp Arg Asp Thr Met Leu He Wing His Arg Being Arg Leu Met Gly 745 750 755 gag ggc gag aag tcc ctg gct gag g at cag ctg ggt gcc atg gct gtg 2419 20 Glu Gly Glu Lys Ser Leu Wing Glu Asp Gln Leu Gly Wing Met Wing Val 760 765 770 gtg gaa ttc gcc gcg gac ctg gat aag ttc ate gaa gaa aac ect 2467 Val Glu Phe Ala Wing Wing Asp Leu Asp Lys Phe He Glu Glu Asn Pro 775 780 785 gag tac aag ggc att gag ect gct tat gca ggc cca ggc atg act 2515 Glu Tyr Lys Gly He Glu Pro Wing Val Tyr Wing Gly Pro Gly Met Thr 790 795 800 805 acc gtg ggt gga ect cgc gac gcc gtg gtt cag ttc gta gag aag ctg 2563 Thr Val Gly Gly Pro Arg Asp Ala Val Val Gln Phe Val Glu Lys Leu 810 815 820 gaa tet gaa gac aag ttt gcc cgc ctg etc aac gtc aag ggc gct ggc 2611 25 Glu Ser Glu Asp Lys Phe Wing Arg Leu Leu Asn Val Lys Gly Wing Gly 825 830 835 falls acc tet gct gtg gaa cca ctt ctt ggt gag etc gct ggc gaa ate 2659 His Thr Ser Wing Val Glu Pro Leu Leu Gly Glu Leu Wing Gly Glu He 840 845 850 gct ggc ate gag cca ctt ccg ctg cag ate ccg ttg ttc age tet gtc 2707 Wing Gly He Glu Pro Leu Pro Leu Gln He Pro Leu Phe Ser Ser Val 855 860 865 gat cag ggt gtt acc tac cca gtt gga gca gtg gtc falls gac gcc gat 2755 Asp Gln Gly Val Thr Tyr Pro Val Gly Ala Val Val Asp Wing Asp 870 875 880 885 tac atg etc cgc tgt acc cgc cag tcc gtg tac ttc cag gac tcc acc 2803 Tyr Met Leu Arg Cys Thr Arg Gln Ser Val Tyr Phe Gln Asp Ser Thr 890 895 900 gaa gct gca ttc gct gca ggc falls aac acc ttg gtg gaa att tcc ccg 2851 Glu Ala Ala Phe Ala Ala Gly His Asn Thr Leu Val Glu He Ser Pro 905 910 915 aac cca gtt gca etc atg ggc atg atg aac acc gcg ttc acc gtg ggc 2899 Asn Pro Val Wing Leu Met Gly Met Met Asn Thr Wing Phe Thr Val Gly 920 925 930 aag ect gat gca cag ctg ctg ttc age ctg aag cga aaa gtc cca gag 2947 Lys Pro Asp Wing Gln Leu Leu Phe Ser Leu Lys Arg Lys Val Pro Glu 935 940 945 gca gaa tcc etc cgc gac ctt ctg gcg aag ctg tac gtc aac ggc gca 2995 Ala Glu Be Leu Arg Asp Leu Leu Wing Lys Leu Tyr Val Asn Gly Wing 950 955 960 965 aac gtt gat ttc tcc gcg ctg tac ggc gaa ggt gaa acc ate gat ccg 3043 Asn Val Asp Phe Ser Ala Leu Tyr Gly Glu G and Glu Thr He Asp Pro 970 975 980 cca falls a tgg aag falls cgc ttc tgg act tcc gca cgc cca 3091 Pro His He Thr Trp Lys His Gln Arg Phe Trp Thr Ser Wing Arg Pro 985 990 995 tcc tet ggc gcai tcc etc gat: ctg cc: g ggc ttc cgc gtg aat ctg cca 3139 Ser Ser Gly Alai Ser Leui Asp > Leu Pi: o Gly Phe Arg Val Asn Leu Pro 100C) 1005 1010 aac aac act • gt? Gc? F ttt: tcc: acc gca gcc gala ct: g gca cc: ccaa tt: cccc ggccaa 3187 Asn Asn Thi - Val . Alai Phe: Ser - Thr Al .a Al .a Gl .u L Lee ¡uu; Aillaa EP > Seroir Sera AAllaa 101E 1020 11C0 12255 gtg gcai ate: atg [gaai gcai ge: c gcc atg gct gt: c aaiccec cc: ccaa? gjggtt tt: cccc ttcccc 3235 Val Alai Hei Met. Glui Alai Al .a Ala Met Al .a Val 1T 'hhrr? P' rroo GG 51lyy £ S 1err SSerr 103C) 1035 11C0 14400 1100445 gtc gac gca gtg gac gag cgc gac atg ctg cca cca age ggc gaa ate 3283 Val Asp Ala Val Asp Glu Arg Asp Met Leu Pro Pro Ser Gly Glu He 1050 1055 1060 acc acc gtg act cgc tcc ggc ggggtt ttttgg aaggee ccttgg ttcccc ggttaa tac 3331 Thr Thr He Val Thr Arg Ser Leu Gly GGllyy LLeeuu SSeerr LLeeuu SSerr VVaall Tyr 1065 1070 1075 aag att gag gga acc acc age act ctt gtc gcc gaa ggt ttc gca gcc 3379 Lys He Glu Gly Thr Thr Ser Thr Leu Val Ala Glu Gly Phe Wing Wing 1080 1085 1090 aac cca gga tcc gcc gca gca tet tcc gac ggt cca gcc tac gac 3427 Asn Pro Gly Phe Ala Wing Wing Being Ser Phe Asp Gly Pro Gly Tyr Asp 1095 1100 1105 gga ttc aac acc gat tac age gac cag cca gac ect cgc tcc gac ctg 3475 Gly Phe Asn Thr Asp Tyr Ser Asp Gln Pro Asp Pro Arg As Asp Leu 1110 1115 1120 1125 ect ttg gac ate gaa gca gtc cgc tgg gac cca gcg acc gaa acc gtc 3523 Pro Leu Asp He Glu Wing Val Arg Trp Asp Pro Wing Thr Glu Thr Val _i__í ____ ^^^ g ^ g 1130 1135 1140 gaa gag cgc atg cgc gcc ate gtc tcc gaa gca atg ggc tac gac gtg 3571 Glu Glu Arg Met Arg Ala He Val Ser Glu Ala Met Gly Tyr Asp Val 1145 1150 1155 gat gac etc cca cgc gaa etc cca ctg att gac etc ggc etc gac tcc 3619 Asp Asp Leu Pro Arg Glu Leu Pro Leu As As Leu Gly Leu Asp Ser 1160 1165 1170 etc. atg ggc atg cgc ate aaa aac cgc ate gaa aat gac ttc cag ate 3667 Leu Met Gly Met Arg He Lys Asn Arg He Glu Asn Asp Phe Gln He 1175 1180 1185 cca cca etc cag gtc ca gcg etc cgc gat gca gcc ccc gc gac gtg 3715 Pro Pro Leu Gln Val Gln Ala Leu Arg Asp Wing Ser Val Wing Asp Val 1190 1195 1200 1205 gta ate atg gtg gaa aac atg gtc gct ggc cgc tcc tet gag acg ctt 3763 Val He Met Val Glu Asn Met Val Wing Gly Arg Ser Ser Glu Thr Leu 1210 1215 1220 gtc gac gcc acc ccg cag gtg cca gct gag gca gca ggg gag gct caa 3811 Val Asp Wing Thr Pro Gln Val Pro Wing Glu Wing Wing Gly Glu Wing Gln 1225 1230 1235 gct gct gag tet tet gc tcg gcg gac gac gtg cag gcc gtt ggc gtt 3859 Wing Wing Glu Being Wing Being Gly Glu Asp Val Gln Gly Val Gly Val 1240 1245 1250 gca ccg cga gat gcg tcg gaa cgc atg gtc ttt ggt act tgg gca ggc 3907 Wing Pro Arg Asp Wing Ser Glu Arg Met Val Phe Gly Thr Trp Wing Gly 1255 1260 1265 ctg act ggc gct gcg gca gct ggc gtg acc age aag ttg cca cag ate 3955 Leu Thr Gly Wing Wing Wing Wing Gly Val Thr Ser Lys Leu Pro Gln He 1270 1275 1280 1285 gat gtc gat act gca acc gca att gcc gag cgc etc acc gag cgt tcc 4003 Asp Val Asp Thr Ala Thr Ala He Wing Glu Arg Leu Thr Glu Arg Ser 1290 1295 1300 gga att gaa ate age act gaa cag gtg ttg gct gca gaa acc etc gaa 4051 Gly He Glu He Be Thr Glu Gln Val Leu Ala Wing Glu Thr Leu Glu 1305 1310 1315 cca ctg tet gac ctg gtg cgt gaa ggc etc gaa act gaa gtt cag ggc • 4099 Pro Leu Ser Asp Leu Val Arg Glu Gly Leu Glu Thr Glu Val Gln Gly 1320 1325 1330 aac att cgt gtg ctg cgt gga cgt gca gaa ggc tcc acc aag ect gca '4147 Asn He Arg Val Leu Arg Gly Arg Wing Glu Gly Ser Thr Lys Pro Wing 1335 1340 1345 gtg ttc atg ttc falls cca gct ggc ggt tet tcc gtg gtc tac cac cca '4195 Val Phe Met Phe His Pro Wing Gly Gly Ser Val Val Tyr Gln Pro 135C) 135Í 136C) 1365 cta atg cgt cgt ctg ect gaa gat gtc ect gtc tat ggc gtt gag cgt -4243 Leu Met Arg Arg Leu Pro Glu Asp Val Pro Val Tyr Gly Val Glu Arg 1370 1375 1380 ctg gaa ggc gat etc gct gac cgc gcg gca gca tat gtt gat gac ate • 4291 Leu Glu Gly Asp Leu Wing Asp Arg Wing Wing Wing Tyr Val Asp Asp He 1385 1390 1395 aag aag tac tc gc tc gc tc cc gta gtt ttg ggt ggc tgg age ttc • 4339 L Lyyss L Lyyss TTyyrr S Seerr A Asspp G Gllyy Phe Pro Val Val Leu Gly Gly Trp Ser Phe 11440000 1405 1410 ggggcc ggggtt ggcccc ggtttt ggcccc ttttcc gag gtt gcc falls ca gt ctg gtt gcc tcc gat < 4387 G Gllyy G Gllyy AAllaa V Vaall Allaa P Phhee Glu Val Ala His Gln Leu Val Gly Ser Asp 11441155 1420 1425 ggtttt ggaagg ggttaa ggcctt aacccc ggttgg gcg ttg ctg gat act gtg cag ect tea aac 4435 V Vaall G Glluu VVaall A Allaa T Thhrr V Vaall Wing Leu Leu Asp Thr Val Gln Pro Ser Asn 1430 1435 1440 1445 cca gca cca gat acc gct gag gaa act cgt gca cgc tgg act cgc tac 4483 Pro Ala Pro Asp Thr Ala Glu Glu Thr Arg Wing Arg Trp Thr Arg Tyr 1450 1455 1400 gcg gac tcc gcc aag aag a cc acc gcc ctt gat tcc gag gta ect ttt 4531 Wing Asp Phe Wing Lys Lys Thr Tyr Gly Leu Asp Phe Glu Val Pro Phe 1465 1470 1475 gaa ate ttg gac acc ate ggt gaa gac gga atg ctg tcc atg atg acc 4579 Glu He Leu Asp Tnr He Gly Glu Asp Gly Met Leu Ser Met Met Thr 1480 1485 1490 gac ttc ctg gcc aac acc gac gcc tcc gag cae gga ttg tcc gca ggt 4627 Asp Phe Leu Wing Asn Thr Asp Wing Ser Glu His Gly Leu Wing Wing Gly 1495 1500 1505 gtg ctt gaa falls cag cgc gct tet ttt gtg gac aac cgc ate ctg gct 4675 Val Leu Glu His Gln Arg Ala Ser Phe Val Asp Asn Arg He Leu Ala 1510 1515 1520 1525 aaa ctt aat ttt gca gac tgg gcc aac gtt gaa gcc ect gtc ate ctg 4723 Lys Leu Asn Phe Wing Asp Trp Wing Asn Val Glu Wing Pro Val He Leu 1530 1 535 1540 tcc cgc gcg gaa cgc atg cat gat gga gct ate gaa ctt gaa cca aac 4771 10 Phe Arg Wing Glu Arg Met His Asp Gly Wing He Glu Leu Glu Pro Asn 1545 1550 1555 tat gcc aag att gat gga cat gga ggg tgg tcc gga att gtc aac gat 4819 Tyr Wing Lys He Asp Gln Asp Gly Gly Trp Ser Gly He Val Asn Asp • 1560 1565 1570 ttg gaa att gtt cag ctg aat ggt gac falls ctg gca gtt gtc gat gaa 4867 Leu Glu He Val Gln Leu Asn Gly Asp His Leu Ala Val Val Asp Glu 1575 1580 1585 cca gaa ate ggc here gtc gga gct cat ttg agt cgc cgc att gat gag 4915 Pro Glu He Gly Thr Val Gly Wing His Leu Ser Arg Arg He Asp Glu 1590 1595 1600 1605 15 att tet cgg aag aat tagtaacgga gagctgacgg aag 4953 He Ser Arg Lys Asn 1610 < 210 > 14 < 211 > 1610 < 212 > PRT < 213 > Corynebacterium glutamicum • < 400 > 14 Met Glu Gln Ser Gln Ser As Asp Gln Lys Met Thr Val Glu Gln Val 1 5 10 15 2Q Arg Thr Trp Leu Arg Asp Trp Val Val Arg Thr Thr Gly He Pro Val 20 25 30 Glu Glu Val Thr Asp Asp Lys Ala Met Glu Thr Phe Gly Leu Ser Ser 35 40 45 Arg Asp Val Val Val Leu Ser Gly Glu Leu Glu Asn Leu Leu Asp Thr 50 55 60 Ser Leu Asp Wing Thr He Wing Tyr Glu Tyr Pro Thr He Arg Ser Leu 65 70 75 80 Wing Gln Arg Leu Val Glu Gly Glu Pro Arg Arg Ala His Thr Gln Arg 85 90 95 Glu Leu Asn Phe Ser Wing Val Ser Asp Ser Pro Gly Ser His Asp He 100 105 110 25 Wing Val Val Gly Met Wing Wing Arg Tyr Pro Gly Wing Glu Ser Leu Glu 115 120 125 Asp Met Trp Lys Leu Leu Val Glu Gly Arg Asp Gly He Ser Asp Leu 130 135 140 Pro He Gly Arg Trp Ser Glu Tyr Ala Gly Asp Glu Val Met Ser Arg 145 150 155 160 Lys Met Glu Glu Phe Ser Thr He Gly Gly Tyr Leu Ser Asp He Ser 165 170 175 Ser Phe Asp Wing Glu Phe Phe Gly Leu Ser Pro Leu Glu Wing Ala Asn • 180 185 190 Met Asp Pro Gln Gln Arg He Leu Leu Glu Leu Thr Trp Glu Wing Leu 195 200 205 Glu Tyr Wing Arg He Wing Pro Asn Thr Leu Arg Gly Glu Wing Val Gly 210 215 220 Val Phe He Gly Ser Ser Asn Asn Asp Tyr Gly Met Met He Ala Wing 225 230 235 240 Asp Pro Wing Glu Wing His Pro Tyr Wing Leu Thr Gly Thr Ser Wing 245 250 255 He Val Wing Asn Arg He Asn Tyr Wing Phe Asp Phe Arg Gly Pro Ser 260 265 270 Val Asn Val Asp Thr Wing Cys Ser Ser Leu Val Ala Val His Gln 10 275 280 285 Wing Val Arg Wing Leu Arg Asn Gly Glu Wing Asp His Wing Wing Wing Gly 290 295 300 Gly Val Asn He Leu Wing Pro Pro Phe Val Thr Thr Wing Phe Wing Glu 305 310 315 320 Leu Gly Val He Ser Pro Thr Gly Lys He His Wing Phe Ser Asp Asp 325 330 335 Wing Asp Gly Phe Val Arg Ser Asp Gly Wing Gly Val Val Val Leu Lys 340 345 350 Arg Val Asp Asp Wing He Arg Asp Gly Asp Lys He He Gly Val He 355 360 365 Lys Gly Ser Ala Val Asn Ser Asp Gly His Ser Asn Gly Leu Thr Ala 15 370 375 380 Pro Asn Pro Asp Ala Gln Val Asp Val Leu Gln Arg Ala Tyr Val Asp 385 390 395 400 Wing Gln Val Asp Pro Thr Thr Val Asp Tyr Val Glu Wing His Gly Thr 405 410 415 Gly Thr He Leu Gly Asp Pro He Glu Wing Thr Wing Leu Gly Wing Val 420 425 430 Leu Gly Tyr Gly Arg Asp Wing Being Thr Pro Thr Leu Leu Gly Ser Wing 435 440 445 Lys Ser Asn Phe Gly His Thr Glu Be Wing Wing Gly He Wing Wing Val 450 455 460 He Lys Val Leu Leu Wing Leu Gln Asn Lys Thr Leu Pro Pro Thr Val 20 465 470 475 480 Asn Phe Wing Gly Pro Asn Arg Tyr He Asp Phe Asp Wing Glu Arg Leu 485 490 495 Glu Val Val Glu Asp Pro Arg Glu Trp Pro Glu Tyr Asn Gly His Wing 500 505 510 Val Wing Gly Val Ser Wing Phe Gly Phe Gly Gly Thr Asn Ala His Val 515 520 525 Val He Ser Glu Tyr Asn Wing Glu Asp Tyr Glu Thr Arg Wing Pro Lys 530 535 540 Glu Wing Leu Leu Pro Asp Gln Gln Val Wing Leu Pro Val Ser Gly His 545 550 555 560 Leu Pro Being Arg Arg Arg Gln Wing Wing Wing Asp Leu Wing Asp Phe Leu 25 565 570 575 Glu Gly Arg Lys Asp Cys Asp Leu Thr Pro Val Wing Arg Wing Leu Wing 580 585 590 Gly Arg Asn His Gly Arg Ser Arg Wing Val Val Leu Wing Ser Thr He 595 600 605 Glu Glu Wing Val Lys Arg Leu Arg Gln Val Wing Glu Gly Lys Val Ser 610 615 620 Val Gly He Wing Wing Wing Asp Ser Pro Wing Wing Asn Gly Pro Val Phe 625 630 635 640 • Val Tyr Ser Gly Phe Gly Ser Gln His Arg Leu Met He Lys Glu Leu 645 650 655 Cys Ser He Ser Pro Gln Phe Arg Glu Arg He Glu Glu Leu Asp Glu 660 665 670 Met Val Lys Phe Glu Ser Gly Trp Ser Met Met Lys Leu Val Leu Asp 675 680 685 Asp Glu Gln Thr Tyr Asp Thr Glu Thr Ala Gln Val Val He Thr Wing 690 695 700 He Gln He Ala Leu Thr Asp Leu Leu Wing Wing Phe Gly Val Lys Pro 705 710 715 720 Wing Wing Val Met Gly Met Ser Wing Gly Glu Wing Wing Wing Tyr Wing 725 730 735 10 Wing Gly Gly Leu Ser Asp Arg Asp Thr Met Leu He Wing His Arg 740 745 750 Ser Arg Leu Met Gly Glu Glu Glu Lys Ser Leu Wing Glu Asp Gln Leu 755 760 765 • Gly Wing Met Wing Val Val Glu Phe Wing Wing Wing Asp Leu Asp Lys Phe 770 775 780 He Glu Glu Asn Pro Glu Tyr Lys Gly He Glu Pro Wing Val Tyr Wing 785 790 795 800 Gly Pro Gly Met Thr Thr Val Gly Gly Pro Arg Asp Ala Val Val Gln 805 810 815 Phe Val Glu Lys Leu Glu Ser Glu Asp Lys Phe Ala Arg Leu Leu Asn 820 825 830 15 Val Lys Gly Wing Gly His Thr Ser Wing Val Glu Pro Leu Leu Gly Glu 835 840 845 Leu Wing Gly Glu He Wing Gly He Glu Pro Leu Pro Leu Gln He Pro 850 855 860 Leu Phe Ser Val Ser Valp Gln Gly Val Thr Tyr Pro Val Gly Wing Val 865 870 875 880 Val His Asp Wing Asp Tyr Met Leu Arg Cys Thr Arg Gln Ser Val Tyr 885 890 895 Phe Gln Asp Ser Thr Glu Wing Wing Phe Wing Wing Gly His Asn Thr Leu • 900 905 910 Val Glu He Ser Pro Asn Pro Val Wing Leu Met Gly Met Met Asn Thr 915 920 925 20 Wing Phe Thr Val Gly Lys Pro Asp Ala Gln Leu Leu Phe Ser Leu Lys 930 935 940 Arg Lys Val Pro Glu Ala Glu Ser Leu Arg Asp Leu Leu Wing Lys Leu 945 950 955 960 Tyr Val Asn Gly Wing Asn Val Asp Phe Ser Wing Leu Tyr Gly Glu Gly 965 970 975 Glu Thr He Asp Pro Pro His He Thr Trp Lys His Gln Arg Phe Trp 980 985 990 Thr Ser Wing Arg Pro Ser Ser Gly Wing Ser Leu Asp Leu Pro Gly Phe 995 1000 1005 Arg Val Asn Leu Pro Asn Asn Thr Val Wing Phe Ser Thr Wing Wing Glu 1010 1015 1020 25 Leu Wing Pro Ser Wing Val Wing He Met Glu Wing Ala Wing Met Wing Val 1025 1030 1035 1040 Thr Pro Gly Ser Ser Val Asp Ala Val Asp Glu Arg Asp Met Leu Pro 1045 1050 1055 Pro Ser Gly Glu He Thr Thr He Val Thr Arg Ser Leu Gly Gly Leu 1060 1065 1070 Ser Leu Ser Val Tyr Lys He Glu Gly Thr Thr Ser Thr Leu Val Ala 1075 1080 1085 Glu Gly Phe Ala Ala Asn Pro Gly Phe Ala Ala Ala Ser Ser Phe Asp 1090 1095 1100 Gly Pro Gly Tyr Asp Gly Phe Asn Thr Asp Tyr Ser Asp Gln Pro Asp 1105 1110 1115 1120 Pro Arg Ser Asp Leu Pro Leu Asp He Glu Wing Val Arg Trp Asp Pro 1125 1130 1135 Wing Thr Glu Thr Val Glu Glu Arg Met Arg Ala He Val Ser Glu Ala 1140 1145 1150 Met Gly Tyr Asp Val Asp Asp Leu Pro Arg Glu Leu Pro Leu He Asp 1155 1160 1165 Leu Gly Leu Asp Being Leu Met Gly Met Arg He Lys Asn Arg He Glu 1170 1175 1180 Asn Asp Phe Gln He Pro Pro Leu Gln Val Gln Wing Leu Arg Asp Wing 1185 1190 1195 1200 Ser Val Wing Asp Val Val He Met Val Glu Asn Met Val Wing Gly Arg 1205 1210 1215 Ser Ser Glu Thr Leu Val Asp Wing Thr Pro Gln Val Pro Wing Glu Ala 1220 1225 1230 Wing Gly Glu Wing Gln Wing Wing Glu Being Ser Wing Being Gly Glu Asp Val 1235 1240 1245 Gln Gly Val Gly Val Ala Pro Arg Asp Ala Ser Glu Arg Met Val Phe 1250 1255 1260 Gly Thr Trp Wing Gly Leu Thr Gly Wing Wing Wing Wing Gly Val Thr Ser 1265 1270 1275 1280 Lys Leu Pro Gln He Asp Val Asp Thr Wing Thr Wing Wing Glu Arg 1285 1290 1295 1295 Leu Thr Glu Arg Ser Gly He Glu I Ser Thr Glu Gln Val Leu Ala 1300 1305 1310 Wing Glu Thr Leu Glu Pro Leu Ser Asp Leu Val Arg Glu Gly Leu Glu 1315 1320 1325 Thr Glu Val Gln Gly Asn He Arg Val Leu Arg Gly Arg Ala Glu Gly 1330 1335 1340 Ser Thr Lys Pro Wing Val Phe Met Phe His Pro Wing Gly Gly Ser Ser 1345 1350 1355 1360 Val Val Tyr Gln Pro Leu Met Arg Arg Leu Pro Glu Asp Val Pro Val 1365 1370 1375 Tyr Gly Val Glu Arg Leu Glu Gly Asp Leu Ala Asp Arg Ala Ala Ala 1380 1385 1390 Tyr Val Asp Asp He Lys Lys Tyr As Asp Gly Phe Pro Val Val Leu 1395 1400 1405 Gly Gly Trp Ser Phe Gly Gly Wing Val Wing Phe Glu Val Wing His Gln 1410 1415 1420 Leu Val Gly As Asp Val Glu Val Wing Thr Val Wing Leu Leu Asp Thr 1425 1430 1435 1440 Val Gln Pro Ser Asn Pro Wing Pro Asp Thr Wing Glu Glu Thr Arg Wing 1445 1450 1455 Arg Trp Thr Arg Tyr Wing Asp Phe Ala Lys Lys Thr Tyr Gly Leu Asp 1460 1465 1470 Phe Glu Val Pro Phe Glu He Leu Asp Thr He Gly Glu Asp Gly Met 1475 1480 1485 Leu Ser Met Met Thr Asp Phe Leu Wing Asn Thr Asp Wing Ser Glu His 1490 1495 1500 Gly Leu Ser Wing Gly Val Leu Glu His Gln Arg Ala Ser Phe Val Asp 1505 1510 1515 1520 Asn Arg He Leu Wing Lys Leu Asn Phe Wing Asp Trp Wing Asn Val Glu 1525 1530 1535 Wing Pro Val He Leu Phe Arg Wing Glu Arg Met His Asp Gly Wing He 1540 1545 1550 Glu Leu Glu Pro Asn Tyr Wing Lys He Asp Gln Asp Gly Gly Trp Ser 1555 1560 1565 Gly He Val Asn Asp Leu Glu He Val Gln Leu Asn Gly Asp His Leu 1570 1575 1580 Wing Val Val Asp Glu Pro Glu He Gly Thr Val Gly Ala His Leu Ser 1585 1590 1595 1600 Arg Arg He Asp Glu He Be Arg Lys Asn 1605 1610 < 210 > 15 < 211 > 540 < 212 > DNA 10 < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS • < 222 > (101) .. (517) < 223 > RXA01138 < 400 > 15 ettattcaag tttttggaaa gataattaac tatgacttta aaaacagtaa acggaacgca 60 gctgcgagac actgtcggat cgttcccttc aggtgtcacg gtg gtc acc act acc 115 Val Val Thr Thr Thr 5 15 gat ggg gaa gtg gac falls ggg ttg act gtg agt gcg ttc gtg tcc ttg 163 Asp Gly Glu Val Asp His Gly Leu Thr Val Ser Wing Phe Val Ser Leu 10 15 20 tcg ttg gag ect gcc atg gtg ttg gtg agt ate gat aag aaa tea age 211 Be Leu Glu Pro Wing Met Val Leu Val Ser He Asp Lys Lys Ser Ser 25 30 35 gtt gtg ccg ttt tg gag ggt tea cca gtt gct gtg tet gtg tta 259 Val Val Pro Phe Leu Glu Gln Gly Ser Pro Val Wing Val Ser Val Leu 40 45 50 • tcg gaa gag cag age gat ttg gcc ate here ttt ggc cgt cat ctg gaa 307 Ser Glu Glu Gln Ser Asp Leu Wing He Thr Phe Gly Arg His Leu Glu 55 60 65 20 aac aaa ttc gac ggc gtt tcc att aag cgt tea aac agg gca gcg 355 Asn Lys Phe Asp Gly Val Ser He Lys Arg Ser Thr Asn Arg Ala Wing 70 75 80 85 gtc ttg gaa ggt gcg tea gca tgg ttg agt ggc gct gtg gtg gat aaa 403 Val Leu Glu Gly Wing Ser Wing Trp Leu Ser Gly Wing Val Val Asp Lys 90 95 100 tac cca ggt gga gat fall ttt att ate acc att gcc gtg gaa gag tgt 451 Tyr Pro Gly Gly Asp His Phe He He Thr He Wing Val Glu Glu Cys 105 110 115 gct falls gac gag gag caa aag cca ctt ctt tac falls cgt ggc agg ctt 499 Ala His Asp Glu Glu Gln Lys Pro Leu Leu Tyr His Arg Gly Arg Leu 120 125 130 25 ttt cag tgg caa gaa gat taatteteca ccccttcatt ttc 540 tfcí.A.jt. *? J J B »£ Phe Gln Trp Gln Glu Asp 135 < 210 > 16 < 211 > 139 < 212 > PRT < 213 > Corynebacterium gluta icum < 400 > 16 • Val Val Thr Thr Thr Asp Gly Val Val Asp His Gly Leu Thr Val Ser 1 5 10 15 Wing Phe Val Ser Leu Ser Leu Glu Pro Wing Met Val Val Leu Val Ser He 20 25 30 Asp Lys Lys Ser Val Val Pro Pro Phe Leu Glu Gln Gly Ser Pro Val 35 40 45 Wing Val Ser Val Leu Ser Glu Glu Gln Ser Asp Leu Wing He Thr Phe 50 55 60 Gly Arg His Leu Glu Asn Lys Phe Asp Gly Val Ser He Lys Arg Ser 65 70 75 80 Thr Asn Arg Ala Ala Val Leu Glu Gly Ala Be Ala Trp Leu Ser Gly 10 85 90 95 Wing Val Val Asp Lys Tyr Pro Gly Gly Asp His Phe He He Thr He 100 105 110 Wing Val Glu Glu Cys Ala His Asp Glu Glu Gln Lys Pro Leu Leu Tyr 115 120 125 His Arg Gly Arg Leu Phe Gln Trp Gln Glu Asp 130 135 < 210 > 17 < 211 > 756 < 212 > DNA < 213 > Corynebacterium gluta icum 15 < 220 > < 221 > CDS < 222 > (101) .. (733) < 223 > RXA01980 < 400 > 17 aggategtac caaataaggc aataaactct ttttactttt cctcaacttc ctgaaaagtc 60 gccgccctag aattcactaa gtttccgata tctttaaccc atg cag ate att gat 115 Met Gln He He Asp 1 5 etc tet cat gcg ttc gcg ccc gga caca ccc falls tac ect ggg gat cca 163 20 Leu Ser His Wing Phe Wing Pro Gly Gln Pro His Tyr Pro Gly Asp Pro 10 15 20 gat caa gaa att aag acg gtc tcc acg att gaa aac gat ggc ttt tta 211 Asp Gln Glu He Lys Thr Val Ser Thr He Glu Asn Asp Gly Phe Leu 25 30 35 atg cat ca ta ta aga ctt gtt ggt ccc tgg gga ac g cat gta gat gca 259 Met His Gln Tyr Arg Leu Val Gly Pro Trp Gly Thr His Val Asp Wing 40 45 50 ect gca cat ttc gat cca ca ggt cgg acg ctt gat cag ate ect gtg 307 Pro Ala His Phe Asp Pro Gln Gly Arg Thr Leu Asp Gln He Pro Val 55 60 65 gag gaa acg cat tta ccc ctt tat tgc ctg agg ttt tet cgc ccc gat 355 25 Glu Glu Thr His Leu Pro Leu Tyr Cys Leu Arg Phe Ser Arg Pro Asp 70 75 80 85 cta tgt act gct gat ata gaa gcg ttt gaa cat here falls ggg aaa 403 Leu Cys Thr Wing Wing Asp He Glu Wing Phe Glu His Thr His Gly Lys 90 95 100 ate gaga cca gga tcc ttc gtc gca etc fall act gga tgg gaa tgg ggt 451 He Glu Pro Gly Ser Phe Val Ala Leu His Thr Gly Trp Glu Trp Gly 105 110 115 aaa ca ggg ate gca ccc ggc tgg tet ate gag gct tta gaa ate etc 499 • 5 Lys Gln Gly He Wing Pro Gly Trp Ser He Glu Wing Leu Glu He Leu 120 125 130 cat gcc cgt gga gtc att gcc att ggc falls gat ctt ccc gat gat gat 547 His Wing Arg Gly Val He Wing He Gly His Asp Leu Pro Asp Thr Asp 135 140 145 ect tea ctg gag gca cag cgc tgg tgg cgg cgt gac cat tgg cag 595 Pro Ser Leu Glu Wing Gln Arg Trp Trp Leu Cys Arg Asp His Trp Gln 150 155 160 165 att gaa aac etc acc aat ttg gac aag gtt ect gca acg ggt gcg atg 643 He Glu Asn Leu Thr Asn Leu Asp Lys Val Pro Wing Thr Gly Wing Met 170 175 180 att gct tgt ect tgg cca gtt cca aaa gat ggt gct agt ttc cca gtg 691 JQ He Ala Cys Pro Trp Pro Val Pro Lys Asp Gly Wing Ser Phe Pro Val 185 190 195 cgt cca att gct etc gtc cca gag drops cta tcc ect act cgc 733 Arg Pro He Wing Leu Val Pro Glu His Leu Ser Pro Thr Arg • 200 205 210 taaagcgaac ggcagcacct tet 756 < 210 > 18 < 211 > 211 < 212 > PRT < 213 > Corynebacterium glutamicum 15 < 40? D > 18 Met Gln He He Asp Leu Ser His Wing Phe Wing Pro Gly Gln Pro His 1 5 10 15 Tyr Pro Gly Asp Pro Asp Gln Glu He Lys Thr Val Ser Thr He Glu 20 25 30 Asn Asp Gly Phe Leu Met His Gln Tyr Arg Leu Val Gly Pro Trp Gly 35 40 45 Thr His Val Asp Wing Pro Wing His Phe Asp Pro Gln Gly Arg Thr Leu 50 55 60 Asp Gln He Pro Val Glu Glu Thr His Leu Pro Leu Tyr Cys Leu Arg 65 70 75 80 Phe Ser Arg Pro Asp Leu Cys Thr Wing Wing Asp He Glu Wing Phe Glu 20 85 90 95 His Thr His Gly Lys He Glu Pro Gly Ser Phe Val Wing Leu His Thr 100 105 110 Gly Trp Glu Trp Gly Lys Gln Gly He Wing Pro Gly Trp Ser He Glu 115 120 125 Wing Leu Glu He Leu His Wing Arg Gly Val He Wing He Gly His Asp 130 135 140 Leu Pro Asp Thr Asp Pro Ser Leu Glu Wing Gln Arg Trp Trp Leu Cys 145 150 155 160 Arg Asp His Trp Gln He Glu Asn Leu Thr Asn Leu Asp Lys Val Pro 165 170 175 Wing Thr Gly Wing Met He Wing Cys Pro Pro Trp Pro Val Pro Lys Asp Gly 25 180 185 190 Sip üii tB Wing Being Phe Pro Val Arg Pro He Wing Leu Val Pro Glu His Leu Ser 195 200 205 Pro Thr Arg 210 < 210 > 19 < 211 > 1830 < 212 > DNA < 213 > Corynebacterium glutamicum • < 220 > < 221 > CDS < 222 > (101) .. (1807) < 223 > RXN01007 < 400 > 19 tctgaaccaa tataccgatc agtctaaaag tgtgttaagt tctggaacat aaattagctg 60 acacgtaaag taacttaaag attcactgga ggtaagccta gtg ttt aaa aag falls 115 Val Phe Lys Lys His 1 5 10 aga falls ggt etc ggc tcc ccc gaa acc aaa cca cgc tea ata acc cgc 163 Arg His Gly Leu Gly Ser Pro Glu Thr Lys Pro Arg Ser He Thr Arg 10 15 20 cgg ttt ttc acc gcg gcc gcc gct acg ctg gca gga ttg gca gtc ctg 211 • Arg Phe Phe Thr Wing Wing Wing Thr Leu Wing Gly Leu Wing Val Leu 25 30 35 tcc ggc tgc here gca ca ccc tea ca gca gaa gac aac acg etc act 259 Ser Gly Cys Thr Wing Gln Pro Ser Gln Wing Glu Asp Asn Thr Leu Thr 40 45 50 tac tta gag cca cag ttc ttc cgc acc ctg tac cca cca tea gcg ggc 307 Tyr Leu Glu Pro Gln Phe Phe Arg Thr Leu Tyr Pro Pro Ser Wing Gly 55 60 65 jg ttt tac ccc aac ggc agt gtg gtg aac aac att gca gac cgc ttg etc 355 Phe Tyr Pro Asn Gly Ser Val Val Asn Asn He Wing Asp Arg Leu Leu 70 75 80 85 tac cag gat ect gaa acc ttg gaa etc aag ccg tgg ate gcc acc gaa 403 Tyr Gln Asp Pro Glu Thr Leu Glu Leu Lys Pro Trp He Wing Thr Glu 90 95 100 etc cca gaa gta aac gaa gac gcc acg gaa tttttt aacccc ttttcc aaaacc aattee ccggcc 451 Leu Pro Glu Val Asn Glu Asp Ala Thr Glu Phe Thr Phe Asn He Arg 105 110 115 • acc gat gtc acc acc tcc gat ggc acc ccg ccttgg aaccgg ggcctt ggaaaa aaaacc ggttgg 499 Thr Asp Val Thr Tyr Ser Asp Gly Thr Pro Leu Thr Wing Glu Asn Val 120 125 130 2Q gtg aaa aac ttc gat etc tat ggc etc ggc gat gat gat cga cgc etc 547 Val Lys Asn Phe Asp Leu Tyr Gly Leu Gly Asp Gln Asp Arg Arg Leu 135 140 145 acc ate tet gag cag ate acc acac tac gac cae ggc gaa gta gta gat 595 Thr He Ser Glu Gln He Thr Asn Tyr Asp His Gly Glu Val Val Asp 150 155 160 165 gag gac acc gtc cga ttc falls ttc tet gag ect gca ect ggt ttt gct 643 Glu Asp Thr Val Arg Phe His Phe Ser Glu Pro Wing Pro Gly Phe Wing 170 175 180 cag gcc acc age tcc tcc aac gct gcc ctt tat gcc gat tcc acc ttg 691 Gln Wing Thr Being Ser Phe Asn Wing Gly Leu Tyr Wing Asp Being Thr Leu 185 190 195 25 gag ttc gcc aat gag gat ttc gcg cca ggc aac gcc caac aac gtc ate 739 Glu Phe Wing Asn Glu Asp Phe Wing Pro Gly Asn Wing Gln Asn Val He 200 205 210 ggc tc ggt ect ttc gtg ate acc gat gaa acccta ggc acc aac etc 787 Gly Ser Gly Pro Phe Val He Thr Asp Glu Thr Leu Gly Thr Asn Leu 215 220 225 acc ttg act gcg cgt gag gat tac gat tgg gca cca cca tea cgc gaa 835 Thr Leu Thr Wing Arg Glu Asp Tyr Asp Trp Wing Pro Pro Ser Arg Glu 230 235 240 245 • 5 cat ca ggt cgc gcg aag ctt gac gcc gtc aat tat gtc etc gcg ggt 883 His Gln Gly Arg Ala Lys Leu Asp Ala Val Asn Tyr Val Leu Ala Gly 250 255 260 gaa gaa tcc gtc cgc ate gga gct ate gtt gct ggc ca ggt gat ate 931 Glu Glu Ser Val Arg He Gly Wing He Val Wing Gly Gln Gly Asp He 265 270 275 gcc cgc cag ate gaa gcg cca gtg gag gca falls ctg aag gat gca ggc 979 Wing Arg Gln He Glu Ala Pro Val Glu Ala His Leu Lys Asp Ala Gly 280 285 290 ate ccg ate ate tcc gca gcc acc aac ggt gtg aac aac age ttc aac 1027 He Pro He He Ser Ala Ala Thr Asn Gly Val Asn Asn Ser Phe Asn 295 300 305 JQ ttc cgc ttc aaa aac gag ctg etc tea gac ate cgt gtt cgc ca gct 1075 Phe Arg Phe Lys Asn Glu Leu Leu Ser Asp He Arg Val Arg Gln Ala 310 315 320 325 • ctg ate cae gcg ate gac cgc gaa aag ate atg cgt gtg ctg ttt agt 1123 Leu He His Wing He Asp Arg Glu Lys He Met Arg Val Leu Phe Ser 330 335 340 gat tcc tat ccg ctg gca act tet gtg ctt gcg caa aat gca ctg ggc 1171 Asp Ser Tyr Pro Leu Wing Thr Ser Val Leu Wing Gln Asn Wing Leu Gly 345 350 355 tac aaa gaa ca gta gat gcc tat gtc tac gac cta gac aaa gca here 1219 Tyr Lys Glu Gln Val Asp Wing Tyr Val Tyr Asp Leu Asp Lys Wing Thr 360 365 370 JJ gct ctg ctt gac gaa gcc ggg tgg acc ctt gat age gac ggc atg cgt 1267 Wing Leu Leu Asp Glu Wing Gly Trp Thr Leu Asp Being Asp Gly Met Arg 375 380 385 cgc aag gac ggt gaa ctt cta gag etc acc ttc aac gaac gcc etc cca 1315 Arg Lys Asp Gly Glu Leu Leu Glu Leu Thr Phe Asn Glu Wing Leu Pro 390 395 400 405 cag ect cgt tea cgc gaa gtt gtc acc atg gtc caa gaa cag etc ggt 1363 Gln Pro Arg Ser Arg Glu Val Val Thr Met Val Gln Glu Gln Leu Gly 410 415 420 gat ctg ggc ate aag gtc aac etc aac cca ggt gac ca gca gcc cag 1411 Asp Leu Gly He Lys Val Asn Leu Asn Pro Gly Asp Gln Ala Wing Gln 425 430 435 2Q gac gct gac tcc aag gat aac aag aga cag gtt cgc falls acc atg 1459 Asp Wing Asp Ser Lys Asp Leu Asn Lys He Gln Val Arg His Thr Met 440 445 450 gtg ggt cgc gca gac tat gac gtg ctg aaa tcc cag ctg tac tcc acc 1507 Val Gly Arg Wing Asp Tyr Asp Val Leu Lys Ser Gln Leu Tyr Ser Thr 455 460 465 aac cgc aac gag ctg ttg aac atg acc gtg gaa ggg gag acc gcc gat 1555 Asn Arg Asn G Lu Leu Leu Asn Met Thr Val Glu Gly Glu Thr Wing Asp 470 475 480 485 att ggc gat ect cat ttg gag gaa etc etc atg gct att gca tcc age 1603 He Gly Asp Pro His Leu Glu Glu Leu Leu Met Wing He Wing Being 490 495 500 25 cca cgc gaa gag gac cgt gca gca gca tet gcc gca gca cag gat tac 1651 g ^ ü? m ^ Pro Arg Glu Glu Asp Arg Wing Wing Wing Wing Wing Wing Gln Asp Tyr 505 510 515 ate acc gag cag gca tat gtt ctt cca ctg ttt gaa gag cca gtt gtc 1699 He Thr Glu Gln Ala Tyr Val Leu Pro Leu Phe Glu Glu Pro Val Val 520 525 530 tac ggc gtg cag ect tac gtg aag ggc ttt age ccc gaa gtg ate ggc 1747 Tyr Gly Val Gln Pro Tyr Val Lys Gly Phe Ser Pro Glu Val He Gly 535 540 545 cgc ccc age ttc tat gag acc tac att gac cat tcc age gac cat tcc 1795 • Arg Pro Ser Phe Tyr Glu Thr Tyr He Asp His Ser Ser Asp His Ser 550 555 560 565 agt gag gag gac taaatgacta cctcgcagat tet 1830 Ser Glu Glu Asp < 210 > 20 < 211 > 569 < 212 > PRT < 213 > Corynebacterium glutamicum 10 < 400 > 20 Val Phe Lys Lys His Arg His Gly Leu Gly Ser Pro Glu Thr Lys Pro 1 5 10 15 Arg Ser He Thr Arg Arg Phe Phe Thr Wing Wing Wing Thr Leu Wing • 20 25 30 Gly Leu Wing Val Leu Ser Gly Cys Thr Wing Gln Pro Ser Gln Wing Glu 35 40 45 Asp Asn Thr Leu Thr Tyr Leu Glu Pro Gln Phe Phe Arg Thr Leu Tyr 50 55 60 Pro Pro Be Wing Gly Phe Tyr Pro Asn Gly Ser Val Val Asn Asn He 65 70 75 80 Wing Asp Arg Leu Leu Tyr Gln Asp Pro Glu Thr Leu Glu Leu Lys Pro 15 85 90 95 Trp He Wing Thr Glu Leu Pro Glu Val Asn Glu Asp Wing Thr Glu Phe 100 105 110 Thr Phe Asn He Arg Thr Asp Val Thr Tyr Ser Asp Gly Thr Pro Leu 115 120 125 Thr Wing Glu Asn Val Val Lys Asn Phe Asp Leu Tyr Gly Leu Gly Asp 130 135 140 Gln Asp Arg Arg Leu Thr He Ser Glu Gln He Thr Asn Tyr Asp His 145 150 155 160 Gly Glu Val Val Asp Glu Asp Thr Val Arg Phe His Phe Ser Glu Pro 165 170 175 Wing Pro Gly Phe Wing Gln Wing Thr Ser Ser Phe Asn Wing Gly Leu Tyr 20 180 185 190 Wing Asp Ser Thr Leu Glu Phe Wing Asn Glu Asp Phe Wing Pro Gly Asn 1 95 200 205 Wing Gln Asn Val He Gly Ser Gly Pro Phe Val He Thr Asp Glu Thr 210 215 220 Leu Gly Thr Asn Leu Thr Leu Thr Wing Arg Glu Asp Tyr Asp Trp Wing 225 230 235 240 Pro Pro Ser Arg Glu His Gln Gly Arg Ala Lys Leu Asp Ala Val Asn 245 250 255 Tyr Val Leu Wing Gly Glu Glu Ser Val Arg He Gly Wing He Val Wing 260 265 270 Gly Gln Gly Asp He Wing Arg Gln He Glu Wing Pro Val Glu Wing His 25 275 280 285 Leu Lys Asp Wing Gly He Pro Wing Ser Wing Wing Thr Asn Gly Val 290 295 300 Asn Asn Ser Phe Asn Phe Arg Phe Lys Asn Glu Leu Leu Ser Asp He 305 310 315 320 Arg Val Arg Gln Wing Leu He His Wing He Asp Arg Glu Lys He Met 325 330 335 Arg Val Leu Phe Ser Asp Ser Tyr Pro Leu Wing Thr Ser Val Leu Wing 340 345 350 • 5 Gln Asn Wing Leu Gly Tyr Lys Glu Gln Val Asp Wing Tyr Val Tyr Asp 355 360 365 Leu Asp Lys Ala Thr Ala Leu Leu Asp Glu Ala Gly Trp Thr Leu Asp 370 375 380 Be Asp Gly Met Arg Arg Lys Asp Gly Glu Leu Leu Glu Leu Thr Phe 385 390 395 400 Asn Glu Ala Leu Pro Gln Pro Arg Ser Arg Glu Val Val Thr Met Val 405 410 415 Gln Glu Gln Leu Gly Asp Leu Gly He Lys Val Asn Leu Asn Pro Gly 420 425 430 Asp Gln Wing Wing Gln Asp Wing Asp Ser Lys Asp Leu Asn Lys He Gln 435 440 445 O Val Arg His Thr Met Val Gly Arg Wing Asp Tyr Asp Val Leu Lys Ser 450 455 460 Gln Leu Tyr Ser Thr Asn Arg Asn Glu Leu Asn Met Thr Val Glu 465 470 475 480 • Gly Glu Thr Wing Asp He Gly Asp Pro His Leu Glu Glu Leu Leu Met 485 490 495 Wing He Wing Being Pro Arg Glu Glu Asp Arg Wing Wing Wing Wing 500 505 510 Wing Wing Gln Asp Tyr He Thr Glu Gln Wing Tyr Val Leu Pro Leu Phe 515 520 525 Glu Glu Pro Val Val Tyr Gly Val Gln Pro Tyr Val Lys Gly Phe Ser 530 535 540 j5 Pro Glu Val He Gly Arg Pro Ser Phe Tyr Glu Thr Tyr He Asp His 545 550 555 560 Ser Ser Asp His Ser Ser Glu Glu Asp 565 < 210 > 21 < 211 > 858 < 212 > DNA < 213 > Corynebacterium glutamicum • < 220 > < 221 > CDS 20 < 222 > (101) .. (835) < 223 > RXN00784 < 400 > 21 gtcacatcag ttatcgcgcg gaatagttag cgggcgcatg tggttgggat atatgaataa 60 atctattcca actacgcgta aaacgaggac gtttaaagct atg tet att gaa ttc 115 Met Ser He Glu Phe 1 5 tcc gca cca gca aaa atg aaa ate gaa gtg tgg age gac ate atg tgc 163 Be Ala Pro Ala Lys Met Lys He Glu Val Trp Ser Asp He Met Cys 10 15 20 ccc ttc tgc tac ate ggc aaa aag cgc etc gac gac gcc cta agt acc 211 25 Pro Phe Cys Tyr He Gly Lys Lys Arg Leu Asp Asp Ala Leu Ser Thr .. ^ a ^ f ^ a ^ ^ Mato, 25 30 35 ttt gac cag gcc gga cgc ate gaa gtg gaa tac aag age ttc gaa etc 259 Phe Asp Gln Wing Gly Arg He Glu Val Glu Tyr Lys Ser Phe Glu Leu 40 45 50 atg cca ggc cta gaa acc fall cca ctg cgt tcc gac gtt gaa tac etc 307 Met Pro Gly Leu Glu Thr His Pro Leu Arg Ser Asp Val Glu Tyr Leu 55 60 65 gcc gac gcc aag ggc atg age etc gag cag gcc cgc caa atg aac ggc 355 Wing Asp Wing Lys Gly Met Being Leu Glu Gln Wing Arg Gln Met Asn Gly • 70 75 80 85 ca gtc ca gca atg gca ca gcc acc gga ctt gaa atg aat ect gac 403 Gln Val Gln Wing Met Wing Gln Wing Thr Gly Leu Glu Met Asn Pro Asp 90 95 100 gaa acc ate gcg gcc aac acc ate aac gcg cae cgc ctt acc cae ttc 451 Glu Thr He Ala Wing Asn Thr He Asn Wing His Arg Leu Thr His Phe 105 110 115 gcg aaa gcc falls ggc aag caá caa gaa gtg gcg cag gaa etc ttc aag 499 Wing Lys Wing His Gly Lys Gln Gln Glu Val Wing Gln Glu Leu Phe Lys 120 125 130 gct falls ttc gta gac ggc aag aac gtt gat gac etc gat gtg ctg gtc 547 10 Wing His Phe Val Asp Gly Lys Asn Val Asp Asp Leu Asp Val Leu Val 135 140 145 tcc att gct gca gag gtt ggt etc gat gcc agt gca gcc cgc gaa gct 595 Be Wing Wing Wing Glu Val Gly Leu Asp Wing Wing Wing Wing Arg Glu Wing • 150 155 160 165 etc gaa tcc gac gtg tac acc aac gaa gtc caa caa gac gtc cae gaa 643 Leu Glu As Asp Val Tyr Thr Asn Glu Val Gln Gln Asp Val His Glu 170 175 180 gcc cgc ca gcc gtc ca ggt gtc gtc ccc ttc ttt gta tcc gac cgc cgc 691 Wing Arg Gln Leu Gly Val Gln Gly Val Pro Phe Phe Val Phe Asp Arg 185 190 195 aaa tac gcc ate aac ggc gcc caa caa gaa gaa gta ttc acc ggc acc 739 15 Lys Tyr Wing He Asn Gly Wing Gln Gln Glu Glu Val Phe Thr Gly Thr 200 205 210 gta gaa aaa gcc ttc gaa gag tgg gca gcc gaa aac cca gtc age cca 787 Val Glu Lys Wing Phe Glu Glu Trp Wing Wing Glu Asn Pro Val Ser Pro 215 220 225 ttt gag gtc att gac ggc caa age tgc tcc gtc gac ggc acc tgc aac 835 Phe Glu Val He Asp Gly Gln Ser Cys Ser Val Asp Gly Thr Cys Asn 230 235 240 245 taacttttgg gacct: atgtg cgt 858 < 210 > 22 < 211 > 245 20 < 212 > PRT < 213 > Ccirynebact: erium gl .utamicum < 400 > 22 Met Ser He Glu Phe Be Wing Pro Wing Lys Met Lys He Glu Val Trp 1 5 10 15 Be Asp He Met Cys Pro Phe Cys Tyr He Gly Lys Lys Arg Leu Asp 20 25 30 Asp Ala Leu Ser Thr Phe Asp Gln Ala Gly Arg He Glu Val Glu Tyr 35 40 45 Lys Ser Phe Glu Leu Met Pro Gly Leu Glu Thr His Pro Leu Arg Ser 50 55 60 25 Asp Val Glu Tyr Leu Wing Asp Wing Lys Gly Met Ser Leu Glu Gln Wing 65 70 75 80 Arg Gln Met Asn Gly Gln Val Gln Wing Met Wing Gln Wing Thr Gly Leu 85 90 95 Glu Met Asn Pro Asp Glu Thr He Wing Wing Asn Thr He Asn Wing His 100 105 110 Arg Leu Thr His Phe Wing Lys Wing His Gly Lys Gln Gln Glu Val Ala 115 120 125 Gln Glu Leu Phe Lys Ala His Phe Val Asp Gly Lys Asn Val Asp Asp 130 135 140 Leu Asp Val Leu Val Ser He Ala Ala Glu Val Gly Leu Asp Ala Ser 145 150 155 160 Ala Ala Arg Glu Ala Leu Glu Be Asp Val Tyr Thr Asn Glu Val Gln 165 170 175 Gln Asp Val His Glu Wing Arg Gln Leu Gly Val Gln Gly Val Pro Phe 180 185 190 Phe Val Phe Asp Arg Lys Tyr Wing He Asn Gly Wing Gln Gln Glu Glu 195 200 205 Val Phe Thr Gly Thr Val Glu Lys Ala Phe Glu Glu Trp Ala Ala Glu 210 215 220 Asn Pro Val Ser Pro Phe Glu Val He Asp Gly Gln Ser Cys Ser Val 10 225 230 235 240 Asp Gly Thr Cys Asn 245 • < 210 > 23 < 211 > 1896 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1873) 15 < 223 > RXA02335 < 400 > 23 tggttgagtt cttcggggtt gagtgtgeaa gaatattcac tattggtcag gcaactatgt 60 gtctacccac tgagtcatca atttaaatca ggagttatta gtg tea gtc gag act 115 Val Ser Val Glu Thr 1 5 agg aag ate acc aag gtt ctt gtc gct aac cgt ggt gag att gca ate 163 Arg Lys He Thr Lys Val Leu Val Wing Asn Arg Gly Glu He Wing He • 10 15 20 cgc gtg ttc cgt gca gct cga gat gaa ggc atg gga tet gtc gcc gtc 211 Arg Val Phe Arg Ala Wing Arg Asp Glu Gly Met Gly Ser Val Wing Val 20 25 30 35 tac gca gag cca gat gca gat gca cca ttc gtg tea tat gca gac gag 259 Tyr Wing Glu Pro Asp Wing Asp Wing Pro Phe Val Ser Tyr Wing Asp Glu 40 45 50 gct ttt gcc ggt ggc gc gc gcc cac here gcc gacc tcc tac ctt gtc att 307 Wing Phe Wing Leu Gly Gly Gln Thr Ser Wing Glu Ser Tyr Leu Val He 55 60 65 gac aag ate ate gcg gcc cgc aag tcc ggc gcc gacc gcc ate cae 355 Asp Lys He He Asp Ala Ala Arg Lys Ser Gly Ala Asp Ala He His 70 75 80 85 ccc ggc tac ggc ttc etc gca gaa aac gct gac ttc gca gaa gca gtc 403 Pro Gly Tyr Gly Phe Leu Wing Glu Asn Wing Asp Phe Wing Glu Wing Val 25 90 95 100 ate aac gaa ggc ctg ate tgg att gga ect tea ect gag tcc ate cgc 451 He Asn Glu Gly Leu He Trp He Gly Pro Ser Glu Be He Arg 105 110 115 tcc etc ggc gac aag gtc acc gct cgc cae ate gca gat acc gcc aag 499 Ser Leu Gly Asp Lys Val Thr Wing Arg His He Wing Asp Thr Wing Lys 120 125 130 gct cca atg gct ect ggc acc aag gaa cca gta aaa gac gca gca gaa 547 Wing Pro Met Wing Pro Gly Thr Lys Glu Pro Val Lys Asp Wing Wing Glu 135 140 145 gtt gtg gct tct gct gaa gaa ttc ggt etc cca ate gcc ate aag gca 595 Val Val Ala Phe Ala Glu Glu Phe Gly Leu Pro He Ala He Lys Ala 150 155 160 165 gct ttc ggt ggc ggc gga cgt ggc atg aag gtt gcc tac aag atg gaa 643 Wing Phe Gly Gly Gly Gly Arg Gly Met Lys Val Wing Tyr Lys Met Glu 170 175 180 gaa gtc gct gac etc ttc gag tcc gca acc cgt gaa gca acc gca gcg 691 Glu Val Wing Asp Leu Phe Glu Ser Wing Thr Arg Glu Wing Thr Wing Wing 185 190 195 ttc ggc cgc ggc gag tgc ttc gtg gag cgc tac ctg gac aag gca cgc 739 Phe Gly Arg Gly Glu Cys Phe Val Glu Arg Tyr Leu Asp Lys Ala Arg 10 200 205 210 fall gtt gag gct cag gtc ate gcc gat aag fall ggc aac gtt gtt gtc 787 His Val Glu Ala Gln Val He Wing Asp Lys His Gly Asn Val Val Val 215 220 225 • gcc gga acc cgt gac tgc tcc ctg cag cgc cgt ttc cag aag etc gtc 835 Wing Gly Thr Arg Asp Cys Ser Leu Gln Arg Arg Phe Gln Lys Leu Val 230 235 240 245 gaa gaca gca cca gca cca ttc etc acc gat gac cag cgc gag cgt etc 883 Glu Glu Wing Pro Wing Pro Phe Leu Thr Asp Asp Gln Arg Glu Arg Leu 250 255 260 drops tcc tcc gcg aag gct ate tgt aag gaa gct ggc tac tac ggt gca 931 His Ser Being Ala Lys Ala He Cys Lys Glu Ala Gly Tyr Tyr Gly Ala 15 265 270 275 ggc acc gtt gag tac etc gtt ggc tcc gac ggc ctg ate tcc ttc etc 979 Gly Thr Val Glu Tyr Leu Val Gly Ser Asp Gly Leu He Ser Phe Leu 280 285 290 gag gtc aac acc cgc etc cag gtg gaa falls cca gtc acc gaa gag acc 1027 Glu Val Asn Thr Arg Leu Gln Val Glu His Pro Val Thr Glu Glu Thr 295 300 305 acc ggc ate gac ctg gtc cgc gaa atg ttc cgc ate gca gaa ggc cae 1075 Thr Gly He Asp Leu Val Arg Glu Met Phe Arg He Wing Glu Gly His • 310 315 320 325 gag etc tcc ate aag gaa gat cca gct cca cgc ggc cae gca ttc gag 1123 Glu Leu Ser He Lys Glu Asp Pro Wing Pro Arg Gly His Wing Phe Glu 20 330 335 340 ttc cgc ate aac ggc gaa gac gct ggc tcc aac ttc atg ect gca cca 1171 Phe Arg He Asn Gly Glu Asp Wing Gly Ser Asn Phe Met Pro Wing Pro 345 350 355 ggc aag ate age acc tac cgc gag cca cag ggc cca ggc gtc cgc atg 1219 Gly Lys He Thr Ser Tyr Arg Glu Pro Gln Gly Pro Gly Val Arg Met 360 365 370 gac tcc ggt gtc gtt gaa ggt tcc gaa ate tcc gga cag ttc gac tcc 1267 Asp Ser Gly Val Val Glu Gly Ser Glu He Ser Gly Gln Phe Asp Ser 375 380 385 atg ctg gca aag ctg ate gtt tgg ggc gac acc cgc gag cag gct etc 1315 Met Leu Ala Lys Leu He Val Trp Gly Asp Thr Arg Glu Gln Ala Leu 25 390 395 400 405 ^ w ^ ^^^ j * cag cgc tcc cgc cgt gca ctt gca gag tac gtt gtc gag ggc atg cca 1363 Gln Arg Ser Arg Arg Wing Leu Wing Glu Tyr Val Val Glu Gly Met Pro 410 415 420 Acc gtt ate cca ttc falls cag cae ate gtg gaa aac cca gca ttc gtg 1411 Thr Val He Pro Phe His Gln His He Val Val Glu Asn Pro Ala Phe Val 425 430 435 ggc aac gac gaa ggc ttc gag ate tac acc aag tgg ate gaa gag gtt 1459 Gly Asn Asp Glu Gly Phe Glu He Tyr Thr Lys Trp He Glu Glu Val 440 445 450 tgg gat aac cca ate gca ect tac gtt gac gct tcc gag etc gac gaa 1507 Trp Asp Asn Pro He Wing Pro Tyr Val Asp Wing Ser Glu Leu Asp Glu 455 460 465 gat gag gac aag ac cca gca cag aag gtt gtt gtg gag ate aac ggc 1555 Asp Glu Asp Lys Thr Pro Wing Gln Lys Val Val Val Glu He Asn Gly 470 475 480 485 cgc cgc gtt gag gtt gca etc cca ggc gat ctg gca etc ggt ggc acc 1603 Arg Arg Val Glu Val Ala Leu Pro Gly Asp Leu Ala Leu Gly Gly Thr 490 495 500 gct ggt ect aag aag aag gcc aag aag cgt cgc gca ggt ggt gca aag 1651 Wing Gly Pro Lys Lys Lys Wing Lys Lys Arg Arg Wing Gly Gly Wing Lys 10 505 510 515 gct ggc gta tcc ggc g g g gg gca gca gca cca atg cag ggc gtc act 1699 Wing Gly Val Ser Gly Asp Wing Val Wing Wing Pro Met Gln Gly Thr Val 520 525 530 • ate aag gtc aac gtc gaa gaa ggc gct gaa gtc aac gaa ggc gac acc 1747 He Lys Val Asn Val Glu Glu Gly Wing Glu Val Asn Glu Gly Asp Thr 535 540 545 gtt gtt gtc etc gag gct atg aag atg gaa aac ect gtg aag gct cat 1795 Val Val Val Leu Glu Ala Met Lys Met Glu Asn Pro Val Lys Ala His 550 555 560 565 aag tcc gga acc gtact ggc ctt act gtc gct gca ggc gag ggt gtc 1843 Lys Ser Gly Thr Val Thr Gly Leu Thr Val Wing Wing Gly Glu Gly Val 15 570 575 580 aac aag ggc gtt gtt etc etc gag ate aag taagttcttg gattcctgtt 1893 Asn Lys Gly Val Val Leu Leu Glu He Lys 585 590 Agt 1896 < 210 > 24 < 211 > 591 < 212 > PRT • < 213 > Corynebacterium glutamicum < 400 > 24 20 Val Ser Val Glu Thr Arg Lys He Thr Lys Val Leu Val Wing Asn Arg 1 5 10 15 Gly Glu He Wing He Arg Val Phe Arg Wing Wing Arg Asp Glu Gly Met 20 25 30 Gly Ser Val Wing Val Tyr Wing Glu Pro Asp Ala Asp Ala Pro Phe VaJ 35 40 45 Ser Tyr Ala Asp Glu Ala Phe Ala Leu Gly Gly Gln Thr Ser Ala Glu 50 55 60 Ser Tyr Leu Val He Asp Lys He He Asp Ala Ala Arg Lys Ser Gly 65 70 75 80 Ala Asp Wing He His Pro Gly Tyr Gly Phe Leu Wing Glu Asn Wing Asp 85 90 95 25 Phe Ala Glu Ala Val He Asn Glu Gly Leu He Trp He Gly Pro Ser 100 105 110 Pro Glu Ser He Arg Ser Leu Gly Asp Lys Val Thr Ala Arg His He 115 120 125 Wing Asp Thr Ala Lys Wing Pro Met Wing Pro Gly Thr Lys Glu Pro Val 130 135 140 Lys Asp Wing Wing Glu Val Val Wing Phe Wing Glu Glu Phe Gly Leu Pro 145 150 155 160 He Wing He Lys Wing Wing Phe Gly Gly Gly Gly Arg Gly Met Lys Val 165 170 175 • Wing Tyr Lys Met Glu Glu Val Wing Asp Leu Phe Glu Ser Wing Thr Arg 180 185 190 Glu Wing Thr Wing Wing Phe Gly Arg Gly Glu Cys Phe Val Glu Arg Tyr 195 200 205 Leu Asp Lys Ala Arg His Val Glu Ala Gln Val He Wings Asp Lys His 210 215 220 Gly Asn Val Val Val Wing Gly Thr Arg Asp Cys Ser Leu Gln Arg Arg 225 230 235 240 Phe Gln Lys Leu Val Glu Glu Ala Pro Wing Pro Phe Leu Thr Asp Asp 245 250 255 Gln Arg Glu Arg Leu His Ser Be Ala Lys Ala He Cys Lys Glu Ala 10 260 265 270 Gly Tyr Tyr Gly Ala Gly Thr Val Glu Tyr Leu Val Gly Ser Asp Gly 275 280 285 Leu He Ser Phe Leu Glu Val Asn Thr Arg Leu Gln Val Glu His Pro • 290 295 300 Val Thr Glu Glu Thr Thr Gly He Asp Leu Val Arg Glu Met Phe Arg 305 310 315 320 He Wings Glu Gly His Glu Leu Ser He Lys Glu Asp Pro Wing Pro Arg 325 330 335 Gly His Wing Phe Glu Phe Arg He Asn Gly Glu Asp Wing Gly Ser Asn 340 345 350 Phe Met Pro Wing Pro Gly Lys He Thr Ser Tyr Arg Glu Pro Gln Gly 15 355 360 365 Pro Gly Val Arg Met Asp Ser Gly Val Val Glu Gly Ser Glu Ser 370 375 380 Gly Gln Phe Asp Ser Met Leu Ala Lys Leu He Val Trp Gly Asp Thr 385 390 395 400 Arg Glu Gln Ala Leu Gln Arg Ser Arg Arg Ala Leu Ala Glu Tyr Val 405 410 415 Val Glu Gly Met Pro Thr Val He Pro Phe His Gln His He Val Glu 420 425 430 • Asn Pro Ala Phe Val Gly Asn Asp Glu Gly Phe Glu He Tyr Thr Lys 435 440 445 Trp lie Glu Glu Val Trp Asp Asn Pro He Wing Pro Tyr Val Asp Ala 20 450 455 460 Ser Glu Leu Asp Glu Asp Glu Asp Lys Thr Pro Wing Gln Lys Val Val 465 470 475 480 Val Glu He Asn Gly Arg Arg Val Glu Val Ala Leu Pro Gly Asp Leu 485 490 495 Wing Leu Gly Gly Thr Wing Gly Pro Lys Lys Lys Wing Lys Lys Arg Arg 500 505 510 Wing Gly Wing Wing Lys Wing Wing Gly Val Ser Gly Wing Asp Val Ala Ala Pro 515 520 525 Met Gln Gly Thr Val He Lys Val Asn Val Glu Glu Gly Ala Glu Val 530 535 540 Asn Glu Gly Asp Thr Val Val Val Leu Glu Ala Met Lys Met Glu Asn 25 545 550 555 560 Pro Val Lys Ala His Lys Ser Gly Thr Val Thr Gly Leu Thr Val Wing 565 570 575 Wing Gly Glu Gly Val Asn Lys Gly Val Val Leu Leu Glu He Lys 580 585 590 < 210 > 25 < 211 > 1575 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1552) < 223 > RXA02173 < 400 > 25 ctaaattggg <; tta < gatett ccgcctctaa at; aggt; atgc agagacatte < gaattaatta 60 acaaagccat 1tttt < cggccg t < ggagaaget j ttttccgact atg gtg tgg ggc atg 115 Met Val Trp Gly Met 1 5 gaa falls act tea gca ttg acg etc ata gac tcg gtt ttg gac ect gac 163 Glu His Thr Ser Ala Leu Thr Leu He Asp Ser Val Leu Asp Pro Asp 10 15 20 age ttc att tet tgg aat gaa act ccc cata tat gac aac etc aat caa 211 Be Phe He Ser Trp Asn Glu Thr Pro Gln Tyr Asp Asn Leu Asn Gln 25 30 35 ggc tat gca gag acc ttg gag cgg gct cga age aag gcc aaa tgc gat 259 Gly Tyr Ala Glu Thr Leu Glu Arg Ala Arg Ser Lys Ala Lys Cys Asp 40 45 50 gaa tcg gta att act gga gaa ggc acc gtg gag ggc att ccg gta gcc 307 Glu Ser Val He Thr Gly Glu Gly Thr Val Glu Gly He Pro Val Wing 55 60 65 gtt att ttg tcc gat ttt tcc ttc etc ggc ggt tet ttg ggc acg gtc 355 Val He Leu Ser Asp Phe Ser Phe Leu Gly Gly Ser Leu Gly Thr Val 70 75 80 85 gcg tcg gtg cgc ate atg aag gcg att cae cgc gcc here gag ctg aaa 403 Ala Ser Val Arg He Met Lys Wing He His Arg Wing Thr Glu Leu Lys 90 95 100 etc cca ctg ctg gtc tcc ect gct tcc ggt ggt gcg cgc atg cag gaa 451 Leu Pro Leu Leu Val Ser Pro Wing Ser Gly Gly Wing Arg Met Gln Glu 105 110 115 gac aat cga gct ttt gtc atg gtg gtg tcc ata gcg acc gcg cag 499 Asp Asn Arg Wing Phe Val Met Met Val Ser He Thr Wing Wing Val Gln 120 125 130 cgt falls cgc gag gcg cat ttg ccg ttc ctg gtg tat ttg cgc aat ccc 547 Arg His Arg Glu Wing His Leu Pro Phe Leu Val Tyr Leu Arg Asn Pro 135 140 145 acg atg ggt ggc gcc atg gcc tcg tgg ggt tea tet ggg cat etc act 595 Thr Met Gly Gly Wing Met Wing Ser Trp Gly Ser Ser Gly His Leu Thr 150 155 160 165 ttt gcg gaa ccc ggc gcg cag ata ggt ttc ctg ggt ect cgc gtg gtg 643 Phe Ala Glu Pro Gly Ala Gln He Gly Phe Leu Gly Pro Arg Val Val 170 175 180 gag tta acc act ggg cat gcg ctt cca gac ggt gtg cag cag gcg gag 691 Glu Leu Thr Thr Gly His Wing Leu Pro Asp Gly Val Gln Gln Wing Glu 185 190 195 aat ttg gtg aaa act ggt gtg att gat gga att gtg tcg cca etc ca 739 Asn Leu Val Lys Thr Gly Val He Asp Gly He Val Ser Pro Leu Gln 200 205 210 ttg cgt gca gcg gtg gca aaa acc etc aag gtt att cag ccg gta gag 787 Leu Arg Ala Ala Val Ala Lys Thr Leu Lys Val He Gln Pro Val Glu 215 220 225 gca acg gat cgt ttt tet cca here act ect ggc gtc gc gc ctt gtg 835 Wing Thr Asp Arg Phe Ser Pro Thr Thr Pro Gly Val Wing Leu Pro Val 235 240 245 atg gag gcg att gcg cgt tet cgt gac ccg cag agg ect gga ate ggg 883 • Met Glu Ala He Wing Arg Ser Arg Asp Pro Gln Arg Pro Gly He Gly 250 255 260 gag att atg gaa acg ttg ggg gca gac gtc gtc aag ctt tet ggt gcg 931 Glu He Met Glu Thr Leu Gly Wing Asp Val Val Lys Leu Ser Gly Wing 265 270 275 cgt gct ggc gca ttg age ccg gct gtg cgc gtt gcc ctg gcg cgc ate 979 Arg Ala Gly Ala Leu Ser Pro Ala Val Arg Val Ala Leu Ala Arg He 280 285 290 ggg ggc cgg ccc gtg gtg ctg att ggg ca g gat cgc cgc ttc acg ctt 1027 Gly Gly Arg Pro Val Val Leu He Gly Gln Asp Arg Arg Phe Thr Leu 295 300 305 ccg cag gag ctg cgt ttt gcg cgt cgt ggc att tcg ctg gcg cgc 10 ggg 1075 Gly Pro Gln Glu Leu Arg Phe Wing Arg Arg Gly He Ser Leu Wing Arg 310 315 320 325 gag cta aac ctg ccg ate gtg tcc ate ate gac acc tcc ggc gcc gaa 1123 • Glu Leu Asn Leu Pro He Val Ser He He Asp Thr Ser Gly Ala Glu 330 335 340 ttg tcg cag gcg gct gag gag etc ggc ate gca age tcg att gcg cgc 1171 Leu Ser Gln Wing Wing Glu Glu Leu Gly He Wing Being Ser Wing Wing Arg 345 350 355 acc ttg tcc aag ctt ate gac gct ccc etc ccc acc gtt tcg gtc att 1219 Thr Leu Ser Lys Leu He Asp Wing Pro Pro Leu Pro Thr Val Ser Val He 360 365 370 att ggt 15 ggt cag ggc gtt ggc ggc gcg ctg gcc atg ctg ccc gcc gat 1267 He Gly Gln Gly Val Gly Gly Gly Wing Leu Wing Met Leu Pro Wing Asp 375 380 385 ctg gtc tac gcg gcc gaa aac gcg tgg ctg tcc gca ttg cca cca gag 1315 Leu Val Tyr Ala Wing Glu Asn Wing Trp Leu Ser Wing Leu Pro Pro Glu 390 395 4 00 405 ggc gcc tcg gcc ate etc tcc ccc gac acc aac falls gcc gcg gaa ate 1363 Gly Wing Being Wing He Leu Phe Arg Asp Thr Asn His Wing Wing Glu He 410 415 420 • ata gag cga ca ggc gg gg cag gc gca gtt tta age cag ggg ctt 1411 He Glu Arg Gln Gly Val Gln Ala His Wing Leu Leu Ser Gln Gly Leu 425 430 435 20 ate gac ggg ate gtc gcc gaa acc gag falls ttt gtt gaa gaa att etc 1459 He Asp Gly He Val Ala Glu Thr Glu His Phe Val Glu Glu He Leu 440 445 450 ggc here ate age aac gcc etc tcc gaa ttg gat aac aat ccg gag agg 1507 Gly Thr He Ser Asn Ala Leu Ser Glu Leu Asp Asn Asn Pro Glu Arg 455 460 465 gcg gga cgc gac agt cgc ttc here cga ttt gag cgt tta gcg cag 1552 Wing Gly Arg Asp Ser Arg Phe Thr Arg Phe Glu Arg Leu Wing Gln 470 475 480 taaaigaae? at tatgc: gctga tea 1575 < 210 > 26 25 < 211 > 484 .. • - «Aaiiii fei i ^ ÉSÉÉtoltti'T < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 26 Met Val Trp Gly Met Glu His Thr Ser Ala Leu Thr Leu He Asp Ser 1 5 10 15 Val Leu Asp Pro Asp Ser Phe He Ser Trp Asn Glu Thr Pro Gln Tyr 20 25 30 Asp Asn Leu Asn Gln Gly Tyr Ala Glu Thr Leu Glu Arg Ala Arg Ser 35 40 45 Lys Wing Lys Cys Asp Glu Ser Val He Thr Gly Glu Gly Thr Val Glu 50 55 60 Gly He Pro Val Wing Val He Leu Ser Asp Phe Ser Phe Leu Gly Gly 65 70 75 80 Ser Leu Gly Thr Val Wing Ser Val Arg He Met Lys Wing He His Arg 85 90 95 Wing Thr Glu Leu Lys Leu Pro Leu Leu Val Ser Pro Wing Ser Gly Gly 100 105 110 Wing Arg Met Gln Glu Asp Asn Arg Wing Phe Val Met Met Val Ser He 115 120 125 Thr Wing Wing Val Gln Arg His Arg Glu Wing His Leu Pro Phe Leu Val 130 135 140 Tyr Leu Arg Asn Pro Thr Met Gly Gly Wing Met Wing Ser Trp Gly Ser 145 150 155 160 Ser Gly His Leu Thr Phe Wing Glu Pro Gly Wing Gln He Gly Phe Leu 165 170 175 Gly Pro Arg Val Val Glu Leu Thr Thr Gly His Wing Leu Pro Asp Gly 180 185 190 Val Gln Gln Wing Glu Asn Leu Val Lys Thr Gly Val He Asp Gly He 195 200 205 Val Ser Pro Leu Gln Leu Arg Wing Wing Val Wing Lys Thr Leu Lys Val 210 215 220 He Gln Pro Val Glu Wing Thr Asp Arg Phe Ser Pro Thr Thr Pro Gly 225 230 235 240 Val Wing Leu Pro Val Met Glu Wing He Wing Arg Ser Arg Asp Pro Gln 245 250 255 Arg Pro Gly He Gly Glu He Met Glu Thr Leu Gly Wing Asp Val Val 260 265 270 Lys Leu Ser Gly Ala Arg Ala Gly Ala Leu Ser Pro Ala Val Arg Val 275 280 285 Ala Leu Ala Arg He Gly Gly Arg Pro Val Val Leu He Gly Gln Asp 290 295 300 Arg Arg Phe Thr Leu Gly Pro Gln Glu Leu Arg Phe Wing Arg Arg Gly 305 310 315 320 Be Ser Leu Ala Arg Glu Leu Asn Leu Pro He Val Ser He He Asp 325 330 335 Thr Ser Gly Wing Glu Leu Ser Gln Wing Wing Glu Glu Leu Gly He Wing 340 345 350 Being Ser Wing Arg Thr Leu Ser Lys Leu He Asp Wing Pro Leu Pro 355 360 365 Thr Val Ser Val He He Gly Gln Gly Val Gly Gly Gly Ala Leu Wing 370 375 380 Met Leu Pro Wing Asp Leu Val Tyr Wing Wing Glu Asn Wing Trp Leu Ser 385 390 395 400 Wing Leu Pro Pro Glu Gly Wing Wing Wing Leu Phe Arg Asp Thr Asn 405 41 0 415 His Ala Ala Glu He He Glu Arg Gln Gly Val Gln Ala His Ala Leu - 1 ii ilW lllll 420 425 430 Leu Ser Gln Gly Leu He Asp Gly He Val Wing Glu Thr Glu His Phe 435 440 445 Val Glu Glu He Leu Gly Thr He Ser Asn Ala Leu Ser Glu Leu Asp 450 455 460 Asn Asn Pro Glu Arg Ala Gly Arg Asp Ser Arg Phe Thr Arg Phe Glu 465 470 475 480 Arg Leu Ala Gln • < 210 > 27 < 211 > 1056 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1033) < 223 > RXA01764 < 400 > 27 10 ttttcaaaat 'taat, agttga cattttcaac gt'tatg, agtt tteattggta -tcacgccccg 60 acg, aagtgtc' tggg, atcaca aaccttcaaa gg, agtttgaa atg tet etc aat gga 115 Met Ser Leu Asn Gly 1 5 • aaa gtc gcc ate gtt acc gga tet ggt gca gga ctt ggt cgt tcc ttc 163 Lys Val Wing Val Thr Gly Ser Gly Wing Gly Leu Gly Arg Ser Phe 10 15 20 gct cag gag ctt gcc cgt cag ggt gca tet gtc ate gtc aat gac gta 211 Wing Gln Glu Leu Wing Arg Gln Gly Wing Ser Val He Val Asn Asp Val 25 30 35 aac cag gca gcc gca gat gag act gtc gca gca ate acc gaa gcc ggc 259 Asn Gln Wing Wing Wing Asp Glu Thr Val Wing Wing He Thr Glu Wing Gly 15 40 45 50 ggc aaa gcc gcc gcc gtt ate gcc ccc gtt gga ccc tet gaa age gcc 307 Gly Lys Wing Wing Wing Val He Wing Pro Val Gly Pro Ser Glu Wing Wing 55 60 65 gca ttg ctg gtg cgg gag gcc gtc gac aag ttc ggt tet ttg gac att 355 Wing Leu Leu Val Arg Glu Wing Val Asp Lys Phe Gly Ser Leu Asp He 70 75 80 85 ctt gtc here aac gcg ggc ate ctt cgt gat agg tcc ctg ctg aag atg 403 Leu Val Thr Asn Wing Gly He Leu Arg Asp Arg Ser Leu Leu Lys Met 90 95 100 acg gac gat gat ttc gat gca gtc att aac gtg drops etc aag ggc act 451 Thr Asp Asp Asp Phe Asp Wing Val He Asn Val His Leu Lys Gly Thr 20 105 110 115 ttc acc tgt gtt cgc gag gca ttt gga tac ttc aag gag aat gga ate 499 Phe Thr Cys Val Arg Glu Wing Phe Gly Tyr Phe Lys Glu Asn Gly He 120 125 130 gcg ggg cgc ate gtc acg att ggt tet ccc acc ggg cag cgc ggc aac 547 Wing Gly Arg He Val Thr He Gly Ser Pro Thr Gly Gln Arg Gly Asn 135 140 145 ttc gga cag age aat tac gct gca gct aag gcg ggc att gtg ggt atg 595 Phe Gly Gln Ser Asn Tyr Ala Ala Ala Lys Ala Gly He Val Gly Met 150 155 160 165 gtt cgc acg tgg gcg ctg gag atg aag cgc gca ggt gtc acc att aac 643 Val Arg Thr Trp Wing Leu Glu Met Lys Arg Wing Gly Val Thr He Asn 25 170 175 180 gcg ate att ccg gaa gca gcc acc gat atg acc aag acg gtg cca tat 691 Wing He He Pro Glu Wing Wing Thr Asp Met Thr Lys Thr Val Pro Tyr 185 190 195 ttc cag aag gta gag gcc gat gag cgt ggc gag gcc atg cca gca 739 Phe Gln Lys Wing Val Glu Wing Asp Glu Arg Gly Glu Wing Met Pro Wing 200 205 210 ttc tcc cgc gag acccta ggt ttt gcc act ect cag gat gtt gcg gga 787 Phe Phe Arg Glu Thr Leu Gly Phe Gly Thr Pro Gln Asp Val Ala Gly 215 220 225 ctt gtg gcc ttc ctt tcc tet gat gag gca gcg aat att tet gga cag 835 Leu Val Ala Phe Leu Ser Ser Asp Glu Ala Ala Asn He Ser Gly Gln 230 235 240 245 gcc ate ggt gca ggc ggc gac cgc atg cag gtg tgg aag falls cca gag 883 Wing He Gly Wing Gly Gly Asp Arg Met Gln Val Trp Lys His Pro Glu 250 255 260 cca gca gtt act gaa ttt aac cca ggt ggc tgg acc tat gaa gca ctg 931 Pro Ala Val Thr Glu Phe Asn Pro Gly Gly Trp Thr Tyr Glu Ala Leu 265 270 275 cag gaa cgt ggc aag aac att att gag ggc aac ctg cag tcc gtc ggt 979 Gln Glu Arg Gly Lys Asn He He Glu Gly Asn Leu Gln Ser Val Gly 280 285 290 gtc gtt ttc ect gaa ctg ccg gca gag ctt cag cca caa ate cca gtc 1027 Val Val Phe Pro Glu Leu Pro Wing Glu Leu Gln Pro Gln He Pro Val 295 300 305 aag gca taacaccgca caccaagaat ttt 1056 Lys Ala 310 < 210 > 2Ei < 211 > 311 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 28 Met Ser Leu Asn Gly Lys Val Wing He Val Thr Gly Ser Gly Wing Gly 1 5 10 15 Leu Gly Arg Ser Phe Wing Gln Glu Leu Wing Arg Gln Gly Wing Ser Val 20 25 30 He Val Asn Asp Val Asn Gln Wing Wing Wing Asp Glu Thr Val Wing Wing 35 40 45 He Thr Glu Wing Gly Gly Lys Wing Ala Ala Val He Ala Pro Val Gly 50 55 60 Pro Ser Glu Be Ala Ala Leu Leu Val Arg Glu Ala Val Asp Lys Phe 65 70 75 80 Gly Ser Leu Asp He Leu Val Thr Asn Wing Gly He Leu Arg Asp Arg 85 90 95 Be Leu Leu Lys Met Thr Asp Asp Asp Phe Asp Wing Val He Asn Val 100 105 110 His Leu Lys Gly Thr Phe Thr Cys Val Arg Glu Wing Phe Gly Tyr Phe 115 120 125 Lys Glu Asn Gly He Wing Gly Arg He Val Thr He Gly Ser Pro Thr 130 135 140 Gly Gln Arg Gly Asn Phe Gly Gln Ser Asn Tyr Ala Ala Ala Lys Ala 145 150 155 160 Gly He Val Gly Met Val Arg Thr Trp Wing Leu Glu Met Lys Arg Wing 165 170 175 Gly Val Thr He Asn Wing He He Pro Glu Wing Wing Thr Asp Met Thr 180 185 190 Lys Thr Val Pro Tyr Phe Gln Lys Wing Val Glu Wing Asp Glu Arg Gly 195 200 205 Glu Ala Met Pro Wing Phe Phe Arg Glu Thr Leu Gly Phe Gly Thr Pro 210 215 220 Gln Asp Val Wing Gly Leu Val Wing Phe Leu Ser Ser Asp Glu Ala Wing 225 230 235 240 Asn He Ser Gly Gln Wing He Gly Wing Gly Gly Asp Arg Met Gln Val 245 250 255 • Trp Lys His Pro Glu Pro Wing Val Thr Glu Phe Asn Pro Gly Gly Trp 260 265 270 Thr Tyr Glu Wing Leu Gln Glu Arg Gly Lys Asn He He Glu Gly Asn 275 2 80 285 Leu Gln Ser Val Gly Val Val Phe Pro Glu Leu Pro Ala Glu Leu Gln 290 295 300 Pro Gln He Pro Val Lys Ala 305 310 < 210 > 29 < 211 > 1827 10 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1804) < 223 > RXN02487 < 400 > 29 teatagetac gcgcatgccc acattetaga tcgccgaaga aageageggg acgtctctat 60 atactaaagg gcactaaagc aacgcagttg aagggacacc atg tea gca tac gaa 115 Met Ser Ala Tyr Glu 15 1 5 acc aaa gaa tgg etc cag falls tac cca gag tgg acg cca falls tcg ctg 163 Thr Lys Glu Trp Leu Gln His Tyr Pro Glu Trp Thr Pro His Ser Leu 10 15 20 gaa tat ggc gac acc acc ctg ctg gac gtt tac gac aac aac ctg gcc 211 Glu Tyr Gly Asp Thr Thr Leu Leu Asp Val Tyr Asp Asn Asn Leu Wing 25 30 35 att aac gca gac aag cca gcc acc tac ttt ttc ggt cgt tea caac acc 259 He Asn Wing Asp Lys Pro Wing Thr Tyr Phe Phe Gly Arg Ser Gln Thr 40 45 50 tac ggt gaa ctg gac aaa gaa gtc cgc aaa act gcc gct ggc ctg cgc 307 Tyr Gly Glu Leu Asp Lys Glu Val Arg Lys Thr Wing Wing Gly Leu Arg 20 55 60 65 gca cta ggt gtc cgc ccc ggc gat cae gta gcg att ate etc ccc aac 355 Wing Leu Gly Val Arg Pro Gly Asp His Val Wing He He Leu Pro Asn 70 75 80 85 tgc cca cag falls gca gct tct gc gc tcg gtg aaa etc ggc gca gc 403 Cys Pro Gln His He Wing Wing Phe Tyr Wing Val Leu Lys Leu Gly Wing 90 95 100 gta gtc att gag falls aac ccg etc tac acc gcc falls gaa ctg etc gaa 451 Val Val He Glu His Asn Pro Leu Tyr Thr Ala His Glu Leu Leu Glu 105 110 115 ccc ttc aaa gac falls ggt gcc gcg cgc gtt gcc gtc tgg gac aaa gcc 499 Pro Phe Lys Asp His Gly Wing Arg Val Wing Val Trp Asp Lys Wing 25 120 125 130 tcc ccc acc gtc gaa cag cta cgt gga cag acc cag ttg gaa acc ate 547 Be Pro Thr Val Glu Gln Leu Arg Gly Gln Thr Gln Leu Glu Thr He 135 140 145 gtg tcg gtc aac atg a gcg atg cca cca cca etc cag cgc cta gca 595 Val Ser Val Asn Met He Asn Wing Met Pro Pro Leu Gln Arg Leu Ala 150 155 160 165 ctt cgg etc cca ate ect gca ctg cgc aag age cgc gaa tcc etc tcc 643 Leu Arg Leu Pro He Pro Wing Leu Arg Lys Ser Arg Glu Ser Leu Ser 170 175 180 ggc gca gcc ccc aac acc gtt ect ttt gaa acc ctg acc age gca gca 691 Gly Ala Wing Pro Asn Thr Val Pro Phe Glu Thr Leu Thr Ser Wing Wing 185 190 195 atg ggc ggc gac ggc gac gac gta gtt tea gaa ccc acc gtg acc aaa 739 Met Gly Gly Asp Gly Asp Asp Val Val Ser Glu Pro Thr Val Thr Lys 200 205 210 gaa tcc gtc gcg ctg ate etc tac acc tcc ggc ac acc gga cgc ccc 787 Glu Ser Val Ala Leu He Leu Tyr Thr Ser Gly Thr Thr Gly Arg Pro 215 220 225 aag ggt gcc cag etc acc fall gga aac ctg ttc ttc aat ctt ctt cca ca 835 Lys Gly Ala Gln Leu Thr His Gly Asn Leu Phe Phe Asn Leu Leu Gln 230 235 240 245 gga aag falls tgg gtt cca ggt etc gga gac aaa cca gaa cgc atg ctt 883 Gly Lys His Trp Val Pro Gly Leu Gly Asp Lys Pro Glu Arg Met Leu 250 255 260 gca gcc cta cca atg ttc falls gca tac ggt ctg acc atg gtc ggc here 931 Ala Ala Leu Pro Met Phe His Ala Tyr Gly Leu Thr Met Val Gly Thr 265 270 275 ctg tcc gtg ttc ate ggt ggc gaa atg gtg cta ctt ccc acc cca cgc 979 Leu Ser Val Phe He Gly Gly Glu Met Val Leu Leu Pro Thr Pro Arg 280 285 290 ate gac ctg ate atg aac gta atg aaa aag falls ac c ade acc attage 1027 He Asp Leu He Met Asn Val Met Lys Lys His Thr Pro Thr Trp Leu 295 300 305 cca ggc gtg ccc acc ctt tac gaa aaa ate gtc gac gcc tcc gaa aaa 1075 Pro Gly Val Pro Thr Leu Tyr Glu Lys He Val Asp Ala Ser Glu Lys 310 315 320 325 gaa gga ate ccc ate aag ggac cgc aac gcc ttc tcc ggt gca tcc 1123 Glu Gly He Pro He Lys Gly Val Arg Asn Wing Phe Ser Gly Wing Ser 330 335 340 here etc tcc cag cgc acc gtt gaa cgc tgg gaa aag falls acc ggc gga 1171 Thr Leu Ser Gln Arg Thr Val Glu Arg Trp Glu Lys His Thr Gly Gly 345 350 355 cgc etc gtc gaa ggc tac ggc etc acc gaa acc tcc ccc ate ate gtg 1219 Arg Leu Val Glu Gly Tyr Gly Leu Thr Glu Thr Ser Pro He He Val 360 365 370 ggt aac ccc atg age gat fall cga cgc ca ggc tac gta gga ate ccc 1267 Gly Asn Pro Met As Asp His Arg Arg Gln Gly Tyr Val Gly He Pro 375 380 385 ttc ccc gac acc ate gtg cgc ate gca aac cca gaa aac etc gac gaa 1315 Phe Pro Asp Thr He Val Arg He Wing Asn Pro Glu Asn Leu Asp Glu 390 395 400 405 acc atg ccc gac ggc age gaa ggc gaa gtc cta gtc aag ggc cca cag 1363 Thr Met Pro Asp Gly Ser Glu Gly Glu Val Leu Val Lys Gly Pro Gln 410 415 420 gtg ttc aag ggt tac etc aac cag gaa gaa gcc acc aag aac age ttc 1411 Val Phe Lys Gly Tyr Leu Asn Gln Glu Glu Wing Thr Lys Asn Ser Phe 425 430 435 falls ggc gag tgg tac cgc acc ggc gac gtc gga gtg atg gaa gaa gac 1459 His Gly Glu Trp Tyr Arg Thr Gly Asp Val Gly Val Met Glu Glu Asp 440 445 450 ggg ttc ate cgc cta gtt gct cgc ate aag gaa gtc ate ate act ggc 1507 Gly Phe He Arg Leu Val Wing Arg He Lys Glu Val He He Thr Gly 455 460 465 ggt ttc aac gtg tac cca gct gag gtt gaa gaa gtc etc gca gag drops 1555 Gly Phe Asn Val Tyr Pro Wing Glu Val Glu Glu Val Leu Wing Glu His 470 475 480 485 cca gac att gaa gat tcc gca gtc gtt ggt ate ccg cgt gaa gac ggc 1603 Pro Asp He Glu Asp Be Wing Val Val Gly He Pro Arg Glu Asp Gly 490 495 500 tcc gaa aac gtc gtt gct gcc ate act ttg gtg gaa ggt gca gcg ctg 1651 Ser Glu Asn Val Val Ala Ala He Thr Leu Val Glu Gly Ala Ala Leu 505 510 515 gat ccg gat ggc ctg aag gaa tcc gcc cgc aag aac etc acc ccc tac 1699 Asp Pro Asp Gly Leu Lys Glu Phe Wing Arg Lys Asn Leu Thr Arg Tyr 520 525 530 aag gtt ccg cgc act ttc tac falls ttt gag gag atg ccg cgg gat cag 1747 Lys Val Pro Arg Thr Phe Tyr His Phe Glu Glu Met Pro Arg Asp Gln 535 540 545 atg ggc aag att agg cgt cgt gaa gtg cag gcg gag ttg ttg aag aag 1795 Met Gly Lys He Arg Arg Arg Glu Val Gln Ala Glu Leu Leu Lys Lys 550 555 560 565 etc ggc aag tagaegeega tttaagaggt cga 1827 Leu Gly Lys < 210 > 30 <; 211 > 568 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 30 Met Ser Wing Tyr Glu Thr Lys Glu Trp Leu Gln His Tyr Pro Glu Trp 1 5 10 15 Thr Pro His Ser Leu Glu Tyr Gly Asp Thr Thu Leu Leu Asp Val Tyr 20 25 30 Asp Asn Asn Leu Wing He Asn Wing Asp Lys Pro Ala Thr Tyr Phe Phe 35 40 45 Gly Arg Ser Gln Thr Tyr Gly Glu Leu Asp Lys Glu Val Arg Lys Thr 50 55 60 Wing Wing Gly Leu Arg Wing Leu Gly Val Arg Pro Gly Asp His Val Wing 65 70 75 80 He He Leu Pro Asn Cys Pro Gln His He Ala Ala Phe Tyr Ala Val 85 90 95 Leu Lys Leu Gly Ala Val Val He Glu His Asn Pro Leu Tyr Thr Ala 100 105 110 His Glu Leu Leu Glu Pro Phe Lys Asp His Gly Ala Arg Val Wing He 115 120 125 Val Trp Asp Lys Wing Pro Pro Thr Val Glu Gln Leu Arg Gly Gln Thr 130 135 140 Gln Leu Glu Thr He Val Ser Val Asn Met He Asn Wing Met Pro Pro 145 150 155 160 Leu Gln Arg Leu Ala Leu Arg Leu Pro He Pro Wing Leu Arg Lys Ser 165 170 175 Arg Glu Ser Leu Ser Gly Wing Wing Pro Asn Thr Val Pro Phe Glu Thr 180 185 190 Leu Thr Ser Wing Wing Met Gly Gly Asp Gly Asp Asp Val Val Ser Glu 195 200 205 Pr or Thr Val Thr Lys Glu Ser Val Ala Leu He Leu Tyr Thr Ser Gly 210 215 220 Thr Thr Gly Arg Pro Lys Gly Wing Gln Leu Thr His Gly Asn Leu Phe 225 230 235 240 Phe Asn Leu Leu Gln Gly Lys His Trp Val Pro Gly Leu Gly Asp Lys 245 250 255 Pro Glu Arg Met Leu Ala Ala Leu Pro Met Phe His Wing Tyr Gly Leu 260 265 270 Thr Met Val Gly Thr Leu Ser Val Phe He Gly Gly Glu Met Val Leu 275 280 285 Leu Pro Thr Pro Arg He Asp Leu He Met Asn Val Met Lys Lys His 290 295 300 Thr Pro Thr Trp Leu Pro Gly Val Pro Thr Leu Tyr Glu Lys He Val 305 310 315 320 Asp Wing Ser Glu Lys Glu Gly He Pro He Lys Gly Val Arg Asn Wing 325 330 335 Phe Ser Gly Wing Ser Thr Leu Ser Gln Arg Thr Val Glu Arg Trp Glu 340 345 350 Lys His Thr Gly Gly Arg Leu Val Glu Gly Tyr Gly Leu Thr Glu Thr 355 360 365 Ser Pro He He Val Val Gly Asn Pro Met As Asp His Arg Arg Gln Gly 370 375 380 Tyr Val Gly He Pro Phe Pro Asp Thr He Val Arg He Wing Asn Pro 385 390 395 400 Glu Asn Leu Asp Glu Thr Met Pro Asp Gly Ser Glu Glu Val Leu 405 410 415 Val Lys Gly Pro Gln Val Phe Lys Gly Tyr Leu Asn Gln Glu Glu Wing 420 425 430 Thr Lys Asn Ser Phe His Gly Glu Trp Tyr Arg Thr Gly Asp Val Gly 435 440 445 Val Met Glu Glu Asp Gly Phe He Arg Leu Val Ala Arg He Lys Glu 450 455 460 Val He He Thr Gly Gly Phe Asn Val Tyr Pro Wing Glu Val Glu Glu 465 470 475 480 Val Leu Wing Glu His Pro Asp He Glu Asp Ser Wing Val Val Gly He 485 490 495 Pro Arg Glu Asp Gly Ser Glu Asn Val Val Ala Wing He Thr Leu Val 500 505 510 Glu Gly Wing Wing Leu Asp Pro Asp Gly Leu Lys Glu Phe Wing Arg Lys 515 520 525 Asn Leu Thr Arg Tyr Lys Val Pro Arg Thr Phe Tyr His Phe Glu Glu 530 535 540 Met Pro Arg Asp Gln Met Gly Lys He Arg Arg Arg Glu Val Gln Ala 545 550 555 560 Glu Leu Leu Lys Lys Leu Gly Lys 565 < 210 > 31 < 211 > 411 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS .. ^^ .. f.Asfc < 222 > (101) .. (388) < 223 > FRXA02487 < 400 > 31 ggcgagtggt accgcaccgc gacgtcggag tgatgaagaa gccgggttca tccgcctagt 60 tgctcgcatc aagaaagtca tcatcactgg cggtttcaac gtg tac cca gct gag 115 Val Tyr Pro Wing Glu 1 5 gtt gaa gaa gtc etc gca gag falls cca gac att gaa gat tcc gca gtc 163 Val Glu Glu Val Leu Wing Glu His Pro Asp He Glu Asp Ser Wing Val 10 15 20 gtt ggt ate ccg cgt gaa gac ggc tcc gaa aac gtc gtt gct gcc ate 211 Val Gly He Pro Arg Glu Asp Gly Ser Glu Asn Val Val Ala Ala He 25 30 35 act ttg gtg gaa ggt gca gcg ctg gat ccg gat ggc ctg aag gaa ttc 259 Thr Leu Val Glu Gly Ala Ala Leu Asp Pro Asp Gly Leu Lys Glu Phe 40 45 50 gcc cgc aag aac etc acc cgc tac aag gtt ccg cgc act ttc tac cae 307 Wing Arg Lys Asn Leu Thr Arg Tyr Lys Val Pro Arg Thr Phe Tyr His 55 60 65 10 ttt gag gag atg ccg cgg gat cag atg ggc aag att agg cgt cgt gaa 355 Phe Glu Glu Met Pro Arg Asp Gln Met Gly Lys He Arg Arg Arg Glu 70 75 80 85 gtg cag gcg gag ttg ttg aag aag etc ggc aag tagaegeega tttaagaggt 408 Val Gln Ala Glu Leu Leu Lys Lys Leu Gly Lys 90 95 cga 411 < 210 > 32 < 211 > 96 < 212 > PRT < 213 > Corynebacterium glutamicum 15 < 400 > 32 Val Tyr Pro Wing Glu Val Glu Glu Val Leu Wing Glu His Pro Asp He 1 5 10 15 Glu Asp Ser Wing Val Val Gly He Pro Arg Glu Asp Gly Ser Glu Asn 20 25 30 Val Val Ala Wing He Thr Leu Val Glu Gly Ala Ala Leu Asp Pro Asp 35 40 45 Gly Leu Lys Glu Phe Ala Arg Lys Asn Leu Thr Arg Tyr Lys Val Pro 50 55 60 Arg Thr Phe Tyr His Phe Glu Glu Met Pro Arg Asp Gln Met Gly Lys 65 70 75 80 20 He Arg Arg Arg Glu Val Gln Ala Glu Leu Leu Lys Lys Leu Gly Lys 85 90 95 < 210 > 33 < 211 > 913 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (913) < 223 > FRXA02490 25 • - * «• **» '»» "- < 400 > 33 teatagetac, gcgcatgccc acattetaga tc < geeg; aaga aageageggg < acgtietetat 60 ataictaaagg, gcactaaaige aacgcagttig aaigggaicace atg tea gca tac gaa 115 Met Ser Ala Tyr Glu 1 5 acc aaa gaa tgg etc cag drops tac cca gag tgg acg cca drops tcg ctg 163 Thr Lys Glu Trp Leu Gln His Tyr Pro Glu Trp Thr Pro His Ser Leu 10 15 20 • gaa tat ggc gac acc acc ctg ctg gac gtt tac gac aac aac ctg gcc 211 Glu Tyr Gly Asp Thr Thr Leu Leu Asp Val Tyr Asp Asn Asn Leu Wing 25 30 35 att aac gca gac aag cca gcc acc tac ttt ttc ggt cgt tea caa acc 259 He Asn Wing Asp Lys Pro Wing Thr Tyr Phe Phe Gly Arg Ser Gln Thr 40 45 50 tac ggt gaa ctg gac aaa gaa gtc cgc aaa act gcc gct gcc ctg cgc 307 Tyr Gly Glu Leu Asp Lys Glu Val Arg Lys Thr Ala Wing Gly Leu Arg 55 60 65 gca cta ggt gtc cgc ccc ggc gat falls gta gcg att ate etc ccc aac 355 Wing Leu Gly Val Arg Pro Gly Asp His Val Wing He He Leu Pro Asn 70 75 80 85 tgc cca cag falls gca gct tcc tac gca gcg 10 gtg ctg aaa etc ggc gca 403 Cys Pro Gln His He Wing Wing Phe Tyr Wing Val Leu Lys Leu Gly Wing 90 95 100 gta gtc att gag falls aac ccg etc tac acc gcc falls gaa ctg etc gaa 451 • Val Val He Glu His Asn Pro Leu Tyr Thr Ala His Glu Leu Leu Glu 105 110 115 ccc ttc aaa gac falls ggt gcc cgc gtt gcc ate gtc tgg gac aaa gcc 499 Pro Phe Lys Asp His Gly Ala Arg Val Ala He Val Trp Asp Lys Wing 120 125 130 tcc ccc acc gtc gaa cag cta cgt gga cag acc cag ttg gaa acc ate 547 Ser Pro Thr Val Glu Gln Leu Arg Gly Gln Thr Gln Leu Glu Thr He 135 140 145 15 gtg tcg gtc aac atg ate aac gcg atg cca cca etc cag cgc cta gca 595 Val Ser Val Asn Met He Asn Wing Met Pro Pro Leu Gln Arg Leu Wing 150 155 160 165 ctt cgg etc cca ate ect gca ctg cgc aag age cgc gaa tcc etc tcc 643 Leu Arg Leu Pro He Pro Wing Leu Arg Lys Ser Arg Glu Ser Leu Ser 170 175 180 ggc gca gcc ccc aac acc gtt ect ttt gaa acc gt acc age gca gca 691 Gly Ala Ala Pro Asn Thr Val Pro Phe Glu Thr Leu Thr Ser Ala Ala • 185 190 195 atg ggc ggc gac ggc gac gata gta gta tea gaa ccc acc gtg acc aaa 739 Met Gly Gly Asp Gly Asp Asp Val Val Ser Glu Pro Thr Val Thr Lys 200 205 210 aa tcc gtc gcg ctg ate etc tac acc tcc ggc acc acc gga cgc ccc 787 20 g Glu Ser Val Ala Leu He Leu Tyr Thr Ser Gly Thr Thr Gly Arg Pro 215 220 225 aag ggt gcc cag etc acc fall gga aac ctg ttc tcc aat etc etc ca 835 Lys Gly Ala Gln Leu Thr His Gly Asn Leu Phe Ser Asn Leu Leu Gln 230 235 240 245 gga aag falls tgg gtt cca ggt etc gga gac aaa cca gaa cgc atg ctt 883 Gly Lys His Trp Val Pro Gly Leu Gly Asp Lys Pro Glu Arg Met Leu 250 255 260 gca gcc cta cca atg ttc falls gca tac ggt 913 Wing Ala Leu Pro Met Phe His Wing Tyr Gly 265 270 25 < 210 > 34 < 211 > 271 < 212 > PRT < 213 > Corynebacterium gluta icum < 400 > 34 Met Ser Wing Tyr Glu Thr Lys Glu Trp Leu Gln His Tyr Pro Glu Trp 1 5 10 15 Thr Pro His Ser Leu Glu Tyr Gly Asp Thr Thu Leu Leu Asp Val Tyr 20 25 30 Asp Asn Asn Leu Wing He Asn Wing Asp Lys Pro Ala Thr Tyr Phe Phe 35 40 45 Gly Arg Ser Gln Thr Tyr Gly Glu Leu Asp Lys Glu Val Arg Lys Thr 50 55 60 Wing Wing Gly Leu Arg Wing Leu Gly Val Arg Pro Gly Asp His Val Wing 65 70 75 80 He He Leu Pro Asn Cys Pro Gln His He Ala Ala Phe Tyr Ala Val 85 90 95 Leu Lys Leu Gly Ala Val Val He Glu His Asn Pro Leu Tyr Thr Ala 100 105 110 10 His Glu Leu Leu Glu Pro Phe Lys Asp His Gly Ala Arg Val Ala He 115 120 125 Val Trp Asp Lys Wing Pro Pro Thr Val Glu Gln Leu Arg Gly Gln Thr 130 135 140 • Gln Leu Glu Thr He Val Ser Val Asn Met He Asn Wing Met Pro Pro 145 150 155 160 Leu Gln Arg Leu Wing Leu Arg Leu Pro Wing Pro Wing Leu Arg Lys Ser 165 170 175 Arg Glu Ser Leu Ser Gly Wing Wing Pro Asn Thr Val Pro Phe Glu Thr 180 185 190 Leu Thr Ser Wing Wing Met Gly Gly Asp Gly Asp Asp Val Val Ser Glu 195 200 205 15 Pro Thr Val Thr Lys Glu Ser Val Wing Leu He Leu Tyr Thr Ser Gly 210 215 220 Thr Thr Gly Arg Pro Lys Gly Wing Gln Leu Thr His Gly Asn Leu Phe 225 230 235 240 Ser Asn Leu Leu Gln Gly Lys His Trp Val Pro Gly Leu Gly Asp Lys 245 250 255 Pro Glu Arg Met Leu Ala Ala Leu Pro Met Phe His Ala Tyr Gly 260 265 270 • < 210 > 35 < 211 > 414 < 212 > DNA 20 < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (391) < 223 > RXA01467 < 400 > 35 gcgtcatctt tagccttgct ttatgagctt ttccccgcaa tgageegegt tgtgtateca 60 taagtcttag cctacaagcg ctttgaggta gtttgggatc atg gat ttc aac gac 115 Met Asp Phe Asn Asp 1 5 2 ^ aaa gcc gct tea gaa aac gct gta aag act ggc gca gaa ggc ccc aac 163 - i TITIG íltflÉÉllf? írr Lys Ala Ala Ser Glu Asn Ala Val Lys Thr Gly Ala Glu Gly Pro Asn 10 15 20 gtt ttc gcg age gtg gcc aag att tg ggc ggc gga att tea 211 Val Phe Ala Ser Val Ala Lys He Leu Gln Asp Val Gly Gly Be Ser 25 30 35 gcc gaa gac gtc act ccg gaa tet cgt ttt act gag gat ttg gca gtg 259 Wing Glu Asp Val Thr Pro Glu Ser Arg Phe Thr Glu Asp Leu Wing Val 40 45 50 age tea etc aat tac ate gag ttg att gtc aat gcg gag gac gca ttt 307 Ser Ser Leu Asn Tyr He Glu Leu He Val Asn Wing Glu Asp Wing Phe 55 60 65 ggt gtt cgc att gag gac gcc gat gcc aag gat ttg acc acc gtg cag 355 Gly Val Arg He Glu Asp Wing Asp Wing Lys Asp Leu Thr Thr Val Gln 70 75 80 85 gat ttg att gac ttt att aac acc aat aag gct gat tagcgggaaa 401 Asp Leu He Asp Phe He Asn Thr Asn Lys Wing Asp 90 95 atttcgccca aaa 414 < 210 > 36 < 211 > 97 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 36 Met Asp Phe Asn Asp Lys Wing Wing Ser Glu Asn Wing Val Lys Thr Gly 1 5 10 15 Wing Glu Gly Pro Asn Val Phe Wing Ser Val Wing Lys He Leu Gln Asp 20 25 30 Val Gly Gly He Ser Wing Glu Asp Val Thr Pro Glu Ser Arg Phe Thr 35 40 45 Glu Asp Leu Wing Val Ser Ser Leu Asn Tyr He Glu Leu He Val Asn 50 55 60 Wing Glu Asp Wing Phe Gly Val Arg He Glu Asp Wing Asp Wing Lys Asp 65 70 75 80 Leu Thr Thr Val Gln Asp Leu He Asp Phe He Asn Thr Asn Lys Wing 85 90 95 Asp < 210 > 37 < 211 > 298 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (298) < 223 > RXA00796 < 400 > 37 ctggaatccc aaagcgcttg catgacgcgg aaagttaaca taggetaggt acgtcaagtt 60 gttgatacat caaettaatt aacttttaga ggagtacacc atg age aag ate gcc 115 Met Ser Lys He Ala 1 5 ate ate acc ggt tcc acc cgt cca ggc cgc gtc aac att gac gta gcc 163 He He Thr Gly Ser Thr Arg Pro Gly Arg Val Asn He Asp Val Wing 10 15 20 aac tgg gtt etc gag cgc gca cag gag cgc aac gat ga gc cag tac gag 211 Asn Trp Val Leu Glu Arg Wing Gln Glu Arg Asn Asp Wing Gln Tyr Glu 25 30 35 etc gtt gat gcc gat gt gat ttc aac ttc ccc gtc etc gac gaa gca atg 259 Leu Val Asp He Wing Asp Phe Asn Phe Pro Val Leu Asp Glu Wing Met 40 45 50 cca gcc ggc tac ggc cag tat gca aac gag drops acc aag 298 Pro Ala Gly Tyr Gly Gln Tyr Ala Asn Glu His Thr Lys 55 60 65 < 210 > 38 < 211 > 66 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 38 Met Ser Lys He Wing He He Thr Gly Ser Thr Arg Pro Gly Arg Val 1 5 10 15 Asn He Asp Val Wing Asn Trp Val Leu Glu Arg Wing Gln Glu Arg Asn 20 25 30 Asp Wing Gln Tyr Glu Leu Val Asp He Wing Asp Phe Asn Phe Pro Val 35 40 45 Leu Asp Glu Wing Met Pro Wing Gly Tyr Gly Gln Tyr Ala Asn Glu His 50 55 60 Thr Lys 65 < 210 > 39 < 211 > 666 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (643) < 223 > RXA01897 < 400 > 39 ctatttagat cgttccggaa ccgatccacg cgccgatatc cactccctgg atgaactctt 60 tcactaggct ggcctttatt gtttccggaa aggggttgct atg aaa att ggt gtc 115 Met Lys He Gly Val 1 5 ate ctg ggc agt ate cgc gaa ggc cgc ttc ggc ca ggc gtt gcc gat 163 He Leu Gly Be He Arg Glu Gly Arg Phe Gly Gln Gly Val Wing Asp 10 15 20 tgg gtc atg gaa caa ate ggg gct tat gac gca ccc gat gtg gaa ttt 211 Trp Val Met Glu Gln He Gly Wing Tyr Asp Wing Pro Asp Val Glu Phe 25 30 35 gaa etc ate gac etc aaa gct ttc aac gtg ccc ctg ttg gaa tcc gcg 259 Glu Leu He Asp Leu Lys Ala Phe Asn Val Pro Leu Leu Glu Ser Wing 40 45 50 here gtt cca ggt tcc gcg gat aaa cag tac gac gac ccg cgc gta act 307 Thr Val Pro Gly Ser Wing Asp Lys Gln Tyr Asp Asp Pro Arg Val Thr 55 60 65 gcc tgg tea cag gcc att gat gcc tgc gat gcc ttc ctt ttc ate acc 355 Wing Trp Ser Gln Wing He Asp Wing Cys Asp Wing Phe Leu Phe He Thr 70 75 80 85 ccg gaa tac aac drops ggt gtg ccc ggc gcg ttc aaa aat gcg tat gac 40: Pro Glu Tyr Asn His Gly Val Pro Gly Wing Phe Lys Asn Wing Tyr Asp 90 95 100 ate ctg ggc aat gaa tgg ctg aac aaa acc gtc ggt ttc att tcc tac 451 He Leu Gly Asn Glu Trp Leu Asn Lys Thr Val Gly Phe He Ser Tyr 105 110 115 ggt gca gtc gaa ggg ate cgt gtt gtc gaa cag ttgggg ccggtt cag ate gtc 499 Gly Wing Val Glu Gly He Arg Val Val Glu Gln T Trrpp A Arrgg Gln He Val 120 125 1 13300 gcc acc ttc aac tc c tc cc tc cc tc tccc ttacccc tttcccc ttcc acc 547 Wing Thr Phe Asn Met Tyr Asp He Arg Ser Gln L Leeuu S Seerr Phe Ser Thr 135 140 1 14455 ttc acc gag aac aac gcc act ttt gcg ccc aaaatt ggaatt cga cgc ccc 595 Phe Thr Glu Asn Asn Asn Gly Thr Phe Ala Pro A Assnn A Asspp Arg Arg Pro 150 155 160 165 ggt gaa cta ate cgc etc ctt gat age etc cta aaccgg ggcctt gtc cgc gat 643 Gly Glu Leu He Arg Leu Leu Asp Ser Leu Leu T Thhrr A Allaa Val Arg Asp 170 175 180 taaggctctg aaatactaat gag 666 10 < 210 > 40 < 211 > 181 < 212 > PRT < 213 > Corynebacterium glutamicum • < 400 > 40 Met Lys He Gly Val He Leu Gly Ser He Arg Glu Gly Arg Phe Gly 1 5 10 15 Gln Gly Val Wing Asp Trp Val Met Glu Gln He Gly Wing Tyr Asp Wing 20 25 30 Pro Asp Val Glu Phe Glu Leu He Asp Leu Lys Wing Phe Asn Val Pro 35 40 45 15 Leu Leu Glu Be Wing Thr Val Pro Gly Ser Wing Asp Lys Gln Tyr Asp 50 55 60 Asp Pro Arg Val Thr Wing Trp Ser Gln Wing He Asp Wing Cys Asp Wing 65 70 75 80 Phe Leu Phe He Thr Pro Glu Tyr Asn His Gly Val Pro Gly Wing Phe 85 90 95 Lys Asn Wing Tyr Asp He Leu Gly Asn Glu Trp Leu Asn Lys Thr Val 100 105 110 Gly Phe He Ser Tyr Gly Wing Val Glu Gly He Arg Val Val Glu Gln • 115 120 125 Trp Arg Gln He Val Wing Thr Phe Asn Met Tyr Asp He Arg Ser Gln 130 135 140 20 Leu Ser Phe Ser Thr Phe Thr Glu Asn Asn Asn Gly Thr Phe Wing Pro 145 150 155 160 Asn Asp Arg Arg Pro Gly Glu Leu He Arg Leu Leu Asp Ser Leu Leu 165 170 175 Thr Wing Val Arg Asp 180 < 210 > 41 < 211 > 375 < 212 > DNA < 213 > Corynebacterium glutamicum 25 < 220 > , - a t a * tM * MJa < 221 > CDS < 222 > ( 1 ) . . (375) < 223 > RXN02809 < 400 > 41 aac etc tcc gtc cca gca gca cta acc aac gcc ctt tcc tac etc tcc 48 Asn Leu Ser Val Pro Ala Ala Leu Thr Asn Ala Leu Ser Tyr Leu Ser 1 5 10 15 gca gag tgg aac aac aag gct gca ggc ate gtc tcc tac ggc tcc gca 96 Wing Glu Trp Asn Asn Lys Wing Wing Gly He Val Ser Tyr Gly Wing Wing 20 25 30 atg ggc gtt cgc gca gct gag drops etc cgc ggc ate ctt tcc gag ctt 144 Met Gly Val Arg Ala Ala Glu His Leu Arg Gly He Leu Ser Glu Leu 35 40 45 cag ate gca falls gtt caa aag acc ggc ctg ctg age ate ttc acc gac 192 Gln He Ala His Val Gln Lys Thr Gly Leu Leu Ser He Phe Thr Asp 50 55 60 ttc gaa tac ect aac ttc aag ect tcc gag cag ggc aattee ttcccc tteett ggttgg 240 Phe Glu Tyr Pro Asn Phe Lys Pro Ser Glu Gln Gly He Ser Ser Val 65 70 75 80 gac gct atg ctt gag cag ctt gtt gtc tgg acc aag ggccaa aattgg ttcccc aacccc 288 Asp Wing Met Leu Glu Gln Leu Val Val Trp Thr Lys AAllaa Met Ser Thr 85 90 95 att cgc gag tet gcg aac gtc tat cae tta aga acc eecctt ccaaee aaaaaa aaggtt 336 He Arg Glu Be Wing Asn Val Tyr His Leu Arg Thr PPrroo His Lys Ser 100 105 110 ggc gag etc ccc gac tgg gac tcg ect ctt ttc gta ttc 375 Gly Glu Leu Pro Asp Trp Asp Ser Pro Leu Phe Val Phe 115 120 125 < 210 > 42 < 211 > 125 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 42 Asn Leu Ser Val Pro Ala Ala Leu Thr Asn Ala Leu Ser Tyr Leu Ser 1 5 10 15 Ala Glu Trp Asn Asn Lys Ala Ala Gly He Val Ser Tyr Gly Ser Ala 20 25 30 Met Gly Val Arg Ala Ala Glu His Leu Arg Gly He Leu Ser Glu Leu 35 40 45 Gln He Ala His Val Gln Lys Thr Gly Leu Leu Ser He Phe Thr Asp 50 55 60 Phe Glu Tyr Pro Asn Phe Lys Pro Ser Glu Gln Gly He Ser Ser Val 65 70 75 80 Asp Wing Met Leu Glu Gln Leu Val Val Trp Thr Lys Wing Met Ser Thr 85 90 95 He Arg Glu Ser Wing Asn Val Tyr His Leu Arg Thr Pro His Lys Ser 100 105 110 Gly Glu Leu Pro Asp Trp Asp Ser Pro Leu Phe Val Phe 115 120 125 < 210 > 43 < 211 > 273 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (273; 1 < 223 > FRXA02809 < 400 > 43 gca gca cta acc aac gcc ctt tcc tac etc tcc gca gag tgg aac aac 48 Ala Ala Leu Thr Asn Ala Leu Ser Tyr Leu Ser Ala Glu Trp Asn Asn 1 5 10 15 aag gct gca ggc ate gtc tcc tac ggc tcc gca atg ggc gtt cgc gca 96 Lys Wing Wing Gly He Val Tyr Gly Wing Wing Met Gly Val Arg Wing 20 25 30 gct gag drops etc cgc ggc ate ctt tcc gag ctt cag ate gca falls gtt 144 Ala Glu His Leu Arg Gly He Leu Ser Glu Leu Gln He Wing His Val 35 40 45 caa aag acc ggc ctg ctg age ate ttc acc gac ttc gaa tac ect aac 192 Gln Lys Thr Gly Leu Leu Ser He Phe Thr Asp Phe Glu Tyr Pro Asn 50 55 60 ttc aag ect tce gag cag ggc ate tcc tet gtg gac gct atg ctt gag 240 Phe Lys Pro Ser Glu Gln Gly He Ser Ser Val Asp Ala Met Leu Glu 65 70 75 80 cag ctt gtt gtc tgg acc aag gca atg tcc acc 273 Gln Leu Val Val Trp Thr Lys Ala Met Ser Thr 85 90 < 210 > 44 < 211 > 91 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 44 Ala Ala Leu Thr Asn Ala Leu Ser Tyr Leu Ser Ala Glu Trp Asn Asn 1 5 10 15 Lys Ala Ala Gly He Val Ser Tyr Gly Ser Ala Met Gly Val Arg Ala 20 25 30 Ala Glu His Leu Arg Gly He Leu Ser Glu Leu Gln He Ala His Val 35 40 45 Gln Lys Thr Gly Leu Leu Ser He Phe Thr Asp Phe Glu Tyr Pro Asn 50 55 60 Phe Lys Pro Ser Glu Gln Gly He Ser Ser Val Asp Ala Met Leu Glu 65 70 75 80 Gln Leu Val Val Trp Thr Lys Ala Met Ser Thr 85 90 < 210 > 45 < 211 > 5745 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (5722) < 223 > RXN00113 < 400 > 45 tctgcgcatc ccactcgagg agctggcaaa cggccgcacc ategatgttg aggcacgcac 60 cgactccatc gaagagtccg catccggccg tatcgttacc gtg cgc ate gtg etc 115 Val Arg He Val Leu 1 5 acc acc gaa ggc gaa gta gca gcc aag ctg gtt acc cgc ttc gca att 163 Thr Thr Glu Gly Glu Val Ala Ala Lys Leu Val Thr Arg Phe Wing He 10 15 20 cgt gga cgc ate acc acac gaa atg gct gca cca gca gat tcc tac 211 Arg Gly Arg He Thr Thr Asn Glu Met Ala Wing Pro Wing Asp Ser Tyr 25 30 35 • ggc gca cgc gac gaa gtt gtc gag gca acc ect cgt tcc ctc tc ccc 259 Gly Wing Arg Asp Glu Val Val Glu Wing Thr Pro Arg Ser Phe He Arg 40 45 50 cag gca act gtt tet gca ect gca gac atc acc cca tcc gcc atg gtt 307 Gln Ala Thr Val Ser Wing Pro Wing Asp Met Thr Pro Phe Wing Met Val 55 60 65 tet ggt gac tac aac cca att falls acc tet gac aac gct gca aag ctt 355 Ser Gly Asp Tyr Asn Pro He His Thr Ser Asp Asn Ala Ala Lys Leu 70 75 80 85 gtt ggc ctg gac gc gct ctt gtc fall ggc atg tgg ctg ccc gct acc 403 Val Gly Leu Asp Ala Ala Leu Val His Gly Met Trp Leu Ser Ala Thr 10 90 95 100 gca cag drops etc gct ggt ctt ggc tet gag gtc att ggt tgg acc tac 451 Wing Gln His Leu Wing Gly Leu Gly Ser Glu Val He Gly Trp Thr Tyr 105 110 115 tcc atg tac ggc atg gtt caa etc aac gac gtt gtt gac ate acc gtc 499 Ser Met Tyr Gly Met Val Gln Leu Asn Asp Val Val Asp He Thr Val 120 125 130 gag cgt gtt ggc cgc gca ggt ctg aag ect gca tac gag gtc acc tgc 547 Glu Arg Val Gly Arg Ala Gly Leu Lys Pro Ala Tyr Glu Val Thr Cys 135 140 145 cgc at t gat ggc aac gtt gtc tcc cgc gga cag gca ctg etc aag gct 595 Arg He Asp Gly Asn Val Val Ser Arg Gly Gln Ala Leu Leu Lys Ala 15 150 155 160 165 ect tcc acc gct tat gtt tac cca age cag ggc ate cag gct aag ggc 643 Pro Ser Thr Wing Tyr Val Tyr Pro Ser Gln Gly He Gln Wing Lys Gly 170 175 180 atg ggc ca ggc gat cgc acc gca age gca gag gct cgc gct gtg tgg 691 Met Gly Gln Gly Asp Arg Thr Wing Ala Glu Ala Arg Ala Val Trp 185 190 195 gag cgt gca gat gca falls acc gg aac ctg ggc ttc tcc ate cag 739 Glu Arg Ala Asp Ala His Thr Arg Ala Asn Leu Gly Phe Ser He Gln 200 205 210 cag gtc att gat gaa aac cca act gag ctg aag gtc ggg gac acc acc 787 Gln Val He Asp Glu Asn Pro Thr Glu Leu Lys Val Gly Asp Thr Thr 20 215 220 225 ttc gtg falls cca gct ggg gtt ttg aac etc acc cag ttc acg cag gtc 835 phe Val His Pro Wing Gly Val Leu Asn Leu Thr Gln Phe Thr Gln Val 230 235 240 245 gcg etc gcc gtg gtt gcc tac gct cag acc gag cgc etc aag gct gca 883 Ala Leu Ala Val Val Ala Tyr Ala Gln Thr Glu Arg Leu Lys Ala Ala 250 255 260 aac gca att gtc gac ggc tcc etc tac gca ggc falls tcc etc ggc gag 931 Asn Ala He Val Asp Gly Ser Leu Tyr Ala Gly His Ser Leu Gly Glu 265 270 275 tac acc gca ctg gca tcc tgc ggc aac ate ttc gaa etc gaa ggc gtc 979 Tyr Thr Ala Leu Ala Ser Leu Gly Asn He Phe Glu Leu Glu Gly Val 25 280 285 290 ate gac gtt gtg ttc tcc cgc ggt tcc gca atg falls tcc ctg gtt cca 1027 He Asp Val Val Phe Ser Arg Gly Ser Wing Met His Ser Leu Val Pro 295 300 305 cgt gat gag aag ggc cgt tcc aac tac ggt ctt gcc gca tcc cgt ccg 1075 Arg Asp Glu Lys Gly Arg Ser Asn Tyr Gly Leu Wing Wing Phe Arg Pro 310 315 320 325 aac atg ate aac gtt gca gcc acc gag gtg gag aac tgg gtt gac cgt 1123 Asn Met He Asn Val Ala Ala Thr Glu Val Glu Asn Trp Val Asp Arg 330 335 340 gtc gct gaa gaa tcc ggc gaa ttc ctg cag ate gtt aac tac aac gtt 1171 Val Ala Glu Glu Ser Gly Glu Phe Leu Gln He Val Asn Tyr Asn Val 345 350 355 gat ggc cag cag tac gca gtc gca ggt acc ttg gct ggc ctg aag gcc 1219 Asp Gly Gln Gln Tyr Wing Val Wing Gly Thr Leu Wing Gly Leu Lys Wing 360 365 370 etc aag gct tet gca tet gca aac cca cgt gct tac gtg aac att cca 1267 Leu Lys Wing Being Wing Being Wing Asn Pro Arg Wing Tyr Val Asn He Pro 375 380 385 ggc att gac gtg cca ttc falls tcc age gtc ctg cgc cca ggc gtt ect 1315 Gly He Asp Val Pro Phe His Ser Ser Val Leu Arg Pro Gly Val Pro 390 395 400 405 gct ttc gca gag aag ctg gac gag ctg ctg cca gag acc ate gac att 1363 Ala Phe Ala Glu Lys Leu Asp Glu Leu Leu Pro Glu Thr He Asp He 410 415 420 gat gct ctt cgc ggc cgc tac ate ccg aac ctg gtt gct ccttct ttc 1411 Asp Ala Leu Arg Gly Arg Tyr He Pro Asn Leu Val Wing Arg Pro Phe 425 430 435 gag etc acc cag age ttc gtg gat gcc ate ctt gct gtt gtt cca ccc tcc 1459 Glu Leu Thr Gln Ser Phe Val Asp Wing He Leu Wing Val Val Pro Ser 440 445 450 gag cgc etc aag ggc ate aag gtg gag gac acc gac gag aac acc ctg 1507 Glu Arg Leu Lys Gly He Lys Val Glu Asp Thr Asp Glu Asn Thr Leu 455 460 465 gca cgt ctg etc etc ate gag ctg ctg tet tgg cag ttc gca tcc ect 1555 Wing Arg Leu Leu Leu He Glu Leu Leu Ser Trp Gln Phe Wing Pro Pro 470 475 480 485 gtg cgt tgg ate gaa acc gg cact gct ctg ate ate gat gtc gat cag 1603 Val Arg Trp He Glu Thr Gln Wing Leu He He Asp Thr Val Asp Gln 490 495 500 ate ate gag gtc ggc ttg gca gca tcg cca acc ctg acc aac ctg gca 1651 He He Glu Val Gly Leu Ala Wing Pro Thr Leu Thr Asn Leu Wing 505 510 515 ctc cgc acc atg gat gtc att ggc aag tcc cgc cca gta ttc aac gtg 1699 Leu Arg Thr Met Asp Val He Gly Lys Ser Arg Pro Val Phe Asn Val 520 525 530 gag cgc gac cag gac acc gtt atg etc aac gat gtt cgc cag gca ect 1747 Glu Arg Asp Gln Asp Thr Val Met Leu Asn Asp Val Arg Gln Wing Pro 535 540 545 gtt gag gtt gaa gaa gaa gca gtt gag gaa gca ect gca gca gcc 1795 Val Glu Wing Val Glu Glu Glu Wing Val Glu Glu Wing Pro Wing Wing Wing 550 555 560 565 gca gct cca gca gct gac gca cca gtt gct gca gct cca gta gcc gca 1843 Wing Wing Pro Wing Wing Glu Wing Pro Val Wing Wing Pro Val Wing Wing 570 575 580 gcc gca ect gca ect gtt gga aac gca ect gaa ctg aag ttc aac gct 1891 Wing Wing Pro Wing Pro Val Gly Asn Wing Pro Glu Leu Lys Phe Asn Wing 585 590 595 - * «& gcc aat gcc ate atg gtt etc ttc gct gtc cag aac aag ate aac att 1939 Ala Asn Ala He Met Val Leu Phe Ala Val Gln Asn Lys He Asn He 600 605 610 gat cag ate acc gca gcg gat acc tet gag acc ctg acc aac ggt gtg 1987 Asp Gln He Thr Wing Wing Asp Thr Ser Glu Thr Leu Thr Asn Gly Val 615 620 625 tcc tea cgc cgt aac cag atg etc atg gac atg tcc acc gag ctg tcc 2035 Being Ser Arg Arg Asn Gln Met Leu Met Asp Met Ser Thr Glu Leu Ser 630 635 640 645 gtc cca acc ate gac ggc gca gct gac gct gac gta gct acc ctg cag 2083 Val Pro Thr He Asp Gly Wing Wing Asp Wing Asp Val Wing Thr Leu Gln 650 655 660 gga cgt gtt gtc acc gca gct ect ggc tac aag ect ttc gga cca gtt 2131 Gly Arg Val Val Thr Wing Ala Pro Gly Tyr Lys Pro Phe Gly Pro Val 665 670 675 ctt tcc gag acc gtt cgt gca cgt ctt cgc gca ctg acc ggt gca gca 2179 Leu Ser Glu Thr Val Arg Wing Arg Leu Arg Wing Leu Thr Gly Wing Wing 680 685 690 ggt ctg aag acc tcc tac ate ggc gat cgc gtg acc ggc acc tgg gga 2227 Gly Leu Lys Thr Ser Tyr He Gly Asp Arg Val Thr Gly Thr Trp Gly 695 700 705 ctt cca gaa age tgg acc gca falls gtt gag gtt gaa ttg ctg ctg ggc 2275 Leu Pro Glu Ser Trp Thr Ala His Val Glu Val Glu Leu Leu Leu Gly 710 715 720 725 acc cgc gaa ggc gag tcc gtc cgc ggc ggc aac ctg ggt age ctg ect 2323 Thr Arg Glu Gly Glu Ser Val Arg Gly Gly Asn Leu Gly Ser Leu Pro 730 735 740 gct aac gca tcc age aag ggc gac gtc gat gcg ctt ate gac gca gcc 2371 Wing Asn Wing Being Ser Lys Gly Asp Val Asp Wing Leu He Asp Wing Wing 745 750 755 gtg cag aat gtt gct gca gcc aac ggc acc age gtc tcc atg tcc tcc 2419 Val Gln Asn Val Wing Wing Wing Asn Gly Thr Ser Val Ser Met Ser Ser 760 765 770 ggc ggt gca gct ggt tea ggt gga gtt gtt gat gcc tcc gca gtt ctt gat 2467 Gly Gly Wing Wing Gly Gly Gly Val Val Asp Wing Wing Ala Leu Asp 775 780 785 gcc tac gca tcc acc gtc act ggt gaa ggc gtc gtc ctg gca aac gtt 2515 Wing Tyr Wing Ser Thr Val Thr Gly Glu Glu Gly Val Leu Wing Asn Val 790 795 800 805 gct cgc ggc ate ctg tet cag ctt ggt etc gac acc aag gac gag gtt 2563 Wing Arg Gly He Leu Ser Gln Leu Gly Leu Asp Thr Lys Asp Glu Val 810 815 820 gaa ggc gca gag ate gac acc gaa etc tac gac gct gtc gaa gca gaa 2611 Glu Gly Wing Glu He Asp Thr Glu Leu Tyr Asp Wing Val Glu Wing Glu 825 830 835 ctg ggc acc ggc tgg ctg aag ctt gtc acc cca gtg ttc tcc gct gat 2659 Leu Gly Thr Gly Trp Leu Lys Leu Val Thr Pro Val Phe Ser Wing Asp 840 845 850 cgt gcg ate ttg ttc gac gac cgt tgg gca tet gca cgt gaa gat ctg 2707 Arg Ala He Leu Phe Asp Asp Arg Trp Wing Being Wing Arg Glu Asp Leu 855 860 865 gca cgc ctt gcc aac ggc gag gat att gcc gtc gag cgc ttt gct gga 2755 Wing Arg Leu Wing Asn Gly Glu Asp He Wing Val Glu Arg Phe Wing Gly 870 875 880 885 acg ggg gag acc gtc gtc aag ca gct gca tgg tgg gct gag falls gtt 2803 Thr Gly Glu Thr Val Val Lys Gln Ala Wing Trp Trp Wing Glu His Val 890 895 900 tli-, J '"- < * •'" * gaa gac acc gct etc gct gca acc ctg aag cag gtt tcc gag gtg gct 2851 Glu Asp Thr Ala Leu Ala Ala Thr Leu Lys Gln Val Ser Glu Val Wing 905 910 915 gcg aag cca gcc aac gag cca cae ate gac gat gtt gcg ctg gtt acc 2899 Wing Lys Pro Wing Asn Glu Pro His He Asp Asp Val Wing Leu Val Thr 920 925 930 ggt gcg gct ect gag tcg ate gcc ggt gca gtt gcg gct cgc ctg ctg 2947 Gly Wing Wing Pro Glu Be Wing Wing Gly Wing Val Wing Wing Arg Leu Leu 935 940 945 tcc cag ggc gcg acc gtc att etc acc gca tcg aac gtc tcc cag gcg 2995 Ser Gln Gly Ala Thr Val He Leu Thr Ala Ser Asn Val Ser Gln Ala 950 955 960 965 cgt aag gaa tac gca cgc aag etc tac gct gcg aac gca acc ect aac 3043 Arg Lys Glu Tyr Wing Arg Lys Leu Tyr Wing Wing Asn Wing Thr Pro Asn 970 975 980 gca aag ctg tgg att gtt ect gcg aac atg tcc tcc tac cgc gat gtt 3091 Wing Lys Leu Trp He Val Pro Wing Asn Met Ser Ser Tyr Arg Asp Val 985 990 995 gat gca gtc ate gat tgg ate ggc aac gag cag cgc gtc acc gtc < Asp Ala Val He Asp Trp He Gly Asn Glu Gln Arg Val Thr Val (Gly 1000 1005 1010 age acc gtc acc gtg acc aag cca gct ctg acc cca acc ctt gcg tac 3187 Ser Thr Val Thr Val Thr Lys Pro Ala Leu Thr Pro Thr Leu Ala Tyr 1015 1020 1 1002255 cca ttttct; ggcca £ a ggcdt: ccccaa tcc gta tcc ggt acc ttg ggccgg ggaatt gca ggc cca 323 Pro PPhhe (3 AAlla; a AAllaea PPrroc Ser Val Ser Gly Thr Leu Ala Asp Ala Gly Pro 1030 1035 1040 1045 cag gct gaa aac cag gca cgc ctg etc etc tgg tcc gtg gag cgc acc 3283 Gln Ala Glu Asn Gln Ala Arg Leu Leu Leu Trp Ser Val Glu Arg Thr 1050 1055 1060 ate gca gga ctt gca gat ctt gca tcc cgc ggt gtc gat gga cgc gtc 3331 I have Wing Gly Leu A Allaa Asp Leu Wing Being Arg Gly Val Asp Gly Arg Val 1065 1070 1075 falls gtt gta etc cca ggt tcc ccg aac cgc gga atg ttc ggt ggc gac 3379 His Val Val Leu Pro Gly Ser Pro Asn Arg Gly Met Phe Gly Gly Asp 1080 1085 1090 ggc gct tac ggc gaa gtc aag gct gct tcc gac gcc ate ctt gcc aag 3427 Gly Wing Tyr Gly Glu Val Lys Wing Wing Phe Asp Wing He Leu Wing Lys 1095 1100 11110055 tgg ggc tcc gag acc ggc tgg cca cag ttt ggttcc ttcccc; eettcc gca cag gca 3475 Trp Gly Ser Glu Thr Gly Trp Pro Gln Phe VVaall SSeeir: LLeeuu Wing Gln Ala me) 1115 111122C0 1125 cgc ate ggc tgg gtc gca ggc acc ggc etc aattgg ggggtt ccggcc aac gac gtg 3523 Arg He Gly Trp Val Wing Gly Thr Gly Leu MMeett GGllyy AArrgg, Asn Asp Val 1130 1135 1140 eettcc aattee eecctt ggcccc ggcctt ggaaaa aaaagg ccttgg ggggcc aattee ccaaee ggttcc ttaacc acc ect gaa 3571 Leu He Pro Ala Ala Glu Lys Leu Gly He His Val Tyr Thr Pro Glu 1145 1150 1155 gag ate tet tcc gaa ctg ctg ggt ctt gca tcc gca gaa tcc cgc gaa 3619 Glu He Ser Ser Glu Leu Leu Gly Leu Ala Ser Ala Glu Ser Arg Glu 1160 1165 1170 aag gct ccttgg ggaaaa gcccaa ccccgg ate gat tac gac ctg acc ggt gga ctt tcc 3667 Lys Wing LLeeuu GGlluu AAllaa PPrroo He Asp Tyr Asp Leu Thr Gly Gly Leu Ser 1175 1180 1185 ggt ggc gta tcc ate gca gca gt gca gca tcc etc gag tcc gac gca 3715 Gly Gly Val Ser Wing Ala Ala Wing Wing Ala Leu Glu Ser Asp Wing 1190 1195 1200 1205 gta gag acc acc tet gca gca gaa gac acc ate aag gcg ctt cca tea 3763 Val Glu Thr Thr Ser Ala Ala Glu Asp Thr He Lys Ala Leu Pro Ser 1210 1215 1220 ect aag falls cca gag cag cca gtg ggc acg cca gtt gga gag gtc aag 3811 Pro Lys His Pro Glu Gln Pro Val Gly Thr Pro Val Gly Glu Val Lys 1225 1230 1235 gat gat etc gaa gac atg gtt gtc atg gtt ggc gtt ggc gaa gtc tcc 3859 Thr Asp Leu Glu Asp Met Val Val Met Val Gly Val Gly Glu Val Ser • 1240 1245 1250 tea tgg ggc tcc gga cgt acc cgc ttc gaa gct gag tac ggc ate cag 3907 Be Trp Gly Be Gly Arg Thr Arg Phe Glu Wing Glu Tyr Gly He Gln 1255 1260 1265 cgc gac ggc tcc gtt gac etc acc gca gca ggc gtc ctt gag ctt gca 3955 Arg Asp Gly Ser Val Asp Leu Thr Wing Wing Gly Val Leu Glu Leu Wing 1270 1275 1280 1285 tgg atg ggt ctg ate tcc tgg age gaa gat cca aag cca gcc tgg 4003 Trp Met Met Gly Leu He Ser Trp Ser Glu Asp Pro Lys Pro Wing Trp 1290 1295 1300 tac gac gct gac ggc acc gaa gtg ect gaa gag ate tac gag cgc 4051 Tyr Asp Wing Asp Gly Thr Glu Val Pro Glu Glu Glu He Tyr Glu Arg 1305 1310 1315 10tc cgc gac gac gtc ate gca cga tgc ggt gtt cgt gag ctt gtc gac 4099 phe arg asp glu val he wing arg cys gly val arg glu leu val asp 1320 1325 1330 gac gca ttc etc. gtc gac ggc ggc tcc 4147 Asc Wing Phe Leu Val Asp Gly Gly Ser Leu Asp Ala Wing Glu Val Phe 1335 1340 1345 etc gac cgc gac ate tcc ttc tcc gta acc tet gct gaa gaa gca cag 4195 Leu Asp Arg Asp He Ser Phe Ser Val Thr Ser Wing Glu Glu Wing Gln 1350 1355 1360 1365 gcc tac gtc gat gca gat gct tcc gtg acc gtt gaa gaa gca gac ggc 4243 Wing Tyr Val Asp Wing Asp Wing Ser Val Thr Val Glu Glu Wing Asp Gly 1375 15 1370 1380 gaa tgg ate gtg acc aag aag ggc tcc acc tcc tcc cca ccc 4291 Glu Trp He Val Thr Lys Lys Lys Gly Ser Thr Ser Phe Val Pro Arg 1385 1390 1395 aag gca acc ctg acc cgc tcc gta gca ggc cag ctg cca acc gac ttc 4339 Lys Wing Thr Leu Thr Arg Ser Val Wing Gly Gln Leu Pro Thr Asp Phe 1400 1405 1410 gac ect gcc aag tgg ggt ate cca gcc tcc atg ate gat gca etc gac 4387 Asp Pro Wing Lys Trp Gly He Pro Wing Ser Met He Asp Wing Leu Asp 1415 1420 1425 aac ate gca gcg tgg aac ctg gtc act gca gtc gac gcc ttc ctg tcc 4435 Asn He Ala Wing Trp Asn Leu Val Thr Wing Val Asp Wing Phe Leu Ser 20 1430 1435 1440 1445 tcc gcc ttc age < : ca gca gaa etc ctg cag tcc ate cae cca gct gac 4483 Be Gly Phe Ser 1 Pro Wing Glu Leu Leu Gln Ser He His Pro Wing Asp L450 1455 1460 gtg tcc tcc acc ggc acc ggt ate ggt atg ggc atg cag tcc cta cgc 4531 Val Ser Ser Thr Gln Gly Thr Gly He Gly Gly Met Gln Ser Leu Arg 1465 1470 1475 aag ctg ttc gtc aac cgc ttc etc ggc cag gat cgt cca tcc gac ate 4579 Lys Leu Phe Val Asn Arg Phe Leu Gly Gln Asp Arg Pro Ser Asp He 1480 1485 1490 etc cag gag acc ctg cca aac gtt gtg gct gca falls acc atg cag tcc 4627 Leu Gln Glu Thr Leu Pro Asn Val Val Wing Wing His Thr Met Gln Ser 25 1495 1500 1505 tac gtc ggt ggc tac ggc cag atg ate drops cca gtg gca gca tgt gca 4675 Tyr Val Gly Gly Tyr Gly Gln Met He His Pro Val Ala Ala Cys Ala 1510 1515 1520 1525 acc gca gct gtc tcc gtg gaa gaa ggc gtg gac aag ate cgc etc aac 4723 Thr Wing Wing Val Ser Val Glu Glu Gly Val Asp Lys He Arg Leu Asn 1530 1535 1540 aag gca gat ttc gtt gtc gcc ggt ggt ate gat gac ate cag gtt gaa 4771 Lys Wing Asp Phe Val Val Wing Gly Gly He Asp Asp He Gln Val Glu 1545 1550 1555 tcc ctg acc ggc ttc ggt gac atg aac gcc acc gca gac acc cag gca 4819 Be Leu Thr Gly Phe Gly Asp Met Asn Wing Thr Wing Asp Thr Gln Wing 1560 1565 1570 atg ctg gac aag ggc ate gac cca cgc ttc ate tcc cgc gca aac gat 4867 Met Leu Asp Lys Gly He Asp Pro Arg Phe He Ser Arg Ala Asn Asp 1575 1580 1585 cga cgc cgc gca ggc ttc etc gaa gca ggt ggt ggt gtc acc gtc etc 4915 Arg Arg Arg Wing Gly Phe Leu Glu Wing Wing Gly Gly Gly Thr Val Leu 1590 1595 1600 1605 ctg gca cgt gca ct gtt gtt gct gt gaa ctg gga ctg cca gtt etc gca 4963 Leu Ala Arg Ala Ser Ala Ala Ala Glu Leu Gly Leu Pro Val Leu Ala 1610 1615 1620 gtt gtt gca falls gca cag tcc tac gcc gat ggt gct falls acc tcc ate 5011 Val Val Ala His Ala Gln Ser Tyr Wing Asp Gly Wing His Thr Ser He 1625 1630 1635 cca gca ccg gga ctt ggc gca ctg ggt gca gca cgt ggt ggc aag aag 5059 Pro Wing Pro Gly Leu Gly Wing Leu Gly Wing Wing Arg Gly Gly L? S Lys 1640 1645 1650 tcc gta ctt gct cgc gaa ctg aac aaa ttg ggt ctg acc cca gat gac 5107 Ser Val Leu Ala Arg Glu Leu Asn Lys Leu Gly Leu Thr Pro Asp Asp 1655 166C) 1665 gtt cgc gtg gtc tcg aag falls gac acc tcc acc aac gcc aac gat cca 5155 Val Arg Val Val Ser Lys Hà £ > Asp Thr Ser Thr Asn Ala Asn Asp Pro 1670 1675 1680 1685 aac gag tcc gag ctg falls aac ctg ctg tgg aag acc att gga cgc gaa 5203 Asn Glu Be Glu Leu His Asn Leu Leu Trp Lys Thr He Gly Arg Glu 1690 1695 1700 gcc gac aac ccg atg ttc gtc gtc tcc cag aag tcc ctt acc gga cae 5251 Wing Asp Asn Pro Met Phe Val Val Ser Gln Lys Ser Leu Thr Gly His 1705 1710 1715 tea aag ggc ggc gca gca etc ttc cag ate ggt gga ctt gtc tcc ate 5299 Be Lys Gly Gly Ala Ala Leu Phe Gln He Gly Gly Leu Val Ser He 1720 1725 1730 ctg gaa acc ggc aag ctg cca cag aac gca tcc ctt gac tgc gtt gac 5347 Leu Glu Thr Gly Lys Leu Pro Gln Asn Wing Ser Leu Asp Cys Val Asp 173E 174C 1 1745 cca gacj atg gaa gca aag ggc: gag aac ttc gtc tgg ctg cgc aag cca 5395 Pro Glu Met Glu Ala Lys Gl > 'Glu Asn Phe Val Trp Leu Arg Lys Pro 1750 1760 1765 ctg gat etc ggc gca ggc gta ctt acc tea ctg 5443 Leu Asp Leu Gly Wing Gly Val Leu Thr Ser Leu 1770 1775 1780 ggc ttc ggc drops gtg gct gca gtc gtc gtg ctg gca acc age ggc ate 5491 Gly Phe Gly His Val Wing Wing Val Val Val Leu Wing Thr Ser Gly He 1785 1790 1795 tcc gag cag gca atg cgc aac gca ggc etc gac gtc gaa gca tgg cgt 5539 Phe Glu Gln Ala Met Arg Asn Ala Gly Leu Asp Val Glu Ala Trp Arg 1800 1805 1810 gca cgc gca acc cag cgc ctg cgc acc ggt gca aac cgc cta gaa gct 5587 Ala Arg Ala Thr Gln Arg Leu Arg Thr Gly Ala Asn Arg Leu Glu Ala 1815 1820 1825 ggc atg gtt ggc gca cga cca ttg ttc gag cag gtc gac gga cgt cgc 5635 Gly Met Val Gly Arg Ala Pro Leu Phe Glu Gln Val Asp Gly Arg Arg 1830 1835 1840 1845 ctg cca gag cat ggc gct falls caá gca gag ate aac ttg ctt ate gac 5683 Leu Pro Glu His Gly Ala His Gln Ala Glu He Asn Leu Leu He Asp 1850 1855 1860 gct gac gct cgc etc ggt gct gac ggc ate tac cag ggc taaacgttag 5732 Ala Asp Ala Arg Leu Gly Ala Asp Gly He Tyr Gln Gly 1865 1870 atagetaaga aag 5745 < 210 > 46 < 211 > 1874 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 46 O Val Arg He Val Leu Thr Thr Glu Gly Glu Val Wing Wing Lys Leu Val 1 5 10 15 Thr Arg Phe Wing He Arg Gly Arg He Thr Thr Asn Glu Met Wing Wing 20 25 30 Pro Wing Asp Ser Tyr Gly Wing Arg Asp Glu Val Val Glu Ala Thr Pro 35 40 45 Arg Ser Phe He Arg Gln Wing Thr Val Ser Wing Pro Wing Asp Met Thr 50 55 60 Pro Phe Wing Met Val Ser Gly Asp Tyr Asn Pro He His Thr Ser Asp 65 70 75 80 Asn Ala Ala Lys Leu Val Gly Leu Asp Ala Ala Leu Val His Gly Met 85 90 95 Trp Leu Ser Ala Thr Ala Gln His Leu Ala Gly Leu Gly Ser Glu Val 100 105 110 He Gly Trp Thr Tyr Ser Met Tyr Gly Met Val Gln Leu Asn Asp Val 115 120 125 Val Asp He Thr Val Glu Arg Val Gly Arg Wing Gly Leu Lys Pro Wing 130 135 140 Tyr Glu Val Thr Cys Arg He Asp Gly Asn Val Val Ser Arg Gly Gln 145 150 155 160 Ala Leu Leu Lys Ala Pro Ser Thr Wing Tyr Val Tyr Pro Ser Gln Gly 165 170 175 He Gln Wing Lys Gly Met Gly Gln Gly Asp Arg Thr Wing Wing Wing Glu 180 185 190 Wing Arg Wing Val Trp Glu Arg Wing Asp Wing His Thr Arg Wing Asn Leu 195 200 205 Gly Phe Ser He Gln Gln Val He Asp Glu Asn Pro Thr Glu Leu Lys 210 215 220 Val Gly Asp Thr Thr Phe Val His Pro Wing Gly Val Leu Asn Leu Thr 225 230 235 240 Gln Phe Thr Gln Val Wing Leu Wing Val Val Wing Tyr Ala Gln Thr Glu 245 250 255 Arg Leu Lys Ala Ala Asn Ala He Val Asp Gly Ser Leu Tyr Ala Gly 260 265 270 His Ser Leu Gly Glu Tyr Thr Ala Leu Ala Ser Leu Gly Asn He Phe 275 280 285 Glu Leu Glu Gly Val He Asp Val Val Phe Ser Arg Gly Be Ala Met »* -1 - * - * • -» - 290 295 300 His Ser Leu Val Pro Arg Asp Glu Lys Gly Arg Ser Asn Tyr Gly Leu 305 310 315 320 Ala Ala Phe Arg Pro Asn Met He Asn Val Ala Ala Thr Glu Val Glu 325 330 335 Asn Trp Val Asp Arg Val Ala Glu Glu Ser Gly Glu Phe Leu Gln He 340 345 350 Val Asn Tyr Asn Val Asp Gly Gln Gln Tyr Ala Val Wing Gly Thr Leu 355 360 365 • Wing Gly Leu Lys Wing Leu Lys Wing Being Wing Being Wing Asn Pro Arg Wing 370 375 380 Tyr Val Asn He Pro Gly He Asp Val Pro Phe His Ser Ser Val Leu 385 390 395 400 Arg Pro Gly Val Pro Ala Phe Ala Glu Lys Leu Asp Glu Leu Leu Pro 405 410 415 Glu Thr He Asp He Asp Ala Leu Arg Gly Arg Tyr He Pro Asn Leu 420 425 430 Val Ala Arg Pro Phe Glu Leu Thr Gln Ser Phe Val Asp Ala He Leu 435 440 445 Wing Val Val Pro Ser Glu Arg Leu Lys Gly He Lys Val Glu Asp Thr 10 450 455 460 Asp Glu Asn Thr Leu Wing Arg Leu Leu Leu He Glu Leu Leu Ser Trp 465 470 475 480 Gln Phe Ala Ser Pro Val Arg Trp He Glu Thr Gln Ala Leu He He • 485 490 495 Asp Thr Val Asp Gln He He Glu Val Gly Leu Ala Wing Pro Thr 500 505 510 Leu Thr Asn Leu Ala Leu Arg Thr Met Asp Val He Gly Lys Ser Arg 515 520 525 Pro Val Phe Asn Val Glu Arg Asp Gln Asp Thr Val Met Leu Asn Asp 530 535 540 Val Arg Gln Ala Pro Val Ala Glu Val Glu Glu Glu Ala Val Glu Glu 15 545 550 555 560 Ala Pro Ala Ala Ala Ala Ala Ala Pro Ala Ala Glu Ala Pro Val Ala Ala 565 570 575 Ala Pro Val Ala Ala Ala Ala Pro Ala Pro Val Gly Asn Ala Pro Glu 580 585 590 Leu Lys Phe Asn Ala Ala Asn Ala He Met Val Leu Phe Wing Val Gln 595 600 605 Asn Lys He Asn He Asp Gln He Thr Wing Wing Asp T • hr Ser Glu Thr 610 615 620 ^ Leu Thr Asn Gly Val Ser Ser Arg Arg Asn Gln Met Leu Met Asp Met 625 630 635 640 Ser Thr Glu Leu Ser Val Pro Thr He Asp Gly Wing Wing Asp Wing Asp 20 645 650 655 Val Wing Thr Leu Gln Gly Arg Val Val Thr Wing Wing Pro Gly Tyr Lys 660 665 670 Pro Phe Gly Pro Val Leu Ser Glu Thr Val Arg Ala Arg Leu Arg Ala 675 680 685 Leu Thr Gly Ala Wing Gly Leu Lys Thr Ser Tyr He Gly Asp Arg Val 690 695 700 Thr Gly Thr Trp Gly Leu Pro Glu Ser Trp Thr Wing His Val Glu Val 705 710 715 720 Glu Leu Leu Leu Gly Thr Arg Glu Gly Glu Ser Val Arg Gly Gly Asn 725 730 735 Leu Gly Ser Leu Pro Wing Asn Wing Being Ser Lys Gly Asp Val Asp Wing 25 740 745 750 Leu He Asp Ala Ala Val Gln Asn Val Ala Ala Ala Asn Gly Thr Ser 755 760 765 Val Ser Met Ser Ser Gly Gly Wing Wing Ser Gly Gly Val Val Asp 770 775 780 Ser Ala Ala Leu Asp Ala Tyr Ala Ser Thr Val Thr Gly Glu Glu Glu 785 790 795 800 Val Leu Wing Asn Val Wing Arg Gly He Leu Ser Gln Leu Gly Leu Asp 805 810 815 Thr Lys Asp Glu Val Glu Gly Wing Glu He Asp Thr Glu Leu Tyr Asp 820 825 830 Ala Val Glu Ala Glu Leu Gly Thr Gly Trp Leu Lys Leu Val Thr Pro 835 840 845 Val Phe Ser Wing Asp Arg Wing He Leu Phe Asp Asp Arg Trp Wing Ser 850 855 860 Wing Arg Glu Asp Leu Wing Arg Leu Wing Asn Gly Glu Asp He Wing Val 865 870 875 880 Glu Arg Phe Wing Gly Thr Gly Glu Thr Val Val Lys Gln Wing Wing Trp 885 890 895 Trp Wing Glu His Val Glu Asp Thr Wing Leu Wing Wing Thr Leu Lys Gln 900 905 910 Val Ser Glu Val Wing Wing Lys Pro Wing Asn Glu Pro His He Asp Asp 915 920 925 Val Wing Leu Val Thr Gly Wing Wing Pro Glu Ser Wing Wing Gly Wing Val 930 935 940 Wing Wing Arg Leu Leu Ser Gln Gly Wing Thr Val He Leu Thr Ala Ser 945 950 955 960 Asn Val Ser Gln Wing Arg Lys Glu Tyr Wing Arg Lys Leu Tyr Wing Wing 965 970 975 Asn Wing Thr Pro Asn Wing Lys Leu Trp He Val Pro Wing Asn Met Ser 980 985 990 Ser Tyr Arg Asp Val Asp Wing Val He Asp Trp He Gly Asn Glu Gln 995 1000 1005 Arg Val Thr Val Gly Ser Thr Val Thr Val Thr Lys Pro Wing Leu Thr 1010 1015 1020 Pro Thr Leu Wing Tyr Pro Phe Wing Wing Pro Ser Val Gly Thr Leu 1025 1030 1035 1040 Wing Asp Wing Gly Pro Gln Wing Glu Asn Gln Wing Arg Leu Leu Leu Trp 1045 1050 1055 Ser Val Glu Arg Thr He Wing Gly Leu Wing Asp Leu Wing Ser Arg Gly 1060 1065 1070 Val Asp Gly Arg Val His Val Val Leu Pro Gly Pro Pro Asn Arg Gly 1075 1080 1085 Met Phe Gly Gly Asp Gly Wing Tyr Gly Glu Val Lys Wing Wing Phe Asp 1090 1095 1100 Wing He Leu Wing Lys Trp Gly Ser Glu Thr Gly Trp Pro Gln Phe Val 1105 1110 1115 1120 Be Leu Ala Gln Ala Arg He Gly Trp Val Ala Gly Thr Gly Leu Met 1125 1130 1135 Gly Arg Asn Asp Val Leu He Pro Ala Ala Glu Lys Leu Gly He His 1140 1145 1150 Go l Tyr Thr Pro Glu Glu Be Ser Glu Leu Leu Gly Leu Wing Ser 1155 1160 1165 Wing Glu Be Arg Glu Lys Wing Leu Glu Wing Pro As Asp Tyr Asp Leu 1170 1175 1180 Thr Gly Gly Leu Ser Gly Gly Val Ser Wing Wing Leu Ala Ala Ser 1185 1190 1195 1200 Leu Glu Ser Asp Ala Val Glu Thr Thr Ser Ala Ala Glu Asp Thr He ^^^^ "* * -» »a» aM 1205 1210 1215 Lys Ala Leu Pro Pro Pro Lys His Pro Glu Gln Pro Val Gly Thr Pro 1220 1225 1230 Val Gly Glu Val Lys Thr Asp Leu Glu Asp Met Val Val Met Val Gly 1235 1240 1245 Val Gly Glu Val Ser Ser Trp Gly Ser Gly Arg Thr Arg Phe Glu Wing 1250 1255 1260 Glu Tyr Gly He Gln Arg Asp Gly Ser Val Asp Leu Thr Ala Wing Gly • 1265 1270 1275 1280 Val Leu Glu Leu Wing Trp Met Met Gly Leu He Ser Trp Ser Glu Asp 1285 1290 1295 Pro Lys Pro Wing Trp Tyr Asp Wing Asp Gly Thr Glu Val Pro Glu Glu 1300 1305 1310 Glu He Tyr Glu Arg Phe Arg Asp Glu Val He Wing Arg Cys Gly Val 1315 1320 1325 Arg Glu Leu Val Asp Asp Wing Phe Leu Val Asp Gly Gly Ser Leu Asp 1330 1335 1340 Wing Wing Glu Val Phe Leu Asp Arg Asp He Ser Phe Ser Val Thr Ser 1345 1350 1355 1360 Wing Glu Glu Wing Gln Wing Tyr Val Asp Wing Asp Wing Ser Val Thr Val 10 1365 1370 1375 Glu Glu Wing Asp Gly Glu Trp He Val Thr Lys Lys Lys Gly Ser Thr 1380 1385 1390 Ser Phe Val Pro Arg Lys Wing Thr Leu Thr Arg Ser Val Wing Gly Gln 1395 1400 1405 Leu Pro Thr Asp Phe Asp Pro Wing Lys Trp Gly He Pro Wing Wing Met 1410 1415 1420 He Asp Wing Leu Asp Asn He Wing Wing Trp Asn Leu Val Thr Wing Val 1425 1430 1435 1440 Asp Wing Phe Leu Ser Ser Gly Phe Ser Pro Wing Glu Leu Leu Gln Ser 1445 1450 1455 He His Pro Wing Asp Val Ser Ser Thr Gln Gly Thr Gly He Gly Gly 15 1460 1465 1470 Met Gln Ser Leu Arg Lys Leu Phe Val Asn Arg Phe Leu Gly Gln Asp 1475 1480 1485 Arg Pro Ser Asp He Leu Gln Glu Thr Leu Pro Asn Val Val Wing Wing 1490 1495 1500 His Thr Met Gln Ser Tyr Val Gly Gly Tyr Gly Gln Met He His Pro 1505 1510 1515 1520 Val Wing Wing Cys Wing Thr Wing Wing Val Ser Val Glu Glu Val Val • 1525 1530 1535 Lys He Arg Leu Asn Lys Wing Asp Phe Val Val Wing Gly Gly He Asp 1540 1545 1550 Asp He Gln Val Glu Ser Leu Thr Gly Phe Gly Asp Met Asn Wing Thr 20 1555 1560 1565 Wing Asp Thr Gln Wing Met Leu Asp Lys Gly He Asp Pro Arg Phe He 1570 1575 1580 Ser Arg Wing Asn Asg Arg Arg Arg Wing Gly Phe Leu Glu Wing Wing Gly 1585 1590 1595 1600 Gly Gly Thr Val Leu Leu Wing Arg Ala Ser Val Ala Ala Glu Leu Gly 1605 1610 1615 Leu Pro Val Leu Ala Val Val Ala Ala Ala Gln Ser Tyr Ala Asp Gly 1620 1625 1630 Ala His Thr Ser He Pro Ala Pro Gly Leu Gly Ala Leu Gly Ala Ala 1635 1640 1645 Arg Gly Gly Lys Lys Ser Val Leu Wing Arg Glu Leu Asn Lys Leu Gly 25 1650 1655 1660 ^ g ^ ggÉBtag || ¡^^^^^? ^ Leu Thr Pro Asp Asp Val Arg Val Val Ser Lys His Asp Thr Ser Thr 1665 1670 1675 1680 Asn Wing Asn Pro Asn Glu Ser Glu Leu His Asn Leu Leu Trp Lys 1685 1690 1695 Thr He Gly Arg Glu Wing Asp Asn Pro Met Phe Val Val Ser Gln Lys 1700 1705 1710 Ser Leu Thr Gly His Ser Lys Gly Ala Ala Ala Phe Gln He Gly 1715 1720 1725 Gly Leu Val Ser He Leu Glu Thr Gly Lys Leu Pro Gln Asn Wing 1730 1735 1740 Leu Asp Cys Val Asp Pro Glu Met Glu Ala Lys Gly Glu Asn Phe Val 1745 1750 1755 1760 Trp Leu Arg Lys Pro Leu Asp Leu Gly Wing Gly Ser He Lys Wing Gly 1765 1770 1775 Val Leu Thr Ser Leu Gly Phe Gly His Val Ala Ala Val Val Val Leu 1780 1785 1790 Ala Thr Ser Gly He Phe Glu Gln Ala Met Arg Asn Ala Gly Leu Asp 1795 1800 1805 Val Glu Ala Trp Arg Ala Arg Ala Thr Gln Arg Leu Arg Thr Gly Ala 1810 1815 1820 Asn Arg Leu Glu Wing Gly Met Val Gly Arg Wing Pro Leu Phe Glu Gln 1825 1830 1835 1840 Val Asp Gly Arg Arg Leu Pro Glu His Gly Wing His Gln Wing Glu He 1845 1850 1855 Asn Leu Leu He Asp Wing Asp Wing Arg Leu Gly Wing Asp Gly He Tyr 1860 1865 1870 Gln Gly < 210 > 47 < 211 > 3317 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (3294) < 223 > FRXA00113 < 40 (D > 47 gct tea ggt ggc gga gtt gtt gat tcc gca gca ctt gat gcc tac gca 48 Wing Being Gly Gly Gly Val Val Asp Being Wing Wing Leu Asp Wing Tyr Wing 1 5 10 15 tcc acc gtc act ggt gaa gag ggc gtc ctg gca aac gtt gct cgc ggc 96 Be Thr Val Thr Gly Glu Glu Gly Val Leu Wing Asn Val Wing Arg Gly 20 25 30 att ctg tet cag ctt ggt etc gac acc aag gac gag gtt gaa ggc gca 144 He Leu Ser Gln Leu Gly Leu Asp Thr Lys Asp Glu Val Glu Gly Wing 35 40 45 gag ate gac acc gaa etc tac gac gct gtc gaa gca gaa ctg ggc acc 192 Glu He Asp Thr Glu Leu Tyr Asp Wing Val Glu Wing Glu Leu Gly Thr 50 55 60 ggc tgg ctg aag ctt gtc acc cca gtg ttc tct gct gat cgt gcg ate 240 Gly Trp Leu Lys Leu Val Thr Pro Val Phe Ser Wing Asp Arg Ala He 65 70 75 80 ttg ttc gac gac cgt tgg gca tet gca cgt gaa gat ctg gca cgc ctt 288 Leu Phe Asp Asp Arg Trp Wing Being Wing Arg Glu Asp Leu Wing Arg Leu 85 90 95 ^^ sj ^^.? ^ s ^ »^ gcc aac ggc gag gat att gcc gtc gag cgc ttt gct gga acg ggg gag 336 Wing Asn Gly Glu Asp He Wing Val Glu Arg Phe Wing Gly Thr Gly Glu 100 105 110 acc gtc gtc aag ca gct gca tgg tgg gct gag falls gtt gaa gac acc 38'4 Thr Val Val Lys Gln Wing Wing Trp Trp Wing Glu His Val Glu Asp Thr 1 '115 120 125 gct etc gct gca acc ctg aag cag gtt tcc gag gtg gct gcg aag cca 432 Wing Leu Wing Wing Thr Leu Lys Gln Val Ser Glu Val Wing Wing Lys Pro 130 135 140 • gcc aac gag cca fall ate gac gat gtt gcg ctg gtt acc ggt gcg gct 480 Wing Asn Glu Pro His He Asp Asp Val Ala Leu Val Thr Gly Ala Ala 145 150 155 160 ect gag tcg ate gcc ggt gca gtt gcg gct cgc ctg ctg ccc tg cag ggc 528 Pro Glu Ser He Ala Gly Ala Val Ala Ala Arg Leu Leu Ser Gln Gly 165 170 175 gcg acc gtc att etc. acc gca tcg aac gtc ccc gcg cgt aag gaa 576 Wing Thr Val He Leu Thr Wing Ser Asn Val Ser Gln Wing Arg Lys Glu 180 185 190 tac gca cgc aag etc tac gct gcg aac gca acc ect aac gca aag ctg 624 Tyr Ala Arg Lys Leu Tyr Wing Wing Asn Wing Thr Pro Asn Wing Lys Leu 10 195 200 205 tgg att gtt ect gcg aac atc tcc tcc tac cgc gat gtt gat gca gtc 672 Trp He Val Pro Wing Asn Met Being Ser Tyr Arg Asp Val Asp Wing Val 210 215 220 • ate gat tgg ate ggc aac gag cag cgc gtc acc gtc ggc age acc gtc 720 He Asp Trp He Gly Asn Glu Gln Arg Val Thr Val Gly Ser Thr Val 225 230 235 240 acc gtg acc aag cca gct ctg acc cca acc ctt gcg tac cca ttc gca 768 Thr Val Thr Lys Pro Wing Leu Thr Pro Thr Leu Wing Tyr Pro Phe Wing 245 250 255 gct cca tcc gta tcc ggt acc ttg gcg gat gca ggc cca cag gct gaa 816 Wing Pro Ser Val Ser Gly Thr Leu Wing Asp Wing Gly Pro Gln Wing Glu 15 260 265 270 aac cag gca cgc ctg etc etc tgg tcc gtg gag cgc acc ate gca gga 864 Asn Gln Wing Arg Leu Leu Leu Trp Ser Val Glu Arg Thr He Wing Gly 275 280 285 ctt gca gat ctt gca tcc cgc ggt gtc gat gga cgc gtc falls gtt gta 912 leu wing asp leu wing being arg gly val asp gly arg val his val val 290 295 300 etc cca ggt tcc ccg aac cgc gga atg ttc ggt ggc gac g gc gc tac 960 Leu Pro Gly Pro Pro Asn Arg Gly Met Phe Gly Gly Asp Gly Ala Tyr • 305 310 315 320 ggc gaa gtc aag gct gct tcc gac gcc ate ctt gcc aag tgg ggc tcc 1008 Gly Glu Val Lys Ala Ala Phe Asp Ala He Leu Ala Lys Trp Gly Ser 20 325 330 335 gag acc ggc tgg cca cag ttt gtc tcc etc gca cag gca cgc ate ggc 1056 Glu Thr Gly Trp Pro Gln Phe Val Ser Leu Ala Gln Ala Arg He Gly 340 345 350 tgg gtc gca ggc acc ggc etc atg ggt cgc aac gac gtg etc ate ect 1104 Trp Val Wing Gly Thr Gly Leu Met Gly Arg Asn Asp Val Leu He Pro 355 360 365 gcc gct gaa aag ctg ggc ate fall gtc tac acc ect gaa gag ate tet 1152 Ala Ala Glu Lys Leu Gly He His Val Tyr Thr Pro Glu Glu He Ser 370 375 380 tcc gaa ctg ctg ggt ctt gca tcc gca gaa tcc cgc gaa aag gct ctg 1200 Ser Glu Leu Leu Gly Leu Ala Ser Ala Glu Ser Arg Glu Lys Ala Leu 25 385 390 395 400 gaa gca ccg ate gat tac gac ctg acc ggt gga ctt tcc ggt ggc gta 1248 Glu Ala Pro He Asp Tyr Asp Leu Thr Gly Gly Leu Ser Gly Val 405 410 415 tcc ate gca gca gt gca gca gca gca tcc etc gag tcc gac gca gta gag acc 12 * 96 Ser He Ala Ala Ala Ala Ala Ser Leu Glu Ser Asp Ala Val Glu Thr r 420 425 430 acc tet gca gca gaa gac acc ate aag gcg ctt cca tea ect aag falls 1344 Thr Ser Ala Ala Glu Asp Thr He Lys Ala Leu Pro Ser Pro Lys His 435 440 445 cca gag cag cca gtg ggc acg cca gtt gga gag gtc aag acc gat etc 1392 Pro Glu Gln Pro Val Gly Thr Pro Val Gly Glu Val Lys Thr Asp Leu 450 455 460 gaa gac atg gtt gtc atg gtt ggc gtt ggc gaa gtc tcc tea tgg ggc 1440 Glu Asp Met Val Val Met Val Gly Val Gly Glu Val Ser Ser Trp Gly 465 470 475 480 tcc gga cgt acc cgc ttc gaa gct gag tac ggc ate cag cgc gac ggc 1488 Ser Gly Arg Thr Arg Phe Glu Wing Glu Tyr Gly He Gln Arg Asp Gly 485 490 495 tcc gtt gac etc acc gca gca ggc gtc ctt gag ctt gca tgg atg atg 1536 Ser Val Asp Leu Thr Wing Wing Gly Val Leu Glu Leu Wing Trp Met Met 500 505 510 ggt ctg ate tcc tgg age gaa gat cca aag cca gcc tgg tac gac gct 1584 Gly Leu He Ser Trp Ser Glu Asp Pro Lys Pro Wing Trp Tyr Asp Ala 515 520 525 gac ggc acc gaa gtg ect gaa gaa gag ate tac gag cgc ttc cgc gac 1632 Asp Gly Thr Glu Val Pro Glu Glu Glu He Tyr Glu Arg Phe Arg Asp 530 535 540 gaa gtc ate gca cga tgc ggt gtt cgt gag ctt gtc gac gac gca ttc 1680 Glu Val He Ala Arg Cys Gly Val Arg Glu Leu Val Asp Asp Wing Phe 545 550 555 560 etc gtc gac ggc ggc tcc etc gac gca gct gaa gtc ttc etc gac cgc 1728 Leu Val Asp Gly Gly Ser Leu Asp Ala Wing Glu Val Phe Leu Asp Arg 565 570 575 gac ate tcc ttc tcc gta acc tet gct gaa gaa gca cag gcc tac gtc 1776 Asp He Ser Phe Ser Val Thr Ser Ala Glu Glu Ala Gln Ala Tyr Val 580 585 590 gat gca gat gct tcc gtg acc gtt gaa gaa gca gac ggc gaa tgg ate 1824 Asp Wing Asp Wing Ser Val Thr Val Glu Glu Wing Asp Gly Glu Trp He 595 600 605 gtg acc aag aag ggc tcc acc tcc ttc gtg cca cgc aag gca acc 1872 Val Thr Lys Lys Lys Gly Ser Thr Ser Phe Val Pro Arg Lys Wing Thr 610 615 620 ctg acc cgc tcc gta gca ggc cag ctg cca acc gac tcc gac ect gcc 1920 Leu Thr Arg Ser Val Wing Gly Gln Leu Pro Thr Asp Phe Asp Pro Wing 625 630 635 640 aag tgg ggt ate cca gcc tcc atg ate gat gca etc gac aac ate gca 1968 Lys Trp Gly He Pro Ala Ser Met He Asp Ala Leu Asp Asn He Wing 645 650 655 gcg tgg aac ctg gtc act gca gtc gac gcc ttc ctg tcc tcc ggc ttc 2016 Wing Trp Asn Leu Val Thr Wing Val Asp Wing Phe Leu Ser Ser Gly Phe 660 665 670 age cca gca gaa etc ctg cag tcc ate drops cca gct gac gtg tcc tcc 2064 Ser Pro Wing Glu Leu Leu Gln Ser He His Pro Wing Asp Val Ser Ser 675 680 685 acc ggt ggc atg ggc atg ggc atg cag tcc cta cgc aag ctg ttc 2112 Thr Gln Gly Thr Gly He Gly Gly Met Gln Ser Leu Arg Lys Leu Phe 690 695 700 falls gtg gct gca gtc gtc gtg ctg gca acc age ggc ate ttc gag cag 3072 His Val Ala Ala Val Val Val Leu Ala Thr Ser Gly He Phe Glu Gln, 1010 1015 gc atc cgc aac gca gcc gcc etc gac gtc gaa gca tgg cgc gca cgc gca 3120 wing met arg asn wing gly leu asp val glu wing trp arg wing arg wing? 1025 1030 1035 1040 acc ggc cgc cgc acc ggt gca aac cgc cta gaa gct ggc atg gtt 3168 Thr Gln Arg Leu Arg Thr Gly Wing Asn Arg Leu Glu Wing Gly Met Val 1045 1050 ggc cg gc cca gt cca ttg gag cag gtc gac gga cgc cgc ctg cca cg gag 3216 Gly Arg Wing Pro Leu Phe Glu Gln Val Asp Gly Arg Arg Leu Pro Glu 1060 1065 1070 cat ggc gct falls ca gca gag ate aac ttg ctt ate gac gct gac gct 3264 His Gly Ala His Gln Ala Glu He Asn Leu Leu He Asp Wing Asp Wing 1075 1080 1085 cgc etc ggt gct gcg gcc ate gcc tac ggc taaacgttag atagetaaga 3314 Arg Leu Gly Wing Asp Gly He Tyr Gln Gly 1090 1095 aag 3317 < 210 > 48 < 211 > 1098 < 212 > PRT < 213 > Corynebacterium glutamicum < 40? 0 > 48 Wing Being Gly Gly Gly Val Val Asp Being Wing Wing Leu Asp Wing Tyr Wing 1 5 10 15 Being Thr Val Thr Gly Glu Glu Gly Val Leu Wing Asn Val Wing Arg Gly 20 25 30 He Leu Ser Gln Leu Gly Leu Asp Thr Lys Asp Glu Val Glu Gly Wing 35 40 45 Glu He Asp Thr Glu Leu Tyr Asp Wing Val Glu Wing Glu Leu Gly Thr 50 55 60 Gly Trp Leu Lys Leu Val Thr Pro Val Phe Ser Wing Asp Arg Wing He 65 70 75 80 Leu Phe Asp Asp Arg Trp Wing Be Wing Arg Glu Asp Leu Wing Arg Leu 85 90 95 Wing Asn Gly Glu Asp He Wing Val Glu Arg Phe Wing Gly Thr Gly Glu 100 105 110 Thr Val Val Lys Gln Wing Wing Trp Trp Wing Glu His Val Glu Asp Thr 115 120 125 Wing Leu Wing Wing Thr Leu Lys Gln Val Ser Glu Wing Wing Ala Lys Pro 130 135 140 Wing Asn Glu Pro His He Asp Asp Val Wing Leu Val Thr Gly Ala Wing 145 150 155 160 Pro Glu Ser He Wing Gly Wing Val Ala Wing Arg Leu Leu Ser Gln Gly 165 170 175 Wing Thr Val He Leu Thr Wing Ser Asn Val Ser Gln Wing Arg Lys Glu 180 185 190 Tyr Wing Arg Lys Leu Tyr Wing Wing Asn Wing Thr Pro Asn Wing Lys Lions 195 200 205 Trp He Val Pro Wing Asn Met Being Ser Tyr Arg Asp Val Asp Wing Val 210 215 220 He Asp Trp He Gly Asn Glu Gln Arg Val Thr Val Gly Ser Thr Val 225 230 235 240 Thr Val Thr Lys Pro Ala Leu Thr Pro Thr Leu Ala Tyr Pro Phe Ala gtc aac cgc ttc etc ggc cag gat cgt cca tcc gac ate etc cag gag 2160 Val Asn Arg Phe Leu Gly Gln Asp Arg Pro Be Asp He Leu Gln Glu 705 710 7 71155 7 72200 acc ctg cca aac gtt gtg gct gca falls aacccc aattgg ccaagg ttcccc ttaacc ggttcc ggggtt 2208 Thr Leu Pro Asn Val Val Ala Ala His T Thhrr M Meett G Gnnn S Seerr T Tyyrr V Vaall G Gllyy 725 773300 773355 ggc tac ggc cag atg ate drops cca gtg ggccaa ggccaa ttggtt ggccaa aacccc ggccaa ggcctt 2256 Gly Tyr Gly Gln Met He His Pro Val A Allaa A Allaa C Cyyss A Allaa T Thhrr A Allaa A Allaa 740 745 775500 gtc tc gtg gaa gaa ggc gtg gac aag aattee ccggcc eettcc aaaacc aaaagg ggccaa ggaatt 2304 Val Ser Val Glu Glu Gly Val Asp Lys He Arg Leu Asn Lys Wing Asp 755 760 765 ttc gtt gtc gcc ggt ggt ate gat gac ate cag gtt gaa tcc ctg acc 2352 Phe Val Val Wing Gly Gly He Asp Asp He Gln Val Glu Ser Leu Thr 770 775 780 ggc ttc ggt gac atg aac gcc acc gca gac acc cag gca atg ctg gac 2400 Gly Phe Gly Asp Met Asn Wing Thr Wing Asp Thr Gln Wing Met Leu Asp 785 790 795 800 aag ggc ate gac cca cgc ttc ate tcc cgc gca aac gat cga cgt cgc 2448 Lys Gly He Asp Pro Arg Phe He Ser Arg Wing Asn Asp Arg Arg Arg 805 810 815 gca ggc ttc etc gaa gca gca ggt ggc ggt gtc etc ctg gca cgt 2496 Wing Gly Phe Leu Glu Wing Wing Gly Gly Gly Thr Val Leu Leu Wing Arg 820 825 830 gca tcc gtt gct gct gaa ctg gga ctg cca gtt etc gca gtt gtt gca 2544 Ala Ser Val Wing Wing Glu Leu Gly Leu Pro Val Leu Wing Val Val Wing 835 840 845 falls gca cag tcc tac gcc gat ggt gct falls acc tcc ate cca gca ccg 2592 His Wing Gln Ser Tyr Wing Asp Gly Wing His Thr Ser He Pro Wing Pro 850 855 860 gga ctt ggc gca ctg ggt gca gca cgt ggt ggc aag aag tcc gta ctt 2640 Gly Leu Gly Wing Leu Gly Wing Wing Arg Gly Gly Lys Lys Ser Val Leu 865 870 875 880 gct cgc gaa ctg aac aaa ttg ggt ctg acc cca gat gac gtt cgc gtg 2688 Wing Arg Glu Leu Asn Lys Leu Gly Leu Thr Pro Asp Asp Val Arg Val 885 890 895 gtc tcg aag falls gac acc tcc acc aac gcc aac gat cca aac gag tcc 2736 Val Ser Lys His Asp Thr Ser Thr Asn Wing Asn Asp Pro Asn Glu Ser 900 905 910 gag ctg falls to ctg ctg tgg aag acc gga cgc gaa gcc gac aac 2784 Glu Leu His Asn Leu Leu Trp Lys Thr He Gly Arg Glu Wing Asp Asn 915 920 925 ccg atg ttc gtc gtc tcc cag aag tcc ctt acc gga cae tea aag ggc 2832 Pro Met Phe Val Val Ser Gln Lys Ser Leu Thr Gly His Ser Lys Gly 930 935 940 ggt gca gca etc ttc cag ate ggt gga ctt gtc tcc ate ctg gaa acc 2880 Gly Ala Ala Leu Phe Gln He Gly Gly Leu Val Ser He Leu Glu Thr 945 950 955 960 ggc aag ctg cca cag aac gca tcc ctt gac tgc gtt gac cca gag atg 2928 Gly Lys Leu Pro Gln Asn Wing Ser Leu Asp Cys Val Asp Pro Glu Met 965 970 975 gaa gca aag ggc gag aac ttc gtc tgg ctg cgc aag cca ctg gat etc 2976 Glu Ala Lys Gly Glu Asn Phe Val Trp Leu Arg Lys Pro Leu Asp Leu 980 985 990 ggc gca ggc tcc att aag gcc gtac ctt: acc tcei ct? [ggc ttc ggc 3024 Gly Ala Gly Ser He Lys Ala Gly Val. Leu Thr Ser Leu Gly Phe Gly 995 100C) 1005 245 250 255 Wing Pro Ser Val Ser Gly Thr Leu Wing Asp Wing Gly Pro Gln Wing Glu 260 265 270 Asn Gln Wing Arg Leu Leu Leu Trp Ser Val Glu Arg Thr He Wing Gly 275 280 285 Leu Ala Asp Leu Ala Ser Arg Gly Val Asp Gly Arg Val His Val Val Glu Thr Gly Trp Pro Gln Phe Val Ser Leu Wing Gln Wing Arg He Gly 340 345 350 Trp Val Wing Gly Thr Gly Leu Met Gly Arg Asn Asp Val Leu He Pro 355 360 365 Wing Wing Glu Lys Leu Gly He His Val Tyr Thr Pro Glu Glu He Ser 370 375 380 Ser Glu Leu Leu Gly Leu Ala Ser Ala Glu Ser Arg Glu Lys Ala Leu 385 390 395 400 Glu Ala Pro He Asp Tyr Asp Leu Thr Gly Gly Leu Ser Gly Gly Val 10 405 410 415 Ser He Ala Ala Ala Ala Ala Ser Leu Glu Ser Asp Ala Val Glu Thr 420 425 430 # Thr Ser Ala Ala Glu Asp Thr He Lys Ala Leu Pro Ser Pro Lys His 435 440 445 Pro Glu Gln Pro Val Gly Thr Pro Val Gly Glu Val Lys Thr Asp Leu 450 455 460 Glu Asp Met Val Val Met Val Val Gly Val Gly Val Ser Ser Trp Gly 465 470 475 480 Be Gly Arg Thr Arg Phe Glu Wing Glu Tyr Gly He Gln Arg Asp Gly 485 490 495 Ser Val Asp Leu Thr Wing Wing Gly Val Leu Glu Leu Wing Trp Met Met 15 500 505 510 Gly Leu He Ser Trp Ser Glu Asp Pro Lys Pro Wing Trp Tyr Asp Wing 515 520 525 Asp Gly Thr Glu Val Pro Glu Glu Glu He Tyr Glu Arg Phe Arg Asp 530 535 540 Glu Val He Wing Arg Cys Gly Val Arg Glu Leu Val Asp Asp Ala Phe 545 550 555 560 Leu Val Asp Gly Gly Ser Leu Asp Wing Wing Glu Val Phe Leu Asp Arg 565 570 575 Asp He Ser Phe Ser Val Thr Ser Wing Glu Glu Wing Gln Wing Tyr Val 580 585 590 Asp Wing Asp Wing Ser Val Thr Val Glu Glu Wing Asp Gly Glu Trp He 20 595 600 605 Val Thr Lys Lys Lys Gly Ser Thr Ser Phe Val Pro Arg Lys Wing Thr 610 615 620 Leu Thr Arg Ser Val Wing Gly Gln Leu Pro Thr Asp Phe Asp Pro Wing 625 630 635 640 Lys Trp Gly He Pro Wing Wing Met He Asp Wing Leu Asp Asn Wing Wing 645 650 655 Wing Trp Asn Leu Val Thr Wing Val Asp Wing Phe Leu Ser Ser Gly Phe 660 665 670 Ser Pro Wing Glu Leu Leu Gln Ser He His Pro Wing Asp Val Ser Ser 675 680 685 Thr Gln Gly Thr Gly He Gly Gly Met Gln Ser Leu Arg Lys Leu Phe 25 690 695 700 Val Asn Arg Phe Leu Gly Gln Asp Arg Pro Ser Asp He Leu Gln Glu 705 710 715 720 Thr Leu Pro Asn Val Val Ala Wing His Thr Met Gln Ser Tyr Val Gly 725 730 735 Gly Tyr Gly Gln Met He His Pro Val Wing Wing Cys Wing Thr Wing Wing 740 745 750 Val Ser Val Glu Glu Val Asp Lys He Arg Leu Asn Lys Wing Asp Ser Leu Thr Gly Phe Gly Asp Met Asn Wing Thr Wing Asp Thr Gln Wing Met Leu Asp 785 790 795 800 Lys Gly He Asp Pro Arg Phe He Ser Arg Ala Asn Asp Arg Arg Arg 805 810 815 Ala Gly Phe Leu Glu Ala Ala Gly Gly Gly Thr Val Leu Leu Ala Arg 820 825 830 Wing Ser Val Ala Ala Glu Leu Gly Leu Pro Val Leu Ala Val Val Ala 835 840 845 His Wing Gln Ser Tyr Wing Asp Gly Wing His Thr Ser He Pro Wing Pro 850 855 860 10 Gly Leu Gly Wing Leu Gly Wing Wing Arg Gly Gly Lys Lys Ser Val Leu 865 870 875 880 Wing Arg Glu Leu Asn Lys Leu Gly Leu Thr Pro Asp Asp Val Arg Val 885 890 895 # Val Ser Lys His Asp Thr Ser Thr Asn Wing Asn Asp Pro Asn Glu Ser 900 905 910 Glu Leu His Asn Leu Leu Trp Lys Thr He Gly Arg Glu Wing Asp Asn 915 920 925 Pro Met Phe Val Val Ser Gln Lys Ser Leu Thr Gly His Ser Lys Gly 930 935 940 Gly Wing Ala Leu Phe Gln He Gly Gly Leu Val Ser He Leu Glu Thr 945 950 955 960 15 Gly Lys Leu Pro Gln Asn Wing Ser Leu Asp Cys Val Asp Pro Glu Met 965 970 975 Glu Wing Lys Gly Glu Asn Phe Val Trp Leu Arg Lys Pro Leu Asp Leu 980 985 990 Gly Wing Gly Ser He Lys Wing Gly Val Leu Thr Ser Leu Gly Phe Gly 995 1000 1005 His Val Wing Wing Val Val Val Leu Wing Thr Ser Gly He Phe Glu Gln 1010 1015 1020 Wing Met Arg Asn Wing Gly Leu Asp Val Glu Wing Trp Arg Wing Arg Wing 1025 1030 1035 1040 Thr Gln Arg Leu Arg Thr Gly Wing Asn Arg Leu Glu Wing Gly Met Val 1045 1050 1055 20 Gly Arg Wing Pro Leu Phe Glu Gln Val Asp Gly Arg Arg Leu Pro Glu 1060 1065 1070 His Gly Wing His Gln Wing Glu He Asn Leu Leu He Asp Wing Asp Wing 1075 1080 1085 Arg Leu Gly Wing Asp Gly He Tyr Gln Gly 1090 1095 < 210 > 49 < 211 > 6136 < 212 > DNA < 213 > Corynebacterium glutamicum 25 < 220 > il i r líiiMittüWri M? tn? < 221 > CDS < 222 > (101) .. (6136) < 223 > RXN03111 < 400 > 49 cgtgaccgaa • ttgagcagga aiettcggggc caigccgactg att¡aaceget • ttggiccagga 60 gccttttgcc ttcgcttticg ccggccaagg at, atgaictgg ttg aag acc ctt cgt 115 Leu Lys Thr Leu Arg 1 5 gcc gcg gtt gc gca ggt gca ggc acc aat gtt agt gac ate gtc gag 163 Ala Ala Val Ala Ala Gly Ala Gly Thr Asn Val Ser Asp He Val Glu October 15 20 gca cgc aat gcg ctg ctt gca cta gtt gca gat gat etc att ggc acc 211 Arg Ala Asn Ala Leu Leu Ala Leu Val Ala Asp Asp Leu He Gly Thr 25 30 35 ctt cca ttt ggt ttc gat cca gtg gct tgg gct aac aac tcc gaa gat 259 Leu Pro Phe Gly Phe Asp Pro Val Wing Trp Wing Asn Asn Ser Glu Asp 40 45 50 cca gct ttc gat act gca caa tet gca gtg age gtg ccg ggt ate ttt 307 355 gtg gat cag gct gtg tcc age att ggt cat tcc cag ggc gta ttg ggc 403 Val Asp Gln Wing Val Ser Ser He Gly His Ser Gln Gly Val Leu Gly 90 95 100 gtg falls ctg etc aat gat gcg act cgt gct gat gaa etc gtt gcc att 451 Val His Leu Leu Asn Asp Ala Thr Arg Ala Asp Glu Leu Val Ala He 105 110 115 gcg cag ttg ate ggt gca gcg ate acc cgc acc gca cgc atg acg ggc 499 Ala Gln Leu He Gly Ala Ala He Thr Arg Thr Ala Arg Met Thr Gly 15120125130 ctg ate gcg cag ggc gac aac atg ccg atg ctg tcg ate gcc gga att 547 Leu He Ala Gln Gly Asp Asn Met Pro Met Leu Ser He Ala Gly He 135 140 145 aka cgc gaa cag ctt cag ca gct ate gac gcg gcc tgc gcc gaa gtc 595 643 tat gtt ttg gtt ggc cgc cca gac gac aac gct cgc gtt gtt aag gtc 691 Tyr Val Leu Val Gly Arg Pro Asp Asp Asn Ala Arg Val Val Lys Val 20185190195 att gag gca atg gct gcc aag gat aag aag gcc att gaa gat aag ctg 739 He Glu Wing Met Wing Wing Lys Asp Lys Lys Wing He Glu Asp Lys Leu 200 205 210 cgc ggc gcc tcc tcc age ccc cgt att act ccg ctg aag gtg cag 787 Arg Gly Gly Be Wing Phe Ser Pro Arg He Thr Pro Leu Lys Val Gln 215 220 225 gct gct ttc cat drops cca gct atg aac atg gct gtg gag cag acc gtg 835 Wing Wing Phe His His Pro Wing Met Asn Met Wing Val Glu Gln Thr Val 230 235 240 245 gcg tgg gca acc act gct ggt ttg gat gtg gaa etc acc cgc gag ate 883 Wing Trp Wing Thr Thr Wing Gly Leu Asp Val Glu Leu Thr Arg Glu He 25 250 255 260 í ^ ^^ ^^ jm gcc gct gat gtt gtt ttg aac tgg gat gca gtc ect gta gtc aac cgc 931 Ala Val Leu Ala Asp Pro Asn Val Trp Asp Val Val Ala Arg Asn Val 265 270 275 gcg gaa tat i gag gct ggc gct cgc tgg ttc etc gac gtt gga cca gat 979 Glu Wing Tyr Glu Wing Gly Wing Arg Trp Phe Leu Asp Val Gly Pro Asp '' 280 285 290 ggt ggc ate gtt aag ctg act gcc aac ate ctt gag ggc cgc ggc gcg 1027 Gly Gly He Val Lys Leu Thr Wing Asn He Leu Glu Gly Arg Gly Wing 295 300 305 • gat tcc ttc tat gtt ggt gac gcc gca ggc cag gcc aag ata ttt gat 1075 Asp Ser Phe Tyr Val Gly Asp Wing Wing Gly Gln Wing Ala He Phe Asp 310 315 320 325 gct ggc atg gca ect gaa ctt cca gtg gat tac cag gag ttc gca cca 1123 Ala Gly Met Ala Pro Glu Leu Pro Val Asp Tyr Gln Glu Phe Ala Pro 330 335 340 cgc gtt gag falls gtt gat gga acc cca cgc ctg gtt acc aag ttc act 1171 Arg Val Glu His Val Asp Gly Thr Pro Arg Leu Val Thr Lys Phe Thr 345 350 355 gag ctg acc ggc cgc acc cca atg atg ctg gct ggc atg acc cca acc 1219 Glu Leu Thr Gly Arg Thr Pro Met Met Leu Wing Gly Met Thr Pro Thr 10 360 365 370 acc gtt gac ect gcc att gtt gca gcc gct gca aac ggt gga falls tgg 1267 Thr Val Asp Pro Wing He Val Wing Wing Wing Wing Asn Gly Gly His Trp 375 380 385 # gct gag etc gct ggt ggc gga cag gtt acc cca gag ctg ctg gaa acc 1315 Wing Glu Leu Wing Gly Gly Gly Gln Val Thr Pro Glu Leu Glu Thlu 390 395 400 405 falls gca cag cag etc acc gac atg ctt gag cca ggt ate aac gcc cag 1363 His He Wing Gln Leu Thr Asp Met Leu Glu Pro Gly He Asn Wing Gln 410 415 420 ttc aac tcc atg ttc ttg gat cca tac tg agg atg cag att ggt 1411 Phe Asn Ser Met Phe Leu Asp Pro Tyr Leu Trp Lys Met Gln He Gly 15 425 430 435 ggc aag cgc ctt gtt ect aag gcc cgc gct aat ggt gca tcc ate gac 1459 Gly Lys Arg Leu Val Pro Lys Ala Arg Ala Asn Gly Ala Ser He Asp 440 445 450 ggc ate gtc ate acc gcc ggc att ect gaa aag gat gaa gct gtt gca 1507 Gly He Val He Thr Wing Gly He Pro Glu Lys Asp Glu Wing Val Wing 455 460 465 ttg gtc aag gaa ctg atg cgt gat ggt ttc ect tgg ate gca ttc aag 1555 Leu Val Lys Glu Leu Met Arg Asp Gly Phe Pro Trp He Wing Phe Lys 470 475 480 485 cca ggt gcc ate aag cag gtt aac tet gtg ttg gct ate gct aag gaa 1603 Pro Gly Ala He Lys Gln Val Asn Ser Val Leu Ala He Ala Lys Glu 20 490 495 500 gtt cca gaa etc ccc ate ate att cag att gag ggt ggc gtt gca ggt 1651 Val Pro Glu Leu Pro He He He Gln He Glu Gly Gly Val Ala Gly 505 510 515 gga falls falls tet tgg gaa gac etc gat gag ctg ctg ate gcc acc tac 1699 Gly His Ser Trp Glu Asp Leu Asp Glu Leu Leu He Wing Thr Tyr 520 525 530 ggc aag gtc cgc gca ctg gat aac gtg gtg ctg tgt gtc ggc ggt ggc 1747 Gly Lys Val Arg Ala Leu Asp Asn Val Val Leu Cys Val Gly Gly Gly 535 540 545 att ggc tea ect gag cgc gct gct gat tac gtc acc ggg tcc tgg tcc 1795 He Gly Ser Pro Glu Arg Ala Wing Asp Tyr Val Thr Gly Ser Trp Ser 25 550 555 560 565 A ^ k act tcc tac ggc ctg cca gct atg ect gtt gat ggc ate ttg gtg ggt 1843 Thr Ser Tyr Gly Leu Pro Wing Met Pro Val Asp Gly He Leu Val Gly 570 575 580 acc gct gcg atg gca acc aag gaa gca acc acc tcc cag gcc gtc aag 18í91 Thr Wing Wing Met Wing Thr Lys Glu Wing Thr Thr Ser Gln Wing Val Lys 585 590 595 gaa ctt ctt gtt tcc acc cag ggc tet gat gaa tgg gtt ect gct ggt 1939 Glu Leu Leu Val Ser Thr Gln Gly Ser Asp Glu Trp Val Pro Wing Gly 600 • 605 610 ggc gca aag aac gga atg gca tet ggc cgt tcc cag ctt ggc gca gac 1987 Gly Wing Lys Asn Gly Met Wing Ser Gly Arg Ser Gln Leu Gly Wing Asp 615 620 625 tie falls gag ate gac aac tcc ttt gct aag gct gga cgc ctt ctt gat 2035 He His Glu He Asp Asn Ser Phe Ala Lys Ala Gly Arg Leu Leu Asp 630 635 640 645 gag gtt gca ggc gat gag acg gctg gg gg gg cgc ggg gat gag ate 2083 Glu Val Wing Gly Asp Glu Thr Wing Val Gln Wing Arg Arg Asp Glu He 650 655 660 att gaa gcg att ggc aag acc gcc aag gtg tac ttc ggt gac ate gga 2131 He Glu Wing He Gly Lys Thr Wing Lys Val Tyr Phe Gly Asp He Gly 10 665 670 675 tcc atg act tac gag cag tgg etc aac cgc tac etc gag ctg tet ggc 2179 Leu Ser Gly cgt ttt gcc 2227 Arg Phe Wing cag atg ctg gag cgt gcc gag gcg cgt ttg ate gag cag gat cat ggc 2275 Gln Met Leu Glu Arg Wing Glu Wing Arg Leu He Glu Gln Asp His Gly 710 715 720 725 cat ttt gag cca age ctg acg gtg gag gat ggc gtc gac aag ctt gtt 2323 Gln Phe Glu Pro Ser Leu Thr Val Glu Asp Gly Val Asp Lys Leu Val 15 730 735 740 gct gct tac ccg cat gcc gca acc gac ctg etc acc ccg gct gat gtc 2371 Ala Ala Tyr Pro His Ala Ala Thr Asp Leu Leu Thr Pro Ala Asp Val 745 750 755 gcc tgg ttc ttg ggc ctg tgc cgc acg ccg ggc aag ect gtg aac ttt 2419 Wing Trp Phe Leu Gly Leu Cys Arg Thr Pro Gly Lys Pro Val Asn Phe 760 765 770 gtg ccc gtc att gat aag gac gtg cgt cgc tgg tgg cgc tcg gac tcc 2467 Val Pro Val He Asp Lys Asp Val Arg Arg Trp Trp Arg Ser Asp Ser 775 780 785 ctg tgg cag tcc falls gat gat cgc tac acc gct gat cag gtg gct att 2515 Leu Trp Gln Ser His A sp Asp Arg Tyr Thr Wing Asp Gln Val Wing He 20 790 795 800 805 ate ect ggt gtc gtc gcc gtt gct ggc ate acc aag gcc aac gaa ect 2563 He Pro Gly Val Val Ala Wing Ala Gly He Thr Lys Ala Asn Glu Pro 810 815 820 gtc gct gac ctg ctt gat cgc ttt gtc gac gcc acc ate gag cgc ate 2611 Val Wing Asp Leu Leu Asp Arg Phe Val Asp Wing Thr He Glu Arg He 825 830 835 gat gag falls gat tcc cgc tcc cgc gac ate atg ggc aaa gtg ctt tcc 2659 Asp Glu His Asp Ser Arg Ser Arg Asp He Met Gly Lys Val Leu Ser 840 845 850 tea ect ggc here ttc tgg ggc cgc aac ate cca tcg gtg ate cae 2707 Ser Pro Gly Thr Phe Trp Wing Gly Arg Asn He Pro Ser Ser Val He His 25 855 860 865 - • ¿J - ** *! * Age ctt ggg cat gct gac aag tgg tcc cgc tcc gaa ttc gaa gca ttc 275? Ser Leu Gly His Wing Asp Lys Trp Ser Arg Ser Glu Phe Glu Wing Phe 870 875 880 885 cat age cca acc ggc gcc aac ttg gtg tac gaa gac gcc gag drops gcg 28p3 His Ser Pro Thr Gly Wing Asn Leu Val Tyr Glu Asp Wing Glu His Wing 890 895 900 atg ctg act gtg ect ttg gcg ggt tcc acc gca ttc ggc acc accctct 2851 Met Leu Thr Val Pro Leu Wing Gly Ser Thr Wing Phe Gly Thr Thr Wing 905 910 915 * gag ctg aaa ate cgt ttc acc age ccc ate gac gct ctg cca age gct 2899 Glu Leu Lys He Arg Phe Thr Ser Pro He Asp Ala Leu Pro Ser Wing 920 925 930 gtc cca ctg gtc acc cag gaa gac gct gaa gcc gcg atg ggt gaa ctg 2947 Val Pro Leu Val Thr Gln Glu Asp Wing Glu Wing Wing Met Gly Glu Leu 935 940 945 acc cgc ate gca gct ggc ggc acc ctg gca act gtg aac aat ggc acc 2995 Thr Arg Wing Wing Wing Gly Gly Thr Leu Wing Thr Val Asn Asn Gly Thr 950 955 960 965 gct acc tgg gaa acc tcc gc gc gc gc gc gc gc gcc gac taac aac 3043 Thr wing Trp Glu Thr Ser Val Asp Wing Gly Val He Wing Asp Tyr Asn 980 falls acc 3091 His Thr gca ect gac gtg ct g gtt ggc cgc ggccaa ttgggg ccccaa ggccaa gtt tcc gct gcc 3139 Wing Pro Asp Val Leu Val Gly Arg AAllaa TTrrpp P Prroo A Allaa Val Phe Ala Wing 1000 1005 1010 gta aag tcc gca gtc ate cca ggc acc gat tcc gca tcc gtt gtg gaa 3187 Val Lys Ser Ala Val He Pro Gly Thr Asp Ser Ala Ser Val Val Glu 1015 1020 1 100225 ggc atg ctg tcc ctg gtt falls ctg gag falls falls aattt gtg etc aag tcc 3235 Gly Met Leu Ser Leu Val His Leu Glu His His H 11e Val Leu Lys Ser 15 1030 1035 1 100440C) 1045 gat gtc cca acc gac ggc gcg ctg aag gtt tctcccc ggccgg act gcc gat gag 3283 Asp Val Pro Thr Asp Gly Wing Leu Lys Val S Seerr A Allaa Thr Wing Asp Glu 1050 1055 1060 gta gtc gat gat gct cgc cgc etc ggttgg aattee ggttgg cgc gca gaa ate 3331 Val Val Asp Thr Asp Leu Gly Arg Leu VVaall H Hee V Vaall Arg Wing Glu He 1065 1070 1075 gcc gac gca gaa ggc aac ctg att gct aaccgg ttttgg ggcctt gag cgt tcc gcg 3379 Wing Asp Wing Glu Gly Asn Leu He AAllaa TThhrr L Leeuu A Allaa Glu Arg Phe Wing 1080 1085 1090 ate cgc gga cgc aag ggc aac gct gtc gca cgc acc aac acc aac gcc 3427 He Arg Gly Arg Lys Gly Asn Ala Val Ala Arg Thr Asn Thr Ser Ala 20 1095 1100 1105 ctg cca acc acc gtg gac acc cca cgc tea gct cgc gca gtg gca acc 347 Leu Pro Thr Thr Val Asp Thr Pro Arg Ser Wing Arg Ala Val Wing Thr 11 10 1115 1120 1125 gtt gtt gca ect gaa tc atg cgc cca tcc gct gct gcc tc ggt gac 3523 Val Val Wing Pro Glu Ser Met Arg Pro Phe Wing Val He Ser Gly Asp 1130 1135 1140 ccc ccc aac cca att cc gtc tet gat gtt gcg gct tcc ctg gct ggt ctg 3571 Arg Asn Pro He His Val Ser Asp Val Wing Wing Ser Leu Wing Gly Leu 1145 1150 1155 cca ggt gtg gtg ate gtg ggc atg tgg tg acc tet gcc ate ggt gaa ctg 3619 Pro Gly Val He Val His Gly Met Trp Thr Ser Wing He Gly Glu Leu 25 1160 1165 1170 ate gcc ggggtt ggccaa ggccaa tc aac gat gag cag ate cac act ccc gca gcc 3667 He Wing Wing Gllyy AAllaa AAllaa Phe Asn Asp Glu Gln He Gln Thr Pro Wing Wing 1175 1180 1185 aag gtc gtg gaa tac acc gca acc atg ctg gca cca gtt ctt cca ggt 13715 Lys Val. Val Glu Tyr Thr Wing Thr Met Leu Wing Pro Val Leu Pro Gly 1190 1195 1200 1205 gaa gaa att gag ttc age gtt gag cgc tcc gca gtg gac aac cgc cca 3763 Glu Glu He Glu Phe Ser Val Glu Arg Ser Wing Val Asp Asn Arg Pro 1210 1215 1220 gga atg gga gag gtc cgc acc gtt acc gta acc gtc aac ggc aac tta 3811 Gly Met Gly Glu Val Arg Thr Val Thr Wing Thr Val Asn Gly Asn Leu 1225 1230 1235 gtg ctt acc gcc gct action gtg gca gca gct cca tet act tc tac gca 3859 Val Leu Thr Ala Thr Ala Val Val Ala Ala Pro Ser Thr Phe Tyr Wing 1240 1245 1250 tcc cca ggc cag ggc att cag tcc cag ggc atg ggt atg gaa gca cgc 3907 Phe Pro Gly Gln Gly He Gln Ser Gln Gly Met Gly Met Glu Wing Arg 1255 1260 1265 cgt aac: tet cag gca gct cgc gct ate tgg gac cgc gcc gat gca falls 3955 His 1285 aac 4003 Asn ggc 4051 Gly gtt ttg tac etc acc cag ttc acc cag gtg ggc atg gca act ctg ggc 4099 Val Leu Tyr Leu Thr Gln Phe Thr Gln Val Gly Met Wing Thr Leu Gly 1320 1325 1330 gtt gct cag ate gct gaa atg cgt gaa gca cat gcc ttg aac cag cgt 4147 Val Ala Gln He Ala Glu Met Arg Glu Ala His Ala Leu Asn Gln Arg 15 1335 1340 1345 gca tac ttt gct gga falls tcc gtt ggt gag tac aac gcg ctt gct gca 4195 Wing Tyr Phe Wing Gly His Ser Val Gly Glu Tyr Asn Wing Ala Leu Wing 1350 1355 1360 1365 tat gct ggt gtg ctg tcc ctg gaa tcc gtt ctg gag ate gtt tac cgt 4243 Tyr Wing Gly Val Leu Ser Leu Glu Ser Val Leu Glu He Val Tyr Arg 1370 1375 1380 cgt ggc ttg acc atg falls cgc ttg gtg gat cgc gat gaa aac ggt ctg 4291 Arg Gly Leu Thr Met His Arg Leu Val Asp Arg Asp Glu Asn Gly Leu 1385 1390 1395 tcc aac tac gcg etc gca gct ctt cgc ccc aac aag atg ggt ctg acc 4339 Ser Asn Tyr Ala Leu Ala Ala Leu Arg Pro Asn Lys Met Gly Leu Thr 20 1400 1405 1410 gca gac aac gtt ttc gat tac gtt gcg tet gtt tcc gaa gct tcc ggt 4387 wing Asp Asn Val Phe Asp Tyr Val Wing Ser Val Ser Glu Wing Ser Gly 1415 1420 1425 gaa ttc c tg gag ate gtt aac tac aac ttg gct ggc ctg cag tac gca 4435 Glu Phe Leu Glu He Val Asn Tyr Asn Leu Wing Gly Leu Gln Tyr Wing 1430 1435 1440 1445 gtt gct gga acc ggt cact ggt ctt gcc gcc ctt cgt gcc gat gtt gag 4483 Val Wing Gly Thr Gln Wing Gly Leu Wing Wing Leu Arg Wing Asp Val Glu 1450 1455 1460 aac cgt gca cca ggt cag cgt gcc ttc att ttg ate ect ggc att gac 4531 Asn Arg Ala Pro Gly Gln Arg Ala Phe He Leu He Pro Gly He Asp 25 1465 1470 1475 g ^^^^^^ gjH ^^ j gtg cca ttc falls tcc tcc aag ctg cgc gac ggt gtg ggc gcg ttc cgt 4579 Val Pro Phe His Ser Ser Lys Leu Arg Asp Gly Val Gly Wing Phe Arg 1480 1485 1490 gag drops ctt gat tcc ctg ate cca gct gag ctg gat ctg gat gtg ctg 4 ^ 27 1 Glu His Leu Asp Ser Leu He Pro Wing Glu Leu Asp Leu Asp Val Leu 1495 1500 1505 gtt ggc cgc tac att cca aac ttg gtg gct cgc cca ttc gaa etc act 4675 Val Gly Arg Tyr He Pro Asn Leu Val Wing Arg Pro Phe Glu Leu Thr 1510 1515 1520 1525 gaa gag ttc gtg gca tcc atg gca gaa gtg gtg gag tcc acc tat gtc 4723 Glu Glu Phe Val Ala Wing Met Wing Glu Val Val Glu Ser Thr Tyr Val 1530 1535 1540 aat gag ate ttg gct gat ttc aag gct gcc tcc gcc gat aag cag aag 4771 Asn Glu He Leu Wing Asp Phe Lys Wing Wing Being Wing Asp Lys Gln Lys 1545 1550 1555 ctt gcc cgc acg ttg ctt att gag ctg ctt gca tgg cag ttc gca tea 4819 Leu Ala Arg Thr Leu Leu He Glu Leu Leu Wing Trp Gln Phe Wing Ser 1560 1565 1570 ect gtg cgc tgg ate gag act cag gat ctg ttg ate aag ggc ctt ca 4867 Pro Val Arg Trp He Glu Thr Gln Asp Leu Leu He Lys Gly Leu Gln 1575 1580 1585 gct gag cgt ttc gtg gag gtc ggt gtt ggc tet gct cca acg ctt gcc 4915 Wing Glu Arg Phe Val Glu Val Gly Val Gly Ser Wing Pro Thr Leu Ala 1590 1595 1600 1605 aac atg atg ggc cag acc ctg cgc ctt ect cag tac gcg gac gcc acc 4963 Asn Met Met Gly Gln Thr Leu Arg Leu Pro Gln Tyr Wing Asp Wing Thr 1610 1615 1620 att gag gtg tta aac att gag cgc gat cgc cca gtt gtg ttc gct acc 5011 He Glu Val Leu Asn He Glu Arg Asp Arg Pro Val Val Phe Ala Thr 1625 1630 1635 gat gag gtt gtg cgt gaa gtg gcg gtt gaa gag acc cca gca gct ect 5059 Asp Glu Val Val Arg Glu Val Val Wing Val Glu Glu Thr Pro Ala Wing Pro 1640 1645 1650 gca gaa acc ac gaa ac cca gca ac cca gca acc acca gcc ect gtt 5107 Wing Glu Thr Thr Glu Thr Pro Wing Thr Pro Wing Thr Pro Wing Pro Val 1655 1660 1665 gca gcc gcc ect gcc acc ggc ggc ect cgc cca gat gac ate age 5155 Ala Ala Ala Ala Pro Ala Thr Gly Gly Pro Arg Pro Asp Asp He Ser 1670 1675 168C) 1685 ttc act ect tet gat gcc act gaa atg etc. ate gct ate tgg acc aag 5203 Phe Thr Pro Ser Asp Wing Thr Glu Met Leu He Wing He Trp Thr Lys 1690 1695 1700 gtt cgc cca gat cag atg ggt gcc tct gat tcc ate gag acc ctg gtt 5251 Val Arg Pro Asp Gln Met Gly Wing Thr Asp Ser He Glu Thr Leu Val 1705 1710 1715 gag ggc gtg tcc tet cgc cgt aac cag etc ctg ctg gat ctt ggt gtg 5299 Glu Gly Val Ser Ser Arg Arg Asn Gln Leu Leu Leu Asp Leu Gly Val 1720 1725 1730 gag ttc ggc etc ggc gca att gac gga gca gcc gat gct gag etc ggt 5347 Glu Phe Gly Leu Gly Wing He Asp Gly Wing Wing Asp Wing Glu Leu Gly 1735 1740 1745 gat cta aag gtc acc gtg tcc aag atg gct aag ggc tac aag gcg ttt 5395 Asp Leu Lys Val Thr Val Ser Lys Met Wing Lys Gly Tyr Lys Wing Phe 175C 1 1755, 176C 1 1765 ggc ect gtg etc tcc gat gct gca gct gat gcc ctg cgt cgc etc act 5443 Gly Pro Val Leu Ser Asp Ala Ala Ala Asp Ala Leu Arg Arg Leu Thr 1770 1775 1780 ggt ect acc ggt aag cgc ccg gga tac ate gca gag cgc gtc acc ggc 5491 Gly Pro Thr Gly Lys Arg Pro Gly Tyr He Wing Glu Arg Val Thr Gly 1785 1790 1795 acg tgg gaa ttg ggc cag ggc tgg gct gac falls gtg gtc gct gaa gtt 5539 Thr Trp Glu Leu Gly Gln Gly Trp Ala Asp His Val Val Ala Glu Val 1800 1805 1810 gtg ate ggc gcc cgc gaa ggc gca aka ctg cgc ggc ggc gac ctg gcg 5587 Val He Gly Ala Arg Glu Gly Ala Ser Leu Arg Gly Gly Asp Leu Ala 1815 1820 1825 tea ctg tet ect gca age cca gcg tet gca tea gat ctt gat tcg ctt 5635 Ser Leu Ser Pro Ala Ser Pro Ala Ser Ala Ser Asp Leu Asp Ser Leu 1830 1835 1840 1845 ate gac gca gcc gtc cag gcc gta gcc tcc CGC CGC GGC GTT GCG gtc 5683 I Asp Ala Ala Val Gln Ala Val Ala Ser Arg Arg Gly Val Ala Val 1850 1855 1860 aka CTG ect tea GCA GGC GGC GCT gcc GGT GGC GTG GTT gat aka GCA 5731 Ser Leu Pro Ser Ala Gly Gly Ala Ala Gly Gly Val Val Asp Ser Ala 1865 1870 1875 gct ctt ggc gag ttt gca gag cag gtc acc gga falls gat ggt gtg ctt 5779 Ala Leu Gly Glu Phe Ala Glu Gln Val Thr Gly His Asp Gly Val Leu 1880 1885 1890 gct cag gca gcc cgc acc ate ttg acc cag ttg ggt ctt gat aag cca 5827 Ala Gln Ala Ala Arg Thr He Leu Thr Gln Leu Gly Leu Asp Lys Pro 1895 1900 1905 gca acc gtt tcc gtg gaa gac acc gca gag gaa gac etc tac gag ttg 5875 Wing Thr Val Ser Val Glu Asp Thr Wing Glu Glu Asp Leu Tyr Glu Leu 1910 1915 1920 1925 gtc tcc aag gaa etc ggt tet gat tgg cca cgt cag GTT GCA cca age 5923 Val Ser Lys Glu Leu Gly Ser Asp Trp Pro Arg Gln Val Ala Pro Ser 1930 1935 1940 ttc gat gaa gaa AAG GTT GTT CTG ctt gat gac CGT TGG GCT tet GCG 5971 Phe Asp Glu Glu Lys Val Val Leu Leu Asp Asp Arg Trp Ala Ser Ala 1945 1950 1955 cgt gag gat etc aka gcg ttg etc ttg gcg aac tcg cag caa ctg ata 6019 Arg Glu Asp Leu Ser Ala Leu Leu Leu Ala Asn Ser Gln Gln Leu He 1960 1965 1970 tcg atg tea cag gcg cag gcg aag ctg ttg cag falls aag ctg aat tet 6067 Ser Met Ser Gln Ala Gln Ala Lys Leu Leu Gln His Lys Leu Asn Ser 1975 1980 1985 ttg ttg atg gat ate TCG TCG GGC CGA CTA cag aag ctt ctt gga here 6115 Asp Leu Leu Leu Gln Met Ser Gly He Ser Leu Leu Arg Gly Lys Thr 1990 1995 2000 2005 CGC CGA CTA TGC GGC tgt caá 6136 Leu Arg Arg Gln Cys Cys Gly 2010 < 210 > 50 < 211 > 2012 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 50 Leu Lys Thr Leu Arg Ala Ala Ala Ala Ala Gly Ala Gly Thr Asn Val 1 5 10 15 Ser Asp He Val Glu Arg Ala Asn Ala Leu Leu Ala Leu Val Ala Asp 20 25 30 Asp Leu He Gly Thr Leu Pro Phe Giy Phe Asp Pro Val Wing Trp Wing 35 40 45 Asn Asn Ser Glu Asp Pro Wing Phe Asp Thr Wing Gln Ser Wing Val Ser 50 55 60 Val Pro Gly He Phe Val Ser Gln He Wing Thr Leu Asp Ser Leu Glu 65 70 75 80 Wing Gln Arg Leu Asp Val Asp Gln Ala Val Ser Ser He Gly His Ser 85 90 95 Gln Gly Val Leu Gly Val His Leu Leu Asn Asp Wing Thr Arg Wing Asp 100 105 110 Glu Leu Val Wing Wing Gln Leu He Gly Wing Wing He Thr Arg Thr 115 120 125 Wing Arg Met Thr Gly Leu He Wing Gln Gly Asp Asn Met Pro Met Leu 130 135 140 Ser He Wing Gly He Ser Arg Glu Gln Leu Gln Gln Wing He Asp Wing 145 150 155 160 Wing Cys Wing Glu Val Pro Wing Glu He Arg Pro Val He Gly Leu Arg 165 170 175 Asn Ser Arg Asp Ser Tyr Val Leu Val Gly Arg Pro Asp Asp Asn Wing 180 185 190 Arg Val Val Lys Val He Glu Wing Ala Wing Wing Lys Asp Lys Lys Wing 195 200 205 He Glu Asp Lys Leu Arg Gly Gly Be Ala Phe Ser Pro Arg He Thr 210 215 220 Pro Leu Lys Val Gln Ala Ala Phe His His Pro Ala Ala Asn Met Ala 225 230 235 240 Val Glu Gln Thr Val Ala Trp Ala Thr Thr Ala Gly Leu Asp Val Glu 245 250 255 Leu Thr Arg Glu He Ala Wing Asp Val Leu Val Asn Pro Val Asp Trp 260 265 270 Val Ala Arg Val Asn Glu Ala Tyr Glu Ala Gly Ala Arg Trp Phe Leu 275 280 285 Asp Val Gly Pro Asp Gly Gly He Val Lys Leu Thr Wing Asn He Leu 290 295 300 Glu Gly Arg Gly Wing Asp Ser Phe Tyr Val Gly Asp Wing Wing Gly Gln 305 310 315 320 Wing Lys He Phe Asp Wing Gly Met Wing Pro Glu Leu Pro Val Asp Tyr 325 330 335 Gln Glu Phe Wing Pro Arg Val Glu His Val Asp Gly Thr Pro Arg Leu 340 345 350 Val Thr Lys Phe Thr Glu Leu Thr Gly Arg Thr Pro Met Met Leu Wing 355 360 365 Gly Met Thr Pro Thr Thr Val Asp Pro Wing He Val Wing Ala Wing Wing 370 375 380 Asn Gly Gly His Trp Wing Glu Leu Wing Gly Gly Gly Gln Val Thr Pro 385 390 395 400 Glu Leu Leu Glu Thr His He Wing Gln Leu Thr Asp Met Leu Glu Pro 405 410 415 Gly He Asn Wing Gln Phe Asn Ser Met Phe Leu Asp Pro Tyr Leu Trp 420 425 430 Lys Met Gln He Gly Gly Lys Arg Leu Val Pro Lys Wing Arg Wing Asn 435 440 445 Gly Wing Be He Asp Gly He Val He Thr Wing Gly He Pro Glu Lys 450 455 460 Asp Glu Ala Wing Ala Leu Val Lys Glu Leu Met Arg Asp Gly Phe Pro 465 470 475 480 Trp He Wing Phe Lys Pro Gly Wing He Lys Gln Val Asn Ser Val Leu 485 490 495 • ^ "^ Wing Wing Wing Lys Glu Val Pro Glu Leu Pro He He He Gln He Glu 500 505 510 Gly Val Wing Wing Gly Gly His His Ser Trp Glu Asp Leu Asp Glu Leu 515 520 525 Leu He Wing Thr Tyr Gly Lys Val Arg Ala Leu Asp Asn Val Val Leu 530 535 540 Cys Val Gly Gly Gly He Gly Ser Pro Glu Arg Ala Wing Asp Tyr Val 545 550 555 560 5 Thr Gly Ser Trp Ser Thr Ser Tyr Gly Leu Pro Wing Met Pro Val Asp 565 570 575 Gly He Leu Val Gly Thr Wing Wing Met Wing Thr Lys Glu Wing Thr Thr 580 585 590 Ser Gln Wing Val Lys Glu Leu Val Val Ser Thr Gln Gly Ser Asp Glu 595 600 605 Trp Val Pro Wing Gly Gly Wing Lys Asn Gly Met Wing Being Gly Arg Ser 610 615 620 Gln Leu Gly Wing Asp He His Glu He Asp Asn Being Phe Wing Lys Wing 625 630 635 640 Gly Arg Leu Leu Asp Glu Val Wing Gly Asp Glu Thr Wing Val Gln Wing 645 650 655 10 Ar9 Arg Asp Glu He He Glu Wing He Gly Lys Thr Wing Lys Val Tyr 660 665 670 Phe Gly Asp He Gly Ser Met Thr Tyr Glu Gln Trp Leu Asn Arg Tyr 675 680 685 Leu Glu Leu Ser Gly Pro Val Asp Gly Gln Trp He Asp Wing Ser Trp 690 695 700 Wing Wing Arg Phe Wing Gln Met Leu Glu Arg Wing Glu Wing Arg Leu He 705 710 715 720 Glu Gln Asp His Gly Gln Phe Glu Pro Ser Leu Thr Val Glu Asp Gly 725 730 735 Val Asp Lys Leu Val Wing Wing Tyr Pro His Wing Wing Thr Asp Leu Leu 740 745 750 15 Thr Pro Wing Asp Val Wing Trp Phe Leu Gly Leu Cys Arg Thr Pro Gly 755 760 765 Lys Pro Val Asn Phe Val Pro Val He Asp Lys Asp Val Arg Arg Trp 770 775 780 Trp Arg Ser Asp Ser Leu Trp Gln Ser His Asp Asp Arg Tyr Thr Ala 785 790 795 800 Asp Gln Val Wing He He Pro Gly Val Val Wing Val Wing Gly He Thr 805 810 815 Lys Wing Asn Glu Pro Val Wing Asp Leu Leu Asp Arg Phe Val Asp Wing 820 825 830 Thr He Glu Arg He Asp Glu His Asp Ser Arg Ser Arg Asp He Met 835 840 845 20 G1 ^ Lys Val Leu Ser Ser Pro Gly Thr Phe Trp Wing Gly Arg Asn He 850 855 860 Pro Ser Val He His Ser Leu Gly His Wing Asp Lys Trp Ser Arg Ser 865 870 875 880 Glu Phe Glu Wing Phe His Ser Pro Thr Gly Wing Asn Leu Val Tyr Glu 885 890 895 Asp Wing Glu His Wing Met Leu Thr Val Pro Leu Wing Gly Ser Thr Wing 900 905 910 Phe Gly Thr Thr Wing Glu Leu Lys He Arg Phe Thr Ser Pro He Asp 915 920 925 Wing Leu Pro Be Wing Val Pro Leu Val Thr Gln Glu Asp Wing Glu Wing 930 935 940 25 Wing Met Gly Glu Leu Thr Arg He Wing Wing Gly Gly Thr Leu Wing Thr • * «^ * '* m * ut - - - 945 950 955 960 Val Asn Asn Gly Thr Wing Thr Trp Glu Thr Ser Val Asp Wing Gly Val 965 970 975 He Wing Asp Tyr Asn Asn Val Thr Wing Gly Tyr Leu Pro Wing Ser Val 980 985 990 Val Pro Wing His Thr Wing Pro Asp Val Leu Val Gly Arg Ala Trp Pro 995 1000 1005 Wing Val Phe Wing Wing Val Lys Ser Wing Val He Pro Gly Thr Asp Ser 1010 1015 1020 Wing Ser Val Val Glu Gly Met Leu Ser Leu Val His Leu Glu His His 1025 1030 1035 1040 He Val Leu Lys Ser Asp Val Pro Thr Asp Gly Ala Leu Lys Val Ser 1045 1050 1055 Wing Thr Wing Asp Glu Val Val Asp Thr Asp Leu Gly Arg Leu Val He 1060 1065 1070 Val Arg Ala Glu He Ala Asp Ala Glu Gly Asn Leu He Ala Thr Leu 1075 1080 1085 Wing Glu Arg Phe Wing He Arg Gly Arg Lys Gly Asn Wing Val Wing Arg 1090 1095 1100 Thr Asn Thr Ser Wing Leu Pro Thr Thr Val Asp Thr Pro Arg Ser Wing 1105 1110 1115 1120 Arg Ala Val Ala Thr Val Val Ala Pro Glu Ser Met Arg Pro Phe Ala 1125 1130 1135 Val He Ser Gly Asp Arg Asn Pro He His Val Ser Asp Val Ala Ala 1140 1145 1150 Ser Leu Wing Gly Leu Pro Gly Val He Val His Gly Met Trp Thr Ser 1155 1160 1165 Wing He Gly Glu Leu He Wing Gly Wing Wing Phe Asn Asp Glu Gln He 1170 1175 1180 Gln Thr Pro Wing Wing Lys Val Val Glu Tyr Thr Wing Thr Met Leu Wing 1185 1190 1195 1200 Pro Val Leu Pro Gly Glu Glu He Glu Phe Ser Val Glu Arg Ser Ala 1205 1210 1215 Val Asp Asn Arg Pro Gly Met Gly Glu Val Arg Thr Val Thr Ala Thr 1220 1225 1230 Val Asn Gly Asn Leu Val Leu Thr Ala Thr Ala Val Val Ala Ala Pro 1235 1240 1245 Ser Thr Phe Tyr Wing Phe Pro Gly Gln Gly He Gln Ser Gln Gly Met 1250 1255 1260 Gly Met Glu Wing Arg Arg Asn Ser Gln Wing Wing Arg Wing He Trp Asp 1265 1270 1275 1280 Arg Ala Asp Ala His Thr Arg Asn Lys Leu Gly Phe Ser He Val Glu 1285 1290 1295 He Val Glu Asn Asn Pro Arg Glu Val Thr Val Ala Gly Glu Lys Phe 1300 1305 1310 Phe His Pro Asp Gly Val Leu Tyr Leu Thr Gln Phe Thr Gln Val Gly 1315 1320 1325 Met Wing Thr Leu Gly Val Wing Gln He Wing Glu Met Arg Glu Wing His 1330 1335 1340 Ala Leu Asn Gln Arg Ala Tyr Phe Ala Gly His Ser Val Gly Glu Tyr 1345 1350 1355 1360 Asn Ala Leu Ala Ala Tyr Ala Gly Val Leu Ser Leu Glu Ser Val Leu 1365 1370 1375 Glu He Val Tyr Arg Arg Gly Leu Thr Met His Arg Leu Val Asp Arg 1380 1385 1390 Asp Glu Asn Gly Leu Ser Asn Tyr Ala Leu Ala Ala Leu Arg Pro Asn 1395 1400 1405 Lys Met Gly Leu Thr Wing Asp Asn Val Phe Asp Tyr Val Wing Ser Val 1410 1415 1420 Ser Glu Wing Ser Gly Glu Phe Leu Glu He Val Asn Tyr Asn Leu Wing 1425 1430 1435 1440 Gly Leu Gln Tyr Wing Ala Wing Gly Thr Gln Wing Gly Leu Wing Wing Leu 1445 1450 1455 Arg Wing Asp Val Glu Asn Arg Wing Pro Gly Gln Arg Ala Phe He Leu 1460 1465 1470 He Pro Gly He Asp Val Pro Phe His Ser Ser Lys Leu Arg Asp Gly 1475 1480 1485 Val Gly Ala Phe Arg Glu His Leu Asp Ser Leu He Pro Ala Glu Leu 1490 1495 1500 Asp Leu Asp Val Leu Val Gly Arg Tyr He Pro Asn Leu Val Wing Arg 1505 1510 1515 1520 Pro Phe Glu Leu Thr Glu Glu Phe Val Wing Ser Met Wing Glu Val Val 1525 1530 1535 Glu Ser Thr Tyr Val Asn Glu He Leu Ala Asp Phe Lys Ala Ala Ser 1540 1545 1550 Wing Asp Lys Gln Lys Leu Wing Arg Thr Leu Leu He Glu Leu Leu Wing 1555 1560 1565 Trp Gln Phe Wing Ser Pro Val Arg Trp He Glu Thr Gln Asp Leu Leu 1570 1575 1580 He Lys Gly Leu Gln Wing Glu Arg Phe Val Glu Val Gly Val Gly Ser 1585 1590 1595 1600 Wing Pro Thr Leu Wing Asn Met Met Gly Gln Thr Leu Arg Leu Pro Gln 1605 1610 1615 Tyr Wing Asp Wing Thr He Glu Val Leu Asn He Glu Arg Asp Arg Pro 1620 1625 1630 Val Val Phe Ala Thr Asp Glu Val Val Arg Glu Val Val Val Glu Glu 1635 1640 1645 Thr Pro Wing Wing Pro Wing Glu Thr Thr Glu Thr Pro Wing Thr Pro Wing 1650 1655 1660 Thr Pro Pro Wing Val Wing Wing Wing Wing Pro Thr Wing Gly Pro Arg 1665 1670 1675 1680 Pro Asp Asp Be Ser Phe Thr Pro Ser Asp Wing Thr Glu Met Leu He 1685 1690 1695 Wing He Trp Thr Lys Val Arg Pro Asp Gln Met Gly Ala Thr Asp Ser 1700 1705 1710 He Glu Thr Leu Val Glu Gly Val Ser Ser Arg Arg Asn Gln Leu Leu 1715 1720 1725 Leu Asp Leu Gly Val Glu Phe Gly Leu Gly Ala He Asp Gly Ala Ala 1730 1735 1740 Asp Wing Glu Leu Gly Asp Leu Lys Val Thr Val Ser Lys Met Wing Lys 1745 1750 1755 1760 Gly Tyr Lys Wing Phe Gly Pro Val Leu Ser Asp Wing Wing Wing Asp Wing 1765 1770 1775 Leu Arg Arg Leu Thr Gly Pro Thr Gly Lys Arg Pro Gly Tyr He Ala 1780 1785 1790 Glu Arg Val Thr Gly Thr Trp Glu Leu Gly Gln Gly Trp Wing Asp His 1795 1800 1805 Val Val Ala Glu Val Val He Gly Ala Arg Glu Gly Ala Ser Leu Arg 1810 1815 1820 Gly Gly Asp Leu Wing Ser Leu Ser Pro Wing Ser Pro Wing Ser Wing Ser 1825 1830 1835 1840 Asp Leu Asp Ser Leu He Asp Wing Wing Val Gln Wing Val Wing Ser Arg 1845 1850 1855 Arg Gly Val Wing Val Ser Leu Pro Be Wing Gly Wing Wing Wing Gly Gly 1860 1865 1870 Val Val Asp Be Wing Wing Leu Gly Glu Phe Wing Glu Gln Val Thr Gly 1875 1880 1885 His Asp Gly Val Leu Wing Gln Wing Wing Arg Thr He Leu Thr Gln Leu 1890 1895 1900 Gly Leu Asp Lys Pro Wing Thr Val Ser Val Glu Asp Thr Wing Glu Glu 1905 1910 1915 1920 Asp Leu Tyr Glu Leu Val Ser Lys Glu Leu Gly Ser Asp Trp Pro Arg 1925 1930 1935 Gln Val Wing Pro Ser Phe Asp Glu Glu Lys Val Val Leu Leu Asp Asp 1940 1945 1950 Arg Trp Wing Being Wing Arg Glu Asp Leu Being Wing Leu Leu Leu Wing Asn 1955 1960 1965 Being Gln Gln Leu He Being Met Being Gln Wing Gln Wing Lys Leu Leu Gln 1970 1975 1980 His Lys Leu Asn Ser Leu Asp Leu Met He Ser Gln Leu Gly Ser Arg 1985 1990 1995 2000 Thr Lys Leu Leu Gly Leu Arg Arg Gln Cys Cys Gly 2005 2010 < 210 > 51 < 211 > 2185 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (2185) < 223 > FRXA00158 cgtigcca "ttt 'tctttacaaa aigagt¡attaa ccgaaaiette aggtcaggat <; cacgccctg 60 cgt" tcaticcc iggct¡aagtta tacaatggagt z gagttetcae gtg acc gaa ttg age 115 Val Thr Glu Leu Ser 1 5 agg aac ttc ggg gcc age cga ctg att aac cgc ttt ggc cag gag ect 163 Arg Asn Phe Gly Wing Being Arg Leu He Asn Arg Phe Gly Gln Glu Pro 10 15 20 ttt gcc ttc gct ttc gcc ggc ca gga tat gac tgg ttg aag acc ctt 211 Phe Ala Phe Ala Phe Ala Gly Gln Gly Tyr Asp Trp Leu Lys Thr Leu 25 30 35 cgt gcc gcg gtt gcc gca ggt gca ggc acc aat gtt agt gac ate gtc 259 Arg Ala Ala Ala Ala Ala Gly Ala Gly Thr Asn Val Ser Asp He Val 40 45 50 gag cgc gca aat gcg ctg ctt gca cta gtt gca gat gat etc att ggc 307 Glu Arg Wing Asn Wing Leu Leu Wing Leu Val Wing Asp Asp Leu He Gly 55 60 65_ acc ctt cca ttt ggt ttc gat cca gtg gct tgg gct aac aac tcc gaa 355 Thr Leu Pro Phe Gly Phe Asp Pro Val Wing Trp Wing Asn Asn Ser Glu 70 75 80 85 gat cca gct ttc gat act gca caa tet gca gtg age gtg ccg ggt ate 403 Asp Pro Wing Phe Asp Thr Wing Gln Ser Wing Val Ser Val Pro Gly He 90 95 100 ttt gtc tcc cag ate gca acc ctg gat tcc ctt gag gcg cag cgc ctt 451 Phe Val Ser Gln He Wing Thr Leu Asp Ser Leu Glu Wing Gln Arg Leu 105 110 115 gat gtg gat cag gct gtg tcc age att ggt cat tcc cag ggc gta ttg 499 Asp Val Asp Gln Wing Val Ser Ser He Gly His Ser Gln Gly Val Leu 120 125 130 ggc gtg falls ctg etc aat gat gcg act cgt gct gat gaa etc gtt gcc 547 Gly Val His Leu Leu Asn Asp Wing Thr Arg Wing Asp Glu Leu Val Wing 135 140 145 att gcg cag ttg ate ggt gca gcg ate acc cgc acc gca cgc atg acg 595 He Wing Gln Leu He Gly Wing Wing He Thr Arg Thr Wing Arg Met Thr 150 155 160 165 ggc ctg ate gcg cag ggc gac aac atg ccg atg ctg tcg ate gcc gga 643 Gly Leu He Wing Gln Gly Asp Asn Met Pro Met Leu Ser He Wing Gly 170 175 180 att tcc cgc gag cag ctt cag ca gct ate gac gcg gcc tgc gcc gaa 691 He is Arg Glu Gln Leu Gln Gln Wing He Asp Wing Wing Cys Wing Glu 185 190 195 gtc ect gcg gag ate cgc ccg gtt ate ggt ctg cgc aac tea cgc gat 739 Val Pro Wing Glu He Arg Pro Val He Gly Leu Arg Asn Ser Arg Asp 200 205 210 tet tat gtt ttg gtt ggc cgc cca gac gac aac gct cgc gtt gtt aag 787 Ser Tyr Val Leu Val Gly Arg Pro Asp Asp Asn Ala Arg Val Val Lys 215 220 225 gtc att gag gca atg gct gcc aag gat aag aag gcc att gaa gat aag 835 Val He Glu Ala Ala Ala Ala Lys Asp Lys Lys Ala He Glu Asp Lys 230 235 240 245 ctg cgc ggc ggt tcc gcg ttc age ccc cgt att act ccg ctg aag gtg 883 Leu Arg Gly Gly Be Wing Phe Ser Pro Arg He Thr Pro Leu Lys Val 250 255 260 cag gct gct ttc cat drops cca gct atg aac atg gct gtg gag cag acc 931 Gln Ala Ala Phe His His Pro Wing Met Asn Met Wing Val Glu Gln Thr 265 270 275 gtg gcg tgg gca acc act gct ggt ttg gat gtg gaa etc acc cgc gag 979 Val Ala Trp Ala Thr Thr Ala Gly Leu Asp Val Glu Leu Thr Arg Glu 280 285 290 ate gcc gct gat gtt ttg gtt aac ect gtc gat tgg gta gca cgc gtc 1027 Wing wing Wing Asp Val Leu Val Asn Pro Val Asp Trp Val Wing Arg Val 295 300 305 aac gaa gcg tat gag gct ggc gct cgc tgg ttc etc gac gtt gga cca 1075 Asn Glu Ala Tyr Glu Ala Gly Ala Arg Trp Phe Leu Asp Val Gly Pro 310 315 320 325 gat ggt ggc ate gtt aag ctg act gcc aac ate ctt gag ggc cgc ggc 1123 Asp Gly Gly He Val Lys Leu Thr Wing Asn He Leu Glu Gly Arg Gly 330 335 340 gcg gat tcc ttc tat gtt ggt gac gcc gca ggc cag gcc aag ata ttt 1171 Wing Asp Ser Phe Tyr Val Gly Asp Wing Wing Gly Gln Wing Lys He Phe 345 350 355 gat gct ggc atg gca ect gaa ctt cca gtg gat tac cag gag ttc gca 1219 Asp Wing Gly Met Wing Pro Glu Leu Pro Val Asp Tyr Gln Glu Phe Wing 360 365 370 cca cgc gtt gag falls gtt gat gga acc cca cgc ctg gtt acc aag ttc 1267 Pro Arg Val Glu His Val Asp Gly Thr Pro Arg Leu Val Thr Lys Phe 375 380 385 act gag ctg acc ggc cgc acc cca atg atg ctg gct ggc atg acc cca 1315 Thr Glu Leu Thr Gly Arg Thr Pro Met Met Leu Wing Gly Met Thr Pro 390 395 400 405 acc acc gtt gac ect gcc att gtt gca gcc gct gca aac ggt gga falls 1363 Thr Thr Val Asp Pro Wing Ala Val Wing Wing Wing Wing Asn Gly Gly His 410 415 420 tgg gct gag gct ggt ggc gg gg cag gt acc accc gag ctg gag ctg gaa 1411 Trp Wing Glu Leu Wing Gly Gly Gly Gln Val Thr Pro Glu Leu Leu Glu 425 430 435 acc falls gca gg cag etc acc gac atg ctt gag cca ggt ate aac gcc 1459 Thr His He Wing Gln Leu Thr Asp Met Leu Glu Pro Gly He Asn Wing 440 445 450 cag ttc aac tc tc tc tg tc tc tc tc tc tg a tg atg cag att 1507 Gln Phe Asn Ser Met Phe Leu Asp Pro Tyr Leu Trp Lys Met Gln He 455 460 465 ggt ggc aag cgc ctt gtt ect aag gcc cgc gct aat ggt gca tcc ate 1555 Gly Gly Lys Arg Leu Val Pro Lys Wing Arg Wing Asn Gly Wing Wing He 470 475 480 485 gac ggc ate gtc ate gcc gcc gtc att ect gaa aag gat gaa gct gtt 1603 Asp Gly He Val He Thr Wing Gly He Pro Glu Lys Asp Glu Wing Val 490 495 500 gca ttg gtc aag gaa ctg atg cgt gat ggt ttc ect tgg ate gca ttc 1651 Wing Leu Val Lys Glu Leu Met Arg Asp Gly Phe Pro Trp He Wing Phe 505 510 515 aag cca ggt gcc ate aag cag gtt aac tet gtg ttg gct ate gct aag 1699 Lys Pro Gly Ala He Lys Gln Val Asn Ser Val Leu Ala He Ala Lys 520 525 530 gaa gtt cca gaa etc ccc ate ate att cag att gag ggt ggc gtt gca gca 1747 Glu Val Pro Glu Leu Pro He He He He Gln He Glu Gly Gly Val Wing 535 540 545 ggt gga falls falls tet tgg gaa gac etc gat gag ctg ctg ate gcc acc 1795 Gly Gly His His Ser Trp Glu Asp Leu Asp Glu Leu Leu He Wing Thr 550 555 560 565 tac ggc aag gtc cgc gca ctg gat aac gtg gtg ctg tgt gtc ggc ggt 1843 Tyr Gly Lys Val Arg Ala Leu Asp Asn Val Val Leu Cys Val Gly Gly 570 575 580 ggc att ggc tea ect gag cgc gct gct gat tac gtc acc ggt tcc tgg 1891 Gly He Gly Ser Pro Glu Arg Wing Wing Asp Tyr Val Thr Gly Ser Trp 585 590 595 tcc act tcc tac ggc ctg cca gct atg ect gtt gat ggc ate ttg gtg 1939 Ser Thr Ser Tyr Gly Leu Pro Wing Met Pro Val Asp Gly He Leu Val 600 605 610 ggt acc gct gcg atg gca acc aag gaa gca acc acc tcc cag gcc gtc 1987 Gly Thr Wing Wing Met Wing Thr Lys Glu Wing Thr Thr Ser Gln Wing Val 615 620 625 aag gaa ctt ctt gtt tcc acc ggc cag tet gat gaa tgg gtt ect gct 2035 Lys Glu Leu Leu Val Ser Thr Gln Gly Ser Asp Glu Trp Val Pro Wing 630 635 640 645 ggt ggc gca aag aac gga atg gca tat ggc cgt tcc cag ctt ggc gca 2083 Gly Gly Wing Lys Asn Gly Met Wing Tyr Gly Arg Ser Gln Leu Gly Wing 650 655 660 gac tettle gag ate gac aac tcc ttt gct aag gct gga cgc ctt ctt 2131 Asp He His Glu He Asp Asn Ser Phe Ala Lys Ala Gly Arg Leu Leu 665 670 675 gat gag gtt gca ggc cat gaa acg gat ttg cac gcg cgc ccg gat gag 2179 Asp Glu Val Wing Gly His Glu Thr Asp Leu Gln Wing Arg Pro Asp Glu 680 685 690 att att 2185 He He 695 <; 210 > 52 < 211 > 695 < 212 > PRT *. á 1 4 jáiá & ^ aagffa? fift < 213 > Corynebacterium glutamicum < 400 > 52 Val Thr Glu Leu Ser Arg Asn Phe Gly Wing Ser Arg Leu He Asn Arg 1 5 10 15 Phe Gly Gln Glu Pro Phe Wing Phe Wing Phe Wing Gly Gln Gly Tyr Asp 20 25 30 Trp Leu Lys Thr Leu Arg Wing Wing Val Wing Wing Gly Wing Gly Thr Asn 35 40 45 Val Ser Asp He Val Glu Arg Wing Asn Wing Leu Leu Wing Leu Val Wing 50 55 60 Asp Asp Leu He Gly Thr Leu Pro Phe Gly Phe Asp Pro Val Wing Trp 65 70 75 80 Wing Asn Asn Ser Glu Asp Pro Wing Phe Asp Thr Wing Gln Ser Wing Val 85 90 95 Ser Val Pro Gly He Phe Val Ser Gln He Wing Thr Leu Asp Ser Leu 100 105 110 Glu Wing Gln Arg Leu Asp Val Asp Gln Wing Val Ser Ser He Gly His 115 120 125 Ser Gln Gly Val Leu Gly Val His Leu Leu Asn Asp Ala Thr Arg Ala 130 135 140 Asp Glu Leu Val Ala Ala Ala Gln Leu He Gly Ala Ala He Thr Arg 145 150 155 160 Thr Ala Arg Met Thr Gly Leu He Wing Gln Gly Asp Asn Met Pro Met 165 170 175 Leu Ser He Wing Gly He Ser Arg Glu Gln Leu Gln Gln Wing He Asp 180 185 190 Wing Wing Cys Wing Glu Val Pro Wing Glu He Arg Pro Val He Gly Leu 195 200 205 Arg Asn Ser Arg Asp Ser Tyr Val Leu Val Gly Arg Pro Asp Asp Asn 210 215 220 Wing Arg Val Val Lys Val He Glu Wing Ala Wing Wing Lys Asp Lys Lys 225 230 235 240 Wing He Glu Asp Lys Leu Arg Gly Gly Be Wing Phe Ser Pro Arg He 245 250 255 Thr Pro Leu Lys Val Gln Wing Wing Phe His His Pro Wing Met Asn Met 260 265 270 Wing Val Glu Gln Thr Val Wing Trp Wing Thr Thr Wing Ala Gly Leu Asp Val 275 280 285 Glu Leu Thr Arg Glu He Ala Wing Asp Val Leu Val Asn Pro Val Asp 290 295 300 Trp Val Wing Arg Val Asn Glu Wing Tyr Glu Wing Gly Wing Arg Trp Phe 305 310 315 320 Leu Asp Val Gly Pro Asp Gly Gly He Val Lys Leu Thr Ala Asn He 325 330 335 Leu Glu Gly Arg Gly Wing Asp Ser Phe Tyr Val Gly Asp Wing Wing Gly 340 345 350 Gln Wing Lys He Phe Asp Wing Gly Met Wing Pro Glu Leu Pro Val Asp 355 360 365 Tyr Gln Glu Phe Wing Pro Arg Val Glu His Val Asp Gly Thr Pro Arg 370 375 380 Leu Val Thr Lys Phe Thr Glu Leu Thr Gly Arg Thr Pro Met Met Leu 385 390 395 400 Wing Gly Met Thr Pro Thr Thr Val Asp Pro Wing He Val Wing Wing Wing 405 410 415 Wing Asn Gly Gly His Trp Wing Glu Leu Wing Gly Gly Gly Gln Val Thr 420 425 430 Pro Glu Leu Leu Glu Thr His He Wing Gln Leu Thr Asp Met Leu Glu 435 440 445 Pro Gly He Asn Wing Gln Phe Asn Being Met Phe Leu Asp Pro Tyr Leu 450 455 460 Trp Lys Met Gln He Gly Gly Lys Arg Leu Val Pro Lys Wing Arg Wing 465 470 475 480 Asn Gly Wing Be He Asp Gly He Val He Thr Wing Gly He Pro Glu 485 490 495 Lys Asp Glu Wing Val Ala Leu Val Lys Glu Leu Met Arg Asp Gly Phe 500 505 510 Pro Trp He Wing Phe Lys Pro Gly Wing He Lys Gln Val Asn Ser Val 515 520 525 Leu Wing He Wing Lys Glu Val Pro Glu Leu Pro He He He Gln He 530 535 540 Glu Gly Gly Val Wing Gly Gly His Ser Trp Glu Asp Leu Asp Glu 545 550 555 560 Leu Leu He Wing Thr Tyr Gly Lys Val Arg Wing Leu Asp Asn Val Val 565 570 575 Leu Cys Val Gly Gly Gly He Gly Ser Pro Glu Arg Wing Wing Asp Tyr 580 585 590 Val Thr Gly Ser Trp Ser Thr Ser Tyr Gly Leu Pro Wing Met Pro Val 595 600 605 Asp Gly He Leu Val Gly Thr Wing Wing Met Wing Thr Lys Glu Wing Thr 610 615 6 20 Thr Ser Gln Wing Val Lys Glu Leu Leu Val Ser Thr Gln Gly Ser Asp 625 630 635 640 Glu Trp Val Pro Wing Gly Gly Wing Lys Asn Gly Met Wing Tyr Gly Arg 645 650 655 Ser Gln Leu Gly Wing Asp He His Glu He Asp Asn Ser Phe Ala Lys 660 665 670 Wing Gly Arg Leu Leu Asp Glu Val Wing Gly His Glu Thr Asp Leu Gln 675 680 685 Wing Arg Pro Asp Glu He He 690 695 < 210 > 53 < 211 > 3831 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (3831) < 223 > FRXA00572 < 400 > 53 cag tgg etc aac cgc tac etc gag ctg tet ggc ect gtt gat ggt cag 48 Gln Trp Leu Asn Arg Tyr Leu Glu Leu Ser Gly Pro Val Asp Gly Gln 1 5 10 15 tgg att gat gct tcc tgg gct gca cgt ttt gcc cag atg ctg gag cgt 96 Trp He Asp Wing Ser Trp Wing Wing Arg Phe Wing Gln Met Leu Glu Arg 20 25 30 gcc gag gcg cgt ttg ate gag cag gat cat ggc cata ttt gag cca age 144 Wing Glu Wing Arg Leu He Glu Gln Asp His Gly Gln Phe Glu Pro Ser 35 40 45 ctg acg gtg gag gat ggc gtc gac aag ctt gtt gct gct tac ccg cat 192 Leu Thr Val Glu Asp Gly Val Asp Lys Leu Val Ala Ala Tyr Pro His . & I á - 50 55 60 gcc gca acc gac ctg etc acc ccg gct gat gtc gcc tgg ttc ttg ggc 240 Wing Wing Thr Asp Leu Leu Thr Pro Wing Asp Val Wing Trp Phe Leu Gly 65 70 75 80 ctg tgc cgc acg ccg ggc aag ect gtg aac ttt gtg ccc gtc att gat 288 Leu Cys Arg Thr Pro Gly Lys Pro Val Asn Phe Val Pro Val He Asp 85 90 95 aag gac gtg cgc cgc tgg tgg cgc tcg gac tcc ctg tgg cg tcc crash 336 Lys Asp Val Arg Arg Trp Trp Arg Ser Asp Ser Leu Trp Gln Ser His 100 105 110 gat gat cgc tac acc gct gat cag gtg gct att ate ect ggt gtc gtc 384 Asp Asp Arg Tyr Thr Wing Asp Gln Val Wing He He Pro Gly Val Val 115 120 125 gcc gtt gct gct gcc ate acc aag gcc aac gaa ect gtc gct gac ctg ctt 432 Wing Val Wing Gly He Thr Lys Wing Asn Glu Pro Val Wing Asp Leu Leu 130 135 140 gat cgc ttt gtc gac gcc acc ate gag cgc ate gat gag falls gat tcc 480 Asp Arg Phe Val Asp Wing Thr He Glu Arg He Asp Glu His Asp Ser 145 150 155 160 cgc tcc cgc gac ate atg ggc aaa gtg ctt tcc tea ect ggc here ttc 528 Arg Ser Arg Asp He Met Gly Lys Val L Eu Ser Ser Pro Gly Thr Phe 10 165 170 175 tgg ggc cgc aac ate cca tcg gtg ate age ctt ggg ggg cat gct 576 • Trp Wing Gly Arg Asn He Pro Ser Val He His Ser Leu Gly His Wing 180 185 190 gac aag tgg tcc cgc tcc gaa ttc gaa gca ttc cat age cca acc ggc 624 Asp Lys Trp Ser Arg Ser Glu Phe Glu Wing Phe His Ser Pro Thr Gly 195 200 205 gcc aac ttg gtg tac gaa gac gcc gag drops gcg atg ctg act gtg ect 672 Wing Asn Leu Val Tyr Glu Asp Wing Glu His Wing Met Leu Thr Val Pro 210 215 220 ttg gcg ggt tcc acc gca ttc ggc acc acc gct gag ctg aaa ate cgt 720 15 Leu Wing Gly Ser Thr Wing Phe Gly Thr Thr Wing Glu Leu Lys He Arg 225 230 235 240 ttc acc age ccc ate gac gct ctg cca age gct gcc cca ctg gtc acc 768 Phe Thr Ser Pro He Asp Ala Leu Pro Ser Ala Val Pro Leu Val Thr 245 250 255 cag gaa gac gct gaa gcc gcg atg ggt gaa ctg acc cgc ate gca gct 816 Gln Glu Asp Wing Glu Wing Wing Met Gly Glu Leu Thr Arg He Wing Wing 260 265 270 ggc ggc acc ctg gca act gtg aac aat ggc acc gct acc tgg gaa acc 864 Gly Gly Thr Leu Wing Thr Val Asn Asn Gly Thr Wing Thr Trp Glu Thr 275 280 285 tcc gtc gc gc gc gc gc gc gc gc gc gc gc gcc cc gcc cc gcc accc gcc 912 20 Ser Val Asp Wing Gly Val He Wing Asp Tyr Asn Asn Val Thr Ala Gly 290 295 300 tac ctg cca gca tcc gtt gtt ect gca falls acc gca ect gac gtg ctg 960 Tyr Leu Pro Wing Val Val Pro Pro Wing His Thr Wing Pro Asp Val Leu 305 310 315 320 gtt ggc cgc gca tgg cca gca gtt ttc gct gcc gta aag tcc gca gtc 1008 Val Gly Arg Wing Trp Pro Wing Val Phe Wing Wing Val Lys Ser Wing Val 325 330 335 ate cca ggc acc gat tcc gcc gtt gtg gaa ggc atg ctg tcc ctg 1056 He Pro Gly Thr Asp Ser Ala Ser Val Val Glu Gly Met Leu Ser Leu 340 345 350 gtt falls ctg gag falls falls att gtg etc aag tcc gat gtc cca acc gac 1104 25 Val His Leu Glu His His He Val Leu Lys Ser Asp Val Pro Thr Asp »^ Af 355 360 365 ggc gcg ctg aag gtt tcc gcg act gcc gat gag gta gtc gat acc gac 1152 Gly Ala Leu Lys Val Ser Wing Thr Wing Asp Glu Val Val Asp Thr Asp 370 375 380 ctg ggt cgc etc gtg ate gtg cgc gca gaa ate gcc gac gca gaa ggc 1200 Leu Gly Arg Leu Val He Val Arg Ala Glu He Ala Asp Ala Glu Gly 385 390 395 400 aac ctg att gct acg ttg gct gag cgt ttc gcg ate cgc gga cgc aag 1248 Asn Leu He Wing Thr Leu Wing Glu Arg Phe Wing He Arg Gly Arg Lys 405 410 415 ggc aac gct gtc gca cgc acc aac acc tcc gca ctg cca acc acc gtg 1296 Gly Asn Wing Val Wing Arg Thr Asn Thr Ser Wing Leu Pro Thr Thr Val 420 425 430 gac acc cca cgc tea gct cgc gca gtg gca acc gtt gtt gca ect gaa 1344 Asp Thr Pro Arg Ser Wing Arg Wing Val Wing Thr Val Val Wing Pro Glu 435 440 445 tcc atg cgc cca ttc gct gtg ate tcc ggt gac cgc aac cca att cae 1392 Be Met Arg Pro Phe Wing Val He Be Gly Asp Arg Asn Pro He His 450 455 460 gtc tet gat gtt gcg gct tcc ctg gct ggt ctg cca ggt gtg ate gtg 1440 jyal Ser Asp Val Ala Ala Ser Leu Ala Gly Leu Pro Gly Val He Val 465 470 475 480 falls ggc atg tgg acc tet gcc ate ggt gaa ctg ate gcc ggt gca gca gca 1488 His Gly Met Trp Thr Ser Wing He Gly Glu Leu He Wing Gly Wing Wing 485 490 495 ttc aac gat gag cag ate cac act ccc gca gcc aag gtc gtg gaa tac 1536 Phe Asn Glu Gln He Gln Thr Pro Wing Ala Lys Val Val Glu Tyr 500 505 510 acc gca acc atg ctg gca cca gtt ctt cca ggt gaa gaa att gag ttc 1584 Thr Wing Thr Met Leu Wing Pro Val Leu Pro Gly Glu Glu He Glu Phe 515 520 525 age gtt gag cgc tcc gca gtg gac aac cgc cca gga atg gga gag gtc 1632 Ser Val Glu Arg Ser Wing Val Asp Asn Arg Pro Gly Met Gly Glu Val 530 535 540 cgc acc gtt acc gca acc gtc aac ggc aac tta gtg ctt acc gcc acc 1680 Arg Thr Val Thr Wing Thr Val Asn Gly Asn Leu Val Leu Thr Wing Thr 545 550 555 560 gct gtt gtg gca gct cca tet act ttc tac gca tcc cca ggc cag ggc 1728 Ala Val Val Ala Ala Pro Ser Thr Phe Tyr Ala Phe Pro Gly Gln Gly 565 570 575 att cag tcc cag ggc atg ggt atg gaa gca cgc cgt aac tet cag gca 1776 He Gln Ser Gln Gly Met Gly Met Glu Wing Arg Arg Asn Ser Gln Wing 580 585 590 gct cgc gct ate tgg gac cgc gcc gat gca falls acc cgc aat aag ctg 1824 Wing Arg Wing He Trp Asp Arg Wing Asp Wing His Thr Arg Asn Lys Leu 595 600 605 ggc ttc tcc ate gtg gaa ate gtg gaa aac aac cca cgc gaa gta acc 1872 Gly Phe Ser He Val Val Glu He Val Glu Asn Asn Pro Arg Glu Val Thr 610 615 620 gtg gca ggg gag aag ttc ttc falls cca gac ggc gtt ttg tac etc acc 1920 Val Ala Gly Glu Lys Phe Phe His Pro Asp Gly Val Leu Tyr Leu Thr 625 630 635 640 cag ttc acc cag gtg ggc atg gca act ctg ggc gtt gct cag ate gct 1968 Gln Phe Thr Gln Val Gly Met Wing Thr Leu Gly Val Wing Gln He Wing 645 650 655 gaa atg cgt gaa gca cat gcc ttg aac cag cgt gca tac ttt gct gga 2016 Glu Met Arg Glu Ala His Ala Leu Asn Gln Arg Ala Tyr Phe Ala Gly 660 665 670 falls tcc gtt ggt gag tac aac gcg ctt gct gca tat gct ggt gtg ctg 2064 His Ser Val Gly Glu Tyr Asn Ala Leu Ala Ala Tyr Ala Gly Val Leu 675 680 685cc ctg gaa tcc gtt ctg gag ate gtt tac cgt cgt ggc ttg acc atg 2112 Ser Leu Glu Ser Val Leu Glu He Val Tyr Arg Arg Gly Leu Thr Met 690 695 700 falls cgc ttg gtg gat cgc gat gaa aac ggt ctg tcc aac tac gcg etc 2160 His Arg Leu Val Asp Arg Asp Glu Asn Gly Leu Ser Asn Tyr Ala Leu 705 710 715 720 gca gct ctt cgc ccc aac aag atg ggt ctg acc gca gac aac gtt ttc 2208 Ala Ala Leu Arg Pro Asn Lys Met Gly Leu Thr Wing Asp Asn Val Phe 725 730 735 gat tac gtt gcg tet gtt tcc gaa gct tcc ggt gaa ttc ctg gag ate 2256 Asp Tyr Val Wing Ser Val Ser Glu Wing Ser Gly Glu Phe Leu Glu He 740 745 750 gtt aac tac aac ttg gct ggc ctg cag tac gca gtt gct gga acc cag 2304 Val Asn Tyr Asn Leu Wing Gly Leu Gln Tyr Wing Val Wing Gly Thr Gln 755 760 765 gct gtt ctt gcc gcc ctt cgt gcc gat gtt gag aac cgt gca cca ggt 2352 Ala Gly Leu Ala Ala Leu Arg Ala Asp Val Glu Asn Arg Ala Pro Gly 770 775 780 cag cgt gcc ttc att ttg ate ect ggc att gac gtg cca ttc falls tcc 2400 Gln Arg Ala Phe He Leu He Pro Gly He Asp Val Pro Phe His Ser 785 790 795 800 tcc aag ctg cgc gac ggt gtg ggc gcg ttc cgt gag falls ctt gat tcc 2448 Ser Lys Leu Arg Asp Gly Val Gly Wing Phe Arg Glu His Leu Asp Ser 805 810 815 ctg ate cca gct gag ctg gat ctg gat gtg ctg gtt ggc cgc tac att 2496 Leu He Pro Wing Glu Leu Asp Leu Asp Val Leu Val Gly Arg Tyr He 820 825 830 cca aac ttg gtg gct cgc cca ttc gaa etc act gaa gag ttc gtg gca 2544 Pro Asn Leu Val Wing Arg Pro Phe Glu Leu Thr Glu Glu Phe Val Wing 835 840 845 tcc atg gca gaa gtg gtg gag tcc acc tat gtc aat gag ate ttg gct 2592 Ser Met Wing Glu Val Val Glu Ser Thr Tyr Val Asn Glu He Leu Wing 850 855 860 gat ttc aag gct gct tcc gcc gat aag cag aag ctt gcc cgc acg ttg 2640 Asp Phe Lys Wing Wing Being Wing Asp Lys Gln Lys Leu Wing Arg Thr Leu 865 870 875 880 ctt att gag ctg ctt gca tgg cag ttc gca tea ect gtg cgc tgg ate 2688 Leu He Glu Leu Leu Wing Trp Gln Phe Wing Being Pro Val Arg Trp He 885 890 895 gag act cag gat ctg ttg ate aag ggc ctt ca gct gag cgt ttc gtg 2736 Glu Thr Gln Asp Leu Leu He Lys Gly Leu Gln Wing Glu Arg Phe Val 900 905 910 gag gtc ggt gtt ggc tet gct cca acg ctt gcc aac atg ggc cag 2784 Glu Val Gly Val Gly Ser Ala Pro Thr Leu Ala Asn Met Met Gly Gln 915 920 925 ctc cct cct cct ect cag tac gcg gac gcc acc att gag gtg tta aac 2832 Thr Leu Arg Leu Pro Gln Tyr Wing Asp Wing Thr He Glu Val Leu Asn 930 935 940 att gag cgc gat cgc cca gtt gtg ttc gct acc gat gag gtt gtg cgt 2880 He Glu Arg Asp Arg Pro Val Val Phe Wing Thr Asp Glu Val Val Arg 945 950 955 960 gaa gtg gcg gtt gaa gag acc cca gca gct ect gca gaa acc act gaa 2928 Glu Val Wing Val Glu Glu Thr Pro Wing Wing Pro Wing Glu Thr Thr Glu 965 970 975 acc cca gca acc cca gca acc cca gcc ect gtt gca gct gca gcc ect 2976 Thr Pro Wing Thr Pro Wing Thr Pro Wing Pro Val Wing Wing Wing Pro 980 985 990 gcc ggc ggc ect cgc ccac gat gac ate age ttc act ect tet gat 3024 Wing Thr Gly Gly Pro Arg Pro Asp Asp He Ser Phe Thr Pro Ser Asp 995 1000 1005 gcc act gaa atg etc ate gct ate tgg acc aag gtt cgc cca gat cag 3072 Wing Thr Glu Met Leu He Wing He Trp Thr Lys Val Arg Pro Asp Gln 1010 1015 1020 atg ggt gcc act gat tcc ate gag acc ctg gtt gag ggc gtg tcc tet 3120 Met Gly Wing Thr Asp Ser He Glu Thr Leu Val Glu Gly Val Ser Ser 1025 1030 1035 1040 cgc cgc aac cag etc ctg ctg gat ctt ggt gtg gag ttc ggc ggc etc ggc 3168 Arg Arg Asn Gln Leu Leu Asu Leu Gly Val Glu Phe Gly Leu Gly 1045 1050 1055 gca att gac gga gca gcc gat gct gag eettcc ggqgtt ggaatt ccttaa aaaaqg ggttcc aacccc 3216 Ala He Asp Gly Ala Ala Asp Wing Glu Leu Gly Asp Leu Lys Val Thr 1060 1065 gtg 1070 gtg ct aag atg gct aag ggc tac aag ggccgg tttttt ggqgcc eecctt ggttgg eettcc ttcccc 3264 Val Ser Lys Met Wing Lys Gly Tyr Lys Wing Phe Gly Pro Val Leu Ser 1075 1080 1085 gat gct gca gct gat gcc ctg cgt cgc eettcc aacctt ggggtt eecctt aacccc ggggtt aaaagg 3312 Asp Wing Wing Wing Asp Wing Leu Arg Arg Leu Thr Gly Pro Thr Gly Lys 1090 1095 1100 cgc cgc gga tac ate gca gag cgc gtc acc ggc acg tgg gag tgc ggc 3360 Arg Pro Gly Tyr He Wing Glu Arg Val Thr Gly Thr Trp Glu Leu Gly 1105 1110 1115 1120 cag ggc tgg gct gac drops gtg gtc gct gaa gtt gtg ate ggc gcc cgc 3408 Gln Gly Trp Wing Asp His Val Val Wing Glu Val Val He Gly Wing Arg 1125 1130 1135 gaa ggc gca tcc ccttgg ccggcc ggggcc ggggcc ggaacc ccttgg ggccgg tteeaa ccttgg tteett eecctt ggccaa 3456 Glu Gly Ala Ser Leu Arg Gly Gly Asp L Leeuu A Allaa S Seerr LLeeuu SSeerr PPrroo AAllaa 1140 1145 11115500 age cca gcg tet gca tea gat ctt gat tcg ctt ate gac ggccaa ggcccc ggttcc 3504 Ser Pro Ala Ser Ala Ser Asp Leu Asp Ser Leu He Asp AAllaa VVaall 1155 1160 1165 cag gcc gta gcc tcc cgc cgc ggc gtt gcg gtc tcc ctg eecctt tteeaa ggccaa 3552 Gln Ala Val Ala Ser Arg Arg Gly Val Wing Val Ser Leu PPrroo SSeerr AAllaa 1170 1175 1180 ggc ggc gct gcc ggt ggc gtg gtt gat tcc gca gct ctt ggggcc ggaagg tttttt 3600 Gly Gly Wing Wing Gly Gly Val Val Asp Being Wing Wing Leu Gly Glu PPhhee 1185 1190 1195 1122000 gca gag cag gtc < acc gga falls gat ggt gtg cctttt ggcctt ccaagg ggccaa ggcccc ccggcc 3648 Wing Glu Gln Val '.rhr Gly His Asp Gly Val LLeeuu AAllaa GGllnn AAllaa A Allaa A Arrgg L205: L210 1 1221155 aacccc aattee ttttgg acc cag ttg ggt ctt gat aag cca gca acc gtt ttcccc ggttgg 3696 TThhrr HHee LLeeuu Thr Gln Leu Gly Leu Asp Lys Pro Wing Thr Val SSeerr VVaall 1220 1225 1230 gaa gac acc gca gag gaa gac etc tac gag ttg gtc tcc aag ggaaaa eettcc 3744 Glu Asp Thr Ala Glu Glu Asp Leu Tyr Glu Leu Val Ser Lys GGlluu LLeeuu 1235 1240 1245 ggt tet gat tgg cca cgt cag gtt gca cca age ttc gat gaa gaa aag 3792 Gly Ser Asp Trp Pro Arg Gln Val Wing Pro Ser Phe Asp Glu Glu Lys 1250 1255 1260 gtt gtt ctg ctt gat gac cgt tgg gct tet gcg cgt gag 3831 Val Val Leu Leu Asp Asp Arg Trp Wing Be Wing Arg Glu 1265 1270 1275 < 210 > 54 < 211 > 1277 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 54 Gln Trp Leu Asn Arg Tyr Leu Glu Leu Ser Gly Pro Val Asp Gly Gln 1 5 10 15 Trp He Asp Wing Being Trp Wing Wing Arg Phe Wing Gln Met Leu Glu Arg 20 25 30 Wing Glu Wing Arg Leu He Glu Gln Asp His Gly Gln Phe Glu Pro Ser 35 40 45 Leu Thr Val Glu Asp Gly Val Asp Lys Leu Val Wing Wing Tyr Pro His 50 55 60 Wing Wing Thr Asp Leu Leu Thr Pro Wing Asp Val Wing Trp Phe Leu Gly 65 70 75 80 Leu Cys Arg Thr Pro Gly Lys Pro Val Asn Phe Val Pro Val He Asp 85 90 95 Lys Asp Val Arg Arg Trp Trp Arg Ser Asp Ser Leu Trp Gln Ser His 100 105 110 Asp Asp Arg Tyr Thr Wing Asp Gln Val Wing He He Pro Gly Val Val 115 120 125 Wing Val Wing Gly He Thr Lys Wing Asn Glu Pro Val Wing Asp Leu Leu 130 135 140 Asp Arg Phe Val Asp Wing Thr He Glu Arg He Asp Glu His Asp Ser 145 150 155 160 Arg Ser Arg Asp He Met Gly Lys Val Leu Ser Ser Pro Gly Thr Phe 165 170 175 Trp Wing Gly Arg Asn He Pro Ser Val He His Ser Leu Gly His Wing 180 185 190 Asp Lys Trp Ser Arg Ser Glu Phe Glu Wing Phe His Ser Pro Thr Gly 195 200 205 Wing Asn Leu Val Tyr Glu Asp Wing Glu His Wing Met Leu Thr Val Pro 210 215 220 Leu Wing Gly Ser Thr Wing Phe Gly Thr Thr Ala Glu Leu Lys He Arg 225 230 235 240 Phe Thr Ser Pro He Asp Ala Leu Pro Ser Ala Val Pro Leu Val Thr 245 250 255 Gln Glu Asp Wing Glu Wing Wing Met Gly Glu Leu Thr Arg He Wing Wing 260 265 270 Giy Gly Thr Leu Wing Thr Val Asn Asn Gly Thr Wing Thr Trp Glu Thr 275 280 285 Ser Val Asp Wing Gly Val He Wing Asp Tyr Asn Asn Val Thr Ala Gly 290 295 300 Tyr Leu Pro Ala Ser Val Val Pro Ala His Thr Ala Pro Asp Val Leu 305 310 315 320 Val Gly Arg Ala Trp Pro Ala Val Phe Ala Ala Val Lys Ser Ala Val 325 330 335 He Pro Gly Thr Asp Ser Ala Ser Val Val Glu Gly Met Leu Ser Leu 340 345 350 Val His Leu Glu His His He Val Val Leu Lys Ser Asp Val Pro Thr Asp 355 360 365 Gly Ala Leu Lys Val Ser Ala Thr Ala Asp Glu Val Val Asp Thr Asp 370 375 380 Leu Gly Arg Leu Val He Val Arg Ala Glu He Ala Asp Ala Glu Gly 385 390 395 400 Asn Leu He Wing Thr Leu Wing Glu Arg Phe Wing He Arg Gly Arg Lys 405 410 415 Gly Asn Wing Val Wing Arg Thr Asn Thr Ser Wing Leu Pro Thr Thr Val 420 425 430 Asp Thr Pro Arg Be Wing Arg Wing Val Wing Thr Val Val Wing Pro Glu 435 440 445 Ser Met Arg Pro Phe Wing Val He Ser Gly Asp Arg Asn Pro He His 450 455 460 Val Ser Asp Val Ala Ala Ser Leu Ala Gly Leu Pro Gly Val He Val 465 470 475 480 His Gly Met Trp Thr Ser Wing He Gly Glu Leu He Wing Gly Wing Wing 485 490 495 Phe Asn Asp Glu Gln He Gln Thr Pro Wing Ala Lys Val Val Glu Tyr 500 505 510 Thr Wing Thr Met Leu Wing Pro Val Leu Pro Gly Glu Glu He Glu Phe 515 520 525 Ser Val Glu Arg Ser Wing Val Asp Asn Arg Pro Gly Met Gly Glu Val 530 535 540 Arg Thr Val Thr Wing Thr Val Asn Gly Asn Leu Val Leu Thr Ala Thr 545 550 555 560 Ala Val Val Ala Ala Pro Ser Thr Phe Tyr Ala Phe Pro Gly Gln Gly 565 570 575 He Gln Being Gln Gly Met Gly Met Glu Wing Arg Arg Asn Being Gln Wing 580 585 590 Wing Arg Wing He Trp Asp Arg Wing Asp Wing His Thr Arg Asn Lys Leu 595 600 605 Gly Phe Ser He Val Glu He Val Glu Asn Asn Pro Arg Glu Val Thr 610 615 620 Val Wing Gly Glu Lys Phe Phe His Pro Asp Gly Val Leu Tyr Leu Thr 625 630 635 640 Gln Phe Thr Gln Val Gly Met Wing Thr Leu Gly Val Wing Gln He Wing 645 650 655 Glu Met Arg Glu Ala His Ala Leu Asn Gln Arg Ala Tyr Phe Ala Gly 660 665 670 His Ser Val Gly Glu Tyr Asn Ala Leu Ala Ala Tyr Ala Gly Val Leu 675 680 685 Ser Leu Glu Ser Val Leu Glu He Val Tyr Arg Arg Gly Leu Thr Met 690 695 700 His Arg Leu Val Asp Arg Asp Glu Asn Gly Leu Ser Asn Tyr Ala Leu 705 710 715 720 Ala Ala Leu Arg Pro Asn Lys Met Gly Leu Thr Ala Asp Asn Val Phe 725 730 735 Asp Tyr Val Ala Ser Val Ser Glu Ala Ser Gly Glu Phe Leu Glu He 740 745 750 Val Asn Tyr Asn Leu Wing Gly Leu Gln Tyr Wing Val Wing Gly Thr Gln 755 760 765 Wing Gly Leu Wing Wing Leu Arg Wing Asp Val Glu Asn Arg Ala Pro Gly 770 775 780 Gln Arg Ala Phe He Leu He Pro Gly He Asp Val Pro Phe His Ser 785 790 795 800 Ser Lys Leu Arg Asp Gly Val Gly Wing Phe Arg Glu His Leu Asp Ser 805 810 815 Leu He Pro Wing Glu Leu Asp Leu Asp Val Leu Val Gly Arg Tyr He 820 825 830 Pro Asn Leu Val Wing Arg Pro Phe Glu Leu Thr Glu Glu Phe Val Wing 835 840 845 Ser Met Ala Glu Val Val Glu Ser Thr Tyr Val Asn Glu He Leu Ala 850 855 860 Asp Phe Lys Ala Wing Wing Asp Lys Gln Lys Leu Wing Arg Thr Leu 865 870 875 880 Leu He Glu Leu He Leu Wing Trp Gln Phe Wing Being Pro Val Arg Trp He 885 890 895 Glu Thr Gln Asp Leu Leu He Lys Gly Leu Gln Wing Glu Arg Phe Val 900 905 910 Glu Val Gly Val Gly Ser Wing Pro Thr Leu Wing Asn Met Met Gly Gln 915 920 925 Thr Leu Arg Leu Pro Gln Tyr Wing Asp Wing Thr He Glu Val Leu Asn 930 935 940 He Glu Arg Asp Arg Pro Val Val Phe Ala Thr Asp Glu Val Val Arg 945 950 955 960 Glu Val Wing Val Glu Glu Thru Pro Wing Wing Pro Wing Glu Thr Thr Glu 965 970 975 Thr Pro Wing Thr Pro Wing Thr Pro Pro Wing Val Wing Wing Wing Wing Pro 980 985 990 Wing Thr Gly Gly Pro Arg Pro Asp Asp He Ser Phe Thr Pro Ser Asp 995 1000 1005 Wing Thr Glu Met Leu He Wing He Thr Lys Val Arg Pro Asp Gln 1010 1015 1020 Met Gly Ala Thr Asp Ser He Glu Thr Leu Val Glu Gly Val Ser Ser 1025 1030 1035 1040 Arg Arg Asn Gln Leu Leu Leu Asp Leu Gly Val Glu Phe Gly Leu Gly 1045 1050 1055 Ala He Asp Gly Ala Ala Asp Ala Glu Leu Gly Asp Leu Lys Val Thr 1060 1065 1070 Val Ser Lys Met Wing Lys Gly Tyr Lys Wing Phe Gly Pro Val Leu Ser 1075 1080 1085 Asp Ala Ala Ala Asp Ala Leu Arg Arg Leu Thr Gly Pro Thr Gly Lys 1090 1095 1100 Arg Pro Gly Tyr He Wing Glu Arg Val Thr Gly Thr Glu Leu Gly 1105 1110 1115 1120 Gln Gly Wing Asp His Val Val Wing Glu Val Val He Gly Wing Arg 1125 1130 1135 Glu Gly Ala Ser Leu Arg Gly Gly Asp Leu Ala Ser Leu Ser Pro Ala 1140 1145 1150 Ser Pro Ala Ser Ala Be Asp Leu Asp Ser Leu He Asp Ala Ala Val 1155 1160 1165 Gln Ala Val Ala Ser Arg Arg Gly Val Ala Val Ser Leu Pro Ser Ala 1170 1175 1180 Gly Gly Wing Wing Gly Gly Val Val Asp Ser Wing Wing Leu Gly Glu Phe 1185 1190 1195 1200 Wing Glu Gln Val Thr Gly His Asp Gly Val Leu Wing Gln Wing Wing Arg 1205 1210 1215 Thr He Leu Thr Gln Leu Gly Leu Asp Lys Pro Wing Thr Val Ser Val 1220 1225 1230 Glu Asp Thr Ala Glu Glu Asp Leu Tyr Glu Leu Val Ser Lys Glu Leu 1235 1240 1245 Gly Ser Asp Pro Arg Gln Val Pro Ala Ser Phe Asp Glu Glu Lys 1250 1255 1260 Val Val Leu Leu Asp Asp Arg Wing Be Wing Arg Glu 1265 1270 1275 < 210 > 55 < 211 > 4953 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (4930) < 223 > RXA02582 < 400 > 55 tggatgticta -ttctcctcag c, etcgttttg gttgaggcgg ata.gttttaa tattttttta 60 agtttaaigtt 1gtaategage tgaaaggctg aggcctcaat atg gaa cag age caa 115 Met Glu Gln Ser Gln 1 5 tcg tcg gat cag aag atg acc gtt gaa cag gtt cgc acc tgg etc cgt 163 Be Ser Asp Gln Lys Met Thr Val Glu Gln Val Arg Thr Leu Arg 10 15 20 gat tgg gtt gtc cgc acc acg ggt att ccg gtg gag gaa gtt acg gat 211 Asp Val Val Arg Thr Thr Gly He Pro Val Val Glu Val Thr Asp 25 30 35 gac aag gca atg gag acc ttt ggc ctt tcc tet cgc gat gtt gtt gtg 259 JQ Asp Lys Wing Met Glu Thr Phe Gly Leu Ser Ser Arg Asp Val Val Val 40 45 50 ttg tet ggt gag ctg gaa aac ctg ctg gac acc tcc ttg gat gcc acc 307 Leu Ser Gly Glu Leu Glu Asn Leu Leu Asp Thr Ser Leu Asp Wing Thr 55 60 65 ate gct tat gag tac cca acg ate cgt agt ttg gcg cag cgc ctt gtt 355 He Wing Tyr Glu Tyr Pro Thr He Arg Ser Leu Wing Gln Arg Leu Val 70 75 80 85 gag ggc gag ect cgt cgt gca cat acc cag cgt gaa ttg aat ttc tcc 403 Glu Gly Glu Pro Arg Arg Wing His Thr Gln Arg Glu Leu Asn Phe Ser 90 95 100 gcg gtg age gat tcc cca ggt tcc falls gat att gcg gtt gtc ggt atg 451 15 Wing Val Ser Asp Ser Pro Gly Ser His Asp He Wing Val Val Gly Met 105 110 115 gct gcg cgt tac cca ggc gct gag age ctg gag gat atg tgg aag cta 499 Wing Wing Arg Tyr Pro Gly Wing Glu Ser Leu Glu Asp Met Lys Leu 120 125 130 etc gtc gag ggc cgt gac ggt ate tcg gat cta gcc att ggc cgt tgg 547 Leu Val Glu Gly Arg Asp Gly He Ser Asp Leu Pro He Gly Arg 135 140 145 tet gag tat gca ggc gat gag gtt atg tet cgg aag atg gaa gag ttt 595 Ser Glu Tyr Wing Gly Asp Glu Val Met Ser Arg Lys Met Glu Glu Phe 150 155 160 165 tet acc ate ggt ggc tac ctg tea gat ate tet age ttt gat gcg gag 643 j0 Be Thr He Gly Gly Tyr Leu Be Asp Be Ser Be Phe Asp Wing Glu 170 175 180 ttc ttt ggt ctg tet ccg etc gag gcc gcc aac atg gat ect cag cag 691 Phe Phe Gly Leu Ser Pro Leu Glu Wing Wing Asn Met Asp Pro Gln Gln 185 190 195 cgt att ttg ctg gag cta acg tgg gag gct ttg gag tac gct cgc ate 739 Arg He Leu Leu Glu Leu Thr Glu Wing Leu Glu Tyr Wing Arg He 200 205 210 gca cca aac act ttg cgt ggc gaa gcc gtg ggc gtg ttc ata ggt tcc 787 Wing Pro Asn Thr Leu Arg Gly Glu Wing Val Gly Val Phe He Gly Ser 215 220 225 tcc aac aac aac gc aac gc a cc g atc gc cc gca gaa gca 835 , 5 Ser Asn Asn Asp Tyr Gly Met Met Wing Ala Wing Asp Pro Wing Glu Wing 230 235 240 245 cat ect tat gcg ctg act ggt act tet agt gcg att gtc gct aac cgc 883 His Pro Tyr Ala Leu Thr Gly Thr Ser Wing He Val Ala Asn Arg 250 255 260 att aac tac gct ttc gat ttc cgc ggt ect tcc gtc aac gtg gat acc 931 He Asn Tyr Ala Phe Asp Phe Arg Gly Pro Ser Val Asn Val Asp Thr 265 270 275 gca tgt tet tet tet ctg gta gcg gtt falls cag gct gct cgt gcg ctg 979 Wing Cys Being Ser Val Leu Val Wing Gln Wing Val Arg Wing Leu 280 285 290 cgt aat ggc gaa gcg gat fall gct ate gct ggt gga gtg aac att ttg 1027 Arg Asn Gly Glu Wing Asp His Wing He Wing Wing Gly Gly Val Asn He Leu 295 300 305 gca tet cca ttt gtc here act gca ttc gct gag etc ggt gtg ate age 1075 Wing Ser Pro Phe Val Thr Thr Wing Phe Wing Glu Leu Gly Val He Ser 310 315 320 325 cca acc ggc aag ate drops gca ttc tet gat gat gcc gat gtc ttc gtg 1123 Pro Thr Gly Lys He His Wing Phe Ser Asp Asp Wing Asp Gly Phe Val 330 335 340 cgt tcc gac ggc gcc gga gtc gtt gtg ctg aag cgc gtg gat gac gca 1171 Ar9 Ser Asp Gly Wing Gly Val Val Val Leu Lys Arg Val Asp Asp Wing 345 350 355 ate cgc gac ggc gac aag ate ate ggt gtg ate aag ggt tet gca gtg 1219 He Arg Asp Gly Asp Lys He He Gly Val He Lys Gly Ser Wing Val 360 365 370 aac tcc gat ggt falls tcc aac gga ctg acc gct cca aac ect gac gca 1267 Asn Ser Asp Gly His Ser Asn Gly Leu Thr Ala Pro Asn Pro Asp Wing 375 380 385 cag gtt gat gtg ctg cag cgt gca tat gtt gac gct cag gtt gat ccc 1315 Gln Val Asp Val Leu Gln Arg Wing Tyr Val Asp Wing Gln Val Asp Pro 390 395 400 405 action acc gtg gat tac gtt gag gct fall ggc acc ggc acc ate ctg ggt 1363 thr Thr Val Asp Tyr Val Glu Wing His Gly Thr Gly Thr He Leu Gly 410 415 420 gac ccc att gaa gca act gcc ctg ggt gct gtt ttg ggc tat ggc cgt 1411 Asp Pro He Glu Ala Thr Ala Leu Gly Ala Val Leu Gly Tyr Gly Arg 425 430 435 gac gca tcc acc acca ctc cg ggc tet gca tc aac aac tc gcc 1459 Asp Wing Ser Thr Pro Thr Leu Leu Gly Ser Wing Lys Ser Asn Phe Gly 440 445 450 drops act g ag tea gct gcg ggt att gca ggt gtc ate aag gtg ctg ctt 1507 His Thr Glu Be Wing Wing Gly He Wing Gly Val He Lys Val Leu Leu 455 460 465 gct ttg cag aac aag act ctg cca cca acc gtg aac ttt gca ggt cca 1555 Wing Leu Gln Asn Lys Thr Leu Pro Pro Thr Val Asn Phe Wing Gly Pro 470 475 480 485 aac cgc tac ate gat ttc gat gct gag cgt ttg gaa gtt gtg gaa gat 1603 Asn Arg Tyr He Asp Phe Asp Wing Glu Arg Leu Glu Val Val Glu Asp 490 495 500 cca cgt gaa tgg ccg gaa tac aac ggt falls gca gta gct ggt gtg tet 1651 Pro Arg Glu Trp Pro Glu Tyr Asn Gly His Wing Val Wing Gly Val Ser 505 510 515 gcg ttc ggg ttc ggt gga acc aac gcg falls gtg gtg ate tet gag tac 1699 Wing Phe Gly Phe Gly Gly Thr Asn Wing His Val Val He Ser Glu Tyr 520 525 530 aac gca gaa gac tac gaa acc cgt gcc ccg aag gac gcg ttg ctt ect 1747 Asn Ala Glu Asp Tyr Glu Thr Arg Ala Pro Lys Glu Ala Leu Leu Pro ^ Ü ^^ l 535 540 545 gac cag gtt gcc ctg ccg gtg tet ggt falls ctg cca tcc agg cgt 1795 Asp Gln Gln Val Ala Leu Pro Val Ser Gly His Leu Pro Ser Arg Arg 550 555 560 565 cga ca gca gct gct gct gac ttg gcg gac ttc tgc gag ggc cgc aaa gat 1843 Arg Gln Wing Wing Wing Asp Leu Wing Asp Phe Leu Glu Gly Arg Lys Asp 570 575 580 tgc gac cta acc cca gta gcc cgc gcg ctg gca ggc cgc aat cat ggc 1891 Cys Asp Leu Thr Pro Val Ala Arg Ala Leu Ala Gly Arg Asn His Gly 585 590 595 cgc tcc cgc gca gtc gtg ctt gca age act ate gag gaa gcc gta aag 1939 Arg Ser Arg Ala Val Val Leu Ala Ser Thr He Glu Glu Ala Val Lys 600 605 610 cgc ctg cgc cag gtc gca gaa ggc aag gtc age gtc ggt ate tcc gca 1987 Arg Leu Arg Gln Val Wing Glu Gly Lys Val Ser Val Gly He Ser Wing 615 620 625 gct gat ccc gcg gcc aac ggt ect gtg ttt gtg tac tc ggt gtc ttc 2035 Wing Asp Ser Pro Wing Wing Asn Gly Pro Val Phe Val Tyr Ser Gly Phe 630 635 640 645 gga tcc cgc cgc falls etc atg ate aag gaa ttg tgc tea att tcg cca 2083 10 Gly Ser Gln His Arg Leu Met He Lys Glu Leu Cys Ser He Ser Pro 650 655 660 cag tcc cgc gag cgc ate gaa gag etc gat gaa atg gtt aag ttc gag 2131 • Gln Phe Arg Glu Arg He Glu Glu Leu Asp Glu Met Val Lys Phe Glu 665 670 675 tcc ggc tgg tcc ate atg aaa ctt gtt ttg gat gat gag caa act tac 2179 Ser Gly Trp Ser Met Met Lys Leu Val Leu Asp Asp Glu Gln Thr Tyr 680 685 690 gac acc gag acc gcg cag gtt gtg ate acc gca ate cag ate gca ctg 2227 Asp Thr Glu Thr Ala Gln Val Val He Thr Ala He Gln He Ala Leu 695 700 705 act gac ctg ttg gca age ttc ggt gta aag cca gct gcc gtc atg ggc 2275 15 Thr Asp Leu Leu Wing Being Phe Gly Val Lys Pro Wing Wing Val Met Gly 710 715 720 725 atg tcg atg ggt gag ate gct gcc gct tac gct gcc ggt gga etc age 2323 Met Ser Met Gly Glu He Ala Wing Wing Tyr Wing Ala Gly Gly Leu Ser 730 735 740 gac cgc gat acc atg etc att gcc age drops cgt tcc cgc cta atg ggc 2371 Asp Arg Asp Thr Met Leu He Wing His Arg Ser Arg Leu Met Gly 745 750 755 gag ggc gag aag tcc ctg gct gag gat cag ctg ggt gcc atg gct gtg 2419 Glu Gly Glu Lys Ser Leu Wing Glu Asp Gln Leu Gly Wing Met Wing Val 760 765 770 gtg gaa tcc gcc gcg gac ctg gat aag ttc ate gaa gaa aac ect 2467 20 Val Glu Phe Ala Ala Ala Asp Leu Asp Lys Phe He Glu Glu Asn Pro 775 780 785 gag tac aag ggc att gag ect gct tat gca ggc cca ggc atg act 2515 Glu Tyr Lys Gly He Glu Pro Wing Val Tyr Wing Gly Pro Gly Met Thr 790 795 800 805 acc gtg ggt gga ect cgc gac gcc gtg gtt cag ttc gta gag aag ctg 2563 Thr Val Gly Gly Pro Arg Asp Ala Val Val Gln Phe Val Glu Lys Leu 810 815 820 gaa tet gaa gac aag ttt gcc cgc ctg etc aac gtc aag ggc gct gcc 2611 Glu Ser Glu Asp Lys Phe Wing Arg Leu Leu Asn Val Lys Gly Wing Gly 825 830 835 falls acc tet gct gtg gaa cca ctt ctt ggt gag etc gct ggc gaa ate 2659 25 His Thr Ser Wing Val Glu Pro Leu Leu Gly Glu Leu Wing Gly Glu He *? ti 840 845 850 gct ggc ate gag cca ctt cgc cg gg cg cg ttg ttc age tet gtc 2707 Wing Gly He Glu Pro Leu Pro Leu Gln He Pro Leu Phe Ser Ser Val 855 860 865 gat cag ggt gtt acc tac cca gtt gga gca gtg gtc falls gac gcc gat 2755 Asp Gln Gly Val Thr Val Tyr Pro Val Gly Wing Val Val Asp Wing Asp 870 875 880 885 tac atg etc cgc tgt acc cgc cag tcc gtg tac tcc cag gac tcc acc 2803 Tyr Met Leu Arg Cys Thr Arg Gln Ser Val Tyr Phe Gln Asp Ser Thr • 890 895 900 gaa gct gca ttc gct gca ggc falls aac acc ttg gtg gaa att tcc ccg 2851 Glu Ala Ala Phe Ala Ala Gly His Asn Thr Leu Val Glu He Ser Pro 905 910 915 aac cca gtt gca etc atg ggc atg atg aac acc gcg ttc acc gtg ggc 2899 asn pro val ala leu met gly met met asn thr ala phe thr val gly 920 925 930 aag ect gat gca cag ctg ctg ttc age ctg aag cga aaa gtc cca gag 2947 Lys Pro Asp Wing Gln Leu Leu Phe Ser Leu Lys Arg Lys Val Pro Glu 935 940 945 gca gaa tcc etc cgc gac ctt ctg gcg aag ctg tac gtc aac ggc gca 2995 10 Wing Glu Ser Leu Arg Asp Leu Leu Wing Lys Leu Tyr Val Asn Gly Wing 950 955 960 965 aac gtt gat ttc tcc gcg ctg tac ggc gaa ggt gaa acc ate gat ccg 3043 Asn Val Asp Phe Ser Ala Leu Tyr Gly Glu Gly Glu Thr He Asp Pro • 970 975 980 cca falls a tgg aag falls cgc ttc tgg act tca gca cgc cca 3091 Pro His He Thr Trp Lys His Gln Arg Phe Trp Thr Ser Wing Arg Pro 985 990 995 tcc tet ggc gcai tcc ctg gat ctg ccg ggc ttc cgc gtg aat ctg cca 3139 Ser Ser Gly Alai Ser Leu Asp Leu Pro Gly Phe Arg Val Asn Leu Pro 100C) 1005 1010 aac aac act; gtci gcg ttt tcc acc gca gcc gaa ctg gca cca tcc gca 3187 15 Asn Asn Thi: Val. Wing Phe Ser Thr Wing Wing Glu Leu Wing Pro Wing 1015 1020 1025 gtg gca ate: ate [gaa gca gcc gcc atg gct gtc acc cca ggt tcc tcc 3235 Val Ala Hei Met: Glu Wing Wing Wing Met Wing Val Thr Pro Gly Ser Ser 1030 1035 1040 104 gtc gac gca gtg gac gag cgc gac atg ctg cca cca age ggc gaa ate 3283 Val Asp Ala Val Asp Glu Arg Asp Met Leu Pro Pro Ser Gly Glu He 1050 1055 1060 acc acc gtg act cgc tcc tg ggc ggt ttg age ctg tcc gta tac 3331 Thr Thr He Val Thr Arg Ser Leu Gly Gly Leu Ser Leu Ser Val Tyr 1065 1070 1075 aag att gag gga acc acc age act ctt gtc gcc gaa ggt ttc gca gcc 3379 20 L Lyyss He Glu Gly Thr Thr Ser Thr Leu Val Wing Glu Gly Phe Wing Wing 1080 1085 1090 aaaacc ccccaa gga ttc gcc gca gca tet tcc tcc gac ggt cca gcc tac gac 3427 AAssnn PPrroo Gly Phe Wing Wing Being Ser Phe Asp Gly Pro Gly Tyr Asp 1095 1100 1105 ggggaa ttttce z aaaacc: aacccc; ggaatt tac age gac cag cca gac ect cgc tcc gac ctg 3475 Gly PPhhees AAssni TThhr]: AAsspp Tyr Ser Asp Gln Pro Asp Pro Arg As Asp Leu 1110 1115 1120 1125 ect ttg gac ate gaa gca gtc cgc tgg gac cca gcg acc gaa acc gtc 3523 Pro Leu Asp He Glu Wing Val Arg Trp Asp Pro Wing Thr Glu Thr Val 1130 1135 1140 gaa gag cgc atg cgc gcc ate gtc tcc gaa gca atg ggc tac gac gtg 3571 25 Glu Glu Arg Met Arg Wing He Val Ser Glu Wing Met Gly Tyr Asp Val 1145 1150 1155 gat gac etc cca cgc gaa etc cca ctg att gac etc ggc etc gac tcc 3619 Asp Asp Leu Pro Arg Glu Leu Pro Leu He Asp Leu Gly Leu Asp Ser 1160 1165 1170 etc atg ggc atg cgc ate aaa aac cgc ate gaa aat gac tcc cag ate 3667 Leu Met Gly Met Arg He Lys Asn Arg He Glu Asn Asp Phe Gln He 1175 1180 1185 cca cca etc cag gtc ca gcg etc cgc gat gca tcc gtc gct gac gtg 3715 • Pro Pro Leu Gln Val Gln Ala Leu Arg Asp Ala Ser Val Ala Asp Val 1190 1195 1200 1205 gta ate atg gtg gaa aac atg gtc gct ggc cgc tcc tet gag acg ctt 3763 Val He Met Val Glu Asn Met Val Wing Gly Arg Ser Be Glu Thr Leu 1210 1215 1220 gtc gac gcc acc ccg cag gtg cca gct gag gca gca ggg gag gct ca 3811 Val Asp Ala Thr Pro Gln Val Pro Ala Glu Ala Wing Gly Glu Wing Gln 1225 1230 1235 gct gct gag tet tet gct tcg ggc gag gac gtg cag ggc gtt ggc gtt 3859 Wing Wing Glu Being Ser Wing Gly Glu Asp Val Gln Gly Val Gly Val 1240 1245 1250 gca ccg cga gat gcg tcg gaa cgc atg gtc ttt ggt act tgg gca ggc 3907 10 Wing Pro Arg Asp Wing Ser Glu Arg Met Val Phe Gly Thr Trp Wing Gly 1255 1260 1265 ctg act ggc gct gcg gca gct ggc gtg acc age aag ttg cca cag ate 3955 • Leu Thr Gly Wing Wing Wing Wing Gly Val Thr Ser Lys Leu Pro Gln He 1270 1275 1280 1285 gat gtc gat act gca acc gca att gcc gag cgc etc acc gag cgt tcc 4003 Asp Val Asp Thr Ala Thr Ala He Wing Glu Arg Leu Thr Glu Arg Ser 1290 1295 1300 gga att gaa ate age act gaa cag gtg ttg gct gca gaa acc etc gaa 4051 Gly He Glu He Ser Thr Glu Gln Val Leu Ala Wing Glu Thr Leu Glu 1305 1310 1315 cca ctg tet gac ctg gtg cgt gaa ggc etc gaa act gaa gtt cag ggc 4099 15 Pro Leu Ser Asp Leu Val Arg Glu Gly Leu Glu Thr Glu Val Gln Gly 1320 1325 1330 aac att cgt gtg ctg cgt gga cgt gca gaa ggc tcc acc aag ect gca 4147 Asn He Arg Val Leu Arg Gly Arg Ala Glu Gly Ser Thr Lys Pro Wing 1335 1340 1345 gtg ttc atg ttc drops cca gct ggc ggt tet tcc gtg gtc tac cac cca 4195 Val Phe Met Phe His Pro Wing Gly Gly Ser Val Val Tyr Gln Pro 1350 1355 1360 1365 tc atg cgt cgt ctg ect gaa gat gtc ect gtc tat ggc gtt gag cgt 4243 Leu Met Arg Arg Leu Pro Glu Asp Val Pro Val Tyr Gly Val Glu Arg 1370 1375 1380 ctg gaa ggc gat etc gct gac cgc gcg gca gca tat gtt gat gac ate 4291 20 Leu Glu Gly Asp Leu Wing Asp Arg Wing Wing Tyr Val Asp Asp He 1385 1390 1395 aag aac tac tcc gcc tcc cca gta gtt ttg ggt ggc tgg age ttc 4339 Lys Lys Tyr Ser Asp Gly Phe Pro Val Val Leu Gly Gly Trp Ser Phe 1400 1405 1410 ggc ggt gcc gtt gcc ttc gag gtt gcc falls ca gt ctg gtt gcc tcc gat 4387 Gly Gly Wing Val Wing Phe Glu Val Wing His Gln Leu Val Gly Ser Asp 1415 1420 1425 gtt gag gta gct gtg gcg gtg ttg ctg gat act gtg cag ect tea aac 4435 Val Glu Val Wing Thr Val Wing Leu Leu Asp Thr Val Gln Pro "Ser Asn 1430 1435 1440 1445 cca gca cca gat acc gct gag gaa act cgt gca cgc tgg act cgc tac 4483 25 Pro Wing Pro Asp Thr Wing Glu Glu Thr Arg Wing Arg Trp Thr Arg Tyr 1450 1455 1460 gcg gac ttc gcc aag aag g ect gc gc ctt gat ttc gag gta ect ttt 4531 Wing Asp Phe Wing Lys Lys Thr Tyr Gly Leu Asp Phe Glu Val Pro Phe 1465 1470 1475 gaa ate ttg gac acc ate ggt gaa gaga gga atg ctg tcc atg atg acc 4579 Glu He Leu Asp Thr He Gly Glu Asp Gly Met Leu Ser Met Met Thr 1480 1485 1490 gac ttc ctg gcc aac acc gac gcc tcc gag falls gga ttg tcc gca ggt 4627 Asp Phe Leu Wing Asn Thr Asp Wing Ser Glu His Gly Leu Wing Wing Gly 1495 1500 1505 gtg ctt gaa falls cag cgc gct tet ttt gtg gac aac cgc ate ctg gct 4675 Val Leu Glu His Gln Arg Ala Ser Phe Val Asp Asn Arg He Leu Wing 1510 1515 1520 1525 aaa ctt aat ttt gca gac tgg gcc aac gtt gaa gcc ect qtc ate ctg 4723 Lys Leu Asn Phe Wing Asp Trp Wing Asn Val Glu Wing Pro Val He Leu 1530 1535 1540 tcc cgc gcg gaa cgc atg cat gat gga gct ate gaa ctt gaa cca aac 4771 phe arg ala glu arg met his asp gly ala he glu leu glu pro asn 1545 1550 1555 tat gcc aa g att gat caá gat gga gga tgg tcc gga att gtc aac gat 4819 10 Tyr Wing Lys He Asp Gln Asp Gly Gly Trp Ser Gly He Val Asn Asp 1560 1565 1570 ttg gaa att gtt cag ctg aat ggt gac drops ctg gca gtt gtc gat gaa 4867 • Leu Glu He Val Gln Leu Asn Gly Asp His Leu Wing Val Val Asp Glu 1575 1580 1585 cca gaa ate ggc here gtc gga gct cat ttg agt cgc cgc att gat gag 4915 Pro Glu He Gly Thr Val Gly Ala His Leu Ser Arg Arg He Asp Glu 1590 1595 1600 1605 att tet cgg aag aat tagtaacgga gagctgacgg aag 4953 He Ser Arg Lys Asn 1610 15 < 210 > 56 < 211 > 1610 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 56 Met Glu Gln Ser Gln Ser As Asp Gln Lys Met Thr Val Glu Gln Val 1 5 10 15 • Arg Thr Trp Leu Arg Asp Trp Val Val Arg Thr Thr Gly He Pro Val 20 25 30 Glu Glu Val Thr Asp Asp Lys Ala Met Glu Thr Phe Gly Leu Ser Ser 35 40 45 20 Arg Asp Val Val Val Leu Ser Gly Glu Leu Glu Asn Leu Leu Asp Thr 50 55 60 Ser Leu Asp Wing Thr He Wing Tyr Glu Tyr Pro Thr He Arg Ser Leu 65 70 75 80 Wing Gln Arg Leu Val Glu Gly Glu Pro Arg Arg Wing His Thr Gln Arg 85 90 95 Glu Leu Asn Phe Ser Wing Val Ser Asp Ser Pro Gly Ser His Asp He 100 105 110 Ala Val Val Gly Met Ala Ala Arg Tyr Pro Gly Ala Glu Ser Leu Glu 115 120 125 Asp Met Trp Lys Leu Leu Val Glu Gly Arg Asp Gly He Ser Asp Leu 130 135 140 25 Pro He Gly Arg Trp Ser Glu Tyr Ala Gly Asp Glu Val Met Ser Arg 145 150 155 160 Lys Met Glu Glu Phe Ser Thr He Gly Gly Tyr Leu Ser Asp He Ser 165 170 175 Ser Phe Asp Wing Glu Phe Phe Gly Leu Ser Pro Leu Glu Wing Wing Asn 180 185 190 Met Asp Pro Gln Gln Arg He Leu Leu Glu Leu Thr Trp Glu Wing Leu 195 200 205 Glu Tyr Ala Arg He Ala Pro Asn Thr Leu Arg Gly Glu Wing Val Gly 210 215 220 Val Phe He Gly Ser Ser Asn Asn Asp Tyr Gly Met Met He Ala Wing 225 230 235 240 Asp Pro Wing Glu Wing His Pro Tyr Wing Leu Thr Gly Thr Ser Be Wing 245 250 255 He Val Wing Asn Arg He Asn Tyr Wing Phe Asp Phe Arg Gly Pro Ser 260 265 270 Val Asn Val Asp Thr Wing Cys Ser Ser Leu Val Wing Val His Gln 275 280 285 Wing Val Arg Ala Leu Arg Asn Gly Glu Ala Asp His Ala He Ala Gly 290 295 300 Gly Val Asn He Leu Ala Ser Pro Phe Val Thr Thr Ala Phe Ala Glu 305 310 315 320 Leu Gly Val He Ser Pro Thr Gly Lys He His Ala Phe Be Asp Asp 325 330 335 Wing Asp Gly Phe Val Arg Ser Asp Gly Wing Gly Val Val Val Leu Lys 340 345 350 Arg Val Asp Asp Wing He Arg Asp Gly Asp Lys He He Gly Val He 355 360 365 Lys Gly Ser Wing Val Asn Being Asp Gly His Being Asn Gly Leu Thr Wing 370 375 380 Pro Asn Pro Asp Wing Gln Val Asp Val Leu Gln Arg Wing Tyr Val Asp 385 390 395 400 Wing Gln Val Asp Pro Thr Thr Val Asp Tyr Val Glu Wing His Gly Thr 405 410 415 Gly Thr He Leu Gly Asp Pro He Glu Wing Thr Wing Leu Gly Wing Val 420 425 430 Leu Gly Tyr Gly Arg Asp Wing Ser Thr Pro Thr Leu Leu Gly Ser Wing 435 440 445 Lys Ser Asn Phe Gly His Thr Glu Ser Wing Wing Gly Wing Wing Gly Val 450 455 460 He Lys Val Leu Leu Wing Leu Gln Asn Lys Thr Leu Pro Pro Thr Val 465 470 475 480 Asn Phe Wing Gly Pro Asn Arg Tyr He Asp Phe Asp Wing Glu Arg Leu 485 490 495 Glu Val Val Glu Asp Pro Arg Glu Trp Pro Glu Tyr Asn Gly His Wing 500 505 510 Val Wing Gly Val Ser Wing Phe Gly Phe Gly Gly Thr Asn Wing His Val 515 520 525 Val He Ser Glu Tyr Asn Wing Glu Asp Tyr Glu Thr Arg Ala Pro Lys 530 535 540 Glu Ala Leu Leu Pro Asp Gln Gln Val Ala Leu Pro Val Ser Gly His 545 550 555 560 Leu Pro Ser Arg Arg Arg Gln Ala Ala Ala Asp Leu Ala Asp Phe Leu 565 570 575 Glu Gly Arg Lys Asp Cys Asp Leu Thr Pro Val Wing Arg Wing Leu Wing 580 585 590 Gly Arg Asn His Gly Arg Ser Arg Wing Val Val Leu Wing Ser Thr He 595 600 605 _ > ^ HW Glu Glu Wing Val Lys Arg Leu Arg Gln Val Wing Glu Gly Lys Val Ser 610 615 620 Val Gly He Ser Wing Wing Asp Ser Pro Wing Wing Asn Gly Pro Val Phe 625 630 635 640 Val Tyr Ser Gly Phe Gly Ser Gln His Arg Leu Met He Lys Glu Leu 645 650 655 Cys Ser He Ser Pro Gln Phe Arg Glu Arg He Glu Glu Leu Asp Glu 660 665 670 Met Val Lys Phe Glu Ser Gly Trp Ser Met Met Lys Leu Val Leu Asp 675 680 685 Asp Glu Gln Thr Tyr Asp Thr Glu Thr Wing Gln Val Val He Thr Wing 690 695 700 He Gln He Wing Leu Thr Asp Leu Leu Wing Being Phe Gly Val Lys Pro 705 710 715 720 Wing Wing Val Met Gly Met Ser Met Gly Glu He Ala Wing Ala Tyr Ala 725 730 735 Ala Gly Gly Leu Ser Asp Arg Asp Thr Met Leu He Ala Ser His Arg 740 745 750 Ser Arg Leu Met Gly Glu Glu Glu Lys Ser Leu Ala Glu Asp Gln Leu 755 760 765 Gly Ala Met Ala Val Val Glu Phe Wing Wing Wing Asp Leu Asp Lys Phe 10 770 775 780 He Glu Glu Asn Pro Glu Tyr Lys Gly He Glu Pro Wing Val Tyr Wing • 785 790 795 800 Gly Pro Gly Met Thr Thr Val Gly Gly Pro Arg Asp Wing Val Val Gln 805 810 815 Phe Val Glu Lys Leu Glu Ser Glu Asp Lys Phe Wing Arg Leu Leu Asn 820 825 830 Val Lys Gly Wing Gly His Thr Be Wing Val Glu Pro Leu Leu Gly Glu 835 840 845 Leu Wing Gly Glu He Wing Gly He Glu Pro Leu Pro Leu Gln He Pro 850 855 860 15 Leu Phe Ser Val Val Glp Val Val Tyr Pro Val Gly Wing Val Val 865 870 875 880 Val His Asp Wing Asp Tyr Met Leu Arg Cys Thr Arg Gln Ser Val Tyr 885 890 895 Phe Gln Asp Ser Thr Glu Wing Wing Phe Wing Wing Gly His Asn Thr Leu 900 905 910 Val Glu He Ser Pro Pro Asn Pro Val Wing Leu Met Gly Met Met Asn Thr 915 920 925 Wing Phe Thr Val Gly Lys Pro Asp Wing Gln Leu Leu Phe Ser Leu Lys 930 935 940 Arg Lys Val Pro Glu Wing Glu Ser Leu Arg Asp Leu Leu Wing Lys Leu 945 950 955 960 20 Tyr Val Asn Gly Wing Asn Val Asp Phe Be Wing Leu Tyr Gly Glu Gly 965 970 975 Glu Thr He Asp Pro Pro His He Thr Trp Lys His Gln Arg Phe Trp 980 985 990 Thr Ser Wing Arg Pro Ser Ser Gly Ala Ser Leu Asp Leu Pro Gly Phe 995 1000 1005 Arg Val Asn Leu Pro Asn Asn Thr Val Wing Phe Ser Thr Wing Wing Glu 1010 1015 1020 Leu Wing Pro Wing Wing Val Wing He Met Glu Wing Wing Wing Met Wing Val 1025 1030 1035 1040 Thr Pro Gly Ser Val Asp Ala Val Asp Glu Arg Asp Met Leu Pro 1045 1050 1055 25 Pro Ser Gly Glu He Thr Thr He Val Thr Arg Ser Leu Gly Gly Leu 1060 1065 1070 Ser Leu Ser Val Tyr Lys He Glu Gly Thr Thr Ser Thr Leu Val Wing 1075 1080 1085 Glu Gly Phe Wing Wing Asn Pro Gly Phe Wing Wing Wing Being Ser Phe Asp 1090 1095 1100 Gly Pro Gly Tyr Asp Gly Phe Asn Thr Asp Tyr Ser Asp Gln Pro Asp 1105 1110 1115 1120 Pro Arg Ser Asp Leu Pro Leu Asp He Glu Wing Val Arg Trp Asp Pro 1125 1130 1135 Wing Thr Glu Thr Val Glu Glu Arg Met Arg Wing He Val Ser Glu Wing 1140 1145 1150 Met Gly Tyr Asp Val Asp Asp Leu Pro Arg Glu Leu Pro Leu He Asp 1155 1160 1165 Leu Gly Leu Asp Ser Leu Met Gly Met Arg He Lys Asn Arg He Glu 1170 1175 1180 Asn Asp Phe Gln He Pro Pro Leu Gln Val Gln Wing Leu Arg Asp Wing 1185 1190 1195 1200 Ser Val Wing Asp Val Val He Met Val Glu Asn Met Val Wing Gly Arg 1205 1210 1215 Ser Ser Glu Thr Leu Val Asp Wing Thr Pro Gln Val Pro Wing Glu Wing 1220 1225 1230 Wing Gly Glu Wing Gln Wing Wing Glu Being Ser Wing Gly Glu Asp Val 1235 1240 1245 Gln Gly Val Gly Val Wing Pro Arg Asp Wing Ser Glu Arg Met Val Phe 1250 1255 1260 Gly Thr Trp Wing Gly Leu Thr Gly Wing Wing Wing Wing Gly Val Thr Ser 1265 1270 1275 1280 Lys Leu Pro Gln He Asp Val Asp Thr Wing Thr Wing Wing Glu Arg 1285 1290 1295 1295 Leu Thr Glu Arg Ser Gly He Glu He Be Thr Glu Gln Val Leu Wing 1300 1305 1310 Wing Glu Thr Leu Glu Pro Leu Ser Asp Leu Val Arg Glu Glu Leu Glu 1315 1320 1325 Thr Glu Val Gln Gly Asn He Arg Val Leu Arg Gly Arg Wing Glu Gly 1330 1335 1340 Ser Thr Lys Pro Wing Val Phe Met Phe His Pro Wing Gly Gly Ser Ser 1345 1350 1355 1360 Val Val Tyr Gln Pro Leu Met Arg Arg Leu Pro Glu Asp Val Pro Val 1365 1370 1375 Tyr Gly Val Glu Arg Leu Glu Gly Asp Leu Wing Asp Arg Wing Wing 1380 1385 1390 Tyr Val Asp Asp He Lys Lys Tyr Ser Asp Gly Phe Pro Val Val Leu 1395 1400 1405 Gly Gly Trp Ser Phe Gly Gly Wing Val Wing Phe Glu Val Wing His Gln 1410 1415 1420 Leu Val Gly As Asp Val Glu Val Wing Thr Val Wing Leu Leu Asp Thr 1425 1430 1435 1440 Val Gln Pro Ser Asn Pro Wing Pro Asp Thr Wing Glu Glu Thr Arg Wing 1445 1450 1455 Arg Trp Thr Arg Tyr Wing Asp Phe Wing Lys Lys Thr Tyr Gly Leu Asp 1460 1465 1470 Phe Glu Val Pro Phe Glu He Leu Asp Thr He Gly Glu Asp Gly Met 1475 1480 1485 Leu Ser Met Met Thr Asp Phe Leu Wing Asn Thr Asp Wing Ser Glu His 1490 1495 1500 Gly Leu Ser Ala Gly Val Leu Glu His Gln Arg Ala Ser Phe Val Asp 1505 1510 1515 1520 ???.? 4 Asn Arg He Leu Wing Lys Leu Asn Phe Wing Asp Trp Wing Asn Val Glu 1525 1530 1535 Wing Pro Val He Leu Phe Arg Wing Glu Arg Met His Asp Gly Wing He 1540 1545 1550 Glu Leu Glu Pro Asn Tyr Wing Lys He Asp Gln Asp Gly Gly Trp Ser 1555 1560 1565 Gly He Val Asn Asp Leu Glu He Val Gln Leu Asn Gly Asp His Leu 1570 1575 1580 Wing Val Val Asp Glu Pro Glu He Gly Thr Val Gly Ala His Leu Ser 1585 1590 1595 1600 Arg Arg He Asp Glu He Ser Arg Lys Asn 1605 1610 <; 210 > 57 < 211 > 930 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS 10 < 222 > (101) .. (907) < 223 > RXA02691 • < 400 > 57 ctt, agggctt, atctgttttc cagccittget ttttactagg cgctcctgtc < ecgcttcagt 60 caccaaaacc, acacccctgg ttatgaccaig atcggctaaa atg aac ect atg ect 115 Met Asn Thr Met Pro 1 5 gac cac ccg etc aac cag gac gga ttc ect acc gca tcc aaa ggg gtg 163 Asp Gln Pro Leu Asn Gln Asp Gly Phe Pro Thr Ala Ser Lys Gly Val 10 15 20 gaa ccc gac aac etc ccc gac cgc gtt etc gtg gac ggc ctt aaa cca 211 15 Glu Pro Asp Asn Leu Pro Asp Arg Val Leu Val Asp Gly Leu Lys Pro 25 30 35 aag cat cag cag ctt cgt gaa att ttg gag gaa ate tgc acc acc 259 Lys His Gln Gln Leu Arg Glu He Leu Glu Glu He Cys Thr Thr Gln 40 45 50 ctt cag ect ggg gac atg ctg ect ggt gag cgc ate ctg gaa gaa aag 307 Leu Gln Pro Gly Asp Met Leu Pro Gly Glu Arg He Leu Glu Glu Lys 55 60 65 • tat ggc gtc age cga att acg gtt cgt cgt gcg att ggt gat ctg gtc 355 Tyr Gly Val Ser Arg He Thr Val Arg Arg Wing He Gly Asp Leu Val 70 75 80 85 gcg tcc ggc agg ttg aag cga gct cgc ggc aaa ggt acc ttc gtg gcc 403 20 Wing Being Gly Arg Leu Lys Arg Wing Arg Gly Lys Gly Thr Phe Val Wing 90 95 100 drops tcg ccg ttg att tcc cgc ctg cat ttg gcc tcg ttt tc gca gag 451 His Ser Pro Leu He Ser Arg Leu His Leu Ala Ser Phe Be Wing Glu 105 110 115 atg gcc gcc cag aag cta tcg gct acc agg att ttg agt tet tcc 499 Met Wing Ala Gln Lys Leu Ser Wing Thr Ser Arg He Leu Being Ser 120 125 130 cgc ggt ccc gcc cca gat gat att gct gat ttc ttt ggt acc gat cgc 547 Arg Gly Pro Wing Pro Asp Asp He Wing Asp Phe Phe Gly Thr Asp Arg 135 140 145 gcg gcc cag falls tcg cgc cgc gt cgc ct ct gt gt aga ggt cga cgc 25 Ala Ala Gln His He Thr Leu Arg Arg Leu Arg Phe Gly Asn Gly Arg **, í? A, 150 155 160 165 ccc tat gcc att gac aac ggt tgg tac aac tcc gaa tcc gca ect gac 643 Pro Tyr Ala He Asp Asn Gly Trp Tyr Asn Ser Glu Phe Ala Pro Asp 170 175 180 ctg ctg gaa aat gat gtg tac aac tcc gtg tac tcc ate ctg gac cgc 691 Leu Leu Glu Asn Asp Val Tyr Asn Ser Val Tyr Ser He Leu Asp Arg 185 190 195 gtc tat ggc gtc ccc gtc acc gcc cag acc ggc acg gtc ac acc gcc gtc 739 Val Tyr Gly Val Pro Val Thr Gln Wing Glu Gln Thr Val Thr Wing Val 205 205 210 gca gcc gac gaa gac acc gca cgg ctt ctg gac gtc acc ccc ggc gcc 787 Wing Wing Asp Glu Asp Thr Wing Arg Leu Leu Asp Val Thr Pro Gly Wing 215 220 225 ctc etc ctt cgt ate ctt cg cga cag tea ctt tet ggc gat aag ccc gtg 835 Pro Leu Leu Arg He Leu Arg Gln Ser Leu Ser Gly Asp Lys Pro Val 230 235 240 245 gaa tgg tgc gtt tcc ttg tac cga acc gac cga tat tet tta aaa here 883 Glu Trp Cys Val Ser Leu Tyr Arg Thr Asp Arg Tyr Ser Leu Lys Thr 250 255 260 ttg gtt here cgc tcc gaa gat etc tgacgtgaac ccattttggt ggc 930 10 Leu Val Thr Arg Ser Glu Asp Leu 265 • < 210 > 58 < 211 > 269 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 58 Met Asn Thr Met Pro Asp Gln Pro Leu Asn Gln Asp Gly Phe Pro Thr 1 5 10 15 Wing Ser Lys Gly Val Glu Pro Asp Asn Leu Pro Asp Arg Val Leu Val 15 20 25 30 Asp Gly Leu Lys Pro Lys His Gln Gln Leu Arg Glu He Leu Glu Glu 35 40 45 He Cys Thr Thr Gln Leu Gln Pro Gly Asp Met Leu Pro Gly Glu Arg 50 55 60 He Leu Glu Glu Lys Tyr Gly Val Ser Arg He Thr Val Arg Arg Ala 65 70 75 80 He Gly Asp Leu Val Wing Being Gly Arg Leu Lys Arg Wing Arg Gly Lys • 85 90 95 Gly Thr Phe Val Wing His Ser Pro Leu He Ser Arg Leu His Leu Wing 100 105 110 Ser Phe Ser Ala Glu Met Ala Ala Gln Lys Leu Ser Wing Thr Ser Arg 20 115 120 125 He Leu Being Ser Arg Gly Pro Wing Pro Asp Asp He Wing Asp Phe 130 135 140 Phe Gly Thr Asp Arg Wing Wing Gln His He Thr Leu Arg Arg Leu Arg 145 150 155 160 Phe Gly Asn Gly Arg Pro Tyr Wing He Asp Asn Gly Trp Tyr Asn Ser 165 170 175 Glu Phe Wing Pro Asp Leu Leu Glu Asn Asp Val Tyr Asn Ser Val Tyr 180 185 190 Ser He Leu Asp Arg Val Tyr Gly Val Pro Val Thr Gln Ala Glu Gln 195 20 0 205 Thr Val Thr Ala Val Ala Ala Asp Glu Asp Thr Ala Arg Leu Leu Asp 25 210 215 220 Val Thr Pro Gly Ala Pro Leu Leu Arg He Leu Arg Gln Ser Leu Ser 225 230 235 240 Gly Asp Lys Pro Val Glu Trp Cys Val Ser Leu Tyr Arg Thr Asp Arg 245 250 255 Tyr Ser Leu Lys Thr Leu Val Thr Arg Ser Glu Asp Leu 260 265 < 210 > 59 < 211 > 1968 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1945) < 223 > RXA00880 < 400 > 59 tccatgtggt taaagatatg cctaaagatc tgaccaaaaa cgtgactaaa gacgtgacga 60 cacaagtaca gccaaattaa aggaaaggtt gaatttgacc atg act tea ect aat 115 0 Met Thr Ser Pro Asn 1 5 acc ctg cag gaa tac act gact ect gcc aag tac acc ate gga gaa tet 163 Thr Leu Gln Glu Tyr Thr Glu Pro Wing Lys Tyr Thr He Gly Glu Ser 10 15 20 gaa acc tgc ctg acc gcc ctt cta gat cag att aag act cga ect tac 211 Glu Thr Cys Leu Thr Ala Leu Leu Asp Gln He Lys Thr Arg Pro Tyr 25 30 35 gga gtt ttg ttc age aag ect gcc aac tat gag tgg gtg aat gta act 259 Gly Val Leu Phe Ser Lys Pro Wing Asn Tyr Glu Trp Val Asn Val Thr 40 45 50 gcc aaa gaa ttt cag gac gag gtt ttt gcg gtt gca aaa gga att att 307 5 Wing Lys Glu Phe Gln Asp Glu Val Phe Wing Val Wing Lys Gly He He 55 60 65 tea gtc ggc gg gag cag gg gac cgt gtc gcg ctg ctg tcc aat act 355 Ser Val Gly Val Glu Gln Gly Asp Arg Val Ala Leu Leu Ser Asn Thr 70 75 80 85 cgc tat gag tgg gct gtg ctt gat ttc gct ate tgg gcc gct ggc gca 403 Arg Tyr Glu Trp Wing Val Leu Asp Phe Wing He Trp Wing Wing Gly Wing 90 95 100 gtg age gtg ect ate tac age tcc tet tea ctg tcc ca a att gag tgg 451 Val Ser Val Pro He Tyr Being Being Being Leu Ser Gln He Gl u Trp 105 110 115 ate att gag gat tcc ggc gct gtt ttg gcc att acc gaa acc ect gat 499 Q He He Glu Asp Ser Gly Ala Val Leu Ala He Thr Glu Thr Pro Asp 120 125 130 cat acc gac ttg atg aag aac ctg gtc ate ggt gaa gac gga act cca 547 His Thr Asp Leu Met Lys Asn Leu Val He Gly Glu Asp Gly Thr Pro 135 140 145 gcg att aag ggt tea ect tcc aag ctg cgc cgc att cta gag ate aac 595 Ala He Lys Gly Ser Pro Ser Lys Leu Arg Arg He Leu Glu He Asn 150 155 160 165 tet tcg gcg ttg gag acc ttg aag ttt gag ggc cgc gag ctt tet gat 643 Ser Be Ala Leu Glu Thr Leu Lys Phe Glu Gly Arg Glu Leu Ser Asp 170 175 180 gag ctg gtg tgg gaa cgc att cat gca acc aag gcc gct gac ctg gcg 691 Glu Leu Val Trp Glu Arg He His Wing Thr Lys Wing Wing Asp Leu Wing ^, JÁ ÁA 185 190 195 tet ttg gtg tac acc tet ggc here act ggt agg ccg aag ggc tgc gag 739 Ser Leu Val Tyr Thr Ser Gly Thr Thr Gly Arg Pro Lys Gly Cys Glu 200 205 210 ttg tcc falls tac falls tgg ttg gct gag gtc cga gcg ctg ate acc aat 787 Leu Ser His Tyr His Trp Leu Ala Glu Val Arg Ala Leu He Thr Asn 215 220 225 gac ate gga gcg ate gcg atg cca ggt tea agg ttg etc acc ttc ctt 835 Asp He Gly Wing He Wing Met Pro Gly Ser Arg Leu Leu Thr Phe Leu 230 235 240 245 ect ttg gcg falls gtt ctt gct cgc gca gtg falls ttg gcc ttc gct gtc 883 Pro Leu Ala His Val Leu Ala Arg Ala Val His Leu Ala Phe Ala Val 250 255 260 acc ggt gca acc cag tcc falls tgg tet gat ttc age acc ctt act ttg 931 Thr Gly Ala Thr Gln Ser His Trp Ser Asp Phe Ser Thr Leu Thr Leu 265 270 275 gaa ctg cag cgt tcc cgc ccg aac ctg att ttg ggt gtt cca cgc gtg 979 Glu Leu Gln Arg Ser Arg Pro Asn Leu He Leu Gly Val Pro Arg Val 280 285 290 ttt gaa aag gtc cgc aac gcc gct gct gct act gct gct gac ggt ggc 1027 phe glu lys val arg asn wing wing wing wing asn wing wing asp gly gly 295 300 305 gca ate aag cgc ate atg ttt gag cgt gcc gaa aag gcg gcc att gaa 1075 Wing He Lys Arg He Met Phe Glu Arg Wing Glu Lys Wing Wing He Glu 310 315 320 325 tac tcc atg gct ctt gat act gca gaa ggc cca age aag tcc cag gtt 1123 Tyr Ser Met Wing Leu Asp Thr Wing Glu Gly Pro Se r Lys Ser Gln Val 330 335 340 atg gca cat aaa gcg ttt gac aag ctg gtg tac tcc aag ate cgt gca 1171 Met Ala His Lys Ala Phe Asp Lys Leu Val Tyr Ser Lys He Arg Ala 345 350 355 gct gtc ggt ggc gat gtg cag tac gcc ate acc ggt ggt tea gcg atg 1219 Wing Val Gly Gly Asp Val Gln Tyr Wing He Thr Gly Gly Ser Wing Met 360 365 370 ggg cag gag ctg ctg falls ttc ttc cgc ggt gtg ggc atg acc ate tac 1267 Gly Gln Glu Leu Leu His Phe Phe Arg Gly Val Gly Met Thr He Tyr 375 380 385 gaa ggt tat ggt ctg acg gaa tet gcg gct gct gca gcg gtg gac ttc 1315 Glu Gly Tyr Gly Leu Thr Glu Be Ala Wing Wing Wing Wing Val Asp Phe 390 395 400 405 act gat ca g a g gc a gc gg ggt aag ccg atg ggt ggc atg acc 1363 Thr Asp Gln Lys He Gly Thr Val Gly Lys Pro Met Gly Gly Met Thr 410 415 420 ate aag ate aat gaa gat ggc gaa ate atg cta aaa ggc gag atg ttg 1411 He Lys He Asn Glu Asp Gly Glu He Met Leu Lys Gly Glu Met Leu 425 430 435 ttc cag gga tat tgg aac aac cca gaa gcc here gca gaa gcc etc drops 1459 Phe Gln Gly Tyr Trp Asn Asn Pro Glu Ala Thr Ala Glu Ala Leu His 440 445 450 gac ggt tgg ttc aac acc ggc gat ctg ggt gag ctg ttg gag tet gga 1507 Asp Gly Trp Phe Asn Thr Gly Asp Leu Gly Glu Leu Leu Glu Ser Gly 455 460 465 falls ctg gtg ate acc gga cgt aag aaa gat ctg ate gtg acc gcg ggc 1555 His Leu Val He Thr Gly Arg Lys Lys Asp Leu He Val Thr Wing Gly 470 475 480 485 ggc aag aac gtt tcc cca gga ccc atg gaa gac ate ate cgc gca cae 1603 Gly Lys Asn Val Ser Pro Gly Pro Met Glu A sp He He Arg Ala His 490 495 500 cca ctg gtc age cag gcc atg gtg gtg ggc gat ggt aaa cca ttc gtt 1651 Pro Leu Val Ser Gln Ala Met Val Val Gly Asp Gly Lys Pro Phe Val 505 510 515 ggc ctg ctg gtg acc ttg gat cca gat atg ttg aag cgg tgg aag ctg 1699 Gly Leu Leu Val Thr Leu Asp Pro Asp Met Leu Lys Arg Trp Lys Leu 520 525 530 aac falls aac att gcg gaa tcc cgc acg gtt tet gag att gct act gat 1747 Asn His Asn He Wing Glu Ser Arg Thr Val Ser Glu He Wing Thr Asp 535 540 545 ect gca ctg cgt gcg gaa ate cag gat gc gc aac aac gct aat gcc 1795 Pro Ala Leu Arg Ala Glu He Gln Asp Ala Val Asn Asn Ala Asn Ala 550 555 560 565 acg gtg tet cat tea gag gcg ate aag cgg ttc tac ate ctt gat cgc 1843 Thr Val Ser His Ser Glu Ala He Lys Arg Phe Tyr He Leu Asp Arg 570 575 580 gac ctg acc gag gaa gcc gac gag ctg acc cca acg ctg aag gtc aag 1891 Asp Leu Thr Glu Glu Wing Asp Glu Leu Thr Pro Thr Leu Lys Val Lys 585 590 595 cgc aac gtt gtt gtt cgc cgt tac gca gac gcc ate gac cae ate tac 1939 Arg Asn Val Val Val Arg Arg Tyr Ala Asp Ala He Asp His He Tyr 10 600 605 610 aac cga tgagtaacac agacaa ttt 1968 • Asn Arg 615 < 210 > 60 < 211 > 615 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 60 15 Met Thr Ser Pro Asn Thr Leu Gln Glu Tyr Thr Glu Pro Wing Lys Tyr 1 5 10 15 Thr He Gly Glu Ser Glu Thr Cys Leu Thr Wing Leu Leu Asp Gln He 20 25 30 Lys Thr Arg Pro Tyr Gly Val Leu Phe Ser Lys Pro Wing Asn Tyr Glu 35 40 45 Trp Val Asn Val Thr Wing Lys Glu Phe Gln Asp Glu Val Phe Wing Val 50 55 60 • Wing Lys Gly He He Ser Val Gly Val Glu Gln Gly Asp Arg Val Wing 65 70 75 80 Leu Leu Ser Asn Thr Arg Tyr Glu Trp Wing Val Leu Asp Phe Wing He 85 90 95 20 Trp Wing Wing Gly Wing Val Ser Val Pro He Tyr Ser Ser Ser Leu 100 105 110 Ser Gln He Glu Trp He He Glu Asp Ser Gly Wing Val Leu Wing He 115 120 125 Thr Glu Thr Pro Asp His Thr Asp Leu Met Lys Asn Leu Val He Gly 130 135 140 Glu Asp Gly Thr Pro Wing He Lys Gly Ser Pro Ser Lys Leu Arg Arg 145 150 155 160 He Leu Glu He Asn Ser Wing Leu Glu Thr Leu Lys Phe Glu Gly 165 170 175 Arg Glu Leu Ser Asp Glu Leu Val Trp Glu Arg He His Wing Thr Lys 180 185 190 25 Wing Wing Asp Leu Wing Ser Leu Val Tyr Thr Ser Gly Thr Thr Gly Arg a _______ ái__a ...: ... »__, lt * < -t < t '195 200 205 Pro Lys Gly Cys Glu Leu Ser His Tyr His Trp Leu Wing Glu Val Arg 210 215 220 Wing Leu He Thr Asn Asp He Gly Wing He Wing Met Pro Gly Ser Arg 225 230 235 240 Leu Leu Thr Phe Leu Pro Leu Ala His Val Leu Ala Arg Ala Val His 245 250 255 Leu Ala Phe Ala Val Thr Gly Ala Thr Gln Ser His Trp Ser Asp Phe 260 265 270 Ser Thr Leu Thr Leu Glu Leu Gln Arg Ser Arg Pro Asn Leu He Leu 275 280 285 Gly Val Pro Arg Val Phe Glu Lys Val Arg Asn Wing Wing Wing Wing Asn 290 295 300 Wing Wing Asp Gly Gly Wing He Lys Arg He Met Phe Glu Arg Wing Glu 305 310 315 320 Lys Ala Wing He Glu Tyr Ser Met Wing Ala Leu Asp Thr Ala Glu Gly Pro 325 330 335 Ser Lys Ser Gln Val Met Wing His Lys Wing Phe Asp Lys Leu Val Tyr 340 345 350 Ser Lys He Arg Wing Wing Val Gly Gly Asp Val Gln Tyr Wing He Thr 10 355 360 365 Gly Gly Be Wing Met Gly Gln Glu Leu Leu His Phe Phe Arg Gly Val 370 375 380 • Gly Met Thr He Tyr Glu Gly Tyr Gly Leu Thr Glu Be Wing Wing Wing 385 390 395 400 Wing Wing Val Asp Phe Thr Asp Gln Lys He Gly Thr Val Gly Lys Pro 405 410 415 Met Gly Gly Met Thr He Lys He Asn Glu Asp Gly Glu He Met Leu 420 425 430 Lys Gly Glu Met Leu Phe Gln Gly Tyr Trp Asn Asn Pro Glu Wing Thr 435 440 445 Wing Glu Wing Leu His Asp Gly Trp Phe Asn Thr Gly Asp Leu Gly Glu 15 450 455 460 Leu Leu Glu Ser Gly His Leu Val He Thr Gly Arg Lys Lys Asp Leu 465 470 475 480 He Val Thr Wing Gly Gly Lys Asn Val Ser Pro Gly Pro Met Glu Asp 485 490 495 He He Arg Ala His Pro Leu Val Ser Gln Ala Met Val Val Gly Asp 500 505 510 Gly Lys Pro Phe Val Gly Leu Leu Val Thr Leu Asp Pro Asp Met Leu • 515 520 525 Lys Arg Trp Lys Leu Asn His Asn He Wing Glu Ser Arg Thr Val Ser 530 535 540 Glu He Wing Thr Asp Pro Wing Leu Arg Wing Glu He Gln Asp Wing Val 20 545 550 555 560 Asn Asn Wing Asn Wing Thr Val Ser His Ser Glu Wing He Lys Arg Phe 565 570 575 Tyr He Leu Asp Arg Asp Leu Thr Glu Glu Wing Asp Glu Leu Thr Pro 580 585 590 Thr Leu Lys Val Lys Arg Asn Val Val Val Arg Arg Tyr Ala Asp Ala 595 600 605 He Asp His He Tyr Asn Arg 610 615 < 210 > 61 < 211 > 1047 25 < 212 > DNA A a. * .Í < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1024) < 223 > RXA01060"< 400 > 61 ttccatttac iacatctgt" te g¡actc < gegee cgaatgatgt cgcatcaaca 1bgagaageta 60 cttccatact "tttatctga" tt g¡ataagaatg gaicaaa < gaca atg aac cgc here etc 115 Met Asn Arg Thr Leu 1 5 cga here ctt ggc tgg ctt gct gcc gta att ca ga ga gat ccg gag ccc 163 Arg Thr Leu Gly Trp Leu Ala Ala Val He Gln Glu Asp Pro Glu Pro 10 15 20 tgg ttc acc act gat ccc gac acc g tat tat gtc ect tat gta aat agt 211 Trp Phe Thr Thr Asp Pro Asp Thr Asp Tyr Val Pro Tyr Val Asn Ser 25 30 35 ttc tea ttt gaa tcc ctt tcc etc gtt cca gat gct ctg atg ctg etc 259 Phe Ser Phe Glu Ser Leu Ser Leu Val Pro Asp Ala Leu Met Leu Leu 40 45 50 aaa cgt tet ctt ctt gcg atg gag cag cag gac etc cca gtg aag 307 Lys Arg Ser Leu His Leu Wing Met Glu Gln Gln Asp Leu Pro Val Lys 55 60 65 gat cta caa gaa gca ctg agg falls gta cta gtt ttc aaa ttc falls ttc 355 Asp Leu Gln Glu Ala Leu Arg His Val Leu Val Phe Lys Phe His Phe 70 75 80 85 agg gaa gag tgg gag ctg gaa tta gca tgg gac tcc gag cgg acc aag 403 Arg Glu Glu Trp Glu Leu Glu Leu Wing Trp Asp Ser Glu Arg Thr Lys 90 95 100 tet gcg gtg aga att att gag age here aaa gaa tet ctt gcc gat caa 451 Be Wing Val Arg He He Glu Be Thr Lys Glu Ser Leu Wing Asp Gln 105 110 115 tac aga gat tac aaa tac gca ttc ttg ect gag tta att ttc cag gaa 499 Tyr Arg Asp Tyr Lys Tyr Wing Phe Leu Pro Glu Leu He Phe Gln Glu 120 125 130 tea cgc ggg ate ttt gac ttt gag ctg gag gga tac acc etc aaa gta 547 Being Arg Gly He Phe Asp Phe Glu Leu Glu Gly Tyr Thr Leu Lys Val 135 140 145 gga caa age acg ctt tcc att ect tgg gac atg ate gcc aat ggt tat 595 Gly Gln Ser Thr Leu Ser He Pro Trp Asp Met He Wing Asn Gly Tyr 150 155 160 165 gtc ect gca agt ctt cgg aat ttt gga gaa tta atg gac cgt gac acc 643 Val Pro Wing Being Leu Arg Asn Phe Gly Glu Leu Met Asp Arg Asp Thr 170 175 180 gga gat gat gat gca gat ccc att ctg aga ect cga gaa etc aaa ttt 691 Gly Asp Leu Asp Wing Asp Pro He Leu Arg Pro Arg Glu Leu Lys Phe 185 190 195 gag ate cat aat tgt cca gat ctt aat ect tgg ata atg cgg gaa act 739 Glu He His Asn Cys Pro Asp Leu Asn Pro Trp He Met Arg Glu Thr 200 205 210 ttt gat ttc atg atg gaa ate gca act gaa here gga tgg ttc cat gct 787 Phe Asp Phe Met Met Glu He Ala Thr Glu Thr Gly Trp Phe His Wing 215 220 225 etc aac ccc gca tat aat tcc gtc tac acc tac gat ctt att tet cgc 835 Leu Asn Pro Ala Tyr Asn Ser Val Tyr Thr Tyr Asp Leu He Ser Arg 230 235 240 245 atg cca gat ttc ctt gtt gag ggg age ttt cgt ccg cat tea gtg aaa 883 Met Pro Asp Phe Leu Val Glu Gly Ser Phe Arg Pro His Ser Val Lys 250 255 260 cga tet tgg gaa aaa att caá aag ata gct aaa gct gtt gag tet tat 931 Arg Ser Trp Glu Lys He Gln Lys He Wing Lys Wing Val Glu Ser Tyr 265 270 275 gca tet falls gat tac tgc atg tea acg ctg here cat gac tac agg gca 979 Wing Ser His Asp Tyr Cys Met Be Thr Leu Thr His Asp Tyr Arg Ala 5 280 285 290 ate gag tta tcc ctg acct ect aaa act ga gaga cca age here 1024 He Glu Leu Ser Leu Thr Pro Thr Lys Thr Glu Glu Pro Ser Thr 295 300 305 taagaaaacc tcgcctgccc act 1047 < 210 > 62 < 211 > 308 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 62 JQ Met Asn Arg Thr Leu Arg Thr Leu Gly Trp Leu Wing Wing Val He Gln 1 5 10 15 Glu Asp Pro Glu Pro Trp Phe Thr Thr Asp Pro Asp Thr Asp Tyr Val ^ _P 20 25 30 Pro Tyr Val Asn Ser Phe Ser Phe Glu Ser Leu Ser Leu Val Pro Asp 35 40 45 Wing Leu Met Leu Leu Arg Ser Leu His Leu Wing Met Glu Gln Gln 50 55 60 Asp Leu Pro Val Lys Asp Leu Gln Glu Wing Leu Arg His Val Leu Val 65 70 75 80 Phe Lys Phe His Phe Arg Glu Glu Trp Glu Leu Glu Leu Wing Trp Asp 85 90 95 15 Ser Glu Arg Thr Lys Ser Wing Val Arg He He Glu Ser Thr Lys Glu 100 105 110 Ser Leu Wing Asp Gln Tyr Arg Asp Tyr Lys Tyr Ala Phe Leu Pro Glu 115 120 125 Leu He Phe Gln Glu Be Arg Gly He Phe Asp Phe Glu Leu Glu Gly 130 135 140 Tyr Thr Leu Lys Val Gly Gln Ser Thr Leu Ser He Pro Trp Asp Met 145 150 155 160 • He Wing Asn Gly Tyr Val Pro Wing Ser Leu Arg Asn Phe Gly Glu Leu 165 170 175 Met Asp Arg Asp Thr Gly Asp Leu Asp Wing Asp Pro He Leu Arg Pro 180 185 190 20 Arg Glu Leu Lys Phe Glu He His Asn Cys Pro Asp Leu Asn Pro Tr p 195 200 205 He Met Arg Glu Thr Phe Asp Phe Met Met Met Glu He Ala Thr Glu Thr 210 215 220 Gly Trp Phe His Ala Leu Asn Pro Ala Tyr Asn Ser Val Tyr Thr Tyr 225 230 235 240 Asp Leu He Ser Arg Met Pro Asp Phe Leu Val Glu Gly Ser Phe Arg 245 250 255 Pro His Ser Val Lys Arg Ser Trp Glu Lys He Gln Lys He Ala Lys 260 265 270 Wing Val Glu Ser Tyr Ala Ser His Asp Tyr Cys Met Ser Thr Leu Thr 275 280 285 25 His Asp Tyr Arg Ala He Glu Leu Ser Leu Thr Pro Thr Lys Thr Glu '- ** "' -" 'i I T' * "*" '* "290 295 300 Glu Pro Ser Thr 305 < 210 > 63 < 211 > 1848 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1825) < 223 > RXN01722 ctcattcccc tcgctaaaag ctgeataaag tttcgacgtt ttcaaagttg; attgcttgca 60 ctgtcgttgc, gtgtiegcatg ccccggctat tgttgattgc atg etc age acg atg 115 Met Leu Ser Thr Met 1 5 cag gac gtc cca ctg tea tta acc aga ate etc gag tac ggg tcc act 163 Gln Asp Val Pro Leu Ser Leu Thr Arg He Leu Glu Tyr Gly Ser Thr 10 15 20 gtt falls ggt gat act ttg ate ac ac tgg ggc ggt gcc gat ggc att 211 Val His Gly Asp Thr Leu He Thr Thr Trp Gly Gly Wing Asp Gly He 25 30 35 gaa caca gca cag caa act ttt agt gct gtg ggg gct aga gct gcg gct 259 Glu Gln Wing Gln Gln Thr Phe Wing Wing Val Gly Wing Arg Wing Wing Wing 40 45 50 ttg gct cat gcg ctg cat gat tet tta ggt att act ggg gat cag cga 307 Leu Ala His Ala Leu His Asp Ser Leu Gly He Thr Gly Asp Gln Arg 55 60 65 gtg gcg tcg atg etc tat aac tgc gcg gaa falls atg gaa act atg ttt 355 Val Ala Ser Met Leu Tyr Asn Cys Ala Glu His Met Glu Thr Met Phe 70 75 80 85 gca gtc gca tgc atg ggt gcc gtg ttt aat ccg ctg aac aag cag ttg 403 Wing Val Wing Cys Met Gly Wing Val Phe Asn Pro Leu Asn Lys Gln Leu 90 95 100 atg aat gat cag att gtg ttc att etc aat falls tet gaa gct gaa gtg 451 Met As Asp Gln He Val Phe He Leu Asn His Ser Glu Ala Glu Val 105 110 115 gtt ate gct gat ccg cgc atg gct gaa caa ttg ggt gag ate tta aaa 499 Val He Wing Asp Pro Arg Met Wing Glu Gln Leu Gly Glu He Leu Lys 120 125 130 gaa here cca aaa gtt cgt gcc gtg gtg ttt att gga ccg aat gat ttc 547 Glu Thr Pro Lys Val Arg Wing Val Val Phe He Gly Pro Asn Asp Phe 135 140 145 tet age gcg gcg gcc falls atg ccg gag gga atg aag ctg tat tcc tat 595 Being Wing Wing Wing His Met Pro Glu Gly Met Lys Leu Tyr Being Tyr 150 155 160 165 gaa gcg etc ctt gac ggc cgt tcc act gtt tac aac tgg ccc gag cag 643 Glu Ala Leu Leu Asp Gly Arg Ser Thr Val Tyr Asn Trp Pro Glu Gln 170 175 180 gat gaa cgc act gct gct gca att tgc tat tcc acc ggt here tcg gga 691 Asp Glu Arg Thr Wing Wing Wing He Cys Tyr Ser Thr Gly Thr Ser Gly 185 190 195 ccg cg aag ggt gtg gtg tat tcc falls cgc tcg ctt tat tta cag tcg 739 Pro Pro Lys Gly Val Val Tyr Ser His Arg Ser Leu Tyr Leu Gln Ser . & * -, i 200 205 210 ttg age ttg cgc acc acg gat tcc etc gca gtg gaa falls ggc gaa acg 787 Leu Ser Leu Arg Thr Thr Asp Ser Leu Wing Val Glu His Gly Glu Thr 215 220 225 ttc ctg tgc tgt gtg ccg att tac falls gtc etc age tgg ggc gtg ccg 835 Phe Leu Cys Cys Val Pro He Tyr His Val Leu Ser Trp Gly Val Pro 230 235 240 245 ate gca gcg ttt atg tcc ggc act ccc ctg gtg ctt ect gga ccg gat 883 c He Ala Wing Phe Met Ser Gly Thr Pro Leu Val Leu Pro Gly Pro Asp 250 255 260 ctt tet gcg ccg here ttg gca aag ate att tcc acc acg ctg ect cgc 931 Leu Ser Wing Pro Thr Leu Wing Lys He He Ser Thr Thr Leu Pro Arg 265 270 275 gtg gcg cat ggc gtg ect act etc tgg att cag ctg atg gtt falls tac 979 Val Ala His Gly Val Pro Thr Leu Trp He Gln Leu Met Val His Tyr 280 285 290 ctg aaa aat ccc cca gag cgt atg tet ctg cgt gag cta tac gtg ggc 1027 Leu Lys Asn Pro Pro Glu Arg Met Ser Leu Arg Glu Leu Tyr Val Gly 295 300 305 ggt tet gcg gtg ect cca ate gtg ate acc atg tgg gag cag cgc tat 1075 j0 Gly Ser Ala Val Pro Pro He Val He Thr Met Trp Glu Gln Arg Tyr 310 315 320 325 ggc gtg gat gtt gtc falls gtg tgg ggt atg acg gaa acc tcc acc gtg 1123 • Gly Val Asp Val Val His Val Trp Gly Met Thr Glu Thr Ser Thr Val 330 335 340 ggt act gtg tet cgc cca cca tea ggt gtt tet ggt gaa age cgg tgg 1171 Gly Thr Val Ser Arg Pro Pro Ser Gly Val Ser Gly Glu Ser Arg Trp 345 350 355 aat tat cga gtc ccc ggc cg ct tc ccc ccc gcc tc cg cgc 1219 Asn Tyr Arg Val Ser Gln Gly Arg Phe Pro Wing Ser Leu Gln Tyr Arg 360 365 370 att gtc aac gac ggc cag gtc atg gcg tcc acc gac cgc aac gag ggc 1267 15 He Val Asn Asp Gly Gln Val Met Wing Ser Thr Asp Arg Asn Glu Gly 375 380 385 gag att cag gtc cgc ggt ccg tgg gtg act gca agt tac tcc falls ccc 1315 Glu He Gln Val Arg Gly Pro Trp Val Thr Wing Ser Tyr Phe His Pro 390 395 400 405 gat gtg gaa aaa gaa ggt ggc acc gcc tea here tc cgc gac cat gac 1363 Asp Val Glu Lys Glu Gly Gly Thr Wing Ser Thr Phe Arg Asp His Asp 410 415 420 gtt gaa gag gaa aac gat gag etc ttc acc gcc gac ggc tgg ctg cgc 1411 Val Glu Glu Glu Asn Asp Glu Leu Phe Thr Wing Asp Gly Trp Leu Arg 425 430 435 acc ggg gac gtt gga tet g tc acc age gat gga ttc etc acc ate ca 1459 20 Thr Gly Asp Val Gly Ser Val Thr Ser Asp Gly Phe Leu Thr He Gln 440 445 450 gac cgc gcc cgc gat gtc ate cgt tet ggc ggc gag tgg att tac tcc 1507 Asp Arg Wing Arg Asp Val He Arg Ser Gly Gly Glu Trp He Tyr Ser 455 460 465 gct cag ctg gaa aac etc. ate gtg gct acg gaa gag gtt gtc gaa tgc 1555 Ala Gln Leu Glu Asn Leu He Val Ala Thr Glu Glu Val Val Glu Cys 470 475 480 485 gcc gtc att ggc ttc ccc gat gac aag tgg gtg gaa cgt ccc etc gca 1603 Wing Val He Gly Phe Pro Asp Asp Lys Trp Val Glu Arg Pro Leu Wing 490 495 500 gtc acc atg etc tac ccc ggc att gaa cgc cgg gaa ac acc gcc gag 1651 25 Val Thr Met Leu Tyr Pro Gly He Glu Arg Thr Arg Glu Thr Ala Glu 505 510 515 cgc etc cgc gat cata ctt cgc gac cgc cta ccc aac tgg atg ctg cca 1699 Arg Leu Arg Asp Gln Leu Arg Asp Arg Leu Pro Asn Trp Met Leu Pro 520 525 530 gaa tat tgg here ttt gtt gat gag gtg gat aaa acc tcc gtc ggt aaa 1747 Glu Tyr Trp Thr Phe Val Asp Glu Val Asp Lys Thr Ser Val Gly Lys 535 540 545 tat gac aag aag gac etc cgc aac falls ctc cgc aac ggc gat ttc gaa 1795 Tyr Asp Lys Lys Asp Leu Arg Asn His Leu Arg Asn Gly Asp Phe Glu 550 555 560 565 gta att aag ctt aaa ggg cca ggt gaa aaa taacttccct atttattccg 1845 Val He Lys Leu Lys Gly Pro Gly Glu Lys 570 575 gct 1848 < 210 > 64 < 211 > 575 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 64 Met Leu Ser Thr Met Gln Asp Val Pro Leu Ser Leu Thr Arg He Leu 1 5 10 15 Glu Tyr Gly Ser Thr Val His Gly Asp Thr Leu He Thr Thr Trp Gly 20 25 30 Gly Wing Asp Gly He Glu Gln Wing Gln Gln Thr Phe Ser Wing Val Gly 35 40 45 Wing Arg Wing Wing Wing Leu Wing His Wing Leu His Asp Being Leu Gly He 50 55 60 Thr Gly Asp Gln Arg Val Wing Being Met Leu Tyr Asn Cys Wing Glu His 65 70 75 80 Met Glu Thr Met Phe Wing Val Wing Cys Met Gly Wing Val Phe Asn Pro 85 90 95 Leu Asn Lys Gln Leu Met Asn Asp Gln He Val Phe He Leu Asn His 100 105 110 Ser Glu Wing Glu Val Val He Wing Asp Pro Arg Met Wing Glu Gln Leu 115 120 125 Gly Glu He Leu Lys Glu Thr Pro Lys Val Arg Wing Val Val Phe He 130 135 140 Gly Pro Asn Asp Phe Ser Wing Wing Wing His Met Pro Glu Gly Met 145 150 155 160 Lys Leu Tyr Ser Tyr Glu Wing Leu Leu Asp Gly Arg Ser Thr Val Tyr 165 170 175 Asn Trp Pro Glu Gln Asp Glu Arg Thr Wing Wing Wing He Cys Tyr Ser 180 185 190 Thr Gly Thr Ser Gly Pro Pro Lys Gly Val Val Tyr Ser His Arg Ser 195 200 205 Leu Tyr Leu Gln Ser Leu Ser Leu Arg Thr Thr Asp Ser Leu Wing Val 210 215 220 Glu His Gly Glu Thr Phe Leu Cys Cys Val Pro He Tyr His Val Leu 225 230 235 240 Ser Trp Gly Val Pro He Wing Wing Phe Met Ser Gly Thr Pro Leu Val 245 250 255 Leu Pro Gly Pro Asp Leu Be Wing Pro Thr Leu Wing Lys He He Ser 260 265 270 Thr Thr Leu Pro Arg Val Wing His Gly Val Pro Thr Leu Trp He Gln 275 280 285 ..: jjg¡ jn¡m Leu Met Val His Tyr Leu Lys Asn Pro Pro Glu Arg Met Ser Leu Arg 290 295 300 Glu Leu Tyr Val Gly Gly Ser Wing Val Pro Pro He Val He Thr Met 305 310 315 320 Trp Glu Gln Arg Tyr Gly Val Asp Val Val His Val Trp Gly Met Thr 325 330 335 Glu Thr Ser Thr Val Gly Thr Val Ser Arg Pro Pro Ser Gly Val Ser 340 345 350 Gly Glu Ser Arg Trp Asn Tyr Arg Val Ser Gln Gly Arg Phe Pro Ala 355 360 365 Ser Leu Gln Tyr Arg He Val Asn Asp Gly Gln Val Met Wing Ser Thr 370 375 380 Asp Arg Asn Glu Glu Glu He Gln Val Arg Gly Pro Trp Val Thr Wing 385 390 395 400 Ser Tyr Phe His Pro Asp Val Glu Lys Glu Gly Gly Thr Wing Ser Thr 405 410 415 Phe Arg Asp His Asp Val Glu Glu Glu Asn Asp Glu Leu Phe Thr Wing 420 425 430 Asp Gly Trp Leu Arg Thr Gly Asp Val Gly Ser Val Thr Ser Asp Gly 435 440 445 10 Phe Leu Thr He Gln Asp Arg Ala Arg Asp Val He Arg Ser Gly Gly 450 455 460 Glu Trp He Tyr Ser Wing Gln Leu Glu Asn Leu He Val Wing Thr Glu 465 470 475 480 Glu Val Val Glu Cys Ala Val He Gly Phe Pro Asp Asp Lys Trp Val 485 490 495 Glu Arg Pro Leu Wing Val Thr Met Leu Tyr Pro Gly He Glu Arg Thr 500 505 510 Arg Glu Thr Wing Glu Arg Leu Arg Asp Gln Leu Arg Asp Arg Leu Pro 515 520 525 Asn Trp Met Leu Pro Glu Tyr Trp Thr Phe Val Asp Glu Val Asp Lys 530 535 540 g Thr Ser Val Gly Lys Tyr Asp Lys Lys Asp Leu Arg Asn His Leu Arg 545 550 555 560 Asn Gly Asp Phe Glu Val He Lys Leu Lys Gly Pro Gly Glu Lys 565 570 575 < 210 > 65 < 211 > 1848 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS 20 < 222 > (101) .. (1825) < 223 > FRXA01722 < 220 > < 221 > VARIANT < 222 > 479 < 223 > Xaa = Thr < 220 > < 221 > VARIANT < 222 > 574 < 223 > Xaa = Glu 25 g ^ ¡gg¡ g ¡*, **. «** JU < 400 > 65 ctcattcccc tcgctaaaag ctgeataaag tttcgacgtt ttcaaagttg attgcttgca 60 ctgtcgttgc gtgtcgcatg ccccggctat tgttgattgc atg etc age acg atg 115 Met leu ser thr Met 1 Arg He Leu Glu Tyr Gly Ser Thr 10 15 20 • gtt falls ggt gat act ttg ate acc acg tgg ggc ggt gcc gat ggc att 211 Val His Gly Asp Thr Leu He Thr Thr Trp Gly Gly Wing Asp Gly He 25 30 35 gaa ca gca cag ca gt gtg gg gg gg gg gg gg gg gg gg gg gg Gln Gln Gln Gln Thr Phe Ser Wing Val Gly Wing Arg Wing Wing Wing 40 45 50 ttg gct cat gcg ctg cat gat tet tta ggt att act ggg gat cag cga 307 Leu Ala His Ala Leu His Asp Ser Leu Gly He Thr Gly Asp Gln Arg 55 60 65 gtg gcg tcg atg etc tat aac tgc gcg gaa falls atg gaa act at ttt 355 Val Ala Ser Met Leu Tyr Asn Cys Ala Glu His Met Glu Thr Met Phe 70 75 80 85 gca gtc gca tgc atg ggt gcc gtg ttt aat ccg ctg aac aag cag ttg 403 10 Wing Val Wing Cys Met Gly Wing Val Phe Asn Pro Leu Asn Lys Gln Leu 90 95 100 • atg aat gat cag att gtg ttc att etc aat falls tet gaa gct gaa gtg 451 Met As Asp Gln He Val Phe He Leu Asn His Ser Glu Ala Glu Val 105 110 115 gtt ate gct gat ccg cgc atg gct gaa caa ttg ggt gag ate tta aaa 499 Val He Wing Asp Pro Arg Met Wing Glu Gln Leu Gly Glu He Leu Lys 120 125 130 gaa here cca aaa gtt cgt gcc gtg gtg ttt att gga ccg aat gat ttc 547 Glu Thr Pro Lys Val Arg Wing Val Val Phe He Gly Pro Asn Asp Phe 135 140 145 tet age gcg gcg gcc falls atg ccg gag gga atg aag ctg tat tcc tat 595 15 Being Wing Wing Wing His Met Pro Glu Gly Met Lys Leu Tyr Ser Tyr 150 155 160 165 gaa gcg etc ctt gac ggc cgt tcc act gtt tac aac tgg ccc gag cag 643 Glu Ala Leu Leu Asp Gly Arg Ser Thr Val Tyr Asn Trp Pro Glu Gln 170 175 180 gat gaa cgc act gct gct gca att tgc tat tcc acc ggt here tcg gga 691 Asp Glu Arg Thr Wing Wing Wing He Cys Tyr Ser Thr Gly Thr Ser Gly • 185 190 195 ccg ccg aag ggt gtg gtg tat tcc falls cgc tcg ctt tat tta cag tcg 739 Pro Pro Lys Gly Val Val Tyr Ser His Arg Ser Leu Tyr Leu Gln Ser 200 205 210 20 ttg age ttg cgc acc acg gat tcc etc gca gtg gaa falls ggc gaa acg 787 Leu Ser Leu Arg Thr Thr Thr Asp Ser Leu Wing Val Glu His Gly Glu Thr 215 220 225 ttc ctg tgc tgt gtg ccg att tac drops gtc etc age tgg ggc gtg ccg 835 Phe Leu Cys Cys Val Pro He Tyr His Val Leu Ser Trp Gly Val Pro 230 235 240 245 ate gca gcg ttt atg tcc ggc act ccc ctg gtg ctt ect gga ccg gat 883 He Ala Ala Phe Met Ser Gly Thr Pro Leu Val Leu Pro Gly Pro Asp 250 255 260 ctt tet gcg ccg here tt g gca aag ate att tcc acc acg ctg ect cgc 931 Leu Be Wing Pro Thr Leu Wing Lys He He Be Thr Thr Leu Pro Arg 265 270 275 25 gtg gcg cat ggc gtg ect act etc tgg att cag ctg atg gtt fall tac 979 Val Ala His Gly Val Pro Thr Leu Trp He Gln Leu Met Val His Tyr 280 285 290 ctg aaa aat ccc cca gag cgt atg tet ctg cgt gag cta tac gtg ggc 1027 Leu Lys Asn Pro Pro Glu Arg Met Ser Leu Arg Glu Leu Tyr Val Gly 295 300 305 ggt tet gcg gtg ect cca ate gtg ate acc atg tgg gag cag cgc tat 1075 Gly Ser Ala Val Pro Pro He Val He Thr Met Trp Glu Gln Arg Tyr 310 315 320 325 ggc gtg gat gtt gtc falls gtg tgg ggt atg acg gaa acc tcc action gtg 1123 Gly Val Asp Val Val His Val Trp Gly Met Thr Glu Thr Ser Thr Val 330 335 340 ggt act gtg tet cgc cca cca tea ggt gtt tet ggt gaa age cgg tgg 1171 Gly Thr Val Ser Arg Pro Pro Ser Gly Val Ser Gly Glu Ser Arg Trp 345 350 355 aat tat cga gtc ccc cg ggc cga tc ccc ccc gcc ccc tg cgc cgc 1219 Asn Tyr Arg Val Ser Gln Gly Arg Phe Pro Wing Ser Leu Gln Tyr Arg 360 365 370 att gtc aac gac ggc cag gtc atg gcg tcc acc gac cgc aac gag ggc 1267 He Val Asn Asp Gly Gln Val Met Wing Ser Thr Asp Arg Asn Glu Gly 375 380 385 10 gag att cag gtc cgc ggt ccg tgg gtg act gca gt agt tac ttc falls ccc 1315 Glu He Gln Val Arg Gly Pro Trp Val Thr Wing Ser Tyr Phe His Pro 390 395 400 405 gat gtg gaa aaa gaa ggt ggc acc gcc tea here ttc cgc gac cat gac 1363 • Asp Val Glu Lys Glu Gly Gly Thr Wing Ser Thr Phe Arg Asp His Asp 410 415 420 gtt Gaa gag gaa aac gat gag etc ttc acc gcc gac ggc tgg ctg cgc 1411 Val Glu Glu Glu Asn Asp Glu Leu Phe Thr Wing Asp Gly Trp Leu Arg 425 430 435 acc ggg gac gtt tet gtc gtc acc gtc gat ggac acc acct acc 1459 Thr Gly Asp Val Gly Ser Val Thr Ser Asp Gly Phe Leu Thr He Gln 440 445 450 15 gac cgc gcc cgc gat gtc ate cgt tet ggc ggc gag tgg att tac tcc 1507 Asp Arg Wing Arg Asp Val He Arg Ser Gly Glu Glu Trp He Tyr Ser 455 460 465 gct cag ctg gaa aac etc. ate gtg gct gs ac gaa gag gtt gtc gaa tgc 1555 Ala Gln Leu Glu Asn Leu He Val Wing Xaa Glu Glu Val Val Glu Cys 470 475 480 485 gcc gtc att ggc ttc ccc gat gac aag tgg gtg gaa cgt ccc etc gca 1603 Wing Val He Gly Phe Pro Asp Asp Lys Trp Val Glu Arg Pro Leu Wing 490 495 500 • gtc acc atg etc tac ccc ggc att gaa cgc acc cgg gaa acc gcc gag 1651 Val Thr Met Leu Tyr Pro Gly He Glu Arg Thr Arg Glu Thr Wing Glu 505 510 515 20 cgc etc cgc gat ca ctt cgc gac cgc cta ccc aac tgg atg ctg cca 1699 Arg Leu Arg Asp Gln Leu Arg Asp Arg Leu Pro Asn Trp Met Leu Pro 520 525 530 gaa tat tgg here ttt gtt gat gag gtg gat aaa acc tcc gtc ggt aaa 1747 Glu Tyr Trp Thr Phe Val Asp Glu Val Asp Lys Thr Ser Val Gly Lys 535 540 545 tat gac aag aag gac etc cgc aac falls ctc cgc aac ggc gat ttc gaa 1795 Tyr Asp Lys Asp Leu Arg Asn His Leu Arg Asn Gly Asp Phe Glu 550 555 560 565 gta att aag ctt aaa ggg cca ggt gar aaa taacttccct a .tttaittCC: g 1845 Val He Lys Leu Lys Gly Pro Gly Xaa Lys 570 575 25 gct 1848 <; 210 > 66 < 211 > 575 < 212 > PRT < 213 > Corynebacterium glutamicum < 220 > < 221 > VARIANT < 222 > 479 < 223 > Xaa = Thr < 220 > < 221 > VARIANT < 222 > 574 < 223 > Xaa - Glu < 400 > 66 Met Leu Ser Thr Met Gln Asp Val Pro Leu Ser Leu Thr Arg He Leu 1 5 10 15 Glu Tyr Gly Ser Thr Val His Gly Asp Thr Leu He Thr Thr Trp Gly 20 25 30 10 Gly Wing Asp Gly He Glu Gln Wing Gln Gln Thr Phe Ser Wing Val Gly 35 40 45 • Wing Arg Wing Wing Wing Leu Wing His Wing Leu His Asp Being Leu Gly He 50 55 60 Thr Gly Asp Gln Arg Val Wing Being Met Leu Tyr Asn Cys Wing Glu His 65 70 75 80 Met Glu Thr Met Phe Wing Val Wing Cys Met Gly Wing Val Phe Asn Pro 85 90 95 Leu Asn Lys Gln Leu Met Asn Asp Gln He Val Phe He Leu Asn His 100 105 110 Ser Glu Wing Glu Val Val He Wing Asp Pro Arg Met Wing Glu Gln Leu 15 115 120 125 Gly Glu He Leu Lys Glu Thr Pro Lys Val Arg Wing Val Val Phe He 130 135 140 Gly Pro Asn Asp Phe Ser Wing Wing Ala His Met Pro Glu Gly Met 145 150 155 160 Lys Leu Tyr Being Tyr Glu Wing Leu Leu Asp Gly Arg Being Thr Val Tyr 165 170 175 Asn Trp Pro Glu Gln Asp Glu Arg Thr Wing Wing Wing He Cys Tyr Ser • 180 185 190 Thr Gly Thr Ser Gly Pro Pro Lys Gly Val Val Tyr Ser His Arg Ser 195 200 205 Leu Tyr Leu Gln Ser Leu Ser Leu Arg Thr Thr Asp Ser Leu Wing Val 20 210 215 220 Glu His Gly Glu Thr Phe Leu Cys Cys Val Pro He Tyr His Val Leu 225 230 235 240 Ser Trp Gly Val Pro He Wing Wing Phe Met Ser Gly Thr Pro Leu Val 245 250 255 Leu Pro Gly Pro Asp Leu Be Wing Pro Thr Leu Wing Lys He He Ser 260 265 270 Thr Thr Leu Pro Arg Val Wing His Gly Val Pro Thr Leu Trp He Gln 275 280 285 Leu Met Val His Tyr Leu Lys Asn Pro Pro Glu Arg Met Ser Leu Arg 290 295 300 Glu Leu Tyr Val Gly Gly Ser Wing Val Pro Pro He Val He Thr Met 25 305 310 315 320 - "- ^ # *« "'-. to * . í *.

Trp Glu Gln Arg Tyr Gly Val Asp Val Val His Val Trp Gly Met Thr 325 330 335 Glu Thr Ser Thr Val Gly Thr Val Ser Arg Pro Pro Ser Gly Val Ser 340 345 350 Gly Glu Ser Arg Trp Asn Tyr Arg Val Ser Gln Gly Arg Phe Pro Wing 355 360 365 Ser Leu Gln Tyr Arg He Val Asn Asp Gly Gln Val Met Wing Ser Thr 370 375 380 Asp Arg Asn Glu Glu Glu He Gln Val Arg Gly Pro Trp Val Thr Wing 385 390 395 400 Ser Tyr Phe His Pro Asp Val Glu Lys Glu Gly Gly Thr Ala Ser Thr 405 410 415 Phe Arg Asp His Asp Val Glu Glu Glu Asn Asp Glu Leu Phe Thr Wing 420 425 430 Asp Gly Trp Leu Arg Thr Gly Asp Val Gly Ser Val Thr Ser Asp Gly 435 440 445 Phe Leu Thr He Gln Asp Arg Ala Arg Asp Val He Arg Ser Gly Gly 450 455 460 Glu Trp He Tyr Ser Ala Gln Leu Glu Asn Leu He Val Ala Xaa Glu 465 470 475 480 10 Glu Val Val Glu Cys Ala Val He Gly Phe Pro Asp Asp Lys Trp Val 485 490 495 Glu Arg Pro Leu Wing Val Thr Met Leu Tyr Pro Gly He Glu Arg Thr • 500 505 510 Arg Glu Thr Wing Glu Arg Leu Arg Asp Gln Leu Arg Asp Arg L eu Pro 515 520 525 Asn Trp Met Leu Pro Glu Tyr Trp Thr Phe Val Asp Glu Val Asp Lys 530 535 540 Thr Ser Val Gly Lys Tyr Asp Lys Lys Asp Leu Arg Asn His Leu Arg 545 550 555 560 Asn Gly Asp Phe Glu Val He Lys Leu Lys Gly Pro Gly Xaa Lys 565 570 575 15 < 210 > 67 < 211 > 1401 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (137Í <223> RXA01644 < 400> 67 20 gtaggtagag gcttgtggtc actacttgtg gccacatttt aaaaaaatge acaagaagag 60 aaagcaaagc attatgagta acgccgtagc gcaggacctc atg acc ate gcc gac 115 Met Thr He Ala Asp 1 5 ate gtc gag gcc acg acc act gca ccc ate cca tcc cae ate act gcc 163 He Val Glu Wing Thr Thr Thr Wing Pro He Pro Phe His He Thr Wing 10 15 20 ttc gat gga age ttc act ggc ect gaa gat gct ccc tac cag ctg ttt 211 Phe Asp Gly Be Phe Thr Gly Pro Glu Asp Wing Pro Tyr Gln Leu Phe 25 30 35 gtt gcc aac acg gat gca gta tcc tac ate gca here gcg cca gga gat 259 Val Wing Asn Thr Asp Wing Val Ser Tyr He Wing Thr Wing Pro Gly Asp 25 40 45 50 ttg ggt ttg gca cgt gcc tac etc atg gga gac etc ate gtg gaa ggt 307 Leu Gly Leu Wing Arg Wing Tyr Leu Met Gly Asp Leu He Val Glu Gly 55 60 65 gag cat ccc ggc cat ect tat ggg ate ttt gat gcg ttg aag gag ttc 355 Glu His Pro Gly His Pro Tyr Gly He Phe Asp Ala Leu Lys Glu Phe 70 75 80 85 tac cgc tgc ttc aaa cgc cca gat gca tcc acc acc ttg cag ate atg 403 Tyr Arg Cys Phe Lys Arg Pro Asp Wing Ser Thr Thu Leu Gln He Met 90 95 100 tgg act ctg cgg aaa atg aat gcc tta aaa ttc cag gaa att cca cca 451 Trp Thr Leu Arg Lys Met Asn Wing Leu Lys Phe Gln Glu He Pro Pro 105 110 115 atg gaa ca gcc ect gca tgg cgt aaa gca ctg ate aac ggg cta gca 499 Met Glu Gln Ala Pro Wing Trp Arg Lys Wing Leu He Asn Gly Leu Wing 120 125 130 tcc agg falls tcg aaa tcc cgc gac aag aaa gcc att age tac falls tac 547 Ser Arg His Ser Lys Ser Arg Asp Lys Lys Wing He Ser Tyr His Tyr 135 140 145 gac gtg ggc aat gag ttc tac tcc ctg ttt tta gat gat tcc atg acc 595 Asp Val Gly Asn Glu Phe Tyr Ser Leu Phe Leu Asp Asp Ser Met Thr 150 155 160 165 tat acc tgc gcg tat tat cca acg cca gaa tea agt ttg gaa gaa gcc 643 Tyr Thr Cys Ala Tyr Tyr Pro Thr Pro Glu Ser Ser Leu Glu Glu Wing 170 175 180 caa gaa aac aaa tac cgc etc ate ttt gaa aaa ctg cgt ctg aaa gaa 691 Gln Glu Asn Lys Tyr Arg Leu He Phe Glu Lys Leu Arg Leu Lys Glu 185 190 195 ggc gat cgc etc cta gac gtg gga tgc ggt tgg gga ggc atg gtc cgc 739 Gly Asp Arg Leu Leu Asp Val Gly Cys Gly Trp Gly Gly Met Val Arg 200 205 210 tac gcc gcc aaa falls ggt gtg aaa gcc ate gga gtt acg ctg tet gaa 787 Tyr Ala Ala Lys His Gly Val Lys Ala He Gly Val Thr Leu Ser Glu 215 220 225 cag tat tat gag tgg ggt ca gca gag ate aaa cgc ca ggt ttg gaa 835 Gln Gln Tyr Glu Trp Gly Gln Wing Glu He Lys Arg Gln Gly Leu Glu 230 235 240 245 gac etc gcg gaa att cgc ttc atg gat tac cgc gat gtt cca gaa act 883 Asp Leu Wing Glu He Arg Phe Met Asp Tyr Arg Asp Val Pro Glu Thr 250 255 260 gga ttc gat gcg ate ate gca ate ggc ate att gaa cae ate ggt gtg 931 Gly Phe Asp Wing He Wing Wing He Gly He He Glu His He Gly Val 265 270 275 aac aac tat ccc gac tac ttt gaa ttg etc age age aaa etc aaa here 979 Asn Asn Tyr Pro Asp Tyr Phe Glu Leu Leu Ser Ser Lys Leu Lys Thr 280 285 290 ggc gga ctg atg etc aac falls age ate acc tac cca gac aac cgc ccc 1027 Gly Gly Leu Met Leu Asn His Ser He Thr Tyr Pro Asp Asn Arg Pro 295 300 305 cgc falls gca ggt gca ttt att gat cgc tac att tcc ccc gac ggt gaa 1075 Arg His Wing Gly Wing Phe He Asp Arg Tyr He Phe Pro Asp Gly Glu 310 315 320 325 etc act ggc tet ggc acc ctg ate aag cag atg cag gac aac ggt ttc 1123 Leu Thr Gly Ser Gly Thr Leu He Lys His Met Gln Asp Asn Gly Phe 330 335 340 gaa gtg ctg falls gaa gaa aac etc cgc ttt gat tac cac cgc acc ctg 1171 Glu Val Leu His Glu Glu Asn Leu Arg Phe Asp Tyr Gln Arg Thr Leu 345 350 355 falls gcg tgg tgc gaa aac etc aaa gaa aat tgg gag gaa gca gtt gaa 1219 His Wing Trp Cys Glu Asn Leu Lys Glu Asn Trp Glu Glu Wing Val Glu 360 365 370 etc gcc ggt gac ccc act gca cga etc ttt ggc ctg tac atg gca ggt 1267 Leu Wing Gly Glu Pro Thr Wing Arg Leu Phe Gly Leu Tyr Met Wing Gly 375 380 385 tcg gag tgg gga ttt gcc falls aac ate gtc cag ctg falls ca gta ctg 1315 Ser Glu Trp Gly Phe Ala His Asn He Val Gln Leu His Gln Val Leu 390 395 400 405 ggt gtg aaa etc gat gag cag gga agt cgc gga gaa gtt ect gaa aga 1363 Gly Val Lys Leu Asp Glu Gln Gly Ser Arg Gly Glu Val Pro Glu Arg 410 415 420 atg tgg tgg act ate taaagaaaca atgtttcttt tta 1401 Met Trp Trp Thr He 425 < 210 > 68 < 211 > 426 < 212 > PRT < 213 > Corynebacterium glutamicum 10 < 400 > 68 Met Thr He Wing Asp He Val Glu Wing Thr Thr Thr Ala Pro He Pro 1 5 10 15 • Phe His He Thr Wing Phe Asp Gly Ser Phe Thr Gly Pro Glu Asp Wing 20 25 30 Pro Tyr Gln Leu Phe Val Wing Asn Thr Asp Ala Val Ser Tyr He Ala 35 40 45 Thr Ala Pro Gly Asp Leu Gly Leu Ala Arg Ala Tyr Leu Met Gly Asp 50 55 60 Leu He Val Glu Gly Glu His Pro Gly His Pro Tyr Gly He Phe Asp 65 70 75 80 15 Wing Leu Lys Glu Phe Tyr Arg Cys Phe Lys Arg Pro Asp Wing Ser Thr 85 90 95 Thr Leu Gln He Met Trp Thr Leu Arg Lys Met Asn Wing Leu Lys Phe 100 105 110 Gln Glu He Pro Pro Met Glu Gln Ala Pro Wing Trp Arg Lys Ala Leu 115 120 125 He Asn Gly Leu Ala Ser Arg His Ser Lys Ser Arg Asp Lys Lys Wing 130 135 140 He Ser Tyr His Tyr Asp Val Gly Asn Glu Phe Tyr Ser Leu Phe Leu • 145 150 155 160 Asp Asp Ser Met Thr Tyr Thr Cys Wing Tyr Tyr Pro Thr Pro Glu Ser 165 170 175 20 Ser Leu Glu Glu Wing Gln Glu Asn Lys Tyr Arg Leu He Phe Glu Lys 180 185 190 Leu Arg Leu Lys Glu Gly Asp Arg Leu Leu Asp Val Gly Cys Gly Trp 195 200 205 Gly Gly Met Val Arg Tyr Wing Wing Lys His Gly Val Lys Wing He Gly 210 215 220 Val Thr Leu Ser Glu Gln Gln Tyr Glu Trp Gly Gln Wing Glu He Lys 225 230 235 240 Arg Gln Gly Leu Glu Asp Leu Wing Glu He Arg Phe Met Asp Tyr Arg 245 250 255 Asp Val Pro Glu Thr Gly Phe Asp Wing He Wing Wing He Gly He He 260 265 270 25 Glu His He Gly Val Asn Asn Tyr Pro Asp Tyr Phe Glu Leu Leu Ser 275 280 285 Ser Lys Leu Lys Thr Gly Gly Leu Met Leu Asn His Ser He Thr Tyr 290 295 300 Pro Asp Asn Arg Pro Arg His Wing Gly Wing Phe He Asp Arg Tyr He 305 310 315 320 Phe Pro Asp Gly Glu Leu Thr Gly Ser Gly Thr Leu He Lys His Met 325 330 335 Gln Asp Asn Gly Phe Glu Val Leu His Glu Glu Asn Leu Arg Phe Asp • 340 345 350 Tyr Gln Arg Thr Leu His Wing Trp Cys Glu Asn Leu Lys Glu Asn Trp 355 360 365 Glu Glu Wing Val Glu Leu Wing Gly Glu Pro Thr Wing Arg Leu Phe Gly 370 375 380 Leu Tyr Met Wing Gly Ser Glu Trp Gly Phe Wing His Asn He Val Gln 385 390 395 400 Leu His Gln Val Leu Gly Val Lys Leu Asp Glu Gln Gly Ser Arg Gly 405 410 415 Glu Val Pro Glu Arg Met Trp Trp Thr He 420 425 10 < 210 > 69 < 211 > 1437 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1414) < 223 > RXA02029 < 400 > 69 cgcacgt; here ictacttttag cagtt;? Aece gccgaacttt cttgattaag tattcattga 60 15 gcgttcttgg < cataaatccc actggaggtg catcaaacgt atg gca gag gca cgt 115 Met Wing Glu Wing Arg 1 5 ttg cgc cat ctt gaa ccc att gat gtg gag gag tgg ect ggg gtg gcg 163 Leu Arg His Leu Glu Pro He Asp Val Glu Glu Trp Pro Gly Val Wing 10 15 20 gca gaa 211 Ala Glu cta gga 259 Tyr Arg Phe Wing Lys Wing Cys Ser Asn Wing Gly Leu Val Leu Leu Gly 40 45 50 20 aat gac ccg gat etc att att gat cat gag gata tta ttc tea cgt ttg 307 Asn Asp Pro Asp Leu He He Asp His Glu Glu Leu Phe Ser Arg Leu 55 60 65 gcc gca tcg ggc tgg ctg ggg etc gct gag age tac atg gca ggc gag 355 Wing Wing Ser Gly Trp Leu Gly Leu Wing Glu Ser Tyr Met Wing Gly Glu 70 75 80 85 tgg cgc age gag agg ctt gcc gac gtc gtc gtc acc gct gt ttg ttg gga act 403 Trp Arg Ser Glu Arg Leu Wing Asp Val Leu Thr Wing Leu Leu Gly Thr 90 95 100 ggg ttt aaa ccc cgc ggc aaa cta tet gga tcg tcc acc ctg cca cg ggg 451 Gly Phe Lys Pro Arg Gly Lys Leu Ser Gly Be Phe Thr Leu Pro Gly 105 110 115 25 ca gct gg gg gg gg ggc gca cta ccc aat gaa etc att cgt tta 499 Gln Ala Val Asp Ala Gly Gly Ala Leu Pro Asn Glu Leu He Arg Leu 120 125 130 agt tea ggt gat ggc atg age gca ttt ggt gga gtt ttt gcc tcc ggt 547 Ser Ser Gly Asp Gly Met Ser Wing Phe Gly Gly Val Phe Wing Ser Gly 135 140 145 gtt cca acc act tta cgt acc gca gtg aaa age cat gtg cg gga gct 595 Val Pro Thr Thr Leu Arg Thr Wing Val Lys Ser His Val Pro Gly Wing 150 155 160 165 ggt cgc aat agg gag ccc gca tet falls ttt gtg gat ate acc aag ate 643• Gly Arg Asn Arg Glu Pro Wing His Phe Val Asp He Thr Lys He 170 175 180 tcg gag ect gtg gcc gtg gag cgt gaa gac etc ggc gag gct cag cgc 691 Ser Glu Pro Val Wing Val Glu Arg Glu Asp Leu Gly Glu Ala Gln Arg 185 190 195 cga gca gcg tcc ttt ttg ctt gac ggc gcc aaa gtt aaa gcc gga age 739 Arg Ala Ala Ser Phe Leu Leu Asp Gly Ala Lys Val Lys Ala Gly Ser 200 205 210 cat gtg ttg gag ttt ccc age agt ggt gga gct tta gct att ttg gct 787 His Val Leu Glu Phe Pro Ser Ser Gly Gly Wing Leu Wing He Leu Wing 215 220 225 10 gct cgc cgc cag gga act gtt gac gct tta acg gct gat ccc gcg ca 835 Wing Arg Arg Gln Gly Thr Val Asp Ala Leu Thr Ala Asp Pro Ala Gln 230 235 240 245 gtt tea age ctg gag gag acg ttt gtg etc gcc ggt gtg gag gag gat 883 • Val Ser Ser Leu Glu Glu Thr Phe Val Leu Wing Gly Val Glu Glu Asp 250 255 260 att falls ate gag gtc att ccc cag gcg att ccc tcg cca cgc gaa tgg 931 He His He Glu Val He Pro Gln Ala He Pro Ser Pro Arg Glu Trp 265 270 275 ggt ggc gcc tac gat tcg ata gtc gcc atg gag aag cta gaa gtg gtg 979 Gly Gly Wing Tyr Asp Ser He Val Wing Met Glu Lys Leu Glu Val Val 280 285 290 15 ggc aag falls ggt tcc aag cgg ttt att aaa gct ate gac aga atg etc 1027 Gly Lys His Gly Ser Lys Arg Phe He Lys Ala He Asp Arg Met Leu 295 300 305 acc acc ggc ggc aac gta gcc gcc atg cact tcc ttg gta gct act gac ca 1075 Thr Thr Gly Gly Asn Val Ala Met Gln Ser Leu Val Ala Thr Asp Gln 310 315 320 325 tgg agt ect gtg tgt tet gaa gcg att tet ttg etc aag gcc tat att 1123 Trp Ser Pro Val Cys Ser Glu Ala He Ser Leu Leu Lys Ala Tyr He 330 335 340 • tgg ect gcg ctg cat tac cca act gtt gat gaa gtt cat cag ctt gtt 1171 Trp Pro Ala Leu His Tyr Pro Thr Val Asp Glu Val His Gln Leu Val 345 350 355 20 gat agg gat tet tet ctg cgc gtg gtg aag gaa here falls ttt gcg ggc 1219 Asp Arg Asp Ser Ser Leu Arg Val Val Lys Glu Thr His Phe Wing Gly 360 365 370 cat tac cta aaa age gtg cag ttg caa cgt gaa gtg ttt gaa ggc cag 1267 His Tyr Leu Lys Ser Val Gln Leu Gln Arg Glu Val Phe Glu Gly Gln 375 380 385 ata cgc gaa gcg gcg gca gat ggc ttt gat gcc gtc tac cgc cgc atg 1315 He Arg Glu Wing Wing Wing Asp Gly Phe Asp Wing Val Tyr Arg Arg Met 390 395 400 405 tgg gtg tat fall tac gcg ctt att gaa gcc ctg tta cgc ctg gga tgt 1363 Trp Val Tyr His Tyr Ala Leu He Glu Ala Leu Leu Arg Leu Gly Cys 410 415 420 25 etc aat gca gtg cat ttt gcg ttg acg here aga aac aga agg ggg cgt 1411 Leu Asn Ala Val Gln Phe Ala Leu Thr Thr Arg Asn Arg Arg Gly Arg 425 430 435 cga taagcaaaaa tcttttagac etc 1437 Arg < 210 > 70 < 211 > 438 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 70 Met Ala Glu Ala Arg Leu Arg His Leu Glu Pro He Asp Val Glu Glu 1 5 10 15 Trp Pro Gly Val Ala Ser Val Pro Asn Leu Ala Phe Ala Gly Ala Arg 20 25 30 Ala Arg Gln Ala Glu Tyr Arg Phe Ala Lys Ala Cys Ser Asn Ala Gly 35 40 45 Leu Val Leu Leu Gly Asn Asp Pro Asp Leu He He Asp His Glu Glu 50 55 60 Leu Phe Ser Arg Leu Wing Wing Ser Gly Trp Leu Gly Leu Wing Glu Ser 65 70 75 80 Tyr Met Wing Gly Glu Trp Arg Ser Glu Arg Leu Wing Asp Val Leu Thr 85 90 95 Wing Leu Leu Gly Thr Gly Phe Lys Pro Arg Gly Lys Leu Ser Gly Ser 100 105 110 Phe Thr Leu Pro Gly Gln Wing Val Asp Wing Gly Gly Wing Leu Pro Asn 115 120 125 Glu Leu He Arg Leu Be Ser Gly Asp Gly Met Be Wing Phe Gly Gly 130 135 140 Val Phe Wing Ser Gly Val Pro Thr Thr Leu Arg Thr Wing Val Lys Ser 145 150 155 160 His Val Pro Gly Wing Gly Arg Asn Arg Glu Pro Wing Ser His Phe Val 165 170 175 Asp He Thr Lys He Ser Glu Pro Val Wing Val Glu Arg Glu Asp Leu 180 185 190 Gly Glu Wing Gln Arg Arg Wing Wing Being Phe Leu Leu Asp Gly Wing Lys 195 200 205 Val Lys Wing Gly Ser His Val Leu Glu Phe Pro Ser Ser Gly Gly Wing 210 215 220 Leu Wing He Leu Wing Wing Arg Arg Gln Gly Thr Val Asp Wing Leu Thr 225 230 235 240 Wing Asp Pro Wing Gln Val Ser Leu Glu Glu Thr Phe Val Leu Wing 245 250 255 Gly Val Glu Glu Asp He His He Glu Val He Pro Gln Ala He Pro 260 265 270 Ser Pro Arg Glu Trp Gly Gly Wing Tyr Asp Ser He Val Val Met Met Glu 275 2 80 285 Lys Leu Glu Val Val Gly Lys His Gly Ser Lys Arg Phe He Lys Wing 290 295 300 He Asp Arg Met Leu Thr Thr Gly Gly Asn Val Wing Met Gln Ser Leu 305 310 315 320 Val Wing Thr Asp Gln Trp Ser Pro Val Cys Ser Glu Ala He Ser Leu 325 330 335 Leu Lys Wing Tyr He Trp Pro Wing Leu His Tyr Pro Thr Val Asp Glu 340 345 350 Val His Gln Leu Val Asp Arg Asp Ser Ser Leu Arg Val Val Lys Glu 355 360 365 Thr His Phe Wing Gly His Tyr Leu Lys Ser Val Gln Leu Gln Arg Glu 370 375 380 Val Phe Glu Gly Gln He Arg Glu Wing Wing Asp Gly Phe Asp Wing 385 390 395 400 Val Tyr Arg Arg Met Trp Val Tyr His Tyr Ala Leu He Glu Ala Leu 405 410 415 Leu Arg Leu Gly Cys Leu Asn Wing Val Gln Phe Wing Leu Thr Thr Arg 420 425 430 Asn Arg Arg Gly Arg Arg 435 <; 210 > 71 < 211 > 1140 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1117) < 223 > RXA01801 < 400 > 71 tttlggattcc "tttccgatita tigtcttgatc gct? Cattctg tcat; atccgg <gttgtctaaa 60 caeecgcgaa igatttcctgt g¡atgtgccac actggttctc atg tet aac gta gtg 115 Met Ser Asn Val Val 1 5 aac act ttt gtc cag aat tcc acc ggt atg gtg gag ctt aat cgt ccc 163 Asn Thr Phe Val Gln Asn Ser Thr Gly Met Val Glu Leu Asn Arg Pro 10 15 20 aaa gcg etc aat tet ctt aat cag gaa atg ate gat etc gtt cag gaa 211 Lys Ala Leu Asn Ser Leu Asn Gln Glu Met He Asp Leu Val Gln Glu 25 30 35 gct cta acc act tgg gct gat gat gat gtg cag cag gtt etc att 259 Wing Leu Thr Thr Trp Wing Asp Asp Asp Gln Val Gln Gln Val Leu He 40 45 50 tac tea tcc tcg gag cgt gca ttt tgt gcc ggc ggt gat gtg cgc gcg 307 Tyr Ser Ser Glu Arg Wing Phe Cys Wing Gly Gly Asp Val Arg Wing 55 60 65 gtc cgt gag age gtg tg ggc gat gtt gcg gcc ggc gat aag tat 355 Val Arg Glu Ser Val Leu Glu Gly Asp Val Wing Wing Gly Asp Lys Tyr 70 75 80 85 ttc ate gat gag ttc gcg atg aac aac acg ttg gga acc tat ccg aag 403 Phe He Asp Glu Phe Wing Met Asn A sn Thr Leu Gly Thr Tyr Pro Lys 90 95 100 ccg gtc att tet gtg ate aac ggc gtc gcg atg ggt ggc gga atg gga 451 Pro Val He Ser Val He Asn Gly Val Wing Met Gly Gly Gly Met Gly 105 110 115 att tcc atg cat gga tcg falls cgg ate gtc acg gaa aaa gcg tcc gcg 499 He Ser Met His Gly Ser His Arg He Val Thr Glu Lys Wing Phe Wing 120 125 130 tcg atg ect gag atg gcg ate ggc tat gtt ccc gat gtg ggc ttt act 547 Ser Met Pro Glu Met Wing He Gly Tyr Val Pro Asp Val Gly Phe Thr 135 140 145 tat ttc ggt cag cgt gca tcg tcg ctg gcc ate gcc here ttt ttg gcg 595 Tyr Phe Gly Gln Arg Ala Ser Ser Leu Ala He Ala Thr Phe Leu Ala 150 155 160 165 > . ^ Aiák? ^ Jí gtg acc ggg tgg cgc atg age ect gcc gat atg ctg tgg gct ggc gtc 643 Val Thr Gly Trp Arg Met Ser Pro Wing Asp Met Leu Trp Wing Gly Val 170 175 180 gca acg cat ttt gtt gag gat gcg cag ggg ttc att gat gcg gtc ttg 691 Wing Thr His Phe Val Glu Asp Wing Gln Gly Phe He Asp Wing Val Leu 185 190 195 aac gag tcg ctt gat ggc gcg ctg gag aaa ttc tcc acg caa ect acg 739 Asn Glu Ser Leu Asp Gly Ala Leu Glu Lys Phe Ser Thr Gln Pro Thr • 200 205 210 ggc age age gag ctg gcg gcc gcc age cag att gag gag acc ttt 787 Gly Ser Ser Glu Leu Ala Gly Val Ala Ser Gln He Glu Glu Thr Phe 215 220 225 ggg falls age tet tgg gcg ctt ate gac gcc tcc etc cgg tet falls ccc 835 Gly His Ser Ser Trp Wing Leu He Asp Wing Ser Leu Arg Ser His Pro 230 235 240 245 gat gct gaa ttt gtt gcc aag gtg gat ggg ctg atg gcg tcg gca gca 883 Asp Wing Glu Phe Val Wing Lys Val Asp Gly Leu Met Wing Wing Wing 250 255 260 ccg gca tcg gtg gtg gct acc gtg aag ctg atg cat caa aac agt gag 931 Pro Ala Ser Val Val Ala Thr Val Lys Leu Met His Gln Asn Ser Glu 10 265 270 275 gcg acc act ctg cgt gaa ggc ttg gac aat gaa ttg gcg atg tet ctt 979 Wing Thr Thr Leu Arg Glu Gly Leu Asp Asn Glu Leu Wing Met Ser Leu • 280 285 290 tat atg ate cgc cag ect gat ttt gct ggt ggt ggg gg gg gg tgg 1027 Tyr Met He Arg Gln Pro Asp Phe Wing Glu Gly Val Arg Wing Val Leu 295 300 305 gtt gat aaa gac cgc aat gca gcc ttc ccc gcc aac tac gaa gat 1075 Val Asp Lys Asp Arg Asn Wing Wing Phe Ser Pro Wing Asn Tyr Glu Asp 310 315 320 325 gtt gat gag tea cat ttt gtg acc ttg ttc cag cgc agt tea 1117 Val Asp Glu Ser His Phe Val Thr Leu Phe Gln Arg Ser Ser 15 330 335 taaaaccgcc aaacttttga tag 1140 < 210 > 72 < 211 > 339 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 72 Met Ser Asn Val Val Asn Thr Phe Val Gln Asn Ser Thr Gly Met Val 1 5 10 15 Glu Leu Asn Arg Pro Lys Ala Leu Asn Ser Leu Asn Gln Glu Met He 20 20 25 30 Asp Leu Val Gln Glu Ala Leu Thr Thr Trp Wing Asp Asp Asp Gln Val 35 40 45 Gln Gln Val Leu He Tyr Ser Ser Glu Arg Wing Phe Cys Wing Gly 50 55 60 Gly Asp Val Arg Wing Val Arg Glu Ser Val Leu Glu Gly Asp Val Wing 65 70 75 80 Wing Gly Asp Lys Tyr Phe He Asp Glu Phe Wing Met Asn Asn Thr Leu 85 90 95 Gly Thr Tyr Pro Lys Pro Val He Ser Val He Asn Gly Val Wing Met 100 105 110 Gly Gly Gly Met Gly He Ser Met His Gly Ser His Arg He Val Thr 25 115 120 125 UJ ^ AJ ^ Á ^ Glu Lys Ala Phe Ala Ser Met Pro Glu Met Wing He Gly Tyr Val Pro 130 135 140 Asp Val Gly Phe Thr Tyr Phe Gly Gln Arg Ala Ser Ser Leu Ala He 145 150 155 160 Ala Thr Phe Leu Ala Val Thr Gly Trp Arg Met Ser Pro Wing Asp Met 165 170 175 Leu Trp Wing Gly Val Wing Thr His Phe Val Glu Asp Wing Gln Gly Phe 180 185 190 5 He Asp Wing Val Leu Asn Glu Ser Leu Asp Gly Wing Leu Glu Lys Phe 195 200 205 Ser Thr Gln Pro Thr Gly Ser Ser Glu Leu Wing Gly Val Wing Ser Gln 210 215 220 He Glu Glu Thr Phe Gly His Ser Ser Trp Ala Leu He Asp Ala Ser 225 230 235 240 Leu Arg Ser His Pro Asp Ala Glu Phe Val Wing Lys Val Asp Gly Leu 245 250 255 Met Wing Wing Wing Wing Pro Wing Val Val Wing Thr Val Lys Leu Met 260 265 270 His Gln Asn Ser Glu Wing Thr Thr Leu Arg Glu Gly Leu Asp Asn Glu 275 280 285 JQ Leu Ala Met Ser Leu Tyr Met He Arg Gln Pro Asp Phe Wing Glu Gly 290 295 300 Val Arg Wing Val Leu Val Asp Lys Asp Arg Asn Wing Wing Phe Ser Pro • 305 310 315 320 Wing Asn Tyr Glu Asp Val Asp Glu Ser Hi s Phe Val Thr Leu Phe Gln 325 330 335 Arg Ser Ser < 210 > 73 < 211 > 1086 < 212 > DNA < 213 > Corynebacterium glutamicum 15 < 220 > < 221 > CDS < 222 > (101) .. (1063) < 223 > RXN02512 < 400 > 73 gctggaaagt ccccattggc taaggaattt accaaggcac cagcaggtgc gaaggeagat 60 • tacageaaca ccaaataaaa attagccgag ggageatege atg aag ccg aag gat 115 Met Lys Pro Lys Asp 1 5 ttc tgc here gcg gaa aat tgg gcg gag aat tta age gca ctg ggc tat 163 2Q Phe Cys Thr Wing Glu Asn Trp Wing Glu Asn Leu Ser Wing Leu Gly Tyr 10 15 20 cta gct ggt tgg cgt ttt gtc cgg atg etc ect ttg ect att gct cgc 211 Leu Wing Gly Trp Arg Phe Val Arg Met Leu Pro Leu Pro He Wing Arg 25 30 35 cgg gtg ttt gac ctt ggg gcg gat ctg gcg tcg aaa age gga aaa ggc 259 Arg Val Phe Asp Leu Gly Wing Asp Leu Wing Ser Lys Ser Gly Lys Gly 40 45 50 atg ggg cag cta cgc gct aat ctg gcg cgg gtg gtc ggt gcg gaa aac 307 Met Gly Gln Leu Arg Ala Asn Leu Ala Arg Val Val Gly Ala Glu Asn 55 60 65 gtt acg cag gcg ctg gtg aag ca gca acg cgc age tat gcg cgg tat 355 25 Val Thr Gln Ala Leu Val Lys Gln Wing Thr Arg Ser Tyr Wing Arg Tyr 70 75 80 85 tgg ctg gaa gcg ttc cgg cta ccg gcg ate gcg cga gat ect gag ctg 403 Trp Leu Glu Wing Phe Arg Leu Pro Wing Wing Wing Arg Asp Pro Glu Leu 90 95 100 ctt gcg cgg ttg cgt aag gga act gtt ggc cta gat ttg ttg gat gaa 451 Leu Wing Arg Leu Arg Lys Gly Thr Val Gly Leu Asp Leu Leu Asp Glu 105 110 115 tet ttg gct gcc ggc aag ggc gta gtt ttg acg etc cca falls age ggc 499 Ser Leu Wing Wing Gly Lys Gly Val Val Leu Thr Leu Pro His Ser Gly 120 125 130 aac tgg gat atg gct gct gct gctc ctg att age c at cat ggg cat ttc 547 Asn Trp Asp Met Ala Gly Ala Phe Leu He Ser His His Gly Gln Phe 135 140 145 acc acc gtt gca gaa agg gtc aag ccg gaa cgc ttg ttt gaa gcg ttc 595 Thr Thr Val Ala Glu Arg Val Lys Pro Glu Arg Leu Phe Glu Wing Phe 150 155 160 165 gtg gag ttt cga gaga age ctt gga ttt gag gtg ctg ect etc acc ggt 643 Val Glu Phe Arg Glu Ser Leu Gly Phe Glu Val Leu Pro Leu Thr Gly 170 175 180 ggc gag cgt ccg ccg ttt gaa aag ctg aaa gag cgc ctg here tet gga 691 10 Gly Glu Arg Pro Pro Phe Glu Lys Leu Lys Glu Arg Leu Thr Ser Gly 185 190 195 ggt ate gtg tgc ctt ctt ggg gag cgt gac ctg cgg cat tcc ggc gtg 739 • Gly He Val Cys Leu Leu Gly Glu Arg Asp Leu Arg His Ser Gly Val 200 205 210 gag acc act ttt ttt ggt gag aag acc tcc atg cca gca gga ect gcg 787 Glu Thr Thr Phe Phe Gly Glu Lys Thr Ser Met Pro Wing Gly Pro Wing 215 220 225 cag ctg gcc att gaa here ggt gcg gcg ctg falls gtg gtg cat cca tgg 835 Gln Leu Ala He Glu Thr Gly Ala Ala Leu His Val Val His Pro Trp 230 235 240 245 ttc gat gac gac ggc tgg ggt etc age gta tcc gat gcc gtg acc gtg 15 Phe Asp Asp Asp Gly Trp Gly Leu Ser Val Ser Asp Wing Val Thr Val 250 255 260 gat aat tta tc gac acg gtg cag cgg ate gca cat ctt ttt atg gca 931 Asp Asn Leu Ser Asp Thr Val Gln Arg He Wing His Leu Phe Met Wing 265 270 275 aat att acg gcg falls ccc gct gat tgg cat atg etc ca ccc ctg tgg 979 Asn He Thr Wing His Pro Wing Asp Trp His Met Leu Gln Pro Leu Trp 280 285 290 • ttt ggt gat ttg gat ccg gag cgt etc aag cgc tet agg gag cag here 1027 Phe Gly Asp Leu Asp Pro Glu Arg Leu Lys Arg Ser Arg Glu Gln Thr 295 300 305 aat gtt falls aaa ccg gtg gca t ta cag gag gac aat taggtgcgaa 1073 20 Asn Val His Lys Pro Val Wing Leu Gln Glu Asp Asn 310 315 320 ttggaatggt ctg 1086 < 210 > 74 < 211 > 321 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 74 Met Lys Pro Lys Asp Phe Cys Thr Ala Glu Asn Trp Ala Glu Asn Leu 1 5 10 15 25 Be Ala Leu Gly Tyr Leu Ala Gly Trp Arg Phe Val Arg Met Leu Pro ¿An¿ * L ¿A k 20 25 30 Leu Pro He Wing Arg Arg Val Phe Asp Leu Gly Wing Asp Leu Wing Ser 35 40 45 Lys Ser Gly Lys Gly Met Gly Gln Leu Arg Wing Asn Leu Wing Arg Val 50 55 60 Val Gly Wing Glu Asn Val Thr Gln Wing Leu Val Lys Gln Wing Thr Arg 65 70 75 80 Ser Tyr Wing Arg Tyr Trp Leu Glu Wing Phe Arg Leu Pro Wing Wing 85 90 95 • Arg Asp Pro Glu Leu Leu Wing Arg Leu Arg Lys Gly Thr Val Gly Leu 100 105 110 Asp Leu Leu Asp Glu Be Leu Wing Wing Gly Lys Gly Val Val Leu Thr 115 120 125 Leu Pro His Ser Gly Asn Trp Asp Met Wing Gly Wing Phe Leu He Ser 130 135 140 His His Gly Gln Phe Thr Thr Val Wing Glu Arg Val Lys Pro Glu Arg 145 150 155 160 Leu Phe Glu Wing Phe Val Glu Phe Arg Glu Ser Leu Gly Phe Glu Val 165 170 175 Leu Pro Leu Thr Gly Gly Glu Arg Pro Pro Phe Glu Lys Leu Lys Glu 10 180 185 190 Arg Leu Thr Ser Gly Gly He Val Cys Leu Leu Gly Glu Arg Asp Leu 195 200 205 Arg His Ser Gly Val Glu Thr Thr Phe Phe Gly Glu Lys Thr Ser Met 210 215 220 Pro Ala Gly Pro Ala Gln Leu Ala He Gl u Thr Gly Ala Ala Leu His 225 230 235 240 Val Val His Pro Trp Phe Asp Asp Asp Gly Trp Gly Leu Ser Val Ser 245 250 255 Asp Wing Val Thr Val Asp Asn Leu Ser Asp Thr Val Gln Arg He Wing 260 265 270 His Leu Phe Met Wing Asn He Thr Wing His Pro Wing Asp Trp His Met 15 275 280 285 Leu Gln Pro Leu Trp Phe Gly Asp Leu Asp Pro Glu Arg Leu Lys Arg 290 295 300 Ser Arg Glu Gln Thr Asn Val His Lys Pro Val Wing Leu Gln Glu Asp 305 310 315 320 Asn < 210 > 75 < 211 > 1057 • < 212 > DNA < 213 > Corynebacterium glutamicum 20 < 220 > < 221 > CDS < 222 > (101) .. (1057) < 223 > FRXA02512 < 400 > 75 gctggaaagt ccccattggc taaggaattt accaaggcac cagcaggtgc gaaggeagat 60 tacageaaca ccaaataaaa attagccgag ggageatege atg aag ccg aag gat 115 Met Lys Pro Lys Asp 1 5 ttc tgc here gcg gaa aat tgg gcg gag aat tta age gca ctg ggc tat 163 Phe Cys Thr Ala Glu Asn Trp Ala Glu Asn Leu Be Wing Leu Gly Tyr 25 10 15 20 cta gct ggg tgg cgt ttt gtc cgg atg etc ect ttg ect att gct cgc 211 Leu Wing Gly Trp Arg Phe Val Arg Met Leu Pro Leu Pro He Wing Arg 25 30 35 cgg gtg ttt gac ctt ggg gcg gat ctg gcg tcg aaa age gga aaa ggc 259 Arg Val Phe Asp Leu Gly Wing Asp Leu Wing Ser Lys Ser Gly Lys Gly 40 45 50 atg ggg cag cta cgc gct aat ctg gcg cgg gtg gtc ggt gcg gaa aac 307 Met Gly Gln Leu Arg Wing Asn Leu Wing Arg Val Val Gly Wing Glu Asn • 55 60 65 gtt acg cag gcg ctg gtg aag ca gca acg cgc age tat gcg cgg tat 355 Val Thr Gln Ala Leu Val Lys Gln Ala Thr Arg Ser Tyr Wing Arg Tyr 70 75 80 85 tgg ctg gaa gcg tcc cgg cta ccg gcg ate gcg cga gat ect gag ctg 403 Trp Leu Glu Wing Phe Arg Leu Pro Wing Wing Wing Arg Asp Pro Glu Leu 90 95 100 ctt gcg cgg ttg cgt aag gga act gtt ggc cta gat ttg ttg gat gaa 451 Leu Wing Arg Leu Arg Lys Gly Thr Val Gly Leu Asp Leu Leu Asp Glu 105 110 115 tet ttg gct gcc ggc aag ggc gta gtt ttg acg etc cca drops age ggc 499 Be Leu Wing Wing Gly Lys Gly Val Val Leu Thr Leu Pro His Ser Gly 10 120 125 130 aac tgg gat atg gct ggc gct ttt ctg att age cat cat ggg cat ttc 547 Asn Trp Asp Met Wing Gly Wing Phe Leu He Ser His His Gly Gln Phe • 135 140 145 acc acc gtt gca gag agg gtc aag ccg gaa cgc ttg ttt gaa gcg ttc 595 Thr Thr Val Wing Glu Arg Val Lys Pro Glu Arg Leu Phe Glu Wing Phe 150 155 160 165 gtg gag ttt cga gaa age ctt gga ttt gag gtg ctg ect etc acc ggt 643 Val Glu Phe Arg Glu Ser Leu Gly Phe Glu Val Leu Pro Leu Thr Gly 170 175 180 ggc gag cgt ccg ctg ttt gaa aag ctg aaa gag cgc ctg here tet gga 691 Gly Glu Arg Pro Pro Phe Glu Lys Leu Lys Glu Arg Leu Thr Ser Gly 15 185 190 195 ggt ate gtg tgc ctt ctt ggg gag cgt gac ctg cgg cat tcc ggc gtg 739 Gly He Val Cys Leu Leu Gly Glu Arg Asp Leu Arg His Ser Gly Val 200 205 210 gag acc act ttt ggt gag aag acc tcc atg cca gca gga ect gcg 787 Glu Thr Thr Phe Phe Gly Glu Lys Thr Ser Met Pro Wing Gly Pro Wing 215 220 225 cag ctg gcc att gaa here ggt gcg gcg ctg falls gtg gtg cat cca tgg 835 Gln Leu Wing He Glu Thr Gly Wing Wing Leu His Val Val His Pro Trp 230 235 240 245 ttc gat gac gac ggc tgg ggt etc age gta tcc gat gcc gtg acc gtg 883 Phe Asp Asp Asp Gly Trp Gly Leu Ser Val Ser Asp Wing Val Thr Val 20 250 255 260 gat aat tta tc gac acg gtg cag cgg ate gca cat ctt ttt atg gca 931 Asp Asn Leu Ser Asp Thr Val Gln Arg He Wing His Leu Phe Met Wing 265 270 275 aat att acg gcg falls ccc gct gat tgg cat atg etc ca ccc ctg tgg 979 Asn He Thr Ala His Pro Wing Asp Trp His Met Leu Gln Pro Leu Trp 280 285 290 ttt ggt gat ttg gat ccg gag cg aag cgc tet agg gag cag here 1027 Phe Gly Asp Leu Asp Pro Glu Arg Leu Lys Arg Ser Arg Glu Gln Thr 295 300 305 aat gtt falls aaa ccg gtg gca tta cag gag 1057 Asn Val His Lys Pro Val Ala Leu Gln Glu 25 310 315 < 210 > 76 < 211 > 319 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 76 Met Lys Pro Lys Asp Phe Cys Thr Ala Glu Asn Trp Ala Glu Asn Leu 1 5 10 15 Be Ala Leu Gly Tyr Leu Ala Gly Trp Arg Phe Val Arg Met Leu Pro 20 25 30 Leu Pro He Ala Arg Arg Val Phe Asp Leu Gly Wing Asp Leu Wing Ser 35 40 45 Lys Ser Gly Lys Gly Met Gly Gln Leu Arg Wing Asn Leu Wing Arg Val 50 55 60 Val Gly Wing Glu Asn Val Thr Gln Wing Leu Val Lys Gln Wing Thr Arg 65 70 75 80 Ser Tyr Wing Arg Tyr Trp Leu Glu Wing Phe Arg Leu Pro Wing Wing 85 90 95 Arg Asp Pro Glu Leu Leu Wing Arg Leu Arg Lys Gly Thr Val Gly Leu 10 100 105 110 Asp Leu Leu Asp Glu Ser Leu Wing Wing Gly Lys Gly Val Val Leu Thr 115 120 125 Leu Pro His Ser Gly Asn Trp Asp Met Wing Gly Wing Phe Leu He Ser • 130 135 140 His His Gly Gln Phe Thr Thr Val Ala Glu Arg Val Lys Pro Glu Arg 145 150 155 160 Leu Phe Glu Ala Phe Val Glu Phe Arg Glu Ser Leu Gly Phe Glu Val 165 170 175 Leu Pro Leu Thr Gly Gly Glu Arg Pro Pro Phe Glu Lys Leu Lys Glu 180 185 190 Arg Leu Thr Ser Gly Gly He Val Cys Leu Leu Gly Glu Arg Asp Leu 15 195 200 205 Arg His Ser Gly Val Glu Thr Thr Phe Phe Gly Glu Lys Thr Ser Met 210 215 220 Pro Ala Gly Pro Ala Gln Leu Ala He Glu Thr Gly Ala Ala Leu His 225 230 235 240 Val Val His Pro Trp Phe Asp Asp Asp Gly Trp Gly Leu Ser Val Ser 245 250 255 Asp Wing Val Thr Val Asp Asn Leu Ser Asp Thr Val Gln Arg He Wing 260 265 270 • His Leu Phe Met Wing Asn He Thr Wing His Pro Wing Asp Trp His Met 275 280 285 Leu Gln Pro Leu Trp Phe Gly Asp Leu Asp Pro Glu Arg Leu Lys Arg 20 290 295 300 Ser Arg Glu Gln Thr Asn Val His Lys Pro Val Ala Leu Gln Glu 305 310 315 < 210 > 77 < 211 > 1389 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1366) 25 < 223 > RXA00899 < 400 > 77 tttgctgctc, cect, acgtieg gactcccact gttcctgctt atgggaticgc icatacatcaa 60 ccggtgaicgc icaccgcaticc aacaaigaaa't caacgacctc atg gaa gac gtc falls 115 Met Glu Asp Val His 1 5 gac gac gtc ccc gac ate ccc acc gga atg gat gtc tcc gcg gaa gtt 163 Asp Asp Val Pro Asp He Pro Thr Gly Met Asp Val Ser Wing Glu Val 10 15 20 gaa tet gtc ate aaa etc aac cgc cgc etc acc cgc atg cca gca gtg 211 Glu Ser Val He Lys Leu Asn Arg Arg Leu Thr Arg Met Pro Ala Val 25 30 35 acc ggc gga aac aac ggc ttc tac tc gac tac cgt gaa tcc etc aaa 259 Thr Gly Gly Asn Asn Gly Phe Tyr Ser Asp Tyr Arg Glu Ser Leu Lys 40 45 50 cgg atg acc gcc gca ate gac gaa gcc gaa gaa tac ate tac gtc gag 307 Arg Met Thr Wing Wing He Asp Glu Wing Glu Glu Tyr He Tyr Val Glu 55 60 65 ate tac ate atg gcc tgg gat tcc tac accca cca tcc tcc gca gca 355 He Tyr He Met Wing Trp Asp Ser Tyr Thr Gln Pro Phe Phe Wing Wing 10 70 75 80 85 etc gaa cga gcc falls aac cgc ggc gtc aaa gtc cga etc ctt ttc gac 403 Leu Glu Arg Ala His Asn Arg Gly Val Lys Val Arg Leu Leu Phe Asp • 90 95 100 fall gtc ggc age tgg aaa tac ccc ggc tac falls cgc etc aaa aaa gaa 451 His Val Gly Ser Trp Lys Tyr Pro Gly Tyr His Arg Leu Lys Lys Glu 105 110 115 aac etc cgc atg ggc ttc gcc tgg tac etc atg etc ccc etc cacc ccc 499 Leu Asn Arg Met Gly Phe Wing Trp Tyr Leu Met Leu Pro Leu Gln Pro 120 125 130 tgg cgc cgc cgc ttc cgc cga ccc gac ctg cgc aac cgc aaa falls atg 547 Trp Arg Arg Arg Phe Arg Arg Pro Asp Leu Arg Asn His Arg Lys Met 15 135 140 145 etc ate ate gac ggc falls acc gca ttc atg ggc tcc caat aat etc ate 595 Leu He He Asp Gly His Thr Wing Phe Met Gly Ser Gln Asn Leu He 150 155 160 165 gcc ccg agt tac cta caa aag aaa aac aa aa aa aa aa c aa aa aa aa aa aa ggc cgc gaa tgg 643 Pro Wing Pro Tyr Leu Gln Lys Lys Asn He Lys Leu Gly Arg Glu Trp 170 175 180 aaa gac etc atg gtc gaa etc acc ggc ccc ate gtc tcc tcc atg gaa 691 • Lys Asp Leu Met Val Glu Leu Thr Gly Pro He Val Ser Ser Met Glu 185 190 195 atg ate ttc gcc ggc gac tgg tac gtc gaa tcc aac gaa gcc etc gac 739 Met He Phe Wing Gly Asp Trp Tyr Val Glu Ser Asn Glu Wing Leu Asp 20 200 205 210 ate cgc gac cae gca gaa gcc falls ggc tac ate ggc aac act aaa 787 He Arg Asp His Wing Glu Wing His Gly Tyr He Gly Asn Thr Gln Lys 215 220 225 gac tcc gcc acc aac etc gtg cag etc ccc ccc tcc gct ect ggt tac 835 Asp Be Wing Thr Asn Leu Val Gln Leu He Pro Ser Gly Pro Gly Tyr 230 235 240 245 acc here gaa ccc aac ctg cgc atg ttc aac tcc ate gtt fall drops gcc 883 Thr Thr Glu Pro Asn Leu Arg Met Phe Asn Ser He Val His His Wing 250 255 260 aaa gaa cga etc ate ttg tgc age ccc tac tcc ate ccc gac gaa tcc 931 Lys Glu Arg Leu He Leu Cys Ser Pro Tyr Phe He Pro Asp Glu Ser 25 265 270 275 , ^ - * a > etc etc gaa gcc gtc acc tea gcc tgc tac cgc gga gta acc gtc gaa 979 Leu Leu Glu Wing Val Thr Ser Ala Cys Tyr Arg Gly Val Thr Val Glu 280 285 290 cta ttc gtc tet gaa ca gcc gac ca tc gcc ate gac cae gcc ca 1027 Leu Phe Val Ser Glu Gln Wing Asp Gln Phe Wing He Asp His Wing Gln 295 300 305 tcc tcc tac tac cag gca etc ctt gaa gcg ggc gtg aaa ate tac caa 1075 Ser Ser Tyr Tyr Gln Ala Leu Leu Glu Ala Gly Val Lys He Tyr Gln 310 • 315 320 325 tcc ccc aaa ccc gac gtc etc falls acc aag tac atg ate gcc gac ccc 1123 Phe Pro Lys Pro Asp Val Leu His Thr Lys Tyr Met He Wing Asp Pro 330 335 340 gac gac acc acc ggc aac gaa gcc ggc etc gga gtc etc gga tcc tcc aac 1171 Asp Asp Thr Thr Gly Asn Glu Wing Leu Gly Val Leu Gly Ser Ser Asn 345 350 355 etc gac ate cgc age ttt ggc etc aac tac gaa ate tcc ctg atg ate 1219 Leu Asp He Arg Being Phe Gly Leu Asn Tyr Glu He Being Leu Met He 360 365 370 gcc aaa ggc aac etc tie falls gaa etc aac gcc etc acc gac cgt tac 1267 Wing Lys Gly Asn Leu He His Glu Leu A sn Ala Leu Thr Asp Arg Tyr 10 375 380 385 cgc here gta agt ttc aag etc acc ttg gat aag tgg aac cag cgc agt 1315 Arg Thr Val Ser Phe Lys Leu Thr Leu Asp Lys Trp Asn Gln Arg Ser 390 395 400 405 tgg cgg cgc cgc tac gtg gac aat gtc atg cgt ttg acc tcg gcg ctg 1363 Trp Arg Arg Arg Tyr Val Asp Asn Val Met Arg Leu Thr Ser Ala Leu 410 415 420 cag tagtttggcg cgtttggagt gcg 1389 Gln < 210 > 78 15 < 211 > 422 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 78 Met Glu Asp Val Asp Asp Val Pro Asp He Pro Thr Gly Met Asp 1 5 10 15 Val Ser Wing Glu Val Glu Ser Val He Lys Leu Asn Arg Arg Leu Thr • 20 25 30 Arg Met Pro Wing Val Thr Gly Gly Asn Asn Gly Phe Tyr Ser Asp Tyr 35 40 45 Arg Glu Be Leu Lys Arg Met Thr Wing Wing He Asp Glu Wing Glu Glu 20 50 55 60 Tyr He Tyr Val Glu He Tyr He Met Wing Trp Asp Ser Tyr Thr Gln 65 70 75 80 Pro Phe Ala Ala Ala Leu Glu Arg Ala His Asn Arg Gly Val Lys Val 85 90 95 Arg Leu Leu Phe Asp His Val Gly Ser Trp Lys Tyr Pro Gly Tyr His 100 105 110 Arg Leu Lys Lys Glu Leu Asn Arg Met Gly Phe Ala Trp Tyr Leu Met 115 120 125 Leu Pro Leu Gln Pro Trp Arg Arg Arg Phe Arg Arg Pro Asp Leu Arg 130 135 140 Asn His Arg Lys Met Leu He He Asp Gly His Thr Ala Phe Met Gly 25 145 150 155 160 Being Gln Asn Leu He Wing Pro Being Tyr Leu Gln Lys Lys Asn He Lys 165 170 175 Leu Gly Arg Glu Trp Lys Asp Leu Met Val Glu Leu Thr Gly Pro He 180 185 190 Val Ser Ser Met Glu Met He Phe Wing Gly Asp Trp Tyr Val Glu Ser 195 200 205 Asn Glu Ala Leu Asp He Arg Asp His Wing Glu Wing His Gly Tyr He 210 215 220 Gly Asn Thr Gln Lys Asp Ser Wing Thr Asn Leu Val Gln Leu He Pro 225 230 235 240 Ser Gly Pro Gly Tyr Thr Thr Glu Pro Asn Leu Arg Met Phe Asn Ser 245 250 255 He Val His His Wing Lys Glu Arg Leu He Leu Cys Ser Pro Tyr Phe 260 265 270 He Pro Asp Glu Ser Leu Leu Glu Wing Val Thr Ser Wing Cys Tyr Arg 275 280 285 Gly Val Thr Val Glu Leu Phe Val Ser Glu Gln Wing Asp Gln Phe Wing 290 295 300 He Asp His Wing Gln Ser Ser Tyr Tyr Gln Wing Leu Leu Glu Wing Gly 305 310 315 320 10 Val Lys He Tyr Gln Phe Pro Lys Pro Asp Val Leu His Thr Lys Tyr 325 330 335 Met He Wing Asp Pro Asp Asp Thr Thr Gly Asn Glu Wing Leu Gly Val • 340 345 350 Leu Gly Being Ser Asn Leu Asp He Arg Being Phe Gly Leu Asn Tyr Glu 355 360 365 I've Been Leu Met He Wing Lys Gly Asn Leu He His Glu Leu Asn Wing 370 375 380 Leu Thr Asp Arg Tyr Arg Thr Val Be Phe Lys Leu Thr Leu Asp Lys 385 390 395 400 Trp Asn Gln Arg Ser Trp Arg Arg Arg Tyr Val Asp Asn Val Met Arg 405 410 415 15 Leu Thr Ser Ala Leu Gln 420 < 210 > 79 < 211 > 1452 < 212 > DNA < 213 > Corynebacterium glutamicum • < 220 > < 221 > CDS < 222 > (101) .. (1429) < 223 > RXN00819 20 < 220 > < 221 > misc_feature < 222 > 1264 < 223 > n indicates any nucleotide < 220 > < 221 > misc_feature < 222 > 1267 < 223 > n indicates any nucleotide < 220 > 25 < 221 > mise feature < 222 > 1268 < 223 > n indicates any nucleotide < 220 > < 221 > mise feature < 222 > 1279 < 223 > n indicates any nucleotide < 220 > < 221 > mise feature < 222 > 1281 < 223 > n indicates any nucleotide < 220 > < 221 > mise feature < 222 > 1285 < 223 > n indicates any nucleotide < 220 > < 221 > mise feature 10 < 222 > 1301 < 223 > n indicates any nucleotide • < 220 > < 221 > misc_feature < 222 > 1304 < 223 > n indicates any nucleotide < 220 > < 221 > VARIANT < 222 > 390 < 223 > Xaa = Ser, Pro, Thr, or Ala 15 < 220 > < 221 > VARIANT < 222 > 394 < 223 > Xaa = Leu, Pro, His, or Arg < 220 > < 221 > VARIANT • < 222 > 401 < 223 > Xaa = Tyr, His, Asn, or Asp < 220 > 20 < 221 > VARIANT < 222 > 402 < 223 > Xaa = Ser, Pro, Thr, or Ala < 400 > 79 gatgaggttc gtccgggaat cctcaaagac aatgcggtga aggtacttgg cctagccgct 60 agcactgagc gcggatctca agcagaaaag gtcgtgcaac atg cgt gat ccc att 115 Met Arg Asp Pro He 1 5 ca ggt gct gtt att ect tet gat ctt ttt ggt ttc gca gaa gtt etc 163 Gln Gly Ala Val He Pro Ser Asp Leu Phe Gly Phe Wing Glu Val Leu 10 15 20 25 acc gaa gcc gaa cgc gca gtt ctt ctg gaa acc cgc agg gtg ctt gag 211 Thr Glu Wing Glu Arg Wing Val Leu Leu Glu Thr Arg Arg Val Leu Glu 25 30 35 gaa gag gtg aag ect tat att aat gag gcc tgg gat aag gca gtc ttc 259 Glu Glu Val Lys Pro Tyr He Asn Glu Wing Trp Asp Lys Wing Val Phe 40 45 50 ccc gat gag ate gtg cag ccc etc ca hat gat ctg cat ttg ctt gat ccg 307 Pro Asp Glu He Val Gln Pro Leu Gln Asp Leu Gln Leu Leu Asp Pro 55 60 65 ect gca ctt cgg gaa gca ggg gag tcg gtt cga gac att ttc act ggt 355 Pro Ala Leu Arg Glu Wing Gly Glu Ser Val Arg Asp He Phe Thr Gly 70 75 80 85 ttc cgc aat ttt gaa etc gcg cgc tgt gac ate aat gtt ggt acc tat 403 Phe Arg Asn Phe Glu Leu Wing Arg Cys Asp He Asn Val Gly Thr Tyr 90 95 100 tac aac gca tet gct ggt etc ttc cga acg gcc tgc atg gtt ggt ggc 451 Tyr Asn Wing Be Wing Gly Leu Phe Arg Thr Wing Cys Met Val Gly Gly 105 110 115 tcc ccg gag cag gcg cag cga ttg gat gcg cag ate aaa tet ggt gag 499 Ser Pro Glu Gln Wing Gln Arg Leu Asp Wing Gln He Lys Ser Gly Glu 120 125 130 10 gtc aag ggc gtt ttt gca ctg acg gaa ect gat cat ggc tet gat ate 547 Val Lys Gly Val Phe Ala Leu Thr Glu Pro Asp His Gly Ser Asp He 135 140 145 • gca ggt ggt ctg gca acc acg gcc act aag gac gac acc ggc gag 595 Wing Gly Gly Leu Wing Thr Thr Wing Thr Lys Asp Wing Asp Thr Gly Glu 150 155 160 165 tgg att ate aat ggt gaa aaa cgg tgg ate ggt ggt gct tct act gct 643 Trp He He Asn Gly Glu Lys Arg Trp He Gly Gly Ala Ser Thr Ala 170 175 180 gat ttg ate gct acc ttc gcc agg gat here gcc gat aac cag gtg aaa 691 Asp Leu He Wing Thr Phe Wing Arg Asp Thr Wing Asp Asn Gln Val Lys 185 190 195 15 tgc ttc etc gtg gca ect cag gca gag ggc gtg tcc atg gag att att 739 Cys Phe Leu Val Wing Pro Gln Wing Glu Gly Val Ser Met Glu He He 200 205 210 gat cgc aaa gcc tea ctg c ate at g ca aat gca falls att ata 787 Asp Arg Lys Ala Ser Leu Arg He Met Gln Asn Ala His He Thr Tyr 215 220 225 aac aat gtc cgg gtg tet ggg gat gcg cgg ctg falls aac ate aat tet 835 Asn Asn Val Arg Val Ser Gly Asp Ala Arg Leu His Asn He Asn Ser • 230 235 240 245 ttc aag gat gtt tcg gaa tgc ctg cgc cgt atg cgt tcc gat gtg gcg 883 Phe Lys Asp Val Ser Glu Cys Leu Arg Arg Met Arg Ser Asp Val Ala 250 255 260 20 tgg atg gcg gtc ggt gcg cag gca ggt gcc tat gaa gca gcc gtg aag 931 Trp Met Wing Val Gly Wing Gln Wing Gly Wing Tyr Glu Wing Wing Val Lys 265 270 275 tat gtg cgc age agg gaa cag ttt ggc cgc ccg ate gcg ggg ttc cag 979 Tyr Val Arg Ser Arg Glu Gln Phe Gly Arg Pro He Wing Gly Phe Gln 280 285 290 ttg att cag gaa aag etc gcg etc atg ctg ggc aat etc acg gcg tcg 1027 Leu He Gln Glu Lys Leu Ala Leu Met Leu Gly Asn Leu Thr Ala Ser 295 300 305 ctg ggc atg atg gtc aaa etc acc gat cag cag ggg gga att ttc 1075 Leu Gly Met Met Val Lys Leu Thr Asp Gln Gln Gln Wing Gly He Phe 310 315 320 325 25 aaa gag gaa aac tcc gcg ctg gcg aaa atg ttt acc tcg etc aaa ctt 1123 Lys Glu Glu Asn Be Ala Leu Ala Lys Met Phe Thr Ser Leu Lys Leu 330 335 340 cgg gag acc gct agt tgg gcg cgg gaa ate tgc gga ggc aac ggc ate 1171 Arg Glu Thr Wing Ser Trp Wing Arg Glu He Cys Gly Gl and Asn Gly He 345 350 355 att ttg gac aac gat gtt gcc cgg ttc cat gcc gat gca gaa gcc gtc 1219 He Leu Asp Asn Asp Val Wing Arg Phe His Wing Asp Wing Glu Wing Val 360 365 370 tat tea tat gaa ggc acc falls gaa ate aat gca etc ate gtt ggn cgn 1267 • Tyr Ser Tyr Glu Gly Thr His Glu He Asn Ala Leu He Val Gly Arg 375 380 385 nec att ctg ggn cnt ethn ttc ttt tta tat tat nac nct ttt gag gag 1315 Xaa He Leu Gly Xaa Leu Phe Phe Leu Tyr Tyr Xaa Xaa Phe Glu Glu 390 395 400 405 gat ctt cat gac tac tc c falls ccc aaa cca tcg ttt ttt ctt tcg aag 1363 Asp Leu His Asp Tyr Phe His Pro Lys Pro Ser Phe Leu Ser Lys 410 415 420 acg falls cca ccc tea ccg gcc agg acc tgg gct ttt cgc agt ggc gca 1411 Thr His Gln Pro Ser Pro Wing Arg Thr Trp Wing Phe Arg Ser Gly Wing 425 430 435 ctg tea ccc agg aga tgg tgaacacctt ggcggacgca act 1452 10 Leu Ser Pro Arg Arg Trp 440 • < 210 > 80 < 211 > 443 < 212 > PRT < 213 > Corynebacterium glutamicum < 220 > < 221 > VARIANT < 222 > 390 15 < 223 > Xaa = Ser, Pro, Thr, or Ala < 220 > < 221 > VARIANT < 222 > 394 < 223 > Xaa = Leu, Pro, His, or Arg < 220 > < 221 > VARIANT • < 222 > 401 < 223 > Xaa = Tyr, His, Asn, or Asp 20 < 220 > < 221 > VARIANT < 222 > 402 < 223 > Xaa = Ser, Pro, Thr, or Ala < 400 > 80 Met Arg Asp Pro He Gln Gly Ala Val He Pro Ser Asp Leu Phe Gly 1 5 10 15 Phe Ala Glu Val Leu Thr Glu Ala Glu Arg Ala Val Leu Leu Glu Thr 20 25 30 Arg Arg Val Leu Glu Glu Val Val Lys Pro Tyr He Asn Glu Wing Trp 35 40 45 25 Asp Lys Wing Val Phe Pro Asp Glu He Val Gln Pro Leu Gln Asp Leu 50 55 60 Gln Leu Leu Asp Pro Pro Wing Leu Arg Glu Wing Gly Glu Ser Val Arg 65 70 75 80 Asp He Phe Thr Gly Phe Arg Asn Phe Glu Leu Wing Arg Cys Asp He 85 90 95 Asn Val Gly Thr Tyr Tyr Asn Wing Be Wing Gly Leu Phe Arg Thr Wing 100 105 110 Cys Met Val Gly Gly Ser Pro Glu Gln Wing Gln Arg Leu Asp Ala Gln 115 120 125 He Lys Ser Gly Glu Val Lys Gly Val Phe Ala Leu Thr Glu Pro Asp 130 135 140 His Gly Ser Asp He Wing Gly Gly Leu Wing Thr Thr Wing Thr Lys Asp 145 150 155 160 Wing Asp Thr Gly Glu Trp He He Asn Gly Glu Lys Arg Trp He Gly 165 170 175 Gly Wing Being Thr Wing Asp Leu Wing Wing Thr Phe Wing Arg Asp Thr Wing 180 185 190 Asp Asn Gln Val Lys Cys Phe Leu Val Wing Pro Gln Wing Glu Gly Val 195 200 205 Ser Met Glu He He Asp Arg Lys Wing Ser Leu Arg He Met Gln Asn 210 215 220 Wing His He Thr Tyr Asn Asn Val Arg Val Ser Gly Asp Wing Arg Leu 225 230 235 240 His Asn He Asn Ser Phe Lys Asp Val Ser Glu Cys Leu Arg Arg Met 245 250 255 Arg Ser Asp Val Ala Trp Met Ala Val Gly Ala Gln Ala Gly Ala Tyr 260 265 270 Glu Ala Ala Val Lys Tyr Val Arg Ser Arg Glu Gln Phe Gly Arg Pro 275 280 285 He Wing Gly Phe Gln Leu He Gln Glu Lys Leu Wing Leu Met Leu Gly 290 295 300 Asn Leu Thr Wing Being Leu Gly Met Met Val Lys Leu Thr Asp Gln Gln 305 310 315 320 Gln Ala Gly He Phe Lys Glu Glu Asn Ser Ala Leu Ala Lys Met Phe 325 330 335 Thr Ser Leu Lys Leu Arg Glu Thr Wing Ser Trp Wing Arg Glu He Cys 340 345 350 Gly Gly Asn Gly He He Leu Asp Asn Asp Val Wing Arg Phe His Wing 355 360 365 Asp Ala Glu Ala Val Tyr Ser Tyr Glu Gly Thr His Glu He Asn Wing 370 375 380 Leu He Val Gly Arg Xaa He Leu Gly Xaa Leu Phe Phe Leu Tyr Tyr 385 390 395 400 Xaa Xaa Phe Glu Glu Asp Leu His Asp Tyr Phe His His Pro Lys Pro 405 410 415 Be Phe Leu Ser Lys Thr His Gln Pro Ser Pro Wing Arg Thr Trp Wing 420 425 430 Phe Arg Ser Gly Wing Leu Ser Pro Arg Arg Trp 435 440 < 210 > 81 < 211 > 1030 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS aát.¿ ... < 222 > (18) .. (1007) < 223 > FRXA00819 < 220 > < 221 > misc_feature < 222 > 842 < 223 > n indicates any nucleotide • < 220 > < 221 > misc_feature < 222 > 845 < 223 > n indicates any nucleotide < 220 > < 221 > misc_feature < 222 > 846 < 223 > n indicates any nucleotide < 220 > < 221 > misc_feature 10 < 222 > 857 < 223 > n indicates any nucleotide < 220 > < 221 > m? sc_feature < 222 > 859 < 223 > n indicates any nucleotide < 220 > < 221 > misc_feature < 222 > 863 < 223 > n indicates any nucleotide 15 <; 220 > < 221 > misc_feature < 222 > 879 < 223 > n indicates any nucleotide < 220 > < 221 > misc_feature • < 222 > 882 < 223 > n indicates any nucleotide < 220 > 20 < 221 > VARIANT < 222 > 277 < 223 > Xaa = Ser, Pro, Thr, or Ala < 220 > < 221 > VARIANT < 222 > 281 < 223 > Xaa = Leu, Pro, His, or Arg < 220 > < 221 > VARIANT < 222 > 288 25 < 223 > Xaa = Tyr, His, Asn, or Asp í: rá..í? .1, i. t í- 4..4? . *., & l.t ^, < 220 > < 221 > VARIANT < 222 > 289 < 223 > Xaa = Ser, Pro, Thr, or Ala < 400 > 81 tcttccgaac ggcctgc atg gtt ggt ggc tcc ccg gag cag gcg cag cga 50 • Met Val Gly Gly Ser Pro Glu Gln Ala Gln Arg 1 5 10 ttg gat gcg cag ate aa tet ggt gag gtc aag ggc gtt ttt gca ctg 98 Leu Asp Ala Gln He Lys Ser Gly Glu Val Lys Gly Val Phe Ala Leu 15 20 25 acg gaa ect gat cat ggc tet gat ate gca ggt ggt ctg gca acc acg 146 Thr Glu Pro Asp His Gly Ser Asp He Wing Gly Gly Leu Wing Thr Thr 30 35 40 gcc act aag gac gca gac acc ggc gag tgg att ate aat ggt gaa aaa 194 Wing Thr Lys Asp Wing Asp Thr Gly Glu Trp He He Asn Gly Glu Lys 45 50 55 cgg tgg ate ggt ggt gct gct tct act gct gat ttg ate gct acc ttc gcc 242 10 Arg Trp He Gly Gly Wing Being Thr Wing Asp Leu He Wing Thr Phe Wing 60 65 70 75 agg gat here gcc gat aac cag gtg aaa tgc ttc etc gtg gca ect cag 290 • Arg Asp Thr Wing Asp Asn Gln Val Lys Cys Phe Leu Val Wing Pro Gln 80 85 90 gca gag ggc gtg tcc atg gag att att gat cgc aaa gcc tea ctg cgc 338 Wing Glu Gly Val Ser Met Glu He He Asp Arg Lys Ala Ser Leu Arg 95 100 105 ate atg caa aat gca falls att ata tat aac aat gtc cgg gtg tet ggg 386 He Met Gln Asn Ala His He Thr Tyr Asn Asn Val Arg Val Ser Gly 110 115 120 gat gcg cgg ctg falls aac ate aat tet ttc aag gat gtt tcg gaa tgc 434 j <; Asp Ala Arg Leu His Asn He Asn Ser Phe Lys Asp Val Ser Glu Cys 125 130 135 ctc cgc cgt atg cgt tcc gat gtg gcg tgg atg gcg gtc ggt gcg cag 482 Leu Arg Arg Met Arg Ser Asp Val Wing Trp Met Wing Val Gly Wing Gln 140 145 150 155 gca ggt gcc tat gaa gcc gcg gtg aag tat gtg cgc age agg gaa cag 530 Wing Gly Wing Tyr Glu Wing Wing Val Lys Tyr Val Arg Ser Arg Glu Gln 160 165 170 ttt ggc cgt ccg ate gcg ggg ttc cag ttg att cag gaa aag etc gcg 578 Phe Gly Arg Pro He Wing Gly Phe Gln Leu He Gln Glu Lys Leu Wing 175 180 185 etc atg ctg ggc aat etc acg gcg tcg ctg ggc atg atg gtc aaa etc 626 20 Leu Met Leu Gly Asn Leu Thr Wing Being Leu Gly Met Met Val Lys Leu 190 195 200 acc gat cag cag gcg gga att ttc aaa gag gaa aac tcc gcg ctg 674 Thr Asp Gln Gln Gln Wing Gly He Phe Lys Glu Glu Asn Ser Wing Leu 205 210 215 gcg aaa atg ttt acc tcg etc aaa ctt cgg gag acc gct agt tgg gcg 722 Wing Lys Met Phe Thr Ser Leu Lys Leu Arg Glu Thr Ala Ser Trp Wing 220 225 230 235 cgg gaa ate tgc gga ggc aac ggc at e att ttg gac aac gat gtt gcc 770 Arg Glu He Cys Gly Gly Asn Gly He He Leu Asp Asn Asp Val Wing 240 245 250 cgg ttc cat gcc gat gca gaa gcc gtc tat tea tat gaa ggc acc fall 818 25 Arg Phe His Wing Asp Ala Glu Ala Val Tyr Ser Tyr Glu Gly Thr His 255 260 265 gaa ate aat gca etc gtt ggn cgn nec att ctg ggn cnt etn ttc 866 Glu He Asn Ala Leu He Val Gly Arg Xaa He Leu Gly Xaa Leu Phe 270 275 280 ttt tta tat tat nac nct ttt gag gag gat ctt cat gac tac ttc falls 914 Phe Leu Tyr Tyr Xaa Xaa Phe Glu Glu Asp Leu His Asp Tyr Phe His 285 290 295 falls ccc aaa cca tcg ttt ctt tcg aag acg falls cca ccc tea ccg gcc 962 His Pro Lys Pro Ser Phe Leu Ser Lys Thr His Gln Pro Ser Wing • 300 305 310 315 agg acc tgg gct ttt cgc agt ggc gca ctg tea ccc agg aga tgg 1007 Arg Thr Trp Wing Phe Arg Ser Gly Wing Leu Ser Pro Arg Arg Trp 320 325 330 tgaacacctt cgcggacgca act 1030 < 210 > 82 < 211 > 330 < 212 > PRT < 213 > Corynebacterium glutamicum < 220 > 10 < 221 > VARIANT < 222 > 277 < 223 > Xaa = Ser, Pro, Thr, or Ala • < 220 > < 221 > VARIANT < 222 > 281 < 223 > Xaa = Leu, Pro, His, or Arg < 220 > < 221 > VARIANT < 222 > 288 15 < 223 > Xaa = Tyr, His, Asn, or Asp < 220 > < 221 > VARIANT < 222 > 289 < 223 > Xaa = Ser, Pro, Thr, or Ala < 400 > 82 Met Val Gly Gly Ser Pro Glu Gln Ala Gln Arg Leu Asp Ala Gln He 1 5 10 15 Lys Ser Gly Glu Val Lys Gly Val Phe Ala Leu Thr Glu Pro Asp His 20 20 25 30 Gly Ser Asp He Ala Gly Gly Leu Ala Thr Thr Wing Thr Lys Asp Wing 35 40 45 Asp Thr Gly, Glu Trp He He Asn Gly Glu Lys Arg Trp He Gly Gly 50 55 60 Wing Be Thr Wing Asp Leu He Wing Thr Phe Wing Arg Asp Thr Wing Asp 65 70 75 80 Asn Gln Val Lys Cys Phe Leu Val Wing Pro Gln Wing Glu Gly Val Ser 85 90 95 Met Glu He He Asp Arg Lys Wing Being Leu Arg He Met Gln Asn Wing 100 105 110 His He Thr Tyr Asn Asn Val Arg Val Ser Gly Asp Wing Arg Leu His 25 115 120 125 Asn He Asn Ser Phe Lys Asp Val Ser Glu Cys Leu Arg Arg Met Arg 130 135 140 Ser Asp Val Wing Trp Met Wing Val Gly Wing Gln Wing Gly Wing Tyr Glu 145 150 155 160 Wing Wing Val Lys Tyr Val Arg Ser Arg Glu Gln Phe Gly Arg Pro He 165 170 175 Wing Gly Phe Gln Leu He Gln Glu Lys Leu Wing Leu Met Leu Gly Asn 180 185 190 • Leu Thr Wing Being Leu Gly Met Met Val Lys Leu Thr Asp Gln Gln Gln 195 200 205 Wing Gly He Phe Lys Glu Glu Asn Ser Wing Leu Wing Lys Met Phe Thr 210 215 220 Ser Leu Lys Leu Arg Glu Thr Wing Ser Trp Wing Arg Glu He Cys Gly 225 230 235 240 Gly Asn Gly He He Leu Asp Asn Asp Val Wing Arg Phe His Wing Asp 245 250 255 Wing Glu Wing Val Tyr Ser Tyr Glu Gly Th r His Glu He Asn Ala Leu 260 265 270 He Val Gly Arg Xaa He Leu Gly Xaa Leu Phe Phe Leu Tyr Tyr Xaa 275 280 285 10 Xaa Phe Glu Glu Asp Leu His Asp Tyr Phe His His Pro Lys Pro Ser 290 295 300 Phe Leu Ser Lys Thr His Gln Pro Pro Pro Wing Arg Thr Trp Wing Phe • 305 310 315 320 Arg Ser Gly Wing Leu Ser Pro Arg Arg Trp 325 330 <; 210 > 83 < 211 > 391 < 212 > DNA < 213 > Corynebacterium glutamicum 15 < 220 > < 221 > CDS < 222 > (101) .. (391) < 223 > FRXA01766 < 400 > 83 gat < gagglbtc < gtcegggaat cc; tcaaagac aa1; gcgcjtga aggi; act1: gg cctagccg, age; actgagc < gcggatctca agcagaaaag gtcgtgcaac atg cgt gat ccc att 115 Met Arg Asp Pro He 1 5 ca ggt gct gtt att ect tet gat ctt ttt ggt ttc gca gaa gtt etc 163 Gln Gly Ala Val He Pro Ser Asp Leu Phe Gly Phe Ala Glu Val Leu 20 10 15 20 acc gaa gcc gaa cgc gca gtt ctt ctg gaa acc cgc agg gtg ctt gag 211 Thr Glu Wing Glu Arg Wing Val Leu Leu Glu Thr Arg Arg Val Leu Glu 25 30 35 gaa gag gtg aag ect tat att aat gag gcc tgg gat aag gca gtc ttc 259 Glu Glu Val Lys Pro Tyr He Asn Glu Wing Trp Asp Lys Wing Val Phe 40 45 50 ccc gat gag ate gtg cag ccc etc ca hat gat ctg cat ttg ctt gat ccg 307 Pro Asp Glu He Val Gln Pro Leu Gln Asp Leu Gln Leu Leu Asp Pro 55 60 65 ect gca ctt cgg ga gca ggg gag tcg gtt cga gac att ttc act ggt 355 Pro Ala Leu Arg Glu Ala Gly Glu Ser Val Arg Asp He Phe Thr Gly 25 70 75 80 85 ttc cgc aat ttt gaa etc gcg cgc tgt gac ate aat 391 Phe Arg Asn Phe Glu Leu Wing Arg Cys Asp He Asn 90 95 < 210 > 84 < 211 > 97 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 84 Met Arg Asp Pro He Gln Gly Ala Val He Pro Ser Asp Leu Phe Gly January 5 10 15 Phe Ala Glu Val Leu Thr Glu Ala Glu Arg Ala Val Leu Leu Glu Thr 20 25 30 Arg Arg Val Leu Glu Glu Glu Val Lys Pro Tyr He Asn Glu Ala Trp 35 40 45 Asp Lys Ala Val Phe Pro Asp Glu He Val Gln Pro Leu Gln Asp Leu 50 55 60 Gln Leu Leu Asp Pro Pro Ala Leu Arg Glu Ala Gly Glu Ser Val Arg 65 70 75 80 Asp He Phe Thr Gly Phe Arg Asn Phe Glu Leu Wing Arg Cys Asp He 85 90 95 Asn < 210 > 85 < 211 > 1659 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1636) < 223 > RXN01762 < 400 > 85 tggagtg; atg; aattttccta tagaacgttt tttaaat? Gat tgacttttta aacgtttacg 60 cttttaatga < atg aaa cttcaaaccgt gatetaaage acaaaggaga gtg aac etc 115 Met Lys Asn Leu Val ata gga gga May 1 cca cga cgc age tac agg gca act gtt cca cga gag aka 163 Gly He Gly Ser Tyr Pro Arg Arg Arg Ala Thr Val Arg Pro Glu Ser 10 15 20 act gca ate gaa ttc gaa ggc acc age ate acc tac gga gaa ttc age 211 Thr Wing He Glu Phe Glu Gly Thr Ser He Thr Tyr Gly Glu Phe Ser 25 30 35 aaa cga gtc aat cgg gtt cat gct ctt cta gac etc ggc gtt gcg 259 Val Lys Arg Asn Arg Leu Leu Leu Ala Gl'y His Asp Gly Val Leu Ala 40 45 50 gat caa gta cga falls gct gtc tat ttc gga gcc aac ctg cta falls ect 307 His Gln Asp Arg Val Wing Tyr Val Gly Phe Asn His Pro Wing Leu Leu 55 60 65 gaa gtg ttc ttt tea acg aac etc. att ggg gca here ccc gtg ctt gtt 355 Glu Val Phe Phe Ser Thr Asn Leu He Gly Ala Thr Pro Val Leu Val 70 75 80 85 aac ect cctc cta tcg gca aac gaa ate gat tac ate ate caa gac age 403 Asn Pro Arg Leu Be Wing Asn Glu He Asp Tyr He He Gln Asp Ser 90 95 100 j ^ i ^^^^ ^^^^^^^ 'gcg ggt g ^^ age gtg ate ttt gga tac gac ate gcc etc ate gag falls Ala Ser Gly act 451 Phe Tyr Gly Val He He Asp Glu Leu He His Ala Thr 105 110 115 tac etc caa gaa etc cat cca gag ate ate atg gtg gcc gtt gaa ggc 499 Tyr Leu Gln Glu Leu His Pro Glu He He Met Met Val Wing Val Glu Gly 120 125 130 gat gag ggt cca ggt ttg cgt cga aaa gcg ctt att gaa gcg gcg age 547 Asp Glu Gly Pro Gly Leu Arg Arg Lys Wing Leu He Glu Wing Wing • 135 140 145 gac gcc gac ate gac cta gaa gtc age gat gat gac ctg gtg ctg etc 595 Asp Wing Asp He Asp Leu Glu Val Ser Asp Asp Asp Leu Val Leu Leu 150 155 160 165 atg tac acc aka gga acc act ggc cgc cca aag ggc gcc atg tta aka 643 Met Tyr Thr Ser Gly Thr Thr Gly Arg Pro Lys Gly Ala Met Leu Ser 170 175 180 falls cga aac etc ttc ttt aac tac ttc aat gcc ctg etc age cag gaa 691 His Arg Asn Leu Phe Phe Asn Tyr Phe Asn Ala Leu Leu Ser Gln Glu 185 190 195 att gaa ca ggc gcg gta ctt tta tcc tc ccg tta tc tc falls down 739 He Glu Gln Gly Wing Val L eu Leu Ser Thr Wing Pro Leu Phe His He 10 200 205 210 gcg ggc etc aac atg acc acc ate ccg gtg atg atg aag ggc gga aga 787 Wing Gly Leu Asn Met Thr Thr He Pro Val Met Met Lys Gly Gly Lys • 215 220 225 gtg ate ate drops cgc gaa ttc cgg gca gag drops gtc etc gac gaa ate 835 Val He He His Arg Glu Phe Arg Ala Glu His Val Leu Asp Glu He 230 235 240 245 gaa cgc tcc aag gta tcc gaa tcc ttc atg gtg cca gcg atg ate gac 883 Glu Arg Ser Lys Val Ser Glu Ser Phe Met Val Pro Ala Met He Asp 250 255 260 atg ttg tcc aac falls cca tea ttt gcc gaa cgc gac ctt tet tcc ctt 931 Met Leu Ser Asn His Pro Ser Phe Wing Glu Arg Asp Leu Ser Ser Leu 15 265 270 275 cgc gcc ate atg gtg ggc ggc tet ccc ctt age gaa cgt gcg ctg cga 979 Arg Wing He Met Val Gly Gly Ser Pro Leu Ser Glu Arg Ala Leu Arg 280 285 290 ate tgg ca gga cgc gac gta aaa att gtc ca ggc ttc ggc atg here 1027 He Trp Gln Gly Arg Asp Val Lys He Val Gln Gly Phe Gly Met Thr 295 300 305 gaa acc gca ccg ggc gcc tgt ate etc gag gca here gac here age 1075 Glu Thr Wing Pro Gly Wing Cys He Leu Glu Wing Thr Asp Thr Ser Thr 310 315 320 325 c ae ctt gga acc gca ggt cga gcc falls ttc ttc acc gac ate aaa cta 1123 His Leu Gly Thr Wing Gly Arg Wing His Phe Phe Thr Asp He Lys Leu 20 330 335 340 gtg gac ccg aaa acc ggc gaa gaa gtc ccc acc gga gag gcc ggc gaa 1171 Val Asp Pro Lys Thr Gly Glu Glu Val Pro Thr Gly Glu Wing Gly Glu 345 350 355 gtt etc cgc cgc gga cca cat gtg atg acc gga tac tgg aac cga cca cca 1219 Val Leu He Arg Gly Pro His Val Met Thr Gly Tyr Trp Asn Arg Pro 360 365 370 gaa gac acc gcc age gca cta caa aat ggc tgg tac falls tcc gga gat 1267 Glu Asp Thr Ala Be Ala Leu Gln Asn Gly Trp Tyr His Ser Gly Asp 375 380 385 ate gcc ate aaa gat gaa gac ggc tac tac acc ate aaa gac cgc ate 1315 He Ala He Lys Asp Glu Asp Gly Tyr Tyr Thr He Lys Asp Arg He 25 390 395 400 405 g¡j¡¡¡¡aaa gac atg tac ate tcc ggc ggc gaa aac att tac ccc gca gaa gtc 1363 Lys Asp Met Tyr He Ser Gly Glu Glu Asn He Tyr Pro Wing Glu Val 410 415 420 gaa ca gca etc cag gaa ctg gaa gca gtc ctt gat gcc gca gtc ate 1411 Glu Gln Ala Leu Gln Glu Leu Glu Ala Val Leu Asp Ala Ala Val He 425 430 435 gga gtc ccc gat gaa cga tgg ggc gaa act ggc ate gcc ttt gtc tcc 1459 Gly Val Pro Asp Glu Arg Trp Gly Glu Thr Gly He Ala Phe Val Ser • 440 445 450 ate cga gaa age tac ctg acc aac cca cca acc gga ccg gaa cta cga 1507 He Arg Glu Ser Tyr Leu Thr Asn Pro Pro Thr Gly Pro Glu Leu Arg 455 460 465 gaa cta cta ggc agt gtc cta gcc aga tac aaa ctt cca cga cga gaa ate 1555 Glu Leu Leu Gly Ser Val Leu Wing Arg Tyr Lys Leu Pro Arg Glu He 470 475 480 485 falls ate ate gaa gaa etc ccc cgc aac gcc here ggc aaa ate caa aag 1603 His He He Glu Glu Leu Pro Arg Asn Wing Thr Gly Lys He Gln Lys 490 495 500 aac ate ctg cga gac ttc acc ate ccc gtt te taaacccccc aacgtcactt 1656 Asn He Leu Arg Asp Phe Thr He Pro Val Ser 10 505 510 tga 1659 < 210 > 8 (5 • <211> 512 <212> PRT <213> Corynebacterium glutamicum <400> 86 Met Lys Val Asn Leu Gly He Gly Ser Tyr Pro Arg Arg Arg Ala Thr 1 5 10 15 Val Arg Pro Glu Ser Thr Wing He Glu Phe Glu Gly Thr Ser He Thr 15 20 25 30 Tyr Gly Glu Phe Ser Lys Arg Val Asn Arg Leu Gly His Wing Leu Leu 35 40 45 Asp Leu Gly Val Wing His Gln Asp Arg Val Wing Tyr Val Gly Phe Asn 50 55 60 His Pro Wing Leu Leu Glu Val Phe Phe Ser Thr Asn Leu He Gly Wing 65 70 75 80 Thr Pro Val Leu Val Asn Pro Arg Leu Ser Wing Asn Glu He Asp Tyr • 85 90 95 He He Gln Asp Ser Gly Ala Ser He Val Phe Tyr Gly He Asp Leu 100 105 110 He Glu His Wing Thr Tyr Leu Gln Glu Leu His Pro Glu He He Met 20 115 120 125 Val Wing Val Glu Gly Asp Glu Gly Pro Gly Leu Arg Arg Lys Ala Leu 130 135 140 He Glu Wing Wing Asp Wing Asp He Asp Leu Glu Val Ser Asp Asp 145 150 155 160 Asp Leu Val Leu Leu Met Tyr Thr Ser Gly Thr Thr Gly Arg Pro Lys 165 170 175 Gly Wing Met Leu Ser His Arg Asn Leu Phe Phe Asn Tyr Phe Asn Wing 180 185 190 Leu Leu Ser Gln Glu He Glu Gln Gly Wing Val Leu Leu Ser Thr Wing 195 200 205 Pro Leu Phe His He Wing Gly Leu Asn Met Thr Thr He Pro Val Met 25 210 215 220 Met Lys Gly Gly Lys Val He He His Arg Glu Phe Arg Ala Glu His 225 230 235 240 Val Leu Asp Glu He Glu Arg Ser Lys Val Ser Glu Ser Phe Met Val 245 250 255 Pro Wing Met He Asp Met Leu Ser Asn His Pro Ser Phe Wing Glu Arg 260 265 270 Asp Leu Ser Ser Leu Arg Ala He Met Val Gly Gly Ser Pro Leu Ser 275 280 285 Glu Arg Ala Leu Arg He Trp Gln Gly Arg Asp Val Lys He Val Gln 290 295 300 Gly Phe Gly Met Thr Glu Thr Ala Pro Gly Ala Cys He Leu Glu Ala 305 310 315 320 Thr Asp Thr Ser Thr His Leu Gly Thr Wing Gly Arg Wing His Phe Phe 325 330 335 Thr Asp He Lys Leu Val Asp Pro Lys Thr Gly Glu Glu Val Pro Thr 340 345 350 Gly Glu Wing Gly Glu Val Leu He Arg Gly Pro His Val Met Thr Gly 355 360 365 Tyr Trp Asn Arg Pro Glu Asp Thr Wing Being Wing Leu Gln Asn Gly Trp 370 375 380 Tyr His Ser Gly Asp He Wing He Lys Asp Glu Asp Gly Tyr Tyr Thr 385 390 395 400 He Lys Asp Arg He Lys Asp Met Tyr He Ser Gly Gly Glu Asn He 405 410 415 Tyr Pro Wing Glu Val Glu Gln Wing Leu Gln Glu Leu Glu Wing Val Leu 420 425 430 Asp Wing Wing Val He Gly Val Pro Asp Glu Arg Trp Gly Glu Thr Gly 435 440 445 He Wing Phe Val Ser He Arg Glu Ser Tyr Leu Thr Asn Pro Pro Thr 450 455 460 Gly Pro Glu Leu Arg Glu Leu Leu Gly Ser Val Leu Wing Arg Tyr Lys 465 470 475 480 Leu Pro Arg Glu He His He He Glu Glu Leu Pro Arg Asn Wing Thr 485 490 495 Gly Lys He Gln Lys Asn He Leu Arg Asp Phe Thr He Pro Val Ser 500 505 510 < 210 > 87 < 211 > 1372 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1363) < 223 > FRXA01762 < 400 > 87 tggagtgatg aattttccta tagaacgttt tttaaacgat tgacttttta aaegtttaeg 60 cttttaatga cttcaaacgt gatctaaagc acaaaggaga atg aaa gtg aac etc 115 Met Lys Val Asn Leu 1 5 gga ata gga age tac cca cga cgc agg gca act gtt cga cca gag tcc 163 Gly He Gly Ser Tyr Pro Arg Arg Arg Ala Thr Val Arg Pro Glu Ser 10 15 20 act gca ate gaa ttc gaa ggc acc age ate acc tac gga gaa ttc age 211 Thr Wing He Glu Phe Glu Gly Thr Ser He Thr Tyr Gly Glu Phe Ser 25 30 35 aaa cga gtc aat cgg ctt gga cat gct ctt cta gac etc ggc gtt gcg 259 Lys Arg Val Asn Arg Leu Gly His Ala Leu Leu Asp Leu Gly Val Ala 40 45 50 falls cat gat gga gta tat gtc gga ttc aac falls ect gcc ctg cta 307 His Gln Asp Arg Val Wing Tyr Val Gly Phe Asn His Pro Wing Leu Leu 55 60 65 gaa gtg ttc ttt tea acg aac etc att ggg gca here ccc gtg ctt gtt 355 Glu Val Phe Phe Ser Thr Asn Leu He Gly Wing Thr Pro Val Leu Val 70 75 80 85 aac ect cgc cta tcg gca aac gaa ate gat tac ate ate caa gac age 403 Asn Pro Arg Leu Ser Wing Asn Glu He Asp Tyr He He Gln Asp Ser 90 95 100 ggt gcg age ate gtg ttt tac gga ate gac etc ate gag drops gcc act 451 Gly Wing Be He Val Phe Tyr Gly He Asp Leu He Glu His Wing Thr 105 110 115 tac etc caa gaa etc cat cca gag ate ate atg gtg gcc gtt gaa ggc 499 Tyr Leu Gln Glu Leu His Pro Glu He He Met Met Val Wing Val Glu Gly 120 125 130 gat gag ggt cca ggt ttg cgt cga aaa gcg ctt att gaa gcg gc g age 547 10 Asp Glu Pro Gly Leu Arg Arg Lys Ala Leu He Glu Ala Ala Ser 135 140 145 gac gcc gac ate gac cta gaa gtc age gat gat gac ctg gtg ctg etc 595 • Asp Wing Asp He Asp Leu Glu Val Asp Asp Asp Leu Val Leu Leu 150 155 160 165 atg tac acc tcc gga acc act ggc cgc cca aag ggc gcc atg tta tcc 643 Met Tyr Thr Ser Gly Thr Thr Gly Arg Pro Lys Gly Wing Met Leu Ser 170 175 180 falls cga aac etc ttc ttt aac tac ttc aat gcc ctg etc age cag gaa 691 His Arg Asn Leu Phe Phe Asn Tyr Phe Asn Wing Leu Leu Ser Gln Glu 185 190 195 att gaa ca ggc gcg gta cta tta tcc act gcg ccg tta ttc ccaaee aattee 739 15 He Glu Gln Gly Wing Val Leu Leu Ser Thr Wing Pro Leu Phe His He 200 205 210 gcg ggc etc aac atg acc ate ccg gtg atg atg aag ggc ggggaa aaaagg 787 Wing Gly Leu Asn Met Thr Thr He Pro Val Met Met Lys Gly Gly Lys 215 220 225 gtg ate ate falls cgc gaa ttc cgg gca gag falls gtc etc gac gaa ate 835 Val He He His Arg Glu Phe Arg Ala Glu His Val Leu Asp Glu He 230 235 240 245 • gaa cgc tcc aag gta tcc gaa tcc ttc atg gtg cca gcg atg ate gac 883 Glu Arg Ser Lys Val Ser Glu Ser Phe Met Val Pro Ala Met He Asp 250 255 260 atg ttg tcc aac falls cca tea ttt gcc gaa cgc gac ctt tet tcc ctt 931 20 Met Leu Ser Asn His Pro Ser Phe Wing Glu Arg Asp Leu Ser Ser Leu 265 270 275 cgc gcc ate atg gtg ggc ggc tet ccc ctt age gaa cgt gcg ctg cga 979 Arg Ala He Met Val Gly Gly Ser Pro Leu Ser Glu Arg Ala Leu Arg 280 285 290 ate tgg ca gga cgc gac gta aaa att gtc ca ggc ttc ggc atg here 1027 He Trp Gln Gly Arg Asp Val Lys He Val Gln Gly Phe Gly Met Thr 295 300 305 gaa acc gca ccg ggc gcc tgt ate etc gag gca here gac here age 1075 Glu Thr Wing Pro Gly Wing Cys He Leu Glu Wing Thr Asp Thr Ser Thr 310 315 320 325 falls ctt gga acc gca ggt cga gcc falls ttc ttc acc gac ate aaa cta 1123 25 His Leu Gly Thr Wing Gly Arg Wing His Phe Phe Thr Asp He Lys Leu 330 335 340 gtg gac ccg aaa acc ggc gaa gtc ccc acc gga gag gcc ggc gaa 1171 Val Asp Pro Lys Thr Gly Glu Glu Val Pro Thr Gly Glu Wing Gly Glu 345 350 355 gtt etc ate cgc gga cca cat gtg atg acc gga tac tgg aac cga cca 1219 Val Leu He Arg Gly Pro His Val Met Thr Gly Tyr Trp Asn Arg Pro 360 365 370 gaa gac acc gcc age gca cta caa aat ggc tgg tac falls tcc gga gat 1267 • Glu Asp Thr Ala Be Ala Leu Gln Asn Gly Trp Tyr His Ser Gly Asp 375 380 385 ate gcc ate aaa gat gaa gac ggc tac tac acc ate aaa gac cgc ate 1315 He Ala He Lys Asp Glu Asp Gly Tyr Tyr Thr He Lys Asp Arg He 390 395 400 405 aaa gac atg tac ate tcc ggc ggc gaa aac att tac ccc gca gaa gtc 1363 Lys Asp Met Tyr He Ser Gly Glu Glu Asn He Tyr Pro Wing Glu Val 410 415 420 taagtaccc 1372 < 210 > 88 < 211 > 421 10 < 212 > PRT < 213 > Corynebacterium glutamicum • < 400 > 88 Met Lys Val Asn Leu Gly He Gly Ser Tyr Pro Arg Arg Arg Wing Thr 1 5 10 15 Val Arg Pro Glu Ser Thr Ala He Glu Phe Glu Gly Thr Ser He Thr 20 25 30 Tyr Gly Glu Phe Ser Lys Arg Val Asn Arg Leu Gly His Wing Leu Leu 35 40 45 Asp Leu Gly Val Wing His Gln Asp Arg Val Wing Tyr Val Gly Phe Asn 50 55 60 15 His Pro Wing Leu Leu Glu Val Phe Phe Ser Thr Asn Leu He Gly Wing 65 70 75 80 Thr Pro Val Leu Val Asn Pro Arg Leu Ser Wing Asn Glu He Asp Tyr 85 90 95 He He Gln Asp Ser Gly Ala Ser He Val Phe Tyr Gly He Asp Leu 100 105 110 He Glu His Wing Thr Tyr Leu Gln Glu Leu His Pro Glu He He Met 115 120 125 Val Wing Val Glu Gly Asp Glu Pro Gly Leu Arg Arg Lys Ala Leu 130 135 140 He Glu Ala Wing As Asp Wing Asp He Asp Leu Glu Val Ser Asp Asp 145 150 155 160 20 Asp Leu Val Leu Leu Met Tyr Thr Ser Gly Thr Thr Gly Arg Pro Lys 165 170 175 Gly Wing Met Leu Ser His Arg Asn Leu Phe Phe Asn Tyr Phe Asn Wing 180 185 190 Leu Leu Ser Gln Glu He Glu Gln Gly Wing Val Leu Leu Ser Thr Wing 195 200 205 Pro Leu Phe His He Wing Gly Leu Asn Met Thr Thr He Pro Val Met 210 215 220 Met Lys Gly Gly Lys Val He He His Arg Glu P he Arg Ala Glu His 225 230 235 240 Val Leu Asp Glu He Glu Arg Ser Lys Val Ser Glu Ser Phe Met Val 245 250 255 25 Pro Ala Met He Asp Met Leu Ser Asn His Pro Ser Phe Ala Glu Arg .tjj rt 4. X t "j._», 260 265 270 Asp Leu Ser Ser Leu Arg Ala He Met Val Gly Gly Ser Pro Leu Ser 275 280 285 Glu Arg Ala Leu Arg He Trp Gln Gly Arg Asp Val Lys He Val Gln 290 295 300 Gly Phe Gly Met Thr Glu Thr Wing Pro Gly Wing Cys He Leu Glu Wing 305 310 315 320 Thr Asp Thr Ser Thr His Leu Gly Thr Wing Gly Arg Wing His Phe Phe 325 330 335 • Thr Asp He Lys Leu Val Asp Pro Lys Thr Gly Glu Glu Val Pro Thr 340 345 350 Gly Glu Wing Gly Glu Val Leu He Arg Gly Pro His Val Met Thr Gly 355 360 365 Tyr Trp Asn Arg Pro Glu Asp Thr Ala Ser Ala Leu Gln Asn Gly Trp 370 375 380 Tyr His Ser Gly Asp He Wing He Lys Asp Glu Asp Gly Tyr Tyr Thr 385 390 395 400 He Lys Asp Arg He Lys Asp Met Tyr He Ser Gly Gly Glu Asn He 405 410 415 Tyr Pro Wing Glu Val 10 420 < 210 > 89 < 211 > 867 • < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (844) < 223 > RXA00681 15 < 400 > 89 aagggcaagg -ttgtcattgt ttgatecagat gcgccacgca tegaagg; acc <; ggcgcgcac 60 agccatgcgc actcagtatge atgcacatggg gtggat; acac atg ect agt cca cgc 115 Met Pro Ser Pro Arg 1 5 act gtt ctt ate act ggt gcc gct ggc ggt tgg cgg gca ttc gct 163 Thr Val Leu He Thr Gly Ala Gly Gly Wing Leu Gly Arg Ala Phe Wing 10 15 20 gaa ggt ttc gca gcc ca gga gac cgt ate gcg gtg gcg gat ate aat 211 Glu Gly Phe Wing Wing Gln Gly Asp Arg He Wing Val Wing Asp He Asn 25 30 35 ctg gat ggg gcg ca gag acc gtt gac aag ctg aaa gca ttg ggc gca 259 20 Leu Asp Gly Wing Gln Glu Thr Val Asp Lys Leu Lys Wing Ala Leu Gly Wing 40 45 50 gat gcc gca gcc ttt gaa gtt gat gtc acg tet ttg gag tcc acc gag 307 Asp Wing Wing Wing Phe Glu Val Asp Val Thr Ser Leu Glu Ser Thr Glu 55 60 65 gcc cta gcc gcc ggt gcc gct gag ttt ggc ggt ggc cga att gat gtc 355 Ala Leu Ala Ala Gly Ala Ala Glu Phe Gly Gly Gly Arg He Asp Val 70 75 80 85 ctt att aat aac gca gcg ata tat gcg here gtg act cgt tea ccg ttt 403 Leu He Asn Asn Ala Wing He Tyr Wing Thr Val Thr Arg Ser Pro Phe 90 95 100 gag gat att gac ect gcg gag tgg gat ttg gtc atg gga gtc aat etc 451 25 Glu Asp He Asp Pro Wing Glu Trp Asp Leu Val Met Gly Val Asn Leu 105 110 115 aaa ggc ccg tgg ttg gtg acg cgt tet gtg agt ccg ttt ttg tcc gat 499 Lys Gly Pro Trp Leu Val Thr Arg Ser Val Ser Pro Phe Leu Ser Asp 120 125 130 aat gcc cgt gtg gtc aat ctt tcc age gcg act gtg ttt tea gga tet 547 Asn Ala Arg Val Val Asn Leu Ser Ser Ala Thr Val Phe Ser Gly Ser 135 140 145 gca falls tgg gcg falls tac gtg gca tcc aaa ggt ggg gtc att gct tta 595 • Wing His Trp Wing His Tyr Val Wing Ser Lys Gly Gly Val He Wing Leu 150 155 160 165 acc agg gtg ctt gct aaa gag ctg ggt ggt cgt ggg ate acg gtc aat 643 Thr Arg Val Leu Wing Lys Glu Leu Gly Gly Arg Gly He Thr Val Asn 170 175 180 gcg gtt gcg ect ggg ttt acg ctg act gc age ttg gga etc atg 691 Wing Val Wing Pro Gly Phe Thr Leu Thr Glu Wing Ser Leu Gly Leu Met 185 190 195 gat age gcg gaa acg tac ggt gtc gat cgc gga tcc ate aag cgc gca 739 Asp Ser Wing Glu Thr Tyr Gly Val Asp Arg Gly Ser He Lys Arg Wing 200 205 210 age cac ccg aaa gac ate gtc ggc acc acc atg ttt ctt gca tcc cca 787 10 Ser Gln Pro Lys Asp He Val Gly Thr Thr Met Phe Leu Wing Ser Pro 215 220 225 gaa gcc gaa tac ate act ggg caa here etc gtt gat ggt ggc cga 835 • Glu Ala Glu Tyr He Thr Gly Gln Thr Leu He Val Asp Gly Gly Arg 230 235 240 245 cag ttc ate taagtactaa aagttctaaig gag 867 Gln Phe He < 210 > 9C) < 211 > 248 < 212 > PRT 15 < 213 > Ccirynebact: erium gl .utamicupi < 400 > 90 Met Pro Pro Pro Arg Thr Val Leu He Thr Gly Wing Wing Gly Gly Leu 1 5 10 15 Gly Arg Wing Phe Wing Glu Wing Gly Wing Wing Gln Gly Asp Arg Wing Wing 20 25 30 Val Wing Asp He Asn Leu Asp Gly Wing Gln Glu Thr Val Asp Lys Leu 35 40 45 Lys Ala Leu Gly Ala Asp Ala Ala Ala Phe Glu Val Asp Val Thr Ser 50 55 60 Leu Glu Ser Thr Glu Ala Leu Ala Ala Gly Ala Ala Glu Phe Gly Gly 20 65 70 75 80 Gly Arg He Asp Val Leu He Asn Asn Wing Wing He Tyr Wing Thr Val 85 90 95 Thr Arg Ser Pro Phe Glu Asp He Asp Pro Ala Glu Trp Asp Leu Val 100 105 110 Met Gly Val Asn Leu Lys Gly Pro Trp Leu Val Thr Arg Ser Val Ser 115 120 125 Pro Phe Leu Ser Asp Asn Ala Arg Val Val Asn Leu Ser Ser Ala Thr 130 135 140 Val Phe Being Gly Being Wing His Trp Wing His Tyr Val Wing Being Lys Gly 145 150 155 160 Gly Val He Wing Leu Thr Arg Val Leu Wing Lys Glu Leu Gly Gly Arg 25 165 170 175 Gly He Thr Val Asn Wing Val Wing Pro Gly Phe Thr Leu Thr Glu Wing 180 185 190 Ser Leu Gly Leu Met Asp Ser Wing Glu Thr Tyr Gly Val Asp Arg Gly 195 200 205 Ser He Lys Arg Ala Ser Gln Pro Lys Asp He Val Gly Thr Thr Met 210 215 220 Phe Leu Ala Ser Pro Glu Ala Glu Tyr He Thr Gly Gln Thr Leu He 225 230 235 240 Val Asp Gly Gly Arg Gln Phe He • 245 <; 210 > 91 < 211 > 837 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (814) < 223 > RXA00802 10 < 400 > 91 gccatggtga tcacaceaigt gtgggggctg aggctccaca ctt < ggaggaa -tggaittaaac 60 gcgggcacta, agccccgaac gattaigtagg ctitggg'cace atg gat ctt aaa ctt 115 • Met Asp Leu Lys Leu 1 5 ggt ggc ca gtc ata ctt gtt gtt ggc ggt gca gga act att ggt tet 163 Gly Gly Gln Val He Leu Val Val Gly Gly Wing Gly Thr He Gly Ser 10 15 20 gaa gtt gta aaa etc tta act gaa gag ggc gca acc gcg gta gcg gcg 211 Glu Val Val Lys Leu Leu Thr Glu Glu Gly Ala Thr Ala Val Wing Ala 25 30 35 15 tcg aga age acg ccc tta tet att gac gct tcg gat gaa gcg tcc gtc 259 Ser Arg Ser Thr Pro Leu Ser He Asp Wing Ser Asp Glu Wing Ser Val 40 45 50 cgt gcg ggc att gat cag gtg ate gca gaa cat ggt cgc ctg gat ggg 307 Arg Wing Gly He Asp Gln Val He Wing Glu His Gly Arg Leu Asp Gly 55 60 65 ctg gtt gtt tet tet gca ccc gcg gcg cag acg etc age gcg gag here 355 Leu Val Val Ser Ser Ala Pro Wing Ala Gln Thr Leu Ser Wing Glu Thr 70 75 80 85 • gca gat gat ccg gac act gtg ttg gct gct att gaa ggc aaa gcc ate 403 Wing Asp Asp Pro Asp Thr Val Leu Wing Wing He Glu Gly Lys Wing He 90 95 100 2 0 acg ttt atg aag gct gca acc gtg gcg etc gag aag atg cgt gag gct 451 Thr Phe Met Lys Ala Wing Thr Val Wing Leu Glu Lys Met Arg Glu Wing 105 110 115 gga cat ggg cgc ate gtt gca ctt tcc ggc atg aac tea tac aaa here 499 Gly His Gly Arg He Val Ala Leu Ser Gly Met Asn Ser Tyr Lys Thr 120 125 130 ttg agt act act gcg tcg gcg cga aat gct gcg ctg aat gtc gtg gtg 547 Leu Ser Thr Thr Ala Ser Ala Arg Asn Ala Ala Leu Asn Val Val Val 135 140 145 aaa aat ttg gcg gat cgt falls gcg ggc acc gga att gta aat gcg 595 Lys Asn Leu Wing Asp Arg His Wing Gly Thr Gly He Thr Val Asn Wing 150 155 160 165 25 att age ccg gga ttc gtg gta gct gag cca gac gct gag gta aac cgc 643 t »A -.t:« t ri? a L r?.? i? 4.... . . . aMriteaaa ^ He Ser Pro Gly Phe Val Val Wing Glu Pro Asp Wing Glu Val Asn Arg 170 175 180 gca aat ggt gac acc acg tgg agg agg tcg cgg agg cga tcg cgt ttt 691 Wing Asn Gly Asp Thr Thr Trp Arg Arg Ser Arg Arg Arg Ser Arg Phe 185 190 195 tgt tgt cgc cgc gca ccg cat cat ttt ctg gag aga tta ttt cgg tgg 739 Cys Cys Arg Arg Ala Pro His Gln Phe Leu Glu Arg Leu Phe Arg Trp 200 205 210 gac ata agg cga agg gca tea tcc ttc ctt age tcg cgt gag ctt ccc 787 Asp He Arg Arg Arg Wing Being Ser Phe Leu Ser Ser Arg Glu Leu Pro 215 220 225 aag cgt aag falls ccc cgt gtg agg gca taacggccgt tctgttaaag 834 Lys Arg Lys His Pro Arg Val Arg Ala 230 235 att 837 < 210 > 92 < 211 > 238 < 212 > PRT < 213 > Corynebacterium glutamicum 10 < 400 > 92 Met Asp Leu Lys Leu Gly Gly Gln Val He Leu Val Val Gly Gly Wing 1 5 10 15 Gly Thr He Gly Ser Glu Val Val Lys Leu Leu Thr Glu Glu Gly Wing 20 25 30 Thr Wing Ala Wing Wing Ser Arg Ser Thr Pro Leu Ser He Asp Wing Ser 35 40 45 Asp Glu Wing Ser Val Arg Wing Gly He Asp Gln Val He Wing Glu His 50 55 60 Gly Arg Leu Asp Gly Leu Val Val Ser Wing Pro Wing Wing Gln Thr 65 70 75 80 J5 Leu Ser Wing Glu Thr Wing Asp Asp Pro Asp Thr Val Leu Wing Wing 85 90 95 Glu Gly Lys Wing He Thr Phe Met Lys Wing Wing Thr Val Wing Ala Leu Glu 100 105 110 Lys Met Arg Glu Wing Gly His Gly Arg He Val Wing Leu Ser Gly Met 115 120 125 Asn Ser Tyr Lys Thr Leu Ser Thr Thr Wing Wing Wing Arg Asn Wing Wing 130 135 140 Leu Asn Val Val Val Lys Asn Leu Wing Asp Arg His Wing Gly Thr Gly 145 150 155 160 He Thr Val Asn Wing He Ser Pro Gly Phe Val Val Wing Glu Pro Asp 165 170 175 0 Wing Glu Val Asn Arg Wing Asn Gly Asp Thr Thr Trp Arg Arg Ser Arg 180 185 190 Arg Arg Ser Arg Phe Cys Cys Arg Arg Ala Pro His Gln Phe Leu Glu 195 200 205 Arg Leu Phe Arg Trp Asp He Arg Arg Arg Wing Being Ser Phe Leu Ser 210 215 220 Ser Arg Glu Leu Pro Lys Arg Lys His Pro Arg Val Arg Wing 225 230 235 < 210 > 93 < 211 > 329 < 212 > DNA 5 < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (306¡ 1 < 223 > RXA02133 < 400 > 93 gaa aac ccc tac att ggc gga gct gga tac aac gca gca aaa ttc ggt 48 Glu Asn Pro Tyr He Gly Gly Wing Gly Tyr Asn Wing Ala Lys Phe Gly 1 5 10 15 gta gca gca ttc aac cgt gtg ctt cgc ttg gaa acc fall cag cag acc 96 Val Ala Ala Phe Asn Arg Val Leu Arg Leu Glu Thr His Gln Gln Thr 20 25 30 ctt cgc gta tet gag ate gat cca ggt cga gtt gcc acg gaa gaa ttc 144 Leu Arg Val Ser Glu He Asp Pro Gly Arg Val Wing Thr Glu Glu Phe 35 40 45 tcc etc gtt cgt ttc ggc gga gat aaa gaa cgc gca gaa gca gtc tat 192 Be Leu Val Arg Phe Gly Gly Asp Lys Glu Arg Wing Glu Wing Val Tyr 50 55 60 gac gac gtc etc aac etc. acc gct gaa gac ate gca gag tet gtg cgt 240 Asp Asp Val Leu Asn Leu Thr Ala Glu Asp He Ala Glu Ser Val Arg 65 70 75 80 tgg gtc gcg age ctt cca aag falls atg aac att gac cgc atg cgt att 288 Trp Val Ala Ser Leu Pro Lys His Met Asn He Asp Arg Met Arg He 85 90 95 here ect cgc gat cag gtc taaaacccgc actcttttga aat 329 Thr Pro Arg Asp Gln Val 100 < 210 > 9 1 < 211 > 102 < 212 > PRT < 213 > Corynebact: er? Um glutamicum < 400 > 94 Glu Asn Pro Tyr He Gly Gly Wing Gly Tyr Asn Wing Ala Lys Phe Gly 1 5 10 15 Val Ala Ala Phe Asn Arg Val Leu Arg Leu Glu Thr His Gln Gln Thr 20 25 30 Leu Arg Val Ser Glu He Asp Pro Gly Arg Val Ala Thr Glu Glu Phe 35 40 45 Ser Leu Val Arg Phe Gly Gly Asp Lys Glu Arg Wing Glu Wing Val Tyr 50 55 60 Asp Asp Val Leu Asn Leu Thr Wing Glu Asp He Wing Glu Ser Val Arg 65 70 75 80 Trp Val Wing Ser Leu Pro Lys His Met Asn He Asp Arg Met Arg He 85 90 95 Thr Pro Arg Asp Gln Val 100 < 210 > 95 < 211 > 1347 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101). . (1324) < 223 > RXN01 H 4 < 400 > 95 ttcggtggaa, cat "tcegea a, gctggtgct gccgcagctt ttaigaaaicgg ictcaagcaat 60 ttcgacaigat ictctctgcac tctaa¡attaa ggatcaaaaa atg aac ect caa gat 115 Met Asn Pro Gln Asp 1 5 att gtc ate tgt tcc cca ttg cgc acc cca gtt ggt gct tac ggc gga 163Jp.

He Val He Cys Ser Pro Leu Arg Thr Pro Val Gly Wing Tyr Gly Gly 10 15 20 tcc ttc acc ggc gtc ect gtt gaa ttg gcc acc acc gtg ate aac 211 Be Phe Thr Gly Val Pro Val Glu Glu Leu Wing Thr Thr Val He Asn 25 30 gcg gtg ate gtt gag gca acc ggc ate acc ggc gac gat gtg gac gat ctg 259 Wing Hem Glu Wing Thr Gly He Thr Gly Asp Asp Val Asp Asp Leu 40 45 50 ate etc ggc cag gca tcc ccc aac ggt gcg gct cca gca ctg ggc cgt 307 He Leu Gly Gln Wing Pro Pro Asn Gly Ala Wing Pro Wing Leu Gly Arg 55 60 65 gtt gtt gct cta gat tcc aag ctt ggc caa aac gtt cca ggc atg cag 355 Val Val Ala Leu Asp Ser Lys Leu Gly Gln Asn Val Pro Gly Met Gln 70 75 80 85 ctt gat cgc cgc tgt ggt tcc ggc ctg cag gca ate gtc acc gct gct 403 Leu Asp Arg Arg Cys Gly Ser Gly Leu Gln Wing Hew Val Thr Wing Wing 90 95 100 gca fall gtt gca tcc ggc gct gct gat ctg ate ate gca ggt ggc gca 451 Ala His Val Ala Ser Gly Ala Ala Asp Leu He He Ala Ala Gly Ala 105 110 115 gaa tcc atg age cgc gtt gag tac acc gtg tcc ggc gat ate cgt tgg 499 Glu Ser Met Ser Arg Val Glu Tyr Thr Val Ser Gly Asp He Arg Trp 120 125 130 ggt gtc aag ggc ggc gac atg cag ctt cgt gac cgc ctt gca gaa gca 547 Gly Val Lys Gly Gly Asp Met Gln Leu Arg Asp Arg Leu Wing Glu Wing 135 140 145 cgc gaa acc gct ggc gga cgc aac falls ccg ate ect ggt ggc atg ate 595 Arg Glu Thr Wing Gly Gly Arg Asn His Pro He Pro Gly Gly Met He 150 155 160 165 gag acc gct gag aac ctg cgt cgc gaa tac ggc ate tcc cgc gag gag 643 Glu Thr Ala Glu Asn Leu Arg Arg Glu Tyr Gly He Ser Arg Glu Glu 170 175 180 cag gac aag ate tcc gca gcg tcc cag cag cgt tgg ggc aag gct gct 691 Gln Asp Lys He Ser Wing Wing Gln Gln Arg Trp Gly Lys Wing Wing 185 190 195 gat gcg ggg ctt ttc gac gac gac ate gtg cca gtc acc gtc ect gcc 739 Asp Wing Gly Leu Phe Asp Asp Glu He Val Pro Pro Val Thr Val Pro Wing 200 205 210 aag aag cgc ggc cag gag cca acc ate gtt tet cga gac gag cat ggt 787 Lys Lys Arg Gly Gln Glu Pro Thr He Val Ser Arg Asp Glu His Gly 215 220 225 cga cca gga here acc gtc gaa aag ctt gct gct ttg cgc ccc ate atg 835 Arg Pro Gly Thr Thr Val Glu Lys Leu Ala Wing Leu Arg Pro He Met 230 235 240 245 ggc cgc cag gat gcg gaa gca acc gtc acc gct ggc aac gcg ccc ggc 883 Gly Arg Gln Asp Wing Glu Wing Thr Val Thr Wing Gly Asn Wing Ser Gly 250 255 260 caat aat gat ggc gct gct gcc gtc ate gtg acc act cgc gcc aag gcc 931 iftá ^ j ^^ j ^^ íjá ^ fe ^ Gln Asn Asp Gly Ala Ala Ala Val He Val Thr Thr Arg Ala Lys Ala 265 270 275 gag gag aag ggc ctg cgc cca gtc atg cgt ttg gct ggc tgg tet gtg 979 Glu Glu Lys Gly Leu Arg Pro Val Met Arg Leu Wing Gly Trp Ser Val 280 285 290 gct gct gcc ccc gag acc atg ggt att gga ect gtt ect gcc acc 1027 Wing Wing Val Pro Pro Glu Thr Met Gly He Gly Pro Val Pro Wing Thr 295 300 305 aag aag gtc ctg gat cgt ttg ggc ctt acc ctg gag gac ate ggc gcg 1075 Lys Lys Val Leu Asp Arg Leu Gly Leu Thr Leu Glu Asp He Gly Ala 310 315 320 325 ate gaa etc aac gaa gct ttc gca gct cag gca ctg tet gtg ctg aag 1123 He Glu Leu Asn Glu Wing Phe Wing Wing Gln Wing Leu Ser Val Leu Lys 330 335 340 gaa tgg aac att tet tgg gaa gat gag cgc gtc aac cca ctg ggt tcc 1171 Glu Trp Asn He Ser Trp Glu Asp Glu Arg Val Asn Pro Leu Gly Ser 345 350 355 ggt att tcc atg gga falls cca gtc ggt gcc ggt acc ggt cgc atg gca 1219 Gly He Ser Met Gly His Pro Val Gly Ala Thr Gly Ala Arg Met Wing 360 365 370 gta acc ttg gct falls cgc atg cag cgt gaa aac act cag tac gga ctg 1267 Val Thr Leu Ala His Arg Met Gln Arg Glu Asn Thr Gln Tyr Gly Leu 375 380 385 gcc acc atg tgc ate ggt ggc ggc cag ggt ctt gca gct gtc ttt gaa 1315 Wing Thr Met Cys He Gly Gly Gly Gln Gly Leu Wing Wing Val Phe Glu 390 395 400 405 aag gag aac taaaaatggc t: attttgcac age 1347 Lys Glu Asn < 210 > 96 < 211 > 408 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 96 Met Asn Pro Gln Asp He Val He Cys Ser Pro Leu Arg Thr Pro Val 1 5 10 15 Gly Wing Tyr Gly Gly Ser Phe Thr Gly Val Pro Val Glu Glu Leu Wing 20 25 30 Thr Thr Val He Asn Wing He Val Glu Wing Thr Gly He Thr Gly Asp 35 40 45 Asp Val Asp Asp Leu He Leu Gly Gln Wing Pro Pro Asn Gly Wing Wing 50 55 60 Pro Wing Leu Gly Arg Val Val Wing Leu Asp Being Lys Leu Gly Gln Asn 65 70 75 80 Val Pro Gly Met Gln Leu Asp Arg Arg Cys Gly Ser Gly Leu Gln Wing 85 90 95 He Val Thr Ala Ala Ala His Val Ala Ser Gly Ala Ala Asp Leu He 100 105 110 He Ala Gly Gly Ala Glu Ser Met Ser Arg Val Glu Tyr Thr Val Ser 115 120 125 Gly Asp He Arg Trp Gly Val Lys Gly Gly Asp Met Gln Leu Arg Asp 130 135 140 Arg Leu Wing Glu Wing Arg Glu Thr Wing Gly Gly Arg Asn His Pro He 145 150 155 160 Pro Gly Gly Met He Glu Thr Wing Glu Asn Leu Arg Arg Glu Tyr Gly 165 170 175 He Be Arg Glu Glu Gln Asp Lys He Ser Wing Wing Gln Gln Arg 180 185 190 Trp Gly Lys Wing Wing Asp Wing Gly Leu Phe Asp Asp Glu He Val Pro 195 200 205 Val Thr Val Pro Wing Lys Lys Arg Gly Gln Glu Pro Thr He Val Ser 210 215 220 Arg Asp Glu His Gly Arg Pro Gly Thr Thr Val Glu Lys Leu Wing Ala • 225 230 235 240 Leu Arg Pro He Met Gly Arg Gln Asp Wing Glu Wing Thr Val Thr Ala 245 250 255 Gly Asn Wing Gly Gln Asn Asp Gly Wing Wing Wing Val Thr 260 265 270 Thr Arg Wing Lys Wing Glu Glu Lys Gly Leu Arg Pro Val Met Arg Leu 275 280 285 Wing Gly Trp Ser Val Wing Wing Val Pro Pro Glu Thr Met Gly He Gly 290 295 300 Pro Val Pro Wing Thr Lys Lys Val Leu Asp Arg Leu Gly Leu Thr Leu 305 310 315 320 Glu Asp He Gly Wing He Glu Leu Asn Glu Wing Phe Wing Wing Gln Wing 10 325 330 335 Leu Ser Val Leu Lys Glu Trp Asn He Ser Trp Glu Asp Glu Arg Val 340 345 350 • Asn Pro Leu Gly Ser Gly He Ser Met Gly His Pro Val Gly Ala Thr 355 360 365 Gly Ala Arg Met Ala Val Thr Leu Ala His Arg Met Gln Arg Glu Asn 370 375 380 Thr Gln Tyr Gly Leu Wing Thr Met Cys He Gly Gly Gly Gln Gly Leu 385 390 395 400 Wing Wing Val Phe Glu Lys Glu Asn 405 15 <; 210 > 97 < 211 > 815 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 400 > 97 cgc ctt gca gaa gca cgc gaa acc gct ggc gga cgc aac falls ccg ate 48 20 Arg Leu Wing Glu Wing Arg Glu Thr Wing Gly Gly Arg Asn His Pro He 1 5 10 15 ect ggt ggc atg ate gag acc gct gag aac ctg cgc cgc gaa tac ggc 96 Pro Gly Gly Met He Glu Thr Wing Glu Asn Leu Arg Arg Glu Tyr Gly 20 25 30 ate tcc cgc gag gag cag gac aag ate tcc gca gcg tcc cag cag cgt 144 He Ser Arg Glu Glu Gln Asp Lys He Ser Wing Wing Gln Gln Arg 35 40 45 tgg ggc aag gct gct gat gcg ggg ctt ttc gac gac gac ate gtg cca 192 Trp Gly Lys Ala Ala Asp Ala Gly Leu Phe Asp Asp Glu He Val Pro 50 55 60 gtc acc gtc ect gcc aag aag cgc ggc cag gag cca acc ate gtt tet 240 25 Val Thr Val Pro Wing Lys Lys Arg Gly Gln Glu Pro Thr He Val Ser 65 70 75 80 cga gac gag cat ggt cga cca gga here acc gtc gaa aag ctt gct gct Arg Asp Glu His Gly Arg Pro Gly Thr Thr Val Glu Lys Leu Ala Wing 85 90 95 ttg cgc ccc ate atg ggc cgc cag gat gcg gaa gca acc gtc acc gct 336 Leu Arg Pro He Met Gly Arg Gln Asp Wing Glu Wing Thr Val Thr Wing 100 105 110 ggc aac gcg tcc ggc ca gt ggc cat ggc gct gct gcc gtc ate gtg acc 384 Gly Asn Ala Ser Gly Gln Asn Asp Gly Ala Ala Ala Val He Val Thr • 115 120 125 act cgc gcc aag gcc gag gag aag ggc ctg cgc cca gtc atg cgt ttg 432 Thr Arg Ala Lys Ala Glu Glu Lys Gly Leu Arg Pro Val Met Arg Leu 130 135 140 gct ggc tgg tet gtg gct gct gtt ccc cca gag acc atg ggt att gga 480 Wing Gly Trp Ser Val Wing Wing Val Pro Pro Glu Thr Met Gly He Gly 145 150 155 160 ect gtt ect gcc acc eag aag gtc ctg gat cgt ttg ggc ctt acc ctg 528 Pro Val Pro Wing Thr Lys Lys Val Leu Asp Arg Leu Gly Leu Thr Leu 165 170 175 gag gac ate ggc gcg ate gaa etc aac gaa gct ttc gca gct cag gca 576 Glu Asp He Gly Ala He Glu Leu Asn G lu Ala Phe Ala Ala Gln Ala 10 180 185 190 ctg tet gtg ctg aag gaa tgg aac att tet tgg gaa gat gag cgc gtc 624 Leu Ser Val Leu Lys Glu Trp Asn He Ser Trp Glu Asp Glu Arg Val 195 200 205 aac cca ctg ggt tcc ggt att tcc atg gga drops cca gtc ggt gcc acc 672 Asn Pro Leu Gly Ser Gly He is Met Gly His Pro Val Gly Wing Thr 210 215 220 ggt gct cgc atg gca gta acc ttg gct drops cgc atg cag cgt gaa aac 720 Gly Ala Arg Met Ala Val Thr Leu Ala His Arg Met Gln Arg Glu Asn 225 230 235 240 act cag tac gga ctg gcc acc atg tgc ate ggt ggc ggc cag ggt ctt 15 Thr Gln Tyr Gly Leu Ala Thr Met Cys He Gly Gly Gly Gln Gly Leu 245 250 255 gca gct gtc ttt gaa aag gag aac taaaaatggc tattttgcac age 815 Ala Ala Val Phe Glu Lys Glu Asn 260 < 210 > 9 £ 1 < 211 > 264 • < 212 > PRT < 213 > Ccirynebact: erium glutamicum < 400 > 98 Arg Leu Wing Glu Wing Arg Glu Thr Wing Gly Gly Arg Asn His Pro He 20 1 5 10 15 Pro Gly Gly Met He Glu Thr Wing Glu Asn Leu Arg Arg Glu Tyr Gly 20 25 30 He Ser Arg Glu Glu Gln Asp Lys He Be Ala Ala Be Gln Gln Arg 35 40 45 Trp Gly Lys Ala Ala Asp Ala Gly Leu Phe Asp Asp Glu He Val Pro 50 55 60 Val Thr Val Pro Ala Lys Lys Arg Gly Gln Glu Pro Thr He Val Ser 65 70 75 80 Arg Asp Glu His Gly Arg Pro Gly Thr Thr Val Glu Lys Leu Ala Wing 85 90 95 25 Leu Arg Pro He Met Gly Arg Gln Asp Wing Glu Wing Thr Val Thr Wing ltá-LJ ».¿.?. *.? iá .. 100 105 110 Gly Asn Wing Ser Gly Gln Asn Asp Gly Wing Wing Wing Val Thr 115 120 125 Thr Arg Wing Lys Wing Glu Glu Lys Gly Leu Arg Pro Val Met Arg Leu 130 135 140 Wing Gly Trp Ser Val Wing Wing Val Pro Pro Glu Thr Met Gly He Gly 145 150 155 160 Pro Val Pro Wing Thr Lys Lys Val Leu Asp Arg Leu Gly Leu Thr Leu • 165 170 175 Glu Asp He Gly Wing He Glu Leu Asn Glu Wing Phe Wing Wing Gln Wing 180 185 190 Leu Ser Val Leu Lys Glu Trp Asn He Ser Trp Glu Asp Glu Arg Val 195 200 205 Asn Pro Leu Gly Ser Gly He Ser Met Gly His Pro Val Gly Ala Thr 210 215 220 Gly Wing Arg Met Wing Val Thr Leu Wing His Arg Met Gln Arg Glu Asn 225 230 235 240 Thr Gln Tyr Gly Leu Wing Thr Met Cys He Gly Gly Gly Gln Gly Leu 245 250 255 Wing Wing Val Phe Glu Lys Glu Asn 10 260 < 210 > 99 • < 211 > 978 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (955) < 223 > RXA01894 15 < 400 > 99 agaatttttt < egaaaatgct ggcaccatca acagtgacat tgttagaaac ttcaaggaga 60 acccatgaat 115 1 5 aat aat gcg ggt cga gat etc aaa gct gcc att gct gtg ggg ate gga 163 Asn Asn Wing Gly Arg Asp Leu Lys Wing Wing He Wing Val Gly He Gly 10 15 20 • ctg ggg gtc ctg gtt ctt ttg ggg att gtc cta age cca tgg ggt tgg 211 Leu Gly Val Leu Val Leu Leu Gly He Val Leu Ser Pro Trp Gly Trp 25 30 35 tac ate etc gtt gca ggt ttt atg gct gca gca here tgg gaa gtt ggt 259 20 Tyr He Leu Val Wing Gly Phe Met Wing Wing Wing Thr Trp Glu Val Gly 40 45 50 age aga ctt aaa gaa ggc ggc tat cat ttg cca ctg att atg ate 307 Ser Arg Leu Lys Glu Gly Gly Tyr His Leu Pro Leu Pro He Met He 55 60 65 ate ggc ggt cag gca ate ate tgg ctg tea tgg cca ttt ggc acg atg 355 He Gly Gly Gln Ala He He Trp Leu Ser Trp Pro Phe Gly Thr Met 70 75 80 85 ggc att ttg gcg tet ttt gtg gcc act gtg ttg gtg ctg atg tat ttc 403 Gly He Leu Wing Being Phe Val Wing Thr Val Leu Val Leu Met Tyr Phe 90 95 100 cga att ttc tac aat ggc acg gaa aaa gaa gcc cgc aac tat ttg agg 451 25 Arg He Phe Tyr Asn Gly Thr Glu Lys Glu Wing Arg Asn Tyr Leu Arg ¡M i A, '^ S ^ J ^^^ - *** »» 105 110 115 gac acc tet gtg ggc ate ttc gtg etc acc tgg att cca ttg ttc gga 499 Asp Thr Ser Val Gly He Phe Val Leu Thr Trp He Pro Leu Phe Gly 120 125 130 age ttc gct gcg atg ctg tcg ctg atg cag aac aat ccg ggt 547 Be Phe Ala Ala Met Leu Ser Leu Met Gln Asn Asn Ser He Pro Gly 135 140 145 here tat ttc att ttg acg ttc atg ctg tgt gtg ate gca tcg gat gtg 595 Thr Tyr Phe He Leu Thr Phe Met Leu Cys Val He Wing Being Asp Val • 150 155 160 165 ggc ggg tat gcg ggt gtg gtg ttc ttt gga tcg cca cg atg gcg ccg 643 Gly Gly Tyr He Wing Gly Val Phe Phe Gly Ser His Pro Met Wing Pro 170 175 180 ttg gtg agt ccg aag aag tet tgg gaa ggc ttt gcc ggc tcc att gtc 691 Leu Val Ser Pro Lys Lys Ser Trp Glu Gly Phe Wing Gly Ser He Val 185 190 195 tta gga tcg gtc act ggt gca etc agt gtt drops ttc ctg etc gat drops 739 Leu Gly Ser Val Thr Gly Ala Leu Ser Val His Phe Leu Leu Asp His 200 205 210 falls tgg tgg atg ggt gtg ate ttg ggt tgt gcc cta gtt gtg tgc gcc 787 10 His Trp Trp Met Gly Val He Leu Gly Cys Wing Leu Val Val Cys Wing 215 220 225 acg ttg ggt gac ttg gtt gag tcg cag ttc aaa cgc gat ttg ggc ate 835 Thr Leu Gly Asp Leu Val Glu Ser Gln Phe Lys Arg Asp Leu Gly He • 230 235 240 245 aag gat atg tcg aac ctt ctt cca cca ggc cae ggc gga ttg atg gac cgt 883 Lys Asp Met Ser Asn Leu Pro Gly His Gly Gly Leu Met Asp Arg 250 255 260 ttg gat ggc atg etc ccg gcc gcg atg gtg acg tgg ttg ate ctg agt 931 Leu Asp Gly Met Leu Pro Wing Ala Met Val Thr Trp Leu He Leu Ser 265 270 275 gtg ate age age tcg tat ccg tcg taaagctt: gg gccagcttta agt 978 15 Val I Ser Ser Ser Ser Tyr Pro Ser 280 285 < 210 > 100 < 211 > 285 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 100 Met Pro Lys Pro Lys Asn Asn Wing Gly Arg Asp Leu Lys Ala Wing He 1 5 10 15 Wing Val Gly He Gly Leu Gly Val Leu Val Leu Leu Gly He Val Leu 20 20 25 30 Ser Pro Trp Gly Trp Tyr He Leu Val Ala Gly Phe Met Ala Ala Ala 35 40 45 Thr Trp Glu Val Gly Ser Arg Leu Lys Glu Gly Gly Tyr His Leu Pro 50 55 60 Leu Pro He Met He He Gly Glly Gln Ala He He Trp Leu Ser Trp 65 70 75 80 Pro Phe Gly Thr Met Gly He Leu Wing Being Phe Val Wing Thr Val Leu 85 90 95 Val Leu Met Tyr Phe Arg He Phe Tyr Asn Gly Thr Glu Lys Glu Wing 100 105 110 Arg Asn Tyr Leu Arg Asp Thr Ser Val Gly He Phe Val Leu Thr Trp 25 115 120 125 He Pro Leu Phe Gly Ser Phe Wing Wing Met Leu Ser Leu Met Gln Asn 130 135 140 Asn Ser He Pro Gly Thr Tyr Phe He Leu Thr Phe Met Leu Cys Val 145 150 155 160 He Wing Being Asp Val Gly Gly Tyr He Wing Gly Val Phe Phe Gly Ser 165 170 175 His Pro Met Ala Pro Leu Val Ser Pro Lys Lys Ser Trp Glu Gly Phe 180 185 190 • Wing Gly Ser He Val Leu Gly Ser Val Thr Gly Wing Leu Ser Val His 195 200 205 Phe Leu Leu Asp His His Trp Trp Met Gly Val He Leu Gly Cys Wing 210 215 220 Leu Val Val Cys Wing Thr Leu Gly Asp Leu Val Glu Ser Gln Phe Lys 225 230 235 240 Arg Asp Leu Gly He Lys Asp Met Ser Asn Leu Leu Pro Gly His Gly 245 250 255 Gly Leu Met Asp Arg Leu Asp Gly Met Leu Pro Ala Wing Met Val Thr 260 265 270 Trp Leu He Leu Ser Val He Ser Ser Ser Tyr Pro Ser 275 280 285 10 <; 210 > 101 < 211 > 600 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (577) < 223 > RXA02599 < 400 > 101 15 gattcaageat < cataegatgt cggagattgt ggc: gtt gttacaggag c ^ agttgcaac 60 cgggatttgt 1atgcraetc zc tacttgcgta aaggagaatt atg gat cag cta ate 115 Met Asp Gln Leu He 1 5 etc gac gca ttt ate ggc ttg aga gtg act tgg ctg agt ccg gtg att 163 Leu Asp Ala Phe He Gly Leu Arg Val Thr Trp Leu Ser Pro Val He 10 15 20 att ttg ttc acc cag etc acc ggg cca here ctg atg ttt gtg tat gcg 211 • He Leu Phe Thr Gln Leu Thr Gly Pro Thr Leu Met Phe Val Tyr Wing 25 30 35 ctt gtg tgg ggc ttg ttg cgc aag age gcc act gcc ccg ate gcg gtg 259 Leu Val Trp Gly Leu Leu Arg Lys Ser Ala Thr Ala Pro He Wing Val 20 40 45 50 ggg ctg gct aat ctg ate agt cat ttt etc aag agg gcg ttt gaa cgg 307 Gly Leu Wing Asn Leu He Ser His Phe Leu Lys Arg Wing Phe Glu Arg 55 60 65 ect cga cca aat here gca gag falls ttg gtt gta gta gaa act aac ttt tea 355 Pro Arg Pro Asn Thr Wing Glu His Leu Val Val Glu Thr Asn Phe Ser 70 75 80 85 ttc ect tet ggt cat gct gtg ggc gct gca gca tgt gcc gtg gca gtg 403 Phe Pro Ser Gly His Wing Val Gly Wing Wing Wing Cys Wing Val Wing Val 90 95 100 ggg tac tcc gtg aac cgg tgg tgg tgg aaa etc acg ctg tgg gta ate gcg 451 Gly Tyr Ser Val Asn Arg Trp Trp Lys Leu Thr Leu Trp Val He Wing 25 105 110 115 ctg ctt gtg ggg ctg tet cgg ttg tat gtc ggt gtg cat tgg ccc age 499 Leu Leu Val Gly Leu Ser Arg Leu Tyr Val Gly Val His Trp Pro Ser 120 125 130 gat gtg ctt gcc ggc tgg gcc ate ggt gcg ttg act tea gtg gtg gtg 547 Asp Val Leu Wing Gly Trp Wing He Gly Wing Leu Thr Ser Val Val Val 135 140 145 ttt acc tgg aac etc etc cag cgc cgc tgaaaccact gctgaaagtg 597 Phe Thr Ser Trp Asn Leu Leu Gln Arg Arg 150 155 • gta 600 < 210 > 102 < 211 > 159 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 102 Met Asp Gln Leu He Leu Asp Wing Phe He Gly Leu Arg Val Thr Trp 1 5 10 15 Leu Ser Pro Val He He Leu Phe Thr Gln Leu Thr Gly Pro Thr Leu 10 20 25 30 Met Phe Val Tyr Ala Leu Val Trp Gly Leu Leu Arg Lys Ser Wing Thr 35 40 45 Wing Pro Wing Val Gly Leu Wing Asn Leu He Ser His Phe Leu Lys 50 55 60 Arg Wing Phe Glu Arg Pro Arg Pro Asn Thr Wing Glu His Leu Val Val 65 70 75 80 Glu Thr Asn Phe Ser Phe Pro Ser Gly His Wing Val Gly Wing Wing Wing 85 90 95 Cys Wing Wing Val Gly Tyr Ser Val Asn Arg Trp Trp Lys Leu Thr 100 105 110 Leu Trp Val He Wing Leu Leu Val Gly Leu Ser Arg Leu Tyr Val Gly 15 115 120 125 Val His Trp Pro Ser Asp Val Leu Wing Gly Trp Wing He Gly Wing Leu 130 135 140 Thr Ser Val Val Val Phe Thr Ser Trp Asn Leu Leu Gln Arg Arg 145 150 155 < 210 > 103 < 211 > 999 < 212 > DNA • < 213 > Corynebacterium glutamicum < 220 > 20 < 221 > CDS < 222 > (101) .. (976) < 223 > RXN02638 < 400 > 103 ctctgttgtt gttcctgagg cgcttcgtcc attegtgggc aaagacgtgc tcaagccagt 60 tcgcgtgc ggttaattaa ggttaattaa gcggaaagct cgtggtcgac atg gtc aaa agg ttt 115 Met Val Lys Arg Phe 1 5 ggc ttt ttc gta gag gat tcc ctg ect aag gtt ccg ctg cat ccc gaa 163 Gly Phe Phe Val Glu Asp Ser Leu Pro Lys Val Pro Leu H s Pro Glu 10 15 20 25 gag tea cgg gag acg ttt tat ggg cgc ate ate att agt gct ggg cgg 211 Glu Be Arg Glu Thr Phe Tyr Gly Arg He He Be Ser Wing Val Arg 25 30 35 acg gtg atg aaa gcc cag gat gtg cag att tcc ate ttc ggt gcg gag 259 Thr Val Met Lys Wing Gln Asp Val Gln He Ser He Phe Gly Wing Glu 40 45 50 aac att ccg acc acc ggc ggc gca ctt ttc gca tea acc acta ctg gtt 307 Asn He Pro Thr Thr Gly Gly Ala Leu Phe Wing Thr Thr Leu Val 55 60 65 att atg act tea ttc tgg gtg gta tcc ccc gca ttc ggg cgg ggt aag 355 He Met Thr Ser Phe Trp Val Val Ser Pro Ala Phe Val Arg Gly Lys 70 75 80 85 cgc ctg gtt cga ttc atg gcg aag aag gaa att tcc gac acc cca gtt 403 Arg Leu Val Arg Phe Met Ala Lys Lys Glu He Phe Asp Thr Pro Val 90 95 100 gtc ggc acc etc atg cgc tgg atg aag drops gtc tet gtg gac cgc tcc 451 Val Gly Thr Leu Met Arg Trp Met Lys His Val Ser Val Asp Arg Ser 105 110 115 gca ggt gcc ggt tcc atg gaa gat gcg cgg aag cgt etc gac gcc ggc 499 Wing Gly Wing Gly Being Met Glu Asp Wing Arg Lys Arg Leu Asp Wing Gly 120 125 130 10 age etc gtc ggt ate ttc ect gag gcg acg gtg tea cgg tcc ttt gaa 547 Ser Leu Val Gly He Phe Pro Glu Wing Thr Val Ser Arg Ser Phe Glu 135 140 145 • ate aag gaa cta aaa act ggc gcc gtc cgc ate gcc gac age gct aac 595 He Lys Glu Leu Lys Thr Gly Wing Val Arg He Wing Asp Ser Wing Asn 150 155 160 165 gtt ccg ctg ctg cca ctt att att tgg ggc ggc cag cgc ate ate acc 643 Val Pro Leu Leu Pro Leu He He Trp Gly Gly Gln Arg He He Thr 170 175 180 aaa gac ate gag cgc gac tcc ggc cgc tcc falls ate ccc gta ttc ate 691 Lys Asp He Glu Arg Asp Phe Gly Arg Ser His He Pro Val Phe He 185 190 195 15 age gtg ggt gaa ccc gtc gac gcc age gcc gat ccc gac gaa gca acg 739 Ser Val Gly Glu Pro Val Asp Wing Ser Gly Asp Pro Asp Glu Wing Thr 200 205 210 gaa cgc etc tac gag gct atg aaa aag ctt etc gac gaa acc cgc acc 787 Glu Arg Leu Tyr Glu Wing Met Lys Lys Leu Leu Asp Glu Thr Arg Thr 215 220 225 gcc tac gaa caa aag tat ggc cca ttc gaa ggt gga gaa ttg tgg cgc 835 Wing Tyr Glu Gln Lys Tyr Gly Pro Phe Glu Gly Gly Glu Glu Leu Trp Arg • 230 235 240 245 ccg aaa tcc ggc ggc cg gcc cg acg tgc gag cag gcg aaa atg 883 Pro Lys Ser Leu Gly Gly Gly Wing Pro Thr Leu Glu Gln Wing Ala Met 250 255 260 20 ttg gaa ate gcc gaa cgg gag cgt cga caga gca aaa cgc gcg gca aag 931 Leu Glu He Wing Glu Arg Glu Arg Arg Gln Wing Lys Arg Wing Wing Lys 265 270 275 gtc gcc aag aaa cgc acc acc ttt ata agg aaa ate ttt aaa aaa 976 Val Ala Lys Lys Arg Thr Thr Phe He Arg Lys He Phe Lys Lys 280 285 290 tgattgcact gggttcagcg ccc 999 <; 210 > 104 < 211 > 292 < 212 > PRT < 213 > Corynebacterium glutamicum 25 < 400 > 104 Met Val Lys Arg Phe Gly Phe Phe Val Glu Asp Ser Leu Pro Lys Val 1 5 10 15 Pro Leu His Pro Glu Glu Ser Arg Glu Thr Phe Tyr Gly Arg He He 20 25 30 He Ser Wing Val Arg Thr Val Met Lys Wing Gln Asp Val Gln Be Ser 35 40 45 He Phe Gly Wing Glu Asn He Pro Thr Thr Gly Gly Wing Leu Phe Wing 50 55 60 Thr Being Thr Leu Val He Met Thr Being Phe Trp Val Val Ser Pro Wing 65 70 75 80 Phe Val Arg Gly Lys Arg Leu Val Arg Phe Met Ala Lys Lys Glu He 85 90 95 Phe Asp Thr Pro Val Val Gly Thr Leu Met Arg Trp Met Lys His Val 100 105 110 Ser Val Asp Arg Ser Ala Gly Ala Gly Ser Met Glu Asp Ala Arg Lys 115 120 125 Arg Leu Asp Wing Gly Ser Leu Val Gly He Phe Pro Glu Wing Thr Val 130 135 140 Ser Arg Ser Phe Glu He Lys Glu Leu Lys Thr Gly Wing Val Arg He 10 145 150 155 160 Wing Asp Ser Wing Asn Val Pro Leu Leu Pro Leu He He Trp Gly G y 165 170 175 • Gln Arg He He Thr Lys Asp He Glu Arg Asp Phe Gly Arg Ser His 180 185 190 He Pro Val Phe He Ser Val Gly Glu Pro Val Asp Ala Ser Gly Asp 195 200 205 Pr or Asp Glu Wing Thr Glu Arg Leu Tyr Glu Wing Met Lys Lys Leu Leu 210 215 220 Asp Glu Thr Arg Thr Wing Tyr Glu Gln Lys Tyr Gly Pro Phe Glu Gly 225 230 235 240 Gly Glu Leu Trp Arg Pro Lys Ser Leu Gly Gly Gly Ala Pro Thr Leu 15 245 250 255 Glu Gln Ala Lys Met Leu Glu He Wing Glu Arg Glu Arg Arg Gln Wing 260 265 270 Lys Arg Ala Wing Lys Val Wing Lys Lys Arg Thr Thr Phe He Arg Lys 275 280 285 He Phe Lys Lys 290 • < 210 > 105 < 211 > 534 < 212 > DNA < 213 > Corynebacterium glutamicum 20 < 220 > < 221 > CDS < 222 > (8) .. (511) < 223 > FRXA02638 < 400 > 105 atgaaga atg gcg cgg aag cgt ctt aac gcc ggc age etc gtc ggt ate 49 Met Ala Arg Lys Arg Leu Asn Ala Gly Ser Leu Val Gly He 10 ttc ect gag gcg acg gtg tea cgg tcc ttt gaa ate aag gaa cta aaa 97 Phe Pro Glu Ala Thr Val Ser Arg Ser Phe Glu He Lys Glu Leu Lys 25 15 20 25 30 act ggc gcc gtc cgc ate gcc gac age gct aac gtt ccg ctg ctg cca 145 Thr Gly Ala Val Arg He Ala Asp Ser Ala Asn Val Pro Leu Leu Pro 35 40 45 ctt att att tgg ggc ggc cag cgc ate ate acc aaa gac ate gag cgc 193 Leu He He Trp Gly Gly Gln Arg He He Thr Lys Asp He Glu Arg 50 55 60 gac ttc ggc cgc tcc falls ate ccc gta ttc ate age gtg ggt gaa ccc 241 Asp Phe Gly Arg Ser His He Pro Val Phe He Ser Val Gly Glu Pro 65 70 75 • gtc gac gcc age gcc gat ccc gac gaa gca acg gaa cgc etc tac gag 289 Val Asp Wing Ser Gly Asp Pro Asp Glu Wing Thr Glu Arg Leu Tyr Glu 80 85 90 gct atg aaa aag ctt etc gac gaa acc cgc acc gcc tac gaa caa aag 337 Wing Met Lys Lys Leu Leu Asp Glu Thr Arg Thr Wing Tyr Glu Gln Lys 95 100 105 110 tat ggc cca ttc gaa ggt gga gaa ttg tgg cgc ccg aaa tcc etc ggc 385 Tyr Gly Pro Phe Glu Gly Gly Glu Leu Trp Arg Pro Lys Ser Leu Gly 115 120 125 ggc ggc gcc cca acg ttg gag cag gcg aaa atg ttg gaa ate gcc gaa 433 Gly Gly Ala Pro Thr Leu Glu Gln Ala Lys Met Leu Glu He Ala Gl u 10 130 135 140 cgg gaa cgt cga caca gca aaa cgc gcg gca aag gtc gcc aag aaa cgc 481 Arg Glu Arg Arg Gln Ala Lys Arg Ala Ala Lys Val Ala Lys Lys Arg 145 150 155 # acc acc ttt ata agg aaa ate ttt aaa aaa tgattgcact gggttcagcg 531 Thr Thr Phe He Arg Lys He Phe Lys Lys 160 165 ccc 534 < 210 > 106 < 211 > 168 < 212 > PRT 15 < 213 > Corynebacterium glutamicum < 400 > 106 Met Wing Arg Lys Arg Leu Asn Wing Gly Ser Leu Val Gly He Phe Pro 1 5 10 15 Glu Wing Thr Val Ser Arg Ser Phe Glu He Lys Glu Leu Lys Thr Gly 20 25 30 Wing Val Arg He Wing Asp Ser Wing Asn Val Pro Leu Leu Pro Leu He 35 40 45 • He Trp Gly Gly Gln Arg He He Thr Lys Asp He Glu Arg Asp Phe 50 55 60 Gly Arg Ser His He Pro Val Phe He Ser Val Gly Glu Pro Val Asp 20 65 70 75 80 Wing Ser Gly Asp Pro Asp Glu Wing Thr Glu Arg Leu Tyr Glu Wing Met 85 90 95 Lys Lys Leu Leu Asp Glu Thr Arg Thr Wing Tyr Glu Gln Lys Tyr Gly 100 105 110 Pro Phe Glu Gly Gly Glu Leu Trp Arg Pro Lys Ser Leu Gly Gly Gly 115 120 125 Ala Pro Thr Leu Glu Gln Ala Lys Met Leu Glu He Ala Glu Arg Glu 130 135 140 Arg Arg Gln Ala Lys Arg Ala Ala Lys Val Ala Lys Lys Arg Thr Thr 145 150 155 160 Phe He Arg Lys He Phe Lys Lys 25 165 l. ? ? ? ^? .O.ái? L.tr < 210 > 107 < 211 > 637 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (637) < 223 > RXA00856 < 400 > 107 gttttta < gga, atag¡agtggg ctcaaigcttt gtgacaagtt ttttggagaa; atcaittacta 60 gtcgtagtct "tcaatttggg tgcaggtagg gtggaacacc gtg agt gat gta tea 115 Val Ser Asp Val Ser 1 5 gca ggc gta aat ggc gca caca gat cca age aat caa gcg gtc aag ect 163 Wing Gly Val Asn Gly Wing Gln Asp Pro Being Asn Gln Wing Val Lys Pro 10 15 20 tcc aac tgg aac ctt ccg aac ttc ttg acc age ttg cgt ate att gtc 211 10 Ser Asn Trp Asn Leu Pro Asn Phe Leu Thr Ser Leu Arg He He Val 25 30 35 ate ect ttg ttt gcg tgg ctt acg ctt aaa ggt gag acg gaa aac aat 259 # He Pro Leu Phe Wing Trp Leu Thr Leu Lys Gly Glu Thr Glu Asn Asn 40 45 50 gct ttt gcc tgg tgg gcg ttg gtt gtt ttc att ttg etc atg ate acc 307 Wing Phe Wing Trp Trp Wing Leu Val Val Phe He Leu Leu Met He Thr 55 60 65 gac aag ctt gac ggc gat att gcg cga gca cgt ggc ctg gtc act gac 355 Asp Lys Leu Asp Gly Asp He Wing Arg Wing Arg Gly Leu Val Thr Asp 70 75 80 85 ttt ggc aag ate gcg gat ccg att gcc gat aag gcg ttg atg acc here 403 15 Phe Gly Lys He Wing Asp Pro He Wing Asp Lys Wing Leu Met Thr Thr 90 95 100 gca ttt gtc tgt ttc aac ate ate ggc att ttg ccc tgg tgg gtc act 451 Wing Phe Val Cys Phe Asn He He Gly He Leu Pro Trp Trp Val Thr 105 110 115 gcg ttg att gtg ctt cga gag ttc ggc att acc ate tgg cgt ttc ttc 499 Wing Leu He Val Leu Arg Glu Phe Gly He Thr He Trp Arg Phe Phe 120 125 130 • caá ctg cgc gct gga aat gtt gtg ect gca tea aag ggg ggc aag ctt 547 Gln Leu Arg Wing Gly Asn Val Val Pro Wing Ser Lys Gly Gly Lys Leu 135 140 145 aag act gct ctg cag act gtt gcc gtt gct ctg tat ctg tgc ect ttc 595 20 Lys Thr Wing Leu Gln Thr Val Wing Val Wing Leu Tyr Leu Cys Pro Phe 150 155 160 165 cca agt tgg atg gat att cca age cag ate gtc atg tat gca 637 Pro Ser Trp Met Asp He Pro Ser Gln He Val Met Tyr Ala 170 175 < 210 > 108 < 211 > 179 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 108 25 Val Ser Asp Val Ser Wing Gly Val Asn Gly Wing Gln Asp Pro Ser Asn t * »k J j. * 1 5 10 15 Gln Ala Val Lys Pro Ser Asn Trp Asn Leu Pro Asn Phe Leu Thr Ser 20 25 30 Leu Arg He He Val He Pro Leu Phe Wing Trp Leu Thr Leu Lys Gly 35 40 45 Glu Thr Glu Asn Asn Wing Phe Wing Trp Trp Wing Leu Val Val Phe He 50 55 60 Leu Leu Met He Thr Asp Lys Leu Asp Gly Asp He Wing Arg Wing Arg 65 70 75 80 Gly Leu Val Thr Asp Phe Gly Lys He Wing Asp Pro He Wing Asp Lys 85 90 95 Wing Leu Met Thr Thr Wing Phe Val Cys Phe Asn He He Gly He Leu 100 105 110 Pro Trp Trp Val Thr Wing Leu He Val Leu Arg Glu Phe Gly He Thr 115 120 125 He Trp Arg Phe Phe Gln Leu Arg Wing Gly Asn Val Val Pro Wing Ser 130 135 140 Lys Gly Gly Lys Leu Lys Thr Wing Leu Gln Thr Val Wing Val Wing Leu 145 150 155 160 Tyr Leu Cys Pro Phe Pro Ser Trp Met Asp He Pro Ser Gln He Val 10 165 170 175 Met Tyr Ala < 210 > 109 • < 211 > 780 < 212 > DNA < 213 > Corynebact, erium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (757) < 223 > RXA02511 15 ccatgctitgc < gcaaigcatgg ggcact: atttg attggggcacc aggcactgtc < gacccaacgc 60 tgacttcagc < gatcicgtacc gcagcaccg; a aggagcactg atg ctg gga ctt cat 115 Met Leu Gly Leu His 1 5 gga cgt aag ect gcg cag gtt att gtt gag ect gtt gcc aaa ttg atg 163 Gly Arg Lys Pro Wing Gln Val He Val Glu Pro Val Wing Lys Leu Met 10 15 20 • ate aag ttg aag gtg acg ect aat cag etc acc tta gtc age gct ggc 211 He Lys Leu Lys Val Thr Pro Asn Gln Leu Thr Leu Val Ser Wing Gly 25 30 35 20 etc acc gtt ggg gtg gct ttg ctg ctg att ect acg ggg cat ttg att 259 Leu Thr Val Gly Val Ala Leu Leu Leu He Pro Thr Gly His Leu He 40 45 50 tgg gcg gca gtt ttg acg ggc ctg ttt gcg gct ttc gac atg att gat 307 Trp Ala Ala Val Leu Thr Gly Leu Phe Wing Wing Phe Asp Met He Asp 55 60 65 ggc acg gtt gct cgc atg cag ggt ggt ggc acc aaa ttt ggt gcc acc 355 Gly Thr Val Wing Arg Met Gln Gly Gly Gly Thr Lys Phe Gly Wing Thr 70 75 80 85 ttg gat gcc acg tgt gac cgc ate act gat ggt gca cta ttt ggt gcg 403 Leu Asp Wing Thr Cys Asp Arg He Thr Asp Gly Ala Leu Phe Gly Wing 90 95 100 25 att acc tgg tgg ctg gtg tat tcc tac gat g ca cca cag gca ttg gtc 451 fc-aa A.

He Thr Trp Trp Leu Val Tyr Ser Tyr Asp Ala Pro Gln Ala Leu Val 105 110 115 gct gcc tcc ttg gtt tgt ttg gtt gcc tcc cag gtg ate tet tac gtg 499 Ala Ala Ser Leu Val Cys Leu Val Ala Ser Gln Val He Ser Tyr Val 120 125 130 aaa gcc agg gga gacc gcc tcc gga ttc acc atg gac ggt etc gtg 547 Lys Wing Arg Gly Glu Wing Being Gly Phe Thr Met Asp Gly Gly Leu Val 135 140 145 gaa cgc ect gag cgt ctg att gtc age ctt gtt ggt ttg ggg gt ctg acc 595 Glu Arg Pro Glu Arg Leu He Val Ser Leu Val Gly Leu Gly Leu Thr 150 155 160 165 gga atg gtt cca tat gcc ate gat gtg gca ctg tgg gcc ctt gca 643 Gly Met Gly Val Pro Tyr Ala He Asp Val Wing Leu Trp Wing Leu Wing 170 175 180 gct agt att tac act gtt gtg cag cgc ttg gtc atg gct gga aag 691 Wing Gly Ser He Tyr Thr Val Val Gln Arg Leu Val Met Wing Gly Lys 185 190 195 tcc cca ttg gct aag gaa ttt acc aag gca cca gca ggt gcg aag gca 739 Pro Pro Leu Ala Lys Glu Phe Thr Lys Ala Pro Ala Gly Ala Lys Ala 200 205 210 10 gat tac age aac acc aaa taaaaattag ccg agggagc ate 780 Asp Tyr Ser Asn Thr Lys 215 • < 210 > 110 < 211 > 219 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 110 Met Leu Gly Leu His Gly Arg Lys Pro Wing Gln Val He Val Glu Pro 1 5 10 15 15 Val Wing Lys Leu Met He Lys Leu Lys Val Thr Pro Asn Gln Leu Thr 20 25 30 Leu Val Ser Wing Gly Leu Thr Val Gly Val Ala Leu Leu Leu He Pro 35 40 45 Thr Gly His Leu He Trp Wing Wing Val Leu Thr Gly Leu Phe Wing Wing 50 55 60 Phe Asp Met He Asp Gly Thr Val Wing Arg Met Gln Gly Gly Gly Thr 65 70 75 80 • Lys Phe Gly Wing Thr Leu Asp Wing Thr Cys Asp Arg He Thr Asp Gly 85 90 95 Wing Leu Phe Gly Wing He Thr Trp Trp Leu Val Tyr Ser Tyr Asp Wing 100 105 110 20 Pro Gln Ala Leu Val Wing Wing Ser Leu Val Cys Leu Val Ala Ser Gln 115 120 125 Val He Ser Tyr Val Lys Ala Arg Gly Glu Wing Ser Gly Phe Thr Met 130 135 140 Asp Gly Gly Leu Val Glu Arg Pro Glu Arg Leu Val Val Le Le Val 145 150 155 160 Gly Leu Gly Leu Thr Gly Met Gly Val Pro Tyr Wing He Asp Val Wing 165 170 175 Leu Trp Wing Leu Wing Wing Gly Ser He Tyr Thr Val Val Gln Arg Leu 180 185 190 Val Met Wing Gly Lys Ser Pro Leu Wing Lys Glu Phe Thr Lys Wing Pro 195 2 00 205 25 Ala Gly Ala Lys Ala Asp Tyr Ser Asn Thr Lys t ^^ g ^ É 210 215 < 210 > 111 < 211 > 678 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > 5 < 221 > CDS < 222 > (101) .. (655) < 223 > RXN02836 < 400 > 111 ccatcactcg gcttcaccgt ctacggtgct gcccgcagga cagagcgccc ccaaaagctc 60 gcttcagacg ggatccaccc cctcgagatg gacgtcaccg atg ate ate gat gaa 115 Met Thr He Asp Glu 1 5 cgt cgc cag ttc gag gtc aat gta ttc gcg atg gcc etc acc 163 Gly Arg Arg Gln Phe Glu Val Asn Val Phe Gly Ala Met Ala Leu Thr 10 15 20 JQ cga etc gtc ctg ccc falls atg cag aaa caa aag tgg ggg acg ate gtg 211 Arg Leu Val Leu Pro His Met Gln Lys Gln Lys Trp Gly Thr He Val 25 30 35 aac ate here tcg atg ggg aag ate tac acg ect etc tgg 259 • Asn He Thr Ser Met Gly Gly Lys He Tyr Thr Pro Leu Gly Gly Trp 40 45 50 tat falls acc aag tc gcc etc gag gcc etc tcg gac gcc etc cgc 307 Tyr His Gly Thr Lys Phe Ala Leu Glu Ala Leu Ser Asp Ala Leu Arg 55 60 65 ctg gag gtc gcc cca tcc gcc ate gac gtt gtt gtc ate gaa ccg 355 Leu Glu Val Wing Pro Phe Gly He Asp Val Val Val He Glu Pro Gly 70 75 80 85 j5 ate gcc acc gag tgg gga gga ate gct gct gcc gac aat etc gac gca 403 Gly He Wing Thr Glu Trp Gly Gly He Wing Wing Asp Asn Leu Asp Wing 90 95 100 gtg tcg aaa gac age gc tac aag cgc cag gct gac gc gta tcg aag 451 Val Ser Lys Asp Ser Wing Tyr Lys Arg Gln Wing Asp Wing Val Ser Lys 105 110 115 tcg ttg cga tet gag gcg aac age aac cgc aac tea cca ccg tcg gtt 499 Ser Leu Arg Ser Glu Wing Asn Ser Asn Arg Asn Ser Pro Pro Ser Val • 120 125 130 gtc gcc gat gcg att gga aag gcc gtg acg gca cgt falls ccc aag acc 547 Val Ala Asp Ala He Gly Lys Ala Val Thr Ala Arg His Pro Lys Thr 135 140 145 20 cgc tat gcc ate ttc ggt gcc aaa ccg ctg att gcc tcg cgc aac 595 Arg Tyr Wing He Gly Phe Gly Wing Lys Pro Leu He Wing Being Arg Asn 150 155 160 165 ate etc acc gat gatcg cag tcc gac cca gtg ate act cga gcg act gcc 643 He Leu Thr Asp Arg Gln Phe Asp Pro Val He Thr Arg Wing Thr Gly 170 175 180 gtc ccc cgc gac tgaccactct tctgcgcccg tea 678 Val Pro Arg Asp 185 < 210 > 112 < 211 > 185 25 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 112 Met Thr He Asp Glu Gly Arg Arg Gln Phe Glu Val Asn Val Phe Gly 1 5 10 15 Ala Met Ala Leu Thr Arg Leu Val Leu Pro His Met Gln Lys Gln Lys 20 25 30 Trp Gly Thr He Val Asn He Thr Ser Met Gly Gly Lys He Tyr Thr • 35 40 45 Pro Leu Gly Gly Trp Tyr His Gly Thr Lys Phe Ala Leu Glu Ala Leu 50 55 60 Ser Asp Ala Leu Arg Leu Glu Val Ala Pro Phe Gly He Asp Val Val 65 70 75 80 Val He Glu Pro Gly Gly He Wing Thr Glu Trp Gly Gly Wing Wing 85 90 95 Asp Asn Leu Asp Wing Val Ser Lys Asp Wing Wing Tyr Lys Arg Gln Wing 100 105 110 Asp Wing Val Ser Lys Ser Leu Arg Ser Glu Wing Asn Ser Asn Arg Asn 115 120 125 Ser Pro Pro Ser Val Val Wing Asp Wing He Gly Lys Wing Val Thr Wing 10 130 135 140 Arg His Pro Lys Thr Arg Tyr Wing He Gly Phe Gly Wing Lys Pro Leu 145 150 155 160 He Wing Being Arg Asn He Leu Thr Asp Arg Gln Phe Asp Pro Val He 165 170 175 Thr Arg Wing Thr Gly Val Pro Arg Asp 180 185 < 210 > 113 < 211 > 406 < 212 > DNA < 213 > Corynebacterium glutamicum 15 < 220 > < 221 > CDS < 222 > (101) .. (406) < 223 > FRXA02836 < 400 > 113 ccatcactcg gcttcaccgt ctacggtgct gcccgcagga cagagcgccc ccaaaagctc 60 • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • •• • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • Leu Thr 10 15 20 cga etc gtc ctg ccc falls atg cag aaa caa aag tgg ggg acg ate gtg 211 Arg Leu Val Leu Pro His Met Gln Lys Gln Lys Trp Gly Thr He Val 25 30 35 aac ate here tcg atg ggc ggg aag ate tac acg ect etc ggc ggc tgg 259 Asn He Thr Ser Met Gly Gly Lys He Tyr Thr Pro Leu Gly Gly Trp 40 45 50 tat falls ggc acc aag tc gcc etc gag gcc etc tcg gac gcc etc cgc 307 Tyr His Gly Thr Lys Phe Ala Leu Glu Ala Leu Ser Asp Ala Leu Arg 55 60 65 ctg gag gtc gcc cca ttc ggc ate gac gtt gtt gtc ate gaa ccg ggc 355 25 Leu Glu Val Ala Pro Phe Gly He Asp Val Val Val He Glu Pro Gly . .,? & ? k * 70 75 80 85 ggc ate gcc acc gag tgg gga gga ate gct gcc gac aat etc gac gca 403 Gly He Wing Thr Glu Trp Gly Gly He Wing Wing Asp Asn Leu Asp Wing 90 95 100 gtg 406 Val < 210 > 114 < 211 > 102 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 114 Met Thr He Asp Glu Gly Arg Arg Gln Phe Glu Val Asn Val Phe Gly 1 5 10 15 Ala Met Ala Leu Thr Arg Leu Val Leu Pro His Met Gln Lys Gln Lys 20 25 30 Trp Gly Thr He Val Asn He Thr Ser Met Gly Gly Lys He Tyr Thr 35 40 45 10 Pro Leu Gly Gly Trp Tyr His Gly Thr Lys Phe Ala Leu Glu Ala Leu 50 55 60 Ser Asp Ala Leu Arg Leu Glu Val Ala Pro Phe Gly He Asp Val Val 65 70 75 80 • Val He Glu Pro Gly Gly He Wing Thr Glu Trp Gly Gly He Wing Wing 85 90 95 Asp Asn Leu Asp Wing Val 100 < 210 > 115 < 211 > 1227 < 212 > DNA 15 < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1204) < 223 > RXA02578 < 400 > 115 ggcaaaaatg, agga; acagea cgcccgcaat aatgaggacc gttgcagatc < gcttcataaa 60 • aacagcccac, acctttccgc taaactcgca tgttgaaata atg tet acc acess 115 Met Ser Thr Gln Ser 1 5 20 tat gca ccc ate cgc cat cgc gga ttc ate age tea etc gag gga cta 163 Tyr Ala Pro He Arg His Arg Gly Phe He Ser Ser Leu Glu Gly Leu 10 15 20 cgc gca ate gcc tcc ctg gga gtc ttg gcg acc fall gtt gca tcc caa 211 Arg Ala He Wing Ser Leu Gly Val Leu Wing Thr His Val Wing Phe Gln 25 30 35 acc tcc gtc gac ccc gcc age aac ate ggt gca gta etc gcg cgt ttc 259 Thr Ser Val Asp Pro Wing Being Asn He Gly Wing Val Leu Wing Arg Phe 40 45 50 gac ttt ttc gtc gcc gtc ttc tcc gcc etc tcc gcc ttc gtt ctt tgg 307 Asp Phe Phe Val Wing Val Phe Phe Ala Leu Ser Ala Phe Val Leu Trp 55 60 65 25 cgc cgc cgc gcc ggg ca gca gtg gga ctg tac tac etc aaa cgc cta 355 Arg Arg Arg Ala Gly Gln Pro Val Gly Leu Tyr Tyr Leu Lys Arg Leu 70 75 80 85 gcc cgc ate atg ccc gca tac tgg gca acg gtc att gca gtc ctg ctg 403 Wing Arg He Met Pro Wing Tyr Trp Wing Thr Val He Wing Val Leu Leu 90 95 100 ttt att ccc acc ggc ccc tgg tta gcc aac ctg acg atg acc att 451 Phe He Pro Thr Gly Pro Trp Leu Ala Asn Leu Thr Met Thr Gln He 105 110 115 • tac tgg cca gac ggg etc atg here ggc etc acc fall ctt tgg tcc ctg 499 Tyr Trp Pro Asp Gly Leu Met Thr Gly Leu Thr His Leu Trp Ser Leu 120 125 130 tgc gtg gaa gtg gcg ttt tac ctg gtg atg ccg ctt etc gcg tgg gtg 547 Cys Val Glu Val Wing Phe Tyr Leu Val Met Pro Leu Leu Wing Trp Val 135 140 145 ttg gat agg ttt ggt cgg ccg gtg cgc ate ctg ttg att gtt ggt ggg 595 Leu Asp Arg Phe Gly Arg Pro Val Arg He Leu Leu He Val Gly Gly 150 155 160 165 gca gtg ttg agt ctg gcg tgg ccg tgg att ccc ctt gtg gag cat gcg 643 Wing Val Leu Ser Leu Wing Trp Pro Trp He Pro Leu Val Glu His Wing 170 175 180 10 ttg gac gag ggg tgg gcg aac atg cag ate tgg cca ccc gct tac gct 691 Leu Asp Glu Gly Trp Wing Asn Met Gln He Trp Pro Pro Wing Tyr Wing 185 190 195 tgc • tgg ttt gca gtc ggc atg ate gcc gca gaa att gaa gga gtt cga 739 Cys Tr p Phe Wing Val Gly Met He Wing Wing Glu He Glu Gly Val Arg 200 205 210 ttc cca cgg cgg gtt ccg age ttt gtg tgg gtg ggt tta gct tta gtg gtc 787 Phe Pro Arg Val Pro Ser Phe Val Trp Val Gly Leu Ala Leu Val Val 215 220 225 gct tgg ate gcg ggc caa gaa tgg ttc gga cca cta ggt tta gtg drops 835 Wing Trp He Wing Gly Gln Glu Trp Phe Gly Pro Leu Gly Leu Val His 230 235 240 245 15 ccc age ccc tgg gaa ttc aac tta aga gtc etc gcg ggc here ctt ttc 883 Pro Be Pro Tr Glu Phe Asn Leu Arg Val Leu Wing Gly Thr Leu Phe 250 255 260 gct gta ttt ctg gtg gtt ccc tac gcg ctg ggt acg ccc tet cgg ctt 931 Wing Val Phe Leu Val Val Pro Tyr Ala Leu Gly Thr Pro Be Arg Leu 265 270 275 ctt gat tcc agt tgg atg aaa acg etc ggc acc tgg tcg tat tcc ate 979 Leu Asp Be Ser Trp Met Lys Thr Leu Gly Thr Trp Ser Tyr Ser He • 280 285 290 ttc etc tgg falls ctt ccc gtg ctg acg att gtg ctc cca ctg etc ggg 1027 Phe Leu Trp His Leu Pro Val Leu Thr He Val Phe Pro Leu Leu Gly 295 300 305 20 ttg ect tta ttt agt gga aat ttc ct gtg gtg gtg tg gtg acg gtc 1075 Leu Pro Leu Phe Ser Gly Asn Phe Leu Leu Val Phe He Val Thr Val 310 315 320 325 ttg tcg tcg acc tcc gtt tcc tcc tcc tccc tcc tccc tc tcc tcc t Pro Val Ala Ala Be Ser Tyr Thr Phe He Glu Glu 330 335 340 ccc ate age ggt gga ccc ggc gcg cca tcc agg ctg ggg gtc gtt agg 1171 Pro He Ser Gly Gly Pro Gly Ala Pro Phe Arg Leu Gly Val Val Arg 345 350 355 att fall cat ttt tet ggg ggt agg tet gga aaa tgatgaattg cfcaccacgtc 1224 He His His Phe Ser Gly Gly Arg Ser Gly Lys 360 365 25 aag 1227 t 1 i l tfM¡HiMMH < 210 > 116 < 211 > 368 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 116 Met Ser Thr Gln Ser Tyr Wing Pro He Arg His Arg Gly Phe He Ser 1 5 10 15 Ser Leu Glu Gly Leu Arg Wing He Wing Being Leu Gly Val Leu Wing Thr 20 25 30 His Val Wing Phe Gln Thr Ser Val Asp Pro Wing Being Asn He Gly Wing 35 40 45 Val Leu Wing Arg Phe Asp Phe Phe Val Wing Val Phe Phe Wing Leu Ser 50 55 60 Wing Phe Val Leu Trp Arg Arg Arg Wing Gly Gln Pro Val Gly Leu Tyr 65 70 75 80 Tyr Leu Lys Arg Leu Wing Arg He Met Pro Wing Tyr Trp Wing Thr Val 85 90 95 Wing Wing Val Leu Leu Phe He Pro Thr Gly Pro Trp Leu Wing Asn Leu 100 105 110 Thr Met Thr Gln He Tyr Trp Pro Asp Gly Leu Met Thr Gly Leu Thr 115 120 125 His Leu Trp Ser Leu Cys Val Glu Val Ala Phe Tyr Leu Val Met Pro 130 135 140 Leu Leu Ala Trp Val Leu Asp Arg Phe Gly Arg Pro Val Arg He Leu 145 150 155 160 Leu He Val Gly Gly Ala Val Leu Ser Leu Wing Trp Pro Trp He Pro 165 170 175 Leu Val Glu His Wing Leu Asp Glu Gly Trp Wing Asn Met Gln He Trp 180 185 190 Pro Pro Wing Tyr Wing Cys Trp Phe Wing Val Gly Met He Wing Wing Glu 195 200 205 He Gl u Gly Val Arg Phe Pro Arg Val Pro Ser Phe Val Trp Val Gly 210 215 220 Leu Ala Leu Val Val Ala Trp He Ala Gly Gln Glu Trp Phe Gly Pro 225 230 235 240 Leu Gly Leu Val His Pro Ser Pro Trp Glu Phe Asn Leu Arg Val Leu 245 250 255 Wing Gly Thr Leu Phe Wing Val Phe Leu Val Val Pro Tyr Wing Leu Gly 260 265 270 Thr Pro Ser Arg Leu Leu Asp Ser Being Trp Met Lys Thr Leu Gly Thr 275 280 285 Trp Ser Tyr Ser He Phe Leu Trp His Leu Pro Val Leu Thr He Val 290 295 300 Phe Pro Leu Leu Gly Leu Pro Leu Phe Ser Gly Asn Phe Leu Leu Val 305 310 315 320 Phe He Val Thr Val Leu Leu Thr He Pro Val Ala Wing He Ser Tyr 325 330 335 Thr Phe He Glu Glu Pro He Gly Gly Pro Gly Pro Pro Phe Arg 340 345 350 Leu Gly Val Val Arg He His Phe Ser Gly Gly Arg Ser Gly Lys 355 360 365 < 210 > 117 < 211 > 924 < 212 > DNA JL? K * l. ± < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (901) < 223 > RXA02150 < 400 > 117 gtgtttttcg < gtgggctgt; g atgacgcatg tccaccaaaa gagecací CCC "ttaaagaaat 60 taaaaagtgg 1ttttggtagc ttegeagea; a aatacacatc gtg ggt aac gta ttc 115 Val Gly Asn Val Phe 1 5 tta gaa gtt ect here gca gta aag cgc gaa gaa ggg gta aac cca aac 163 Leu Glu Val Pro Thr Wing Val Lys Arg Glu Glu Gly Val Asn Pro Asn 10 15 20 tet atg aaa aac aac tgg tat cgg ctt ttc aag tat gtg cta att ggc 211 He Met Lys Asn Asn Trp Tyr Arg Leu Phe Lys Tyr Val Leu He Gly 25 30 35 ccg ttt ttg cgt gtg tac aac cgc ccg gag ate gaa ggc aaa gaa aac 259 Pro Phe Leu Arg Val Tyr Asn Arg Pro Glu He Glu Gly Lys Glu Asn 40 45 50 ate ect gca gag ggt gcc gcg ate atg gcg tcc aac cae gaa gca gtg 307 He Pro Wing Glu Gly Wing Wing He Met Wing Wing Asn His Glu Wing Val 55 60 65 atg gat tcc ttt tat ttt ccc ctg ctg tgc cca cgg cag ctg acc ttc 355 Met Asp Ser Phe Tyr Phe Pro Leu Leu Cys Pro Arg Gln Leu Thr Phe 70 75 80 85 cca gcg aag gcc gaa tac ttc here tea cca ggt att aaa ggc aag atg 403 Pro Ala Lys Ala Glu Tyr Phe Thr Ser Pro Gly He Lys Gly Lys Met 90 95 100 cag aag tgg ttt ttt act tet gtg ggg ca gta ccc ctg gac cgc acc 451 Gln Lys Trp Phe Phe Thr Ser Val Gly Gln Val Pro Leu Asp Arg Thr 105 110 115 gca gat aat gcc atg gat tet ttg atg aat acc gcc aaa atg gtg ctg 499 Wing Asp Asn Wing Met Asp Ser Leu Met Asn Thr Wing Lys Met Val Leu 120 125 130 gat cgg gga gac etc ttc ggt att tac ect gaa gga tet cgt tcg ccc 547 Asp Arg Gly Asp Leu Phe Gly He Tyr Pro Glu Gly Ser Arg Ser Pro 135 140 145 gat ggt cgc ate tac aag ggc aaa acc gga atg gcc tat gtt gcg atg 595 Asp Gly Arg He Tyr Lys Gly Lys Thr Gly Met Wing Tyr Val Wing Met 150 155 160 165 gaa act ggt acg here gtt ate ccc gtt gcc atg att ggc age cgg gac 643 Glu Thr Gly Thr Thr Val He Pro Val Wing Met He Gly Ser Arg Asp 170 175 180 gcg aac ect ate gga agt tgg ttt ccg aaa ccc gca aaa gtc agg ate 691 Wing Asn Pro He Gly Ser Trp Phe Pro Lys Pro Wing Lys Val Arg He 185 190 195 aag gta age cca att gat ccc etc gca ttc gtc aaa gaa cat ggg 739 Lys Val Gly Pro Pro He Asp Pro Leu Wing Phe Val Lys Glu His Gly 200 205 210 ttg aag ect gga acc tac gaa gca gcg cgc aag ctg here gat gtt 787 Leu Lys Pro Gly Thr Tyr Glu Wing Wing Arg Lys Leu Thr Asp His Val 215 220 225 atg ttc att ctt gct gat etc act ggt cag ccg tat gtt qat gcg tac 835 Met Phe He Leu Wing Asp Leu Thr Gly Gln Pro Tyr Val Asp Wing Tyr 230 235 240 245 tet aaa gat gtg aaa aac gct ctg gag gaga gga aaa gga tac ccg gag 883 Ser Lys Asp Val Lys Asn Ala Leu Glu Glu Gly Lys Gly Tyr Pro Glu 250 255 260 ggc here gct ect tea cag taatcgggtc ttttctgtta aaa 924 Gly Thr Ala Pro Ser Gln 265 < 210 > 118 < 211 > 267 • < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 118 Val Gly Asn Val Phe Leu Glu Val Pro Thr Ala Val Lys Arg Glu Glu 1 5 10 15 Gly Val Asn Pro Asn He Met Lys Asn Asn Trp Tyr Arg Leu Phe Lys 20 25 30 Tyr Val Leu He Gly Pro Phe Leu Arg Val Tyr Asn Arg Pro Glu He 35 40 45 Glu Gly Lys Glu Asn He Pro Wing Glu Gly Wing Wing He Met Wing Ser 10 50 55 60 Asn His Glu Wing Val Met Asp Ser Phe Tyr Phe Pro Leu Leu Cys Pro 65 70 75 80 Arg Gln Leu Thr Phe Pro Wing Lys Wing Glu Tyr Phe Thr Ser Pro Gly • 85 90 95 He Lys Gly Lys Met Gln Lys Trp Phe Phe Thr Ser Val Gly Gln Val 100 105 110 Pro Leu Asp Arg Thr Wing Asp Asn Wing Met Asp Ser Leu Met Asn Thr 115 120 125 Wing Lys Met Val Leu Asp Arg Gly Asp Leu Phe Gly He Tyr Pro Glu 130 135 140 Gly Ser Arg Ser Pro Asp Gly Arg He Tyr Lys Gly Lys Thr Gly Met 15 145 150 155 160 Wing Tyr Val Wing Met Glu Thr Gly Thr Thr Val He Pro Val Wing Met 165 170 175 He Gly Ser Arg Asp Wing Asn Pro He Gly Ser Trp Phe Pro Lys Pro 180 185 190 Wing Lys Val Arg He Lys Val Gly Ser Pro He Asp Pro Leu Wing Phe 195 200 05 Val Lys Glu His Gly Leu Lys Pro Gly Thr Tyr Glu Ala Wing Arg Lys * 210 215 220 Leu Thr Asp His Val Met Phe He Leu Wing Asp Leu Thr Gly Gln Pro 225 230 235 240 Tyr Val Asp Wing Tyr Ser Lys Asp Val Lys Asn Ala Leu Glu Glu Gly 20 245 250 255 Lys Gly Tyr Pro Glu Gly Thr Ala Pro Ser Gln 260 265 < 210 > 119 < 211 > 504 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (481) 25 < 223 > RXA00607 < 400 > 119 cactgccagc; aacgccaat; g gttgaacceg aaccagaagg cgatgaagac tggcccgaac 60 ccatcaaccc < Dgcaggcgat aacaaagagg aggcaaaccg atg att etc gca ctg 115 Met He Leu Ala Leu 1 5 here gtc gcg ata ctt ttc ggt ggt ggt gtc tac etc att cag cag cgc 163 Thr Val Ala He Leu Phe Gly Gly Gly Val Tyr Leu He Gln Gln Arg 10 15 20 gga atg gtg cgc ate gtc ttc ggc atg tea ctg ate ggc falls gca gcg 211 Gly Met Val Arg He Val Phe Gly Met Ser Leu He Gly His Ala Wing 25 30 35 aac ctg acc ate ctg tac gcc ggt gtg ccc acg tgg cgc ggc gaa gcc 259 Asn Leu Thr He Leu Tyr Wing Gly Val Pro Thr Trp Arg Gly Glu Wing 40 45 50 ttc ccc gac agg acc ccg ctt acc gac gcc gcc gat cca etc ccc cag 307 Phe Pro Asp Arg Thr Pro Leu Thr Asp Wing Wing Asp Pro Leu Pro Gln 55 60 65 gcc ttc gtc etc acc gcc gtc ate gcg gtg atg acc acc acc ate 355 Wing Phe Val Leu Thr Wing He Val He Wing Met Wing Thr Thr Thr He 10 70 75 80 85 atg ttg gcc ttg gca gca ctg gga cgc age gac gac acc cgg tcc ate 403 Met Leu Ala Leu Ala Ala Leu Gly Arg Ser Asp Asp Thr Arg Ser He • 90 95 100 gaa cca gat gac gat cac tcg ect ttg act act age gct cgt tea gtc 451 Glu Pro Asp Asp Asp Gln Ser Pro Leu Thr Thr Ser Wing Arg Ser Val 105 110 115 acc aac cca here gat cag gag gat aaa gct taaatggcca tggatgttct 501 Thr Asn Pro Thr Asp Gln Glu Asp Lys Wing 120 125 ect 504 15 < 210 > 120 < 211 > 127 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 120 Met He Leu Ala Leu Thr Val Ala He Leu Phe Gly Gly Gly Val Tyr 1 5 10 15 • Leu He Gln Gln Arg Gly Met Val Arg He Val Phe Gly Met Ser Leu 20 25 30 He Gly His Ala Ala Asn Leu Thr He Leu Tyr Wing Gly Val Pro Thr 35 40 45 2Q Trp Arg Gly Glu Wing Phe Pro Asp Arg Thr Pro Leu Thr Asp Wing Wing 50 55 60 Asp Pro Leu Pro Gln Wing Phe Val Leu Thr Wing He Val He Wing Met 65 70 75 80 Wing Thr Thr Thr He Met Leu Wing Leu Wing Wing Leu Gly Arg Being Asp 85 90 95 Asp Thr Arg Being He Glu Pro Asp Asp Asp Gln Ser Pro Leu Thr Thr 100 105 110 Being Wing Arg Being Val Thr Asn Pro Thr Asp Gln Glu Asp Lys Ala 115 120 125 < 210 > 121 25 < 211 > 1119t? . < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1096) < 223 > RXA02397 < 400 > 121 gtgtgaa "taa, aacttgtttc ctggtieattt cccctactga actgcgctta • tgec-tatget 60 tagaaaccag, agacaagett aagaaiggaca ggggccggcc atg aat gat ttc gaa 115 Met Asn Asp Phe Glu 1 5 here acc ate gat cgg ate tet aaa gaa ca a gat ccc gca gcc cga age 163 Thr Thr He Asp Arg He Ser Lys Glu Gln Asp Pro Wing Ala Arg Ser 10 15 20 cgc gtg gaa cag ttc att gtg gaa here gta cgt gca cta ccc aac ttg 211 Arg Val Glu Gln Phe He Val Glu Thr Val Arg Ala Leu Pro Asn Leu 25 30 35 acc ac aaa ca ggt gca tcg ttg gct ate ca ctt ctt gat gcg gta 259 10 Thr Thr Lys Gln Gly Wing Ser Leu Wing He Gln Leu Leu Asp Wing Val 40 45 50 cag etc gcg gat gcg gcg gga acc aag ggg gcg tcg here age aat 307 • Gln Leu Wing Asp Wing Wing Gly Thr Lys Gly Gly Wing Being Thr Ser Asn 55 60 65 gct tea tcg ctg ect gac acc ttt gac gcg ctg acc age ctg att ggc 355 Wing Being Ser Leu Pro Asp Thr Phe Asp Wing Leu Thr Ser Leu He Gly 70 75 80 85 aag etc gat gtg cgc age gat tet gaa tgg cgc tcg ttt ggg ttc cag 403 Lys Leu Asp Val Arg Ser Asp Ser Glu Trp Arg Ser Phe Gly Phe Gln 90 95 100 ect tet gaa act gcg cae ccg cta atg ate gct ate ect gag att gag 451 15 Pro Ser Glu Thr Wing His Pro Leu Met He Wing He Pro Glu He Glu 105 110 115 att ttt tat cag drops gat gtg gag ccg gga age gat gac gcc gtg 499 He Phe Tyr Gln His Thr Asp Val Glu Pro Gly Ser Asp Asp Ala Val 120 125 130 gcg ccg gac ttt cag gaa aat cag gat atg tgg cgc agg cgt etc gga 547 Wing Pro Asp Phe Gln Glu Asn Gln Asp Met Trp Arg Arg Arg Leu Gly 135 140 145 • tet gtc acc gaa cca aac ctt ata tat aaa gag ttt ccc gga ccc ggc 595 Ser Val Thr Glu Pro Asn Leu He Tyr Lys Glu Phe Ser Gly Pro Gly 150 155 160 165 aaa gcg cag cgt gcc gta gaa atg ctg ggc aat ctg tgg aag ate ggc 643 20 Lys Ala Gln Arg Ala Val Glu Met Leu Gly Asn Leu Trp > Lys He Gly 170 175 180 gtg gtg gtg agt agg aat acg gaa agt cgc ctt ggg tta act cgt gtg 691 Val Val Val Ser Arg Asn Thr Glu Ser Arg Leu Gly Leu Thr Arg Val 185 190 195 gaa tac acc ccc acc ect ggc gaa gta ccc gtg ccg ctg atg tcg gag 739 Glu Tyr Thr Pro Thr Pro Gly Glu Val Pro Pro Leu Met Ser Glu 200 205 210 aag aac tgt tgg tac age att cgg gtg tet gaa acc att ggt gag aac 787 Lys Asn Cys Trp Tyr Ser He Arg Val Ser Glu Thr He Gly Glu Asn 215 220 225 cag gtt ccg gaa att gtg cgc tgc tta ggc gag att ttc tgt ggc tat 835 25 Gln Val Pro Glu He Val Arg Cys Leu Gly Glu He Phe Cys Gly Tyr 230 235 240 245 ctt ccc cag atg tgg etc aaa gaa cca gta aag gcc ggc aag ttg cga 883 Leu Pro Gln Met Trp Leu Lys Glu Pro Val Lys Ala Gly Lys Leu Arg 250 255 260 ate caa gaa tcg gaa gca gca gcg tat ate gcg atg gcg cga cta gat 931 He Gln Glu Ser Glu Ala Ala Ala Tyr He Ala Met Ala Ala Arg Leu Asp 265 270 275 ctt tcc cca cgc acc ggc aac acc act tgg acc aac age tat att 979 Leu Ser Pro Arg Thr Gly Asn Thr Thr Trp Thr Asn Ser Tyr He Ser • 280 285 290 acg cgt ect etc tcc ccc gct ttt agg tgg gac gtg gtg ctg gag gct 1027 Thr Arg Pro Leu Ser Pro Wing Phe Arg Trp Asp Val Val Leu Glu Wing 295 300 305 tcc falls cag ttg gag aac ctg cgt gga gac ac ggg ccg gtc act 1075 Ser His Gln Leu Glu Asn Leu Leu Arg Gly Asp Thr Gly Pro Val Thr 310 315 320 325 gcc here caá tcg gca gct ggt taaccaaaag ttcacgtgga gat 1119 Ala Thr Gln Ser Ala Ala Gly 330 10 < 210 > 122 < 211 > 332 < 212 > PRT < 213 > Corynebacterium glutamicum • < 400 > 122 Met Asn Asp Phe Glu Thr Thr He Asp Arg He Ser Lys Glu Gln Asp 1 5 10 15 Pro Wing Wing Arg Being Arg Val Glu Gln Phe He Val Val Thu Val Arg 20 25 30 Wing Leu Pro Asn Leu Thr Thr Lys Gln Gly Ala Ser Leu Ala He Gln 35 40 45 15 Leu Leu Asp Ala Val Gln Leu Ala Asp Ala Ala Gly Thr Lys Gly Gly 50 '55 60 Wing Ser Thr Ser Asn Ala Ser Ser Leu Pro Asp Thr Phe Asp Ala Leu 65 70 75 80 Thr Ser Leu He Gly Lys Leu Asp Val Arg Ser Asp Ser Glu Trp Arg 85 90 95 Ser Phe Gly Phe Gln Pro Ser Glu Thr Ala His Pro Leu Met He Wing 100 105 110 He Pro Glu He Glu He Phe Tyr Gln His Thr Asp Val Glu Pro Gly 115 120 125 Ser Asp Asp Ala Val Ala Pro Asp Phe Gln Glu Asn Gln Asp Met Trp 130 135 140 20 Arg Arg Arg Leu Gly Ser Val Thr Glu Pro Asn Leu He Tyr Lys Glu 145 150 155 160 Phe Ser Gly Pro Gly Lys Wing Gln Arg Wing Val Glu Met Leu Gly Asn 165 170 175 Leu Trp Lys He Gly Val Val Val Ser Arg Asn Thr Glu Ser Arg Leu 180 185 190 Gly Leu Thr Arg Val Glu Tyr Thr Pro Thr Pro Gly Glu Val Pro Val 195 200 205 Pro Leu Met Ser Glu Lys Asn Cys Trp Tyr Ser He Arg Val Ser Glu 210 215 220 Thr He Gly Glu Asn Gln Val Pro Glu He Val Arg Cys Leu Gly Glu 225 230 235 240 2 He Phe Cys Gly Tyr Leu Pro Gln Met Trp Leu Lys Glu Pro Val Lys 245 250 255 Wing Gly Lys Leu Arg He Gln Glu Ser Glu Wing Wing Tyr He Ala Wing 260 265 270 Met Wing Arg Leu Asp Leu Ser Pro Arg Thr Gly Asn Thr Thr Trp Thr 275 280 285 Asn Ser Tyr He Ser Thr Arg Pro Leu Ser Pro Wing Phe Arg Trp Asp 290 295 300 Val Val Leu Glu Wing Ser His Gln Leu Gl u Asn Leu Leu Arg Gly Asp • 305 310 315 320 Thr Gly Pro Val Thr Ala Thr Gln Ser Ala Ala Gly 325 330 <; 210 > 123 < 211 > 1462 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1462) 10 < 223 > RXN03110 < 400 > 123 aatgagtgaa < cctgtegcttg aactataccc ectggggtat tadtgtagat 1üetcaata ccg¡aggggta itetatgttttt acgttgaga; a ggagagetca gtg ctt att gaa cgc 115 Val Leu He Glu Arg 1 5 ate tac gac gac ctt gcg cag gcc age tat ttc att ggc tgc caa 163 He Tyr Asp Glu Asp Leu Ala Gln Ala Ser Tyr Phe He Gly Cys Gln 10 15 20 gcc falls aac ac gc gtc gtg gat ccg cgc cgc gat gcc att gtc 211 Ala His Asn Thr Ala Val Val Val Asp Pro Arg Arg Asp He Ala Val 15 25 30 35 tat ctg gac atg gcc aag aaa aac gga atg gag att gtt gga gtt acc 259 Tyr Leu Asp Met Wing Lys Lys Asn Gly Met Glu He Val Gly Val Thr 40 45 50 gaa acc cat ate cat gcg gac tat ttg tea gga acc cgt gag tta gct 307 Glu Thr His He His Wing Asp Tyr Leu Ser Gly Thr Arg Glu Leu Wing 55 60 65 gct gca act aat gcc acc atg tac gtc tea ggg gag ggc ggc gcc gat 355• Wing Wing Thr Asn Wing Thr Met Tyr Val Ser Gly Glu Gly Gly Wing Asp 70 75 80 85 tgg cag tat gaa ttc gac gcc gag cga ata tgc gac ggc age gag att 403 Trp Gln Tyr Glu Phe Asp Wing Glu Arg He Cys Asp Gly Ser Glu He is 20 90 95 100 cgc ctg gga aat ctg gtg etc here gct gtt falls acc cca ggc cat acc 451 Arg Leu Gly Asn Leu Val Leu Thr Ala Val His Thr Pro Gly His Thr 105 110 115 ccg gaa falls tta tcg ttc ctg ctg aag gac ggc gcg gcg gt gat gag 499 Pro Glu His Leu Ser Phe Leu Leu Lys Asp Gly Wing Phe Wing Asp Glu 120 125 130 cca gga ttc atg etc act ggc gat ttc gtt ttc gcg ggt gat ctt ggc 547 Pro Gly Phe Met Leu Thr Gly Asp Phe Val Phe Wing Gly Asp Leu Gly 135 140 145 cga cca gat ttg etc gat gaa gca gct ggg gga gtg gac act cgt ttt 595 Arg Pro Asp Leu Leu Asp Glu Wing Wing Gly Gly Val Asp Thr Arg Phe 25 150 155 160 165 i_-j.-i gag ggg gct cgc cag atg ttc aag age ttg aag gaa aaa ttc ctg here 643 Glu Gly Ala Arg Gln Met Phe Lys Ser Leu Lys Glu Lys Phe Leu Thr 170 175 180 ttg ect gat cae ate cag ate ttc ect ggt cat ggt tcc ggt tcc gcg 691 Leu Pro Asp His He Gln He Phe Pro Gly His Gly Ser Gly Ser Wing 185 190 195 tgt ggc aaa gcc ttg ggt tcg gtt ect tea here ctt gga tat gaa 739 Cys Gly Lys Ala Leu Gly Ser Val Pro Ser Thr Thu Leu Gly Tyr Glu F 200 205 210 ct gt gtg tgg ggg tgg ggg aga gt gg cat gat gat gaa ca 787 Arg Gln Phe Wing Trp Trp Gly Lys Tyr Leu Glu Wing Asp Asp Glu Gln 215 220 225 gga ttc att gat gag ctt ctg gaa ggc caa ect gat gca ect gca tac 835 Gly Phe He Asp Glu Leu Glu Glu Gln Pro Asp Wing Pro Wing Tyr 230 235 240 245 ttc ggc agg atg aag agg caa aat agg caa ggg ccc gca att atg ggc Phe Gly Arg Met Lys Arg Gln Asn Arg Gln Gly Pro Wing He Met Gly 250 255 260 gct cgc gag ctg ttg cca cag ctg gaa gct tet gat ctg cae gac gtc 931 Wing Arg Glu Leu Pro Gln Leu Glu Ala Ser Asp Leu His Asp Val 10 265 270 275 att gtt gtt gat acc cgc tea gcc gat gaa gtt falls cag ggc act gta 979 He Val Val Asp Thr Arg Ser Wing Asp Glu Val His Gln Gly Thr Val 280 285 290 • gct ggt gca gtg aat att cet gcg ggc aat tcg atg gcg aaa ttt ggc 1027 Wing Gly Wing Val Asn He Pro Wing Gly Asn Ser Met Wing Lys Phe Gly 295 300 305 tcg tgg ggg gat ccc gag aag gat tcc cg gct ttg gtt ctg etc 1075 Ser Trp Thr Val Asp Pro Glu Lys Asp Ser Arg Wing Leu Val Leu Leu 310 315 320 325 gcg gca age ca gt ggt gcc atg gag atg tgg gac falls atg gtt cgc 1123 Wing Wing Gln He Gly Wing Met Glu Met Trp Asp His Met Val Arg 15 330 335 340 gtg gga ate gat aat gtt ggt ttt ate acc aac ttt gat ggg gtg 1171 Val Gly He Asp Asn Val Wing Gly Phe He Thr Asn Phe Asp Gly Val 345 350 355 gac cta gtt gca ccg caà act gtg tcc cca gat cag ctg gat gaa ttg 1219 Asp Leu Val Wing Pro Gln Thr Val Ser Pro Asp Gln Leu Asp Glu Leu 360 365 370 gaa tac gat cta ctt ctt gat gtc cgc aac cgc agt gaa gt c gaa gaa 1267 • Glu Tyr Asp Leu Leu Leu Asp Val Arg Asn Arg Ser Glu Val Glu Glu 375 380 385 ggc tac ate cca gga gca etc cat att aat ggt gca tcc gtg ctg tgg 1315 Gly Tyr He Pro Gly Ala Leu His He Asn Gly Wing Val Leu Trp 20 390 395 400 405 aat ctg gag aaa ctg cca cgt gac gga aag ate gtg age tac tgc aag 1363 Asn Leu Glu Lys Leu Pro Arg Asp Gly Lys He Val Ser Tyr Cys Lys 410 415 420 agt gga here cgc age tea ate gcc gca age acc ctg cgt aat gct ggt 1411 Ser Gly Thr Arg Being Ser Wing Wing Ser Thr Leu Arg Asn Wing Gly 425 430 435 ttt gat gtg gtg gaa ctt ca gga tcc tat gac aac tgg gtc cgg drops 1459 Phe Asp Val Val Glu Leu Gln Gly Ser Tyr Asp Asn Trp Val Arg His 440 445 450 aac 1462 Asn 25 ^ "K. , ^^^^ < 210 > 124 < 211 > 454 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 124 Val Leu He Glu Arg He Tyr Asp Glu Asp Leu Wing Gln Wing Being Tyr 1 5 10 15 Phe He Gly Cys Gln Wing His Asn Thr Wing Val Val Val Asp Pro Arg 20 25 30 Arg Asp He Wing Val Tyr Leu Asp Met Wing Lys Lys Asn Gly Met Glu 35 40 45 He Val Gly Val Thr Glu Thr His He His Wing Asp Tyr Leu Ser Gly 50 55 60 Thr Arg Glu Leu Wing Wing Thr Asn Wing Thr Met Tyr Val Ser Gly 65 70 75 80 Glu Gly Gly Wing Asp Trp Gln Tyr Glu Phe Asp Wing Glu Arg He Cys 85 90 95 Asp Gly Ser Glu He Arg Leu Gly Asn Leu Val Leu Thr Wing Val His 100 105 110 10 Thr Pro Gly His Thr Pro Glu His Leu Ser Phe Leu Leu Lys Asp Gly 115 120 125 • Wing Phe Wing Asp Glu Pro Gly Phe Met Leu Thr Gly Asp Phe Val Phe 130 135 140 Wing Gly Asp Leu Gly Arg Pro Asp Leu Leu Asp Glu Wing Wing Gly Gly 145 150 155 160 Val Asp Thr Arg Phe Glu Gly Wing Arg Gln Met Phe Lys Ser Leu Lys 165 170 175 Glu Lys Phe Leu Thr Leu Pro Asp His He Gln He Phe Pro Gly His 180 185 190 Gly Ser Gly Ser Ala Cys Gly Lys Ala Leu Gly Ser Val Pro Ser Thr 15 195 200 205 Thr Leu Gly Tyr Glu Arg Gln Phe Wing Trp Trp Gly Lys Tyr Leu Glu 210 215 220 Wing Asp Asp Glu Gln Gly Phe He Asp Glu Leu Leu Glu Gly Gln Pro 225 230 235 240 Asp Wing Pro Wing Tyr Phe Gly Arg Met Lys Arg Gln Asn Arg Gln Gly 245 250 255 Pro Wing He Met Gly Wing Arg Glu Leu Leu Pro Gln Leu Glu Wing Ser • 260 265 270 Asp Leu His Asp Val He Val Val Asp Th r Arg Ser Wing Asp Glu Val 275 280 285 His Gln Gly Thr Val Wing Gly Wing Val Asn He Pro Wing Gly Asn Ser 20 290 295 300 Met Wing Lys Phe Gly Ser Trp Thr Val Asp Pro Glu Lys Asp Ser Arg 305 310 315 320 Ala Leu Val Leu Leu Ala Ala Ser Gln He Gly Ala Met Glu Met Trp 325 330 335 Asp His Met Val Arg Val Gly He Asp Asn Val Wing Gly Phe He Thr 340 345 350 Asn Phe Asp Gly Val Asp Leu Val Wing Pro Gln Thr Val Ser Pro Asp 355 360 365 Gln Leu Asp Glu Leu Glu Tyr Asp Leu Leu Leu Asp Val Arg Asn Arg 370 375 380 Ser Glu Val Glu Glu Gly Tyr He Pro Gly Ala Leu His He Asn Gly 25 385 390 395 400 fc «d Aa £ -á .-? «^ G? - & ^ * # ^ ^ ¿^ ** fc * fcjfaJ Ala Ser Val Leu Trp Asn Leu Glu Lys Leu Pro Arg Asp Gly Lys He 405 410 415 Val Ser Tyr Cys Lys Ser Gly Thr Arg Ser Ser He Wing Wing Ser Thr 420 425 430 Leu Arg Asn Wing Gly Phe Asp Val Val Glu Leu Gln Gly Ser Tyr Asp 435 440 445 Asn Trp Val Arg His Asn 450 5 < 210 > 125 < 211 > 1023 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (1023) < 223 > FRXA00660 < 400 > 125 JO cea ggc cat acc ccg gaa cae tta tcg ttc ctg ctg aag gac ggc gcg 48 Pro Gly His Thr Pro Glu His Leu Ser Phe Leu Leu Lys Asp Gly Wing 1 5 10 15 ttc gca cat gag cca gga ttc atg etc act ggc gat ttc gtt tcc gcg 96 Phe Wing His Glu Pro Gly Phe Met Leu Thr Gly Asp Phe Val Phe Wing 20 25 30 ggt gat ctt ggc cga cca gat ttg etc gat gaa gca gct ggg gga gtg 144 Gly Asp Leu Gly Arg Pro Asp Leu Leu Asp Glu Wing Wing Gly Gly Val 35 40 45 gac act cgt ttt gag ggg gct cgc cag atg ttc aag age ttg aag gaa 192 Asp Thr Arg Phe Glu Gly Wing Arg Gln Met Phe Lys Ser Leu Lys Glu 50 55 60 5 aaa ttc ctg here ttg ect gat gat ate ateg ttc ect ggt cat ggt 240 Lys Phe Leu Thr Leu Pro Asp His He Gln He Phe Pro Gly His Gly 65 70 75 80 tcc ggt tcc gcg tgt ggc aaa gcc ttg ggt tcg gtt ect tea here 288 Be Gly Be Wing Cys Gly Lys Wing Leu Gly Ser Val Pro Be Thr Thr 85 90 95 ctt gga tat gaa cgt caà ttt gcg tgg tgg gga aag tat ctg gag gca 336 Leu Gly Tyr Glu Arg Gln Phe Wing Trp Trp Gly Lys Tyr Leu Glu Wing 100 105 110 gat gat gaa ca gga ttc att gat gag ctt ctg gaa ggc caa ect gat 384 Asp Asp Glu Gln Gly Phe He Asp Glu Leu Leu Glu Gly Gln Pro Asp 115 120 125 20 gca ect gca tac tc ggc agg atg aag agg caa aat agg caa ggg ccc 432 Wing Pro Wing Tyr Phe Gly Arg Met Lys Arg Gln Asn Arg Gln Gly Pro 130 135 140 gca att atg ggc gct cgc gag ctg ttg cca cag ctg gaa gct tet gat 480 Wing He Met Gly Wing Arg Glu Leu Leu Pro Gln Leu Glu Wing Being Asp 145 150 155 160 ctg falls gac gtc att gtt gtt gat acc cgc tea gcc gat gaa gtt falls 528 Leu His Asp Val He Val Val Asp Thr Arg Ser Wing Asp Glu Val His 165 170 175 cag ggc act gta gct ggt gca gtg aat att ect gcg ggc aat tcg atg 576 Gln Gly Thr Val Wing Gly Wing Val Asn He Pro Wing Gly Asn Ser Met 180 185 190 25 gcg aaa ttt ggc tcg tgg acc gtt gat ccc gag aag gat ccc gct 624 jj ^ "J ** fíMpf? ^? rif Wing Lys Phe Gly Ser Trp Thr Val Asp Pro Glu Lys Asp Ser Arg Wing 195 200 205 ttg gtt ctg etc gcg gca age ca gt att ggt gcc atg gag atg tgg gac 672 Leu Val Leu Leu Wing Wing Gln He Gly Wing Met Glu Met Trp Asp 210 215 220 fall atg gtt cgc gtg gga ate gat aat gtt gct gtt ttt ate acc aac 720 His Met Val Arg Val Gly He Asp Asn Val Wing Gly Phe He Thr Asn 225 230 235 240 • ttt gat ggg gtg gac cta gtt gcc ccg caa act gtg tcc cca gat cag 768 Phe Asp Gly Val Asp Leu Val Wing Pro Gln Thr Val Ser Pro Asp Gln 245 250 255 ctg gat gaa ttg gaa tac gat cta ctt ctt gat gtc cgc aac cgc agt 816 Leu Asp Glu Leu Glu Tyr Asp Leu Leu Leu Asp Val Arg Asn Arg Ser 260 265 270 gaa gtc gaa ggc tac ate cca gga gca etc cat att aat ggt gca 864 Glu Val Glu Glu Gly Tyr He Pro Gly Ala Leu His He Asn Gly Wing 275 280 285 tcc gtg ctg tgg aat ctg gag aaa ctg cca cgt gac gga aag ate gtg 912 Ser Val Leu Trp Asn Leu Glu Lys Leu Pro Arg Asp Gly Lys He Val 290 295 300 10 age tac tgc aag agt gga here cgc age tea gcc gca age acc ctg 960 Ser Tyr Cys Lys Ser Gly Thr Arg Ser Ser Wing Wing Ser Thr Leu 305 310 315 320 • cgt aat gct ggt ttt gat gtg gtg gaa ctt ca gga tcc tat gac aac 1008 Arg Asn Wing Gly Phe Asp Val Val Glu Leu Gln Gly Ser Tyr Asp Asn 325 330 335 tgg gtc cgg falls aac 1023 Trp Val Arg His Asn 340 < 210 > 126 < 211 > 341 15 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 126 Pro Gly His Thr Pro Glu His Leu Ser Phe Leu Leu Lys Asp Gly Wing 1 5 10 15 Phe Wing His Glu Pro Gly Phe Met Leu Thr Gly Asp Phe Val Phe Wing 20 25 30 • Gly Asp Leu Gly Arg Pro Asp Leu Leu Asp Glu Ala Ala Gly Gly Val 35 40 45 Asp Thr Arg Phe Glu Gly Wing Arg Gln Met Phe Lys Ser Leu Lys Glu 50 55 60 2Q Lys Phe Leu Thr Leu Pro Asp His He Gln He Phe Pro Gly His Gly 65 70 75 80 Ser Gly Ser Ala Cys Gly Lys Wing Leu Gly Ser Val Pro Ser Thr Thr 85 90 95 Leu Gly Tyr Glu Arg Gln Phe Wing Trp Trp Gly Lys Tyr Leu Glu Wing 100 105 110 Asp Asp Glu Gln Gly Phe He Asp Glu Leu Glu Glu Gln Pro Asp 115 120 125 Wing Pro Wing Tyr Phe Gly Arg Met Lys Arg Gln Asn Arg Gln Gly Pro 130 135 140 Wing He Met Gly Wing Arg Glu Leu Leu Pro Gln Leu Glu Wing As Asp 145 150 155 160 25 Leu His Asp Val He Val Val Asp Thr Arg Ser Wing Asp Glu Val His tA sl!? i) Í.Jt *? .ttí? í & ..u .. á _ "., __, _.__ ..,., ..,., .., _______:., .. ,,". . . -: ___., • ._..-. .,., "__.._ ,, __, .__, .._,".,. N-irf, .- ,. . "__.___ ___., _ _,. - .. ,,,. , _ ,, __ > , -_ > . { _, 8._a. 165 170 175 Gln Gly Thr Val Wing Gly Wing Val Asn He Pro Wing Gly Asn Ser Met 180 185 190 Wing Lys Phe Gly Ser Trp Thr Val Asp Pro Glu Lys Asp Ser Arg Wing 195 200 205 Leu Val Leu Leu Wing Wing Gln He Gly Ala Met Glu Met Trp Asp 210 215 220 His Met Val Arg Val Gly He Asp Asn Val Wing Gly Phe He Thr Asn 225 230 235 240 Phe Asp Gly Val Asp Leu Val Ala Pro Gln Thr Val Ser Pro Asp Gln 245 250 255 Leu Asp Glu Leu Glu Tyr Asp Leu Leu Asu Val Arg Asn Arg Ser 260 265 270 Glu Val Glu Glu Gly Tyr He Pro Gly Ala Leu His He Asn Gly Ala 275 280 285 Ser Val Leu Trp Asn Leu Glu Lys Leu Pro Arg Asp Gly Lys He Val 290 295 300 Ser Tyr Cys Lys Ser Gly Thr Arg Ser Ser Wing Wing Ser Thr Leu 305 310 315 320 Arg Asn Wing Gly Phe Asp Val Val Glu Leu Gln Gly Ser Tyr Asp Asn 325 330 335 Trp Val Arg His Asn 340 < 210 > 127 < 211 > 756 < 212 > DNA < 213 > Corynebacterium gl .utamicum < 220 > < 221 > CDS < 222 > (101) .. (733) < 223 > RXA00801 < 400 > 127 ggataagttt gtttctgagc gtattggtet tgatgatgtt gaagaggctt tcaacaccat 60 gaaggctggc gacgtgctgc gttctgtggt ggagatctaa atg gct falls gac gga 115 Met Ala His Asp Gly 1 5 ttg cgc gta gaa aac att gtc acc ggc tea ate ttt gcc ctt gat ggt 163 Leu Arg Val Glu Asn He Val Thr Ser Gly He Phe Ala Leu Asp Gly 10 15 20 ggc gaa tgg gaa gtc gac aac aac ate tgg gtt gtg gga aat gat gat 211 Gly Glu Trp Glu Val Asp Asn Asn He Trp Val Val Gly Asn Asp Asp 25 30 35 gag gtt ttc ate ate gat gcg gca cae act gca gca ccc ate ate gag 259 Glu Val Phe He He Asp Wing Wing His Thr Wing Wing Pro He He Glu 40 45 50 gct gtc ggt gg cgt gct gg aag ggc att ttg tgc acc falls gca falls 307 Wing Val Gly Gly Arg Wing Val Lys Gly He Leu Cys Thr His Wing His 55 60 65 aat gac cae ate act gtc gca cca gag cta tcc aag gaa ttt gat gca 355 Asn Asp His He Thr Val Wing Pro Glu Leu Ser Lys Glu Phe Asp Wing 70 75 80 85 cca ate ttc gtg falls cca ggt gac caa atg ctg tgg gag gaa acc falls 403 Pro He Phe Val His Pro Gly Asp Gln Met Leu Trp Glu Glu Thr His 90 95 100 gga aac ctg acc fall gag gat ttg gca gat cag cag aag ttc ca ate 451 Gly Asn Leu Thr His Glu Asp Leu Wing Asp Gln Gln Lys Phe Gln He 105 110 115 gct gga act gaa ctg ate gtg ctt aat acc ect gga cae tea ect gga 499 Wing Gly Thr Glu Leu He Val Leu Asn Thr Pro Gly His Ser Pro Gly 120 125 130 tcc age tgc ttc tac etc ect gaa gca aac gag etc ttc tet gga gac 547 Ser Ser Cys Phe Tyr Leu Pro Glu Wing Asn Glu Leu Phe Ser Gly Asp • 135 140 145 act ttc cag ggt ggg ccg gga gca act ggc cgt aag tac age tcc 595 Thr Leu Phe Gln Gly Gly Pro Gly Wing Thr Gly Arg Lys Tyr Ser Ser 150 155 160 165 ttt gac acc ate att gag tcc etc aag acc tea att ttg gat cta cca 643 Phe Asp Thr He He Glu Ser Leu Lys Thr Ser He Leu Asp Leu Pro 170 175 180 gcg gaa acc acc gtg cgc act ggc cat ggt gat falls acc agt gtg ggg 691 wing Glu Thr Thr Val Arg Thr Gly His Gly Asp His Thr Ser Val Gly 185 190 195 gct gag gct cca falls ttg gag gaa tgg att aa a cgc ggg drops 733 Ala Glu Ala Pro His Leu Glu Glu Trp He Lys Arg Gly His 10 200 205 210 taagccccga acgattagta ggc 756 • < 210 > 128 < 211 > 211 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 128 Met Ala His Asp Gly Leu Arg Val Glu Asn He Val Thr Ser Gly He 1 5 10 15 Phe Ala Leu Asp Gly Glu Glu Trp Glu Val Asp Asn Asn He Trp Val 15 20 25 30 Val Gly Asn Asp Asp Glu Val Phe He He Asp Ala Ala His Thr Ala 35 40 45 Ala Pro He He Glu Ala Val Gly Gly Arg Ala Val Lys Gly He Leu 50 55 60 Cys Thr His Ala His Asn Asp His He Thr Val Ala Pro Glu Leu Ser 65 70 75 80 Lys Glu Phe Asp Ala Pro He Phe Val His Pro Gly Asp Gln Met Leu F 85 90 95 Trp Glu Glu Thr His Gly Asn Leu Thr His Glu Asp Leu Wing Asp Gln 100 105 110 Gln Lys Phe Gln He Wing Gly Thr Glu Leu He Val Leu Asn Thr Pro 20 115 120 125 Gly His Ser Pro Gly Ser Ser Cys Phe Tyr Leu Pro Glu Wing Asn Glu 130 135 140 Leu Phe Ser Gly Asp Thr Leu Phe Gln Gly Gly Pro Gly Wing Thr Gly 145 150 155 160 Arg Lys Tyr Being Ser Phe Asp Thr He He Glu Being Leu Lys Thr Ser 165 170 175 He Leu Asp Leu Pro Wing Glu Thr Thr Val Arg Thr Gly His Gly Asp 180 185 190 His Thr Ser Val Gly Wing Glu Wing Pro His Leu Glu Glu Trp He Lys 195 200 205 Arg Gly His 25 210 <; 210 > 129 < 211 > 966 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (943) < 223 > RXA00821 < 400 > 129 ttaaaagctt gcttctcgac gcaaaaaccc atccggcgca tcccttcaat gttaggggtg 60 cgctgctatt tttctcccca gttctacgaa atgacttatt gtg act aag ctt gag 115 Val Thr Lys Leu Glu 1 5 cgc atg gag cat ect gct tac age caa ttg cgg ccg gtt acc ccg tcc 163 Arg Met Glu His Pro Ala Tyr Ser Gln Leu Arg Pro Val Thr Pro Ser 10 15 20 gca tet gtt gtt ttg tgc ect aat ccc ggt tac age tcg ctg gaa ggc 211 10 Ala Ser Val Val Leu Cys Pro Asn Pro Gly Tyr Ser Ser Leu Glu Gly 25 30 35 act aat tet tgg gtt ate cgg gca cca gaa gac ccc cgg age att gtc 259 Thr Asn Ser Trp Val He Arg Wing Pro Glu Asp Pro Arg Ser He Val • 40 45 50 ate gat cca ggt ect gaa gat gag ggc falls ctt aac gtc ttg cat tcc 307 He Asp Pro Gly Pro Glu Asp Glu Gly His Leu Asn Val Leu His Ser 55 60 65 aag gct gag gag gtg ggt ttg att ctt ctg acc fall cgt fall tat gat 355 Lys Wing Glu Glu Val Gly Leu He Leu Leu Thr His Arg His Tyr Asp 70 75 80 85 cat gct gac ggc gca cag cgt ttc cgt cag ctg acc aat gca ect gtg 403 15 His Wing Asp Gly Wing Gln Arg Phe Arg Gln Leu Thr Asn Wing Pro Val 90 95 100 cgt gcg atg gac ect tcg tac tgt ggt gcg gag gag att cat gat 451 Arg Wing Met Asp Pro Ser Tyr Cys Wing Gly Wing Glu Glu He His Asp 105 110 115 ggt gag ate ate acg ate gac ggt gtc acc cca cag att gag gtg gtg 499 Gly Glu He He Thr He Asp Gly Val Thr Pro Gln He Glu Val Val 120 125 130 gcc here ect ggt cat acc cgt gat tet gtg tet tat ttc ate tgg agt 547 • Wing Thr Pro Gly His Thr Arg Asp Ser Val Ser Tyr Phe He Trp Ser 135 140 145 gga gtc ect cat gag tcc act ttg gag ggc ate gtt tet ggc gac acc 595 20 Gly Val Pro His Glu Ser Thr Leu Glu Gly He Val Ser Gly Asp Thr 150 155 160 165 att gcg ggt cgt falls acc acg atg att tea gag acc gac ggc gat ttg 643 He Wing Gly Arg His Thr Thr Met He Ser Glu Thr Asp Cly Asp Leu 170 175 180 ggt gag tac ctg aat tet ttg gcc att ttg gag gag cgc ggc aag gat 691 Gly Glu Tyr Leu Asn Ser Leu Wing He Leu Glu Glu Arg Gly Lys Asp 185 190 195 att ccg ctg ctt cca gga cat ggt cca gat gga cag gac gtg tcc tcc 739 He Pro Leu Leu Pro Gly His Gly Pro Asp Gly Gln Asp Val Ser Ser 200 205 210 ttc gcg cgt aag tac att gag cgt cgt gag ctg cgt ctg aac cag ate 787 25 Phe Ala Arg Lys Tyr He Glu Arg Arg Glu Leu Arg Leu Asn Gln He -sM • xk, 215 220 - 225 cgt gag gta tgg gag acc cgt ggc cgt gac gtg tcc atg aag gat etc 835 Arg Glu Val Trp Glu Thr Arg Gly Arg Asp Val Ser Met Lys Asp Leu 230 235 240 245 ate gac gcc ate tac gat gat gtt gat cca gtt ctg cgt ggt gca gcc 883 He Asp Wing He Tyr Asp Asp Val Asp Pro Val Leu Arg Gly Ala Wing 255 255 260 gag cag tcc act cat gtg gct att cgt tac ctg cag gct cag gaa gct 931 • Glu Gln Ser Thr His Val Wing He Arg Tyr Leu Gln Wing Gln Glu Wing 265 270 275 tcc gcc tea aac taaacacttt taactaaaca here 966 Ser Ala Ser Asn 280 < 210 > 130 < 211 > 281 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 130 10 Val Thr Lys Leu Glu Arg Met Glu His Pro Wing Tyr Ser Gln Leu Arg 1 5 10 15 Pro Val Thr Pro Ser Wing Val Val Leu Cys Pro Asn Pro Gly Tyr • 20 25 30 Ser Ser Leu Glu Gly Thr Asn Ser Trp Val He Arg Wing Pro Glu Asp 35 40 45 Pro Arg Ser He Val He Asp Pro Gly Pro Glu Asp Glu Gly His Leu 50 55 60 Asn Val Leu His Ser Lys Wing Glu Glu Val Gly Leu He Leu Leu Thr 65 70 75 80 His Arg His Tyr Asp His Wing Asp Gly Wing Gln Arg Phe Arg Gln Leu 85 90 95 15 Thr Asn Wing Pro Val Arg Wing Met Asp Pro Ser Tyr Cys Wing Gly Wing 100 105 110 Glu Glu He His Asp Gly Glu He He Thr He Asp Gly Val Thr Pro 115 120 125 Gln He Glu Val Val Wing Thr Pro Gly His Thr Arg Asp Ser Val Ser 130 135 140 Tyr Phe He Trp Ser Gly Val Pro His Glu Ser Thr Leu Glu Gly He 145 150 155 160 # Val Ser Gly Asp Thr He Wing Gly Arg His Thr Thr Met He Ser Glu 165 170 175 Thr Asp Gly Asp Leu Gly Glu Tyr Leu Asn Ser Leu Wing He Leu Glu 180 185 190 20 Glu Arg Gly Lys Asp He Pro Leu Leu Pro Gly His Gly Pro Asp Gly 195 200 205 Gln Asp Val Ser Ser Phe Wing Arg Lys Tyr He Glu Arg Arg Glu Leu 210 215 220 Arg Leu Asn Gln He Arg Glu Val Trp Glu Thr Arg Gly Arg Asp Val 225 230 235 240 Ser Met Lys Asp Leu He Asp Ala He Tyr Asp Asp Val Asp Pro Val 245 250 255 Leu Arg Gly Wing Wing Glu Gln Ser Thr His Val Wing He Arg Tyr Leu 260 265 270 Gln Wing Gln Glu Wing Being Wing Ser Asn 275 280 25 < 210 > 131 < 211 > 1530 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1507) < 223 > RXN02966 < 400 > 131 aaatataccc < eccatgggt¡at cttgacagat taaagetega tgttttatggc 1tetacatata 60 cccccacggg 1tatccccti: a actttgatct aa < ggtgtcac atg ctt ttt gaa cgc 115 Met Leu Phe Glu Arg 1 5 ate tac gaa gag ggc etc gcc ca gcc age tat ttc att ggc tgc caa 163 He Tyr Glu Glu Gly Leu Ala Gln Ala Ser Tyr Phe He Gly Cys Gln 10 15 20 cgc gaa ggc aaa gcg att gtt gtt gat gct cgc cga gat ate cag acc 211 Arg Glu Gly Lys Ala He Val Val Asp Ala Arg Arg Asp He Gln Thr 10 25 30 35 tat ctg gac ctt gca gca aaa aac aac atg gtc att age gcc gta acc 259 Tyr Leu Asp Leu Wing Wing Lys Asn Asn Met Val Val Ser Ser Wing Val Thr 40 45 50 • gaa acc cat cat cat gcc gat tat etc tcc ggt act cgc gaa ctt gca 307 Glu Thr His He His Wing Asp Tyr Leu Be Gly Thr Arg Glu Leu Wing 55 60 65 gct gcc acc ggc gcc gag att ttc etc tet ggc gaa ggc gga gct gat 355 Wing Wing Thr Gly Wing Glu He Phe Leu Ser Gly Glu Gly Gly Wing Asp 70 75 80 85 tgg ca tat ggc ttt here ggc acc acc ttg atg falls aat tcc acc ate 403 Trp Gln Tyr Gly Phe Thr Gly Thr Thr Leu Met His Asn Ser Thr He 15 90 95 100 aag ctg gga aat ate acc ate gcc aag falls act ccc gga cae act 451 Lys Leu Gly Asn He Thr He Thr Ala Lys His Thr Pro Gly His Thr 105 110 115 cca gag falls ctg tea ttt ttg att act gat ggt gcg gtc tea aag gat 499 Pro Glu His Leu Ser Phe Leu He Thr Asp Gly Ala Val Ser Lys Asp 120 125 130 ccc ggt ttt atg etc age ggt gac ttc gtc ttc gta ggt gac gtg gga 547 Pro Gly Phe Met Leu Ser Gly Asp Phe Val Phe Val Gly Asp Val Gly • 135 140 145 cgt cca gat tta ctt gat gag gca gct ggc ggc gtg gac acc cgc ttc 595 Arg Pro Asp Leu Asu Glu Ala Ala Gly Gly Val Asp Thr Arg Phe 20 150 155 160 165 gcc gga gca cag caca etc ttc cat age cta aaa gag cag ttc ctt gca 643 Wing Gly Wing Gln Gln Leu Phe His Ser Leu Lys Glu Gln Phe Leu Wing 170 175 l? O etc ccc gac falls att cag gtt tat cca ggt cat ggt gct ggc age ect 691 Leu Pro Asp His He Gln Val Tyr Pro Gly His Gly Wing Gly Ser Pro 185 190 195 tgt ggc aag gca ttg ggc gcg ate ect age acc acc gtg gga Tat Gaa 739 Cys Gly Lys Ala Leu Gly Ala He Pro Ser Thr Thr Val Gly Tyr Glu 200 205 210 aag gct aat gcg tgg tgg gct cca tat ctg cgc agt gat gat gaa gcc 787 Lys Wing Asn Wing Trp Trp Wing Pro Tyr Leu Arg Be Asp Asp Glu Ala 25 215 220 225 líí .L, ¡i M.,. 4 ggc ttt gtg gaa gag ctt etc gac ggc cag cca gat gcc drops gct tac 835 gly phe val glu glu leu leu asp gly gln pro asp ala his ala tyr 230 235 240 245 ttt gct cgc atg aaa aag cag aac aag cag gga ect gca gta ctt agt 883 Phe Wing Arg Met Lys Lys Gln Asn Lys Gln Gly Pro Wing Val Leu Ser 250 255 260 here tta tcc ccg ctt gtg aag cta gaa gcc gag gaa gtc gtc gaa aag 931 Thr Leu Ser Pro Leu Val Lys Leu Glu Wing Glu Glu Val Val Glu Lys • 265 270 275 ctt ggt tet gaa gca gta ttt gtg gat acc cgc gag caa aac ca gtc 979 Leu Gly Ser Glu Wing Val Phe Val Asp Thr Arg Glu Gln Asn Gln Val 280 285 290 cat etc gga acc gtt gtt ggg ggg gt gt ttg aat att ccg cgc ggc gcc aag 1027 His Leu Gly Thr Val Val Gly Ala Leu Asn He Pro Arg Gly Ala Lys 295 300 305 gcg tcc aat ttt gcg gcg tgg gtt att gat ect ca g aag gat gct cag 1075 Wing Being Asn Phe Wing Wing Trp Val He Asp Pro Gln Lys Asp Wing Gln 310 315 320 325 gac ctt att gtt ttg gct ccg gac gcc aat acc gct gcg gat ttc cgc 1123 Asp Leu He Val Leu Wing Pro Asp Wing Asn Thr Wing Wing Asp Phe Arg 10 330 335 340 gac gct ttg ctg cgg gtt ggc ate gac act gtg tat tat ttc acc aac 1171 Asp Ala Leu Leu Arg Val Gly He Asp Thr Val Arg Tyr Phe Thr Asn • 345 350 355 agt ate gat gga ttg ect acc ttt gtg cca gaa etc ate tcc cct gct 1219 Ser He Asp Gly Leu Pro Thr Phe Val Pro Glu Leu He Ser Pro Wing 360 365 370 gag cta gct gag acc aac tat gac gca ctg att gat ate cgt gca aag 1267 Glu Leu Wing Glu Thr Asn Tyr Asp Wing Leu He Asp He Arg Wing Lys 375 380 385 tcc gaa ttt gcc gct ggc age att ccc ggc gcg cag cag ctt tet gga 1315 Ser Glu Phe Wing Wing Gly Ser He Pro Gly Wing Gln Gln Leu Ser Gly 15 390 395 400 405 ggt tcg gcc atg tgg cgc etc aat gag ctg ect gcg ggt ggc act ttg 1363 Gly Ser Wing Met Trp Arg Leu Asn Glu Leu Pro Wing Gly Gly Thr Leu 410 415 420 gta acc ttc tgc ca g tea gga gcg cga aat acc gtg gta gcc aat gct 1476 Val Thr Phe Cys Gln Ser Gly Wing Arg Asn Thr Val Val Wing Asn Wing 425 430 435 ttg cga cgc gcc gga ttc acc gtt ate gag etc gag ggc age tac gcc 1459 Leu Arg Arg Wing Gly Phe Thr Val He Glu Leu Glu Gly Ser Tyr Wing 440 445 450 gcg tgg gaa aaa tea gct gcc aat ect aaa aac ttg cag act gcc gtc 1507 Ala Trp Glu Lys Ser Ala Ala Asn Pro Lys Asn Leu Gln Thr Ala Val 20 455 460 465 tagt -.tttaga t -.ccggcgctg tat 1530 < 210 > 132 < 211 > 469 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 132 Met Leu Phe Glu Arg He Tyr Glu Glu Gly Leu Wing Gln Wing Being Tyr 1 5 10 15 Phe He Gly Cys Gln Arg Glu Gly Lys Wing He Val Val Asp Wing Arg 25 20 25 30 Arg Asp He Gln Thr Tyr Leu Asp Leu Ala Ala Lys Asn Asn Met Val 35 40 45 Be Ser Wing Val Thr Glu Thr His He His Wing Asp Tyr Leu Ser Gly 50 55 60 Thr Arg Glu Leu Ala Ala Wing Thr Gly Wing Glu He Phe Leu Ser Gly 65 70 75 80 Glu Gly Gly Wing Asp Trp Gln Tyr Gly Phe Thr Gly Thr Thr Leu Met 85 90 95 His Asn Ser Thr He Lys Leu Gly Asn He Thr He Thr Wing Lys His 100 105 110 Thr Pro Gly His Thr Pro Glu His Leu Ser Phe Leu He Thr Asp Gly 115 120 125 Wing Val Ser Lys Asp Pro Gly Phe Met Leu Ser Gly Asp Phe Val Phe 130 135 140 Val Gly Asp Val Gly Arg Pro Asp Leu Leu Asp Glu Wing Wing Gly Gly 145 150 155 160 Val Asp Thr Arg Phe Ala Gly Ala Gln Gln Leu Phe His Ser Leu Lys 165 170 175 Glu Gln Phe Leu Ala Leu Pro Asp His He Gln Val Tyr Pro Gly His 180 185 190 10 Gly Ala Gly Ser Pro Cys Gly Lys Ala Leu Gly Ala He Pro Ser Thr 195 200 205 Thr Val Gly Tyr Glu Lys Wing Asn Wing Trp Trp Wing Pro Tyr Leu Arg 210 215 220 Ser Asp Asp Glu Wing Gly Phe Val Glu Glu Leu Leu Asp Gly Gln Pro 225 230 235 240 Asp Wing His Wing Tyr Phe Wing Arg Met Lys Lys Gln Asn Lys Gln Gly 245 250 255 Pro Wing Val Leu Ser Thr Leu Ser Pro Leu Val Lys Leu Glu Wing Glu 260 265 270 Glu Val Val Glu Lys Leu Gly Ser Glu Wing Val Phe Val Asp Thr Arg 275 280 285 15 Glu Gln Asn Gln Val His Leu Gly Thr Val Val Gly Ala Leu Asn He 290 295 300 Pro Arg Gly Ala Lys Ala Ser Asn Phe Ala Ala Trp Val He Asp Pro 305 310 315 320 Gln Lys Asp Ala Gln Asp Leu He Val Leu Ala Pro Asp Ala Asn Thr 325 330 335 Wing Wing Asp Phe Arg Asp Wing Leu Leu Arg Val Gly He Asp Thr Val 340 345 350 Arg Tyr Phe Thr Asn Ser He Asp Gly Leu Pro Thr Phe Val Pro Glu • 355 360 365 Leu He Ser Pro Ala Ala Glu Leu Ala Glu Thr Asn Tyr Asp Ala Leu He 370 375 380 20 Asp He Arg Ala Lys Ser Glu Phe Ala Ala Gly Ser He Pro Gly Ala 385 390 395 400 Gln Gln Leu Ser Gly Gly Be Wing Met Trp Arg Leu Asn Glu Leu Pro 405 410 415 Wing Gly Gly Thr Leu Val Thr Phe Cys Gln Ser Gly Wing Arg Asn Thr 420 425 430 Val Val Wing Asn Wing Leu Arg Arg Wing Gly Phe Thr Val He Glu Leu 435 440 445 Glu Gly Ser Tyr Wing Wing Trp Glu Lys Ser Wing Wing Asn Pro Lys Asn 450 455 460 Leu Gln Thr Wing Val 465 25 < 210 > 133 < 211 > 1530 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1507) < 223 > FRXA01833 < 400 > 133 aaatataccc icccaigggtat cttgat -agat taaagetega tgttttaiggc 1tetacatata 60 cccccacggg -tatcccctca acttttgatct aatggtgtcac atg ctt ttt gaa cgc 115 Met Leu Phe Glu Arg 1 5 ate tac gaa gaa ggc etc gcc ca gcc age tat ttc att ggc tgc caa 163 He Tyr Glu Glu Gly Leu Wing Gln Wing Being Tyr Phe He Gly Cys Gln 10 15 20 cgc gaa ggc aaa gcg att gtt gtt gat gct cgc cga gat ate cag acc 211 Arg Glu Gly Lys Ala He Val Val Asp Ala Arg Arg Asp He Gln Thr 25 30 35 tat ctg gac ctt gca gca aaa aac aac atg gtc att age gcc gta acc 259 Tyr Leu Asp Leu Wing Wing Lys Asn Asn Met Val Wing Ser Wing Val Thr 40 45 50 gaa acc cat ca cat gcc gat tat etc tcc ggt act cgc gaa ctt gca 307 Glu Thr His He His Wing Asp Tyr Leu Ser Gly Thr Arg Glu Leu Wing 55 60 65 gct gcc acc ggc gcc gag att ttc etc tet ggc gaa ggc gga gct gat 355 Ala Ala Thr Gly Ala Glu He Phe Leu Ser Gly Glu Gly Gly Ala Asp 70 75 80 85 tgg ca g tat ggc ttt here ggc acc acc ttg atg cae aat tcc acc ate 403 Trp Gln Tyr Gly Phe Thr Gly Thr Thr Leu Met His Asn Ser Thr He 90 95 100 aag ctg gaa aat ate acc ate here gcc aag cae act ccc gga cae act 451 Lys Leu Glu Asn He Thr He Thr Wing Lys His Thr Pro Gly His Thr 105 110 115 cca gag falls ctg tea ttt ttg att act gat ggt gcg gtc tea aag gat 499 Pro Glu His Leu Ser Phe Leu He Thr Asp Gly Wing Val Ser Lys Asp 120 125 130 ccc ggt ttt atg etc age ggt gac ttc gtc ttc gta ggt gac gtg gga 547 Pro Gly Phe Met Leu Ser Gly Asp Phe Val Phe Val Gly Asp Val Gly 135 140 145 cgt cca gat tta ctt gat gag gca gct ggc ggc gtg gac acc cgc ttc 595 Arg Pro Asp Leu Leu Asp Glu Wing Wing Gly Gly Val Asp Thr Arg Phe 150 155 160 165 gcc gga gca cag caa etc ttc cat age cta aaa gag cag ttc ctt gca 643 Ala Gly Ala Gln Gln Leu Phe His Ser Leu Lys Glu Gln Phe Leu Wing 170 175 180 etc ccc gac falls att cag gtt tat cca ggt cat ggt gct ggc age ect 691 Leu Pro Asp His He Gln Val Tyr Pro Gly His Gly Wing Gly Ser Pro 185 190 195 tgt ggc aag gca ttg ggc gcg ate ect age acc acc gtg gga tat gaa 739 Cys Gly Lys Ala Leu Gly Ala He Pro Ser Thr Thr Val Gly Tyr Glu 200 205 210 aag gct aat gcg tgg tgg gct cca tat ctg cgc agt gat gat gaa gcc 787 Lys Wing Asn Wing Trp Trp Wing Pro Tyr Leu Arg Ser Asp Asp Glu Wing 215 220 225 ggc ttt gtg gag gag ctt etc gac ggc cag cca gat gcc drops gct tac 835 Gly Phe Val Glu Glu Leu Leu Asp Gly Gln Pro Asp Ala His Wing Tyr 230 235 240 245 ttt gct cgc atg aaa aag aa g aag agate ca g g a gca gta ctt agt 883 Phe Wing Arg Met Lys Lys Gln Asn Lys Gln Gly Pro Wing Val Leu Ser 250 255 260 here tta tcc ccg ctt gtg aag cta gaa gcc gag gaa gtc gtc gaa aag 931 Thr Leu Ser Pro Leu Val Lys Leu Glu Wing Glu Glu Val Val Glu Lys 265 270 275 • ctt ggt tet gaa gca gta ttt gtg gat acc cgc gag caa aac ca gtc 979 Leu Gly Ser Glu Wing Val Phe Val Asp Thr Arg Glu Gln Asn Gln Val 280 285 290 cat etc gga acc gtt gtt ggg gca ttg aat att ccg cgc ggc gcc aag 1027 His Leu Gly Thr Val Val Gly Ala Leu Asn He Pro Arg Gly Ala Lys 295 300 305 gcg tcc aat ttt gcg gcg tgg gtt att gat ect cag aag gat gct cag 1075 Wing Being Asn Phe Wing Wing Trp Val He Asp Pro Gln Lys Asp Wing Gln 310 315 320 325 gac ctt att gtt ttg gct c cg gac gcc aat acc gct gcg gat tcc cgc 1123 Asp Leu He Val Leu Wing Pro Asp Wing Asn Thr Wing Wing Asp Phe Arg 10 330 335 340 gac gct ttg ctg cgg gtt ggc ate gac act gtg cgt tat ttc acc aac 1171 Asp Ala Leu Leu Arg Val Gly He Asp Thr Val Arg Tyr Phe Thr Asn 345 350 355 • agt ate gat gga ttg ect acc ttt gtg cca gaa etc tcc ccc cct gct 1219 Ser He Asp Gly Leu Pro Thr Phe Val Pro Glu Leu He Ser Pro Wing 360 365 370 gag cta gct gag acc aac tat gac gca ctg att gat ate cgt gca gt aag 1267 Glu Leu Ala Glu Thr Asn Tyr Asp Ala Leu He Asp He Arg Ala Lys 375 380 385 cc gaa ttt gcc gct ggc age att ccc ggc gcg cag cag ctt tet gga 1315 Ser Glu Phe Wing Wing Gly Ser He Pro Gly Wing Gln Gln Leu Ser Gly 15 390 395 400 405 ggt tcg gcc atg tgg cgc etc aat gag ctg ect gcg ggt ggc act ttg 1363 Gly Be Wing Met Trp Arg Leu Asn Glu Leu Pro Wing Gly Gly Thr Leu 410 415 420 gta acc ttc tgc ca g tea gga gcg cga aat acc gtg gta gcc aat gct 1411 Val Thr Phe Cys Gln Ser Gly Ala Arg Asn Thr Val Val Wing Asn Wing 425 430 435 ttg cga cgc gcc gt gt ttc acc gtt ate gag etc gag ggc age tac gcc 1459 Leu Arg Arg Wing Gly Phe Thr Val He Glu Leu Glu Gly Ser Tyr Wing 440 445 450 gc g tgg gaa aaa tea gct gcc aat ect aaa aac ttg cag act gcc gtc 1507 Wing Trp Glu Lys Ser Wing Wing Asn Pro Lys Asn Leu Gln Thr Wing Val 20 455 460 465 tagttttaga tccggcgctg tat 1530 < 210 > 134 < 211 > 469 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 134 Met Leu Phe Glu Arg He Tyr Glu Glu Gly Leu Wing Gln Wing Being Tyr 1 5 10 15 Phe He Gly Cys Gln Arg Glu Gly Lys Wing He Val Val Asp Wing Arg 25 20 25 30 ? k ??? ld Arg Asp He Gln Thr Tyr Leu Asp Leu Wing Wing Lys Asn Asn Met Val 35 40 45 He Ser Wing Val Thr Glu Thr His He His Wing Asp Tyr Leu Ser Gly 50 55 60 Thr Arg Glu Leu Wing Wing Ala Thr Gly Wing Glu He Phe Leu Ser Gly 65 70 75 80 Glu Gly Gly Wing Asp Trp Gln Tyr Gly Phe Thr Gly Thr Thr Leu Met 85 90 95 • His Asn Ser Thr He Lys Leu Glu Asn He Thr He Thr Ala Lys His 100 105 110 Thr Pro Gly His Thr Pro Glu His Leu Ser Phe Leu He Thr Asp Gly 115 120 125 Wing Val Ser Lys Asp Pro Gly Phe Met Leu Ser Gly Asp Phe Val Phe 130 135 140 Val Gly Asp Val Gly Arg Pro Asp Leu Leu Asp Glu Wing Wing Gly Gly 145 150 155 160 Val Asp Thr Arg Phe Ala Gly Ala Gln Gln Leu Phe His Ser Leu Lys 165 170 175 Glu Gln Phe Leu Ala Leu Pro Asp His He Gln Val Tyr Pro Gly His 180 185 190 10 Gly Wing Gly Ser Pro Cys Gly Lys Wing Leu Gly Wing Pro Pro Thr 195 200 205 Thr Val Gly Tyr Glu Lys Wing Asn Wing Trp Trp Wing Pro Tyr Leu Arg • 210 215 220 Ser Asp Asp Glu Wing Gly Phe Val Glu Glu Leu Leu Asp Gly Gln Pro 225 230 235 240 Asp Wing His Wing Tyr Phe Wing Arg Met Lys Lys Gln Asn Lys Gln Gly 245 250 255 Pro Wing Val Leu Ser Thr Leu Ser Pro Leu Val Lys Leu Glu Wing Glu 260 265 270 Glu Val Val Glu Lys Leu Gly Ser Glu Ala Val Phe Val Asp Thr Arg 275 280 285 15 Glu Gln Asn Gln Val His Leu Gly Thr Val Val Gly Ala Leu Asn He 290 295 300 Pro Arg Gly Ala Lys Ala Ser Asn Phe Ala Ala Trp Val He Asp Pro 305 310 315 320 Gln Lys Asp Wing Gln Asp Leu He Val Leu Wing Pro Asp Wing Asn Thr 325 330 335 Wing Wing Asp Phe Arg Asp Wing Leu Leu Arg Val Gly He Asp Thr Val 340 345 350 Arg Tyr Phe Thr Asn Ser He Asp Gly Leu Pro Thr Phe Val Pro Glu 355 360 365 Leu He Ser Pro Wing Glu Leu Wing Glu Thr Asn Tyr Asp Wing Leu He 370 375 380 20 Asp He Arg Wing Lys Ser Glu Phe Wing Wing Gly Ser He Pro Gly Wing 385 390 395 400 Gln Gln Leu Ser Gly Gly Be Wing Met Trp Arg Leu Asn Glu Leu Pro 405 410 415 Wing Gly Gly Thr Leu Val Thr Phe Cys Gln Ser Gly Wing Arg Asn Thr 420 425 430 Val Val Wing Asn Wing Leu Arg Arg Wing G and Phe Thr Val He Glu Leu 435 440 445 Glu Gly Ser Tyr Wing Wing Trp Glu Lys Ser Wing Wing Asn Pro Lys Asn 450 455 460 Leu Gln Thr Wing Val 465 25 T * '"i A. * Í-? J? .. - M» _ .. "__., ._. ._. __. ^".,. _, - -? T? FliMfc¡gra_B¡ < 210 > 135 < 211 > 675 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (652) < 223 > RXA01853 • gaatgtccaa icgtcaaaaaa a'ttcttttct atcctaaccg tatetteaca < eetttgaggga 60 atgatggggg agcgccgctt aicgcactaca ctgtttattc atg gag ate etc gga 115 Met Glu He Leu Gly 1 5 ttc gcg gct ggt ccg tat aaa here aat tgc tat gtg gtg cgc ggg gag 163 Phe Wing Wing Gly Pro Tyr Lys Thr Asn Cys Tyr Val Val Arg Gly Glu 10 15 20 aat gag gtc gcg ate att gat ect ggc atg cat gcc fall gat gat ttg 211 Asn Glu Val Wing He He Asp Pro Gly Met His Wing His Asp Asp Leu 10 25 30 35 ggttgg ggaaaa ttaacc ate acc acat aat aat ttg age gtg gac aag att gtg etc. 259 V Vaall GGlluu T Tyyrr He Thr Thr Asn Asn Leu Ser Val Asp Lys He Val Leu 4400 45 50 aacccc ccaaee ggggaa cae att gat falls acc cgt gat gct ggt gtt gtg gca aag 307 Thr His Gly His He Asp His Thr Arg Asp Ala Gly Val Val Ala Lys 55 60 65 cgt ttc aat gcg ccg gtc tat ate cat ect gat gat gcg ttt ttc ctt 355 Arg Phe Asn Ala Pro Val Tyr He His Pro Asp Asp Wing Phe Phe Leu 70 75 80 85 gag gtc tac aag gga tet gga here aag acg gcc atg ctt tcc gac gcc 403 Glu Val Tyr Lys Gly Ser Gly Thr Lys Thr Wing Met Leu Phe Asp Wing 15 90 95 100 gac aac atg gtg tcc ect gat ect gag tea ctg cgt gat ctg gtt gat 451 Asp Asn Met Val Ser Pro Asp Pro Glu Ser Leu Arg Asp Leu Val Asp 105 110 115 ggt gag here ate ttg gct ggc gaa gaa ttc acg ttg aag cat gca gca 499 Gly Glu Thr He Thr Leu Wing Gly Glu Glu Phe Thr Leu Lys His Wing 120 125 130 cca ggg cat tea ect ggt tgt acg ctg ate gtc ggc aag gaa tac tgc 547 Pro Gly His Ser Pro Gly Cys Thr Leu He Val Gly Lys Glu Tyr Cys 135 140 145 ttt age ggt gat gtg ttg ttc aag ggc tet att ggt cgc act gat ttt 595 Phe Ser Gly Asp Val Leu Phe Lys Gly Ser He Gly Arg Thr Asp Phe 20 150 155 160 165 gag tgg tet gat gca gat gcc atg aat gag tea cta cgc acg gca gtg 643 Glu Trp Ser Asp Wing Asp Wing Met Asn Glu Ser Leu Arg Thr Wing Val 170 175 180 etc cca ctt tgatgatgca ttgeagatt: c tt: c 675 Leu Pro Leu < 210 > 136 < 211 > 184 < 212 > PRT < 213 > Corynebacterium glutamicum 25 • ^ I ^ k .L- k.í < 400 > 136 Met Glu He Leu Gly Phe Wing Wing Gly Pro Tyr Lys Thr Asn Cys Tyr 1 5 10 15 Val Val Arg Gly Glu Asn Glu Val Wing He He Asp Pro Gly Met His 20 25 30 Wing His Asp Asp Leu Val Glu Tyr He Thr Thr Asn Asn Leu Ser Val 35 40 45 Asp Lys He Val Leu Thr His Gly His He Asp His Thr Arg Asp Wing 50 55 60 • Gly Val Val Wing Lys Arg Phe Asn Wing Pro Val Tyr He His Pro Asp 65 70 75 80 Asp Wing Phe Phe Leu Glu Val Tyr Lys Gly Ser Gly Thr Lys Thr Wing 85 90 95 Met Leu Phe Asp Wing Asp Asn Met Val Ser Pro Asp Pro Glu Ser Leu 100 105 110 Arg Asp Leu Val Asp Gly Glu Thr He Thr Leu Wing Gly Glu Glu Phe 115 120 125 Thr Leu Lys His Wing Pro Gly His Ser Pro Gly Cys Thr Leu He Val 130 135 140 Gly Lys Glu Tyr Cys Phe Ser Gly Asp Val Leu Phe Lys Gly Ser He 10 145 150 155 160 Gly Arg Thr Asp Phe Glu Trp Ser Asp Wing Asp Wing Met Asn Glu Ser 165 170 175 Leu Arg Thr Wing Val Leu Pro Leu • 180 < 210 > 137 < 211 > 723 < 212 > < 213 > Corynebacterium glutamicum < 220 > 15 < 221 > CDS < 222 > (101) .. (700) < 223 > RXN02424 < 400 > 137 agcc; aatgct < raactgccct tcaaaatcga tttttgtcgc ttcaaaaaat acaccttcga 60 acatagcatc < gaacaaggtg tttccgctag tctgaaccac atg act aac gag etc 115 Met Thr Asn Glu Leu 1 5 • act ctt falls cat att tcc gtg tcc caw atg gac aac aat tgc tac ctt 163 Thr Leu His His He Ser Val Ser Gln Met Asp Asn Asn Cys Tyr Leu 10 15 20 20 ttg gcc gca aat ggc aac ggt tta etc att gat gct gca gat gac gca 211 Leu Ala Wing Asn Gly Asn Gly Leu Leu He Asp Wing Wing Asp Asp Wing 25 30 35 gct gca cta ctt aaa tta gcc gaa gat gcc ggt gtg acc ate acc aaa 259 Ala Ala Leu Leu Lys Leu Ala Glu Asp Ala Gly Val Thr He Thr Lys 40 45 50 gtg ttg acc acc fall cgc falls gca gac falls gtc cgt gca ttg ccg gag 307 Val Leu Thr Thr His Arg His Wing Asp His Val Arg Ala Leu Pro Glu 55 60 65 gtt etc cag aag acc gga gca act falls tac gcg ect ttc ctt gag gtg 355 Val Leu Gln Lys Thr Gly Wing Thr His Tyr Wing Pro Phe Leu Glu Val 70 75 80 85 75 cca gct ttg ccc tcc gct gtt gat gtg gaa ctg cat cat ggt gat tea 403 Pro Ala Leu Pro Ser Wing Val Asp Val Glu Leu His His Gly Asp Ser 90 95 100 att gaa ttt gag ggt cat gta ttc ect ate age att ctg cgc ggc cae 451 He Glu Phe Glu Gly His Val Phe Pro He Be He Leu Arg Gly His 105 110 115 acc cca ggc ggc gca gta etc acc gct gag ate gac ggt aaa act drops 499 Thr Pro Gly Gly Wing Val Leu Thr Wing Glu He Asp Gly Lys Thr His 120 125 130 ctt ttc gtg ggt gac age etc ttc ccc ggc ggt ttg ggc aaa acc age 547 Leu Phe Val Gly Asp Ser Leu Phe Pro Gly Gly Leu Gly Lys Thr Ser 135 140 145 age gaa ggc gac ttc gtc cga ctg ttc aac gat gtc aaa gag cgc ate 595 Ser Glu Gly Asp Phe Val Arg Leu Phe Asn Asp Val Lys Glu Arg He 150 155 160 165 ttt gac acc tac gac gat gac age ate gtg tgg cca ggt falls ggc aag 643 Phe Asp Thr Tyr Asp Asp Asp Ser He Val Trp Pro Gly His Gly Lys 170 175 180 gaa acc acc ctt gga gcc gag cgt cca cag ctg gaa ate tgg tgg gag 691 Glu Thr Thr Leu Gly Ala Glu Arg Pro Gln Leu Glu He Trp Trp Glu 185 190 195 cgt cgc tgg taagcgcttt tctcaaccag gca 723 Arg Arg Trp 200 < 210 > 138 < 211 > 200 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 138 Met Thr Asn Glu Leu Thr Leu His His He Ser Val Val Gln Met Asp 1 5 10 15 Asn Asn Cys Tyr Leu Leu Wing Wing Asn Gly Asn Gly Leu Leu He Asp 20 25 30 Wing Wing Asp Wing Wing Wing Leu Leu Lys Leu Wing Glu Asp Wing Gly 35 40 45 Val Thr He Thr Lys Val Leu Thr Thr His Arg His Wing Asp His Val 50 55 60 Arg Wing Leu Pro Glu Val Leu Gln Lys Thr Gly Wing Thr His Tyr Wing 65 70 75 80 Pro Phe Leu Glu Val Pro Ala Leu Pro Ser Ala Val Asp Val Glu Leu 85 90 95 His His Gly Asp Ser He Glu Phe Glu Gly His Val Phe Pro He Ser 100 105 110 He Leu Arg Gly His Thr Pro Gly Gly Ala Val Leu Thr Ala Glu He 115 120 125 Asp Gly Lys Thr His Leu Phe Val Gly Asp Ser Leu Phe Pro Gly Gly 130 135 140 Leu Gly Lys Thr Ser Ser Glu Gly Asp Phe Val Arg Leu Phe Asn Asp 145 150 155 160 Val Lys Glu Arg He Phe Asp Thr Tyr Asp Asp Asp Asp Ser He Val Trp 165 170 175 Pro Gly His Gly Lys Glu Thr Thr Leu Gly Wing Glu Arg Pro Gln Leu 180 185 190 Glu He Trp Trp Glu Arg Arg Trp 195 200 < 210 > 139 < 211 > 404 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (381) < 223 > FRXA02424 • < 400 > 139 acc gga gca act drops tac gcg ect ttc ctt gag gtg cca gct tcg ccc 48 Thr Gly Ala Thr His Tyr Ala Pro Phe Leu Glu Val Pro Ala Leu Pro 1 5 10 15 tcc gct gtt gat gtg gaa ctg cat cat ggt gat tea att gaa ttt gag 96 Ser Ala Val Asp Val Glu Leu His His Gly Asp Ser He Glu Phe Glu 20 25 30 ggt cat gta ttc ect ate age att ctg cgc ggc falls acc cca ggc ggt 144 Gly His Val Phe Pro He Ser He Leu Arg Gly His Thr Pro Gly Gly 35 40 45 Q gca gta etc acc gct gag ate gac ggt aaa act falls ctt ttc gtg ggt 192 Wing Val Leu Thr Wing Glu He Asp Gly Lys Thr His Leu Phe Val Gly 50 55 60 gac age etc tcc ccc ggc ggt ttg ggc aaa acc age age gaa ggc gac 240 • Asp Ser Leu Phe Pro Gly Gly Leu Gly Lys Thr Ser Ser Glu Gly Asp 65 70 75 80 ttc gtc cga ctg ttc aac gat gtc aaa gag cgc ate ttt gac acc tac 288 Phe Val Arg Leu Phe Asn Asp Val Lys Glu Arg He Phe Asp Thr Tyr 85 90 95 gac gat gac age ate gtg tgg cca ggt falls ggc aag gaa acc acc ctt 336 Asp Asp Asp Ser He Val Trp Pro Gly His Gly Lys Glu Thr Thr Leu 100 105 110 gga gcc gg gag cgt cca cag ctg gaa ate tgg tgg gag cgt cgc tgg 381 Gly Wing Glu Arg Pro Gln Leu Glu He Trp Trp Glu Arg Arg Trp 115 120 125 taagcgcttt tctcaaccag gca 404 < 210 > 140 < 211 > 127 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 140 Thr Gly Ala Thr His Tyr Ala Pro Phe Leu Glu Val Pro Ala Leu Pro 20 1 5 10 15 Ser Ala Val Asp Val Glu Leu His His Gly Asp Ser He Glu Phe Glu 20 25 30 Gly His Val Phe Pro He Ser He Leu Arg Gly His Thr Pro Gly Gly 35 40 45 Wing Val Leu Thr Wing Glu He Asp Gly Lys Thr His Leu Phe Val Gly 50 55 60 Asp Ser Leu Phe Pro Gly Gly Leu Gly Lys Thr Ser Ser Glu Gly Asp 65 70 75 80 Phe Val Arg Leu Phe Asn Asp Val Lys Glu Arg He Phe Asp Thr Tyr 85 90 95 Asp Asp Asp Ser He Val Trp Pro Gly His Gly Lys Glu Thr Thr Leu 25 100 105 110 fitt Gly Wing Glu Arg Pro Gln Leu Glu He Trp Trp Glu Arg Arg Trp 115 120 125 < 210 > 141 < 211 > 882 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (859) < 223 > RXN00419 < 400 > 141 getggttgaa gactcgaaat gagategace caaceggagt ctttgcatct gacatgtccc 60 gccgacttga gctttcttaa gaaagggctt gaactaaaca atg ctt aac gca gtg 115 Met Leu Asn Ala Val 1 5 ggc aaa gcc caac aac att ctt ctt ct ggt gga acc tet gag ate ggt 163 Gly Lys Ala Gln Asn He Leu Leu Leu Gly Gly Thr Ser Glu He Gly 10 10 15 20 att tcc att gtc tcc cgc ttc etc aag cag ggt cca ccc cat gtg acc 211 He Ser He Val Ser Arg Phe Leu Lys Gln Gly Pro Ser His Val Thr • 25 30 35 ttg gca gcg cgt aaa gat ccc cgc gtg gac gca gca gc gca gg gag 259 Leu Wing Wing Arg Lys Asp Ser Pro Arg Val Asp Wing Wing Val Wing Glu 40 45 50 aaa gca gct gct gct gct gct gct gct gtt gtt gtt gat gat ttc gcg 307 He Lys Wing Wing Gly Wing Wing Val Val Asp Phe Asp Wing 55 60 65 etc gac acc gaa tcc falls ect gcc gcc ate gac gca gcc ttt gaa aac 355 Leu Asp Thr Glu Ser His Pro Ala Ala He Asp Ala Wing Phe Glu Asn 15 70 75 80 85 ggc gac gtt gac gta gt ate gtg gct tcc ggc ate gcc aac gcc 403 Gly Asp Val Asp Val Wing He Val Al to Phe Gly He Leu Gly Asp Asn 90 95 100 gaa gca cag tgg cgc gac ca gca cca gca gtg gaa gca acc acc gtg 451 Glu Wing Gln Trp Arg Asp Gln Ala Leu Wing Val Glu Wing Thr Thr Val 105 110 115 aac tac acc gcc ggc gtt tc gta gta gta gt gt gt gt gt ggt ctg ggc cag aaa ttt 499 • Asn Tyr Thr Ala Gly Val Ser Val Gly Val Leu Glu Gln Lys Phe 120 125 130 gag cag ggc cag ggc gtg gtc gtc gtg gtg 547 Glu Gln Gln Gly His Gly Thr He Val Wing Leu Ser Ser Val Wing Gly 20 135 140 145 cag cga gtc cgc cgc tcc aac ttt gtc tac ggc tcc gcc aag gca ggt 595 Gln Arg Val Arg Arg Ser Asn Phe Val Tyr Gly Ser Ala Lys Ala Gly 150 155 160 165 ttc gac ggt ttc tac acc cag etc ggc gaa gcc ctg cgt gga tcc ggt 643 Phe Asp Gly Phe Tyr Thr Gln Leu Gly Glu Wing Leu Arg Gly Ser Gly 170 175 180 gcc aac gta ttg gtg gtt cgc cca ggc cag gta cgc acc aag atg tcc 691 Wing Asn Val Leu Val Val Arg Pro Gly Gln Val Arg Thr Lys Met Ser 185 190 195 gca gat ggt ggc gaa gcc cca ctg acc gtc aac cgc gaa gac gtg gca 739 Wing Asp Gly Gly Glu Wing Pro Leu Thr Val Asn Arg Glu Asp Val Wing 25 200 205 210 u il? siíÉlltK? AND? L ??,?,? ^^ aií? & i4¿ »_» «___. , ._.._-, _ .__,. . . ......, ._, _. ^ .. ...,. . ^? - - * - * • ** > * * * - gat gct gtt tat gat gca gtg gtg aac aag aag gac ate ate ttt gtc 787 Asp Wing Val Tyr Asp Wing Val Val Asn Lys Asp He He Phe Val 215 220 225 cca ctg ctg ctg ctg gtc gtc tet ctg ttc cat ttc att ccg cga 835 His Pro Leu Phe Gln Tyr Val Ser Phe Wing Phe Gln Phe He Pro Arg 230 235 240 245 gca ate ttc cgc aag ctg ccg ttc taacggaagt tacggaagtt acg 882 Wing He Phe Arg Lys Leu Pro Phe 250 • < 210 > 142 < 211 > 253 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 142 Met Leu Asn Wing Val Gly Lys Wing Gln Asn He Leu Leu Leu Gly Gly 1 5 10 15 Thr Ser Glu He Gly He Ser Be He Val Ser Arg Phe Leu Lys Gln Gly 20 25 30 10 Pro Ser His Val Thr Leu Ala Ala Arg Lys Asp Ser Pro Arg Val Asp 35 40 45 Wing Wing Val Wing Glu He Lys Wing Wing Gly Wing Wing Val Wing Val 55 55 60 • Val Asp Phe Asp Wing Leu Asp Thr Glu Ser His Pro Wing Wing Asp 65 70 75 80 Ala Ala Phe Glu Asn Gly Asp Val Asp Val Ala He Val Ala Phe Gly 85 90 95 He Leu Gly Asp Asn Glu Ala Gln Trp Arg Asp Gln Ala Leu Ala Val 100 105 110 Glu Ala Thr Thr Val Asn Tyr Thr Ala Gly Val Ser Val Gly Val Leu 115 120 125 15 Leu Gly Gln Lys Phe Glu Gln Gln Gly His Gly Thr He Val Wing Leu 130 135 140 Ser Ser Val Wing Gly Gln Arg Val Arg Arg Ser Asn Phe Val Tyr Gly 145 150 155 160 Ser Ala Lys Ala Gly Phe Asp Gly Phe Tyr Thr Gln Leu Gly Glu Ala 165 170 175 Leu Arg Gly Ser Gly Ala Asn Val Leu Val Val Arg Pro Gly Gln Val 180 185 190 Arg Thr Lys Met Ser Ala Asp Gly Gly Glu Ala Pro Leu Thr Val Asn • 195 200 205 Arg Glu Asp Val Wing Asp Wing Val Tyr Asp Wing Val Val Asn Lys Lys 210 215 220 20 Asp He He Phe Val His Pro Leu Phe Gln Tyr Val Ser Phe Wing Phe 225 230 235 240 Gln Phe He Pro Arg Ala He Phe Arg Lys Leu Pro Phe 245 250 < 210 > 143 < 211 > 485 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS 25 < 222 > (1) • (462) < 223 > FRXA00419 < 400 > 143 gac aac gaa gca cag tgg cgc gac caca gca cta gca gtg gaa gca acc 48 Asp Asn Glu Wing Gln Trp Arg Asp Gln Wing Leu Wing Val Glu Wing Thr 1 5 10 15 acc gtg aac tac acc gcc ggc gtt tcc gta ggt gta ctg ctg ggc cag 96 Thr Val Asn Tyr Thr Wing Gly Val Ser Val Gly Val Leu Leu Gly Gln 20 25 30 • aaa ttt gag cag cag ggc falls ggc acc ate gtg gca ttg tcc tet gtg 144 Lys Phe Glu Gln Gln Gly His Gly Thr He Val Ala Leu Ser Ser Val 35 40 45 gca ggc cag cga gtc cgc cgc aka aac ttt gtc tac ggc aka gcc aag 192 Ala Gly Gln Arg Val Arg Arg Ser Asn Phe Val Tyr Gly Ser Ala Lys 50 55 60 gca ggt ttc gac ggt ttc tac acc ggc gac gcc ggt cgt gga 240 Wing Gly Phe Asp Gly Phe Tyr Thr Gln Leu Gly Glu Wing Leu Arg Gly 65 70 75 80 tcc ggt gcc aac gta ttg gtg gtt cgc cca ggc cag gta cgc acc aag 288 Ser Gly Ala Asn Val Leu Val Val Arg Pro Gly Gln Val Arg Thr Lys October 85 90 95 atg aka gca gat ggt ggc gaa gcc cca ctg acc gtc aac cgc gaa gac 336 Met Ser Ala Asp Gly Gly Glu Ala Pro Leu Thr Val Asn A rg Glu Asp 100 105 110 • gtg gca gat gct gtt tat gat gca gtg gtg aac aag aag gac ate ate 384 Val Ala Asp Ala Val Tyr Asp Ala Val Val Asn Lys Lys Asp He He 115 120 125 ttt gtc falls cca ctg ttc cag tac gtc tet ttt gcg ttc cat ttc att 432 Phe Val His Pro Leu Phe Gln Tyr Val Ser Phe Wing Phe Gln Phe He 130 135 140 ccg cga gca ate ttc cgc aag ctg ccg ttc taacggaagt tacggaagtt 482 Pro Arg Ala He Phe Arg Lys Leu Pro Phe 15 145 150 acg 485 < 210 > 144 < 211 > 154 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 144 • Asp Asn Glu Ala Gln Trp Arg Asp Gln Ala Leu Ala Val Glu Ala Thr January 5 10 15 Thr Val Asn Tyr Thr Ala Gly Val Ser Val Gly Val Leu Leu Gly Gln 20 20 25 30 Lys Phe Glu Gln Gln Gly His Gly Thr He Val Ala Leu Ser Ser Val 35 40 45 Wing Gly Gln Arg Val Arg Arg Ser Asn Phe Val Tyr Gly Ser Wing Lys 50 55 60 Wing Gly Phe Asp Gly Phe Tyr Thr Gln Leu Gly Glu Wing Leu Arg Gly 65 70 75 80 Ser Gly Wing Asn Val Leu Val Val Arg Pro Gly Gln Val Arg Thr Lys 85 90 95 Met Ser Wing Asp Gly Gly Glu Wing Pro Leu Thr Val Asn Arg Glu Asp 100 105 110 Val Wing Asp Wing Val Tyr Asp Wing Val Val Asn Lys Lys Asp He He 25 115 120 125 ^, tij Phe Val His Pro Leu Phe Gln Tyr Val Ser Phe Wing Phe Gln Phe He 130 135 140 Pro Arg Ala He Phe Arg Lys Leu Pro Phe 145 150 < 210 > 145 < 211 > 259 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (259) < 223 > FRXA00421 < 400 > 145 getggttgaa gactcgaaat gagategace caaceggagt ctttgcatct gacatgtccc 60 gccgacttga gctttcttaa gaaagggctt gaactaaaca atg ctt aac gca gtg 115 Met Leu Asn Ala Val 1 5 ggc aaa gcc caac aac att ctt ctt ggt gga acc tet gag ate ggt 163 Gly Lys Ala Gln Asn He Leu Leu Leu Gly Gly Thr Ser Glu He Gly 10 15 20 att tcc att gtc tcc cgc ttc etc aag cag ggt cca tcc cat gtg acc 211 He Ser He Val Ser Arg Phe Leu Lys Gln Gly Pro Ser His Val Thr 25 30 35 ttg gca gcg cgt aaa gat tcc cca cgc gtg gac gca gca gtc gca gag 259 Leu Ala Ala Arg Lys Asp Ser Pro Arg Val Asp Ala Ala Val Ala Glu 40 45 50 < 210 > 146 < 211 > 53 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 146 Met Leu Asn Ala Val Gly Lys Ala Gln Asn He Leu Leu Leu Gly Gly 1 5 10 15 Thr Ser Glu He Gly Be Ser He Val Ser Arg Phe Leu Lys Gln Gly 20 25 30 Pro Ser His Val Thr Leu Ala Wing Arg Lys Asp Ser Pro Arg Val Asp 35 40 45 Ala Ala Val Ala Glu 50 < 210 > 147 < 211 > 861 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (838) < 223 > RXN02923 < 400 > 147 geatetacat tgaaggaatc cacggagcgc geategaaga catcgttgtg gtgaatgaag 60 aeggttgtga aaccctcaac aaccagcccaa aaggggaaaaccttggccgg ttg age att ctt etc 115 Leu Ser He Leu Leu 1 5 cta ggc gga acc tet gac att gcc ggt gag att gcc acg ttg acg tgt 163 Leu Gly Gly Thr Ser Asp He Ala Gly Glu He Wing Thr Leu Thr Cys 10 15 20 falls ggc gaa gac gtt gtt ttg gct gct cgt cga cca gag gct gca cag 211 His Gly Glu Asp Val Val Leu Ala Wing Arg Arg Pro Glu Wing Ala Gln 25 30 35 • ggc tta gcg gaa gat ctt cga cag cgc ggt gcc here tet gtt cat gtt 259 Gly Leu Wing Glu Asp Leu Arg Gln Arg Gly Wing Thr Ser Val His Val 40 45 50 ttg age ttt gac gcc ca gta cta gac acg falls cga gaa ctt gtg aag 307 Leu Ser Phe Asp Wing Gln Val Leu Asp Thr His Arg Glu Leu Val Lys 55 60 65 aaa here ca ga gac cta gct ggc gag att tcc ctt gcc gtg gtt gct ttt 355 Lys Thr Gln Glu Leu Wing Gly Glu He Ser Leu Wing Val Val Ala Phe 70 75 80 85 ggc ate ttg gga gac caa gaa cgc gca gaa acc gat gag acc cat gcg 403 Gly He Leu Gly Asp Gln Glu Arg Ala Glu Thr Asp Glu Thr His Wing 10 90 95 100 gta gag ate gcc acc gtg gat tac acc gct ca g gtc tcc atg etc act 451 Val Glu He Ala Thr Val Asp Tyr Thr Ala Gln Val Ser Met Leu Thr 105 110 115 • gtg ctt gct gat gag etc cgc gca ca act act cca gc gcg ate gtg 499 Val Leu Wing Asp Glu Leu Arg Wing Gln Thr Thr Pro Wing Wing Val 120 125 130 gcg ttt tcc tcg att gct ggg tgg cgg gcg cgc cgg ect aac tat gtc 547 Wing Phe Be Ser Wing Wing Gly Trp Arg Wing Arg Arg Pro Asn Tyr Val 135 140 145 tat gga tcc acc aag gct ggt etc gat gca ttt tgc ca ggg ctt gca 595 Tyr Gly Ser Thr Lys Wing Gly Leu Asp Wing Phe Cys Gln Gly Leu Wing 15 150 155 160 165 gat age ctg cat ggg here falls gtg cga ttg att att gcg cgt ect ggc 643 Asp Ser Leu His Gly Thr His Val. Arg Leu He He Wing Arg Pro Gly 170 175 180 ttt gtt att ggt tet atg acc acg ggg atg aag ect gct ccg atg tcg 691 Phe Val He Gly Ser Met Thr Thr Gly Met Lys Pro Pro Pro Met Ser 185 190 195 gtg tat cca cga gat gtt gcc gca gct gtt gtt agt gct tat acc tet 739 • Val Tyr Pro Arg Asp Val Ala Ala. Wing Val Val Ser Wing Tyr Thr Ser 200 205 210 aag aag agg age acg acc ttg tgg att ccg gga cgt ctg cgg gtt etc 787 Lys Lys Arg Ser Thr Thr Leu Trp He Pro Gly Arg Leu Arg Val Leu 20 215 220 225 gcc tgg att atg cgg atg gtt ect cgt ccg gtg tgg cgg aag atg cca 835 Wing Trp He Met Arg Met Val Pro, Arg Pro Val Trp Arg Lys Met Pro 230 235 240 245 cgc tagaitacccg ttcagccctc here 861 Arg < 210 > 148 < 211 > 246 < 212 > PRT < 213 > Corynebacterium glutamicum 25 < 400 > 148 Leu Ser He Leu Leu Leu Gly Gly Thr Ser Asp He Wing Gly Glu He 1 5 10 15 Wing Thr Leu Thr Cys His Gly Glu Asp Val Val Leu Wing Wing Arg Arg 20 25 30 Pro Glu Wing Wing Gln Gly Leu Wing Glu Asp Leu Arg Gln Arg Gly Wing 35 40 45 Thr Ser Val His Val Leu Ser Phe Asp Wing Gln Val Leu Asp Thr His 50 55 60 Arg Glu Leu Val Lys Lys Thr Gln Glu Leu Wing Gly Glu He Ser Leu 65 70 75 80 Wing Val Val Wing Phe Gly He Leu Gly Asp Gln Glu Arg Wing Glu Thr 85 90 95 Asp Glu Thr His Wing Val Glu He Wing Thr Val Asp Tyr Thr Wing Gln 100 105 110 Val Ser Met Leu Thr Val Leu Wing Asp Glu Leu Arg Wing Gln Thr Thr 115 120 125 Pro Ala Wing He Val Wing Phe Ser Wing Wing Gly Trp Arg Wing Arg 130 135 140 Arg Pro Asn Tyr Val Tyr Gly Ser Thr Lys Wing Ala Gly Leu Asp Wing Phe 150 155 160 10 145 Cys Gln Gly Leu Wing Asp Ser Leu His Gly Thr His Val Arg Leu He 165 170 175 He Wing Arg Pro Gly Phe Val He Gly Ser Met Thr Thr Gly Met Lys • 180 185 190 Pro Wing Pro Met Ser Val Tyr Pro Arg Asp Val Wing Wing Wing Val Val 195 200 205 Wing Wing Tyr Th r Ser Lys Lys Arg Ser Thr Thr Leu Trp He Pro Gly 210 215 220 Arg Leu Arg Val Leu Wing Trp He Met Arg Met Val Pro Arg Pro Val 225. 230 235 240 Trp Arg Lys Met Pro Arg 15 245 <; 210 > 149 < 211 > 1203 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS • < 222 > (101) .. (1180) < 223 > RXN02922 20 < 400 > 149 cccaccgcgg cgcaagctac cgcctaggcg ctcggaactc caccgccact attgatctca 60 gttccatatc cgcccaacta gtttcccagg gagcccactc atg ate tea ccg caa 115 Met He Ser Pro Gln 1 5 here ate ate gac aat ctt gct cca gtc etc gcg gag ate gca gca acg 163 Thr He He Asp Asn Leu Ala Pro Val Leu Ala Glu He Ala Ala Thr 10 15 20 gct gcg cag cgc gaa cag gat cga gaa ttc age cgt gat ttg gca aag 211 Ala Ala Gln Arg Glu Gln Asp Arg Glu Phe Ser Arg Asp Leu Ala Lys 25 30 35 cag ctt agt gcc ggt ggg ttc act aaa etc cgc att cca gtt gaa ttt 259 25 Gln Leu Be Wing Gly Gly Phe Thr Lys Leu Arg He Pro Val Glu Phe ? é rÁ t ^ Jí Éz £. 40 45 50 ggc ggt ttg ggt ttt age ctt cca gaa gca ttt gag gtg ctg gtg gca 307 Gly Gly Leu Gly Phe Ser Leu Pro Glu Wing Phe Glu Val Leu Val Wing 55 60 65 gcg gcc gca gca gat tea aat ate gcg cag gga ttg cgg ect falls ttc 355 Wing Wing Wing Asp Being Asn He Wing Gln Gly Leu Arg Pro His Phe 70 75 80 85 ttg gca gtg gag age tta ttg ate gct ect tat tea gag cae cgc acc 403 . Leu Ala Val Glu Ser Glu His Arg Thr • Leu Leu He Ala Pro Tyr Ser 90 95 100 aag tgg ctg cga aaa ate gct gag aaa ggc gtg gtc att ggc aat gcg 451 Lys Trp Leu Arg Lys He Wing Glu Lys Gly Val Val He Gly Asn Ala 105 110 115 ttg act gaa gtg gga aac aag cca ggt gag ctg aaa acc aag ate cga 499 Leu Thr Glu Val Gly Asn Lys Pro Gly Glu Leu Lys Thr Lys He Arg 120 125 130 aag gaa ggc gag tet tac gtt etc age gac acc aag ttc tat tcc acg 547 Lys Glu Gly Glu Ser Tyr Val Leu Ser Asp Thr Lys Phe Tyr Ser Thr 135 140 145 ggc agt ctt tac gcc gac tgg att ca gta cat gcg aaa gat gag gaa 595 10 Gly Ser Leu Tyr Wing Asp Trp He Gln Val His Wing Lys Asp Glu Glu "150 155 160 165 gat gat gtt ttc gcc ttt gtt gat cgc gac gca tea ggc gtt gtt 643 Asp Gln Asp Val Phe Wing Phe Val Asp Arg Asp Ala Ser Gly Val Val • 170 175 180 ttg gtg gat tac tgg gac gaa ttt ggg caá cata cta ttt gcc tcc gga 691 Leu Val Asp Tyr Trp Asp Glu Phe Gly Gln Gln Leu Phe Wing Ser Gly 185 190 195 acc age ttc ttt gaa aaa gtc gtg gta gat cca ctg gac att gtc acc 739 Thr Ser Phe Phe Glu Lys Val Val Val Asp Pro Leu Asp He Val Thr 200 205 210 cgt gat tac acc gca ccc age gct tcc cag gcg ctg gcg cag tea cat 787 15 Ar < ? Asp Tyr Thr Ala Pro Ser Ala Phe Gln Ala Leu Ala Gln Ser His 215 220 225 cat ttg tet acg ttg act ggt att tcg cag gca ate acc cgt gac att 835 His Leu Ser Thr Leu Thr Gly He Ser Gln Ala He Thr Arg Asp He 230 235 240 245 gtt acc tat gta caa aac cgc acc cgt att ttc age falls gga agt ggt 883 Val Thr Tyr Val Gln Asn Arg Thr Arg He Phe Ser His Gly Ser Gly 250 255 260 • gac ctt cca cgc ttt gat ccg cag gtg cag gtg gtg ggt gag gtg 931 Asp Leu Pro Arg Phe Asp Pro Gln Val Gln Gln Val Val Gly Glu Val 265 270 275 aaa gcc aag tcg tat gca gtc gag aaa ate ttt cag ggt ttc gca caa 979 20 Lys Ala Lys Ser Tyr Wing Val Glu Lys He Phe Gln Gly Phe Wing Gln 280 285 290 gaa ctg gat ctt gtc gtc gat aag gca aaa gcc ggc act gct acg gag 1027 Glu Leu Asp Leu Val Val Asp Lys Ala Lys Ala Gly Thr Wing Thr Glu 295 300 305 gtc gat ctg gcc gct gtc gac ctg age gcc tac cac gcc cag tta gcg 1075 Val Asp Leu Ala Ala Val Asp Leu Ser Ala Tyr Gln Ala Gln Leu Ala 310 315 320 325 gtg gca ect ttg gtg ctg age cag gcc acc cag gcc ttt gag gtt ggc 1123 Val Wing Pro Leu Val Leu Ser Gln Wing Thr Gln Wing Phe Glu Val Gly 330 335 340 gca gat gcc tta aac ggc ggc falls gtg gct gcc ca ta tac acg ate gga 1171 25 Wing Asp Wing Leu Asn Gly Gly His Val Wing Wing Gln Tyr Thr He Gly 345 350 355 tcc ttg tea tgagecaaga aattttgagc cat 1203 Ser Leu Ser 360 < 210 > 150 < 211 > 360 < 212 > PRT • < 213 > Corynebacterium glutamicum < 400 > 150 Met He Ser Pro Gln Thr He He As Asn Leu Wing Pro Val Leu Wing 1 5 10 15 Glu He Wing Wing Thr Wing Wing Gln Arg Glu Gln Asp Arg Glu Phe Ser 20 25 30 Arg Asp Leu Wing Lys Gln Leu Wing Wing Gly Gly Phe Thr Lys Leu Arg 35 40 45 He Pro Val Glu Phe Gly Gly Leu Gly Phe Ser Leu Pro Glu Wing Phe 50 55 60 Glu Val Leu Val Wing Wing Wing Wing Wing Asp Being Asn He Wing Gln Gly 10 65 70 75 80 Leu Arg Pro His Phe Leu Wing Val Glu Ser Leu Leu He Wing Pro Tyr 85 90 95 • Ser Glu His Arg Thr Lys Trp Leu Arg Lys He Wing Glu Lys Gly Val 100 105 110 Val He Gly Asn Ala Leu Thr Glu Val Gly Asn Lys Pro Gly Glu Leu 115 120 125 Lys Thr Lys He Arg Lys Glu Gly Glu Ser Tyr Val Leu Ser Asp Thr 130 135 140 Lys Phe Tyr Ser Thr Gly Ser Leu Tyr Ala Asp Trp He Gln Val His 145 150 155 160 Wing Lys Asp Glu Glu Asp Gln Asp Val Phe Wing Phe Val Asp Arg Asp 15 165 170 175 Wing Ser Gly Val Val Leu Val Asp Tyr Trp Asp Glu Phe Gly Gln Gln 180 185 190 Leu Phe Wing Ser Gly Thr Ser Phe Phe Glu Lys Val Val Val Asp Pro 195 200 205 Leu Asp He Val Thr Arg Asp Tyr Thr Ala Pro Ser Wing Phe Gln Wing 210 215 220 Leu Wing Gln Ser His His Leu Ser Thr Leu Thr Gly He Ser Gln Ala • 225 230 235 240 He Thr Arg Asp He Val Thr Tyr Val Gln Asn Arg Thr Arg He Phe 245 250 255 Ser His Gly Ser Gly Asp Leu Pro Arg Phe Asp Pro Gln Val Gln Gln 20 260 265 270 Val Val Gly Glu Val Lys Ala Lys Ser Tyr Al to Val Glu Lys He Phe 275 280 285 Gln Gly Phe Wing Gln Glu Leu Asp Leu Val Val Asp Lys Wing Lys Wing 290 295 300 Gly Thr Wing Thr Glu Val Asp Leu Wing Wing Val Asp Leu Ser Wing Tyr 305 310 315 320 Gln Wing Gln Leu Wing Val Wing Pro Leu Val Leu Ser Gln Wing Thr Gln 325 330 335 Wing Phe Glu Val Gly Wing Asp Wing Leu Asn Gly Gly His Val Wing Wing 340 345 350 Gln Tyr Thr He Gly Ser Leu Ser 25 355 360 <; 210 > 151 < 211 > 516 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS • < 222 > (101) .. (493) < 223 > RXN03065 < 400 > 151: ctca gcgtgcgtgg cagtgtttge actgatcgtg 60 jetaa gctaggtcgc atg ate age att gga 115 Met He Ser He Gly 1 5 acc gac etc gtt falls att tcg gcg ttc gca gag cag ctt gca cag ccg 163 Thr Asp Leu Val His He Ser Ala Phe Ala Glu Gln Leu Ala Gln Pro 10 15 20 gga agt tcc ttc atg gag gtg ttt tcc gca ggg gag cgt cgt aaa gca 211 10 Gly Being Being Phe Met Glu Val Phe Being Wing Gly Glu Arg Arg Lys Wing 25 30 35 aat gaa cgc cag gca age cgc tac gcc gag cat ttg gcg ggg cgg tgg 259 Asn Glu Arg Gln Wing Being Arg Tyr Wing Glu His Leu Wing Gly Arg Trp 40 45 50 gcg gca aaa gaa tcc ttt att aag gcc tgg tea cag gcc att tat ggc 307 Ala Ala Lys Glu Ser Phe He Lys Ala Trp Ser Gln Ala He Tyr Gly 55 60 65 cag cca ccc gtg ate gcc gaa gaa gcc gtg gtg tgg cgg gac ate gaa 355 Gln Pro Pro Val He Wing Glu Glu Wing Val Val Trp Arg Asp He Glu 70 75 80 85 gtt cgc gca gac gcg tgg ggg cgc gtc gcg ate gaa ttg gcg ccc gaa 403 15 Val Arg Wing Asp Wing Trp Gly Arg Val Wing He Glu Leu Wing Pro Glu 90 95 100 ttg gcc gca gtg gtc cgg gaa tcc ate ggg gag ttt tc age age ttg 451 Leu Ala Ala Val Val Arg Glu Ser He Gly Glu Phe Ser Ser Ser Leu 105 110 115 age ate age falls gac ggc gac tac gcg gtg gaa cgt gcg tgt 493 Ser He Ser His Asp Gly Asp Tyr Ala Val Glu Arg Ala Cys 120 125 130 tgactateca gtagccacgg aga 516 < 210 > 152 < 211 > 131 20 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 152 Met He Ser Be Gly Thr Asp Leu Val His He Ser Wing Phe Wing Glu 1 5 10 15 Gln Leu Wing Gln Pro Gly Ser Being Phe Met Glu Val Phe Ser Wing Gly 20 25 30 Glu Arg Arg Lys Wing Asn Glu Arg Gln Wing Ser Arg Tyr Ala Glu His 35 40 45 Leu Wing Gly Arg Trp Wing Wing Lys Glu Ser Phe He Lys Wing Trp Ser 50 55 60 25 Gln Wing He Tyr Gly Gln Pro Pro Val He Wing Glu Glu Wing Val Val 65 70 75 80 Trp Arg Asp He Glu Val Arg Wing Asp Wing Trp Gly Arg Val Wing 85 90 95 Glu Leu Wing Pro Glu Leu Wing Wing Val Val Glu Ser He Gly Glu 100 105 110 Phe Ser Ser Leu Ser Be Ser His Asp Gly Asp Tyr Ala Val Glu 115 120 125 Arg Ala Cys 130 • < 210 > 153 < 211 > 543 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (520) < 223 > RXN03132 10 < 400 > 153 taaettattt atacataaaa acacaataaa aaccgcacac gcggegaaac ttcaataaat 60 ccctagaictg icaaaaaatgg ttaggctaac cttatttcca atg aat gtg aat caa 115 Met Asn Val Asn Gln • 1 5 cag ttg gga gcc cgc acc gcc atg aac cae ect gag acc gca acc gtc 163 Gln Leu Gly Ala Arg Thr Wing Met Asn His Pro Glu Thr Wing Thr Val 10 15 20 ctt cgc tcc ate tet gac atg gtt age acc gaat acc aat ccg cgc cgt 211 Leu Arg Ser He Be Asp Met Val Ser Thr Glu Thr Asn Pro Arg Arg 25 30 35 aaa age cgc etc gag cag etc att tac gcc acc gcc age gcc tgg ccc 259 15 Lys Ser Arg Leu Glu Gln Leu He Tyr Wing Thr Wing Being Wing Trp Pro 40 45 50 falls tac ccc att gcc falls gca gcc cag gcc gcg gtg cata tta gcc agg 307 His Tyr Pro He Ala Ala Ala Ala Gln Ala Ala Val Gln Leu Ala Arg 55 60 65 cca atg cgg gtt ttt gag etc cag age ttt gaa ggc gtc aag falls gca 355 Pro Met Arg Val Phe Glu Leu Gln Ser Phe Glu Gly Val Lys His Wing 70 75 80 85 etc falls falls gat gat ctt cgc ccc gcc etc gaa tgg gac ate atg gga 403 Leu His His As As Leu Arg P ro Ala Leu Glu Trp Asp He Met Gly 90 95 100 ttt ccc gaa tcc ccc gac acg ctg ccc att ttg etc agt gac ctg cgc 451 20 Phe Pro Glu Pro Pro Asp Thr Leu Pro He Leu Leu Ser Asp Leu Arg 105 110 115 gac ccc ect tac gcc acc act gct gtg cca ect cac tc acc cca ccc 499 Asp Pro Pro Tyr Wing Thr Thr Wing Val Pro Pro Gln Ser Thr Pro Arg 120 125 130 tcc gct falls cga tcc here cat tgacgcttcc aggcgccacc gcg 543 Ser Ala His Arg Ser Thr His 135 140 < 210 > 154 < 211 > 140 < 212 > PRT 2 ^ < 213 > Corynebacterium glutamicum . ».,.,.,. - * - '• a? T-a < 400 > 154 Met Asn Val Asn Gln Gln Leu Gly Ala Arg Thr Ala Met Asn His Pro 1 5 10 15 Glu Thr Ala Thr Val Leu Arg Ser He Be Asp Met Val Ser Thr Glu 20 25 30 Thr Asn Pro Arg Arg Lys Ser Arg Leu Glu Gln Leu He Tyr Ala Thr 35 40 45 Wing Ser Wing Trp Pro His Tyr Pro He Ala Ala Ala Ala Gln Ala Ala 50 55 60 Val Gln Leu Ala Arg Pro Met Arg Val Phe Glu Leu Gln Ser Phe Glu 65 70 75 80 Gly Val Lys His Ala Leu His His As Asu Leu Arg Pro Ala Leu Glu 85 90 95 Trp Asp He Met Gly Phe Pro Glu Ser Pro Asp Thr Leu Pro He Leu 100 105 110 Leu Ser Asp Leu Arg Asp Pro Pro Tyr Ala Thr Thr Wing Val Pro Pro 115 120 125 Gln Ser Thr Pro Arg Ser Wing His Arg Ser Thr His 130 135 140 < 210 > 155 < 211 > 461 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (438) < 223 > RXN03157 < 400 > 155 ggc falls etc gac ate gtg acc cgc gcc gcc gcg cat ttt age gaa gtc 48 Gly His Leu Asp He Val Thr Arg Ala Wing Ala Gln Phe Ser Glu Val 1 5 10 15 acc ate ttg gtc acc gcc aac ccc aac aaaaac a t a g a t g e c t g tc acc 96 Thr He Leu Val Thr Ala Asn Pro Asn Lys Asn Ser Gly Leu Phe Thr 20 25 30 gtc gca gaa cgc atg gat etc ate cgc gaa tcc acc gca falls ctg gac 144 Val Ala Glu Arg Met Asp Leu He Arg Glu Ser Thr Ala His Leu Asp 35 40 45 aac gta aaa gta gac act tgg gcc tea ctg etc gtg gat tac acc acc 192 Asn Val Lys Val Asp Thr Trp Wing Ser Leu Leu Val Asp Tyr Thr Thr 50 55 60 gaa cat ggc ate ggc gcc cta gtc aaa ggc ctg cga age tcc etc gac 240 Glu His Gly He Gly Ala Leu Val Lys Gly Leu Arg Ser Ser Leu Asp 65 70 75 80 tac gaa tac gag etc ccc atg gca cag atg aac agg cga etc acg ggc 288 Tyr Glu Tyr Glu Leu Pro Met Wing Gln Met Asn Arg Arg Leu Thr Gly 85 90 95 gta gac acc ttc ttc etc etc acc gac gag aaa tac ggc tac gtc age 336 Val Asp Thr Phe Phe Leu Leu Thr Asp Glu Lys Tyr Gly Tyr Val Ser 100 105 110 tcc here ctg tgc aaa gaa gtt gcc cgc ttc ggt ggc gat gtc tcc ggc 384 Ser Thr Leu Cys Lys Glu Val Wing Arg Phe Gly Gly Asp Val Ser Gly 115 120 125 etc cta ect gag gta gtg gca aaa gcc gtg here gaa aaa tac age aac 432 Leu Leu Pro Glu Val Val Ala Lys Ala Val Thr Glu Lys Tyr Ser Asn 130 135 140 cag drops tagtttcttt tgcatcaagc gtc 461 Gln His 145 < 210 > 156 < 211 > 146 < 212 > PRT • < 213 > Corynebacterium glutamicum < 400 > 156 Gly His Leu Asp He Val Thr Arg Ala Wing Gln Phe Ser Glu Val 1 5 10 15 Thr He Leu Val Thr Wing Asn Pro Asn Lys Asn Ser Gly Leu Phe Thr 20 25 30 Val Wing Glu Arg Met Asp Leu He Arg Glu Ser Thr Ala His Leu Asp 35 40 45 Asn Val Lys Val Asp Thr Trp Wing Ser Leu Leu Val Asp Tyr Thr Thr 50 55 60 Glu His Gly He Gly Wing Leu Val Lys Gly Leu Arg Ser Ser Leu Asp 10 65 70 75 80 Tyr Glu Tyr Glu Leu Pro Met Wing Gln Met Asn Arg Arg Leu Thr Gly 85 90 95 • Val Asp Thr Phe Phe Leu Leu Thr Asp Glu Lys Tyr Gly Tyr Val Ser 100 105 110 Ser Thr Leu Cys Lys Glu Val Wing Arg Phe Gly Gly Asp Val Ser Gly 115 120 125 Leu Leu Pro Glu Val Val Ala Lys Ala Val Thr Glu Lys Tyr Ser Asn 130 135 140 Gln His 145 15 < 210 > 157 < 211 > 1206 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1183) • < 223 > RXN00934 < 400 > 157 20 ccaacccctg tggtttggtg atttggatcc ggagcgtctc aagcgctcta gggageagac 60 aaatgttcac aaaccggtgg cattacagga ggacaattag gtg cga att gga atg 115 Val Arg He Gly Met 1 5 gtc tgc ccg tac tcc tcc gat gag ccg ggc ggt gtt ca gcg cat ate 163 Val Cys Pro Tyr Ser Phe Asp Glu Pro Gly Gly Val Gln Wing His He 10 15 20 ctt gac tta gcg cga acc ttc att gcc ca ggc cat gag gtt cag gtg 211 Leu Asp Leu Wing Arg Thr Phe He Wing Gln Gly His Glu Val Gln Val 25 30 35 ctt ggt ccg tgt agt gcg gat acg cag gtg ccc gat ttc gtg gtg cgc 259 Leu Gly Pro Cys Ser Wing Asp Thr Gln Val Pro Asp Phe Val Val Arg 25 40 45 50 ggt ggt ggc age ate ccg att ccg tac aat ggc tcg gtt gcc cgc ttg 307 Gly Gly Gly Ser He Pro Pro Tyr Asn Gly Ser Val Wing Arg Leu 55 60 65 age ttt ggg ccg aaa atg ttc aag gcc gtg cgc acg ttc etc cgc gaa 355 Ser Phe Gly Pro Lys Met Phe Lys Wing Val Arg Thr Phe Leu Arg Glu 70 75 80 85 ggc aac ttc gat gtg ctg cat ate cat gaa ccg aat tea cca agt ttt 403 Gly Asn Phe Asp Val Leu His He His G Lu Pro Asn Ser Pro Be Phe • 90 95 100 tcc atg gcg gcg cta cgc ttt gcg gaa ggc ccc ate gtt gct act tac 451 Ser Met Wing Ala Leu Arg Phe Wing Glu Gly Pro He Val Wing Ala Thr Tyr 105 110 115 falls gcc tcc agt age gga tcg aag ctg etc aag gct ttc tta cca gtg 499 His Wing Being Ser Gly Ser Lys Leu Leu Lys Wing Phe Leu Pro Val 120 125 130 ctt tcg ccc atg ctg gag aaa gtg cgc gca ggc ate gcc gtg tet gaa 547 Leu Ser Pro Met Leu Glu Lys Val Arg Wing Gly He Wing Val Ser Glu 135 140 145 atg gct cgg cgc tgg cag gtg gag ca gtc ggc ggc gat ccc gtg ctg 595 Met Ala Arg Arg Trp Gln Val Glu Gln Val Gly Gly Asp Pro Val Leu 10 150 155 160 165 ate ccc aac ggg gta gag acc tcc atg ttc aaa gcc gcg cgc ca ate 643 He Pro Asn Gly Val Glu Thr Ser Met Phe Lys Wing Wing Arg Gln He 170 175 180 gaa ccg aat gat ect gta gag ate gtc ttt tg ggt cgc etc gat gag 691 Glu Pro Asn Asp Pro Val Glu He Val Phe Leu Gly Arg Leu Asp Glu 185 190 195 tcc cgc aaa ggc etc gac ate etc ctc cgc gct ctg acc agg ctg gat 739 Ser Arg Lys Gly Leu Asp He Leu Leu Arg Leu Leu Thr Arg Leu Asp 200 205 210 cgc ccg ttt acc tgc acc gtc att ggc ggc ggc acc ccg cga gaa gtc 787 Arg Pro Phe Thr Cys Thr Val He Gly Gly Gly Thr Pro Arg Glu Val 15 215 220 225 gcc ggc ate aac ttt gtg ggc cgc gtc age gat gag gaa aag gca gca 835 Wing Gly He Asn Phe Val Gly Arg Val Ser Asp Glu Glu Lys Ala Ala 230 235 240 245 ate tta ggt cgc gca gac ate tat gtc gca ccc aac acc ggc ggo gaa 883 He Leu Gly Arg Wing Asp He Tyr Val Wing Pro Asn Thr Gly Gly 250 255 260 age ttc ggc ate gtg cta gtt gaa gcg atg gcc gcg gga tgc gct gtc 931 Ser Phe Gly He Val Leu Val Glu Wing Ala Wing Wing Gly Cys Wing Val 265 270 275 gtc gcc age gac cta gaa gcg ttc tcc ctg gtc acc gat tet g aa gcc 979 Val Ala Ser Asp Leu Glu Ala Phe Ser Leu Val Thr Asp Ser Glu Wing 20 280 285 290 gca cag cca gcg ggc gtg cta ttt aaa acc ggc tea gac gcc gac cta 1027 Wing Gln Pro Wing Gly Val Leu Phe Lys Thr Gly Ser Asp Wing Asp Leu 295 300 305 gcc aaa aaa ctt caa gcg ctt ate gac gac ccc tcc tcc cgt tcc acg 1075 Wing Lys Lys Leu Gln Wing Leu He Asp Asp Pro Ser Ser Arg Ser Thr 310 315 320 325 ctt ate gcc gcg ggg cta aag cgc gca aac gcc tac gac tgg tcg here 1123 Leu He Wing Wing Gly Leu Lys Arg Wing Asn Wing Tyr Asp Trp Ser Thr 330 335 340 gta tcc acc gg gtc atg gtc tat tat gaa acc att gcg ate gac aaa 1171 Val Be Thr Gln Val Met Wing Val Tyr Glu Thr He Wing He Asp Lys 25 345 350 355 ^^^^ Ü? gtg agg ctt gga tgacccttgt ttacctcctc ate 1206 Val Arg Leu Gly 360 < 210 > 158 < 211 > 361 < 212 > PRT < 213 > Corynebacterium glutamicum • < 400 > 158 Val Arg He Gly Met Val Cys Pro Tyr Ser Phe Asp Glu Pro Gly Gly 1 5 10 15 Val Gln Wing His He Leu Asp Leu Wing Arg Thr Phe He Wing Gln Gly 20 25 30 His Glu Val Gln Val Leu Gly Pro Cys Ser Wing Asp Thr Gln Val Pro 35 40 45 Asp Phe Val Val Arg Gly Gly Gly Ser He Pro Pro Tyr Asn Gly 50 55 60 Ser Val Wing Arg Leu Ser Phe Gly Pro Lys Met Phe Lys Wing Val Arg 65 70 75 80 10 Thr Phe Leu Arg Glu Gly Asn Phe Asp Val Leu His He His Glu Pro 85 90 95 Asn Ser Pro Be Phe Ser Met Ala Ala Leu Arg Phe Ala Glu Gly Pro 100 105 110 He Val Ala Thr Tyr His Ala Ser Ser Gly Ser Lys Leu Leu Lys 115 120 125 Wing Phe Leu Pro Val Leu Ser Pro Met Leu Glu Lys Val Arg Wing Gly 130 135 140 He Wing Val Ser Glu Met Wing Arg Arg Trp Gln Val Glu Gln Val Gly 145 150 155 160 Gly Asp Pro Val Leu He Pro Asn Gly Val Glu Thr Ser Met Phe Lys 165 170 175 15 Wing Wing Arg Gln He Glu Pro Asn Asp Pro Val Glu He Val Phe Leu 180 185 190 Gly Arg Leu Asp Glu Ser Arg Lys Gly Leu Asp He Leu Leu Arg Ala 195 200 20 5 Leu Thr Arg Leu Asp Arg Pro Phe Thr Cys Thr Val He Gly Gly Gly 210 215 220 Thr Pro Arg Glu Val Wing Gly He Asn Phe Val Gly Arg Val Ser Asp 225 230 235 240 Glu Glu Lys Ala Wing He Leu Gly Arg Wing Asp He Tyr Val Pro Wing 245 250 255 Asn Thr Gly Gly Glu Ser Phe Gly He Val Val Val Vallu Ala Met Wing 260 265 270 20 Wing Gly Cys Wing Val Val Wing Ser Asp Leu Glu Wing Phe Ser Leu Val 275 280 285 Thr Asp Ser Glu Ala Ala Gln Pro Ala Gly Val Leu Phe Lys Thr Gly 290 295 300 Ser Asp Wing Asp Leu Wing Lys Lys Leu Gln Wing Leu He Asp Asp Pro 305 310 315 320 Ser Ser Arg Ser Thr Leu He Wing Wing Gly Leu Lys Arg Ala Asn Ala 325 330 335 Tyr Asp Trp Ser Thr Val Ser Thr Gln Val Met Wing Val Tyr Glu Thr 340 345 350 He Wing He Asp Lys Val Arg Leu Gly 355 360 25 < 210 > 159 < 211 > 1320 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1297; • < 223 > RXN00792 < 400 > 159 caccttttggt igctg; agecag g <? Cacccagg cctttgaggt tggcgcatgat < gccttaaacg 60 gcggccacgt < ggctgcccaa t < acactgatcg galtccttgtc atg age caa gaa att 115 Met Ser Gln Glu He 1 5 ttg age cat ttt gca ccc gca tta gag cgc att cga age ggc gcc gtc 163 Leu Ser His Phe Ala Pro Ala Leu Glu Arg He Arg Ser Gly Ala Val 10 15 20 gag cgc gaa cag cag cgc gcc ttg cca gtg gaa gag att aaa gag ctg 211 Glu Arg Glu Gln Gln Arg Ala Leu Pro Val Glu Glu He Lys Glu Leu 10 25 30 35 gta gag cta ggt ttt act ggg ctt cga gtg ccc gaa gaa cta ggc ggt 259 Val Glu Leu Gly Phe Thr Gly Leu Arg Val Pro Glu Glu Leu Gly Gly 40 45 50 gcg ggc gct tcc ctg gaa age gta gtt gag tta ctg ate gag ate gcg 307 Ala Gly Ala Ser Leu Glu Ser Val Val Glu Leu Leu He Glu He Ala 55 60 65 ggc gcc gat tcc aat ate gcc ca gcc ctg cgc gga cat ttt gcc ttc 355 Gly Wing Asp Being Asn He Wing Gln Wing Leu Arg Gly His Phe Wing Phe 70 75 80 85 gtg gaa cta etc ctg gaa gcg ccg gag age gaa ttc cgc acc cat tgg 403 Val Glu Leu Leu Leu Glu Ala Pro Glu Ser Glu Phe Arg Thr His Trp 15 90 95 100 ctc cgc gaa gtc gcc acc gga aga ctt gtg ggc aac gcc gaa agt gag 451 Leu Arg Glu Val Wing Thr Gly Arg Leu Val Gly Asn Wing Glu Ser Glu 105 110 115 aaa cgc ggc gtt tac ggc gat ccg cag acc ttc ate gat gag gtg gag 499 Lys Arg Gly Val Tyr Gly Asp Pro Gln Thr Phe He Asp Glu Val Glu 120 125 130 act gaa aac gga ccg att ttc gtg etc aac ggc act aag ttt tat acc 547 Thr Glu Asn Gly Pro He Phe Val Leu Asn Gly Thr Lys Phe Tyr Thr 135 140 145 acc ggc acc tat ttt gcg gac tac ac tgg acc acc gcg ctg ctg cgc 595 Thr Gly Thr Tyr Phe Wing Asp Tyr Thr Trp Thr Thr Wing Leu Leu Arg 20 150 155 160 165 aac ctt aac ggc caa gaa act ttg gtc agt ttg ccg gtc gat ctg cae 643 Asn Leu Asn Gly Gln Glu Thr Leu Val Ser Leu Pro Val Asp Leu His 170 175 180 gcg gcg gcg gtt g gat gtt gat gat tgg age ggg ttt ggg caa aag 691 Wing Pro Gly Val Asp Val Wing Asp Asp Trp Ser Gly Phe Gly Gln Lys 185 190 195 etc acc gcc tet gga acg acc acg ttt aaa gac ctg gag gtg gat ccg 739 Leu Thr Ala Ser Gly Thr Thr Thr Phe Lys Asp Leu Glu Val Asp Pro 200 205 210 cgg tgg ate att cca cgc act gat gcg ccc acg ctg gtg tgg acg tat 787 Arg Trp He He Pro Arg Thr Asp Wing Pro Thr Leu Val Trp Thr Tyr 25 215 220 225 ctg cag ctg age ctg ctg acc gtg ctg gtt ggc agt gcc gca gca gct 835 Leu Gln Leu Ser Leu Leu Thr Val Leu Val Gly Ser Ala Ala Ala Ala 230 235 240 245 gtc gat gag gtg gtt gcc cgc gcc cacc tcc tcc acc aga gcg tgg 883 Val Asp Glu Val Val Ala Arg Ala Gln Ser Ser Thr Arg Asn Ala Trp 250 255 260 aac ect ggc gtc gag cgc cgc age gat ccg gcc gc acc ata gcg ate 931 Asn Pro Gly Val Glu Arg Arg Ser Asp Pro Wing Wing Thr He Wing He 265 270 275 ggc gac gca cgc age cg gtc acc gtt att cgt gga gcg ctt etc gac 979 Gly Asp Ala Arg Be Arg Val Thr Val He Arg Gly Ala Leu Leu Asp 280 285 290 gcc acc cgc falls gtt tcc aac gcc gcc acg ate gta acc ccc gaa gcc 1027 Ala Thr Arg His Val Ser Asn Ala Ala Thr He Val Thr Pro Glu Ala 295 300 305 ttc aac gag gcg gac gct att gtt gc gcg etc tgg ccc tet gtc tcc 1075 Phe Asn Glu Wing Asp Wing He Val Wing Wing Leu Trp Pro He Val Ser 310 315 320 325 gga ca gct tg gtg gtg here tcc aac gtt ttc gat gcg gtg ggt gca gct 1123 Gly Gln Wing Leu Val Val Thr Ser Asn Val Phe Asp Wing Val Gly Wing 330 335 340 tet gca gtg ctt ggt gag cat tcc att gat cgc falls tgg cgc aat gtg 1171 Ser Wing Val Leu Gly Glu His Ser He Asp Arg His Trp Arg Asn Val 345 350 355 cgt acc gtg tcc tea aac aac ccg gtg ttc ctg gcc aag aat gca gtg 1219 Arg Thr Val Ser Ser Asn Asn Pro Val Phe Leu Ala Lys Asn Ala Val 360 365 370 ggg gag tat gcc etc aac ggc act ect gtg ggt acc aac att ggt aaa 1267 Gly Glu Tyr Ala Leu Asn Gly Thr Pro Val Gly Thr Asn He Gly Lys 375 380 385 gca ctg age cgt ccg gtg age cta age age tagacgtgtg atttcgctgg 1317 Ala Leu Ser Arg Pro Val Ser Leu Ser Ser 390 395 ttt 1320 < 210 > 160 < 211 > 399 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 160 Met Ser Gln Glu He Leu Ser His Phe Wing Pro Wing Leu Glu Arg He 1 5 10 15 Arg Ser Gly Wing Val Glu Arg Glu Gln Gln Arg Wing Leu Pro Val Glu 20 25 30 Glu He Lys Glu Leu Val Glu Leu Gly Phe Thr Gly Leu Arg Val Pro 35 40 45 Glu Glu Leu Gly Gly Wing Gly Wing Ser Leu Glu Ser Val Val Glu Leu 50 55 60 Leu He Glu He Wing Gly Wing Asp Ser Asn He Wing Gln Wing Leu Arg 65 70 75 80 Gly His Phe Ala Phe Val Glu Leu Leu Leu Glu Ala Pro Glu Ser Glu 85 90 95 Phe Arg Thr His Trp Leu Arg Glu Val Ala Thr Gly Arg Leu Val Gly 100 105 110 sn Ala Glu Ser Glu Lys Arg Gly Val Tyr Gly Asp Pro Gln Thr Phe 115 120 125 He Asp Glu Val Glu Thr Glu Asn Gly Pro He Phe Val Leu Asn Gly 130 135 140 Thr Lys Phe Tyr Thr Thr Gly Thr Tyr Phe Wing Asp Tyr Thr Trp Thr 145 150 155 160 Thr Ala Leu Leu Arg Asn Leu Asn Gly Gln Glu Thr Leu Val Ser Leu 165 170 175 Pro Val Asp Leu His Wing Pro Gly Val Asp Val Wing Asp Asp Trp Ser 180 185 190 Gly Phe Gly Gln Lys Leu Thr Wing Ser Gly Thr Thr Thr Phe Lys Asp 195 200 205 Leu Glu Val Asp Pro Arg Trp He He Pro Arg Thr Asp Wing Pro Thr 210 215 220 Leu Val Trp Thr Tyr Leu Gln Leu Ser Leu Leu Thr Val Leu Val Gly 225 230 235 240 Ser Wing Wing Wing Wing Val Asp Glu Val Val Wing Arg Ala Gln Ser Ser 245 250 255 Thr Arg Asn Wing Trp Asn Pro Gly Val Glu Arg Arg Ser Asp Pro Wing 260 265 270 Wing Thr He Wing He Gly Asp Wing Arg Ser Arg Val Thr Val He Arg 275 280 285 10 Gly Ala Leu Leu Asp Wing Thr Arg His Val Ser Asn Wing Wing Thr He 290 295 300 Val Thr Pro Glu Wing Phe Asn Glu Wing Asp Wing He Val Wing Wing Leu 305 310 315 320 • Trp Pro He Val Ser Gly Gln Wing Leu Val Val Thr Ser Asn Val Phe 325 330 335 Asp Wing Val Gly Wing Wing Val Leu Gly Glu His Ser He Asp Arg 340 345 350 His Trp Arg Asn Val Arg Thr Val Ser Ser Asn Asn Pro Val Phe Leu 355 360 365 Wing Lys Asn Wing Val Gly Glu Tyr Ala Leu Asn Gly Thr Pro Val Gly 370 375 380 15 Thr Asn He Gly Lys Ala Leu Ser Arg Pro Val Ser Leu Ser Ser 385 390 395 <; 210 > 161 < 211 > 969 < 212 > DNA < 213 > Corynebacterium glutamicum ^ < 220 > < 221 > CDS < 222 > (101) .. (946) < 223 > RXN00931 20 < 400 > 161 ccgtaaccta atcgttgaaa catcacctta ttgctgggct ttgeaegeta ctctttgtga 60 gtaacctcac cgaagtgcat aaattaattg ggagtgatca gtg aaa act att gaa 115 Val Lys Thr He Glu 1 5 gat att ttg acc ttg gaa gaa ate gac cgc gat att tac cgt ggt ccc 163 Asp He Leu Thr Leu Glu Glu He Asp Arg Asp He Tyr Arg Gly Pro 10 15 20 gtt ate gaa tet tat tta gcc agg act ttc ggt ggc cag gtc gct gcc 211 Val He Glu Ser Tyr Leu Ala Arg Thr Phe Gly Gly Gln Val Wing Ala 25 30 35 25 ca gct tta gta gca gca acca cat act gtt gat aaa gcc ttt act gtg 259 Gln Wing Leu Val Wing Wing Thr His Thr Val Asp Lys Wing Phe Thr Val 40 45 50 cat tet ttg cat ggc tac ttt ata gct ect ggt gat cca here gca ccc 307 His Ser Leu His Gly Tyr Phe He Wing Pro Gly Asp Pro Thr Wing Pro 55 60 65 gca att tat tta gtg gat cga gtt cgc gac gga aaa age tac gtc acc 355 Ala He Tyr Leu Val Asp Arg Val Arg Asp Gly Lys Ser Tyr Val Thr 70 75 80 85 cgc tcg gtg cgt ggc ate caa gac ggc gaa gta ate ttc age atg cag 403 Arg Ser Val Arg Gly He Gln Asp Gly Glu Val He Phe Ser Met Gln 90 95 100 gcc age ttt cat cgt ggg gat gaa ggc att gag falls atg gac aag atg 451 Wing Ser Phe His Arg Gly Asp Glu Gly He Glu His Met Asp Lys Met 105 110 115 cgt aaa gtt cca gct ect gat gag ate aag gga a gta gta gaa cgt atg 499 Arg Lys Val Pro Wing Pro Asp Glu He Lys Gly Thr Val Glu Arg Met 120 125 130 ccg ate tea agt agg cga gtg ctt gat gaa tgg gcg gaa tgg gat ate 547 Pro He Ser Ser Arg Arg Val Leu Asp Glu Trp Wing Glu Trp Asp He 135 140 145 cgc gtt att ccg cag gat cata tta gaa etc age gat ttc acc gct act 595 Arg Val He Pro Gln Asp Gln Leu Glu Leu Be Asp Phe Thr Ala Thr 150 155 160 165 gag ca gct gtg tgg att cgg tgc acc gct gat ctt ccg gat aat ccc 643 Glu Gln Wing Val Trp He Arg Cys Thr Wing Asp Leu Pro Asp Asn Pro 170 175 180 acc ttc falls to tgc tea ctg act tat ctg tcc gat atg act ttg ctg 691 Thr Phe His Gln Cys Ser Leu Thr Tyr Leu Ser Asp Met Thr Leu Leu 185 190 195 cat agt gcc ctg gtg cca falls cca ggt gag aaa atg cag atg gcc tea 739 His Ser Wing Leu Val Pro His Pro Gly Glu Lys Met Gln Met Wing Ser 200 205 210 ctt gat fall gct gtg tgg ttc ctg cgt ccc ttc cgc gtc gat gaa tgg 787 Leu Asp His Wing Val Trp Phe Leu Arg Pro Phe Arg Val Asp Glu Trp 215 220 225 ttg ctt tat gat cag cgc tet cca tcg gcc tea agt ggg cga gcc ttg 835 Leu Leu Tyr Asp Gln Arg Ser Pro Ser Ala Ser Ser Gly Arg Ala Leu 230 235 240 245 act falls ggg cgg ctt ttc aac cag cag gga gat ttg gtc gct att gtc 883 Thr His Gly Arg Leu Phe Asn Gln Gln Gly Asp Leu Val Wing He Val 250 255 260 aat cag gag gga atg acc cgc here etc falls gag ggt gcg caa tea att 931 Asn Gln Glu Gly Met Thr Arg Thr Leu His Glu Gly Wing Gln Ser He 265 270 275 ccg atg cgc aaa gac taaaatgcag cgaacttgaa gat 969 Pro Met Arg Lys Asp 280 < 210 > 162 < 211 > 282 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 162 Val Lys Thr He Glu Asp He Leu Thr Leu Glu Glu He Asp Arg Asp 1 5 10 15 He Tyr Arg Gly Pro Val He Glu Ser Tyr Leu Ala Arg Thr Phe Gly 20 25 30 Gly Gln Val Ala Ala Gln Ala Leu Val Ala Wing Thr His Thr Val Asp 35 40 45 Lys Wing Phe Thr Val His Ser Leu His Gly Tyr Phe He Wing Pro Gly 50 55 60 Asp Pro Thr Wing Pro Wing He Tyr Leu Val Asp Arg Val Arg Asp Gly 65 70 75 80 Lys Ser Tyr Val Thr Arg Ser Val Arg Gly He Gln Asp Gly Val 85 90 95 • He Phe Ser Met Gln Wing Ser Phe His Arg Gly Asp Glu Gly He Glu 100 105 110 His Met Asp Lys Met Arg Lys Val Pro Wing Pro Asp Glu He Lys Gly 115 120 125 Thr Val Glu Arg Met Pro He Ser Ser Arg Arg Val Leu Asp Glu Trp 130 135 140 Wing Glu Trp Asp He Arg Val He Pro Gln Asp Gln Leu Glu Leu Ser 145 150 155 160 Asp Phe Thr Ala Thr Glu Gln Wing Val Trp He Arg Cys Thr Wing Asp 165 170 175 Leu Pro Asp Asn Pro Thr Phe His Gln Cys Ser Leu Thr Tyr Leu Ser 10 180 185 190 Asp Met Thr Leu Leu His Ser Wing Leu Val Pro His Pro Gly Glu Lys 195 200 205 M et Gln Met Wing Ser Leu Asp His Wing Val Trp Phe Leu Arg Pro Phe • 210 215 220 Arg Val Asp Glu Trp Leu Leu Tyr Asp Gln Arg Ser Pro Ser Wing Ser 225 230 235 240 Ser Gly Arg Ala Leu Thr His Gly Arg Leu Phe Asn Gln Gln Gly Asp 245 250 255 Leu Val Wing He Val Asn Gln Glu Gly Met Thr Arg Thr Leu His Glu 260 265 270 Gly Wing Gln Ser He Pro Met Arg Lys Asp 15 275 280 < 210 > 163 < 211 > 969 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS ^ < 222 > (101) .. (946) < 223 > FRXA00931 20 < 400 > 163 ccgtaaccta atcgttgaaa catcacctta ttgctgggct ttgeaegeta ctctttgtga 60 gtaacctcac cgaagtgcat aaattaattg ggagtgatca gtg aaa act att gaa 115 Val Lys Thr He Glu 1 5 gat att ttg acc ttg gaa gaa ate gac cgc gat att tac cgt ggt ccc 163 Asp He Leu Thr Leu Glu Glu He Asp Arg Asp He Tyr Arg Gly Pro 10 15 20 gtt ate gaa tet tat tta gcc agg act ttc ggt ggc cag gtc gct gcc 211 Val He Glu Ser Tyr Leu Wing Arg Thr Phe Gly Gly Gln Val Wing Wing 25 30 35 ca gct tta gta gca gca acg cat act gtt gat aaa gcc ttt act gtg 259 25 Gln Ala Leu Val Ala Ala Thr His Thr Val Asp Lys Ala Phe Thr Val cat tet ttg cat ggc tac ttt ata gct ect ggt gat cca acca gca ccc 307 His Ser Leu His Gly Tyr Phe He Wing Pro Gly Asp Pro Thr Ala Pro 55 60 65 gca att tat tta gtg gat cga gtt cgc gac gga aaa age tac gtc acc 355 Wing He Tyr Leu Val Asp Arg Val Arg Asp Gly Lys Ser Tyr Val Thr 70 75 80 85 cgc tcg gtg cgt ggc ate ca gac ggc gaa gta ate ttc age atg cag 403 • Arg Ser Val Arg Gly He Gln Asp Gly Glu Val He Phe Ser Met Gln 90 95 100 gcc age ttt cat cgt ggg gat gaa ggc att gag falls atg gac aag atg 451 Wing Being Phe His Arg Gly Asp Glu Gly He Glu His Met Asp Lys Met 105 110 115 cgt aaa gtt cca gct cct gct ect gat gag ate aga gga a gta gata cgt atg 499 Arg Lys Val Pro Pro Pro Asp Glu He Lys Gly Thr Val Glu Arg Met 120 125 130 ccg ate tea agt agg cga gtg ctt gat gaa tgg gcg gaa tgg gat ate 547 Pro He Be Ser Arg Arg Val Leu Asp Glu Trp Wing Glu Trp Asp He 135 140 145 cgc gtt att ccg cag gat cata tta gaa etc age gat ttc acc gct act 595 10 Arg Val He Pro Gln Asp Gln Leu Glu Leu Be Asp Phe Thr Wing Thr 150 155 160 165 gag ca gct gtg tgg att cgg tgc acc gct gat ctt ccg gat aat ccc 643 • Glu Gln Wing Val Trp He Arg Cys Thr Wing Asp Leu Pro Asp Asn Pro 170 175 180 acc ttc falls cag tgc tea ctg act tat ctg tcc gat atg act ttg ctg 691 Thr Phe His Gln Cys Ser Leu Thr Tyr Leu Ser Asp Met Thr Leu Leu 185 190 195 cat agt gcc ctg gtg cca falls cca ggt gag aaa atg cag atg gcc tea 739 His Ser Ala Leu Val Pro His Pro Gly Glu Lys Met Gln Met Ala Ser 200 205 210 ctt gat falls gct gtg tgg ttc ctg cgt ccc ttc cgc gtc gat gaa tgg 787 15 Leu Asp His Wing Val Trp Phe Leu Arg Pro Phe Arg Val Asp Glu Trp 215 220 225 ttg ctt tat gat cag cgc tet cca tcg gcc tea agt ggg cga gcc ttg 835 Leu Leu Tyr Asp Gln Arg Ser Pro Ser Ala Ser Ser Gly Arg Ala Leu 230 235 240 245 act falls ggg cgg ctt tcc aac cag cag gga gat ttg gtc gct att gtc 883 Thr His Gly Arg Leu Phe Asn Gln Gln Gly Asp Leu Val Wing He Val 250 255 260 • aat caa gag gga atg acc cgc here etc falls gag ggt gcg caa tea att 931 Asn Gln Glu Gly Met Thr Arg Thr Leu His Glu Gly Wing Gln Ser He 265 270 275 ccg atg cgc aaa gac taaaatgcag cgaacttgaa gat 969 20 Pro Met Arg Lys Asp 280 < 210 > 164 < 211 > 282 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 164 Val Lys Thr He Glu Asp He Leu Thr Leu Glu Glu He Asp Arg Asp 1 5 10 15 He Tyr Arg Gly Pro Val He Glu Ser Tyr Leu Ala Arg Thr Phe Gly 25 20 25 30 Gly Gln Val Ala Ala Gln Ala Leu Val Ala Ala Thr His Thr Val Asp 35 40 45 Lys Ala Phe Thr Val His Ser Leu His Gly Tyr Phe He Wing Pro Gly 50 55 60 Asp Pro Thr Wing Pro Wing He Tyr Leu Val Asp Arg Val Arg Asp Gly 65 70 75 80 Lys Ser Tyr Val Thr Arg Ser Val Arg Gly He Gln Asp Gly Val 85 90 95 He Phe Ser Met Gln Wing Ser Phe His Arg Gly Asp Glu He Glu • 100 105 110 His Met Asp Lys Met Arg Lys Val Pro Wing Pro Asp Glu He Lys Gly 115 120 125 Thr Val Glu Arg Met Pro He Ser Ser Arg Arg Val Leu Asp Glu Trp 130 135 140 Wing Glu Trp Asp He Arg Val He Pro Gln Asp Gln Leu Glu Leu Ser 145 150 155 160 Asp Phe Thr Ala Thr Glu Gln Wing Val Trp He Arg Cys Thr Wing Asp 165 170 175 Leu Pro Asp Asn Pro Thr Phe His Gln Cys Ser Leu Thr Tyr Leu Ser 180 185 190 10 Asp Met Thr Leu Leu His Ser Ala Leu Val Pro His Pro Gly Glu Lys 195 200 2 05 Met Gln Met Ala Ser Leu Asp His Wing Val Trp Phe Leu Arg Pro Phe 210 215 220 Arg Val Asp Glu Trp Leu Leu Tyr Asp Gln Arg Ser Pro Ser Wing Ser 225 230 235 240 Ser Gly Arg Ala Leu Thr His Gly Arg Leu Phe Asn Gln Gln Gly Asp 245 250 255 Leu Val Wing He Val Asn Gln Glu Gly Met Thr Arg Thr Leu His Glu 260 265 270 Gly Wing Gln Ser He Pro Met Arg Lys Asp 275 280 15 < 210 > 165 < 211 > 510 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (487) < 223 > RXN01421 < 400 > 165 20 ttgatgcacg tgcagaaatc gtcggcggtc cgtggcaccc atetgttaag ggagactegg 60 ttactgcagg gatcctgcga gatcgagtaa acgcctaaag atg acg tcg aaa age 115 Met Thr Ser Lys Ser 1 5 att age ggc aag cgc ccg aat ctg ccg tcg etc act gga gcg cgg tgg 163 He Ser Gly Lys Arg Pro Asn Leu Pro Ser Leu Thr Gly Wing Arg Trp 10 15 20 etc gcg gcg etc gct gtt tat ttt ttg cat gcg ttg gtg ttt ttg tcg 211 Leu Ala Wing Leu Wing Val Tyr Phe Leu His Wing Leu Val Phe Leu Ser 25 30 35 gtg tat ccg ttc cag cag tcg gaa ctg ttt gcc here ate cat aaa ttt 259 Val Tyr Pro Phe Gln Gln Ser Glu Leu Phe Ala Thr He His Lys Phe 25 40 45 50 .li.J ,, gtc ccc atg cag ctg ggt tea gct ggt gta acc ttc ttc ttt ate ttg 307 Val Pro Met Gln Leu Gly Ser Wing Gly Val Thr Phe Phe Phe He Leu 55 60 65 tcc gga ttt ttg ate tat tgg tea aat age cag etc aag ggc atg aag 355 Ser Gly Phe Leu He Tyr Trp Ser Asn Ser Gln Leu Lys Gly Met Lys 70 75 80 85 aat gtg ctg tat tac tgc aag cgc cgc ate acc aag att tat ccc atg 403 Asn Val Leu Tyr Tyr Cys Lys Arg Arg He Thr Lys He Tyr Pro Met 90 95 100 falls ttg att gcg ttg ccg atg ttt att gag gcg tcg gcg aag ttc acg 451 His Leu He Wing Wing Leu Pro Met Phe He Glu Wing Being Wing Lys Phe Thr 105 110 115 act ggc att ac tgg gtg ctg att ttg cgc gag taaagctgtg 497 Thr Thr Gly He Thr Trp Val Leu He Leu Arg Glu 120 125 gctgcggaat gcg 510 < 210 > 166 < 211 > 129 < 212 > PRT 10 < 213 > Corynebacterium glutamicum < 400 > 166 • Met Thr Ser Lys Ser Be Gly Lys Arg Pro Asn Leu Pro Ser Leu 1 5 10 15 Thr Gly Wing Arg Trp Leu Wing Wing Leu Wing Val Tyr Phe Leu His Wing 20 25 30 Leu Val Phe Leu Ser Val Tyr Pro Phe Gln Gln Ser Glu Leu Phe Wing 35 40 45 Thr He His Lys Phe Val Pro Met Gln Leu Gly Ser Wing Gly Val Thr 50 55 60 Phe Phe Phe He Leu Ser Gly Phe Leu He Tyr Trp Ser Asn Ser Gln 15 65 70 75 80 Leu Lys Gly Met Lys Asn Val Leu Tyr Tyr Cys Lys Arg Arg He Thr 85 90 95 Lys He Tyr Pro Met His Leu He Ala Leu Pro Met Phe He Glu Ala 100 105 110 Be Ala Lys Phe Thr Thr Thr Gly He Thr Trp Val Leu He Leu Arg 115 120 125 Glu • < 210 > 167 < 211 > 930 < 212 > DNA 20 < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (907) < 223 > RXN02342 < 400 > 167 caggttcgtg ctgcgtgcgg gtagttttta aaggtaaaac tttttgggcg tgtcgccctt 60 aaagcgcgct tttcgacgcg accccactac attggcttcc atg aac gtt gac att 115 Met Asn Val Asp He 1 5 25 tea cga tcc aga gag ccg cta aac gtt gag etc ctg aag gaa aaa ttg 163 Ser Arg Ser Arg Glu Pro Leu Asn Val Glu Leu Leu Lys Glu Lys Leu 10 15 20 etc caa aac ggt gac ttt ggc cag gtc att tac gaa aaa gtg here ggc 211 Leu Gln Asn Gly Asp Phe Gly Gln Val He Tyr Glu Lys Val Thr Gly 25 30 35 tcc act aat gct gac ttg ctg gca ctt gca ggt tet ggc gct cca aac 259 Be Thr Asn Wing Asp Leu Leu Wing Leu Wing Gly Ser Gly Wing Pro Asn 40 45 50 tgg acg gtg aaa act gtc gag ttt ca gt gat cat gcg cgt ggg cga etc 307 • Trp Thr Val Lys Thr Val Glu Phe Gln Asp His Wing Arg Gly Arg Leu 55 60 65 ggc cgc ccg tgg tet gcc ect gag ggt tcc caá aca ate gtg tet gtg 355 Gly Arg Pro Trp Be Wing Pro Glu Gly Ser Gln Thr He Val Ser Val 70 75 80 85 etc gtt cata tta att gat ca gtg gac cgg att ggc act att cca 403 Leu Val Gln Leu Ser He Asp Gln Val Asp Arg He Gly Thr He Pro 90 95 100 etc gcg gcg gga etc gct gtc atg gat gcg ttg aat gac etc ggt gtg 451 Leu Ala Ala Gly Leu Ala Val Met Asp Ala Leu Asn Asp Leu Gly Val 105 110 115 aac gat gtt caá ate cae ggc aag 499 10 gaa ggt gcc gga ctg aaa tgg ccc Glu Gly Wing Gly Leu Lys Trp Pro Asn Asp Val Gln He His Gly Lys 120 125 130 aaa etc tgc ggc ate ctg gtg gaa gcc acc ggc ttt gat tcc acc cca 547 Lys Leu Cys Gly He Leu Val Glu Ala Thr Gly Phe Asp Ser Thr Pro 135 140 145 here gtt gtc ate ggt tgg ggc act aat ate age ctg act aaa gag gag 595 Thr Val Val He Gly Trp Gly Thr Asn He Ser Leu Thr Lys Glu Glu 150 155 160 165 ctt ect gtt ect cat gca act tcc etc gca ttg gaa ggt gtt gaa gtc 643 Leu Pro Val Pro His Wing Thr Ser Leu Wing Leu Glu Gly Val Glu Val 170 175 180 15 gac aga acc ata ttc ctt att aat atg etc here cat ctg cat act cga 691 Asp Arg Thr Thr Phe Leu He Asn Met Leu Thr His Leu His Thr Arg 185 190 195 ctg gac cag tgg cag ggt cca agt gtg gat tgg etc gat gat tac cgt 739 Leu Asp Gln Trp Glr. Gly Pro Ser Val Asp Trp Leu Asp Asp Tyr Arg 200 205 210 gcg gta tgt tcc agt att ggc ca gt gtt cga gtg ctt cta ect ggg 787 Wing Val Cys Ser Be He Gly Gln Asp Val Arg Val Leu Leu Pro Gly 215 220 225 gat aaa gaa etc tta ggt gaa gcg ate ggt gtc gcg act ggc gga gaa 835 Asp Lys Glu Leu Leu Gly Glu Wing He Gly Val Wing Thr Gly Gly Glu 230 235 240 245 20 att cgt gtt cgc gat gct tcg ggc acc gtt drops acc etc aac gcc ggt 883 He Arg Val Arg Asp Wing Ser Gly Thr Val His Thr Leu Asn Wing Gly 250 255 260 gaa att acg falls ctt cgc ctg cag taaggtgacg gtatggggaa ttc 930 Glu He Thr His Leu Arg Leu Gln 265 < 210 > 168 < 211 > 269 < 212 > PRT < 213 > Corynebacterium gl .utamicum 25 < 400 > 168 iüiiiit r -rr "Met Asn Val Asp He Ser Arg Ser Arg Glu Pro Leu Asn Val Glu Leu 1 5 10 15 Leu Lys Glu Lys Leu Leu Gln Asn Gly Asp Phe Gly Gln Val He Tyr 20 25 30 Glu Lys Val Thr Gly Ser Thr Asn Wing Asp Leu Leu Wing Leu Wing Gly 35 40 45 Ser Gly Wing Pro Asn Trp Thr Val Lys Thr Val Glu Phe Gln Asp His 50 55 60 Wing Arg Gly Arg Leu Gly Arg Pro Trp Ser Wing Pro Glu Gly Ser Gln 65 70 75 80 Thr He Val Ser Val Leu Val Gln Leu Ser He Asp Gln Val Asp Arg 85 90 95 He Gly Thr He Pro Leu Wing Wing Gly Leu Wing Val Met Asp Wing Leu 100 105 110 Asn Asp Leu Gly Val Glu Gly Wing Gly Leu Lys Trp Pro Asn Asp Val 115 120 125 Gln He His Gly Lys Lys Leu Cys Gly He Leu Val Glu Wing Thr Gly 130 135 140 Phe Asp Ser Thr Pro Thr Val Val He Gly Trp Gly Thr Asn He Ser 145 150 155 160 Leu Thr Lys Glu Glu Leu Pro Val Pro His Wing Thr Ser Leu Wing Leu 165 170 175 Glu Gly Val Glu Val Asp Arg Thr Thr Phe Leu He Asn Met Leu Thr 180 185 190 His Leu His Thr Arg Leu Asp Gln Trp Gln Gly Pro Ser Val Asp Trp 195 200 205 Leu Asp Asp Tyr Arg Wing Val Cys Ser Ser He Gly Gln Asp Val Arg 210 215 220 Val Leu Leu Pro Gly Asp Lys Glu Leu Leu Gly Glu Wing He Gly Val 225 230 235 240 Wing Thr Gly Gly Glu He Arg Val Arg Asp Wing Ser Gly Thr Val His 245 250 255 Thr Leu Asn Wing Gly Glu He Thr His Leu Arg Leu Gln 260 265 < 210 > 169 < 211 > 2762 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (2739) < 223 > RXN00563 < 400 > 169 ttc tac aag gat etc tac gca cgt tcc gca cgc ggc acg gca gca ctg 48 Phe Tyr Lys Asp Leu Tyr Wing Arg Wing Wing Arg Gly Thr Wing Wing Leu 1 5 10 15 tgg ate gtg gcg gct aac ttg age tcc tac tea gac ate gac gcc ate 96 Trp He Val Wing Wing Asn Leu Ser Ser Tyr Ser Asp He Asp Ala He 20 25 30 ate aac tgg gtc gga tcc gag cag acc acc gtc aac ggc gca tcc 144 He Asn Trp Val Gly Ser Glu Gln Thr Thr Thr Val Asn Gly Wing Ser 35 40 45 aag ctg gtc aag cca gct ttg gtc ect acc ttg ctg ttc cca ttc gcg 192 Lys Leu Val Lys Pro Ala Leu Val Pro Thr Leu Leu Phe Pro Phe Ala gca ect cgc gtg tcc gga tcc atg gca gat gca ggc cca cag gca gaa 240 Ala Pro Arg Val Ser Gly Ser Met Ala Asp Ala Gly Pro Gln Ala Glu 65 70 75 80 tcc cag atg cga ctt ctg etc tgg tet gtt gag cgc etc ate gca ggt 288 Being Gln Met Arg Leu Leu Leu Trp Being Val Glu Arg Leu He Wing Gly 85 90 95 ctt gcg cca ttg ggc tcc tcc tc aac gtg ggt ccc falls ctg gtg 336 Leu Ala Pro Leu Gly Ser Ser He Asn Val Gly His Arg Leu His Val 100 105 110 gtc ate cca ggt tea cca aac cgt gga cgc ttc ggt ggc gat ggt gca 384 Val He Pro Gly Ser Pro Asn Arg Gly Arg Phe Gly Gly Asp Gly Wing 115 120 125 tac ggt gaa tcc aag gca gct etc gac gcc gtg gtt acc cgt tgg aac 432 Tyr Gly Glu Ser Lys Ala Ala Leu Asp Ala Val Val Thr Arg Trp Asn 130 135 140 gca gag ca gct gca tgg gga gca falls acc tcc etc gtg falls gct falls 480 Ala Glu Gln Ala Ala Trp Gly Ala His Thr Ser Leu Val His Ala His 145 150 155 160 ate ggt tgg gtt cgc ggc acc ggc etc atg ggc ggc aac gat ect ttg 528 He Gly Trp Val Arg Gly Thr Gly Leu Met Gly Gly Asn Asp Pro Leu 165 170 175 gtc aag gca gac gaa gca ggc gtg gaa acc tac tcc acc caa gaa 576 Val Lys Ala Ala Glu Glu Ala Gly Val Glu Thr Tyr Ser Thr Gln Glu 180 185 190 att gca gag aaa ctg ctg tcc cag gca act tcc act gtt cgc gag cag 624 He Wing Glu Lys Leu Leu Ser Gln Wing Thr Ser Thr Val Arg Glu Gln 195 200 205 gca gca tcc gcg cca ate acc gtc gac ttc act ggc gga ctt ggt gaa 672 Wing Wing Being Wing Pro He Thr Val Asp Phe Thr Gly Gly Leu Gly Glu 210 215 220 tet gat ctg aac ctg gcg gaa atg gca cgt gca gaa gca gct aag gca 720 Being Asp Leu Asn Leu Wing Glu Met Wing Arg Wing Glu Wing Wing Lys Wing 225 230 235 240 gct aac gca cca gtg gtt gag gct cca cgc here gtg gca gca ctg cca Wing Asn Wing Pro Val Val Glu Wing Pro Arg Thr Val Wing Wing Leu Pro 245 250 255 act ect tac cga ct gt g gt ca gt acc ac tct gt gt cat gt gt 816 Thr Pro Tyr Arg Pro Val Val Gln Thr Thr Pro Asp Phe Wing Gly Gln 260 265 270 gtc acc aac ctt gac gag atg gtc gtc ate gtt ggc gcc ggc gag 864 Val Thr Gln Asn Leu Asp Glu Met Val Val He Val Gly Ala Gly Glu 275 280 285 etc ggc cca ctg ggt tet gca cgt acg cgt tcc gac gcc gaa etc aac 912 Leu Gly Pro Leu Gly Be Wing Arg Thr Arg Phe Asp Wing Glu Leu Asn 290 295 300 ggt tcc etc tcc gcc gcg ggt gtc ate gaa ctt gca tgg acg atg gga 960 Gly Ser Leu Ser Ala Ala Gly Val He Glu Leu Ala Trp Thr Met Gly 305 310 315 320 ctt ate fall tgg gat gaa gat cca aag cca ggc tgg tac gac gac tcc 1008 Leu He His Trp Asp Glu Asp Pro Lys Pro Gly Trp Tyr Asp Asp Ser 325 330 335 gac gac gca gtg gcc gaa gaa gac ate tcc gac cgc tac cae gac gaa 1056 Asp Asp Ala Val Ala Glu Glu Asp He Phe Asp Arg Tyr His Asp Glu 340 345 350 gtc atg gca cgc gtt ggt gtc cgc aag tac aat gac atg ect gag tac 1104 Val Met Wing Arg Val Gly Val Arg Lys Tyr Asn Asp Met Pro Glu Tyr 355 360 365 ggc atg ate gac aac ttt gca cca gag ctg acc acc gtc tac etc gac 1152 Gly Met He Asp Asn Phe Wing Pro Glu Leu Thr Thr Val Tyr Leu Asp 370 375 380 cag gac etc acc ttc aac gtg gga tcc cgc gaa gag gca ctg acc tac 1200 Gln Asp Leu Thr Phe Asn Val Gly Ser Arg Glu Glu Ala Leu Thr Tyr 385 390 395 400 gtc gac tcc gag cca gaa etc acc ttt gct tet ttc gac gaa gca gca 1248 • 5 Val Asp Ser Glu Pro Glu Leu Thr Phe Wing Ser Phe Asp Glu Wing Wing 405 410 415 ggg gag tgg aag gtc act cgc aag gca ggc tcc gca ate cgc gta ect 1296 Gly Glu Trp Lys Val Thr Arg Lys Wing Gly Ser Wing He Arg Val Pro 420 425 430 cgc cgc atg gcg atg acc cgc ttc gtt ggt gga cag gtt ect aag gac 1344 Arg Arg Met Wing Met Thr Arg Phe Val Gly Gly Gln Val Pro Lys Asp 435 440 445 ttc gac cca gct gtg tgg ggc att cca gct gac atg gtg gac aac ctg 1392 Phe Asp Pro Wing Val Trp Gly He Pro Wing Asp Met Val Asp Asn Leu 450 455 460 gac acc gtc gcg ctg tgg aac att gtc tgt act gtc gac gcc ttc ctg 1440 JQ Asp Thr Val Wing Leu Trp Asn He Val Cys Thr Val Asp Wing Phe Leu 465 470 475 480 tcc gct gtc tc cca gca gag ctg ctt gct tcc gtt cae cca gca 1488 • Be Wing Gly Phe Thr Pro Wing Glu Leu Leu Wing Ser Val His Pro Wing 485 490 495 cgc gtg tcc tet acc g gc acc ggc atg ggc ggc atg gaa tcc etc 1536 Arg Val Ser Ser Thr Gln Gly Thr Gly Met Gly Gly Met Glu Ser Leu 500 505 510 cgt ggc ate tac gtc gac cgc att ctg gca gag cca cgc gcc aac gac 1584 Arg Gly He Tyr Val Asp Arg He Leu Wing Glu Pro Arg Wing Asn Asp 515 520 525 gtt ctg cag gaa gca ctg ccc aac gtt gtt gca gct gtc falls gtc atg cag 1632 15 Val Leu Gln Glu Wing Leu Pro Asn Val Val Wing Wing His Val Met Gln 530 535 540 tcc tac gtc ggt ggc tac gga cag atg ate drops cca gtc gca gct tgt 1680 Ser Tyr Val Gly Gly Tyr Gly Gln Met He His Pro Val Wing Wing Cys 545 550 555 560 gca acc gca gct gtt tet gtg gaa gaa gca ctg gac aag ate cgc ate 1728 Ala Thr Ala Ala Val Ser Val Glu Glu Ala Leu Asp Lys He Arg He 565 570 575 ggc aag tcc gac ttc gtt gtc gca ggt ggc ttc gat gcc ctg tcc gtt 1776 Gly Lys Ser Asp Phe Val Val Wing Gly Gly Phe Asp Wing Leu Ser Val 580 585 590 gaa ggc ate acc ggc ttc ggc gac a tg gca gca acc gcc gac tcc gca 1824 2Q Glu Gly He Thr Gly Phe Gly Asp Met Ala Ala Thr Ala Asp Ser Ala 595 600 605 gag atg gaa ggc aag gga att gag falls cgc ttc ttc tcc cgc gcc aac 1872 Glu Met Glu Gly Lys Gly He Glu His Arg Phe Phe Ser Arg Wing Asn 610 615 620 gac cgg cgc ggt ggt gga ttc ate gaa tc gaa ggt ggc gga acc gtc 1920 Asp Arg Arg Arg Gly Gly Phe He Glu Ser Glu Gly Gly Gly Thr Val 625 630 635 640 ctt ctg gca cgc gga tea etc gca gct gac ctg ggc ctt cca gta etc 1968 Leu Leu Wing Arg Gly Ser Leu Wing Wing Asp Leu Gly Leu Pro Val Leu 645 650 655 ggt gtc ate gga ttc gca gag tcc ttt gca gat ggt gcc falls acc tcc 2016 25 Gly Val He Gly Phe Wing Glu Ser Phe Wing Asp Gly Wing His Thr Ser 660 665 670 cca ccc gcc cca ggc etc ggt gcc ctt ggt gct gct cgc gat ggt gtg 2064 He Pro Wing Pro Gly Leu Gly Wing Leu Gly Wing Wing Arg Asp Gly Val 675 680 685 gaa tet cgc ctt gca gta gca ctg cgt tcc gtc ggt gtc tet gct gat 2112 Glu Ser Arg Leu Wing Val Wing Leu Arg Ser Val Gly Val Ser Wing Asp 690 695 700 gag ate tcc att ate tcc aag falls gac acc tcc acc aac gcg aat gat 2160 Glu He Ser He He Ser Lys His Asp Thr Ser Thr Asn Ala Asn Asp 705 710 715 720 cca aac gag tcc gac ctg cae gag cgc ate gca tcc gct ate ggt cgt 2208 Pro Asn Glu Be Asp Leu His Glu Arg He Wing Be Wing He Gly Arg 725 730 735 gca gac ggc aac ccg atg tac gtg att tcc cag aag tea etc acc gga 2256 Wing Asp Gly Asn Pro Met Tyr Val He Ser Gln Lys Ser Leu Thr Gly 740 745 750 falls gcc aag ggt ggt gca gca gca ttc cag atg ate ggt etc acc cag 2304 His Wing Lys Gly Wing Wing Wing Wing Phe Gln Met He Gly Leu Thr Gln 755 760 765 gtc etc cga tcc gga ctg gtg cca gcc aac cgc gca etc gac tgc gtt 2352 Val Leu Arg Ser Gly Leu Val Pro Wing Asn Arg Wing Leu Asp Cys Val 770 775 780 gac cca gta ctg tcc aag cat tcc falls etc gtc tgg ctg cgc aag cca 2400 Asp Pro Val Leu Ser Lys His Ser His Leu Val Trp Leu Arg Lys Pro 785 790 795 800 cta gac ctt cgt gcg aag gca cca aag gca ggt ctt gtt acc tcc ctt 2448 Leu Asp Leu Arg Wing Lys Wing Pro Lys Wing Gly Leu Val Thr Ser Leu 805 810 815 ggc ttc gga drops gtc tcc gct ctg gtt gcg att gtt drops cca gac gcc 2496 Gly Phe Gly His Val Ser Wing Leu Val Wing He Val His Pro Asp Wing 820 825 830 ttc tat gag gca gtt gtg cgt gca ggt ggt gg gg ga gc gac gta 2544 Phe Tyr Glu Wing Val Arg Val Ala. Arg Gly Wing Glu Wing Wing Asp Val 835 840 845 tgg cgc gca tcc gcg ate gct cgc gaa gaa gca ggc ctt cgt acc ate 2592 Trp Arg Ala Wing Wing Wing Arg i Glu Glu Wing Gly Leu Arg Thr He 850 855 860 gtc gcc ggt atg falls ggt ggc gta ctg tac gaa cgc cca gtc gag cgc 2640 Val Ala Gly Met His Gly Gly Val: Leu Tyr Glu Arg Pro Val Glu Arg 865 870 875 880 aac etc. ggt gtc falls gga gac gca, gct aag gaa gtt gaa gct gca gtc 2688 Asn Leu Gly Val His Gly Asp Ala j Ala Lys Glu Val Glu Ala Ala Val 885 890 895 etc ctg gat tcc cgc gcc cgc cta igtt gac ggt gtc etc cgc gcc gaa 2736 Leu Leu Asp Ser Arg Ala Arg Leu 'Val Asp Gly Val Leu Arg Ala Glu 900 905 910 ggc tagttggt: ta ttgcgttgag ccc 2762 Gly < 210 > 170 < 211 > 913 < 212 > PRT < 213 > Corynebact .eriu glutamicum < 400 > 170 Phe Tyr Lys Asp Leu Tyr Wing Arg Wing Wing Arg Gly Thr Wing Wing Leu 1 5 10 15 Trp He Val Wing Wing Asn Leu Being Ser Tyr Being Asp He Asp Wing He 20 25 30 He Asn Trp Val Gly Ser Glu Gln Thr Thr Thr Val Asn Gly Wing Ser 35 40 45 Lys Leu Val Lys Pro Wing Leu Val Pro Thr Leu Leu Phe Pro Phe Wing 50 55 60 Wing Pro Arg Val Ser Gly Ser Met Wing Asp Wing Gly Pro Gln Wing Glu 65 70 75 80 Being Gln Met Arg Leu Leu Leu Trp Being Val Glu Arg Leu He Wing Gly 85 90 95 Leu Ala Pro Leu Gly Be Ser He Asn Val Gly His Arg Leu His Val 100 105 110 Val He Pro Gly Ser Pro Asn Arg Gly Arg Phe Gly Gly Asp Gly Ala 115 120 125 Tyr Gly Glu Ser Lys Wing Wing Leu Asp Wing Val Val Thr Arg Trp Asn 130 135 140 Wing Glu Gln Wing Wing Trp Gly Wing His Thr Ser Leu Val His Wing His 145 150 155 160 He Gly Trp Val Arg Gly Thr Gly Leu Met Gly Gly Asn Asp Pro Leu 165 170 175 Val Lys Wing Wing Glu Glu Wing Gly Val Glu Thr Tyr Ser Thr Gln Glu 180 185 190 He Wing Glu Lys Leu Leu Ser Gln Wing Thr Ser Thr Val Arg Glu Gln 195 200 205 Wing Wing Wing Pro He Thr Val Asp Phe Thr Gly Gly Leu Gly Glu 210 215 220 Ser Asp Leu Asn Leu Wing Glu Met Wing Arg Wing Glu Wing Wing Lys Wing 225 230 235 240 Ala Asn Ala Pro Val Val Glu Ala Pro Arg Thr Val Ala Ala Leu Pro 245 250 255 Thr Pro Tyr Arg Pro Val Val Gln Thr Thr Pro Asp Phe Wing Gly Gln 260 265 270 Val Thr Gln Asn Leu Asp Glu Met Val Val He Val Gly Wing Gly Glu 275 280 285 Leu Gly Pro Leu Gly Ser Wing Arg Thr Arg Phe Asp Ala Glu Leu Asn 290 295 300 Gly Ser Leu Ser Ala Ala Gly Val He Glu Leu Ala Trp Thr Met Gly 305 310 315 320 Leu He His Trp Asp Glu Asp Pro Lys Pro Gly Trp Tyr Asp Asp Ser 325 330 335 Asp Asp Wing Val Wing Glu Glu Asp He Phe Asp Arg Tyr His Asp Glu 340 345 350 Val Met Wing Arg Val Gly Val Arg Lys Tyr Asn Asp Met Pro Glu Tyr 355 360 365 Gly Met He Asp Asn Phe Wing Pro Glu Leu Thr Thr Val Tyr Leu Asp 370 375 380 Gln Asp Leu Thr Phe Asn Val Gly Ser Arg Glu Glu Ala Leu Thr Tyr 385 390 395 400 Val Asp Ser Glu Pro Glu Leu Thr Phe Wing Ser Phe Asp Glu Wing Wing 405 410 415 Gly Glu Trp Lys Val Thr Arg Lys Wing Gly Ser Wing Arg Val Pro 420 425 430 Arg Arg Met Wing Met Thr Arg Phe Val Gly Gly Gln Val Pro Lys Asp 435 440 445 Phe Asp Pro Wing Val Trp Gly He Pro Wing Asp Met Val Asp Asn Leu 450 455 460 Asp Thr Val Aia Leu Trp Asn He Val Val Cys Thr Val Asp Ala Phe Leu 465 470 475 480 Ser Wing Gly Phe Thr Pro Wing Glu Leu Leu Wing Ser Val His Pro Wing 485 490 495 Arg Val Ser Ser Thr Gln Gly Thr Gly Met Gly Gly Met Glu Ser Leu 500 505 510 Arg Gly He Tyr Val Asp Arg He Leu Wing Glu Pro Arg Wing Asn Asp 515 520 525 Val Leu Gln Glu Wing Leu Pro Asn Val Val Wing Wing His Val Met Gln 530 535 540 Ser Tyr Val Gly Gly Tyr Gly Gln Met He His Pro Val Ala Ala Cys 545 550 555 560 Ala Thr Ala Ala Val Ser Val Glu Glu Ala Leu Asp Lys He Arg He 565 570 575 Gly Lys Ser Asp Phe Val Val Ala Gly Gly Phe Asp Wing Leu Ser Val 580 585 590 Glu Gly He Thr Gly Phe Gly Asp Met Wing Wing Thr Wing Asp Being Wing 595 600 605 Glu Met Glu Gly Lys Gly He Glu His Arg Phe Phe Ser Arg Wing Asn 610 615 620 Asp Arg Arg Arg Gly Gly Phe He Glu Ser Glu Gly Gly Gly Thr Val 625 630 635 640 Leu Leu Wing Arg Gly Ser Leu Wing Wing Asp Leu Gly Leu Pro Val Leu 645 650 655 Gly Val He Gly Phe Wing Glu Ser Phe Wing Asp Gly Wing His Thr Ser 660 665 670 He Pro Wing Pro Gly Leu Gly Wing Leu Gly Wing Wing Arg Asp Gly Val 675 680 685 Glu Ser Arg Leu Wing Val Wing Leu Arg Ser Val Gly Val Wing Wing Asp 690 695 700 Glu He Be He Be Ser Lys His Asp Thr Ser Thr Asn Wing Asn Asp 705 710 715 720 Pro Asn Glu Be Asp Leu His Glu Arg He Wing Be Wing He Gly Arg 725 730 735 Wing Asp Gly Asn Pro Met Tyr Val He Ser Gln Lys Ser Leu Thr Gly 740 745 750 His Wing Lys Gly Wing Wing Wing Wing Phe Gln Met He Gly Leu Thr Gln 755 760 765 Val Leu Arg Ser Gly Leu Val Pro Wing Asn Arg Wing Leu Asp Cys Val 770 775 780 Asp Pro Val Leu Ser Lys His Ser His Leu Val Trp Leu Arg Lys Pro 785 790 795 800 Leu Asp Leu Arg Ala Lys Ala Pro Lys Ala Gly Leu Val Thr Ser Leu 805 810 815 Gly Phe Gly His Val Ser Ala Leu Val Ala He Val His Pr or Asp Wing 820 825 830 Phe Tyr Glu Wing Val Arg Val Wing Arg Gly Wing Glu Wing Wing Asp Val 835 840 845 Trp Arg Wing Wing Wing Wing Wing Arg Glu Glu Wing Gly Leu Arg Thr He 850 855 860 Val Wing Gly Met His Gly Gly Val Leu Tyr Glu Arg Pro Val Glu Arg 865 870 875 880 Asn Leu Gly Val His Gly Asp Ala Ala Lys Glu Val Glu Ala Ala Val 885 890 895 Leu Leu Asp Ser Arg Ala Arg Leu Val Asp Gly Val Leu Arg Ala Glu 900 905 910 Gly i ~ m É s _ £ ^^^^^^ 210 > 171 < 211 > 2937 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (2914) < 223 > RXN02168 < 400 > 171 agggttt; agt < eatctatttc ggctaicgcti ac < gtaaiceta egeattegta ¡agtggtcatg 60 ggtccaagaa < gcccattcca agacttagga gcttta "ttte gtg agt att tet tea 115 Val Ser He Ser Ser 1 5 ctg here ccg ctg falls tet ttc aaa gag cca gca att ctg tac gcc ggt 163 Leu Thr Pro Leu His Ser Phe Lys Glu Pro Ala He Leu Tyr Ala Gly 10 15 20 cag gct tet gcc tgg cag cag gtg ate gct gat tcc age gaa gac cae 211 10 Gln Wing Be Wing Trp Gln Gln Val He Wing Asp Ser Ser Glu Asp His 25 30 35 ate acc gca acg falls ctg cgc gag etc ctg tet cgc tcc cgt gca aag 259 He Thr Ala Thr His Leu Arg Glu Leu Leu Ser Arg Ser Arg Ala Lys • 40 45 50 act gca ect ttc gct cgc ca g ect g gc cct cct cct tect cct 307 Thr Wing Pro Phe Wing Arg Gln He Thr Ala He Val Pro Gly Ser Leu 55 60 65 gct cgt ctt gag gaa ctg acc cgc gaa gac gca ca ate ggt gca gac 355 Wing Arg Leu Glu Glu Leu Thr Arg Glu Asp Wing Gln He Gly Wing Asp 70 75 80 85 ate gac gca cag ect gcc gt tcc att cca ggc att ctg gt gg cag 403 15 He Asp Ala Gln Pro Ala Val Ser He Pro Gly He Leu Leu Gly Gln 90 95 100 ate gct gca acc cgt cag ctg cgt gac etc gga etc gat gtc gca gca 451 He Wing Wing Thr Arg Gln Leu Arg Asp Leu Gly Leu Asp Val Ala Ala 105 110 115 gct tcc cgc ctt gga falls tcc cag ggc att ttg ggc gtt gaa gca gta 499 Wing Ser Arg Leu Gly His Ser Gln Gly He Leu Gly Val Glu Wing Val 120 125 130 gac aat gaa gaa gac gtt tta gct tcc gcc ate ctg ctg ggc gca gca 547 • Asp Asn Glu Glu Asp Val Leu Wing Phe Wing He Leu Leu Gly Wing Wing 135 140 145 gct tcc cag ttc gct ggc aag ggc gca cat atg etc tet gtt cgc ggc 595 20 Wing Being Gln Phe Wing Gly Lys Gly Wing His Met Leu Ser Val Arg Gly 150 155 160 165 ctg tcc cgt gag ate ate cag gac acc ate ggt gtc gat ggg gta 643 Leu Ser Arg Glu He He Gln Asp Thr He Ala Gly Val Asp Gly Val 170 175 180 gag gtc tcc ctg cgc aac gct cgt gca falls ttt gtt gtc tet ggt aag 691 Glu Val Ser Leu Arg Asn Ala Arg Ala His Phe Val Val Ser Gly Lys 185 190 195 cca gag gca ctg aag aag gct gct gct gta cgc cag cgc gca gct gat 739 Pro Glu Ala Leu Lys Lys Wing Wing Wing Ala Leu Gln Arg Wing Wing Asp 200 205 210 gtt tac aac gaa gac ate aac gaa aag cgc aag ggt gga tcc ctg gca 787 25 Val Tyr Asn Glu Asp He Asn Glu Lys Arg Lys Gly Gly Ser Leu Ala 215 220 225 gag ect aag ttt gac tac ttg gat gtg gcc att ect ttc cae cae tcc 835 Glu Pro Lys Phe Asp Tyr Leu Asp Val Wing Pro Phe His His Ser 230 235 240 245 tcc atg cag gac gca gcc gac ttg gct gtc gag tgg gca acc acc tgt Ser Met Gln Asp Wing Wing Asp Leu Wing Val Glu Trp Wing Thr Thr Cys 250 255 260 ggc cta aac gtc aac gcg cgc gcg ttg gca gaa gca att cta gtt aac 931 Gly Leu Asn Val Asn Ala Arg Ala Leu Ala Glu Ala • He Leu Val Asn 265 270 275 cca gct gac tgg gtt gag cag ate gca aac etc aag gct gat tac gtt 979 Pro Wing Asp Trp Val Glu Gln He Wing Asn Leu Lys Wing Asp Tyr Val 280 285 290 ctt tcc etc gca ggc gtc gtc cc ttc tc cc ttc gcc gac 1027 Leu Ser Leu Asp Wing Gly Val Ser Arg Phe Thr Wing Pro Leu Leu Asp 295 300 305 ggt cgc gga ate tet ttg gtt ect gcg ttc tcc gct gca gag cgc gac 1075 Gly Arg Gly Be Ser Leu Val Pro Wing Phe Be Wing Wing Glu Arg Asp 310 315 320 325 aac ttg gct cgc ect ggc ttc falls gtt ect acc gct gag gat tgg tcc 1123 10 Asn Leu Wing Arg Pro Gly Phe His Val Pro Thr Wing Glu Asp Trp Ser 330 335 340 gag ttc gct cca aag ctg gtt aag ctt cca aac ggt gag cae aag gtt 1171 Glu Phe Ala Pro Lys Leu Val Lys Leu Pro Asn Gly Glu His Lys Val 345 350 355 etc acc ggg ttc tcc cgc ctg act ggt tat tcc cca ate gtc ctg gct 1219 Leu Thr Gly Phe Ser Arg Leu Thr Gly Tyr Ser Pro He Val Leu Wing 360 365 370 ggc atg acc cca acc acc gtt gat ect gag ate gtt gca gct gca gcg 1267 Gly Met Thr Pro Thr Thr Val Asp Pro Glu He Val Wing Wing Wing Wing 375 380 385 aac gct gga drops tgg gcc gaa atg gcc ggt ggc gga cag tac tet gaa 1315 15 Asn Wing Gly His Trp Wing Glu Met Wing Gly Gly Gly Gln Tyr Ser Glu 390 395 400 405 gaa gtc ttc acc aag aac aag gaa aag etc gtt tcc ctg etc aag gtt 1363 Glu Val Phe Thr Lys Asn Lys Glu Lys Leu Val Ser Leu Leu Lys Val 410 415 420 gga cgc tcc gca cag ttc aac tcc atg ttc tcc gac cgc tac atg tgg 1411 Gly Arg Ser Wing Gln Phe Asn Ser Met Phe Phe Asp Arg Tyr Met Trp 425 430 435 aac ctg cag ttc ggt gca cag cgc ate gtt tcc aag gca cgt gca acc 1459 Asn Leu Gln Phe Gly Wing Gln Arg He Val Ser Lys Wing Arg Wing Thr 440 445 450 ggt acc tcc ate aac ggt gtt gtt gtc tcc gct ggt ate cca gag gtt 1507 20 Gly Thr Ser He Asn Gly Val Val Val Ser Wing Gly He Pro Glu Val 455 460 465 gag gaa gca act gag ctg ate aac gat ctg aac gct gat ggc tcc cca 1555 Glu Glu Wing Thr Glu Leu He Asn Asp Leu Asn Wing Asp Gly Phe Pro 470 475 480 485 tac gtt gca tcc aag cca ggc acc gtg gat cag tc cc gca acc ctg 1603 Tyr Val Wing Phe Lys Pro Gly Thr Val Asp Gln He Arg Wing Thr Leu 490 495 500 aag att gct gat gca aac cca gag acc aag ate ate ate ate gag 1651 Lys He Wing Asp Wing Asn Pro Glu Thr Lys He He He Gln He Glu 505 510 515 gac gga falls gct ggt ggc falls falls tcc tgg gtc aac ttg gac gat ctg 1699 25 Asp Gly His Wing Gly Gly His His Ser Trp Val Asn Leu Asp Asp Leu lAaj.A S & & & ^ £ * kw2. 520 525 530 etc ctg acc acc ac tac gca gag ctg cgt tcc cgc aag aac gtt gtc gtc 1747 Leu Leu Thr Thr Tyr Ala Glu Leu Arg Ser Arg Lys Asn Val Val Val 535 540 545 atg ate ggt ggc ggc ate gga acc ect gca aag gct gct tac tac ctg 1795 Met He Gly Gly Gly He Gly Thr Pro Ala Lys Ala Wing Tyr Tyr Leu 550 555 560 565 acc ggt gaa tgg tcg ac tgc gtc gtc cca gca gtc gac gcg gac 1843 Thr Gly Glu Trp Ser Thr Asp Leu Gly Phe Pro Wing Met Pro Val Asp • 570 575 580 ggc ate gtg etc gtg ggt acc gct gcc atg gca acc aag gaa gca acc act 1891 Gly He Leu Val Gly Thr Wing Wing Met Wing Thr Lys Glu Wing Thr Thr 585 590 595 tet ect cag gtc aag cag gca ctg gtc gac acc cca ggt gtt gat cca 1939 Ser Pro Gln Val Lys Gln Ala Leu Val Asp Thr Pro Gly Val Asp Pro 600 605 610 drops gac gct ggc ggc tgg gtt ggc cgt ggc gat gct cgt ggt ggc gtg 1987 His Asp Wing Gly Gly Trp Val Gly Arg Gly Asp Wing Arg Gly Gly Val 615 620 625 acc tet ggt ctg tea falls ctg drops gct gac atg tac gag ctg gac aac 2035 Thr Ser Gly Leu Ser u 10 His Le His Wing Asp Met Tyr Glu Leu Asp Asn 630 635 640 645 gat tet gct gca gct tcc cgc ctg ate tet tcc ate gat tet gat gat 2083 Asp Being Wing Wing Wing Being Arg Leu Being Ser Asp Asp Being Asp Asp • 650 655 660 tac gca gat drops cgc gag gag etc ate gag gct ate aac acag gct 2131 Tyr Ala Asp His Arg Glu Glu Leu He Glu Wing He Asn Lys Thr Wing 665 670 675 aag ect ttc ttc ggc gag gtc gaa gag atg act tac gca gag tgg ate 2179 Lys Pro Phe Phe Gly Glu Val Glu Glu Met Thr Tyr Ala Glu Trp He 680 685 690 cag cgt tgg gtt gag ctt gct tac cca act cag gac cca acc tgg gat 2227 15 Gln Arg Trp Val Glu Leu Wing Tyr Pro Thr Gln Asp Pro Thr Trp Asp 695 700 705 gat cgt ttc etc. gat ttg gtt drops cgc att gaa gct cgt etc aac gag 2275 Asp Arg Phe Leu Asp Leu Val His Arg He Glu Wing Arg Leu Asn Glu 710 715 720 725 gca gag drops ggc gcc tc cc tc cc gcg tet gtg 2323 Val cag 2371 Gln 745 750 755 gcc cgc gag ate cag gtc tet gcg cgc gac gcc gcg tgg ttt att ggt 2419 20 Wing Arg Glu He Gln Val Wing Wing Arg Asp Wing Wing Trp Phe He Gly 760 765 770 ctg tgc cgc aag falls falls act ect atg ect tgg gtt cca gca ate gat 2467 Leu Cys Arg Lys His His Lys Pro Met Pro Trp Val Pro Wing He Asp 775 780 785 gct gac cta gca cgc tgg tgg ggg ctt gac acc ctg tgg cag tcc cag 2515 Wing Asp Leu Wing Arg Trp Trp Gly Leu Asp Thr Leu Trp Gln Ser Gln 790 795 800 805 aac gag cgc tac ggc gcg aac tea gtc cgc gtt ate cca gga cca gtc 2563 Asn Glu Arg Tyr Gly Wing Asn Ser Val Arg Val He Pro Gly Pro Val 810 815 820cc gtc gcc gcc ate gac cgt gtt gac gac cca gtt gca gag ctg etc 2611 25 Ser Val Ala Gly He Asp Arg Val Asp Glu Pro Val Ala Glu Leu Leu ^ MJMaa? É ^ 825 830 835 ggc cgc ttc gaa gct gcc tgc gtt gac gct etc gac ggc gag cca gaa 2659 Gly Arg Phe Glu Wing Wing Cys Val Asp Ala Leu Asp Gly Glu Pro Glu 840 845 850 gag ate ttc gct cgc etc aat gag tcc aag aac gag cgc gaa ttc ctg 2707 Glu He Phe Wing Arg Leu Asn Glu Ser Lys Asn Glu Arg Glu Phe Leu 855 860 865 ctg gct acc cca falls ate gtg tgg falls ggc aac ctg ate gac aac cca 2755 Leu Ala Thr Pro His He Val Trp His Gly Asn Leu He Asp Asn Pro 870 875 880 885 gct drop gtc etc aac gag ggt gct gtc gag etc ate gag gag gat ggc 2803 Wing His Val Leu Asn Glu Gly Wing Phe Glu Leu He Glu Glu Asp Gly 890 895 900 tac tgg gtc ate cgt ate ctg gct gat tcc tac tc c gac gat ctg cca 2851 Tyr Trp Val He Arg He Leu Wing Asp Ser Tyr Phe Asp Asp Leu Pro 905 910 915 gtt gag cag cgc cca tac ctg gtt cag cat gtt gac ate cca gtt gag 2899 Val Glu Gln Arg Pro Tyr Leu Val Gln His Val Asp He Pro Val Glu 920 925 930 ctg ggt gac gct ggt tgaaccggtg gtttcccaat tgg 2937 10 Leu Gly Asp Ala Gly 935 < 210 > 172 • < 211 > 938 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 172 Val Ser He Ser Ser Leu Thr Pro Leu His Ser Phe Lys Glu Pro Wing 1 5 10 15 He Leu Tyr Wing Gly Gln Wing Being Wing Trp Gln Gln Val He Wing Asp 15 20 25 30 Being Ser Glu Asp His He Thr Wing Thr His Leu Arg Glu Leu Leu Ser 35 40 45 Arg Ser Arg Ala Lys Thr Ala Pro Phe Ala Arg Gln He Thr Ala He 50 55 60 Val Pro Gly Ser Leu Ala Arg Leu Glu Glu Leu Thr Arg Glu Asp Ala 65 70 75 80 Gln He Gly Wing Asp He Asp Wing Gln Pro Wing Val Ser He Pro Gly 85 90 95 • He Leu Leu Gly Gln He Wing Wing Thr Arg Gln Leu Arg Asp Leu Gly 100 105 110 Leu Asp Val Wing Wing Wing Being Arg Leu Gly His Ser Gln Gly He Leu 20 115 120 125 Gly Val Glu Ala Val Asp Asn Glu Aslu Val Leu Ala Phe Ala He 130 135 140 Leu Leu Gly Ala Ala Ala Ser Gln Phe Ala Gly Lys Gly Ala His Met 145 150 155 160 Leu Ser Val Arg Gly Leu Ser Arg Glu He He Gln Asp Thr He Wing 165 170 175 Gly Val Asp Gly Val Glu Val Ser Leu Arg Asn Ala Arg Ala His Phe 180 185 190 Val Val Ser Gly Lys Pro Glu Ala Leu Lys Lys Ala Ala Ala Wing Leu 195 200 20 5 Gln Arg Ala Ala Asp Val Tyr Asn Glu Asp He Asn Glu Lys Arg Lys 25 210 215 220 Gly Gly Ser Leu Wing Glu Pro Lys Phe Asp Tyr Leu Asp Val Wing He 225 230 235 240 Pro Phe His His Ser Ser Met Gln Asp Ala Ala Asp Leu Ala Val Glu 245 250 255 Trp Wing Thr Thr Cys Gly Leu Asn Val Asn Wing Arg Wing Leu Wing Glu 260 265 270 Wing He Leu Val Asn Pro Wing Asp Trp Val Glu Gln He Wing Asn Leu 275 280 285 Lys Wing Asp Tyr Val Leu Ser Leu Asp Wing Gly Val Being Arg Phe Thr 290 295 300 Wing Pro Leu Leu Asp Gly Arg Gly He Ser Leu Val Pro Wing Phe Ser 305 310 315 320 Ala Ala Glu Arg Asp Asn Leu Ala Arg Pro Gly Phe His Val Pro Thr 325 330 335 Wing Glu Asp Trp Ser Glu Phe Wing Pro Lys Leu Val Lys Leu Pro Asn 340 345 350 Gly Glu His Lys Val Leu Thr Gly Phe Ser Arg Leu Thr Gly Tyr Ser 355 360 365 Pro He Val Leu Wing Gly Met Thr Pro Thr Thr Val Asp Pro Glu He 370 375 380 Val Wing Wing Wing Wing Asn Wing Gly His Trp Wing Glu Met Wing Gly Gly 385 390 395 400 Gly Gln Tyr Ser Glu Glu Val Phe Thr Lys Asn Lys Glu Lys Leu Val 405 410 415 Being Leu Leu Lys Val Gly Arg Being Wing Gln Phe Asn Being Met Phe Phe 420 425 430 Asp Arg Tyr Met Trp Asn Leu Gln Phe Gly Wing Gln Arg He Val Ser 435 440 445 Lys Wing Arg Wing Thr Gly Thr Ser He Asn Gly Val Val Val Wing Wing 450 455 460 Gly He Pro Glu Val Glu Glu Wing Thr Glu Leu He Asn Asp Leu Asn 465 470 475 480 Wing Asp Gly Phe Pro Tyr Val Wing Phe Lys Pro Gly Thr Val Asp Gln 485 490 495 He Arg Wing Thr Leu Lys He Wing Asp Wing Asn Pro Glu Thr Lys He 500 505 510 He He Gln He Glu Asp Gly His Wing Gly Gly His His Ser Trp Val 515 520 525 Asn Leu Asp Lep Leu Leu Thr Thr Tyr Ala Glu Leu Arg Ser Arg 530 535 540 Lys Asn Val Val Val Met He Gly Gly Gly He Gly Thr Pro Ala Lys 545 550 555 560 Wing Wing Tyr Tyr Leu Thr Gly Glu Trp Ser Thr Asp Leu Gly Phe Pro 565 570 575 Wing Met Pro Val Asp Gly He Leu Val Gly Thr Wing Wing Met Wing Thr 580 585 590 Lys Glu Wing Thr Thr Ser Pro Gln Val Lys Gln Wing Leu Val Asp Thr 595 600 605 Pro Gly Val Asp Pro His Asp Wing Gly Gly Trp Val Gly Arg Gly Asp 610 615 620 Wing Arg Gly Gly Val Thr Ser Gly Leu Ser His Leu His Wing Asp Met 625 630 635 640 Tyr Glu Leu Asp Asn Asp Ser Ala Ala Ala Ser Arg Leu He Ser Ser 645 650 655 He Asp As Asp Asp Tyr Wing Asp His Arg Glu Glu Leu He Glu Wing 660 665 670 He Asn Lys Thr Wing Lys Pro Phe Phe Gly Glu Val Glu Glu Met Thr 675 680 685 Tyr Wing Glu Trp He Gln Arg Trp Val Glu Leu Wing Tyr Pro Thr Gln 690 695 700 Asp Pro Thr Trp Asp Asp Arg Phe Leu Asp Leu Val His Arg He Glu 705 710 715 720 Wing Arg Leu Asn Glu Wing Glu His Gly Wing He Thr Thr Leu Phe Pro 725 730 735 Asp His Wing Ser Val Glu Asn Glu Glu Glu Wing Val Glu Lys Leu Leu 740 745 750 Wing Wing Tyr Pro Gln Wing Arg Glu He Gln Val Wing Wing Arg Asp Wing 755 760 765 Wing Trp Phe He Gly Leu Cys Arg Lys His His Lys Pro Met Pro Trp 770 775 780 Val Pro Wing Asp Wing Asp Leu Wing Arg Trp Trp Gly Leu Asp Thr 785 790 795 800 Leu Trp Gln Ser Gln Asn Glu Arg Tyr Gly Wing Asn Ser Val Arg Val 805 810 815 He Pro Gly Pro Val Ser Val Wing Gly He Asp Arg Val Asp Glu Pro 820 825 830 Val Wing Glu Leu Leu Gly Arg Phe Glu Wing Wing Cys Val Asp Wing Leu 10 835 840 845 Asp Gly Glu Pro Glu Glu He Phe Wing Arg Leu Asn Glu Ser Lys Asn 8 50 855 860 Glu Arg Glu Phe Leu Leu Wing Thr Pro His He Val Trp His Gly Asn • 865 870 875 880 Leu He Asp Asn Pro Wing His Val Leu Asn Glu Gly Wing Phe Glu Leu 885 890 895 He Glu Glu Asp Gly Tyr Trp Val He Arg He Leu Wing Asp Ser Tyr 900 905 910 Phe Asp Asp Leu Pro Val Glu Gln Arg Pro Tyr Leu Val Gln His Val 915 920 925 Asp He Pro Val Glu Leu Gly Asp Ala Gly 15 930 935 < 210 > 173 < 211 > 921 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS • < 222 > (101) .. (898) < 223 > RXN01090 20 < 400 > 173 gccggtttgg gctggttgga gctctagatc gtaagtggtg tcgtacccat gacgtaccat 60 taaccacgaa cgttttaaag aagccacgaa ggagcctgac atg gcg tta cca cta 115 Met Ala Leu Pro Leu 1 5 ccc age aag age gct cga gca ctt gtt act ggg gca age ca ggc att 163 Pro Ser Lys Ser Ala Arg Ala Leu Val Thr Gly Ala Ser Gln Gly He 10 15 20 ggc etc gcc ate gcc aaa gat ttg gcg cgg tat ggg falls aac etc att 211 Gly Leu Wing He Wing Lys Asp Leu Wing Arg Tyr Gly His Asn Leu He 25 30 35 ttg gtt gct cgc cgc gag gat gtc etc aaa gag ate gcc gca gat cta 259 25 Leu Val Ala Arg Arg Glu Asp Val Leu Lys Glu He Ala Wing Asp Leu 40 45 50 gag aag aag drops ggc gtg ate gtt gag gtc cgc cgg gtg gat ttg agt 307 Glu Lys Lys His Gly Val He Val Glu Val Arg Pro Val Asp Leu Ser 55 60 65 gat gag cca gcc cgc aag gtg ttg ate gat gag ate aag aga agg gaa 355 Asp Glu Pro Wing Arg Lys Val Leu 'He Asp Glu He Lys Thr Arg Glu 70 75 80 85 ate aac ate ate att aac tet gct ggc ate gca age ttt ggg ccg ttc 403 • He Asn He He Has Asn Being Wing Gly He Wing Being Phe Gly Pro Phe 90 95 100 aag gac cag gat tgg tet tat gag act gcc cag ttc tea ctt aat gcc 451 Lys Asp Gln Asp Trp Ser Tyr Glu Thr Wing Gln Phe Ser Leu Asn Ala 105 110 115 here gcc gtt ttt gag etc acc fall gcg gtg gt ggt ggc atg att gac 499 Thr Wing Val Phe Glu Leu Thr His Wing Val Leu Gly Gly Met He Asp 120 125 130 cgt ggc acg ggc gct att tgc aat gtg gga tgc gg ggg aat gtg 547 Arg Gly Thr Gly Wing He Cys Asn Val Gly Ser Wing Wing Gly Asn Val 135 140 145 cca ccc cc aac aac aac gcc acg tat gtg etc acc aag gct gcg gc aac 595 10 Pro He Pro Asn Asn Wing Thr Tyr Val Leu Thr Lys Wing Gly Val Asn 150 155 160 165 gcg ttc acc gag gca atg cat tat gag ctg cgc gga act ggt gtg gcg 643 • Wing Phe Thr Glu Wing Met His Tyr Glu Leu Arg Gly Thr Gly Val Wing 170 175 180 tgt act ttg etc gca ccg gga ect gtc cgt gag gcg gag ate ect gag 691 Cys Thr Leu Leu Wing Pro Gly Pro Val Arg Glu Ala Glu He Pro Glu 185 190 195 tet gag aag tcg ate gtg gac aag gtt gtc ect gat ttc ttg tgg tgg 739 Ser Glu Lys Ser He Val Asp Lys Val Val Pro Asp Phe Leu Trp Thr 200 205 210 acc tat gag tcc tgc tcc gca gag acc ttg cgt gcg ctg tet aag aat 787 15 Thr Tyr Glu Ser Cys Ser Wing Glu Thr Leu Arg Wing Leu Ser Lys Asn 215 220 225 cag cgc gtt gtt cca ggt ccg ctg tcc aag gcc atg aat ttt gtg 835 Gln Arg Arg Val Val Pro Gly Pro Leu Ser Lys Ala Met Asn Phe Val 230 235 240 245 tcc tet gtt cct ac gct gct gctc etc tcc ect gtt atg ggc tgg gtt 883 Ser Ser Val Wing Pro Thr Wing Val Leu Ser Pro Val Met Gly Trp Val 250 255 260 ^ P tat aag aag atg ggt tagttttt -3B clagtgtctga at: c 921 Tyr Lys Lys Met Gly 265 20 < 210 > 174 < 211 > 266 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 174 Met Ala Leu Pro Leu Pro Ser Lys Ser Ala Arg Ala Leu Val Thr Gly 1 5 10 15 Wing Being Gln Gly He Gly Leu Wing He Wing Lys Asp Leu Wing Arg Tyr 20 25 30 Gly His Asn Leu He Leu Val Wing Arg Arg Glu Asp Val Leu Lys Glu 35 40 45 25 He Wing Wing Asp Leu Glu Lys Lys His Gly Val He Val Val Val Arg 50 55 Pro Val Asp Leu Ser Asp Glu Pro Ala Arg Lys Val Leu He Asp Glu 65 70 75 80 He Lys Thr Arg Glu He Asn He He He Asn Being Wing Gly He Wing 85 90 95 Being Phe Gly Pro Phe Lys Asp Gln Asp Trp Ser Tyr Glu Thr Wing Gln 100 105 110 Phe Ser Leu Asn Wing Thr Wing Val Phe Glu Leu Thr His Wing Val Leu 115 120 125 • Gly Gly Met He Asp Arg Gly Thr Gly Wing He Cys Asn Val Gly Ser 130 135 140 Wing Wing Gly Asn Val Pro Pro Asn Asn Wing Thr Tyr Val Leu Thr 145 150 155 160 Lys Wing Gly Val Asn Wing Phe Thr Glu Wing Met His Tyr Glu Leu Arg 165 170 175 Gly Thr Gly Val Wing Cys Thr Leu Leu Wing Pro Gly Pro Val Arg Glu 180 185 190 Wing Glu He Pro Glu Ser Glu Lys Ser He Val Asp Lys Val Val Pro 195 200 205 Asp Phe Leu Trp Thr Thr Tyr Glu Ser Cys Ser Wing Glu Thr Leu Arg 10 210 215 220 Wing Leu Ser Lys Asn Gln Arg Arg Val Val Pro Gly Pro Leu Ser Lys 225 230 235 240 Wing Met Asn Phe Val Ser Ser Val Wing Pro Thr Ala Val Leu Ser Pro • 245 250 255 Val Met Gly Trp Val Tyr Lys Lys Met Gly 260 265 < 210 > 175 < 211 > 1293 < 212 > DNA < 213 > Corynebacterium glutamicum 15 < 220 > < 221 > CDS < 222 > (101) .. (1270) < 223 > RXN02062 < 400 > 175 ttgtctaaac atcgttttgg ggtccgaatg atagcccctt ttaatgcccc cattteggta 60 • tcgctgcgca actgttttta gatggctaat ctttgaaatt atg aga gtc gga atg 115 Met Arg Val Gly Met 1 5 atg here aga gag tat cca cca gag gtt tac ggc ggc gct ggc gtg falls 163 20 Met Thr Arg Glu Tyr Pro Pro Glu Val Tyr Gly Gly Wing Gly Val His 10 15 20 gtc acc gaa ttg acc cga ttc atg cgt gag ate gct gaa gtt gat gtt 211 Val Thr Glu Leu Thr Arg Phe Met Arg Glu He Ala Glu Val Asp Val 25 30 35 falls tgc atg ggt gca ect cgc gat atg gag gga gtt ttc gtc falls ggc 259 His Cys Met Gly Ala Pro Arg Asp Met Glu Gly Val Phe Val His Gly 40 45 50 gtc gat ect gcc ttg gaa age gcg aac ect gcg att aag here ctg tcc 307 Val Asp Pro Ala Leu Glu Be Ala Asn Pro Ala He Lys Thr Leu Ser 55 60 65 acc ggt tta cgc atg gca gaa gct gca aac aac gtg gat gtc gtg falls 355 25 Thr Gly Leu Arg Met Wing Glu Wing Wing Asn Asn Val Asp Val Val His 70 75 80 85 tea falls act tgg tat gca ggt ctt ggc ggc falls ctt gca gct cgt etc 403 Ser His Thr Trp Tyr Wing Gly Leu Gly Gly His Leu Ala Ala Arg Leu 90 95 100 falls ggc att ect falls gtg gct acc gcg falls tet ttg gag cca gat cgc 451 His Gly He Pro His Val Wing Thr Wing His Ser Leu Glu Pro Asp Arg 105 110 115 cca tgg aag cgt gag cag ctt ggc ggt gga tac gac gtg tcc tcc tgg 499 Pro Trp Lys Arg Glu Gln Leu Gly Gly Gly Tyr Asp Val Ser Ser Trp 120 125 130 tet gaa aaa aat gcc atg gaa tac gct gac gcg gtc ate gct gtg tcg 547 Ser Glu Lys Asn Wing Met Glu Tyr Wing Asp Wing Val He Wing Val Ser 135 140 145 gct cgc atg aaa gat tcc ate gct gcg tac ect cgc ate gag ccg 595 Arg Met Lys Asp Ser He Leu Wing Wing Tyr Pro Arg He Glu Pro 150 155 160 165 gac aac gtg cgt gtt gtc etc aac ggc ate gac act gag ttg tgg cag 643 Asp Asn Val Val Val Leu Asn Gly He Asp Thr Glu Leu Trp Gln 170 175 180 ect cgc ccg act ttc gat gac gcg gaa gat tcc gta etc cgc tcc cta 691 Pro Arg 10 Pro Thr Phe Asp Asp Ala Glu Asp Ser Val Leu Arg Ser Leu 185 190 195 ggc gtt gac cca cag cgg ccc ate gtc gca ttt gtc ggc cgc ate acc 739 • Gly Val Asp Pro Gln Arg Pro He Val Wing Phe Val Gly Arg He Thr 200 205 210 cgc caa aaa ggc gtc gag drops etc ate aag gca gcg ctt ttc gac 787 Arg Gln Lys Gly Val Glu His Leu He Lys Ala Ala Ala Leu Phe Asp 215 220 225 gag tcc gtg cag ctt gtg etc tgt gcc gcg gcg cca gac acc ccc gaa 835 Glu Ser Val Gln Leu Val Leu Cys Ala Gly Ala Pro Asp Thr Pro Glu 230 235 240 245 ate gca gct cgc acc acc gcc ctg gtg gaa gaa etc cag gca aag cgc 883 15 Wing Wing Arg Thr Thr Wing Leu Val Glu Glu Leu Gln Wing Lys Arg 250 255 260 gaa ggc att ttc tgg gtt cag gac atg ctg ggc aag gac aaa ate caa 931 Glu Gly He Phe Trp Val Gln Asp Met Leu Gly Lys Asp Lys He Gln 265 270 275 gag att etc acc gct gac acc ttc gtg tgc cca tcc att tac gag 979 Glu He Leu Thr Wing Wing Asp Thr Phe Val Cys Pro Ser He Tyr Glu 280 285 290 cca ctg ggc ate gtg aac ttg gaa gca atg gcc tgc aac ac gca gtt 1027 Pro Leu Gly He Val Asn Leu Glu Wing Met Wing Cys Asn Thr Wing Val 295 300 305 gtc gca tcc gac gtt gga ggc ate ect gag gtt gtt gtc gac ggc acc 1075 20 Val Ala Ser Asp Val Gly Gly He Pro Glu Val Val Val Asp Gly Thr 310 315 320 325 acc ggc gcc etc gtt falls tac gac gaat aat gat gtc gaa acc ttc gag 1123 Thr Gly Ala Leu Val His Tyr Asp Glu Asn Asp Val Glu Thr Phe Glu 330 335 340 cgc gat ate gcc gaa gcg gtg aat aaa atg gtc gct gat cga gag acc 1171 Arg Asp He Wing Glu Wing Val Asn Lys Met Val Wing Asp Arg Glu Thr 345 350 355 gca gcc aaa ttt ggt etc gca ggg cgc gaa cgt gct ate aat gat ttc 1219 Wing Wing Lys Phe Gly Leu Wing Gly Arg Glu Arg Wing He Asn Asp Phe 360 365 370 tcc tgg gca acg att gct cag cag acc att gat gtg tac aaa tcc ttg 1267 25 Ser Trp Wing Thr He Wing Gln Gln Thr He Asp Val Tyr Lys Ser Leu 375 380 385 atg taaaaccgaa agccggggaa ect 1293 Met 390 < 210 > 176 < 211 > 390 < 212 > PRT • < 213 > Corynebacterium glutamicum < 400 > 176 Met Arg Val Gly Met Met Thr Arg Glu Tyr Pro Pro Glu Val Tyr Gly 1 5 10 15 Gly Wing Gly Val His Val Thr Glu Leu Thr Arg Phe Met Arg Glu He 20 25 30 Wing Glu Val Asp Val His Cys Met Gly Ala Pro Arg Asp Met Glu Gly 35 40 45 Val Phe Val His Gly Val Asp Pro Ala Leu Glu Be Ala Asn Pro Wing 50 55 60 He Lys Thr Leu Ser Thr Gly Leu Arg Met Wing Glu Wing Ala Asn Asn 65 70 75 80 10 Val Asp Val Val His Ser His Thr Trp Tyr Wing Gly Leu Gly Gly His 85 90 95 • Leu Wing Wing Arg Leu His Gly He Pro His Val Wing Thr Wing His Ser 100 105 110 Leu Glu Pro Asp Arg Pro Trp Lys Arg Glu Gln Leu Gly Gly Gly Tyr 115 120 125 Asp Val Ser Ser Trp Ser Glu Lys Asn Wing Met Glu Tyr Wing Asp Wing 130 135 140 Val He Wing Val Wing Wing Arg Met Lys Asp Ser He Leu Wing Wing Tyr 145 150 155 160 Pro Arg He Glu Pro Asp Asn Val Val Val Leu Asn Gly He Asp 165 170 175 15 Thr Glu Leu Trp Gln Pro Arg Pro Thr Phe Asp Asp Wing Glu Asp Ser 180 185 190 Val Leu Arg Ser Leu Gly Val Asp Pro Gln Arg Pro He Val Wing Phe 195 200 205 Val Gly Arg He Thr Arg Gln Lys Gly Val Glu His Leu He Lys Wing 210 215 220 Wing Ala Leu Phe Asp Glu Ser Val Gln Leu Val Leu Cys Ala Gly Ala • 225 230 235 240 Pro Asp Thr Pro Glu He Ala Wing Arg Thr Thr Wing Leu Val Glu Glu 245 250 255 Leu Gln Wing Lys Arg Glu Gly He Phe Trp Val Gln Asp Met Leu Gly 260 265 270 20 Lys Asp Lys He Gln Glu He Leu Thr Wing Wing Asp Thr Phe Val Cys 275 280 285 Pro Ser He Tyr Glu Pro Leu Gly He Val Asn Leu Glu Ala Wing Wing 290 295 300 Cys Asn Thr Wing Val Val Wing As As Val Gly Gly He Pro Glu Val 305 310 315 320 Val Val Asp Gly Thr Thr Gly Ala Leu Val His Tyr Asp Glu Asn Asp 325 330 335 Val Glu Thr Phe Glu Arg Asp He Wing Glu Wing Val Asn Lys Met Val 340 345 350 Wing Asp Arg Glu Thr Wing Wing Lys Phe Gly Leu Wing Gly Arg Glu Arg 355 360 365 25 ^ g ^^ ¿¿&^ _ ^ ^ ^ ^ i-fcA Ala He Asn Asp Phe Ser Trp Wing Thr He Wing Gln Gln Thr He Asp 370 375 380 Val Tyr Lys Ser Leu Met 385 390 < 210 > 177 < 211 > 1266 < 212 > DNA • < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1243) < 223 > RXN02148 < 400 > 177 gcctcagact acggaatccc tgtgeaggtg gtatetgttg attcagcacc gttttatggt 60 gcgcgtcgct actaagaaat agttcgtcag gagaatettt gtg tet gca tcc cga 115 Val Ser Ala Ser Arg 1 5 10 aaa act etc gtt gtg acc aat gat ttt ect cca cgg ate ggc gga ate 163 Lys Thr Leu Val Val Thr Asn Asp Phe Pro Pro Arg He Gly Gly He 10 15 20 • caa age tat ttg agg gat ttc ate gct act ca a gat ect gag tcg ate 211 Gln Ser Tyr Leu Arg Asp Phe He Wing Thr Gln Asp Pro Glu Ser He 25 30 35 gtg gtg ttt gcg tcg act caac aac gct gag gac gcg cat gcc tac gac 259 Val Val Phe Wing Ser Thr Gln Asn Wing Glu Glu Wing His Wing Tyr Asp 40 45 50 aag act ttg gac tat gag gtc att agg tgg ect cgt tcg gtg atg ctg 307 Lys Thr Leu Asp Tyr Glu Val He Arg Trp Pro Arg Ser Val Met Leu 55 60 65 15 ccc acc acca acca gca cae gct atg gcg gag ate att cgt gag cga 355 Pro Thr Pro Thr Thr Ala His Ala Met Ala Glu He He Arg Glu Arg 70 75 80 85 gag ate gat aat gtg tgg tcg ggt gcg gcg gct ccg tcg gcg ttg atg 403 Glu He Asp Asn Val Trp Phe Gly Wing Wing Pro Pro L eu Ala Leu Met 90 95 100 gca ggc here gcg aag cag gca ggt gcg age aag gtt att gcc tcc act 451 Wing Gly Thr Wing Lys Gln Wing Gly Ala Ser Lys Val He Wing Being Thr 105 110 115 cat ggg cat gag gtg ggg tgg tea atg ctt ect gga tcg aga cac tcg 499 His Gly His Glu Val Gly Trp Ser Met Leu Pro Gly Ser Arg Gln Ser 120 125 130 20 ttg cgc aaa ate ggc act gag gtg gac gtg ctg act tat ate tcg cag 547 Leu Arg Lys He Gly Thr Glu Val Asp Val Leu Thr Tyr He Ser Gln 135 140 145 tac acg ctg cgc aga ttc aaa agt gct ttt gga tcg falls ccg act ttt 595 Tyr Thr Leu Arg Arg Phe Lys Ser Wing Phe Gly Ser His Pro Thr Phe 150 155 160 165 gaa cat ttg ect tc ggc gtg gac gtt aag aga aga tcc act ccg gcc acg 643 Glu His Leu Pro Ser Gly Val Asp Val Lys Arg Phe Thr Pro Wing Thr 170 175 180 cca gag gac aaa age gca ac agg aaa aag cta gga ttc acg gac acc 691 Pro Glu Asp Lys Ser Wing Thr Arg Lys Lys Leu Gly Phe Thr Asp Thr 185 190 195 25 acc ccg gtt att gcc tgt aac tcg cgt tta gtg ccg agg aaa ggc cag 739 Thr Pro Val He Wing Cys Asn Ser Arg Leu Val Pro Arg Lys Gly Gln 200 205 210 gac tcg ctg ate aag gcg atg cca cag gtg att gcg gcg cgc cca gat 787 Asp Ser Leu He Lys Ala Met Pro Gln Val He Ala Ala Arg Pro Asp 215 220 225 gcg cag ttg etc att gtg ggc agt ggg cga tac gag tcg act ttg cgg 835 Wing Gln Leu Leu He Val Gly Ser Gly Arg Tyr Glu Ser Thr Leu Arg 230 235 240 245 • cgc ctt gcc act gac gtg age cag aac gtg aaa ttc ctt ggg cgc ctt 883 Arg Leu Wing Thr Asp Val Ser Gln Asn Val Lys Phe Leu Gly Arg Leu 250 255 260 gaa tat ca g gat atg ate aac acg ctt gcc gcc gca gat att tcc gcg 931 Glu Tyr Gln Asp Met He Asn Thr Leu Wing Wing Wing Asp He Phe Wing 265 270 275 atg cca gcg cgc acc cgc ggt ggc ggac gtt ctt gat gtt gag ggc tgc ggc 979 Met Pro Wing Arg Thr Arg Gly Gly Gly Leu Asp Val Glu Gly Leu Gly 280 285 290 att gtc tat etc gag gca ca gcc tgc gga gtg ccg gtg ata gcc ggc 1027 He Val Tyr Leu Glu Ala Gln Ala Cys Gly Val Pro Val He Wing Gly 295 300 305 acc tet ctg gtt 1075 10 ggc ggc gcg cca gag acg gtg act ccg gca act ggc Thr Ser Gly Gly Wing Pro Glu Thr Val Thr Pro Wing Thr Gly Leu Val 310 315 320 325 • gtg gag ggg tcg gac gtc gat aag ctg tet gag ctt tta att gag ctt 1123 Val Glu Gly Ser Asp Val Asp Lys Leu Ser Glu Leu Leu He Glu Leu 330 335 340 etc gac gat ccc ccc gcg gcg gcg atg ggc gct gc ggt agg gcg 1171 Leu Asp Asp Pro He Arg Arg Ala Wing Ala Gly Ala Wing Gly Arg Ala 345 350 355 cat gtg gag gcc gag tgg tgg tgg gag ate atg ggg gag cgg ttg acc 1219 His Val Glu Wing Glu Trp Ser Trp Glu He Met Gly Glu Arg Leu Thr 360 365 370 aat att ttg cag agt gaa cca cga tgatggttgg acagctgttg at: a 1266 15 Asn He Leu Gln Ser Glu Pro Arg 375 380 < 210 > 178 < 211 > 381 < 212 > PRT < 213 > Corynebacterium glutamicum ^ < 400 > 178 Val Ser Wing Being Arg Lys Thr Leu Val Val Thr Asn Asp Phe Pro Pro 1 5 10 15 Arg He Gly Gly He Gln Ser Tyr Leu Arg Asp Phe 20 He Wing Thr Gln 20 25 30 Asp Pro Glu Ser He Val Val Phe Ala Ser Thr Gln Asn Wing Glu Glu 35 40 45 Wing His Wing Tyr Asp Lys Thr Leu Asp Tyr Glu Val He Arg Trp Pro 50 55 60 Arg Ser Val Met Leu Pro Thr Pro Thr Thr Wing His Wing Met Wing Ala Glu 65 70 75 80 He He Arg Glu Arg Glu He Asp Asn Val Trp Phe Gly Ala Wing Wing 85 90 95 Pro Leu Ala Leu Met Wing Gly Thr Wing Lys Gln Wing Gly Wing Ser Lys 100 105 110 Val He Wing Ser Thr His Gly His Glu Val Gly Trp Ser Met Leu Pro 25 ... .AA, *. T ... J. 115 120 125 Gly Ser Arg Gln Ser Leu Arg Lys He Gly Thr Glu Val Asp Val Leu 130 135 140 Thr Tyr He Ser Gln Tyr Thr Leu Arg Arg Phe Lys Ser Wing Phe Gly 145 150 155 160 Ser His Pro Thr Phe Glu His Leu Pro Ser Gly Val Asp Val Lys Arg 165 170 175 Phe Thr Pro Wing Thr Pro Glu Asp Lys Ser Wing Thr Arg Lys Lys Leu 180 185 190 Gly Phe Thr Asp Thr Thr Pro Val He Wing Cys Asn Ser Arg Leu Val 195 200 205 Pro Arg Lys Gly Gln Asp Ser Leu He Lys Wing Met Pro Gln Val He 210 215 220 Wing Wing Arg Pro Asp Wing Gln Leu Leu He Val Gly Ser Gly Arg Tyr 225 230 235 240 Glu Ser Thr Leu Arg Arg Leu Wing Thr Asp Val Ser Gln Asn Val Lys 245 250 255 Phe Leu Gly Arg Leu Glu Tyr Gln Asp Met He Asn Thr Leu Ala Wing 260 265 270 Wing Asp He Phe Wing Met Pro Wing Arg Thr Arg Gly Gly Gly Leu Asp 275 280 285 10 Val Glu Gly Leu Gly He Val Tyr Leu Glu Wing Gln Wing Cys Gly Val 290 295 300 Pro Val He Wing Gly Thr Ser Gly Gly Wing Pro Glu Thr Val Thr Pro • 305 310 315 320 Wing Thr Gly Leu Val Val Glu Gly Ser Asp Val Asp Lys Leu Ser Glu 325 330 335 Leu Leu He Glu Leu Leu Asp Asp Pro He Arg Arg Ala Wing Met Gly 340 345 350 Wing Wing Gly Arg Wing His Val Glu Wing Glu Trp Ser Trp Glu He Met 355 360 365 Gly Glu Arg Leu Thr Asn He Leu Gln Ser Glu Pro Arg 370 375 15 380 < 210 > 179 < 211 > 1287 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > • < 221 > CDS < 222 > (101) .. (1264) < 223 > RXN02595 < 400 > 179 20 gtgggtaaag gggactccga ggaagtccac gtcgtcttct ttcgcggcgc tgaggatggt 60 ttcgcggatt tgtgcggggg agtgggtggg agagaaaacg gtg ate gtt gtg gcc 115 Val He Val Val Ala 1 5 atg gct tcc att atg gct tgt tta aaa gca gct aga ctg aat aac ect 163 Met Ala Ser He Met Ala Cys Leu Lys Wing Wing Arg Leu Asn Asn Pro 10 15 20 atg aag ate ctt ttg ttg tgc tgg cgt gat ac act cat ect ca ggt 211 Met Lys He Leu Leu Leu Cys Trp Arg Asp Thr Thr His Pro Gln Gly 25 30 35 ggc gga agt gaa cgc tat ctg gag cgg gtg ggt gag ttt ttg gcg gat 259 25 Gly Gly Ser Glu Arg Tyr Leu Glu Arg Val Gly Glu Phe Leu Ala Asp . .. * ¡£ SJ £ 40 45 50 cag ggc cat gag gtg gtg ttt cgt act gct ggg falls acg gat gcg cca 307 Gln Gly His Glu Val Val Phe Arg Thr Ala Gly His Thr Asp Ala Pro 55 60 65 cgg cgt tet ttc cgc gat ggt gtg agg tat tcc agg age ggt ggg aag 355 Arg Arg Ser Phe Arg Asp Gly Val Arg Tyr Ser Arg Ser Gly Gly Lys 70 75 80 85 ttt agt gtg tat ccc aag gcg tgg gtg gcc atg átg ttg ggt cgt gtg 403 • Phe Ser Val Tyr Pro Lys Wing Trp Val Wing Met Met Met Leu Gly Arg Val 90 95 100 ggg att ggc acg ttt tct aag gtt gat gtg gtg gat acg cag aat 451 Gly He Gly Thr Phe Ser Lys Val Asp Val Val Val Asp Thr Gln Asn 105 110 115 ggc att ccg ttt ttt gga aag ttt ttc tcc ggt aag ccg act gtg ttg 499 Gly He Pro Phe Phe Gly Lys Phe Phe Ser Gly Lys Pro Thr Val Leu 120 125 130 etc acg cat cat tgc cat aag gag cag tgg ccg gtg gtg ggt cgg gtg 547 Leu Thr His His Cys His Lys Glu Gln Trp Pro Val Val Gly Arg Val 135 140 145 ctg gcg aag gtt ggt tgg ctg att gag age cag ate gcg ccg cgc gct 595 10 Leu Ala Lys Val Gly Trp Leu He Glu Be Gln He Wing Pro Arg Wing 150 155 160 165 tac aaa act gcg ccg tat gtg act gtt tea gag ccg age gct gag gag 643 • Tyr Lys Thr Wing Pro Tyr Val Thr Val Ser Glu Pro Ser Wing Glu Glu 170 175 180 etc att gcg ttg ggt gtg gat cag cag cgg att cat ate gtg cgc aat 691 Leu He Ala Leu Gly Val Asp Gln Gln Arg He His He Val Arg Asn 185 190 195 ggc gtg gat ccc gtg ccg ctg falls acg ccg aag ctg gat ggc ggc 739 Gly Val Asp Pro Val Leu His Thr Pro Lys Leu Asp Arg Asp Gly 200 205 210 cag cat gcg gtg acg ttg tcg cgc ctg gtt ccg falls aag cag att gag 787 15 Gln His Wing Val Thr Leu Ser Arg Leu Val Pro His Lys Gln He Glu 215 220 225 cat gcg atg gat gtc gtc gcg gcg etc gac ggc gtg gtg ctg gat gta 835 His Ala Met Asp Val Val Ala Ala Leu Asp Gly Val Val Leu Asp Val 230 235 240 245 gtc gaa age ggt tgg tgg cag aag gaa ctg gtc gat ta gcc cgc acg 883 Val Glu Ser Gly Trp Trp Gln Lys Glu Leu Val Asp Tyr Ala Arg Thr 250 255 260 • ctg ggt gtg age gat cgc gtg gtt ttc falls ggc cag gtc gcc gag gat 931 Leu Gly Val Ser Asp Arg Val Val Phe His Gly Gln Val Ala Glu Asp 265 270 275 falls aag falls gcc ctg ttg gag c gc gcc acg att cat etc atg ect tcg 979 20 His Lys His Wing Leu Leu Glu Arg Wing Thr He His Leu Met Pro Ser 280 285 290 cgc aag gaa ggc tgg ggc ctg gcg gtc acg gag gcg gcg cag drops ggc 1027 Arg Lys Glu Gly Trp Gly Leu Wing Val Thr Glu Wing Wing Gln His Gly 295 300 305 gtt ccg acg ate ggt tac cga age tea ggc ggc ctg cgc gat tcc gtc 1075 Val Pro Thr He Gly Tyr Arg Ser Ser Gly Leu Arg Asp Ser Val 310 315 320 325 gtc gac ggc gaa acc ggc ctg ctt gtc gac tcc aag gcc gag ctt att 1123 Val Asp Gly Glu Thr Gly Leu Leu Val Asp Ser Lys Wing Glu Leu He 330 335 340 tea gcc acc aaa acc ctg ctt ate gac gcc tcc etc cgc tcc aag etc 1171 25 Ser Ala Thr Lys Thr Leu Leu He Asp Ala Ser Leu Arg Ser Lys Leu K ¿k & j a & .¿, -í-. "^ & ¿£ ^ t..É 345 350 355 ggc gcc age gcg aag cag cgc gcc gaa aae tac aag tgg gac acc gcg 1219 Gly Ala Ser Ala Lys Gln Arg Ala Glu Asn Tyr Lys Trp Asp Thr Ala 360 365 370 gga gcg cag ttc gag gaa cta ctt ctt ggt ctt gcg tcg aaa aag 1264 Gly Wing Gln Phe Glu Glu Leu Leu Leu Gly Leu Wing Ser Lys Lys 375 380 385 tagtcccagc ggcaacgcca tcc 1287 • < 210 > 180 < 211 > 388 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 180 Val He Val Val Ala Ala Ala Ala Be He Met Ala Cys Leu Lys Ala Ala 1 5 10 15 Arg Leu Asn Asn Pro Met Lys He Leu Leu Leu Cys Trp Arg Asp Thr 20 25 30 Thr His Pro Gln Gly Gly Gly Ser Glu Arg Tyr Leu Glu Arg Val Gly 10 35 40 45 Glu Phe Leu Wing Asp Gln Gly His Glu Val Val Phe Arg Thr Wing Gly 50 55 60 His Thr Asp Ala Pro Arg Arg Ser Phe Arg Asp Gly Val Arg Tyr Ser # 65 70 75 80 Arg Ser Gly Gly Lys Phe Ser Val Tyr Pro Lys Wing Trp Val Wing Met 85 90 95 Met Leu Gly Arg Val Gly He Gly Thr Phe Ser Lys Val Asp Val Val 100 105 110 Val Asp Thr Gln Asn Gly He Pro Phe Phe Gly Lys Phe Phe Ser Gly 115 120 125 Lys Pro Thr Val Leu Leu Thr His His Cys His Lys Glu Gln Trp Pro 15 130 135 140 Val Val Gly Arg Val Leu Ala Lys Val Gly Trp Leu He Glu Ser Gln 145 150 155 160 He Ala Pro Arg Ala Tyr Lys Thr Ala Pro Tyr Val Thr Val Ser Glu 165 170 175 Pro Ser Ala Glu Glu Leu He Ala Leu Gly Val Asp Gln Gln Arg He 180 185 190 His He Val Val Asg Gly Val Asp Pro Val Leu His Thr Pro Lys 195 200 205 Leu Asp Arg Asp Gly Gln His Wing Val Thr Leu Ser Arg Leu Val Pro 210 215 220 His Lys Gln He Glu His Wing Met Asp Val Val Wing Wing Leu Asp Gly 20 225 230 235 240 Val Val Leu Asp Val Val Glu Ser Gly Trp Trp Gln Lys Glu Leu Val 245 250 255 Asp Tyr Ala Arg Thr Leu Gly Val Ser Asp Arg Val Val Phe His Gly 260 265 270 Gln Val Wing Glu Asp His Lys His Wing Leu Leu Glu Arg Wing Thr He 275 280 285 His Leu Met Pro Ser Arg Lys Glu Gly Trp Gly Leu Wing Val Thr Glu 290 295 300 Wing Wing Gln His Gly Val Pro Thr He Gly Tyr Arg Ser Ser Gly Gly 305 310 315 320 Leu Arg Asp Ser Val Val Asp Gly Glu Thr Gly Leu Leu Val Asp Ser 25 325 330 335 ^^ jg ^ jj 'dfe «nAj Lys Wing Glu Leu He Ser Wing Thr Lys Thr Leu Leu He Asp Wing Ser 340 345 350 Leu Arg Ser Lys Leu Gly Wing Wing Wing Lys Gln Arg Wing Glu Asn Tyr 355 360 365 Lys Trp Asp Thr Ala Gly Ala Gln Phe Glu Glu Leu Leu Leu Gly Leu 370 375 380 Wing Ser Lys Lys 385 • < 210 > 181 < 211 > 2334 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (2311) < 223 > RXS00148 < 400 > 181 10 ctttgagggc, agcgcgcatg cgcccgatgg ttatttigaac atgacaaittg; atgcicgcggc 60 gacgctggct igacetget; ag atgctttggg agettaaate atg acg tcg ate ect 115 Met Thr Ser He Pro 1 5 • aat ttt tea gac ate cca ttg act gct gag ac cgt gca tcg gag tea 163 Asn Phe Being Asp He Pro Leu Thr Wing Glu Thr Arg Wing Ser Glu Ser 10 15 20 falls aac gtt gac gcc ggc aag gtg tgg aac act ccc gaa ggc att gat 211 His Asn Val Asp Wing Gly Lys Val Trp Asn Thr Pro Glu Gly He Asp 25 30 35 gtc aag cgc gta ttc acg cag gct gac cgc gac gcg ca gcg gcg 259 Val Lys Arg Val Phe Thr Gln Wing Asp Arg Asp Glu Wing Gln Ala Wing 15 40 45 50 gga cat ccg gtg gat tet ttg cca ggt ca aag cca ttt atg cgc ggg 307 Gly His Pro Val Asp Ser Leu Pro Gly Gln Lys Pro Phe Met Arg Gly 55 60 65 ccg tac cca act atg tac acc aat cag ccg tgg acg att cgc cag tac 355 Pro Tyr Pro Thr Met Tyr Thr Asn Gln Pro Trp Thr He Arg Gln Tyr 70 75 80 85 gca ggc ttt tea acc gcc gcg gaa tcc aat gcg ttt tat cgg agg aac 403 • Wing Gly Phe Ser Thr Wing Wing Glu Being Asn Wing Phe Tyr Arg Arg Asn 90 95 100 ctt gct gcg ggt caa aaa ggt ttg tcg gtt gcg ttc gatta gcg acc 451 Leu Wing Wing Gly Gln Lys Gly Leu Ser Val Wing Phe Asp Leu Ala Thr 20 105 110 115 fall cgc ggt tat gac tcg gat aat gag cgc gtg gtc ggc gat gtg ggt 499 His Arg Gly Tyr Asp Ser Asp Asn Glu Arg Val Val Gly Asp Val Gly 120 125 130 atg gcc ggc gtg gcg att gat tcg att ttg gat atg cgt cag ctg ttt 547 Met Ala Gly Val Ala He Asp Ser He Leu Asp Met Arg Gln Leu Phe 135 140 145 gat ggc att gat ttg tcc age gtg tcg gtg tcg atg acc atg aat ggc 595 Asp Gly He Asp Leu Ser Ser Val Ser Val Met Met Met Met Gly 150 155 160 165 gct gtg ctg ccg att ctt gcg ttc tat ate gtg gcg gct gag gaa caa 643 Wing Val Leu Pro He Leu Wing Phe Tyr He Val Wing Wing Glu Glu Gln 25 170 175 180 ggt ggg ggt cgg gag cag ctt gcg ggc acg ate cag aat gac ate ttg 691 Gly Val Gly Pro Glu Gln Leu Wing Gly Thr He Gln Asn Asp He Leu 185 190 195 aaa gaa ttt atg gtg cgc aac tat tat att tat ccg ccg aag ccg tcg 739 Lys Glu Phe Met Val Arg Asn Thr Tyr He Tyr Pro Pro Lys Pro Ser 200 205 210 atg cgc ate att tcc aac ate ttt gag tac acc tcc ttg aag atg cca 787 Met Arg He He Ser Asn He Phe Glu Tyr Thr Ser Leu Lys Met Pro • 215 220 225 cgt ttt aac tcc att tcg att tet ggc tat cae ate cag gaa gcg gga 835 Arg Phe Asn Ser He Ser Be Ser Gly Tyr His He Gln Glu Ala Gly 230 235 240 245 gcg act gcc gat ttg gag ctg gcc tac act ctg gcg gat ggt att gaa 883 Wing Thr Wing Asp Leu Glu Leu Wing Tyr Thr Leu Wing Asp Gly He Glu 250 255 260 tac ate cgt gca ggt aaa gag gta ggc ctt gac gtg gat aag tcc gcg 931 Tyr He Arg Ala Gly Lys Glu Val Gly Leu Asp Val Asp Lys Phe Wing 265 270 275 ect cgt ctg tcc ttc ttc tgg ggt att tet atg tac acc ttc atg gag 979 Pro Arg Leu Ser Phe Phe Trp Gly He Ser Met Tyr Thr Phe Met Glu 10 280 285 290 ate gca aag ctg cgt gcg gga cga ctg ctg tgg age gag ttg gtg gca 1027 He Ala Lys Leu Arg Ala Gly Arg Leu Leu Trp Ser Glu Leu Val Ala • 295 300 305 aaa ttc gat ccg aaa aac gcc aag tcc cag tcg ctg cgc acg cae tcg 1075 Lys Phe Asp Pro Lys Asn Ala Lys Ser Gln Ser Leu Arg Thr His Ser 310 315 320 325 cag acc tet ggt tgg tcg ttg acc gcg cag gat gtg tac aac aac gtc 1123 Gln Thr Ser Gly Trp Ser Leu Thr Wing Gln Asp Val Tyr Asn Asn Val 330 335 340 gcc cgc acc gcg att gag gcg atg gct gca acc cag ggc falls acc cag 1171 Wing Arg Thr Wing He Glu Wing Wing Wing Wing Thr Gln Gly His Thr Gln 15 345 350 355 tcg ctg falls acc eat gca ctt gat gag gcg ttg gcg ctg ccc acc gat 1219 Ser Leu His Thr Asn Wing Leu Asp Glu Wing Leu Wing Leu Pro Thr Asp 360 365 370 ttc tet gct cgt ate gcc cga aac accc cg ttg ctg cag cag gaa 1267 Phe Be Wing Arg He Wing Arg Asn Thr Gln Leu Leu Leu Gln Gln Glu 375 380 385 tet ggc acg gtg cgt cca gtt gat cca tgg gcg ggc tcc tat tac gtg 1315 Be Gly Thr Val Arg Pro Val Asp Pro Trp Wing Gly Ser Tyr Tyr Val 390 395 400 405 gag tgg tgt agag gact ctg gct aac cgc gcg cgc aag fall gat 1363 Glu Trp Leu Thr Asn Glu Leu Wing Asn Arg Wing Arg Lys His He Asp 20 410 415 420 gag gtg gag gac gcc ggc gga atg gcg cag gcc acc gcg cag gga att 1411 Glu Val Glu Glu Wing Gly Gly Met Wing Gln Wing Thr Wing Gln Gly He 425 430 435 ect aag ctg cgc att gag gaa tea gcg gca cgc acc cag gct cgc att 1459 Pro Lys Leu Arg He Glu Glu Be Wing Wing Arg Thr Gln Wing Arg He 440 445 450 gat tcc ggc cgc cag gcg ctg ate ggc gtg aat cgc tac gtg gcg gaa 1507 Asp Ser Gly Arg Gln Ala Leu He Gly Val Asn Arg Tyr Val Ala Glu 455 460 465 gaa gat gag gaa att gaa gtc etc aag gtt gac aac acc aag gtt cgc 1555 Glu Asp Glu Glu He Glu Val Leu Lys Val Asp Asn Thr Lys Val Arg 25 470 475 480 485 ... i * iiU, gca gaa cag ttg gct aaa etc gcg caa ctg aaa gca gag cgc aac gat 1603 Wing Glu Gln Leu Wing Lys Leu Wing Gln Leu Lys Wing Glu Arg Asn Asp 490 495 500 gcg gaa gtc aag gct gcg ctg gat gcg ttg here gct gct gcc cgc aac 1651 Wing Glu Val Lys Wing Wing Leu Asp Wing Leu Thr Wing Wing Wing Arg Asn 505 510 515 gag cat aaa gag cca ggg gat ttg gat cag aac ctg etc aaa ctt gcc 1699 Glu His Lys Glu Pro Gly Asp Leu Asp Gln Asn Leu Leu Lys Leu Wing 520 525 530 • gtc gat gct gcg cgc gca aaa gct acc att gga gag ate tct gat gct 1747 Val Asp Ala Ala Arg Ala Lys Ala Thr He Gly Glu He Ser Asp Ala 535 540 545 ttg gaa gtt gtc ttt ggc cgc falls gaa gca gaa ate agg acg ctg tet 1795 Leu Glu Val Val Phe Gly Arg His Glu Ala Glu He Arg Thr Leu Ser 550 555 560 565 ggc gtg tac aag gat gag gtt gga aag gaa ggc here gtg age aac gtc 1843 Gly Val Tyr Lys Asp Glu Val Gly Lys Glu Gly Thr Val Ser Asn Val 570 575 580 gaa cgc gcg ate gcc ctg gct gac gcc ttt gag gct gag gaa ggc cgc 1891 Glu Arg Wing Wing Wing Leu Wing Asp Wing Phe Glu Wing Glu Glu Gly Arg 585 590 595 10 cgc cca cgt ate ttt att gcc aag atg ggc cag gat gga cat gac cgt 1939 Arg Pro Arg He Phe He Wing Lys Met Gly Gln Asp Gly His Asp Arg 600 605 610 • gga cag aag gtt gtc gcg tet gcc tat gct gac ctg ggc atg gac gtg 1987 Gly Gln Lys Val Val Wing Being Wing Tyr Wing Asp Leu Gly Met Asp Val 615 620 625 gat gtt ggc ccg ctg ttt cact act cca gcc gc gct gcc cgc gcc gcc 2035 Asp Val Gly Pro Leu Phe Gln Thr Pro Wing Glu Wing Wing Arg Wing Wing 630 635 640 645 gtg gac gcc gat gtt fall gtg gtg ggt atg tet tcg ctg gca gca ggc 2083 Val Asp Wing Asp Val His Val Val Gly Met Ser Ser Leu Wing Wing Gly 650 655 660 15 falls etc acc ttg ctg ccc gag ctg aag aaa gaa ctt gca gct ctt ggc 2131 His Leu Leu Leu Leu Pro Glu Leu Lys Lys Glu Leu Ala Wing Leu Gly 665 670 675 cgc gat gac att ctg gtc gtc acc ggc ggc gtc att ccg ccg ggc gat 2179 Arg Asp Asp He Leu Val Thr Val Gly Gly Val He Pro Pro Gly Asp 680 685 690 ttc cag gat etc tac gat atg ggt gcc gcc gcg att tac ect tea gga 2227 Phe Gln Asp Leu Tyr Asp Met Gly Wing Wing Wing He Tyr Pro Ser Gly 695 700 705 gtc ate gcc gcg gag tcg gcg gcg ate gat ctg ate gcc acc gga etc gcc 2275 Thr Val He Wing Glu Wing Wing He Asp Leu He Thr Arg Leu Wing Wing 710 715 720 725 20 falls ctg ggc ttt gac ctg gat gtg gat gtg aat gaa tgat • .cacggt 2321 His Leu Gly Phe Asp Leu Asp Val Asp Val Asn Glu 730 735 ttcctagaag here 2334 < 210 > 182 < 211 > 737 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 182 25 Met Thr Ser He Pro Asn Phe Be Asp He Pro Leu Thr Wing Glu Thr 1 5 10 15 Arg Wing Ser Glu Ser His Asn Val Asp Wing Gly Lys Val Trp Asn Thr 20 25 30 Pro Glu Gly He Asp Val Lys Arg Val Phe Thr Gln Wing Asp Arg Asp 35 40 45 Glu Wing Gln Wing Wing Gly His Pro Val Asp Ser Leu Pro Gly Gln Lys 50 55 60 Pro Phe Met Arg Gly Pro Tyr Pro Thr Met Tyr Thr Asn Gln Pro Trp 65 70 75 80 • Thr He Arg Gln Tyr Wing Gly Phe Ser Thr Wing Wing Glu Ser Asn Wing 85 90 95 Phe Tyr Arg Arg Asn Leu Wing Wing Gly Gln Lys Gly Leu Ser Wing 100 105 110 Phe Asp Leu Wing Thr His Arg Gly Tyr Asp Being Asp Asn Glu Arg Val 115 120 125 Val Gly Asp Val Gly Met Wing Gly Val Wing Asp Ser He Leu Asp 130 135 140 Met Arg Gln Leu Phe Asp Gly He Asp Leu Ser Val Val Ser 145 150 155 160 Met Thr Met Asn Gly Wing Val Leu Pro He Leu Wing Phe Tyr He Val 165 170 175 10 Wing Wing Glu Glu Gln Gly Val Gly Pro Glu Gln Leu Wing Gly Thr He 180 185 190 Gln Asn Asp He Leu Lys Glu Phe Met Val Arg Asn Thr Tyr He Tyr • 195 200 205 Pro Pro Lys Pro Ser Met Arg He He Ser Asn He Phe Glu Tyr Thr 210 215 220 Ser Leu Lys Met Pro Arg Phe Asn Ser Be Ser Be Gly Tyr His 225 230 235 240 He Gln Glu Ala Gly Ala Thr Wing Asp Leu Glu Leu Wing Tyr Thr Leu 245 250 255 Wing Asp Gly He Glu Tyr He Arg Wing Gly Lys Glu Val Gly Leu Asp 260 265 270 15 Val Asp Lys Phe Wing Pro Arg Leu Ser Phe Phe Trp Gly He Ser Met 275 280 285 Tyr Thr Phe Met Glu He Wing Lys Leu Arg Wing Gly Arg Leu Leu Trp 290 295 300 Ser Glu Leu Val Wing Lys Phe Asp Pro Lys Asn Wing Lys Ser Gln Ser 305 310 315 320 Leu Arg Thr His Ser Gln Thr Ser Gly Trp Ser Leu Thr Ala Gln Asp • 325 330 335 Val Tyr Asn Asn Val Wing Arg Thr Wing He Glu Wing Wing Ala Wing Thr 340 345 350 Gln Gly His Thr Gln Ser Leu His Thr Asn Wing Leu Asp Glu Wing Leu 355 360 365 20 Wing Leu Pro Thr Asp Phe Ser Wing Arg He Wing Arg Asn Thr Gln Leu 370 375 380 Leu Leu Gln Gln Glu Ser Gly Thr Val Arg Pro Val Asp Pro Trp Wing 385 390 395 400 Gly Ser Tyr Tyr Val Glu Trp Leu Thr Asn Glu Leu Wing Asn Arg Wing 405 410 415 Arg Lys His He Asp Glu Val Glu Glu Wing Gly Gly Met Wing Gln Wing 420 425 430 Thr Wing Gln Gly He Pro Lys Leu Arg He Glu Glu Be Wing Wing Arg 435 440 445 Thr Gln Wing Arg He Asp Ser Gly Arg Gln Wing Leu He Gly Val Asn 25 450 455 460 Arg Tyr Val Wing Glu Glu Asp Glu Glu He Glu Val Leu Lys Val Asp 465 470 475 480 Asn Thr Lys Val Arg Ala Glu Gln Leu Ala Lys Leu Ala Gln Leu Lys 485 490 495 Ala Glu Arg Asn Asp Ala Glu Val Lys Ala Ala Ala Leu Asp Ala Leu Thr 500 505 510 Ala Ala Ala Arg Asn Glu His Lys Glu Pro Gly Asp Leu Asp Gln Asn 515 520 525 Leu Leu Lys Leu Ala Val Asp Ala Ala Arg Ala Lys Ala Thr He Gly 530 535 540 Glu He Ser Asp Ala Leu Glu Val Val Phe Gly Arg His Glu Ala Glu 545 550 555 560 He Arg Thr Leu Ser Gly Val Tyr Lys Asp Glu Val Gly Lys Glu Gly 565 570 575 Thr Val Ser Asn Val Glu Arg Ala He Ala Leu Wing Asp Wing Phe Glu 580 585 590 Wing Glu Glu Gly Arg Arg Pro Arg He Phe He Wing Lys Met Gly Gln 595 600 605 Asp Gly His Asp Arg Gly Gln Lys Val Val Wing Wing Wing Tyr Wing Asp 610 615 620 10 Leu Gly Met Asp Val Asp Val Gly Pro Leu Phe Gln Thr Pro Ala Glu 625 630 635 640 Ala Ala Arg Ala Ala Asp Ala Asp Val His Val Val Gly Met Ser • 645 650 655 Ser Leu Ala Ala Gly His Leu Thr Leu Leu Pro Glu Leu Lys Lys Glu 660 665 670 Leu Wing Wing Leu Gly Arg Asp Asp He Leu Val Thr Val Gly Val 675 680 685 He Pro Pro Gly Asp Phe Gln Asp Leu Tyr Asp Met Gly Ala Wing Wing 690 695 700 He Tyr Pro Ser Gly Thr Val He Wing Glu Wing Wing He Asp Leu He 705 710 715 720 15 Thr Arg Leu Ala Wing His Leu Gly Phe Asp Leu Asp Val Asp Val Asn 725 730 735 Glu < 210 > 183 < 211 > 1971 < 212 > DNA < 213 > Corynebacterium glutamicum • < 220 > < 221 > CDS < 222 > (101) .. (1948) 20 < 223 > RXS00149 < 400 > 183 ttttcgtagg taaacacagg tgaaggettt acaagettgt gaactcccta cacaaaagea 60 atecaatage tatecataag caagagaaag taagtctacg ttg act gat etc here 115 Leu Thr Asp Leu Thr 1 5 aag act gcg gtg ccc gag gaa ctt tea gag aac etc gaa act tgg tac 163 Lys Thr Ala Val Pro Glu Glu Leu Ser Glu Asn Leu Glu Thr Trp Tyr 10 15 20 aag gct gc gc ggt gtt tcc gcg cgc here cag aaa aaa gac ate gcc 211 Lys Ala Val Ala Gly Val Phe Ala Arg Thr Gln Lys Lys Asp He Gly 25 25 30 35 wtMJ? .íí .. i ___________ gac att gcc gta gat gtg tgg aag aaa etc ate gtc act here ccg gat 259 Asp He Ala Val Asp Val Trp Lys Lys Leu He Val Thr Thr Pro Asp 40 45 50 ggt gtt gat ate ate aat ccg ctg tac acc aga gca gat gag tcc cag agg 307 Gly Val Asp He Asn Pro Leu Tyr Thr Arg Wing Asp Glu Ser Gln Arg 55 60 65 aaa ttc act gag gtt ect ggt gag ttt ccc ttc act agg gga acc act 355 Lys Phe Thr Glu Val Pro Gly Glu Phe Pro Phe Thr Arg Gly Thr Thr 70 75 80 85 • gtt gat ggt gaa cgc gtt ggg tgg ggt gtt act gag act ttc gga cat 403 Val Asp Gly Glu Arg Val Gly Trp Gly Val Thr Glu Thr Phe Gly His 90 95 100 gac age ccg aag aat ate aac gct gcg gtg ctg aat gct ctg aat tet 451 Asp Ser Pro Lys Asn He Asn Ala Ala Val Leu Asn Ala Leu Asn Ser 105 110 115 ggc acc ac ttg ggt ttt gag ttc tet gag gaa ttc acg gca gct 499 Gly Thr Thr Leu Gly Phe Glu Phe Ser Glu Glu Phe Thr Ala Wing 120 125 130 gat ctt aaa gtt gct etc gaa ggc gtg tat etc aac atg gct ccg ttg 547 Asp Leu Lys Val Wing Leu Glu Gly Val Tyr Leu Asn Met Wing Pro Leu 10 135 140 145 ctg att cat gcg ggt gga tcc acg tea gag gtt gca gcg gcg ttg tat 595 Leu He His Wing Gly Gly Ser Thr Ser Glu Val Wing Wing Wing Leu Tyr 150 155 160 165 • acg ttg gcg gag gaa gcc gga acg ttt ttt gct gcg ttg acc ttg ggt 643 Thr Leu Wing Glu Glu Wing Gly Thr Phe Phe Wing Wing Leu Thr Leu Gly 170 175 180 tet cgt ect ttg acg gcg cag gtt gat ggt tcg falls agt gac acc att 691 Ser Arg Pro Leu Thr Ala Gln Val Asp Gly Ser His Ser Asp Thr He 185 190 195 gaa gaa gca gtt cag ttg gca gtg aat gct tcc aag cgt gcg aat gtg 739 Glu Glu Wing Val Gln Leu Wing Val Asn Wing Ser Lys Arg Wing Asn Val 15 200 205 210 cgc gct ate ttg gtg gat ggt tcc agt ttt tcc aac cag ggc gcg tcg 787 Arg Ala He Leu Val Asp Gly Ser Ser Phe Ser Asn Gln Gly Wing Ser 215 220 225 gat gct caa gaa att ggt cta agt ate gcc gcc ggt gtg gat tat gtc 835 Asp Ala Gln Glu He Gly Leu Ser He Ala Ala Gly Val Asp Tyr Val 230 235 240 245 cgt cgc ttg gtc ggc gat gca cct tc acg gaa gct gca ctt aag cag 883 Arg Arg Leu Val Asp Wing Gly Leu Ser Thr Glu Wing Wing Leu Lys Gln • 250 255 260 gtg gcg ttc cgt ttt gcg gtc acc gat gag cag ttc gcg cag att tet 931 Val Wing Phe Arg Phe Wing Val Thr Asp Glu Gln Phe Wing Gln He Ser 20 265 270 275 aag ctg cgt gtg gct cga cgt ctg tgg gcc agg gtg tgt gag gtg ctt 979 Lys Leu Arg Val Ala Arg Arg Leu Trp Wing Arg Val Cys Glu Val Leu 280 285 290 ggt ttt cca gag ctg gcc gta gca cca cag cat gcg gtg act gca cga 1027 Gly Phe Pro Glu Leu Wing Val Wing Pro Gln His Wing Val Thr Wing Arg 295 300 305 gcg atg ttt age cag cgt gat ccg tgg gtg aat atg ctg cgc agt act 1075 Wing Met Phe Ser Gln Arg Asp Pro Trp Val Asn Met Leu Arg Ser Thr 310 315 320 325 gtt gc gct tcc gct gca gcc gtc ggt gga gca acc gat gtg gag gtt 1123 Val Ala Ala Phe Ala Ala Gly Val Gly Gly Ala Thr Asp Val Glu Val 25 330 335 340 cgt act ttt gat gat gcg ate cca gat gga gtt ect gga gtg tcg agg 1171 Arg Thr Phe Asp Asp Ala He Pro Pro Asp Gly Val Pro Gly Val Ser Arg 345 350 355 aat ttc gct falls cgc ate gcg cgc aat act aat ttg ttg ttg cta gaa 1219 Asn Phe Ala His Arg He Ala Arg Asn Thr Asn Leu Leu Leu Leu Glu 360 365 370 gag tea cat ctt ggt falls gtg gtt gat ect gct ggt gga tea tat ttc 1267 Glu Ser His Leu Gly His Val Val Asp Pro Wing Gly Gly Ser Tyr Phe 375 380 385 gtg gag age ttc acc gat gat cta gcg gag aag gcg tgg gct gtg ttc 1315 Val Glu Ser Phe Thr Asp Asp Leu Wing Glu Lys Wing Trp Wing Val Phe 390 395 400 405 agt ggc ate gaa gct gag ggc gga tac ag gca gct tgt gca tcc ggc 1363 Ser Gly He Glu Wing Glu Gly Gly Tyr Ser Wing Wing Cys Wing Ser Gly 410 415 420 acg gtg act gcc atg ctt gat cag acg tgg gag cag act cgc gct gat 1411 Thr Val Thr Wing Met Leu Asp Gln Thr Trp Glu Gln Thr Arg Wing Asp 425 430 435 gtg gcg tcg aga aag aag aag aga etc act gga att aat gag tcc ccg aac 1459 Val Wing Arg Lys Lys Lys Leu Thr Gly He Asn Glu Phe Pro Asn 10 440 445 450 ttg gcg gag tet ccg ctg cca gct gat cgt cgg gta gaa ect gca ggt 1507 Leu Ala Glu Pro Pro Leu Pro Wing Asp Arg Arg Val Glu Pro Wing Gly • 455 460 465 gtg cgt cga tgg gca gcg gat ttt gaa gcg ctg cgc aat cgt tcg gat 1555 Val Arg Arg Trp Wing Wing Asp Phe Glu Ala Leu Arg Asn Arg Ser Asp 470 475 480 485 gct ttc ttg gaa aag aac ggc gcg agg cca cag ate acg atg att ect 1603 Wing Phe Leu Glu Lys Asn Gly Wing Arg Pro Gln He Thr Met He Pro 490 495 500 ctg gga ccg ttg tcc aag falls aat att cgc act ggt ttt act tcc aac 1651 Leu Gly Pro Leu Ser Lys His Asn He Arg Thr Gly Phe Thr Ser Asn 15 505 510 515 ctg ttg gct tcc ggt ggc att gaa gca ate aac ccg ggt caa ctt gtt 1699 Leu Leu Wing Ser Gly Gly He Glu Wing He Asn Pro Gly Gln Leu Val 520 525 530 ccc ggc act gac gct ttt gca gaa gct gca cag gcc gca ggc att gta 1747 Pro Gly Thr Asp Ala Phe Ala Glu A the Gln Wing Wing Wing Gly He Val 535 540 545 gtg gtg tgt gga acg gac ca gag tat gcc gaa acg ggg gag gga gcc 1795 • Val Val Cys Gly Thr Asp Gln Glu Tyr Ala Glu Thr Gly Glu Gly Ala 550 555 560 565 gtc gaa aag etc cgc gaa gcg ggc gtt gag cgc ate ctg ctt gct ggc 1843 Val Glu Lys Leu Arg Glu Wing Gly Val Glu Arg He Leu Leu Wing Gly 20 570 575 580 gcg ccg aag age ttt gag ggc age gcg cat gcg ccc gat ggt tat ttg 1891 Wing Pro Lys Ser Phe Glu Gly Ser Wing His Wing Pro Asp Gly Tyr Leu 585 590 595 aac atg here att gat gcc gcg gcg acg ctg gct gac ctg cta gat gct 1939 Asn Met Thr He Asp Wing Wing Thr Leu Wing Asp Leu Leu Asp Wing 600 605 610 ttg gga gct taaatcat: ga cgtcgatccc taa 1971 Leu Gly Wing 615 < 210 > 184 25 < 211 > 616 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 184 Leu Thr Asp Leu Thr Lys Thr Wing Val Pro Glu Glu Leu Ser Glu Asn 1 5 10 15 Leu Glu Thr Trp Tyr Lys Wing Val Wing Gly Val Phe Wing Arg Thr Gln 20 25 30 • Lys Lys Asp He Gly Asp He Wing Val Asp Val Trp Lys Lys Leu He 35 40 45 Val Thr Thr Pro Asp Gly Val Asp He Asn Pro Leu Tyr Thr Arg Wing 50 55 60 Asp Glu Ser Gln Arg Lys Phe Thr Glu Val Pro Gly Glu Phe Pro Phe 65 70 75 80 Thr Arg Gly Thr Thr Val Asp Gly Glu Arg Val Gly Trp Gly Val Thr 85 90 95 Glu Thr Phe Gly His Asp Ser Pro Lys Asn He Asn Ala Wing Val Leu 100 105 110 Asn Ala Leu Asn Ser Gly Thr Thr Thr Leu Gly Phe Glu Phe Ser Glu 115 120 125 10 Glu Phe Thr Wing Wing Asp Leu Lys Val Wing Leu Glu Gly Val Tyr Leu 130 135 140 Asn Met Wing Pro Leu Leu He His Wing Gly Gly Ser Thr Ser Glu Val • 145 150 155 160 Ala Ala Ala Leu Tyr Thr Leu Ala Glu Glu Ala Gly Thr Phe Phe Ala 165 170 175 Ala Leu Thr Leu Gly Ser Arg Pro Leu Thr Ala Gln Val Asp Gly Ser 180 185 190 His Ser Asp Thr He Glu Glu Ala Val Gln Leu Ala Val Asn Wing Ser 195 200 205 Lys Arg Wing Asn Val Arg Wing He Leu Val Asp Gly Ser Ser Phe Ser 210 215 220 15 Asn Gln Gly Wing Be Asp Wing Gln Glu He Gly Leu Ser Wing Wing 225 230 235 240 Gly Val Asp Tyr Val Arg Arg Leu Val Asp Wing Gly Leu Ser Thr Glu 245 250 255 Wing Wing Leu Lys Gln Val Wing Phe Arg Phe Wing Val Thr Asp Glu Gln 260 265 270 Phe Wing Gln He Ser Lys Leu Arg Val Wing Arg Arg Leu Trp Wing Arg 275 280 285 Val Cys Glu Val Leu Gly Phe Pro Glu Leu Wing Val Wing Pro Gln His 290 295 300 Wing Val Thr Wing Arg Wing Met Phe Ser Gln Arg Asp Pro Trp Val Asn 305 310 315 320 20 Met Leu Arg Ser Thr Val Wing Wing Phe Wing Wing Gly Val Gly Gly Wing 325 330 335 Thr Asp Val Glu Val Arg Thr Phe Asp Asp Wing Pro Asp Gly Val 340 345 350 Pro Gly Val Ser Arg Asn Phe Wing His Arg He Wing Arg Asn Thr Asn 355 360 365 Leu Leu Leu Leu Glu Glu Ser His Leu Gly His Val Val Asp Pro Wing 370 375 380 Gly Gly Ser Tyr Phe Val Glu Ser Phe Thr Asp Asp Leu Ala Glu Lys 385 390 395 400 Wing Trp Wing Val Phe Ser Gly He Glu Wing Glu Gly Gly Tyr Ser Wing 405 410 415 25 Wing Cys Wing Gly Thr Val Thr Wing Met Leu Asp Gln Thr Trp Glu 420 425 430 Gln Thr Arg Wing Asp Val Wing Ser Arg Lys Lys Lys Leu Thr Gly He 435 440 445 Asn Glu Phe Pro Asn Leu Wing Glu Pro Pro Leu Pro Wing Asp Arg Arg 450 455 460 Val Glu Pro Wing Gly Val Arg Arg Trp Wing Wing Asp Phe Glu Wing Leu 465 470 475 480 Arg Asn Arg Be Asp Wing Phe Leu Glu Lys Asn Gly Wing Arg Pro Gln 485 490 495 • He Thr Met He Pro Leu Gly Pro Leu Ser Lys His Asn He Arg Thr 500 505 510 Gly Phe Thr Ser Asn Leu Leu Wing Ser Gly Gly He Glu Wing He Asn 515 520 525 Pro Gly Gln Leu Val Pro Gly Thr Asp Ala Phe Ala Glu Ala Ala Gln 530 535 540 Ala Ala Gly He Val Val Val Cys Gly Thr Asp Gln Glu Tyr Ala Glu 545 550 555 560 Thr Gly Glu Gly Ala Val Glu Lys Leu Arg Glu Wing Gly Val Glu Arg 565 570 575 He Leu Leu Wing Gly Wing Pro Lys Ser Phe Glu Gly Ser Wing His Wing 10 580 585 590 Pro Asp Gly Tyr Leu Asn Met Thr He Asp Wing Wing Wing Thr Leu Ala 595 600 605 Asp Leu Leu Asp Ala Leu Gly Ala • 610 615 < 210 > 185 < 211 > 1179 < 212 > DNA < 213 > Cc) rynebacter? Um gl .utamicum < 220 > 15 < 221 > CDS < 222 > (101) .. (1156) < 223 > RXS02106 < 400 > 185 ggtcgccgct 1tttcgacgcc cgcctgcggc gggatgactg tgatggaggg gcgcgtcgac 60 aagcaaaatc 1tctttagcaa attcggttac tgtggggcgc atg aat aac cat ttt 115 Met Asn Asn His Phe 1 5 • gag etc aaa gta ect ggt gga aag ctt gtc gtt gtt gat gtg acc acc 163 Glu Leu Lys Val Pro Gly Gly Lys Leu Val Val Val Asp Val Thr Thr 10 15 20 20 gat ctg gattcc att gct gac gtg aag att tcc gcc gat ttc ttc etc 211 Asp Leu Asp Ser He Wing Asp Val Lys He Ser Gly Asp Phe Phe Leu 25 30 35 gaa ccc gat gag gca ttc ttc gcc ctt ggc cgg gcg ctg cag ggg gcg 259 Glu Pro Asp Glu Wing Phe Phe Wing Leu Gly Arg Wing Leu Gln Gly Wing 40 45 50 tcg gtg ggt gat aac act gat ct tg cag gca aag ttg gat gca gcg 307 Ser Val Gly Asp Asn Thr Asp Arg Leu Gln Wing Lys Leu Asp Wing Wing 55 60 65 ttg gcg gaa tat gat gac gtt gag cta fall ggc ttt age act gcg gat 355 Leu Wing Glu Tyr Asp Asp Val Glu Leu His Gly Phe Ser Thr Wing Asp 70 75 80 85 25 att gct tta gct gtg cgt cgg gca gtc acc ggc gcg caa gat ttc acc 403 * j. fc ié.

He has Ala Leu Ala Val Arg Arg Ala Val Thr Gly Ala Gln Asp Phe Thr 90 95 100 gat tat gaa tgg gaa ate ctg falls cca ggg gtg ctt ect acc cca ctt 451 Asp Tyr Glu Trp Glu He Leu His Pro Gly Val Leu Pro Thr Pro Leu 105 110 115 aac gtt gcg ttg gat gag etc ctt ttg gac ca gtt gcc agt ggt cag 499 Asn Val Ala Leu Asp Glu Leu Leu Leu Asp Gln Val Wing Ser Gly Gln 120 125 130 cgt ggc ccg acg atg cgc att tgg gat tgg gat gat cgc gcc gtg 547 Arg Gly Pro Thr Met Arg He Trp Asp Trp Asp Asp Arg Wing Thr Val 135 140 145 ate ggt agt ttc cag tea tat gtc aat gaa ate aac caa gaa ggc gtt 595 He Gly Ser Phe Gln Ser Tyr Val Asn Glu He Asn Gln Glu Gly Val 150 155 160 165 aat gaa cat ggt gtg gtg gta gta cgc atg tet ggt ggc ggt gca gt 643 Asn Glu His Gly Val Thr Val Val Arg Arg Met Ser Gly Gly Gly Wing 170 175 180 atg ttt atg gag ggc ggc aac tgc ate acc tat tcc ctg tat gca ccg 691 Met Phe Met Glu Gly Gly Asn Cys He Thr Tyr Ser Leu Tyr Ala Pro 185 190 195 10 gaa tet etc gtt ggt gt ttg age tat gag cag tcc tat gaa tat ttg 739 Glu Ser Leu Val Wing Gly Leu Ser Tyr Glu Gln Ser Tyr Glu Tyr Leu 200 205 210 gat cgt tgg gtg att gct gcg ctg aag here falls gat gtt gac gct tgg 787 Asp Arg Trp Val He Ala Wing Leu Lys Thr His Asp Val Asp Wing Trp 215 220 225 tac gtg ect ate aat gac ate acc tcc acc ggc gga aaa ate ggt ggc 835 Tyr Val Pro He Asn Asp He Thr Ser Thr Gly Gly Lys He Gly Gly 230 235 240 245 gct gca cag aaa cgt cgc agt ggc gca gtc etc falls drops gtg acc atg 883 Ala Ala Gln Lys Arg Arg Ser Gly Ala Val Leu His His Val Thr Met 250 255 260 15 tcc tat gac ate gat gcg gac atg atg acc cag gtg ttg cgc att gga 931 Ser Tyr Asp He Asp Wing Asp Met Met Thr Gln Val Leu Arg He Gly 265 270 275 aag gtg aag att tc gac aag ggt ctt cgc age gca aag aag cgc gtt 979 Lys Val Lys He Ser Asp Lys Gly Leu Arg Ser Wing Lys Lys Arg Val 280 285 290 gat ect cgc cgc cca g aca ggt gca tea cgt gag ca ate ate gac 1027 Asp Pro Leu Arg Arg Gln Thr Gly Wing Ser Arg Glu Gln He He Asp 295 300 305 acc ata tct ac ttc agt gct agg tac ggc gcg caa gaa gta gag 1075 Thr Leu Lys Ser Thr Phe Ser Wing Arg Tyr Gly Wing Gln Glu Val Glu 310 315 320 325 20 etc age gat gaa gat tcc gcg gca gcc falls gac cta gta aaa acc aaa 1123 Leu Ser Asp Glu Asp Phe Ala Ala Gly His Asp Leu Val Lys Thr Lys 330 335 340 tac gcc acc gag gag tgg act aag cga gtt caá tagtttctat ggatctgcac 1176 Tyr Ala Thr Glu Glu Trp Thr Lys Arg Val Gln 345 350 aag 1179 < 210 > 186 < 211 > 352 < 212 > PRT < 213 > Corynebacterium glutamicum 25 AGIÉÉ ^^^^ k ^^ j, < 400 > 186 Met Asn Asn His Phe Glu Leu Lys Val Pro Gly Gly Lys Leu Val Val 1 5 10 15 Val Asp Val Thr Thr Asp Leu Asp Ser He Wing Asp Val Lys He Ser 20 25 30 Gly Asp Phe Phe Leu Glu Pro Asp Glu Wing Phe Phe Ala Leu Gly Arg 35 40 45 Ala Leu Gln Gly Ala Ser Val Gly Asp Asn Thr Asp Arg Leu Gln Ala • 50 55 60 Lys Leu Asp Ala Ala Leu Ala Glu Tyr Asp Asp Val Glu Leu His Gly 65 70 75 80 Phe Be Thr Wing Asp He Wing Leu Wing Val Arg Arg Wing Val Thr Gly 85 90 95 Wing Gln Asp Phe Thr Asp Tyr Glu Trp Glu He Leu His Pro Gly Val 100 105 110 Leu Pro Thr Pro Leu Asn Val Ala Leu Asp Glu Leu Leu Leu Asp Gln 115 120 125 Val Wing Gly Gln Arg Gly Pro Thr Met Arg He Trp Asp Trp Asp 130 135 140 Asp Arg Wing Thr Val He Gly Ser Phe Gln Ser Tyr Val Asn Glu He 10 145 150 155 160 Asn Gln Glu Gly Val Asn Glu His Gly Val Thr Val Val Arg Arg Met 165 170 175 Ser Gly Gly Gly Wing Met Phe Met Glu Gly Gly ^ B Asn Cys He Thr Tyr 180 185 190 Ser Leu Tyr Ala Pro Glu Ser Leu Val Ala Gly Leu Ser Tyr Glu Gln 1 95 200 205 Ser Tyr Glu Tyr Leu Asp Arg Trp Val He Wing Wing Leu Lys Thr His 210 215 220 Asp Val Asp Wing Trp Tyr Val Pro He Asn Asp He Thr Ser Thr Gly 225 230 235 240 Gly Lys He Gly Gly Wing Ala Gln Lys Arg Arg Ser Gly Wing Val Leu 15 245 250 255 His His Val Thr Met Ser Tyr Asp He Asp Wing Asp Met Met Met Thr Gln 260 265 270 Val Leu Arg He Gly Lys Val Lys He Ser Asp Lys Gly Leu Arg Ser 275 280 285 Wing Lys Lys Arg Val Asp Pro Leu Arg Arg Gln Thr Gly Wing Ser Arg 290 295 300 Glu Gln He He Asp Thr Leu Lys Ser Thr Phe Ser Wing Arg Tyr Gly • 305 310 315 320 Wing Gln Glu Val Glu Leu Ser Asp Glu Asp Phe Ala Ala Gly His Asp 325 330 335 Leu Val Lys Thr Lys Tyr Ala Thr Glu Glu Trp Thr Lys Arg Val Gln 20 340 345 350 < 210 > 187 < 211 > 876 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (853) < 223 > RXS01746 25 < 400 > 187 . - ^ * Í.Í. :Go?... aaaccgccac tcccctttca ctggggagtg gcggttttgt cgtttcatgc atgeagtgtg 60 tgaettatca accttgttag ggctagggtg gatatetate atg act gca cca aga 115 Met Thr Wing Pro Arg 1 5 gat ect ttt ttc ccc gca gat ctt tet ate cgc gcg tet gca gag ccc 163 Asp Pro Phe Phe Pro Wing Asp Leu Ser He Arg Wing Being Wing Glu Pro 10 15 20 att gaa att cag cgg ttg ggt ttg ate cat gat gag gcc tgg gat 211 • He Glu He Gln Arg Leu Gly Leu He Asp Tyr Gln Glu Wing Trp Asp 25 30 35 tat ca gca gag ctt gct acc cgt agg gct aat gat gaa ate ect gat 259 Tyr Gln Wing Glu Leu Wing Thr Arg Arg Wing Asn Asp Glu He Pro Asp 40 45 50 cag ctg ctt att ttg gag drops ccg tcg gtg tat acc gca ggt aag cgc 307 Gln Leu He Leu Glu His Pro Ser Val Tyr Thr Wing Gly Lys Arg 55 60 65 ccg gag acc gat ctt ccc acc aac gga ctg ccg gtg ate aat gct 355 Thr Gln Pro Glu Asp Leu Pro Thr Asn Gly Leu Pro Val He Asn Wing 70 75 80 85 gat cgt ggt ggt cgc ate acg tgg cat ggt ect ggc caa ttg gtg ate 403 10 Asp Arg Gly Gly Arg He Thr Trp His Gly Pro Gly Gln Leu Val He 90 95 100 tat ccg ate ate aaa tta gcc gat ccg ate gat gtg gtt gat tac gta 451 Tyr Pro • He He Lys Leu Wing Asp Pro He Asp Val Val Asp Tyr Val 105 110 115 aga cgc etc gag gaa gcg etc ate ca gtt gtc ggc gat atg ggt gtt 499 Arg Arg Leu Glu Glu Ala Leu He Gln Val Val Gly Asp Met Gly Val 120 125 130 gcc ggc ggg ggg cgc att gat ggg cgt tcg ggt gtg tgg gtg cca gct 547 Wing Gly Wing Gly Arg He Asp Gly Arg Ser Gly Val Trp Val Pro Wing 135 140 145 cat gat ggt tgg gtg gac age aag gtt gcg gcc ate ggc att cga ata 595 15 His Asp Gly Trp Val Asp Ser Lys Val Wing Wing He Gly He Arg He 150 155 160 165 act cgt ggt gtt gca atg fall ggt gtg gcc ate aac tgc aac aac acg 643 Thr Arg Gly Val Ala Met His Gly Val Ala He Asn Cys Asn Asn Thr 170 175 180 ttg gat ttc tat gag falls att att ccg tgt ggc att gct gat gca ggc 691 Leu Asp Phe Tyr Glu His He He Pro Cys Gly He Wing Asp Wing Gly 185 190 195 • ttg age here etc tcg agg gaa ctg aaa agg gac gtt tea gtt gag gaa 739 Leu Ser Thr Leu Ser Arg Glu Leu Lys Arg Asp Val Ser Val Glu Glu 200 205 210 tta gtc gag cca tcg ate cgc gca ttg gat gat gct ttg gct ggt cgg 787 20 Leu Val Glu Pro Be He Arg Ala Leu Asp Asp Ala Leu Ala Gly Arg 215 220 225 ctg gtt gtt tet gat cat tet tcc ggc age gcg ccc gac cca act aag 835 Leu Val Val Ser Asp His Ser Phe Gly Ser Ala Pro Asp Pro Thr Lys 230 235 240 245 aat etc ect aaa cgg ggg tagtacgagg aattttgtcg gtg 876 Asn Leu Pro Lys Arg Gly 250 < 210 > 188 < 211 > 251 < 212 > PRT 25 < 213 > Corynebacterium glutamicum < 400 > 188 Met Thr Ala Pro Arg Asp Pro Phe Phe Pro Wing Asp Leu Ser He Arg 1 5 10 15 Wing Wing Wing Glu Pro He Glu He Gln Arg Leu Gly Leu He Asp Tyr 20 25 30 Gln Glu Wing Trp Asp Tyr Gln Wing Glu Leu Wing Thr Arg Arg Wing Asn 35 40 45 Asp Glu He Pro Asp Gln Leu Leu He Leu Glu His Pro Ser Val Tyr 50 55 60 Thr Wing Gly Lys Arg Thr Gln Pro Glu Asp Leu Pro Thr Asn Gly Leu 65 70 75 80 Pro Val He Asn Wing Asp Arg Gly Gly Arg He Thr Trp His Gly Pro 85 90 95 Gly Gln Leu Val He Tyr Pro He He Lys Leu Wing Asp Pro He Asp 100 105 110 Val Val Asp Tyr Val Arg Arg Leu Glu Glu Ala Leu He Gln Val Val 115 120 125 Gly Asp Met Gly Val Wing Gly Wing Gly Arg He Asp Gly Arg Ser Gly 130 135 140 Val Trp Val Pro Ala His Asp Gly Trp Val Asp Ser Lys Val Ala Wing 145 150 155 160 He Gly He Arg He Thr Arg Gly Val Ala Met His Gly Val Ala He 165 170 175 Asn Cys Asn Asn Thr Leu Asp Phe Tyr Glu His He He Pro Cys Gly 180 185 190 He Wing Asp Wing Gly Leu Ser Thr Leu Ser Arg Glu Leu Lys Arg Asp 195 200 205 Val Ser Val Glu Val Glu Leu Val Glu Pro Ser He Arg Ala Leu Asp Asp 210 215 220 Ala Leu Ala Gly Arg Leu Val Val Ser Asp His Ser Phe Gly Ser Ala 225 230 235 240 Pro Asp Pro Thr Lys Asn Leu Pro Lys Arg Gly 245 250 < 210 > 189 < 211 > 1167 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1144) < 223 > RXS01747 < 400 > 189 cgaagtagag ccgattgcag aateggcgga atgagaegtc gaaaagegtt taagctttcc 60 ctaaaaatat cactaactcg aaagatgtaa ggttgcattt gtg act ate gca ect 115 Val Thr He Ala Pro 1 5 gaa gga cga cga cga cga cgc cgc gtc gaa gct cga aac tea gaa acc ccg 163 Glu Gly Arg Arg Leu Leu Arg Val Glu Ala Arg Asn Ser Glu Thr Pro 10 15 20 att gag acg aag ect cga tgg att aga aac cag gtc aaa aac gga ect 211 He Glu Thr Lys Pro Arg Trp He Arg Asn Gln Val Lys Asn Gly Pro 25 30 35 gag tat cag gat atg aag gaa cgt gtc gct ggc gca tea cta falls act 259 Glu Tyr Gln Asp Met Lys Glu Arg Val Wing Gly Ala Ser Leu His Thr 40 45 50 gtg tgt cag gag gct ggc tgt ect aat ate cat gag tgt tgg gaa tcc 307 Val Cys Gln Glu Wing Gly Cys Pro Asn He His Glu Cys Trp Glu Ser 55 60 65 cgt gag gca acc ttc etc att ggt ggc gcc aac tgc tet cgc cgc tgt 355 Arg Glu Wing Thr Phe Leu He Gly Gly Wing Asn Cys Ser Arg Arg Cys 70 75 80 85 gat ttc tgc atg ate aac tcg gct cgc ect gag cca etc gac cgc ggt 403 • Asp Phe Cys Met He Asn Ser Wing Arg Pro Glu Pro Leu Asp Arg Gl and 90 95 100 gag cca ctg cgt gtc gct gag tet gtt cgt gag atg cag ctg aat tac 451 Glu Pro Leu Arg Val Wing Glu Ser Val Arg Glu Met Gln Leu Asn Tyr 105 110 115 tcc acc ate acc ggt gtt acc cgt gat gat ctg gat gat gaa ggc gca 499 Be Thr He Thr Gly Val Thr Arg Asp Asp Leu Asp Asp Glu Gly Wing 120 125 130 tgg ctg tac tea gaa gtg gtt cgt aag ate drops gag ctg aac cca drops 547 Trp Leu Tyr Ser Glu Val Val Arg Lys He His Glu Leu Asn Pro His 135 140 145 10 acc ggt gtg gaa aac ctg gtg ect gat ttc tcc ggc aag aag gat ctg 595 Thr Gly Val Glu Asn Leu Val Pro Asp Phe Ser Gly Lys Lys Asp Leu 150 155 160 165 ctg cag gaa gtt ttt gaa tcc cgc cca gag gtt ttc gct falls aac gtg 643 • Leu Gln Glu Val Phe Glu Ser Arg Pro Glu Val Phe Ala His Asn Val 170 175 180 gaa act gtg cca cgt att ttc aag cgc att cgc cca gca ttc cgc tac 691 Glu Thr Val Pro Arg He Phe Lys Arg He Arg Pro Wing Phe Arg Tyr 185 190 195 gag cgt tea ctt gat gtg ate cgt cag gct cgc gat ttc ggt ctg gtg 739 Glu Arg Ser Leu Asp Val He A rg Gln Ala Arg Asp Phe Gly Leu Val 200 205 210 15 acc aag tct aa ctg ttg ggc atg ggt gaa acc aag gaa ate 787 Thr Lys Ser Asn Leu He Leu Gly Met Gly Glu Thlu Lys Glu Glu He 215 220 225 acc gag gcg ctg cag gat ctg falls gac gct ggc tgt gac ate ate acc 835 Thr Glu Wing Leu Gln Asp Leu His Asp Wing Gly Cys Asp He He Thr 230 235 240 245 tc ctg cctt cctt cctt gctt ect ttg ctc ctc gag cgt 883 He Thr Gln Tyr Leu Arg Pro Gly Pro Leu Phe His Pro He Glu Arg 250 255 260 tgg gtg aag ect gag gag ttc etc. gag drops gct gat gct gca aag gaa 931 Trp Val Lys Pro Glu Glu Phe Leu Glu His Wing Asp Ala Ala Lys Glu 265 270 275 20 atg ggc ttc gct gct gtt atg tcc ggc cca ttg gtt cg tcc tet tac 979 Met Gly Phe Ala Ala Val Met Ser Gly Pro Leu Val Arg Ser Ser Tyr 280 285 290 cgt gca ggc cgt ctg tac gcg cag gcc atg gag ttc cgt ggc gag gaa 1027 Arg Wing Gly Arg Leu Tyr Wing Gln Wing Met Glu Phe Arg Gly Glu Glu 295 300 305 ate cca gca drops etc gcg falls ctg aag gat act tcc gga gga tcc acc 1075 He Pro Wing His Leu Wing His Leu Lys Asp Thr Ser Gly Gly Ser Thr 310 315 320 325 gcc cag gaa gca tet here ctt ctg gag cgt tac ggt gct tcc gaa gac 1123 Wing Glr. Glu Ala Ser Thr Leu Leu Glu Arg Tyr Gly Ala Ser Glu Asp 330 335 340 25 acc cca gtg gtg tcc ttc aac taac [ecc? (aa gttttttaac cc | C 1167 ui ti ^^ te | Thr Pro Val Val Ser Phe Asn 345 < 210 > 190 < 211 > 348 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 190 Val Thr He Ala Pro Glu Gly Arg Arg Leu Leu Arg Val Glu Ala Arg 1. 5 10 15 Asn Ser Glu Thr Pro He Glu Thr Lys Pro Arg Trp He Arg Asn Gln 20 25 30 Val Lys Asn Gly Pro Glu Tyr Gln Asp Met Lys Glu Arg Val Wing Gly 35 40 45 Wing Ser Leu His Thr Val Cys Gln Glu Wing Gly Cys Pro Asn He His 50 55 60 Glu Cys Trp Glu Ser Arg Glu Wing Thr Phe Leu He Gly Gly Wing Asn 65 70 75 80 Cys Ser Arg Arg Cys Asp Phe Cys Met He Asn Ser Ala Arg Pro Glu 10 85 90 95 Pro Leu Asp Arg Gly Glu Pro Leu Arg Val Wing Glu Ser Val Arg Glu 100 105 110 Met Gln Leu Asn Tyr Ser Thr He Thr Gly Val Thr Arg Asp Asp Leu • 115 120 125 Asp Asp Glu Gly Wing Trp Leu Tyr Ser Glu Val Val Arg Lys He His 130 135 140 Glu Leu Asn Pro His Thr Gly Val Glu Asn Leu Val Pro Asp Phe Ser 145 150 155 160 Gly Lys Lys Asp Leu Leu Gln Glu Val Phe Glu Ser Arg Pro Glu Val 165 170 175 Phe Ala His Asn Val Glu Thr Val Pro Arg He Phe Lys Arg He Arg 15 180 185 190 Pro Wing Phe Arg Tyr Glu Arg Ser Leu Asp Val He Arg Gln Wing Arg 195 200 205 Asp Phe Gly Leu Val Thr Lys Ser Asn Leu He Leu Gly Met Gly Glu 210 215 220 Thr Lys Glu Glu He Thr Glu Wing Leu Gln Asp Leu His Asp Wing Gly 225 230 235 240 Cys Asp He He Thr He Thr Gln Tyr Leu Arg Pro Gly Pro Leu Phe • 245 250 255 His Pro He Glu Arg Trp Val Lys Pro Glu Glu Phe Leu Glu His Wing 260 265 270 Asp Ala Ala Lys Glu Met Gly Phe Ala Ala Val Met Ser Gly Pro Leu 20 275 280 285 Val Arg Ser Ser Tyr Arg Wing Gly Arg Leu Tyr Wing Gln Wing Met Glu 290 295 300 Phe Arg Gly Glu Glu He Pro Wing His Leu Wing His Leu Lys Asp Thr 305 310 315 320 Ser Gly Gly Ser Thr Wing Gln Glu Ala Ser Thr Leu Leu Glu Arg Tyr 325 330 335 Gly Wing Ser Glu Asp Thr Pro Val Val Ser Phe Asn 340 345 < 210 > 191 < 211 > 903 25 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (880) < 223 > RXC01748 < 400 > 191 • atcaccaaat igtggicggt-tt tgcgtiegaaa agegtgetet ttctacaiect tttacaggt 60 cattttcgcg igtttcctcac aatcgiceta't tgttaagtac atg gca gac gcg aaa 115 Met Ala Asp Ala Lys 1 5 aag cag gcg gat aaa gcc gcc aag aag cag gta aga gca gcc aag aag 163 Lys Gln Wing Asp Lys Wing Wing Lys Lys Gln Val Arg Wing Wing Lys Lys 10 15 20 gca cag cgc aag gag act cgc tea ca at tgg cag gtc ttc aac atg 211 Wing Gln Arg Lys Glu Thr Arg Ser Gln Met Trp Gln Val Phe Asn Met 25 30 35 cac cgc aag cag gat aag gct ctt att ccg ctt ctg ttg etc gct att 259 Gln Arg Lys Gln Asp Lys Ala Leu He Pro Leu Leu Leu Leu Ala He 10 40 45 50 ctt ggt ate ccg ctg gtc ctt ttc etc ate ggt ttg att tgg ggt ggt 307 Leu Gly He Pro Leu Val Leu Phe Leu He Gly Leu He Trp Gly Gly 55 60 65 • cag tgg tgg atg ctt ccg ate ggc att gct gca ggt gtt gta gct gca 355 Gln Trp Met Leu Pro He Gly He Ala Ala Gly Val Val Ala Ala 70 75 80 85 atg ttt att ttc acc cgt cgc gtt gag cgt gac gtg tac aag cgc gcc 403 Met Phe He Phe Thr Arg Arg Val Glu Arg Asp Val Tyr Lys Arg Wing 90 95 100 gaa ggt cag cag ggt gct gct ggt tgg gct gtg gag aac etc cgc tet 451 Glu Gly Gln Gln Gly Wing Wing Gly Trp Wing Val Glu Asn Leu Arg Ser 15 105 110 115 ggc gtg ggc atg acc gtg cgc acc aag gct acc gct gg acc gtg 499 Gly Val Gly Met Thr Trp Arg Thr Lys Thr Ala Val Wing Val Thr Thr 120 125 130 cag atg gat gca gtg falls cgc gtc att ggt ctg tgt ggt gtt gtg ctg 547 Gln Met Asp Ala Val His Arg Val He Gly Leu Cys Gly Val Val Leu 135 140 145 gtc ggc gag ggc tcc ect falls cgc ctg aag cca atg ctt gcg cag caa 595 Val Gly Glu Gly Ser Pro His Arg Leu Lys Pro Met Leu Ala Gln Gln 150 155 160 165 aag aag cgc ctg aac cgc gtg gca ect ggt gtt cca gtg tat gaa ate 643 Lys Lys Arg Leu Asn Arg Val Wing Pro Gly Val Pro Val Tyr Glu He 20 170 175 180 ate acg ggc aac ggc gaa ggc cag acc ect ate gcg aag ctg cag cgt 691 He Thr Gly Asn Gly Glu Gly Gln Thr Pro He Wing Lys Leu Gln Arg 185 190 195 gaa ctg gtc aag ctg ect cgc aac tac aag aag aac gac gtc gct gcc 739 Glu Leu Val Lys Leu Pro Arg Asn Tyr Lys Lys Asn Asp Val Wing Wing 200 205 210 ctg gcc gct cgc att gag gct atg gac aat gtc gga aac gct ect ggc 787 Leu Ala Ala Arg He Glu Ala Met Asp Asn Val Gly Asn Ala Pro Gly 215 220 225 gga tet ttg ect aag ggt cca ttg cca aag ggc gca age atg tcc ggt 835 Gly Ser Leu Pro Lys Gly Pro Leu Pro Lys Gly Wing Ser Met Gly 25 230 235 240 245 atg aac cgc cgc gct cgc cga cag gct gaa cgc aag ggc gag gct Met Asn Arg Arg Ala Arg Arg Gln Ala Glu Arg Lys Gly Glu Ala 250 255 260 taaagccttt tcgctttcgc gtc 903 < 210 > 192 < 211 > 260 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 192 Met Ala Asp Ala Lys Lys Gln Ala Asp Lys Ala Ala Lys Lys Gln Val 1 5 10 15 Arg Ala Ala Lys Ala Gln Arg Lys Glu Thr Arg Ser Gln Met Trp 20 25 30 Gln Val Phe Asn Met Gln Arg Lys Gln Asp Lys Ala Leu He Pro Leu 35 40 45 Leu Leu Leu Ala He Leu Gly He Pro Leu Val Leu Phe Leu He Gly 50 55 60 Leu He Trp Gly Gly Gln Trp Met Leu Pro He Gly He Ala Ala 10 65 70 75 80 Gly Val Val Wing Wing Met Phe He Phe Thr Arg Arg Val Glu Arg Asp 85 90 95 Val Tyr Lys Arg Wing Glu Gly Gln Gln Gly Wing Wing Gly Trp Wing Val • 100 105 110 Glu Asn Leu Arg Ser Gly Val Gly Met Thr Trp Arg Thr Lys Thr Wing 115 120 125 Val Wing Val Thr Thr Gln Met Asp Wing Val His Arg Val He Gly Leu 130 135 140 Cys Gly Val Val Leu Val Gly Glu Pro Gly Ser Pro Arg Leu Lys Pro 145 150 155 160 Met Leu Ala Gln Gln Lys Lys Arg Leu Asn Arg Val Wing Pro Gly Val 15 165 170 175 Pro Val Tyr Glu He He Thr Gly Asn Gly Glu Gly Gln Thr Pro He 180 185 190 Wing Lys Leu Gln Arg Glu Leu Val Lys Leu Pro Arg Asn Tyr Lys Lys 195 2 00 205 Asn Asp Val Ala Ala Ala Ala Ala Arg He Glu Ala Met Asp Asn Val 210 215 220 Gly Asn Ala Pro Gly Gly Ser Leu Pro Lys Gly Pro Leu Pro Lys Gly • 225 230 235 240 Wing Ser Met Ser Gly Met Asn Arg Arg Ala Arg Arg Gln Ala Glu Arg 245 250 255 Lys Gly Glu Wing 20 260 < 210 > 193 < 211 > 936 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (913) < 223 > RXC00354 25 < 400 > 193 ggcttgtcgg taaggctgca gggtagcggg agtttccttc agattggaag ttctttaatt 60 ttctcgatta tgtacctcat ttacgcgtaa agtttggggc atg gga aag tta ctt 115 Met Gly Lys Leu Leu 1 5 ttc gta gac ate ggt ggc here ctg ctg gat tac tea aat gaa gtt ccg 163 Phe Val Asp He Gly Gly Thr Leu Leu Asp Tyr Ser Asn Glu Val Pro 10 15 20 cgt tcg gcc gtt gac gcg ate cgt aag gca cgc gcc aaa gga falls cgc 211 Arg Ser Ala Val Asp Ala He Arg Lys Ala Arg Ala Lys Gly His Arg 25 30 35 gtg tac ttg age tet ggt cga age age gct gag gtg act tet cag ttg 259 Val Tyr Leu Ser Ser Gly Arg Ser Wing Glu Val Thr Ser Gln Leu 40 45 50 tgg gat ate gga gtg gat ggc etc att ggc gca aat ggt gga tat gtg 307 Trp Asp He Gly Val Asp Gly Leu He Gly Wing Asn Gly Gly Tyr Val 55 60 65 gaa age gca cag gag tet gtg ttc falls cgc cgt ttg tcg ggt gag gag 355 Glu Ser Wing Gln Glu Ser Val Phe His Arg Arg Leu Ser Gly Glu Glu 70 75 80 85 acc cgc falls att gtg gag tgg etc tac aac cgt ggt ttg gag ttt tat 403 Thr Arg His He Val Val Glu Trp Leu Tyr Asn Arg Gly Leu Glu Phe Tyr 90 95 100 etc gag tcc aac aac ggt ttg tat gca age cgt ggt ttc cgt gag gct 451 Leu Glu Ser Asn Asn Gly Leu Tyr Ala Ser Arg Gly Phe Arg Glu Ala 105 110 115 tet aag cca gtg ctg tet cgc ctt tcg gag aag acc gac gtg here gtc 499 Ser Lys Pro Val Leu Ser Arg Leu Ser Glu Lys Thr Asp Val Thr Val 120 125 130 gat age atg tac ccg gat atg ttc tgg ggc gcg age ctt gat cgt gac 547 Asp Ser Met Tyr Pro Asp Met Phe Trp Gly Ala Ser Leu Asp Arg Asp 135 140 145 gat gtg aac aag ate agt tac ate ttc aat tet cag gaa gat ttg gac 595 Asp Val Asn Lys He Ser Tyr He Phe Asn Ser Gln Glu Asp Leu Asp 150 155 160 165 gca gcg cgt gag gcg ttc ect aac ctg gag falls acc acg tgg ggt ggt 643 Wing Wing Arg Glu Wing Phe Pro Asn Leu Glu His Thr Thr Trp Gly Gly 170 175 180 cag acg ggt gcg ttg ttc ggc acg ate ggt gtg tet gtc aac aag aag 691 Gln Thr Gly Ala Leu Phe Gly Thr He Gly Val Ser Val Asn Lys Lys 185 190 195 ate ggc gtg gat cgc ctg ctg ctg aag tac ctg aac gca gat cgc gca aac 739 He Gly Val Asp Arg Leu Leu Lys Tyr Leu Asn Wing Asp Arg Wing Asn 200 205 210 acc att gcg tcc gcc gac age gat gag gat etc tcc ct ttt gag gcg 787 Thr He Wing Phe Gly Asp Ser Asp Glu Asp Leu Ser Leu Phe Glu Wing 215 220 225 age gct tac ggc gtc gcg atg ggc gag gcc acc gaa tcg etc aag gct 835 Ser Wing Tyr Gly Val Wing Met Gly Glu Wing Thr Glu Ser Leu Lys Wing 230 235 240 245 gct gct gac ctg gtc acg gat gct gtt ggg cag gac ggc ttg cgc aat 883 Wing Wing Asp Leu Val Thr Asp Wing Val Gly Gln Asp Gly Leu Arg Asn 250 255 260 gcg ttt tta aag ctt gag ctt ate gac gcc tgaccccatc aaagaaette 933 Wing Phe Leu Lys Leu Glu Leu He Asp Wing 265 270 cca 936 ^^ i < 210 > 194 < 211 > 271 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 194 Met Gly Lys Leu Leu Phe Val Asp He Gly Gly Thr Leu Leu Asp Tyr 1 5 10 15 • Ser Asn Glu Val Pro Arg Ser Wing Val Asp Wing He Arg Lys Wing Arg 20 25 30 Wing Lys Gly His Arg Val Tyr Leu Ser Being Gly Arg Being Glu Wing 35 40 45 Val Thr Being Gln Leu Trp Asp He Gly Val Asp Gly Leu He Gly Wing 50 55 60 Asn Gly Gly Tyr Val Glu Ser Wing Gln Glu Ser Val Phe His Arg Arg 65 70 75 80 Leu Ser Gly Glu Glu Thr Arg His He Val Glu Trp Leu Tyr Asn Arg 85 90 95 Gly Leu Glu Phe Tyr Leu Glu Ser Asn Asn Gly Leu Tyr Wing Ser Arg 100 105 110 10 Gly Phe Arg Glu Wing Ser Lys Pro Val Leu Ser Arg Leu Ser Glu Lys 115 120 125 Thr Asp Val Thr Val Asp Ser Met Tyr Pro Asp Met Phe Trp Gly Wing • 130 135 140 Ser Leu Asp Arg Asp Asp Val Asn Lys He Ser Tyr He Phe Asn Ser 145 150 155 160 Gln Glu Asp Leu Asp Ala Ala Arg Glu Ala Phe Pro Asn Leu Glu His 165 170 175 Thr Thr Trp Gly Gly Gln Thr Gly Ala Leu Phe Gly Thr He Gly Val 180 185 190 Ser Val Asn Lys Lys He Gly Val Asp Arg Leu Leu Lys Tyr Leu Asn 19 5 200 205 15 Wing Asp Arg Wing Asn Thr He Wing Wing Phe Gly Asp Being Asp Glu Asp Leu 210 215 220 Being Leu Phe Glu Wing Being Wing Tyr Gly Val Wing Met Gly Glu Wing Thr 225 230 235 240 Glu Ser Leu Lys Wing Wing Wing Asp Leu Val Thr Asp Wing Val Gly Gln 245 '250 255 Asp Gly Leu Arg Asn Wing Phe Leu Lys Leu Glu Leu He Asp Wing 260 265 270 • < 210 > 195 < 211 > 1740 < 212 > DNA 20 < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1717) < 223 > RXC01749 < 400 > 195 ggtttttgcg tgctctggtt tagggactgg ttttgggaac gtgcccagtt ccacatcaaa 60 taacgctgag gtcgtactta atccatgaga tcatgaatgg gtg age ttc ctt gta 115 Val Ser Phe Leu Val 1 5 25 gaa aat caa tta etc gcg ttg gtt gtc ate atg acg gtc gga cta ttg 163 | . .A ^. .A.Ja.A, * .. s _, _ ^ aa &_ ^ Glu Asn Gln Leu Leu Ala Leu Val Val He Met Thr Val Gly Leu Leu 10 15 20 etc ggc cgc ate aaa att ttc ggg ttc cgt etc ggc gtc gcc gct gta 211 Leu Gly Arg He Lys He Phe Gly Phe Arg Leu Gly Val Wing Wing Val 25 30 35 ctg ttt gta gta gta tta gcg cta tc ct gtc ct gtc gtc ct gtc gtc gtc tc ccg gtc 259 Leu Phe Val Gly Leu Ala Leu Ser Thr He Glu Pro Asp He Ser Val 40 45 50 cca tcc etc att tac gtg gtt gga ctg tcg ctt ttt gtc tac acg ate 307 Pro Ser Leu He Tyr Val Val Gly Leu Ser Leu Phe Val Tyr Thr He 55 60 65 ggt ctg gaa gcc ggc ect gga ttttcc ttttcc aacccc ttcccc aattgg aaaaaa aacccc aacctt ggggtt 355 Gly Leu Glu Wing Gly Pro Gly Phe Phe Thr Being Met Lys Thr Thr Gly 70 75 80 85 ctc aac aac aac cca gtcc gcccccc ggcccc aattee aattee ggcccc aacccc aaccgg ggccaa 403 Leu Arg Asn Asn Ala Leu Thr Leu Gly Ala He He Ala Ala Thr Thr Ala 90 95 100 etc gca tgg gca ect here gtt ttg aac ate gat gcc gcc tcc ggc 451 Leu Wing Trp Wing Leu He Thr Val Leu Asn He Asp Wing Wing Ser Gly 105 110 115 gcc ggc atg etc acc ggc gcg etc acc aac acc cca gcc atg gcc gca 499 Wing Gly Met Leu Thr Gly Ala Leu Thr Asn Thr Pro Wing Ala Wing Wing 120 125 130 gtt gtt gac gca ctt ect tcg ctt ate gac gac acc ggc cag ctt fall 547 Val Val Asp Ala Leu Pro Ser Leu He Asp Asp Thr Gly Gln Leu His 135 140 145 etc gcc gag ctg ccc gtc gtc gtc tat tcc ttg gca tac ccc etc 595 Leu He Wing Glu Leu Pro Val Val Wing Tyr Ser Leu Wing Tyr Pro Leu 150 155 160 165 ggt gtg etc ate gtt att etc tcc ate gcc ate ttc age tet gtg ttc 643 Gly Val Leu He Val He Leu Ser He Wing He Phe Ser Ser Val Phe 170 175 180 aaa gtc gac falls aac aaa gaa gcc gaa gaa gcg ggc gtt gcg gtc cag 691 Lys Val Asp His Asn Lys Gl u Wing Glu Glu Wing Gly Val Wing Val Gln 185 190 195 gaa etc aaa ggc cgc cgc ate cgc gtc gtc acc gtc gat cct cc ccc gcc 739 Glu Leu Lys Gly Arg Arg He Arg Val Thr Val Wing Asp Leu Pro Wing 200 205 210 ctg gag aac ate cca gag ctg etc aac etc falls gtc att gtg tcc cga 787 Leu Glu Asn He Pro Glu Leu Leu Asn Leu His Val He Val Ser Arg 215 220 225 gtg gaga cga gac ggt gag cata tcc ate ccg ctt tat ggc gaa cae gca 835 Val Glu Arg Asp Gly Glu Gln Phe He has Pro Leu Tyr Gly Glu His Wing 230 235 240 245 cgc ate ggc gat gtc tta here gtg gtg ggt gcc gat gaa gaa etc aac 883 Arg He Gly Asp Val Leu Thr Val Val Gly Wing Asp Glu Glu Leu Asn 250 255 260 cgc gcg gaa aaa gcc ate ggt gaa etc att gac ggc gac ccc tac age 931 Arg Ala Glu Lys Ala He Gly Glu Leu He Asp Gly Asp Pro Tyr Ser 265 270 275 aat gtg gaa ctt gat tac cga cgc ate ttc gtc tea aac gca gc gc 979 Asn Val Glu Leu Asp Tyr Arg Arg He Phe Val Ser Asn Thr Ala Val 280 285 290 gtg ggc act ccc cta tcc aag etc cag cca ctg ttt aaa gac atg ctg 1027 Val Gly Thr Pro Leu Ser Lys Leu Gln Pro Leu Phe Lys Asp Met Leu 295 300 305 atc cc cc ccgc gcc gcc gcc gac gc gc gc gcc tcc gacc 1075 IJA ^ A ^ tt-? j ^ He Thr Arg He Arg Arg Gly Asp Thr Asp Leu Val Wing Ser Ser Asp 310 315 320 325 atg act ttg cag etc ggt gac cgt gtc cgc gtt gtc gca cca gca gaa 1123 Met Thr Leu Gln Leu Gly Asp Arg Val Arg Val Val Wing Pro Wing Glu 330 335 340 aaa etc cgc gaa gca acc tca gtc etc gcc tcc tac aag aaa etc 1171 Lys Leu Arg Glu Wing Thr Gln Leu Leu Gly Asp Ser Tyr Lys Lys Leu 345 350 355 • tcc gat ttc aac ctg etc cca etc gct gcc ggc etc atg ate ggt gtg 1219 Being Asp Phe Asn Leu Leu Pro Leu Wing Wing Gly Leu Met He Gly Val 360 365 370 ctt gtc ggc atg gtg gag ttc cca cta cca ggt gga age tcc ctg aaa 1267 Leu Val Gly Met Val Glu Phe Pro Leu Pro Gly Gly Ser Ser Leu Lys 375 380 385 ctg ggt aac gca ggt gga ccg cta gtt gtt gcg ctg ctg etc ggc atg 1315 Leu Gly Asn Wing Gly Gly Pro Leu Val Val Wing Leu Leu Leu Gly Met 390 395 400 405 ate aat cgc here ggc aag ttc gtc tgg ca a ate ccc tac g gca aac 1363 He Asn Arg Thr Gly Lys Phe Val Trp Gln He Pro Tyr Gly Wing Asn 410 415 420 gc ate here cta ttt ttg gct gcc ate ggt 1411 10 ctt gcc ctt cgc ca ct g g Leu Ala Leu Arg Gln Leu Gly He Thr Leu Phe Leu Wing Wing He Gly 425 430 435 acc gcg ggc gca gga gt gt gt gt gtc gtc ate age gac ccc ca a tea 1459 • Thr Be Wing Gly Wing Gly Phe Arg Be Wing Be Asp Pro Gln Ser 440 445 450 etc acc ate ate ggc ttc ggt gcg ctg etc act ttg ttc ate tcc ate 1507 Leu Thr He He Gly Phe Gly Wing Leu Leu Thr Leu Phe He Ser He 455 460 465 acg gtg ctg ttc gtt ggc falls aaa ctg atg aaa ate ccc ttc ggt gaa 1555 Thr Val Leu Phe Val Gly His Lys Leu Met Lys He Pro Phe Gly Glu 470 475 480 485 15 acc gct ggc ate gcc gct gctt acg ca g ac cct gctg ctg agt 1603 Thr Wing Gly He Leu Wing Gly Thr Gln Thr His Pro Wing Val Leu Ser 490 495 500 tat gtg tea gat gcc tcc cgc aac gag etc ect gcc atg ggt tat acc 1651 Tyr Val Ser Asp Wing Ser Arg Asn Glu Leu Pro Wing Met Gly Tyr Thr 505 510 515 tet gtg tat ccg ctg gcg atg ate gca aag ate ctg gcc gcc caa acg 1699 Ser Val Tyr Pro Leu Wing Met He Wing Lys He Leu Wing Wing Gln Thr 520 525 530 ttg ttg ttc cta ctt ate tagcattgac ceett: aagcg ce? G 1740 Leu Leu Phe Leu Leu He 535 20 < 210 > 196 < 211 > 539 < 212 > PRT < 213 > C irynebactenum gl .utamicum < 400 > 196 Val Ser Phe Leu Val Glu Asn Gln Leu Leu Ala Leu Val Val He Met 1 5 10 15 Thr Val Gly Leu Leu Leu Gly Arg He Lys He Phe Gly Phe Arg Leu 20 25 30 Gly Val Ala Ala Val Leu Phe Val Gly Leu Ala Leu Ser Thr He Glu 25 35 40 45 ^ Pro Asp He Ser Val Pro Ser Leu He Tyr Val Val Gly Leu Ser Leu 50 55 60 Phe Val Tyr Thr He Gly Leu Glu Wing Gly Pro Gly Phe Phe Thr Ser 65 70 75 80 Met Lys Thr Thr Gly Leu Arg Asn Asn Wing Leu Thr Leu Gly Wing 85 90 95 He Wing Thr Thr Wing Leu Wing Trp Wing Leu He Thr Val Leu Asn He 100 105 110 • Asp Wing Wing Ser Gly Wing Gly Met Leu Thr Gly Wing Leu Thr Asn Thr 115 120 125 Pro Wing Met Ala Ala Val Val Asp Ala Ala Pro Pro Leu He Asp Asp 130 135 140 Thr Gly Gln Leu His Leu He Ala Glu Leu Pro Val Val Ala Tyr Ser 145 150 155 160 Leu Ala Tyr Pro Leu Gly Val Leu He Val He Leu Ser He Wing He 165 170 175 Phe Ser Val Phe Lys Val Asp His Asn Lys Glu Wing Glu Glu Wing 180 185 190 Gly Val Wing Val Gln Glu Leu Lys Gly Arg Arg He Arg Val Thr Val 195 200 205 10 Wing Asp Leu Pro Wing Leu Glu Asn He Pro Glu Leu Leu Asn Leu His 210 215 220 Val He Val Ser Arg Val Glu Arg Asp Gly Gllu Gln Phe He Pro Leu • 225 230 235 240 Tyr Gly Glu His Wing Arg He Gly Asp Val Leu Thr Val Val Gly Wing 245 250 255 Asp Glu Glu Leu Asn Arg Wing Glu Lys Wing He Gly Glu Leu He Asp 260 265 270 Gly Asp Pro Tyr Ser Asn Val Glu Leu Asp Tyr Arg Arg He Phe Val 275 280 285 Ser Asn Thr Wing Val Val Gly Thr Pro Leu Ser Lys Leu Gln Pro Leu 290 295 300 15 Phe Lys Asp Met Leu He Thr Arg He Arg Arg Gly Asp Thr Asp Leu 305 310 315 320 Val Wing Being Ser Asp Met Thr Leu Gln Leu Gly Asp Arg Val Arg Val 325 330 335 Val Wing Pro Wing Glu Lys Leu Arg Glu Wing Thr Gln Leu Leu Gly Asp 340 345 350 Ser Tyr Lys Lys Leu Ser Asp Phe Asn Leu Leu Pro Leu Wing Wing Gly 355 360 365 • Leu Met He Gly Val Leu Val Gly Met Val Glu Phe Pro Leu Pro Gly 370 375 380 Gly Be Ser Leu Lys Leu Gly Asn Wing Gly Gly Pro Leu Val Val Wing 385 390 395 400 20 Leu Leu Leu Gly Met He Asn Arg Thr Gly Lys Phe Val Trp Gln He 405 410 415 Pro Tyr Gly Wing Asn Leu Wing Leu Arg Gln Leu Gly He Thr Leu Phe 420 425 430 Leu Wing Wing He Gly Thr Ser Wing Gly Wing Gly Phe Arg Be Wing He 435 440 445 Be Asp Pro Gln Be Leu Thr He He Gly Phe Gly Wing Leu Leu Thr 450 455 460 Leu Phe He Be He Thr Val Leu Phe Val Gly His Lys Leu Met Lys 465 470 475 480 He Pro Phe Gly Glu Thr Wing Gly He Leu Wing Gly Thr Gln Thr His 485 490 495 25 Pro Wing Val Leu Ser Tyr Val Ser Asp Wing Being Arg Asn Glu Leu Pro 500 505 510 Wing Met Gly Tyr Thr Ser Val Tyr Pro Leu Wing Met He Wing Lys He 515 520 525 Leu Ala Ala Gln Thr Leu Leu Phe Leu Leu He 530 535 < 210 > 197 < 211 > 1023 • < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1000) < 223 > RXA02268 < 400 > 197 tga; atcgttg < gtgcttcg; ag ttgggattgt tatgtgggga gacgtcgata; agcaaaacac 60 ttgccgagcg < aagccggcc tacggcgct; a gtgtgagcac atg tcc cag gaa aat 115 Met Ser Gln Glu Asn 10 1 5 tet ggt ttg ttc aag cgc gcg att here cgt ggg gtg gct aag gtg cgc 163 Be Gly Leu Phe Lys Arg Wing He Thr Arg Gly Val Wing Lys Val Arg 10 15 20 cgg aat ccg cgc gag gat ttt gcg gag gaa ttc acc caa gaa etc tac 211 Arg Asn Pro Arg Glu Asp Phe Wing Glu Glu Phe Thr Gln Glu Leu Tyr 25 30 35 gat falls gca here aat ate acc ctg ccc ctg acg gcg cgg ctg aag ccg 259 Asp His Wing Thr Asn He Thr Leu Pro Leu Thr Wing Arg Leu Lys Pro 40 45 50 aat ggg ttt ttc cag gat gat tgg cgg gcg cga cca agt ggt gcg cga 307 Asn Gly Phe Phe Gln Asp Asp Trp Arg Wing Arg Pro Ser Gly Wing Arg 15 55 60 65 ccg tgg ccg ate gtg cta att fall gga tcc ggg gcc age aag ggt tea 355 Pro Trp Pro He Val Leu He His Gly Ser Gly Wing Ser Lys Gly Ser 70 75 80 85 tgg gag gaa atg ggc gct gag ctg cgc age aaa ggt tgg gcc gtg ttt 403 Trp Glu Glu Met Gly Wing Glu Leu Arg Ser Lys Gly Trp Wing Val Phe 90 95 100 gcc ect gac ttt gga acg cgt gcc acc gag cca att gcg gcg tcg gct 451 Wing Pro Asp Phe Gly Thr Arg Wing Thr Glu Pro Wing Wing Wing Wing 105 110 115 gcc ca gt att ggt tat att gat gcc gtt ttg ttg gtg acg ggc gct 499 Wing Gln He Gly Wing Tyr He Asp Wing Val Leu Leu Val Thr Gly Wing 20 120 125 130 gcg cag att gtg ctg gtt ggg cat tcg ca ggc ggt gtc gtg gcg cgg 547 Ala Gln He Val Leu Val Gly His Ser Gln Gly Val Val Ala Arg 135 140 145 tat tgg atg cgc acc tac ggc gga tac atg aag gtc agg cae atg att 595 Tyr Trp Met Arg Thr Tyr Gly Gly Tyr Met Lys Val Arg His Met He 150 155 160 165 tcc ate tet acg cca aat falls gga acg etc atg gga ggc att tta aac 643 Be He Be Thr Pro Asn His Gly Thr Leu Met Gly Gly He Leu Asn 170 175 180 ccg atg acg aag gtg aaa tcg gga gag gga acg ate gaa aag ctg atg 691 Pro Met Thr Lys Val Lys Ser Gly Glu Gly Thr He Glu Lys Leu Met 25 185 190 195 hu »lA? a i **? ** falls aga cta ttc ggg ccc act ggt ttt gaa cag ctg cgc gga falls gac 739 His Arg Leu Phe Gly Pro Thr Gly Phe Glu Gln Leu Arg Gly His Asp 200 205 210 ate ate gag ttt ttg gcc gac ggt ggg gac etc gat cca ggc gtc acc 787 He He Glu Phe Leu Wing Asp Gly Gly Asp Leu Asp Pro Gly Val Thr 215 220 225 tac acc tgc att ggt acc cat ttt gat ect ttc ate cac ect ccg gag 835 Tyr Thr Cys He Gly Thr His Phe Asp Pro Phe He Gln Pro Pro Glu 230 235 240 245 gtg gcc ttt ttg gag gtc aac gag gac gat gat cca aat cga gtc falls 883 Val Wing Phe Leu Glu Val Asn Glu Asp Asp Asp Pro Asn Arg Val His 250 255 260 aat att tgg gtc gaa gat gaa falls ccg cgc gca atg att gcc falls aac 931 Asn He Trp Val Glu Asp Glu His Pro Arg Ala Met He Ala His Asn 265 270 275 gat atg gtg cgc gat ccc agg gtg ate gaa ate gta cgc gca gag etc 979 Asp Met Val Arg Asp Pro Arg Val He Glu He Val Arg Ala Glu Leu 280 285 290 gac cgg gtg gca cgc etc ggc taagttgggg acatggttga cgc 1023 Asp Arg Val Ala Arg Leu Gly 10 295 300 &l t; 210 > 198 • < 211 > 300 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 198 Met Ser Gln Glu Asn Ser Gly Leu Phe Lys Arg Ala He Thr Arg Gly 1 5 10 15 Val Ala Lys Val Arg Arg Asn Pro Arg Glu Asp Phe Wing Glu Glu Phe 20 25 30 Thr Gln Glu Leu Tyr Asp His Wing Thr Asn He Thr Leu Pro Leu Thr 15 35 40 45 Wing Arg Leu Lys Pro Asn Gly Phe Phe Gln Asp Asp Trp Arg Wing Arg 50 55 60 Pro Ser Gly Wing Arg Pro Trp Pro He Val Leu He His Gly Ser Gly 65 70 75 80 Wing Ser Lys Gly Ser Trp Glu Glu Met Gly Wing Glu Leu Arg Ser Lys 85 90 95 Gly Trp Wing Val Phe Wing Pro Asp Phe Gly Thr Arg Wing Thr Glu Pro 100 105 110 Wing Wing Wing Wing Wing Gln He Gly Wing Tyr He Asp Wing Val Leu 115 120 125 Leu Val Thr Gly Wing 20 Wing Gln He Val Leu Val Gly His Ser Gln Gly 130 135 140 Gly Val Val Wing Arg Tyr Trp Met Arg Thr Tyr Gly Tyr Met Lys 145 150 155 160 Val Arg His Met He Ser Ser Thr Pro Asn His Gly Thr Leu Met 165 170 175 Gly Gly He Leu Asn Pro Met Thr Lys Val Lys Ser Gly Glu Gly Thr 180 185 190 He Glu Lys Leu Met His Arg Leu Phe Gly Pro Thr Gly Phe Glu Gln 195 200 205 Leu Arg Gly His Asp He He Glu Phe Leu Wing Asp Gly Gly Asp Leu 210 215 220 Asp Pro Gly Val Thr Tyr Thr Cys He Gly Thr His Phe Asp Pro Phe 25 «- *" - * | ff- > - «-» »225 230 235 240 He Gln Pro Pro Glu Val Wing Phe Leu Glu Val Asn Glu Asp Asp Asp 245 250 255 Pro Asn Arg Val His Asn He Trp Val Glu Asp Glu His Pro Arg Ala 260 265 270 Met He Ala His As Asp Asp Met Val Arg Asp Pro Arg Val He Glu He 275 280 285 Val Arg Ala Glu Leu Asp Arg Val Ala Arg Leu Gly • 290 295 300 <210> 199 < 211> 1095 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (1072) <223> RXA02269 10 < 400 > 199 cgc, aatgatt igccc¡acaa < cg atatggtgcig cg; ateccagg gtg; ateg; aaaa 1begt; acgcgc 60 agaigctcigac iegggtggcac gcctciggct¡a agttggggac atg gtt gac gcc etc 115 • Met Val Asp Ala Leu 1 5 aat gat etc cgc cga gaa etc here aac gcg tta agg tcc gtg tgg aaa 163 Asn Asp Leu Arg Arg Glu Leu Thr Asn Ala Leu Arg Ser Val Trp Lys 10 15 20 aac etc ccc act gat aac gcc ccg cag gcc gat gcc ttg cca gac gat 211 Asn Leu Pro Thr Asp Asn Wing Pro Gln Wing Asp Wing Leu Pro Asp Asp 25 30 35 gta gtg gaa gag att gcg ata aat ttc tac cgt gat ccc aaa aac cgc 259 15 Val Val Glu Glu He Ala He Asn Phe Tyr Arg Asp Pro Lys Asn Arg 40 45 50 ggc aaa etc aac gaa gac aaa here gat tcc tcg atc etc gcg cgc 307 Gly Lys Leu Asn Glu Asp Lys Thr Asp Ser Leu Pro Met Leu Ala Arg 55 60 65 ata cgt tea cgt gga ctt ttt gaa gac gat tgg cgc gcc cgc ccc acc 355 He Arg Ser Arg Gly Leu Phe Glu Asp Asp Trp Arg Ala Arg Pro Thr 70 75 80 85 • gaa gac cgc ccc tgg cca gtg gta tta gtc falls gga act gga tea here 403 Glu Asp Arg Pro Trp Pro Val Val Leu Val His Gly Thr Gly Ser Thr 90 95 100 aaa ggt gat tgg ca gac ttg gga gcc gat cta cgc cgc gac ggc tgg 451 20 Lys Gly Asp Trp Gln Asp Leu Gly Wing Asp Leu Arg Arg Asp Gly Trp 105 110 115 gca gtg ttt gca ccc gaa ttt ggc caca cgc gcc ggt tea gtc gca gc 499 Wing Val Phe Wing Pro Glu Phe Gly Gln Arg Wing Thr Gly Ser Val Wing 120 125 130 gaa tea tcc gca ca gt gc ca att gcc tat ata gta tta gta tta cct gct 547 Glu Ser Wing Gln He Gly Wing Tyr He Asp Thr Val Leu Leu Wing 135 140 145 gga gcc tea gtc aa gtc att gtc gtt ggc falls tcc ca ggc ggc gtg 595 Thr Gly Ala Ser Lys Val He Val Val Gly His Ser Gln Gly Val 150 155 160 165 ttg ctg aga tac tg atg cgt gtt tgg ggt ggt gca tcc aaa gtc aaa 643 25 Leu Leu Arg Tyr Trp Met Arg Val Leu Gly Gly Wing Ser Lys Val Lys 170 175 180 fall atg gtc tcc etc gct gcc ccc aat falls ggc acc acc atg ggc gga 691 His Met Val Ser Leu Ala Val Pro Asn His Gly Thr Met Gly Gly 185 190 195 ate gtc age ccg cta ate cgt aac aat cgt ggc gaa agt gtg gtt aat 739 He Val Ser Pro Leu He Arg Asn Asn Arg Gly Glu Ser Val Val Asn 200 205 210 tet gtc gtt ca t tea tgc ggc gaa gct gga ttt gaa atg ate cgc 787 Ser Val Val Gln Ser Trp Phe Gly Glu Wing Gly Phe Glu Met He Arg 215 220 225 gga falls gac acc ate aac gcc ate aat gaa ggc ggc gat ttg gat cca 835 Gly His Asp Thr He Asn Wing He Asn Glu Gly Gly Asp Leu Asp Pro 230 235 240 245 gac gtg here tat ctg tgc ate gcc acc fall ttt gac acc gtg att cag Asp Val Thr Tyr Leu Cys He Ala Thr His Phe Asp Thr Val He Gln 250 255 260 ccc ect gaa acc tgc ttc cta gag gcc cgg aac ccc gaa gaa etc aag 931 Pro Pro Glu Thr Cys Phe Leu Glu Wing Arg Asn Pro Glu Glu Leu Lys 265 270 275 cgg gtc caa aac ate tgg gtg gaa aac etc gac ccc aat tea gtc gtg 979 Arg Val Gln Asn He Trp Val Glu Asn Leu Asp Pro Asn Ser Val Val 280 285 290 etc falls gaa gca atg ect tac gat ccc cgc gta cgc gca ctg gtc agg 1027 Leu His Glu Ala Met Pro Tyr Asp Pro Arg Val Arg Ala Leu Val Arg 295 300 305 gcg gat ttg age aaa ttg gtg gag att tcc gag act gcg gag aac 1072 Wing Asp Leu Ser Lys Leu Val Glu He Ser Glu Thr Wing Glu Asn 310 315 320 taggggtttt ggtggttgt: c taa 1095 < 210 > 200 < 211 > 324 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 200 Met Val Asp Ala Leu Asn Asp Leu Arg Arg Glu Leu Thr Asn Ala Leu 1 5 10 15 Arg Ser Val Trp Lys Asn Leu Pro Thr Asp Asn Wing Pro Gln Wing Asp 20 25 30 Wing Leu Pro Asp Asp Val Val Glu Glu He Ala He Asn Phe Tyr Arg 35 40 45 Asp Pro Lys Asn Arg Gly Lys Leu Asn Glu Asp Lys Thr Asp Ser Leu 50 55 60 Pro Met Leu Wing Arg He Arg Being Arg Gly Leu Phe Glu Asp Asp Trp 65 70 75 80 Arg Wing Arg Pro Thr Glu Asp Arg Pro Trp Pro Val Val Leu Val His 85 90 95 Gly Thr Gly Ser Thr Lys Gly Asp Trp Gln Asp Leu Gly Wing Asp Leu 100 105 110 Arg Arg Asp Gly Trp Wing Val Phe Wing Pro Glu Phe Gly Gln Arg Wing 115 120 125 Thr Gly Ser Val Wing Glu Be Wing Gln He Gly Wing Tyr He Asp 130 135 140 Thr Val Leu Leu Wing Thr Gly Wing Ser Lys Val He Val Val Gly His 145 150 155 160 Ser Gln Gly Val Leu Leu Arg Tyr Trp Met Arg Val Leu Gly Gly * & AiA kb 165 170 175 Wing Being Lys Val Lys His Met Val Being Leu Wing Val Pro Asn His Gly 180 185 190 Thr Thr Met Gly Gly He Val Ser Pro Leu He Arg Asn Asn Arg Gly 195 200 205 Glu Ser Val Val Asn Ser Val Val Gln Ser Trp Phe Gly Glu Wing Gly 210 215 220 Phe Glu Met He Arg Gly His Asp Thr He Asn Wing He Asn Glu Gly • 225 230 235 240 Gly Asp Leu Asp Pro Asp Val Thr Tyr Leu Cys He Wing Thr His Phe 245 250 255 Asp Thr Val He Gln Pro Pro Glu Thr Cys Phe Leu Glu Ala Arg Asn 260 265 270 Pro Glu Glu Leu Lys Arg Val Gln Asn He Trp Val Glu Asn Leu Asp 275 280 285 Pro Asn Ser Val Val Leu His Glu Ala Pro Pro Tyr Asp Pro Arg Val 290 295 300 Arg Ala Leu Val Arg Ala Asp Leu Ser Lys Leu Val Glu He Ser Glu 305 310 315 320 Thr Ala Glu Asn 10 < 210 > 201 < 211 > 1146 • < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1123) < 223 > RXA01614 < 400 > 201 tgc; 15 aatttcgc; aaacatgagt agtatcgcgg aagtttcacc acgtgaatrat 1ttcagtcgac 60 tcgt; gcacac < oacaccaaca atcgacctal: cgttatacgt atg aat cag atg cag 115 Met Asn Gln Met Gln 1 5 cag tgg aaa cca gac ttc ctg gga gag ggc tac caac aac etc acc ate 163 Gln Trp Lys Pro Asp Phe Leu Gly Glu Gly Tyr Gln Asn Leu Thr He 10 15 20 gag etc ggc gac gac ccg gat aat gaa here gat gtt gtg here acg gtt 211 • Glu Leu Gly Asp Asp Pro Asp Asn Glu Thr Asp Val Val Thr Thr Val 25 30 35 gtg cgc tac aac cca gac aat falls gcg gac gag tet ttt gct gcc cgc 259 Val Arg Tyr Asn Pro Asp Asn His Wing Asp Glu Ser Phe Wing Wing Arg 20 40 45 50 cca gcg ttg ctg tgg gtt drops ggc atg acg gac tac ttc tcc falls act 307 Pro Wing Leu Leu Trp Val His Gly Met Thr Asp Tyr Phe Phe His Thr 55 60 65 gaa tcc gcg gag ttt tcc falls aat gcc gtt ttt gct gtg tac ggc att 355 Glu Phe Wing Glu Phe Phe His Asn Wing Gly Phe Wing Val Tyr Gly He 70 75 80 85 gat ctt aga aaa tgt gga cgc tcc tac cgt cca gga cag cag tgg drops 403 Asp Leu Arg Lys Cys Gly Arg Ser Tyr Arg Pro Gly Gln Gln Trp His 90 95 100 tac acc tet gat ctt gcc cat tac tctc ect gac tta acct gct gcc gcc 451 Tyr Thr Ser Asp Leu Wing His Tyr Phe Pro Asp Leu Thr Wing Wing Ala 25 105 110 115 gag gtc ate tet tcc acc fall ect gag cta gtc ccc gtc gcc cat tcc 499 Glu Val He Ser Ser Thr His Pro Glu Leu Val Pro Val Ala His Ser 120 125 130 act ggt gga etc ate gtt ect ctg tgg atg tcc cag atg cgc here age 547 Thr Gly Gly Leu He Val Pro Leu Trp Met Ser Gln Met Arg Thr Ser 135 140 145 aat cca gct gcc att gag aag att cca gcg ctg gtc etc aac agt ccg 595 Asn Pro Ala Ala He Glu Lys He Pro Ala Leu Val Leu Asn Ser Pro 150 155 160 165 tgg ctg gac atg tat cca cca ctg ttc ate aag ctg ate acc ect 643 Trp Leu Asp Met Met Tyr Pro Pro Leu Phe He Lys Leu He Thr Pro 170 175 180 atg gtg agg gtg ttg ggc aaa cgc tcc ccc here acc ate ate cca ggc 691 Met Val Arg Val Leu Gly Lys Arg Ser Pro Thr He He Pro Gly 185 190 195 gga ggt ttg gga gca tac gga aaa tcg ate cat aag aac ttt tac ggc 739 Gly Gly Leu Gly Wing Tyr Gly Lys Ser He His Lys Asn Phe Tyr Gly 200 205 210 gaa tgg gac ttt gac acc acc ate act ect gta gaa gga cat aaa aag 787 Glu Trp Asp Phe Asp Thr Thr He Lys Pro Val Glu Gly His Lys Lys 10 215 220 225 age ate gga tgg ctt cgg cg gca gtc atg gct ggc ca gca gaa ate cat 835 Ser He Gly Trp Leu Arg Ala Val Met Ala Gly Gln Ala Glu He His 230 235 240 245 • falls gac falls gtg aat gtc gga gtg gac gtg etc acg ctg tgt tea aat 883 His Asp His Val Asn Val Gly Val Asp Val Leu Thr Leu Cys Ser Asn 250 255 260 aag tcc tgg ttg aag tet gaa tac here gag gac acc aac act tea gac 931 Lys Ser Trp Leu Lys Ser Glu Tyr Thr Glu Asp Thr Asn Thr As Asp 265 270 275 gcg gtt ttg gat gtg aaa falls att caá aag tgg gct ect cat ttg age 979 Wing Val Leu Asp Val Lys His He Gln Lys Trp Wing Pro His Leu Ser 15 280 285 290 tcg cca tcg tcc agg gtt gat gtt gag ate ate gac aac gct cgc cae 1027 Ser Pro Ser Ser Arg Val Asp Val Glu He He As Asn Asn Arg His 295 300 305 gat att ttc etc tea agg aaa ccc gcc aga gat gat gcc tet gaa gta 1075 Asp He Phe Leu Ser Arg Lys Pro Ala Arg Asp His Ala Ser Glu Val 310 315 320 325 etc aac aac tgg ctg caa tcg aag ctt tcc age etc aaa cca tet caa 1123 Leu Asn Asn Trp Leu Gln Ser Lys Leu Ser Ser Leu Lys Pro Ser Gln • 330 335 340 taacacccfcg alattatagate tga 1146 20 < 210 > 202 < 211 > 341 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 202 Met Asn Gln Met Gln Gln Trp Lys Pro Asp Phe Leu Gly Glu Gly Tyr 1 5 10 15 Gln Asn Leu Thr He Glu Leu Gly Asp Asp Pro Asp Asn Glu Thr Asp 20 25 30 Val Val Thr Thr Val Val Arg Tyr Asn Pro Asp Asn His Wing Asp Glu 35 40 45 25 Ser Phe Wing Wing Arg Pro Wing Leu Leu Trp Val His Gly Met Thr Asp 50 55 60 Tyr Phe Phe His Thr Glu Phe Wing Glu Phe Phe His Asn Wing Gly Phe 65 70 75 80 Wing Val Tyr Gly He Asp Leu Arg Lys Cys Gly Arg Ser Tyr Arg Pro 85 90 95 Gly Gln Gln Trp His Tyr Thr Ser Asp Leu Ala His Tyr Phe Pro Asp 100 105 110 Leu Thr Ala Ala Ala Glu Val He Ser Ser Thr His Pro Glu Leu Val 115 120 125 Pro Val Ala His Ser Thr Gly Gly Leu He Val Pro Leu Trp Met Ser 130 135 140 Gln Met Arg Thr Ser Asn Pro Wing Wing He Glu Lys He Pro Wing Leu 145 150 155 160 Val Leu Asn Ser Pro Trp Leu Asp Met Met Tyr Pro Pro Leu Phe He 165 170 175 Lys Leu He Thr Pro Met Val Arg Val Leu Gly Lys Arg Ser Pro Thr 180 185 190 Thr He He Pro Gly Gly Gly Leu Gly Wing Tyr Gly Lys Ser He His 195 200 205 Lys Asn Phe Tyr Gly Glu Trp Asp Phe Asp Thr He Lys Pro Val 210 10 215 220 Glu Gly His Lys Lys Ser He Gly Trp Leu Arg Wing Val Met Wing Gly 225 230 235 240 Gln Wing Glu He His His Asp His Val Asn Val Gly Val Asp Val Leu • 245 250 255 Thr Leu Cys Ser Asn Lys Ser Trp Leu Lys Ser Glu Tyr Th r Glu Asp 260 265 270 Thr Asn Thr Ser Asp Wing Val Leu Asp Val Lys His He Gln Lys Trp 275 280 285 Wing Pro His Leu Ser Ser Pro Ser Ser Arg Val Asp Val Glu He He 290 295 300 Asp Asn Wing Arg His Asp He Phe Leu Ser Arg Lys Pro Wing Arg Asp 305 15 310 315 320 His Wing Ser Glu Val Leu Asn Asn Trp Leu Gln Ser Lys Leu Ser Ser 325 330 335 Leu Lys Pro Ser Gln 340 < 210 > 203 < 211 > 630 < 212 > DNA • < 213 > Corynebacterium glutamicum < 220 > 20 < 221 > CDS < 222 > (101) .. (607) < 223 > RXA01983 < 400 > 203 atatcgctgc catggcagcc ttgctgggca acctcaagca cactgaccta gaagagetec 60 ccaccgatta ccaggggtgt cctcccatgt ccgctgcgtt atg gaa ggc tac gga 115 Met Glu Gly Tyr Gly 1 5 ect acc cag ate gaa aag etc tta ect gca tac here cag gtc aac here 163 Pro Thr Gln He Glu Lys Leu Leu Pro Ala Tyr Thr Gln Val Asn Thr 10 15 20 25 gcc ggg aat aat cca gcg acg acg ect gag ca gt cat etc etc ggc gga 211 t, ¡l-i it ». j Wing Gly Asn Asn Pro Wing Thr Thr Pro Glu Gln Asp Leu Leu Gly Gly 25 30 35 gct gca acc tcg ccg gaa aac tac gac cae cag ctg cag tac gca gtc 259 Ala Ala Thr Ser Pro Glu Asn Tyr Asp His Gln Leu Gln Tyr Ala Val 40 45 50 gac gcc agt ccg gtg cat cag aat gcg gca cag gca ccg ccc ttc ctg 307 Asp Ala Ser Pro Val His Gln Asn Ala Ala Gln Ala Pro Pro Phe Leu 55 60 65 ate atg falls ggc act ggt gac cgg atg gtc ect ccg gag cac tcg gct 355 • He Met His Gly Thr Gly Asp Arg Met Val Pro Pro Glu Gln Ser Wing 70 75 80 85 gcg ctg falls cat ctt gtg cag gct ggt cgg cag tcc acc ctg gta 403 Wing Leu His Thr His Leu Val Gln Wing Gly Arg Gln Be Thr Leu Val 90 95 100 etc att gag ggc ttt ggc falls ggt ttc etc aat ccc ggg gaa gtc gcg 451 Leu He Glu Gly Phe Gly His Gly Phe Leu Asn Pro Gly Glu Val Ala 105 110 115 gag ctg ggg cca aac gtt cga cta gac aat ggt cgg etc gag cgg gag 499 Glu Leu Gly Pro Asn Val Arg Leu Asp Asn Gly Arg Leu Glu Arg Glu 120 125 130 10 ect cag here aat ttc age gcg cag cag agt ccg gga aac ccc ttt gaa 547 Pro Gln Thr Asn Phe Ser Wing Gln Gln Ser Pro Gly Asn Pro Phe Glu 135 140 145 cta cag gga ctt gcc gcc gac cat gag atg ate aag cgc ttt ttc acc 595 Leu Gln Gly Leu Ala Wing Asp His Glu Met He Lys Arg Phe Phe Thr 150 155 160 165 ctg falls ctt cgc taagacteta ccttcaccca act 630 Leu His Leu Arg < 210 > 204 < 211 > 169 15 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 2 (34 Met Glu Gly Tyr Gly Pro Thr Gln He Glu Lys Leu Leu Pro Wing Tyr 1 5 10 15 Thr Gln Val Asn Thr Wing Gly Asn Asn Pro Wing Thr Thr Pro Glu Gln 20 25 30 Asp Leu Leu Gly Wing Ala Wing Thr Ser Pro Glu Asn Tyr Asp His Gln • 35 40 45 Leu Gln Tyr Ala Val Asp Ala Pro Pro Val His Gln Asn Ala Ala Gln 50 55 60 20 Ala Pro Pro Phe Leu He Met His Gly Thr Gly Asp Arg Met Val Pro 65 70 75 80 Pro Glu Gln Ser Ala Ala Leu His Thr His Leu Val Gln Ala Gly Arg 85 90 95 Gln Ser Thr Leu Val Leu He Glu Gly Phe Gly His Gly Phe Leu Asn 100 105 110 Pro Gly Glu Val Ala Glu Leu Gly Pro Asn Val Arg Leu Asp Asn Gly 115 120 125 Arg Leu Glu Arg Glu Pro Gln Thr Asn Phe Ser Wing Gln Gln Ser Pro 130 135 140 Gly Asn Pro Phe Glu Leu Gln Gly Leu Wing Wing Asp His Glu Met He 145 150 155 160 25 Lys Arg Phe Phe Thr Leu His Leu Arg 165 <; 210 > 205 < 211 > 1414 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS • < 222 > (101) .. (1414) < 223 > RXN02947 < 400 > 205 gta'tgtticae .acaaigaaece tigcacaacgic cttcaaagta cgtiegaccac igaccaagcgc 60 attattcact ictcacccttc aiggatttaga ct; aaga; aacc atg act gca gca cag 115 Met Thr Wing Ala Gln 1 5 acc aaa ect gac etc acc acc acg gct gga aag ctg tcc gat ctt cgc 163 Thr Lys Pro Asp Leu Thr Thr Thr Wing Gly Lys Leu Ser Asp Leu Arg 10 15 20 tcc cgt ctt gca gaa gct cact gct cca atg ggc gaa gca act gta gaa 211 Ser Arg Leu Ala Glu Ala Gln Ala Pro Met Gly Glu Ala Thr Val Glu 25 30 35 aaa gtg falls gct gct ggc agg aag act gcc cgc gaa cgt ate gag tat 259 • Lys Val His Wing Wing Gly Arg Lys Thr Wing Arg Glu Arg He Glu Tyr 40 45 50 ttg etc gat gag ggc tet ttc gta gag ate gat gct ctt gct cgt fall 307 Leu Leu Asp Glu Gly Ser Phe Val Glu He Asp Ala Leu Wing Arg His 55 60 65 cgt tcc aaag aac ttc ggc ctg gat gcc aag cgt cca gtt act gac ggt 355 Arg Ser Lys Asn Phe Gly Leu Asp Ala Lys Arg Pro Val Thr Asp Gly 70 75 80 85 gtt gtg act ggt tac ggc acc ate gat ggc cgt aag gtc tgt gtg ttc 403 Val Val Thr Gly Tyr Gly Thr He Asp Gly Arg Lys Val Cys Val Phe 90 95 100 ccc cag gac ggc gct gta ttc ggt ggc gct ttg ggt gaa gtt tat ggt 451 Ser Gln Asp Gly Wing Val Phe Gly Gly Wing Leu Gly Glu Val Tyr Gly 105 110 115 gaa aag ate gtt aag gtt atg gat ctt gcg ate aag ggt gtg ect 499 Glu Lys He Val Lys Val Met Asp Leu Ala He Lys Thr Gly Val Pro 120 125 130 • ttg ate ate gaat ggt ggt ggt gcg cgt ate cag gaa ggt gtt 547 Leu He Gly He Asn Glu Gly Ala Gly Ala Arg He Gln Glu Gly Val 135 140 145 gtg tet ctg ggt ctg tac tea cag ate ttc tac cgc aac acc cag gcg 595 Val Ser Leu Gly Leu Tyr Ser Gln He Phe Tyr Arg Asn Thr Gln Wing 150 155 160 165 tet ggc gtt ate cca cag ate tet ttg ate atg ggt gcc tgc gct ggt 643 Ser Gly Val He Pro Gln He Ser Leu He Met Gly Ala Cys Ala Gly 170 175 180 ggt falls gtg tac tcc ect gct ctg act gac ttc ate gtc atg gtg gat 691 Gly His Val Tyr Ser Pro Ala Leu Thr Asp Phe He Val Met Val Asp 185 190 195 cag act tcc aag atg ttt ate acc ggc ect gat gtc ate aag act gtc 739 Gln Thr Ser Lys Met Phe He Thr Gly Pro Asp Val He Lys Thr Val 200 205 210 acc ggt gaa gat gtc acc cag gag gag etc ggt ggc gct fall acc fall 787 Thr Gly Glu Asp Val Thr Gln Glu Glu Leu Gly Gly Ala His Thr His 215 220 225 atg gct acc tcc ggt acc tcc cat tac tet gct tet gat gat tea gat 835 Met Ala Thr Ser Gly Thr Ser His Tyr Ser Ala Ser Asp Asp Ser Asp 230 235 240 245 gct ttg gat tgg gtt cgc gag ctg acc tet tat ctt cca tcc aac aac 883 Wing Leu Asp Trp Val Arg Glu Leu Thr Ser Tyr Leu Pro Ser Asn Asn 250 255 260 cgt gcg gaa act ect cgc cag gag gcc gac ate atg ate ggt tcc ate 931 Arg Ala Glu Thr Pro Arg Gln Glu Wing Asp He Met He Gly Be He 265 270 275 cag gaa aac ate aac gat gtg gat ctg gaa ttg gac acc ate ate ccg 979 Gln Glu Asn He Asn Asp Val Asp Leu Glu Leu Asp Thr He He Pro 280 285 290 gat tcc ccg aac cag ect tat gac atg aag gaa gtt att tcc cgc ate 1027 Asp Ser Pro Asn Gln Pro Tyr Asp Met Lys Glu Val He Ser Arg He 295 300 305 gtc gac gac gcc gag ttc ttc gag ate cag gaa gac tac gca gag aac 1075 Val Asp Asp Wing Glu Phe Phe Glu He Gln Glu Asp Tyr Wing Glu Asn 310 315 320 325 ate ctg tgt ggc ttc gct cgc gtt gag gtc cgt tet gtt ggc ate gtg 1123 He Leu Cys Gly Phe Ala Arg Val Glu Val Arg Ser Val Gly He Val 330 335 340 gct aac cag cca acc cag ttc gct ggc tgc ttg gat att aag gca tet 1171 Wing Asn Gln Pro Thr Gln Phe Wing Gly Cys Leu Asp He Lys Wing Ser 345 350 355 gag aag gct gcc cgt ttc ate cgc acc tgc gat gcc ttc aac ate cca 1219 Glu Lys Wing Wing Arg Phe He Arg Thr Cys Asp Wing Phe Asn He Pro 360 365 370 ate ctt gag ttc gtg gac gtt cca ggc ttc ctg ect ggc acc aac cag 1267 He Leu Glu Phe Val Asp Val Pro Gly Phe Leu Pro Gly Thr Asn Gln 375 380 385 gaa ttc gac ggc ate ate cgc cgc ggc gca aag ctg ctt tac gct tac 1315 Glu Phe Asp Gly He He Arg Arg Gly Ala Lys Leu Leu Tyr Ala Tyr 390 395 400 405 gct gaa gca acc gtc ggc aag ate acc gtc ate acc cgc aag tcc tac 1363 Wing Glu Wing Thr Val Gly Lys He Thr Val He Thr Arg Lys Ser Tyr 410 415 420 ggc gga gcg tac tgc gtg atg ggt tcc aag gat atg ggc gct ggc ctg 1411 Gly Gly Wing Tyr Cys Val Met Gly Ser Lys Asp Met Gly Wing Gly Leu 425 430 435 gta 1414 Val < 210 > 206 < 211 > 438 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 206 Met Thr Wing Wing Gln Thr Lys Pro Asp Leu Thr Thr Thr Wing Gly Lys 1 5 10 15 Leu Ser Asp Leu Arg Ser Arg Leu Wing Glu Wing Gln Wing Pro Met Gly 20 25 30 Glu Wing Thr Val Glu Lys Val His Wing Wing Gly Arg Lys Thr Ala Arg 35 40 45 Glu Arg He Glu Tyr Leu Leu Asp Glu Gly Ser Phe Val Glu He Asp 50 55 60 Wing Leu Wing Arg His Arg Ser Lys Asn Phe Gly Leu Asp Wing Lys Arg 65 70 75 80 Pro Val Thr Asp Gly Val Val Thr Gly Tyr Gly Thr He Asp Gly Arg 85 90 95 Lys Val Cys Val Phe Ser Gln Asp Gly Wing Val Phe Gly Gly Wing Leu 100 105 110 Gly Glu Val Tyr Gly Glu Lys He Val Lys Val Met Asp Leu Wing He 115 120 125 Lys Thr Gly Val Pro Leu He Gly He Asn Glu Gly Wing Gly Wing Arg 130 135 140 He Gln Glu Gly Val Val Ser Leu Gly Leu Tyr Ser Gln He Phe Tyr 145 150 155 160 Arg Asn Thr Gln Wing Ser Gly Val He Pro Gln He Ser Leu He Met 165 170 175 Gly Wing Cys Wing Gly Gly His Val Tyr Ser Pro Ala Leu Thr Asp Phe 180 185 190 He Val Met Val Asp Gln Thr Ser Lys Met Phe He Thr Gly Pro Asp 195 200 205 Val He Lys Thr Val Thr Gly Glu Asp Val Thr Gln Glu Glu Leu Gly 210 215 220 Gly Ala His Thr His Met Wing Thr Ser Gly Thr Ser His Tyr Ser Wing 225 230 235 240 Ser Asp Asp Ser Asp Ala Leu Asp Trp Val Arg Glu Leu Thr Ser Tyr 245 250 255 Leu Pro Ser Asn Asn Arg Ala Glu Thr Pro Arg Gln Glu To Asp He 260 265 270 Met He Gly Ser He Gln Glu Asn He Asn Asp Val Asp Leu Glu Leu 275 280 285 Asp Thr He He Pro Asp Ser Pro Asn Gln Pro Tyr Asp Met Lys Glu 290 295 300 Val He Ser Arg He Val Asp Asp Wing Glu Phe Phe Glu He Gln Glu 305 310 315 320 Asp Tyr Wing Glu Asn He Leu Cys Gly Phe Wing Arg Val Glu Val Arg 325 330 335 Ser Val Gly He Val Wing Asn Gln Pro Thr Gln Phe Wing Gly Cys Leu 340 345 350 Asp He Lys Wing Ser Glu Lys Wing Wing Arg Phe He Arg Thr Cys Asp 355 360 365 Wing Phe Asn He Pro He Leu Glu Phe Val Asp Val Pro Gly Phe Leu 370 375 380 Pro Gly Thr Asn Gln Glu Phe Asp Gly He He Arg Arg Gly Ala Lys 385 390 395 400 Leu Leu Tyr Ala Tyr Ala Glu Ala Thr Val Gly Lys He Thr Val He 405 410 415 Thr Arg Lys Ser Tyr Gly Gly Wing Tyr Cys Val Met Gly Ser Lys Asp 420 425 430 Met Gly Ala Gly Leu Val 435 <; 210 > 207 < 211 > 688 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > ^^ ¿¿j < 221 > CDS < 222 > (101) .. (688¡ <223> FRXA02320 <400> 207 gtatgtti3C iacaaigaaece tigcacaacgic ettcaaagta cgticgaccac, gaccaagcgc 60 attattcact < ctcacccttc a < ggat'ttaga ct; aagaaacc atg act gca gca cag 115 Met Thr Ala Ala Gln 1 5 acc aaa ect gac etc acc acc acct gct gga aag ctg tcc gat ctt cgc 163 Thr Lys Pro Asp Leu Thr Thr Thr Wing Gly Lys Leu Ser Asp Leu Arg 10 15 20 tcc cgt ctt gca gaa gct ca gct cca atg ggc gaa gca act gta gaa 211 Ser Arg Leu Ala Glu Ala Gln Ala Pro Met Gly Glu Ala Thr Val Glu 25 30 35 aaa gtg falls gct gct ggc agg aag act gcc cgc gaa cgt ate gag tat 259 Lys Val His Ala Ala Gly Arg Lys Thr Wing Arg Glu Arg He Glu Tyr 40 45 50 ttg etc gat gag ggc tet ttc gta gag ate gat gct ctt gct cgt fall 307 Leu Leu Asp Glu Gly Ser Phe Val Glu He Asp Ala Leu Ala Arg His 10 55 60 65 cgt tc aag aac ttc ggc ctg gat gcc aag cgt cca gtt act gac ggt 355 Arg Ser Lys Asn Phe Gly Leu Asp Ala Lys Arg Pro Val Thr Asp Gly 70 75 80 85 • gtt gtg act ggt tac ggc acc ate gat ggc cgt aag gtc tgt gtg ttc 403 Val Val Thr Gly Tyr Gly Thr He Asp Gly Arg Lys Val Cys Val Phe 90 95 100 ccc cag gac ggc gct gta ttc ggt ggc gct ttg ggt gaa gtt tat ggt 451 Ser Gln Asp Gly Ala Val Phe Gly Gly Ala Leu Gly Glu Val Tyr Gly 105 110 115 gaa aag ate gtt aag gtt atg gat ctt gcg ate aag acc ggt gtg ect 499 Glu Lys He Val Lys Val Met Asp Leu Ala He Lys Thr Gly Val Pro 15 120 125 130 ttg ate gga ate aat gag ggt gct ggt gcg cgt ate cag gaa ggt gtt 547 Leu He Gly He Asn Glu Gly Ala Gly Ala Arg He Gln Glu Gly Val 135 140 145 gtg tet ctg ggt ctg tac tea cag ate ttc tac cgc aac acc cag gcg 595 Val Ser Leu Gly Leu Tyr Ser Gln He Phe Tyr Arg Asn Thr Gln Wing 150 155 160 165 tet ggc gtt ate cca cag ate tet ttg ate atg ggt gcc tgc gct ggt 643 • Ser Gly Val He Pro Gln He Ser Leu He Met Gly Ala Cys Ala Gly 170 175 180 ggt falls gtg tac tcc ect gct ctg act gac ttc ate gtc atg gtg 688 Gly His Val Tyr Ser Pro Ala Leu Thr Asp Phe He Val Val Val 20 185 190 195 < 210 > 208 < 211 > 196 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 208 Met Thr Wing Wing Gln Thr Lys Pro Asp Leu Thr Thr Thr Wing Gly Lys 1 5 10 15 Leu Ser Asp Leu Arg Ser Arg Leu Wing Glu Wing Gln Wing Pro Met Gly 20 25 30 25 Glu Wing Thr Val Glu Lys Val His Wing Ala Gly Arg Lys Thr Ala Arg & jj. & , _ & jÁia? cA.Ad & j 35 40 45 Glu Arg He Glu Tyr Leu Leu Asp Glu Gly Ser Phe Val Glu He Asp 50 55 60 Wing Leu Wing Arg His Arg Ser Lys Asn Phe Gly Leu Asp Wing Lys Arg 65 70 75 80 Pro Val Thr Asp Gly Val Val Thr Gly Tyr Gly Thr He Asp Gly Arg 85 90 95 Lys Val Cys Val Phe Ser Gln Asp Gly Ala Val Phe Gly Gly Ala Leu 100 105 110 • Gly Glu Val Tyr Gly Glu Lys Val Val Valve Asp Leu Ala 115 115 125 Lys Thr Gly Val Pro Leu He Gly He Asn Glu Gly Wing Gly Wing Arg 130 135 140 He Gln Glu Gly Val Val Ser Leu Gly Leu Tyr Ser Gln He Phe Tyr 145 150 155 160 Arg Asn Thr Gln Wing Ser Gly Val He Pro Gln He Ser Leu He Met 165 170 175 Gly Wing Cys Wing Gly Gly His Val Tyr Ser Pro Wing Leu Thr Asp Phe 180 185 190 He Val Val Val Val 195 195 < 210 > 209 < 211 > 519 • < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (519) < 223 > FRXA02851 15 < 220 > < 221 > misc_feature < 222 > 135 < 223 > n indicates any nucleotide < 220 > < 221 > misc_feature < 222 > 209 < 223 > n indicates any nucleotide < 220 > < 221 > misc_feature 20 < 222 > 215 < 223 > n indicates any nucleotide < 220 > < 221 > misc_feature < 222 > 258 < 223 > n indicates any nucleotide < 220 > < 221 > VARIANT < 222 > 70 < 223 > Xaa = Val, Ala, Asp, or Gly 25 ? ? i.?? ?????????????????????? 220 > < 221 > VARIANT < 222 > 72 < 223 > Xaa = Phe or Leu < 220 > < 221 > VARIANT < 222 > 86 < 223 > Xaa = Cys, Trp, or stop codon < 400 > 209 ect cgc cag aag gcc gac ate atg ate ggt tcc ate cag gaa aac ate 48 Pro Arg Gln Lys Wing Asp He Met He Gly Ser He Gln Glu Asn He 1 5 10 15 aac gat gtg gat ctg gaa ttg gac acc ate ate ccg gat tcc ccg aac 96 Asn Asp Val Asp Leu Glu Leu Asp Thr He He Pro Asp Ser Pro Asn 20 25 30 cag ect tat gac atg aag gaa gtt att tcc cgc ate gtn gac gac gcc 144 Gln Pro Tyr Asp Met Lys Glu Val He Ser Arg He Val Asp Asp Ala 35 40 45 gag ttc ttc gag ate cag gaa gac tac gca gag aac ate ctg tgt ggc 192 Glu Phe Phe Glu He Gln Glu Asp Tyr Ala Glu Asn He Leu Cys Gly 50 55 60 ttc gct cgc gtt gag gne cgt tnt gtt ggc ate gtg gct aac cag cca 240 Phe Ala Arg Val Glu Xaa Arg Xaa Val Gly He Val Wing Asn Gln Pro 65 70 75 80 acc cg tc gct ggc tgn ttg gat att aag gca tet gag aag gct gcc 288 Thr Gln Phe Wing Gly Xaa Leu Asp He Lys Wing Ser Glu Lys Wing Wing 85 90 95 cgt tcc ate cgc acc tgc gat gcc ttc aac ate cca ate ctt gag ttc 336 Arg Phe He Arg Thr Cys Asp Ala Phe Asn He Pro He Leu Glu Phe 100 105 110 gtg gac gtt cca ggc ttc ctg ect ggc acc aac cag gaa ttc gac ggc 384 Val Asp Val Pro Gly Phe Leu Pro Gly Thr Asn Gln Glu Phe Asp Gly 115 120 125 ate ate cgc cgc ggc gca aag ctg ctt tac gct tac gct gaa gca acc 432 He He Arg Arg Gly Ala Lys Leu Leu Tyr Ala Tyr Ala Glu Ala Thr 130 135 140 gtc ggc aag ate acc gtc ate acc cgc aag tcc tac ggc gga gcg tac 480 Val Gly Lys He Thr Val He Thr Arg Lys Ser Tyr Gly Gly Wing Tyr 145 150 155 160 tgc gtg atg ggt tcc aag gat atg ggc gct ggc ctg gta 519 Cys Val Met Gly Ser Lys Asp Met Gly Wing Gly Leu Val 165 170 < 210 > 210 < 211 > 173 < 212 > PRT < 213 > Corynebacterium glutamicum < 220 > < 221 > VARIANT < 222 > 70 < 223 > Xaa = Val, Ala, Asp, or Gly < 220 > < 221 > VARIANT - .t. - -k.jfc. .IftiLri < 222 > 72 < 223 > Xaa Phe or Leu < 220 > < 221 > VARIANT < 222 > 86 < 223 > Xaa = Cys, Trp, or stop codon < 400 > 210 Pro Arg Gln Lys Wing Asp He Met He Gly Be He Gln Glu Asn He 1 5 10 15 Asn Asp Val Asp Leu Glu Leu Asp Thr He He Pro Pro Asp Ser Pro Asn 20 25 30 Gln Pro Tyr Asp Met Lys Glu Val He Ser Arg He Val Asp Asp Ala 35 40 45 Glu Phe Phe Glu He Gln Glu Asp Tyr Ala Glu Asn He Leu Cys Gly 50 55 60 Phe Ala Arg Val Glu Xaa Arg Xaa Val Gly He Val Ala Asn Gln Pro 65 70 75 80 Thr Gln Phe Wing Gly Xaa Leu Asp He Lys Wing Ser Glu Lys Wing Wing 85 90 95 Arg Phe He Arg Thr Cys Asp Wing Phe Asn He Pro He Leu Glu Phe 100 105 110 Val Asp Val Pro Gly Phe Leu Pro Gly Thr Asn Gln Glu Phe Asp Gly 115 120 125 He He Arg Arg Gly Ala Lys Leu Leu Tyr Ala Tyr Ala Glu Ala Thr 130 135 140 Val Gly Lys He Thr Val He Thr Arg Lys Ser Tyr Gly Gly Wing Tyr 145 150 155 160 Cys Val Met Gly Ser Lys Asp Met Gly Wing Gly Leu Val 165 170 < 210 > 211 < 211 > 1752 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1729) < 223 > RXN02321 < 400 > 211 tttaaaaact; acccgcacgc acgcacgaacc tgttcagtga tgtaaatcac tgcggaaata 60 ttgtggacgt 1bacccccgcc taccgctacg atttcaaaac atg acc att tcc tea 115 Met Thr He Ser Ser 1 5 ect ttg att gac gtc gcc aac ctt cca gac ate aac acc act gcc ggc 163 Pro Leu He Asp Val Wing Asn Leu Pro Asp He Asn Thr Thr Wing Gly 10 15 20 aag ate gcc gac ctt aag gct cgc cgc gcg gaa gcc cat ttc ccc atg 211 Lys He Wing Asp Leu Lys Wing Arg Arg Wing Glu Wing His Phe Pro Met 25 30 35 ggt gaa aag gca gag aag gtc falls gct gct gga cgc etc act gcc 259 Gly Glu Lys Wing Val Glu Lys Val His Wing Wing Gly Arg Leu Thr Wing 40 45 50 cgt gag cgc ttg gat tac tta etc gat gag ggc tcc ttc ate gag acc 307 Arg Glu Arg Leu Asp Tyr Leu Leu Asp Glu Gly Ser Phe He Glu Thr 55 60 65 gat cag ctg gct cgc falls cgc acc acc gct tcc tgc ctg ggc gct aag 355 Asp Gln Leu Wing Arg His Arg Thr Thr Wing Phe Cys Leu Gly Wing Lys 70 75 80 85 cgt ect gca acc gac ggt ate gtg acc ggc tgg ggc acc att gat gga 403 Arg Pro Wing Thr Asp Gly He Val Thr Gly Trp Gly Thr He Asp Gly 90 95 100 cgc gaa gtc tgc ate tcc cag gac ggc acc gta tgc ggc gcg 451 Arg Glu Val Cys He Phe Ser Gln Asp Gly Thr Val Phe Gly Gly Ala 105 110 115 ctt ggt gag gtg tac ggc gaa aag atg ate aag ate atg gag ctg gca 499 Leu Gly Glu Val Tyr Gly Glu Lys Met He Lys He Met Glu Leu Ala 120 125 130 ate gac acc ggc cgc cca ttg ate ggt ctt tac gaa ggc gct ggc gct 547 He Asp Thr Gly Arg Pro Leu He Gly Leu Tyr Glu Gly Wing Gly Wing 135 140 145 cgt att cag gac ggc gct gtc tcc ctg gac ttc att tcc cag acc ttc 595 Arg He Gln Asp Gly Wing Val Ser Leu Asp Phe He Ser Gln Thr Phe 150 155 160 165 10 tac ca aac att cag gct tet ggc gtt ate cca cag ate tc gtc ate 643 Tyr Gln Asn He Gln Wing Ser Gly Val He Pro Gln He Ser Val He 170 175 180 atg ggc gca tgt gca ggt ggc aac gct tac ggc cca gct ctg acc gac 691 • Met Gly Wing Cys Wing Gly Gly Asn Wing Tyr Gly Pro Wing Leu Thr Asp 185 190 195 ttc gtg gtc atg gtg gac aag acc tcc aag atg ttc gtt acc ggc cca 739 Phe Val Val Met Val Asp Lys Thr Ser Lys Met Phe Val Thr Gly Pro 200 205 210 gac gtg ate aga acc gtc acc ggc gag gaa ate acc gag gag ctt 787 Asp Val He Lys Thr Val Thr Gly Glu Glu He Thr Gln Glu Glu Leu 215 220 225 15 ggc gga gca ac acc falls atg gtg acc gct ggt aac tcc falls tac acc 835 Gly Gly Wing Thr Thr His Met Val Thr Wing Gly Asn Ser His Tyr Thr 230 235 240 245 gct gcg acc gat gag gaa gca ctg gat tgg gta cag gac ctg gtg tcc 883 Wing Wing Thr Asp Glu Glu Ala Leu Asp Trp Val Gln Asp Leu Val Ser 250 255 260 ttc etc cca tcc aac aat cgc tcc tac gca ccg atg gaa gac tcc gac 931 Phe Leu Pro Ser Asn Asn Arg Ser Tyr Ala Pro Met Glu Asp Phe Asp 265 270 275 • gag gaa ggc ggc gtt gaa gaa aac ate acc gct gac gat ctg aag 979 Glu Glu Glu Gly Gly Val Glu Glu Asn He Thr Wing Asp Asp Leu Lys 280 285 290 20 etc gac gag ate ate cca gat tcc gcg acc gtt ect tac gac gtc cgc 1027 Leu Asp Glu He He Pro Asp Be Wing Thr Val Pro Tyr Asp Val Arg 295 300 305 gat gtc ate gaa tgc etc acc gac gat ggc gaa tac ctg gaa ate cag 1075 Asp Val He Glu Cys Leu Thr Asp Asp Gly Glu Tyr Leu Glu He Gln 310 315 320 325 gca gac cgc gca gaa aac gtt gtt att gca ttc ggc cgc ate gaa ggc 1123 Wing Asp Arg Wing Glu Asn Val Val He Wing Phe Gly Arg He Glu Gly 330 335 340 cag tcc gtt ggc ttt gtt gcc aac cag cca acc cag ttc gct ggc tgc 1171 Gln Ser Val Gly Phe Val Wing Asn Gln Pro Thr Gln Phe Wing Gly Cys 345 350 355 25 ctg gac ate gac tcc tet gag aag gca gct cgc ttc gtc cgc acc tgc 1219 tL? - Leu Asp He Asp Ser Ser Glu Lys Wing Wing Arg Phe Val Arg Thr Cys 360 365 370 gac gcg ttc aac ate cca ate gtc atg ctt gtc gac gtc ccc ggc ttc 1267 Asp Wing Phe Asn He Pro He Val Met Leu Val Asp Val Pro Gly Phe 375 380 385 etc cca ggc gca ggc cag gag tac ggt ggc att ctg cgt cgt ggc gca 1315 Leu Pro Gly Wing Gly Gln Glu Tyr Gly Gly He Leu Arg Arg Gly Wing 390 395 400 405 aag ctg etc tac gca tac ggc gaa gca acc gtt cca aag ate acc gtc 1363 Lys Leu Leu Tyr Wing Tyr Gly Glu Wing Thr Val Pro Lys He Thr Val 410 415 420 acc atg cgt aag gct tac ggc gga gcg tac tgc gtg atg ggt tcc aag 1411 Thr Met Arg Lys Ala Tyr Gly Gly Ala Tyr Cys Val Met Gly Ser Lys 425 430 435 ggc ttg ggc tet gac ate aac ctt gca tgg cca acc gca cag ate gcc 1459 Gly Leu Gly Ser Asp He Asn Leu Wing Trp Pro Thr Ala Gln He Ala 440 445 450 gtc atg ggc gct gct ggc gt gt gga ttc ate tac cgc aag gag etc 1507 Val Met Gly Wing Wing Gly Wing Val Gly Phe He Tyr Arg Lys Glu Leu 455 460 465 10 atg gca gct gat gcc aag ggc et c gat acc gta gct ctg gct aag tcc 1555 Met Wing Wing Asp Wing Lys Gly Leu Asp Thr Val Wing Ala Leu Wing Lys Ser 470 475 480 485 tcc gag cgc gag tat gaa gac drops atg etc aac ccg tac drops gct gca 1603 • Phe Glu Arg Glu Tyr Glu Asp His Met Leu Asn Pro Tyr His Wing Wing 490 495 500 gaa cgt ggc ctg ate gac gcc gtg ate ctg cca age gaa acc cgc gga 1651 Glu Arg Gly Leu He Asp Ala Val He Leu Pro Ser Glu Thr Arg Gly 505 510 515 cag att tc cgc aac ctt cgc ctg etc aag falls aac aac gc act 1600 Gln He Ser Arg Asn Leu Arg Leu Leu Lys His Lys Asn Val Thr Arg 520 525 530 15 ect gct cgc aag falls ggc aac atg cca ctg taaatcggcg aatccataaa 1749 Pro Ala Arg Lys His Gly Asn Met Pro Leu 535 540 ggt 1752 < 210 > 212 < 211 > 543 < 212 > PRT < 213 > Corynebacterium glutamicum • < 400 > 212 Met Thr He Ser Ser Pro Leu He Asp Val Wing Asn Leu Pro Asp He 20 1 5 10 15 Asn Thr Thr Wing Gly Lys He Wing Asp Leu Lys Wing Arg Arg Wing Glu 20 25 30 Wing His Phe Pro Met Gly Glu Lys Wing Val Glu Lys Val His Wing Wing 35 40 45 Gly Arg Leu Thr Wing Arg Glu Arg Leu Asp Tyr Leu Leu Asp Glu Gly 50 55 60 Be Phe He Glu Thr Asp Gln Leu Wing Arg His Arg Thr Thr Wing Phe 65 70 75 80 Cys Leu Gly Wing Lys Arg Pro Wing Thr Asp Gly He Val Thr Gly Trp 85 90 95 Gly Thr He Asp Gly Arg Glu Val Cys He Phe Ser Gln Asp Gly Thr 25 100 105 110 Val Phe Gly Gly Wing Leu Gly Glu Val Tyr Gly Glu Lys Met He Lys 115 120 125 He Met Glu Leu Wing He Asp Thr Gly Arg Pro Leu He Gly Leu Tyr 130 135 140 Glu Gly Wing Gly Wing Arg He Gln Asp Gly Wing Val Ser Leu Asp Phe 145 150 155 160 He Is Gln Thr Phe Tyr Gln Asn He Gln Wing Ser Gly Val He Pro 165 170 175 Gln He Ser Val He Met Gly Wing Cys Wing Gly Gly Asn Wing Tyr Gly 180 185 190 Pro Wing Leu Thr Asp Phe Val Val Met Val Asp Lys Thr Ser Lys Met 195 200 205 Phe Val Thr Gly Pro Asp Val He Lys Thr Val Thr Gly Glu Glu He 210 215 220 Thr Gln Glu Glu Leu Gly Gly Wing Thr Thr His Met Val Thr Ala Gly 225 230 235 240 Asn Ser His Tyr Thr Wing Wing Thr Asp Glu Glu Wing Leu Asp Trp Val 245 250 255 Gln Asp Leu Val Ser Phe Leu Pro Ser Asn Asn Arg Ser Tyr Ala Pro 260 265 270 Met Glu Asp Phe Asp Glu Glu Glu Gly Gly Val Glu Glu Asn He Thr 275 280 285 Wing Asp Asp Leu Lys Leu Asp Glu He He Pro Asp Ser Wing Thr Val 290 295 300 Pro Tyr Asp Val Arg Asp Val He Glu Cys Leu Thr Asp Asp Gly Glu 305 310 315 320 Tyr Leu Glu He Gln Wing Asp Arg Wing Glu Asn Val Val He Wing Phe 325 330 335 Gly Arg He Glu Gly Gln Ser Val Gly Phe Val Wing Asn Gln Pro Thr 340 345 350 Gln Phe Wing Gly Cys Leu Asp He Asp Ser Ser Glu Lys Ala Wing Arg 355 360 365 Phe Val Arg Thr Cys Asp Wing Phe Asn He Pro Val Val Le Leu Val 370 375 380 Asp Val Pro Gly Phe Leu Pro Gly Wing Gly Gln Glu Tyr Gly Gly He 385 390 395 400 Leu Arg Arg Gly Wing Lys Leu Leu Tyr Wing Tyr Gly Glu Wing Thr Val 405 410 415 Pro Lys He Thr Val Thr Met Arg Lys Wing Tyr Gly Gly Wing Tyr Cys 420 425 430 Val Met Gly Ser Lys Gly Leu Gly Ser Asp He Asn Leu Wing Trp Pro 435 440 445 Thr Ala Gln He Ala Val Met Gly Ala Ala jsiy Ala Val Gly Phe He 450 455 460 Tyr Arg Lys Glu Leu Met Wing Wing Asp Wing Lys Gly Leu Asp Thr Val 465 470 475 480 Ala Leu Ala Lys Ser Phe Glu Arg Glu Tyr Glu Asp His Met Leu Asn 485 490 495 Pro Tyr His Wing Wing Glu Arg Gly Leu He Asp Wing Val He Leu Pro 500 505 510 Ser Glu Thr Arg Gly Gln He Ser Arg Asn Leu Arg Leu Leu Lys His 515 520 525 Lys Asn Val Thr Arg Pro Wing Arg Lys His Gly Asn Met Pro Leu 530 535 540 < 210 > 213 < 211 > 467 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (444) < 223 > FRXA02321 < 220 > • < 221 > misc_feature < 222 > 50 < 223 > n indicates any nucleotide < 220 > < 221 > misc_feature < 222 > 51 < 223 > n indicates any nucleotide < 220 > < 221 > VARIANT 10 < 222 > 17 < 223 > Xaa = Val, Ala, Asp, Glu, or Gly < 400 > 213 • gag tac ggt ggc att ctg cgt cgt ggc gca aag ctg etc tac gca tcg 48 Glu Tyr Gly Gly He Leu Arg Arg Gly Wing Lys Leu Leu Tyr Wing Ser 1 5 10 15 gnn gaa gca ccg gtt cca aag ate acc gtc acc atg cgt aag gct tac 96 Xaa Glu Ala Pro Val Pro Lys He Thr Val Thr Met Arg Lys Ala Tyr 20 25 30 ggc gga gcg tac tgc gtg atg ggt tcc aag ggc ttg ggc tet gac ate 144 Gly Gly Wing Tyr Cys Val Met Gly Ser Lys Gly Leu Gly Ser Asp He 15 35 40 45 aac ctt gca tgg cca acc gca cag ate gcc gtc atg ggc gct gct gcc 192 Asn Leu Wing Trp Pro Thr Wing Gln He Wing Val Met Gly Wing Wing Gly 50 55 60 gca gtt gtc tcc atecc cgc aag gag etc atg gcc gct gat gcc aag 240 Wing Val Gly Phe He Tyr Arg Lys Glu Leu Met Wing Wing Asp Wing Lys 65 70 75 80 ggc etc gat acc gta gct ctg gct aag tcc tcc gag cgc gag tat gaa 288 Gly Leu Asp Thr Val Wing Leu Wing Lys Ser Phe Glu Arg Glu Tyr Glu 85 90 95 gac drops atg etc aac ccg tac drops gct gca gaa cgt ggc ctg ate gac 336 Asp His Met Leu Asn Pro Tyr His Wing Wing Glu Arg Gly Leu He Asp 20 100 105 110 gcc gtg ate ctg cca age gaa acc cgc gga cag att tcc cgc aac ctt 384 Ala Val He Leu Pro Ser Glu Thr Arg Gly Gln He Ser Arg Asn Leu 115 120 125 cgc ctg etc aag falls aag aac gtc act cgc ect gct cgc aag cae ggc 432 Arg Leu Leu Lys His Lys Asn Val Thr Arg Pro Wing Arg Lys His Gly 130 135 140 aac atg cca ctg taaatcggcg aatccataaa ggt 467 Asn Met Pro Leu 145 < 210 > 214 25 < 211 > 148 < 212 > PRT < 213 > Corynebacterium glutamicum < 220 > < 221 > VARIANT < 222 > 17 < 223 > Xaa = Val, Ala, Asp, Glu, or Gly <; 400 > 214 • Glu Tyr Gly Gly He Leu Arg Arg Gly Ala Lys Leu Leu Tyr Ala Ser 1 5 10 15 Xaa Glu Ala Pro Val Pro Lys He Thr Val Thr Met Arg Lys Ala Tyr 20 25 30 Gly Gly Ala Tyr Cys Val Met Gly Ser Lys Gly Leu Gly Ser Asp He 35 40 45 Asn Leu Wing Trp Pro Thr Wing Gln He Wing Val Met Gly Wing Wing Gly 50 55 60 Wing Val Gly Phe He Tyr Arg Lys Glu Leu Met Wing Wing Asp Wing Lys 65 70 75 80 Gly Leu Asp Thr Val Ala Leu Ala Lys Ser Phe Glu Arg Glu Tyr Glu 85 90 95 10 Asp His Met Leu Asn Pro Tyr His Wing Wing Glu Arg Gly Leu He Asp 100 105 110 Wing Val He Leu Pro Ser Glu Thr Arg Gly Gln He Ser Arg Asn Leu 115 120 125 Arg Leu Leu Lys His Lys Asn Val Thr Arg Pro Wing Arg Lys His Gly 130 135 140 Asn Met Pro Leu 145 < 210 > 215 < 211 > 514 < 212 > DNA 15 < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (514) < 223 > FRXA02343 < 400 > 215 tttaaaaact; acccgcacgc atgcacgaacc tgttcatgtga tgtaaatcac cgcggaaata 60 ttgtggacgt 1tacccccgcc taccgctacg atttcaaaac atg acc att tcc tea 115 Met Thr He Ser Ser 20 1 5 ect ttg att gac gtc gcc aac ctt cca gac ate aac acc act gcc ggc 163 Pro Leu He Asp Val Wing Asn Leu Pro Asp He Asn Thr Thr Wing Gly 10 15 20 aag ate gcc gac ctt aag gct cgc cgc gcg gaa gcc cat ttc ccc atg 211 Lys He Wing Asp Leu Lys Wing Arg Arg Wing Glu Wing His Phe Pro Met 25 30 35 ggt gaa aag gca gag aag gtc falls gct gct gga cgc etc act gcc 259 Gly Glu Lys Wing Val Glu Lys Val His Wing Wing Gly Arg Leu Thr Wing 40 45 50 cgt gag cgc ttg gat tac tta etc gat gag ggc tcc ttc ate gag acc 307 Arg Glu Arg Leu Asp Tyr Leu Leu Asp Glu Gly Ser Phe He Glu Thr 25 55 60 65 í A í. »To go i ...?.,. 4. gat cag ctg gct cgc falls cgc acc acc gct tcc tgc ctg ggc gct aag 355 Asp Gln Leu Arg Arg His Arg Thr Thr Ala Phe Cys Leu Gly Ala Lys 70 75 80 85 cgt ect gca acc gac ggc ate gtg acc ggc tgg ggc acc att gat gga 403 Arg Pro Wing Thr Asp Gly He Val Thr Gly Trp Gly Thr He Asp Gly 90 95 100 cgc gaa gtc tgc ate tcc cag gac ggc acc gta ttc ggt ggc gcg 451 Arg Glu Val Cys He Phe Ser Gln Asp Gly Thr Val Phe Gly Gly Ala 105 110 115 ctt ggt gag gtg tac ggc gaa aag atg ate aag ate atg gag ctg gca 499 Leu Gly Glu Val Tyr Gly Glu Lys Met He Lys He Met Glu Leu Wing 120 125 130 ate gac acc ggc cgc 514 He Asp Thr Gly Arg 135 < 210 > 216 < 211 > 138 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 216 Met Thr He Ser Ser Pro Leu He Asp Val Ala Asn Leu Pro Asp He 1 5 10 15 Asn Thr Thr Wing Ala Gly Lys He Wing Asp Leu Lys Wing Arg Arg Wing Glu 20 25 30 Wing His Phe Pro Met Gly Glu Lys Wing Val Glu Lys Val His Wing Wing 35 40 45 Gly Arg Leu Thr Wing Arg Glu Arg Leu Asp Tyr Leu Leu Asp Glu Gly 50 55 60 Be Phe He Glu Thr Asp Gln Leu Wing Arg His Arg Thr Thr Wing Phe 65 70 75 80 Cys Leu Gly Wing Lys Arg Pro Wing Thr Asp Gly He Val Thr Gly Trp 85 90 95 Gly Thr He Asp Gly Arg Glu Val Cys He Phe Ser Gln Asp Gly Thr 100 105 110 Val Phe Gly Gly Ala Leu Gly Glu Val Tyr Gly Glu Lys Met He Lys 115 120 125 He Met Glu Leu Ala He Asp Thr Gly Arg 130 135 < 210 > 217 < 211 > 492 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (492) < 223 > FRXA02850 < 220 > < 221 > misc_feature < 222 > 258 < 223 > n indicates any nucleotide < 220 > . ^ _____ J¡__i__ < 221 > misc_feature < 222 > 302 < 223 > n indicates any nucleotide < 220 > < 221 > VARIANT < 222 > 86 < 223 > Xaa = He or Met < 220 > < 221 > VARIANT < 222 > 101 < 223 > Xaa = Val,, Al; a, Asp, < or Gly < 400 > 217 gaa gag ctt ggc gga gca acc acc fall atg gtg acc gct ggt aac tcc 48 Glu Glu Leu Gly Gly Wing Thr Thr His Met Val Thr Wing Gly Asn Ser 1 5 10 15 falls tac acc gct gcg acc gat gag gaa gca ctg gat tgg gta cag gac 96 His Tyr Thr Ala Ala Thr Asp Glu Glu Ala Leu Asp Trp Val Gln Asp 20 25 30 ctg gtg tcc ttc etc cca tcc aac aat cgc tcc tac gca ccg atg gaa 144 Leu Val Ser Phe Leu Pro Ser Asn Asn Arg Ser Tyr Ala Pro Met Glu 35 40 45 gac ttc gac gag gaa gag ggc ggc gtt gaa gaa aac ate acc gct gac 192 Asp Phe Asp Glu Glu Glu Gly Gly Val Glu Glu Asn He Thr Wing Asp 50 55 60 gat ctg aag etc gac gag ate ate cca gat tcc gcg acc gtt ect tac 240 Asp Leu Lys Leu Asp Glu He He Pro Asp Be Wing Thr Val Pro Tyr 65 70 75 80 gac gtc cgc gat gtc atn gaa tgc etc acc gac gat ggc gaa tac ctg 288 Asp Val Arg Asp Val Xaa Glu Cys Leu Thr Asp Asp Gly Glu Tyr Leu 85 90 95 gaa ate cag gca gne cgc gca gaa aac gtt gtt att gca ttc ggc cgc 336 Glu He Gln Ala Xaa Arg Ala Glu Asn Val Val He Ala Phe Gly Arg 100 105 110 ate gaa ggc cag tcc gtt ggc ttt gtt gcc aac cag cca acc cag ttc 384 He Glu Gly Gln Ser Val Gly Phe Val Wing Asn Gln Pro Thr Gln Phe 115 120 125 gct ggc tgc ctg gac ate gac tcc tet gag aag gca gct cgc ttc gtc 432 Ala Gly Cys Leu Asp He Asp Ser Ser Glu Lys Ala Ala Arg Phe Val 130 135 140 cgc acc tgc gac gcg ttc aac ate cca ate gtc atg ctt gtg gac gtc 480 Arg Thr Cys Asp Wing Phe Asn He Pro He Val Val Leu Le Val Asp 145 150 155 160 ccc ggc ttc etc 492 Pro Gly Phe Leu < 210 > 218 < 211 > 164 < 212 > PRT < 213 > Corynebacterium glutamicum < 220 > < 221 > VARIANT < 222 > 86 ^^ i. < 223 > Xaa = He or Met < 220 > < 221 > VARIANT < 222 > 101 < 223 > Xaa = Val, Ala, Asp, or Gly < 400 > 218 Glu Glu Leu Gly Gly Wing Thr Thr His Met Val Thr Wing Gly Asn Ser 1 5 10 15 His Tyr Thr Wing Wing Thr Asp Glu Glu Wing Leu Asp Trp Val Gln Asp 20 25 30 Leu Val Ser Phe Leu Pro Ser Asn Asn Arg Be Tyr Ala Pro Met Glu 35 40 45 Asp Phe Asp Glu Glu Glu Gly Gly Val Glu Glu Asn He Thr Ala Asp 50 55 60 Asp Leu Lys Leu Asp Glu He He Pro Asp Ser Ala Thr Val Pro Tyr 65 70 75 80 Asp Val Arg Asp Val Xaa Glu Cys Leu Thr Asp Asp Gly Glu Tyr Leu 85 90 95 10 Glu He Gln Wing Xaa Arg Wing Glu Asn Val Val He Wing Phe Gly Arg 100 105 110 He Glu Gly Gln Ser Val Gly Phe Val Wing Asn Gln Pro Thr Gln Phe 115 120 125 • Wing Gly Cys Leu Asp He Asp Ser Ser Glu Lys Wing Wing Arg Phe Val 130 135 140 Arg Thr Cys Asp Wing Phe Asn He Pro He Val Val Leu Val Asp Val 145 150 155 160 Pro Gly Phe Leu < 210 > 219 < 211 > 1671 15 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (164Í < 223 > RXA02583 • < 400 > 219 cagttgtcga tgaaccagaa atcggcacag tcggagctca tttgagtcgc cgcattgatg 60 agatttctcg gaagaattag taacggagag ctgacggaag ttg agt aac ac act 115 Leu Ser Asn Thr Thr 20 1 5 act gca gag aag cta gcg gat ctg cgc gca cgc ctg gag att gcc aaa 163 Thr Ala Glu Lys Leu Ala Asp Leu Arg Wing Arg Leu Glu He Wing Lys 10 15 20 gac cca ggt agt gaa cgc gca cgt aaa aag cgc gac gag gag ggc cga 211 Asp Pro Gly Ser Glu Arg Wing Arg Lys Lys Arg Asp Glu Glu Gly Arg 25 30 35 acc ect cgt cag cgt att gat gct ctg ctt gat gcc gga tct ttr 259 Thr Thr Pro Arg Gln Arg He Asp Ala Leu Leu Asp Ala Gly Ser Phe 40 45 50 gtg gag ate ggc gca cta ggc cgt acc ccg gat gaa ccc gat gcg ect 307 Val Glu He Gly Ala Leu Gly Arg Thr Pro Asp Glu Pro Asp Ala Pro 25 55 60 65 ^^ ggrfj iTlíli * '! , T! T tac tc gac ggt gtg gtg act ggt tat ggt cgc ate gat ggt cgc cca 355 Tyr Ser Asp Gly Val Val Thr Gly Tyr Gly Arg He Asp Gly Arg Pro 70 75 80 85 gtg gcc ate tac gcc cat gac aag acc gtt tac ggt ggt tcc gtg ggc 403 Val Ala He Tyr Ala His Asp Lys Thr Val Tyr Gly Gly Ser Val Gly 90 95 100 atg act ttc gga cgt aaa gtc age gaa gtc atg gac atg gct ate cgc 451 Met Thr Phe Gly Arg Lys Val Ser Glu Val Met Asp Met Wing He Arg 105 110 115 • att ggt tgc cca gtt ate ggt att cag gat ggc gga gcc cgc att 499 He Gly Cys Pro Val He Gly He Gln Asp Ser Gly Gly Ala Arg He 120 125 130 cag gat gcg gtg acc tcc ttg gcg atg tac tea gag ate gcg cgt cgt 547 Gln Asp Wing Val Thr Ser Leu Wing Met Tyr Ser Glu He Wing Arg Arg 135 140 145 cag ctt ccg ctg tet ggc cgc age ect cag att tc ctg atg ggt 595 Gln Leu Pro Leu Ser Gly Arg Ser Pro Gln He Ser Met Met Leu Gly 150 155 160 165 aaa tcg gca ggt ggc gca gtg tat gca ect gtg ac act gac ttt gtt 643 Lys Ser Ala Gly Gly Ala Val Tyr Al a Pro Val Thr Thr Asp Phe Val 10 170 175 180 ate ggc gtt gat ggt gaa here gaa atg tat gtc acc ggc cca gcc gtg 691 He Gly Val Asp Gly Glu Thr Glu Met Tyr Val Thr Gly Pro Ala Val 185 190 195 • ate aag gaa gtc acc ggc gag cag ate act tcc gca gac ggt ggc ggc 739 He Lys Glu Val Thr Gly Glu Gln He Thr Ser Wing Asp Leu Gly Gly 200 205 210 ggt gcg cag atg cag atg caac aac ggc aac att tcc tat ttg gcg tcc tet 787 Gly Wing Gln Gln Met Gln Asn Gly Asn He Ser Tyr Leu Wing Ser Ser 215 220 225 gaa gaa gcc ctg aat atg gtc aag gat ttg etc gac ttc ctg ect 835 Glu Glu Glu Ala Leu Asn Met Val Lys Asp Leu Leu Asp Phe Leu Pro 15 230 235 240 245 ttg acc tgc aat gat cca gcc ect gtg ttt gca gca cca ac ga gat gaa 883 Leu Thr Cys Asn Asp Pro Pro Wing Val Phe Ala Wing Pro Thr Asp Glu 250 255 260 gag ate gcc tac gac gaa gct ctg aac tcg ttc atg ect gac gac act 931 Glu He Wing Tyr Asp Glu Wing Leu Asn Being Phe Met Pro Asp Asp Thr 265 270 275 aac cag ggc tac gac atg cat gac ctg ctg gac aag ctt ttc gac gac 979 Asn Gln Gly Tyr Asp Met His Asp Leu Leu Asp Lys Leu Phe Asp Asp • 280 285 290 gcc aac ctg ctg gaa ate caa gag gag tac gcc ccc aac ctg ate act 1027 Wing Asn Leu Leu Glu He Gln Glu Glu Tyr Ala Pro Asn Leu He Thr 20 295 300 305 acc ttc gcc cgc gtt gat ggc aag gca gtc ggt gtg gtg gcc aac caa 1075 Thr Phe Ala Arg Val Asp Gly Lys Wing Val Gly Val Val Wing Asn Gln 310 315 320 325 cca atg gat aag gca ggc tgc ate gac gct gac gcc gcc gac aag ggc 1123 Pro Met Asp Lys Wing Gly Cys He Asp Wing Asp Wing Wing Asp Lys Gly 330 335 340 gcc cgc ttc ate cgt ate tgc gac gcc tac aac ate ccg ate ate ttc 1171 W arg Phe He Arg He Cys Asp Ala Tyr Asn He Pro He He Phe 345 350 355 gtc gtg gac acc ect ggc tac ctg ect ggc gtg gac ca gag aag gtc 1219 Val Val Asp Thr Pro Gly Tyr Leu Pro Gly Val Asp Gln Glu Lys Val 25 360 365 370 IIM1I lililí nttjfa ^ M ^ JMÉ - ^^^ J ^^^ íMMDUIL Éi ggt ttg att falls cgt ggc gca aag cta gcc ttc gca gtg gtg gaa tcg 1267 Gly Leu He His Arg Gly Ala Lys Leu Ala Phe Ala Val Val Glu Ser 375 380 385 acc gtc ect aag att tcc ttg ate gtg cgc aag gcc tac ggc gga gca 1315 Thr Val Pro Lys He Ser Leu He Val Arg Lys Wing Tyr Gly Gly Wing 390 395 400 405 tat gcc gtg atg ggt tcc aag aac etc acc ggt gac etc aac ttc gca 1363 Tyr Ala Val Met Gly Ser Lys Asn Leu Thr Gly Asp Leu Asn Phe Wing 410 415 420 tgg cca acc gca cag ate gcc gtg atg ggc gca gcc gca gct gtc gtg 1411 Trp Pro Thr Wing Gln He Wing Val Met Gly Wing Wing Wing Wing Val Val 425 430 435 atg ate cag ggc aag cag etc gaa gcc gcc cca ect gag cag cgt gaa 1459 Met He Gln Gly Lys Gln Leu Glu Ala Wing Pro Pro Glu Gln Arg Glu 440 445 450 tac atg aa aaa ctg ttc atc gac tcc tac gat gag aac atc acc age 1507 Tyr Met Lys Lys Leu Phe Met Asp Phe Tyr Asp Glu Asn Met Thr Ser 455 460 465 cca tat gtg gcc gcc gag cgt ggt tac ate gac gcc atg ate gaa ect 1555 Pro Tyr Val Wing Wing Glu Arg Gly Tyr He Asp Wing Met He Glu Pro 10 470 475 480 485 gca gag acc cgt ttg gtg ctt cgc cga gca gtc cgc cag ctg gaa acc 1603 Wing Glu Thr Arg Leu Val Leu Arg Arg Wing Val Arg Gln Leu Glu Thr 490 495 500 • aag gct gga cga gac etc gac aag aag falls acg ate atg ccg atg 1648 Lys Ala Val Arg Asp Leu Asp Lys Lys His Thr He Met Met Pro 505 510 515 taacgtccaa agaattatcc aga 1671 < 210 > 220 < 211 > 516 < 212 > PRT 15 < 213 > Corynebacterium glutamicum < 400 > 220 Leu Ser Asn Thr Thr Thr Wing Glu Lys Leu Wing Asp Leu Arg Wing Arg 1 5 10 15 Leu Glu He Wing Lys Asp Pro Gly Ser Glu Arg Wing Arg Lys Lys Arg 20 25 30 Asp Glu Glu Gly Arg Thr Thr Pro Arg Gln Arg He Asp Ala Leu Leu 35 40 45 • Asp Wing Gly Ser Phe Val Glu He Gly Wing Leu Gly Arg Thr Pro Asp 50 55 60 Glu Pro Asp Wing Pro Tyr Ser Asp Gly Val Val Thr Gly Tyr Gly Arg 20 65 70 75 80 He Asp Gly Arg Pro Val Wing He Tyr Wing His Asp Lys Thr Val Tyr 85 90 95 Gly Gly Ser Val Gly Met Thr Phe Gly Arg Lys Val Ser Glu Val Met 100 105 110 Asp Met Wing He Arg He Gly Cys Pro Val He Gly He Gln Asp Ser 115 120 125 Gly Gly Wing Arg He Gln Asp Wing Val Thr Ser Leu Wing Met Tyr Ser 130 135 140 Glu He Wing Arg Arg Gln Leu Pro Leu Ser Gly Arg Ser Pro Gln He 145 150 155 160 Ser He Met Leu Gly Lys Ser Wing Gly Gly Wing Val Tyr Wing Pro Val 25 165 170 175 Thr Thr Asp Phe Val He Gly Val Asp Gly Glu Thr Glu Met Tyr Val 180 185 190 Thr Gly Pro Wing Val He Lys Glu Val Thr Gly Gllu Gln He Thr Ser 195 200 20 5 Wing Asp Leu Gly Gly Gly Wing Gln Gln Met Gln Asn Gly Asn He Ser 210 215 220 Tyr Leu Wing Ser Glu Glu Glu Wing Leu Asn Met Val Lys Asp Leu 225 230 235 240 Leu Asp Phe Leu Pro Leu Thr Cys Asn Asp Pro Wing Pro Val Phe Wing • 245 250 255 Wing Pro Thr Asp Glu Glu He Wing Tyr Asp Glu Wing Leu Asn Ser Phe 260 265 270 Met Pro Asp Asp Thr Asn Gln Gly Tyr Asp Met His Asp Leu Leu Asp 275 280 285 Lys Leu Phe Asp Asp Wing Asn Leu Leu Glu He Gln Glu Glu Tyr Wing 290 295 300 Pro Asn Leu He Thr Thr Phe Wing Arg Val Asp Gly Lys Wing Val Gly 305 310 315 320 Val Val Wing Asn Gln Pro Met Asp Lys Wing Gly Cys He Asp Ala Asp 325 330 335 10 Wing Wing Asp Lys Gly Wing Arg Phe He Arg He Cys Asp Ala Tyr Asn 340 345 350 He Pro He He Phe Val Val Asp Thr Pro Gly Tyr Leu Pro Gly Val 355 360 365 • Asp Gln Glu Lys Val Gly Leu He His Arg Gly Wing Lys Leu Wing Phe 370 375 380 Wing Val Val Glu Ser Thr Val Pro Lys He Ser Leu He Val Arg Lys 385 390 395 400 Wing Tyr Gly Gly Wing Tyr Wing Val Met Gly Ser Lys Asn Leu Thr Gly 405 410 415 Asp Leu Asn Phe Wing Trp Pro Thr Wing Gln He Wing Val Met Gly Wing 420 425 430 15 Wing Wing Val Val Met He Gln Gly Lys Gln Leu Glu Ala Wing Pro 435 440 445 Pro Glu Gln Arg Glu Tyr Met Lys Lys Leu Phe Met Asp Phe Tyr Asp 450 455 460 Glu Asn Met Thr Ser Pro Tyr Val Wing Wing Glu Arg Gly Tyr He Asp 465 470 475 480 Wing Met He Glu Pro Wing Glu Thr Arg Leu Val Leu Arg Arg Wing Val 485 490 495 Arg Gln Leu Glu Thr Lys Wing Val Arg Asp Leu Asp Lys Lys His Thr • 500 505 510 He Met Pro Met 515 20 < 210 > 221 < 211 > 1635 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1612) < 223 > RXA00870 < 400 > 221 25 caagacggcg atgtcgccgc cgctgttgat accgcagcgc gacttgttca cacagatatt 60 , 1 i .¡.4Í..a __ > jü? m ^^^^^^^^^^^ caacaat-tea iCttCigcag, ag cattt, aagga atttacacac atg tet gaa cca caa 115 Met Ser Glu Pro Gln 1 5 acc ate tcg falls tgg att gac ggc gcg att tcc cca tcc act tcc ggc 163 Thr He Ser His Trp He Asp Gly Wing He Ser Pro Ser Thr Ser Gly 10 15 20 aag ac gct ect gtc tac aat ect gct act ggc cag gtc acc gcc aat 211 Lys Thr Wing Pro Val Tyr Asn Pro Wing Thr Gly Gln Val Thr Wing Asn 25 30 35 gtt gcg ctg gct age cag gaa gag ate gat gcc acc ate gct tet gcc 259 Val Ala Leu Ala Ser Gln Glu Glu He Asp Wing Thr He Wing Wing Wing 40 45 50 acc aag gct aag acg tgg ggc aac ctg tet ate gct aag cgc ca a 307 Thr Lys Wing Wing Lys Thr Trp Gly Asn Leu Ser Wing Lys Arg Gln 55 60 65 gct gtg ctt ttc aac ttc cgt gag ctg ctg aat gct cgc aag ggt gag 355 Wing Val Leu Phe Asn Phe Arg Glu Leu Leu Asn Wing Arg Lys Gly Glu 70 75 80 85 ctg gcg gag ate ate act gca gag cae ggc aag gtc ttg tcc gat gcc 403 Leu Ala Glu He He Thr Ala Glu His Gly Lys Val Leu Ser Asp Wing 90 95 100 atg ggt gaa ate ctg cgc ggc cag gaa gtc gtg gag ctt gct acc ggt 451 Met Gly Glu He Leu Arg Gly Gln Glu Val Val Glu Leu Wing Thr Gly 105 110 115 tcc cca falls ctg ctt aaa ggt gcg ttc aac gag aac gtc tcc acc ggc 499 Phe Pro His Leu Leu Lys Gly Wing Phe Asn Glu Asn Val Ser Thr Gly 120 125 130 att gat gtg tat tcc ttg aag cag cca ctg ggt gtt gtc ggt ate ate 547 He Asp Val Tyr Ser Leu Lys Gln Pro Leu Gly Val Val Gly He He 135 140 145 age ccg ttc aac ttc ect gcg atg gtg ccg atg tgg ttt ttc cca ate 595 Being Pro Phe Asn Phe Pro Wing Met Val Pro Met Trp Phe Phe Pro He 150 155 160 165 gca ate gct gca ggc aac gca gtt att ttg aag ect tea gag aag gat 643 Wing Wing Wing Wing Gly Asn Wing Val He Leu Lys Pro Ser Glu Lys Asp 170 175 180 ect tcg gca gcg ctg tgg atg gct cag ate tgg aag gaa gct ggt ctt 691 Pro Be Wing Wing Leu Trp Met Wing Gln He Trp Lys Glu Wing Gly Leu 185 190 195 cca gac ggc gta ttc aac gtg etc cag ggc gac aag ctg gct gtt gat 739 Pro Asp Gly Val Phe Asn Val Leu Gln Gly Asp Lys Leu Wing Val Asp 200 205 210 ggt ttg ctg aac age ect gat gtc tet gcg att tcc ttc gtg ggt tcc 787 Gly Leu Leu Asn Ser Pro Asp Val Ser Wing Be Ser Phe Val Gly Ser 215 220 225 acc cca ate gca aag tac ate tac gag act tcc gcg aag aac ggc aag 835 Thr Pro He Wing Lys Tyr He Tyr Glu Thr Being Wing Lys Asn Gly Lys 230 235 240 245 cgc gtc cag gcg ttg ggc ggc gcg aag aac falls atg ctg gtg ctg cca 883 Arg Val Gln Ala Leu Gly Gly Ala Lys Asn His Met Leu Val Leu Pro 250 255 260 gat gct gat ctg gat ctg gtt gcc gat cag gca ate aac gca ggt tac 931 Asp Wing Asp Leu Asp Leu Val Wing Asp Gln Wing He Asn Wing Gly Tyr 265 270 275 ggc gct gcc ggt gag cgt tgc atg gct gtt tet gtg gtc ttg gct att 979 Gly Wing Wing Gly Glu Arg Cys Met Wing Val Ser Val Val Leu Wing He 280 285 290 gaa tet gtt gcc gac gag etc att gag aag ate aag gag cgc ate gac 1027 Glu Ser Val Wing Asp Glu Leu He Glu Lys He Lys Glu Arg He Asp 295 300 305 acc ctg cgc ate ggc aac ggt gcc ggc gac gag cag ggc gag ccg falls 1075 Thr Leu Arg He Gly Asn Gly Ala Gly Asp Glu Gln Gly Glu Pro His 310 315 320 325 ctg ggc cta cca ate acc gac gtc falls CGC GAC AAG gtc GCT tet tat 1123 Leu Gly Pro Leu He Thr Asp Val His Arg Asp Lys Val Ala Ser Tyr 330 335 340 • gtc gac tie GCT gag gcc GAC GGC gcc AAG tie tie GTG gac ggg cgt 1171 Val Asp I Ala Glu Ala Asp Gly Ala Lys He He Val Asp Gly Arg 345 350 355 aac tgc gcc gta gac ggg falls gag gag ggc ttc ttc ttc ggc ect acg 1219 Asn Cys Ala Val Asp Gly His Glu Glu Gly Phe Phe Phe Gly Pro Thr 360 365 370 ctt ate gac gac ate cca etc acg tcc cgc gcc tac acc gaa gaa ate 1267 Leu He Asp Asp He Pro Leu Thr Phe Arg Ala Tyr Thr Glu Glu He 375 380 385 ttc ggc ccg gtc etc tet gtc gtt cgt gt c gca aka ttc gac gag gca 1315 Phe Gly Pro Val Leu Ser Val Val Arg Val Ala Ser Phe Asp Glu wing 10 390 395 400 405 att gag ctg ate aac aka ggt gaa ttc ggc aac gga acc gca ate ttc 1363 He Glu Leu He Asn Ser Gly Glu Phe Gly Asn Gly Thr Ala've Phe 410 415 420 • acc aac gat GGT GGA GCG GCA CGC CGC ttc cag cat gag tie gaa GTG 1411 Thr Asn Asp Gly Gly Ala Ala Arg Arg Phe Gln His Glu I Glu Val 425 430435 GGC atg tie GGC tie aac gta cca tie cca GTG ect GTT GCG tac fall 1459 Gly Met've Gly I Asn Val Pro I Pro Val Pro Val Ala Tyr His 440,445,450 aka ttc GGT GGT TGG AAG aac aka etc ttc GGT GAC gcc aag gca tat 1507 Ser Phe Gly Gly Trp Lys Asn Ser Leu Phe Gly Asp Ala Lys Ala Tyr 15 455 460 465 ggc act ca ggt ttt gat ttc ttc acc agg gaa aag gcg ate acc age 1555 Gly Thr Gln Gly Phe Asp Phe Phe Thr Arg Glu Lys Wing He Thr Ser 470 475 480 485 cgt tgg etc gac cca gca acc fall ggt ggc att aac etc ggt tcc cca 1603 Arg Trp Leu Asp Pro Wing Thr His Gly Gly He Asn Leu Gly Phe Pro 490 495 500 cag aac gat taattgaagg agageacagg act 1635 Gln Asn Asp • < 210 > 222 20 < 211 > 504 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 222 Met Ser Glu Pro Gln Thr He Ser His Trp He Asp Gly Wing He Ser 1 5 10 15 Pro Ser Thr Ser Gly Lys Thr Wing Pro Val Tyr Asn Pro Wing Thr Gly 20 25 30 Gln Val Thr Wing Asn Val Wing Ala Leu Wing Gln Glu Glu He Asp Wing 35 40 45 Thr He Wing Wing Wing Thr Lys Wing Wing Lys Thr Trp Gly Asn Leu Ser 25 50 55 60 He Wing Lys Arg Gln Wing Val Leu Phe Asn Phe Arg Glu Leu Leu Asn 65 70 75 80 Wing Arg Lys Gly Glu Leu Wing Glu He He Thr Wing Glu His Gly Lys 85 90 95 Val Leu Ser Asp Wing Met Gly Glu He Leu Arg Gly Gln Glu Val Val 100 105 110 Glu Leu Wing Thr Gly Phe Pro His Leu Leu Lys Gly Wing Phe Asn Glu 115 120 125 Asn Val Ser Thr Gly He Asp Val Tyr Ser Leu Lys Gln Pro Leu Gly • 130 135 140 Val Val Gly He He Ser Pro Phe Asn Phe Pro Wing Met Val Pro Met 145 150 155 160 Trp Phe Phe Pro He Wing Wing Wing Wing Gly Asn Wing Val He Leu Lys 165 170 175 Pro Ser Glu Lys Asp Pro Wing Wing Wing Leu Trp Wing Wing Gln He Trp 180 185 190 Lys Glu Wing Gly Leu Pro Asp Gly Val Phe Asn Val Leu Gln Gly Asp 195 200 205 Lys Leu Ala Val Asp Gly Leu Leu Asn Ser Pro Asp Val Ser Wing He 210 215 220 Ser Phe Val Gly Ser Thr Pro He Wing Lys Tyr He Tyr Glu Thr Ser 10 225 230 235 240 Wing Lys Asn Gly Lys Arg Val Gln Wing Leu Gly Gly Ala Lys Asn His 245 250 255 • Met Leu Val Leu Pro Asp Wing Asp Leu Asp Leu Val Wing Asp Gln Wing 260 265 270 He Asn Wing Gly Tyr Gly Wing Wing Gly Glu Arg Cys Met Wing Val Ser 275 280 285 Val Val Leu Ala He Glu Ser Val Wing Asp Glu Leu He Glu Lys He 290 295 300 Lys Glu Arg He Asp Thr Leu Arg He Gly Asn Gly Wing Gly Asp Glu 305 310 315 320 Gln 15 Gly Glu Pro His Leu Gly Pro Leu He Thr Asp Val His Arg Asp 325 330 335 Lys Val Ala Ser Tyr Val Asp He Wing Glu Wing Asp Gly Wing Lys He 340 345 350 He Val Asp Gly Arg Asn Cys Wing Val Asp Gly His Glu Glu Gly Phe 355 360 365 Phe Phe Gly Pro Thr Leu He Asp Asp He Pro Leu Thr Phe Arg Wing 370 375 380 Tyr Thr Glu Glu He Phe Gly Pro Val Leu Ser Val Val Arg Val Wing 385 390 395 400 Ser Phe Asp Glu Wing He Glu Leu He Asn Ser Gly Glu Phe Gl and Asn 405 410 415 20 Gly Thr Wing He Phe Thr Asn Asp Gly Gly Wing Wing Arg Arg Phe Gln 420 425 430 His Glu He Glu Val Gly Met He Gly He Asn Val Pro Pro Val 435 440 445 Pro Val Wing Tyr His Ser Phe Gly Gly Trp Lys Asn Ser Leu Phe Gly 450 455 460 Asp Wing Lys Wing Tyr Gly Thr Gln Gly Phe Asp Phe Phe Thr Arg Glu 465 470 475 480 Lys Wing He Thr Ser Arg Trp Leu Asp Pro Wing Thr His Gly Gly He 485 490 495 Asn Leu Gly Phe Pro Gln Asn Asp 500 25 - Aiii "< 210 > 223 < 211 > 1305 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1282) < 223 > RXA01260 • < 400 > 223 cta, aacgtgg igctgcatticc ttccaaagtic tctgaticaaa aacigctgaag • ttgcccatac 60 ctttacccat, gaga, agaa, ga ccttcggcat caatggcgaa gtg acc ttc aac tat 115 Val Thr Phe Asn Tyr 1 5 gag gat gct falls aag cgt tcc cgt ggc gtt tcc gac aag ate gtt gga 163 Glu Asp Ala His Lys Arg Ser Arg Gly Val Ser Asp Lys He Val Gly 10 15 20 ggc gtt cat tac ttg atg aag aag aac aag ate ate gaa att cat ggt 211 Gly Val His Tyr Leu Met Lys Lys Asn Lys He He Glu He His Gly 10 25 30 35 ctt gga aac ttc aag gat gct aag act ctt gag gtc acc gac ggt aag 259 Leu Gly Asn Phe Lys Asp Wing Lys Thr Leu Glu Val Thr Asp Gly Lys 40 45 50 • gat gct ggc aag acc ate acc ttt gat gac tgc ate ate gca acc ggt 307 Asp Wing Gly Lys Thr He Thr Phe Asp Asp Cys He He Wing Thr Gly 55 60 65 tcg gta gtc aac acc etc cgt ggc gtt gac ttc tea gag aac gtt gtg 355 Ser Val Val Asn Thr Leu Arg Gly Val Asp Phe Ser Glu Asn Val Val 70 75 80 85 tet ttt gaa gag cag att ctt aac ect gtt gcg cca aag aag gtc 403 Be Phe Glu Glu Gln He Leu Asn Pro Val Wing Pro Lys Lys Met Val 15 90 95 100 att gtt ggt gca ggc gca att gga atg gaa tcc gcc tac gtt ctt ggt 451 He Val Gly Ala Gly Ala He Gly Met Glu Phe Ala Tyr Val Leu Gly 105 110 115 aac tac ggt gta gat gta acc gtc ate gag ttc atg gat cgt gtg ctt 499 Asn Tyr Gly Val Asp Val Thr Val He. Glu Phe Met Asp Arg Val Leu 120 125 130 cca aat gaa gat gct gaa gtc tcc aag gtt att gca aag gcc tac aag 547 Pro Asn Glu Asp Wing Glu Val Ser Lys Val He Wing Lys Wing Tyr Lys 135 140 145 aag atg ggc gtt aag ctt ctt ect ggc cat gca acc act gct gtt cgg 595 Lys Met Gly Val Lys Leu Leu Pro Gly His Wing Thr Thr Wing Val Arg 20 150 155 160 165 gac aac ggt gac ttt gtc gag gtt gat tac cag aag aag ggc tet gac 643 Asp Asn Gly Asp Phe Val Glu Val Asp Tyr Gln Lys Lys Gly Ser Asp 170 175 180 aag here gag act ctt act gtt gat cga gtc atg gtt tcc gtt ggt ttc 691 Lys Thr Glu Thr Leu Thr Val Asp Arg Val Met Val Ser Val Gly Phe 185 190 195 cgt cca cgc gtt gag gga ttt ggt ctt gaa aac act ggc gtt aag etc 739 Arg Pro Arg Val Glu Gly Phe Gly Leu Glu Asn Thr Gly Val Lys Leu 200 205 210 acc gag cgt ggc gca ate gag ate gat gat tac atg cgt acc aac gtc 787 Thr Glu Arg Gly Wing He Glu He Asp Asp Tyr Met Arg Thr Asn Val 25 215 220 225 gat ggc att tac gcc ate ggt gac gtg acc gcc aag ctt cag ctt gct 835 Asp Gly He Tyr Ala He Gly Asp Val Thr Ala Lys Leu Gln Leu Ala 230 235 240 245 falls gtc gca gaa gca cag ggc att gtt gcc gca gag act att gct ggt 883 His Val Ala Glu Ala Gln Gly He Val Ala Ala Glu Thr He Ala Gly 250 255 260 gca gaa act cag act ctt ggt gat tac atg atg atg cca cgt gca acc 931 Wing Glu Thr Gln Thr Leu Gly Asp Tyr Met Met Met Pro Arg Wing Thr 265 270 275 • ttc tgc aac cca cag gtt tet tcc ttt ggt tac acc gaa gag cag gcc 979 Phe Cys Asn Pro Gln Val Being Ser Phe Gly Tyr Thr Glu Glu Gln Wing 280 285 290 aag gag aag tgg cca gat cgt gag ate aag gtt gct tcc tcc cca ttc 1027 Lys Glu Lys Trp Pro Asp Arg Glu He Lys Val Ala Ser Phe Pro Phe 295 300 305 tet gca aac ggt aaa gca gtt ggc ctg gca gaa act gat ggt ttc gca 1075 Ser Wing Asn Gly Lys Wing Val Gly Leu Wing Glu Thr Asp Gly Phe Wing 310 315 320 325 aag ate gtt gct gat gca gaa tt c ggt gag ctg etc ggt gca falls ctg 1123 Lys He Val Wing Asp Wing Glu Phe Gly Glu Leu Leu Gly Wing His Leu 10 330 335 340 gtt gga gca aat gca tea gag etc ate aat gaa ttg gtg ctt gct cag 1171 Val Gly Ala Asn Ala Ser Glu Leu He Asn Glu Leu Val Leu Ala Gln 345 350 355 • aac tgg gat etc acc act gaa gag ate tet cgt age gtc cat att cae 1219 Asn Trp Asp Leu Thr Thr Glu Glu He Ser Arg Ser Val His He His 360 365 370 cca acg cta tet gag gca gtt aag gaa gct gca fall ggt ate tet gga 1267 Pro Thr Leu Ser Glu Ala Val Lys Glu Ala Ala His Gly He Ser Gly 375 380 385 falls at t ate aac ttc tagaatecae ctcgttggcc ctg 1305 His Met He Asn Phe 15 390 < 210 > 224 < 211 > 394 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 224 Val Thr Phe Asn Tyr Glu Asp Ala His Lys Arg Ser Arg Gly Val Ser • 1 5 10 15 Asp Lys He Val Gly Gly Val His Tyr Leu Met Lys Lys Asn Lys He 20 25 30 20 He Glu He His Gly Leu Gly Asn Phe Lys Asp Wing Lys Thr Leu Glu 35 40 45 Val Thr Asp Gly Lys Asp Wing Gly Lys Thr He Thr Phe Asp Asp Cys 50 55 60 He He Wing Thr Gly Ser Val Val Asn Thr Leu Arg Gly Val Asp Phe 65 70 75 80 Ser Glu Asn Val Val Ser Phe Glu Glu Gln He Leu Asn Pro Val Wing 85 90 95 Pro Lys Lys Met Val Val Gly Wing Gly Wing He Gly Met Glu Phe 100 105 110 Wing Tyr Val Leu Gly Asn Tyr Gly Val Asp Val Thr Val He Glu Phe 115 120 125 25 Met Asp Arg Val Leu Pro Asn Glu Asp Ala Glu Val Ser Lys Val He ítJ? . 130 135 140 Wing Lys Wing Tyr Lys Lys Met Gly Val Lys Leu Leu Pro Gly His Wing 145 150 155 160 Thr Thr Wing Val Arg Asp Asn Gly Asp Phe Val Glu Val Asp Tyr Gln 165 170 175 Lys Lys Gly Ser Asp Lys Thr Glu Thr Leu Thr Val Asp Arg Val Met 180 185 190 Val Ser Val Gly Phe Arg Pro Arg Val Glu Gly Phe Gly Leu Glu Asn 195 200 205 Thr Gly Val Lys Leu Thr Glu Arg Gly Wing He Glu He Asp Asp Tyr 210 215 220 Met Arg Thr Asn Val Asp Gly He Tyr Wing He Gly Asp Val Thr Wing 225 230 235 240 Lys Leu Gln Leu Wing His Val Wing Ala Glu Wing Gln Gly He Val Wing Wing 245 250 255 Glu Thr He Wing Wing Gly Wing Glu Thr Gln Thr Leu Gly Asp Tyr Met Met 260 265 270 Met Pro Arg Ala Thr Phe Cys Asn Pro Gln Val Ser Ser Phe Gly Tyr 275 280 285 Thr Glu Glu Gln Ala Lys Glu Lys Trp Pro Asp Arg Glu He Lys Val 290 295 300 Wing Ser Phe Pro Phe Ser Wing Asn Gly Lys Wing Val Gly Leu Wing Glu 305 310 315 320 Thr Asp Gly Phe Wing Lys He Val Wing Asp Wing Glu Phe Gly Glu Leu 325 330 335 Leu Gly Wing His Leu Val Gly Wing Asn Wing Ser Glu Leu He Asn Glu 340 345 350 Leu Val Leu Wing Gln Asn Trp Asp Leu Thr Thr Glu Glu He Ser Arg 355 360 365 Ser Val His He His Pro Thr Leu Ser Glu Wing Val Lys Glu Wing Wing 370 375 380 His Gly He Ser Gly His Met He Asn Phe 385 390 <; 210 > 225 < 211 > 294 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (271) < 223 > RXA01261 < 400 > 225 gtgggtgttt ttcattttct tccactctaa aattaagtat ggaaaaccaa ccgcacccgg 60 atgcacgaca atgacccact aaacacgtat ccttgaatgc gtg act gaa cat tat 115 Val Thr Glu His Tyr 1 5 gac gta gta gta etc gga gcc ggc ccc ggt ggc tat gtc tcc gcc ate 163 Asp Val Val Val Leu Gly Ala Gly Pro Gly Gly Tyr Val Ser Wing He 10 15 20 cgt gca gcg cag ctt ggc aag aag gtt gct gta att gag aag cag tac 211 Arg Ala Ala Gln Leu Gly Lys Val Val Ala Val He Glu Lys Gln Tyr 25 30 35 tgg ggt ggt gtt tgc cta aac gtg ggc tgc att ect tcc aaa gtc tet 259 Trp Gly Gly Val Cys Leu Asn Val Gly Cys He Pro Ser Lys Val Ser _ * ^ Á. ^ IL ,. 40 45 50 gat caá aaa cgc tgaagttgcc cataccttta ccc 294 Asp Gln Lys Arg 55 < 210 > 226 < 211 > 57 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 226 Val Thr Glu His Tyr Asp Val Val Val Leu Gly Ala Gly Pro Gly Gly 1 5 10 15 Tyr Val Ser Ala He Arg Ala Ala Gln Leu Gly Lys Val Val Val 20 25 30 He Glu Lys Gln Tyr Trp Gly Val Val Cys Leu Asn Val Gly Cys He 35 40 45 Pro Ser Lys Val Ser Asp Gln Lys Arg 50 55 < 210 > 227 10 < 211 > 555 < 212 > DNA < 213 > Corynebacterium glutamicum • < 220 > < 221 > CDS < 222 > (101) .. (532) < 223 > RXA01136 < 400 > 227 ccctcgcaac acegaeggta gcctcttgga aatggcgcgc ategtgegtg agctttcccg 60 ctaggacctg tctactgcct tcactttgtg cgaacaccgc atg acc ttg gat tac 115 15 Met Thr Leu Asp Tyr 1 5 ttc aag gca tc ggc act gac tat gct ttg gga ttg gct gca gag tcg 163 Phe Lys Wing Ser Gly Thr Asp Tyr Wing Leu Gly Leu Wing Wing Glu Ser 10 15 20 gaa ggg gca cga cgc act ggt ate ggc atg gcg agg gt gt ttc aag 211 Glu Gly Wing Arg Arg Thr Gly He Thr Gly Met Wing Wing Wing Phe Lys 25 30 35 gag ttt ggt ggt tgt ggt gag ate gac ctt gaa gca acc agg gta gaa 259 Glu Phe Ala Gly Cys Gly Glu He Asp Leu Glu Wing Thr Arg Val Glu 40 45 50 ggt ggc etc aaa gtt agt gga aag ctt cgt tgg gct tcc aac ttg tgc 307 20 Gly Gly Leu Lys Val Ser Gly Lys Leu Arg Trp Wing Ser Asn Leu Cys 55 60 65 gaa gat cca gtg att gtg ect gct gca aag acc gca gag ggc tta caa 355 Glu Asp Pro Val He Val Pro Ala Wing Lys Thr Ala Glu Gly Leu Gln 70 75 80 85 cta ctg gtc gt gt gca gt gca gaa acc gaa ggt gtc acc gtt gtc tet 403 Leu Leu Phe Ala Leu Gly Glu Wing Thr Glu Glu Val Thr Leu Gly Ser 90 95 100 tea ctt gct cta etc ggt ttg aac gca act gct tgc gct tgg gtg age 451 Ser Leu Ala Leu Leu Gly Leu Asn Ala Thr Ala Cys Ala Trp Val Ser 105 110 115 ttt gag gat gtc ttc att ect ggg gct cag att cta age cae gat ttc 499 25 «^^ ¡Ü ^^ M ^ Phe Glu Asp Val Phe He Pro Gly Wing Gln He Leu Ser His Asp Phe 120 125 130 ctt acc ttg tgg cat cgg tgc gcc caá ect tcg tgatcctacg gatetcegaa 552 Leu Thr Leu Trp His Arg Cys Ala Gln Pro Ser 135 140 tac 555 < 210 > 228 < 211 > 144 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 228 Met Thr Leu Asp Tyr Phe Lys Wing Ser Gly Thr Asp Tyr Wing Leu Gly 1 5 10 15 Leu Wing Wing Glu Wing Glu Gly Wing Arg Arg Thr Gly He Thr Gly Met 20 25 30 Wing Wing Wing Phe Lys Glu Phe Wing Gly Cys Gly Glu He Asp Leu Glu 35 40 45 Wing Thr Arg Val Glu Gly Gly Leu Lys Val Ser Gly Lys Leu Arg Trp 50 55 60 Wing Being Asn Leu Cys Glu Asp Pro Val He Val Pro Wing Wing Lys Thr 65 70 75 80 Wing Glu Gly Leu Gln Leu Leu Leu Phe Wing Leu Gly Wing Glu Thr Glu Gly 85 90 95 Val Thr Leu Gly Ser Ser Leu Wing Leu Leu Gly Leu Asn Wing Thr Wing 100 105 110 Cys Wing Trp Val Ser Phe Glu Asp Val Phe He Pro Gly Wing Gln He 115 120 125 Leu Ser His Asp Phe Leu Thr Leu Trp His Arg Cys Wing Gln Pro Ser 130 135 140 < 210 > 229 < 211 > 1140 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1117) < 223 > RXN00559 < 400 > 229 cccttcaatc < : agtctttga cggcc; aatac ggcttgccgg gtttecageg gatcaatect 60 catgaagcat < cagectagta cgaaccgtta aagtgtccat atg tet gat aat ccg 115 Met Ser Asp Asn Pro 1 5 cat gag aat ccc cgt gag aat cca falls cgc tcc cca gaa gtc gtc ctt 163 His Glu Asn Pro Arg Glu Asn Pro His Arg Ser Pro Glu Val Val Leu 10 15 20 cgt ttc atg gct gcc ect act gac gtt ttg atg gct ggt age cat ggc 211 Arg Phe Met Ala Ala Pro Thr Asp Val Leu Met Ala Gly Ser His Gly 25 30 35 gtt ggc ggt ggc cga gtc ctg gaa tgg ate gat aag gct gct tat gct 259 Val Gly Gly Gly Arg Val Leu Glu Trp He Asp Lys Wing Wing Tyr Wing 40 45 50 tgt gct acc cag tgg tet gga acc tac tgt gtc Act gct tat gtt ggt 307 , rr * 4. l? l.rl Cys Wing Thr Gln Trp Ser Gly Thr Tyr Cys Val Thr Wing Tyr Val Gly 55 60 65 falls att falls ttc act cgc ect att ccc tet ggc falls atg gtc gag gtg 355 His He His Phe Thr Arg Pro He Pro Ser Gly His Met Val Glu Val 70 75 80 85 cgt tc cgc att gcg atg act ggc ct tcc tcc atg cae ate gtg aat 403 Arg Ser Arg He Wing Met Thr Gly Arg Ser Ser Met His He Val Asn 90 95 100 gag gtg ctt tet gcg gat ect cgc gat ggc aac tac acc cgt gcg tgt 451 • Glu Val Leu Ser Wing Asp Pro Arg Asp Gly Asn Tyr Thr Arg Wing Cys 105 110 115 gac tgc ttg gtt att ttc gtg gcg aag gac acc gcact act ggt cgc gct 499 Asp Cys Leu Val He Phe Val Wing Lys Asp Thr Wing Thr Gly Arg Ala 120 125 130 acc cca gtt ect tea ttt acc ect aag aat gaa gag gag cag cgc gtg 547 Thr Pro Val Pro Ser Phe Thr Pro Lys Asn Glu Glu Glu Gln Arg Val 135 140 145 ttg gaa gct gct aac tcc cgc ate ggg ctg cgc aag gct att gaa gcg 595 Leu Glu Ala Ala Asn Ser Arg He Gly Leu Arg Lys Ala He Glu Ala 150 155 160 165 gag 10 atg gaa aag cag acg tac aac gga ect tet gag gcc ect cgt ttg 643 Glu Met Glu Lys Gln Thr Tyr Asn Gly Pro Ser Glu Wing Pro Arg Leu 170 175 180 att acc cgc ttc ttg gct aag cca here gat aac tgg ggt ggc aag 691 • He Thr Arg Phe Leu Wing Lys Pro Thr Asp He Asn Trp Gly Gly Lys 185 190 195 gtc falls ggt ggc act gcc atg gaa tgg ate gat gag gcg ggt gct gcg 739 Val His Gly Gly Thr Wing Met Glu Trp He Asp Glu Wing Gly Wing Wing 200 205 210 tgc acc atg gag tgg tet ggt aac falls acc gtt gcg gtt tat gct ggt 787 Cys Thr Met Glu Trp Ser Gly Asn His Thr Val Wing Val Tyr Wing Gly 215 220 225 15 ggt ate cgc ttc tac cag ccc att cag ate ggt gac etc att gag gtg 835 Gly He Arg Phe Tyr Gln Pro He Gln He Gly Asp Leu He Glu Val 230 235 240 245 gac gcc cgc atg atg cgt acc gat aag cgt tcc atg cag atg tcc ate Asp Ala Arg Met Met Arg Thr Asp Lys Arg Ser Met Gln Met Ser He 250 255 260 falls gtc cgt gcc ggt gat gct falls cgt ggc cgt gct gag cta gaa acc 931 His Val Arg Ala Gly Asp Ala His Arg Gly Arg Ala Glu Leu Glu Thr 265 270 275 • gct att falls gca acg gtg acc tac tta gga att gat gtc gac gga gag 979 Ala He His Wing Thr Val Thr Tyr Leu Gly He Asp Val Asp Gly Glu 280 285 290 20 ect ttg ect gca cca cag ttt gtg ect cgt acc ect gag gat ate cag 1027 Pro Leu Pro Wing Pro Gln Phe Val Pro Arg Thr Pro Glu Asp He Gln 295 300 305 ttg gct gag cat gca aac ate ctg agg gat ctg cgt gct gat tac acc 1075 Leu Ala Glu His Wing Asn He Leu Arg Asp Leu Arg Wing Asp Tyr Thr 310 315 320 325 cca atg ccg ctg ttc cag cgc agg gtt cca ctg cag ate gac 1117 Pro Met Pro Leu Phe Gln Arg Arg Val Pro Leu Gln He Asp 330 335 tagttaga .ce c: gaaaaagcc ccc 1140 < 210 > 230 25 < 211 > 339 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 230 Met Ser Asp Asn Pro His Glu Asn Pro Arg Glu Asn Pro His Arg Ser 1 5 10 15 Pro Glu Val Val Leu Arg Phe Met Ala Wing Pro Thr Asp Val Leu Met 20 25 30 Wing Gly Ser His Gly Val Gly Gly Gly Arg Val Leu Glu Trp He Asp • 35 40 45 Lys Ala Ala Tyr Ala Cys Ala Thr Gln Trp Ser Gly Thr Tyr Cys Val 50 55 60 Thr Ala Tyr Val Gly His He His Phe Thr Arg Pro He Pro Ser Gly 65 70 75 80 His Met Val Glu Val Arg Ser Arg He Wing Met Thr Gly Arg Ser Ser 85 90 95 Met His He Val Val Valu Glu Val Leu Ser Wing Asp Pro Arg Asp Gly Asn 100 105 110 Tyr Thr Arg Wing Cys Asp Cys Leu Val He Phe Val Wing Lys Asp Thr 115 120 125 Wing Thr Gly Arg Wing Thr Pro Val Pro 10 Ser Phe Thr Pro Lys Asn Glu 130 135 140 Glu Glu Gln Arg Val Leu Glu Wing Wing Asn Ser Arg He Gly Leu Arg 145 150 155 160 • Lys Wing He Glu Wing Glu Met Glu Lys Gln Thr Tyr Asn Gly Pro Ser 165 170 175 Glu Wing Pro Arg Leu He Thr Arg Phe Leu Wing Lys Pro Thr Asp He 180 185 190 Asn Trp Gly Gly Lys Val His Gly Gly Thr Wing Met Glu Trp He Asp 195 200 205 Glu Wing Gly Wing Wing Cys Thr Met Glu Trp Ser Gly Asn His Thr Val 210 215 220 15 Wing Val Tyr Wing Gly Gly He Arg Phe Tyr Gln Pro He Gln He Gly 225 230 235 240 Asp Leu He Glu Val Asp Ala Arg Met Met Arg Thr Asp Lys Arg Ser 245 250 255 Met Gln Met Ser He His Val Arg Ala Gly Asp Ala His Arg Gly Arg 260 265 270 Ala Glu Leu Glu Thr Ala He His Ala Thr Val Thr Tyr Leu Gly He 275 280 285 Asp Val Asp Gly Glu Pro Leu Pro Pro Wing Gln Phe Val Pro Arg Thr • 290 295 300 Pro Glu Asp He Gln Leu Wing Glu His Wing Asn He Leu Arg Asp Leu 305 310 315 320 20 Arg Ala Asp Tyr Thr Pro Met Pro Leu Phe Gln Arg Arg Val Pro Leu 325 330 335 Gln He Asp < 210 > 231 < 211 > 313 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (313) 25 < 223 > FRXA00559 t A. ».,. < 400 > 231 cccttcaatc cagtetttga cggccaatac ggcttgccgg gtttecageg gatcaatect 60 catgaagcat cagectagta cgaaccgtta aagtgtccat atg tet gat aat ccg 115 Met Ser Asp Asn Pro 1 5 cat gag aat ccc cgt gag aat cca cc ccc cc gaa gtc gtc ctt 163 His Glu Asn Pro Arg Glu Asn Pro His Arg Ser Pro Glu Val Val Leu 10 15 20 cgt ttc atg gct gcc ect act gac gtt ttg atg gct ggt age cat ggc 211 Arg Phe Met Ala Ala Pro Thr Asp Val Leu Met Wing Gly Ser His Gly 25 30 35 gtt ggc ggt ggc cga gtc ctg gaa tgg ggg ggc gct tat gct tat gct 259 Val Gly Gly Gly Arg Val Leu Glu Trp He Asp Lys Wing Wing Tyr Wing 40 45 50 tgt gct ggg tet ggg tet gga acc gtc gtc act gtc tat gtt ttat ggt 307 Cys Ala Thr His Gly Ser Gly Thr Tyr Cys Val Thr Ala Tyr Val Gly 55 60 65 falls att 313 His He 70 10 < 210 > 232 < 211 > 71 • < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 232 Met Ser Asp Asn Pro His Glu Asn Pro Arg Glu Asn Pro His Arg Ser 1 5 10 15 Pro Glu Val Val Leu Arg Phe Met Ala Wing Pro Thr Asp Val Leu Met 20 25 30 15 Wing Gly Ser His Gly Val Gly Gly Gly Arg Val Leu Glu Trp He Asp 35 40 45 Lys Ala Ala Tyr Ala Cys Ala Thr His Gly Ser Gly Thr Tyr Cys Val 50 55 60 Thr Ala Tyr Val Gly His He 65 70 < 210 > 233 < 211 > 802 • < 212 > DNA < 213 > Corynebacterium glutamicum 20 < 220 > < 221 > CDS < 222 > (101) .. (802) < 223 > RXA01580 < 400 > 233 cggtaaacgc ctcattaaag tccaatgcca tgetcataac actaacagtt aaccgtgcgg 60 tcaactttgc tccctatcct taaaaagccc acagaaaagg atg tat aag aat atg 115 Met Tyr Lys Asn Met 1 5 fall att gtt gcc cat cgc ggt gcg gaa gat ctg falls etc gaa aac acc 163 His He Val Ala His Arg Gly Ala Glu Asp Leu His Leu Glu Asn Thr 10 15 20 25 _ij ._? i.i, i..J¿t..l. atg acc gct ttc cag gct gcc gcg ccc gct gac gct ttt gag ctg gat 211 Met Thr Wing Phe Gln Wing Wing Wing Pro Wing Asp Wing Phe Glu Leu Asp 25 30 35 tet falls gcc acc gct gac aat cag gtc gtc gtt ate fall gac cgc acc 259 He His Wing Thr Wing Asp Asn Gln Val Val Val He He Asp Arg Thr 40 45 50 gca gcg cgt gtt gcc gcg cca gat tcc ctg falls cgc gac acc ccg gtt 307 Ala Ala Arg Ala Ala Ala Pro Asp Ser Leu His Arg Asp Thr Pro Val 55 60 65 gcg cgc tta age gcc gcg caa ate aag gag ata acg ctt ate gac gga 355 Wing Arg Leu Wing Wing Gln He Lys Glu He Thr Leu He Asp Gly 70 75 80 85 tcc ccc gta cca acc ctg gag gaa gtt cta etc cag acg age ctg ccg 403 Be Pro Val Pro Thr Leu Glu Glu Val Leu Leu Gln Thr Be Leu Pro 90 95 100 ate ca gtg gaa ate aaa tet gcc ggt gca gtt cca gca gcc gca gca 451 He Gln Val Glu He Lys Ser Ala Gly Ala Val Pro Ala Ala Ala Ala 105 110 115 tta ttg cag aaa tac cca gag cae ctg gag cgc ctg ctg ttc ate agt 499 Leu Leu Gln Lys Tyr Pro Glu His Leu Glu Arg Leu Leu Phe He Ser 120 125 130 ttc ate gat gca gtc gtg gtg gaa ate gtg gat cga ctg cca gaa gct 547 Phe He Asp Ala Wing Leu Val Glu He Val Asp Arg Leu Pro Glu Ala 135 140 145 cgc gtg gga ate ttg cgc gat gcg tcc atg gat gat ctg cgc att ctt 595 Arg Val Gly He Leu Arg Asp Ala Ser Met Asp Asp Leu Arg He Leu 150 155 160 165 gat tac ate ccg cta aaa aat gtg ggc gcg ate ttg ccc tcg tgg aaa 643 Asp Tyr He Pro Leu Lys Asn Val Gly Wing He Leu Pro Ser Trp Lys 170 175 180 gca cta aac gtg gcg tea att gct gat cta cat acc aag gga ate aag 691 Wing Leu Asn Val Wing Being Wing Asp Leu His Thr Lys Gly He Lys 185 190 195 gtt ggc tgc tgg here att cgg gat gaa aat gcg ttt ggg ate gca ca 739 Val Gly Cys Trp Thr He Arg Asp Glu Asn Wing Phe Gly He Wing Gln 200 205 210 cacta gct ggc gtt gat tac ccc act gtt age gat ccc tet cgt ttc tcg 787 Gln Ala Gly Val Asp Tyr Pro Thr Val Ser Asp Pro Ser Arg Phe Ser 215 220 225 cgc ect ccc ctg ctg 802 Arg Pro Pro Leu Leu 230 < 210 > 234 < 211 > 234 < 212 > PRT < 213 > Corynebact: erium gl .utamicum < 400 > 234 Met Tyr Lys Asn Met His He Val Wing His Arg Gly Wing Glu Asp Leu 1 5 10 15 His Leu Glu Asn Thr Met Thr Wing Phe Gln Wing Wing Wing Pro Wing Asp 20 25 30 Wing Phe Glu Leu Asp He His Wing Thr Wing Asp Asn Gln Val Val Val 35 40 45 He His Asp Arg Thr Wing Wing Arg Val Ala Ala Pro Asp Ser Leu His 50 55 60 Arg Asp Thr Pro Val Wing Arg Leu Wing Wing Gln He Lys Glu He 65 70 75 80 Thr Leu He Asp Gly Ser Pro Val Pro Thr Leu Glu Val Val Leu Leu 85 90 95 Gln Thr Ser Leu Pro He Gln Val Glu He Lys Ser Wing Gly Ala Val 100 105 110 Pro Wing Wing Wing Wing Leu Leu Gln Lys Tyr Pro Glu His Leu Glu Arg 115 120 125 Leu Leu Phe He Ser Phe He Asp Ala Wing Leu Val Glu He Val Asp • 130 135 140 Arg Leu Pro Glu Wing Arg Val Gly He Leu Arg Asp Wing Ser Met Asp 145 150 155 160 Asp Leu Arg He Leu Asp Tyr He Pro Leu Lys Asn Val Gly Wing He 165 170 175 Leu Pro Ser Trp Lys Ala Leu Asn Val Ala Ser He Wing Asp Leu His 180 185 190 Thr Lys Gly He Lys Val Gly Cys Trp Thr He Arg Asp Glu Asn Wing 195 200 205 Phe Gly He Wing Gln Gln Wing Gly Val Asp Tyr Pro Thr Val Ser Asp 210 215 220 10 Pro Ser Arg Phe Ser Arg Pro Pro Leu Leu 225 230 < 210 > 235 • < 211 > 882 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (859) < 223 > RXA02677 15 < 400 > 235 ttaigtgcagt < gtatttattt ccgttt :: acg < 2 tqt = ggggctg gtggttttgga < gggatactag 60 agticgat; age; aggt; atataa a < ggccaggatg agatgggttc atg aaa gtc ate gcg 115 Met Lys Val He Wing 1 5 falls cg ggt tta tcg tet cgc ttt ccc gaa tta here gag tet gcg ttt 163 His Arg Gly Leu Ser Ser Arg Phe Pro Glu Leu Thr Glu Be Wing Phe 10 15 20 • cgg gcg gct cta gag cta ccg att cat gga att gaa act gat gtc cgg 211 Arg Ala Ala Leu Glu Leu Pro He His Gly He Glu Thr Asp Val Arg 25 30 35 20 ctg act aaa tgt ggc gaa gtg gtt aac gtc cat gac ccc att gtg gat 259 Leu Thr Lys Cys Gly Glu Val Val Asn Val His Asp Pro He Val Asp 40 45 50 cgc gtg tcg aat ggt cgc ggt cgg gtg tcg cgt ttg gac ttg gaa tcc 307 Arg Val Ser Asn Gly Arg Gly Arg Val Ser Arg Leu Asp Leu Glu Ser 55 60 65 ttg ctg age ttg aac ttt gga acc aaa gaa acc cca gaa aaa gtg ctt 355 Leu Leu Ser Leu Asn Phe Gly Thr Lys Glu Thr Pro Glu Lys Val Leu 70 75 80 85 act tta aac aat cta tta gat att ttt gag gat tat cca gat aag cae 403 Thr Leu Asn Asn Leu Leu Asp He Phe Glu Asp Tyr Pro Asp Lys His 90 95 100 25 ctt tat ata gaa acc aag falls cca atg cgc tac gcg gtc atg ctg gaa 451 Leu Tyr He Glu Thr Lys His Pro Met Arg Tyr Ala Val Met Leu Glu 105 110 115 gaa gaa ate aaa a tta aaa tat cgt ggg ctg acg gaa gac cca 499 Glu Glu He Thr Lys He Leu Lys Tyr Arg Gly Leu Thr Glu Asp Pro 120 125 130 cgc ate fits att tet ttt gca ctt ccc gcg atg tat cgc atg gct 547 Arg He His He He Be Phe Wing Leu Pro Wing Met Tyr Arg Met Wing 135 140 145 cgc ctt gct cca cag ctt gat cgc att cat ctg cgc agg tcg tgg gag 595 Arg Leu Ala Pro Gln Leu Asp Arg He His Leu Arg Arg Ser Trp Glu 150 155 160 165 cgt tgg ggt aat ccg cgc gat gtg cgc tgc ggt gta ccc acc ggt ttg 643 Arg Trp Gly Asn Pro Arg Asp Val Arg Cys Gly Val Pro Thr Gly Leu 170 175 180 ggg ttg tcg ctg gag cgg gcg aag atg gat cca agg atg att ggg gcg 691 Gly Leu Ser Leu Glu Arg Wing Lys Met Asp Pro Arg Met He Gly Wing 185 190 195 aaa ggg tta ccc acc tat ctt ttc acc gtc gat aag caa aaa gac atg 739 Lys Gly Leu Pro Thr Tyr Leu Phe Thr Val Asp Lys Gln Lys Asp Met 200 205 210 ctg tgg gcg cgc gaa cag ggc gtc gac atg etc gcc acc aat tat ccg 787 Leu Trp Wing Arg Glu Gln Gly Val Asp Met Leu Wing Thr Asn Tyr Pro 215 220 225 gac cgt gcg gcg gag ctt ttg aac gca cat ccc aag ccc gcc atg tac 835 Asp Arg Wing Wing Glu Leu Leu Asn Wing His Pro Lys Pro Wing Met Tyr 230 235 240 245 gct aat gcg cat ggc aaa gaa gac taagaagaat gaacagctgc cgg 882 Ala Asn Ala His Gly Lys Glu Asp 250 < 210 > 236 < 211 > 253 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 236 Met Lys Val He Wing His Arg Gly Leu Ser Ser Arg Phe Pro Glu Leu 1 5 10 15 Thr Glu Be Wing Phe Arg Wing Wing Leu Glu Leu Pro He His Gly He 20 25 30 Glu Thr Asp Val Arg Leu Thr Lys Cys Gly Glu Val Val Asn Val His 35 40 45 Asp Pro He Val Asp Arg Val Ser Asn Gly Arg Gly Arg Val Ser Arg 50 55 60 Leu Asp Leu Glu Ser Leu Leu Ser Leu Asn Phe Gly Thr Lys Glu Thr 65 70 75 80 Pro Glu Lys Val Leu Thr Leu Asn Asn Leu Leu Asp He Phe Glu Asp 85 90 95 Tyr Pro Asp Lys His Leu Tyr He Glu Thr Lys His Pro Met Arg Tyr 100 105 110 Wing Val Met Leu Glu Glu Glu He Thr Lys He Leu Lys Tyr Arg Gly 115 120 125 Leu Thr Glu Asp Pro Arg He His He He Ser Phe Ala Leu Pro Wing 130 135 140 Met Tyr Arg Met Wing Arg Leu Wing Pro Gln Leu Asp Arg He His Leu 145 150 155 160 Arg Arg Ser Trp Glu Arg Trp Gly Asn Pro Arg Asp Val Arg Cys Gly . fc .. r »... t, .á 165 170 175 Val Pro Thr Gly Leu Gly Leu Ser Leu Glu Arg Wing Lys Met Asp Pro 180 185 190 Arg Met He Gly Wing Lys Gly Leu Pro Thr Tyr Leu Phe Thr Val Asp 195 200 205 Lys Gln Lys Asp Met Leu Trp Wing Arg Glu Gln Gly Val Asp Met Leu 210 215 220 Wing Thr Asn Tyr Pro Asp Arg Wing Wing Glu Leu Leu Asn Wing His Pro 225 230 235 240 • Lys Pro Ala Met Tyr Ala Asn Ala His Gly Lys Glu Asp 245 250 < 210 > 237 < 211 > 1428 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1405) < 223 > RXS01166 10 < 400 > 237 acctgtaecca a < gaattaaca gaaacagact gaaaaacaac atcgctcgac 60 • atgt Dgcgtaa cgcacactaa tgtggccgat atg ggc tac ac aac 115 Met Gly Tyr Thr Asn 1 5 etc aac gac here cgg gtc ttg cgc gcc ggg tea tgt gat gcc tgg tgg 163 Leu Asn Asp Thr Arg Val Leu Arg Wing Gly Ser Cys Asp Wing Trp Trp 10 15 20 cgc acg atg tet ccg cta gtg cag cag gga agt gag gca gtc ttt cgg 211 Arg Thr Met Ser Pro Leu Val Gln Gln Gly Ser Glu Wing Val Phe Arg 25 30 35 15 cgc ate atg ggt etc tcg cgg cgt ect gat cgg aaa ect ggc ttt gac 259 Arg He Met Gly Leu Ser Arg Arg Pro Asp Arg Lys Pro Gly Phe Asp 40 45 50 gat gtc cca cat ttc ggc gca gct gtt cga gtt ccc ggt cta aaa falls 307 Asp Val Pro His Phe Gly Wing Wing Val Arg Val Pro Gly Leu Lys His 55 60 65 ggc acg ttg gtc aat gct gca ccc ttg aaa gtt ttg ggc gca cgg ggc 355 Gly Thr Leu Val Asn Ala Wing Pro Leu Lys Val Leu Gly Wing Arg Gly • 70 75 80 85 gag ccc aac ccc gcg agt tcg tac ct ttt gaa tac ate acc ggt gat 403 Glu Pro Asn Pro Wing Being Ser Tyr Arg Phe Glu Tyr He Thr Gly Asp 90 95 100 20 tcc gca ggt cga gcc ate act gcg gcg gcc gctc etc ttt tcc here 451 Be Wing Gly Arg Wing He Thr Wing Thr Gly Wing Val Leu Phe Ser Thr 105 110 115 cgc ccc tgg here ac gcc ccg cgt ccc gcg ate gcc atg gct cca tcc 499 Arg Pro Trp Thr Thr Gly Pro Arg Pro Wing He Wing Met Wing Pro Pro 120 125 130 acc g gc gca gca gca cag falls tgc gat ccc tcc falls acc tgc gcc ate 547 Thr Gln Gly Val Wing Gln His Cys Asp Pro Ser His Thr Cys Ala He 135 140 145 gga etc aac gca ttc tat gac aaa ccc ttc gac gca ate att gct tac 595 Gly Leu Asn Wing Phe Tyr Asp Lys Pro Phe Asp Wing He He Wing Tyr 165 25 150 155 160 ^ l ié * A *. "_u __- rit, _ 4.? gaa etc ccc gtc ate etc tgg ttt cta gct falls gga ctt gac gtt gtg 643 Glu Leu Pro Val Le Leu Trp Phe Leu Ala His Gly Leu Asp Val Val 170 175 180 ttc ate gat tac ccc cgc gac ccc gca acc ggc gtc ca ta tac tat tgc 691 Phe He Asp Tyr Pro Arg Asp Pro Wing Thr Gly Val Gln Tyr Tyr Cys 185 190 195 gat tcc ate gct gca gct aaa tcg ctt etc gac gcc gtc etc gcc tcc 739 Asp Ser He Ala Ala Ala Lys Ser Leu Leu Asp Wing Val Leu Ala Ser 200 205 210 • aga caa etc ggc ctt tea ccg gaa gca ccg ctt ggc ctg tgg gga ttc 787 Arg Gln Leu Gly Leu Ser Pro Glu Pro Wing Pro Leu Gly Leu Trp Gly Phe 215 220 225 tcc ca g ggc ggc ggc gcc act ggc tgg gct gca caca ttg cag gat tac 835 Ser Gln Gly Gly Gly Wing Thr Gly Trp Wing Wing Gln Leu Gln Asp Tyr 230 235 240 245 gca ect gat gtc cgc cca aag gca gcg gtc gtg ggc gct cca cca gtg 883 Wing Pro Asp Val Arg Pro Lys Wing Wing Val Val Gly Wing Pro Pro Val 250 255 260 gat etc ttc cgc gtc ttg gac act gtc gac ggc gga ttg etc acc gga 931 Asp Leu Phe Arg Val Leu Asp Thr Val Asp Gly Gly Leu Leu Thr Gly 10 265 270 275 gtg att gcc tac gcc ate gcg gga ctt gca gtg aac tet tea gag atg 979 Val He Ala Tyr Ala He Ala Gly Leu Ala Val Asn Ser Ser Glu Met 280 285 290 • ttt gag gaa ate atg tcg gtg tta aat gaa cgc gga gtc agt gat gtg 1027 Phe Glu Glu He Met Ser Val Leu Asn Glu Arg Gly Val Ser Asp Val 295 300 305 ctg aaa aat ate age gcg gga ggt tcc ttg tcg gcc agt ggc 1075 leu lys Asn He Thr Ser Cys Wing Gly Gly Ser Leu Leu Wing Ser Gly 310 315 320 325 tac tcg tet tcc cgc ggg tgg here cat cag ggc acg ccg ctg gca gac 1123 Tyr Ser Ser Be Arg Gly Trp Thr His Gln Gly Thr Pro Leu Ala Asp 15 330 335 340 att ctg gac gat ctg cca ctt gtt gtc gct gag ttt ggg aag caa aag 1171 He Leu Asp Asp Leu Pro Leu Val Val Ala Glu Phe Gly Lys Gln Lys 345 350 355 ctg ggt cgt gtg gcg cca gaa ate cca gtg ctg ttg tgg ggc tet aaa 1219 Leu Gly Arg Val Wing Pro Glu He Pro Val Leu Leu Trp Gly Ser Lys 360 365 370 aat gat gat gtc att ccc att gat ccc att agg gaa ttg cgt gat age 1267 Asn Asp Asp Val He Pro He Asp Pro He Arg Glu Leu Arg Asp Ser 375 380 385 tgg gcg gac aag ggt acg cca ttg acc tgg cat gaa tcc cac gcg ccg 1315 Trp Wing Asp Lys Gly Thr Pro Leu Thr Trp His Glu Ser Gln Wing Pro 20 390 395 400 405 cgt gtg cca gga cgc here ggt etc aac cat ttc ggg ccc tat ttt aga 1363 Arg Val Pro Gly Arg Thr Gly Leu Asn His Phe Gly Pro Tyr Phe Arg 410 415 420 aac ctg gaa aag tac tg gga tgg etc ata gat cat ctt gtc 1405 Asn Leu Glu Lys Tyr Ser Gly Trp Leu He Asp His Leu Val 425 430 435 tgagtgccgt tttaaaggct cgg 1428 < 210 > 238 < 211 > 435 < 212 > PRT 25 < 213 > Corynebacterium glutamicum Ü¡g¡g¡ ^ < 400 > 238 Met Gly Tyr Thr Asn Leu Asn Asp Thr Arg Val Leu Arg Wing Gly Ser 1 5 10 15 Cys Asp Wing Trp Trp Arg Thr Met Ser Pro Leu Val Gln Gln Gly Ser 20 25 30 Glu Wing Val Phe Arg Arg He Met Gly Leu Ser Arg Arg Pro Asp Arg 35 40 45 Lys Pro Gly Phe Asp Asp Val Pro His Phe Gly Wing Wing Val Arg Val • 50 55 60 Pro Gly Leu Lys His Gly Thr Leu Val Asn Ala Wing Pro Leu Lys Val 65 70 75 80 Leu Gly Wing Arg Gly Glu Pro Asn Pro Wing Being Ser Tyr Arg Phe Glu 85 90 95 Tyr He Thr Gly Asp Being Wing Gly Arg Wing He Thr Wing Thr Gly Wing 100 105 110 Val Leu Phe Ser Thr Arg Pro Trp Thr Thr Gly Pro Arg Pro Ala He 115 120 125 Wing Met Wing Pro Ser Thr Gln Gly Val Wing Gln His Cys Asp Pro Ser 130 135 140 His Thr Cys Wing He Gly Leu Asn Wing Phe Tyr Asp Lys Pro Phe Asp 10 145 150 155 160 Wing He He Wing Tyr Glu Leu Pro Val He Leu Trp Phe Leu Wing His 165 170 175 • Gly Leu Asp Val Val Phe He Asp Tyr Pro Arg Asp Pro Wing Thr Gly 180 185 190 Val Gln Tyr Tyr Cys Asp Ser Wing Wing Wing Wing Lys Ser Leu Leu Asp 19 5 200 205 Wing Val Leu Wing Ser Arg Gln Leu Gly Leu Pro Pro Glu Wing Pro Leu 210 215 220 Gly Leu Trp Gly Phe Ser Gln Gly Gly Gly Wing Thr Gly Trp Wing Wing 225 230 235 240 Gln Leu Gln Asp Tyr Wing Pro Asp Val Arg Pro 15 Lys Wing Wing Val Val 245 250 255 Gly Wing Pro Pro Val Asp Leu Phe Arg Val Leu Asp Thr Val Asp Gly 260 265 270 Gly Leu Leu Thr Gly Val He Wing Tyr Wing He Wing Gly Leu Wing Val 275 280 285 Asn Be Ser Glu Met Phe Glu Glu He Met Ser Val Leu Asn Glu Arg 290 295 300 Gly Val Ser Asp Val Leu Lys Asn He Thr Ser Cys Wing Gly Gly Ser 305 310 315 320 Leu Leu Wing Ser Gly Tyr Ser Ser Ser Arg Gly Trp Thr His Gln Gly 325 330 335 Thr Pro Leu Wing Asp He Leu Asp Asp Leu Pro Leu Val Val Wing Glu 20 340 345 350 Phe Gly Lys Gln Lys Leu Gly Arg Val Wing Pro Glu He Pro Val Leu 355 360 365 Leu Trp Gly Ser Lys As Asp Asp Asp Asp Pro He Asp Pro He Arg 370 375 380 Glu Leu Arg Asp Ser Trp Wing Asp Lys Gly Thr Pro Leu Thr Trp His 385 390 395 400 Glu Ser Gln Ala Pro Arg Val Pro Gly Arg Th r Gly Leu Asn His Phe 405 410 415 Gly Pro Tyr Phe Arg Asn Leu Glu Lys Tyr Ser Gly Trp Leu He Asp 420 425 430 25 His Leu Val .. S ***** »** 435 < 210 > 239 < 211 > 690 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (667) < 223 > RXA00875 < 400 > 239 caatttggcg gcgctgctgg gtgatcgggg gccggttgtt ccgggtgtga ttggtgactg 60 ggtgaggggc taacgcaaca atgtgtctaa gcttaggggc atg act act gag gtt 115 Met Thr Thr Glu Val 1 5 gaa ctg gtt gtt tta gct gat tcc gag ggc aat ect att ggt act gcg 163 Glu Leu Val Val Leu Wing Asp Ser Glu Gly Asn Pro He Gly Thr Wing 10 15 20 ccg aaa gct acg gtg falls act aag gac acct ect ctg cat ttc gcg ttt 211 Pro Lys Wing Thr Val His Thr Lys Asp Thr Pro Leu His Phe Wing Phe 25 30 35 tcc acc tat att ttg aac ccg cgt ggg gag ctg ttg gtg acg cgt cgt 259 Be Thr Tyr He Leu Asn Pro Arg Gly Glu Leu Leu Val Thr Arg Arg 40 45 50 gca ttg tcg aag aag a tgg ect ggt gtg tgg acg aac tet atg tgt 307 Ala Leu Ser Lys Lys Thr Trp Pro Gly Val Trp Thr Asn Ser Met Cys 55 60 65 ggg falls ect ggt ccg gat gag here aac gcg gat gcg att cgt cgc agg 355 Gly His Pro Gly Pro Asp Glu Thr Asn Wing Asp Wing He Arg Arg Arg 70 75 80 85 ggt gtc gat gag ttg ggg ctg gag gta gat tet ttc ttg gat att caa 403 Gly Val Asp Glu Leu Gly Leu Glu Val Asp Ser Phe Leu Asp He Gln 90 95 100 gag att ctg ect gat tac cag tac cgt gct gtc gac gcg tcc ggc att 451 Glu He Leu Pro Asp Tyr Gln Tyr Arg Wing Val Asp Wing Ser Gly He 105 110 115 gtg gag tgg gag ttg tgc ccg gtc drops etc gtg cgt tta gcg gtg ggg 499 Val Glu Trp Glu Leu Cys Pro Val His Leu Val Arg Leu Wing Val Gly 120 125 130 gaa ttt gtg gag cca ctg gat gat gag gtg gag gag ttc gag tgg gcg 547 Glu Phe Val Glu Pro Leu Asp Asp Glu Val Glu Glu Phe Glu Trp Wing 135 140 145 gaa ccg cag aag ctt ttc gac gct gtt gat gcc here cca ttt gtg ttt 595 Glu Pro Gln Lys Leu Phe Asp Ala Val Asp Ala Thr Pro Phe Val Phe 150 155 160 165 tet cca tgg cta gtg gat cag ctt age gcc ect gag ctg cgc ca gcc 643 Ser Pro Trp Leu Val Asp Gln Leu Ser Wing Pro Glu Leu Arg Gln Wing 170 175 180 ate ctg gaa gcg ttt gac gca gag taactaacta gtetagaage ctt 690 He Leu Glu Ala Phe Asp Ala Glu 185 < 210 > 240 < 211 > 189 < 212 > PRT ..1 .... »., Fc.t i < 213 > Corynebacterium glutamicum < 400 > 240 Met Thr Thr Glu Val Glu Leu Val Val Leu Wing Asp Ser Glu Gly Asn 1 5 10 15 Pro He Gly Thr Wing Pro Lys Wing Thr Val His Thr Lys Asp Thr Pro 20 25 30 Leu His Phe Wing Phe Ser Thr Tyr He Leu Asn Pro Arg Gly Glu Leu 35 40 45 • Leu Val Thr Arg Arg Ala Leu Ser Lys Lys Thr Trp Pro Gly Val Trp 50 55 60 Thr Asn Ser Met Cys Gly His Pro Gly Pro Asp Glu Thr Asn Wing Asp 65 70 75 80 Wing He Arg Arg Arg Gly Val Asp Glu Leu Gly Leu Glu Val Asp Ser 85 90 95 Phe Leu Asp He Gln Glu He Leu Pro Asp Tyr Gln Tyr Arg Ala Val 100 105 110 Asp Wing Ser Gly He Vallu Glu Trlu Glu Leu Cys Pro Val His Leu Val 115 120 125 Arg Leu Wing Val Gly Glu Phe Val Glu Pro Leu Asp Asp Glu Val Glu 10 130 135 140 Glu Phe Glu Trp Wing Glu Pro Gln Lys Leu Phe Asp Wing Val Asp Wing 145 150 155 160 Thr Pro Phe Val Phe Ser Pro Trp Leu Val Asp Gln Leu Ser Pro Wing • 165 170 175 Glu Leu Arg Gln Wing He Leu Glu Wing Phe Asp Wing Glu 180 185 < 210 > 241 < 211 > 1308 < 212 > DNA < 213 > Corynebacterium glutamicum 15 < 220 > < 221 > CDS < 222 > (101) .. (1285) < 223 > RXA01292 < 400 > 241 tccgcgtt: cc 1tegaagaett aaaaaacggg cgggattttg tgccgtcttt aaaaaagcca 60 gcctggcaac < : aaa (gcaatg tggaaagaag tgtttcaaaa atg here aaa gca gtg 115 • Met Thr Lys Ala Val 1 5 gtc ate ggc ggg gga cta gca gga cta gcc acc acc gca ctg etc tta 163 20 Val He Gly Gly Gly Leu Wing Gly Leu Wing Thr Thr Ala Leu Leu Leu 10 15 20 cgc gaa gga tat gaa gtc falls etc gtc gaa caac aac gag drops etc ggc 211 Arg Glu Gly Tyr Glu Val His Leu Val Glu Gln Asn Glu His Leu Gly 25 30 35 ggc cgc gcc ggg acc ttc gaa etc gac ggc tcc cgc tgg gac acc ggc 259 Gly Arg Wing Gly Thr Phe Glu Leu Asp Gly Phe Arg Trp Asp Thr Gly 40 45 50cc age tgg tac etc atg ccc gac gcc atg tcc falls ttc ttt aag etc. 307 Pro Ser Trp Tyr Leu Met Pro Asp Wing Met Ser His Phe Phe Lys Leu 55 60 65 tgc ggc acc tcc ate gac gac drops etc. gac etc gtg cca ctt gaa ccc 355 25 Cys Gly Thr Ser He Asp Asp His Leu Asp Leu Val Pro Leu Glu Pro 70 75 80 85 gcc tac cgc gtc ate gac gac cae ggc gaa ttc ate gac gtc acc tcc 403 Wing Tyr Arg Val He Asp Asp His Gly Glu Phe He Asp Val Thr Ser 90 95 100 gac ate gat gcg atg gcc gag ctt ttc gaa tcc cgc gaa ccc ggc gcc 451 Asp He Asp Wing Met Wing Glu Leu Phe Glu Ser Arg Glu Pro Gly Wing 105 110 115 ggc gcc aaa ctg cgc acc tat ate gac tcc gcc here cag gtc tac aac 499 • Wing Lys Leu Arg Thr Tyr He Asp Ser Wing Thr Gln Val Tyr Asn 5 Gly 120 125 130 ctg gcc ate gac ggc ttc etc tac acc aac ttc acc aac ttc ate cca 547 Leu Ala He Asp Gly Phe Leu Tyr Thr Asn Phe Thr Asn Phe He Pro 135 140 145 tac tta age ccc ggc atg ctc ctt cta cct tc cc aaa ctt cta gca age 595 Tyr Leu Ser Pro Gly Met Leu Arg Leu Leu Pro Lys Leu Leu Wing Ser 150 155 160 165 ctg tcg acc tcg cta aaa gtc aag gtc aac ac ct tcc cgc gat 643 Leu Ser Thr Ser Leu Lys Val Lys Val Asn Thr Gln Phe Arg Asp Thr 170 175 180 aaa ctc cgc ca ate ate tac ccc gca gtt ttc etc tcc tea gac 691 Leu Arg Gln He Leu Ser Tyr Pro Wing Val Phe Leu Ser Ser Asp 0 Lys 185 190 195 ect tcg falls acc ccg gcg etc tat falls etc atg age falls acc gac etc 739 Pro Ser His Thr Pro Ala Leu Tyr His Leu Met Ser His Thr Asp Leu • 200 205 210 gtc ca ggc gtc tcc tat ccc cg ggc ggc ttc acc gcc ttc ate aag 787 Val Gln Gly Val Ser Tyr Pro Arg Gly Gly Phe Thr Wing Phe He Lys 215 220 225 gca cta att tcg ctt at e gac gac gcc gtc etc drops etc ggc acc ccc 835 Wing Leu He Ser Leu He Asp Asp Wing Val Leu His Leu Gly Thr Pro 230 235 240 245 gtc age gca gcc ac acc gca gc gcc gc aac gcc gc gcc ca gcc 883 J _- Val Ser Wing He Thr Thr Gln Gly Arg Asn Wing Thr Gly Val Gln Val 250 255 260 ggc tea gag ttc ate gaa gcc gat ate gtg ate age tgc gct gat cag 931 Gly Ser Glu Phe He Glu Wing Asp He Val He Ser Cys Wing Asp Gln 265 270 275 falls falls acc gaa acc cata etc cta ect gct tcg tgc gcg aag ccg 979 His His Thr Glu Thr Gln Leu Leu Pro Wing Ser Leu Cys Wing Lys Pro 280 285 290 • gag acg age tgg aag aac aaa caac ccc ggc etc agt act gtg ctg gtt 1027 Glu Thr Ser Trp Lys Asn Lys Gln Pro Gly Leu Ser Thr Val Leu Val 295 300 305 ttg gca ggc gtg aag ggg gag drops acc ctg ctt ttt ect ccg act ggg 1075 Q Leu Wing Gly Val Lys Gly Glu His Thr Leu Leu Phe Pro Pro Thr Gly 310 315 320 325 acg aag att tcc gca aag ttt tcg acg gct cca ccc cag aat tc cgg 1123 Thr Lys He Ser Wing Lys Phe Ser Thr Wing Pro Pro Gln Asn Ser Arg 330 335 340 ctt cag aat cca tet aga tet cca aga ect ccg caa cag att ccg atg 1171 Leu Gln Asn Pro Ser Arg Pro Pro Arg Pro Pro Gln Gln Pro Pro Met 345 350 355 ccg falls ccg aag gcc acg aga acc tet tea tcc tgg ccc tg tc cgc 1219 Pro His Pro Lys Thr Thr Arg Thr Ser Ser Ser Trp Ser Gln Tyr Pro 360 365 370 ccg atg tet cca ttg gtc acg ggt ccg ctt acg gag aag aat ctg here 1267 e Pro Met Ser Pro Leu Val Thr Gly Pro Leu Thr Glu Lys Asn Leu Thr 375 380 385 tgg tgg gcc gga tcg cac tagcagcagt ggctcaaatt ggg 1308 Trp Trp Wing Gly Ser Gln 390 395 < 210 > 242 < 211 > 395 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 242 Met Thr Lys Wing Val Val He Gly Gly Gly Leu Wing Gly Leu Wing Thr 1 5 10 15 Thr Wing Leu Leu Arg Glu Gly Tyr Glu Val His Leu Val Glu Gln 20 25 30 Asn Glu His Leu Gly Gly Arg Wing Gly Thr Phe Glu Leu Asp Gly Phe 35 40 45 Arg Trp Asp Thr Gly Pro Ser Trp Tyr Leu Met Pro Asp Ala Met Ser 50 55 60 His Phe Phe Lys Leu Cys Gly Thr Ser He Asp Asp His Leu Asp Leu 65 70 75 80 Val Pro Leu Glu Pro Wing Tyr Arg Val He Asp Asp His Gly Glu Phe 85 90 95 He Asp Val Thr Ser Asp He Asp Wing Met Wing Glu Leu Phe Glu Ser 100 105 110 Arg Glu Pro Gly Wing Gly Wing Lys Leu Arg Thr Tyr He Asp Be Wing 115 120 125 Thr Gln Val Tyr Asn Leu Wing He Asp Gly Phe Leu Tyr Thr Asn Phe 130 135 140 Thr Asn Phe He Pro Tyr Leu Ser Pro Gly Met Leu Arg Leu Leu Pro 145 150 155 160 Lys Leu Leu Ala Ser Leu Be Thr Ser Leu Lys Val Lys Val Asn Thr 165 170 175 Gln Phe Arg Asp Thr Lys Leu Arg Gln He Leu Ser Tyr Pro Wing Val 180 185 190 Phe Leu Ser Ser Asp Pro Ser His Thr Pro Ala Leu Tyr His Leu Met 195 200 205 S er His Thr Asp Leu Val Gln Gly Val Ser Tyr Pro Arg Gly Gly Phe 210 215 220 Thr Wing Phe He Lys Wing Leu He Ser Leu He Asp Asp Wing Val Leu 225 230 235 240 His Leu Gly Thr Pro Val Ser Wing He Thr Thr Gln Gly Arg Asn Wing 245 250 255 Thr Gly Val Gln Val Gly Ser Glu Phe He Glu Wing Asp He Val He 260 265 270 Ser Cys Wing Asp Gln His His Thr Glu Thr Gln Leu Leu Pro Wing Ser 275 280 285 Leu Cys Ala Lys Pro Glu Thr Ser Trp Lys Asn Lys Gln Pro Gly Leu 290 295 300 Ser Thr Val Leu Val Leu Wing Gly Val Lys Gly Glu His Thr Leu Leu 305 310 315 320 Phe Pro Pro Thr Gly Thr Lys He Ser Wing Lys Phe Ser Thr Wing Pro 325 330 335 Pro Gln Asn Ser Arg Leu Gln Asn Pro Ser Arg Ser Pro Arg Pro Pro 340 345 350 Gln Gln Pro Pro Met Pro Pro Lys Wing Thr Arg Thr Ser Ser Ser 355 360 365 1 ,- ? ».« ?? Trp Ser Gln Tyr Pro Pro Met Ser Pro Leu Val Thr Gly Pro Leu Thr 370 375 380 Glu Lys Asn Leu Thr Trp Trp Wing Gly Ser Gln 385 390 395 < 210 > 243 < 211 > 450 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (427) < 223 > RXA01293 < 400 > 243 cggaaggcc cccgaaggcc acgagaacct cttcatcctg gtcccagtac ccgccgatgt 60 ctccattggt cacgggtccg cttacggaga agaatctgac atg gtg ggc cgg ate 115 Met Val Gly Arg He 1 5 gca ata gca gca gtg gct ca ggg cga tgg ggg tg ggc att gat ggt 163 Ala He Ala Ala Ala Ala Gln He Gly Arg Trp Ala Gly He Asp Gly 10 15 20 ttg gaa age cgc att gtt gtg cag cgc acc ate ggc ect gcc gac ttc 211 Leu Glu Be Arg He Val Val Gln Arg Thr He Gly Pro Wing Asp Phe 25 30 35 gca gac cga tac aac tcc tgg age ggc ggg tcc att ggc ccc tea falls 259 Wing Asp Arg Tyr Asn Ser Trp Ser Gly Gly Ser He Gly Pro Ser His 40 45 50 acc ctg gca cac tcg gcg ttc ttt agg ggt tet aac aaa tcc cgc aaa 307 Thr Leu Wing Gln Being Wing Phe Phe Arg Gly Being Asn Lys Being Arg Lys 55 60 65 gta gat ggc ctg tat gac gca ggt gac acc here gtt cca ggg gtg ggc 355 Val Asp Gly Leu Tyr Asp Wing Gly Asp Thr Thr Val Pro Gly Val Gly 70 75 80 85 gta tet atg tgt ttg ate tet gca gaa aac gtg etc aag cgt etc cgc 403 Val Ser Met Cys Leu He Ser Wing Glu Asn Val Leu Lys Arg Leu Arg 90 95 100 ggg gac aac agt gtg gat cgg act taacgggact tttttctttt gct 450 Gly Asp Asn Ser Val Asp Arg Thr 105 < 210 > 244 < 211 > 109 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 244 Met Val Gly Arg He Wing He Wing Wing Val Wing Gln He Gly Arg Trp 1 . 5 10 15 Wing Gly He Asp Gly Leu Glu Be Arg He Val Val Gln Arg Thr He 20 25 30 Gly Pro Wing Asp Phe Wing Asp Arg Tyr Asn Ser Trp Ser Gly Gly Ser 35 40 45 He Gly Pro Ser His Thr Leu Ala Gln Be Ala Phe Phe Arg Gly Ser 50 55 60 Asn Lys Ser Arg Lys Val Asp Gly Leu Tyr Asp Wing Gly Asp Thr Thr 65 70 75 80 Val Pro Gly Val Gly Val Ser Met Cys Leu He Ser Wing Glu Asn Val 85 90 95 Leu Lys Arg Leu Arg Gly Asp Asn Ser Val Asp Arg Thr 100 105 < 210 > 245 < 211 > 1386 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1363) < 223 > RXA02310 < 400 > 245 gaaatgg; here, aaaaigctttt tgtttaaccig tatgtcg; ACGG aaggeaettg; aagcaccttg 60 ggt-tagti Ctt lcttgctcticc ggactgagai z aatggggttt gtg tet here act ttt 115 Val Ser Thr Thr Phe 1 May gat gtg ttg ate ate ggc gcg ggc ccc tea ggt gcc age gcc gcc gtc 163 Asp Val Leu He He Gly Wing Gly Pro Ser Gly Wing Wing Wing Val 10 15 20 cat gcg gcc agg act ggg ctt cat here ttg ctt ate gac gcc tcc tcc 211 His Ala Wing Arg Thr Gly Leu Gln Thr Leu Leu He Asp Ala Ser Ser 25 30 35 ttc ccg cgg gat aaa acg tgt ggc gat ggc ctt act ccc cgt gcg att 259 Phe Pro Arg Asp Lys Thr Cys Gly Asp Gly Leu Thr Pro Arg Ala He 40 45 50 falls cag cta gaa ctt cta ggt gtt gct gat gg cag gtt acc ggg gat tat 307 His Gln Leu Glu Leu Leu Gly Val Wing Asp Gln Val Thr Gly Asp Tyr 55 60 65 tcc aac aac ggc ttg aaa ctg cat ggt ttt ggt ggt tet gtt gtt gag gcg 355 Phe Asn Lys Gly Leu Lys Leu His Gly Phe Gly Gly Ser Val Glu Wing 70 75 80 85 ccg tgg ccg gag here tat ttc acg aat aag ggt tcc gcg atg tcg cgg 403 Pro Trp Pro Glu Thr Tyr Phe Thr Asn Lys Gly Ser Wing Met Ser Arg 90 95 100 atg gag ttc gat gat ttg tta tcc cgc ttg gca aaa tet cat gag gaa 451 Met Glu Phe Asp Lep Leu Phe Arg Leu Ala Lys Ser His Glu Glu 105 110 115 gta acc acg tgg gag aac gcg age gcc ca gac ccc att ttg agg ggg 499 Val Thr Thr Trp Glu Asn Wing Wing Gln Asp Pro He Leu Arg Gly 120 125 130 aat ttc ttg gaa ggc gtt gtg att aat falls gca ggg ca gag aaa acc 547 Asn Phe Leu Glu Gly Val Val He Asn His Wing Gly Gln Glu Lys Thr 135 140 145 gtc aag gcg aag cat gtg att att gcc gat ggt gtc cgc tcc ect ttc 595 Val Lys Ala Lys His Val He He Wing Asp Gly Val Arg Ser Pro Phe 150 155 160 165 ggt aaag aaa ctg ggt agg cag tgg cag cgc gat gag gtg tat ggc att 643 Gly Lys Lys Leu Gly Arg Gln Trp Gln Arg Asp Glu Val Tyr Gly He 170 175 180 gcg gct cgt gct tat tgt gaa act ccg ctg tet gat gaa ccg tgg att 691 Ala Ala Arg Ala Tyr Cys Glu Thr Pro Leu Ser Asp Glu Pro Trp He 185 190 195 ** & * - »» * tcc cat cat gtg gaa ctg cgc gat gaa gat ggt gtg gtg cag cca gga 739 His Ser His Val Glu Leu Arg Asp Glu Asp Gly Val Val Gln Pro Gly 200 205 210 tat ggg tgg att ttc ccg ctg ggc aac ggc acg gtg aat ttg ggt tgt 787 Tyr Gly Trp He Phe Pro Leu Gly Asn Gly Thr Val Asn Leu Gly Cys 215 220 225 ggc gcg etc tcg acg gat acg aga cca gcg aag ate aat acg aag aaa 835 Gly Ala Leu Ser Thr Asp Thr Arg Pro Wing Lys He Asn Thr Lys Lys 230 235 240 245 • ttg ttg age ttc tat gcg ggt cag cgt cgt aaa gca tgg caa etc ggg Leu Leu Ser Phe Tyr Wing Gly Gln Arg Arg Lys Wing Trp Gln Leu Gly 250 255 260 ccc gag drops gac gtc gcc tet gcc ctg ctg ect atg ggc ggc gcg gtg 931 Pro Glu His Asp Val Ala Be Ala Leu Leu Pro Met Gly Gly Ala Val 265 270 275 tcg aat gtg gct ggc gcg aac tgg atg ctg ate ggc gat tcc gcc gcg 979 Be Asn Val Ala Gly Ala Asn Trp Met Leu He Gly Asp Be Ala Ala 280 285 290 tgt gtg aac ccg ctg aac ggc gaa ggc ate gac tat ggc ctg gaa acc 1027 Cys Val Asn Pro Leu Asn Gly Glu Gly He Asp Tyr Gly Leu Glu Thr 10 295 300 305 gcg gcg atg gcc gtc gac acg ctt gtg gaa aac ccc aag cgc gat ttg 1075 Wing Wing Met Wing Val Asp Thr Leu Val Glu Asn Pro Lys Arg Asp Leu 310 315 320 325 • acc ttg gta tgg cca cat agg ttg cgc gac gcg tac ggc gag acc ttc 1123 Thr Leu Val Trp Pro His Arg Leu Arg Asp Wing Tyr Gly Glu Thr Phe 330 335 340 atg ttg gcg cgc acg gct gct cga ctg ctg acg tac ccg cag ttt ttg 1171 Met Leu Ala Arg Thr Ala Ala Arg Leu Leu Thr Tyr Pro Gln Phe Leu 345 350 355 ccg atg gct ggg ccg etc gca ttc cgc ggg ccg ctg caa aag gcc ate 1219 Pro Met Ala Gly Pro Leu Ala Phe Arg Gly Pro Leu Gln Lys Ala He 15 360 365 370 atg ccg gcg gcg cgt tgc atg ggc aac ctg ate here gag gag gat 1267 Met Pro Wing Wing Wing Arg Leu Met Gly Asn Leu He Thr Glu Glu Asp 375 380 385 aaa gac ctg etc gcc agg ggt tgg cag gcc gcc gga tcc gcg att agt 1315 Lys Asp Leu Leu Wing Arg Gly Trp Gln Wing Wing Gly Ser Wing Ser 390 395 400 405 tgg gcg cgg aag ggc tcc ect ctg tgg gac tcg act agt tet ctg gtt 1363 Trp Wing Arg Lys Gly Ser Pro Leu Trp Asp Ser Thr Ser Ser Leu Val 410 415 420 taat: cgccga gtgcaigcgcg acg 1386 20 < 210 > 246 < 211 > 421 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 246 Val Ser Thr Thr Phe Asp Val Leu He He Gly Wing Gly Pro Ser Gly 1 5 10 15 Wing Wing Wing Wing Val His Wing Wing Arg Thr Gly Leu Gln Thr Leu Leu 20 25 30 He Asp Wing Being Ser Phe Pro Arg Asp Lys Thr Cys Gly Asp Gly Leu 35 40 45 25 Thr Pro Arg Ala He His Gln Leu Glu Leu Leu Gly Val Wing Asp Gln L.l t. * "._ • __. e «i 50 55 60 Val Thr Gly Asp Tyr Phe Asn Lys Gly Leu Lys Leu His Gly Phe Gly 65 70 75 80 Gly Ser Val Glu Ala Pro Trp Pro Glu Thr Tyr Phe Thr Asn Lys Gly 85 90 95 Ser Ala Met Ser Arg Met Glu Phe Asp Asp Leu Leu Phe Arg Leu Ala 100 105 110 Lys Ser His Glu Glu Val Thr Thr Trp Glu Asn Ala Be Ala Gln Asp • 115 120 125 Pro He Leu Arg Gly Asn Phe Leu Glu Gly Val Val He Asn His Wing 130 135 140 Gly Gln Glu Lys Thr Val Lys Wing Lys His Val He He Wing Asp Gly 145 150 155 160 Val Arg Ser Pro Phe Gly Lys Lys Leu Gly Arg Gln Trp Gln Arg Asp 165 170 175 Glu Val Tyr Gly He Ala Wing Arg Wing Tyr Cys Glu Thr Pro Leu Ser 180 185 190 Asp Glu Pro Trp He His Ser His Val Glu Leu Arg Asp Glu Asp Gly 195 200 205 Val Val Gln Pro Gly Tyr Gly Trp He Phe Pro Leu Gly Asn Gly Thr 10 210 215 220 Val Asn Leu Gly Cys Gly Ala Leu Ser Thr Asp Thr Arg Pro Ala Lys 225 230 235 240 He Asn Thr Lys Lys Leu Leu Ser Phe Tyr Wing Gly Gln Arg Arg Lys 245 250 255 Wing Trp Gln Leu Gly Pro Glu His Asp Val Wing Wing Wing Leu Leu Pro 260 265 270 Met Gly Gly Wing Val Ser Asn Val Wing Ala Gly Ala Trp Met Leu He 275 280 285 Gly Asp Ser Wing Wing Cys Val Asn Pro Leu Asn Gly Glu Gly He Asp 290 295 300 Tyr Gly Leu Glu Thr Wing Wing Met Wing Val Asp Thr Leu Val Glu Asn 15 305 310 315 320 Pro Lys Arg Asp Leu Thr Leu Val Trp Pro His Arg Leu Arg Asp Wing 325 330 335 Tyr Gly Thr Phe Met Leu Wing Arg Thr Wing Wing Arg Leu Leu Thr 340 345 350 Tyr Pro Gln Phe Leu Pro Met Wing Gly Pro Leu Wing Phe Arg Gly Pro 355 360 365 Leu Gln Lys Wing He Met Pro Pro Wing Wing Arg Leu Met Gly Asn Leu 370 375 380 He Thr Glu Glu Asp Lys Asp Leu Leu Wing Arg Gly Trp Gln Wing Ala 385 390 395 400 Gly Ser Ala Be Ser Trp Ala Arg Lys Gly Pro Pro Leu Trp Asp Ser 20 405 410 415 Thr Ser Ser Leu Val 420 < 210 > 247 < 211 > 1170 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1147) 25 < 223 > RXA02718 . »^ Ik? i. < 400 > 247 tccaccaaaa ttca, gec ge atccccctat te, gattgaag gac, gtctiect tgagcagttt 60 cgatgcccat gaccttgacc tcgacaaatt tcggaggtc gtg cga gat cgt ttg 115 Val Arg Asp Arg Leu 1 5 acg cag ttc etc gat gct ca gag cta here att gct gat ate ggc gct 163 Thr Gln Phe Leu Asp Wing Gln Glu Leu Thr He Wing Asp He Gly Wing 10 15 20 • ect gtc here gat gct gtg gcc cat ctt cgc agt ttc gtg etc aat gga 211 Pro Val Thr Asp Ala Val Ala His Leu Arg Ser Phe Val Leu Asn Gly 25 30 35 gga aag cga ate cgt ect ctt tat gcg tgg gct ggt ttc ctg gcg gcg 259 Gly Lys Arg He Arg Pro Leu Tyr Wing Trp Wing Gly Phe Leu Wing Wing 40 45 50 ca ggc cat aag aat tet tet gaa aaa ctt gag tcc gtc ctt gac gcc 307 Gln Gly His Lys Asn Ser Ser Glu Lys Leu Glu Ser Val Leu Asp Wing 55 60 65 gca gcg agt etc gaa ttc ate cag gct tgt gcc ttg att cat gac gat 355 Ala Ala Ser Leu Glu Phe He Gln Ala Cys Ala Leu He His Asp Asp 10 70 75 80 85 att ate gat tet tet gat acc cgg cgc gga gcc ccc here gtt cae cgg 403 He He Asp Being Ser Asp Thr Arg Arg Gly Wing Pro Thr Val His Arg 90 95 100 • gct gtg gaa gct gat fall cgc gcc aat aat ttc gaa ggc gat ccc gag 451 Wing Val Glu Wing Asp His Arg Wing Asn Asn Phe Glu Gly Asp Pro Glu 105 110 115 fall ttt ggc gtt tea gtc tcg att ttg gct ggc gat atg gca ttg gtg 499 His Phe Gly Val Ser Val Ser He Leu Ala Gly Asp Met Ala Leu Val 120 125 130 tgg gca gaa gac atg ctg cag gat tcc ggt ttg agt gca gag gca ttg 547 Trp Wing Glu Asp Met Leu Gln Asp Ser Gly Leu Ser Wing Glu Wing Leu 15 135 140 145 gcc cgc acg agg gat gct tgg cgt ggc atg cgt act gag gtt att ggc 595 Wing Arg Thr Arg Asp Wing Trp Arg Gly Met Arg Thr Glu Val He Gly 150 155 160 165 ggc cag ctg ctt gat att tat cta gag tcg drops gcc aac gag tcg gtg 643 Gly Gln Leu Leu Asp He Tyr Leu Glu Ser His Wing Asn Glu Ser Val 170 175 180 gag ctt gcg gat tet gtc aac cgc ttc aaa acg gcc gct tac acg att 691 Glu Leu Ala a • Asp Ser Val Asn Arg Phe Lys Thr Al Wing Tyr Thr He 185 190 195 gcg cgc cca ttg falls ctg ggc gcc tcc att gct ggc ggt tcg ccg cag 739 Wing Arg Pro Leu His Leu Gly Wing Be He Wing Gly Gly Ser Pro Gln 20 200 205 210 ctt ate gac gcg etc etc fall tac ggc fall gac ate ggc att gca ttc 787 Leu He Asp Ala Leu Leu His Tyr Gly His Asp He Gly He Wing Phe 215 220 225 cag ttg agg gat gat ctg ctt ggt gtg ttt ggg gat ccc gct ate acc 835 Gln Leu Arg Asp Asp Leu Leu Gly Val Phe Gly Asp Pro Wing He Thr 230 235 240 245 ggc aaa cca gct gga gac gat ate cgt gaa ggc aag cgc act gtt ctt 883 Gly Lys Pro Wing Gly Asp Asp He Arg Glu Gly Lys Arg Thr Val Leu 250 255 260 ctt gcg etc gct cta ca cc gct gat aag caa tet ect gaa gct gca 931 Leu Ala Leu Ala Leu Gln Arg Ala Asp Lys Gln Ser Pro Glu Ala Ala 25 265 270 275 to? > i __ i, acg gcc att cgc gca ggt gtt gga aag gtg act tea cca gaa gat att 979 Thr Ala He Arg Ala Gly Val Gly Lys Val Thr Ser Pro Glu Asp He 280 285 290 gct gtc att here gag cat att cga gct act ggt gct gaa gaa gaa gtt 1027 Ala Val He Thr Glu His He Arg Ala Thr Gly Ala Glu Glu Val Glu 295 300 305 gag cag cga att tcc cag ctg act gaa tcc ggt ttg gct falls etc gat 1075 Glu Gln Arg He Ser Gln Leu Thr Glu Ser Gly Leu Ala His Leu Asp 310 315 320 325 gat gta gac ate ccc gat gag gtg cgc gca cag ttg cgg gca ctg gct 1123 Asp Val Asp He Pro Asp Glu Val Arg Ala Gln Leu Arg Ala Leu Ala 330 335 340 ate cgc tea acc gaa cgt cgg atg tagtagaege gtatgacact ttt 1170 He Arg Be Thr Glu Arg Arg Met 345 < 210 > 248 < 211 > 349 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 248 Val Arg Asp Arg Leu Thr Gln Phe Leu Asp Wing Gln Glu Leu Thr He 1 5 10 15 Wing Asp He Gly Wing Pro Val Thr Asp Wing Val Wing His Leu Arg Ser 20 25 30 Phe Val Leu Asn Gly Gly Lys Arg He Arg Pro Leu Tyr Wing Trp Wing 35 40 45 Gly Phe Leu Wing Wing Gln Gly His Lys Asn Ser Ser Glu Lys Leu Glu 50 55 60 Ser Val Leu Asp Wing Wing Wing Leu Glu Phe He Gln Wing Cys Wing 65 70 75 80 Leu He His Asp Asp As Asp Ser Asp Thr Arg Arg Gly Wing 85 90 95 Pro Thr Val His Arg Wing Val Glu Wing Asp His Arg Wing Asn Asn Phe 100 105 110 Glu Gly Asp Pro Glu His Phe Gly Val Ser Val Ser He Leu Wing Gly 115 120 125 Asp Met Wing Leu Val Trp Wing Glu Asp Met Leu Gln Asp Ser Gly Leu 130 135 140 Ser Wing Glu Wing Leu Wing Arg Thr Arg Asp Wing Trp Arg Gly Met Arg 145 150 155 160 Thr Glu Val He Gly Gly Gln Leu Leu Asp He Tyr Leu Glu Ser His 165 170 175 Wing Asn Glu Ser Val Glu Leu Wing Asp Ser Val Asn Arg Phe Lys Thr 180 185 190 Wing Wing Tyr Thr Wing Wing Arg Pro Leu His Leu Gly Wing Wing He Wing 195 200 205 Gly Gly Ser Pro Gln Leu He Asp Ala Leu Leu His Tyr Gly His Asp 210 215 220 He Gly He Wing Phe Gln Leu Arg Asp Asp Leu Leu Gly Val Phe Gly 225 230 235 240 Asp Pro Wing He Thr Gly Lys Pro Wing Gly Asp Asp He Arg Glu Gly 245 250 255 Lys Arg Thr Val Leu Leu Ala Leu Ala Leu Gln Arg Ala Asp Lys Gln 260 265 270 Ser Pro Glu Ala Ala Thr Ala He Arg Ala Gly Val Gly Lys Val Thr 275 280 285 Ser Pro Glu Asp He Ala Val He Thr Glu His He Arg Ala Thr Gly 290 295 300 Wing Glu Glu Glu Val Glu Gln Arg He Ser Gln Leu Thr Glu Ser Gly 305 310 315 320 Leu Ala His Leu Asp Asp Val Asp He Pro Asp Glu Val Arg Ala Gln 325 330 335 Leu Arg Ala Leu Ala He Arg Ser Thr Glu Arg Arg Met 340 345 • <; 210 > 249 < 211 > 852 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (829) < 223 > RXA01067 10 < 400 > 249 ggctttaagg ccgaggtgcc tggctgaact gcagcccctc cagaccctga gatcaggcta 60 aatggcaaac acaaatagtt tgcatggcag aatagcttag gtg agt gaa ttc caa 115 Val Ser Glu Phe Gln • 1 5 gta ccc gaa ate ect gcc cata tcc cta cag aag cat att gcg ctt gtc 163 Val Pro Glu He Pro Ala Gln Phe Leu Pro Lys His He Wing Leu Val 10 15 20 atg gat gga aat gga cgc tgg gct acc gag cgt ggc atg aag cgc acc 211 Met Asp Gly Asn Gly Arg Trp Wing Thr Glu Arg Gly Met Lys Arg Thr 25 30 35 gaa ggc cat aag cgt ggc gag gtc gtc ctg gat gtt gtt gat gca 259 15 Glu Gly His Lys Arg Gly Glu Wing Val Leu Leu Asp Val Val Asp Wing 40 45 50 tgc att gaa ctt ggt gtt ccg tac ctt tet gct tat gcc ttc tet act 307 Cys He Glu Leu Gly Val Pro Tyr Leu Ser Wing Tyr Wing Phe Ser Thr 55 60 65 gaa aac tgg cgt cgt tcc acc gat gag gtc cgt ttc etc atg gga ttc 355 Glu Asn Trp Arg Arg Ser Thr Asp Glu Val Arg Phe Leu Met Gly Phe 70 75 80 85 aac cga gat gtg ctg cga cga cca c gc gat gac cta cat gaa aag ggc 403 • Asn Arg Asp Val Leu Arg Arg Gln Arg Asp Asp Leu His Glu Lys Gly 90 95 100 gtt cgt gtg cgt tgg gtt ggc cgt cgt ccc cgc ctg tgg cgt tcg gtt 451 20 Val Arg Val Arg Trp Val Gly Arg Arg Pro Arg Leu Trp Arg Ser Val 105 110 115 ate cgt gag ctg gaa act gcg gaa gag cta acc aaa gac aac acc acc 499 He Arg Glu Leu Glu Thr Wing Glu Glu Leu Thr Lys Asp Asn Thr Thr 120 125 130 atg acc ttg gcc atg tgt gtg aac tat ggt gga cgc gcc gaa ate ate 547 Met Thr Leu Ala Met Cys Val Asn Tyr Gly Gly Arg Ala Glu He He 135 140 145 gac gca gcc cgc gac ate gcc cgc ctt gca gct gaa ggc aaa ctc cgc 595 Asp Ala Ala Arg Asp He Ala Arg Leu Ala Ala Glu Gly Lys Leu Arg 150 155 160 165 ccg gaa caa ate act gag aag acc ttc ccg aac ttc etc gac gaa ect 643 25 Pro Glu Gln He Thr Glu Lys Thr Phe Pro Ashen Phe Leu Asp Glu Pro 170 175 180 gac atg cca gac gtc gac ctg ttc ctg cgc cca ccc ccc ggt gag aag cgc 691 Asp Met Pro Asp Val Asp Leu Phe Leu Arg Pro Ser Gly Glu Lys Arg 185 190 195 acg aac ttc ctg ctg tgg cag tet gcc tac gcg gaa atg gtc tac 739 Thr Ser Asn Phe Leu Leu Trp Gln Ser Wing Tyr Wing Glu Met Val Tyr 200 205 210 caa gac aag ctg ttc ect gat ttc acg cag ca gt gat gt gcg 787 Gln Asp Lys Leu Phe Pro Asp Phe Thr Gln Gln Asp Leu Tyr Asp Wing • 215 220 225 gtc ctg gaa tac gcc aag cgg cgc aga tc gga age gca 829 Val Leu Glu Tyr Ala Lys Arg Asp Arg Arg Phe Gly Ser Ala 230 235 240 taatgcccac caaccagccg acg 852 < 210 > 250 < 211 > 243 < 212 > PRT < 213 > Corynebacterium glutamicum 10 < 400 > 250 Val Ser Glu Phe Gln Val Pro Glu He Pro Wing Gln Phe Leu Pro Lys 1 5 10 15 His He Wing Leu Val Met Asp Gly Asn Gly Arg Trp Wing Thr Glu Arg # 20 25 30 Gly Met Lys Arg Thr Glu Gly His Lys Arg Gly Glu Wing Val Leu Leu 35 40 45 Asp Val Val Asp Wing Cys He Glu Leu Gly Val Pro Tyr Leu Ser Wing 50 55 60 Tyr Wing Phe Ser Thr Glu Asn Trp Arg Arg Ser Thr Asp Glu Val Arg 65 70 75 80 Phe Leu Met Gly Phe Asn Arg Asp Val Leu Arg Arg Gln Arg Asp Asp 15 85 90 95 Leu His Glu Lys Gly Val Arg Val Arg Trp Val Gly Arg Arg Pro Arg 100 105 110 Leu Trp Arg Ser Val He Arg Glu Leu Glu Thr Ala Glu Glu Leu Thr 115 120 125 Lys Asp Asn Thr Thr Met Thr Leu Wing Met Cys Val Asn Tyr Gly Gly 130 135 140 Arg Wing Glu He He Asp Wing Wing Arg Asp He Wing Arg Leu Wing Wing 145 150 155 160 • Glu Gly Lys Leu Arg Pro Glu Gln He Thr Glu Lys Thr Phe Pro Asn 165 170 175 Phe Leu Asp Glu Pro Asp Met Pro Asp Val Asp Leu Phe Leu Arg Pro 20 180 185 190 Ser Gly Glu Lys Arg Thr Ser Asn Phe Leu Leu Trp Gln Ser Ala Tyr 195 200 205 Wing Glu Met Val Tyr Gln Asp Lys Leu Phe Pro Asp Phe Thr Gln Gln 210 215 220 Asp Leu Tyr Asp Wing Val Leu Glu Tyr Wing Lys Arg Asp Arg Arg Phe 225 230 235 240 Gly Ser Wing < 210 > 251 < 211 > 564 < 212 > DNA 2 < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (541) < 223 > RXA01269 < 400 > 251 gattatctct < gcgccgattc agctggcaait ageageagtt gtattgagag < rtcal: ggtcg 60 tccgattcta -tttecgtcaac cacgacctgg ga; aagacggt gtg gta ttt gag atg 115 Val Val Phe Glu Met 1 5 att aag ttt cga acc atg ctt gaa cca gat gaa aaa cat gta act gat 163 He Lys Phe Arg Thr Met Leu Glu Pro Asp Glu Lys His Val Thr Asp 10 15 20 gaa cag cgt cta act aaa gtt gga aag ctt ctg cgg gaa acg agt tta 211 Glu Gln Arg Leu Thr Lys Val Gly Lys Leu Leu Arg Glu Thr Ser Leu 25 30 35 gat gag tta ect here etc tgg aat gta ttt aaa ggt gat atg age ctt 259 Asp Glu Leu Pro Thr Leu Trp Asn Val Phe Lys Gly Asp Met Ser Leu 40 45 50 cat tac tet tet 307 10 gta ggg ect cga ect ttg ctt gtt age tat ctg gaa Val Gly Pro Arg Pro Leu Leu Val Ser Tyr Leu Glu His Tyr Ser Ser 55 60 65 gaa ca gct gg cgc cat gaa gtt cgt ect ggg att act ggt ttg gct 355 • Glu Gln Ala Arg Arg His Glu Val Arg Pro Gly He Thr Gly Leu Wing 70 75 80 85 cag gtg aat ggc cgt aat ca act act tgg gat gaa cga ctt aag ttg 403 Gln Val Asn Gly Arg Asn Gln Thr Thr Trp Asp Glu Arg Leu Lys Leu 90 95 100 gat gtc gaa tat gtg gat cgc tgt agt ttg aaa cta gat ttc aaa ata 451 Asp Val Glu Tyr Val Asp Arg Cys Ser Leu Lys Leu Asp Phe Lys He 105 110 115 15 tta ate gcc act gta aaa here gtt ctt tet aaa aag ggc att agt aat 499 Leu He Wing Thr Val Lys Thr Val Leu Ser Lys Lys Gly He Ser Asn 120 125 130 gaa ggt cat gtc acg atg cca tcc ttc att gaa gaa aga aaa 541 Glu Gly His Val Thr Met Pro Ser Phe He Glu Glu Arg Lys 135 140 145 tagcaggtaa aaattttact ttc 564 • < 210 > 252 < 211 > 147 < 212 > PRT < 213 > Corynebacterium glutamicum 20 < 400 > 252 Val Val Phe Glu Met He Lys Phe Arg Thr Met Leu Glu Pro Asp Glu 1 5 10 15 Lys His Val Thr Asp Glu Gln Arg Leu Thr Lys Val Gly Lys Leu Leu 20 25 30 Arg Glu Thr Ser Leu Asp Glu Leu Pro Thr Leu Trp Asn Val Phe Lys 35 40 45 Gly Asp Met Ser Leu Val Gly Pro Arg Pro Leu Leu Val Ser Tyr Leu 50 55 60 Glu His Tyr Ser Ser Glu Gln Ala Arg Arg His Glu Val Arg Pro Gly 65 70 75 80 25 He Thr Gly Leu Wing Gln Val Asn Gly Arg Asn Gln Thr Thr Trp Asp 85 90 95 Glu Arg Leu Lys Leu Asp Val Glu Tyr Val Asp Arg Cys Ser Leu Lys 100 105 110 Leu Asp Phe Lys He Leu He Wing Thr Val Lys Thr Val Leu Ser Lys 115 120 125 Lys Gly He Ser Asn Glu Gly His Val Thr Met Pro Ser Phe He Glu 130 135 140 Glu Arg Lys 145 • < 210 > 253 < 211 > 554 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (531) < 223 > RXA01205 < 400 > 253 10 gta tcg gcc tat ccg ccg gcc ate ate gca gcg gct etc gta gga att 48 Val Ser Wing Tyr Pro Pro Wing He Wing Wing Wing Wing Leu Val Gly He 1 5 10 15 • tgc gcg gga gtt ttg ccc cat aat ttt gaa ccc tcg cga ata ttt atg 96 Cys Ala Gly Val Leu Pro His Asn Phe Glu Pro Ser Arg He Phe Met 20 25 30 ggc gat tcc ggc tcc atg etc ate ggc ctg ctg ttg gct gca gca tcg 144 Gly Asp Ser Gly Ser Met Leu He Gly Leu Leu Leu Wing Wing Ala Ser 35 40 45 acc gcg tea tea gga aaa ate aac atg age ctg tat ggc gca gct gat 192 Thr Ser Wing Being Gly Lys He Asn Met Being Leu Tyr Gly Wing Wing Asp 50 55 60 15 ttt ate gca ttg ate tea ccc ate ate gtt gtt etc gcc gcc gtg gcc 240 Phe He Wing Leu He Ser Pro He He Val Val Leu Wing Wing Val Wing 65 70 75 80 ate cca ctg etc gac etc gtg atg gca gtg gtt agg cgc gtg ggc agg 288 He Pro Leu Leu Asp Leu Val Met Wing Val Val Arg Arg Val Gly Arg 85 90 95 gga gca tea ccc ttt tcc ccg gac aaa atg cat ctg falls drops cga cg 336 Gly Wing Ser Pro Phe Ser Pro Asp Lys Met His Leu His His Arg Leu • 100 105 110 ctg tcc ate gga drops acc cat agg cgc gtg gtc cta gtg etc tac acc 384 Leu Ser He Gly His Thr His Arg Arg Val Val Leu Val Leu Tyr Thr 115 120 125 20 tgg gcg age gcc gtg gca ttc ggc gca gtg age ttc tcc gtc gtt ccg 432 Trp Wing Be Wing Val Wing Phe Gly Wing Val Ser Phe Ser Val Val Pro 130 135 140 cca ctg ttt gcc acc gga tcg age ate tgt ggc ate etc ate gcc gtc 480 Pro Leu Phe Wing Thr Gly Be Being He Cys Gly He Leu He Wing Val 145 150 155 160 gct gtc here gcc gtg cca gtg atg aaa age cgg cga gcc gcc aaa ctt 528 Ala Val Thr Ala Val Pro Val Met Lys Ser Arg Arg Ala Ala Lys Leu 165 170 175 gat taagtgattg tcactttgga ttg 554 Asp 25 - «- aaB» - < 210 > 254 < 211 > 177 < 212 > PRT < 213 >; Corynebacterium glutamicum < 400 > 254 Val Ser Ala Tyr Pro Pro Ala He Ala Ala Ala Ala Val Gly He 1 5 10 15 Cys Ala Gly Val Leu Pro His Asn Phe Glu Pro Ser Arg He Phe Met 20 25 30 Gly Asp Ser Gly Ser Met Leu He Gly Leu Leu Leu Wing Wing Ala Ser 35 40 45 Thr Ser Wing Be Gly Lys He Asn Met Be Leu Tyr Gly Wing Wing Asp 50 55 60 Phe He Wing Leu He Ser Pro He He Val Val Leu Ala Wing Val Wing 65 70 75 80 He Pro Leu Leu Asp Leu Val Met Ala Val Val Arg Arg Val Gly Arg 85 90 95 Gly Wing Ser Pro Phe Ser Pro Asp Lys Met His Leu His His Arg Leu 10 100 105 110 Leu Ser He Gly His Thr His Arg Arg Val Val Leu Val Leu Tyr Thr 115 120 125 Trp Wing Be Wing Val Wing Phe Gly Wing Val Ser Phe Ser Val Val Pro • 130 135 140 Pro Leu Phe Wing Thr Gly. Being Ser He Cys Gly He Leu He Wing Val 145 150 * 155 160 Ala Val Thr Ala Val Pro Val Met Lys Ser Arg Arg Ala Ala Lys Leu 165 170 175 Asp < 210 > 255 15 < 211 > 882 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (859) < 223 > RXA01576 • < 400 > 255 atcggtgatc tttegegatt gatacgtgcg cgattgcgtg cccgccagct getcaagate 60 aatggatttc atgacaatca agttatcatc actggggtcg gtg gca ect aac agg 115 20 Val Ala Pro Asn Arg 1 5 aaa ate age cat cat gca cta ggc tet att ect ate atg gat gca tea 163 Lys He Ser His His Wing Leu Gly Ser He Pro He Met Asp Wing Ser 10 15 20 aaa aac age gac ttt aaa gac acc tgg cta gtc gta ect tgt tat aac 211 Lys Asn Ser Asp Phe Lys Asp Thr Trp Leu Val Val Pro Cys Tyr Asn 25 30 35 gag gca here gtt ate cgg gaa gtt tta gag aac gca etc aaa here ttc 259 Glu Ala Thr Val He Arg Glu Val Leu Glu Asn Ala Leu Lys Thr Phe 40 45 50 ect aat att gtt gcg gtc aac gat ggc tcc ccg gac aac tcc gcg gaa 307 25 Pro Asn He Val Wing Val Asn Asp Gly Ser Pro Asp Asn Ser Wing Glu 55 60 65 gaa ate cat gcg gcc ggc gca falls ctg gtc aac falls ccc gtg aac etc. 355 Glu He His Wing Wing Gly Wing His Leu Val Asn His Pro Val Asn Leu 70 75 80 85 gga ca gg gcc gcg ate ca g acc ggc ate gaa tac gcc cgc aag caa 403 Gly Gln Gly Wing Wing Gln Thr Gly He Glu Tyr Wing Arg Lys Gln 90 95 100 ccc ggt gca aaa tac ttt gta act tcc gac gcc gac ggc caá cae ca 451 Pro Gly Wing Lys Tyr Phe Val Thr Phe Asp Wing Asp Gly Gln His Gln • 105 110 115 gtg aaa gac gtt ate cgc atg gtg gag cga ctg cgt gcc gag gac gtg 499 Val Lys Asp Val He Arg Met Val Glu Arg Leu Arg Ala Glu Asp Val 120 125 130 gac att ate gtc ggc acg cgt ttt gga cgc ccacgc cac gcc gat gac 547 Asp He He Val Val Gly Thr Arg Phe Gly Arg Pro Arg Gln Wing Asp Asp 135 140 145 cag gtg cca cta c a cc a cc c gc c gc gc gc gc gc gc ccg 595 Gln Val Pro Leu He Lys Arg Leu Val Leu Arg Thr Val Val Leu Leu 150 155 160 16.5 tea ccg aaa acc cgc cga ctt ggg etc acc gac gcc falls aac ggc ctg 643 10 Ser Pro Lys Thr Arg Arg Leu Gly Leu Thr Asp Ala His Asn Gly Leu 170 175 180 cgc gta ttc aac caa aaa gtg gcg cag gaa atg aac ate cgc atg aac 691 Arg Val Phe Asn Gln Lys Val Wing Gln Glu Met Asn He Arg Met Asn 185 190 195 ggc atg tcg cat gca tcc gaa ate gtc gac ca a ate gat gaa cgc ggc 739 Gly Met Ser His Wing Ser Glu He Val Asp Gln He Asp Glu Arg Gly 200 205 210 tgg cgc att tea gaa gaa ccc gta gac ate etc tac acc gaa tac tcc 787 Trp Arg He Ser Glu Glu Pro Val. Asp He Leu Tyr Thr Glu Tyr Ser 215 220 225 atg age aag ggg cac tcc ctg etc aac ggc gta aac ate ctg gcc gac 835 15 Met Ser Lys Gly Gln Ser Leu Leu, Asn Gly Val Asn He Leu Wing Asp 230 235 240 245 ggc ttc cta gcg agg aga etc cca tgacgcagac caccacccaa ate 882 Gly Phe Leu Wing Arg Arg Leu Pro 250 < 210 > 256 < 211 > 253 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 256 20 Val Ala Pro Asn Arg Lys He Ser His His Wing Leu Gly Ser He Pro 1 5 10 15 He Met Asp Wing Ser Lys Asn Ser Asp Phe Lys Asp Thr Trp Leu Val 20 25 30 Val Pro Cys Tyr Asn Glu Wing Thr Val He Arg Glu Val Leu Glu Asn 35 40 45 Wing Leu Lys Thr Phe Pro Asn He Val Wing Val Asn Asp Gly Ser Pro 50 55 60 Asp Asn Ser Wing Glu Glu He His Wing Wing Gly Wing His Leu Val Asn 65 70 75 80 His Pro Val Asn Leu Gly Gln Gly Wing Wing He Gln Thr Gly He Glu 85 90 95 25 Tyr Wing Arg Lys Gln Pro Gly Wing Lys Tyr Phe Val Thr Phe Asp Wing I. : í 'Ji 100 105 110 Asp Gly Gln His Gln Val Lys Asp Val He Arg Met Val Glu Arg Leu 115 120 125 Arg Ala Glu Asp Val Asp He He Val Val Thr Arg Phe Gly Arg Pro 130 135 140 Arg Gln Ala Asp Asp Gln Val Pro Leu He Lys Arg Leu Val Leu Arg 145 150 155 160 Thr Val Val Leu Leu Ser Pro Lys Thr Arg Arg Leu Gly Leu Thr Asp 165 170 175 Wing His Asn Gly Leu Arg Val Phe Asn Gln Lys Val Wing Gln Glu Met 180 185 190 Asn He Arg Met Asn Gly Met Ser His Wing Ser Glu He Val Asp Gln 195 200 205 He Asp Glu Arg Gly Trp Arg He Ser Glu Glu Pro Val Asp He Leu 210 215 220 Tyr Thr Glu Tyr Ser Met Ser Lys Gly Gln Ser Leu Leu Asn Gly Val 225 230 235 240 Asn He Leu Wing Asp Gly Phe Leu Wing Arg Arg Leu Pro 245 250 10 < 210 > 257 < 211 > 1173 < 212 > DNA < 213 > Corynebacterium glutamicum • < 220 > < 221 > CDS < 222 > (101) .. (1150) < 223 > RXN02309 < 400 > 257 gtgccttccg tegactaegg ttaaacaaaa agctttttgt ccatttcact ggattcaccg 60 j aaagaatgaa tccacactcg atcaccaaag gtagcgatga atg agt age ggc cga 115 Met Be Ser Gly Arg 1 5 acc gtt cca acc cgt tcc falls ggg etc gga aaa gaa ggt gta tcc acc 163 Thr Val Pro Thr Arg Ser His Gly Leu Gly Lys Glu Gly Val Ser Thr 10 15 20 here gga gca tet cag gtc gag ttt ggt gat ccc gag cta acg gcc agg 211 Thr Gly Ala Ser Gln Val Glu Phe Gly Asp Pro Glu Leu Thr Ala Arg 25 30 35 • ate aat gac gcc atg gtg cag gta gaa gaa etc ctg falls act gaa cta 259 He Asn Asp Wing Met Val Gln Val Glu Glu Leu Leu His Thr Glu Leu 40 45 50 2Q tcg tcg ggg gaa gac ttc etc gtc gat ate gtc atg drops cta here cga 307 Ser Ser Gly Glu Asp Phe Leu Val Asp He Val Met His Leu Thr Arg 55 60 65 gcc ggc ggc aaa cga ct tc cgc atg ttt gca ctg ctg gcc tcc gag 355 Wing Gly Gly Lys Arg Phe Arg Pro Met Phe Wing Leu Leu Wing Ser Glu 70 75 80 85 ttc ggt gaa aaa cca etc tcc gaa aac gtc ate aaa gcc gcc gtt gtc 403 Phe Gly Glu Lys Pro Leu Ser Glu Asn Val He Lys Ala Wing Val Val 95 95 100 gta gag ate acc fall ctg gcc acc ctg tac falls gac gat gtc atg gac 451 Val Glu He Thr His Leu Ala Thr Leu Tyr His Asp Asp Val Met Asp 105 110 115 25 gag gca tcc atg cgc cgc ggc gtc cca agt gct aac gcg cga tgg gac 499 ^^ ¡^ j | || i > ? . _ > _ "Glu Ala Met Met Arg Arg Gly Val Pro Be Wing Asn Wing Arg Trp Asp 120 125 130 aac tcc gta gcc ate etc gca ggc gac ate etc cta gca cat gca tea 547 Asn Ser Val Ala He Leu Ala« ly Asp He Leu Leu Ala His Wing Ser 135 140 145 ggt ctg atg agt cag ctg ggt acc gac here gtc gcc falls ttt gcc gaa 595 Gly Leu Met Ser Gln Leu Gly Thr Asp Thr Val Wing His Phe Ala Glu 150 155 160 165 here ttc ggc gaa cta gtc acc ggc caa atg cgc gaa here gtc ggg cca 643 • Thr Phe Gly Glu Leu Val Thr Gly Gln Met Arg Glu Thr Val Gly Pro 170 175 180 cgc gac acc gac ccg ate gag cae tac acc aac gta ate cgt gaa aaa 691 Arg Asp Thr Asp Pro He Glu His Tyr Thr Asn Val He Arg Glu Lys 185 190 195 act ggt gtc etc ate gcc tcc gca ggc tat ttg gga gcc atg falls gca 739 Thr Gly Val Leu He Wing Wing Wing Gly Tyr Leu Gly Wing Met His Wing 200 205 210 ggc gcc gca ect gaa falls ate gac gcc ctg aag aac ttc ggc gc gcc 787 Gly Wing Wing Pro Glu His He Asp Wing Leu Lys Asn Phe Gly Wing Wing 215 220 225 10 gtc ggc atg ate ttc ca ate gtc gac gac ate ate gac ate ttc tcg 835 Val Gly Met He Phe Gln He Val Asp Asp He He Asp He Phe Ser 230 235 240 245 gaa acc falls gaa tcc gga aaa acg ccc ggc acc gac etc cgc gaa ggt 883 • Glu Thr His Glu Ser Gly Lys Thr Pro Gly Thr Asp Leu Arg Glu Gly 250 255 260 gta ttc acc etc cca gtg etc tac gca etc cgt gaa gac acc ccc gtc 931 Val Phe Thr Leu Pro Val Leu Tyr Ala Leu Arg Glu Asp Thr Pro Val 265 270 275 ggc gca gaa etc cgc gac ate etc acc ggc ect cta gaa gac gac gag 979 Gly Wing Glu Leu Arg Asp He Leu Thr Gly Pro Leu Glu Asp Asp Glu 280 285 290 15 acc gtc aac falls gtc etc gag etc. etc tcc ca gcc tc ggc gga cgc ca 1027 Thr Val Asn His Val Leu Glu Leu Leu Ser Gln Ser Gly Gly Arg Gln 295 300 305 gca gcc etc gac gag gc tac ccc tac atc gac ate gcc aac gca gaa 1075 Ala Ala Leu Asp Glu Val Tyr Arg Tyr Met Asp He Wing Asn Wing Glu 310 315 320 325 etc gac cgc etc cca gac age acc gtc aag gaa gcc etc cgc aac ctt 1123 Leu Asp Arg Leu Pro Asp Ser Thr Val Lys Glu Ala Leu Arg Asn Leu 330 335 340 • gca acc ttc here gtc aag cgc gtc gga taaccccgta atccaccact 1170 Wing Thr Phe Thr Val Lys Arg Val Gly 345 350 20 taa 1173 < 210 > 258 < 211 > 350 < 212 > PRT < 213 > Coryneibact: erium glutamicum < 400 > 258 Met Being Ser Gly Arg Thr Val Pro Thr Arg Being His Gly Leu Gly Lys 1 5 10 15 Glu Gly Val Being Thr Thr Gly Wing Being Gln Val Glu Phe Gly Asp Pro 20 25 30 25 Glu Leu Thr Wing Arg He Asn Asp Wing Met Val Gln Val Glu Glu Leu 35 40 45 Leu His Thr Glu Leu Ser Gly Glu Asp Phe Leu Val Asp He Val 50 55 60 Met His Leu Thr Arg Wing Gly Gly Lys Arg Phe Arg Pro Met Phe Wing 65 70 75 80 Leu Leu Wing Ser Glu Phe Gly Glu Lys Pro Leu Ser Glu Asn Val He 85 90 95 Lys Wing Wing Val Val Val Glu He Thr His Leu Wing Thr Leu Tyr His 100 105 110 • Asp Asp Val Met Asp Glu Wing Ser Met Arg Arg Gly Val Pro Ser Wing 115 120 125 Asn Wing Arg Trp Asp Asn Ser Val Wing He Leu Wing Gly Asp He Leu 130 135 140 Leu Wing His Wing Being Gly Leu Met Being Gln Leu Gly Thr Asp Thr Val 145 150 155 160 Wing His Phe Wing Glu Thr Phe Gly Glu Leu Val Thr Gly Gln Met Arg 165 170 175 Glu Thr Val Gly Pro Arg Asp Thr Asp Pro He Glu His Tyr Thr Asn 180 185 190 Val He Arg Glu Lys Thr Gly Val Leu He Wing Be Wing Gly Tyr Leu 10 195 200 205 Gly Wing Met His Wing Gly Wing Wing Pro Glu His He Asp Wing Leu Lys 210 215 220 Asn Phe Gly Wing Wing Val Gly Met He Phe Gln He Val Asp Asp He • 225 230 235 240 He Asp He Phe Ser Glu Thr His Glu Ser Gly Lys Thr Pro Gly Thr 245 250 255 Asp Leu Arg Glu Gly Val Phe Thr Leu Pro Val Leu Tyr Ala Leu Arg 260 265 270 Glu Asp Thr Pro Val Gly Ala Glu Leu Arg Asp He Leu Thr Gly Pro 275 280 285 Leu Glu Asp Asp Glu Thr Val Asn His Val Leu Glu Leu Leu Ser Gln 15 290 295 300 Ser Gly Gly Arg Gln Ala Ala Leu Asp Glu Val Tyr Arg Tyr Met Asp 305 310 315 320 He Wing Asn Wing Glu Leu Asp Arg Leu Pro Asp Ser Thr Val Lys Glu 325 330 335 Ala Leu Arg Asn Leu Ala Thr Phe Thr Val Lys Arg Val Gly 340 345 350 < 210 > 259 • < 211 >; 1075 < 212 > DNA < 213 > Corynebacterium glutamicum 20 < 220 > < 221 > CDS < 222 > (101) .. (1075) < 223 > FRXA02309 < 400 > 259 gtgccttccg tegactaegg ttaaacaaaa agctttttgt ccatttcact ggattcaccg 60 aaagaatgaa tccacactcg atcaccaaag gtagcgatga atg agt age ggc cga 115 Met Ser Gly Arg 1 5 acc gtt cca acc cgt tcc falls ggg etc gga aaa gaa ggt gta tcc acc 163 25 Thr Val Pro Thr Arg Ser His Gly Leu Gly Lys Glu Gly Val Ser Thr 10 15 20 here gga gca tet cag gtc gag ttt ggt gat ccc gag cta acg gcc agg 211 Thr Gly Ala Ser Gln Val Glu Phe Gly Asp Pro Glu Leu Thr Ala Arg 25 30 35 ate aat gac gcc atg gtg cag gta gaa gaa etc ctg falls act gata cta 259 He Asn Asp Ala Met Val Gln Val Glu Glu Leu Leu His Thr Glu Leu 40 45 50 tcg tdc ggg gaa gac ttc etc gtc gtc gat ate gtc atg cta cta here cga 307 Ser Ser Gly Glu Asp Phe Leu Val Asp He Val Met His Leu Thr Arg • 55 60 65 gcc ggc ggc aaa cga ttc cgc ccc atg ttt gca ctg ctg gcc tcc gag 355 Wing Gly Gly Lys Arg Phe Arg Pro Met Phe Ala Leu Leu Ala Ser Glu 70 75 80 85 ttc ggt gaa aaa cca etc tcc gaa aac gtc ate aaa gcc gct gtt gtc 403 Phe Gly Glu Lys Pro Leu Ser Glu A sn Val He Lys Wing Wing Val Val 90 95 100 gta gag ate acc fall ctg gcc acc ctg tac falls gac gat gtc atg gac 451 Val Glu He Thr His Leu Wing Thr Leu Tyr His Asp Asp Val Met Asp 105 110 115 gag gca tcc atg cgc cgc ggc gtc cca agt gct aac gcg cga tgg gac 499 10 Glu Wing Being Arg Arg Arg Gly Val Pro Be Wing Asn Wing Arg Trp Asp 120 125 130 aac tcc gta gcc ate etc gca ggc gac ate etc cta gca cat gca tea 547 Asn Ser Val Ala He Leu Ala Gly Asp He Leu Leu Ala His Ala Ser • 135 140 145 ggt ctg atg agg cag ctg ggt acc gac here gtc gcc falls ttt gcc gaa 595 Gly Leu Met Ser Gln Leu Gly Thr Asp Thr Val Ala Wing Phe Ala Glu 150 155 160 165 here ttc ggc gaa cta gtc acc ggc cag atg cgc gaa here gtc ggg cca 643 Thr Phe Gly Glu Leu Val Thr Gly Gln Met Arg Glu Thr Val Gly Pro 170 175 180 cgc gac acc gac ccg ate gag falls tac acc aac gta ate cgt gaa aaa 691 15 Arg Asp Thr Asp Pro He Glu His Tyr Thr Asn Val He Arg Glu Lys 185 190 195 act ggt gtc etc ate gcc tcc gca ggc tat ttg gga gcc atg falls gca 739 Thr Gly Val Leu He Wing Wing Wing Gly Tyr Leu Gly Wing Met His Wing 200 205 210 ggc gcc gca ect gaa falls ate gac gcc ctg aag aac ttc ggc gca gcc 787 Gly Ala Ala Pro Glu His He Asp Ala Leu Lys Asn Phe Gly Ala Ala 215 220 225 gtc ggc atg ate ttc ca ate gtc gac gac ate ate gac ate ttc tcg 835 • Val Gly Met He Phe Gln He Val Asp Asp He He Asp He Phe Ser 230 235 240 245 gaa acc falls gaa tcc gga aaa acg ccc ggc acc gac etc cgc gaa ggt 883 20 Glu Thr His Glu Ser Gly Lys Thr Pro Gly Thr Asp Leu Arg Glu Gly 250 255 260 gta ttc acc etc cca gtg etc tac gca etc cgt gaa gac acc ccc gtc 931 Val Phe Thr Leu Pro Val Leu Tyr Ala Leu Arg Glu Asp Thr Pro Val 265 270 275 ggc gca gaa etc cgc gac tie etc ggc ect cta gaa gac gac gag 979 Gly Wing Glu Leu Arg Asp He Leu Thr Gly Pro Leu Glu Asp Aslu Glu 280 285 290 gtc aac falls gtc etc gag etc etc tcc cd tg ggc gga cgc ca 1027 Thr Val Asn His Val Leu Glu Leu Leu Ser Gln Ser Gly Gly Arg Gln 295 300 305 gca gcc etc gac gag gtc tac cgc tac atg gac ate gcc aac gca gaa 1075 25 Ala Ala Leu Asp Glu Val Tyr Arg Tyr Met Asp He Ala Asn Ala Glu , -! .. * ..; , i k ,, i 310 315 320 325 < 210 > 260 < 211 > 325 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 260 Met Being Ser Gly Arg Thr Val Pro Thr Arg Being His Gly Leu Gly Lys • 1 5 10 15 Glu Gly Val Ser Thr Thr Gly Ala Ser Gln Val Glu Phe Gly Asp Pro 20 25 30 Glu Leu Thr Wing Arg He Asn Asp Wing Met Val Gln Val Glu Glu Leu 35 40 45 Leu His Thr Glu Leu Ser Gly Glu Asp Phe Leu Val Asp He Val 50 55 60 Met His Leu Thr Arg Wing Gly Gly Lys Arg Phe Arg Pro Met Phe Wing 65 70 75 80 Leu Leu Wing Ser Glu Phe Gly Glu Lys Pro Leu Ser Glu Asn Val He 85 90 95 10 Lys Wing Wing Val Val Val Glu He Thr His Leu Wing Thr Leu Tyr His 100 105 110 Asp Asp Val Met Asp Glu Wing Ser Met Arg Arg Gly Val Pro Ser Wing 115 120 125 • Asn Wing Arg Trp Asp Asn Ser Val Wing He Leu Ala Gly Asp He Leu 130 135 140 Leu Ala His Wing Ser Gly Leu Met Ser Gln Leu Gly Thr Asp Thr Val 145 150 155 160 Wing His Phe Wing Glu Thr Phe Gly Glu Leu Val Thr Gly Gln Met Arg 165 170 175 Glu Thr Val Gly Pro Arg Asp Thr Asp Pro He Glu His Tyr Thr Asn 180 185 190 15 Val He Arg Glu Lys Thr Gly Val Leu He Wing Ser Wing Gly Tyr Leu 195 200 205 Gly Wing Met His Wing Gly Wing Wing Pro Glu His He Asp Ala L eu Lys 210 215 220 Asn Phe Gly Wing Wing Val Gly Met He Phe Gln He Val Asp Asp He 225 230 235 240 He Asp He Phe Ser Glu Thr His Glu Ser Gly Lys Thr Pro Gly Thr 245 250 255 Asp Leu Arg Glu Gly Val Phe Thr Leu Pro Val Leu Tyr Ala Leu Arg • 260 265 270 Glu Asp Thr Pro Val Gly Ala Glu Leu Arg Asp He Leu Thr Gly Pro 275 280 285 20 Leu Glu Asp Asp Glu Thr Val Asn His Val Leu Glu Leu Leu Ser Gln 290 295 300 Ser Gly Gly Arg Gln Ala Ala Leu Asp Glu Val Tyr Arg Tyr Met Asp 305 310 315 320 He Wing Asn Ala Glu 325 < 210 > 261 < 211 > 1767 < 212 > DNA < 213 > Corynebacterium glutamicum 25 < 220 > < 221 > CDS < 222 > (101). . (1744) < 223 > RXN00477 < 400 > 261 tgcgggagcg aatcagagtt ccacttcata tcaaactctc tacactcgct agagccacga 60 tgaaaggtct atctatgagc atctacagaa agaattcgtg atg aag gtc tcg act 115 Met Lys Val Ser Thr 1 5 aaa act cca cgc tcc tea ggt acc gcc gta gtc ata ggc gca ggt gtt 163 Lys Thr Pro Arg Ser Ser Gly Thr Wing Val Val He Gly Wing Gly Val 10 15 20 gct ggt tta gcc act tet gca ctt tta gca cgt gat ggc tgg ca gta 211 Wing Gly Leu Wing Thr Ser Wing Leu Leu Wing Arg Asp Gly Trp Gln Val 25 30 35 act gtt ttg gaa aaa aat act gat gtc ggt ggc cga gct gga tcg ctt 259 Thr Val Leu Glu Lys Asn Thr Asp Val Gly Gly Arg Ala Gly Ser Leu 40 45 50 gaa ata ata ggc ttt ect ggc ttt cga tgg gat acc action gga ect tet tgg 307 Glu He Ser Gly Phe Pro Gly Phe Arg Trp Asp Thr Gly Pro Ser Trp 55 60 65 tac etc atg ccc gacc gcc ttt gac cat ttc tcc gca ctt ttt ggt gca 355 Tyr Leu Met Pro Glu Wing Phe Asp His Phe Phe Wing Leu Phe Gly Wing 70 75 80 85 tgt act tet gat tat etc gat ttg gta gata tta acg ect ggt tat cga 403 Cys Thr Ser Asp Tyr Leu Asp Leu Val Glu Leu Thr Pro Gly Tyr Arg 90 95 100 gtt ttt tet ggc here cat gac gct gtc gat gtc ccc act ggg cgt gaa 451 Val Phe Ser Gly Thr His Asp Ala Val Asp Val Pro Thr Gly Arg Glu 105 110 115 gaa gca att gcg cta ttc gaa tcc ate gaa ccc ggc g cg ggt gca aaa 499 Glu Ala He Ala Leu Phe Glu Ser He Glu Pro Gly Ala Gly Ala Lys 120 125 130 cta gga aat tat ctt gat age gcg gca gac gcc tat gac att gcc att 547 Leu Gly Asn Tyr Leu Asp Ser Ala Ala Asp Ala Tyr Asp He Ala He 135 140 145 gat aga ttc ctt tat aat aat ttc tcc acg tta ggc ccg ctg ctt falls 595 Asp Arg Phe Leu Tyr Asn Asn Phe Ser Thr Leu Gly Pro Leu Leu His 150 155 160 165 cgg gat gta ctg acc cga gct ggc cg ctg ttt tet cta ctg acc cgt 643 Arg Asp Val Leu Thr Arg Ala Gly Arg Leu Phe Ser Leu Leu Thr Arg 170 175 180 tet tta ca a a ta ta gta aat agt ca a ttc agt age ccg gtg ttg cgc 691 Ser Leu Gln Lys Tyr Val Asn Ser Gln Phe Ser Ser Pro Val Leu Arg 185 190 195 cag ate cta acc tat cca gca gtc ttc ctg tet tcc cga ccc act act 739 Gln He Leu Thr Tyr Pro Wing Val Phe Leu Ser Ser Arg Pro Thr Thr 200 205 210 acc cca tcg atg tac falls ttg atg agt cat acc gat ttg gtg cag gga 787 Thr Pro Ser Met Tyr His Leu Met Ser His Thr Asp Leu Val Gln Gly 215 220 225 gtg aaa tac ect ata ggt ggt gtt ttt act gca gtg gtt aac gct ctg cat 835 Val Lys Tyr Pro He Gly Gly Phe Thr Wing Val Val Asn Ala Leu His 230 235 240 245 cag tta gcg ctg gaa aac ggg gtt gag ttt caa etc gat tet gag gtc 883 Gln Leu Ala Leu Glu Asn Gly Val Glu Phe Gln Leu Asp Ser Glu Val 250 255 260 att tcc ate aac act gct tea tcg agg ggc aac here age gcc here ggt 931 He Ser He Asn Thr Ala Ser Ser Arg Gly Asn Thr Ser Ala Thr Gly 265 270 275 gtg age ttg ctt falls aac aga aga gtg caa aat cta gat gcg gat ctt 979 Val Ser Leu Leu His Asn Arg Lys Val Gln Asn Leu Asp Wing Asp Leu 280 285 290 gtg gtt tea gca ggc gac cta falls cat here gaa aat aat ctg ctt ccc 1027 Val Val Ser Ala Gly Asp Leu His His Thr Glu Asn Asn Leu Leu Pro 295 300 305 • cgg gaa ctt cga cga acc tat ccc gaga cga tat tgg tcc aat cgc aat ect 1075 Arg Glu Leu Arg Thr Tyr Pro Glu Arg Tyr Trp Ser Asn Arg Asn Pro 310 315 320 325 gga att gga gcg gta tta ate etc ctg ggc gta aaa gga gag tta ccc 1123 Gly He Gly Wing Val Leu He Leu Leu Gly Val Lys Gly Glu Glu Leu Pro 330 335 340 cag etc gac cat falls aac ctt ttc ttc agt gaa gat tgg here gat gat 1171 Gln Leu Asp His Asn Leu Phe Phe Ser Glu Asp Trp Thr Asp Asp 345 350 355 ttt gct gta gtt ttc gac ggg ect cact ctt acc cgc ccc falls aat gca 1219 Phe Ala Val Val Phe Asp Gly Pro Gl n Leu Thr Arg Pro His Asn Wing 360 365 370 10 tea aat tcc att tat gtc tcc aag ect tea acg tcc gaa gac ggc gtt 1267 Ser Asn Ser He Tyr Val Ser Lys Pro Ser Thr Ser Glu Asp Gly Val 375 380 385 gca ect gct gga tac gaa aac ctt ttt gtt tta att ccg acc aag gcc 1315 Wing Pro Wing Gly Tyr Glu Asn Leu Phe Val Leu He Pro Thr Lys Wing 390 395 400 405 tet age age ate ggc falls ggt gat gcg tat atg cag tcg gct tea gca 1363 Being Ser Gly His Gly Asp Wing Tyr Met Gln Ser Wing Being Wing 410 415 420 tcc gtg gaa here gcg tea cat gca ate aat caat att gct acg caa 1411 Ser Val Glu Thr He Ala Ser His Wing He Asn Gln He Wing Thr Gln 425 430 435 15 gcc ggc ate ect gac etc act gac cga att gtg gtc aaa cgc acc att 1459 Wing Gly He Pro Asp Leu Thr Asp Arg He Val Val Lys Arg Thr He 440 445 450 ggc ect gcg gat ttt gag falls cgc tac cat tea tgg gta ggc ag gcg 1507 Gly Pro Wing Asp Phe Glu His Arg Tyr His Ser Trp Val Gly Ser Wing 455 460 465 ctg ggt cca gca cat acc etc aga cag tcc gct ttc tta aga ggg cg c 1555 Leu Gly Pro Wing His Thr Leu Arg Gln Wing Wing Phe Leu Arg Gly Arg 470 475 480 485 aat age tc cgc aag gtc aat aac etc ttc tat tcc ggt gcc acc acc 1603 Asn Ser Ser Arg Lys Val Asn Asn Leu Phe Tyr Ser Gly Wing Thr Thr 490 495 500 20 gtc cg ggt gta gta ata ccc atg tgt tta att tet gcc gag aat att 1651 Val Pro Gly Val Gly He Pro Met Cys Leu He Ser Wing Glu Asn He 505 510 515 att aag cgt tta cat gcc gat acc agt gca gca cca cca ccc gaa cca 1699 He Lys Arg Leu His Wing Asp Thr Ser Wing Gly Pro Leu Pro Glu Pro 520 525 530 ttg ccg ect aaa acg here cca tet caa aag acc tea tac gat cat 1744 Leu Pro Pro Lys Thr Thr Pro Ser Gln Lys Thr Ser Tyr Asp His 535 540 545 taaattttga tccctatcat cga 1767 25 < 210 > 262 ^ a ^^ jHttígj < 211 > 548 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 262 Met Lys Val Ser Thr Lys Thr Pro Arg Ser Ser Gly Thr Wing Val Val 1 5 10 15 He Gly Wing Gly Val Wing Gly Leu Wing Thr Ser Wing Leu Leu Wing Arg 20 25 30 • Asp Gly Trp Gln Val Thr Val Leu Glu Lys Asn Thr Asp Val Gly Gly 35 40 45 Arg Wing Gly Ser Leu Glu He Ser Gly Phe Pro Gly Phe Arg Trp Asp 50 55 60 Thr Gly Pro Ser Trp Tyr Leu Met Pro Glu Wing Phe Asp His Phe Phe 65 70 75 80 Ala Leu Phe Gly Ala Cys Thr Ser Asp Tyr Leu Asp Leu Val Glu Leu 85 90 95 Thr Pro Gly Tyr Arg Val Phe Ser Gly Thr His Asp Ala Val Asp Val 100 105 110 Pro Thr Gly Arg Glu Glu Ala He Ala Leu Phe Glu Ser He Glu Pro 10 115 120 125 Gly Wing Gly Wing Lys Leu Gly Asn Tyr Leu Asp Being Wing Wing Asp Wing 130 135 140 Tyr Asp He Wing He Asp Arg Phe Leu Tyr Asn Asn Phe Ser Thr Leu • 145 150 155 160 Gly Pro Leu Leu His Arg Asp Val Leu Thr Arg Ala Gly Arg Leu Phe 165 170 175 Ser Leu Leu Thr Arg Ser Leu Gln Lys Tyr Val Asn Ser Gln Phe Ser 180 185 190 Ser Pro Val Leu Arg Gln He Leu Thr Tyr Pro Wing Val Phe Leu Ser 195 200 205 Ser Arg Pro Thr Thr Thr Pro Ser Met Tyr His Leu Met Ser His Thr 15 210 215 220 Asp Leu Val Gln Gly Val Lys Tyr Pro He Gly Gly Phe Thr Wing Val 225 230 235 240 Val Asn Ala Leu His Gln Leu Ala Leu Glu Asn Gly Val Glu Phe Gln 245 250 255 Leu Asp Ser Glu Val He Ser He Asn Thr Ala Ser Ser Arg Gly Asn 260 265 270 Thr Ser Ala Thr Gly Val Ser Leu Leu His Asn Arg Lys Val Gln Asn 275 280 285 Leu Asp Wing Asp Leu Val Val Ser Wing Gly Asp Leu His His Thr Glu 290 295 300 Asn Asn Leu Leu Pro Arg Glu Leu Arg Thr Tyr Pro Glu Arg Tyr Trp 20 305 310 315 320 Ser Asn Arg Asn Pro Gly He Gly Wing Val Leu He Leu Leu Gly Val 325 330 335 Lys Gly Glu Leu Pro Gln Leu Asp His His Asn Leu Phe Phe Ser Glu 340 345 350 Asp Trp Thr Asp Asp Phe Wing Val Val Phe Asp Gly Pro Gln Leu Thr 355 360 365 Arg Pro His Asn Wing Ser Asn Ser He Tyr Val Ser Lys Pro Ser Thr 370 375 380 Ser Glu Asp Gly Val Wing Pro Wing Gly Tyr Glu Asn Leu Phe Val Leu 385 390 395 400 He Pro Thr Lys Wing Being Ser Gly His Gly Asp Wing Tyr Met 25 405 410 415 k- f -? ^, iaki. * Gln Being Wing Being Wing Being Wing Val Glu Thr Wing Wing His Wing He Asn 420 425 430 Gln He Wing Thr Gln Wing Gly He Pro Asp Leu Thr Asp Arg He Val 435 440 445 Val Lys Arg Thr He Gly Pro Wing Asp Phe Glu His Arg Tyr His Ser 450 455 460 Trp Val Gly Ser Wing Leu Gly Pro Wing His Thr Leu Arg Gln Ser Wing 465 470 475 480 Phe Leu Arg Gly Arg Asn Being Ser Arg Lys Val Asn Asn Leu Phe Tyr 485 490 495 Ser Gly Wing Thr Thr Val Pro Gly Val Gly He Pro Met Cys Leu He 500 505 510 Ser Wing Glu Asn He He Lys Arg Leu His Wing Asp Thr Ser Ala Gly 515 520 525 Pro Leu Pro Glu Pro Leu Pro Pro Lys Thr Pro Ser Gln Lys Thr 530 535 540 Ser Tyr Asp His 545 < 210 > 263 < 211 > 1767 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1744) < 223 > FRXA00477 < 400 > 263 tgcigggagcg, aatcagagtt ccacttcat; a tcaaactctc tacactetgct; agagecaega 60 tga, aaggtct, atet; atgagc atetacagaa agaattcgtg atg aag gtc tcg act 115 Met Lys Val Ser Thr 1 5 aaa act cca cgc tcc tea ggt acc gcc gta gtc ata ggc gca ggt gtt 163 Lys Thr Pro Arg Ser Ser Gly Thr Wing Val Val He Gly Wing Gly Val 10 15 20 gct ggt tta gcc act tet gca ctt tta gca cgt gat ggc tgg ca gta 211 Ala Gly Leu Ala Thr Ser Ala Leu Leu Ala Arg Asp Gly Trp Gln Val 25 30 35 act gtt ttg gaa aaa aat act gat gtc ggt ggc cga gct gga tcg ctt 259 Thr Val Leu Glu Lys Asn Thr Asp Val Gly Gly Arg Wing Gly Ser Leu 40 45 50 gaa ata ata ggc ttt ect ggc ttt cga tgg gat acc gga ect tet tgg 307 Glu He Ser Gly Phe Pro Gly Phe Arg Trp Asp Thr Gly Pro Ser Trp 55 60 65 tac etc atg ccc gac gcc ttt gac cat ttc ttc gca ctt ttt ggt gca 355 Tyr Leu Met Pro Glu Ala Phe Asp His Phe Phe Ala Leu Phe Gly Ala 70 75 80 85 tgt act tet gat tat etc gat ttg gta gaa tta acg ect ggt tat cga 403 Cys Thr Ser Asp Tyr Leu Asp Leu Val Glu Leu Thr Pro Gly Tyr Arg 90 95 100 gtt ttt tet ggc here cat gac gct gtc gat gtc ccc act ggg cgt gaa 451 Val Phe Ser Gly Thr His Asp Ala Val Asp Val Pro Thr Gly Arg Glu 105 110 115 gaa gca att gcg cta ttc gaa tcc ate gaa ccc ggc gcg ggt gca aaa 499 Glu Ala He Ala Leu Phe Glu Ser He Glu Pro Gly Ala Gly Ala Lys 120 125 130 cta gga aat tat ctt gat age gcg gca gac gcc tat gac att gcc att 547 Leu Gly Asn Tyr Leu Asp Ser Ala Ala Asp Ala Tyr Asp He Ala He 135 140 145 gat aga ttc ctt tat aat aat ttc tcc acg tta ggc ccg ctg ctt falls 595 Asp Arg Phe Leu Tyr Asn Asn Phe Ser Thr Leu Gly Pro Leu Leu His 150 155 160 165 cgg gat gta ctg acc cga gct ggc cga ctg ttt tet cta ctg acc cgt 643 Arg Asp Val Leu Thr Arg Wing Gly Arg Leu Phe Ser Leu Leu Thr Arg 170 175 180 tet tta caa aag tac gta aat agt caa ttc agt age ccg gtg ttg cgc 691 Ser Leu Gln Lys Tyr Val Asn Ser Gln Phe Be Pro Pro Val Leu Arg 185 190 195 cag ate cta acc tat cca gca gtc ttc ctg tet tcc cga ccc act act 739 Gln He Leu Thr Tyr Pro Wing Val Phe Leu Ser Ser Arg Pro Thr Thr 200 205 210 acc cca tcg atg tac falls ttg atg agt cat acc gat ttg gtg cag gga 787 Thr Pro Ser Met Tyr His Leu Met Ser His Thr Asp Leu Val Gln Gly 215 220 225 gtg aaa tac ect ata ggt ggt ttt act gca gtg gtt aac gct ctg cat 835 10 Val Lys Tyr Pro He Gly Gly Phe Thr Wing Val Val Asn Ala Leu His 230 235 240 245 cag tta gcg ctg gaa aac ggg gtt gag ttt caa etc gat tet gag gtc 883 Gln Leu Ala Leu Glu Asn Gly Val Glu Phe Gln Leu Asp Ser Glu Val • 250 255 260 att tcc ate aac act gct tcg agg ggc aac aca gcc ggt 931 He Ser He Asn Thr Ala Ser Being Arg Gly Asn Thr Ser Ala Thr Gly 265 270 275 gtg age ttg ctt falls aac aga aaa gtg caat aat cta gat gcg gat ctt 979 Val Ser Leu Leu His Asn Arg Lys Val Gln Asn Leu Asp Wing Asp Leu 280 285 290 gtg gtt tea gca ggc gac cta falls cat here gaa aat aat ctg ctt ccc 1027 15 Val Val Ser Ala Gly Asp Leu His His Thr Glu Asn Asn Leu Leu Pro 295 300 305 cgg gaa ctt cga acc tat ccc gaga cga tat tgg tcc aat cgc aat ect 1075 Arg Glu Leu Arg Thr Tyr Pro Glu Arg Tyr Trp Ser Asn Arg Asn Pro 310 315 320 325 gga att gga gcg gta tta ate etc ctg ggc gta aaa gga gag tta ccc 1123 Gly He Gly Wing Val Leu He Leu Leu Gly Val Lys Gly Glu Leu Pro 330 335 340 cag etc gac cat falls gaa gat • aac ctt ttc ttc agt tgg here gat gat 1171 Gln Leu Asp His His Asn Leu Phe Phe Ser Glu Asp Trp Thr Asp Asp 345 350 355 ttt gct gtt ttc gac ggg ect cact ctt acc cgc ccc cae aat gca 1219 20 Phe Wing Val Val Phe Asp Gly Pro Gln Leu Thr Arg Pro His Asn Wing 360 365 370 tea aat tcc att tat gtc tcc aag ect tea acg tcc gaa gac ggc gtt 1267 Ser Asn Be He Tyr Val Ser Lys Pro Ser Thr Ser Glu Asp Gly Val 375 380 385 gca ect gct gga tac gaa aac ctt ttt gtt tta att ccg acc aag gcc 1315 Wing Pro Wing Gly Tyr Glu Asn Leu Phe Val Leu He Pro Thr Lys Wing 390 395 400 405 tet age age ate ggc falls ggt gat gcg tat atg cag tcg gct tea gca 1363 Being Being He Gly His Gly Asp Wing Tyr Met Gln Being Wing Being Wing 410 415 420 tcc gtg gaa here gcg tea cat gca ate aat caat att gct acg caa 1411 25 Ser Val Glu Thr He Ala Ser His Wing He Asn Gln He Wing Thr Gln 425 430 435 gcc ggc ate ect gac etc act gac cga att gtg gtc aaa cgc acc att 1459 Wing Gly He Pro Asp Leu Thr Asp Arg He Val Val Lys Arg Thr He 440 445 450 ggc ect gcg gat ttt gag falls cgc tac cat tea tgg gta ggc agt gcg 1507 Gly Pro Wing Asp Phe Glu His Arg Tyr His Ser Trp Val Gly Ser Wing 455 460 465 ctg ggt cca gca cat acc etc aga cag tcc gct ttc tta aga ggg cgc 1555 Leu Gly Pro Wing His Thr Leu Arg Gln Being Wing Phe Leu Arg Gly Arg 470 475 480 485 aat age tcc cgc aag gtc aat aac etc ttc tat tcc ggt gcc acc acc 1603 Asn Ser Ser Arg Lys Val Asn Asn Leu Phe Tyr Ser Gly Wing Thr Thr 490 495 500 gtc ccg ggt gta gga ata ccc atg tgt tta att tet gcc gag aat att 1651 Val Pro Gly Val Gly He Pro Met Cys Leu He Ser Wing Glu Asn He 505 510 515 att aag cgt tta cat gcc gat acc agt gca gga cca ctg ccc gaa cca 1699 He Lys Arg Leu His Wing Asp Thr Ser Wing Gly Pro Leu Pro Glu Pro 520 525 530 ttg ccg ect aaa acg here cca tet caa aag acc e ta ta cat gat 1744 Leu Pro Pro Lys Thr Thr Pro Ser Gln Lys Thr Ser Tyr Asp His 535 540 545 taaattttga tccctatcat cga 1767 < 210 > 264 < 211 > 548 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 264 Met Lys Val Ser Thr Lys Thr Pro Arg Ser Ser Gly Thr Wing Val Val 1 5 10 15 He Gly Wing Gly Val Wing Gly Leu Wing Thr Ser Wing Leu Leu Wing Arg 20 25 30 Asp Gly Trp Gln Val Thr Val Leu Glu Lys Asn Thr Asp Val Gly Gly 35 40 45 Arg Wing Gly Ser Leu Glu He Ser Gly Phe Pro Gly Phe Arg Trp Asp 50 55 60 Thr Gly Pro Ser Trp Tyr Leu Met Pro Glu Wing Phe Asp His Phe Phe 65 70 75 80 Ala Leu Phe Gly Wing Cys Thr Ser Asp Tyr Leu Asp Leu Val Glu Leu 85 90 95 Thr Pro Gly Tyr Arg Val Phe Ser Gly Thr His Asp Ala Val Asp Val 100 105 110 Pro Thr Gly Arg Glu Glu Ala He Ala Leu Phe Glu Ser He Glu Pro 115 120 125 Gly Wing Gly Wing Lys Leu Gly Asn Tyr Leu Asp Ser Wing Wing Asp Wing 130 135 140 Tyr Asp He Wing He Asp Arg Phe Leu Tyr Asn Asn Phe Ser Thr Leu 145 150 155 160 Gly Pro Leu Leu His Arg Asp Val Leu Thr Arg Ala Gly Arg Leu Phe 165 170 175 Ser Leu Leu Thr Arg Ser Leu Gln Lys Tyr Val Asn Ser Gln Phe Ser 180 185 190 Ser Pro Val Leu Arg Gln He Leu Thr Tyr Pro Wing Val Phe Leu Ser 195 200 205 Being Arg Pro Thr Thr Thr Pro Being Met Tyr His Leu Met Being His Thr 210 215 220 Asp Leu Val Gln Gly Val Lys Tyr Pro He Gly Gly Phe Thr Wing Val 225 230 235 240 Val Asn Ala Leu His Gln Leu Ala Leu Glu Asn Gly Val Glu Phe Gln 245 250 255 Leu Asp Ser Glu Val He Ser He Asn Thr Wing Being Ser Arg Gly Asn 260 265 270 Thr Ser Wing Thr Gly Val Ser Leu Leu His Asn Arg Lys Val Gln Asn 275 280 285 • Leu Asp Ala Asp Leu Val Val Ser Wing Gly Asp Leu His His Thr Glu 290 295 300 Asn Asn Leu Leu Pro Arg Glu Leu Arg Thr Tyr Pro Glu Arg Tyr Trp 305 310 315 320 Ser Asn Arg Asn Pro Gly He Gly Wing Val Leu He Leu Leu Gly Val 325 330 335 Lys Gly Glu Leu Pro Gln Leu Asp His His Asn Leu Phe Phe Ser Glu 340 345 350 Asp Trp Thr Asp Asp Phe Wing Val Val Phe Asp Gly Pro Gln Leu Thr 355 360 365 Arg Pro His Asn Wing Ser Asn Ser He Tyr Val Ser Lys Pro Ser Thr 10 370 375 380 Ser Glu Asp Gly Val Wing Pro Wing Gly Tyr Glu Asn Leu Phe Val Leu 385 390 395 400 He Pro Thr Lys Wing Being Being He Gly His Gly Asp Wing Tyr Met • 405 410 415 Gln Being Wing Being Wing Being Val Glu Thr He Wing Being His Wing He Asn 420 425 430 Gln He Wing Thr Gln Wing Gly He Pro Asp Leu Thr Asp Arg He Val 435 440 445 Val Lys Arg Thr He Gly Pro Wing Asp Phe Glu His Arg Tyr His Ser 450 455 460 Trp Val Gly Ser Wing Leu Gly Pro Wing His Thr Leu Arg Gln Ser Wing 15 465 470 475 480 Phe Leu Arg Gly Arg Asn Being Ser Arg Lys Val Asn Asn Leu Phe Tyr 485 490 495 Ser Gly Wing Thr Thr Val Pro Gly Val Gly He Pro Met Cys Leu He 500 505 510 Ser Wing Glu Asn He He Lys Arg Leu His Wing Asp Thr Ser Wing Gly 515 520 525 Pro Leu Pro Glu Pro Leu Pro Pro Lys Thr Thr Pro Ser Gln Lys Thr 530 535 540 Ser Tyr Asp His 545 20 < 210 > 265 < 211 > 954 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (931) < 223 > RXA00478 < 400 > 265 accagaagea gcctcagcta tgacacacca aaattcgcct ctcttcctta aaagtgcact 60 25 gagaetttac aatcgggcct cattcaaggc ttcacataaa gtg ate gaa gaa tat 115 Val He Glu Glu Tyr 1 5 tcc acg age ttc agt ctg tet acg tgg ttg cta tcc cca cgc ata cga 163 Ser Thr Ser Phe Ser Leu Ser Thr Trp Leu Leu Ser Pro Arg He Arg 10 15 20 aat gac ata cga aat etc tat gca gta gtt cgt ate gcc gat gag att 211 Asn Asp He Arg Asn Leu Tyr Wing Val Val Arg He Wing Asp Glu He 25 30 35 gtc gac ggc act gca cat gcc gct ggt tgc tea act gcc aaa ate gaa 259 Val Asp Gly Thr Wing Ala Wing Wing Gly Cys Ser Thr Wing Lys He Glu 40 45 50 gag att etc gat gcc tat gaa att gcg gtt ctt gca gca cca ca ca caa 307 Glu He Leu Asp Ala Tyr Glu Wing Wing Val Leu Wing Wing Pro Gln Gln 55 60 65 cgc ttc aac here gat ctt gtt tta ca gct tat ggt gaa act gcc cga 355 Arg Phe Asn Thr Asp Leu Val Leu Gln Wing Tyr Gly Glu Thr Wing Arg 70 75 80 85 cgc tgt gat ttc gaa ca gaga cat gta ata gcc ttc ttt gca tea atg 403 Arg Cys Asp Phe Glu Gln Glu His Val He Ala Phe Phe Ala Ser Met 90 95 100 451 10 cgt aag gac etc aaa gct aat here falls gac cca gat age ttc here acg Arg Lys Asp Leu Lys Wing Asn Thr His Asp Pro Asp Ser Phe Thr Thr 105 110 115 tat gtc tat ggc tcc gcg gaa gtt ata ggc ctg ctt tgt etc age gtt 499 • Tyr Val Tyr Gly Ser Wing Glu Val He Gly Leu Leu Cys Leu Ser Val 120 125 130 ttc aac cag ggt aga acg att age aaa aaa cgg cta gag att atg caa 547 Phe Asn Gln Gly Arg Thr He Ser Lys Lys Arg Leu Glu He Met Gln 135 140 145 aac gga gcc cgc tea ttg gga gcg gca ttc cag aaa att aac ttt etc 595 Asn Gly Ala Arg Ser Leu Gly Ala Ala Phe Gln Lys He Asn Phe Leu 150 155 160 165 15 cgt gac ttg gca gaa gat cag caat aat ttg ggc cga ttt tat ttc ccc 643 Arg Asp Leu Wing Glu Asp Gln Gln Asn Leu Gly Arg Phe Tyr Phe Pro 170 175 180 aaa acc age ca gga act ctt act aaa gaa ca aaa gaa gat etc ate 691 Lys Thr Ser Gln Gly Thr Leu Thr Lys Glu Gln Lys Glu Asp Leu He 185 190 195 gct gat ate cgt caa gac cta gca att gcc falls gat gca ttt cca gaa 739 Wing Asp He Arg Gln Asp Leu Wing He Wing Asp Wing Phe Pro Glu 200 205 210 • ata cca gtg cag gct cgc ate gga gtg ate tet gct tat ttg etc ttt 787 He Pro Val Gln Ala Arg He Gly Val He Ser Ala Tyr Leu Leu Phe 215 220 225 20 caá aaa etc act gac cga att gag gct act ect acc gcc gat tta ttg 835 Gln Lys Leu Thr Asp Arg He Glu Wing Thr Pro Thr Wing Asp Leu Leu 230 235 240 245 cgg gag cga ate aga gtt cca ctt cat ate aaa etc tet here etc gct 883 Arg Glu Arg He Arg Val Pro Leu His He Lys Leu Ser Thr Leu Ala 250 255 260 aga gcc acg atg aaa ggt cta tet atg age ate tac aga aag aat tcg 931 Arg Ala Thr Met Lys Gly Leu Ser Met Ser He Tyr Arg Lys Asn Ser 265 270 275 tgat: gaaggt ctcgactaaa act 954 < 210 > 266 25 < 211 > 277 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 266 Val He Glu Glu Tyr Ser Thr Ser Phe Ser Leu Ser Thr Trp Leu Leu 1 5 10 15 Ser Pro Arg He Arg Asn Asp He Arg Asn Leu Tyr Wing Val Val Arg 20 25 30 He Wing Asp Glu He Val Asp Gly Thr Wing His Wing Wing Gly Cys Ser • 35 40 45 Thr Wing Lys He Glu Glu He Leu Asp Wing Tyr Glu He Wing Val Leu 50 55 60 Wing Wing Pro Gln Gln Arg Phe Asn Thr Asp Leu Val Leu Gln Wing Tyr 65 70 75 80 Gly Glu Thr Wing Arg Arg Cys Asp Phe Glu Gln Glu His Val He Wing 85 90 95 Phe Phe Wing Being Met Arg Lys Asp Leu Lys Wing Asn Thr His Asp Pro 100 105 110 Asp Ser Phe Thr Thr Tyr Val Tyr Gly Ser Wing Glu Val He Gly Leu 115 120 125 10 Leu Cys Leu Ser Val Phe Asn Gln Gly Arg Thr He Ser Lys Lys Arg 130 135 140 Leu Glu He Met Gln Asn Gly Wing Arg Ser Leu Gly Wing Wing Phe Gln 145 150 155 160 • Lys He Asn Phe Leu Arg Asp Leu Wing Glu Asp Gln Gln Asn Leu Gly 165 170 175 Arg Phe Tyr Phe Pro Lys Thr Ser Gln Gly Thr Leu Thr Lys Glu Gln 180 185 190 Lys Glu Asp Leu He Wing Asp He Arg Gln Asp Leu Wing He Wing His 195 200 2 05 Asp Wing Phe Pro Glu He Pro Val Gln Wing Arg He Gly Val He Ser 210 215 220 15 Wing Tyr Leu Leu Phe Gln Lys Leu Thr Asp Arg He Glu Wing Thr Pro 225 230 235 240 Thr Wing Asp Leu Leu Arg Glu Arg He Arg Val Pro Leu His He Lys 245 250 255 Leu Ser Thr Leu Wing Arg Wing Thr Met Lys Gly Leu Ser Met Ser He 260 265 270 Tyr Arg Lys Asn Ser 275 • <; 210 > 267 < 211 > 1056 < 212 > DNA 20 < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1033) < 223 > RXA01291 < 400 > 267 aacccgcagc gggtggagcg gggetgaggg agacgtcgag aagcgtccct ttcggttgtc 60 tggatttctc gcggtaaagt ttcctgtgaa ggaggcgagt gtg gct gat cag caa 115 Val Wing Asp Gln Gln 1 5 25 gat ttt ttg ggc cgt ttt gat gcg atg age tea aag gcg acg gcc acg 163 L airMtAríírML.

Asp Phe Leu Gly Arg Phe Asp Wing Met Ser Ser Lys Wing Thr Wing Thr 10 15 20 gta ate gcc cat tat tcc tcc agt ttt act ctg gca tcg aag ctg ttg 211 Val He Ala His Tyr Ser Ser Ser Phe Thr Leu Ala Ser Lys Leu Leu 25 30 35 tcg ccg aaa att cgt cgc gat att gg gca ttg tac gca atg gtg cga 259 Ser Pro Lys He Arg Arg Asp He Glu Ala Leu Tyr Ala Met Val Arg 40 45 50 gtg gcc gat gag gtt gtg gac ggc gct gct gct gcg ggg tgt gcg gct gg 307 • Val Wing Asp Glu Val Val Asp Gly Wing Wing Wing Wing Wing Gly Cys Wing 55 60 65 ccg gac gcc gtt gcg gag att ttg gac aat tac gaa cgc cag gtt ctg 355 Pro Asp Ala Val Wing Glu He Leu Asp Asn Tyr Glu Arg Gln Val Leu 70 75 80 85 etc agt ttg tcc gtt ect ttt cat acc gat gat gtg ate cat gcg ttt 403 Leu Ser Leu Ser Val Pro Phe His Thr Asp Pro Val He His Wing Phe 90 95 100 ggc aat acc gcc cgc aaa tgt ggt ttt gag cag gct falls ate gtg gcg 451 Gly Asn Thr Wing Arg Lys Cys Gly Phe Glu Gln Wing His He Val W 105 105 115 ttt ttt gat tcc atg cgc cgc gat etc tcc ca acc tcc tat gat ccg 499 10 Phe Phe Asp Ser Met Arg Arg Asp Leu Ser Gln Thr Ser Tyr Asp Pro 120 125 130 act cag ttg gat gag tac att tac ggc tcc gct gag gtc ate ggg ttg 547 Thr Gln Leu Asp Glu Tyr He Tyr Gly Ser Wing Glu Val He Gly Leu 135 140 145 atg tgt ttg aaa att ttc etc cata gat tcc act gcc age ccg cag gat 595 Met Cys Leu Lys He Phe Leu Gln Asp Ser Thr Ala Ser Pro Gln Asp 150 155 160 165 cgg gcc acg atg gaa falls ggc gcc agg cgt tg ggt gcg gca ttt caa 643 Arg Wing Thr Met Glu His Gly Wing Arg Arg Leu Gly Wing Wing Phe Gln 170 175 180 aag gta aat ttc ctg cga gat cta gct gaa gac cgc gaa 15 ggc cta ggc 691 Lys Val Asn Phe Leu Arg Asp Leu Wing Glu Asp Arg Glu Gly Leu Gly 185 190 195 cgt tet tat ttg ccg gta ttc acc gaa gag atg cgc gat gag ate gtt 739 Arg Ser Tyr Leu Pro Val Phe Thr Glu Glu Met Arg Asp Glu He Val 200 205 210 act gat ate cga gag gat ttg gat gcc ggg cgg ctg age att ccg ctg 787 Thr Asp He Arg Glu Asp Leu Asp Ala Ala Arg Leu Ser He Pro Leu 215 220 225 • ctg cca ttt gg c gcg acc ggc cgc cgc gcg gcg acc gat etc 835 Leu Pro Phe Gly Wing Arg Thr Gly Val Arg Ala Wing Thr Asp Leu Tyr 230 235 240 245 20 ggt tgc etc gtg gac aac ctg gaa tcc gcg tcc etc gaa gac tta aaa 883 Gly Cys Leu Val Asp Asn Leu Glu Be Wing Ser Leu Glu Asp Leu Lys 250 255 260 aac ggg cgg gat ttt gtg ccg tet tta aaa aag cca gcc tgg caca cca 931 Asn Gly Arg Asp Phe Val Pro Ser Leu Lys Lys Pro Wing Trp Gln Pro 265 270 275 aag cag tgt gga aag aag tgt ttc aaa aat gac aaa age agt ggt cat 979 Lys Gln Cys Gly Lys Lys Cys Phe Lys Asn Asp Lys Ser Ser Gly His 280 285 290 cgg cgg ggg act age agg act age falls falls cgc act gct ctt acg cga 1027 Arg Arg Gly Thr Ser Arg Thr Ser His His Arg Thr Wing Leu Thr Arg 295 300 305 agg ata tgaaigtccac ctcgtcgaac aaa 1056 25 r. , i # & uMae * l Arg He 310 < 210 > 268 < 211 > 311 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 268 Val Wing Asp Gln Gln Asp Phe Leu Gly Arg Phe Asp Wing Met Being 1 5 10 15 Lys Wing Thr Wing Thr Val He Wing His Tyr Being Ser Being Phe Thr Leu 20 25 30 Wing Being Lys Leu Leu Being Pro Lys He Arg Arg Asp He Glu Wing Leu 35 40 45 Tyr Ala Met Val Arg Val Ala Asp Glu Val Val Asp Gly Ala Ala Ala 50 55 60 Ala Ala Gly Cys Ala Pro Asp Ala Val Ala Glu He Leu Asp Asn Tyr 65 70 75 80 Glu Arg Gln Val Leu Leu Ser Leu Ser Val Pro Phe His Thr Asp Pro 85 90 95 Val He His Wing Phe Gly Asn Thr Wing Arg Lys Cys Gly Phe Glu Gln 100 105 110 Wing His He He Val Wing Phe Phe Asp Ser Met Arg Arg Asp Leu Ser Gln 115 120 125 Thr Ser Tyr Asp Pro Thr Gln Leu Asp Glu Tyr He Tyr Gly Ser Ala 130 135 140 Glu Val He Gly Leu Met Cys Leu Lys He Phe Leu Gln Asp Ser Thr 145 150 155 160 Wing Pro Pro Gln Asp Arg Wing Thr Met Glu His Gly Wing Arg Arg Leu 165 170 175 Gly Wing Wing Phe Gln Lys Val Asn Phe Leu Arg Asp Leu Wing Glu Asp 180 185 190 Arg Glu Gly Leu Gly Arg Ser Tyr Leu Pro Val Phe Thr Glu Glu Met 195 200 205 Arg Asp Glu He Val Thr Asp He Arg Glu Asp Leu Asp Ala Ala Arg 210 215 220 Leu Ser He Pro Leu Leu Pro Phe Gly Ala Arg Thr Gly Val Arg Ala 225 230 235 240 Wing Thr Asp Leu Tyr Gly Cys Leu Val Asp Asn Leu Glu Ser Wing Ser 245 250 255 Leu Glu Asp Leu Lys Asn Gly Arg Asp Phe Val Pro Ser Leu Lys 260 265 270 Pro Wing Trp Gln Pro Lys Gln Cys Gly Lys Lys Cys Phe Lys Asn Asp 275 280 285 Lys Ser Ser Gly His Arg Arg Gly Thr Ser Arg Thr Ser His His Arg 290 295 300 Thr Ala Leu Thr Arg Arg He 305 310 < 210 > 269 < 211 > 1239 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1216) < 223 > RXA00480 < 400 > 269 tttatggacc caaatteaca ctttctgtac ttcatcaaaa taaagegeca tatacaaega 60 ttgggaattt ttgcgagata actggccgtg tgatactega atg gac aat ggc atg 115 Met Asp Asn Gly Met 1 5 here tc ct gat ac cat cat cat cat cat cat cat cat cat catcat • Thr He Thr Thr Glu His Ser Thr His Pro Asp Leu Asp Phe Asn Asp 10 15 20 gag att tat cgg gaa cta aac cgc ate tgc gct tcg cta tet caa cag 211 Glu He Tyr Arg Glu Leu Asn Arg He Cys Ala Ser Leu Ser Gln Gln 25 30 35 tgc age here tat caca cca gag ttc cgt acc tgc cta gat gct gct ttc 259 Cys Ser Thr Tyr Gln Pro Glu Phe Arg Thr Cys Leu Asp Ala Wing Phe 40 45 50 ca gct tcg cg ggt ggc aag tta ate cgc ect cga atg cta cg ggg 307 Gln Ala Leu Arg Gly Gly Lys Leu He Arg Pro Arg Met Leu Leu Gly 55 60 65 10 cta tac aac acg ctt gta gac gat gac att gag gtc aaa etc aac acc 355 Leu Tyr Asn Thr Leu Val Asp Asp Asp He Glu Val Lys Leu Asn Thr 70 75 80 85 gtt tta cag gta gca gtg gct tta gaa cta ctg cat ttt tcc ctt ttg 403 Val Leu Gln Val Ala Val Ala Leu Glu Leu Leu His Phe Ser Leu Leu 90 95 100 gtt cat gac gat gtt att gac gga gac etc tat cgc cga ggc aaa ctt 451 Val His Asp Asp Val He Asp Gly Asp Leu Tyr Arg Arg Gly Lys Leu 105 110 115 aat ttt att ggg cag att etc atg cat cgc here ect gaa agt ttt gca 499 Asn Phe He Gly Gln He Leu Met His Arg Thr Pro Glu Ser Phe Wing 120 125 130 15 ca ate cgc gat cca gac cat cta gat tgg gca ca t t aat gga 547 Gln He Gln Arg Asp Pro Glu His Leu Asp Trp Wing Gln Ser Asn Gly 135 140 145 ctg ctt atg gga aat ctt ttt ctt gct gcc acc cat ca ate tc gcg 595 Leu Leu Met Gly Asn Leu Phe Leu Wing Wing Thr His Gln He Phe Wing 150 155 160 165 cgc ctt gac ctt cca cca cat falls cag cgg gtt cga ctt tta gat tta etc 643 Arg Leu Asp Leu Pro His His Gln Arg Val Arg Leu Leu Asp Leu Leu 170 175 180 aac falls acg ata aat gac act att gtg ggt gag ttt ctt gat gtg gga 691 Asn His Thr He Asn Asp Thr He Val Gly Glu Phe Leu Asp Val Gly 185 190 195 20 tta age age aaa gcc ate age ccc aat atg gac att gct cta gaa atg 739 Leu Ser Ser Lys Ala He Ser Pro Asn Met Asp He Wing Leu Glu Met 200 205 210 agt cgg cta aaa here gcc here tact act ttt gaa ctt cca atg aga gca 787 Ser Arg Leu Lys Thr Wing Thr Tyr Thr Phe Glu Leu Pro Met Arg Wing 215 220 225 gcg gca att etc gcg gaa cta ect cag gag att gaa here aag ata ggt 835 Wing Wing He Leu Wing Glu Leu Pro Gln Glu He Glu Thr Lys He Gly 230 235 240 245 gag ata ggc here aac ttg ggc ate gct tat cata ttg cag gac gat tac 883 Glu He Gly Thr Asn Leu Gly He Ala Tyr Gln Leu Gln Asp Asp Tyr 250 255 260 2 tta tet act ttt ggt gac gca gcc gaa cae ggc aaa gat gcc ttt tet 931 t .. A. lili Leu Ser Thr Phe Gly Asp Wing Wing Glu His Gly Lys Asp Wing Phe Ser 265 270 275 gac ctt gaga gga aaa gaa act here att ate gcc ttc gct cga gat 979 Asp Leu Arg Glu Gly Lys Glu Thr Thr He He Wing Wing Phe Wing Arg Asp 280 285 290 act gct aaa tgg act gat att cac gac aac ttc ggc tcc gca gat ctg 1027 Thr Wing Lys Trp Thr Asp He Gln Asp Asn Phe Gly Ser Wing Asp Leu 295 300 305 age acc tet cag gca gag cga att ca cat ctt etc ata cag tgt gga 1075 • Ser Thr Ser Gln Wing Glu Arg He Gln His Leu Leu He Gln Cys Gly 310 315 320 325 gca aag aat falls tcc ttg aat gcc ate tcc gac falls tta aat ate tgc 1123 Wing Lys Asn His Ser Leu Asn Wing He Ser Asp His Leu Asn He Cys 330 335 340 cgt tcg atg ate aaa here cta age ccc cag gta gat ccc aag gct caa 1171 Arg Ser Met He Lys Thr Leu Ser Pro Gln Val Asp Pro Lys Ala Gln 345 350 355 aat tta tta ctt aaa caa gtt gag cata cta gcc age cgc aaa tet 1216 Asn Leu Leu Leu Lys Gln Val Glu Gln Leu Wing Ser Arg Lys Ser 360 365 370 tagaactaac ctttacgcct tta 1239 10 < 210 > 270 < 211 > 372 • < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 270 Met Asp Asn Gly Met Thr He Thr Thr Glu His Ser Thr His Pro Asp 1 5 10 15 Leu Asp Phe Asn Asp Glu He Tyr Arg Glu Leu Asn Arg He Cys Wing 20 25 30 Ser Leu Ser Gln Gln Cys Ser 15 Thr Tyr Gln Pro Glu Phe Arg Thr Cys 35 40 45 Leu Asp Ala Ala Phe Gln Ala Leu Arg Gly Gly Lys Leu He Arg Pro 50 55 60 Arg Met Leu Leu Gly Leu Tyr Asn Thr Leu Val Asp Asp Asp He Glu 65 70 75 80 Val Lys Leu Asn Thr Val Leu Gln Val Wing Val Wing Leu Glu Leu Leu 85 90 95 His Phe Ser Leu Leu Val His Asp Asp Val He Asp Gly Asp Leu Tyr • 100 105 110 Arg Arg Gly Lys Leu Asn Phe He Gly Gln He Leu Met His Arg Thr 115 120 125 20 Pro Glu Ser Phe Wing Gln He Gln Arg Asp Pro Glu His Leu Asp Trp 130 135 140 Wing Gln Ser Asn Gly Leu Leu Met Gly Asn Leu Phe Leu Wing Ala Thr 145 150 155 160 His Gln He Phe Ala Arg Leu Asp Leu Pro His His Gln Arg Val Arg 165 170 175 Leu Leu Asp Leu Leu Asn His Thr He Asn Asp Thr He Val Gly Glu 180 185 190 Phe Leu Asp Val Gly Leu Ser Ser Lys Ala He Ser Pro Asn Met Asp 195 20 0 205 He Wing Leu Glu Met Being Arg Leu Lys Thr Wing Thr Tyr Thr Phe Glu 210 215 220 25 Leu Pro Met Arg Wing Wing Wing He Leu Wing Glu Leu Pro Gln Glu He 1 'MftP' i 'd ^ - 225 230 235 240 Glu Thr Lys He Gly Glu He Gly Thr Asn Leu Gly He Wing Tyr Gln 245 250 255 Leu Gln Asp Asp Tyr Leu Ser Thr Phe Gly Asp Ala Wing Glu His Gly 260 265 270 Lys Asp Wing Phe Ser Asp Leu Arg Glu Gly Lys Glu Thr Thr He He 275 280 285 Wing Phe Wing Arg Asp Thr Wing Lys Trp Thr Asp He Gln Asp Asn Phe 290 295 300 • Gly Ser Wing Asp Leu Ser Thr Ser Gln Wing Glu Arg He Gln His Leu 305 310 315 320 Leu He Gln Cys Gly Wing Lys Asn His Ser Leu Asn Wing He As As 325 330 335 His Leu Asn He Cys Arg Ser Met He Lys Thr Leu Ser Pro Gln Val 340 345 350 Asp Pro Lys Ala Gln Asn Leu Leu Leu Lys Gln Val Glu Gln Leu Ala 355 360 365 Ser Arg Lys Ser 370 10 < 210 > 271 < 211 > 1056 < 212 > DNA < 213 > Corynebacterium glutamicum • < 220 > < 221 > CDS < 222 > (101) .. (1033) < 223 > RXS01879 < 400 > 271 ctttgcgggc < cgctgatatt gatccaacgc ttt; gtggcga aaagcttgat < gtcactgact 60 atgtgcgcct < agctggggtg t1: gcagcaaa aggatg; agaa 15 gtg aaa att acc gct 115 Val Lys He Thr Ala 1 5 aag gcg tgg gcg aaa acc aac ctg cat tta ggt gtg gga ccg gct falls 163 Lys Ala Trp Ala Lys Thr Asn Leu His Leu Gly Val Gly Pro Wing His 10 15 20 gac gat gga ttt drops gag etc atg acg gtg ttt caa acc att gat ctg 211 Asp Asp Gly Phe His Glu Leu Met Thr Val Phe Gln Thr He Asp Leu 25 30 35 ttt gac acc gtc acc tta acc acc etc gat gag gag ttg gtg gag gag 259 Phe Asp Thr Val Thr Leu Thr Thr Leu Asp Glu Glu Leu Val Glu Glu 40 45 50 20 ggg age gtc gtc aag cata tta tet gtg acc ggt gcc ggc ggc gtg ect 307 Gly Ser Val Val Lys Gln Leu Ser Val Thr Gly Wing Arg Gly Val Pro 55 60 65 gag gac gcc age aat ctt gcg tgg cgc gct gtg gat gcg ttg gtt aag 355 Glu Asp Wing Ser Asn Leu Wing Trp Arg Wing Val Asp Wing Leu Val Lys 70 75 80 85 cgg cgc gcg gaa aag acg ccg ctg tet gca gtt tcg ctg cat att tcc 403 Arg Arg Wing Glu Lys Thr Pro Leu Ser Wing Val Ser Leu His He Ser 90 95 100 aag ggg att ccg gtg gct ggc ggc atg gct ggc ggc tet gcg gat gcg 451 Lys Gly He Pro Val Wing Gly Gly Met Wing Gly Gly Ser Wing Asp Wing 105 110 115 25 gcg gcg here ctc cgc gca gtg gat gcc tgg att ggg ect ttc ggc gag 499 ^ .JßS ^ tt Wing Wing Thr Leu Arg Wing Val Asp Wing Trp He Gly Pro Phe Gly Glu 120 125 130 gac here ttg ctg gag gtt gcp gcg gag etc ggc tea gat gtg ccg ttt 547 Asp Thr Leu Leu Glu Val Wing Ala Glu Leu Gly Ser Asp Val Pro Phe 135 140 145 tgc ctg ctt ggt ggc acc atg cgc ggt acc ggt cgc ggc gag cag ctg 595 Cys Leu Leu Gly Gly Thr Met Arg Gly Thr Gly Arg Gly Glu Gln Leu 150 155 160 165 gta gat atg ttg acg cgc ggc aag cta cat tgg gtg gtg gcc gcg atg 643 Val Asp Met Leu Thr Arg Gly Lys Leu His Trp Val Val Wing Wing Met 170 175 180 gcg cat ggc ctg tcc acg ect gag gta ttc aaa aag cat gat gag ctg 691 Wing His Gly Leu Ser Thr Pro Glu Val Phe Lys Lys His Asp Glu Leu 185 190 195 aat ccg ggaaaa tcg cat atg gat ate age gac etc age gcc gca ctt etc 739 Asn Pro GGlluu Ser His Met Asp He Ser Asp Leu Ser Ala Ala Leu Leu 200 205 210 acc ggc aac acc gcc gag ggg ggg cag tgg ctg falls aat gat ctg acc 787 Thr Gly Asn Thr Wing Glu Val Gly Gln Trp Leu His Asn Asp Leu Thr 215 220 225 age gcc gca etc agt ttg cgc ect gaa ctg cgc age gtc etc caa gaa 835 10 Be Ala Ala Leu Ser Leu Arg Pro Glu Leu Arg Ser Val Leu Gln Glu 230 235 240 245 ggc ate cgc tcc ggc gcg cat gca gga att gtc tcc ggc tcc ggc ccg Gly He Arg Ser Gly Ala His Wing Gly He Val Ser Gly Ser Gly Pro 250 255 260 acc acg gta ttc ttg tgc gaa tcg gag falls aaa gcg caa gac gtt aaa 931 Thr Thr Val Phe Leu Cys Glu Ser Glu His Lys Wing Gln Asp Val Lys 265 270 275 gag gcg cta ate gac gcc ggc cag gtg tac gct gct tac acc gcc acc 979 Glu Ala Leu He Asp Ala Gly Gln Val Tyr Ala Ala Tyr Thr Ala Thr 280 285 290 ect gcg gcc tea acc gcc gac cag cgc ggc gca cae att ttg act 1027 15 ggc Gly Pro Ala Ala Ser Thr Ala Asp Gln Arg Gly Ala His He Leu Thr 295 300 305 gtt tea taataaagac aaacttaagt ate 1056 Val Ser 310 < 210 > 272 < 211 > 311 < 212 > PRT < 213 > Corynebacterium glutamicum 20 < 400 > 272 Val Lys He Thr Ala Lys Ala Trp Ala Lys Thr Asn Leu His Leu Gly 1 5 10 15 Val Gly Pro Ala His Asp Asp Gly Phe His Glu Leu Met Thr Val Phe 20 25 30 Gln Thr He Asp Leu Phe Asp Thr Val Thr Leu Thr Thu Leu Asp Glu 35 40 45 Glu Leu Val Glu Glu Gly Ser Val Val Lys Gln Leu Ser Val Thr Gly 50 55 60 Wing Arg Gly Val Pro Glu Asp Wing Ser Asn Leu Wing Trp Arg Wing Val 65 70 75 80 Asp Wing Leu Val Lys Arg Arg Wing Glu Lys Thr Pro Leu Ser Wing Val 25 85 90 95 TesA ^ a., ¿, T. , Ser Leu His He Ser Lys Gly He Pro Val Wing Gly Gly Met Wing Gly 100 105 110 Gly Ser Wing Asp Wing Wing Wing Thr Leu Arg Wing Val Asp Wing Trp He 115 120 125 Gly Pro Phe Gly Glu Asp Thr Leu Leu Glu Val Ala Ala Glu Leu Gly 130 135 140 Ser Asp Val Pro Phe Cys Leu Leu Gly Gly Thr Met Arg Gly Thr Gly 145 150 155 160 Arg Gly Glu Gln Leu Val Asp Met Leu Thr Arg Gly Lys Leu His Trp 165 170 175 Val Val Ala Ala Met Ala His Gly Leu Ser Thr Pro Glu Val Phe Lys 180 185 190 Lys His Asp Glu Leu Asn Pro Glu Ser His Met Asp He Be Asp Leu 195 200 205 Be Ala Ala Leu Leu Thr Gly Asn Thr Ala Glu Val Gly Gln Trp Leu 210 215 220 His Asn Asp Leu Thr Ser Ala Ala Leu Ser Leu Arg Pro Glu Leu Arg 225 230 235 240 Ser Val Leu Gln Glu Gly He Arg Ser Gly Wing His Wing Gly He Val 245 250 255 Ser Gly Ser Gly Pro Thr Thr Val Phe Leu Cys Glu Ser Glu His Lys 260 265 270 Wing Gln Asp Val Lys Glu Wing Leu He Asp Wing Gly Gln Val Tyr Wing 275 280 285 Wing Tyr Thr Wing Thr Gly Pro Wing Wing Ser Thr Wing Asp Gln Arg Gly 290 295 300 Wing His He Leu Thr Val Ser 305 310 < 210 > 273 < 211 > 891 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (868) < 223 > RXS02023 < 400 > 273 gatgtggt; ag < caattttgaa gcagt; aectg agcgagtaac cgcattcggg < gttatcgt gacttccgaa; atgt; aactag agact; agagg aggaaacacg atg gct ect aaa caa 115 Met Ala Pro Lys Gln 1 5 act ccc age cca gag aag aat cga aac ctg gtg gga cca gtt ctg caa 163 Thr Pro Ser Pro Glu Lys Asn Arg Asn Leu Val Gly Pro Val Leu Gln 10 15 20 cgt cgg cag here gag ggt act ttt gat ca a cgc ttg cta gaa atg cgc 211 Arg Arg Gln Thr Glu Gly Thr Phe Asp Gln Arg Leu Leu Glu Met Arg 25 30 35 gct gat falls aat tgg aag falls gcc gat cca tgg cgt gta ctg cgt att 259 Wing Asp His Asn Trp Lys His Wing Asp Pro Trp Arg Val Leu Arg He 40 45 50 cag tet gag ttt gtg gcg ggt ttt gat gcc etc cae gag atg cca aag 307 Gln Ser Glu Phe Val Wing Ala Gly Phe Asp Wing Leu His Glu Met Pro Lys 55 60 65 gcc gta gta acc gtc ttt ggt tcc gca cgc att aaa gag gat falls ccg tac 355 Wing Val Thr Val Phe Gly Ser Wing Arg He Lys Glu Asp His Pro Tyr 70 75 80 85 tac aag gcg ggt gta gaa ctt ggt gaa aag etc gtt gca gcg gac tac 403 Tyr Lys Wing Gly Val Glu Leu Gly Glu Lys Leu Val Wing Wing Asp Tyr 90 95 100 gca gtt gtc ggc ggt ggt cca ggt ctg atg gaa gcc ccc aat aag 451 Wing Val Val Thr Gly Gly Pro Gly Leu Met Glu Pro Wing Asn Lys 105 110 115 ggg gca age gag gcc aat ggt tta tea gtt ggt ctg ggc att gag ttg 499 Gly Wing Ser Glu Wing Asn Gly Leu Ser Val Gly Leu Gly He Glu Leu 120 125 130 cca cat gaa cag cat ctg aac ect tat gtg gat ttg ggt ctg aac ttc 547 Pro His Glu Gln His Leu Asn Pro Tyr Val Asp Leu Gly Leu Asn Phe 135 140 145 cgg tac ttc tcc gca cgc aag acc atc ttc ctg aaa tac tcc cag gct 595 Arg Tyr Phe Phe Wing Arg Lys Thr Met Phe Leu Lys Tyr Ser Gln Wing 150 155 160 165 ttt gtg tgt ctg ect ggt ggt ttc ggc acg etc gat gag ctt ttc gag 643 Phe Val Cys Leu Pro Gly Gly Phe Gly Thr Leu Asp Glu Leu Phe Glu 170 175 180 gtc etc tgc atg gta cata acc ggc aag gta ccc aac ttt ccc ate gtg 691 Val Leu Cys Met Val Gln Thr Gly Lys Val Pro Asn Phe Pro He Val 185 190 195 ctg ate ggc act gag ttc tgg gca ggt ttg gtg gat tgg ate cgt cae 739 Leu He Gly Thr Glu Phe Trp Wing Gly Leu Val Asp Trp He Arg His 200 205 210 cgc ctg gta gag gag ggc atg ate gat gag aag gat gtt gac cgg atg 787 Arg Leu Val Glu Glu Gly Met He Asp Glu Lys Asp Val Asp Arg Met 215 220 225 ttg gtc act gat gac ctg gat cag gcc gtc aaa ttc ate gtc gat gca 835 Leu Val Thr Asp Asp Leu Asp Gln Wing Val Lys Phe He Val Asp Wing 230 235 240 245 falls gct gga ttg gac gta gcg cgt etc falls aat taageagtgg ctacattagg His Wing Gly Leu Asp Val Wing Arg Leu His Asn 250 255 tgt 891 < 210 > 274 < 211 > 256 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 274 Met Wing Pro Lys Gln Thr Pro Pro Pro Glu Lys Asn Arg Asn Leu Val 1 5 10 15 Gly Pro Val Leu Gln Arg Arg Gln Thr Glu Gly Thr Phe Asp Gln Arg 20 25 30 Leu Leu Glu Met Arg Ala Asp His Asn Trp Lys His Wing Asp Pro Trp 35 40 45 Arg Val Leu Arg He Gln Ser Glu Phe Val Wing Gly Phe Asp Wing Leu 50 55 60 His Glu Met Pro Lys Wing Val Thr Val Phe Gly Ser Wing Arg He Lys 65 70 75 Glu Asp His Pro Tyr Tyr Lys Wing Gly Val Glu Leu Gly Glu Lys Leu 85 90 95 Val Wing Wing Asp Tyr Wing Val Val Thr Gly Gly Pro Gly Leu Met 100 105 110 Glu Wing Pro Asn Lys Gly Wing Ser Glu Wing Asn Gly Leu Ser Val Gly 115 120 125 Leu Gly He Glu Leu Pro His Glu Gln His Leu Asn Pro Tyr Val Asp 130 135 140 Leu Gly Leu Asn Phe Arg Tyr Phe Phe Wing Arg Lys Thr Met Phe Leu 145 150 155 160 Lys Tyr Ser Gln Wing Phe Val Cys Leu Pro Gly Gly Phe Gly Thr Leu 165 170 175 Asp Glu Leu Phe Glu Val Leu Cys Met Val Gln Thr Gly Lys Val Pro • 180 185 190 Asn Phe Pro He Val Leu He Gly Thr Glu Phe Trp Wing Gly Leu Val 195 200 205 Asp Trp He Arg His Arg Leu Val Glu Glu Gly Met He Asp Glu Lys 210 215 220 Asp Val Asp Arg Met Leu Val Thr Asp Asp Leu Asp Gln Wing Val Lys 225 230 235 240 Phe He Val Asp Ala His Wing Gly Leu Asp Val Wing Arg Leu His Asn 245 250 255 < 210 > 275 < 211 > 1242 10 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1219) < 223 > RXS00948 < 400 > 275 acaccctcca aatgatctcg taaaacagta ttgaatttag gtaegactet aatcgtacct 60 tgccctcaag ecaagetagt tgtacgatca aactcgttgt atg gca aac gtc gta 115 15 Met Ala Asn Val Val 1 5 cta gtc gat cga atg gag ect ttg gtg tcc aag ctg ttt acc cca att 163 Leu Val Asp Arg Met Glu Pro Leu Val Ser Lys Leu Phe Thr Pro He 10 15 20 ca ate ate cgc gac ate acc ate ccc a gc t g tg tg atg ate ccg atg 211 Gln He Arg Asp He Thr He Pro Asn Arg Val Trp Met Ser Pro Met 25 30 35 tgc acc tac tet gca gcc ggt tea ggt ctt cct acc gat ttt drops 259 Cys Thr Tyr Ser Wing Wing Thr Gly Ser Gly Leu Pro Thr Asp Phe His 40 45 50 cag gct cat tac gca gc cgc gca gca ggt ggt gtc gga tta gtc atg 307 20 Gln Ala His Tyr Ala Ala Arg Ala Ala Gly Gly Val Gly Leu Val Met 55 60 65 gtt gaa gca act gga gtg aac ccc gta gcc ccc ate tcc cca gtc gac 355 Val Glu Ala Thr Gly Val Asn Pro Val Ala Pro He Ser Pro Val Asp 70 75 80 85 ctt gga ctt tgg age cat gac caa att gaa cca ttc tcc cga gtg here 403 Leu Gly Leu Trp Ser His Asp Gln He Glu Pro Phe Ser Arg Val Thr 90 95 100 gca gct att cgc gcc ggt ggg gca gta gc gcc gtt cata tta gcc cat 451 Ala Ala He Arg Ala Gly Gly Ala Val Pro Ala Val Gln Leu Ala His 105 110 115 gct ggc cgc aag gca tcc acc gat gct ccg tgg aat ggt ggc gga tat 499 25 Wing Gly Arg Lys Wing Being Thr Asp Wing Pro Trp Asn Gly Gly Gly Tyr . .. 4 n < faBBa ^ 120 125 130 gtt gga cca gaa acc aat gga tgg gag act gtc gcc ccc age ect ctg 547 Val Gly Pro Glu Thr Asn Gly Trp Glu Thr Val Gly Pro Ser Pro Leu 135 140 145 gca ttc cca ggt ttg ect gct ccg cgc gag ctg acg gtt tea gaa ate 595 Wing Phe Pro Gly Leu Pro Wing Pro Arg Glu Leu Thr Val Ser Glu He 150 155 160 165 caá gag gtt gtg cag cag ttc gct ggc gcc gcc gtt cgt gcc gat cag 643 • Gln Glu Val Val Gln Gln Phe Wing Gly Wing Wing Val Arg Wing Asp Gln 170 175 180 gct gtt ttt gat gtc gtg gaa att falls gca gca falls ggc tac ctt ttg 691 Wing Gly Phe Asp Val Val Glu He His Wing Wing His Gly Tyr Leu Leu 185 190 195 cat aac ttc ctt tet ccg ate tcc aac aag cgc acc acte tea tac ggc 739 His Asn Phe Leu Ser Pro He Ser Asn Lys Arg Thr Asp Ser Tyr Gly 200 205 210 gga tet tta gaa aac cgc gct cgc ate gtg etc gaa gtc att gat gca 787 Gly Ser Leu Glu Asn Arg Ala Arg He Val Leu Glu Val He Asp Ala 215 220 225 ate cgc gca gtg tgg cca gag gaa aag ect gta ttc atg cgc att tcc 835 He Arg Ala Val Trp Pro Glu Glu Lys Pro Val Phe Met Arg He Ser 10 230 235 240 245 acc acc gac tgg gtg gag gaa aac cca cag gat gat cgc gag tcc tgg Thr Thr Asp Trp Val Glu Glu Asn Pro Gln Asp Asp Arg Glu Ser Trp 250 255 260 acg ctg age cag age agg cag ctg gct ttg tgg gca tcc gag falls gga 931 Thr Leu Ser Gln Ser Arg Gln Leu Ala Leu Trp Wing Ser Glu His Gly 265 270 275 gtt gat ttg ate gat gcc tet tet ggt ggc etc gac ate gtc ccc att 979 Val Asp Leu He Asp Wing Ser Ser Gly Gly Leu Asp He Val Pro He 280 285 290 ccg cat gac cgc gat tac caa acc gcg aag gcc gca gat ctt cae gca 1027 Pro His Asp Arg Asp Tyr Gln Thr Wing Lys Wing Wing Asp Leu His Wing 15 295 300 305 agt acc gga gtg here gtc gct gct gtg ggg cgc att gat gac gcc caa 1075 Ser Thr Gly Val Thr Val Wing Wing Val Gly Arg He Asp Asp Wing Gln 310 315 320 325 act gcg falls aat ttg gtt gat tet ggc gat gtc aat gca gtc ttc etc 1123 Thr Ala His Asn Leu Val Asp Ser Gly Asp Val Asn Ala Val Phe Leu 330 335 340 ggc cgt cca ctg etc aag gat ect tcc tgg gca aac ca gca gc gcc etc 1171 Gly Arg Pro Leu Leu Lys Asp Pro Ser Trp Wing Asn Gln Wing Wing Leu 345 350 355 gca cta ggt gcg gaa ccc agg tat gtt falls cac tac gac tac gta ctt 1219 Wing Leu Gly Wing Glu Pro Arg Tyr Val His Gln Tyr Asp Tyr Val Leu 20 360 365 370 taaaggagag ttgacatgaa ggt 1242 < 210 > 276 < 211 > 373 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 276 Met Wing Asn Val Val Leu Val Asp Arg Met Glu Pro Leu Val Ser Lys 1 5 10 15 25 Leu Phe Thr Pro He Gln He Arg Asp He Thr He Pro Asn Arg Val 20 25 30 Trp Met Ser Pro Met Cys Thr Tyr Ser Ala Ala Thr Gly Ser Gly Leu 35 40 45 Pro Thr Asp Phe His Gln Ala His Tyr Ala Ala Arg Ala Ala Gly Gly 50 55 60 Val Gly Leu Val Met Val Glu Ala Thr Gly Val Asn Pro Val Ala Pro 65 70 75 80 He Ser Pro Val Asp Leu Gly Leu Trp Ser His Asp Gln He Glu Pro • 85 90 95 Phe Ser Arg Val Thr Ala Ala He Arg Ala Gly Gly Ala Val Pro Ala 100 105 110 Val Gln Leu Ala His Wing Gly Arg Lys Ala Ser Thr Asp Wing Pro Trp 115 120 125 Asn Gly Gly Gly Tyr Val Gly Pro Glu Thr Asn Gly Trp Glu Thr Val 130 135 140 Gly Pro Pro Pro Leu Wing Phe Pro Gly Leu Pro Wing Pro Arg Glu Leu 145 150 155 160 Thr Val Ser Glu He Gln Glu Val Val Gln Gln Phe Wing Gly Ala Wing 165 170 175 Val Arg Wing Asp Gln Wing Gly Phe Asp Val Val Glu He His Wing Wing 180 185 190 10 His Gly Tyr Leu Leu His Asn Phe Leu Ser Pro He Ser Asn Lys Arg 195 200 205 Thr Asp Ser Tyr Gly Gly Ser Leu Glu Asn Arg Wing Arg He Val Leu • 210 215 220 Glu Val He Asp Wing He Arg Wing Val Trp Pro Glu Glu Lys Pro Val 225 230 235 240 Phe Met Arg He Ser Thr Thr Asp Trp Val Glu Glu Asn Pro Gln Asp 245 250 255 Asp Arg Glu Ser Trp Thr Leu Ser Gln Ser Arg Gln Leu Ala Leu Trp 260 265 270 Wing Ser Glu His Gly Val Asp Leu He Asp Wing Ser Ser Gly Gly Leu 275 280 285 15 Asp He Val Pro He Pro His Asp Arg Asp Tyr Gln Thr Ala Lys Wing 290 295 300 Wing Asp Leu His Wing Ser Thr Gly Val Thr Val Wing Wing Val Gly Arg 305 310 315 320 He Asp Asp Wing Gln Thr Wing His Asn Leu Val Asp Ser Gly Asp Val 325 330 335 Asn Wing Val Phe Leu Gly Arg Pro Leu Leu Lys Asp Pro Ser Trp Wing • 340 345 350 Asn Gln Ala Ala Leu Ala Leu Gly Ala Glu Pro Arg Tyr Val His Gln 355 360 365 Tyr Asp Tyr Val Leu 370 20 < 210 > 277 < 211 > 1026 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1003) < 223 > RXS02228 < 400 > 277 25 ff ^ KffiiKftaflMféf acatgaagícgt, caactgctica acttctcgac agcgacgaca cacaegg.cgt iggga, egetac 60 gttgctctgct iggactttt "ta acttaaggga ga-teta, gatc gtg gta here ccg ate 115 Val Val Thr Pro He 1 5 gca gtg gtt gga ccc act gca tet gga aaa tea gct ttg gga att gct 163 Wing Val Val Gly Pro Thr Wing Ser Gly Lys Ser Wing Leu Gly Wing 10 15 20 cta gcc falls aag ctt gac ggt gaa gta gtc aat gtg gat tcc atg cag 211 Leu Ala His Lys Leu Asp Gly Glu Val Val Asn Val Asp Ser Met Gln • 25 30 35 ctg tac aaa ggc atg gac ate ggc acg gca aag ctg act gtc gaa gaa 259 Leu Tyr Lys Gly Met Asp He Gly Thr Ala Lys Leu Thr Val Glu Glu 40 45 50 cgc gaa ggc att gcg cat cat cag etc gat gtc tgg gac gtt acc gaa 307 Arg Glu Gly He Wing His His Gln Leu Asp Val Trp Asp Val Thr Glu 55 60 65 act gcg tea gtg gcg agg ttt cac tcc gac gcc gtt gcc gat gtg gaa 355 Thr Ala Ser Val Wing Arg Phe Gln Ser Asp Wing Val Wing Asp Val Glu 70 75 80 85 gat att atg tcc cgt ggc aaa acc ccc ate ttg gtt ggc ggc tcc atg 403 10 Asp He Met Being Arg Gly Lys Thr Pro He Leu Val Gly Gly Being Met 90 95 100 ttg tac gtc cata tet ttg gtc gat gat tgg cca ect acc gac 451 Leu Tyr Val Gln Ser Leu Val Asp Asp Trp Gln Phe Pro Pro Thr Asp • 105 110 115 age gct cgc gca cgc ttt gag gcc cgc ttg gca gac ate ggt gtc 499 Ser Ala Val Arg Ala Arg Phe Glu Ala Arg Leu Ala Asp He Gly Val 120 125 130 gaa gca cta cae gct gaa ctt act cag ctt gac cca gaa gca gca gcc 547 Glu Ala Leu His Ala Glu Leu Thr Gln Leu Asp Pro Glu Ala Ala Ala 135 140 145 gtc ate gaa age aat gat ccc cga cgc acc gtc cga gca tta gaa gtc 595 15 Val He Glu Be Asn Asp Pro Arg Arg Thr Val Arg Ala Leu Glu Val 150 155 160 165 att gaa cta acc ggc cag ccc ttc caca gca age caac cc cc aaa gac 643 He Glu Leu Thr Gly Gln Pro Phe Gln Ala Ser Gln Pro Pro Lys Asp 170 175 180 gcg cca ect cgc tgg gga act cga ate att ggc ctg aaa acc act cca 691 Wing Pro Pro Arg Trp Gly Thr Arg He He Gly Leu Lys Thr Thr Pro 185 190 195 gaa tgg cta aat cca cgc ate gag cag cgc acc gcc agg atg ttt gaa 739 • Glu Trp Leu Asn Pro Arg He Glu Gln Arg Thr Wing Arg Met Phe Glu 200 205 210 ca ggc ttt gtc gcc gaa gtg gaa falls ctt gtg cag ca gga etc ate 787 20 Gln Gly Phe Val Wing Glu Val Glu His Leu Val Gln Gln Gly Leu He 215 220 225 gct gac tcc acc gcg gga cga gca ate ggc tac tcc ca gta cta g g 835 Wing Asp Ser Thr Wing Gly Arg Wing He Gly Tyr Ser Gln Val Leu Wing 230 235 240 245 gcc atg gca ggg gag atg acc tgg gaa gac gcc ttc gaa cgc acg gtc 883 Wing Met Wing Gly Glu Met Thr Trp Glu Asp Wing Phe Glu Arg Thr Val 250 255 260 acc gga acc aga cgc tat gtc agg cgc ca ccc age tgg ttc aac aga 931 Thr Gly Thr Arg Arg Tyr Val Arg Arg Gln Arg Ser Trp Phe Asn Arg 265 270 275 gac drops cgc gtg tcc tgg gtc gac gcc tet ggc gat ccc acc gca ca 979 25 Asp His Arg Val Ser Trp Val Asp Wing Ser Gly Asp Pro Thr Wing Gln 280 285 290 gcc ttg gag att ttg ggt cta cac tagcgagggt gaatttgacc ate 1026 Wing Leu Glu He Leu Gly Leu Gln 295 300 < 210 > 278 < 211 > 301 < 212 > PRT • < 213 > Corynebacterium glutamicum < 400 > 278 Val Val Thr Pro He Wing Val Val Gly Pro Thr Wing Ser Gly Lys Ser 1 5 10 15 Wing Leu Gly Wing Wing Leu Wing His Lys Leu Asp Gly Val Val Asn 20 25 30 Val Asp Ser Met Gln Leu Tyr Lys Gly Met Asp He Gly Thr Ala Lys 35 40 45 Leu Thr Val Glu Glu Arg Glu Gly He Wing His His Gln Leu Asp Val 50 55 60 Trp Asp Val Thr Glu Thr Wing Ser Val Wing Arg Phe Gln Ser Asp Wing 10 65 70 75 80 Val Wing Asp Val Glu Asp He Met Be Arg Gly Lys Thr Pro He Leu 85 90 95 Val Gly Gly Ser Met Leu Tyr Val Gln Ser Leu Val Asp Asp Trp Gln 100 105 110 Phe Pro Pro Thr Asp Ser Wing Val Arg Ala Arg Phe Glu Wing Arg Leu 115 120 125 Wing Asp He Gly Val Glu Wing Leu His Wing Glu Leu Thr Gln Leu Asp 130 135 140 Pro Glu Wing Wing Wing Val He Glu Ser Asn Asp Pro Arg Arg Thr Val 145 150 155 160 Arg Ala Leu Glu Val He Glu Leu Thr Gly Gln Pro Phe Gln Wing Ser 15 165 170 175 Gln Pro Pro Lys Asp Wing Pro Pro Arg Trp Gly Thr Arg He He Gly 180 185 190 Leu Lys Thr Thr Pro Glu Trp Leu Asn Pro Arg He Glu Gln Arg Thr 195 200 205 Wing Arg Met Phe Glu Gln Gly Phe Val Wing Glu Val Glu His Leu Val 210 215 220 Gln Gln Gly Leu He Wing Asp Ser Thr Wing Gly Arg Wing He Gly Tyr 225 230 235 240 Ser Gln Val Leu Wing Wing Met Wing Gly Glu Met Thr Trp Glu Asp Wing 245 250 255 Phe Glu Arg Thr Val Thr Gly Thr Arg Arg Tyr Val Arg Arg Gln Arg 20 260 265 270 Ser Trp Phe Asn Arg Asp His Arg Val Ser Trp Val Asp Wing Ser Gly 275 280 285 Asp Pro Thr Ala Gln Ala Leu Glu He Leu Gly Leu Gln 290 295 300 <; 210 > 279 < 211 > 954 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > 25 < 221 > CDS < 222 > (101) .. (931) < 223 > RXC01971 < 400 > 279 aggtctt < gtt 'tatttegget aietga'ttcag taigctgieget ccgataggat • tcttagtttt 60 cagttcaigta tctttgagíce acggctagaa tgtgaatcct atg tet aag aag aag 115 Met Ser Lys Lys Lys 1 5 ect cgc ccc att ccg gtt ect gcc caà ttt ate ect ggt etc att gat 163 • Pro Arg Pro He Pro Val Pro Wing Gln Phe He Pro Gly Leu He Asp 10 15 20 gcg cat here cat ttg gca tcg tgt gga gga gat ctt gca ggg ttg gtg 211 Wing His Thr His Leu Wing Ser Cys Gly Gly Asp Leu Wing Gly Leu Val 25 30 35 gaa agg gcc aag gag gcg ggc gtc gaa aag ctt tgt acc gtc ggt gat 259 Glu Arg Wing Lys Glu Wing Gly Val Glu Lys Leu Cys Thr Val Gly Asp 40 45 50 ggt ttg gct gag gcc gag ctt gcg ctg gag gcc gcg ca cag ttt ggc 307 Gly Leu Wing Glu Wing Glu Leu Wing Leu Glu Wing Wing Gln Gln Phe Gly 55 60 65 10 aat gtg ttt gct gcg tgt gcg att cat ccg acg aag gct gat cag ttg 355 Asn Val Phe Ala Wing Cys Ala He His Pro Thr Lys Wing Asp Gln Leu 70 75 80 85 gat ggg gct gcg cgt gcg cgg cg gg gg ggg cg gg gg gg cg gg gg gg gg gg gg cg cg gg gg gg gg gg gg gg gg ggg cg aat 403 Asp Gly Ala Wg Arg Leu Thr Gln Met Wing Wing Asp Pro Asn 90 95 100 tgt gtg gcc att ggt gag act ggt ttg gat tcg tat tgg ate aag drops 451 Cys Val Wing He Gly Glu Thr Gly Leu Asp Ser Tyr Trp He Lys His 105 110 115 gat cea gag gac acg gcg gcg ttg gat gtg cag gag gag gcg ctg cgc 499 Asp Pro Glu Asp Thr Wing Wing Leu Asp Val Gln Glu Glu Wing Leu Arg 120 125 130 15 tgg cat att gat ttg gca att agt gcg gat aag ccg ttg atg att cae 547 Trp His He Asp Leu Wing He Wing Wing Asp Lys Pro Leu Met He His 135 140 145 aat cgt gag gcg gat gct gat ttg atg cga gtg ttg gcg gat gct cca 595 Asn Arg Glu Wing Asp Wing Asp Leu Met Arg Val Leu Wing Asp Ala Pro 150 155 160 165 ect cca aaa gat acg att ctg cat tgt ttt tet tcg ccg ttg gac gtg 643 Pro Pro Lys Asp Thr He Leu His Cys Phe Ser Ser Pro Leu Asp Val 170 175 180 gcg aag gaa gcg ttg gat cgt gga tat gtg ttg agt ttt gcg ggc aat 691 Wing Lys Glu Wing Leu Asp Arg Gly Tyr Val Leu Ser Phe Wing Gly Asn 185 190 195 20 gtg acg ttt aag cgt aat gag gag ttg cgg gag gct gct cgt att gcg 739 Val Thr Phe Lys Arg Asn Glu Glu Leu Arg Glu Wing Wing Arg He Wing 200 205 210 ccg att tcc cag att ttg att gaa acc gat gcg ccg tat atg acg ccg 787 Pro He Ser Gln He Leu He Glu Thr Asp Ala Pro Tyr Met Thr Pro 215 220 225 gag ccg ttt cgg ggg agg aat gag ccg tcg ttg att ggt cat acg 835 Glu Pro Phe Arg Gly Ser Arg Asn Glu Pro Ser Leu He Gly His Thr 230 235 240 245 gcg cta tgc att gcg gag gtt cgg ggg atg gct gtg gag gat gtt gcg 883 Wing Leu Cys He Wing Glu Val Arg Gly Met Wing Val Glu Asp Val Wing 250 255 260 25 gcg gct ttg aat gag aat ttt gat cgc gtt tat ggg gtc here aat cta 931 l »ii? * > TO? tíiiifl ^ FÉN 'Ala Ala Leu Asn Glu Asn Phe Asp Arg Val Tyr Gly Val Thr Asn Leu 265 270 275 taacgtgagg tagctcacag tea 954 < 210 > 280 < 211 > 277 < 212 > PRT < 213 > Corynebacterium glutamicum • < 400 > 280 Met Ser Lys Lys Pro Arg Pro Pro Val Pro Ala Gln Phe He 1 5 10 15 Pro Gly Leu He Asp Ala His Thr His Leu Ala Ser Cys Gly Gly Asp 20 25 30 Leu Ala Gly Leu Val Glu Arg Ala Lys Glu Wing Gly Val Glu Lys Leu 35 40 45 Cys Thr Val Gly Asp Gly Leu Wing Glu Wing Glu Leu Wing Leu Glu Wing 50 55 60 Wing Gln Gln Phe Gly Asn Val Phe Wing Wing Cys Wing He His Pro Thr 65 70 75 80 10 Lys Wing Asp Gln Leu Asp Gly Wing Wing Arg Wing Arg Leu Thr Gln Met 85 90 95 Wing Wing Asp Pro Asn Cys Val Wing He Gly Glu Thr Gly Leu Asp Ser 100 105 110 • Tyr Trp He Lys His Asp Pro Glu Asp Thr Wing Ala Leu Asp Val Gln 115 120 125 Glu Glu Wing Leu Arg Trp His He Asp Leu Wing He Wing Asp Lys 130 135 140 Pro Leu Met He His Asn Arg Glu Wing Asp Wing Asp Leu Met Arg Val 145 150 155 160 Leu Wing Asp Wing Pro Pro Pro Lys Asp Thr He Leu His Cys Phe Ser 165 170 175 15 Ser Pro Leu Asp Val Ala Lys Glu Ala Leu Asp Arg Gly Tyr Val Leu 180 185 190 Ser Phe Wing Gly Asn Val Thr Phe Lys Arg Asn Glu Glu Leu Arg Glu 195 200 205 Wing Wing Arg He Wing Pro He Ser Gln He Leu He Glu Thr Asp Wing 210 215 220 Pro Tyr Met Thr Pro Glu Pro Phe Arg Gly Ser Arg Asn Glu Pro Ser 225 230 235 240 Leu He Gly His Thr Ala Leu Cys He Wing Glu Val Arg Gly Met Wing 245 250 255 Val Glu Asp Val Wing Wing Wing Leu Asn Glu Asn Phe Asp Arg Val Tyr 260 265 270 20 Gly Val Thr Asn Leu 275 <; 210 > 281 < 211 > 1650 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1627) < 223 > RXC02697 25 < 400 > 281 tttggct, cae, eteg, atgatg t, agacatccc cg, atga, ggtg cgcgcacagt tgcgggcact 60 ggctatcicgc -tcaa, cegaac gtcggatgt; a gt; agacgcgt atg here ctt ttt caa 115 Met Thr Leu Phe Gln 1 5 cgt tta acc aac ect gta gtg etc ggc ggc cta gca ggt gtt ttg ctt 163 Arg Leu Thr Asn Pro Val Val Leu Gly Gly Leu Wing Gly Val Leu Leu 10 15 20 ctg etc ggc tet ttc ggt ggc ggt gcc att cgg tac cgt ggc gga gtg 211 • Leu Leu Gly Be Phe Gly Gly Gly Wing He Arg Tyr Arg Gly Gly Val 25 30 35 etc gat gcg ttg ggg ctt aac ttc ctt gct ttt ggc drops gcg cag ggt 259 Leu Asp Wing Leu Gly Leu Asn Phe Leu Wing Phe Gly His Wing Gln Gly 40 45 50 att tcc aat acc gtg ttg tgg gtt ggg cag ctg ctg ctg att ggc gcg 307 He Be As As Thr Val Leu Trp Val Gly Gln Leu Leu He Gly Wing 55 60 65 tgg gtt fall ctt gga cgt cgg ttg ttc aag aaa aaa gtc gct gat gac 355 Trp Val His Leu Gly Arg Arg Leu Phe Lys Lys Lys Val Wing Asp Asp 70 75 80 85 10 acc gca gac gct gct gac tta ggt ctt gta aag cgc acg ttg tat gcc 403 Thr Wing Asp Wing Wing Asp Leu Gly Leu Val Lys Arg Thr Leu Tyr Wing 90 95 100 atg gtg gtg ccc etc att ttt gcg gca cca atg atg tcg cgt gat gtt 451 Met Val Val Pro Leu He Phe Wing Wing Pro Met Met Ser Arg Asp Val 105 110 115 tat tcc tat etc atg cag ggc gcg atg ctg cgt gat ggc ttc gat ccc 499 Tyr Ser Tyr Leu Met Gln Gly Wing Met Leu Arg Asp Gly Phe Asp Pro 120 125 130 tac act gag ggc gct gcg gta aac ect ggc ccc atg ttg ctt gag gtc 547 Tyr Thr Glu Gly Wing Wing Val Asn Pro Gly Pro Met Leu Leu Glu Val 135 140 145 15 tet cat gat tgg cgc aac acc acg acg ccg tat ggt cca cta cae ctg 595 Ser His Asp Trp Arg Asn Thr Thr Thr Pro Tyr Gly Pro Leu His Leu 150 155 160 165 tgg att gga gac atg ate acc acg gtt gtg ggc gat aat gtc acc ttg 643 Trp He Gly Asp Met He Thr Thr Val Val Gly Asp Asn Val Thr Leu 170 175 180 ggc gtc gtc gct tac aag ate ttg tcg ate att ggc ctt gct gtg here 691 Gly Val Val Wing Tyr Lys He Leu Ser He He Gly Leu Wing Val Thr 185 190 195 ggc tgg age att gtc cgc att gca ca cat ttt gga gcc aac cca gca 739 Gly Trp Ser He Val Arg He Wing Gln His Phe Gly Wing Asn Pro Wing 200 205 210 20 att gca ttg tgg att ggt gtg gcc aat ect gtg atg ate ate cae atg 787 I have Ala Leu Trp He Gly Val Ala Asn Pro Val Met He He His Met 215 220 225 ate ggc ggc atg falls aat gaa tcc etc atg gtg gga ttg gtc age gtc 835 He Gly Gly Met His Asn Glu Be Leu Met Val Gly Leu Val Ser Val 230 235 240 245 ggc ttg ttg cta gca ctg aag aag cgt ttc gtg gca ggt gtg gca etc 883 Gly Leu Leu Leu Wing Leu Lys Lys Arg Phe Val Wing Gly Val Wing Leu 250 255 260 att gca gtg gct gtg tcg ctg aaa gct here gcg gcg att gca ctt ect 931 Wing Wing Wing Wing Wing Wing Wing Wing Wing Wing Wing Wing Wing Wing Wing Wing Wing Wing Wing Wing Wing Wing Wing Wing Wing Wing Wing Wing Wing Wing Wing Wing Wing Wing Wing you »«, __i- _ Phe Val Val Trp He Gly Met His His Phe Wing Gly Phe Leu Wing Thr 280 285 290 aaa aag ggc aaa gac tcc ect acc a ct a g cac g gc gcg ttc 1027 Lys Lys Gly Lys Asp Ser Pro Thr Leu Lys Gln Gln Val Pro Wing Phe 295 300 305 ttt gcc act gga gct gca ggt gtt gct gtc act ggt gtt gtt gtc agt 1075 • Phe Ala Thr Gly Ala Ala Gly Val Ala Val Thr Gly Val Val Val Ser 310 315 320 325 gcg ate act tgg gcg tet ggc gct tcg tgg ggc tgg ate agt gag ate 1123 Wing He Thr Trp Wing Ser Gly Wing Ser Trp Gly Trp He Ser Glu He 330 335 340 agt ggc aac age aag gta ate aac ccg ctg gct ttc ect tet ttg gtg 1171 Ser Gly Asn Ser Lys Val He Asn Pro Leu Wing Phe Pro Ser Leu Val 345 350 355 gcc agt gtg ate acc atg gtg gct gaa gtg ttc gtt gac gat ttc gac 1219 Wing Ser Val He Thr Met Val Wing Glu Val Phe Val Asp Asp Phe Asp 360 365 370 tac aac gca gtg gtt aat gtt gtg cgc tea ate tcc atg ctg ate atg 1267 Tyr Asn Wing Val Val Asn Val Val Arg Ser He Met Met Leu He Met 375 380 385 ctt ggc ggg ttg gtc gta tgt tgg tgg ctg ttc cgc cag aac gaa cgc 1315 Leu Gly Gly Leu Val Val Cys Trp Trp Leu Phe Arg Gln Asn Glu Arg 390 395 400 405 agg gcg gtc act ggt here gca gcg gct tat gcc gtg gct ttt gtg ttc 1363 Arg Ala Val Thr Gly Thr Ala Ala Ala Tyr Ala Val Ala Phe Val Phe 410 415 420 aat tet gtg acc ttg ccg tgg tac tac gcc age ttg ate tet ttg etc 1411 Asn Ser Val Thr Leu Pro Trp Tyr Tyr Wing Ser Leu He Ser Leu Leu 425 430 435 ggc here ttt aaa cca ccg atg tgg ttg att cgc ttc gca gcg ggt gct 1459 Gly Thr Phe Lys Pro Pro Met Trp Leu He Arg Phe Ala Wing Gly Wing 440 445 450 tcg gtg ttt ate gcg ctg atg ttt acc gga agt gga aac falls cag ctg 1507 Ser Val Phe He Wing Leu Met Phe Thr Gly Ser Gly Asn His Gln Leu 455 460 465 tac aac ate gtt acg gtg ate ate gca gca att ate gcg tgg ctt gcc 1555 Tyr Asn He Val Thr Val He He Wing Wing He He Wing Trp Leu Wing 470 475 480 485 acc gtg gtg ate ttt gat gac act gac ect gca here acg gcc acg gag 1603 Thr Val Val He Phe Asp Asp Thr Asp Pro Wing Thr Thr Wing Thr Glu 490 495 500 aaa ccc tcc ccg cat acc gtt tcc tagttgcata aggtaaaccg cca 1650 Lys Pro Ser Pro His Thr Val Ser 505 < 210 > 282 < 211 > 509 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 282 Met Thr Leu Phe Gln Arg Leu Thr Asn Pro Val Val Leu Gly Gly Leu 1 5 10 15 Wing Gly Val Leu Leu Leu Leu Gly Ser Phe Gly Gly Gly Wing He Arg 20 25 30 Tyr Arg Gly Gly Val Leu Asp Wing Leu Gly Leu Asn Phe Leu Ala Phe 35 40 45 Í..Í? ? J4? r. * 4, * laugh, • 4-4 to Lr, Gly His Wing Gln Gly He Ser Asn Thr Val Leu Trp Val Gly Gln Leu 50 55 60 Leu Leu He Gly Wing Trp Val His Leu Gly Arg Arg Leu Phe Lys Lys 65 70 75 80 Lys Val Wing Asp Asp Thr Wing Asp Wing Wing Asp Leu Gly Leu Val Lys 85 90 95 Arg Thr Leu Tyr Wing Met Val Val Pro Leu He Phe Wing Wing Pro Met 100 105 110 Met Ser Arg Asp Val Tyr Ser Tyr Leu Met Gln Gly Wing Met Leu Arg 115 120 125 Asp Gly Phe Asp Pro Tyr Thr Glu Gly Wing Wing Val Asn Pro Gly Pro 130 135 140 Met Leu Leu Glu Val Ser His Asp Trp Arg Asn Thr Thr Thr Pro Tyr 145 150 155 160 Gly Pro Leu His Leu Trp He Gly Asp Met He Thr Thr Val Val Gly 165 170 175 Asp Asn Val Thr Leu Gly Val Val Wing Tyr Lys He Leu Ser He He 180 185 190 Gly Leu Wing Val Thr Gly Trp Ser He Val Arg He Wing Gln His Phe 195 200 205 Gly Wing Asn Pro Wing He Wing Leu Trp He Gly Val Wing Asn Pro Val 210 215 220 Met He He His Met He Gly Gly Met His Asn Glu Ser Leu Met Val 225 230 235 240 Gly Leu Val Ser Val Gly Leu Leu Leu Ala Leu Ly s Lys Arg Phe Val 245 250 255 Wing Gly Val Wing Leu He Wing Val Wing Val Ser Leu Lys Wing Thr Wing 260 265 270 Wing Wing Wing Leu Pro Phe Val Val Trp He Gly Met His His Phe Wing 275 280 285 Gly Phe Leu Wing Thr Lys Lys Gly Lys Asp Ser Pro Thr Leu Lys Gln 290 295 300 Gln Val Pro Wing Phe Phe Wing Thr Gly Wing Wing Gly Val Wing Val Thr 305 310 315 320 Gly Val Val Val Ser Wing He Thr Trp Wing Ser Gly Wing Ser Trp Gly 325 330 335 Trp He Ser Glu He Ser Gly Asn Ser Lys Val He Asn Pro Leu Wing 340 345 350 Phe Pro Ser Leu Val Ala Ser Val He Thr Met Val Wing Glu Val Phe 355 360 365 Val Asp Asp Phe Asp Tyr Asn Wing Val Val Asn Val Val Arg Ser He 370 375 380 Ser Met Leu He Met Leu Gly Gly Leu Val Val Cys Trp Trp Leu Phe 385 390 395 400 Arg Gln Asn Glu Arg Arg Ala Val Thr Gly Thr Ala Ala Ala Tyr Ala 405 410 415 Val Ala Phe Val Phe Asn Ser Val Thr Leu Pro Trp Tyr Tyr Wing Ser 420 425 430 Leu He Ser Leu Leu Gly Thr Phe Lys Pro Pro Met Trp Leu He Arg 435 440 445 Phe Ala Ala Gly Ala Ser Val Phe He A the Leu Met Phe Thr Gly Ser 450 455 460 Gly Asn His Gln Leu Tyr Asn He Val Thr Val He He Wing Wing He 465 470 475 480 He Wing Trp Leu Wing Thr Val Val He Phe Asp Asp Thr Asp Pro Wing 485 490 495 Thr Thr Ala Thr Glu Lys Pro Ser Pro His Thr Val Ser 500 505 < 210 > 283 < 211 > 1298 < 212 > DNA < 213 > C < orynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (1275) < 223 > RXN01946 < 400 > 283 ate cgc aag tac tc agg etc gag gaa cat tcc cag tcg etc gcg ggc 48 He Arg Lys Tyr Ser Arg Leu Glu Glu Gln Phe Gln Ser Leu Gly Gly 1 5 10 15 tac gaa gct gac gcc gaa gca gcc cag ate tgc gac aac etc ggc etc 96 Tyr Glu Wing Asp Wing Glu Wing Wing Gln He Cys Asp Asn Leu Gly Leu 20 25 30 gag gca cgc ate etc gac cag cag ctt aaa acc ctg tcc ggc ggc cag 144 10 Glu Wing Arg He Leu Asp Gln Gln Leu Lys Thr Leu Ser Gly Gly Gln 35 40 45 cgc cgc cgc gtc gag ttg gcg cag ate etc ttc gcc gcc acc aac ggc 192 Arg Arg Arg Val Glu Leu Ala Gln He Leu Phe Ala Ala Thr Asn Gly • 50 55 60 tcc ggc aaa tea aaa tea here ttg ctt etc gac gag ccc acc aac falls 240 Ser Gly Lys Ser Lys Thr Thu Leu Leu Asu Glu Pro Thr Asn His 65 70 75 80 ttg gac gc gac tcg tcg tcg acc tc ctg ctg gcg aag falls 288 Leu Asp Wing Asp Ser He Thr Trp Leu Arg Asp Phe Leu Wing Lys His 85 90 95 gaa ggt gga ctg ate atg att tcg falls gac gtc gaa ctg ctt ggc gcc 336 Wing 15 Glu Gly Gly Leu He Met He Ser His Asp Val Glu Leu Leu Gly 100 105 110 gta tgt aac aag att tgg tac etc gac gca gta cgc age gaa gcc gat 384 Val Cys Asn Lys He Trp Tyr Leu Asp Wing Val Arg Ser Glu Wing Asp 115 120 125 gtc tac aac atg ggc ttt age aaa tac gtc gat gca cgt gca etc gat 432 Val Tyr Asn Met Gly Phe Ser Lys Tyr Val Asp Ala Arg Ala Leu Asp 130 135 140 gaa gca cgc cgc cgc cgt gag cgc gca aac gcc gaa aag aag gcc gga 480 • Glu Wing Arg Arg Arg Glu Arg Wing Asn Wing Glu Lys Lys Wing Gly 145 150 155 160 gcc etc aag gac cag gct gca cgc etc ggc gcg aaa gca acc aag gct 528 20 Wing Leu Lys Asp Gln Wing Wing Arg Leu Gly Wing Lys Wing Thr Lys Wing 165 170 175 gcc gca gct aag cag atg ate gcc cgt gcg gaa cga atg ate gac aac 576 Wing Wing Wing Lys Gln Met Wing Wing Arg Wing Glu Arg Met He Asp Asn 180 185 190 etc gac gaa ate cgc gta gct gac cgc gcc gcc aac ate gtt ttc cca 624 Leu Asp Glu He Arg Val Ala Asp Arg Ala Ala Asn He Val Phe Pro 195 200 205 'gaa gca cca tgt ccc gga aaa acc cca aac gcc aag etc ctg ggc acc 672 Ala Pro Glu Gly Lys Thr Pro Cys Asn Ala Pro Leu Lys Leu Gly Thr 210 215 220 aag tac ggc atg gtc ttc gaa aka etc gcc gcc ggc gtc gac cta tie 720 25 Lys Met Tyr Gly Ser Leu Glu Val Phe Wing Gly Val Asp Leu Wing He < - wAw? .-., Ai_ n,. ^ • & 225 230 235 240 gac aaa ggc tcc cgc gta gtc gtc etc gga ttc aac ggt gca ggt aaa 768 Asp Lys Gly Ser Arg Val Val Val Leu Gly Phe Asn Gly Ala Gly Lys 245 250 255 acc acc ctg etc aaa etc etc gcc ggt gtg gaa cgc acc gac ggc gaa 816 Thr Thr Leu Leu Lys Leu Leu Wing Gly Val Glu Arg Thr Asp Gly Glu 260 265 270 ggc ggc gtc gtc acc gga tac ggc etc aaa ate ggc tac tcc gcc cag 864 Gly Gly He Val Thr Gly Tyr Gly Leu Lys He Gly Tyr Phe Ala Gln • 275 280 285 gaa falls gac acc ate gac ccc gac aaa aka gtc tgg caa aac acc tie 912 Glu His Asp Thr He Asp Pro Asp Lys Ser Val Trp Gln Asn Thr He 290 295 300 gaa gcc tgc gcc gac gcc gc gac ca ca age etc cgc age etc etc gga 960 Glu Wing Cys Wing Asp Wing Asp Gln Gln Ser Leu Arg Ser Leu Leu Gly 305 310 315 320 tcc ttc atg ttc tcc ggc gaa caa etc gac caca cca gca gga here 1008 Ser Phe Met Phe Ser Gly Glu Gln Leu Asp Gln Pro Wing Gly Thr Leu 325 330 335 tcc ggt ggt gaa aaa acc cgc etc gca ctg gcc acc etc gtg tcc tcc 1056 10 Ser Gly Gly Glu L ys Thr Arg Leu Ala Leu Wing Thr Leu Val Ser Ser 340 345 350 cgc gca aac gtc ctg ctt etc gac gag ccc acc aac aac ctt gac ccg 1104 Arg Ala Asn Val Leu Leu Leu Asp Glu Pro Thr Asn Asn Leu Asp Pro 355 360 365 ate tcc cgc gaa cag gtc etc gac gca ctg cgc acc tac acc ggc gca 1152 He Ser Arg Glu Gln Val Leu Asp Ala Leu Arg Thr Tyr Thr Gly Wing 370 375 380 gtc gtc ctg gtt acc cae gac ccg ggt gca gtc aag gcc ctt cca gag 1200 Val Val Leu Val Thr His Asp Pro Gly Ala Val Lys Ala Leu Glu Pro 385 390 395 400 cgc gaa gtc ate gtg ctt ect gat ggc acc gag gat ctt tgg aat gat 1248 15 Glu Arg Val He Val Leu Pro Asp Gly Thr Glu Asp Leu Trp Asn Asp 405 410 415 cag tac atg gaa ate gtg gaa ttg gcg taggttctaa ggctgtttat 1295 Gln Tyr Met Glu He Val Glu Leu Wing 420 425 gct 1298 < 210 > 284 < 211 > 425 < 212 > PRT < 213 > Corynebact; epum glutamicum 20 < 400 > 284 He Arg Lys Tyr Ser Arg Leu Glu Glu Gln Phe Gln Ser Leu Gly Gly 1 5 10 15 Tyr Glu Wing Asp Wing Glu Wing Wing Gln He Cys Asp Asn Leu Gly Leu 20 25 30 Glu Wing Arg He Leu Asp Gln Gln Leu Lys Thr Leu Ser Gly Gly Gln 35 40 45 Arg Arg Arg Val Glu Leu Ala Gln He Leu Phe Ala Ala Thr Asn Gly 50 55 60 Ser Gly Lys Ser Lys Thr Thr Leu Leu Leu Asp Glu Pro Thr Asn His 65 70 75 80 Leu Asp Wing Asp Ser He Thr Trp Leu Arg Asp Phe Leu Wing Lys His 25 85 90 95 riii, Btr »*?» "» "Glu Gly Gly Leu He Met He Ser His Asp Val Glu Leu Leu Gly Wing 100 105 110 Val Cys Asn Lys He Trp Tyr Leu Asp Wing Val Arg Ser Glu Wing Asp 115 120 125 Val Tyr Asn Met Gly Phe Ser Lys Tyr Val Asp Wing Arg Wing Leu Asp 130 135 140 Glu Wing Arg Arg Arg Arg Glu Arg Wing Asn Wing Glu Lys Lys Wing Gly 145 150 155 160 Wing Leu Lys Asp Gln Wing Wing Arg Leu Gly Wing Lys Wing Thr Lys Wing • 165 170 175 Wing Wing Wing Lys Gln Met Wing Wing Arg Wing Glu Arg Met He Asp Asn 180 185 190 Leu Asp Glu He Arg Wing Wing Asp Arg Wing Wing Asn He Val Phe Pro 195 200 205 Glu Pro Wing Pro Cys Gly Lys Thr Pro Leu Asn Wing Lys Gly Leu Thr 210 215 220 Lys Met Tyr Gly Ser Leu Glu Val Phe Wing Gly Val Asp Leu Wing He 225 230 235 240 Asp Lys Gly Ser Arg Val Val Val Leu Gly Phe Asn Gly Ala Gly Lys 245 250 255 10 Thr Thr Leu Leu Lys Leu Leu Wing Gly Val Glu Arg Thr Asp Gly Glu 260 265 270 Gly Gly He Val Thr Gly Tyr Gly Leu Lys He Gly Tyr Phe Wing Gln 275 280 285 • Glu His Asp Thr He Asp Pro Asp Lys Ser Val Trp Gln Asn Thr He 290 295 300 Glu Ala Cys Wing Asp Wing Asp Gln Gln Ser Leu Arg Ser Leu Leu Gly 305 310 315 320 Ser Phe Met Phe Ser Gly Glu Gln Leu Asp Gln Pro Wing Gly Thr Leu 325 330 335 Ser Gly Gly Glu Lys Thr Arg Leu Ala Leu Ala Thr Leu Val Ser Ser 340 345 350 15 Arg Ala Asn Val Leu Leu Leu Asp Glu Pro Thr Asn Asn Leu Asp Pro 355 360 365 He Be Arg Glu Gln Val Leu Asp Ala Leu Arg Thr Tyr Thr Gly Wing 370 375 380 Val Val Leu Val Thr His Asp Pro Gly Ala Val Lys Ala Leu Glu Pro 385 390 395 400 Glu Arg Val He Val Leu Pro Asp Gly Thr Glu Asp Leu Trp Asn Asp 405 410 415 Gln Tyr Met Glu He Val Glu Leu Ala • 420 425 <; 210 > 285 20 < 211 > 1298 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (1275) < 223 > FRXA01946 < 400 > 285 ate cgc aag tac tc agg etc gag gaa cat tcc cag tcg etc ggc ggc 48 He Arg Lys Tyr Ser Arg Leu Glu Glu Gln Phe Gln Ser Leu Gly Gly 25 1 5 10 15 . á áuÁ? tac gaa gct gac gcc gaa gcc gcc cag ate tgc gac aac etc ggc etc 96 Tyr Glu Wing Asp Wing Glu Wing Wing Gln He Cys Asp Asn Leu Gly Leu 20 25 30 gag gca cgc ate etc gac cag cag ctt aaa acc ctg tcc ggc ggc cag 144 Glu Wing Arg He Leu Asp Gln Gln Leu Lys Thr Leu Ser Gly Gly Gln 35 40 45 cgc cgc cgc gtc gag ttg gcg cag ate etc ttc gcc gcc acc aac ggc 192 Arg Arg Arg Val Glu Leu Ala Gln He Leu Phe Wing Wing Thr Asn Gly • 50 55 60 tcc ggc aaa tea aaa ttg ac ttg ctt etc gac gag ccc acc aac falls 240 Ser Gly Lys Ser Lys Thr Thu Leu Leu Leu Asp Glu Pro Thr Asn His 65 70 75 80 ttg gac gca gac tcg ate acc tgg etc cgt gac ttc ctg gcg aag drops 288 Leu Asp Wing Asp Ser He Thr Trp Leu Arg Asp Phe Leu Wing Lys His 85 90 95 gaa ggt ggt gt ctg ate atg att tcg gc gtc gaa ctg ctt ggc gcc 336 Glu Gly Gly Leu He Met He Ser His Asp Val Glu Leu Leu Gly Ala 100 105 110 gta tgt aac aag att tgg tac etc gac gca gta cgc age gaa gcc gat 384 Val Cys Asn Lys He Trp Tyr Leu Asp Ala Val Arg Ser Glu Ala Asp 10 115 120 125 gtc tac aac atg ggc ttt age aaa tac gtc gat gca cgt gca etc gat 432 Val Tyr Asn Met Gly Phe Ser Lys Tyr Val Asp Ala Arg Ala Leu Asp 130 135 140 • gaa gca cgc cga cgc cgt gag cgc gca aac gcc gaa aag aag gcc gga 480 Glu Wing Arg Arg Arg Glu Arg Wing Asn Wing Glu Lys Lys Wing Gly 145 150 155 160 gcc etc aag gac cag gct gca cgc etc ggc gcg aaa gca acc aag gct 528 Ala Leu Lys Asp Gln Wing Wing Arg Leu Gly Wing Lys Wing Wing Lys Wing 165 170 175 gcc gca gct aag cag atg ate gcc cgt gcg gaa cga atg ate gac aac 576 Wing Wing Lys Gln Met Wing Wing Arg Wing Glu Arg Met He Asp Asn 15 180 185 190 etc gac gaa ate cgc gta gct gac cgc gcc gcc aac ate gtt tcc cca 624 Leu Asp Glu He Arg Val Wing Asp Arg Wing Wing Asn He Val Phe Pro 195 200 205 gaa cca gca ccc tgt gga aaa acc cca etc aac gcc aag ggc ctg acc 672 Glu Pro Wing Pro Cys Gly Lys Thr Pro Leu Asn Wing Lys Gly Leu Thr 210 215 220 aag atg tac ggc tcc etc gaa gtc tcc gcc gcc gcc gac cta gcc ate 720 • Lys Met Tyr Gly Ser Leu Glu Val Phe Wing Gly Val Asp Leu Wing He 225 230 235 240 gac aaa ggc tcc cgc gta gtc gtc etc gga ttc aac ggt gca ggt aaa 768 Asp Lys Gly Ser Arg Val Val Val Leu Gly Phe Asn Gly Wing Gly Lys 20 245 250 255 acc acc ctg etc aaa etc etc gcc ggt gtg gaa cgc acc gac ggc gaa 816 Thr Thr Leu Leu Lys Leu Leu Wing Gly Val Glu Arg Thr Asp Gly Glu 260 265 270 ggc ggc gtc gtc acc gga tac ggc etc aaa ate ggc tac tc gcc cag 864 Gly Gly He Val Thr Gly Tyr Gly Leu Lys He Gly Tyr Phe Ala Gln 275 280 285 gaa falls gac acc ate gac ccc gac aaa tcc gtc tgg ca a aac acc ate 912 Glu His Asp Thr He Asp Pro Asp Lys Ser Val Trp Gln Asn Thr He 290 295 300 gaa gcc tgc gcc gac gcc gac caá caá age etc cgc age etc etc gga 960 Glu Ala Cys Wing Asp Wing Asp Gln Gln Ser Leu Arg Ser Leu Leu Gly 25 305 310 315 320 tcc ttc atg ttc tcc ggc gaa caa etc gac caca cca gca gga here etc 100Í Be Phe Met Phe Be Gly Glu Gln Leu Asp Gln Pro Wing Gly Thr Leu 325 330 335 tcc ggc ggt gaa aaa acc cgc etc gca ctg gcc acc etc gtg tcc tcc 1056 Be Gly Gly Glu Lys Thr Arg Leu Wing Leu Wing Thr Leu Val Ser Ser 340 345 350 cgc gca aac gtc ctg ctt etc gac gag ccc acc aac aac ctt gac ccg 1104 Arg Ala Asn Val Leu Leu Leu Asp Glu Pro Thr Asn Asn Leu Asp Pro 355 360 365 ate tcc cgc gaa cag gtc etc gac gca ctg cgc acc tac acc ggc gca 1152 He is Arg Glu Gln Val Leu Asp Ala Leu Arg Thr Tyr Thr Gly Wing 370 375 380 gtc gtc gtc ctg gtt acc gac ccg ggt gca gtc aag gcc ctt gag cca 1200 Val Val Leu Val Thr His Asp Pro Gly Ala Val Lys Ala Leu Glu Pro 385 390 395 400 gaa cgc gtc ate gtg ctt ect gat ggc acc gag gat ctt tgg aat gat 1248 Glu Arg Val He Val Leu Pro Asp Gly Thr Glu Asp Leu Trp Asn Asp 405 410 415 cag tac atg gaa ate gtg gaa ttg gcg taggttctaa ggctgtttat 1295 Gln Tyr Met Glu He Val Glu Leu Wing 420 425 gct 1298 < 210 > 286 < 211 > 425 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 286 He Arg Lys Tyr Ser Arg Leu Glu Glu Gln Phe Gln Ser Leu Gly Gly 1 5 10 15 Tyr Glu Wing Asp Wing Glu Wing Wing Gln He Cys Asp Asn Leu Gly Leu 20 25 30 Glu Wing Arg He Leu Asp Gln Gln Leu Lys Thr Leu Ser Gly Gly Gln 35 40 45 Arg Arg Arg Val Glu Leu Ala Gln He Leu Phe Ala Ala Thr Asn Gly 50 55 60 Ser Gly Lys Ser Lys Thr Thr Leu Leu Leu Asp Glu Pro Thr Asn His 65 70 75 80 Leu Asp Wing Asp Ser He Thr Trp Leu Arg Asp Phe Leu Wing Lys His 85 90 95 Glu Gly Gly Leu He Met He Ser His Asp Val Glu Leu Leu Gly Wing 100 105 110 Val Cys Asn Lys He Trp Tyr Leu Asp Wing Val Arg Ser Glu Wing Asp 115 120 125 Val Tyr Asn Met Gly Phe Ser Lys Tyr Val Asp Wing Arg Wing Leu Asp 130 135 140 Glu Wing Arg Arg Arg Glu Arg Wing Asn Wing Glu Lys Lys Wing Gly 145 150 155 160 Wing Leu Lys Asp Gln Wing Wing Arg Leu Gly Wing Lys Wing Thr Lys Wing 165 170 175 Wing Wing Wing Lys Gln Met Wing Wing Arg Wing Glu Arg Met He Asp Asn 180 185 190 Leu Asp Glu He Arg Wing Wing Asp Arg Wing Wing Asn He Val Phe Pro 195 200 205 Glu Pr or Wing Pro Cys Gly Lys Thr Pro Leu Asn Wing Lys Gly Leu Thr 210 215 220 «*, * & »I- ^ n ^ Lys Met Tyr Gly Ser Leu Glu Val Phe Wing Gly Val Asp Leu Wing He 225 230 235 240 Asp Lys Gly Ser Arg Val Val Val Leu Gly Phe Asn Gly Wing Gly Lys 245 250 255 Thr Thr Leu Leu Lys Leu Leu Ala Gly Val Glu Arg Thr Asp Gly Glu 260 265 270 Gly Gly He Val Thr Gly Tyr Gly Leu Lys He Gly Tyr Phe Wing Gln 275 280 285 Glu His Asp Thr He Asp Pro Asp Lys Ser Val Trp Gln Asn Thr He • 290 295 300 Glu Wing Cys Wing Asp Wing Asp Gln Gln Ser Leu Arg Ser Leu Leu Gly 305 310 315 320 Ser Phe Met Phe Ser Gly Glu Gln Leu Asp Gln Pro Wing Gly Thr Leu 325 330 335 Ser Gly Gly Glu Lys Thr Arg Leu Ala Leu Ala Thr Leu Val Ser Ser 340 345 350 Arg Ala Asn Val Leu Leu Leu Asp Glu Pro Thr Asn Asn Leu Asp Pro 355 360 365 He Be Arg Glu Gln Val Leu Asp Ala Leu Arg Thr Tyr Thr Gly Wing 370 375 380 10 Val Val Leu Val Thr His Asp Pro Gly Ala Val Lys Ala Leu Glu Pro 385 390 395 400 Glu Arg Val He Val Leu Pro Asp Gly Thr Glu Asp Leu Trp Asn Asp 405 410 415 Gln Tyr Met Glu He Val Glu Leu Wing 420 42 5 < 210 > 287 < 211 > 1812 < 212 > DNA < 213 > Corynebacterium glutamicum 15 < 220 > < 221 > CDS < 222 > (101) .. (1789) < 223 > RXN00164 < 400 > 287 ctgctttgcg < ggaggttatg aaatgagtgg ggagaegteg aaaagcatgc < gcttl: ccgtt 60 ggccagcctg < ccgcaagtgc ggcgcgaggt ggcccggcag gtg ggt cgt att ccg 115 Val Gly Arg He Pro 1 5 cgg gcg aag tgg tgg ttt tta ggc gcg ctg gtg ttg ctg agt gcg ggc 163 Arg Ala Lys Trp Trp Phe Leu Gly Ala Leu Val Leu Leu Ser Ala Gly 20 10 15 20 gct tat gcg tcg gtg ctg gtg ccg cag gtg ctg ggg cgg att gtg gat 211 Wing Tyr Wing Being Val Leu Val Pro Gln Val Leu Gly Arg He Val Asp 25 30 35 ctg gtg tcc gat ggc gcg cag atg cgt gat ttt gtt gag etc agt gtg 259 Leu Val Ser Asp Gly Wing Gln Met Arg Asp Phe Val Glu Leu Ser Val 40 45 50 att etc att gcg gtg gca att gcc ggc gcg gtg etc agt gcg tgc ggg 307 He Leu He Ala Ala Ala Ala Gly Ala Val Leu Ser Ala Cys Gly 55 60 65 ttc tat gtg gtg tcg cgg att tet gag aag att ate gcc aat ttg agg 355 Phe Tyr Val Val Ser Arg He Ser Glu Lys He He Wing Asn Leu Arg 25 70 75 80 85 » ^. ^ - A. * > ^ -. gaa gat atg gtg ggc acc gcg ctt ggg ttg ccc acg falls cag gtg gaa 403 Glu Asp Met Val Gly Thr Ala Leu Gly Leu Pro Thr His Gln Val Glu 90 95 100 gat gcg ggc tet ggc gat ttg gtg age cgc tcc acc gat gat gtc tcc 451 Asp Ala Gly Ser Gly Asp Leu Val Ser Arg Ser Thr Asp Asp Val Ser 105 110 115 gag cta tcc gca gcg gtg here gag acc gtc ccg att tta agt tcc tea 499 Glu Leu Ser Wing Wing Val Thr Glu Thr Val Pro He Leu Ser Be Ser • 120 125 130 ctg ttt acc att gcc gcg acg ate att gcg ctg ttt tet ttg gac tgg 547 Leu Phe Thr He Wing Wing Thr He He Wing Wing Leu Phe Ser Leu Asp Trp 135 140 145 caat ttt gtg etc att ect gtc gtg gtg gcg ccg gtg tac tac tcc gcg 595 Gln Phe Val Leu He Pro Val Val Val Val Pro Wing Val Tyr Tyr Phe Wing 150 155 160 165 tcc aag falls tat ttg age aag gcg ccg gat cgg tat gcg gca gaa cgc 643 Ser Lys His Tyr Leu Ser Lys Wing Pro Asp Arg Tyr Ala Wing Glu Arg 170 175 180 gcg gcg atg gcg gag cgt gcg cga aag gta ctt gag gct att cgc ggg 691 Wing Wing Met Wing Glu Arg Wing Arg Lys Val Leu Glu Wing He Arg Gly 185 190 195 10 cgt gca act gtg cgg gcg tat tcc atg gaa gat gcc atg cat aat cag 739 Arg Ala Thr Val Arg Ala Tyr Ser Met Glu Asp Ala Met His Asn Gln • 200 205 210 att gat cag gcg tcg tgg tet gtg gtg gtc aag ggt att cgt gcg cgc 787 He Asp Gln Wing Ser Trp Ser Val Val Val Lys Gly He Arg Wing Arg 215 220 225 acc acc atg ttg att ttg aac atg tgg atg ctg ttt gcg gaa ttc etc 835 Thr Thr Met Leu He Leu Asn Met Trp Met Leu Phe Wing Glu Phe Leu 230 235 240 245 atg etc gcg gtc gcg ttg gtg ate ggc tac aag ctg gtc att gat aat 883 Met Leu Ala Val Ala Leu Val He Gly Tyr Lys Leu Val He Asp Asn 250 255 260 15 gcg ctg acg ate ggc gcg gtt acc ggt gcc gtg ctg atg att cgt 931 Wing Leu Thr He Gly Wing Val Thr Gly Wing Val Leu Met He He Arg 265 270 275 ctg cgt ggc ccg atg atat atg ttc atg cgc gtg etc gac acc att caá 979 Leu Arg Gly Pro Met Met Met Met Met Phe met Arg Val Leu Asp Thr Met Gln 280 285 290 tcc ggc tat gcg tcg ctg gcg cgc ate gtg gga gtt gtt gcg gat ccg 1027 • Ser Gly Tyr Ala Ser Leu Ala Arg He Val Gly Val Val Ala Asp Pro 295 300 305 ccg att ect gtg ccc gac age ggt gtg aaa gca ect cag ggc aaa gtg 1075 Pro He Pro Val Pro Asp Ser Gly Val Lys Pro Wing Gln Gly Lys Val 20 310 315 320 325 gaa ttg cgc aac gtc age ttt age tat ggc gat tcc tgg gcg gtg aaa 1123 Glu Leu Arg Asn Val Ser Phe Ser Tyr Gly Asp Ser Trp Wing Val Lys 330 335 340 gac ate gac ate acg ate aat tcc ggc gaa act gtc gcg etc gtg ggc 1171 Asp He Asp He Thr He Asn Ser Gly Glu Thr Val Wing Leu Val Gly 345 350 355 gca tet ggc gca ggt aag acg acg gtc gcc gcc ttg ctg gcg ggc ttg 1219 Wing Ser Gly Wing Gly Lys Thr Thr Val Wing Wing Leu Leu Wing Gly Leu 360 365 370 cgg gtg cca gat ca ggg c gtg ctt gtc gac gac ttc ccc gtc tet 1267 Arg Val Pro Asp Gln Gly Gln Val Leu Val Asp Asp Phe Pro Val Ser 25 375 380 385 falls etc tet gac cgc gag cgt ate gcc cgc ttg gcc atg gtc age cag 1315 His Leu Ser Asp Arg Glu Arg He Wing Arg Leu Wing Met Val Ser Gln 390 395 400 405 gag gtt cat gtt ttc tcc ggc acg ctg cgc cag gat etc acc ttg gct 1363 Glu Val His Val Phe Ser Gly Thr Leu Arg Gln Asp Leu Thr Leu Wing 410 415 420 aaa cca gat gcc tcc gat gag gata tta gcg cat gct ctt ggg ca gtt 1411 Lys Pro Asp Wing Ser Asp Glu Glu Leu Wing His Wing Leu Gly Gln Val 425 430 435 • aat gcc ctt gac tgg ttg gag agt ctt cca gaa gga ctg gac acg gtc 1459 Asn Ala Leu Asp Trp Leu Glu Ser Leu Pro Glu Gly Leu Asp Thr Val 440 445 450 gtt gg gcg cga gga ate cag cta gaa cca gtg gtg gct cag cag ttg 1507 Val Gly Wing Arg Gly He Gln Leu Glu Pro Val Val Wing Gln Gln Leu 455 460 465 gcg ttg gcc cgg gtg ttg ttg etc aat ccg gcg ate gtc ate atg gat 1555 Ala Leu Ala Arg Val Leu Leu Leu Asn Pro Ala He Val He Met Asp 470 475 480 485 gaa gcc acg gca gaa gca gga tcg gcg ggt gcc age gca ctg gaa gag 1603 Glu Ala Thr Ala Glu Ala Gly Be Ala Ala Gly Ala Be Ala Leu Glu Glu 10 490 495 500 gct gca gat gca gtg age aag aac cgt tcc gca ttg gtg gtg gcg cae 1651 Ala Ala Asp Ala Val Ser Lys Asn Arg Ser Ala Leu Val Val Ala His 505 510 515 • cgg ttg gat cag gca tcg cgg gct gat cag att ctg gtg atg gat aag 1699 Arg Leu Asp Gln Wing Being Arg Wing Asp Gln He Leu Val Met Asp Lys 520 525 530 ggg gag gtt gtg gaa tcc ggt act falls cag gag tta ttg gat falls ggg 1747 Gly Glu Val Val Glu Ser Gly Thr His Gln Glu Leu Leu Asp His Gly 535 540 545 ggt att tat cag cgt ctg tgg act gcg tgg agt gtc gga aga 1789 Gly He Tyr Gln Arg Leu Trp Thr Wing Trp Ser Val Gly Arg 15 550 555 560 tagtitgactg ttcaatgcgt tga 1812 < 210 > 288 < 211 > 563 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 288 • Val Gly Arg He Pro Arg Wing Lys Trp Trp Phe Leu Gly Wing Leu Val 1 5 10 15 Leu Leu Ser Wing Gly Wing Tyr Wing Being Val Leu Val Pro Gln Val Leu 20 20 25 30 Gly Arg He Val Asp Leu Val Ser Asp Gly Ala Gln Met Arg Asp Phe 35 40 45 Val Glu Leu Ser Val He Leu He Ala Val Ala He Ala Gly Ala Val 50 55 60 Leu Ser Ala Cys Gly Phe Tyr Val Val Ser Arg He Ser Glu Lys He 65 70 75 80 He Wing Asn Leu Arg Glu Asp Met Val Gly Thr Wing Leu Gly Leu Pro 85 90 95 Thr His Gln Val Glu Asp Wing Gly Ser Gly Asp Leu Val Ser Arg Ser 100 105 110 Thr Asp Asp Val Ser Glu Leu Ser Wing Ala Val Thr Glu Thr Val Pro 25 115 120 125 He Leu Being Ser Leu Phe Thr He Ala Wing Thr He He Wing Leu 130 135 140 Phe Ser Leu Asp Trp Gln Phe Val Leu He Pro Val Val Val Wing Pro 145 150 155 160 Val Tyr Tyr Phe Ala Ser Lys His Tyr Leu Ser Lys Ala Pro Asp Arg 165 170 175 Tyr Ala Ala Glu Arg Ala Ala Met Ala Glu Arg Ala Arg Lys Val Leu 180 185 190 • Glu Ala He Arg Gly Arg Ala Thr Val Arg Ala Tyr Ser Met Glu Asp 195 200 205 Met Wing His Asn Gln He Asp Gln Wing Ser Trp Ser Val Val Val Lys 210 215 220 Gly He Arg Wing Arg Thr Thr Met Leu He Leu Asn Met Trp Met Leu 225 230 235 240 Phe Ala Glu Phe Leu Met Leu Ala Val Wing Leu Val He Gly Tyr Lys 245 250 255 Leu Val He Asp Asn Wing Leu Thr He Gly Wing Val Thr Gly Wing Val 260 265 270 Leu Met He He Arg Leu Arg Gly Pro Met As Met Met Phe Met Arg Val 275 280 285 10 Leu Asp Thr He Gln Ser Gly Tyr Wing Ser Leu Wing Arg He Val Gly 290 295 300 Val Val Wing Asp Pro Pro He Pro Val Pro Asp Ser Gly Val Lys Wing 305 310 315 320 Pro Gln Gly Lys Val Glu Leu Arg Asn Val Ser Phe Ser Tyr Gly Asp 325 330 335 Ser Trp Wing Val Lys Asp He Asp He Thr He Asn Ser Gly Glu Thr 340 345 350 Val Wing Leu Val Gly Wing Ser Gly Wing Gly Lys Thr Thr Val Wing Wing 355 360 365 Leu Leu Wing Gly Leu Arg Val Pro Asp Gln Gly Gln Val Leu Val Asp 370 375 380 15 Asp Phe Pro Val Ser His Leu Ser Asp Arg Glu Arg He Wing Arg Leu 385 390 395 400 Wing Met Val Ser Gln Val Val His Val Phe Ser Gly Thr Leu Arg Gln 405 410 415 Asp Leu Thr Leu Wing Lys Pro Asp Wing Ser Asp Glu Glu Leu Wing His 420 425 430 Wing Leu Gly Gln Val Asn Wing Leu Asp Trp Leu Glu Ser Leu Pro Glu 435 440 445 Gly Leu Asp Thr Val Val Gly Wing Arg Gly He Gln Leu Glu Pro Val 450 455 460 Val Wing Gln Gln Leu Wing Leu Wing Arg Val Leu Leu Leu Asn Pro Wing 465 470 475 480 20 He Val He Met Asp Glu Wing Thr Wing Glu Wing Gly Being Wing Gly Wing 485 490 495 Be Ala Leu Glu Glu Ala Ala Asp Ala Val Ser Lys Asn Arg Be Ala 500 505 510 Leu Val Val Ala His Arg Leu Asp Gln Ala Ser Arg Ala Asp Gln He 515 520 525 Leu Val Met Asp Lys Gly Val Glu Val Glu Ser Gly Thr His Gln Glu 530 535 540 Leu Leu Asp His Gly Gly He Tyr Gln Arg Leu Trp Thr Wing Trp Ser 545 550 555 560 Val Gly Arg 25 < 210 > 289 . Jh ** > * & ^, < 211 > 1812 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1789) < 223 > FRXA00164 < 400 > 289 ctgctttigcg iggaggttatg aaatg; agtgg gg, agacgtcg aaaagcatgc < gctttccgtt 60 ggccagcictg iccgcaagtgc ggcgcgaggt ggicccggcag gtg ggt cgt att ccg 115 Val Gly Arg He Pro 1 5 cgg gcg aag tgg tgg ttt tta ggc gcg ctg gtg ttg ctg agt gcg ggc 163 Arg Ala Lys Trp Trp Phe Leu Gly Wing Leu Val Leu Leu Ser Wing Gly 10 15 20 gct tat gcg tcg gtg ctg gtg ccg cag gtg ctg ggg cgg att gtg gat 211 Ala Tyr Ala Ser Val Leu Val Pro Gln Val Leu Gly Arg He Val Asp 25 30 35 ctg gtg tcc gat ggc gcg cag atg cgt gat ttt gtt gag etc agt gtg 259 Leu Val Ser Asp Gly Wing Gln Met Arg Asp Phe Val Glu Leu Ser Val 40 45 50 att etc att gcg gtg gca att gcc ggc gcg gtg etc agt gcg tgc ggg 307 He Leu He Ala Ala Ala He Ala Gly Ala Val Leu Ser Ala Cys Gly 55 60 65 ttc tat gtg gtg tcg cgg att tet gag aag att ate gcc aat ttg agg 355 Phe Tyr Val Val Ser Arg He Ser Glu Lys He He Wing Asn Leu Arg 70 75 80 85 gaa gat atg gtg ggc acc gcg ctt ggg ttg ccc acg falls cag gtg gaa 403 Glu Asp Met Val Gly Thr Ala Leu Gly Leu Pro Thr His Gln Val Glu 90 95 100 gat gcg ggc tet ggc gat ttg gtg age cgc tcc acc gat gat gtc tcc 451 Asp Ala Gly Ser Gly Asp Leu Val Ser Arg Ser Thr Asp Asp Val Ser 105 110 115 gag cta tcc gca gcg gtg here gag acc gtc ccg att tta agt tcc tea 499 Glu Leu Ser Wing Wing Val Thr Glu Thr Val Pro He Leu Ser Be Ser 120 125 130 ctg ttt acc att gcc gcg acg ate att gcg ctg ttt tet ttg gac tgg 547 Leu Phe Thr He Wing Wing Thr He He Wing Wing Leu Phe Ser Leu Asp Trp 135 140 145 caat ttt gtg etc att ect gtc gtg gtg gcg ccg gtg tac tac tcc gcg 595 Gln Phe Val Leu He Pro Val Val Val Ala Pro Val Tyr Tyr Phe Ala 150 155 160 165 tcc aag falls tat ttg age aag gcg ccg gat cgg tat gcg gca gaa cgc 643 Ser Lys His Tyr Leu Ser Lys Wing Pro Asp Arg Tyr Ala Wing Glu Arg 170 175 180 gcg gcg atg gcg gag cgt gcg cga aag gta ctt gag gct att cgc ggg 691 Wing Wing Met Wing Glu Arg Wing Arg Lys Val Leu Glu Wing He Arg Gly 185 190 195 cgt gca act gtg cgg gcg tat tcc atg gaa gat gcc atg cat aat cag 739 Arg Ala Thr Val Arg Ala Tyr Ser Met Glu Asp Ala Met His Asn Gln 200 205 210 att gat cag gcg tcg tgg tet gtg gtg gtc aag ggt att cgt gcg cgc 787 He Asp Gln Wing Ser Trp Ser Val Val Val Lys Gly He Arg Wing Arg 215 220 225 acc acc atg ttg att ttg aac atg tgg atg ctg ttt gcg gaa ttc etc 835 Thr Thr Met Leu He Leu Asn Met Trp Met Leu Phe Wing Glu Phe Leu 230 235 240 245 atg etc gcg gtc gcg ttg gtg ate ggc tac aag ctg gtc att gat aat 883 Met Leu Ala Val Ala Leu Val He Gly Tyr Lys Leu Val He Asp Asn 250 255 260 gcg ctg acg ate ggc gcg gtt acc ggt gcc gtg ctg atg att cgt 931 Wing Leu Thr He Gly Wing Val Thr Gly Wing Val Leu Met He He Arg 265 270 275 ctg cgt ggc ccg atg atat atg ttc atg cgc gtg etc gac acc att caá 979 Leu Arg Gly Pro Met Met Met Met Met Phe met Arg Val Leu Asp Thr Met Gln 280 285 290 tcc ggc tat gcg tcg ctg gcg cgc ate gtg gga gtt gtt gcg gat ccg 1027 Ser Gly Tyr Ala Ser Leu Ala Arg He Val Gly Val Val Ala Asp Pro 295 300 305 ccg att ect gtg ccc gac age ggt gtg aaa gca ect cag ggc aaa gtg 1075 Pro He Pro Val Pro Asp Ser Gly Val Lys Pro Wing Gln Gly Lys Val 310 315 320 325 gaa ttg cgc aac gtc age ttt age tat ggc gat tcc tgg gcg gtg aaa 1123 Glu Leu Arg Asn Val Ser Phe Ser Tyr Gly Asp Ser Trp Wing Val Lys 330 335 340 10 gac ate gac ate acg ate aat tcc ggc gaa act gtc gcg etc gtg ggc 1171 Asp He Asp He Thr He Asn Ser Gly Glu Thr Val Wing Leu Val Gly 345 350 355 gca tet ggc gca ggt aag acg acg gtc gcc gcc ttg ctg gcg ggc ttg 1219 • Wing Ser Gly Wing Gly Lys Thr Thr Val Wing Wing Leu Leu Wing Gly Leu 360 365 370 cgg gtg cca gat ca ggg c gtg ctt gtc gac gac ttc ccc gtc tet 1267 Arg Val Pro Asp Gln Gly Gln Val Leu Val Asp Asp Phe Pro Val Ser 375 380 385 falls etc tet gac cgc gag cgt ate gcc cgc ttg gcc atg gtc age cag 1315 His Leu Being Asp Arg Glu Arg He Wing Arg Leu Wing Met Val Ser Gln 390 395 400 405 15 gag gtt cat gtt tcc tcc ggc acg ctg cgc cag gat etc acc ttg gct 1363 Glu Val His Val Phe Ser Gly Thr Leu Arg Gln Asp Leu Thr Leu Wing 410 415 420 aaa cca gat gcc tcc gat gag gata tta gcg cat gct ctt ggg ca gtt 1411 Lys Pro Asp Wing Ser Asp Glu Glu Leu Wing His Wing Leu Gly Gln Val 425 430 435 aat gcc ctt gac tgg ttg gag agt ctt cca gaa gga ctg gac acg gtc 1459 Asn Ala Leu Asp Trp Leu Glu Ser Leu Pro Glu Gly Leu Asp Thr Val 440 445 450 • gtt ggt gg gga cga gga ate cag cta gaga cca gtg gtg gct cag cag ttg 1507 Val Gly Wing Arg Gly He Gln Leu Glu Pro Val Val Wing Gln Gln Leu 455 460 465 20 gcg ttg gcc cgg gtg ttg ttg etc aat ccg gcg ate gtc ate atg gat 1555 Ala Leu Ala Arg Val Leu Leu Leu Asn Pro Ala He Val He Met Asp 470 475 480 485 gaa gcc acg gca gaa gca gga tcg gcg ggt gcc age gca ctg gaa gag 1603 Glu Ala Thr Ala Glu Ala Gly Be Ala Gly Ala Be Ala Leu Glu Glu 490 495 500 gct gca gat gca gtg age aag aac cgt tcc gca ttg gtg gtg gcg cae 1651 Ala Ala Asp Ala Val Ser Lys Asn Arg Ser Ala Leu Val Val Ala His 505 510 515 cgg ttg gat cag gca tcg cgg gct gat cag att ctg gtg atg gat aag 1699 Arg Leu Asp Gln Wing Wing Arg Wing Asp Gln He Leu Val Met Asp Lys 520 525 530 25 ggg gag gtt gtg gaa tc ggt act falls cag gag tta ttg gat falls ggg 1747 Gly Glu Val Val Glu Ser Gly Thr His Gln Glu Leu Leu Asp His Gly 535 540 545 ggt att tat cag cgt ctg tgg act gcg tgg agt gtc gga aga 1789 Gly He Tyr Gln Arg Leu Trp Thr Wing Trp Ser Val Gly Arg 550 555 560 tagttgactg ttcaatgcgt tga 1812 < 210 > 290 < 211 > 563 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 290 Val Gly Arg He Pro Arg Ala Lys Trp Trp Phe Leu Gly Ala Leu Val 1 5 10 15 Leu Leu Ser Ala Gly Ala Tyr Ala Ser Val Leu Val Pro Gln Val Leu 20 25 30 Gly Arg He Val Asp Leu Val Ser Asp Gly Wing Gln Met Arg Asp Phe 35 40 45 Val Glu Leu Ser Val He Leu He Wing Val Wing Wing Wing Gly Wing Val 55 55 60 Leu Ser Wing Cys Gly Phe Tyr Val Val Ser Arg He Ser Glu Lys He 65 70 75 80 He Wing Asn Leu Arg Glu Asp Met Val Gly Thr Ala Leu Gly Leu Pro 85 90 95 Thr His Gln Val Glu Asp Ala Gly Ser Gly Asp Leu Val Ser Arg Ser 100 105 110 Thr Asp Asp Val Ser Glu Leu Ser Ala Ala Val Thr Glu Thr Val Pro. 115 120 125 He Leu Being Ser Leu Phe Thr He Ala Wing Thr He He Wing Leu 130 135 140 Phe Ser Leu Asp Trp Gln Phe Val Leu He Pro Val Val Val Wing Pro 145 150 155 160 Val Tyr Tyr Phe Wing Ser Lys His Tyr Leu Ser Lys Wing Pro Asp Arg 165 170 175 Tyr Wing Wing Wing Arg Wing Wing Wing Wing Wing Arg Wing Arg Lys Val Leu 180 185 190 Glu Wing He Arg Gly Arg Wing Thr Val Arg Wing Tyr Ser Met Glu Asp 195 200 205 Wing Met His Asn Gln He Asp Gln Wing Ser Trp Ser Val Val Val Lys 210 215 220 Gly He Arg Wing Arg Thr Thr Met Leu He Leu Asn Met Trp Met Leu 225 230 235 240 Phe Ala Glu Phe Leu Met Leu Ala Val Ala Leu Val He Gly Tyr Lys 245 250 255 Leu Val He Asp Asn Ala Leu Thr He Gly Wing Val Thr Gly Wing Val 260 265 270 Leu Met He He Arg Leu Arg Gly Pro Met As Met Met Phe Met Arg Val 275 280 285 Leu Asp Thr He Gln Ser Gly Tyr Wing Ser Leu Wing Arg He Val Gly 290 295 300 Val Val Wing Asp Pro Pro He Pro Val Pro Asp Ser Gly Val Lys Wing 305 310 315 320 Pro Gln Gly Lys Val Glu Leu Arg Asn Val Ser Phe Ser Tyr Gly A sp 325 330 335 Ser Trp Wing Val Lys Asp He Asp He Thr He Asn Ser Gly Glu Thr 340 345 350 ^ g ^ m ^ gl Val Ala Leu Val Gly Wing Ser Gly Wing Gly Lys Thr Thr Val Wing Wing 355 360 365 Leu Leu Wing Gly Leu Arg Val Pro Asp Gln Gly Gln Val Leu Val Asp 370 375 380 Asp Phe Pro Val Ser His Leu Ser Asp Arg Glu Arg He Wing Arg Leu 385 390 395 400 Wing Met Val Ser Gln Val Val His Val Phe Ser Gly Thr Leu Arg Gln 405 410 415 Asp Leu Thr Leu Wing Lys Pro Asp Wing Ser Asp Glu Glu Leu Wing His • 420 425 430 Wing Leu Gly Gln Val Asn Wing Leu Asp Trp Leu Glu Ser Leu Pro Glu 435 440 445 Gly Leu Asp Thr Val Val Gly Wing Arg Gly He Gln Leu Glu Pro Val 450 455 460 Val Wing Gln Gln Leu Wing Leu Wing Arg Val Leu Leu Leu Asn Pro Wing 465 470 475 480 He Val He Met Asp Glu Wing Thr Wing Glu Wing Gly Wing Wing Gly Wing 485 490 495 Wing Wing Leu Glu Wing Wing Wing Asp Wing Val Ser Lys Asn Arg Wing Wing 500 505 510 Leu Val Val Wing His Arg Leu Asp Gln Wing Wing Arg Wing Asp Gln He 10 515 520 525 Leu Val Met Asp Lys Gly Glu Val Val Glu Ser Gly Thr His Gln Glu 530 535 540 • Leu Leu Asp His Gly Gly He Tyr Gln Arg Leu Trp Thr Ala Trp Ser 545 550 555 560 Val Gly Arg <; 210 > 291 < 211 > 1140 < 212 > DNA < 213 > Corynebacterium glutamicum 15 < 220 > < 221 > CDS < 222 > (101) .. (1117) < 223 > RXN00243 < 400 > 291 cactgcgcca < gatttttgat gccgacactg tggeaggtgt gcgcgctgag tacgaaaaat 60 ttaacaaagc; agcccatgat ggaaatgaag aggaacagaa gtg acc age gaa caa 115 • Val Thr Ser Glu Gln 1 5 gct tta gat ect ate falls cca ggt cag ttc cgt ctt tet cgg att cag 163 20 Ala Leu Asp Pro He His Pro Gly Gln Phe Arg Leu Ser Arg He Gln 10 15 20 ttg ate aac tgg gga acc ttc cae gga acg gtg gac att ect gtg acc 211 Leu He Asn Trp Gly Thr Phe His Gly Thr Val Asp He Pro Val Thr 25 30 35 agg gaa gga ate tta gtt acc ggt ggt tcg gga tea gga aaa tcc acg 259 Arg Glu Gly He Leu Val Thr Gly Gly Ser Gly Ser Gly Lys Ser Thr 40 45 50 ctg att gat gcg ate acg gcg gta ttg ctt ccg ca gga aag ctg agg 307 Leu He Asp Ala He Thr Ala Val Leu Leu Pro Gln Gly Lys Leu Arg 55 60 65 ttt aac tet gcc gca cag gct aat act ccg cgg aat aag gga cgc agt 355 25 Phe Asn Be Wing Wing Gln Wing Asn Thr Pro Arg Asn Lys Gly Arg Ser 70 75 80 85 ttg gtt acc ate cgt ggc gct tgg cgt gcg ggg cag gag gat ccg ctg 403 Leu Val Thr Tyr He Arg Gly Wing Trp Arg Wing Gln Glu Asp Pro Leu 90 95 100 cag gat cag att gtc tcc acg tac cta cgt ccc cgc gca acc tat tcg 451 Gln Asp Gln He Val Ser Thr Tyr Leu Arg Pro Arg Wing Thr Tyr Ser 105 110 115 ctg gtt gt ttg act tat tcc aac ggt gaa ggc gtc gag falls acc ttg 499 Leu Val Gly Leu Thr Tyr Ser Asn Gly Glu Gly Val Glu His Thr Leu 120 125 130 gtg gct att ttc tat ctg aaa tcg gga falls aat tta acc tcc gat att 547 Val Ala He Phe Tyr Leu Lys Ser Gly His Asn Leu Thr Ser Asp He 135 140 145 tet tea tat tat ggt gtg ttt ccc gtt gat caa gac ate aat gcg ctg 595 Be Ser Tyr Tyr Gly Val Phe Pro Val Asp Gln Asp He Asn Ala Leu 150 155 160 165 ctg gat ttc ctg aaa gag ggc ate gat aaa cgc cag ate aga gct gct 643 Leu Asp Phe Leu Lys Glu Gly He Asp Lys Arg Gln He Arg Ala Wing 170 175 180 ttc aag gaa gcc ate ttt age gag cag cat tet gta ttc tcc ggc agg 691 Phe Lys Glu Wing He Phe Ser Glu Gln His Ser Val Phe Ser Gly Arg 185 190 195 ttt aga age cgt ttg ggg ate tcc agt gag gaa gct ttg ctg ttg ttg 739 Phe Arg Being Arg Leu Gly He Being Ser Glu Glu Wing Leu Leu Leu Leu 200 205 210 falling cgc gcg cag tcg gcg aaa gat ctt caa age ttg gat gatta ttt 787 His Arg Ala Gln Ser Ala Lys Asp Leu Gln Ser Leu Asp Asp Leu Phe 215 220 225 cgg gat tac atg ctg gtg gaa ccg gat acg ttc age att gcc aaa act 835 Arg Asp Tyr Met Leu Val Glu Pro Asp Thr Phe Ser He Ala Lys Thr 230 235 240 245 gcc gtg gaa cat ttc caa gac ctt gaa ggt gct tat gag cag gtc gaa 883 Wing Val Glu Gln Phe Gln Asp Leu Glu Gly Wing Tyr Glu Gln Val Glu 250 255 260 gat att aaa cgg cag ate falls acc ctg gat ect ttg gtg cag ctg aag 931 Asp He Lys Arg Gln He His Thr Leu Asp Pro Leu Val Gln Leu Lys 265 270 275 aat cgg cga gag aaa gcg caà cag tcc aaa gat cat gcc aat gca ctg 979 Asn Arg Arg Glu Lys Wing Gln Gln Ser Lys Asp His Wing Asn Wing Leu 280 285 290 aag aag gcg ctg ccg act gtc ggg aat cgc att aag aag ga ga ga ca ca 1027 Lys Lys Wing Leu Pro Thr Val Gly Asn Arg He Lys Lys Glu Glu Gln 295 300 305 gaa ccg ctg gtt cga ca g tc gtc gag ca g ac g cag cga agt cga 1075 Glu Pro Leu Val Arg Gln Phe Thr Val Glu Gln Thr Gln Arg Ser Arg 310 315 320 325 agg tgg agt ccg cca aaa ttg aga cag ate gtg ccc gcg aaa 1117 Arg Trp Ser Pro Pro Lys Leu Arg Gln He Val Pro Ala Lys 330 335 tgaaaaccct cgcgcacga? C aac 1140 < 210 > 292 < 211 > 339 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 292 Val Thr Ser Glu Gln Ala Leu Asp Pro He His Pro Gly Gln Phe Arg 1 5 10 15 Leu Ser Arg He Gln Leu He Asn Trp Gly Thr Phe His Gly Thr Val 20 25 30 Asp He Pro Val Thr Arg Glu Gly He Leu Val Thr Gly Gly Ser Gly 35 40 45 Ser Gly Lys Ser Thr Leu He Asp Wing He Thr Wing Val Leu Leu Pro 50 55 60 Gln Gly Lys Leu Arg Phe Asn Wing Wing Gln Wing Asn Thr Pro Arg 65 70 75 80 Asn Lys Gly Arg Ser Leu Val Thr Tyr He Arg Gly Wing Trp Arg Wing 85 90 95 Gln Glu Asp Pro Leu Gln Asp Gln He Val Ser Thr Tyr Leu Arg Pro 100 105 110 Arg Wing Thr Tyr Ser Leu Val Gly Leu Thr Tyr Ser Asn Gly Glu Gly 115 120 125 Val Glu His Thr Leu Val Wing He Phe Tyr Leu Lys Ser Gly His Asn 130 135 140 Leu Thr Ser Asp He Ser Ser Tyr Tyr Gly Val Phe Pro Val Asp Gln 145 150 155 160 Asp He Asn Ala Leu Leu Asp Phe Leu Lys Glu Gly He Asp Lys Arg 165 170 175 Gln He Arg Wing Wing Phe Lys Glu Wing He Phe Ser Glu Gln His Ser 180 185 190 Val Phe Ser Gly Arg Phe Arg Ser Arg Leu Gly He Ser Ser Glu Glu 195 200 205 Wing Leu Leu Leu Leu His Arg Wing Gln Being Wing Lys Asp Leu Gln Ser 210 215 220 Leu Asp Asp Leu Phe Arg Asp Tyr Met Leu Val Glu Pro Asp Thr Phe 225 230 235 240 Ser He Ala Lys Thr Ala Val Glu Gln Phe Gln Asp Leu Glu Gly Wing 245 250 255 Tyr Glu Gln Val Glu Asp He Lys Arg Gln He His Thr Leu Asp Pro 260 265 270 Leu Val Gln Leu Lys Asn Arg Arg Glu Lys Wing Gln Gln Ser Lys Asp 275 280 285 His Wing Asn Wing Leu Lys Lys Wing Leu Pro Thr Val Gly Asn Arg He 290 295 300 Lys Lys Glu Glu Gln Glu Pro Leu Val Arg Gln Phe Thr Val Glu Gln 305 310 315 320 Thr Gln Arg Ser Arg Arg Trp Ser Pro Pro Lys Leu Arg Gln He Val 325 330 335 Pro Ala Lys <; 210 > 293 < 211 > 1027 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1027) < 223 > FRXA00243 < 400 > 293 cactgcgcca gatttttgat gccgacactg tggeaggtgt gcgcgctgag tacgaaaaat 60 ttaacaaagc agcccatgat ggaaatgaag aggaacagaa gtg acc age gaa caa 115 ,.,.TO* ... ..,.".....-. . . «_..___.,« .. * _. i.

Val Thr Ser Glu Gln 1 5 gct tta gat ect ate drops cca ggt cag ttc cgt ctt tet cgg att cag 163 Wing Leu Asp Pro He His Pro Gly Gln Phe Arg Leu Ser Arg He Gln 10 15 20 ttg ate aac tgg gga acc ttc falls gga acg gtg gac att ect gtg acc 211 Leu He Asn Trp Gly Thr Phe His Gly Thr Val Asp He Pro Val Thr 25 30 35 agg gaa gga ate tta gtt acc ggt ggt tcg gga tea gga aaa tcc acg 259 • Arg Glu Gly He Leu Val Thr Gly Gly Ser Gly Ser Gly Lys Ser Thr 40 45 50 ctg att gat gcg ate acg gcg gta ttg ctt ccg ca gga aag ctg agg 307 Leu He Asp Ala He Thr Ala Val Leu Leu Pro Gln Gly Lys Leu Arg 55 60 65 ttt aac tet gcc gca cag gct aat act ccg cgg aat aag gga cgc agt 355 Phe Asn Be Ala Ala Gln Ala Asn Thr Pro Arg Asn Lys Gly Arg Ser 70 75 80 85 ttg gtt acc tat ate cgt ggc gct tgg cgt gcg cag gag gat ccg ctg 403 Leu Val Thr Tyr He Arg Gly Wing Trp Arg Wing Gln Glu Asp Pro Leu 90 95 100 10 cag gat cag att gtc tcc acg tac cta cgt ccc cgc gca acc tat tcg 451 Gln Asp Gln He Val Ser Thr Tyr Leu Arg Pro Arg Wing Thr Tyr Ser 105 110 115 ctg gtt gt ttg act tat tcc aac ggt gaa ggc gtc gag falls acc ttg 499 • Leu Val Gly Leu Thr Tyr Ser Asn Gly Glu Gly Val Glu His Thr Leu 120 125 130 gtg gct att ttc tat ctg aaa tcg gga cae aat tta acc tcc gat att 547 Val Ala He Phe Tyr Leu Lys Ser Gly His Asn Leu Thr Ser Asp He 135 140 145 tet tea tat tat ggt gtg ttt ccc gtt gat caa gac ate aat gcg ctg 595 Be Ser Tyr Tyr Gly Val Phe Pro Val Asp Gln Asp He Asn Ala Leu 150 155 160 165 15 ctg gat ttc ctg aaa gag ggc ate gat aaa cgc cag ate aga gct gct 643 Leu Asp Phe Leu Lys Glu Gly He Asp Lys Arg Gln He Arg Ala Wing 170 175 180 ttc aag gaa gcc ate ttt age gag cag cat tet gta ttc tcc ggc agg 691 Phe Lys Glu Wing He Phe Ser Glu Gln His Ser Val Phe Ser Gly Arg 185 190 195 ttt aga age cgt ttg ggg ate tcc agt gag gaa gct ttg ctg ttg ttg 739 Phe Arg Ser Arg Leu Gly He Ser Ser Glu Glu Ala Leu Leu Leu Leu • 200 205 210 falls cgc gcg cag tcg gcg aaa gat ctt caa age ttg gat gatta ttt 787 His Arg Ala Gln Ser Ala Lys Asp Leu Gln Ser Leu Asp Asp Leu Phe 215 220 225 20 cgg gat tac atg ctg gtg gaa ccg gat acg ttc age att gcc aaa act 835 Arg Asp Tyr Met Leu Val Glu Pro Asp Thr Phe Ser Wing Lys Thr 230 235 240 245 gcc gtg gaa ca t tc ca gac ctt gaa ggt gct tat gag cag gtc gaa Wing Val Glu Gln Phe Gln Asp Leu Glu Gly Wing Tyr Glu Gln Val Glu 250 255 260 gat att aaa cgg cag ate drops acc ctg gat ect ttg gtg cag ctg aag 931 Asp He Lys Arg Gln He His Thr Leu Asp Pro Leu Val Gln Leu Lys 265 270 275 aat cgg cga gag aaa gcg caa cag tcc aaa gat cat gcc aat gca ctg 979 Asn Arg Arg Glu Lys Ala Gln Gln Ser Lys Asp His Wing Asn Ala Leu 280 285 290 25 aag aag gcg ctg ccg act gtc ggg aat cgc att aag aag gaa gag caa 1027 -4Í-.á, Lys Lys Ala Leu Pro Thr Val Gly Asn Arg He Lys Lys Glu Glu Gln 295 300 305 < 210 > 294 < 211 > 309 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 294 Val Thr Ser Glu Gln Ala Leu Asp Pro He His Pro Gly Gln Phe Arg 1 5 10 15 Leu Ser Arg He Gln Leu He Asn Trp Gly Thr Phe His Gly Thr Val 20 25 30 Asp He Pro Val Thr Arg Glu Gly He Leu Val Thr Gly Gly Ser Gly 35 40 45 Ser Gly Lys Ser Thr Leu He Asp Wing He Thr Wing Val Leu Leu Pro 50 55 60 Gln Gly Lys Leu Arg Phe Asn Be Wing Wing Gln Wing Asn Thr Pro Arg 65 70 75 80 Asn Lys Gly Arg Ser Leu Val Thr Tyr He Arg Gly Wing Trp Arg Wing 85 90 95 Gln Glu Asp Pro Leu Gln Asp Gln He Val Ser Thr Tyr Leu Arg Pro 100 105 110 Arg Wing Thr Tyr Ser Leu Val Gly Leu Thr Tyr Ser Asn Gly Glu Gly 115 120 125 Val Glu His Thr Leu Val Wing He Phe Tyr Leu Lys Ser Gly His Asn 130 135 140 Leu Thr Ser Asp Be Ser Tyr Tyr Gly Val Phe Pro Val Asp Gln 145 150 155 160 Asp He Asn Wing Leu Leu Asp Phe Leu Lys Glu Gly He Asp Lys Arg 165 170 175 Gln He Arg Wing Wing Phe Lys Glu Wing He Phe Ser Glu Gln His Ser 180 185 190 Val Phe Ser Gly Arg Phe Arg Ser Arg Leu Gly He Ser Ser Glu Glu . 195 200 205 Ala Leu Leu Leu Leu His Arg Ala Gln Ser Ala Lys Asp Leu Gln Ser 210 215 220 Leu Asp Asp Leu Phe Arg Asp Tyr Met Leu Val Glu Pro Asp Thr Phe 225 230 235 240 Be He Wing Lys Thr Wing Val Glu Gln Phe Gln Asp Leu Glu Gly Wing 245 250 255 Tyr Glu Gln Val Glu Asp He Lys Arg Gln He His Thr Leu Asp Pro 260 265 270 Leu Val Gln Leu Lys Asn Arg Arg Glu Lys Ala Gln Gln Ser Lys Asp 275 280 285 His Wing Asn Wing Leu Lys Lys Wing Leu Pro Thr Val Gly Asn Arg He 290 295 300 Lys Lys Glu Glu Gln 305 < 210 > 295 < 211 > 2325 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (2302) < 223 > RXA00259 < 400 > 295 ggcctta-tta, acat, acggicg gttct, ageac acageg, atgg atgatgtgtc, ccaccgatat 60 tgctgcatgt igcca, agattt agcacggtac agtget, agaa atg age gga ctg ttt 115 Met Ser Gly Leu Phe 1 5 • acc cca ttt tea gat gcg gca aaa aac aac acg gta aaa act gat gga 163 Thr Pro Phe Ser Asp Wing Wing Lys Asn Asn Thr Val Lys Thr Asp Gly 10 15 20 gat tea gta tet ggt cga gac ttg ect att act aag ate tet gag gat 211 Asp Ser Val Ser Gly Arg Asp Leu Pro He Thr Lys He Ser Glu Asp 25 30 35 cgt ttc gag cgt tet gcg tat tea gcc cag ctg gca aat ata ate tgc 259 Arg Phe Glu Arg Ser Ala Tyr Ser Ala Gln Leu Ala Asn He He Cys 40 45 50 gat gtg gca ect tgg gga gcg age act gtt ttc agt ctt act ggt cag 307 Asp Val Wing Pro Trp Gly Wing Ser Thr Val Phe Ser Leu Thr Gly Gln 55 60 65 10 tgg ggc agt ggt aag here tet ctt gtt aat ttg att cgc tcg gaa gaa 355 Trp Gly Ser Gly Lys Thr Ser Leu Val Asn Leu He Arg Ser Glu Glu 70 75 80 85 tet cta tcg aac gaa aaa • tgg here ate gtt gat ttc aac ccg tgg gtg 403 Ser Leu Ser Asn Glu Lys Trp Thr He Val Asp Phe Asn Pro Trp Val 90 95 100 gcc tet gac ccg caat tet ttg att gag gag ttt tac cga gta ate gtt 451 Wing Ser Asp Pro Gln Ser Leu He Glu Glu Phe Tyr Arg Val He Val 105 110 115 ggg acg gta ect gat gat aag acc ggc caa aag ate aaa act gtt ctg 499 Gly Thr Val Pro Asp Asp Lys Thr Gly Gln Lys He Lys Thr Val Leu 120 125 130 15 cag aaa acc ttt age acg att ggg tea att gca ggt ggg gtc gga ggg 547 Gln Lys Thr Phe Ser Thr He Gly Ser He Wing Gly Gly Val Gly Gly 135 140 145 ttt ggt gtc cta gaa gca ctt gcg etc tea aaa gga gta gta gat gca 595 Phe Gly Val Leu Glu Ala Leu Ala Leu Ser Lys Gly Val Asp Wing Ala 150 155 160 165 aac gct tat aag here tgg aaa cag gag ca gt gat tcg tgg cca acg 643 Asn Ala Val Tyr Lys Thr Trp Lys Gln Glu Gln Asp Ser Trp Pro Thr • 170 175 180 ctg tat here cgt gct gcg aac cat ttt aaa gat ctg aac aga cga att 691 Leu Tyr Thr Arg Wing Wing Asn His Phe Lys Asp Leu Asn Lys Arg He 185 190 195 20 etc att gtc gtc gat gat gat gat cgc etc cat act ga t gag ttg gcg 739 Leu He Val Val Asp Asp He Asp Arg Leu His Thr Asp Glu Leu Wing 200 205 210 ctg tta atg aaa gta ata cgc ttg ctt gga cga ttc ccg cag gtg aat 787 Leu Leu Met Lys Val He Arg Leu Leu Gly Arg Phe Pro Gln Val Asn 215 220 225 tat ctt ttg gtt tat gaa gaa gaa tea ctg tta acg acg cta gcc aga 835 Tyr Leu Leu Val Tyr Glu Glu Glu Ser Leu Leu Thr Thr Leu Ala Arg 230 235 240 245 tcg here gct gta ggt ggt ggt age gag gat gat gct tgc tgc tgc atg gag 883 Ser Thr Wing Val Gly Gly Ser Glu Asp Asp Ala Leu Arg Phe Met Glu 250 255 260 25 aaa ate gtg cag tat ect ttc gat gtt ccg ect ctg here tea ttt ca 931 Lys He Val Gln Tyr Pro Phe Asp Val Pro Pro Leu Thr Ser Phe Gln 265 270 275 ata gag aaa gag etc agt gca tta ttt gac aag ctt ttc cag ggt gtt 979 He Glu Lys Glu Leu Ser Ala Leu Phe Asp Lys Leu Phe Gln Gly Val 280 285 290 tcg cta tcg ggt gat ect gaa gac ttt gca cta gtg aag tcg aga atg 1027 Ser Leu Ser Gly Asp Pro Glu Asp Phe Ala Leu Val Lys Ser Arg Met 295 300 305 ttc gat gtc tgg gaa aag act ctg gtc acg ccg agg ctg ttg falls cgt 1075 • Phe Asp Val Trp Glu Lys Thr Leu Val Thr Pro Arg Leu Leu His Arg 310 315 320 325 ttt gct gct cta cta acc aac tgg act cgg ata tat gga tea ggt gaa 1123 Phe Ala Ala Leu Leu Thr Asn Trp Thr Arg He Tyr Gly Ser Gly Glu 330 335 340 gtt aac ggc gtt gat etc here ata ctt gcg acc att cga att gtt ttt 1171 Val Asn Gly Val Asp Leu Thr He Leu Wing Thr He Arg He Val Phe 345 350 355 ccg tet gtg tat aaa cgt ctt tet cga gcg aag gaa gta ttg ctt caa 1219 Pro Ser Val Tyr Lys Arg Leu Ser Arg Ala Lys Glu Val Leu Leu Gln 360 365 370 10 gga ggt cga acg here ggc tcg cag aaa ccc ggt tgg gaa aag caa tta 1267 Gly Gly Arg Thr Thr Gly Ser Gln Lys Pro Gly Trp Glu Lys Gln Leu 375 380 385 tgt gag ggg atg aac aac gag cag atg gat ctt tta aag acc atg ctt 1315 • Cys Glu Gly Met Asn Asn Glu Gln Met Asp Leu Leu Lys Thr Met Leu 390 395 400 405 ttc ttc ctt ttc cca cgt ctt tcg gat cae ect agt acg aga aattgg ccaatt 1363 Leu Phe Leu Phe Pro Arg Leu Ser Asp His Pro Ser Thr Arg Met His 410 415 420 cgt gag agg ggg ate tcg acg gaa gtt tat ttt gac acg tac eettcc aattgg 1411 Arg Glu Arg Gly He Ser Thr Glu Val Tyr Phe Asp Thr Tyr L Leeuu Met 425 430 435 15 ttt caá aga ect gga cat gtc ata agt gat gaa cag ttg gat aag tat 1459 Phe Gln Arg Pro Gly His Val He Ser Asp Glu Gln Leu Asp Lys Tyr 440 445 450 cta tet aat gcg gac gat gct atg ggt ttc gtc gat tta att aac tcc 1507 Leu Ser Asn Wing Asp Asp Wing Met Gly Phe Val Asp Leu He Asn Ser 455 460 465 gat gac aat gac atg gtg gca tea gtg atg aaa aag ctt ect cta gca 1555 Asp Asp Asn Asp Met Val Wing Ser Val Met Lys Lys Leu Pro Leu Ala 470 475 480 485 • att gat cga gat gga gag ggt gtt agg falls atg gca gtt gag gtg 1603 He Asp Arg Leu Asp Gly Glu Gly Val Arg His Met Wing Val Glu Val 490 495 500 20 tta ttc acc gct gct gat aat ggt atg cat gat aaa ggt cgt ca gtg cgt 1651 Leu Phe Thr Wing Wing Asn Gly Met His Asp Lys Gly Arg Gln Val Arg 505 510 515 atg age ggc ata ttc agt gac ctg tat tcc cat gcg tgc tcg att ctt 1699 Met Ser Gly He Phe Ser Asp Leu Tyr Ser His Wing Cys Ser He Leu 520 525 530 ggt gca ttg ect cata tta cca gtg gaa caa etc tat gag aaa ttc ttt 1747 Gly Ala Leu Pro Gln Leu Pro Val Glu Gln Leu Tyr Glu Lys Phe Phe 535 540 545 tet gag atg acg ctt aat gag gct gct ttc tgg tta aac cag gtg ggg 1795 Ser Glu Met Thr Leu Asn Glu Ala Wing Phe Trp Leu Asn Gln Val Gly 550 555 560 565 25 gaa agg gct aga gcc tgt ggt aat gat gta agt ggc ctt gag ctt ttt 1843 Glu Arg Wing Arg Wing Cys Gly Asn Asp Val Ser Gly Leu Glu Leu Phe 570 575 580 cgt aaa gtt aat ata aag acc gaa gct aga att tta agt gta ttg aag 1891 Arg Lys Val Asn He Lys Thr Glu Wing Arg He Leu Ser Val Leu Lys 585 590 595 aat cag gac ccc tea gat tgg gat tta ggt cca tat tcg ctt ggt att 1939 Asn Gln Asp Pro Ser Asp Trp Asp Leu Gly Pro Tyr Ser Leu Gly He 600 605 610 ttg gcg aaa age tcg aat ttt tet tea gtg ctg aag tet ctg caa agt 1987 • Leu Ala Lys Ser Ser Asn Phe Ser Ser Val Leu Lys Ser Leu Gln Ser 615 620 625 ggt ata gag gaa cat cag ttt gat gtg ata gat gga att gtg ctt ttc 2035 Gly He Glu Glu His Gln Phe Asp Val He Asp He Gly Val Leu Phe 630 635 640 645 tta acg act gtg tat tet tcg cga cag gga cca age ggt ggt gca tgg 2083 Leu Thr Thr Val Tyr Ser Ser Arg Gln Gly Pro Ser Gly Gly Wing Trp 650 655 660 ata gat tet ttt cag cat agt ctg ttt tea cgg tac gta ect gat tet 2131 He Asp Ser Phe Gln His Ser Leu Phe Ser Arg Tyr Val Pro Asp Ser 665 670 675 10 cta cgg gct ata acc aag tet gaa gta gat gta gaa cta ggt aag ata 2179 Leu Arg Ala He Thr Lys Ser Glu Val Asp Val Glu Leu Gly Lys He 680 685 690 w cag ttc acg gat ttt age tgg gaa ggg aag cga aaa gtt gtc gca tat 2227 Gln Phe Thr Asp Phe Ser Trp Glu Gly Lys Arg Lys Val Val Ala Tyr 695 700 705 gca ctg gag act gga aga agt gat ttc act cga gaga cga tta ggg ggc 2275 Wing Leu Glu Thr Gly Arg Ser Asp Phe Thr Arg Glu Arg Leu Gly Gly 710 715 720 725 tac agt ate gca gat tet a ta gtc gat tgatgaggct gaggtcatga 2322 Tyr Ser He Wing Asp Ser He Val Asp 730 15 ctt 2325 < 210 > 296 < 211 > 734 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 296 Met Ser Gly Leu Phe Thr Pro Phe Ser Asp Wing Wing Lys Asn Asn Thr • 1 5 10 15 Val Lys Thr Asp Gly Asp Ser Val Ser Gly Arg Asp Leu Pro He Thr 20 25 30 20 Lys He Ser Glu Asp Arg Phe Glu Arg Ser Ala Tyr Ser Ala Gln Leu 35 40 45 Wing Asn He He Cys Asp Val Wing Pro Trp Gly Wing Ser Thr Val Phe 50 55 60 Ser Leu Thr Gly Gln Trp Gly Ser Gly Lys Thr Ser Leu Val Asn Leu 65 70 75 80 He Arg Ser Glu Glu Ser Leu Ser Asn Glu Lys Trp Thr He Val Asp 85 90 95 Phe Asn Pro Trp Val Wing Ser Asp Pro Gln Ser Leu He Glu Glu Phe 100 105 110 Tyr Arg Val He Val Gly Thr Val Pro Asp Asp Lys Thr Gly Gln Lys 115 120 125 25 He Lys Thr Val Leu Gln Lys Thr Phe Ser Thr He Gly Ser He Wing 130 135 140 Gly Gly Val Gly Gly Phe Gly Val Leu Glu Ala Leu Ala Leu Ser Lys 145 150 155 160 Gly Val Asp Ala Ala Asn Ala Val Tyr Lys Thr Trp Lys Gln Glu Gln 165 170 175 Asp Ser Trp Pro Thr Leu Tyr Thr Arg Ala Ala Asn His Phe Lys Asp 180 185 190 Leu Asn Lys Arg He Leu He Val Val Asp Asp He Asp Arg Leu His 195 200 205 • Thr Asp Glu Leu Ala Leu Leu Met Lys Val He Arg Leu Leu Gly Arg 210 215 220 Phe Pro Gln Val Asn Tyr Leu Leu Val Tyr Glu Glu Glu Be Leu Leu 225 230 235 240 Thr Thr Leu Wing Arg Ser Thr Wing Val Gly Gly Ser Glu Asp Asp Wing 245 250 255 Leu Arg Phe Met Glu Lys He Val Gln Tyr Pro Phe Asp Val Pro Pro 260 265 270 Leu Thr Ser Phe Gln He Glu Lys Glu Leu Ser Ala Leu Phe Asp Lys 275 280 285 Leu Phe Gln Gly Val Ser Leu Ser Gly Asp Pro Glu Asp Phe Ala Leu 10 290 295 300 Val Lys Ser Arg Met Phe Asp Val Trp Glu Lys Thr Leu Val Thr Pro 305 310 315 320 Arg Leu Leu His Arg Phe Ala Ala Leu Leu Thr Asn Trp Thr Arg He • 325 330 335 Tyr Gly Ser Gly Glu Val Asn Gly Val Asp Leu Thr He Leu Wing Thr 340 345 350 He Arg He Val Phe Pro Ser Val Tyr Lys Arg Leu Ser Arg Ala Lys 355 360 365 Glu Val Leu Leu Gln Gly Gly Arg Thr Thr Gly Ser Gln Lys Pro Gly 370 375 380 Trp Glu Lys Gln Leu Cys Glu Gly Met Asn Asn Glu Gln Met Asp Leu 15 385 390 395 400 Leu Lys Thr Met Leu Leu Phe Leu Phe Pro Arg Leu Ser Asp His Pro 405 410 415 Ser Thr Arg Met His Arg Glu Arg Gly He Ser Thr Glu Val Tyr Phe 420 425 430 Asp Thr Tyr Leu Met Phe Gln Arg Pro Gly His Val He Ser Asp Glu 435 440 445 Gln Leu Asp Lys Tyr Leu Ser Asn Wing Asp Asp Wing Met Gly Phe Val 450 455 460 • Asp Leu He Asn Ser Asp Asp Asn Asp Met Val Wing Ser Val Met Lys 465 470 475 480 Lys Leu Pro Leu Wing He Asp Arg Leu Asp Gly Glu Gly Val Arg His 20 485 490 495 Met Wing Val Glu Val Leu Phe Thr Wing Wing Asn Gly Met His Asp Lys 500 505 510 Gly Arg Gln Val Arg Met Ser Gly He Phe Ser Asp Leu Tyr Ser His 515 520 525 Ala Cys Ser He Leu Gly Ala Leu Pro Gln Leu Pro Val Glu Gln Leu 530 535 540 Tyr Glu Lys Phe Phe Ser Glu Met Thr Leu Asn Glu Ala Wing Phe Trp 545 550 555 560 Leu Asn Gln Val Gly Glu Arg Ala Arg Ala Cys Gly Asn Asp Val Ser 565 570 575 Gly Leu Glu Leu Phe Arg Lys Val Asn He Lys Thr Glu Wing Arg He 25 580 585 590 Leu Ser Val Leu Lys Asn Gln Asp Pro Ser Asp Trp Asp Leu Gly Pro 595 600 605 Tyr Ser Leu Gly He Leu Wing Lys Ser Ser Asn Phe Ser Ser Val Leu 610 615 620 Lys Ser Leu Gln Ser Gly He Glu Glu His Gln Phe Asp Val He Asp 625 630 635 640 He Gly Val Leu Phe Leu Thr Thr Val Tyr Ser Ser Arg Gln Gly Pro 645 650 655 Ser Gly Gly Wing Trp He Asp Ser Phe Gln His Ser Leu Phe Ser Arg 660 665 670 Tyr Val Pro Asp Ser Leu Arg Wing He Thr Lys Ser Glu Val Asp Val 675 680 685 Glu Leu Gly Lys He Gln Phe Thr Asp Phe Ser Trp Glu Gly Lys Arg 690 695 700 Lys Val Val Ala Tyr Ala Leu Glu Thr Gly Arg Ser Asp Phe Thr Arg 705 710 715 720 Glu Arg Leu Gly Gly Tyr Ser He Wing Asp Ser He Val Asp 725 730 < 210 > 297 10 < 211 > 789 < 212 > DNA < 213 > Corynebact: erium gl .utamicum • < 220 > < 221 > CDS < 222 > (101) .. (766) < 223 > RXN00410 < 400 > 297 gtgttgatge < gttagtccac ccacgcagct acgccccaaa gga; ataatct tgaaccctgc 60 cacagat; aac igctccgccgg tcctttcagc ccaagatctc atg atg ate tat gga 115 15 Met Met He Tyr Gly 1 5 aaa gga tea here gaa gtt cgg gct etc gat ggc att tet gta cag att 163 Lys Gly Ser Thr Glu Val Arg Ala Leu Asp Gly He Ser Val Gln He 10 15 20 cag tcc gac aaa tgg acc tcc ate atg ggg ca g tea ggc tet ggc aaa 211 Gln Ser Asp Lys Trp Thr Ser He Met Gly Gln Ser Gly Ser Gly Lys 25 30 35 here act ctg cag tgc ctt tcc gga ttg gcg cag cca acc tea ggc 259 • Thr Thu Leu Leu Gln Cys Leu Ser Gly Leu Wing Gln Pro Thr Ser Gly 40 45 50 aga gtg here ctg aac aac aac aac t a c t a c tg age tcc ctg tea gaa 307 20 Arg Val Thr Leu Asn Lys Asn Asn He Thr Leu Ser Ser Leu Ser Glu 55 60 65 aat aag cgt gcc aag ctg cgc cgc acg falls age atg gtg ttt cag 355 Asn Lys Arg Ala Lys Leu Arg Arg Thr His He Ser Met Val Phe Gln 70 75 80 85 gat ttc aac ttg gtg ect att ttg tcg gtg aag gac aat att ttg ctg 403 Asp Phe Asn Leu Val Pro He Leu Ser Val Lys Asp Asn He Leu Leu 90 95 100 ccg ttg cgt ctt gcg cat cgc agg gtg gat aag cag tgg ttt gaa cae 451 Pro Leu Arg Leu Ala His Arg Arg Val Asp Lys Gln Trp Phe Glu His 105 110 115 ate acc agt gtg ttg aag att gat aat cgt atg cgc cat ttg ect ggg 499 25 He Thr Ser Val Leu Lys He Asp Asn Arg Met Arg His Leu Pro Gly * * - '*' 120 125 130 gag ctg tet ggc ggt cag ca g ca gc gcc gcg att gcc cgg gcg ttg 547 Glu Leu Ser Gly Gln Gln Gln Arg Ala Wing Ala Wing Arg Ala Leu 135 140 145 atg tet agg ccc gat att gtc att gcg gat gag cca here gga agt ttg 595 Met Ser Arg Pro Asp He Val He Wing Asp Glu Pro Thr Gly Ser Leu 150 155 160 165 gat tcc gtc acc age gat gca gtg ttg aat ttg ttc cgc age att gtt 643 • Asp Ser Val Thr Ser Asp Wing Val Leu Asn Leu Phe Arg Ser He Val 170 175 180 gat gat ttt ggg cag tea ctt gtg ttt gtc acc fall gat aaa gat gct 691 Asp Asp Phe Gly Gln Ser Leu Val Phe Val Thr His Asp Lys Asp Wing 185 190 195 gct falls cgt ggt gac gtg ttg ate here atg cgt gat ggc aag ate ate 739 Wing His Arg Gly Asp Val Leu He Thr Met Arg Asp Gly Lys He He 200 205 210 gat acg gca gat ttg cgg gtg ggg cgt taatgttcag gcttgctttc 786 Asp Thr Wing Asp Leu Arg Val Gly Arg 215 220 gct 789 10 < 210 > 298 < 211 > 222 • < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 298 Met Met He Tyr Gly Lys Gly Ser Thr Glu Val Arg Ala Leu Asp Gly 1 5 10 15 He Ser Val Gln He Gln Ser Asp Lys Trp Thr Ser Met Met Gly Gln 20 25 30 Ser Gly Ser Gly Lys Thr Thr Leu Leu Gln Cys Leu Ser Gly Leu Wing 15 35 40 45 Gln Pro Thr Ser Gly Arg Val Thr Leu Asn Lys Asn Asn He Thr Leu 50 55 60 Ser Ser Leu Ser Glu Asn Lys Arg Ala Lys Leu Arg Arg Thr His He 65 70 75 80 Ser Met Val Phe Gln Asp Phe Asn Leu Val Pro He Leu Ser Val Lys 85 90 95 Asp Asn He Leu Leu Pro Leu Arg Leu Wing His Arg Arg Val Asp Lys • 100 105 110 Gln Trp Phe Glu His He Thr Ser Val Leu Lys He Asp Asn Arg Met 115 120 125 Arg His Leu Pro Gly Glu Leu Ser Gly Gln Gln Gln Gln Arg Wing Ala 20 130 135 140 He Ala Arg Ala Leu Met Ser Arg Pro Asp He Val He Wing Asp Glu 145 150 155 160 Pro Thr Gly Ser Leu Asp Ser Val Thr Ser Asp Wing Val Leu Asn Leu 165 170 175 Phe Arg Ser He Val Asp Asp Phe Gly Gln Ser Leu Val Phe Val Thr 180 185 190 His Asp Lys Asp Ala Ala His Arg Gly Asp Val Leu He Thr Met Arg 195 200 2 05 Asp Gly Lys He He Asp Thr Wing Asp Leu Arg Val Gly Arg 210 215 220 25 < 210 > 299 üwi ^ ri ^ liáliÉ ^ < 211 > 789 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (766) < 223 > FRXA00410 < 400 > 299 gtgttgatge gttagtccac ccacgcagct acgccccaaa ggaataatct tgaaccctgc 60 cacagataac gctccgccgg tcctttcagc ccaagatctc atg atg ate tat gga 115 Met Met He Tyr Gly 1 5 aaa gga tea here gaa gtt cgg gct etc gat ggc att tet gta cag att 163 Lys Gly Ser Thr Glu Val Arg Ala Leu Asp Gly He Ser Val Gln He 10 15 20 cag tcc gac aaa tgg acc atcc ggg ca g tea ggc tet ggc aaa 211 Gln Ser Asp Lys Trp Thr Ser He Met Gly Gln Ser Gly Ser Gly Lys 25 30 35 here act ctg ttg cag tgc ctt tcc gga ttg gcg cag cca acc tea ggc 259 Thr Thr Leu Leu Gln Cys Leu Ser Gly Leu Wing Gln Pro Thr Ser Gly 40 45 50 aga gtg here ctg aac aaa aac aac ate ac t tg age tcc ctg tea gaa 307 Arg Val Thr Leu Asn Lys Asn Asn He Thr Leu Ser Ser Leu Ser Glu 55 60 65 aat aag cgt gcc aag ctg cgt cgc acg falls ate age atg gtg ttt cag 355 Asn Lys Arg Ala Lys Leu Arg Arg Thr His He Ser Met Val Phe Gln 70 75 80 85 gat ttc aac ttg gtg ect att ttg tcg gtg aag gac aat att ttg ctg 403 Asp Phe Asn Leu Val Pro He Leu Ser Val Lys Asp Asn He Leu Leu 90 95 100 ccg ttg cgt ctt gcg cat cgc agg gtg gat aag cag tgg ttt gaa falls 451 Pro Leu Arg Leu Ala His Arg Arg Val Asp Lys Gln Trp Phe Glu His 105 110 115 ate acc agt gtg ttg aag att gat aat cgt atg cgc cat ttg ect ggg 499 He Thr Ser Val Leu Lys He Asp Asn Arg Met Arg His Leu Pro Gly 120 125 130 gag ctg tet ggc ggt cag ca g ca gcg gcg att gcc cgg gc g tg 547 Glu Leu Ser Gly Gly Gln Gln Gln Arg Wing Wing Wing Wing Arg Wing Leu 135 140 145 atg tet agg ccc gat att gtc att gcg gat gag cca here gga agt ttg 595 Met Ser Arg Pro Asp He Val He Wing Asp Glu Pro Thr Gly Ser Leu 150 155 160 165 gat tcc gtc action gca gtg gtg ttg aat ttg tcg cgc age att gtt 643 Asp Ser Val Thr Ser Asp Ala Val Leu Asn Leu Phe Arg Ser He Val 170 175 180 gat gat ttt ggg cag tea ctt gtt ttt gtc acc fall gat aaa gat gct 691 Asp Asp Phe Gly Gln Ser Leu Val Phe Val Thr His Asp Lys Asp Wing 185 190 195 gct falls cgt ggt gac gtg ttg ate here atg cgt gat ggc aag ate ate 739 Wing His Arg Gly Asp Val Leu He Thr Met Arg Asp Gly Lys He He 200 205 210 gat acg gca gat ttg cgg gtg ggg cgt taatgttcag gcttgctttc 786 Asp Thr Wing Asp Leu Arg Val Gly Arg 215 220 gct 789 «-.« .át.i.-i < 210 > 300 < 211 > 222 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 300 Met Met He Tyr Gly Lys Gly Ser Thr Glu Val Arg Ala Leu Asp Gly 1 5 10 15 He Ser Val Gln He Gln Ser Asp Lys Trp Thr Ser Met Met Gly Gln 20 25 30 Ser Gly Ser Gly Lys Thr Thr Leu Leu Gln Cys Leu Ser Gly Leu Wing 35 40 45 Gln Pro Thr Ser Gly Arg Val Thr Leu Asn Lys Asn Asn He Thr Leu 50 55 60 Ser Ser Leu Ser Glu Asn Lys Arg Ala Lys Leu Arg Arg Thr His He 65 70 75 80 Ser Met Val Phe Gln Asp Phe Asn Leu Val Pro He Leu Ser Val Lys 85 90 95 Asp Asn He Leu Leu Pro Leu Arg Leu Wing His Arg Arg Val Asp Lys 10 100 105 110 Gln Trp Phe Glu His He Thr Ser Val Leu Lys He Asp Asn Arg Met 115 120 125 Arg His Leu Pro Gly Glu Leu Ser Gly Gln Gln Gln Gln Arg Wing Ala • 130 135 140 He Ala Arg Ala Leu Met Ser Arg Pro Asp He Val He Wing Asp Glu 145 150 155 160 Pro Thr Gly Ser Leu Asp Ser Val Thr Ser Asp Wing Val Leu Asn Leu 165 170 175 Phe Arg Ser He Val Asp Asp Phe Gly Gln Ser Leu Val Phe Val Thr 180 185 190 His Asp Lys Asp Wing Wing His Arg Gly Asp Val Leu He Thr Met Arg 15 195 200 2 05 Asp Gly Lys He He Asp Thr Wing Asp Leu Arg Val Gly Arg 210 215 220 < 210 > 301 < 211 > 1500 < 212 > DNA < 213 > Corynebacterium glutamicum • < 220 > < 221 > CDS < 222 > (101) .. (1477) 20 < 223 > RXN00456 < 400 > 301 ctcaccaacc cggagatcgt cacagcggtg ctaacggatc atgectaget tatggcgtgc 60 tcgtcgcaga cttttgctca ttgccctagg tgtacttggt gtg ctg cag gca ctg 115 Val Leu Gln Ala Leu 1 5 ctg gcg ate atg gtg tcg ttg age gta gcc gcc ata ctt gag gga aac 163 Leu Ala He Met Val Ser Leu Ser Val Ala Ala He Leu Glu Gly Asn 10 15 20 cga gca ctt gtt gt gt ttg ctg ctt gct acc acg ttg ggt ttg ggg gtg 211 Arg Ala Leu Val Gly Leu Leu Leu Ala Thr Thu Leu Gly Leu Gly Val 25 25 30 35 4-?..? .1 A gcg cag tgg att caa aaa gta gca gaa gatta ggc cag cat tat 259 Wing Gln Trp He Gln Lys Val Val Wing Glu Asp Leu Gly Gln His Tyr 40 45 50 gtg cat gag gtg cgt cgt gaa ttg gtg ggt gct gcg ctg gtg ect gga 307 Val His Glu Val Arg Arg Glu Leu Val Gly Ala Ala Leu Val Pro Gly 55 60 65 aat acg gcc tcg ttg ggc gtg act gtc acc cga gcc age aat gat etc. 355 Asn Thr Ala Ser Leu Gly Val Thr Val Thr Arg Ala Ser Asn Asp Leu 70 75 80 85 • acc gcg gtg cgc aat tgg gtg gct ttg ggc att gtt ccg atg gtc acc 403 Thr Ala Val Arg Asn Trp Val Ala Leu Gly He Val Pro Met Val Thr 90 95 100 ggg ctg ccg ttg att gcg att gtg ctg gtg gcg ttg ttt ate ca cat gat 451 Gly Leu Pro Leu He Wing He Val Leu Val Wing Leu Phe He Gln Asp 105 110 115 etc cgc here ggc gtg gct gtt act gtg cca ctg etc atg tgt gta gcc 499 Leu Arg Thr Gly Val Wing Val Thr Val Pro Leu Leu Met Cys Val Wing 120 125 130 gtg ctg ccg gtg gtg gcg cgg tgg act ttg aaa aga gca cgt gaa cta 547 Val Leu Pro Val Val Ala Arg Trp Thr Leu Lys Arg Ala Arg Glu Leu 10 135 140 145 cgc aaa aaa cgt gga cgc atg gct gcg cgg ate gca gat tet gtc atg 595 Arg Lys Lys Arg Gly Arg Met Wing Wing Arg He Wing Asp Ser Val Met 150 155 160 165 • gct gga gata tta ctg drops gca here gga gca ata gac cgt gag etc aat 643 Wing Gly Glu Leu Leu His Wing Thr Gly Wing He Asp Arg Glu Leu Asn 170 175 180 gca gtc acc cga gat tcc gac cga gtg gtg ata gct gct gta aga cgt 691 Wing Val Thr Arg Asp Ser Asp Arg Val Val He Wing Wing Val Arg Arg 185 190 195 tcc tgg gcc acc ggt ttt age cgc gca ttg atg gcc atg gca gcc tcg 739 Ser Trp Wing Thr Gly Phe Ser Arg Ala Leu Met Ala Met Ala Ala Ser 15 200 205 210 ctt ggc act gtc age att gtg att tet ggc falls ctg gaa gta agt gag 787 Leu Gly Thr Val Ser He Val He Ser Gly H s Leu Glu Val Ser Glu 215 220 225 gtt gcg gga ata atg atg ctt ctt ggc gtt ctt gcc act cca gtt gca 835 Val Ala Gly Met Met Leu Leu Gly Val Leu Ala Thr Pro Val Ala 230 235 240 245 gaa ctt ggc cgc gtg gtg gaa tat cgc ca a tat tat aaa gcc gcg here 883 Glu Leu Gly Arg Val Val Glu Tyr Arg Gln Asn Tyr Lys Ala Wing Thr • 250 255 260 cgc ate ctg att cca ctt ctg caa cga ggc tea gaa ttt aaa falls tcc 931 Arg He Leu He Pro Leu Leu Gln Arg Gly Ser Glu Phe Lys His Ser 20 265 270 275 caá caa aaa cta ccc ggg ttg caa gca here gaa gga ate ccc ggt gtc 979 Gln Gln Lys Leu Pro Gly Leu Gln Ala Thr Glu Gly He Pro Gly Val 280 285 290 tat gtc aaa ggt att tcc gcc ctt ect gga gag cgg tac tac etc drops 1027 Tyr Val Lys Gly He Ser Wing Leu Pro Gly Glu Arg He Tyr Leu His 295 300 305 ggc tet gca gc gcg acg aga aga tgg gtc acc tcg ttg tet gca atg 1075 Gly Ser Wing Asp Wing Thr Arg Lys Trp Val Thr Ser Leu Ser Wing Met 310 315 320 325 gag gaa ggc here gat gta ata gtc aac ggt caa agg ctt tcg cag ctt 1123 Glu Glu Gly Thr Asp Val Hen Val Asn Gly Gln Arg Leu Ser Gln Leu 25 330 335 340 ect ttg aaa caa cga cgc gcc etc ate gga ate gcc tea gca cae falls 1171 Pro Leu Lys Gln Arg Arg Ala Leu He Gly He Ala Ser Ala His His 345 350 355 falls tta age cgt ggt tea gta tcg cgc ctg gtt ggt ttg cga gtg ccg 1219 His Leu Ser Arg Gly Ser Val Ser Arg Leu Val Gly Leu Arg Val Pro 360 365 370 gat gcc acc gtg gaa gaa att gag caca gca ctg gaa ca gtt ggt ctg 1267 Asp Ala Thr Val Glu Glu He Glu Gln Ala Leu Glu Gln Val Gly Leu 375 380 385 • aac aac ac ggg aaa caa cgc ttg aaa aac ggc gga falls ccc tgg agt 1315 Asn Asn Thr Gly Lys Gln Arg Leu Lys Asn Gly Gly His Pro Trp Ser 390 395 400 405 act tcg cag ate aac aaa ctg aaa att gcc age gcc acc ctt cga acc 1363 Thr Ser Gln He Asn Lys Leu Lys He Wing Being Wing Thr Leu Arg Thr 410 415 420 cca ccg ctt ttg gta ctt gaa ggc ate acc ect gaa aac etc etc aac 1411 Pro Pro Leu Leu Val Leu Glu Gly He Thr Pro Glu Asn Leu Leu Asn 425 430 435 tat ccc gga gtg ate ate tc c acc gtt cag gag aac cca tcc gaa here 1459 Tyr Pro Gly Val He He Ser Thr Val Gln Glu Asn Pro Ser Glu Thr 10 440 445 450 tgg cgg ca gtg aac ate taatctagaa acatggcagg acg 1500 Trp Arg Gln Val Asn He 455 • < 210 > 302 < 211 > 459 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 302 Val Leu Gln Ala Leu Leu Ala He Met Val Ser Leu Ser Val Ala Ala 15 1 5 10 15 He Leu Glu Gly Asn Arg Ala Leu Val Gly Leu Leu Leu Ala Thr Thr 20 25 30 Leu Gly Leu Gly Val Wing Gln Trp He Gln Lys Val Val Wing Glu Asp 35 40 45 Leu Gly Gln His Tyr Val His Glu Val Arg Arg Glu Leu Val Gly Wing 50 55 60 Wing Leu Val Pro Gly Asn Thr Wing Being Leu Gly Val Thr Val Thr Arg 65 70 75 80 • Wing Being Asn Asp Leu Thr Wing Val Arg Asn Trp Val Wing Leu Gly He 85 90 95 Val Pro Met Val Thr Gly Leu Pro Leu He Wing He Val Leu Val Wing 20 100 105 110 Leu Phe He Gln Asp Leu Arg Thr Gly Val Wing Val Thr Val Pro Leu 115 120 125 Leu Met Cys Val Wing Val Leu Pro Val Val Wing Arg Trp Thr Leu Lys 130 135 140 Arg Wing Arg Glu Leu Arg Lys Lys Arg Gly Arg Met Wing Wing Arg He 145 150 155 160 Wing Asp Ser Val Met Wing Gly Glu Leu Leu His Wing Thr Gly Wing He 165 170 175 Asp Arg Glu Leu Asn Wing Val Thr Arg Asp Ser Asp Arg Val Val He 180 185 190 Wing Wing Val Arg Arg Ser Trp Wing Thr Gly Phe Ser Arg Wing Leu Met 25 1 95 200 205 Wing Met Wing Wing Ser Leu Gly Thr Val Ser He Val He Ser Gly His 210 215 220 Leu Glu Val Ser Glu Val Wing Gly He Met Met Leu Leu Gly Val Leu 225 230 235 240 Wing Thr Pro Val Wing Glu Leu Gly Arg Val Val Glu Tyr Arg Gln Asn 245 250 255 Tyr Lys Wing Wing Thr Arg He Leu He Pro Leu Leu Gln Arg Gly Ser 260 265 270 Glu Phe Lys His Ser Gln Gln Lys Leu Pro Gly Leu Gln Ala Thr Glu 275 280 285 Gly He Pro Gly Val Tyr Val Lys Gly He Ser Ala Leu Pro Gly Glu 290 295 300 Arg He Tyr Leu His Gly Ser Wing Asp Wing Thr Arg Lys Trp Val Thr 305 310 315 320 Be Leu Be Wing Met Glu Glu Gly Thr Asp Val He Val Asn Gly Gln 325 330 335 Arg Leu Ser Gln Leu Pro Leu Lys Gln Arg Arg Ala Leu He Gly He 340 345 350 Wing Ser Wing His His His Leu Ser Arg Gly Ser Val Ser Arg Leu Val 355 360 365 Gly Leu Arg Val Pro Asp Wing Thr Val Glu Glu He Glu Gln Ala Leu 370 375 380 Glu Gln Val Gly Leu Asn Asn Thr Gly Lys Gln Arg Leu Lys Asn Gly 385 390 395 400 Gly His Pro Trp Ser Thr Ser Gln He Asn Lys Leu Lys He Wing Ser 405 410 415 Wing Thr Leu Arg Thr Pro Pro Leu Leu Val Leu Glu Gly He Thr Pro 420 425 430 Glu Asn Leu Leu Asn Tyr Pro Gly Val He He Ser Thr Val Gln Glu 435 440 445 Asn Pro Ser Glu Thr Trp Arg Gln Val Asn He 450 455 < 210 > 303 < 211 > 412 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (412) < 223 > FRXA00456 < 400 > 303 ctcaccaacc cggagatcgt cacagcggtg ctaacggatc atgcctagct tatggcgtgc 60 tcgtcgcaga cttttgctca ttgccctagg tgtacttggt gtg ctg cag gca ctg 115 Val Leu Gln Ala Leu 1 5 ctg gcg ate atg gtg tcg ttg age gta gcc gcc ata ctt gag gga aac 163 Leu Ala He Met Val Ser Leu Ser Val Ala Ala He Leu Glu Gly Asn 10 15 20 cga gca ctt gtt gt ttg ctg ctt gct acc acg ttg ggt ttg ggg gtg 211 Arg Ala Leu Val Gly Leu Leu Leu Ala Thr Thr Leu Gly Leu Gly Val 25 30 35 gcg cag tgg att caa aaa gta gtg gca gaa gat cta ggc cag cat tat 259 Wing Gln Trp He Gln Lys Val Val Wing Glu Asp Leu Gly Gln His Tyr 40 45 50 gtg cat gag gtg cgt cgt gaa ttg gtg ggt gct gcg ctg gtg ect gga 307 Val His Glu Val Arg Arg Glu Leu Val Gly Ala Ala Leu Val Pro Gly 55 60 65 aat acg gcc tcg ttg ggc gtg act gtc acc gga age aat gat 355 Asn Thr Ala Ser Leu Gly Val Thr Val Thr Arg Ala Ser Asn Asp Leu 70 75 80 85 acc gcg gtg cgc aat tgg gtg gct ttg ggc att gtt ccg atg gtc acc 403 Thr Ala Val Arg Asn Trp Val Ala Leu Gly He Val Pro Met Val Thr 90 95 100 • ggg ctg ccg 412 Gly Leu Pro < 210 > 304 < 211 > 104 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 304 Val Leu Gln Ala Leu Leu Ala He Met Val Ser Leu Ser Val Ala Ala 10 1 5 10 15 He Leu Glu Gly Asn Arg Ala Leu Val Gly Leu Leu Leu Wing Thr Thr 20 25 30 Leu Gly Leu Gly Val Wing Gln Trp He Gln Lys Val Val Wing Glu Asp • 35 40 45 Leu Gly Gln His Tyr Val His Glu Val Arg Arg Glu Leu Val Gly Wing 50 55 60 Wing Leu Val Pro Gly Asn Thr Wing Ser Leu Gly Val Thr Val Thr Arg 65 70 75 80 Wing Being Asn Asp Leu Thr Wing Val Arg Asn Trp Val Wing Leu Gly He 85 90 95 Val Pro Met Val Thr Gly Leu Pro 15 100 < 210 > 305 < 211 > 1040 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS • < 222 > (31) .. (1017) < 223 > FRXA00459 20 < 400 > 305 aggcgtggct gttactgtge cactgctcat gtg tgt acc cgt gct gcc ggt ggt 54 Val Cys Thr Arg Wing Wing Gly Gly 1 5 ggc gcg gtg act ttg aaa aga gca cgt gaa cta cgc aaa aaa ccggtt ggggaa 102 Gly Ala Val Thr Leu Lys Arg Ala Arg Glu Leu Arg Lys Lys Arg Gly 10 15 20 cgc atg gct gcg cgg ate gca gat tet gtc atg gct gga gaa ttttaa ccttgg 150 Arg Met Wing Wing Arg He Wing Asp Ser Val Met Wing Gly Glu Leu Leu 25 30 35 40 falls gca here gga gca ata gac cgt gag etc aat gca gtc acc ccggaa ggaatt 198 His Wing Thr Gly Wing He Asp Arg Glu Leu Asn Wing Val Thr Arg Asp 25 45 50 55 __._ _____, - &,. & -i ... tc gac cga gtg gtg ata gct gct gta aga cgt tcc tgg gcc acc ggt 246 Ser Asp Arg Val Val He Ala Wing Wing Arg Arg Ser Trp Wing Thr Gly 60 65 70 ttt age cgc gca ttg atg gcc atg gca gcc tcg ctt ggc act gtc age 294 Phe Ser Arg Ala Leu Met Ala Ala Ala Ala Ser Leu Gly Thr Val Ser 75 80 85 att gtg att tet ggc falls ctg gaa gt agt gag gtt gg gga ata atg 342 He Val He Ser Gly His Leu Glu Val Ser Glu Val Wing Gly He Met 90 95 100 atg ctt ctt gtt gtt ctt gcc act cca gtt gca gaa ctt ggc cgc gtg 390 Met Leu Leu Gly Val Leu Ala Thr Pro Val Ala Glu Leu Gly Arg Val 105 110 115 120 gtg gaa tat cgc ca aat tat aaa gcc gcg here cgc ate ctg att cca 438 Val Glu Tyr Arg Gln Asn Tyr Lys Wing Wing Thr Arg He Leu He Pro 125 130 135 ctt ctg caa cga ggc tea gaa ttt aaa falls tcc caá caa aaa cta ccc 486 Leu Leu Gln Arg Gly Ser Glu Phe Lys His Ser Gln Gln Lys Leu Pro 140 145 150 ggg ttg cag gca here gaa gga ate ccc ggt gtc tat gtc aaa ggt att 534 Gly Leu Gln Ala Thr Glu Gly He Pro Gly Val Tyr Val L ys Gly He 10 155 160 165 tcc gcc ctt ect gga gaa cgg ate tac etc drops ggc tet gca gat gcg 582 Ser Ala Leu Pro Gly Glu Arg He Tyr Leu His Gly Ser Ala Asp Ala 170 180 • 175 acg aga aaa tgg gtc acc tcg ttg tet gca atg gag gaa ggc here gat 630 Thr Arg Lys Trp Val Thr Ser Leu Ser Wing Met Glu Glu Gly Thr Asp 185 190 195 200 gta ata gtc aac ggt caa agg ctt tcg cag ctt ect ttg aaa caa cga 678 Val He Val Asn Gly Gln Arg Leu Ser Gln Leu Pro Leu Lys Gln Arg 205 210 215 cgc gcc etc ate gga ate gcc tea gca cae cae falls tta age cgt ggt 726 Arg Ala Leu He Gly He Ala Ala Ala His His His Leu Ser Arg Gly 15 220 225 230 tea gta tcg cgc ctg gtt ggt ttg cga gtg ccg gat gcc acc gtg gaa 774 Ser Val Ser Arg Leu Val Gly Leu Arg Val Pro Asp Ala Thr Val Glu 235 240 245 gaa att gag ca gca ctg gaa ca gtt ggt ctg aac aac acc ggg aaa 822 Glu He Glu Gln Ala Leu Glu Gln Val Gly Leu Asn Asn Thr Gly Lys 250 255 260 caca cgc ttg aaa aac ggc gga cae ccc tgg agt act tcg cag ate aac 870 • Gln Arg Leu Lys Asn Gly Gly His Pro Trp Ser Thr Ser Gln He Asn 265 270 275 280 aaa ctg aaa att gcc age gcc acc ctt cga acc cca ccg ctt ttg gta 918 Lys Leu Lys He Ala Ser Ala Thr Leu Arg Thr Pro Pro Leu Leu Val 20 285 290 295 ctt gaa ggc ate acc ect gaa aac etc etc aac tat ccc gga gtg ate 966 Leu Glu Gly He Thr Pro Glu Asn Leu Leu Asn Tyr Pro Gly Val He 300 305 310 ate tcc acc gtt cag gag aac cca tcc gaa here tgg cgg ca gtg aac 1014 Be Ser Thr Val Gln Glu Asn Pro Ser Glu Thr Trp Arg Gln Val Asn 315 320 325 ate taatctagaa acatggcagg ac; g 1040 He < 210 > 306 25 < 211 > 329 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 306 Val Cys Thr Arg Ala Ala Gly Gly Gly Ala Val Thr Leu Lys Arg Ala 1 5 10 15 Arg Glu Leu Arg Lys Lys Arg Gly Arg Met Wing Wing Arg He Wing Asp 20 25 30 Ser Val Met Wing Gly Glu Leu Leu His Wing Thr Gly Wing He Asp Arg 35 40 45 Glu Leu Asn Wing Val Thr Arg Asp Ser Asp Arg Val Val He Ala Wing 50 55 60 Val Arg Arg Ser Trp Wing Thr Gly Phe Ser Arg Wing Leu Met Wing Met 65 70 75 80 Wing Wing Being Leu Gly Thr Val Being He Val He Being Gly His Leu Glu 85 90 95 Val Ser Glu Val Wing Gly He Met Met Leu Leu Gly Val Leu Wing Thr 100 105 110 Pro Val Wing Glu Leu Gly Arg Val Val Glu Tyr Arg Gln Asn Tyr Lys 115 120 125 Wing Wing Thr Arg He Leu He Pro Leu Leu Gln Arg Gly Ser Glu Phe 130 135 140 Lys His Ser Gln Gln Lys Leu Pro Gly Leu Gln Wing Thr Glu Gly He 145 150 155 160 Pro Gly Val Tyr Val Lys Gly He Ser Wing Leu Pro Gly Glu Arg He 165 170 175 Tyr Leu His Gly Ser Wing Asp Wing Thr Arg Lys Trp Val Thr Ser Leu 180 185 190 Being Wing Met Glu Glu Gly Thr Asp Val He Val Asn Gly Gln Arg Leu 195 200 205 Ser Gln Leu Pro Leu Lys Gln Arg Arg Ala Leu He Gly He Wing Being 210 215 220 Ala His His His Leu Ser Arg Gly Ser Val Ser Arg Leu Val Gly Leu 225 230 235 240 Arg Val Pro Asp Wing Thr Val Glu Glu He Glu Gln Wing Leu Glu Gln 245 250 255 Val Gly Leu Asn Asn Thr Gly Lys Gln Arg Leu Lys Asn Gly Gly His 260 265 270 Pro Trp Ser Thr Ser Gln He Asn Lys Leu Lys He Wing Ser Ala Thr 275 280 285 Leu Arg Thr Pro Pro Leu Leu Val Leu Glu Gly He Thr Pro Glu Asn 290 295 300 Leu Leu Asn Tyr Pro Gly Val He He Ser Thr Val Gln Glu Asn Pro 305 310 315 320 Ser Glu Thr Trp Arg Gln Val Asn He 325 < 210 > 307 < 211 > 771 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (748) < 223 > RXN01604 < 400 > 307 etetcatgtt gttgtectet agttgacage gggggtgiggttgg gtggtcctaa, aataigeetac 60 gataactgat agtgtttcct ccacttacgg aagaagaattaacc atg aat acc ect ctt 115 Met Asn Thr Pro Leu 1 5 ttg aga age tet ggg etc tcc ate cgc gac here ccc ttc gcc gat gtt 163 Leu Arg Ser Ser Gly Leu Ser He Arg Asp Thr Pro Phe Wing Asp Val 10 15 20 • gag ata gct cca gac age gga etc act ttg ctg age acc ggg cgc gaa 211 Glu He Wing Pro Asp Ser Gly Leu Thr Leu Leu Ser Thr Gly Arg Glu 25 30 35 tcc caà tcc agt tcc ttt tet ttg gta ctt tcc ggc cgc atg cgc gcc 259 Ser Gln Ser Be Ser Phe Ser Leu Val Leu Ser Gly Arg Met Arg Wing 40 45 50 tcc acc gga acc ate gaa tta aac ggc gaa ccc ate aag gca acc aag 307 Ser Thr Gly Thr He Glu Leu Asn Gly Glu Pro He Lys Wing Thr Lys 55 60 65 ctg gcc aag cat gtg gct tg gcg ggc ate ect gaa ate gat tea etc. 355 Leu Ala Lys His Val Ala Leu Ala Gly He Pro Glu He Asp Ser Leu 70 75 80 85 10 gag cga ctt gtc act gtg cgc acc gtt gtc cgt gaa cac etc gcc tgg 403 Glu Arg Leu Val Thr Val Arg Thr Val Val Arg Glu Gln Leu Wing Trp 90 95 100 tea age ect tgg tac ctg atg gtg ccc agg gat att agt gat tcg gga 451 • Be Ser Pro Trp Tyr Leu Met Val Pro Arg Asp Be As Asp Ser Gly 105 110 115 cgg tgg gtt gac gtc gaa aag cat ctt ggc ctg aac ctg aac ect aaa 499 Arg Trp Val Asp Val Glu Lys His Leu Gly Leu Asn Leu Asn Pro Lys 120 125 130 acc tta ate ggc gac etc age gtg etc gag cgt ttt aag ctg cgc ate 547 Thr Leu He Gly Asp Leu Ser Val Leu Glu Arg Phe Lys Leu Arg He 135 140 145 15 gcg ctg gcg ctg ctg gcg cgg cca gag gcg caá ctg ttg gtc gtg gat 595 Wing Leu Wing Leu Leu Wing Arg Pro Glu Wing Gln Leu Leu Val Val Asp 150 155 160 165 gat ccc gat ca gtg cgc age atg gaa ttg cgt gcg gag gtg ttg falls 643 Asp Pro Asp Gln Val Arg Ser Met Glu Leu Arg Wing Glu Val Leu His 170 175 180 gca ttg aaa ggc gtt gca gag gat etc ect gtg gtc gtg gta tcc acc 691 Wing Leu Lys Gly Val Wing Glu Asp Leu Pro Val Val Val Val Ser Thr • 185 190 195 aac cca gat ttt gat tcc ttg gcc gat acc gct ttg action att acg ggg 739 Asn Pro Asp Phe Asp Ser Leu Wing Asp Thr Wing Leu Thr He Thr Gly 200 205 210 2 gct gga aac taatggcatt tttacacttt ggc 771 Wing Gly Asn 215 <; 210 > 308 < 211 > 216 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 308 Met Asn Thr Pro Leu Leu Arg Ser Ser Gly Leu Ser He Arg Asp Thr 1 5 10 15 25 Pro Phe Wing Asp Val Glu He Al Pro Pro Asp Ser Gly Leu Thr Leu Leu "- -i i. 20 25 30 Being Thr Gly Arg Glu Being Gln Being Being Phe Being Leu Val Leu Being 35 40 45 Gly Arg Met Arg Wing Being Thr Gly Thr He Glu Leu Asn Gly Glu Pro 50 55 60 He Lys Wing Thr Lys Leu Wing Lys His Val Ala Leu Ala Gly He Pro 65 70 75 80 Glu He Asp Ser Leu Glu Arg Leu Val Thr Val Arg Thr Val Val Arg 85 90 95 • Glu Gln Leu Wing Trp Ser Ser Pro Trp Tyr Leu Met Val Pro Arg Asp 100 105 110 I Am Ser Asp Ser Gly Arg Trp Val Asp Val Glu Lys His Leu Gly Leu 115 120 125 Asn Leu Asn Pro Lys Thr Leu He Gly Asp Leu Ser Val Leu Glu Arg 130 135 140 Phe Lys Leu Arg He Ala Leu Ala Leu Leu Ala Arg Pro Glu Ala Gln 145 150 155 160 Leu Leu Val Val Asp Asp Pro Asp Gln Val Arg Ser Met Glu Leu Arg 165 170 175 Wing Glu Val Leu His Wing Leu Lys Gly Val Wing Glu Asp Leu Pro Val 180 185 190 10 Val Val Val Ser Thr Asn Pro Asp Phe Asp Ser Leu Wing Asp Thr Wing 195 200 205 Leu Thr He Thr Gly Wing Gly Asn • 210 215 < 210 > 309 < 211 > 629 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > 15 < 221 > CDS < 222 > (1) .. (606) < 223 > FRXA01604 < 400 > 309 gac here ccc ttc gcc gat gtt gag ata gct cca gac age gga etc act 48 Asp Thr Pro Phe Wing Asp Val Glu He Wing Pro Asp Ser Gly Leu Thr 1 5 10 15 ttg ctg age acc ggg cgc gaa tcc ca tcc agt tcc ttt tet ttg gta 96 • Leu Leu Being Thr Gly Arg Glu Being Gln Ser Being Being Phe Ser Leu Val 20 25 30 ctt tcc ggc cgc atg cgc gcc tcc acc gga acc ate gaa tta aac ggc 144 20 Leu Ser Gly Arg Met Arg Wing Being Thr Gly Thr He Glu Leu Asn Gly 35 40 45 gaa ccc ate aag gca acc aag ctg gcc aag cat gtg gct ttg gcg ggc 192 Glu Pro He Lys Wing Thr Lys Leu Wing Lys His Val Wing Leu Wing Gly 50 55 60 ate ect gaa ate gat tea etc gag cga ctt gtc act gtg cgc acc gtt 240 He Pro Glu He Asp Ser Leu Glu Arg Leu Val Thr Val Arg Thr Val 65 70 75 80 gtc cgt gaa caa etc gcc tgg tea age ect tgg tac ctg atg gtg ccc 288 Val Arg Glu Gln Leu Wing Trp Ser Ser Pro Trp Tyr Leu Met Val Pro 85 90 95 agg gat att agt gat tcg gga cgg tgg gtt gac gtc gaa aag cat ctt 336 25 Ar9 Asp He Ser Asp Ser Gly Arg Trp Val Asp Val Glu Lys His Leu 100 105 110 ggc ctg aac ctg aac ect aaa acc tta ate ggc gac etc age gtg etc 384 Gly Leu Asn Leu Asn Pro Lys Thr Leu He Gly Asp Leu Ser Val Leu 115 120 125 gag cgt ttt aag ctg cgc ate gcg ctg gcg ctg ctg gcg cgg cca gag 432 Glu Arg Phe Lys Leu Arg He Wing Leu Wing Leu Leu Wing Arg Pro Glu 130 135 140 gcg caa ctg ttg gtc gtg gat gat ccc gat ca gtg cgc age atg gaa 480 Wing Gln Leu Leu Val Val Asp Asp Pro Asp Gln Val Arg Ser Met Glu 145 150 155 160 ttg cgt gcg gag gtg ttg falls gca ttg aaa ggc gtt gca gag gat etc 528 Leu Arg Wing Glu Val Leu His Wing Leu Lys Gly Val Wing Glu Asp Leu 165 170 175 ect gtg gtg gta tcc acc aac cca gat ttt gat tcc ttg gcc gat 576 Pro Val Val Val Val Ser Thr Asn Pro Asp Phe Asp Ser Leu Wing Asp 180 185 190 ac gct ttg acc att acg ggg gga aac taatggcatt tttacacttt 626 Thr Ala Leu Thr He Thr Gly Wing Gly Asn 195 200 ggc 629 < 210 > 310 < 211 > 202 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 310 Asp Thr Pro Phe Wing Asp Val Glu He Wing Pro Asp Ser Gly Leu Thr 1 5 10 15 Leu Leu Ser Thr Gly Arg Glu Ser Gln Ser Ser Phe Ser Leu Val 20 25 30 Leu Ser Gly Arg Met Arg Ala Ser Thr Gly Thr He Glu Leu Asn Gly 35 40 45 Glu Pro He Lys Wing Thr Lys Leu Wing Lys His Val Wing Leu Wing Gly 50 55 60 He Pro Glu He Asp Ser Leu Glu Arg Leu Val Thr Val Arg Thr Val 65 70 75 80 Val Arg Glu Gln Leu Wing Trp Ser Ser Pro Trp Tyr Leu Met Val Pro 85 90 95 Arg Asp Be Ser Asp Ser Gly Arg Trp Val Asp Val Glu Lys His Leu 100 105 110 Gly Leu Asn Leu Asn Pro Lys Thr Leu He Gly Asp Leu Ser Val Leu 115 120 125 Glu Arg Phe Lys Leu Arg He Ala Leu Ala Leu Leu Ala Arg Pro Glu 130 135 140 Wing Gln Leu Leu Val Val Asp Asp Pro Asp Gln Val Arg Ser Met Glu 145 150 155 160 Leu Arg Ala Glu Val Leu His Wing Leu Lys Gly Val Wing Glu Asp Leu 165 170 175 Pro Val Val Val Val Ser Thr Asn Pro Asp Phe Asp Ser Leu Wing Asp 180 185 190 Thr Wing Leu Thr He Thr Gly Wing Gly Asn 195 200 < 210 > 311 < 211 > 2262 < 212 > DNA _ij_ < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (2239) < 223 > RXN02547 < 400 > 311 ggggccgtcg ataagcgaag aacaattage actgcgcgcg ctggtctgac geattggtta 60 • aggggctggc ggtccggcgc cggaatcggc ggaggagctt ttg gag etc aac aac 115 Leu Glu Leu Asn Asn 1 5 gct gcg cgg ctg acc gtg gat gag tat ccg gcg gcg agg gaa gcg ctt 163 Wing Wing Arg Leu Thr Val Asp Glu Tyr Pro Wing Wing Arg Glu Wing Leu 10 15 20 gaa tet gca ggt cag agg aat gta gag gaga cga acc cgt gcg gtt gat 211 Glu Be Wing Gly Gln Arg Asn Val Glu Asp Arg Thr Arg Wing Val Asp 25 30 35 gag ttc aaa gcg gcg gat ca gag ctg tet tet ttg agt aaa ggc age 259 Glu Phe Lys Wing Wing Asp Gln Glu Leu Ser Ser Leu Ser Lys Gly Ser 40 45 50 10 agt aat att gag tac cgt ttg ctg cag gtg cgg gaa aat ttg tgt cag 307 Ser Asn He Glu Tyr Arg Leu Leu Gln Val Arg Glu Asn Leu Cys Gln 55 60 65 gat ttg ggc gtg age ccg cgg gat atg ccc ttt gcc ggt gag ctg att 355 Asp Leu Gly Val Pro Pro Arg Asp Met Pro Phe Wing Gly Glu Leu He 70 75 80 85 gat ccg aat aat gcg gaa tgg gaa ccc gtt gtg cag cgc att ttg ggt 403 Asp Pro Asn Asn Wing Glu Trp Glu Pro Val Val Gln Arg He Leu Gly 90 95 100 ggt ttt gcg gaa atg ttg gtt ect c at ggg ttg ttg cca cgg ggg 451 Gly Phe Wing Wing Glu Met Leu Val Pro His Gly Leu Pro Arg Val 15 105 110 115 cgg gat tgg gta aat gcc aaa cat ttg gca gcg ctg ctg aaa ttc aac 499 Arg Asp Trp Val Asn Wing Lys His Leu Wing Wing Leu Leu Lys Phe Asn 120 125 130 gg gtg gtg here acg ggg gag tac aaa acc tcg cgt ttt ccg gcg gat 547 Gly Val Val Thr Thr Gly Glu Tyr Lys Thr Ser Arg Phe Pro Wing Asp 135 140 145 tcc ctg ate cga aaa gtt gat gtt gtg gag tcg ccg ttt cgc gat tgg 595 Ser Leu He Arg Lys Val Asp Val Val Glu Ser Pro Phe Arg Asp Trp 150 155 160 165 gta aat caa gaa tta ggc aag cgt ttt aat att cgg tgc gtg cgc act 643 Val Asn Gln Glu Leu Gly Lys Arg Phe Asn He Arg Cys Val Arg Thr 20 170 175 180 ect gag gaa ttg tcg gcg ctg ggg cca cgc gat cag ggc gtg acc att 691 Pro Glu Glu Leu Ser Ala Leu Gly Pro Arg Asp Gln Gly Val Thr He 185 190 195 ttg ggt gtg cga aaa ttt gcg cag cag here ggc gat ccg acg acg cgt 739 Leu Gly Val Arg Lys Phe Wing Gln Gln Thr Gly Asp Pro Thr Thr Arg 200 205 210 tgg gaa aaa gat gat cgc cga aag ctg ggg gat cgt tcc here tac cgt 787 Trp Glu Lys Asp Asp Arg Arg Lys Leu Gly Asp Arg Ser Thr Tyr Arg 215 220 225 ttg ggt tcc acc aat gat gcc aag gtg gaa acg ctt cgg gaa acc gtg 835 Leu Gly Ser Thr Asn Asp Ala Lys Val Glu Thr Leu Arg Glu Thr Val 25 230 235 240"245 • - '- > *.?. »I. aaa gct ggc aaa gca gtt gtg cag gca gct gat aat cgc att gct gca 883 Lys Wing Gly Lys Wing Val Val Gln Wing Wing Asp Asn Arg He Wing Wing 250 255 260 aac cgc gct gag ctg cgg gaa ctt gaa cgg cag tat ca gct tcg ca 931 Asn Arg Ala Glu Leu Arg Glu Leu Glu Arg Gln Tyr Gln Ala Ser Gln 265 270 275 gaa att ttg aaa gtg tcg tgg gct cag att gat gtg gaa tea gcc gac 979 Glu He Leu Lys Val Ser Trp Wing Gln He Asp Val Glu Ser Wing Asp 280 285 290 gcg gcg att gct gag ctg gac cga ttg ctg gaa gag ctg aac aac act 1027 Wing Wing Wing Glu Leu Asp Arg Leu Leu Glu Glu Leu Asn Asn Thr 295 300 305 cca gag gcc acc gag ctt tcc gcg cgg cat gag gcg gcg aag cag acg 1075 Pro Glu Ala Thr Glu Leu Ser Ala Arg His Glu Ala Ala Lys Gln Thr 310 315 320 325 etc gcg agg gtt tet gac ttg ctt gtc gca gct cag agt gag gaa acc 1123 Leu Ala Arg Val Ser Asp Leu Leu Val Ala Ala Gln Ser Glu Glu Thr 330 335 340 gtg gcg tcg atg aac ctg aaa cgc gcc gaa act gaa ttg aaa cgg etc 1171 Val Ala Ser Met Asn Leu Lys Arg Ala Glu Thr Glu Leu Lys Arg Leu 345 350 355 gaa age ctg ccg gtt gcg gag gtt tet gaa gaa ate gcg cgg gaa gtg 1219 Glu Ser Leu Pro Val Wing Glu Val Ser Glu Glu He Wing Arg Glu Val 360 365 370 gag aaa cta ttt ctt gcc aac acc cgc cgg gtt drops gcc gee aac gtg 1267 Glu Lys Leu Phe Leu Wing Asn Thr Arg Arg Val His Wing Wing Asn Val 375 380 385 gat gag cag acc att gcg ctg cgc gag gat ctg gac aaa caa ate gat 1315 Asp Glu Gln Thr He Wing Leu Arg Glu Asp Leu Asp Lys Gln He Asp 390 395 400 405 gcc aat gag gca gaa ctt cga cgt tgt gaa aac caa att gtt ggc att 1363 Wing Asn Glu Wing Glu Leu Arg Arg Cys Glu Asn Gln He Val Gly He 410 415 420 ttg cgc age tat att gaa acg tgg ect gcg aac cgc gct gac tta caa 1411 Leu Arg Ser Tyr He Glu Thr Trp Pro Wing Asn Arg Wing Asp Leu Gln 425 430 435 gcc gaa ect gag ttt gtt ggt gag gcc ate aac cgc etc ggc gag ctt 1459 Wing Glu Pro Glu Phe Val Gly Glu Wing He Asn Arg Leu Gly Glu Leu 440 445 450 cgc age gat cgt ttg gca gaa ttc acg gcc aaa ttc cta ggg etc atg 1507 Arg Ser Asp Arg Leu Wing Glu Phe Thr Wing Lys Phe Leu Gly Leu Met 455 460 465 aac gag atg tcc acc cga aac etc ggc ca ate tcg cgg cgt cta cgt 1555 Asn Glu Met Being Thr Arg Asn Leu Gly Gln He Being Arg Arg Leu Arg 470 475 480 485 gat gcg cgc cgg gaa ate gag gag cgc ate gag ccg ate aac gcc tcc 1603 Asp Wing Arg Arg Glu He Glu Glu Arg He Glu Pro He Asn Wing Ser 490 495 500 ttg gcg cag tcg gaa ttc aac gaa ggt cgc ttc ctg falls ate gac ate 1651 Leu Ala Gln Ser Glu Phe Asn Glu Gly Arg Phe Leu His He Asp He 505 510 515 cgt gat ca gt gtg gtg gtg gtg agg gaa ttc cag cag aaa ctt gat 1699 Arg Asp Gln Ser Gly Pro He Val Arg Glu Phe Gln Gln Lys Leu Asp 520 525 530 gcc gct action ggt gac ctg gga acc agt gag aaa caac gcc ttc 1747 Ala Ala Thr Ser Gly Asp Leu Gly Thr Ser Thr Glu Lys Gln Ala Phe 535 540 545 gcc cgt. tat gcg ctg ate gct gaa ate att tcc aaa etc gcc tcc falls 1795 Ala Arg Tyr Ala Leu He Ala Glu He He Ser Lys Leu Ala Ser His 550 555 560 565 gac tcc gcc gac gcc cgc tgg cgc aac acc gtt cta gac acc cgc cgc 1843 Asp Ser Wing Asp Wing Arg Trp Arg Asn Thr Val Leu Asp Thr Arg Arg 570 575 580 falls gtt cgc ttc ate ggc etc gag cgc gat tcc gac ggc gca acc gtc 1891 His Val Arg Phe He Gly Leu Glu Arg Asp Ser Asp Gly Ala Thr Val 585 590 595 • aac ac tc gc tc gc tc gca tea ctt tea ggc gga ca gcc cag aag 1939 Asn Thr Tyr Val Asp Ser Wing Ser Leu Ser Gly Gly Gln Wing Gln Lys 600 605 610 ctg gtg ttt ttc tgc etc gcc gct gcc ttg cgc tac cag cta gcc gaa 1987 Leu Val Phe Phe Cys Leu Wing Wing Wing Leu Arg Tyr Gln Leu Wing Glu 615 620 625 ccc ggc gcc cat tat ccc acc tac gcc acc gtc att ctg gac gaa gcc 2035 Pro Gly Ala His Tyr Pro Thr Tyr Wing Thr Val He Leu Asp Glu Wing 630 635 640 645 tcc gac cgc gcc gac ccc gcc tcc acccg ca cac acc at tc a cc tcc 2083 Phe Asp Arg Wing Asp Pro Wing Phe Thr Arg Gln Thr Met Asn Val Phe 10 650 655 660 falls age ttc ggc ttc falls atg gtg etc gcg acc ccg ctg aaa ctt ate 2131 His Ser Phe Gly Phe His Met Val Leu Wing Thr Pro Leu Lys Leu He 665 670 675 • caà acc etc ggc gat tat gtc ggc tcc acc ate gtg gtc age tac acc 2179 Gln Thr Leu Gly Asp Tyr Val Gly Ser Thr He Val Val Be Tyr Thr 680 685 690 gaa aaa cca aac gcc cag ggc gca att cag ggc aat tcc agt ttc tet 2227 Glu Lys Pro Asn Ala Gln Gly Ala He Gln Gly Asn Ser Ser Phe Ser 695 700 705 agg ate gag aaa taacatgeca ttgtttatcg acg 2262 Arg He Glu Lys 15 710 < 210 > 312 < 211 > 713 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 312 Leu Glu Leu Asn Asn Wing Wing Arg Leu Thr Val Asp Glu Tyr Pro Wing • 1 5 10 15 Wing Arg Glu Wing Leu Glu Wing Wing Gly Gln Arg Asn Val Glu Asp Arg 20 25 30 2Q Thr Arg Wing Val Asp Glu Phe Lys Ala Ala Asp Gln Glu Leu Ser Ser 35 40 45 Leu Ser Lys Gly Ser Ser Asn He Glu Tyr Arg Leu Leu Gln Val Arg 50 55 60 Glu Asn Leu Cys Gln Asp Leu Gly Val Ser Pro Arg Asp Met Pro Phe 65 70 75 80 Wing Gly Glu Leu He Asp Pro Asn Asn Wing Glu Trp Glu Pro Val Val 85 90 95 Gln Arg He Leu Gly Gly Phe Wing Wing Glu Met Leu Val Pro His Gly 100 105 110 Leu Leu Pro Arg Val Arg Asp Trp Val Asn Wing Lys His Leu Ala Ala 115 120 125 25 Leu Leu Lys Phe Asn Gly Val Val Thr Thr Gly Glu Tyr Lys Thr Ser 130 135 140 Arg Phe Pro Wing Asp Ser Leu He Arg Lys Val Asp Val Val Glu Ser 145 150 155 160 Pro Phe Arg Asp Trp Val Asn Gln Glu Leu Gly Lys Arg Phe Asn He 165 170 175 Arg Cys Val Arg Thr Pro Glu Glu Leu Ser Wing Leu Gly Pro Arg Asp 180 185 190 Gln Gly Val Thr He Leu Gly Val Arg Lys Phe Wing Gln Gln Thr Gly 195 200 205 • Asp Pro Thr Arg Trp Glu Lys Asp Asp Arg Arg Lys Leu Gly Asp 210 215 220 Arg Ser Thr Tyr Arg Leu Gly Ser Thr Asn Asp Wing Lys Val Glu Thr 225 230 235 240 Leu Arg Glu Thr Val Lys Wing Gly Lys Wing Val Val Gln Wing Wing Asp 245 250 255 Asn Arg He Wing Wing Asn Arg Wing Glu Leu Arg Glu Leu Glu Arg Gln 260 265 270 Tyr Gln Ala Ser Gln Glu He Leu Lys Val Ser Trp Wing Gln He Asp 275 280 285 Val Glu Ser Wing Asp Wing Wing He Wing Wing Glu Leu Asp Arg Leu Leu Glu 10 290 295 300 Glu Leu Asn Asn Thr Pro Glu Ala Thr Glu Leu Ser Ala Arg His Glu 305 310 315 320 Ala Ala Lys Gln Thr Leu Ala Arg Val Ser Asp Leu Leu Val Ala Ala • 325 330 335 Gln Ser Glu Glu Thr Val Ala Ser Met Asn Leu Lys TO, rg Ala Glu Thr 340 345 350 Glu Leu Lys Arg Leu Glu Ser Leu Pro Val Wing Glu Val Ser Glu Glu 355 360 365 He Wing Arg Glu Val Glu Lys Leu Phe Leu Wing Asn Thr Arg Arg Val 370 375 380 His Ala Wing Asn Val Asp Glu Gln Thr He Wing Wing Leu Arg Glu Asp Leu 15 385 390 395 400 Asp Lys Gln He Asp Wing Asn Glu Wing Glu Leu Arg Arg Cys Glu Asn 405 410 415 Gln He Val Gly He Leu Arg Ser Tyr He Glu Thr Trp Pro Wing Asn 420 425 430 Arg Wing Asp Leu Gln Wing Glu Pro Glu Phe Val Gly Glu Wing He Asn 435 440 445 Arg Leu Gly Glu Leu Arg Ser Asp Arg Leu Wing Glu Phe Thr Wing Lys 450 455 460 • Phe Leu Gly Leu Met Asn Glu Met Ser Thr Arg Asn Leu Gly Gln He 465 470 475 480 Ser Arg Arg Leu Arg Asp Wing Arg Arg Glu He Glu Glu Arg He Glu 20 485 490 495 Pro He Asn Wing Being Leu Wing Gln Being Glu Phe Asn Glu Gly Arg Phe 500 505 510 Leu His He Asp He Arg Asp Gln Ser Gly Pro He Val Arg Glu Phe 515 520 525 Gln Gln Lys Leu Asp Ala Wing Thr Ser Gly Asp Leu Gly Thr Ser Thr 530 535 540 Glu Lys Gln Wing Phe Wing Arg Ty r Ala Leu He Ala Glu He He Ser 545 550 555 560 Lys Leu Ala Ser His Asp Ser Wing Asp Wing Arg Trp Arg Asn Thr Val 565 570 575 Leu Asp Thr Arg Arg His Val Arg Phe He Gly Leu Glu Arg Asp Ser 25 580 585 590 ^^^^^^? Asp Gly Wing Thr Val Asn Thr Tyr Val Asp Ser Wing Ser Leu Ser Gly 595 600 605 Gly Gln Wing Gln Lys Leu Val Phe Phe Cys Leu Wing Wing Wing Wing Leu Arg 610 615 620 Tyr Gln Leu Wing Glu Pro Gly Wing His Tyr Pro Thr Tyr Ala Thr Val 625 630 635 640 He Leu Asp Glu Wing Phe Asp Arg Wing Asp Pro Wing Phe Thr Arg Gln 645 650 655 Thr Met Asn Val Phe His Ser Phe Gly Phe His Met Val Leu Wing Thr • 660 665 670 Pro Leu Lys Leu He Gln Thr Leu Gly Asp Tyr Val Gly Ser Thr He 675 680 685 Val Val Ser Tyr Thr Glu Lys Pro Asn Wing Gln Gly Wing He Gln Gly 690 695 700 Asn Being Ser Fhe Ser Arg He Glu Lys 705 710 < 210 > 313 < 211 > 2147 < 212 > DNA 10 < 213 > Ctaryntsbacterium glutamicum < 220 > < 221 > CDS • < 222 > (1) .. (2124) < 223 > FRXA02547 < 400 > .313 gct gcg cgg ctg acc gtg gat gag tat ccg gcg gcg agg gaa gcg ctt 48 Wing Wing Arg Leu Thr Val Asp Glu Tyr Pro Wing Wing Arg Glu Wing Leu 1 5 10 15 gaa tet gca ggt cag agg aat gta gag gac cga acc cgt gcg gtt gat 96 15 Glu Be Wing Gly Gln Arg Asn Val Glu Asp Arg Thr Arg Wing Val Asp 20 25 30 gag ttc aaa gcg gcg gat ca gag ctg tet tet ttg agt aaa ggc age 144 Glu Phe Lys Wing Wing Asp Gln Glu Leu Ser Ser Leu Ser Lys Gly Ser 35 40 45 agt aat att gag tac cgt ttg ctg cag gtg cgg gaa aat ttg tgt cag 192 Ser Asn He Glu Tyr Arg Leu Leu Gln Val Arg Glu Asn Leu Cys Gln 50 55 60 • gat ttg ggc gtg age ccg cgg gat atg ccc ttt gcc ggt gag ctg att 240 Asp Leu Gly Val Pro Pro Arg Asp Met Pro Phe Wing Gly Glu Leu He 65 70 75 80 gat ccg aat aat gcg gaa tgg gaa ccc gtt gtg cag cgc att ttg ggt 288 20 Asp Pro Asn Asn Wing Glu Trp Glu Pro Val Val Gln Arg He Leu Gly 85 90 95 ggt ttt gct gcg gaa atg ttg gtt ect cat ggg ttg ttg cca cgg gtt 336 Gly Phe Ala Ala Glu Met Leu Val Pro His Gly Leu Leu Pro Arg Val 100 105 110 cgg gat tgg gta aat gcc aaa cat ttg gca gcg ctg ctg aaa ttc aac 384 Arg Asp Trp Val Asn Wing Lys His Leu Wing Wing Leu Leu Lys Phe Asn 115 120 125 ggc gtg gtg here acg ggg gag tac aaa acc tcg cgt ttt ccg gcg gat 432 Gly Val Val Thr Thr Gly Glu Tyr Lys Thr Ser Arg Phe Pro Wing Asp 130 135 140 tcc ctg ate cga aaa gtt gat gtt gtg gag tcg ccg ttt cgc gat tgg 480 25 Ser Leu He Arg Lys Val Asp Val Val Glu Ser Pro Phe Arg Asp Trp - «-» «-» * 145 150 155 160 gta aat caa gaa tta ggc aag cgt ttt aat att cgg tgc gtg cgc act 528 Val Asn Gln Glu Leu Gly Lys Arg Phe Asn He Arg Cys Val Arg Thr 165 170 175 ect gag gaa ttg tcg gcg ctg ggg cca cgc gat cag ggc gtg acc att 576 Pro Glu Glu Leu Be Wing Leu Gly Pro Arg Asp Gln Gly Val Thr He 180 185 190 ttg ggt gtg cga aaa ttt gcg cag cag here ggc gat ccg acg acg cgt 624 Leu Gly Val Arg Lys Phe Wing Gln Gln Thr Gly Asp Pro Thr Thr Arg 195 200 205 tgg gaa aaa gat gat cgc cga aag ctg ggg gat cgt tcc here tac cgt 672 Trp Glu Lys Asp Asp Arg Arg Lys Leu Gly Asp Arg Ser Thr Tyr Arg 210 215 220 ttg ggt tcc acc aat gat gcc aag gtg gaa acg ctt cgg gaa acc gtg 720 Leu Gly Ser Thr Asn Asp Ala Lys Val Glu Thr Leu Arg Glu Thr Val 225 230 235 240 aaa gct ggc aaa gca gtt gtg cag gca gct gat aat cgc att gct gca 768 Lys Wing Gly Lys Wing Val Val Gln Wing Wing Asp Asn Arg Wing Wing 245 250 255 aac cgc gct gag ctg cgg gaa ctt gaa cgg cag tat ca gct tct g ca 816 10 Asn Arg Wing Glu Leu Arg Glu Leu Glu Arg Gln Tyr Gln Wing Wing Gln 260 265 270 gaa att ttg aaa gtg tcg tgg gct cag att gat gtg gaa tea gcc gac 864 Glu He Leu Lys Val Ser Trp Wing Gln He Asp Val Glu Ser Wing Asp • 275 280 285 gcg gcg att gct gag ctg gac cga ttg ctg gaa gag ctg aac aae act 912 Wing wing Wing Wing Glu Leu Asp Arg Leu Leu Glu Glu Leu Asn Asn Thr 290 295 300 cca gag gcc acc gag ctt tcc gcg cgg cat gag gcg gcg aag cag acg 960 Pro Glu Wing Thr Glu Leu Ser Wing Arg His Glu Wing Wing Lys Gln Thr 305 310 315 320 etc gcg agg gtt tet gac ttg ctt gtc gca gct cag agt gag gaa acc 1008 15 Leu Ala Arg Val Ser Asp Leu Leu Val Ala Ala Gln Ser Glu Glu Thr 325 330 335 gtg gcg tcg atg aac ctg aaa cgc gcc gaa act gaa ttg aaa cgg etc 1056 Val Ala Ser Met Asn Leu Lys Arg Ala Glu Thr Glu Leu Lys Arg Leu 340 345 350 gaa age ctg ccg gtt gcg gag gtt tet gaa gaa ate gcg cgg gaa gtg 1104 Glu Ser Leu Pro Val Wing Glu Val Ser Glu Glu He Wing Arg Glu Val 355 360 365 gag aaa cta ttt ctt gcc aac acc cgc cgg gtt drops gcc gcc aac gtg 1152 Glu Lys Leu Phe Leu Wing Asn Thr Arg Arg Val His Wing Wing Asn Val 370 375 380 gat gag cag acc att gcg ctg cgc gag gat ctg gac aaa caa ate gat 1200 20 Asp Glu Gln Thr He Wing Wing Leu Arg Glu Asp Leu Asp Lys Gln He Asp 385 390 395 400 gcc aat gag gca gaa ctt cga cgt tgt gaa aac caa att gtt ggc att 1248 Wing Asn Glu Wing Glu Leu Arg Arg Cys Glu Asn Gln He Val Gly He 405 410 415 ttg cgc age tat att gaa acg tgg ect gcg aac cgc gct gac tta caa 1296 Leu Arg Ser Tyr He Glu Thr Trp Pro Wing Asn Arg Wing Asp Leu Gln 420 425 430 gcc gaa ect gag ttt gtt ggt gag gcc ate aac cgc etc ggc gag ctt 1344 Wing Glu Pro Glu Phe Val Gly Glu Wing He Asn Arg Leu Gly Glu Leu 435 440 445 cgc age gat cgt ttg gca gaa ttc acg gcc aaa ttc cta ggg etc atg 1392 25 Arg Ser Asp Arg Leu Wing Glu Phe Thr Wing Lys Phe Leu Gly Leu Met 450 455 460 aac gag atg tcc acc cga aac etc ggc ca ate tcg cgg cgt cta cgt 1440 Asn Glu Met Ser Thr Arg Asn Leu Gly Gln He Be Arg Arg Leu Arg 465 470 475 480 gat gcg cgc cgg gaa ate gag gag cgc ate gag ccg ate aac gcc tcc 1488 Asp Ala Arg Arg Glu He Glu Glu Arg He Glu Pro He Asn Wing Ser 485 490 495 ttg gcg cag tcg gaa ttc aac gaa ggt cgc ttc ctg falls ate gac ate 1536 Leu Ala Gln Ser Glu Phe Asn Glu Gly Arg Phe Leu His He Asp He • 500 505 510 cgt gat ca gtt ag ggt ccg gtg agg gaa ttc cag aaa ctt gat 1584 Arg Asp Gln Ser Gly Pro He Val Arg Glu Phe Gln Gln Lys Leu Asp 515 520 525 gcc gct action ggt gac ctg gga acc gt acc acct gag aaa ca gcc ttc 1632 Wing Wing Thr Ser Gly Asp Leu Gly Thr Ser Thr Glu Lys Gln Wing Phe 530 535 540 gcc cgt tat gcg ctg ate gct gaa ate att tcc aaa etc gcc tcc cae 1680 Ala Arg Tyr Ala Leu He Ala Glu He He Ser Lys Leu Ala Ser His 545 550 555 560 gac tcc gcc gac gcc cgc tgg cgc aac acc gtt cta gac acc cgc cgc 1728 10 Asp Ser Wing Asp Wing Arg Trp Arg Asn Thr Val Leu Asp Thr Arg Arg 565 570 575 falls gtt cgc ttc ate ggc etc gag cgc gat tcc gac ggc gca acc gtc 1776 His Val Arg Phe He Gly Leu Glu Arg Asp Ser Asp Gly Wing Thr Val 580 585 590 aac acc tac gtc gac tcc gca tea ctt tea ggc gga ca gcc cag aag 1824 Asn Thr Tyr Val Asp Ser Wing Ser Leu Ser Gly Gly Gln Wing Gln Lys 595 600 605 ctg gtg ttt ttc tgc etc gcc gct gcc ttg cgc tac cag cta gcc gaa 1872 Leu Val Phe Phe Cys Leu Wing Wing Wing Leu Arg Tyr Gln Leu Wing Glu 610 615 620 ccc ggc gcc cat tat ccc acc tac gcc acc gtc att ctg gac gaa gcc 1920 15 Pro Gly Wing His Tyr Pro Thr Tyr Wing Thr Val He Leu Asp Glu Wing 625 630 635 640 ttc gac cgc gcc gac ccc gcc ttc acc cgc ca at acc atg aac gtc ttc 1968 Phe Asp Arg Wing Asp Pro Wing Phe Thr Arg Gln Thr Met Asn Val Phe 645 650 655 fall age ttc ggc ttc falls atg gtg etc gcg acc ccg ctg aaa ctt ate 2016 His Ser Phe Gly Phe His Met Val Leu Wing Thr Pro Leu Lys Leu He 660 665 670 caà acc etc ggc gat tat gtc ggc tcc acc ate gtg gtc age tac acc 2064 Gln Thr Leu Gly Asp Tyr Val Gly Ser Thr He Val Val Ser Tyr Thr 675 680 685 gaa aaa cca aac gcc cag ggc gca att cag ggc aat tcc agt ttc tet 2112 20 Glu Lys Pro Asn Ala Gln Gly Ala He Gln Gly Asn Ser Ser Phe Ser 690 695 700 agg ate gag aaa taacatgeca ttgtttatcg acg 2147 Arg He Glu Lys 705 < 210 > 314 < 211 > 708 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 314 25 Ala Ala Arg Leu Thr Val Asp Glu Tyr Pro Ala Ala Arg Glu Ala Leu * ** - • * * í * - 1 5 10 15 Glu Being Wing Gly Gln Arg Asn Val Glu Asp Arg Thr Arg Wing Val Asp 20 25 30 Glu Phe Lys Wing Wing Asp Gln Glu Leu Ser Ser Leu Ser Lys Gly Ser 35 40 45 Ser Asn He Glu Tyr Arg Leu Leu Gln Val Arg Glu Asn Leu Cys Gln 50 55 60 Asp Leu Gly Val Ser Pro Arg Asp Met Pro Phe Wing Gly Glu Leu He 65 70 75 80 • Asp Pro Asn Asn Wing Glu Trp Glu Pro Val Val Gln Arg He Leu Gly 85 90 95 Gly Phe Ala Ala Glu Met Leu Val Pro His Gly Leu Leu Pro Arg Val 100 105 110 Arg Asp Trp Val Asn Ala Lys His Leu Ala Ala Leu Leu Lys Phe Asn 115 120 125 Gly Val Val Thr Thr Gly Glu Tyr Lys Thr Ser Arg Phe Pro Wing Asp 130 135 140 Ser Leu He Arg Lys Val Asp Val Val Glu Ser Pro Phe Arg Asp Trp 145 150 155 160 Val Asn Gln Glu Leu Gly Lys Arg Phe Asn He Arg Cys Val Arg Thr 10 165 170 175 Pro Glu Glu Leu Be Ala Leu Gly Pro Arg Asp Gln Gly Val Thr He 180 185 190 Leu Gly Val Arg Lys Phe Ala Gln Gln Thr Gly Asp Pro Thr Thr Arg • 195 200 205 Trp Glu Lys Asp Asp Arg Arg Lys Leu Gly Asp Arg Ser Thr Tyr Arg 210 215 220 Leu Gly Ser Thr Asn Asp Ala Lys Val Glu Thr Leu Arg Glu Thr Val 225 230 235 240 Lys Ala Gly Lys Ala Val Val Gln Wing Wing Asp Asn Arg Wing Wing 245 250 255 Asn Arg Wing Glu Leu Arg Glu Leu Glu Arg Gln Tyr Gln Wing Being Gln 15 260 265 270 Glu He Leu Lys Val Ser Trp Wing Gln He Asp Val Glu Ser Wing Asp 275 280 285 Wing Wing Wing Glu Leu Asp Arg Leu Leu Glu Glu Leu Asn Asn Thr 290 295 300 Pro Glu Wing Thr Glu Leu Ser Wing Arg His Glu Ala Ala Lys Gln Thr 305 310 315 320 Leu Ala Arg Val Ser Asp Leu Leu Val Ala Ala Gln Ser Glu Glu Thr 325 330 335 • Val Ala Ser Met Asn Leu Lys Arg Ala Glu Thr Glu Leu Lys Arg Leu 340 345 350 Glu Ser Leu Pro Val Ala Glu Val Ser Glu Glu He Ala Arg Glu Val 20 355 360 365 Glu Lys Leu Phe Leu Wing Asn Thr Arg Arg Val His Wing Wing Asn Val 370 375 380 Asp Glu Gln Thr He Wing Wing Leu Arg Glu Asp Leu Asp Lys Gln He Asp 385 390 395 400 Wing Asn Glu Wing Glu Leu Arg Arg Cys Glu Asn Gln He Val Gly He 405 410 415 Leu Arg Ser Tyr He Glu Thr Trp Pro Wing Asn Arg Wing Asp Leu Gln 420 425 430 Wing Glu Pro Glu Phe Val Gly Glu Wing He Asn Arg Leu Gly Glu Leu 435 440 445 Arg Ser Asp Arg Leu Wing Glu Phe Thr Wing Lys Phe Leu Gly Leu Met 25 450 455 460 Asn Glu Met Ser Thr Arg Asn Leu Gly Gln Be Arg Arg Leu Arg 465 470 475 480 Asp Wing Arg Arg Glu He Glu Glu Arg He Glu Pro He Asn Wing Ser 485 490 495 Leu Wing Gln Ser Glu Phe Asn Glu Gly Arg Phe Leu His He Asp He 500 505 510 Arg Asp Gln Ser Gly Pro He Val Arg Glu Phe Gln GIn Lys Leu Asp 515 520 525 Wing Wing Thr Ser Gly Asp Leu Gly Thr Ser Thr Glu Lys Gln Wing Phe 530 535 540 Ala Arg Tyr Ala Leu He Ala Glu He He Ser Lys Leu Ala Ser His 545 550 555 560 Asp Ser Wing Asp Wing Arg Trp Arg Asn Thr Val Leu Asp Thr Arg Arg 565 570 575 His Val Arg Phe He Gly Leu Glu Arg Asp Ser Asp Gly Wing Thr Val 580 585 590 Asn Thr Tyr Val Asp Ser Wing Ser Leu Ser Gly Gly Gln Wing Gln Lys 595 600 605 Leu Val Phe Phe Cys Leu Wing Wing Wing Leu Arg Tyr Gln Leu Wing Glu 610 615 620 Pro Gly Wing His Tyr Pro Thr Tyr Wing Thr Val He Leu Asp Glu Wing 625 630 635 640 Phe Asp Arg Wing Asp Pro Wing Phe Thr Arg Gln Thr Met Asn Val Phe 645 650 655 His Ser Phe Gly Phe His Met Val Leu Wing Thr Pro Leu Lys Leu He 660 665 670 Gln Thr Leu Gly Asp Tyr Val Gly Ser Thr He Val Val Ser Tyr Thr 675 680 685 Glu Lys Pro Asn Wing Gln Gly Wing He Gln Gly Asn Being Ser Phe Ser 690 695 700 Arg He Glu Lys 705 < 210 > 315 < 211 > 1152 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1129) < 223 > RXN02571 < 400 > 315 tggacaggcc ggggcegegt acggtgttgg ttgaggtggt ggaggggcgc gtcgaaaagc 60 attgtcgctg gttgttgccg cttttggcag tcgggatggc gtg gtg gct cct act 115 Val Val Ala Leu Thr 1 5 ca t ate gtc gga ccg tcc ggc tcc ggg etc acg cgg gaa ttg gaa aaa 163 Gln He Val Gly Pro Ser Gly Ser Gly Leu Thr Arg Glu Leu Glu Lys 10 15 20 cgc tac cgg gaa acg ccc gga gcg gtg atg ctg acc gcc gac ccg cgc 211 Arg Tyr Arg Glu Thr Pro Gly Ala Val Met Leu Thr Wing Asp Pro Arg 25 30 35 gcg cat ate acc tac ctg cgc gcg here gtc gcc gag gag ctg gcc ttt 259 Wing His He Thr Tyr Leu Arg Wing Thr Val Wing Glu Glu Leu Wing Phe 40 45 50 -iitii ggg ctg gaa cag cgc ggc ate gta ccc gcg cag atg tgg gag cgc gtc 307 Gly Leu Glu Gln Arg Gly He Val Pro Wing Gln Met Trp Glu Arg Val 55 60 65 cga aac ate ggg etc ggc etc gag aat ctg cta gac cgc gca ccc gcg 355 Arg Asn He Gly Leu Gly Leu Glu Asn Leu Leu Asp Arg Ala Pro Wing 70 75 80 85 caá ctt tcc ggc ggg ca gà cgg cgg gcg gcg gcc acc gtc gcc 403 Gln Leu Ser Gly Gly Gln Thr Arg Arg Leu Wing He Gly Thr Val Wing 90 95 100 ate tta gag gcg cca acg atg ctt etc gac gac ccc etc tcc ggt ctt 451 He Leu Glu Wing Pro Thr Met Leu Leu Asp Asp Pro Leu Ser Gly Leu 105 110 115 gat acc tcc tcg cg cg gcc cat etc ttg gtc gtc gtc gtc ate gtc gct gcg falls aag cgg tgg etc gac gcg ccg act 547 Gly Asp Val He Val Wing Wing His Lys Arg Trp Leu Asp Wing Pro Thr 135 140 145 gtg tac tta ggg gat ttg gag gag ctg tcc ctg ect gcg cgg gtg gaa 595 Val Tyr Leu Gly Asp Leu Glu Glu Leu Ser Leu Pro Wing Arg Val Glu 150 155 160 165 10 ttt tcc ggt cca tcg cga acg ttt tea gcg att here gga acc cgc gga 643 Phe Ser Gly Pro Ser Arg Thr Phe Ser Ala He Thr Gly Thr Arg Gly 170 175 180 • caá cag cgc cga cgc tgg tgg cat ttc aac gaa tcc ca cca cag ttt 691 Gln Gln Arg Arg Trp Trp Gln Phe Asn Glu Ser Gln Pro Gln Phe 185 190 195 cag ate ggc ccc ctg gat att act gtt tet gca ggt ca gtg ctg tgg 739 Gln He Gly Pro Leu Asp He Thr Val Be Wing Gly Gln Val Leu Trp 200 205 210 ttg cag ggt ccc aat ggt tea ggg aag tcc here etc ctg cgt ggt ctt 787 Leu Gln Gly Pro Asn Gly Ser Gly Lys Ser T hr Leu Leu Arg Gly Leu 15 215 220 225 gcc aat gaa ccc ggc act gaa ttg atg ctg cat aac ect age gat ca g 835 Wing Asn Glu Pro Gly Thr Glu Leu Met Leu Gln Asn Pro Ser Asp Gln 230 235 240 245 gtc att gac tcc act gtt gct aat tgg gtg cca ggc agt aac agt gaa 883 Val He Asp Ser Thr Val Wing Asn Trp Val Pro Gly Ser Asn Ser Glu 250 255 260 gaa cat ccg ctg gat tta tcg cac cgc gaa etc cgc ctt gcc cac tgc 931 Glu His Pro Leu Asp Leu Ser Gln Arg Glu Leu Arg Leu Wing Gln Cys • 265 270 275 gac gca gcc ctg ggt aat aac ccg gaa gtt ttg ctt gct gat gaa ccc 979 Asp Ala Ala Leu Gly Asn Asn Pro Glu Val Leu Leu Ala Asp Glu Pro 20 280 285 290 gac gtc ggc ctt gat gtc ggc ggt cga aac gcc ate drops cag cgc ttt 1027 Asp Val Gly Leu Asp Val Gly Gly Arg Asn Ala He His Gln Arg Phe 295 300 305 gcg gat ttc tta ggg aat ggg gga gcg ctg ate ctg acc tgc cat gat 1075 Wing Asp Phe Leu Gly Asn Gly Gly Wing Leu He Leu Thr Cys His Asp 310 315 320 325 gaa acc ttc gtg gca gag gta gct gaa tac gcg ata gtg aag gaa atg 11 23 Glu Thr Phe Val Ala Glu Val Ala Glu Tyr Ala He Val Lys Glu Met 330 335 340 ggg etc taggtttctt tggaccaaac drops 1152 Gly Leu 25 < 210 > 316 < 211 > 343 < 212 > PRT < 213 > CoryneDacterium glutamicum < 400 > 316 Val Val Ala Leu Thr Gln He Val Gly Pro Ser Gly Ser Gly Leu Thr 1 5 10 15 Arg Glu Leu Glu Lys Arg Tyr Arg Glu Thr Pro Gly Wing Val Met Leu 20 25 30 Thr Wing Asp Pro Arg Wing His He Thr Tyr Leu Arg Wing Thr Val Wing 35 40 45 Glu Glu Leu Wing Phe Gly Leu Glu Gln Arg Gly He Val Pro Ala Gln 50 55 60 Met Trp Glu Arg Val Arg Asn He Gly Leu Gly Leu Glu Asn Leu Leu 65 70 75 80 Asp Arg Ala Pro Ala Gln Leu Ser Gly Gly Gln Thr Arg Arg Leu Ala 85 90 95 He Gly Thr Val Wing He Leu Glu Wing Pro Thr Met Leu Leu Asp Asp 100 105 110 Pro Leu Ser Gly Leu Asp Thr Ser Ser Arg Ala Gln Leu He Thr Met 115 120 125 Leu Glu Ser Tyr Glu Gly Asp Val He Val Wing Ala His Lys Arg Trp 130 135 140 Leu Asp Ala Pro Thr Val Tyr Leu Gly Asp Leu Glu Glu Leu Ser Leu 145 150 155 160 Pro Ala Arg Val Glu Phe Ser Gly Pro Ser Arg Thr Phe Ser Ala He 165 170 175 Thr Gly Thr Arg Gly Gln Gln Arg Arg Arg Trp Trp Gln Phe Asn Glu 180 185 190 Ser Gln Pro Gln Phe Gln He Gly Pro Leu Asp He Thr Val Ser Wing 195 200 205 Gly Gln Val Leu Trp Leu Gln Gly Pro Asn Gly Ser Gly Lys Ser Thr 210 215 220 Leu Leu Arg Gly Leu Wing Asn Glu Pro Gly Thr Glu Leu Met Leu Gln 225 230 235 240 Asn Pro As Asp Gln Val As Asp Ser Thr Val Asn Asp Trp Val Pro 245 250 255 Gly Ser Asn Ser Glu Glu His Pro Leu Asp Leu Ser Gln Arg Glu Leu 260 265 270 Arg Leu Wing Gln Cys Asp Wing Wing Leu Gly Asn Asn Pro Glu Val Leu 275 280 285 Leu Wing Asp Glu Pro Asp Val Gly Leu Asp Val Gly Gly Arg Asn Wing 290 295 300 He His Gln Arg Phe Wing Asp Phe Leu Gly Asn Gly Gly Wing Leu He 305 310 315 320 Leu Thr Cys His Asp Glu Thr Phe Val Wing Glu Val Wing Glu Tyr Ala 325 330 335 He Val Lys Glu Met Gly Leu 340 < 210 > 317 < 211 > 1152 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1129) < 223 > FRXA02571 < 400 > 317 tggacaggcc ggggccg gt acggtgttgg ttgaggtggt g a > ggggcgc gtcg, aaaagc 60 attgtcgctg gttgttgccg cttttggcag tcgggatggc gtg gtg gct cta act 115 5 Val Val Ala Leu Thr • 1 5 ca ate ate gtc gga ccg tcc ggc tcc ggg etc acg cgg gaa ttg gaa aaa 163 Gln He Val Gly Pro Ser Gly Ser Gly Leu Thr Arg Glu Leu Glu Lys 10 15 20 cgc tac cgg gaa acg ccc gga gcg gtg atg ctg acc gcc gac ccg cgc 211 Arg Tyr Arg Glu Thr Pro Gly Wing Val Met Leu Thr Wing Asp Pro Arg 25 30 35 gcg cat ate acc tac cgc gcg gtc here gcc gag gag ctg gcc ttt 259 Ala His He Thr Tyr Leu Arg Wing Thr Val Wing Glu Glu Leu Wing Phe 40 45 50 ggg ctg gaa cac cgc ggc ate gta ccc gcg cag atg tgg gag cgc gtc 307 ío G1v Leu Glu Gln Arg Gly He Val Pro Ala Gln Met Trp Glu Arg Val 55 60 65 cga aac ate ggg etc ggc etc gag aat ctg cta gac cgc gca ccc gcg 355 Arg Asn He Gly Leu Gly Leu Glu Asn Leu Leu Asp Arg Ala Pro Wing • 70 75 80 85 caá ctt tcc ggc ggg caá here cgg cgg ctg gcg ate ggc acc gtc gcc 403 Gln Leu Be Gly Gly Gln Thr Arg Arg Leu Wing He Gly Thr Val Wing 90 95 100 ate tta gag gcg cca acg atg ctt etc gac gac ccc etc tcc ggt ctt 451 He Leu Glu Ala Pro Thr Met Leu Leu Asp Asp Pro Leu Ser Gly Leu 105 110 115 gat acc tcc tcg cga gcc caa etc tie here atg ttg gaa tea tat gag 499 15 AsP Thr Ser Ser Arg Ala Gln Leu He Thr Met Leu Glu Ser Tyr Glu 120 125 130 ggc gat gtc ate gtc gct gcg falls aag cgg tgg etc gac gcg ccg act 547 Gly Asp Val He Val Wing Wing His Lys Arg Trp Leu Asp Wing Pro Thr 135 140 145 gtg tac tta ggg gat ttg gag gag ctg tcc ctg ect gcg cgg gtg gaa 595 Val Tyr Leu Gly Asp Leu Glu Glu Leu Ser Leu Pro Wing Arg Val Glu 150 155 160 165 ttt tc ggt cca tcg cga acg ttt tea gcg att here gga acc cgc gga 643 Phe Ser Gly Pro Be Arg Thr Phe Be Wing He Thr Gly Thr Arg Gly 170 175 180 caá cag cgc cga cgc tgg tgg ca t tc aac gaa tcc ca c cca cag ttt 691 20 Gln Gln Arg Arg Arg Trp Trp Gln Phe Asn Glu Ser Gln Pro Gln Phe 185 190 195 cag ate ggc ccc ctg gat att act gtt tet gca ggt ca gtg ctg tgg 739 Gln He Gly Pro Leu Asp He Thr Val Ser Wing Gly Gln Val Leu Trp 200 205 210 ttg cag ggt ccc aat ggt tea ggg aag tcc here etc ctg cgt ggt ctt 787 Leu Gln Gly Pro Asn Gly Be Gly Lys Ser Thr Leu Leu Arg Gly Leu 215 220 225 gcc aat gaa ccc ggc act gaa ttg atg ctg ca a aac ect age gat ca g 835 Wing Asn Glu Pro Gly Thr Glu Leu Met Leu Gln Asn Pro Ser Asp Gln 230 235 240 245 gtc att gac tcc act gtt gct aat tgg gtg cca ggc agt aac agt gaa 883 25 Val He Asp Ser Thr Val Wing Asn Trp Val Pro Gly Ser Asn Ser Glu 250 255 260 gaa cat ccg ctg gat tta tcg caa cgc gaa etc cgc ctt gcc ca tgc 931 Glu His Pro Leu Asp Leu Ser Gln Arg Glu Leu Arg Leu Wing Gln Cys 265 270 275 gac gca gcc ctg ggt aat aac ccg gaa gtt ttg ctt gct gat gaa ccc 979 Asp Ala Ala Leu Gly Asn Asn Pro Glu Val Leu Leu Ala Asp Glu Pro 280 285 290 gac gtc ggc ctt gat gtc ggc ggt cga aac gcc ate drops cag cgc ttt 1027 Asp Val Gly Leu Asp Val Gly Gly Arg Asn Ala He His Gln Arg Phe • 295 300 305 gcg gat ttc tta ggg aat ggg gga gcg ctg ate ctg acc tgc cat gat 1075 Wing Asp Phe Leu Gly Asn Gly Gly Wing Leu He Leu Thr Cys His Asp 310 315 320 325 gaa acc ttc gtg gca gag gta gct gaa tac gcg ata gtg aag gaa atg 1123 Glu Thr Phe Val Wing Glu Val Wing Glu Tyr Wing He Val Lys Glu Met 330 335 340 ggg etc taggtttctt tggaccaaac drops 1152 Gly Leu 10 < 210 > 318 < 211 > 343 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 318 Val Val Ala Leu Thr Gln He Val Gly Pro Ser Gly Ser Gly Leu Thr 1 5 10 15 Arg Glu Leu Glu Lys Arg Tyr Arg Glu Thr Pro Gly Wing Val Met Leu 20 25 30 Thr Wing Asp Pro Arg Wing His He Thr Tyr Leu Arg Wing Thr Val Wing 35 40 45 15 Glu Glu Leu Wing Phe Gly Leu Glu Gln Arg Gly He Val Pro Wing Gln 50 55 60 Met Trp Glu Arg Val Arg Asn He Gly Leu Gly Leu Glu Asn Leu Leu 65 70 75 80 Asp Arg Ala Pro Ala Gln Leu Ser Gly Gly Gln Thr Arg Arg Leu Wing 85 90 95 He Gly Thr Val Wing He Leu Glu Wing Pro Thr Met Leu Leu Asp Asp 100 105 110 Pro Leu Ser Gly Leu Asp Thr Ser Ser Arg Ala Gln Leu He Thr Met 115 120 125 Leu Glu Ser Tyr Glu Gly Asp Val He Val Wing Wing His Lys Arg Trp 130 135 140 20 Leu Asp Ala Pro Thr Val Tyr Leu Gly Asp Leu Glu Glu Leu Ser Leu 145 150 155 160 Pro Ala Arg Val Glu Phe Ser Gly Pro Be Arg Thr Phe Be Wing He 165 170 175 Thr Gly Thr Arg Gly Gln Gln Arg Arg Arg Trp Trp Gln Phe Asn Glu 180 185 190 Ser Gln Pro Gln Phe Gln He Gly Pro Leu Asp He Thr Val Ser Wing 195 200 2 05 Gly Gln Val Leu Trp Leu Gln Gly Pro Asn Gly Ser Gly Lys Ser Thr 210 215 220 Leu Leu Arg Gly Leu Wing Asn Glu Pro Gly Thr Glu Leu Met Leu Gln 225 230 235 240 25 Asn Pro As Asp Gln Val He Asp Ser Thr Val Wing Asn Trp Val Pro 245 250 255 Gly Ser Asn Ser Glu Glu His Pro Leu Asp Leu Ser Gln Arg Glu Leu 260 265 270 Arg Leu Ala Gln Cys Asp Ala Ala Leu Gly Asn Asn Pro Glu Val Leu 275 280 285 Leu Ala Asp Glu Pro Asp Val Gly Leu Asp Val Gly Gly Arg Asn Ala 290 295 300 He His Gln Arg Phe Wing Asp Phe Leu Gly Asn Gly Gly Wing Leu He 305 310 315 320 • Leu Thr Cys His Asp Glu Thr Phe Val Wing Glu Val Ala Glu Tyr Ala 325 330 335 He Val Lys Glu Met Gly Leu 340 < 210 > 319 < 211 > 1746 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > 10 < 221 > CDS < 222 > (101) .. (1723) < 223 > RXN02074 • < 400 > 319 cgggggaagg < ocgtgtcgica tgctcigggct agt? cttggat etcaaga; aga; attctgactgg 60 ttt; aaagtct igggctttaag ttgcagaaagg ttgtggattg atg cgc tcc ctg ctt 115 Met Arg Ser Leu Leu 1 5 cgt gat ate ect gcg gtg ggt tgg cta ate acc gcg acg att gtt gtg 163 Arg Asp He Pro Wing Val Gly Trp Leu He Thr Wing Thr He Val Val 10 15 20 acg etc gtt gtt gcg ctg gtc ate gtt ggg ate ggc ttg ctt ate 211 15 A9rgC Thr Leu Val Val Ala Leu Val He Val Gly He Gly Leu Leu He 25 30 35 gac gtc ccc tcg ccc gct cat tea gcc atg ttg tgg tgg gtt ctg gca 259 Asp Val Pro Ser Pro Wing His Ser Wing Met Leu Trp Trp Val Leu Wing 40 45 50 ggt gcc acg gca gca gcg ctg ctg tgc gcg gaa gcg gtg etc ccc 307 Gly Wing Thr Wing Wing Wing Wing Leu Leu Cys Wing Glu Wing Val Leu Pro 55 60 65 • cag cgt att cgt gca cga gtt gaa cga tcc tgg cgg cgg cag ttg gct 355 Gln Arg He Arg Ala Arg Val Glu Arg Ser Trp Arg Arg Gln Leu Wing 70 75 80 85 20 gct aaa aat ctg gag ctg aat tcc agt tcg tea gat gat gcc cag ttg 403 U Wing Lys Asn Leu Glu Leu Asn Being Being Being Asp Asp Wing Gln Leu 90 95 100 ate here ctg gca act gaa gcc acc aaa gca tcc act tac here gtg 451 He Thr Leu Wing Thr Glu Wing Thr Ser Lys Wing Being Thr Tyr Thr Val 105 110 115 atg ttt ctg ggg ect tac ttt gca gta ttt ttg gcc cca ctg here gtt 499 Met Phe Leu Gly Pro Tyr Phe Wing Val Phe Leu Wing Pro Leu Thr Val 120 125 130 att gcc gtt gtc ggc gcg gct att tcc tgg ccg att gcg ggg ata ctg 547 He Ala Val Val Gly Ala Ala He Ser Trp Pro He Wing Gly He Leu 135 140 145, tgc etc ggg ttg tgc gtg ata ect ttc gtt att tet tgg gca cag cgc 595 Ha ^^ bi__li Cys Leu Gly Leu Cys Val He Pro Phe Val He Ser Trp Wing Gln Arg 150 155 160 165 atg ttg aaa ggc gct ggc gcg gga tac ggg cga gca tet ggg cag ttg 643 Met Leu Lys Gly Wing Gly Wing Gly Tyr Gly Arg Wing Being Gly Gln Leu 170 175 180 gca ggc gtg ttt ttg gaa tcg gtg cgc here cta ggc acc acg atg atg 691 Wing Gly Val Phe Leu Glu Ser Val Arg Thr Leu Gly Thr Met Met 185 190 195 ctg aat gcc ggg gg cag cgc agg cag ate ate cgc ca gc gg gag 739 Leu Asn Ala Ala Gly Gln Arg Arg Gln He He Thr Gln Arg Ala Glu 200 205 210 aat atg cgc tcc ca gtg atg tea ttg ctg tac cga aat cag ttg atg 787 Asn Met Arg Ser Gln Val Met Ser Leu Leu Tyr Arg Asn Gln Leu Met 215 220 225 att ctg gtg gcg gtg gtg ttt gtt gtt gcc acc atg gtt gct 835 He Leu Val Thr Asp Gly Val Phe Gly Val Ala Thr Thr Met Val Ala 230 235 240 245 gcg gtg ttt gcc att gga gga ttc ttt tea ggc tet ctt act etc ggc 883 Wing Val Phe Wing He Gly Gly Phe Phe Ser Gly Ser Leu Thr Leu Gly 250 255 260 10 ca gct gta gc gta etc gta ttg ctg gcc agg ctg ctt att gat ccc ate 931 Gln Ala Val Ala Leu Val Leu Leu Ala Arg Leu Leu He Asp Pro He 265 270 275 aac cgc atg ggt cgc acg ttt tac acc ggc atg gca ggc aaa ccc tcg 979 • Asn Arg Met Gly Arg Thr Phe Tyr Thr Gly Met Wing Gly Lys Pro Ser 280 285 290 ctg ate gcc att gaa aaa gcc etc gcg here acc ttt act gat cag cca 1027 Leu He Wing He Glu Lys Wing Leu Wing Thr Thr Phe Thr Asp Gln Pro 295 300 305 act ca gg cag cag cgc falls gat ggg gat ctg gtg gtc aac aac ttg 1075 Thr Gln Gln Gly Gln Arg His Asp Gly Asp Leu Val Val Asn Asn Leu 310 315 320 325 15 aag ate gcc cgc gat falls agg gac att gtg falls ggt ate tet ttc age 1123 Lys He Wing Arg Asp His Arg Asp He Val His Gly He Ser Phe Ser 330 335 340 Att ccc cgc ggt tcc falls at gcg gtg gta gta gcc cct agt ggc gct ggt 1171 He Pro Arg Gly Ser His He Wing Val Val Gly Pro Ser Gly Wing Gly 345 350 355 aaa tcc tet gtg gct cta gcg ttg tcc gga ctt tta gag ttt gat ggt 1219 Lys Ser Ser Val Ala Leu Ala Leu Ser Gly Leu Leu Glu Phe Asp Gly • 360 365 370 gcg att tcc etc ggc ggc falls aac tgt gag atg tta gat ctt cgc gcc 1267 Ala He Ser Leu Gly Gly His Asn Cys Glu Met Leu Asp Leu Arg Wing 375 380 385 20 tea gtc agt ttc gtg ccc cacc tcc ccc acg ctg ttt age gga age ate 1315 Ser Val Val Phe Pro Gln Ser Pro Thr Leu Phe Ser Gly Ser He 390 395 400 405 aaa age aat ate gat ctg gcg cgc acg ggt gtt gat tet gat cae ate 1363 Lys Ser Asn He Asp Leu Wing Arg Thr Gly Val Asp Ser Asp His He 410 415 420 falls gca gca ctt tta ggc gaa gaa etc ccc gcg gac etc aaa gtc ggt 1411 His Wing Wing Leu Leu Gly Glu Glu Leu Pro Wing Asp Leu Lys Val Gly 425 430 435 gaa acc ggc aaa ggt gtc tcc ggc ggc ca gca gca cgc att tcc att 1459 Glu Thr Gly Lys Gly Val Ser Gly Gly Gln Wing Wing Arg He Ser He 440 445 450 25 gcc cg ggt tta gta aag aat gct gcc gtg att gtt etc gac gag gcg 1507 Wing Arg Gly Leu Val Lys Asn Ala Wing Val He Val Leu Asp Glu Wing 455 460 465 acc gca caa etc gac tac acc aac gcc cgc cag gtt cga cat ctt gcc 1555 Thr Wing Gln Leu Asp Tyr Thr Asn Wing Arg Gln Val Arg His Leu Wing 470 475 480 485 aaa tcc ctt gag tgc acg ttg gtt gag ate acc fall cgc cca tea gaa 1603 Lys Ser Leu Glu Cys Thr Leu Val Glu He Thr His Arg Pro Ser Glu 490 495 500 gcc etc gat gca gac ttc ate att gtt tta gag gat ggc cat ttg acc 1651 Ala Leu Asp Ala Asp Phe He He Val Leu Glu Asp Gly Gln Leu Thr 505 510 515 atg atg gat ccc age aac gtt tcc cag cae aat gcg ttt tcc cgc 1699 Met Met Asp Thr Pro Ser Asn Val Ser Gln His Asn Ala Phe Phe Arg 520 525 530 acc gct gtg atg gag gaa gaa ca t tttttccg acttctccaa ttg 1746 Thr Wing Val Met Glu Glu Glu Gln 535 540 < 210 > 320 < 211 > 541 10 < 212 > PRT < 213 > Corynebacterium glutamicum • < 400 > 320 Met Arg Ser Leu Leu Arg Asp He Pro Wing Val Gly Trp Leu He Thr 1 5 10 15 Wing Thr He Val Val Arg Thr Leu Val Val Wing Leu Val He Val Gly 20 25 30 He Gly Leu Leu He Asp Val Pro Pro Pro Ala His Ser Ala Met Leu 35 40 45 Trp Trp Val Leu Ala Gly Ala Thr Ala Ala Ala Ala Leu Leu Cys Wing 50 55 60 15 Glu Wing Val Leu Pro Gln Arg He Arg Wing Arg Val Glu Arg Ser Trp 65 70 75 80 Arg Arg Gln Leu Wing Wing Lys Asn Leu Glu Leu Asn Being Ser Being 85 90 95 Asp Asp Wing Gln Leu He Thr Leu Wing Thr Glu Wing Thr Ser Lys Wing 100 105 110 Ser Thr Tyr Thr Val Met Phe Leu Gly Pro Tyr Phe Wing Val Phe Leu 115 120 125 • Wing Pro Leu Thr Val He Wing Val Val Gly Wing Wing He Ser Trp Pro 130 135 140 He Wing Gly He Leu Cys Leu Gly Leu Cys Val He Pro Phe Val He 145 150 155 160 20 Ser Trp Wing Gln Arg Met Leu Lys Gly Wing Gly Wing Gly Tyr Gly Arg 165 170 175 Wing Ser Gly Gln Leu Wing Gly Val Phe Leu Glu Ser Val Arg Thr Leu 180 185 190 Gly Thr Thr Met Met Leu Asn Wing Wing Gly Gln Arg Arg Gln He He 195 200 205 Thr Gln Arg Wing Glu Asn Met Arg Ser Gln Val Met Ser Leu Leu Tyr 210 215 220 Arg Asn Gln Leu Met He Leu Val Thr Asp Gly Val Phe Gly Val Wing 225 230 235 240 Thr Thr Met Val Wing Wing Val Phe Wing He Gly Gly Phe Phe Ser Gly 245 250 255 25 Ser Leu Thr Leu Gly Gln Wing Val Ala Leu Val Leu Leu Ala Arg Leu ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ 265 270 Leu He Asp Pro He Asn Arg Met Gly Arg Thr Phe Tyr Thr Gly Met 275 280 285 Wing Gly Lys Pro Ser Leu He Wing He Glu Lys Wing Leu Wing Thr Thr 290 295 300 Phe Thr Asp Gln Pro Thr Gln Gln Gly Gln Arg His Asp Gly Asp Leu 305 310 315 320 Val Val Asn Asn Leu Lys He Wing Arg Asp His Arg Asp He Val His 325 330 335 Gly He Ser Phe Ser He Pro Arg Gly Ser His He Wing Val Val Gly 340 345 350 Pro Ser Gly Wing Gly Lys Ser Ser Val Ala Leu Wing Leu Ser Gly Leu 355 360 365 Leu Glu Phe Asp Gly Wing He Ser Leu Gly Gly His Asn Cys Glu Met 370 375 380 Leu Asp Leu Arg Ala Ser Val Ser Phe Val Pro Gln Ser Pro Thr Leu 385 390 395 400 Phe Ser Gly Ser He Lys Ser Asn He Asp Leu Wing Arg Thr Gly Val 405 410 415 Asp Ser Asp His He His Wing Wing Leu Leu Gly Glu Glu Leu Pro Wing 420 425 430 Asp Leu Lys Val Gly Glu Thr Gly Lys Gly Val Ser Gly Gly Gln Wing 435 440 445 Wing Arg He Ser Wing Wing Arg Gly Leu Val Lys Asn Wing Wing Val He 450 455 460 Val Leu Asp Glu Wing Thr Wing Gln Leu Asp Tyr Thr Asn Wing Arg Gln 465 470 475 480 Val Arg His Leu Wing Lys Ser Leu Glu Cys Thr Leu Val Glu He Thr 485 490 495 His Arg Pro Ser Glu Ala Leu Asp Wing Asp Phe He He Val Leu Glu 500 505 510 Asp Gly Gln Leu Thr Met Met Asp Thr Pro Ser Asn Val Ser Gln His 515 520 525 Asn Wing Phe Phe Arg Thr Wing Val Met Glu Glu Glu Gln 530 535 540 < 210 > 321 < 211 > 1746 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1723) < 223 > FRXA02074 < 400 > 321 cgggggaagg ccgtgtcgca tgctcgggct agccttggat etcaagaaga attcgactgg 60 tttaaagtct gggctttaag tgcagaaagg ttgtggattg atg cgc tcc ctg ctt 115 Met Arg Ser Leu Leu 1 5 cgt gat ate ect gcg gtg ggt tgg cta ate acc gcg acg att gtt gtg 163 Arg Asp He Pro Wing Val Gly Trp Leu He Thr Wing Thr He Val Val 10 15 20 cgc acg etc gtt gtt gcg ctg gtc ate gtt ggg ate ggc ttg ctt ate 211 Arg Thr Leu Val Val Ala Leu Val He Val Gly He Gly Leu Leu He 25 30 35 gac gtc ccc tcg ccc gct cat tea gcc atg ttg tgg tgg gtt ctg gca 259 Asp Val Pro Ser Pro Wing His Ser Wing Met Leu Trp Trp Val Leu Wing 40 45 50 ggt gcc acg gca gca gcg ctg ctg tgc gcg gaa gcg gtg etc ccc 307 Gly Ala Thr Ala Ala Ala Ala Leu Leu Cys Ala Glu Ala Val Leu Pro 55 60 65 caà cgt att cgt gca cga gtt gaa cga tcc tgg cgg cgg cag ttg gct 355 Gln Arg He Arg Wing Arg Val Glu Arg Ser Trp Arg Arg Gln Leu Ala 70 75 80 85 gct aaa aat ctg gag ctg aat tcc agt tcg tea gat gat gcc cag ttg 403 Wing Lys Asn Leu Glu Leu Asn Being Being Ser Asp Asp Wing Gln Leu 90 95 100 ate here gt act gt gcc acc aa aaa gca tcc act tac gtg 451 He Thr Leu Wing Thr Glu Wing Thr Ser Lys Wing Being Thr Tyr Thr Val 105 110 115 atg ttt ctg ggg ect tac ttt gca gta ttt ttg gcc cca ctg here gtt 499 Met Phe Leu Gly Pro Tyr Phe Wing Val Phe Leu Wing Pro Leu Thr Val 120 125 130 att gcc gtt gtc ggc gcg gct att tcc tgg ccg att gcg ggg ata ctg 547 He Wing Val Val Gly Ala Wing He Ser Trp Pro He Wing Gly He Leu 135 140 145 tgc etc ggg ttg tgc gtg ata ect ttc gtt att tet tgg gca cag cgc 595 Cys Leu Gly Leu Cys Val He Pro Phe Val He Ser Trp Wing Gln Arg 150 155 160 165 atg ttg aaa ggc gct ggc gcg gga tac ggg cga gca tet ggg cag ttg 643 Met Leu Lys Gly Wing Gly Wing Gly Tyr Gly Arg Wing Being Gly Gln Leu 170 175 180 gca ggc gtg ttt ttg gaa tcg gtg cgc here cta ggc acc acg atg atg 691 Wing Gly Val Phe Leu Glu Ser Val Arg Thr Leu Gly Thr Met Met 185 190 195 ctg aat gcc ggg gg cag cgc agg cag ate ate cgc ca gc gg gag 739 Leu Asn Ala Ala Gly Gln Arg Arg Gln He He Thr Gln Arg Ala Glu 200 205 210 aat atg cgc tcc ca gtg atg tea ttg ctg tac cga aat cag ttg atg 787 Asn Met Arg Ser Gln Val Met Ser Leu Leu Tyr Arg Asn Gln Leu Met 215 220 225 att ctg gtg acc gcg gtg gtt gtt gtt gtt gcc gt acc gt gtg gtg 835 He Leu Val Thr Asp Gly Val Phe Gly Val Wing Thr Thr Met Val Wing 230 235 240 245 gcg gtg ttt gcc att gga gga ttc ttt tea ggc tet ctt act etc ggc 883 Wing Val Phe Wing He Gly Gly Phe Phe Ser Gly Ser Leu Thr Leu Gly 250 255 260 ca gct gta gc gta etc gta ttg ctg gcc agg ctg ctt att gat ccc ate 931 Gln Ala Val Ala Leu Val Leu Leu Ala Arg Leu Leu He Asp Pro He 265 270 275 aac cgc atg ggt cgc acg ttt tac acc ggc atg gca ggc aaa ccc tcg 979 Asn Ar'g Met Gly Arg Thr Phe Tyr Thr Gly Met Wing Gly Lys Pro Ser 280 285 290 ctg ate gcc att gaa aaa gcc etc gcg here acc ttt act gat cag cca 1027 Leu He Wing He Glu Lys Wing Leu Wing Thr Thr Phe Thr Asp Gln Pro 295 300 305 act ca gg cag cag cgc falls gat ggg gat ctg gtg gtc aac aac ttg 1075 Thr Gln Gln Gly Gln Arg His Asp Gly Asp Leu Val Val Asn Asn Leu 310 315 320 325 aag ate gcc cgc gat falls agg gac att gtg falls ggt ate tet ttc age 1123 Lys He Wing Arg Asp His Arg Asp He Val His Gly He Ser Phe Ser 330 335 340 The t. i tí, att ccc cgc ggt tcc falls ate gcg gtg gta ggt ccc agt ggc gct ggt 1171 He Pro Arg Gly Ser His He Wing Val Val Gly Pro Ser Gly Wing Gly 345 350 355 aaa tcc tet gtg gct cta gcg ttg tcc gga ctt tta gag ttt gat ggt 1219 Lys Ser Ser Val Ala Leu Ala Leu Ser Gly Leu Leu Glu Phe Asp Gly 360 365 370 gcg tcc att ggc ggc falls aac tgt gag atg tta gat ctt cgc gcc 1267 Ala He Ser Leu Gly Gly His Asn Cys Glu Met Leu Asp Leu Arg Ala 375 380 385 tea gtc agt ttc gtg ccc cacc tcc ccc acg ctg ttt age gga age ate 1315 Ser Val Val Phe Pro Gln Ser Pro Thr Leu Phe Ser Gly Ser He 390 395 400 405 aaa age aat ate gat ctg gcg cgc acg ggt gtt gat tet gat cae ate 1363 Lys Ser Asn He Asp Leu Wing Arg Thr Gly Val Asp Ser Asp His He 410 415 420 falls gca gca ctt tta ggc gaa gaa etc ccc gcg gac etc aaa gtc ggt 1411 His Wing Wing Leu Leu Gly Glu Glu Leu Pro Wing Asp Leu Lys Val Gly 425 430 435 gaa acc ggc aaa ggt gtc tcc ggc ggc ca gca gca cgc att tcc att 1459 Glu Thr Gly Lys Gly Val Ser Gly Gly Gln Wing Wing Arg He Ser He 440 445 450 10 gcc cg ggt tta gta aag aat gct gcc gtg att gtt etc gac gag gcg 1507 Wing Arg Gly Leu Val Lys Asn Wing Wing Val Heu Leu Asp Glu Wing 455 460 465 • acc gca caa etc gac tac acc aac gcc cgc cag gtt cga cat ctt gcc 1555 Thr Wing Gln Leu Asp Tyr Thr Asn Wing Arg Gln Val Arg His Leu Wing 470 475 480 485 aaa tcc ctt gag tgc acg ttg gtt gag ate acc fall cgc cca tea gaa 1603 Lys Ser Leu Glu Cys Thr Leu Val Glu He Thr His Arg Pro Ser Glu 490 495 500 gcc etc gat gca gac ttc ate att gtt tta gag gat ggc cat ttg acc 1651 Ala Leu Asp Ala Asp Phe He He Val Leu Glu Asp Gly Gln Leu Thr 505 510 515 15 atg atg gat ccc age aac gtt tcc cag cae aat gcg ttt tcc cgc 1699 Met Met Asp Thr Pro Ser Asn Val Ser Gln His Asn Ala Phe Phe Arg 520 525 530 acc gct gtg atg gag gaa caa tgatttcccg acttctccaa ttg 1746 Thr Ala Val Met Glu Glu Glu Gln 535 540 < 210 > 322 < 211 > 541 < 212 > PRT < 213 > Corynebact: erium glutamicum 20 < 400 > 322 Met Arg Ser Leu Leu Arg Asp He Pro Wing Val Gly Trp Leu He Thr 1 5 10 15 Wing Thr He Val Val Arg Thr Leu Val Val Wing Leu Val He Val Gly 20 25 30 He Gly Leu Leu He Asp Val Pro Pro Pro Ala His Ser Ala Met Leu 35 40 45 Trp Val Leu Ala Gly Ala Thr Ala Ala Ala Ala Leu Leu Cys Ala 50 55 60 Glu Ala Val Leu Pro Gln Arg He Arg Ala Arg Val Glu Arg Ser Trp 65 70 75 80 25 Arg Arg Gln Leu Ala Ala Lys Asn Leu Glu Leu Asn Being Being Being *,to_. ^ 85 90 95 Asp Asp Wing Gln Leu He Thr Leu Wing Thr Glu Wing Thr Ser Lys Wing 100 105 110 Ser Thr Tyr Thr Val Met Phe Leu Gly Pro Tyr Phe Wing Val Phe Leu 115 120 125 Wing Pro Leu Thr Val He Wing Val Val Gly Ala Ala He Ser Trp Pro 130 135 140 He Wing Gly He Leu Cys Leu Gly Leu Cys Val He Pro Phe Val He • 145 150 155 160 Be Trp Wing Gln Arg Met Leu Lys Gly Wing Gly Wing Gly Tyr Gly Arg 165 170 175 Wing Being Gly Gln Leu Wing Gly Val Phe Leu Glu Ser Val Arg Thr Leu 180 185 190 Gly Thr Thr Met Met Leu Asn Wing Wing Gly Gln Arg Arg Gln He He 195 200 205 Thr Gln Arg Ala Glu Asn Met Arg Ser Gln Val Met Ser Leu Leu Tyr 210 215 220 Arg Asn Gln Leu Met He Leu Val Thr Asp Gly Val Phe Gly Val Ala 225 230 235 240 Thr Thr Met Val Wing Wing Val Phe Wing He Gly Gly Phe Phe Ser Gly 10 245 250 255 Ser Leu Thr Leu Gly Gln Ala Val Ala Leu Val Leu Leu Ala Arg Leu 260 265 270 ^ Leu He Asp Pro He Asn Arg Met Gly Arg Thr Phe Tyr Thr Gly Met 275 280 285 Wing Gly Lys Pro Ser Leu He Wing He Glu Lys Wing Leu Wing Thr Thr 290 295 300 Phe Thr Asp Gln Pro Thr Gln Gln Gly Gln Arg His Asp Gly Asp Leu 305 310 315 320 Val Val Asn Asn Leu Lys He Wing Arg Asp His Arg Asp He Val His 325 330 335 Gly He Ser Phe Ser He Pro Arg Gly Ser His He Wing Val Val Gly 15 340 345 350 Pro Ser Gly Wing Gly Lys Ser Ser Val Wing Leu Wing Leu Ser Gly Leu 355 360 365 Leu Glu Phe Asp Gly Wing He Ser Leu Gly Gly His Asn Cys Glu Met 370 375 380 Leu Asp Leu Arg Ala Ser Val Ser Phe Val Pro Gln Ser Pro Thr Leu 385 390 395 400 Phe Ser Gly Ser He Lys Ser Asn He Asp Leu Wing Arg Thr Gly Val 405 410 415 Asp Ser Asp His He His Wing Wing Leu Leu Gly Glu Glu Leu Pro Wing 420 425 430 Asp Leu Lys Val Gly Glu Thr Gly Lys Gly Val Ser Gly Gly Gln Ala 20 435 440 445 Wing Arg He Ser Wing Wing Arg Gly Leu Val Lys Asn Wing Wing Val He 450 455 460 Val Leu Asp Glu Wing Thr Wing Gln Leu Asp Tyr Thr Asn Wing Arg Gln 465 470 475 480 Val Arg His Leu Wing Lys Ser Leu Glu Cys Thr Leu Val Glu He Thr 485 490 495 His Arg Pro Ser Glu Ala Leu Asp Wing Asp Phe He He Val Leu Glu 500 505 510 Asp Gly Gln Leu Thr Met Met Asp Thr Pro Ser Asn Val Ser Gln His 515 520 525 Asn Wing Phe Phe Arg Thr Wing Val Met Glu Glu Glu Gln 25 530 535 540 < 210 > 323 < 211 > 1527 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1504) < 223 > RXA02095 < 400 > 323 ctctcttggt icctc-tcccca cccattttt; a agtacticaag acccttccaa < Agagga 60 Tacticac Agagtacaga aaatactgaa aaaggatcacgc atg agaaga gagacaa 115 Met Lys Thr Glu Gln 1 5 tcc caa aaa gca cata tta gcc ect aag aaa gca ect gaa aag cca caa 163 Be Gln Lys Wing Gln Leu Wing Pro Lys Lys Wing Pro Glu Lys Pro Gln 10 15 20 cgc ate cgc ca ct att tcc gtg gcg tgg cag cga ect tgg etc acc 211 Arg He Arg Gln Leu He Ser Val Wing Trp Gln Arg Pro Trp Leu Thr 25 30 35 tea ttc acc gta ate age gct tta gct gca acg ttg ttt gaa ctt here 259 Be Phe Thr Val He Be Wing Leu Wing Wing Thr Leu Phe Glu Leu Thr 40 45 50 ctt ect ctt ttg acc ggt ggc gcc ate gat ate gcg etc gga aat acc 307 Leu Pro Leu Leu Thr Gly Gly Wing He Asp He Wing Leu Gly Asn Thr 55 60 65 gga gat act tta acc act gac ctg ctg gac cgg tcc act ccg agt gga 355 Gly Asp Thr Leu Thr Thr Asp Leu Leu Asp Arg Phe Thr Pro Ser Gly 70 75 80 85 tta age gtg ttg gtc att gcc ctt ate gtg ctt etc gcg ttg 403 Leu Ser Val Leu Thr Ser Val He Ala Leu He Val Leu Leu Ala Leu 90 95 100 ctt cgc tat gcc agt caa ttt gga cgg cga tac acc gca ggc aag etc 451 Leu Arg Tyr Wing Being Gln Phe Gly Arg Arg Tyr Thr Wing Gly Lys Leu 105 110 115 age atg ggg gta cag cat gat gtc cgg ctt aaa acg atg cgc tea ttg 499 Being Met Gly Val Gln His Asp Val Arg Leu Lys Thr Met Arg Ser Leu 120 125 130 cag aac etc gat ggg cca ggt cag gac tet att cgc here ggc ca gta 547 Gln Asn Leu Asp Gly Pro Gly Gln Asp Ser He Arg Thr Gly Gln Val 135 140 145 gtc agt cgg tcc att tcg gat ate aac atg gtg ca a age ctt gtg gcg 595 Val Ser Arg Ser He Be Asp He Asn Met Val Gln Ser Leu Val Wing 150 155 160 165 atg ttg ccg atg ttg ate gga aat gtg gtc aag ctt gtg etc act ttg 643 Met Leu Pro Met Leu He Gly Asn Val Val Lys Leu Val Leu Thr Leu 170 175 180 gtg ate atg ctg gct att tcc ccg ccg ctg acc ate ate gct gca gtg 691 Val He Met Leu Wing He Pro Pro Leu Thr He He Wing Wing Val 185 190 195 ttg gtg ect ttg ctg ttg tgg gcc gtg gcc tat tcg cga aaa gcg ctt 739 Leu Val Pro Leu Leu Leu Trp Wing Val Wing Tyr Being Arg Lys Wing Leu 200 205 210 ttt gcg tcc acg tgg tcg gcc cag ca g a g gg gc gt gc gt gcg acc 787 Phe Wing Being Thr Trp Being Wing Gln Gln Lys Wing Wing Asp Leu Thr Thr & -a - * - ü, A - ^ 215 220 225 cat gtg gaa gaa act gtc acg ggt ate cgc gtg gtc aag gca ttt gcg 835 His Val Glu Glu Thr Val Thr Gly He Arg Val Val Lys Ala Phe Ala 230 235 240 245 cag gaa gac cgc gag acc gac aaa ttg gat etc acc gca cgt gag tta 883 Gln Glu Asp Arg Glu Thr Asp Lys Leu Asp Leu Thr Wing Arg Glu Leu 250 255 260 ttt gcc cag cgc atg cgc act gca cgt ctg acg gca aag ttc ate ccc 931 Phe Wing Gln Arg Met Arg Thr Wing Arg Leu Thr Wing Lys Phe He Pro 265 270 275 atg gtt gag cag ctt ccg cag ctt gct ttg gtg gtc aac att gtt ggc 979 Met Val Glu Gln Leu Pro Gln Leu Ala Leu Val Val Asn He Val Gly 280 285 290 ggt ggc tat ttg gcc atg act ggt falls ate acg gtg ggc acg ttt gtg 1027 Gly Gly Tyr Leu Ala Met Thr Gly His He Thr Val Gly Thr Phe Val 295 300 305 gcg ttt tet tcc tat etc act age ttg tcg gcg gtg gct agg tcc ctg 1075 Wing Phe Ser Ser Tyr Leu Thr Ser Leu Ser Wing Val Wing Arg Ser Leu 310 315 320 325 tcg ggc atg etc atg cgc gtg cag ttg gcg ctg tet tet gtg gag cgc 1123 Ser Gly Met Leu Met Arg Val Gln Leu Ala Leu Ser Ser Val Glu Arg 330 335 340 ate ttt gaa gtc att gat ctt cag ect gaa cgc acc gat ect gca falls 1171 He Phe Glu Val He Asp Leu Gln Pro Glu Arg Thr Asp Pro Wing His 345 350 355 ccc ctg tea ctt ccc gac act ccc ctg ggt ctg tcg ttc aac aac gta 1219 Pro Leu Ser Leu Pro Asp Thr Pro Leu Gly Leu Ser Phe Asn Asn Val 360 365 370 gat ttc cgt ggg att aac ggt ttt gag ctg ggt gtt cag gcc ggt 1267 Asp Phe Arg Gly He Leu Asn Gly Phe Glu Leu Gly Val Gln Wing Gly 375 380 385 gaa acc gtt gtg ttg gtg ggc ect cca ggt tea ggc aag acc atg gct 1315 Glu Thr Val Val Leu Val Gly Pro Pro Gly Ser Gly Lys Thr Met Wing 390 '395 400 405 gtg cag ctt gct aga gt aac ttt tat caca cca gac age ggc cae ate gcc 1363 Val Gln Leu Wing Gly Asn Phe Tyr Gln Pro Asp Ser Gly His He Wing 410 415 420 ttt gat age aac ggc cat cgc act cgc ttc gac gac etc acc fall age 1411 Phe Asp Ser Asn Gly His Arg Thr Arg Phe Asp Asp Leu Thr His Ser 425 430 435 gat ate cgc agg aat etc gcg gtt ttt gat gag ccg ttc ttg tac 1459 Asp He Arg Arn Asn Leu He Wing Val Phe Asp Glu Pro Phe Leu Tyr 440 445 450 tcc tcc tcc ata ccg cga gaga cat etc gat ggg ttt gga tgt cag 1504 Be Ser Be He Pro Arg Glu His Leu Asp Gly Phe Gly Cys Gln 455 460 465 tgatgagcag ategaacaeg cag 1527 < 210 > 324 < 211 > 468 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 324 Met Lys Thr Glu Gln Ser Gln Lys Wing Gln Leu Wing Pro Lys Lys Wing 1 5 10 15 Pro Glu Lys Pro Gln Arg He Arg Gln Leu He Ser Val Wing Trp Gln 20 25 30 Arg Pro Trp Leu Thr Ser Phe Thr Val He Be Ala Leu Ala Ala Thr 35 40 45 Leu Phe Glu Leu Thr Leu Pro Leu Leu Thr Gly Gly Wing He Asp He 50 55 60 Wing Leu Gly Asn Thr Gly Asp Thr Leu Thr Thr Asp Leu Leu Asp Arg 65 70 75 80 Phe Thr Pro Ser Gly Leu Ser Val Leu Thr Ser Val He Ala Leu He 85 90 95 • Val Leu Leu Ala Leu Leu Arg Tyr Ala Ser Gln Phe Gly Arg Arg Tyr 100 105 110 Thr Wing Gly Lys Leu Ser Met Gly Val Gln His Asp Val Arg Leu Lys 115 120 125 Thr Met Arg Ser Leu Gln Asn Leu Asp Gly Pro Gly Gln Asp Ser He 130 135 140 Arg Thr Gly Gln Val Val Ser Arg Ser He Ser Asp He Asn Met Val 145 150 155 160 Gln Ser Leu Val Ala Met Leu Pro Met Leu He Gly Asn Val Val Lys 165 170 175 Leu Val Leu Thr Leu Val He Met Leu Ala He Ser Pro Pro Leu Thr 10 180 185 190 He He Ala Ala Val Leu Val Pro Leu Leu Leu Trp Ala Val Ala Tyr 195 200 205 Be Arg Lys Ala Leu Phe Wing Be Thr Trp Be Wing Gln Gln Lys Wing • 210 215 220 Wing Asp Leu Thr Thr His Val Glu Glu Thr Val Thr Gly He Arg Val 225 230 235 240 Val Lys Wing Phe Wing Gln Glu Asp Arg Glu Thr Asp Lys Leu Asp Leu 245 250 255 Thr Wing Arg Glu Leu Phe Wing Gln Arg Met Arg Thr Wing Arg Leu Thr 260 265 270 Wing Lys Phe He Pro Met Val Glu Gln Leu Pro Gln Leu Wing Leu Val 15 275 280 285 Val Asn He Val Gly Gly Gly Tyr Leu Wing Met Thr Gly His He Thr 290 295 300 Val Gly Thr Phe Val Wing Phe Ser Ser Tyr Leu Thr Ser Leu Ser Wing 305 310 315 320 Val Wing Arg Ser Leu Ser Gly Met Leu Met Arg Val Gln Leu Ala Leu 325 330 335 Ser Ser Val Glu Arg He Phe Glu Val He Asp Leu Gln Pro Glu Arg 340 345 350 • Thr Asp Pro Ala Pro His Leu Ser Leu Pro Asp Thr Pro Leu Gly Leu 355 360 365 Ser Phe Asn Asn Val Asp Phe Arg Gly He Leu Asn Gly Phe Glu Leu 20 370 375 380 Gly Val Gln Wing Gly Glu Thr Val Val Leu Val Gly Pro Pro Gly Ser 385 390 395 400 Gly Lys Thr Met Wing Val Gln Leu Wing Gly Asn Phe Tyr Gln Pro Asp 405 410 415 Ser Gly His He Wing Phe Asp Ser Asn Gly His Arg Thr Arg Phe Asp 420 425 430 Asp Leu Thr His Ser Asp He Arg Arg Asn Leu He Allah Val Phe Asp 435 440 445 Glu Pro Phe Leu Tyr Being Being Pro He Arg Glu His Leu Asp Gly 450 455 460 Phe Gly Cys Gln 25 465 t » i M < 210 > 325 < 211 > 905 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (882) < 223 > RXA02225 < 400 > 325 caá act gag gag cgc ttt ggc gca gcg gct gat gaa gcc ttg gca ate 48 Gln Thr Glu Glu Arg Phe Gly Wing Wing Wing Asp Glu Wing Leu Wing He 1 5 10 15 atg ttg aag gaa gct cgt ctg cag tcg ttg ctg act ttt gtg cgc caa 96 Met Leu Lys Glu Ala Arg Leu Gln Ser Leu Leu Thr Phe Val Arg Gln 20 25 30 ctt gtc cca gcg gtg ttt tet gtg ggt ctt ttg gct tat gcg tea ctg 144 Leu Val Pro Ala Val Phe Ser Val Gly Leu Leu Ala Tyr Ala Ser Leu 35 40 45 ttg gct ttt gac ggt gac ata act ggt ggt gag atg ate tcg gtg acg 192 Leu Ala Phe Asp Gly Asp He Thr Gly Gly Glu Met He Ser Val Thr 50 55 60 ttg ctg gtg cca ect tcg ttg act gtg ttg ggt gtg tcg ctt ggc atg 240 Leu Leu Val Pro Pro Ser Leu Thr Val Leu Gly Val Ser Leu Gly Met 65 70 75 80 atg here gag att tgg gct agg gga cag gct tcg here aaa agg gtc caá 288 Met Thr Glu He Trp Wing Arg Gly Gln Wing Being Thr Lys Arg Val Gln 85 90 95 aac tta gtc act gaa ctg gat aag gcg gcc gct gag cca cga ect cag 336 Asn Leu Val Thr Glu Leu Asp Lys Wing Wing Wing Glu Pro Arg Pro Gln 100 105 110 ect gcc acc ttt gaa ttt gaa gag ggg ate acg gtg tgg gat ect tcg 384 Pro Wing Thr Phe Glu Phe Glu Glu Gly He Thr Val Trp Asp Pro Ser 115 120 125 here ect gag gca cgc gat gtg att gat cgg gag ttg gag gcg ctt cag 432 Thr Pro Glu Wing Arg Asp Val He Asp Arg Glu Leu Glu Wing Leu Gln 130 135 140 gtt cgc gaa gat gtc att gtg gct ect cae cgc gtc age gtg ttt gaa 480 Val Arg Glu Asp Val He Val Val Pro Pro His Arg Val Ser Val Phe Glu 145 150 155 160 ggt gtg ctg aag gat aat ttg aat ccg atg ggc act ate gca ccg gag 528 Gly Val Leu Lys Asp Asn Leu Asn Pro Met Gly Thr He Wing Pro Glu 165 170 175 atg ctg cgc gct gct ctt cat gct gca agt tgt gag gac ate ttg age 576 Met Leu Arg Ala Ala Leu His Ala Ala Ser Cys Glu Asp He Leu Ser 180 185 190 cga ttg ggt gct gat ctg aac atg ccg ggg gag ttt gag ctt cca gat 624 Arg Leu Gly Wing Asp Leu Asn Met Pro Gly Glu Phe Glu Leu Pro Asp 195 200 205 acc ttg ate ggc gag gcc gga ttg aat etc tcc ggt ggc caa cgc cag 672 Thr Leu He Gly Glu Wing Gly Leu Asn Leu Ser Gly Gly Gln Arg Gln 210 215 220 agg att gct ttg gca cga ttc ttg gct gtt gat ect gag gtg etc att 720 Arg He Ala Leu Ala Arg Phe Leu Ala Val Asp Pro Glu Val Leu He 225 230 235 240 ttg gat gaa ccg acc acg ggg ttg gat gcg gtg acc ctg gat gaa gtg 768 Leu Asp Glu Pro Thr Thr Gly Leu Asp Wing Val Thr Leu Asp Glu Val 245 250 255 gca cat cgc gtc gaa aag ctt cgt cga ggc cgg aaa acc gtc gtc att 816 Ala His Arg Val Glu Lys Leu Arg Arg Gly Arg Lys Thr Val Val He 260 265 270 acg tcg aac ccg acg tgg cae ggc gtc gca aag cag atg cag tet gat 864 Thr Ser Asn Pro Thr Trp His Gly Val Ala Lys Gln Met Gln Ser Asp 275 280 285 ttt tcg gaa ggg gtg aag tagatggcgc agcatgagcg cgt 905 Phe Ser Glu Gly Val Lys 290 < 210 > 326 < 211 > 294 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 326 Gln Thr Glu Glu Arg Phe Gly Wing Wing Wing Asp Glu Wing Leu Wing He 1 5 10 15 Met Leu Lys Glu Wing Arg Leu Gln Ser Leu Leu Thr Phe Val Arg Gln 20 25 30 Leu Val Pro Wing Val Phe Ser Val Gly Leu Leu Ala Tyr Ala Ser Leu 35 40 45 Leu Ala Phe Asp Gly Asp He Thr Gly Glu Met He Ser Val Thr 50 55 60 Leu Leu Val Pro Pro Ser Leu Thr Val Leu Gly Val Ser Leu Gly Met 65 70 75 80 Met Thr Glu He Trp Wing Arg Gly Gln Wing Being Thr Lys Arg Val Gln 85 90 95 Asn Leu Val Thr Glu Leu Asp Lys Wing Wing Wing Glu Pro Arg Pro Gln 100 105 110 Pro Wing Thr Phe Glu Phe Glu Glu Gly He Thr Val Trp Asp Pro Ser 115 120 125 Thr Pro Glu Wing Arg Asp Val He Asp Arg Glu Leu Glu Wing Leu Gln 130 135 140 Val Arg Glu Asp Val He Val Pro Wing His Arg Val Ser Val Phe Glu 145 150 155 160 Gly Val Leu Lys Asp Asn Leu Asn Pro Met Gly Thr He Wing Pro Glu 165 170 175 Met Leu Arg Ala Wing Leu His Wing Wing Cys Glu Asp He Leu Ser 180 185 190 Arg Leu Gly Wing Asp Leu Asn Met Pro Gly Glu Phe Glu Leu Pro Asp 195 200 205 T hr Leu He Gly Glu Wing Gly Leu Asn Leu Ser Gly Gly Gln Arg Gln 210 215 220 Arg He Wing Leu Wing Arg Phe Leu Wing Val Asp Pro Glu Val Leu He 225 230 235 240 Leu Asp Glu Pro Thr Thr Gly Leu Asp Wing Val Thr Leu Asp Glu Val 245 250 255 Wing His Arg Val Glu Lys Leu Arg Arg Gly Arg Lys Thr Val Val He 260 265 270 Thr Ser Asn Pro Thr Trp His Gly Val Ala Lys Gln Met Gln Ser Asp 275 280 285 Phe Ser Glu Gly Val Lys 290 i f «IMBUÍ < 210 > 327 < 211 > 1050 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1027 < 223 > RXA02253 < 400 > 327 tga < ggacatt -tcccaagtga aaggcttcgg cccgaa, actt gcggaggetg 'tetatgaagg 60 tcttcacigcg • tcaaaataag t; agat < oget; a ggatgt, aacc atg att cacc tcc act 115 Met He Gln Ser Thr 1 5 ggg gtc acg falls act gat aag tet gca caa gaa aat ect gtg aag tac 163 Gly Val Thr His Thr Asp Lys Ser Wing Gln Glu Asn Pro Val Lys Tyr 10 15 20 agg gac aat ttc here ect gtc ate ate ggt atg tea ggc gca ggt 211 Arg Asp Asn Phe Thr Pro Val He He Thr Gly Met Ser Gly Wing Gly 25 30 35 ctg age here gca gcc cga gtc etc gaa gac ttg ggt tgg tat gtg gcg 259 Leu Ser Thr Wing Wing Arg Val Leu Glu Asp Leu Gly Trp Tyr Val Wing 40 45 50 falls aat att cca cca cag ate ate ctg gaa tta att gat atg tgc gct 307 His Asn He Pro Pro Gln He He Leu Glu Leu He Asp Met Cys Wing 55 60 65 cgg gaa gat tet ccc gtc gac aaa gtt gca gtc gtg tgc gat gtg cgc 355 Arg Glu Asp Ser Pro Val Asp Lys Val Wing Val Val Cys Asp Val Arg 70 75 80 85 tcc cgt gaa ttc cgc gga age etc acc ca gtt gtt tea gag ctg cgt 403 Be Arg Glu Phe Arg Gly Be Leu Thr Gln Val Val Ser Glu Leu Arg 90 95 100 gat aag cag etc gat ccc acg gtg tta ttt ctg gaa gca cgc gat gag 451 Asp Lys Gln Leu Asp Pro Thr Val Leu Phe Leu Glu Wing Arg Asp Glu 105 110 115 gtg ctg ate aag cga ttc gat aat gtg cgc cgc acc cat ect ttg cag 499 Val Leu He Lys Arg Phe Asp Asn Val Arg Arg Thr His Pro Leu Gln 120 125 130 ggc age cac acc ctt cag gtg ggt att gaa cgt gaa cga acc gtg ctg 547 Gly Ser Gln Thr Leu Gln Val Gly He Glu Arg Glu Arg Thr Val Leu 135 140 145 tet ect gtg aag gaa gac gct tea gtg gtc ate gat acc tcg gat ctg 595 Ser Pro Val Lys Glu Asp Ala Ser Val Val He Asp Thr Ser Asp Leu 150 155 160 165 tcc gtg cat gat ttg cgc cgc gcc ate gaa tcc tcg ttt agg a ate 643 Ser Val His Asp Leu Arg Arg Wing He Glu Be Ser Phe Arg Thr He 170 175 180 gcc acg cgc acc cag falls gtc acc att gaa tea ttc ggt ttc aaa falls 691 Ala Thr Arg Thr Gln His Val Thr He Glu Ser Phe Gly Phe Lys His 185 190 195 ggc tea cca cgc gac gcc gac ttt gtt gtg gac gtg cgt ttc ttg ccg 739 Gly Ser Pro Arg Asp Wing Asp Phe Val Val Asp Val Arg Phe Leu Pro 200 205 210 aac cca ttc tgg gtt cca gag ctg cgc cca ttt agg gga gtg gac aag 787 Asn Pro Phe Trp Val Pro Glu Leu Arg Pro Phe Arg Gly Val Asp Lys . , * L. * rí.r? 215 220 225 cca gta tet gac tat gtg etc tcc caa aaa ggc gca gaa gaa ttt ttg 835 Pro Val As Asp Tyr Val Leu Ser Gln Lys Gly Ala Glu Glu Phe Leu 230 235 240 245 aac aac ttt gtg gac atg etc aaa gac atg ctt ccg gga tac cgc drops 883 Asn Asn Phe Val Asp Met Leu Lys Asp Met Leu Pro Gly Tyr Arg His 250 255 260 gaa gga aaa aac ttc ate here ggt gtc ggc tgc acc ggt gga falls 931 Glu Gly Lys Asn Phe He Thr He Gly Val Gly Cys Thr Gly Gly His 265 270 275 falls aga tea gtt gcg gtg tet gaa gaa cta gcc aaa aga ate gca gat 979 His Arg Ser Val Wing Val Ser Glu Glu Leu Wing Lys Arg He Wing Asp 280 285 290 cag acc acg etc gac gtg tet gta gta falls cgc gat att aac cgc falls 1027 Gln Thr Thr Leu Asp Val Ser Val Val His Arg Asp He Asn Arg His 295 300 305 taggaaaggg gccaactaat tga 1050 < 210 > 328 < 211 > 309 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 328 Met He Gln Ser Thr Gly Val Thr His Thr Asp Lys Ser Wing Gln Glu 1 5 10 15 Asn Pro Val Lys Tyr Arg Asp Asn Phe Thr Pro Val He He Thr Gly 20 25 30 Met Ser Gly Wing Gly Leu Ser Thr Wing Wing Arg Val Leu Glu Asp Leu 35 40 45 Gly Trp Tyr Val Wing His Asn He Pro Pro Gln He He Leu Glu Leu 50 55 60 He Asp Met Cys Wing Arg Glu Asp Ser Pro Val Asp Lys Val Wing Val 65 70 75 80 Val Cys Asp Val Arg Ser Arg Glu Phe Arg Gly Ser Leu Thr Gln Val 85 90 95 Val Ser Glu Leu Arg Asp Lys Gln Leu Asp Pro Thr Val Leu Phe Leu 100 105 110 Glu Ala-Arg Asp Glu Val Leu He Lys Arg Phe Asp Asn Val Arg Arg 115 120 125 Thr His Pro Leu Gln Gly Ser Gln Thr Leu Gln Val Gly He Glu Arg 130 135 140 Glu Arg Thr Val Leu Ser Pro Val Lys Glu Asp Ala Ser Val Val He 145 150 155 160 Asp Thr Ser Asp Leu Ser Val His Asp Leu Arg Arg Wing He Glu Ser 165 170 175 Be Phe Arg Thr He Wing Thr Arg Thr Gln His Val Thr He Glu Ser 180 185 190 Phe Gly Phe Lys His Gly Ser Pro Arg Asp Ala Asp Phe Val Val Asp 195 200 205 Val Arg Phe Leu Pro Asn Pro Phe Trp Val Pro Glu Leu Arg Pro Phe 210 215 220 Arg Gly Val Asp Lys Pro Val Ser Asp Tyr Val Leu Ser Gln Lys Gly 225 230 235 240 Wing Glu Glu Phe Leu Asn Asn Phe Val Asp Met Leu Lys Asp Met Leu 245 250 255 Pro Gly Tyr Arg His Glu Gly Lys Asn Phe He Thr He Gly Val Gly 260 265 270 Cys Thr Gly Gly His His Arg Ser Val Wing Val Ser Glu Glu Leu Wing 275 280 285 Lys Arg He Wing Asp Gln Thr Thu Leu Asp Val Ser Val Val His Arg 290 295 300 Asp He Asn Arg His 305 < 210 > 329 • < 211 > 558 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (535) < 223 > RXN01881 < 400 > 329 accggccctg cggcctcaac cgccgaccag cgcggcgcac acattttgac tgtttcataa 60 10 taaagacaaa cttaagtatc ggagtcgaag aaaaaccaca atg gcc aat ctg att 115 Met Wing Asn Leu He 1 5 aat etc gag aac gtc tcc aaa acc tgg gga tta aaa acg ctt etc gac 163 • Asn Leu Glu Asn Val Ser Lys Thr Trp Gly Leu Lys Thr Leu Leu Asp 10 15 20 ggt gtc tcc tta ggt gtt ca acc ggc gac cgc att ggc gtc gtc ggc 211 Gly Val Ser Leu Gly Val Gln Thr Gly Asp Arg He Gly Val Val Gly 25 30 35 etc aat ggt ggc gga aaa acc acc ctg ctg gaa gta ctt act ggc ate 259 Leu Asn Gly Gly Gly Lys Thr Thr Leu Leu Glu Val Leu Thr Gly He 40 45 50 15 gaa aag ccg gat cag ggc cgt gtg tet falls aac tet gac ctg cgc atg 307 Glu Lys Pro Asp Gln Gly Arg Val Ser His Asn Ser Asp Leu Arg Met 55 60 65 gct gtg gtg acg cag cgt gct gaa etc aat gat gac gac acc gtc gct 355 Wing Val Val Thr Gln Arg Ala Glu Leu As Asp Asp Asp Thr Val Wing 70 75 80 85 gac gtg gtg ctt gga ect ttg ggt ttg gaa gtt ttc gaa tgg gca tea 403 Asp Val Val Leu Gly Pro Leu Gly Leu Glu Val Phe Glu Trp Wing Ser 90 95 100 aac gcc acg gtg cgc gac gtc etc ggt ggc ttg ggc att gtc gat ctt 451 Asn Ala Thr Val Arg Asp Val Leu Gly Gly Leu Gly He Val Asp Leu 105 110 115 20 ggc ctt gac acc aag gtg ggc aaa ect ttt ccg gtg ggc gaa gcg ccg 499 Gly Leu Asp Thr Lys Val Gly Lys Pro Phe Pro Val Gly Glu Pro Wing 120 125 130 acg falls ca ect ggc cgc cgc gct ggt tcg cga ect tgacctgatc 545 Thr His Gln Pro Gly Arg Arg Wing Gly Ser Arg Pro 135 140 145 gtgctcgacg age 558 <; 210 > 330 < 211 > 145 < 212 > PRT < 213 > Corynebacterium glutamicum 25 - »*.«.! Í.? < 400 > 330 Met Ala Asn Leu He Asn Leu Glu Asn Val Ser Lys Thr Trp Gly Leu 1 5 10 15 Lys Thr Leu Leu Asp Gly Val Ser Leu Gly Val Gln Thr Gly Asp Arg 20 25 30 He Gly Val Val Gly Leu Asn Gly Gly Gly Lys Thr Thu Leu Leu Glu 35 40 45 Val Leu Thr Gly He Glu Lys Pro Asp Gln Gly Arg Val Ser His Asn • 50 55 60 Ser Asp Leu Arg Met Wing Val Val Thr Gln Arg Ala Glu Leu Asn Asp 65 70 75 80 Asp Asp Thr Val Wing Asp Val Val Leu Gly Pro Leu Gly Leu Glu Val 85 90 95 Phe Glu Trp Wing Ser Asn Wing Thr Val Arg Asp Val Leu Gly Gly Leu 100 105 110 Gly He Val Asp Leu Gly Leu Asp Thr Lys Val Gly Lys Pro Phe Pro 115 120 125 Val Gly Glu Ala Pro Thr His Gln Pro Gly Arg Arg Ala Gly Ser Arg 130 135 140 Pro 10 145 < 210 > 331 < 211 > 564 • < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (541) < 223 > FRXA01881 15 < 400 > 331 accggcct; tg icggcctcaac cgccgaccag cgcggcgcac acattttgac tgtttcataa 60 taaagacaaa < cttaagtatc ggagtcgaag aaaaaccaca atg gcc aat ctg att 115 Met Wing Asn Leu He 1 5 aat etc gag aac gtc tcc aaa acc tgg gga tta aaa acg ctt etc gac 163 Asn Leu Glu Asn Val Ser Lys Thr Trp Gly Leu Lys Thr Leu Leu Asp 10 15 20 ggt gtc tcc tta ggt gtt ca gcc gc gc gc gc gc gcc Gly Val Ser Leu Gly Val Gln Thr Gly Asp Arg He Gly Val Val Gly 25 30 35 etc aat ggt ggc gga aaa acc acc ctg ctg gaa gta ctt act ggc ate 259 20 Leu Asn Gly Gly Gly Lys Thr Thr Leu Leu Glu Val Leu Thr Gly He 40 45 50 gaa aag ccg gat cag ggc cgt gtg tet falls aac tet gac ctg cgc atg 307 Glu Lys Pro Asp Gln Gly Arg Val Ser His Asn Ser Asp Leu Arg Met 55 60 65 gct gtg acg cag cgt gct gaa etc aat gat gac gac acc gtc gct 355 Wing Val Val Thr Gln Arg Wing Glu Leu Asn Asp Asp Asp Thr Val Wing 70 75 80 85 gac gtg gtg ctt gga ect ttg ggt ttg gaa gtt ttc gaa tgg gca tea 403 Asp Val Val Leu Gly Pro Leu Gly Leu Glu Val Phe Glu Trp Wing Ser 90 95 100 aac gcc acg gtg cgc gac gtc etc ggt ggc ttg ggc att gtc gat ctt 451 25 Asn Wing Thr Val Arg Asp Val Leu Gly Gly Leu Gly He Val Asp Leu 105 110 115 ggc ctt gac acc aag gtg ggg ca gt acc gtt ggg tg ggg cga age gcc 499 Gly Leu Asp Thr Lys Val Gly Gln Thr Phe Ser Gly Gly Arg Ser Wing 120 125 130 gac gca cca acc tgg ccg ccg cgc tgg tc gcg acc ttg acc 541 Asp Wing Pro Thr Trp Pro Pro Arg Trp Phe Wing Thr Leu Thr 135 140 145 tgatcgtgct cgacgagccc acc 564 • < 210 > 332 < 211 > 147 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 332 Met Wing Asn Leu He Asn Leu Glu Asn Val Ser Lys Thr Trp Gly Leu 1 5 10 15 Lys Thr Leu Leu Asp Gly Val Ser Leu Gly Val Gln Thr Gly Asp Arg 20 25 30 He Gly Val Val Gly Leu Asn Gly Gly Gly Lys Thr Thu Leu Leu Glu 10 35 40 45 Val Leu Thr Gly He Glu Lys Pro Asp Gln Gly Arg Val Ser His Asn 50 55 60 Ser Asp Leu Arg Met Wing Val Val Thr Gln Arg Ala Glu Leu Asn Asp • 65 70 75 80 Asp Asp Thr Val Wing Asp Val Val Leu Gly Pro Leu Gly Leu Glu Val 85 90 95 Phe Glu Trp Wing Ser Asn Wing Thr Val Arg Asp Val Leu Gly Gly Leu 100 105 110 Gly He Val Asp Leu Gly Leu Asp Thr Lys Val Gly Gln Thr Phe Ser 115 120 125 Gly Gly Arg Ser Wing Asp Wing Pro Thr Trp Pro Pro Arg Trp Phe Wing 15 130 135 140 Thr Leu Thr 145 < 210 > 333 < 211 > 813 < 212 > DNA < 213 > Corynebacterium glutamicum • < 220 > < 221 > CDS < 222 > (101) .. (790) 20 < 223 > RXA00526 < 400 > 333 ggtggagcag gcggcggctc cttttagtcc tgcggcccct tttgaccctg cagcccctgc 60 cgtttctgcc aagcaaaccg tgggccaggt gatttagcct atg age etc ate gaa 115 Met Ser Leu He Glu 1 5 atg cga aat att gtc aag acc tac aac att gga tet gaa ggt gaa etc 163 Met Arg Asn He Val Lys Thr Tyr Asn He Gly Ser Glu Gly Glu Leu 10 15 20 acc gtg ttg falls ggt gtg gat ttc cat gtg gac cgt ggc gaa ttc gtg 211 Thr Val Leu His Gly Val Asp Phe His Val Asp Arg Gly Glu Phe Val 25 25 30 35 tcg gtt gtg ggt acg tcc ggc tea ggt aaa tea acg atg atg aac ate 259 Ser Val Val Gly Thr Ser Gly Ser Gly Lys Ser Thr Met Met Asn He 40 45 50 att ggg ttg ttg gat aag cca act gat ggc acg tac acc ttg gat ggc 307 He Gly Leu Leu Asp Lys Pro Thr Asp Gly Thr Tyr Thr Leu Asp Gly 55 60 65 gtg gat gtg ttg gat ate age gat gat gct ttg gcg age falls cgc gct 355 Val Asp Val Leu Asp As As Asp Ala Leu Ala Ser His Arg Ala 70 75 80 85 • aaa tcg att ggt ttt gtg ttt cag aac ttc aat ctg att ggc cgg ate 403 Lys Ser He Gly Phe Val Phe Gln Asn Phe Asn Leu He Gly Arg He 90 95 100 gat gcg ttg aag aat gtg gaa atg ccc atg tat gcg ggc att ccg 451 Asp Ala Leu Lys Asn Val Glu Met Pro Met Met Tyr Ala Gly He Pro 105 110 115 gct aag cag cgg aga agt cgt gcg gtt gaa tta ttg gaa atg gtc ggg 499 Wing Lys Gln Arg Arg Ser Arg Wing Val Glu Leu Leu Glu Met Val Gly 120 125 130 atg ggt gag cgt etc aac cat gag ccc aat gag ctt tcg ggt ggt cag 547 Met Gly Glu Arg Leu Asn His Glu Pro Asn Glu Leu Ser Gly Gly Gln 135 140 145 10 aag cag cgc gtg gcc att gct cgc gcg ttg gcg aac gat ect gag ate 595 Lys Gln Arg Va l Ala He Ala Arg Ala Leu Ala Asn Asp Pro Glu He 150 155 160 165 • att ctt gct gat gaa cca act ggt gcg ttg gat tet gca acg ggc cgg 643 He Leu Wing Asp Glu Pro Thr Gly Wing Leu Asp Being Wing Thr Gly Arg 170 175 180 atg gtg atg gat att ttc falls cag etc aac aag gag cag ggc aaa acc 691 Met Val Met Asp He Phe His Gln Leu Asn Lys Glu Gln Gly Lys Thr 185 190 195 ate gtg ttt att act falls aac ect gag ctt gct gat gaa tet gat cgg 739 Hee Val Phe He Thr His Asn Pro Glu Leu Wing Asp Glu Be Asp Arg 200 205 210 15 gtg gtc acc atg gtt gac ggg cgc ate att ggg tet gag gtg aaa drops 787 Val Val Thr Met Val Asp Gly Arg He He Gly Ser Glu Val Lys His 215 220 225 tea tgagccttgc agaatcaatt ctt 813 Ser 230 <; 210 > 334 < 211 > 230 < 212 > PRT < 213 > Corynebacterium glutamicum 20 < 400 > 334 Met Ser Leu He Glu Met Arg Asn He Val Lys Thr Tyr Asn He Gly 1 5 10 15 Ser Glu Glu Glu Leu Thr Val Leu His Gly Val Asp Phe His Val Asp 20 25 30 Arg Gly Glu Phe Val Ser Val Val Gly Thr Ser Gly Ser Gly Lys Ser 35 40 45 Thr Met Met Asn He He Gly Leu Leu Asp Lys Pro Thr Asp Gly Thr 50 55 60 Tyr Thu Leu Asp Gly Val Asp Val Leu Asp He Ser Asp Asp Ala Leu 65 70 75 80 25 Wing Ser His Arg Ala Lys Ser He Gly Phe Val Phe Gln Asn Phe Asn . . . M ^ r ^ a 90 95 Leu He Gly Arg He Asp Ala Leu Lys Asn Val Glu Met Pro Met Met Met 105 105 110 Tyr Ala Gly He Pro Ala Lys Gln Arg Arg Ser Arg Ala Val Glu Leu 115 120 125 Leu Glu Met Val Gly Met Gly Glu Arg Leu Asn His Glu Pro Asn Glu 130 135 140 Leu Ser Gly Gly Gln Lys Gln Arg Val Wing He Wing Arg Ala Leu Wing 145 150 155 160 Asn Asp Pro Glu He He Leu Wing Asp Glu Pro Thr Gly Wing Leu Asp 165 170 175 Being Wing Thr Gly Arg Met Val Met Asp He Phe His Gln Leu Asn Lys 180 185 190 Glu Gln Gly Lys Thr He Val Phe He Thr His Asn Pro Glu Leu Ala 195 200 205 Asp Glu Be Asp Arg Val Val Thr Met Val Asp Gly Arg He He Gly 210 215 220 Ser Glu Val Lys His Ser 225 230 < 210 > 335 < 211 > 1008 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (985) < 223 > RXN00733 < 400 > 335 acggcgaggt 1tgtciggtatt ggaactgcaca cg; aatttgct gaac; acgtgc < ggtacctacc 60 gtg; aaattgt 'tgaaiteccaa gagadcgcgt 2 aggcgcaatc atg agt aat act gca 115 Met Ser Asn Thr Wing 1 5 ggc ccc cgc ggg cgt tcc cat cag gca gac gcc gcg ccg aat caa aag 163 Gly Pro Arg Gly Arg Ser His Gln Wing Asp Wing Wing Pro Asn Gln Lys 10 15 20 gca cag aat ttc gga cca tet gcc aaa agg ctt ttc gga att cta ggc 211 Ala Gln Asn Phe Gly Pro Be Ala Lys Arg Leu Phe Gly He Leu Gly 25 30 35 cat gac cgt aac acc tta att ttt gtt ate tcc cta gcc gtc ctg age 259 His Asp Arg Asn Thr Leu He Phe Val He Phe Leu Wing Val Leu Ser 40 45 50 gtt gga ctt acc gtc ttg ggc cca tgg ttg ctg ggt aaa gcc acc aac 307 Val Gly Leu Thr Val Leu Gly Pro Trp Leu Leu Gly Lys Wing Thr Asn 55 60 65 gtg gtg ttt gaa gga ttc cta tet aag cgc atg ccg gct ggt gcg tea 355 Val Val Phe Glu Gly Phe Leu Ser Lys Arg Met Pro Wing Gly Ala Ser 70 75 80 85 aag gaa gat ate ate gcg cag ttg cag gct gca ggt aaa cat aat cag 403 Lys Glu Asp He He Wing Gln Leu Gln Wing Wing Gly Lys His Asn Gln 90 95 100 gct tcc atg atg gaa atc aac ctt gtt cca ggc tea ggc att gat 451 Wing Met Met Met Glu Asp Met Asn Leu Val Pro Gly Ser Gly He Asp 105 110 115 ttt gaa aaa tta gcc atg ate gga etc gtg gtg ate ggt gct tat etc 499 Phe Glu Lys Leu Ala Met He Leu Gly Leu Val He Gly Ala Tyr Leu 120 125 130 ate ggt age ctg ttg tcg ttg ttc cag gcg cgg atg etc aac cgc ate 547 He Gly Being Leu Leu Being Leu Phe Gln Wing Arg Met Leu Asn Arg He 135 140 145 gtg caá agt gcc atg falls cgg cgc atg gag gtg gag gaa aaa ate 595 Val Gln Ser Ala Met His Arg Leu Arg Met Glu Val Glu Glu Lys He 150 155 160 165 falls cgc cta ccg ctg age tat ttc gat tcc ate aaa cgt ggt gat ctg 643 His Arg Leu Pro Leu Ser Tyr Phe Asp Ser He Lys Arg Gly Asp Leu 170 175 180 ctt age cgt gtg acc aac gat gtg gat aat ate ggt ca c tg ctg ca 691 Leu Ser Arg Val Thr Asn Asp Val Asp Asn He Gly Gln Ser Leu Gln 185 190 195 caà acc ttg tea cag gcg ate act tc cta ctg acc gtc ate ggt gtg 739 Gln Thr Leu Ser Gln Wing He Thr Ser Leu Leu Thr Val He Gly Val 200 205 210 ttg gtg atg att tt t ate ate tcc cca ctg etc gca etc gtg gcg ctg 787 Leu Val Met Met Phe He He Ser Pro Leu Leu Ala Leu Val Ala Leu 215 220 225 gta tcc att ccg gtc acc ate gtg gtc act gtg gtg gtt gcg age cgt 835 Val Ser He Pro Val Thr He Val Val Thr Val Val Val Ala Ser Arg 230 235 240 245 tcc cag aaa etc ttt gcg gaa cag tgg aag cag acc ggt att ttg aat 883 Being Gln Lys Leu Phe Wing Glu Gln Trp Lys Gln Thr Gly He Leu Asn 250 255 260 gcg cgc ctg gag gaa acc tac tet ggc falls gcc gtg gtt aag gtt ttc 931 Wing Arg Leu Glu Glu Thr Tyr Ser Gly His Wing Val Val Lys Val Phe 265 270 275 gga falls caa aag gat gtt caa gaa gca ttc gag gaa gaa aat ca gct 979 Gly His Gln Lys Asp Val Gln Glu Wing Phe Glu Glu Glu Asn Gln Wing 280 285 290 tgt gta taaggccagc tttggtgccc agt 100É Cys Val 295 < 210 > 336 < 211 > 295 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 336 Met Ser Asn Thr Wing Gly Pro Arg Gly Arg Ser His Gln Wing Asp Wing 1 5 10 15 Ala Pro Asn Gln Lys Ala Gln Asn Phe Gly Pro Be Ala Lys Arg Leu 20 25 30 Phe Gly He Leu Gly His Asp Arg Asn Thr Leu He Phe Val He Phe 35 40 45 Leu Ala Val Leu Ser Val Gly Leu Thr Val Leu Gly Pro Trp Leu Leu 50 55 60 Gly Lys Wing Thr Asn Val Val Phe Glu Gly Phe Leu Ser Lys Arg Met 65 70 75 80 Pro Ala Gly Ala Ser Lys Glu Asp He He Ala Gln Leu Gln Ala Ala 85 90 95 Gly Lys His Asn Gln Ala Met Met Met Glu Asp Met Asn Leu Val Pro 100 105 110 Gly Ser Gly He Asp Phe Glu Lys Leu Ala Met He Leu Gly Leu Val 115 120 125 He Gly Wing Tyr Leu He Gly Ser Leu Leu Ser Leu Phe Gln Wing Arg 130 135 140 Met Leu Asn Arg He Val Gln Ser Wing Met His Arg Leu Arg Met Glu 145 150 155 160 Val Glu Glu Lys He Hl? Arg Leu Pro Leu Ser Tyr Phe Asp Ser He 165 170 175 Lys Arg Gly Asp Leu Leu Ser Arg Val Thr Asn Asp Val Asp Asn He 180 185 190 Gly Gln Ser Leu Gln Gln Thr Leu Ser Gln Wing He Thr Ser Leu Leu 195 200 205 Thr Val He Gly Val Leu Val Met Met Phe He He Ser Pro Leu Leu 210 215 220 Wing Leu Val Wing Leu Val Ser He Pro Val Thr He Val Val Thr Val 225 230 235 240 Val Val Wing Ser Arg Ser Gln Lys Leu Phe Wing Glu Gln Trp Lys Gln 245 250 255 Thr Gly He Leu Asn Wing Arg Leu Glu Glu Thr Tyr Ser Gly His Wing 260 265 270 Val Val Lys Val Phe Gly His Gln Lys Asp Val Gln Glu Wing Phe Glu 275 280 285 Glu Glu Asn Gln Ala Cys Val 290 295 < 210 > 337 < 211 > 508 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (508) < 223 > FRXA00733 < 400 > 337 acggcgaggt tgteggtatt ggaaegeaca cgaatttgct gaacacgtgc ggtacctacc 60 gtgaaattgt tgaateccaa gagactgcgc aggcgcaatc atg agt aat act gca 115 Met Ser Asn Thr Wing 1 5 ggc ccc cgc ggg cgt tcc cat cag gca gac gcc gcg ccg aat caa aag 163 Gly Pro Arg Gly Arg Ser His Gln Wing Asp Wing Wing Pro Asn Gln Lys 10 15 20 gca cag aat ttc gga cca tet gcc aaa agg ctt ttc gga att cta ggc 211 Ala Gln Asn Phe Gly Pro Be Ala Lys Arg Leu Phe Gly He Leu Gly 25 30 35 cat gac cgt aac acc tta att ttt gtt ate tcc cta gcc gtc ctg age 259 His Asp Arg Asn Thr Leu He Phe Val He Phe Leu Wing Val Leu Ser 40 45 50 gtt gga ctt acc gtc ttg ggc cca tgg ttg ctg ggt aaa gcc acc aac 307 Val Gly Leu Thr Val Leu Gly Pro Trp Leu Leu Gly Lys Wing Thr Asn 55 60 65 gtg gtg ttt gaa gga ttc cta tet aag cgc atg ccg gct ggt gcg tea 355 Val Val Phe Glu Gly Phe Leu Ser Lys Arg Met Pro Ala Gly Wing Ser 70 75 80 85 aag gaa gat ate ate gcg cag ttg cag gct gca ggt aaa cat aat cag 403 Lys Glu Asp He He Wing Gln Leu Gln Wing Wing Gly Lys His Asn Gln 90 95 100 t gg tc atg atg gaa gac atg aac ctt gtt cca ggc tea ggc att gat 451 Wing Met Met Glu Asp Met Asn Leu Val Pro Gly Ser Gly He Asp 105 110 115 ttt gaa aaa tta gcc atg ate etc gga ctg gtg ate ggt gct tat etc 499 Phe Glu Lys Leu Wing Met He Leu Gly Leu Val He Gly Wing Tyr Leu 120 125 130 att cgt age 508 He Arg Ser 135 < 210 > 338 < 211 > 136 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 338 Met Ser Asn Thr Wing Gly Pro Arg Gly Arg Ser His Gln Wing Asp Wing 1 5 10 15 Wing Pro Asn Gln Lys Wing Gln Asn Phe Gly Pro Wing Wing Lys Arg Leu 20 25 30 10 Phe Gly He Leu Gly His Asp Arg Asn Thr Leu He Phe Val He Phe 35 40 45 Leu Wing Val Leu Ser Val Gly Leu Thr Val Leu Gly Pro Trp Leu Leu 50 55 60 • Gly Lys Wing Thr Asn Val Val Phe Glu Gly Phe Leu Ser Lys Arg Met 65 70 75 80 Pro Ala Gly Ala Ser Lys Glu Asp He He Ala Gln Leu Gln Ala Ala 85 90 95 Gly Lys His Asn Gln Ala Met Met Met Glu Asp Met Asn Leu Val Pro 100 105 110 Gly Ser Gly He Asp Phe Glu Lys Leu Ala Met He Leu Gly Leu Val 115 120 125 15 He Gly Wing Tyr Leu He Arg Ser 130 135 < 210 > 339 < 211 > .692 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > • < 221 > CDS < 222 > (1) .. (669) < 223 > RXA00735 20 < 400 > 339 ggt ccc acc ggt gcg ggc aag ac ttg gtg aat ctg ate atg cgt 48 Gly Pro Thr Gly Wing Gly Lys Thr Thr Leu Val Asn Leu He Met Arg 1 5 10 15 ttc tac gac ate aac age ggt tcc ate act ctt ggt gaa here gca caa 96 Phe Tyr Asp He Asn Ser Gly Ser He Thr Leu Gly Glu Thr Wing Gln 20 25 30 gac gcc gtg gat ate cgc acc atg gct aga gaa gat ctg cga tea cga 144 Asp Ala Val Asp He Arg Thr Met Ala Arg Glu Asp Leu Arg Ser Arg 35 40 45 acc ggc atg gtg ttg cag gat acg tgg ctg ttt gcc gga acc ate agg 192 25 Thr Gly Met Val Leu Gln Asp Thr Trp Leu Phe Wing Gly Thr He Arg Mm ^ 50 55 60 gat aac att ctt tac ggt aga ect gaa gca act gag gaa gaa atg ctt 240 Asp Asn He Leu Tyr Gly Arg Pro Glu Wing Thr Glu Glu Glu Met Leu 65 70 75 80 gct gcg tcc aag gcc gcc tac gtg gat cgt ttt gtc cgt tcc ctg cca 288 Ala Ala Ser Lys Ala Ala Tyr Val Asp Arg Phe Val Arg Ser Leu Pro 85 90 95 gaa ggc tac gac acc gta ctt gat gat gaa gcc atg aac cta tcg gtg 336 Glu Gly Tyr Asp Thr Val Leu Asp Asp Glu Wing Met Asn Leu Ser Val 100 105 110 ggt gaa cgc cag ctg ate acc ate gcg cgt gca ttc ttg gct aat ccc 384 Gly Glu Arg Gln Leu He Thr He Wing Arg Wing Phe Leu Wing Asn Pro 115 120 125 cga ctg ctg att ctg gat gaa gcc acc tcg gtg gat acg cgt acc 432 Arg Leu Leu He Leu Asp Glu Wing Thr Ser Ser Val Asp Thr Arg Thr 130 135 140 gaa ttg ttg att cag cgc gcc atg tcc aag ctg cgc caa gac cgc acc 480 Glu Leu Leu He Gln Arg Wing Met Ser Lys Leu Arg Gln Asp Arg Thr 145 150 155 160 gcc ttc gtc ate gcg falls cgg ttg tcc acg att cgt gat gcc aac ctg 528 Wing Phe Val He Wing His Arg Leu Being Thr He Arg Asp Wing Asn Leu 165 170 175 att ttg atg atg aaa gac ggc gag ate gtg gag cag ggc aat cae cgt 576 He Leu Met Met Lys Asp Gly Glu He Val Glu Gln Gly Asn His Arg 180 185 190 gag ttg atg gcc ctg gag ggc gca tat tgg gag ttg tat aac tcc ca 624 Glu Leu Met Wing Leu Glu Gly Wing Tyr Trp Glu Leu Tyr Asn Ser Gln 195 200 205 ttc aac gcc ccc gcg aaa gaa gaa tta cag gct gac gga gat falls 669 Phe Asn Ala Pro Ala Lys Glu Glu Leu Gln Wing Asp Gly Asp His 210 215 220 tgatgatttc ttcttaggct tt: c 692 < 210 > 340 < 211 > 223 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 340 Gly Pro Thr Gly Wing Gly Lys Thr Thr Leu Val Asn Leu He Met Arg 1 5 10 15 Phe Tyr Asp He Asn Ser Gly Ser He Thr Leu Gly Glu Thr Wing Gln 20 25 30 Asp Wing Val Asp He Arg Thr Met Wing Arg Glu Asp Leu Arg Ser Arg 35 40 45 Thr Gly Met Val Leu Gln Asp Thr Trp Leu Phe Wing Gly Thr He Arg 50 55 60 Asp Asn He Leu Tyr Gly Arg Pro Glu Wing Thr Glu Glu Glu Met Leu 65 70 75 80 Ala Ala Ser Lys Ala Ala Tyr Val Asp Arg Phe Val Arg Ser Leu Pro 85 90 95 Glu Gly Tyr Asp Thr Val Leu Asp Asp Glu Wing Met Asn Leu Ser Val 100 105 110 Gly Glu Arg Gln Leu He Thr He Wing Arg Wing Phe Leu Wing Asn Pro 115 120 125 Arg Leu Leu He Leu Asp Glu Wing Thr Ser Ser Val Asp Thr Arg Thr 130 135 140 Glu Leu Leu He Gln Arg Wing Met Ser Lys Leu Arg Gln Asp Arg Thr 145 150 155 160 Wing Phe Val He Wing His Arg Leu Being Thr He Arg Asp Wing Asn Leu 165 170 175 He Leu Met Met Lys Asp Gly Glu He Val Glu Gln Gly Asn His Arg 180 185 190 Glu Leu Met Wing Leu Glu Gly Wing Tyr Trp Glu Leu Tyr Asn Ser Gln 195 200 205 • Phe Asn Wing Pro Wing Lys Glu Glu Leu Gln Wing Asp Gly Asp His 210 215 220 < 210 > 341 < 211 > 1986 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1963) < 223 > RXA00878 10 < 400 > 341 cgatgatt; agg -tccgcttcag ttgtggtggt 2 tccgaatctg atg; aaca; atg; ateattecta 60 attcatttac; atctttatica aagagageca ccacctacta atg cga ctt ctt ctt • ggt 115 Met Arg Leu Leu Gly 1 5 cga att tta aaa acc acg tet gcg ctt tgg ccc tac tat etc gga att 163 Arg He Leu Lys Thr Thr Ser Wing Leu Trp Pro Tyr Tyr Leu Gly He 10 15 20 ate gtc gta tcc att gtg ate gcg gcg ttg tcg ctg ctg tcg ccg ttt 211 He Val Val Ser He Val He Ala Ala Ala Leu Leu Leu Ser Pro Phe 25 30 35 15 att etc cgc gaa gca here gat tct att gtt tet gca gta acc gga tet 259 He Leu Arg Glu Wing Thr Asp Ser He Val Ser Wing Val Thr Gly Ser 40 45 50 aac acc gtc gat gca gtt act cgc act att att ttc tta gct tta gcc 307 Asn Thr Val Asp Wing Val Thr Arg Thr He He Phe Leu Ala Leu Wing 55 60 65 ctg ttt gtc gca age ttc etc aat acg gtg atg acc aac ate ggt ggc 355 Leu Phe Val Ala Ser Phe Leu Asn Thr Val Met Thr Asn He Gly Gly 70 75 80 85 tac ate ggt gat gtc atg gca tet cgt atg cgc cag att ctg gcc acg 403 Tyr He Gly Asp Val Met Wing r Arg Met Arg Gln He Leu Wing Thr 90 95 100 20 cgc tat tac gca aag ctg ttg gcg ctg ect cag aag tat ttt gat aat 451 Arg Tyr Tyr Ala Lys Leu Leu Ala Leu Pro Gln Lys Tyr Phe Asp Asn 105 110 115 cag gtc acc ggc acc ate gcc cgc ctt gat cga tea ate aac ggc 499 Gln Val Thr Gly Thr He He Wing Arg Leu Asp Arg Ser He Asn Gly 120 125 130 ate acg cag ttc atg cag age ttc tcc aac aac ttc ttc ccc atg etc 547 He Thr Gln Phe Met Gln Ser Phe Ser Asn Asn Phe Phe Pro Met Leu 135 140 145 ate acc atg gtg gca gtg ctg att att tcc gcg att ttc tac tgg ect 595 He Thr Met Val Wing Val Leu He He Wing Wing He Phe Tyr Trp Pro 150 155 160 165 25 ctg gca att ctg ctg gcc atg ttg ttc ccg att tac atg tgg ctg acg 643 * k?, Leu Wing He Leu Leu Wing Met Leu Phe Pro He Tyr Met Trp Leu Thr 170 175 180 gcg ttg here tcg aaa cgc tgg cag aaa tat gag ggc gag aaa aac cat 691 Wing Leu Thr Ser Lys Arg Trp Gln Lys Tyr Glu Gly Glu Lys Asn His 185 190 195 gaa ate gac gtg gct aac ggc cgc ttc gct gag gtt gtc ggc cag gtc 739 Glu He Asp Val Wing Asn Gly Arg Phe Wing Glu Val Val Gly Gln Val 200 205 210 aag gtt gtt aaa tea ttc gtc gca gag acc cgc gag ctg gct gat ttc 787 • Lys Val Val Lys Ser Phe Val Wing Glu Thr Arg Glu Leu Wing Asp Phe 215 220 225 ggt ggg cgt tac ggc aaa here gta gcg att acc cgg ccg cact tc ggt 835 Gly Gly Arg Tyr Gly Lys Thr Val Wing He Thr Arg Pro Gln Ser Gly 230 235 240 245 tgg tgg falls cgc atg gat act etc cgt ggc gcg gca cta aat ate ate Trp Trp His Arg Met Asp Thr Leu Arg Gly Ala Ala Leu Asn He He 250 255 260 ttc ctg gcc att falls ctg ctg att ttc tac cgc acc ttg falls ggc cat 931 Phe Leu Wing He His Leu Leu He Phe Tyr Arg Thr Leu His Gly His 265 270 275 ttc 10 acc ate ggc gac atg gtc atg etc ate cag ctt gtc acc atg gcg 979 Phe- Thr He Gly Asp Met Val Met Leu He Gln Leu Val Thr Met Wing 280 285 290 cag cac ccg gtg tac atg atg age tac ate gtc gac tcc gcg cag cgc 1027 • Gln Gln Pro Val Tyr Met Met Ser Tyr He Val Asp Ser Wing Gln Arg 295 300 305 gcc ate gcc ggc tcc cgc gac tac ttc gag gtc atg gcg cag cag gtc 1075 Wing He Wing Gly Ser Arg Asp Tyr Phe Glu Val Met Wing Gln Gln Val 310 315 320 325 gag ccc acc gcc aat aag gag ctt gtc gac gcc acc etc gcc tea gac 1123 Glu Pro Thr Wing Asn Lys Glu Leu Val Asp Wing Thr Leu Wing As Asp 330 335 340 15 act cca cgc ate agt gtg ggc acg ccc gcc gcg ctg ccc gct gga gaa 1171 Thr Pro Arg He Ser Val Gly Thr Pro Wing Ala Leu Pro Wing Gly Glu 345 350 355 cca gcg atg gaa ttc aaa aac gtc acc ttc gcc tac gaa gag ggc aag 1219 Pro Ala Met Glu Phe Lys Asn Val Thr Phe Wing Tyr Glu Glu Gly Lys 360 365 370 ccg gtt att tcc gac gtg tcc att acc gcc cgc drops ggc gag cgc ate 1267 Pro Val He Ser Asp Val Ser He Thr Wing Arg His Gly Glu Arg He 375 380 385 gcg ttg gtc ggt gaa tcc ggc ggc ggt aaa tcc acc ctg gtc aac ctt 1315 Wing Leu Val Gly Glu Ser Gly Gly Gly Lys Ser Thr Leu Val Asn Leu 390 395 400 405 20 ctg tta ggt ctg tac aa a cca aac age ggc age ctt gca gta tgt ggc 1363 Leu Leu Gly Leu Tyr Lys Pro Asn Ser Gly Ser Leu Wing Val Cys Gly 410 415 420 gtg gat gtt aaa gat ctg act tc gag gaa ctt cgc gca tcc gtg ggt 1411 Val Asp Val Lys Asp Leu Thr Ser Glu Glu Leu Arg Ala Ser Val Gly 425 430 435 gtg gtc gtc cag gac gcc age ttg ttc tet gga tet att gca gaa aac 1459 Val Val Phe Gln Asp Wing Ser Leu Phe Ser Gly Ser He Wing Glu Asn 440 445 450 ate gcc tac ggt cgc cca ggt gcc acc cgc gaa gag ate ate gaa gtg 1507 He Wing Tyr Gly Arg Pro Gly Wing Thr Arg Glu Glu He He Glu Val 455 460 465 25 gct aag aaa gcc aac gca cat gag ttc att tcc gcc ttc ect gaa gga 1555 Wing Lys Lys Wing Asn Wing His Glu Phe He Wing Wing Phe Pro Glu Gly 470 475 480 485 tat gaa acc gtc gtc gtc gag cgc gga etc aaa ctt tet ggt ggc cag 1603 Tyr Glu Thr Val Val Gly Glu Arg Gly Leu Lys Leu Ser Gly Gly Gln 490 495 500 aag cag cgc gtc tet gtg gca cgg gcc atg ctt aaa gat gcc cca ctt 1651 Lys Gln Arg Val Ser Val Ala Arg Wing Met Leu Lys Asp Wing Pro Leu 505 510 515 ctt gtt etc gat gaa gcc acc tet gca ctg gat acc aag tet gag cag 1699 ^^ Leu Val Leu Asp Glu Wing Thr Ser Wing Leu Asp Thr Lys Ser Glu Gln 520 525 530 gca gtc ca gcc ggt ttg gaa cag ctg atg gaa aac cgc acc acc tta 1747 Wing Val Gln Wing Gly Leu Glu Gln Leu Met Glu Asn Arg Thr Thr Leu 535 540 545 atg ate gcc falls cgc ctg tcc acc ate gca ggc gtc gat acc ate gtg 1795 Met He Wing His Arg Leu Ser Thr He Wing Gly Val Asp Thr He Val 550 555 560 565 acc ate caa aac gga cgg gtt gaa ga gtc gga tet ect acc gag etc 1843 Thr He Gln Asn Gly Arg Val Glu Glu Val Gly Ser Pro Thr Glu Leu 570 575 580 gca 10 gtc tea ggc ggt ate tat tcc gaa ctg ctg cgc ctg acc aac tcc 1891 Wing Val Ser Gly Gly He Tyr Ser Glu Leu Leu Arg Leu Thr Asn Ser 585 590 595 here gca gaa gcc gac cgg gag cgt ctg cgc gcc ttt ggt tcc act ggc 1939 Thr Wing Glu Wing Asp Arg Glu Arg Leu Arg Wing Phe Gly Phe Thr Gly 600 605 610 gat gca cca gct gaa gag gac tagccccgcg aaagaacaat ccc 1986 Asp Ala Pro Ala Glu Glu Glu Asp 615 620 < 210 > 342 < 211 > 621 15 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 342 Met Arg Leu Leu Gly Arg He Leu Lys Thr Thr Ser Ala Leu Trp Pro 1 5 10 15 Tyr Tyr Leu Gly He He Val Val Ser He He Val Wing Ala Wing Leu Ser 20 25 30 Leu Leu Ser Pro Phe He Leu Arg Glu Ala Thr Asp Ser He Val Ser 35 40 45 Wing Val Thr Gly Ser Asn Thr Val Asp Wing Val Thr Arg Thr He He 50 55 60 20 Phe Leu Wing Leu Wing Leu Phe Val Wing Being Phe Leu Asn Thr Val Met 65 70 75 80 Thr Asn He Gly Gly Tyr He Gly Asp Val Met Wing Being Arg Met Arg 85 90 95 Gln He Leu Wing Thr Arg Tyr Tyr Wing Lys Leu Leu Wing Leu Pro Gln 100 105 110 Lys Tyr Phe Asp Asn Gln Val Thr Gly Thr He He Wing Arg Leu Asp 115 120 125 Arg Ser He Asn Gly He Thr Gln Phe Met Gln Ser Phe Ser Asn Asn 130 135 140 Phe Phe Pro Met Leu He Thr Met Val Wing Val Leu He He Ser Wing 145 150 155 160 25 He Phe Tyr Trp Pro Leu Ala He Leu Leu Ala Met Leu Phe Pro He 165 170 175 Tyr Met Trp Leu Thr Ala Leu Thr Ser Lys Arg Trp Gln Lys Tyr Glu 180 185 190 Gly Glu Lys Asn His Glu He Asp Val Wing Asn Gly Arg Phe Wing Glu 195 200 205 Val Val Gly Gln Val Lys Val Val Lys Ser Phe Val Wing Glu Thr Arg 210 215 220 Glu Leu Wing Asp Phe Gly Gly Arg Tyr Gly Lys Thr Val Wing He Thr 225 230 235 240 Arg Pro Gln Ser Gly Trp Trp His Arg Met Asp Thr Leu Arg Gly Wing 245 250 255 Ala Leu Asn He He Phe Leu Ala He His Leu Leu He Phe Tyr Arg 260 265 270 Thr Leu His Gly His Phe Thr He Gly Asp Met Val Met Leu He Gln 275 280 285 Leu Val Thr Met Ala Gln Gln Pro Val Tyr Met Met Ser Tyr He Val 290 295 300 Asp Ser Ala Gln Arg Ala He Ala Gly Ser Arg Asp Tyr Phe Glu Val 305 310 315 320 Met Wing Gln Gln Val Glu Pro Thr Wing Asn Lys Glu Leu Val Asp Wing 325 330 335 Thr Leu Wing Being Asp Thr Pro Arg He Ser Val Gly Thr Pro Wing Wing 340 345 350 Leu Pro Wing Gly Glu Pro Wing Met Glu Phe Lys Asn Val Thr Phe Wing 355 360 365 Tyr Glu Glu Gly Lys Pro Val He Ser Asp Val Ser He Thr Ala Arg 370 375 380 His Gly Glu Arg He Wing Leu Val Gly Glu Ser Gly Gly Gly Lys Ser 385 390 395 400 Thr Leu Val Asn Leu Leu Leu Gly Leu Tyr Lys Pro Asn Ser Gly Ser 405 410 415 Leu Wing Val Cys Gly Val Asp Val Lys Asp Leu Thr Ser Glu Glu Leu 420 425 430 Arg Ala Ser Val Gly Val Val Phe Gln Asp Wing Ser Leu Phe Ser Gly 435 440 445 Ser He Wing Glu Asn He Wing Tyr Gly Arg Pro Gly Ala Thr Arg Glu 450 455 460 Glu He He Glu Val Wing Lys Lys Wing Asn Wing His Glu Phe He Ser 465 470 475 480 Wing Phe Pro Glu Gly Tyr Glu Thr Val Val Gly Glu Arg Gly Leu Lys 485 490 495 Leu Ser Gly Gly Gln Lys Gln Arg Val Ser Val Ala Arg Ala Met Leu 500 505 510 Lys Asp Ala Pro Leu Leu Val Leu Asp Glu Ala Thr Ser Ala Leu Asp 515 520 525 Thr Lys Ser Glu Gln Ala Val Gln Ala Gly Leu Glu Gln Leu Met Glu 530 535 540 Asn Arg Thr Thr Leu Met He Wing His Arg Leu Ser Thr He Wing Gly 545 550 555 560 Val Asp Thr He Val Thr He Gln Asn Gly Arg Val Glu Glu Val Gly 565 570 575 Ser Pro Thr Glu Leu Wing Val Ser Gly Gly He Tyr Ser Glu Leu Leu 580 585 590 Arg Leu Thr Asn Ser Thr Wing Glu Wing Asp Arg Glu Arg Leu Arg Wing 595 600 605 Phe Gly Phe Thr Gly Asp Wing Pro Wing Glu Glu Glu Asp 610 615 620 < 210 > 343 < 211 > 1713 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1690) < 223 > RXN01191 < 400 > 343 cgctgctittc < aegeaaettga aaccgcaccg galtcaatgtta ttt! ggggttg 1ttetttgtgg 60 cgtgttggtg < gccgtcgctgg ggttggtagg gct? ctgggcg gtg ggt gga etc gtc 115 Val Gly Gly Leu Val 1 5 gat aag etc ctt gca acc ccg age atg cgc gac gtt gt gtg gtg tcc 163 Asp Lys Leu Leu Wing Thr Pro Ser Met Arg Asp Val Val Val Phe Wing 10 15 20 ctg ctt gtg gctg gct ggc gtt gtt tcg age ctg ggc acg tgg tgg 211 Leu Leu He Val Wing Gly Gly Val Val Ser Ser Leu Gly Thr Trp Trp 25 30 35 ggc age gcg ctg atg gcg cgc gcg ttg gag ccg gcg ate gcg ggg ctg 259 Gly Be Ala Leu Met Ala Ala Arg Ala Leu Glu Pro Ala He Ala Gly Leu 40 45 50 cgc gag gat gtg ttg cgc gcg gcg gtg agt ttg gat gcg aac acg att 307 Arg Glu Asp Val Leu Arg Ala Ala Val Ser Leu Asp Wing Asn Thr He 55 60 65 gaa acg gcg ggg cgc ggc gac gtg att tcg cgt ate gcg gat gat tcg 355 Glu Thr Wing Gly Arg Gly Asp Val He Ser Arg He Wing Asp Asp Ser 70 75 80 85 cgg gag gtg tcc act gcg gcg age acc gtg gtg ccg ctg atg gtg cag 403 Arg Glu Val Ser Thr Wing Wing Ser Thr Val Val Pro Leu Met Val Gln 90 95 100 gcg ggc ttt acc gtg att tcc gcg ttt ggc atg gcg gcg gtt gat 451 Wing Gly Phe Thr Val Val Be Wing Wing Phe Gly Met Wing Wing Val Asp 105 110 115 tgg cgc etc ggc ctt gtc ggt ttg gtc gcg ate ccg ctg tat tgg acc 499 Trp Arg Leu Gly Leu Val Gly Leu Val Wing Pro Pro Leu Tyr Trp Thr 120 125 130 acg ttg cgc gtc tat tta ccc cgc tea ggt ccg ctt tat acg cgt gag 547 Thr Leu Arg Val Tyr Leu Pro Arg Ser Gly Pro Leu Tyr Thr Arg Glu 135 140 145 cgc gag gcc ttt ggg gtg cgc acg cag cgg ctt gtc ggc gca gtc gaa 595 Arg Glu Wing Phe Gly Val Arg Thr Gln Arg Leu Val Gly Wing Val Glu 150 155 160 165 ggc gcg gaa acc ttg cgc gct tcc cgc gca gaa gat here gaa tta aag 643 Gly Wing Glu Thr Leu Arg Ala Phe Arg Ala Glu Asp Thr Glu Leu Lys 170 175 180 cgt ate gac gca gcc tcc ggc gaa gcc cgc gac att tcc att tet gtt 691 Arg He Asp Ala Ala Ser Gly Glu Ala Arg Asp He Ser He Ser Val 185 190 195 ttc agg ttc etc here tgg gc ttt tcc cgc aac aac cgc gcg gaa tgc 739 phe arg phe leu thr trp wing phe be arg asn asn arg ala glu cys 200 205 210 ate acc gtg etc etc ttg ggc ate ggc acc gtc ttt tac ctg gtc aac ate 787 He Thr Leu Val Leu He Leu Gly Thr Gly Phe Tyr Leu Val Asn He -tAJI g ^ j 215 220 225 gat ctg gtc acc gtc ggc gca gtc tea acc gcc gca ctg ate ttc falls 835 Asp Leu Val Thr Val Gly Ala Val Ser Thr Ala Ala Leu He Phe His 230 235 240 245 cga etc ttc ggt cca ate ggc acg etc gtg ggc atg ttc tcc gac ate 883 Arg Leu Phe Gly Pro He Gly Thr Leu Val Gly Met Phe Ser Asp He 250 255 260 cac tcc gcc age gca tcg ctg ate cgc atg gtg ggc gtt att aac gcg 931 • Gln Ser Wing Being Wing Being Leu He Arg Met Val Gly Val He Asn Wing 265 270 275 gca tcg aac cag gtc age ggc acc tcg ccg gcg tet gcc age acc gct 979 Wing Being Asn Gln Val Being Gly Thr Ser Pro Wing Being Wing Being Thr Wing 280 285 290 tta acg ctt ttc gac gtc tcc falls fall tat falls act gca ccc gtc ate 1027 Leu Thr Leu Phe Asp Val Ser His His Tyr His Thr Wing Pro Val He 295 300 305 aag aat gca tcc gtg cag ctg gaa cca ggg gaa cae ate gcc att gtg 1075 Lys Asn Ala Ser Val Gln Leu Glu Pro Gly Glu His He Ala He Val 310 315 320 325 ggt gcg gcg ac ggt ggt aaa age acg etc gcc etc att gcg gca ggc 1123 10 Gly Wing Thr Gly Wing Gly Lys Ser Thr Leu Wing Leu Wing Wing Gly 330 335 340 ctg etc age cca act tcc ggg cag gtg gct etc ggc gga tcg agt ttt 1171 Leu Leu Ser Pro Thr Ser Gly Gln Val Wing Leu Gly Gly Ser Ser Phe 345 350 355 tet aac gtc gaa ccg gaa gca ttg cgc cag aag ate gcg atg gtc age 1219 Ser Asn Val Glu Pro Glu Ala Leu Arg Gln Lys He Wing Met Val Ser 360 365 370 caa gaa ate falls tgc ttc cga gga tet gtt tta gat aat ctt cgt ate 1267 Gln Glu He His Cys Phe Arg Gly Ser Val Leu Asp Asn Leu Arg He 375 380 385 gca cgc ccc gaa gcc acc gat gcg gac ate drops gcc gtt etc gcc gat 1315 15 Wing Arg Pro Glu Wing Thr Asp Wing Asp He His Wing Val Leu Wing Asp 390 395 400 405 att ggt gat tcc tgg ttg gag cgc tta ccg ca ggc ata gac acc ate 1363 He Gly Asp Ser Trp Leu Glu Arg Leu Pro Gln Gly He Asp Thr He 410 415 420 gtg ggt gat ggc gct ttc cgt tta acc tet gtg gaa aac cag ate atg 1411 Val Gly Asp Gly Wing Phe Arg Leu Thr Ser Val Glu Asn Gln He Met 425 430 435 gcg ctt gct cgc gta cat ttg gcc gac cta gca ate gtc ate ctt gat 1459 Ala Leu Ala Arg Val His Leu Ala Asp Leu Ala He Val He Leu Asp 440 445 450 gaa gca acg gct gaa tea ggc tet gat cat gca aaa cag ctt gaa gat 1507 20 Glu Ala Thr Ala Glu Ser Gly Ser Asp His Wing Lys Gln Leu Glu Asp 455 460 465 gca gcc ctt aaa gtc act gaa aac aga tea gcc ate ate gtg gct cae 1555 Wing Wing Leu Lys Val Thr Glu Asn Arg Wing Wing He He Wing Val Wing His 470 475 480 485 cgc etc aac gcg gcg aaa acc gcc gat cgc ate ate gtc atg gac tcc 1603 Arg Leu Asn Gln Wing Lys Thr Wing Asp Arg He He Val Met Asp Ser 490 495 500 gga gaa ate ata gaa tet gga acc cat gaa gag ctt cga gcg ate ggc 1651 Gly Glu He He Glu Be Gly Thr His Glu Glu Leu Arg Wing He Gly 505 510 515 ggc cga tat gaa caa ctg tgg act gcg tgg tet gcg cgc taattageca 1700 25 Gly Arg Tyr Glu Gln Leu Trp Thr Wing Trp Ser Wing Arg 520 525 530 cccaagacca cgc 1713 < 210 > 344 < 211 > 530 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 344 • Val Gly Gly Leu Val Asp Lys Leu Leu Wing Thr Pro Ser Met Arg Asp 1 5 10 15 Val Val Val Phe Ala Leu Leu He Val Wing Gly Gly Val Val Ser Ser 20 25 30 Leu Gly Thr Trp Trp Gly Ser Ala Leu Met Ala Arg Ala Leu Glu Pro 35 40 45 Wing He Wing Gly Leu Arg Glu Asp Val Leu Arg Wing Wing Val Ser Leu 50 55 60 Asp Wing Asn Thr He Glu Thr Wing Gly Arg Gly Asp Val He Ser Arg 65 70 75 80 He Wing Asp Asp Ser Arg Glu Val Ser Thr Wing Wing Ser Thr Val Val 10 85 90 95 Pro Leu Met Val Gln Wing Gly Phe Thr Val Val Wing Ser Wing Phe Gly 100 105 110 Met Wing Wing Val Asp Trp Arg Leu Gly Leu Val Gly Leu Val Ala He • 115 120 125 Pro Leu Tyr Trp Thr Thr Leu Arg Val Tyr Leu Pro Arg Ser Gly Pro 130 135 140 Leu Tyr Thr Arg Glu Arg Glu Wing Phe Gly Val Arg Thr Gln Arg Leu 145 150 155 160 Val Gly Ala Val Glu Gly Wing Glu Wing Thr Leu Arg Wing Phe Arg Wing Glu 165 170 175 Asp Thr Glu Leu Lys Arg He Asp Wing Wing Ser Gly Glu Wing Arg Asp 15 180 185 190 Be Ser Be Val Phe Arg Phe Leu Thr Trp Wing Phe Ser Arg Asn 195 200 205 Asn Arg Ala Glu Cys He Thr Leu Val Leu He Leu Gly Thr Gly Phe 210 215 220 Tyr Leu Val Asn He Asp Leu Val Thr Val Gly Wing Val Ser Thr Wing 225 230 235 240 Wing Leu He Phe His Arg Leu Phe Gly Pro He Gly Thr Leu Val Gly 245 250 255 Met Phe Ser Asp He Gln Ser Wing Being Wing Being Leu He Arg Met Val 260 265 270 Gly Val He Asn Wing Wing Being Asn Gln Val Ser Gly Thr Ser Pro Wing 20 275 280 285 Being Wing Being Thr Wing Leu Thr Leu Phe Asp Val Ser His His Tyr His 290 295 300 Thr Wing Pro Val He Lys Asn Wing Ser Val Gln Leu Glu Pro Gly Glu 305 310 315 320 His He Wing He Wing Val Gly Wing Thr Gly Wing Gly Lys Ser Thr Leu Wing 325 330 335 Leu He Ala Ala Gly Leu Leu Ser Pro Thr Ser Gly Gln Val Ala Leu 340 345 350 Gly Gly Ser Ser Phe Ser Asn Val Glu Pro Glu Ala Leu Arg Gln Lys 355 360 365 He Wing Met Val Ser Gln Glu He His Cys Phe Arg Gly Ser Val Leu 25 370 375 380 A ij J.ÍÍ Asp Asn Leu Arg He Wing Arg Pro Glu Wing Thr Asp Wing Asp He His 385 390 395 400 Wing Val Leu Wing Asp He Gly Asp Ser Trp Leu Glu Arg Leu Pro Gln 405 410 415 Gly He Asp Thr He Val Gly Asp Gly Wing Phe Arg Leu Thr Ser Val 420 425 430 Glu Asn Gln He Met Ala Leu Ala Arg Val His Leu Wing Asp Leu Wing 435 440 445 • He Val He Leu Asp Glu Wing Thr Wing Glu Ser Gly Ser Asp His Wing 450 455 460 Lys Gln Leu Glu Asp Wing Wing Leu Lys Val Thr Glu Asn Arg Ser Wing 465 470 475 480 He He Val Wing His Arg Leu Asn Gln Wing Lys Thr Wing Asp Arg He 485 490 495 He Val Met Asp Ser Gly Glu He He Glu Be Gly Thr His Glu Glu 500 505 510 Leu Arg Wing He Gly Gly Arg Tyr Glu Gln Leu Trp Thr Wing Trp Ser 515 520 525 Wing Arg 530 10 < 210 > 345 < 211 > 1430 < 212 > DNA • < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (1407) < 223 > FRXA0H91 < 400 > 345 15 gtg agt ttg gat gcg aac acg att gaa acg gcg ggg cgc ggc gac gtg 48 Val Ser Leu Asp Wing Asn Thr He Glu Thr Wing Gly Arg Gly Asp Val 1 5 10 15 att tcg cgt ate gcg gat gat tcg cgg gag gtg tcc act gcg gcg age 96 He Ser Arg He Wing Asp Asp Ser Arg Glu Val Ser Thr Wing Wing Ser 20 25 30 gtg gtg ccg ctg atg gtg cag gcg ggc ttt acc gtg gtg att tcc 144 Thr Val Val Pro Leu Met Val Gln Wing Gly Phe Thr Val Val He Ser 35 40 45 gcg ttt ggc atg gcg gcg gtt gat tgg cgc etc ggc ctt gtc ggt ttg 192 Wing Phe Gly Met Wing Wing Val Asp Trp Arg Leu Gly Leu Val Gly Leu 50 55 60 20 gtc gcg ate ccg ctg tat tgg acc acg ttg cgc gtc tat tta ccc cgc 240 Val Ala He Pro Leu Tyr Trp Thr Thr Leu Arg Val Tyr Leu Pro Arg 65 70 75 80 tea ggt ccg ctt tat acg cgt gag cgc gag gcc ttt ggg gtg cgc acg 288 Ser Gly Pro Leu Tyr Thr Arg Glu Arg Glu Wing Phe Gly Val Arg Thr 85 90 95 cag cgg ctt gtc ggc gca gtc gaa ggc gcg gaa acc ttg cgc gct ttc 336 Gln Arg Leu Val Gly Wing Val Glu Gly Wing Glu Thr Leu Arg Wing Phe 100 105 110 cgc gca gaa gat here gaa tta aag cgt ate gac gca gcc tcc ggc gaa 384 Arg Ala Glu Asp Thr Glu Leu Lys Arg He Asp Wing Wing Ser Gly Glu 115 120 125 25 gcc cgc gac att tcc att tet gtt ttc agg ttc etc here tgg gca ttt 432 Wing Arg Asp He Ser Be Ser Val Phe Arg Phe Leu Thr Trp Wing Phe 130 135 140 tcc cgc aac aac cgc gcg gaa tgc ate acc gtg etc. etc ttg ggc 480 Ser Arg Asn Asn Arg Ala Glu Cys He Thr Leu Val Leu He Leu Gly 145 150 155 160 acc ggc ttt tac ctg gtc aac ate gat ctg gtc acc gtc gcc gca gcc 528 Thr Gly Phe Tyr Leu Val Asn He Asp Leu Val Thr Val Gly Wing Val 165 170 175 tea acc gcc gca ctg ate ttc cca cga etc ct tc ggt ate ggc acg 576 • Be Thr Ala Ala Leu He Phe His Arg Leu Phe Gly Pro He Gly Thr 180 185 190 etc gtg ggc atg ttc tcc gac ate cac tcc gcc age gca tcg ctg ate 624 Leu Val Gly Met Phe Ser Asp He Gln Ser Ala Ala Ser Leu He 195 200 205 cgc atg gtg ggc gtt att aac gcg gca tcg aac cag gtc age ggc acc 672 Arg Met Val Gly Val He Asn Ala Wing As As Gln Val Ser Gly Thr 210 215 220 tcg ccg gcg tet gcc age acc gct tta acg ctt ttc gac gtc tcc falls 720 Ser Pro Wing Ser Wing Ser Thr Wing Leu Thr Leu Phe Asp Val Ser His 225 230 235 240 10 fall tat fall act gca ccc gtc ate aag aat gca ct gtg cag ctg gaa 768 His Tyr His Thr Ala Pro Val He Lys Asn Ala Ser Val Gln Leu Glu 245 250 255 cca ggg gaa cae ate gcc att gtg ggt gcg acc ggc gct ggt aaa age 816 • Pro Gly Glu His He Wing He Val Gly Wing Thr Gly Wing Gly Lys Ser 260 265 270 acg etc gcc etc att gcg gca ggc ctg etc age cca act tcc ggg cag 864 Thr Leu Wing Leu He Wing Wing Gly Leu Leu Ser Pro Thr Be Gly Gln 275 280 285 gtg gct etc ggc gga tcg agt ttt tet aac gtc gaa ccg gaa gca ttg 912 Val Ala Leu Gly Gly Ser Ser Phe Ser Asn Val Glu Pro Glu Ala Leu 290 295 300 15 cgc cag aag ate gcg atg gtc age caa gaa ate falls tgc ttc cga gga 960 Arg Gln Lys He Wing Met Val Ser Gln Glu He His Cys Phe Arg Gly 305 310 315 320 tet gtt tta gat aat ctt cgt ate gca cgc ccc gaa gcc acc gat gcg 1008 Ser Val Leu Asp Asn Leu Arg He Wing Arg Pro Glu Wing Thr Asp Wing 325 330 335 gac ate fall gcc gtt etc gcc gat att ggt gat tcc tgg tg gag cgc 1056 Asp He His Wing Val Leu Wing Asp He Gly Asp Ser Trp Leu Glu Arg 340 345 350 tta ccg ca ggc ata gac acc ate gtg ggt gat ggc gct ttc cgt tta 1104 Leu Pro Gln Gly He Asp Thr He Val Gly Asp Gly Wing Phe Arg Leu 355 360 365 20 acc tet gtg gaa aac cag ate atg gcg ctt gct cgc gta cat ttg gcc 1152 Thr Ser Val Glu Asn Gln He Met Wing Leu Wing Arg Val His Leu Wing 370 375 380 gac cta gca ate gtc ate ctt gat gaa gca acg gct gaa tea ggc tet 1200 Asp Leu Wing He Val He Leu Asp Glu Wing Thr Wing Glu Ser Gly Ser 385 390 395 400 gat cat gca aaa cag ctt gaa gat gca gcc ctt aaa gtc act gaa aac 1248 Asp His Wing Lys Gln Leu Glu Asp Wing Wing Leu Lys Val Thr Glu Asn 405 410 415 aga tea gcc ate ate gtg gct gct falls cgc etc aac ca gcg gcg aaa acc gcc 1296 Arg Being Wing He He Val Val Wing His Arg Leu Asn Gln Wing Lys Thr Wing 420 425 430 25 gat cgc ate ate gtc atg gac tcc gga gaa ate ata gaa tet gga acc 1344 - • * * - 1¡ ML Asp Arg He He Val Met Asp Ser Gly Glu He He Glu Ser Gly Thr 435 440 445 cat gaa gag ctt cga gcg ate ggc ggt cga tat gaa caa ctg tgg act 1392 His Glu Glu Leu Arg Ala He Gly Gly Arg Tyr Glu Gln Leu Trp Thr 450 455 460 gcg tgg tet gcg cgc taattageca cccaagacca cgc 1430 Wing Trp Ser Wing Arg 465 • < 210 > 346 < 211 > 469 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 346 Val Ser Leu Asp Wing Asn Thr He Glu Thr Wing Gly Arg Gly Asp Val 1 5 10 15 He Ser Arg He Wing Asp Asp Ser Arg Glu Val Ser Thr Wing Wing Ser 20 25 30 Thr Val Val Pro Leu Met Val Gln Wing Gly Phe Thr Val Val He Ser 10 35 40 45 Wing Phe Gly Met Wing Wing Val Asp Trp Arg Leu Gly Leu Val Gly Leu 50 55 60 Val Wing Pro Pro Leu Tyr Trp Thr Thr Leu Arg Val Tyr Leu Pro Arg 65 70 75 80 Ser Gly Pro Leu Tyr Thr Arg Glu Arg Glu Wing Phe Gly Val Arg Thr 85 90 95 Gln Arg Leu Val Gly Wing Val Glu Gly Wing Glu Thr Leu Arg Wing Phe 100 105 110 Arg Wing Glu Asp Thr Glu Leu Lys Arg He Asp Wing Wing Ser Gly Glu 115 120 125 Wing Arg Asp He Ser Be Ser Val Phe Arg Phe Leu Thr Trp Wing Phe 15 130 135 140 Ser Arg Asn Asn Arg Wing Glu Cys He Thr Leu Val Leu He Leu Gly 145 150 155 160 Thr Gly Phe Tyr Leu Val Asn He Asp Leu Val Thr Val Gly Ala Val 165 170 175 Ser Thr Ala Ala Leu He Phe His Arg Leu Phe Gly Pro He Gly Thr 180 185 190 Leu Val Gly Met Phe Ser Asp He Gln Ser Ala Ser Ala Ser Leu He # 195 200 205 Arg Met Val Gly Val He Asn Ala Ala Ser Asn Gln Val Ser Gly Thr 210 215 220 Ser Pro Ala Ser Ala Ser Thr Ala Leu Thr Leu Phe Asp Val Ser His 20 225 230 235 240 His Tyr His Thr Ala Pro Val He Lys Asn Ala Ser Val Gln Leu Glu 245 250 255 Pro Gly Glu His He Ala He Val Gly Ala Thr Gly Ala Gly Lys Ser 260 265 270 Thr Leu Ala Leu He Ala Ala Gly Leu Leu Ser Pro Thr Ser Gly Gln 275 280 285 Val Ala Leu Gly Gly Ser Ser Phe Ser Asn Val Glu Pro Glu Ala Leu 290 295 300 Arg Gln Lys He Wing Met Val Ser Gln Glu He His Cys Phe Arg Gly 305 310 315 320 Ser Val Leu Asp Asn Leu Arg He Wing Arg Pro Glu Wing Thr Asp Ala 25 325 330 335 Asp He His Wing Val Leu Wing Asp He Gly Asp Ser Trp Leu Glu Arg 340 345 350 Leu Pro Gln Gly He Asp Thr He Val Gly Asp Gly Wing Phe Arg Leu 355 360 365 Thr Ser Val Glu Asn Gln He Met Wing Ala Leu Wing Arg Val His Leu Wing 370 375 380 Asp Leu Wing He Le Val He Leu Asp Glu Wing Thr Wing Glu Ser Gly Ser 385 390 395 400 Asp His Wing Lys Gln Leu Glu Asp Wing Wing Leu Lys Val Thr Glu Asn • 405 410 415 Arg Wing He He Val Wing His Arg Leu Asn Gln Wing Lys Thr Wing 420 425 430 Asp Arg He He Val Met Asp Ser Gly Glu He He Glu Ser Gly Thr 435 440 445 His Glu Glu Leu Arg Wing He Gly Gly Arg Tyr Glu Gln Leu Trp Thr 450 455 460 Ala Trp Ser Ala Arg 465 < 210 > 347 10 < 211 > 1047 < 212 > DNA < 213 > Corynebacterium glutamicum • < 220 > < 221 > CDS < 222 > (101) .. (1024) < 223 > RXN01212 < 400 > 347 tttagaagee acatgacata tgtcatgaaa attatgtgca aagtgcagta atactcctga 60 catatggctc taccagcgcc aatgcgaagt aggaagaatt atg ect atg ac ac 115 15 Met Pro Met Thr Thr 1 5 here cca gca ate gac gta here gac etc gtg aga acc tac ggc gac tac 163 Thr Pro Ala He Asp Val Thr Asp Leu Val Arg Thr Tyr Gly Asp Tyr 10 15 20 acc gca gtc aag ggc ctg aat ttc cat gta cag cgc ggt gaa gta ttt 211 Thr Wing Val Lys Gly Leu Asn Phe His Val Gln Arg Gly Glu Val Phe 25 30 35 ggt ctg etc ggc acc aac ggg gcc ggc aaa acc tcc acc ttg gaa gtc 259 • Gly Leu Leu Gly Thr Asn Gly Wing Gly Lys Thr Ser Thr Leu Glu Val 40 45 50 ate gaa gga ctt tcc gca ccc age tcc ggc acc gtg cgc ate tcc ggg 307 20 He Glu Gly Leu Ser Wing Pro Ser Gly Thr Val Arg He Ser Gly 55 60 65 ctt gac ccc gtt gcc gac cgc gcg ate ctc cgc ccc gag etc ggc ate 355 Leu Asp Pro Val Wing Asp Arg Ala He Leu Arg Pro Glu Leu Gly He 70 75 80 85 atg ctg caa tea ggc ggc ctg cca tea cag etc acc gtc gcc gaa acc 403 Met Leu Gln Ser Gly Glu Leu Pro Ser Gln Leu Thr Val Ala Glu Thr 90 95 100 atg gac atg tgg falls ggc acc tgc acg tat ccg cgc gcc att aaa gat 451 Met Asp Met Trp His Gly Thr Cys Thr Tyr Pro Arg Wing He Lys Asp 105 110 115 gtg ctt gcc gac gtc gac etc cta cgc gaa aac gtc aag gtc ggc 499 25 Val Leu Ala Asp Val Asp Leu Leu His Arg Glu Asn Val Lys Val Gly 120 125 130 gcg ctt tcc gga ggc gaa caga cga cgc ctt gat ttg gcc tgc gca ctg 547 Wing Leu Ser Gly Gly Glu Gln Arg Arg Leu Asp Leu Wing Cys Wing Leu 135 140 145 ctt ggc gac ccc tea att ttg ttc etc gac gaa ccc ac acc ggc etc 595 Leu Gly Asp Pro Be He Leu Phe Leu Asp Glu Pro Thr Thr Gly Leu 150 155 160 165 gac cca gaa tet agg cgc falls acc tgg ca a ctg ctg gac ctg aaa 643 Asp Pro Glu Be Arg Arg His Thr Trp Gln Leu Leu Leu Asp Leu Lys • 170 175 180 cag cgc ggc gtc acc atg atg ctg acc accu falls tac ctg gag gaa gcc 691 Gln Arg Gly Val Thr Met Met Leu Thr Thr His Tyr Leu Glu Glu Wing 185 190 195 gaa ttc etc tgc gac cgg att gcc ate atg aac gcc ggt gag ate gca 739 Glu Phe Leu Cys Asp Arg He Wing He Met Asn Wing Gly Glu He Wing 200 205 210 gtg gaa ggc acc ttg gat gaa ctg gtg gcc cgc gag aag tcg ate ate 787 Val Glu Gly Thr Leu Asp Glu Leu Val Wing Arg Glu Lys Ser He He 215 220 225 agt ttc gtg ctg cgt ggc ggg cag gtg gag ttg ccg gtc ttg agt ggg 835 10 Be Phe Val Leu Arg Gly Gly Gln Val Glu Leu Pro Val Leu Ser Gly 230 235 240 245 gct gaa ate ate cgc gac aac aac fall gtc cgc ate gcc acc acc acc 883 Wing Glu He He Arg Asp Asn Asn His Val Arg • He Wing Thr Thr Thr 250 255 260 ctg cag cag falls acc tta gaa ata ctt acc tgg gct gca gag acc ggg 931 Leu Gln Gln His Thr Leu Glu He Leu Thr Trp Wing Wing Glu Thr Gly 265 270 275 ate gcg ctg gaa ggc ttc gct gca aaa ccc gcc acc ttg gaa tcc gta 979 He has Ala Leu Glu Gly Phe Wing Wing Lys Pro Wing Thr Leu Glu Ser Val 280 285 290 ttc atg gac ate gcc tea etc gag aac acc tcg ctg caa acc gcc 1024 15 Phe Met Asp He Wing Ser Leu Glu Asn Thr Ser Leu Gln Thr Wing 295 300 305 tagalatettt aaggaigacca ca 1047 < 210 > 348 < 211 > 308 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 348 Met Pro Met Thr Thr Thr Pro Wing Asp Val Thr Asp Leu Val Arg 1 5 10 15 20 Thr Tyr Gly Asp Tyr Thr Wing Val Lys Gly Leu Asn Phe His Val Gln 20 25 30 Arg Gly Glu Val Phe Gly Leu Leu Gly Thr Asn Gly Wing Gly Lys Thr 35 40 45 Ser Thr Leu Glu Val He Glu Gly Leu Ser Wing Pro Ser Ser Gly Thr 50 55 60 Val Arg He Ser Gly Leu Asp Pro Val Wing Asp Arg Wing He Leu Arg 65 70 75 80 Pro Glu Leu Gly He Met Leu Gln Ser Gly Gly Leu Pro Ser Gln Leu 85 90 95 Thr Val Wing Glu Thr Met Asp Met Trp His Gly Thr Cys Thr Tyr Pro 100 105 110 25 Arg Wing He Lys Asp Val Leu Wing Asp Val Asp Leu Leu His Arg Glu 115 120 125 Asn Val Lys Val Gly Ala Leu Ser Gly Gly Glu Gln Arg Arg Leu Asp 130 135 140 Leu Ala Cys Ala Leu Leu Gly Asp Pro Ser He Leu Phe Leu Asp Glu 145 150 155 160 Pro Thr Thr Gly Leu Asp Pro Glu Ser Arg Arg His Thr Trp Gln Leu 165 170 175 Leu Leu Asp Leu Lys Gln Arg Gly Val Thr Met Met Leu Thr Thr His • 180 185 190 Tyr Leu Glu Glu Wing Glu Phe Leu Cys Asp Arg He Wing He Met Asn 195 200 205 Wing Gly Glu He Wing Val Glu Gly Thr Leu Asp Glu Leu Val Wing Arg 210 215 220 Glu Lys Ser He He Ser Phe Val Leu Arg Gly Gly Gln Val Glu Leu 225 230 235 240 Pro Val Leu Ser Gly Wing Glu He He Arg Asp Asn Asn His Val Arg 245 250 255 He Ala Thr Thr Leu Gln Gln His Thr Leu Glu He Leu Thr Trp 260 265 270 Wing Wing Glu Thr Gly He Wing Wing Leu Glu Gly Phe Wing Wing Lys Pro Wing 10 275 280 285 Thr Leu Glu Ser Val Phe Met Asp He Wing Ser Leu Glu Asn Thr Ser 290 295 300 • Leu Gln Thr Wing 305 < 210 > 349 < 211 > 813 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS 15 < 222 > (1) .. (813) < 223 > FRXA01212 < 400 > 349 ggc ctg aat ttc cat gta cag cgc ggt gaa gta ttt ggt ctg etc ggc 48 Gly Leu Asn Phe His Val Gln Arg Gly Glu Val Phe Gly Leu Leu Gly 1 5 10 15 ac aac ggg gcg gcc aaa acctcc acc ttg gaa gtc ate gaa gga ctt 96 Thr Asn Gly Wing Gly Lys Thr Ser Thr Leu Glu Val He Glu Gly Leu 20 25 30 tcc gca ccc age tcc ggc acc gtg cgc ate tcc ggg ctt gac ccc gtt 144 Be 20 Wing Pro Be Ser Gly Thr Val Arg Be Ser Gly Leu Asp Pro Val 35 40 45 gcc gac cgc gcg ate ctc cgc ccc gag etc ggc ate atg ctg caa tea 192 Wing Asp Arg Wing He Leu Arg Pro Glu Leu Gly He Met Leu Gln Ser 50 55 60 ggc ggc ctg cca tea cag etc acc gtc gcc gaa acc atg gac atg tgg 240 Gly Gly Leu Pro Ser Gln Leu Thr Val Wing Glu Thr Met Asp Met Trp 65 70 75 80 falls ggc acc tgc acg tat ccg cgc gcc att aaa gat gtg ctt gcc gac 288 His Gly Thr Cys Thr Tyr Pro Arg Wing He Lys Asp Val Leu Wing Asp 85 90 95 gtc gac etc cta cgc gaa aac gtc aag gtc ggc gcg ctt tcc gga 336 25 Val Asp Leu Leu His Arg Glu Asn Val Lys Val Gly Ala Leu Ser Gly ÍU. * A ± A. * UUl 4l. *. R *. 4 ^^ Axm ^^ ^ É 100 105 110 ggc gaa caga cga cgc ctt gat ttg gcc tgc gca ctg ctt ggc gac ccc 384 Gly Glu Gln Arg Arg Leu Asp Leu Wing Cys Wing Leu Leu Gly Asp Pro 115 120 125 tea att ttg ttc etc gac gaa ccc ac acc ggc etc gac cca gaa tet 432 Be He Leu Phe Leu Asp Glu Pro Thr Thr Gly Leu Asp Pro Glu Ser 130 135 140 agg cgc falls acc tgg caa etc ctg ctg gac ctg aaa cag cgc ggc gtc 480 Arg Arg His Thr Trp Gln Leu Leu Leu Asp Leu Lys Gln Arg Gly Val 145 150 155 160 acc atg ctg acc acc falls tac ctg gag gaa gcc gaa ttc etc tgc 528 Thr Met Met Leu Thr Thr His Tyr Leu Glu Glu Wing Glu Phe Leu Cys 165 170 175 gac cgg att gcc ate atg aac gcc ggt gag ate gca gtg gaa ggc acc 576 Asp Arg He Wing He Met Asn Wing Gly Glu He Wing Val Glu Gly Thr 180 185 190 ttg gat gaa ctg gtg gcc cgc gag aag tcg ate ate agt ttc gtg ctg 624 Leu Asp Glu Leu Val Wing Arg Glu Lys Ser He He Ser Phe Val Leu 195 200 205 cgt ggc ggg cag gtg gag ttg ccg gtc ttg agt ggg gct gaa ate ate 672 Arg Gly Gly Gln Val Glu Leu Pro Val Leu Ser Gly Wing Glu He He 210 215 220 cgc gac aac aac falls gtc cgc gcc ate acc acc acc ctg cag cag falls 720 Arg Asp Asn Asn His Val Arg He Wing Thr Thr Thr Leu Gln Gln His 225 230 235 240 acc tta gaa ata ctt acc tgg gct gca gag acc ggg ate gcg ctg gaa 768 Thr Leu Glu He Leu Thr Trp Wing Wing Glu Thr Gly He Wing Leu Glu 245 250 255 ggc ttc gct gca aaa ccc gcc acc ttg gaa tcc gta ttc atg gac 813 Gly Phe Ala Ala Lys Pro Ala Thr Leu Glu Ser Val Phe Met Asp 260 265 270 < 210 > 350 < 211 > 271 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 350 Gly Leu Asn Phe His Val Gln Arg Gly Glu Val Phe Gly Leu Leu Gly 1 5 10 15 Thr Asn Gly Wing Gly Lys Thr Ser Thr Leu Glu Val He Glu Gly Leu 20 25 30 Ser Ala Pro Ser Ser Gly Thr Val Arg He Ser Gly Leu Asp Pro Val 35 40 45 Wing Asp Arg Wing He Leu Arg Pro Glu Leu Gly He Met Leu Gln Ser 50 55 60 Gly Gly Leu Pro Ser Gln Leu Thr Val Wing Glu Thr Met Asp Met Trp 65 70 75 80 His Gly Thr Cys Thr Tyr Pro Arg Wing He Lys Asp Val Leu Wing Asp 85 90 95 Val Asp Leu Leu His Arg Glu Asn Val Lys Val Gly Ala Leu Ser Gly 100 105 110 Gly Glu Gln Arg Arg Leu Asp Leu Ala Cys Ala Leu Leu Gly Asp Pro 115 120 125 Be He Leu Phe Leu Asp Glu Pro Thr Thr Gly Leu Asp Pro Glu Ser 130 135 140 Arg Arg His Thr Trp Gln Leu Leu Leu Asp Leu Lys Gln Arg Gly Val tai i.a. _i -i..i 145 150 155 160 Thr Met Met Leu Thr Thr His Tyr Leu Glu Glu Wing Glu Phe Leu Cys 165 170 175 Asp Arg He Wing He Met Asn Wing Gly Glu He Wing Val Glu Gly Thr 180 185 190 Leu Asp Glu Leu Val Wing Arg Glu Lys Ser He He Ser Phe Val Leu 195 200 205 Wing Glu He He Leu Gln Gln His 225 230 235 240 Thr Leu Glu He Leu Thr Trp Wing Wing Glu Thr Gly He Wing Leu Glu 245 250 255 Gly Phe Ala Ala Lys Pro Ala Thr Leu Glu Ser Val Phe Met Asp 260 265 270 < 210 > 351 < 211 > 999 < 212 > DNA < 213 > Corynebacterium glutamicum 10 < 220 > < 400 > 351 caacctaigac 1ttcggtaatga acgtaaictttg ctttagttgg tcggcgcatc; actttcccta 60 agcgatgcgc tcgattacttg tttttgctac aaatttaact atg tea ccc ate cta 115 Met Ser Pro He Leu 1 5 aaa gtg cgg gac etc gtc aaa cgc tat ggc gac acc gtt gcg gtt gac 163 15 Lys Val Arg Asp Leu Val Lys Arg Tyr Gly Asp Thr Val Wing Val Asp 10 15 20 ggt tta aat ttt gat gtt tea ca ggg gaa att ttt gcc ttt cta ggg 211 Gly Leu Asn Phe Asp Val Ser Gln Gly Glu He Phe Wing Phe Leu Gly 25 30 35 gag aac ggc gca gga aaa here acc acg att tea tgc ctg att ggc att 259 Glu Asn Gly Wing Gly Lys Thr Thr Thr He Ser Cys Leu He Gly He 40 45 50 gat ca gcc acc tet ggg gag ate gaa ctg cag ggt ggc ca gta gat 307 Asp Gln Wing Thr Ser Gly Glu He Glu Leu Gln Gly Gly Gln Val Asp 55 60 65 tet gaa aaa ctt gga gtg gtg ttt caca cact tcc gtc tta gac ect ttg 355 Be 20 Glu Lys Leu Gly Val Val Phe Gln Gln Ser Val Leu Asp Pro Leu 70 75 80 85 ctg agt gcc aaa gaa aac ttg gaa here cgc gga cag ctg tac cca ggg 403 Leu Be Wing Lys Glu Asn Leu Glu Thr Arg Gly Gln Leu Tyr Pro Gly 90 95 100 gtg ggg aag cag cgg gtt gca cag etc att gag caa ate ggg atg gaa 451 Val Gly Lys Gln Arg Val Wing Gln Leu He Glu Gln He Gly Met Glu 105 110 115 ggg ttt gcg gac cgc cga tac gga gtg ttg tcg ggc ggt gaa aaa cgt 499 Gly Phe Wing Asp Arg Arg Tyr Gly Val Leu Ser Gly Gly Glu Lys Arg 120 125 130 cgc acc gac ate gca cga gct tta ctg falls age cca gac att ctt ttt 547 25 Arg Thr Asp He Ala Arg Ala Leu Leu His Ser Pro Asp He Leu Phe fc * A »A dfc d dbt *., 135 140 145 ctt gat gaa ccc here gca ggc etc gac ccc aga tea cga cgc ca gtt 595 Leu Asp Glu Pro Thr Wing Gly Leu Asp Pro Arg Ser Arg Arg Gln Val 150 155 160 165 tgg gac acc ate aat tcc ctg cgt aac gtc gcg gcc etc act gtc ttt 643 Trp Asp Thr He Asn Ser Leu Arg Asn Asp Val Gly Leu Thr Val Phe 170 175 180 ttg acc act falls tac atg gaa gaa here gaa ctg gct gat tea gtt cta 691 Leu Thr Thr His Tyr Met Glu Glu Thr Glu Leu Wing Asp Ser Val Leu 185 190 195 ate att gac cgt ggc aaa gag gtc gca tea gga acc ccg atg gaa ctg 739 He He Asp Arg Gly Lys Glu Val Wing Ser Gly Thr Pro Met Glu Leu 200 205 210 cgc gcc cgt tac ac here gaa ttg act ctt aga aac aac gac ect 787 Arg Ala Arg Tyr Thr Thr Thr Glu Leu Thr Leu Arg Thr Asn Asp Pro '215 220 225 act cat tcg ggt aaa gag ttg gcc falls ttg age cca gaa ate gac ggt 835 Thr His Ser Gly Lys Glu Leu Wing His Leu Ser Pro Glu He Asp Gly 230 235 240 245 gac cga ctg cgg ate aag ttg gaa aat ggg etc gaa gct gcg cgc ctg 883 Asp Arg Leu Arg He Lys Leu Glu Asn Gly Leu Glu Wing Wing Arg Leu 250 255 260 gca here gaa cta gat ggg gtt etc gac gta gag ate cgc fall ggt tcc 931 Wing Thr Glu Leu Asp Gly Val Leu Asp Val Glu He Arg His Gly Ser 265 270 275 atg gac gat gta ttt cta gca gtt here gct gaa cgg aaa cga tea 976 Met Asp Asp Val Phe Leu Wing Val Thr Wing Glu Arg Lys Arg Ser 280 285 290 tgattacagt tctgacacgc aga 999 < 210 > 352 < 211 > 292 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 352 Met Ser Pro He Leu Lys Val Arg Asp Leu Val Lys Arg Tyr Gly Asp 1 5 10 15 Thr Val Wing Val Asp Gly Leu Asn Phe Asp Val Ser Gln Gly Glu He 20 25 30 Phe Wing Phe Leu Gly Glu Asn Gly Wing Gly Lys Thr Thr Thr He Ser 35 40 45 Cys Leu He Gly He Asp Gln Wing Thr Ser Gly Glu He Glu Leu Gln 50 55 60 Gly Gly Gln Val Asp Ser Glu Lys Leu Gly Val Val Phe Gln Gln Ser 65 70 75 80 Val Leu Asp Pro Leu Leu Be Wing Lys Glu Asn Leu Glu Thr Arg Gly 85 90 95 Gln Leu Tyr Pro Gly Val Gly Lys Gln Arg Val Wing Gln Leu He Glu 100 105 110 Gln He Gly Met Glu Gly Phe Wing Asp Arg Arg Tyr Gly Val Leu Ser 115 120 125 Gly Gly Glu Lys Arg Arg Thr Asp He Ala Arg Ala Leu Leu His Ser 130 135 140 Pro Asp He Leu Phe Leu Asp Glu Pro Thr Wing Gly Leu Asp Pro Arg 145 150 155 160 Ser Arg Arg Gln Val Trp Asp Thr He Asn Ser Leu Arg Asn Asp Val .., & tt 1? 165 170 175 Gly Leu Thr Val Phe Leu Thr Thr His Tyr Met Glu Glu Thr Glu Leu 180 185 190 Wing Asp Ser Val Leu He He Asp Arg Gly Lys Glu Val Wing Ser Gly 195 200 205 Thr Pro Met Glu Leu Arg Wing Arg Tyr Thr Thr Thr Glu Leu Thr Leu 210 215 220 Arg Thr Asn Asp Pro Thr His Ser Gly Lys Glu Leu Wing His Leu Ser 225 230 235 240 Pro Glu He Asp Gly Asp Arg Leu Arg He Lys Leu Glu Asn Gly Leu 245 250 255 Glu Wing Wing Arg Leu Wing Thr Glu Leu Asp Gly Val Leu Asp Val Glu 260 265 270 He Arg His Gly Ser Met Asp Asp Val Phe Leu Wing Val Thr Wing Glu 275 280 285 Arg Lys Arg Ser 290 < 210 > 353 < 211 > 1920 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1897) < 223 > RXA02224 < 400 > 353 gcttcgttcga < ggccggaaaa ccgtcgtcat tat: gtcgaac ccgacgtggc acggcgtcgc 60 aaagcagatg traatctgatt tttcggaagg ggtgaagtag atg gcg cag cat gag 115 Met Wing Gln His Glu 1 5 cgc gtt gcg gat gcg ctg cag ccg gcg tcg ttg gcg gag tcg tgg cgt 163 Arg Val Ala Asp Ala Leu Gln Pro Ala Ser Leu Ala Glu Ser Trp Arg 10 15 20 gag ctg aaa acg atg ect tcg ggg ccc aag gcc tgg tat gtg agt 211 Glu Leu Lys Thr Met Pro Ser Gly Pro Lys Wing Trp Trp Tyr Val Ser 25 30 35 ttc gtg gtt att age gtg gtc acg gtc gtg gcg atg gtc ggc acg tcc 259 Phe Val Val He Ser Val Val Thr Val Val Ala Met Val Gly Thr Ser 40 45 50 aac ttg ttg ggc tat tcc gtt gat ctg ate aat ggg cag tcg ttg ccg 307 Asn Leu Leu Gly Tyr Ser Val Asp Leu He Asn Gly Gln Ser Leu Pro 55 60 65 ctg ate ggt tea gga tcg acc gca atg ate tgg ttg ctt ggt ttg gtg 355 Leu He Gly Ser Gly Ser Thr Wing Met He Trp Leu Leu Gly Leu Val 70 75 80 85 ggc gct gga att tta gca gaa act gcc ggt cgc gcg ctg ctg cat ttg 403 Gly Wing Gly He Leu Wing Glu Thr Wing Gly Arg Wing Leu Leu Gln Leu 90 95 100 gtg ate aac acc ttg gca cgt cgc ctg tcg gtg gat ctg cgg aaa gct 451 Val He Asn Thr Leu Wing Arg Arg Leu Ser Val Asp Leu Arg Lys Wing 105 110 115 gcg ctg tet tcg gcg ttg cgt gca ccg gtt ect gat gtc atg gaa ttg 49 9 Ala Leu Ser Be Ala Leu Arg Ala Pro Val Pro Asp Val Met Glu Leu 120 125 130 ?, "Fc ab A # M u ^ Á-rL í f¡ ggc acg gga aac gtg att age cgc ctg acg cag gac ate gat aac act 547 Gly Thr Gly Asn Val He Ser Arg Leu Thr Gln Asp He Asp Asn Thr 135 140 145 gtg cgc ate gtc ggc atg gta ggt gtg cgt ttg gtg ate acc att ttg 595 Val Arg He Val Gly Met Val Gly Val Arg Leu Val He Thr He Leu 165 ttt 643 Phe tttttt cgg 691 Val He Leu Phe He Ala Ala He Val Val Leu He Pro Ser Gly Arg 185 190 195 aaa gcc gtg cga gct att ect tcg gca here to att gtg tcc agt acg 739 Lys Ala Val Arg Ala He Pro Ser Ala Thr Asn He Val Ser Ser Thr 200 205 210 gag gcg cgt cga aac aat ctg etc etc gat acg ate cgt ggc att gaa 787 Glu Wing Arg Arg Asn Asn Leu Leu Asp Thr He Arg Gly He Glu 215 220 225 here ctg cgt gtg etc aag etc ggt gcg tgg ggt ggtg cag cgg atg cgc 835 Arg 245 att 883 He cta 931 Phe Thr Arg Leu Leu Ala Leu Gly Ser He Wing Tyr Gly Leu Leu Leu 265 270 275 att ggc gtg gtt ttt gtg agt gcg ttt tgg gtt gcc cag gat gcg atg 979 He Gly Val Phe Gly Leu Ser Wing Phe Tr p Val Ala Gln Asp Wing Met 280 285 290 age att gga gcg gca acg gca gca gtt ttc gtg gtt gtg cgc atg gaa 1027 Be He Gly Wing Wing Thr Wing Wing Val Phe Val Val Val Arg Met Glu 15 295 300 305 att fall gtg ttc aac gtg ctg ttc ttc gca tcg gaa att cag agt gcg 1075 He His Val Phe Asn Val Leu Phe Phe Wing Ser Glu He Gln Ser Wing 310 315 320 325 tet act tet ctt ggt cgc gcg gtg tcc ctt gcc cag atg gct cgt cgc 1123 Be Thr Ser Leu Gly Arg Ala Val Ser Leu Ala Gln Met Ala Arg Arg 330 335 340 • ^ acc gaa cag ctg tet gag tet gcc gat tgc here gaa cca ccc tcc gtg 1171 Thr Glu Gln Leu Ser Glu Be Wing Asp Cys Thr Glu Pro Pro Ser Val 345 350 355 act gtg cag gac gtg acg ttt aaa tat ccc ggc ggc gtg gcc att ttg 1219 Thr Val Gln Asp Val Thr Phe Lys Tyr Pro Gly Gly Val Wing He Leu 20 360 365 370 gag gat ttc aat ctg gtc ttg gaa gca gga here ac gcg ctg gtc 1267 Glu Asp Phe Asn Leu Val Leu Glu Wing Gly Thr Thr Thr Wing Leu Val 375 380 385 ggt act tet ggt gcg gga aaa tcc acg etc gcg ggc gtc att gcg ggg 1315 Gly Thr Ser Gly Wing Gly Lys Ser Thr Leu Wing Gly Val He Wing Gly 390 395 400 405 ctg cag cgc ect gat tcc ggc gcc gtt ttg gtc ggg ggc ate aac acc 1363 Leu Gln Arg Pro Asp Ser Gly Wing Val Leu Val Gly Gly He Asn Thr 410 415 420 gcc acc gtc acc gac acg tgg act acc cgc cag gtt gcg ctg ate age 1411 Wing Thr Val Thr Asp Thr Trp Thr Thr Arg Gln Val Wing Leu He Ser 25 425 430 435 t i-t t; cag gaa gtc falls ctt ttc gca ggc act ctg gca gag gat ctt cgc atg 1459 Gln Glu Val His Leu Phe Wing Gly Thr Leu Wing Glu Asp Leu Arg Met 440 445 450 gcc aat gcg falls gcc acc gac gcg cag etc falls gca gcg etc gag tcg 1507 Wing Asn Wing His Wing Thr Asp Wing Gln Leu His Wing Wing Leu Glu Ser 455 460 465 gtc ggg etc ggg caw atg here act gct ttt cga cgt ttc ttt cca tcc 1555 Val Gly Leu Gly Gln Met Thr Thr Wing Phe Arg Arg Phe Phe Pro Ser 470 475 480 485 gga tta gac acc aaa att ggc gcc gc gca gaa gaa etc acc ect gaa 1603 Gly Leu Asp Thr Lys He Gly Wing Gly Wing Glu Glu Leu Thr Pro Glu 490 495 500 ate caa cag ca tet ctt gcc cgc ate gtg etc cgc aat cca ect 1651 He Gln Gln Gln He Ser Leu Ala Arg He Val Leu Arg Asn Pro Pro 505 510 515 gtg ttg ate atg gat gaa gcc acc agt gaa gcc ggc age gat gat gcc 1699 Val Leu He Met Asp Glu Wing Thr Ser Glu Wing Gly Ser Asp Asp Wing 520 525 530 cgc atg ttg gaa aaa gcc gcc here gaa ate gca cga aac cgc acc acc 1747 Arg Met Leu Glu Lys Ala Wing Thr Glu He Wing Arg Asn Arg Thr Thr 535 540 545 ttg gtt gtt gcg falls cgc ctt gac ca gca gtt gtc gca gat cgc ate 1795 Leu Val Val Wing His Arg Leu Asp Gln Wing Val Val Wing Asp Arg He 550 555 560 565 ate gtg atg gaa ca ggc here ate gaa gac ggc act falls cag gaa 1843 He Val Met Glu Gln Gly Thr He Thr Glu Asp Gly Thr His Gln Glu 570 575 580 tta ctt gtt ttt gag ggc cgc tac gcg cag ctg tat caa cga tgg agt 1891 Leu Leu Ala Phe Glu Gly Arg Tyr Ala Gln Leu Tyr Gln Arg Trp Ser 585 590 595 gct caà tagttcaaat ccaccacaaa etc 1920 Ala Gln < 210 > 354 < 211 > 599 < 212 > PRT < 213 > Corynebacterium glutamicum <; 400 > 354 Met Wing Gln His Glu Arg Val Wing Asp Wing Leu Gln Pro Wing Ser Leu 1 5 10 15 Wing Glu Ser Trp Arg Glu Leu Lys Thr Met Pro Ser Gly Pro Lys Wing 20 25 30 Trp Trp Tyr Val Ser Phe Val Val He Ser Val Val Thr Val Val Ala 35 40 45 Met Val Gly Thr Ser Asn Leu Leu Gly Tyr Ser Val Asp Leu He Asn 50 55 60 Gly Gln Ser Leu Pro Leu He Gly Ser Gly Ser Thr Ala Met He Trp 65 70 75 80 Leu Leu Gly Leu Val Gly Wing Gly He Leu Wing Glu Thr Wing Gly Arg 85 90 95 Wing Leu Leu Gln Leu Val He Asn Thr Leu Wing Arg Arg Leu Ser Val 100 105 110 Asp Leu Arg Lys Wing Wing Leu Being Wing Leu Arg Wing Pro Val Pro 115 120 125 Asp Val Met Glu Leu Gly Thr Gly Asn Val He Ser Arg Leu Thr Gln 130 135 140 Asp He Asp Asn Thr Val Arg He Val Gly Met Val Gly Val Arg Leu 145 150 155 160 Val He Thr He Leu He Leu Pro Ser Ser Leu Phe Ala Leu Met Thr 165 170 175 Val Leu Thr Asn Asp Thr He Arg Gly He Glu Thr Leu Arg Val Leu Lys Leu Gly Wing Trp Gly 225 230 235 240 Val Gln Arg Met Arg Gln Wing Ser Trp Thr Wing Val Gln Wing Thr Wing 245 250 255 Asp Arg Wing Pro He Phe Thr Arg Leu Leu Wing Leu Gly Ser He Ala 260 265 270 Tyr Gly Leu Leu Leu He Gly Val Phe Gly Leu Ser Ala Phe Trp Val Gln Met Wing Arg Arg Thr Glu Gln Leu Ser Glu Be Wing Asp Cys Thr 340 345 350 Glu Pro Pro Ser Val Thr Val Gln Asp Val Thr Phe Lys Tyr Pro Gly 355 360 365 Gly Val Ala He Leu Glu Asp Phe Asn Leu Val Leu Glu Wing Gly Thr 370 375 380 Thr Thr Wing Leu Val Gly Thr Ser Gly Wing Gly Lys Ser Thr Leu Wing 15 385 390 395 400 Gly Val He Wing Gly Leu Gln Arg Pro Asp Ser Gly Wing Val Leu Val 405 410 415 Gly Gly He Asn Thr Wing Thr Val Thr Asp Thr Trp Thr Thr Arg Gln 420 425 430 Val Ala Leu He Ser Gln Glu Val His Leu Phe Wing Gly Thr Leu Wing 445 Wing Gln Leu His Thr Wing Phe Arg 465 470 475 480 Arg Phe Phe Pro Ser Gly Leu Asp Thr Lys He Gly Wing Gly Wing Glu 20 485 490 495 Glu Leu Thr Pro Glu He Gln Gln Gln He Ser Leu Wing Arg He Val 500 505 510 Leu Arg Asn Pro Pro Val Leu He Met Asp Glu Wing Thr Ser Glu Wing 515 520 525 Gly Ser Asp Asp Ala Arg Met Leu Glu Lys Wing Wing Thr Glu He Wing 530 535 540 Arg Asn Arg Thr Thr Leu Val Val Wing His Arg Leu Asp Gln Wing Val 545 550 555 560 Val Wing Asp Arg He He Val Val Met Glu Gln Gly Thr He Thr Glu Asp 565 570 575 Gly Thr His Gln Glu Leu Leu Wing Phe Glu Gly Arg Tyr Wing Gln Leu 25 580 585 590 ^ m ^ ggg ^ gm j-i rt?, ít., ».J,, Tyr Gln Arg Trp Ser Ala Gln 595 < 210 > 355 < 211 > 1653 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > .CDS < 222 > (101) .. (1630) < 223 > RXN01602 < 400 > 355 tgcaggccac atgcctccca gtgccgtctc tgcacgttga ttttcccctg ccacgactgg 60 tcgcagggcg actttctagc acttttaaag gaatttttta atg gct aaa acc cat 115 Met Wing Lys Thr His 1 5 tta att 163 Leu He 20 att gtt 211 He Val ggt gag aat ggt cga ggt aaa acc here ctt ctg cga gca ctg gct cga 259 Gly Glu Asn Gly Arg Gly Lys Thr Thr Leu Leu Arg Wing Leu Wing Arg 40 45 50 gaa tcc ccg cca tet gca ggt gag att etc act cat ggc acg gta gca 307 Glu Phe Pro Pro Be Wing Gly Glu He Leu Thr His Gly Thr Val Wing 55 60 65 att gct cat caá falls atg ect ggt gat ctg tcc gtc gga gag ate 355 He Ala His Gln His Met Pro Wing Gly Asp Leu Ser Val Gly Glu He 70 75 80 85 15 tgt gat gag gca att cgt gat tea aag aat gct etc gaa gag ctt gag 403 Cys Asp Glu Wing He Arg Asp Ser Lys Asn Ala Leu Glu Glu Glu Leu Glu 90 95 100 aga gct gga gct cta ctt gag here aac act gcg cae gca ctt gat gga 451 Arg Ala Gly Ala Leu Leu Glu Thr Asn Thr Ala His Ala Leu Asp Gly 105 110 115 tat caá ca gcc ctt gat gcc gct gaa gtg ctt gac gca tgg aac gct 499 Tyr Gln Gln Wing Leu Asp Wing Wing Glu Val Leu Asp Wing Trp Asn Wing 120 125 130 gaa cat cga tta gaa aaa gct cgc age ttt ggc gcg ate acc gat 547 Glu His Arg Leu Glu Lys Wing Leu Arg Ser Phe Gly Wing He Thr Asp 135 140 145 20 aga tcc cgt gca etc agt gag cta tcg ate ggg caa agg tat cgg gta 595 Arg Ser Arg Ala Leu Ser Glu Leu Ser He Gly Gln Arg Tyr Arg Val 150 155 160 165 cgg ctg gcc tgc etc ate ggt ggc gat gct gat att ttg ctt etc gat 643 Arg Leu Wing Cys Leu He Gly Gly Asp Wing Asp He Leu Leu Leu Asp 170 175 180 gaa ccc acc aat cat ctt gac cgg ggc gcg ctt aac tat etc acc gaa 691 Glu Pro Thr Asn His Leu Asp Arg Gly Ala Leu Asn Tyr Leu Thr Glu 185 190 195 gcc ata acc tcc falls aaa ggt gtg gta ctt gtt gtt tet cat gat ca 739 Ala He Thr Ser His Lys Gly Val Val Leu Val Val Ser His Asp Gln 25 200 205 210 * - * - * - * - ^ «* gca ctg ate aaa gat gtc gcg gat ttc ate ate gat att gat tea acc 787 Wing Leu He Lys Asp Val Wing Asp Phe He He Asp He Asp Ser Thr 215 220 225 cca gac ggc cta cca cgg ate tat cat gag ggt ttt gat tet tat cga 835 Pro Asp Gly Leu Pro Arg He Tyr His Glu Gly Phe Asp Ser Tyr Arg 230 235 240 245 cgc cag agg agt gcg ctt ctt gaa act tgg agg cag gat tat gcc gct 883 Wing cgc 931 Arg 265 270 275 cag cgg gtg aat tet tcg tgg aaa ect cca aaa gga acg gga aaa falls 979 Gln Arg Val Asn Ser Ser Trp Lys Pro Pro Lys Gly Thr Gly Lys His 280 285 290 act cgc gca tet cgg gct ccc gga gtg gtg cag gcc tta aag cga gca 1027 Thr Arg Ala Ser Arg Ala Pro Gly Val Val Gln Ala Leu Lys Arg Ala 295 300 305 cag gat gcg ttg gat age aaa gcg ttg gac gtt ccc ccg gct ccg gcc 1075 Gln Asp Ala Leu Asp Ser Lys Wing Leu Asp Val Pro Pro Wing Pro Wing 10 310 315 320 325 cca ttg ctt ctg ect acc ttg aaa gtg cga cca gat aaa ccc atg gtg 1123 Pro Leu Leu Leu Pro Thu Leu Lys Val Arg Pro Asp Lys Pro Met Val 330 335 340 * gac ttt tcg gac ctt ttt gta ccc ccc ctc gtc gcc tea cgc tea 1171 Asp Phe Ser Asp Leu Phe Val Pro His Arg Leu Arg Leu Pro Gly Ser 345 350 355 cat tea gtg gta tea ggt gac aaa ata gtg ate act ggt gac aac ggc 1219 His Ser Val Val Ser Gly Asp Lys He Val He Thr Gly Asp Asn Gly 360 365 370 gct ggc aaa tea acg etc ate gaa gtc ttg tet ggg gtt ttg act ccg 1267 Wing Gly Lys Ser Thr Leu He Glu Val Leu Ser Gly Val Leu Thr Pro 15 375 380 385 gca agt ggt tcg gtt gca aac cat gcc cga act ggg gtt etc ggc ca 1315 Wing Ser Gly Ser Val Wing Asn His Wing Arg Thr Gly Val Leu Gly Gln 390 395 400 405 gaa tea ctt gtc ggc gag gtg cca tea ata gca cga gat cae gca gtt 1363 Glu Ser Leu Val Gly Glu Val Pro Ser He Wing Arg Asp His Wing Val 410 415 420 aag tgg gga ctt tta agt gtt gag gag age cga ttt gcc cta cag gaa 1411 Lys Trp Gly Leu Leu Ser Val Glu Glu Ser Arg Phe Ala Leu Gln Glu 425 430 435 ttc tea att ggt caá cgc aga aga cta gat ttg gcc atg tcg tta gct 1459 Phe Ser Gly Gln Arg Arg Arg Leu Asp Leu Wing Met Ser Leu Wing 20 440 445 450 ggc aat ect gaa ctg ttg ctt etc gat gaa ect tcg aac cat ctg tet 1507 Gly Asn Pro Glu Leu Leu Leu Leu Asp Glu Pro Ser Asn His Leu Ser 455 460 465 atg falls ttg gtt tcc gca ctt hgag tgg ctg gac acg ac gcg gct 1555 Met His Leu Val Ser Wing Leu Thr Glu Trp Leu Asp Thr Thr Wing Wing 470 475 480 485 gca gtg ate atg gta acg cat gat cga cag cta etc cgc gat acg gct 1603 Wing Val He Met Val Thr His Asp Arg Gln Leu Leu Arg Asp Thr Wing 490 495 500 cat tgg agg falls ate gag ttg aaa tet taagaatt; cg caagggcttt 1650 His Trp Arg His He Glu Leu Lys Ser 25 505 510 falls 1653 < 210 > 356 < 211 > 510 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 356 Met Ala Lys Thr His He Arg Leu Gln Asp Leu Ser Leu Ser Tyr Thr 1 5 10 15 Ser Thr Pro Leu He Thr Lys Leu Asn He Thr Val Ser Ser Gly Gln 20 25 30 Cys Ala Val He Val Gly Glu Asn Gly Arg Gly Lys Thr Thr Leu Leu 35 40 45 Arg Wing Leu Wing Arg Glu Phe Pro Pro Be Wing Gly Glu He Leu Thr 50 55 60 His Gly Thr Val Wing Wing His Gln His Met Pro Wing Gly Asp Leu 65 70 75 80 Ser Val Gly Glu He Cys Asp Glu Wing He Arg Asp Ser Lys Asn Wing 85 90 95 Leu Glu Glu Leu Glu Arg Wing Gly Wing Leu Leu Glu Thr Asn Thr Wing 10 100 105 110 His Wing Leu Asp Gly Tyr Gln Gln Wing Leu Asp Wing Wing Glu Val Leu 115 120 125 Asp Wing Trp Asn Wing Glu His Arg Leu Glu Lys Wing Leu Arg Ser Phe 130 135 140 Gly Wing He Thr Asp Arg Ser Arg Wing Leu Ser Glu Leu Ser He Gly 145 150 155 160 Gln Arg Tyr Arg Val Arg Leu Wing Cys Leu He Gly Gly Asp Wing Asp 165 170 175 He Leu Leu Leu Asp Glu Pro Thr Asn His Leu Asp Arg Gly Wing Leu 180 185 190 15 Asn Tyr Leu Thr Glu Wing He Thr Ser His Lys Gly Val Val Leu Val 195 200 20 5 Val Ser Asp Gln Ala Leu He Lys Asp Val Wing Asp Phe He He 210 215 220 Asp He Asp Ser Thr Pro Asp Gly Leu Pro Arg He Tyr His Glu Gly 225 230 235 240 ~ Phe Asp Ser Tyr Arg Arg Gln Arg Ser Wing Leu Leu Glu Thr Trp Arg "245 250 255 Gln Asp Tyr Wing Wing Wing Gln Thr Val Gln Gln Gln Leu Gln Glu Asp 260 265 270 Leu Glu His Wing Arg Gln Arg Val Asn Ser Ser Trp Lys Pro Pro Lys 275 280 285 20 Gly Thr Gly Lys His Thr Arg Wing Being Arg Wing Pro Gly Val Val Gln 290 295 300 Wing Leu Lys Arg Wing Gln Asp Wing Leu Asp Ser Lys Wing Leu Asp Val 305 310 315 320 Pro Pro Wing Pro Wing Pro Leu Leu Pro Thr Leu Lys Val Arg Pro 325 330 335 Asp Lys Pro Met Val Asp Phe Ser Asp Leu Phe Val Pro His Arg Leu 340 345 350 Arg Leu Pro Gly Ser His Val Val Ser Gly Asp Lys He Val 355 360 365 Thr Gly Asp Asn Gly Wing Gly Lys Ser Thr Leu He Glu Val Leu Ser 370 375 380 25 Gly Val Leu Thr Pro Wing Ser Gly Ser Val Wing Asn His Wing Arg Thr 385 390 395 400 Gly Val Leu Gly Gln Glu Ser Leu Val Gly Glu Val Pro Ser He Wing 405 410 415 Arg Asp His Wing Val Lys Trp Gly Leu Leu Ser Val Glu Glu Ser Arg 420 425 430 Phe Ala Leu Gln Glu Phe Ser He Gly Gln Arg Arg Arg Leu Asp Leu 435 440 445 Wing Met Ser Leu Wing Gly Asn Pro Glu Leu Leu Leu Asu Glu Pro 450 455 460 Ser Asn His Leu Ser Met His Leu Val Ser Wing Leu Thr Glu Trp Leu 465 470 475 480 Asp Thr Thr Wing Wing Wing Val He Met Val Thr His Asp Arg Gln Leu 485 490 495 Leu Arg Asp Thr Wing His Trp Arg His He Glu Leu Lys Ser 500 505 510 < 210 > 357 < 211 > 879 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (856) < 223 > RXN02515 < 400 > 357 gtggctaagc; acagttactt ggccaagctg ggcggcagaa aaatcggccc; agetaatact 60 tca < gttt; aaa; attcgcttta accctgaaag attgtgacag atg age act ctt gaa 115 Met Ser Thr Leu Glu 1 5 ate cgt aac ctg falls gca cag gtc ctg ccg tcc gat gag tcc gct gag 163 He Arg Asn Leu His Wing Gln Val Leu Pro Being Asp Glu Being Wing Glu 10 15 20 ect aag gaa ate etc aag ggc gtc aac etc acc ate aac tet ggt gag 211 Pro Lys Glu He Leu Lys Gly Val Asn Leu Thr He Asn Ser Gly Glu 25 30 35 ate fall gcc ate atg ggc ect aac ggt tcc ggc aag tcc act ctt gct 259 He His Wing He Met Gly Pro Asn Gly Ser Gly Lys Be Thr Leu Wing 40 45 50 tac acc ctt ggt gga drops cca ccc tac gag gta gc gcc gag gac gtc 307 Tyr Thr Leu Gly Gly His Pro Arg Tyr Glu Val Thr Wing Gly Glu Val 55 60 65 etc etc gac ggc gag aac ate ctg gag atg gaa gtt gat gag cgt gca 355 Leu Leu Asp Gly Glu Asn He Leu Glu Met Glu Val Asp Glu Arg Ala 70 75 80 85 cgc gct ggt etc ttc ctg gcc atg cag tat cca act gaa ate ect ggc 403 Arg Ala Gly Leu Phe Leu Ala Met Gln Tyr Pro Thr Glu He Pro Gly 90 95 100 gtt tcc gtt gct aac ttc ctg cgt tcc gca gcg acc gca ate cgc ggc 451 Val Ser Val Wing Asn Phe Leu Arg Wing Wing Thr Wing He Arg Gly 105 110 115 gag gct ect aag ctt cgc gag tgg gtt aag gaa gtc cgc acc gct cag 499 Glu Ala Pro Lys Leu Arg Glu Trp Val Lys Glu Val Arg Thr Ala Gln 120 125 130 gaa gct ctg gca att gac ect gag ttc tcc aac cgc tea gtc aac gaa 547 Glu Ala Leu Ala He Asp Pro Glu Phe Ser Asn Arg Ser Val Asn Glu 135 140 145 ggt ttc tcc ggt ggc gag aag aag cgc falls gag gtt ctg cag ctt gat 595 Gly Phe Ser Gly Gly Glu Lys Lys Arg His Glu Val Leu Gln Leu Asp 150 155 160 165 ctg ctg aag cca aag tcc gcg ate atg gat gag acc gac tcc ggc ctt 643 Leu Leu Lys Pro Lys Phe Wing He Met Asp Glu Thr Asp Ser Gly Leu 170 175 180 gac gtg gat gca ctg cgc att gtt tcc gag ggc ate aac tcc tac aag 691 Asp Val Asp Ala Leu Arg He Val Ser Glu Gly He Asn Ser Tyr Lys 185 190 195 cag gag acc gaa ggt ggc ate ttg atg ate acc fall tac aag cgc ate 739 Gln Glu Thr Glu Gly Gly He Leu Met He Thr His Tyr Lys Arg He 200 205 210 etc aac tac gtt aag ect gac ttc att falls gtt tcc gcg aat ggc cag 787 Leu Asn Tyr Val Lys Pro Asp Phe He His Val Phe Wing Asn Gly Gln 215 220 225 att gtg acc acc ggt ggc gct gct gag ctt gct gac aag etc gag gct gac 835 He Val Thr Thr Gly Gly Ala Glu Leu Wing Asp Lys Leu Glu Wing Asp 230 235 240 245 ggc tac gac cag ttc ate aag taacatgt: cc gattt: cctca at -g 879 Gly Tyr Asp Gln Phe He Lys 250 < 210 > 358 < 211 > 252 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 358 Met Ser Thr Leu Glu He Arg Asn Leu His Wing Gln Val Leu Pro Ser 1 5 10 15 Asp Glu Be Wing Glu Pro Lys Glu He Leu Lys Gly Val Asn Leu Thr 20 25 30 He Asn Ser Gly Glu He His Wing He Met Gly Pro Asn Gly Ser Gly 35 40 45 Lys Ser Thr Leu Wing Tyr Thr Leu Gly Gly His Pro Arg Tyr Glu Val 50 55 60 Thr Wing Gly Glu Val Leu Leu Asp Gly Glu Asn He Leu Glu Met Glu 65 70 75 80 Val Asp Glu Arg Ala Arg Ala Gly Leu Phe Leu Ala Met Gln Tyr Pro 85 90 95 Thr Glu He Pro Gly Val Ser Val Ala Asn Phe Leu Arg Ser Ala Ala 100 105 110 Thr Ala He Arg Gly Glu Ala Pro Lys Leu Arg Glu Trp Val Lys Glu 115 120 125 Val Arg Thr Wing Gln Glu Wing Leu Wing He Asp Pro Glu Phe Ser Asn 130 135 140 Arg Ser Val Asn Glu Gly Phe Ser Gly Gly Glu Lys Lys Arg His Glu 145 150 155 160 Val Leu Gln Leu Asp Leu Leu Lys Pro Lys Phe Wing He Met Asp Glu 165 170 175 Thr Asp Ser Gly Leu Asp Val Asp Ala Leu Arg He Val Ser Glu Gly 180 185 190 He Asn Ser Tyr Lys Gln Glu Thr Glu Gly Gly He Leu Met He Thr 195 200 205 His T yr Lys Arg He Leu Asn Tyr Val Lys Pro Asp Phe He His Val 210 215 220 - »t_m t jß ^ t É ^^ S Phe Wing Asn Gly Gln He Val Thr Thr Gly Gly Wing Glu Leu Wing Asp 225 230 235 240 Lys Leu Glu Wing Asp Gly Tyr Asp Gln Phe He Lys 245 250 < 210 > 359 < 211 > 1386 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1363) < 223 > RXN00525 < 400 > 359 ccatcgtgtt -tatt¡acteac aacedtgagí: tttgctgatga atetgategg < gtggtcacca 60 tggttgaiegg < gegeatealtt gggtctgagg tgaaacactc atg age ctt gca gaa 115 Met Ser Leu Ala Glu 1 5 tea att ctt ttg gcg etc acc age ctg aga age aac aag atg cgt gca 163 10 Ser He Leu Leu Ala Leu Thr Ser Leu Arg Ser Asn Lys Met Arg Wing 10 15 20 ttg ttg acg ctg tta gga gtc ate att ggt ate gca tea gtc ate gga 211 Leu Leu Thr Leu Leu Gly Val He He Gly He Wing Ser Val He Gly 25 30 35 att ttg acc att ggt aaa gcc ctg cag gat caa act ttg aat agt ttg 259 He Leu Thr He Gly Lys Wing Leu Gln Asp Gln Thr Leu Asn Ser Leu 40 45 50 gaa age tg ggc gcg aat gat ctg tcg gcg cag gtg gag gaa cgc ccc 307 Glu Ser Leu Gly Wing Asn Asp Leu Ser Wing Gln Val Glu Glu Arg Pro 55 60 65 gac gaa gat tcc ccc gaa ccc gat atg ttc gct ttt tet 15 ggg gct gca 355 Asp Glu Asp Ser Pro Glu Pro Asp Met Phe Wing Phe Ser Gly Wing Wing 70 75 80 85 aac tet agt ggc aat ctg att ccg gaa gaa here gtt gat acg ctg cgc 403 Asn Be Ser Gly Asn Leu He Pro Glu Glu Thr Val Asp Thr Leu Arg 90 95 100 gat cgt tcc gca ggc age ate acg gga ate age gtt ggc gga atg ggt 451 Asp Arg Phe Wing Gly Be He Thr Gly He Ser Val Gly Gly Met Gly 105 110 115 acg ca gcc gcc act etc gcc gcc gac acc gca gat ctt aaa tcc gat etc 499 Thr Gln Gly Thr Leu He Gly Asp Thr Wing Asp Leu Lys Ser Asp Leu 120 125 130 etc c gtc aac gag gat tat atg tgg atg aat ggc gtc gaa atg aac 547 20 gg Leu Gly Val Asn Glu Asp Tyr Met Trp Met Asn Gly Val Glu Met Asn 135 140 145 tac ggc cgc gcc ate acg caa gac gat gtt gcc gct cag cgc ccc gtt 595 Tyr Gly Arg Wing He Thr Gln Asp Asp Val Wing Wing Gln Arg Pro Val 150 155 160 165 gcg gtc ate gcc cca gac acc ttt aat acg ctt ttc gac gca aac ccc 643 Wing Val He Wing Pro Asp Thr Phe Asn Thr Leu Phe Asp Wing Asn Pro 170 175 180 aac etc gct ctg ggg tcc gaa gta gtt ttt gaa etc aac ggt ca gag 691 Asn Leu Ala Leu Gly Ser Glu Val Wing Phe Glu Leu Asn Gly Gln Glu 185 190 195 here ttt 25 ttg cgg gtt ate ggt gtg tat aaa gaa gcc gca gca ggt gga 739 ^ gU l ^^ i ^ Thr Phe Leu Arg Val He Gly Val Tyr Lys Glu Wing Wing Wing Gly Gly 200 205 210 ctt gtg gga age aat cca acc gtc falls acc tac acc acca tat acg gtg 787 Leu Val Gly Ser Asn Pro Thr Val His Thr Tyr Thr Pro Tyr Thr Val 215 220 225 gcc aat gac ate acc acga gaa gat gga ttg aac ac tta agt ate 835 Wing Asn Asp He Thr His Thr Glu Asp Gly Leu Asn Thr Leu Ser He 230 235 240 245 cgt gca gct cag ggc gta gac cag gat tea ctt aag ggt tea ctg caa Arg Wing Wing Gln Gly Val Asp Gln Asp Ser Leu Lys Gly Ser Leu Gln 250 255 260 Acc Tac tcc gac gcg ctg tac gcc aac aat gac tcg cae falls gtt gcc 931 Thr Tyr Phe Asp Wing Leu Tyr Wing Asn Asn Asp Ser His His Val Wing 265 270 275 atg ttg gac ttc cgt aaa cag ate gaa gag ttc aac acc att etc ggc 979 Met Leu Asp Phe Arg Lys Gln He Glu Glu Phe Asn Thr He Leu Gly 280 285 290 gca atg agt ttg ggt ate ate gcc ate ggc gga att tcc ttg ctt gtc 1027 Wing Met Ser Leu Gly Be Ser Wing He Gly Gly He Ser Leu Leu Val 295 300 305 ggt ggc ate gga gtg atg aac att atg ttg gtg tet gtc acc gag cga 1075 Gly Gly He Gly Val Met Asn He Met Leu Val Ser Val Thr Glu Arg 310 315 320 325 acc cgc gaa ate ggt gtc cga aaa gcc etc ggc gct cgt cga cgt gac 1123 Thr Arg Glu He Gly Val Arg Lys Wing Leu Gly Wing Arg Arg Arg Asp 330 335 340 att cgc ctc cat ttc gtc gtt gaa gcc atg ate att tgt ttc ate ggt 1171 He Arg Leu Gln Phe Val Val Glu Ala Met He He Cys Phe He Gly 345 350 355 ggc ate etc ggc gtg ctt ttg ggc ggc att ttg gga ttg ate atg tcc 1219 Gly He Leu Gly Val Leu Leu Gly Gly He Leu Gly Leu He Met Ser 360 365 370 age gct att ggc tac att tcc tcg cca cca ctg agt gga ate gtg ate 1267 Be Ala He Gly Tyr Be Ser Leu Pro Pro Leu Ser Gly He Val He 375 380 385 gcc ttg gta ttt tcc atg gct ate ggc ctg ttt tcc ggc tac tac ccc 1315 Ala Leu Val Phe Ser Met Ala He Gly Leu Phe Phe Gly Tyr Tyr Pro 390 395 400 405 gcc aac aag gca gca aag etc gat cca att gac gcc ttg cgt tat gag 1363 Wing Asn Lys Wing Wing Lys Leu Asp Pro He Asp Wing Leu Arg Tyr Glu 410 415 420 taaaagcctc gtttttaagg tag 1386 < 210 > 360 < 211 > 421 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 360 Met Ser Leu Ala Glu Ser He Leu Leu Ala Leu Thr Ser Leu Arg Ser 1 5 10 15 Asn Lys Met Arg Ala Leu Leu Thr Leu Leu Gly Val He He Gly He 20 25 30 Wing Ser Val He Gly He Leu Thr He Gly Lys Ala Leu Gln Asp Gln 35 40 45 Thr Leu Asn Ser Leu Glu Ser Leu Gly Ala Asn Asp Leu Ser Ala Gln 50 55 60 t & vi AiAA i ^ AJa ^ »» »^ Val Glu Glu Arg Pro Asp Glu Asp Ser Pro Glu Pro Asp Met Phe Wing 65 70 75 80 Phe Ser Gly Wing Wing Asn Being Ser Gly Asn Leu He Pro Glu Glu Thr 85 90 95 Val Asp Thr Leu Arg Asp Arg Phe Wing Gly Ser He Thr Gly He Ser 100 105 110 Val Gly Gly Met Gly Thr Gln Gly Thr Leu He Gly Asp Thr Wing Asp 115 120 125 Leu Lys Ser Asp Leu Leu Gly Val Asn Glu Asp Tyr Met Trp Met Asn 130 135 140 Gly Val Glu Met Asn Tyr Gly Arg Wing He Thr Gln Asp Asp Val Wing 145 150 155 160 Wing Gln Arg Pro Val Wing Val He Wing Pro Asp Thr Phe Asn Thr Leu 165 170 175 Phe Asp Wing Asn Pro Asn Leu Wing Leu Gly Ser Glu Val Wing Phe Glu 180 185 190 Leu Asn Gly Gln Glu Thr Phe Leu Arg Val He Gly Val Tyr Lys Glu 195 200 205 Wing Wing Wing Gly Gly Leu Val Gly Being Asn Pro Thr Val His Thr Tyr 210 215 220 Thr Pro Tyr Thr Val Wing Asn Asp He Thr His Thr Glu Asp Gly Leu 225 230 235 240 Asn Thr Leu Ser He Arg Wing Wing Gln Gly Val Asp Gln Asp Ser Leu 245 250 255 Lys Gly Ser Leu Gln Thr Tyr Phe Asp Wing Leu Tyr Wing Asn Asn Asp 260 265 270 Ser His His Val Wing Met Leu Asp Phe Arg Lys Gln He Glu Glu Phe 275 280 285 Asn Thr He Leu Gly Wing Met Ser Leu Gly He Ser Wing He Gly Gly 290 295 300 He Be Leu Leu Val Gly Gly He Gly Val Met Asn He Met Leu Val 305 310 315 320 Ser Val Thr Glu Arg Thr Arg Glu He Gly Val Arg Lys Ala Leu Gly 325 330 335 Wing Arg Arg Arg Asp He Arg Leu Gln Phe Val Val Glu Wing Met He 340 345 350 He Cys Phe He Gly Gly He Leu Gly Val Leu Leu Gly Gly He Leu 355 360 365 Gly Leu He Met Being Ser Wing He Gly Tyr He Ser Leu Pro Pro Leu 370 375 380 Ser Gly He Val He Wing Leu Val Phe Ser Met Wing He Gly Leu Phe 385 390 395 400 Phe Gly Tyr Tyr Pro Wing Asn Lys Wing Wing Lys Leu Asp Pro He Asp 405 410 415 Ala Leu Arg Tyr Glu 420 < 210 > 361 < 211 > 1815 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1792) < 223 > RXN02096 < 400 > 361 cgcttcg, acg, acctcaccca cagegatate cg, cagg, aatc tcatcgcggt ttttgatgag 60 ccgttcttgt, actcctcctc cataccgcg.a gaacatctcg atg ggt ttg gat gtc 115 Met Gly Leu Asp Val 1 5 agt gat gag cag ate gaa cae gca gcc agg ctt gcc cag gct cat gat 163 Be Asp Glu Gln He Glu His Wing Wing Arg Leu Wing Gln Wing His Asp 10 15 20 ttt ate gat cgc ctt cca aac aaa tac gag gaa gtc att ggc gaa cgc 211 Phe He Asp Arg Leu Pro Asn Lys Tyr Glu Glu Val He Gly Glu Arg 25 30 35 ggc ctg acg ctt tet ggt ggt ca cc c cac ccc ate gcc etc gca cgg 259 Gly Leu Thr Leu Be Gly Gly Gln Arg Gln Arg He Wing Leu Wing Arg 40 45 50 gct ttc ctg gcg cat ccc aaa gtg ttg gtg ctt gat gat gcc acc tet 307 Wing Phe Leu Wing His Pro Lys Val Leu Val Leu Asp Asp Wing Thr Ser 55 60 65 gcc att gat gcc tcc act gag gac cgc att ttc cag gcc ttg cgc gaa 355 Ala He Asp Ala Ser Thr Glu Asp Arg He Phe Gln Ala Leu Arg Glu 70 75 80 85 gaa ctg falls gat gtc acc att ttg ate ate gcg falls cgc falls tcc act 403 Glu Leu His Asp Val Thr He Leu He He Wing His Arg His Ser Thr 90 95 100 ttg gag etc ggc gat cgg gtt ggt ctg gtc gaa gat gga cgg gta here 451 Leu Glu Leu Gly Asp Arg Val Gly Leu Val Glu Asp Gly Arg Val Thr 105 110 115 gca ctg gga ccg ttg agt gag atg cgt gat fall gct cgt ttc tcg cat 499 Wing Leu Gly Pro Leu Ser Glu Met Arg Asp His Wing Arg Phe Ser His 120 125 130 ctg atg gct ctt gat ttc cag gat tet falls gat ccg gaa ttc acc etc 547 Leu Met Ala Leu Asp Phe Gln Asp Ser His Asp Pro Glu Phe Thr Leu 135 140 145 gac aac ggt tea cta ccc age ca ga ga ca ca ttg tgg ccg gag gtc tcc 595 Asp Asn Gly Ser Leu Pro Ser Gln Glu Gln Leu Trp Pro Glu Val Ser 150 155 160 165 here gaa aag cag tac aag att ctt gcg ect gcc ect ggt cga ggc cgt 643 Thr Glu Lys Gln Tyr Lys He Leu Wing Pro Wing Pro Gly Arg Gly Arg 170 175 180 ggc atg tcc atg cca gca acc ect gag ctg etc gcc cag att gag gcg 691 Gly Met Ser Met Pro Wing Thr Pro Glu Leu Leu Wing Gln He Glu Wing 185 190 195 ctg cca gca gca acg gaa gaa here cga gtt gat gcc ggg agg cta cgc 739 Leu Pro Wing Wing Thr Glu Glu Thr Arg Val Asp Wing Gly Arg Leu Arg 200 205 210 acc agt acc tcc ggt ttc aaa ttg etc agt tta ttc aag cag gtc cgt 787 Thr Ser Thr Ser Gly Phe Lys Leu Leu Ser Leu Phe Lys Gln Val Arg 215 220 225 tgg etc gtc gtc gcg gtc ate gcg ttg ttg ctg gtg ggc gta gcc gcc 835 Trp Leu Val Val Ala Val He Ala Leu Leu Leu Val Gly Val Ala Ala 230 235 240 245 gat cta gca ttt cca here ctg atg cgc gca gcc ate gac aac ggt gtg 883 Asp Leu Ala Phe Pro Thr Leu Met Arg Ala Ala He Asp Asn Gly Val 250 255 260 caca gca caà age acc tcc acg ttg tgg tgg ate gcc ate gca ggc age 931 Gln Ala Gln Ser Thr Ser Thr Leu Trp Trp He Wing Wing Wing Gly Ser 265 270 275 gta gta gtc ctt ctg tcc tgg gcc gcc gcc gcg ate aac acg att ate 979 Val Val Val Leu Leu Ser Trp Ala Ala Ala Ala He Asn Thr He He 280 285 290 acg gca cgc acc ggt gaa cgg ctg ctt tac ggc ttg cgt ctg cgc tea 1027 Thr Ala Arg Thr Gly Glu Arg Leu Leu Tyr Gly Leu Arg Leu Arg Ser 295 300 305 ttt gtg cat cta ttg cgc ctg tcc atg age tat ttc gaa cgc acc atg 1075 Phe Val His Leu Leu Arg Leu Ser Met Ser Tyr Phe Glu Arg Thr Met 310 315 320 325 tcc ggc cgc ate atg acg cgc atg acc acc gac ate gac aac etc tcg 1123 Be Gly Arg He Met Thr Arg Met Thr Thr Asp He Asp Asn Leu Ser 330 335 340 tcc ttc etc caa tea ggt ctg gcg caa here gtt gtc tet gtg ggc acg 1171 Be Phe Leu Gln Be Gly Leu Wing Gln Thr Val Val Ser Val Gly Thr 345 350 355 etc gtt gtg gtc gtc acc atg etc gcc ate acc gac gca caca cta gca 1219 Leu He Gly Val Val Thr Met Leu Ala He Thr Asp Ala Gln Leu Ala 360 365 370 etc gtt gcg ctg tcc gtg gtg ccg ate ate ate gtg etc act etc att 1267 Leu Val Ala Leu Ser Val Val Pro He He He Val Leu Thr Leu He 375 380 385 ttc cga cgc ate age tcc agg ctg tac acc gct tea cgc gag ca gcc 1315 Phe Arg Arg Be Being Arg Leu Tyr Thr Wing Being Arg Glu Gln Wing 390 395 400 405 age cag gtc aac gcg gta ttc falls gag tcc ate gcc ggt tta cgc acc 1363 Be Gln Val Asn Ala Val Phe His Glu Be He Wing Gly Leu Arg Thr 410 415 420 gcg cag atg fall cgc atg gaa gac ca gtc ttt gac aat tat gcg ggc 1411 Wing Gln Met His Arg Met Glu Asp Gln Val Phe Asp Asn Tyr Wing Gly 425 430 435 gaa gca gag gaa ttc cga cgc ctg cgt gtg aaa tcc cag acg gcc ate 1459 Glu Ala Glu Glu Phe Arg Arg Leu Arg Val Lys Ser Gln Thr Ala He 440 445 450 gcc ate tac tc ccc ggc ctt ggc gcg etc tet gaa ate gcc cag gca 1507 Wing He Tyr Phe Pro Gly Leu Gly Wing Leu Ser Glu He Wing Gln Wing 455 460 465 etc gtc etc ggt ttc ggc gca ctg ca gta acg cgc ggc gac ate tcc 1555 Leu Val Leu Gly Phe Gly Wing Leu Gln Val Thr Arg Gly Asp He Ser 470 475 480 485 gcg gta gta gtc gtc gtc gtg ctg gtc atc ggc gtc ctg gtc tgc gtc 1603 Thr Gly Val Leu Val Wing Phe Val Leu Tyr Met Gly Leu Met Phe Gly 490 495 500 ccc ate caa cata cta age caat ate tcc gac tcc tac caá ca gcc gcc 1651 Pro He Gln Gln Leu Ser Gln He Phe Asp Ser Tyr Gln Gln Ala Wing 505 510 515 gtc ggc ttc cgt cgc ate acc gaa ctg etc gca acg cag ccc age gtc 1699 Val Gly Phe Arg He Thr Glu Leu Leu Wing Thr Gln Pro Ser Val 520 525 530 cag ate tgg gca cca here ggc acg cta ggc agg ctg cca cgc age ctt 1747 Gln He Trp Wing Pro Thr Gly Thr Leu Gly Arg Leu Pro Arg Ser Leu 535 540 545 tat tgc ttg acg acg tea ect tcg gct att cag acg ate cga tcc 1792 Tyr Cys Leu Thr Thr Ser Pro Be Wing He Gln Thr He Arg Ser 550 555 560 tagacaac: gt caccgtccctg ate 1815 < 210 > 362 < 211 > 564 l ^ á- ^ l.-i JfcA..a ¡htoAm * * »-. ~ í- ^ .. t.Ír. r < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 362 Met Gly Leu Asp Val Ser Asp Glu Gln He Glu His Ala Ala Arg Leu 1 5 10 15 Wing Gln Wing His Asp Phe He Asp Arg Leu Pro Asn Lys Tyr Glu Glu 20 25 30 Val He Gly Glu Arg Gly Leu Thr Leu Ser Gly Gly Gln Arg Gln Arg 35 40 45 He Ala Leu Ala Arg Ala Phe Leu Ala His Pro Lys Val Leu Val Leu 50 55 60 Asp Asp Wing Thr Ser Wing He Asp Wing Ser Thr Glu Asp Arg He Phe 65 70 75 80 Gln Ala Leu Arg Glu Glu Leu His Asp Val Thr He Leu He He Wing 85 90 95 His Arg His Ser Thr Leu Glu Leu Gly Asp Arg Val Gly Leu Val Glu 100 105 110 Asp Gly Arg Val Thr Ala Leu Gly Pro Leu Ser Glu Met Arg Asp His 115 120 125 Ala Arg Phe Ser His Leu Met Ala Leu Asp Phe Gln Asp Ser His Asp 130 135 140 Pro Glu Phe Thr Leu Asp Asn Gly Ser Leu Pro Ser Gln Glu Gln Leu 145 150 155 160 Trp Pro Glu Val Ser Thr Glu Lys Gln Tyr Lys He Leu Wing Pro Wing 165 170 175 Pro Gly Arg Gly Arg Gly Met Be Pro Pro Wing Thr Pro Glu Leu Leu 180 185 190 Wing Gln He Glu Wing Leu Pro Wing Wing Thr Glu Glu Thr Arg Val Asp 195 200 205 Wing Gly Arg Leu Arg Thr Ser Thr Ser Gly Phe Lys Leu Leu Ser Leu 210 215 220 Phe Lys Gln Val Arg Trp Leu Val Val Ala Val He Ala Leu Leu Leu 225 230 235 240 Val Gly Val Ala Ala Asp Leu Ala Phe Pro Thr Leu Met Arg Ala Ala 245 250 255 He Asp Asn Gly Val Gln Ala Gln Ser Thr Ser Thr Leu Trp Trp He 260 265 270 Ala He Ala Gly Ser Val Val Val Leu Leu Ser Trp Ala Ala Ala Ala 275 280 285 He Asn Thr He He Thr Wing Arg Thr Gly Glu Arg Leu Leu Tyr Gly 290 295 300 Leu Arg Leu Arg Ser Phe Val His Leu Leu Arg Leu Ser Met Ser Tyr 305 310 315 320 Phe Glu Arg Thr Met Ser Gly Arg He Met Thr Arg Met Thr Thr Asp 325 330 335 He Asp Asn Leu Being Ser Phe Leu Gln Being Gly Leu Ala Gln Thr Val 340 345 350 Val Ser Val Gly Thr Leu He Gly Val Val Thr Met Leu Ala He Thr 355 360 365 Asp Ala Gln Leu Ala Leu Val Ala Leu Ser Val Val Pro He He He 370 375 380 Val Leu Thr Leu He Phe Arg Arg He Ser Ser Arg Leu Tyr Thr Wing 385 390 395 400 Ser Arg Glu Gln Ala Ser Gln Val Asn Ala Val Phe His Glu Ser He 405 410 415 Wing Gly Leu Arg Thr Wing Gln Met His Arg Met Glu Asp Gln Val Phe 420 425 430 Asp Asn Tyr Wing Gly Glu Wing Glu Glu Phe Arg Arg Leu Arg Val Lys 435 440 445 Ser Gln Thr Wing Wing He Tyr Phe Pro Gly Leu Gly Ala Leu Ser 450 455 460 Glu He Ala Gln Ala Leu Val Leu Gly Phe Gly Ala Leu Gln Val Thr 465 470 475 480 Arg Gly Asp He Ser Thr Gly Val Leu Val Ala Phe Val Leu Tyr Met 485 490 495 Gly Leu Met Phe Gly Pro He Gln Gln Leu Ser Gln He Phe Asp Ser 500 505 510 Tyr Gln Gln Wing Wing Val Gly Phe Arg Arg He Thr Glu Leu Leu Wing 515 520 525 Thr Gln Pro Ser Val Gln He Trp Wing Pro Thr Gly Thr Leu Gly Arg 530 535 540 Leu Pro Arg Ser Leu Tyr Cys Leu Thr Thr Ser Pro Be Ala He Gln 545 550 555 560 Thr He Arg Ser < 210 > 363 < 211 > 1203 10 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1180) < 223 > RXN00412 < 400 > 363 cttttgacga, acaccacgtc g < egtacgctit cctcggggcg ttaaactatt 1; gtcttccag 60 cttttgtt; cc < ccgacttttg tacgaatcg; a ggacaccgtc gtg tea falls acc gcg 115 15 Val Ser His Thr Wing 1 5 tcc here ccg acg cca gag gaa tac tcc gcg cag cac ccc age acc cag 163 Ser Thr Pro Thr Pro Glu Glu Tyr Ser Wing Gln Gln Pro Ser Thr Gln 10 15 20 ggc act cgc gtt gag ttc cgc ggc ata acc aaa gtc ttt age aac aat 211 Gly Thr Arg Val Glu Phe Arg Gly He Thr Lys Val Phe Ser Asn Asn 25 30 35 aaa tet gct aaa acc ac gcg ctt gat aat gtc act etc acc gta gaa 259 Lys Ser Ala Lys Thr Thr Ala Leu Asp Asn Val Thr Leu Thr Val Glu 40 45 50 ccc ggt gag gta ate ggc ate ate ggt tac tet ggc gcc ggc aag tcc 307 20 Pro Gly Glu Val He Gly He He Gly Tyr Ser Gly Wing Gly Lys Ser 55 60 65 act ctt gtc cgc etc ate aat ggc ctt gac tcc ccc acg age ggt tcg 355 Thr Leu Val Arg Leu He Asn Gly Leu Asp Ser Pro Thr Ser Gly Ser 70 75 80 85 ttg ctg etc aac ggc acc gac ate gtc gga atga ccc gag tet aag ctg 403 Leu Leu Asn Gly Thr Asp He Val Gly Met Pro Glu Ser Lys Leu 90 95 100 cgt aaa ctg cgc agt aat ate ggc atg att ttc cag cag ttc aac ctg 451 Arg Lys Leu Arg Ser Asn He Gly Met He Phe Gln Gln Phe Asn Leu 105 110 115 ttc cag tcg cgt act gcg gct gga aat gtg gag tac ccg ctg gaa gtt 499 25 Phe Gln Ser Arg Thr Wing Wing Gly Asn Val Glu Tyr Pro Leu Glu Val HiiffÉ & ájá 120 125 130 gcc aag atg gac aag gca gct cgt aaa gct cgc gtg caa gaa atg etc 547 Wing Lys Met Asp Lys Wing Wing Arg Lys Wing Arg Val Gln Glu Met Leu 135 140 145 gag ttc gtc ggc ctg ggc gac aaa ggc aaa aac tac ccc gag cag ctg 595 Glu Phe Val Gly Leu Gly Asp Lys Gly Lys Asn Tyr Pro Glu Gln Leu 150 155 160 165 tcg ggc ggc cag aag cag cgc gtc ggc att gcc cgt gca ctg gcc acc 643 Be Gly Gly Gln Lys Gln Arg Val Gly He Ala Arg Ala Leu Ala Thr 170 175 180 aat cca acg ctt ttg ctt gcc gac gaa gcc acc tcc gct ttg gac cca 691 Asn Pro Thr Leu Leu Leu Wing Asp Glu Wing Thr Ser Wing Leu Asp Pro 185 190 195 gaa acc acc cat gaa gtt ctg gag ctg ctg cgc aag gta aac cgc gaa 739 Glu Thr Thr His Glu Val Leu Glu Leu Leu Arg Lys Val Asn Arg Glu 200 205 210 ctg ggc ate acc ate gtt gtg ate acc fall gaa atg gaa gtt gtg cgt 787 Leu Gly He Thr He Val Val He Thr His Glu Met Glu Val Val Arg 215 220 225 tcc ate gca gac aag gtt gct gtg atg gaa tcc ggc aaa gtt gtg gaa 835 Ser He Wing Asp Lys Val Wing Val Met Glu Ser Gly Lys Val Val Glu 230 235 240 245 tac ggc age gtc tac gag gtg ttc tcc aat cca caa here cag gtt gct 883 Tyr Gly Ser Val Tyr Glu Val Phe Ser Asn Pro Gln Thr Gln Val Wing 250 255 260 caa aag ttc gtg gcc acc gcg ctg cgt aac ac cca gac ca gtg gaa 931 Gln Lys Phe Val Ala Thr Ala Leu. Arg Asn Thr Pro Asp Gln Val Glu 265 270 275 tcg gaa gat ctg ctt age cat gag gga cgt ctg ttc acc att gat ctg 979 Ser Glu Asp Leu Leu Ser His Glu i Gly Arg Leu Phe Thr He Asp Leu 280 285 290 act gaa acg tcc ggc ttc ttt gca gca acc gct cgt gct gcc gaa caa 1027 Thr Glu Thr Ser Gly Phe Phe Wing. Wing Thr Wing Arg Wing Wing Glu Gln 295 300 305 ggt gct ttt gtc aac ate gtt falls, ggt ggc gtg acc acc ttg caa cgc 1075 Gly Ala Phe Val Asn He Val His i Gly Gly Val Thr Thr Leu Gln Arg 310 315 320 325 caá tea ttt ggc aaa atg act gtt, cga etc acc ggc aac acc gct gcg 1123 Gln Ser Phe Gly Lys Met Thr Val. Arg Leu Thr Gly Asn Thr Wing Wing 330 335 340 att gaa gag ttc tat ca a acc ttg, acc aag acc acg acc ate aag gag 1171 He Glu Glu Phe Tyr Gln Thr Leu 'Thr Lys Thr Thr He Lys Glu 345 350 355 ate acc cga tgaacgagat gatcctcgc: ia gct 1203 He Thr Arg 360 < 210 > 364 < 211 > 360 < 212 > PRT < 213 > Cc > rynebact: erium glutamicum < 400 > 364 Val Ser His Thr Wing Ser Thr Pro Thr Pro Glu Glu Tyr Ser Wing Gln 1 5 10 15 Gln Pro Ser Thr Gln Gly Thr Arg Val Glu Phe Arg Gly He Thr Lys 20 25 30 l * ¡i ^ g¡ __ «£ * Val Phe Ser Asn Asn Lys Ser Wing Lys Thr Thr Wing Leu Asp Asn Val 35 40 45 Thr Leu Thr Val Glu Pro Gly Val Val He Gly He He Gly Tyr Ser 50 55 60 Gly Wing Gly Lys Ser Thr Leu Val Arg Leu He Asn Gly Leu Asp Ser 65 70 75 80 Pro Thr Ser Gly Ser Leu Leu Leu Asn Gly Thr Asp He Val Gly Met 85 90 95 Pro Glu Ser Lys Leu Arg Lys Leu Arg Ser Asn He Gly Met He Phe 100 105 110 Gln Gln Phe Asn Leu Phe Gln Ser Arg Thr Wing Wing Gly Asn Val Glu 115 120 125 Tyr Pro Leu Glu Val Wing Lys Met Asp Lys Wing Wing Arg Lys Wing Arg 130 135 140 Val Gln Glu Met Leu Glu Phe Val Gly Leu Gly Asp Lys Gly Lys Asn 145 150 155 160 Tyr Pro Glu Gln Leu Ser Gly Gly Gln Lys Gln Arg Val Gly He Wing 165 170 175 Arg Ala Leu Wing Thr Asn Pro Thr Leu Leu Leu Wing Asp Glu Wing Thr 180 185 190 10 Ser Wing Leu Asp Pro Glu Thr Thr His Glu Val Leu Glu Leu Leu Arg 195 200 205 Lys Val Asn Arg Glu Leu Gly He Thr He Val Val He Thr His Glu 210 215 • 220 Met Glu Val Val Arg Ser He Wings Asp Lys Val Wings l Met Glu Ser 225 230 235 240 Gly Lys Val Val Glu Tyr Gly Ser Val Tyr Glu Val Phe Ser Asn Pro 245 250 255 Gln Thr Gln Val Wing Gln Lys Phe Val Wing Thr Wing Leu Arg Asn Thr 260 265 270 Pro Asp Gln Val Glu Ser Glu Asp Leu Leu Ser His Glu Gly Arg Leu 275 280 285 15 Phe Thr He Asp Leu Thr Glu Thr Ser Gly Phe Phe Wing Wing Thr Wing 290 295 300 Arg Wing Wing Gln Gln Gly Wing Phe Val Asn He Val His Gly Gly Val 305 310 315 320 Thr Thr Leu Gln Arg Gln Ser Phe Gly Lys Met Thr Val Arg Leu Thr 325 330 335 Gly Asn Thr Wing Wing He Glu Glu Phe Tyr Gln Thr Leu Thr Lys Thr 340 345 350 • Thr Thr He Lys Glu He Thr Arg 355 360 < 210 > 365 20 < 211 > 798 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (775) < 223 > RXN00411 < 400 > 365 catttggcaa aatgactgtt cgactcaccg gcaacaccgc tgcgattgaa gagttetate 60 aaaccttgac caagaccacg accatcaagg agatcacccg atg aac gag atg ate 115 25 Met Asn Glu Met He laa .___ ia_ flfc.dEaJ. a ____ & ___, 1 5 etc gca gct gac tgg aac cgg cta gga ccc acc ttc ca aac gcc ate 163 Leu Ala Ala Asp Trp Asn Arg Leu Gly Pro Thr Phe Gln Thr Ala He 10 15 20 att gac acc ctg ttg atg gtc ate ate acc atg gtg gtg gct ggc tta 211 He Asp Thr Leu Leu Met Val He He Thr Met Val Val Wing Gly Leu 25 30 35 ctg ggt ctt gtc gtc ggc ctg ctg ctt tac acc acccgc gct ggt gga 259 Leu Gly Leu Val Val Gly Leu Leu Leu Tyr Thr Thr Arg Wing Gly Gly 40 45 50 ate ttg aag aac a g a t g tc ate tt g tg aat gtg ctg gtg aac 307 He Leu Lys Asn Lys Val He Tyr Thr He Leu Asn Val Leu Val Asn 55 60 65 ttt gtt cga ccc ate cca ttc att att ttg ate gcc gcc ate aag cca 355 Phe Val Arg Pro He Pro Phe He He Leu He Ala Wing He Lys Pro 70 75 80 85 cta acg gtc gcc gtc atg ggc acc tcc ate ggc cga gat gcc ggc ate 403 Leu Thr Val Wing Val Met Gly Thr Ser He Gly Arg Asp Wing Gly He 90 95 100 ttc gtc atg gtt gtc gca gcg att ttc tet gtg gct gga cga ate gtg gag 451 Phe Val Met Val Val Wing Ala He Phe Ser Val Ala Arg He Val Glu 10 105 110 115 caa aac ttg gtc tcc att gat ect ggt gtc ate ateg gca gct cgc tcc 499 Gln Asn Leu Val Ser He Asp Pro Gly Val He Glu Ala Wing Arg Ser • 120 125 130 atg ggt gcg tcc ccg atg cgc ate ate gcc gtg ate att cca gaa 547 Met Gly Ala Pro Pro Met Arg He He Ala Thr Val He He Pro Glu 135 140 145 gca ctt gga cca ttg gtt ctg ggt tac acc ttc ctg ttc ate gcg ate 595 Ala Leu Gly Pro Leu Val Leu Gly Tyr Thr Phe Leu Phe He Wing 150 155 160 165 gtc gat atg tcc gca atg gtc ggc tac ate ggt ggt ggt gtt ctt ggt 643 Val Asp Met Being Wing Met Val Gly Tyr He Gly Gly Gly Glu Leu Gly 15 170 175 180 gac ttc gcc att gtt tac ggc tac cgc gcc tcc gac aac gaa gtt atg 691 Asp Phe Ala He Val Tyr Gly Tyr Arg Ala Phe Asp Asn Glu Val Met 185 190 195 tac gtt gcc gtc ctg gtt ate gtc ate ate gtg cag gca gcc cag ctt 739 Tyr Val Ala Val Leu Val He Val He He Val Gln Ala Ala Gln Leu 200 205 210 ctg ggc aat tgg ctg tcc aag aag ate atg cgc cgc taaacctctt 785 • Leu Gly Asn Trp Leu Ser Lys Lys He Met Arg Arg 215 220 225 gcatagaaaa acc 798 20 < 210 > 366 < 211 > 225 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 366 Met Asn Glu Met He Leu Wing Wing Asp Trp Asn Arg Leu Gly Pro Thr 1 5 10 15 Phe Gln Thr Wing He He Asp Thr Leu Leu Met Val He He Thr Met 20 25 30 Val Val Wing Gly Leu Leu Gly Leu Val Val Gly Leu Leu Leu Tyr Thr 35 40 45 25 Thr Arg Wing Gly Gly He Leu Lys Asn Lys Val He Tyr Thr He Leu 50 55 60 Asn Val Leu Val Asn Phe Val Arg Pro He Pro Phe He He Leu He 65 70 75 80 Wing Wing He Lys Pro Leu Thr Val Wing Val Met Gly Thr Ser He Gly 85 90 95 Arg Asp Wing Gly He Phe Val Val Val Val Ala Wing He Phe Ser Val 100 105 110 Wing Arg He Val Glu Gln Asn Leu Val Ser He Asp Pro Gly Val He 115 120 125 Glu Ala Wing Arg Being Met Gly Wing Being Pro Met Arg He He Wing Thr 130 135 140 Val He He Pro Glu Wing Leu Gly Pro Leu Val Leu Gly Tyr Thr Phe 145 150 155 160 Leu Phe He Wing He Val Asp Met Ser Wing Met Val Gly Tyr He Gly 165 170 175 Gly Gly Gly Leu Gly Asp Phe Wing He Val Tyr Gly Tyr Arg Wing Phe 180 185 190 Asp Asn Glu Val Met Tyr Val Wing Val Leu Val He Val He He Val 195 200 205 Gln Wing 10 Wing Gln Leu Leu Gly Asn Trp Leu Ser Lys Lys He Met Arg 210 215 220 Arg 225 < 210 > 367 < 211 > 852 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (829) 15 < 223 > RXN02614 < 400 > 367 tcattgtata cgccaccctc ggtctgctgt ctgaagcgct gatcagaget tgggaaegtc 60 acaccttccg ctaccgaaac gcataagaaa gttgctcgcc atg act gcc here ttg 115 Met Thr Ala Thr Leu 1 5 tea etc aaa ccc gca gcc act gtc cgt gga ttg cgc aaa tea tac gga 163 • Be Leu Lys Pro Wing Wing Thr Val Arg Gly Leu Arg Lys Ser Tyr Gly 10 15 20 act aaa gaa gtc etc ca gga ate gac etc acc ate aac tgc ggc gaa 211 Thr Lys 20 Glu Val Leu Gln Gly He Asp Leu Thr He Asn Cys Gly Glu 25 30 35 gta acc gcg ctg ate gga cgc tea ggt tea gga aaa tcc acc ate ctg 259 Val Thr Ala Leu He Gly Arg Ser Gly Ser Gly Lys Ser Thr He Leu 40 45 50 cgc gtg ttg gcg ggc cta tet aaa gag cat tcc ggc tet gta gaa att 307 Arg Val Leu Wing Gly Leu Ser Lys Glu His Ser Gly Ser Val Glu He 55 60 65 tcc gga aac ccg gcc gtt gcc ttc caa gag ect cgc ctg ttg ccg tgg 355 Ser Gly Asn Pro Wing Val Wing Phe Gln Glu Pro Arg Leu Leu Pro Trp 70 75 80 85 aaa acg gtg etc gat aat gtg acc ttt ggc etc aac cgc act gat att 403 25 Lys Thr Val Leu Asp Asn Val Thr Phe Gly Leu Asn Arg Thr Asp He ^^^ HHn ^ 90 95 100 tcc tgg tea gaa gca caa gaa cgc gcc tcg gca ctg ctt gca gaa gtc 451 Ser Trp Ser Glu Ala Gln Glu Arg Ala Ser Ala Leu Leu Ala Glu Val 105 110 115 aaa ctt ccc gac tcc gac gcc gcc tgg ccc etc acg etc tcc ggc ggc 499 Lys Leu Pro Asp Ser Asp Wing Wing Trp Pro Leu Thr Leu Ser Gly Gly 120 125 130 ca gcc cag cgc gtc tcc ctt gcg cga gcg etc tcc gag cca cg gag 547 Gln Ala Gln Arg Val Ser Leu Wing Arg Wing Leu He Ser Glu Pro Glu 135 140 145 ctt ttg ctt etc gac gaa ccc ttc ggc gcc etc gat gct ctg here aga 595 Leu Leu Leu Leu Asp Glu Pro Phe Gly Ala Leu Asp Ala Leu Thr Arg 150 155 160 165 ctg here gcc caa gac ctg ctg etc aaa acc gtg aac ac cg aac ttg 643 Leu Thr Ala Gln Asp Leu Leu Leu Lys Thr Val Asn Thr Arg Asn Leu 170 175 180 gga gtt ctg ctg gtc acc cat gat gtt tcc gag gcc ate gcc ate gcc ctg gcc 691 Gly Val Leu Leu Val Thr His Asp Val Ser Glu Ala He Ala Leu Ala 185 190 195 gac falls gtc ctt ctt ctc gac gac gcc gcc ccc here falls agt ttg act 739 Asp His Val Leu Leu Leu Asp Asp Gly Wing He Thr His Ser Leu Thr 200 205 210 gta gat ate ccc ggc gat cgc cgc acc fall ccc tcc ttt gcc tcc tac 787 Val Asp He Pro Gly Asp Arg Arg Thr His Pro Ser Phe Ala Ser Tyr 215 220 225 acc gct caa etc ctt gag tgg etc gaa ate acc ect gcc 829 Thr Wing Gln Leu Leu Glu Trp Leu Glu He Thr Thr Pro Wing 230 235 240 tagaaagaaa tcatgaaatt taa 852 < 210 > 368 < 211 > 243 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 368 Met Thr Ala Thr Leu Ser Leu Lys Pro Ala Ala Thr Val Arg Gly Leu 1 5 10 15 Arg Lys Ser Tyr Gly Thr Lys Glu Val Leu Gln Gly He Asp Leu Thr 20 25 30 He Asn Cys Gly Glu Val Thr Wing Leu He Gly Arg Ser Gly Ser Gly 35 40 45 Lys Ser Thr He Leu Arg Val Leu Ala Gly Leu Ser Lys Glu His Ser 50 55 60 Gly Ser Val Glu He Ser Gly Asn Pro Ala Val Ala Phe Gln Glu Pro 65 70 75 80 Arg Leu Leu Pro Trp Lys Thr Val Leu Asp Asn Val Thr Phe Gly Leu 85 90 95 Asn Arg Thr Asp He Ser Trp Ser Glu Ala Gln Glu Arg Ala Ser Ala 100 105 110 Leu Leu Ala Glu Val Lys Leu Pro Asp Ser Asp Wing Wing Trp Pro Leu 115 120 125 Thr Leu Ser Gly Gly Gln Wing Gln Arg Val Ser Leu Wing Arg Ala Leu 130 135 140 He Ser Glu Pro Glu Leu Leu Leu Leu Asp Glu Pro Phe Gly Ala Leu 145 150 155 160 Asp Ala Leu Thr Arg Leu Thr Ala Gln Asp Leu Leu Leu Lys Thr Val 165 170 175 Asn Thr Arg Asn Leu Gly Val Leu Leu Val Thr His Asp Val Ser Glu 180 185 190 Wing He Wing Wing Leu Wing Asp His Val Leu Leu Asp Asp Gly Wing He 195 200 205 Thr His Ser Leu Thr Val Asp He Pro Gly Asp Arg Arg Thr His Pro 210 215 220 Ser Phe Ala Ser Tyr Thr Ala Gln Leu Leu Glu Trp Leu Glu He Thr 225 230 235 240 Thr Pro Ala < 210 > 369 < 211 > 1080 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1057) < 223 > RXN02613 < 400 > 369 agatatcccc < ggcgatcgcc gcacccaccc ctcctttgcc tcctacaccg < rtcaactcct 60 tga < gtggtütc < gaaatcacca cacctgcct; a gaaaga; aatc atg aaa ttt aag aaa 115 Met Lys Phe Lys Lys 1 5 ate gcc etc gtt etc gcc ttc ggt cta ggc ctt gca tcc tgc tea tea 163 He Ala Ala Leu Val Leu Ala Phe Gly Leu Gly Leu Ala Ser Cys Be Ser 10 15 20 gct tet ggc gat ccc gcc acc aac gcc gat gga tcc ate gat ctg age 211 Wing Ser Gly Asp Pro Wing Thr Asn Wing Asp Gly Ser He Asp Leu Ser 25 30 35 aaa gta acc ctt aac ate ggt gat ca g ate gcc gga here gaa ca gtg 259 Lys Val Thr Leu Asn He Gly Asp Gln He Wing Gly Thr Glu Gln Val 40 45 50 etc cacta gct tea ggg gag cta gat gat gtc ect tat aaa ate gaa tgg 307 Leu Gln Ala Ser Gly Glu Leu Asp Asp Val Pro Tyr Lys He Glu Trp 55 60 65 tea tea ttt acc tet gga cca ccc ca ate ate gaa gca tta aac gca ggt 355 Being Ser Phe Thr Ser Gly Pro Pro Gln He Glu Ala Leu Asn Ala Gly 70 75 80 85 ca gt gt gt gt gt gt gt gtc gtc gtc gtc gtc gtc gtc gtc gtc gtc Gln He Asp Phe Wing He Thr Gly Asn Thr Pro Pro He He Gly Gly 90 95 100 ccc acc aac ac aaa gtg gtc tcc gcc tac aac aac g gt gt gt 456 Pro Thr Asn Thr Lys Val Val Ser Wing Tyr Asn Asn Asp Ala Leu Gly 105 110 115 gat gtc ate ttg gtc gcc ccg gat tet tea ata acc tcg gtg gct gac 499 Asp Val He Leu Val Wing Pro Asp Being Ser He Thr Ser Val Wing Asp 120 125 130 ctt gct agag aaa gtg gct gcc gcc cgc gga gcc tcc age gga gga 547 Leu Wing Gly Lys Lys Val Wing Val Wing Arg Gly Being Ser Wing His Gly 135 140 145 falls etc ate caá cata cta gaa aaa gca ggc gtg age gtt gac gac gta 595 His Leu He Gln Gln Leu Glu Lys Wing Gly Val Ser Val Asp Asp Val 150 155 160 165 gaa ate aac etc etc cac ccc tcc gac gcc aaa gcc gct ttc caa aac 643 I ^ .. ^ A & amp; amp; amp; amp; amp; amp; amp; amp; amp; amp; amp; amp; - ..i i.

Glu He Asn Leu Leu Gln Pro Ser Asp Wing Lys Wing Wing Phe Gln Asn 170 175 180 ggc cag gta gat gcg tgg gca gtg tgg gat ccc tac age tea cag gcg 691 Gly Gln Val Asp Wing Trp Wing Val Trp Asp Pro Tyr Being Gln Wing 185 190 195 gaa ctg gaa gga gct ca gtt ttg gtc agg gga gcg gga ctg gtc agt 739 Glu Leu Glu Gly Wing Gln Val Leu Val Arg Gly Wing Gly Leu Val Ser 200 205 210 ggg cat gga ttt ggt gtc gca agt gat gaa gcg etc gat gac ccc gca 787 Gly His Gly Phe Gly Val Wing Asp Glu Wing Leu Asp Asp Pro Wing 215 220 225 aag gaa gcc gcc ttg gca gat ttc etc gat cgc gtg gcc gac tet tat 835 Lys Glu Ala Ala Leu Ala Asp Phe Leu Asp Arg Val Wing Asp Ser Tyr 230 235 240 245 gaa tgg gct gaa gac aac acc gat gat gag tgg gcg acg att ttc age cha 883 Glu Trp Wing Glu Asp Asn Thr Asp Glu Trp Wing Thr He Phe Ser Gln 250 255 260 gaa tcc ggc ttt gat ccg gag gcc tet caa ctg aac acc cgc age ctg 931 Glu Ser Gly Phe Asp Pro Glu Wing Being Gln Leu Asn Thr Arg Ser Leu 265 270 275 cgc cat cag gtg ccg etc gac gag tcc gtc aac acc tat cag aac gcg 979 10 Arg His Gln Val Pro Leu Asp Glu Ser Val Asn Thr Tyr Gln Asn Wing 280 285 290 • ctt ate gac gct ttc gtc tcc gcg ggt etc gtt gag gac ttt aat ttc 1027 Leu He Asp Ala Phe Val Ser Ala Gly Leu Val Glu Asp Phe Asn Phe 295 300 305 gag gac acc gta gac acc cga ttt gag ggc taagtatgtc tgagtatggc 1077 Glu Asp Thr Val Asp Thr Arg Phe Glu Gly 310 315 aaa 1080 < 210 > 370 15 < 211 > 319 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 370 Met Lys Phe Lys Lys He Wing Leu Val Leu Wing Phe Gly Leu Gly Leu 1 5 10 15 Wing Ser Cys Ser Wing Ser Gly Asp Pro Wing Thr Asn Wing Asp Gly 20 25 30 Ser He Asp Leu Ser Lys Val Thr Leu Asn He Gly Asp Gln He Wing 35 40 45 Gly Thr Glu Gln Val Leu Gln Wing Ser Gly Glu Leu Asp Asp Val Pro 20 50 55 60 Tyr Lys He Glu Trp Ser Ser Phe Thr Ser Gly Pro Pro Gln He Glu 65 70 75 80 Wing Leu Asn Wing Gly Gln He Asp Phe Wing He Thr Gly Asn Thr Pro 85 90 95 Pro He He Gly Gly Pro Thr Asn Thr Lys Val Val Ser Wing Tyr Asn 100 105 110 Asn Asp Ala Leu Gly Asp Val He Leu Val Ala Pro Asp Be Ser He 115 120 125 Thr Ser Val Wing Asp Leu Wing Gly Lys Lys Val Wing Val Wing Arg Gly 130 135 140 Ser Ser Wing His Gly His Leu He Gln Gln Leu Glu Lys Wing Gly Val 145 150 155 160 25 itilHÍHWMMLMÉÍll¡i, »i¡ > tji ti. *., < fei ._ Ser Val Asp Asp Val Glu He Asn Leu Leu Gln Pro Ser Asp Wing Lys 165 170 175 Wing Wing Phe Gln Asn Gly Gln Val Asp Wing Trp Wing Val Trp Asp Pro 180 185 190 Tyr Ser Ser Gln Wing Glu Leu Glu Gly Ala Gln Val Leu Val Arg Gly 195 200 205 Wing Gly Leu Val Ser Gly His Gly Phe Gly Val Wing As As Glu Wing 210 215 220 Leu Asp Asp Pro Wing Lys Glu Wing Wing Leu Wing Asp Phe Leu Asp Arg 225 230 235 240 Val Wing Asp Ser Tyr Glu Trp Wing Glu Asp Asn Thr Asp Glu Trp Wing 245 250 255 Thr He Phe Ser Gln Glu Ser Gly Phe Asp Pro Glu Wing Ser Gln Leu 260 265 270 Asn Thr Arg Ser Leu Arg His Gln Val Pro Leu Asp Glu Ser Val Asn 275 280 285 Thr Tyr Gln Asn Wing Leu He Asp Wing Phe Val Wing Being Wing Gly Leu Val 290 295 300 Glu Asp Phe Asn Phe Glu Asp Thr Val Asp Thr Arg Phe Glu Gly 305 310 315 < 210 > 371 < 211 > 1698 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1675) < 223 > RXN00368 < 400 > 371 ttcttccaaa; acgcaatgaa ctagttttcc taltgcatgtta tct < ? Cttí: aa; atactgtcgac 60 gca < gcgdttt 1cacatctctg cgttgacgtc tttgtctttc atg cgt ctg ggt gtg 115 Met Arg Leu Gly Val 1 5 tgg ctg att gtc gcg ggg ttg ttt ate act ccg ttg gcg gtg gtg 163 Trp Leu He Val Wing Gly Leu Phe He Thr Pro Leu Wing Leu Val Val 15 15 ggc ttg gcg ttg gga ggc aat cag ttt ect gct ctg tgg gat tcc gga 211 Gly Leu Ala Leu Gly Gly Asn Gln Phe Pro Wing Leu Trp Asp Ser Gly 25 30 35 ttg ggc aaa gcc cta tgg aat tcc gcc tat here gtg ctt tet gcg 259 Leu Gly Lys Ala Leu Trp Asn Ser Wing Tyr Thr Thr Val Leu Ser Wing 40 45 50 gtg ggc gcg acc att ate ggc acg ate atg gct etc acg ctg gac cga 307 Val Gly Ala Thr He He Gly Thr He Met Ala Leu Thr Leu Asp Arg 55 60 65 act gat gtt ttc ggg cgc acc gcg ttg cgg tta ttt ttg tta tc ccg 355 Thr Asp Val Phe Gly Arg Thr Ala Leu Arg Leu Phe Leu Leu Ser Pro 70 75 80 85 ctg ttg ate ect ccg ttt att ggg gct att gcg tgg ttg cag ctg ttc 403 Leu Leu Pro Pro Phe He Gly Ala He Wing Trp Leu Gln Leu Phe 90 95 100 ggg aag aac cag ggc ate aac cgg ttt ttc ggc acg gaa gtg tgg gat 451 Gly Lys Asn Gln Gly He Asn Arg Phe Phe Gly Thr Glu Val Trp Asp 105 110 115 att tac ggc gct gat ggt gtg here ttt ttg ttg att gtg drops tcc tat 499 He Tyr Gly Wing Asp Gly Val Thr Phe Leu Leu He Val His Ser Tyr 120 125 130 ccc act gtg tac ate att gtt tcg gca gct ctg agg caa ctt ect agt 547 Pro Thr Val Tyr He He Val Val Wing Ala Wing Leu Arg Gln Leu Pro Ser 135 140 145 gat ttg gag ca gct gca cgg ate gcg ggg gcg gat act ttt acg gtg 595 Asp Leu Glu Gln Wing Wing Arg He Wing Gly Wing Asp Thr Phe Thr Val 150 155 160 165 ttg cgc acc ate here etc cca ctg etc aaa ect gca ttg ttg tcg gcg 643 Leu Arg Thr He Thr Leu Pro Leu Leu Lys Pro Wing Leu Leu Ser Wing 170 175 180 ttt act ctt acc here gtg gcg aac etc gcc gac ttt ggc att cca gct 691 Phe Thr Leu Thr Thr Val Wing Asn Leu Wing Asp Phe Gly He Pro Wing 185 190 195 ctg ttg gga tcg cca gcg cgt ttt gaa acc tta gcc acc atg att tat 739 Leu Leu Gly Ser Pro Wing Arg Phe Glu Thr Leu Wing Thr Met He Tyr 200 205 210 cgc ttc atg gaa tcc ggc acc gtg age aat cca ttg cag gtg gta tcc 787 Arg Phe Met Glu Ser Gly Thr Val Ser Asn Pro Leu Gln Val Val Ser 215 220 225 acc att ggc ate gtg ttg ttg ttc ctg gga ate gca gca gta acc gcg 835 Thr He Gly He Val Leu Leu Phe Leu Gly He Ala Wing Val Thr Wing 230 235 240 245 gat tat ctg gtg tet ttg tac gcg gca tea aag ttg caa gac gca gga 883 Asp Tyr Leu Val Ser Leu Tyr Wing Wing Ser Lys Leu Gln Asp Wing Gly 250 255 260 here ccg cat cgc ttt act etc aac aaa tea cga ate cca gtc age gtg 931 Thr Pro His Arg Phe Thr Leu Asn Lys Ser Arg He Pro Val Ser Val 265 270 275 ate acg tgg ate ate gcg ttg ate ate acc gcc gcc ccg ctg ctg ggt 979 He Thr Trp He He Ala Leu He He Thr Ala Ala Pro Leu Leu Gly 280 285 290 ctg gca tac aga gca tta ctg ect gcc cca ggt gtg ccg ttc aac cta 1027 Leu Ala Tyr Arg Ala Leu Leu Pro Ala Pro Gly Val Pro Phe Asn Leu 295 300 305 gac aac ate acg etc aac aac ttt gaa gca gca ctg age aat cca cga cga 1075 Asp Asn He Thr Leu Asn Asn Phe Glu Ala Wing Leu Ser Asn Pro Arg 310 315 320 325 gta ate gaa gga ttc age aac tcc etc atg tta tcc ctg ggt gca gcc 1123 Val He Glu Gly Phe Ser Asn Ser Leu Met Leu Ser Leu Gly Wing Ala 330 335 340 cta ate tgt ggg gtg ctg gga tgg ctg ate gga gtg etc ate acc cga 1171 Leu He Cys Gly Val Leu Gly Trp Leu He Gly Val Leu He Thr Arg 345 350 355 acc cag cat ttc gcc aac gta ccg ttg here etc act gtg ctg ctt ccc 1219 Thr Gln His Phe Wing Asn Val Pro Leu Thr Leu Thr Val Leu Leu Pro 360 365 370 acc gca ctg ccg ggc atg ate ate ggc gtc ggc tgg etc att ttg ggc 1267 Thr Ala Leu Pro Gly Met He He Gly Val Gly Trp Leu He Leu Gly 375 380 385 aga tac acc gga att tac aac ect tgg gtg att ttg ggt gca tat 1315 Arg Tyr Thr Gly He Tyr Asn Thr Pro Trp Val He Leu Gly Wing Tyr 390 395 400 405 gtg tgt gct ttt gcg ctg gtc gtc ca gctc gct cgc cgc gca cca etc 1363 Val Cys Ala Phe Thr Ala Leu Val Val Gln Ala Val Arg Gly Pro Leu 410 415 420 : -.í "j, rí.? ? i ^^^^ agt caa gca ccc gaa gca ate gaa gaa gcc gca cga age ggc gca gca gc 1411 Ser Gln Wing Pro Glu Wing He Glu Glu Wing Wing Arg He Ser Gly Wing 425 430 435 ggc aga tta cga tcc ate atg gac acc acc gga gcg atg gca att ccc 1459 Gly Arg Leu Arg Ser He Met Asp Thr Thr Gly Wing Met Wing Pro 440 445 450 gca gct gtc tcc gc gcg gtg gtg gtt gcg gtact act gtt gga cga gag 1507 Wing Wing Wing Wing Gly Wing Val Val Val Val Ala Val Thr Ala Val Val Arg Glu 455 460 465 tta acc gtg tcc att ttg tcg gtc ccg ggc ccg acc ac acc ctg ggt 1555 Leu Thr Val Ser He Leu Leu He Wing Pro Gly Thr Thr Thu Leu Gly 470 475 480 485 gtg cag gtg ttc aat ttg cag gcg gga aat tac aat cag gca tcg 1603 Val Gln Val Phe Asn Leu Gln Gln Wing Gly Asn Tyr Asn Gln Wing Be 490 495 500 gcg ttg tcg ttg atg ttt gcg att ate ggt ate gtg gcg etc gcg ttg 1651 Wing Leu Being Leu Met Phe Wing He He Gly He Val Wing Leu Wing Leu 505 510 515 acg gtg cgc age cag aag gag ttt taggtgtcat cgatcaaatt gcg 1698 Thr Val Arg Ser Gln Lys Glu Phe 520 525 < 210 > 372 < 211 > 525 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 372 Met Arg Leu Gly Val Trp Leu He Val Ala Gly Leu Phe He Thr Pro 1 5 10 15 Leu Ala Leu Val Val Gly Leu Ala Leu Gly Gly Asn Gln Phe Pro Wing 20 25 30 Leu Trp Asp Ser Gly Leu Gly Lys Wing Leu Trp Asn Ser Wing Tyr Thr 35 40 45 Thr Val Leu Ser Wing Val Gly Wing Thr He He Gly Thr He Met Wing 50 55 60 Leu Thr Leu Asp Arg Thr Asp Val Phe Gly Arg Thr Ala Leu Arg Leu 65 70 75 80 Phe Leu Leu Ser Pro Leu Leu Pro Pro Phe He Gly Wing He Wing 85 90 95 Trp Leu Gln Leu Phe Gly Lys Asn Gln Gly He Asn Arg Phe Phe Gly 100 105 110 Thr Glu Val Trp Asp He Tyr Gly Wing Asp Gly Val Thr Phe Leu Leu 115 120 125 He Val His Ser Tyr Pro Thr Val Tyr He He Val Ser Ala Ala Leu 130 135 140 Arg Gln Leu Pro Being Asp Leu Glu Gln Wing Wing Arg He Wing Gly Wing 145 150 155 160 Asp Thr Phe Thr Val Leu Arg Thr He Thr Leu Pro Leu Leu Lys Pro 165 170 175 Wing Leu Leu Being Wing Phe Thr Leu Thr Thr Val Wing Asn Leu Wing Asp 180 185 190 Phe Gly He Pro Wing Leu Leu Gly Ser Pro Wing Arg Phe Glu Thr Leu 195 200 205 Wing Thr Met He Tyr Arg Phe Met Glu Ser Gly Thr Val Ser Asn Pro 210 215 220 Leu Gln V al Val Ser Thr He Gly He Val Leu Leu Phe Leu Gly He ji. íri.rk ¿-ri? lMr 225 230 235 240 Ala Ala Val Thr Ala Asp Tyr Leu Val Ser Leu Tyr Ala Ala Ser Lys 245 250 255 Leu Gln Asp Ala Gly Thr Pro His Arg Phe Thr Leu Asn Lys Ser Arg 260 265 270 He Pro Val Ser Val He Thr Trp He He Ala Ala He He Thr Wing 275 280 285 Wing Pro Leu Leu Gly Leu Wing Tyr Arg Wing Leu Leu Pro Wing Pro 290 295 300 Val Pro Phe Asn Leu Asp Asn He Thr Leu Asn Asn Phe Glu Wing Wing 305 310 315 320 Leu Ser Asn Pro Arg Val He Glu Gly Phe Ser Asn Ser Leu Met Leu 325 330 335 Ser Leu Gly Ala Ala Leu He Cys Gly Val Leu Gly Trp Leu He Gly 340 345 350 Val Leu He Thr Arg Thr Gln His Phe Wing Asn Val Pro Leu Thr Leu 355 360 365 Thr Val Leu Leu Pro Thr Ala Leu Pro Gly Met He He Gly Val Gly 370 375 380 Trp Leu He Leu Gly Arg Tyr Thr Gly He Tyr Asn Thr Pro Trp Val 385 390 395 400 He Leu Gly Ala Tyr Val Cys Ala Phe Thr Ala Leu Val Val Gln Ala 405 410 415 Val Arg Gly Pro Leu Ser Gln Ala Pro Glu Ala He Glu Glu Ala Ala 420 425 430 Arg He Ser Gly Ala Gly Arg Leu Arg Ser He Met Asp Thr Thr Gly 435 440 445 Ala Ala Ala He Pro Ala Ala Phe Ala Gly Ala Val Leu Val Ala Val 450 455 460 Thr Ala Val Arg Glu Leu Thr Val Ser He Leu Leu He Ala Pro Gly 465 470 475 480 Thr Thr Thr Leu Gly Val Gln Val Phe Asn Leu Gln Gln Wing Gly Asn 485 490 495 Tyr Asn Gln Wing Being Wing Leu Being Leu Met Phe Wing He He Gly He 500 505 510 Val Wing Leu Wing Leu Thr Val Arg Being Gln Lys Glu Phe 515 520 525 < 210 > 373 < 211 > 602 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (579) < 223 > FRXA00368 < 400 > 373 tcc etc atg tta tcc ctg ggt gca gcc cta ate tgt ggg gtg ctg gga 48 Ser Leu Met Leu Ser Leu Gly Ala Ala Leu He Cys Gly Val Leu Gly 1 5 10 15 tgg ctg gga gtg gtg gtg ct ct cct cct acc gca ctg ccg ggc atg ate 144 Pro Leu Thr Leu Thr Val Leu Leu Pro Thr Ala Leu Pro Gly Met He 35 40 45 ate ggc gtc ggc tgg etc att ttg ggc aga tac acc gga att tac aac 192 He Gly Val Gly Trp Leu He Leu Gly Arg Tyr Thr Gly He Tyr Asn 50 55 60 here ect tgg gtg att ttg ggt gca tat gtg tgt gct ttt acc gcg ctg 240 Thr Pro Trp Val He Leu Gly Wing Tyr Val Cys Wing Phe Thr Ala Leu 65 70 75 80 gtt gtc ca gct gta cgc gga cca etc agt caa gca ccc gaa gca ate 288 Val Val Gln Ala Val Arg Gly Pro Leu Ser Gln Ala Pro Glu Ala He 85 90 95 gaa gaa gcc gca cga ate age ggc gca gca aga tta cga tcc tet ate atg 336 Glu Glu Wing Wing Arg He Ser Gly Wing Gly Arg Leu Arg Ser He Met 100 105 110 gac acc acc gga gcg atg gca att ccc gca gct tcc gcc gc gc gtg 384 Asp Thr Thr Gly Wing Ala Wing He Pro Wing Wing Phe Wing Wing Wing Val 115 120 125 ctg gtt gcg gta act gcg gtt cga gag tta acc gtg tcc att ttg etc 432 Leu Val Wing Val Thr Wing Val Arg Glu Leu Thr Val Ser He Leu Leu 130 135 140 ate gcg ccg ggc acc acc action ctg ggt gtg cag gtg ttc aat ttg cag 480 He Wing Pro Gly Thr Thr Thr Leu Gly Val Gln Val Phe Asn Leu Gln 145 150 155 160 cag gcg gga aat tac aat cag gca tcg gcg ttg tcg ttg atg ttt gcg 528 Gln Ala Gly Asn Tyr Asn Gln Ala Be Ala Leu Ser Leu Met Phe Wing 165 170 175 att ate ggt ate gtg gcg etc gcg ttg acg gtg cgc age cag aag gag 576 He He Gly He Val Ala Leu Ala Leu Thr Val Arg Be Gln Lys Glu 180 185 190 ttt taggtgtcat cgatcaaatt gcg 602 Phe < 210 > 374 < 211 > 193 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 374 Ser Leu Met Leu Ser Leu Gly Ala Ala Leu He Cys Gly Val Leu Gly 1 5 10 15 Trp Leu He Gly Val Leu He Thr Arg Thr Gln His Phe Wing Asn Val 20 25 30 Pro Leu Thr Leu Thr Val Leu Leu Pro Thr Ala Leu Pro Gly Met He 35 40 45 He Gly Val Gly Trp Leu He Leu Gly Arg Tyr Thr Gly He Tyr Asn 50 55 60 Thr Pro Trp Val He Leu Gly Wing Tyr Val Cys Wing Phe Thr Ala Leu 65 70 75 80 Val Val Gln Ala Val Arg Gly Pro Leu Ser Gln Wing Pro Glu Wing He 85 90 95 Glu Glu Wing Wing Arg He Ser Gly Wing Gly Arg Leu Arg Ser He Met 100 105 110 Asp Thr Thr Gly Ala Wing Wing Pro Wing Wing Phe Wing Gly Wing Val 115 120 125 Leu Val Wing Val Thr Wing Val Arg Glu Leu Thr Val Ser He Leu Leu 130 135 140 He Wing Pro Gly Thr Thr Thu Leu Gly Val Gln Val Phe Asn Leu Gln tliU, iJ. «* .- JLAlá * __ t. £ ^^ ¡¡¡¡^ * j ^^ £? ¿A ^^ 145 150 155 160 Gln Ala Gly Asn Tyr Asn Gln Wing Being Wing Leu Being Leu Met Phe Wing 165 170 175 He He Gly He Val Wing Leu Wing Leu Thr Val Arg Being Gln Lys Glu 180 185 190 Phe < 210 > 375 < 211 > 798 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (798;) < 223 > FRXA00370 < 400 > 375 ggc aaa gcc cta tgg aat tcc gcc tat here gtg ctt tet gcg gtg Gly Lys Ala Leu Trp Asn Ser Ala Tyr Thr Thr Val Leu Ser Ala Ala 1 5 10 15 ggc gcg acc att ate ggc acg ate atg gct etc acg ctg gac cga act 96 Gly Ala Thr He He Gly Thr He Met Ala Leu Thr Leu Asp Arg Thr 20 25 30 gat gtt ttc ggg cgc acc gcg ttg cgg tta ttt ttg tta tcc ccg ctg 144 Asp Val Phe Gly Arg Thr Ala Leu Arg Leu Phe Leu Leu Ser Pro Leu 35 40 45 ttg ate ect ccg ttt att ggg gct att gcg tgg ttg cag ctg ttc ggg 192 Leu He Pro Pro Phe He Gly Wing He Wing Trp Leu Gln Leu Phe Gly 50 55 60 aag aac cag ggc ate aac cgg ttt tcc ggc acg gaa gtg tgg gat att 240 Lys Asn Gln Gly He Asn Arg Phe Phe Gly Thr Glu Val Trp Asp He 65 70 75 80 tac ggc gct gat ggt gtg here ttt ttg ttg att gtg falls tcc tat ccc 288 Tyr Gly Wing Asp Gly Val Thr Phe Leu Leu He Val His Ser Tyr Pro 85 90 95 act gtg tac ate att gtt tcg gca gct ctg agg caa ctt ect agt gat 336 Thr Val Tyr He He Val Ser Wing Wing Leu Arg Gln Leu Pro Ser Asp 100 105 110 ttg gag ca gct gca cgg ate gcg ggg gcg gat act ttt acg gtg ttg 384 Leu Glu Gln Wing Wing Arg He Wing Gly Wing Asp Thr Phe Thr Val Leu 115 120 125 cgc acc ate here etc cca ctg etc aaa ect gca ttg ttg tcg gcg ttt 432 Arg Thr He Thr Leu Pro Leu Leu Lys Pro Wing Leu Leu Ser Wing Phe 130 135 140 act ctt ac gtg gcg aac etc gcc gac ttt ggc att cca gct ctg 480 Thr Leu Thr Thr Val Wing Asn Leu Wing Asp Phe Gly He Pro Wing Leu 145 150 155 160 ttg gga tcg cca gcg cgt ttt gaa acc tta gcc acc atg att tat cgc 528 Leu Gly Ser Pro Wing Arg Phe Glu Thr Leu Wing Thr Met He Tyr Arg 165 170 175 ttc atg gaa tcc ggc acc gtg age aat cca ttg cag gtg gta tcc acc 576 Phe Met Glu Ser Gly Thr Val Ser Asn Pro Leu Gln Val Val Ser Thr 180 185 190 att ggc ate gtg ttg ttg ttc ctg gga ate gca gca gta acc gcg gat 624 He Gly He Val Leu Leu Phe Leu Gly He Ala Ala Val Thr Ala Asp 195 200 205 tat ctg gtg tet ttg tac gcg gca tea aag ttg caa gac gca gga here 672 Tyr Leu Val Ser Leu Tyr Ala Ala Ser Lys Leu Gln Asp Ala Gly Thr 210 215 220 ccg cat cgc ttt act etc aac aaa tea cga ate cca gtc age gtg ate 720 Pro His Arg Phe Thr Leu Asn Lys Ser Arg He Pro Val Ser Val He 225 230 235 240 acg tgg ate ate gcg ttg ate ate acc gcc gcc ccg ctg ctg ggt ctg 768 Thr Trp He He Wing Leu He He Thr Wing Wing Pro Leu Leu Gly Leu 245 250 255 gca tac aga gca tta ctg ect gcc cca ggt 798 Wing Tyr Arg Wing Leu Leu Pro Wing Pro Gly 260 265 < 210 > '376 < 211 > 266 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 376 Gly Lys Ala Leu Trp Asn Ser Wing Tyr Thr Thr Val Leu Ser Wing Val 1 5 10 15 Gly Wing Thr He He Gly Thr He Met Wing Ala Leu Thr Leu Asp Arg Thr 20 25 30 Asp Val Phe Gly Arg Thr Ala Leu Arg Leu Phe Leu Leu Ser Pro Leu 35 40 45 Leu He Pro Pro Phe He Gly Ala He Wing Trp Leu Gln Leu Phe Gly 50 55 60 Lys Asn Gln Gly He Asn Arg Phe Phe Gly Thr Glu Val Trp Asp He 65 70 75 80 Tyr Gly Wing Asp Gly Val Thr Phe Leu Leu He Val His Ser Tyr Pro 85 90 95 Thr Val Tyr He He Val Ser Ala Ala Leu Arg Gln Leu Pro Ser Asp 100 105 110 Leu Glu Gln Ala Ala Arg He Ala Gly Ala Asp Thr Phe Thr Val Leu 115 120 125 Arg Thr He Thr Leu Pro Leu Leu Lys Pro Wing Leu Leu Ser Wing Phe 130 135 140 Thr Leu Thr Thr Val Wing Asn Leu Wing Asp Phe Gly He Pro Wing Leu 145 150 155 160 Leu Gly Ser Pro Wing Arg Phe Glu Thr Leu Wing Thr Met He Tyr Arg 165 170 175 Phe Met Glu Ser Gly Thr Val Ser Asn Pro Leu Gln Val Val Ser Thr 180 185 190 He Gly He Val Leu Leu Phe Leu Gly He Ala Wing Val Thr Ala Asp 195 200 205 Tyr Leu Val Ser Leu Tyr Wing Wing Ser Lys Leu Gln Asp Wing Gly Thr 210 215 220 Pro His Arg Phe Thr Leu Asn Lys Ser Arg He Pro Val Ser Val He 225 230 235 240 Thr Trp He He Wing Wing Leu He He Thr Wing Wing Pro Leu Leu Gly Leu 245 250 255 Wing Tyr Arg Wing Leu Leu Pro Wing Pro Gly 260 265 < 210 > 377 < 211 > 749 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (726) < 223 > RXN01285 < 400 > 377 etc aac gtc acc ate ccc gac aac acc ttc acc gcc ate ate ggc ccc 48 Leu Asn Val Thr He Pro Asp Asn Thr Phe Thr Ala He He Gly Pro 1 5 10 15 aac ggc tgc ggc aaa tcc acc ctg etc cgc ggt ttc tcc cgc gtg etc 96 Asn Gly Cys Gly Lys Ser Thr Leu Leu Arg Gly Phe Ser Arg Val Leu 20 25 30 aat ccg cag drops ggc aaa gtg ctt etc gac ggt cgg caa etc gat tea 144 Asn Pro Gln His Gly Lys Val Leu Leu Asp Gly Arg Gln Leu Asp Ser 35 40 45 ttc aag ect aaa gag ate gcc cga gaa cta ggc ctg ctg cca cag acc 192 Phe Lys Pro Lys Glu He Wing Arg Glu Leu Gly Leu Leu Pro Gln Thr 50 55 60 tcc ate gcc cca gaa ggc ate cgg gtt tac gat etc ate gcg cgc ggg 240 Be He Wing Pro Glu Gly He Arg Val Tyr Asp Leu He Wing Arg Gly 65 70 75 80 cgc gct ccc tac cac age etc ata caá cagg tgg cgc acc tcc gac gaa 288 Arg Ala Pro Tyr Gln Ser Leu He Gln Gln Trp Arg Thr Ser Asp Glu 85 90 95 gac gcc gc gcg cac gcg etc gcc tcc acg aat etc acc gaa ctt gca 336 Asp Ala Val Ala Gln Ala Leu Ala Ser Thr Asn Leu Thr Glu Leu Ala 100 105 110 gct cgc etc gtc gat gaa etc tcc ggt ggc cag cgc caa cga gtg tgg 384 Wing Arg Leu Val Asp Glu Leu Ser Gly Gly Gln Arg Gln Arg Val Trp 115 120 125 gtg gcc atg ttg etc gcc cag caa here ccg ate atg ctt etc gac gag 432 Val Ala Met Leu Leu Ala Gln Gln Thr Pro He Met Leu Leu Asp Glu 13O 135 140 ccc acc acc ttc etc gac ate gcc falls ca ta tac gaa etc ttg gaa ttg 480 Pro Thr Thr Phe Leu Asp He Wing His Gln Tyr Glu Leu Leu Glu Leu 145 150 155 160 ctc cgc gca tcc aac gacc gc ggg aaa act gtc gtc act gtg ctt cae 528 Leu Arg Wing Phe Asn Glu Wing Gly Lys Thr Val Val Thr Val Leu His 165 170 175 gat etc aac gcc gcc gcc cc tac gcc gac drops etc gtg gtg atg aaa 576 Asp Leu Asn Gln Wing Wing Arg Tyr Wing Asp His Leu He Val Met Lys 180 185 190 gat ggg falls gta cat gcc acg ggc here ccg gag gaa gtc tta act gcc 624 Asp Gly His Val His Wing Thr Gly Thr Pro Glu Glu Val Leu Thr Wing 195 200 205 gag atg gtt ca gga gtt ttt ggc ctg ccc tgc ate ate tcc cca gac 672 Glu Met Val Gln Gly Val Phe Gly Leu Pro Cys He He Ser Pro Asp 210 215 220 ccc gtc here gga acc ccc acc gtc gtt ccc etc agt cgg tet cgc gca 720 Pro Val Thr Gly Thr Pro Thr Val Val Pro Leu Ser Arg Ser Arg Ala 225 230 235 240 gga gct taagtagcta cccctccaac gga 749 Gly Ala < 210 > 378 < 211 > 242 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 378 Leu Asn Val Thr He Pro Asp Asn Thr Phe Thr Wing He He Gly Pro 1 5 10 15 Asn Gly Cys Gly Lys Ser Thr Leu Leu Arg Gly Phe Ser Arg Val Leu 20 25 30 Asn Pro Gln His Gly Lys Val Leu Leu Asp Gly Arg Gln Leu Asp Ser 35 40 45 Phe Lys Pro Lys Glu He Wing Arg Glu Leu Gly Leu Pro Gln Thr 50 55 60 Ser Wing Pro Glu Gly He Arg Val Tyr Asp Leu He Wing Arg Gly 65 70 75 80 Arg Wing Pro Tyr Gln Ser Leu He Gln Gln Trp Arg Thr Ser Asp Glu 85 90 95 Asp Wing Val Wing Gln Wing Leu Wing Being Thr Asn Leu Thr Glu Leu Wing 100 105 110 Wing Arg Leu Val Asp Glu Leu Ser Gly Gly Glg Arg Gln Arg Val Trp 10 115 120 125 Val Wing Met Leu Leu Wing Gln Gln Thr Pro He Met Leu Leu Asp Glu 130 135 140 • Pro Thr Thr Phe Leu Asp He Wing His Gln Tyr Glu Leu Leu Glu Leu 145 150 155 160 Leu Arg Ala Phe Asn Glu Wing Gly Lys Thr Val Val Thr Val Leu His 165 170 175 Asp Leu Asn Gln Wing Wing Arg Tyr Wing Asp His Leu He Val Met Lys 180 185 190 Asp Gly His Val His Wing Thr Gly Thr Pro Glu Glu Val Leu Thr Wing 195 20 0 205 15 Glu Met Val Gln Gly Val Phe Gly Leu Pro Cys He He Ser Pro Asp 210 215 220 Pro Val Thr Gly Thr Pro Thr Val Val Pro Leu Ser Arg Ser Arg Ala 225 230 235 240 Gly Ala < 210 > 379 < 211 > 1149 < 212 > DNA • < 213 > Corynebacterium glutamicum < 220 > 20 < 221 > CDS < 222 > (101) .. (1126) < 223 > RXN00523 < 400 > 379 tggtgactcg tccgagtgaa attgccgtgg gcatcatcat gcegatcatt ggtgcgccac 60 tgtttatttg gattattegt cgtcagaaag tcaaagagct atg age ctt age cat 115 Met Ser Leu Ser His 1 5 cag etc aag cgc cag cgc gca tcg cgc aac tcc cgc agg tgg ctg att 163 Gln Leu Lys Arg Gln Arg Ala Ser Arg Asn Ser Arg Arg Trp Leu He 10 15 20 25 gtt gcg gca ttg ggc gtc gtc acg ctt ggt att ttt gct ttt tet ttg 211 (ii ftfülfi »* ^ Val Ala Ala Leu Gly Val Val Thr Leu Gly He Phe Ala Phe Ser Leu 25 30 35 atg tgg ggc gag gtg ttt tat ggc ect gct cag gtg ctg aaa gtg ttg 259 Met Trp Gly Glu Val Phe Tyr Gly Pro Ala Gln Val Leu Lys Val Leu 40 45 50 tet gga cag cag gtt ccc ggc gcg agt tat tcc gtt ggc gtg ttg cgt 307 Ser Gly Gln Gln Val Pro Gly Ala Ser Tyr Ser Val Gly Val Leu Arg 55 60 65 ttg ccg cgc gcg gtg atg ggt ttg act gcg ggt ttg gcg ttt ggc gcg 355 Leu Pro Arg Ala Val Met Gly Leu Thr Ala Gly Leu Ala Phe Gly Ala 70 75 80 85 gcg ggc gtg att ttt cag acg gtg ttg cgt aat cag ttg gcg tcg ccg 403 Wing Gly Val He Phe Gln Thr Val Leu Arg Asn Gln Leu Wing Ser Pro 90 95 100 gat att ate ggc att tet tet ggc gcg gcg gcg ggc gta att tgc 451 Asp He He Gly He Ser Ser Gly Ala Ser Ala Ala Gly Val He Cys 105 110 115 att gtg ttt ttc ggg atg tcg cag tet gca gtg tcg gcg att tet ttg 499 He Val Phe Phe Gly Met Ser Gln Ser Wing Val Ser Wing He Ser Leu 120 125 130 tgt gcg tcc ttg gct gtg gcg ttg ttg att tat ctg gtg gc g tat cgc 547 Cys Wing Ser Leu Wing Val Wing Leu Leu He Tyr Leu Val Wing Tyr Arg 135 140 145 ggt ggt ttt tcg gcc acg cgt ctg att ctt acc ggc att ggt att gct 595 Gly Gly Phe Ser Ala Thr Arg Leu He Leu Thr Gly He Gly He Ala 150 155 160 165 gcg atg ctg aat tea tta gtg tcg tat tcg ctg tcc aag gct gat tet 643 Wing Met Leu Asn Ser Leu Val Ser Tyr Ser Leu Ser Lys Wing Asp Ser 170 175 180 tgg gat ctg ccg acc gcg acg cgc tgg ctt acc ggc tcg etc aat ggt 691 Trp Asp Leu Pro Thr Ala Thr Arg Trp Leu Thr Gly Ser Leu Asn Gly 185 190 195 gcg acg tgg gat cgt gcg atg ccg ctg att gtc acc act gtg gta etc 739 Wing Thr Trp Asp Arg Wing Met Pro Leu He Val Thr Thr Val Val Leu 200 205 210 att ccg ctg ctg gtg gct aat gcg cgc aat gtg gat ctt atg cgt ttg 787 He Pro Leu Leu Val Ala Asn Ala Arg Asn Val Asp Leu Met Arg Leu 215 220 225 ggc aat gat tcc gcg gtg gt ggc gtt gct act aat cgc acg cgc 835 Gly Asn Asp Ser Wing Val Gly Leu Gly Val Wing Thr Asn Arg Thr Arg 230 235 240 245 gtc att gcg att att gcc gct gtt gcg etc ate gcc gtt gct acc gct 883 Val He Ala He Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala W Ala Val Ala Phe Val Ser Gly Pro He Wing 265 270 275 gcg cgc att tta ggc tcc ggc gga tcg etc ate ate ccc tcc gca etc 979 Wing Arg He Leu Gly Ser Gly Gly Ser Leu He He Pro Ser Ala Leu 280 285 290 ate ggc ggg ttg ate gtg etc ate gcc gac cta att ggc ca ta tac ttc 1027 He Gly Gly Leu He Val Leu He Wing Asp Leu He Gly Gln Tyr Phe 295 300 305 etc ggc acc cgc tac ccc gtc gga gtc gtc acc ggc gca tcc ggc gcc 1075 Leu Gly Thr Arg Tyr Pro Val Gly Val Val Thr Gly Ala Phe Gly Ala 310 315 320 325 cca ttc ctt ate tat tta etc att cgt tcc aac cgc gcg gga gta acc 1123 .Jr t.

Pro Phe Leu He Tyr Leu Leu He Arg Ser Asn Arg Wing Gly Val Thr 330 335 340 ctg tgaccaccaa ccatcaacta tcc 1149 Leu < 210 > 380 < 211 > 342 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 380 Met Ser Leu Ser His Gln Leu Lys Arg Gln Arg Wing Being Arg Asn Being 1 5 10 15 Arg Arg Trp Leu He Val Wing Wing Leu Gly Val Val Thr Leu Gly He 20 25 30 Phe Ala Phe Ser Leu Met Trp Gly Val Glu Phe Tyr Gly Pro Wing Gln 35 40 45 Val Leu Lys Val Leu Ser Gly Gln Gln Val Pro Gly Wing Ser Tyr Ser 50 55 60 10 Val Gly Val Leu Arg Leu Pro Arg Ala Val Met Gly Leu Thr Ala Gly 65 70 75 80 Leu Wing Phe Gly Wing Wing Gly Val He Phe Gln Thr Val Leu Arg Asn 85 90 95 • Gln Leu Wing Ser Pro Asp He He Gly He Ser Ser Gly Wing Ser Wing 100 105 110 Wing Gly Val He Cys He Val Phe Phe Gly Met Ser Gln Ser Ala Val 115 120 125 Ser Ala Be Ser Leu Cys Ala Ser Leu Ala Val Ala Leu Leu He Tyr 130 135 140 Leu Val Ala Tyr Arg Gly Gly Phe Ser Ala Thr Arg Leu He Leu Thr 145 150 155 160 15 Gly He Gly He Wing Wing Met Leu Asn Ser Leu Val Ser Tyr Ser Leu 165 170 175 Ser Lys Wing Asp Ser Trp Asp Leu Pro Thr Wing Thr Arg Trp Leu Thr 180 185 190 Gly Ser Leu Asn Gly Wing Thr Trp Asp Arg Wing Met Pro Leu He Val 195 200 205 Thr Thr Val Val Leu He Pro Leu Leu Val Wing Asn Wing Arg Asn Val 210 215 220 Asp Leu Met Arg Leu Gly Asn Asp Being Wing Val Gly Leu Gly Val Wing • 225 230 235 240 Thr Asn Arg Thr Arg Val He Wing He Wing Wing Wing Val Wing Leu He 245 250 255 20 Wing Val Wing Thr Wing Wing Cys Gly Pro He Wing Phe Val Wing Phe Val 260 265 270 Ser Gly Pro He Wing Wing Arg He Leu Gly Ser Gly Gly Ser Leu He 275 280 285 He Pro Be Wing Leu He Gly Gly Leu He Val Leu He Wing Asp Leu 290 295 300 He Gly Gln Tyr Phe Leu Gly Thr Arg Tyr Pro Val Gly Val Val Thr 305 310 315 320 Gly Wing Phe Gly Wing Pro Phe Leu He Tyr Leu Leu He Arg Ser Asn 325 330 335 Arg Ala Gly Val Thr Leu 340 25 <; 210 > 381 < 211 > 621 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (598) < 223 > RXN01142 < 400 > 381 ctccccatcc; accggcacag ticagcgcagg caaegaagaa att; aaaggac < ? aggacctga 60 ccgaggcatg tgttttccaag atrcacgccct cctgccctga ttg acc gca cgc ggc 115 Leu Thr Ala Arg Gly 1 5 aac ate gac ttc ggg etc cgc tcc gcg cgc ccc tcc ttg age aaa acc 163 Asn He Asp Phe Gly Leu Arg Ser Ala Arg Pro Ser Leu Be Lys Thr 10 15 20 gaa cgc gcc gac ate acc cgc acc falls etc gaa cata gta ggc etc acc 211 Glu Arg Wing Asp He Thr Arg Thr His Leu Glu Gln Val Gly Leu Thr 10 25 30 35 gac gcc gcc gaa cgg cgc ccc gcc cgc etc tcc ggc ggc atg cag cag 259 Asp Ala Ala Glu Arg Arg Pro Ala Arg Leu Ser Gly Gly Met Gln Gln 40 45 50 • cga gtc ggc ate gca cgc gcc ttc gcc ate gac cca cca ate atg ctt 307 Arg Val Gly He Wing Arg Ala Phe Wing He Asp Pro Pro He Met Leu 55 60 65 etc gac gaa ccc ttc ggc gcc etc gac gcc etc acc cgc cgc gaa etc 355 Leu Asp Glu Pro Phe Gly Ala Leu Asp Ala Leu Thr Arg Arlu Glu Leu 70 75 80 85 cag etc caá cta etc aac att tgg gaa gcc tcc cgc cgc acc gtc gtc 403 Gln Leu Gln Leu Leu Asn He Trp Glu Wing Being Arg Arg Thr Val Val 15 90 95 100 atg gtc acc ae gac gtc gac gag gcc ate ctg etc tcc gac cga gtt 451 Met Val Thr His Asp Val Asp Glu Ala He Leu Leu Ser Asp Arg Val 105 110 115 etc gtg atg tcc aag age ccc gaa gcc acc ate ate acc ata att cca 499 Leu Val Met Ser Lys Ser Pro Glu Wing Thr He He Thr Asp He Pro 120 125 130 gtg aat ctt ccc cgc ccc aga cae gag ctg agt gaa gac gct tet gtt 547 Val Asn Leu Pro Arg Pro Arg His Glu Leu Ser Glu Asp Ala Ser Val • 135 140 145 gaa gcc gag acc gcc ctg cgt aag cgt aag cgg cgg cat ctg ctg gag 595 Glu Ala Glu Thr Thr Ala Leu Arg Lys Arg Met Leu His Leu Leu Glu 20 150 155 160 165 cae tagt -.ttctaa caegt • .ctttt aaa 621 His < 210 > 382 < 211 > 166 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 382 Leu Thr Ala Arg Gly Asn He Asp Phe Gly Leu Arg Be Ala Arg Pro 25 1 5 10 15 *,. , _ ^ ^ & A *? AJ Ser Leu Ser Lys Thr Glu Arg Wing Asp He Thr Arg Thr His Leu Glu 20 25 30 Gln Val Gly Leu Thr Asp Wing Wing Glu Arg Arg Pro Wing Arg Leu Ser 35 40 45 Gly Gly Met Gln Gln Arg Val Gly He Ala Arg Ala Phe Ala He Asp 50 55 60 Pro Pro He Met Leu Leu Asp Glu Pro Phe Gly Ala Leu Asp Ala Leu 65 70 75 80 Thr Arg Arg Glu Leu Gln Leu Gln Leu Leu Asn He Trp Glu Wing Be 85 90 95 Arg Arg Thr Val Val Met Val Thr His Asp Val Asp Glu Ala He Leu 100 105 110 Leu Ser Asp Arg Val Leu Val Met Ser Lys Ser Pro Glu Ala Thr He 115 120 125 He Thr Asp He Pro Val Asn Leu Pro Arg Pro Arg His Glu Leu Ser 130 135 140 Glu Asp Ala Ser Val Glu Ala Glu Thr Thr Ala Leu Arg Lys Arg Met 145 150 155 160 Leu His Leu Leu Glu His 165 < 210 > 383 < 211 > 948 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (925) < 223 > RXN01141 < 400 > 383 aaaigaacact < cggtatggt: a cctgatttaa ggatgctgca atcgtgacac atatectett 60 cgaieagc; agg < cgttttctgc aactgggcgc ttttgcgtcc ttg age acc gca ttg 115 Leu Ser Thr Ala Leu 1 5 gcc ggc gcg gcc cgc tac gtg acg tcg here age aat aat gaa ect gcg 163 Wing Wing Wing Wing Arg Tyr Val Thr Ser Thr Ser Asn Asn Glu Pro Wing 10 15 20 gat aac act ccc ctg acc att ggc tac gtg ect att gcg ggc tcg gcg 211 Asp Asn Thr Pro Leu Thr He Gly Tyr Val Pro He Wing Gly Be Wing 25 30 35 ccg att gct ate gca gat gcg cta ggg ctg ttt aag aaa fall ggc gtg 259 Pro He Wing Wing Wing Asp Wing Leu Gly Leu Phe Lys Lys His Gly Val 40 45 50 aat gtc acg ttg aag aag tac tea ggc tgg tcc gac ctg tgg acc gcc 307 Asn Val Thr Leu Lys Lys Tyr Ser Gly Trp Ser Asp Leu Trp Thr Wing 55 60 65 tat gca here gag cag ctt gat gtt gcg drops atg ctg tcg ccg atg act 355 Tyr Ala Thr Glu Gln Leu Asp Val Ala His Met Leu Ser Pro Met Thr 70 75 80 85 gtg gcg att aat gct gga gtg acc aac gcg tcg cgc ccg acg gag ctg 403 Val Ala He Asn Wing Gly Val Thr Asn Wing Ser Arg Pro Thr Glu Leu 90 95 100 tcg ttt acc cag aac acc aat ggg ca gca att acc ttg gcg tea aag 451 Be Phe Thr Gln Asn Thr Asn Gly Gln Wing He Thr Leu Wing Ser Lys 105 110 115 fall tat ggt tcc gtc aat tea gcg gcg gat ctt aaa ggc atg gtg ctg 499 His Tyr Gly Ser Val Asn Ser Ala Ala Asp Leu Lys Gly Met Val Leu 120 125 130 gga att ect ttt gaa tat tea gtc cat gcg ctg etc ctg cgc gat tat 547 Gly He Pro Phe Glu Tyr Ser Val His Wing Leu Leu Leu Arg Asp Tyr 135 140 145 etc gtc tea aac gca gtt gat ccc ate gcc gat ctt gag ctt cgc ctg 595 Leu Val Ser Asn Ala Val Asp Pro He Wing Asp Leu Glu Leu Arg Leu 150 155 160 165 etc cga ect gcc gat atg gtc gca cat ttg here gtt gag ggc ate gat 643 Leu Arg Pro Wing Asp Met Val Ala Gln Leu Thr Val Glu Gly He Asp 170 175 180 gga ttc att ggg ect ggg ccg ttt aat gaa cgc gcc ate age aat ggc 691 Gly Phe He Gly Pro Gly Pro Phe Asn Glu Arg Ala He Ser Asn Gly 185 190 195 tcc ggc cgg att tgg ctg ctg acc aaa caa ctg tgg gac aaa cat cca 739 Ser Gly Arg He Trp Leu Leu Thr Lys Gln Leu Trp Asp Lys His Pro 200 205 210 tgc tgc gcc gtg gcg atg gcc aaa gag tgg aaa gct gaa falls ccc acg 787 Cys Cys Wing Wing Ala Wing Wing Lys Glu Trp Lys Wing Glu His Pro Thr 215 220 225 10 gcg gct cag ggt gtg ctt aat gcg ctg gag gaa gcc tcc gca att ttg 835 Wing Wing Gln Gly Val Leu Asn Ala Leu Glu Glu Ala Wing Wing He Leu • 230 235 240 245 age aat ccg gca cata ttt gat tcc tcg gca cgc acg ctg tcg cag gaa 883 Ser Asn Pro Wing Gln Phe Asp Ser Wing Arg Thr Leu Ser Gln Glu 250 255 260 aaa tac etc aac cag ect gcc acg ttg ctg gat gga ccg tcg 925 Lys Tyr Leu Asn Gln Pro Wing Thr Leu Leu Asp Gly Pro Ser 265 270 275 taatcategg catcaccggc tta 948 < 210 > 384 15 < 211 > 275 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 384 Leu Ser Thr Ala Leu Ala Gly Ala Ala Arg Tyr Val Thr Ser Thr Ser 1 5 10 15 • Asn Asn Glu Pro Wing Asp Asn Thr Pro Leu Thr He Gly Tyr Val Pro 20 25 30 He Wing Gly Wing Pro Wing He Wing Wing Asp Wing Leu Gly Leu Phe 35 40 45 Lys Lys His Gly Val Asn Val Thr Leu Lys Lys Tyr Ser Gly Trp Ser 20 50 55 60 Asp Leu Trp Thr Wing Tyr Wing Thr Glu Gln Leu Asp Val Wing His Met 65 70 75 80 Leu Ser Pro Met Thr Val Wing He Asn Wing Gly Val Thr Asn Wing Ser 85 90 95 Arg Pro Thr Glu Leu Ser Phe Thr Gln Asn Thr Asn Gly Gln Wing He 100 105 110 Thr Leu Wing Ser Lys His Tyr Gly Ser Val Asn Ser Wing Wing Asp Leu 115 120 125 Lys Gly Met Val Leu Gly He Pro Phe Glu Tyr Ser Val His Ala Leu 130 135 140 Leu Leu Arg Asp Tyr Leu Val Ser Asn Ala Val Asp Pro He Ala Asp 25 . ¿, ,. 1 ,. 145 150 155 160 Leu Glu Leu Arg Leu Leu Arg Pro Wing Asp Met Val Wing Gln Leu Thr 165 170 175 Val Glu Gly He Asp Gly Phe He Gly Pro Gly Pro Phe Asn Glu Arg 180 185 190 Wing He Be Asn Gly Be Gly Arg He Trp Leu Leu Thr Lys Gln Leu 195 200 205 Trp Asp Lys His Pro Cys Cys Ala Val Ala Met Ala Lys Glu Trp Lys 210 215 220 Ala Glu His Pro Thr Ala Ala Gln Gly Val Leu Asn Ala Leu Glu Glu 225 230 235 240 Wing Being Wing He Leu Being Asn Pro Wing Gln Phe Asp Being Wing Arg 245 250 255 Thr Leu Ser Gln Glu Lys Tyr Leu Asn Gln Pro Wing Thr Leu Leu Asp 260 265 270 Gly Pro Ser 275 < 210 > 385 < 211 > 927 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (904) < 223 > RXN01002 < 400 > 385 gactgctgat accgcacagg atgaa; atcac tcgttacggc gagatcctga; agaagttetc 60 caactaattt < ccctgtttcc aatactcaag gtgtgcgcat atg aat tet gat gct 115 Met Asn Ser Asp Wing 1 5 tcg gct acc acac tcc tgg gct ate aac ttc gac cat gtg tcg gtg 163 Be Wing Thr Thr Asn Ser Trp Wing He Asn Phe Asp His Val Ser Val 10 15 20 acg tat ccc aat ggg acg aaa gcc etc gat gat gtt tcc etc acc ate 211 Thr Tyr Pro Asn Gly Thr Lys Wing Leu Asp Asp Val Ser Leu Thr He 25 30 35 aat ccc ggt gag atg gtt gcc ate gtg ggt ctg tea gga tcg ggt aaa 259 Asn Pro Gly Glu Met Val Wing He Val Gly Leu Ser Gly Ser Gly Lys 40 45 50 tcc acg ctg att cgc acg ate aac ggt ctt gtc cgc gct acg gaa ggc 307 Be Thr Leu He Arg Thr He Asn Gly Leu Val Arg Ala Thr Glu Gly 55 60 65 acc gtg acg gtg ggg ccg cat cag ate aac acc ttg aag ggg aaa gca 355 Thr Val Thr Val Gly Pro His Gln He Asn Thr Leu Lys Gly Lys Ala 70 75 80 85 ctg cgt gat gcc cgt ggg cag ate ggc atg att ttc cag ggg ttc aac 403 Leu Arg Asp Wing Arg Gly Gln He Gly Met He Phe Gln Gly Phe Asn 90 95 100 ctg tcg gaa cgc age agt gtg ttc cag aat gtt ttg gtg ggc cgc ttc 451 Leu Ser Glu Arg Be Ser Val Phe Gln Asn Val Leu Val Gly Arg Phe 105 110 115 gcg drop here gcg tgg tgg cgt aac etc etc ggg ttt ccc acg gag drops 499 Ala His Thr Ala Trp Trp Arg Asn Leu Leu Gly Phe Pro Thr Glu His 120 125 130 gac aag cag att gct ttt falls gcg ttg gag tcc gtg ggc att ttg drops 547 Asp Lys Gln He Ala Phe His Ala Leu Glu Ser Val Gly He Leu His 135 140 145 aaa gtg tgg acc gga gct gct gct ggt gga cag aaa cag cgc 595 Lys Val Trp Thr Arg Ala Gly Ala Leu Ser Gly Gly Gln Lys Gln Arg 150 155 160 165 gtt gct att gcg cgc gcc tta tcg ca gat gat ccg tet gtc atg ctg gca 643 Val Wing Wing Wing Arg Wing Leu Ser Gln Asp Pro Ser Val Met Leu Wing 170 175 180 gat gag ect gtg gca age ctt gat ccg cca acc gcg cat tcc gtg atg 691 Asp Glu Pro Val Wing Ser Leu Asp Pro Pro Thr Wing His Ser Val Met 185 190 195 cgc gat cta gaa aac ate aac aac gtg gaa ggc etc acc gtg ttg gtg 739 Arg Asp Leu Glu Asn He Asn Asn Val Glu Gly Leu Thr Val Leu Val 200 205 210 aac ttg falls ttg att gat ttg gct cgt ca ta tac ac agg ctt gtg 787 Asn Leu His Leu He Asp Leu Ala Arg Gln Tyr Thr Thr Arg Leu Val 215 220 225 ggt tgc ggc ggc gcg gtc gtc g tat c ggt ect ate tet gag gcc 835 Gly Leu Arg Wing Gly Lys Leu Val Tyr Asp Gly Pro He Ser Glu Wing 10 230 235 240 245 acc gat aaa gac ttt gaa gct ate tat ggt cgc ccc ate cag gct aaa 883 Thr Asp Lys Asp Phe Glu Wing He Tyr Gly Arg Pro He Gln Wing Lys 250 255 260 • gac ctg cta ggt gat cgc gca tgaccacgcc ttettetaca ctt 927 Asp Leu Leu Gly Asp Arg Ala 265 < 210 > 386 < 211 > 268 < 212 > PRT < 213 > Corynebacterium glutamicum 15 < 400 > 386 Met Asn Ser Asp Wing Ser Wing Thr Thr Asn Ser Trp Wing He Asn Phe 1 5 10 15 Asp His Val Ser Val Thr Tyr Pro Asn Gly Thr Lys Wing Leu Asp Asp 20 25 30 Val Ser Leu Thr He Asn Pro Gly Glu Met Val Ala He Val Gly Leu 35 40 45 Ser Gly Ser Gly Lys Ser Thr Leu He Arg Thr He Asn Gly Leu Val • 50 55 60 Arg Wing Thr Glu Gly Thr Val Thr Val Gly Pro His Gln He Asn Thr 65 70 75 80 Leu Lys Gly Lys Wing Leu Arg Asp Wing Arg Gly Gln He Gly Met He 20 85 90 95 Phe Gln Gly Phe Asn Leu Ser Glu Arg Ser Ser Val Phe Gln Asn Val 100 105 110 Leu Val Gly Arg Phe Wing His Thr Wing Trp Trp Arg Asn Leu Leu Gly 115 120 125 Phe Pro Thr Glu His Asp Lys Gln He Wing Phe His Wing Leu Glu Ser 130 135 140 Val Gly He Leu His Lys Val Trp Thr Arg Wing Gly Wing Leu Ser Gly 145 150 155 160 Gly Gln Lys Gln Arg Val Wing He Wing Arg Wing Leu Ser Gln Asp Pro 165 170 175 25 Ser Val Met Leu Wing Asp Glu Pro Val Wing Ser Leu Asp Pro Pro Thr 180 185 190 Wing His Ser Val Met Arg Asp Leu Glu Asn He Asn Asn Val Glu Gly 195 200 205 Leu Thr Val Leu Val Asn Leu His Leu He Asp Leu Wing Arg Gln Tyr 210 215 220 Thr Thr Arg Leu Val Gly Leu Arg Wing Gly Lys Leu Val Tyr Asp Gly 225 230 235 240 Pro He Ser Glu Wing Thr Asp Lys Asp Phe Glu Wing He Tyr Gly Arg 245 250 255 Pro He Gln Wing Lys Asp Leu Leu Gly Asp Arg Wing 260 265 < 210 > 387 < 211 > 969 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (946) < 223 > RXN01000 < 400 > 387 ctttctatgc ttacgcggat gtttccgtg; a tcattctgga aatcetc; ate gtggtgattg 60 tcattgaagt; aatctccaac geaettega; a ag; aggdtggt atg age acc tta acc 115 Met Ser Thr Leu Thr 1 5 tet falls cgc here gta ccg gcc ccc age tet ccc ccg gcg cgc ccc aac 163 Ser His Arg Thr Val Pro Pro Wing Pro Pro Pro Wing Arg Pro Asn 10 15 20 aaa ctg gcg cgc aat ate gtt gca att gtc gct gcg ctg att gtc ctt 211 Lys Leu Wing Arg Asn He Val Wing Wing Val Wing Wing Leu He Val Leu 25 30 35 ata gct acc ggc acg etc aag ate gag tgg aat gag ctt ccg cag atg 259 He Ala Thr Gly Thr Leu Lys He Glu Trp Asn Glu Leu Pro Gln Met 40 45 50 ccc gcg cag gtg tgg cat tac tta gag ctg atg ttt age gat ccc gat 307 Pro Ala Gln Val Trp His Tyr Leu Glu Leu Met Phe Ser Asp Pro Asp 55 60 65 tgg tcg aag ttt ggc cgc gcc gtc cag gaa atg tgg cgt tcc ate gcc 355 Trp Ser Lys Phe Gly Arg Wing Val Gln Glu Met Trp Arg Ser Wing 70 75 80 85 atg gcg tgg ttg ggt gcc att tta tgc gtg gtg gtc tet gtc ect ctg 403 Met Ala Trp Leu Gly Ala He Leu Cys Val Val Val Ser Val Pro Leu 90 95 100 gga atg ttg gct gcc cgc ggg gtg gga ect tat tgg ctg cgt acc gtt 451 Gly Met Leu Wing Wing Arg Gly Val Gly Pro Tyr Trp Leu Arg Thr Val 105 110 115 tta cgg ttc gtg ttc gcg gtg att cgt gcg ttc ccc gaa gtg gtt ate 499 Leu Arg Phe Val Phe Ala Val He Arg Ala Phe Pro Glu Val Val He 120 125 130 gca att att ttg cta act gtc acc ggc cta act ect ttt act ggt gcg 547 Ala He He Leu Leu Thr Val Thr Gly Leu Thr Pro Phe Thr Gly Ala 135 140 145 etc gca ttg ggt ate tcc ggt att gga caa cag gca aag tgg acc tat 595 Leu Ala Leu Gly He Ser Gly He Gly Gln Gln Ala Lys Trp Thr Tyr 150 155 160 165 gaa gcc att gag tcc act ccc acc ggc ccg tea gag gca gtg cgt gca 643 Glu Wing He Glu Be Thr Pro Thr Gly Pro Ser Glu Wing Val Arg Wing 170 175 180 gcg ggt gga act acg ccg gag gtt ctg cgg tgg gcg ttg tgg cca cag 691 Wing Gly Gly Thr Thr Pro Glu Val Leu Arg Trp Wing Leu Trp Pro Gln 185 190 195 gtt gcg cca tcc att gca tet ttt gcc ctg tac cgc ttt gag ate aac 739 Val Ala Pro Ser He Ala Be Phe Ala Leu Tyr Arg Phe Glu He Asn 200 205 210 ate cgt acc tet gcg gta ttg ggc ate gtt ggt gca ggt ggt ate ggt 787 He Arg Thr Ser Wing Val Leu Gly He Val Gly Wing Gly Gly He Gly 215 220 225 agt atg ctt gcc aat tac acc aac tac agg cag tgg gac acc gtg ggc 835 Being Met Leu Ala Asn Tyr Thr Asn Tyr Arg Gln Trp Asp Thr Val Gly 230 235 240 245 atg ctg etc ate gtc gtg gtt gtc gca acg atg ate gtc gat etc ate 883 Met Leu Leu He Val Val Val Val He Thr Met He Val Asp Leu He 250 255 260 tcc ggc acc ate cgc cgc cgc ate atg aag ggg gct agt gac cgt gtc 931 Ser Gly Thr He Arg Arg Arg He Met Lys Gly Wing Being Asp Arg Val 265 270 275 gtg gca cca age aac tgacgctcca ccaagcatcc gca 969 Val Ala Pro Ser Asn 280 < 210 > 386 < 211 > 282 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 388 Met Ser Thr Leu Thr Ser His Arg Thr Val Pro Pro Wing Ser Pro 1 5 10 15 Pro Wing Arg Pro Asn Lys Leu Wing Arg Asn He Val Wing He Val Wing 20 25 30 Wing Leu He Val Leu He Wing Thr Gly Thr Leu Lys He Glu Trp Asn 35 40 45 Glu Leu Pro Gln Met Pro Wing Gln Val Trp His Tyr Leu Glu Leu Met 50 55 60 Phe Ser Asp Pro Asp Trp Ser Lys Phe Gly Arg Ala Val Gln Glu Met 65 70 75 80 Trp Arg Be He Ala Ala Ala Trp Leu Gly Ala He Leu Cys Val Val 85 90 95 Val Ser Val Pro Leu Gly Met Leu Ala Ala Arg Gly Val Gly Pro Tyr 100 105 110 Trp Leu Arg Thr Val Leu Arg Phe Val Phe Ala Val He Arg Wing Phe 115 120 125 Pro Glu Val Val He Wing He He Leu Leu Thr Val Thr Gly Leu Thr 130 135 140 Pro Phe Thr Gly Wing Leu Wing Leu Gly He Ser Gly He Gly Gln Gln 145 150 155 160 Wing Lys Trp Thr Tyr Glu Wing He Glu Be Thr Pro Thr Gly Pro Ser 165 170 175 Glu Wing Val Arg Wing Wing Gly Gly Thr Thr Pro Glu Val Leu Arg Trp 180 185 190 Wing Leu Trp Pro Gln Val Wing Pro Ser Wing Be Phe Wing Leu Tyr 195 200 205 , i, .- I «< iér.

Arg Phe Glu He Asn He Arg Thr Ser Wing Val Leu Gly He Val Gly 210 215 220 Wing Gly Gly He Gly Ser Met Leu Wing Asn Tyr Thr Asn Tyr Arg Gln 225 230 235 240 Trp Asp Thr Val Gly Met Leu Leu He Val Val Val Val Ala Thr Met 245 250 255 He Val Asp Leu He Ser Gly Thr He Arg Arg Arg He Met Lys Gly 260 265 270 Wing Being Asp Arg Val Val Wing Pro Ser Asn 275 280 < 210 > 389 < 211 > 1173 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1150) < 223 > RXN01732 < 400 > 389 gattcta-tcg ictgatctccc tictccttgcc tgggttltgtt cccgggtctc < ? tcttcttaa 60 ctttcttgtc -tcatgtcgct gaaaggtttt taaagatctc atg ttc aag etc tet 115 Met Phe Lys Leu Ser 1 5 aag cca tcc aag tcc atg cgt gtt gct gtt tet acg ctt gcg ate tet 163 Lys Pro Ser Lys Ser Met Arg Val Wing Val Ser Thr Leu Wing Be Ser 10 15 20 acc ctt gct cta gtt ggt tgt tcc tet tcc gat gag tet tet tcc tea 211 Thr Leu Wing Leu Val Gly Cys Being Ser Asp Glu Being Ser 25 30 35 tea tet gcg tet tet tet tcg gat gct age cag tgg ect gag tcc 259 Being Being Wing Being Being Being Asp Wing Wing Being Gln Trp Pro Glu Being 40 45 50 att act ttg tet ctt gtt ect tet act gag ggt gag gat ttg gct gaa 307 He Thr Leu Ser Leu Val Pro Ser Thr Glu Glu Glu Asp Leu Wing Glu 55 60 65 gcg ttg gct ect ttg act gat tac ctg tet gag aac ctt ggt att gag 355 Ala Leu Ala Pro Leu Thr Asp Tyr Leu Ser Glu Asn Leu Gly He Glu 70 75 80 85 gtc aat ggt gtg gtg gcg tet gat tac gct gca acc gtt gag gct ttg 403 Val Asn Gly Val Val Wing As Asp Tyr Wing Wing Thr Val Glu Wing Leu 90 95 100 ggt gct gat cag gct cag gtg ate ate act gat gcg ggt tcc ctg tat 451 Gly Wing Asp Gln Wing Gln Val He He Thr Asp Wing Gly Ser Leu Tyr 105 110 115 aac gcg att gag cag tac gat gcg cag ctg att ctg cgt gat gtg cgt 499 Asn Ala He Glu Gln Tyr Asp Ala Gln Leu He Leu Arg Asp Val Arg 120 125 130 ttc ggt gcc acc tcg tac tet gct gtg gcg tac acc aac aat ect gat 547 Phe Gly Wing Thr Ser Tyr Ser Wing Val Wing Tyr Thr Asn Asn Pro Asp 135 140 145 aag tac tgc gac gat gcc cca gtg gct gcg tet tat gct gcg tcc gat 595 Lys Tyr Cys Asp Asp Wing Pro Val Wing Wing Ser Tyr Wing Wing Ser Asp 150 155 160 165 gta gac atg ctt tac tgc aac ggt att gaa act gag ggc cag gct gct 643 Val Asp Met Leu Tyr Cys Asn Gly He Glu Thr Glu Gly Gln Ala Wing 170 175 180 acc ggt gag ggc cca gca gct ctt gat gcg ctg gaa aag ate gag tcc 691 Thr Gly Glu Gly Pro Wing Wing Leu Asp Wing Leu Glu Lys He Glu Ser 185 190 195 ggt gac aag gta gcg ctg cag gct gca acc tet ect gcg ggt tac cag 739 Gly Asp Lys Val Wing Leu Gln Wing Wing Thr Ser Pro Wing Gly Tyr Gln 200 205 210 tac ect ate gtc gct atg cag gat ctg ggc atg gat acc gatct tcc gct 787 Tyr Pro He Val Wing Met Gln Asp Leu Gly Met Asp Thr Asp Ser Wing 215 220 225 ttt gtt cag gtt cca gta gag ggc aac aac aac gct gtg ctg tet gtc 835 Phe Val Gln Val Pro Val Glu Gly Asn Asn Asn Wing Val Leu Ser Val 230 235 240 245 ctg aac ggt gac gcg gaa gtg tcc ttc ggt ttc tgg gat gcg cgt tcc 883 Leu Asn Gly Asp Wing Glu Val Ser Phe Gly Phe Trp Asp Wing Arg Ser 250 255 260 ctg gtg tet gag gct ect aac gca gct gag gat gtc gta gcg gtg ttt 931 Thr Val Leu Ser Glu Ala Pro Asn Ala Ala Glu Asp Val Val Ala Phe 265 270 275 gcc tac acc gag atg ate ect aac ggt ggc gtc gca gcg tcc aag tcc 979 Wing Tyr Thr Glu Met He Pro Asn Gly Gly Val Wing Wing Ser Lys Ser 280 285 290 ctt cca ccc tc gac ctg gtg gaa aag etc. acc gag ttg atg gat gat tac 1027 Leu Pro Ser Asp Leu Val Glu Lys Leu Thr Glu Leu Met Asp Asp Tyr 295 300 305 gca gat tcc gag gaa gcc aag gat gtc atg ttc gac atg gtt ggt 1075 Wing Asp Ser Ser Glu Glu Wing Lys Asp Val Met Phe Asp Met Val Gly 310 315 320 325 ct tet gac tgg act gct gat acc gca cag gat gaa ate act cgt tac 1123 Leu Ser Asp Trp Thr Wing Asp Thr Wing Gln Asp Glu He Thr Arg Tyr 330 335 340 ggc gag ate ctg aag aag ttc tcc aac taatttccct gtttccaata 1170 Gly Glu He Leu Lys Lys Phe Ser Asn 345 350 etc 1173 < 210 > 390 < 211 > 350 < 212 > PRT < 213 > Corynebacterium glutamicum <; 400 > 390 Met Phe Lys Leu Ser Lys Pro Ser Lys Ser Met Arg Val Wing Val Ser 1 5 10 15 Thr Leu Wing He Ser Thr Leu Wing Leu Val Gly Cys Ser Ser As Asp 20 25 30 Glu Being Being Being Being Wing Being Being Be Ser Asp Ala Ala Be 35 40 45 Gln Trp Pro Glu Be He Thr Leu Be Leu Val Pro Be Thr Glu Gly 50 55 60 Glu Asp Leu Ala Glu Ala Leu Ala Pro Leu Thr Asp Tyr Leu Ser Glu 65 70 75 80 Asn Leu Gly He Glu Val Asn Gly Val Val Wing As Asp Tyr Wing Wing 85 90 95 Thr Val Glu Wing Leu Gly Wing Asp Gln Wing Gln Val He He Thr Asp 100 105 110 •••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••• Asp Lys Tyr Cys Asp Asp Ala Pro Val Ala Ala Be 145 150 155 160 Tyr Wing Wing Asp Val Asp Met Leu Tyr Cys Asn Gly He Glu Thr 165 170 175 • Glu Gly Gln Wing Wing Thr Gly Glu Gly Pro Wing Ala Leu Asp Wing Leu 180 185 190 Glu Lys He Glu Ser Gly Asp Lys Val Wing Leu Gln Wing Wing Thr Ser 195 200 205 Pro Wing Gly Tyr Gln Tyr Pro He Val Wing Met Gln Asp Leu Gly Met 210 215 220 Asp Thr Asp Ser Wing Phe Val Gln Val Pro Val Glu Gly Asn Asn Asn 225 230 235 240 Wing Val Leu Ser Val Leu Asn Gly Asp Wing Glu Val Ser Phe Gly Phe 245 250 255 Trp Asp Wing Arg Ser Thr Val Leu Ser Glu Wing Pro Asn Wing Wing Glu 260 265 270 10 Asp Val Val Ala Phe Ala Tyr Thr Glu Met He Pro Asn Gly Gly Val 275 280 285 Wing Wing Ser Lys Ser Leu Pro Ser Asp Leu Val Glu Lys Leu Thr Glu 290 295 300 Leu Met Asp Asp Tyr Wing Asp Ser Ser G lu Glu Ala Lys Asp Val Met 305 310 315 320 Phe Asp Met Val Gly Leu Ser Asp Trp Thr Wing Asp Thr Wing Gln Asp 325 330 335 Glu He Thr Arg Tyr Gly Glu He Leu Lys Lys Phe Ser Asn 340 345 350 < 210 > 391 15 < 211 > 903 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (880) < 223 > RXN03080 • < 400 > 391 cttgcaaaca ggcgtggtgg tggcgttcat tggctcacca attttccttt atttactgct 60 cagcatgcgc aagcgacgcg gattggggct gtaaaaactc atg ect caa tta gtt 115 20 Met Pro Gln Leu Val 1 5 gaa att cgt gat etc aac gtt gaa ttc ccc tet cgc cat gca gtg aaa 163 Glu He Arg Asp Leu Asn Val Glu Phe Pro Ser Arg His Wing Val Lys 10 15 20 aac gtg tet ttt tet gca ect gct gga aaa gtc gtc gtc action ggc gtc 211 Asn Val Ser Phe Be Wing Pro Wing Gly Lys Val Thr Ala Leu He Gly 25 30 35 cca aat ggt ggt ggt aaa agt act gcc ctt tcg gcg att gca gga ttg 259 Pro Asn Gly Wing Gly Lys Ser Thr Wing Leu Wing Wing Wing Gly Leu 40 45 50 gtt gaa tcc acc ggc gag gt atg gtt ggg ggg ggg gtt gtt gcg tcg 307 25 Val Glu Ser Thr Gly Glu Val Val Met Val Gly Gly Ser Gly Val Ala Ser . 55 60 65 aaa age gct aaa gcc cga gcc cgc ctg etc tea etc gtg ccg caac aac 355 Lys Ser Ala Lys Ala Arg Ala Arg Leu Leu Ser Leu Val Pro Gln Asn 70 75 80 85 acc gag ttg cgc att ggt ttt agt gca cgc gac gtt gcg gcg atg ggc 403 Thr Glu Leu Arg He Gly Phe Ser Wing Arg Asp Val Val Wing Ala Gly 90 95 100 cgc tac ccg cat cgt ggc cgc tcc gcc gg gag acc gac gca gat cga 451 Arg Tyr Pro His Arg Gly Arg Phe Wing Val Glu Thr Asp Wing Asp Arg 105 110 115 cgc gcc acc gat gac gcc ctg cgc gcc ate aac gcg etc gac ate gcc 499 Arg Ala Thr Asp Asp Ala Leu Arg Ala He Asn Ala Leu Asp He Ala 120 125 130 gag cag ccc gtc aac gaa tta tcg ggc ggc cag cag cag etc ate drops 547 Glu Gln Pro Val Asn Glu Leu Ser Gly Gln Gln Gln Leu He His 135 140 145 ate ggc cga gcg etc gcc ca gc acc gcc gtc gtg ctt etc gac gag 595 He Gly Arg Ala Leu Ala Gln Asp Thr Ala Val Val Leu Leu Asp Glu 150 155 160 165 ccc gtc tcc gcc ctt gat cta cgg falls ca gtt gaa gtc ctt caa etc 643 10 Pro Val Be Ala Leu Asp Leu Arg His Gln Val Glu Val Leu Gln Leu 170 175 180 ctc cgc gcc cg gct aat tcc ggc acc acc gtg ate gtc gtc ctt cae 691 Leu Arg Ala Arg Ala Asn Ser Gly Thr Thr Val He Val Val Leu His • 185 190 195 gat etc. aac falls gtt gcc cgt tgg tgc gac cat gca gtg ttg atg gcc 739 Asp Leu Asn His Val Wing Arg Trp Cys Asp His Wing Val Leu Met Wing 200 205 210 gac ggc gaa gtt gtc tcc ca ggt gac ate cgc gag gtg etc gaa ect 787 Asp Gly Glu Val Val Ser Gln Gly Asp He Arg Glu Val Leu Glu Pro 215 220 225 gcc here ctg tcc acc gtg tac gga ctg ccc att gcg gtg cgc gat gat 835 15 Wing Thr Leu Ser Thr Val Tyr Gly Leu Pro Wing Val Arg Asp Asp 230 235 240 245 ccc gaa acc age tea ctt cgc gtg ate ccg cat cca aat ccc ttt Pro Glu Thr Ser Ser Leu Arg Val He Pro His Pro Asn Pro Phe 250 255 260 tgattgaaag tttgacttaa aaa 903 < 210 > 392 < 211 > 260 • < 212 > PRT < 213 > Corynebacterium glutamicum 20 < 400 > 392 Met Pro Gln Leu Val Glu He Arg Asp Leu Asn Val Glu Phe Pro Ser 1 5 10 15 Arg His Wing Val Lys Asn Val Ser Phe Ser Wing Pro Wing Gly Lys Val 20 25 30 Thr Wing Leu He Gly Pro Asn Gly Wing Gly Lys Ser Thr Ala Leu Ser 35 40 45 Wing Wing Wing Gly Leu Val Glu Ser Thr Gly Val Val Met Val Gly Gly 50 55 60 Ser Gly Val Ala Ser Lys Ser Ala Lys Ala Arg Ala Arg Leu Leu Ser 65 70 75 80 Leu Val Pro Gln Asn Thr Glu Leu Arg He Gly Phe Ser Wing Arg Asp 25 85 90 95 *** - «- i Val Val Wing Met Gly Arg Tyr Pro His Arg Gly Arg Phe Wing Val Glu 100 105 110 Thr Asp Wing Asp Arg Arg Wing Thr Asp Asp Wing Leu Arg Wing He Asn 115 120 125 Wing Leu Asp He Wing Glu Gln Pro Val Asn Glu Leu Ser Gly Gly Gln 130 135 140 Gln Gln Leu He His Gly Arg Ala Leu Ala Gln Asp Thr Ala Val 145 150 155 160 Val Leu Leu Asp Glu Pro Val Ser Ala Leu Asp Leu Arg His Gln Val 165 170 175 Glu Val Leu Gln Leu Leu Arg Ala Arg Ala Asn Ser Gly Thr Thr Val 180 185 190 He Val Val Leu His Asp Leu Asn His Val Wing Arg Trp Cys Asp His 195 200 205 Wing Val Leu Met Wing Asp Gly Glu Val Val Ser Gln Gly Asp He Arg 210 215 220 Glu Val Leu Glu Pro Wing Thr Leu Ser Thr Val Tyr Gly Leu Pro He 225 230 235 240 Wing Val Arg Asp Asp Pro Glu Thr Ser Ser Leu Arg Val He Pro His 245 250 255 10 Pro Asn Pro Phe 260 < 210 > 393 • < 211 > 582 < 212 > DNA < 213 > Corynebacterium gl .utamicum < 220 > < 221 > CDS < 222 > (101) .. (559) < 223 > RXN03081 15 < 400 > 393 acggactgcc < oattegcggtg cgcgatgatt 2 ccgaaaccag ctcacttcgc gtgatcccgc 60 atccaaatcc < cttttgattg aaagtttgat; ttaaaaaccc atg aaa aaa tea etc 115 Met Lys Lys Ser Leu 1 5 ate gcc att gtt gcc agt gcg etc gtg tta age ggc tgc acc tet gat 163 He Wing He Val Wing Wing Wing Leu Val Leu Ser Gly Cys Thr Ser Asp 10 15 20 • tet tet gac tet tcc ggc act tcc gga act gtg gaa acc act tcg att 211 Being Ser Asp Being Ser Gly Thr Being Gly Thr Val Glu Thr Thr Being He 25 30 35 20 here ac age gtt gcc gc gct gac ggc gca tcc cca cgc acc gtc here 259 Thr Thr Ser Val Wing Wing Wing Asp Gly Wing Phe Pro Arg Thr Val Thr 40 45 50 etc gac gat tcc tcc ate acc tta gaa tcc aaa cca gag cgc ate gcc 307 Leu Asp Asp Ser Ser He Thr Leu Glu Ser Lys Pro Glu Arg He Wing 55 60 65 gta etc acc cca gag gca gca tcc ttg gtt etc ccc tet here gcc gcc 355 Val Leu Thr Pro Glu Wing Wing Ser Leu Val Leu Pro He Thr Gly Wing 70 75 80 85 gac cgc gtg gtg atg acc gcc gaa atg gac acc gct gac gaa gaa acc 403 Asp Arg Val Val Met Thr Ala Glu Met Asp Thr Wing Asp Glu Glu Thr 90 95 100 25 gca gct ctg gcc tcc ca gtg gaa tac ca gtc aaa aac ggt ggc agg 451 . i i.t.

Ala Ala Leu Ala Be Gln Val Glu Tyr Gln Val Lys Asn Gly Gly Arg 105 110 115 etc gac ccc gaa ca gtt gtc gcc ggc gac cca gat ttg gtg ate gtc 499 Leu Asp Pro Glu Gln Val Val Wing Gly Asp Pro Asp Leu Val He Val 120 125 130 agt gcg cgt ttc gat acc gaa ca ggc acc ate gac att ttg gaa ggc 547 Be Ala Arg Phe Asp Thr Glu Gln Gly Thr He Asp He Leu Glu Gly 135 140 145 etc aac gtc ccg tagttaactt cgattcagac gct 582 • Leu Asn Val Pro 150 < 210 > 394 < 211 > 153 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 394 Met Lys Lys Ser Leu He Wing He Val Wing Being Wing Leu Val Leu Being 1 5 10 15 10 Gly Cys Thr Being Asp Being Being Asp Being Ser Gly Thr Ser Gly Thr Val 20 25 30 Glu Thr Thr Ser He Thr Thr Ser Val Ala Ala Ala Asp Gly Ala Phe 35 40 45 • Pro Arg Thr Val Thr Leu Asp Asp Ser Ser He Thr Leu Glu Ser Lys 50 55 60 Pro Glu Arg He Ala Val Leu Thr Pro Glu Ala Ala Ser Leu Val Leu 65 70 75 80 Pro He Thr Gly Wing Asp Arg Val Val Met Thr Wing Glu Met Asp Thr 85 90 95 Wing Asp Glu Glu Thr Wing Wing Leu Wing Being Gln Val Glu Tyr Gln Val 100 105 110 15 Lys Asn Gly Gly Arg Leu Asp Pro Glu Gln Val Val Wing Gly Asp Pro 115 120 125 Asp Leu Val He Val Ser Wing Arg Phe Asp Thr Glu Gln Gly Thr He 130 135 140 Asp He Leu Glu Gly Leu Asn Val Pro 145 150 < 210 > 395 < 211 > 444 < 212 > DNA < 213 > Corynebacterium glutamicum 20 < 220 > < 221 > CDS < 222 > (101) .. (4211 < 223 > RXN03082 < 400 &39; 395 cagaagcaat cgcagaaatc gatgcaaacc geattegaca ttegacaage ctgccacctc 60 ccccactgtg ctcactttga tgcaacgcgg accacgccaa atg gtc atg cca gaa 115 Met Val Met Pro Glu 1 5 tet gcc atg etc acc ggc ctg ate cgc gaa gcc ggc gcc act cca gtg 163 Be Wing Met Leu Thr Gly Leu He Arg Glu Wing Gly Gly Thr Pro Val 25 10 15 20 - - • * • ?? gta gat tet etc ggc gcg gta ggc acc ate act gca gac cca gaa caa 211 Val Asp Ser Leu Gly Wing Val Gly Thr He Thr Wing Asp Pro Glu Gln 25 30 35 gtt gtt gcg atg gca ect gag ate ate ate att cag gac ttc ca ggt 259 Val Val Ala Met Ala Pro Glu He He He He Gln Asp Phe Gln Gly 40 45 50 aaa ggc cga gag aac ttc gct aat ttc etc tcc aac cca gcg cta gcc 307 Lys Gly Arg Glu Asn Phe Wing Asn Phe Leu Ser Asn Pro Wing Leu Wing 55 60 65 aac gtt ccc gcc att gaa aac gac aag att ttc tac gcc gac act gtc 355 Asn Val Pro Wing He Glu Asn Asp Lys He Phe Tyr Wing Asp Thr Val 70 75 80 85 acc act gga gtt act gca ggt acc ate g act ggt ctg cag caa 403 Thr Thr Gly Val Thr Wing Gly Thr Asp He Thr Thr Gly Leu Gln Gln 90 95 100 gtg gca gaa atg ctg age tagttttgag atgttgaaac tag 444 Val Ala Glu Met Leu Ser 105 < 210 > 396 < 211 > 107 < 212 > PRT < 213 > Corynebact: erium glutamicum < 400 > 396 Met Val Met Pro Glu Be Ala Met Leu Thr Gly Leu He Arg Glu Ala 1 5 10 15 Gly Gly Thr Pro Val Val Asp Ser Leu Gly Wing Val Gly Thr He Thr 20 25 30 Wing Asp Pro Glu Val Val Val Wing Ala Pro Pro Glu He He He He 35 40 45 Gln Asp Phe Gln Gly Lys Gly Arg Glu Asn Phe Wing Asn Phe Leu Ser 50 55 60 Asn Pro Wing Leu Wing Asn Val Pro Wing He Glu Asn Asp Lys He Phe 65 70 75 80 Tyr Wing Asp Thr Val Thr Thr Gly Val Thr Wing Gly Thr Asp He Thr 85 90 95 Thr Gly Leu Gln Gln Val Wing Glu Met Leu Ser 100 105 < 210 > 397 < 211 > 1479 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1456) < 223 > RXA02261 < 400 > 397 gaaatctata gaaegatagg taaaaactgg actaggttta tctatagcgg aatagaaaat 60 actccgctcg acagcatcac ttagctgaaa ggcctttaac atg gac ccc tea gat 115 Met Asp Pro As Asp 1 5 cta gcc tgg att etc gca gct ttt gcg ttg gta age ctg atg tcc ccc 163 Leu Wing Trp He Leu Wing Wing Phe Wing Leu Val Being Leu Met Phe Pro 10 15 20 gga ttg tcc ctg etc tac ggc ggc atg ctg ggt ggg ca gt falls gtt ctt 211 Gly Leu Ser Leu Leu Tyr Gly Gly Met Leu Gly Gly Gln His Val Leu 25 30 35 aac acg ttc atg atg gtt atg age tea ctt gga ate ate age ctt gtg 259 Asn Thr Phe Met Met Met Met Ser Ser Leu Gly He Ser Ser Leu Val 40 45 50 tac ate att tat gga cae gga ctt gtc tta gga aac tcc ate ggt ggg 307 Tyr He He Tyr Gly His Gly Leu Val Leu Gly Asn Ser He Gly Gly 55 60 65 tgg gga att ate gga aat ccc ctt gaa tac tcc ggc tcc cgc aac att 355 Trp Gly He He Gly Asn Pro Leu Glu Tyr Phe Gly Phe Arg Asn He 70 75 80 85 atg gaa gat gac ggc acc gga gac etc atg tgg gcc ggc ttc tac att 403 Met Glu Asp Asp Gly Thr Gly Asp Leu Met Trp Wing Gly Phe Tyr He 90 95 100 ctg ttc gct gca ate tea etc gca ctt gtt tea tet ggt gca gcg ggg 451 leu phe wing wing be leu wing leu val be ser wing wing alagly gly 105 110 115 cgc atg cgc ttt gga gcg tgg ctg gtc ttc ggt gtc ctg tgg ttc acc 499 Arg 10 Met Arg Phe Gly Wing Trp Leu Val Phe Gly Val Leu Trp Phe Thr 120 125 130 ttt gtg tac gcg cca ctg gca falls tgg gtt ttc gct ate gat gat ect 547 Phe Val Tyr Ala Pro Leu Ala His Trp Val Phe Ala He Asp Asp Pro • 135 140 145 gag tcc ggc tac gtg ggt ggc tgg atg aaa aat gtg ctt gag ttc falls 595 Glu Ser Gly Tyr Val Gly Gly Trp Met Lys Asn Val Leu Glu Phe His 150 155 160 165 gac ttt gct ggt gga acg gca gtg falls atg aat gcg ggt gcg tet gga 643 Asp Phe Wing Gly Gly Thr Wing Val His Met Asn Wing Gly Wing Ser Gly 170 175 180 etc gcg ctg gca ata gtg ctg gga cgc cgc drops tcc atg gct gtg cgt 691 15 Leu Ala Leu Ala He Val Leu Gly Arg Arg His Ser Met Ala Val Arg 185 190 195 cca falls aac ctt cca ctg att ttg att ggt gca gga ctg ate gtt gcg 739 Pro His Asn Leu Pro Leu He Leu He Gly Wing Gly Leu He Val Wing 200 205 210 ggc tgg ttc gga ttc aat ggt ggt acc gca ggt ggt gcc aac ttc etc 787 Gly Trp Phe Gly Phe Asn Gly Gly Thr Wing Gly Gly Wing Asn Phe Leu 215 220 225 gca age tac gtg gtc gtt a cc tet etc att gct gca gct ggc gga atg 835 • Wing Ser Tyr Val Val Val Thr Ser Leu He Wing Wing Wing Gly Gly Met 230 235 240 245 atg ggc ttc atg etc gtt gaa cgt gtg ttc age gga aaa ccc act ttc 883 20 Met Gly Phe Met Leu Val Glu Arg Val Phe Ser Gly Lys Pro Thr Phe 250 255 260 ttt ggc tcg gca acc ggc here ate gca ggc ctt gtg gct ate acc ccg 931 Phe Gly Ser Ala Thr Gly Thr He Wing Gly Leu Val Wing He Thr Pro 265 270 275 gcc gcg gat gca gtg age ccg etc gga gca tcc gcc gtc gga gcg etc 979 Ala Ala Asp Ala Val Ser Pro Leu Gly Ala Phe Ala Val Gly Ala Leu 280 285 290 ggc gca gtt gtc tcc ttc tgg gca att age tgg aag aag gga falls cga 1027 Gly Ala Val Val Ser Phe Trp Ala He Ser Trp Lys Lys Gly His Arg 295 300 305 gtc gat gat tcc ttc gat gtg ttc gca gtc cae gga atg gcc ggc att 1075 25 Val Asp Asp Ser Phe Asp Val Phe Wing Val His Gly Met Wing Gly He , iA? 310 315 320 325 gca ggt gca ctg ttt gtc atg etc ttt ggc gat cca cta gca cca gcg 1123 Ala Gly Ala Leu Phe Val Met Leu Phe Gly Asp Pro Leu Wing Pro Wing 330 335 340 gga gtt tcc gtc gtc ttc ttc ggt ggc gaa etc tcc ctg tgg agg tgc 1171 Gly Val Ser Gly Val Phe Phe Gly Gly Glu Leu Ser Leu Leu Trp Arg 345 350 355 gaa cca ctg gcc ate ate gtg acc ctt here tac gca ttc ggc gtg acc 1219 Glu Pro Leu Wing He He Val Thr Leu Thr Tyr Wing Phe Gly Val Thr • 360 365 370 tgg ttg att gcc acg ate ttg aac aag ttc atg act ctg cgc ate ate 1267 Trp Leu He Wing Thr He Leu Asn Lys Phe Met Thr Leu Arg He Thr 375 380 385 tcc gaa gcc gaa tat gaa ggc att gac cgc gca gaa cae gca gaa tet 1315 Ser Glu Wing Glu Tyr Glu Gly He Asp Arg Wing Glu His Wing Glu Ser 390 395 400 405 gcc tac drops etc aat tcc aac gga att ggg atg gca acc cgc acc aat 1363 Wing Tyr His Leu Asn Being Asn Gly He Gly Met Wing Thr Arg Thr Asn 410 415 420 ttc gga ect gaa ate ccc gag gaa acc gtg ccc gac gcc gtg cag gtg 1411 10 Phe Gly Pro Glu He Pro Glu Glu Thr Val Pro Asp Wing Val Gln Val 425 430 435 ggc gtc gat aag aa gct gat aga gct gat act aga gcc tea aaa 1456 Gly Val Asp Lys Gln Lys He Wing Asp Thr Arg Lys Wing Lys • 440 445 450 tgaccgcaac ctacaccact gaa 1479 < 210 > 398 < 211 > 452 < 212 > PRT < 213 > Corynebacterium glutamicum 15 < 400 > 398 Met Asp Pro Be Asp Leu Wing Trp He Leu Wing Wing Phe Wing Leu Val 1 5 10 15 Ser Leu Met Phe Pro Gly Leu Ser Leu Leu Tyr Gly Met Leu Gly 20 25 30 Gly Gln His Val Leu Asn Thr Met Met Met Val Met Being Ser Leu Gly 35 40 45 I've Been Leu Val Tyr He He Tyr Gly His Gly Leu Val Leu Gly 50 55 60 • Asn Being He Gly Gly Trp Gly He He Gly Asn Pro Leu Glu Tyr Phe 65 70 75 80 Gly Phe Arg Asn He Met Glu Asp Asp Gly Thr Gly Asp Leu Met Trp 20 85 90 95 Wing Gly Phe Tyr He Leu Phe Wing Wing He Ser Leu Wing Leu Val Ser 100 105 110 Ser Gly Wing Wing Gly Arg Met Arg Phe Gly Wing Trp Leu Val Phe Gly 115 120 125 Val Leu Trp Phe Thr Phe Val Tyr Ala Pro Leu Ala His Trp Val Phe 130 135 140 Ala He Asp Asp Pro Glu Ser Gly Tyr Val Gly Gly Trp Met Lys Asn 145 150 155 160 Val Leu Glu Phe His Asp Phe Wing Gly Gly Thr Wing Val His Met Asn 165 170 175 Wing Gly Wing Ser Gly Leu Wing Leu Wing He Val Leu Gly Arg Arg His 25 180 185 190 &, afe? s "Ser Met Wing Val Arg Pro His Asn Leu Pro Leu He Leu He Gly Wing 195 200 205 Gly Leu He Val Wing Gly Trp Phe Gly Phe Asn Gly Gly Thr Wing Gly 210 215 220 Gly Wing Asn Phe Leu Wing Ser Tyr Val Val Val Thr Ser Leu He Wing 225 230 235 240 Wing Wing Gly Gly Met Met Gly Phe Met Leu Val Glu Arg Val Phe Ser 245 250 255 Gly Lys Pro Thr Phe Phe Gly Ser Wing Thr Gly Thr He Wing Gly Leu 260 265 270 Val Wing He Thr Pro Wing Wing Asp Wing Val Ser Pro Leu Gly Wing Phe 275 280 285 Wing Val Gly Wing Leu Gly Wing Val Val Ser Phe Trp Wing He Ser Trp 290 295 300 Lys Lys Gly His Arg Val Asp Asp Ser Phe Asp Val Phe Wing Val His 305 310 315 320 Gly Met Ala Gly He Ala Gly Ala Leu Phe Val Met Leu Phe Gly Asp 325 330 335 Pro Leu Ala Pro Ala Gly Val Ser Gly Val Phe Phe Gly Gly Glu Leu 340 345 350 Ser Leu Leu Trp Arg Glu Pro Leu Wing He He Val 10 Thr Leu Thr Tyr 355 360 365 Wing Phe Gly Val Thr Trp Leu He Wing Thr He Leu Asn Lys Phe Met 370, 375 380 • Thr Leu Arg He Thr Ser Glu Wing Glu Tyr Glu Gly He A sp Arg Wing 385 390 395 400 Glu His Wing Glu Ser Wing Tyr His Leu Asn Ser Asn Gly He Gly Met 405 410 415 Wing Thr Arg Thr Asn Phe Gly Pro Glu Pro Pro Glu Glu Thr Val Pro 420 425 430 Asp Wing Val Gln Val Gly Val Asp Lys Gln Lys He Wing Asp Thr Arg 435 440 445 15 Lys Wing Ser Lys 450 < 210 > 399 < 211 > 1111 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > • < 221 > CDS < 222 > (101) .. (1111) < 223 > RXA02020 20 < 400 > 399 ttggtcaatc aagegtgaat ccggcttcca tgagccagtt gcccgcctca aagcttgacc 60 cattttcata accagtgcca tgtgggttta cggttgatac atg gct aaa tet aat 115 Met Ala Lys Ser Asn 1 5 gaa ggg ctg gga acc gga ctt cgg acc cgc falls etc here atg atg gga 163 Glu Gly Leu Gly Thr Gly Leu Arg Thr Arg His Leu Thr Met Met Gly 10 15 20 etc ggc tcc gca att ggt gcc gt gt ctg ttc etc ggc acc ggc gtt ggt 211 Leu Gly Ser Wing He Gly Wing Gly Leu Phe Leu Gly Thr Gly Val Gly 25 30 35 25 ate cgc gc gcc ccc gca gtc gcc gcg tac ate gcc gcc gga 259 He Arg Ala Ala Gly Pro Ala Val Leu Leu Ala Tyr He He Ala Gly 40 45 50 gcc ate gtt gtt gtt ctt gtt atg cag atg etc ggc gag atg gct gct gcc 307 Ala He Val Val Leu Val Met Gln Met Leu Gly Glu Met Ala Ala Ala 55 60 65 cgt ccc gcc tcc gga tcg ttt tea cgt tac ggc gag gat gct ttc ggc 355 Arg Pro Wing Ser Gly Ser Phe Ser Arg Tyr Gly Glu Asp Wing Phe Gly 70 75 80 85 fall tgg gct gt tc tcc etc ggt tgg ttg tac tgg ttc atg ctg att 403 • His Trp Wing Gly Phe Ser Leu Gly Trp Leu Tyr Trp Phe Met Leu He 90 95 100 atg gtg atg ggc gcc gaa atg act ggc gct gct gcc ate atg ggt gca 451 Met Val Met Gly Wing Glu Met Thr Gly Wing Wing Wing Met Met Gly Wing 105 110 115 tgg ttc ggc gtc gaa ccg tgg att ect tcg ctt gtc tgc gtg gtc ttc 499 Trp Phe Gly Val Glu Pro Trp He Pro Ser Leu Val Cys Val Val Phe 120 125 130 ttc gct gtg gtg aac etc gtc gcg gtt cgc ggt ttc ggt gaa ttc gag 547 Phe Ala Val Val Asn Leu Val Ala Val Arg Gly Phe Gly Glu Phe Glu 135 140 145 tac 595 10 tgg ttc gca ttc att aag gtc gcg gtg ate ate gctt ttc etc tet tpc tet phe wing phe hey lys val wing het w hee wing phe leu he 150 155 160 165 att ggt att gct ctt att ttc gga tgg ctt ccc gga tcc acc ttt gtt 643 He Gly He Ala Leu He Phe Gly Trp Leu Pro Gly Ser Thr Phe Val 170 175 180 gga acc ate aac ttc ate ggt gat cae gga ttc atg ccc aat ggt att 691 Gly Thr Ser Asn Phe He Gly Asp His Gly Phe Met Pro Asn Gly He 185 190 195 tet ggt gtt gct gct gt tg gcg gtg gct gtt ttt gcc ttt ggt ggc 739 Be Gly Val Ala Ala Gly Leu Leu Ala Val Ala Phe Ala Phe Gly Gly 200 205 210 15 att gaa att gtc acc att gca gct gca gag tcc gat aag cca cgt gaa 787 He Glu He Val Thr He Ala Wing Wing Glu Being Asp Lys Pro Arg Glu 215 220 225 gct att tcc ctg gcg gtg cgt gcc gtg att tgg cgt att tea gtc ttt 835 Ala He Ser Leu Ala Val Arg Ala Val He Trp Arg He Ser Val Phe 230 235 240 245 tac ttg ggc tet gtt ttg gtc ate act ttc etc atg ect tat gag tcg 883 Tyr Leu Gly Ser Val Leu Val He Thr Phe Leu Met Pro Tyr Glu Ser 250 255 260 • ate aat ggt gcc gac acc gct gcg gaa tcc ccc ttc acc ca ate ate ctg 931 He Asn Gly Ala Asp Thr Ala Ala Glu Ser Pro Phe Thr Gln He Leu 265 270 275 20 gcg atg gca aac ate ect ggc acg gtt ggt ttc atg gaa gcg ate ate 979 Wing Met Wing Asn He Pro Gly Thr Val Gly Phe Met Glu Wing He He 280 285 290 gtt cta gca ctg ctt tcc gct ttc aac gcc ca a ate tat gcc act tet 1027 Val Leu Ala Leu Leu Ser Ala Phe Asn Ala Gln He Tyr Ala Thr Ser 295 300 305 cgt ttg gta ttt tcc atg gcg aat cga caa gac gct ccg cga gtt ttc 1075 Arg Leu Val Phe Ser Met Wing Asn Arg Gln Asp Wing Pro Arg Val Phe 310 315 320 325 agt aag etc age acc age falls gtc ccc acc aat gcg 1111 Ser Lys Leu Ser Thr Ser His Val Pro Thr Asn Ala 330 335 25 < 210 > 400 < 211 > 337 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 400 Met Ala Lys Ser Asn Glu Gly Leu Gly Thr Gly Leu Arg Thr Arg His 1 5 10 15 • 5 Leu Thr Met Met Gly Leu Gly Be Wing He Gly Wing Gly Leu Phe Leu 20 25 30 Gly Thr Gly Val Gly He Arg Wing Wing Gly Pro Wing Val Leu Leu Wing 35 40 45 Tyr He He Wing Wing Gly Wing Val Val Leu Val Met Gln Met Leu Gly 50 55 60 Glu Met Wing Wing Wing Arg Pro Wing Ser Gly Ser Phe Ser Arg Tyr Gly 65 70 75 80 Glu Asp Wing Phe Gly His Trp Wing Gly Phe Ser Leu Gly Trp Leu Tyr 85 90 95 Trp Phe Met Leu He Met Val Met Gly Wing Glu Met Thr Gly Ala Wing 100 105 110 10 Wing He Met Gly Wing Trp Phe Gly Val Glu Pro Trp He Pro Ser Leu 115 120 125 Val Cys Val Val Phe Phe Val Val Asn Leu Val Val Val Arg Gly 130 135 140 • Phe Gly Glu Phe Glu Tyr Trp Phe Wing Phe He Lys Val Wing Val He 145 150 155 160 He Wing Phe Leu He He Gly Wing He Wing Lehe He Phe Gly Trp Leu Pro 165 170 175 Gly Being Thr Phe Val Gly Thr Ser Asn Phe He Gly Asp His Gly Phe 180 185 190 Met Pro Asn Gly He Ser Gly Val Wing Wing Gly Leu Leu Ala Ala Ala 195 200 205 15 Phe Ala Phe Gly Gly He Glu He Val Thr He Ala Ala Ala Glu Ser 210 215 220 Asp Lys Pro Arg Glu Ala He Ser Leu Ala Val Arg Ala Val He Trp 225 230 235 240 Arg He Ser Val Phe Tyr Leu Gly Ser Val Leu Val He Thr Phe Leu 245 250 255 Met Pro Tyr Glu Ser He Asn Gly Wing Asp Thr Wing Ala Glu Ser Pro 260 265 270 Phe Thr Gln He Leu Ala Met Wing Asn He Pro Gly Thr Val Gly Phe 275 280 285 Met Glu Wing He He Val Leu Ala Leu Leu Ser Wing Phe Asn Wing Gln 290 295 300 20 He Tyr Wing Thr Ser Arg Leu Val Phe Ser Met Wing Asn Arg Gln Asp 305 310 315 320 Wing Pro Arg Val Phe Ser Lys Leu Ser Thr Ser His Val Pro Thr Asn 325 330 335 Wing < 210 > 401 < 211 > 784 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > 25 < 221 > CDS < 222 > (101) .. (l í <223> RXA00281 <400> 401 ggttgactct -ttggetttga tigceaigcatt cgiccaaagcg tggiccctctt 'taagaaagct 60 actgaacaca, acag; agta, gg tttatigcgai z actggtgcgc atg ate aac gtt gaa 115 Met He Asn Val Glu 1 5 ggc etc acc aaa ca g tat ggt cag gtc cgc gca gtc gat gat ctg age 163 Gly Leu Thr Lys Gln Tyr Gly Gln Val Arg Wing Val Asp Asp Leu Ser 10 15 20 ttc gaa gta aaa ccc gga ata gtc acc gga ttt etc ggc ccc aac ggc 211 Phe Glu Val Lys Pro Gly He Val Thr Gly Phe Leu Gly Pro Asn Gly 25 30 35 gcc gga aaa tcc acc acg atg cgg ctg ate ctt ggc tta gat aat cca 259 Wing Gly Lys Ser Thr Thr Met Arg Leu He Leu Gly Leu Asp Asn Pro 40 45 50 act gca ggg cat gcc acg ate gaa gga caca ccc tac cga tcg etc aaa 307 Thr Ala Gly His Wing Thr He Glu Gly Gln Pro Tyr Arg Ser Leu Lys 55 60 65 aat ccc ctg acc aaa gtg gga gca ctg ctt gat gcc aaa gca here falls 355 Asn Pro Leu Thr Lys Val Gly Ala Leu Leu Asp Ala Lys Ala Thr His 70 75 80 85 cca aat aga aac gca gaa aac falls etc aag tgg ate gcc cgt gca aat 403 Pro Asn Arg Thr Wing Glu Asn His Leu Lys Trp He Wing Arg Wing Asn 90 95 100 ggg ctg tcc acc aaa aga gtc gat gaa gtt etc acc etc gtg gga ctg 451 Gly Leu Ser Thr Lys Arg Val Asp Glu Val Leu Thr Leu Val Gly Leu 105 110 115 act ggt gtt ggg tea aag aag ggt ggg ttt tea cta ggc atg ggc 499 Thr Gly Val Gly Ser Lys Lys Thr Gly Gly Phe Ser Leu Gly Met Gly 120 125 130 cag cgt cta gga ctt gct gca gca ttg etc ggc gat ccg gaa tac tta 547 Gln Arg Leu Gly Leu Ala Ala Ala Leu Leu Gly Asp Pro Glu Tyr Leu 135 140 145 att etc gac gaa ccc gtc aac ggc ctt gac cca gaa ggc att falls tgg 595 He Leu Asp Glu Pro Val Asn Gly Leu Asp Pro Glu Gly He His Trp 150 155 160 165 gtg cgc acc ttg ca g aac gcc aag cag ggc aga acc gtg etc 643 Val Arg Thr Leu Leu Gln Asn He Wing Lys Gln Gly Arg Thr Val Leu 170 175 180 gtg agt tcc falls ctg ctg tcc gag atg gcg caa act gcg gaa cat ttg 691 Val Ser Ser His Leu Leu Ser Glu Met Wing Gln Thr Wing Glu His Leu 185 190 195 ate gtg att ggg cgt ggc aag ctg gtc gcc gat atg ccc atg cat gag 739 He Val He Gly Arg Gly Lys Leu Val Wing Asp Met Pro Met His Glu 200 205 210 ttt gtg cgc tcc cat tcc gct tcc here gtt gtg gtg cgg gca gca 784 Phe Val Arg Ser His Ser Ala Ser Thr Val Val Val Arg Ala Ala 215 220 225 < 210 > 402 < 211 > 228 < 212 > PRT < 213 > Cc > rynebact: erium glutamicum < 400 > 402 Met He Asn Val Glu Gly Leu Thr Lys Gln Tyr Gly Gln Val Arg Ala 1 5 10 15 Val Asp Asp Leu Ser Phe Glu Val Lys Pro Gly He Val Thr Gly Phe 20 25 30 Leu Gly Pro Asn Gly Wing Gly Lys Ser Thr Thr Met Arg Leu He Leu 35 40 45 Gly Leu Asp Asn Pro Thr Wing Gly His Wing Thr He Glu Gly Gln Pro 50 55 60 Tyr Arg Ser Leu Lys Asn Pro Leu Thr Lys Val Gly Ala Leu Leu Asp • 65 70 75 80 Ala Lys Ala Thr His Pro Asn Arg Thr Ala Glu Asn His Leu Lys Trp 85 90 95 He Ala Arg Ala Asn Gly Leu Ser Thr Lys Arg Val Asp Glu Val Leu 100 105 110 Thr Leu Val Gly Leu Thr Gly Val Gly Ser Lys Lys Thr Gly Gly Phe 115 120 125 Ser Leu Gly Met Gly Gln Arg Leu Gly Leu Ala Ala Ala Leu Leu Gly 130 135 140 Asp Pro Glu Tyr Leu He Leu Asp Glu Pro Val Asn Gly Leu Asp Pro 145 150 155 160 10 Glu Gly He His Trp Val Arg Thr Leu Leu Gln Asn He Wing Lys Gln 165 170 175 Gly Arg Thr Val Leu Val Ser Ser His Leu Leu Ser Glu Met Wing Gln 180 185 190 • Thr Ala Glu His Leu He Val He Gly Arg Gly Lys Leu Val Wing Asp 195 200 205 Met Pro Met His Glu Phe Val Arg Ser His Ser Wing Ser Thr Val Val 210 215 220 Val Arg Ala Ala 225 < 210 > 403 15 < 211 > 852 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (852) < 223 > RXN00570 < 400 > 403 acg aga ect cgg ccc caa gaa att ggc aac ggg ctt gtc gca ctg att 48 Thr Arg Pro Arg Pro Gln Glu He Gly Asn Gly Leu Val Ala Leu He 20 1 5 10 15 ttc tcc gca tcc gga ccc ate gca gtg ate ctg gct gct gct gca gcg 96 Phe Ser Ala Ser Gly Pro He Ala Val He Leu Ala Ala Ala Ala Ala 20 25 30 gga aac ctt tcg ect gat caá here tet tea tgg ate ttc gga gca ttt 144 Gly Asn Leu Ser Pro Asp Gln Thr Ser Ser Trp He Phe Gly Wing Phe 35 40 45 tta ggc aac gga ctg etc acg ctg tgg ctt acc tat atg tac cgc age 192 Leu Gly Asn Gly Leu Leu Thr Leu Trp Leu Thr Tyr Met Tyr Arg Ser 50 55 60 ccg cag gca tac ttc tgg acg att ccc gga acc gtc ate gtg ggc gac 240 Pro Gln Ala Tyr Phe Trp Thr He Pro Gly Thr Val He Val Gly Asp 25 65 70 75 80 ? rA ?? tea ctt acc falls tta agt ttc gct gaa gtt ate ggc gca tac ctt gtt 288 Be Leu Thr His Leu Be Phe Wing Glu Val He Gly Wing Tyr Leu Val 85 90 95 ggc gtt gtg gtt ttt gtg etc gga ggg tgg acc ggt etc gga ggg cgg 336 Thr Gly Val Val Val Phe Ala Leu Gly Trp Thr Gly Leu He Gly Arg 100 105 110 ate atg gcg gta ctg cca cca acc ate gtg atg gcc atg gtc gca ggc 384 He Met Ala Wing Val Leu Pro Pro Thr He Val Met Wing Met Val Wing Gly 115 120 125 att ttc etc cgc ttc gga etc gac etc ate gac gcc age gtg acc gac 432 He Phe Leu Arg Phe Gly Leu Asp Leu He Asp Ala Ser Val Thr Asp 130 135 140 ccg etc att gca ctt ccc atg gtc ata gtt ttt gtg gca ttg age atg 480 Pro Leu He Ala Leu Pro Met Val He Val Val Phe Ala Leu Ser Met 145 150 155 160 agt ccc cgc ttg gca age ate gcc cca ccc gtt gca gta gcc gca gta 528 Ser Pro Arg Leu Wing Ser Wing Pro Pro Val Wing Val Wing Wing Val 165 170 175 gtg gga gt acc ate gtt gcc ate gca ccc ggc aaa cta gcg ccc gga att 576 Val Gly Thr He Val Wing He Wing Ser Gly Lys Leu Wing Ser Gly He 180 185 190 cta gac aac gga att ate tcc cgc ccc gtc ttt acc gcc cca gaa ttt 624 Leu Asp Asn Gly He He Ser Arg Pro Val Phe Thr Ala Pro Glu Phe 195 200 205 tcc tcc gcc gcc ate atg gaa etc gtt gtt ccc ttg gcg ate acc gta 672 Being Phe Wing Wing He Met Glu Leu Val Val Pro Leu Wing He Thr Val 210 215 220 gtc att gtc caa aac ggc ca ggc gtc gca gtg ctt aaa gca gca ggt 720 Val He Val Gln Asn Gly Gln Gly Val Ala Val Leu Lys Ala Wing Gly 225 230 235 240 falls cgc ccc gga gta aac ctt gcc gcc gcg gcc tcc gga ctg tgg tcc 768 His Arg Pro Gly Val Asn Leu Wing Wing Wing Wing Ser Gly Leu Trp Ser 245 250 255 cta ccc atg gcg ttg ate ggc aac ate acc acc acctgc etc acc ggc ccc 816 Leu Pro Met Ala Leu He Gly Asn He Thr Thr Cys Leu Thr Gly Pro 260 265 270 acc aac gcg ctg ate gtc gcc gga gca aaa tea falls 852 Thr Asn Ala Leu He Val Ala Gly Ala Lys Ser His 275 280 < 210 > 404 < 211 > 284 < 212 > PRT < 213 > Corynebact, erium glutamicum < 400 > 404 Thr Arg Pro Arg Pro Gln Glu He Gly Asn Gly Leu Val Ala Leu He 1 5 10 15 Phe Be Wing Ser Gly Pro He Wing Val He Leu Wing Wing Wing Wing 20 25 30 Gly Asn Leu Ser Pro Asp Gln Thr Ser Ser Trp He Phe Gly Wing Phe 35 40 45 Leu Gly Asn Gly Leu Leu Thr Leu Trp Leu Thr Tyr Met Tyr Arg Ser 50 55 60 Pro Gln Wing Tyr Phe Trp Thr He Pro Gly Thr Val He Val Gly Asp 65 70 75 80 Being Leu Thr His Leu Being Phe Wing Glu Val He Gly Wing Tyr Leu Val 85 90 95 Thr Gly Val Val Val Phe Ala Leu Gly Trp Thr Gly Leu He Gly Arg 100 105 110 He Met Wing Val Leu Pro Pro Thr He Val Met Wing Met Val Wing Gly 115 120 125 He Phe Leu Arg Phe Gly Leu Asp Leu He Asp Wing Ser Val Thr Asp 130 135 140 Pro Leu He Wing Leu Pro Met Val He Val Phe Val Wing Leu Ser Met 145 150 155 160 Ser Pro Arg Leu Wing Be Wing Pro Wing Val Wing Val Wing Wing Val 165 170 175 Val Gly Thr He Val Wing Wing Wing Ser Gly Lys Wing Wing Ser Gly He 180 185 190 Leu Asp Asn Gly He He Ser Arg Pro Val Phe Thr Ala Pro Glu Phe 195 200 205 Ser Phe Wing Wing He Met Glu Leu Val Val Pro Leu Wing He Thr Val 210 215 220 Val He Val Gln Asn Gly Gln Gly Val Wing Val Leu Lys Wing Wing Gly 225 230 235 240 His Arg Pro Gly Val Asn Leu Wing Ala Ala Ala Ser Gly Leu Trp Ser 245 250 255 10 Leu Pro Met Ala Leu He Gly Asn He Thr Thr Cys Leu Thr Gly Pro 260 265 270 Thr Asn Ala Leu He Val Ala Gly Ala Lys Ser His • 275 280 < 210 > 405 < 211 > 498 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > 15 < 221 > CDS < 222 > (1) .. (498) < 223 > FRXA00570 < 400 > 405 cca acc ate gtg atg gcc atg gtc gca ggc att ttc etc cgc ttc gga 48 Pro Thr He Val Met Wing Met Val Wing Gly He Phe Leu Arg Phe Gly 1 5 10 15 etc gac etc ate gac gcc age gtg acc gac ccg etc att gca ctt ccc 96 • Leu Asp Leu He Asp Wing Ser Val Thr Asp Pro Leu He Wing Leu Pro 20 • 25 30 atg gtc ata gtt ttt gtg gca ttg age atg agt ccc cgc ttg gca age 144 20 Met Val He Val Phe Val Ala Leu Ser Met Ser Pro Arg Leu Wing Ser 35 40 45 ate gcc cca ccc gtt gca gta gcc gca gta gtg gga acc ate gtt gcc 192 He Ala Pro Pro Val Ala Val Ala Ala Val Val Gly Thr He Val Ala 50 55 60 ate gca tcc ggc aaa cta gcg tcc gga att cta gac aac gga att ate 240 He Wing Wing Gly Lys Leu Wing Ser Gly He Leu Asp Asn Gly He He 65 70 75 80 tcc cgc ccc gtc ttt acc gcc cca gaa ttt ttcccc ttttcc ggcccc ggcccc aattee aattgg 288 Ser Arg Pro Val Phe Thr Wing Pro Glu Phe Ser Phe Ala Wing Met 85 90 95 gaa etc gtt gtt ccc ttg gcg ate acc gta ggttcc aatttt ggttcc ccaaáa aaaacc ggggcc 336 25 Glu Leu Val Val Pro Leu Ala He Thr Val Val He Val Gln Asn Gly tamtfttilliitoftiaaqri g -, -? .¿ ^^ 100 105 110 caá ggc gtc gca gtg ctt aaa gca gca ggt falls cgc ccc gga gta aac 384 Gln Gly Val Wing Val Leu Lys Wing Wing Gly His Arg Pro Gly Val Asn 115 120 125 ctt gcc gcc gcg gcc tcc gga ctg tgg tcc cta ccc atg gcg ttg ate 432 Leu Ala Ala Ala Ala Ser Gly Leu Trp Ser Leu Pro Met Ala Leu He 130 135 140 ggc aac acc acc acctgc etc acc ggc ccc ac aac gcg ctg ate gtc 480 Gly Asn He Thr Thr Cys Leu Thr Gly Pro Thr Asn Ala Leu He Val 145 150 155 160 gcc gga gca aaa tea drops 498 Ala Gly Ala Lys Ser His 165 < 210 > 406 < 211 > 166 '< 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 406 Pro Thr He Val Met Wing Met Val Wing Gly He Phe Leu Arg Phe Gly 1 5 10 15 Leu Asp Leu He Asp Wing Ser Val Thr Asp Pro Leu He Wing Leu Pro 20 25 30 Met Val He Val Phe Val Wing Leu Ser Met Ser Pro Arg Leu Wing Ser 35 40 45 He Wing Pro Pro Val Wing Val Wing Wing Val Val Gly Thr He Val Wing 50 55 60 Wing Wing Ser Gly Lys Leu Wing Ser Gly He Leu Asp Asn Gly He He 65 70 75 80 Ser Arg Pro Val Phe Thr Wing Pro Glu Phe Ser Phe Wing Wing He Met 85 90 95 Glu Leu Val Val Pro Leu Wing He Thr Val Val He Val Gln Asn Gly 100 105 110 Gln Gly Val Wing Val Leu Lys Wing Wing Gly His Arg Pro Gly Val Asn 115 120 125 Leu Ala Ala Ala Ala Ser Gly Leu Trp Ser Leu Pro Met Ala Leu He 130 135 140 Gly Asn He Thr Thr Cys Leu Thr Gly Pro Thr Asn Ala Leu He Val 145 150 155 160 Ala Gly Ala Lys Ser His 165 < 210 > 407 < 211 > 1280 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (1257) < 223 > RXN00571 < 400 > 407 here ctt gtt cca cag gtt tac gaa ata gtg ate tac ggc gct gtg ctg 48 Thr Leu Val Pro Gln Val Tyr Glu He Val He Tyr Gly Ala Val Leu 1 5 10 15 • Mui tea gct gta cat gaa gat cca acc ggt gcg gcg etc age cca gca 96 Ser Ala Val His Glu Asp Pro Thr Gln He Gly Ala Leu Ser Pro Wing 20 25 30 gtc gcc gcc gcc ccc gcc tcc tac gcc atg ate ggc gtg atg ate ggt 144 Val Ala Gly Thr Leu Gly Ser Tyr Ala Met He Gly Val Met He Gly 35 40 45 gct cta tet gca ggt gcc gtt ggt gac cgc ctt ggt cgt cgc aaa gtt 192 Ala Leu Be Wing Gly Wing Val Gly Asp Arg Leu Gly Arg Arg Lys Val 50 55 60 • atg etc acc gca ate gtc tgg ttc tet gtg ggc atg gcg ctg acc gcg 240 Met Leu Thr Ala He Val Trp Phe Ser Val Gly Met Ala Leu Thr Ala 65 70 75 80 ttc gcg tcc tcg att gcg ctg ttc ggt ttc ttg cgc ttc etc acc gga 288 Phe Wing Being Ser Wing Leu Phe Gly Phe Leu Arg Phe Leu Thr Gly 85 90 95 ctt ggc gtg ggc atg ate gtt gca acc ggc ggc gca ate ate gcg gag 336 Leu Gly Val Gly Met He Val Wing Thr Gly Gly Wing He He Wing Glu 100 105 110 ttc gct cca gcg aat agg cgc aac ttg ttc aac gca ate gtg tac tcc 384 Phe Wing Pro Wing Asn Arg Arg Asn Leu Phe Asn Wing He Val Tyr Ser 115 120 125 10 ggt gtc cc gcc ggt ggc gtg ctg gct tet ate ctt gca ctg etc ttt 432 Gly Val Pro Wing Gly Gly Val Leu Wing Being He Leu Wing Leu Leu Phe 130 135 140 • gaa gat gtc ate ggc tgg cgc gga etc ttc etc ate ggt gga tcc cca 480 Glu Asp Val He Gly Trp Arg Gly Leu Phe Leu He Gly Gly Ser Pro 145 150 155 160 ctg ctg ctg etc ctg cca ctt gca tac ttc ctc etc cca gag tcc ccg 528 Leu Leu Phe Leu Leu Pro Leu Wing Tyr Phe Phe Leu Pro Glu Pro Pro 165 170 175 cgc tgg etc acc tcc cgc ggc cgt gct gcg gac gcc aaa gcc etc tgc 576 Arg Trp Leu Thr Ser Arg Gly Arg Wing Wing Asp Wing Lys Wing Leu Cys 180 185 190 15 gca cgc tat ggg ctg ccg acg gag gaa ttt gtc gtc gaa aag cag cag 624 Wing Arg Tyr Gly Leu Pro Thr Glu Glu Phe Val Val Glu Lys Gln Gln 195 200 205 gaa here aag ggc acc gga ttc gct gga att ttc tcc tcc aag tac etc 672 Glu Thr Lys Gly Thr Gly Phe Wing Gly He Phe Ser Ser Lys Tyr Leu 210 215 220 atg ggc acc att etc ate ggc gca atg age ttc ate gggggg ccttgg cctttt ttccgg 720 Met Gly Thr He Leu He Gly Wing Met Being Phe He G Gllyy L Leeuu L Leeuu S Seerr 225 230 235 224400 acc tac ggc ctg aac acc tgg ttg cca aag ate atg ggaaaa ttcccc aaaacc ggggcc 768 Thr Tyr Gly Leu Asn Thr Trp Leu Pro Lys He Met G Gulluu S Seerr A Assnn G Gllyy 20 245 250 225555 gca acc tea cat gat tcc ctg tac tcc ctg ctg ttc etc aac ggc ggc 816 Wing Thr Ser His Asp Ser Leu Tyr Ser Leu Leu Phe Leu Asn Gly Gly 260 265 270 gca gtg ttc ggt ggc etc ate gca tcc tgg ttc gct gac cgc aattee ggggcc 864 Wing Val Phe Gly Gly Leu He Wing Ser Trp Phe Wing Asp Arg H Hee G Gllyy 275 280 285 gcg aag acc gtg ate acc tcc acc ttc gct etc gcc gcg ate ttggcc eettcc 912 Wing Lys Thr Val He Thr Ser Thr Phe Wing Leu Wing Wing C Cyyss L Leeuu 290 295 300 gga gtc ctg cca aac ate tcc tgg tgg cca atg atg tac acc ggccaa aattee 960 Gly Val Leu Pro Asn He Ser Ser Trp Pro Met Met Tyr Thr A Allaa H Hee 25 305 310 315 3 32200 gca ttc gca ggc gtc ggc gtc ctg ggc acc ggc cag gtt etc acc tac ggc 100E Wing Phe Wing Gly Val Gly Val Leu Gly Thr Gln Val Leu Thr Tyr Gly 325 330 335 ctg acc tcg aac ttc ttc gga acc gaa tgc cgc gca gcg gga gtt gca 1056 Leu Thr Ser Asn Phe Phe Gly Thr Glu Cys Arg Ala Wing Gly Val Wing 340 345 350 tgg tgt gca gga ttc ggc cga etc ggc gga ate gtc gga cca gca ate 1104 Trp Cys Wing Gly Phe Gly Arg Leu Gly Gly He Val Gly Pro Wing 355 360 365 • ggt ggc ctg ate ate ggc gca gga ttc gga cca age tcc gca ttc etc 1152 GY and Gly Leu He He Gly Wing Gly Wing Phe Gly Pro Ser Wing Wing Phe Leu 370 375 380 ate ttc gca gca gct gcc gca gca gcc gcg gtc tgc acc ttg ctg ate 1200 He Phe Ala Ala Ala Ala Ala He Gly Ala Val Cys Thr Leu Leu He 385 390 395 400 ccg cgc tcc cca gca gaa gta gag gtc aag gtc gcg cag gaa cca ctt 1248 Pro Arg Ser Pro Wing Glu Val Glu Val Lys Val Wing Gln Glu Pro Leu 405 410 415 gca cgt gtc taacc ccaat taattcgaaa ca. 1280 Ala Arg Val 10 < 210 > 408 < 211 > 419 < 212 > PRT < 213 > Corynebacterium glutamicum < 40? 0 > 408 Thr Leu Val Pro Gln Val Tyr Glu He Val He Tyr Gly Ala Val Leu 1 5 10 15 Ser Ala Val His Glu Asp Pro Thr Gln He Gly Ala Leu Ser Pro Wing 20 25 30 15 Val Wing Gly Tnr Leu Gly Ser Tyr Ala Met He Gly Val Met He Gly 35 40 45 Ala Leu Ser Ala Gly Ala Val Gly Asp Arg Leu Gly Arg Arg Lys Val 50 55 60 Met Leu Thr Ala He Val Trp Phe Ser Val Gly Met Ala Leu Thr Ala 65 70 75 80 Phe Wing Being Be Wing Wing Leu Phe Gly Phe Leu Arg Phe Leu Thr Gly 85 90 95 Leu Gly Val Gly Met He Val Wing Thr Gly Wing Ala He He Wing Glu • 100 105 110 Phe Wing Pro Wing Asn Arg Arn Asn Leu Phe Asn Wing He Val Tyr Ser 115 120 125 20 Gly Val Pro Wing Gly Gly Val Leu Wing Being He Leu Wing Leu Leu Phe 130 135 140 Glu Asp Val He Gly Trp Arg Gly Leu Phe Leu He Gly Gly Ser Pro 145 150 155 160 Leu Leu Phe Leu Leu Pro Leu Wing Tyr Phe Phe Leu Pro Glu Pro Pro 165 170 175 Arg Trp Leu Thr Ser Arg Gly Arg Wing Wing Asp Wing Lys Wing Leu Cys 180 185 190 Wing Arg Tyr Gly Leu Pro Thr Glu Glu Phe Val Val Glu Lys Gln Gln 195 200 205 Glu Thr Lys Gly Thr Gly Phe Wing Gly He Phe Ser Ser Lys Tyr Leu 210 215 220 25 Met Gly Thr He Leu He Gly Wing Met Ser Phe He Gly Leu Leu Ser . ^. ^ taa? a. 225 230 235 240 Thr Tyr Gly Leu Asn Thr Trp Leu Pro Lys He Met Glu Ser Asn Gly 245 250 255 Wing Thr Ser His Asp Ser Leu Tyr Ser Leu Leu Phe Leu Asn Gly Gly 260 265 270 Wing Val Phe Gly Gly Leu He Wing Being Trp Phe Wing Asp Arg He Gly 275 280 285 Wing Lys Thr Val He Thr Ser Thr Phe Wing Leu Wing Wing He Cys Leu • 290 295 300 Gly Val Leu Pro Asn He Being Ser Trp Pro Met Met Tyr Thr Wing He 305 310 315 320 Wing Phe Wing Gly Val Gly Val Leu Gly Thr Gln Val Leu Thr Tyr Gly 325 330 335 Leu Thr Ser Asn Phe Phe Gly Thr Glu Cys Arg Ala Wing Gly Val Wing 340 345 350 Trp Cys Wing Gly Phe Gly Arg Leu Gly Gly He Val Gly Pro Wing He 355 360 365 Gly Gly Leu He He Gly Wing Gly Phe Gly Pro Ser Being Wing Phe Leu 370 375 380 He Phe Wing Wing Wing Wing Wing He Gly Wing Val Cys Thr Leu Leu He 10 385 390 395 400 Pro Arg Ser Pro Ala Glu Val Glu Val Lys Val Ala Gln Glu Pro Leu 405 410 415 Ala Arg Val • < 210 > 409 < 211 > 1208 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS 15 < 222 > (1) .. (1185) < 223 > FRXA00571 < 400 > 409 cag ate ggt gcg etc age cca gca gtc gcc gcc acc ctt ggt tcc tac 48 Gln He Gly Wing Leu Ser Pro Wing Val Wing Gly Thr Leu Gly Ser Tyr 1 5 10 15 gcc atg ate ggc gtg atg ate ggt gct cta tet gca ggt gcc gtt ggt 96 Wing Met Wing Val Gly • He Gly Val Met He Gly Wing Leu Ser Wing Gly 20 25 30 gac cgc ctt ggt cgt cgc aaa gtt atg etc acc gca ate gtc tgg ttc 144 Asp Arg Leu Gly Arg Arg Lys Val Met Leu Thr Ala He Val Trp Phe 20 35 40 45 tet gtg ggc atg gcg ctg acc gcg ttc gcg tcc tcg att gcg ctg ttc 192 Ser Val Gly Met Wing Leu Thr Wing Phe Wing Being Ser Wing Wing Leu Phe 50 55 60 ggt ttc ttg cgc ttc etc acc gga ctt ggc gtg ggc atg ate gtt gca 240 Gly Phe Leu Arg Phe Leu Thr Gly Leu Gly Val Gly Met He Val Wing 65 70 75 80 acc ggc ggc gca ate ate gcg gag tcc gct cca gcg aat agg cgc aac 288 Thr Gly Gly Wing He Wing Wing Glu Phe Wing Pro Wing Asn Arg Arg Asn 85 90 95 ttg ttc aac gca ate gtg tac tcc ggt gtc cca gcc ggt ggc gtg ctg 336 Leu Phe Asn Wing He Val Tyr Ser Gly Val Pro Wing Gly Gly Val Leu 25 100 105 110 i-l ¿? .A.?.? gct tet ate ctt gca ctg etc ttt gaa gat gtc ate ggc tgg cgc gga 384 Wing Be He Leu Wing Leu Leu Phe Glu Asp Val He Gly Trp Arg Gly 115 120 125 etc ttc etc ate ggt gga tcc cca cta ctc ttc etc ctg cca ctt gca 432 Leu Phe Leu He Gly Gly Pro Pro Leu Leu Phe Leu Leu Pro Leu Wing 130 135 140 tac ttc tcc etc cca gac tcc ccg cgc tgg etc acc tcc cgc ggc cgt 480 Tyr Phe Phe Leu Pro Glu Ser Pro Arg Trp Leu Thr Ser Arg Gly Arg 145 150 155 160 gct gcg gac gcc aaa gcc etc tgc gca cgc tat ggg ctg cgc acg gag 528 Wing Wing Asp Wing Lys Wing Leu Cys Wing Arg Tyr Gly Leu Pro Thr Glu 165 170 175 gaa ttt gtc gtc gaa aag cag cag gaa here aag ggc acc gga ttc gct 576 Glu Phe Val Val Glu Lys Gln Gln Glu Thr Lys Gly Thr Gly Phe Wing 180 185 190 gga att ttc tcc tcc aag tac etc atg ggc acc att etc ate ggc gca 624 Gly He Phe Be Ser Lys Tyr Leu Met Gly Thr He Leu He Gly Wing 195 200 205 atg age ttc ate ggg ctg ctt tcg acc tac ggc ctg aac acc tgg ttg 672 Met Ser Phe He Gly Leu Leu Ser Thr Tyr Gly Leu Asn Thr Trp Leu 10 210 215 220 cca aag ate atg gaa tcc aac ggc gca acc cat cat tct ctg tac 720 Pro Lys He Met Glu Ser Asn Gly Ala Thr Ser His Asp Ser Leu Tyr 225 230 235 240 • tcc ctg ctg ttc etc aac ggc ggc gca gtg ttc ggt ggc etc ate gca 768 Ser Leu Leu Phe Leu Asn Gly Gly Wing Val Phe Gly Gly Leu He Wing 245 250 255 tcc tgg ttc gct gac cgc ate ggc gcg aag acc gtg ate acc tcc acc 816 Ser Trp Phe Wing Asp Arg He Gly Wing Lys Thr Val He Thr Ser Thr 260 265 270 ttc gct etc gcc gcg ate tgc etc gga gtc ctg cca aac ate tcc tcc 864 Phe Ala Leu Ala Wing Cys Leu Gly Val Leu Pro Asn He Ser Ser 15 275 280 285 tgg cca atg atc tac acc gca ate gca tcc gca ggc gtc gcc gtc ctg 912 trp pro Met Met Tyr Thr Ala He Wing Phe Wing Gly Val Gly Val Leu 290 295 300 ggc acc ggc cag etc acc tac ggc ctg acc tcg aac ttc ttc gga acc 960 Gly Thr Gln Val Leu Thr Tyr Gly Leu Thr Ser Asn Phe Phe Gly Thr 305 310 315 320 gaa tgc cgc gca gcg gga gtt gca tgg tgt gca gga ttc ggc cga etc 1008 Glu Cys Arg Wing Wing Gly Val Wing Trp Cys Wing Gly Phe Gly Arg Leu • 325 330 335 ggc gga ate gtc gga gca cca gca ate ggt ggc ctg ate ate ggc gca gga 1056 Gly Gly He Val Gly Pro Wing He Gly Gly Leu He He Gly Wing Gly 20 340 345 350 ttc gga cca age tcc gca ttc etc ttc gt gca gca gcc gcc gca ate 1104 Phe Gly Pro Ser Wing Phe Leu He Phe Wing Wing Wing Ala Ala He 355 360 365 ggc gcg gtc tgc acc ttg ctg ate ccg cgc tcc cca gca gaa gta gag 1152 Gly Wing Val Cys Thr Leu Leu He Pro Arg Ser Pro Wing Glu Val Glu 370 375 380 gtc aag gtc gcg cag gaa cca ctt gca cgt gtc taaccccaat taattcgac 1205 Val Lys Val Ala Gln Glu Pro Leu Ala Arg Val 385 390 395 ca 1208 25 < 210 > 410 < 211 > 395 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 410 Gln He Gly Ala Leu Ser Pro Ala Ala Ala Gly Thr Leu Gly Ser Tyr 1 5 10 15 Ala Met He Gly Val Met He Gly Ala Leu Ser Ala Gly Ala Val Gly 20 25 30 Asp Arg Leu Gly Arg Arg Lys Val Met Leu Thr Ala He Val Trp Phe 35 40 45 Ser Val Gly Met Ala Leu Thr Ala Phe Ala Ser Ser Ala Ala Leu Phe 50 55 60 Gly Phe Leu Arg Phe Leu Thr Gly Leu Gly Val Gly Met He Val Wing 65 70 75 80 Thr Gly Gly Wing He He Wing Glu Phe Wing Pro Wing Asn Arg Arg Asn 85. 90 95 Leu Phe Asn Wing He Val Tyr Ser Gly Val Pro Wing Gly Gly Val Leu 100 105 110 Wing Being He Leu Wing Leu Leu Phe Glu Asp Val He Gly Trp Arg Gly 115 120 10 125 Leu Phe Leu He Gly Gly Ser Pro Leu Leu Phe Leu Leu Pro Leu Wing 130 135 140 Tyr Phe Phe Leu Pro Glu Ser Pro Arg Trp Leu Thr Ser Arg Gly Arg • 145 150 155 160 Wing Wing Asp Wing Lys Wing Leu Cys Wing Arg Tyr Gly Leu Pro Thr Glu 165 170 175 Glu Phe Val Val Glu Lys Gln Gln Glu Thr Lys Gly Thr Gly Phe Wing 180 185 190 Gly He Phe Ser Ser Lys Tyr Leu Met Gly Thr He Leu He Gly Wing 195 200 205 Met Ser Phe He Gly Leu Leu Ser Thr Tyr Gly Leu Asn Thr Trp Leu 210 215 220 15 Pro Lys He Met Glu Ser Asn Gly Wing Thr Ser His Asp Ser Leu Tyr 225 230 235 240 Ser Leu Leu Phe Leu Asn Gly Gly Wing Val Phe Gly Gly Leu He Wing 245 250 255 Ser Trp Phe Wing Asp Arg He Gly Wing Lys Thr Val He Thr Ser Thr 260 265 270 Phe Ala Leu Ala Wing Cys Leu Gly Val Leu Pro Asn He Ser Ser 275 280 285 • Trp Pro Met Met Tyr Thr Wing He Wing Phe Wing Gly Val Gly Val Leu 290 295 300 Gly Thr Gln Val Leu Thr Tyr Gly Leu Thr Ser Asn Phe Phe Gly Thr 20 305 310 315 320 Glu Cys Arg Wing Wing Gly Val Wing Trp Cys Wing Wing Gly Phe Gly Arg Leu 325 330 335 Gly Gly He Val Gly Pro Wing He Gly Gly Leu He He Gly Wing Gly 340 345 350 Phe Gly Pro Ser Be Wing Phe Leu He Phe Wing Wing Wing Wing Wing 355 360 365 Gly Wing Val Cys Thr Leu Leu He Pro Arg Ser Pro Wing Glu Val Glu 370 375 380 Val Lys Val Wing Gln Glu Pro Leu Wing Arg Val 385 390 395 25 < 210 > 411 < 211 > 689 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (666) < 223 > RXA00962 • < 400 > 411 gat aag gcc ate aag gcg gat cae gac att aga gaa ggc falls gat gag 48 Asp Lys Ala He Lys Wing Asp His Asp He Arg Glu Gly His Asp Glu 1 5 10 15 cca gca ggt ttc aag gat ctg ctt gtc gat cgc tac cgc tgg ate tcc 96 Pro Ala Gly Phe Lys Asp Leu Leu Val Asp Arg Tyr Arg Trp He Ser 20 25 30 att tgg tcc gcg etc gcc here ttt gtc acc ctg etc gcg tgg tac gga 144 He Trp Phe Ala Leu Wing Thr Phe Val Thr Leu Leu Wing Trp Tyr Gly 35 40 45 ctg ggc here tgg ttg ect cgc etc atg gaa act gca ggt tat gag ttc 192 10 Leu Gly Thr Trp Leu Pro Arg Leu Met Glu Thr Wing Gly Tyr Glu Phe 50 55 60 ggc cat gca ttg atg ttc acc ctg gct ctg aac etc ggt gca gtg ate 240 Gly His Ala Leu Met Phe Thr Leu Ala Leu Asn Leu Gly Wing Val He • 65 70 75 80 gga tcc gtg gtt act gcg tgg gcc gcc gcc gcc gcc tcc ggg cca cct ct 288 Gly Ser Val Val Thr Ala Trp Wing Gly Asp Arg Phe Gly Pro He Arg 85 90 95 tcc ggt gtc ate gct gca ggt ate gcc ggt att gca ctg etc ctg ctg 336 Ser Gly Val He Wing Wing Gly He Wing Gly He Wing Leu Leu Leu Leu 100 105 110 etc act tac ccg ect gtc gc gtc tat gtc att att att ttg gct 384 15 Leu Thr Tyr Pro Pro Val Thr Wing Val Tyr Val He Leu He Leu Wing 115 120 125 ggc gg gg ggc acc ggc ggc act cag ate etc gtg att gca gcc gcc gt 432 Gly Val Gly Thr His Gly Thr Gln He Leu He He Ala Wing Val Ala 130 135 140 aac ttc tac cca age aac ctg cgt ggc here gca ctg ggc tgg gcg cta 480 Asn Phe Tyr Pro Ser Asn Leu Arg Gly Thr Ala Leu Gly Trp Ala Leu 145 150 155 160 ggt gta ggt cgt att ggt gct gtt gtg gcc ccg cag etc gct ggc ctg 528 Gly Val Gly Arg He Gly Ala Val Val Ala Pro Gln Leu Ala Gly Leu 165 170 175 ctg ctg gca tgg aac ttg ggc gtg aac tcc aac ttc ate atg tcc ggc 576 20 Leu Leu Ala Trp Asn Leu Gly Val Asn Ser Asn Phe He Met Phe Gly 180 185 190 ac gct gcg ctg etc tet gcg ctg gct etc age gtg ttg ctg cgc ctg 624 Thr Ala Ala Leu Leu Ser Ala Leu Ala Leu Ser Val Leu Leu Arg Leu 195 200 205 cag aaa acc tac age gtc acc aaa gtc gaa ate ca ggc 666 Gln Lys Thr Tyr Ser Val Thr His Lys Val Glu He Gln Gly 210 215 220 taaccccctt tttcaactca cag 689 < 210 > 412 < 211 > 222 25 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 412 Asp Lys Wing He Lys Wing Asp His Asp He Arg Glu Gly His Asp Glu 1 5 10 15 Pro Wing Gly Phe Lys Asp Leu Leu Val Asp Arg Tyr Arg Trp He Ser 20 25 30 He Trp Phe Wing Leu Wing Thr Phe Val Thr Leu Leu Wing Trp Tyr Gly 35 40 45 • Leu Gly Thr Trp Leu Pro Arg Leu Met Glu Thr Wing Gly Tyr Glu Phe 50 55 60 Gly His Wing Leu Met Phe Thr Leu Wing Leu Asn Leu Gly Wing Val He 65 70 75 80 Gly Ser Val Val Thr Ala Trp Ala Giy Asp Arg Phe Gly Pro He Arg 85 90 95 Ser Gly Val He Ala Ala Gly He Wing Gly He Wing Leu Leu Leu Leu Leu 100 105 110 Leu Thr Tyr Pro Pro Val Thr Wing Val Tyr Val He Leu He Leu Wing 115 120 125 Gly Val Gly Thr His Gly Thr Gln He Leu He He Ala Wing Val Wing 10 130 135 140 Asn Phe Tyr Pro Ser Asn Leu Arg Gly Thr Wing Leu Gly Trp Wing Leu 145 150 155 160 Gly Val Gly Arg He Gly Wing Val Val Wing Pro Gln Leu Wing Gly Leu • 165 170 175 Leu Leu Wing Trp Asn Leu Gly Val Asn Be Asn Phe He Met Phe Gly 180 185 190 Thr Ala Ala Leu Leu Ser Ala Leu Ala Leu Ser Val Leu Leu Arg Leu 195 200 205 Gln Lys Thr Tyr Ser Val Thr His Lys Val Glu He Gln Gly 210 215 220 15 < 210 > 413 < 211 > 484 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (484) < 223 > RXA028H < 400 > 413 cataatcact ctttccagat agcggaatcc etttgattgt aacttggctc aectegatta 60 20 tgtgtttatg acatcacacg caccagaatc gggaggactt gtg here gag tea act 115 Val Thr Glu Be Thr 1 5 etc gga gca tcg aat age tcc caá here att gaa aat aaa ggc etc acc 163 Leu Gly Wing Being Asn Being Ser Gln Thr He Glu Asn Lys Gly Leu Thr 10 15 20 ate ttg ggc ate age ggc cga cgc ttg gct gcg gtg etc att ggc tgg 211 He Leu Gly He Ser Gly Arg Arg Leu Ala Wing Val Leu He Gly Trp 25 30 35 ttt ttt gtc att ttc gac ggc tac gac etc att gtg tac ggc acc gtc 259 Phe Phe Val He Phe Asp Gly Tyr Asp Leu He Val Tyr Gly Thr Val 40 45 50 25 cac tcg gcc ctg gct aag gag tgg aac tta age tet gca acg ctg ggc 307 Gln Ser Ala Leu Ala Lys Glu Trp Asn Leu Ser Ser Ala Thr Leu Gly 55 60 65 acc ate ggc tcc acc gcg ttc ttt ggc atg gcg ate ggc gct gtg ttc 355 Thr He Gly Be Thr Wing Phe Phe Gly Met Wing He Gly Wing Val Phe 70 75 80 85 att ggt cga ctg tea gac cgc ggg ggc cga aaa gca gcg gtg att gga 403 He Gly Arg Leu Ser Asp Arg Val Gly Arg Lys Ala Wing Vai He Gly 90 95 100 tcc gtg ctg att etc tet gtc ttc acc atg ctg tgt gca ttt gct cca 451 Ser Val Leu He Leu Ser Val Phe Thr Met Leu Cys Wing Phe Wing Pro 105 110 115 aac cca tgg gtg ttc ggc gct tc ct ct ttc ate 484 Asn Pro Trp Val Phe Gly Wing Phe Arg Phe He 120 125 < 210 > 414 < 211 > 128 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 414 Val Thr Glu Ser Thr Leu Gly Ala Ser Asn Ser Ser Gln lhr He Glu 1 5 10 15 Asn Lys Gly Leu Thr He Leu Gly He Ser Gly Arg Arg Leu Wing Wing 20 25 30 Val Leu He Gly Trp Phe Phe Val He Phe Asp Gly Tyr Asp Leu He 35 40 45 Val Tyr Gly Thr Val Gln Ser Wing Leu Ala Lys Glu Trp Asn Leu Ser 50 55 60 Be Wing Thr Leu Gly Thr He Gly Be Thr Wing Phe Phe Gly Met Wing 65 70 75 80 He Gly Wing Val Phe He Gly Arg Leu Ser Asp Arg Val Gly Arg Lys 85 90 95 Ala Ala Val He Gly Ser Val Leu He Leu Ser Val Phe Thr Met Leu 100 105 110 Cys Ala Phe Ala Pro Asn Pro Trp Val Phe Gly Ala Phe Arg Phe He 115 120 125 < 210 > 415 < 211 > 1197 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (1197) < 223 > RXA02115 < 400 > 415 acc cgc gca acc aaa agt gtc gga here gtt etc gca etc ctg tgg ttc 48 Thr Arg Wing Thr Lys Ser Val Gly Thr Val Leu Wing Leu Leu Trp Phe 1 5 10 15 gca att gtc etc gac ggc ttt gac cta gtc gtc ctg ggt gca here ate 96 Wing He Val Leu Asp Gly Phe Asp Leu Val Val Leu Gly Wing Thr He 20 25 30 ccg tcc atg ctg gag gat ccc gcg tgg gat etc. act gct gga cag gcc 144 Pro Ser Met Leu Glu Asp Pro Ala Trp Asp Leu Thr Ala Gly Gln Ala -i ti 35 40 45 here cag att ctc acc ate ggc etc gtc ggc atg acc att ggc gca ctg 192 Thr Gln He Ser Thr He Gly Leu Val Gly Met Thr He Gly Ala Leu 50 55 60 acc ate ggt ttc tta acg gac cgt ctg ggt cgc cgc cgt gtc atg ctg 240 Thr He Gly Phe Leu Thr Asp Arg Leu Gly Arg Arg Arg Val Met Leu 65 70 75 80 t'tc tet gtg gca gta ttt tet gt ttc act etc ctg ctg gca ttc acc 288 Phe Ser Val Val Val Phe Ser Val Phe Thr Leu Leu Leu Ala Phe Thr • 85 90 95 acc aac gtc cag etc ttc age ctg tgg cgt ttc etc gca ggt gtt ggc 336 Thr Asn Val Gln Leu Phe Ser Leu Trp Arg Phe Leu Wing Gly Val Gly 100 105 110 ctt ggt gga gca etc ccc acc gca att gcc atg gtg acc gag ttc cgc 384 Leu Gly Gly Ala Leu Pro Thr Ala He Wing Met Val Thr Glu Phe Arg 115 120 125 ccc ggc acc aaa gcg ggc tet gca tcc acc acc ttg atg acc ggc tac 432 Pro Gly Thr Lys Ala Gly Ser Wing Be Thr Thr Leu Met Thr Gly Tyr 130 135 140 fall gtc ggc gca gta gca acc gcc ttc ctt ggc etc ttc ctt ate gac 480 His Val Gly Ala Val 10 Wing Thr Wing Phe Leu Gly Leu Phe Leu He Asp 145 150 155 160 ggc ttt ggt tgg drops tcc atg ttc ate gca ggt gcc gta cca gga ctg 528 Gly Phe Gly Trp His Ser Met Phe He Wing Gly Wing Val Pro Gly Leu 165 170 175 ate ctg cta ct ctg ctg tc tc ct tc ct cca gaa tcc ccg cag tac 576 He Leu Leu Pro Leu Leu Tyr Phe Phe Leu Pro Glu Pro Pro Gln Tyr 180 185 190 etc aaa ate tcc ggc aag ttg gat gag gcg cag gca gtt gca gca tet 624 Leu Lys He Be Gly Lys Leu Asp Glu Wing Gln Wing Val Wing Wing Ser 195 200 205 tat gga ctt tcc ctg gat gat gat ctt gat cgc gaa cae gaa gaa gaa 672 15 Tyr Gly Leu Ser Leu Asp Asp Asp Leu Asp Arg Glu His Glu Glu Glu 210 215 220 etc ggc gag tcc tcc tea ctt tcc tcc ctg ttc aag ecc tcg ttc cgc 720 Leu Gly Glu Being Ser Leu Being Ser Leu Phe Lys Pro ber Phe Arg 225 230 235 240 cgc aac acc ctg gcg att tgg ggc acc tea ttc atg gga etc etc ctg 768 Arg Asn Thr Leu Wing He Trp Gly Thr Ser Phe Met Gly Leu Leu Leu 245 250 255 gtc tac ggc ctg aac here tgg ctg cca ca ate ate cgc ca gca gac 816 • Val Tyr Gly Leu Asn Thr Trp Leu Pro Gln He Met Arg Gln Wing Asp 260 265 270 tac gac atg ggt aac tcg ctt gga ttc etc atg gtg etc aac ate ggc 864 20 Tyr Asp Met Gly Asn Ser Leu Gly Phe Leu Met Val Leu Asn He Gly 275 280 285 gca gtg ate ggc ctt tat att gca ggg cga att gcc gat aag aac tcc 912 Wing Val He Gly Leu Tyr He Wing Wing Gly Arg He Wing Asp Lys Asn Ser 290 295 300 ect cgc aaa here gca etc gta tgg ttc gtg ttc tet gca ttt tcc etc 960 Pro Arg Lys Thr Ala Leu Val Trp Phe Val Phe Ser Ala Phe Ser Leu 305 310 315 320 gcg ttg ctt gct gtc cgg atg cca ctg ate ggt ctg tat ggc ate gtg 1008 Ala Leu Leu Ala Val Arg Met Pro Leu He Gly Leu Tyr Gly He Val 325 330 335 ctg etc acc ggc ate ttt gtg ttc age tcc cag gta etc ate tac gcc 1056 25 Leu Leu Thr Gly He Phe Val Phe Ser Ser Gln Val Leu He Tyr Wing 340 345 350 ttc gtt ggt gag aat falls ect gcc aag atg cgc gca acc gcc atg gga 1104 Phe Val Gly Glu Asn His Pro Ala Lys Met Arg Ala Thr Wing Met Gly 355 360 365 ttc tcc gca gga att ggt cgc gcc gcc gcc gtc ttg ctt 1152 Phe Ser Wing Gly He Gly Arg Leu Gly Wing Be Gly Pro Leu Leu 370 375 380 ggt gtc gtt ctg ctt gtc agt gcc aac ctt gct tac cca tgg ggc ttc 1197 Gly Gly Leu Leu Val Being Wing Asn Leu Wing Tyr Pro Trp Gly Phe 385 390 395 < 210 > 416 < 211 > 399 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 416 Thr Arg Wing Thr Lys Ser Val Gly Thr Val Leu Wing Leu Leu Trp Phe 1 5 10 15 Wing He Le Val Leu Asp Gly Phe Asp Leu Val Val Leu Gly Wing Thr He 10 20 25 30 Pro Ser Met Leu Glu Asp Pro Wing Trp Asp Leu Thr Ala Gly Gln Wing 35 40 45 Thr Gln Be Ser Thr He Gly Leu Val Gly Met Thr He Gly Ala Leu • 50 55 60 Thr He Gly Phe Leu Thr Asp Arg Leu Gly Arg Arg Arg Val Met Leu 65 70 75 80 Phe Ser Val Wing Val Phe Ser Val Phe Thr Leu Leu Leu Wing Phe Thr 85 90 95 Thr Asn Val Gln Leu Phe Ser Leu Trp Arg Phe Leu Wing Gly Val Gly 100 105 110 Leu Gly Gly Wing Leu Pro Thr Wing He Wing Met Val Thr Glu Phe Arg 15 115 120 125 Pro Gly Thr Lys Wing Gly Ser Wing Thr Thr Leu Met Thr Gly Tyr 130 135 140 His Val Gly Wing Val Wing Thr Wing Phe Leu Gly Leu Phe Leu He Asp 145 150 155 160 Gly Phe Gly Trp His Ser Met Phe He Wing Wing Gly Wing Val Pro Gly Leu 165 170 175 He Leu Leu Pro Leu Leu Tyr Phe Phe Leu Pro Glu Ser Pro Gln Tyr 180 185 190 • Leu Lys He Ser Gly Lys Leu Asp Glu Ala Gln Ala Val Ala Ala Ser 1 95 200 205 Tyr Gly Leu Ser Leu Asp Asp Asp Leu Asp Arg Glu His Glu Glu Glu 20 210 215 220 Leu Gly Glu Ser Ser Leu Ser Ser Leu Phe Lys Pro Ser Phe Arg 225 230 235 240 Arg Asn Thr Leu Ala He Trp Gly Thr Ser Phe Met Gly Leu Leu Leu 245 250 255 Val Tyr Gly Leu Asn Thr Trp Leu Pro Gln He Met Arg Gln Wing Asp 260 265 270 Tyr Asp Met Gly Asn Ser Leu Gly Phe Leu Met Val Leu Asn He Gly 275 280 285 Ala Val He Gly Leu Tyr He Wing Wing Gly Arg He Wing Asp Lys Asn Ser 290 295 300 Pro Arg Lys Thr Wing Leu Val Trp Phe Val Phe Ser Wing Phe Ser Leu 25 305 310 315 320 Wing Leu Leu Wing Val Arg Met Pro Leu He Gly Leu Tyr Gly He Val 325 330 335 Leu Leu Thr Gly He Phe Val Phe Ser Ser Gln Val Leu He Tyr Wing 340 345 350 Phe Val Gly Glu Asn His Pro Ala Lys Met Arg Ala Thr Ala Met Gly 355 360 365 Phe Ser Ala Gly He Gly Arg Leu Gly Wing He Ser Gly Pro Leu Leu 370 375 380 • Gly Gly Leu Leu Val Being Wing Asn Leu Wing Tyr Pro Trp Gly Phe 385 390 395 < 210 > 417 < 211 > 1288 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1288) < 223 > RXN00590 10 < 400 > 417 tctaaactca < ? tctcaactc a < ccaagattg tttcaac; aatc tgcgattggt < gtgcaatcta 60 ccccaatcat 1tttgaaagcc cccacgaaag gagcgcgaca atg gcc gac aac aaa 115 Met Wing Asp Lys 1 5 aat gcc gat gac age cag cta gtc tea gcc age act gga acc ect ggg 163 Asn Wing Asp Asp Ser Gln Leu Val Ser Wing Being Thr Gly Thr Pro Gly 10 15 20 ect ggc gac att gca aaa gcc aat gcg cca tcc etc aag ca gct gca 211 Pro Gly Asp He Ala Lys Ala Asn Ala Pro Ser Leu Lys Gln Ala Ala 25 30 35 15 gta acc gcc tet ggc cga age gct ctg atg ggt gcc ate ttc etc atg 259 Val Thr Wing Ser Gly Arg Be Wing Leu Met Gly Wing He Phe Leu Met 40 45 50 gca act tet gcc ate ggc cca ggg ttc etc acc atact gct gtc ttc 307 Wing Thr Ser Wing He Gly Pro Gly Phe Leu Thr Gln Thr Wing Val Phe 55 60 65 acc aac cag etc ggc gca gct ttc gca ttt gcg ate ctg gtg tcg ate 355 Thr Asn Gln Leu Gly Ala Ala Phe Ala Phe Ala He Leu Val Ser He 70 75 80 85 • etc att gac ate gcg gtg cag ctg aat gtg tgg cgc ate ate ggc gtc 403 Leu He Asp He Wing Val Gln Leu Asn Val Trp Arg He He Gly Val 90 95 100 20 tet gaa atg cgc gcc caa gaa etc ggc aac acg gtt ate cca ggt ttt 451 Be Glu Met Arg Ala Gln Glu Leu Gly Asn Thr Val He Pro Gly Phe 105 110 115 ggt tgg gtg ctg gcc gta ctg gtc tgt att ggc ggc gta gta ttc aac 499 Gly Trp Val Leu Wing Val Leu Val Cys He Gly Gly Val Val Phe Asn 120 125 130 ate ggc aac ate gcc ggt ggt ggc ctt ggg ctt aac gcg ctg ctt ggc 547 He Gly Asn He Wing Gly Gly Gly Leu Gly Leu Asn Wing Leu Leu Gly 135 140 145 tgg gac gtc aaa gtt ggt ggc gtg ate gcg gcc gcg att gcg 595 Trp Asp Val Lys Val Gly Gly Val He Thr Wing Wing He Wing Wing Wing 150 155 160 165 25 ttc ttc ttc tgc aag cga ctt ggt gct gct ctg gac aaa ttc etc gtg 643 He Phe Leu Phe Lys Arg Leu Gly Ala Ala Leu Asp Lys Phe Leu Val 170 175 180 gtc etc ggc gtc gtg atg ate ctg etc acc gtc tac gtg gct ttc gtc 691 Val Leu Gly Val Val Met He Leu Leu Thr Val Tyr Val Wing Phe Val 185 190 195 tcc ca ect cca gtt ggc tcg gcg ctg aag aat gca gta ctt ect gac 739 Ser Gln Pro Pro Val Gly Be Ala Leu Lys Asn Ala Val Leu Pro Asp 200 205 210, acc ate gac tgg ctt gtc ate acc acta ctt gtg ggt gga acc gtc ggt 787 • Thr He Asp Trp Leu Val He Thr Thr Leu Val Gly Gly Thr Val Gly 215 220 225 gga tac ate act tac gct ggc gca cae cgc atg ctg gac tcc gga cga 835 Gly Tyr He Thr Tyr Wing Gly Wing His Arg Met Leu Asp Ser Gly Arg 230 235 240 245 cc aac aac aac gtc aaa gct gtt tcc aat tcc tet ate acc ggc 883 Thr Gly Pro Asn Asn Val Lys Wing Val Ser Asn Ser Ser He Thr Gly 250 255 260 ate ctg ate act ggc etc atg cgc gtg gtg etc ttc etc gcg gtt etc 931 He Leu He Thr Gly Leu Met Arg Val Val Leu Phe Leu Ala Val Leu 265 270 275 10 ggt gtt gtc gca ggt ggc gtc acccta tcc ac acg ggc aac cca gcc 979 Gly Val Val Wing Gly Gly Val Thr Leu Ser Thr Thr Gly Asn Pro Wing 280 285 290 gcg gaa gca ttc cag drops gct gca ggc gat ate gga cta cgc ate ttc 1027 • Wing Glu Wing Phe Gln His Wing Wing Gly Asp He Gly Leu Arg He Phe 295 300 305 ggc gcc gtg ctg tgg gca gcg tcc att tcc tea gtc ate ggc gcc age 1075 Gly Wing Val Leu Trp Wing Wing Being Ser Val Ser Gly Wing Ser 310 315 320 325 tac acc tet gca acc ttc ctg gtg gaa aac aag cca gag aag aag cgt 1123 Tyr Thr Ser Ala Thr Phe Leu Val Glu Asn Lys Pro Glu Lys Lys Arg 330 335 340 15 ctg caa aac tgg gtg acc ate ate ttc ate ctg att tet tgc tcc gtg 1171 Leu Gln Asn Trp Val Thr He He Phe He Leu He Ser Cys Ser Val 345 350 355 ttc ate atg etc ggc acg gca cca gca ate etc ttg gtc ttc gcc gga 1219 Phe He Met Leu Gly Thr Wing Pro Wing He Leu Leu Val Phe Wing Gly 360 365 370 gca ttc aac ggt ttg gtc etc ccc gta ggc ttt acc ctg atg ate tac 1267 Wing Phe Asn Gly Leu Val Leu Pro Val Gly Phe Thr Leu Met He Tyr 375 380 385 • gta gcg ate ttc cgc caa aaa 1288 Val Ala He Phe Arg Gln Lys 390 395 20 < 210 > 418 < 211 > 396 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 418 Met Wing Asp Asn Lys Asn Wing Asp Asp Ser Gln Leu Val Ser Wing Being 1 5 10 15 Thr Gly Thr Pro Gly Pro Gly Asp He Wing Lys Wing Asn Wing Pro Being 20 '25 30 Leu Lys Gln Wing Wing Val Thr Wing Being Gly Arg Be Wing Leu Met Gly 25 35 40 45 Wing He Phe Leu Met Wing Thr Be Wing He Gly Pro Gly Phe Leu Thr 50 55 60 Gln Thr Wing Val Phe Thr Asn Gln Leu Gly Wing Wing Phe Wing Phe Wing 65 70 75 80 He Leu Val Ser He Leu He Asp He Wing Val Gln Leu Asn Val Trp 85 90 95 Arg He He Gly Val Ser Glu Met Arg Wing Gln Glu Leu Gly Asn Thr 100 105 110 Val He Pro Gly Phe Gly Trp Val Leu Ala Val Leu Val Cys He Gly 115 120 125 Gly Val Val Phe Asn He Gly Asn He Wing Gly Gly Gly Leu Gly Leu 130 135 140 Asn Wing Leu Leu Gly Trp Asp Val Lys Val Gly Gly Val He Thr Wing 145 150 155 160 Ala He Ala Ala Ala He Phe Leu Phe Lys Arg Leu Gly Ala Ala Leu 165 170 175 Asp Lys Phe Leu Val Val Leu Gly Val Val Met He Leu Leu Thr Val 180 185 190 Tyr Val Ala Phe Val Ser Gln Pro Pro Val Gly Ser Wing Leu Lys Asn 195 200 205 Wing Val Leu Pro Asp Thr He Asp Trp Leu Val He Thr Thr Leu Val 210 215 220 Gly Gly Thr Val Gly Gly Tyr He Thr Tyr Wing Gly Wing His Arg Met 225 230 235 240 Leu Asp Ser Gly Arg Thr Gly Pro Asn Asn Val Lys Wing Val Ser Asn 245 250 255 Ser Ser He Thr Gly He Leu He Thr Gly Leu Met Arg Val Val Leu 260 265 270 Phe Leu Wing Val Leu Gly Val Val Wing Gly Gly Val Thr Leu Ser Thr 275 280 285 Thr Gly Asn Pro Wing Wing Glu Wing Phe Gln His Wing Wing Gly Asp He 290 295 300 Gly Leu Arg He Phe Gly Wing Val Leu Trp Wing Wing Being Be Ser 305 310 315 320 Val He Gly Wing Ser Tyr Thr Ser Wing Thr Phe Leu Val Glu Asn Lys 325 330 335 Pro Glu Lys Lys Arg Leu Gln Asn Trp Val Thr He He Phe He Leu 340 345 350 He Ser Cys Ser Val Phe He Met Leu Gly Thr Ala Pro Ala He Leu 355 360 365 Leu Val Phe Ala Gly Ala Phe Asn Gly Leu Val Leu Pro Val Gly Phe 370 375 380 Thr Leu Met He Tyr Val Wing He Phe Arg Gln Lys 385 390 395 < 210 > 419 < 211 > 487 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (487) < 223 > FRXA00590 < 400 > 419 tacgctggcg cacaccgcat gctggactcc ggacgaaccg gccccaacac gtcaaagctg 60 tttecaatte tctatcaccg gcatcctgat cactggcctc atg cgc gtg gtg etc. 115 Met Arg Val Val Leu 1 5 ttc etc gcg gtt etc ggt gtt gtc gca ggt ggc gtc acc cta tcc acc 163 Phe Leu Ala Val Leu Gly Val Val Wing Gly Gly Val Thr Leu Ser Thr 10 15 20 acg ggc aac cca gcc gcg gaa gca ttc cag drops gct gca ggc gat ate 211 Thr Gly Asn Pro Wing Wing Glu Wing Phe Gln His Wing Wing Gly Asp He 25 30 35 gga cta cgc ate ttc ggc gcc gtg ctg tgc gca gcg tcc att tcc tea 259 Gly Leu Arg He Phe Gly Wing Val Leu Trp Wing Wing Being Ser 40 45 50 gtc ate ggc gcc age tac acc tet gca acc ttc ctg gtg gaa aac aac aa 307 Val He Gly Wing Ser Tyr Thr Ser Wing Thr Phe Leu Val Glu Asn Lys 55 60 65 cca gag aag aag cgt ctg caa aac tgg gtg acc ate ate ttc ate ctg 355 Pro Glu Lys Lys Arg Leu Gln Asn Trp Val Thr He He Phe He Leu 70 75 80 85 att tet tgc tcc gtg ttc ate atg etc ggc acg gca cca gca aattee eettcc 403 I Ser Cys Ser Val Phe He Met Leu Gly Thr Wing Pro Wing He Leu 90 95 100 ttg gtc ttc gcc gga gca gtc aac ggt ttg gtc etc ccc gta ggggcc tttttt 451 Leu Val Phe Ala Gly Ala Phe Asn Gly Leu Val Leu Pro Val Gly Phe 105 110 115 acc att ate tac gta gcg ate tc cc a ca aa 487 Thr Leu Met He Tyr Val Wing He Phe Arg Gln Lys 120 125 < 210 > 420 < 211 > 129 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 420 Met Arg Val Val Leu Phe Leu Ala Val Leu Gly Val Val Ala Gly Gly 1 5 10 15 Val Thr Leu Ser Thr Thr Gly Asn Pro Wing Wing Glu Wing Phe Gln His 20 25 30 Wing Wing Gly Asp He Gly Leu Arg He Phe Gly Wing Val Leu Trp Wing 35 40 45 Wing Being Ser Val Ser Gly Wing Ser Tyr Thr Ser Wing Thr Phe 50 55 60 Leu Val Glu Asn Lys Pro Glu Lys Lys Arg Leu Gln Asn Trp Val Thr 65 70 75 80 He He Phe He Leu He Ser Cys Ser Val Phe He Met Leu Gly Thr 85 90 95 Wing Pro Wing He Leu Leu Val Phe Wing Gly Wing Phe Asn Gly Leu Val 100 105 110 Leu Pro Val Gly Phe Thr Leu Met He Tyr Val Wing He Phe Arg Gln 115 120 125 Lys < 210 > 421 < 211 > 490 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (490) < 223 > FRXA01538 < 400 > 421 tetaaaetca < tCttcaaetc accaagatttg ttteaacaatc tgcgattggt < gtgc; aateta 60 ccccaatt = at 1tttg; aaagee cccacgaaag ga < gegetgaca atg gcc gac aac aaa 115 Met Wing Asp Asn Lys 1 5 aat gcc gat gac age cag cta gtc tea gcc age act gga acc ect ggg 163 Asn Wing Asp Asp Ser Gln Leu Val Ser Wing Being Thr Gly Thr Pro Gly 10 15 20 ect ggc gac att gca aaa gcc aat gcg cca tcc etc aag ca gct gca 211 Pro Gly Asp He Wing Lys Wing Asn Wing Pro Being Leu Lys Gln Wing Wing 25 30 35 gta acc gcc tet ggc cga age gct ctg atg ggt gcc ate ttc etc atg 259 Val Thr Wing Ser Gly Arg Be Wing Leu Met Gly Wing He Phe Leu Met 40 45 50 gca act tet gcc ate ggc cca ggg ttc etc acc atact gct gtc ttc 307 Wing Thr Ser Wing He Gly Pro Gly Phe Leu Thr Gln Thr Wing Val Phe 55 60 65 acc aac cag etc ggc gca gct ttc gca ttt gcg ate ctg gtg tcg ate 355 Thr Asn Gln Leu Gly Ala Ala Phe Ala Phe Ala He Leu Val Ser He 70 75 80 85 etc att gac ate gcg gtg cag ctg aat gtg tgg cgc ate ate ggc gtc 403 Leu He Asp He Wing Val Gln Leu Asn Val Trp Arg He He Gly Val 90 95 100 tet gaa atg cgc gcc caa gaa etc ggc aac acg gtt ate cca ggt ttt 451 Ser Glu Met Arg Ala Gln Glu Leu Gly Asn Thr Val He Pro Gly Phe 105 110 115 ggt tgg gtg ctg gcc gta ctg gtc tgt att ggc ggc gta 490 Gly Trp Val Leu Wing Val Leu Val Cys He Gly Gly Val 120 125 130 < 210 > 422 < 211 > 130 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 422 Met Wing Asp Asn Lys Asn Wing Asp Asp Ser Gln Leu Val Ser Wing Being 1 5 10 15 Thr Gly Thr Pro Gly Pro Gly Asp He Wing Lys Wing Wing Asn Wing Pro Being 20 25 30 Leu Lys Gln Wing Wing Val Thr Wing Being Gly Arg Be Wing Leu Met Gly 35 40 45 Wing He Phe Leu Met Wing Thr Be Wing He Gly Pro Gly Phe Leu Thr 50 55 60 Gln Thr Wing Val Phe Thr Asn Gln Leu Gly Wing Wing Phe Wing Phe Wing 65 70 75 80 He Leu Val Ser He Leu He Asp He Wing Val Gln Leu Asn Val Trp 85 90 95 Arg He He Gly Val Ser Glu Met Arg Ala Gln Glu Leu Gly Asn Thr 100 105 110 Val He Pro Gly Phe Gly Trp Val Leu Ala Val Leu Val Cys He Gly 115 120 125 t,? ....? . *. I. ^^^ ¿^^^ Gly Val 130 < 210 > 423 < 211 > 1401 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > • < 221 > CDS < 222 > (101) .. (1378) < 223 > RXA01727 < 400 > 423 agettttggt iggtttcacca c < ctgcigctcig tcttaatttt gcgtgtticca < gagatgacect 60 tgaggagggg ictgcgccgta ticgccagcgt gttgtaaata atg agt aaa aag tet 115 Met Ser Lys Lys Ser 1 5 gtc ctg att act tet ttg atg ctg ttt tcc atg ttc ttc gga gct gga 163 Val Leu He Thr Ser Leu Met Leu Phe Ser Met Phe Phe Gly Wing Gly 10 10 15 20 aac etc ate ttc ccg ccg atg ctt gga ttg tcg gca gga acc aac tat 211 Asn Leu He Phe Pro Pro Met Leu Gly Leu Ser Wing Gly Thr Asn Tyr 25 30 35 • cta cca gct ate tta gga ttt cta gca acg agt gtt ctg etc ccg gtg 259 Leu Pro Ala He Leu Gly Phe Leu Wing Thr Ser Val Leu Leu Pro Val 40 45 50 ctg gcg att ate gcg gtg gtg ttg tcg gga gaa aat gtc aag gac atg 307 Leu Ala He He Wing Val Val Leu Ser Gly Glu Asn Val Lys Asp Met 55 60 65 gct tet cgt ggc ggt aag ate ttt ggc ctg gtg ttt ect att gct gcc 355 Wing Being Arg Gly Gly Lys He Phe Gly Leu Val Phe Pro He Wing Wing 15 70 75 80 85 tat ttg tet ate ggc gcg ttt tac gcg ctg ccg agg act ggg gcg gtg 403 Tyr Leu Ser He Gly Wing Phe Tyr Wing Leu Pro Arg Thr Gly Wing Val 90 95 100 age tat tcg acg gcg gtt ggc gtc gat aat gcg ctt tat tcg ggc ttg 451 Ser Tyr Ser Thr Wing Val Gly Val Asp Asn Wing Leu Tyr Ser Gly Leu 105 110 115 ttt aac ttt gtg ttt ttt gcg gtg gca ctg gcg ttg tcg tgg aat ccg 499 Phe Asn Phe Val Phe Phe Ala Val Ala Leu Ala Leu Ser Trp Asn Pro 120 125 130 aat ggc att gca gac aag ttg ggt aag tgg etc acg cca gcg ttg etc 547 Asn Gly He Wing Asp Lys Leu Gly Lys Trp Leu Thr Pro Wing Leu Leu 20 135 140 145 acg ttg att gtg gtg ctg gtg gtg ttg tcg gta gcc aag ttg gat ggc 595 Thr Leu He Val Val Leu Val Val Leu Ser Val Ala Lys Leu Asp Gly 150 155 160 165 acg cca ggt gag cca agt gcg tat gcg cag ect gcg ggg gcg 643 Thr Pro Gly Glu Pro Ser Wing Tyr Wing Gln Gln Pro Wing Gly Wing 170 175 180 ggt ttg ctt gag ggc tac atg acg atg gat gcg att gct gcg ttg gcg 691 Gly Leu Leu Glu Gly Tyr Met Thr Met Asp Ala He Ala Ala Leu Ala 185 190 195 ttt ggc ate gtg gtg att tet gcg ttc aag tac ca aag gtt aac aag 739 Phe Gly He Val Val He Ser Wing Phe Lys Tyr Gln Lys Val Asn Lys 25 200 205 210 gtc cgc acg gca act gtc gtg tcg gcg ttc att gcc gga att ttg ttg 787 Val Arg Thr Ala Thr Val Val Ser Ala Phe He Ala Gly He Leu Leu 215 220 225 gcg ctg gtt tat ctt ggt ttg ggc tea ate ggt ca gta gta aac ggt 835 Ala Leu Val Tyr Leu Gly Leu Gly Ser He Gly Gln Val Val Asn Gly 230 235 240 245 gag ttc gct gat ggc acc gca att ttg aac tac gct gca ctg tcc acg 883 Glu Phe Wing Asp Gly Thr Wing He Leu Asn Tyr Wing Wing Leu Ser Thr 250 255 260 atg ggt cag gct ggt cgc ate atg ttc gtg gct att ttg ate ctt gca 931 Met Gly Gln Wing Gly Arg He Met Phe Val Wing He Leu He Leu Wing 265 270 275 tgt atg acc gca gtt gt gt gt gtc gtg gtg gtg gtg tgt tgc tgt Cys Met Thr Thr Wing Val Gly Leu He Ser Wing Thr Ser Glu Phe Phe 280 285 290 aat tcg ctg ctg cca ggt gtc aag tac falls gtc tgg gcc act gtt ttc 1027 Asn Ser Leu Leu Pro Gly Val Lys Tyr His Val Trp Wing Thr Val Phe 295 300 305 gcg ctg att tcc ttt ggc gtt gcc acc atg ggt ttg gat acg gtg ttg 1075 Wing Leu He Being Phe Gly Val Wing Thr Met Gly Leu Asp Thr Val Leu 310 315 320 325 gcc gtt gcg gct cca gtg att agt ttc att tac cca tcg gcc ate acc 1123 Wing Val Wing Wing Pro Val He Be Phe He Tyr Pro Wing Be Thr 330 335 340 ttg gtg ttc ttg tcg etc ate gag ccc ctg ctg ttc cgt etc aag tgg 1171 Leu Val Phe Leu Ser Leu He Glu Pro Leu Leu Phe Arg Leu Lys Trp 345 350 355 t tac ttac tc tc tc tc t tc tc tc tc tc tcc tcc atc Thr Tyr Leu Phe Gly He Trp Thr Wing Val Val Trp Wing Leu Phe Met 360 365 370 tet ate ect gcg ctg aat cca ttc ate gaa tgg gcg ccg ctg fall age 1267 Ser He Pro Ala Leu Asn Pro Phe He Glu Trp Wing Pro Leu His Ser 375 380 385 atg tet tg ggg ggg ggg ggg gtc gtg gtg gtg gtg Met Ser Leu Gly Trp Val Val Pro Val Leu Val Ala Ser Ala He Gly 390 395 400 405 ttg gct att gat agg aag a ggt gcc cag tet gtt gca aag aag 1363 Leu Ala He Asp Trp Asn Lys Lys Gly Ala Gln Ser Val Ala Lys Lys 410 415 420 gaa tcc att tcc gtc taat: cgct: aa ttgcgaggag te: t 1401 Glu Ser He Ser Val 425 < 210 > 424 < 211 > 426 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 424 Met Ser Lys Lys Ser Val Leu He Thr Ser Leu Met Leu Phe Ser Met 1 5 10 15 Phe Phe Gly Wing Gly Asn Leu He Phe Pro Pro Met Leu Gly Leu Ser 20 25 30 Wing Gly Thr Asn Tyr Leu Pro Wing He Leu Gly Phe Leu Wing Thr Ser 35 40 45 Val Leu Leu Pro Val Leu Wing He He Wing Val Val Leu Ser Gly Glu 50 55 60 Asn Val Lys Asp Met Wing Wing Arg Gly Gly Lys He Phe Gly Leu Val 65 70 75 80 Phe Pro He Wing Wing Tyr Leu Ser He Gly Wing Phe Tyr Wing Leu Pro 85 90 95 Arg Thr Gly Wing Val Ser Tyr Ser Thr Wing Val Gly Val Asp Asn Wing 100 105 110 Leu Tyr Ser Gly Leu Phe Asn Phe Val Phe Phe Wing Val Ala Leu Ala 115 120 125 Leu Ser Trp Asn Pro Asn Gly He Wing Asp Lys Leu Gly Lys Trp Leu 130 135 140 Thr Pro Wing Leu Leu Thr Leu He Val Val Leu Val Val Leu Ser Val 145 150 155 160 Wing Lys Leu Asp Gly Thr Pro Gly Glu Pro Be Wing Tyr Wing Gln 165 170 175 Gln Pro Wing Gly Wing Gly Leu Leu Glu Gly Tyr Met Thr Met Wing Asp Wing 180 185 190 Wing Wing Wing Leu Wing Phe Gly He Val Val Healing Wing Phe Lys Tyr 195 200 205 Gln Lys Val Asn Lys Val Arg Thr Wing Thr Val Val Ser Wing Phe He 210 215 220 Wing Gly He Leu Leu Wing Leu Val Tyr Leu Gly Leu Gly Ser He Gly 225 230 235 240 Gln Val Val Asn Gly Glu Phe Wing Asp Gly Thr Wing He Leu Asn Tyr 245 250 255 Ala Ala Leu Ser Thr Met Gly Gln Ala Gly Arg He Met Phe Val Ala 260 265 270 He Leu He Leu Ala Cys Met Thr Thr Ala Val Gly Leu He Ser Wing 275 280 285 Thr Ser Glu Phe Phe Asn Ser Leu Leu Pro Gly Val Lys Tyr His Val 290 295 300 Trp Wing Thr Val Phe Wing Leu He Ser Phe Gly Val Wing Thr Met Gly 305 310 315 320 Leu Asp Thr Val Leu Ala Val Ala Ala Pro Val He Ser Phe He Tyr 325 330 335 Pro Be Wing He Thr Leu Val Phe Leu Ser Leu He Glu Pro Leu Leu 340 345 350 Phe Arg Leu Lys Trp Thr Tyr Leu Phe Gly He Trp Thr Ala Val Val 355 360 365 Trp Wing Leu Phe Met Ser He Pro Wing Leu Asn Pro Phe He Glu Trp 370 375 380 Pro Wing Leu His Ser Met Leu Gly Trp Val Val Pro Pro Val Leu Val 385 390 395 400 Wing Being Wing He Gly Leu Wing He Asp Trp Asn Lys Lys Gly Wing Gln 405 410 415 Ser Val Wing Lys Lys Glu Ser He Ser Val 420 425 < 210 > 425 < 211 > 1461 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1438) < 223 > RXA00623 ? ^ - < 400 > 425 ttt.aagcttc gtcggcaacg atcac, accac gttaaattte gaccatcaat gacggtggcc 60 ttttttggc gaatccccaa aaaggtcgaa gaggaagttc atg gat tea aac aac 115 Met Asp Ser Asn Thr 1 5 gaa tet tea agt gtt gag gtc aaa aac gaa f att aaa gtt caa aag 163 Glu Being Ser Val Glu Val Lys Asn Glu His He Lys Val Gln Lys 10 15 20 ccg aag aag aac gac cgc act f tgg etc tac att gcg gtc att ate 211 Pro Pro Lys Lys Asp Arg Thr His Trp Leu Tyr He Wing Val He He 25 30 35 gca ttg att ggc ggt att acc cta ggc ctg att tea ccg gag ttg ggc 259 Ala Leu He Gly Gly He Thr Leu Gly Leu He Ser Pro Glu Leu Gly 40 45 50 aaa gaa ttc aag att ttg ggc acc atg ttt gtg tcc ttg ate aag atg 307 Lys Glu Phe Lys He Leu Gly Thr Met Phe Val Ser Leu He Lys Met 55 60 65 att ate gct cca gtt att ttc tgc acc ate gtc ate gga ate ggt tea 355 He He Wing Pro Val He Phe Cys Thr He Val He Gly He Gly Ser 70 75 80 85 gtc aag gca gcg gca here gtc gga cgc gct ggt ggc ate gcc ctt gcg 403 Val Lys Wing Wing Thr Wing Val Gly Arg Wing Gly Gly He Wing Wing Leu 90 95 100 tac ttc tetc tc tc acc here tc gc etc gca gtt gcc ctg cta gtc 451 Tyr Phe He Thr Met Ser Thr Phe Ala Leu Wing Val Gly Leu Leu Val 105 110 115 ggt aac ttc ate cag cca ggt age gga ctg aac ate ate gtt gat gaa 499 Gly Asn Phe He Gln Pro Gly Ser Gly Leu Asn He Ser Val Asp Glu 120 125 130 gaa tet tea tcc gcc tcc here gag age age ect gaa gga etc ttg gga 547 Glu Being Ser Phe Wing Being Thr Glu Being Pro Glu Gly Leu Leu Gly 135 140 145 ttc ate f tcg ate ate ect gaa acg ttc ttc tet gca ttt act gat 595 Phe He His Ser He He Pro Pro Glu Thr Phe Phe Ser Ala Phe Thr Asp 150 155 160 165 ggt tcg gtg ctg cag gta ctg ttc ate gcc. tie etc gtg ggc ttt gca 643 Gly Ser Val Leu Gln Val Leu Phe He Wing He Leu Val Gly Phe Wing 170 175 180 gct cag tcg atg ggt gaa aag gga cag ccc ate ctt gat ttc gta tcc 691 Wing Gln Ser Met Gly Glu Lys Gly Gln Pro He Leu Asp Phe Val Ser 185 190 195 cat ctg cag aag etc ate ttc aag att ttg aac tgg att ctg tgg etc 739 His Leu Gln Lys Leu He Phe Lys He Leu Asn Trp He Leu Trp Leu 200 205 210 gcc cca gtc ggt gca ttc ggt gca atg gcc ggc gtc gtt ggc gaa here 787 Wing Pro Val Gly Wing Phe Gly Wing Wing Met Wing Val Val Gly Glu Thr 215 220 225 ggc ttt gat gcc gtt gtt cag etc ggt att ttg ate gcc etc ttt tac 835 Gly Phe Asp Ala Val Val Gln Leu Gly He Leu He Leu Ala Phe Tyr 230 235 240 245 gtc acc tgc gtg ate ttc ate ttt ggc gtg ctg ggc gcc gta ctg aag 883 Val Thr Cys Val He Phe He Phe Gly Val Leu Gly Ala Val Leu Lys 250 255 260 gtg ttc acc ggc gtg aat ate ttc aag ctg gtc aag tac ctt gcc aag 931 Val Phe Thr Gly Val Asn He Phe Lys Leu Val Lys Tyr Leu Wing Lys 265 270 275 gaa ttc ctg ctg ate ttt gct acc tet tet gaa tet gcc ttg cea 979 Glu Phe Leu Leu He Phe Wing Thr Ser Ser Ser Glu Ser Ala Leu Pro 280 285 290 aac etc atg cgc aag atg gaa f ate ggt gtg gct aaa cca acc gtc 1027 Asn Leu Met Arg Lys Met Glu His He Gly Val Wing Lys Pro Thr Val 295 300 305 gga ate gtg gtc cca acc ggc tat tcc ttc aac ttg gac ggc acc gca 1075 Gly He Val Val Pro Thr Gly Tyr Ser Phe Asn Leu Asp Gly Thr Wing 310 315 320 325 att tac etc acc atg gca tet ate ttc att gcc gac gcg atg aat atg 1123 He Tyr Leu Thr Met Wing Be He Phe He Wing Asp Wing Met Asn Met 330 335 340 ccg atg age etc ggc gag cag gtc ggt ctg ctt gtc ttc atg ate ate 1171 Pro Met Leu Gly Glu Gln Val Gly Leu Leu Val Phe Met He He 345 350 355 gca tcc aag ggc gct gct ggt gtc tcg ggt gcc ggt att gca acg ttg 1219 Wing Be Lys Gly Wing Wing Gly Val Ser Gly Wing Gly Wing Thr Leu 360 365 370 gct gcc gt gt tt tea drops cgc cca gaa ctt ctg drops ggc gtt gac 1267 Ala Ala Gly Leu Ser Ser His Arg Pro Glu Leu Leu His Gly Val Asp 375 380 385 gtg att gtg ggc ate gat aaa ttc atg tet gaa gcc cgc gca cta acc 1315 Val He Val Gly He Asp Lys Phe Met Ser Glu Ala Arg Ala Leu Thr 390 395 400 405 aac ttc gcc gga aac tcc gtg gca here ctg ctg gtc ggc aag tgg act 1363 Asn Phe Ala Gly Asn Ser Val Ala Thr Leu Leu Val Gly Lys Trp Thr 410 415 420 ggc acc gtg gac atg aac ca gtc cat gac gtt ttg aat gga aaa tet 1411 Gly Thr Val Asp Met Asn Gln Val His Asp Val Leu Asn Gly Lys Ser 425 430 435 cca ttt gtg gag tta gaa gaa gac drops tagttttcaa caggacgaca 1458 Pro Phe Val Glu Leu Glu Glu Asp His 440 445 acg 1461 < 210 > 426 < 211 > 446 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 426 Met Asp Being Asn Thr Glu Being Ser Val Valys Asn Glu His 1 5 10 15 He Lys Val Gln Lys Pro Pro Lys Lys Asp Arg Thr His Trp Leu Tyr 20 25 30 He Wing Val He He Wing Wing Leu He Gly Gly He Thr Leu Gly Leu He 35 40 45 Ser Pro Glu Leu Gly Lys Glu Phe Lys He Leu Gly Thr Met Phe Val 50 55 60 Ser Leu He Lys Met He He Wing Pro Val He Phe Cys Thr He Val 65 70 75 80 He Gl.y He Gly Ser Val Lys Ala Ala Ala Thr Val Gly Arg Ala Gly 85 90 95 Gly He Ala Ala Leu Ala Tyr Phe He Thr Met Ser Thr Phe Ala Leu Ala 100 105 110 Val Gly Leu Leu Val Gly Asn Phe He Gln Pro Gly Ser Gly Leu Asn 115 120 125 He Ser Val Asp Glu Glu Ser Ser Phe Ala Ser Thr Glu Ser Ser Pro L? l-? , 130 135 140 Glu Gly Leu Leu Gly Phe He H His Ser He He Pro Glu Thr Phe Phe 145 150 155 160 Be Ala Phe Thr Asp Gly Ser Val Leu Gln Val Leu Phe He Ala He 165 170 175 Leu Val Gly Phe Ala Ala Gln Being Met Gly Glu Lys Gly Gln Pro He 180 185 190 Leu Asp Phe Val Being His Leu Gln Lys Leu He Phe Lys He Leu Asn 195 200 205 • Trp He Leu Trp Leu Wing Pro Val Gly Wing Phe Gly Wing Met Wing Gly 210 215 220 Val Val Gly Glu Thr Gly Phe Asp Wing Val Val Gln Leu Gly He Leu 225 230 235 240 He Leu Wing Phe Tyr Val Thr Cys Val He Phe He Phe Gly Val Leu 245 250 255 Gly Wing Val Leu Lys Val Phe Thr Gly Val Asn He Phe Lys Leu Val 260 265 270 Lys Tyr Leu Wing Lys Glu Phe Leu Leu He Phe Wing Thr Ser Ser Ser 275 280 285 Glu Ser Wing Leu Pro Asn Leu Met Arg Lys Met Glu His He Gly Val 290 10 295 300 Wing Lys Pro Thr Val Gly He Val Val Pro Thr Gly Tyr Ser Phe Asn 305 310 315 320 Leu Asp Gly Thr Ala He Tyr Leu Thr Met Ala Ser He Phe He Ala 325 330 335 Asp Ala Met Met Met Met Met Ser Leu Gly Gllu Gln Val Gly Leu Leu 340 345 350 Val Phe Met He He Wing Being Lys Gly Wing Wing Gly Val Ser Gly Wing 355 360 365 Gly He Wing Thr Leu Wing Wing Gly Leu Ser Being His Arg Pro Glu Leu 370 375 380 Leu His Gly Val Asp Val He Val Gly He Asp Lys Phe Met Ser Glu 15 385 390 395 400 Wing Arg Ala Leu Thr Asn Phe Wing Gly Asn Ser Val Wing Thr Leu Leu 405 410 415 Val Gly Lys Trp Thr Gly Thr Val Asp Met Asn Gln Val His Asp Val 420 425 430 Leu Asn Gly Lys Ser Pro Phe Val Glu Leu Glu Glu Asp His 435 440 445 < 210 > 427 • < 211 > 620 < 212 > DNA < 213 > Corynebacterium glutamicum 20 < 220 > < 221 > CDS < 222 > (55) .. (597) < 223 > RXA01584 < 400 > 427 ccaccccctt ccccgctacg cgccataccg gcttgggcgg gcatcggatc act gtg 57 Val 1 gtg ttt ttg ggc gca ctt etc ggc gcc gta ate atg ggc ggg ttt tat 105 Val Phe Leu Gly Ala Leu Leu Gly Ala Val He Met Gly Gly Phe Tyr 25 5 10 15 cca gca ttc att ca gcc gg gga tcc here gtg gt ggc ggc ggc falls gtg 153 Pro Wing Phe He Gln Wing Gly Ser Thr Val Phe Gly Gly Gly His Val 20 25 30 gtt ttg cca ctg ctg gaa aag etc gtt gtt gcg ccc ggt ttt att aaa 201 Val Leu Pro Leu Leu Glu Lys Leu Val Val Wing Pro Gly Phe He Lys 35 40 45 gaa acc gac ttc cta tcc ggc tac tcc gca gcg cag gca gtg ect ggc 249 Glu Thr Asp Phe Leu Ser Gly Tyr Ser Ala Ala Gln Ala Val Pro Gly • 50 55 60 65 ccc atg ttc age tcc gcc age tac etc ggc gcc gcc ate gcc gtc ate 297 Pro Met Phe Ser Phe Wing Being Tyr Leu Gly Wing He Tyr Gly Gly He 70 75 80 ggt ggt gca gtg ctg gcc age ctg gcg ate ttc tcc ccc gcc gca etc 345 Gly Gly Ala Val Leu Ala Ser Leu Ala He Phe Phe Pro Ala Ala Leu 85 90 95 ttg age ate age gga atg tac ttt tgg gga cgc tgg cga aaa gca ccg 393 Leu Ser Be Gly Met Tyr Phe Trp Gly Arg Trp Arg Lys Wing Pro 100 105 110 cgc ate ca gca gca gc gc gc gc gcg ct ggg gtg ggg ctt 441 Arg He Gln Ala Wing Val Thr Gly He Asn Wing Gly Val Val Gly Leu 10 115 120 125 ttg ggc gca gcg etc tac gat ccc gta ttc acc fall ggc ate acc age 489 Leu Gly Ala Ala Leu Tyr Asp Pro Val Phe Thr His Gly He Thr Ser 130 135 140 145 • gtt tcc gca tta gct ate gca acg gtg tgt tgg ctg ggg cta gcc drops 537 Val Ser Ala Leu Ala He Ala Thr Val Cys Trp Leu Gly Leu Ala His 150 155 160 tgg aaa att ccg ccg tgg gcc ate gcc gcg ggt gcg gcc ctt gca ggc 585 Trp Lys He Pro Pro Trp Ala He Ala Ala Gly Ala Ala Leu Wing Gly 165 170 175 tgg gtc ttg ctt tagaaaacgc t: cagacccaa acc 620 Trp Val Leu Leu 15 180 < 210 > 428 < 211 > 181 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 428 • Val Val Phe Leu Gly Ala Leu Leu Gly Ala Val He Met Gly Gly Phe 1 5 10 15 Tyr Pro Wing Phe He Gln Wing Gly Ser Thr Val Phe Gly Gly Gly His 20 25 30 20 Val Val Leu Pro Leu Leu Glu Lys Leu Val Val Ala Pro Gly Phe He 35 40 45 Lys Glu Thr Asp Phe Leu Ser Gly Tyr Be Ala Ala Gln Ala Val Pro 50 55 60 Gly Pro Met Phe Ser Phe Ala Ser Tyr Leu Gly Ala He Tyr Gly Gly 65 70 75 80 He Gly Gly Ala Val Leu Ala Ser Leu Ala He Phe Phe Pro Wing Wing 85 90 95 Leu Leu Ser He Gly Met Tyr Phe Trp Gly Arg Trp Arg Lys Wing 100 105 110 Pro Arg He Gln Wing Wing Val Thr Gly He Asn Ala Gly Val Val Gly 115 120 125 25 Leu Leu Gly Ala Ala Leu Tyr Asp Pro Val Phe Thr His Gly He Thr 130 135 140 Ser Val Ser Ala Leu Ala He Ala Thr Val Cys Trp Leu Gly Leu Ala 145 150 155 160 His Trp Lys He Pro Pro Trp Wing He Wing Wing Gly Wing Wing Leu Wing 165 170 175 Gly Trp Val Leu Leu 180 < 210 > 429 < 211 > 813 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (790) < 223 > RXA00852 < 400 > 429 agatcacegt catggtcata atcgccgctg gagttcatgc agcattccct gacatccgta 60 10 agaaatagtt ccaacccact ttteetcaga attgcagttc atg ccc gag ate att 115 Met Pro Glu He He 1 5 ttt gac aac act gaa gta cgc tac gat gac tcg etc att tta gag ccc 163 • Phe Asp Asn Thr Glu Val Arg Tyr Asp Asp Ser Leu He Leu Glu Pro 10 15 20 cta tcg tta aaa ctg here gaa cag cgc att ggc ate ate ggg gct aac 211 Leu Ser Leu Lys Leu Thr Glu Gln Arg He Gly He He Gly Ala Asn 25 30 35 ggc ggt gga aaa tcc acg etc tie aga atg ate aat ggt etc ggc gaa 259 Gly Gly Gly Lys Ser Thr Leu He Arg Met He Asn Gly Leu Gly Glu 40 45 50 15 cca acc here ggg cgt gtt cta gtt gat ggc ctt gac gtc tcg cat aka 307 Pro Thr Thr Gly Arg Val Leu Val Asp Gly Leu Asp Val Ser His Ser 55 60 65 gga cgg gaa gtt cgc aag aag gtt gga ttt gtc ttc tet gac gct gaa 355 Gly Arg Glu Val Arg Lys Lys Val Gly Phe Val Phe Ser Asp Ala Glu 70 75 80 85 aac cag ate gtg atg cca act gtg cgt gag gat att gcc ttc tcg ctt 403 Asn Gln He Val Met Pro Thr Val Arg Glu Asp He Ala Phe Ser Leu 90 95 100 • cgc cgg falls aaa atg cca cgc gct gaa aag gcg caa cgt gtc gac gag 451 Arg Arg His Lys Met Pro Arg Ala Glu Lys Ala Gln Arg Val Asp Glu 105 110 115 20 atg atg gcg cga ttc aac ttg age gag cat gca gat ca TEA ccg drops 499 Met Met Ala Arg Phe Asn Leu Ser Glu His Ala Asp Gln Ser Pro His 120 125 130 acc cta aka ggt ggt caa aag cag ttg tta gcg ctg gct gta gca ctg 547 Thr Leu Ser Gly Gly Gln Lys Gln Leu Leu Ala Leu Ala Ala Val Leu 135 140 145 att ttg gag cca gaa gtg ate ate gct gat gag ccc act ace ctg ctg 595 He Leu Glu Pro Glu Val He He Wing Asp Glu Pro Thr Thr Leu Leu 150 155 160 165 gat ctg cgc aat agg ctg atg ate aaa gac gtg ttc aat aaa etc gag 643 Asp Leu Arg Asn Arg Leu Met He Lys Asp Val Phe Asn Lys Leu Glu 170 175 180 25 cag tta caa ate gtt gtc age cat gat tta gat ttc etc age gat ttt 691 . ", - * * • • • • • • • • • • • Gln Gln Leu He Val Val Ser His Asp Leu Asp Phe Leu Ser Asp Phe 185 190 195 gag cgg gtc att tgc ate aat gat cat aaa ate gct gct gat ggc ect 739 Glu Arg Val He Cys He Asn Asp His Lys He Ala Ala Asp Gly Pro 200 205 210 ccg caa aag aka att gac ctg tac gta tcg ctt atg gcg gaa ect gcg 787 Pro Gln Lys Ser He Asp Leu Tyr Val Ser Leu Met Ala Glu Pro Ala 215 220 225 aaa tgaacagtat tcctttaggt ttt 813 Lys 230 < 210 > 430 < 211 > 230 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 430 Met Pro Glu He He Phe Asp Asn Thr Glu Val Arg Tyr Asp Asp Ser 1 5 10 15 Leu He Leu Glu Pro Leu Ser Leu Lys Leu Thr Glu Gln Arg He Gly 20 25 30 He He Gly Wing Asn Gly Gly Gly Lys Ser Thr Leu He Arg Met He 35 40 45 Asn Gly Leu Gly Glu Pro Thr Thr Gly Arg Val Leu Val Asp Gly Leu 50 55 60 Asp Val Ser Ser Gly Arg Glu Val Arg Lys Lys Val Gly Phe Val 65 70 75 80 Phe Ser Asp Ala Glu Asn Gln He Val Met Pro Thr Val Arg Glu Asp 85 90 95 He Ala Phe Ser Leu Arg Arg His Lys Met Pro Arg Ala Glu Lys Ala 100 105 110 Gln Arg Val Asp Glu Met Met Ala Arg Phe Asn Leu Ser Glu His Wing 115 120 125 Asp Gln Ser Pro His Thr Leu Ser Gly Gly Gln Lys Gln Leu Leu Wing 130 135 140 Leu Ala Ala Val Leu He Leu Glu Pro Glu Val He He Wing Asp Glu 145 150 155 160 Pro Thr Thu Leu Leu Asu Leu Arg Asn Arg Leu Met He Lys Asp Val 165 170 175 Phe Asn Lys Leu Glu Gln Gln Leu He Val Val Ser His Asp Leu Asp 180 185 190 Phe Leu Ser Asp Phe Glu Arg Val He Cys He Asn Asp His Lys He 195 200 205 Wing Wing Asp Gly Pro Pro Gln Lys Ser He Asp Leu Tyr Val Ser Leu 210 215 220 Met Wing Glu Pro Wing Lys 225 230 < 210 > 431 < 211 > 1269 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101); 1246) < 223 > RXA00690 < 400 > 431 atggatcatt ggactcacac tggctgtcat ttccttggtt tcgcgtctg ctgtggcggc: 60 gtgggcgatt cgtcgttcag aggtccaggg ttaaagette gtg aaa tgg att gag 115 Val Lys Trp He Glu 1 5 cga tat gtg ctg ccc cgg cgg atg gtt cat ccc tgg gcg tgg tgg gtg 163 Arg Tyr Val Leu Ser Arg Arg Met Val His Pro Trp Wing Trp Trp Val • 10 15 20 tgg gcg ttg ggt att gct ggt tgt gcc age atg acc aac aat ect tat 211 Trp Wing Leu Gly He Wing Gly Cys Wing Being Met Thr Asn Asn Pro Tyr 25 30 35 att ttg gcg etc act ttt gcc acg ttg tgt ttt gtg gtg ttt aac cgt 259 He Leu Wing Leu Thr Phe Wing Thr Leu Cys Phe Val Val Phe Asn Arg 40 45 50 cgt ggg tea tcg ccg tgg tcg cgt gct tcc ccg ate tat ttg atg tie 307 Arg Gly Ser Ser Pro Trp Be Arg Wing Phe Pro He Tyr Leu Met He 55 60 65 gcg ggt tgg etc gtg gtg tac cgg ttg gtc atg fall att gtg gtg gga 355 10 Wing Gly Trp Leu Val Val Tyr Arg Leu Val Met His He Val Val Gly 70 75 80 85 gca aaa att ggc acc att gaa ctg ttt cgg ate ccg ccg gtg cag ttg 403 Ala Lys He Gly Thr He Glu Leu Phe Arg He Pro Pro Val Gln Leu 90 95 100 ccg gaa tgg gct gcg ggt ate drops gtg ttt ggc acg gtg tat etc gag 451 Pro Glu Trp Ala Ala Gly He His Val Phe Gly Thr Val Tyr Leu Glu 105 110 115 ggt ctg ate ate gcg acg acg ca ggc tta acg ctt gga acg ateg 499 Gly Leu He He Wing Thr Thr Gln Gly Leu Thr Leu Gly Thr Met He 120 125 130 gtg gcg gtg ggt gct gcg aac tet ttg gcg gat ccc aag aag ctg etc 547 . "Val Ala Val Gly Ala Ala Asn Ser Leu Ala Asp Pro Lys Lys Leu Leu 135 140 145 aaa tcg ttg ect ggc gca ttg ggc gaa ctg gga act gcg gtg gtc ate 595 Lys Ser Leu Pro Gly Wing Leu Gly Glu Leu Gly Thr Wing Val Val He 150 155 160 165 ggt att tcc att gca ect cag atg gct gag tcg gcg ttc cgc att aat 643 Gly He Ser He Wing Pro Gln Met Wing Glu Wing Wing Phe Arg He Asn 170 175 180 cgt gca cga acc ttg cgt ggt gat gat gcc aaa ggt gtt cgt ggt ttc 691 • Arg Ala Arg Thr Leu Arg Gly Asp Asp Ala Lys Gly Val Arg Gly Phe 185 190 195 gcg cgg att ttg atg ccg gtt ttc cag gac act ttg gat agg tet ttg 739 ~ r. Wing Arg He Leu Met Pro Val Phe Gln Asp Thr Leu Asp Arg Ser Leu 200 205 210 gcc ctg gct aat tcc atg gat gcc cgt ggt tat ggc agg cag gct cat 787 Ala Leu Ala Asn Ser Met Asp Wing Arg Gly Tyr Gly Arg Gln Wing His 215 220 225 gta tcc aaa ttc caà cag cgt gtg acc tet att ttt ggt gca ttc gga 835 Val Ser Lys Phe Gln Gln Arg Val Thr Ser He Phe Gly Wing Phe Gly 230 235 240 245 ata etc ggc gtg acc gtt ggt ctg ttt gtg gtc tta gat gca tea tea 883 He Leu Gly Val Thr Val Gly Leu Phe Val Val Leu Asp Ala Ser Ser 250 255 260 ccg atg ttc gtt gcc gtt ccg gtg ttt att acc ggc gtg ggc ttc ttg 931 9S Pro Met Phe Val Wing Val Pro Val Phe He Thr Gly Val Gly Phe Leu 265 270 275 ate att tcg ttg gtc gtt gct tea cat aga aaa here tcc acc act ttt 979 He He Ser Leu Val Val Ala Ser His Arg Lys Thr Ser Thr Thr Phe 280 285 290 gat cag ttg ect tgg ggt gct gcg gaa tgg ctt gtg tgc ate here ggt 1027 Asp Gln Leu Pro Trp Gly Wing Wing Glu Trp Leu Val Cys He Thr Gly 295 300 305 gtg att ccg ctg etc atg gct gcg ctg here cga tac ctt gat cca ggt 1075 Val He Pro Leu Leu Met Ala Ala Leu Thr Arg Tyr Leu Asp Pro Gly 310 315 320 325 tcc atg ate acc acc tgg gtt ect ttg cat atg cca gac acc gtt ccg 1123 Ser Met He Thr Thr Trp Val Pro Leu His Met Pro Asp Thr Val Pro 330 335 340 ttg etc gtt gtg gca gtt ctt gtt gtg gcg acg atg cca gga ttc ttg 1171 Leu Leu Val Val Ala Gly Leu Val Val Ala Thr Met Pro Gly Phe Leu 345 350 355 acg ccc cgc ttg ccg aag aac aaa gtg agg gtc aag cgt cga aaa gca 1219 Thr Pro Arg Leu Pro Lys Asn Lys Val Arg Val Lys Arg Arg Lys Wing 360 365 370 ata aat age cca gaa agg gcc gaa gtt taatgagtgc tccttttagc 1266 He Asn Ser Pro Glu Arg Ala Glu Val 375 380 gcg 1269 < 210 > 432 < 211 > 382 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 432 Val Lys Trp He Glu Arg Tyr Val Leu Ser Arg Arg Met Val His Pro 1 5 10 15 Trp Wing Trp Trp Val Trp Wing Leu Gly He Wing Gly Cys Wing Being Met 20 25 30 Thr Asn Asn Pro Tyr He Leu Wing Leu Thr Phe Ala Thr Leu Cys Phe 35 40 45 Val Val Phe Asn Arg Arg Gly Ser Ser Pro Trp Ser Arg Ala Phe Pro 50 55 60 He Tyr Leu Met He Wing Gly Trp Leu Val Val Tyr Arg Leu Val Met 65 70 75 80 His He Val Val Gly Wing Lys He Gly Thr He Glu Leu Phe Arg He 85 90 95 Pro Pro Val Gln Leu Pro Glu Trp Wing Wing Gly He His Val Phe Gly 100 105 110 Thr Val Tyr Leu Glu Gly Leu He He Wing Thr Thr Gln Gly Leu Thr 115 120 125 Leu Gly Thr Met He Val Wing Val Gly Wing Wing Asn Ser Leu Wing Asp 130 135 140 Pro Lys Lys Leu Leu Lys Ser Leu Pro Gly Wing Leu Gly Glu Leu Gly 145 150 155 160 Thr Wing Val Val He Gly I Am Being Wing Pro Gln Met Wing Glu Being 165 170 175 Wing Phe Arg He Asn Arg Wing Arg Thr Leu Arg Gly Asp Asp Wing Lys 180 185 190 Gly Val Arg Gly Phe Wing Arg He Leu Met Pro Val Phe Gln Asp Thr 195 200 205 Leu Asp A rg Ser Leu Ala Leu Ala Asn Ser Met Asp Ala Arg Gly Tyr ^ ^ ^^^^ 210 215 220 Gly Arg Gln Ala His Val Ser Lys Phe Gln Gln Arg Val Thr Ser He 225 230 235 240 Phe Gly Wing Phe Gly He Leu Gly Val Thr Val Gly Leu Phe Val Val 245 250 255 Leu Asp Wing Ser Ser Pro Met Phe Val Wing Val Pro Val Phe He Thr 260 265 270 Gly Val Gly Phe Leu He He Ser Val Leu Val Leu Ser His Arg Lys 275 280 285 Thr Ser Thr Thr Phe Asp Gln Leu Pro Trp Gly Ala Wing Glu Trp Leu 290 295 300 Val Cys He Thr Gly Val He Pro Leu Leu Met Ala Ala Leu Thr Arg 305 310 315 320 Tyr Leu Asp Pro Gly Ser Met He Thr Thr Trp Val Pro Leu His Met 325 330 335 Pro Asp Thr Val Pro Leu Leu Val Val Wing Gly Leu Val Val Wing Thr 340 345 350 Met Pro Gly Phe Leu Thr Pro Arg Leu Pro Lys Asn Lys Val Arg Val 355 360 365 Lys Arg Arg Lys Wing He Asn Ser Pro Glu Arg Wing Glu Val 370 375 380 < 210 > 433 < 211 > 876 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (853) < 223 > RXA00827 < 400 > 433 tgegtgaatt aacagacaac ggaatcagea ttgtgtcagt aacccatgat cctgatttca 60 tcgcagcgct gggcgatcac cacattgagg tgagcgcgaa gtg aac ctg ctg ate 115 Val Asn Leu Leu He 1 5 aaa att aat ccc gtc acc cgc ate ate gcg ttg atg gta ctg ac ac 163 Lys He Asn Pro Val Thr Arg He He Wing Leu Met Val Leu Thr Thr 10 15 20 ccg ttg ctg ctg agt ttg gat gtg atg tcg gca gcg ate gcg ctg gtg 211 Pro Leu Leu Leu Ser Leu Asp Val Met Be Wing Wing He Wing Leu Val 25 30 35 gca acc att att ctg gca cca ttt gcc ggc gtg acc tgg aag atg ctg 259 Wing Thr He He Leu Wing Pro Phe Wing Gly Val Thr Trp Lys Met Leu 40 45 50 ctg aaa cgt ggc tgg atg ctg ttc etc atg gca ccg gtg gct gca tta 307 Leu Lys Arg Gly Trp Met Leu Phe Leu Met Wing Pro Val Wing Ala Leu 55 60 65 tcc atg gcg ctt tat ggc agg ccg gat gga aaa gag tac ttt age ttc 355 Ser Met Ala Leu Tyr Gly Arg Pro Asp Gly Lys Glu Tyr Phe Ser Phe 70 75 80 85 ctg etc att falls gtc act gat aat tea ctg gct ttg gct gct gcc att 403 Leu Leu He His Val Thr Asp Asn Ser Leu Ala Leu Ala Wing Wing He 90 95 100 ggg ctg cgt gtt ctg gcg att ggt ctg ccc gtt gtg gtg ctg att gct 451 Gly Leu Arg Val Leu Wing He Gly Leu Pro Val Val Val Leu He Wing 105 110 115 cgc att gat ccc acc gac ctg ggc gat ggt ttg gcg cag ctg etc aaa 499 Arg He Asp Pro Thr Asp Leu Gly Asp Gly Leu Wing Gln Leu Leu Lys 120 125 130 ctg ect gaa agg ttt gtc ate ggt gct gct gca gga age cga ctg atg 547 Leu Pro Glu Arg Phe Val He Gly Ala Val Ala Gly Ser Arg Leu Met 135 140 145 acg ctt ttt cgg gaa gat tgg tac tcc atg tcc agg gca agg cgt gcc 595 • Thr Leu Phe Arg Glu Asp Trp Tyr Ser Met Ser Arg Ala Arg Arg Ala 150 155 160 165 cgc gga att gct gat cag ggc aag ate aag falls ttt ttc acc atg act 643 Arg Gly He Wing Asp Gln Gly Lys He Lys His Phe Phe Thr Met Thr 170 175 180 ttt ggt ttg ttg gtg etc tcg ctt cgc cgt gga tcc aag ctt gca acg 691 Phe Gly Leu Leu Val Leu Ser Leu Arg Arg Gly Ser Lys Leu Ala Thr 185 190 195 gcg atg gaa gca cgc ggt ttt ggt cgc acg act ggc cgc acc tgg gca 739 Wing Met Glu Wing Arg Gly Phe Gly Arg Thr Thr Gly Arg Thr Trp Wing 200 205 210 agg gaa tcc acc gtc ggc gcg cgc gat ctg gtg etc ate ttg gtg tgt 787 10 Arg Glu Ser Thr Val Gly Wing Arg Asp Leu Val Leu He Leu Val Cys 215 220 225 gct gcc att tcc gcg ate gct cta acc gtg tcc att cag act ggt ttc 835 • Wing Wing Be Wing Wing Wing Leu Thr Val Ser He Gln Thr Gly Phe 230 235 240 245 ttt aag ttc ttg ggc here tgaticacagt tttaattgat gga 876 Phe Lys Phe Leu Gly Thr 250 < 210 > 434 < 211 > 251 < 212 > PRT 15 < 213 > Corynebacterium glutamicum < 400 > 434 Val Asn Leu Leu He Lys He Asn Pro Val Thr Arg He He Wing Leu 1 5 10 15 Met Val Leu Thr Thr Pro Leu Leu Leu Ser Leu Asp Val Met Ser Wing 20 25 30 Wing He Wing Wing Leu Val Wing Thr He He Leu Wing Pro Phe Wing Wing Val • 35 40 45 Thr Trp Lys Met Leu Leu Lys Arg Gly Trp Met Leu Phe Leu Met Wing 50 55 60 Pro Val Wing Wing Leu Ser Met Wing Leu Tyr Gly Arg Pro Asp Gly Lys 20 65 70 75 80 Glu Tyr Phe Ser Phe Leu Leu He His Val Thr Asp Asn Ser Leu Wing 85 90 95 Leu Wing Wing Wing He Gly Leu Arg Val Leu Wing He Gly Leu Pro Val 100 105 110 Val Val Leu He Wing Arg He Asp Pro Thr Asp Leu Gly Asp Gly Leu 115 120 125 Wing Gln Leu Leu Lys Leu Pro Glu Arg Phe Val He Gly Wing Val Wing 130 135 140 Gly Ser Arg Leu Met Thr Leu Phe Arg Glu Asp Trp Tyr Ser Met Ser 145 150 155 160 Arg Ala Arg Arg Wing Arg Gly He Wing Asp Gln Gly Lys He Lys His 25 165 170 175 Phe Phe Thr Met Thr Phe Gly Leu Leu Val Leu Ser Leu Arg Arg Gly 180 185 190 Ser Lys Leu Wing Thr Wing Met Glu Wing Arg Gly Phe Gly Arg Thr Thr 195 200 2 05 Gly Arg Thr Trp Wing Arg Glu Ser Thr Val Gly Wing Arg Asp Leu Val 210 215 220 Leu He Leu Val Cys Wing Wing He Wing Wing He Wing Leu Thr Val Ser 225 230 235 240 He Gln Thr Gly Phe Phe Lys Phe Leu Gly Thr 245 250 < 210 > 435 < 211 > 732 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (709) < 223 > RXA00851 < 400 > 435 ttg; agcgggt, catttgcatc aatga'tcat; a aa; atcgctgc tgatggccct < ccgcaaaagt 60 ccattgacct, gtacigtatieg cttatiggcgg aacctgicgaa atg aac agt att ect 115 Met Asn Ser He Pro 1 5 tta ggt ttt tac gtc gat aag caat tet gtt gt cat tet ttt ect gct 163 Leu Gly Phe Tyr Val Asp Lys Gln Ser Val Val His Ser Phe Pro Wing 10 15 20 ttg tgg aaa ttc cca ctt ctg ctg ttt ttc ate ate ggc ggc tcc ate 211 Leu Trp Lys Phe Pro Leu Leu Leu Phe Phe He He Gly Gly Be He 25 30 35 gcg gct tet acc ccg gtt cat ggg ttg att ttg gtg ggg att gca gtg 259 Ala Ala Ser Thr Pro Val His Gly Leu He Leu Val Gly He Ala Val 40 45 50 gtg ttt tac gtg ctg gcg aag att ccg ctg aag gtc gcg tgg gag cag 307 Val Phe Tyr Val Leu Wing Lys He Pro Leu Lys Val Wing Trp Glu Gln 55 60 65 ttg tgg cg gtg ctg ccg att ttg ate atg etc ggt gcg ttt cagg tgg 355 Leu Trp Pro Val Leu Pro He Leu He Met Leu Gly Ala Phe Gln Trp 70 75 80 85 tgg cag cgc ggc ttt gat ttc gcg gca ac here gtg etc acg ctg ttt 403 Trp Gln Arg Gly Phe Asp Phe Wing Wing Thr Thr Val Leu Thr Leu Phe 90 95 100 tcc gcg gtg atg gcc gcc atg ttg ttg acg ttg acc acg cgg ttg gaa 451 Be Wing Val Met Wing Wing Met Leu Leu Thr Leu Thr Thr Arg Leu Glu 105 110 115 gcg etc atg aat gca gtt gag cgg atg ttg cag ect ttt gca cgt ttt 499 Wing Leu Met Asn Wing Val Glu Arg Met Leu Gln Pro Phe Wing Arg Phe 120 125 130 ggc ctg cca gta gag acg ate acc ttg gct att tet etc acg att cgg 547 Gly Leu Pro Val Glu Thr He Thr Leu Wing He Ser Leu Thr He Arg 135 140 145 etc att ccg ctg cata tta gcc acg gtg aag gaa gtc etc gat gcc cgt 595 Leu He Pro Leu Gln Leu Ala Thr Val Lys Glu Val Leu Asp Ala Arg 150 155 160 165 aaa gct ggt ggt ggt ttt tet ate gcc gcg ttt ggc acg ect gtg 643 Lys Wing Arg Gly Wing Gly Phe Ser Wing Wing Wing Phe Gly Thr Pro Val 170 175 180 ate ate aga tea ata aag agg gcc cgc aat ate ggc gat gct ctt etc 691 He He Arg Be He Lys Arg Ala Arg Asn He Gly Asp Ala Leu Leu 185 190 195 gca cgt ggt gcc ggc gat taatttcttt caacacatag ca 732 Wing Arg Gly Wing Gly Asp 200 • < 210 > 436 < 211 > 203 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 436 Met Asn Ser He Pro Leu Gly Phe Tyr Val Asp Lys Gln Ser Val Val 1 5 10 15 His Ser Phe Pro Ala Leu Trp Lys Phe Pro Leu Leu Leu Phe Phe He 20 25 30 He Gly Gly Ser He Ala Wing Ser Thr Pro Val His Gly Leu He Leu 35 40 45 10 Val Gly He Wing Val Val Phe Tyr Val Leu Wing Lys He Pro Leu Lys 50 55 60 Val Wing Trp Glu Gln Leu Trp Pro Val Leu Pro He Leu He Met Leu • 65 70 75 80 Gly Wing Phe Gln Trp Trp Gln Arg Gly Phe Asp Phe Wing Wing Thr Thr 85 90 95 Val Leu Thr Leu Phe Ser Wing Val Met Wing Wing Met Leu Leu Thr Leu 100 105 110 Thr Thr Arg Leu Glu Wing Leu Met Asn Wing Val Glu Arg Met Leu Gln 115 120 125 Pro Phe Wing Arg Phe Gly Leu Pro Val Glu Thr He Thr Leu Wing He 15 130 135 140 Ser Leu Thr He Arg Leu He Pro Leu Gln Leu Wing Thr Val Lys Glu 145 150 155 160 Val Leu Asp Wing Arg Lys Wing Arg Gly Wing Gly Phe Ser Wing Wing 165 170 175 Phe Gly Thr Pro Val He He Arg Ser He Lys Arg Wing Arg Asn He 180 185 190 Gly Asp Wing Leu Leu Wing Arg Gly Wing Gly Asp 195 200 < 210 > 437 < 211 > 725 20 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (3) .. (6951 <223> RXS03220 <400> 437 cc atg ggc tta agg gaa att ttg tcc age aag tgg ctt gtg cgc ate 47 Met Gly Leu Arg Glu He Leu Ser Ser Lys Trp Leu Val Arg He 1 5 10 15 25 etc ctg gta ggt ate gga ttg ggt gtc gca cag cag ctg acc ggc ate 95 Leu Leu Val Gly He Gly Leu Gly Val Ala Gln Gln Leu Thr Gly He 20 25 30 aac tcc ate atg tac tac ggc cag gtt gtt etc att gag gct gt ttc 143 Asn Ser Met Met Tyr Tyr Gly Gln Val Val Leu He Glu Wing Gly Phe 35 40 45 tcc gag aat gca gct ctg ate gc aac gtg gcg cca gga gtg ate gca 191 Ser Glu Asn Ala Ala Leu He Ala Asn Val Ala Pro Gly Val He Ala 50 55 60 gtt gtc ggt gca ttc ate gca ctg tgg atg atg gat ggt ate aac cgc 239 • Val Val Gly Wing Phe He Wing Leu Trp Met Met Asp Gly He Asn Arg 65 70 75 cgt acc action etc att acc ggt tat tet etc acc acc att age fall gta 287 Arg Thr Thr Leu He Thr Gly Tyr Ser Leu Thr Thr He Ser His Val 80 85 90 95 ttg ate ggt ate gca tcc gta gca ttc cca gtc ggc gat ect ctt cgc 335 Leu He Gly He Wing Ser Val Wing Phe Pro Val Gly Asp Pro Leu Arg 100 105 110 ccc tac gtt ate ttg act ctg gtt gtg gtc ttc gtg gga tcc atg cag 383 Pro Tyr Val He Leu Thr Leu Val Val Val Phe Val Gly Ser Met Gin 115 120 125 acc ttc etc. aac gta gct acc ttc ccg 431 10 tgg gtt atg etc tet gag etc. Thr Phe Leu Asn Val Wing Thr Trp Val Met Leu Ser Glu Leu Phe Pro 130 135 140 ctg gca atg cgc ggt ttc gca ate ggt ate tea gtg ttc ttc etc tgg 479 • Leu Wing Met Arg Gly Phe Wing He Gly He Ser Val Phe Phe Leu Trp 145 150 155 ate gca aac gcg ttc etc gga ttg ttc ttc cca acc ate atg gaa gca 527 He Wing Asn Wing Phe Leu Gly Leu Phe Phe Pro Thr He Met Glu Wing 160 165 170 175 gta gga gta cta acc acc ttc ttc atg ttc gcc gga ate ggt gtg gtt 575 Val Gly Leu Thr Gly Thr Phe Phe Met Phe Wing Gly He Gly Val Val 180 185 190 gcc ttg ate ttc ate tac acc cag gtt ect gaa act cgt 15 gga cgt acc 623 Ala Leu He Phe He Tyr Thr Gln Val Pro Glu Thr Arg Gly Arg Thr 195 200 205 ttg gag gag att gat gag gat gtt act tcc ggt gtc att ttc aac aag 671 Leu Glu Glu He Asp Glu Asp Val Thr Ser Gly Val He Phe Asn Lys 210 215 220 gac ate cga aaa gga aag gtg falls taaaaaccca gacac: tgcat agataaicacc 725 Asp He Arg Lys Gly Lys Val His 225 230 • < 210 > 438 < 211 > 231 < 212 > PRT 20 < 213 > Corynebacterium glutamicum < 400 > 438 Met Gly Leu Arg Glu He Leu Ser Ser Lys Trp Leu Val Arg He Leu 1 5 10 15 Leu Val Gly He Gly Leu Gly Val Wing Gln Gln Leu Thr Gly He Asn 20 25 30 Being He Met Tyr Tyr Gly Gln Val Val Leu He Glu Wing Gly Phe Ser 35 40 45 Glu Asn Ala Ala Leu He Ala Asn Val Ala Pro Gly Val He Wing Val 50 55 60 25 Val Gly Wing Phe He Wing Leu Trp Met Met Asp Gly He Asn Arg Arg 65 70 75 80 Thr Thr Leu He Thr Gly Tyr Ser Leu Thr Thr He Ser His Val Leu 85 90 95 He Gly He Wing Ser Val Wing Phe Pro Val Gly Asp Pro Leu Arg Pro 100 105 110 Tyr Val He Leu Thr Leu Val Val Val Phe Val Gly Ser Met Gln Thr 115 120 125 Phe Leu Asn Val Wing Thr Trp Val Met Leu Ser Glu Leu Phe Pro Leu 130 135 140 • Wing Met Arg Gly Phe Wing He Gly He Ser Val Phe Phe Leu Trp He 145 150 155 160 Wing Asn Wing Phe Leu Gly Leu Phe Phe Pro Thr He Met Glu Wing Val 165 170 175 Gly Leu Thr Gly Thr Phe Phe Met Phe Wing Gly He Gly Val Val Wing 180 185 190 Leu He Phe He Tyr Thr Gln Val Pro Glu Thr Arg Gly Arg Thr Leu 195 200 205 Glu Glu He Asp Glu Asp Val Thr Ser Gly Val He Phe Asn Lys Asp 210 215 220 He Arg Lys Gly Lys Val His 225 230 10 <; 210 > 439 < 211 > 408 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (385) < 223 > FRXA02762 < 400 > 439 15 ttcccagtcg < gcgatcct: t tt; gcctctac gttatettga etetggttgt < ggtcttcgtg 60 ggatccatgc; agacette: t caacggtagc tacctgggtt atg etc tet gag etc 115 Met Leu Ser Glu Leu 1 5 ttc ccg ctg gca atg cgc ggt ttc gca ate ggt ate tea gtg ttc ttc 163 Phe Pro Leu Wing Met Arg Gly Phe Wing He Gly He Ser Val Phe Phe 10 15 20 etc tgg ate gca aac gcg ttc etc gga ttg ttc ttc cca acc ate atg 211 • Leu Trp He Wing Asn Wing Phe Leu Gly Leu Phe Phe Pro Thr He Met 25 30 35 gaa gca gta gta cta acc gga acc ttc ttc atg ttc gcc gga ate ggt 259 Glu Wing Val Gly Leu Thr Gly Thr Phe Phe Met Phe Wing Gly He Gly 20 40 45 50 gtg gtt gcc ttg ate ttc ate tac acc cag gtt ect gaa act cgt gga 307 Val Val Ala Leu He Phe He Tyr Thr Gln Val Pro Glu Thr Arg Gly 55 60 65 cgt acc ttg gag gag att gat gag gat gtt act tcc ggt gtc att ttc 355 Arg Thr Leu Glu Glu He Asp Glu Asp Val Thr Ser Gly Val He Phe 70 75 80 85 aac aag gac ate cga aaa gga aag gtg falls taaaaaccca gacactgcat 405 Asn Lys Asp He Arg Lys Gly Lys Val His 90 95 aga 408 25 < 210 > 440 < 211 > 95 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 440 Met Leu Ser Glu Leu Phe Pro Leu Wing Met Arg Gly Phe Wing He Gly 1 5 10 15 He Ser Val Phe Phe Leu Trp He Wing Asn Wing Phe Leu Gly Leu Phe • 20 25 30 Phe Pro Thr He Met Glu Wing Val Gly Leu Thr Gly Thr Phe Phe Met 35 40 45 Phe Wing Gly He Gly Val Val Wing Leu He Phe He Tyr Thr Gln Val 50 55 60 Pro Glu Thr Arg Gly Arg Thr Leu Glu Glu He Asp Glu Asp Val Thr 65 70 75 80 Ser Gly Val He Phe Asn Lys Asp He Arg Lys Gly Lys Val His 85 90 95 < 210 > 441 10 < 211 > 789 < 212 > DNA < 213 > Corynebacterium glutamicum • < 220 > < 221 > CDS < 222 > (101) .. (766) < 223 > RXN00092 < 400 > 441 egaaaccaga aacacccagc ggctcctcgt egaaaagega atctttgaac tagaagccca 60 ggcacgttgg ctcgaccgaa ttgaagcatt ggagcagtaa atg aac aac acct ect 115 15 Met Thr Asn Thr Pro 1 5 ttc ccc ctt gaa ctt caa aac ate tcc tgc gcc ttc gga gaa ggc cca 163 Phe Pro Leu Glu Leu Gln Asn He Ser Cys Wing Phe Gly Glu Gly Pro 10 15 20 cgc falls gtc tcc gcg etc aac aac gtc tcg ctg gca gtc aat ccc ggc 211 Arg His Val Ser Ala Leu Asn Asn Val Ser Leu Ala Val Asn Pro Gly 25 30 35 gaa etc gtt gcc ate atg ggc ccg tcc ggc tea gga aaa tcc acc ttg 259 Glu Leu Val Wing He Met Gly Pro Ser Gly Ser Gly Lys Ser Thr Leu 40 45 50 etc aac gtc gcc gcg etc ctg cag cgc gca acc tet ggc cat gtg ctt 307 2 Leu Asn Val Wing Gly Leu Leu Gln Arg Wing Thr Ser Gly His Val Leu 55 60 65 ate gac ggt gcc age gcc tea gac etc aac gcc aaa cgc gca gct gaa 355 He Asp Gly Ala Be Ala Be Asp Leu Asn Ala Lys Arg Ala Ala Glu 70 75 80 85 acc agg cgt cgc falls ate gga gtt att ttc caac aac taac aac ctg gtc 403 Thr Arg Arg Arg His He Gly Val He Phe Gln Asn Tyr Asn Leu Val 90 95 100 ccc acc etc acc gtc gga gaa aac gtc ggt ctg ccc cta gaa etc gac 451 Pro Thr Leu Thr Val Gly Glu Asn Val Gly Le u Pro Leu Glu Leu Asp 105 110 115 ggc aaa acc gac cgc cag gca gta gca ate gca etc gcg gaa gtc ggc 499 25 Gly Lys Thr Asp Arg Gln Ala Val Ala Wing Ala Leu Wing Glu Val Gly ^ ±. i, & i to 120 125 130 etc gaa ggc ttc gac gac cgc ttc ccc gaa gag ate tcc ggc ggc caa 547 Leu Glu Gly Phe Asp Asp Arg Phe Pro Glu Glu He Ser Gly Gly Gln 135 140 145 gcc cag cgc gtc gcc gcg ate gcg aga gcc gcc aga cc cga cga aaa ate 595 Wing Gln Arg Wing Wing Wing Arg Ala Leu Wing Gly Pro Arg Lys He 150 155 160 165 ttg ctt gcc gac gac ccc acc ggc gcc etc gac acc tcc acc ggc gac 643 Leu Leu Wing Asp Glu Pro Thr Gly Wing Leu Asp Thr Ser Thr Gly Asp • 170 175 180 gca gtc etc cgc gtc etc cgc ca aga ate gat tcc ggt gcc gca ggc 691 Wing Val Leu Arg Val Leu Arg Gln Arg He Asp Ser Gly Ala Wing Gly 185 190 195 etc ctt gtc acc cae gaa ccc cgc tcc gcc gcg tgg gca gac cga here 739 Leu Leu Val Thr His Glu Pro Arg Phe Wing Wing Trp Wing Asp Arg Thr 200 205 210 tie atg ctt agg gat ggt gaa ate cag tgaccacact tetageagea 786 He Met Leu Arg Asp Gly Glu He Gln 215 220 acc 789 10 < 210 > 442 < 211 > 222 < 212 > PRT • < 213 > Corynebacterium glutamicum < 400 > 442 Met Thr Asn Thr Pro Phe Pro Leu Glu Leu Gln Asn He Ser Cys Wing 1 5 10 15 Phe Gly Glu Gly Pro Arg His Val Ser Wing Leu Asn Asn Val Ser Leu 20 25 30 Wing Val Asn Pro Gly Glu Leu Val Wing He Met Gly Pro Ser Gly Ser 35 40 45 15 Gly Lys Ser Thr Leu Leu Asn Val Wing Gly Leu Leu Gln Arg Wing Thr 50 55 60 Ser Gly His Val Leu He Asp Gly Wing Being Wing Being Asp Leu Asn Wing 65 70 75 80 Lys Arg Wing Wing Glu Thr Arg Arg Arg His He Gly Val He Phe Gln 85 90 95 Asn Tyr Asn Leu Val Pro Thr Leu Thr Val Gly Glu Asn Val Gly Leu 100 105 110 • Pro Leu Glu Leu Asp Gly Lys Thr Asp Arg Gln Wing Wing Wing 115 120 125 Leu Wing Glu Val Gly Leu Glu Gly Phe Asp Asp Arg Phe Pro Glu Glu 20 130 135 140 He Ser Gly Gly Gln Wing Gln Arg Val Wing He Wing Arg Ala Leu He 145 150 155 160 Gly Pro Arg Lys He Leu Leu Wing Asp Glu Pro Thr Gly Wing Leu Asp 165 170 175 Thr Ser Thr Gly Asp Wing Val Leu Arg Val Leu Arg Gln Arg He Asp 180 185 190 Ser Gly Wing Wing Gly Leu Leu Val Thr His Glu Pro Arg Phe Wing Wing 195 200 205 Trp Wing Asp Arg Thr He Met Leu Arg Asp Gly Glu He Gln 210 215 220 25 < 210 > 443 < 211 > 227 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (204) < 223 > FRXA00092 • < 400 > 443 ate gcg aga gcc etc ate ggc ccc cga aaa ate ttg ctt gcc gac gaa 48 I have Ala Arg Ala Leu I have Gly Pro Arg Lys He Leu Leu Ala Asp Glu 1 5 10 15 ccc acc ggc gcc etc gac acc tcc acc ggc gac gca gtc etc cgc gtc 96 Pro Thr Gly Ala Leu Asp Thr Ser Thr Gly Asp Ala Val Leu Arg Val 20 25 30 etc cgc ca aga ate gat tcc ggt gcc gca ggc etc ctt gtc acc falls 144 Leu Arg Gln Arg He Asp Ser Gly Ala Wing Gly Leu Leu Val Thr His 35 40 45 gaa ccc cgc tcg gcc gcg tgg gca gac cga here ate atg ctt agg gat 192 10 Glu Pro Arg Phe Wing Wing Trp Wing Asp Arg Thr He Met Leu Arg Asp 50 55 60 ggt gaa ate cag tgaccacact tetageagea acc 227 Gly Glu He Gln 65 < 210 > 444 < 211 > 68 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 444 15 He Ala Arg Ala Leu He Gly Pro Arg Lys He Leu Leu Wing Asp Glu 1 5 10 15 Pro Thr Gly Wing Leu Asp Thr Ser Thr Gly Asp Wing Val Leu Arg Val 20 25 30 Leu Arg Gln Arg He Asp Ser Gly Wing Wing Gly Leu Leu Val Thr His 35 40 45 Glu Pro Arg Phe Wing Wing Trp Wing Asp Arg Thr He Met Leu Arg Asp 50 55 60 Gly Glu He Gln • 65 < 210 > 445 20 < 211 > 975 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (952) < 223 > RXN03060 < 400 > 445 tatgtccttt ggctccggta ccctggcagg agtacctggg ctgtttttct aaaatggcct 60 gacgttttca agattgaatt taaggaaagc atcgtagttc atg agt aac ect gcc 115 25 Met Ser Asn Pro Wing 1 5 gcg age here ect gcc aac aat tcg gac gat gtt gcg aag gag aat tgg 163 Wing Being Thr Pro Wing Asn Asn Being Asp Asp Val Wing Lys Glu Asn Trp 10 15 20 gac tet tet ttt acg ccg aag act gac att gac tet tcc cag ect gtc 211 Asp Ser Ser Phe Thr Pro Lys Thr Asp He Asp Ser Ser Gln Pro Val 25 30 35 aat aac tcg act ggt gaa gcc gct gcg cgc gca gtg aac ctg tac aag 259 • Asn Asn Ser Thr Gly Glu Wing Wing Wing Arg Wing Val Asn Leu Tyr Lys 40 45 50 gcg tat ggc cag ggt gat acc act gtc acc gcg ttg gat fall gtc aac 307 Wing Tyr Gly Gln Gly Asp Thr Thr Val Thr Wing Leu Asp His Val Asn 55 60 65 gtg gag ttt gag aag aac aag tcc act gcc att ggt ect tet ggc 355 Val Glu Phe Glu Lys Asn Lys Phe Thr Ala He Met Gly Pro Ser Gly 70 75 80 85 tcg ggt aag tcc acg ttg atg drops tgc atg gct ggt ctg gat gct gcg 403 Ser Gly Lys Ser Thr Leu Met His Cys Met Wing Gly Leu Asp Wing Wing 90 95 100 act ggt ggt tcg gca ttc att ggt gat acg gat ctg tcg cgg ttg aag 451 10 Thr Gly Gly Be Wing Phe He Gly Asp Thr Asp Leu Ser Arg Leu Lys 105 110 115 gac aaa gag atg acc tet tgc cgt cgt gat cgt ttg gt ttc att ttc 499 Asp Lys Glu Met Thr Ser Leu Arg Arg Asp Arg Leu Gly Phe He Phe • 120 125 130 cag tcg ttc aac ttg gtt ect act ctg acg gcg tcg gag aac att acg 547 Gln Ser Phe Asn Leu Val Pro Thr Leu Thr Ala Ser Glu Asn He Thr 135 140 145 ctg ect acc gat ate gcg ggc cgc aag att gat cag tcg tgg ttc gat 595 Leu Pro Thr Asp He Wing Gly Arg Lys He Asp Gln Ser Trp Phe Asp 150 155 160 165 gag att acc tet cgt ctg ggt ctg act gag cgc ctt aag falls cgt ect 643 15 Glu He Thr Ser Arg Leu Gly Leu Thr Glu Arg Leu Lys His Arg Pro 170 175 180 gca gag etc tet ggt ggt cag cag cag cgt gtg gcg tgt gct cgt gcg 691 Wing Glu Leu Ser Gly Gly Gln Gln Gln Arg Val Wing Cys Wing Arg Wing 185 190 195 ttg gtg tet cgt ccg gag ate att ttc ggc gac gag cca acc ggt aac 739 Leu Val Ser Arg Pro Glu He He Phe Gly Asp Glu Pro Thr Gly Asn 200 205 210 ttg gat tcg aac tet tet agg gaa gtg ctg gat ate ctg cgc acc gca 787 Leu Asp Being Asn Ser Being Arg Glu Val Leu Asp He Leu Arg Thr Wing 215 220 225 gtt gat cag gat gat gtg gtt gtg ate gtt acc fall gat gcc aag 835 20 Val Asp Gln Asp Asp Gln Thr Val Val He Val Thr flis Asp Ala Lys 230 235 240 245 gcg gcg tcc tat gca gat cgt gtc att ttc ttg gcg gac ggt cgt ate 883 Wing Wing Tyr Wing Asp Arg Val He Phe Leu Wing Asp Gly Arg He 250 255 260 gtg aac cag ttg ttt gat ccc acc ate gag gaa ate ttg gcc acg atg 931 Val Asn Gln Leu Phe Asp Pro Thr He Glu Glu He Leu Ala Thr Met 265 270 275 aac gga att gag gat att gcc taatgaattc cggttccaca atg 975 Asn Gly He Glu Asp He Ala 280 25 < 210 > 446 < 211 > 284 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 446 Met Ser Asn Pro Wing Wing Ser Thr Pro Wing Asn Asn Ser Asp Asp Val 1 5 10 15 Wing Lys Glu Asn Trp Asp Being Ser Phe Thr Pro Lys Thr Asp He Asp 20 25 30 • Ser Ser Gln Pro Val Asn Asn Ser Thr Gly Glu Wing Wing Wing Arg Wing 35 40 45 Val Asn Leu Tyr Lys Wing Tyr Gly Gln Gly Asp Thr Thr Val Thr Wing 50 55 60 Leu Asp His Val Asn Val Glu Phe Glu Lys Asn Lys Phe Thr Wing He 65 70 75 80 Met Gly Pro Ser Gly Ser Gly Lys Be Thr Leu Met His Cys Met Wing 85 90 95 Gly Leu Asp Wing Wing Thr Gly Gly Ser Wing Phe He Gly Asp Thr Asp 100 105 110 Leu Ser Arg Leu Lys Asp Lys Glu Met Thr Ser Leu Arg Arg Asp Arg 115 120 125 10 Leu Gly Phe He Phe Gln Ser Phe Asn Leu Val Pro Thr Leu Thr Wing 130 135 140 Ser Glu Asn He Thr Leu Pro Thr Asp He Wing Gly Arg Lys He Asp • 145 150 155 160 Gln Ser Trp Phe Asp Glu He Thr Ser Arg Leu Gly Leu Thr Glu Arg 165 170 175 Leu Lys His Arg Pro Wing Glu Leu Ser Gly Gln Gln Gln Gln Arg Val 180 185 190 Ala Cys Ala Arg Ala Leu Val Ser Arg Pro Glu He He Phe Gly Asp 19 5 200 205 Glu Pro Thr Gly Asn Leu Asp Ser Asn Ser Ser Arg Glu Val Leu Asp 15 210 215 220 He Leu Arg Thr Ala Val Asp Gln Asp Asp Gln Thr Val Val He Val 225 230 235 240 Thr His Asp Ala Lys Ala Ala Be Tyr Wing Asp Arg Val He Phe Leu 245 250 255 Wing Asp Gly Arg He Val Asn Gln Leu Phe Asp Pro Thr He Glu Glu 260 265 270 He Leu Wing Thr Met Asn Gly He Glu Asp He Wing 275 280 < 210 > 447 < 211 > 538 20 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (538) < 223 > FRXA02618 < 400 > 447 egaaaccaga aacacccagc ggctcctcgt egaaaagega atetttgaac tagaagccca 60 ggcacgttgg ctcgaccgaa ttgaagcatt ggagcagtaa atg aac aac acct ect 115 Met Thr Asn Thr Pro 25 1 5 ttc ccc ctt gaa ctt caa aac ate tcc tgc gcc ttc gga gaa ggc cca 163 Phe Pro Leu Glu Leu Gln Asn He Ser Cys Wing Phe Gly Glu Gly Pro 10 15 20 cgc falls gtc tcc gcg etc aac aac gtc tcg ctg gca gtc aat ccc ggc 211 Arg His Val Ser Ala Leu Asn Asn Val Ser Leu Ala Val Asn Pro Gly 25 30 35 gaa etc gtt gcc ate atg ggc ccg tcc ggc tea gga aaa tcc acc ttg 259 Glu Leu Val Wing He Met Gly Pro Ser Gly Ser Gly Lys Ser Thr Leu 40 45 50 etc aac gtc gcc ggc etc ctg cag cgc gca acc tet ggc cat gtg ctt 307 Leu Asn Val Wing Gly Leu Leu Gln Arg Wing Thr Ser Gly His Val Leu 55 60 65 ate gac ggt gcc age gcc tea gac etc aac gcc aaa cgc gca gct gaa 355 He Asp Gly Ala Be Ala Be Asp Leu Asn Ala Lys Arg Ala Ala Glu 70 75 80 85 acc agg cgt cgc cae ate gga gtt att ttc ca aac tac aac ctg gtc 403 Thr Arg Arg Arg His He Gly Val He Phe Gln Asn Tyr Asn Leu Val 90 95 100 ccc acc etc acc gtc gga gaa aac ate ggt ctg ccc cta gaa etc gac 451 Pro Thr Leu Thr Val Gly Glu Asn He Gly Leu Pro Leu Glu Leu Asp 105 110 115 ggc aaa acc gac cgc cag gca gta gca gca ate gca etc gcg gaa gtc ggc 499 Gly Lys Thr Asp Arg Gln Wing Val Wing He Wing Leu Wing Glu Val Gly 120 125 130 etc aag ggc tet acg acc gct ttt ccc gag aga tet ctg 538 Leu Lys Gly Ser Thr Thr Wing Phe Pro Glu Arg Ser Leu 135 140 145 < 210 > 448 < 211 > 146 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 448 Met Thr Asn Thr Pro Phe Pro Leu Glu Leu Gln Asn He Ser Cys Ala 1 5 10 15 Phe Gly Glu Gly Pro Arg His Val Ser Wing Leu Asn Asn Val Ser Leu 20 25 30 Wing Val Asn Pro Gly Glu Leu Val Wing He Met Gly Pro Ser Gly Ser 35 40 45 Gly Lys Ser Thr Leu Leu Asn Val Ala Gly Leu Leu Gln Arg Ala Thr 50 55 60 Ser Gly His Val Leu He Asp Gly Ala Ser Ala Be Asp Leu Asn Ala 65 70 75 80 Lys Arg Wing Wing Glu Thr Arg Arg Arg His He Gly Val He Phe Gln 85 90 95 Asn Tyr Asn Leu Val Pro Thr Leu Thr Val Gly Glu Asn He Gly Leu 100 105 110 Pro Leu Glu Leu Asp Gly Lys Thr Asp Arg Gln Ala Wing Ala Wing 115 120 125 Leu Wing Glu Val Gly Leu Lys Gly Ser Thr Thr Wing Phe Pro Glu Arg 130 135 140 Ser Leu 145 < 210 > 449 < 211 > 975 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (952) < 223 > FRXA02900 < 400 > 449 • tatgtcc'ttt lggcticcggta ccctggcagg agtacctggg ctgtttttct, yyyy-tggcct 60 gacgttttca, agattgaatt taggaaggc atcgtagttc atg agt aac ect gcc 115 Met Ser Asn Pro Wing 1 5 gcg age here ect gcc aac aat tcg gac gat gtt gcg aag gag aat tgg 163 Wing Being Thr Pro Wing Asn Asn Being Asp Asp Val Wing Lys Glu Asn Trp 10 15 20 gac tet tet ttt acg ccg aag act gac att gac tet tcc cag ect gtc 211 Asp Being Being Phe Thr Pro Lys Thr Asp Asp Being Ser Gln Pro Val 25 30 35 aat aac tcg act ggt gaa gcc gct gcg cgc gca gtg aac ctg tac aag 259 10 Asn Asn Be Thr Gly Glu Wing Wing Wing Arg Wing Val Asn Leu Tyr Lys 40 45 50 gcg tat ggc cag ggt gat acc act gtc acc gcg ttg gat fall gtc aac 307 Wing Tyr Gly Gln Gly Asp Thr Thr Val Thr Wing Leu Asp His Val Asn 55 60 65 gtg gag ttt gag aag aac aag ttc act gcc ate atg ggt ect tet ggc 355 Val Glu Phe Glu Lys Asn Lys Phe Thr Wing He Met Gly Pro Ser Gly 70 75 80 85 tcg ggt aag tcc acg ttg atg drops tgc atg gct ggt ctg gat gct gcg 403 Be Gly Lys Be Thr Leu Met His Cys Met Wing Gly Leu Asp Wing Wing 90 95 100 act ggt ggt tcg gca ttc att ggt gat acg gat ctg tcg cgg ttg aag 451 15 Thr Gly Gly Be Wing Phe He Gly Asp Thr Asp Leu Ser Arg Leu Lys 105 110 115 gac aaa gag atg acc tet ttg cgt cgt gat cgt ttg gga ttc att ttc 499 Asp Lys Glu Met Thr Ser Leu Arg Arg Asp Arg Leu Gly Phe He Phe 120 125 130 cag tcg ttc aac ttg gtt ect act ctg acg gcg tcg gag aac att acg 547 Gln Ser Phe Asn Leu Val Pro Thr Leu Thr Wing Ser Glu Asn He Thr 135 140 145 ctg ect acc gat ate gcg ggc cgc aag att gat cag tcg tgg ttc gat 595 • Leu Pro Thr Asp He Wing Gly Arg Lys He Asp Gln Ser Trp Phe Asp 150 155 160 165 gag att acc tet cgt ctg ggt ctg act gag cgc ctt aag cae cgt ect 643 20 Glu He Thr Ser Arg Leu Gly Leu Thr Glu Arg Leu Lys His Arg Pro 170 175 180 gca gag etc tet ggt ggt cag cag cag cgt gtg gcg tgt gct cgt gcg 691 Wing Glu Leu Ser Gly Gly Gln Gln Gln Arg Val Wing Cys Wing Arg Wing 185 190 195 ttg gtg tet cgt ccg gag ate att ttc ggc gac gag cca acc ggt aac 739 Leu Val Ser Arg Pro Glu He He Phe Gly Asp Glu Pro Thr Gly Asn 200 205 210 ttg gat tcg aac tet tet agg gaa gtg ctg gat ate ctg cgc acc 787 Leu Asp Ser Asn Be Ser Arg Glu Val Leu Asp He Leu Arg Thr Wing 215 220 225 gtt gat cag gat gat gtg gtt gtg ate gtt acc fall gat gcc aag 835 25 Val Asp Gln Asp Asp Gln Thr Val Val He Val Thr His Asp Ala Lys 230 235 240 245 gcg gcg tcc tat gca gat cgt gtc att ttc ttg gcg gac ggt cgt ate 883 Wing Wing Tyr Wing Asp Arg Val He Phe Leu Wing Asp Gly Arg He 250 255 260 gtg aac cag ttg ttt gat ccc acc ate gag gaa ate ttg gcc acg atg 931 Val Asn Gln Leu Phe Asp Pro Thr He Glu Glu He Leu Ala Thr Met 265 270 275 aac gga att gag gat att gcc taatgaattc cggttccaca atg 975 Asn Gly He Glu Asp He Wing • 280 < 210 > 450 < 211 > 284 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 450 Met Ser Asn Pro Wing Wing Ser Thr Pro Wing Asn Asn As Asp Asp Val 1 5 10 15 Wing Lys Glu Asn Trp Asp Being Ser Phe Thr Pro Lys Thr Asp He Asp 20 25 30 10 Being Ser Gln Pro Val Asn Asn Being Thr Gly Glu Ala Ala Ala Ala 35 40 45 Val Asn Leu Tyr Lys Ala Tyr Gly Gln Gly Asp Thr Thr Val Thr Ala • 50 55 60 Leu Asp His Val Asn Val Glu Phe Glu Lys Asn Lys Phe Thr Ala He 65 70 75 80 Met Gly Pro Ser Gly Be Gly Lys Ser Thr Leu Met His Cys Met Wing 85 90 95 Gly Leu Asp Wing Wing Thr Gly Gly Ser Wing Phe He Gly Asp Thr Asp 100 105 110 Leu Ser Arg Leu Lys Asp Lys Glu Met Thr Ser Leu Arg Arg Asp Arg 115 120 125 15 Leu Gly Phe He Phe Gln Ser Phe Asn Leu Val Pro Thr Leu Thr Wing 130 135 140 Ser Glu Asn He Thr Leu Pro Thr Asp He Wing Gly Arg Lys He Asp 145 150 155 160 Gln Ser Trp Phe Asp Glu He Thr Ser Arg Leu Gly Leu Thr Glu Arg 165 170 175 Leu Lys His Arg Pro Wing Glu Leu Ser Gly Gln Gln Gln Gln Arg Val 180 185 190 • Ala Cys Ala Arg Ala Leu Val Ser Arg Pro Glu He He Phe Gly Asp 195 200 205 Glu Pro Thr Gly Asn Leu Asp Ser Asn Ser Ser Arg Glu Val Leu Asp 20 210 215 220 He Leu Arg Thr Wing Val Asp Gln Asp Asp Gln Thr Val Val He Val 225 230 235 240 Thr His Asp Ala Lys Ala Wing Be Tyr Wing Asp Arg Val He Phe Leu 245 250 255 Wing Asp Gly Arg He Val Asn Gln Leu Phe Asp Pro Thr He Glu Glu 260 265 270 He Leu Wing Thr Met Asn Gly He Glu Asp He Wing 275 280 <; 210 > 451 < 211 > 1452 25 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (1452) < 223 > RXS03212 < 400 > 451 gcc tea ctt aac tgg tea gtc ate gtt cca gcc cta gtc att gtc cta 48 Wing Ser Leu Asn Trp Ser Val He Val Pro Ala Leu Val He Val Leu 1 5 10 15 gcg here gtg gtg tgg ggt ate gga ttc aaa gat age ttt acc aac ttt 96 Wing Thr Val Val Trp Gly He Gly Phe Lys Asp Ser Phe Thr Asn Phe 20 25 30 gct agt tet gcg ttg tea gca gta gtt gac aat etc ggc tgg gcc ttc 144 Wing Being Ser Wing Leu Ser Wing Val Val Asp Asn Leu Gly Trp Wing Phe 35 40 45 att ttg ttt ggc here gtc ttt gta ttt ttt ate gtt gtt ate gcc gct 192 He Leu Phe Gly Thr Val Phe Val Phe Phe He Val Val He Ala Wing 50 55 60 10 agt aaa ttc ggc acg att cgc tta ggc cgc att gat gaa gca cca gag 240 Ser Lys Phe Gly Thr He Arg Leu Gly Arg He Asp Glu Wing Pro Glu 65 70 75 80 ttt cgc acg gtg tea tgg att tcc atg atg ttt gct gca ggt atg ggt 288 Phe Arg Thr Val Ser Trp He Ser Met Met Phe Wing Wing Gly Met Gly 85 90 95 att ggt ttg atg ttc tac gga acc ac gaa ect tta acc ttc tac cgc 336 He Gly Leu Met Phe Tyr Gly Thr Thr Glu Pro Leu Thr Phe Tyr Arg 100 105 110 aat ggt gta ect gga cat gat gaa falls aat gtt ggc gtt gct atg tcc 384 asn gly val pro gly his asp glu his asn val gly val ala met be 115 120 125 15 acg here atg ttc falls tgg acc ttg cat cca tgg gct ate tac gca att 432 Thr Thr Met Phe His Trp Thr Leu His Pro Trp Wing He Tyr Wing He 130 135 140 gtg ggc cta gcc att gcc tat tcg acc ttc cga gtg ggc cgt aaa cag 480 Val Gly Leu Ala He Ala Tyr Be Thr Phe Arg Val Gly Arg Lys Gln 145 150 155 160 ctt cta age tet gca ttc gtg cca etc att ggt gaa aaa ggt gca gaa 528 Leu Leu Ser Be Ala Phe Val Pro Leu He Gly Glu Lys Gly Ala Glu 165 170 175 • gga tgg ttg ggc aag etc. ate gac ate ctg gcg att ate gcc acc gta 576 Gly Trp Leu Gly Lys Leu He Asp He Leu Wing He He Wing Thr Val 180 185 190 20 ttc ggc acg gca tgt tcc ctt ggc ctt ggt gcc ctg cag att ggt gca 624 Phe Gly Thr Wing Cys Ser Leu Gly Leu Gly Wing Leu Gln He Gly Wing 195 200 205 ggc ctg tcc gca gca aac ate att gaa gat cca age gat tgg acc ate 672 Gly Leu Ser Ala Ala Asn He He Glu Asp Pro As Asp Trp Thr He 210 215 220 gtt ggc att gtt tet gtt ttg acc ctg gca ttt ate tc tcc gct att 720 Val Gly He Val Ser Val Leu Thr Leu Wing Phe He Phe Ser Wing He 225 230 235 240 tet ggt gtg ggc aag gga ate cag tac etc tcc aac gcc aac gtt 768 Ser Gly Val Gly Lys Gly He Gln Tyr Leu Ser Asn Ala Asn Met Val 245 250 255 25 ctg gca gct ctg etc gcg att ttc gtg gtg ttc gtc gga cca acc gtg 816 - - * * & & & - ^ a ^ ^? , tt * • *. », - ^ -, I lt t, Hl Leu Wing Wing Leu Leu Wing He Phe Val Phe Val Val Gly Pro Thr Val 260 265 270 tcg att ttg aac ctg ctg ct gc t tet att ggc aac tac ctg tcc aac 864 Be He Leu Asn Leu Leu Pro Gly Be He Gly Asn Tyr Leu Be Asn 275 280 285 ttc ttt ca ggc ggc gc gcc gc gc gc gc gcc Phe Phe Gln Met Wing Gly Arg Thr Ala Met Ser Wing Asp Gly Thr Wing 290 295 300 ggt gag tgg cta ggt age tgg acc ate ttc tac tgg gca tgg tgg ate 960 Gly Glu Trp Leu Gly Ser Trp Thr He Phe Tyr Trp Wing Trp Trp He 305 310 315 320 tet tgg tea cca ttc gta gga atg ttc ttg gca cgt att tcc cgt ggc 1008 Ser Trp Ser Pro Phe Val GíbMet Phe Leu Wing Arg He Ser Arg Gly 325 330 335 cgc tcc ate cgt gag ttc ate ctg ggc gtg ttg etc gtc cca gca ggt 1056 Arg Ser He Arg Glu Phe He Leu Gly Val Leu Leu Val Pro Wing Gly 340 345 350 gtg tcc acc gta tgg ttc tcc att ttt ggt ggc act gcg att gtc ttc 1104 Val Ser Thr Val Trp Phe Ser He Phe Gly Gly Thr Wing He Val Phe 355 360 365 10 gaa caa aat ggg gaa tcc att tgg ggt gat ggt gca gca gaa gag cag 1152 Glu Gln Asn Gly Glu Be He Trp Gly Asp Gly Wing Wing Glu Glu Gln 370 375 380 ctt ttt gga ttg ctt cat gca ctt cca ggt ggg ca ate ate ggc ate 1200 • Leu Phe Gly Leu Leu His Wing Leu Pro Gly Gly Gln He Met Gly He 385 390 395 400 ate gcc atg att ttg ctg ggt act ttc ttc att acc tet gct gac tet 1248 He Wing Met He Leu Leu Gly Thr Phe Phe He Thr Ser Wing Asp Ser 405 410 415 gct tcc acc gtc atg ggc acc atg agt cag falls ggc cag ctg gaa gcc 1296 Wing Being Thr Val Met Gly Thr Met Being Gln His Gly Gln Leu Glu Wing 420 425 430 15 aac aag tgg gtg here gct gcc tgg ggt gtt gct acc gca gct att gga 1344 Asn Lys Trp Val Thr Wing Wing Trp Gly Val Wing Thr Wing Wing He Gly 435 440 445 cta acg cta ttg ctt tet ggt ggt gac aat gcc ttg age aac ttg caa 1392 Leu Thr Leu Leu Leu Ser Gly Gly Asp Asn Ala Leu Ser Asn Leu Gln 450 455 460 aac gtc acc ate gtg gct gca here cca ttc ttg ttt gtg gtt att gga 1440 Asn Val Thr He Val Wing Wing Thr Pro Phe Leu Phe Val Val He Gly 465 470, 475 480 • ttg atg ttt gcg 1452 Leu Met Phe Ala 20 < 210 > 452 < 211 > 484 < 212 > PRT < 213 > Crycynebacterium glutamicurri < 400 > 452 Wing Ser Leu Asn Trp Ser Val He Val Pro Wing Leu Val He Val Leu 1 5 10 15 Wing Thr Val Val Trp Gly He Gly Phe Lys Asp Ser Phe Thr Asn Phe 20 25 30 Wing Being Ser Wing Leu Ser Wing Val Val Asp Asn Leu Gly Trp Wing Phe 25 35 40 45 He Leu Phe Gly Thr Val Phe Val Phe Phe He Val Val He Ala Wing 50 55 60 Ser Lys Phe Gly Thr He Arg Leu Gly Arg He Asp Glu Wing Pro Glu 65 70 75 80 Phe Arg Thr Val Ser Trp He Ser Met Met Phe Wing Wing Gly Met Gly 85 90 95 He Gly Leu Met Phe Tyr Gly Thr Thr Glu Pro Leu Thr Phe Tyr Arg 100 105 110 Asn Gly Val Pro Gly His Asp Glu His Asn Val Gly Val Ala Met Ser 115 120 125 Thr Thr Met Phe His Trp Thr Leu His Pro Trp Ala He Tyr Wing He 130 135 140 Val Gly Leu Wing He Wing Tyr Ser Thr Phe Arg Val Gly Arg Lys Gln 145 150 155 160 Leu Leu Ser Be Wing Phe Val Pro Leu He Gly Glu Lys Gly Wing Glu 165 170 175 Gly Trp Leu Gly Lys Leu He Asp He Leu Wing He He Wing Thr Val 180 185 190 Phe Gly Thr Ala Cys Ser Leu Gly Leu Gly Ala Leu Gln He Gly Wing 195 200 205 Gly Leu Ser Ala Ala Asn He He Glu Asp Pro Ser Asp Trp Thr He 210 215 220 Val Gly He Val Ser Val Leu Thr Leu Ala Phe He Phe Ser Ala He 225 230 235 240 Ser Gly Val Gly Lys Gly He Gln Tyr Leu Ser Asn Ala Asn Met Val 245 250 255 Leu Ala Ala Leu Leu Ala He Phe Val Phe Val Val Gly Pro Thr Val 260 265 270 Ser He Leu Asn Leu Pro Gly Ser He Gly Asn Tyr Leu Ser Asn 275 280 285 Phe Phe Gln Met Wing Gly Arg Thr Ala Met Ser Wing Asp Gly Thr Wing 290 295 300 Gly Glu Trp Leu Gly Ser Trp Thr He Phe Tyr Trp Wing Trp Trp He 305 310 315 320 Ser Trp Ser Pro Phe Val Gly Met Phe Leu Wing Arg He Ser Arg Gly 325 330 335 Arg Ser He Arg Glu Phe He Leu Gly Val Leu Leu Val Pro Wing Gly 340 345 350 Val Ser Thr Val Trp Phe Ser He Phe Gly Gly Thr Wing He Val Phe 355 360 365 Glu Gln Asn Gly Glu Ser He Trp Gly Asp Gly Ala Glu Glu Gln Wing 370 375 380 Leu Phe Gly Leu Leu His Wing Leu Pro Gly Gly Gln He Met Gly He 385 390 395 400 He Wing Met He Leu Leu Gly Thr Phe Phe He Thr Ser Wing Asp Ser 405 410 415 Wing Being Thr Val Met Gly Thr Met Being Gln His Gly Gln Leu Glu Wing 420 425 430 Asn Lys Trp Val Thr Wing Wing Trp Gly Val Wing Thr Wing Wing He Gly 435 440 445 Leu Thr Leu Leu Leu Ser Gly Gly Asp Asn Ala Leu Ser Asn Leu Gln 450 455 460 Asn Val Thr He Val Wing Wing Thr Pro Phe Leu Phe Val Val He Gly 465 470 475 480 Leu Met Phe Ala < 210 > 453 .i l .¿ »J. _, < 211 > 945 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) •• (945) < 223 > FRXA01591 • < 400 > 453 ggcccc tteeaa cctttt aaaacc ttgggg tteeaa ggttcc aattee ggtttt cca gcc cta gtc att gtc cta 48 A Allaa S Seerr L Leeuu A Assnn T Trrpp S Seerr V Vaall H Hee V Vaall Pro Wing Leu Val He Val Leu 1 5 10 15 gcg here gtg gtg tgg ggt ate gga ttc aaa gat age ttt action acc ttt 96 Wing Thr Val Val Trp Gly He Gly Phe Lys Asp Ser Phe Thr Thr Phe 20 25 30 gct agt tet gcg ttg tea gca gta gtt gac aat etc ggc tgg gcc ttc 144 Wing Being Being Wing Leu Being Wing Val Val Asp Asn Leu Gly Trp Wing Phe 35 40 45 att ttg ttt ggc here gtc ttt gta ttt ttt ate gtt gtt ate gcc gct 192 He Leu Phe Gly Thr Val Phe Val Phe Phe He Val Val He Ala Wing 10 50 55 60 agt aaa ttc ggc acg att cgc tta ggc cgc att gat gaa gca cca gag 240 Be Lys Phe Gly Thr He Arg Leu Gly Arg He Asp Glu Wing Pro Glu 65 70 75 80 ttt cgc acg gtg tea tgg att tcc atg tg ttt gct gca ggt atg ggt 288 Phe Arg Thr Val Ser Trp He Met Met Met Phe Ala Ala Gly Met Gly 85 90 95 att ggt ttg atg ttc tac gga acc ac gaa ect tta acc ttc tac cgc 336 He Gly Leu Met Phe Tyr Gly Thr Thr Glu Pro Leu Thr Phe Tyr Arg 100 105 110 aat ggt gta ect gga cat gat gaa falls aat gtt ggc gtt gct atg tcc 384 15 Asn Gly Val Pro Gly His Asp Glu His Asn Val Gly Val Ala Met Ser 115 120 125 acg here at ttc falls tgg acc ttg cat cca tgg gct ate tac gca att 432 Thr Thr Met Phe His Trp Thr Leu His Pro Trp Wing He Tyr Wing He 130 135 140 gtg ggc cta gcc att gcc tat tcg acc ttc cga gtg ggc cgt aaa cag 480 Val Gly Leu Ala He Ala Tyr Ser Thr Phe Arg Val Gly Arg Lys Gln 145 150 155 160 ctt cta age tet gca ttc gtg cca etc att ggt gaa aaa ggt gca gaa 528 • Leu Leu Ser Be Wing Phe Val Pro Leu He Gly Glu Lys Gly Wing Glu 165 170 175 gga tgg tg ggc aag etc ate gac ate ctg gcg att ate gcc acc gta 576 20 Gly Trp Leu Gly Lys Leu He Asp He Leu Wing He He Wing Thr Val 180 185 190 ttc ggc acg gca tgt tcc ctt ggc ctt ggt gcc ctg cag att ggt gca 624 Phe Gly Thr Ala Cys Ser Leu Gly Leu Gly Ala Leu Gln He Gly Wing 195 200 205 ggc ctg tcc gca gca aac ate att gaa gat cca age gat tgg acc ate 672 Gly Leu Ser Wing Wing Asn He He Glu Asp Pro Being Asp Trp Thr He 210 215 220 gtt ggc att gtt tet gtt ttg acc ctg gca ttt ate ttc tcc gct att 720 Val Gly He Val Val Leu Thr Leu Ala Phe He Phe Ser Ala He 225 230 235 240 tet ggt gg gg ggc aag gga ate cag tac etc tcc aac gcc aac atg gtt 768 25 Ser Gly Val Gly Lys Gly He Gln Tyr Leu Ser Asn Ala Asn Met Val 245 250 255 ctg gca gct ctg etc gcg att ttc gtg ttc gtt gtc gga cca acc gtg 816 Leu Ala Ala Leu Leu Ala He Phe Val Phe Val Val Gly Pro Thr Val 260 265 270 tcg att ttg aac ctg ctg ct ggt tet att gtg aac tac ctg tcc aac 864 Ser He Leu Asn Leu Leu Pro Gly Ser He Val Asn Tyr Leu Ser Asn 275 280 285 ttc ttt catt atg gta ggc cgc act gcc atg agt gcc gac ggc here cca 912 • Phe Phe Gln Met Val Gly Arg Thr Ala Met Ser Wing Asp Gly Thr Pro 290 295 300 ggt gag tgg ctt ggt ggc tgc acc ate ttc tac 945 Gly Glu Trp Leu Gly Gly Cys Thr He Phe Tyr 305 310 315 < 210 > 454 < 211 > 315 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 454 Wing Being Leu Asn Trp Being Val He Val Pro Wing Leu Val He Val Leu 10 1 5 10 15 Wing Thr Val Val Trp Gly He Gly Phe Lys Asp Ser Phe Thr Thr Phe • 20 25 30 Wing Being Ser Wing Leu Ser Wing Val Val Asp Asn Leu Gly Trp Wing Phe 35 40 45 He Leu Phe Gly Thr Val Phe Val Phe Val Val He Wing Wing 50 55 60 Ser Lys Phe Gly Thr He Arg Leu Gly Arg He Asp Glu Wing Pro Glu 65 70 75 80 Phe Arg Thr Val Ser Trp He Ser Met Met Met Phe Ala Ala Gly Met Gly 85 90 95 He Gly Leu Met Phe Tyr Gly Thr Thr Glu Pro Leu Thr Phe Tyr Arg 15 100 105 110 Asn Gly Val Pro Gly His Asp Glu His Asn Val Gly Val Ala Met Ser 115 120 125 Thr Thr Met Phe His Trp Thr Leu His Pro Trp Wing He Tyr Wing He 130 135 140 Val Gly Leu Wing He Wing Tyr Ser Thr Phe Arg Val Gly Arg Lys Gln 145 150 155 160 • Leu Leu Ser Be Ala Phe Val Pro Leu He Gly Glu Lys Gly Wing Glu 165 170 175 Gly Trp Leu Gly Lys Leu He Asp He Leu Wing He He Wing Thr Val 180 185 190 20 Phe Gly Thr Wing Cys Ser Leu Gly Leu Gly Wing Leu Gln He Gly Wing 195 200 205 Gly Leu Ser Wing Wing Asn He He Glu Asp Pro Be Asp Trp Thr He 210 215 220 Val Gly He Val Val Leu Thr Leu Ala Phe He Phe Ser Ala He 225 230 235 240 Ser Gly Val Gly Lys Gly He Gln Tyr Leu Ser Asn Ala Asn Met Val 245 250 2 55 Leu Ala Ala Leu Leu Ala He Phe Val Phe Val Val Gly Pro Thr Val 260 265 270 Ser He Leu Asn Leu Leu Pro Gly Ser He Val Asn Tyr Leu Ser Asn 275 280 285 25 Phe Phe Gln Met Val Gly Arg Thr Ala Met Be Wing Asp Gly Thr Pro 290 295 300 Gly Glu Trp Leu Gly Gly Cys Thr He Phe Tyr 305 310 315 <; 210 > 455 < 211 > 292 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (292) < 223 > RXN00201 < 400 > 455 aegtegegga cttcaagtag tcggcgatga aaaagtccgt ttactaaacc ccgatctgtg 60 ttacgccatc gcgcggctcg ggcacaccga tacctgggca gtg gca gat tgc gga 115 Val Wing Asp Cys Gly 1 5 tta ccc ate cca gaa falls gta gag ate ate gat ttg gca etc gtg ttt 163 Leu Pro He Pro Glu His Val Glu He He Asp Leu Ala Leu Val Phe 10 15 20 ggg ate ccc acc ttt gaa cata gta ctg aat gct etc aag ccg gaa gta 211 Gly He Pro Thr Phe Glu Gln Val Leu Asn Ala Leu Lys Pro Glu Val 25 30 35 gtt gtg gaa ggc gcg gtg att gcc gaa ggg gca ccc ca cgt ate cgc 259 Val Val Glu Gly Ala Val He Ala Glu Gly Ala Pro Gln Arg He Arg 40 45 50 gaa atg gtg gat acg gat gtg gaa gta tgt gcg 292 Glu Met Val Asp Thr Asp Val Glu Val Cys Wing 55 60 < 210 > 456 < 211 > 64 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 456 Val Wing Asp Cys Gly Leu Pro He Pro Glu His Val Glu He He Asp 1 5 10 15 Leu Ala Leu Val Phe Gly He Pro Thr Phe Glu Gln Val Leu Asn Wing 20 25 30 Leu Lys Pro Glu Val Val Val Glu Gly Ala Val He Wing Glu Gly Wing 35 40 45 Pro Gln Arg He Arg Glu Met Val Asp Thr Asp Val Glu Val Cys Wing 50 55 60 < 210 > 457 < 211 > 286 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (286) < 223 > FRXA00201 -A *, t J ^ < 400 > 457 aegtegegga cttcaagtag tcggcgatga aaaagtccgt ttactaaacc ccgatctgtg 60 ttacgccatc gcgcggctcg ggcacaccga tacctgggca gtg gca gat tgc gga 115 Val Wing Asp Cys Gly 1 5 tta ccc ate cca gaa falls gta gag ate ate gat ttg gca etc gtg ttt 163 Leu Pro He Pro Glu His Val Glu He He Asp Leu Ala Leu Val Phe 10 15 20 • ggg ate ccc acc ttt gaa cata gta ctg aat gct etc aag ccg gaa gta 211 Gly He Pro Thr Phe Glu Gln Val Leu Asn Ala Leu Lys Pro Glu Val 25 30 35 gtt gtg gaa ggc gcg gtg att gcc gaa ggg gca ccc ca cgt ate cgc 259 Val Val Glu Gly Ala Val He Ala Glu Gly Ala Pro Gln Arg He Arg 40 45 50 gaa atg gtg gat acg gat gtg gaa gtt 286 Glu Met Val Asp Thr Asp Val Glu Val 55 60 < 210 > 458 < 211 > 62 < 212 > PRT 10 < 213 > Corynebacterium glutamicum # < 400 > 458 Val Wing Asp Cys Gly Leu Pro He Pro Glu His Val Glu He He Asp 1 5 10 15 Leu Ala Leu Val Phe Gly He Pro Thr Phe Glu Gln Val Leu Asn Wing 20 25 30 Leu Lys Pro Glu Val Val Val Glu Gly Ala Val He Wing Glu Gly Wing 35 40 45 Pro Gln Arg He Arg Glu Met Val Asp Thr Asp Val Glu Val 50 55 60 15 < 210 > 459 < 211 > 849 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (826) < 223 > RXA01221 < 400 > 459 20 tccagggtgc gatcctggtt ctcgtgatcg tgttgctgcc gggcggaatt gcttcaatta 60 aactttccgc gctcaaaaat aaggccagga aggccacctc atg age ctt aaa ate 115 Met Ser Leu Lys He 1 5 acc aac etc aaa gtc gct ttc ggg tcg tcc ate gcc gtg aat gag att 163 Thr Asn Leu Lys Val Wing Phe Gly Ser Phe He Wing Val Asn Glu He 10 15 20 agt ttt cag gtg ctg ccc ggt falls gtc falls ttc etc ate ggt gcc aac 211 Ser Phe Gln Val Leu Pro Gly His Val His Phe Leu He Gly Ala Asn 25 30 35 ggt gca ggt aaa acc acc tgc att gac gcg ate age gga ttg gcg ccg 259 Gly Wing Gly Lys Thr Thr Cys He Asp Wing He Ser Gly Leu Wing Pro 25 40 45 50 ggg cag gga tea gtg cag ttg gat ggc act gag att ctg gga acc ect 307 Gly Gln Gly Ser Val Gln Leu Asp Gly Thr Glu He Leu Gly Thr Pro 55 60 65 gtg falls cgc att gct cgg atg ggt gtg ggg cga acg ttt cag acc gcc 355 Val His Arg He Wing Arg Met Gly Val Gly Arg Thr Phe Gln Thr Wing 70 75 80 85 age gtg ttt gaa gaa ttg tet gtg ttg cag aat ctg gat att gcg tgc 403 Ser Val Phe Glu Glu Leu Ser Val Leu Gln Asn Leu Asp He Wing Cys 90 95 * 100 • ggg att cat cgt ccg ttg cgg gcg ctt etc ggg gtg cgt cat cgg att 451 Gly He His Arg Pro Leu Arg Wing Leu Leu Gly Val Arg His Arg He 105 110 115 gat ccc cga att gaa falls gcc ctg gag gtc acg ggt ctt gct gat ctg 499 Asp Pro Arg He Glu His Wing Leu Glu Val Thr Gly Leu Wing Asp Leu 120 125 130 gtg aat gct cag gcg gga acc ttg tcg cat ggg cag aaa cag tgg ctg 547 Val Asn Ala Gln Ala Gly Thr Leu Ser His Gly Gln Lys Gln Trp Leu 135 140 145 gaa att gca atg ttg ctg gtg cag gat gcg cag gtg etc atg ctg gat 595 Glu He Ala Met Leu Leu Val Gln Asp Ala Gln Val Leu Met Leu Asp 10 150 155 160 165 gag ccg gtg gcg ggc atg agt gag gag gag cgt gtc gca acg ggt gag 643 Glu Pro Val Wing Gly Met Ser Glu Glu Glu Arg Val Wing Thr Gly Glu 170 175 180 ctt ttg cag agg gtt gcg cgg gga cgg gtg gtg ttg gtg gtg gag drops 691 Leu Leu Gln Arg Val Wing Arg Gly Arg Val Val Leu Val Val Glu His 185 190 195 gat atg gag ttc atg cgt cgt ttt gcc act cgc gtc act gtg atg aat 739 Asp Met Glu Phe Met Arg Arg Phe Wing Thr Arg Val Thr Val Met Asn 200 205 210 cgc ggc acg ate ttg tgt gag ggg tcg gtc gat gag att cag gcg aat 787 Arg Gly Thr He Leu Cys Glu Gly Ser Val Asp Glu He Gln Ala Asn 15 215 220 225 ccg gat gtg cag tcc att tat tta ggt acg gca ggg aag tgagttagtc 836 Pro Asp Val Gln Ser He Tyr Leu Gly Thr Wing Gly Lys 230 235 240 atgttggalaa tea 849 <; 210 > 460 < 211 > 242 < 212 > PRT • < 213 > Corynebacterium glutamicum < 400 > 460 20 Met Ser Leu Lys He Thr Asn Leu Lys Val Wing Phe Gly Ser Phe He 1 5 10 15 Wing Val Asn Glu He Ser Phe Gln Val Leu Pro Gly His Val His Phe 20 25 30 Leu He Gly Wing Asn Gly Wing Gly Lys Thr Thr Cys He Asp Wing He 35 40 45 Ser Gly Leu Wing Pro Gly Gln Gly Ser Val Gln Leu Asp Gly Thr Glu 50 55 60 He Leu Gly Thr Pro Val His Arg He Wing Arg Met Gly Val Gly Arg 65 70 75 80 Thr Phe Gln Thr Ala Ser Val Phe Glu Glu Leu Ser Val Leu Gln Asn 85 90 95 25 Leu Asp He Ala Cys Gly He His Arg Pro Leu Arg Ala Leu Leu Gly % á- -a 100 105 110 Val Arg His Arg He Asp Pro Arg He Glu His Wing Leu Glu Val Thr 115 120 125 Gly Leu Wing Asp Leu Val Asn Wing Gln Wing Gly Thr Leu Ser His Gly 130 135 140 Gln Lys Gln Trp Leu Glu He Wing Met Leu Leu Val Gln Asp Wing Gln 145 150 155 160 Val Leu Met Leu Asp Glu Pro Val Wing Gly Met Ser Glu Glu Glu Arg • 165 170 175 Val Wing Thr Gly Glu Leu Leu Gln Arg Val Wing Arg Gly Arg Val Val 180 185 190 Leu Val Val Glu His Asp Met Glu Phe Met Arg Arg Phe Wing Thr Arg 195 200 205 Val Thr Val Met Asn Arg Gly Thr He Leu Cys Glu Gly Ser Val Asp 210 215 220 Glu He Gln Wing Asn Pro Asp Val Gln Ser He Tyr Leu Gly Thr Ala 225 230 235 240 Gly Lys < 210 > 461 10 < 211 > 822 < 212 > DNA < 213 > Corynebacterium glutamicum • < 220 > < 221 > CDS < 222 > (101) .. (799) < 223 > RXA01222 < 400 > 461 aatcgcggca cgatcttgtg tgaggggtcg gtegatgaga ttcaggcgaa tccggatgtg 60 cagtccattt atttaggtac ggcagggaag tgagttagtc atg ttg gaa ate act 115 15 Met Leu Glu He Thr 1 5 aat ttg tgt ggt tat ggc cgc acg cag gta ctt cat tet ctt tea 163 Asn Leu Cys Wing Gly Tyr Gly Arg Thr Gln Val Leu His Ser Leu Ser 10 15 20 ate tcc acg age age aac ggc ate ctg tcg ate etc ggc falls aat ggc 211 He Ser Thr Ser Ser Asn Gly He Leu Ser He Leu Gly His Asn Gly 25 30 35 • gct ggt aaa tcc acc ttg ctg cga acc gcg gtg ggg ttg att aag ccg 259 Wing Gly Lys Ser Thr Leu Leu Arg Thr Wing Val Gly Leu He Lys Pro 40 45 50 act tcc gga gag gtc aaa ctt ttc ggc cag gat gtc acc tcg ttg tcc 307 20 Thr Ser Gly Glu Val Lys Leu Phe Gly Gln Asp Val Thr Ser Leu Ser 55 60 65 acg cat gag cga gta aag cgc gga atg gct tat gtg ccg cag ggc cag 355 Thr His Glu Arg Val Lys Arg Gly Met Wing Tyr Val Pro Gln Gly Gln 70 75 80 85 cag tet ttt acg cag ctt agt tgc atg gaa aat ttg cag gtg gta gcg 403 Gln Ser Phe Thr Gln Leu Ser Cys Met Glu Asn Leu Gln Val Val Wing 90 95 100 gat ctg cag gga cgt gtg ggc aag gca cgc ate gcg gag gcg ctt gat 451 Asp Leu Gln Gly Arg Val Gly Lys Ala Arg He Ala Glu Ala Leu Asp 105 110 115 cgc ttt ccg gcg ctg acc cag gtg ctg gac cgc ca gcc ggc ctg ttg 499 25 Arg Phe Pro Wing Leu Thr Gln Val Leu Asp Arg Gln Wing Gly Leu Leu 120 125 130 tcg ggt ggt cag cgt cag cag ctt gcc ate gcc cgc gcg ctg ate acg 547 Ser Gly Gly Gln Arg Gln Gln Leu Wing He Wing Arg Ala Leu He Thr 135 140 145 gcg cca aag ctt ttg ctt etc gac gaa ccc acc gag ggt att cag ect 595 Wing Pro Lys Leu Leu Leu Asp Glu Pro Thr Glu Gly He Gln Pro 150 155 160 165 tcg gtg gtt gct gaa att cag cag acc ate ate gat ttg gct aag gac 643 Val Val Ala Gllu He Gln Gln Thr He He Asp Leu Ala Lys Asp 170 175 180 ggc atg age att gtc ctg gtg gag caa aac att ggt ttt gca ttg gat 691 Gly Met Ser He Val Leu Val Glu Gln Asn He Gly Phe Wing Ala Leu Asp 185 190 195 gct gca here age tac gcc att gtg gcg cgt ggt cag gtc gtg gaa tcg 739 Wing Wing Thr Ser Tyr Wing He Val Wing Arg Gly Gln Val Val Glu Ser 200 205 210 gga ca ggc gct gaa acc action gca gag aag cag act aaa gtg cgg gaa 787 Gly Gln Gly Wing Glu Thr Thr Wing Glu Lys Gln Thr Lys Val Arg Glu 215 220 225 tet cta gca ate tagcggctgt ggatagcgtt ttg 822 Ser Leu Wing He 230 < 210 > 462 < 211 > 233 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 462 Met Leu Glu He Thr Asn Leu Cys Wing Gly Tyr Gly Arg Thr Gln Val 1 5 10 15 Leu His Ser Leu Be Ser Thr Ser Being Asn Gly He Leu Ser He 20 25 30 Leu Gly His Asn Gly Wing Gly Lys Ser Thr Leu Leu Arg Thr Wing Val 35 40 45 Gly Leu He Lys Pro Thr Ser Gly Glu Val Lys Leu Phe Gly Gln Asp 50 55 60 Val Thr Ser Leu Ser Thr His Glu Arg Val Lys Arg Gly Met Wing Tyr 65 70 75 80 Val Pro Gln Gly Gln Gln Ser Phe Thr Gln Leu Ser Cys Met Glu Asn 85 90 95 Leu Gln Val Val Wing Asp Leu Gln Gly Arg Val Gly Lys Wing Arg He 100 105 110 Wing Glu Wing Leu Asp Arg Phe Pro Wing Leu Thr Gln Val Leu Asp Arg 115 120 125 Gln Wing Gly Leu Leu Gly Gly Gln Arg Gln Gln Leu Wing Wing 130 135 140 Arg Ala Leu He Thr Wing Pro Lys Leu Leu Leu Leu Asp Glu Pro Thr 145 150 155 160 Glu Gly He Gln Pro Ser Val Val Wing Glu He Gln Gln Thr He He 165 170 175 Asp Leu Wing Lys Asp Gly Met Ser He Val Leu Val Glu Gln Asn He 180 185 190 Gly Phe Wing Leu Asp Wing Wing Thr Ser Tyr Wing He Val Wing Arg Gly 195 200 205 Gln Val Val Glu Ser Gly Gln Gly Wing Glu Thr Thr Wing Glu Lys Gln 210 215 220 Thr Lys Val Arg Glu Ser Leu Wing He 225 230 <; 210 > 463 < 211 > 1005 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > • < 221 > CDS < 222 > (101) .. (982) < 223 > RXA01219 < 400 > 463 caccatttgg, gaaaccgatt cecea, gttga tecggaccca tacttgti Ctt icctatgactg 60 ggc, caagacc, accgctgcga crttectaaga gataaaaatc atg gac att tta etc. 115 Met Asp He Leu Leu 1 5 aat cag etc gta gcc ggg ctt tea gtt gga tcg gtc ctt cta ttg gtc 163 Asn Gln Leu Val Wing Gly Leu Ser Val Gly Ser Val Leu Leu Leu Val 10 10 15 20 gca gtg gga ttg tea ctg acc ttt gga cag atg ggc gtt att aat atg 211 Wing Val Gly Leu Ser Leu Thr Phe Gly Gln Met Gly Val He Asn Met 25 30 35 • gcg falls gga gag ttc att gg gc gca gc gca tac acc gca tat gtg gtg 259 Wing His Gly Glu Phe He Met Val Gly Wing Tyr Thr Wing Tyr Val Val 40 45 50 cag ctg gtc gtc ggt tet gcc ggt tta tcc cta ctg ate age att ccg 307 Gln Leu Val Val Gly Ser Wing Gly Leu Ser Leu Leu He Ser He Pro 55 60 65 ctg gcc ttt att ate ggt ggg ctt ttc gga gtt etc etc gaa cata ttc 355 Leu Ala Phe He He Gly Gly Leu Phe Gly Val Leu Leu Glu Gln Phe 15 70 75 80 85 ctg ctg aag tat ctt tat drops agg cca cta gac acg ctg ctg gcc here 403 Leu Leu Lys Tyr Leu Tyr Hi s Arg Pro Leu Asp Thr Leu Leu Wing Thr 90 95 100 ttc ggt gtc gtt ttg ate ctt cag cg gc cg aga att ttc gga 451 Phe Gly Val Gly Leu He Leu Gln Gln Leu Ala Arg Asn He Phe Gly 105 110 115 gct ccc gca gtg gat gtc agg gca ccg gaa ttt etc cgc gga aac gtc 499 Wing Pro Wing Val Asp Val Arg Wing Pro Glu Phe Leu Arg Gly Asn Val • 120 125 130 gaa gtt cta ggc gtc ttg gtg ccg acc gcg cga cta ct cta tc cc cg gg 547 Glu Val Leu Gly Val Leu Val Pro Thr Wing Arg Leu Phe He Leu Wing 20 135 140 145 ctg gcc ate gca tea gtg act gca cta gct gtg ttc cta aat cgc act 595 Leu Ala He Ala Ser Val Thr Ala Leu Ala Val Phe Leu Asn Arg Thr 150 155 160 165 gcc tgg ggc cga cgc ate cgc gcc gtg gtt ctg aac cgc gac etc gcg 643 Wing Trp Gly Arg Arg He Arg Ala Val Val Leu Asn Arg Asp Leu Wing 170 175 180 gaa acc gca ggt att gat ac cg gct act gac cga atg acg ttc ttt 691 Glu Thr Wing Gly He Asp Thr Arg Wing Thr Asp Arg Met Thr Phe Phe 185 190 195 gtg ggc tcc ggt ctt gcc gga ate gcc ggg gta gct ate here ttg att 739 Val Gly Ser Gly Leu Wing Gly He Wing Gly Val Wing He Thr Leu He 25 200 205 210 - iTimÉBMftr nUJílt ggc gcg acc ggc ccc acc ate ggt cag aac tac ate gtg gat gcc ttc 787 Gly Wing Thr Gly Pro Thr He Gly Gln Asn Tyr He Val Asp Wing Phe 215 220 225 ctt gtt gtt gcc gcc ggt ggc ate ggc cgg gtg aag ggc gct gtg ate 835 Leu Val Val Wing Wing Gly Gly He Gly Arg Val Lys Gly Wing Val He 230 235 240 245 atg gct ttc gtg ctg gga att act gca ttc gtg gaa tat acg here 883 Met Wing Phe Val Leu Gly He Thr Gln Wing Phe Val Glu Tyr Thr Thr 250 255 260 • ggt gcg age ate gcg aag ttc ate gta etc ate gct gtt gtt gcc ttc 931 Gly Wing Be He Wing Lys Phe He Val Leu He Wing Val Val Wing Phe 265 270 275 ctg cag ttt agg ect ca gga etc ttc ca ac acc ac act agg age etc 979 Leu Gln Phe Arg Pro Gln Gly Leu Phe Gln Thr Gln Thr Arg Ser Leu 280 285 290 gta tgagcactca actcaagctg aag 1005 Val < 210 > 464 < 211 > 294 10 < 212 > PRT < 213 > Corynebacterium glutamicum • < 400 > 464 Met Asp He Leu Leu Asn Gln Leu Val Wing Gly Leu Ser Val Gly Ser 1 5 10 15 Val Leu Leu Leu Val Wing Val Gly Leu Ser Leu Thr Phe Gly Gln Met 20 25 30 Gly Val He Asn Met Wing His Gly Glu Phe He Met Val Gly Wing Tyr 35 40 45 Thr Wing Tyr Val Val Gln Leu Val Val Gly Ser Wing Gly Leu Ser Leu 15 50 55 60 Leu He Ser He Pro Leu Wing Phe He He Gly Gly Leu Phe Gly Val 65 70 75 80 Leu Leu Glu Gln Phe Leu Leu Lys Tyr Leu Tyr His Arg Pro Leu Asp 85 90 95 Thr Leu Leu Wing Thr Phe Gly Val Gly Leu He Leu Gln Gln Leu Wing 100 105 110 Arg Asn He Phe Gly Ala Pro Wing Val Asp Val Arg Ala Pro Glu Phe 115 120 125 • Leu Arg Gly Asn Val Glu Val Leu Gly Val Leu Val Pro Thr Ala Arg 130 135 140 Leu Phe He Leu Ala Leu Ala He Ala Ser Val Thr Ala Leu Ala Val 20 145 150 155 160 Phe Leu Asn Arg Thr Wing Trp Gly Arg Arg He Arg Wing Val Val Leu 165 170 175 Asn Arg Asp Leu Wing Glu Thr Wing Gly He Asp Thr Arg Wing Thr Asp 180 185 190 Arg Met Thr Phe Phe Val Gly Ser Gly Leu Wing Gly He Wing Gly Val 195 200 205 Wing He Thr Leu He Gly Wing Thr Gly Pro Thr He Gly Gln Asn Tyr 210 215 220 He Val Asp Wing Phe Leu Val Val Wing Wing Gly Gly He Gly Arg Val 225 230 235 240 Lys Gly Wing Val He Met Wing Phe Val Leu Gly He Thr Gln Wing Phe 25 245 250 255 Val Glu Tyr Thr Thr Gly Ala Ser He Wing Lys Phe He Val Leu He 260 265 270 Wing Val Val Wing Phe Leu Gln Phe Arg Pro Gln Gly Leu Phe Gln Thr 275 280 285 Gln Thr Arg Ser Leu Val 290 < 210 > 465 < 211 > 1200 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1177) < 223 > RXA01220 < 400 > 465 caggtgcgag icatc < gcgaag ttcatiegtac tcatcgictgt tgttgeette ictgcagttta 60 ggcctcaagg, actcttccaa acccaaacta gg; agectegt atg age act caa etc 115 10 Met Ser Thr Gln Leu 1 5 aag aag aag aac cc c g a g aa g aa g aa g aa tc ac a cc a g a ct gtc 163 Lys Lys Lys Pro Lys Lys Lys Lys Thr Thr Pro Lys Leu Ser Val • 10 15 20 gta aat gct ccc acg cgc act gcg gcg gt ggc ctg gcc gcg etc 211 Val Asn Ala Pro Thr Leu Arg Thr Ala Ala Leu Gly Leu Ala Ala Leu 25 30 35 gct gcg gta ttg ctg tgc gcc ccg etc ttt tta tcc here ttc cag ctg 259 Ala Ala Val Leu Leu Cys Ala Pro Leu Phe Leu Ser Thr Phe Gln Leu 40 45 50 acg ttg atg tcg cgc ttg gtg tgt tat gcg ate gtc gca gtc ggc ate 307 15 Thr Leu Met Ser Arg Leu Val Cys Tyr Wing He Val Wing Val Gly He 55 60 65 ggg ctg gcg tgg ggc aga ggc ggc atg etc acg ctg ggg ca ggc gtg 355 Gly Leu Wing Trp Gly Arg Gly Gly Met Leu Thr Leu Gly Gln Gly Val 70 75 80 85 ttc ttt gga ate ggc gcg tac ate atg gcc atg fall atg ctg tac age 403 Phe Phe Gly He Gly Wing Tyr He Met Wing Met His Met Leu Tyr Ser 90 95 100 gat tcg cag att ttt ggg acc here gtt ccg caà tgg tgg tcc att ttt 451 • Asp Ser Gln He Phe Gly Thr Thr Val Pro Gln Trp Trp Ser He Phe 105 110 115 gcc aac ccg gca gtc gca etc ate gca gtt gtg gcg ctt ccc ggc ate 499 20 Wing Asn Pro Wing Val Wing Leu He Wing Val Val Wing Leu Pro Gly He 120 125 130 gtg gct ttt gtg etc ggc ttc tcc att ttc aaa cga cgc ate aaa ggc 547 Val Ala Phe Val Leu Gly Phe Ser He Phe Lys Arg Arg He Lys Gly 135 140 145 gcc tac ttt gcc ate gtg aac ca gcg etc gcc gca gct gtt gtg gtg 595 Wing Tyr Phe Wing He Val Asn Gln Wing Leu Wing Wing Wing Val Val Val 150 155 160 165 ttg ctg gtc gga caá ca gt tcc ctt gga ggt tcc aat ggt ctt tcc 643 Leu Leu Val Gly Gln Gln Asp Ser Leu Gly Gly Ser Asn Gly Leu Ser 170 175 180 gga ttt cga tcg ttc atg ggt ttt gcc gtc tac gac ccc ate aac cgc 691 25 Gly Phe Arg Ser Phe Met Gly Phe Wing Val Tyr Asp Pro He Asn Arg 185 190 195 tet atg ttt tac tc gtg gtg gtt gtt etc ttg gct ttg gtg gct gct 739 He Met Phe Tyr Phe Thr Wing Val Gly Val Leu Leu Wing Leu Val Wing 200 205 210 ate tea tat tgg etc atg cgc age cgc tat gga gaa ctg etc gtg gcc 787 He Be Tyr Trp Leu Met Arg Ser Arg Tyr Gly Glu Leu Leu Val Wing 215 220 225 aga gat gaga gaa gag cgc gtc cga ttc etc gga tat gat ccc gca 835 Thr Arg Asp Wing Glu Glu Arg Val Arg Phe Leu Gly Tyr Asp Pro Wing • 230 235 240 245 ttg tie aaa acc gcc gca tat gtc att gct gcg atg att gcc gga ate Leu He Lys Thr Ala Ala Tyr Val He Ala Ala Ala He Ala Gly He 250 255 260 gcc gga gcg ctg ttc gtg ccg ate gtg ggc ate att tea ccc gca gaa 931 Ala Gly Ala Leu Phe Val Pro He Val Gly He He Ser Pro Ala Glu 265 270 275 ate ggc gtg gtg cca tea ate gtg ttc gtg ate gcc gtc gcc gct ggt ggt 979 He Gly Val Val Pro Ser He Val Phe Val He Ala Val Ala Wing Gly 280 285 290 ggc agg gca tcc cta tcc gct ccc gta gtt gcc gcg ctg gtg ctg gcc 1027 10 Gly Arg Ala Ser Leu Phe Gly Pro Val Val Gly Ala Leu Val Leu Gly 295 300 305 tgg gtg gaa tcc here ctt gct cact act ttc ccc age atg tgg tcc tat 1075 Trp Val Glu Ser Thr Leu Wing Gln Thr Phe Pro Ser Met Trp Ser Tyr 310 315 320 325 • ttc cag ggt gcg ate ctg gtt etc gtg ate gtg ttg ctg ccg ggc gga 1123 Phe Gln Gly Ala He Leu Val Leu Val He Val Leu Leu Pro Gly Gly 330 335 340 att gct tea att aaa ctt tcc gcg etc aaa aat aag gcc agg aag gcc 1171 He Wing To Be He Lys Leu To Be Wing Leu Lys Asn Lys Wing Arg Lys Wing 345 350 355 acc tea tgagccttaa aatcaccaac ct: c 1200 15 Thr Ser < 210 > 466 < 211 > 359 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 466 Met Ser Thr Gln Leu Lys Leu Lys Lys Pro Wing Lys Lys Lys Thr Thr • 1 5 10 15 Pro Lys Leu Ser Val Val Asn Wing Pro Thr Leu Arg Thr Wing Ala Leu 20 20 25 30 Gly Leu Wing Wing Leu Wing Wing Val Leu Leu Cys Wing Pro Leu Phe Leu 35 40 45 Be Thr Phe Gln Leu Thr Leu Met Ser Arg Leu Val Cys Tyr Wing He 50 55 60 Val Wing Val Gly He Gly Leu Wing Trp Gly Arg Gly Gly Met Leu Thr 65 70 75 80 Leu Gly Gln Gly Val Phe Phe Gly He Gly Wing Tyr He Met Wing Met 85 90 95 His Met Leu Tyr Ser Asp Ser Gln He Phe Gly Thr Thr Val Pro Gln 100 105 110 Trp Trp Ser He Phe Wing Asn Pro Ala Val Ala Leu He Ala Val Val 25 115 120 125 J ii - », *.» £ l »lü» Wing Leu Pro Gly He Val Wing Phe Val Leu Gly Phe Ser He Phe Lys 130 135 140 Arg Arg He Lys Gly Wing Tyr Phe Wing He Val Asn Gln Wing Leu Wing 145 150 155 160 Wing Wing Val Val Leu Leu Val Gly Gln Gln Asp Ser Leu Gly Gly 165 170 175 Being Asn Gly Leu Being Gly Phe Arg Being Phe Met Gly Phe Wing Val Tyr 180 185 190 Asp Pro He Asn Arg He Met Phe Tyr Phe Thr Ala Val Gly Val Leu 195 200 205 Leu Ala Leu Val Ala He Ser Tyr Trp Leu Met Arg Ser Arg Tyr Gly 210 215 220 Glu Leu Leu Val Wing Thr Arg Asp Wing Glu Glu Arg Val Arg Phe Leu 225 230 235 240 Gly Tyr Asp Pro Wing Leu He Lys Thr Wing Wing Tyr Val He Wing Wing 245 250 255 Met He Wing Gly He Wing Wing Wing Leu Phe Val Pro He Val Gly He 260 265 270 He Ser Pro Wing Glu He Gly Val Val Pro Ser He Val Phe Val He 275 280 285 Wing Val Wing Wing Gly Gly Arg Wing Leu Phe Gly Pro Val Val Gly 290 295 300 Wing Leu Val Leu Gly Trp Val Glu Ser Thr Leu Wing Gln Thr Phe Pro 305 310 315 320 Ser Met Trp Ser Tyr Phe Gln Gly Wing He Leu Val Leu Val He Val 325 330 335 Leu Leu Pro Gly Gly He Wing Be He Lys Leu Be Wing Leu Lys Asn 340 345 350 Lys Wing Arg Lys Wing Thr Ser 355 <; 210 > 467 < 211 > 876 < 212 > DNA < 213 > Corynebact: erium gl .utamicu < 220 > < 221 > CDS < 222 > (101) .. (853) < 223 > RXA00091 < 400 > 467 tcatgaacca cgtgttccgc gcacaaggcg tcgtgtccat cattattgag atggtcggcg 60 gtaccgtctt cctcatcgtc atcctcagaa agggcagact gtg att acg tta act 115 Val He Thr Leu Thr 1 5 aat gtc cgc aag gaa tac tcc age gac gtt gcc ate ggc ccc gtc aac 163 Asn Val Arg Lys Glu Tyr Ser Ser Asp Val Wing He Gly Pro Val Asn 10 15 20 ctt gag ate cca gcc ggc ggc ate acc gcg ttg gtc ggc cca aac ggt 211 Leu Glu He Pro Wing Gly Gly He Thr Wing Leu Val Gly Pro Asn Gly 25 30 35 gca ggc aag tea here ctg etc acc atg ate ggt cga etc etc ggc ate 259 Wing Gly Lys Ser Thr Leu Leu Thr Met He Gly Arg Leu Le Gly He 40 45 50 gat gaa ggc aac ate acc gta gcc tcc tac gat gtc acc tea acc gca 307 Asp Glu Gly Asn He Thr Val Wing Ser Tyr Asp Val Thr Ser Thr Ala , * .A-- -a 55 60 65 tcc aaa gat ctg gcc aag ate ate tcc ate ctg cgc cag gaa aac falls 355 Ser Lys Asp Leu Ala Lys He He Ser He Leu Arg Gln Glu Asn His 70 75 80 85 ttt gtt acc aag ctg acc gtg cgc cag etc gta ggt ttc gga cgc ttc 403 Phe Val Thr Lys Leu Thr Val Arg Gln Leu Val Gly Phe Gly Arg Phe 90 95 100 cca tat age aag ggc cgg ctg ac ga gaa gac gag gga ate ate tcc 451 Pro Tyr Ser Lys Gly Arg Leu Thr Glu Glu Asp Glu Gly He He Ser • 105 110 115 cgc tac ate gac ttc ttc aat etc acc gaa etc gaa gac cgc tac etc 499 Arg Tyr He Asp Phe Phe Asn Leu Thr Glu Leu Glu Asp Arg Tyr Leu 120 125 130 gac cag ctt tcc ggc ggc cag cgc cag cgc gcc tat gtc gcc atg gtg 547 Asp Gln Leu Ser Gly Gly Gln Arg Gln Arg Ala Tyr Val Ala Met Val 135 140 145 ctg tgc ca gag acg gac tac gtg ctt etc gac gaa ccc etc aac aat 595 Leu Cys Gln Glu Thr Asp Tyr Val Leu Leu Asp Glu Pro Leu Asn Asn 150 155 160 165 ctt gat ate gca falls tcg gtg gaa atg atg aaa falls etc gag aat gct 643 Leu Asp He Ala His Ser Va Glu Met Met Lys His Leu Glu Asn Wing 10 170 175 180 gca gcc cata ttt ggc cgc acc ate ate gtg gtt ctt cae gac ate aac 691 Ala Ala Gln Phe Gly Arg Thr He He Val Val Leu His Asp He Asn 185 190 195 ttc gcc gcg cgc tac gcc gat tac ate gtg gcc gta aag falls gga atg 739 phe wing wing arg tyr wing asp tyr he val wing val lys his gly met 200 205 210 ate gaa aaa gag gga here ect gaa cag ate atg aaa aac gag ate ctt 787 He Glu Lys Glu Gly Thr Pro Glu Gln He Met Lys Asn Glu He Leu 215 220 225 tea gaa ate ttc aat here gag ate gaa gtt att gaa gga cca fall ggc 835 Val He Glu Gly 15 Ser Glu He Phe Asn Thr Glu He Glu Pro His Gly 230 235 240 245 aag att gct tgc tac falls taaatgaaga gaaataagcc gac 876 Lys He Ala Cys Tyr His 250 < 210 > 468 < 211 > 251 < 212 > PRT • < 213 > Corynebacterium glutamicum < 400 > 468 Val He Thr Leu Thr Asn Val Arg Lys Glu Tyr Ser Ser Asp Val Wing 20 1 5 10 15 He Gly Pro Val Asn Leu Glu Pro Pro Wing Gly Gly He Thr Ala Leu 20 25 30 Val Gly Pro Asn Gly Wing Gly Lys Ser Thr Leu Leu Thr Met He Gly 35 40 45 Arg Leu Leu Gly He Asp Glu Gly Asn He Thr Val Wing Ser Tyr Asp 50 55 60 Val Thr Ser Thr Wing Ser Lys Asp Leu Wing Lys He He Ser He Leu 65 70 75 80 Arg Gln Glu Asn His Phe Val Thr Lys Leu Thr Val Arg Gln Leu Val 85 90 95 25 Gly Phe Gly Arg Phe Pro Tyr Ser Lys Gly Arg Leu Thr Glu Glu Asp 100 105 110 Glu Gly He He Ser Arg Tyr He Asp Phe Phe Asn Leu Thr Glu Leu 115 120 125 Glu Asp Arg Tyr Leu Asp Gln Leu Ser Gly Gln Arg Gln Arg Ala 130 135 140 Tyr Val Ala Met Val Leu Cys Gln Glu Thr Asp Tyr Val Leu Leu Asp 145 150 155 160 Glu Pro Leu Asn Asn Leu Asp He Wing His Ser Val Glu Met Met Lys 165 170 175 His Leu Glu Asn Wing Wing Gln Phe Gly Arg Thr He He Val Val 180 185 190 Leu His Asp He Asn Phe Wing Wing Arg Tyr Wing Asp Tyr He Val Wing 195 200 205 Val Lys His Gly Met He Glu Lys Glu Gly Thr Pro Glu Gln He Met 210 215 220 Lys Asn Glu He Leu Ser Glu He Phe Asn Thr Glu He Glu Val He 225 230 235 240 Glu Gly Pro His Gly Lys He Ala Cys Tyr His 245 250 10 < 210 > 469 < 211 > 692 < 212 > DNA < 213 > Corynebacterium glutamicum • < 220 > < 221 > CDS < 222 > (79). . (669) < 223 > RXA00228 < 400 > 469 ccgcatggca tccgccgaaa gaattcccct ceggaggaat ggcacgcctc atgggagaac 60 15 gcatcggcaa aaactgac atg cgc gac etc cgc tcc atg ate ggc gtc age 111 Met Arg Asp Leu Arg Ser Met He Gly Val Ser 1 5 10 tcc tcc gca tta ggc aac cga ate ccc tcc gaa gaa aaa gtc tet gac 159 Be Being Wing Leu Gly Asn Arg He Pro Ser Glu Glu Lys Val Ser Asp 15 20 25 cta gtc ate tcc gca ggc tac gca ate etc ggc cgc tgg cgc gaa gac 207 Leu Val He Ser Ala Gly Tyr Ala He Leu Gly Arg Trp Arg Glu Asp 30 35 40 • tac gac gaa atg gac ttc gga ca gcc acc gaa ate etc gaa ca gtc 255 Tyr Asp Glu Met Asp Phe Gly Gln Wing Thr Glu He Leu Glu Gln Val 45 50 55 20 gga gcc atg falls cta gcc gac cgc acc tgg gga acc etc tcc gaa ggc 303 Gly Ala Met His Leu Wing Asp Arg Thr Trp Gly Thr Leu Ser Glu Gly 60 65 70 75 gaa cgc aaa cga gtc ctg gtc gca cgc gca etc atg acc aac ccg gaa 351 Glu Arg Lys Arg Val Leu Val Wing Arg Wing Leu Met Thr Asn Pro Glu 80 85 90 etc etc tying ctt gac gaca cca acc gca gga atg gac etc ggc gga cgc 399 Leu Leu He Leu Asp Glu Pro Thr Wing Gly Met Asp Leu Gly Gly Arg 95 100 105 gaa gac etc gtc gcc tac etc gga gaa etc gcc atc gac cca gac gca 447 Glu Asp Leu Val Gly Tyr Leu Gly Glu Leu Wing Met Asp Pro Asp Wing 110 115 120 25 ect gcc ate gtc atg ate acc fall falls gtc gaa gaa ate ccc gcc gga 495 Pro Wing He Val Met He Thr His His Val Glu Glu He Pro Ala Gly 125 130 135 ttc acc drops gca atg etc etc gac gaa ggt gaa ate gta gcc ca ggc 543 Phe Thr His wing Met Leu Leu Asp Glu Gly Glu He Val Wing Gln Gly 140 145 150 155 ctg ate aac acc gtc atg here aac gag aac cta tcc aaa gca ttc falls 591 Leu He Asn Thr Val Met Thr Asn Glu Asn Leu Ser Lys Ala Phe His 160 165 170 cag cca ate ca gta gac cgc ate ggg gaa cgc tac ttt gcc cgc cgt 639 Gln Pro He Gln Val Asp Arg He Gly Glu Arg Tyr Phe Wing Arg Arg 175 180 185 gtg aga acc gcc agg agt cat agg gct cag taggtttttt ggagttgtgg 689 Val Arg Thr Ala Arg Ser His Arg Ala Gln 190 195 gcc 692 < 210 > 470 < 211 > 197 < 212 > PRT < 213 > Corynebacterium glutamicum 10 < 400 > 470 Met Arg Asp Leu Arg Being Met He Gly Val Being Ser Wing Leu Gly 1 5 10 15 Asn Arg He Pro Being Glu Glu Lys Val Being Asp Leu Val He Being Wing • 20 25 30 Gly Tyr Wing He Leu Gly Arg Trp Arg Glu Asp Tyr Asp Glu Met Asp 35 40 45 Phe Gly Gln Wing Thr Glu He Leu Glu Gln Val Gly Wing Met His Leu 50 55 60 Wing Asp Arg Thr Trp Gly Thr Leu Ser Glu Gly Glu Arg Lys Arg Val 65 70 75 80 15 Leu Val Ala Arg Ala Leu Met Thr Asn Pro Glu Leu Leu He Leu Asp 85 90 95 Glu Pro Thr Ala Gly Met Asp Leu Gly Gly Arg Glu Asp Leu Val Gly 100 105 110 Tyr Leu Gly Glu Leu Ala Met Asp Pro Asp Ala Pro Wing He Val Met 115 120 125 He Thr His His Val Glu Glu He Pro Wing Gly Phe Thr His Wing Met 130 135 140 Leu Leu Asp Glu Glu Glu He Val Wing Gln Gly Leu He Asn Thr Val • 145 150 155 160 Met Thr Asn Glu Asn Leu Ser Lys Wing Phe His Gln Pro He Gln Val 165 170 175 20 Asp Arg He Gly Glu Arg Tyr Phe Wing Arg Arg Val Arg Thr Wing Arg 180 185 190 Ser His Arg Ala Gln 195 < 210 > 471 < 211 > 813 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS 25 < 222 > (101) (790) . ^ & i i. < 223 > RXA00346 < 400 > 471 atctatgaga cccctcaaaa cacegagaat ttcctcgatg cattcaccaa ggeagttgat 60 gatctcaccg ctgccactaa ccaggtttag aattatttaa atg ctg ttg act ttc 115 Met Leu Leu Thr Phe 1 5 aat gat gct gcg gtg gat ccc etc tgg agg ggc ctg aat tta gag etc 163 Asn Asp Ala Ala Val Asp Pro Leu Trp Arg Gly Leu Asn Leu Glu Leu 10 15 20 cga cag ggg gaa ttt ctt gcg gtt tta ggc ccc aac ggc gtg gga aaa 211 Arg Gln Gly Glu Phe Leu Wing Val Leu Gly Pro Asn Gly Val Gly Lys 25 30 35 tcc acg etc ate ggt acg att ttg ggc acc cga aaa etc acc falls ggt 259 Ser Thr Leu He Gly Thr He Leu Gly Thr Arg Lys Leu Thr His Gly 40 45 50 tcg gtt aaa act gat gcc cgg gtg ggt tat att ccg caá caga cga att 307 Ser Val Lys Thr Asp Wing Arg Val Gly Tyr He Pro Gln Gln Arg He 55 60 65 ttc gat gtc ccg ttg cgt gcc cgc gat atg gtt tcg ctg tcc gcg gcg 355 10 Phe Asp Val Pro Leu Arg Ala Arg Asp Met Val Ser Leu Ser Wing Wing 70 75 80 85 cat ggc gtg gtt tcc aaa agg gga ccc gcg aag ggt gac gtc gat aag 403 His Gly Val Val Ser Lys Arg Gly Pro Ala Lys Gly Asp Val Asp Lys • 90 95 100 ctt ctt gcc cgc gg ggc gct tcc gga ate gcc gat cgc cgc gtc ggc 451 Leu Leu Wing Arg Val Gly Wing Ser Gly He Wing Asp Arg Arg Val Gly 105 110 115 gag etc tcc ggc ggg cag cag cag etc gtc cgc ca gcc cag gcc ctt 499 Glu Leu Ser Gly Gly Gln Gln Gln Leu Val Arg Gln Ala Gln Ala Leu 120 125 130 gcc acg cgc ccg cata tta ttg ctt gcc gac gaa ccc etc etc age ctt 547 Wing Thr Arg Pro Gln Leu Leu Leu Wing Asp Glu Pro Leu Leu Ser Leu 15 135 140 145 gac ccc ggc gtc gcg cag cgc acg gtg tcc cta ttt ggt gaa ttg aag 595 Asp Pro Gly Val Ala Gln Arg Thr Val Ser Leu Phe Gly Glu Leu Lys 150 155 160 165 gcc gaa ggc gtc ggc gtt gtt gtg gtc acc fall gat gtc aat cca cta 643 wing Glu Gly Val Gly Val Val Val Val Thr His Asp Val Asn Pro Leu 170 175 180 atg ggc ctg gta gat cgc att ttg tac etc gcc ccc aac ggc falls acc 691 • Met Gly Leu Val Asp Arg He Leu Tyr Leu Pro Wing Asn Gly His Thr 185 190 195 ate ggc acg gtt ggc gat gtc atg cag tcc gaa aaa etc age gaa etc 739 20 He Gly Thr Val Gly Asp Val Met Gln Ser Glu Lys Leu Ser Glu Leu 200 205 210 tac aac gca ccc gtc acg gtg gct cgc ate aac gac aga ate gtg gtg 787 Tyr Asn Ala Pro Val Thr Val Ala Arg He Asn Asp Arg He Val Val 215 220 225 gtt taagtggatc tatccacctg gct 813 Val 230 < 210 > 472 < 211 > 230 < 212 > PRT 25 < 213 > Corynebacterium glutamicum < 400 > 472 Met Leu Leu Thr Phe Asn Asp Ala Ala Val Asp Pro Leu Trp Arg Gly 1 5 10 15 Leu Asn Leu Glu Leu Arg Gln Gly Glu Phe Leu Wing Val Leu Gly Pro 20 25 30 Asn Gly Val Gly Lys Ser Thr Leu He Gly Thr He Leu Gly Thr Arg 35 40 45 Lys Leu Thr His Gly Ser Val Lys Thr Asp Ala Arg Val Gly Tyr He 50 55 60 Pro Gln Gln Arg He Phe Asp Val Pro Leu Arg Ala Arg Asp Met Val 65 70 75 80 Ser Leu Be Ala Ala His Gly Val Val Ser Lys Arg Gly Pro Ala Lys 85 90 95 Gly Asp Val Asp Lys Leu Leu Wing Arg Val Gly Wing Ser Gly He Wing 100 105 110 Asp Arg Arg Val Gly Glu Leu Ser Gly Gln Gln Gln Gln Leu Val Arg 115 120 125 Gln Ala Gln Ala Leu Ala Thr Arg Pro Gln Leu Leu Leu Ala Asp Glu 130 135 140 Pro Leu Leu Ser Leu Asp Pro Gly Val Wing Gln Arg Thr Val Ser Leu 145 150 155 160 Phe Gly Glu Leu Lys Wing Glu Gly Val Gly Val Val Val Val Thr His 165 170 175 Asp Val Asn Pro Leu Met Gly Leu Val Asp Arg He Leu Tyr Leu Wing 180 185 190 Pro Asn Gly His Thr He Gly Thr Val Gly Asp Val Met Gln Ser Glu 195 200 205 Lys Leu Ser Glu Leu Tyr Asn Ala Pro Val Thr Val Ala Arg He Asn 210 215 220 Asp Arg He Val Val Val 225 230 < 210 > 473 < 211 > 433 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (433) < 223 > RXA00524 < 400 > 473 tcctcggcac ccgctacccc gtcggagttg tcaccggcgc attcggcgcc ccattcctta 60 tctatttact cattcgttcc aaccgcgcgg gagtaaccct gtg acc acc aac cat 115 Val Thr Thr Asn His 1 5 cac cta tcc gcc gaa gaa att tcc ctg gcg tac ggc gag cgc acc ate 163 Gln Leu Ser Ala Glu Glu He Ser Leu Ala Tyr Gly Glu Arg Thr He 10 15 20 ate gat tcg etc age gtc gac ate gtc ccc ggc aaa ate acc tcc ate 211 He Asp Ser Leu Ser Val Asp He Val Pro Gly Lys He Thr Ser He 25 30 35 gtc ggc ccc aac gga tgc ggc aaa tea acg ctg cgc cgc gcc ttt gcg 259 Val Gly Pro Asn Gly Cys Gly Lys Ser Thr Leu Leu Arg Wing Phe Wing 40 45 50 cgc etc ctt aaa ect age gcc ggg ca gcg ctt ate gac gcc ccc crash 307 Arg Leu Leu Lys Pro Be Wing Gly Gln Wing Leu He Asp Wing His Pro 55 60 65 ctt ect tea ctg cca ggc aaa gaa cta gct cgc atg etc ggg ctg tta 355 Leu Pro Ser Leu Pro Gly Lys Glu Leu Ala Arg Met Leu Gly Leu Leu 70 75 80 85 ccg cacc tcc ccc acc gga ect gaa ggc ate gtc gtc gcc gac gtg 403 Pro Gln Ser Pro Thr Gly Pro Glu Gly He Val Val Wing Asp Leu Val 90 95 100 ggc cgc ggc cgc falls ccc falls ca gga gga etc 433 Gly Arg Gly Arg His Pro His Gln Gly Leu 105 110 < 210 > 474 < 211 > 111 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 474 Val Thr Thr Asn His Gln Leu Ser Ala Glu Glu He Ser Leu Ala Tyr 1 5 10 15 Gly Glu Arg Thr He He Asp Ser Leu Ser Val Asp He Val Pro Gly 20 25 30 Lys He Thr Ser He Val Gly Pro Asn Gly Cys Gly Lys Ser Thr Leu 35 40 45 Leu Arg Ala Phe Ala Arg Leu Leu Lys Pro Be Wing Gly Gln Wing Leu 50 55 60 He Asp Wing His Pro Leu Pro Be Leu Pro Gly Lys Glu Leu Wing Arg 65 70 75 80 Met Leu Gly Leu Leu Pro Gln Ser Pro Thr Gly Pro Glu Gly He Val 85 90 95 Val Wing Asp Leu Val Gly Arg Gly Arg His Pro His Gln Gly Leu 100 105 110 < 210 > 475 < 211 > 900 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (877) < 223 > RXA01823 < 400 > 475 gcaacacgtt gatactgagc tgcacacgcc cgttggcctg gtgaccagtt tgctgggcgg 60 ggtgtatttg atgtggcttt tgagccgaaa ggaggcataa atg ctg cag gcg cat 115 Met Leu Gln Ala His 1 5 gat etc acg ctg agt tac ggc ggg cga aat att gta gaa ggg etc agt 163 Asp Leu Thr Leu Ser Tyr Gly Gly Arg Asn He Val Glu Gly Leu Ser 10 15 20 ctg gac ctt ccg gaa aga ggc etc age ate ate att ggc ccc aac gga 211 Leu Asp Leu Pro Glu Arg Gly Leu Ser He He He Gly Pro Asn Gly 25 30 35 tgc ggg aaa tea acc gtt ttg aaa gcg ttg ggc aga ctg ctg aaa cca 259 Cys Gly Lys Ser Thr Val Leu Lys Ala Leu Gly Arg Leu Leu Lys Pro . , Í • 40 45 50 caa ttg ggg aag ate acg cta ggt ggg cga gat att aka age atg ggc 307 Gln Leu Gly Lys He Thr Leu Gly Gly Arg Asp He Ser Ser Met Gly 55 60 65 acc aag cat gtg gcg aaa falls tie ggg gtg ctt ccg ca ccc cca tat 355 Thr Lys His Val Wing Lys His He Gly Val Leu Pro Gln Pro Pro Tyr 70 75 80 85 gcg ccc gat ggg gtg age gtc acg gag ctg gtc age cgc ggg cgg tat 403 Wing Pro Asp Gly Val Ser Val Thr Glu Leu Val Ser Arg Gly Arg Tyr 90 95 100 ccg falls caa cat ctg ctg tcg caa tgg tcg aaa gac gat gaa gcc att 451 Pro His Gln His Leu Leu Ser Gln Trp Ser Lys Asp Asp Glu Ala He 105 110 115 gtg gcg cgc tcg ctg gcg gaa gtc ggc atg falls cat cat gct gag cat 499 Val Ala Arg Ser Leu Ala Glu Val Gly Met His Thr His Ala Glu His 120 125 130 tta gtg tcg gaa ctt tea ggc ggc cag cgc caa cgg gcg tgg ate gcc 547 Leu Val Ser Glu Leu Ser Gly Gln Arg Gln Arg Ala Trp He Ala 135 140 145 atg gcg etc gct cag gaa here gac att ttg ctt etc gac gag ccc acc 595 Met Ala Leu Ala Gln Glu Thr Asp He Leu Leu Leu A sp Glu Pro Thr 150 155 160 165 acg ttc etc gac gta gcc falls ca ata tcc gtc etc gat tta tgc tcc 643 Thr Phe Leu Asp Val Wing His Gln He Ser Val Leu Asp Leu Cys Ser 170 175 180 gac ctg falls ca g ct ggt cgc acc ctg gcc att gtt cta fall gat ctg 691 Asp Leu His Gln Arg Gly Arg Thr Leu Wing He Leu Val Leu His Asp Leu 185 190 195 aac atg gct gg cgg tat gcc acc fall ate ate gcc atg cgg gac ggc 739 Asn Met Wing Ala Arg Tyr Ala Thr His He He Ala Met Arg Asp Gly 200 205 210 acc ate ate gac caa aaa gga ccc gaa gaa ata etc act aaa gcg ctg 787 Thr He He Asp Gln Gly Lys Pro Glu Glu He Leu Thr Lys Ala Leu 215 220 225 etc aaa gaa gtt ttt gac etc gac gca etc tether etc aaa gac ccc aac 835 Leu Lys Glu Val Phe Asp Leu Asp Ala Leu He Leu Lys Asp Pro Asn 230 235 240 245 aac ggc cga cca ccc etc gtg cct here gac agg aga aac tea 877 Asn Gly Arg Pro Leu He Val Pro Thr Asp Arg Arg Asn Ser 250 255 tgaaagaaac cgacaaccta ctg 900 < 210 > 476 < 211 > 259 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 476 Met Leu Gln Ala His Asp Leu Thr Leu Ser Tyr Gly Gly Arg Asn Hebrews 1 May 10 15 Val Glu Gly Leu Ser Leu Asp Leu Pro Glu Arg Gly Leu Ser He He 20 25 30 He Gly Pro Asn Gly Cys Gly Lys Ser Thr Val Leu Lys Wing Leu Gly 35 40 45 Arg Leu Leu Lys Pro Gln Leu Gly Lys He Thr Leu Gly Gly Arg Asp 50 55 60 He Be Ser Met Gly Thr Lys His Val Wing Lys His He Gly Val Leu . *. * «I ¿. 65 70 75 80 Pro Gln Pro Pro Tyr Ala Pro Asp Gly Val Ser Val Thr Glu Leu Val 85 90 95 Ser Arg Gly Arg Tyr Pro His Gln His Leu Leu Ser Gln Trp Ser Lys 100 105 110 Asp Asp Glu Ala He Val Ala Arg Ser Leu Ala Glu Val Gly Met His 115 120 125 Thr His Wing Glu His Leu Val Ser Glu Leu Ser Gly Gly Gln Arg Gln 130 135 140 Arg Wing Trp He Wing Met Wing Ala Leu Wing Gln Glu Thr Asp He Leu Leu 145 150 155 160 Leu Asp Glu Pro Thr Thr Phe Leu Asp Val Ala His Gln He Ser Val 165 170 175 Leu Asp Leu Cys Ser Asp Leu His Gln Arg Gly Arg Thr Leu Ala He 180 185 190 Val Leu His Asp Leu Asn Met Ala Ala Arg Tyr Ala Thr His He He 195 200 205 Wing Met Arg Asp Gly Thr He He Asp Gln Gly Lys Pro Glu Glu He 210 215 220 Leu Thr Lys Ala Leu Leu Lys Glu Val Phe Asp Leu Asp Ala Leu He 225 230 235 240 Leu Lys Asp Pro Asn Asn Gly Arg Pro Leu He Val Pro Thr Asp Arg 245 250 255 Arg Asn Ser < 210 > 477 < 211 > 906 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (883) < 223 > RXA02767 < 400 > 477 gggaaaacgt 'ttcctcgccg cccacagaal: cataaaaatt ttctgaggtt < gtcaitgggta 60 ccagtctaag < ccctcggedtt acgccagtaa ggtgtt; atg cgc gaa cta AECE gca 115 Met Ala Leu Arg Glu aac atg May 1 etc gcc ggc gtc acc gtg cgg cgc ggc gag ctt ttg aaa etc 163 Leu Asn Met Wing Gly Val Thr Val Arg Arg Gly Glu Lys Leu Leu Leu 10 15 20 gac gat ate tcc etc tea att ccg ca ggg gt tcg tgg gcc gta cta 211 Asp Asp He Ser Leu Ser He Pro Gln Gly Ser His Trp Wing Val Leu 25 30 35 ggt cca aat ggc gcc ggt aaa acc acc atg ctg aag ate gca gcc acc 259 Gly Pro Asn Gly Wing Gly Lys Thr Thr Met Leu Lys He Wing Wing Thr 40 45 50 ttg ctg tac cca tcg gaa ggc acc gtg gac ate ctg ggg cat cgc ttt 307 Leu Leu Tyr Pro Ser Glu Gly Thr Val Asp He Leu Gly His Arg Phe 55 60 65 ggt cgg gtg gat act cgt gag ctg cgg aaa here ate ggc ctg gtg gac 355 Gly Arg Val Asp Thr Arg Glu Leu Arg Lys Thr He Gly Leu Val Asp 70 75 80 85 ccg aag caa aga ttt acc aac ctg ccg gcc cae gaa att gtg ctg tcg 403 Pro Lys Gln Arg Phe Thr Asn Leu Pro Wing His Glu He Val Leu Ser 90 95 100 ggg tta acc gcc tcc aac ggg ttg ttg cca cgg tgg tcg gct tcg gct 451 Gly Leu Thr Wing Being Asn Gly Leu Leu Pro Arg Trp Wing Being Wing 105 110 115 tcg gag ttg gag cgg tgc gct ttg atg ttg gag ttg gtg ggc atg here 499 Ser Glu Leu Glu Arg Cys Ala Leu Met Leu Glu Leu Val Gly Met Thr 120 125 130 gcg cgt gcc gat cgt tac tgg gcc gat atg age cag ggc gaa aaa gcc 547 Wing Arg Wing Asp Arg Tyr Trp Wing Asp Met Ser Gln Gly Glu Lys Wing 135 140 145 cgc acc ctg att gct cgt gcg ctg att ate ccg acc cta ctg ctg 595 Arg Thr Leu He Wing Arg Wing Leu He He Being Pro Thr Leu Leu Leu 150 155 160 165 ctt gat gaa ccc acc acc ggc ctt gac ctg ccc gga cgt gaa act ttg 643 Leu Asp Glu Pro Thr Thr Gly Leu Asp Leu Pro Gly Arg Glu Thr Leu 170 175 180 etc agt gtg att gat ggt ttg cga gcc gct ctt ect ggt ctg acg here 691 Leu Ser Val He Asp Gly Leu Arg Wing Wing Leu Pro Gly Leu Thr Thr 185 190 195 gtg atg ate fall falls gtc gaa gag ate gcc gcc tcc acg here gat 739 Val Met He Thr His His Val Glu Glu He Ala Wing Ser Thr Thr Asp 200 205 210 ate etc atg ate aag gac gcc cgc ata ctg gct tcg ggg act gtt tea 787 He Leu Met He Lys Asp Wing Arg He Leu Wing Ser Gly Thr Val Ser 215 220 225 gaa gtg atg act ect gaa aat ttg ggc gcg ctg tat gac atg tcg gtg 835 Glu Val Met Thr Pro Glu Asn Leu Gly Ala Leu Tyr Asp Met Ser Val 230 235 240 245 tcg ttg gaa act gtg cgc age cgg tgg ttc gcg ttc gat gct ctg cat Ser Leu Glu Thr Val Arg Ser Arg Trp Phe Wing Phe Asp Wing Leu His 250 255 260 taaaaggggc tagttttaca ca 906 < 210 > 478 < 211 > 261 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 478 Met Arg Glu Leu Ala Leu Asn Met Ala Gly Val Thr Val Arg Arg Gly 1 5 10 15 Glu Lys Leu Leu Leu Asp Asp He Ser Leu Ser He Pro Gln Gly Ser 20 25 30 His Trp Wing Val Leu Gly Pro Asn Gly Wing Gly Lys Thr Thr Met Leu 35 40 45 Lys He Wing Wing Thr Leu Leu Tyr Pro Ser Glu Gly Thr Val Asp He 50 55 60 Leu Gly His Arg Phe Gly Arg Val Asp Thr Arg Glu Leu Arg Lys Thr 65 70 75 80 He Gly Leu Val Asp Pro Lys Gln Arg Phe Thr Asn Leu Pro Wing His 85 90 95 Glu He Val Leu Ser Gly Leu Thr Ala Ser Asn Gly Leu Pro Arg 100 105 110 Trp Ser Ala Ser Ala Ser Glu Leu Glu Arg Cys Ala Leu Met Leu Glu 115 120 125 Leu Val Gly Met Thr Ala Arg Ala Asp Arg Tyr Trp Ala Asp Met Ser 130 135 140 ? ^^^ ¿^ ^ Gln Gly Glu Lys Ala Arg Thr Leu He Ala Arg Ala Leu He He Ser 145 150 155 160 Pro Thu Leu Leu Leu Asu Glu Pro Thr Thr Gly Leu Asp Leu Pro 165 170 175 Gly Arg Glu Thr Leu Leu Ser Val He Asp Gly Leu Arg Ala Wing Leu 180 185 190 Pro Gly Leu Thr Thr Val Met He Thr His His Val Glu Glu He Wing 195 200 205 Wing Being Thr Thr Asp He Leu Met He Lys Asp Ala Arg He Leu Wing 210 215 220 Ser Gly Thr Val Ser Glu Val Met Thr Pro Glu Asn Leu Gly Ala Leu 225 230 235 240 Tyr Asp Met Ser Val Ser Leu Glu Thr Val Arg Ser Arg Trp Phe Wing 245 250 255 Phe Asp Ala Leu His 260 < 210 > 479 < 211 > 876 < 212 > DNA 10 < 213 > Corynebact, erium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (853) • < 223 > RXA02792 < 400 > 479 aga; acaaagt < gctgcccata ctcatigaact tttgeeg; aacc cccaaccccg < ctggccgtcg 60 atggcct; aga; aaaaatcatc g; actttgtgg aaacccaccc atg ate gag gcc here 115 Met He Glu Ala Thr 1 5 falls cta cgc falls agt 15 ttt ggc gac aac ate gtc ate gat gac gtc acc 163 His Leu Arg His Ser Phe Gly Asp Asn He Val As Asp Asp Val Thr 10 15 20 etc cat cta ect gca falls ggc acc gtc age ttg gtc ggc ccc aac ggc 211 Leu His Leu Pro Wing His Gly Thr Val Ser Leu Val Gly Pro Asn Gly 25 30 35 agt ggc aaa acc acc ctg ctg cgt gca tac ta gga gca ctg ca cca 259 Ser Gly Lys Thr Thr Leu Leu Arg Wing Leu Tyr Gly Wing Leu Gln Pro 40 45 50 aat gaa ggg fall fall fall gta gat ggc gtt cca cta ata age ttg falls 307 • Asn Glu Gly His He His Val Asp Gly Val Pro Leu He Ser Leu His 55 60 65 20 cgc aaa gac ate gca aaa acc atg gcc gta gtc ate caa gaa cat gac 355 Arg Lys Asp He Wing Lys Thr Met Wing Val Val He Gln Glu His Asp 70 75 80 85 tcc gac etc ccc atg acc gtc gct gac ctg gtc tta cta ggc aga etc 403 Ser Asp Leu Pro Met Thr Val Wing Asp Leu Val Leu Leu Gly Arg Leu 90 95 100 ccc falls cag aag atg ttt gcc ggc aac tet ca gct gat cag tta etc 451 Pro His Gln Lys Met Phe Wing Gly Asn Ser Gln Wing Asp Gln Leu Leu 105 110 115 gtt aag gaa gca etc acc cga gtc ggc gcc att falls ctg gcc gac cga 499 Val Lys Glu Wing Leu Thr Arg Val Gly Wing He His Leu Wing Asp Arg 120 125 130 25 ca t tc ggc gca ctt tea ggc ggt gaa cgc cac cgc gtc etc ate gca 547 Gln Phe Gly Ala Leu Ser Gly Gly Glu Arg Gln Arg Val Leu He Wing 135 140 145 cga gca etc gta caa aac gcc here falls att ctg etc gac gaa ccc acc 595 Arg Ala Leu Val Gln Asn Ala Thr His He Leu Leu Asp Glu Pro Thr 150 155 160 165 aac falls etc gac ate cgc tac cag falls gaa gtc ctt falls etc gtc cgc 643 Asn His Leu Asp He Arg Tyr Gln His Glu Val Leu His Leu Val Arg 170 175 180 gaa etc age tea agt tcc ate ate gtc etc falls gac etc aac etc gca 691 Glu Leu Be Ser Be Ser He He Val Leu His Asp Leu Asn Leu Wing 185 190 195 ggt gcc tac age gac falls ate ate etc ctt gac ca gga gtg gtt gtt 739 Gly Ala Tyr Ser Asp His He He Leu Leu Asp Gln Gly Arg Val Val 200 205 210 act caga gga acg ccc tea gag gta ttg acc cca gag cat ttg gaa ect 787 Thr Gln Gly Thr Pro Ser Glu Val Leu Thr Pro Glu His Leu Glu Pro 215 220 225 gtg tat ggc gtt cgt gtt gag cgc ttt gac cta ggc gat gaa gtc cae 835 Val Tyr Gly Val Arg Val Glu Arg Phe Asp Leu Gly Asp Glu Val His 230 235 240 245 ctt cgg ttc aag cgt drops taggagtttt gttgaggagg tgg 876 Leu Arg Phe Lys Arg His 250 < 210 > 480 < 211 > 251 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 480 Met He Glu Ala Thr His Leu Arg His Ser Phe Gly Asp Asn He Val 1 5 10 15 He Asp Asp Val Thr Leu His Leu Pro Wing His Gly Thr Val Ser Leu 20 25 30 Val Gly Pro Asn Gly Ser Gly Lys Thr Thr Leu Leu Arg Ala Leu Tyr 35 40 45 Gly Ala Leu Gln Pro Asn Glu Gly His He His Val Asp Gly Val Pro 50 55 60 Leu He Ser Leu His Arg Lys Asp He Ala Lys Thr Met Ala Val Val 65 70 75 80 He Gln Glu His Asp Being Asp Leu Pro Met Thr Val Wing Asp Leu Val 85 90 95 Leu Leu Gly Arg Leu Pro His Gln Lys Met Phe Wing Gly Asn Ser Gln 100 105 110 Wing Asp Gln Leu Leu Val Lys Glu Wing Leu Thr Arg Val Gly Ala He 115 120 125 His Leu Wing Asp Arg Gln Phe Gly Wing Leu Ser Gly Gly Glu Arg Gln 130 135 140 Arg Val Leu He Wing Arg Wing Leu Val Gln Asn Wing Thr His He Leu 145 150 155 160 Leu Asp Glu Pro Thr Asn His Leu Asp He Arg Tyr Gln His Glu Val 165 170 175 Leu His Leu Val Arg Glu Leu Ser Ser Be Ser He He Val Leu His 180 185 190 Asp Leu Asn Leu Wing Gly Ala Tyr Ser Asp His He He Leu Leu Asp 195 200 205 Gln Gly Arg Val Val Thr Gln Gly Thr Pro Ser Glu Val Leu Thr Pro ^^^^^ ^ ^ ^ ^ ^ ^ ^ ^ 210 215 220 Glu His Leu Glu Pro Val Tyr Gly Val Arg Val Glu Arg Phe Asp Leu 225 230 235 240 Gly Asp Glu Val His Leu Arg Phe Lys Arg His 245 250 < 210 > 481 < 211 > 1161 < 212 > DNA • < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1138) < 223 > RXN02929 < 400 > 481 caggtgggga cctcgcgtat cccagctggt ggaagaaatc gcagcgcagt tgaatcaget 60 tgcttcttct gaagctgtgc cggccgctgc ttaagttttc gtg ctg aag aga att 115 Val Leu Lys Arg He 10 1 5 ttc etc aac ccc tgg gtg gct acc gcg ttg tcg gta gtc att ttg ggg 163 Phe Leu Asn Pro Trp Val Wing Thr Ala Leu Ser Val Val Le Le Gly 10 15 20 ttt gtg gtg ctg ttt tea ggt ttt age ggt gtt att gat tta age ccc 211 Phe Val Val Leu Phe Ser Gly Phe Ser Gly Val He Asp Leu Ser Pro 25 30 35 here gca gtg att aga cat ttg agt ggg cag gac acg etc acc ect cga 259 Thr Ala Val He Arg His Leu Ser Gly Gln Asp Thr Leu Thr Pro Arg 40 45 50 gat cag gcc ate ttc ttt gat ate cgg ctg ect cga att ate gct ggt 307 Asp Gln Ala He Phe Phe Asp He Arg Leu Pro Arg He He Wing Gly 15 55 60 65 gtc att gtc gga gca acg ctg gct att tet ggt gct tet tac cac gcg 355 Val He Val Gly Ala Thr Leu Ala He Ser Gly Ala Ser Tyr Gln Ala 70 75 80 85 gta ttt aga aac ccg ctg gct gat ect tat ttg tg ggt gtg gtc tc gca 403 Val Phe Arg Asn Pro Leu Wing Asp Pro Tyr Leu Le Gly Val Gly Wing 90 95 100 ggt tet ggc ctt ggt gtc acg gg gtg att gtt ggc ggt acc gtg ctg 451 Gly Ser Gly Leu Gly Val Thr Wing Val He Val Gly Gly Thr Val Leu • 105 110 115 gga ttt tet gca ccg age ate ggc gtg att ggt gca gca ttt gta ggt 499 Gly Phe Ser Ala Pro Ser He Gly Val He Gly Ala Wing Phe Val Gly 20 120 125 130 ggt gtt gcc gta gta ctt gcc acg ctg atg gtg agt cgg gga gta gga 547 Gly Val Ala Ala Val Leu Ala Thr Leu Met Val Ser Arg Gly Val Gly 135 140 145 cag gga tea tea acc acc gtg gtt att ttg gcg ggc gtg gcg gtt gt g 595 Gln Gly Be Ser Thr Thr Val Val He Leu Wing Gly Val Wing Val Wing 150 155 160 165 gct ttt gcc agt tcc ate cag acc tat att cag caga cga cae ate gat 643 Wing Phe TO The Being Being He Gln Thr Tyr He Gln Gln Arg His He Asp 170 175 180 acg gcg gcg cgc gta tat gtg tgg atg ttg ggc aac etc aat gtc acc 691 Thr Val Wing Arg Val Tyr Val Trp Met Leu Gly Asn Leu Asn Val Thr 25 185 190 195 ^^ gH & aac tgg atg tcg ate tcc ate gtg gct gtg gtg gcg gga tgc gcg cta 739 Asn Trp Met Ser He Phe He Val Wing Val Val Wing Gly Wing Leu Cys 200 205 210 gcc gtg ate atg tcc tgc gcc agg ttg tta gac gtg atg gct gtt ggt 787 Wing Val He Met Ser Cys Wing Arg Leu Leu Asp Val Met Wing Val Gly 215 220 225 gat gtg gaa gcc cgc here ttg ggc gtc gat cca ggc etc gta cgc att 835 Asp Val Glu Wing Arg Thr Leu Gly Val Asp Pro Gly Leu Val Arg He 230 235 240 245 • ggc att gtc ate gtg gca acc ctt ggt here gct gca gtg gta tcc att Gly He Val He Val Wing Thr Leu Gly Thr Wing Wing Val Val Ser He 250 255 260 tcc ggt etc ate ggg ttt gtg ggc ate att gtt ccg falls gcc ctg cgc 931 Ser Gly Leu He Gly Phe Val Gly He He Val Pro His Ala Leu Arg 265 270 275 cta att gtt ggc ccg ggg cat cgg att tta ctg cca ctg tet ttc gta 979 Leu He Val Gly Pro Gly His Arg He Leu Leu Pro Leu Ser Phe Val 280 285 290 tgg ggt gcc att ttc etc gtg ttg gca gat acc gca ggg cga here ttg 1027 Trp Gly Ala He Phe Leu Val Leu Ala Asp Thr Ala Gly Ar g Thr Leu 295 300 305 10 atg gct ect cag gaa ctt ccc gtg ggt gtg gtg here gct gca etc ggc 1075 Met Wing Pro Gln Glu Leu Pro Val Gly Val Val Thr Wing Ala Leu Gly 310 315 320 325 • gca ccg ttc ttc tta ttt att ttg cgc aga acc age aga caga cga gtt 1123 Wing Pro Phe Phe Leu Phe He Leu Arg Arg Thr Ser Arg Gln Arg Val 330 335 340 cca aaa agg agt gct taagtggcga tcattgaatg cga 1161 Pro Lys Arg Ser Ala 345 < 210 > 482 < 211 > 346 15 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 482 Val Leu Lys Arg He Phe Leu Asn Pro Trp Val Wing Thr Wing Leu Ser 1 5 10 15 Val Val He Leu Gly Phe Val Val Leu Phe Ser Gly Phe Ser Gly Val 20 25 30 He Asp Leu Ser Pro Thr Ala Val He Arg His Leu Ser Gly Gln Asp 35 40 45 Thr Leu Thr Pro Arg Asp Gln Wing He Phe Phe Asp He Arg Leu Pro 20 50 55 60 Arg He He Wing Gly Val He Val Gly Wing Thr Leu Wing He Ser Gly 65 70 75 80 Wing Be Tyr Gln Wing Val Phe Arg Asn Pro Leu Wing Asp Pro Tyr Leu 85 90 95 Leu Gly Val Ser Wing Gly Ser Gly Leu Gly Val Thr Wing Val He Val 100 105 110 Gly Gly Thr Val Leu Gly Phe Ser Wing Pro Ser He Gly Val He Gly 115 120 125 Ala Ala Phe Val Gly Val Val Ala Ala Val Leu Ala Thr Leu Met Val 130 135 140 Ser Arg Gly Val Gly Gln Gly Ser Ser Thr Thr Val Val He Leu Ala 25 145 150 155 160 »- * * - * • * - * • - *" Gly Val Wing Val Wing Wing Phe Wing Being Ser Gln Thr Tyr He Gln 165 170 175 Gln Arg His He Asp Thr Val Wing Arg Val Tyr Val Trp Met Leu Gly 180 185 190 Asn Leu Asn Val Thr Asn Trp Met Be He Phe He Val Wing Val Val 195 200 205 Wing Gly Leu Cys Wing Wing Val Met Met Ser Cys Wing Arg Leu Leu Asp 210 215 220 Val Met Wing Val Gly Asp Val Glu Wing Arg Thr Leu Gly Val Asp Pro 225 230 235 240 Gly Leu Val Arg He Gly He Val He Val Wing Thr Leu Gly Thr Wing 245 250 255 Wing Val Val Ser He Ser Gly Leu He Gly Phe Val Gly He He Val 260 265 270 Pro His Wing Leu Arg Leu He Val Gly Pro Gly His Arg He Leu Leu 275 280 285 Pro Leu Ser Phe Val Trp Gly Wing He Phe Leu Val Leu Wing Asp Thr 290 295 300 Wing Gly Arg Thr Leu Met Wing Pro Gln Glu Leu Pro Val Gly Val Val 305 310 315 320 Thr Ala Ala Leu Gly Ala Pro Phe Phe Leu Phe He Leu Arg Arg Thr 325 330 335 Ser Arg Gln Arg Val Pro Lys Arg Ser Wing 340 345 <210> 483 <211> 1095 < 212 &DNA; &213 &> Corynebacterium gl .utamicum < 220 > < 221 > CDS < 222 > (101) .. (1072) < 223 > FRXA01235 < 400 > 483 ttctgaaigct tgtgccggct zg ctgctitaagt tttcgtgctg aagagaattt 1tcctcaaccc 60 ctgggtggct; accgcgttgt cggtatgtcat tttggggttt gtg gtg ctg ttt tea 115 Val Val Leu Phe Ser 1 5 ggt ttt age ggt gtt att gat tta age ccc here gca gtg att aga cat 163 Gly Phe Ser Gly Val He Asp Leu Ser Pro Thr Ala Val He Arg His 10 15 20 ttg agt ggg cag gac acg etc acc ect cga gat cag gcc ate ttc ttt 211 Leu Ser Gly Gln Asp Thr Leu Thr Pro Arg Asp Gln Wing He Phe Phe 25 30 35 gat ate cgg ctg ect cga att ate gct ggt gtc att gtc gga gca acg 259 Asp He Arg Leu Pro Arg He He Wing Gly Val He Val Gly Wing Thr 40 45 50 ctg gct att tet ggt gct gct tac ca gcg gta ttt aga aac ccg ctg 307 Leu Wing He Ser Gly Wing Wing Tyr Gln Wing Val Phe Arg Asn Pro Leu 55 60 65 gct gat ect tat ttg ttg ggt gtg tcc gca ggt tet ggc ctt ggt gtc 355 Wing Asp Pro Tyr Leu Leu Gly Val Ser Wing Gly Ser Gly Leu Gly Val 70 75 80 85 acg gca gtg att gtt ggc ggt acc gtg ctg gga ttt tet gca ccg age 403 Thr Ala Val He Val Gly Gly Thr Val Leu Gly P I have to be Pro Pro Wing *** «fe¿k.» »* 90 95 100 ate ggc gtg att ggt gca gta ttt gta ggt ggt gtt gcc gca gta ctt 451 He Gly Val He Gly Ala Ala Phe Val Gly Val Val Ala Ala Val Leu 105 110 115 gcc acg ctg atg gtg agt cgg gga gta gga cag gga tea tea acc acc 499 Wing Thr Leu Met Val Ser Arg Gly Val Gly Gln Gly Ser Ser Thr Thr 120 125 130 gtg gtt att ttg gcg ggc gtg gcg gtt gct gct ttt gcc agt tcc ate 547 Val Val He Leu Wing Gly Val Wing Val Wing Wing Phe Wing Ser Ser He 135 140 145 cag acc tat att cag caga cga cae ate gat acg gtg gcg cgc gta tat 595 Gln Thr Tyr He Gln Gln Arg His He Asp Thr Val Wing Arg Val Tyr 150 155 160 165 gtg tgg atg ttg ggc aac etc aat gtc acc aac tgg atg tcg ate ttc 643 Val Trp Met Leu Gly Asn Leu Asn Val Thr Asn Trp Met Ser He Phe 170 175 180 ate gtg gct gtg gtg gcg gga cta tgc gcg gcc gtg ate atg tcc tgc 691 He Val Val Val Val Ala Gly Leu Cys Ala Ala Val He Met Ser Cys 185 190 195 gcc agg ttg tta gac gtg atg gct gtt ggt gat gtg gaa gcc cgc here 739 Wing Arg Leu Leu Asp Val Met Wing Val Gly Asp Val Glu Wing Arg Thr 200 205 210 ttg ggc gtc gat cca ggc etc gta cgc att ggc att gtc ate gtg gca 787 Leu Gly Val Asp Pro Gly Leu Val Arg He Gly He Val He Val Wing 215 220 225 ctt gct gt here gc gtg gta tcc att tcc ggt etc ggg gt ttt 835 Thr Leu Gly Thr Wing Wing Val Val Being Ser Gly Leu He Gly Phe 230 235 240 245 gtg ggc ate att gtt ccg falls gcc ctg cgc cta att gtt ggc ccg ggg 883 Val Gly He He Val Pro His Ala Leu Arg Leu He Val Gly Pro Gly 250 255 260 cat cgg att tta ctg cca ctg tet ttc gta tgg ggt gcc att tcc etc 931 His Arg He Leu Leu Pro Leu Ser Phe Val Trp Gly Wing He Phe Leu 265 270 275 gtg ttg gca gat acc gca ggg cga here ttg atg gct ect cag gaa ctt 979 Val Leu Wing Asp Thr Wing Gly Arg Thr Leu Wing Ala Pro Gln Glu Leu 280 285 290 ccc gtg gg gtg gtg here ggc gcc gcc gcc ccg ttc ttc tta ttt 1027 Pro Val Gly Val Val Thr Ala Ala Leu Gly Ala Pro Phe Phe Leu Phe 295 300 305 att ttg cgc aga acc aga caga cga gtt cca aaa agg agt gct 1072 He Leu Arg Arg Thr Ser Arg Gln Arg Val Pro Lys Arg Ser Wing 310 315 320 taagtggcga t; catt: gaat: g cga 1095 < 210 > 484 < 211 > 324 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 484 Val Val Leu Phe Ser Gly Phe Ser Gly Val He Asp Leu Ser Pro Thr 1 5 10 15 Ala Val He Arg His Leu Ser Gly Gln Asp Thr Leu Thr Pro Arg Asp 20 25 30 Gln Wing He Phe Phe Asp He Arg Leu Pro Arg He He Wing Gly Val 35 40 45 ktk ^ t, ^ 44 He Val Gly Ala Thr Leu Ala He Ser Gly Ala Ala Tyr Gln Ala Val 50 55 60 Phe Arg Asn Pro Leu Ala Asp Pro Tyr Leu Leu Gly Val Ser Ala Gly 65 70 75 80 Be Gly Leu Gly Val Thr Ala Val He Val Gly Gly Thr Val Leu Gly 85 90 95 Phe Ser Ala Pro Be He Gly Val He Gly Ala Ala Phe Val Gly Gly 100 105 110 Val Ala Ala Val Leu Ala Thr Leu Met Val Ser Arg Gly Val Gly Gln 115 120 125 Gly Ser Ser Thr Thr Val Val He Leu Wing Gly Val Wing Val Wing Wing 130 135 140 Phe Wing Being Ser Gln Thr Tyr He Gln Gln Arg His He Asp Thr 145 150 155 160 Val Ala Arg Val Tyr Val Trp Met Leu Gly Asn Leu Asn Val Thr Asn 165 170 175 Trp Met Ser He Phe He Val Wing Val Val Wing Ala Gly Leu Cys Ala Wing 180 185 190 Val He Met Ser Cys Wing Arg Leu Leu Asp Val Met Wing Val Gly Asp 195 200 205 Val Glu Wing Arg Thr Leu Gly Val Asp Pro Gly Leu Val Arg He Gly 210 215 220 He Val He Val Wing Thr Leu Gly Thr Wing Wing Val Val Ser Ser Ser 225 230 235 240 Gly Leu He Gly Phe Val Gly He He Val Pro His Ala Leu Arg Leu 245 250 255 He Val Gly Pro Gly His Arg He Leu Leu Pro Leu Ser Phe Val Trp 260 265 270 Gly Ala He Phe Leu Val Leu Ala Asp Thr Ala Gly Arg Thr Leu Met 275 280 285 Wing Pro Gln Glu Leu Pro Val Gly Val Val Thr Wing Wing Ala Leu Gly Wing 290 295 300 Pro Phe Phe Leu Phe He Leu Arg Arg Thr Ser Arg Gln Arg Val Pro 305 310 315 320 Lys Arg Ser Ala < 210 > 485 < 211 > 1197 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1174) < 223 > RXN02794 < 400 > 485 gcgcccactc atcggcgagc tteaggagat gaggttgatg ctccattgat aatttctttc 60 gctaatagtc aaatgatcat ttgagtgtta gtgttttctc atg ctt ctt tcc gcc 115 Met Leu Leu Ser Wing 1 5 cgc here falls acg agt ttc caa gaa ctt gga etc aat gct agt cgg cgc 163 Arg Thr His Thr Ser Phe Gln Glu Leu Gly Leu Asn Ala Ser Arg Arg 10 15 20 aaa gca ate aac tgg here ctg gca etc act gtg gtg cta att gcc tcc 211 Lys Ala He Asn Trp Thr Leu Ala Leu Thr Val Val Leu He Ala Ser 25 30 35 t i ^? atg ttt gtt ggc gtg etc ate ggt gca tcc ggg acc tea gtg ttt tcc 259 Met Phe Val Gly Val Leu He Gly Wing Ser Gly Thr Ser Val Phe Ser 40 45 50 acg tgg acc gta att age falls cat ctt ttt ggc act gag cta ggt ggc 307 Thr Trp Thr Val He Ser His His Leu Phe Gly Thr Glu Leu Gly Gly 55 60 65 tcc gac act gcc gac gcc ate att tgg tac ate cgc acc cca cgc gtc 355 Be Asp Thr Wing Asp Wing He He Trp Tyr He Arg Thr Pro Arg Val 70 75 80 85 ttg etc gct gcc att gtg ggc gca ggc ctt gcc ctg gca ggt gcc ate 403 Leu Leu Ala Ala He Val Gly Ala Gly Leu Ala Leu Ala Gly Ala He 90 95 100 atg cata gta ctg gtc cga aac atg ctg gca gac ccc tat ate etc ggg 451 Met Gln Val Leu Val Arg Asn Met Leu Wing Asp Pro Tyr He Leu Gly 105 110 115 gtg aac tea ggt gcc agt tgc ggt gcg gcc gct gcc tta ctg ttc gga 499 Val Asn Ser Gly Wing Ser Cys Gly Wing Wing Wing Wing Leu Leu Phe Gly 120 125 130 gtg ggc ggt gga ttt ggc gat tac gcc etc ca ggc age gcg ttt etc 547 Val Gly Ala Gly Phe Gly Asp Tyr Ala Leu Gln Gly Ser Ala Phe Leu 135 140 145 ggc gca atg gca gct tcc gga ttg ate ttc ttc gtg gcg cgc gca gcg 595 Gly Ala Met Ala Ala Ser Gly Leu He Phe Phe Val Wing Arg Ala Wing 150 155 160 165 ggg cgc ate tcc tcg acc cgc ttg ttg atg tcc ggc gta gcg ate gga 643 Gly Arg Be Ser Thr Arg Leu Leu Met Ser Gly Val Wing He Gly 170 175 180 tac atg etc tet gcg gca here age ttt etc ate ttc tcc tcc gac tcc 691 Tyr Met Leu Ser Wing Wing Thr Ser Phe Leu He Phe Ser Ser Asp Ser 185 190 195 gcc gag ggc age cgc tcc gtg ttg ttc tgg ctg ctt gga tcc tta gga 739 Wing Glu Gly Ser Arg Ser Val Leu Phe Trp Leu Leu Gly Ser Leu Gly 200 205 210 ctt gcc gca tgg aat ggg ccg atg gcg ate ate ttc etc ate gtg ggc 787 Leu Ala Ala Trp Asn Gly Pro Met Ala He He Phe Leu He Val Gly 215 220 225 att gcc ctg gcg ttg etc atg gtg ttg ggt ccg caà ttg gat gcc tta 835 He has Ala Leu Ala Leu Leu Met Val Leu Gly Pro Gln Leu Asp Ala Leu 230 235 240 245 aac tcc ggc gat gaa acc gca ctt acc ttg gga gta tcc ect gat cgc 883 Asn Gly Asp Glu Thr Ala Leu Thr Leu Gly Val Ser Pro Asp Arg 250 255 260 etc cgc att etc etc ctg gtg ate acc tgc ctg ctg gtg gga tcc atg 931 Leu Arg He Leu Leu Leu Val He Thr Cys Leu Leu Val Gly Ser Met 265 270 275 gtt gcc atg gcc ggc age ate gga ttc ate ggc ctt gtc ate ccc cae 979 Val Ala Met Ala Gly Ser He Gly Phe He Gly Leu Val He Pro His 280 285 290 ctg gcc agg ctt ttt gtt agt gga aaa falls cga etc atg ctg ect gta 1027 Leu Ala Arg Arg Phe Val Ser Gly Lys His Arg Leu Met Leu Pro Val 295 300 305 tcc gcg ttg atg ggc gca att ttg etc ate tgg gct gat ate gcc gcc 1075 Be Ala Leu Met Gly Ala He Leu Leu He Trp Ala Asp He Ala Ala 310 315 320 325 cgc acc ctg ctt gcg ccc ca g gag att ccc ate ggc ate ate acc gca 1123 Arg Thr Leu Leu Wing Pro Gln Glu He Pro He Gly He He Thr Wing 330 335 340 • kr- iá, 1, etc. ate gga gca ccc ttc etc ctg att ctg gtt cgc cgg cg atg falls acc 1171 Leu He Gly Wing Pro Phe Leu Leu He Leu Val Arg Arg Met His Thr 345 350 355 tac tgatttttaa ggaattatgc gta 1197 Tyr < 210 > 486 < 211 > 358 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 486 Met Leu Leu Be Wing Arg Thr His Thr Ser Phe Gln Glu Leu Gly Leu 1 5 10 15 Asn Wing Being Arg Arg Lys Wing He Asn Trp Thr Leu Wing Leu Thr Val 20 25 30 Val Leu He Wing Being Met Phe Val Gly Val Leu He Gly Wing Ser Gly 35 40 45 Thr Ser Val Phe Ser Thr Trp Thr Val He Ser His His Leu Phe Gly 50 55 60 10 Thr Glu Leu Gly Gly Ser Asp Thr Wing Asp Wing He He Trp Tyr He 65 70 75 80 • Arg Thr Pro Arg Val Leu Leu Wing Wing Val Gly Wing Gly Leu Wing 85 90 95 Leu Wing Gly Wing He Met Gln Val Leu Val Arg Asn Met Leu Wing Asp 100 105 110 Pro Tyr He Leu Gly Val Asn Ser Gly Wing Ser Cys Gly Ala Ala Ala 115 120 125 Ala Leu Leu Phe Gly Val Gly Ala Gly Phe Gly Asp Tyr Ala Leu Gln 130 135 140 Gly Ser Ala Phe Leu Gly Ala Ala Ala Ala Ser Gly Leu He Phe Phe 15 145 150 155 160 Val Ala Arg Ala Ala Gly Arg Be Ser Thr Arg Leu Leu Met Ser 165 170 175 Gly Val Ala He Gly Tyr Met Leu Ser Ala Ala Thr Ser Phe Leu He 180 185 190 Phe Ser Ser Asp Be Wing Glu Gly Ser Arg Ser Val Leu Phe Trp Leu 195 200 205 Leu Gly Be Leu Gly Leu Wing Wing Trp Asn Gly Pro Met Wing He He • 210 215 220 Phe Leu He Val Gly He Ala Leu Wing Leu Leu Met Val Leu Gly Pro 225 230 235 240 Gln Leu Asp Wing Leu Asn Ser Gly Asp Glu Thr Wing Leu Thr Leu Gly 20 245 250 255 Val Ser Pro Asp Arg Leu Arg He Leu Leu Leu Val He Thr Cys Leu 260 265 270 Leu Val Gly Ser Met Val Wing Ala Wing Gly Ser He Gly Phe He Gly 275 280 285 Leu Val He Pro His Leu Wing Arg Arg Phe Val Ser Gly Lys His Arg 290 295 300 Leu Met Leu Pro Val Ser Wing Leu Met Gly Wing He Leu Leu He Trp 305 310 315 320 Wing Asp He Wing Wing Arg Thr Leu Leu Wing Pro Gln Glu He Pro He 325 330 335 Gly He He Thr Wing Leu He Gly Wing Pro Phe Leu Leu He Leu Val 25 340 345 350 Arg Arg Met His Thr Tyr 355 <; 210 > 487 < 211 > 364 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > • < 221 > CDS < 222 > (101) .. (364) < 223 > FRXA01419 < 400 > 487 gcgcccactc atcggcgagc tteaggagat gatggtttgatg ctccattgat; aatttctttc 60 gctaatatgtc; aaatgatcat ttgagtgtta gtgttttctc atg ctt ctt tcc gcc 115 Met Leu Leu Ser Wing 1 5 cgc here falls acg agt ttc caa gaa ctt gga etc aat gct agt cgg cgc 163Arg Thr His Thr Ser Phe Gln Glu Leu Gly Leu Asn Wing Ser Arg Arg 10 10 15 20 aaa gca ate aac tgg here ctg gca etc act gtg gtg cta att gcc tcc 211 Lys Ala He Asn Trp Thr Leu Ala Leu Thr Val Val Leu He Ala Ala Ser 25 30 35 • atg ttt gtt ggc gtg etc ate ggt gca tcc ggg acc tea gtg ttt tcc 259 Met Phe Val Gly Val Leu He Gly Wing Ser Gly Thr Ser Val Phe Ser 40 45 50 acg tgg acc gta att age falls cat ctt ttt ggc act gag cta ggt ggc 307 Thr Trp Thr Val He Ser His His Leu Phe Gly Thr Glu Leu Gly Gly 55 60 65 tcc gac act gcc gac gcc ate att tgg tac tc cc cc cc acc accc cc gc 355 Ser Asp Thr Ala Asp Wing He He Trp Tyr He Arg Thr Pro Arg Val 15 70 75 80 85 ttg etc gct 364 Leu Leu Ala < 210 > 488 < 211 > 8E ¡< 212 > PRT < 213 > Corynebact: erium glutamicum • < 400 > 488 Met Leu Leu Be Wing Arg Thr His Thr Ser Phe Gln Glu Leu Gly Leu 20 1 5 10 15 Asn Wing Being Arg Arg Lys Wing He Asn Trp Thr Leu Wing Leu Thr Val 20 25 30 Val Leu He Wing Being Met Phe Val Gly Val Leu He Gly Wing Ser Gly 35 40 45 Thr Ser Val Phe Ser Thr Trp Thr Val He Ser His His Leu Phe Gly 50 55 60 Thr Glu Leu Gly Gly Ser Asp Thr Wing Asp Wing He He Trp Tyr He 65 70 75 80 Arg Thr Pro Arg Val Leu Leu Wing 85 25 < 210 > 489 * ~ * .. i.? «.. < 211 > 744 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (721) < 223 > FRXA02794 • < 400 > 489 tgaactcagg tgccagttgc ggtgcggccg ctgccttact gttcggagtg ggcgctggat 60 ttggcgatta cgccctccaa gcagcgcgtt tctcggcgca atg gca gct tcc gga 115 Met Wing Wing Gly 1 5 ttg ate ttc ttc gtg gcg cgc gca gcg ggg cgc ate tcc tcg acc cgc 163 Leu He Phe Phe Val Ala Arg Ala Wing Gly Arg He Ser Ser Thr Arg 10 15 20 ttg ttg atg tcc ggc gta gcg ate gga tac atg etc tet gcg gca here 211 Leu Leu Met Ser Gly Val Wing He Gly Tyr Met Leu Ser Wing Ala Thr 25 30 35 10 age ttt etc ate ttc tcc tcc gac tcc gcc gaa ggc age cgc tcc gtg 259 Ser Phe Leu He Phe Ser Ser Asp Be Wing Glu Gly Ser Arg Ser Val 40 45 50 ttg ttc tgg tt ctg tt gga ct tta gga ct ggg gt tgg aat ggg ccg 307 Leu Phe Trp Leu Leu Gly Ser Leu Gly Leu Wing Wing Trp Asn Gly Pro 55 60 65 atg gcg ate ate ttc etc ate gtg ggc att gcc ctg gcg ttg etc atg 355 Met Wing He He Phe Leu He Val Gly He Ala Leu Wing Leu Leu Met 70 75 80 85 gtg ttg ggt ccg caà ttg gat gcc tta aac tcc ggc gat gaa acc gca 403 Val Leu Gly Pro Gln Leu Asp Ala Leu Asn Ser Gly Asp Glu Thr Wing 90 95 100 15 ctt acc ttg gga gta tcc ect gat cgc etc cgc att etc etc ctg gtg 451 Leu Thr Leu Gly Val Ser Pro Asp Arg Leu Arg Leu Leu Leu Leu Val 105 110 115 ate acc tgc ctg ctg gtg gga tcc atg gtt gcc gcc atg gcc ggc age ate 499 He Thr Cys Leu Leu Val Gly Ser Met Val Wing Ala Wing Gly Ser He 120 125 130 gga ttc ate ggc ctt gtc ate ccc falls ctg gcc agg cgt ttt gtt agt 547 Gly Phe ile Gly Leu Val He Pro His Leu Wing Arg Arg Phe Val Ser 135 140 145 • gga aaa falls cga etc atg ctg ect gta tc gcg ttg atg ggc gca att 595 Gly Lys His Arg Leu Met Leu Pro Val Ser Ala Leu Met Gly Ala He 150 155 160 165 20 ttg etc ate tgg gct gat ate gcc gcc cgc acc ctg ctt gcg ccc ca c 643 Leu Leu He Trp Wing Asp He Wing Wing Arg Thr Leu Leu Wing Pro Gln 170 175 180 gag att ccc ate ggc ate ate acc gca etc ate gga gca ccc ttc etc 691 Glu He Pro He Gly He He Thr Wing Leu He Gly Wing Pro Phe Leu 185 190 195 ctg att ctg gtt cgc cgg atg falls acc tac tgatttttaa ggaattatgc 741 Leu He Leu Val Arg Arg Met His Thr Tyr 200 205 gta 744 < 210 > 490 25 < 211 > 207 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 490 Met Wing Wing Being Gly Leu He Phe Phe Val Wing Arg Wing Wing Gly Arg 1 5 10 15 He Being Ser Thr Arg Leu Leu Met Ser Gly Val Wing He Gly Tyr Met 20 25 30 Leu Ser Wing Wing Thr Ser Phe Leu He Phe Being Ser Asp Being Wing Glu • 35 40 45 Gly Being Arg Being Val Leu Phe Trp Leu Leu Gly Being Leu Gly Leu Wing 50 55 60 Wing Trp Asn Gly Pro Met Wing He He Phe Leu He Val Gly He Wing 65 70 75 80 Leu Ala Leu Leu Met Val Leu Gly Pro Gln Leu Asp Ala Leu Asn Ser 85 90 95 Gly Asp Glu Thr Wing Leu Thr Leu Gly Val Ser Pro Asp Arg Leu Arg 100 105 110 He Leu Leu Leu Val He Thr Cys Leu Leu Val Gly Ser Met Val Wing 115 120 125 10 Met Wing Gly Ser He Gly Phe He Gly Leu Val He Pro His Leu Wing 130 135 140 Arg Arg Phe Val Ser Gly Lys His Arg Leu Met Leu Pro Val Wing 145 150 155 160 • Leu Met Gly Wing He Leu Leu He Trp Wing Asp He Wing Wing Arg Thr 165 170 175 Leu Leu Ala Pro Gln Glu He Pro He Gly He He Thr Ala Leu He 180 185 190 Gly Ala Pro Phe Leu Leu He Leu Val Arg Arg Met His Thr Tyr 195 200 205 <; 210 > 491 15 < 211 > 1140 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1117) < 223 > RXN03079 • < 400 > 491 gageggggtt gctatcggcc gaaagtttag ggttttgttc aatetgttgg ttagtattgc 60 ttgggtaaac aagtcataac aattttcatt aagggtcgtt ttg tcg cgc here ggt 115 20 Leu Ser Arg Thr Gly 1 5 gtt tcg aaa aaa cca aag etc acc gct ect gtt gtc ate ate ggc acc 163 Val Ser Lys Lys Pro Lys Leu Thr Wing Pro Val Val He He Gly Thr 10 15 20 etc gtc ttg ttg ate ate gcc ttc acc gct tcc etc atg ctg ggt ccc 211 Leu Val Leu Leu He He Wing Phe Thr Wing Being Leu Met Leu Gly Pro 25 30 35 gtg acg gtt cca ttg aat gag ctt gca acc aac ccc gtt gtc acc gat 259 Val Thr Val Pro Leu Asn Glu Leu Wing Thr Asn Pro Val Val Thr Asp 40 45 50 ate cgt gca cca cgc att ate ate gca gca ttg gtg ggt gcg gcg ctg 307 25 He Arg Wing Pro Arg He He Wing Wing Wing Leu Val Gly Wing Wing Leu 55 60 65 gct gtc tcc ggt gcg ate atg cag acg gtg ttt falls aac ccg ttg gcg 355 Wing Val Ser Gly Wing He Met Gln Thr Val Phe His Asn Pro Leu Wing 70 75 80 85 gat ccc ggc att gtg ggt gtg tcc tcc ggt gca gct gtt gca gct gtc 403 Asp Pro Gly He Val Gly Val Ser Ser Gly Wing Wing Val Wing Wing Val 90 95 100 ttg gcg att gtc acc ggt gcg agt ttc ttt ggc cag tgg acc gtt ect 451 Leu Ala He Val Thr Gly Ala Ser Phe Phe Gly Gln Trp Thr Val Pro 105 110 115 ttt gcg gcc ttc gtg ggc gca ttg gtc acg gtg gct gtg tat tat ttg 499 Phe Ala Ala Phe Val Gly Ala Leu Val Thr Val Ala Val Val Tyr Leu 120 125 130 ate gct agt tcc cgc gcg atg gat ggc cgt ggc gca gat ccg gcc acg 547 Wing Wing Being Arg Wing Met Asp Gly Arg Gly Wing Asp Pro Wing Thr 135 140 145 ttg gta ctg gtc ggc atg gct ate act gcc ttt tg ggt gct gtt att 595 Leu Val Leu Val Gly Met Wing He Thr Wing Phe Leu Gly Wing Val He 150 155 160 165 tcc age gcc act gcg aac gca cca ca a gat tet gag ctt cga tcc gtg 643 10 Be Being Wing Thr Wing Asn Wing Pro Gln Asp Being Glu Leu Arg Being Val 170 175 180 acg ttt tgg etc aac ggc gat ctg gta tet cgg acg tgg gaa cat gtg 691 • Thr Phe Trp Leu Asn Gly Asp Leu Val Ser Arg Thr Trp Glu His Val 185 190 195 ggc gtt gc ata ata ccc att ate gtt ggg ttg att cta gct ate ggc 739 Gly Val Ala He He Pro Pro He He Val Gly Leu He Leu Wing He Gly 200 205 210 ggt tcc cgc gat ctg aac ttg ttg ctg ctg ggt gat tcc here gcg ca 787 Gly Ser Arg Asp Leu Asn Leu Leu Leu Gly Asp Ser Thr Ala Gln 215 220 225 here tet gga etc aac gtc aac cgc gca cgc ate att ttg cta gca ctt 835 15 Thr Ser Gly Leu Asn Val Asn Arg Wing Arg He He Leu Leu Wing Leu 230 235 240 245 gcg gca ctg etc acc gcc here gct gtt gcg gtc tcc ggc acc att acg 883 Ala Ala Leu Leu Thr Ala Thr Ala Val Ala Val Ser Gly Thr He Thr 250 255 260 ttt gtt gt gt ttg gta ccc ctg gtg gtg cgc att gtt tta ggt gcc 931 Phe Val Gly Leu Val Val Pro His Leu Val Arg He Val Leu Gly Ala 265 270 275 gat falls cga gcg tta etc ccg gcc gcc gcg att ttg ggc gcc acg ttt 979 • Asp His Arg Ala Leu Leu Pro Ala Ala Ala He Leu Gly Ala Thr Phe 280 285 290 gtt ate gtt tcc gac act gtt gcc cgc atg ate ttc tcc ccc aattee ggttcc 1027 20 Val He Val Ser Asp Thr Val Ala Arg Met He Phe Ser Pro He Val 295 300 305 ttg caa here ggc gtg gtg gtg gcg ttc att ggc tea cca att ttttcc cctttt 1075 Leu Gln Thr Gly Val Val Val Ala Phe He Gly Ser Pro He Phe Leu 310 315 320 325 tat tta ctg etc age atg cgc aag cga cgc gga ttg ggg ctg 1117 Tyr Leu Leu Leu Ser Met Arg Lys Arg Arg Gly Leu Gly Leu 330 335 taaaaactca tgeetcaatt agt 1140 < 210 > 492 < 211 > 339 25 < 212 > PRT . , .t.i.A < 213 > Corynebacterium glutamicum < 400 > 492 Leu Ser Arg Thr Gly Val Ser Lys Lys Pro Lys Leu Thr Wing Pro Val 1 5 10 15 Val He He Gly Thr Leu Val Leu Leu He He Wing Phe Thr Wing Ser 20 25 30 Leu Met Leu Gly Pro Val Thr Val Pro Leu Asn Glu Leu Ala Thr Asn 35 40 45 • Pro Val Val Thr Asp He Arg Ala Pro Arg He He He Ala Ala Leu 50 55 60 Val Gly Ala Ala Leu Ala Val Ser Gly Ala He Met Gln Thr Val Phe 65 70 75 80 His Asn Pro Leu Wing Asp Pro Gly He Val Val Val Ser Ser Gly Wing 85 90 95 Wing Val Wing Wing Val Leu Wing Hew Val Thr Gly Wing Being Phe Phe Gly 100 105 110 Gln Trp Thr Val Pro Phe Wing Wing Phe Val Gly Wing Leu Val Thr Val 115 120 125 Wing Val Val Tyr Leu He Wing Ser Ser Arg Wing Met Asp Gly Arg Gly 10 130 135 140 Wing Asp Pro Wing Thr Leu Val Leu Val Gly Met Wing He Thr Wing Phe 145 150 155 160 Leu Gly Wing Val He Ser Ser Wing Thr Wing Asn Wing Pro Gln Asp Ser 165 170 175 Glu Leu Arg Ser Val Thr Phe Trp Leu Asn Gly Asp Leu Val Ser Arg 180 185 190 Thr Trp Glu His Val Gly Val Wing He He Pro He He Val Val Gly Leu 195 200 205 He Leu Wing He Gly Gly Ser Arg Asp Leu Asn Leu Leu Leu Gly 210 215 220 Asp Ser Thr Ala Gln Thr Ser Gly Leu Asn Val Asn Arg Ala Arg He 15 225 230 235 240 He Leu Leu Ala Leu Ala Ala Leu Leu Thr Ala Thr Ala Val Ala Val 245 250 255 Ser Gly Thr He Thr Phe Val Gly Leu Val Val Pro His Leu Val Arg 260 265 270 He Val Leu Gly Ala Asp His Arg Ala Leu Leu Pro Ala Ala Ala He 275 280 285 Leu Gly Wing Thr Phe Val He Val Being Asp Thr Val Wing Arg Met He 290 295 300 • Phe Ser Pro He Val Leu Gln Thr Gly Val Val Val Wing Phe He Gly 305 310 315 320 Ser Pro He Phe Leu Tyr Leu Leu Leu Ser Met Arg Lys Arg Arg Gly 20 325 330 335 Leu Gly Leu < 210 > 493 < 211 > 1140 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1117) < 223 > FRXA02865 25 < 400 > 493 gag, cggggtt gctatcgg, cc gaaagtttag ggtttt, gtte aatetgttgg ttagtattgc: 60 ttgggtaaac aagtcataac aattttcatt aa, gggtcgtt ttg tcg cgc here ggt 115 Leu Ser Arg Thr Gly 1 5 gtt tcg aaa aaa cca aag etc acc gct ect gtt gtc ate ate ggc acc 163 Val Ser Lys Lys Pro Lys Leu Thr Wing Pro Val Val He He Gly Thr 10 15 20 etc gtc ttg ttg ate ate gcc ttc acc gct tcc etc atg ctg ggt ccc 211 Leu Val Leu Leu He He Wing Phe Thr Wing Being Leu Met Leu Gly Pro 25 30 35 gtg acg gtt cca ttg aat gag ctt gca acc aac ccc gtt gtc acc gat 259 Val Thr Val Pro Leu Asn Glu Leu Wing Thr Asn Pro Val Val Thr Asp 40 45 50 ate cgt gca cca cgc att ate ate gca gca ttg gtg ggt gcg gcg ctg 307 He Arg Wing Pro Arg He He Wing Wing Wing Leu Val Gly Wing Wing Leu 55 60 65 gct gtc tcc ggt gcg ate atg cag acg gtg ttt falls aac ccg ttg gcg 355 Ala Val Ser Gly Ala He Met Gln Thr Val Phe His Asn Pro Leu Ala 70 75 80 85 gat ccc ggc att gtg ggt gtg tcc tcc ggt gca gct gtt gca gct gtc 403 Asp Pro Gly He Val Gly Val Ser Ser Gly Wing Wing Val Wing Wing Val 90 95 100 ttg gcg att gtc acc ggt gcg agt ttc ttt ggc cag tgg acc gtt ect 451 Leu Ala He Val Thr Gly Ala Ser Phe Phe Gly Gln Trp Thr Val Pro 105 110 115 ttt gcg gcc ttc gtg ggc gca ttg gtc acg gtg gct gtg tat tat ttg 499 Phe Ala Ala Phe Val Gly Ala Leu Val Thr Val Ala Val Val Tyr Leu 120 125 130 ate gct agt tcc cgc gcg atg gat ggc cgt ggc gca gat ccg gcc acg 547 He Wing Being Ser Arg Wing Met Asp Gly Arg Gly Wing Asp Pro Wing Thr 135 140 145 ttg gta ctg gtc ggc atg gct ate act gcc ttt tgg ggt gct gtt att 595 Leu Val Leu Val Gly Met Ala He Thr Ala Phe Leu Gly Ala Val He 150 155 160 165 tcc age gcc act gcg aac gca cca ca a gat tet gag ctt cga tcc gtg 643 Be Being Wing Thr Wing Asn Wing Pro Gln Asp Being Glu Leu Arg Being Val 170 175 180 acg ttt tgg etc aac ggc gat ctg gta tet cgg acg tgg gaa cat gtg 691 Thr Phe Trp Leu Asn Gly Asp Leu Val Ser Arg Thr Trp Glu His Val 185 190 195 ggc gtt gc ata ata ccc att ate gtt ggg ttg att cta gct ate ggc 739 Gly Val Ala He He Pro Pro He He Val Gly Leu He Leu Ala He Gly 200 205 210 ggt tcc cgc gat ctg aac ttg ttg ctg ctg ggt gat tcc here gcg ca 787 Gly Ser Arg Asp Leu Asn Leu Leu Leu Leu Gly Asp Ser Thr Ala Gln 215 220 225 here tet gga etc aac gtc aac cgc gca cgc ate att ttg cta gca ctt 835 Thr Ser Gly Leu Asn Val Asn Arg Wing Arg He He Leu Leu Wing Leu 230 235 240 245 gcg gca ctg etc acc gcc here gct gtt gcg gtc tcc ggc acc att acg 883 Ala Ala Leu Leu Thr Ala Thr Ala Val Ala Ala Ser Gly Thr He Thr 250 255 260 ttt gtt gt gt t gt gta ccc ctg gtg cgc att gtt tta ggt gcc gcc 931 Phe Val Gly Leu Val Val Pro His Leu Val Arg He Val Leu Gly Wing 265 270 275 gat falls cga gcg tta etc ccg gcc gcc gcg att ttg ggc gcc acg ttt 979 Asp His Arg Ala Leu Leu Pro Ala Ala Ala He Leu Gly Ala Thr Phe 280 285 290 gtt ate gtt tcc gac act gtt gcc cgc atg ate ttc tcc ccc ate gtc 1027 Val He Val Ser Asp Thr Val Ala Arg Met He Phe Ser Pro He Val 295 300 305 ttg caá here ggc gtg gtg gtg gcg ttc att ggc tea cca att ttc ctt 1075 Leu Gln Thr Gly Val Val Val Wing Phe He Gly Ser Pro He Phe Leu 310 315 320 325 tat tta ctg etc age atg cgc aag cga cgc gga ttg ggg ctg 1117 • Tyr Leu Leu Leu Ser Met Arg Lys Arg Arg Gly Leu Gly Leu 330 335 taaaaactca tgeetcaatt agt 1140 < 210 > 494 < 211 > 339 < 212 > PRT < 213 >; Corynebacterium glutamicum < 400 > 494 Leu Ser Arg Thr Gly Val Ser Lys Lys Pro Lys Leu Thr Wing Pro Val 10 1 5 10 15 Val He He Gly Thr Leu Val Leu Leu He He Wing Phe Thr Wing Ser 20 25 30 Leu Met Leu Gly Pro Val Thr Val Pro Leu Asn Glu Leu Wing Thr Asn 35 40 45 Pro Val Val Thr Asp He Arg Wing Pro Arg He He Wing Wing Wing Leu 50 55 60 Val Gly Wing Wing Wing Wing Val Wing Gly Wing He Met Gln Thr Val Phe 65 70 75 80 His Asn Pro Leu Wing Asp Pro Gly He Val Val Val Ser Ser Gly Wing 85 90 95 Wing Val Wing Wing Val Leu Wing Hew Val Thr Gly Wing Ser Phe Phe Gly 15 100 105 110 Gln Trp Thr Val Pro Phe Wing Wing Phe Val Gly Wing Leu Val Thr Val 115 120 125 Wing Val Val Tyr Leu He Wing Ser Ser Arg Wing Met Asp Gly Arg Gly 130 135 140 Wing Asp Pro Wing Thr Leu Val Leu Val Gly Met Wing He Thr Wing Phe 145 150 155 160 Leu Gly Wing Val Be Ser Wing Thr Wing Asn Wing Pro Gln Asp Ser 165 170 175 • Glu Leu Arg Ser Val Thr Phe Trp Leu Asn Gly Asp Leu Val Ser Arg 180 185 190 Thr Trp Glu His Val Gly Val Wing He He Pro He He Val Gly Leu 20 195 200 2 05 He Leu Wing He Gly Gly Being Arg Asp Leu Asn Leu Leu Leu Leu Gly 210 215 220 Asp Being Thr Wing Gln Thr Ser Gly Leu Asn Val Asn Arg Wing Arg He 225 230 235 240 He Leu Leu Ala Leu Ala Wing Leu Leu Thr Ala Thr Ala Val Ala Ala 245 250 255 Ser Gly Thr He Thr Phe Val Gly Leu Val Val Pro His Leu Val Arg 260 265 270 He Val Leu Gly Ala Asp His Arg Ala Leu Leu Pro Ala Ala Ala He 275 280 285 Leu Gly Ala Thr Phe Val Val Val Ser Asp Thr Val Ala Arg Met He 25 290 295 300 S & A X Phe Ser Pro He Val Leu Gln Thr Gly Val Val Val Wing Phe He Gly 305 310 315 320 Ser Pro He Phe Leu Tyr Leu Leu Leu Ser Met Arg Lys Arg Arg Gly 325 330 335 Leu Gly Leu < 210 > 495 < 211 > 1695 < 212 > DNA • < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1672) < 223 > RXA00181 < 400 > 495 gtatatteag, acacccacgt c < gatt; agtgt tgtagttcac agtgettatt 1ttttatttgt 60 atctttgcac < gtttgtcccc tacccaaaag gagaaacetc atg age gat acac 115 Met Ser Asp Asn Thr 10 1 5 tgg ttc ate ata gcc ate gtt ate tat atg ttg gtg atg gtg etc tie 163 Trp Phe He He Wing He Val Tyr Met Leu Val Met Val Leu He 10 15 20 • ggc tat tgg agt tac cgc aag here gaa aaa tac gac gac tac atg etc 211 Gly Tyr Trp Ser Tyr Arg Lys Thr Glu Lys Tyr Asp Asp Tyr Met Leu 25 30 35 gcc ggc cgc ggg etc aac ect ttt gtt gcc gca atg tcc gca ggt gcc 259 Wing Gly Arg Gly Leu Asn Pro Phe Val Wing Wing Met Being Wing Gly Wing 40 45 50 tea gat atg tea ggt tgg ctg etc atg ggt ctg ccc ggc gcg ctg ttt 307 Being Asp Met Ser Gly Trp Leu Leu Met Gly Leu Pro Gly Ala Leu Phe 15 55 60 65 gtc acc ggc atg tcc gag ttg tgg ggg gtc gga gtc etc acc att ggt 355 Val Thr Gly Met Ser Glu Leu Trp He Wing Val Gly Leu Thr He Gly 70 75 80 85 gca tgg gcg aac tgg atg tgg gtg gca ect cgt ctt ct tet tat tcc 403 Wing Trp Wing Asn Trp Met Trp Val Wing Pro Arg Leu Arg Ser Tyr Ser 90 95 100 gaa ate tcg gcc aac tea ate acc ctct ect tea ttc ttt gag aac cga 451 Glu He Ser Wing Asn Ser He Thr Leu Pro Ser Phe Phe Glu Asn Arg • 105 110 115 ctt cgc gat aaa tet cgc gcg ctt cgc ate att gca gca cta att ate 499 Leu Arg Asp Lys Ser Arg Ala Leu Arg He He Ala Ala Leu He He 20 120 125 130 att gtg ttc ttc acc ttc tac att tet tea ggc atg gtt ggt ggt gga 547 He Val Phe Phe Thr Phe Tyr He Ser Ser Gly Met Val Wing Gly Gly 135 140 145 gtg tat tgg gag tcc acg ttt ggt gga gat tat tat cta etc ggt atg gcc 595 Val Tyr Trp Glu Be Thr Phe Gly Gly Asp Tyr Leu Leu Gly Met Wing 150 155 160 165 att gtc gca ggt gtg here gtg ctg tat acc ttc att gga gga ttc ctt 643 He Val Wing Gly Val Thr Val Leu Tyr Thr Phe He Gly Gly Phe Leu 170 175 180 gct gtg tet tat here gac gca gtt cag ggg act ate atg ttc ttc tcg 691 Wing Val Ser Tyr Thr Asp Ala Val Gln Gly Thr He Met Phe Phe Ser 25 185 190 195 l rL. Í, ______ ii ttg ate ate gtg cca gtc atg gca tat ttc gca ctg gcg aac ccc atg 739 Leu He He Val Pro Val Met Ala Tyr Phe Ala Leu Ala Asn Pro Met 200 205 210 gat att tgg age tac ggc ccg drops acc gat 787 Asp He Trp Ser Phe Wing Asn Ser Asn Asp Tyr Gly Pro His Thr Asp 215 220 225 gga att ggc aat ccc acc tac ttc tcc atg ate agt ggc att tet gca 835 Gly He Gly Asn Pro Thr Tyr Phe Ser Met He Ser Gly He Ser Wing 230 235 240 245 • gca gca ate att ggt aac tta ggt tgg ggt ctt gga tac tcc ggc cag 883 Ala Ala He He Gly Asn Leu Gly Trp Gly Leu Gly Tyr Phe Gly Gln 250 255 260 cca falls att gtg gtt cgt ttc atg gca ctt cgc here cca gct gaa gca 931 Pro His He Val Val Arg Phe Met Ala Leu Arg Thr Pro Ala Glu Ala 265 270 275 aag cag ggt cgt cgc ate ggt att tcc tgg atg ata ate tgc ctg att 979 Lys Gln Gly Arg Arg He Gly He Ser Trp Met He He Cys Leu He 280 285 290 ggt gca acc ttt acc gca att ate tcc here gtt ttc ttt gca ca aac 1027 Gly Ala Thr Phe Thr Ala He He Ser Ser Thr Val Phe Phe Ala Gln Asn 10 295 300 305 ccc gac gcc aac ate act gac here agg gct tat gag tcc ate ttc cta 1075 Pro Asp Wing Asn He Thr Asp Thr Arg Wing Tyr Glu Ser He Phe Leu 310 315 320 325 • gat ctt gcc cgg atg ctg ttc falls cca ttg ate gct gga ctt att ctg 1123 Asp Leu Wing Arg Met Leu Phe His Pro Leu He Wing Gly Leu He Leu 330 335 340 act gct gtt etc gcg gcc ate atg tet acc atg tcg tea cag ctg ctg 1171 Thr Ala Val Leu Wing Ala Met Met Ser Thr Met Being Ser Gln Leu Leu 345 350 355 gtc acc gca tet tcc ctg att gag gac ctg ctg aag gta gtt aaa aag 1219 Val Thr Wing Being Ser Leu He Glu Asp Leu Leu Lys Val Val Lys Lys 15 360 365 370 gac tcg ctg age gaa cgc acc ctg ate atg ctg tet cgt gcc gtc 1267 Asp Ser Leu Ser Glu Arg Thr Leu He Met Leu Ser Arg Wing Thr Val 375 380 385 ate att ctg gcg ate att gca gca gcc atg gct att aac ccg tet gat 1315 He He Leu Wing He He Wing Wing Wing Met Wing He Asn Pro Ser Asp 390 395 400 405 tcc tcc etc gga ttg gtg gtg ttt gcg tgc gca gga ttc ggc tet gca 1363 Be He Leu Gly Leu Val Gly Phe Wing Trp Wing Gly Phe Gly Be Wing • 410 415 420 ttt ggt ccg ate ata ctt gct age ctt tat tgg aag cgt etc aac gcc 1411 Phe Gly Pro He He Leu Wing Being Leu Tyr Trp Lys Arg Leu Asn Wing 20 425 430 435 gcc ggc gct ate tcc ggc atg att act ggt gct att gtc tcc ate gcg 1459 Ala Gly Ala He Ser Gly Met He Thr Gly Ala He Val Ser He Ala 440 445 450 tgg ggt atg tcc cca cta age gat acg ttg tat gaa ate ate cca ggt 1507 Trp Gly Met Pro Pro Leu Ser Asp Thr Leu Tyr Glu He He Pro Gly 455 460 465 ttc gcc ttg gca acc ate gtg atg gtc gtt gtt tcc etc ctg here aag 1555 Phe Ala Leu Ala Thr He Val Val Val Val Val Leu Ser Leu Thr Lys 470 475 480 485 gaa ccc tcc gaa gaa ate etc aac gag ttt gaa acc gcc aag gat ctt 1603 Glu Pro Ser Glu Glu He Leu Asn Glu Phe Glu Thr Wing Lys Asp Leu 25 490 495 500 gct gcc gtg gaa tea aac gag gat gtt gat ttc gct gc gac gc gct 1651 Ala Ala Ala Val Glu Ser Asn Glu Asp Val Asp Phe Ala Asp Ala Ala 505 510 515 cag aag ctt tcg aaa gaa agt taagccttag agggaaccaa acg 1695 Gln Lys Leu Ser Lys Glu Ser 520 < 210 > 496 < 211 > 524 • < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 496 Met Ser Asp Asn Thr Trp Phe He He Wing He Val He Tyr Met Leu 1 5 10 15 Val Met Val Leu He Gly Tyr Trp Ser Tyr Arg Lys Thr Glu Lys Tyr 20 25 30 Asp Asp Tyr Met Leu Wing Gly Arg Gly Leu Asn Pro Phe Val Wing Wing 35 40 45 Met Ser Wing Gly Wing Ser Asp Met Ser Gly Trp Leu Leu Met Gly Leu 50 55 60 10 Pro Gly Wing Leu Phe Val Thr Gly Met Ser Glu Leu Trp He Wing Val 65 70 75 80 Gly Leu Thr He Gly Wing Trp Wing Asn Trp Met Trp Val Wing Pro Arg • 85 90 95 Leu Arg Ser Tyr Ser Glu He Ser Wing Asn Ser He Thr Leu Pro Ser 100 105 110 Phe Phe Glu Asn Arg Leu Arg Asp Lys Ser Arg Ala Leu Arg He He 115 120 125 Ala Ala Leu He He He Val Phe Phe Thr Phe Tyr He Ser Ser Gly 130 135 140 Met Val Ala Gly Gly Val Tyr Trp Glu Ser Thr Phe Gly Gly Asp Tyr 145 150 155 160 15 Leu Leu Gly Met Wing He Val Wing Gly Val Thr Val Leu Tyr Thr Phe 165 170 175 He Gly Gly Phe Leu Wing Val Ser Tyr Thr Asp Wing Val Gln Gly Thr 180 185 190 He Met Phe Phe Ser Leu He He Val Val Pro Met Wing Tyr Phe Wing 195 200 205 Leu Ala Asn Pro Met Asp He Trp Ser Phe Wing Asn Ser Asn Asp Tyr 210 215 220 • Gly Pro His Thr Asp Gly He Gly Asn Pro Thr Tyr Phe Ser Met He 225 230 235 240 Ser Gly He Ser Ala Ala Ala He He Gly Asn Leu Gly Trp Gly Leu 20 245 250 255 Gly Tyr Phe Gly Gln Pro His He Val Val Arg Phe Met Ala Leu Arg 260 265 270 Thr Pro Wing Glu Wing Lys Gln Gly Arg Arg He Gly He Ser Trp Met 275 280 285 He He Cys Leu He Gly Wing Thr Phe Thr Wing He He Ser Thr Val 290 295 300 Phe Phe Wing Gln Asn Pro Asp Wing Asn He Thr Asp Thr Arg Wing Tyr 305 310 315 320 Glu Ser He Phe Leu Asp Leu Wing Arg Met Leu Phe His Pro Leu He 325 330 335 Wing Gly Leu He Leu Thr Wing Val Leu Wing Wing He Met Met Thr Met 25 340 345 350 s-.tei ^ A. «tk Being Ser Gln Leu Leu Val Thr Wing Being Ser Leu He Glu Asp Leu Leu 355 360 365 Lys Val Val Lys Lys Asp Ser Leu Ser Glu Arg Thr Leu He Met Leu 370 375 380 Ser Arg Wing Thr Val He He Leu Wing He Wing Wing Wing Wing Met Wing 385 390 395 400 He Asn Pro Being Asp Being He Leu Gly Leu Val Gly Phe Wing Trp Wing 405 410 415 Gly Phe Gly Being Wing Phe Gly Pro He He Leu Wing Being Leu Tyr Trp • 420 425 430 Lys Arg Leu Asn Wing Wing Gly Wing He Be Gly Met He Thr Gly Wing 435 440 445 He Val Ser He Wing Trp Gly Met Ser Pro Leu Ser Asp Thr Leu Tyr 450 455 460 Glu He He Pro Gly Phe Ala Leu Ala Thr He Val Val Val Val 465 470 475 480 Ser Leu Leu Thr Lys Glu Pro Ser Glu Glu He Leu Asn Glu Phe Glu 485 490 495 Thr Ala Lys Asp Leu Ala Ala Ala Val Glu Ser Asn Glu Asp Val Asp 500 505 510 10 Phe Ala Asp Ala Ala Gln Lys Leu Ser Lys Glu Ser 515 520 < 210 > 497 < 211 > 1476 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1453) < 223 > RXA00591 15 < 400 > 497 gcaacgccac; aggcaaaal: c caaaatgaaca tectgetgaga cttcaccatc < ? ccgtttcat 60 aaacccccca acgttcaettt g; aaaacactt. gg; agaat 2gca atg act here tet tcc 115 Met Thr Thr Ser Ser 1 5 here gct tcg ccg ate gct gaa tta caa aac etc age ccg aag caa aga 163 Thr Wing Pro Pro Wing Wing Glu Leu Gln Asn Leu Ser Pro Lys Gln Arg 10 15 20 ^ aaa tea gaa tcc cgg cgc gcg att ata tcc age tac tg gcc tcc acg 211 Lys Ser Glu Ser Arg Arg Ala He He Ser Ser Tyr Leu Gly Ser Thr 25 30 35 20 ate gag ttc tat gac ttc ctg tta tat gcc gc gcc tcc gcg acg gta 259 He Glu Phe Tyr Asp Phe Leu Leu Tyr Wing Wing Wing wing Thr Val 40 45 50 ttc ccc gca gtg ttc ttt acc aat etc gat ccg ctg gct gga acc att 307 Phe Pro Wing Val Phe Phe Thr Asn Leu Asp Pro Leu Wing Gly Thr He 55 60 65 gcc gcc tac gga acc ttc gcc gca ggt tat tta gct agg cca ctt ggt 355 Ala Ala Tyr Gly Thr Phe Wing Wing Gly Tyr Leu Wing Arg Pro Leu Gly 70 75 80 85 gga gca ate ttc gga drops ttc ggt gac cgt ctt gga cgc aag aag atg 403 Gly Wing He Phe Gly His Phe Gly Asp Arg Leu Gly Arg Lys Lys Met 90 95 100 25 ctt gtg ttg tcc atg etc ate atg ggt gtg gca tcc here tgc ate ggc 451 .IAÍJ AJ Leu Val Leu Ser Met Leu He Met Gly Val Ala Ser Thr Cys He Gly 105 110 115 ctt gtc cca age gct gaa atg ate gga age atg ggc gcg gta ate ctg 499 Leu Val Pro Ser Ala Glu Met He Gly Ser Met Gly Ala Val Le Leu 120 125 130 ate atg ctg cgc ate tgc cag ggc ate gct ggt ggc ggc gaa tgg ggc 547 He Met Leu Arg He Cys Gln Gly He Wing Val Gly Gly Glu Trp Gly 135 140 145 gga gct gcc etc atg gcg etc gag falls tea gat tcc aag aag cgc gga 595 • Gly Wing Wing Leu Met Wing Leu Glu His Ser Asp Ser Lys Lys Arg Gly 150 155 160 165 ttc gcc gcc tcc ttc acc aac gct ggt gca cca acc ggc gct gca ctg 643 Phe Wing Wing Being Phe Thr Asn Wing Gly Wing Pro Thr Gly Ala Ala Leu 170 175 180 gga acc ttc gcg etc ggt acc gca tet gct gtt etc acc cag gag ca 691 Gly Thr Phe Wing Leu Gly Thr Wing Being Wing Val Leu Thr Gln Glu Gln 185 190 195 ttc ctt tea tgg ggt tgg cgc ate cca ttc ctg etc tet ttc gtt ctg 739 Phe Leu Ser Trp Gly Trp Arg He Pro Phe Leu Leu Ser Phe Val Leu 200 205 210 10 ctg att gtc ggc ttg gtt ate cgc gcg aaa gtt age gaa tea cca ctg 787 Leu He Val Gly Leu Val He Arg Wing Lys Val Ser Glu Ser Pro Leu 215 220 225 ttc gca gct gca gcg gcc gcc gaa aaa gcc aag cca acc gaa cgt aaa 835 • Phe Ala Ala Ala Ala Ala Ala Glu Lys Ala Lys Pro Thr Glu Arg Lys 230 235 240 245 gtc ccc etc ttg cag gtt ctt cgc cga cca aag gca ctg ate ttg acc 883 Val Pro Leu Leu Gln Val Leu Arg Arg Pro Lys Ala Leu He Leu Thr 250 255 260 atg ctt ggc ggc gca tea gga ttc gga ctt ca gtt etc ttg tcc acc 931 Met Leu Gly Gly Wing Be Gly Phe Gly Leu Gln Val Leu Leu Ser Thr 265 270 275 15 ttc tcc ate age tac gca here ca g tc ggc ate gaa aga tc age gtc 979 Phe Ser Be Tyr Ala Thr Gln Ser Gly He Glu Arg Ser Ser Val 280 285 290 etc tac gcc ttc gca gtc gcc tea gtg ttc tet gtc ttc ttt gtg ate 1027 Phe Tyr Leu Ala Val Ala Val Ala Ser Ser Phe Val Phe Phe Val've 295,300,305 etc ttc GGT CGC gta ttc gga aka gac etc CGC CGA ccc atg ate gtc 1075 Phe Leu Arg Gly Asp Ser Val Leu Phe Arg Gly Arg Val Pro I Met 310315320325 • ate GCG GTG ttc ctg etc gta gcc tac CTG CGG CCG GCA ttc ttc atg 1123 He Ala Ala Leu Val Leu Phe Val Ala Tyr Leu Pro Ala Phe Phe Arg Met 330 335 340 20 etc acc tea gac aac tgg ttc ate ctg etc tcg gca ttc acc ate gcg 1171 Leu Thr Ser Asp Asn Trp Phe He Leu Leu Ser Wing Phe Thr He Wing 345 350 355 etc gca etc falls gcc atg ctt tac ggc cca cta gca gcg ttt ate tcc 1219 His Leu Leu Ala Tyr Gly Leu Ala Met Ala Pro Leu Ala Phe Ser He 360365370 gaa ttc gga caá acc aka tac GCG CGC here GGC CTG GGT GCA aka tac 1267 Gln Glu Gly Phe Ser Thr Ala Arg Gly Thr Tyr Ala Gly Ser Leu Tyr 375 380 385 cag acg gcc ttg gca ggt gga ate etc ttc acc cca acc gct ctg ate 1315 Gln Leu Wing Thr Leu He Gly Wing Gly Phe Thr Pro Thr He Leu Wing 390 - 395 400 405 25 age etc tac gcg gga cca ggc ggc gga acc tet gtc acc cca gtc ate 1363 Ser Leu Tyr Wing Gly Pro Gly Gly Gly Thr Ser Val Thr Pro Val He 410 415 420 gtc ttc etc gca acg atg tcc cta gtg tcc ate ate gcc ate gca ate 1411 Val Phe Leu Wing Thr Met Ser Leu Val Ser He He Wing Wing Wing 425 430 435 acc aga gaa tea aaa gac falls gat ctt tet act tac gaa drops 1453 Thr Arg Glu Ser Lys Asp His Asp Leu Ser Thr Tyr Glu His 440 445 450 taaggggacg atagggtcaa ttt 1476 < 210 > 498 < 211 > 451 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 498 Met Thr Thr Ser Ser Thr Wing Ser Pro He Wing Glu Leu Gln Asn Leu 1 5 10 15 Ser Pro Lys Gln Arg Lys Ser Glu Ser Arg Arg Wing He Be Ser 20 25 30 Tyr Leu Gly Ser Thr He Glu Phe Tyr Asp Phe Leu Leu Tyr Ala Wing 35 40 45 Wing Be Wing Thr Val Phe Pro Wing Val Phe Phe Thr Asn Leu Asp Pro 50 55 60 Leu Wing Gly Thr He Wing Wing Tyr Gly Thr Phe Wing Wing Gly Tyr Leu 65 70 75 80 Wing Arg Pro Leu Gly Gly Wing He Phe Gly His Phe Gly Asp Arg Leu 85 90 95 Gly Arg Lys Lys Met Leu Val Leu Ser Met Leu He Met Gly Val Wing 100 105 110 Being Thr Cys He Gly Leu Val Pro Being Wing Glu Met He Gly Ser Met 115 120 125 Gly Wing Val He Leu He Met Leu Arg He Cys Gln Gly He Wing Val 130 135 140 Gly Gly Glu Trp Gly Gly Wing Wing Leu Met Wing Leu Glu His Ser Asp 145 150 155 160 Ser Lys Lys Arg Gly Phe Ala Ala Be Phe Thr Asn Ala Gly Ala Pro 165 170 175 Thr Gly Ala Ala Leu Gly Thr Phe Ala Leu Gly Thr Ala Ser Ala Val 180 185 190 Leu Thr Gln Glu Gln Phe Leu Ser Trp Gly Trp Arg He Pro Phe Leu 195 200 205 Leu S er Phe Val Leu Leu Ue Val Gly Leu Val He Arg Ala Lys Val 210 215 220 Ser Glu Ser Pro Leu Phe Ala Ala Ala Ala Ala Ala Glu Lys Ala Lys 225 230 235 240 Pro Thr Glu Arg Lys Val Pro Leu Leu Gln Val Leu Arg Arg Pro Lys 245 250 255 Wing Leu He Leu Thr Met Leu Gly Gly Wing Ser Gly Phe Gly Leu Gln 260 265 270 Val Leu Leu Ser Thr Phe Ser Be Ser Tyr Wing Thr Gln Ser Gly He 275 280 285 Glu Arg Ser Ser Val Leu Tyr Ala Phe Ala Ala Ala Ser Val Phe Ser 290 295 300 Val Phe Phe Val He Leu Phe Gly Arg Val Ser Asp Leu Phe Gly Arg 305 310 315 320 Arg Pro Val Met He He Ala Ala Val Leu Phe Val Ala Ala Tyr Leu Pro 325 330 335 Wing Phe Phe Arg Met Leu Thr Ser Asp Asn Trp Phe He Leu Leu Ser 340 345 350 Wing Phe Thr He Wing Leu Wing Leu His Wing Met Leu Tyr Gly Pro Leu 355 360 365 Wing Wing Phe He Ser Glu Gln Phe Gly Thr Ser Wing Arg Tyr Thr Gly 370 375 380 Wing Being Leu Gly Tyr Gln Leu Wing Thr Leu He Gly Wing Gly Phe Thr 385 390 395 400 • Pro Thr He Leu Wing Being Leu Tyr Wing Gly Pro Gly Gly Gly Thr Ser 4 05 410 415 Val Thr Pro Val He Val Phe Leu Wing Thr Met Ser Leu Val Ser He 420 425 430 He Wing Wing He Thr Arg Glu Ser Lys Asp His Asp Leu Ser Thr 435 440 445 Tyr Glu His 450 < 210 > 499 < 211 > 1635 < 212 > DNA 10 < 213 > Corynebacterium glutamicum < 220 > • < 221 > CDS < 222 > (101) .. (1612) < 223 > RXA01629 < 400 > 499 caggaagaag 'ttaa < caccgc ccaggggtgt 2 gttggatgat gat < ? atctac; aaacaaacat 60 tccgtta-tgc actcataatga t < atgacgaga ggttttactc gtg age ccg att cgc 115 Val Ser Pro He Arg 15 1 5 tea aaa aag aaa aa g aac a ga cca aga cta a gtac gat gac gtc 163 Ser Lys Lys He Lys Asn Glu Pro Arg Leu Thr Val Asp Asp Val 10 15 20 aac gtt gtt ccc cca aag aag ate cgt ccg gcc att aaa ggc act gtg 211 Asn Val Val Pro Pro Lys He Arg Pro Ala He Lys Gly Thr Val 25 30 35 gtg ggt aac ttc atg gag tgg tac gac ttc gga att tat ggt tat ttg 259 Val Gly Asn Phe Met Glu Trp Tyr Asp Phe Gly He Tyr Gly Tyr Leu • 40 45 50 acg gtc acg atg acc gca gta ttt acc ca gcc ctg ccg caa gaa tgg 307 Thr Val Thr Met Thr Ala Val Phe Thr Gln Gly Leu Pro Gln Glu Trp 20 55 60 65 cag ttg ttg gcc gtg atg ttt ggt ttc gcg gtg tet tat tta gtt cgc 355 Gln Leu Leu Ala Val Met Phe Gly Phe Ala Val Ser Tyr Leu Val Arg 70 75 80 85 ccg ctt ggt ggc ctg gtt ctg ggt ccg ctt ggc gat aag gtt ggc cgc 403 Pro Leu Gly Gly Leu Val Leu Gly Pro Leu Gly Asp Lys Val Gly Arg 90 95 100 cag aag gtt ttg tac gta acc atg gcc atg atg gcc gtg tet acg gcg 451 Gln Lys Val Leu Tyr Val Thr Met Wing Met Met Wing Val Ser Thr Wing 105 110 115 ctg att ggc ttg ctg ccg acg gcg gcg tcg ata ggc gct tgg gct ttg 499 Leu He Gly Leu Leu Pro Thr Wing Ala Ser He Gly Ala Trp Ala Leu 25 120 125 130 ÍY .A Aji &,. i t 't gtg ctt ttg tac ctg a tg atg gg tg cag gga ttt tcg act ggt ggt 547 Val Leu Leu Tyr Leu Leu Lys Met Val Gln Gly Phe Ser Thr Gly Gly 135 140 145 gaa tat gct ggt gcg acc action gtt gtt gag ttt gcg ccg gat cgt 595 Glu Tyr Wing Gly Wing Thr Thi Tyr Val Wing Glu Phe Wing Pro Asp Arg 150 155 160 165 cga cga ggt ttc ttc gt gct ttc cta gat atg ggt tcc tac ctg ggc 643 Arg Arg Gly Phe Phe Gly Wing Phe Leu Asp Met Gly Ser Tyr Leu Gly 170 175 180 ttt gcc gcg ggt gct tcg gtc gtg gcg att act tgg gtg acc act 691 Phe Wing Wing Gly Wing Ser Val Val Wing He Thr Thr Trp Val Thr Thr 185 190 195 falls ttc tat ggc gca act gcc atg gag gat ttc ggt tgg cgt att ect 739 His Phe Tyr Gly Ala Thr Wing Met Glu Asp Phe Gly Trp Arg He Pro 200 205 210 ttc ctg act gcg ate ccg ctg ggc ate att gcg gtg tac ctg cgt act 787 Phe Leu Thr Wing Pro Pro Leu Gly He He Wing Val Tyr Leu Arg Thr 215 220 225 cgt ate ect gact acc ect gcg ttt gag aac aac aac ca gac gac cca aat 835 Arg He Pro Glu Thr Pro Wing Phe Glu Asn Asn Gln Asp Glu Pro Asn 230 235 240 245 gca gtt gtt gaa aag gac act gaa gat ect tat gca cgc ctg ggc ctg 883 Wing Val Val Glu Lys Asp Thr Glu Asp Pro Tyr Al to Arg Leu Gly Leu 250 255 260 gct ggt gtt ate cgc falls drops tgg cgt cca ctg ctg att ggt att gcg 931 Wing Gly Val He Arg His His Trp Arg Pro Leu Leu He Gly He Wing 265 270 275 att gtg gca gcg acc aac acc gcc ggt tac gcg cta acc agt tac atg 979 He Val Ala Ala Thr Asn Thr Ala Gly Tyr Ala Leu Thr Ser Tyr Met 280 285 290 ect gtg tat cta gag gag cag ate ggt ctg falls tcc gcc tcc gct gcc 1027 Pro Val Tyr Leu Glu Glu Gln He Gly Leu His Ser Wing Wing Wing 295 300 305 gct gtg acc gtg ccg att ctg gtt gtt atg tcc ctg ctg ctg cca ttt 1075 Wing Val Thr Val Pro He Leu Val Val Met Ser Leu Leu Pro Phe 310 315 320 325 gtt ggt atg tgg agt gac cgc gtg ggc cgc aag ect gtc tac gcg act 1123 Val Gly Met Trp Ser Asp Arg Val Gly Arg Lys Pro Val Tyr Ala Thr 330 335 340 gct gtt gcg gca acg ctg ate ttg atg gtt ect gcc ttc ttg ate atg 1171 Wing Val Wing Wing Thr Leu He Leu Met Val Pro Wing Phe Leu He Met 345 350 355 aac acc gga acc ate ggc gcc gta ctg att gca ctg tcc atg gtt gct 1219 Asn Thr Gly Thr He Gly Wing Val Leu He Wing Leu Ser Met Val Wing 360 365 370 att cca acc ggt ttg tat gtg gca ctg tcc gca tet gcc ctg cca gcg 1267 He Pro Thr Gly Leu Tyr Val Wing Leu Ser Wing Being Wing Leu Pro Wing 375 380 385 ctg ttc cca acc gcg tea cga ttc tet gga atg ggt att tcc tac aac 1315 Leu Phe Pro Thr Wing Ser Arg Phe Ser Gly Met Gly He Ser Tyr Asn 390 395 400 405 att tcc gtg tcg ttg ttc ggt ggt here acc ccg ctg ate acc cag ttc 1363 He Ser Val Ser Leu Phe Gly Gly Thr Thr Pro Leu He Thr Gln Phe 410 415 420 ctg ctg cag aag act ggc ctg gat ate gtt cca gcg etc tac ate atg 1411 Leu Leu Gln Lys Thr Gly Leu Asp He Val Pro Ala Leu Tyr He Met 425 430 435 ttc ttc tet gt gt gt gt gt gtg ctg ctg ctg ttc atg acc gag tet 1459 phe phe be wing he has wing gly val wing p leu leu phe met thr glu be 440 445 450 tea cag aag cca ctg ctt ggc tea ttc cca acc gtg gaa acc aag tet 1507 Ser Gln Lys Pro Leu Leu Gly Ser Phe Pro Thr Val Glu Thr Lys Ser 455 460 465 gag gcc gtg gag ate gtg aag aac cag gac gag gat cca aat att gat 1555 Glu Ala Val Glu He Val Lys Ásn Gln Asp Glu Asp Pro Asn Asp 470 475 480 485 ctt tcc cat atg ccg ttt ect gat gag gaa aac gta ggt gct gaa aag 1603 Leu Ser His Met Pro Pro Phe Pro Aslu Glu Glu Asn Val Gly Ala Glu Lys 490 495 500 caa aac gca taaccgtaaa gcccgctgca agg 1635 Gln Asn Ala < 210 > 500 < 211 > 504 < 212 > PRT < 213 > Corynebacterium glutamicum 10 < 400 > 500 Val Ser Pro He Arg Ser Lys Lys He Lys Asn Glu Pro Arg Leu 1 5 10 15 • Thr Val Asp Asp Val Asn Val Val Pro Pro Lys He Arg Pro Wing 20 25 30 He Lys Gly Thr Val Val Gly Asn Phe Met Glu Trp Tyr Asp Phe Gly 35 40 45 He Tyr Gly Tyr Leu Thr Val Thr Met Thr Wing Val Phe Thr Gln Gly 50 55 60 Leu Pro Gln Glu Trp Gln Leu Leu Wing Val Met Phe Gly Phe Wing Val 65 70 75 80 Ser Tyr Leu Val Arg Pro Leu Gly Gly Leu Val Leu Gly Pro Leu Gly 15 85 90 95 Asp Lys Val Gly Arg Gln Lys Val Leu Tyr Val Thr Met Wing Met Met 100 105 110 Wing Val Ser Thr Wing Leu He Gly Leu Leu Pro Thr Ala Ala Ser He 115 120 125 Gly Ala Trp Ala Leu Val Leu Leu Tyr Leu Leu Lys Met Val Gln Gly 130 135 140 Phe Ser Thr Gly Gly Glu Tyr Ala Gly Ala Thr Thr Tyr Val Ala Glu 145 150 155 160 Phe Ala Pro Asp Arg Arg Arg Gly Phe Phe Gly Wing Phe Leu Asp Met 165 170 175 20 Gly Ser Tyr Leu Gly Phe Wing Wing Gly Wing Val Val Wing He Thr 180 185 190 Thr Trp Val Thr Thr His Phe Tyr Gly Wing Thr Wing Met Glu Asp Phe 1 95 200 205 Gly Trp Arg He Pro Phe Leu Thr Wing He Pro Leu Gly He He Wing 210 215 220 Val Tyr Leu Arg Thr Arg He Pro Glu Thr Pro Wing Phe Glu Asn Asn 225 230 235 240 Gln Asp Glu Pro Asn Wing Val Val Glu Lys Asp Thr Glu Asp Pro Tyr 245 250 255 Wing Arg Leu Gly Leu Wing Gly Val He Arg His His Trp Arg Pro Leu 260 265 270 25 Leu He Gly He Wing He Val Wing Wing Thr Asn Thr Wing Gly Tyr Wing - "II TfflífiiÉ5 ^ ***" -, *. *. * Ir. *. -i. ^ R. ^,, ..... _, _. «,. - 275 280 285 Leu Thr Ser Tyr Met Pro Val Tyr Leu Glu Glu Gln He Gly Leu His 290 295 300 Be Ala Be Ala Ala Ala Val Thr Val Pro He Leu Val Val Met Ser 305 310 315 320 Leu Leu Pro Phe Val Gly Met Trp Ser Asp Arg Val Gly Arg Lys 325 330 335 Pro Val Tyr Ala Thr Ala Val Ala Ala Thr Leu He Leu Met Val Pro 340 345 350 • Wing Phe Leu He Met Asn Thr Gly Thr He Gly Wing Val Leu He Wing 355 360 365 Leu Ser Met Val Wing He Pro Thr Gly Leu Tyr Val Wing Leu Ser Wing 370 375 380 Be Ala Leu Pro Ala Leu Phe Pro Thr Wing Being Arg Phe Ser Gly Met 385 390 395 400 Gly He Ser Tyr Asn He Ser Val Ser Leu Phe Gly Gly Thr Thr Pro 405 410 415 Leu He Thr Gln Phe Leu Leu Gln Lys Thr Gly Leu Asp He Val Pro 420 425 430 Wing Leu Tyr He Met Phe Phe Ser Wing Wing Wing Gly Val Wing Leu Leu 10 435 440 445 Phe Met Thr Glu Ser Ser Gln Lys Pro Leu Leu Gly Ser Phe Pro Thr 450 455 460 Val Glu Thr Lys Ser Glu Ala Val Glu He Val Lys Asn Gln Asp Glu 465 470 475 480 Asp As Asn Asp Leu As His Met Pro As Pro Phe Pro Aslu Glu Glu Asn 485 490 495 Val Gly Ala Glu Lys Gln Asn Ala 500 < 210 > 501 < 211 > 1509 15 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1486) < 223 > RXA02030 < 400 > 501 • gcgcctaaca tctcattgta tgggattgac tetaataate tcctgtggaa acatcgcaag 60 ggtaattatt ggaatetatt attgtgtgag gegataaetc gtg ac ac act 115 Val Thr Thr Thr Asp 20 1 5 falls tcc acg gag ttg aat ect tet gat cca ggt ggg cag acg gca acc 163 His Ser Thr Glu Leu Asn Pro Ser Asp Pro Gly Gly Gln Thr Wing Thr 10 15 20 cta gtg att gac aag aaa act aaa cgt cgg gtt gca gca gcc tcc acc 211 Leu Val He Asp Lys Lys Thr Lys Arg Arg Val Wing Wing Ala Ser Thr 25 30 35 ate ggc here acc ate gag ttc tac gat ttt tat gcg tac gcg gcg gca 259 He Gly Thr Thr He Glu Phe Tyr Asp Phe Tyr Wing Tyr Wing Wing Wing 40 45 50 gct gtc gtt gtt ttc cca agt ctg ttt ttc ect gcc aat gac aac cca 307 Wing Val Val Val Phe Pro Ser Leu Phe Phe Pro Wing Asn Asp Asn Pro 25 55 60 65 íiaütr ~ t -i acc gtg aac ctg ttg gca tcg ttt gcc acc ttt ggt ctt gcg ttc gtt 355 Thr Val Asn Leu Leu Wing Ser Phe Wing Thr Phe Gly Leu Wing Phe Val 70 75 80 85 gct cgt cca etc ggt tea ate att ttc ggg drops ttc ggt gac cgt gtg 403 Wing Arg Pro Leu Gly Ser He He Phe Gly His Phe Gly Asp Arg Val 90 95 100 gga cgc aaa gct acc ttg ate ggt tea ctg ctg acc atg ggc att gcc 451 Gly Arg Lys Wing Thr Leu He Gly Ser Leu Leu Thr Met Gly He Wing 105 110 115 acc ate ttg ate ggc ctg ctgct act tat ggt cag gtc gga ate att 499 Thr He Leu He Gly Leu Leu Pro Thr Tyr Gly Gln Val Gly He He 120 125 130 gca ccg gcg ctg ttg gcg etc atg cgt ttc tgc cag ggc ctg ggc ctt 547 Ala Pro Ala Leu Leu Ala Leu Met Arg Phe Cys Gln Gly Leu Gly Leu 135 140 145 ggc ggt gaa tgg tet ggc gct gcg ttg ctg gct ggt gaa aac gcg gaa 595 Gly Gly Glu Trp Ser Gly Ala Ala Leu Leu Ala Gly Glu Asn Ala Glu 150 155 160 165 aac act falls cgc gct cgt gct gca atg tgg cca cag ctg ggt gca ccg 643 Asn Thr His Arg Wing Arg Wing Wing Met Trp Pro Gln Leu Gly Wing Pro 170 175 180 ttt ggt ttc ttc ttg gcc aat ggt ttc atg etc att ctg gtc ggt gtg 691 Phe Gly Phe Phe Leu Wing Asn Gly Phe Met Leu He Leu Val Gly Val 185 190 195 ctt gcc cat cag gac ggc gat ctt fall ggc gcg ttc atg acc tgg ggt 739 Leu Ala His Gln Asp Gly Asp Leu His Gly Wing Phe Met Thr Trp Gly 200 205 210 tgg cgt ctg cca ttc ctg tet tcg gcg ate atg ate gca gtt ggc ctg 787 Trp Arg Leu Pro Phe Leu Ser Be Ala He Met He Ala Val Gly Leu 215 220 225 tgg gtg cgt ttc tea ctg gag gaa act cca gtg ttc aag cag gct gtt 835 Trp Val Arg Phe Ser Leu Glu Glu Thr Pro Val Phe Lys Gln Ala Val 230 235 240 245 gat cag ggc aag aag gtg aag tet ccg etc aag gag ctg ttc aag act 883 Asp Gln Gly Lys Lys Val Lys Ser Pro Leu Lys Glu Leu Phe Lys Thr 250 255 260 tcc ect ggc ect gtt gtg cag gct act ttg ate atg ctg tcc act tat 931 Ser Pro Gly Pro Val Val Gln Wing Thr Leu He Met Leu Ser Thr Tyr 265 270 275 acc ttc tc tc ccg gtt acc acc tgg att ctc tcg tat gcc ate ggt 979 Thr Leu Phe Tyr Leu Val Thr Thr Trp He Leu Ser Tyr Gly He Gly 280 285 290 aat cgc age acc gga aac ggc ctg tet att ccg tac ttt gag ttc ttg 1027 Asn Arg Ser Thr Gly Asn Gly Leu Ser He Pro Tyr Phe Glu Phe Leu 295 300 305 cag ttg cag ctg gcc acc ate gtg ttc tcc gcc ate atg ate ect gtg 1075 Gln Leu Gln Leu Wing Thr He Val Phe Phe Wing He Met He Pro Val 310 315 320 325 tea ggc tgg ttg gct gat gtg tgg ggt cgt aaa aac acc ctg acc ttg 1123 Be Gly Trp Leu Wing Asp Val Trp Gly Arg Lys Asn Thr Leu Thr Leu 330 335 340 gct tet gtg ctg ctt etc ggc ttt ggt ctg act ttt aat ctg ctt etc 1171 Ala Ser Val Leu Leu Leu Gly Phe Gly Leu Thr Phe Asn Leu Leu Leu 345 350 355 gat cca gag acc gcc acc aag acc acc gtg ttc ate ttc ttg ttc gtg 1219 Asp Pro Glu Thr Wing Thr Lys Thr Thr Val Phe He Phe Leu Phe Val 360 365 370 ggc atg age ate atg ggt ctg ate ttt gga ccc atg tcg gca att ttg 1267 Gly Met Ser Met Met Gly Leu He Phe Gly Pro Met Ser Ala He Leu 375 380 385 ccg gag etc ttc ccc acc aac gtc cgc tac acg ggc tcc gga ate gcc 1315 Pro Glu Leu Phe Pro Thr Asn Val Arg Tyr Thr Gly Ser Gly He Wing 390 395 400 405 tac aat gtc tcc tcg ate etc ggt gca gc att gca ccg ttc ate gca 1363 Tyr Asn Val Ser Ser He Leu Gly Wing Wing He Wing Pro Phe He Wing 410 415 420 acg tgg ctg gtg tcc gag ttt tea gtg gcg tac gtc ggc tat tac etc 1411 Thr Trp Leu Val Ser Glu Phe Ser Val Ala Tyr Val Gly Tyr Tyr Leu 425 430 435 ate ate gtc acc gca att acc ttt gtt gcg gtg ctg acg atg aag gaa 1459 He He Val Thr Ala He Thr Phe Val Ala Val Leu Thr Met Lys Glu 440 445 450 aac aaa aac falls gac etc cga gag gtc taaaagattt ttgcttatcg 1506 Asn Lys Asn His Asp Leu Arg Glu Val 455 460 acg 1509 < 210 > 502 < 211 > 462 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 502 Val Thr Thr Thr Asp His Ser Thr Glu Leu Asn Pro Ser Asp Pro Gly 1 5 10 15 Gly Gln Thr Wing Thr Leu Val He Asp Lys Lys Thr Lys Arg Arg Val 20 25 30 Ala Ala Ala Ser Thr He Gly Thr Thr He Glu Phe Tyr Asp Phe Tyr 35 40 45 Wing Tyr Wing Wing Ala Wing Val Val Val Phe Pro Be Leu Phe Phe Pro 50 55 60 Wing Asn Asp Asn Pro Thr Val Asn Leu Leu Wing Ser Phe Wing Thr Phe 65 70 75 80 Gly Leu Wing Phe Val Wing Arg Pro Leu Gly Ser He He Phe Gly His 85 90 95 Phe Gly Asp Arg Val Gly Arg Lys Ala Thr Leu He Gly Ser Leu Leu 100 105 110 Thr Met Gly He Wing Thr He Leu He Gly Leu Leu Pro Thr Tyr Gly 115 120 125 Gln Val Gly He He Ala Pro Ala Leu Leu Ala Leu Met Arg Phe Cys 130 135 140 Gln Gly Leu Gly Leu Gly Gly Glu Trp Ser Gly Ala Ala Leu Leu Ala 145 150 155 160 Gly Glu Asn Ala Glu Asn Thr His Arg Ala Arg Ala Ala Met Trp Pro 165 170 175 Gln Leu Gly Wing Pro Phe Gly Phe Phe Leu Wing Asn Gly Phe Met Leu 180 185 190 He Leu Val Gly Val Leu Wing His Gln Asp Gly Asp Leu His Gly Wing 195 200 205 Phe Met Thr Trp Gly Trp Arg Leu Pro Phe Leu Ser Wing He Met 210 215 220 Wing Wing Val Gly Leu Trp Val Arg Phe Ser Leu Glu Glu Thr Pro Val 225 230 235 240 Phe Lys Gln Wing Val Asp Gln Gly Lys Lys Val Lys Ser Pro Leu Lys 245 250 255 Glu Leu Phe Lys T hr Ser Pro Gly Pro Val Val Gln Wing Thr Leu He 260 265 270 Met Leu Ser Thr Tyr Thr Leu Phe Tyr Leu Val Thr Thr Trp He Leu 275 280 285 Ser Tyr Gly He Gly Asn Arg Ser Thr Gly Asn Gly Leu Ser He Pro 290 295 300 Tyr Phe Glu Phe Leu Gln Leu Gln Leu Wing Thr Hee Val Phe Phe Wing 305 310 315 320 • He Met He Pro Val Ser Gly Trp Leu Wing Asp Val Trp Gly Arg Lys 325 330 335 Asn Thr Leu Thr Leu Wing Ser Val Leu Leu Leu Gly Phe Gly Leu Thr 340 345 350 Phe Asn Leu Leu Leu Asp Pro Glu Thr Wing Thr Lys Thr Thr Val Phe 355 360 365 He Phe Leu Phe Val Gly Met Ser He Met Met Gly Leu He Phe Gly Pro 370 375 380 Met Be Wing He Leu Pro Glu Leu Phe Pro Thr Asn Val Arg Tyr Thr 385 390 395 400 Gly Ser Gly He Wing Tyr Asn Val Ser Ser He Leu Gly Wing Wing He 10 405 410 415 Wing Pro Phe He Wing Thr Trp Leu Val Ser Glu Phe Ser Val Wing Tyr 420 425 430 Val Gly Tyr Tyr Leu He He Val Thr Wing He Thr Phe Val Wing Val 435 440 445 Leu Thr Met Lys Glu Asn Lys Asn His Asp Leu Arg Glu Val 450 455 460 <; 210 > 503 < 211 > 870 < 212 > DNA < 213 > Corynebacterium glutamicum 15 < 220 > < 221 > CDS < 222 > (101) .. (847) < 223 > RXA00186 < 400 > 503 agaageccag < ? attttgttt agctcacctc taaagctcct gatctggata < ^ gaggactcc 60 tgcggaaaac cgtgtggcta gtgaagctac ccggcatctc atg ggg gag aag act 115 # Met Gly Glu Lys Thr 5 tet gtc gcg tat gtt fall gat gtt ctg ate aag ggc gtg cca gtg cgg 163 20 Ser Val Ala Tyr Val His Asp Val Leu He Lys Gly Val Pro Val Arg 10 15 20 ata tac aat ccg cae ccc aac gac ggg cc g ctt ect gtc ttt ate tac 211 He Tyr Asn Pro His Pro Asn Asp Gly Pro Leu Pro Val Phe He Tyr 25 30 35 ttc cat ggt ggc gga tgg gtt ttg ggg gac ctt gaa tea gtg gat tcc 259 Phe His Gly Gly Gly Trp Val Leu Gly Asp Leu Glu Ser Val Asp Ser 40 45 50 gtg cgc gat gcc gtt gct tea ggc gcc ccg tgt ate agt gtg gtg 307 Thr Val Arg Asp He Wing Val Wing Ser Gly Wing Leu Cys He Ser Val 55 60 65 gat tat cgc cgt gca ccg gaa cat ect ttt etc gct gca ttg gat gat 355 25 Asp Tyr Arg Arg Ala Pro Glu His Pro Phe Leu Ala Ala Leu Asp Asp . I? 70 75 80 85 tgc ca gtg gtc acg gaa gct gtc etc aat ggt gaa etc gcc agt gct 403 Cys Gln Val Val Thr Glu Ala Val Leu Asn Gly Glu Leu Wing Ser Wing 90 95 100 aac cag cat cta gtg gca gtc ggc ggg gac age gcc ggt ggc aat att 451 Asn Gln His Leu Val Wing Val Gly Gly Asp Ser Wing Gly Gly Asn He 105 110 115 gcg gcg gtc ate gct ca g cag ctg cgc gat cag ate acc cae ca gtt 499 Ala Ala Val He Ala Gln Gln Leu Arg Asp Gln He Thr His Gln Val 120 125 130 ctt gtg tat ccg gtg atg gac gta ate ttg ctg gtg att tgt tet ate 547 Leu Val Tyr Pro Val Met Asp Val He Leu Leu Val He Cys Ser He 135 140 145 att acc act ggt ttt gcg ctg etc atg cat cca aag age aag gac aag 595 He Thr Thr Gly Phe Ala Leu Leu Met His Pro Lys Ser Lys Asp Lys 150 155 160 165 acg gag acg att tet gat gaa ttc etc gca gag ate ca gcg gga agt 643 Thr Glu Thr He Ser Asp Glu Phe Leu A a Glu He Gln Wing Gly Ser 170 175 180 gaa aag ate tcc att ctg cgt tcg acc ect gct gaa aaa gcc aat gcg 691 Glu Lys He Ser He Leu Arg Ser Thr Pro Wing Glu Lys Wing Asn Wing 10 185 190 195 age cgt tgg ate atg tac ttc gtt ggc gga att ggc ctg etc tac age 739 Be Arg Trp He Met Tyr Phe Val Gly Gly He Gly Leu Leu Tyr Ser • 200 205 210 gtg ttc age ctg tgg here ggt ggc gta acc gga ctg acg ttg aac tcc 787 Val Phe Ser Leu Trp Thr Gly Gly Val Thr Gly Leu Thr Leu Asn Ser 215 220 225 ttc aac ttc ctg ttc ctg tea ote ggc atg gtg etc acc gct aat tac 835 Phe Asn Phe Leu Phe Leu Ser Leu Gly Met Val Leu Thr Wing Asn Tyr 230 235 240 245 ggg cca gag tat taagcaaagc ttatt; cgcga agg? 70 Gly Pro Glu Tyr 15 < 210 > 504 < 211 > 249 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 504 ^^ Met Gly Glu Lys Thr Ser Val Ala Tyr Val His Asp Val Leu He Lys 1 5 10 15 Gly Val Pro Val Arg He Tyr Asn Pro His Pro Asn Asp Gly Pro Leu 20 20 25 30 Pro Val Phe He Tyr Phe His Gly Gly G Trp Val Leu Gly Asp Leu 35 40 45 Glu Ser Val Asp Ser Thr Val Arg Asp He Wing Val Wing Ser Gly Wing 50 55 60 Leu Cys He Ser Val Asp Tyr Arg Arg Wing Pro Glu His Pro Phe Leu 65 70 75 80 Wing Ala Leu Asp Asp Cys Gln Val Val Thr Glu Wing Val Leu Asn Gly 85 - 90 95 Glu Leu Wing Ser Wing Asn Gln His Leu Val Wing Val Gly Gly Asp Ser 100 105 110 Wing Gly Gly Asn He Wing Wing Val He Wing Gln Gln Leu Arg Asp Gln 25 115 120 125 He Thr His Gln Val Leu Val Tyr Pro Val Met Asp Val He Leu Leu 130 135 140 Val He Cys Ser He He Thr Thr Gly Phe Ala Leu Leu Met His Pro 145 150 155 160 Lys Being Lys Asp Lys Thr Glu Thr He Being Asp Glu Phe Leu Wing Glu 165 170 175 He Gln Wing Gly Ser Glu Lys He Ser He Leu Arg Ser Thr Pro Wing 180 185 190 Glu Lys Wing Asn Wing Being Arg Trp He Met Tyr Phe Val Gly Gly He • 195 200 205 Gly Leu Leu Tyr Ser Val Phe Ser Leu Trp Thr Gly Val Thr Gly 210 215 220 Leu Thr Leu Asn Ser Phe Asn Phe Leu Phe Leu Ser Leu Gly Met Val 225 230 235 240 Leu Thr Wing Asn Tyr Gly Pro Glu Tyr 245 < 210 > 505 < 211 > 468 < 212 > DNA 10 < 213 > Corynebact: erium glutamicum < 220 > < 221 > CDS • < 222 > (101) .. (451) < 223 > RXA00187 < 400 > 505 gctitatticgc < gaaggcattcc aagga; acgtg gggattcatt cttcaattcc 60 aggcattttc < gggttgattt ct -ttcaccgg tctgggtgtt gtg ate tcc gga ttt 115 Val He Ser Gly Phe 1 5 15 ttc acc tcg att tcc acg gca acc acg tgg ect gtc ate gcg ttc etc 163 Phe Thr Ser He SerThr Wing Thr Thr Trp Pro Val He Wing Phe Leu io 15 20 tac tet gga ctg etc aac ate gcg gtg ect tea ggt ggc tcg aaa ttc 211 Tyr Ser Gly Leu Leu Asn He Wing Val Pro Ser Gly Gly Ser Lys Phe 25 30 35 ate ate gaa gcc ccg tac ate ate cca acc cca gtg gat ctt ggc gct 259 He He Glu Wing Pro Tyr He He Pro Thr Pro Val Asp Leu Gly Wing 40 45 50 • gac atg ggc ctt gtc ctg cag gct tat ca gtg at gt ggc gat gcg acc 307 Asp Met Gly Leu Val Leu Gln Wing Tyr Gln Met Being Asp Gly Wing Thr 55 60 65 20 aac ctg etc att ccg ttc ttc gcg ctg cca tat ttg gcc aat ttc aag 355 Asn Leu Leu He Pro Phe Phe Wing Leu Pro Tyr Leu Wing Asn Phe Lys 70 75 80 85 tie aaa ttc age ca g gg gtg ggc tat here gtt ccg ect gtc etc gtt 403 He Lys Phe Ser Gln Val Val Gly Tyr Thr Val Pro Pro Val Leu Val 90 95 100 gtt ate gcc gtg ate tgc att tac ctg ttc ctg cga gca tea ate att 451 Val He Ala Val He Cys He Tyr Leu Phe Leu Arg Ala Ser He He 105 110 115 taaaaagatg cttctcg 468 < 210 > 506 25 < 211 > 117" .-to . I < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 506 Val He Ser Gly Phe Phe Thr Be He Be Thr Wing Thr Thr Trp Pro 1 5 10 15 Val He Wing Phe Leu Tyr Ser Gly Leu Leu Asn He Wing Val Pro Ser 20 25 30 Gly Gly Ser Lys Phe He He Glu Wing Pro Tyr He He Pro Thr Pro 35 40 45 Val Asp Leu Gly Wing Asp Met Gly Leu Val Leu Gln Wing Tyr Gln Met 50 55 60 Ser Asp Gly Wing Thr Asn Leu Leu He Pro Phe Phe Wing Leu Pro Tyr 65 70 75 80 Leu Wing Asn Phe Lys He Lys Phe Ser Gln Val Val Gly Tyr Thr Val 85 90 95 Pro Pro Val Leu Val Val He Wing Val He Cys He Tyr Leu Phe Leu 100 105 110 Arg Ala Ser He He 115 10 < 210 > 507 < 211 > 1329 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1306) < 223 > RXA01667 < 400 > 507 15 tctcggcgtt gatgatcatc cgcaatatca tgccgccgca agattceget tttccagact 60 ttgetcatte cttcctctat tactgctcgc catcatcggc atg att ttg ggg ect 115 Met He Leu Gly Pro 1 5 aag gtg ttg ggt ctg att ggt tgg tcg gat cat ctt tcc act tac act 163 Lys Val Leu Gly Leu He Gly Trp Ser Asp His Leu Ser Thr Tyr Thr 10 15 20 acg gtg etc att gcg att gtg ttt gct tcg atg ccg tat tcg atg aag 211 Thr Val Leu He Wing He Val Phe Wing Ser Met Pro Tyr Ser Met Lys • 25 30 35 tttttt ggaacc ccggtt ggggcc ggttgg ccggtt aacctt ggggcc aattgg aaaagg aaccgg atg tgg ggccgg ttaatt tcg 259 Phe Asp Arg Gly Val Arg Thr Gly Met Lys Thr Met Trp Wing Tyr Ser 20 4400 45 50 aacctt ggccgg aaatttggg ttt gtg ggg cag tgg ggt ctg ttc att ttg ctg ggt ctg 307 T Thhrr A Allaa MMMeeettt Phe Val Gly Gln Trp Gly Leu Phe He Leu Leu Gly Leu 5 555 60 65 tttttt ttttgg ttttttccc ccaaaa ccg gtg tgg ggt acc gat gag tgg ttc ggc atg atg 355 P Phhee L Leeuu PPPhhheee GGllnn Pro Val Trp Gly Thr Asp Glu Trp Phe Gly Met Met 7 700 75 80 85 ttttgg ccccgg ggtttt ggggtt ttt gtt ggt ggt ttt ggt act gct gcg gtg ggt 403 L Leeuu P Prroo VVaall GGllyy Phe Val Gly Gly Phe Gly Thr Wing Wing Wing Val Gly 90 95 100 aacctt ggccgg ttttgg ggaagg tet tcg ggt gcg gag gct gcg atg tet ttg ggc ttt 451 Thr Ala Leu Glu Be Ser Gly Ala Glu Ala Ala Met Ser Leu Gly Phe 25 105 110 115 • ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Gly Thr Phe Wing Wing Val Gly Gly He He 120 125 130 ttc here acg tgg ggt att aag aag ggc aag gcg gcg atg ect gcg 547 Phe Thr Thr Trp Gly He Lys Lys Gly Lys Thr Ala Wing Met Pro Wing 135 140 145 cag ttg ccg tgg gat ttg cgt tcg ggt tat ate gat aag ctg agt gat 595 Gln Leu Pro Trp Asp Leu Arg Ser Gly Tyr He Asp Lys Leu Ser Asp 150 155 160 165 • cgt ccg tcg att ggt aag gcg agt acg aat ccg tet gcg att gag ect 643 Arg Pro Ser He Gly Lys Wing Ser Thr Asn Pro Ser Wing He Glu Pro 170 175 180 ttg gcg ctg cat act ggc att att ttg ttg act gtt gcg gtt gcg tat 691 Leu Ala Leu His Thr Gly He He Leu Leu Thr Val Ala Wing Ala Tyr 185 190 195 tcc att aat cag tgg ttg ggt age atg ttc cca acc gtg cag att ccg 739 Ser He Asn Gln Trp Leu Gly Ser Met Phe Pro Thr Val Gln He Pro 200 205 210 ttg ttt gcg atg tea ttt gtg gtc ggc att gtg ggc atg gga att atg 787 Leu Phe Ala Met Ser Phe Val Val Gly He Val Gly Met Gly He Met 10 215 220 225 cgt ttg tag aag aag ect gag tat ttg gat cgc gac acc gtg aat tcc 835 Arg Leu Leu Lys Lys Pro Glu Tyr Leu Asp Arg Asp Thr Val Asn Ser 230 235 240 245 gtg tcg ggc gcg gcg acg gat tac etc att gcg ttt ggt att gcc tcg 883 Val Ser Gly Wing Wing Thr Asp Tyr Leu He Wing Phe Gly He Wing Ser 250 255 260 att gct ect gct gcg att gct gat tac tgg gtt ect ctt gtg gtg ctg 931 He Wing Pro Wing Wing He Wing Asp Tyr Trp Val Pro Leu Val Val Leu 265 270 275 ttt gtt ttg ggc acc ate aac tgt tgt ttc ttc ttt ttc tgg gtt gcg 979 Phe Val Leu Gly Thr He Asn Cys Cys Phe Phe Phe Phe Trp Val Wing 15 280 285 290 ect cgt ttc ttt ggc gag aag tgg ctg gag cgc gcg ate ttc ggt tgg 1027 Pro Arg Phe Phe Gly Glu Lys Trp Leu Glu Arg Wing He Phe Gly Trp 295 300 305 ggt tgg gct act gcc gcg gtt gct acc ggt ate gcg ttg ctg aag ate 1075 Gly Trp Wing Thr Wing Wing Val Wing Thr Gly He Wing Leu Leu Lys He 310 315 320 325 gtg gat ccg aag ttg aag tcg gga gcg ctt aat gag tac ggc gtg gct 1123 Val Asp Pro Lys Leu Lys Ser Gly Ala Leu Asn Glu Tyr Gly Val Wing • 330 335 340 tat ate ggt ttt gct cca ttt gaa ate ggc atg acc ate ate gcg ccg 1171 Tyr He Gly Phe Wing Pro Phe Glu He Gly Met Thr He He Wing Pro 20 345 350 355 ate gcg gtg etc gca ggc ttt acc atg ggg ttg ggt tgg gcg tcg ttg 1219 He Wing Val Leu Wing Gly Phe Thr Met Gly Leu Gly Trp Wing Ser Leu 360 365 370 att gtt gcg ate gtg att ttt ggc etc gcg tgg ggt ctg aag tgg ttg 1267 He Val Wing He Val He Phe Gly Leu Wing Trp Gly Leu Lys Trp Leu 375 380 385 ccg gag cgc gga cat gtc cgc ggc gag ggt aag ccg caa taaeiggttgg 1316 Pro Glu Arg Gly His Val Arg Gly Glu Gly Lys Pro Gln 390 395 400 aagcgccggg tet 1329 25 < 210 > 508 < 211 > 402 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 508 Met He Leu Gly Pro Lys Val Leu Gly Leu He Gly Trp Ser Asp His 1 5 10 15 Leu Ser Thr Tyr Thr Thr Val Leu He Wing He Val Phe Wing Ser Met 20 25 30 • Pro Tyr Ser Met Lys Phe Asp Arg Gly Val Arg Thr Gly Met Lys Thr 35 40 45 Met Trp Wing Tyr Ser Thr Wing Met Phe Val Gly Gln Trp Gly Leu Phe 50 55 60 He Leu Leu Gly Leu Phe Leu Phe Gln Pro Val Trp Gly Thr Asp Glu 65 70 75 80 Trp Phe Gly Met Met Leu Pro Val Gly Phe Val Gly Gly Phe Gly Thr 85 90 95 Wing Wing Val Gly Thr Wing Ala Leu Glu Ser Ser Gly Wing Glu Wing Wing 100 105 110 Met Ser Leu Gly Phe Thr Ser Wing Thr Val Gly Thr Phe Ala Ala He 10 115 120 125 Val Gly Gly He He Phe Thr Thr Trp Gly He Lys Lys Gly Lys Thr 130 135 140 Ala Ala Met Pro Ala Gln Leu Pro Trp Asp Leu Arg Ser Gly Tyr He • 145 150 155 160 Asp Lys Leu Being Asp Arg Pro Ser He Gly Lys Wing Being Thr Asn Pro 165 170 175 Being Wing He Glu Pro Leu Wing Leu His Thr Gly He He Leu Leu Thr 180 185 190 Val Wing Val Wing Tyr Being He Asn Gln Trp Leu Gly Being Met Phe Pro 195 200 205 Thr Val Gln He Pro Leu Phe Wing Met Ser Phe Val Val Gly He Val 15 210 215 220 Gly Met Gly He Met Arg Leu Leu Lys Pro Glu Tyr Leu Asp Arg 225 230 235 240 Asp Thr Val Asn Ser Val Ser Gly Ala Thr wing Asp Tyr Leu He Wing 245 250 255 Phe Gly He Wing Ser Wing Pro Wing Wing He Wing Asp Tyr Trp Val 260 265 270 Pro Leu Val Val Leu Phe Val Leu Gly Thr He Asn Cys Cys Phe Phe 275 280 285 • Phe Phe Trp Val Wing Pro Arg Phe Phe Gly Glu Lys Trp Leu Glu Arg 290 295 300 Wing He Phe Gly Trp Gly Trp Wing Thr Wing Wing Val Wing Thr Gly He 20 305 310 315 320 Wing Leu Leu Lys He Val Asp Pro Lys Leu Lys Ser Gly Ala Leu Asn 325 330 335 Glu Tyr Gly Val Wing Tyr He Gly Phe Wing Pro Phe Glu He Gly Met 340 345 350 Thr He He Wing Pro W He Wing Val Leu Wing Gly Phe Thr Met Gly Leu 355 360 365 Gly Trp Wing Leu He Val Wing He Val He Phe Gly Leu Wing Trp 370 375 380 Gly Leu Lys Trp Leu Pro Glu Arg Gly His Val Arg Gly Glu Gly Lys 385 390 395 400 Pro Gln 25 TO. % ? ? < 210 > 509 < 211 > 1776 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1753) < 223 > RXA02171 < 400 > 509 aaccacattc < gtca'ttactt acatetatgt ca1tgtttgcg aacaaga, act 'tggaigeeteg 60 tcaggctgct, attcigccaga aigatggaagg tt; aatcagat atg aat tcct att att 115 Met Asn Ser Thr He 1 5 etc ctt gca ca gc gac gtt tet gag ggc gtc ggt aat ccg att ctt 163 Leu Leu Ala Gln Asp Ala Val Ser Glu Gly Val Gly Asn Pro He Leu 10 15 20 aac ate agt gtc ttc gtc gtc ttc att att gtg acg atg acc gtg gtg 211 Asn He Ser Val Phe Val Val Phe He He Val Thr Met Thr Val Val 25 30 35 ctt cgc gtg ggc aag age acc gaa tcc acc gac ttc tac acc ggt 259 Leu Arg Val Gly Lys Ser Thr Ser Glu Ser Thr Asp Phe Tyr Thr Gly 40 45 ggt 50 ggt gct tcc tcc gga acc ggt cag aac ggt ctg gct ate gca ggt gac 307 Gly Wing Being Phe Be Gly Thr Gln Asn Gly Leu Wing He Wing Gly Asp 55 60 65 tac ctg tet gca gcg tcc ttc etc gga ate gtt ggt gca att tea etc 355 Tyr Leu Ser Ala Ala Ser Phe Leu Gly He Val Gly Ala He Ser Leu 70 75 80 85 aac ggt tac gac gga ttc ctt tac tcc ate ggc ttc ttc gtc gca tgg 403 Asn Gly Tyr Asp Gly Phe Leu Tyr Ser He Gly Phe Phe Val Wing Trp 90 95 100 ctt gtt gca ctg ctg etc gtg gca gag cca ctt cgt aac gtg ggc cgc 451 Leu Val Ala Leu Leu Leu Val Ala Glu Pro Leu Arg Asn Val Gly Arg 105 110 115 ttc acc atg gct gac gtg ctg tcc ttc cga ctg cgt cag aaa cca gtc 499 Phe Thr Met Wing Asp Val Leu Ser Phe Arg Leu Arg Gln Lys Pro Val 120 125 130 cgc gtc gct gcg gcc tgc ggt acc etc gcg gtt acc etc ttt tac ttg 547 Arg Val Wing Wing Wing Cys Gly Thr Leu Wing Val Thr Leu Phe Tyr Leu 135 140 145 ate gct cag atg gct ggt gca ggt tcg ctt gtg tcc gtt ctg ctg gac 595 I have Ala Gln Met Ala Gly Ala Gly Ser Leu Val Ser Val Leu Leu Asp 150 155 160 165 ate cae gag ttc aag tgg cag gca gtt gtt gtc ggt ate gtt ggc att 643 He His Glu Phe Lys Trp Gln Wing Val Val Val Gly He Val Gly He 170 175 180 gtc atg ate gcc tac gtt ctt ctt ggc ggt atg aag ggc acc ac ta ta 691 Val Met He Wing Tyr Val Leu Leu Gly Gly Met Lys Gly Thr Thr Tyr 185 190 195 gtt cag atg att aag gca gtt ctg ctg gtc ggt ggc gtt gcc att atg 739 Val Gln Met He Lys Wing Val Leu Leu Val Gly Gly Val Wing Met 200 205 210 acc gtt ctg acc ttc gtc aag gtg tet ggt ggc ctg acc acc ttt tta 787 Thr Val Leu Thr Phe Val Lys Val Ser Gly Gly Leu Thr Thu Leu Leu 215 220 225 aat gac gct gtt gag aag drops gcc gct tea gat tac gct gcc acc aag 835 Asn Asp Wing Val Glu Lys His Wing Ala Ser Asp Tyr Wing Ala Thr Lys 230 235 240 245 ggg tac gat cca g ect ggt cctg gag ect ggt ctg cag tac ggt gca 883 Gly Tyr Asp Pro Thr Gln He Leu Glu Pro Gly Leu Gln Tyr Gly Ala 250 255 260 act ctg acc act cag ctg gac ttc att tcc ttg gct etc gct ctg tgt 931 Thr Leu Thr Thr Gln Leu Asp Phe He Ser Leu Ala Leu Ala Leu Cys 265 270 275 • ctt gga acc gct ggt ctg cca falls gtt ctg atg cgc ttc tac acc gtt 979 Leu Gly Thr Ala Gly Leu Pro His Val Leu Met Arg Phe Tyr Thr Val 280 285 290 ect acc gcc aag gaa gca cgt aag tet gtg acc tgg gct ate gtc etc 1027 Pro Thr Ala Lys Glu Ala Arg Lys Ser Val Thr Trp Ala He Val Leu 295 300 305 att ggt gcg tcc tac ctg atg acc ctg gtc ctt ggt tac ggc gcg gcg 1075 He Gly Wing Phe Tyr Leu Met Thr Leu Val Leu Gly Tyr Gly Ala Wing 310 315 320 325 gca ctg gtc ggt cca gac cgc gtc att g cc gca cca ggt gct gct aat 1123 Wing Leu Val Gly Pro Asp Arg Val He Wing Wing Pro Gly Wing Wing Asn 10 330 335 340 gct gct ect ctg ctg gcc ttc gag ctt ggt ggt tcc ate ttc atg 1171 Ala Ala Ala Pro Leu Leu Ala Phe Glu Glu Leu Gly Gly Ser He Phe Met 345 345 355 • gcg ctg att tcc gca gtt gcg ttc gct acc gtt etc gcc gtg gtc gca 1219 Ala Leu He Ser Ala Val Ala Phe Ala Thr Val Leu Ala Val Val Ala Ala 365 365 370 ggt ctt gca att acc gca tcc gct gct gtt ggt falls gac ate tac aac 1267 Gly Leu Wing He Thr Wing Wing Wing Wing Val Gly His Asp He Tyr Asn 375 380 385 gct gtt tc cgc aac ggt cag tcc acc gaa gcg gag cag gtc cga gta 1315 Wing Val He Arg Asn Gly Gln Ser Thr Glu Wing Glu Gln Val Arg Val 15 390 395 400 405 tcc cgc ate acc gtt gtc gtc att ggc ctg att tcc att gtc ctg gga 1363 Ser Arg He Thr Val Val Val He Gly Leu He Ser He Val Leu Gly 410 415 420 att ctt gca atg acc cag aac gtt gcg ttttcc eettcc ggttgg ggcccc ccttgg ggcccc ttttcc 1411 He Leu Wing Met Thr Gln Asn Val Wing Phe Leu Val Wing Leu Wing Phe 425 430 435 gca gtt gca gca tcc gct aac ctg cca aacccc aattee ccttgg ttaacc ttcccc ccttgg ttaacc 1459 Ala Val Wing Wing Wing Asn Leu Pro Thr He Leu Tyr Ser Leu Tyr • 440 445 450 tgg aag aag ttc aac acc acc ggc gct gtg gcc gct ate tac acc ggt 1507 Trp Lys Lys Phe Asn Thr Thr Gly Wing Val Wing Wing He Tyr Thr Gly 20 455 460 465 etc tcc gcg ctg ctg ctg ctg ate ttc ctg tcc cca gca gtc tcc ggt 1555 Leu He Ser Ala Leu Leu Leu He Phe Leu Ser Pro Ala Val Ser Gly 470 475 480 485 aat gac age gca atg gtt cca ggt gca gac tgg gca ate ttc cca ctg 1603 Asn Asp Be Wing Met Val Pro Gly Wing Asp Trp Wing He Phe Pro Leu 490 495 500 aag aac cca ggc etc gtc tcc ate cca ctg gca ttc ate gct ggg tgg 1651 Lys Asn Pro Gly Leu Val Ser He Pro Leu Wing Phe He Wing Wing Gly Trp 505 510 515 ate ggc act ttg gtt ggc aag cca gac aac at gat gat ctt gct gcc 1699 He Gly Thr Leu Val Gly Lys Pro Asp Asn Met Asp Asp Leu Ala Wing 25 520 525 530 •• * "• * * gaa gaa atg aka etc acc GTT GGT CGT GGT GTT GTC AAG GAA GTT GCT 1747 Met Glu Glu Val Leu Thr Arg Ser Gly Gly Val Lys Val Glu Ala Val 535,540,545 gat falls taaatctagt ttctgaagtt att 1776 Asp His 550 < 210 > 510 < 211 > 551 • < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 510 Met Asn Ser Thr He Leu Leu Wing Gln Asp Wing Val Ser Glu Gly Val 1 5 10 15 Gly Asn Pro He Leu Asn He Ser Val Phe Val Val Phe He He Val 20 25 30 Thr Met Thr Val Val Leu Arg Val Gly Lys Being Thr Ser Glu Being Thr 35 40 45 Asp Phe Tyr Thr Gly Gly Wing Being Phe Being Gly Thr Gln Asn Gly Leu 10 50 55 60 Wing Wing Wing Gly Asp Tyr Leu Wing Wing Being Phe Leu Gly He Val 65 70 75 80 Gly Ala He Ser Leu Asn Gly Tyr Asp Gly Phe Leu Tyr Ser He Gly • 85 90 95 Phe Phe Val Wing Trp Leu Val Wing Leu Leu Leu Val Wing Glu Pro Leu 100 105 110 Arg Asn Val Gly Arg Phe Thr Met Wing Asp Val Leu Be Phe Arg Leu 115 120 125 Arg Gln Lys Pro Val Arg Val Wing Wing Cys Gly Thr Leu Wing Val 130 135 140 Thr Leu Phe Tyr Leu He Wing Gln Met Wing Gly Wing Gly Ser Leu Val 15 145 150 155 160 Ser Val Leu Leu Asp He His Glu Phe Lys Trp Gln Wing Val Val Val 165 170 175 Gly He Val Gly He Val Met He Wing Tyr Val Leu Leu Gly Gly Met 180 185 190 Lys Gly Thr Thr Tyr Val Gln Met He Lys Wing Val Leu Leu Val Gly 195 200 2 05 Gly Val Ala He Met Thr Val Leu Thr Phe Val Lys Val Ser Gly Gly 210 215 220 • Leu Thr Thr Leu Leu Asn Asp Ala Val Glu Lys His Ala Ala Ser Asp 225 230 235 240 Tyr Ala Ala Thr Lys Gly Tyr Asp Pro Thr Gln He Leu Glu Pro Gly 20245250255 Leu Gln Tyr Gly Ala Thr Leu Thr Thr Gln Leu Asp Phe He Ser Leu 260 265 270 Ala Leu Ala Leu Cys Leu Gly Thr Ala Gly Leu Pro His Val Leu Met 275 280 285 Arg Phe Tyr Thr Val Pro Thr Ala Lys Glu Ala Arg Lys Ser Val Thr 290 295 300 Trp Ala He Val Leu He Gly Ala Phe Tyr Leu Met Thr Leu Val Leu 305 310 315 320 Gly Tyr Gly Ala Ala Ala Leu Val Gly Pro Asp Arg Val He Ala Ala 325 330 335 Pro Gly Ala Ala Asn Ala Ala Ala Pro Leu Leu Ala Phe Glu Leu Gly 25 340 345 350 Gly Ser He Phe Met Wing Ala Leu He Wing Wing Val Wing Phe Wing Thr Val 355 360 365 Leu Wing Val Val Wing Gly Leu Wing He Thr Wing Wing Wing Wing Val Gly 370 375 380 His Asp He Tyr Asn Wing Val He Arg Asn Gly Gln Ser Thr Glu Wing 385 390 395 400 Glu Gln Val Arg Val Ser Arg He Thr Val Val Val He Gly Leu He 405 410 415 Ser He Val Leu Gly He Leu Ala Met Thr Gln Asn Val Ala Phe Leu • 420 425 430 Val Ala Leu Ala Phe Ala Val Ala Ala Ser Ala Asn Leu Pro Thr I 435,440,445 Leu Tyr Ser Leu Tyr Trp Lys Lys Phe Asn Thr Thr Gly Ala Val Ala 450,455,460 Ala I Tyr Thr Gly Leu He Ser Ala Leu Leu Leu He Phe Leu Ser 465 470 475 480 Pro Ala Val Ser Gly Asn Asp Ser Ala Met Val Pro Gly Ala Asp Trp 485 490 495 Ala He Phe Pro Leu Lys Asn Pro Gly Leu Val Ser He Pro Leu Ala 500 505 510 10 Phe He Ala Gly Trp He Gly Thr Leu Val Gly Lys Pro Asp Asn Met 515 520 525 Asp Asp Leu Ala Wing Glu Met Glu Val Arg Ser Leu Thr Gly Val Gly 530 535 540 Val Glu Lys Ala Val Asp His 545 550 < 210 > 511 < 211 > 1333 < 212 > DNA < 213 > Corynebacterium glutamicum 15 < 220 > < 221 > CDS < 222 > (101) .. (1333) < 223 > RXA00902 < 400 > 511 ttgttattgg 1tttgttcact ctrcatgcaat gtacgatcgg ttetaaegtc tacggcaatt 60 gacacgttaa 1tttaattcag gaaaggggtg gggagaattt atg tet agt ggt ttt 115 Met Ser Ser Gly Phe • 1 5 gaa tat gtt ca a cat ect cga cga gcc etc ect ccg ect ata ect gaa 163 Glu Tyr Val Gln His Pro Arg Arg Ala Leu Pro Pro Pro He Pro Glu 20 10 15 20 cgg aaa ggt ect gcc gca gca ttc ctg ccg gga act ttc cat ccc att 211 Arg Lys Gly Pro Wing Wing Wing Phe Leu Pro Gly Thr Phe His Pro He 25 30 35 aat cca aag aat att gca gcg age falls gat cag gtg ctt cta tet ggt 259 Asn Pro Lys Asn He Wing Wing His Asp Gln Val Leu Leu Ser Gly 40 45 50 tgg ggc aaa ttt gtg cgt tgg etc ttg gta ttg ttg tcc att ttg gtc 307 Trp Gly Lys Phe Val Arg Trp Leu Leu Val Leu Leu Ser He Leu Val 55 60 65 ate ate att ggc ate aac etc ate ttg gac ggt gtc tac gga ttt ggt 355 He He He He Gly He Asn Leu He Leu Asp Gly Val Tyr Gly Phe Gly 25 70 75 80 85 | ^^ _ jj ^ act ttt tea acc acc cag atc tac gtt gcg aaa gat cca etc att 403 Thr Phe Ser Thr Thr Gln Met Tyr Gln Val Wing Lys Asp Pro Leu He 90 95 100 ggt gtg ctg ate ggt ate ttg gct acg gcc ttg gtg ca tea tea acc 451 Gly Val Leu He Gly He Leu Wing Thr Wing Leu Val Gln Ser Ser Thr 105 110 115 acc ac acg ttg acg gtg act gca gtt ggt acg ggc att gtg tcg 499 Thr Thr Thr Thr Leu Thr Val Thr Wing Val Gly Thr Gly He Val Ser 120 125 130 • gtg ect gtg gcg att ccg ate att ctt ggc gca aat ate ggt acg acg 547 Val Pro Val Wing Pro He He Leu Gly Wing Asn He Gly Thr Thr 135 140 145 ate acc gcg atg etc gtt gcg ttt tet tat gtg ggt gaa cgc agg gag 595 He Thr Ala Met Leu Val Ala Phe Ser Tyr Val Gly Glu Arg Arg Glu 150 155 160 165 ttt aag cga gct ttt acg gtt gcc gcc atg cat gtg tgg ttt aac gtg 643 Phe Lys Arg Ala Phe Thr Val Ala Ala Met His Val Trp Phe Asn Val 170 175 180 etc gtc att ctt gtt cta ttt gtt gtg gaa ttg etc ttt cat cca tcc 691 Leu Val He Leu Val Leu Phe Val Val Glu Leu Leu Phe His Pro Phe 10 185 190 195 cgc here att agt ggt gcg ate gca acg gag ate here ctg here act ggt 739 Arg Thr He Ser Gly Wing He Wing Thr Glu He Thr Leu Thr Thr Gly 200 205 210 • ggc tet ttg ect acc agt ggt gtg atg acc aag att ttt gatccc cca 787 Gly Ser Leu Pro Thr Ser Gly Val Met Thr Lys He Phe Asp Pro Pro 215 220 225 Acc ata ctt ctg ggt atg aat ggt ctt ate ggt tcg ate ggc aat ect 835 Thr Gln Leu Leu Gly Met Asn Gly Leu He Gly Ser He Gly Asn Pro 230 235 240 245 agt att tcg gcg att gta tgt ctt gtg gtg ggggcc aacccc aatttt cctttt aatttt ccttgg 883 Ser He Ser Wing He Val Cys Leu Val Val Gly Thr He Leu He Leu 15 250 255 260 att tcg gtg cgt gc c atg agt tet cag ate ccggaa aacccc aatttt aaccgg ggccaa ggccgg 931 He Ser Val Arg Ala Met Being Ser Gln He Arg Thr He Thr Wing Ala 265 270 275 acc gta acc tea att atg gac aag gtg ate aat cca gag aac age ccc 979 Thr Val Thr Ser He Met Asp Lys Val He Asn Pro Glu Asn Ser Pro 2§0 285 290 aag gcg acg att ctt tcc aat ttc tgg age ttc att ctt gga gtt ttg 1027 Lys Wing Thr He Leu Ser Asn Phe Trp Ser Phe He Leu Gly Val Leu 295 300 305 ttc acg etc atg gtc act gcc tcg tea gtg acc gtg gct tcc atg cag 1075 Phe Thr Leu Met Val Thr Wing Being Ser Val Thr Val Wing Met Met Gln 20 310 315 320 325 cca gtg gct gcc tet ggt gtc gtt aag caa aag cca ttg ctg ggc gtc 1123 Pro Val Ala Ala Ser Gly Val Val Lys Gln Lys Pro Leu Leu Gly Val 330 335 340 att ttg ggt gcc aac gtg ggc acc acg gtg acc gca atg ttt gcct act 1171 He Leu Gly Wing Asn Val Gly Thr Thr Val Thr Wing Met Phe Wing Thr 345 350 355 ttc gcg att gtc age gat cag ggt gag ttc gct att cag gct gcg ttg 1219 Phe Wing He Val Valid Asp Gln Gly Glu Phe Wing He Gln Wing Wing Leu 360 365 370 tett falls etc att gtg aac ttc acc ggc gca tta ct gtg ctg tgt att 1267 He His Leu He Val Asn Phe Thr Gly Ala Leu Leu Val Leu Cys He 25 375 380 385 ccg cag ctt gcc aat gtg att att falls tcg gcc gag aaa act gcg aac 1315 Pro Gln Leu Ala Asn Val He He His Leu Ala Glu Lys Thr Ala Asn 390 395 400 405 etc. act gcc cgc agt tac 1333 Leu Thr Ala Arg Ser Tyr 410 < 210 > 512 < 211 > 411 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 512 Met Ser Ser Gly Phe Glu Tyr Val Gln His Pro Arg Arg Ala Leu Pro 1 5 10 15 Pro Pro He Pro Glu Arg Lys Gly Pro Wing Wing Wing Phe Leu Pro Gly 20 25 30 Thr Phe His Pro He Asn Pro Lys Asn He Wing Wing His Asp Gln 35 40 45 Val Leu Leu Ser Gly Trp Gly Lys Phe Val Arg Trp Leu Leu Val Leu 50 55 60 Leu Ser He Leu Val He He He Gly He Asn Leu He Leu Asp Gly 65 70 75 80 Val Tyr Gly Phe Gly Thr Phe Ser Thr Thr Gln Met Tyr Gln Val Wing 85 90 95 Lys Asp Pro Leu He Gly Val Leu He Gly He Leu Wing Thr Wing Leu 100 105 110 Val Gln Ser Ser Thr Thr Thr Thr Thr Leu Thr Val Thr Wing Val Gly 115 120 125 Thr Gly He Val Ser Val Pro Val Wing He Pro He He Leu Gly Wing 130 135 140 Asn He Gly Thr Thr He Thr Wing Met Leu Val Wing Phe Ser Tyr Val 145 150 155 160 Gly Glu Arg Arg Glu Phe Lys Arg Ala Phe Thr Val Wing Ala Met His 165 170 175 Val Trp Phe Asn Val Leu Val He Leu Val Leu Phe Val Val Glu Leu 180 185 190 Leu Phe His Pro Phe Arg Thr He Ser Gly Wing He Wing Thr Glu He 195 200 205 Thr Leu Thr Thr Gly Gly Ser Leu Pro Thr Ser Gly Val Met Thr Lys 210 215 220 He Phe Asp Pro Pro Thr Gln Leu Leu Gly Met Asn Gly Leu He Gly 225 230 235 240 Ser He Gly Asn Pro Ser He Wing Wing He Val Cys Leu Val Val Gly 245 250 255 Thr He Leu He Leu He Ser Val Arg Ala Met Ser Ser Gln He Arg 260 265 270 Thr He Thr Wing Wing Thr Val Thr Ser He Met Asp Lys Val He Asn 275 280 285 Pro Glu Asn Ser Pro Lys Wing Thr He Leu Ser Asn Phe Trp Ser Phe 290 295 300 He Leu Gly Val Leu Phe Thr Leu Met Val Thr Wing Ser Ser Val Thr 305 310 315 320 Val Wing Met Met Gln Pro Val Wing Wing Ser Gly Val Val Lys Gln Lys 325 330 335 Pro Leu Leu Gly Val He Leu Gly Wing Asn Val Gly Thr Thr Val Thr 340 345 350 Wing Met Phe Wing Thr Phe Wing He Val Ser Asp Gln Gly Glu Phe Wing 355 360 365 He Gln Ala Ala Leu He His Leu He Val Ace n Phe Thr Gly Wing Leu 370 375 380 Leu Val Leu Cys He Pro Gln Leu Wing Asn Val He He His Leu Wing 385 390 395 400 Glu Lys Thr Wing Asn Leu Thr Wing Arg Ser Tyr 405 410 • <; 210 > 513 < 211 > 1440 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1417) < 223 > RXA00941 < 400 > 513 agccggggtg < gccgtttgcg tgtactgggtt ttgcttatcg acgcceaictt ictgattttaa 60 10 aggieaaatat -tttgtgtcac a < gcgagtaat cttttcgggc atg aac cta acc cgg 115 Met Asn Leu Thr Arg 1 5 • aat gac agg etc gat cga ctg ccc gta act tcc aaa cat aaa aag att 163 Asn Asp Arg Leu Asp Arg Leu Pro Val Thr Ser Lys His Lys Lys He 10 15 20 ctt ggc ggc tea ggt ate ggc tgg gca ttg gat gcc atg gat gtc gga 211 Leu Gly Gly Be Gly He Gly Trp Wing Leu Asp Wing Met Asp Val Gly 25 30 35 ctg ate tet ttc gtc atg gct gcg ttg gcc act cat tgg ggc cta tcc 259 Leu He Ser Phe Val Met Ala Ala Ala Leu Ala Thr His Trp Gly Leu Ser 15 40 45 50 ect act gaa act tcc ctg etc gga tcc ate ggt ttc gtt ggc atg gcc 307 Pro Thr Glu Thr Ser Leu Leu Gly Ser He Gly Phe Val Gly Met Wing 55 60 65 ate ggc gct tcg ctg ggc ggt ttg ctg gcg gac aag ttg ggg cgt cga 355 He Gly Wing Being Leu Gly Gly Leu Leu Wing Asp Lys Leu Gly Arg Arg 70 75 80 85 ca gtt ttt gcg ttg tet ttg cta gtt tat ggc gtt gcc act ggc gcg 403 Gln Val Phe Wing Leu Ser Leu Leu Val Tyr Gly Val Wing Thr Gly Wing • 90 95 100 tcg gcg ctt tea gtg tcg ctg gca atg ttg atg gcg ctg cgc ttc gtc 451 Be Wing Leu Be Val Be Leu Wing Met Leu Met Wing Wing Leu Arg Phe Val 20 105 110 115 gtt gtt ctt ggc ctg ggc gct gaa etc ccc gtt gca tcc act ctg att 499 Val Gly Leu Gly Leu Gly Wing Glu Leu Pro Val Wing Being Thr Leu He 120 125 130 tcc gag ttt tet cca cga aaa gtt cgt ggc cgc atg gtc gtt ate ctg 547 Ser Glu Phe Ser Pro Arg Lys Val Arg Gly Arg Met Val Val He Leu 135 140 145 gag gcg ttt tgg gcg ctg ggc tgg ate atg gct gca ate gtc gga acc 595 Glu Wing Phe Trp Wing Leu Gly Trp He Met Wing Wing He Val Gly Thr 150 155 160 165 ttt gtc gtg gca gga tcc gat aat ggt tgg cgt tgg gcg tta gct ctt 643 Phe Val Val Wing Gly Ser Asp Asn Gly Trp Arg Trp Wing Leu Wing Leu 25 170 175 180 ggc tgt gtc ect gca att tac gcg gtg tat gtc cgt etc gga ctt cca 691 Gly Cys Val Pro Ala He Tyr Ala Val Tyr Val Arg Leu Gly Leu Pro 185 190 195 gaa tea gta cgt ttc ctg gag aag aaa ggc cgg falls gac gaa gca gaa 739 Glu Ser Val Arg Phe Leu Glu Lys Lys Gly Arg His Asp Glu Wing Glu 200 205 210 gcc ate gtt gtt tcc ttc gaa gaa gct gcc gct gcc gaa ggt aaa gct 787 Wing He Val Val Ser Phe Glu Glu Wing Wing Wing Wing Glu Gly Lys Wing 215 220 225 • gcc gat gcc acc gct action gtg gtt cat gac aac gct gcc gag ggt tcc 835 Wing Asp Wing Thr Thr Ala Val Val As Asn Ala Ala Ala Glu Gly Ser 230 235 240 245 gta tcc ate tgg tea gct gct tcg cgc aag cgc acc gtc gcg ctg tgg Val Ser He Trp Ser Ala Ala Leu Arg Lys Arg Thr Val Ala Leu Trp 250 255 260 ate gtg tgg ttc tgc ate aac ttg tcc tac tac gc gcc ttc att tgg 931 He Val Trp Phe Cys He Asn Leu Ser Tyr Tyr Gly Wing Phe He Trp 265 270 275 att cca tcg ctg ctg gtt gcc gac ggt ttc acc etc gtg aag tet ttc 979 He Pro Ser Leu Leu Val Wing Asp Gly Phe Thr Leu Val Lys Ser Phe 10 280 285 290 cat tcc act ctg ate ate ctg gct ca g cc gcc tat gcg gtt 1027 Gln Phe Thr Leu He He Thr Leu Wing Gln Leu Pro Gly Tyr Wing Val 295 300 305 • gca gcg tgg ttg att gaa aag tgg ggc cgc cgc age here ttg gcc acg 1075 Wing Wing Trp Leu He Glu Lys Trp Gly Arg Arg Ser Thr Leu Wing Thr 310 315 320 325 ttc ctg gtt ggt tet gct ate tet gca gcg etc tac ggc ttg gca aat 1123 Phe Leu Val Gly Ser Wing Be Wing Wing Leu Tyr Gly Leu Wing Asn 330 335 340 gtg gag tgg cag ate ctg gtc gca ggt tgt tta cta tcc ttc ttc aac 1171 Val Glu Trp Gln He Leu Val Wing Gly Cys Leu Leu Ser Phe Phe Asn 15 345 350 355 ctg ggc gca tgg ggc gca ctg tat gcc att ggg ccg gag ctt tat ccc 1219 Leu Gly Wing Trp Gly Wing Leu Tyr Wing He Gly Pro Glu Leu Tyr Pro 360 365 370 act aat gtc cgt gga act gga acg ggt gct gcc gcg gga ttc ggg cgc 1267 Thr Asn Val Arg Gly Thr Gly Thr Gly Wing Wing Wing Gly Phe Gly Arg 375 380 385 att gct tcc ate ate gct ccg etc att gtt ccg cca gtg att gct ttt 1315 He Wing Be He He Wing Pro Leu He Val Pro Pro Val He Wing Phe • 390 395 400 405 ggt gga cca att gct ttg ttc gct etc ttt gcc acc gcg ttt gcg ate 1363 Gly Gly Pro He Wing Leu Phe Wing Leu Phe Wing Thr Wing Phe Wing He 20 410 415 420 gca gcg att gcg gcg ttt acg ctg ect gag cag aag ggt aag tet etc 1411 Wing Wing Wing Wing Phe Thr Leu Pro Glu Gln Lys Gly Lys Ser Leu 425 430 435 gct gat tagtgagatc cttccaccag ttt 1440 Wing Asp < 210 > 514 < 211 > 439 < 212 > PRT < 213 > Corynebacterium glutamicum 25 < 400 > 514 Met Asn Leu Thr Arg Asn Asp Arg Leu Asp Arg Leu Pro Val Thr Ser 1 5 10 15 Lys His Lys Lys He Leu Gly Gly Ser Gly He Gly Trp Wing Leu Asp 20 25 30 Wing Met Asp Val Gly Leu He Ser Phe Val Met Ala Ala Leu Ala Thr 35 40 45 His Trp Gly Leu Ser Pro Thr Glu Thr Ser Leu Leu Gly Ser He Gly 50 55 60 • Phe Val Gly Met Wing He Gly Wing Ser Leu Gly Gly Leu Leu Wing Asp 65 70 75 80 Lys Leu Gly Arg Arg Gln Val Phe Wing Leu Ser Leu Leu Val Tyr Gly 85 90 95 Val Wing Thr Gly Wing Being Wing Leu Ser Val Being Leu Wing Met Leu Met 100 105 110 Wing Leu Arg Phe Val Val Gly Leu Gly Leu Gly Wing Glu Leu Pro Val 115 120 125 Wing Ser Thr Leu He Ser Glu Phe Ser Pro Arg Lys Val Arg Gly Arg 130 135 140 Met Val Val He Leu Glu Wing Phe Trp Wing Leu Gly Trp He Met Wing 10 145 150 155 160 Wing He Val Gly Thr Phe Val Val Wing Gly Ser Asp Asn Gly Trp Arg 165 170 175 Trp Ala Leu Ala Leu Gly Cys Val Pro Ala He Tyr Ala Val Tyr Val • 180 185 190 Arg Leu Gly Leu Pro Glu Ser Val Arg Phe Leu Glu Lys Lys Gly Arg 195 200 205 His Asp Glu Wing Glu Wing He Val Val Ser Phe Glu Glu Wing Wing 210 215 220 Wing Glu Gly Lys Wing Wing Asp Wing Thr Thr Wing Val Val His Asp Asn 225 230 235 240 Wing Wing Glu Gly Ser Val Ser He Trp Be Wing Wing Leu Arg Lys Arg 15 245 250 255 Thr Val Wing Leu Trp He Val Trp Phe Cys He Asn Leu Ser Tyr Tyr 260 265 270 Gly Wing Phe He Trp He Pro Ser Leu Leu Val Wing Asp Gly Phe Thr 275 280 285 Leu Val Lys Ser Phe Gln Phe Thr Leu He He Thr Leu Wing Gln Leu 290 295 300 Pro Gly Tyr Wing Val Wing Wing Trp Leu He Glu Lys Trp Gly Arg Arg 305 310 315 320 • Be Thr Leu Wing Thr Phe Leu Val Gly Wing Be Ala Ala Leu 325 330 335 Tyr Gly Leu Ala Asn Val Glu Trp Gln He Leu Val Ala Gly Cys Leu 20 340 345 350 Leu Ser Phe Phe Asn Leu Gly Wing Trp Gly Wing Leu Tyr Wing He Gly 355 360 365 Pro Glu Leu Tyr Pro Thr Asn Val Arg Gly Thr Gly Thr Gly Wing Wing 370 375 380 Wing Gly Phe Gly Arg He Wing Being He Wing Pro Pro Leu He Val Pro 385 390 395 400 Pro Val He Wing Phe Gly Pro Gly Pro Wing Leu Phe Al to Leu Phe Wing 405 410 415 Thr Wing Phe Wing Wing Wing Wing Wing Wing Phe Thr Leu Pro Glu Gln 420 425 430 Lys Gly Lys Ser Leu Wing Asp 25 435 ? ^ ^ üg ^^ *** »-» ¿~ * ^ < 210 > 515 < 211 > 1704 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1681) • < 223 > RXN00449 < 400 > 515 tcgttggctt, acatiggtcat t > gatgaccgg getgaaggg tgagaaaatc, catcccttct 60 ttaagcaagg gagtgaatta cagaaaagga ttgttcagca atg age here ect gac 115 Met Ser Thr Pro Asp 1 5 att aaa gaa ggc tcg gca gaa tea ccg ggc gaa gta atg gtc gtt gga 163 He Lys Glu Gly Ser Ala Glu Ser Pro Gly Glu Val Met Val Val Gly 10 15 20 gac agg cga gag tgg cgt cga caga gca acc ggc ate att gcc ggc etc 211 10 Asp Arg Arg Glu Trp Arg Arg Gln Wing Thr Gly He He Wing Gly Leu 25 30 35 gtc tta gcc gcc ctg gtc tat ctt etc ttc ccc tcg aac tcc gtg gaa 259 Val Leu Ala Ala Leu Val Tyr Leu Leu Phe Pro Ser Asn Ser Val Glu 40 45 • 50 acc gtc atg caa tcc agt ggc gtc gat cca gaa act gaa tac acc aac 307 Thr Val Met Gln Ser Ser Gly Val Asp Pro Glu Thr Glu Tyr Thr Asn 55 60 65 aac gcg atg cgt ctt act gct gca gtc here ate ttg atg gca gtg tgg 355 Asn Ala Met Arg Leu Thr Ala Ala Val Thr He Leu Met Ala Val Trp 70 75 80 85 tgg atg here gaa gca ate cca cta gca gca acc gca ctt ate ccg ttg 403 15 Trp Met Thr Glu Ala He Pro Leu Ala Ala Thr Ala Leu He Pro Leu 90 95 100 gtt gt gt tct gct gtg cag gtt gtg gac ttt ggg aag gca here gct 451 Val Wing Phe Pro Wing Phe Gln Val Val Asp Phe Gly Lys Ala Thr Wing 105 110 115 ccg tat gcc aac ect acg age ttc etc ttc ttg ggc ggc ttt ctt atg 499 Pro Tyr Wing Asn Pro Thr Ser Phe Leu Phe Leu Gly Gly Phe Leu Met 120 125 130 gca ctt ggc ctg cag aaa tgg aac cta drops cg cgt atg gct cta gcg 547 • Wing Leu Gly Leu Gln Lys Trp Asn Leu His Arg Arg Met Wing Leu Wing 135 140 145 gtc gtg cta gct gtt ggt act aag cca aag caa ttg gtc ttg ggt ttt 595 20 Val Val Leu Wing Val Gly Thr Lys Pro Lys Gln Leu Val Leu Gly Phe 150 155 160 165 atg gtg gca act gga ttt ttg tcc atg tgg gtg tet aac act gca acg 643 Met Val Wing Thr Gly Phe Leu Ser Met Trp Val Ser Asn Thr Wing Thr 170 175 180 gcc gtg gtt atg tta ccg ate ggt atg tcg gta ctg gca ctg acc gct 691 Wing Val Val Met Leu Pro He Gly Met Ser Val Leu Ala Leu Thr Wing 185 190 195 gag act gtg ggc gga atg aaa aac aa aa aa aa aa aa aa aa aa aa aa aa aa aa aa aa aa aa aa aa Lys Phe Wing Thr Gly Leu 200 205 210 atg ctg tcc att gct tat tet gct tcc ate ggt tea etc ggc acc tta 787 25 Met Leu Ser He Ala Tyr Ser Ala Ser He Gly Ser Leu Gly Thr Leu -, i. », 215 220 225 att ggc acg cca ccc aat gcc ttg ctt gct gcg tat atg tet gaa tcg 835 He Gly Thr Pro Pro Asn Ala Leu Leu Ala Wing Tyr Met Ser Glu Ser 230 235 240 245 cat gat ate falls gga gt ttt gt cag tgg atg att ctt ggt gta cca 883 His Asp He His He Gly Phe Gly Gln Trp Met He Leu Gly Val Pro 250 255 260 att gct gtc gtc ttc acc ate ate gcg tgg ctt gtg ttg acc acc gtg 931 He Ala Val Val Phe Thr He He Wing Trp Leu Val Leu Thr Thr Val • 265 270 275 ttc aag cca gaa atg aaa gaa ate ect ggc gga cgt gaa ctg ate aaa 979 Phe Lys Pro Glu Met Lys Glu He Pro Gly Gly Arg Glu Leu He Lys 280 285 290 cgt gaa ate gct gaa atg ggg ccg tgg act gca ect cag gtc here gtg 1027 Arg Glu He Wing Glu Met Gly Pro Trp Thr Wing Pro Gln Val Thr Val 295 300 305 ggt gtt att ttt gcg gca gct gca ctg gct tgg gtc ttc att cca tta 1075 Gly Val He Phe Wing Wing Wing Wing Leu Wing Trp Val Phe He Pro Leu 310 315 320 325 act cta gat tgg acc ggt tcc cag etc tet ate aat gac tcc etc att 1123 10 Thr Leu Asp Trp Thr Gly Ser Gln Leu Ser He Asn Asp Ser Leu He 330 335 340 ggc ate gct gcc ggc ctg ctg atg ttt ate gtt ccc gct aac ttt aaa 1171 Gly He Ala Wing Gly Leu Leu Met Phe He Val Pro Wing Asn Phe Lys • 345 350 355 acc ggc gaa cgc att ctt gat tgg cgt act gca ggc gaa ctt cca tgg 1219 Thr Gly Glu Arg He Leu Asp Trp Arg Thr Wing Gly Glu Leu Pro Trp 360 365 370 gat gtt etc ttg ctt ttt ggt ggc ggg ctt tea ctt tet gcg atg ttt 1267 Asp Val Leu Leu Leu Phe Gly Gly Leu Ser Leu Ser Wing Met Phe 375 380 385 acc agement acg gga ctt tcc cta tgg ate ggt gaa cta gct aag gga ctt 1315 15 Thr Ser Thr Gly Leu Ser Leu Trp He Gly Glu Leu Wing Lys Gly Leu 390 395 400 405 gat gcc ctt cca ct cc cc tc ct ctg gtc 1363 Asp Ala Leu Pro He Phe He Leu He Phe Wing Wing Val Leu Val 410 415 420 ttc ttc ctg acc gag ttc acc tcc aac ac g ac gcg gca acc ttc 1411 Leu Phe Leu Thr Glu Phe Thr Ser Asn Thr Wing Thr Wing Wing Thr Phe 425 430 435 ctg cca ate atg ggt ggc gtc gcc gta ggt ate gga gt ctg gca ggt 1459 Leu Pro Met Gly Gly Val Val Gly Wing Gly Leu Thr Wing Gly 440 445 450 ggc gag cag aat gtt ctg ctg ctg ctg acc ate cca gtc gca ctg tcc gca 1507 20 Gly Glu Gln Asn Val Leu Leu Leu Thr He Pro Val Ala Leu Ser Wing 455 460 465 acc tgt gcg ttc atg ctt cca gtg gca acg ect cca aac gcg att gca 1555 Thr Cys Wing Phe Met Leu Pro Val Wing Thr Pro Pro Asn Wing He Wing 470 475 480 48-5 ttc ggc tcc ggc tac att aag ate ggc gaa atg gtc aag ggt ggt ctg 1603 Phe Gly Ser Gly Tyr He Lys He Gly Glu Met Val Lys Gly Gly Leu 490 495 500 tgg ctg aac ate ate gca gtc ate etc att acg att ttc acc tac ttc 1651 Trp Leu Asn He He Wing Val He Leu He Thr He Phe Thr Tyr Phe 505 510 515 gta gcg ate cca etc ttt ggc ate atg ctt taaelagtt: aa caggcccgca 1701 25 Val Ala He Pro Leu Phe Gly He Met Leu 520 525 gtc 1704 < 210 > 516 < 211 > 527 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 516 Met Ser Thr Pro Asp He Lys Glu Gly Ser Wing Glu Ser Pro Gly Glu 1 5 10 15 Val Met Val Val Gly Asp Arg Arg Glu Trp Arg Arg Gln Wing Thr Gly 20 25 30 He He Wing Wing Gly Leu Val Leu Wing Ala Leu Val Tyr Leu Leu Phe Pro 35 40 45 Ser Asn Ser Val Glu Thr Val Met Gln Ser Ser Gly Val Asp Pro Glu 50 55 60 Thr Glu Tyr Thr Asn Asn Wing Met Arg Leu Thr Wing Wing Val Thr He 65 70 75 80 Leu Met Wing Val Trp Trp Met Thr Glu Wing He Pro Leu Wing Ala Thr 10 85 90 95 Wing Leu He Pro Wing Leu Val Wing Phe Pro Wing Phe Gln Val Val Asp Phe 100 105 110 Gly Lys Wing Thr Wing Pro Tyr Wing Asn Pro Thr Ser Phe Leu Phe Leu • 115 120 125 Gly Gly Phe Leu Met Wing Leu Gly Leu Gln Lys Trp Asn Leu His Arg 130 135 140 Arg Met Ala Leu Ala Val Val Leu Ala Val Gly Thr Lys Pro Lys Gln 145 150 155 160 Leu Val Leu Gly Phe Met Val Wing Thr Gly Phe Leu Ser Met Trp Val 165 170 175 Ser Asn Thr Ala Thr Ala Val Val Met Leu Pro He Gly Met Ser Val 15 180 185 190 Leu Ala Leu Thr Ala Glu Thr Val Gly Gly Met Lys Asn Gln Lys Lys 1 95 200 205 Phe Ala Thr Gly Leu Met Leu Ser He Ala Tyr Ser Ala Ser He Gly 210 215 220 Ser Leu Gly Thr Leu He Gly Thr Pro Pro Asn Ala Leu Leu Ala Ala 225 230 235 240 Tyr Met Ser Glu Ser His Asp He His He Gly Phe Gly Gln Trp Met 245 250 255 • He Leu Gly Val Pro He Wing Val Val Phe Thr He He Wing Trp Leu 260 265 270 Val Leu Thr Thr Val Phe Lys Pro Glu Met Lys Glu He Pro Gly Gly 20 275 280 285 Arg Glu Leu He Lys Arg Glu He Wing Glu Met Gly Pro Trp Thr Wing 290 295 300 Pro Gln Val Thr Val Gly Val He Phe Wing Wing Wing Wing Leu Wing Trp 305 310 315 320 Val Phe He Pro Leu Thr Leu Asp Trp Thr Gly Ser Gln Leu Ser He 325 330 335 Asn Asp Ser Leu He Gly He Ala Wing Gly Leu Leu Met Phe He Val 340 345 350 Pro Wing Asn Phe Lys Thr Gly Glu Arg He Leu Asp Trp Arg Thr Wing 355 360 365 Gly Glu Leu Pro Trp Asp Val Leu Leu Leu Phe Gly Gly Gly Leu Ser 25 370 375 380 Leu Ser Wing Met Phe Thr Ser Thr Gly Leu Ser Leu Trp He Gly Glu 385 390 395 400 Leu Wing Lys Gly Leu Asp Wing Leu Pro He Phe He Leu He Phe Wing 405 410 415 He Wing Val Leu Val Leu Phe Leu Thr Glu Phe Thr Ser Asn Thr Wing 420 425 430 Thr Wing Wing Thr Phe Leu Pro He Met Gly Gly Val Wing Val Gly He 435 440 445 Gly Leu Thr Wing Gly Gly Glu Gln Asn Val Leu Leu Thr He Pro Le 450 450 460 Val Ala Leu Ser Wing Thr Cys Wing Phe Met Leu Pro Val Wing Thr Pro 465 470 475 480 Pro Asn Wing He Wing Phe Gly Ser Gly Tyr He Lys He Gly Glu Met 485 490 495 Val Lys Gly Gly Leu Trp Leu Asn He He Wing Val He Leu He Thr 500 505 510 He Phe Thr Tyr Phe Val Wing Pro Pro Leu Phe Gly He Met Leu 515 520 525 <; 210 > 517 10 < 211 > 1028 < 212 > DNA < 213 > Corynebacterium glutamicum • < 220 > < 221 > CDS < 222 > (1) .. (1005) < 223 > FRXA00449 < 400 > 517 ctg gca ctg acc gct gag act ggg ggc gga atg aaa aac caa aag aaaa 48 Leu Ala Leu Thr Ala Glu Thr Val Gly Gly Met Lys Asn Gln Lys Lys 15 1 5 10 15 ttc gcc act gga etc atg ctg tcc att gct tat tet gct tcc ate ggt 96 Phe Wing Thr Gly Leu Met Leu Ser Wing Tyr Ser Wing Being He Gly 20 25 30 tea etc ggc acc tta att ggc acg cca ccc aat gcc ttg ctt gct gcg 144 Ser Leu Gly Thr Leu He Gly Thr Pro Pro Asn Ala Leu Leu Ala Ala 35 40 45 tat atg tet gaa tcg cat gat ate fall gga ttt ggt cag tgg atg 192 Tyr Met Ser Glu Ser His Asp He His Gly Ghe Phe Gln Trp Met • 50 55 60 att ctt ggt gta cca att gct gtc gtc ttc acc ate ate gcg tgg ctt 240 He Leu Gly Val Pro He Wing Val Val Phe Thr He He Wing Trp Leu 20 65 70 75 80 gtg ttg acc acc gtg ttc aag cca gaa atg aaa gaa ate ect ggc gga 288 Val Leu Thr Thr Val Phe Lys Pro Glu Met Lys Glu He Pro Gly Gly 85 90 95 cgt gaa ctg ate aaa cgt gaa ate gct gaa atg ggg ccg tgg act gca 336 Arg Glu Leu He Lys Arg Glu He Ala Glu Met Gly Pro Trp Thr A the 100 105 110 ect cag gtc here gtg ggt gtt att ttt gcg gca gct gca ctg gct tgg 384 Pro Gln Val Thr Val Gly Val He Phe Wing Wing Wing Wing Leu Wing Trp 115 120 125 gtc ttc att cca tta act cta gat tgg acc ggt tcc cag etc tet ate 432 Val Phe He Pro Leu Thr Leu Asp Trp Thr Gly Ser Gln Leu Ser He 25 130 135 140 aat gac tcc etc att ggc ate gct gcc ggc ctg ctg atg ttt ate gtt 480 Asn Asp Being Leu He Gly He Wing Wing Gly Leu Leu Met Phe He Val 145 150 155 160 ccc gct aac ttt aaa ggc acc ggc cgc att ctt gat tgg cgt act gca 528 Pro Wing Asn Phe Lys Thr Gly Glu Arg He Leu Asp Trp Arg Thr Wing 165 170 175 ggc gaa ctt cca tgg gat gtt etc ttg ctt ttt ggt ggc ggg ctt tea 576 Gly Glu Leu Pro Trp Asp Val Leu Leu Leu Phe Gly Gly Gly Leu Ser 180 185 190 • ctt tet gcg atg ttt acc age acg gga ctt tcc cta tgg ate ggt gaa 624 Leu Ser Wing Met Phe Thr Ser Thr Gly Leu Ser Leu Trp He Gly Glu 195 200 205 cta gct aag gga ctt gat gcc ctt cca cc tc tc ct att tcc gcc 672 Leu Wing Lys Gly Leu Asp Wing Leu Pro He Phe He Leu He Phe Wing 210 215 220 att gct gtc ctg gtg ttg ttc ctg ctg acc gag ttc acc tcc aac acca gca 720 He Wing Val Leu Val Leu Phe Leu Thr Glu Phe Thr Ser Asn Thr Wing 225 230 235 240 here gcg gca acc ttc ctg cca ate atg ggt ggc gtc gcc gta ggt ate 768 Thr Ala Ala Thr Phe Leu Pro He Met Gly Gly Va l Wing Val Gly He 10 245 250 255 gga ctg acc gca ggt ggc gag cag aat gtt ctg ctg ctg acc ate cca 816 Gly Leu Thr Wing Gly Gly Glu Gln Asn Val Leu Leu Leu Thr He Pro 260 265 270 • gtc gca ctg tcc gca acc tgt gcg ttc atg ctt cca gtg gca acg ect 864 Val Ala Leu Ser Wing Thr Cys Wing Phe Met Leu Pro Val Wing Thr Pro 275 280 285 cca aac gcg att gca ttc ggc tcc ggc tac att aag ate ggc gaa atg 912 Pro Asn Ala He Wing Phe Gly Ser Gly Tyr He Lys He Gly Glu Met 290 295 300 gtc aag ggt ggt ctg tgg ctg aac ate ate gca gtc ate etc att acg 960 Val Lys Gly Gly Leu Trp Leu Asn He He Wing Val He Leu He Thr 305 310 15 315 320 att ttc acc tac ttc gta gcg ate cca etc ttt ggc ate atg ctt 1005 He Phe Thr Tyr Phe Val Wing Pro Pro Leu Phe Gly He Met Leu 325 330 335 taaaagttaa caggcccgca gt: c 1028 < 210 > 518 < 211 > 335 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 518 20 Leu Ala Leu Thr Ala Glu Thr Val Gly Gly Met Lys Asn Gln Lys Lys 1 5 10 15 Phe Ala Thr Gly Leu Met Leu Ser He Ala Tyr Ser Ala Ser He Gly 20 25 30 Ser Leu Gly Thr Leu He Gly Thr Pro Pro Asn Ala Leu Leu Ala Ala 35 40 45 Tyr Met Ser Glu Ser His Asp He His He Gly Phe Gly Gln Trp Met 50 55 60 He Leu Gly Val Pro He Wing Val Val Phe Thr He He Wing Trp Leu 65 70 75 80 Val Leu Thr Thr Val Phe Lys Pro Glu Met Lys Glu Pro Pro Gly Gly 85 90 95 25 Arg Glu Leu He Lys Arg Glu He Wing Glu Met Gly Pro Trp Thr Wing ^. & *? LJ 100 105 110 Pro Gln Val Thr Val Gly Val He Phe Ala Ala Ala Ala Leu Ala Trp 115 120 125 Val Phe He Pro Leu Thr Leu Asp Trp Thr Gly Ser Gln Leu Ser He 130 135 140 Asn Asp Ser Leu He Gly He Wing Wing Gly Leu Leu Met Phe He Val 145 150 155 160 Pro Wing Asn Phe Lys Thr Gly Glu Arg He Leu Asp Trp Arg Thr Wing 165 170 175 Gly Glu Leu Pro Trp Asp Val Leu Leu Leu Phe Gly Gly Gly Leu Ser 180 185 190 Leu Ser Wing Met Phe Thr Ser Thr Gly Leu Ser Leu Trp He Gly Glu 195 200 205 Leu Ala Lys Gly Leu Asp Ala Leu Pro He Phe He Leu He Phe Wing 210 215 220 He Wing Val Leu Val Leu Phe Leu Thr Glu Phe Thr Ser Asn Thr Wing 225 230 235 240 Thr Wing Wing Thr Phe Leu Pro Met Gly Gly Val Wing Val Gly He 245 250 255 Gly Leu Thr Wing Gly Gly Glu Gln Asn Val Leu Leu Leu Thr He Pro 10 260 265 270 Val Ala Leu Be Ala Thr Cys Ala Phe Met Leu Pro Val Ala Thr Pro 275 280 285 Pro Asn Ala He Ala Phe Gly Ser Gly Tyr He Lys He Gly Glu Met • 290 295 300 Val Lys Gly Gly Leu Trp Leu Asn He He Wing Val He Leu He Thr 305 310 315 320 He Phe Thr Tyr Phe Val Wing Pro Pro Leu Phe Gly He Met Leu 325 330 335 < 210 > 519 < 211 > 448 15 < 212 > DNA < 213 > Corynebact: erium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (448) < 223 > FRXA01755 < 400 > 519 • tcgttggctt; acatggtcat tgatgaccgg getgaatatg tgagaaaatc t; atcccttct 60 ttaagcaagg cgagtgaatta cagaaaagga ttgttcagca atg age here ect gac 115 Met Ser Thr Pro Asp 20 1 5 att aaa gaa ggc tcg gca gaa tea ccg ggc gaa gta atg gtc gtt gga 163 He Lys Glu Gly Be Wing Glu Ser Pro Gly Glu Val Met Val Val Gly 10 15 20 gac agg cga gag tgg cgt cga caga gca acc ggc ate att gcc ggc etc 211 Asp Arg Arg Glu Trp Arg Arg Gln Wing Thr Gly He He Wing Gly Leu 25 30 35 gtc tta gcc gcc ctg gtc tat ctt etc ttc ccc tcg aac tcc gtg gaa 259 Val Leu Ala Ala Leu Val Tyr Leu Leu Phe Pro Ser Asn Ser Val Glu 40 45 50 acc gtc at g cac tcc agt ggc gtc gat cca gaa act gaa tac acc aac 307 Thr Val Met Gln Ser Ser Gly Val Asp Pro Glu Thr Glu Tyr Thr Asn 25 55 60 65 , ^ - ji ifeJ aac gcg atg cgt ctt act gct gca gtc here ate ttg atg gca gtg tgg 355 Asn Wing Met Arg Leu Thr Wing Wing Val Thr He Leu Met Wing Val Trp 70 75 80 85 tgg atg here gaa gca ate cca cta gca gca acc gca ctc ctc gt tcg 403 Trp Met Thr Glu Wing Pro Pro Leu Wing Wing Thr Wing Leu Pro Leu 90 95 100 gtt gt gt tcc ect gct ttc cag gtt gtg gac ttt ggg aag gca gca 448 Val Wing Phe Pro Wing Phe Gln Val Val Asp Phe Gly Lys Ala Ala 5 105 110 115 < 210 > 520 < 211 > 116 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 520 Met Ser Thr Pro Asp He Lys Glu Gly Ser Wing Glu Ser Pro Gly Glu 1 5 10 15 Val Met Val Val Gly Asp Arg Arg Glu Trp Arg Arg Gln Wing Thr Gly 20 25 30 JQ He He Wing Wing Gly Leu Val Leu Wing Wing Leu Val Tyr Leu Leu Phe Pro 35 40 45 Ser Asn Ser Val Glu Thr Val Met Gln Ser Ser Gly Val Asp Pro Glu 50 55 60 • Thr Glu Tyr Thr Asn Asn Wing Met Arg Leu Thr Wing Wing Val Thr He 65 70 75 80 Leu Met Wing Val Trp Trp Met Thr Glu Wing He Pro Leu Wing Wing Thr 85 90 95 Wing Leu He Pro Leu Val Wing Phe Pro Wing Phe Gln Val Val Asp Phe 100 105 110 Gly Lys Ala Wing 115 15 < 210 > 521 < 211 > 912 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (889) • < 223 > RXA00269 < 400 > 521 2Q tgcgatcttg gtggttgteg ccatgctgct gccgaggtgg cgtgegaagt tctccaaggc 60 accgaagcct aagcaaccag tagcagtgga ggcttaagac atg tta tcc ate aac 115 Met Leu Ser He Asn 1 5 gga att tet aag acg ttc ttc ccc ggc act gtg aat gag cgc cgc gcg 163 Gly He Ser Lys Thr Phe Phe Pro Gly Thr Val Asn Glu Arg Arg Wing 10 15 20 ttg cag cag etc aaa etc gat atg gct gag ggc gat ttt gtc acc gtc 211 Leu Gln Gln Leu Lys Leu Asp Met Wing Glu Gly Asp Phe Val Thr Val 25 30 35 ate ggt tet aac ggt gcg ggt aaa tcc acg ctg etc aac gct gtt tet 259 He Gly Ser Asn Gly Wing Gly Lys Ser Thr Leu Leu Asn Wing Val Ser 25 40 45 50 ggc cgt ttg ctt gtt gat tcc ggc gag att tcc ate gac ggc aac aag 307 Gly Arg Leu Leu Val Asp Ser Gly Glu He Ser He Asp Gly Asn Lys 55 60 65 gta aac aag atg tea gag falls aag cgt gcc cgc tac ate ggc cgc gtt 355 Val Asn Lys Met Ser Glu His Lys Arg Wing Arg Tyr He Gly Arg Val 70 75 80 85 ttc cag gat ect ctg gcc ggc acc gcg ccg aat etc acc att gaa gag 403 Phe Gln Asp Pro Leu Wing Gly Thr Wing Pro Asn Leu Thr He Glu Glu 90 95 100 • aat ctg gcc ate gcg ttg ctg cgc ggc aag cgc cgt gga ttg ggc ttt 451 Asn Leu Ala He Ala Leu Leu Arg Gly Lys Arg Arg Gly Leu Gly Phe 105 110 115 gca ctg acc tcg aag cgc cgt gag ca t tc aag cag gaa ctt gag cgc 499 Wing Leu Thr Ser Lys Arg Arg Glu Gln Phe Lys Gln Glu Leu Glu Arg 120 125 130 ctt gag ctg ggt ctg gaa aac agg etc act gcc aaa gtt ggt ttg etc 547 Leu Glu Leu Gly Leu Glu Asn Arg Leu Thr Ala Lys Val Gly Leu Leu 135 140 145 tet ggc ggt cag cgt cag gca ttg tcc ctg ctg atg gct gt ttt act 595 Be Gly Gly Gln Arg Gln Wing Leu Be Leu Leu Met Wing Gly Phe Thr 10 150 155 160 165 caá ect aaa ate atg ctg gat gag falls acc gca gcg ctt gat cca 643 Gln Pro Lys He Met Leu Leu Asp Glu His Thr Wing Ala Leu Asp Pro 170 175 180 • cag cgt gca gag ctt gtg acc acctt acc acct aga gtg gca gat 691 Gln Arg Ala Glu Leu Val Thr Thr Leu Thr Glu Lys He Val Wing Asp 185 190 195 gga aat ctg act acg ctt atg gtc acg falls aac atg gaa cag gca att 739 Gly Asn Leu Thr Thr Leu Met Val Thr His Asn Met Glu Gln Wing He 200 205 210 cgc ctg ggc aat cgc ctg ate atg cat gaa ggc cag att gtc tac 787 Arg Leu Gly Asn Arg Leu He Met Met His Glu Gly Gln He Val Tyr 15 215 220 225 cag gca gat cag gct acc aag tcg aag ttg act gtg cgc gat ttg ctg 835 Gln Wing Asp Gln Wing Thr Lys Ser Lys Leu Thr Val Arg Asp Leu Leu 230 235 240 245 cag gag ttc gcc aac ate aag ggc gca here ttg tet gac aag gcg ttc 883 Gln Glu Phe Wing Asn He Lys Gly Wing Thr Leu Ser Asp Lys Wing Phe 250 255 260 etc ggc taaaaagagc ttget .ttacg ac •• g 912 Leu Gly • < 210 > 522 20 < 211 > 263 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 522 Met Leu Ser He Asn Gly He Ser Lys Thr Phe Phe Pro Gly Thr Val 1 5 10 15 Asn Glu Arg Arg Ala Leu Gln Gln Leu Lys Leu Asp Met Wing Glu Gly 20 25 30 Asp Phe Val Thr Val He Gly Ser Asn Gly Wing Gly Lys Ser Thr Leu 35 40 45 Leu Asn Wing Val Ser Gly Arg Leu Leu Val Asp Ser Gly Glu He Ser 25 50 55 60 LA i- He Asp Gly Asn Lys Val Asn Lys Met Ser Glu His Lys Arg Wing Arg 65 70 75 80 Tyr He Gly Arg Val Phe Gln Asp Pro Leu Wing Gly Thr Wing Pro Asn 85 90 95 Leu Thr He Glu Glu Asn Leu Wing He has Wing Leu Leu Arg Gly Lys Arg 100 105 110 Arg Gly Leu Gly Phe Wing Leu Thr Ser Lys Arg Arg Glu Gln Phe Lys 115 120 125 Gln Glu Leu Glu Arg Leu Glu Leu Gly Leu Glu Asn Arg Leu Thr Wing • 130 135 140 Lys Val Gly Leu Leu Ser Gly Gly Gln Arg Gln Ala Leu Ser Leu Leu 145 150 155 160 Met Wing Gly Phe Thr Gln Pro Lys He Met Leu Leu Asp Glu His Thr 165 170 175 Ala Ala Leu Asp Pro Gln Arg Ala Glu Leu Val Thr Thr Leu Thr Glu 180 185 190 Lys He Val Wing Asp Gly Asn Leu Thr Thr Leu Met Val Thr His Asn 195 200 205 Met Glu Gln Wing He Arg Leu Gly Asn Arg Leu He Met Met His Glu 210 215 220 10 Gly Gln He Val Tyr Gln Wing Asp Gln Wing Thr Lys Ser Lys Leu Thr 225 230 235 240 Val Arg Asp Leu Leu Gln Glu Phe Wing Asn He Lys Gly Wing Thr Leu 245 250 255 Being Asp Lys Wing Phe Leu Gly 260 < 210 > 523 < 211 > 817 < 212 > DNA < 213 > Corynebacterium glutamicum 15 < 220 > < 221 > CDS < 222 > (101) .. (817) < 223 > RXA00369 < 400 > 523 ggcgggaaat 1: acaatcagg catcggcgtt gtcgttgatg tttgcgatta tcggtatcgt 60 ggcgctcgcg ttgacggtgc gcagccagaa ggagttttag gtg tea tcg ate aaa 115 Val Ser Ser He Lys • 1 5 ttg cgc gat tta age gtg age ttc cgc gac gga acc ttc ggg ctg caa 163 Leu Arg Asp Leu Ser Val Be Phe Arg Asp Gly Thr Phe Gly Leu Gln 20 10 15 20 gat ate aat ttg aaa att gag ccg gaa gaa ttt gtg gtg etc ate ggg 211 Asp He Asn Leu Lys He Glu Pro Glu Glu Phe Val Val Leu He Gly 25 30 35 ccg tcg ggg tcc ggt aaa acc acc atg ttg ggc acc ate gcg ggg ttt 259 Pro Ser Gly Be Gly Lys Thr Thr Met Leu Gly Thr He Wing Gly Phe 40 45 50 gtg gag cca agt tcc ggc agt gtg etc ate gcc ggc gaa gaa atg acg 307 Val Glu Pro Ser Ser Gly Ser Val Leu He Wing Gly Glu Glu Met Thr 55 60 65 cat gtc ccg ccg gag cgc cgt cgc atg ggc atg gtg ttt cag cag cat 355 His Val Pro Pro Glu Arg Arg Arg Met Gly Met Val Phe Gln Gln His 25 70 75 80 85 gcg gtg tgg ccg cat atg tcg gtc gcc aag aat gtg gga tac ccg ctg 403 Wing Val Trp Pro HJ.S Met Ser Val Ala Lys Asn Val Gly Tyr Pro Leu 90 95 100 gcg cga agg ggt cag aag ggg gcg tcg ata age aaa cgc gtg gag cgc 451 Wing Arg Ser Gly Gln Lys Gly Wing Ser He Ser Lys Arg Val Glu Arg 105 110 115 acg etc gcg ctg gtg ggg ctt gag ggg ttc ggc agt cgc aga ccg gcc 499 Thr Leu Ala Leu Val Gly Leu Glu Gly Ghe Phe Gly Ser Arg Arg Pro Wing 120 125 130 age ctg tet ggt ggt cag cgt cag cgg gtg gcg ctt gcg cgc gcc ate 547 Ser Leu Be Gly Gly Gln Arg Gln Arg Val Wing Leu Wing Arg Wing 135 140 145 ate gcc gac ccc acc gtg ctg ctt etc gac gac gcc etc tcc gcc etc 595 Wing Asp Pro Thr Val Leu Leu Leu Asp Glu Ala Leu Ser Ala Leu 150 155 160 165 gac gaa ccg ctg cga gac gct tta cga cgc gaa etc gta tet ttg acc 643 Asp Glu Pro Leu Arg Asp Ala Leu Arg Arg Glu Leu Val Ser Leu Thr 170 175 180 cgg cgc gaa ggc etc act act gtg cae gtg acg cat gac cgc gcc gaa 691 Arg Arg Glu Gly Leu Thr Thr Val His Val Thr His Asp Arg Ala Glu 10 185 190 195 gcg ate tcc ate gct gac cgc ate gtc gta etc ggc aac ggt cga ate 739 Wing I Ser Ser Ala Asp Arg He Val Val Leu Gly Asn Gly Arg He 200 205 210 • cag gta gcc acc ect act gag etc ctt tcc gcc ccc gct act gcc 787 Gln Gln Val Ala Thr Pro Thr Glu Leu Leu Ser Ala Pro Ala Thr Ala 215 220 225 gat gtt gcc cga ttc ate gtc gac gcc acc 817 Asp Val Ala Arg Phe He Val Asp Ala Thr 230 235 <; 210 > 524 15 < 211 > 239 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 524 Val Ser Ser He Lys Leu Arg Asp Leu Ser Val Ser Phe Arg Asp Gly 1 5 10 15 Thr Phe Gly Leu Gln Asp Xle Asn Leu Lys He Glu Pro Glu Glu Phe 20 25 30 • Val Val Leu He Gly Pro Ser Gly Ser Gly Lys Thr Thr Met Leu Gly 35 40 45 Thr He Wing Gly Phe Val Glu Pro Ser Ser Gly Ser Val Leu He Wing 20 50 55 60 Gly Glu Glu Met Thr His Val Pro Pro Glu Arg Arg Arg M Meett Gly Met 65 70 75 80 Val Phe Gln Gln His Wing Val Trp Pro His Met Ser Val A Allaa Lys Asn 85 90 95 Val Gly Tyr Pro Leu Wing Arg Ser Gly Gln Lys Gly Wing S Seerr He Ser 100 105 111100 Lys Arg Val Glu Arg Thr Leu Ala Leu Val Gly Leu Glu GGllyy Phe Gly 115 120 125 Ser Arg Arg Pro Wing Ser Leu Ser Gly Gly Gln Arg Gln A Arrgg Val Wing 130 135 140 Leu Wing Arg Wing He He Wing Asp Pro Thr Val Leu Leu Asu Glu 25 145 150 155 160 , .l¡.

Wing Leu Wing Wing Leu Asp Glu Pro Leu Arg Asp Wing Leu Arg Arg Glu 165 170 175 Leu Val Ser Leu Thr Arg Arg Glu Gly Leu Thr Thr Val His Val Thr 180 185 190 His Asp Arg Wing Glu Wing He Ser He Wing Asp Arg He Val Val Leu 195 200 205 Gly Asn Gly Arg He Gln Gln Val Wing Thr Pro Thr Glu Leu Leu Ser 210 215 220 Wing Pro Wing Thr Wing Asp Val Wing Arg Phe He Val Asp Wing Thr 225 230 235 < 210 > 525 < 211 > 1653 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1630) < 223 > RXA02073 < 400 > 525 tcattgtttt; agaggatggc caattgacca tgatggatac accicageaac < gtttieccage 60 acaatgcgtt 1tttClegeace gctgtgatgg aggaag, aaca atg att tcc cga ctt 115 Met He Ser Arg Leu 1 5 etc cata ttg gct aag aaa gta tgg ccg gaa ctt gga gcc tcc acg etc 163 Leu Gln Leu Wing Lys Lys Val Trp Pro Glu Leu Gly Wing Ser Thr Leu 10 15 20 ctg cga ctg etc aat cag cta etc acc gca gca etc att gtg ttc ccc 211 Leu Arg Leu Leu Asn Gln Leu Leu Thr Ala Wing Leu He Val Phe Pro 25 30 gcc tgg gtg cta age cgc aaa cca gac ate tcc ctg etc gcc gtc gcc 259 Wing Trp Val Leu Ser Arg Lys Pro Asp He Ser Leu Leu Wing Val Wing 40 45 50 ate ate atg gcg etc ate gcg ctg here gca gct gtc tgt cgc tgg ggt 307 He He Met Wing Ala Leu Wing Wing Leu Thr Wing Wing Val Cys Arg Trp Gly 55 60 65 gag cag gta tgc ggc drops cgc gct gcc ttt ggg ctg ctt gcc drops atg 355 Glu Gln Val Cys Gly His Arg Ala Ala Phe Gly Leu Leu Ala His Met 70 75 80 85 cgc gtt atg ctt tac gac gcc etc gtc falls aaa ggt tcc ccc tcg ccg 403 Arg Val Met Leu Tyr Asp Ala Leu Val His Lys Gly Ser Pro Pro 90 95 100 ate fall ggc age ggt tcg ate atg tet gtt gcc acc cgt gac att aac 451 He His Gly Ser Gly Ser He Met Ser Val Wing Thr Arg Asp He Asn 105 110 115 tcc ate gaa gta ttc tc gcg falls acc ggg ect here gtc ac gca 499 Be He Glu Val Phe Phe Wing His Thr He Gly Pro Thr Val Thr Wing 120 125 130 gtg ctg etc agt gcg gga ggc gtg ate acg ctg gca acg etc gat ccc 547 Val Leu Leu Be Wing Gly Gly Val He Thr Leu Wing Thr Leu Asp Pro 135 140 145 gtt gct ggt cta att ggt tta etc ggt gtc etc ate gcg tgg ttg ate 595 Val Ala Gly Leu He Gly Leu Leu Gly Val Leu He Ala Trp Leu He 150 155 160 165 ccc ttg att gga aaa caá tcc tea age agt gaa gcc here tea cgt gga 643 Jj ^ jfa ^ j ^ Pro Leu He Gly Lys Gln Ser Ser Ser Glu Wing Thr Ser Arg Gly 170 175 180 falls ate gcc cag falls etc acc gaa gat gcc gcc ggc agg ctt gaa ate 691 His He Wing Gln His Leu Thr Glu Asp Wing Wing Gly Arg Leu Glu He 185 190 195 aac tea cat gga gcg caa gcc here cgg tta aat gcg etc gag gtg aaa 739 Asn Ser His Gly Ala Gln Ala Thr Arg Leu Asn Ala Leu Glu Val Lys 200 205 210 5 gag caa caa ctg gaa caa gtt gtg acc cga cag ggc ttg ate gtc ggt 787 • Glu Gln Gln Leu Glu Gln Val Val Thr Arg Gln Gly Leu He Val Gly 215 220 225 ate cgt cag ggc gca gca ctt tta tgg ccg tgg ata gct gtg ttg 835 He Arg Gln Gly Ala Ala Leu Leu Trp Pro Trp He Ser Wing Val Leu 230 235 240 245 ttg gtt gtt ctg gtt ect cat gtg ggc att gtt gca gcc gcg att ate 883 Leu Val Ala Leu Val Pro His Val Gly He Val Ala Ala Ala He He 250 255 260 ctg ggc ate tcc ect gcg ttg gat gca gtt gag gga ttt gct cgc acc 931 Leu Gly He Ser Pro Ala Leu Asp Ala Val Glu Gly Phe Ala Arg Thr 265 270 275 10 atg ect acc gcg tta aac agt gcg cag cgg tat ttc cag ate ate gat 979 Met Pro Thr Ala Leu Asn Be Ala Gln Arg Tyr Phe Gln He He Asp 280 285 290 gcc ect gtt gct ate gct gaa ect gac gag ccg aag ect ttg ccc aaa 1027 Ala Ala He • Pro Val Ala Glu Pro Asp Glu Pro Lys Pro Leu Pro Lys 295 300 305 ggc ccg ctt aag ctg cga att tet aga gtt cca gtc age gca aag ggc 1075 Gly Pro Leu Lys Leu Arg He Ser Arg Val Pro Val Ser Wing Lys Gly 310 315 320 325 acc gtg tet tta gag gtt gca gct ggt gaa cae ate ggc ate ate gga 1123 Thr Val Ser Leu Glu Val Wing Wing Gly Glu His He Gly He He Gly 330 335 340 15 tcc age ggt agt gga aaa tcc act ttg gcc aaa etc ate etc aag ctg 1171 Be Ser Gly Be Gly Lys Be Thr Leu Wing Lys Leu He Leu Lys Leu 345 350 355 gcg caa cta cgg tet gga acc ate acc ate ggt ggt gtt gat ate gca gt 1219 Wing Gln Leu Arg Ser Gly Thr He Thr He Gly Gly Val Asp He Wing 360 365 370 gag gtt tea tcg gcg gag ctt cgc aaa tcc gtc acg ctg gtt gag cag 1267 Glu Val Ser Ser Ala Glu Leu Arg Lys Ser Val Thr Leu Val Glu Gln 375 380 385 • aaa tet gtg ctg ttt aga gca age gtg ctg gag aat tta cgg atg ggc 1315 Lys Ser Val Leu Phe Arg Ala Ser Val Leu Glu Asn Leu Arg Met Gly 390 395 400 405 20 aat cca gag ctg tet gaa gat gaa gca agg gaa gcc ttg agg ttg gcg 1363 Asn Pro Glu Leu Ser Glu Asp Glu Wing Arg Glu Wing Leu Arg Leu Wing 410 415 420 tcg ata age gaa ctg ect tta gat gct gac gcc ctg cgc cta tet ggc 1411 Be He Be Glu Leu Pro Leu Asp Wing Asp Wing Leu Arg Leu Ser Gly 425 430 435 gga cag caa caa cgg etc tgc ctg gcg cgt gct ttg gca cgc acc ect 1459 Gly Gln Gln Gln Arg Leu Cys Leu Wing Arg Wing Leu Wing Arg Thr Pro 440 445 450 cag gta ctg att gtc gat gaa gcc acc age falls cag gat gcg etc aat 1507 Gln Val Leu He Val Asp Glu Wing Thr Ser His Gln Asp Wing Leu Asn 455 460 465 25 caa gcg gat ctt tcc cag act ctg gcc acg ctt aaa gac acc acg gtg 1555 .4:. í ,. j - i í.

Gln Wing Asp Leu Ser Gln Thr Leu Wing Thr Leu Lys Asp Thr Thr Val 470 475 480 485 ate ate att gcg falls cgc here gct gca tta acc cat gtg gat cgg ata 1603 He He He Ala His Arg Thr Ala Ala Leu Thr His Val Asp Arg He 490 495 500 att gac ctg gaa gaa ate aaa aat ccc tgatccttaa cgcggatcag 1650 He Asp Leu Glu Glu He Lys Asn Pro 505 510 1653 • ggg < 210 > 526 < 211 > 510 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 526 Met He Ser Arg Leu Leu Gln Leu Wing Lys Lys Val Trp Pro Glu Leu 1 5 10 15 Gly Wing Being Thr Leu Leu Arg Leu Leu Asn Gln Leu Leu Thr Wing Wing 20 25 30 10 Leu He Val Phe Pro Wing Trp Val Leu Ser Arg Lys Pro Asp He Ser 35 40 45 Leu Leu Ala Val Ala He He Met Ala Ala Leu Ala Ala Leu Thr Ala Ala 50 55 60 • Val Cys Arg Trp Gly Gluc Gln Val Cys Gly His Arg Ala Ala Phe Gly 65 70 75 80 Leu Leu Ala His Met Arg Val Met Leu Tyr Asp Ala Leu Val His Lys 85 90 95 Gly Ser Pro Pro He His Gly Ser Gly Ser He Met Ser Val Ala 100 105 110 Thr Arg Asp He Asn Ser He Glu Val Phe Phe Ala His Thr He Gly 115 120 125 Pro 15 Thr Val Thr Wing Val Leu Leu Ser Wing Gly Gly Val He Thr Leu 130 135 140 Wing Thr Leu Asp Pro Val Wing Gly Leu He Gly Leu Leu Gly Val Leu 145 150 155 160 He Wing Trp Leu He Pro Leu He Gly Lys Gln Ser Ser Ser Glu 165 170 175 Wing Thr Ser Arg Gly His He Wing Gln His Leu Thr Glu Asp Wing Wing 180 185 190 Gly Arg Leu Glu He Asn Ser His Gly Wing Gln Wing Thr Arg Leu Asn 195 200 205 Wing Leu Glu Val Lys Glu Gln Gln Leu Glu Gln Val Val Thr Arg Gln 210 215 220 20 Gly Leu He Val Gly He Arg Gln Gly Ala Wing Leu Leu Trp Pro Trp 225 230 235 240 He Ser Wing Val Leu Leu Val Wing Leu Val Pro His Val Gly He Val 245 250 255 Wing Wing He He Leu Gly He Ser Pro Wing Leu Asp Wing Val Glu 260 265 270 Gly Phe Wing Arg Thr Met Pro Thr Wing Leu Asn Being Wing Gln Arg Tyr 275 280 285 Phe Gln He He Asp Wing Pro Val Wing He Wing Glu Pro Asp Glu Pro 290 295 300 Lys Pro Leu Pro Lys Gly Pro Leu Lys Leu Arg He Ser Arg Val Pro 305 310 315 320 25 Val Ser Wing Lys Gly Thr Val Ser Leu Glu Val Wing Wing Gly Glu His ü¿ 325 330 335 He Gly He He Gly Ser Gly Ser Gly Lys Ser Thr Leu Wing Lys 340 345 350 Leu He Leu Lys Leu Wing Gln Leu Arg Ser Gly Thr He Thr He Gly 355 360 365 Gly Val Asp He Wing Glu Val Be Ser Wing Glu Leu Arg Lys Ser Val 370 375 380 Thr Leu Val Glu Gln Lys Ser Val Leu Phe Arg Ala Ser Val Leu Glu 385 390 395 400 Asn Leu Arg Met Gly Asn Pro Glu Leu Ser Glu Asp Glu Ala Arg Glu 405 410 415 Wing Leu Arg Leu Wing Being Ser Glu Leu Pro Leu Asp Wing Asp Wing 420 425 430 Leu Arg Leu Being Gly Gln Gln Gln Arg Leu Cys Leu Wing Arg Wing 435 440 445 Leu Wing Arg Thr Pro Gln Val Leu He Val Asp Glu Ala Thr Ser His 450 455 460 Gln Asp Ala Leu Asn Gln Wing Asp Leu Ser Gln Thr Leu Wing Thr Leu 465 470 475 480 Lys Asp Thr Thr Val He He Wing Wing His Arg Thr Ala Wing Leu Thr 485 490 495 His Val Asp Arg He He Asp Leu Glu Glu He Lys Asn Pro 500 505 510 < 210 > 527 < 211 > 1142 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (1119) < 223 > RXA01399 < 400 > 527 att etc age ccc gca acc gca ctt gtc ctg gcg att gga ttg att gct 48 He Leu Ser Pro Ala Thr Ala Leu Val Leu Ala He Gly Leu He Ala 1 5 10 15 gct gca att ate ect ccc ctg ctt gct gct cgc gga gtt aaa here gcc 96 Ala Ala He He Pro Pro Leu Leu Ala Ala Arg Gly Val Lys Thr Ala 20 25 30 gaa gcc cgg cgc gct gaa tcc age gaa gcc tac ttg agt tcc ttg gat 144 Glu Ala Arg Arg Ala Glu Be Ser Glu Ala Tyr Leu Ser Ser Leu Asp 35 40 45 cag gtg ctg tcc aac cag gcg gcg ctt cgt gtt cgt ggt gaa atg ccg 192 Gln Val Leu Ser Asn Gln Wing Wing Leu Arg Val Arg Gly Glu Met Pro 50 55 60 gcc gct ctg tcc aag gcg gat gtg gct gcg cgt tcc tat tet tet tea 240 Wing Ala Leu Ser Lys Wing Asp Val Wing Wing Arg Ser Tyr Ser Ser 65 65 75 75 75 ctg gag gca ggc gcg aaa gac act gcc ggc gca gcg agt tcc ctg 288 Leu Glu Wing Gly Wing Lys Asp Thr Wing He Gly Wing Wing Being Ser Leu 85 90 95 tgg att falls ggt ttc act gtc att ggt gtg etc atg gtt tcc gcg tea 336 Trp He His Gly Phe Thr Val He Gly Val Leu Met Val Ser Wing Ser 100 105 110 ctg tat gca gat gga age cat tea ccg cag tgg ttt ggt gtg ttg gtg 384 i - - Í-.

Leu Tyr Wing Asp Gly Ser His Ser Pro Gln Trp Phe Gly Val Leu Val 115 120 125 ctg ctt tca etc gca gct tcc gag gct gtc tet gtt etc ccc gat gct 432 Leu Leu Ser Leu Ala Wing Phe Glu Wing Val Ser Val Leu Pro Asp Wing 130 135 140 gcg att gct cgt acc cgc gcc gca gat gcc acc agg agg ctt gcg gaa 480 Wing Wing Wing Arg Thr Arg Wing Wing Asp Wing Thr Arg Arg Leu Wing Glu 145 150 155 160 - ate tcg gcg ctg cca gaa tet gtc tet ctt gag ctt cgc acg gcc tet 528 • Be Ser Ala Leu Pro Glu Ser Val Ser Leu Glu Leu Arg Thr Ala Ser 165 170 175 gac cag ccc gta tta cgc gcc gag aat cta gtt tat gga tgg gac age 576 Asp Gln Pro Val Leu Arg Ala Glu Asn Leu Val Tyr Gly Trp Asp Ser 180 185 190 gac cta ggc acg age aac ctg gat etc. acc ttt ggt tca cga cat gaa 624 Asp Leu Gly Thr Ser Asn Leu Asp Leu Thr Phe Gly Ser Arg His Glu 195 200 205 ate ate gca ccc tet gga act ggc aaa acg acc ctg ctg etc here ctt 672 He He Ala Pro Ser Gly Thr Gly Lys Thr Thr Leu Leu Leu Thr Leu 210 215 220 10 gcg ggg ctg ttg gaa ect cgt gga ggc caa gtg ctt ate gac ggc acc 720 Wing Gly Leu Leu Glu Pro Arg Gly Gly Gln Val Leu He Asp Gly Thr 225 230 235 240 aat ect tcc gag ttg aaa aac gcc gtg ctg ttc agt cca gaa gat gcc 768 • Asn Pro Ser Glu Leu Lys Asn Wing Val Leu Phe Ser Pro Glu Asp Wing 245 250 255 falls att ttt gcc acc act gtc cga gat aac tta gca etc gga gca ccg 816 His He Phe Wing Thr Thr Val Arg Asp Asn Leu Wing Leu Gly Wing Pro 260 265 270 gaa gca acc gac gcg gaa atg here tcg ate ctg gaa cat gtt ggt ttg 864 Glu Ala Thr Asp Ala Glu Met Thr Ser He Leu Glu His Val Gly Leu 275 280 285 15 tca gag tgg gtt caa ggt tta ccc gat ggt ctt ggc act gtc ctt gat 912 Ser Glu Trp Val Gln Gly Leu Pro Asp Gly Leu Gly Thr Val Leu Asp 290 295 300 tca ggt gcc gat agt etc tcg gga ggt cag cgc cgc cgc ctg etc ctt 960 Ser Gly Wing Asp Ser Leu Ser Gly Gly Gln Arg Arg Arg Leu Leu Leu 305 310 315 320 gcc cgc gta cta cta agt gat gca cca att ctg ctt ttg gat gaa ccc 1005 Wing Arg Val Leu Leu Ser Asp Ala Pro He Leu Leu Leu Asp Glu Pro 325 330 335 • acc gag falls etc gac act gca ggc tcc tet gaa ate ttg tet atg ctg 1056 Thr Glu His Leu Asp Thr Wing Gly Ser Ser Glu He Leu Ser Met Leu 340 345 350 20 cc tcc gat gaa etc ect ggt aaa aga gct agg aga acc gta gtg att 1104 Wing Being Asp Glu Leu Pro Gly Lys Arg Wing Arg Arg Thr Val Val He 355 360 365 gtg agg cat gtg agg taattttgcc ccgctgtctt ctg 1142 Val Arg His Val Arg 370 < 210 > 528 < 211 > 373 < 212 > PRT < 213 > Corynebacterium glutamicum 25 < 400 > 528 He Leu Ser Pro Wing Thr Wing Leu Val Leu Wing He Gly Leu He Wing 1 5 10 15 Wing Wing He Pro Pro Leu Leu Wing Wing Arg Gly Val Lys Thr Wing 20 25 30 Glu Wing Arg Arg Wing Glu Ser Ser Glu Wing Tyr Leu Ser Ser Leu Asp 35 40 45 Gln Val Leu Ser Asn Gln Ala Ala Leu Arg Val Arg Gly Glu Met Pro 50 55 60 Ala Ala Leu Ser Lys Ala Asp Val Ala Ala Arg Ser Tyr Ser Ser Ser • 65 70 75 80 Leu Glu Ala Gly Ala Lys Asp Thr Ala He Gly Ala Ala Ser Ser Leu 85 90 95 Trp He His Gly Phe Thr Val He Gly Val Leu Met Val Ser Wing 100 105 110 Leu Tyr Wing Asp Gly Ser His Ser Pro Gln Trp Phe Gly Val Leu Val 115 120 125 Leu Leu Ser Leu Ala Wing Phe Glu Wing Val Ser Val Leu Pro Asp Wing 130 135 140 Wing Wing Wing Arg Thr Arg Wing Wing Asp Wing Thr Arg Arg Leu Wing Glu 145 150 155 160 10 Wing Being Wing Leu Pro Glu Ser Val Being Leu Glu Leu Arg Thr Wing Being 165 170 175 Asp Gln Pro Val Leu Arg Wing Glu Asn Leu Val Tyr Gly Trp Asp Ser 180 185 190 # Asp Leu Gly Thr Ser Asn Leu Asp Leu Thr Phe Gly Ser Arg His Glu 195 200 205 He He Ala Pro Ser Gly Thr Gly Lys Thr Thr Leu Leu Leu Thr Leu 210 215 220 W Gly Leu Leu Glu Pro Arg Gly Gly Gln Val Leu He Asp Gly Thr 225 230 235 240 Asn Pro Ser Glu Leu Lys Asn Wing Val Leu Phe Ser Pro Glu Asp Wing 245 250 255 15 His He Phe Wing Thr Thr Val Arg Asp Asn Leu Ala Leu Gly Ala Pro 260 265 270 Glu Ala Thr Asp Ala Glu Met Thr Ser He Leu Glu His Val Gly Leu 275 280 285 Ser Glu Trp Val Gln Gly Leu Pro Asp Gly Leu Gly Thr Val Leu Asp 290 295 300 Se r Gly Wing Asp Ser Leu Ser Gly Gly Glg Arg Arg Arg Leu Leu Leu 305 310 315 320 Wing Arg Val Leu Leu Ser Asp Wing Pro He Leu Leu Leu Asp Glu Pro • 325 330 335 Thr Glu His Leu Asp Thr Wing Gly Being Glu He Leu Ser Met Leu 340 345 350 20 Wing Being Asp Glu Leu Pro Gly Lys Arg Wing Arg Arg Thr Val Val He 355 360 365 Val Arg His Val Arg 370 <; 210 > 529 < 211 > 1368 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS 25 < 222 > (101) .. (1345) ^. ^ ^^ M. ^ á.s < 223 > RXA01339 < 400 > 529 gag, aaggicgg, aaccgaagga a1tegaagaat atetet, cegt gcgttacctc, gett-tgccgt 60 gacacatgag > ctgt, ccggtg aataa.ccega aggaaaaaac atg act acc gaa tca 115 Met Thr Thr Glu Ser 1 5 ata gtt gcg falls aat gct gca ggt here gca ect cag aat gtg tcc tet 163 He Val Ala As Asn Ala Ala Gly Thr Ala Pro Gln Asn Val Ser Ser • 10 15 20 gct aag aag aag tac etc age gtt gcc caa ggc gtt gcc ctt ate tac 211 Wing Lys Lys Lys Tyr Leu Ser Val Wing Gln Gly Val Wing Leu He Tyr 25 30 35 gga acc aac ate ggc gcc ggt gtg etc age etc cca tac gct gcc cgc 259 Gly Thr Asn He Gly Wing Gly Val Leu Ser Leu Pro Tyr Wing Wing Arg 40 45 50 aac ggt ggt ttc etc gcc ctg gtt gtt gcc ctg etc att gcg gga here 307 Asn Gly Gly Phe Leu Wing Leu Val Val Wing Leu Leu He Wing Gly Thr 55 60 65 ctg acc acc ate tcc atg etc tac ate gcc gaa gta tcc ctg cgc acc 355 10 Leu Thr Thr He Ser Met Leu Tyr He Wing Glu Val Ser Leu Arg Thr 70 75 80 85 aag aag cca ctg cag ctt tcc ggc ctg gca gaa aaa tac cg ggg cag 403 Lys Lys Pro Leu Gln Leu Ser Gly Leu Wing Glu Lys Tyr Leu Gly Gln • 90 95 100 tgg ggc cgc tgg ctg gtg ttc att gcc att gtg gtc aac age gtg ggt 451 Trp Gly Arg Trp Leu Val Phe He Wing He Val Val Asn Ser Val Gly 105 110 115 gca ctg att gcc tac gca tca gga tcc ggc att ttg ata ggc aac etc 499 Wing Leu He Wing Tyr Wing Being Gly Ser Gly He Leu He Gly Asn Leu 120 125 130 acc ggc ctg cca cca ate gtg ggc acc ctt gga ttc ttt gtt tta ggc 547 15 Thr Gly Leu Pro Pro He Val Gly Thr Leu Gly Phe Phe Val Leu Gly 135 140 145 acc ttg ate atg tgg aaa ggc ctg falls acg gca age ttc gtg gag gca 595 Thr Leu He Met Trp Lys Gly Leu His Thr Wing Ser Phe Val Glu Wing 150 155 160 165 ttg ate acc ggc atg gca acg ate ate ate gtg ctg tgt gga tgg 643 Leu He Thr Thr Gly Met Wing Thr He He He Val Leu Cys Gly Trp 170 175 180 here gtg ctt ggc ect gga att tcc gca gac aac ctg ate gtg ttc falls 691 • Thr Val Leu Gly Pro Gly He Ser Wing Asp Asn Leu He Val Phe His 185 190 195 cca ttc ttc ate gtt ccg ate atg aac etc gcg gtc ttt acc ttc ctt 739 20 Pro Phe Phe He Val Pro He Met Asn Leu Wing Val Phe Thr Phe Leu 200 205 210 gcc ca g tat gtg gtt cca gaa ate gca cga gga gtt aac ect gcc acc 787 Wing Gln Tyr Val Val Pro Glu He Wing Arg Gly Val Asn Pro Wing Thr 215 220 225 ccg aag gca gtg cca cgc gcg ate ate ate ggc atg gtc gca act ggt 835 Pro Lys Wing Val Pro Arg Wing He He He Gly Met Val Wing Thr Gly 230 235 240 245 gtc acc ctg gca gct gta cca tcc gcg gca cta ggg ctt ctg gcc here 883 Val Thr Leu Wing Wing Val Pro Phe Wing Wing Leu Gly Leu Leu Gly Thr 250 255 260 ggc gtc agt gaa gtt gtc acc ate tcc tgg ggc gaa gca etc gcc cca 931 25 Gly Val Ser Glu Val Val Thr He Ser Trp Gly Glu Ala Leu Wing Pro 265 270 275 gtg gcc tat tac atg gcc aat gcc tcc gca cta ttg gcc atg ttc act 979 Val Ala Tyr Tyr Met Ala Asn Ala Phe Ala Leu Leu Ala Met Phe Thr 280 285 290 tea ttc ate gcc att gga ttc acc gcg atg cgc aac gta cta gat att 1027 Be Phe He Wing He Gly Phe Thr Wing Met Arg Asn Val Leu Asp He 295 300 305 ggc falls tgg cca caa falls gga tgg cag cga tcc gtt gct gtc gga cta 1075 Gly His Trp Pro Gln His Gly Trp Gln Arg Ser Val Wing Val Gly Leu 310 315 320 325 act gtt ctt cca cca ctg gca att tca ctt gcg gga tta ggc gga ttc 1123 Thr Val Leu Pro Pro Leu Ala Be Ser Leu Ala Gly Leu Gly Gly Phe 330 335 340 gtg gca gca ctg age tac gcc gga gga ttt gcc gga gca ate atg tcc 1171 Val Ala Ala Leu Ser Tyr Ala Gly Gly Phe Ala Gly Ala He Met Ser 345 350 355 ate ate ccc gtg ctg ttg ctg cgc aac tcc cgc aag agt ggc gac caa 1219 He He Pro Val Leu Leu Leu Arg Asn Ser Arg Lys Ser Gly Asp Gln 360 365 370 gaa cca gtg tgg aaa gcc acc tgg caa gcg cae ccc ate ttc cag ate 1267 10 Glu Pro Val Trp Lys Wing Thr Trp Gln Wing His Pro He Phe Gln He 375 380 385 ctg ttg att gtg gtg tac tcc ctg gcg ttt gtg tac tcg gtt etc gcg 1315 Leu Leu He Val Val Tyr Ser Leu Ala Phe Val Tyr Ser Val Leu Ala 390 395 400 405 • ate gtc gga tta atg ect gcg ggt tgg gca tagt: cacttc ctgttgtggc 1365 He Val Gly Leu Met Pro Wing Gly Trp Wing 410 415 tgc 1368 < 210 > 530 < 211 > 415 15 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 530 Met Thr Thr Glu Ser He Val Wing His Asn Wing Wing Ala Gly Thr Wing Pro 1 5 10 15 Gln Asn Val Ser Being Wing Lys Lys Lys Tyr Leu Ser Wing Wing Gln Gly 20 25 30 Val Wing Leu He Tyr Gly Thr Asn He Gly Wing Gly Val Leu Ser Leu 35 40 45 • Pro Tyr Wing Wing Arg Asn Gly Gly Phe Leu Wing Leu Val Val Wing Leu 50 55 60 20 Leu He Wing Gly Thr Leu Thr Thr He Ser Met Leu Tyr He Wing Glu 65 70 75 80 Val Ser Leu Arg Thr Lys Pro Leu Gln Leu Ser Gly Leu Ala Glu 85 90 95 Lys Tyr Leu Gly Gln Trp Gly Arg Trp Leu Val Phe He Wing He Val 100 105 110 Val Asn Ser Val Gly Ala Leu He Ala Tyr Ala Ser Gly Ser Gly He 115 120 125 Leu He Gly Asn Leu Thr Gly Leu Pro Pro He Val Gly Thr Leu Gly 130 135 140 Phe Phe Val Leu Gly Thr Leu He Met Trp Lys Gly Leu His Thr Ala 145 150 155 160 25 Ser Phe Val Glu Ala Leu He Thr Thr Gly Met Ala Thr He He He 165 170 175 Val Leu Cys Gly Trp Thr Val Leu Gly Pro Gly He Ser Wing Asp Asn 180 185 190 Leu He Val Phe His Pro Phe He Val Val Pro He Met Asn Leu Wing 195 200 205 V al Phe Thr Phe Leu Wing Gln Tyr Val Val Pro Glu He Wing Arg Gly 210 215 220 Val Asn Pro Wing Thr Pro Lys Wing Val Pro Arg Wing He He He Gly 225 230 235 240 Met Val Ala Thr Gly Val Thr Leu Ala Ala Val Pro Phe Ala Ala Leu 245 250 255 Gly Leu Leu Gly Thr Gly Val Ser Glu Val Val Thr He Ser Trp Gly 260 265 270 Glu Ala Leu Ala Pro Val Ala Tyr Tyr Met Ala Asn Ala Phe Ala Leu 275 280 285 Leu Wing Met Phe Thr Ser Phe He Wing He Gly Phe Thr Wing Met Arg 290 295 300 Asn Val Leu Asp He Gly His Trp Pro Gln His Gly Trp Gln Arg Ser 305 310 315 320 Val Wing Val Gly Leu Thr Val Leu Pro Pro Leu Wing He Ser Leu Wing 325 330 335 Gly Leu Gly Gly Phe Val Wing Wing Leu Ser Tyr Wing Gly Gly Phe Wing 340 345 350 Gly Wing He Met Being He He Pro Val Leu Leu Leu Arg Asn Ser Arg 355 360 365 Lys Ser Gly Asp Gln Glu Pro Val Trp Lys Wing Thr Trp Gln Wing His 370 375 380 Pro He Phe Gln He Leu Leu He Val Val Tyr Ser Leu Ala Phe Val 385 390 395 400 Tyr Ser Val Leu Wing He Val Gly Leu Met Pro Wing Gly Trp Wing 405 410 415 < 210 > 531 < 211 > 1452 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1429) < 223 > RXA02527 < 400 > 531 attggageaa tcttttaatc aagttgggaa ttccagcgtt gattgtggtt gccatgtggt 60 ttgcccgcac cctgaagcac tcacggatca agcgtggcgg atg ttt ggc ctg ttc 115 Met Phe Gly Leu Phe 1 5 ate gcg acg att gtg gcg att att aag cca atg cca atg ggt gcc 163 He Ala Thr He Val Ala He He Leu Lys Pro Met Pro Met Gly Wing 10 15 20 gtg here att ate ggc atg ate gcc gcg gtg ttg act ggt ttg gtg ccg 211 Val Thr He He Gly Met He Ala Wing Val Leu Thr Gly Leu Val Pro 25 30 35 ttg acg gcg tet tet gat gat ccc ggc gcg gtg tat ggc ctt att ggt 259 Leu Thr Wing Being Ser Asp Pro Gly Wing Val Tyr Gly Leu He Gly 40 45 50 ttc agt aac ggc acc att tgg ctg att gtg atg gcg ttc ctg att tcg 307 Phe Ser Asn Gly Thr He Trp Leu He Val Met Wing Phe Leu He Ser 55 60 65 cgt gga ttc ate aag acg ggg ctt gga cgt cga ata gcg ttg ttc ttt 355 Arg Gly Phe He Lys Thr Gly Leu Gly Arg Arg He Ala Leu Phe Phe 70 75 80 85 gtg tet aaa gtc ggc gga aaa atg ctg ggt gtg acc tat ggt ttg gcg 403 Val Ser Lys Val Gly Gly Lys Met Leu Gly Val Thr Tyr Gly Leu A the 90 95 100 etc gct gat ttg gtg gtg tct gct gcg att cca tca gca act gcc cga 451 Leu Wing Asp Leu Val Leu Wing Pro Wing Pro Pro Wing Thr Wing Arg 105 110 115 ggt ggt ggt att atg gct ccg att atg aag tcg gtg gca ttg act tat 499 Gly Gly He Met Wing Pro He Met Lys Ser Val Wing Leu Thr Tyr 120 125 130 gat tcc act ect ggc cca act cgc cgc agg gct gcg gcg ttc gt gg 547 Asp Ser Thr Pro Gly Pro Thr Arg Arg Arg Ala Gly Ala Phe Leu Ala 135 140 145 ctg aat gtg gga cag gta aat gcg att acg tgc gcg atg ttt cta act 595 Leu Asn Val Gly Gln Val Asn Ala He Thr Cys Ala Met Phe Leu Thr 150 155 160 165 gca atg gca gga aac ccc ttg ate gcc tet ttg gct tcg cag atg gat 643 10 Wing Met Wing Gly Asn Pro Leu Wing Wing Being Leu Wing Being Gln Met Asp 170 175 180 gtc aat ate acg tgg here aac tgg gctg ggt gcg att gtg ect ggt 691 • Val Asn He Thr Trp Thr Asn Trp Wing Val Gly Wing He Val Pro Gly 185 190 195 ctg gtg gcg ctt att gtg gtg ccg tgg gtg gta tac aag ate tat cca 739 Leu Val Ala Leu He Val Val Pro Trp Val Val Tyr Lys He Tyr Pro 200 205 210 ect gag ttg aag gac acc ect gag gtc aa g aaaa atg gct tet gat gag 787 Pro Glu Leu Lys Asp Thr Pro Glu Val Lys Lys Met Wing As As Glu 215 220 225 15 etc aag caa ttg ggt ggg ttt act tat ggt gag aag gtg ctg gcg gga 835 Leu Lys Gln Leu Gly Gly Phe Thr Tyr Gly Glu Lys Val Leu Wing Gly 230 235 240 245 acc ttt gtt gtg ttg ctg ctg etc tgg here ggt ggc gat ttg gtc ttg 883 Thr Phe Val Val Leu Leu Leu Leu Trp Thr Gly Gly Asp Leu Val Leu 250 255 260 gga ate tcg gca act acc gct tct gtt ggc gtc ate ate ttg cta 931 Gly He Ser Ala Thr Thr Thr Ala Phe Val Gly Val He He Leu Leu 265 270 275 • gtg gct falls gtg ctg acg tgg gag gac ate att caa gaa aag act gcg 979 Val Ala His Val Leu Thr Trp Glu Asp He He Gln Glu Lys Thr Ala 280 285 290 tgg gac acc atg gtg tgg ttc gcg gtg cta tac atg atg gca here gcg 1027 20 Trp Asp Thr Met Val Trp Phe Wing Val Leu T Tyyrr Met Met Wing Thr Wing 295 300 305 tta tcg cag tac gga ttc ate gca tgg ate tteett ggaagg ggttaa aatttt ggcctt ttcccc 1075 Leu Ser Gln Tyr Gly Phe He Wing Trp He Ser Glu Val He Ala Ser 310 315 320 325 agt ttg ggt ggc atg aac tgg gtc gtt gtt gt gtt ttg gtg gtg ctg 1123 Ser Leu Gly Gly Met Asn Trp Val Val Ala Leu Val Val Leu Val Leu 330 335 340 att tac ttc ttc agt cae tat ttc ttt gcc tcg gca here gcg cat att 1171 He Tyr Phe Phe Ser His Tyr Phe Phe Wing Ser Wing Thr Wing His He 345 350 355 25 tet gcg atg tac ttg gcc ttc ctg ggt gct gcg att gcg att ggt gca 1219 Ser Ala Met Tyr Leu Wing Phe Leu Gly Wing Wing He Wing He Gly Wing 360 365 370 ccc ccg ttg atg gcg gcc ctg gtg ttg gcg tac acc tcc aat ttg ttc 1267 Pro Pro Leu Met Ala Ala Leu Val Leu Ala Tyr Thr Ser Asn Leu Phe 375 380 385 tet tca etc act cag tat tet ggt ggt ect tcg cca here ttg ttt ggt 1315 Be Ser Leu Thr Gln Tyr Be Gly Pro Gly Pro Pro Thr Leu Phe Gly 390 395 400 405 ttg aac tac ate acg gtg ggt gag tgg tgg cgg acc tcg gca att gct 1363 Leu Asn Tyr He Thr Val Gly Glu Trp Trp Arg Thr Ser Wing Wing 410 415 420 ggc gcg gta tcg att here ate tgg ttg gtt ate ggt ggt ttg tgg atg 1411 Gly Ala Val Ser He Thr He Trp Leu Val He Gly Gly Leu Trp Met 425 430 435 aat gtc ate gga etc tgg taatcgaaaa ttaaaggtaa ggg 1452 Asn Val He Gly Leu Trp 440 < 210 > 532 < 211 > 443 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 532 Met Phe Gly Leu Phe He Wing Thr He Val Wing He He Leu Lys Pro 1 5 10 15 Met Pro Met Gly Wing Val Thr He He Gly Met He Wing Wing Val Leu 20 25 30 Thr Gly Leu Val Pro Leu Thr Wing Being Asp Asp Pro Gly Ala Val 35 40 45 Tyr Gly Leu He Gly Phe Ser Asn Gly Thr He Trp Leu He Val Met 50 55 60 Wing Phe Leu He Ser Arg Gly Phe He Lys Thr Gly Leu Gly Arg Arg 65 70 75 80 He Ala Leu Phe Phe Val Ser Lys Val Gly Gly Lys Met Leu Gly Val 85 90 95 Thr Tyr Gly Leu Ala Leu Ala Asp Leu Val Leu Ala Pro Ala He Pro 100 105 110 Be Ala Thr Ala Arg Gly Gly Gly He Met Ala Pro He Met Lys Ser 115 120 125 Val Wing Leu Thr Tyr Asp Ser Thr Pro Gly Pro Thr Arg Arg Arg Wing 130 135 140 Gly Wing Phe Leu Wing Leu Asn Val Gly Gln Val Asn Wing He Thr Cys 145 150 155 160 Wing Met Phe Leu Thr Wing Met Ala Gly Asn Pro Leu He Ala Be Leu 165 170 175 Wing Being Gln Met Asp Val Asn He Thr Trp Thr Asn Trp Wing Val Gly 180 185 190 Wing He Val Pro Gly Leu Val Wing Leu He Val Val Pro Trp Val Val 195 200 205 Tyr Lys He Ty Pro Pro Glu Leu Lys Asp Thr Pro Glu Val Lys Lys 210 215 220 Met Wing Wing Asp Glu Leu Lys Gln Leu Gly Gly Phe Thr Tyr Gly Glu 225 230 235 240 Lys Val Leu Wing Gly Thr Phe Val Val Leu Leu Leu Leu Trp Thr Gly 245 250 255 Gly Asp Leu Val Leu Gly He Ser Wing Thr Thr Thr Wing Phe Val Gly 260 265 270 Val He He Leu Leu Val Wing His Val Leu Thr Trp Glu Asp He He 275 280 285 Gln Glu Lys Thr Wing Trp Asp Thr Met Val Trp Phe Wing Val Leu Tyr 290 295 300 Met Met Wing Thr Wing Leu Ser Gln Tyr Gly Phe He Wing Trp He Ser 305 310 315 320 Glu Val He Wing Ser Ser Leu Gly Gly Met Asn Trp Val Val Wing Leu w 325 330 335 Val Val Leu Val Leu He Tyr Phe Phe Ser His Tyr Phe Phe Wing Ser 340 345 350 Wing Thr Ala His I Have Wing Met Wing Tyr Leu Wing Phe Leu Gly Wing Wing 355 360 365 Wing Wing He Gly Wing Pro Pro Leu Wing Wing Wing Leu Val Leu Wing Tyr 370 375 380 Thr Being Asn Leu Phe Being Being Leu Thr Gln Tyr Being Gly Gly Pro Being 385 390 395 400 Pro Thr Leu Phe Gly Leu Asn Tyr He Thr Val Gly Glu Trp Trp Arg 405 410 415 Thr Ser Wing Wing Wing Gly Wing Val Ser He Thr He Trp Leu Val He 10 420 425 430 Gly Gly Leu Trp Met Asn Val He Gly Leu Trp 435 440 f <; 210 > 533 < 211 > 1968 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1945) 15 < 223 > RXN00298 < 400 > 533 tttagacaag ttctggttaa aattcttcat gaaggtgaga atctgggaat ttctcggtac 60 tctttcagat tcgtagttat ccactgattg gaagaatgag atg age tca aat ata 115 Met Ser Ser Asn He 1 5 gct ate acg acc gag ect gaa ggg aaa aat aaaaag ggt etc aaa tca 163 Ala He Thr Thr Glu Pro Glu Gly Lys Asn Lys Lys Gly Leu Lys Ser • 10 15 20 gac ccg ttc att ttt tcc att tet gtc ggt ttt ate gtg gtg ttt gtc 211 Asp Pro Phe He Phe Ser He Ser Val Gly Phe He Val Val Phe Val 20 25 30 35 ate gcc here att gcg cta ggc gag aaa gct cga here acc ttt tcc gcg 259 He Ala Thr He Ala Leu Gly Glu Lys Wing Arg Thr Thr Phe Ser Wing 40 45 50 att gcc ggc tgg etc tta gaa aat tta ggg tgg atg tat ate ggg ggt 307 He Wing Gly Trp Leu Leu Glu Asn Leu Gly Trp Met Tyr He Gly Gly 55 60 65 gtc tcc ttg gtt ttc att ttc etc atg ggt ate ttt gcg tcc cgg tat 355 Val Ser Leu Val Phe He Phe Leu Met Gly He Phe Ala Ser Arg Tyr 70 75 80 85 ggc cgg gta aaa ctt ggt gat gac gat gat gac ccc gag drops acc 405 Gly Arg Val Lys Leu Gly Asp Asp Asp Asp Asp Pro Glu His Thr Leu 25 90 95 100 ate gtg tgg ttc tgt atg ctt ttt gct ggc ggt gtc ggt gca gtc tta 451 He Val Trp Phe Cys Met Leu Phe Wing Gly Gly Val Gly Wing Val Leu 105 110 115 atg ttt tgg ggt gtt gtt gaa ccg att aac falls gcg ttc aac gtg cca 499 Met Phe Trp Gly Val Wing Glu Pro He Asn His Wing Phe Asn Val Pro 120 125 130 atg gct aat gaa gaa tcc atg agt gaa gcc gca att gtg cag gct ttt 547 Met Wing Asn Glu Glu Ser Met Ser Glu Ala Ala He Val Gln Ala Phe 135 140 145 • gct tat act ttc tat falls ttc ggt att falls atg tgg gta ate atg gca 595 Wing Tyr Thr Phe Tyr His Phe Gly He His Met Trp Val He Met Wing 150 155 160 165 etc cca gga tta tca ttg gga tac ttt att tac aaa cgt aag cta ect 643 Leu Pro Gly Leu Ser Leu Gly Tyr Phe He Tyr Lys Arg Lys Leu Pro 170 175 180 ccc cgt cta tcc tet gtg ttt tet ccg ate ttg ggt aag falls att tat 691 Pro Arg Leu Ser Ser Val Phe Ser Pro He Leu Gly Lys His He Tyr 185 190 195 tcc here ccc ggc aag etc ate gat gta ctg gcc ate gta ggc acc ac 739 Ser Thr Pro Gly Lys Leu He Asp Val Leu Wing He Val Gly Thr Thr 10 200 205 210 ttt ggt att gct gtg tca gta ggt ctt ggt gtg ctg caa ate aat gca 787 Phe Gly He Ala Val Ser Val Gly Leu Gly Val Leu Gln He Asn Ala 215 220 225 • ggt atg aaa aaa cta tgg age acc ccg caa gta tcg tgg gtt cag ctt 835 Gly Met Asn Lys Leu Trp Ser Thr Pro Gln Val Ser Trp Val Gln Leu 230 235 240 245 ttg ate ate ttg ate ate acc gcg gtt gca tgt att tcc gtt gct tcc 883 Leu He He Leu He He Thr Ala Val Ala Cys He Ser Val Ala Ser 250 255 260 ggt ttg gat aag ggc att aag tta ctg tcc aac att aat att gca atg 931 Gly Leu Asp Lys Gly He Lys Leu Leu Be Asn He Asn He Wing Met 15 265 270 275 gcc gtt gcg ttg atg ttc ttc ttc ate ttg ttc act ggt cca acc etc here 979 Wing Val Wing Leu Met Phe Phe He Leu Phe Thr Gly Pro Thr Leu Thr 280 285 290 ttg ctg cgc ttt etc gta gaa tcc ttc gga ate tat gca tcc tgg tg atg 1027 Leu Leu Arg Phe Leu Val Glu Ser Phe Gly He Tyr Ala Ser Trp Met 295 300 305 ect aat ctg att ttt tgg act gac tet ttc caa gat aac cca ggc tgg 107 5 Pro Asn Leu Met Phe Trp Thr Asp Ser Phe Gln Asp Asn Pro Gly Trp • 310 315 320 325 cag ggc aaa tgg acg gtg ttc tat tgg gca tgg act att tgt tgg tcg 1123 Gln Gly Lys Trp Thr Val Phe Tyr Trp Wing Trp Thr He Cys Trp Ser 20 330 335 340 cca tat gtc ggc atg ttc gtg gcg cgt att tcg cgt gga cgt acc gtc 1171 Pro Tyr Val Gly Met Phe Val Wing Arg He Ser Arg Gly Arg Thr Val 345 350 355 cgt gaa ttt ate ggt ggg gtt cta gct ctg cca gcg ate ttt ggc gta 1219 Arg Glu Phe He Gly Gly Val Leu Ala Leu Pro Wing He Phe Gly Val 360 365 370 gtt tgg ttc tet ate ttt ggt cgt gca ggc ate gaa gtg gaa ctg agt 1267 Val Trp Phe Be He Phe Gly Arg Wing Gly He Glu Val Glu Leu Ser 375 380 385 aac cca ggt ttc ttg acc cag cca act gtt gtt gag ggt gac gtg cca 1315 Asn Pro Gly Phe Leu Thr Gln Pro Thr Val Val Glu Gly Asp Val Pro 25 390 395 400 405 «.- ^ 1 *». ^ - ~ jjj gca gcg ctt ttt aat gtg ctg caa gag tat ccg ctg act gga att gtc 1363 Wing Ala Leu Phe Asn Val Leu Gln Glu Tyr Pro Leu Thr Gly He Val 410 415 420 tcc gcg ttt gca ctt gta att att gtg att ttc ttt ate acc tcc ate 1411 Be Ala Phe Ala Leu Val He He Val He Phe Phe He Thr Ser He 425 430 435 gat tcc gca gcg cta gtt aac gat atg ttc gct acc ggt gca gaa aat 1459 Asp Ser Wing Wing Leu Val Asn Asp Met Phe Wing Thr Gly Wing Glu Asn 440 445 450 caa here ccg act agt tac cgc gtg atg tgg gcc tgc acc att ggg gcg 1507 Gln Thr Pro Thr Ser Tyr Arg Val Met Trp Wing Cys Thr He Gly Wing 455 460 465 gtc gca ggt tcc ttg ctg ate att ccc tcc tet ggt att gcc acg 1555 Val Ala Gly Ser Leu Leu He He Ser Pro Pro Ser Gly He Ala Thr 470 475 480 485 ctg caa gaa gtg gtt ate ate gtg gct tcc cca ttc ttc etc gtg caa 1603 Leu Gln Glu Val Val He He Val Val Phe Pro Phe Phe Leu Val Gln 490 495 500 ttt gtc atg att ttt tt ttg ctt aaa ggc atg agt gaa gat gct gct 1651 Phe Val Met Met Phe Ser Leu Leu Lys Gly Met Ser Glu Asp Wing Ala 10 505 510 515 gcg gtt cgt cgt gtg cag act cgt cag tgg gaa agact act cca 1699 Wing Val Arg Arg Val Gln Thr Arg Gln Trp Glu Lys Thr Asp Thr Pro 520 525 530 gaa aaa ctt gaa gag cat tcg tcc caa cca gcc ccg ggc tat gat gac 1747 • Glu Lys Leu Glu Glu His Ser Ser Gln Pro Pro Pro Gly Tyr Asp Asp 535 540 545 gag ggc aac ccc ttg cca atg ect gcc etc gaa cat gat gag gac ggt 1795 Glu Gly Asn Pro Leu Pro Met Pro Ala Leu Glu His Asp Glu Asp Gly 550 555 560 565 aac att gtt ate cca ggc aac gta gtc att gaa ggt gat ctt ggg gta 1843 Asn He Val He Pro Gly Asn Val Val He Glu Gly Asp Leu Gly Val 15 570 575 580 gtt ggt gat gtg gtc gac gat ect gag gaa gcc caa gag atg ggg tet 1891 Val Gly Asp Val Val Asp Asp Pro Glu Glu Wing Gln Glu Met Gly Ser 585 590 595 cgt ttt aag ate gtc gag caa act cgg ccc cag tcc agg gac gaa tac 1939 Arg Phe Lys He Val Glu Gln Thr Arg Pro Gln Ser Arg Asp Glu Tyr 600 605 610 gat att taaacgattg ctttt; cgac: g falls 1968 Asp He 615 • < 210 > 534 20 < 211 > 615 < 212 > PRT < 213 > Corynebacterium glutamicuir 1 < 400 > 534 Met Ser Ser Asn He Wing He Thr Thr Glu Pro Glu Gly Lys Asn Lys 1 5 10 15 Lys Gly Leu Lys Ser Asp Pro Phe He Phe Ser He Ser Val Gly Phe 20 25 30 He Val Val Phe Val He Ala Thr He Ala Leu Gly Glu Lys Wing Arg 35 40 45 Thr Thr Phe Be Wing He Wing Gly Trp Leu Leu Glu Asn Leu Gly Trp 25 50 55 60 TO? ± A..t- Met Tyr He Gly Gly Val Ser Leu Val Phe He Phe Leu Met Gly He 65 70 75 80 Phe Wing Being Arg Tyr Gly Arg Val Lys Leu Gly Asp Asp Asp Asp Asp 85 90 95 Pro Glu His Thr Leu He Val Trp Phe Cys Met Leu Phe Wing Gly Gly 100 105 110 Val Gly Ala Val Leu Met Phe Trp Gly Val Ala Glu Pro He Asn His 115 120 125 Wing Phe Asn Val Pro Met Wing Asn Glu Glu Ser Met Ser Glu Wing Wing 130 135 140 He Val Gln Wing Phe Wing Tyr Thr Phe Tyr His Phe Gly He His Met 145 150 155 160 Trp Val He Met Wing Wing Leu Pro Gly Leu Ser Leu Gly Tyr Phe He Tyr 165 170 175 Lys Arg Lys Leu Pro Pro Arg Leu Ser Ser Val Phe Ser Pro He Leu 180 185 190 Gly Lys His He Tyr Ser Thr Pro Gly Lys Leu He Asp Val Leu Wing 195 200 205 He Val Gly Thr Thr Phe Gly He Wing Val Ser Val Gly Leu Gly Val 210 215 220 Leu Gln Asn 10 He Wing Gly Met Asn Lys Leu Trp Ser Thr Pro Gln Val 225 230 235 240 Ser Trp Val Gln Leu Leu He He Leu He He Thr Ala Val Ala Cys 245 250 255 • Be Ser Val Ala Ser Gly Leu Asp Lys Gly He Lys Leu Leu Ser Asn 260 265 270 He Asn He Ala Met Ala Ala Ala Ala Met Phe Phe He Leu Phe Thr 275 280 285 Gly Pro Thr Leu Thr Leu Leu Arg Phe Leu Val Glu Ser Phe Gly He 290 295 300 Tyr Wing Ser Trp Met Pro Asn Leu Met Phe Trp Thr Asp Ser Phe Gln 305 310 315 320 Asp Asn Pro Gly Trp Gln Gly 15 Lys Trp Thr Val Phe Tyr Trp Wing Trp 325 330 335 Thr He Cys Trp Ser Pro Tyr Val Gly Met Phe Val Wing Arg He Ser 340 345 350 Arg Gly Arg Thr Val Arg Glu Phe He Gly Gly Val Leu Ala Leu Pro 355 360 365 Wing He Phe Gly Val Val Trp Phe Ser He Phe Gly Arg Ala Gly He 370 375 380 Glu Val Glu Leu Ser Asn Pro Gly Phe Leu Thr Gln Pro Thr Val Val • 385 390 395 400 Glu Gly Asp Val Pro Ala Ala Leu Phe Asn Val Leu Gln Glu Tyr Pro 405 410 415 20 Leu Thr Gly He Val Be Ala Phe Ala Leu Val He He Val He Phe 420 425 430 Phe He Thr Ser He Asp Ser Ala Ala Leu Val Asn Asp Met Phe Wing 435 440 445 Thr Gly Wing Glu Asn Gln Thr Pro Thr Ser Tyr Arg Val Met Trp Wing 450 455 460 Cys Thr He Gly Wing Val Wing Gly Ser Leu Leu He He Ser Pro Pro 465 470 475 480 Be Gly He Wing Thr Leu Gln Glu Val Val He He Val Wing Phe Pro 485 490 495 Phe Phe Leu Val Gln Phe Val Met Met Phe Ser Leu Leu Lys Gly Met 500 505 510 25 Ser Glu Asp Ala Ala Ala Val Arg Arg Val Gln Thr Arg Gln Trp Glu 515 520 525 Lys Thr Asp Thr Pro Glu Lys Leu Glu Glu His Ser Ser Gln Pro Ala 530 535 540 Pro Gly Tyr Asp Asp Glu Gly Asn Pro Leu Pro Met Pro Ala Leu Glu 545 550 555 560 His Asp Glu Asp Gly Asn He Val He Pro Gly Asn Val Val He Glu 565 570 575 Gly Asp Leu Gly Val Val Gly Asp Val Val Asp Asp Pro Glu Glu Wing 580 585 590 Gln Glu Met Gly Ser Arg Phe Lys He Val Glu Gln Thr Arg Pro Gln 595 600 605 Ser Arg Asp Glu Tyr Asp He 610 615 < 210 > 535 < 211 > 1968 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1945) < 223 > FRXA00298 < 400 > 535 tttagacaag ttctggttaa aattcttcat gaaggtgaga atctgggaat ttctcggtac 60 tctttcagat tcgtagttat ccactgattg gaagaatgag atg age tca aat ata 115 Met Ser Ser Asn He 1 5 gct ate acg acc gag ect gaa ggg aaa aat aaaaag ggt etc aaa tca 163 Ala He Thr Thr Glu Pro Glu Gly Lys Asn Lys Lys Gly Leu Lys Ser 10 15 20 gac ccg ttc att ttt tcc att tet gtc ggt ttt ate gtg gtg ttt gtc 211 Asp Pro Phe He Phe Ser He Ser Val Gly Phe He Val Val Phe Val 25 30 35 ate gcc here att gcg cta ggc gag aaa gct cga here acc ttt gcg 259 He Ala Thr He Ala Leu Gly Glu Lys Ala Arg Thr Thr Phe Ser Wing 40 45 50 att gcc ggc tgg etc tta gaa aat tta ggg tgg atg tat ate ggg ggt 307 He Wing Wing Gly Trp Leu Leu Glu Asn Leu Gly Trp Met Tyr He Gly Gly 55 60 65 gtc tcc ttg gtt ttc att ttc etc atg ggt ate ttt gcg tcc cgg tat 355 Val Ser Leu Val Phe He Phe Leu Met Gly He Phe Wing Arg Tyr 70 75 80 85 ggc cgg gta aaa ctt ggt gat gac gat gat gac ccc gag drops acc tab 403 Gly Arg Val Lys Leu Gly Asp Asp Asp Asp Asp Pro Glu His Thr L eu 90 95 100 ate gtg tgg ttc tgt atg ctt ttt gct ggc ggt gtc ggt gca gtc tta 451 He Val Trp Phe Cys Met Leu Phe Wing Gly Gly Val Gly Wing Val Leu 105 110 115 atg ttt tgg ggt gtt gcc gaa ccg att aac falls gcg ttc aac gtg cca 499 Met Phe Trp Gly Val Wing Glu Pro He Asn His Wing Phe Asn Val Pro 120 125 130 atg gct aat gaa gaa tcc atg agt gaa gcc gca att gtg cag gct ttt 547 Met Wing Asn Glu Glu Ser Met Ser Glu Wing Wing He Val Gln Wing Phe 135 140 145 gct tat act ttc tat falls ttc ggt att falls atg tgg gta ate atg gca 595 ; - ^ - .. t. ^.-Jg¿i Í: < Wing Tyr Thr Phe Tyr His Phe Gly He His Met Trp Val He Met Wing 150 155 160 _ 165 etc cca gga tta tca ttg gga tac ttt att tac aaa cgt aag cta ect 643 Leu Pro Gly Leu Ser Leu Gly Tyr Phe He Tyr Lys Arg Lys Leu Pro 170 175 180 ccc cgt cta tcc tet gtg ttt tet ccg ate ttg ggt aag falls att tat 691 Pro Arg Leu Ser Ser Val Phe Ser Pro He Leu Gly Lys His He Tyr 185 190 195 tcc here ccc ggc aag etc ate gat gta ctg gcc ate gta ggc acc acg 739 Ser Thr Pro Gly Lys Leu He Asp Val Leu Wing He Val Gly Thr Thr 200 205 210 ttt ggt att gct gtg tca gta gtt ctt ggt gtg ctg caa ate aat gca 787 Phe Gly He Ala Val Ser Val Gly Leu Gly Val Leu Gln He Asn Ala 215 220 225 ggt atg aac aaa cta tgg age acc ccg caa gta tcg tgg gtt cag ctt 835 Gly Met Asn Lys Leu Trp Ser Thr Pro Gln Val Ser Trp Val Gln Leu 230 235 240 245 ttg ate ate ttg ate ate gcg gtt gt tgt att tcc gtt gct tcc 883 Leu He He Leu He He Thr Ala Val Ala Cys He Ser Val Ala Ser 250 255 260 ggt ttg gat aag ggc att aag tta ctg tcc aac att to at att gca atg 931 10 Gly Leu Asp Lys Gly He Lys Leu Leu Ser Asn He Asn He Wing Met 265 270 275 gcc gtt gcg ttg atg ttc ttc ate ttg ttc act ggt cca acc etc here 979 • Wing Val Ala Leu Met Phe Phe He Leu Phe Thr Gly Pro Thr Leu Thr 280 285 290 ttg ctg cgc ttt etc gta gaa tcc ttc gga ate tat gca tcc tgg atg 1027 Leu Leu Arg Phe Leu Val Glu Ser Phe Gly He Tyr Ala Ser Trp Met 295 300 305 ect aat ctg atg ttt tgg act gac tet ttc caa gat aac cca ggc tgg 1075 Pro Asn Leu Met Phe Trp Thr Asp Ser Phe Gln Asp Asn Pro Gly Trp 310 315 320 325 cag ggc aaa tgg acg gtg ttc tat tgg gca tgg act att tgt tgg tcg 1123 15 Gln Gly Lys Trp Thr Val Phe Tyr Trp Wing Trp Thr He Cys Trp Ser 330 335 340 cca tat gtc ggc atg ttc gtg gcg cgt att tcg cgt gga cgt acc gtc 1171 Pro Tyr Val Gly Met Phe Val Wing Arg He Ser Arg Gly Arg Thr Val 345 350 355 cgt gaa ttt ate ggt ggg gtt cta gct ctg cca gcg ate ttt ggc gta 1219 Arg Glu Phe He Gly Gly Val Leu Ala Leu Pro Wing He Phe Gly Val 360 365 370 • gtt tgg ttc tet ate ttt ggt cgt gca ggc ate gaa gtg gaa ctg agt 1267 Val Trp Phe Ser He Phe Gly Arg Ala Gly He Glu Val Glu Leu Ser 375 380 385 20 aac cca ggt ttc ttg acc cag cca act gtt gtt gaa ggt gac gtg cca 1315 Asn Pro Gly Phe Leu Thr Gln Pro Thr Val Val Glu Gly Asp Val Pro 390 395 400 405 gca gcg ctt ttt aat gtg ctg caa gag tat ccg ctg act gga att gtc 1363 Wing Ala Leu Phe Asn Val Leu Gln Glu Tyr Pro Leu Thr Gly He Val 410 415 420 ccc gcg ttt gca ctt gta att att gtg att ttc ttt ate acc tcc ate 1411 Be Ala Phe Ala Leu Val He He Val He Phe Phe He Thr Ser He 425 430 435 gat tcc gca gcg cta gtt aac gat atg t tc gct acc ggt gca gaa aat 1459 Asp Ser Ala Ala Leu Val Asn Asp Met Phe Ala Thr Gly Ala Glu Asn 440 445 450 25 caa here ccg act agt tac cgc gtg atg tgg gcc tgc acc att ggg gcg 1507 Gln Thr Pro Thr Ser Tyr Arg Val Met Trp Wing Cys Thr He Gly Wing 455 460 465 gtc gca ggt tcc ttg ctg ate att ccc tcc tet ggt att gcc acg 1555 Val Ala Gly Ser Leu Leu He He Ser Pro Pro Ser Gly He Ala Thr 470 475 480 485 ctg caa gaa gtg gtt ate ate gtg gct tcc cca ttc ttc etc gtg caa 1603 Leu Gln Glu Val Val He He Val Val Phe Pro Phe Phe Leu Val Gln 490 495 500 ttt gtc atg att ttt tt ttg ctt aaa ggc atg agt gaa gat gct gct 1651 Phe Val Met Met Phe Ser Leu Leu Lys Gly Met Ser Glu Asp Wing Ala 505 510 515 gcg gtt cgt cgt gtg cag act cgt cag tgg gaa aag act cca 1699 Wing Val Arg Arg Val Gln Thr Arg Gln Trp Glu Lys Thr Asp Thr Pro 520 525 530 gaa aaa ctt gaa gag cat tcg tcc caa cca gcc ccg ggc tat gat gac 1747 Glu Lys Leu Glu Glu His Ser Ser Gln Pro Wing Pro Gly Tyr Asp Asp 535 540 545 gag ggc aac ccc ttg cca atg ect gcc etc gaa cat gat gag gac ggt 1795 Glu Gly Asn Pro Leu Pro Met Pro Ala Leu Glu His Asp Glu Asp Gly 550 555 560 565 10 aac att gtt ate cca ggc aac gta gtc att gaa ggt gat ctt ggg gta 1843 Asn He Val He Pro Gly Asn Val Val He Glu Gly Asp Leu Gly Val 570 575 580 gtt ggt gat gtg gtc gac gat ect gag gaa gcc caa gag atg ggg tet 1891 • Val Gly Asp Val Val Asp Asp Pro Glu Glu Wing Gln Glu Met Gly Ser 585 590 595 cgt ttt aag ate gtc gag caa act cgg ccc cag tcc agg gac gaa tac 1939 Arg Phe Lys He Val Glu Gln Thr Arg Pro Gln Ser Arg Asp Glu Tyr 600 605 610 gat att taaacgattg cttttcgacg falls 1968 Asp He 615 15 < 210 > 536 < 211 > 615 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 536 Met Ser Ser Asn He Wing He Thr Thr Glu Pro Glu Gly Lys Asn Lys 1 5 10 15 • Lys Gly Leu Lys Ser Asp Pro Phe He Phe Ser be Ser Val Gly Phe 20 25 30 He Val Val Phe Val He Ala Thr He Wing Leu Gly Glu Lys Wing Arg 20 35 40 45 Thr Thr Phe Wing Wing Wing Wing Gly Trp Leu Leu Glu Asn Leu Gly Trp 50 55 60 Met Tyr He Gly Gly Val Ser Leu Val Phe He Phe Leu Met Gly He 65 70 75 80 Phe Wing Being Arg Tyr Gly Arg Val Lys Leu Gly Asp Asp Asp Asp Asp 85 90 95 Pro Glu His Thr Leu He Val Trp Phe Cys Met Leu Phe Wing Gly Gly 100 105 110 Val Gly Ala Val Leu Met Phe Trp Gly Val Ala Glu Pro He Asn His 115 120 125 Ala Phe Asn Val Pro Met Ala Asn Glu Glu Ser Met Ser Glu Ala Ala 25 130 135 140 i ^ Aa, j He Val Gln Ala Phe Ala Tyr Thr Phe Tyr His Phe Gly He His Met 145 150 155 160 Trp Val He Met Ala Leu Pro Gly Leu Ser Leu Gly Tyr Phe He Tyr 165 170 175 Lys Arg Lys Leu Pro Pro Arg Leu Ser Ser Val Phe Ser Pro He Leu 180 185 190 Gly Lys His He Tyr Ser Thr Pro Gly Lys Leu He Asp Val Leu Wing 195 200 205 He Val Gly Thr Thr Phe Gly He Wing Val Ser Val Gly Leu Gly Val • 210 215 220 Leu Gln He Asn Wing Gly Met Asn Lys Leu Trp Ser Thr Pro Gln Val 225 230 235 240 Ser Trp Val Gln Leu Leu He He Leu He He Thr Ala Val Ala Cys 245 250 255 He Ser Val Val Ser Gly Leu Asp Lys Gly He Lys Leu Leu Ser Asn 260 265 270 He Asn He Wing Met Wing Val Wing Leu Met Phe Phe He Leu Phe Thr 275 280 285 Gly Pro Thr Leu Thr Leu Leu Arg Phe Leu Val Glu Ser Phe Gly He 290 295 300 Tyr Wing Ser Trp Met Pro Asn Leu Met Phe Trp Thr Asp Ser Phe Gln 10 305 310 315 320 Asp Asn Pro Gly Trp Gln Gly Lys Trp Thr Val Phe Tyr Trp Wing Trp 325 330 335 • Thr He Cys Trp Ser Pro Tyr Val Gly Met Phe Val Wing Arg He Ser 340 345 350 Arg Gly Arg Thr Val Arg Glu Phe He Gly Gly Val Leu Ala Leu Pro 355 360 365 Wing He Phe Gly Val Val Trp Phe Ser He Phe Gly Arg Wing Gly He 370 375 380 Glu Val Glu Leu Ser Asn Pro Gly Phe Leu Thr Gln Pro Thr Val Val 385 390 395 400 Glu Gly Asp 15 Val Pro Ala Ala Leu Phe Asn Val Leu Gln Glu Tyr Pro 405 410 415 Leu Thr Gly He Val Ser Wing Phe Wing Leu Val He He Val Phe 420 425 430 Phe He Thr Ser He Asp Ser Wing Wing Leu Val Asn Asp Met Phe Wing 435 440 445 Thr Gly Wing Glu Asn Gln Thr Pro Thr Ser Tyr Arg Val Met T rp Wing 450 455 460 Cys Thr He Gly Wing Val Wing Gly Ser Leu Leu He He Ser Ser Pro • 465 470 475 480 Ser Gly He Wing Thr Leu Gln Glu Val Val He He Val Wing Phe Pro 485 490 495 20 Phe Phe Leu Val Gln Phe Val Met Met Phe Ser Leq Leu Lys Gly Met 500 505 510 Ser Glu Asp Wing Wing Val Arg Arg Val Gln Thr Arg Gln Trp Glu 515 520 525 Lys Thr Asp Thr Pro Glu Lys Leu Glu Glu His Ser Ser Gln Pro Wing 530 535 540 Pro Gly Tyr Asp Asp Glu Asn Pro Leu Pro Met Pro Ala Leu Glu 545 550 555 560 His Asp Glu Asp Gly Asn He Val He Pro Gly Asn Val Val He Glu 565 570 575 Gly Asp Leu Gly Val Val Gly Asp Val Val Asp Asp Pro Glu Glu Wing 580 585 590 25 Gln Glu Met Gly Ser Arg Phe Lys He Val Glu Gln Thr Arg Pro Gln *, A-1 £ sa. & . ^. jt »» á - i¿ JL 595 600 605 Ser Arg Asp Glu Tyr Asp He 610 615 < 210 > 537 < 211 > 576 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (553) < 223 > RXA00596 < 400 > 537 ccgccaccga cggcctcttg aacaccgatg cat; aaccccaaaaccaa ggctgtgctc < ggtgaaaatg 60 ccatcggagt gccaagccct agctaccagg gagiggaaaaaaccttaa atg ctt aac gcc ctg 115 Met Leu Asn Ala Leu 1 5 aaa ttc ate cca tgg ctg ate ggc cag att ttc etc tet ggc ttc age 163 10 Lys Phe He Pro Trp Leu He Gly Gln He Phe Leu Ser Gly Phe Ser 10 15 20 gtg ate acc gct gcg gta aaa aag gac acc ggc ttc aac ccc gtt gtt 211 Val He Thr Wing Wing Val Lys Lys Asp Thr Gly Phe Asn Pro Val Val 25 30 35 • ate cgc tac cca ctt cga gtg acc acg gac ttc cag ate gca gcc ctg 259 He Arg Tyr Pro Leu Arg Val Thr Thr Asp Phe Gln He Ala Ala Leu 40 45 50 tca acg tgc ate acc gcg act ect tcc acc ctg tcc ctt ggc cta cgc 307 Ser Thr Cys He Thr Ala Thr Pro Ser Thr Leu Ser Leu Gly Leu Arg 55 60 65 gaa ccc cgc aag ccc ggc gac ccc acc att ttg ctg ate caa gca gtg 355 15 Glu Pro Arg Lys Pro Gly Asp Pro Thr He Leu Leu He Gln Ala Val 70 75 80 85 ttt ggt tcc gat cca gta gaa gtt ttt gaa tcc ate gcc gat atg gaa 403 Phe Gly Ser Asp Pro Val Glu Val Phe Glu Ser He Wing Asp Met Glu 90 95 100 caa cgc etc gt c ect tcg gtc gct tca att gac drops ggc gtc cca ggc 451 Gln Arg Leu Val Pro Ser Val Ala Ser He Asp His Gly Val Pro Gly 105 110 115 caa ggc ect tac aag gag ate cgc ccc age gat gct gag tgg cca agt 499 • Gln Gly Pro Tyr Lys Glu He Arg Pro Ser Asp Wing Glu Trp Pro Ser 120 125 130 cgc gag ate gct gac acc gcc caa aac acc gtc age caa gac aag agg 547 20 Arg Glu He Ala Asp Thr Ala Gln Asn Thr Val Ser Gln Asp Lys Arg 135 140 145 gag ttt taaaacaaca tgactgcttt tgg 576 Glu Phe 150 < 210 > 538 < 211 > 151 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 538 25 Met Leu Asn Ala Leu Lys Phe He Pro Trp Leu He Gly Gln He Phe ». ^^ '^ iiá.iiA, 1 5 10 15 Leu Ser Gly Phe Ser Val He Thr Wing Wing Val Lys Lys Asp Thr Gly 20 25 30 Phe Asn Pro Val Val He Arg Tyr Pro Leu Arg Val Thr Thr Asp Phe 35 40 45 Gln He Ala Wing Leu Being Thr Cys He Thr Wing Thr Pro Being Thr Leu 50 55 60 Being Leu Gly Leu Arg Glu Pro Arg Lys Pro Gly Asp Pro Thr He Leu 65 70 75 80 • Leu He Gln Wing Val Phe Gly Ser Asp Pro Val Glu Val Phe Glu Ser 85 90 95 He Wing Asp Met Glu Gln Arg Leu Val Pro Ser Val Wing Ser He Asp 100 105 110 His Gly Val Pro Gly Gln Gly Pro Tyr Lys Glu He Arg Pro Ser Asp 115 120 125 W Glu Trp Pro Ser Arg Glu He Wing Asp Thr Wing Gln Asn Thr Val 130 135 140 Ser Gln Asp Lys Arg Glu Phe 145 150 10 < 210 > 539 < 211 > 750 < 212 > DNA < 213 > Corynebacterium glutamicum • < 220 > < 221 > CDS < 222 > (101) .. (727) < 223 > RXA02364 < 400 > 539 gegaaagtat < rtaaggtcgt ttgattggtt tactaccccc gaagtggggg 1itattggcag 60 15 catt: gagcac < -aaatgagcg tgatccggga tcaggatctg atg gag cca ctg ttc 115 Met Glu Pro Leu Phe 1 5 caa agt ctt gcg gaa tcg gac aat att tet gtc att ggt gga ttt acc 163 Gln Ser Leu Wing Glu Being Asp Asn He Ser Val He Gly Gly Phe Thr 10 15 20 caa ggc acc cga aat ctg tac acc ac t gat gcg ccg gtg aaa aga ccc 211 Gln Gly Thr Arg Asn Leu Tyr Thr Thr Asp Wing Pro Val Lys Arg Pro 25 30 35 • gct gac ctg gct gag aag aag att cgc gtc cag gaa tcc gcc atg cae 259 Wing Asp Leu Wing Gly Lys Lys He Arg Val Gln Glu Wing Wing Met His 40 45 50 20 ate cgc atg att gaa etc atg ggt ggc tcg gca acc ccg ttg act tac 307 He Arg Met He Glu Leu Met Gly Gly Be Wing Thr Pro Leu Thr Tyr 55 60 65 ggc gag gta tat acc gcg atg cag tet ggt gtg ctg gat ggc gcg gaa 355 Gly Glu Val Tyr Thr Ala Met Gln Ser Gly Val Leu Asp Gly Ala Glu 70 75 80 85 aat aac gag ate agt tac gtt acc aac falls ttc gag gtt gct cgc 403 Asn Asn Glu He Ser Tyr Val Thr Gln Asn His Phe Glu Val Wing Arg 90 95 100 tac aac age aac acc aat falls ctt gtc ggt ttg gat tac atg gtc atg 451 Tyr Asn Ser Asn Thr Asn His Leu Val Gly Leu Asp Tyr Met Val Met 105 110 115 25 cga falls gat ctg ctt gac gcc atg age gag cca gac cgt gaa ttg ttc 499 Arg His Asp Leu Leu Asp Ala Met Ser Glu Pro Asp Arg Glu Leu Phe 120 125 130 ctg gaa gaga tgg gac gcc gcg atg act gag falls acg gat ctg tgg aac 547 Leu Glu Glu Trp Asp Ala Ala Met Thr Glu His Thr Asp Leu Trp Asn 135 140 145 here gaa act gat gcc gtt att gaa aag gcg aaa gct ggg gga gcg gag 595 Thr Glu Thr Asp Ala Val He Glu Lys Ala Lys Ala Gly Gly Ala Glu 150 155 160 165 ttc gtt gag gtg gat gcg caa gca ttt acc gat gca ctg gct ccc ate 643 Phe Val Glu Val Asp Ala Gln Ala Phe Thr Asp Ala Leu Ala Pro He 170 175 180 aaa gac gaa ttc ttg acc tca gaa tcc cag cgt gaa etc tac gaa gca 691 Lys Asp Glu Phe Leu Thr Ser Glu Phe Gln Arg Glu Leu Tyr Glu Wing 185 190 195 gtg cgc gcc gct gat act tca gga ggt gcg gca tca tgatgaattt 737 Val Arg Wing Wing Asp Thr Ser Gly Gly Wing Wing Ser 200 205 taagtccatc gtg 750 < 210 > 540 < 211 > 209 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 540 Met Glu Pro Leu Phe Gln Ser Leu Ala Glu Ser Asp Asn He Ser Val 1 5 10 15 He Gly Gly Phe Thr Gln Gly Thr Arg Asn Leu Tyr Thr Thr Asp Wing 20 25 30 Pro Val Lys Arg Pro Wing Asp Leu Wing Gly Lys Lys He Arg Val Gln 35 40 45 Glu Ser Wing Met His He Arg Met He Glu Leu Met Gly Gly Be Ala 50 55 60 Thr Pro Leu Thr Tyr Gly Val Tyr Thr Ala Met Gln Ser Gly Val 65 70 75 80 Leu Asp Gly Wing Glu Asn Asn Glu He Ser Tyr Val Thr Gln Asn His 85 90 95 Phe Glu Val Wing Arg Tyr Asn Ser Asn Thr Asn His Leu Val Gly Leu 100 105 110 Asp Tyr Met Val Met Arg His Asp Leu Leu Asp Ala Met Ser Glu Pro 115 120 125 Asp Arg Glu Leu Phe Leu Glu Glu Trp Asp Ala Ala Met Thr Glu His 130 135 140 Thr Asp Leu Trp Asn Thr Glu Thr Asp Ala Val He Glu Lys Ala Lys 145 150 155 160 Wing Gly Gly Wing Glu Wing Val Glu Wing Asp Wing Gln Wing Phe Thr Asp 165 170 175 Wing Leu Wing Pro He Lys Asp Glu Phe Leu Thr Ser Glu Phe Gln Arg 180 185 190 Glu Leu Tyr Glu Wing Val Arg Wing Wing Asp Thr Ser Gly Gly Ala Ala 195 200 205 Ser < 210 > 541 < 211 > 888 < 212 > DNA < 213 > Corynebacterium glutamicum Ü ^ a ^ Aa < 220 > < 221 > CDS < 222 > (101) .. (865) < 223 > RXN01411 < 400 > 541 cttatcgacg -tccccatccc cctcgccaat gcttcggcga ggggttctat ttattgtgtg 60 tgctagcctt -ttcgcaatcg ttcagcccgc cccgacgtca atg ttg gga gtg ggc 115 Met Leu Gly Val Gly 1 5 tgg cgc att cca ttc ctg atg gcc gtg cca cta ggg ctt ate ggc tgg 163 Trp Arg He Pro Phe Leu Met Wing Val Pro Leu Gly Leu He Gly Trp 10 15 20 tgg ate cgc acc ggt gcc cag gaa aat gta cgc ccc gcc tcc gaa cgc 211 Trp He Arg Thr Gly Wing Gln Glu Asn Val Arg Pro Wing Ser Glu Arg 25 30 35 ccc gaa gct ect att aag cag gca ttg cgt act gag tgg aag atg atg 259 Pro Glu Ala Pro He Lys Gln Ala Leu Arg Thr Glu Trp Lys Met Met 40 45 50 ttg cgg gta ggt ggc ttt ate tet tgc acc ggt ctg age ttc tac att 307 Leu Arg Val Gly Gly Phe He Ser Cys Thr Gly Leu Ser Phe Tyr He 55 60 65 ttc ac ac tac atg acc act ttc ctc cgc age acc gtc gga ctg gag 355 Phe Thr Thr Tyr Met Thr Thr Phe Leu Arg Ser Thr Val Gly Leu Glu 70 75 80 85 ggc acg tta gtg ctg gct gga aac ate ate gct etc age atg gca gca 403 Gly Thr Leu Val Leu Wing Gly Asn He He Wing L eu Ser Ala Wing Wing 90 95 100 att gtg gcc cca ttt gtt ggc cgc gca att gat aaa ttc ccc cgc cgg 451 He Val Wing Pro Phe Val Gly Arg Wing He Asp Lys Phe Pro Arg Arg 105 110 115 aac ate atg gct ttc gct acc tta age here gta att atg gcg ate ccg 499 Asn He Met Ala Phe Ala Thr Leu Ser Thr Val He Met Ala He Pro 120 125 130 gcc tac ate att gca ggt caa ggt act ttg act gct tet ttg att gcg 547 Wing Tyr He He Wing Gly Gln Gly Thr Leu Thr Ala Ser Leu He Wing 135 140 145 cag gta atg ctt gga ate ggc gcg gtt acc gct aac tgc gtt acc tca 595 Gln Val Met Leu Gly He Gly Wing Val Thr Wing Asn Cys Val Thr Ser 150 155 160 165 gta atg atg gcc gag gtc ttc caa gag gtc acc cgc ggt act tcc gcc 643 Val Met Met Wing Glu Val Phe Gln Glu Val Thr Arg Gly Thr Ser Wing 170 175 180 ggc att acc tac aac gtc act tac gca ate ttc ggc ggc tcg gct cca 691 Gly He Thr Tyr Asn Val Thr Tyr Wing He Phe Gly Gly Ser Wing Pro 185 190 195 ttt ate tcc tc gtc gtc acc tcc tgg acc ggc age ccg ctg gcc ect 739 Phe He Ser Thr Ala Leu V to Be Trp Thr Gly Pro Pro Leu Wing Pro 200 205 210 gcg gta tac atg ate ate gcg etc ttc gcc ttc acc gcg tcc cgc 787 Wing Val Tyr Met He He He Wing Wing Leu Phe Wing Phe Thr Wing Being Arg 215 220 225 ttc att ect gaa acc tcc cca gtt ttt gtc acc gca acc ccg gcc att 835 Phe He Pro Glu Thr Ser Pro Val Phe Val Thr Ala Thr Pro Ala He 230 235 240 245 aag gca cca aag gtg ctg gtc aac ccg ggt taaaccacgc ttttcgacga 885 Lys Wing Pro Lys Val Leu Val Asn Pro Gly 250 255 aaa < 210 > 542 < 211 > 255 < 212 > PRT < 213 > Corynebacterium glutamicum • < 400 > 542 Met Leu Gly Val Gly Trp Arg He Pro Phe Leu Met Wing Val Pro Leu 1 5 10 15 Gly Leu He Gly Trp Trp He Arg Thr Gly Wing Gln Glu Asn Val Arg 20 25 30 Pro Wing Ser Glu Arg Pro Glu Wing Pro He Lys Gln Wing Leu Arg Thr 35 40 45 Glu Trp Lys Met Met Leu Arg Val Gly Gly Phe He Ser Cys Thr Gly 50 55 60 Leu Ser Phe Tyr He Phe Thr Thr Tyr Met Thr Thr Phe Leu Arg Ser 65 70 75 80 10 Thr Val Gly Leu Glu Gly Thr Leu Val Leu Wing Gly Asn He He Wing 85 90 95 Leu Ser Met Wing Wing He Val Wing Pro Phe Val Gly Arg Wing He Asp 100 105 110 Lys Phe Pro Arg Arg Asn He Met Wing Phe Wing Thr Leu Be Thr Val • 115 120 125 He Met Wing He Pro Wing Tyr He He Wing Gly Gln Gly Thr Leu Thr 130 135 140 Wing Being Leu He Wing Gln Val Met Leu Gly He Gly Wing Val Thr Wing 145 150 155 160 Asn Cys Val Thr Ser Val Met Met Wing Glu Val Phe Gln Glu Val Thr 165 170 175 15 Arg Gly Thr Ser Wing Gly He Thr Tyr Asn Val Thr Tyr Wing He Phe 180 185 190 Gly Gly Ser Wing Pro Phe He Ser Thr Wing Leu Val Ser Trp Thr Gly 195 200 205 S er Pro Leu Ala Pro Ala Val Tyr Met He He He Wing Wing Leu Phe Wing 210 215 220 Phe Thr Wing Wing Arg Phe He Pro Glu Thr Ser Pro Val Phe Val Thr 225 230 235 240 Wing Thr Pro Wing He Lys Wing Pro Lys Val Leu Val Asn Pro Gly 245 250 255 • < 210 > 543 20 < 211 > 1058 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (1035) < 223 > RXN00960 < 400 > 543 atg gct cgg cat tgt tgc age aat cgc tac gcg tcc acc gtc ttc tcc 48 Met Wing Arg His Cys Cys Ser Asn Arg Tyr Wing Ser Thr Val Phe Ser 25 1 5 10 15 ggt ctg ate gcc tac gga gca gcc ccc gcg etc tac cca tgg ctg ctg 96 Gly Leu He Wing Tyr Gly Wing Being Gln Wing Leu Tyr Pro Trp Leu Leu 20 25 30 aaa gac falls caa age gtc acc gaa ate gac ctt gat gca ggt gcc etc 144 Lys Asp His Gln Ser Val Thr Glu He Asp Leu Asp Ala Gly Ala Leu 35 40 45 cag ccc tac tc aac ate gag atg cca cca cca ttt gaa gtg atg acc 192 Gln Pro Tyr Phe Asn He Glu Met Pro Pro Pro Phe Glu Val Met Thr 50 55 60 • gca ctg ctg ctg gca ttc tgc etc ggc ctg ggc atg gct gta att aaa 240 Wing Leu Leu Leu Wing Phe Cys Leu Gly Leu Gly Met Wing Val He Lys 65 70 75 80 tca gac acc ctg ttc aag gta acc cgc gaa etc gag cgc gta gtc atg 288 Be Asp Thr Leu Phe Lys Val Thr Arg Glu Leu Glu Arg Val Val Met 85 90 95 aag acc ate acc gcc ttt gtc ate cca ctg ctg cca etc ttc ate ttc 336 Lys Thr He Thr Wing Phe Val He Pro Leu Leu Pro Leu Phe He Phe 100 105 110 ggc ate ttc etc ggc atg ggc atg aac ggt ggc etc ctg gag ate atg 384 Gly He Phe Leu Gly Met Gly Met Asn Gly Gly Leu Le Glu Glu Met 10 115 120 125 tcc gcc ttt ggc aag gta ctg att gcc etc gtc gtg gga acc ctg etc 432 Be Wing Phe Gly Lys Val Leu He Leu Wing Val Val Gly Thr Leu Leu 130 135 140 • ttc cta gcc ate cag ttc att ate gct ggt gca gta tcc aag aag aac 480 Phe Leu Ala He Gln Phe He He Wing Wing Gly Wing Val Ser Lys Lys Asn 145 150 155 160 cca tgg aaa ctg ttc aaa aac atg etc ect gca tac tcc act gca ctg 528 Pro Trp Lys Leu Phe Lys Asn Met Leu Pro Wing Tyr Phe Thr Wing Leu 165 170 175 ggc act tcc tet tca gcg gca acc ate ct gtg acc tac cag cag acc 576 Gly Thr Being Ser Wing Wing Thr He Pro Val Thr Tyr Gln Gln Thr 15 180 185 190 ctg aaa aac gat gtt gat gtc aac gtc gca ggc ttt gtt gtc cca ctg 624 Leu Lys Asn Asp Val Asp Val Asn Val Wing Gly Phe Val Val Pro Leu 195 200 205 tgc gcc acc ate drops cta gct gga tcg atg atg aag ate ggc etc ttc 672 Cys Ala Thr He His Leu Ala Gly Ser Met Met Met Lys He Gly Leu Phe 210 215 220 acc ttc gct gtt gtc ttc atg tac gac atg gaa gta ggc gtc ggc etc 720 Thr Phe Wing Val Val Phe Met Tyr Asp Met Glu Val Gly Val Gly Leu 225 230 235 240 tcc ate gga ttc etc etc atg ctg ggc ate acc atg ate gcc gca cca Ser He Gly Phe Leu Leu Met Leu Gly He Thr Met He Ala Wing Pro 20 245 250 255 ggc gtt ccc ggc gga gcc ate atg gca gca acc ggc atg ctg gcc tcc 816 Gly Val Pro Gly Gly Wing Met Met Wing Wing Thr Gly Met Leu Wing Ser 260 265 270 atg etc gga ttc aac acc gaa caa gtc gcc etc atg ate gcc gct tac 864 Met Leu Gly Phe Asn Thr Glu Gln Val Ala Leu Met He Ala Ala Tyr 275 280 285 ate gcg att gac tcc ttc ggc acc gca gca aac gtc acc ggc gac ggc 912 He Wing He Asp Ser Phe Gly Thr Wing Wing Asn Val Thr Gly Asp Gly 290 295 300 gca ate gca gtc ate gtg aac aaa ttc gcc aag ggc cag ctg falls acc 960 Wing Wing Wing Val Hew Asn Lys Phe Wing Lys Gly Gln Leu His Thr 25 305 310 315 320 act tcc cca gat gaa ate gaa gac gac gac cgc gtt gcc ttc gac ate 1008 Thr Ser Pro Asp Glu He Glu Glu Asp Asp Arg Val Wing Phe Asp He 325 330 335 act cca tcg gat gtg gaa cat falls aag tagaaacccg cattttctgt 1055 Thr Pro Ser Asp Val Glu His His Lys 340 345 agt 1058 < 210 > 544 • < 211 > 345 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 544 Met Wing Arg His Cys Cys Ser Asn Arg Tyr Wing Ser Thr Val Phe Ser 1 5 10 15 Gly Leu He Wing Tyr Gly Wing Wing Gln Wing Leu Tyr Pro Trp Leu Leu 20 25 30 Lys Asp His Gln Ser Val Thr Glu He Asp Leu Asp Ala Gly Ala Leu 35 40 45 10 Gln Pro Tyr Phe Asn He Glu Met Pro Pro Pro Phe Glu Val Met Thr 50 55 60 Wing Leu Leu Leu Wing Phe Cys Leu Gly Leu Gly Met Wing Val He Lys 65 70 75 80 • Being Asp Thr Leu Phe Lys Val Thr Arg Glu Leu Glu Arg Val Val Met 85 90 95 Lys Thr He Thr Wing Phe Val He Pro Leu Leu Pro Leu Phe He Phe 100 105 110 Gly He Phe Leu Gly Met Gly Met Asn Gly Gly Leu Leu Glu He Met 115 120 125 Be Wing Phe Gly Lys Val Leu He Leu Wing Val Val Gly Thr Leu Leu 130 135 140 15 Phe Leu Wing He Gln Phe He Wing Wing Gly Wing Val Ser Lys Lys Asn 145 150 155 160 Pro Trp Lys Leu Phe Lys Asn Met Leu Pro Wing Tyr Phe Thr Wing Leu 165 170 175 Gly Thr Ser Ser Be Wing Wing Thr He Pro Val Thr Tyr Gln Gln Thr 180 185 190 Leu Lys Asn Asp Val Asp Val Asn Val Wing Ala Gly Phe Val Val Pro Leu 195 200 205 Cys Wing Thr He His Leu Wing Gly Ser Met Met Lys He Gly Leu Phe • 210 215 220 Thr Phe Wing Val Val Phe Met Tyr Asp Met Glu Val Gly Val Gly Leu 225 230 235 240 20 Ser He Gly Phe Leu Leu Met Leu Gly He Thr Met He Wing Wing Pro 245 250 255 Gly Val Pro Gly Gly Wing He Met Wing Wing Thr Gly Met Leu Wing Ser 260 265 270 Met Leu Gly Phe Asn Thr Glu Gln Val Wing Leu Met He Wing Wing Tyr 275 280 285 He Wing He Asp Ser Phe Gly Thr Wing Wing Asn Val Thr Gly Asp Gly 290 295 300 Wing Wing Val Hew Val Asn Lys Phe Wing Lys Gly Gln Leu His Thr 305 310 315 320 Thr Ser Pro Asp Glu He Glu Glu Asp Asp Arg Val Wing Phe Asp He 325 330 335 25 Thr Pro Ser Asp Val Glu His His Lys auuááííiim mk ii? áiliiiíi .í .í .4, _. .i ..v **** A,. ^. ^. .-j * ~ .. * ~ M iátitÉatu? My * tjaur. «t ~ ?? * ._. z,? .--. ,. . ".. & .-. " "._, -4 ,. _ ». .ia j.it - Án 340 345 < 210 > 545 < 211 > 1118 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (1095) < 223 > RXN02447 < 400 > 545 here gta gtt ccg gtg tac etc gct gaa etc gca cca cta gaa aattee ccggcc 48 Thr Val Val Pro Val Tyr Leu Ala Glu Leu Ala Pro Leu Glu He Arg 1 5 10 15 ggc tcc ctg acc ggc cga aac gag ctt gct ate gtc acc ggc ccaagg ccttgg 96 Gly Ser Leu Thr Gly Arg Asn Glu Leu Wing He Val Thr Gly Gln Leu 20 25 30 ctt gcc ttc gtg ate aac gcg ctt ate gcc gtc acc cta cae gga gtt 144 10 Leu Ala Phe Val He Asn Ala Leu He Ala Val Thr Leu His Gly Val 35 40 45 att gat gga ate tgg cgc ate atg ttc gcc gtc tgt gcc etc ect gcc 192 He Asp Gly He Trp Arg He Met Phe Ala Val Cys Ala Leu Pro Wing • 50 55 60 gtc gcc etc ttc etc ggc atg ctg cgg atg ccg gaa tca cca cgc tgg 240 Val Wing Leu Phe Leu Gly Met Leu Arg Met Pro Glu Ser Pro Arg Trp 65 70 75 80 ctg gtc aac cag ggg cgt tac gac gac gcc cgc cgc gtc atg gag acc 288 Leu Val Asn Gln Gly Arg Tyr Asp Asp Ala Arg Arg Val Met Glu Thr 85 90 95 gtc cgt acc ect gag cgt gcg aaa gcc gaa atg gat gaa ate ate gcg 336 15 Val Arg Thr Pro Glu Arg Ala Lys Ala Glu Met Asp Glu He He Ala 100 105 110 gtg falls tet gaa aac aat gcg gca ctt ect ggt gtt aag cag tet tcg 384 Val His Ser Glu Asn Asn Ala Ala Leu Pro Gly Val Lys Gln Ser Ser 115 120 125 ggc cag gct tca ggc cag gtt tet age aag falls acc falls aattgg ttcccc aattee 432 Gly Gln Ala Ser Gly Gln Val Ser Ser Lys His Thr His Met Ser He 130 135 140 ggc gaa gtc etc age aac aaa tgg ctg gtt cgt ctg etc aattee ggcccc ggggcc 480 Gly Glu Val Leu Ser Asn Lys Trp Leu Val Arg Leu Leu H Hee Wing Gly 145 150 155 160 ate ggt gtt gtt gtt gcc cag cag etc acc ggc ate aac ggcccc aattee aattte 528 20 He Gly Val Ala Ala Ala Gln Gln Leu Thr Gly He Asn A Allaa H Hee Met 165 170 175 tac tac gga acc cgc gtc etc gag gaa tcc ggc atg age gca gaa atg 576 Tyr Tyr Gly Thr Arg Val Leu Glu Glu Ser Gly Met Be Ala Glu Met 180 185 190 gct gtt gtt gcc aac att gct ttc ggt gcc gtt gcc gtc ate ggt gga 624 Wing Val Val Wing Asn He Wing Phe Gly Wing Val Wing Val He Gly Gly 195 200 205 ctg ate gca ctg cgc aac atg gac cgc ctg gat cgc cgc acc action ttc 672 Leu He Wing Leu Arg Asn Met Asp Arg Leu Asp Arg Thr Thr Phe 210 215 220 ate ate ggc ctg tca ctg acc acc ttc falls ctt ttg ate gca gct gct 720 25 He He Gly Leu Ser Leu Thr Thr Thr Phe His Leu Leu He Ala Wing 225 230 235 240 gcc ggc act etc ctt cca gaa ggt aac tcc att cga cca ttc gcc ate 768 Wing Gly Thr Leu Leu Pro Glu Gly Asn Be He Arg Pro Phe Wing He 245 250 255 atg ate ctt gtt gtt ggg ttc gtg etc tcc atg cag act ttc etc. aac 816 Met He Leu Val Val Gly Phe Val Leu Ser Met Gln Thr Phe Leu Asn 260 265 270 gtt gca gtg tgg gtg tgg ctg gcg gaa ate ttc cca gtc cga atg aag 864 Val Wing Val Trp Val Trp Leu Wing Glu He Phe Pro Val Arg Met Lys • 275 280 285 ggt ate ggc attgc att tcg gta ttc tgc ggt tgg ggc ate aat ggc 912 Gly He Gly Thr Gly He Ser Val Phe Cys Gly Trp Gly He Asn Gly 290 295 300 gtc cta gcg ttg ttc tcc cca gca ctg gtc tcc ggc gtg gct ate acc 960 Val Leu Ala Leu Phe Phe Pro Ala Leu Val Ser Gly Val Gly He Thr 305 310 315 320 ttc tcc ttc ctt ate ttc gca gtc gtc gga gtc att gcc ctg gcg ttc 1008 Phe Ser Phe Leu He Phe Wing Val Val Gly Val He Wing Leu Wing Phe 325 330 335 gtc acc aag ttt gtt ect gaa acc cgt ggc cgc tca ctt gaa gaa etc 1056 Val Thr Lys Phe Val Pro Glu Thr Arg Gly Arg Ser Leu Glu Glu Leu 10 340 345 350 gat falls gca gca ttc acc ggc cag ate ttc aag aag gct taaaccccct 1105 Asp His Wing Wing Phe Thr Gly Gln He Phe Lys Lys Wing • 355 360 365 ccgatctctt tgg 1118 < 210 > 546 < 211 > 365 < 212 > PRT < 213 > Corynebacterium glutamicum 15 < 400 > 546 Thr Val Val Pro Val Tyr Leu Ala Glu Leu Ala Pro Leu Glu He Arg 1 5 10 15 Gly Ser Leu Thr Gly Arg Asn Glu Leu Wing He Val Thr Gly Gln Leu 20 25 30 Leu Ala Phe Val He Asn Ala Leu He Ala Val Thr Leu His Gly Val 35 40 45 He Asp Gly He Trp Arg He Met Phe Wing Val Cys Ala Leu Pro Wing 50 55 60 • Val Ala Leu Phe Leu Gly Met Leu Arg Met Pro Glu Ser Pro Arg Trp 65 70 75 80 Leu Val Asn Gln Gly Arg Tyr Asp Asp Wing Arg Arg Val Met Glu Thr 20 85 90 95 Val Arg Thr Pro Glu Arg Wing Lys Wing Glu Met Asp Glu He He Wing 100 105 110 Val His Ser Glu Asn Asn Ala Wing Leu Pro Gly Val Lys Gln Ser Ser 115 120 125 Gly Gln Wing Ser Gly Gln Val Ser Ser Lys His Thr His Met Ser He 130 135 140 Gly Glu Val Leu Ser Asn Lys Trp Leu Val Arg Leu Leu He Wing Gly 145 150 155 160 He Gly Val Ala Val Ala Gln Gln Leu Thr Gly He Asn Wing He Met 165 170 175 Tyr Tyr Gly Thr Arg Val Leu Glu Glu Ser Gly Met Ser Ala Glu Met 25 180 185 190 iaás t fcj. ... .. ~ i Al .i Wing Val Val Wing Asn He Wing Phe Gly Wing Val Wing Val He Gly Gly 195 200 205 Leu He Wing Leu Arg Asn Met Asp Arg Leu Asp Arg Arg Thr Thr Phe 210 215 220 He He Gly Leu Ser Leu Thr Thr Thr Phe His Leu Leu He Ala Wing 225 230 235 240 Wing Gly Thr Leu Leu Pro Glu Gly Asn Ser He Arg Pro Phe Wing He 245 250 255 Met He Leu Val Val Gly Phe Val Leu Ser Met Gln Thr Phe Leu Asn • 260 265 270 Val Ala Val Trp Val Trp Leu Ala Glu He Phe Pro Val Arg Met Lys 275 280 285 Gly He Gly Thr Gly He Ser Val Phe Cys Gly Trp Gly He Asn Gly 290 295 300 Val Leu Ala Leu Phe Phe Pro Ala Leu Val Ser Gly Val Gly He Thr 305 310 315 320 Phe Ser Phe Leu He Phe Wing Val Val Gly Val He Wing Leu Wing Phe 325 330 335 Val Thr Lys Phe Val Pro Glu Thr Arg Gly Arg Ser Leu Glu Glu Leu 340 345 350 10 Asp His Ala Ala Phe Thr Gly Gln He Phe Lys Lys Ala 355 360 365 < 210 > 547 < 211 > 2013 < 212 > DNA < 213 > Corynebact: erium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1990) < 223 > RXN02395 15 < 400 > 547 aaacagg; aat; attt; aactt: g acttcttaaa aaagctctat acgtaaatat <; ? ttgcccatc 60 cagcaccacc itcattgtggt g < agagcacac atg tcc acc aac tet 115 Met Ser Thr Asn Ser 1 5 ggc aat aac ttg ect gaa tc cca gag tca ccc gag gaa ect cat tat 163 Gly Asn Asn Leu Pro Glu Ser Gln Glu Ser Pro Glu Glu Pro His Tyr 10 15 20 • ect falls gac acc falls cca ggc cta gtt ect ggc att tcg gtc gat gct 211 Pro His Asp Thr His Pro Gly Leu Val Pro Gly He Ser Val Asp Ala 25 30 35 20 caa cgc aac aag ttc gga etc gac aaa acc gtt ttc ggc gtc acc gca 259 Gln Arg Asn Lys Phe Gly Leu Asp Lys Thr Val Phe Gly Val Thr Wing 40 45 50 gca tta att ctg gcg ttc ate gcc tgg ggc att tcc age ect gat tcg 307 Ala Leu He Leu Ala Phe He Wing Trp Gly He Ser Ser Pro Asp Ser 55 60 65 gtt tet tca gta tcg tcc acg atg ttc agt tgg gct atg acg aat act 355 Val Ser Ser Val Ser Ser Thr Met Phe Ser Trp Wing Met Thr Asn Thr 70 75 80 85 ggt tgg etc etc aac ttt gtc atg ctg ate ggc att ggc acc atg etc. 403 Gly Trp Leu Leu Asn Phe Val Met Leu He Gly He Gly Thr Met Leu 90 95 100 25 tac ate gct ttt tcg cgc tac ggc cgc ate aag ctg ggc acg gac gaa 451 Íá ^^ t¿ ^ 4fe¡ ^^ b¿ * «? ^^? ¿^ Fc * ^^^ k iA? A. A.

Tyr He Wing Phe Ser Arg Tyr Gly Arg He Lys Leu Gly Thr Asp Glu 105 110 115 gac gaa cca gaa ttc tet cgc ttt tcc tgg att gcg atg tgc gtc 99 Asp Glu Pro Glu Phe Ser Arg Phe Ser Trp He Wing Met Met Met Phe Gly 120 125 130 gcc ggc ate ggt gtc ggt ate ttc ttc ttc ggt ect tcc gaa ccg ctg 547 Wing Gly He Gly Val Gly He Phe Phe Phe Gly Pro Ser Glu Pro Leu 135 140 145 tgg cat tat etc agt ccc cca ect falls acc gtg gaa gga tet here ect 595 • Trp His Tyr Leu Ser Pro Pro Pro His Thr Val Glu Gly Ser Thr Pro 150 155 160 165 gag tcc ttg falls ca gca ctt gcg cag tcc falls ttc falls tgg ggc tta 643 Glu Ser Leu His Gln Ala Leu Ala Gln Ser His Phe His Trp Gly Leu 170 175 180 tcc gcc tgg ggg ctg tat gcc ttg gtc ggc ggc gcg ttg gcg tac tcc 691 Be Ala Trp Gly Leu Tyr Ala Leu Val Gly Gly Ala Leu Ala Tyr Ser 185 190 195 agt tac cgc ggc cgc gta acc ttg ate age tcc acc ttc cgg tca 739 Be Tyr Arg Arg Gly Arg Val Thr Leu Be Ser Thr Phe Arg Ser 200 205 210 ttc ggt gag aaa acc gaa gt ate gcg ggt cgc etc ate gac atg 787 10 ctt g Leu Phe Gly Glu Lys Thr Glu Gly He Wing Gly Arg Leu He Asp Met 215 220 225 atg gcg ate ate gcc acg ctg ttt gga acg gct gca acc ttg ggc ctt 835 • Met Wing He Wing Thr Leu Phe Gly Thr Wing Wing Thr Leu Gly Leu 230 235 240 245 tca gca att cag gtt ggt cag ggc gtg cag att att tet ggc gct tcg Ser Ala He Gln Val Gly Gln Gly Val Gln He He Ser Gly Ala Ser 250 255 260 gaa ate acc aac aac ate ttg ate gcc ate ate gcg ate ttg acc att 931 Glu He Thr Asn Asn He Leu He Wing He He Wing He Leu Thr He 265 270 275 15 ggc ttc ate ate tcc tca gta tet ggc gtg tcc aag ggc att cgt tat 979 Gly Phe He He Ser Ser Val Ser Gly Val Ser Lys Gly He Arg Tyr 280 285 290 ctt tcc aac etc aat tcc ttg acg ctt gga ttg gtc ctg ttt gtg 1027 Leu Ser Asn Leu Asn He Be Leu Thr Leu Gly Leu Val Leu Phe Val 295 300 305 ttc ate acc ggc ccc acc ttg ttc ctg etc aac ttg ate cca tcg agt 1075 Phe He Thr Gly Pro Thr Leu Phe Leu Leu Asn Leu He Pro Ser Ser 310 315 320 325 • gtg ttg gaa tat ggc agt gag ttc ttg tca atg gct ggc aag tet ttg 1123 Val Leu Glu Tyr Gly Ser Glu Phe Leu Ser Met Wing Gly Lys Ser Leu 330 335 340 20 tcg tgg ggt gag gaa acc att gaa ttc caa gct ggg tgg acg gcg ttc 1171 Be Trp Gly Glu Glu Thr He Glu Phe Gln Wing Gly Trp Thr Wing Phe 345 350 355 tac tgg gca tgg tgg tgg tgg ate gca tgg act cca ttc ggt atg ttc ate 1219 Tyr Trp Wing Trp Trp He Wing Trp Thr Pro Phe Val Gly Met Phe He 360 360 370 gcg cgt att tet cgc ggc cgc acc ttg cgt gaa ttc gcg etc ate acc 1267 Wing Arg He Ser Arg Gly Arg Thr Leu Arg Glu Phe Wing Leu He Thr 375 380 385 atg gct ate ccc tcc ttc att ttg ate ctg gcg ttc acc att ttc ggt 1315 Met Ala He Pro Ser Phe He Leu He Leu Ala Phe Thr He Phe Gly 390 395 400 405 25 gga act gcc ate acg atg aac cgc gag aac gta gat ggt ttt gac ggc 1363 '.ial.fcii-iAü Gly Thr Ala He Thr Met Asn Arg Glu Asn Val Asp Gly Phe Asp Gly 410 415 420 agt tca tag aag gaa cag gtg ctg ttt gat atg ttc age aac ctt ccg 1411 Being Being Lys Glu Gln Val Leu Phe Asp Met Phe Being Asn Leu Pro 425 430 435 ctg tac tcg ate here ccg ttc att ttg ate ttt gtg ctg gca gta ttc 1459 Leu Tyr Ser He Thr Pro Phe He Leu He Phe Val Leu Wing Val Phe 440 445 450 ttt gtt acc tet gcc gat tcc gcc tcc gtg gtg atg gga acg atg age 1507 Phe Val Thr Ser Wing Asp Ser Wing Val Val Met Met Gly Thr Met Ser 455 460 465 tcc caa ggt aac ect gca cca aac aaa tta ate gtg gtg ttc tgg gga 1555 Ser Gln Gly Asn Pro Wing Pro Asn Lys Leu He Val Val Phe Trp Gly 470 475 480 485 ctg tgc atg atg ggc ate gcg gtg gtc atg ctg ctt act ggt ggc gaa 1603 Leu Cys Met Met Gly He Wing Val Val Met Leu Leu Thr Gly Gly Glu 490 495 500 tcc gcg ctg act ggt ctg cag aac etc acc att ttg ate gcc att ccg 1651 Be Ala Leu Thr Gly Leu Gln Asn Leu Thr He Leu He Wing Pro 505 510 515 ttt gcg ctg gtg ttg ate gtg atg gct att gcc ttt att aag gac tta 1699 Phe Ala Leu Val Leu He Val Met Ala He Ala Phe He Lys Asp Leu 520 525 530 tcc here gac cca gcc gct att cga caa cgc tat gca aag gca gcc ate 1747 Be Thr Asp Pro Wing Wing He Arg Gln Arg Tyr Wing Lys Wing Wing He 535 540 545 tet aac gcg gtg gtt cgt ggc ttg gaa gaa falls ggc gac gac ttc gag 1795 Ser Asn Ala Val Val Arg Gly Leu Glu Glu His Gly Asp Asp Phe Glu 550 555 560 565 etc tcc ate gaa ect gca gag ggt ggt gg ggt ggt gct gct gtc acc ttc 1843 Leu Ser He Glu Pro Wing Glu Glu Gly Gly Arg Gly Wing Gly Wing Thr Phe 570 575 580 gat tcc acc gct gat cae ate acc gac tgg tat cag cgc acc gac gaa 1891 Asp Ser Thr Wing Asp His He Thr Asp Trp Tyr Gln Arg Thr Asp Glu 585 590 595 gaa ggc aat gat gtt gat tat gac ttc acc acc ggc aaa tgg gcc gat 1939 Glu Gly Asn. Asp Val Asp Tyr Asp Phe Thr Thr Gly Lys Trp Wing Asp 600 605 610 ggt tgg here ccg gaa tcg acc gaa ggc gaa gtg gac gcg aaa aag 1987 Gly Trp Thr Pro Glu Ser Thr Glu Glu Glu Glu Val Asp Ala Lys Lys 615 620 625 gat taaaaaataa cgactggctg gga 2013 Asp 630 < 210 > 548 < 211 > 630 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 548 Met Ser Thr Asn Ser Gly Asn Asn Leu Pro Glu Ser Gln Glu Ser Pro 1 5 10 15 Glu Glu Pro His Tyr Pro His Asp Thr His Pro Gly Leu Val Pro Gly 20 25 30 He Ser Val Asp Ala Gln Arg Asn Lys Phe Gly Leu Asp Lys Thr Val 35 40 45 Phe Gly Val Thr Wing Wing Leu He Leu Wing Phe He Wing Trp Gly He 50 55 60 Ser Ser Pro Asp Ser Val Ser Val Val Ser Ser Thr Met Phe Ser Trp 65 70 75 80 Wing Met Thr Asn Thr Gly Trp Leu Leu Asn Phe Val Met Leu He Gly 85 90 95 He Gly Thr Met Leu Tyr He Wing Phe Ser Arg Tyr Gly Arg He Lys 100 105 110 Leu Gly Thr Asp Glu Asp Glu Pro Glu Phe Ser Arg Phe Ser Trp He • 115 120 125 Wing Met Met Phe Gly Wing Gly He Gly Val Gly He Phe Phe Phe Gly 130 135 140 Pro Ser Glu Pro Leu Trp His Tyr Leu Ser Pro Pro Pro His Thr Val 145 150 155 160 Glu Gly Ser Thr Pro Glu Ser Leu His Gln Ala Leu Ala Gln Ser His 165 170 175 Phe His Trp Gly Leu Ser Wing Trp Gly Leu Tyr Wing Leu Val Gly Gly 180 185 190 Wing Leu Wing Tyr Being Ser Tyr Arg Arg Gly Arg Val Thr Leu He Ser 195 200 205 10 Being Thr Phe Arg Being Leu Phe Gly Glu Lys Thr Glu Gly He Wing Gly 210 215 220 Arg Leu He Asp Met Met Wing He He Wing Thr Leu Phe Gly Thr Wing 225 230 235 240 • Wing Thr Leu Gly Leu Being Wing He Gln Val Gly Gln Gly Val Gln He 245 250 255 He Ser Gly Wing Being Glu He Thr Asn Asn He Leu He Wing He He 260 265 270 Wing He Leu Thr He Gly Phe He He Was To Be Val Ser Gly Val Ser 275 280 285 Lys Gly He Arg Tyr Leu Ser Asn Leu Asn He Ser Leu Thr Leu Gly 290 295 300 15 Leu Val Leu Phe Val Phe He Thr Gly Pro Thr Leu Phe Leu Leu Asn 305 310 315 320 Leu He Pro Ser Ser Val Leu Glu Tyr Gly Ser Glu Phe Leu Ser Met 325 330 335 Wing Gly Lys Ser Leu Ser Trp Gly Glu Glu Thr He Glu Phe Gln Wing 340 345 350 Gly Trp Thr Wing Phe Tyr Trp Wing Trp Trp He Wing Trp Thr Pro Phe 355 360 365 Val Gly Met Phe He Wing Arg He Ser Arg Gly Arg Thr Leu Arg Glu 370 375 380 Phe Wing Leu He Thr Met Wing He Pro Being Phe He Leu He Leu Wing 385 390 395 400 20 Phe Thr He Phe Gly Gly Thr Wing He Thr Met Asn Arg Glu Asn Val 405 410 415 Asp Gly Phe Asp Gly Ser Ser Lys Glu Gln Val Leu Phe Asp Met 420 425 430 Phe Ser Asn Leu Pro Leu Tyr Ser He Thr Pro Phe He Leu He Phe 435 440 445 Val Leu Ala Val Phe Phe Val Thr Ser Ala Asp Ser Ala Ser Val Val 450 455 460 Met Gly Thr Met Ser Ser Gln Gly Asn Pro Ala Pro Asn Lys Leu He 465 470 475 480 Val Val Phe Trp Gly Leu Cys Met Met Gly He Wing Val Val Met Leu 485 490 495 25 Leu Thr Gly Gly Glu Be Ala Leu Thr Gly Leu Gln Asn Leu Thr He 500 505 510 Leu He Ala He Pro Phe Ala Leu Val Leu He Val Met Wing Wing 515 520 525 Phe He Lys Asp Leu Ser Thr Asp Pro Wing Wing Arg Gln Arg Tyr 530 535 540 Wing Lys Wing Wing He As Asn Wing Val Valg Arg Gly Leu Glu Glu His 545 550 555 560 Gly Asp Asp Phe Glu Leu Ser He Glu Pro Wing Glu Glu Gly Arg Gly 565 570 575 Wing Gly Wing Thr Phe Asp Ser Thr Wing Asp His He Thr Asp Trp Tyr 580 585 590 Gln Arg Thr Asp Glu Glu Gly Asn Asp Val Asp Tyr Asp Phe Thr Thr 595 600 605 Gly Lys Trp Wing Asp Gly Trp Thr Pro Glu Ser Thr Glu Glu Glu 610 615 620 Val Asp Wing Lys Lys Asp 625 630 < 210 > 549 < 211 > 2007 10 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > • < 221 > CDS < 222 > (101) .. (1984) < 223 > RXN02348 < 400 > 549 aaaigaccega igccgaagccc tggcctgcgt 2 at; acttcctt gtcaacgctc < gctgggatta 60 ggt < ettttct < gagegetatge aitttcltecae tcaaaggagc atg ctt aac cgc atg 115 Met Leu Asn Arg Met 15 1 5 aaa agt gcg cgg cca aaa tca gtc gct cca aaa tcc gga caa gct tta 163 Lys Ser Wing Arg Pro Lys Ser Val Wing Pro Lys Ser Gly Gln Wing Leu 10 15 20 etc etc act ggt gcc gta gtt gtt gtg gtc gtc gac ate ggc acc age 211 Leu Thr Leu Gly Ala Leu Gly Val Val Phe Gly Asp He Gly Thr Ser 25 30 ccc ctg tac tca ctt falls act gca ttc age atg cag cae aac aaa gtc 259 Pro Leu Tyr Ser Leu His Thr Wing Phe Ser Met Gln His Asn Lys Val • 40 45 50 gaa gtc act cag gaa aat gtg tac ggc ate ate tcc atg gtg ttg tgg 307 Glu Val Thr Gln Glu Asn Val Tyr Gly He He Ser Met Val Leu Trp 20 55 60 65 acc ate act ttg ate gtc acc gtc aaa tac gtc atg ctg gtc acc ac 355 Thr He Thr Leu He Val Thr Val Lys Tyr Val Met Leu Val Thr Arg 70 75 80 85 gct gac aac caa gga caa ggt ggc ate ctg gcg etc gtt gct ttg ctg 403 Wing Asp Asn Gln Gly Gln Gly Gly He Leu Wing Leu Val Wing Leu Leu 90 95 100 aaa aac cgt ggg falls tgg gga aaa ttc gtg gca gta gcc ggc atg ttg 451 Lys Asn Arg Gly His Trp Gly Lys Phe Val Wing Val Wing Gly Met Leu 105 110 115 ggc gcc gt gt ttt tat ggc gat gtg gtg ate acc ccg gcg ate tet 499 Gly Ala Ala Leu Phe Tyr Gly Asp Val Val He Thr Pro Ala He Ser 25 120 125 130 LY r ?? r.4Í.? M ^ > t. gtt etc age gca here gaa ggc ttg acg gtt ate tcc cca age ttt gag 547 Val Leu Ser Ala Thr Glu Gly Leu Thr Val He Ser Pro Ser Phe Glu 135 140 145 cgc ttc att ctg ccc gta tet etc gca gtt ctg ate gct att ttt gca 595 Arg Phe He Leu Pro Val Ser Leu Ala Val Leu He Ala He Phe Wing 150 155 160 165 ate caa ccg etc ggt here gaa aaa gtc ggc aaa gcc ttc ggc ccc ate 643 He Gln PPrroo LLeeuu GGllyy TThhrr Glu Lys Val Gly Lys Wing Phe Gly Pro He 170 175 180 • atg ttg ctg tgg ttt gtc acc ctt gca gga ttg gga att ccg caa ate 691 Met Leu Leu Trp Phe Val Thr Leu Wing Gly Leu Gly He Pro Gln He 185 190 195 ate ggg falls cca gaa ate ttg cag age ttg tet cca cat tgg gcc ctg 739 He Gly His Pro Glu He Leu Gln Ser Leu Ser Pro His Trp Wing Leu 200 205 210 cgc ttg att gtg gct gct gag ect ttc caa gca ttt gtg ctg ctt ggt gcc 787 Arg Leu He Val Ala Glu Pro Phe Gln Ala Phe Val Leu Leu Gly Ala 215 220 225 gtt gtc ctg here gta acg ggt gcg gaa gcg etc tac gct gat atg ggc 835 Val Val Leu Thr Val Thr Gly Ala Glu A the Leu Tyr Wing Asp Met Gly 10 230 235 240 245 cat ttt ggg gcg agg cca gga aga gtg ggg ggg tgg tgc gtc gtc gtc atg 883 His Phe Gly Ala Arg Pro He Arg Val Wing Trp Phe Cys Val Val Met 250 255 260 ect gct tta ate ttg acg tat ttg ggg cag ggc gcc ttg gtg ate aac 931 • Pro Ala Leu He Leu Thr Tyr Leu Gly Gln Gly Ala Leu Val He Asn 265 270 275 cag ect gaa gcg gtg cgc aac ccc att ttt tat etc gcg ccg gaa ggt 979 Gln Pro Glu Ala Val Arg Asn Pro Met Phe Tyr Leu Ala Pro Glu Gly 280 285 290 ctg cgg att ccg ttg gtt att ttg gcg acc ate gct acg gtg ate gca 1027 Leu Arg He Pro Leu Val He Leu Wing Thr He Wing Thr Val He Wing 15 295 300 305 tcg cag gcc gtg att tet ggt gcg tat tca ttg acc aag cag gcc gtg 1075 Ser Gln Wing Val He Ser Gly Wing Tyr Ser Leu Thr Lys Gln Wing Val 310 315 320 325 aat ttg aaa ctg ctg cca cgc atg gtg ate cgg cat acc tcc cgc aaa 1123 Asn Leu Lys Leu Leu Pro Arg Met Val He Arg His Thr Ser Arg Lys 330 335 340 gag gag ggc cag ate tat atg cca ctg gtt aat gga ttg ctg ttt gta 1171 Glu Glu Gly Gln He Tyr Met Pro Leu Val Asn Gly Leu Leu Phe Val 345 350 355 • tcc gtg atg gtt gtg gtg ctg gta ttc cga tcc tet gaa age etc gcc 1219 Ser Val Met Val Val Val Leu Val Phe Arg Ser Ser Glu Ser Leu Ala 20 360 365 370 age gcg tac gga ctt gca g tg acc gga acc ttg gtg ctg gtc age gtc 1267 Be Wing Tyr Gly Leu Wing Val Thr Gly Thr Leu Val Leu Val Ser Val 375 380 385 ctg tat ctg tat tat gtt drops acc tà tgg tgg aaa here gcg ctg ttc 1315 Leu Tyr Leu He Tyr Val His Thr Thr Trp Trp Lys Thr Ala Leu Phe 390 395 400 405 Att gtg att ggt att cca gaa gta cctttt ccttaa ttttcc ggcccc ttccgg aaaacc aacccc 1363 He Val Leu He Gly He Pro Glu Val Leu Leu Phe Wing Being Asn Thr 410 415 420 acg aaa att falls gac ggt ggc tgg ctt ccccaa ccttaa cctttt aatttt ggccgg ggcccc ggttgg 1411 Thr Lys He His Asp Gly Gly Trp Leu Pro Leu Leu He Ala Wing Val 25 425 430 435 etc ate gtg gtg atg cgg acc tgg gag tgg gga agt gac cgc gtc aat 1459 Leu He Val Val Met Arg Thr Trp Glu Trp Gly Ser Asp Arg Val Asn 440 445 450 cag gaa cgc gca gag ctg gaa ctt ccc atg gat aag ttc ttg gag aaa 1507 Gln Glu Arg Ala Glu Leu Glu Leu Pro Met Asp Lys Phe Leu Glu Lys 455 460 465 etc. gat cag cca falls aat att ggt ctg cgt aaa gtt gcc gaa gtg gca 1555 Leu Asp Gln Pro His Asn He Gly Leu Arg Lys Val Wing Glu Val Wing 470 475 480 485 • gta ttt cca cat ggc acc age gat act gtc ccg ttg tca ttg gtt cgc 1603 Val Phe Pro His Gly Thr Ser Asp Thr Val Pro Leu Ser Leu Val Arg 490 495 500 tgc gtg aaa gac etc aag ctt tta tac cga gag ate gtg ate gtt cga 1651 Cys Val Lys Asp Leu Lys Leu Leu Tyr Arg Glu He Val He Val Arg 505 510 515 ate gtc caa gaa falls gtt ccg falls gtg cca cca gag gaa cgc gcg gaa 1699 He Val Gln Glu His Val Pro His Val Pro Pro Glu Glu Arg Ala Glu 520 525 530 atg gaa gtg etc cat drops gcc ccg ate aga gtc gtg cga gtt gat ctg 1747 Met Glu Val Leu His His Wing Pro He Arg Val Val Arg Val Asp Leu 535 540 545 10 falls ctt ggt tat ttt gat gag cag aac ctg ect gag cat etc cat gcc 1795 His Leu Gly Tyr Phe Asp Glu Gln Asn Leu Pro Glu His Leu His Ala 550 555 560 565 • att gac cca here tgg gat aac gcc acc tac ttc ctg tet gcc ctg act 1843. He Asp Pro Thr Trp Asp Asn Ala Thr Tyr Phe Leu Ser Ala Leu Thr 570 575 580 ctt CGG age agg ttg ect GGA AAG att GCT GGC TGG CGT gat cgt ttg 1891 Leu Arg Be Arg Leu Pro Gly Lys He Wing Gly Trp Arg Asp Arg Leu 585 590 595 tat ctt tcg atg gaa cgt aat cag gca tet cga act gag tet ttc aaa 1939 Tyr Leu Ser Met Glu Arg Asn Gln Wing Ser Arg Thr Glu Ser Phe Lys 600 605 610 15 ttg caa cca age aaa acc ate acg gtt gga here gag ctg falls ctt 1984 Leu Gln Pro Ser Lys Thr He Thr Val Gly Thr Glu Leu His Leu 615 620 625 taatcaggca gttgctggcc aac 2007 < 210 > 550 < 211 > 628 < 212 > PRT • < 213 > Corynebacterium glutamicum < 400 > 550 Met Leu Asn Arg Met Lys Ser Wing Arg Pro Lys Ser Val Wing Pro Lys 20 1 5 10 15 Ser Gly Gln Wing Leu Leu Thr Leu Gly Wing Leu Gly Val Val Phe Gly 20 25 30 Asp He Gly Thr Ser Pro Leu Tyr Ser Leu His Thr Wing Phe Ser Met 35 40 45 Gln His Asn Lys Val Glu Val Thr Gln Glu Asn Val Tyr Gly He He 50 55 60 Ser Met Val Leu Trp Thr He Thr Leu He Val Thr Val Lys Tyr Val 65 70 75 80 Met Leu Val Thr Arg Wing Asp Asn Gln Gly Gln Gly Gly He Leu Wing 85 90 95 25 Leu Val Wing Leu Leu Lys Asn Arg Gly His Trp Gly Lys Phe Val Wing | g ^ i | ií ^ 6¿ £ ^^^ ii? i __ ^ ifflJ »100 105 110 Val Ala Gly Met Leu Gly Ala Ala Leu Phe Tyr Gly Asp Val Val He 115 120 125 Thr Pro Ala He Ser Val Leu Ser Wing Thr Glu Gly Leu Thr Val He 130 135 140 Ser Pro Be Phe Glu Arg Phe He Leu Pro Val Ser Leu Wing Val Leu 145 150 155 160 He Wing He Phe Wing He Gln Pro Leu Gly Thr Glu Lys Val Gly Lys 165 170 175 • Wing Phe Gly Pro He Met Leu Leu Trp Phe Val Thr Leu Wing Gly Leu 180 185 190 Gly He Pro Gln He He Gly His Pro Glu He Leu Gln Ser Leu Ser 195 200 205 Pro His Trp Ala Leu Arg Leu He Val Ala Glu Pro Phe Gln Wing Phe 210 215 220 Val Leu Leu Gly Wing Val Val Leu Thr Val Thr Gly Ala Glu Ala Leu 225 230 235 240 Tyr Wing Asp Met Gly His Phe Gly Wing Arg Pro He Arg Val Wing Trp 245 250 255 Phe Cys Val Val Met Pro Ala Leu He Leu Thr Tyr Leu Gly Gln Gly 10 260 265 270 Ala Leu Val He Asn Gln Pro Glu Ala Val Arg Asn Pro Met Phe Tyr 275 280 285 Leu Ala Pro Glu Gly Leu Arg He Pro Leu Val He Leu Ala Thr He • 290 295 300 Wing Thr Val He A the Ser Gln Wing Val He Ser Gly Wing Tyr Ser Leu 305 310 315 320 Thr Lys Gln Wing Val Asn Leu Lys Leu Pro Arg Met Val He Arg 325 330 335 His Thr Ser Arg Lys Glu Glu Gly Gln He Tyr Met Pro Leu Val Asn 340 345 350 Gly Leu Leu Phe Val Ser Val Val Val Leu Val Phe Arg Ser 15 355 360 365 Ser Glu Ser Leu Ala Ser Wing Tyr Gly Leu Wing Val Thr Gly Thr Leu 370 375 380 Val Leu Val Ser Val Leu Tyr Leu He Tyr Val His Thr Thr Trp Trp 385 390 395 400 Lys Thr Wing Leu Phe He Val Leu He Gly He Pro Glu Val Leu Leu 405 410 415 Phe Wing Ser Asn Thr Thr Lys He His Asp Gly Gly Trp Leu Pro Leu 420 425 430 • Leu He Ala Ala Val Leu He Val Val Met Arg Thr Trp Glu Trp Gly 435 440 445 Ser Asp Arg Val Asn Gln Glu Arg Ala Glu Leu Glu Leu Pro Met Asp 20 450 455 460 Lys Phe Leu Glu Lys Leu Asp Gln Pro His Asn He Gly Leu Arg Lys 465 470 475 480 Val Wing Glu Val Wing Val Phe Pro His Gly Thr Ser Asp Thr Val Pro 485 490 495 Leu Ser Leu Val Arg Cys Val Lys Asp Leu Lys Leu Leu Tyr Arg Glu 500 5 05 510 He Val He Val Arg He Val Gln Glu His Val Pro His Val Pro Pro 515 520 525 Glu Glu Arg Ala Glu Met Glu Val Leu His His Ala Pro He Arg Val 530 535 540 Val Arg Val Asp Leu His Leu Gly Tyr Phe Asp Glu Gln Asn Leu Pro 25 545 550 555 560 ÍA ±? A ** l «A *. * ^^ r ^ r r. "4 ^ 4.» «, __» »AA, Glu His Leu His Wing He Asp Pro Thr Trp Asp Asn Wing Thr Tyr Phe 565 570 575 Leu Ser Wing Leu Thr Leu Arg Ser Arg Leu Pro Gly Lys He Wing Gly 580 585 590 Trp Arg Asp Arg Leu Tyr Leu Ser Met Glu Arg Asn Gln Wing Ser Arg 595 600 605 Thr Glu Ser Phe Lys Leu Gln Pro Ser Lys Thr He Thr Val Gly Thr 610 615 620 Glu Leu His Leu 625 < 210 > 551 < 211 > 1035 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1012) < 223 > RXN00297 0 < 400 > 551 aacaaggcac < cgga; aaacaa gcaactgeace ttcgcagaggt ggtcttaagc; atettggage 60 aaaacaacat < ggcacaat; aa ctgatcatgc; a acaggtgctc atg ggt ttc acg gtg 115 Met Gly Phe Thr Val 1 5 gtg ttc ate gtc ate gga ata ggt tgg att etc ggt aga aga gac acc 163 Val Phe He Val He Gly He Gly Trp He Leu Gly Arg Arg Asp Thr 10 15 20 ttg ggc here cat gcc cag aaa ect ttg age ctg ttt gtc tat tac gtg 211 Leu Gly Thr His Wing Gln Lys Pro Leu Ser Leu Phe Val Tyr Tyr Val 25 30 35 5 cc acc cca gcg ttg ttg ttt gat cgg gtc acc aag tca gat acc tcg 259 Wing Thr Pro Ala Leu Leu Phe Asp Arg Val Thr Lys Be Asp Thr Ser 40 45 50 acg att ttc tet ctg aac ttc gtg gtc att gca etc tet gcg ttg ate 307 Thr He Phe Ser Leu Asn Phe Val Val He Ala Leu Ser Ala Leu He 55 60 65 gta ggt ttc ctg ttt ttc cta etc atg cgg ttc gtg ate aaa aga act 355 Val Gly Phe Leu Phe Phe Leu Leu Met Arg Phe Val He Lys Arg Thr 70 75 80 85 gcc gca gta tcg gtg ate ggc atg cta gct gcg tcc tac gcc aac gcc 403 Ala Ala Val Ser Val He Gly Met Leu Ala Ala Ser Tyr Ala Asn Ala 90 95 100 0 ggt aac ctg ggt ate ect ttg gca gcc tat att ttg gat gat ttc acc 451 Gly Asn Leu Gly He Pro Leu Ala Ala Tyr He Leu Asp Asp Phe Thr 105 110 115 gtg gtg att ccc gtg att ttg ttc cag gtg gcg ttc tac gc ccg ate 499 Val Val He Pro Val He Leu Phe Gln Val Wing Phe Tyr Ala Pro He 120 125 130 acc atg acc ate atg gag atg ctg acc aac aag aaa tcc acc aac ttg 547 Thr Met Thr Met Met Glu Met Leu Thr Asn Lys Lys Ser Thr Asn Leu 135 140 145 gtg cgc aac etc ctg gtc acg cca cta acc aac acc atg gtg etc gca 595 Val Arg Asn Leu Leu Val Thr Pro Leu Thr Asn Thr Met Val Leu Wing 150 155 160 165 -. gcg att gcc ggt att gct gtg tet ttg act tcg atg age gtg ccc gtg 643 Wing Wing Wing Gly Wing Wing Val Ser Leu Thr Ser Wing Val Val Valve 175 175 180 gtg att gct cag cca gtg gaa atg ttg gcg aat gct tca gtg cca ctg 691 Val He Wing Gln Pro Val Glu Met Leu Wing Asn Wing Val Pro Leu 185 190 195 gct ttg gtg gtg ttc gga ctg tcc ttg tcc aag age aag ate ctg gaa 739 Ala Leu Val Val Phe Gly Leu Ser Leu Ser Lys Ser Lys He Leu Glu 200 205 210 aag ggg cag gta tcc agg cgc gat gtg ttt acg gcg gca ctg ttc aag 787 Lys Gly Gln Val Ser Arg Arg Asp Val Phe Thr Ala Ala Leu Phe Lys 215 220 225 aat gtt ctg falls cca att gtt gcg gga ctt tta gcc tta gcc ttt ggt 835 Asn Val Leu His Pro He Val Ala Gly Leu Leu Ala Leu Ala Phe Gly 230 235 240 245 atg gaa ggt act gcc ttg ttg tcg gcg gtg att etc ggt gca ctg cca 883 Met Glu Gly Thr Ala Leu Leu Ser Wing Val He Leu Gly Ala Leu Pro 250 255 260 here gcg cag aat gtc tac acc tac gcg ttg cga ttt aga here gct gaa 931 Thr Ala Gln Asn Val Tyr Thr Tyr Ala Leu Arg Phe Arg Thr Ala Glu 265 270 275 tcg atg gcg aga gac here ggg gtg gtc acc here etc tcc tc ccc 979 Ser Met Ala Arg Asp Thr Gly Val Val Thr Thu Leu He Ser Phe Pro 280 285 290 gta ttg gtg gcg gtc tcc att ate ttt gga tet tagggttagc attagtggtc 1032 Val Leu Val Ala Val Ser He He Phe Gly Ser 295 300 atg 1035 < 210 > 552 < 211 > 304 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 552 Met Gly Phe Thr Val Val Phe He Val He Gly He Gly Trp He Leu 1 5 10 15 Gly Arg Arg Asp Thr Leu Gly Thr His Wing Gln Lys Pro Leu Ser Leu 20 25 30 Phe Val Tyr Tyr Val Ala Thr Pro Ala Leu Leu Phe Asp Arg Val Thr 35 40 45 Lys Ser Asp Thr Ser Thr He Phe Ser Leu Asn Phe Val Val He Wing 50 55 60 Leu Ser Wing Leu He Val Gly Phe Leu Phe Phe Leu Leu Met Arg Phe 65 70 75 80 Val He Lys Arg Thr Ala Ala Val Ser Val He Gly Met Leu Ala Ala 85 90 95 Ser Tyr Ala Asn Ala Gly Asn Leu Gly He Pro Leu Ala Ala Tyr He 100 105 110 Leu Asp Asp Phe Thr Val Val He Pro Val He Leu Phe Gln Val Ala 115 120 125 Phe Tyr Ala Pro He Thr Met Thr Met Met Glu Met Leu Thr Asn Lys 130 135 140 Lys Ser Thr Asn Leu Val Arg Asn Leu Leu Val Thr Pro Leu Thr Asn 145 150 155 160 Thr Met Val Leu Ala Ala He Wing Gly He Wing Val Ser Leu Thr Ser 165 170 175 Met Ser Val Pro Val Val He Wing Gln Pro Val Glu Met Leu Ala Asn 180 185 190 Ala Ser Val Pro Leu Ala Leu Val Val Phe Gly Leu Ser Leu Ser Lys 195 200 205 Ser Lys He Leu Glu Lys Gly Gln Val Ser Arg Arg Asp Val Phe Thr 210 215 220 Ala Ala Leu Phe Lys Asn Val Leu His Pro He Val Ala Ala Gly Leu Leu 225 230 235 240 Ala Leu Ala Phe Gly Met Glu Gly Thr Ala Leu Leu Ser Ala Ala He 245 250 255 Leu Gly Ala Leu Pro Thr Ala Gln Asn Val Tyr Thr Tyr Ala Leu Arg 260 265 270 Phe Arg Thr Ala Glu Ser Met Ala Arg Asp Thr Gly Val Val Thr Thr 275 280 285 Leu He Ser Phe Pro Val Leu Val Ala Val Ser He He Phe Gly Ser 290 295 300 < 210 > 553 < 211 > 353 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (343) < 223 > RXN03103 < 400 > 553 atcttcagag teaettettt cagtgtcatt tttctcggcc ctaatccccc gctggagttc 60 aatcagcgat 1tgcaaccttt tagatatata aggagacaac atg tet gca aag cgt 115 Met Ser Ala Lys Arg 1 5 act ttt acc cgt ate ggt gcg att ctt gga gca act gca ctt gcc gga 163 Thr Phe Thr Arg He Gly Wing He Leu Gly Wing Thr Wing Leu Wing Gly 10 15 20 gtt acc etc acc gcc tgt ggt gat tca age ggt ggc gac gga ttc etc 211 Val Thr Leu Thr Wing Cys Gly Asp Being Ser Gly Gly Asp Gly Phe Leu 25 30 35 gca gcc att gaa aat ggt tet gtc aat gtc ggc acc aaa tac gat cag 259 Ala Ala He Glu Asn Gly Ser Val Asn Val Gly Thr Lys Tyr Asp Gln 40 45 50 ect ggt ctt ggc etc cgc aac cca gac aac tcc atg age ggt etc gac 307 Pro Gly Leu Gly Leu Arg Asn Pro Asp Asn Ser Met Be Gly Leu Asp 55 60 65 gtg gat gtt gct gaa tac gta att caa etc cat cgc tgatgacaag 353 Val Asp Val Ala Glu Tyr Val He Gln Leu His Arg 70 75 80 < 210 > 554 < 211 > 81 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 554 Met Ser Ala Lys Arg Thr Phe Thr Arg He Gly Ala He Leu Gly Ala 1 5 10 15 Thr Ala Leu Ala Gly Val Thr Leu Thr Ala Cys Gly Asp Ser Ser Gly 20 25 30 Gly Asp Gly Phe Leu Ala Ala He Glu Asn Gly Ser Val Asn Val Gly 35 40 45 Thr Lys Tyr Asp Gln Pro Gly Leu Gly Leu Arg Asn Pro Asp Asn Ser 50 55 60 Met Ser Gly Leu Asp Val Asp Val Wing Glu Tyr Val He Gln Leu His 65 70 75 80 Arg < 210 > 555 < 211 > 695 < 212 > DNA < 213 > C < orynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (672!) < 223 > RXN02993 < 400 > 555 gtt gct gaa tac gta gtc aac tcc ate gct gat gac aag ggc tgg gat 48 10 Val Wing Glu Tyr Val Val Asn Ser Wing Asp Asp Lys Gly Trp Asp 1 5 10 15 falls ccc acc ate gaa tgg cgt gaa tcc ect tet gcg cag cgt gaa acc 96 His Pro Thr He Glu Trp Arg Glu Ser Pro Be Wing Gln Arg Glu Thr • 20 25 30 etc att caa aac ggt gag gta gac atg ate gca gca acc tac tcc ate 144 Leu He Gln Asn Gly Glu Val Asp Met He Ala Wing Thr Tyr Ser He 35 40 45 aac gct ggc cgt tca gag tcc gtc aac ttc ggt ggc cca tac ctg ctt 192 Asn Wing Gly Arg Ser Glu Ser Val Asn Phe Gly Gly Pro Tyr Leu Leu 50 55 60 acc fall cag gct ctg ctt gtt cgc caa gat gac gat cgc att gaa acc 240 15 Thr His Gln Wing Leu Leu Val Arg Gln Asp Asp Asp Arg He Glu Thr 65 70 75 80 etc gag gac ttg gat aac ggt ttg ate ctg tgc tcc gtt tcc gga tcc 288 Leu Glu Asp Leu Asp Asn Gly Leu He Leu Cys Ser Val Ser Gly Ser 85 90 95 act cca gct cag aag gtc aag gat gtc etc cca ggc gtt cag etc caa 336 Thr Pro Wing Gln Lys Val Lys Asp Val Leu Pro Gly Val Gln Leu Gln 100 105 110 gaa tac gac acc tac tet tcc tgt gtt gag gca ctg tcc cag ggc aac 384 • Glu Tyr Asp Thr Tyr Ser Ser Cys Val Glu Ala Leu Ser Gln Gly Asn 115 120 125 gtt gac gcc ctg acc act gac gcc acc ate etc ttc ggc tac tcc cag 432 20 Val Asp Ala Leu Thr Thr Asp Ala Thr He Leu Phe Gly Tyr Ser Gln 130 135 140 cag tac gaa ggc gac ttc cgc gtt gtg gaa atg gaa aag gac ggc gag 480 Gln Tyr Glu Gly Asp Phe Arg Val Val Glu Met Glu Lys Asp Gly Glu 145 150 155 160 cca ttc acc gac gag tac tac ggc att ggc ctg aag aag gat gac cag 528 Pro Phe Thr Asp Glu Tyr Tyr Gly He Gly Leu Lys Lys Asp Asp Gln 165 170 175 gaa ggc acc gac gct ate aac gcc gca ctt gag cgc atg tac gct gac 576 Glu Gly Thr Asp Wing He Asn Wing Wing Leu Glu Arg Met Tyr Wing Asp 180 185 190 ggc acc ttc cag cga ctg etc acc gag aac etc ggt gaa gac tcc gtg 624 25 Gly Thr Phe Gln Arg Leu Leu Thr Glu Asn Leu Gly Glu Asp Ser Val 195 200 205 gtt gtt gaa gaa ggc acc cca ggt gac etc tcc ttc etc gac gca age 672 Val Val Glu Glu Gly Thr Pro Gly Asp Leu Ser Phe Leu Asp Ala Ser 210 215 220 tagtgtgacg gcttttaaaa gcc 695 < 210 > 556 < 211 > 224 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 556 Val Wing Glu Tyr Val Val Asn Ser Wing Asp Asp Lys Gly Trp Asp 1 5 10 15 His Pro Thr He Glu Trp Arg Glu Ser Pro Be Wing Gln Arg Glu Thr 20 25 30 Leu He Gln Asn Gly Glu Val Asp Met He Ala Ala Thr Tyr Ser He 35 40 45 Asn Ala Gly Arg Ser Glu Ser Val Asn Phe Gly Gly Pro Tyr Leu Leu 50 55 60 Thr His Gln Ala Leu Leu Val Arg Gln Asp Asp 10 Asp Arg He Glu Thr 65 70 75 80 Leu Glu Asp Leu Asp Asn Gly Leu He Leu Cys Ser Val Ser Gly Ser 85 90 95 • Thr Pro Wing Gln Lys Val Lys Asp Val Leu Pro Gly Val Gln Leu Gln 100 105 110 Glu Tyr Asp Thr Tyr Ser Ser Cys Val Glu Ala Leu Ser Gln Gly Asn 115 120 125 Val Asp Wing Leu Thr Thr Asp Wing Thr He Leu Phe Gly Tyr Ser Gln 130 135 140 Gln Tyr Glu Gly Asp Phe Arg Val Val Glu Met Glu Lys Asp Gly Glu 145 150 155 160 Pro Phe Thr Asp Glu Tyr Tyr Gly He Gly Leu 15 Lys Lys Asp Asp Gln 165 170 175 Glu Gly Thr Asp Wing He Asn Wing Wing Leu Glu Arg Met Tyr Wing Asp 180 185 190 Gly Thr Phe Gln Arg Leu Leu Thr Glu Asn Leu Gly Glu Asp Ser Val 19 5 200 205 Val Val Glu Glu Gly Thr Pro Gly Asp Leu Ser Phe Leu Asp Wing Ser 210 215 220 • < 210 > 557 < 211 > 1590 < 212 > DNA 20 < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1567) < 223 > RXN00349 < 400 > 557 tgtgtacatc acaatggaat tcggggctag agtatetggt gaaccgtgca taaacgacct 60 gtgattggac tctttttcct tgcaaaatgt tttcagcgg atg ttg agt ttt gcg 115 Met Leu Ser Phe Wing 1 5 25 acc ctt cgt ggc cgc att tca here gtt gac gct gca aaa gcc gca ect 163 Thr Leu Arg Gly Arg He Ser Thr Val Asp Wing Wing Lys Wing Wing Pro 10 15 20 ccg cca tcg cca cta gcc ccg att gat etc act gac cat agt caa gtg 211 Pro Pro Pro Pro Leu Ala Pro He Asp Leu Thr Asp His Ser Gln Val 25 30 35 gcc ggt gtg atg aat ttg gct gcg aga att ggc gat att ttg ctt tet 259 Wing Gly Val Met Asn Leu Wing Wing Arg He Gly Asp He Leu Leu Ser 40 45 50 tca ggt acg tca aat agt gac acc aag gta caa gtt cga gca gtg acc 307 Ser Gly Thr Ser Asn Ser Asp Thr Lys Val Gln Val Arg Wing Val Thr 55 60 65 tet gcg tac ggt ttg tac tac acg falls gtg gat ate acg ttg aat acg 355 Be Wing Tyr Gly Leu Tyr Tyr Thr His Val Asp He Thr Leu Asn Thr 70 75 80 85 ate acc ate ttc acc aac ate ggt gtg gag agg aag atg ccg gtc aac 403 He Thr He Phe Thr Asn He Gly Val Glu Arg Lys Met Pro Val Asn 90 95 100 gtg ttt cat gtt gta ggc aag ttg gac acc aac ttc tcc aaa ctg tet 451 Val Phe His Val Val Gly Lys Leu Asp Thr Asn Phe Ser Lys Leu Ser 105 110 115 gag gtt gac cgt ttg ate cgt tcc att cag gct ggt gcg acc ccg ect 499 Glu Val Asp Arg Leu He Arg Be He Gln Wing Gly Wing Thr Pro Pro 120 125 130 gag gtt gcc gag aaa ate ctg gac gag ttg gag caa tcc ect gcg tet 547 Glu Val Wing Glu Lys He Leu Asp Glu Leu Glu Gln Ser Pro Wing Ser 135 140 145 tat ggt ttc ect gtt gcg ttg ctt ggc tgg gca atg atg ggt ggt gct 595 Tyr Gly Phe Pro Val Wing Leu Leu Gly Trp Wing Met Met Gly Gly Wing 150 155 160 165 gtt gtg gtg ctg gt gt gt ggt ggg tgg cag gtt tcc cta att gct ttt 643 Val Ala Val Leu Leu Gly Gly Gly Trp Gln Val Ser Leu He Wing Phe 170 175 180 att acc gcg ttc acg ate att gcc acg acg tca ttt ttg gga aag aag 691 He Thr Wing Phe Thr He He Wing Thr Thr Ser Phe Leu Gly Lys Lys 185 190 195 ggt ttg ect act ttc ttc caa aat gtt gtt ggt gtt ttt att gcc acg 739 Gly Leu Pro Thr Phe Phe Gln Asn Val Val Gly Gly Phe He Wing Thr 200 205 210 ctg ect gca tcg att gct tat tet ttg gcg ttg caa ttt ggt ctt gag 787 Leu Pro Wing Being Wing Tyr Being Leu Wing Leu Gln Phe Gly Leu Glu 215 220 225 Tying a ccg age cag ate ate gca tet gga att gtt gtg ctg ttg gca 835 He Lys Pro Ser Gln He He Wing Ser Gly He Val Val Leu Leu Wing 230 235 240 245 ggt ttg here etc gtg caa tet ctg cag gac ggc ate acg ggc gct ccg 883 Gly Leu Thr Leu Val Gln Ser Leu Gln Asp Gly He Thr Gly Wing Pro 250 255 260 gtg here gca agt gca cga ttt ttc gaa here etc ctg ttt acc ggc ggc 931 Val Thr Wing Being Wing Arg Phe Phe Glu Thr Leu Leu Phe Thr Gly Gly 265 270 275 att gtt ggc gtg ggt ttg ggc att cag ctt tet gaa ate ttg cat 979 He Val Wing Gly Val Gly Leu Gly He Gln Leu Ser Glu He Leu His 280 285 290 gtc atg ttg ect gcc atg gag tcc gct gca gca ect aat tat tcg tet 1027 Val Met Leu Pro Wing Met Glu Wing Wing Wing Pro Asn Tyr Ser Ser 295 300 305 here tcc gcc cgc att ate gct ggt ggc gtc acc gca gcg gcc ttc gca 1075 Í ft-t. J it_, a.Í,; :. » . .l l .i -J., Thr Phe Wing Arg He He Wing Gly Gly Val Thr Wing Wing Wing Phe Wing 310 315 320 325 gtg ggt tgt tac gcg gag tgg tcc tcg gtg att att gcg ggg ctt act 1123 Val Gly Cys Tyr Wing Glu Trp Ser Ser Val He He Wing Gly Leu Thr 330 335 340 gcg ctg atg ggt tet gcg ttt tat tac etc ttc gtt gtt tat tta ggc 1171 Wing Leu Met Gly Ser Wing Phe Tyr Tyr Leu Phe Val Val Tyr Leu Gly 345 350 355 ccc gtc tet gcc gct gcg att gct gca here gca gtt ggt ttc act ggt 1219 • Pro Val Wing Wing Wing Wing Wing Wing Thr Wing Val Gly Phe Thr Gly 360 365 370 ggt ttg ctt gcc cgt cga ttc ttg att cca ccg ttg att gtg gcg att 1267 Gly Leu Leu Wing Arg Arg Phe Leu He Pro Pro Leu He Val Wing He 375 380 385 gcc ggc ate here cca atg ctt cca ggt cta gca att tac cgc gga atg 1315 Wing Gly He Thr Pro Met Leu Pro Gly Leu Wing He Tyr Arg Gly Met 390 395 400 405 Tac Gcc Acc Catch Gather here atg ggt ttc acc aac att gcg 1363 Tyr Wing Thr Leu Asn Asp Gln Thr Leu Met Gly Phe Thr Asn He Wing 410 415 420 10 gtt gct tta gcc act gct tca tca ctt gcc gct ggc gtg gtt ttg ggt 1411 Val Ala Leu Ala Thr Ala Ser Ser Leu Ala Ala Gly Val Val Leu Gly 425 430 435 gag tgg att gcc cgc agg cta cgt cgt cca cca cgc ttc aac cca tac 1459 Glu Trp He Wing Arg Arg Leu Arg Arg Pro Pro Arg Phe Asn Pro Tyr 440 445 450 cgt gca ttt acc aag gcg aat gag ttc tcc tcc cag gag gaa gct gag 1507 Arg Ala Phe Thr Lys Ala Asn Glu Phe Ser Phe Gln Glu Glu Ala Glu 455 460 465 cag aat cag cgc cgg cag aga aaa cgt cca aag act aat cag aga ttc 1555 Gln Asn Gln Arg Arg Gln Arg Lys Arg Pro Lys Thr Asn Gln Arg Phe 470 475 480 485 15 ggt aat aaa agg taaaaatcaa cctgcttagg cgt 1590 Gly Asn Lys Arg < 210 > 558 < 211 > 489 < 212 > PRT < 213 > Corynebacterium glutamicum • < 400 > 558 Met Leu Ser Phe Wing Thr Leu Arg Gly Arg He Ser Thr Val Asp Wing 1 5 10 15 20 Wing Lys Wing Wing Pro Pro Pro Wing Pro Pro Leu Wing Pro He Asp Leu Thr 20 25 30 Asp His Ser Gln Val Wing Gly Val Met Asn Leu Ala Ala Arg He Gly 35 40 45 Asp He Leu Leu Ser Ser Gly Thr Ser Asn Ser Asp Thr Lys Val Gln 50 55 60 Val Arg Wing Val Thr Ser Wing Tyr Gly Leu Tyr Tyr Thr His Val Asp 65 70 75 80 He Thr Leu Asn Thr He Thr He Phe Thr Asn He Gly Val Glu Arg 85 90 95 Lys Met Pro Val Asn Val Phe His Val Val Gly Lys Leu Asp Thr Asn 100 105 110 25 Phe Ser Lys Leu Ser Glu Val Asp Arg Leu He Arg Ser He Gln Ala ítí n? r »i. ^ .1," Jan, ti? 115 120 125 Gly Wing Thr Pro Pro Glu Val Wing Glu Lys He Leu Asp Glu Leu Glu 130 135 140 Gln Ser Pro Wing Ser Tyr Gly Phe Pro Val Wing Ala Leu Gly Trp Ala 145 150 155 160 Met Met Gly Gly Ala Val Ala Val Leu Leu Gly Gly Gly Trp Gln Val 165 170 175 Being Leu He Wing Phe He Thr Wing Phe Thr He He Wing Thr Thr Ser 180 185 190 Phe Leu Gly Lys Lys Gly Leu Pro Thr Phe Gln Asn Val Val Gly 195 200 205 Gly Phe He Wing Thr Leu Pro Wing Being He Wing Tyr Ser Leu Ala Leu 210 215 220 Gln Phe Gly Leu Glu He Lys Pro Ser Gln He He Wing Ser Gly He 225 230 235 240 Val Val Leu Leu Ala Gly Leu Thr Leu Val Gln Ser Leu Gln Asp Gly 245 250 255 He Thr Gly Wing Pro Val Thr Wing Being Wing Arg Phe Phe Glu Thr Leu 260 265 270 Leu Phe Thr Gly Gly He Val Wing Gly Val Gly Leu Gly He Gln Leu 275 280 285 Ser Glu He Leu His Val Met Leu Pro Ala Met Glu Be Wing Wing Wing 290 295 300 Pro Asn Tyr Be Ser Thr Phe Wing Arg He He Wing Gly Gly Val Thr 305 310 315 320 Ala Ala Ala Phe Ala Val Gly Cys Tyr Ala Glu Trp Ser Ser Val He 325 330 335 He Wing Wing Gly Leu Thr Wing Wing Le Gou Wing Being Wing Phe Tyr Tyr Leu Phe 340 345 350 Val Val Tyr Leu Gly Pro Val Wing Wing Wing Wing Wing Wing Thr Wing 355 360 365 Val Gly Phe Thr Gly Leu Leu Wing Arg Arg Phe Leu He Pro Pro 370 375 380 Leu He Val Wing He Wing Gly He Thr Pro Met Leu Pro Gly Leu Wing 385 390 395 400 He Tyr Arg Gly Met Tyr Wing Thr Leu Asn Asp Gln Thr Leu Met Gly 405 410 415 Phe Thr Asn He Wing Val Wing Leu Wing Thr Wing Being Ser Leu Wing Wing 420 425 430 Gly Val Val Leu Gly Glu Trp He Wing Arg Arg Leu Arg Ar Pro Pro 435 440 445 Arg Phe Asn Pro Tyr Arg Wing Phe Thr Lys Wing Asn Glu Phe Ser Phe 450 455 460 Gln Glu Glu Wing Glu Gln Asn Gln Arg Arg Gln Arg Lys Arg Pro Lys 465 470 475 480 Thr Asn Gln Arg Phe Gly Asn Lys Arg 485 < 210 > 559 < 211 > 492 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (469) < 223 > RXN03095 ii ?? Sk.r, .ÍJ? Í? ^ -J_ < 400 > 559 aacgcctcaa ttagtgccag accttgccga ccgcagacca aacttcacca tttcaaacca 60 tccctagcca caacaacggc agttgtgcaa tgatctgcgt atg aat gca gat aag 115 Met Asn Wing Asp Lys 1 5 aaa atg tgc gga atg aac ccg gat age caa tac gtc gaa ctt gcc gtc 163 Lys Met Cys Gly Met Asn Pro Asp Ser Gln Tyr Val Glu Leu Ala Val 10 15 20 • gaa gtt ttc gga etc etc gcg gac gcc act cga gtt cgc ate ate ttg 211 Glu Val Phe Gly Leu Leu Wing Asp Wing Thr Arg Val Arg He He Leu 25 30 35 gca ctt cga aac agt ggt gaa ctt tcc gta aac falls etc gcg gac ate 259 Wing Leu Arg Asn Ser Gly Glu Leu Ser Val Asn His Leu Wing Asp He 40 45 50 gtc gat aaa tcc ccc gca gca gtt tcc caa drops etc gcc cgg cgc cgc 307 Val Asp Lys Ser Pro Wing Wing Val Ser Gln His Leu Wing Arg Leu Arg 55 60 65 atg gcc cga ate gtg tcc acc cgt caa gaa ggt caa cga gtt tcc tac 355 Met Wing Arg He Val Ser Thr Arg Gln Glu Gly Gln Arg Val Phe Tyr 10 70 75 80 85 aaa etc acc aat gaa falls gca tca cag cta gtc tcc gac gct att ttt 4Q3 Lys Leu Thr Asn Glu His Ala Ser Gln Leu Val Ser Asp Wing He Phe 90 95 100 • cag gcg gaa falls acc gcg gac ggc cag act ccc cca falls falls falls 451 Gln Ala Glu His Thr He Wing Asp Gly Gln Thr Pro Pro His His His 105 110 115 cga gaa cga gaa caa tca tgaccaccca cagtcaccaa gaa 492 Arg Glu Arg Glu Gln Ser 120 <; 210 > 560 < 211 > 123 15 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 560 Met Asn Wing Asp Lys Lys Met Cys Gly Met Asn Pro Asp Ser Gln Tyr 1 5 10 15 Val Glu Leu Ala Val Glu Val Phe Gly Leu Leu Ala Asp Ala Thr Arg 20 25 30 • Val Arg He He Leu Ala Leu Arg Asn Ser Gly Glu Leu Ser Val Asn 35 40 45 His Leu Wing Asp He Val Asp Lys Ser Pro Wing Wing Val Ser Gln His 20 50 55 60 Leu Wing Arg Leu Arg Met Wing Arg He Val Ser Thr Arg Gln Glu Gly 65 70 75 80 Gln Arg Val Phe Tyr Lys Leu Thr Asn Glu His Wing Gln Leu Val 85 90 95 Ser Asp Wing He Phe Gln Wing Glu His Thr He Wing Asp Gly Gln Thr 100 105 110 Pro Pro His His His Arg Glu Arg Glu Gln Ser 115 120 < 210 > 561 < 211 > 591 < 212 > DNA 25 < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (568) < 223 > RXN03160 < 400 > 561 gagcatatgg tgcgcgcggc cgatatgctg atcaatteca accccgatcc gcacgcttaa 60 • cttctgccaa aaagtcgttt tgaccataag etaagegatt gtg aat cga att gca 115 Val Asn Arg He Wing 1 5 gaa ate gca cgc agt ttc ggc gtg ctg ggc ttc age gct tcc ggc ggc 163 Glu He Ala Arg Ser Phe Gly Val Leu Gly Phe Ser Ala Phe Gly Gly 10 15 20 ccc acc gcg falls etc gga tat tcc cgc acg gaa ttc gtg gag cgg cgg 211 Pro Thr Wing His Leu Gly Tyr Phe Arg Thr Glu Phe Val Glu Arg Arg 25 30 35 cgc tgg ctg gat gat cgc caa tat tcc gag ate gta gcg etc age caa 259 Arg Trp Leu Asp Asp Arg Gln Tyr Ser Glu He Val Ala Leu Ser Gln 40 45 50 10 cta ctt ccc gga ect gga tcg tcg cag gtc atg atg gtc ggc tac 307 Leu Leu Pro Gly Pro Gly Be Ser Gln Val Gly Met Met Leu Gly Tyr 55 60 65 • fall cgc gcc gtt ttt ggc atg gcg ate gcc tgg etc atg ttt acc 355 His Arg Wing Gly Phe Ser Gly Met Wing He Wing Trp Leu Met Phe Thr 70 75 80 85 tgg ccc tca ttg gcg etc atg gcg gcg tcc gcc ctg ctt ttt gat gcg 403 Trp Pro Ser Leu Ala Leu Met Wing Wing Phe Wing Leu Leu Phe Asp Wing 90 95 100 acc tcc gcc age tgg acg etc g gc ctg etc gcc gc gcg gtc gcc gtc 451 Thr Ser Wing Ser Trp Thr Leu Gly Leu Leu Wing Wing Val Wing Val 105 110 115 15 gtt ttc aaa cgc agt drops cgg gca tgg cgc ggt tca atg gct tcc acg 499 Val Phe Lys Arg Ser His Arg Wing Trp Arg Gly Ser Met Wing Ser Thr 120 125 ccc ggg cgc cgg cca cca cca ccc gcg gcc gcc etc ggg ccc gcg cgg ggg 547 Pro Gly Arg Pro Pro Ser Gly Val Gly Leu Gly Ala Ser Arg Val 135 140 145 etc ggc ect ccc caa cgg ggt taacacacct tggggttcaa tca 591 Leu Gly Pro Pro Gln Arg Gly 150 155 < 210 > 562 < 211 > 156 20 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 562 Val Asn Arg He Wing Glu He Wing Arg Being Phe Gly Val Leu Gly Phe 1 5 10 15 Being Wing Phe Gly Gly Pro Thr Wing His Leu Gly Tyr Phe Arg Thr Glu 20 25 30 Phe Val Glu Arg Arg Arg Trp Leu Asp Asp Arg Gln Tyr Ser Glu He 35 40 45 Val Ala Leu Ser Gln Leu Leu Pro Gly Pro Gly Ser Ser Gln Val Gly 25 50 55 60 l * JLA. * mr ?. ~? a? t? , .. 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Met Met Leu Gly Tyr His Arg Wing Gly Phe Ser Gly Met Wing Wing 65 70 75 80 Trp Leu Met Phe Thr Trp Pro Ser Leu Ala Leu Met Wing Wing Phe Wing 85 90 95 Leu Leu Phe Asp Wing Thr Ser Wing Being Trp Thr Leu Gly Leu Leu Wing 100 105 110 Ala Ala Val Ala Val Val Phe Lys Arg Ser His Arg Ala Trp Arg Gly 115 120 125 Ser Met Ala Ser Thr Pro Gly Arg Pro Pro Ser Gly Val Gly Leu • 130 135 140 Gly Ala Ser Arg Val Leu Gly Pro Pro Gln Arg Gly 145 150 155 < 210 > 563 < 211 > 645 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (622) 10 < 223 > RXN02955 < 400 > 563 atgcactggc -tcccatcaaa gacgaattct tgacetcaga attccagcgt < gaactctacg 60 • aagcagtgcg icgccgctgat acttcaggag gtgcggt = atc atg atg aat ttt aag 115 Met Met Asn Phe Lys 1 Ser He Val Cys Val Thr Wing Trp Gln Val Phe Ser Arg Gln Val Leu 10 15 20 falls age cca tca acg tgg tet gaa gaa cta tcc aag ctg ttg ttc gtg 211 His Ser Pro Ser Thr Trp Ser Glu Glu Leu Ser Lys Leu Leu Phe Val 15 25 30 35 tgg cta tet ttc gca ggt agt gcg ttc etc ttt gga gag cgt gga cat 259 Trp Leu Ser Phe Wing Gly Ser Wing Phe Leu Phe Gly Glu Arg Gly His 40 45 50 att gcg gtt gat ttc ate gcg cgc aaa ctg ect gtt tet gcg cag cgg 307 He Wing Val Asp Phe He Wing Arg Lys Leu Pro Val Wing Wing Gln Arg 55 60 65 gtc ctg cag gtc att gtt cag ttg ttg att gtt gtt ttt gcg ate etc 355 Val Leu Gln Val He Val Gln Leu Leu He Val Val Phe Ala He Leu • 70 75 80 85 ggc atg ate tgg ggt ggc tac ttg gct gca tca ate gcg tgg aat cag 403 Gly Met He Trp Gly Gly Tyr Leu Wing Wing Being He Wing Trp Asn Gln 20 90 95 100 cag etc act gcg ctg cca ctt acc ttg gga tgg gtg tat gtt gtc ate 451 Gln Leu Thr Ala Leu Pro Leu Thr Leu Gly Trp Val Tyr Val Val He 105 110 115 ccg ate gcg ggt gtg ttc ate gcg ttg ttc gcg ate ate gat etc ate 499 Pro He Wing Gly Val Phe He Wing Leu Phe Wing He He Asp Leu He 120 125 130 gaa gtg gcc here ggc aag gaa gact ect tac cct ctt gtt gat gaa tca 547 Glu Val Wing Thr Gly Lys Glu Glu Pro Tyr Pro Leu Val Asp Glu Ser 135 140 145 gaa gaa ect cga gat ttg gac gag cta gag gcc caa age gct ata gat 595 Glu Glu Pro Arg Asp Leu Asp Glu Leu Glu Wing Gln Ser Wing He Asp 25 fc »«. **. * n * «t ^,. . .. - ié- Á íáá 150 155 160 165 tet gca agt tca gcg gaa ggt agg aac taatatgttg tcgccagcag 642 Ser Ala Ser Ser Ala Glu Gly Arg Asn 170 ctg 645 < 210 > 564 < 211 > 174 < 212 > PRT • < 213 > Corynebacterium glutamicum < 400 > 564 Met Met Asn Phe Lys Ser He Val Cys Val Thr Wing Trp Gln Val Phe 1 5 10 15 Ser Arg Gln Val Leu His Ser Pro Ser Thr Trp Ser Glu Glu Leu Ser 20 25 30 Lys Leu Leu Phe Val Trp Leu Ser Phe Ala Gly Ser Ala Phe Leu Phe 35 40 45 Gly Glu Arg Gly His He Wing Val Asp Phe He Wing Arg Lys Leu Pro 50 55 60 10 Val Ser Wing Gln Arg Val Leu Gln Val He Val Gln Leu Leu He Val 65 70 75 80 Val Phe Wing He Leu Gly Met He Trp Gly Gly Tyr Leu Wing Wing Ser 85 90 95 • He Wing Trp Asn Gln Gln Leu Thr Wing Leu Pro Leu Thr Leu Gly Trp 100 105 110 Val Tyr Val Val He Pro He Wing Gly Val Phe He Ala Leu Phe Wing 115 120 125 He He Asp Leu He Glu Val Wing Thr Gly Lys Glu Glu Pro Tyr Pro 130 135 140 Leu Val Asp Glu Ser Glu Glu Pro Arg Asp Leu Asp Glu Leu Glu Wing 145 150 155 160 15 Gln Ser Ala He Asp Being Wing Being Ser Glu Wing Gly Arg Asn 165 170 < 210 > 565 < 211 > 754 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > • < 221 > CDS < 222 > (101) .. (754) < 223 > RXN03109 20 < 400 > 565 actggegett cccgatggtc aatcattggc ctttggtgcc caaactggcg agttgttgct 60 ccgcgcatcc cgcgaactgt atgtgcaggg cggcgagtag atg gtt gtg aag gag 115 Met Val Val Lys Glu 1 5 gtt gac gtc gaa aag caa aaa gct ggc cgg gtg ect ggt gct ata gct 163 Val Asp Val Glu Lys Gln Lys Ala Gly Arg Val Pro Gly Wing He Wing 10 15 20 aag cgt cgg cgt ggg cgg gtg ctg gtg ctg gtc gcg ctg ggc gcg ate 211 Lys Arg Arg Thr Val Arg He Val Leu Phe Val Ala Leu Gly Ala He 25 30 35 25 gtg att gcg gcg tcg ctg tgg tcg att ctg gtc ggc caa tac acc ate 259 ? HkaL.A.ááA **,! .. *** Val He Wing Wing Ser Leu Trp Ser He Leu Val Gly Gln Tyr Thr He 40 45 50 ccg att cgc gat cta ect gcg att tta gcc tcc ggt ccg acc ggt gcg 307 Pro He Arg Asp Leu Pro Ala He Leu Wing Ser Gly Pro Thr Gly Wing 55 60 65 cag acg atg gcg gaa cat gtc gtg tgg caa ate cgc atg ccg cgc ate 355 Gln Thr Met Wing Glu Gln Val Val Trp Gln He Arg Met Pro Arg He 70 75 80 85 gtg ctg gga ctg etc gtg ggt gcc gct gct ggc ggc ggc ggc gcg ctg 403 Val Leu Gly Leu Leu Val Gly Ala Wing Leu Gly Val Wing Ala Gly Wing 95 95 100 ttg cag gcg gtg ttt tcc aac ccg ctg gcg gaa ccg tcg ate ate ggc 451 Leu Gln Wing Val Phe Ser Asn Pro Leu Wing Glu Pro Ser He He Gly 105 110 115 gtg acc tcc ggc gcg ggc gtg ggt gct gct gcg gtg ate gtg ttt aac 499 Val Thr Ser Gly Wing Gly Val Gly Ala Wing Ala Val He Val Phe Asn 120 125 130 ctg here ttt ttg ggc here tcc gtc acc gtc gcc gcg ttt att acc 547 Leu Thr Phe Leu Gly Thr Ser Thr Val Wing Val Gly Wing Phe He Thr 135 140 145 10 gcg gtg ate acc acg att ttg gta tat cag ctg gcc aga age cgt gga 595 Wing Val He Thr Thr He Leu Val Tyr Gln Leu Wing Arg Ser Arg Gly 150 155 160 165 cgt gtg caa gtg ate aac ctg ate ctg here ggc ata gcc att aat gca 643 • Arg Val Gln Val He Asn Leu He Leu Thr Gly He Wing He Asn Wing 170 175 180 gta tc ggc gcg ctg acc tca gtt ctt cat cat cat cgc gcc gac gag 691 Val Ser Gly Ala Leu Thr Ser Val Leu Asp Leu His Arg Wing Asp Glu 185 190 195 etc ccg cga aga aat att ttc tgc aga tgg gtt ect cae ggc tcg cat 739 Leu Pro Arg Arg Asn He Phe Cys Arg Trp Val Pro His Gly Ser His 200 205 210 15 ggc gca cgt caa cgt 754 Gly Ala Arg Gln Arg 215 < 210 > 566 < 211 > 218 < 212 > PRT < 213 > Corynebacterium glutamicum • < 400 > 566 Met Val Val Lys Glu Val Asp Val Glu Lys Gln Lys Wing Gly Arg Val 1 5 10 15 20 Pro Gly Wing He Wing Lys Arg Arg Thr Val Arg He Val Leu Phe Val 20 25 30 Wing Leu Gly Wing He Val Wing Wing Wing Being Leu Trp Being He Leu Val 35 40 45 Gly Gln Tyr Thr He Pro He Arg Asp Leu Pro Wing He Leu Wing Being 50 55 60 Gly Pro Thr Gly Wing Gln Thr Met Wing Glu Gln Val Val Trp Gln He 65 70 75 80 Arg Met Pro Arg He Val Leu Gly Leu Leu Val Gly Ala Wing Leu Gly 85 90 95 Val Wing Gly Wing Leu Leu Gln Wing Val Phe Ser Asn Pro Leu Wing Glu 100 105 110 25 Pro Ser He He Gly Val Thr Ser Gly Wing Gly Val Gly Ala Ala Ala 115 120 125 Val He Val Phe Asn Leu Thr Phe Leu Gly Thr Ser Thr Val Wing Val 130 135 140 Gly Wing Phe He Thr Wing Val He Thr Thr He Leu Val Tyr Gln Leu 145 150 155 160 Wing Arg Being Arg Gly Arg Val Gln Val He Asn Leu He Leu Thr Gly 165 170 175 He Wing He Asn Wing Val Ser Gly Wing Leu Thr Ser Val Leu Asp Leu 180 185 190 His Arg Wing Asp Glu Leu Pro Arg Arg Asn He Phe Cys Arg Trp Val 195 200 205 Pro His Gly Ser His Gly Ala Arg Gln Arg 210 215 < 210 > 567 < 211 > 357 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS 10 < 222 > (101) .. (334) < 223 > RXN02979 < 400 > 567 ctaggtcaag gaaetteact cggctagtcc ttagaetcaa atgtgttcag acaaacactg 60 gcaccgtaag gcacgaaagt taccgaaagg actggttccc atg acc gcc cca aac 115 Met Thr Ala Pro Asn 1 5 act etc aag caa here act ctt cgc tet gat gag ttc tet tgc cca tcc 163 Thr Leu Lys Gln Thr Thr Leu Arg Be Asp Glu Phe Be Cys Pro Ser 10 15 20 j- tgt gtc tcc aag att gaa aac aaa ttg aat gga ttg gat ggc gtc gac 211 Cys Val Ser Lys He Glu Asn Lys Leu Asn Gly Leu Asp Gly Val Asp 25 30 35 aat gca gag gtg aag ttc tcc tcc gga aga ate ctt gtt gat cae gac 259 Asn Wing Glu Val Lys Phe Ser Gly Arg He Leu Val Asp His Asp 40 45 50 ccc age aag gtc tet ate aag gat gta gtc gct gca gtc gca gag gtt 307 Pro Ser Lys Val Ser He Lys Asp Leu Val Ala Ala Val Wing Glu Val 55 60 65 ggc tac acc gca aag cca tca gca ate taaaactctc agttagacca 354 Gly Tyr Thr Ala Lys Pro Ser Ala He 70 75 tta 357 0 < 210 > 568 < 211 > 78 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 568 Met Thr Ala Pro Asn Thr Leu Lys Gln Thr Thr Leu Arg Ser Asp Glu 1 5 10 15 Phe Ser Cys Pro Ser Cys Val Ser Lys He Glu Asn Lys Leu Asn Gly 20 25 30 Leu Asp Gly Val Asp Asn Ala Glu Val Lys Phe Ser Ser Gly Arg He 5 k b ** ?? * Ahj 35 40 45 Leu Val Asp His Asp Pro Ser Lys Val Ser He Lys Asp Leu Val Wing 50 55 60 Wing Val Wing Glu Val Gly Tyr Thr Wing Lys Pro Ser Wing He 65 70 75 < 210 > 569 < 211 > 357 < 212 > DNA • < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (334) < 223 > RXN02987 < 400 > 569 gttgtttgat ccaggtcaag gaattaaece ggaaaggacc gtatctttaa a ggtgcaagc 60 acaggaacat gacgataaaa gatgaaagga cctggttacg atg acc gcc ccc gcc 115 Met Thr Wing Pro Wing 10 1 5 acg ctg aag aac acc acc ttg cgc tet gat gag ttc acc tgt ccg age 163 Thr Leu Lys Asn Thr Thr Leu Arg Ser Asp Glu Phe Thr Cys Pro Ser 10 15 20 • tgt gtc gcc aag ate gaa aac aag gt ttg gac ggc gtg gag 211 Cys Val Ala Lys He Glu Asn Lys Leu Asn Gly Leu Asp Gly Val Glu 25 30 35 aat gcg gag gtg aag ttc tcc tcc gga cgc ate ctg ate acc falls gac 259 Asn Wing Glu Val Lys Phe Ser Ser Gly Arg He Leu He Thr His Asp 40 45 50 cca cag aag gtc tcc gta cgt gac ctg gtc acc gcg gta gcc gag gtc 307 Pro Gln Lys Val Ser Val Arg Asp Leu Val Thr Ala Val Ala Glu Val 15 55 60 65 ggt tac acc gcc aag ccg tcg gcg ate tgacgcactc ccgaccccac 354 Gly Tyr Thr Ala Lys Pro Ser Ala He 70 75 aag 357 < 210 > 570 < 211 > 78 < 212 > PRT < 213 > Corynebacterium glutam cum < 400 > 570 20 Met Thr Ala Pro Wing Thr Leu Lys Asn Thr Thr Leu Arg Ser Asp Glu 1 5 10 15 Phe Thr Cys Pro Ser Cys Val Wing Lys He Glu Asn Lys Leu Asn Gly 20 25 30 Leu Asp Gly Val Glu Asn Ala Glu Val Lys Phe Ser Ser Gly Arg He 35 40 45 Leu He Thr His Asp Pro Gln Lys Val Ser Val Arg Asp Leu Val Thr 50 55 60 Wing Val Wing Glu Val Gly Tyr Thr Wing Lys Pro Ser Wing He 65 70 75 < 210 > 571 25 < 211 > 1041 L? *? to*? fat ^ fc ^. < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1018) < 223 > RXN03084 < 400 > 571 ccacccccac gtctaagttt tcccctattt acacacacct gaccgaagct gtaaggtttg 60 cctaatcttt ttcaatctaa agtcaggata ttcacagccc atg tca tet cgc aga 115 Met ser ser arg arg 1 5 aaa etc tcc tcc tc gca ctg ate gtg ctt etc gca gca gca cta ect ctt 163 Lys Leu Ser Ser Ala Leu He Val Leu Leu Ala Ala Ala Leu Pro Leu 10 15 20 act gct tgt tcc tcc age tca gaa gag gaa gca tcc acc age tet gcg 211 Thr Ala Cys Ser Being Ser Glu Glu Glu Wing Being Thr Ser Wing 25 30 35 act cgc gaa ttc here gac gct drops gga here acc gaa gtt ccc gaa aat 259 Thr Arg Glu Phe Thr Asp Ala His Gly Thr Thr Glu Val Pro Glu Asn 40 45 50 ect cag cgc gtc gtt gtc etc gag cca ctt gag cta gac acc gca ate 307 Pro Gln Arg Val Val Leu Glu Pro Leu Glu Leu Asp Thr Ala He 55 60 65 gcc gga et gca gtg acc gca gtg gca gct gtc gcc aac aac aac gtc act 355 Wing Leu Gly He Thr Pro Val Gly Wing Wing Val Wing Asn Asn Val Thr 70 75 80 85 ggt att ect gca tat etc ggc gtc gat gga ate gag ect gtc ggc acc 403 Gly He Pro Wing Tyr Leu Gly Val Asp Gly He Glu Pro Val Gly Thr 90 95 100 gtt tet gag cca aat ate gaa gcg gct ate gct gct etc gag ccc gac ctg 451 Val Ser Glu Pro Asn He Glu Ala He Ala Wing Leu Glu Pro Asp Leu 105 110 115 ate ctg ggc acc gat tcc cgc falls gcc gaa ate tac gac cgc etc gaa 499 He Leu Gly Thr Asp Ser Arg His Wing Glu He Tyr Asp Arg Leu Glu 120 125 130 tcc ate gcc cca acc gtg ttc atg here ac cat gtt gat ccg tgg aaa 547 Se r He Ala Pro Thr Val Phe Met Thr Thr His Val Asp Pro Trp Lys 135 140 145 gac aat gtc gtc ttc ate ggc gat gca ttg ggc aag aag cag gaa tcc 595 Asp Asn Val Val Phe He Gly Asp Ala Leu Gly Lys Lys Gln Glu Ser 150 155 160 165 gag gat etc ate caa ggc ttt aat gac aag tgc gaa gag ate aag tcc 643 Glu Asp Leu He Gln Gly Phe Asn Asp Lys Cys Glu Glu He Lys Ser 170 175 180 gag cat gat gtc gaa ggt aag acc gtc aac atg att cgt ccc cgc gac 691 Glu His Asp Val Glu Gly Lys Thr Val Asn Met He Arg Pro Arg Asp 185 190 195 gag caa acc atg age cta tac ggc ccg acc tca ttt gcc ggc age tet 739 Glu Gln Thr Met Ser Leu Tyr Gly Pro Thr Ser Phe Wing Gly Ser Ser 200 205 210 ttg gag tgc gca gga etc acc att ect gat cag gaa tgg aag gat gac 787 Leu Glu Cys Wing Gly Leu Thr He Pro Asp Gln Glu Trp Lys Asp Asp 215 220 225 etc cag gcc gac ate gct ect gag aac ttc atg etc gcc acc gcc gac 835 Leu Gln Wing Asp He Wing Pro Glu Asn Phe Met Leu Wing Thr Wing Asp 230 235 240 245 tac gtc ttt gtc acc gca act gat gtc acc gat gaa aat gag etc ccc 883 Tyr Val Phe Val Thr Wing Thr Asp Val Thr Asp Glu Asn Glu Leu Pro 250 255 260 gaa gta ate cga gaa aac cgc gaa cag ttc cca tca etc acc ctt gtc 931 Glu Val He Arg Glu Asn Arg Glu Gln Phe Pro Ser Leu Thr Leu Val 265 270 275 gat acc age tac tgg gta tet ggc gtc ggt cca ctt ggc ggc age aaa 979 Asp Thr Ser Tyr Trp Val Ser Gly Val Gly Pro Leu Gly Gly Ser Lys 280 285 290 gtc ttg gaa gac ate gat gcc ttc etc gac gca cag caa taatgtccac 1028 Val Leu Glu Asp He Asp Wing Phe Leu Asp Wing Gln Gln 295 300 305 agctctcccc gat 1041 < 210 > 572 < 211 > 306 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 572 Met Being Ser Arg Arg Lys Leu Ser Being Ala Leu He Val Leu Leu Ala 1 5 10 15 Wing Wing Leu Pro Leu Thr Wing Cys Being Ser Glu Glu Glu Wing 20 25 30 Being Thr Being Being Wing Thr Arg Glu Phe Thr Asp Wing His Gly Thr Thr 35 40 45 Glu Val Pro Glu Asn Pro Gln Arg Val Val Val Leu Glu Pro Leu Glu 50 55 60 Leu Asp Thr Ala He Ala Leu Gly He Thr Pro Val Gly Ala Ala Val 65 70 75 80 Wing Asn Asn Val Thr Gly He Pro Wing Tyr Leu Gly Val Asp Gly He 85 90 95 Glu Pro Val Gly Thr Val Ser Glu Pro Asn He Glu Wing He Wing Wing 100 105 110 Leu Glu Pro Asp Leu He Leu Gly Thr Asp Ser Arg His Wing Glu He 115 120 125 Tyr Asp Arg Leu Glu Ser He Wing Pro Thr Val Phe Met Thr Thr His 130 135 140 Val Asp Pro Trp Lys Asp Asn Val Val Phe He Gly Asp Ala Leu Gly 145 150 155 160 Lys Lys Gln Glu Ser Glu Asp Leu He Gln Gly Phe Asn Lys Cys 165 170 175 Glu Glu He Lys Ser Glu His Asp Val Glu Gly Lys Thr Val Asn Met 180 185 190 He Arg Pro Arg Asp Glu Gln Thr Met Ser Leu Tyr Gly Pro Thr Ser 195 200 205 Phe Wing Gly Ser Ser Leu Glu Cys Wing Gly Leu Thr He Pro Asp Gln 210 215 220 Glu Trp Lys Asp Asp Leu Gln Wing Asp He Wing Pro Glu Asn Phe Met 225 225 235 240 Leu Wing Thr Wing Asp Tyr Val Phe Val Thr Wing Thr Asp Val Thr Asp 245 250 255 Glu Asn Glu Leu Pro Glu Val He Arg Glu Asn Arg Glu Gln Phe Pro 260 265 270 Ser Leu Thr Leu Val Asp Thr Ser Tyr Trp Val Ser Gly Val Gly Pro 27 5 280 285 - ~ * Leu Gly Gly Ser Lys Val Leu Glu Asp He Asp Wing Phe Leu Asp Wing 290 295 300 Gln Gln 305 < 210 > 573 < 211 > 440 < 212 > DNA < 213 > Corynebactm glutamicum < 220 > < 221 > CDS < 222 > (1) .. (417!) < 223 > RXN03183 < 400 > 573 gaa gcc gaa gca acc gca ggc aaa ttc gaa gta cag ccc etc gta ggt 48 Glu Ala Glu Ala Thr Ala Gly Lys Phe Glu Val Gln Pro Leu Val Gly 1 5 10 15 aaa gac ggc gtc ggc gta tcc acc ctt ggt ggc tac aac aac ggc ate 96 Lys Asp Gly Val Gly Val Ser Thr Leu Gly Gly Tyr Asn Asn Gly He 20 25 30 aac gtc aac tcc gaa aac aag gca acc gcc cgc gac ttc ate gaa ttc 144 Asn Val Asn Ser Glu Asn Lys Wing Thr Wing Arg Asp Phe He Glu Phe 35 40 45 ate ate aac gaa gag aac caa acc tgg ttc gcg gac aac tcc ttc cca 192 He He As Asn Glu Glu Asn Gln Thr Trp Phe Wing Asp Asn Ser Phe Pro 50 55 60 cca gtt ctg gca tcc ate tac gat gat gag tcc ctt gtt gag cag tac 240 Pro Val Leu Ala Ser He Tyr Asp Asp Glu Ser Leu Val Glu Gln Tyr 65 70 75 80 cca tac ctg cca gca ctg aag gaa tcc ctg gaa aac gca gca cca cgc 288 Pro Tyr Leu Pro Wing Leu Lys Glu Ser Leu Glu Asn Ala Wing Pro Arg 85 90 95 cca gtg tet ect ttc tac cca gcc ate tcc aag gca ate cag gac aac 336 Pro Val Ser Pro Phe Tyr Pro Wing He Ser Lys Wing He Gln Asp Asn 100 105 110 gcc tac gca gcg ctt aac ggc aac gtc gac gtt gac cag gca acc acc 384 Wing Tyr Wing Wing Leu Asn Gly Asn Val Asp Val Asp Gln Wing Thr Thr 115 120 125 gat atg aag gca gcg ate gaa aac gct tcc age tagt -.tcggta atttagttca 437 Asp Met Lys Ala Ala He Glu Asn Ala Ser Ser 130 135 ttc 440 < 210 > 574 < 211 > 139 < 212 > PRT < 213 > Corynebactm glutamicum < 400 > 574 Glu Ala Glu Ala Thr Ala Gly Lys Phe Glu Val Gln Pro Leu Val Gly 1 5 10 15 Lys Asp Gly Val Gly Val Ser Thr Leu Gly Gly Tyr Asn Asn Gly He 20 25 30 Asn Val Asn Ser Glu Asn Lys Wing Thr Wing Arg Asp Phe He Glu Phe 35 40 45 - * fe- "He He Asn Glu Glu Asn Gln Thr Trp Phe Wing Asp Asn Ser Phe Pro 50 55 60 Pro Val Leu Wing Ser He Tyr Asp Asp Glu Ser Leu Val Glu Gln Tyr 65 70 75 80 Pro Tyr Leu Pro Ala Leu Lys Glu Ser Leu Glu Asn Wing Wing Pro Arg 85 90 95 Pro Val Ser Pro Phe Tyr Pro Wing He Ser Lys Wing He Gln Asp Asn 100 105 110 Wing Tyr Wing Wing Leu Asn Gly Asn Val Asp Val Asp Gln Wing Thr Thr • 115 120 125 Asp Met Lys Ala Ala He Glu Asn Ala Ser Ser 130 135 < 210 > 575 < 211 > 1077 < 212 > DNA < 213 > Corynebactm glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1054; 10 <223> RXN0H39 <400> 575 • accaccgtgg tcaggettttt cagtggcaatg aatgattaatt ctccacccct 1tcattttcaa 60 taa <gctttca; ataat? Ggg¡ag aagtgtgctt agctggggtc atg gaa age cae gat 115 Met Glu Ser His Asp 1 5 ctt cag cag cgc agt tat gcg falls aat ccc gat ggc falls gac falls age 163 Leu Gln Gln Arg Ser Tyr Wing His Asn Pro Asp Gly His Asp His Ser 10 15 20 cat gac gga etc gga drops tca cat gct ccc age tcc etc aag gct ctt 211 His Asp Gly Leu Gly His Ser His Wing Pro Ser Ser Leu Lys Ala Leu 15 25 30 35 ttt gcg gtc ate att ttc acc tcg ate ate ttc cta gcg gaa cta ate 259 Phe Wing Val He He Phe Thr Ser He He Phe Leu Wing Glu Leu He 40 45 50 gcc ggc ctt att tc gga gt ttg gca ctg ctg gct gac gcc atg falls 307 Wing Gly Leu He Ser Gly Ser Leu Wing Leu Leu Wing Asp Wing Met His 55 60 65 atg ctg tcc gac tcc act ggc ttg ate att gcg gct gtc gcc atg etc 355 • Met Leu Ser Asp Be Thr Gly Leu He He Wing Wing Val Wing Met Leu 70 75 80 85 att ggc cgt cgg gca cgc act tet cgt gcg acc tac gga tac aag cgt 403 Thr Tyr Gly Tyr Lys Arg 20 He Gly Arg Arg Ala Arg Thr Ser Arg Wing 90 95 100 gcg gaa gtc ttg gca gcg atg gtt aac gcc acc gtt gtt here gca ctg 451 Ala Glu Val Leu Ala Ala Met Val Asn Ala Thr Val Val Thr Ala Leu 105 110 115 tet gtg tgg ate gtc gtt gag gcc ate atg cgt ctg ggc aag gac ctg 499 Ser Val Trp He Val Val Glu Ala He Met Arg Leu Gly Lys Asp Leu 120 125 130 gaa ate cag acc aac ctg atg etc ate gtc gcg gtc att ggt ttt gtc 547 Glu He Gln Thr Asn Leu Met Leu He Val Wing Val He Gly Phe Val 135 140 145 acc aac gga att tcc gcc ctg gtg ttg atg cgc cae caa gat ggc aat 595 25 Thr Asn Gly He Be Wing Leu Val Leu Met Arg His Gln Asp Gly Asn ^^ ¡^ • "* - - '" - ** • * "* * *' * • 150 155 160 165 ate aat atg cgt gga gca ttc ctt falls gtt etc agt gac atg ctg ggt 643 He Asn Met Arg Gly Ala Phe Leu His Val Leu Ser Asp Met Leu Gly 170 175 180 tcc gtt gcc gtc att att gcg ggc ctg gtg att cgc tac acg gga tgg 691 Ser Val Ala Val He He Ala Gly Leu Val He Arg Tyr Thr Gly Trp 185 190 195 atg ccg gcc gat acc att gct tcg att gcg att gct gcg att att 739 Met Pro Wing Asp Thr Wing Wing Be Wing Wing Wing Wing He He He • 200 205 210 ect cgc gca ttc age etc ctg aag gaa gct etc aat ate ttg ttg gag 787 Pro Arg Ala Phe Ser Leu Leu Lys Glu Ala Leu Asn He Leu Leu Glu 215 220 225 cgt gtt ect here ggt gcg gag ect gca gag gtc gac gca gcc ctt cgt 835 Arg Val Pro Thr Gly Wing Glu Pro Wing Glu Val Asp Wing Wing Leu Arg 230 235 240 245 aaa gtc cca ggt gtc age gat gtg cat gat ctt fall att tgg age att 883 Lys Val Pro Gly Val Ser Asp Val His Asp Leu His He Trp Ser He 250 255 260 gac ggc aag gaa ate ctg gcc acg gtg cat ttg gtg gtg gat tcg tet 931 Asp Gly Lys Glu He Leu Wing Thr Val 10 His Leu Val Val Asp Ser Ser 265 270 275 here aat cag ctg cat agt tgt ggc gtg ttg gat cgg gca gaa gcg gaa 979 Thr Asn Gln Leu His Ser Cys Gly Val Leu Asp Arg Ala Glu Ala Glu 280 285 290 cta tcc aaa ctt ggg ate ttg falls tca here att cag ctg gaa age gca 1027 Leu Ser Lys Leu Gly He Leu His Ser Thr He Gln Leu Glu Ser Wing 295 300 305 gat falls agt gat cat gaa agt gtg tgc tgatatagag tatgtcccat 1074 Asp His Ser Asp His Glu Ser Val Cys 310 315 ggg 1077 15 < 210 > 576 < 211 > 318 < 212 > PRT < 213 > Corynebact: epum gl .utamicum < 400 > 576 Met Glu Ser His Asp Leu Gln Gln Arg Ser Tyr Ala His Asn Pro Asp 1 5 10 15 • Gly His Asp His Ser His Asp Gly Leu Gly His Ser His Wing Pro Ser 20 25 30 Ser Leu Lys Ala Leu Phe Ala Val He He Phe Thr Ser He He Phe 20 35 40 45 Leu Wing Glu Leu He Wing Gly Leu He Ser Gly Ser Leu Wing Leu Leu 50 55 60 Wing Asp Wing Met His Met Leu Ser Asp Being Thr Gly Leu He He Wing 65 70 75 80 Wing Val Wing Met Leu He Gly Arg Arg Wing Arg Thr Ser Arg Wing Thr 85 90 95 Tyr Gly Tyr Lys Arg Wing Glu Val Leu Wing Wing Met Val Asn Wing Thr 100 105 110 Val Val Thr Wing Leu Ser Val Trp He Val Val Glu Wing He Met Arg 115 120 125 Leu Gly Lys Asp Leu Glu He Gln Thr Asn Leu Met Leu He Val Wing 25 130 135 140 M ^. ^ Fi. j Val He Gly Phe Val Thr Asn Gly He Ser Wing Leu Val Leu Met Arg 145 150 155 160 His Gln Asp Gly Asn He Asn Met Arg Gly Wing Phe Leu His Val Leu 165 170 175 Being Asp Met Leu Gly Ser Val Wing Val He He Wing Gly Leu Val He 180 185 190 Arg Tyr Thr Gly Trp Met Pro Wing Asp Thr He Wing Wing He Wing 195 200 205 Wing Wing He He Pro Arg Wing Phe Ser Leu Leu Lys Glu Wing Leu • 210 215 220 Asn He Leu Leu Glu Arg Val Pro Thr Gly Wing Glu Pro Wing Glu Val 225 230 235 240 Asp Wing Wing Leu Arg Lys Val Pro Gly Val Ser Asp Val His Asp Leu 245 250 255 His He Trp Ser He Asp Gly Lys Glu He Leu Wing Thr Val His Leu 260 265 270 Val Val Asp Ser Ser Thr Asn Gln Leu His Ser Cys Gly Val Leu Asp 275 280 285 Arg Ala Glu Ala Glu Leu Ser Lys Leu Gly He Leu His Ser Thr He 290 295 300 10 Gln Leu Glu Ser Ala Asp His Ser Asp His Glu Ser Val Cys 305 310 315 < 210 > 577 • < 211 > 2733 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (2710) < 223 > RXN00378 15 < 400 > 577 accgtgagcc ttatactgtg aggacattaa aagtgacacc tettttteta tcttttacaa 60 eccaagaagg tttatcgtga gcacaccgga ttcttcctcg gtg gac aag gcc gta 115 Val Asp Lys Ala Val 1 5 aac act gct ate tet gac gcc aaa here gcg gcg etc aag gca ggt gtt 163 Asn Thr Ala He Ser Asp Ala Lys Thr Ala Ala Leu Lys Ala Gly Val 10 15 20 gga ttg aac cga gcc acc gcc tca gaa gaa gag gaa gat tta age tca 211 Gly Leu Asn Arg Ala Thr Ala Ser Glu Glu Glu Glu Asp Leu Ser Ser 25 30 35 20 age att aag gtt tet ttg gcc ttt gag etc gag ggg tta age aat gca 259 Ser He Lys Val Ser Leu Wing Phe Glu Leu Glu Gly Leu Ser Asn Wing 40 45 50 cca tcg ttg atg gtg gtg gaa aaa gcc cta gag aag ate ccc ggt gta 307 Pro Ser Leu Met Val Val Glu Lys Ala Leu Glu Lys He Pro Gly Val 55 60 65 tcc gcg gat ctg att tac ect tca caa act gca tgg att here gca act 355 Be Wing Asp Leu He Tyr Pro Be Gln Thr Wing Trp He Thr Wing Thr 70 75 80 85 gat cgg gta cat ccc gaa acc etc att gag gtg ttt gag cag ttc ggc 403 Asp Arg Val His Pro Glu Thr Leu He Glu Val Phe Glu Gln Phe Gly 90 95 100 25 ate aaa gca falls ctt tet aat tca tcg ctg ctg cgc agg cat caa cag 451 He Lys Ala His Leu Ser Asn Ser Ser Leu Leu Arg Arg His Gln Gln 105 110 115 etc age gcg gaa gta aat agg gaa gca cgc ctt gat cgt tac cgc tcc 499 Leu Ser Wing Glu Val Asn Arg Glu Wing Arg Leu Asp Arg Tyr Arg Ser 120 125 130 cga atg gat gcc aag cga ate tcg ect cgt gtg cga agg cat aac cga 547 Arg Met Asp Ala Lys Arg He Ser Pro Arg Val Arg Arg His Asn Arg 135 140 145 caa gaa atg gta cat gcg gta cgc gct cgt gaa agt ggt tgg att aaa 595 • Gln Glu Met Val His Wing Val Arg Wing Arg Glu Ser Gly Trp He Lys 150 155 160 165 cgc agg aat falls acc acc tcg cag cat gaa gac cca atg tcg ggc gat 643 Arg Arg Asn His Thr Thr Ser Gln His Glu Asp Pro Met Ser Gly Asp 170 175 180 gtg ctg ttc acc gcc cgc gca ctc att here ect aag cgt ttg tgg gtg 691 Val Leu Phe Thr Ala Arg Ala Leu He Thr Pro Lys Arg Leu Trp Val 185 190 195 tcg ttg ccg ttt gcg etc ate gta ttg gcg tta tcg ttg aat ect tcg 739 Ser Leu Pro Phe Ala Leu He Val Leu Ala Leu Ser Leu Asn Pro Ser 200 205 210 tgg cag ttt gat tat tgg cag 787 10 tgg ttg tcc gct gtg ttg gct att ect Trp Gln Phe Asp Tyr Trp Gln Trp Leu Ser Wing Val Leu Wing Pro 215 220 225 gtg gtg gtg tgg ggt gcc tgg ccg ttt fall cgc gct gca gca ggc ggt 835 • Val Val Val Trp Gly Wing Trp Pro Phe His Arg Wing Wing Wing Gly Gly 230 235 240 245 att cgt cga gga att tcc gct ctt gat gcg acc age tca ate gct att 883 He Arg Arg Gly He Ser Wing Leu Asp Wing Thr Ser Be He Wing He 250 255 260 gct gc gc tac gcg tgg tet tet gcc atg ctg ttg ttt gaa acc cca 931 Wing Wing wing Tyr Wing Trp Ser He Wing Met Leu Leu Phe Glu Thr Pro 265 270 275 gga aa tcc gct ttt gac cae 979 15 ggt to tgg cgg tca tat ccg tcc tgg tgc Gly Gly Lys Ser Trp Arg Ser Tyr Pro Ser Trp Phe Wing Phe Asp His 280 285 290 ggc acg ttg acc aac gag att tat ttt gat gtg gcc tgc gga ate 1027 Gly Thr Leu Thr Gln Asn Glu He Tyr Phe Asp Val Wing Cys Gly He 295 300 305 acc gtg ttg ctt ctt ctt gcc ggg cgg ctg here agg cgt cga age caa 1075 Thr Val Leu Leu Leu Wing Gly Arg Leu Leu Thr Arg Arg Arg Ser Gln 310 315 320 325 tcc agt ttg tta gcg gaa ctt ggt cgc etc caa ate gat cca cag cgc 1123 Ser Ser Leu Leu Ala Glu Leu Gly Arg Leu Gln He Asp Pro Gln Arg 330 335 340 att gtc act gtg gtg cgt aaa falls cga ttg aag cgc gta gtc cag gaa 1171 20 He Val Thr Val Val Arg Lys His Arg Leu Lys Arg Val Val Gln Glu 345 350 355 ctg aac att cca gtg cag gaa gtc cgt gtc aat gac gat gtg aaa gtt 1219 Leu Asn He Pro Val Gln Glu Val Arg Val Asn Asp Asp Val Lys Val 360 365 370 cca ect aat acct ate ect g gg gcg act gtc ggc ggc ggc ggt 1267 Pro Pro Asn Thr Thr He Pro Val Asp Gly Thr Val He Gly Gly Gly 375 380 385 tcg cgg ate gca gct age ate ate atg gga caa gac cag cgt gat gta 1315 Ser Arg He Wing Wing He He Met Met Gly Gln Asp Gln Arg Asp Val 390 395 400 405 aaa gta aat gac aaa gtt tcc gcc ggc age etc aac etc gaa tcc gaa 1363 25 Lys Val Asn Asp Lys Val Phe Wing Gly Ser Leu Asn Leu Glu Ser Glu 410 415 420 ate aag gtt cgt gtt att cgc act ggt falls cgc acc cgc ate gcc gcg 1411 He Lys Val Arg Val He Arg Thr Gly His Arg Thr Arg He Ala Ala 425 430 435 gta cat agg tgg gtt aaa gaa gcg acg ttg aag gaa aac cgc falls aat 1459 Val His Arg Trp Val Lys Glu Ala Thr Leu Lys Glu Asn Arg His Asn 440 445 450 agg gca gcg ate cgt tcg gcc ggt aac ctt gtg ccc ate acg ttc acc 1507 Arg Ala Ala He Arg Be Ala Gly Asn Leu Val Pro He Thr Phe Thr 455 460 465 ctt gct gtg gtg gac ttc tgt ctg tgg gca ctg ate tet gga aac ate 1555 Leu Ala Val Val Asp Phe Cys Leu Trp Ala Leu He Ser Gly Asn He 470 475 480 485 aac gct gt ttt acc act acc ttg gct gtc ctt gcg tgc gtg gct gcg 1603 Asn Ala Ala Phe Thr Thr Leu Ala Val Leu Ala Cys Val Ala Pro 490 495 500 gtg gcc tta gcg ttg tet gct cca ctt gcc acg agg aat tcc ate gaa 1651 Val Ala Leu Ala Leu Ser Ala Pro Leu Ala Thr Arg Asn Ser He Glu 505 510 515 gct gca gca gga cga ggt att gtc gtc cgc tet ggt gaa att ttc cga 1699 Ala Ala Ala Arg His Gly He Leu Val Arg Ser Gly Glu He Phe Arg 520 525 530 gtt etc gat gat gtg gat act gcc gta ttt aat cgt gtg ggc here cta 1747 Val Leu Asp Asp Val Asp Thr Ala Val Phe Asn Arg Val Gly Thr Leu 535 540 545 acc gat ggc gaa atg here gtg gaa acc gtc here gca gac aaa ggc gag 1795 Thr Asp Gly Glu Met Thr Val Glu Thr Val Thr Wing Asp Lys Gly Glu 550 555 560 565 gac cca gaa cta gtg ctg cgt gtc gcc ggg gcg ttg gcc atg gaa tcc 1843 Asp Pro Glu Leu Val Leu Arg Val Wing Gl and Ala Leu Ala Met Glu Ser 570 575 580 falls falls gcg att tcc aaa gca ctg gtg aaa gca tcc cgt gaa gct cgt 1891 His His Ala He Be Lys Ala Leu Val Lys Ala Ser Arg Glu Ala Arg 585 590 595 gat acc ggc gcc ggt ggt gaa gat gtc cca falls tgg att gaa gta ggc 1939 Asp Thr Gly Wing Gly Gly Glu Asp Val Pro His Trp He Glu Val Gly 600 605 610 aac gtg gaa ate acc gaa gcc ggc tca ttc caa gca acc ate gag ctg 1987 Asn Val Glu He Thr Glu Ala Gly Ser Phe Gln Ala Thr He Glu Leu 615 620 625 cca ctg ate aaa cca tet ggc gaa aaa ate atg cgc acc here gaa gca 2035 Pro Leu He Lys Pro Be Gly Glu Lys He Met Arg Thr Thr Glu Wing 630 635 640 645 etc ctg tgg cga cca cga ccc tcc atg here gaa gtc cgt gag drops tta age 2083 Leu Leu Trp Arg Pro Arg Ser Met Thr Glu Val Arg Glu His Leu Ser 650 655 660 ccc cga cta gt gca gca gca gca gca gca gca gca gca gca cca cca gtg gtg 2131 Pro Arg Leu Val Ala Ala Ala Thr Ser Gly Gly Ala Pro Leu He Val 665 670 675 cga tgg aaa ggc aaa gac cgc gga gtt ate act cta agt gac falls gtg 2179 Arg Trp Lys Gly Lys Asp Arg Gly Val He Thr Leu Ser Asp His Val 680 685 690 aga tca gat tcc tcc gat gcg att att gcg att gaa gaa caa ggc at e 2227 Arg Ser Asp Ser Ser Asp Ala He He Ala Ala Glu Glu Gln Gly He 695 700 705 gag acc atg ctt tca cgt gat act tac ccg gtg gca cgt cga tac 2275 Glu Thr Met Met Leu Ser Arg Asp Thr Tyr Pro Val Wing Arg Arg Tyr 710 715 720 725 gca gac age tta ggc ate acc fall gtc gtc gtc gcc gcg gcc ccg ggc 2323 Wing Asp Ser Leu Gly He Thr His Val Leu Wing Gly He Wing Pro Gly 730 735 740 aag aaa gcc cag gtc gtc cgt gca gtc falls acc cgc gga tcc act gtc 2371 Lys Lys Ala Gln Val Val Arg Ala Val His Thr Arg Gly Ser Thr Val 745 750 755 gcg atg ate ggc gat gaa tca gta atg gac tgt ttg aaa gtc gct gac 2419 Ala Met He Gly Asp Glu Ser Val Met Asp Cys Leu Lys Val Wing Asp 760 765 770 gtg ggt gta ctg atg ggc gtc gat cgt ccc tca gat ctg cgt gat gat 2467 Val Gly Val Leu Met Gly Val Asp Arg Pro Ser Asp Leu Arg Asp Asp 775 780 785 tcc gat gac ccg gca gct gac gtt gtg gtc atg cgc gaa gag gtc atg 2515 Ser Asp Asp Pro Wing Wing Asp Val Val Val Met Arg Glu Val Glu Val 790 795 800 805 age gtg ccg acg ctg ttt aaa ctg gct cgc cgc tac gcc aag ttg gtc 2563 Ser Val Pro Thr Leu Phe Lys Leu Wing Arg Arg Tyr Wing Lys Leu Val 810 815 820 aat ggc aat att gct ctg gcc tgg ate tat aac ggt gtt gcc atg gtg 2611 Asn Gly Asn He Wing Leu Wing Trp He Tyr Asn Gly Val Wing Met Val 825 830 835 ctt gca gtg tet ggc ttg ctg cat cca atg gct gcg acc gtg gct atg 2659 Leu Wing Val Ser Gly Leu Leu His Pro Met Wing Wing Thr Val Wing Met 840 845 850 ctg gcg tet tcg ctg ctt att gaa tgg cgc tcg ggc agg gcg cgc aag 2707 Leu Wing Being Ser Leu Leu He Glu Trp Arg Ser Gly Arg Wing Arg Lys 855 860 865 tac taaccageaa ttcccaagcc caa 2733 Tyr 870 <; 210 > 578 < 211 > 870 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 578 Val Asp Lys Ala Val Asn Thr Ala He Ser Asp Ala Lys Thr Ala Ala 1 5 10 15 Leu Lys Ala Gly Val Gly Leu Asn Arg Ala Thr Ala Ser Glu Glu Glu 20 25 30 Glu Asp Leu Ser Ser Ser He Lys Val Ser Leu Ala Phe Glu Leu Glu 35 40 45 Gly Leu Ser Asn Ala Pro Ser Leu Met Val Val Glu Lys Ala Leu Glu 50 55 60 Lys He Pro Gly Val Ser Wing Asp Leu He Tyr Pro Ser Gln Thr Wing 65 70 75 80 Trp He Thr Ala Thr Asp Arg Val His Pro Glu Thr Leu He Glu Val 85 90 95 Phe Glu Gln Phe Gly He Lys Wing His Leu Ser Asn Ser Ser Leu Leu 100 105 110 Arg Arg His Gln Gln Leu Ser Wing Glu Val Asn Arg Glu Ala Arg Leu 115 120 125 Asp Arg Tyr Arg Ser Arg Met Asp Ala Lys Arg He Ser Pro Arg Val 130 135 140 Arg Arg His Asn Arg Gln Glu Met Val His Wing Val Arg Wing Arg Glu 145 150 155 160 Ser Gly Trp He Lys Arg Arg Asn His Thr Thr Ser Gln His Glu Asp 165 170 175 Pro Met Ser Gly Asp Val Leu Phe Thr Ala Arg Ala Leu He Thr Pro 180 185 190 Lys Arg Leu Trp Val Ser Leu Pro Phe Ala Leu He Val Leu Ala Leu 195 200 205 Leu Asn Pro Ser Trp Gln Phe Asp Tyr Trp Gln Trp Leu Ser Wing 5 Ser 210 215 220 Val Leu Ala He Pro Val Val Val Trp Gly Ala Trp Pro Phe His Arg 225 230 235 240 Wing Wing Wing Gly Gly He Arg Arg Gly He Wing Wing Leu Asp Wing Thr 245 250 255 Ser Ser Wing Wing Wing Wing Wing Tyr Wing Trp Ser Wing Wing Met Leu 260 265 270 Leu Phe Glu Thr Pro Gly Gly Lys Ser Trp Arg Ser Tyr Pro Ser Trp 275 280 285 Phe Wing Phe Asp His Gly Thr Leu Thr Gln Asn Glu He Tyr Phe Asp 290 295 300 Wing 10 Val Cys Gly He Thr Val Leu Leu Leu Ala Gly Arg Leu Leu Thr 305 310 315 320 Arg Arg Arg Ser Gln Ser Ser Leu Leu Ala Glu Leu Gly Arg Leu Gln 325 330 335 He Asp Pro Gln Arg He Val Thr Val Val Arg Lys His Arg Le u Lys • 340 345 350 Arg Val Val Gln Glu Leu Asn He Pro Val Gln Glu Val Arg Val Asn 355 360 365 Asp Asp Val Lys Val Pro Pro Asn Thr Thr He Pro Val Asp Gly Thr 370 375 380 Val He Gly Gly Gly Ser Arg He Wing Wing He He Met Met Gly Gln 385 390 395 400 15 Asp Gln Arg Asp Val Lys Val Asn Asp Lys Val Phe Wing Gly Ser Leu 405 410 415 Asn Leu Glu Ser Glu He Lys Val Arg Val He Arg Thr Gly His Arg 420 425 430 Thr Arg He Wing Wing Val His Arg Trp Val Lys Glu Wing Thr Leu Lys 435 440 445 Glu Asn Arg His Asn Arg Wing Wing He Arg Wing Wing Asn Leu Val 450 455 460 Pro He Thr Phe Thr Leu Wing Val Val Asp Phe Cys Leu Trp Wing Leu • 465 470 475 480 He Ser Gly Asn He Asn Wing Wing Phe Thr Thr Thr Leu Wing Val Leu 485 490 495 20 Wing Cys Val Wing Pro Val Wing Leu Wing Leu Wing Pro Wing Leu Wing Thr 500 505 510 Arg Asn Ser He Glu Wing Wing Wing Arg His Gly He Leu Val Arg Ser 515 520 525 Gly Glu He Phe Arg Val Leu Asp Asp Val Asp Thr Wing Val Phe Asn 530 535 540 Arg Val Gly Thr Leu Thr Asp Gly Glu M et Thr Val Glu Thr Val Thr 545 550 555 560 Wing Asp Lys Gly Glu Asp Pro Glu Leu Val Leu Arg Val Wing Gly Wing 565 570 575 Leu Wing Met Glu Ser His His Wing He Ser Lys Wing Leu Val Lys Wing 580 585 590 25 Ser Arg Glu Wing Arg Asp Thr Gly Wing Gly Gly Glu Asp Val Pro His Í i.:! ,, *, M ¡í- .í, .j? t_. ^^^ yfl 595 600 605 Trp He Glu Val Gly Asn Val Glu He Thr Glu Wing Gly Ser Phe Gln 610 615 620 Wing Thr He Glu Leu Pro Leu He Lys Pro Ser Gly Glu Lys He Met 625 630 635 640 Arg Thr Thr Glu Wing Leu Leu Trp Arg Pro Arg Ser Met Thr Glu Val 645 650 655 Arg Glu His Leu Ser Pro Arg Leu Val Wing Wing Wing Thr Ser Gly Gly 660 665 670 Wing Pro Leu He Val Arg Trp Lys Gly Lys Asp Arg Gly Val He Thr 675 680 685 Leu Ser Asp His Val Arg Ser Asp Ser Ser Asp Wing He Wing He Wing 690 695 700 Glu Glu Gln Gly He Glu Thr Met Met Leu Ser Arg Asp Thr Tyr Pro 705 710 715 720 Val Wing Arg Arg Tyr Wing Asp Ser Leu Gly He Thr His Val Leu Wing 725 730 735 Gly He Wing Pro Gly Lys Lys Wing Gln Val Val Arg Wing Val His Thr 740 745 750 Arg Gly Ser Thr Val Wing Met He Gly Asp Glu Ser Val Met Asp Cys 755 760 765 10 Leu Lys Val Wing Asp Val Gly Val Leu Met Gly Val Asp Arg Pro Ser 770 775 780 Asp Leu Arg Asp Asp Ser Asp Asp Pro Wing Wing Asp Val Val Val Met • 785 790 795 800 Arg Glu Glu Val Met Ser Val Pro Thr Le u Phe Lys Leu Wing Arg Arg 805 810 815 Tyr Wing Lys Leu Val Asn Gly Asn He Wing Leu Wing Trp He Tyr Asn 820 825 830 Gly Val Wing Met Val Leu Wing Val Ser Gly Leu Leu His Pro Met Wing 835 840 845 Wing Thr Val Ala Met Leu Ala Be Ser Leu Leu He Glu Trp Arg Ser 850 855 860 15 Gly Arg Ala Arg Lys Tyr 865 870 < 210 > 579 < 211 > 1925 < 212 > DNA < 213 > Corynebacterium glutamicum • < 220 > < 221 > CDS < 222 > (1) .. (1902) 20 < 223 > RXN01338 < 400 > 579 aaa act tat acc cca aat ccc tgg atg tta ttc ate cgc tca ttt gat 48 Lys Thr Tyr Thr Pro Asn Pro Trp Met Leu Phe He Arg Ser Phe Asp 1 5 10 15 ggc ate ate act gtc gca gcc ctt gtt gcc ate gca ata cat etc att 96 Gly He He Thr Val Wing Wing Leu Val Wing He Wing He His Leu He 20 25 30 tta tgg ctg gct cta gat gat gat ggc ctt gct aaa aac tgg ect tta 144 Leu Trp Leu Ala Leu Asp Leu Asp Gly Leu Ala Lys Asn Trp Pro Leu 35 40 45 25 ata gcc ate gtt ate gta ggt ggc att ccg ttg atg tgg gat gtg ctg 192 He Wing He Val He Val Gly He Pro Leu Met Trp Asp Val Leu 50 55 60 aaa tca gcc att aaa act cgc ggt ggc gcg gat act tta gca gca gtc 240 Lys Ser Wing He Lys Thr Arg Gly Gly Wing Asp Thr Leu Wing Wing Val 65 70 75 80 tcc ate att act tet gtg ttg tta ggg gag tgg ttg gtt gcc gcg ate 288 Be He He Thr Ser Val Leu Leu Gly Glu Trp Leu Val Wing Ala He 85 90 95 ate gtg etc atg etc tet ggt ggt gaa gcg cta gaa gag gca gca tca 336 • He Val Leu Met Leu Ser Gly Gly Glu Ala Leu Glu Glu Ala Ala Ser 100 105 110 cgg cga gcc agt ggc acc ttg gac gca ctt gcc cgg cgc gca cca agt 384 Arg Arg Wing Being Gly Thr Leu Asp Wing Leu Wing Arg Arg Wing Pro Being 115 120 125 here gct falls cgc ctg tg ggt gca acc att ctt gat gga acc gag gag 432 Thr Wing His Arg Leu Leu Gly Wing Thr He Leu Asp Gly Thr Glu Glu 130 135 140 ate gcc gtg gaa gag ate acg gtt ggt gatta gtg gcg gtg etc ccg 480 He Wing Val Glu Glu He Thr Val Gly Asp Leu Val Wing Val Leu Pro 145 150 155 160 cat gaa ctt tgt ccc gtg gat ggt gaa ate gtg gca ggc cae ggc acc 528 10 His Glu Leu Cys Pro Val Asp Gly Glu He Val Wing Gly His Gly Thr 165 170 175 atg gat gag tet tat etc acg ggt gag ccc tat gtg gtg agt aaa tet 576 Met Asp Glu Ser Tyr Leu Thr Gly Glu Pro Tyr Val Val Ser Lys Ser 180 185 190 aaa ggt tcg caa gca atg tcg ggt gca gtc aat ggt gat act ccg ctg 624 Lys Gly Ser Gln Wing Met Ser Gly Wing Val Asn Gly Asp Thr Pro Leu 195 200 205 acg att gtt gcc here aag ctt gcc cat gat tcc aga tac gcc caa att 672 Thr He Val Wing Thr Lys Leu Wing His Asp Being Arg Tyr Wing Gln He 210 215 220 gtt ggt gta etc cat gaa gca gaa aac aac cgc cca gaa atg cgc 15 agg 720 Val Gly Val Leu His Glu Ala Glu Asn Asn Arg Pro Glu Met Arg Arg 225 230 235 240 atg gct gac cgt ctt ggc gcg tgg tat acg gtg att gca ctt gcc etc 768 Met Wing Asp Arg Leu Gly Wing Trp Tyr Thr Val He Wing Leu Wing Leu 245 250 255 ggt ggt ctt ggc tgg att gtc tcc ggc gac cca gtg agg ttc ttg gct 816 Gly Gly Leu Gly Trp He Val Ser Gly Asp Pro Val Arg Phe Leu Wing 260 265 270 • gtt gtc gtt gtc gcc acc cca tgt cca ttg etc att gca gtg cca gtg 864 Val Val Val Val Ala Thr Pro Cys Pro Leu Leu He Ala Val Pro Val 275 280 285 20 gcg ate ate ggt gcg att tet ctt gcg gct cgt cgg ggc ate ate gtg 912 Wing He He Gly Wing He Wing Leu Wing Wing Arg Arg Gly He He Val 290 295 300 aag aac ect gga atg ctg gaa aac gct tca gga gta aag a gtg atg 960 Lys Asn Pro Gly Met Leu Glu Asn Wing Be Gly Val Lys Thr Val Met 305 310 315 320 ttc gat aag act gga acg etc acc tat ggc agg cca gtg att act gat 1008 Phe Asp Lys Thr Gly Thr Leu Thr Tyr Gly Arg Pro Val He Thr Asp 325 330 335 ate fall act gct ccc gga gtt gag gaa gat here gtc cta gct ttg gct 1056 He His Thr Ala Pro Gly Val Glu Glu Asp Thr Val Leu Ala Leu Wing 340 345 350 gct tca 25 gta gag cgc tac tcc aga falls ccg ttg gcg gcg att cgt 1104 Wing Ser Val Glu Arg Tyr Ser Arg His Pro Leu Ala Asp Ala He Arg 355 360 365 gag ggc gca aaa gcc agg gaa ctt cat ctg ect gat gta gtg gta gaa 1152 Glu Gly Ala Lys Ala Arg Glu Leu His Leu Pro Asp Val Val Glu Val 370 375 380 gaa tcg cgt cca gga cag gga cta acc ggc acg gtg ggc gag falls ctg 1200 Ser Glu Arg Pro Gly Gln Gly Leu Thr Gly Thr Val Gly Glu His Leu 385 390 395 400 gtt cga ata acc aat agg cgc age here cta gaa att gat cca gac age 1248 Val Arg He Thr Asn Arg Arg Ser Thr Leu Glu He Asp Pro Asp Ser 405 410 415 aag aac tac att ccg gtg here agt tcc ggc atg gaa tet gtg gtg ctt 1296 Lys Asn Tyr He Pro Val Thr Ser Ser Gly Met Glu Ser Val Val Leu 420 425 aaa gat gtt gat 430 tat gca cgc att gca etc etc gat cgg gaa cgt ect Asp Asp Lys Val 1344 Tyr Leu Ala Ala Arg Leu Arg Asp He Pro Arg Glu 435 440 445 gca gag agt gcc ttc tet ate gcg ttg falls cc c aag aag falls aaa gtg 1392 Wing Being Wing Being Glu Phe He Wing His Leu Pro Lys Lys His Lys Val 450 455 460 gac aag etc atg att ate tet ggt gat cgc gca tet gag gtt cgt tac 1440 Asp Lys Leu Met He He Ser Gly Asp Arg Ala Ser Glu Val Arg Tyr 465 470 475 480 ctt gcg gac aag gtt ggc att gat gag gta falls gca gag gcc tca ccg 1488 Leu Ala Asp Lys Val Gly He Asp Glu Val His Ala Glu Ala Ser Pro 485 490 495 gaa gac aag ctg aac att gtt aat cgg cat aat gag falls ggc gcc acc 1536 Glu Asp Lys Leu Asn He Val Asn Arg His Asn Glu His Gly Ala Thr 500 505 510 atg ttc tta ggt gat gga ate aac gat gcg cca gcc atg gcc gtt gcc 1584 Met Phe Leu Gly Asp Gly He Asn Asp Ala Pro Ala Met Ala Ala Ala 515 520 525 acc gtt gtc gtc gcg atg gga gc gc gacc tcc gat gtc acg tcc gaa gca 1632 Thr Val Gly Val Wing Wing Gly Ala Asp Ser Asp Val Thr Ser Glu Wing 530 535 540 gca gat gt gt gtg att ttg gat tet tcc ctg gaa cgt etc gac gat ctg 1680 Wing Asp Wing Val He Leu Asp Ser Ser Leu Glu Arg Leu Asp Asp Leu 545 550 555 560 etc falls atle agt gca cgg atg cgt cga ata gcg ttg caa tet gcg ggc 1728 Leu His He Being Wing Arg Met Arg Arg I have Ala Leu Gln Be Wing Gly 565 570 575 ggt ggc atg gcg ttg agt gtc ata gga atg ate etc gcg gta ttt gga 1776 Gly Gly Met Ala Leu Ser Val He Gly Met He Leu Ala Val Phe Gly 580 585 590 ttc ttg acg cca ctg atg ggt gcg ate ttc caa gag gtc att gac gtg 1824 Phe Leu Thr Pro Leu Met Gly Wing He Phe Gln Glu Val He Asp Val 595 600 605 ctg gct ate etc aat tcc gct cgg gtc gca ctg cca cgc gga gcg att 1872 Leu Ala He Leu Asn Be Wing Arg Val Wing Leu Pro Arg Gly Wing He 610 615 620 agt gat ttt gat acg caa gaa aaa gtt tet tagcagggta acctaaatgt 1922 Ser Asp Phe Asp Thr Gln Glu Lys Val Ser 625 630 cgt 1925 < 210 > 580 < 211 > 634 *** - '- < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 580 Lys Thr Tyr Thr Pro Asn Pro Trp Met Leu Phe He Arg Ser Phe Asp 1 5 10 15 Gly He He Thr Val Wing Wing Leu Val Wing He Wing He His Leu He 20 25 30 Leu Trp Leu Wing Leu Asp Leu Asp Gly Leu Ala Lys Asn Trp Pro Leu • 35 40 45 He Wing He Val He Val Gly He Pro Leu Met Trp Asp Val Leu 50 55 60 Lys Ser Wing He Lys Thr Arg Gly Gly Wing Asp Thr Leu Wing Wing Val 65 70 75 80 Ser He He Ser Ser Val Leu Leu Gly Glu Trp Leu Val Wing Wing He 85 90 95 He Val Leu Met Leu Ser Gly Gly Glu Ala Leu Glu Glu Wing Ala Ser 100 105 110 Arg Arg Ala Ser Gly Thr Leu Asp Ala Leu Ala Arg Arg Ala Pro Ser 115 120 125 Thr Ala His Arg Leu Leu Gly Ala Thr He Leu Asp Gly Thr Glu Glu 10 130 135 140 He Wing Val Glu Glu He Thr Val Gly Asp Leu Val Wing Val Leu Pro 145 150 155 160 • His Glu Leu Cys Pro Val Asp Gly Glu He Val Wing Gly His Gly Thr 165 170 175 Met Asp Glu Ser Tyr Leu Thr Gly Glu Pro Tyr Val Val Ser Lys Ser 180 185 190 Lys Gly Ser Gln Wing Met Ser Gly Wing Val Asn Gly Asp Thr Pro Leu 195 200 205 Thr He Val Wing Thr Lys Leu Wing His Asp Ser Arg Tyr Wing Gln He 210 215 220 Val Gly Val Leu His Glu Wing Glu Asn 15 Asn Arg Pro Glu Met Arg Arg 225 230 235 240 Met Wing Asp Arg Leu Gly Wing Trp Tyr Thr Val He Wing Leu Wing Leu 245 250 255 Gly Gly Leu Gly Trp He Val Ser Gly Asp Pro Val Arg Phe Leu Wing 260 265 270 Val Val Val Val Wing Thr Pro Cys Pro Leu Leu He Wing Val Pro Val 275 280 285 Wing He He Gly Wing He Ser Leu Wing Wing Arg Arg Gly He He Val • 290 295 300 Lys Asn Pro Gly Met Leu Glu Asn Wing Ser Gly Val Lys Thr Val Met 305 310 315 320 Phe Asp Lys Thr Gly Thr Leu Thr Tyr 20 Gly Arg Pro Val He Thr Asp 325 330 335 He His Thr Ala Pro Gly Val Glu Glu Asp Thr Val Leu Ala Leu Wing 340 345 350 Wing Ser Val Glu Arg Tyr Ser Arg His Pro Leu Wing Asp Wing He Arg 355 360 365 Glu Gly Wing Lys Wing Arg Glu Leu His Leu Pro Asp Val Val Glu Val 370 375 380 Ser Glu Arg Pro Gly Gln Gly Leu Thr Gly Thr Val Gly Glu His Leu 385 390 395 400 Val Arg He Thr Asn Arg Arg Ser Thr Leu Glu He Asp Pro Asp Ser 405 410 415 Lys Asn Tyr He Pro Val Thr Ser Ser Gly Met Glu Ser Val Val Leu 25 420 425 430 Val Asp Asp Lys Tyr Ala Ala Leu He Arg Leu Arg Asp Glu Pro Arg 435 440 445 Wing Ser Wing Ser Glu Phe He Wing His Leu Pro Lys Lys His Lys Val 450 455 460 Asp Lys Leu Met He He Ser Gly Asp Arg Ala Ser Glu Val Arg Tyr 465 470 475 480 Leu Wing Asp Lys Val Gly He Asp Glu Val His Wing Glu Ala Pro Pro 485 490 495 • Glu Asp Lys Leu Asn He Val Asn Arg His Asn Glu His Gly Ala Thr 500 505 510 Met Phe Leu Gly Asp Gly He Asn Asp Ala Pro Ala Met Ala Ala Ala 515 520 525 Thr Val Gly Val Ala Met Gly Ala Asp Ser Asp Val Thr Ser Glu Ala 530 535 540 Ala Asp Ala Val Le Le Asp Ser Ser Leu Glu Arg Leu Asp Asp Leu 545 550 555 560 Leu His He Be Wing Arg Met Arg Arg He Wing Leu Gln Ser Wing Gly 565 570 575 Gly Gly Met Wing Leu Ser Val He Gly Met He Leu Wing Val Phe Gly 580 585 590 10 Phe Leu Thr Pro Leu Met Gly Wing He Phe Gln Glu Val He Asp Val 595 600 605 Leu Wing He Leu Asn Be Wing Arg Val Wing Leu Pro Arg Gly Wing He 610 615 620 Ser Asp Phe Asp Thr Gln Glu Lys Val Ser 625 630 < 210 > 581 < 211 > 1917 < 212 > DNA < 213 > Corynebacterium glutamicum 15 < 220 > < 221 > CDS < 222 > (101) .. (1894) < 223 > RXN00980 < 400 > 581 agagagaaag < ? gag¡aaatta tgaaaacgtg ga; agacctgg ggggtcgtcg < gagetteagg 60 cctcttgatt; attttgtctgt ggttgagttt: att: gagcccg atg ctg gca gat gca 115 • Met Leu Ala Asp Ala 1 5 ttc atg ate gcg gct gca att gtt gca ggt tgg ccg ate gcg cag tet 163 Phe Met He Wing Wing Wing He Val Wing Gly Trp Pro Wing Wing Gln Ser 20 10 15 20 gca tat caa gca ctt cgc att cga atg gtg tcg att gac tta ctg gtc 211 Ala Tyr Gln Ala Leu Arg He Arg Met Val Ser He Asp Leu Leu Val 25 30 35 gtt gtg gct gcc gtt ggt gcc atg ttc ate aac aac tat tgg gag tet 259 Val Val Ala Ala Val Gly Ala Met Phe He Asn Asn Tyr Trp Glu Ser 40 45 50 gcg gcg gtg acg ttc etc ttt gcc ctt ggc aag gca ctg gaa cgc gcg 307 Wing Wing Thr Phe Leu Phe Wing Leu Gly Lys Wing Leu Glu Arg Wing 55 60 65 here at a ccc aga cga aaa gca cta tcg gat ctg gtg gat gca gct 355 Thr Met Asn Arg 25 Thr Arg Lys Ala Leu Ser Asp Leu Val Asp Ala Ala Y ? 70 75 80 85 cca gaa act gca here agg etc aac gcg gat gac tca here gag gta gtt 403 Pro Glu Thr Wing Thr Arg Leu Asn Wing Asp Asp Ser Thr Glu Val Val 90 95 100 gag ctg tgg gag ctt gag ccc ggt gac ate gtc ttg gta cgc aat ggc 451 Glu Leu Trp Glu Leu Glu Pro Gly Asp He Val Leu Val Arg Asn Gly 105 110 115 gaa caa att ccc gtc gat gga aac gtg att gcg ggt gtc ggt gga att 499 Glu Gln He Pro Val Asp Gly Asn Val He Wing Gly Val Gly Gly He • 120 125 130 gat gaa tcc aac ate acg ggt gaa tca atg ccg gct gaa aag ggt caa 547 Asp Glu Ser Asn He Thr Gly Glu Ser Met Pro Wing Glu Lys Gly Gln 135 140 145 ggc tet gat gtg tat gca gga acc tgg ctg cga tet ggt gtt ttg aga 595 Gly Ser Asp Val Tyr Wing Gly Thr Trp Leu Arg Ser Gly Val Leu Arg 150 155 160 165 gtc gag gca here gga att ggt tca gac tca act ttg gca aaa ate att 643 Val Glu Ala Thr Gly He Gly Ser Asp Ser Thr Leu Ala Lys He He 170 175 180 falls cgc gtt gaa gac gcc cag gat gac aaa gcc cgc here caa here ttc 691 His Arg Val Glu Asp Ala Gln Asp Asp Lys Ala Arg Thr Gln Thr Phe 10 185 190 195 tta gag aaa ttc tet aag tgg tac acc ccg ggc gtc atg ate gcc gcc 739 Leu Glu Lys Phe Be Lys Trp Tyr Thr Pro Gly Val Met He Wing Wing 200 205 210 gca gtg gtg gga ctt ate acc tgg gac gta gaa cta gca ctg acg etc 787 Wing Val Val Gly Leu He Thr Trp Asp Val Glu Leu Ala Leu Thr Leu 215 220 225 tta gtg ate ggc tgc ccc ggc gcg ttg gtt ate tcc ate ccg gtg tcc 835 Leu Val He Gly Cys Pro Gly Ala Leu Val He Ser He Pro Val Ser 230 235 240 245 ate gtc gca ggc ate ggc cgt gct gc a cgc gat ggc gtg ctg ate aag 883 He Val Wing Gly He Gly Arg Wing Wing Arg Asp Gly Val Leu He Lys 15 250 255 260 ggt gga gaa tac cta gaa acc gcc gcg aaa gtc gac gtc gtt gtc gtg 931 Gly Gly Glu Tyr Leu Glu Thr Wing Wing Lys Val Asp Val Val Val Val 265 270 275 gac aaa act gga acg ctg acc acc ggc cgc cca gaa etc here gac gta 979 Asp Lys Thr Gly Thr Leu Thr Thr Gly Arg Pro Glu Leu Thr Asp Val 280 285 290 gaa gtc ate gag ccc gcc tac age cag ggc gag gtg ctg gag etc gcc 1027 • Glu Val He Glu Pro Wing Tyr Ser Gln Gly Glu Val Leu Glu Leu Wing 295 300 305 gcg cgc gcc gag acg gct tca gaa cat ccg ctt gcc gac gcc ate ate 1075 Ala Arg Ala Glu Thr Ala Ser Glu His Pro Leu Ala Asp Ala He He 20 310 315 320 325 cgt ggt gcc cag gat cgg ggg ctg tcc here here ttg gtg gaa gca gct 1123 Arg Gly Wing Gln Asp Arg Gly Leu Ser Thr Thr Leu Val Glu Ala Wing 330 335 340 gaa aac ate acc ggc cga ggc att ate gca aat gtt gat gga cag gca 1171 Glu Asn He Thr Gly Arg Gly He He Wing Asn Val Asp Gly Gln Wing 345 350 355 gtt gtt gt gga tet gct gag tta ctt gat cat gaa cca gac tcg acc 1219 Val Ala Val Gly Ser Ala Glu Leu Leu Asp His Glu Pro Asp Ser Thr 360 365 370 agg ate ctg gag cta aat gcc gaa gga aag acc gcg atg ttt gtc gga 1267 Arg He Leu Glu Leu Asn Wing Glu Gly Lys Thr Wing Met Phe Val Gly 25 lAtiá it.i * -.? .¿s-,. ^ .. _...., .. * 4t t.?.i,i?¿ 375 380 385 gtg aac gga falls gcc att gga ate gtg gcc gtc gcc gac gcc gtt cgt 1315 Val Asn Gly His Wing He Gly He Val Wing Val Wing Asp Wing Val Arg 390 395 400 405 tca gat tet gcc tca gca ate gaa tcg ctg cat aag gcg ggc att caa 1363 Being Asp Being Wing Being Wing He Glu Being Leu His Lys Wing Gly He Gln 410 415 420 gtt gtc atg gcg act ggc gac gct fall cgc gtt gca caa aac gtg gcc 1411 Val Val Met Wing Thr Gly Asp Wing His Arg Val Wing Gln Asn Val Wing • 425 430 435 tcc aag ctg gga gtg gat gaa gtc tac tca gag cta etc ect gaa cag 1459 Ser Lys Leu Gly Val Asp Glu Val Tyr Ser Glu Leu Leu Pro Glu Gln 440 445 450 aaa tta gaa ctg gtg cgt gat ctg caa gct gcc ggc aaa acg gtc gcg 1507 Lys Leu Glu Leu Val Arg Asp Leu Gln Wing Wing Gly Lys Thr Val Wing 455 460 465 atg gtg ggt gac gga gtc aac gac acc cca gca ttg gca gct gct gat 1555 Met Val Gly Asp Gly Val Asn Asp Thr Pro Wing Leu Wing Wing Asp 470 475 480 485 ate gga gta gcg atg ggc gtg gca ggt tcc ect gca gcc att gaa acc 1603 10 He Gly Val Wing Met Gly Val Wing Gly Ser Pro Ala Wing He Glu Thr 490 495 500 gct gat gca gt cat etc atg gcg gat cgt etc cca cgg cg gca cat gca 1651 Wing Asp He Ala Leu Met Wing Asp Arg Leu Pro Arg Leu Wing His Wing # 505 510 515 gtg acc ttg gca aaa cgc acc gta aga acc atg cgc ate aat att ctg 1699 Val Thr Leu Wing Lys Arg Thr Val Arg Thr Met Arg He Asn He Leu 520 525 530 att gcg ttg gct acc gtg atg gtg tta cta gct ggc gtc cta ttt ggc 1747 I have Ala Leu Ala Thr Val Val Met Leu Leu Ala Gly Val Leu Phe Gly 535 540 545 gga gtt acc atg tcg gtt ggc atg etc gtt falls gaa gca age gtg ctg 1795 15 Gly Val Thr Met Ser Val Gly Met Leu Val His Glu Ala Ser Val Leu 550 555 560 565 ctt gtt ate age ate gcc atg ctg ttg ctg cgt cca here ctt aaa gaa 1843 Leu Val He Ser He Wing Met Leu Leu Leu Arg Pro Thr Leu Lys Glu 570 575 580 gat gct gcg caa gca agt gat att aaa cgc tcg gaa ata caa cag ate 1891 Asp Ala Ala Gln Ala Be Asp He Lys Arg Ser Glu He Gln Gln He 585 590 595 gca taaccaat; gg ctgggtactg at -g 1917 • To 20 < 210 > 582 < 211 > 598 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 582 Met Leu Ala Asp Ala Phe Met He Ala Ala Ala He Val Val Gly Trp 1 5 10 15 Pro He Ala Gln Ser Ala Tyr Gln Ala Leu Arg He Arg Met Val Ser 20 25 30 He Asp Leu Leu Val Val Val Ala Ala Val Gly Ala Met Phe He Asn 35 40 45 25 Asn Tyr Trp Glu Be Wing Wing Val Thr Phe Leu Phe Ala Leu Gly Lys ^^^^^^ J 50 55 60 Wing Leu Glu Arg Wing Thr Met Asn Arg Thr Arg Lys Wing Leu As Asp 65 70 75 80 Leu Val Asp Wing Wing Pro Glu Thr Wing Thr Arg Leu Asn Wing Asp Asp 85 90 95 Ser Thr Glu Val Val Glu Leu Trp Glu Leu Glu Pro Gly Asp He Val 100 105 110 Leu Val Arg Asn Gly Glu Gln He Pro Val Asp Gly Asn Val He Wing 115 120 125 • Gly Val Gly Gly He Asp Glu Ser Asn He Thr Gly Glu Ser Met Pro 130 135 140 Wing Glu Lys Gly Gln Gly Ser Asp Val Tyr Wing Gly Thr Trp Leu Arg 145 150 155 160 Ser Gly Val Leu Arg Val Glu Wing Thr Gly He Gly Ser Asp Ser Thr 165 170 175 Leu Ala Lys He He His Arg Val Glu Asp Ala Gln Asp Asp Lys Wing 180 185 190 Arg Thr Gln Thr Phe Leu Glu Lys Phe Ser Lys Trp Tyr Thr Pro Gly 195 200 205 Val Met He Ala Ala Ala Val Val Gly Leu He Thr Trp Asp Val Glu 210 215 220 10 Leu Ala Leu Thr Leu Leu Val He Gly Cys Pro Gly Ala Leu Val He 225 230 235 240 Ser He Pro Val Ser He Val Wing Gly He Gly Arg Ala Wing Arg Asp • 245 250 255 Gly Val Leu He Lys Gly Gly Glu Tyr Leu Glu T hr Ala Ala Lys Val 260 265 270 Asp Val Val Val Asp Lys Thr Gly Thr Leu Thr Thr Gly Arg Pro 275 280 285 Glu Leu Thr Asp Val Glu Val He Glu Pro Wing Tyr Ser Gln Gly Glu 290 295 300 Val Leu Glu Leu Wing Wing Arg Wing Glu Thr Wing Ser Glu His Pro Leu 305 310 315 320 15 Wing Asp Wing He He Arg Gly Wing Gln Asp Arg Gly Leu Ser Thr Thr 325 330 335 Leu Val Glu Wing Wing Glu Asn He Thr Gly Arg Gly He He Wing Asn 340 345 350 Val Asp Gly Gln Wing Val Wing Val Gly Ser Wing Glu Leu Leu Asp His 355 360 365 Glu Pro Asp Ser Thr Arg He Leu Glu Leu Asn Wing Glu Gly Lys Thr 370 375 380 Wing Met Phe Val Gly Val Asn Gly His Wing He Gly He Val Val Wing 385 390 395 400 Wing Asp Wing Val Arg Ser Asp Wing Wing Wing He Glu Ser Leu His 405 410 415 20 Lys Wing Gly He Gln Val Val Met Wing Thr Gly Asp Wing His Arg Val 420 425 430 Wing Gln Asn Val Wing Ser Lys Leu Gly Val Asp Glu Val Tyr Ser Glu 435 440 445 Leu Leu Pro Glu Gln Lys Leu Glu Leu Val Arg Asp Leu Gln Wing Wing 450 455 460 Gly Lys Thr Val Wing Met Val Gly Asp Gly Val Asn Asp Thr Pro Wing 465 470 475 480 Leu Wing Wing Wing Asp He Gly Val Wing Wing Gly Val Wing Gly Ser Pro 485 490 495 Wing Wing He Glu Thr Wing Wing Asp He Wing Leu Met Wing Asp Arg Leu Pro 500 505 510 25 you -i ,, 1, i .i ,, __;. _. _,. __,: .t jtr *, l, kn Arg Leu Wing His Wing Val Thr Leu Wing Lys Arg Thr Val Arg Thr Met 515 520 525 Arg He Asn He Leu He Wing Leu Wing Thr Val Met Val Leu Leu Wing 530 535 540 Gly Val Leu Phe Gly Gly Val Thr Met Ser Val Gly Met Leu Val His 545 550 555 560 Glu Ala Ser Val Leu Leu Val He Ser He Ala Met Leu Leu Leu Arg 565 570 575 Pro Thr Leu Lys Glu Asp Ala Ala Gln Ala Ser Asp He Lys Arg Ser 580 585 590 Glu He Gln Gln He Wing 595 <; 210 > 583 < 211 > 1296 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1273) 10 < 223 > RXN00099 < 400 > 583 • ctctggtgaa igaggatgtltg aictcgggaga ttcttccact gatlcactga 1btaatgtggta 60 ccgcgcaaat, aggt; agtect ttgettatatg ggtcaggggc gtg aag aat ect cgc 115 Val Lys Asn Pro Arg 1 5 etc ata gca ctg gcc gct ate ate ctg acc tcg ttc aat ctg cga here 163 Leu He Ala Leu Wing Wing He He Leu Thr Ser Phe Asn Leu Arg Thr 10 15 20 gct att act gct tta gct ccg ctg gtt tet gag att cgg gat gat tta 211 Wing He Thr Wing Leu Wing Pro Leu Val Ser Glu He Arg Asp Asp Leu 15 25 30 35 ggg gtt agt gct tet ctt att ggt gtg ttg ggc atg ate ccg act gct 259 Gly Val Ser Wing Being Leu He Gly Val Leu Gly Met He Pro Thr Wing 40 45 50 atg tcc gcg gcg gat gcg ttt gcg ctt ccg tcg tcg aag agg aag ttc 307 Met Phe Wing Asp Wing Wing Phe Wing Leu Pro Ser Leu Lys Arg Lys Phe 55 60 65 act act tcc caa ctg ttg atg ttt gcc atg ctg ttg act gct gcc ggt 355 • Thr Thr Ser Gln Leu Leu Met Phe Wing Met Leu Leu Thr Wing Wing Gly 70 75 80 85 cag att att cgt gtc gct gct ect gct tcg ctg ttg atg gtc ggt act 403 Gln He He Arg Val Ala Gly Pro Ala Ser Leu Leu Met Val Gly Thr 20 90 95 100 gtg ttc gcg atg ttt gcg ate gga gtt acc aat gtg ttg ctt ccg att 451 Val Phe Wing Met Phe Wing He Gly Val Thr Asn Val Leu Leu Pro He 105 110 115 gtt gtt agg gag tat ttt ccg cgt falls gtc ggt gga atg tcg here act 499 Wing Val Arg Glu Tyr Phe Pro Arg His Val Gly Gly Met Ser Thr Thr 120 125 130 tat ctg gtg gtg gtg gtg cag att gtt cag gt ctt gct ccg gt 547 Tyr Leu Val Be Phe Gln He Val Gln Ala Leu Wing Pro Thr Leu Wing 135 140 145 gtg ccg att tet cag tgg gct here cat gtg ggg ttg acc ggt tgg agg 595 Val Pro He Ser Gln Trp Ala Thr His Val Gly Leu Thr Gly Trp Arg 25 150 155 160 165 gtg tcg etc ggt tcg tgg gcg ctg ctg ggg ttg gtt gcg gcg att tcg 643 Val Ser Leu Gly Ser Trp Ala Leu Leu Gly Leu Val Ala Ala He Ser 170 175 180 tgg att ccg ctg ttg agt ttg cag ggt gcc agg gtt gtt gcg gcg ccg 691 Trp He Pro Leu Leu Ser Leu Gln Gly Wing Arg Val Val Wing Wing Pro 185 190 195 tcg aag gtt tet ctt ect gtg tgg aag tet tcg gtt ggt ggg ggg etc 739 Ser Lys Val Ser Leu Pro Val Trp Lys Ser Ser Val Gly Val Gly Leu 200 205 210 ggg ttg atg ttt ggg ttt act tcg ttt gcg acg tat ate etc atg ggt 787 Gly Leu Met Phe Gly Phe Thr Ser Phe Wing Thr Tyr He Leu Met Gly 215 220 225 ttt atg ccg cag atg gta ggt gat ect cag etc ggt gcg gtg ttg tta 835 Phe Met Pro Gln Met Val Gly Asp Pro Gln Leu Gly Ala Val Leu Leu 230 235 240 245 ggc tgg tgg tca att ttg gga ttg ccg ctg aac att ctg gga ccg tgg 883 Gly Trp Trp Ser He Leu Gly Leu Pro Leu Asn He Leu Gly Pro Trp 250 255 260 ttg gtg acg cgt ttc act aac tgc tcc atc gtt gtt ate gcc agt 931 Leu Val Thr Arg Phe Thr Asn Cys P he Pro Met Val Val He Wing Wing Ser 265 270 275 gtc atg ttt etc ate ggt aat ggt ggg ttt tgt ttg gct ccg gat gtt 979 Val Met Phe Leu He Gly Asn Gly Gly Phe Cys Leu Ala Pro Asp Val 280 285 290 gcg ccg tgg ttg tgg gcg tg tg tg tg tg tg tg tg tg tg tg tg tg tg tg tg tg tg tg tg tg tg tg tgg tg tgg tg tgg tgg tgg tgg tgg tgg tggg Pro Met Ala Leu Thr Leu He Asn He Arg Ala Glu Thr Ser Ala Gly 310 315 320 325 gct tet gcg ttg agt tcc ttc ggg cag ggt ttg ggt tat acg att gcg 1123 Wing Being Wing Leu Being Ser Phe Gly Gln Gly Leu Gly Tyr Thr He Wing 330 335 340 tgt ttc ggt ccc ttg ttg act ggt ttc att gtc gat gcg here ggc age 1171 Cys Phe Gly Pro Leu Leu Thr Gly Phe He Val Asp Wing Thr Gly Ser 345 350 355 ttc cga here ate ttt gtg ctt ttt gcg gtt gca gca here etc ttc gtt att 1219 Phe Arg Thr He Phe Val Leu Phe Ala Val Ala Thr Leu Phe Val He 360 365 370 aga ggc ggt tac ttt gcg here agg cag gtt tac gtc gaa aag ctt tta 1267 Arg Gly Gly Tyr Phe Wing Thr Arg Gln Val Tyr Val Glu Lys Leu Leu 375 380 385 aat cgc taggatggcg ctatgccgca aag 1296 Asn Arg 390 < 210 > 584 < 211 > 391 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 584 Val Lys Asn Pro Arg Leu He Ala Ala Ala Ala He He Leu Thr Ser 1 5 10 15 Phe Asn Leu Arg Thr Ala He Thr Ala Leu Ala Pro Leu Val Ser Glu 20 25 30 He Arg Asp Asp Leu Gly Val Be Wing Be Leu He Gly Val Leu Gly 35 40 45 Met He Pro Thr Wing Met Phe Wing Asp Wing Wing Phe Wing Leu Pro Ser 50 55 60 Leu Lys Arg Lys Phe Thr Thr Ser Gln Leu Leu Met Phe Ala Met Leu 65 70 75 80 Leu Thr Ala Ala Gly Gln He He Arg Val Ala Gly Pro Ala Ser Leu 85 90 95 Leu Met Val Gly Thr Val Phe Ala Met Phe Ala He Gly Val Thr Asn • 100 105 110 Val Leu Leu Pro He Wing Val Arg Glu Tyr Phe Pro Arg His Val Gly 115 120 125 Gly Met Ser Thr Thr Tyr Leu Val Ser Phe Gln He Val Gln Ala Leu 130 135 140 Wing Pro Thr Leu Wing Val Pro He Ser Gln Trp Ala Thr His Val Gly 145 150 155 160 Leu Thr Gly Trp Arg Val Ser Leu Gly Ser Trp Ala Leu Leu Gly Leu 165 170 175 Val Ala Ala Be Ser Trp He Pro Leu Leu Ser Leu Gln Gly Ala Arg 180 185 190 Val Val Ala Ala Pro Ser Lys Val Ser Leu Pro Val Trp Lys Ser Ser 10 195 200 205 Val Gly Val Gly Leu Gly Leu Met Phe Gly Phe Thr Ser Phe Ala Thr 210 215 220 • Tyr He Leu Met Gly Phe Met Pro Gln Met Val Gly Asp Pro Gln Leu 225 230 235 240 Gly Wing Val Leu Leu Gly Trp Trp Ser He Leu Gly Leu Pro Leu Asn 245 250 255 He Leu Gly Pro Tr Leu Val Thr Arg Phe Thr Asn Cys Phe Pro Met 260 265 270 Val Val He Wing Ser Val Met Phe Leu He Gly Asn Gly Gly Phe Cys 275 280 285 Leu Wing Pro Asp Val Wing Pro Trp Leu Trp Wing Thr Leu Ser Gly Leu 15 290 295 300 Gly Pro Leu Ala Phe Pro Met Ala Leu Thr Leu He Asn He Arg Ala 305 310 315 320 Glu Thr Be Wing Gly Wing Be Wing Leu Be Ser Phe Gly Gln Gly Leu 325 330 335 Gly Tyr Thr He Wing Cys Phe Gly Pro Leu Leu Thr Gly Phe He Val 340 345 350 Asp Wing Thr Gly Ser Phe Arg Thr He Phe Val Leu Phe Ala Ala Wing • 355 360 365 Thr Leu Phe Val He Arg Gly Gly Tyr Phe Wing Thr Arg Gln Val Tyr 370 375 380 Val Glu Lys Leu Leu Asn Arg 20 385 390 < 210 > 585 < 211 > 387 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (364) < 223 > RXN02662 25 ccaaggtgtc; accctcaccg ttgccatcgc cttcatcatc gtcaatalbeg t? Cgtggacct 60 gctctactgtc < ctggtcaatc cacgtattag gageatetag atg cgc cgt aaa cta 115 Met Arg Arg Lys Leu 1 5 acc acta tta gaa aac aag ccc ggt gca cga ctt ggt ggc ttc cgc 163 Thr Thr Leu Glu Asn Lys Pro Gly Wing Arg Leu Gly Gly Phe Arg 10 15 20 gca ctt gca cca act tca aaa ate gcg ctg gtt ttc ctt etc ctg ate 211 • Ala Leu Ala Pro Thr Ser Lys He Ala Leu Val Phe Leu Leu Leu He 25 30 35 ttc etc etc gcg ate ttt gcc cca ctg att gct aaa tac gat cca ctg 259 Phe Leu Leu Wing He Phe Wing Pro Leu He Wing Lys Tyr Asp Pro Leu 40 45 50 gcc tcc gga act cca gtc cag ect cca age ggt gag falls tgg ttt ggt 307 Wing Ser Gly Thr Pro Val Gln Pro Pro Ser Gly Glu His Trp Phe Gly 55 60 65 acc gac gcc ate ggc cgc gat att ttc tcc cgc gta gcc acg gcg cca 355 Thr Asp Ala He Gly Arg Asp He Phe Ser Arg Val Ala Thr Ala Pro 70 75 80 85 10 gag ect ccc tgatcattgg tcttttcgct acg 387 Glu Pro Pro • < 210 > 586 < 211 > 88 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 586 Met Arg Arg Lys Leu Thr Thr Thr Leu Glu Asn Lys Pro Gly Wing Arg 1 5 10 15 15 Leu Gly Gly Phe Arg Wing Leu Wing Pro Thr Ser Lys He Wing Leu Val 20 25 30 Phe Leu Leu He Phe Leu Leu Wing He Phe Wing Pro Leu He Wing 35 40 45 Lys Tyr Asp Pro Leu Wing Ser Gly Thr Pro Val Gln Pro Pro Ser Gly 50 55 60 Glu His Trp Phe Gly Thr Asp Wing He Gly Arg Asp He Phe Ser Arg 65 70 75 80 Val Ala Thr Ala Pro Glu Pro Pro • 85 < 210 > 587 20 < 211 > 972 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (949) < 223 > RXN02442 < 400 > 587 gcegtgatgt tgttgagcgc gatgtgattg ccgtatgtgc atgtgagatt ccggacgctg 60 agttctgcca ttccttaatg ataacggtta tcattttcaa atg aag ttt ttt act 115 25 Met Lys Phe Phe Thr gac gcc etc ata gtg ect ttt gac gtt tca ttc ate tcc cgc gcc ctg 163 Asp Ala Leu He Val Pro Phe Asp Val Ser Phe He Ser Arg Ala Leu 10 15 20 gtc gcc gga tgc ctg gcc gca att tta tgc tca etc att gga acg tgg 211 Val Wing Gly Cys Leu Wing Wing He Leu Cys Ser Leu He Gly Thr Trp 25 30 35 gtt att ttg cgc agg cta acc ttt tcg gcc gac gct atg tcg cae ggc 259 Val He Leu Arg Arg Leu Thr Phe Phe Gly Asp Wing Met Ser His Gly 40 45 50 ttg etc ccc gga gta gcc acg gca tca cta ttg ggc gga aat etc atg 307 Leu Leu Pro Gly Val Wing Thr Wing Being Leu Leu Gly Gly Asn Leu Met 55 60 65 ttc ggc gca gca ate age gca tta ate atg tca gcc gga gtg gtg tgg 355 Phe Gly Ala Ala Be Ser Ala Leu He Met Be Ala Gly Val Val Trp 70 75 80 85 acc age aga aaa tcc age etc tcc caa gac gtc age att ggc ctg caa 403 Thr Ser Arg Lys Ser Ser Leu Ser Gln Asp Val Ser He Gly Leu Gln 90 95 100 ttt att acc atg ctt tcc etc ggc gtg gtt att gtg tcc falls tcc gat 451 Phe He Thr Met Leu Ser Leu Gly Val Val He Val Ser His Ser Asp 105 110 115 tcc falls gcc gta gac etc acc agt ttc ctt ttt gga gac att ctt ggc 499 Ser His Wing Val Asp Leu Thr Ser Phe Leu Phe Gly Asp He Leu Gly 120 125 130 gtg cga ccc tcg gat ata ttc ate ate gcc att gca here gtg ttg ggt 547 Val Arg Pro Be Asp He Phe He He Wing He Wing Thr Val Leu Gly 135 140 145 gga ttg act att ttt etc ttc falls cga cag ttc act gca etc gct ttc 595 Gly Leu Thr He Phe Leu Phe His Arg Gln Phe Thr Ala Leu Ala Phe 150 155 160 165 gac gag cgt aaa gct falls acc tta gga etc aat ccc cgc ttt gca falls 643 Asp Glu Arg Lys Wing His Thr Leu Gly Leu Asn Pro Arg Phe Wing His 170 175 180 cta etc atg ctg gca ctg ate gca tta gct acg gtg gtg tcg ttt cag 691 Leu Leu Met Leu Ala Leu He Ala Leu Ala Thr Val Val Ser Phe Gln 185 190 195 gtg gtg gga acg ctt tta gtg ttt gga ctt etc att ggt ccg ccc gcc 739 Val Val Gly Thr Leu Leu Val Phe Gly Leu Leu He Gly Pro Pro Wing 200 205 210 acg gct gta ctt tta gtg caa gac aaa gca agt att tca ctg ate atg 787 Thr Wing Wing Leu Leu Val Gln Asp Lys Wing Being He is Leu He Met 215 220 225 ate gtc gcg tcg ctt ctt gga tgc gcg gaa att tac etc ggg ctt tta 835 He Val Ala Ser Leu Leu Gly Cys Ala Glu He Tyr Leu Gly Leu Leu 230 235 240 245 ate age tgg falls gca age act gcc gcg gga gcc act ate act ttg tta 883 He Ser Trp His Wing Ser Thr Wing Wing Gly Wing Thr He Thr Leu Leu 250 255 260 agt gct gcg ata ttt ttt gcc acc tta ttg here aag agt gcc att agt 931 Be Ala Ala He Phe Phe Ala Thr Leu Leu Thr Lys Ser Ala He Ser 265 270 275 agg tta aac ttc acc gcg tgataetc [aa eigacatttt: c aat 972 Arg Leu Asn Phe Thr Ala 280 < 210 > 588 < 211 > 283 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 588 Met Lys Phe Phe Thr Asp Ala Leu He Val Pro Phe Asp Val Ser Phe 1 5 10 15 He Ser Arg Ala Leu Val Ala Gly Cys Leu Ala Ala He Leu Cys Ser 20 25 30 • Leu He Gly Thr Trp Val He Leu Arg Arg Leu Thr Phe Phe Gly Asp 35 40 45 Wing Met Being His Gly Leu Leu Pro Gly Val Wing Thr Wing Being Leu Leu 50 55 60 Gly Gly Asn Leu Met Phe Gly Wing Wing He Ser Wing Leu He Met Ser 65 70 75 80 Wing Gly Val Val Trp Thr Ser Arg Lys Ser Ser Leu Ser Gln Asp Val 85 90 95 Ser He Gly Leu Gln Phe He Thr Met Leu Ser Leu Gly Val Val He 100 105 110 Val Ser His Ser Asp Ser His Wing Val Asp Leu Thr Ser Phe Leu Phe 10 115 120 125 Gly Asp He Leu Gly Val Arg Pro Be Asp He Phe He He Wing He 130 135 140 Wing Thr Val Leu Gly Gly Leu Thr He Phe Leu Phe His Arg Gln Phe 145 150 155 160 Thr Ala Leu Wing Phe Asp Glu Arg Lys Wing His Thr Leu Gly Leu Asn 165 170 175 Pro Arg Phe Wing His Leu Leu Met Leu Wing Leu He Wing Leu Wing Thr 180 185 190 Val Val Being Phe Gln Val Val Gly Thr Leu Leu Val Phe Gly Leu Leu 195 200 205 H e Gly Pro Pro Wing Thr Wing Wing Leu Leu Val Gln Asp Lys Wing Ser 15 210 215 220 I've Been Leu He Met He Val Wing Being Leu Leu Gly Cys Wing Glu He 225 230 235 240 Tyr Leu Gly Leu Leu He Ser Trp His Wing Be Thr Wing Wing Gly Wing 245 250 255 Thr He Thr Leu Leu Be Wing Wing He Phe Phe Wing Thr Leu Leu Thr 260 265 270 Lys Ser Wing Be Arg Leu Asn Phe Thr Wing 275 280 • < 210 > 589 < 211 > 1077 20 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1054! < 223 > RXN02443 < 400 > 589 caagcactgc cgcgggagcc actatcactt tgttaagtgc tgegatattt tttgccacct 60 tattgacaaa gagtgecatt agtaggttaa acttcaccgc gtg ata ctg aaa gac 115 Val He Leu Lys Asp 25 1 5 att ttc aat aat ggg gag etc ttt ggg gct tcc tcc gcg aaa aat ttc 163 He Phe Asn Asn Gly Glu Leu Phe Gly Wing Being Ser Wing Lys Asn Phe 10 15 20 cga aaa cta cta gct gtt cca gcc gtt gcc gcc tca cta gct ttt ggt 211 Arg Lys Leu Leu Ala Val Pro Ala Val Ala Ala Ser Leu Ala Phe Gly 25 30 35 ate acc gcc tgt tcc gct gta gat gac acc ect gac att gtg gtc acc 259 He Thr Ala Cys Ser Wing Val Asp Asp Thr Pro Asp He Val Val Thr 40 45 50 • acc aac ate ctg ggt gat gtt gta age cat ate gtg gga gat tcc gca 307 Thr Asn He Leu Gly Asp Val Val Ser His He Val Gly Asp Ser Wing 55 60 65 gat gtc caa gta etc atg aaa ccc aac gca gat cca cat tcc ttc gga 355 Asp Val Gln Val Leu Met Lys Pro Asn Wing Asp Pro His Ser Phe Gly 70 75 80 85 gtc tca gca caa gac gcc gct gcc atg gaa cat gcc gat etc ate gtg 403 Val Ser Ala Gln Asp Ala Ala Ala Met Glu His Wing Asp Leu He Val 90 95 100 gcc aat gga cta gga ctt gaa gag ggc ctt caa tcc aat gtg gac aat 451 Wing Asn Gly Leu Gly Leu Glu Glu Gly Leu Gln Being Asn Val Asp Asn 10 105 110 115 gcc aaa age caa ggg gtt ccc gtc ttg gaa gtc ggc gaa cae ate gat 499 Ala Lys Ser Gln Gly Val Pro Val Leu Glu Val Gly Glu His He Asp 120 125 130 • gtc att gac tac tcc ccc ggc gtt cca gat ect cae ttt tgg here gac 547 Val He Asp Tyr Ser Pro Gly Val Pro Asp Pro His Phe Trp Thr Asp 135 140 145 ccg gcg cgc atg ate gcc gcc acg gaa gtt ata gaa gct gaa ctg ate 595 Pro Ala Arg Met He Ala Ala Thr Glu Val He Glu Ala Glu Leu He 150 155 160 165 aaa gaa etc gat ect tcc ctg act gaa tcg ate aca caca tca gcc cag 643 Lys Glu Leu Asp Pro Be Leu Thr Glu Be He Thr Gln Be Wing Gln 15 170 175 180 fall tac cgt gag gaa ctt gtt gcc ctt gat gag gaa gtc acc gaa ttg 691 His Tyr Arg Glu Glu Leu Val Wing Leu Asp Glu Glu Val Thr Glu Leu 185 190 195 etc. age ggc gtg gcc cca gaa aac cgc aag ctg gta acc aat falls to 739 Leu Ser Gly Val Wing Pro Glu Asn Arg Lys Leu Val Thr Asn His Asn 200 205 210 gtt ttt gga tac ctg gcc age cgg ttt aac tac acc gtc att gac acc 787 Val Phe Gly Tyr Leu Wing Ser Arg Phe Asn Tyr Thr Val He Asp Thr • 215 220 225 ate ate cca ggt gga age here ttg gcg gcg ect tca gca tet gac etc 835 He He Pro Gly Gly Ser Thr Leu Wing Pro Pro Wing Being Asp Leu 20 230 235 240 245 aat gac ate tcc acc gcc ate gaa gac aac aat gtt ccc gca ate ttc 883 Asn Asp He Ser Thr Wing He Glu Asp Asn Asn Val Pro Wing Wing Phe 250 255 260 acc gat tca age cca cag cgg tta gct gaa gtg ttg gcc age aac 931 Thr Asp Thr Ser Ser Pro Gln Arg Leu Wing Glu Val Leu Wing Ser Asn 265 270 275 gct ggc att gat gtt caa gtg gtg tcc att ttc acg gaa tca etc acc 979 Wing Gly He Asp Val Gln Val Val Ser He Phe Thr Glu Ser Leu Thr 280 285 290 gat gca gat ggt gaa gca ccc acc tac ate age atg caa aaa ate aat 1027 Asp Wing Asp Gly Glu Wing Pro Thr Tyr He Ser Met Gln Lys He Asn 25 295 300 305 gcc gag cgc att gca age act ttg tcc taaacagtcc taaacagtct 1074 Wing Glu Arg He Wing Ser Thr Leu Ser 310 315 taa 1077 < 210 > 590 < 211 > 318 < 212 > PRT < 213 > Corynebacterium glutamicum • < 400 > 590 Val He Leu Lys Asp He Phe Asn Asn Gly Glu Leu Phe Gly Wing Be 1 5 10 15 Be Wing Lys Asn Phe Arg Lys Leu Leu Wing Val Pro Wing Val Wing Wing 20 25 30 Ser Leu Wing Phe Gly He Thr Wing Cys Ser Wing Val Asp Asp Thr Pro 35 40 45 Asp He Val Val Thr Thr Asn He Leu Gly Asp Val Val Ser His He 50 55 60 Val Gly Asp Ser Wing Asp Val Gln Val Leu Met Lys Pro Asn Wing Asp 10 65 70 75 80 Pro His Ser Phe Gly Val Ser Wing Gln Asp Ala Wing Wing Met Glu His 85 90 95 Wing Asp Leu He Val Wing Asn Gly Leu Gly Leu Glu Glu Gly Leu Gln • 100 105 110 Ser Asn Val Asp Asn Wing Lys Ser Gln Gly Val Pro Val Leu Glu Val 115 120 125 Gly Glu His He Asp Val He Asp Tyr Pro Pro Gly Val Pro Asp Pro 130 135 140 His Phe Trp Thr Asp Pro Ala Arg Met He Ala Ala Thr Glu Val He 145 150 155 160 Glu Ala Glu Leu He Lys Glu Leu Asp Pro Ser Leu Thr Glu Ser He 15 165 170 175 Thr Gln Ser Wing Gln His Tyr Arg Glu Glu Leu Val Wing Leu Asp Glu 180 185 190 Glu Val Thr Glu Leu Leu Ser Gly Val Wing Pro Glu Asn Arg Lys Leu 195 200 205 Val Thr Asn His Asn Val Phe Gly Tyr Leu Wing Ser Arg Phe Asn Tyr 210 215 220 Thr Val He Asp Thr He He Pro Gly Gly Ser Thr Leu Wing Ala Pro 225 230 235 240 • Ser Wing Being Asp Leu Asn Asp He Ser Thr Ala He Glu Asp Asn Asn 245 250 255 Val Pro Wing He Phe Thr Asp Thr Ser Ser Pro Gln Arg Leu Wing Glu 20 260 265 270 Val Leu Wing Ser Asn Wing Gly He Asp Val Gln Val Val Ser He Phe 275 280 285 Thr Glu Ser Leu Thr Asp Wing Asp Gly Glu Wing Pro Thr Tyr He Ser 290 295 300 Met Gln Lys He Asn Wing Glu Arg He Wing Ser Thr Leu Ser 305 310 315 < 210 > 591 < 211 > 1323 < 212 > DNA < 213 > Corynebacterium glutamicum 25 < 220 > < 221 > CDS < 222 > (101) .. (1300) < 223 > RXN00842 < 400 > 591 ccttgtcgcg igaggtaagieg aigggt.atttic tggatgtgga acaacgcgga -ttatiggaaaa 60 tcgtgacttt ieataacgttg agectactaa ggtttgttcc atg att att caa ate 115 Met He He Gln He 1 5 cta aga gtg gca ttt gcc ttc gtc ggc ate att gtt ggc gcc ggt ttc 163 Leu Arg Val Ala Phe Ala Phe Val Gly He He Val Gly Ala Gly Phe 10 15 20 gca tca ggg caa gag gtc atg caa tat ttt gtg gcc ttc ggc ata gac 211 Wing Ser Gly Gln Glu Val Met Gln Tyr Phe Val Wing Phe Gly He Asp 25 30 35 gga att tgg gga gtc att gtt tet gca gtg ate atg tcg gtg atg gcg 259 Gly He Trp Gly Val He Val Val Ala Wing Met Met Ser Val Met Wing 40 45 50 ttg ate att ttg cag etc gga age tat ttc aat gca ggt gaa falls ggt 307 Leu He He Leu Gln Leu Gly Ser Tyr Phe Asn Wing Gly Glu His Gly 55 60 65 gaa gtg ttc cgc cga gta agt drops ccc gtt ttc tcc aaa att ttg gac 355 Glu Val Phe Arg Arg Val Ser His Pro Val Phe Ser Lys He Leu Asp 70 75 80 85 ate ggc gtt gtg gtg acg ttg ttc tcc acc ggt ttc gtc atg ttt gca 403 He Gly Val Val Val Thr Leu Phe Ser Thr Gly Phe Val Met Phe Wing 90 95 100 ggc gc gga tca aat ctg aat cag tgg ggg ctt ccg etc tgg ate 451 Gly Ala Gly Ser Asn Leu Asn Gln Gln Trp Gly Leu Pro Leu Trp He 105 110 115 ggt tet gtg ate atg gtt ctt ctg gtg ctg gct gcg ggc atg ttg gac 499 Gly Ser Val He Met Val Leu Leu Val Leu Ala Wing Gly Met Leu Asp 120 125 130 gtg gat aaa gta acc gtc att ggt gca att act ccg ttc ate ate 547 Val Asp Lys Val Thr Thr Val He Gly Wing He Thr Pro Phe He He 135 140 145 att ttc ate act gcc gcc tcg ate tac acg ctg gta ggt aat ttc age 595 He Phe He Thr Wing Wing Being He Tyr Thr Leu Val Gly Asn Phe Being 150 155 160 165 tca gtg gag cag ctt gat tet gct gct tta gaa gtc ggc acg acg ttg 643 Ser Val Glu Gln Leu Asp Ser Ala Ala Leu Glu Val Gly Thr Thr Leu 170 175 180 ect falls tgg gct gtt gcg gtg aac tat gtg gga ttc aac ctg atg 691 Pro His Trp Wing Val Wing Wing Val Asn Tyr Val Gly Phe Asn Leu Met 185 190 195 gtt gcg gtg tcc atg gct gtg gtc att ggt gga tca atg ttt aac ccg 739 Val Ala Val Ser Met Ala Val Val He Gly Gly Ser Met Phe Asn Pro 200 205 210 cgg gtc gca ggt cgg ggc ggt ttg ctg ggc gga ttg ate ctg gga ttc 787 Arg Val Wing Gly Arg Gly Gly Leu Leu Gly Gly Leu He Leu Gly Phe 215 220 225 ttg ate ate ate agt gcg cta here ctg ttc gcc acc gtg gaa gaa gtt 835 Leu He He He Be Wing Leu Thr Leu Phe Wing Thr Val Glu Glu Val 230 235 240 245 ggc caa gat gat atg ect atg ctg ac ate ate aac aat ttg aac ccg 883 Gly Gln Asp Asp Met Pro Met Leu Thr He He Asn Asn Leu Asn Pro 4 ¿rft¿ M; 250 255 260 ctg gct ggc caa gta atg gca gtg gtt ate tac gga atg ate ttc aac 931 Leu Ala Gly Gln Val Met Ala Val Val He Tyr Gly Met He Phe Asn 265 270 275 acg gca ctg ggt atg ttc tac gca ttg ggc cgt cgt etc act gcg aaa 979 Thr Ala Leu Gly Met Phe Tyr Ala Leu Gly Arg Arg Leu Thr Ala Lys 280 285 290 aac cca cag cga tcc cgt ccg gtt tat gtg gtc here gtg ctg att ggt 1027 Asn Pro Gln Arg Phe Arg Pro Val Tyr Val Val Thr Val Leu He Gly • 295 300 305 ttt gtg ttg age ttt gtg gga ttc aag aac ttg gtg ggc tat gtg tac 1075 Phe Val Leu Ser Phe Val Gly Phe Lys Asn Leu Val Gly Tyr Val Tyr 310 315 320 325 cca gtc ttg gga tac att ggc ctg ctg ctg att gca gtg atg atg gtg 1123 Pro Val Leu Gly Tyr He Gly Leu Leu Leu He Wing Val Met Met Val 330 335 340 gcg tgg ggg agg gga cgc gta cgc ate tac aag gaa tcc gaa cgc cgc 1171 Wing Trp Val Arg Gly Arg Val Arg He Tyr Lys Glu Ser Glu Arg Arg 345 350 355 atg cgg ate gca gac ttg ttg cag ate ggc cat gac gga gcg ttg agt 1219 Met Arg He Wing Asp Leu Leu Gln He Gly His Asp Gly Wing Leu Ser 10 360 365 370 gga gca gag ctg gcg gtg etc aac cag gaa ate caa gat tca aac ttg 1267 Gly Wing Glu Leu Wing Val Leu Asn Gln Glu He Gln Asp Being Asn Leu 375 380 385 gat gag gaa caa att aaa gca gcg gtt agg aag tagttactet gcagggacga 1320 Asp Glu Glu Gln He Lys Ala Wing Val Arg Lys 390 395 400 gct 1323 < 210 > 592 < 211 > 400 < 212 > PRT 15 < 213 > Corynebacterium glutamicum < 400 > 592 Met He He Gln He Leu Arg Val Wing Phe Wing Phe Val Gly He He 1 5 10 15 Val Gly Wing Gly Phe Wing Being Gly Gln Glu Val Met Gln Tyr Phe Val 20 25 30 Wing Phe Gly He Asp Gly He Trp Gly Val He Val Val Ala Wing • 35 40 45 Met Ser Val Met Wing Leu He He Leu Gln Leu Gly Ser Tyr Phe Asn 50 55 60 20 Wing Gly Glu His Gly Glu Val Phe Arg Arg Val Ser His Pro Val Phe 65 70 75 80 Ser Lys He Leu Asp He Gly Val Val Val Thr Leu Phe Ser Thr Gly 85 90 95 Phe Val Met Phe Ala Gly Ala Gly Ser Asn Leu Asn Gln Gln Trp Gly 100 105 110 Leu Pro Leu Trp He Gly Ser Val He Met Val Leu Leu Val Leu Wing 115 120 125 Wing Gly Met Leu Asp Val Asp Lys Val Thr Thr Val He Gly Wing He 130 135 140 Thr Pro Phe He He He He Phe He Thr Wing Wing He He Tyr Thr Leu 145 150 155 160 25 Val Gly Asn Phe Ser Val Glu Gln Leu Asp Being Ala Ala Leu Glu t. l -k. -i 165 170 175 Val Gly Thr Thr Leu Pro His Trp Wing Val Wing Wing Val Asn Tyr Val 180 185 190 Gly Phe Asn Leu Met Val Wing Val Ser Met Wing Val Val He Gly Gly 195 200 205 Ser Met Phe Asn Pro Arg Val Wing Gly Arg Gly Gly Leu Leu Gly Gly 210 215 220 Leu He Leu Gly Phe Leu He He He Be Wing Leu Thr Leu Phe Wing 225 230 235 240 • Thr Val Glu Glu Val Gly Gln Asp Asp Met Met Met Leu Thr He He 245 250 255 Asn Asn Leu Asn Pro Leu Wing Gly Gln Val Met Wing Val Val He Tyr 260 265 270 Gly Met He Phe Asn Thr Wing Leu Gly Met Phe Tyr Wing Leu Gly Arg 275 280 285 Arg Leu Thr Wing Lys Asn Pro Gln Arg Phe Arg Pro Val Tyr Val Val 290 295 300 Thr Val Leu He Gly Phe Val Leu Ser Phe Val Gly Phe Lys Asn Leu 305 310 315 320 Val Gly Tyr Val Tyr Pro Val Leu Gly Tyr He Gly Leu Leu Leu He 10 325 330 335 Wing Val Met Met Val Wing Trp Val Arg Gly Arg Val Arg He Tyr Lys 340 345 350 Glu Ser Glu Arg Arg Met Arg He Wing Asp Leu Leu Gln He Gly His 355 360 365 Asp Gly Ala Leu Ser Gly Ala Glu Leu Ala Val Leu Asn Gln Glu He 370 375 380 Gln Asp Ser Asn Leu Asp Glu Glu Gln He Lys Ala Wing Val Arg Lys 385 390 395 400 < 210 > 593 < 211 > 1323 15 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1300) < 223 > FRXA00842 < 400 > 593 • ccttgtcgcg gaggtaagcg a < gggtatttc tggatgtgga acaacgcgga ttatggaaaa 60 tcgtgacttt cataacgttg atgeetactaa ggtttgttcc atg att att caa ate 115 Met He He Gln He 20 1 5 cta aga gtg gca ttt gcc ttc gtc ggc ate att gtt ggc gcc ggt ttc 163 Leu Arg Val Ala Phe Ala Phe Val Gly He He Val Gly Wing Gly Phe 10 15 20 gca tca ggg caa gag gtc atg caa tat ttt gtg gcc tcc ggc ata gac 211 Wing Ser Gly Gln Glu Val Met Gln Tyr Phe Val Wing Phe Gly He Asp 25 30 35 gga att tgg gga gtc att gtt tet gca gtg ate atg tcg gtg atg gcg 259 Gly He Trp Gly Val He Val Ser Wing Val He Met Ser Val Met Wing 40 45 50 ttg ate att ttg cag etc gga age tat ttc aat gca ggt gaa falls ggt 307 Leu He He Leu Gln Leu Gly Ser Tyr Phe Asn Wing Gly Glu His Gly 25 55 60 65 . d t AA, gaa gtg ttc cgc cga gta agt falls ccc gtt ttc tcc aaa att ttg gac 355 Glu Val Phe Arg Arg Val Ser His Pro Val Phe Ser Lys He Leu Asp 70 75 80 85 ate ggc gtt gtg gtg acg ttg ttc tcc acc ggt ttc gtc atg ttt gca 403 He Gly Val Val Val Thr Leu Phe Ser Thr Gly Phe Val Met Phe Wing 90 95 100 ggc gc gga tca aat ctg aat cag tgg ggg ctt ccg etc tgg ate 451 Gly Ala Gly Ser Asn Leu Asn Gln Gln Trp Gly Leu Pro Leu Trp He 105 110 115 • ggt tet gtg ate atg gtt ctt ctg gtg ctg gct gcg ggc atg ttg gac 499 Gly Ser Val He Met Val Leu Leu Val Leu Ala Wing Gly Met Leu Asp 120 125 130 gtg gat aaa gta acc gtc att ggt gca att act ccg ttc ate ate 547 Val Asp Lys Val Thr Thr Val He Gly Wing He Thr Pro Phe He He 135 140 145 att ttc ate act gcc gcc tcg ate tac acg ctg gta ggt aat ttc age 595 He Phe He Thr Wing Wing He He Tyr Thr Leu Val Gly Asn Phe Ser 150 155 160 165 tca gtg gag cag ctt gat tet gct gct tta gaa gtc ggc acg acg ttg 643 Ser Val Glu Gln Leu Asp Ser Ala Ala Leu Glu Val Gly Thr Thr Leu 10 170 175 180 ect falls tgg gct gtt gcg gtg aac tat gtg gga ttc aac ctg atg 691 Pro His Trp Wing Val Wing Wing Val Asn Tyr Val Gly Phe Asn Leu Met 185 190 195 • gtt gcg gtg tcc atg gct gtg gtc att ggt gga tca atg ttt aac ccg 739 Val Ala Val Ser Met Ala Val Val He Gly Gly Ser Met Phe Asn Pro 200 205 210 cgg gtc gca ggt cgg ggc ggt ttg ctg ggc gga ttg ate ctg gga ttc 787 Arg Val Wing Gly Arg Gly Gly Leu Leu Gly Gly Leu He Leu Gly Phe 215 220 225 ttg ate ate ate agt gcg cta here ctg ttc gcc acc gtg gaa gaa gtt 835 Leu He He He Be Wing Leu Thr Leu Phe Wing Thr Val Glu Glu Val 230 235 240 245 15 ggc ca gt gat atg ect atg ctg acg ate ate aac aat ttg aac ccg 883 Gly Gln Asp Asp Met Pro Met Leu Thr He He Asn Asn Leu Asn Pro 250 255 260 ctg gct ggc caa gta atg gca gtg gtt ate tac gga atg ate ttc aac 931 Leu Ala Gly Gln Val Met Ala Val Val He Tyr Gly Met He Phe Asn 265 270 275 acg gca ctg ggt atg ttc tac gca ttg ggc cgt cgt etc act gcg aaa 979 Thr Ala Leu Gly Met Phe Tyr Ala Leu Gly Arg Arg Leu Thr Ala Lys • 280 285 290 aac cca cag cga ttc cgt ccg gtt tat gtg gtc here gtg ctg att ggt 1027 Asn Pro Gln Arg Phe Arg Pro Val Tyr Val Val Thr Val Leu He Gly 295 300 305 20 ttt gtg ttg age ttt gtg gga ttc aag aac ttg gtg ggc tat gtg tac 1075 Phe Val Leu Ser Phe Val Gly Phe Lys Asn Leu Val Gly Tyr Val Tyr 310 315 320 325 cca gtc ttg gga tac att ggc ctg ctg ctg att gca gtg atg atg gtg 1123 Pro Val Leu Gly Tyr He Gly Leu Leu Leu He Wing Val Met Met Val 330 335 340 gcg tgg ggg agg gga cgc gta cgc ate tac aag gaa tcc gaa cgc cgc 1171 Wing Trp Val Arg Gly Arg Val Arg He Tyr Lys Glu Ser Glu Arg Arg 345 350 355 atg cgg ate gca gac ttg ttg cag ate ggc cat gac gga gcg ttg agt 1219 Met Arg He Wing Asp Leu Leu Gln He Gly His Asp Gly Wing Leu Ser 360 365 370 25 gga gca gag ctg gcg gtg etc aac cag gaa ate caa gat tca aac ttg 1267 Gly Wing Glu Leu Wing Val Leu Asn Gln Glu He Gln Asp Being Asn Leu 375 380 385 gat gag gaa caa att aaa gca gcg gtt agg aag tagttactet gcagggacga 1320 Asp Glu Glu Gln He Lys Ala Wing Val Arg Lys 390 395 400 gct 1323 < 210 > 594 • < 211 > 400 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 594 Met He He Gln He Leu Arg Val Wing Phe Wing Phe Val Gly He He 1 5 10 15 Val Gly Wing Gly Phe Wing Being Gly Gln Glu Val Met Gln Tyr Phe Val 20 25 30 Wing Phe Gly He Asp Gly He Trp Gly Val He Val Val Ala Wing 35 40 45 Met Ser Val Met Ala Leu He He Leu Gln Leu Gly Ser Tyr Phe Asn 10 50 55 60 Wing Gly Glu His Gly Glu Val Phe Arg Arg Val Ser His Pro Val Phe 65 70 75 80 • Be Lys He Leu Asp He Gly Val Val Val Thr Leu Phe Ser Thr Gly 85 90 95 Phe Val Met Phe Ala Gly Ala Gly Ser Asn Leu Asn Gln Gln Trp Gly 100 105 110 Leu Pro Leu Trp He Gly Ser Val He Met Val Leu Leu Val Leu Wing 115 120 125 Wing Gly Met Leu Asp Val Asp Lys Val Thr Thr Val He Gly Wing He 130 135 140 Thr Pro Phe He He He Phe He Thr Wing Wing He He Tyr Thr Leu 15 145 150 155 160 Val Gly Asn Phe Ser Ser Val Glu Gln Leu Asp Ser Wing Ala Leu Glu 165 170 175 Val Gly Thr Thr Leu Pro His Trp Wing Val Wing Wing Val Asn Tyr Val 180 185 190 Gly Phe Asn Leu Met Val Wing Val Ser Met Wing Val Val He Gly Gly 195 200 205 Ser Met Phe Asn Pro Arg Val Wing Gly Arg Gly Gly Leu Leu Gly Gly • 210 215 220 Leu He Leu Gly Phe Leu He He He Be Wing Leu Thr Leu Phe Wing 225 230 235 240 Thr Val Glu Glu Val Gly Gln Asp Asp Met Pro Met Leu Thr He He 20 245 250 255 Asn Asn Leu Asn Pro Leu Wing Gly Gln Val Met Wing Val Val He Tyr 260 265 270 Gly Met He Phe Asn Thr Wing Leu Gly Met Phe Tyr Wing Leu Gly Arg 275 280 285 Arg Leu Thr Wing Lys Asn Pro Gln Arg Phe Arg Pro Val Tyr Val Val 290 295 300 Thr Val Leu He Gly Phe Val Leu Ser Phe Val Gly Phe Lys Asn Leu 305 310 315 320 Val Gly Tyr Val Tyr Pro Val Leu Gly Tyr He Gly Leu Leu Leu He 325 330 335 Wing Val Met Met Val Wing Trp Val Arg Gly Arg Val Arg He Tyr Lys 25 . ^ ^? ^? iL. 340 345 350 Glu Ser Glu Arg Arg Met Arg He Wing Asp Leu Leu Gln He Gly His 355 360 365 Asp Gly Wing Leu Ser Gly Wing Glu Leu Wing Val Leu Asn Gln Glu He 370 375 380 Gln Asp Ser Asn Leu Asp Glu Glu Gln He Lys Ala Ala Val Arg Lys 385 390 395 400 < 210 > 595 • < 211 > 1173 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1150) < 223 > RXN00832 < 400 > 595 gagattgtge taggttctga tgaggcttcg ggacgacccg aagaaatcta tgacagcctg 60 ggaacggccc agagttetta agaaagtttg actagagaac atg ccg ttt tet tgg 115 10 Met Pro Phe Ser Trp 1 5 cta aaa cca att gat tat gcc cgc ate ttt gtc ggc tgg gca tcg att 163 Leu Lys Pro He Asp Tyr Ala Arg He Phe Val Gly Trp Ala Ser He 10 15 20 ttt ate ate ccc etc ate here ctg cca tca att att gag ttg gcg ctg 211 Phe He He Pro Leu He Thr Leu Pro Ser He He Glu Leu Ala Leu 25 30 35 ate gtg gca gtc ate cta ttc tgc gca ttt ggc gtg gtg aag atg gcg 259 He Val Ala Val He Leu Phe Cys Wing Phe Gly Val Val Lys Met Wing 40 45 50 gag cgt ttg gct cat att ttg ggt gat ect ttt gga tcg ttg ate ctt 307 15 Glu Arg Leu Ala His He Leu Gly Asp Pro Phe Gly Ser Leu He Leu 55 60 65 acc ttg tcg ate gtg ate att gaa gtg att ttg ate tgt gcg gtg atg 355 Thr Leu Ser He Val He He Glu Val He Leu He Cys Wing Val Met 70 75 80 85 ctg ggg ect gct gat tca acc act gct ggt cgg gat tcc gtg atg gca 403 Leu Gly Pro Wing Asp Ser Thr Thr Wing Gly Arg Asp Ser Val Met Wing 90 95 100 • gtg tcc atg ate ate atg ggt ttg gtc gtg gtg gga ttg tgc cta etc att 451 Val Ser Met He Met Met Gly Leu Val Val Gly Leu Cys Leu Leu He 105 110 115 ggt ggt tta agg cat gga age atg cca cae aat ggg gtg gga act ccg 499 20 Gly Gly Leu Arg His Gly Ser Met Pro His Asn Gly Val Gly Thr Pro 120 125 130 acc tac ttg gtg ctg ate gca act ttt gta ate gcc ttt gcg gtt 547 Thr Tyr Leu Val Leu He Wing Thr Phe Ser Val He Wing Phe Wing Val 135 140 145 cca gct ttc agg gga gaa tac tcc act ggg cag gca ctt gtt att tca 595 Pro Ala Phe Arg Gly Glu Tyr Ser Thr Gly Gln Ala Leu Val He Ser 150 155 160 165 here ctg here gca gtg gtg tac ggg ttc ttc ctg ttt cgc caa atg ggt 643 Thr Leu Thr Wing Val Val Tyr Gly Phe Phe Leu Phe Arg Gln Met Gly 170 175 180 gcc caa gct ggt gaa ttt caa gag gtc gag gtc gca gaa aag gca gac 691 25 ^^^ ^ m ^ g Ala Gln Ala Gly Glu Phe Gln Glu Val Glu Val Ala Glu Lys Ala Asp 185 190 195 gac gca gca aaa tgg gag gtc cca ttt aga ggc tta ate ttg att ate 739 Asp Wing Wing Lys Trp Glu Val Pro Phe Arg Gly Leu He Leu He He 200 205 210 act gtg etc ccc ate gtg ttg ctg tcc cat gac atg gcc acg gtg atg 787 Thr Val Leu Pro He Val Leu Leu Ser His Asp Met Wing Thr Val Met 215 220 225 gat gaa gtc ctg gca age ctt ggt gca ccc gta gca atg gct gga tta 835 Asp Glu Val Leu Wing Ser Leu Gly Ala Pro Val Wing Met Wing Gly Leu 230 235 240 245 att att gcc acc att gtc ttc ttg cca gag acc ate acc tcc ttg aaa 883 He He Ala Thr He Val Phe Leu Pro Glu Thr He Thr Ser Leu Lys 250 255 260 gct gcg tgg here gga gag att cag cga gta age aac etc gcg cat gga 931 Ala Ala Trp Thr Gly Glu He Gln Arg Val Ser Asn Leu Ala His Gly 265 270 275 gcc caa gta tca acg gtg ggg ctg here ate cca gct gtt cta gtg ate 979 Wing Gln Val Ser Thr Val Gly Leu Thr He Pro Wing Val Leu Val He 280 285 290 ggc gtg ate here ggt caa gat gta gtt ttg 1027 10 ggg gag acc ccg ate aac Gly Val He Thr Gly Gln Asp Val Val Leu Gly Glu Thr Pro He Asn 295 300 305 ttg ttg ctg ctg gga acc acc att gcg gtg here gcc att gcg ttt age 1075 • Leu Leu Leu Leu Gly Thr Thr He Wing Val Thr Wing Wing Phe Ser 310 315 320 325 tcc aa aa aa gtc agt gct gtc cat gcc tcg gtg ctg etc atg ctt ttc 1123 Ser Lys Lys Val Ser Wing Val His Gly Ser Val Leu Leu Met Leu Phe 330 335 340 ggt gtt tac atg age atg ttc gcc tgatttaggt agcctggtgg 1170 Gly Val Tyr Met Met Met Met Phe Wing 345 350 gaa 1173 15 < 210 > 596 < 211 > 350 < 212 > PRT < 213 > Corynebact: erium glutamicum < 400 > 596 Met Pro Phe Ser Trp Leu Lys Pro He Asp Tyr Wing Arg He Phe Val • 1 5 10 15 Gly Trp Wing Being He Phe He He Pro Leu He Thr Leu Pro Being He 20 25 30 He Glu Leu Wing Leu He Val Wing Val He Leu Phe Cys Wing Phe Gly 20 35 40 45 Val Val Lys Met Wing Glu Arg Leu Wing His He Leu Gly Asp Pro Phe 50 55 60 Gly Ser Leu He Leu Thr Leu Ser He Val He He Glu Val He Leu 65 70 75 80 He Cys Wing Val Met Leu Gly Pro Wing Asp Ser Thr Thr Wing Gly Arg 85 90 95 Asp Ser Val Met Wing Val Ser Met He Met Met Gly Leu Val Val Gly 100 105 110 Leu Cys Leu Leu He Gly Gly Leu Arg His Gly Ser Met Pro His Asn 115 120 125 Gly Val Gly Thr Pro Thr Tyr Leu Val Leu He Wing Thr Phe Ser Val 25 130 135 140 He Ala Phe Ala Val Pro Ala Phe Arg Gly Glu Tyr Ser Thr Gly Gln 145 150 155 160 Ala Leu Val He Be Thr Leu Thr Wing Val Val Tyr Gly Phe Phe Leu 165 170 175 Phe Arg Gln Met Gly Wing Gln Wing Gly Glu Phe Gln Glu Val Glu Val 180 185 190 Wing Glu Lys Wing Asp Asp Wing Wing Lys Trp Glu Val Pro Phe Arg Gly 195 200 205 • Leu He Leu He He Thr Val Leu Pro He Val Leu Leu Ser His Asp 210 215 220 Met Wing Thr Val Met Asp Glu Val Leu Wing Ser Leu Gly Wing Pro Val 225 230 235 240 Wing Met Wing Gly Leu He He Wing Thr He Wing Val Phe Leu Pro Glu Thr 245 250 255 He Thr Ser Leu Lys Wing Wing Trp Thr Gly Glu He Gln Arg Val Ser 260 265 270 Asn Leu Wing His Gly Wing Gln Val Ser Thr Val Gly Leu Thr He Pro 275 280 285 Wing Val Leu Val He Gly Val He Thr Gly Gln Asp Val Val Leu Gly 290 295 300 10 Glu Thr Pro He Asn Leu Leu Leu Leu Gly Thr Thr He Wing Val Thr 305 310 315 320 Wing He Wing Phe Ser Ser Lys Lys Val Ser Wing Val His Gly Ser Val • 325 330 335 Leu Leu Met Leu Phe Gly Val Tyr Met Met Ser Met Phe Wing 340 345 350 <; 210 > 597 < 211 > 1119 < 212 > DNA < 213 > Corynebacterium glutamicum 15 < 220 > < 221 > CDS < 222 > (101) .. (1096) < 223 > RXN00466 < 400 > 597 ttt; aaaagcg cactaagagc tcgtcaattt; tttaaaacaa getgagaatg tgaataatag 60 gat; aggttaa cctgattcga ttagaaaactg gagatttgtc gtg caa tcc cgc ctg 115• Val Gln Ser Arg Leu 1 5 tcc aaa ate ctg cgc agt age gtc gta ggc gtt gct gtc cta gcc ctg 163 Ser Lys He Leu Arg Ser Ser Val Val Gly Val Ala Val Leu Ala Leu 20 10 15 20 tta gct ggg tgt tet aac aat gca gat gac acc gac gct gat tca here 211 Leu Wing Gly Cys Ser Asn Asn Wing Asp Asp Thr Asp Wing Asp Ser Thr 25 30 35 tcc acg gga aac tcc gct ttt ect gtt tcg att gaa cae gag ttc gga 259 Be Thr Gly Asn Be Wing Phe Pro Val Ser He Glu His Glu Phe Gly 40 45 50 acc accà ac ate gat gat gta ccc gaa aga gtt gtc acc ctt ggc gtt 307 Thr Thr As Asp Asp Val Pro Glu Arg Val Val Thr Leu Gly Val 55 60 65 acc gac gcc gat att gtc etc gca ttg ggg acc gtc cca gta ggc aac 355 Thr Asp Wing Asp He Val Leu Wing Leu Gly Thr Val Pro Val Gly Asn 25 70 75 80 85 acc gga tac aaa ttc ttc gaa aac gga ttg gga ccg tgg act gat gag 403 Thr Gly Tyr Lys Phe Phe Glu Asn Gly Leu Gly Pro Trp Thr Asp Glu 90 95 100 tta gtg gaa ggc aaa gaa tta here ctg ctt gac tet gat aka here cca 451 Leu Val Glu Gly Lys Glu Leu Thr Leu Leu Asp Ser Asp Ser Thr Pro 105 110 115 gat ctt gaa gca gta caa gcc CTG gag cca gac CTG att att gga gtc 499 Asp Leu Glu Gln Val Ala Ala Leu Glu Pro Asp Leu I've Gly Val 120125130 tet GCG ggg ttt gac gac GTT gta tac gag caa cta tet gat ate GCA 547 Ser Ala Gly Phe Asp Asp Val Val Tyr Glu Gln Leu Ser Asp He Wing 135 140 145 ccg gtg gtc gcc cgt cca gcg gga here gct gca tac gca gta gct cgc 595 Pro Val Val Ala Arg Pro Ala Gly Thr Ala Ala Tyr Ala Val Ala Arg 150 155 160 165 gag gaa gct acc aac ctt gtt gcc cgt gcg atg ggg caa tca gaa aaa 643 Glu Glu Wing Thr Asn Leu Val Wing Arg Wing Met Gly Gln Ser Glu Lys 170 175 180 gga caa gag etc aat gag gaa here ga t gct ctg ate caa gct gcg cgt 691 Gly Gln Glu Leu Asn Glu Glu Thr Asp Ala Leu He Gln Ala Ala Arg 185 190 195 gat gaa aat ect tet ttt gac ggt aaa here gga acc gtc ate ttg cca 739 Asp Glu Asn Pro Ser Phe Asp Gly Lys Thr Gly Thr Val He Leu Pro 200 205 210 tac cag ggt aaa tac ggt gcc tac ctg cca ggc gat gca gga cgg caa 787 Tyr Gln Gly Lys Tyr Gly Ala Tyr Leu Pro Gly Asp Ala Arg Gly Gln 215 220 225 ttc etc gat tca ctt ggc att tcg ctg ccg gaa gca gtt ctt tcg cga 835 Phe Leu Asp Ser Leu Gly He Ser Leu Pro Glu Ala Val Leu Ser Arg 230 235 240 245 gac acc ggc gac age ttc ttt gtc gat gtc ccc gct gaa age gtc aaa 883 Asp Thr Gly Asp Ser Phe Phe Val Asp Val Pro Wing Glu Ser Val Lys 250 255 260 gac gta gac ggt gat gtt etc etc gtg ctt tcc aac gac gaat aat ctg 931 Asp Val Asp Gly Asp Val Leu Leu Val Leu Being As Asp Glu Asn Leu 265 270 275 gat ate here gca gag aat cca ctg ttt gaa here etc aac gtt gtg caa 979 Asp He Thr Wing Glu Asn Pro Leu Phe Glu Thr Leu Asn Val Val Gln 280 285 290 aa to gac gta gca att gtg gca here acc gaa gaa cgc ggg gcg att acc 1027 Lys Asp Ala Val He Val Ala Thr Thr Glu Glu Arg Gly Ala He Thr 295 300 305 tac aac tca gtg ctg tet gtt ect ttt gcg ttg gaa cat etc gca cca 1075 Tyr Asn Ser Val Leu Ser Val Pro Phe Wing Leu Glu His Leu Wing Pro 310 315 320 325 cgt att gct gag gct ttg aag taaaactcaa ctactcgagc here 1119 Arg He Ala Glu Ala Leu Lys 330 < 210 > 598 < 211 > 332 < 212 > PRT < 213 > Cc > rynebactepum glutamicum < 400 > 598 Val Gln Ser Arg Leu Ser Lys He Leu Arg Ser Ser Val Val Gly Val 1 5 10 15 Wing Val Leu Wing Leu Leu Wing Gly Cys Ser Asn Asn Wing Asp Asp Thr 20 25 30 Asp Wing Asp Ser Thr Ser Thr Gly Asn Ser Wing Phe Pro Val Ser He 35 40 45 Glu His Glu Phe Gly Thr Thr Thr He Asp Asp Val Pro Glu Arg Val 50 55 60 Val Thr Leu Gly Val Thr Asp Wing Asp He Val Leu Wing Leu Gly Thr 65 70 75 80 • Val Pro Val Gly Asn Thr Gly Tyr Lys Phe Phe Glu Asn Gly Leu Gly 85 90 95 Pro Trp Thr Asp Glu Leu Val Glu Gly Lys Glu Leu Thr Leu Leu Asp 100 105 110 Ser Asp Ser Thr Pro Asp Leu Glu Gln Val Ala Ala Ala Leu Glu Pro Asp 115 120 125 Leu He He Gly Val Ser Wing Gly Phe Asp Asp Val Val Tyr Glu Gln 130 135 140 Leu Ser Asp He Wing Pro Val Val Wing Arg Pro Wing Gly Thr Wing Wing 145 150 155 160 Tyr Wing Val Wing Arg Glu Glu Wing Thr Asn Leu Val Wing Arg Wing Met 165 170 175 10 Gly Gln Ser Glu Lys Gly Gln Glu Leu Asn Glu Glu Thr Asp Ala Leu 180 185 190 He Gln Wing Wing Arg Asp Glu Asn Pro Ser Phe Asp Gly Lys Thr Gly • 195 200 205 Thr Val He Leu Pro Tyr Gln Gly Lys Tyr Gly Wing Tyr Leu Pro Gly 210 215 220 Asp Wing Arg Gly Gln Phe Leu Asp Ser Leu Gly He Ser Leu Pro Glu 225 230 235 240 Wing Val Leu Ser Arg Asp Thr Gly Asp Ser Phe Phe Val Asp Val Pro 245 250 255 Wing Glu Ser Val Lys Asp Val Asp Gly Asp Val Leu Leu Val Leu Ser 260 265 270 15 Asn Asp Glu Asn Leu Asp He Thr Wing Glu Asn Pro Leu Phe Glu Thr 275 280 285 Leu Asn Val Val Gln Lys Asp Wing Val He Val Wing Thr Thr Glu Glu 290 295 300 Arg Gly Wing He Thr Tyr Asn Ser Val Leu Ser Val Pro Phe Wing Leu 305 310 315 320 Glu His Leu Wing Pro Arg He Wing Glu Wing Leu Lys 325 330 <; 210 > 599 < 211 > 1395 < 212 > DNA 20 < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1372) < 223 > RXN01936 < 400 > 599 gcgcggtgac accacagccg ttgtcagcgg egettggtet gtggaggatc gccgaggtta 60 ctaacaaata ggcccaacaa agaggtctaa gctctacctg gtg agt ttc cga gat 115 Val Ser Phe Arg Asp 1 5 25 att ttc gct gac acc aga ccg ctg aaa gaa ccg gcc ttc aaa cgc etc 163 He Phe Wing Asp Thr Arg Pro Leu Lys Glu Pro Wing Phe Lys Arg Leu 10 15 20 tgg ctt ggc aat gtt gcc gtc acc att ggt gcc gt caa tta act gtt gtt 211 Trp Leu Gly Asn Val Wing Thr Val He Gly Wing Gln Leu Thr Val Val 25 30 35 gcc gtt ccg gtg cag att tac caa atg act ggg tcc tc ggc tat gtg 259 Wing Val Pro Val Gln He Tyr Gln Met Thr Gly Ser Ser Gly Tyr Val 40 45 50 ggc ttg acc ggg ctt ttt ggc ctt att ect ttg gtt att ttt ggc ctt 307 Gly Leu Thr Gly Leu Phe Gly Leu He Pro Leu Val He Phe Gly Leu 55 60 65 tat ggt gga tcc att gcg gat gct ttt gat aaa cgc ate gtg ctg ate 355 Tyr Gly Gly Ser He Wing Asp Wing Phe Asp Lys Arg He Val Leu He 70 75 80 85 tgc acc acg ate ggc atg tgt gtc acc act gcc gtt ttt tgg gtg ctg 403 Cys Thr Thr He Gly Met Cys Val Thr Thr Wing Gly Phe Trp Val Leu 90 95 100 acc att tta ggc aat gag aat att tgg etc ctg tta ata aac ttt tet 451 Thr He Leu Gly Asn Glu Asn He Trp Leu Leu Leu He Asn Phe Ser 105 110 115 tta cag cag gca ttt ttc gcg gtg aat caa ccc acc cga acg gcg ate 499 Leu Gln Gln Wing Phe Phe Wing Val Asn Gln Pro Thr Arg Thr Wing He 120 125 130 ctt cga agt att ttg ccg att gat caa tta gcg tcg gca here tca ctg 547 Leu Arg Ser He Leu Pro He Asp Gln Leu Ala Ser Ala Thr Ser Leu 135 140 145 aat atg ctg etc atg cag acc ggc gca ate gtt ggc ccg ctg ate gca 595 Asn Met Leu Leu Met Gln Thr Gly Ala He Val Gly Pro Leu He Ala 150 155 160 165 ggt gcg ttg att ccg ctg ate ggt ttc ggg tgg ctg tat ttc ctt gat 643 Gly Ala Leu He Pro Leu He Gly Phe Gly Trp Leu Tyr Phe Leu Asp 170 175 180 gtt gtc tcc ate ate ccc here ctg tgg gct tta gt tca ctg ect tcg 691 Val Val Ser He He Pro Thr Leu Trp Wing Val Trp Ser Leu Pro Ser 185 190 195 ate aag cca tcc ggc aag gtg atg aag gct gt t gc gtg gtg 739 He Lys Pro Ser Gly Lys Val Met Lys Wing Gly Phe Wing Ser Val Val 200 205 210 gat ggc ctg aag tat ttg gct ggc caa ccc gtg ttg ttg atg gtg atg 787 Asp Gly Leu Lys Tyr Leu Wing Gly Gln Pro Val Leu Leu Met Val Met 215 220 225 gtg ctg gat ctt ate gcc atg att ttc ggc atg cca cgt gcg ctt tac 835 Val Leu Asp Leu He Ala Met He Phe Gly Met Pro Arg Ala Leu Tyr 230 235 240 245 ccc gag ate gca gaa gtg aac ttc ggt ggg ggt gac gcc ggt gca ggt acg 883 Pro Glu He Wing Glu Val Asn Phe Gly Gly Gly Asp Wing Gly Wing Thr 250 255 260 atg ctg gcg ttc atg tac tca tcc atg gct gtt ggc gca gtt ctt ggc 931 Met Leu Wing Phe Met Tyr Ser Ser Met Wing Val Gly Wing Val Leu Gly 265 270 275 ggc gtg ctg tet ggt tgg gtg gcc cgg att age cgc cag ggt gtt gca 979 Gly Val Leu Ser Gly Trp Val Wing Arg He Ser Arg Gln Gly Val Wing 280 285 290 gtt tat tgg tgc ate ate gcc tgg ggc gca gcc gtt gct tg ggt ggt 1027 Val Tyr Trp Cys He He Wing Trp Gly Wing Wing Val Wing Leu Gly Gly 295 300 305 gtg gca att gtt gtc age ccc ggc gcg gtg act gcg tgg gcg tgg atg 1075 Val Ala He Val Val Ser Pro Gly Ala Val Thr Ala Trp Ala Trp Met 310 315 320 325 ttc ate ate atg atg gtc att ggt ggc atg gct gac atg ttc age tcg 1123 Phe He Met Met Met Val He Gly Met Gly Met Asp Met Phe Ser Ser 330 335 340 gca gtt cga aac gct att ttg cag cag tet gct gcg gaa cat gtg cag 1171 Wing Val Arg Asn Wing He Leu Gln Gln Wing Wing Wing Glu His Val Gln 345 350 355 • ggc cga ate caa ggt gtg tgg ate ate gtc gtg gtg ggt gga ect cgt 1219 Gly Arg He Gln Gly Val Trp He He Val Val Val Gly Gly Pro Arg 360 365 370 tta gct gac gtc ctt fall ggt tgg gcc gct gag ccc gcc etc ggc gca 1267 Leu Ala Asp Val Leu His Gly Trp Wing Wing Glu Pro Leu Gly Wing Gly 375 380 385 tgg acg gta tta tgg ggc gga gta gcg gtg gtt gta etc act gca att 1315 Trp Thr Val Leu Trp Gly Gly Val Wing Val Val Val Leu Thr Ala He 390 395 400 405 tgt atg gtg gcg gtg ect aaa ttc tgg aaa tac gag aaa cca aaa att 1363 Cys Met Val Wing Val Pro Lys Phe Trp Lys Tyr Glu Lys Pro Lys He 410 415 420 10 acc ggc ate taaatactta tccatgccca ttt 1395 Thr Gly He • < 210 > 600 < 211 > 424 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 600 Val Ser Phe Arg Asp He Phe Wing Asp Thr Arg Pro Leu Lys Glu Pro 1 5 10 15 15 Wing Phe Lys Arg Leu Trp Leu Gly Asn Val Wing Thr Val He Gly Wing 20 25 30 Gln Leu Thr Val Val Wing Val Pro Val Gln He Tyr Gln Met Thr Gly 35 40 45 Ser Gly Tyr Val Gly Leu Thr Gly Leu Phe Gly Leu He Pro Leu 50 55 60 Val He Phe Gly Leu Tyr Gly Gly Ser He Wing Asp Wing Phe Asp Lys 65 70 75 80 Arg He Val Leu He Cys Thr Thr He Gly Met Cys Val Thr Thr Wing 85 90 95 Gly Phe Trp Val Leu Thr He Leu Gly Asn Glu Asn He Trp Leu Leu 100 105 110 20 Leu He Asn Phe Ser Leu Gln Gln Wing Phe Phe Wing Val Asn Gln Pro 115 120 125 Thr Arg Thr Wing He Leu Arg Ser He Leu Pro He Asp Gln Leu Wing 130 135 140 Ser Wing Thr Ser Leu Asn Met Leu Leu Met Gln Thr Gly Wing He Val 145 150 155 160 Gly Pro Leu He Ala Gly Ala Leu He Pro Leu He Gly Phe Gly Trp 165 170 175 Leu Tyr Phe Leu Asp Val Val Ser He He Pro Thr Leu Trp Wing Val 180 185 190 Trp Ser Leu Pro Ser He Lys Pro Ser Gly Lys Val Met Lys Ala Gly 195 200 205 25 Phe Ala Ser Val Val Asp Gly Leu Lys Tyr Leu Ala Gly Gln Pro Val 210 215 220 Leu Leu Met Val Met Val Leu Asp Leu He Ala Met He Phe Gly Met 225 230 235 240 Pro Arg Ala Leu Tyr Pro Glu He Ala Glu Val Asn Phe Gly Gly Gly 245 250 255 Asp Wing Gly Wing Thr Met Leu Wing Phe Met Tyr Ser Ser Wing Wing Val 260 265 270 Gly Wing Val Leu Gly Gly Val Leu Ser Gly Trp Val Wing Arg He Ser • 275 280 285 Arg Gln Gly Val Wing Val Tyr Trp Cys He He Wing Trp Gly Wing Wing 290 295 300 Val Wing Leu Gly Gly Val Wing Val Val Ser Ser Gly Wing Val Thr 305 310 315 320 Wing Trp Wing Trp Met Phe He Met Met Met Val He Gly Gly Met Wing 325 330 335 Asp Met Phe Ser Wing Val Arg Asn Wing He Leu Gln Gln Ser Wing 340 345 350 Wing Glu His Val Gln Gly Arg He Gln Gly Val Trp He He Val Val 355 360 365 Val Gly Gly Pro Arg Leu Wing Asp Val Leu His Gly Trp Wing Ala Glu 10 370 375 380 Pro Leu Gly Wing Gly Trp Thr Val Leu Trp Gly Val Val Val Wing Val 385 390 395 400 • Val Leu Thr Wing He Cys Met Val Wing Val Pro Lys Phe Trp Lys Tyr 405 410 415 Glu Lys Pro Lys He Thr Gly He 420 <; 210 > 601 < 211 > 1461 < 212 > DNA < 213 > Corynebacterium glutamicum 15 < 220 > < 221 > CDS < 222 > (101) .. (1438) < 223 > RXN01995 < 400 > 601 ccgacgcaaa < ggcatgcgcc tegcgtgtctc gagtagtctc ctccccttcc tcgtccccaa 60 • cctcgaccat 1acggtcgcc ctctcctaaa ggagcctggc atg gat ate cgc caa 115 Met Asp He Arg Gln 1 5 here att aac gac here gca atg tcg aga tat cag tgg ttc att gta ttt 163 20 Thr He Asn Asp Thr Wing Met Ser Arg Tyr Gln Trp Phe He Val Phe 10 15 20 ate gca gtg ctg etc aac gca ctg gac ggc ttt gat gtc etc gcc atg 211 He Wing Val Leu Leu Asn Wing Leu Asp Gly Phe Asp Val Leu Ala Met 25 30 35 tet ttt act gcg aat gca gtg acc gaa ttt gga ctg agt ggc age 259 Ser Phe Thr Ala Asn Ala Val Thr Glu Glu Phe Gly Leu Ser Gly Ser 40 45 50 cag ctt ggt gtg ctg ctg agt tcc gcg ctg ttc ggc atg acc gct gga 307 Gln Leu Gly Val Leu Leu Ser Be Ala Leu Phe Gly Met Thr Ala Gly 55 60 65 tet ttg ctg ttc ggt ccg ate ggt gac cgt ttc ggc cgt aag aat gcc 355 25 Be Leu Leu Phe Gly Pro He Gly Asp Arg Phe Gly Arg Lys Asn Wing 70 75 80 85 ctg atg ate gcg ctg ctg ttc aac gtg gtg gga ttg gta ttg tcc gcc 403 Leu Met He Ala Leu Leu Phe Asn Val Val Gly Leu Val Leu Ser Wing 90 95 100 acc gcg cag tcc gca ggc cag ttg ggc gtg tgg cgt ttg ate act ggt 451 Thr Wing Gln Ser Wing Gly Gln Leu Gly Val Trp Arg Leu He Thr Gly 105 110 115 ate ggc ate ggc gga ate etc gcc tgc ate here gtg gtg ate agt gag 499 He Gly He Gly Gly He Leu Wing Cys He Thr Val Val He Ser Glu 120 125 130 tc tcc aac aaa aac cgc ggc atg gcc atg tcc ate ate gct gct 547 Phe Ser Asn Asn Lys Asn Arg Gly Met Wing Met Ser He Tyr Wing Wing 135 140 145 ggt tac ggc ate ggc gcg tcc tgc ggc ggt tgc ggc gca gcg cag etc 595 Gly Tyr Gly He Gly Wing Ser Leu Gly Gly Phe Gly Wing Wing Gln Leu 150 155 160 165 ate cca here ttt gga tgg cgc tcc gtg ttc gca gcc gcg ate gca 643 He Pro Thr Phe Gly Trp Arg Ser Val Phe Wing Wing Gly Wing Wing 170 175 180 act ggt ate gcc acc ate gct act ttc ttc ttc ctg cca gaa tc c gtt 691 Thr Gly He Wing Thr He Wing Thr Phe Phe Phe Leu Pro Glu Ser Val 185 190 195 gat tgg ctg age act cgc cgc ect gcg ggc gct cgc gac aag ate aat 739 Asp Trp Leu Ser Thr Arg Arg Pro Wing Ala Gly Arg Asp Lys He Asn 200 205 210 tac att gcg cgc cgc ctg ggc aaa gtc ggt acc ttt gag ctt cca cgc 787 Tyr He Wing Arg Arg Leu Gly Lys Val Gly Thr Phe Glu Leu Pro Gly 215 220 225 gaa caa age ttg tcg acg aaa aaa gcc ggt etc caa tcg tat gca gtg 835 Glu Gln Ser Leu Ser Thr Lys Lys Wing Gly Leu Gln Ser Tyr Wing Val 230 235 240 245 etc gtt aac aaa gag aac cgt gga acc age ate aag ctg tgg gtt gcg 883 Leu Val Asn Lys Glu Asn Arg Gly Thr Ser He Lys Leu Trp Val Wing 250 255 260 ttc ggc ate gtg atg ttc ggc ttc tac tcc gcc aac act tgg acc ccg 931 Phe Gly He Val Met Phe Gly Phe Tyr Phe Wing Asn Thr Trp Thr Pro 265 270 275 aag ctg etc gtg gaa acc gga atg tca gaa cag ggc ate ate ggt 979 Lys Leu Leu Val Glu Thr Gly Met Ser Glu Gln Gln Gly He He Gly 280 285 290 ggt ttg atg ttg tcc atg ggt gga gca ttc gg ctct ctg etc tac ggt 1027 Gly Leu Met Leu Ser Met Gly Gly Wing Phe Gly Ser Leu Leu Tyr Gly 295 300 305 ttc etc acc ac aag ttc age tcc cga aac here ctg atg acc ttc atg 1075 Phe Leu Thr Thr Lys Phe Ser Be Arg Asn Thr Leu Met Thr Phe Met 310 315 320 325 gtg ctg ctg gcc ccg acg ctg ate ctg ttc att tcc tcc acc tet gtt 1123 Val Leu Ser Gly Leu Thr Leu He Leu Phe He Ser Ser Thr Ser Val 330 335 340 cca tcc ate gcg ttt gcc age ggc gtt gtc gtg ggc atg ctg ate aat 1171 Pro Ser He Ala Phe Ala Ser Gly Val Val Val Gly Met Leu He Asn 345 350 355 ggt tgt gtg gct ggt ctg tac acc ctg tcc cca cag ctg tac tcc gct 1219 Gly Cys Val Wing Gly Leu Tyr Thr Leu Ser Pro Gln Leu Tyr Ser Wing 360 365 370 gaa gta cgc acc act ggt gtg ggc gct gcg att ggt atg ggt cgt gtc 1267 lai t, Glu Val Arg Thr Thr Gly Val Gly Ala Wing Gly Met Gly Arg Val 375 380 385 ggt gcg att tcc gcg cca ctg ctg gtg ggt ggc ctg ctg gat tet ggc 1315 Gly Ala He Ser Ala Pro Leu Leu Val Gly Gly Leu Leu Asp Ser Gly 390 395 400 405 tgg tcc cca acg cag ctg tat gtt ggt gtg gca gtg att gtt att gcc 1363 Trp Ser Pro Thr Gln Leu Tyr Val Gly Val Ala Val He Val He Wing 410 415 420 ggt gca acc gca ttg att ggg atg cgc act cag gcg gta gcc gtc gaa 1411 • Gly Ala Thr Ala Leu He Gly Met Arg Thr Gln Wing Val Wing Val Glu 425 430 435 aag cag ect gaa gcc cta gcg acc aaa tagggccgcg attectagea 1458 Lys Gln Pro Glu Ala Leu Ala Thr Lys 440 445 tgc 1461 < 210 > 602 < 211 > 446 < 212 > PRT < 213 > Corynebacterium glutamicum 10 < 400 > 602 Met Asp He Arg Gln Thr He Asn Asp Thr Wing Met Ser Arg Tyr Gln 1 5 10 15 • Trp Phe He Val Phe He Wing Val Leu Leu Asn Wing Leu Asp Gly Phe 20 25 30 Asp Val Leu Wing Met Ser Phe Thr Wing Asn Wing Val Thr Glu Glu Phe 35 40 45 Gly Leu Ser Gly Ser Gln Leu Gly Val Leu Leu Ser Wing Leu Phe 50 55 60 Gly Met Thr Ala Gly Ser Leu Leu Phe Gly Pro He Gly Asp Arg Phe 65 70 75 80 Gly Arg Lys Asn Ala Leu Met He Ala Leu Leu Phe Asn Val Val Gly 15 85 90 95 Leu Val Leu Ser Ala Thr Ala Gln Ser Ala Gly Gln Leu Gly Val Trp 100 105 110 Arg Leu He Thr Gly He Gly He Gly Gly He Leu Wing Cys He Thr 115 120 125 Val Val He Ser Glu Phe Ser Asn Asn Lys Asn Arg Gly Met Wing Met 130 135 140 Ser He Tyr Wing Wing Gly Tyr Gly He Gly Wing Ser Leu Gly Gly Phe • 145 150 155 160 Gly Ala Wing Gln Leu He Pro Thr Phe Gly Trp Arg Ser Val Phe Wing 165 170 175 Wing Gly Wing He Wing Thr Gly He Wing Thr He Wing Thr Phe Phe Phe 20 180 185 190 Leu Pro Glu Ser Val Asp Trp Leu Ser Thr Arg Arg Pro Wing Gly Ala 195 200 205 Arg Asp Lys He Asn Tyr He Wing Arg Arg Leu Gly Lys Val Gly Thr 210 215 220 Phe Glu Leu Pro Gly Glu Gln Ser Leu Ser Thr Lys Lys Wing Gly Leu 225 230 235 240 Gln Ser Tyr Ala Val Leu Val Asn Lys Glu Asn Arg Gly Thr Ser He 245 250 255 Lys Leu Trp Val Wing Phe Gly He Val Met Phe Gly Phe Tyr Phe Wing 260 265 270 Asn Thr Trp Thr Pro Lys Leu Leu Val Glu Thr Gly Met Ser Glu Gln 25 ... .-. ^, £.-¿,? , L. i. 275 280 285 Gln Gly He He Gly Gly Leu Met Leu Ser Met Gly Gly Wing Phe Gly 290 295 300 Ser Leu Leu Tyr Gly Phe Leu Thr Thr Lys Phe Ser Ser Arg Asn Thr 305 310 315 320 Leu Met Thr Phe Met Val Leu Ser Gly Leu Thr Leu He Leu Phe He 325 330 335 Ser Ser Thr Ser Val Pro Ser He Wing Phe Wing Ser Gly Val Val Val 345 345 350 • Gly Met Leu He Asn Gly Cys Val Wing Gly Leu Tyr Thr Leu Ser Pro 355 360 365 Gln Leu Tyr Ser Wing Glu Val Arg Thr Thr Gly Val Gly Wing Wing He 370 375 380 Gly Met Gly Arg Val Gly Wing He Ser Wing Pro Leu Leu Val Gly Gly 385 390 395 400 Leu Leu Asp Ser Gly Trp Ser Pro Thr Gln Leu Tyr Val Gly Val Wing 405 410 415 Val He Val He Wing Gly Wing Thr Wing Leu He Gly Met Arg Thr Gln 420 425 430 Wing Val Wing Val Glu Lys Gln Pro Glu Wing Leu Wing Thr Lys 10 435 440 445 < 210 > 603 < 211 > 813 • < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (790) < 223 > RXN00661 15 < 400 > 603 cggatgeaag agaaccgtgg tttcgctgat ttttggcgaa cccggaatta aggccccgag 60 gattacatgc ttttaaatcc tttgaaaagg ggacaagatc atg aat ect ata ata 115 Met Asn Pro He Thr 1 5 gaa tta tta gac gca here cta tgg ate ggc gga gtt ccg att ctg tgg 163 Glu Leu Leu Asp Ala Thr Leu Trp He Gly Gly Val Pro He Leu Trp 10 15 20 cgc gaa ate ate ggc aac gtt ttc gga tta ttt age gcg tgg gca gga 211 • Arg Glu He He Gly Asn Val Phe Gly Leu Phe Ser Wing Trp Wing Gly 25 30 35 atg cg cgc ate gtg tgg gca tgg ccc ate ggc ate ata ggc aac gcg 259 20 Met Arg Arg He Val Trp Wing Trp Pro He Gly He He Gly Asn Wing 40 45 50 ctg ctg ttc here gta ttt at ggc ggc ctt ttc falls act cca caa aac 307 Leu Leu Phe Thr Val Phe Met Gly Gly Leu Phe His Thr Pro Gln Asn 55 60 65 etc etc gat ggc caa gcg ggt cgc cag ate atg ttc ate ate gtc 355 Leu Asp Leu Tyr Gly Gln Wing Gly Arg Gln He Met Phe He He Val 70 75 80 85 agt ggt tat ggc tgg tac caa tgg tcg gcc gca aaa cgc cgc gca etc 403 Ser Gly Tyr Gly Trp Tyr Gln Trp Ser Ala Ala Lys Arg Arg Ala Leu 90 95 100 acc cca gaa aat gca gta gca gtg gtt ect cgc tgg gca age acc aaa 451 25 Thr Pro Glu Asn Wing Val Wing Val Val Pro Arg Trp Wing Ser Thr Lys 105 110 115 gaa cgc gcc ggc att gtg att gcg gcg gtt gtg gga here etc age ttt 499 Glu Arg Wing Gly He Val Wing Wing Val Val Gly Thr Leu Ser Phe 120 125 130 gcc tgg att ttc caa gca etc ggc tcc tgg ggg cca tgg gcc gac gcg 547 Wing Trp He Phe Gln Wing Leu Gly Ser Trp Gly Pro Trp Wing Asp Wing 135 140 145 tgg att ttc gtc ggc tca ate ctg gct acc tac gga atg gct cgc gga 595 5 Trp He Phe Val Gly Ser He Leu Wing Thr Tyr Gly Met Wing Arg Gly 150 155 160 165 tgg here gag ttc tgg ctg ate tgg ate gcc gtc gac ata gtt ggc gtt 643 Trp Thr Glu Phe Trp Leu He Trp He Wing Val Asp He Val Gly Val 170 175 180 ect cta ctt ttg act gct gcc tac tac cca tcc gcg gtg ctt tac ctg 691 Pro Leu Leu Leu Thr Wing Gly Tyr Tyr Pro Ser Wing Val Leu Tyr Leu 185 190 195 gtg tac ggt gcg ttt gtc age tgg gga ttt gtg tgg ctg cgg gtg 739 Val Tyr Gly Wing Phe Val Ser Trp Gly Phe Val Val Trp Leu Arg Val 200 205 210 caa aaa gca gac aag gct cgt gcg ctg gaa gct cag gag tet gtg here 787 Q Gln Lys Wing Asp Lys Wing Arg Wing Leu Glu Wing Gln Glu Ser Val Thr 215 220 225 gtc tgaaaagcgt ttactaaata gaa 813 Val 230 < 210 > 604 < 211 > 230 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 604 Met Asn Pro He Thr Glu Leu Leu Asp Wing Thr Leu Trp He Gly Gly 1 5 10 15 Val Pro He Leu Trp Arg Glu He He Gly Asn Val Phe Gly Leu Phe 20 25 30 Being Wing Trp Wing Gly Met Arg Arg He Val Trp Wing Trp Pro He Gly 35 40 45 He He Gly Asn Wing Leu Leu Phe Thr Val Phe Met Gly Gly Leu Phe 50 55 60 His Thr Pro Gln Asn Leu Asp Leu Tyr Gly Gln Wing Gly Arg Gln He 65 70 75 80 Met Phe He He Val Ser Gly Tyr Gly Trp Tyr Gln Trp Ser Wing Wing 85 90 95 Lys Arg Arg Wing Leu Thr Pro Glu Asn Wing Val Wing Val Val Pro Arg 100 105 110 Trp Wing Being Thr Lys Glu Arg Wing Gly He Val He Wing Wing Val Val 115 120 125 Gly Thr Leu Ser Phe Wing Trp He Phe Gln Wing Leu Gly Ser Trp Gly 130 135 140 Pro Trp Wing Asp Wing Trp He Phe Val Gly Ser He Leu Wing Thr Tyr 145 150 155 160 Gly Met Wing Arg Gly Trp Thr Glu Phe Trp Leu He Trp He Wing Val 165 170 175 Asp He Val Gly Val Pro Leu Leu Leu Thr Wing Gly Tyr Tyr Pro Ser 180 185 190 Wing Val Leu Tyr Leu Val Tyr Gly Wing Phe Val Ser Trp Gly Phe Val íl i i -a..rt JÍ. í írrí ^ .: 195 200 205 Val Trp Leu Arg Val Gln Lys Ala Asp Lys Ala Arg Ala Leu Glu Ala 210 215 220 Gln Glu Ser Val Thr Val 225 230 < 210 > 605 < 211 > 1332 < 212 > DNA • < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1309) < 223 > RXN02566 < 400 > 605 gactccggat < gatcaageag cgaaacctt1t gttüaagaaca tagctcccca t? CCtiagacaa 60 aagtccaaat; aaatctgctc aataacctaa cctaaatgtec atg falls gcc tcg tcg 115 Met His Wing Being Ser 10 1 5 ccc caa ect falls ect cag cgc acc cgt gtt etc age ggc ctg att ttc 163 Pro Gln Pro His Pro Gln Arg Thr Arg Val Leu Ser Gly Leu He Phe 10 15 20 • gcc caa ate atg gtt ggt gca tcc aat ggc gtg acg cta tcg atg gga 211 Wing Gln He Met Val Gly Wing Wing Asn Gly Val Thr Leu Ser Met Gly 25 30 35 agt ttg ctg gca gca drops ttg gcg gga gct tcg tgg gga gga tca gcc 259 Be Leu Leu Ala Ala His Leu Ala Gly Ala Be Trp Gly Gly Be Ala 40 45 50 gcc here ttg acc acg ate ggc gca gct ate ttt tcg att ccc ctt gcc 307 Wing Thr Leu Thr Thr He Gly Wing Wing He Phe Ser He Pro Leu Wing 15 55 60 65 cgc atg gtc tcc here tac gat cgc cga act tca etc age acg ggc atg 355 Arg Met Val Ser Thr Tyr Asp Arg Arg Thr Ser Leu Ser Thr Gly Met 70 75 80 85 ttg ctt ggt tgc gtg ggc gca cta cg gcg ate ggc gca gca caca ttc 403 Leu Leu Gly Cys Val Gly Ala Leu Leu Ala He Leu Gly Ala Gln Phe 90 95 100 ggc ttg ttt cca gta gta ctt ttg gca ttt ttg ttc etc gga tcc atg 451 Gly Leu Phe Pro Val Val Leu Leu Ala Phe Leu Phe Leu Gly Ser Met 105 110 115 tcg gcg gtt aac etc caa gca cgt ttc gcc gca acc gac gtg gcc agt 499 Be Ala Wing Asn Leu Gln Wing Arg Phe Wing Wing Thr Asp Val Wing Ser 20 120 125 130 gaa gaa acc cgc ggc cgc gac etc tcg ate gtt gtg tgg tcc acc acc 547 Glu Glu Thr Arg Gly Arg Asp Leu Ser He Val Val Trp Ser Thr Thr 135 140 145 ate ggc gca ate gcc gga cca aat tta ttt gaa cca age gcc cga ttc 595 He Gly Wing He Wing Gly Pro Asn Leu Phe Glu Pro Being Wing Arg Phe 150 155 160 165 age gaa acc ctg ggc etc gaa caa cat gcc ggc gca tac ctg tgt 643 Ser Glu Thr Leu Gly Leu Glu Gln His Wing Gly Wing Tyr Leu Leu Cys 170 175 180 tta ttt ggc cag etc ate gcc ate gca gtc tgg cga ttc acc etc ccc 691 Leu Phe Gly Gln Leu He Wing He Wing Val Trp Arg Phe Thr Leu Pro 25 185 190 195 ¿^^^ w ^^^^^^ i ^ ^ f ^^^ j ^^^^^^^^^ * * "aaa ggc etc aaa ccc gaa gcc acc cca aat gca cca aga gaa aag aag 739 Lys Gly Leu Lys Pro Glu Wing Thr Pro Asn Wing Pro Thr Glu Lys Lys 200 205 210 cgc etc acc ccg aaa gcc etc caa gcc ate here tcg gtt gca acc gca 787 Arg Leu Thr Pro Lys Wing Leu Gln Wing He Thr Ser Val Wing Thr Wing 215 220 225 falls ttc tcc atg gtc ggt etc atg tcc atg gcc gcc ate drops atg caa 835 His Phe Ser Met Val Gly Leu Met Ser Ala Ala Ala He His Met Gln 230 235 240 245 ggc falls ggc gcc age etc acc ate ate ggc ttc acc ate agt ttg falls Gly His Gly Ala Ser Leu Thr He He Gly Phe Thr He Ser Leu His 250 255 260 gtc gcc gga atg tac gca etc tca cca gtg ttc ggc ctg etc here gac 931 Val Ala Gly Met Tyr Ala Leu Ser Pro Val Phe Gly Leu Leu Thr Asp 265 270 275 aaa etc ggc cgc aat gtc acc ate tat tcc ggc tcc gcc atg etc gcc 979 Lys Leu Gly Arg Asn Val Thr He Tyr Ser Gly Phe Wing Met Leu Wing 280 285 290 here tcc gca gt ttt ctt ate att tgg ccc gaa cca cag tgg gcc atg 1027 Thr Be Ala Wing Phe Leu He He Trp Pro Glu Pro Gln Trp Wing Met 10 295 300 305 tie here tcc atg ate ctg ctt ggg etc ggc tgg aac tet gcc etc gtc 1075 He Thr Ser Met He Leu Leu Gly Leu Gly Trp Asn Ser Wing Leu Val 310 315 320 325 • ggt tet tca here ttg ctt gtc gac gcc acc ccc ate fall falls cgc acc 1123 Gly Ser Ser Thr Leu Leu Val Asp Ala Thr Pro He His His Arg Thr 330 335 340 tac gcc cag ggg cgc age gac cta acg atg aat ctt gcg gga gct tca 1171 Tyr Wing Gln Gly Arg Ser Asp Leu Thr Met Asn Leu Wing Gly Ala Ser 345 350 355 ggc ggg ttg ate gcc gga ccg tta att gcc atg ggc gga atg ccc ttg 1219 Gly Gly Leu He Wing Gly Pro Leu He Wing Met Gly Gly Met Pro Leu 15 360 365 370 ttg gca ggc gtc gtt ctt gt gtt gtg gcg ctt cag acg gtt ctt agt 1267 Leu Ala Gly Val Val Leu Ala Val Val Ala Leu Gln Thr Val Leu Ser 375 380 385 ttc aga acc tgt tca att gaa aag act ect gct tca tgt ttt 1309 Phe Arg Thr Arg Ser He Glu Lys Thr Pro Wing Ser Cys Phe 390 395 400 tagcctagga aittcaicgcaic gaic 1332 • < 210 > 606 < 211 > 403 < 212 > PRT 20 < 213 > Corynebacterium glutamicum < 400 > 606 Met His Wing Being Ser Pro Gln Pro His Pro Gln Arg Thr Arg Val Leu 1 5 10 15 Ser Gly Leu He Phe Wing Gln He Met Val Gly Wing Being Asn Gly Val 20 25 30 Thr Leu Ser Met Gly Ser Leu Leu Wing Ala His Leu Ala Gly Wing Ser 35 40 45 Trp Gly Gly Ser Wing Wing Thr Leu Thr Thr He Gly Wing Wing He Phe 50 55 60 Ser He Pro Leu Wing Arg Met Val Ser Thr Tyr Asp Arg Arg Thr Ser 25 65 70 75 80 ? * í Í!! 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Leu Ser Thr Gly Met Leu Leu Gly Cys Val Gly Ala Leu Leu Ala He 85 90 95 Leu Gly Ala Gln Phe Gly Leu Phe Pro Val Val Leu Leu Ala Phe Leu 100 105 110 Phe Leu Gly Ser Met Ser Ala Val Asn Leu Gln Ala Arg Phe Wing Wing 115 120 125 Thr Asp Val Wing Ser Glu Glu Thr Arg Gly Arg Asp Leu Ser He Val 130 135 140 Val Trp Ser Thr Thr He Gly Wing He Wing Gly Pro Asn Leu Phe Glu • 145 150 155 160 Pro Ser Wing Arg Phe Ser Glu Thr Leu Gly Leu Glu Gln His Wing Gly 165 170 175 Wing Tyr Leu Leu Cys Leu Phe Gly Gln Leu Wing Wing Wing Val Trp 180 185 190 Arg Phe Thr Leu Pro Lys Gly Leu Lys Pro Glu Wing Thr Pro Asn Wing 195 200 205 Pro Thr Glu Lys Lys Arg Leu Thr Pro Lys Wing Leu Gln Wing He Thr 210 215 220 Ser Val Wing Thr Wing His Phe Ser Met Val Gly Leu Met Ser Met Wing 225 230 235 240 Wing He His Met Gln Gly His Gly Ala Ser Leu Thr 10 He He Gly Phe 245 250 255 Thr He Ser Leu His Val Wing Gly Met Tyr Ala Leu Ser Pro Val Phe 260 265 270 • Gly Leu Leu Thr Asp Lys Leu Gly Arg Asn Val Thr He Tyr Ser Gly 275 280 285 Phe Wing Met Leu Wing Thr Be Wing Wing Phe Leu He He Trp Pro Glu 290 295 300 Pro Gln Trp Wing Met He Thr Ser Met He Leu Leu Gly Leu Gly Trp 305 310 315 320 Asn Ser Wing Leu Val Gly Ser Be Thr Leu Leu Val Asp Wing Thr Pro 325 330 335 15 He His His Arg Thr Tyr Wing Gln Gly Arg Ser Asp Leu Thr Met Asn 340 345 350 Leu Wing Gly Wing Gly Gly Leu Wing Wing Gly Pro Leu Wing Wing Met 355 360 365 Gly Gly Met Pro Leu Leu Wing Gly Val Val Leu Wing Val Val Wing Leu 370 375 380 Gln Thr Val Leu Ser Phe Arg Thr Arg Ser He Glu Lys Thr Pro Wing 385 390 395 400 Ser Cys Phe < 210 > 607 < 211 > 760 20 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (760) < 223 > FRXA02561 < 400 > 607 atctgctcaa taacctaacc taaagtccat gcacgcctcg tcgccccaac ctcaccctca 60 gcgcacccgt gttctcagcg gcctgatttt cgcccaaatc atg gtt ggt gca tcc 115 Met Val Gly Ala Ser 25 1 5 * £ - _ * ___,, ^^ MiafcAh aat ggc gtg acg cta tcg atg gga agt ttg ctg gca gca falls ttg gcg 163 Asn Gly Val Thr Leu Ser Met Gly Ser Leu Leu Ala Ala His Leu Ala 10 15 20 gga gct tcg tgg gga gga tca gcc gcc here ttg acc acg ate ggc gca 211 Gly Ala Ser Trp Gly Gly Be Wing Wing Thr Leu Thr Thr He Gly Wing 25 30 35 gct ate ttt tcg att ccc ctt gcc cgc atg gtc tcc here tac gat cgc 259 Wing He Phe Ser He Pro Leu Wing Arg Met Val Ser Thr Tyr Asp Arg 40 45 50 cga act tca etc age acg ggc atg ttg ctt ggt tgc gg ggc gca cta 307 Arg Thr Ser Leu Ser Thr Gly Met Leu Leu Gly Cys Val Gly Ala Leu 55 60 65 ctg gcg ate ggc gca gca caa ttc ggc ttg ttt cca gta gta ctt ttg gta 355 Leu Wing He Leu Gly Wing Gln Phe Gly Leu Phe Pro Val Val Leu Leu 70 75 80 85 gca ttt ttg ttc etc gga tcc atg tcg gcg gtt aac etc caa gca cgt 403 Wing Phe Leu Phe Leu Gly Ser Met Be Wing Val Asn Leu Gln Wing Arg 90 95 100 ttc gcc gca gcg acc acc gtg gcc agt gaa gaa acc cgc cgc gcc gac etc 451 Phe Wing Wing Thr Asp Val Wing Ser Glu Glu Thr Arg Gly Arg Asp Leu 105 110 115 tcg ate gtt gtg tgg tcc acc acc ggc gca ate gcc gga gca cca aat 499 Ser He Val Val Trp Ser Thr Thr He Gly Wing He Wing Gly Pro Asn 120 125 130 tta ttt gac cca age gcc cga ttc age gaa acc ctg ggc etc gaa caa 547 Leu Phe Glu Pro Be Wing Arg Phe Ser Glu Thr Leu Gly Leu Glu Gln 135 140 145 cat gcc ggc gca tac ctg ctg tgt tta ttt ggc cag etc ate gcc ate 595 His Wing Gly Wing Tyr Leu Leu Cys Leu Phe Gly Gln Leu He Ala He 150 155 160 165 gca gtc tgg cga ttc acc ccc aaa aaa ggc etc aaa ccc gaa gcc acc 643 Wing Val Trp Arg Phe Thr Leu Pro Lys Gly Leu Lys Pro Glu Wing Thr 170 175 180 cca aat gca cca here gaa aag aag cgc etc acc ccg aaa gcc etc caa 691 Pro Asn Wing Pro Thr Glu Lys Lys Arg Leu Thr Pro Lys Wing Leu Gln 185 190 195 gcc tet here tcg gtt gca acc gca falls ttc tcc atg gtc ggt etc atg 739 Wing He Thr Ser Val Ala Thr Ala His Phe Ser Met Val Gly Leu Met 200 205 210 tcc atg gcc gcc ate drops atg 760 Ser Met Ala Ala He His Met 215 220 <; 210 > 608 < 211 > 220 < 212 > PRT < 213 > Corynebact: erium glutamicum < 400 > 608 Met Val Gly Wing Being Asn Gly Val Thr Leu Ser Met Gly Being Leu Leu 1 5 10 15 Wing Wing His Leu Wing Gly Wing Being Trp Gly Gly Wing Wing Thr Leu 20 25 30 Thr Thr He Gly Wing Wing He Phe Ser He Pro Leu Ala Arg Met Val 35 40 45 Ser Thr Tyr Asp Arg Arg Thr Ser Leu Ser Thr Gly Met Leu Leu Gly 50 55 60 Cys Val Gly Ala Leu Leu Ala He Leu Gly Ala Gln Phe Gly Leu Phe 65 70 75 80 Pro Val Val Leu Leu Ala Phe Leu Phe Leu Gly Ser Met Ser Ala Val 85 90 95 Asn Leu Gln Ala Arg Phe Ala Ala Thr Asp Val Wing Ser Glu Glu Thr 100 105 110 Arg Gly Arg Asp Leu Ser He Val Val Trp Ser Thr Thr He Gly Wing 115 120 125 He Wing Gly Pro Asn Leu Phe Glu Pro Ser Wing Arg Phe Ser Glu Thr • 130 135 140 Leu Gly Leu Glu Gln His Wing Gly Wing Tyr Leu Leu Cys Leu Phe Gly 145 150 155 160 Gln Leu He Wing Wing Val Trp Arg Phe Thr Leu Pro Lys Gly Leu 165 170 175 Lys Pro Glu Wing Thr Pro Asn Wing Pro Thr Glu Lys Lys Arg Leu Thr 180 185 190 Pro Lys Wing Leu Gln Wing He Thr Ser Val Wing Thr Wing His Phe Ser 195 200 205 Met Val Gly Leu Met Ser Met Wing Ala He His Met 210 215 220 10 < 210 > 609 < 211 > 461 < 212 > DNA • < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (438) < 223 > FRXA02566 < 400 > 609 15 ate agt ttg falls gtc gcc gg atg tac gca etc tca cca gtg ttc ggc 48 He Ser Leu His Val Ala Gly Met Tyr Ala Leu Ser Pro Val Phe Gly 1 5 10 15 ctg etc here gac aaa etc ggc cgc aat gtc acc ate tat tcc ggc ttc 96 Leu Leu Thr Asp Lys Leu Gly Arg Asn Val Thr He Tyr Ser Gly Phe 20 25 30 gcc atg etc gcc here tcc gca gt ttt ctt ate att tgg ccc gaa cca 144 Wing Met Leu Ala Thr Ser Wing Ala Phe Leu He He Trp Pro Glu Pro 35 40 45 • cag tgg gcc atg ate here tcc atg ate ctg ctt ggg etc ggc tgg aac 192 Gln Trp Wing Met He Thr Ser Met He Leu Leu Gly Leu Gly Trp Asn 50 55 60 20 tet gcc etc gtc ggt tet here ttg ctt gtc gac gcc acc ccc ate 240 Be Ala Leu Val Gly Be Ser Thr Leu Leu Val Asp Ala Thr Pro He 65 70 75 80 fall falls cgc acc tac gcc cag ggg cgc age gac cta acg atg aat ctt 288 His His Arg Thr Tyr Wing Gln Gly Arg Ser Asp Leu Thr Met Asn Leu 85 90 95 gcg gga gct tca ggc ggg ttg ate gcc gga ccg tta att gcc atg ggc 336 Wing Gly Wing Being Gly Gly Leu Wing Wing Gly Pro Leu He Ala Met Gly 100 105 110 gga atg ccc ttg ttg gca ggc gtc gtt ctt gca gtt gtg gcg ctt caa 384 Gly Met Pro Leu Leu Wing Gly Val Val Leu Wing Val Val Wing Ala Leu Gln 115 120 125 25 acg gtg ctt agt ttc aga acc cgt tca att gaa aag act ect gct tca 432 gg¡HHg¡g¡ ttg¡¡ ^^ jj: * lrrÍL & Ári¿ jLr ák *? ^ Thr Val Leu Ser Phe Arg Thr Arg Ser He Glu Lys Thr Pro Wing Ser 130 135 140 tgt ttt tagcctagga attcacgcac gac 461 Cys Phe 145 < 210 > 610 < 211 > 146 < 212 > PRT • < 213 > Corynebacterium glutamicum < 400 > 610 He Be Ser Leu His Val Wing Gly Met Tyr Wing Leu Ser Pro Val Phe Gly 1 5 10 15 Leu Leu Thr Asp Lys Leu Gly Arg Asn Val Thr He Tyr Ser Gly Phe 20 25 30 Wing Met Leu Wing Thr Ser Wing Wing Phe Leu He He Trp Pro Glu Pro 35 40 45 Gln Trp Wing Met He Thr Ser Met He Leu Leu Gly Leu Gly Trp Asn 50 55 60 Ser Wing Leu Val Gly Ser Ser Thr Leu Leu Val 10 Asp Wing Thr Pro He 65 70 75 80 His His Arg Thr Tyr Wing Gln Gly Arg Ser Asp Leu Thr Met Asn Leu 85 90 95 • Wing Gly Wing Gly Gly Leu Wing Wing Pro Leu He Wing Met Gly 100 105 110 Gly Met Pro Leu Leu Wing Gly Val Val Leu Wing Val Val Ala Leu Gln 115 120 125 Thr Val Leu Ser Phe Arg Thr Arg Ser He Glu Lys Thr Pro Wing Ser 130 135 140 Cys Phe 145 15 < 210 > 611 < 211 > 1527 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1504; • < 223 > RXA00051 < 400 > 611 cagtaaaagt gcaccgacac taagaatcct tatccttcag agtaaggtga tctgcgtcaa 60 20 aaaatgtccg ctattcaccc gaaacgaggt cagcatctcg atg aat gcc tct ect 115 Met Asn Wing Pro Pro 1 5 gcc cca acc cga tet ttt aaa gga ttg cgg gct cga fall att fall ttc 163 Wing Pro Thr Arg Ser Phe Lys Gly Leu Arg Wing Arg His He His Phe 10 15 20 ate gcg ctg ggt tcc gcg ate ggc acc ggc ttg ttc tac ggt tct gct 211 He Ala Leu Gly Ser Ala He Gly Thr Gly Leu Phe Tyr Gly Ser Ala 25 30 35 ggc gca ate caa gca gct ggt cca tet gta etc ttg gtc tac ctt etc 259 Gly Ala He Gln Ala Ala Gly Pro Ser Val Leu Leu Val Tyr Leu Leu 25 40 45 50 ÍLLÍ.Á > rlr4Í .Í ... Jjj. t ^. J ggt ggc gcc gtc gtc gtg tac ttc atg ctg cgc gca etc ggc gag atg gct 307 Gly Gly Wing Val Val Tyr Phe Met Leu Arg Ala Leu Gly Glu Met Wing 55 60 65 gtg cat falls cca gtc cgt ggt tcc ttc gcg gtc tac acc cgc gca falls 355 Val His His Pro Val Arg Gly Ser Phe Ala Val Tyr Thr Arg Ala His 70 75 80 85 ctt ggc gga tgg gca ggc tac ate acc ggc tgg atg ttc gcg ttt gag 403 Leu Gly Gly Trp Wing Gly Tyr He Thr Gly Trp Met Phe Wing Phe Glu 90 95 100 • atg etc ate gtc tgc ctg gct gac etc here gcc ate ggc ate tat atg 451 Met Leu He Val Cys Leu Ala Asp Leu Thr Ala He Gly He Tyr Met 105 110 115 aac ttc tgg ttc ccc ggc acc cca caa tgg act tgg gtg gta gcc acc 499 Asn Phe Trp Phe Pro Gly Thr Pro Gln Trp Thr Trp Val Val Wing Thr 120 125 130 ctt ctt att gtc ggt ggc gca aac etc gca tca gtg cgt tgg ttc ggt 547 Leu Leu He Val Gly Gly Wing Asn Leu Wing Ser Val Arg Trp Phe Gly 135 140 145 gag etc gag ttc ate ttc ate att aag gtc acc gca gtt gtc gcc 595 Glu Leu Glu Phe He Phe Thr He He Lys Val Thr Ala Va l Val Wing 10 150 155 160 165 atg ate gtc ggc ggc gca gcc ate etc gca ttc ggt etc ggc gcc aac 643 Met He Val Gly Gly Wing Ala He Leu Wing Phe Gly Leu Gly Wing Asn 170 175 180 • gct gaa gtt gcc ggc gta tcc aac etc tgg gag drops ggc gga ttc ttc 691 Wing Glu Val Wing Gly Val Being Asn Leu Trp Glu His Gly Gly Phe Phe 185 190 195 ccc aac ggt gtt gaa ggc atg ate gca gcc ttc ate ctt gtt etc ttc 739 Pro Asn Gly Val Glu Gly Met He Wing Wing Phe He Leu Val Leu Phe 200 205 210 gca ttc ggt ggc acc gaa ate ate ggt gtt gca ggc tet gaa gct gaa 787 Wing Phe Gly Gly Thr Glu He He Gly Val Wing Gly Ser Glu Wing Glu 15 215 220 225 gat ect gag aag tcc ate ccc aag gct gtt aat act gtc cca gta cgc 835 Asp Pro Glu Lys Ser He Pro Lys Ala Val Asn Thr Val Pro Val Arg 230 235 240 245 ate etc etc ttc tat gtg ggt gcc ate ctg gtg ate ctt gcc ctt aat 883 He Leu Leu Phe Tyr Val Gly Ala He Leu Val He Leu Ala Leu Asn 250 255 260 ect tgg ect tcc ate acc ggc gaa gaa tcc cca ttc gtc cag ate ttc 931 Pro Trp Pro Ser H e Thr Gly Glu Glu Pro Pro Phe Val Gln He Phe • 265 270 275 gac acc etc. ggc gtc aac tgg gct gct gct gct etc gc aac gcc gtc gtc 979 Asp Thr Leu Gly Val Asn Trp Wing Wing Gly Leu Asu Wing Val Val 20 280 285 290 ate acc gct gc ctg tet gcc ate aac gct gac etc tcc ggc gct gcc 1027 He Thr Ala Ala Leu Ser Ala He Asn Ala Asp Leu Phe Gly Ala Gly 295 300 305 cgc gtt etc act ggt ctt gcg aag gaa aac etc gca cca aag gcc atg 1075 Arg Val Leu Thr Gly Leu Wing Lys Glu Asn Leu Wing Pro Lys Wing Met 310 315 320 325 ggc aag ate gcc aag aac ggc gtt cca gtc atg acc acc acc atg 1123 Gly Lys He Ala Lys Asn Gly Val Pro Val Met Thr Thr Thr He Met 330 335 340 ate ate gtc ttg ate gtg gga gta gta ate etc aac gca gtg ctt ccc gag 1171 He He Val Leu He Val Gly Val He Leu Asn Ala Val Leu Pro Glu 25 345 350 355 cgc gtc ttc gag ate gtc gct tcc cta gca acc ttc gcc here gtt tac 1219 Arg Val Phe Glu He Val Wing Ser Leu Wing Thr Phe Wing Thr Val Tyr 360 365 370 gtc tgg ctg atg ate ctg etc gca cag gtg gga tcc cgc cga aac atg 1267 Val Trp Leu Met He Leu Leu Wing Gln Val Gly Ser Arg Arg Asn Met 375 380 385 ect gcc gac gtc aag tcc ctg aag ttc ect gtc ccc ttc tac ccc 1315 Pro Wing Asp Glu Val Lys Ser Leu Lys Phe Pro Val Pro Phe Tyr Pro 390 395 400 405 ^ ttc gga caa tac tc gcg ate cta ttt ate gcc ttc acc ttc ggc ate 1363 Phe Gly Gln Tyr Phe Wing He Leu Phe He Wing Phe Thr Phe Gly He 410 415 420 atg gtc tgg tac gac aac tac falls ctg cca etc gcc gtc ggc gtt gga 1411 Met Val Trp Tyr Asp Asn Tyr His Leu Pro Leu Wing Val Gly Val Gly 425 430 435 ttc ctt gtc ctg atg here ate ctt tac tac gcc here ggc cga cca aag 1459 Phe Leu Val Leu Met Thr He Leu Tyr Tyr Wing Thr Gly Arg Pro Lys 440 445 450 gcg ate gct ccg ate gat tat gaa gag cta gat ccg cga cgc gat 1504 Ala He Ala Pro He Asp Tyr Glu Glu Leu Asp Pro Arg Arg Asp 10 455 460 465 taal: cta < gac tegeaegaaa aag 1527 < 210 > 612 < 211 > 468 • < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 612 Met Asn Wing Pro Pro Wing Pro Thr Arg Ser Phe Lys Gly Leu Arg Wing 1 5 10 15 Arg His He His Phe He Wing Leu Gly Wing He Wing Gly Thr Gly Leu 15 20 25 30 Phe Tyr Gly Wing Wing Gly Wing He Gln Ala Ala Gly Pro Ser Val Leu 35 40 45 Leu Val Tyr Leu Leu Gly Gly Ala Val Val Tyr Phe Met Leu Arg Ala 50 55 60 Leu Gly Glu Met Ala Val His His Pro Val Arg Gly Ser Phe Ala Val 65 70 75 80 Tyr Thr Arg Ala His Leu Gly Gly Trp Wing Gly Tyr He Thr Gly Trp 85 90 95 Met Phe Wing Phe Glu Met Leu He Val Cys Leu Wing Asp Leu Thr Wing 100 105 110 He Gly He Tyr Met Asn Phe Trp Phe Pro Gly Thr Pro Gln Trp Thr 20 115 120 125 Trp Val Val Wing Thr Leu Leu He Val Gly Gly Wing Asn Leu Wing Ser 130 135 140 Val Arg Trp Phe Gly Glu Leu Glu Phe He Phe Thr He He Lys Val 145 150 155 160 Thr Ala Val Val Ala Met He Val Gly Gly Ala Ala He Leu Ala Phe 165 170 175 Gly Leu Gly Ala Asn Ala Glu Val Ala Gly Val Ser Asn Leu Trp Glu 180 185 190 His Gly Gly Phe Pro Asn Gly Val Glu Gly Met He Ala Ala Phe 195 200 205 He Leu Val Leu Phe Wing Phe Gly Gly Thr Glu He He Gly Val Wing 25 210 215 220 i 4A.?.4Í4? .. i *? l »á ~ l * ?. i .- ^. j.'a. > .1,?., Gly Ser Glu Wing Glu Asp Pro Glu Lys Ser He Pro Lys Wing Val Asn 225 230 235 240 Thr Val Pro Val Arg He Leu Leu Phe Tyr Val Gly Ala He Leu Val 245 250 255 He Leu Ala Leu Asn Pro Trp Pro Ser He Thr Gly Glu Glu Ser Pro 260 265 270 Phe Val Gln He Phe Asp Thr Leu Gly Val Asn Trp Wing Wing Gly Leu 275 280 285 Leu Asn Wing Val Val He Thr Wing Wing Leu Ser Wing He Asn Wing Asp • 290 295 300 Leu Phe Gly Wing Gly Arg Val Leu Thr Gly Leu Wing Lys Glu Asn Leu 305 310 315 320 Wing Pro Lys Wing Met Gly Lys He Wing Lys Asn Gly Val Pro Val Met 325 330 335 Thr Thr Thr He Met He He Val Leu He Val Gly Val He Leu Asn 340 345 350 Wing Val Leu Pro Glu Arg Val Phe Glu He Val Wing Ser Leu Wing Thr 355 360 365 Phe Wing Thr Val Tyr Val Trp Leu Met He Leu Leu Wing Gln Val Gly 370 375 380 10 Ser Arg Arg Asn Met Pro Wing Asp Glu Val Lys Ser Leu Lys Phe Pro 385 390 395 400 Val Pro Phe Tyr Pro Phe Gly Gln Tyr Phe Wing He Leu Phe He Wing 405 410 415 • Phe Thr Phe Gly He Met Val Trp Tyr Asp Asn Tyr His Leu Pro Leu 420 425 430 Wing Val Gly Val Gly Phe Leu Val Leu Met Thr He Leu Tyr Tyr Wing 435 440 445 Thr Gly Arg Pro Lys Ala He Wing Pro He Asp Tyr Glu Glu Leu Asp 450 455 460 Pro Arg Arg Asp 465 15 < 210 > 613 < 211 > 1578 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1555) < 223 > RXA0H72 < 400 > 613 20 taaattttte tagactaccc agattaagtg agattettte gtgtcttcga caacttcgac 60 aacttcggcc acccgacaag agccgttgag cccgacgggt gtg ctt gcc tcg ttt 115 Val Leu Ala Ser Phe 1 5 agg ttc gcg ttt agt age ccg cgg agg ttt cgc acc gag gtt tta gct 163 Arg Phe Ala Phe Ser Ser Pro Arg Arg Phe Arg Thr Glu Val Leu Wing 10 15 20 ggc etc gtg gtg gcg etc gcg ctg att ccg gag tcg att gcg ttt tcc 211 Gly Leu Val Val Ala Leu Ala Leu He Pro Glu Ser He Wing Phe Ser 25 30 35 gta tta gct ggc gtg gat ect aag atg ggt ctt ttt gcg tcg tgc acc 259 Val Leu Wing Gly Val Asp Pro Lys Met Gly Leu Phe Wing Ser Cys Thr 25 40 45 50 IiÍ.-i .á. rJ. ?: Í. rr. 1. J LJ atg gca atg acc att gcg ctt here ggt gga cgc ect gcg atg att tcc 307 Met Ala Met Thr He Ala Leu Thr Gly Gly Arg Pro Ala Met He Ser 55 60 65 gcg gcg here ggc gct gtg gcg ctg gtg att gca ccg gtg gtt cgg gat 355 Wing Wing Thr Gly Wing Val Wing Leu Val He Wing Pro Val Val Arg Asp 70 75 80 85 cat ggc gtg gaa tat ttc ctg gcc acg gta att ttg gcg ggc att att 403 His Gly Val Glu Tyr Phe Leu Wing Thr Val He Leu Wing Gly He He 90 95 100 cag att gcg ttg tcg ttg ctg ggt gta gcc aag ctg atg cgg ttc att 451 Gln He Ala Leu Ser Leu Leu Gly Val Ala Lys Leu Met Arg Phe He 105 110 115 ccg cgt tcc gtt atg etc gga ttt gtt aat gcg ctg gcg tgc ttg gtg 499 Pro Arg Ser Val Met Leu Gly Phe Val Asn Ala Leu Ala Cys Leu Val 120 125 130 ttt ttt gcg cag ctg ccg falls ctg ate gat gtt ccg tgg atg gtg tat 547 Phe Phe Wing Gln Leu Pro His Leu He Asp Val Pro Trp Met Val Tyr 135 140 145 ccg ctg ctg gcg ctg ggt att ggc ate atg ctg ttt cgg aag ctg 595 Pro Leu Phe Ala Leu Gly He Gly He Met Leu Phe Trp Pro Lys Leu 150 155 160 165 acc tcg gtg att ccg gct ccg ctg att gtt ate gtg gcc ttg act gcg 643 Thr Ser Val He Pro Wing Pro Leu He Val He Val Wing Leu Thr Wing 170 175 180 ate gtg tgg gtt ttc gga ate aac att cca aac gtc tet gac cag ggc 691 He Val Trp Val Phe Gly He Asn He Pro Asn Val Ser Asp Gln Gly 185 190 195 gaa etc ccc tet tcc cta cca gaa ttc etc att ccc aac gtt ccg ctt 739 Glu Leu Pro Ser Ser Leu Pro Glu Phe Leu Pro Pro Asn Val Pro Leu 200 205 210 act ctt gag act cta aaa att att ggg ccg tat gcg ctt gga atg tcg 787 Thr Leu Glu Thr Leu Lys He He Gly Pro Tyr Ala Leu Gly Met Ser 215 220 225 ctt gtt ggg ttg atg gaa tcg ctg ctg acc gcc aag ctg gtc gat gat 835 Leu Val Gly Leu Met Glu Ser Leu Leu Thr Ala Lys Leu Val Asp Asp 230 235 240 245 att acg gag gtt falls tcc aat aaa tcc cgc gaa gct gca ggt cag ggc 883 He Thr Glu Val His Ser Asn Lys Ser Arg Glu Wing Wing Gly Gln Gly 250 255 260 ate gca aac att ate gcg ttt gt ggc atg ggt ggc tgc gcg 931 He Ala Asn He He Thr Ala Phe Leu Gly Gly Met Gly Gly Cys Wing 265 270 275 atg ate ggc cag acc atg ate aac gtg aaa aac tca gga gcc cgc act 979 Met He Gly Gln Thr Met He Asn Val Lys Asn Ser Gly Ala Arg Thr 280 285 290 cgc cta tcc acc ttc tcg gcc tgc ggc ttc ctg ctg etc ctg gtg gtt 1027 Arg Leu Ser Thr Phe Leu Wing Gly Gly Phe Leu Leu Leu Val Valu 295 300 305 ttg ctg ggc gat gtc gtg ggc aaa ate ccc atg gcg gcg etc gtg gca 1075 Leu Leu Gly Asp Val Val Gly Lys He Pro Met Ala Ala Leu Val Ala 310 315 320 325 gtc atg att ate gtc tcc ate gac acc gcc gac tgg cat tcg ctg aac 1123 Val Met He He Val Ser He Asp Thr Wing Asp Trp His Ser Leu Asn 330 335 340 ccg cgc acc etc aaa ttc atg ccg ctg agt gaa acg ate gtc atg ttt 1171 Pro Arg Thr Leu Lys Phe Met Pro Leu Ser Glu Thr He Val Met Phe 345 350 355 ata acg ate ate gcg acc gtc acc gtc acc gga aac ctg gcg ate ggc gtc 1219 He Thr He He Wing Thr Leu Val Thr Gly Asn Leu Wing He Gly Val 360 365 370 ate etc gga gtg etc acc gcc atg gtc atg ttt gct cgc cgc gtg gcc 1267 He Leu Gly Val Leu Thr Wing Met Val Met Phe Wing Arg Arg Val Wing 375 380 385 falls etc gtg tet gtg gag cgc acc acc gac aac aac aac ate age acc tat 1315 His Leu Val Ser Val Glu Arg Thr Thr Asp Asn Asn He Ser Thr Thyr 390 395 400 405 • acc gtc aag ggc cag cta ttt tgg gcg tcc tcg aac gat atg gtg tac 1363 Thr Val Lys Gly Gln Leu Phe Trp Ala Being As Asp Met Val Tyr 410 415 420 tcc tcc gac tac tcc gac gcc gag cag ate ate ate gat etc. acc 1411 Ser Phe Asp Tyr Ser Asp Glu Ala Glu Gln He He He Asp Leu Thr 425 430 435 gcc gca gaa ate tgg gac gcc tcc acg gta gcc acg ctg gac age ate 1459 Wing Wing Glu He Trp Asp Wing Ser Thr Val Wing Thr Leu Asp Ser He 440 445 450 tetting falls aaa tac gcc gcg cgc ggc aag age gtg gag ate ate ggg etc 1507 He His Lys Tyr Wing Wing Arg Gly Lys Ser Val Glu He He Gly Leu 10 455 460 465 gac ggc ccc age cgc gat agg ctt gag cgc cta tca ggc aag ctg ggc 1555 Asp Gly Pro Ser Arg Asp Arg Leu Glu Arg Leu Ser Gly Lys Leu Gly 470 475 480 485 • taaaaatttg cttatcgacg cgc 1578 < 210 >; 614 < 211 > 485 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 614 15 Val Leu Wing Being Phe Arg Phe Wing Phe Ser Being Pro Arg Arg Phe Arg 1 5 10 15 Thr Glu Val Leu Wing Gly Leu Val Val Wing Leu Wing Leu He Pro Glu 20 25 30 Ser He Wing Phe Ser Val Leu Wing Gly Val Asp Pro Lys Met Gly Leu 35 40 45 Phe Wing Cys Thr Met Wing Met Thr He Wing Leu Thr Gly Gly Arg 50 55 60 Pro Wing Met He Wing Wing Wing Thr Gly Wing Val Wing Leu Val Wing Wing • 65 70 75 80 Pro Val Val Arg Asp His Gly Val Glu Tyr Phe Leu Ala Thr Val He 85 90 95 20 Leu Ala Gly He He Gln He Ala Leu Ser Leu Leu Gly Val Ala Lys 100 105 110 Leu Met Arg Phe He Pro Arg Ser Val Met Leu Gly Phe Val Asn Wing 115 120 125 Leu Wing Cys Leu Val Phe Phe Wing Gln Leu Pro His Leu He Asp Val 130 135 140 Pro Trp Met Val Tyr Pro Leu Phe Wing Leu Gly He Gly He Met Leu 145 150 155 160 Phe Trp Pro Lys Leu Thr Ser Val He Pro Pro Wing Leu He Val He 165 170 175 Val Wing Leu Thr Wing He Val Val Val Phe Gly He As As He As 180 180 190 Val Val As As Gln Glu Le Pro Pro Ser Leu Pro Glu Phe Leu He 195 200 205 Pro Asn Val Pro Leu Thr Leu Glu Thr Leu Lys He He Gly Pro Tyr 210 215 220 Wing Leu Gly Met Ser Leu Val Gly Leu Met Glu Ser Leu Leu Thr Wing 225 230 235 240 Lys Leu Val Asp Asp He Thr Glu Val His Ser Asn Lys Ser Arg Glu 245 250 255 Ala Ala Gly Gln Gly He Ala Asn He He Thr Ala Phe Leu Gly Gly 260 265 270 ^ 1 ^ Met Gly Gly Cys Ala Met He Gly Gln Thr Met He Asn Val Lys Asn 275 280 285 Ser Gly Wing Arg Thr Arg Leu Ser Thr Phe Leu Wing Gly Gly Phe Leu 290 295 300 Leu Leu Leu Val Leu Leu Gly Asp Val Val Gly Lys He Pro Met 305 310 315 320 Wing Wing Leu Val Wing Val Met He He Val Ser He Asp Thr Wing Asp 325 330 335 Trp His Ser Leu Asn Pro Arg Thr Leu Lys Phe Met Pro Leu Ser Glu 340 345 350 Thr He Val Met Phe He Thr He He Wing Thr Leu Val Thr Gly Asn 10 355 360 365 Leu Wing He Gly Val He Leu Gly Val Leu Thr Wing Met Val Met Phe 370 375 380 Wing Arg Arg Val Wing His Leu Val Ser Val Glu Arg Thr Thr Asp Asn 385 390 395 400 Asn He Ser Thr Thr Thyr Val Lys Gly Gln Leu Phe Trp Wing Ser 405 410 415 Asn Asp Met Val Tyr Ser Phe Asp Tyr Ser Asp Glu Wing Glu Gln He 420 425 430 He He Asp Leu Thr Wing Wing Glu He Trp Asp Wing Ser Thr Val Wing 435 440 445 Thr Leu Asp Ser He He His Lys Tyr Wing Wing Arg Gly Lys Ser Val 15 450 455 460 Glu He He Gly Leu Asp Gly Pro Ser Arg Asp Arg Leu Glu Arg Leu 465 470 475 480 Ser Gly Lys Leu Gly 485 < 210 > 615 < 211 > 1818 < 212 > DNA • < 213 > Corynebacterium glutamicum < 220 > 20 < 221 > CDS < 222 > (101) .. (1795) < 223 > RXA02128 < 400 > 615 tattagcaaa acttcttaaa gagettttt gtgcctttat cegagtatet ttaaaagcat 60 gagtattaag tgggcgcgct ttgtaccggg gataacegeg atg cgg ggc tat caa 115 Met Arg Gly Tyr Gln 1 5 cga tcc tgg ttg aag ggt gat gtc ate gcg ggt ata acc gtg gcc gcg 163 Arg Ser Trp Leu Lys Gly Asp Val He Wing Gly He Thr Val Wing Wing 10 15 20 25 tac ttg gtt cca caa gtc atg gct tat gcc gtc att gcg ggg ctg cca 211 t? L? , M.rí ..? , Tyr Leu Val Pro Gln Val Met Wing Ala Tyr Wing Val He Wing Gly Leu Pro 25 30 gc gtt gtt gt gt gt gt gt gt gt ctg gt cg atg gc g ctg gt gtg Leu Tyr Phe 40 45 50 ttc ttg ggc acg tet cga aat etc tcg gtt ggt ect gaa tca acc acc 307 Phe Leu Gly Thr Ser Arg Asn Leu Ser Val Gly Pro Glu Ser Thr Thr 55 60 65 5 gct ctg atg acg gct gca ggt gtg gga gct tta gtc ggg gca gct ggc 355 Ala Leu Met Thr Ala Ala Gly Val Gly Ala Leu Val Gly Ala Ala Gly 70 75 80 85 ggg ect gaa cga tac gca gta gaa gcg gca cta ttg gct att gca gtg 403 Gly Pro Glu Arg Tyr Ala Glu Val Ala Ala Ala Leu Leu Ala He Ala Val 90 95 100 ggc att gta tgc gct gtt ggt ttt att ggc cga ttg gga ttt ctt acc 451 Gly He Val Cys Wing Val Gly Phe He Gly Arg Leu Gly Phe Leu Thr 105 110 115 agg ctg ttg tet cga ccg gtg etc gtt gga tat ttg ate ggt att gca 499 Arg Leu Leu Ser Arg Pro Val Leu Val Gly Tyr Leu He Gly He Ala 120 125 130 JQ gtc ttg atg ate gtc agt cag ctg aka aaa gtc acc ag gtg aat gtg 547 Val Leu Met He Val Ser Gln Leu Ser Lys Val Thr Gln Val Asn Val 135 140 145 gag age ggt cag acg tgg cag gaa ata ata tcg ttt ate aaa gta gct 595 • Glu Ser Gly Gln Thr Trp Gln Glu He He Ser Phe He Lys Val Ala 150 155 160 165 ggc cag gca cat att ect here gtg att ttg gca gtc gtg ttg age 643 Gly Gln Ala His He Pro Thr Val He Leu Ala Val Val Val Leu Ser 170 175 180 ttg ctg tat ctg gca aat tgg ttg acg ect aaa ttt ccc age here etc 691 Leu Leu Tyr Leu Ala Asn Trp Leu Thr Pro Lys Phe Pro Ser Thr Leu 185 190 195 15 atg gtt ctt ctg ctt tcg gca gcc gcg gtg ggg ttt ttt cat ctg gat 739 Met Val Leu Leu Leu Ser Ala Ala Ala Val Gly Phe Phe His Leu Asp 200 205 210 agg ttt ggt ctt gag gtc att ggt gag gtg ccc cgt ggc ctg ect caa 787 Arg Phe Gly Leu Glu Val He Gly Glu Val Pro Arg Gly Leu Pro Gln 215 220 225 cca agt att ccc tcg att ggc gat cta gag ate tgg tcg ttg tcg ccc 835 Pro Ser He Pro Ser He Gly Asp Leu Glu He Trp Ser Leu Leu Pro 230 235 240 245 • tat gcc gtg ggt att gcc ate gtt ggt ttt tca gac aat gtg ttg act 883 Tyr Wing Val Gly He Wing He Val Gly Phe Ser Asp Asn Val Leu Thr 250 255 260 20 gct cgt gca ttc gcg tcg gga aaa gat gag gtg att gat tcc aac cag 931 Ala Arg Ala Phe Ala Ser Gly Lys Asp Glu Val He Asp Ser Asn Gln 265 270 275 gag ctg etc gca ctg gga acc gca aac ctg gcg aat ggg ttc ttc cag 979 Glu Leu Leu Wing Leu Gly Thr Wing Asn Leu Wing Asn Gly Phe Phe Gl 280 285 290 gga ttt ect gtg tca tcg agt ggc tcc cga act gtt ctt gga gac acg 1027 Gly Phe Pro Val Ser Ser Gly Be Arg Thr Val Leu Gly Asp Thr 295 300 305 gca ggt gct cgc act cag gtg cat tca ctt gtc gtg gtg gcg ctg gtg 1075 Wing Gly Ala Arg Thr Gln Val His Ser Leu Val Val Val Ala Leu Val 310 315 320 325 25 ate atg gtg ctg ttg ttt gct gctt ect gtg etc gag tet ttc cca gat 1123 He Met Val Leu Leu Phe Wing Gly Pro Val Leu Glu Ser Phe Pro Asp 330 335 340 gcg gca ctt ggc gcc tta gtt att tat gca gca acg cag ttg att gat 1171 Ala Ala Leu Gly Ala Leu Val He Tyr Ala Ala Thr Gln Leu He Asp 345 350 355 ate gca gag ate aaa agg ate gca cgt tcc cgc aag age gag ttg gtc 1219 He Wing Glu He Lys Arg He Wing Arg Phe Arg Lys Ser Glu Leu Val 360 365 370 tie here gcg gct act gct gca tcc gtt gtg gct tet ggc gtg etc gcg gtg 1267 He Thr Wing Wing Thr Wing Wing Val Val Wing Ser Gly Val Leu Wing 375 380 385 ggg ate ggc gtt gcg gtt acg ttg tcc ate ttg gat etc. ate aga cgt 1315 Gly He Gly Val Wing Val Thr Leu Ser He Leu Asp Leu He Arg Arg 390 395 400 405 att acc cga ect tat gcc gat gtc cta gga tat acg ccg ggc atg gct 1363 He Thr Arg Pro Tyr Wing Asp Val Leu Gly Tyr Thr Pro Gly Met Wing 410 415 420 gga atg falls age ttg gag gat tat ect gag tcg here gca gtc gaa ggg 1411 Gly Met His Ser Leu Glu Asp Tyr Pro Glu Ser Thr Wing Val Glu Gly 425 430 435 10 etc gtg gtt ttt aga tac gat tcc cca ctg tt ttc gcc aac gct gat 1459 Leu Val Val Phe Arg Tyr Asp Ser Pro Leu Phe Phe Wing Asn Wing Asp 440 445 450 gat ttt tcc aaa cgt gcc ate gaa gcc gtt gat gaa gca act caa ccc 1507 • Asp Phe Ser Lys Arg Wing He Glu Wing Val Asp Glu Wing Thr Gln Pro 455 460 465 gtg cat tgg ttt tta ctg aat gct gaa gcg aat acg gaa gtt gat etc 1555 Val His Trp Phe Leu Leu Asn Wing Glu Wing Asn Thr Glu Val Asp Leu 470 475 480 485 acg gcc gtc gat gcc atg gaa gca ctt cgc aaa acc ctg gag gag cgg 1603 Thr Ala Val Asp Ala Met Glu Ala Leu Arg Lys Thr Leu Glu Glu Arg 490 495 500 15 ggt ate cga ttt gcg atg gcc cgg gtg aag caa gat cta cgc cga age 1651 Gly He Arg Phe Ala Ala Ala Arg Val Lys Gln Asp Leu Arg Arg Ser 505 510 515 etc gag ect gc gt gt ttc att gaa ct gtg ggg gag gag tac att ttc 1699 Leu Glu Pro Wing Gly Phe He Glu Ser Val Gly Glu Glu Tyr He Phe 520 525 530 gcc here etc ccc act gca gtc aag ggg tat tcc gtg gag ttt cgc gat 1747 Wing Thr Leu Pro Thr Wing Val Lys Gly Tyr Ser Val Glu Phe Arg Asp 535 540 545 • cgt ttt gga aac tat cca gaa ggc gtt ccg aaa gaa att ttg gaa ctt 1795 Arg Phe Gly Asn Tyr Pro Glu Gly Val Pro Lys Glu He Leu Glu Leu 550 555 560 565 20 taagctgcct ggttggcgga ctt 1818 < 210 > 616 < 211 > 565 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 616 Met Arg Gly Tyr Gln Arg Ser Trp Leu Lys Gly Asp Val He Wing Gly 1 5 10 15 He Thr Val Wing Wing Tyr Leu Val Pro Gln Val Met Wing Wing Tyr Wing 20 25 30 25 He Wing Wing Gly Leu Pro Wing Val Val Gly Leu Trp Gly Val Leu Ala Pro > di,, l "35 40 45 Met Ala Leu Tyr Phe Phe Leu Gly Thr Ser Arg Asn Leu Ser Val Gly 50 55 60 Pro Glu Be Thr Thr Ala Leu Met Thr Ala Ala Gly Val Gly Ala Leu 65 70 75 80 Val Gly Ala Ala Gly Gly Pro Glu Arg Tyr Ala Glu Val Ala Ala Ala 85 85 95 Leu Ala He Ala Val Gly He Val Cys Ala Val Gly Phe He Gly Arg 100 105 110 • Leu Gly Phe Leu Thr Arg Leu Leu Ser Arg Pro Val Leu Val Gly Tyr 115 120 125 Leu He Gly He Ala Val Leu Met He Val Ser Gln Leu Ser Lys Val 130 135 140 Thr Gln Val Asn Val Glu Ser Gly Gln Thr Trp Gln Glu He He Ser 145 150 155 160 Phe He Lys Val Ala Gly Gln Ala His He Pro Thr Val He Leu Wing 165 170 175 Val Val Val Leu Ser Leu Leu Tyr Leu Wing Asn Trp Leu Thr Pro Lys 180 185 190 Phe Pro Ser Thr Leu Met Val Leu Leu Leu Ser Ala Ala Wing Val Gly 10 195 200 205 Phe Phe His Leu Asp Arg Phe Gly Leu Glu Val He Gly Glu Val Pro 210 215 220 Arg Gly Leu Pro Gln Pro Ser He Pro Ser He Gly Asp Leu Glu He • 225 230 235 240 Trp Ser Leu Leu Pro Tyr Wing Val Gly He Wing He Val Gly Phe Ser 245 250 255 Asp Asn Val Leu Thr Wing Arg Wing Phe Wing Being Gly Lys Asp Glu Val 260 265 270 He Asp Being Asn Gln Glu Leu Leu Ala Leu Gly Thr Ala Asn Leu Ala 275 280 285 Asn Gly Phe Phe Gln Gly Phe Pro Val Ser Ser Ser Gly Ser Arg Thr 15 290 295 300 Val Leu Gly Asp Thr Ala Gly Ala Arg Thr Gln Val His Ser Leu Val 305 310 315 320 Val Val Ala Leu Val He Met Val Leu Leu Phe Ala Gly Pro Val Leu 325 330 335 Glu Ser Phe Pro Asp Ala Ala Leu Gly Ala Leu Val He Tyr Ala Ala 340 345 350 Thr Gln Leu He Asp He Wing Glu He Lys Arg He Wing Arg Phe Arg 355 360 365 Lys Ser Glu Leu Val He Thr Wing Wing Thr Wing Wing Val Val Wing 370 375 380 Ser Gly Val Leu Wing Gly He Gly Val Wing Val Thr Leu Ser He Leu 20 385 390 395 400 Asp Leu He Arg Arg He Thr Arg Pro Tyr Wing Asp Val Leu Gly Tyr 405 410 415 Thr Pro Gly Met Wing Gly Met His Ser Leu Glu Asp Tyr Pro Glu Ser 420 425 430 Thr Wing Val Glu Gly Leu Val Val Phe Arg Tyr Asp Pro Pro Leu Phe 435 440 445 Phe Wing Asn Wing Asp Asp Phe Ser Lys Arg Wing He Glu Wing Val Asp 450 455 460 Glu Wing Thr Gln Pro Val His Trp Phe Leu Leu Asn Wing Glu Ala Asn 465 470 475 480 Thr Glu Val Asp Leu Thr Ala Val Asp Ala Met Glu Ala Leu Arg Lys 25 485 490 495 Thr Leu Glu Glu Arg Gly He Arg Phe Wing Met Wing Arg Val Lys Gln 500 505 510 Asp Leu Arg Arg Ser Leu Glu Pro Wing Gly Phe He Glu Ser Val Gly 515 520 525 Glu Glu Tyr He Phe Wing Thr Leu Pro Thr Wing Val Lys Gly Tyr Ser 530 535 540 Val Glu Phe Arg Asp Arg Phe Gly Asn Tyr Pro Glu Gly Val Pro Lys 545 550 555 560 Glu He Leu Glu Leu • 565 < 210 > 617 < 211 > 1734 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1711) < 223 > RXA02634 10 < 400 > 617 caacgcgaag < gctt; agttgt ttatt; acegg ct < cacctacc cgg; aggttege; agadtttctt 60 aaggtgagcc < gctcactaitt aaagaggatg gctggcgaag atg cgt gac ctt tta 115 • Met Arg Asp Leu Leu 1 5 ccc tet aga gac gac tat cag cta etc cgc ttc tcc tgg aag atg gac 163 Pro Ser Arg Asp Asp Tyr Gln Leu Leu Arg Phe Ser Trp Lys Met Asp 10 15 20 att gct gct gct gcg gcg gcg att gtt gcc gcc etc. ccc etc gct etc 211 He Wing Wing Wing Val Thr Val Gly He Val Wing Leu Pro Leu Wing Leu 25 30 35 15 gcc ttt ggt gtg agt tet gga gtc gga gcc gag gga gga tta gtg act 259 Wing Phe Gly Val Ser Ser Gly Val Gly Wing Glu Wing Gly Leu Val Thr 40 45 50 gcg att att gct ggc ctg gtt gca gca ate ttc ggc ggt tcc aat gtg 307 Wing He He Wing Wing Gly Leu Val Wing Wing He Phe Gly Gly Ser Asn Val 55 60 65 cag gtt tca gga cca here gga gcg atg gtg gtt gtt etc gct cca ate 355 Gln Val Ser Gly Pro Thr Gly Wing Met Val Val Val Leu Ala Pro He 70 75 80 85 gtc gcc ca g tat gg gt ggt gcg gtt gca gt tta etc age ctg atg gct 403 Val Ala Gln Tyr Gly Val Gly Ala Val Ala Leu Leu Ser Leu Met Wing 90 95 100 20 g9a gtt ate gtc ctt gtc gcc gga gtg ctt cga cta tta ggc cga acg gtg 451 Gly Val He Val Leu Val Wing Gly Val Leu Arg Leu Gly Arg Thr Val 105 110 115 agt ttc att ccg tgg ccg gtc ate gaa gga ttt acg gca ggc ate ggt 499 Ser Phe He Pro Trp Pro Val He Glu Gly Phe Thr Wing Gly He Gly 120 125 130 gtg att att ttc ctg caa gg gg cg gcg gtt ttt ggt tat cg ggc 547 Val He He Phe Leu Gln Gln Val Pro Ala Wing Phe Gly Tyr Ser Gly 135 140 145 cat ttg ccc acc aat gcg etc etc gct gcg att falls act gtt tca falls 595 His Leu Pro Thr Asn Wing Leu Leu Wing Wing His Thr Val Ser His 150 155 160 165 25 9C acg aag gac gca att cta ect etc tta att att ate gtc acc gct 643 Wing Thr Lys Asp Wing He Leu Pro Leu Leu He He He Val Thr Wing 170 175 180 gcg ate atg att gtg ttg gga aag ate gcc cca aag etc ect gcc age 691 Ala He Met He Val Leu Gly Lys He Ala Pro Lys Leu Pro Ala Ser 185 190 195 ttc att gcc att ttg gtg gtg tcc att ggc gtg gct ctg etc aag ctt 739 Phe He Wing He Leu Val Val Ser He Gly Val Wing Leu Leu Lys Leu 200 205 210 r CCC gtt gag ttg ate ggt gag etc ccc aat tcc ctt ect gcc ect cae 787 • Pro Val Glu Leu He Gly Glu Leu Pro Asn Ser Leu Pro Pro Pro His 215 220 225 ctg ect gat gtg aac ctg gag atg ttc acg agt ttg ctg ggg cca gct 835 Leu Pro Asp Val Asn Leu Glu Met Phe Thr Ser Leu Leu Gly Pro Wing 230 235 240 245 ttt gct gcg gcc gcg etc gct gct att gag tet etc ctt cct tcc gct 883 Phe Wing Val Wing Wing Leu Wing Wing He Glu Ser Leu Leu Ser Wing Arg 250 255 260 gtg gca gcc tcc atg gcc gat acg ggt ect tat aat gct gac cgc gaa 931 Val Ala Ala Ser Met Wing Asp Thr Gly Pro Tyr Asn Wing Asp Arg Glu 265 270 275 10 ttg gtc ggt cag ggg ttg gcg tcg ata age gct ggc ttt ttt ggc ggc 979 Leu Val Gly Gln Gly Leu Wing Be He Wing Wing Gly Phe Phe Gly Gly 280 285 290 atg ccg gca act ggc gca ate gcg cgt acg gcg gtc aat gtg cgc tcc 1027 • Met Pro Wing Thr Gly Wing Wing Wing Arg Thr Wing Val Asn Val Arg Ser 295 300 305 ggc ggg cgt acc cgt ata gcg tcg att att drops gcg ctt gtg ctg etc 1075 Gly Gly Arg Thr Arg He Wing Ser He He His Wing Ala Leu Val Leu Leu 310 315 320 325 ggc gtt gtg tat gtg gcg aat ate gtt gcg gtc att ccg etc gcc 1123 Gly Val Val Tyr Val Ala Wing Asn He Val Wing Val He Pro Leu Wing 330 335 340 15 9ca ctg tcg ggc gtg etc atg gtc acc gcg age cgc atg gtg tcc att 1171 Wing Leu Ser Gly Val Leu Met Val Thr Wing Being Arg Met Val Ser He 345 350 355 gaa gtg ate tcg cgc gtc atg cgc tcc act cgc tet gat gcg ate gtt 1219 Glu Val He Ser Arg Val Met Arg Ser Thr Arg Ser Asp Ala He Val 360 365 370 ttt gtc ate acc gcg ate gtc acc ate age gtc gac etc gtc att gcg 1267 Phe Val He Thr Ala He Val Thr He Ser Val Asp Leu Val He Wing 375 380 385 gtc ggc ate ggc att gcc gtc gcg acg ttc ttc atg ctg cga cgc atg 1315 Val Gly He Gly He Wing Val Wing Thr Phe Phe Met Leu Arg Arg Met 390 395 400 405 20 a9c atg aac gcc ggc gtc gtc ttc cgg gaa acc ttg ccc gaa ccg gcc acg 1363 Ser Met Asn Wing Gly Val Phe Arg Glu Thr Leu Pro Glu Pro Wing Thr 410 415 420 ctt aac gac gaa aag ate ggc ctt ttc cgt ate gag ggc gca ttg ttc 1411 Leu Asn Asp Glu Lys He Gly Leu Phe Arg He Glu Gly Wing Leu Phe 425 430 435 ttt ggc gca gct gaa cgt ctt tcg cag caa ate ctt gat tat gag gac 1459 Phe Gly Ala Wing Glu Arg Leu Ser Gln Gln He Leu Asp Tyr Glu Asp 440 445 450 etc gaa gtg gtg ate ctg cgc ctg tca falls ate caa atg ate gac gcc 1507 Leu Glu Val Val He Leu Arg Leu Ser His He Gln Met He Asp Ala 455 460 465 >; 5 acc ggc gcc falls cag etc acc gag ctt gtc aat gcg ctg gaa aga aaa 1555 Thr Gly Ala His Gln Leu Thr Glu Leu Val Asn Ala Leu Glu Arg Lys 470 475 480 485 aat gtc act gta tta att aag ggc gtc cgg aaa gaa falls att falls gtt 1603 Asn Val Thr Val Leu He Lys Gly Val Arg Lys Glu His He His Val 490 495 500 etc ggc gtc etc gga gcg ate aga tca ctg cgg cat gag aac falls etc 1651 Leu Gly Val Leu Gly Ala He Arg Ser Leu Arg His Glu Asn His Leu 505 510 515 ttc gat gac ctt gcc cca gcg gtt gaa cat gcc cga aaa falls gtt aag 1699 • Phe Asp Asp Leu Ala Pro Ala Val Glu His Ala Arg Lys His Val Lys 520 525 530 ate gac aac agt taaggcttcc ggggcgatct aaa 1734 He Asp Asn Ser 535 < 210 > 618 < 211 > 537 < 212 > PRT < 213 > Corynebacterium glutamicum 10 < 400 > 618 Met Arg Asp Leu Leu Pro Being Arg Asp Asp Tyr Gln Leu Leu Arg Phe 1 5 10 15 Being Trp Lys Met Asp He Wing Wing Gly Val Thr Val Gly He Val Wing • 20 25 30 Leu Pro Leu Ala Leu Wing Phe Gly Val Be Ser Gly Val Gly Ala Glu 35 40 45 Wing Gly Leu Val Thr Wing He He Wing Gly Leu Val Wing Wing He Phe 50 55 60 Gly Gly Ser Asn Val Gln Val Ser Gly Pro Thr Gly Wing Met Val Val 65 70 75 80 Val Leu Wing Pro He Val Wing Gln Tyr Gly Val Gly Wing Val Wing Leu 15 85 90 95 Leu Ser Leu Met Wing Gly Val He Val Leu Val Wing Gly Val Leu Arg 100 105 110 Leu Gly Arg Thr Val Ser Phe He Pro Pro Val Val He Glu Gly Phe 115 120 125 Thr Wing Gly He Gly Val He He Phe Leu Gln Gln Val Pro Wing Wing 130 135 140 Phe Gly Tyr Ser Gly His Leu Pro Thr Asn Ala Leu Leu Ala Wing He 145 150 155 160 • His Thr Val Ser His Wing Thr Lys Asp Wing He Leu Pro Leu Leu He 165 170 175 He He Val Thr Ala Wing He Met He Val Leu Gly Lys He Wing Pro 20 180 185 190 Lys Leu Pro Wing Being Phe He Wing He Leu Val Val Being He Gly Val 195 200 205 Wing Leu Leu Lys Leu Pro Val Glu Leu He Gly Glu Leu Pro Asn Ser 210 215 220 Leu Pro Wing Pro His Leu Pro Asp Val Asn Leu Glu Met Phe Thr Ser 225 230 235 240 Leu Leu Gly Pro Wing Phe Wing Val Wing Wing Leu Ala Ala He Glu Ser 245 250 255 Leu Leu Ser Ala Arg Val Ala Ala Ser Met Wing Asp Thr Gly Pro Tyr 260 265 270 Asn Wing Asp Arg Glu Leu Val Gly Gln Gly Leu Wing Ser Be Wing 25 275 280 285 Í4Í..Í.¿. , i? 4 l, .. 4L4 ^^ r. ....- ^ ^ r. to.

Gly Phe Phe Gly Gly Met Pro Wing Thr Gly Wing He Wing Arg Thr Wing 290 295 300 Val Asn Val Arg Ser Gly Gly Arg Thr Arg He Wing Ser He He His 305 310 315 320 Wing Leu Val Leu Val Gw Val Val Tyr Val Wing Ala Asn He Val Ala 325 330 335 Val He Pro Leu Ala Ala Leu Ser Gly Val Leu Met Val Thr Ala Ser 340 345 350 Arg Met Val Ser He Glu Val He Ser Arg Val Met Arg Ser Thr Arg • 355 360 365 Ser Asp Ala He Val Phe Val He Thr Wing He Val Thr He Ser Val 370 375 380 Asp Leu Val He Wing Val Gly He Gly He Wing Val Wing Thr Phe Phe 385 390 395 400 Met Leu Arg Arg Met Ser Met Asn Wing Gly Val Phe Arg Glu Thr Leu 405 410 415 Pro Glu Pro Wing Thr Leu Asn Asp Glu Lys He Gly Leu Phe Arg He 420 425 430 Glu Gly Ala Leu Phe Phe Gly Ala Wing Glu Arg Leu Ser Gln Gln He 435 440 445 10 Leu Asp Tyr Glu Asp Leu Glu Val Val He Leu Arg Leu Ser His He 450 455 460 Gln Met He Asp Wing Thr Gly Wing His Gln Leu Thr Glu Leu Val Asn 465 470 475 480 • Wing Leu Glu Arg Lys Asn Val Thr Val Leu He Lys Gly Val Arg Lys 485 490 495 Glu His He His Val Leu Gly Val Leu Gly Ala He Arg Ser Leu Arg 500 505 510 His Glu Asn His Leu Phe Asp Asp Leu Ala Pro Wing Val Glu His Wing 515 520 525 Arg Lys His Val Lys He Asp Asn Ser 530 535 15 < 210 > 619 < 211 > 1410 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1387) < 223 > RXN02233 < 400 > 619 20 atccccaccc aattggccca agagctgcag agttacgttg tagaacccac ctctgcctaa 60 ctgtcgattt cccaagagcc cccttgggag tcgataatta gtg etc gtg act tca 115 Val Leu Val Thr Ser 1 5 here tgg gga tgg acc gtc falls gga gac ggc aaa aag ate gaa ccc ggc 163 Thr Trp Gly Trp Thr Val His Gly Asp Gly Lys Lys He Glu Pro Gly 10 15 20 gca gtt gtc gct ect aaa gag cgc ctg age tgg ggg cgc here att gga 211 Ala Val Val Ala Pro Lys Glu Arg Leu Ser Trp Gly Arg Thr He Gly 25 30 35 ate ggt atg cag falls gtg ate gcc atg ttc ggc gcc acg etc ctg gtt 259 He Gly Met Gln His Val He Wing Met Phe Gly Wing Thr Leu Leu Val 25 40 45 50 ItLÍt? T? »* .." ^. , ..._ »» _ «. tt. , r ... 4. , r. «. > «.,«, I ccc here etc acc gga ttt ccg gtc aac acc a cta tta ttc tet ggt 307 Pro Thr Leu Thr Gly Phe Pro Val Asn Thr Thu Leu Leu Phe Ser Gly 55 60 65 ctg gga here ate ctg ttc ctg ttg aga acc aga cga cta ccc tcg 355 Leu Gly Thr He Leu Phe Leu Leu He Thr Arg Asn Arg Leu Pro Ser 70 75 80 85 tac ctg ggt agt tet ttt gct ttc att gca ect tta acc acca 403 Tyr Leu Gly Ser Be Phe Wing Phe He Wing Pro Leu Thr Wing Thr Gln 90 95 100 • gtc cat ggc att ggc gtg cag ate ggt ggc att ctt gtc gca ggt etc 451 Val His Gly He Gly Val Gln He Gly Gly He Leu Val Ala Gly Leu 105 110 115 gtg etc gtc gcc att gga ttt gtg gtg aaa gca gcg ggc aaa cgc gtt 499 Val Leu Val Wing He Gly Phe Val Val Lys Wing Wing Gly Lys Arg Val 120 125 130 att gat gct gtc atg cca ccc gct gtc acc ggt gcg ate gtg gca etc 547 He Asp Wing Val Met Pro Pro Wing Val Thr Gly Wing He Val Wing Leu 135 140 145 ate ggc ctg aac ctg gca cca acc gcg gca gga aac ttc tc age caa 595 He Gly Leu Asn Leu Ala Pro Thr Ala Wing Gly Asn Phe Se r Ser Gln 150 155 160 165 10 cca ctg gtt gcc acg gcg acc etc ttt gcc att ttg ate gct acc gtt 643 Pro Leu Val Ala Thr Ala Thr Leu Phe Ala He Leu He Ala Thr Val 170 175 180 • gca ggc cgc gga atg att gct cgc ctg ggc att ttg ate ggt gtg gtg 691 Wing Gly Arg Gly Met He Wing Arg Leu Gly He Leu He Gly Val Val 190 190 195 ate ggc tgg gtt ttc gca gct ate acc ggc aac etc tca gaa ggc gca 739 He Gly Trp Val Phe Wing Wing He Thr Gly Asn Leu Ser Glu Gly Wing 200 205 210 gca gac acc ate cgt gaa gca gca tgg ttc gga ctg cca cag ttc falls 787 Wing Asp Thr He Arg Glu Wing Wing Trp Phe Gly Leu Pro Gln Phe His 15 215 220 225 aag ccg gaa ttc cag etc tet gcc att ttg gtg here ctg cca gtc ate 835 Lys Pro Glu Phe Gln Leu Ser Ala He Leu Val Thr Leu Pro Val He 230 235 240 245 ate gtg etc ate gct gaa aac gtc ggc falls gtc aaa gca gtc tca gag 883 He Val Leu He Wing Glu Asn Val Gly His Val Lys Wing Val Ser Glu 250 255 260 atg here ggg gag gac etc gac gac etc gcc ggc gac gca ctt ate gca 931 Met Thr Gly Glu Asp Leu Asp Asp Leu Wing Gly Asp Wing Leu He Wing 265 270 275 gac gga ttc ggc acc acc gca ggt gcc tcc ggt gga gcc tcc gcc acc 979 Asp Gly Phe Gly Thr Thr Leu Wing Gly Wing Phe Gly Gly Ser Gly Thr 20 280 285 290 acc action tac gca gaac aac ate ggc gtc atc gcg gcc acc gg tat tat 1027 Thr Thr Tyr Ala Glu Asn He Gly Val Met Ala Ala Thr Arg Val Tyr 295 300 305 tcc acc gct gcg tac tgg gtt gcg tgc act gcc ate gcc gcc ctt gcc 1075 Ser Thr Wing Wing Tyr Trp Val Wing Wing Cys Thr Wing Wing Wing Leu Wing 310 315 320 325 ttc ccc aaa ttc ggt gca ctg ate ttc acc ate ccc gcc ggc gtg 1123 Phe He Pro Lys Phe Gly Ala Leu He Phe Thr He Pro Wing Gly Val 330 335 340 ctg ggt ggg gg tgt ttt gtt ctt tac ggc cta ate ggt atg etc ggc 1171 Leu Gly Gly Wing Cys Leu Val Leu Tyr Gly Leu He Gly Met Leu Gly 25 345 350 355 att cgt ate tgg caa gac aac aag gtc aac ttc aac aat cca gtg aat 1219 He Arg He Trp Gln Asp Asn Lys Val Asn Phe Asn Asn Pro Val Asn 360 365 370 ctg acc atg gct gcc gtt gct ttg gtt gca ggc att ggt aac etc ac c 1267 Leu Thr Met Wing Wing Val Wing Leu Val Wing Gly He Gly Asn Leu Thr 375 380 385 etc acc gtt ttc gga gtc act ctt gaa ggc ate gca tgg ggc tet gta 1315 Leu Thr Val Phe Gly Val Thr Leu Glu Gly He Ala Trp Gly Ser Val 390 395 400 405 • ggc ate att gtg ctg tac cca ate atg aag cgc ctg tac ctt tcc att 1363 Gly He He Val Leu Tyr Pro He Met Lys Arg Leu Tyr Leu Ser He 410 415 420 ggg gaa ggc aag aac gca aag ttc tagtacgctg ctaaagtatg cag 1410 Gly Glu Gly Lys Asn Ala Lys Phe 425 < 210 > 620 < 211 > 429 < 212 > PRT < 213 > Corynebacterium glutamicum 10 < 400 > 620 Val Leu Val Thr Ser Thr Trp Gly Trp Thr Val His Gly Asp Gly Lys 1 5 10 15 • Lys He Glu Pro Gly Wing Val Val Wing Pro Lys Glu Arg Leu Ser Trp 20 25 30 Gly Arg Thr He Gly He Gly Met Gln His Val He Wing Met Phe Gly 35 40 45 Wing Thr Leu Leu Val Pro Thr Leu Thr Gly Phe Pro Val Asn Thr Thr 50 55 60 Leu Leu Phe Ser Gly Leu Gly Thr He Leu Phe Leu Leu He Thr Arg 65 70 75 80 15 Asn Arg Leu Pro Being Tyr Leu Gly Being Being Phe Wing Phe He Wing Pro 85 90 95 Leu Thr Wing Thr Gln Val His Gly He Gly Val Gln He Gly Gly He 100 105 110 Leu Val Wing Gly Leu Val Leu Val Wing He Gly Phe Val Val Lys Wing 115 120 125 Wing Gly Lys Arg Val He Asp Wing Val Met Pro Pro Wing Val Thr Gly 130 135 140 Wing He Val Wing Leu He Gly Leu Asn Leu Wing Pro Thr Wing Wing Gly • 145 150 155 160 Asn Phe Be Ser Gln Pro Leu Val Wing Thr Wing Thr Leu Phe Wing He 165 170 175 20 Leu He Wing Thr Val Wing Gly Arg Gly Met He Wing Arg Leu Gly He 180 185 190 Leu He Gly Val Val He Gly Trp Val Phe Wing Wing He Thr Gly Asn 195 200 205 Leu Ser Glu Gly Wing Wing Asp Thr He Arg Glu Wing Wing Trp Phe Gly 210 215 220 Leu Pro Gln Phe His Lys Pro Glu Phe Gln Leu Ser Wing He Leu Val 225 230 235 240 Thr Leu Pro Val He He Val Leu He Wing Glu Asn Val Gly His Val 245 250 255 Lys Wing Val Ser Glu Met Thr Gly Glu Asp Leu Asp Asp Leu Wing Gly 260 265 270 25 Asp Ala Leu He Wing Asp Gly Phe Gly Thr Thr Leu Wing Gl and Ala Phe i ...? .4 .... ... ngnfr. .. r. j .i < ? '- titi "_r" - r? N? T. ___h OLÍ4Í .ta, 275 280 285 Gly Gly Ser Gly Thr Thr Thr Tyr Wing Glu Asn He Gly Val Met Wing 290 295 300 Wing Thr Arg Val Tyr Ser Thr Wing Wing Tyr Trp Val Wing Wing Cys Thr 305 310 315 320 Wing Wing Wing Leu Ala Phe He Pro Lys Phe Gly Ala Leu He Phe Thr 325 330 335 He Pro Wing Gly Val Leu Gly Gly Wing Cys Leu Val Leu Tyr Gly Leu 340 345 350 • He Gly Met Leu Gly He Arg He Trp Gln Asp Asn Lys Val Asn Phe 355 360 365 Asn Asn Pro Val Asn Leu Thr Met Wing Wing Val Wing Leu Val Wing Gly 370 375 380 He Gly Asn Leu Thr Leu Thr Val Phe Gly Val Thr Leu Glu Gly He 385 390 395 400 Wing Trp Gly Ser Val Gly He He Val Leu Tyr Pro He Met Lys Arg 405 410 415 Leu Tyr Leu Ser He Gly Glu Gly Lys Asn Wing Lys Phe 420 425 10 < 210 > 621 < 211 > 1335 < 212 > DNA < 213 > Corynebacterium glutamicum • < 220 > < 221 > CDS < 222 > (101) .. (1312) < 223 > FRXA02233 < 400 > 621 atccccaccc aattggccca agagctgcag agttacgttg tagaacccac ctctgcctaa 60 15 ctgtcgattt cccaagagcc cccttgggag tcgataatta gtg etc gtg act tca 115 Val Leu Val Thr Ser 1 5 here tgg gga tgg acc gtc falls gga gac ggc aaa aag ate gaa ccc ggc 163 Thr Trp Gly Trp Thr Val His Gly Asp Gly Lys Lys He Glu Pro Gly 10 15 20 gca gtt gtc gct ect aaa gag cgc ctg age tgg ggg cgc here att gga 211 Wing Val Val Wing Pro Lys Glu Arg Leu Ser Trp Gly Arg Thr He Gly 25 30 35 • ate ggt atg cag falls gtg ate gcc atg ttc ggc gcc acg etc ctg gtt 259 He Gly Met Gln His Val He Wing Met Phe Gly Ala Thr Leu Leu Val 40 45 50 20 ccc here etc gga ttt ccg gtc aac acc acta ctt tta ttc tet ggt 307 Pro Thr Leu Thr Gly Phe Pro Val Asn Thr Thu Leu Leu Phe Ser Gly 55 60 65 ctg gga here ate ctg ttc ctg ttg ate acc aga aac cga cta ccc tcg 355 Leu Gly Thr He Leu Phe Leu Leu He Thr Arg Asn Arg Leu Pro Ser 70 75 80 85 tac ctg ggt agt tet ttt gct ttc att gca ect tta acc acca 409 Tyr Leu Gly Ser Be Phe Wing Phe He Wing Pro Leu Thr Wing Thr Gln 90 95 100 gtc cat ggc att ggc gtg cag ate ggt ggc att ctt gtc gca ggt etc 451 Val His Gly He Gly Val Gln He Gly Gly He Leu Val Wing Gly Leu 105 110 115 25 gtg etc gtc gcc att gga ttt gtg gtg aaa gca gcg ggc aaa cgc gtt 499 . ^ A? i í. i Val Leu Val Wing He Gly Phe Val Val Lys Wing Wing Gly Lys Arg Val 120 125 130 att gat gct gtc atg cca ccc gct gtc acc ggt gcg ate gtg gca etc 547 He Asp Ala Val Met Pro Pro Ala Val Thr Gly Ala He Val Ala Leu 135 140 145 ate ggc ctg aac ctg gca cca acc gcg gca gga aac ttc tc age caa 595 He Gly Leu Asn Leu Ala Pro Thr Ala Ala Gly Asn Phe Ser Ser Gln 150 155 160 165 cca ctg gtt gcc acg gcg acc etc. ttt gcc att ttg gct att gct acc gtt 643 Pro Leu Val Ala Thr Ala Thr Leu Phe Ala He Leu He Ala Thr Val 170 175 180 gca ggc cgc gg atg att gct cgc ctg ggc att ttg ate ggt gtg gtg 691 Wing Gly Arg Gly Met He Wing Arg Leu Gly He Leu He Gly Val Val 190 190 195 ate ggc tgg gtt ttc gca gct ate acc ggc aac etc tca gaa ggc gca 739 He Gly Trp Val Phe Wing Wing He Thr Gly Asn Leu Ser Glu Gly Wing 200 205 210 gca gac acc ate cgt gaa gca gca tgg ttc gga ctg cca cag ttc falls 787 Wing Asp Thr He Arg Glu Wing Wing Trp Phe Gly Leu Pro Gln Phe His 215 220 225 aag ccg gaa ttc cag etc tet gcc att ttg 835 10 gtg here ctg cca gtc ate Lys Pro Glu Phe Gln Leu Ser Ala He Leu Val Thr Leu Pro Val He 230 235 240 245 ate gtg etc ate gct gaa aac gtc ggc falls gtc aaa gca gtc tca gag 883 • He Val Leu He Ala Glu Asn Val Gly His Val Lys Ala Val Ser Glu 250 255 260 atg here ggg gag gac etc gac gac etc gcc gcc gac gca ctt ate gca 931 Met Thr Gly Glu Asp Leu Asp Asp Leu Wing Gly Asp Wing Leu He Ala 265 270 275 gac gga tcc ggc acc acc gca ggt gcc gtc tgc tgc gga gcc acc 979 Asp Gly Phe Gly Thr Thr Leu Wing Gly Wing Phe Gly Gly Ser Gly Thr 280 285 290 acc action gcc ac cgc gta tat 1027 15 tac gca gaa aac ate ggc gtc atg gcg Thr Thr Tyr Wing Glu Asn He Gly Val Met Wing Wing Thr Arg Val Tyr 295 300 305 tcc acc gct gcg tac tgg gtt gcc gcg tgc act gcc ate gcc ctt gcc 1075 Be Thr Wing Wing Tyr Trp Val Wing Wing Cys Thr Wing Wing Wing Leu Wing 310 315 320 325 ttc ate ccc aaa ttc ggt gca ctg ate ttc acc ate ccc gcc ggc gtg 1123 Phe He Pro Lys Phe Gly Ala Leu He Phe Thr He Pro Ala Gly Val 330 335 340 • ctg ggt ggg gg tgt ttt gtt ctt tac ggc cta ate ggt atg etc ggc 1171 Leu Gly Gly Ala Cys Leu Val Leu Tyr Gly Leu He Gly Met Leu Gly 345 350 355 att cgt ate caa gac aac aac aac gtc aac tc aac aat cca 20 tgg gtg aat 1219 He Arg He Trp Gln Asp Asn Lys Val Asn Phe Asn Asn Pro Val Asn 360 365 370 ctg acc atg gct gcc gtt gt ttg gtt gca ggc att ggt aac etc acc 1267 Leu Thr Met Wing Wing Val Wing Leu Val Wing Gly He Gly Asn Leu Thr 375 380 385 etc acc gtt ttc gga gtc act ctt gaa ggc ate gca tgg gct ctg 1312 Leu Thr Val Phe Gly Val Thr Leu Glu Gly He Wing Trp Ala Leu 390 395 400 tag? Jcatcat t: gtgctgtac cca 1335 <; 210 > 622 25 < 211 > 404 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 622 Val Leu Val Thr Ser Thr Trp Gly Trp Thr Val His Gly Asp Gly Lys 1 5 10 15 Lys He Glu Pro Gly Wing Val Val Wing Pro Lys Glu Arg Leu Ser Trp 20 25 30 Gly Arg Thr He Gly He Gly Met Gln His Val He Wing Met Phe Gly 35 40 45 Wing Thr Leu Leu Val Pro Thr Leu Thr Gly Phe Pro Val Asn Thr Thr 50 55 60 Leu Leu Phe Ser Gly Leu Gly Thr He Leu Phe Leu Leu He Thr Arg 65 70 75 80 Asn Arg Leu Pro Being Tyr Leu Gly Being Being Phe Wing Phe He Wing Pro 85 90 95 Leu Thr Wing Thr Gln Val His Gly He Gly Val Gln He Gly Gly He 100 105 110 Leu Val Wing Gly Leu Val Leu Val Wing He Gly Phe Val Val Lys Wing 115 120 125 10 Wing Gly Lys Arg Val He Asp Wing Val Met Pro Pro Wing Val Thr Gly 130 135 140 Wing He Val Wing Leu He Gly Leu Asn Leu Wing Pro Thr Wing Wing Gly 145 150 155 160 • Asn Phe Be Ser Gln Pro Leu Val Wing Thr Wing Thr Leu Phe Wing He 165 170 175 Leu He Wing Thr Val Wing Gly Arg Gly Met He Wing Arg Leu Gly He 180 185 190 Leu He Gly Val Val He Gly Trp Val Phe Wing Wing He Thr Gly Asn 195 200 205 Leu Ser Glu Gly Wing Wing Asp Thr He Arg Glu Wing Wing Trp Phe Gly 210 215 220 15 Leu Pro Gln Phe His Lys Pro Glu Phe Gln Leu Ser Wing He Leu Val 225 230 235 240 Thr Leu Pro Val He He Val Leu He Wing Glu Asn Val Gly His Val 245 250 255 Lys Wing Val Ser Glu Met Thr Gly Glu Asp Leu Asp Asp Leu Wing Gly 260 265 270 Asp Wing Leu He Wing Asp Gly Phe Gly Thr Thr Leu Wing Gly Wing Phe 275 280 285 Gly Gly Ser Gly Thr Thr Thr Tyr Wing Glu Asn He Gly Val Met Wing • 290 295 300 Wing Thr Arg Val Tyr Ser Thr Wing Wing Tyr Trp Val Wing Wing Cys Thr 305 310 315 320 20 Wing Wing Wing Leu Wing Phe He Pro Lys Phe Gly Wing Leu He Phe Thr 325 330 335 He Pro Wing Wing Gly Val Leu Gly Gly Wing Cys Leu Val Leu Tyr Gly Leu 340 345 350 He Gly Met Leu Gly He Arg He Trp Gln Asp Asn Lys Val Asn Phe 355 360 365 Asn Asn Pro Val Asn Leu Thr Met Ala Ala Val Ala Leu Val Ala Gly 370 375 380 He Gly Asn Leu Thr Leu Thr Val Phe Gly Val Thr Leu Glu Gly He 385 390 395 400 Wing Trp Ala Leu 25 < 210 > 623 < 211 > 2010 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1987) < 223 > RXN02372 • < 400 > 623 gacaatactg, atggataaat ttcatatcg, a ggaegaaggg acaacccicga, acgccgtgac 60 aacatcaacc, acaaicccggg tgaaacatcc ggtagaccag gtg cca ccc gcc ccc 115 Val Pro Pro Ala Pro 1 5 aaa ctt gc gcc cta ggg etc caa falls gtt ctt gct ttc tac gca gga 163 Lys Leu Ala Ala Leu Gly Leu Gln His Val Leu Ala Phe Tyr Ala Gly 10 15 20 gcc gtc att gtt ccg ctg ctg att gca cag tcg ctg aac ttg gac act 211 Ala Val He Val Pro Leu Leu He Ala Gln Ser Leu Asn Leu Asp Thr 25 30 35 acc 10 gcg acc att falls ctg att aac gct gac ttg ttg here tgt ggc ate 259 Ala Thr Thr He His Leu He Asn Wing Asp Leu Leu Thr Cys Gly He 40 45 50 gcc acg ttg att cag tet gtg ggc att ggt cgc falls att ggt gtg cgc 307 • Wing Thr Leu He Gln Ser Val Gly He Gly Arg His He Gly Val Arg 55 60 65 cta ccg ate gtt caa ggt gtc acc act act gct gtt ccc ate ate 355 Leu Pro He Val Gln Gly Val Thr Thr Thr Ala Val Ala Pro He He 70 75 80 85 gcc att ggt ttg ggc gtt act gat ggt caa ggt ggc gtt gcg tcg ctg 403 Wing He Gly Leu Gly Val Thr Asp Gly Gln Gly Val Wing Ser Leu 90 95 100 15 cct gcc att tac ggt gca gtc att gtc tcc ggc att ttc acg ttc ttt 451 Pro Ala He Tyr Gly Ala Val He Val Ser Gly He Phe Thr Phe Phe 105 110 115 gca gcg ccg gtg ttt gcg cgt ttc etc aag ttc ttc cca cca gtt gtc 499 Ala Ala Pro Val Phe Ala Arg Phe Leu Lys Phe Phe Pro Pro Val Val 120 125 130 acc ggt act gtg ctg ttg gtt atg ggt gct tcc ctg ctg tcg gta tet 547 Thr Gly Thr Val Leu Leu Val Met Gly Wing Ser Leu Leu Ser Val Ser 135 140 145 gca aat gac ttt gtg aac tac gcc gat ggg gtg cct gct gcc cgc gat 595 Wing Asn Asp Phe Val Asn Tyr Wing Asp Gly Val Pro Wing Wing Arg Asp 150 155 160 165 20 ctt gct tac ggt ttt ggc acc ttg gcg gtg ate att ttg gcg cag cgc 643 Leu Ala Tyr Gly Phe Gly Thr Leu Ala Val He He Leu Ala Gln Arg 170 175 180 ttc ttc cgt gga ttc atg ggc acc ttg gct gtg ttg ate ggc ctg gtt 691 Phe Phe Arg Gly Phe Met Gly Thr Leu Wing Val Leu He Gly Leu Val 185 190 195 ggt ggc gc gtc gtt gct ctg ate gtc gtc gat gcc aac ttg gat gag 739 Gly Gly Thr Wing Val Wing Leu He Leu Gly Asp Wing Asn Leu Asp Glu 200 205 210 gtg gga aat gct gac gcg ttc gac ate acc act ccg ttt tat ttt ggt 787 Val Gly Asn Wing Glu Wing Phe Asp He Thr Thr Pro Phe Tyr Phe Gly 215 220 225 25 gtt cca gaa ttt aac gct gtt gcc att ttc tcc atg att ate gtc atg 835 ? íí,? .-? -.i.ar.4.

Val Pro Glu Phe Asn Wing Val Wing He Phe Ser Met He He Val Met 230 235 240 245 ate ate acc atg gtg gag acc acc ggt gat gtg ttt gca acg ggg gaa 883 He He Thr Met Val Glu Thr Thr Gly Asp Val Phe Ala Thr Gly Glu 250 255 260 ate gtc ggc aag cga act cgc cgc agt gat gtc acc cgc gca ctg cgc 931 He Val Gly Lys Arg Thr Arg Arg Ser Asp Val Thr Arg Ala Leu Arg 265 270 275 gct gac ggc ctg tcc acc ctg atg ggt ggc gtc atg aac tcc tcc ccg 979 Wing Asp Gly Leu Ser Thr Leu Met Gly Gly Val Met Asn Ser Phe Pro 280 285 290 tac acg tgc tcc gcg caa aac gtt ggc ctg gtg cgc ate acg ggc gtg 1027 Tyr Thr Cys Phe Ala Gln Asn Val Gly Leu Val Arg He Thr Gly Val 295 300 305 aaa tet cgc tgg gg ggg gcg gct gct gcc gc gtc atc ate ate 1075 lys ser arg trp val wing wing wing wing wing wing gly phe met he he leu 310 315 320 325 ggt gtg ctg ccc aag gct ggc gcg ate gtc gct tcc cct ccc tcc cca 1123 Gly Val Leu Pro Lys Wing Gly Wing He Val Wing Ser Pro Pro 330 335 340 gtc etc ggt ggc gca tcc ttg gca ctg tcc gcc aac gtt gca tgg gtg 1171 Val Leu Gly Gly Ala Ser Leu Wing Leu Phe Wing Asn Val Wing Trp Val 345 350 355 ggc ate cag acc ate gcc aag tet gac etc gct gat age cgc aac tcc 1219 Gly He Gln Thr He Ala Lys Ser Asp Leu Wing Asp Ser Arg Asn Ser 360 365 370 gtc ate gtg acc tcc gca ctt ggc cta gcc atg ctg gtg tcc tcc cgc 1267 Val He Val Thr Ser Ala Leu Gly Leu Ala Met Leu Val Ser Phe Arg 375 380 385 ccc gat gtt gcg cag gcg cct gag tgg gcg cgt ate ttc gtc tcc 1315 Pro Asp Val Ala Gln Ala Phe Pro Glu Trp Ala Arg He Phe Val Ser 390 395 400 405cc ggc atg tcc gtc ggc gcg ate acc gcg ate ctg ctt aac ctg ctg 1363 Ser Gly Met Ser Val Gly Ala He Thr Ala He Leu Leu Asn Leu Leu 410 415 420 ttc ttc falls gtc gga cgc caa tcc ggt gga caa gtc gct acc tca aaa 1411 Phe Phe His Val Gly Arg Gln Be Gly Gly Gln Val Wing Thr Ser Lys 425 430 435 tcc ggt gag cgc ate aat ttg gat gcg gtc aac aag atg gat cgc acc 1459 Ser Gly Glu Arg He Asn Leu Asp Wing Val Asn Lys Met Asp Arg Thr 440 445 450 gac ttc gta gaa acc ttc gca ccg ctg ttc aac age aag acc tgg cct 1507 Asp Phe Val Glu Thr Phe Ala Pro Leu Phe Asn Ser Lys Thr Trp Pro 455 460 465 ttg gaa acc gca tgg gaa tcc cag cca ttc gcc aac gtc acg gaa ctg 1555 Leu Glu Thr Wing Trp Glu Ser Gln Pro Phe Wing Asn Val Thr Glu Leu 470 475 480 485 cgc gaa gcc ate caa gtc gct gtg etc acc gca ccg ttg tcc gac cgc 1603 Arg Glu Wing He Gln Val Wing Val Leu Thr Al a Pro Leu Ser Asp Arg 490 495 500 Gaa Gag Etc Fall Gac Tac Ccc Gac Atg Gca Cag etc Att Ttg Gcc 1651 Glu Glu Leu He As Asp Tyr Pro Asp Met Wing Gln Leu He Leu Wing 505 510 515 acc gaa gag gaa gcc gcc acc ate tet caa gac cgt ggt tcg ate ggt 1699 Thr Glu Glu Glu Wing Wing Thr He Ser Gln Asp Arg Gly Ser He Gly 520 525 530 ctt gat gat etc gat gac gtg gat caa gaa aag etc ate acc gtc acc 1747 Leu Asp Asp Leu Asp Asp Val Asp Gln Glu Lys Leu He Thr Val Thr 535 540 545 gag cag tac cgc gaa cgg ttc aac atg ccg tat gtt gcg tac tcc gac 1795 Glu Gln Tyr Arg Glu Arg Phe Asn Met Pro Tyr Val Ala Tyr Phe Asp 550 555 560 565 acc atg gat tet gtg gat acc gtc gta gcc gcc ggc tgc cgc cgc etc 1843 Thr Met Asp Ser Val Asp Thr Val Val Wing Wing Gly Leu Arg Arg Leu 570 575 580 gac aac tcc gac gag cag gag falls cgc caa gcg cta tcg gaa ate att 1891 Asp Asn Ser Asp Glu Gln Glu His Arg Gln Ala Leu Ser Glu He He 585 590 595 gag att gcc aat gac cgc ttc gat ata ttg ctt gcc gac gct aac cca 1939 Glu He Ala Asn Asp Arg Phe Asp He Leu Leu Wing Asp Wing Asn Pro 600 605 610 gcc cgt tca gct tcc gat cgc aag ttt acc gag act gac ttc etc ggc 1987 Wing Arg Wing Wing Phe Asp Arg Lys Phe Thr Glu Thr Asp Phe Leu Gly 615 620 625 taaaacacca aaaacaaatt aag 2010 <; 210 > 624 10 < 211 > 629 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 624 • Val Pro Pro Wing Pro Lys Leu Wing Wing Leu Gly Leu Gln His Val Leu 1 5 10 15 Wing Phe Tyr Wing Wing Wing Val Hew Pro Leu Leu Wing Wing Gln Ser 20 25 30 Leu Asn Leu Asp Thr Wing Thr Thr He His Leu He Asn Wing Asp Leu 35 40 45 Leu Thr Cys Gly He Wing Thr Leu He Gln Ser Val Gly He Gly Arg 15 50 55 60 His He Gly Val Arg Leu Pro He Val Gln Gly Val Thr Thr Thr Ala 65 70 75 80 Val Ala Pro He He Ala He Gly Leu Gly Val Thr Asp Gly Gln Gly 85 90 95 Gly Val Ala Ser Leu Pro Ala He Tyr Gly Ala Val He Val Ser Gly 100 105 110 He Phe Thr Phe Phe Ala Ala Pro Val Phe Ala Arg Phe Leu Lys Phe 115 120 125 • Phe Pro Pro Val Val Thr Gly Thr Val Leu Leu Val Met Gly Wing Ser 130 135 140 Leu Leu Ser Val Ser Wing Asn Asp Phe Val Asn Tyr Wing Asp Gly Val 20 145 150 155 160 Pro Wing Ala Arg Asp Leu Ala Tyr Gly Phe Gly Thr Leu Ala Val He 165 170 175 He Leu Ala Gln Arg Phe Phe Arg Gly Phe Met Gly Thr Leu Ala Val 180 185 190 Leu He Gly Leu Val Gly Gly Thr Ala Val Ala Leu He Leu Gly Asp 195 200 205 Wing Asn Leu Asp Glu Val Gly Asn Wing Glu Wing Phe Asp He Thr Thr 210 215 220 Pro Phe Tyr Phe Gly Val Pro Glu Phe Asn Wing Val Wing He Phe Ser 225 230 235 240 Met He He Val Met He He Thr Met Val Glu Thr Thr Gly Asp Val 25 245 250 255 ? _ -. , ... ^. ^ -. ...,. , _., ^. ,. "., -. i & * í ?? r., Phe Wing Thr Gly Glu He Val Gly Lys Arg Thr Arg Arg Ser Asp Val 260 265 270 Thr Arg Ala Leu Arg Wing Asp Gly Leu Ser Thr Leu Met Gly Val 275 280 285 Met Asn Ser Phe Pro Tyr Thr Cys Phe Wing Gln Asn Val Gly Leu Val 290 295 300 Arg He Thr Gly Val Lys Ser Arg Trp Val Wing Wing Wing Wing Wing Gly 305 310 315 320 Phe Met He He Leu Gly Val Leu Pro Lys Wing Gly Wing Val Ala • 325 330 335 Ser He Pro Pro Pro Val Leu Gly Gly Ala Ser Leu Ala Leu Phe Wing 340 345 350 Asn Val Wing Trp Val Gly He Gln Thr He Wing Lys Ser Asp Leu Wing 355 360 365 Asp Ser Arg Asn Ser Val He Val Thr Ser Wing Leu Gly Leu Wing Met 370 375 380 Leu Val Ser Phe Arg Pro Asp Val Wing Gln Wing Phe Pro Glu Trp Wing 385 390 395 400 Arg He Phe Val Ser Ser Gly Met Ser Val Gly Wing He Thr Wing He 405 410 415 10 Leu Leu Asn Leu Leu Phe Phe His Val Gly Arg Gln Ser Gly Gly Gln 420 425 430 Val Wing Thr Ser Lys Ser Gly Glu Arg He Asn Leu Asp Wing Val Asn 435 440 445 • Lys Met Asp Arg Thr Asp Phe Val Glu Thr Phe Wing Pro Leu Phe Asn 450 455 460 Ser Lys Thr Trp Pro Leu Glu Thr Wing Trp Glu Ser Gln Pro Phe Wing 465 470 475 480 Asn Val Thr Glu Leu Arg Glu Wing He Gln Val Wing Val Leu Thr Wing 485 490 495 Pro Leu Be Asp Arg Glu Glu Glu Leu He As Asp Tyr Pro Asp Met Wing 500 505 510 15 Gln Leu He Leu Wing Thr Glu Glu Glu Wing Wing Thr He Ser Gln Asp 515 520 525 Arg Gly Ser He Gly Leu Asp Asp Leu Asp As p Val Asp Gln Glu Lys 530 535 540 Leu He Thr Val Thr Glu Gln Tyr Arg Glu Arg Phe Asn Met Pro Tyr 545 550 555 560 Val Wing Tyr Phe Asp Thr Met Asp Ser Val Asp Thr Val Val Wing Wing 565 570 575 Gly Leu Arg Arg Leu Asp Asn Ser Asp Glu Gln Glu His Arg Gln Ala • 580 585 590 Leu Ser Glu He He Glu He Wing Asn Asp Arg Phe Asp He Leu Leu 595 600 605 20 Wing Asp Wing Asn Pro Wing Arg Wing Wing Ashe Arg Lys Phe Thr Glu 610 615 620 Thr Asp Phe Leu Gly 625 < 210 > 625 < 211 > 578 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS 25 < 222 > (1) .. (555) ^^^^^^^^^^^ ^ ^ 223 > FRXA02372 < 400 > 625 gat gcg gtc aac aag atg gat cgc acc gac ttc gta gaa acc ttc gca 48 Asp Wing Val Asn Lys Met Asp Arg Thr Asp Phe Val Glu Thr Phe Wing 1 5 10 15 ccg ctg ttc aac age aag acc tgg cct ttg gaa acc gca tgg gaa tcc 96 Pro Leu Phe Asn Ser Lys Thr Trp Pro Leu Glu Thr Wing Trp Glu Ser 20 25 30 • cag cca ttc gcc aac gtc acg gaa ctc cgc gaa gcc ate caa gtc gct 144 Gln Pro Phe Ala Asn Val Thr Glu Leu Arg Glu Wing He Gln Val Wing 35 40 45 gtg etc acc gca ccg ttg tcc gac cgc gaa gag etc ate drops gac tac 192 Val Leu Thr Wing Pro Leu Ser Asp Arg Glu Glu Leu He His Asp Tyr 50 55 60 ccc gac atg gca cag etc att ttg gcc acc gaa gag gaa gcc gcc acc 240 Pro Asp Met Wing Gln Leu He Leu Wing Thr Glu Glu Glu Wing Wing Thr 65 70 75 80 ate tet caa gac cgt ggt tcg ate ggt ctt gat gat etc gat gac gtg 288 Be Ser Gln Asp Arg Gly Be He Gly Leu Asp Asp Leu Asp Asp Val 10 85 90 95 gat caa gaa aag etc ate acc gtc acc gag cag tac cgc gaa cgg ttc 336 Asp Gln Glu Lys Leu He Thr Val Thr Glu Gln Tyr Arg Glu Arg Phe 100 105 110 • aac atg ccg tat gtt gcg tac tcc gac acc atg gat tet gtg gat acc 384 Asn Met Pro Tyr Val Wing Tyr Phe Asp Thr Met Asp Ser Val Asp Thr 115 120 125 gtc gta gcc gcc ggc ttg cgc cgc etc gac aac tcc gac gag gag cag gag 432 Val Val Ala Ala Gly Leu Arg Arg Leu Asp Asn Ser Asp Glu Gln Glu 130 135 140 falls cgc caa gcg cta tcg gaa ate att gag att gcc aat gac cgc ttc 480 His Arg Gln Ala Leu Ser Glu He He Glu He Wing Asn Asp Arg Phe 15 145 150 155 160 gat ata ttg ctt gcc gac gct aac cca gcc cgt tca gct ttc gat cgc 528 Asp He Leu Leu Wing Asp Wing Asn Pro Wing Arg Wing Wing Phe Asp Arg 165 170 175 aag ttt acc gag act gac ttc etc ggc taaaacacca aaaacaaatt 575 Lys Phe Thr Glu Thr Asp Phe Leu Gly 180 185 aag 578 • < 210 > 626 < 211 > 185 < 212 > PRT 20 < 213 > Ccirynebact: erium glutamicum < 400 > 626 Asp Ala Val Asn Lys Met Asp Arg Thr Asp Phe Val Glu Thr Phe Ala 1 5 10 15 Pro Leu Phe Asn Ser Lys Thr Trp Pro Leu Glu Thr Wing Trp Glu Ser 20 25 30 Gln Pro Phe Wing Asn Val Thr Glu Leu Arg Glu Wing He Gln Val Wing 35 40 45 Val Leu Thr Ala Pro Leu Ser Asp Arg Glu Glu Leu He As Asp Tyr 50 55 60 Pro Asp Met Wing Gln Leu He Leu Wing Thr Glu Glu Glu Wing Wing Thr 25 65 70 75 80 He Ser Gln Asp Arg Gly Ser He Gly Leu Asp Asp Leu Asp Asp Val 85 90 95 Asp Gln Glu Lys Leu He Thr Val Thr Glu Gln Tyr Arg Glu Arg Phe 100 105 110 Asn Met Pro Tyr Val Wing Tyr Phe Asp Thr Met Asp Ser Val Asp Thr 115 120 125 Val Val Wing Wing Gly Leu Arg Arg Leu Asp Asn Ser Asp Glu Gln Glu 130 135 140 His Arg Gln Ala Leu Ser Glu He He Glu He Wing Asn Asp Arg Phe • 145 150 155 160 Asp He Leu Leu Wing Asp Wing Asn Pro Wing Arg Wing Wing Phe Asp Arg 165 170 175 Lys Phe Thr Glu Thr Asp Phe Leu Gly 180 185 <; 210 > 627 < 211 > 1314 < 212 > DNA < 213 > Corynebacterium glutamicum 10 < 220 > < 221 > CDS < 222 > (101) .. (1291) < 223 > FRXA02377 < 400 > 627 gacaatactg atggataaat ttcatatcga ggaegaaggg acaaccccga acgccgtgac 60 aacatcaacc acaacccggg tgaaacatcc ggtagaccag gtg cca ccc gcc ccc 115 Val Pro Pro Ala Pro 1 5 aaa ctt gca gcc cta ggg etc caa falls gtt ctt gct ttc tac gca gga 163 Lys Leu Ala Ala Leu Gly Leu Gln His Val Leu Ala Phe Tyr Ala Gly 15 10 15 20 gcc gtc att gtt ccg ctg ctg att gca cag tcg ctg aac ttg gac act 211 Wing Val He Val Pro Leu Leu He Wing Gln Ser Leu Asn Leu Asp Thr 25 30 35 gcg acc acc att falls ctg att aac gct gac ttg ttg here tgt ggc ate 259 Ala Thr Thr He His Leu He Asn Wing Asp Leu Leu Thr Cys Gly He 40 45 50 gcc acg ttg att cag tet gtg ggc att ggt cgc falls att ggt gtg cgc 307 Wing Thr Leu He Gln Ser Val Gly He Gly Arg His He Gly Val Arg • 55 60 65 cta ccg ate gtt caa ggt gtc acc act act gct gtt ccc ate ate 355 Leu Pro He Val Gln Gly Val Thr Thr Thr Ala Val Ala Pro He He 20 70 75 80 85 gcc att ggt ttg ggc gtt act gat ggt caa ggt ggc gtt gcg tcg ctg 403 Wing He Gly Leu Gly Val Thr Asp Gly Gln Gly Val Wing Ser Leu 90 95 100 cct gcc att tac ggt gca gtc att gtc tcc ggc att ttc acg ttc ttt 451 Pro Ala He Tyr Gly Ala Val He Val Ser Gly He Phe Thr Phe Phe 105 110 115 gca gcg ccg gtg ttt gcg cgt ttc etc aag ttc ttc cca cca gtt gtc 499 Ala Ala Pro Val Phe Ala Arg Phe Leu Lys Phe Phe Pro Pro Val Val 120 125 130 acc ggt act gtg ctg ttg gtt atg ggt gct tcc ctg ctg tcg gta tet 547 Thr Gly Thr Val Leu Leu Val Met Gly Ala Ser Leu Leu Ser Val Ser 25 135 140 145 ¿¿^ ^^ ggfc? Fa¿¿¿¿¿¿¿c gc aat gac ttt gtg aac tac gcc gat gtg cct gct gcc cgc gat 595 Wing Asn Asp Phe Val Asn Tyr Wing Asp Gly Val Pro Wing Wing Arg Asp 150 155 160 165 ctt gct tac ggt ttt ggc acc ttg gcg gtg ate att ttg gcg cag cgc 643 Leu Ala Tyr Gly Phe Gly Thr Leu Ala Val He He Leu Ala Gln Arg 170 175 180 ttc ttc cgt gga ttc atg ggc acc ttg gct gtg ttg ate ggc ctg gtt 691 Phe Phe Arg Gly Phe Met Gly Thr Leu Wing Val Leu He Gly Leu Val 185 190 195 ggt ggc gt gtc gt gct gt ctg ate gt gcg gc gat gcc aac ttg gat gag 739 Gly Gly Thr Ala Wing Ala Leu He Glu Asp Leu Wing Asn Leu Asp Glu 200 205 210 gtg gga aat gct gac gcg ttc gac ate acc act ccg ttt tat ttt ggt 787 Val Gly Asn Wing Glu Wing Phe Asp He Thr Thr Pro Phe Tyr Phe Gly 215 220 225 gtt cca gaa ttt aac gct gtt gcc att ttc tcc atg att ate gtc atg 835 Val Pro Glu Phe Asn Wing Val Wing Phe Ser Met He He Val Met 230 235 240 245 ate ate acc atg gtg gag acc acc ggt gat gtg ttt gca acg ggg gaa 883 He He Thr Met Val Glu Th r Thr Gly Asp Val Phe Wing Thr Gly Glu 10 250 255 260 ate gtc ggc aag cga act cgc agt gat gtc acc cgc gca ctg cgc 931 He Val Gly Lys Arg Thr Arg Arg Ser Asp Val Thr Arg Ala Leu Arg 265 270 275 • gct gac ggc ctg tcc acc ctg atg ggt ggc gtc atg aac tcc ttc ccg 979 Wing Asp Gly Leu Ser Thr Leu Met Gly Gly Val Met Asn Ser Phe Pro 280 285 290 tac acg tgc ttc gcg caa aac gtt ggc ctg gtg cgc ate acg ggc gtg 1027 Tyr Thr Cys Phe Wing Gln Asn Val Gly Leu Val Arg He Thr Gly Val 295 300 305 aaa tet cgc tgg gtt gcg gca gct gct gcc ggc ttc atg ate ate etc 1075 Lys Ser Arg Trp Val Wing Wing Wing, Wing Wing Gly Phe Met He He Leu 15 310 315 320 325 ggt gtg ctg ccc aag gct ggc gcg, ate gtc gct tcc cct cct tcc cca 1123 Gly Val Leu Pro Lys Wing Gly Ala He Val Wing Ser He Pro Ser Pro 330 335 340 gtc etc ggt ggc gca tcc tcg gca, ctg tcc gcc aac gtt gc tgg gtg 1171 Val Leu Gly Gly Ala Ser Leu Wing: Leu Phe Wing Asn Val Wing Trp Val 345 350 355 ggc ate cag acc ate gcc aag tet 1gac etc gct gat a ge cgc aac tcc 1219 Gly He Gln Thr He Wing Lys Ser. Asp Leu Wing Asp Being Arg Asn Ser • 360 365 370 gtc ate gtg acc tcc gca ctt ggc icta gcc atg ctg gtg tcc tcc cgc 1267 Val He Val Thr Ser Ala Leu Gly: Leu Wing Met Leu Val Ser Phe Arg 20 375 380 385 ccc gat gtt gct gt ggc gtt CCC 'tgagtgggcg cgtatcttcg tet 1314 Pro Asp Val Wing Gln Gly Val Pro 390 395 < 210 > 628 < 211 > 397 < 212 > PRT < 213 > Corynebact: er? Um glutamicum < 400 > 628 Val Pro Pro Ala Pro Lys Leu Ala Ala Leu Gly Leu Gln His Val Leu 25 1 5 10 15 Ala Phe Tyr Ala Gly Ala Val He Val Pro Leu Leu He Ala Gln Ser 20 25 30 Leu Asn Leu Asp Thr Ala Thr Thr He His Leu He Asn Ala Asp Leu 35 40 45 Leu Thr Cys Gly He Ala Thr Leu He Gln Ser Val Gly He Gly Arg 50 55 60 His He Gly Val Arg Leu Pro He Val Gln Gly Val Thr Thr Thr Ala 65 70 75 80 Val Ala Pro He He Wing He Gly Leu Gly Val Thr Asp Gly Gln Gly 85 90 95 Gly Val Ala Ser Leu Pro Ala He Tyr Gly Ala Val He Val Ser Gly 100 105 110 He Phe Thr Phe Phe Ala Ala Pro Val Phe Ala Arg Phe Leu Lys Phe 115 120 125 Phe Pro Pro Val Val Thr Gly Thr Val Leu Leu Val Met Gly Wing Ser 130 135 140 Leu Leu Ser Val Ser Wing Asn Asp Phe Val Asn Tyr Wing Asp Gly Val 145 150 155 160 Pro Ala Ala Arg Asp Leu Ala Tyr Gly Phe Gly Thr Leu Ala Val He 165 170 175 He Leu Ala Gln Arg Phe Phe Arg Gly Phe Met Gly Thr Leu Wing Val 180 185 190 Leu He Gly Leu Val Gly Gly Thr Ala Val Ala Leu He Leu Gly Asp 195 200 205 Wing Asn Leu Asp Glu Val Gly Asn Wing Glu Wing Phe Asp He Thr Thr 210 215 220 Pro Phe Tyr Phe Gly Val Pro Glu Phe Asn Wing Val Wing He Phe Ser 225 230 235 240 Met He He Val Met He He Thr Met Val Glu Thr Thr Gly Asp Val 245 250 255 Phe Ala Thr Gly Glu He Val Gly Lys Arg Thr Arg Arg Ser Asp Val 260 265 270 Thr Arg Ala Leu Arg Ala Asp Gly Leu Ser Thr Leu Met Gly Val 275 280 285 Met Asn Ser Phe Pro Tyr Thr Cys Phe Wing Gln Asn Val Gly Leu Val 290 295 300 Arg He Thr Gly Val Lys Ser Arg Trp Val Ala Ala Ala Ala Ala Gly 305 310 315 320 Phe Met He He Leu Gly Val Leu Pro Lys Ala Gly Ala He Val Ala 325 330 335 Ser He Pro Ser Pro Val Leu Gly Gly Wing Ser Leu Wing Leu Phe Wing 340 345 350 Asn Val Wing Trp Val Gly He Gln Thr He Wing Lys Ser Asp Leu Wing 355 360 365 Asp Ser Arg Asn Ser Val He Val Thr Ser Ala Leu Gly Leu Wing Met 370 375 380 Leu Val Ser Phe Arg Pro Asp Val Wing Gln Gly Val Pro 385 390 395 < 210 > 629 < 211 > 1512 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) (1489) < 223 > RXA02676 < 400 > 629 aaccattggg tattaagaaa tttgtggctt agatetcaat ttctgtatag tttg.atcata 60 ctaattcatc icacttccaaa ttttcacga, a ggatcacccc atg gac acc tgg gaa 115 Met Asp Thr Trp Glu 1 5 caa acc ctt gga here ggg cca ctg cta ggc att gca gcc ggc gcc att 163 Gln Thr Leu Gly Thr Gly Pro Leu Leu Gly He Wing Wing Gly Wing He • 10 15 20 gcc etc ate ttg gtt etc gtc ate gtt ttt aaa etc cat gct ttt etc 211 Wing Leu He Leu Val Leu Val He Val Phe Lys Leu His Wing Phe Leu 25 30 35 acc cta ata ctg gtt tca att gtt acc gca ctt gct gcc ggc att ccc 259 Thr Leu He Leu Val Ser He Val Thr Ala Leu Ala Wing Gly He Pro 40 45 50 gtc acc gca gta gtg gac act etc ctt gac ggt ttt ggt aaa here etc 307 Val Thr Ala Val Val Asp Thr Leu Leu Asp Gly Phe Gly Lys Thr Leu 55 60 65 gcc tcg gtc gcc cta ttg gta ggc ctg ggt gcc atg ctt ggt cga ttg 355 10 Ala Ser Val Ala Leu Leu Val Gly Leu Gly Ala Met Leu Gly Arg Leu 70 75 80 85 gtt gaa here tcc ggt ggc gca aaa tet cta gcc gac act atg gtg cga 403 Val Glu Thr Ser Gly Gly Wing Lys Ser Leu Wing Asp Thr Met Val Arg • 90 95 100 ate ttc ggt gaa aaa cga gca gct tcc gca etc ggt gtc gca tcg ctg 451 He Phe Gly Glu Lys Arg Ala Ala Phe Ala Leu Gly Val Ala Ser Leu 105 110 115 ate atg gga ttc cct ate ttc ttc gat gct ggc etc gtg gtc atg etc 499 He Met Gly Phe Pro He Phe Phe Asp Wing Gly Leu Val Val Met Leu 120 125 130 cca gtg ate ttc gca gta gct cga cgc etc aac ggc tcc gtc ctt act 547 15 Pro Val He Phe Wing Val Wing Arg Arg Leu Asn Gly Ser Val Leu Thr 135 140 145 ttt ggt ate cct gca gct gcc gcc ttc tet gtc atg fall gtg ttc gtc 595 Phe Gly He Pro Wing Wing Gly Wing Phe Ser Val Met His Val Phe Val 150 155 160 165 cca cct cca cca ggc cca att gca gcc tet gaa ttc ttc ggc gca caa 643 Pro Pro His Pro Gly Pro He Wing Wing Ser Glu Phe Phe Gly Wing Gln 170 175 180 gtt gga tac gta cta ate gct ggc ate ate gtt gca cta ccc acc tgg 691 Val Gly Tyr Val Leu He Wing Gly He He Val Wing Leu Pro Thr Trp 185 190 195 tat tta acc ggt tac ctg cta ggt aag ttc tta ggc cga aag ttc ccc 739 20 Tyr Leu Thr Gly Tyr Leu Leu Gly Lys Phe Leu Gly Arg Lys Phe Pro 200 205 210 ctt ccc gta ccc gat cta etc agt ggt gga gca cag gaa gat gat cag 787 Leu Pro Val Pro Asp Leu Leu Ser Gly Gly Wing Gln Glu Asp Asp Gln 215 220 225 cct cag aac cca gct aac gca gtg tcg ate att gtc att ttg etc att 835 Pro Gln Asn Pro Wing Asn Wing Val Ser He He Val He Leu Leu He 230 235 240 245 cct atg etc ctt att ttt ggc aat acc gga here tca atg gca gtt tcc 883 Pro Met Leu Leu He Phe Gly Asn Thr Gly Thr Ser Met Wing Val Ser 250 255 260 gcc ggc etc cta gat gca gaa tcc acc atg gtg aaa att cta gga ttc 931 25 Wing Gly Leu Leu Asp Wing Glu Being Thr Met Val Lys He Leu Gly Phe ^ ía í l ^? t ^ 265 270 275 etc ggc gaa here cca gtg gca ctg etc att acc ttg ate att gcc ctg 979 Leu Gly Glu Thr Pro Val Wing Leu Leu He Thr Leu He He Wing Wing Leu 280 285 290 ttc tcc cta ggc aac cga cgt ggc att aat ggt tet gct cta gag aaa 1027 Phe Phe Leu Gly Asn Arg Arg Gly He Asn Gly Be Ala Leu Glu Lys 295 300 305 acc ate gaa ggc gcac gcc cca ate tgt tca gtc gta tta ate act 1075 Thr He Glu Gly Wing Leu Gly Pro He Cys Ser Val Val Leu He Thr 310 315 320 325 ggc gcc ggt ggc atg ttc ggt gga gtg cta cgc acg tet gga att gga 1123 Gly Wing Gly Gly Met Phe Gly Gly Val Leu Arg Thr Ser Gly He Gly 330 335 340 gga gcg ctt gca gac tcc atg gca gat cta gga ctt cca gtt ate gca 1171 Gly Ala Leu Ala Asp Ser Met Wing Asp Leu Gly Leu Pro Val He Wing 345 350 355 ggt tgt ttc ate gtg gca gcc gtc ctt cgt gtc gcg cag ggt tet gcc 1219 Gly Cys Phe He Val Wing Wing Val Leu Arg Val Wing Gln Gly Ser Wing 360 365 370 acc gtt gcg cta acc acc gcc gca gca etc atg gca cct gct gtt gcc 1267 10 Thr Val Wing Leu Thr Thr Wing Wing Wing Leu Wing Wing Pro Wing Wing 375 380 385 gct gct gac ttt aac gaa ttc cag ctt gct gcc tet gtt att tcc act 1315 Wing Wing Asp Phe Asn Glu Phe Gln Leu Wing Wing Val He Ser Thr • 390 395 400 405 gcc ggt tet gtt att gcc age falls gtc aac gac tcc gga ttc tgg 1363 Wing Wing Gly Ser Val He Wing Ser His Val Asn Asp Ser Gly Phe Trp 410 415 420 etc gtt ggt cga etc atg aac gcc gac gta ccc acc acg cta aaa act 1411 Leu Val Gly Arg Leu Met Asn Wing Asp Val Pro Thr Thr Leu Lys Thr 425 430 435 tgg acc gta aac gtg gtg att gtg gt gt gtg atg gcc 1459 15 Trp Thr Val Asn Gln Thr Cys He Wing He Val Gly Phe Val Met Wing 440 445 450 tat gca atg ttc gga ttg gca tcg ctt gca tagt: ccgctg atccccattga 1509 Tyr Wing Met Phe Gly Leu Wing Ser Leu Wing 455 460 ttc 1512 < 210 > 630 < 211 > 463 • < 212 > PRT < 213 > CC rynebact: erium glutamicum 20 < 400 > 630 Met Asp Thr Trp Glu Gln Thr Leu Gly Thr Gly Pro Leu Leu Gly He 1 5 10 15 Ala Ala Gly Ala He Ala Ala Leu He Leu Val Leu Val He Val Phe Lys 20 25 30 Leu His Ala Phe Leu Thr Leu He Leu Val Ser He Val Thr Ala Leu 35 40 45 Ala Ala Gly He Pro Val Thr Ala Val Val Asp Thr Leu Leu Asp Gly 50 55 60 Phe Gly Lys Thr Leu Ala Ser Val Ala Leu Leu Val Gly Leu Gly Ala 65 70 75 80 Met Leu Gly Arg Leu Val Glu Thr Ser Gly Gly Wing Lys Ser Leu Wing 25 85 90 95 Asp Thr Met Val Arg He Phe Gly Glu Lys Arg Ala Wing Phe Wing Leu 100 105 110 Gly Val Wing Being Leu He Met Gly Phe Pro He Phe Phe Asp Wing Gly 115 120 125 Leu Val Val Met Leu Pro Val He Phe Wing Val Wing Arg Arg Leu Asn 130 135 140 Gly Ser Val Leu Thr Phe Gly He Pro Wing Wing Gly Wing Phe Ser Val 145 150 155 160 Met His Val Phe Val Pro Pro His Pro Gly Pro He Wing Wing Ser Glu WP 165 170 175 Phe Phe Gly Wing Gln Val Gly Tyr Val Leu He Wing Gly He He Val 180 185 190 Wing Leu Pro Thr Trp Tyr Leu Thr Gly Tyr Leu Leu Gly Lys Phe Leu 195 200 205 G and Arg Lys Phe Pro Leu Pro Val Pro Asp Leu Leu Ser Gly Gly Wing 210 215 220 Gln Glu Asp Asp Gln Pro Gln Asn Pro Wing Asn Wing Val Ser He He 225 230 235 240 Val He Leu Leu He Pro Met Leu Leu He Phe Gly Asn Thr Gly Thr 245 250 255 10 Ser Met Wing Val Being Wing Gly Leu Leu Asp Wing Glu Being Thr Met Val 260 265 270 Lys He Leu Gly Phe Leu Gly Glu Thr Pro Val Wing Leu Leu He Thr 275 280 285 • Leu He He Ala Leu Phe Phe Leu Gly Asn Arg Arg Gly He Asn Gly 290 295 300 Be Ala Leu Glu Lys Thr He Glu Gly Ala Leu Gly Pro He Cys Ser 305 310 315 320 Val Val Leu He Thr Gly Wing Gly Gly Met Phe Gly Gly Val Leu Arg 325 330 335 Thr Be Gly He Gly Gly Ala Leu Wing Asp Ser Met Wing Asp Leu Gly 340 345 350 15 Leu Pro Val He Wing Gly Cys Phe He Val Wing Wing Val Leu Arg Val 355 360 365 Wing Gln Gly Ser Wing Thr Val Wing Leu Thr Thr Wing Ala Ala Leu Met 370 375 380 Wing Pro Ala Wing Wing Ala Wing Asp Phe Asn Glu Phe Gln Leu Wing Wing 385 390 395 400 He Val He Ser Thr Wing Wing Gly Ser Val He Wing His Val Asn 405 410 415 Asp Ser Gly Phe Trp Leu Val Gly Arg Leu Met Asn Wing Asp Val Pro • 420 425 430 Thr Thr Leu Lys Thr Trp Thr Val Asn Gln Thr Cys He Wing He Val 435 440 445 20 Gly Phe Val Met Wing Ala Tyr Wing Met Phe Gly Leu Ala Ser Leu Ala 450 455 460 <; 210 > 631 < 211 > 1608 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1585) < 223 > RXN00432 25 - ^ - í ...- * JL < á * < 400 > 631 agctaatietg, ccttgcttta cacctccggg ct, ataacaat ccagtgc, cag tggctaggga 60 tttactaaaa, atcgggtaac aicgcgcgtaig tatttttcgc atg gaa tta ttg gag 115 Met Glu Leu Leu Glu 1 5 acc ttc ate act gat gtc att aat gac aat ttg tgg atg ate ttg ccc 163 Thr Phe He Thr Asp Val He Asn Asp Asn Leu Trp Met He Leu Pro 10 15 20 ttc ttg etc gtt gct gct gcc etc tat ttc ggt ggg cgt acg ttg ctg 211 Phe Leu Leu Val Wing Wing Gly Leu Tyr Phe Gly Gly Arg Thr Leu Leu 25 30 35 gtt cag att cgg atg att ccg gag atg ttc aaa gcg gtc gtc gag aag 259 Val Gln He Arg Met He Pro Glu Met Phe Lys Wing Val Val Glu Lys 40 45 50 cct gcg aag gat ggg gag ttc gcg gac aag cag gac att tcg gct ttt 307 Pro Ala Lys Asp Gly Glu Phe Wing Asp Lys Gln Asp He Ser Wing Phe 55 60 65 aag gcg ttc acg att tet gcg gcg tcg cga gtt ggt acg gcg aat gtt 355 Lys Wing Phe Thr He Ser Wing Wing Being Arg Val Gly Thr Wing Asn Val 70 75 80 85 10 gcg ggt gtt gcg ctg gcg ate act ctg ggt gga ccg ggt gca gtg ttc 403 Ala Gly Val Ala Leu Ala He Thr Leu Gly Gly Pro Gly Ala Val Phe 90 95 100 tgg atg tgg ate att gcg ctg gtt ggc ggt gcg here tcg ttc att gag 451 • Trp Met Trp He He Wing Leu Val Gly Gly Wing Thr Ser Phe He Glu 105 110 115 tcg act ctt gga cag ttg tgg aag gtg aag gac ggc gac age tat cgc 499 Be Thr Leu Gly Gln Leu Trp Lys Val Lys Asp Gly Asp Ser Tyr Arg 120 125 130 ggt ggc cct gcg tac tac atg acg ctt ggt ttg aat gct cgg tgg ctt 547 Gly Gly Pro Wing Tyr Tyr Met Thr Leu Gly Leu Asn Wing Arg Trp Leu 135 140 145 15 gcg gtt gtt ttc ggt gtc gcc ate acg ttg acc ttt ggt ttt gtg tac 595 Wing Val Val Phe Gly Val Wing He Thr Leu Thr Phe Gly Phe Val Tyr 150 155 160 165 aac gct ttg cag tcc aac gcg gtt gtt gag gcg att acg gta tca etc 643 Asn Ala Leu Gln Ser Asn Ala Val Val Glu Ala He Thr Val Ser Leu 170 175 180 ggc acc cct tet acc act gca aag gct ttt gtt ggc ttg ggc atg gct 691 Gly Thr Pro Ser Thr Thr Ala Lys Ala Phe Val Gly Leu Gly Met Ala 185 190 195 • gga ttg tet gcg ctg gtt att ttt ggc ggc gtg cag cgt ate gca aac 739 Gly Leu Be Wing Leu Val He Phe Gly Gly Val Gln Arg He Wing Asn 200 205 210 20 gtg acg cag tgg atg gtt ccg ttc atg gcg ggt gcg tac ate att gtg 787 Val Thr Gln Trp Met Val Pro Phe Met Wing Gly Wing Tyr He He Val 215 220 225 ggt gtg gtg att gtg att aac att cag cag gtt ccg acc atg ate 835 Gly Val Val Val He Val He Asn He Gln Gln Val Pro Thr Met He 230 235 240 245 aac gac ate att gct ggt gct ttt ggt ttc cgt ccg gtt gct act gcg 883 Asn Asp He He Wing Gly Wing Phe Gly Phe Arg Pro Val Wing Thr Wing 250 255 260 tcg gtg tgg ggc gcg ttc tgg ttg gcg ttt atg aac ggt atg cgc cgt 931 Ser Val Trp Gly Wing Phe Trp Leu Wing Phe Met Asn Gly Met Arg Arg 265 270 275 25 gga ctg ttc tcc aat gag gct ggt gag ggt tet gtc ccg aac gct gct 979 Gly Leu Phe Ser Asn Glu Wing Gly Glu Gly Ser Val Pro Asn Wing Ala 280 285 290 gct gcg ac gtg act gtg tet cct gtg aag cag ggt ttg gtt cag act 1027 Wing Thr Wing Thr Val Ser His Pro Val Lys Gln Gly Leu Val Gln Thr 295 300 305 ctg ggt gta tat ttc gac acc ctg etc gtt tgt age att acc gct ttt 1075 Leu Gly Val Tyr Phe Asp Thr Leu Leu Val Cys Ser He Thr Ala Phe 310 315 320 325 gtc ate ctg ctg tet gga gtg gag tac gcg acc ggc gat att cag tet 1123 Val He Leu Leu Ser Gly Val Glu Tyr Ala Thr Gly Asp He Gln Ser 330 335 340 tet tet ttg act tcg gcg ctg gct age gtt gtt ggt ggg ggg tgg gga 1171 Be Ser Leu Thr Gln Ser Ala Leu Ala Ser Val Val Gly Gly Trp Gly 345 350 355 acc fall ttc att acc gta gtg atg ttc ttc ctg gcg ttt tet tcc gtg 1219 Thr His Phe He Thr Val Val Met Phe Phe Leu Wing Phe Ser Ser Val 360 365 370 ctg ggt aac tac tac ttg gca cag gcg aat att cag tac ttc acc gat 1267 Leu Gly Asn Tyr Tyr Leu Wing Gln Wing Asn He Gln Tyr Phe Thr Asp 375 380 385 tcg aag act gtc atg act gtt ttc cga etc ttg gtg ctg etc age gtg 1315 Being Lys Thr Val Met Thr Val Phe Arg Leu Leu Val Leu Leu Ser Val 390 395 400 405 ttc tet ggc gcg gtt gct tcg gtg ccg ttg ate tgg gct ttg ggt gat 1363 Phe Ser Gly Wing Val Wing Ser Val Pro Leu He Trp Wing Leu Gly Asp 410 415 420 act ttc gct ggc ate atg gtg etc att aac ctg gcg gcg ate att ccg 1411 Thr Phe Wing Gly He Met Val Leu He Asn Leu Wing Wing He He Pro 425 430 435 ctg ggt ggc gtt gca gtg aag ttg ctt aag aat tac acc att cag aag 1459 Leu Gly Gly Val Wing Val Lys Leu Leu Lys Asn Tyr Thr He Gln Lys 440 445 450 aag gct ggt ctg gat cct gtg ttc falls cgc gac atg atg cca gag gtt 1507 Lys Wing Gly Leu Asp Pro Val Phe His Arg Asp Met Met Pro Glu Val 455 460 465 cgt aat att gcg tgc tgg aac ggc aaa gat gca gct here tcc aac tat 1555 Arg Asn He Wing Cys Trp Asn Gly Lys Asp Wing Wing Thr Ser Asn Tyr 470 475 480 485 falls gaa gcg atg gaa gtg ate aag aag age tagticatega aggaeicagtg 1605 His Glu Wing Met Glu Val He Lys Lys Ser 490 495 gta 1608 < 210 > 632 < 211 > 495 < 212 > PRT < 213 > Corynebact, erium glutamicum < 400 > 632 Met Glu Leu Leu Glu Thr Phe He Thr Asp Val He Asn Asp Asn Leu 1 5 10 15 Trp Met He Leu Pro Phe Leu Leu Val Wing Wing Gly Leu Tyr Phe Gly 20 25 30 Gly Arg Thr Leu Leu Val Gln He Arg Met He Pro Glu Met Phe Lys 35 40 45 Wing Val Val Glu Lys Pro Wing Lys Asp Gly Glu Phe Wing Asp Lys Gln 50 55 60 ttt J?. ?? .abtn.

Asp He Ser Ala Phe Lys Ala Phe Thr He Ser Ala Ala Ser Arg Val 65 70 75 80 Gly Thr Wing Asn Val Wing Gly Val Wing Leu Wing He Thr Leu Gly Gly 85 90 95 Pro Gly Wing Val Phe Trp Met Trp He He Wing Leu Val Gly Gly Wing 100 105 110 Thr Ser Phe He Glu Ser Thr Leu Gly Gln Leu Trp Lys Val Lys Asp 115 120 125 Gly Asp Ser Tyr Arg Gly Gly Pro Wing Tyr Tyr Met Thr Leu Gly Leu 130 135 140 Asn Ala Arg Trp Leu Ala Val Val Phe Gly Val Ala He Thr Leu Thr 145 150 155 160 Phe Gly Phe Val Tyr Asn Wing Leu Gln Ser Asn Wing Val Val Glu Wing 165 170 175 He Thr Val Ser Leu Gly Thr Pro Ser Thr Thr Ala Lys Ala Phe Val 180 185 190 Gly Leu Gly Met Wing Gly Leu Ser Wing Leu Val He Phe Gly Gly Val 195 200 205 Gln Arg He Wing Asn Val Thr Gln Trp Met Val Pro Phe Met Wing Gly 210 215 220 Wing Tyr He He Val Val Val Val Val He Val He Asn He Gln Gln 225 230 235 240 Val Pro Thr Met He Asn Asp He He Wing Gly Wing Phe Gly Phe Arg 245 250 255 Pro Val Ala Thr Ala Ser Val Trp Gly Ala Phe Trp Leu Ala Phe Met 260 265 270 Asn Gly Met Arg Arg Gly Leu Phe Ser Asn Glu Wing Gly Glu Gly Ser 275 280 285 Val Pro Asn Ala Ala Ala Thr Ala Thr Val Ser His Pro Val Lys Gln 290 295 300 Gly Leu Val Gln Thr Leu Gly Val Tyr Phe Asp Thr Leu Leu Val Cys 305 310 315 320 Ser He Thr Wing Phe Val He Leu Leu Ser Gly Val Glu Tyr Ala Thr 325 330 335 Gly Asp He Gln Being Ser Leu Thr Gln Being Ala Leu Ala Ser Val 340 345 350 Val Gly Gly Trp Gly Thr His Phe He Thr Val Val Met Phe Phe Leu 355 360 365 Wing Phe Ser Ser Val Leu Gly Asn Tyr Tyr Leu Wing Gln Wing Asn He 370 375 380 Gln Tyr Phe Thr Asp Ser Lys Thr Val Met Thr Val Phe Arg Leu Leu 385 390 395 400 Val Leu Leu Ser Val Phe Ser Gly Ala Val Ala Ser Val Pro Leu He 405 410 415 TrP Wing Leu Gly Asp Thr Phe Wing Gly He Met Val Leu He Asn Leu 420 425 430 Wing Wing He Pro Pro Leu Gly Val Val Wing Lys Leu Leu Lys Asn 435 440 445 Tyr Thr He Gln Lys Lys Wing Gly Leu Asp Pro Val Phe His Arg Asp 450 455 460 Met Met Pro Glu Val Arg Asn He Wing Cys Trp Asn Gly Lys Asp Ala 465 470 475 480 Wing Thr Ser Asn Tyr His Glu Wing Met Glu Val He Lys Lys Ser 485 490 495 < 210 > 633 < 211 > 914 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (891) < 223 > FRXA00432 < 400 > 633 ttg tet gcg ctg gtt att ttt ggc ggc gtg cag cgt ate gca aac gtg 48 Leu Ser Ala Leu Val He Phe Gly Gly Val Gln Arg He Ala Asn Val 1 5 10 15 acg cag tgg atg gtt ccg ttc atg gcg ggt gcg tac ate att gtg ggt 96 Thr Gln Trp Met Val Pro Phe Met Wing Gly Wing Tyr He He Val Gly 20 25 30 gtg gtg gtg att gtg att aac att cag gtt ccg acc atg ate aac 144 Val Val Val He Val He Asn He Gln Gln Val Pro Thr Met He Asn 35 40 45 gac ate att gct ggt gct ttt ggt ttc cgt ccg gtt gct act gcg tcg 192 Asp He He Wing Gly Wing Phe Gly Phe Arg Pro Val Wing Thr Wing Being 10 50 55 60 gtg tgg ggc gcg ttc tgg ttg gcg ttt atg aac ggt atg cgc cgt gga 240 Val Trp Gly Wing Phe Trp Leu Wing Phe Met Asn Gly Met Arg Arg Gly 65 70 75 80 ctg ttc tcc aat gag gct gag ggt tet gtc ccg aac gct gct gct 288 • ggt Leu Phe Ser Asn Glu Wing Gly Glu Gly Ser Val Pro Asn Ala Wing Wing 85 90 95 gcg act gtg tet falls cct gtg aag cag ggt ttg gtt cag act ctg 336 Thr Ala Thr Val Ser His Pro Val Lys Gln Gly Leu Val Gln Thr Leu 100 105 110 ggc gta tat ttc gac acc ctg etc gtt tgt age att acc gct ttt gtc 384 Gly Val Tyr Phe Asp Thr Leu Leu Val Cys Ser He Thr Wing Phe Val 15 115 120 125 ate ctg ctg tet gga gtg gag tac gcg acc ggc gat att cag tet tet 432 He Leu Leu Ser Gly Val Glu Tyr Ala Thr Gly Asp He Gln Ser Ser 130 135 140 tet ttg act tcg gcg ctg gct age gtt gtt ggt ggt tgg gga acc 480 Be Leu Thr Gln Be Ala Leu Ala Be Val Val Gly Gly Trp Gly Thr 145 150 155 160 fall ttc att acc gta gtg atg ttc ttc ctg gcg ttt tet tcc gtg ctg 528 His Phe He Thr Val Val Met Phe Phe Leu Ala Phe Ser Ser Val Leu • 165 170 175 ggt aac tac tac ttg gca cag gcg aat att cag tac ttc acc gat tcg 576 Gly Asn Tyr Tyr Leu Wing Gln Wing Asn He Gln Tyr Phe Thr Asp Ser 20 180 185 190 aag act gtc atg act gtt ttc cga etc ttg gtg ctg etc age gtg ttc 624 Lys Thr Val Met Thr Val Phe Arg Leu Leu Val Leu Leu Ser Val Phe 195 200 205 tet ggc gcg gtt gct tcg gtg ccg ttg ate tgg gct ttg ggt gat act 672 Ser Gly Wing Val Wing Ser Val Pro Leu He Trp Wing Leu Gly Asp Thr 210 215 220 ttc gct ggc ate atg gtg etc att aac ctg gcg gcg ate att ccg ctg 720 Phe Ala Gly He Met Val Leu He Asn Leu Ala Ala He He Pro Leu 225 230 235 240 ggt ggc gtt gca gtg aag ttg ctt aag aat tac acc att cag aag aag 768 Gly Gly Val Wing Val Lys Leu Leu Lys Asn Tyr Thr He Gln Lys Lys 25 245 250 255 - to?. ... gct ggt ctg gat cct gtg ttc falls cgc gac atg atg cca gag gtt cgt 816 Wing Gly Leu Asp Pro Val Phe His Arg Asp Met Met Pro Glu Val Arg 260 265 270 aat att gcg tgc tgg aac ggc aaa gat gca gct here tcc aac tat cae 864 Asn He Wing Cys Trp Asn Gly Lys Asp Wing Wing Thr Ser Asn Tyr His 275 280 285 gaa gcg atg gaa gtg ate aag aag age tagtcatega aggaacagtg 911 Glu Ala Met Glu Val He Lys Lys Ser 290 295 • gta 914 < 210 > 634 < 211 > 297 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 634 Leu Be Ala Leu Val He Phe Gly Gly Val Gln Arg He Wing Asn Val 1 5 10 15 Thr Gln Trp Met Val Pro Phe Met Wing Gly Wing Tyr He He Val Vally 10 20 25 30 Val Val Val He Val He Asn He Gln Gln Val Pro Thr Met He Asn 35 40 45 Asp He He Wing Gly Wing Phe Gly Phe Arg Pro Val Wing Thr Wing Being • 50 55 60 Val Trp Gly Wing Phe Trp Leu Wing Phe Met Asn Gly Met Arg Arg Gly 65 70 75 80 Leu Phe Ser Asn Glu Wing Gly Glu Gly Ser Val Pro Asn Wing Wing 85 90 95 Thr Wing Thr Val Ser His Pro Val Lys Gln Gly Leu Val Gln Thr Leu 100 105 110 Gly Val Tyr Phe Asp Thr Leu Leu Val Cys Ser He Thr Ala Phe Val 15 115 120 125 He Leu Leu Ser Gly Val Glu Tyr Ala Thr Gly Asp He Gln Ser Ser 130 135 140 Ser Leu Thr Gln Ser Ala Leu Ala Ser Val Val Gly Gly Trp Gly Thr 145 150 155 160 His Phe He Thr Val Val Met Phe Phe Leu Wing Phe Ser Val Leu 165 170 175 Gly Asn Tyr Tyr Leu Wing Gln Wing Asn He Gln Tyr Phe Thr Asp Ser 180 185 190 • Lys Thr Val Met Thr Val Phe Arg Leu Leu Val Leu Leu Ser Val Phe 195 2 00 205 Ser Gly Ala Val Ala Ser Val Pro Leu He Trp Ala Leu Gly Asp Thr 20 210 215 220 Phe Ala Gly He Met Val Leu He Asn Leu Ala Ala He He Pro Leu 225 230 235 240 Gly Val Val Val Leys Leu Leu Lys Asn Tyr Thr He Gln Lys Lys 245 250 255 Wing Gly Leu Asp Pro Val Phe His Arg Asp Met Met Pro Glu Val Arg 260 265 270 Asn He Wing Cys Trp Asn Gly Lys Asp Ala Wing Thr Ser Asn Tyr His 275 280 285 Glu Wing Met Glu Val He Lys Lys Ser 290 295 25 < 210 > 635 < 211 > 569 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (45) .. (569) < 223 > FRXA00436 5 < 400 > 635 gggatttact aaaaatcggg taacacgcgc gtagtatttt tcgc atg gaa tta ttg 56 Met Glu Leu Leu 1 gag acc ttc ate act gat gtc att aat gac aat ttg tgg atg ate ttg 104 Glu Thr Phe He Thr Asp Val As Asn Asn Leu Trp Met He Leu 5 10 15 20 ccc ttc ttg etc gtt gct gct ggc etc tat ttc ggt ggg cgt acg ttg 152 Pro Phe Leu Leu Val Wing Wing Gly Leu Tyr Phe Gly Gly Arg Thr Leu 25 30 35 ctg gtt cag att cgg atg att ccg gag atg ttc aaa gcg gtc gtc gag 200 10 Leu Val Gln He Arg Met He Pro Glu Met Phe Lys Wing Val Val Glu 40 45 50 aag cct gcg aag gat ggg gag ttc gcg gac aag cag gac att tcg gct 248 Lys Pro Wing Lys Asp Gly Glu Phe Wing Asp Lys Gln Asp He Ser Wing • 55 60 65 ttt aag gcg ttc acg att tet gcg gcg tcg cga gtt ggt acg gcg aat 296 Phe Lys Wing Phe Thr He Ser Wing Wing Being Arg Val Gly Thr Wing Asn 70 75 80 gtt gcg ggt gtt gcg ctg gcg ate act ctg ggt gga ccg ggt gca gtg 344 Val Ala Gly Val Ala Leu Ala He Thr Leu Gly Gly Pro Gly Ala Val 85 90 95 100 ttc tgg atg tgg ate att gcg ctg gtt ggc ggt gcg here tcg ttc att 392 15 Phe Trp Met Trp He He Wing Wing Leu Val Gly Gly Wing Thr Ser Phe He 105 110 115 gag tcg act ctt gga cag ttg tgg aag gtg aag gac ggc gac age tat 440 Glu Ser Thr Leu Gly Gln Leu Trp Lys Val Lys Asp Gly Asp Ser Tyr 120 125 130 cgc ggt ggc cct gcg tac tac atg acg ctt ggt ttg aat gct cgg tgg 488 Arg Gly Gly Pro Wing Tyr Tyr Met Thr Leu Gly Leu Asn Wing Arg Trp 135 140 145 ctt gcg gtt gtt ttc ggt gtc gcc ate acg ttg acc ttt ggt ttt gtg 536 • Leu Ala Val Val Phe Gly Val Ala He Thr Leu Thr Phe Gly Phe Val 150 155 160 tac aac gct ttg cag tcc aac gcg gtt gtt gag 569 2nd Tyr Asn Ala Leu Gln Ser Asn Ala Val Val Glu 165 170 175 < 210 > 636 < 211 > 175 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 636 Met Glu Leu Leu Glu Thr Phe He Thr Asp Val He Asn Asp Asn Leu 1 5 10 15 Trp Met He Leu Pro Phe Leu Leu Val Wing Wing Gly Leu Tyr Phe Gly 25 20 25 30 Gly Arg Thr Leu Leu Val Gln He Arg Met He Pro Glu Met Phe Lys 35 40 45 Wing Val Val Glu Lys Pro Wing Lys Asp Gly Glu Phe Wing Asp Lys Gln 50 55 60 Asp He Ser Wing Phe Lys Wing Phe Thr He Ser Wing Wing Ser Arg Val 65 70 75 80 Gly Thr Ala Asn Val Ala Gly Val Ala Leu Ala He Thr Leu Gly Gly 85 90 95 Pro Gly Wing Val Phe Trp Met Trp He Wing Wing Leu Val Gly Gly Wing 100 105 110 Thr Ser Phe He Glu Ser Thr Leu Gly Gln Leu Trp Lys Val Lys Asp 115 120 125 Gly Asp Ser Tyr Arg Gly Gly Pro Wing Tyr Tyr Met Thr Leu Gly Leu 130 135 140 Asn Wing Arg Trp Leu Wing Val Val Phe Gly Val Wing He Thr Leu Thr 145 150 155 160 Phe Gly Phe Val Tyr Asn Ala Leu Gln Ser Asn Ala Val Val Glu 165 170 175 < 210 > 637 < 211 > 1572 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1549) < 223 > RXA00847 < 400 > 637 tctggcccgc tgtgtcctct ggacgcagcg ggccagtagt attttggggg tgagaataag 60 gtttggaatt ctaagtgttg tcgcctgcac ggtttcgttg gtg gca tgt cag gct 115 Val Wing Cys Gln Wing 1 5 aat ccg ggt cct gcg ccc gtt gag gag cca act gcc act gcg acg 163 Asn Pro Gly Pro Pro Wing Val Glu Glu Pro Thr Thr Wing Thr Wing Thr 10 15 20 acc acg gca act gag acg ac acc gta gag act gaa gcc ccc aaa caa 211 Thr Thr Wing Thr Glu Thr Thr Thr Val Glu Thr Glu Ala Pro Lys Gln 25 30 35 gat cgg gaa acc ate agt att ggt ate gat cc g ate c gc aac ggt ttc 259 Asp Arg Glu Thr He Ser He Gly He Asp Pro He Arg Asn Gly Phe 40 45 50 aat cca cat ttg ttg tet gat gat tet cca ctg gtg cgc gat act gca 307 Asn Pro His Leu Leu Ser Asp Asp Ser Pro Leu Val Arg Asp Thr Ala 55 60 65 tcg ttg gtg ttg ccg agt gct ttt gag ggc aat cag ctg aac act gac 355 Be Leu Val Leu Pro Be Wing Phe Glu Gly Asn Gln Leu Asn Thr Asp 70 75 80 85 ttg ttg gac aat gtt gag cag gtg gat gaa acc acg gtg agg tac acg 403 Leu Leu Asp Asn Val Glu Gln Val Asp Glu Thr Thr Val Arg Tyr Thr 90 95 100 att gct cag gaa gcg cag tgg agt gat ggc act ccg att act ggg tet 451 He Wing Gln Glu Wing Gln Trp Ser Asp Gly Thr Pro He Thr Gly Ser 105 110 115 gat ttt gag tac tgc agg tcc att gtg gcg ggg here gga acg ctg 499 Asp Phe Glu Tyr Leu Arg Arg Ser He Val Wing Gly Thr Gly Thr Leu ^ jj ^ y ^^^ jj 120 125 130 aac gat tet gca tat tcg gcg att tca gag att agg acc tca ggc ggt 547 Asn Asp Be Wing Tyr Be Wing Be Ser Glu He Arg Thr Ser Gly Gly 135 140 145 gga aaa act gtc gac gtt att ttt gaa cat cct gtc gct gat tgg cat 595 Gly Lys Thr Val Asp Val He Phe Glu His Pro Val Wing Asp Trp His 150 155 160 165 ttg ctg ttt aac aat ttg ttg ccg agt cat ttg ate act ggc aat tcc 643 Leu Leu Phe Asn Asn Leu Leu Pro Ser His Leu He Thr Gly Asn Ser • 170 175 180 here tcc cag here gcg ttt tat gat tcc ate ccg gcc tet gcg gggcgc 691 Thr Phe Gln Thr Wing Phe Tyr Asp Ser He Pro Wing Wing Wing Gly Arg 185 190 195 tac atg gtg cgt tcc att gat cgt cag cgc ggc gtg att acg ttg tcg 739 Tyr Met Val Arg Ser He Asp Arg Gln Arg Gly Val He Thr Leu Ser 200 205 210 cgc aat gat cgt ttc tgg ggt gca aat ccg gca falls gtg gaa gta etc 787 Arg Asn Asp Arg Phe Trp Gly Wing Asn Pro Wing His Val Glu Val Leu 215 220 225 caa ttc aac gtt gcc tetc gcc tcc cgg cgg ggg gag tac cgc cgc 835 10 Gln Phe Asn Thr Val Wing Being Wing Being Arg Wing Gly Glu Tyr Leu Arg 230 235 240 245 acc ggg cag agt tcg ttt atg aat ctg tca ccg cag gaa acc ctg gtg 883 Thr Gly Gln Being Being Phe Met Asn Leu Being Pro Gln Glu Thr Leu Val 250 255 260 gac acg ttg aat ttg gtg ccg gac acg gaa gtg cgg gtg tet gac acg 931 Asp Thr Leu Asn Leu Val Pro Asp Thr Glu Val Arg Val Ser Asp Thr 265 270 275 acg cgc acg ctg gag ctg gta ttc aac gcc gaa gcg ctg gca ccg gcg 979 Thr Arg Thr Leu Glu Leu Val Phe Asn Wing Glu Wing Leu Wing Pro Wing 280 285 290 cag cgc gcc tac ctg here tcg ctt ate gac gtc ccc etc acc gcc aag 1027 15 Gln Arg Ala Tyr Leu Thr Ser Leu He Asp Val Pro Leu Thr Ala Lys 295 300 305 tta gct ggc ggt cgc agt gca aac ctg ggt gtg ccc caa acg gtg gag 1075 Leu Wing Gly Gly Arg Wing Asn Leu Gly Val Pro Gln Thr Val Glu 310 315 320 325 gcg age gtc gat aag caa gaa att cct gcg ttg cgc ctg gcg gcg gac 1123 Wing Ser Val Asp Lys Gln Glu He Pro Wing Leu Arg Leu Wing Wing Asp 330 335 340 ccc gcc gac gat gct ggt ttg gca gct gcg cgg ggc ate gtc gat atg 1171 • Pro Wing Asp Asp Wing Gly Leu Wing Wing Wing Arg Gly He Val Asp Met 345 350 355 ctg gct gcg gat gga ate aag gct cag gtc gtg ac tta ttg aat 1219 20 Leu Wing Wing Asp Gly He Lys Wing Gln Val Val Thr Thr Asp Leu Asn 360 365 370 tcg gcg att gcg ggt aat ttt gat gcg ate gtg gcg tgg acc aga act 1267 Be Ala Wing Wing Gly Asn Phe Asp Wing He Val Wing Trp Thr Arg Thr 375 380 385 gcc acg gat tcg att gcg ttg gcg gac cga gtg ggt tgt ggc gtg aac 1315 Wing Thr Asp Ser Wing Wing Leu Wing Asp Arg Val Gly Cys Gly Val Asn 390 395 400 405 ttg gca aag tgg tgc gct gag gga acc acg gaa tat ate aac ggt gtt 1363 Leu Wing Lys Trp Cys Wing Glu Gly Thr Thr Glu Tyr He Asn Gly Val 410 415 420 ttg gcg ggt gag att gat ttc gat cct gcg tgg gag cag ttt aac 1411 25 Leu Wing Gly Glu He Asp Phe Asp Pro Wing Trp Glu Gln Gln Phe Asn 425 430 435 acc gag aat falls ttg cgg gtt ccg ate ctg cgg gag act cgg gta gaa 1459 Thr Glu Asn His Leu Arg Val Pro He Leu Arg Glu Thr Arg Val Glu 440 445 450 gcg aaa aat aac ggt ate etc ggg gct gcg gat ggc tgg cct ggg gga 1507 Wing Lys Asn Asn Gly He Leu Gly Wing Wing Asp Gly Trp Pro Gly Gly 455 '460 465 att tca agt gct gca agt tgg agg aaa aac gat gtt gaa gaa 1549 I Ser Ser Ala Ala Ser Trp Arg Lys Asn Asp Val Glu Glu • 470 475 480 tgatctgtct ggtgctcgag ttg 1572 < 210 > 638 < 211 > 483 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 638 Val Wing Cys Gln Wing Asn Pro Gly Pro Wing Pro Val Glu Glu Pro Thr 1 5 10 15 10 Thr Wing Thr Wing Thr Thr Thr Wing Thr Thr Glu Thr Thr Thr Val Glu Thr 20 25 30 Glu Wing Pro Lys Gln Asp Arg Glu Thr He Be He Gly He Asp Pro 35 40 45 He Arg Asn Gly Phe Asn Pro His Leu Leu As Asp Asp Ser Pro Leu 50 55 60 Val Arg Asp Thr Ala Ser Leu Val Leu Pro Be Ala Phe Glu Gly Asn 65 70 75 80 Gln Leu Asn Thr Asp Leu Leu Asp Asn Val Glu Gln Val Asp Glu Thr 85 90 95 Thr Val Arg Tyr Thr He Wing Gln Glu Wing Gln Trp Ser Asp Gly Thr 100 105 110 15 Pro He Thr Gly Ser Asp Phe Glu Tyr Leu Arg Arg Ser He Val Wing 115 120 125 Gly Thr Gly Thr Leu Asn Asp Being Wing Tyr Being Wing He Ser Glu He 130 135 140 Arg Thr Ser Gly Gly Gly Lys Thr Val Asp Val He Phe Glu His Pro 145 150 155 160 Val Wing Asp Trp His Leu Leu Phe Asn Asn Leu Pro Ser His Leu 165 170 175 He Thr Gly Asn Ser Thr Phe Gln Thr Wing Phe Tyr Asp Ser He Pro • 180 185 190 Wing Being Wing Gly Arg Tyr Met Val Arg Ser He Asp Arg Gln Arg Gly 195 200 205 20 Val He Thr Leu Ser Arg Asn Asp Arg Phe Trp Gly Wing Asn Pro Wing 210 215 220 His Val Glu Val Leu Gln Phe Asn Thr Val Wing Ser Wing Being Arg Wing 225 230 235 240 Gly Glu Tyr Leu Arg Thr Gly Gln Being Ser Phe Met Asn Leu Ser Pro 245 250 255 Gln Glu Thr Leu Val Asp Thr Leu Asn Leu Val Pro Asp Thr Glu Val 260 265 270 Arg Val Ser Asp Thr Thr Arg Thr Leu Glu Leu Val Phe Asn Wing Glu 275 280 285 Wing Leu Wing Pro Wing Gln Arg Wing Tyr Leu Thr Ser Leu He Asp Val 290 295 300 25 Pro Leu Thr Ala Lys Leu Ala Gly Gly Arg Ser Ala Asn Leu Gly Val 305 310 315 320 Pro Gln Thr Val Glu Ala Ser Val Asp Lys Gln Glu He Pro Ala Leu 325 330 335 Arg Leu Wing Wing Asp Pro Wing Asp Asp Wing Gly Leu Wing Wing Wing Arg 340 345 350 Gly He Val Asp Met Leu Wing Wing Asp Gly He Lys Wing Gln Val Val 355 360 365 Thr Thr Asp Leu Asn Ser Wing Wing Gly Asn Phe Asp Wing He Val 370 375 380 • Wing Trp Thr Arg Thr Wing Thr Asp Ser Wing Wing Leu Wing Asp Arg Val 385 390 395 400 Gly Cys Gly Val Asn Leu Wing Lys Trp Cys Wing Glu Gly Thr Thr Glu 405 410 415 Tyr He Asn Gly Val Leu Wing Gly Glu He Asp Phe Asp Pro Wing Trp 420 425 430 Glu Gln Gln Phe Asn Thr Glu Asn His Leu Arg Val Pro He Leu Arg 435 440 445 Glu Thr Arg Val Glu Wing Lys Asn Asn Gly He Leu Gly Wing Wing Asp 450 455 460 Gly Trp Pro Gly Gly He Ser Ser Wing Wing Ser Trp Arg Lys Asn Asp 10 465 470 475 480 Val Glu Glu < 210 > 639 • < 211 > 1192 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1192) < 223 > RXN01382 15 aaatggatgta < cctcatgagc accaegatta ctt; gccgcaa tttcctccga gcaaceggaa 60 tcctcggtgt < cgcagctggc atcggcgcaa cat? ttgctgc atg tgc acc aac aac 115 Met Cys Thr Asn Asn 1 5 acc ggc acc gga gcc tcc action acc gca gct ggc acc gga act gca 163 Thr Gly Thr Ser Gly Ser Thr Ser Thr Wing Wing Gly Thr Gly Thr Wing 10 15 20 • aat gaa ggc acc ate acc gca gcc ate tcc tac gaa ctg gga acc 211 Asn Glu Glu Gly Thr He Thr Wing Ala He Ser Tyr Glu Leu Gly Thr 25 30 35 20 aac ggc tac gac cca atg acc acc acc tcg gct etc act gtg gca gcc 259 Asn Gly Tyr Asp Pro Met Thr Thr Thr Ser Wing Leu Thr Val Wing Wing 40 45 50 aac tgg falls acc ctt gaa ggc etc acc gaa ate gac ccc gcc acc ggc 307 Asn Trp His Thr Leu Glu Gly Leu Thr Glu He Asp Pro Wing Thr Gly 55 60 65 gag gtc tac gca gca etc gcc age gca ctg cct tc gcc gat gcg acc 355 Glu Val Tyr Ala Ala Leu Ala Ser Ala Leu Pro Ser Ala Asp Ala Thr 70 75 80 85 tcc cta gac ate aag ctt cgc gac ggc gcc acc ttc falls aac ggc gac 403 Ser Leu Asp He Lys Leu Arg Asp Gly Wing Thr Phe His Asn Gly Asp 90 95 100 25 gca gtc acc gca gac gac gta gtc ttc tet ttt gag cga gtc etc gat 451 Wing Val Thr Wing Asp Asp Val Val Phe Ser Phe Glu Arg Val Leu Asp 105 110 115 cca gcc aac aac tcc ctt tac gca tcc tcc ate cca ttc ate aag tca 499 Pro Ala Asn Asn Ser Leu Tyr Ala Ser Phe He Pro Phe He Lys Ser 120 125 130 gtc acc aag aag gat gac acc acc gtc acc ate gac etc gac tac gca 547 Val Thr Lys Lys Asp Asp Thr Thr Val Thr He Asp Leu Asp Tyr Wing 135 140 145 acc ggc ate ate age gaa cgc etc gca gta gta aag ate gtg cca aag 595 Thr Gly He He Ser Glu Arg Leu Wing Val Val Lys He Val Pro Lys 150 155 160 165 tcc gtc gtg gaa gca gac gca tcc gga ttc gac gcc aac cca ate ggc 643 Ser Val Val Glu Ala Asp Wing Ser Gly Phe Asp Wing Asn Pro He Gly 170 175 180 tcc ggc cca tac aag atg acc gac aac ggt gca tcc aag gtg gtc aag 691 Ser Gly Pro Tyr Lys Met Thr Asp Asn Gly Wing Ser Lys Val Val Lys 185 190 195 ttc gag cgc aac gac gac tac aac ggc cca cgc cca gca cgt gcc gcc 739 phe glu arg asn asp asp tyr asn gly pro arg pro ala arg ala ala 200 205 210 aag atg gaa tgg cag ate ate ccc gac gcc tcc acc cgc acc aac tcc 787 Lys Met Glu Trp Gln He He Pro Asp Wing Ser Thr Arg Thr Asn Ser 215 220 225 ctt cag tcc ggc age acc atg gcc ate gac tcc gtt cca tac ctg teg 835 Leu Gln Ser Gly Ser Thr Met Ala He Asp Ser Val Pro Tyr Leu Ser 230 235 240 245 ate cca cag ctt gaa gcc acc age acc gta gaa tcc gtc caa gga ttc 883 He Pro Gln Leu Glu Wing Thr Ser Thr Val Glu Ser Val Gln Gly Phe 250 255 260 ggc etc ctg tcc gcc atg ttc age tgc tcc gaa ggc aac ccc ttc aac 931 Gly Leu Leu Phe Wing Met Phe Ser Cys Ser Glu Gly Asn Pro Phe Asn 265 270 275 gac gtc cgc aac cgc cag gca ttc etc tac gca ctg gac atg gac aag 979 Asp Val Arg Asn Arg Gln Wing Phe Leu Tyr Wing Leu Asp Met Asp Lys 280 285 290 Atta gtt aag acc ggc atg tcc gac cag gca acc cca gcc acc tcc ttc 1027 He Val Lys Thr Gly Met Ser Asp Gln Wing Thr Pro Wing Thr Ser Phe 295 300 305 gtg cag aag gaa ccc aac tac aac cag gca tcc ac gtc tac tcc 1075 Val Gln Lys Glu His Pro Asn Tyr Asn Gln Wing Ser Thr Val Tyr Ser 310 315 320 325 etc gac g cc gac aaa gcc aag gcg ctg gt gt gac gcc ac cct acc 1123 Leu Asp Wing Asp Lys Wing Lys Wing Leu Phe Wing Glu Thr Gly Leu Thr 330 335 340 age etc aac etc ctg tgc acc gac falls gac tgg gtc aag aac aac tgc acc 1171 Ser Leu Asn Leu Leu Cys Thr Asp His Asp Trp Val Lys Asn Cys Thr 345 350 355 cca ctg ate cag gaa tcc etc. 1192 Pro Leu He Gln Glu Ser Leu 360 <; 210 > 640 < 211 > 364 < 212 > PRT < 213 > Ccirynebact: er? Um gl .utamicum < 400 > 640 Met Cys Thr Asn Asn Thr Gly Thr Ser Gly Ser Thr Ser Thr Wing Wing 1 5 10 15 Gly Thr Gly Thr Wing Asn Glu Glu Gly Thr He Thr Wing Wing Being 20 25 30 Tyr Glu Leu Gly Thr Asn Gly Tyr Asp Pro Met Thr Thr Thr Ser Wing 35 40 45 Leu Thr Val Wing Wing Asn Trp His Thr Leu Glu Gly Leu Thr Glu He 50 55 60 Asp Pro Wing Thr Gly Glu Val Tyr Wing Wing Leu Wing Being Wing Leu Pro • 65 70 75 80 Wing Wing Asp Wing Thr Ser Leu Asp He Lys Leu Arg Asp Gly Wing Thr 85 90 95 Phe His Asn Gly Asp Wing Val Thr Wing Asp Asp Val Val Phe Ser Phe 100 105 110 Glu Arg Val Leu Asp Pro Wing Asn Asn Ser Leu Tyr Wing Ser Phe He 115 120 125 Pro Phe He Lys Ser Val Thr Lys Lys Asp Asp Thr Thr Val Thr He 130 135 140 Asp Leu Asp Tyr Wing Thr Gly He He Ser Glu Arg Leu Wing Val Val 145 150 155 160 10 Lys He Val Pro Lys Ser Val Val Glu Wing Asp Wing Ser Gly Phe Asp 165 170 175 Wing Asn Pro He Gly Ser Gly Pro Tyr Lys Met Thr Asp Asn Gly Wing 180 185 190 • Ser Lys Val Val Lys Phe Glu Arg Asn Asp Asp Tyr Asn Gly Pro Arg 195 200 2 05 Pro Wing Arg Wing Wing Lys Met Glu Trp Gln He He Pro Asp Wing Ser 210 215 220 Thr Arg Thr Asn Ser Leu Gln Ser Gly Ser Thr Met Wing He Asp Ser 225 230 235 240 Val Pro Tyr Leu Ser He Pro Gln Leu Glu Wing Thr Ser Thr Val Glu 245 250 255 15 Ser Val Gln Gly Phe Gly Leu Leu Phe Wing Met Phe Ser Cys Ser Glu 260 265 270 Gly Asn Pro Phe Asn Asp Val Arg Asn Arg Gln Wing Phe Leu Tyr Wing 275 280 285 Leu Asp Met Asp Lys He Val Lys Thr Gly Met Ser Asp Gln Wing Thr 290 295 300 Pro Wing Thr Ser Phe Val Gln Lys Glu His Pro Asn Tyr Asn Gln Wing 305 310 315 320 Ser Thr Val Tyr Ser Leu Asp Wing Asp Lys Wing Lys Wing Leu Phe Wing • 325 330 335 Glu Thr Gly Leu Thr Ser Leu Asn Leu Leu Cys Thr Asp His Asp Trp 340 345 350 20 Val Lys Asn Cys Thr Pro Leu He Gln Glu Ser Leu 355 360 < 210 > 641 < 211 > 1062 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (1062) < 223 > FRXA01382 25 tt? mt ?? ta IMÍÍÉ ^ ^ AM < 400 > 641 tcc action acc gca gct ggc acc gga act gca aat gaa gaa ggc acc 48 Be Thr Ser Thr Ala Ala Gly Thr Gly Thr Ala Asn Glu Glu Gly Thr 1 5 10 15 ate acc gca gcc ate tcc tac gaa ctg gga acc aac ggc tac gac cca 96 He Thr Wing Wing He Ser Tyr Glu Leu Gly Thr Asn Gly Tyr Asp Pro 20 25 30 atg acc action acc tcg gct etc act gtg gca gcc aac tgg falls acc ctt 144 Met Thr Thr Thr Ser Wing Leu Thr Val Wing Wing Asn Trp His Thr Leu 35 40 45 gaa ggc etc acc gaa ate gac ccc gcc acc ggc gag gtc tac gca gca 192 Glu Gly Leu Thr Glu He Asp Pro Wing Thr Gly Glu Val Tyr Ala Wing 50 55 60 etc gcc age gca ctg cct tca gcc gat gcg acc tcc cta gac ate aag 240 Leu Ala Be Ala Leu Pro Be Ala Asp Ala Thr Ser Leu Asp He Lys 65 70 75 80 ctt cgc gac ggc gcc acc ttc falls aac ggc gac gca gtc acc gca gac 288 Leu Arg Asp Gly Wing Thr Phe His Asn Gly Asp Wing Val Thr Wing Asp 85 90 95 gac gta gtc ttc tet ttt gag cga gtc etc gat cca gcc aac aac tcc 336 10 Asp Val Val Phe Ser Phe Glu Arg Val Leu Asp Pro Wing Asn Asn Ser 100 105 110 ctt tac gca tcc tcc ate cca ttc ate aag tca gtc acc aag aag gat 384 Leu Tyr Ala Ser Phe He Pro Phe He Lys Ser Val Thr Lys Lys Asp • 115 120 125 gac acc acc gtc acc ate gac etc gac tac gca acc ggc ate ate age 432 Asp Thr Thr Val Thr He Asp Leu Asp Tyr Wing Thr Gly He He Ser 130 135 140 gaa cgc etc gca gta gta aag ate gtg cca aag tcc gtc gtg gaa gca 480 Glu Arg Leu Wing Val Val Lys He Val Pro Lys Ser Val Val Glu Wing 145 150 155 160 gac gca tcc gga ttc gac gcc aac cca ate ggc tcc ggc cca tac aag 528 15 Asp Wing Ser Gly Phe Asp Wing Asn Pro He Gly Ser Gly Pro Tyr Lys 165 170 175 atg acc gac aac ggt gca tcc aag gtg gtc aag ttc gag cgc aac gac 576 Met Thr Asp Asn Gly Ala Ser Lys Val Val Lys Phe Glu Arg Asn Asp 180 185 190 gac tac aac ggc cca cgc cca gca cgt gcc gcc aag atg gaa tgg cag 624 Asp Tyr Asn Gly Pro Arg Pro Wing Arg Wing Wing Lys Met Glu Trp Gln 195 200 205 ate ate ccc gac gcc tcc acc cgc acc aac tcc ctt cag tcc ggc age 672 • He He Pro Asp Wing Being Thr Arg Thr Asn Being Leu Gln Being Gly Ser 210 215 220 acc atg gcc ate gac tcc gtt cca tac ctg tcg ate cca cag ctt gaa 720 20 Thr Met Wing He Asp Ser Val Pro Tyr Leu Ser He Pro Gln Leu Glu 225 230 235 240 gcc acc age acc gta gaa tcc gtc caa gga ttc ggc etc ctg ttc gcc 768 Wing Thr Ser Thr Val Glu Ser Val Gln Gly Phe Gly Leu Leu Phe Wing 245 250 255 atg ttc age tgc tcc gaa ggc aac ccc ttc aac gac gtc cgc aac cgc 816 Met Phe Ser Cys Ser Glu Gly Asn Pro Phe Asn Asp Val Arg Asn Arg 260 265 270 cag gca ttc etc tac gca ctg gac atg gac aag ate gtt aag acc ggc 864 Gln Ala Phe Leu Tyr Ala Leu Asp Met Asp Lys He Val Lys Thr Gly 275 280 285 atg tcc gac cag gca acc cca gcc acc tcc ttc gtg cag aag gaa cae 912 25 Met Ser Asp Gln Ala Thr Pro Ala Thr Ser Phe Val Gln Lys Glu His 290 295 300 ccc aac tac aac cag gca tcc acg gtc tac tcc etc gac gcc gac aaa 960 Pro Asn Tyr Asn Gln Wing Ser Thr Val Tyr Ser Leu Asp Wing Asp Lys 305 310 315 320 gcc aag gcg ctg ttc gct gaa acc ggc ctt acc age etc aac etc ctg 1008 Ala Lys Ala Leu Phe Ala Glu Thr Gly Leu Thr Ser Leu Asn Leu Leu 325 330 335 tgc acc gac falls gac tgg gtc aag aac tgc acc cca ctg ate cag gaa 1056 Cys Thr Asp His Asp Trp Val Lys Asn Cys Thr Pro Leu He Gln Glu • 340 345 350 tcc etc 1062 Ser Leu < 210 > 642 < 211 > 354 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 642 10 Be Thr Ser Thr Wing Wing Gly Thr Gly Thr Wing Asn Glu Glu Gly Thr 1 5 10 15 He Thr Wing Wing He Ser Tyr Glu Leu Gly Thr Asn Gly Tyr Asp Pro 20 25 30 • Met Thr Thr Thr Ser Ala Leu Thr Val Ala Ala Asn Trp His Thr Leu 35 40 45 Glu Gly Leu Thr Glu He Asp Pro Wing Thr Gly Glu Val Tyr Wing Wing 50 55 60 Leu Wing Wing Wing Leu Pro Wing Asp Wing Thr Ser Leu Asp He Lys 65 70 75 80 Leu Arg Asp Gly Wing Thr Phe His Asn Gly Asp Wing Val Thr Wing Asp 85 90 95 15 Asp Val Val Phe Ser Phe Glu Arg Val Leu Asp Pro Wing Asn Asn Ser 100 105 110 Leu Tyr Wing Being Phe He Pro Phe He Lys Ser Val Thr Lys Lys Asp 115 120 125 Asp Thr Thr Val Thr He Asp Leu Asp Tyr Wing Thr Gly He He Ser 130 135 140 Glu Arg Leu Wing Val Val Lys He Val Pro Lys Ser Val Val Glu Wing 145 150 155 160 Asp Wing Ser Gly Phe Asp Wing Asn Pro He Gly Ser Gly Pro Tyr Lys 165 170 175 Met Thr Asp Asn Gly Wing Ser Lys Val Val Lys Phe Glu Arg Asn Asp 180 185 190 20 Asp Tyr Asn Gly Pro Arg Pro Wing Arg Wing Wing Lys Met Glu Trp Gln 19 5 200 205 He He Pro Asp Wing Ser Thr Arg Thr Asn Ser Leu Gln Ser Gly Ser 210 215 220 Thr Met Wing He Asp Ser Val Pro Tyr Leu Ser He Pro Gln Leu Glu 225 230 235 240 Wing Thr Ser Thr Val Glu Ser Val Gln Gly Phe Gly Leu Leu Phe Wing 245 250 255 Met Phe Ser Cys Ser Glu Gly Asn Pro Phe Asn Asp Val Arg Asn Arg 260 265 270 Gln Wing Phe Leu Tyr Wing Leu Asp Met Asp Lys He Val Lys Thr Gly 275 280 285 25 Met Ser Asp Gln Ala Thr Pro Ala Thr Ser Phe Val Gln Lys Glu His H! ^ F ^^ JLj 290 295 300 Pro Asn Tyr Asn Gln Wing Ser Thr Val Tyr Ser Leu Asp Wing Asp Lys 305 310 315 320 Wing Lys Wing Leu Phe Wing Glu Thr Gly Leu Thr Ser Leu Asn Leu Leu 325 330 335 Cys Thr Asp His Asp Trp Val Lys Asn Cys Thr Pro Leu He Gln Glu 340 345 350 Ser Leu • < 210 > 643 < 211 > 335 < 212 > DNA < 213 > Coryntsbacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (312¡ 1 < 223 > RXA02659 < 400 > 643 10 ttc ggc aac gac cca gac etc etc atg cgc tgg tgg tac gcc ggc gac 48 Phe Gly Asn Asp Pro Asp Leu Leu Met Arg Trp Trp Tyr Wing Gly Asp 1 5 10 15 gtc tgg acc gac tcc cgc atg falls tgg aag ggc age gaa tcc tac gac 96 ^ I Val Trp Thr Asp Ser Arg Met His Trp Lys Gly Ser Glu Ser Tyr Asp 20 25 30 cag gta caa aac etc ctg gaa gaa ggc ate cgc gct acc gac aag gca 144 Gln Val Gln Asn Leu Leu Glu Glu Gly He Arg Wing Thr Asp Lys Wing 35 40 45 gaa cag caa gac ate tgg aac cgc acc ttc gat gtc ate tcc gac aat 192 Glu Gln Gln Asp He Trp Asn Arg Thr Phe Asp Val He As Asn Asn 50 55 60 15 gtt ccc etc tac ccg ctg ttc falls cgc aag gtc cca acc gca tgg aac 240 Val Pro Leu Tyr Pro Leu Phe His Arg Lys Val Pro Thr Wing Trp Asn 65 70 75 80 tcc aac gcc etc gtc gac ttc aag cca ate tca etc acc ggc ttg aac 288 Be Asn Ala Leu Val Asp Phe Lys Pro Be Ser Leu Thr Gly Leu Asn 85 90 95 ttc tca ggt gtt gca act act gaa taacaacccc agtggctttc aaa 335 Phe Ser Gly Val Ala Thr Thr Glu 100 • < 210 > 644 < 211 > 104 20 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 644 Phe Gly Asn Asp Pro Asp Leu Leu Met Arg Trp Trp Tyr Wing Gly Asp 1 5 10 15 Val Trp Thr Asp Ser Arg Met His Trp Lys Gly Ser Glu Ser Tyr Asp 20 25 30 Gln Val Gln Asn Leu Leu Glu Glu Gly He Arg Wing Thr Asp Lys Wing 35 40 45 Glu Gln Gln Asp He Trp Asn Arg Thr Phe Asp Val He As Asn Asn 50 55 60 25 Val Pro Leu Tyr Pro Leu Phe His Arg Lys Val Pro Thr Wing Trp Asn AußHUii 65 70 75 80 Be Asn Ala Leu Val Asp Phe Lys Pro Be Ser Leu Thr Gly Leu Asn 85 90 95 Phe Ser Gly Val Ala Thr Thr Glu 100 < 210 > 645 < 211 > 933 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (910) < 223 > RXN02933 < 400 > 645 tgatctgctg -tatcaggtgg t "tgaticcaaig agtcggtgct gttggggttg ictag < cactaa 60 ggttccaiggg, agcgtggctt aagtgacaac gatcaaaaac atg ccc ctt tca ggg 115 Met Pro Leu Ser Gly 1 5 aaa ate ggc ggc ttc ate gtt gcc gtt gtt ttt gtt ctt gct gcg ctg 163 Lys He Gly Gly Phe He Val Wing Val Val Phe Val Leu Ala Wing Leu 10 15 20 tet ttc att tgg act ccg ttt gat cca gtt caa gct tcc cca cag gag 211 Be Phe He Trp Thr Pro Phe Asp Pro Val Gln Ala Phe Pro Gln Glu 25 30 35 cgc ctt gag gga agt tet ttg agg cae ctg ttg gga acg gat cgt tat 259 Arg Leu Glu Gly Ser Ser Leu Arg His Leu Leu Gly Thr Asp Arg Tyr 40 45 50 ggt cgc gat gtt tta tc cg cag ate tg ggt gcc tcc cgc gtc acg ttg 307 Gly Arg Asp Val Leu Ser Gln He Met Val Gly Ser Arg Val Thr Leu 55 60 65 ttg gtg ggc ate att gcg gtg gcg ate gca gca tta ate ggc acg cca 355 Leu Val Gly He He Ala Ala Ala Ala He Ala Ala Leu He Gly Thr Pro 70 75 80 85 ctg ggt att gct gcg gga atg cgc cgt ggc atg gtg gaa acc ttt gtc 403 Leu Gly He Wing Wing Gly Met Arg Arg Gly Met Val Glu Thr Phe Val 90 95 100 atg cgt ggt gcc gat tta atg ttg gcg ttc cca gca ctg ttg ttg gcg 451 Met Arg Gly Wing Asp Leu Met Leu Wing Phe Pro Wing Leu Leu Leu Wing 105 110 115 att att tcc ggc gcc gtt ttc ggc gcc tcc acg tgg tcc gcg atg gtc 499 He He Ser Gly Wing Val Phe Gly Wing Ser Thr Trp Ser Wing Met Val 120 125 130 gcg ate ggc ate gca ggc ate cct agt ttt gcc cgc gtg gct cgt gca 547 Wing He Gly Wing Wing Gly He Pro Wing Phe Wing Arg Wing Wing Arg Wing 135 140 145 ggc here ttg cag gtg acc agt cag gat ttc ate gca gct gct cgg cta 595 Gly Thr Leu Gln Val Thr Ser Gln Asp Phe He Ala Wing Wing Arg Leu 150 155 160 165 tca aaa gta agt tcc gcc cgg ate gcg ctt cgc cat att ttg ccc aac 643 Ser Lys Val Ser Ser Wing Arg He Wing Leu Arg His He Leu Pro Asn 170 175 180 ate acc atg ttg ate gtt cag gca tca gta gtt ttt gcc ctg gcg 691 He Thr Ser Met Leu He Val Gln Ala Ser Val Ala Phe Ala Leu Ala 185 190 195 ate ctg gcg gaa gcc gca ttg agt ttc etc ggt ttg ggc acc act ccc 739 He Leu Ala Glu Ala Ala Leu Ser Phe Leu Gly Leu Gly Thr Thr Pro 200 205 210 ccg gat ccc age tgg ggt cgc atg ttg caa acc gct caa gca tcc ate 787 Pro Asp Pro Ser Trp Gly Arg Met Leu Gln Thr Ala Gln Ala Ser He 215 220 225 ggc gtc acc ccc atg ttg gcg gtg tgg ccc ggt gct gcg ate gct ttg 835 Gly Val Thr Pro Met Leu Ala Val Trp Pro Gly Ala Wing Ala Wing Leu 230 235 240 245 acg gtc ctt gtt ttt aat ctt ttc ggt gat ggt tta cgc gat gcc ate 883 Thr Val Leu Gly Phe Asn Leu Phe Gly Asp Gly Leu Arg Asp Ala He 250 255 260 gat cca aag cgg gag gtc ggc cgt gct taaagtttct gattt: aacgg 930 Asp Pro Lys Arg Glu Val Gly Arg Ala 265 270 ttg 933 < 210 > 646 < 211 > 270 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 646 Met Pro Leu Ser Gly Lys He Gly Gly Phe He Val Wing Val Val Phe 1 5 10 15 Val Leu Ala Ala Leu Ser Phe He Trp Thr Pro Phe Asp Pro Val Gln 20 25 30 Wing Phe Pro Gln Glu Arg Leu Glu Gly Ser Ser Leu Arg His Leu Leu 35 40 45 Gly Thr Asp Arg Tyr Gly Arg Asp Val Leu Ser Gln He Met Val Val Gly 50 55 60 Ser Arg Val Thr Leu Leu Val Gly He He Ala Ala Ala Ala Ala Ala 65 70 75 80 Leu He Gly Thr Pro Leu Gly He Wing Wing Gly Met Arg Arg Gly Met 85 90 95 Val Glu Thr Phe Val Met Arg Gly Wing Asp Leu Met Leu Wing Phe Pro 100 105 110 Wing Leu Leu Leu Wing He He Ser Gly Wing Val Phe Gly Wing Being Thr 115 120 125 Trp Being Wing Met Val Wing He Gly He Wing Gly He Pro Being Phe Wing 130 135 140 Arg Val Ala Arg Ala Gly Thr Leu Gln Val Thr Ser Gln Asp Phe He 145 150 155 160 Ala Ala Ala Arg Leu Ser Lys Val Ser Be Ala Arg He Ala Ala Leu Arg 165 170 175 His He Leu Pro Asn He Thr Ser Met Leu He Val Gln Ala Ser Val 180 185 190 Wing Phe Wing Leu Wing He Leu Wing Glu Wing Wing Leu Be Phe Leu Gly 195 200 205 Leu Gly Thr Pro Pro Asp Pro Be Trp Gly Arg Met Leu Gln Thr 210 215 220 Ala Gln Ala Ser He Gly Val Thr Pro Met Leu Ala Val Trp Pro Gly 225 230 235 240 Ala Ala He Ala Leu Thr Val Leu Gly Phe Asn Leu Phe Gly Asp Gly 245 250 255 Leu Arg Asp Ala He Asp Pro Lys Arg Glu Val Gly Arg Ala 260 265 270 < 210 > 647 < 211 > 715 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (715) < 223 > RXN02991 < 400 > 647 ttgtcgtgtt, cgcgatcttc g, ccgttggct tcatgattct gaccctgcct; atgggccttg 60 gcttgggcaa, actetetg; ag c? Gtttggcgg tg; aagaagta atg gct aat here gtt 115 Met Wing Asn Thr Val 1 5 cgc gca here gtc etc tac gat gct cct gga cca aag ggc cgt cga ttc 163 Arg Ala Thr Val Leu Tyr Asp Wing Pro Gly Pro Lys Gly Arg Arg Phe 10 15 20 aac etc ata ate acc att etc acg gtg gtt ctg gga ttg gcg etc etc 211 Asn Leu He He Thr He Leu Thr Val Val Leu Gly Leu Ala Leu Leu 25 30 35 ttc tgg att ggc tcc atg ctt tca ggc aac ggc caa etc gat gcc aac 259 Phe Trp He Gly Ser Met Leu Ser Gly Asn Gly Gln Leu Asp Wing Asn 40 45 50 aaa tgg act ccg ttc ate aat tcc caa acc tgg acc tc ata att ctt 307 Lys Trp Thr Pro Phe He Asn Ser Gln Thr Trp Thr Thr Tyr He Leu 55 60 65 cct ggt ttg tgg ggc acg ctg aaa tet gcc gtg ttc tcg gtg ate ttg 355 Pro Gly Leu Trp Gly Thr Leu Lys Ser Wing Val Phe Ser Val He Leu 70 75 80 85 gct ctg gtc atg ggt acc gca ctg ggt ctt ggc cgt ate tet gaa ate 403 Ala Leu Val Met Gly Thr Ala Leu Gly Leu Gly Arg He Ser Glu He 90 95 100 agg att etc cgc tgg ttc tgc gcc gtc ate ate gag act ttc cga gcc 451 Arg He Leu Arg Trp Phe Cys Ala Val He He Glu Thr Phe Arg Ala 105 110 115 att ccg gtt ctg ate etc atg att ttc gcc tac cag atg ttc gcc cag 499 He Pro Val Leu He Leu Met He Phe Wing Tyr Gln Met Phe Wing Gln 120 125 130 tac aac ate gtg ccg age cag etc gcg ttc gcc gcc gtg gta ttc 547 Tyr Asn He Val Pro Ser Ser Gln Leu Ala Phe Ala Ala Val Val Phe 135 140 145 ggt ctg acc atg tac aac ggt tet gtg ate gca gag att ctg cgt tet 595 Gly Leu Thr Met Tyr Asn Gly Ser Val He Wing Glu He Leu Arg Ser 150 155 160 165 ggt ate gct tcc ctg cct aag ggg cag aag gaa gca gcg att gcg ttg 643 Gly He Wing Being Leu Pro Lys Gly Gln Lys Glu Wing Wing He Wing Leu 170 175 180 ggt atg tet tet agg caa acc acc tgg tca ate ttg ttg cct cag gcc 691 Gly Met Being Ser Arg Gln Thr Thr Trp Being He Leu Leu Pro Gln Wing 185 190 195 gtg gct gca atg etc cca gcg ttg 715 Val Ala Ala Met Leu Pro Ala Leu 200 205 < 210 > 648 < 211 > 205 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 648 Met Wing Asn Thr Val Arg Wing Thr Val Leu Tyr Asp Wing Pro Gly Pro 1 5 10 15 Lys Gly Arg Arg Phe Asn Leu He He Thr He Leu Thr Val Val Leu 20 25 30 Gly Leu Ala Leu Leu Phe Trp He Gly Ser Met Leu Ser Gly Asn Gly 35 40 45 Gln Leu Asp Wing Asn Lys Trp Thr Pro Phe He Asn Ser Gln Thr Trp 50 55 60 Thr Thr Tyr He Leu Pro Gly Leu Trp Gly Thr Leu Lys Ser Wing Val 65 70 75 80 Phe Ser Val He Leu Ala Leu Val Met Gly Thr Ala Leu Gly Leu Gly 85 90 95 Arg He Ser Glu He Arg He Leu Arg Trp Phe Cys Ala Val He He 100 105 110 Glu Thr Phe Arg Ala He Pro Val Leu He Leu Met He Phe Ala Tyr 115 120 125 Gln Met Phe Ala Gln Tyr Asn He Val Pro Ser Ser Gln Leu Ala Phe 130 135 140 Ala Ala Val Val Phe Gly Leu Thr Met Tyr Asn Gly Ser Val He Ala 145 150 155 160 Glu He Leu Arg Being Gly He Wing Being Leu Pro Lys Gly Gln Lys Glu 165 170 175 Wing Wing Wing Leu Gly Met Being Serg Arg Gln Thr Thr Trp Ser He 180 185 190 Leu Leu Pro Gln Wing Val Wing Wing Met Leu Pro Wing Leu 195 200 205 < 210 > 649 < 211 > 245 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 >; (1) .. (222) < 223 > RXN02992 < 400 > 649 ate gtc cct ttg ggc aac here ctg ate gca ctg act aag aac acc acc 48 He Val Pro Leu Gly Asn Thr Leu He Ala Leu Thr Lys Asn Thr Thr 1 5 10 15 ate gcc tet gtc att gga gtt ggc gaa gcc tcc ctg ctg atg aaa gcc 96 He Wing Being Val He Gly Val Gly Glu Wing Being Leu Leu Met Lys Wing 20 25 30 acc ate gaa aat falls gcc aac atg cta ttt gtc gtg tcc gcg ate ttc 144 Thr He Glu Asn His Wing Asn Met Leu Phe Val Val Phe Wing He Phe 35 40 45 gcc gtt ggc ttc atg att ctg acc ctg cctg cct atg ggc ctt ggc ttg ggc 192 Wing Val Gly Phe Met He Leu Thr Leu Pro Met Gly Leu Gly Leu Gly 50 55 60 aaa etc tet gag cgt ttg gcg gtg aag aag taatggctaa tacagttege 242 Lys Leu Ser Glu Arg Leu Ala Val Lys Lys 65 70 gca 245 < 210 > 650 < 211 > 74 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 650 He Val Pro Leu Gly Asn Thr Leu He Wing Leu Thr Lys Asn Thr Thr 1 5 10 15 He Wing Being Val He Gly Val Gly Glu Wing Being Leu Leu Met Lys Wing 20 25 30 Thr He Glu Asn His Wing Asn Met Leu Phe Val Val Phe Wing He Phe 35 40 45 Wing Val Gly Phe Met He Leu Thr Leu Pro Met Gly Leu Gly Leu Gly 50 55 60 Lys Leu Ser Glu Arg Leu Wing Val Lys Lys 65 70 < 210 > 651 < 211 > 792 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (769) < 223 > RXN02996 < 400 > 651 tcctgccaca < gaatctgcct gctgctccat taactaaaaa ttgcaggcta gaatagaggg 60 tcgattagga < gtcgatgaaa aagtcggcgc caacgaggag atg aac aac aac aac gtg 115 Met Asn Asn Asn Val 1 5 agt gat caa aag cta agt ggt aaa gag ctt gcg gca cta gag aaa caa 163 Ser Asp Gln Lys Leu Ser Gly Lys Glu Leu Ala Wing Leu Glu Lys Gln 10 15 20 gcc gca aaa act etc gaa ctt ggt gat aag aag agg tat tat gcg 211 Ala Wing Lys Thr Leu Glu Leu Gly Asp Lys Lys Trp Tyr Leu He Wing 25 30 35 gga gtc gtg ctt ttc gcc ate gca etc gtc etc cca cat ate cgt gga 259 Gly Val Val Leu Phe Ala He Ala Leu Val Leu Pro His He Arg Gly 40 45 50 gtg atg ggc tgg cag gtt ctg acg ctg tcg aat gtc gcg gag gat gcc 307 Val Met Gly Trp Gln Val Leu Thr Leu Ser Asn Val Ala Glu Asp Wing 55 60 65 ggc att acc ctt ggt gag tac ggt ttc tac tgg ttg ggc acc ate ggt 355 Gly He Thr Leu Gly Glu Tyr Gly Phe Tyr Trp Leu Gly Thr He Gly 70 75 80 85 gta ttc ctg ctt tet ttg ggc act gtc gtg ttt aag cgc acg tgg atg 403 Val Phe Leu Leu Ser Leu Gly Thr Val Val Phe Lys Arg Thr Trp Met 90 95 100 gcg tgg att tca tgg att ttc tcc tgc gtc act ctt gtg t tc gct gtg 451 Wing Trp He Ser Trp He Phe Ser Cys Val Thr Leu Val Phe Wing Val 105 110 115 ttt gcc ate tgg atg cgc caa here acc acc age action gtg aat ttc 499 Phe Wing He Trp Met Arg Gln Thr Thr Thr Ser Thr Gln Val Asn Phe 120 125 130 gtc aac att ggc atg att ctt gct gtg att gca gcg ate ctt gct gtg 547 Val Asn He Gly Met Met Leu Wing Val He Wing Wing He Leu Wing Val 135 140 145 tgg ggt cta tet tcg gtg att ttg gcc cgc agt gat cgc caa atg gag 595 Trp Gly Leu Ser Ser Val He Leu Wing Arg Ser Asp Arg Gln Met Glu 150 155 160 165 ate gct gaa atg cgc gcc gag aac cca gac ctt gat ggt gtt gca gct 643 • Wing Wing Glu Met Arg Wing Glu Asn Pro Asp Leu Asp Gly Val Wing Wing 170 175 180 cgc cgc gt ctt ctt gag cag cag caa age aac cca gaa gat aat 691 Thr Gln Arg Wing Leu Leu Glu Gln Gln Gln Ser Asn Pro Glu Asp Asn 185 190 195 cct ttg ctt gtc gac gat cgt cgc gcc cgc ate gcc cgc cgc cgc gag 739 Pro Leu Leu Val Asp Asp Arg Arg Ala Arg He Wing Arg Arg Arg Glu 200 205 210 cgt gaa cag gat gca cag ggg gag cag gct taatgttctag ttcaagcggt 789 Arg Glu Gln Asp Wing Gln Gly Glu Gln Wing 215 220 10 tga 792 < 210 > 652 < 211 > 223 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 652 Met Asn Asn Asn Val Ser Asp Gln Lys Leu Ser Gly Lys Glu Leu Wing 1 5 10 15 Wing Leu Glu Lys Gln Wing Wing Lys Thr Leu Glu Leu Gly Asp Lys Lys 20 25 30 15 Trp Tyr Leu He Wing Gly Val Val Leu Phe Ala He Ala Leu Val Leu 35 40 45 Pro His He Arg Gly Val Met Gly Trp Gln Val Leu Thr Leu Ser Asn 50 55 60 Val Wing Glu Asp Wing Gly He Thr Leu Gly Glu Tyr Gly Phe Tyr Trp 65 70 75 80 Leu Gly Thr He Gly Val Phe Leu Leu Ser Leu Gly Thr Val Val Phe 85 90 95 Lys Arg Thr Trp Met Wing Trp He Ser Trp He Phe Ser Cys Val Thr • 100 105 110 Leu Val Phe Wing Val Phe Wing He Trp Met Arg Gln Thr Thr Thr Ser 115 120 125 20 Thr Gln Val Asn Phe Val Asn He Gly Met Met Leu Wing Val He Wing 130 135 140 Wing He Leu Wing Val Trp Gly Leu Ser Ser Val Le Leu Ala Arg Ser 145 150 155 160 Asp Arg Gln Met Glu He Wing Glu Met Arg Wing Glu Asn Pro Asp Leu 165 170 175 Asp Gly Val Wing Wing Thr Gln Arg Wing Leu Leu Glu Gln Gln Gln Ser 180 185 190 Asn Pro Glu Asp Asn Pro Leu Leu Val Asp Asp Arg Arg Ala Arg He 195 200 205 Wing Arg Arg Arg Glu Arg Glu Gln Asp Wing Gln Gly Glu Gln Wing 210 215 220 25 > * .ft «, ü .Í t ¿aüÜÉiattafcrfM < 210 > 653 < 211 > 1017 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (994) < 223 > RXN03126 • < 400 > 653 tcttggacaa cattacccca cacacgggac actcaaacgt gcatgaattc acctgtcgtc 60 gatacccaaa aatcactcca ccaccactag ggtgtcttat gtg cag gaa caa tcg 115 Val Gln Glu Gln Ser 1 5 aag cag aaa gac etc cag gct gat ate gcc aga ate act gcc gtg aaa 163 Lys Gln Lys Asp Leu Gln Wing Asp He Wing Arg He Thr Wing Val Lys 10 15 20 tcg gac here gtt ccg aat tcc cag tca atg acc ttt ggc gct gcc tgg 211 Be Asp Thr Val Pro Asn Ser Gln Ser Met Thr Phe Gly Ala Wing Trp 10 25 30 35 aac gat ate gtc cgc gga ttc aag caa cat gag ttg tgg ctg caa etc. 259 Asn Asp He Val Arg Gly Phe Lys Gln His Glu Leu Trp Leu Gln Leu 40 45 50 • ggc tgg caa gac att aag caa cgc tac cgg cga tcc gtc ctt ggg ccc 307 Gly Trp Gln Asp He Lys Gln Arg Tyr Arg Arg Ser Val Leu Gly Pro 55 60 65 ctg tgg ate acc ate gcc ggc gtc atg gcg etc gcc etc ggc ttg 355 Leu Trp He Thr He Wing Thr Gly Val Met Wing Leu Wing Leu Gly Leu 70 75 80 85 ctg tac tcc gtg ctg ttc aaa ate cc cct ate gcg gaa ttt ctg ccc cae 403 Leu Tyr Ser Val Leu Phe Lys He Pro He Wing Glu Phe Leu Pro His 15 90 95 100 gtc acc gtc ggc ctg ate att tgg aac ttc ate tcc gga tgc ate aaa 451 Val Thr Val Gly Leu He He Trp Asn Phe He Ser Gly Cys He Lys 105 110 115 gaa ggc tcc gac ate ttc ata gat aac gag gga etc ate aaa cag etc 499 Glu Gly Be Asp He Phe He Asp Asn Glu Gly Leu He Lys Gln Leu 120 125 130 ccc tcg gcg ctg tcc gtc falls gtg tac aga etc gtg tgg aaa caa gcc 547 Pro Be Ala Leu Ser Val His Val Tyr Arg Leu Val Trp Lys Gln Wing • 135 140 145 etc ttc etc gcc falls aac ctg gtc ate tgg gtc att etc atg atg ate 595 Leu Phe Leu Ala His Asn Leu Val He Trp Val He Leu Met Met He 20 150 155 160 165 ttc ccc cga ccc etc ggc tgg gac gtc etc ctg ate ate ccc gca atg 643 Phe Pro Arg Pro Leu Gly Trp Asp Val Leu Leu He He Pro Wing Met 170 175 180 ttc etc ctg gtg ate aac ggc gtg tgg gta gtc atg ttc ttc ggc ate 691 Phe Leu Leu Val He Asn Gly Val Trp Val Val Met Phe Phe Gly He 185 190 195 ate gcc acc cgc tac cgc gac gtc tcc ccg ttg cta gaa gcc gga acc 739 He Wing Thr Arg Tyr Arg Asp Val Ser Pro Leu Leu Glu Wing Gly Thr 200 205 210 caa etc etc ttc tac gtc acc ccc ate gtc tgg atg act tcc acc ctg 787 Gln Leu Leu Phe Tyr Val Thr Pro He Val Trp Met Thr Ser Thr Leu 25 215 220 225 IJL.? Í.Í ^ «í * L« .. caa tcc cag age gca gca gaa ate ggc aac cgc gca cgc etc gcc gaa etc 835 Gln Ser Gln Ser Wing Glu He Gly Asn Arg Wing Arg Leu Wing Glu Leu 230 235 240 245 aac ccg etc tac falls tac etc gaa att gtc cgc gcc ccc atg gtc ggc 883 Asn Pro Leu Tyr His Tyr Leu Glu He Val Arg Ala Pro Met Val Gly 250 255 260 gcc gac etc ccc gcc tac falls tgg tgg tgg ttc gcc tcc here tcc 931 Wing Asp Leu Pro Wing Tyr His Trp Trp He Val Leu Ala Phe Thr Phe 265 270 275 • gtc ggc ctt ggc ctt gct etc etc gcg atg aag caa tgg cga tcc cgc 979 Val Gly Leu Gly Leu Ala Leu Leu Wing Met Lys Gln Trp Arg Phe Arg 280 285 290 gtc age tac tgg gta taaggagcac cacatggtat cca 1017 Val Ser Tyr Trp Val 295 < 210 > 654 < 211 > 298 < 212 > PRT < 213 > Corynebacterium glutamicum 10 < 400 > 654 Val Gln Glu Gln Ser Lys Gln Lys Asp Leu Gln Wing Asp He Wing Arg 1 5 10 15 • He Thr Wing Val Lys Ser Asp Thr Val Pro Asn Ser Gln Ser Met Thr 20 25 30 Phe Gly Wing Wing Trp Asn Asp He Val Arg Gly Phe Lys Gln His Glu 35 40 45 Leu Trp Leu Gln Leu Gly Trp Gln Asp He Lys Gln Arg Tyr Arg Arg 50 55 60 Ser Val Leu Gly Pro Leu Trp He Thr He Wing Thr Gly Val Met Wing 65 70 75 80 15 Leu Ala Leu Gly Leu Leu Tyr Ser Val Leu Phe Lys He Pro Wing 85 90 95 Glu Phe Leu Pro His Val Thr Val Gly Leu He He Trp Asn Phe He 100 105 110 Ser Gly Cys He Lys Glu Gly Ser Asp He Phe He Asp Asn Glu Gly 115 120 125 Leu He Lys Gln Leu Pro Be Ala Leu Ser Val His Val Tyr Arg Leu 130 135 140 Val Trp Lys Gln Ala Leu Phe Leu Ala His Asn Leu Val He Trp Val • 145 150 155 160 He Leu Met Met He Phe Pro Arg Pro Leu Gly Trp Asp Val Leu Leu 165 170 175 20 He He Pro Wing Met Phe Leu Leu Val He Asn Gly Val Trp Val Val 180 185 190 Met Phe Phe Gly He He Wing Thr Arg Tyr Arg Asp Val Ser Pro Leu 195 200 205 Leu Glu Wing Gly Thr Gln Leu Leu Phe Tyr Val Thr Pro He Val Trp 210 215 220 Met Thr Ser Thr Leu Gln Ser Gln Ser Wing Glu He Gly Asn Arg Wing 225 230 235 240 Arg Leu Wing Glu Leu Asn Pro Leu Tyr His Tyr Leu Glu He Val Arg 245 250 255 Wing Pro Met Val Gly Wing Asp Leu Pro Wing Tyr His Trp Trp He Val 260 265 270 25 Leu Wing Phe Thr Phe Val Gly Leu Gly Leu Wing Leu Leu Wing Met Lys FRIENDLY? ? r ?? .j.? . .. i __ ». , __, __..______ .. _, _ __, "_." _, - - - -i - '- .-' "- - *. *.,.! - * .. i 275 280 285 Gln Trp Arg Phe Arg Val Ser Tyr Trp Val 290 295 <210> 655 <211> 927 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS < 222 > (101) .. (904) < 223 > RXN00443 < 400 > 655 taaacaaigga igcgt-ttaa1tt tccacccaat cccactigaaa gtttcccacc < ecacagttat 60 gctgatt, aag -tact < gaactt accgtaggaa aggcactcag gtg aac aaa agt ate 115 Val Asn Lys Ser He 1 5 cgt cga gct etc tac agt ttc ate act tcg at gcg ggt ate tca etc 163 10 Arg Arg Ala Leu Tyr Ser Phe He Thr He Ser Wing Gly He Ser Leu 10 15 20 gta gcg tgc tet tet tca gac acc gca age act acc acc gg cag aat gcc 211 Val Ala Cys Being Ser Asp Thr Ala Being Thr Thr Thr Gln Asn Ala • 25 30 35 tet gct acc gaa gca gct ggg gtt tcc gga acc gct age gtt ttc gct 259 Be Wing Thr Glu Wing Wing Gly Val Ser Gly Thr Wing Ser Val Phe Wing 40 45 50 gcg gcg tet ttg acc aac gtt gct gag gat etc gcg gct gcg ttc aac 307 Ala Ala Ser Leu Thr Asn Val Ala Glu Asp Leu Ala Ala Ala Phe Asn 55 60 65 gaa gac aat cct gat gca aag ttg gag ttt aac ttc gct ggt tet tcc 355 15 Glu Asp Asn Pro Asp Wing Lys Leu Glu Phe Asn Phe Wing Gly Ser Ser 70 75 80 85 gcg ctg gtt cgc cag ate age gaa ggc gca cca tet gat ctg ttc att 403 Ala Leu Val Arg Gln He Ser Glu Gly Ala Pro Ser Asp Leu Phe He 90 95 100 tet gcg gac ate gcc aac atc gac gat gcg ctg gca ctt cca gaa ttt 451 Be Wing Asp He Wing Asn Met Asp Asp Wing Leu Wing Leu Pro Glu Phe 105 110 115 gcc ggc gc acc tcg aag gtc ate gct acc aac aag ctg gtg ctg gtc 499 • Wing Gly Wing Thr Ser Lys Val He Wing Thr Asn Lys Leu Val Leu Val 120 125 130 acc gca gac ggc aac ccc ggc gaa att tca gag ctt gcc gac gtc aag 547 20 Thr Wing Asp Gly Asn Pro Gly Glu He Ser Glu Leu Wing Asp Val Lys 135 140 145 gac tcc etc gtt gct ate tgc gcc cct gaa gtt cca tgt gga acc ate 595 Asp Ser Leu Val Wing He Cys Wing Pro Glu Val Pro Cys Gly Thr He 150 155 160 165 acc falls gag gct ttg gac tac gca gac ate gag ttg aac acc age tet 643 Thr His Glu Wing Leu Asp Tyr Wing Asp He Glu Leu Asn Thr Ser Ser 170 175 180 gag gaa gcc aat gtt gct gat gtc gcc acg aag att tcc acc ggt gca 691 Glu Glu Wing Asn Val Wing Asp Val Wing Thr Lys He Ser Thr Gly Wing 185 190 195 gtt gat gcg ggc ttt gtt tac caa acc gac gct cag tet ttg gct aaa 739 25 Val Asp Ala Gly Phe Val Tyr Gln Thr Asp Ala Gln Ser Leu Ala Lys - • -A - * fe-. - "*» - "* - 200 205 210 act cag gac aac act gtc att gaa etc gaa ggt ate gac gcc aac gaa 787 Thr Gln Asp Asn Thr Val He Glu Leu Glu Gly He Asp Ala Asn Glu 215 220 225 tac cca atg gca ttg acc action acc ggt gaa gac aac gag gta gcg aag 835 Tyr Pro Met Ala Leu Thr Thr Thr Gly Glu Asp Asn Glu Val Wing Lys 230 235 240 245 gct ttc gca gag ttc etc age age gat cgt gcc aag gag ate ctt gcc 883 Wing Phe Wing Glu Phe Leu Being Ser Asp Arg Wing Lys Glu He Leu Wing 250 255 260 age tat ggt ttt ggc here aac taaaaaggct cgtcgaagcg aga 927 Ser Tyr Gly Phe Gly Thr Asn 265 < 210 > 656 < 211 > 268 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 656 Val Asn Lys Ser He Arg Arg Ala Leu Tyr Ser Phe He Thr He Ser 1 5 10 15 Wing Gly He Ser Leu Val Wing Cys Being Ser Asp Thr Wing Being Thr 20 25 30 Thr Thr Gln Asn Wing Being Wing Thr Glu Wing Wing Gly Val Ser Gly Thr 35 40 45 Wing Ser Val Phe Ala Wing Wing Ser Leu Thr Asn Val Wing Glu Asp Leu 50 55 60 Wing Wing Wing Phe Asn Glu Asp Asn Pro Asp Wing Lys Leu Glu Phe Asn 65 70 75 80 Phe Wing Gly Being Wing Leu Val Arg Gln He Ser Glu Gly Wing Pro 85 90 95 Being Asp Leu Phe He Being Wing Asp He Wing Asn Met Asp Asp Wing Leu 100 105 110 Wing Leu Pro Glu Phe Wing Gly Wing Thr Ser Lys Val He Wing Thr Asn 115 120 125 Lys Leu Val Leu Val Thr Wing Asp Gly Asn Pro Gly Glu He Ser Glu 130 135 140 Leu Wing Asp Val Lys Asp Ser Leu Val Wing He Cys Wing Pro Glu Val 145 150 155 160 Pro Cys Gly Thr He Thr His Glu Wing Leu Asp Tyr Wing Asp He Glu 165 170 175 Leu Asn Thr Ser Ser Glu Glu Wing Asn Val Wing Asp Val Wing Thr Lys 180 185 190 He Ser Thr Gly Wing Val Asp Wing Gly Phe Val Tyr Gln Thr Asp Wing 195 200 205 Gln Ser Leu Wing Lys Thr Gln Asp Asn Thr Val He Glu Leu Glu Gly 210 215 220 He Asp Wing Asn Glu Tyr Pro Met Wing Leu Thr Thr Thr Gly Glu Asp 225 230 235 240 Asn Glu Val Wing Lys Wing Phe Wing Glu Phe Leu Being Ser Asp Arg Wing 245 250 255 Lys Glu He Leu Wing Being Tyr Gly Phe Gly Thr Asn 260 265 < 210 > 657 < 211 > 960 t, ».. * ... ± ..- * .., # 4L. *. r .. +. TO,.. . MMMMti < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (937) < 223 > RXN00444 < 400 > 657 tacecaatgg cattgaccac caccggtgaa gacaaegagg tagcgaaggc tttcgcagag 60 ttcctcagca gcgatcgtgc caaggagatc cttgccagct atg gtt ttg gca caa 115 Met Val Leu Ala Gln 1 5 act aaa aag gct cgt cga age gag aat cat ate etc cca ggg tgg ttg 163 Thr Lys Lys Ala Arg Arg Ser Glu Asn His He Leu Pro Gly Trp Leu 10 15 20 etc ate cca gcc acc ctg gcc atg ctg ctg ate att gga cct att ttt 211 Leu He Pro Wing Thr Leu Wing Met Leu Leu He He Gly Pro He Phe 25 30 35 gct ttg ctg ttg cag ate ccc tgg gat cgg tet tgg gag ttg ctt acc 259 10 Wing Leu Leu Leu Gln He Pro Trp Asp Arg Ser Trp Glu Leu Leu Thr 40 45 50 gcg ccg gaa tet tta gga acc gca cgg tta tet tet ate gga act gct ctg 307 Wing Pro Glu Be Leu Gly Thr Wing Arg Leu Be He Gly Thr Wing Leu • 55 60 65 ttt tet tcc gcg cta tgc gca att gtg gtc tcc ccg cc gcg ttg gcg 355 Phe Ser Thr Ala Leu Cys Ala He Val Gly Phe Pro Leu Ala Leu Ala 70 75 80 85 ctg cat tta tat gag cgt tcg falls ccc agg gtg here tca gtt ttg acg 403 Leu His Leu Tyr Glu Arg Ser His Pro Ar g Val Thr Ser Val Leu Thr 90 95 100 gtg ctg gtt tat gcg cct ttg gtg ttg tcg ccg gtg gtg tet ggt ttg 451 15 Val Leu Val Tyr Ala Pro Leu Val Leu Ser Pro Val Val Ser Gly Leu 105 110 115 gcg ctg act ttt ctg tgg ggc agg cgt ggt ttt tta ggt tet tgg ctt 499 Wing Leu Thr Phe Leu Trp Gly Arg Arg Gly Phe Leu Gly Ser Trp Leu 120 125 130 gat cag gtt gt gt ttg gt gt gtg gtg gtg gtg gtg gtg gtg gtg gtg gtg gtg gtg gtg Val gtg gtg gtg gtg gtg ttt ttc att tcc act gtg act act 595 • Wing Gln Val Phe Val Wing Leu Pro Phe Phe He Thr Thr Thr Thr Thr 150 155 160 165 gca ctg cgt ggc att cca aaa cag ttt gag gaa ate gca gct act gaa 643 20 Wing Leu Arg Gly He Pro Lys Gln Phe Glu Glu He Ala Wing Thr Glu 170 175 180 ggc gca acc cgc tgg gag ate atg falls aag atg ate att ccg ctg gcg 691 Gly Wing Thr Arg Trp Glu He Met His Lys Met He He Pro Leu Ala 185 190 195 atg cct gga att ttc acc ggt atg att ttg gga tcc gcc agg gcc ttg 739 Met Pro Gly He Phe Thr Gly Met He Leu Gly Phe Ala Arg Ala Leu 200 205 210 ggc gag tat ggt gcg here ctg act ttt gct gga aat att gca ggt gtt 787 Gly Glu Tyr Gly Wing Thr Leu Thr Phe Wing Gly Asn He Wing Gly Val 215 220 225 acc cgc acc att ccg ttg cat att gag ctt ggt ttg agt tcc aat gac 835 2 Thr Arg Thr He Pro Leu His He Glu Leu Gly Leu Be Ser Asn Asp 230 235 240 245 atg gat aaa gcc ttg gga gcg gtg att atg ctt ttg gct gtc tat gtc 883 Met Asp Lys Ala Leu Gly Ala Val He Met Leu Leu Ala Val Tyr Val 250 255 260 etc ate att gga gcc ate gga gcg tta cga ttg ttt tcg aag gtg aga 931 Leu He He Gly Wing He Gly Wing Leu Arg Leu Phe Ser Lys Val Arg 265 270 275 aag gtt taattgatgt ctcgttcgcc gga 960 Lys Val < 210 > 658 < 211 > 279 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 658 Met Val Leu Ala Gln Thr Lys Lys Ala Arg Arg Ser Glu Asn His He 1 5 10 15 Leu Pro Gly Trp Leu Leu He Pro Wing Thr Leu Wing Met Leu Leu He 10 20 25 30 He Gly Pro He Phe Ala Leu Leu Leu Gln He Pro Trp Asp Arg Ser 35 40 45 Trp Glu Leu Leu Thr Wing Pro Glu Ser Leu Gly Thr Wing Arg Leu Ser 50 55 60 He Gly Thr Ala Leu Phe Ser Thr Ala Leu Cys Ala He Val Gly Phe 65 70 75 80 Pro Leu Ala Leu Ala Leu His Leu Tyr Glu Arg Ser His Pro Arg Val 85 90 95 Thr Ser Val Leu Thr Val Leu Val Tyr Ala Pro Leu Val Leu Ser Pro 100 105 110 Val Val Ser Gly Leu Ala Leu Thr Phe Leu Trp Gly Arg Arg Gly Phe 15 115 120 125 Leu Gly Ser Trp Leu Asp Gln Val Gly Leu Pro He Wing Phe Thr Thr 130 135 140 Thr Wing Val Val Phe Wing Gln Val Phe Val Wing Leu Pro Phe Phe He 145 150 155 160 Ser Thr Val Thr Thr Wing Leu Arg Gly He Pro Lys Gln Phe Glu Glu 165 170 175 Wing Wing Thr Glu Gly Wing Thr Arg Trp Glu He Met His Lys Met 180 185 190 He He Pro Pro Leu Wing Met Pro Gly He Phe Thr Gly Met He Leu Gly 195 200 205 Ph e Wing Arg Wing Leu Gly Glu Tyr Gly Wing Thr Leu Thr Phe Wing Gly 20 210 215 220 Asn He Wing Gly Val Thr Arg Thr He Pro Leu His He Glu Leu Gly 225 230 235 240 Leu Ser Ser As Asp Met Asp Lys Ala Leu Gly Ala Val He Met Leu 245 250 255 Leu Ala Val Tyr Val Leu He He Gly Ala He Gly Ala Leu Arg Leu 260 265 270 Phe Ser Lys Val Arg Lys Val 275 < 210 > 659 < 211 > 594 25 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (1) .. (594) < 223 > RXN00193 < 220 > < 221 > misc_feature • < 222 > 11 < 223 > n indicates any nucleotide < 220 > < 221 > VARIANT < 222 > 4 < 223 > Xaa = Phe,, Ser, Tyr, < or Cys < 400 > 659 aaa gct ttc tnc caa cgc gaa ggt ttc ate tca gcc ttc ggt ttc acc 48 Lys Wing Phe Xaa Gln Arg Glu Gly Phe He Ser Wing Phe Gly Phe Thr 10 1 5 10 15 gtc etc gtg gtc ate gtc tcc gtg ate here gtc aac ate ttc gcc ttc 96 Val Leu Val Val He Val Ser Val He Thr Val Asn He Phe Wing Phe 20 25 30 • etc ttg gcg tgg ttg ctg acc cgc aaa etc cgc ggt acc aac ttt ttc 144 Leu Leu Wing Trp Leu Leu Thr Arg Lys Leu Arg Gly Thr Asn Phe Phe 35 40 45 cgc here gtc ttc ttt atg ccg aac ctt ate ggc ggc att gtg ctg ggt 192 Arg Thr Val Phe Phe Met Pro Asn Leu He Gly Gly He Val Leu Gly 50 55 60 tat acc tgg cag acc atg ate aac gcc gtg ctt tcg fall tat gcc acg 240 Tyr Thr Trp Gln Thr Met He Asn Wing Val Leu Ser His Tyr Wing Thr 15 65 70 75 80 act att age gcg gac tgg aaa ttc ggc tac gcc ggc etc ate atg cta 288 Thr He Ser Wing Asp Trp Lys Phe Gly Tyr Wing Gly Leu He Met Leu 85 90 95 ctt aac tgg cag etc ate ggc tac atg ate att tac ate gcc ggc 336 Leu Asn Trp Gln Leu He Gly Tyr Met Met He He Tyr He Wing Ala Gly 100 105 110 ctg caa aac gtc cca cca gag etc att gag gct gcc gaa etc gac ggc 384 Leu Gln Asn Val Pro Pro Glu Leu He Glu Ala Wing Glu Leu Asp Gly 115 120 125 gtc aac aag tgg gag atg ctg cgg gtc gtc act att ccg atg gtc atg 432 Val Asn Lys Trp Glu Met Leu Arg His Val Thr He Pro Met Met Val Met 20 130 135 140 cca tcc ate acc ate tgc etc ttt ttg act ttg tcg aac tcc ttt aag 480 Pro Ser He Thr He Cys Leu Phe Leu Thr Leu Ser Asn Ser Phe Lys 145 150 155 160 etc tcc gac cag aac ctg gcg ctg acc aac gcc gct cct gcc ggg caa 528 Leu Phe Asp Gln Asn Leu Wing Leu Thr Asn Gly Wing Pro Gly Gly Gln 165 170 175 act gag atg gtg gcg etc aac ate ate aac acg ctg ttt aac cgt atg 576 Thr Glu Met Val Ala Leu Asn He He Asn Thr Leu Phe Asn Arg Met 180 185 190 aat gtc gag ggc gtc ggt 594 Asn Val Glu Gly Val Gly 25 195 < 210 > 660 < 211 > 198 < 212 > PRT < 213 > Corynebacterium glutamicum < 220 > < 221 > VARIANT < 222 > 4 < 223 > Xaa = Phe, Ser, Tyr, or Cys < 400 > 660 Lys Wing Phe Xaa Gln Arg Glu Gly Phe He Ser Wing Phe Gly Phe Thr 1 5 10 15 Val Leu Val Val He Val Ser Val He Thr Val Asn He Phe Wing Phe 20 25 30 Leu Leu Wing Trp Leu Leu Thr Arg Lys Leu Arg Gly Thr Asn Phe Phe 35 40 45 Arg Thr Val Phe Phe Met Pro Asn Leu He Gly Gly He Val Leu Gly 50 55 60 Tyr Thr Trp Gln Thr Met He Asn Wing Val Leu Ser His Tyr Ala Thr 65 70 75 80 Thr He Ser Wing Asp Trp Lys Phe Gly Tyr Wing Gly Leu He Met Leu 85 90 95 Leu Asn Trp Gln Leu He Gly Tyr Met Met He He Tyr He Wing Gly 100 105 110 Leu Gln Asn Val Pro Pro Glu Leu He Glu Wing Ala Glu Leu Asp Gly 115 120 125 Val Asn Lys Trp Glu Met Leu Arg His Val Thr He Pro Met Val Met 130 135 140 Pro Ser He Thr He Cry Leu Phe Leu Thr Leu Ser Asn Ser Phe Lys 145 150 155 160 Leu Phe Asp Gln Asn Leu Wing Leu Thr Asn Gly Wing Pro Gly Gly Gln 165 170 175 Thr Glu Met Val Wing Leu Asn He He Asn Thr Leu Phe Asn Arg Met 180 185 190 Asn Val Glu Gly Val Gly 195 < 210 > 661 < 211 > 1053 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1030) < 223 > RXN01298 < 400 > 661 cttaaacgtc acettattta tgcattatgt tggtttcaga etegaacaat tcaattagaa 60 aacactaatc ggacatttag gtcacataac atttccgctc gtg tcc here tta att 115 Val Ser Thr Leu He 1 5 tet gaa ccc gag gtg gat aag cta cgt aaa cgt gcc aag aga tca agg 163 Ser Glu Pro Glu Val Asp Lys Leu Arg Lys Arg Ala Lys Arg Ser Arg 10 15 20 A ^ ^ < cgg here gaa tgg tgg ctt gcc gcc gca ctt ctt gcc cca aac ttg ctt 211 Arg Thr Glu Trp Trp Leu Wing Wing Wing Leu Leu Wing Pro Asn Leu Leu 25 30 35 etc ttg gcc ate ttt acg tat cgg cca ctg tta gat aac ttc cgg ttg 259 Leu Leu Wing He Phe Thr Tyr Arg Pro Leu Leu Asp Asn Phe Arg Leu 40 45 50 tcc ttt ttc aac tgg aac att tcc tcg ccc here ttc acc ttc att ggg 307 Being Phe Phe Asn Trp Asn Be Ser Being Pro Thr Be Thr Phe He Gly 55 60 65 ttt gat aac tac gtt gag ttc ttc act cgt agt gac act etc caa gtt 355 Phe Asp Asn Tyr Val Glu Phe Phe Thr Arg Ser Asp Thr Leu Gln Val 70 75 80 85 gtt tta aac acc gtc ate ttc acg gca tgt gct gtg ate gga tcg atg 403 Val Leu Asn Thr Val He Phe Thr Wing Cys Wing Val He Gly Ser Met 90 95 100 gtg etc ggt ttg etc ctg gcc atg ttg ttg gat cag aag ctt ttc ggc 451 Val Leu Gly Leu Leu Leu Wing Met Leu Leu Asp Gln Lys Leu Phe Gly 105 110 115 cgt aac ttt gtg cgt tcc atg gtg ttt gcc ccg ttt gtg att tcc ggt 499 Arg Asn Phe Val Arg Ser Met Val Phe Wing Pro Phe Val He Ser Gly 120 125 130 gct gcc att ggt gtt gct ttc cag ttc gtt ttt gac cct aat ttt ggt 547 Ala Ala He Gly Val Ala Phe Gln Phe Val Phe Asp Pro Asn Phe Gly 135 140 145 ttg gtt cag gac ttg ctg gga cgc ate ggc gtt gat tcg cca cag ttc 595 Leu Val Gln Asp Leu Leu Gly Arg He Gly Val Asp Ser Pro Gln Phe 150 155 160 165 tac caa aac cct aac tgg gca ttg ttc atg gtg acg ttc act ttc gtg 643 Tyr Gln Asn Pro Asn Trp Wing Leu Phe Met Val Thr Phe Thr Phe Val 170 175 180 tgg aag aac ttg ggc tac tcc ttt gtt ate tac ctg gct gca ttg cag 691 Trp Lys Asn Leu Gly Tyr Ser Phe Val He Tyr Leu Ala Wing Leu Gln 185 190 195 ggg cta aac aag ttg tet gag gcc gca ccg gtg gat ggc gcg age 739 Gly Leu Asn Lys Asp Leu Ser Glu Ala Wing Pro Val Asp Gly Wing Ser 200 205 210 gcg tgg here cgt ttt tgg aag gtt act ctt ccg cag ctt cgc cca acc 787 Wing Trp Thr Arg Phe Trp Lys Val Thr Leu Pro Gln Leu Arg Pro Thr 215 220 225 acg ttc ttc ctt tet att act gtc acg ctg aac tcg gtt cag gtc ttc 835 Thr Phe Phe Leu Ser He Thr Val Thr Leu Asn Ser Val Gln Val Phe 230 235 240 245 gac ate att falls acc atg act cgt ggt ggc ccc ttg ggt aac ggt acg 883 Asp He He His Thr Met Thr Arg Gly Gly Pro Leu Gly Asn Gly Thr 250 255 260 action acc ttg gtt tac cag gtg tac acc gag act ttc acc aac tat cgc 931 Thr Thr Leu Val Tyr Gln Val Tyr Thr Glu Thr Phe Thr Asn Tyr Arg 265 270 275 gcg gga tat ggt gca here ate gca acg att ttg ttc ctg ttg ctg ctg 979 Ala Gly Tyr Gly Ala Thr He Ala Thr He Leu Phe Leu Leu Leu Leu 280 285 290 att ate act gtt ate cag gtt cga tac atg gat aag gag aac aag cag 1027 He He Thr Val He Gln Val Arg Tyr Met Asp Lys Glu Asn Lys Gln 295 300 305 aaa tgatctc? Rae t: cat Lgaaac gtt 1053 Lys 310 -dkÍi «iM_ _____________ llÉtftaUttl ^ Ídi < 210 > 662 < 211 > 310 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 662 Val Ser Thr Leu He Ser Glu Pro Glu Val Asp Lys Leu Arg Lys Arg 1 5 10 15 Wing Lys Arg Ser Arg Arg Thr Glu Trp Trp Leu Wing Wing Wing Leu Leu 20 25 30 Wing Pro Asn Leu Leu Leu Wing He Phe Thr Tyr Arg Pro Leu Leu 35 40 45 Asp Asn Phe Arg Leu Be Phe Phe Asn Trp Asn Be Ser Pro Thr 50 55 60 Be Thr Phe He Gly Phe Asp Asn Tyr Val Glu Phe Phe Thr Arg Ser 65 70 75 80 Asp Thr Leu Gln Val Val Leu Asn Thr Val He Phe Thr Ala Cys Wing 85 90 95 Val He Gly Ser Met Val Leu Gly Leu Leu Leu Wing Met Leu Leu Asp 100 105 110 Gln Lys Leu Phe Gly Arg Asn Phe Val Arg Ser Met Val Phe Wing Pro 115 120 125 Phe Val He Ser Gly Wing Wing He Gly Val Wing Phe Gln Phe Val Phe 130 135 140 Asp Pro Asn Phe Gly Leu Val Gln Asp Leu Leu Gly Arg He Gly Val 145 150 155 160 Asp Ser Pro Gln Phe Tyr Gln Asn Pro Asn Trp Wing Leu Phe Met Val 165 170 175 Thr Phe Thr Phe Val Trp Lys Asn Leu Gly Tyr Ser Phe Val He Tyr 180 185 190 Leu Ala Ala Leu Gln Gly Leu Asn Lys Asp Leu Ser Glu Ala Ala Pro 195 200 205 V al Asp Gly Ala Be Wing Trp Thr Arg Phe Trp Lys Val Thr Leu Pro 210 215 220 Gln Leu Arg Pro Thr Thr Phe Phe Leu Ser He Thr Val Thr Leu Asn 225 230 235 240 Ser Val Gln Val Phe Asp He He His Thr Met Thr Arg Gly Gly Pro 245 250 255 Leu Gly Asn Gly Thr Thr Leu Val Tyr Gln Val Tyr Thr Glu Thr 260 265 270 Phe Thr Asn Tyr Arg Wing Gly Tyr Gly Wing Thr He Wing Thr He Leu 275 280 285 Phe Leu Leu Leu Leu He He Thr Val He Gln Val Arg Tyr Met Asp 290 295 300 Lys Glu Asn Lys Gln Lys 305 310 < 210 > 663 < 211 > 1182 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1159) < 223 > RXA01737 ~ > ? .t ?? r. < 400 > 663 ctttgag, ccg aacg, atet, ge cgactcaag, a ag, aact, agee cggctgctca gtcaggaatg 60 atgicgcctaa gatcaaacaa gaatgaaagg aciggtgaaca atg ggc cga atg aaa 115 Met Gly Arg Met Lys 1 5 aac gat ggt gaa etc gcg gat ctg ccg gat cat gca ctt ttg age att 163 Asn Asp Gly Glu Leu Wing Asp Leu Pro Asp His Wing Leu Leu Ser He 10 15 20 att cga ate ccg cag gcg gcg aaa aga age ccc tgg gcg ctg ate tta 211 He Arg He Pro Gln Wing Wing Lys Arg Ser Pro Trp Wing Leu He Leu 25 30 35 acg cgc ate gga tac gcg atg gtg ctg ctg gt ate gtc acc atg gtt 259 Thr Arg He Gly Tyr Wing Met Val Leu Leu Val He Val Thr Met Val 40 45 50 gtc tat ttt gac cgc aac gga tac tc gaa gac etc acg ttc ate gac 307 Val Tyr Phe Asp Arg Asn Gly Tyr Ser Glu Asp Leu Thr Phe He Asp 55 60 65 gcg ttg tac tat tcc here gtc tcg ttg acc acc gtg ggc tac ggc gat 355 Ala Leu Tyr Tyr Ser Thr Val Ser Leu Thr Thr Val Gly Tyr Gly Asp 10 7O 75 80 85 ate acc ccg gtg acg caa tcg gca cgc ctc ate ate ate gtc etc 403 He Thr Pro Val Thr Gln Ser Wing Arg Leu He Asn He He Val Leu 90 95 100 • acc cca gca cgc ate ggc ttc ctg ate etc ctg gtc ggc acc acc ttg 451 Thr Pro Wing Arg He Gly Phe Leu He Leu Leu Val Gly Thr Thr Leu 105 110 115 tca gtg etc acc gaa gac tcg cgc cgg gcc ctg caa ate caa cgt tgg 499 Ser Val Leu Thr Glu Glu Be Arg Arg Ala Leu Gln He Gln Arg Trp 120 125 130 aga aaa cgc atg cgc aac falls acc gtc gtt gtc gga tac gga acc aaa 547 Arg Lys Arg Met Arg Asn His Thr Val Val Val Gly Tyr Gly Thr Lys 15 135 140 145 ggt cgc tcc gcg gtc gct gca ctg ctt ggc gac ggc gtc ccc gcc aac 595 Gly Arg Ser Wing Val Ala Wing Leu Leu Gly Asp Gly Val Pro Wing Asn 150 155 160 165 cag ate gtt gtt ate gac acc gat gtc gcc tcc etc gac gcc gcc aac 643 Gln He Val Val He Asp Thr Asp Gln Val Ser Leu Asp Ala Wing Asn 170 175 180 aac age gga etc gtc acc gtc aaa ggc tcc gcc acc aaa gca gat gtg 691 Asn Ser Gly Leu Val Thr Val Lys Gly Ser Wing Thr Lys Wing Asp Val • 185 190 195 ttg cgt cta gct ggc gtg tca cga gcg cgc gcc gtc gtc gtg gca ccg 739 Leu Arg Leu Ala Gly Val Ser Arg Ala Arg Ala Val Val Val Ala Pro 20 200 205 210 aac ctg gac gat act gca gtt ctg gtg act cta tcg gtg cga gaa ate 787 Asn Leu Asp Asp Thr Ala Val Leu Val Thr Leu Ser Val Arg Glu He 215 220 225 gcg ccg cag gca atg att gtg gcc agt gtc cga gaa tet gaa aac caa 835 Wing Pro Gln Wing Met He Val Wing Ser Val Arg Glu Ser Glu Asn Gln 230 235 240 245 falls etc etc gaa caa tcc ggt gcg gac tcg gtt gtg ate tcc tca gaa 883 His Leu Leu Glu Gln Ser Gly Wing Asp Ser Val Val He Ser Ser Glu 250 255 260 ac gct ggc cg atg etc ggt ctg gca here gtt acc cca tcg gtt gtg 931 Thr Ala Gly Arg Met Leu Gly Leu Ala Thr Val Thr Pro Ser Val Val 25 265 270 275 M ^ J ^ Á if t ^ í ^ gag atg gag gac etc etc tca ccc gac gaga gga ttc tcc gtt gcc 979 Glu Met Met Glu Asp Leu Leu Ser Pro Asp Glu Gly Phe Ser Val Ala 280 285 290 gaa cga cta gtc ggt gag gat gaa ate ggc tcc aac cca cga cga drops etc 1027 Glu Arg Leu Val Gly Glu Aslu Glu He Gly Ser Asn Pro Arg His Leu 295 300 305 gct gac ate gtc etc ggt gtt gtt cga cg tg ggt gag etc tac cgc ate 1075 Wing Asp He Val Leu Gly Val Val Arg Ser Gly Glu Leu Tyr Arg He 310 315 320 325 gac tcc cca gaa gca gaa act gta gag ccc ggc gat cgt etc ctt tac 1123 Asp Ser Pro Glu Ala Glu Thr Val Glu Pro Gly Asp Arg Leu Leu Tyr 330 335 340 gtt cgc cga gta ttt age gag gag gta aat gac aga tgagaattct 1169 Val Arg Arg Val Phe Ser Glu Glu Val Asn Asp Lys 345 350 tcccatcggc ccc 1182 < 210 > 664 < 211 > 353 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 664 Met Gly Arg Met Lys Asn Asp Gly Glu Leu Wing Asp Leu Pro Asp His 1 5 10 15 Wing Leu Leu Ser He He Arg He Pro Gln Wing Wing Lys Arg Ser Pro 20 25 30 Trp Wing Leu He Leu Thr Arg He Gly Tyr Wing Met Val Leu Leu Val 35 40 45 He Val Thr Met Val Val Tyr Phe Asp Arg Asn Gly Tyr Ser Glu Asp 50 55 60 Leu Thr Phe He Asp Ala Leu Tyr Tyr Ser Thr Val Ser Leu Thr Thr 65 70 75 80 Val Gly Tyr Gly Asp He Thr Pro Val Thr Gln Ser Ala Arg Leu He 85 90 95 Asn He He Val Leu Thr Pro Ala Arg He Gly Phe Leu He Leu Leu 100 105 110 Val Gly Thr Thr Leu Ser Val Leu Thr Glu Glu Ser Arg Arg Ala Leu 115 120 125 Gln He Gln Arg Trp Arg Lys Arg Met Arg Asn His Thr Val Val Val 130 135 140 Gly Tyr Gly Thr Lys Gly Arg Ser Wing Val Ala Wing Leu Leu Gly Asp 145 150 155 160 Gly Val Pro Wing Asn Gln He Val Val He Asp Thr Asp Gln Val Ser 165 170 175 Leu Asp Ala Ala Asn Asn Ser Gly Leu Val Thr Val Lys Gly Ser Wing 180 185 190 Thr Lys Wing Asp Val Leu Arg Leu Wing Gly Val Ser Arg Ala Arg Wing 195 200 205 Val Val Val Ala Pro Asn Leu Asp Asp Thr Wing Val Leu Val Thr Leu 210 215 220 Ser Val Arg Glu He Wing Pro Gln Wing Met He Val Wing Ser Val Arg 225 230 235 240 Glu Ser Glu Asn Gln His Leu Leu Glu Gln Ser Gly Wing Asp Ser Val 245 250 255 Val He Ser Ser Glu Thr Wing Gly Arg Met Leu Gly Leu Wing Thr Val 260 265 270 ^ L ^ j ^^ ATU Thr Pro Ser Val Val Glu Met Met Leu Leu Glu Asp Ser Pro Glu Asp Gly Phe 275 280 285 Ser Glu Ala Val Leu Arg Gly Val Glu Asp Ser Gly Glu He Asn Pro 290 295 300 Arg His Leu Ala Asp He Val Leu Gly Val Val Arg Ser Gly 305 310 315 320 Glu Leu Tyr Arg He Asp Ser Pro Glu Ala Glu Thr Val Glu Pro Gly 325 330 335 Asp Arg Leu Leu Tyr Val Arg Arg Val Phe Ser Glu Glu Val Asn Asp 340 345 350 Lys < 210 > 665 < 211 > 2007 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1984) < 223 > RXN02348 < 400 > 665 aaagaccega < gccgaagccc t < ggccltgcgc atacttcctt gtcaacgctc gctgggatta 60 ggtt? ttttCt < gagetgctatge atttctccac tcaaaggagc atg ctt aac cgc atg 115 Met Leu Asn Arg Met 1 5 aaa agt gcg cgg cca aaa tca gtc gct cc aaa tcc gga caa gct tta 163 Lys Ser Ala Arg Pro Lys Ser Val Ala Pro Lys Ser Gly Gln Ala Leu 10 15 20 etc. act etc ggt gcc gt gtt gtg gtc gtc gcc gac ate ggc acc age 211 Leu Thr Leu Gly Wing Leu Gly Val Val Phe Gly Asp He Gly Thr Ser 2 255 30 35 cccccc ccttgg ttaacc ttccaa cctttt falls act gca ttc age atg cag falls aac aaa gtc 259 P Prroo L Leeuu T Tyyrr S Seerr L Leeuu His Thr Wing Phe Ser Met Gln His Asn Lys Val 4400 45 50 ggaaaa ggttcc aacctt ccaagg ggaaaa aat gtg tac ggc ate ate tcc atg gtg ttg tgg 307 Glu Val Thr Gln Glu Asn Val Tyr Gly He He Ser Met Val Leu Trp 55 60 65 acc ate act ttg ate gtc acc gtc aaa tac gtc atg ctg gtc acc cga 355 Thr He Thr Leu He Val Thr Val Lys Tyr Val Met Leu Val Thr Arg 70 75 80 85 gct gac aac gga caa caa ggt ggc gcg ate ctg ttg ctg gct gtt etc 403 Ala Gly Asp Asn Gln Gln Gly Gly Leu Ala Val Leu He Leu Leu Ala 90 95 10 0 aaa aac cgt ggg falls tgg gga aaa ttc gtg gca gta ggc ggc atg ttg 451 Lys Asn Arg Gly His Trp Gly Lys Phe Val Wing Val Wing Gly Met Leu 105 110 115 ggc gcc gca ttg ttt tat ggc gat gtg gtg ate acc ccg gcg ate tet 499 Gly Wing Ala Leu Phe Tyr Gly Asp Val Val He Thr Pro Wing He Ser 120 125 130 gtt etc age gca here gaa ggc ttg acg gtt ate tcc cca age ttt gag 547 Val Leu Ser Ala Thr Glu Gly Leu Thr Val I Ser Ser Pro Phe Glu 135 140 145 cgc ttc att ctg ccc gta tet etc gca gtt ctg ate gct att ttt gca 595 Arg Phe He Leu Pro Val Ser Leu Ala Val Leu He Ala He Phe Ala 150 155 160 165 ate caa ccg etc ggt here gaa aaa gtc ggc aaa gcc ttc ggc ccc ate 643 He Gln Pro Leu Gly Thr Glu Lys Val Gly Lys Wing Phe Gly Pro He 170 175 180 atg ttg ctg tgg ttt gtc gtc acc gtc gga ttg gga att ccg caa ate 691 Met Leu Leu Trp Phe Val Thr Leu Ala Gly Leu Gly He Pro Gln I 185 190 195 ate ggg falls cca gaa ate ttg cag age ttg tet cca cat tgg gcc ctg 739 He Gly His Pro Glu He Leu Gln Ser Leu Ser Pro His Ala Trp Leu 200 205 210 cgc att ttg gct gtg gag cct gca caa ttc ttt gtg ctg ctt ggt gcc 787 Arg Leu Ala Glu Pro Val He Phe Gln Leu Leu Ala Phe Val Gly Ala 215 220 225 gtt gtc gtc ctg here gta ggt ggt gcg gaa gcg gtc gcg gtc gtc gtc 835 Val Val Leu Thr Val Thr Gly Ala Glu Ala Leu Tyr Ala Asp Met Gly 230 235 240 245 cat ttt ggg gcg agg cca gtg aga gtg gtg tgg ttt tgc gtc gtc gtc atg 883 His Phe Gly Wing Arg Pro He Arg Val Wing Trp Phe Cys Val Val Met 250 255 260 cct gct tta ate ttg acg tat ttg ggg cag ggc gcc ttg gtg ate aac 931 Pro Ala Leu He Leu Thr Tyr Leu Gly Gln Gly Wing Leu Val He Asn 265 270 275 cag cct gaa gcg gtg cgc aac ccc atg ttt tat etc gcg ccg gaa ggt 979 Gln Pro Glu Wing Val Arg Asn Pro Met Phe Tyr Leu Wing Pro Glu Gly 280 285 290 ctg cgg att ccg ttg gtt att ttg gcg acc ate ggcctt aaccgg ggttgg aattee ggccaa 1027 Leu Arg He Pro Leu Val He Leu Ala Thr He Ala Thr Val He Ala 295 300 305 tcg cag gcc gtg att tet ggt gcg tat tca ttg aacccc aaaagg ccaagg ggcccc ggttgg 1075 Ser Gln Wing Val He Ser Gly Wing Tyr Ser Leu Thr Lys Gln Wing Val 310 315 320 325 aat ttg aaa ctg ctg cca cgc atg gtg ate cgg ccaatt aacccc ttcccc ccggcc aaaaaa 1123 Asn Leu Lys Leu Leu Pro Arg Met Val He Arg His Thr Ser Arg Lys 330 335 340 gag gag ggc cag ate tat atg cca ctg gtt aat gga ttg ctg ttt gta 1171 Glu Glu Gly Gln He Tyr Met Pro Leu Val Asn Gly Leu Leu Phe Val 345 350 355 tcc gtg atg gtt gtg gtg ctg gta ttc cga tcc tet gaa age etc gcc 1219 Val Val Val Leu Val Val Val Phe Arg Ser Ser Glu Ser Leu Ala 360 365 370 age gcg tac gga ctt gca gtg acc gga acc ttg gtg ctg gtc age gtc 1267 Be Ala Tyr Gly Leu Ala Val Thr Gly Thr Leu Val Leu Val Ser Val 375 380 385 ctg tat ctg ate tat gtt falls acc tà tgg tgg aaa here gcg ctg ttc 1315 Leu Tyr Leu He Tyr Val His Thr Thr Trp Trp Lys Thr Ala Leu Phe 390 395 400 405 att gtg etc ate ggt att cca gaa gta ctt cta tcc gcc tcg aac acc 1363 He Val Leu He Gly He Pro Glu Val Leu Leu Phe Wing Ser Asn Thr 410 415 420 acg aaa att falls gac ggt ggc tgg ctt cca cta ctt att gcg gcc gtg 1411 Thr Lys He His Asp Gly Gly Trp Leu Pro Leu Leu He Wing Wing Val 425 430 435 etc ate gtg gtg atg cgg acc tgg gag tgg gga agt gac cgc gtc aat 1459 Leu He Val Val Met Arg Thr Trp Glu Trp Gly Ser Asp Arg Val Asn 440 445 450 cag gaa cgc gg gag ctg gaa ctt ccc ccc atg gat aag ttc ttg gag aaa 1507 Gln Glu Arg Wing Glu Leu Glu Leu Pro Met Asp Lys Phe Leu Glu Lys 455 460 465 etc. gat cag cca falls aat att ggt ctg cgt aaa gtt gcc gaa gtg gca 1555 Leu Asp Gln Pro His Asn He Gly Leu Arg Lys Val Wing Glu Val Wing 470 475 480 485 gta ttt cca cat ggc acc age gat act gtc ccg ttg tca ttg gtt cgc 1603 Val Phe Pro His Gly Thr Ser Asp Thr Val P ro Leu Ser Leu Val Arg 490 495 500 tgc gtg aaa gac etc aag ctt tta tac cga gag ate gtg ate gtt cga 1651 Cys Val Lys Asp Leu Lys Leu Leu Tyr Arg Glu He Val He Val Arg 505 510 515 ate gtc caa gaa cae gtt ccg falls gtg cca cca gag gag cgc gcg gaa 1699 He Val Gln Glu His Val Pro His Val Pro Pro Glu Glu Arg Ala Glu 520 525 530 atg gaa gtg etc cat falls gcc ccg ate aga gtc gtg cga gtt gat ctg 1747 Met Glu Val Leu His His Wing Pro He Arg Val Val Arg Val Asp Leu 535 540 545 fall ctt ggt tat ttt gat gag cag aac ctg cct gag cat etc cat gcc 1795 His Leu Gly Tyr Phe Asp Glu Gln Asn Leu Pro Glu His Leu His Wing 550 555 560 565 att gac cca here tgg gat aac gcc acc tac ttc ctg tet gcc ctg act 1843 He Asp Pro Thr Trp Asp Asn Wing Thr Tyr Phe Leu Ser Wing Leu Thr 10 570 575 580 ctt cgg age agg ttg cct gga aag att gct ggc tgg cgt gat cgt ttg 1891 Leu Arg Be Arg Leu Pro Gly Lys He Wing Gly Trp Arg Asp Arg Leu 585 590 595 • tat ctt tcg atg gaa cgt aat cag gca tet cga act gag tet ttc aaa 1939 Tyr Le u Ser Met Glu Arg Asn Gln Wing Being Arg Thr Glu Being Phe Lys 600 605 610 ttg caa cca age aaa acc ate acg gtt gga here gag ctg falls ctt 1984 Leu Gln Pro Ser Lys Thr He Thr Val Gly Thr Glu Leu His Leu 615 620 625 taatcaggca gttgctggcc aac 2007 15 < 210 > 666 < 211 > 628 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 666 Met Leu Asn Arg Met Lys Ser Wing Arg Pro Lys Ser Val Wing Pro Lys 1 5 10 15 Ser Gly Gln Wing Leu Leu Thr Leu Gly Wing Leu Gly Val Val Phe Gly • 20 25 30 Asp He Gly Thr Ser Pro Leu Tyr Ser Leu His Thr Wing Phe Ser Met 35 40 45 20 Gln His Asn Lys Val Glu Val Thr Gln Glu Asn Val Tyr Gly He He 50 55 60 Ser Met Val Leu Trp Thr He Thr Leu He Val Thr Val Lys Tyr Val 65 70 75 80 Met Leu Val Thr Arg Wing Asp Asn Gln Gly Gln Gly Gly He Leu Wing 85 90 95 Leu Val Wing Leu Leu Lys Asn Arg Gly His Trp Gly Lys Phe Val Wing 100 105 110 Val Wing Gly Met Leu Gly Wing Ala Leu Phe Tyr Gly Asp Val Val He 115 120 125 Thr Pro Wing He Ser Val Leu Ser Wing Thr Glu Gly Leu Thr Val He 130 135 140 25 Ser Pro Ser Phe Glu Arg Phe He Leu Pro Val Ser Leu Ala Val Leu 145 150 155 160 He Wing He Phe Wing He Gln Pro Leu Gly Thr Glu Lys Val Gly Lys 165 170 175 Wing Phe Gly Pro He Met Leu Leu Trp Phe Val Thr Leu Wing Gly Leu 180 185 190 Gly He Pro Gln He He Gly His Pro Glu He Leu Gln Ser Leu Ser 195 200 205 Pro His Trp Ala Leu Arg Leu He Val Ala Glu Pro Phe Gln Wing Phe 210 215 220 Val Leu Leu Gly Wing Val Val Leu Thr Val Thr Gly Ala Glu Ala Leu 225 230 235 240 Tyr Ala Asp Met Gly His Phe Gly Ala Arg Pro He Arg Val Ala Trp 245 250 255 Phe Cys Val Val Met Pro Ala Leu He Leu Thr Tyr Leu Gly Gln Gly 260 265 270 Wing Leu Val He Asn Gln Pro Glu Wing Val Arg Asn Pro Met Phe Tyr 275 280 285 Leu Wing Pro Glu Gly Leu Arg He Pro Leu Val He Leu Ala Thr He 290 295 300 Wing Thr Val He Wing Wing Gln Wing Val He Ser Gly Wing Tyr Ser Leu 305 310 315 320 Thr Lys Gln Ala Val Asn Leu Lys Leu Leu Pro Arg Met Val He Arg 325 330 335 His Thr Ser Arg Lys Glu Glu Gly Gln He Tyr Met Pro Leu Val Asn 340 345 350 Gly Leu Leu Phe Val Ser Val Val Val Val Leu Val Phe Arg Ser 355 360 365 Ser Glu Ser Leu Ala Ser Ala Tyr Gly Leu Ala Val Thr Gly Thr Leu 370 375 380 Val Leu Val Ser Val Leu Tyr Leu He Tyr Val His Thr Thr Trp Trp 385 390 395 400 Lys Thr Ala Leu Phe He Val Leu He Gly He Pro Glu Val Leu Leu 405 410 415 Phe Ala Ser Asn Thr Thr Lys He His Asp Gly Gly Trp Leu Pro Leu 420 425 430 Leu He Wing Wing Val Leu He Val Val Met Arg Thr Trp Glu Trp Gly 435 440 445 Ser Asp Arg Val Asn Gln Glu Arg Wing Glu Leu Glu Leu Pro Met Asp 450 455 460 Lys Phe Leu Glu Lys Leu Asp Gln Pro His Asn He Gly Leu Arg Lys 465 470 475 480 Val Ala Glu Val Ala Val Phe Pro His Gly Thr Ser Asp Thr Val Pro 485 490 495 Leu Ser Leu Val Arg Cys Val Lys Asp Leu Lys Leu Leu Tyr Arg Glu 500 505 510 He Val He Val Arg He Val Gln Glu His Val Pro His Val Pro Pro 515 520 525 Glu Glu Arg Ala Glu Met Glu Val Leu His His Wing Pro He Arg Val 530 535 540 Val Arg Val Asp Leu His Leu Gly Tyr Phe Asp Glu Gln Asn Leu Pro 545 550 555 560 Glu His Leu His Wing He Asp Pro Thr Trp Asp Asn Wing Thr Tyr Phe 565 570 575 Leu Be Ala Leu Thr Leu Arg Be Arg Leu Pro Gly Lys He Wing Gly 580 585 590 Trp Arg Asp Arg Leu Tyr Leu Ser Met Glu Arg Asn Gln Wing Be Arg 595 600 605 Thr Glu Be Phe Lys Leu Gln Pro Ser Lys Thr He Thr Val Gly Thr 610 615 620 Glu Leu His Leu 625 < 210 > 667 < 211 > 1656 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1633) < 223 > RXA02426 < 400 > 667 tgcagcatgca 1taatt: aggga aaaat; aggaa ctgttt; actg aaaactgac; aaacctgaca 60 gacctgat 2CC tgaagagacct tattcatgac gal: attgttc atg etc att here ttg 115 Met Leu He Thr Leu 1 5 10 ctg etc gcc acc gtg att gtg gtg gcc ate ggc gat aaa acc gga etc 163 Leu Leu Wing Thr Val He Val Val Wing He Gly Asp Lys Thr Gly Leu 10 15 20 ccc tgg cct gct ttg atg act att gtc gcc gca ggt gga gcg ttg ttg 211 • Pro Trp Pro Wing Leu Met Thr He Val Wing Wing Gly Gly Wing Leu Leu 25 30 35 cca ttt ttg ccg gaa ttt act ate ccg gcc gat ctg atg ttg cct att 259 Pro Phe Leu Pro Glu Phe Thr He Pro Wing Asp Leu Met Leu Pro He 40 45 50 ttc att ccg ccg ctg ctg tgg gcg ctg gcg agg aag tca tcg tgg gcg 307 Phe He Pro Pro Leu Leu Trp Wing Leu Wing Arg Lys Ser Ser Trp Wing 55 60 65 15 gtg att agg tcg cag atg tet acc ate ate atg tcg gtg ttg ttg 355 Val He Arg Ser Gln Met Ser Thr He He Thr Met Ser Val Leu Leu 70 75 80 85 gtg ttc gtg acc ate gcg gca etc acg ggt gca tcc atg ctg ttg ctt 403 Val Phe Val Thr He Ala Ala Leu Thr Gly Ala Ser Met Leu Leu Leu 90 95 100 cct ggc att ggt ctt gct ggt gcg ate atg ttg gct gcg gct att gct 451 Pro Gly He Gly Leu Wing Gly Wing He Met Leu Wing Wing Wing He Wing 105 110 115 • cca ccg gat cct gtt gct gtt gat gca gtg gcg gaa cct gcg gga ate 499 Pro Pro Asp Pro Val Wing Val Asp Wing Val Wing Glu Pro Wing Gly He 120 125 130 20 ccg aag cgc ate acc acc ttg action acg gag ggt ctg ttt aat gat 547 Pro Lys Arg He Thr Thr Thu Leu Gln Thr Glu Gly Leu Phe Asn Asp 135 140 145 gca gcc age ate gtg gcg gtg cat gtg gct tta gct gcc gtc gtc cct gct 595 Ala Ala Ser He Val Ala Phe His Val Ala Leu Ala Ala Leu Val Ala 150 155 160 165 ggt gag gat ttg tcc tgg tca acg ggt gtt ttg gaa ttc ttg tgg tcg 643 Gly Glu Asp Leu Ser Trp Ser Thr Gly Val Leu Glu Phe Leu Trp Ser 170 175 180 tgt ctt gct gcc gtt att ttg ggc ttg gtt att ggc cgg gcg gct gcg 691 Cys Leu Wing Wing Val He Leu Gly Leu Val Wing Gly Arg Wing Wing Wing 185 190 195 25 tgg ttt acc gat falls gtg agt tcc gtt gag gct cga aat gcg ttt acg 739 «.-?.? to ? ? Trp Phe Thr Asp His Val Ser Ser Val Glu Wing Arg Asn Wing Phe Thr 200 205 210 tgg gtg ctg ccg ttt gcc att tat gtg gtg gcg gaa gaa ate ggc gga 787? Rp Val Leu Pro Phe Ala He Tyr Val Val Ala Glu Glu He Gly Gly 215 220 225 tcg ggc gtt ate gcc att gtg ate gct gca gtg gag atg aat tcg agg 835 Ser Gly Val He Wing He Val Wing Ala Wing Val Glu Met Asn Ser Arg 230 235 240 245 gcg ttccgg aatttt ggggtt ggccgg gag gat cgt cta acg ggt tet gcg ttc tgg gga 883 • Wing Being He Gly Wing Glu Asp Arg Leu Thr Gly Being Wing Phe Trp Gly 250 255 260 acc att gag gtg ctg ttt act ggc gtt gcc ttt ggt ttg ate ggc ctg 931 Thr He Glu Val Leu Phe Thr Gly Val Wing Phe Gly Leu He Gly Leu 265 270 275 aat gtg cgc gct gcg att gat gaa gtt gga tet gag ctg tgg cat gcc 979 Asn Val Arg Ala Wing Asp Glu Val Gly Ser Glu Leu Trp His Wing 280 285 290 gtg gtc gtg ggc att gtg etc tcg gtg gtg gcg ate gtt gtc cgt ggt 1027 Val Val Val Gly He Val Leu Ser Val Val Ala He Val Val Arg Gly 295 300 305 10 gtg tgg atg ttc gcg gcg tat aag cgc aat cgt ttc aag ate gat aag 1075 Val Trp Met Phe Ala Ala Tyr Lys Arg Asn Arg Phe Lys He Asp Lys 310 315 320 325 aag ggt gcg acc aat agt tca ttg cgg gcg cct ctt cga cg cag gaa 1123 • Lys Gly Ala Thr Asn Ser Ser Leu Arg Ala Pro Leu Arg Leu Gln Glu 330 335 340 tcg ttg ctg atg acg tgg gcg ggc atg cgc ggt ttg gtg acg ttg gcg 1171 Ser Leu Leu Met Thr Trp Wing Gly Met Arg Gly Leu Val Thr Leu Wing 345 350 355 ctg gtg ctg tet att ccg gag gat att ttc ccg tat falls drops gag ttg 1219 Leu Val Leu Ser He Pro Glu Asp He Phe Pro Tyr His His Glu Leu 360 365 370 U cag gtc att gcg ctg gtc gtt etc tta ate acc atg gtg ggc cct ggt 1267 Gln Val He Ala Leu Val Val Leu Leu He Thr Met Val Gly Pro Gly 375 380 385 ttg acg ttg cg tgg ctg atg cgg aag etc age ttg gat aag ggt ccc 1315 Leu Thr Leu Pro Trp Leu Met Arg Lys Leu Ser Leu Asp Lys Gly Pro 390 395 400 405 gat gct gcg ggc gat gag agt ate gcc gcg ctg here gag agg gct drops 1363 Asp Ala Ala Gly Asp Glu Ser He Ala Ala Leu Thr Glu Arg Ala His 410 415 420 • aag gcc gca here acg tat ttg gtg gat acc acg gag ttg cgg atg gag 1411 Lys Ala Wing Thr Thr Tyr Leu Val Asp Thr Thr Glu Leu Pro Met Glu 425 430 435 20 cag atg gtg gcg ate aag aat tgg ttc tcg caa gaa att gac gct gat 1459 Gln Met Val Wing He Lys Asn Trp Phe Ser Gln Glu He Asp Wing Asp 440 445 450 gaa ctg cag gag aac gtc gat aag ctg cat cag cgc gcg cat cat gcg 1507 Glu Leu Gln Glu Asn Val Asp Lys Leu His Gln Arg Wing His His Wing 455 460 465 cgt gtc ggg gca gag gcg gcc gcg gcc cag gag gag ctg ttg aag gcg cgg 1555 Arg Val Gly Ala He Lys Ala Ala Gln Glu Glu Leu Leu Lys Ala Arg 470 475 480 485 cgg gag cgc ggc gtt aat ccg gcc tat gtt gat gag gtg ttg acc aac 1603 Arg Glu Arg Gly Val Asn Pro Wing Tyr Val Asp Glu Val Leu Thr Asn 490 495 500 25 att gac cgg atg ctt gtt gcg gct gaa cgc tagataaaca gcagcaggct 1653 g ^^ gügHi ^^ g He Asp Arg Met Leu Val Ala Ala Glu Arg 505 510 gat 1656 < 210 > 668 < 211 > 511 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 668 Met Leu He Thr Leu Leu Leu Wing Thr Val He Val Val Wing He Gly 1 5 10 15 Asp Lys Thr Gly Leu Pro Trp Pro Wing Leu Met Thr He Val Wing Wing 20 25 30 Gly Gly Wing Leu Leu Pro Phe Leu Pro Glu Phe Thr He Pro Wing Asp 35 40 45 Leu Met Leu Pro He Phe He Pro Pro Leu Leu Trp Wing Leu Wing Arg 50 55 60 Lys Ser Ser Trp Wing Val He Arg Ser Gln Met Ser Thr He He Thr 65 70 75 80 10 Met Ser Val Leu Leu Val Phe Val Thr He Ala Ala Leu Thr Gly Ala 85 90 95 Ser Met Leu Leu Pro Gly He Gly Leu Ala Gly Ala He Met Leu 100 105 110 Ala Ala Ala Ala Ala Pro Pro Asp Pro Val Ala Val Asp Ala Ala Wing 115 120 125 Glu Pro Wing Gly He Pro Lys Arg He Thr Thr Thu Leu Gln Thr Glu 130 135 140 Gly Leu Phe Asn Asp Wing Wing He Val Wing Phe His Val Wing Leu 145 150 155 160 Wing Wing Leu Val Wing Gly Glu Asp Leu Ser Trp Ser Thr Gly Val Leu 165 170 175 j < 5 Glu Phe Leu Trp Ser Cys Leu Wing Wing Val He Leu Gly Leu Val He 180 185 190 Gly Arg Wing Wing Wing Trp Phe Thr Asp His Val Ser Ser Val Glu Wing 195 200 205 Arg Asn Wing Phe Thr Trp Val Leu Pro Phe Wing He Tyr Val Val Wing 210 215 220 Glu Glu He Gly Gly Ser Gly Val He Wing He Val He Wing Wing Val 225 230 235 240 Glu Met Asn Ser Arg Ala Ser He Gly Ala Glu Asp Arg Leu Thr Gly 245 250 255 Ser Ala Phe Trp Gly Thr He Glu Val Leu Phe Thr Gly Val Ala Phe 260 265 270 0 Gly Leu He Gly Leu Asn Val Arg Ala Wing Asp Glu Val Gly Ser 275 280 285 Glu Leu Trp His Wing Val Val Val Gly He Val Leu Ser Val Val Ala 290 295 300 He Val Val Arg Gly Val Trp Met Phe Wing Wing Tyr Lys Arg Asn Arg 305 310 315 320 Phe Lys He Asp Lys Lys Gly Wing Thr Asn Ser Ser Leu Arg Wing Pro 325 330 335 Leu Arg Leu Gln Glu Ser Leu Leu Met Thr Trp Wing Gly Met Arg Gly 340 345 350 Leu Val Thr Leu Ala Leu Val Leu Ser He Pro Glu Asp He Phe Pro 355 360 365 5 Tyr His His Glu Leu Gln Val He Wing Leu Val Val Leu Leu He Thr ,? t í. 370 375 380 Met Val Gly Pro Gly Leu Thr Leu Pro Trp Leu Met Arg Lys Leu Ser 385 390 395 400 Leu Asp Lys Gly Pro Asp Wing Wing Gly Asp Glu Ser Wing Wing Wing Leu 405 410 415 Thr Glu Arg Wing His Lys Wing Wing Thr Thr Tyr Leu Val Asp Thr Thr 420 425 430 Glu Leu Pro Met Glu Gln Met Val Wing He Lys Asn Trp Phe Ser Gln 435 440 445 Glu He Asp Wing Asp Glu Leu Gln Glu Asn Val Asp Lys Leu His Gln 450 455 460 Arg Wing His His Wing Arg Val Gly Wing He Lys Wing Wing Gln Glu Glu 465 470 475 480 Leu Leu Lys Wing Arg Arg Glu Arg Gly Val Asn Pro Wing Tyr Val Asp 485 490 495 Glu Val Leu Thr Asn He Asp Arg Met Leu Val Wing Wing Glu Arg 500 505 510 < 210 > 669 < 211 > 993 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (970) < 223 > RXN03164 < 400 > 669 cttttttgca • tcca < gatgica caaagíccgtg gcacaaacga gacaaac? tga < gcacaatggc 60 tgtcatggca -tatcaaccag cagacaatctg ctatgat; gac atg ate tac cgc agg 115 Met He Tyr Arg Arg 1 5 gtg gga aat tet ggg ctg aag ctt ccg gca att tcg ctt ggg ctg tgg 163 Val Gly Asn Ser Gly Leu Lys Leu Pro Wing He Ser Leu Gly Leu Trp 10 15 20 falls aac ttc ggt gat gac aag ccg ctt tca acg cag cgc age att att 211 His Asn Phe Gly Asp Asp Lys Pro Leu Ser Thr Gln Arg Ser He He 25 30 35 falls cgc gcg ttt gat agg gga gtc act falls ttc gat ttg gct aat aac 259 His Arg Wing Phe Asp Arg Gly Val Thr His Phe Asp Leu Wing Asn Asn 40 45 50 tat gga cct cca gca ggt tcc gca gag acc aac ttt ggc agg att ttg 307 Tyr Gly Pro Pro Wing Gly Wing Wing Glu Thr Asn Phe Gly Arg He Leu 55 60 65 cgt gag gat etc aaa age falls cgc gat gag ttg ate att tet tcc aag 355 Arg Glu Asp Leu Lys Ser His Arg Asp Glu Leu He He Ser Ser Lys 70 75 80 85 gcg ggt tgg gat atg tgg cct gga cct tat ggt ttt ggt ggt tcc cga 403 Wing Gly Trp Asp Met Trp Pro Gly Pro Tyr Gly Phe Gly Gly Ser Arg 90 95 100 aag tat cta gtg agt tcc ctt gat cag tcc ctg act cgc etc ggc ttg 451 Lys Tyr Leu Val Ser Ser Leu Asp Gln Ser Leu Thr Arg Leu Gly Leu 105 110 115 gat tac gtg gat att ttc tat cat falls cgc ccg gat cca gat act cct 499 Asp Tyr Val Asp He Phe Tyr His His Arg Pro Asp Pro Asp Thr Pro 120 125 130 ttg gaa gaa acc atg tac gca ttg cgt gac att gtt gcg tet gga aag 547 Leu Glu Glu Thr Met Tyr Ala Leu Arg Asp He Val Wing Ser Gly Lys 135 140 145 gct ctt tac gtg gtt att tet tcc tac ggt cca gag etc here gcg gag 595 Ala Leu Tyr Val Gly He Ser Ser Tyr Gly Pro Glu Leu Thr Ala Glu 150 155 160 165 gcg gct gag ttc atg gcg gag gag ggc tgc ccg ctt ctg att cat cag 643 Ala Ala Glu Phe Met Ala Glu Glu Gly Cys Pro Leu Leu He His Gln 170 175 180 cca age tat tcc ate att aat cgt tgg gtg gag gaa ccg ggc gat gac 691 Pro Ser Tyr Ser He He Asn Arg Trp Val Glu Glu Pro Gly Asp Asp 185 190 195 ggt gag aac ttg ttg cag tca gct gcc aac aat ggt ctt ggc gtc att 739 Gly Glu Asn Leu Leu Gln Be Wing Wing Asn Asn Gly Leu Gly Val He 200 205 210 gct ttc tca cca ctt gcg cag ggc ctg etc acg gac aaa tat etc gat 787 Wing Phe Ser Pro Leu Wing Gln Gly Leu Leu Thr Asp Lys Tyr Leu Asp 215 220 225 gga att cca gag ggt tcc cgc gcc age cag ggt aag tcc ctg tet gag 835 Gly He Pro Glu Gly Ser Arg Ala Ser Gln Gly Lys Ser Leu Ser Glu 230 235 240 245 ggc atg ttg aac gtg aac aat att gat atg gtc cgc aag etc aat gac 883 Gly Met Leu Asn Val Asn Asn He Asp Met Val Arg Lys Leu Asn Asp 250 255 260 ate gcc cag gaa cgc ggg cag tca ctt gcg cag atg gcg ctt gca tgg 931 He Wing Gln Glu Arg Gly Gln Ser Leu Wing Gln Met Wing Leu Wing Trp 265 270 275 gtg ctg cgc gag caa aga gag tac ggc gcc gga tta ccg tgaccagtgc 980 Val Leu Arg Glu Gln Arg Glu Tyr Gly Wing Gly Leu Pro 280 285 290 attgattggt gct 993 < 210 > 670 < 211 > 290 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 670 Met He Tyr Arg Arg Val Gly Asn Ser Gly Leu Lys Leu Pro Wing He 1 5 10 15 Ser Leu Gly Leu Trp His Asn Phe Gly Asp Asp Lys Pro Leu Ser Thr 20 25 30 Gln Arg Ser He He His Arg Ala Phe Asp Arg Gly Val Thr His Phe 35 40 45 Asp Leu Ala Asn Asn Tyr Gly Pro Pro Wing Gly Wing Wing Glu Thr Asn 50 55 60 Phe Gly Arg He Leu Arg Glu Asp Leu Lys Ser His Arg Asp Glu Leu 65 70 75 80 He He Ser Ser Lys Wing Gly Trp Asp Met Trp Pro Gly Pro Tyr Gly 85 90 95 Phe Gly Gly Ser Arg Lys Tyr Leu Val Ser Ser Leu Asp Gln Ser Leu 100 105 110 Thr Arg Leu Gly Leu Asp Tyr Val Asp He Phe Tyr His His Arg Pro 115 120 125 Asp Pro Asp Thr Pro Leu Glu Glu Thr Met Tyr Ala Leu Arg Asp He 130 135 140 Val Ala Ser Gly Lys Ala Leu Tyr Val Gly He Ser Ser Tyr Gly Pro 145 150 155 160 Glu Leu Thr Wing Glu Wing Wing Glu Phe Met Wing Glu Glu Gly Cys Pro 165 170 175 Leu Leu He His Gln Pro Ser Tyr Ser He He Asn Arg Trp Val Glu 180 185 190 Glu Pro Gly Asp Asp Gly Glu Asn Leu Leu Gln Be Ala Ala Asn Asn 195 200 205 Gly Leu Gly Val He Ala Phe Ser Pro Leu Ala Gln Gly Leu Leu Thr 210 215 220 Asp Lys Tyr Leu Asp Gly He Pro Glu Gly Ser Arg Ala Ser Gln Gly 225 230 235 240 Lys Ser Leu Ser Glu Gly Met Leu Asn Val Asn Asn As Asp Met Val 245 250 255 Arg Lys Leu Asn Asp He Wing Gln Glu Arg Gly Gln Ser Leu Wing Gln 260 265 270 Met Ala Leu Ala Trp Val Leu Arg Glu Gln Arg Glu Tyr Gly Wing Gly 275 280 285 Leu Pro 290 <; 210 > 671 < 211 > 1068 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1045) < 223 > RXN00024 < 400 > 671 ttaagacatc aacatatggc ttgtgctact gaaagatttt tcttctgaaa ttctgtagaa 60 acgctcctat gctcggggca gtaagttgtg agcataggaa atg gag falls ggc gtg 115 Met Glu His Gly Val 1 5 acc gtt att aaa ggc act gaa ttt gat gtt tcc cca cta aac etc ggt 163 Thr Val He Lys Gly Thr Glu Phe Asp Val Phe Pro Leu Asn Leu Gly 10 15 20 gga aat acc ttt ggc tgg acc tcg aat agg gaa cag acc ttc gcg gtt 211 Gly Asn Thr Phe Gly Trp Thr Ser Asn Arg Glu Gln Thr Phe Ala Val 25 30 35 ttg gat gca ttc gtg gca gcg gga gga gga aac ttt gtt gac acc gcc gat 259 leu asp wing phe val wing wing gly gly asn phe val asp thr wing asp 40 45 50 tet tat tet gca tgg gtt gaa ggc aat gag ggt ggc gag tcg gag cgg 307 Being Tyr Being Wing Trp Val Glu Gly Asn Glu Gly Glu Glu Being Glu Arg 55 60 65 gag etc ggc gcg tgg att aag gaa cgt ggc gca gac aag ctg att att 355 Glu Leu Gly Wing Trp He Lys Glu Arg Gly Wing Asp Lys Leu He He 70 75 80 85 gct acc aag tet ggt gcg ttg gag cct gtt gct ggt cgt tcc cgt gag 403 Wing Thr Lys Ser Gly Wing Leu Glu Pro Val Wing Gly Arg Ser Arg Glu 90 95 100 gca act ttc aag gct ggc gag ggt tcc cg tg ggc tg ggg gaa 451 Wing Thr Phe Lys Wing Val Glu Gly Ser Leu Glu Arg Leu Gly Val Glu 105 110 115 tcg ate gat ttt tac tac tac tac tac gac gat gag gca gtc age att 499 '* * i Be He Asp He Phe Tyr Tyr His Tyr Asp Asp Glu Wing Val Ser He 120 125 130 gat gag cag gtt gct ate gct aat gat ctg att gca cag ggc aag att 547 Asp Glu Gln Val Wing He Wing Asn Asp Leu He Wing Gln Gly Lys He 135 140 145 aag falls etc gca ttg tet aac tac age gcg gag cgt tta gct gag ttc 595 Lys His Leu Ala Leu Ser Asn Tyr Ser Ala Glu Arg Leu Ala Glu Phe 150 155 160 165 ttt gag aag tet gta ggc act cca gcg cag ccg gtt gct ctg caa ccg 643 Phe Glu Lys Ser Val Gly Thr Pro Wing Gln Pro Val Wing Leu Gln Pro 170 175 180 falls tac aac ctg gtg tcg agg aag gat tat gag gag aac gtg cag cca 691 His Tyr Asn Leu Val Ser Arg Lys Asp Tyr Glu Glu Asn Val Gln Pro 185 190 195 etc. gcc gag aag cat ggc gtt gca gtc ttc cct tat ttc gcg ctt gcc 739 Leu Wing Glu Lys His Gly Val Wing Val Phe Pro Tyr Phe Wing Leu Wing 200 205 210 gcg gtt ctt ttg acc gga aag tac acc tcc aag gag gat att tcg ggt 787 Wing Gly Leu Leu Thr Gly Lys Tyr Thr Ser Lys Glu Asp He Ser Gly 215 220 225 aaa gcg cgt gcg ggg cag ttg gat cgt tac gcc age gat gag gcg ttt 835 Lys Ala Arg Ala Gly Gln Leu Asp Arg Tyr Ala Ser Asp Glu Ala Phe 230 235 240 245 gcc gtg gtg here gag ttg cgt gct gtt gcc gat gag ttg ggt gtt gcg 883 Wing Val Val Thr Glu Leu Arg Ala Val Wing Asp Glu Leu Gly Val Wing 250 255 260 cca acg act gtg gcg ctt gcg tgg ttg gtt gcg cat ggt gtg acc gca 931 Pro Thr Thr Val Wing Leu Wing Trp Leu Val Wing His Gly Val Thr Wing 265 270 275 ccg att gcg tcc gtg tcc aag gta gag cag ttg aag gat ttg atg gct 979 Pro He Wing Ser Val Ser Lys Val Glu Gln Leu Lys Asp Leu Met Wing 280 285 290 gtg aag gat gtg gag ctg age gct gag cag ctt gca cgt ttg gat aag 1027 Val Lys Asp Val Glu Leu Ser Ala Glu Gln Leu Ala Arg Leu Asp Lys 295 300 305 gtt tcg gag cct tcc gct taagctct: cc t: caaaagtaa gtg 1068 Val Ser Glu Pro Phe Wing 310 315 < 210 > 672 < 211 > 315 < 212 > PRT < 213 > Cc > rynebact: epum glutamicum < 400 > 672 Met Glu His Gly Val Thr Val He Lys Gly Thr Glu Phe Asp Val Phe 1 5 10 15 Pro Leu Asn Leu Gly Gly Asn Thr Phe Gly Trp Thr Ser Asn Arg Glu 20 25 30 Gln Thr Phe Wing Val Leu Asp Wing Phe Val Wing Wing Gly Gly Asn Phe 35 40 45 Val Asp Thr Wing Asp Ser Tyr Ser Wing Trp Val Glu Gly Asn Glu Gly 50 55 60 Gly Glu Ser Glu Arg Glu Leu Gly Wing Trp He Lys Glu Arg Gly Wing 65 70 75 80 sp Lys Leu He He Wing Thr Lys Ser Gly Wing Leu Glu Pro Val Wing 85 90 95 Gly Arg Ser Arg Glu Wing Thr Phe Lys Wing Val Glu Gly Ser Leu Glu 100 105 110 Arg Leu Gly Val Glu Ser He Asp He Phe Tyr Tyr His Tyr Asp Asp 115 120 125 Glu Ala Val Ser He Asp Glu Gln Val Ala Ala Asn Asp Leu He 130 135 140 Wing Gln Gly Lys He Lys His Leu Wing Leu Ser Asn Tyr Ser Wing Glu 145 150 155 160 Arg Leu Wing Glu Phe Phe Glu Lys Ser Val Gly Thr Pro Wing Gln Pro 165 170 175 Val Ala Leu Gln Pro His Tyr Asn Leu Val Ser Arg Lys Asp Tyr Glu 180 185 190 Glu Asn Val Gln Pro Leu Wing Glu Lys His Gly Val Wing Val Phe Pro 195 200 205 Tyr Phe Ala Leu Wing Wing Gly Leu Leu Thr Gly Lys Tyr Thr Ser Lys 210 215 220 Glu Asp He Ser Gly Lys Ala Arg Ala Gly Gln Leu Asp Arg Tyr Ala 225 230 235 240 Ser Asp Glu Ala Phe Ala Val Val Thr Glu Leu Arg Ala Val Ala Asp 245 250 255 Glu Leu Gly Val Ala Pro Thr Thr Val Ala Leu Ala Trp Leu Val Ala 260 265 270 His Gly Val Thr Ala Pro He Ala Ser Val Ser Lys Val Glu Gln Leu 275 280 285 Lys Asp Leu Met Wing Val Lys Asp Val Glu Leu Ser Ala Glu Gln Leu 290 295 300 Wing Arg Leu Asp Lys Val Ser Glu Pro Phe Wing 305 310 315 < 210 > 673 < 211 > 1758 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (1735) < 223 > RXN01164 < 400 > 673 gccgatcgtg attgatgaag acgagatcca agectggact tctgatctca aacctgaaga 60 tttcaccaaa ggtaaagatg aatccgacgg tgagaaataa gtg here ctg ttt gtt 115 Val Thr Leu Phe Val 1 5 cgg etc gcc ctt gct gct gg ggg ggg ctt ttt gtc gtc ttt gtcc aat 163 Arg Leu Ala Leu Ala Ala Val Gly Gly Leu Phe Val Phe Ala Ser Asn 10 15 20 gaa ccg ate ggc tgg ttt gtc gcg gga att gtt ggc act gca tta ttt 211 Glu Pro He Gly Trp Phe Val Wing Gly He Val Gly Thr Ala Leu Phe 25 30 35 ttt ate tcc ctt gcg ccg tgg gat ctg gga gtt ccc caa aag cgg cgg 259 Phe He Ser Leu Ala Pro Trp Asp Leu Gly Val Pro Gln Lys Arg Arg 40 45 50 aag aag aga gag cca gtc cca ttt ttg caa cag atg tcc acg ggc cca 307 Lys Lys Asn Glu Pro Val Pro Phe Leu Gln Gln Met Ser Thr Gly Pro 55 60 65 act gtt gta cag ggc atg ctt tta ggt ttt gtc cat ggc ctg gtg here 355"4 > .

Thr Val Val Gln Gly Met Leu Leu Gly Phe Val His Gly Leu Val Thr 70 75 80 85 tat ttg cag ctg ttg ccg tgg ate ggt gag ttt gtt ggc tca ctg cct 403 Tyr Leu Gln Leu Pro Trp He Gly Glu Phe Val Gly Be Leu Pro 90 95 100 tat gtc gcg ttg ttg gtc gtc gag gcg ctt tat tcc att gct ctt ggt 451 Tyr Val Wing Leu Ser Val Val Glu Wing Leu Tyr Ser He Wing Leu Gly 105 110 115 - gct ttc ggc gtg etc att gcg cgt tgg agg gac tgg aag gtt etc ctg 499 • Wing Phe Gly Val Leu He Wing Arg Trp Arg Asp Trp Lys Val Leu Leu 120 125 130 ttt ccg gcg atg tat gtg gct gg gag tat cta aga age tcg tgg cca 547 Phe Pro Wing Met Tyr Val Wing Val Glu Tyr Leu Arg Ser Ser Trp Pro 135 140 145 ttt gat gga ttc gcg tgg gtt cgc ctg gca tgg ggt caa att aac ggt 595 phe asp gly phe wing trp val arg leu wing trp gly gln hen asn gly 150 155 160 165 ccg ttg gct aat etc gca gcg ctt ggt ggg gta gcg ttt gtc act ttt 643 Pro Leu Ala Asn Leu Ala Ala Leu Gly Gly Val Ala Phe Val Thr Phe 170 175 180 1Q tcc acg gtg ctg gct gcc gtg ggt gtg gcc atg gtg att att tcc aag 691 Ser Thr Val Leu Ala Wing Val Gly Val Wing Met Val He He Ser Lys 185 190 195 aag cga gt gc gc ate ate gcg agt gtg att gct ate ggc 739 Lys Arg Leu Ala Gly Ala He He Thr Ala Ser Val He Ala He Gly 200 205 210 gcg gtg tca tc ctg tac gtt gac cgc aat ggc acg age gat gaa age 787 Wing Val Ser Ser Leu Tyr Val Asp Arg Asn Gly Thr Ser Asp Glu Ser 215 220 225 ate gaa gta gcc gca att cag ggc aat g tg cct cgg atg gga ttg gac 835 He Glu Val Ala Ala He Gln Gly Asn Val Pro Arg Met Gly Leu Asp 230 235 240 245 1 ttc aat gca cag cgc cgc gcg gtg ctg gcg aat falls gca cgg gaa acc 883 Phe Asn Ala Gln Arg Arg Ala Val Leu Ala Asn His Ala Arg Glu Thr 250 255 260 etc aag ctg gat gaa caa gtg gat ttg gtg ate tgg ccg gag aat tcc 931 Leu Lys Leu Asp Glu Gln Val Asp Leu Val He Trp Pro Glu Asn Ser 265 270 275 tca gac gtc aac cca ttt tcc gat gca caa gca aga gcc att ate gat 979 Ser Asp Val Asn Pro Phe Ser Asp Ala Gln Ala Arg Ala He He Asp 280 285 290 • gga gca gtg gaa cat gtt cag gca cct att ttg gtg ggc acg ate acc 1027 Gly Wing Val Glu His Val Gln Wing Pro He Leu Val Gly Thr He Thr 295 300 305 20 gtc gat gag gtt ggt cca cgc aac acc atg cag gta ttt gat cct gtt 1075 Val Asp Glu Val Gly Pro Arg Asn Thr Met Gln Val Phe Asp Pro Val 310 315 320 325 gaa ggt gcc gcg gag tac falls aat aag tag ttc cag ccg ttt ggt 1123 Glu Gly Ala Ala Glu Tyr His Asn Lys Lys Phe Leu Gln Pro Phe Gly 330 335 340 gaa tac atg ccg ttt cgc gaa ttc ctg aga att ttc tcg ccc tac gtt 1171 Glu Tyr Met Pro Phe Arg Glu Phe Leu Arg He Phe Ser Pro Tyr Val 345 350 355 gat tcc gct gga aac ttc cag ccc ggt gat ggc acc ggc gta gtg gag 1219 Asp Ser Wing Gly Asn Phe Gln Pro Gly Asp Gly Thr Gly Val Val Glu 360 365 370 25 atg aat gct gcg aac tta ggc cgc gct gtg here gtg ggc gtg atg acg 1267 ^ - * »- * ^ > - »- Met Asn Wing Wing Asn Leu Gly Arg Wing Val Thr Val Gly Val Met Thr 375 380 385 tgt tac gag gtc ate ttc gac cgt gct ggc cgc gac gcc ate gcc aat 1315 Cys Tyr Glu Val He Phe Asp Arg Wing Gly Arg Asp Wing He Wing Asn 390 395 400 405 ggg gct gaa ttt ttg ac ac ccc ac aac aac gcc acc ttc gga ttc 1363 Gly Ala Glu Phe Leu Thr Thr Pro Thr Asn Asn Wing Thr Phe Gly Phe 410 415 420 acg gac atg acg tat cag caa tta gca atg age agg atg cgt gcc ate 1411 Thr Asp Met Thr Tyr Gln Gln Leu Ala Met Ser Arg Met Arg Wing He 425 430 435 gaa ttt gat agg gcg gtg gtt gtt gca gct here tcg ggt gtt tcg gct 1459 Glu Phe Asp Arg Wing Val Val Val Wing Wing Thr Ser Gly Val Ser Wing 440 445 450 ate gtc aac cct gat gga age att tcc caa aac acc cga att ttt gag 1507 He Val Asn Pro Asp Gly Be He Be Gln Asn Thr Arg He Phe Glu 455 460 465 gcc gcc acc ttg acg gaa tcc att cca etc aag gac act gtc acc ate 1555 Ala Ala Thr Leu Thr Glu Ser He Pro Leu Lys Asp Thr Val Thr He 470 475 480 485 gca gcg cgg gtt gt t tat gtt gaa tta ctg ttg gtt ate att ggt 1603 Wing Wing Arg Val Gly Phe Tyr Val Glu Leu Leu Leu Val He He Gly 490 495 500 gta tta gct gga cta ttc gcc att cga atg aat age cgt tca aag tet 1651 Val Leu Ala Gly Leu Phe Ala He Arg Met Asn Ser Arg Ser Lys Ser 505 510 515 gcg aaa ggt tcc gct cgg ccc gca caa gtt cgg gtt aag aag gtg cct 1699 Wing Lys Gly Wing Wing Arg Pro Wing Gln Val Arg Val Lys Lys Val Pro 520 525 gcg aaa aag gca gca act aat cgt cga aaa gta aaa taaaaacgtc 1745 Ala Lys Lys Ala Ala Thr Asn Arg Arg Lys Val Lys 535 540 545 ccgaagggac gag 1758 < 210 > 674 < 211 > 545 < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 674 Val Thr Leu Phe Val Arg Leu Ala Leu Ala Wing Val Gly Gly Leu Phe 1 5 10 15 Val Phe Wing Being Asn Glu Pro He Gly Trp Phe Val Wing Gly He Val 20 25 30 Gly Thr Wing Leu Phe Phe He Being Leu Wing Pro Trp Asp Leu Gly Val 35 40 45 Pro Gln Lys Arg Arg Lys Lys Asn Glu Pro Val Pro Phe Leu Gln Gln 50 55 60 Met Ser Thr Gly Pro Thr Val Val Gln Gly Met Leu Leu Gly Phe Val 65 70 75 80 His Gly Leu Val Thr Tyr Leu Gln Leu Leu Pro Trp He Gly Glu Phe 85 90 95 Val Gly Ser Leu Pro Tyr Val Ala Leu Ser Val Val Glu Ala Leu Tyr 100 105 110 Ser He Ala Leu Gly Ala Phe Gly Val Leu He Ala Arg Trp Arg Asp 115 120 125 Trp Lys Val Leu Leu Phe Pro Wing Met Tyr Val Val Wing Val Glu Tyr Leu m__¡_ «S« í í a .., í í - 130 135 140 Arg Ser Ser Trp Pro Phe Asp Gly Phe Wing Trp Val Arg Leu Wing Trp 145 150 155 160 Gly Gln He Asn Gly Pro Leu Wing Asn Leu Wing Wing Leu Gly Gly Val 165 170 175 Wing Phe Val Thr Phe Ser Thr Val Leu Wing Wing Val Gly Val Wing Met 180 185 190 Val He He Ser Lys Lys Arg Leu Wing Gly Ala He He Thr Ala Ser 195 200 205 Val He Ala He Gly Ala Val Ser Ser Leu Tyr Val Asp Arg Asn Gly 210 215 220 Thr Ser Asp Glu Ser He Glu Val Ala Ala He Gln Gly Asn Val Pro 225 230 235 240 Arg Met Gly Leu Asp Phe Asn Wing Gln Arg Arg Wing Val Leu Wing Asn 245 250 255 His Wing Arg Glu Thr Leu Lys Leu Asp Glu Gln Val Asp Leu Val He 260 265 270 Trp Pro Glu Asn Ser As Asp Val Asn Pro Phe Ser Asp Ala Gln Ala 275 280 285 Arg Ala He He Asp Gly Ala Val Glu His Val Gln Ala Pro He Leu 10 290 295 300 Val Gly Thr He Thr Val Asp Glu Val Gly Pro Arg Asn Thr Met Gln 305 310 315 320 Val Phe Asp Pro Val Glu Gly Ala Ala Glu Tyr His Asn Lys Lys Phe 325 • 330 335 Leu Gln Pro Phe Gly Glu Tyr Met Pro Phe Arg Glu Phe Leu Arg He 340 345 350 Phe Ser Pro Tyr Val Asp Ser Ala Gly Asn Phe Gln Pro Gly Asp Gly 355 360 365 Thr Gly Val Val Glu Met Asn Wing Wing Asn Leu Gly Arg Wing Val Thr 370 375 380 Val Gly Val Met Thr Cys Tyr Glu Val He Phe Asp Arg Wing Gly Arg 15 385 390 395 400 Asp Wing He Wing Asn Gly Wing Glu Phe Leu Thr Thr Pro Thr Asn Asn 405 410 415 Wing Thr Phe Gly Phe Thr Asp Met Thr Tyr Gln Gln Leu Wing Met Ser 420 425 430 Arg Met Arg Wing He Glu Phe Asp Arg Wing Val Val Val Ala Ala Thr 435 440 445 Ser Gly Val Ser Wing He Val Asn Pro Asp Gly Ser He Gln Asn 450 455 460 • Thr Arg He Phe Glu Ala Wing Thr Leu Thr Glu Ser He Pro Leu Lys 465 470 475 480 Asp Thr Val Thr He Ala Wing Arg Val Gly Phe Tyr Val Glu Leu Leu 20 485 490 495 Leu Val He He Gly Val Leu Wing Gly Leu Phe Wing He Arg Met Asn 500 505 510 Ser Arg Ser Lys Ser Wing Lys Gly Ser Wing Arg Pro Wing Gln Val Arg 515 520 525 Val Lys Lys Val Pro Wing Lys Lys Ala Ala Thr Asn Arg Arg Lys Val 530 535 540 Lys 545 < 210 > 675 < 211 > 933 25 < 212 > DNA < 213 > Corynebacterium glutamicum < 220 > < 221 > CDS < 222 > (101) .. (910) < 223 > RXN01168 < 400 > 675 ccgcacaagt -tegggttaag aaggtgcctg cgaaaaaggc ageaactaat, cgtcigaaaag 60 taaaataaaa; acgtcccg; aa gggacgagga ggacaacacc atg age agt gag gca 115 Met Ser Ser Glu Ala 1 5 gta gat gct acg acg ctg gtg att att cca acg tac aac gag ctg gaa 163 Val Asp Wing Thr Thr Leu Val He He Pro Thr Tyr Asn Glu Leu Glu 10 15 20 aac ctt cca ccc gcg gcg gcg gcg gcgc gc acc acccct gac gtt 211 Asn Leu Pro Leu He Val Asp Arg Val Arg Thr Ala Thr Pro Asp Val 25 30 35 fall gta etc ate gtg gac gac aac age cca gac ggc acc ggc gag cgc 259 His Val Leu He Val Asp Asp Asn Ser Pro Asp Gly Thr Gly Glu Arg 40 45 50 gca gac aag ctt gct gct gac gac gac falls att ttt gtc etc falls cgc 307 Wing Asp Lys Leu Wing Wing Asp Asp Asp His He Phe Val Leu His Arg 55 60 65 gaa ggc aaa ggc ggc ctg tgc gca gag tac atg gct ggc ttc cag tgg 355 Glu Gly Lys Gly Gly Leu Cys Wing Glu Tyr Met Wing Gly Phe Gln Trp 70 75 80 85 ggc ctg gag cgc gac tac cag gtc ctg tgc gaa atg gac gcc gac ggc 403 Gly Leu Glu Arg Asp Tyr Gln Val Leu Cys Glu Met Asp Wing Asp Gly 90 95 100 tcc falls gca cca gaa cag ctg drops ctg ctg etc gct gag ate acc aat 451 Ser His Wing Pro Glu Gln Leu His Leu Leu Leu Wing Glu He Thr Asn 105 110 115 ggc gct gac ctg gtc ate ggc tcg cgc tac gtg cca ggc ggc cgc gta 499 Gly Wing Asp Leu Val He Gly Ser Arg Tyr Val Pro Gly Gly Arg Val 120 125 130 gtc aac tgg ccc aag aac cgt tgg etc ttg tcc aag ggc ggc aac gtc 547 Val Asn Trp Pro Lys Asn Arg Trp Leu Leu Ser Lys Gly Gly Asn Val 135 140 145 tac ate age gtc gcg etc ggc gcc ggc ttg acc gat gg acc ggg ggg 595 Tyr He Ser Val Ala Leu Gly Ala Gly Leu Thr Asp Met Thr Ala Gly 150 155 160 165 tac cgc gct ttt cga cgt gaa gtg cta gaa gca ctg ccg ctt gat gag 643 Tyr Arg Wing Phe Arg Arg Glu Val Leu Glu Wing Leu Pro Leu Asp Glu 170 175 180 etc tcc aac gct ggg tac att ttc caa gtt gag att gcc tac cgt gca 691 Leu Ser Asn Wing Gly Tyr He Phe Gln Val Glu He Wing Tyr Arg Wing 185 190 195 gtt gaa gcc gga ttc gat gtt cgt gaa gtt ccc ate act ttc acc gag 739 Val Glu Ala Gly Phe Asp Val Arg Glu Val Pro He Thr Phe Thr Glu 200 205 210 cgt gag ate ggc gaa tcc aag ctg gac ggc age ttt gtc aag gat tcc 787 Arg Glu He Gly Glu Ser Lys Leu Asp Gly Ser Phe Val Lys Asp Ser 215 2 20 225 ctg etc gag gta acc aag tgg ggc etc aag drops cgc ggt ggc cag gcc 835 Leu Leu Glu Val Thr Lys Trp Gly Leu Lys His Arg Gly Gly Gln Ala 230 235 240 245 aag gaa ctg tcc aag gaa atg gtc ggc ctg ctg aac tat gag tgg aag 883 Lys Glu Leu Ser Lys Glu Met Val Gly Leu Leu Asn Tyr Glu Trp Lys 250 255 260 falls ttc aaa aag cgc aac acc tgg etc taaactgctt gccggttagt 930 His Phe Lys Lys Arg Asn Thr Trp Leu 265 270 gaa 933 < 210 > 676 < 211 > 270 • < 212 > PRT < 213 > Corynebacterium glutamicum < 400 > 676 Met Ser Ser Glu Wing Val Asp Wing Thr Thr Leu Val He He Pro Thr 1 5 10 15 Tyr Asn Glu Leu Glu Asn Leu Pro Leu He Val Asp Arg Val Arg Thr 20 25 30 Wing Thr Pro Asp Val His Val Leu He Val Asp Asp Asn As Pro Asp 35 40 45 10 Gly Thr Gly Glu Arg Wing Asp Lys Leu Wing Wing Asp Asp Asp His He 50 55 60 Phe Val Leu His Arg Glu Gly Lys Gly Gly Leu Cys Glu Wing Tyr Met 65 70 75 80 Wing Gly Phe Gln Trp Gly Leu Glu Arg Asp Tyr Gln Val Leu Cys Glu • 85 90 95 Met Asp Wing Asp Gly Ser His Wing Pro Glu Gln Leu His Leu Leu Leu 100 105 110 Wing Glu He Thr Asn Gly Wing Asp Leu Val He Gly Ser Arg Tyr Val 115 120 125 Pro Gly Gly Arg Val Val Asn Trp Pro Lys Asn Arg Trp Leu Leu Ser 130 135 140 15 Lys Gly Gly Asn Val Tyr He Ser Val Wing Leu Gly Wing Gly Leu Thr 145 150 155 160 Asp Met Thr Wing Gly Tyr Arg Wing Phe Arg Arg Glu Val Leu Glu Wing 165 170 175 Leu Pro Leu Asp Glu Leu Ser Asn Wing Gly Tyr He Phe Gln Val Glu 180 185 190 He Wing Tyr Arg Wing Val Glu Wing Gly Phe Asp Val Arg Glu Val Pro 195 200 205 He Thr Phe Thr Glu Arg Glu He Gly Glu Ser Lys Leu Asp Gly Ser 210 215 220 • Phe Val Lys Asp Ser Leu Leu Glu Val Thr Lys Trp Gly Leu Lys His 225 230 235 240 20 Arg Gly Gly Gln Ala Lys Glu Leu Ser Lys Glu Met Val Gly Leu Leu 245 250 255 Asn Tyr Glu Trp Lys His Phe Lys Lys Arg Asn Thr Trp Leu 260 265 270 < 210 > 677 < 211 > 18 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Description of the Artificial Sequence: First 25 • m "*" - '"¿. < 400 > 677 ggaaacagta tgaccatg 18 < 210 > 678 < 211 > 17 < 212 > DNA < 213 > Artificial Sequence < 220 > • < 223 > Description of the Artificial Sequence: Primer < 400 > 678 gtaaaacgac ggccagt 17 10 fifteen • twenty 25

Claims (1)

1. CLAIMS A nucleic acid molecule isolated from Corynebacterium gluta icum that encodes a MCT protein, or a portion thereof, provided that the nucleic acid molecule does not consist of any of the genes designated with the letter F presented in Table 1 The isolated nucleic acid molecule of claim 1, wherein said nucleic acid molecule encodes a MCT protein involved in the production of a fine chemical. An isolated Corynebacterium glutamicum nucleic acid molecule selected from the group consisting of the sequences presented as SEQ ID NOs of the odd number of the Sequence List, or a portion thereof, provided that the nucleic acid molecule does not consist of none of the genes designated with the letter F presented in Table 1. An isolated nucleic acid molecule encoding a polypeptide sequence that is selected from the group consisting of the sequences presented as SEQ ID NOs of even number from the List of Sequences, provided that the nucleic acid molecule does not consist of any of the genes designated with the letter F presented in Table 1. 5. An isolated nucleic acid molecule encodes an allelic variant that occurs naturally from a polypeptide selected from the group of amino acid sequences consisting of the sequences 5 presented as SEQ ID NOs of even numeral of the Sequence List, provided that the nucleic acid molecule does not consist of any of the rens designated with the letter F presented in Table 1. 6. A nucleic acid molecule isolate comprising a nucleotide sequence having a homology of at least 50% with a nucleotide sequence selected from the group consisting of the sequences presented as SEQ ID NOs of odd number from the Sequence List, or ur. a pcrciór. of it, to 15 condition that the nucleic acid molecule does not consist of any of the genes designated with the letter F presented in Table 1., ájjk 1. An isolated nucleic acid molecule comprising a fragment of at least 15 nucleotides of an acid The nucleic acid comprising a nucleotide sequence selected from the group consisting of the sequences presented as SEQ ID NOs of the odd number of the Sequence List, as appropriate. that the nucleic acid molecule does not consist of genes insur.o 25 designated with the letter F presented er. Table 1 . An isolated nucleic acid molecule that hybridizes to the nucleic acid molecule of any of claims 1-7 under stringent conditions. 9. An isolated nucleic acid molecule comprising the nucleic acid molecule of any of claims 1-8 or a portion thereof, and a nucleotide sequence encoding a heterologous polypeptide. 10. A vector comprising the nucleic acid molecule of any of claims 1-9. 11. The vector according to claim 10, which is an expression vector. 12. A host cell transfected with the expression vector of claim 11. 13. The host cell according to claim 12, wherein said cell is ur. microorganism. 14. The host cell according to claim 1. 13, wherein said cell belongs to the genus Corynebacterium or Brevibacteriun. 15. The host cell in accordance with the claim 12, wherein the expression of said nucleic acid molecule results in the modulation of the production of a fine chemical from said cell. 16. The host cell according to claim 1. 15, wherein said fine chemical is selected within .TO '..-!. * of the group consisting of: organic acids, proteinogénicos and non-protogénico amino acids, purine and pyrimidine bases, nucleosides, nucleotides, lipids, saturated and ipsaturated fatty acids, diols, carbohydrates, aromatics, vitamins, cofactors, polyketides, and enzymes. 7. A method for the production of a polypeptide, which comprises culturing the host cell of claim 12 in an appropriate culture medium to thereby produce the polypeptide. 8. A polypeptide isolated from MCT of Corynebacterium glutamicum, or a portion thereof. S.E1 polypeptide according to claim 18, wherein said polypeptide is involved in the production of a fine chemical. 1'. An isolated polypeptide comprising an amino acid sequence selected from the group consisting of the sequences presented as SEQ ID NOs of even number in the Sequence List, provided that the amino acid sequence is not encoded by any of the genes designated with the letter F presented in Table 1. 1. An isolated polypeptide comprising a naturally occurring allelic variant of a polypeptide comprising a selected amino acid sequence. within the group consisting of the sequences presented in SEQ ID NOs of even number of the Sequence List, or a portion thereof, provided that the amino acid sequence is not encoded by any of the genes designated with the letter F presented in Table 1. 22. The isolated polypeptide according to any of claims 18-21, further comprising heterologous amino acid sequences. 23. An isolated polypeptide that is encoded by a nucleic acid molecule comprising a nucleotide sequence having a homology of at least 50% with a nucleic acid selected from the group consisting of the sequences presented as SEQ ID NOs of odd number of the Sequence List, provided that the nucleic acid molecule does not consist , of any of the nucleic acid molecules designated by the letter F presented in Table 1. 24. An isolated polypeptide comprising an amino acid sequence having a homology of at least 50% with a selected amino acid sequence within the group consisting of the sequences presented as SEQ ID NOs of even number of the Sequence List, provided that the amino acid sequence is not encoded by any of the genes i S l.i designated with the letter F presented in Table 1. 25. A method for producing a fine chemical, comprising the cultivation of a cell containing a vector of claim 12 so as to produce the 5 fine chemical. 26. The method according to claim 25, wherein said method comprises the step of recovering the fine chemical from said culture. 27. The method according to claim 25, er. Wherein said method comprises aoemás the step of transfecting said cell with the vector of claim 11 to result in a cell containing said vector. 28. The method according to claim 25, wherein said cell belongs to the genus Corynebacteriuir. or Brevibacterium. 29. The method according to claim 25, wherein said cells are selected from the group consisting of: Corynebacterium glutamicum, Corynebacterium herculis, Coryneracterium, Lilium, Corynebacterium acetoacidophilurr., Corynebacteriur. acetoglutamicum, Corynebactep_-a acetophilum, Corynebacterium ammoniagenes, Corynebacteriur :. fujiokense, Corynebacterium nitrilophilus, 25 Brevibacterium ammoniagenes, Breviracterium butanicum, a Brevibacterium divaricatu, Brevibacterium flavu, Brevibacterium healii, Brevibacteriur. ketogluta icum, Brevibacterium ketosoreductum, Brevibacterium lactofermentum, Brevibacterium linens, Brevibacterium 5 paraffinolyticum, and the strains presented in Table 3. 30. The method according to claim 25, wherein the expression of the nucleic acid molecule from said vector results in modulation of the 10 production of said fine chemical. 31. The method according to claim 25, wherein said fine chemical is selected from the group consisting of: organic acids, proteinogenic and non-proteinogenic amino acids, purine bases and 15 pyrimidine, nucleosides, nucleotides, lipids, saturated and unsaturated fatty acids, diols, carbohydrates, aromatics, vitamins, cofactors, -ÉB polyketides, and enzymes. 32. The method according to claim 25, wherein said fine chemical is an amino acid. 33. The method according to claim 32, wherein said amino acid is selected from the group consisting of: lysine, glutamate, glutamine, alanine, aspartate, glycine, serine, tremin, methionine, 25 cysteine, valine, leucine, isoleucine, arginine, . ? .1i. Proline, histidine, tyrosine, femlalanine, and tryptophan. A method for the production of a fine chemical, comprising the cultivation of a cell whose genomic DNA has been altered by the inclusion of a nucleic acid molecule of any of claims 1-9. A method for diagnosing the presence or activity of Corynebacterium diphtheriae in a subject, comprising detecting the presence of one or more of SEQ ID NOs 1 to 676 of the Sequence List in the subject, provided that the sequences are not encoded by any of the sequences designated by the letter F presented in the Table. 1, diagnosing in this way the presence or activity of Corynebacterium diphtheriae in the subject. A host cell comprising a nucleic acid molecule selected from the group consisting of the nucleic acid molecules presented as SEQ ID Odd number NOs of the Sequence List, where the nucleic acid molecule is disorganized. A host cell comprising a nucleic acid molecule selected from the group consisting of the nucleic acid molecules presented as SEQ ID NOs of the odd number of the Sequence List, wherein the nucleic acid molecule comprises one or more modifications of acid nucleic of the sequences presented as SEQ ID NOs of odd number from the Sequence List. A host cell comprising a nucleic acid molecule selected from the group consisting of the nucleic acid molecules presented as SEQ ID Odd number NOs of the Sequence List, wherein the regulatory region of the nucleic acid molecule is modified in comparison to the wild-type modulator region of the molecule.