KR100834989B1 - Corynebacterium Glutamicum Genes Encoding Proteins Involved in Membrane Synthesis and Membrane Transport - Google Patents

Abstract

The present invention describes an isolated nucleic acid molecule named MCT nucleic acid molecule, encoding a novel MCT protein from Corynebacterium glutamicum . The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCT nucleic acid molecules and host cells into which the expression vectors have been introduced. The invention also provides for the production of the desired compound from the organism based on the genetic engineering of the MCT gene in isolated MCT protein, MCT protein mutation, fusion protein, antigenic peptide, and Corynebacterium glutamicum. Provide a method.

Description

Corynebacterium Glutamicum Genes Encoding Proteins Involved in Membrane Synthesis and Membrane Transport

Related Applications

This application claims priority to US Provisional Patent Application No. 60/141031 (filed June 25, 1999), which was filed prior to this application date. The present application is also filed in German Patent Application No. 1931454.3 (filed Jul. 8, 1999), German Patent Application No. 1931478.0 (filed Jul. 8, 1999), and German Patent Application No. 19931563.9 (July 8, 1999). ), German Patent Application No. 99322122.1 (filed Jul. 9, 1999), German Patent Application No. 19323124.8 (filed Jul. 9, 1999), German Patent Application No. 199322125.6 (filed Jul. 9, 1999), German Patent Application No. 199322128.0 (filed Jul. 9, 1999), German Patent Application No. 19932180.9 (filed July 9, 1999), German Patent Application No. 19932182.5 (filed July 9, 1999), German patent Application No. 1932190.6 (filed Jul. 9, 1999), German Patent Application No. 19932191.4 (filed July 9, 1999), German Patent Application No. 19932209.0 (filed July 9, 1999), German Patent Application No. 19932212.0 (filed Jul. 9, 1999), German patent application No. 1932227.9 (filed July 9, 1999), German patent application 19932228.7 (July 9, 1999) Application), German Patent Application No. 1932229.5 (filed July 9, 1999), German Patent Application No. 1932230.9 (filed July 9, 1999), German Patent Application No. 1932 2927.3 (filed July 14, 1999) German Patent Application No. 1933005.0 (filed July 14, 1999), German Patent Application No. 1933006.9 (filed July 14, 1999), German Patent Application No. 19940764.9 (filed August 27, 1999), Germany Patent Application No. 19940765.7 (filed August 27, 1999), German Patent Application No. 19940766.5 (filed August 27, 1999), German Patent Application No. 19940830.0 (filed August 27, 1999), German Patent Application 19940831.9 filed August 27, 1999; German Patent Application No. 19940832.7 (filed August 27, 1999); German Patent Application No. 19940833.5 (filed August 27, 1999); German Patent Application No. 19941378.9 (August 31, 1999), German Patent Application No. 19941379.7 (August 31, 1999), German Patent Application No. 19941395.9 (August 1999) Application No. 31), German Patent Application No. 19942077.7 (filed September 3, 1999), German Patent Application No. 19942078.5 (filed September 3, 1999), German Patent Application No. 19942079.3 (September 3, 1999) Application), and German patent application No. 19942088.2 (filed Sep. 3, 1999) as priority. The entire contents of all such applications are expressly incorporated herein by reference.

Some products and by-products of naturally occurring metabolic processes in cells are used in a variety of industries, including the food, feed, cosmetic and pharmaceutical industries. These molecules, collectively referred to as "fine chemicals", include organic acids, proteomic and nonproteinaceous amino acids, nucleotides and nucleosides, lipids and fatty acids, diols, carbohydrates, aromatic compounds, vitamins and cofactors, and enzymes. Their production is most conveniently done through large-scale cultivation of bacteria developed to produce and secrete large quantities of specific molecules of interest. A particularly useful organism for this purpose is Corynebacterium glutamicum, a gram positive nonpathogenic bacterium. Through strain selection, a number of mutant strains have been developed that produce a series of desirable compounds. However, the selection of improved strains for the production of certain molecules is a time consuming and difficult process.

Summary of the Invention

The present invention provides novel bacterial nucleic acid molecules with various uses. These include identification of microorganisms that can be used for the production of fine chemicals; Regulating the production of fine chemicals in Corynebacterium glutamicum or related bacteria; Typing or identification of Corynebacterium glutamicum or related bacteria; It is used as a reference point for mapping the genome of Corynebacterium glutamicum and as a marker for transformation. These novel nucleic acid molecules encode proteins, referred to herein as membrane constituent and membrane transport (MCT) proteins.

Corynebacterium glutamicum is a Gram-positive aerobic bacterium commonly used industrially for the mass production of various fine chemicals, the decomposition of hydrocarbons (eg, mineral oil spills) and the oxidation of terpenoids. Thus, the MCT nucleic acid molecules of the present invention can be used to identify microorganisms that can be used to produce fine chemicals, for example, by fermentation processes. Controlling the expression of MCT nucleic acids of the invention or sequence variations of the MCT nucleic acid molecules of the invention can be used to control the production of one or more fine chemicals from microorganisms (eg, Corynebacterium or Brevibacterium species To improve the production or production of one or more fine chemicals from.

The MCT nucleic acids of the present invention can be used to identify organisms that may be Corynebacterium glutamicum or its analogues, or to identify the presence of Corynebacterium glutamicum or its analogs in a mixed microbial population. It may be. The present invention provides for the presence of such organisms by probing extracted genomic DNA in culture of the same or mixed microbial population using probes spanning the Corynebacterium glutamicum gene region unique to Corynebacterium glutamicum under stringent conditions. Nucleic acid sequences of many Corynebacterium glutamicum genes can be identified. Although Corynebacterium glutamicum itself is not pathogenic, it is associated with species pathogenic to humans, such as Corynebacterium diphtheria (pathogen of diphtheria), and the detection of such organisms is of clinical importance.

The MCT nucleic acid molecule of the present invention can also be used as a reference point for mapping the genome of Corynebacterium glutamicum or the genome of related organisms. Similarly, these molecules, variants or portions thereof, can be used as markers for genetically engineered Corynebacterium or Brevibacterium species.

MCT proteins encoded by the novel nucleic acid molecules of the present invention perform functions related to metabolism (eg, biosynthesis or degradation) of a compound required for membrane biosynthesis, for example, or incorporation of one or more compounds into or from a cell. Transmembrane transport can be assisted. Cloning vectors for use in Corynebacterium glutamicum, such as the cloning vectors disclosed in US Pat. No. 4,649,119 (Sinskey et al.), And Corynebacterium glutamicum and related Brevibacterium species (eg, lactose). Fermentum) (Yoshihama et al, J. Bacteriol. 162: 591-597 (1985); Katsumata et al., J. Bacteriol. 159: 306-311 (1984); and Santamaria et al., J Gen. Microbiol. 130: 22372246 (1984)), the nucleic acid molecules of the present invention can be used for genetic engineering of such organisms such that they are more efficient producers of one or more fine chemicals. Genetic engineering of the present invention can directly or indirectly affect the production or production efficiency of fine chemicals.

There are several mechanisms that can directly affect the yield, production and / or production efficiency of fine chemicals from the Corynebacterium glutamicum strain comprising the modified protein by the modification of the MCT protein of the present invention. . Such MCT proteins, which are involved in the release of fine chemical molecules from cells, can be increased in number or activity so that more of these compounds are secreted into the extracellular medium from which they are more readily recovered. Similarly, MCT proteins involved in the influx of nutrients (eg, phosphates, sulfates, nitrogen compounds, etc.) required for the biosynthesis of one or more fine chemicals have increased intracellular concentrations of these precursors, cofactors or intermediates. If possible, its number or activity may be increased. In addition, the fatty acids and lipids themselves are preferred fine chemicals, and by optimizing the activity of or increasing the number of one or more MCT proteins of the present invention involved in the biosynthesis of such compounds, or one involved in the degradation of these compounds. By impairing the activity of the above MCT protein, the yield, production and / or production efficiency of fatty acid and lipid molecules from Corynebacterium glutamicum can be increased.

In addition, mutations in one or more MCT genes of the invention can be used to prepare MCT proteins with altered activity that indirectly affect the production of one or more desired fine chemicals from Corynebacterium glutamicum. For example, the MCT protein of the present invention, which is involved in the discharge of waste products, can cause nucleotides and proteins to be damaged in cells by normal metabolic waste of the cells (which may be increased due to overproduction of the desired fine chemicals). Its number or activity can be increased so as to be effectively released prior to (e.g., reduced cell viability) or disrupting the fine chemical biosynthetic pathway (decreased yield, production or production efficiency of the desired fine chemical). In addition, relatively large amounts of fine chemicals in cells can themselves be toxic to cells, thereby increasing the viability of cells in culture by increasing the activity or number of carriers capable of excreting this compound from the longitudinal. In other words, it is possible to further increase the number of cells producing the desired fine chemicals in culture. The MCT protein of the invention may also be engineered to produce appropriate amounts of other lipid and fatty acid molecules. This can have a significant effect on the lipid composition of the cell membrane. Because each lipid type has different physical properties, changes in the lipid composition of the membrane can significantly change the fluidity of the membrane. Changes in membrane fluidity can affect cell integrity as well as transport of molecules through the membrane, all of which have a significant effect on the production of fine chemicals from Corynebacterium glutamicum in large-scale fermentation cultures.                 

The present invention relates to novel nucleic acid molecules encoding proteins referred to herein as MCT proteins, which may be involved, for example, in the metabolism of compounds required for the construction of a cell membrane in Corynebacterium glutamicum or the transport of molecules through the membrane. to provide. Nucleic acid molecules encoding MCT proteins are referred to herein as MCT nucleic acid molecules. In a preferred embodiment, the MCT protein is involved in the metabolism of compounds required for the construction of the cell membrane in Corynebacterium glutamicum or the transport of molecules through this membrane. Examples of such proteins include those encoded by the gene sets in Table 1 below.

Thus, one aspect of the invention relates to isolated nucleic acid molecules (eg, cDNA, DNA or RNA) comprising nucleotide sequences encoding MCT proteins or biologically active portions thereof, as well as MCT encoding nucleic acids (eg, DNA or nucleic acid fragments suitable as primers or hybridization probes for the detection or amplification of mRNA). In a particularly preferred embodiment, the isolated nucleic acid molecule is one of the nucleotide sequences described by the odd numbered sequences in the sequence listing (eg, SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 7 ...), or these nucleotide sequences One of the coding regions or its complement. In another particularly preferred embodiment, an isolated nucleic acid molecule of the invention is a nucleotide sequence described in the odd numbered sequence (e.g., SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 7 ....) or a portion thereof in the sequence listing. At least about 50%, preferably at least about 60%, more preferably at least about 70%, 80% or 90%, even more preferably at least about 95%, 96%, 97%, 98%, At least 99% or more homologous nucleotide sequences. In another preferred embodiment, the isolated nucleic acid molecule encodes one of the amino acid sequences set forth in the even-numbered sequence (eg, SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 8 ....) in the sequence list. Preferred MCT proteins of the invention also preferably have at least one of the MCT activities described herein.

In other embodiments, an isolated nucleic acid molecule encodes a protein or portion thereof, wherein the protein or portion thereof comprises an amino acid sequence having sufficient homology with an amino acid sequence of the invention (eg, an even number sequence in the sequence listing). Sequence), for example, an amino acid sequence having sufficient homology with the amino acid sequence of the present invention such that the protein or a portion thereof can maintain MCT activity. Preferably, the protein or portion thereof encoded by the nucleic acid molecule maintains the ability to participate in the metabolism of the compounds necessary for the construction of the cell membrane in Corynebacterium glutamicum or the transport of molecules through the membrane. In one embodiment, the protein encoded by the nucleic acid molecule is at least about 50%, preferably at least about 60%, of an amino acid sequence of the invention (eg, an entire amino acid sequence selected from those having even-numbered sequences in the sequence listing) , More preferably at least about 70%, 80% or 90%, most preferably at least about 95%, 96%, 97%, 98% or 99%, or more homologous. In another preferred embodiment, the protein is an open reading frame as represented by the entire amino acid sequence of the invention (the corresponding odd numbered sequence in the sequence listing (e.g., SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 7 ...). Is a full-length Corynebacterium glutamicum protein that is substantially homologous to).

In another preferred embodiment, the isolated nucleic acid molecule is from Corynebacterium glutamicum and is at least about 50% with one of the amino acid sequences of the invention (eg, one of even numbered sequences in the sequence listing). Or a biologically active domain having more homology and may be involved in the metabolism of compounds required for the construction of the cell membrane in Corynebacterium glutamicum or the transport of molecules through the membrane, or having one or more of the activities listed in Table 1. And encode a protein (eg, MCT fusion protein) that also comprises a heterologous nucleic acid sequence encoding a heterologous polypeptide or regulatory region.

In other embodiments, an isolated nucleic acid molecule hybridizes under stringent conditions with a nucleic acid molecule that is at least 15 nucleotides in length and comprises a nucleotide sequence of the invention (eg, an odd numbered sequence in the sequence listing). Preferably, the isolated nucleic acid molecule corresponds to a naturally occurring nucleic acid molecule. More preferably, the isolated nucleic acid encodes the MCT protein of Corynebacterium glutamicum or a biologically active site thereof.

Another aspect of the invention relates to vectors comprising nucleic acid molecules of the invention, such as recombinant vectors, and host cells into which such vectors are introduced. In one embodiment, the host cell is used to produce the MCT protein by culturing the host cell in a suitable medium. The MCT protein can then be isolated from the medium or host cell.

Another aspect of the invention relates to a genetically modified microorganism into which the MCT gene is introduced or mutated. In one embodiment, the genome of a microorganism is mutated by introducing a nucleic acid molecule of the invention encoding a wild type or mutant MCT sequence as a transgene. In other embodiments, the endogenous MCT gene in the genome of the microorganism is mutated by homologous recombination with the mutated MCT gene and, for example, functionally disrupted. In other embodiments, the endogenous or transgenic MCT gene in the microorganism is modified by one or more point mutations, deletions or inversions, but still encodes a functional MCT protein. In other embodiments, one or more regulatory regions (eg, promoters, repressors, or inducers) of the MCT gene in a microorganism (eg, deletion, truncation, inversion) Or by point mutations) to control the expression of the MCT gene. In a preferred embodiment, the microorganism belongs to the genus Corynebacterium or Brevibacterium, particularly preferably Corynebacterium glutamicum. In a preferred embodiment, the microorganism is also used for the production of the desired compound, such as amino acids, particularly preferably lysine.

In another aspect, the present invention provides a method of identifying the presence or activity of Corynebacterium diphtheria in a subject. Since the method involves detecting one or more nucleic acid or amino acid sequences of the invention in one subject (eg, the sequences listed in the Sequence Listing as SEQ ID NOs: 1-676), detecting the presence or activity of Corynebacterium diphtheria in the subject. can do.

Another aspect of the invention relates to an isolated MCT protein or portion thereof, eg, a biologically active site thereof. In a preferred embodiment, the isolated MCT protein, or portion thereof, functions in the production of energy molecules (eg, ATP) by processes such as metabolism or oxidative phosphorylation of carbon compounds such as sugars in Corynebacterium glutamicum. Can be done. In another preferred embodiment, the isolated MCT protein or portion thereof maintains the ability of Corynebacterium glutamicum to participate in the metabolism of compounds required for the construction of the cell membrane or the transport of molecules through the membrane. Some are sufficiently homologous to the amino acid sequences of the invention (eg, sequences of even sequence numbers in the sequence listing).

The present invention provides an isolated formulation of MCT protein. In a preferred embodiment, the MCT protein comprises the amino acid sequence of the invention (eg, even numbered sequences in the sequence listing). In another preferred embodiment, the invention relates to an isolated full-length protein (corresponding odd-numbered sequence in the sequence listing) that is substantially homologous to the entire amino acid sequence (even-numbered sequence in the sequence listing) of the present invention. Coded by). In another embodiment, the protein is at least about 50%, preferably at least about 60%, more preferably at least about 70%, 80 with the entire amino acid sequence of the invention (eg, even numbered sequences in the sequence listing) At least% or 90%, most preferably at least about 95%, about 96%, about 97%, about 98% or about 99%, or more homologous. In another embodiment, an isolated MCT protein comprises an amino acid sequence that is at least about 50% or more homologous to one of the amino acid sequences of the invention (eg, an even numbered sequence in the sequence listing) and comprises Corynebacte Inium glutamicum may be involved in the metabolism of compounds required for the construction of the cell membrane or the transport of molecules through the membrane, or have one or more of the activities listed in Table 1.

Alternatively, the isolated MCT protein may hybridize with, or be hybridized under, strict conditions, for example, at least about 50%, preferably at least about 60%, more preferably, with a nucleotide sequence of one of the even-numbered sequences listed in the Sequence Listing. Is encoded by at least about 70%, 80% or 90%, most preferably at least about 95%, about 96%, about 97%, about 98% or about 99%, or more homologous nucleotide sequences May comprise an amino acid sequence. It is also preferred that the preferred form of the MCT protein has one or more MCT bioactivity described herein.

The MCT polypeptide or its biologically active site can be operatively linked to a polypeptide other than the MCT polypeptide to form a fusion protein. In a preferred embodiment, the activity of this fusion protein differs from that of the MCT protein alone. In a preferred embodiment, this fusion protein is involved in the metabolism of compounds required for the construction of the cell membrane in Corynebacterium glutamicum or the transport of molecules through this membrane. In a particularly preferred embodiment, this fusion protein is introduced into a host cell to regulate the production of the desired compound from the host cell.

In another aspect, the invention provides a method for screening molecules that modulate the activity of an MCT protein by interacting with the MCT protein itself, a substrate or binding partner of the MCT protein, or by regulating the transcription or translation of an MCT nucleic acid molecule of the invention. Provide a method.

Another aspect of the present invention is directed to a process for the manufacture of fine chemicals. This method involves culturing cells comprising a vector expressing the MCT nucleic acid molecule of the present invention to produce fine chemicals. In a preferred embodiment, the method also comprises transfecting the cells with a vector expressing an MCT nucleic acid to obtain a cell containing said vector. In another preferred embodiment, the method also includes recovering fine chemicals from the culture. In particularly preferred embodiments, the cells are from the Corynebacterium or Brevibacterium genus or selected from the strains described in Table 3.

Another aspect of the invention relates to a method by which molecules from the microorganism regulate production. Such methods include contacting a cell with a substance that modulates MCT protein activity or MCT nucleic acid expression such that cell related activity changes relative to the activity in the absence of the substance. In a preferred embodiment, cells are regulated for one or more metabolic pathways to the cell membrane components of Corynebacterium glutamicum or for the transport of compounds through the membrane, thereby improving the yield or production rate of the desired fine chemicals by this microorganism. Let's do it. A substance that modulates MCT protein activity may be a substance that stimulates MCT protein activity or MCT nucleic acid expression. Examples of substances that stimulate MCT protein activity or MCT nucleic acid expression include small molecules, active MCT proteins, and nucleic acids encoding MCT proteins introduced into cells. Examples of substances that inhibit MCT activity or expression include small molecules and antisense MCT nucleic acid molecules.

Another aspect of the invention relates to a method of modulating the yield of a desired compound from a cell comprising introducing a wild type or mutant MCT gene into the cell such that it is maintained on a separate plasmid or introduced into the genome of the host cell. will be. Once inserted into the genome (this insertion can be random or can be caused by homologous recombination that allows the native gene to be replaced by an introduced copy) to regulate the production of the desired compound from the cell. In a preferred embodiment, the yield is increased. In another preferred embodiment, the chemical is a fine chemical. In a particularly preferred embodiment, the fine chemical is an amino acid. In a particularly preferred embodiment said amino acid is L-lysine.

The present invention provides MCT nucleic acid and protein molecules involved in the metabolism of cell membrane components or the transport of compounds through the membrane in Corynebacterium glutamicum. Molecules of the invention can be used to directly regulate the production of fine chemicals from microorganisms such as Corynebacterium glutamicum (eg, Corynebacterium in which overexpression or optimization of fatty acid biosynthetic proteins is modified Directly affect the yield, production, and / or production efficiency of fatty acids from glutamicum, or indirectly affect the increase in yield, production and / or production efficiency of the desired compound ( For example, metabolic regulation of cell membrane components changes yield, production and / or production efficiency, or composition of the cell membrane, i.e., may affect the production of one or more fine chemicals). Aspects of the invention are described in more detail below.

I. Fine Chemicals

The term "fine chemical" is well known in the art and includes molecules produced by living organisms used in a variety of industries, such as, but not limited to, the pharmaceutical, agricultural and cosmetic industries. Such compounds include organic acids such as tartaric acid, itaconic acid and diamino pimelic acid, proteomic and nonproteinaceous amino acids, purine and pyrimidine bases, nucleosides, and nucleotides [see, eg, Kuninaka, A. (1996) Nucleotides and related compounds, p. 561-612, in Biotechnology vol. 6, Rehm et al., Eds. Fatty acids (eg arachidonic acid), diols (eg propanediol and butanediol), carbohydrates (eg hyaluronic acid and trehalose), aromatic compounds (eg aromatic amines, vanillin and indigo), vitamins and auxiliary Factors (Ullmann's Encyclopedia of Industrial Chemistry, vol. A27, "Vitamins", p. 443-613 (1996) VCH: Weinheim) and references included therein; And Ang, AS, Niki, E. & Packer, L. (1995) "Nutrition, Lipids, Health, and Disease" Proceedings of the UNESCO / Confederation of Scientific and Technological Associations in Malaysia, and the Society for Free Radical Research Asia, held Sept. 1-3, 1994 at Penang, Malaysia, AOCS Press, (1995)], enzymes, polypeptides (Cane et al. (1998) Science 282: 63-68), and Gutcho (1983) Chemicals by Fermentation, Noyes Data Corporation, ISBN: 0818805086) and all other chemicals described in the references therein The metabolism and use of some of these fine chemicals will be described in more detail below.

A. Amino Acid Metabolism and Uses

Amino acids make up the basic structural unit of every protein and are essential for normal cellular function in all living organisms. The term "amino acid" is recognized in the art. While 20 proteinogenic amino acids in amino acids act as structural units for the proteins to which they are bound by peptide bonds, nonproteinogenic amino acids (hundreds of them are known) are not normally found in proteins. Ulmann's Encyclopedia of Industrial Chemistry, vol. A2, p. 57-97 VCH: See Weinheim (1985). Although L-amino acids are generally the only form found in naturally occurring proteins, amino acids can be either D-optical or L-optical structures. The biosynthesis and degradation pathways of each of the 20 proteinogenic amino acids are well characterized in both prokaryotic and eukaryotic cells (see, eg, Stryer, L. Biochemistry, 3rd edition, pages 578-590 (1988)). Reference]. Amino acids called "essential" amino acids (histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine) are common nutritional requirements due to the complexity of biosynthesis. Easily converted to amino acids (alanine, arginine, asparagine, aspartate, cysteine, glutamate, glutamine, glycine, proline, serine and tyrosine). Higher animals have the ability to synthesize some of the essential amino acids, but these essential amino acids must be supplied from meals in order for normal protein synthesis to occur.

In addition to the function of amino acids in protein biosynthesis, these amino acids are themselves interesting chemicals, and many amino acids have been found to be used in a variety of applications in the food, feed, chemical, cosmetic, agricultural and pharmaceutical industries. Lysine is an important amino acid not only in humans but also in the nutrition of unit animals such as poultry and swine. Glutamate is most commonly used as a flavourant additive (mono-sodium glutamate, MSG), and aspartate, phenylalanine, glycine and citrate are also widely used throughout the food industry. Glycine, L-methionine and tryptophan are all used in the pharmaceutical industry. Glutamine, valine, leucine, isoleucine, histidine, arginine, proline, serine and alanine are used in both the pharmaceutical and cosmetic industries. Threonine, tryptophan and D / L-methionine are common feed additives (Leuchtenberger, W. (1996) Amino acids technical production and use, p. 466-502 in Rehm et al. (Eds.) Biotechnology vol. 6, chapter 14a, VCH: Weinheim). In addition, these amino acids are synthetic amino acids and proteins such as N-acetylcysteine, S-carboxymethyl-L-cysteine, (S) -5-hydroxytryptophan, and Ulmann's Encyclopedia of Industrial Chemistry, vol. A2, p. 57-97, VCH: Weinheim, 1985), have been found to be useful as precursors for the synthesis of others.

The characterization of the biosynthesis of these natural amino acids in organisms capable of producing these natural amino acids, such as bacteria, is well characterized [see Bacterial Amino Acid Biosynthesis and its Regulation for details in Umbarger, HE (1978) Ann. Rev. Biochem 47: 533-606). Glutamate is synthesized by reduction amination of α-ketoglutarate, which is an intermediate of the citric acid cycle. Glutamine, proline and arginine are each produced from glutamate. Biosynthesis of serine begins with 3-phosphoglycerate (an intermediate of its action) and is a three step process of producing serine after oxidation, transaminoation and hydrolysis steps. Both cysteine and glycine are produced from serine, which is produced by the condensation of homocysteine and serine, and glycine is produced by the transfer of side chain β-carbon atoms to tetrahydrofolate in a reaction catalyzed by serine transhydroxymethylase. . Phenylalanine and tyrosine are synthesized from erythrose 4-phosphate and phosphoenolpyruvate, which are glycolysis and pentose phosphate pathway precursors in the nine-step biosynthetic pathway that differ only in the final two steps after the synthesis of the prephenate. Tryptophan is also synthesized from these two initial molecules, but its synthesis is an 11 step pathway. Tyrosine may also be synthesized from phenylalanine in a reaction catalyzed by phenylalanine hydroxylase. Alanine, valine and leucine are all biosynthetic products of pyruvate, the final product of glycolysis. Aspartate is formed from oxaloacetate, the intermediate of the citric acid cycle. Asparagine, methionine, threonine and lysine are each produced by the conversion of aspartate. Isoleucine is formed from threonine. Histidine is produced from 5-phosphoribosyl-1-pyrophosphate, an activated sugar in a complex nine-step pathway.

Amino acids in excess of the cell's protein synthesis requirements cannot be stored, but instead are degraded to serve as intermediates for the cell's major metabolic pathways [see, for example, Stryer, L. Biochemistry 3rd ed. Ch. 21 "Amino Acid Degradation and the Urea Cycle "p. 495-516 (1988)). Although cells can convert unnecessary amino acids into useful metabolic intermediates, amino acid production is a lossy synthesis given the energy, precursor molecules, and enzymes required to synthesize these amino acids. Thus, it is not surprising that the presence of a particular amino acid regulates the biosynthesis of the amino acid by feedback inhibition, which slows or completely stops its own production. For a complete discussion of the feedback mechanism of the amino acid biosynthetic pathway, see Stryer, L. Biochemistry 3rd ed. Ch. 24 "Biosynthesis of Amino Acids and Heme" p. 575-600 (1988)). Thus, the yield of any particular amino acid is limited by the amount of amino acid present in the cell.

B. Metabolism and Uses of Vitamins, Cofactors and Nutritional Supplements

Vitamins, cofactors, and nutrients, although easily synthesized by other organisms such as bacteria, constitute another group of molecules that higher animals have to lose because of their ability to synthesize. These molecules are themselves bioactive materials or precursors of biologically active materials that can act as electron carriers or intermediates in various metabolic pathways. In addition to their nutritional value, these compounds have considerable industrial value as pigments, antioxidants and catalysts, or as auxiliaries for other processes (for the structure, activity and industrial use of these compounds, see, for example, Ullman's Encyclopedia of Industrial). Chemistry, "Vitamins" vol.A27, p. 443-613, VCH: Weinheim, 1996)] The term "vitamin" is recognized in the art and is necessary for the normal functioning of an organism, but the organism synthesizes itself. The group of vitamins may also include cofactors and nutrient compounds The term "cofactor" includes nonproteinaceous compounds necessary for normal enzymatic activity to occur. It is preferred that the cofactor molecule of the invention is organic The term "nutritive" refers to health benefits for plants and animals, especially humans One dietary supplement Examples of such molecules are vitamins, antioxidants and some lipids (eg, polyunsaturated fatty acids).

The biosynthesis of these molecules occurring in organisms capable of producing them, such as bacteria, is well characterized (Ullman's Encyclopedia of Industrial Chemistry, "Vitamins" vol. A27, p. 443-613, VCH: Weinheim, 1996; Michal , G. (1999) Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology, John Wiley &Sons; Ong, AS, Niki, E. & Packer, L. (1995) "Nutrition, Lipids, Health, and Disease" Proceedings of the UNESCO / Confederation of Scientific and Technological Associations in Malaysia, and the Society for Free Radical Research-Asia, held Sept. 1-3, 1994 at Penang, Malaysia, AOCS Press: Champaign, IL X, 374 S).

Thiamine (vitamin B ₁ ) is produced by chemical coupling of pyrimidine and thiazole residues. Riboflavin (vitamin B ₂ ) is synthesized from guanosine-5'-triphosphate (GTP) and ribose-5'-phosphate. Riboflavin is then used for the synthesis of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). Compound groups collectively referred to as "vitamin B ₆ " (eg, pyridoxine, pyridoxamine, pyridoxa-5'-phosphate and commercially available pyridoxine hydrochloride) are all typical structural units of 5-hydroxy-6- Derivatives of methylpyridine. Pantothenate (pantothenic acid, (R)-(+)-N- (2,4-dihydroxy-3,3-dimethyl-1-oxobutyl) -β-alanine) is produced by chemical synthesis or fermentation Can be. The final stage of biosynthesis of pantothenate consists of ATP-induced condensation of β-alanine and pantosan. Biosynthesis steps for converting to pantosan, biosynthesis steps for converting to β-alanine, and enzymes involved in condensation to pantothenic acid are known. The metabolic active form of pantothenate is coenzyme A, the biosynthesis for coenzyme A proceeds in a five step enzymatic reaction. Pantothenate, pyridoxal-5'-phosphate, cysteine and ATP are precursors of coenzyme A. These enzymes not only catalyze the formation of pantothenate, but also (R) -pantosan, (R) -pantolactone, (R) -panthenol (provitamin B ₅ ), pantethene (and derivatives thereof) and coenzymes. The production of A also catalyzes.

Biosynthesis of biotin from pimeloyl-CoA, the precursor molecule in microorganisms, has been studied in detail and several related genes have been identified. A number of corresponding proteins have been found to be involved in Fe-cluster synthesis as well, and these proteins are members of nifS class proteins. Lipoic acid is derived from octanoic acid and acts as a coenzyme in energy metabolism, which is part of the pyruvate dehydrogenase conjugate and α-ketoglutarate dehydrogenase conjugate in energy metabolism. Folates are all a group of derivative materials of folic acid, and folic acid is derived from L-glutamic acid, p-amino-benzoic acid and 6-methylphtherine. Biosynthesis of folic acid and its derivatives, starting from the metabolic intermediate guanosine-5′-triphosphate (GTP), L-glutamic acid and p-amino-benzoic acid, has been studied in detail in some microorganisms.

Corinoids (eg cobalamin and especially vitamin B ₁₂ ) and porphyrins belong to the group of chemicals characterized by the tetrapyrrole ring system. The biosynthesis of vitamin B ₁₂ is sufficiently complex in that many enzymes and substrates are now known, although their characteristics are not fully characterized. Nicotinic acid (nicotinate) and nicotinamide are pyridine derivatives, also referred to as "niacin". Niacin is an important coenzyme NAD (nicotinamide adenine dinucleotide), NADP (nicotinamide adenine dinucleotide phosphate) and their reduced precursors.

Mass production of these compounds relies mainly on cell-free chemical synthesis, although some of these chemicals, such as riboflavin, vitamin B ₆ , pantothenate and biotin, are also produced by mass culture of microorganisms. Only vitamin B ₁₂ is produced entirely by fermentation due to the complexity of the synthesis of vitamin B ₁₂ . In vitro methodologies require significant inputs of material and time, often of high cost.

C. Metabolism and Uses of Purines, Pyrimidines, Nucleosides, and Nucleotides

Purine and pyrimidine metabolic genes and their corresponding proteins are important targets for the treatment of tumor diseases and viral infections. The term "purine" or "pyrimidine" includes nitrogen containing bases that are components of nucleic acids, coenzymes and nucleotides. The term "nucleotide" includes the basic structural unit of a nucleic acid molecule, consisting of a nitrogen containing base, an pentose sugar (for RNA, said sugar is ribose; for DNA, said sugar is D-deoxyribose) and phosphoric acid. The term “nucleoside” includes molecules that act as precursors of nucleotides but are free of phosphate residues possessed by the nucleotides. By inhibiting the biosynthesis of these molecules or inhibiting the recruitment of these molecules to form nucleic acid molecules, it is possible to inhibit RNA and DNA synthesis; By inhibiting this activity in a manner that targets cancer cells, the ability to divide and replicate tumor cells can be suppressed. There are also nucleotides that act as energy stores (ie, AMPs) or coenzymes (ie, FAD and NAD) rather than form nucleic acid molecules.

It has been described in the literature that these chemicals can be used in these medical conditions by influencing purine and / or pyrimidine metabolism (eg, Christopherson, RI and Lyons, SD (1990) "Potent inhibitors of de novo pyrimidine and purine biosynthesis as chemotherapeutic agents. "Med. Res. Reviews 10: 505-548). The study of enzymes involved in purine and pyrimidine metabolism has focused on the development of new drugs that can be used, for example, as immunosuppressive or antiproliferative agents (Smith, JL, (1995) "Enzymes in nucleotide synthesis." Curr. Opin.Struct. Biol. 5: 752-757; (1995) Biochem Soc. Transact. 23: 877-902). However, purine and pyrimidine bases, nucleosides and nucleotides are used as intermediates in the biosynthesis of various fine chemicals (e.g., thiamin, S-adenosyl-methionine, folate or riboflavin), energy for cells As a carrier (e.g., ATP or GTP), and for the chemical itself, which is usually used as a fragrance enhancer (e.g., IMP or GMP) or for various medical uses [e.g., literature (See Kuninaka, A. (1996) Nucleotides and Related Compounds in Biotechnology vol. 6, Rehm et al., Eds. VCH: Weinheim, p. 561612). In addition, there is an increasing number of studies to develop crop protection chemicals, including fungicides, herbicides and pesticides, by targeting enzymes involved in purine, pyrimidine, nucleoside or nucleotide metabolism.

The metabolism of these compounds in bacteria has been characterized (see, for example, Zalkin, H. and Dixon, JE (1992) "de novo purine nucleotide biosynthesis", in: Progress in Nucleic Acid Research and Molecular Biology, vol. 42, Academic Press :, p. 259-287; and Michal, G. (1999) "Nucleotides and Nucleosides", Chapter 8 in: Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology, Wiley: New York )). Purine metabolism is the subject of intensive research and is essential for the normal functioning of cells. Impaired purine metabolism in higher animals can lead to serious diseases such as gout. Purine nucleotides are subjected to ribose-5- in a series of steps through inosine-5'-phosphate (IMP), an intermediate compound that produces guanosine-5'-monophosphate (GMP) or adenosine-5'-monophosphate (AMP). Triphosphates that are synthesized from phosphates and used as nucleotides from these GMPs or AMPs are readily formed. Since these compounds are also used as energy stores, their degradation provides energy for many different biosynthetic processes in the cell. Pyrimidine biosynthesis proceeds by the formation of uridine-5'-monophosphate (UMP) from ribose-5-phosphate. UMP is then converted to cytidine-5'-triphosphate (CTP). The deoxy form of all these nucleotides is produced in a one step reduction reaction in which the diphosphate ribose form of nucleotide is converted to the diphosphate deoxyribose form of nucleotide. Upon phosphorylation, these molecules may be involved in DNA synthesis.

D. Metabolism and Uses of Trehalose

Trehalose consists of two sugar molecules bound by α, α-1,1 bonds. Trehalose is commonly used in the food industry and the beverage industry as an additive for sweeteners, dried or frozen foods. However, it is also used in the pharmaceutical, cosmetic and biotechnology industries [see, for example, Nishimoto et al., (1998) US Pat. No. 5,759,610; Singer, MA and Lindquist, S. (1998) Trends Biotech. 16: 460467 Paiva, CLA and Panek, AD (1996) Biotech. Ann. Rev. 2: 293-314; and Shiosaka, M. (1997) J. Japan 172: 97-10). Trehalose is produced by enzymes from a number of microorganisms and naturally released into the surrounding medium, which can be obtained from the medium using methods known in the art.

II. Membrane Biosynthesis and Transmembrane Transport

The cell membrane performs various functions in the cell. First, the cell membrane separates the cell contents from the surrounding environment, thus imparting integrity to the cells. Membranes can also act as a barrier to the influx of dangerous or unwanted compounds as well as the outflow of the desired compounds. Cell membranes are inherently hydrophobic compounds, such as proteins, water molecules, due to their structure that the polar head groups are facing outwards (toward the inside and outside of the cells, respectively) and the nonpolar tails are towards the center of the bilayer to form a hydrophobic core and Impermeable to non-promoting diffusion of ions (generally, for investigation of membrane structure and function, see Gennis, RB (1989) Biomembranes, Molecular Structure and Function, Springer: Heidelberg). This barrier allows cells to maintain higher concentrations of the desired compounds and lower concentrations of unwanted compounds than those contained in the surrounding medium, which effectively prevents the diffusion of these compounds by the membrane. Because. However, the membrane also exists as an effective barrier to the influx of the desired compound and the discharge of the lung molecules. To overcome this difficulty, cell membranes contain many types of carrier proteins that can facilitate transmembrane transport of different types of compounds to the membrane. Such carrier proteins are of two general types: pores or channels and carriers. The pores or channels are whole membrane proteins, sometimes protein complexes, that form regulatory pores through the membrane. Such regulation or 'gating' is generally specific for the molecule to be carried by the pore or channel (this transmembrane structure is selectively permeable to certain kinds of substrates), for example potassium channels have similar charges. And only ions having a size can pass therethrough. Channel and pore proteins are separated hydrophobic and hydrophilic so that the hydrophobic side of the protein binds to the inside of the membrane while the hydrophilic side is lined inside the channel to provide a protected hydrophilic environment through which selected hydrophilic molecules can pass. There is a tendency to have domains. Many such pores / channels are known in the art, including those for potassium, calcium, sodium and chloride ions.

The above pore and channel-mediated systems for accelerated diffusion are limited to very small molecules, such as ions, which pass through smaller hydrophilic molecules with a pore or channel of sufficient size to pass the entire protein by facilitated diffusion. Because you can not stop. The transport of molecules by this process is sometimes referred to as 'promoting diffusion' because it requires the power of a concentration gradient. Permease also allows for the facilitating diffusion of larger molecules such as these (also referred to as 'uniports') into cells when the concentration of glucose or other sugars is greater on one side of the cell than on the other. . In contrast to pores or channels, these entire membrane proteins (often with 6 to 14 transmembrane α-helices) bind to the target molecule at the surface of the membrane rather than form open channels through the membrane, and then the target molecule is opposite the membrane. Morphological changes are made to release laterally.

However, cells often need to be brought in or out of the molecule ('active transport') against concentration gradients that exist in situations where accelerated diffusion cannot occur. There are two common mechanisms used by cells for such membrane transport, namely seam or antipot, and energy-linked transport such as mediated by ABC carriers. The Simport and Antiport systems connect the movement of two different molecules across the membrane (via a permease with two separate binding sites for two different molecules); In Simport, two molecules are transported in the same direction, but in Antiport, one molecule enters and the other flows out. In terms of energy, this transport is possible because one of the two molecules moves in a concentration gradient, and this advantageous action in terms of energy is only allowed when simultaneously moving the desired compound against the predominant concentration gradient. Single molecules can be transported through the membrane against a concentration gradient in energy-propelling processes such as those employed by ABC carriers. In this system, the carrier protein located on the membrane has an ATP-binding cassette, which, when the target molecule binds, converts the ATP to ADP + Pi, and thus the opposite side of the membrane that is promoted by the carrier by using the released energy. To promote the movement of the target molecule into the. For a more detailed description of all these delivery systems see Bamberg, E. et al., (1993) "Charge transport of ion pumps on lipid bilayer membranes", Q. Rev. Biophys. 26: 1-25; Findlay, J. B. C. (1991) "Structure and function in membrane transport systems", Curr. Opin. Struct. Biol. 1: 804-810; Higgins, C. F. (1992) "ABC transporters from microorganisms to man", Ann. Rev. Cell Biol. 8: 67-113; Gennis, R. B. (1989) "Pores, Channels and Transporters", in: Biomembranes, Molecular Structure and Function, Springer: Heidelberg, p. 270-322; and Nikaido, H. and Saier, H. (1992) "Transport proteins in bacteria: common themes in their design", Science 258: 936-942 and references included in each of these references.

The synthesis of membranes is a well established process involving many components, the most important of which are lipid molecules. Lipid synthesis can be divided into two parts: synthesis of fatty acids and attachment of fatty acids to sn-glycerol-3-phosphate, and addition or modification of polar head groups. Typical lipids used in bacterial membranes include phospholipids, glycolipids, sphingolipids and phosphoglycerides. Fatty acid synthesis begins by converting acetyl CoA to malonyl CoA by acetyl CoA carboxylase and acetyl-ACP by acetyltransacylase, respectively. Following the condensation reaction, these two product molecules together form acetoacetyl-ACP, which are converted by a series of condensation, reduction and dehydration reactions to produce saturated fatty acid molecules with the desired chain length. The production of unsaturated fatty acids from these molecules is promoted aerobic or anaerobic with the help of oxygen molecules by specific unsaturated enzymes. C. Neidhardt et al. (1996) E. coli and Salmonella. ASM Press: Washington, D. C., p. 612-636 and references contained therein; Lengeler et al. (eds) (1999) Biology of Procaryotes. Thieme: Stuttgart, New York, and references contained therein; and Magnuson, K. et al., (1993) Microbiological Reviews 57: 522-542 and references included therein. Cyclopropane fatty acids (CFAs) are synthesized by specific CFA-synthase using SAM as substrate. Branched chain fatty acids are synthesized from branched chain amino acids that are deamined to produce branched 2-oxo-acids. [Lengeler et al., Eds. (1999) Biology of Procaryotes. Thieme: Stuttgart, New York, and references included herein. Another essential step in lipid synthesis is the transfer of fatty acids onto polar head groups, for example by glycerol-phosphate-acyltransferase. Various precursor molecules and biosynthetic enzymes are used in combination to produce several fatty acid molecules that greatly affect the composition of the membrane.

III. Elements and Methods of the Invention

  The present invention is based, in part, on the discovery of new molecules referred to herein as MCT nucleic acid and protein molecules, which regulate cell membrane formation in Corynebacterium glutamicum and regulate the transport of molecules through this membrane. In one embodiment, the MCT molecule is involved in the metabolism of compounds required for the construction of the cell membrane in Corynebacterium glutamicum and the transport of molecules through the membrane. In a preferred embodiment, the activity of the MCT molecules of the invention that regulate the production and membrane transport of the membrane components affects the production of the desired fine chemicals by this organism. In a particularly preferred embodiment, the Corynebacterium glutamicum metabolic pathway regulated by the MCT protein of the invention is regulated in terms of yield, production and / or production efficiency, and the transport efficiency of the compound across the membrane is altered The bacterium glutamicum modulates the activity of the MCT molecules of the present invention to directly or indirectly regulate the yield, production and / or production efficiency of the desired fine chemical production.

The term "MCT protein" or "MCT polypeptide" includes proteins involved in the metabolism of compounds required for the construction of Corynebacterium glutamicum cell membranes, or the transport of molecules through this membrane. Examples of MCT proteins include those encoded by the MCT genes listed in Table 1 and odd sequence number sequences. The term "MCT gene" or "MCT nucleic acid sequence" includes nucleic acid sequences encoding MCT proteins, consisting of coding regions and corresponding untranslated 5 'and 3' sequence regions. Examples of MCT genes include those listed in Table 1. The term “production” or “productivity” is a term recognized in the art and includes the concentration of fermentation product (eg, kg product per liter per hour) formed within a given time and within a given fermentation volume. . The term "production efficiency" includes the time required to achieve a specific product concentration (eg, the time it takes for a cell to obtain a specific proportion of fine chemical product). The term "yield" or "product / carbon yield" is a term recognized in the art and includes conversion efficiency of carbon sources to products (ie, fine chemicals). This term is generally denoted, for example, kg product per kg carbon source. By increasing the yield or yield of the compound, the amount of recovered molecules or useful molecules of the compound in the obtained amount of culture obtained for a given time is increased. The term "biosynthesis" or "biosynthetic pathway" is a term recognized in the art and involves the synthesis of compounds, preferably organic compounds, from intermediate compounds by cells, and can be a multistep highly regulated process. The term "degradation" or "degradation pathway" is a term recognized in the art and includes the degradation by a cell into a degradation product of a compound, preferably an organic compound (generally, a molecule of smaller or less complex structure) and This can be a multi-step, highly controlled process. Subsequent metabolism of certain compounds (eg, metabolism of amino acids such as glycine) includes the overall biosynthesis, modification, and degradation pathways of cells associated with such compounds.

In another embodiment, the MCT molecules of the invention can modulate the production of the desired molecule, such as fine chemicals, in a microorganism such as Corynebacterium glutamicum. There are a number of mechanisms in which the modification of the MCT molecules of the present invention can directly affect the yield, yield and / or production efficiency of fine chemical production from Corynebacterium glutamicum strains incorporating modified proteins. Such MCT proteins, which are involved in the release of fine chemical molecules from cells, can be increased in number or activity so that more of these compounds are secreted into the extracellular medium from which they are more readily recovered. Similarly, MCT proteins that are involved in the influx of nutrients necessary for biosynthesis of one or more fine chemicals (eg, phosphate, sulfate nitrogen compounds, etc.) may increase intracellular concentrations of these precursors, cofactors, or intermediates. If possible, its number or activity may be increased. In addition, the fatty acids and lipids themselves are preferred fine chemicals, and by optimizing the activity of or increasing the number of one or more MCT proteins of the present invention involved in the biosynthesis of such compounds, or one involved in the degradation of these compounds. By impairing the activity of the above MCT protein, the yield, production and / or production efficiency of fatty acid and lipid molecules from Corynebacterium glutamicum can be increased.

Mutagenesis of one or more MCT genes of the present invention may also produce MCT proteins with altered activity that directly affect the production of one or more desired fine chemicals from Corynebacterium glutamicum. For example, the MCT protein of the present invention, which is involved in the discharge of waste products, can cause nucleotides and proteins to be damaged in cells by normal metabolic waste of the cells (which may be increased due to overproduction of the desired fine chemicals). Its number or activity can be increased so as to be effectively released prior to (e.g., reduced cell viability) or disrupting the fine chemical biosynthetic pathway (decreased yield, production or production efficiency of the desired fine chemical). In addition, relatively large amounts of fine chemicals in cells can themselves be toxic to cells, thereby increasing the viability of cells in culture by increasing the activity or number of carriers capable of excreting this compound from the longitudinal. In other words, it is possible to further increase the number of cells producing the desired fine chemicals in culture. The MCT protein of the invention may also be engineered to produce appropriate amounts of other lipid and fatty acid molecules. This can have a significant effect on the lipid composition of the cell membrane. Because each lipid type has different physical properties, changes in the lipid composition of the membrane can significantly change the fluidity of the membrane. Changes in membrane fluidity can affect cell integrity as well as the transport of molecules through the membrane, both of which significantly affect the production of fine chemicals from Corynebacterium glutamicum in large-scale fermentation cultures.

Isolated nucleic acid sequences of the present invention are contained within the genome of Corynebacterium glutamicum strains that are available from the American Type Culture Collection, designated ATCC13032. The nucleotide sequence of the isolated Corynebacterium glutamicum MCT DNA and the expected amino acid sequence of the Corynebacterium glutamicum MCT protein are shown in the sequence listing as odd sequence numbers and even sequence numbers, respectively. Computer analysis was performed to classify and / or identify such nucleotide sequences as sequences encoding proteins involved in the metabolism of cell membrane components or proteins involved in the transport of compounds through the membrane.

The invention also relates to a protein having an amino acid sequence that is substantially homologous to an amino acid sequence of the invention (eg, a sequence of even sequence numbers in the sequence listing). As used herein, a protein having an amino acid sequence that is substantially homologous to the selected amino acid sequence is at least about 50% homologous to the selected amino acid, eg, the entire amino acid sequence selected. A protein having an amino acid sequence that is substantially homologous to the amino acid sequence selected is about 50 to 60% or more, preferably about 60 to 70% or more, more preferably about 70 to 80%, 80 to 80, based on the amino acid sequence selected. 90%, or at least 90-95%, most preferably at least about 96%, at least 97%, at least 98%, at least 99% homology.

The MCT protein of the present invention or a biologically active portion or fragment thereof is involved in the metabolism of compounds required for the construction of a cell membrane in Corynebacterium glutamicum or the transport of molecules through this membrane, or at least one of the activities listed in Table 1. Can have

Various aspects of the invention are described in more detail in the following subsections.

A. Isolated Nucleic Acid Molecules

One aspect of the invention provides for use as hybridization probes or primers for identifying or amplifying MCT-encoding nucleic acids (eg, MCT DNA), as well as isolated nucleic acid molecules encoding MCT polypeptides or biologically active portions thereof. Enough nucleic acid fragments. As used herein, the term “nucleic acid molecule” includes DNA or RNA analogs generated using DNA molecules (eg cDNA or genomic DNA), RNA molecules (eg mRNA), and nucleotide analogues. I mean. The term also includes untranslated sequences located at both the 3 'and 5' ends of the coding region of the gene, at least about 100 nucleotide sequences upstream from the 5 'end of the coding region, and 3' of the coding region of the gene. At least about 20 nucleotide sequences downstream from the terminus. The nucleic acid molecule may be single stranded or double stranded, preferably double stranded DNA. An “isolated” nucleic acid molecule is one that is separated from other nucleic acid molecules present in a natural source of nucleic acid. Preferably, an “isolated” nucleic acid does not have a sequence that is native to both sides of the nucleic acid (ie, sequences located at the 5 ′ and 3 ′ ends of the nucleic acid) in the genomic DNA of the organism from which it is derived. For example, in various embodiments, an isolated MCT nucleic acid molecule is about 5 kb on both sides of the original nucleic acid molecule in the genomic DNA of the cell from which it is derived (eg, Corynebacterium glutamicum cells), Nucleotide sequences of size less than 4 kb, 3 kb, 2 kb, 1 kb, 0.5 kb or 0.1 kb. In addition, an “isolated” nucleic acid molecule, eg, a DNA molecule, is substantially free of other cellular material or culture medium when produced by recombinant technology, or chemical precursors or other chemicals when chemically synthesized. .

Standard molecular biology techniques and the sequence information provided herein can be used to isolate nucleic acid molecules of the invention, eg, nucleic acid molecules having nucleotide sequences of odd sequence numbers in the sequence listing, or portions thereof. For example, all or part of one of the sequences of odd sequence numbers in the sequence listing can be used as hybridization probes and standard hybridization techniques (eg, Sambrook, J., Fritsh, EF, and Maniatis T. Molecular Cloning: A Laboratory Manual.2nd, ed., Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989), using Corynebacterium from Corynebacterium glutamicum libraries using a hybridization technique. Leeum glutamicum MCT DNA can be isolated. Furthermore, nucleic acid sequences of the invention (e.g., sequences of odd sequence numbers in the sequence listing) by polymerase chain reaction using oligonucleotide primers designed based on the same sequences Nucleic acid sequences of the invention (e.g., sequences of odd sequence numbers) by polymerase chain reaction using oligonucleotide primers designed on the basis of Nucleic acid molecules comprising all or part of one of For example, mRNA can be isolated from normal endothelial cells (eg, by guanidinium-thiocyanate extraction method of Chilgwin et al. (1979) Biochemistry 18: 5294-5299), and DNA Is a reverse transcriptase (e.g., Moloney MLV reverse transcriptase available from Gibco / BRL (Bethesda, MD); or from Seikagaku America, Inc., St. Petersburg, FL) Available AMV reverse transcriptase). Synthetic oligonucleotide primers can be designed for amplifying polymerase chain reactions based on one of the nucleotide sequences listed in the sequence listing. Nucleic acids of the invention can be amplified using cDNA or, alternatively, genomic DNA as a template and using appropriate oligonucleotide primers according to standard PCR amplification techniques. The nucleic acid thus amplified can be cloned into an appropriate vector and characterized by DNA sequencing. In addition, oligonucleotides corresponding to MCT nucleotide sequences can be prepared using standard synthetic techniques, such as automated DNA synthesizers.

In a preferred embodiment, the isolated nucleic acid molecules of the invention comprise one of the nucleotide sequences described in the sequence listing. Nucleic acid sequences of the invention as described in the Sequence Listing correspond to Corynebacterium glutamicum MCT DNA of the invention. This DNA contains the 5 'untranslated and 3' untranslated sequences represented by each odd sequence number sequence in the sequence listing as well as the sequence encoding the MCT protein (ie, the "coding region" shown in the sequence of odd sequence numbers in the sequence listing). It also includes sequences. Alternatively, the nucleic acid molecule may comprise only the coding region of one of the nucleic acid sequences of the sequence listing.

For the purposes of the present application, each of the nucleic acid and amino acid sequences set forth in the Sequence Listing is RXA, RXN, RXS or RXC for identification having the names "RXA", "RXN", "RXS" or "RXC" followed by five numbers. It will be understood to have a number (ie, RXA02099, RXN03097, RXS00148 or RXC01748). Each nucleic acid sequence consists of three parts, the 5 'upstream region, the coding region and the downstream region. To avoid confusion, each of these three regions is identified by the same RXA, RXN, RXS or RXC name. In addition, “one of the odd sequences in the sequence listing” means any of the nucleic acid sequences in the sequence listing, and may also be distinguished by their other RXA, RXN, RXS or RXC names. The coding region of each of these sequences is also translated into the corresponding amino acid which is described by the even sequence number in the sequence listing (the corresponding nucleic acid sequence is described below). For example, the coding region for RXA03097 is set forth in SEQ ID NO: 1 and the amino acid sequence it encodes is set forth in SEQ ID NO: 2. The sequences of the nucleic acid molecules of the invention are identified by the same RXA, RXN, RXS or RXC name as the amino acid molecule they encode so that they can be easily interrelated. For example, the amino acid sequences designated RXA02099, RXN03097, RXS00148, and RXC01748 are translations of the coding region of the nucleotide sequences of the nucleic acid molecules RXA02099, RXN03097, RXS00148, and RXC01748, respectively. The correspondence between the RXA, RXN, RXS and RXC nucleotide and amino acid sequences of the present invention and their assigned sequence numbers is set forth in Table 1. For example, as shown in Table 1, the nucleotide sequence of RXA00104 is shown in SEQ ID NO: 5 and the amino acid sequence of RXA00104 is shown in SEQ ID NO: 6.

Some of the genes of the invention are "F-name genes". F-name genes include the genes listed in Table 1, which have 'F' before the RXA, RXN, RXS or RXC name. For example, as shown in Table 1, SEQ ID NO: 11 designated "F RXA02581" is an F-name gene, and SEQ ID NOs: 31, 33, and 43 ("F RXA02487", "F RXA02490" and "F in Table 1, respectively). The same applies to RXA02809 ".

In one embodiment, the nucleic acid molecules of the invention do not include those described in Table 2. For the dapD gene, the sequence for this gene is described in Wehrmann, A., et al, (1998) J. Bacteriol. 180 (12): 3159-3165. However, the sequences obtained by the inventors are considerably longer than the published sequence forms. The published sequence form is dependent on inaccurate start codons and therefore is believed to represent only a fragment of the actual coding region.

In another preferred embodiment, the isolated nucleic acid molecules of the invention comprise nucleic acid molecules that are complements of one of the nucleotide sequences of the invention (eg, sequences of odd sequence numbers in the sequence listing). Nucleic acid molecules complementary to one of the nucleotide sequences shown in the present invention are sufficiently complementary to one of the nucleotide sequences shown in the sequence listing (e.g., an odd sequence number) so that one of the nucleotide sequences of the present invention Hybridization with to form a stable double chain.

In another preferred embodiment, the isolated nucleic acid molecules of the invention comprise about 50%, 51%, 52%, 53% of the nucleotide sequences of the invention (eg, one of the sequences of odd sequence numbers in the sequence listing). , 54%, 55%, 56%, 57%, 58%, 59% or 60% or more, preferably about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68% , 69%, or 70% or more, more preferably about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, or 80%, 81%, 82% , 83%, 84%, 85%, 86%, 87%, 88%, 89%, or 90%, or 91%, 92%, 93%, 94% or more, even more preferably about 95%, 96 Nucleotide sequences having at least%, 97%, 98%, or 99% homology, or portions thereof. Moderate ranges and identity values (eg, 70-90% identical or 80-95% identical) for the aforementioned ranges are included in the present invention. For example, the range of identity values using any combination of the above mentioned upper and / or lower limits is included in the present invention. In a further preferred embodiment, the isolated nucleic acid molecules of the invention comprise nucleotide sequences that hybridize with one or a portion of the nucleotide sequences of the invention, for example under stringent conditions.

In addition, the nucleic acid molecules of the invention encode only a portion of the coding region of one of the sequences of odd sequence numbers in the sequence listing, for example, a biologically active portion of a fragment or MCT protein that can be used as a probe or primer. May include fragments. Nucleotide sequences determined from the cloning of MCT genes from Corynebacterium glutamicum are used to identify MCT homologues from other Corynebacteria or related species as well as from MCT homologues in other types of cells and organisms; ) Probes and primers designed for use in cloning can be generated. Probes / primers typically comprise substantially purified oligonucleotides. Oligonucleotides are typically, under stringent conditions, the sense strand of one of the nucleotide sequences of the invention (eg, one of the sequences of odd sequence numbers in the sequence listing), the anti-sense sequence of one of these sequences, or naturally occurring Nucleotide sequence regions that hybridize with about 12, preferably about 25, more preferably about 40, 50 or 75 or more consecutive nucleotides of the variants thereof. Primers based on the nucleotide sequences of the invention can be used in PCR reactions to clone MCT homologues. Probes based on MCT nucleotide sequences can be used to find transcript or genomic sequences encoding proteins that are identical or homologous. In a preferred embodiment, the probe further comprises a label group attached thereto, for example, the label group can be a radioisotope, fluorescent compound, enzyme or enzyme cofactor. Such probes may be used to detect cells that misexpress an MCT protein, for example by measuring MCT-encoding nucleic acid levels in a cell sample, for example by detecting MCT mRNA levels or determining whether genomic MCT genes have been mutated or deleted. It can be used as part of a diagnostic test kit for identification.

In one embodiment, a nucleic acid molecule of the invention encodes a protein or portion thereof comprising an amino acid sequence that is sufficiently homologous to an amino acid sequence of the invention (eg, an even sequence number in the sequence listing), and The protein or part thereof maintains the ability to participate in the metabolism of compounds necessary for the construction of the cell membrane or the transport of molecules through the membrane in Corynebacterium glutamicum. As used herein, the term “sufficient homologous” means the same or equivalent minimum number of amino acid residues (eg, one amino acid residue in one of the even numbered sequences in the sequence listing) to the amino acid sequence of the present invention. Protein or a portion thereof, the metabolism of a compound required for the construction of a cell membrane in Corynebacterium glutamicum or a molecule through the membrane. May be involved in the transport of Metabolic pathways of such membrane components or protein members of the membrane delivery system may act in the production and secretion of one or more fine chemicals, as described herein. Examples of such activities are also described herein. Thus, "function of MCT protein" contributes directly or indirectly to the yield, production and / or production efficiency of one or more fine chemicals. Examples of MCT protein activity are listed in Table 1.

In another embodiment, the protein is about 50% to 60% or more, preferably about 60% to 70% or more, and more preferably, the entire amino acid sequence of the invention (eg, the sequence of even sequence numbers in the sequence listing) Preferably at least about 70% to 80%, 80% to 90%, 90% to 95%, most preferably at least about 96%, 97%, 98% or 99% homology.

Some of the proteins encoded by the MCT nucleic acid molecules of the invention are preferably biologically active portions of one of the MCT proteins. As used herein, the term “biologically active portion of the MCT protein” is involved in the metabolism of compounds required for the construction of a cell membrane in Corynebacterium glutamicum or the transport of molecules through this membrane or as described in Table 1 A portion of an MCT protein having activity as such, eg, domains / motifs thereof. To determine whether the MCT protein or a biologically active portion thereof may be involved in the metabolism of compounds required for the construction of the cell membrane in Corynebacterium glutamicum or the transport of molecules through the membrane, an analysis of enzymatic activity may be performed. Can be. Such assay methods are well known to those skilled in the art, as described in Example 8.

Other nucleic acid fragments that encode a biologically active portion of an MCT protein may comprise an amino acid sequence of the invention (eg, by a recombinant expression in vitro) that expresses a coding portion of an MCT protein or peptide (eg, by recombinant expression in vitro). A portion of one of the even sequence numbers) can be isolated and evaluated by assessing the activity of the encoded portion of the MCT protein or peptide.

The present invention relates to an MCT protein which differs from one of the nucleotide sequences shown in the present invention (e.g., the sequence of the odd sequence number in the sequence listing) but is identical to the one encoded by the nucleotide sequence of the present invention due to the degeneracy of the genetic code. Nucleic acid molecules (and fragments thereof) that encode. In another embodiment, an isolated nucleic acid molecule of the invention has a nucleotide sequence encoding a protein having an amino acid sequence shown in the sequence listing (eg, an even sequence number). In another embodiment, the nucleic acid molecules of the invention are full-length Corynebacterium glutamicum that are substantially homologous to the amino acid sequences of the invention (encoded by the open reading frame shown in the sequence of odd sequence numbers in the sequence listing). Code the protein.

Those skilled in the art will appreciate that in one embodiment the sequences of the present invention do not comprise prior art sequences such as the Genbank sequences described in Table 2 or 4, which were previously available for the present invention. In one embodiment, the invention is characterized by its identity to a nucleotide or amino acid sequence of the invention that is greater than the sequences of the prior art (e.g., the Genbank sequence described in Tables 2 or 4 (or proteins encoded by such sequences)). Nucleotide sequence and amino acid sequence). For example, the present invention is larger (or greater) than the nucleotide sequence named RXA01420 (SEQ ID NO: 7) and greater than (or greater than) the nucleotide sequence named RXA00104 (SEQ ID NO: 5). Or) a nucleotide sequence having at least 43% identity therewith and a nucleotide sequence that is larger (or larger) than at least 45% identity with the nucleotide sequence named RXA02173 (SEQ ID NO: 25). Those skilled in the art will examine the GAP-calculated percent identity shown in Table 4 for each of the three highest hits for a given sequence, and subtract 100 from the GAP-calculated highest percent identity in any of the inventions. The lower threshold of percent identity for a given sequence may be calculated. Those skilled in the art will also appreciate the percent identity greater than this calculated lower threshold (eg, about 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%). Or at least 60%, preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70%, more preferably about 71%, 72 %, 73%, 74%, 75%, 76%, 77%, 78%, 79%, or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88% , 89%, or 90%, or 91%, 92%, 93%, 94% or more, even more preferably about 95%, 96%, 97%, 98%, or 99% identity) And amino acid sequences are included in the present invention.

Those skilled in the art will appreciate that in addition to the Corynebacterium glutamicum MCT nucleotide sequences described by odd sequence numbers in the sequence listing, polymorphisms in the DNA sequence that result in changes in the amino acid sequence of the MCT protein are present in the population (eg, Corynebacterium glue). Will be present in the Tamicum population). This genetic polymorphism in the MCT gene may exist between individuals in the population due to natural changes. As used herein, the terms "gene" and "recombinant gene" refer to a nucleic acid molecule comprising an open reading frame encoding an MCT protein, preferably Corynebacterium glutamicum MCT protein. Such natural changes typically alter the nucleotide sequence of the MCT gene by 1-5%. Any and all such nucleotide changes of the MCT gene and the resulting polymorphisms of the MCT gene that result from natural changes and do not alter the functional activity of the MCT protein are within the scope of the present invention.

Natural variants and nucleic acid molecules corresponding to the non-Corynebacterium glutamicum homologues of the Corynebacterium glutamicum MCT DNA of the present invention include Based on homology, it can be isolated using Corynebacterium glutamicum DNA or portions thereof as hybridization probes under stringent hybridization conditions according to standard hybridization techniques. Thus, in another embodiment, an isolated nucleic acid molecule of the invention hybridizes with a nucleic acid molecule that is at least 15 nucleotides in length and comprises nucleotide sequences of odd sequence numbers in the sequence listing under stringent conditions. In other embodiments, the nucleic acid is at least 30, 50, 100, or 250 nucleotides in length. As used herein, the term “hybridizing under strict conditions” is meant to describe conditions for hybridization and washing, in which nucleotide sequences that are typically at least 60% homologous to each other remain hybridized with each other. Preferably, these conditions are those under which sequences that are typically at least about 65%, more preferably at least about 70% and even more preferably at least about 75% homologous to each other remain hybridized to each other. Such stringent conditions are well known to those skilled in the art and described in Current Protocols in Molecular Biology, John Wiley & Sons, N.Y. (1989), 6.3.1-6.3.6. A preferred non-limiting example for stringent hybridization conditions is one or more washes in 0.2 × SSC, 0.1% SDS at 50-65 ° C. after hybridization in 6 × sodium chloride / sodium citrate (SSC) at about 45 ° C. Preferably, the isolated nucleic acid molecules of the present invention that hybridize with the nucleotide sequences of the present invention under stringent conditions correspond to naturally occurring nucleic acid molecules. As used herein, “naturally occurring” nucleic acid molecule refers to an RNA or DNA molecule having a nucleotide sequence that exists in nature (eg, encodes a natural protein). In one embodiment, the nucleic acid encodes a native Corynebacterium glutamicum MCT protein.

In addition to naturally occurring variants of the MCT sequences that may be present in the population, those skilled in the art will also appreciate that variations in the nucleotide sequences of the present invention may result in changes in the amino acid sequence of the encoded MCT protein without altering the functionality of the MCT protein. It will be appreciated that it can be introduced. For example, nucleotide substitutions that result in amino acid substitutions at “non-essential” amino acid residues can occur in the nucleotide sequences of the invention. "Non-essential amino acid" residues are residues that can be changed from the wild-type sequence of one of the MCT proteins (eg, the sequence of even sequence numbers in the sequence listing) without changing the activity of said MCT protein. Residues are required for MCT protein activity. However, other amino acid residues (eg, residues that are not conserved or semiconserved in a domain having MCT activity) may not be necessary for activity and therefore can be changed without altering MCT activity.

Accordingly, another aspect of the invention relates to nucleic acid molecules encoding MCT proteins that include changes in amino acid residues that are not essential for MCT activity. Such MCT proteins differ in amino acid sequence from sequences of even sequence numbers in the sequence listing and retain at least one of the MCT activities described herein. In one embodiment, an isolated nucleic acid molecule comprises an amino acid sequence that is at least about 50% homologous to an amino acid sequence of the present invention and is a metabolism of a compound required for the construction of a cell membrane in Corynebacterium glutamicum or a molecule through this membrane. Or nucleotide sequences encoding proteins that may be involved in the transport of or have one or more activities as described in Table 1. Preferably, the protein encoded by the nucleic acid molecule is at least about 50-60% of the amino acid sequence of one of the sequences of odd sequence numbers in the sequence listing, more preferably at least about 60-70% of one of these sequences And even more preferably about 70-80%, 80-90%, 90-95% or more for one of these sequences, most preferably about 96%, 97%, 98 for one of the amino acid sequences of the invention There is homology over% or 99%.

In order to determine the homology (%) of two amino acid sequences (e.g., one of the amino acid sequences of the invention and variant forms thereof) or two nucleic acid sequences, the sequences are aligned (for example, Gaps may be introduced into the sequence of one protein or nucleic acid for optimal alignment with another protein or nucleic acid). Subsequently, amino acid residues or nucleotides corresponding to amino acid positions or nucleotide positions are compared. If a position in one sequence (eg one of the amino acid sequences of the invention) is occupied by the same amino acid residue or nucleotide as the corresponding position in another sequence (eg a variant form of an amino acid sequence), the molecule is Homologous at the position (ie, as used herein, "homology" of an amino acid or nucleic acid is equivalent to "identity" of the amino acid or nucleic acid). The% homology between two sequences is a function of the number of identical positions shared by the sequences (ie,% homology = number of identical positions / total number of positions × 100).

By introducing a substitution, addition or deletion of one or more nucleotides into a nucleotide sequence of the invention such that a substitution, addition or deletion of one or more amino acids is introduced into the protein to be encoded, the protein sequences of the invention (eg, even sequences in the sequence listing) An isolated nucleic acid molecule can be generated that encodes an MCT protein that is homologous to the sequence of number). Mutations can be introduced into one of the nucleotide sequences of the invention by standard techniques such as site-directed mutagenesis and PCR-mediated mutagenesis. Preferably, conserved amino acid substitutions can be made at one or more non-essential amino acid residues contemplated. "Conserved amino acid substitutions" refer to replacement of amino acid residues with amino acid residues having similar side chains. Groups of amino acid residues with similar side chains are defined in the art. These groups include amino acids with basic side chains (eg lysine, arginine, histidine), amino acids with acidic side chains (eg aspartic acid, glutamic acid), amino acids with uncharged polar side chains (eg glycine, Asparagine, glutamine, serine, threonine, tyrosine, cysteine), amino acids with nonpolar side chains (e.g. alanine, valine, leucine, isoleucine, proline, phenylalanine, methionine, tryptophan), amino acids with beta-branched side chains (Eg threonine, valine, isoleucine) and amino acids with aromatic side chains (eg tyrosine, phenylalanine, tryptophan, histidine). Thus, the non-essential amino acid residues expected in the MCT protein are preferably substituted with other amino acid residues from the same side chain group. Alternatively, in another embodiment, the mutations can be introduced randomly along all or part of the MCT coding sequence, eg, by saturation mutagenesis, to identify variants that retain MCT activity. Variants can be screened for MCT activity described herein. One nucleotide sequence of the odd sequence numbered sequences in the sequence listing can then be mutagenesis and then recombinantly expressed the encoded protein, eg, the activity of the protein can be determined using the assays described herein (execution). See example 8.)

  In addition to the nucleic acid molecules encoding the MCT proteins described above, another aspect of the invention relates to an isolated nucleic acid molecule that is antisense thereto. An “antisense” nucleic acid includes a nucleotide sequence that is complementary to a “sense” nucleic acid encoding a protein, eg, complementary to the coding strand of a double-stranded cDNA molecule or complementary to an mRNA sequence. Thus, antisense nucleic acids can hydrogen bond with sense nucleic acids. Antisense nucleic acids may be complementary to the entire MCT coding strand or only a portion thereof. In one embodiment, the antisense nucleic acid molecule is antisense relative to the “coding region” of the coding strand of the nucleotide sequence encoding the MCT protein. The term “coding region” means a region of nucleotide sequence comprising a codon that is translated into an amino acid residue (eg, the entire coding region of SEQ ID NO: 5 (RXA00104) includes nucleotides 1 to 756). In another embodiment, the antisense nucleic acid molecule is antisense relative to the "non-coding region" of the coding strand of the nucleotide sequence encoding the MCT. The term "non-coding region" refers to 5 'and 3' sequences (i.e., also referred to as 5 'and 3' untranslated regions) on either side of a coding region that are not translated into amino acids.

Based on the coding strand sequence encoding the MCT disclosed herein (e.g., this sequence is described by an odd sequence number in the sequence listing), the invention is subject to the base pairing rules of Watson and Crick. Antisense nucleic acids of can be designed. This antisense nucleic acid molecule may be complementary to the entire coding region of the MCT mRNA, but more preferably is an oligonucleotide that is antisense only in a portion of the coding or non-coding region of the MCT mRNA. For example, antisense oligonucleotides may be complementary to the region around the translation initiation site of the MCT mRNA. Antisense oligonucleotides are, for example, about 5, 10, 15, 20, 25, 30, 35, 40, 45 or 50 nucleotides in length. Antisense nucleic acids of the present invention can be constructed using chemical synthesis and enzymatic ligation reactions using methods known in the art. For example, using naturally occurring nucleotides or various modified nucleotides designed to increase the biological stability of the molecule or to increase the physical stability of the double chain formed between antisense and sense nucleic acid (e.g., Phosphorothioate derivatives and acridine substituted nucleotides may be used), antisense nucleic acids (eg, antisense oligonucleotides) may be chemically synthesized. Examples of modified nucleotides that can be used to generate antisense nucleic acids include 5-fluorouracil, 5-bromouracil, 5-chlorouracil, 5-iodouracil, hypoxanthine, xanthine, 4-acetylcytosine, 5- (Carboxyhydroxylmethyl) uracil, 5-carboxymethylaminomethyl-2-thiouridine, 5-carboxymethylaminomethyluracil, dihydrouracil, beta-D-galactosylquaoxin, inosine, N6-isopentenyladenin , 1-methylguanine, 1-methylinosine, 2,2-dimethylguanine, 2-methyladenine, 2-methylguanine, 3-methylcytosine, 5-methylcytosine, N6-adenine, 7-methylguanine, 5-methyl Aminomethyluracil, 5-methoxyaminomethyl-2-thiouracil, beta-D-mannosylquaosine, 5'-methoxycarboxymethyluracil, 5-methoxyuracil, 2-methylthio-N6-isopentenyl Adenine, uracil-5-oxyacetic acid (v), bibutoxosocin, pseudouracil, quaosine, 2-thiocytosine, 5-methyl-2-thiouracil, 2-thiouracil, 4-thiouracil, 5-methyluracil, uracil-5-oxyacetic acid, methyl ester, uracil-5-oxyacetic acid (v), 5-methyl-2-thiouracil, 3- (3-amino -3-N-2-carboxypropyl) uracil, (acp3) w and 2,6-diaminopurine. Alternatively, an antisense nucleic acid can be prepared using an expression vector in which the nucleic acid is subcloned in the antisense direction (ie, RNA transcribed from the inserted nucleic acid is in the antisense direction relative to the target nucleic acid of interest, as further described in the subsection below). Can be produced biologically.

Antisense nucleic acid molecules of the invention are typically administered to cells or by hybridizing to or binding to mRNA and / or genomic DNA of cells that encode MCT proteins, for example by inhibiting transcription and / or translation. And is produced in the reaction system to inhibit the expression of the protein. Hybridization may be by conventional nucleotide complementarity to form a stable double chain, or may be due to, for example, in the case of antisense nucleic acid molecules that bind to a DNA double strand via specific interactions in a double groove major groove. . An antisense molecule can be modified to specifically bind to a receptor or antigen expressed on a selected cell surface, for example by linking the antisense nucleic acid molecule to a peptide or antibody that binds to a receptor or antigen on the cell surface. The vectors described herein may also be used to deliver antisense nucleic acid molecules to cells. In order to achieve sufficient intracellular concentrations of antisense molecules, vector constructs in which the antisense nucleic acid molecules are under the control of strong prokaryotic, viral or eukaryotic promoters are preferred.

In another embodiment, the antisense nucleic acid molecule of the invention is an α-anomeric nucleic acid molecule. α-anomeric nucleic acid molecules form specific double-stranded hybrids with complementary RNAs, where, in contrast to conventional β-units, the strands are parallel to each other (Gaultier et al. (1987)). Nucleic Acids.Res. 15: 6625-6641). Antisense nucleic acid molecules include 2'-o-methylribonucleotides (Inoue et al. (1987) Nucleic Acids Res. 15: 6131-6148) or chimeric RNA-DNA analogs (Inoue et al. (1987) FEBS Lett. 215: 327 -330).

In another embodiment, the antisense nucleic acid molecule of the invention is a ribozyme. Ribozymes are catalytic RNA molecules with ribonuclease activity and are capable of cleaving single stranded nucleic acids such as mRNA having complementary regions thereto. Thus, using a ribozyme (e.g., Hammerhead ribozyme (as described in Haselhoff and Gerlach (1988) Nature 334: 585-591)), the MCT mRNA transcript is catalyzed. The cleavage of MCT mRNA can be suppressed by cleavage. Based on the nucleotide sequence of the MCT DNA disclosed herein (ie, SEQ ID NO: 5 (RXA00104)), one can design a ribozyme with specificity for the MCT-encoding nucleic acid. For example, derivatives of Tetrahymena L-19 IVS RNA can be made wherein the nucleotide sequence of the active site is complementary to the nucleotide sequence cleaved from the MCT-encoding mRNA [eg, Cech. US Pat. No. 4,987,071, et al. And US Pat. No. 5,116,742 to Cech et al. Alternatively, MCT mRNA can be used to screen catalytic RNA with specific ribonuclease activity from pools of RNA molecules. See, eg, Bartel, D. and Szostak, JW (1993) Science 261: 1411. -1418].

Alternatively, expression of the MCT gene by targeting a nucleotide sequence complementary to the regulatory region (eg, MCT promoter and / or enhancer) of the MCT nucleotide sequence to form a triple helix structure that prevents transcription of the MCT gene in the target cell. Can be suppressed [Generally, Helene, C. (1991) Anticancer Drug Des. 6 (6): 569-84; Helene, C. et al. (1992) Ann.N.Y. Acad. Sci. 660: 27-36; and Maher, L.J. (1992) Bioassays 14 (12): 807-15].

B. Recombinant Expression Vectors and Host Cells

Another aspect of the invention relates to an expression vector containing a nucleic acid encoding a vector, preferably an MCT protein (or a portion thereof). As used herein, the term “vector” refers to a nucleic acid capable of transporting other nucleic acids linked thereto. As a type of vector, "plasmid" refers to a circular double stranded DNA ring into which additional DNA segments can be ligated. Another type of vector, a viral vector, can ligate additional DNA segments into the viral genome. Certain vectors can be autonomously replicated in introduced host cells (eg, bacterial vectors with bacterial origin of replication and episomal vectors in mammals). Other vectors (eg, mammalian non-episomal vectors) are introduced into the host cell and then integrated into the host genome to replicate together along the host genome. In addition, certain vectors may direct the expression of genes to which they are operatively linked. Such vectors are referred to herein as "expression vectors." In general, expression vectors used in recombinant DNA techniques are usually in the form of plasmids. Since plasmids are the most commonly used vector form, "plasmid" and "vector" can be used interchangeably herein. However, the present invention also encompasses other forms of expression vectors such as viral vectors that provide equivalent functions (eg, replication defective retroviruses, adenoviruses and adeno-associated viruses).                 

The recombinant expression vector of the present invention comprises the nucleic acid of the present invention in a form suitable for expression of the nucleic acid in a host cell, and the suitable form means that the recombinant expression vector is one or more regulatory sequences selected based on the host cell for expression (the nucleic acid to be expressed). Operably linked to a sequence). Within a recombinant expression vector, “operably linked” means that the regulatory sequence (eg, in an in vitro transcription / translation system or in the host cell when the vector is introduced into the host cell) is expressible such that S). The term "regulatory sequence" is intended to include promoters, enhancers and other expression control elements (eg, polyadenylation signals). Such regulatory sequences are described, for example, in Goeddel; Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, CA (1990). Regulatory sequences include constitutive expression of nucleotide sequences within multiple host cell types and expression of nucleotide sequences only within specific host cells. Preferred regulatory sequences include, for example, cos-, tac-, trp-, tet-, trp-tet-, lpp-, lac-, lpp-lac-, lacI ^q- , T7-, T5 which are preferably used in bacteria. -Promoters such as T3-, gal-, trc-, ara-, SP6-, arny, SPO2, λ-P _R -or λP _L. Further regulatory sequences include, for example, promoters from yeast and fungi such as ADC1, MFα, AC, P-60, CYC1, GAPDH, TEF, rp28, ADH, CaMV / 35S, SSU, OCS, lib4, usp, STLS1 , Promoters from plants such as B33, nos or ubiquitin- or cessolin-promoter. Artificial promoters can also be used. Those skilled in the art will appreciate that the expression vector may be designed differently depending on factors such as the choice of host cell to be transformed, the degree of expression of the protein of interest, and the like. Expression vectors of the invention may be introduced into a host cell to produce a protein or peptide, including fusion proteins or peptides encoded by the nucleic acids described herein (eg, MCT proteins, mutant forms of MCT proteins, fusion proteins, etc.). Can be.

Recombinant expression vectors of the invention can be designed for MCT protein expression in prokaryotic or eukaryotic cells. For example, the MCT gene may be a bacterial cell such as Corynebacterium glutamicum, insect cells (using baculovirus expression vectors), yeast and other fungal cells (Romanos, MA et al . (1992) "Foreign gene expression in yeast: a review ", Yeast 8: 423-488; van den Hondel, CAMJJ et al . (1991)" Heterologous gene expression in filamentous fungi "in: More Gene Manipulations in Fungi, JW Bennet & LL Lasure, eds. , p. 396-428: Academic Press: San Diego; and van den Hondel, CAMJJ & Punt, PJ (1991) "Gene transfer systems and vector development for filamentous fungi, in: Applied Molecular Genetics of Fungi, Peberdy, JF et al , eds., p. 1-28, Cambridge University Press: Cambridge), algae and multicellular plant cells (Schmidt, R. and Willmitzer, L. (1988) High efficiency Agrobacterium tumefactiens -mediated transformation of Arabidopsis thaliana 583-586 in reference) or mammalian cells: leaf and cotyledon explants "Plant cell Rep. It can be expressed. Suitable host cells are further described in Goeddel, Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, CA (1990). Alternatively, recombinant expression vectors can be transcribed and translated in vitro using, for example, a T7 promoter regulatory sequence and a T7 polymerase.

Protein expression in prokaryotic cells is usually performed with constitutive or inducible promoter containing vectors that direct the expression of fusion or non-fusion proteins. Fusion vectors add a plurality of amino acids to their encoded protein, usually at the C-terminus as well as at the amino terminus of the recombinant protein, or fuse the plurality of amino acids within the appropriate region of the protein. Such fusion vectors are typically for three purposes: 1) to increase expression of the recombinant protein, 2) to increase the solubility of the recombinant protein, and 3) to facilitate the purification of the recombinant protein by acting as a ligand in affinity purification. Usually, in the fusion expression vector, a protein cleavage site is introduced at the junction of the fusion moiety and the recombinant protein so that the recombinant protein can be separated from the fusion moiety after purification of the fusion protein. Such enzymes and their cognate recognition sequences include coagulation factors Xa, thrombin and enterokinase, and the like.

Typical fusion expression vectors include pGEX (Pharmacia Biotech Inc; see Smith, DB and Johnson, KS (1988) Gene 67: 31-40), pMAL (New England Biolabs, Beverly, Mass.) And pRIT5 (Pharmacia, Piscataway, NJ) and the like, each of which fuses glutathione-S-transferase (GST), maltose E binding protein or protein A (protein A) to the target recombinant protein. In one embodiment, the coding sequence of the MCT protein was cloned into a pGEX expression vector to generate a fusion protein coding vector containing a GST-thrombin cleavage site-X protein at the N-terminus to C-terminus. The fusion protein can be purified by affinity chromatography using glutathione-agarose resin. Recombinant MCT proteins that are not fused to GST can be obtained by cleaving the fusion protein with thrombin.

Examples of suitable inducible non-fusion E. coli expression vectors include pTrc (see Amann et al ., (1988) Gene 69: 301-315), pLG338, pACYC184, pBR322, pUC18, pUC19, pKC30, pRep4, pHS1, pHS2, pPLc236, pMBL24, pLG200, pUR290, pINIII113-B1, λgt11, pBdCl and pET 11d (Studier et al ., Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, California (1990) 60-89 And Pouwels et al ., Eds. (1985) Cloning Vectors.Elsevier: New York IBSN 0 444 904018). Target genes in pTrc vectors are expressed by the transcription of host RNA polymerase from a trp-lac hybrid fusion promoter. In the pET 11d vector the target gene is expressed by transcription mediated by viral RNA polymerase (T7 gn1) co-expressed from the T7 gn 10-lac fusion promoter. This viral polymerase is supplied from a lambda propage containing the T7 gn1 gene under the transcriptional control of the lacUV 5 promoter, which is present in host strain BL21 (DE3) or HMS174 (DE3). Suitable vectors can be selected for the transformation of various bacteria. For example, plasmids pIJ101, pIJ364, pIJ702 and pIJ361 are known to be useful for transforming Streptomyces , while plasmids pUB110, pC194 or pBD214 are suitable for transforming Bacillus species. Plasmids used to transfer genetic information into Corynebacterium include pHM1519, pBL1, pSA77 or pAJ667 (see Pouwels et al ., Eds. (1985) Cloning Vectors. Elsevier: New York IBSN 0 444 904018). have.

One strategy for maximizing the expression of recombinant proteins is to express them in host bacteria that have impaired proteolytic cleavage of the recombinant proteins (Gottesman, S., Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, California (1990) 119-128). Another strategy is to modify the nucleic acid sequence of the nucleic acid to be inserted into the expression vector so that individual codons for each amino acid are selected by the bacteria selected for expression (e.g., Corynebacterium glutamicum glutamicum). (See Wada et al . (1992) Nucleic Acids Res . 20: 2111-2118). As such, modification of the nucleic acid sequences of the present invention can be carried out by standard DNA synthesis techniques.

In other embodiments, the MCT protein expression vector is a yeast expression vector. Examples of expression vectors of yeast Saccharomyces cerevisiae include pYepSec1 (Baldari, et al ., (1987) Embo J.6: 229-234), 2μ, pAG-1, Yep6, Yep13 , pEMBLYe23, pMFa (see Kurjan and Herskowitz, (1982) Cell 30: 933-943), pJRY88 (see Schultz et al ., (1987) Gene 54: 113-123) and pYES2 (Invitrogen Corporation) , San Diego, CA). Suitable vectors and methods of making them for other fungi, such as filamentous fungi, are described by van den Hondel, CAMJJ & Punt, PJ (1991) "Gene transfer systems and vector development for filamentous fungi, in: Applied Molecular Genetics of Fungi, JF Peberdy, et al ., Eds., P. 1-28, Cambridge University Press: Cambridge and Pouwels et al ., Eds. (1985) Cloning Vectors.Elsevier: New York (IBSN 0 444 904018). Those mentioned above are included.

Alternatively, baculovirus expression vectors can be used to express the MCT protein of the invention in insect cells. Baculovirus vectors for protein expression in cultured insect cells (eg, Sf 9 cells) include pAc systems (see Smith et al . (1983) Mol. Cell Biol . 3: 2156-2165) and pVL (Lucklow and Summers (1989) Virology 170: 31-39).

In other embodiments, the MCT protein of the invention can be expressed in plant cells from single cell plant cells (eg algae) or higher plants (eg seed plants such as crop plants). Examples of plant expression vectors include Becker, D., Kemper, E., Schell, J. and Masterson, R. (1992) "New plant binary vectors with selectable markers located proximal to the left border", Plant Mol. Biol . 20: 1195-1197, Bevan, MW (1984) “Binary Agrobacterium vectors for plant transformation”, Nucl. Acid. Res . 12: 8711-8721, including those described above and including pLGV23, pGHlac +, pBIN19, pAK2004 and pDH51 (see Pouwels et al ., Eds. (1985) Cloning Vectors. Elsevier: New York IBSN 0 444 904018). do.

In another embodiment, a mammalian expression vector is used to express the nucleic acid of the invention in a mammalian cell. Examples of mammalian expression vectors include pCDM8 (see Seed, B. (1987) Nature 329: 840) and pMT2PC (see Kaufman et al . (1987) EMBO J. 6: 187-195). . When using mammalian cells, the regulatory function of the expression vector is usually by viral regulatory elements. For example, commonly used promoters are derived from polyoma, adenovirus 2, cytomegalovirus and simian virus 40. Other expression systems suitable for both prokaryotic and eukaryotic cells can be found in Chapters 16 and 17 of Sambrook, J., Fritsh, EF, and Maniatis, T. Molecular Cloning: A Laboratory Manual. 2nd. ed. Cold Spring Harbor Laboratory , Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989.

In other embodiments, recombinant mammalian expression vectors allow for differential nucleic acid expression in certain cell types (eg, tissue-specific regulatory elements are used to express nucleic acids). Tissue-specific regulatory elements are known in the art. Examples of suitable tissue-specific promoters include albumin promoter (liver-specific; see Pinkert et al . (1987) Genes Dev . 1: 268-277), lymphoid-specific promoters (Calame and Eaton). (1988) Adv. Immunol . 43: 235-275), in particular promoters of T cell receptors (see Winoto and Baltimore (1989) EMBO J. 8: 729-733) and promoters of immunoglobulins (see [ Banerji et al . (1983) Cell 33: 729-740, see Queen and Baltimore (1983) Cell 33: 741-748), neuron-specific promoters (eg neurofilament promoters; Byrne) and Ruddle (1989) PNAS 86: 5473-5477), pancreas-specific promoters (see Edlund et al . (1985) Science 230: 912-916) and mammary gland-specific promoters (eg For example, whey promoter; see US Pat. No. 4,873,316 and European Application No. 264,166, and the like. In addition, developmental-regulatory promoters such as the murine hox promoter (see Kessel and Gruss (1990) Science 249: 374-379) and the α-fetoprotein promoter (Campes and Tilghman (1989) Genes Dev . 3 : 537-546).

The present invention further provides a recombinant expression vector containing a DNA molecule of the invention cloned in an expression vector in an antisense direction. That is, the DNA molecule is operably linked to regulatory sequences to enable expression (by transcription of the DNA molecule) of an RNA molecule that is antisense to MCT mRNA. Regulatory sequences operably linked to the nucleic acid cloned in the antisense direction can be chosen to allow for continuous expression of antisense RNA molecules in various cell types, such as, for example, viral promoters and / or enhancers, or the antisense RNA is constitutive. Regulatory sequences may also be selected that allow for tissue-specific or cell type specific expression. Antisense expression vectors can be in the form of recombinant plasmids, phagemids or attenuated viruses that produce antisense nucleic acids under the control of highly efficient regulatory regions, the activity of which can be determined by the cell type into which the vector has been introduced. For controlling gene expression using antisense genes, see Weintraub, H. et al ., Antisense RNA as a molecular tool for genetic analysis, Reviews - Trends in Genetics , Vol. 1 (1) 1986).

Another aspect of the invention relates to a host cell into which the recombinant expression vector of the invention has been introduced. The terms "host cell" and "recombinant host cell" are used interchangeably herein. Such terms are understood not only to refer to specific subject cells but also to progeny or potential progeny of such cells. In fact, such progeny are not identical to parental cells, but may still fall within the scope of the term used herein, as any modification may occur due to mutations or environmental effects over generations.

The host cell can be any prokaryotic or eukaryotic cell. For example, MCT proteins can be expressed in bacterial cells such as Corynebacterium glutamicum, insect cells, yeast or mammalian cells (eg, Chinese hamster ovary cells (CHO) or COS cells). Other suitable host cells are known to those skilled in the art. Corynebacterium glutamicum related microorganisms that can be readily used as host cells for the nucleic acid and protein molecules of the present invention are described in Table 3.

Vector DNA can be introduced into prokaryotic or eukaryotic cells via conventional transformation or transfection techniques. As used herein, the terms “transformation” and “transfection”, “conjugation” and “transduction” refer to heterologous nucleic acids (eg, linear DNA or RNA (eg, linear genes, or single genes without vectors). Structures)) or various known techniques for introducing nucleic acids in the form of vectors (e.g., plasmids, phages, phosphides, phagemids, transposons or other DNA) into host cells, including calcium phosphate or calcium chloride. Co-precipitation, DEAE-dextran-mediated transfection, lipofection, natural competence, chemical mediated delivery, or electroporation. Suitable methods for transforming or transfecting host cells are described in Sambrook et al . ( Molecular Cloning: A Laboratory Manual. 2nd, ed., Cold Spring Harbor Laboratory , Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989) and other experimental manuals.

For stable transfection of mammalian cells, it is known that only a few minor cells incorporate foreign DNA into their genome, depending on the expression vector and the transfection technique used. To identify and select these integrations, genes encoding generally selectable labels (eg, antibiotic resistance) are introduced into the host cell along with the gene of interest. Preferred selectable labels include those that confer drug resistance, such as G418, hygromycin and methotrexate. The nucleic acid encoding the selectable label can be introduced into a host cell on the vector encoding the MCT protein, or can be introduced on a separate vector. Cells stably transfected with the introduced nucleic acid can be identified through drug selection (eg, cells incorporating selectable label genes will survive, but other cells will die).

To prepare a homologous recombinant microorganism, a vector containing at least a portion of the MCT gene that has been modified (eg, disrupted in function) by making a deletion, addition or substitution is introduced. Preferably this MCT gene is a Corynebacterium glutamicum MCT gene, but may be a homologue from mammal, yeast or insect origin as well as homologues from related bacteria. In a preferred embodiment, the vector is designed such that by homologous recombination the endogenous MCT gene is functionally disrupted (ie, no longer encodes a functional protein, also referred to as a "knock-out" vector). Alternatively, the vector is designed to encode a functional protein (ie, upstream regulatory regions can be modified so that expression of the endogenous MCT protein can be modified) by homologous recombination where the endogenous MCT gene has been mutated or otherwise modified. In homologous recombination vectors, additional nucleic acids of the MCT gene are located on the 5 'and 3' sides of a portion of the altered MCT gene so that homologous recombination occurs between the exogenous MCT gene carried by the vector and the endogenous MCT gene in the microorganism. The added flanking MCT nucleic acid is of sufficient length to successfully homologous recombination with the endogenous gene. Typically, several kilobases of flanking DNA (both 5 'and 3' ends) are included in the vector (eg, Thomas, KR, and Capecchi, MR (1987), which describe homologous recombination vectors. ) Cell 51: 503). The vector is introduced into the microorganism (eg, by electroporation), and the cells in which the introduced MCT gene and the endogenous MCT gene are homologous recombination are selected by known techniques.

In other embodiments, recombinant microorganisms containing a system selected to be capable of controlling the expression of the introduced gene can be prepared. For example, if the vector contains an MCT gene regulated by lac operon, the MCT gene can be expressed only in the presence of IPTG. Such control systems are known in the art.

In other embodiments, the endogenous MCT gene in the host cell is disrupted (eg, by homologous recombination or other genetic means known in the art) such that its protein product is not expressed. In other embodiments, the introduced MCT gene or endogenous MCT gene in the host cell is altered by one or more point mutations, deletions or inversions, but still encodes a functional MCT protein. In other embodiments, one or more regulatory regions (eg, promoters, inhibitors or inducers) in the microorganism are altered (eg, by deletions, truncation, inversion or point mutations) to alter the expression of the MCT protein. . Those skilled in the art will appreciate that host cells containing one or more of the MCT gene and protein modifications described above can be readily generated using the methods of the invention and are included in the invention.

Host cells of the invention, such as prokaryotic or eukaryotic host cells in culture, are used for the production (ie expression) of MCT proteins. Accordingly, the present invention further provides a method for producing MCT protein using the host cell of the present invention. In one embodiment, the method comprises the steps of introducing a host cell of the invention (recombinant expression vector encoding an MCT protein or a gene encoding a wild type or modified MCT protein introduced into the genome) until the MCT protein is produced. Culturing in a suitable medium. In other embodiments, the method further comprises isolating MCT protein from said medium or host cell.

C. Isolated MCT Protein

Another aspect of the invention relates to an isolated MCT protein and its biologically active site. An "isolated" or "purified" protein or biologically active site thereof is substantially free of cellular material when produced by recombinant DNA technology, or substantially free of chemical precursors or other chemicals when chemically synthesized. The term “substantially free of cellular material” includes an MCT protein preparation that isolates the protein from the cellular components of cells that produce MCT proteins, either naturally or by recombination. In one embodiment, the term "substantially free of cellular matter" means that the non-MCT protein (also referred to herein as "pollutant protein") content is less than about 30% (dry weight), preferably less than about 20%, More preferably less than about 10%, most preferably about 5%. In addition, when the MCT protein or its biologically active site is produced recombinantly, it is preferred that the culture medium is substantially free. That is, protein preparations that exhibit a culture medium content of less than about 20% by volume, more preferably less than about 10% by volume and most preferably less than 5% by volume are preferred. The term “substantially free of chemical precursors or other chemicals” includes MCT protein preparations that separate the protein from chemical precursors or other chemicals involved in the synthesis of the MCT protein. In one embodiment, the term “substantially free of chemical precursors or other chemicals” means that the content of the chemical precursor or non-MCT chemical is less than about 30% (dry weight), preferably less than about 20%, more preferably. Preferably less than about 10%, most preferably about 5%. In a preferred embodiment, the isolated protein or biologically active site thereof is free of contaminating protein from the organism from which the MCT protein is derived. Typically, such proteins are produced by recombinant expression of Corynebacterium glutamicum MCT protein in microorganisms such as, for example, Corynebacterium glutamicum.                 

Isolated MCT proteins or portions thereof of the present invention may be involved in the metabolism of compounds required for the construction of cell membranes in Corynebacterium glutamicum or the transport of molecules through these membranes, or may have one or more of the activities listed in Table 1 Can be. In a preferred embodiment, the protein or fragment thereof comprises an amino acid sequence that is sufficiently homologous to the amino acid sequence of the present invention (e.g., an even numbered sequence number in the sequence listing) and the composition of the cell membrane in Corynebacterium glutamicum. Maintain the ability to participate in the metabolism of necessary compounds or the transport of molecules through this membrane. Some of these proteins are preferably biologically active sites as described herein. In another preferred embodiment, an MCT protein of the invention has an amino acid sequence described in a sequence having an even sequence number in the sequence listing. In another preferred embodiment, the MCT protein is an amino acid sequence encoded by a nucleotide sequence that hybridizes (eg, hybridizes under stringent conditions) to a nucleotide sequence of the invention (e.g., an sequence having an odd sequence number in the sequence listing). Has In another preferred embodiment, the MCT protein has about 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, homology with one of the nucleic acid sequences of the invention or a portion thereof, 58%, 59% or 60% or more, preferably about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69% or 70% or more, more preferably about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79% or 80% or more, 81%, 82%, 83%, 84%, 85%, 86%, 87 %, 88%, 89% or 90% or more, 91%, 92%, 93%, 94% or more, more preferably about 95%, 96%, 97%, 98%, 99% or more Has an amino acid sequence encoded by the sequence. In addition, intermediate ranges and identity values (eg, 70-90% identical or 80-95% identical) for the aforementioned ranges are included in the present invention. For example, the range of identity values using any combination of the above mentioned upper and / or lower limits is included in the present invention. In addition, preferred MCT proteins of the present invention preferably possess one or more MCT activities described herein. For example, preferred MCT proteins of the present invention include amino acid sequences encoded by nucleotide sequences that hybridize (eg, hybridize under stringent conditions) to the nucleotide sequences of the present invention and constitute a cell membrane in Corynebacterium glutamicum. May be involved in the metabolism of compounds required for the transport or transport of molecules through this membrane, or may have one or more of the activities listed in Table 1.

In another embodiment, the MCT protein is substantially homologous to an amino acid sequence of the invention (e.g., an sequence with an even sequence number in the sequence listing), and the amino acid sequence is altered due to natural variation or mutation as described above in column I. Otherwise retains the functional activity of a protein of one of the amino acid sequences of the invention. Thus, in another embodiment, the MCT protein has about 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59 homology with the entire amino acid sequence of the present invention. % Or 60% or more, preferably about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69% or 70% or more, more preferably about 71%, 72 %, 73%, 74%, 75%, 76%, 77%, 78%, 79% or 80% or more, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88% , At least 89% or 90%, or at least 91%, 92%, 93%, 94%, and more preferably about 95%, 96%, 97%, 98%, 99% or more. , One or more of the MCT activities described herein. In addition, intermediate ranges and identity values (eg, 70-90% identical or 80-95% identical) for the aforementioned ranges are included in the present invention. For example, the range of identity values using any combination of the above mentioned upper and / or lower limits is included in the present invention. In another embodiment, the present invention relates to a full length Corynebacterium glutamicum protein that is substantially homologous to the entire amino acid sequence of the present invention.

A biologically active site of an MCT protein includes an amino acid sequence derived from an amino acid sequence of an MCT protein (eg, an sequence numbered evenly in the sequence listing) or includes an amino acid sequence of a protein homologous to an MCT protein and is a full length MCT protein or MCT. It is homologous to the protein and contains fewer amino acids than the full-length protein exhibiting at least one MCT protein activity. Typically, a biologically active site (peptides, eg, peptides having amino acid lengths of 5, 10, 15, 20, 30, 35, 36, 37, 38, 39, 40, 50, 100 or more) may be present in the MCT protein. Domains or motifs having one or more activities. In addition, other regions of the protein may be deleted such that other biologically active sites can be prepared by recombinant techniques and measure one or more of the activities described herein. Preferably, the biologically active site of the MCT protein comprises one or more selected domains / motifs or portions thereof having biological activity.

MCT proteins are preferably produced by recombinant DNA technology. For example, the nucleic acid molecule encoding the protein is cloned into an expression vector (as described above), the expression vector is introduced into a host cell (as described above), and the MCT protein is introduced into the host cell. Expressed in. The MCT protein can then be isolated from the cells through appropriate purification steps using standard protein purification techniques. Apart from recombinant expression, MCT proteins, polypeptides or peptides can be chemically synthesized using standard peptide synthesis techniques. In addition, native MCT proteins can be isolated from cells (eg, endothelial cells) using, for example, anti-MCT antibodies that can be produced by standard methods using the MCT proteins of the invention or portions thereof.

The present invention also provides an MCT chimeric or fusion protein. As used herein, MCT “chimeric protein” or “fusion protein” includes MCT polypeptides operably linked to non-MCT polypeptides. "MCT polypeptide" refers to a polypeptide having an amino acid sequence corresponding to an MCT, and a "non-MCT polypeptide" refers to a protein that is substantially homologous to an MCT protein, eg, that is derived from an organism that is different from the MCT protein and that is different from the MCT protein. A polypeptide having an amino acid sequence corresponding to a protein. In fusion proteins, the term “operably linked” means that the MCT polypeptide and the non-MCT polypeptide are fused to each other in frame. The non-MCT polypeptide may be fused to the N-terminus or C-terminus of the MCT polypeptide. For example, in one embodiment, the fusion protein is a GST-MCT fusion protein in which the MCT sequence is fused to the C-terminus of the GST sequence. Such fusion proteins can facilitate the purification of recombinant MCT proteins. In another embodiment, the fusion protein is an MCT protein containing a heterologous signal sequence at its N-terminus. In certain host cells (eg, mammalian host cells), expression and / or secretion of MCT proteins can be increased by using heterologous signal sequences.

Preferably, the MCT chimeric or fusion proteins of the invention are produced by standard recombinant DNA techniques. For example, DNA fragments encoding separate polypeptide sequences can be used in accordance with conventional techniques, for example using blunt-ended or staggered ends for ligation, with restriction enzymes to make appropriate ends. The ligation is cut, optionally filled with adhesive ends, and ligated together in the same frame by treatment with alkaline phosphatase to avoid undesirable linkage and ligation with enzymes. In other embodiments, the fusion gene can be synthesized by conventional techniques using automated DNA synthesizers and the like. Alternatively, the anchor fragments can be PCR amplified using anchor primers that produce complementary overhangs between two consecutive gene fragments, which are subsequently annealed and reamplified to generate chimeric gene sequences (eg, See Current Protocols in Molecular Biology, eds. Ausubel et al . John Wiley & Sons: 1992). In addition, many expression vectors that already encode fusion moieties (eg, GST polypeptides) are commercially available. MCT encoding nucleic acids can be cloned into such expression vectors to link the fusion moiety to the MCT protein in the same frame.

Homologues of MCT proteins can be produced by mutagenesis, eg, by fractional point mutations or cleavage of the ends of the MCT protein. As used herein, the term “homolog” refers to a variant form of MCT protein that acts as an agonist or antagonist to the activity of the MCT protein. The biological activity of the MCT protein agonist may be substantially the same as or comparable to that of the MCT protein. Antagonists of MCT proteins are competitively bound to, for example, downstream or upstream members of the cascade of cell membrane component metabolism, including MCT proteins, or by binding to MCT proteins that regulate the transport of compounds through the membrane to prevent translocation MCT proteins can inhibit one or more active forms of naturally occurring forms.

In other embodiments, homologs of the MCT protein can be identified by screening combinatorial libraries of MCT protein mutants (eg, terminal truncation mutants) for MCT protein agonist or antagonist activity. In one embodiment, the mixed library of MCT variants is generated by combinatorial mutagenesis at the nucleic acid level and encoded by the mixed gene library. A mixed library of MCT variants enzymatically ligates a synthetic oligonucleotide mixture to a gene sequence, for example, to allow a degenerate set of potential MCT sequences to be expressed as individual polypeptides or, alternatively, to a set of MCT sequences therein. Can be expressed as a large fusion protein (eg, phage display). Various methods can be used to produce a library of potential MCT homologues from multivalent oligonucleotide sequences. An automated DNA synthesizer can be used to chemically synthesize the multigenic gene sequence, which can then be ligated into an appropriate expression vector. Genetic diversity sets can be used to provide all sequences encoding a desired set of possible MCT sequences in one mixture. Methods of synthesizing multivalent oligonucleotides are known in the art (eg, Narang, SA (1983) Tetrahedron 39: 3, Itakura et al . (1984) Annu. Rev. Biochem. 53: 323, Itakura et al . (1983) Science 198: 1056, Ike et al . (1983) Nucleic Acid Res. 11: 477.

In addition, fragment libraries of MCT protein coding genes can be used to generate a mixed population of MCT fragments for screening and subsequent selection of MCT protein homologues. In one embodiment, the nuclease is treated to a double stranded PCR fragment of the MCT coding sequence, the double stranded DNA is denatured, and the DNA is denatured under conditions in which nicking occurs only about once per molecule. ) To form double stranded DNA which may include sense / antisense pairs from other notch products, and treatment with S1 nuclease to remove the single stranded portion from the reformed double strands and express the resulting fragment library. Libraries of coding sequence fragments can be prepared by ligation into vectors. By this method, expression libraries encoding the N-terminus, C-terminus and internal fragments of MCT proteins of various sizes can be derived.

Several techniques are known in the art for screening gene products of combinatorial libraries made by point mutations or truncation and cDNA library screening for gene products having selected properties. Such techniques can be used to quickly screen gene libraries generated by combinatorial mutagenesis of MCT homologues. As the most widely used technique, techniques available in high throughput assays for screening large gene libraries typically include cloning the gene library into replicable expression vectors, transforming the appropriate cells with the generated vector library, and Detection of activity includes expressing a combination gene under conditions that facilitate the isolation of the vector encoding the gene product to be detected. Recursive ensemble mutagenesis (REM), a new technique for increasing the frequency of functional mutations in libraries, can be used in conjunction with screening assays to identify MCT homologues (Arkin and Yourvan (1992) PNAS 89: 7811-7815, Dellgrave et al . (1993) Protein Engineering 6 (3): 327-331).

In another embodiment, altered MCT libraries can be analyzed using cell line assays using methods known in the art.

D. Uses and Methods of the Invention

Nucleic acid molecules, proteins, protein homologues, fusion proteins, primers, vectors and host cells described herein can be used to identify corynebacterium glutamicum and related organisms, genomic mapping of organisms associated with corynebacterium glutamicum, Identification and location of target sequences of Corynebacterium glutamicum, evolutionary studies, determination of MCT protein sites required for function, regulation of MCT protein activity, regulation of metabolism of one or more cell membrane components, transmembrane of one or more compounds It may be used in one or more of methods such as the control of transport, and the control of cell production of the target compound, such as fine chemicals.

MCT nucleic acid molecules of the present invention have a variety of uses. First, it can be used to confirm the presence of Corynebacterium glutamicum or its close homologues. It can also be used to confirm the presence of Corynebacterium glutamicum or its close homologues in mixed microbial populations. The present invention is directed to a large number of cory that can confirm the presence of such organisms by probing genomic DNA extracted from single or mixed microbial cultures using probes spanning gene regions unique to Corynebacterium glutamicum under stringent conditions. Nucleic acid sequences of the Nebacterium glutamicum gene are provided.

Corynebacterium glutamicum itself is not pathogenic, but is associated with Corynebacterium diphtheriae. Corynebacterium diphtheria is the causative agent of diphtheria, a rapidly developing acute fever infection with local and systemic lesions. In these diseases, local lesions develop on the upper respiratory tract, accompanied by necrotic damage to epithelial cells, and Bacillus secretes toxins, which spread through the lesion to tissues susceptible to infection. Degenerative changes caused by inhibition of protein synthesis in such tissues, including the heart, muscle peripheral nerves, adrenal glands, kidneys, liver and spleen, cause systemic pathology of the disease. Diphtheria has a high incidence in many parts of the world, including Africa, Asia, Eastern Europe and the independent states of the former Soviet Union. The epidemic diphtheria, which continues in eastern Europe and the Soviet Union's independent states, has caused more than 5,000 deaths since 1990.

In one embodiment, the present invention provides a method for identifying the presence or activity of Corynebacterium diphtheria in a subject. The present invention includes detecting the presence or activity of Corynebacterium diphtheria in a subject by detecting one or more nucleic acid or amino acid sequences of the invention (represented by odd or even sequence numbers in the sequence listing, respectively) in the subject. Corynebacterium glutamicum and Corynebacterium diphtheria are related bacteria, and many of the nucleic acid and protein molecules of Corynebacterium glutamicum are homologous to the nucleic acid and protein molecules of Corynebacterium diphtheria. It can be used to detect Corynebacterium diphtheria in.

In addition, nucleic acid and protein molecules of the invention function as markers of specific regions of the genome. This function is useful not only for genome mapping but also for the study of the function of Corynebacterium glutamicum protein. For example, the Corynebacterium glutamicum genome can be cut to incubate fragments with DNA binding proteins to identify genomic regions to which specific DNA binding proteins of Corynebacterium glutamicum bind. The region that binds to the protein can also be probed with a nucleic acid molecule of the invention, preferably a label that can be easily detected. The binding of nucleic acid molecules to such genomic fragments allows the fragments to be located on the genomic map of Corynebacterium glutamicum and, if performed multiple times with different enzymes, quickly and easily determines the nucleic acid sequences to which the proteins bind. . In addition, the nucleic acid molecules of the present invention may have sufficient homology with the sequences of the associated species and can be used as markers for creating genomic maps of associated bacteria such as Brevibacterium lactofermentum.

In addition, the MCT nucleic acid molecules of the present invention are useful for evolution and protein structure studies. Metabolic and energy free processes involving the molecules of the invention are utilized by a wide variety of prokaryotic and eukaryotic bacteria. The evolutionary association of an organism can be assessed by comparing the sequences of nucleic acid molecule sequences of the present invention with nucleic acid molecule sequences encoding enzymes similar to other organisms. Similarly, such comparisons can assess whether a sequence region is conserved, which can help determine protein regions essential for enzyme function. This method of determination is useful for protein engineering and can indicate whether it can tolerate induced mutations without loss of protein function.

By manipulation of the MCT nucleic acid molecule of the present invention, an MCT protein having a function different from that of a wild type MCT protein can be produced. Such proteins may be improved in efficiency or activity, may be present in excess than normal cells, or may be reduced in efficiency or activity.

The present invention provides a method for screening molecules that modulate the activity of an MCT protein by interacting with the protein itself or with a substrate or binding partner of the MCT protein or by regulating the transcription or translation of the MCT nucleic acid molecule of the invention. In this method, an organism expressing at least one MCT protein of the invention is contacted with at least one test compound to assess the effect of each test compound on the activity or expression level of the MCT protein.

There are several mechanisms that can directly affect the yield, production and / or production efficiency of fine chemicals from the Corynebacterium glutamicum strain comprising the modified protein by the modification of the MCT protein of the present invention. . The recovery of fine chemical compounds from large-scale cultivation of Corynebacterium glutamicum is significantly enhanced when Corynebacterium glutamicum secretes the desired compounds, which is derived from the culture medium (Corynebacterium glutamicum). Because it can be easily purified) as opposed to extracting from a population of Qum cells. By increasing the number or activity of carrier molecules that excrete fine chemicals from cells, the amount of produced fine chemicals present in the extracellular medium can be increased and thus more easily harvested and purified. Conversely, to effectively overproduce one or more fine chemicals, it is necessary to increase the amount of cofactors, precursor molecules, and intermediate compounds for the proper biosynthetic pathway. Thus, by increasing the number and / or activity of carrier proteins involved in the influx of nutrients such as carbon sources (i.e. sugars), nitrogen sources (i.e. amino acids, ammonium salts), phosphates, and sulfur, By eliminating restrictions on nutrient supply, it is possible to increase the production of fine chemicals. In addition, fatty acids and lipids may be obtained by optimizing or increasing the number of one or more MCT proteins of the invention involved in the biosynthesis of such compounds, or by reducing the activity of one or more MCT proteins involved in the degradation of such compounds. It is, by itself, a preferred fine chemical and can increase the yield, production and / or production efficiency of fatty acid and lipid molecules from Corynebacterium glutamicum.

Manipulation of one or more MCT genes of the present invention may produce MCT proteins with modified activity that indirectly affect the production of one or more desired fine chemicals from Corynebacterium glutamicum. For example, normal biochemical metabolic processes produce a variety of waste products (eg, hydrogen peroxide and other reactive oxygen species) that can actively interfere with this same metabolic process (eg, peroxynitrite is tyrosine It is known to inactivate some enzymes with tyrosine in the active site by nitrifying the side chain (Groves, JT (1999) Curr. Opin. Chem. Biol. 3 (2): 226-235). These waste products are commonly discharged, and Corynebacterium glutamicum strains used for large-scale fermentation production are those commonly produced in wild-type Corynebacterium glutamicum by optimizing for overproduction of one or more fine chemicals. More waste products can be produced. By optimizing the activity of one or more MCT molecules of the invention involved in the excretion of waste product molecules, it is possible to improve the viability of cells and maintain effective metabolic activity. In addition, the target fine chemicals present at high levels in the cells may actually be toxic to the cells, thereby improving cell viability by increasing the activity of the cells secreting these compounds.

In addition, the MCT proteins of the invention can be engineered to produce appropriate amounts of various lipid and fatty acid molecules. This can have a significant effect on the lipid composition of the cell membrane. Since each lipid type can have different physical properties, changes in membrane lipid composition can significantly change the fluidity of the membrane. Changes in membrane fluidity can affect the transport of molecules through the membrane, which can change the outflow of waste products or the resulting fine chemicals or the influx of essential nutrients, as described above. Such changes in membrane fluidity may have a significant impact on cell integrity, and cells with relatively weak membranes become more lethal for mechanical stresses that can damage or kill cells in large fermentor environments. Higher proportions of Corynebacterium glues are produced by manipulating MCT proteins involved in the production of fatty acids and lipids for membrane construction so that the resulting membranes are more suitable for the environmental conditions present in the cultures used to produce the fine chemicals. Tamicum survives and multiplies. Larger numbers of Corynebacterium glutamicum in culture significantly increase the yield, production or production efficiency of fine chemicals from the culture.

The above-mentioned mutagenesis methods for the MCT protein to increase the yield of fine chemicals from Corynebacterium glutamicum are not limited, and variations of such methods will be apparent to those skilled in the art. Use of such methods, including the mechanisms disclosed herein, and the use of the nucleic acids and protein molecules of the present invention to produce Corynebacterium glutamicum or related strains expressing mutated MCT nucleic acids and protein molecules, yielding the desired compounds. To improve production and / or production efficiency. The compound of interest is a coryne including a molecule produced by the Corynebacterium glutamicum strain, which does not inherently occur in Corynebacterium glutamicum metabolism, as well as intermediates of the biosynthetic pathway and intermediates of natural metabolic pathways. It can be any product produced by bacterium glutamicum.

In addition, the present invention is illustrated by the following examples, but should not be construed as being limited thereto. All references, patent applications, patents, all contents of published patent applications, tables and sequences listed herein are incorporated by reference.                 

Example 1 Prep of Whole Genome DNA of Corynebacterium glutamicum ATCC 13032

Corynebacterium glutamicum (ATCC 13032) cultures in BHI medium (Difco) were grown overnight with vigorous shaking at 30 ° C. Cells were harvested by centrifugation to discard the supernatant and cells were resuspended in 5 ml Buffer-I (corresponding to 5% of the initial volume of culture—all volumes indicated for 100 ml of culture volume). The composition of Buffer-I was as follows: 140.34 g / L sucrose, 2.46 g / L MgS0 ₄ × 7 H ₂ O, 10 ml / L KH ₂ PO ₄ solution (100 g / L, pH 6.7 using KOH) ), 50 ml / L M12 concentrate (10 g / L (NH ₄ ) ₂ SO ₄ , 1 g / L NaCl, 2 g / L MgSO ₄ × 7 H ₂ O, 0.2 g / L CaCl ₂ , 0.5 g / L yeast extract (from Difco), 10 ml / L trace element mixture (200 mg / L FeSO ₄ × H ₂ O, 10 mg / L ZnSO ₄ × 7 H ₂ O, 3 mg / L MnCl ₂ × 4 H ₂ O, 30 mg / LH ₃ BO ₃ , 20 mg / L CoCl ₂ × 6 H ₂ O, 1 mg / L NiCl ₂ × 6 H ₂ O, 3 mg / L Na ₂ MoO ₄ × 2 H ₂ O, 500 mg / L complexing agent (EDTA or citric acid), 100 ml / L vitamin mixture (0.2 mg / L biotin, 0.2 mg / L folic acid, 20 mg / L p-amino benzoic acid, 20 mg / L riboflavin, 40 mg / L ca Pantothenate, 140 mg / L nicotinic acid, 40 mg / L pyridoxol hydrochloride, 200 mg / L myo-inositol) To the suspension lysozyme was added at a final concentration of 2.5 mg / ml, approximately 4 hours at 37 ° C. During incubation, then breaking the cell wall and centrifuging The protoplasts were harvested The pellet was washed once with 5 ml Buffer-I and washed once with 5 ml TE-buffer (10 mM Tris-HCl, 1 mM EDTA, pH 8). Resuspend in buffer and add 0.5 ml SDS solution (10%) and 0.5 ml NaCl solution (5 M) Proteinase K was added to a final concentration of 200 μg / ml, and then the suspension was 37 ° C. The DNA was purified by extraction with phenol, phenol-chloroform-isoamyl alcohol and chloroform-isoamyl alcohol using standard methods, followed by 1/50 volume of 3 M sodium acetate and DNA was precipitated by the addition of 2 volumes of ethanol, then incubated at -20 ° C for 30 minutes and centrifuged at 12,000 rpm for 30 minutes with a high speed centrifuge using SS34 rotor (Sorvall). The DNA was dissolved in 1 ml TE-buffer containing 20 μg / ml RNaseA and dialyzed in 1000 ml TE-buffer at 4 ° C. for at least 3 hours. During dialysis, the buffer was changed three times. 0.4 ml aliquots of the dialyzed DNA solution were added, and 0.4 ml 2 M LiCl and 0.8 ml ethanol were added. DNA was collected by incubation at −20 ° C. for 30 minutes and then centrifuged (13,000 rpm, Biofuge Fresco, Hanau Heraeus, Germany). DNA pellets were dissolved in TE-buffer. DNA prepared in this manner was used for all purposes, such as Southern blotting or genome library construction.

Example 2: Genome Library Construction of Corynebacterium glutamicum ATCC13032 in Escherichia Coli

Using prepared DNA as described in Example 1, known and established methods (eg, Sambrook, J. et al. (1989) "Molecular Cloning: A Laboratory Manual", Cold Spring Harbor Laboratory) Presses or see Ausubel, FM et al. (1994) "Current Protocols in Molecular Biology", John Wiley & Sons) to produce cosmid and plasmid libraries.

Any plasmid or cosmid could be used. In particular, plasmid pBR322 (Sutcliffe, J.G. (1979) Proc. Natl. Acad. Sci. USA, 75: 3737-3741); pACYC177 (Change & Cohen (1978) J. Bacteriol 134: 1141-1156), plasmids of the pBS family (pBSSK +, pBSSK-, etc .; Stratagene, LaJolla, USA), or SuperCos I (Stratagene, LaJolla, USA) or Lorist 6 (Gibson, TJ, Rosenthal A. and Waterson, RH (1987) Gene 53: 283-286). Specifically, the gene library for use in Corynebacterium glutamicum is plasmid pSL 109 (Lee, H.-S. and AJ Sinskey (1994) J. Microbiol. Biotechnol. 4: 256-263). Can be produced using.

Example 3: DNA sequencing and functional analysis using a computer

Using a genomic library as described in Example 2, DNA sequencing according to standard methods, in particular chain termination methods using ABI377 sequencers (see, eg, Fleischman, RD et al. (1995) "Whole- DNA sequencing was performed by genome Random Sequencing and Assembly of Haemophilus Influenzae Rd., Science, 269: 496-512.Sequencing primers with the following nucleotide sequences were used: 5'-GGAAACAGTATGACCATG-3 ' 677) or 5'-GTAAAACGACGGCCAGT-3 '(SEQ ID NO: 678).

Example 4: In vivo Mutagenesis

In vivo mutagenesis of Corynebacterium glutamicum has been shown to enhance the ability of E. coli or other microorganisms (eg, Bacillus spp. ) Or Saccharomyces cerevisiae to compromise their ability to maintain complete genetic information . Yeast) such as plasmid (or other vector) DNA can be performed by passage. Typical mutagenesis strains include genes related to DNA repair systems (eg mutHLS, mutD, mutT, etc .; for reference, see Rupp, WD (1996) DNA repair mechanisms, in: Escherichia coli and Salmonella , p. 2277- 2294, ASM: Washington). Such strains are known to those skilled in the art. The use of such strains is described, for example, in Greener, A. and Callahan, M. (1994) Strategies 7: 32-34.

Example 5: DNA transfer between E. coli and Corynebacterium glutamicum

Several Corynebacterium and Brevibacterium species contain endogenous plasmids that autonomously replicate (eg, pHM1519 or pBL1, etc.) (see, for example, Martin, JF et al. (1987) Biotechnology, 5: 137-146). Shuttle vectors for use with E. coli and Corynebacterium glutamicum are standard vectors used for E. coli, with the origin of replication for Corynebacterium glutamicum and the appropriate markers from Corynebacterium glutamicum Sambrook, J. et al. (1989), "Molecular Cloning: A Laboratory Manual", Cold Spring Harbor Laboratory Press, or Ausubel, FM et al. (1994) "Current Protocols in Molecular Biology", John Wiley & Sons]). The origin of replication is preferably obtained from endogenous plasmids isolated from Corynebacterium and Brevibacterium species. In particular, genes used as transformation markers for these species may be kanamycin resistance genes (eg, derived from Tn5 or Tn903 transposon, etc.) or chloramphenicol resistance genes (Winnacker, EL (1987) "From Genes to Clones-Introduction". to Gene Technology, VCH, Weinheim]) There are numerous documents on the construction of a wide variety of shuttle vectors that can be cloned in both E. coli and Corynebacterium glutamicum and used for a variety of purposes including gene overexpression. (For reference, see, eg, Yoshihama, M. et al. (1985) J. Bacteriol. 162: 591-597, Martin JF et al. (1987) Biotechnology, 5: 137-146) and See Eikmanns, BJ et al. (1991) Gene, 102: 93-98).

Using standard methods, the gene of interest can be cloned into one of the shuttle vectors described above and this hybrid vector can be introduced into the Corynebacterium glutamicum strain. Transformation of Corynebacterium glutamicum is known as protoplast transformation (Kastsumata, R. et al. (1984) J. Bacteriol. 159: 306-311), electroporation (Liebl, E. et al. (1989) FEMS Microbiol.Letters, 53: 399-303) and conjugation methods when certain vectors are used (eg, Schaefer, A et al. (1990) J. Bacteriol. 172: 1663). -1666). In addition, prep the plasmid DNA from Corynebacterium glutamicum (using standard methods known in the art) and transform it into Escherichia coli to transfer the shuttle vector to E. coli for use in Corynebacterium glutamicum. It may be. This transformation step can be performed using standard methods, but using a Mcr-deficient Escherichia coli strain such as NM522 (Gough & Murray (1983) J. Mol. Biol. 166: 1-19) and the like. It is advantageous.

pCGl (US Pat. No. 4,617,267) or fragments thereof, and optionally kanamycin resistance genes from TN903 (Grindley, ND and Joyce, CM (1980) Proc. Natl. Acad. Sci. USA 77 (12 ): 7176-7180]) can be used to overexpress genes in Corynebacterium glutamicum strains. In addition, overexpressing genes in Corynebacterium glutamicum strains using plasmid pSL 109 (Lee, H.-S. and AJSinskey (1994) J. Microbiol. Biotechnol. 4: 256-263). You can.

In addition to using a replicative plasmid, gene overexpression may also be achieved by integration into the genome. Genomic integration in Corynebacterium glutamicum or other Corynebacterium or Brevibacterium species is characterized by homologous recombination with genomic region (s), restriction endonuclease mediated integration (REMI) (eg, literature (See German Patent No. 19823834), or by known methods such as using transposon. In addition, regulatory regions (e.g., by deletion, insertion, or deletion of sequences using positioning methods (e.g., homologous recombination) or random event based methods (e.g., transposon mutagenesis or REMI) For example, promoters, inhibitors, and / or enhancers) may be modified to modulate the activity of the gene of interest. In addition, a nucleic acid sequence that functions as a transcription terminator may be inserted into one or more coding regions 3 'of a gene of the present invention; Such terminators are known in the art and are described, for example, in Winnacker, E.L. (1987) From Genes to Clones-Introduction to Gene Technology. VCH: Weinheim.

Example 6: Expression Evaluation of Mutant Proteins

Observation of the activity of the mutated protein in the transformed host cell revealed that the mutant protein was expressed in a similar manner and in a similar amount to the wild type protein. Useful methods for determining the level of transcription of a mutant gene (an indicator of the amount of mRNA available for translation into a gene product) include Northern blotting (see, for example, Ausubel et al. (1988) Current Protocols in Molecular). Biology, Wiley: New York), which extracts the whole RNA of a biological culture, develops it on a gel, transfers it to a stable matrix, and then binds to the gene of interest to detect a tag (usually Incubating with a primer labeled with a radioactive or chemiluminescent tag), the binding of the probe and its binding amount also indicate the presence and amount of mRNA of the gene of interest. This information is evidence of the degree of transcription of the mutant gene. Intracellular total RNA of Corynebacterium glutamicum is described, for example, in Bormann, E.R. et al. (1992) Mol. Microbiol. 6: 317-326 can be prepared using a variety of methods known in the art.

To assess the presence or relative amount of a protein translated from this mRNA, standard techniques such as western blotting can be used (see, for example, Ausubel et al. (1988) Current Protocols in Molecular Biology, Wiley). New York). In this method, the whole protein in the cell is extracted, separated by gel electrophoresis, and then transferred to a matrix such as nitrocellulose and incubated with a probe such as an antibody that specifically binds to a desired protein. Typically, these probes are tagged with chemiluminescent or colorimetric labels that can be easily detected. The presence and amount of the label observed indicates the presence and amount of the desired mutant protein in the cell.

Example 7: Growth-Medium and Culture Conditions of Genetically Modified Corynebacterium glutamicum

Genetically modified corynebacteria are cultured in synthetic or natural growth media. Numerous different growth media of Corynebacteria are known in the art and are also readily available (Lieb et al. (1989) Appl. Microbiol. Biotechnol., 32: 205-210, von der Osten (1998) Biotechnology Letters, 11: 11-16, German Patent No. 4,120,867, Liebl (1992) "The Genus Corynebacterium", in: The Procaryotes, Volume II, Balows, A. et. al., eds. Springer-Verlag]. The medium consists of one or more carbon sources, nitrogen sources, inorganic salts, vitamins and trace elements. Preferred carbon sources are sugars such as monosaccharides, disaccharides, or polysaccharides. For example, glucose, fructose, mannose, galactose, ribose, sorbose, ribulose, lactose, maltose, sucrose, raffinose, starch or cellulose serve as very good carbon sources. In addition, the sugar may be supplied to the medium through complex compounds such as molasses or other by-products produced during sugar purification. It may also be advantageous to feed a mixture of different carbon sources. Other possible carbon sources are alcohols and organic acids such as methanol, ethanol, acetic acid or lactic acid. Nitrogen sources are typically organic or inorganic nitrogen compounds, or materials containing such compounds. Examples of nitrogen sources include ammonia gas or ammonia salts such as NH ₄ Cl or (NH ₄ ) ₂ SO ₄ , NH ₄ 0H, nitrates, ureas, amino acids or corn liquor, soy flour, soy protein, yeast extract, Complex nitrogen sources such as meat extracts.

Inorganic salt compounds that may be included in the medium include calcium, magnesium, sodium, cobalt, molybdenum, potassium, manganese, zinc, copper and iron hydrochlorides, phosphates, or sulfates. Chelating compounds can be added to the medium to keep metal ions in solution. Particularly useful chelating compounds include dihydroxyphenols such as catechol or protocatechuate, organic acids such as citric acid, and the like. Also, the medium typically contains other growth factors such as vitamins or growth promoters, examples of which include biotin, riboflavin, thiamine, folic acid, nicotinic acid, pantophenate and pyridoxine. Growth factors and salts often occur in complex media components such as yeast extract, molasses, corn soak and the like. The exact composition of the media compound will vary greatly with subsequent experiments and will be determined separately for each particular case. Information on media optimization can be found in Applied Microbiol. Physiology, A Practical Approach (eds. PM Rhodes, PF Stanbury, IRL Press (1997) pp.53-73, ISBN 0 19 963577 3). It is also possible to select from growth media from the manufacturer, such as Standard 1 (Merck) or BHI (Leads in Grain, DIFCO).

All media components are sterilized by heat treatment (20 minutes at 1.5 bar and 121 ° C.) or sterile filtration. These components can be sterilized all at once or they can be sterilized separately as needed. All media components may be present from the beginning of the culture, or optionally added continuously or batchwise.

Culture conditions are defined separately for each experiment. The temperature should be in the range between 15 ° C and 45 ° C. The temperature can be kept constant or changed during the experiment. The pH of the medium should be in the range of 5 to 8.5, preferably about 7.0, and can be maintained by adding buffer to the medium. Examples of buffers that can be used for this purpose include potassium phosphate buffers and the like. Synthetic buffers such as MOPS, HEPES, ACES, etc. may alternatively or simultaneously be used. It is also possible to keep the pH of the culture constant by adding NaOH or NH ₄ OH during the culture. When complex media components such as yeast extracts are used, many complex compounds have high buffering performance, which may reduce the need for additional buffers. When the fermentor is used for microbial culture, the pH may be controlled using ammonia gas.

Incubation time ranges are typically several hours to several days. This time is chosen so that the amount of product that accumulates in the broth is maximum. The disclosed culture experiments can be performed in a variety of vessels, such as microtiter plates, glass tubes, glass flasks or glass or metal fermenters of different sizes. To screen numerous clones, microorganisms must be cultured in microtiter plates, glass tubes or shake flasks with or without baffles. It is preferable to use the required growth medium by filling 10% (volume ratio) in a 100 ml shake flask. These flasks should be shaken (25 mm amplitude) on a rotary shaker in the speed range 100-300 rpm. The amount of loss due to evaporation can be reduced by keeping the atmosphere wet; Alternatively, the amount of loss due to evaporation must be corrected correctly.

When testing genetically modified clones, unmodified control clones or control clones containing base plasmids without any inserts should also be tested. CM plates incubated at 30 ° C. (10 g / L glucose, 2.5 g / L NaCl, 2 g / L urea, 10 g / L polypeptone, 5 g / L yeast extract, 5 g / L meat extract, 22 g / Cells on agar plates, such as L agar, adjusted to pH 6.8 with 2 M NaOH), and the like are seeded in the medium to an OD ₆₀₀ 0.5-1.5. Medium inoculation is performed by introducing saline suspensions of Corynebacterium glutamicum cells from CM plates or by adding precultures of these bacteria.

Example 8 In Vitro Analysis of the Function of Mutant Proteins

Methods of measuring enzyme activity and reaction rate parameters are well established in the art. Experiments for measuring activity of any given modified enzyme should be tailored to the inactivation of the wild type enzyme and one skilled in the art can do this well. Specific details regarding the structure, reaction rates, principles, methods, and applications of enzymes, as well as a general overview of enzymes and examples of methods for measuring activity of many enzymes, can be found in the following references: Dixon, M. and Webb, EC, (1979) Enzymes. Longmans: London; Fersht, (1985) Enzyme Structure and Mechanism. Freeman: New York, Walsh, (1979) Enzymatic Reaction Mechanisms. Freeman: San Francisco, Prix, NC, Stevens, L. (1982) Fundamentals of Enzymology. Oxford Univ. Press: Oxford, Boyer, PD, ed. (1983) The Enzymes, 3 ^rd ed. Academic Press: New York, Bisswanger, H., (1994) Enzymkinetik, 2 ^nd ed. VCH: Weinheim (ISBN 3527300325), Bergmeyer, HU, Bergmeyer, J., Grassl, M., eds. (1983-1986) Methods of Enzymatic Analysis, 3 rd ed, vol.I-XII, Verlag Chemie:. Weinheim], and the literature [Ullmann's Encyclopedia of Industrial Chemistry ( 1987) vol.A9, "Enzymes". VCH: Weinheim, p.352-363].

Protein activity that binds to DNA can be measured using a variety of well-established methods, such as DNA band-displacement assays (also called gel retardation assays). The effect of these proteins on the expression of other molecules is described in reporter gene analysis (see, eg, Kolmar, H. et al. (1995) EMBO J. 14: 3895-3904) and references cited therein. As shown in FIG. 2). Reporter gene test systems using enzymes such as β-galactosidase, green fluorescent proteins, and many others are known and well established for application to both prokaryotic and eukaryotic cells.

Measurement of the activity of membrane transport proteins is described in Gennis, R.B. (1989) "Pores, Channels and Transporters", in Biomembranes, Molecular Structure and Function, Springer: Heidelberg, p. 85-137, 199-234, and 270-322, and the like.

Example 9: Analysis of the Effect of Mutant Proteins on Desired Product Production

The effect of genetic modification on Corynebacterium glutamicum on the production of the desired compound (e.g., amino acid) may be achieved by culturing the modified microorganism under appropriate conditions (e.g., as described above), Media components and / or intracellular components involved in increased production of product (ie, amino acids) can be assessed by analysis. Such analytical techniques are known to those skilled in the art and include analytical chromatography methods such as spectroscopy, thin layer chromatography, various staining, enzymatic and microbiological methods, and high performance liquid chromatography methods (e.g., literature Ullman, Encyclopedia of Industrial Chemistry, vol. A2, p. 89-90 and p. 443-613, VCH: Weinheim (1985), Falllon, A. et al., (1987) "Applications of HPLC in Biochemistry "in: Laboratory Techniques in Biochemistry and Molecular Biology, vol. 17, Rehm et al. (1993) Biotechnology, vol. 3, Chapter III:" Product recovery and purification ", page 469-714, VCH: Weinheim Belter, PA et al. (1988) Bioseparations: downstream processing for biotechnology, John Wiley and Sons, Kennedy, JF and Cabral, JMS (1992) Recovery processes for biological materials, John Wiley and Sons, Shaeiwitz, JA and Henry, JD (1988) Biochemical separations, in: Ulmann's Ency See clopedia of Industrial Chemistry, vol. B3, Chapter 11, page 1-27, VCH: Weinheim, and Dechow, F.J. (1989) Separation and purification techniques in biotechnology, Noyes Publications).

In addition to the determination of the final fermentation product, it is also possible to analyze other components of the metabolic pathways used to produce the desired compound, such as intermediates and by-products, and to determine the overall compound production efficiency. Analytical methods include measuring the content of nutrients (eg, sugars, hydrocarbons, nitrogen sources, phosphates and other ions) in the medium, determining the composition and growth of biomass, analyzing the production of common metabolites in biosynthetic pathways, and Gas measurements generated during fermentation. Standard methods for such measurements are described in Applied Microbial Physiology, A Practical Approach, PMRhodes and PFStanbury, eds., IRL Press, p. 103-129, 131-163, and 165-192 (ISBN: 0199635773) and References cited in the literature.

Example 10 Purification of Desired Product from Corynebacterium glutamicum Culture

Various methods known in the art can be used to recover the desired product from Corynebacterium glutamicum cells or supernatants of the cultures described above. If the desired product is not secreted from the cells, the cultures can be harvested by low speed centrifugation and the cells can be lysed by standard techniques such as mechanical force or ultrasound. Cell debris is removed by centrifugation and the supernatant portion containing the soluble protein is left for further purification of the desired compound. If the product is secreted from Corynebacterium glutamicum cells, the cultures are centrifuged at low speed to remove the cells, leaving the supernatant portion for further purification.

The supernatant portion by any of the two purification methods is subjected to chromatography using a suitable resin, so that the desired molecule remains on the chromatography resin but no impurities remain in the sample, or the impurities remain in the resin but the desired molecule remains. Does not remain. If desired, these chromatography steps can be repeated using the same or different chromatography resins. Those skilled in the art will be skilled in selecting suitable chromatography resins and applying them most effectively for the purification of particular molecules. The purified product can be concentrated by filtration or ultrafiltration and stored at a temperature where the stability of the product is maximum.

Purification methods known in the art are various and are not limited to the purification methods described above. Such purification techniques are described, for example, in Bailey, J.E. & Ollis, D.F. Biochemical Engineering Fundamentals, McGraw-Hill: New York (1986).

Identification and purity of the isolated compound can be assessed by standard techniques in the art. These include high performance liquid chromatography (HPLC), spectroscopy, staining, thin layer chromatography, NIRS, enzymatic analysis, or microbiological methods. The assay method is reviewed in the following literature: Patek et al. (1994) Appl. Environ. Microbiol. 60: 133-140, Malakhova et al. (1996) Biotekhnologiya 11: 27-32, Schmidt et al. (1998) Bioprocess Engineer. 19: 67-70, Ulmann's Encyclopedia of Industrial Chemistry, (1996) vol. A27, VCH: Weinheim, p. 89-90, p.521-540, p.540547, p.559-566, p. 575-581 and p. 581-587, Michal, G. (1999) Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology, John Wiley and Sons, and Falllon, A. et al. (1987) Applications of HPLC in Biochemistry in: Laboratory Techniques in Biochemistry and Molecular Biology, vol. 17.

Example 11: Gene Sequence Analysis of the Invention

Sequence comparison and determination of percent homology between two sequences is a technique known in the art, which is described by Karlin and Altschul (1990) Proc. Natl. Acad. Sci. USA 87: 2264-68, see Karlin and Altschul (1993) Proc. Natl. Acad. Sci. USA 90: 5873-77 may be used using mathematical algorithms, such as modified ones. The algorithm is described in Altschul, et al. (1990) J. Mol. Biol. 215: 403-10, the NBLAST and XBLAST programs (version 2.0). The nucleotide sequence homologous to the MCT nucleic acid molecule of the present invention can be obtained by searching for BLAST nucleotides with the NBLAST program with score = 100, wordlength = 12. The BLAST protein can be searched by the XBLAST program with score = 50 and wordlength = 3 to obtain an amino acid sequence homologous to the MCT protein molecule of the present invention. Altschul et al., (1997) Nucleic Acids Res. 25 (17): 3389-3402, a gap alignment for comparison can be obtained using gap BLAST. Those skilled in the art will know how to optimize the parameters of a program (eg, XBLAST and NBLAST) for the specific sequence to be analyzed when using the BLAST and Gap BLAST programs.

Other examples of mathematical algorithms used for sequence comparisons include Meyers and Miller (1988) Comput. Appl. Biosci. 4: 11-17]. This algorithm is introduced into the ALIGN program (version 2.0) which is part of the GCG sequence alignment software package. When using the ALIGN program for amino acid sequence comparison, the PAM 120 weight residue table, gap length penalty 12, and gap penalty 4 can be used. Additional sequencing algorithms are known in the art and described in Torelli and Robotti (1994) Comput. Appl. Biosci. 10: 3-5] and ADVANCE and ADAM., And Pearson and Lipman (1988) P.N.A.S. 85: 2444-8.

In addition, the percent homology comparison between the two amino acid sequences was performed using the Blosum 62 matrix or PAM250 matrix, and the gap weight 12, 10, 8, 6, or 4 and the length weight 2, 3, or 4 GCG software package. It may also be performed using the GAP program (available at http://www.gcg.com). The percent homology comparison between two nucleic acid sequences can be performed using the GAP program in the GCG software package with standard parameters such as gap weight 50 and length weight 3.

The gene sequences of the present invention were compared with those of Genbank using techniques known in the art (see, eg, Bexevanis and Ouellette, eds. (1998) Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins.John Wiley and Sons: New York. The gene sequence of the present invention and GenBank's gene sequence were compared by a 3-step method. In the first step, each of the sequences of the present invention was subjected to BLASTN analysis (eg, local alignment analysis) on the nucleotide sequences of Genbank, leaving the top 500 hits for further analysis. A FASTA search was then performed on the 500 hits (eg, combined local and global alignment analysis, aligning a defined region of the sequence). Then, using the GAP program in the GCG software package (using standard parameters), each gene sequence of the invention was globally aligned to each of the top three FASTA hits. To obtain accurate results, the lengths of the sequences selected in Genbank were adjusted to the length of the sequences using methods known in the art. The analysis results are shown in Table 4. The data thus obtained were identical to the data obtained by comparing each gene of the present invention with each of the reference sequences of Genbank by performing GAP (general) analysis alone, but the computer needed when comparing the database-extensive GAP (general) analysis. The usage time was much reduced. Unaligned sequences of the present invention are shown in Table 4 as cutoff values without alignment information. Furthermore, those skilled in the art will, in Table 4, list the GAP alignment homology (%) in European numeric format under the heading "% homology (GAP)", where ',' means decimal point. For example, the value "40,345" in this stage means "40.345%".

Example 12 Preparation and Implementation of DNA Microarrays

Sequences of the invention are well known in the art for DNA microarrays (designs, methods, and uses of DNA arrays, see Schena, M. et al. (1995) Science 270: 467-470, Wodicka, L. et al. (1997) Nature Biotechnology 15: 1359-1367, DeSaizieu, A. et al. (1998) Nature Biotechnology 16: 45-48, and DeRisi, JL et al. (1997) Science 278: 680-686), and the like.

DNA microarrays are solid or flexible supports composed of nitrocellulose, nylon, glass, silicone, or other materials. Nucleic acid molecules can be attached to this surface in a sequential manner. After appropriate labeling, other nucleic acids or nucleic acid mixtures can be hybridized to the immobilized nucleic acid molecules, and the labels can be used to monitor and measure the individual signal strengths of the hybridized molecules in defined regions. Using this method, it is possible to simultaneously quantify the relative or absolute amounts of all or selected nucleic acids in an applied nucleic acid sample or mixture. Therefore, DNA microarrays allow for simultaneous analysis of large (6800 or more) nucleic acid expression (see, eg, Schena, M. (1996) BioEssays 18 (5): 427-431).

The sequence of the present invention can be used for the design of oligonucleotide primers capable of amplifying a limited region of one or more Corynebacterium glutamicum genes by nucleic acid amplification reactions such as polymerase chain reaction. Selection and design of 5 'or 3' oligonucleotide primers or appropriate linkers resulted in PCR products described above (see also, eg, Schena, M. et al. (1995) Science 270: 467-470). It can also be covalently attached to the surface of the support medium.                 

In addition, nucleic acid microarrays are described by Wodicka, L. et al. (1997) Nature Biotechnology 15: 1359-1367, may also be prepared by in situ oligonucleotide synthesis. According to the photolithographic method, a matrix of exactly defined areas is exposed to light. As a result, the unstable protecting group is activated to cause nucleotide addition, but no modification occurs to the light-shielded region. Different oligonucleotides are synthesized at positions defined by subsequent protection and photoactivation cycles. Small confined regions of the genes of the invention can be synthesized by solid oligonucleotide synthesis on microarrays.

Nucleic acid molecules of the invention present in a sample or nucleotide mixture can hybridize with the microarray. Such nucleic acid molecules can be labeled according to standard methods. Briefly, isotopic or fluorescently labeled nucleotides are incorporated, for example, during reverse transcription or during DNA synthesis to label nucleic acid molecules (eg, mRNA molecules or DNA molecules). Methods of hybridizing labeled nucleic acids to microarrays are described in, for example, Schena, M. et al. (1995) supra, Dodicka, L. et al. (1997), supra And DeSaizieu A. et al. (1998), supra. Methods of detecting and quantifying hybridized molecules depend on the specific label incorporated. Radiolabels are described, for example, in Schena, M. et al. (1995) supra, and fluorescent labels can be detected, for example, by Shalon et al. (1996) Genome Research 6: 639-645.

As described above, application of the sequences of the present invention to DNA microarray techniques allows for the comparative analysis of different strains of Corynebacterium glutamicum or other Corynebacteria. For example, the study of variants between strains based on individual transcript profiles and the identification of genes important for specific and / or desired strain characteristics, such as pathogenicity, productivity and stress tolerance, are facilitated by nucleic acid alignment. In addition, nucleic acid alignment techniques can be used to compare the gene expression profiles of the present invention during the fermentation reaction process.

Example 13: Kinetic Analysis of Intracellular Protein Populations (Proteomics)

The genes, compositions, and methods of the present invention can be applied to the interaction and kinetics studies of protein populations, referred to as 'proteomics'. The protein population of interest includes the entire protein population of Corynebacterium glutamicum (eg, as compared to the protein populations of other organisms), specific environmental or metabolic conditions (eg, during fermentation, at high or low temperatures, Or a population of proteins active under high pH or low pH), or a population of proteins active during certain periods of growth and development.

Protein populations can be analyzed by various known techniques, such as gel electrophoresis. Intracellular proteins can be obtained by lysis or extraction and can be separated from one another using a variety of electrophoretic techniques. Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) separates proteins primarily by their molecular weight. Isoelectric focusing Polyacrylamide gel electrophoresis (IEF-PAGE) separates proteins according to their isoelectric point (meaning not only amino acid sequences but also post-translational variants of the protein). Further preferred protein assays are a continuous parallel of both IEF-PAGE and SDS-PAGE, also known as 2D-gel electrophoresis (see, eg, Hermann et al. (1998) Electrophoresis 19: 3217-3221). , Funtoulakis et al. (1998) Electrophoresis 19: 1193-1202, Langen et al. (1997) Electrophoresis 18: 1184-1192, Antelmann et al. (1997) Electrophoresis 18: 1451-1463 ]. Proteins can also be separated using other separation techniques known in the art, such as capillary gel electrophoresis.

Proteins isolated in this way can be visualized by standard techniques such as staining or labeling. Suitable dyes are known in the art and include fluorescent dyes such as Coomassie Brilliant Blue, Silver Dye, or Sypro Ruby (Molecular Probes) and the like. Radiolabeled amino acids or other protein precursors (eg, ³⁵ S-methionine, ³⁵ S-cysteine, ¹⁴ C-labeled amino acids, ¹⁵ N-amino acids, ¹⁵ NO ₃ or ¹⁵ NH ₄ ⁺ or ¹³ C-labeled Amino acids) can be included in Corynebacterium glutamicum medium to label them before separating proteins from the cells. Similarly, fluorescent labels can be used. The labeled proteins can be extracted, isolated and separated according to the techniques described above.

Proteins visualized by this technique can be further analyzed by measuring the amount of dye or label used. The amount of a given protein can be quantitatively determined using optical methods or the like and can be compared with other protein amounts in the same gel or in other gels. Proteins on the gel can be compared through optical comparison, spectroscopy, image scanning and gel analysis, or the use of photographic films and screens. Such techniques are known in the art.

To determine what any given protein is, direct sequencing or other standard techniques can be used. For example, N- and / or C-terminal amino acid sequencing (e.g., Edman digestion) and mass spectroscopy (especially MALDI or ESI techniques (e.g. Langen et al. (1997)) Electrophoresis 18: 1184-1192). Using these techniques, the protein sequences provided herein can be used to identify Corynebacterium glutamicum proteins.

Using the information obtained in this manner, the presence, activity or modification of the protein between different samples from various biological conditions (e.g., different organisms, time of fermentation, media conditions, or different biotopes) You can compare them. The data obtained alone or in combination with other techniques can be used to compare the reactions of various organisms in a given state (e.g., metabolic), to increase the productivity of microorganisms that produce microchemicals, or to increase the production efficiency of microchemicals. It can be applied for various purposes.

Equivalence

Those skilled in the art will recognize or be able to as well as routine experimental methods, as well as many experimental methods equivalent to certain embodiments of the invention described herein. Such equivalent methods will be included in the following claims.

<110> BASF Aktiengesellschaft <120> CORYNEBACTERIUM GLUTAMICUM GENES ENCODING PROTEINS       INVOLVED IN MEMBRANE SYNTHESIS AND MEMBRANE       TRANSPORT <130> BGI-125CPPC <140> PCT / IB00 / 00926 <141> 2000-06-23 <150> US 60/141031 <151> 1999-06-25 <150> DE 19931454.3 <151> 1999-07-08 <150> DE 1993 1478.0 <151> 1999-07-08 <150> DE 1993 1563.9 <151> 1999-07-08 <150> DE 19932122.1 <151> 1999-07-09 <150> DE 19932124.8 <151> 1999-07-09 <150> DE 1993 2125.6 <151> 1999-07-09 <150> DE 1993 2128.0 <151> 1999-07-09 <150> DE 1993 2180.9 <151> 1999-07-09 <150> DE 1993 2182.5 <151> 1999-07-09 <150> DE 1993 2190.6 <151> 1999-07-09 <150> DE 1993 2191.4 <151> 1999-07-09 <150> DE 1993 2209.0 <151> 1999-07-09 <150> DE 19932212.0 <151> 1999-07-09 <150> DE 1993 2227.9 <151> 1999-07-09 <150> DE 19932228.7 <151> 1999-07-09 <150> DE 1993 2229.5 <151> 1999-07-09 <150> DE 19932230.9 <151> 1999-07-09 <150> DE 19932927.3 <151> 1999-07-14 <150> DE 1993 3005.0 <151> 1999-07-14 <150> DE 1993 3006.9 <151> 1999-07-14 <150> DE 19940764.9 <151> 1999-08-27 <150> DE 19940765.7 <151> 1999-08-27 <150> DE 19940766.5 <151> 1999-08-27 <150> DE 19940830.0 <151> 1999-08-27 <150> DE 19940831.9 <151> 1999-08-27 <150> DE 19940832.7 <151> 1999-08-27 <150> DE 19940833.5 <151> 1999-08-27 <150> DE 19941378.9 <151> 1999-08-31 <150> DE 1994 1379.7 <151> 1999-08-31 <150> DE 19941395.9 <151> 1999-08-31 <150> DE 19942077.7 <151> 1999-09-03 <150> DE 1994 2078.5 <151> 1999-09-03 <150> DE 19942079.3 <151> 1999-09-03 <150> DE 19942088.2 <151> 1999-09-03 <160> 678 <210> 1 <211> 578 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (555) <223> RXN03097 <400> 1 att tca gcc agt gca ggt gct ata ggt tgg tta att tta gaa tat att 48 Ile Ser Ala Ser Ala Gly Ala Ile Gly Trp Leu Ile Leu Glu Tyr Ile   1 5 10 15 ttt aaa aag acg aca agt tta ctt gga ctt tta ctc ggt gca tta gca 96 Phe Lys Lys Thr Thr Ser Leu Leu Gly Leu Leu Leu Gly Ala Leu Ala              20 25 30 gga tta gtt gtt att act cct gca gca gga tat gta aca tat ctt agt 144 Gly Leu Val Val Ile Thr Pro Ala Ala Gly Tyr Val Thr Tyr Leu Ser          35 40 45 gca aca ata atg gct tta ata gga ggt atc tgt tgt tat att gtc att 192 Ala Thr Ile Met Ala Leu Ile Gly Gly Ile Cys Cys Tyr Ile Val Ile      50 55 60 aat tac atc aag gta aaa cta aaa tat cat gat gca tta gat gca ttt 240 Asn Tyr Ile Lys Val Lys Leu Lys Tyr His Asp Ala Leu Asp Ala Phe  65 70 75 80 ggt att cat ggt gtt ggt ggt att att ggt gct gtt tta aca gca gtt 288 Gly Ile His Gly Val Gly Gly Ile Gly Ala Val Leu Thr Ala Val                  85 90 95 ttc caa agt aaa aaa gcc aat cct gac att gag aat ggc ttt att tat 336 Phe Gln Ser Lys Lys Ala Asn Pro Asp Ile Glu Asn Gly Phe Ile Tyr             100 105 110 act ggt gac ata cat att ata ctt gta caa ata tta tgt gta aca gca 384 Thr Gly Asp Ile His Ile Ile Leu Val Gln Ile Leu Cys Val Thr Ala         115 120 125 gtt gta att ttt agt atc gtc atg acg ttt att att gcg aaa gta att 432 Val Val Ile Phe Ser Ile Val Met Thr Phe Ile Ila Ala Lys Val Ile     130 135 140 aaa tta att aca cca tta tct gtt acg gaa caa gaa acg aat ata gga 480 Lys Leu Ile Thr Pro Leu Ser Val Thr Glu Gln Glu Thr Asn Ile Gly 145 150 155 160 tta gac aag att gtt cac ggt gaa cat gct tac ttt gaa ggt gag cta 528 Leu Asp Lys Ile Val His Gly Glu His Ala Tyr Phe Glu Gly Glu Leu                 165 170 175 aat aga ttc aat aaa cat att cga tat tagaatatat ttacatagaa tat 578 Asn Arg Phe Asn Lys His Ile Arg Tyr             180 185 <210> 2 <211> 185 <212> PRT <213> Corynebacterium glutamicum <400> 2 Ile Ser Ala Ser Ala Gly Ala Ile Gly Trp Leu Ile Leu Glu Tyr Ile   1 5 10 15 Phe Lys Lys Thr Thr Ser Leu Leu Gly Leu Leu Leu Gly Ala Leu Ala              20 25 30 Gly Leu Val Val Ile Thr Pro Ala Ala Gly Tyr Val Thr Tyr Leu Ser          35 40 45 Ala Thr Ile Met Ala Leu Ile Gly Gly Ile Cys Cys Tyr Ile Val Ile      50 55 60 Asn Tyr Ile Lys Val Lys Leu Lys Tyr His Asp Ala Leu Asp Ala Phe  65 70 75 80 Gly Ile His Gly Val Gly Gly Ile Gly Ala Val Leu Thr Ala Val                  85 90 95 Phe Gln Ser Lys Lys Ala Asn Pro Asp Ile Glu Asn Gly Phe Ile Tyr             100 105 110 Thr Gly Asp Ile His Ile Ile Leu Val Gln Ile Leu Cys Val Thr Ala         115 120 125 Val Val Ile Phe Ser Ile Val Met Thr Phe Ile Ila Ala Lys Val Ile     130 135 140 Lys Leu Ile Thr Pro Leu Ser Val Thr Glu Gln Glu Thr Asn Ile Gly 145 150 155 160 Leu Asp Lys Ile Val His Gly Glu His Ala Tyr Phe Glu Gly Glu Leu                 165 170 175 Asn Arg Phe Asn Lys His Ile Arg Tyr             180 185 <210> 3 <211> 373 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (101) .. (373) <223> RXA02099 <400> 3 tagttagagc tggttcaagg ggtgtcaatc ccaaaaggca ctccttgaac tcatgaaaaa 60 gcttgacaaa acttcaacgt caaaggaggt catccacgct atg ggt gca gat caa 115                                             Met Gly Ala Asp Gln                                               1 5 att gca gca gtc tcc ggc aat tca gct tgg atg ctg atg tcc gcg tcg 163 Ile Ala Ala Val Ser Gly Asn Ser Ala Trp Met Leu Met Ser Ala Ser                  10 15 20 ctc gtg ctg cta atg aca cca gca ctg gca ctt ttc tat ggc ggc atg 211 Leu Val Leu Leu Met Thr Pro Ala Leu Ala Leu Phe Tyr Gly Gly Met              25 30 35 tct cgt caa aag tcc gtg ctc aac atg atg atg atg tcc ttt gga gca 259 Ser Arg Gln Lys Ser Val Leu Asn Met Met Met Met Ser Phe Gly Ala          40 45 50 ttg ggc gtc gtt act gtt att tac ctc ttg tgg gga tgg tcg atg tct 307 Leu Gly Val Val Thr Val Ile Tyr Leu Leu Trp Gly Trp Ser Met Ser      55 60 65 tat gga acc caa tca atc gcg gga atc ttt gct aac cct ttt gag ttc 355 Tyr Gly Thr Gln Ser Ile Ala Gly Ile Phe Ala Asn Pro Phe Glu Phe  70 75 80 85 ttc ggt ctt aaa gat tcc 373 Phe Gly Leu Lys Asp Ser                  90 <210> 4 <211> 91 <212> PRT <213> Corynebacterium glutamicum <400> 4 Met Gly Ala Asp Gln Ile Ala Ala Val Ser Gly Asn Ser Ala Trp Met   1 5 10 15 Leu Met Ser Ala Ser Leu Val Leu Leu Met Thr Pro Ala Leu Ala Leu              20 25 30 Phe Tyr Gly Gly Met Ser Arg Gln Lys Ser Val Leu Asn Met Met Met          35 40 45 Met Ser Phe Gly Ala Leu Gly Val Val Thr Val Ile Tyr Leu Leu Trp      50 55 60 Gly Trp Ser Met Ser Tyr Gly Thr Gln Ser Ile Ala Gly Ile Phe Ala  65 70 75 80 Asn Pro Phe Glu Phe Phe Gly Leu Lys Asp Ser                  85 90 <210> 5 <211> 879 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (856) <223> RXA00104 <400> 5 tgcaaagaca tcccggaacc actccgctac ttgaggtcgg aatcgggaaa gaatgctttt 60 agccatgcct taatgtaacc aaacatctag aattgagaac atg act gct cag att 115                                             Met Thr Ala Gln Ile                                               1 5 gat gat tcg atc ctc acc cat cgt ctc gcc caa ggc acc gga gaa atc 163 Asp Asp Ser Ile Leu Thr His Arg Leu Ala Gln Gly Thr Gly Glu Ile                  10 15 20 ctc aaa ggt gtc cgc aat gtt ggg gtg tta aga ggt cgg aat ctc ggt 211 Leu Lys Gly Val Arg Asn Val Gly Val Leu Arg Gly Arg Asn Leu Gly              25 30 35 gat gcc ggc gac gaa ctc gca caa agt tgg att gct cga gtg ttg gag 259 Asp Ala Gly Asp Glu Leu Ala Gln Ser Trp Ile Ala Arg Val Leu Glu          40 45 50 cag cac cgc ccc aac gat gga ttc ctg tct gaa gaa gcc gcc gac aac 307 Gln His Arg Pro Asn Asp Gly Phe Leu Ser Glu Glu Ala Ala Asp Asn      55 60 65 cca gac cgc cta tcc aag gac cgc gtg tgg atc atc gat ccc ctc gac 355 Pro Asp Arg Leu Ser Lys Asp Arg Val Trp Ile Ile Asp Pro Leu Asp  70 75 80 85 ggc acc aaa gaa ttc gcc acc ggc cgc cag gac tgg gca gta cac atc 403 Gly Thr Lys Glu Phe Ala Thr Gly Arg Gln Asp Trp Ala Val His Ile                  90 95 100 gca ctg gta gaa aac ggt gtt ccc acc cac gcc gct gtt ggc ctc ccc 451 Ala Leu Val Glu Asn Gly Val Pro Thr His Ala Ala Val Gly Leu Pro             105 110 115 gac ctt ggc gtg gtg ttc cac tcc gct gat gcc cgc gcc gtg act ggc 499 Asp Leu Gly Val Val Phe His Ser Ala Asp Ala Arg Ala Val Thr Gly         120 125 130 cct tac tcc aag gtc atc gcc atc tcc cac aac cgc cca cca aag gtt 547 Pro Tyr Ser Lys Val Ile Ala Ile Ser His Asn Arg Pro Pro Lys Val     135 140 145 gct cta tct tgc gca gag cag ctc ggc ttt gaa acc aag gcc ctt gga 595 Ala Leu Ser Cys Ala Glu Gln Leu Gly Phe Glu Thr Lys Ala Leu Gly 150 155 160 165 tcc gca ggc gct aaa gca atg cac gtt ctc ctc ggt gac tac gac gcc 643 Ser Ala Gly Ala Lys Ala Met His Val Leu Leu Gly Asp Tyr Asp Ala                 170 175 180 tac atc cac gcc ggc ggc caa tac gag tgg gat tcc gca gca cca gtc 691 Tyr Ile His Ala Gly Gly Gln Tyr Glu Trp Asp Ser Ala Ala Pro Val             185 190 195 ggc gtc tgc aag gca gca ggc ttg cac tgc tcc agg ctc gac ggt tcc 739 Gly Val Cys Lys Ala Ala Gly Leu His Cys Ser Arg Leu Asp Gly Ser         200 205 210 gag ctg acc tac aac aac aaa gac acc tac atg cca gac atc ttg atc 787 Glu Leu Thr Tyr Asn Asn Lys Asp Thr Tyr Met Pro Asp Ile Leu Ile     215 220 225 tgt cgc cct gaa ctt gca gat gaa ctt ctc gag atg tgc gcg aag ttc 835 Cys Arg Pro Glu Leu Ala Asp Glu Leu Leu Glu Met Cys Ala Lys Phe 230 235 240 245 tac gag gag aat gga act tac taacgctgtt atgatgacgg cat 879 Tyr Glu Glu Asn Gly Thr Tyr                 250 <210> 6 <211> 252 <212> PRT <213> Corynebacterium glutamicum <400> 6 Met Thr Ala Gln Ile Asp Asp Ser Ile Leu Thr His Arg Leu Ala Gln   1 5 10 15 Gly Thr Gly Glu Ile Leu Lys Gly Val Arg Asn Val Gly Val Leu Arg              20 25 30 Gly Arg Asn Leu Gly Asp Ala Gly Asp Glu Leu Ala Gln Ser Trp Ile          35 40 45 Ala Arg Val Leu Glu Gln His Arg Pro Asn Asp Gly Phe Leu Ser Glu      50 55 60 Glu Ala Ala Asp Asn Pro Asp Arg Leu Ser Lys Asp Arg Val Trp Ile  65 70 75 80 Ile Asp Pro Leu Asp Gly Thr Lys Glu Phe Ala Thr Gly Arg Gln Asp                  85 90 95 Trp Ala Val His Ile Ala Leu Val Glu Asn Gly Val Pro Thr His Ala             100 105 110 Ala Val Gly Leu Pro Asp Leu Gly Val Val Phe His Ser Ala Asp Ala         115 120 125 Arg Ala Val Thr Gly Pro Tyr Ser Lys Val Ile Ala Ile Ser His Asn     130 135 140 Arg Pro Pro Lys Val Ala Leu Ser Cys Ala Glu Gln Leu Gly Phe Glu 145 150 155 160 Thr Lys Ala Leu Gly Ser Ala Gly Ala Lys Ala Met His Val Leu Leu                 165 170 175 Gly Asp Tyr Asp Ala Tyr Ile His Ala Gly Gly Gln Tyr Glu Trp Asp             180 185 190 Ser Ala Ala Pro Val Gly Val Cys Lys Ala Ala Gly Leu His Cys Ser         195 200 205 Arg Leu Asp Gly Ser Glu Leu Thr Tyr Asn Asn Lys Asp Thr Tyr Met     210 215 220 Pro Asp Ile Leu Ile Cys Arg Pro Glu Leu Ala Asp Glu Leu Leu Glu 225 230 235 240 Met Cys Ala Lys Phe Tyr Glu Glu Asn Gly Thr Tyr                 245 250 <210> 7 <211> 875 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (859) <223> RXA01420 <400> 7 cgaagttcac gactacaggc attacctggg tgctgatttt gcgcgagtaa agctgtggct 60 gcggaatgcg ctgctcatcc acacgtggaa tcctgattgg gtg acg ctg ggt gga 115                                             Val Thr Leu Gly Gly                                               1 5 ttg aat gta cca tcg tgg tcg ctg ggc gcg gaa atg ctg ttc tac ctg 163 Leu Asn Val Pro Ser Trp Ser Leu Gly Ala Glu Met Leu Phe Tyr Leu                  10 15 20 acg ttc ccg ctg ttt att ccg tta gtg cgc aaa gtg aag ggc gtg ggc 211 Thr Phe Pro Leu Phe Ile Pro Leu Val Arg Lys Val Lys Gly Val Gly              25 30 35 aac tgg tgg gca ttt ggc atc acc ttt gcc gtg agc ctg gcg ctg att 259 Asn Trp Trp Ala Phe Gly Ile Thr Phe Ala Val Ser Leu Ala Leu Ile          40 45 50 aca gtg att cac ttt tat gcg gac gga cca aag ggg att gag aac ttc 307 Thr Val Ile His Phe Tyr Ala Asp Gly Pro Lys Gly Ile Glu Asn Phe      55 60 65 ttt gtt cct cgc ctg tgg gac acc aat gtg tca ccg gtc gcg gaa gtt 355 Phe Val Pro Arg Leu Trp Asp Thr Asn Val Ser Pro Val Ala Glu Val  70 75 80 85 cac gcc gat cca gtg tgg ttt atg cag gaa gaa att ccc gtg ctg gaa 403 His Ala Asp Pro Val Trp Phe Met Gln Glu Glu Ile Pro Val Leu Glu                  90 95 100 tct tac tgg ctg tct tac tac ttc ccg ctg acc aga ctc atc gag ttc 451 Ser Tyr Trp Leu Ser Tyr Tyr Phe Pro Leu Thr Arg Leu Ile Glu Phe             105 110 115 tac ctc ggt gtg ttt ggc gcg aag ctg gtt gct gaa ggc atg ttt aaa 499 Tyr Leu Gly Val Phe Gly Ala Lys Leu Val Ala Glu Gly Met Phe Lys         120 125 130 aac acc aac atc acc atc ccg ctg atc gca ctg gct gtt tct ttt gtt 547 Asn Thr Asn Ile Thr Ile Pro Leu Ile Ala Leu Ala Val Ser Phe Val     135 140 145 gct act tgg ttt gtg cca ctg gca ttc aag atg tct gtc atc atg tcc 595 Ala Thr Trp Phe Val Pro Leu Ala Phe Lys Met Ser Val Ile Met Ser 150 155 160 165 ctg cca atg gct ttt gtt gtg gca acg ctt gcg gtg aga gac att gaa 643 Leu Pro Met Ala Phe Val Val Ala Thr Leu Ala Val Arg Asp Ile Glu                 170 175 180 ggc aag agt ggg gaa atc gcc tcg cct cgc gca gtt ttg ttg ggt aat 691 Gly Lys Ser Gly Glu Ile Ala Ser Pro Arg Ala Val Leu Leu Gly Asn             185 190 195 att tcc ttt gcc ttc tac atg gtg caa ttc ccc gtc atg gtg ttt gtg 739 Ile Ser Phe Ala Phe Tyr Met Val Gln Phe Pro Val Met Val Phe Val         200 205 210 cag cgc tat ttc att gct ggc aaa gaa tac ggc ttc ctt ggc tgg gca 787 Gln Arg Tyr Phe Ile Ala Gly Lys Glu Tyr Gly Phe Leu Gly Trp Ala     215 220 225 ttc tat gca gtg gtg tgt ttc atc gtg tcg gtc att ctc gcg tgg gtg 835 Phe Tyr Ala Val Val Cys Phe Ile Val Ser Val Ile Leu Ala Trp Val 230 235 240 245 ctg tta cct tcg ttg atg atc ctt taataaggcc acggaa 875 Leu Leu Pro Ser Leu Met Ile Leu                 250 <210> 8 <211> 253 <212> PRT <213> Corynebacterium glutamicum <400> 8 Val Thr Leu Gly Gly Leu Asn Val Pro Ser Trp Ser Leu Gly Ala Glu   1 5 10 15 Met Leu Phe Tyr Leu Thr Phe Pro Leu Phe Ile Pro Leu Val Arg Lys              20 25 30 Val Lys Gly Val Gly Asn Trp Trp Ala Phe Gly Ile Thr Phe Ala Val          35 40 45 Ser Leu Ala Leu Ile Thr Val Ile His Phe Tyr Ala Asp Gly Pro Lys      50 55 60 Gly Ile Glu Asn Phe Phe Val Pro Arg Leu Trp Asp Thr Asn Val Ser  65 70 75 80 Pro Val Ala Glu Val His Ala Asp Pro Val Trp Phe Met Gln Glu Glu                  85 90 95 Ile Pro Val Leu Glu Ser Tyr Trp Leu Ser Tyr Tyr Phe Pro Leu Thr             100 105 110 Arg Leu Ile Glu Phe Tyr Leu Gly Val Phe Gly Ala Lys Leu Val Ala         115 120 125 Glu Gly Met Phe Lys Asn Thr Asn Ile Thr Ile Pro Leu Ile Ala Leu     130 135 140 Ala Val Ser Phe Val Ala Thr Trp Phe Val Pro Leu Ala Phe Lys Met 145 150 155 160 Ser Val Ile Met Ser Leu Pro Met Ala Phe Val Val Ala Thr Leu Ala                 165 170 175 Val Arg Asp Ile Glu Gly Lys Ser Gly Glu Ile Ala Ser Pro Arg Ala             180 185 190 Val Leu Leu Gly Asn Ile Ser Phe Ala Phe Tyr Met Val Gln Phe Pro         195 200 205 Val Met Val Phe Val Gln Arg Tyr Phe Ile Ala Gly Lys Glu Tyr Gly     210 215 220 Phe Leu Gly Trp Ala Phe Tyr Ala Val Val Cys Phe Ile Val Ser Val 225 230 235 240 Ile Leu Ala Trp Val Leu Leu Pro Ser Leu Met Ile Leu                 245 250 <210> 9 <211> 1983 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1960) <223> RXN02581 <400> 9 acggtcactc gctcaagtag tgttagtttg caaaagtaat aaaatgttca tctttgtcga 60 tggtcacaat agtcattaaa gaattgtaag aggggttcac atg gat tta gat aaa 115                                             Met Asp Leu Asp Lys                                               1 5 gcg att ggt tca ttc ttc gat gag aat gga gaa atc aac ctt cct cca 163 Ala Ile Gly Ser Phe Phe Asp Glu Asn Gly Glu Ile Asn Leu Pro Pro                  10 15 20 ttc cta act ttg gca gcc atg ggt gag ttc atg tac cag gct gac atc 211 Phe Leu Thr Leu Ala Ala Met Gly Glu Phe Met Tyr Gln Ala Asp Ile              25 30 35 gct gaa ggc ggc ggg gat aaa cca cgc atg cat ttc tgg gac ttc tcc 259 Ala Glu Gly Gly Gly Asp Lys Pro Arg Met His Phe Trp Asp Phe Ser          40 45 50 gaa gac cgc gat ggc aag ctg att cag tac acc cga aac gag atc gat 307 Glu Asp Arg Asp Gly Lys Leu Ile Gln Tyr Thr Arg Asn Glu Ile Asp      55 60 65 act cgt atc aag gct gta gca ggc cgt ttg cag cag gtc gcc acc ctg 355 Thr Arg Ile Lys Ala Val Ala Gly Arg Leu Gln Gln Val Ala Thr Leu  70 75 80 85 ggt gat cgt gca gcg atc ctg gct aac aac agc cct gag tac att ttc 403 Gly Asp Arg Ala Ala Ile Leu Ala Asn Asn Ser Pro Glu Tyr Ile Phe                  90 95 100 agc ttc ctc ggc gcg atc tac gct ggc atg gtc cct gtg ccg ctt tat 451 Ser Phe Leu Gly Ala Ile Tyr Ala Gly Met Val Pro Val Pro Leu Tyr             105 110 115 gat cca aac gag cca gga cac gca gac cac ctc aac gct gtt ttc gca 499 Asp Pro Asn Glu Pro Gly His Ala Asp His Leu Asn Ala Val Phe Ala         120 125 130 gac agc gag cca gtt gtc gtt ctg acc aac tcc aag tcc gca ggt gcc 547 Asp Ser Glu Pro Val Val Val Leu Thr Asn Ser Lys Ser Ala Gly Ala     135 140 145 gtg cgc aag cac ttc tcc agc ctt cca gct gca gaa cgc cca cgc atc 595 Val Arg Lys His Phe Ser Ser Leu Pro Ala Ala Glu Arg Pro Arg Ile 150 155 160 165 ctc tct gta gat tcc ttg cct gat tct ctc gcg gat tct tac gag aac 643 Leu Ser Val Asp Ser Leu Pro Asp Ser Leu Ala Asp Ser Tyr Glu Asn                 170 175 180 cca atg ctg acc gaa gcc ggc cgc cgc ctg gct gct ctg cgc cag tcc 691 Pro Met Leu Thr Glu Ala Gly Arg Arg Leu Ala Ala Leu Arg Gln Ser             185 190 195 gcg ccc att gat ctg acc gca ttc ctg cag tac acc tcc ggc tcc acc 739 Ala Pro Ile Asp Leu Thr Ala Phe Leu Gln Tyr Thr Ser Gly Ser Thr         200 205 210 cga acc cca gct ggc gtt gtt ctg acc aac cgc tcc atc ctg acc aac 787 Arg Thr Pro Ala Gly Val Val Leu Thr Asn Arg Ser Ile Leu Thr Asn     215 220 225 gtc ttg cag atc ttc agc gcc gca cag ctg aaa acc cca ctg cgc ctg 835 Val Leu Gln Ile Phe Ser Ala Ala Gln Leu Lys Thr Pro Leu Arg Leu 230 235 240 245 gtt tca tgg ctg cca ctg cac cac gac atg ggc att atc ctc gcg gcg 883 Val Ser Trp Leu Pro Leu His His Asp Met Gly Ile Ile Leu Ala Ala                 250 255 260 ttt gtc act atg ctt ggc ctg gac aac gag ttc atg aac cca cgc gat 931 Phe Val Thr Met Leu Gly Leu Asp Asn Glu Phe Met Asn Pro Arg Asp             265 270 275 ttc gtg cag cag cct tcc cgc tgg att aag cag ctc aac cgt cgc gaa 979 Phe Val Gln Gln Pro Ser Arg Trp Ile Lys Gln Leu Asn Arg Arg Glu         280 285 290 agc gac gtg gac gtt aac gtc tac acc gtg gtt cct aac ttc gcc ctc 1027 Ser Asp Val Asp Val Asn Val Tyr Thr Val Val Pro Asn Phe Ala Leu     295 300 305 gag ctt gca gca cgc tac gca aag cca gca gag gga gag acc ctg gat 1075 Glu Leu Ala Ala Arg Tyr Ala Lys Pro Ala Glu Gly Glu Thr Leu Asp 310 315 320 325 ctt tcc gca ttg gat gcc atc att atc ggt tcc gag cca gtc aca gaa 1123 Leu Ser Ala Leu Asp Ala Ile Ile Ile Gly Ser Glu Pro Val Thr Glu                 330 335 340 aac gct ctg acc acc ttc cgt gaa gct ttc gag cct tac ggc ctg cct 1171 Asn Ala Leu Thr Thr Phe Arg Glu Ala Phe Glu Pro Tyr Gly Leu Pro             345 350 355 gtt cag acc ctg cgt cct tcc tac ggt ctt gca gaa gca tcc ctg ctg 1219 Val Gln Thr Leu Arg Pro Ser Tyr Gly Leu Ala Glu Ala Ser Leu Leu         360 365 370 gtc acc acc cca cag acc gaa aac cgc cca ctg atc tcc tac ttc gac 1267 Val Thr Thr Pro Gln Thr Glu Asn Arg Pro Leu Ile Ser Tyr Phe Asp     375 380 385 cgc gag gcc ttg gcc gaa aac cgc gtt gag ctt gta gaa aag ggc aat 1315 Arg Glu Ala Leu Ala Glu Asn Arg Val Glu Leu Val Glu Lys Gly Asn 390 395 400 405 aac aag gct gtt gct ttc gtc tcc aac ggc cag gtt gca gcc cca cag 1363 Asn Lys Ala Val Ala Phe Val Ser Asn Gly Gln Val Ala Ala Pro Gln                 410 415 420 cag ctg gtc atc gtt gat tcc gaa acc gga acc gag ctg gca gac ggc 1411 Gln Leu Val Ile Val Asp Ser Glu Thr Gly Thr Glu Leu Ala Asp Gly             425 430 435 cag atc ggc gaa atc tgg acc cac ggc gaa aac act gct gca ggt tac 1459 Gln Ile Gly Glu Ile Trp Thr His Gly Glu Asn Thr Ala Ala Gly Tyr         440 445 450 ctc gac cgc gag gaa gac acc gca gaa acc ttc cgc aac cgt ctg acc 1507 Leu Asp Arg Glu Glu Asp Thr Ala Glu Thr Phe Arg Asn Arg Leu Thr     455 460 465 acc cgc ctg gaa gaa aac tcc cgc gca gaa ggt gct gcc gac gac aac 1555 Thr Arg Leu Glu Glu Asn Ser Arg Ala Glu Gly Ala Ala Asp Asp Asn 470 475 480 485 tac tgg atg gcc acc ggt gac ctc ggc gtc atc gta gac aac gag ctc 1603 Tyr Trp Met Ala Thr Gly Asp Leu Gly Val Ile Val Asp Asn Glu Leu                 490 495 500 tac atc acc ggt cgt ctg aag gac ctc atc gtt gtc gca ggc cga aac 1651 Tyr Ile Thr Gly Arg Leu Lys Asp Leu Ile Val Val Ala Gly Arg Asn             505 510 515 cac tac cca cag gac atc gag tac acc gtc cag gct gct tcc gca cac 1699 His Tyr Pro Gln Asp Ile Glu Tyr Thr Val Gln Ala Ala Ser Ala His         520 525 530 atc cgt gca gat tcc gtc gca gca ttc gca gtc cca ggc gat gac att 1747 Ile Arg Ala Asp Ser Val Ala Ala Phe Ala Val Pro Gly Asp Asp Ile     535 540 545 gaa aag ctc atc atc ctg gca gaa cgc gac acc act gca aac gaa gcc 1795 Glu Lys Leu Ile Ile Leu Ala Glu Arg Asp Thr Thr Ala Asn Glu Ala 550 555 560 565 gac gat gca gct gct gaa gaa gca atc cgc tcc gcc gtt ggc act gca 1843 Asp Asp Ala Ala Ala Glu Glu Ala Ile Arg Ser Ala Val Gly Thr Ala                 570 575 580 cac ggt gtt gtt cca gaa gag atc cgt atc ctc gca cct gac gag atc 1891 His Gly Val Val Pro Glu Glu Ile Arg Ile Leu Ala Pro Asp Glu Ile             585 590 595 gcg cgt tcc tcc tcc gga aag atc gca cgc cgc gtc aac cag cgc aac 1939 Ala Arg Ser Ser Ser Gly Lys Ile Ala Arg Arg Val Asn Gln Arg Asn         600 605 610 tac att cag gaa caa gct aac tagttctttg cagacaccgc agg 1983 Tyr Ile Gln Glu Gln Ala Asn     615 620 <210> 10 <211> 620 <212> PRT <213> Corynebacterium glutamicum <400> 10 Met Asp Leu Asp Lys Ala Ile Gly Ser Phe Phe Asp Glu Asn Gly Glu   1 5 10 15 Ile Asn Leu Pro Pro Phe Leu Thr Leu Ala Ala Met Gly Glu Phe Met              20 25 30 Tyr Gln Ala Asp Ile Ala Glu Gly Gly Gly Asp Lys Pro Arg Met His          35 40 45 Phe Trp Asp Phe Ser Glu Asp Arg Asp Gly Lys Leu Ile Gln Tyr Thr      50 55 60 Arg Asn Glu Ile Asp Thr Arg Ile Lys Ala Val Ala Gly Arg Leu Gln  65 70 75 80 Gln Val Ala Thr Leu Gly Asp Arg Ala Ala Ile Leu Ala Asn Asn Ser                  85 90 95 Pro Glu Tyr Ile Phe Ser Phe Leu Gly Ala Ile Tyr Ala Gly Met Val             100 105 110 Pro Val Pro Leu Tyr Asp Pro Asn Glu Pro Gly His Ala Asp His Leu         115 120 125 Asn Ala Val Phe Ala Asp Ser Glu Pro Val Val Val Leu Thr Asn Ser     130 135 140 Lys Ser Ala Gly Ala Val Arg Lys His Phe Ser Ser Leu Pro Ala Ala 145 150 155 160 Glu Arg Pro Arg Ile Leu Ser Val Asp Ser Leu Pro Asp Ser Leu Ala                 165 170 175 Asp Ser Tyr Glu Asn Pro Met Leu Thr Glu Ala Gly Arg Arg Leu Ala             180 185 190 Ala Leu Arg Gln Ser Ala Pro Ile Asp Leu Thr Ala Phe Leu Gln Tyr         195 200 205 Thr Ser Gly Ser Thr Arg Thr Pro Ala Gly Val Val Leu Thr Asn Arg     210 215 220 Ser Ile Leu Thr Asn Val Leu Gln Ile Phe Ser Ala Ala Gln Leu Lys 225 230 235 240 Thr Pro Leu Arg Leu Val Ser Trp Leu Pro Leu His His Asp Met Gly                 245 250 255 Ile Ile Leu Ala Ala Phe Val Thr Met Leu Gly Leu Asp Asn Glu Phe             260 265 270 Met Asn Pro Arg Asp Phe Val Gln Gln Pro Ser Arg Trp Ile Lys Gln         275 280 285 Leu Asn Arg Arg Glu Ser Asp Val Asp Val Asn Val Tyr Thr Val Val     290 295 300 Pro Asn Phe Ala Leu Glu Leu Ala Ala Arg Tyr Ala Lys Pro Ala Glu 305 310 315 320 Gly Glu Thr Leu Asp Leu Ser Ala Leu Asp Ala Ile Ile Ile Gly Ser                 325 330 335 Glu Pro Val Thr Glu Asn Ala Leu Thr Thr Phe Arg Glu Ala Phe Glu             340 345 350 Pro Tyr Gly Leu Pro Val Gln Thr Leu Arg Pro Ser Tyr Gly Leu Ala         355 360 365 Glu Ala Ser Leu Leu Val Thr Thr Pro Gln Thr Glu Asn Arg Pro Leu     370 375 380 Ile Ser Tyr Phe Asp Arg Glu Ala Leu Ala Glu Asn Arg Val Glu Leu 385 390 395 400 Val Glu Lys Gly Asn Asn Lys Ala Val Ala Phe Val Ser Asn Gly Gln                 405 410 415 Val Ala Ala Pro Gln Gln Leu Val Ile Val Asp Ser Glu Thr Gly Thr             420 425 430 Glu Leu Ala Asp Gly Gln Ile Gly Glu Ile Trp Thr His Gly Glu Asn         435 440 445 Thr Ala Ala Gly Tyr Leu Asp Arg Glu Glu Asp Thr Ala Glu Thr Phe     450 455 460 Arg Asn Arg Leu Thr Thr Arg Leu Glu Glu Asn Ser Arg Ala Glu Gly 465 470 475 480 Ala Ala Asp Asp Asn Tyr Trp Met Ala Thr Gly Asp Leu Gly Val Ile                 485 490 495 Val Asp Asn Glu Leu Tyr Ile Thr Gly Arg Leu Lys Asp Leu Ile Val             500 505 510 Val Ala Gly Arg Asn His Tyr Pro Gln Asp Ile Glu Tyr Thr Val Gln         515 520 525 Ala Ala Ser Ala His Ile Arg Ala Asp Ser Val Ala Ala Phe Ala Val     530 535 540 Pro Gly Asp Asp Ile Glu Lys Leu Ile Ile Leu Ala Glu Arg Asp Thr 545 550 555 560 Thr Ala Asn Glu Ala Asp Asp Ala Ala Ala Glu Glu Ala Ile Arg Ser                 565 570 575 Ala Val Gly Thr Ala His Gly Val Val Pro Glu Glu Ile Arg Ile Leu             580 585 590 Ala Pro Asp Glu Ile Ala Arg Ser Ser Ser Gly Lys Ile Ala Arg Arg         595 600 605 Val Asn Gln Arg Asn Tyr Ile Gln Glu Gln Ala Asn     610 615 620 <210> 11 <211> 1550 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (1527) <223> FRXA02581 <400> 11 gtc cct gtg ccg ctt tat gat cca aac gag cca gga cac gca gac cac 48 Val Pro Val Pro Leu Tyr Asp Pro Asn Glu Pro Gly His Ala Asp His   1 5 10 15 ctc aac gct gtt ttc gca gac agc gag cca gtt gtc gtt ctg acc aac 96 Leu Asn Ala Val Phe Ala Asp Ser Glu Pro Val Val Val Leu Thr Asn              20 25 30 tcc aag tcc gca ggt gcc gtg cgc aag cac ttc tcc agc ctt cca gct 144 Ser Lys Ser Ala Gly Ala Val Arg Lys His Phe Ser Ser Leu Pro Ala          35 40 45 gca gaa cgc cca cgc atc ctc tct gta gat tcc ttg cct gat tct ctc 192 Ala Glu Arg Pro Arg Ile Leu Ser Val Asp Ser Leu Pro Asp Ser Leu      50 55 60 gcg gat tct tac gag aac cca atg ctg acc gaa gcc ggc cgc cgc ctg 240 Ala Asp Ser Tyr Glu Asn Pro Met Leu Thr Glu Ala Gly Arg Arg Leu  65 70 75 80 gct gct ctg cgc cag tcc gcg ccc att gat ctg acc gca ttc ctg cag 288 Ala Ala Leu Arg Gln Ser Ala Pro Ile Asp Leu Thr Ala Phe Leu Gln                  85 90 95 tac acc tcc ggc tcc acc cga acc cca gct ggc gtt gtt ctg acc aac 336 Tyr Thr Ser Gly Ser Thr Arg Thr Pro Ala Gly Val Val Leu Thr Asn             100 105 110 cgc tcc atc ctg acc aac gtc ttg cag atc ttc agc gcc gca cag ctg 384 Arg Ser Ile Leu Thr Asn Val Leu Gln Ile Phe Ser Ala Ala Gln Leu         115 120 125 aaa acc cca ctg cgc ctg gtt tca tgg ctg cca ctg cac cac gac atg 432 Lys Thr Pro Leu Arg Leu Val Ser Trp Leu Pro Leu His His Asp Met     130 135 140 ggc att atc ctc gcg gcg ttt gtc act atg ctt ggc ctg gac aac gag 480 Gly Ile Ile Leu Ala Ala Phe Val Thr Met Leu Gly Leu Asp Asn Glu 145 150 155 160 ttc atg aac cca cgc gat ttc gtg cag cag cct tcc cgc tgg att aag 528 Phe Met Asn Pro Arg Asp Phe Val Gln Gln Pro Ser Arg Trp Ile Lys                 165 170 175 cag ctc aac cgt cgc gaa agc gac gtg gac gtt aac gtc tac acc gtg 576 Gln Leu Asn Arg Arg Glu Ser Asp Val Asp Val Asn Val Tyr Thr Val             180 185 190 gtt cct aac ttc gcc ctc gag ctt gca gca cgc tac gca aag cca gca 624 Val Pro Asn Phe Ala Leu Glu Leu Ala Ala Arg Tyr Ala Lys Pro Ala         195 200 205 gag gga gag acc ctg gat ctt tcc gca ttg gat gcc atc att atc ggt 672 Glu Gly Glu Thr Leu Asp Leu Ser Ala Leu Asp Ala Ile Ile Ily Gly     210 215 220 tcc gag cca gtc aca gaa aac gct ctg acc acc ttc cgt gaa gct ttc 720 Ser Glu Pro Val Thr Glu Asn Ala Leu Thr Thr Phe Arg Glu Ala Phe 225 230 235 240 gag cct tac ggc ctg cct gtt cag acc ctg cgt cct tcc tac ggt ctt 768 Glu Pro Tyr Gly Leu Pro Val Gln Thr Leu Arg Pro Ser Tyr Gly Leu                 245 250 255 gca gaa gca tcc ctg ctg gtc acc acc cca cag acc gaa aac cgc cca 816 Ala Glu Ala Ser Leu Leu Val Thr Thr Pro Gln Thr Glu Asn Arg Pro             260 265 270 ctg atc tcc tac ttc gac cgc gag gcc ttg gcc gaa aac cgc gtt gag 864 Leu Ile Ser Tyr Phe Asp Arg Glu Ala Leu Ala Glu Asn Arg Val Glu         275 280 285 ctt gta gaa aag ggc aat aac aag gct gtt gct ttc gtc tcc aac ggc 912 Leu Val Glu Lys Gly Asn Asn Lys Ala Val Ala Phe Val Ser Asn Gly     290 295 300 cag gtt gca gcc cca cag cag ctg gtc atc gtt gat tcc gaa acc gga 960 Gln Val Ala Ala Pro Gln Gln Leu Val Ile Val Asp Ser Glu Thr Gly 305 310 315 320 acc gag ctg gca gac ggc cag atc ggc gaa atc tgg acc cac ggc gaa 1008 Thr Glu Leu Ala Asp Gly Gln Ile Gly Glu Ile Trp Thr His Gly Glu                 325 330 335 aac act gct gca ggt tac ctc gac cgc gag gaa gac acc gca gaa acc 1056 Asn Thr Ala Ala Gly Tyr Leu Asp Arg Glu Glu Asp Thr Ala Glu Thr             340 345 350 ttc cgc aac cgt ctg acc acc cgc ctg gaa gaa aac tcc cgc gca gaa 1104 Phe Arg Asn Arg Leu Thr Thr Arg Leu Glu Glu Asn Ser Arg Ala Glu         355 360 365 ggt gct gcc gac gac aac tac tgg atg gcc acc ggt gac ctc ggc gtc 1152 Gly Ala Ala Asp Asp Asn Tyr Trp Met Ala Thr Gly Asp Leu Gly Val     370 375 380 atc gta gac aac gag ctc tac atc acc ggt cgt ctg aag gac ctc atc 1200 Ile Val Asp Asn Glu Leu Tyr Ile Thr Gly Arg Leu Lys Asp Leu Ile 385 390 395 400 gtt gtc gca ggc cga aac cac tac cca cag gac atc gag tac acc gtc 1248 Val Val Ala Gly Arg Asn His Tyr Pro Gln Asp Ile Glu Tyr Thr Val                 405 410 415 cag gct gct tcc gca cac atc cgt gca gat tcc gtc gca gca ttc gca 1296 Gln Ala Ala Ser Ala His Ile Arg Ala Asp Ser Val Ala Ala Phe Ala             420 425 430 gtc cca ggc gat gac att gaa aag ctc atc atc ctg gca gaa cgc gac 1344 Val Pro Gly Asp Asp Ile Glu Lys Leu Ile Ile Leu Ala Glu Arg Asp         435 440 445 acc act gca aac gaa gcc gac gat gca gct gct gaa gaa gca atc cgc 1392 Thr Thr Ala Asn Glu Ala Asp Asp Ala Ala Ala Glu Glu Ala Ile Arg     450 455 460 tcc gcc gtt ggc act gca cac ggt gtt gtt cca gaa gag atc cgt atc 1440 Ser Ala Val Gly Thr Ala His Gly Val Val Pro Glu Glu Ile Arg Ile 465 470 475 480 ctc gca cct gac gag atc gcg cgt tcc tcc tcc gga aag atc gca cgc 1488 Leu Ala Pro Asp Glu Ile Ala Arg Ser Ser Ser Gly Lys Ile Ala Arg                 485 490 495 cgc gtc aac cag cgc aac tac att cag gaa caa gct aac tagttctttg 1537 Arg Val Asn Gln Arg Asn Tyr Ile Gln Glu Gln Ala Asn             500 505 cagacaccgc agg 1550 <210> 12 <211> 509 <212> PRT <213> Corynebacterium glutamicum <400> 12 Val Pro Val Pro Leu Tyr Asp Pro Asn Glu Pro Gly His Ala Asp His   1 5 10 15 Leu Asn Ala Val Phe Ala Asp Ser Glu Pro Val Val Val Leu Thr Asn              20 25 30 Ser Lys Ser Ala Gly Ala Val Arg Lys His Phe Ser Ser Leu Pro Ala          35 40 45 Ala Glu Arg Pro Arg Ile Leu Ser Val Asp Ser Leu Pro Asp Ser Leu      50 55 60 Ala Asp Ser Tyr Glu Asn Pro Met Leu Thr Glu Ala Gly Arg Arg Leu  65 70 75 80 Ala Ala Leu Arg Gln Ser Ala Pro Ile Asp Leu Thr Ala Phe Leu Gln                  85 90 95 Tyr Thr Ser Gly Ser Thr Arg Thr Pro Ala Gly Val Val Leu Thr Asn             100 105 110 Arg Ser Ile Leu Thr Asn Val Leu Gln Ile Phe Ser Ala Ala Gln Leu         115 120 125 Lys Thr Pro Leu Arg Leu Val Ser Trp Leu Pro Leu His His Asp Met     130 135 140 Gly Ile Ile Leu Ala Ala Phe Val Thr Met Leu Gly Leu Asp Asn Glu 145 150 155 160 Phe Met Asn Pro Arg Asp Phe Val Gln Gln Pro Ser Arg Trp Ile Lys                 165 170 175 Gln Leu Asn Arg Arg Glu Ser Asp Val Asp Val Asn Val Tyr Thr Val             180 185 190 Val Pro Asn Phe Ala Leu Glu Leu Ala Ala Arg Tyr Ala Lys Pro Ala         195 200 205 Glu Gly Glu Thr Leu Asp Leu Ser Ala Leu Asp Ala Ile Ile Ily Gly     210 215 220 Ser Glu Pro Val Thr Glu Asn Ala Leu Thr Thr Phe Arg Glu Ala Phe 225 230 235 240 Glu Pro Tyr Gly Leu Pro Val Gln Thr Leu Arg Pro Ser Tyr Gly Leu                 245 250 255 Ala Glu Ala Ser Leu Leu Val Thr Thr Pro Gln Thr Glu Asn Arg Pro             260 265 270 Leu Ile Ser Tyr Phe Asp Arg Glu Ala Leu Ala Glu Asn Arg Val Glu         275 280 285 Leu Val Glu Lys Gly Asn Asn Lys Ala Val Ala Phe Val Ser Asn Gly     290 295 300 Gln Val Ala Ala Pro Gln Gln Leu Val Ile Val Asp Ser Glu Thr Gly 305 310 315 320 Thr Glu Leu Ala Asp Gly Gln Ile Gly Glu Ile Trp Thr His Gly Glu                 325 330 335 Asn Thr Ala Ala Gly Tyr Leu Asp Arg Glu Glu Asp Thr Ala Glu Thr             340 345 350 Phe Arg Asn Arg Leu Thr Thr Arg Leu Glu Glu Asn Ser Arg Ala Glu         355 360 365 Gly Ala Ala Asp Asp Asn Tyr Trp Met Ala Thr Gly Asp Leu Gly Val     370 375 380 Ile Val Asp Asn Glu Leu Tyr Ile Thr Gly Arg Leu Lys Asp Leu Ile 385 390 395 400 Val Val Ala Gly Arg Asn His Tyr Pro Gln Asp Ile Glu Tyr Thr Val                 405 410 415 Gln Ala Ala Ser Ala His Ile Arg Ala Asp Ser Val Ala Ala Phe Ala             420 425 430 Val Pro Gly Asp Asp Ile Glu Lys Leu Ile Ile Leu Ala Glu Arg Asp         435 440 445 Thr Thr Ala Asn Glu Ala Asp Asp Ala Ala Ala Glu Glu Ala Ile Arg     450 455 460 Ser Ala Val Gly Thr Ala His Gly Val Val Pro Glu Glu Ile Arg Ile 465 470 475 480 Leu Ala Pro Asp Glu Ile Ala Arg Ser Ser Ser Gly Lys Ile Ala Arg                 485 490 495 Arg Val Asn Gln Arg Asn Tyr Ile Gln Glu Gln Ala Asn             500 505 <210> 13 <211> 4953 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (4930) <223> RXA02582 <400> 13 tggatgtcta ttctcctcag cctcgttttg gttgaggcgg atagttttaa tattttttta 60 agtttaagtt gtaatcgagc tgaaaggctg aggcctcaat atg gaa cag agc caa 115                                             Met Glu Gln Ser Gln                                               1 5 tcg tcg gat cag aag atg acc gtt gaa cag gtt cgc acc tgg ctc cgt 163 Ser Ser Asp Gln Lys Met Thr Val Glu Gln Val Arg Thr Trp Leu Arg                  10 15 20 gat tgg gtt gtc cgc acc acg ggt att ccg gtg gag gaa gtt acg gat 211 Asp Trp Val Val Arg Thr Thr Gly Ile Pro Val Glu Glu Val Thr Asp              25 30 35 gac aag gca atg gag acc ttt ggc ctt tcc tct cgc gat gtt gtt gtg 259 Asp Lys Ala Met Glu Thr Phe Gly Leu Ser Ser Arg Asp Val Val Val          40 45 50 ttg tct ggt gag ctg gaa aac ctg ctg gac acc tcc ttg gat gcc acc 307 Leu Ser Gly Glu Leu Glu Asn Leu Leu Asp Thr Ser Leu Asp Ala Thr      55 60 65 atc gct tat gag tac cca acg atc cgt agt ttg gcg cag cgc ctt gtt 355 Ile Ala Tyr Glu Tyr Pro Thr Ile Arg Ser Leu Ala Gln Arg Leu Val  70 75 80 85 gag ggc gag cct cgt cgt gca cat acc cag cgt gaa ttg aat ttc tcc 403 Glu Gly Glu Pro Arg Arg Ala His Thr Gln Arg Glu Leu Asn Phe Ser                  90 95 100 gcg gtg agc gat tcc cca ggt tcc cac gat att gcg gtt gtc ggt atg 451 Ala Val Ser Asp Ser Pro Gly Ser His Asp Ile Ala Val Val Gly Met             105 110 115 gct gcg cgt tac cca ggc gct gag agc ctg gag gat atg tgg aag cta 499 Ala Ala Arg Tyr Pro Gly Ala Glu Ser Leu Glu Asp Met Trp Lys Leu         120 125 130 ctc gtc gag ggc cgt gac ggt atc tcg gat cta ccg att ggc cgt tgg 547 Leu Val Glu Gly Arg Asp Gly Ile Ser Asp Leu Pro Ile Gly Arg Trp     135 140 145 tct gag tat gca ggc gat gag gtt atg tct cgg aag atg gaa gag ttt 595 Ser Glu Tyr Ala Gly Asp Glu Val Met Ser Arg Lys Met Glu Glu Phe 150 155 160 165 tct acc atc ggt ggc tac ctg tca gat atc tct agc ttt gat gcg gag 643 Ser Thr Ile Gly Gly Tyr Leu Ser Asp Ile Ser Ser Phe Asp Ala Glu                 170 175 180 ttc ttt ggt ctg tct ccg ctc gag gcc gcc aac atg gat cct cag cag 691 Phe Phe Gly Leu Ser Pro Leu Glu Ala Ala Asn Met Asp Pro Gln Gln             185 190 195 cgt att ttg ctg gag cta acg tgg gag gct ttg gag tac gct cgc atc 739 Arg Ile Leu Leu Glu Leu Thr Trp Glu Ala Leu Glu Tyr Ala Arg Ile         200 205 210 gca cca aac act ttg cgt ggc gaa gcc gtg ggc gtg ttc ata ggt tcc 787 Ala Pro Asn Thr Leu Arg Gly Glu Ala Val Gly Val Phe Ile Gly Ser     215 220 225 tcc aac aac gat tac ggc atg atg atc gct gcc gat cca gca gaa gca 835 Ser Asn Asn Asp Tyr Gly Met Met Ile Ala Ala Asp Pro Ala Glu Ala 230 235 240 245 cat cct tat gcg ctg act ggt act tct agt gcg att gtc gct aac cgc 883 His Pro Tyr Ala Leu Thr Gly Thr Ser Ser Ala Ile Val Ala Asn Arg                 250 255 260 att aac tac gct ttc gat ttc cgc ggt cct tcc gtc aac gtg gat acc 931 Ile Asn Tyr Ala Phe Asp Phe Arg Gly Pro Ser Val Asn Val Asp Thr             265 270 275 gca tgt tct tct tct ctg gta gcg gtt cac cag gct gtc cgt gcg ctg 979 Ala Cys Ser Ser Ser Le Le Val Ala Val His Gln Ala Val Arg Ala Leu         280 285 290 cgt aat ggc gaa gcg gat cac gct atc gct ggt gga gtg aac att ttg 1027 Arg Asn Gly Glu Ala Asp His Ala Ile Ala Gly Gly Val Asn Ile Leu     295 300 305 gca tct cca ttt gtc aca act gca ttc gct gag ctc ggt gtg atc agc 1075 Ala Ser Pro Phe Val Thr Thr Ala Phe Ala Glu Leu Gly Val Ile Ser 310 315 320 325 cca acc ggc aag atc cac gca ttc tct gat gat gcc gat ggt ttc gtg 1123 Pro Thr Gly Lys Ile His Ala Phe Ser Asp Asp Ala Asp Gly Phe Val                 330 335 340 cgt tcc gac ggc gcc gga gtc gtt gtg ctg aag cgc gtg gat gac gca 1171 Arg Ser Asp Gly Ala Gly Val Val Val Leu Lys Arg Val Asp Asp Ala             345 350 355 atc cgc gac ggc gac aag atc atc ggt gtg atc aag ggt tct gca gtg 1219 Ile Arg Asp Gly Asp Lys Ile Ile Gly Val Ile Lys Gly Ser Ala Val         360 365 370 aac tcc gat ggt cac tcc aac gga ctg acc gct cca aac cct gac gca 1267 Asn Ser Asp Gly His Ser Asn Gly Leu Thr Ala Pro Asn Pro Asp Ala     375 380 385 cag gtt gat gtg ctg cag cgt gca tat gtt gac gct cag gtt gat ccc 1315 Gln Val Asp Val Leu Gln Arg Ala Tyr Val Asp Ala Gln Val Asp Pro 390 395 400 405 acc acc gtg gat tac gtt gag gct cac ggc acc ggc acc atc ctg ggt 1363 Thr Thr Val Asp Tyr Val Glu Ala His Gly Thr Gly Thr Ile Leu Gly                 410 415 420 gac ccc att gaa gca act gcc ctg ggt gct gtt ttg ggc tat ggc cgt 1411 Asp Pro Ile Glu Ala Thr Ala Leu Gly Ala Val Leu Gly Tyr Gly Arg             425 430 435 gac gca tcc acc cca act ctt ctg ggc tct gca aag tcc aac ttc ggc 1459 Asp Ala Ser Thr Pro Thr Leu Leu Gly Ser Ala Lys Ser Asn Phe Gly         440 445 450 cac act gag tca gct gcg ggt att gca ggt gtc atc aag gtg ctg ctt 1507 His Thr Glu Ser Ala Ala Gly Ile Ala Gly Val Ile Lys Val Leu Leu     455 460 465 gct ttg cag aac aag act ctg cca cca acc gtg aac ttt gca ggt cca 1555 Ala Leu Gln Asn Lys Thr Leu Pro Pro Thr Val Asn Phe Ala Gly Pro 470 475 480 485 aac cgc tac atc gat ttc gat gct gag cgt ttg gaa gtt gtg gaa gat 1603 Asn Arg Tyr Ile Asp Phe Asp Ala Glu Arg Leu Glu Val Val Glu Asp                 490 495 500 cca cgt gaa tgg ccg gaa tac aac ggt cac gca gta gct ggt gtg tct 1651 Pro Arg Glu Trp Pro Glu Tyr Asn Gly His Ala Val Ala Gly Val Ser             505 510 515 gcg ttc ggg ttc ggt gga acc aac gcg cac gtg gtg atc tct gag tac 1699 Ala Phe Gly Phe Gly Gly Thr Asn Ala His Val Val Ile Ser Glu Tyr         520 525 530 aac gca gaa gac tac gaa acc cgt gcc ccg aag gag gcg ttg ctt cct 1747 Asn Ala Glu Asp Tyr Glu Thr Arg Ala Pro Lys Glu Ala Leu Leu Pro     535 540 545 gac cag cag gtt gcc ctg ccg gtg tct ggt cac ctg cca tcc agg cgt 1795 Asp Gln Gln Val Ala Leu Pro Val Ser Gly His Leu Pro Ser Arg Arg 550 555 560 565 cga caa gca gct gct gac ttg gcg gac ttc ttg gag ggc cgc aaa gat 1843 Arg Gln Ala Ala Ala Asp Leu Ala Asp Phe Leu Glu Gly Arg Lys Asp                 570 575 580 tgc gac cta acc cca gta gcc cgc gcg ctg gca ggc cgc aat cat ggc 1891 Cys Asp Leu Thr Pro Val Ala Arg Ala Leu Ala Gly Arg Asn His Gly             585 590 595 cgc tcc cgc gca gtc gtg ctt gca agc act atc gag gaa gcc gta aag 1939 Arg Ser Arg Ala Val Val Leu Ala Ser Thr Ile Glu Glu Ala Val Lys         600 605 610 cgc ctg cgc cag gtc gca gaa ggc aag gtc agc gtc ggt atc tcc gca 1987 Arg Leu Arg Gln Val Ala Glu Gly Lys Val Ser Val Gly Ile Ser Ala     615 620 625 gct gat tcc cca gcg gcc aac ggt cct gtg ttt gtg tac tcc ggt ttc 2035 Ala Asp Ser Pro Ala Ala Asn Gly Pro Val Phe Val Tyr Ser Gly Phe 630 635 640 645 gga tcc cag cac cgc ctc atg atc aag gaa ttg tgc tca att tcg cca 2083 Gly Ser Gln His Arg Leu Met Ile Lys Glu Leu Cys Ser Ile Ser Pro                 650 655 660 cag ttc cgc gag cgc atc gaa gag ctc gat gaa atg gtt aag ttc gag 2131 Gln Phe Arg Glu Arg Ile Glu Glu Leu Asp Glu Met Val Lys Phe Glu             665 670 675 tcc ggc tgg tcc atc atg aaa ctt gtt ttg gat gat gag caa act tac 2179 Ser Gly Trp Ser Ile Met Lys Leu Val Leu Asp Asp Glu Gln Thr Tyr         680 685 690 gac acc gag acc gcg cag gtt gtg atc acc gca atc cag atc gca ctg 2227 Asp Thr Glu Thr Ala Gln Val Val Ile Thr Ala Ile Gln Ile Ala Leu     695 700 705 act gac ctg ttg gca agc ttc ggt gta aag cca gct gcc gtc atg ggc 2275 Thr Asp Leu Leu Ala Ser Phe Gly Val Lys Pro Ala Ala Val Met Gly 710 715 720 725 atg tcg atg ggt gag atc gct gcc gct tac gct gcc ggt gga ctc agc 2323 Met Ser Met Gly Glu Ile Ala Ala Ala Tyr Ala Ala Gly Gly Leu Ser                 730 735 740 gac cgc gat acc atg ctc att gcc agc cac cgt tcc cgc cta atg ggc 2371 Asp Arg Asp Thr Met Leu Ile Ala Ser His Arg Ser Arg Leu Met Gly             745 750 755 gag ggc gag aag tcc ctg gct gag gat cag ctg ggt gcc atg gct gtg 2419 Glu Gly Glu Lys Ser Leu Ala Glu Asp Gln Leu Gly Ala Met Ala Val         760 765 770 gtg gaa ttc gcc gct gcg gac ctg gat aag ttc atc gaa gaa aac cct 2467 Val Glu Phe Ala Ala Ala Asp Leu Asp Lys Phe Ile Glu Glu Asn Pro     775 780 785 gag tac aag ggc att gag cct gct gtt tat gca ggc cca ggc atg act 2515 Glu Tyr Lys Gly Ile Glu Pro Ala Val Tyr Ala Gly Pro Gly Met Thr 790 795 800 805 acc gtg ggt gga cct cgc gac gcc gtg gtt cag ttc gta gag aag ctg 2563 Thr Val Gly Gly Pro Arg Asp Ala Val Val Gln Phe Val Glu Lys Leu                 810 815 820 gaa tct gaa gac aag ttt gcc cgc ctg ctc aac gtc aag ggc gct ggc 2611 Glu Ser Glu Asp Lys Phe Ala Arg Leu Leu Asn Val Lys Gly Ala Gly             825 830 835 cac acc tct gct gtg gaa cca ctt ctt ggt gag ctc gct ggc gaa atc 2659 His Thr Ser Ala Val Glu Pro Leu Leu Gly Glu Leu Ala Gly Glu Ile         840 845 850 gct ggc atc gag cca ctt ccg ctg cag atc ccg ttg ttc agc tct gtc 2707 Ala Gly Ile Glu Pro Leu Pro Leu Gln Ile Pro Leu Phe Ser Ser Val     855 860 865 gat cag ggt gtt acc tac cca gtt gga gca gtg gtc cac gac gcc gat 2755 Asp Gln Gly Val Thr Tyr Pro Val Gly Ala Val Val His Asp Ala Asp 870 875 880 885 tac atg ctc cgc tgt acc cgc cag tcc gtg tac ttc cag gac tcc acc 2803 Tyr Met Leu Arg Cys Thr Arg Gln Ser Val Tyr Phe Gln Asp Ser Thr                 890 895 900 gaa gct gca ttc gct gca ggc cac aac acc ttg gtg gaa att tcc ccg 2851 Glu Ala Ala Phe Ala Ala Gly His Asn Thr Leu Val Glu Ile Ser Pro             905 910 915 aac cca gtt gca ctc atg ggc atg atg aac acc gcg ttc acc gtg ggc 2899 Asn Pro Val Ala Leu Met Gly Met Met Asn Thr Ala Phe Thr Val Gly         920 925 930 aag cct gat gca cag ctg ctg ttc agc ctg aag cga aaa gtc cca gag 2947 Lys Pro Asp Ala Gln Leu Leu Phe Ser Leu Lys Arg Lys Val Pro Glu     935 940 945 gca gaa tcc ctc cgc gac ctt ctg gcg aag ctg tac gtc aac ggc gca 2995 Ala Glu Ser Leu Arg Asp Leu Leu Ala Lys Leu Tyr Val Asn Gly Ala 950 955 960 965 aac gtt gat ttc tcc gcg ctg tac ggc gaa ggt gaa acc atc gat ccg 3043 Asn Val Asp Phe Ser Ala Leu Tyr Gly Glu Gly Glu Thr Ile Asp Pro                 970 975 980 cca cac atc acc tgg aag cac cag cgc ttc tgg act tcc gca cgc cca 3091 Pro His Ile Thr Trp Lys His Gln Arg Phe Trp Thr Ser Ala Arg Pro             985 990 995 tcc tct ggc gca tcc ctg gat ctg ccg ggc ttc cgc gtg aat ctg cca 3139 Ser Ser Gly Ala Ser Leu Asp Leu Pro Gly Phe Arg Val Asn Leu Pro         1000 1005 1010 aac aac act gtg gcg ttt tcc acc gca gcc gaa ctg gca cca tcc gca 3187 Asn Asn Thr Val Ala Phe Ser Thr Ala Ala Glu Leu Ala Pro Ser Ala     1015 1020 1025 gtg gca atc atg gaa gca gcc gcc atg gct gtc acc cca ggt tcc tcc 3235 Val Ala Ile Met Glu Ala Ala Ala Met Ala Val Thr Pro Gly Ser Ser 1030 1035 1040 1045 gtc gac gca gtg gac gag cgc gac atg ctg cca cca agc ggc gaa atc 3283 Val Asp Ala Val Asp Glu Arg Asp Met Leu Pro Pro Ser Gly Glu Ile                 1050 1055 1060 acc acc atc gtg act cgc tcc ttg ggc ggt ttg agc ctg tcc gta tac 3331 Thr Thr Ile Val Thr Arg Ser Leu Gly Gly Leu Ser Leu Ser Val Tyr             1065 1070 1075 aag att gag gga acc acc agc act ctt gtc gcc gaa ggt ttc gca gcc 3379 Lys Ile Glu Gly Thr Thr Ser Thr Leu Val Ala Glu Gly Phe Ala Ala         1080 1085 1090 aac cca gga ttc gcc gca gca tct tcc ttc gac ggt cca ggc tac gac 3427 Asn Pro Gly Phe Ala Ala Ala Ser Ser Phe Asp Gly Pro Gly Tyr Asp     1095 1100 1105 gga ttc aac acc gat tac agc gac cag cca gac cct cgc tcc gac ctg 3475 Gly Phe Asn Thr Asp Tyr Ser Asp Gln Pro Asp Pro Arg Ser Asp Leu 1110 1115 1120 1125 cct ttg gac atc gaa gca gtc cgc tgg gac cca gcg acc gaa acc gtc 3523 Pro Leu Asp Ile Glu Ala Val Arg Trp Asp Pro Ala Thr Glu Thr Val                 1130 1135 1140 gaa gag cgc atg cgc gcc atc gtc tcc gaa gca atg ggc tac gac gtg 3571 Glu Glu Arg Met Arg Ala Ile Val Ser Glu Ala Met Gly Tyr Asp Val             1145 1150 1155 gat gac ctc cca cgc gaa ctc cca ctg att gac ctc ggc ctc gac tcc 3619 Asp Asp Leu Pro Arg Glu Leu Pro Leu Ile Asp Leu Gly Leu Asp Ser         1160 1165 1170 ctc atg ggc atg cgc atc aaa aac cgc atc gaa aat gac ttc cag atc 3667 Leu Met Gly Met Arg Ile Lys Asn Arg Ile Glu Asn Asp Phe Gln Ile     1175 1180 1185 cca cca ctc cag gtc caa gcg ctc cgc gat gca tcc gtc gct gac gtg 3715 Pro Pro Leu Gln Val Gln Ala Leu Arg Asp Ala Ser Val Ala Asp Val 1190 1195 1200 1205 gta atc atg gtg gaa aac atg gtc gct ggc cgc tcc tct gag acg ctt 3763 Val Ile Met Val Glu Asn Met Val Ala Gly Arg Ser Ser Glu Thr Leu                 1210 1215 1220 gtc gac gcc acc ccg cag gtg cca gct gag gca gca ggg gag gct caa 3811 Val Asp Ala Thr Pro Gln Val Pro Ala Glu Ala Ala Gly Glu Ala Gln             1225 1230 1235 gct gct gag tct tct gct tcg ggc gag gac gtg cag ggc gtt ggc gtt 3859 Ala Ala Glu Ser Ser Ala Ser Gly Glu Asp Val Gln Gly Val Gly Val         1240 1245 1250 gca ccg cga gat gcg tcg gaa cgc atg gtc ttt ggt act tgg gca ggc 3907 Ala Pro Arg Asp Ala Ser Glu Arg Met Val Phe Gly Thr Trp Ala Gly     1255 1260 1265 ctg act ggc gct gcg gca gct ggc gtg acc agc aag ttg cca cag atc 3955 Leu Thr Gly Ala Ala Ala Ala Gly Val Thr Ser Ser Lys Leu Pro Gln Ile 1270 1275 1280 1285 gat gtc gat act gca acc gca att gcc gag cgc ctc acc gag cgt tcc 4003 Asp Val Asp Thr Ala Thr Ala Ile Ala Glu Arg Leu Thr Glu Arg Ser                 1290 1295 1300 gga att gaa atc agc act gaa cag gtg ttg gct gca gaa acc ctc gaa 4051 Gly Ile Glu Ile Ser Thr Glu Gln Val Leu Ala Ala Glu Thr Leu Glu             1305 1310 1315 cca ctg tct gac ctg gtg cgt gaa ggc ctc gaa act gaa gtt cag ggc 4099 Pro Leu Ser Asp Leu Val Arg Glu Gly Leu Glu Thr Glu Val Gln Gly         1320 1325 1330 aac att cgt gtg ctg cgt gga cgt gca gaa ggc tcc acc aag cct gca 4147 Asn Ile Arg Val Leu Arg Gly Arg Ala Glu Gly Ser Thr Lys Pro Ala     1335 1340 1345 gtg ttc atg ttc cac cca gct ggc ggt tct tcc gtg gtc tac caa cca 4195 Val Phe Met Phe His Pro Ala Gly Gly Ser Ser Val Val Tyr Gln Pro 1350 1355 1360 1365 cta atg cgt cgt ctg cct gaa gat gtc cct gtc tat ggc gtt gag cgt 4243 Leu Met Arg Arg Leu Pro Glu Asp Val Pro Val Tyr Gly Val Glu Arg                 1370 1375 1380 ctg gaa ggc gat ctc gct gac cgc gcg gca gca tat gtt gat gac atc 4291 Leu Glu Gly Asp Leu Ala Asp Arg Ala Ala Ala Tyr Val Asp Asp Ile             1385 1390 1395 aag aag tac tcc gat ggc ttc cca gta gtt ttg ggt ggc tgg agc ttc 4339 Lys Lys Tyr Ser Asp Gly Phe Pro Val Val Leu Gly Gly Trp Ser Phe         1400 1405 1410 ggc ggt gcc gtt gcc ttc gag gtt gcc cac caa ctg gtt ggc tcc gat 4387 Gly Gly Ala Val Ala Phe Glu Val Ala His Gln Leu Val Gly Ser Asp     1415 1420 1425 gtt gag gta gct acc gtg gcg ttg ctg gat act gtg cag cct tca aac 4435 Val Glu Val Ala Thr Val Ala Leu Leu Asp Thr Val Gln Pro Ser Asn 1430 1435 1440 1445 cca gca cca gat acc gct gag gaa act cgt gca cgc tgg act cgc tac 4483 Pro Ala Pro Asp Thr Ala Glu Glu Thr Arg Ala Arg Trp Thr Arg Tyr                 1450 1455 1460 gcg gac ttc gcc aag aag acc tac ggc ctt gat ttc gag gta cct ttt 4531 Ala Asp Phe Ala Lys Lys Thr Tyr Gly Leu Asp Phe Glu Val Pro Phe             1465 1470 1475 gaa atc ttg gac acc atc ggt gaa gac gga atg ctg tcc atg atg acc 4579 Glu Ile Leu Asp Thr Ile Gly Glu Asp Gly Met Leu Ser Met Met Thr         1480 1485 1490 gac ttc ctg gcc aac acc gac gcc tcc gag cac gga ttg tcc gca ggt 4627 Asp Phe Leu Ala Asn Thr Asp Ala Ser Glu His Gly Leu Ser Ala Gly     1495 1500 1505 gtg ctt gaa cac cag cgc gct tct ttt gtg gac aac cgc atc ctg gct 4675 Val Leu Glu His Gln Arg Ala Ser Phe Val Asp Asn Arg Ile Leu Ala 1510 1515 1520 1525 aaa ctt aat ttt gca gac tgg gcc aac gtt gaa gcc cct gtc atc ctg 4723 Lys Leu Asn Phe Ala Asp Trp Ala Asn Val Glu Ala Pro Val Ile Leu                 1530 1535 1540 ttc cgc gcg gaa cgc atg cat gat gga gct atc gaa ctt gaa cca aac 4771 Phe Arg Ala Glu Arg Met His Asp Gly Ala Ile Glu Leu Glu Pro Asn             1545 1550 1555 tat gcc aag att gat caa gat gga gga tgg tcc gga att gtc aac gat 4819 Tyr Ala Lys Ile Asp Gln Asp Gly Gly Trp Ser Gly Ile Val Asn Asp         1560 1565 1570 ttg gaa att gtt cag ctg aat ggt gac cac ctg gca gtt gtc gat gaa 4867 Leu Glu Ile Val Gln Leu Asn Gly Asp His Leu Ala Val Val Asp Glu     1575 1580 1585 cca gaa atc ggc aca gtc gga gct cat ttg agt cgc cgc att gat gag 4915 Pro Glu Ile Gly Thr Val Gly Ala His Leu Ser Arg Arg Ile Asp Glu 1590 1595 1600 1605 att tct cgg aag aat tagtaacgga gagctgacgg aag 4953 Ile Ser Arg Lys Asn                 1610 <210> 14 <211> 1610 <212> PRT <213> Corynebacterium glutamicum <400> 14 Met Glu Gln Ser Gln Ser Ser Asp Gln Lys Met Thr Val Glu Gln Val   1 5 10 15 Arg Thr Trp Leu Arg Asp Trp Val Val Arg Thr Thr Gly Ile Pro Val              20 25 30 Glu Glu Val Thr Asp Asp Lys Ala Met Glu Thr Phe Gly Leu Ser Ser          35 40 45 Arg Asp Val Val Val Leu Ser Gly Glu Leu Glu Asn Leu Leu Asp Thr      50 55 60 Ser Leu Asp Ala Thr Ile Ala Tyr Glu Tyr Pro Thr Ile Arg Ser Leu  65 70 75 80 Ala Gln Arg Leu Val Glu Gly Glu Pro Arg Arg Ala His Thr Gln Arg                  85 90 95 Glu Leu Asn Phe Ser Ala Val Ser Asp Ser Pro Gly Ser His Asp Ile             100 105 110 Ala Val Val Gly Met Ala Ala Arg Tyr Pro Gly Ala Glu Ser Leu Glu         115 120 125 Asp Met Trp Lys Leu Leu Val Glu Gly Arg Asp Gly Ile Ser Asp Leu     130 135 140 Pro Ile Gly Arg Trp Ser Glu Tyr Ala Gly Asp Glu Val Met Ser Arg 145 150 155 160 Lys Met Glu Glu Phe Ser Thr Ile Gly Gly Tyr Leu Ser Asp Ile Ser                 165 170 175 Ser Phe Asp Ala Glu Phe Phe Gly Leu Ser Pro Leu Glu Ala Ala Asn             180 185 190 Met Asp Pro Gln Gln Arg Ile Leu Leu Glu Leu Thr Trp Glu Ala Leu         195 200 205 Glu Tyr Ala Arg Ile Ala Pro Asn Thr Leu Arg Gly Glu Ala Val Gly     210 215 220 Val Phe Ile Gly Ser Ser Asn Asn Asp Tyr Gly Met Met Ile Ala Ala 225 230 235 240 Asp Pro Ala Glu Ala His Pro Tyr Ala Leu Thr Gly Thr Ser Ser Ala                 245 250 255 Ile Val Ala Asn Arg Ile Asn Tyr Ala Phe Asp Phe Arg Gly Pro Ser             260 265 270 Val Asn Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Val His Gln         275 280 285 Ala Val Arg Ala Leu Arg Asn Gly Glu Ala Asp His Ala Ile Ala Gly     290 295 300 Gly Val Asn Ile Leu Ala Ser Pro Phe Val Thr Thr Ala Phe Ala Glu 305 310 315 320 Leu Gly Val Ile Ser Pro Thr Gly Lys Ile His Ala Phe Ser Asp Asp                 325 330 335 Ala Asp Gly Phe Val Arg Ser Asp Gly Ala Gly Val Val Val Leu Lys             340 345 350 Arg Val Asp Asp Ala Ile Arg Asp Gly Asp Lys Ile Ile Gly Val Ile         355 360 365 Lys Gly Ser Ala Val Asn Ser Asp Gly His Ser Asn Gly Leu Thr Ala     370 375 380 Pro Asn Pro Asp Ala Gln Val Asp Val Leu Gln Arg Ala Tyr Val Asp 385 390 395 400 Ala Gln Val Asp Pro Thr Thr Val Asp Tyr Val Glu Ala His Gly Thr                 405 410 415 Gly Thr Ile Leu Gly Asp Pro Ile Glu Ala Thr Ala Leu Gly Ala Val             420 425 430 Leu Gly Tyr Gly Arg Asp Ala Ser Thr Pro Thr Leu Leu Gly Ser Ala         435 440 445 Lys Ser Asn Phe Gly His Thr Glu Ser Ala Ala Gly Ile Ala Gly Val     450 455 460 Ile Lys Val Leu Leu Ala Leu Gln Asn Lys Thr Leu Pro Pro Thr Val 465 470 475 480 Asn Phe Ala Gly Pro Asn Arg Tyr Ile Asp Phe Asp Ala Glu Arg Leu                 485 490 495 Glu Val Val Glu Asp Pro Arg Glu Trp Pro Glu Tyr Asn Gly His Ala             500 505 510 Val Ala Gly Val Ser Ala Phe Gly Phe Gly Gly Thr Asn Ala His Val         515 520 525 Val Ile Ser Glu Tyr Asn Ala Glu Asp Tyr Glu Thr Arg Ala Pro Lys     530 535 540 Glu Ala Leu Leu Pro Asp Gln Gln Val Ala Leu Pro Val Ser Gly His 545 550 555 560 Leu Pro Ser Arg Arg Arg Gln Ala Ala Ala Asp Leu Ala Asp Phe Leu                 565 570 575 Glu Gly Arg Lys Asp Cys Asp Leu Thr Pro Val Ala Arg Ala Leu Ala             580 585 590 Gly Arg Asn His Gly Arg Ser Arg Ala Val Val Leu Ala Ser Thr Ile         595 600 605 Glu Glu Ala Val Lys Arg Leu Arg Gln Val Ala Glu Gly Lys Val Ser     610 615 620 Val Gly Ile Ser Ala Ala Asp Ser Pro Ala Ala Asn Gly Pro Val Phe 625 630 635 640 Val Tyr Ser Gly Phe Gly Ser Gln His Arg Leu Met Ile Lys Glu Leu                 645 650 655 Cys Ser Ile Ser Pro Gln Phe Arg Glu Arg Ile Glu Glu Leu Asp Glu             660 665 670 Met Val Lys Phe Glu Ser Gly Trp Ser Ile Met Lys Leu Val Leu Asp         675 680 685 Asp Glu Gln Thr Tyr Asp Thr Glu Thr Ala Gln Val Val Ile Thr Ala     690 695 700 Ile Gln Ile Ala Leu Thr Asp Leu Leu Ala Ser Phe Gly Val Lys Pro 705 710 715 720 Ala Ala Val Met Gly Met Ser Met Gly Glu Ile Ala Ala Ala Tyr Ala                 725 730 735 Ala Gly Gly Leu Ser Asp Arg Asp Thr Met Leu Ile Ala Ser His Arg             740 745 750 Ser Arg Leu Met Gly Glu Gly Glu Lys Ser Leu Ala Glu Asp Gln Leu         755 760 765 Gly Ala Met Ala Val Val Glu Phe Ala Ala Ala Asp Leu Asp Lys Phe     770 775 780 Ile Glu Glu Asn Pro Glu Tyr Lys Gly Ile Glu Pro Ala Val Tyr Ala 785 790 795 800 Gly Pro Gly Met Thr Thr Val Gly Gly Pro Arg Asp Ala Val Val Gln                 805 810 815 Phe Val Glu Lys Leu Glu Ser Glu Asp Lys Phe Ala Arg Leu Leu Asn             820 825 830 Val Lys Gly Ala Gly His Thr Ser Ala Val Glu Pro Leu Leu Gly Glu         835 840 845 Leu Ala Gly Glu Ile Ala Gly Ile Glu Pro Leu Pro Leu Gln Ile Pro     850 855 860 Leu Phe Ser Ser Val Asp Gln Gly Val Thr Tyr Pro Val Gly Ala Val 865 870 875 880 Val His Asp Ala Asp Tyr Met Leu Arg Cys Thr Arg Gln Ser Val Tyr                 885 890 895 Phe Gln Asp Ser Thr Glu Ala Ala Phe Ala Ala Gly His Asn Thr Leu             900 905 910 Val Glu Ile Ser Pro Asn Pro Val Ala Leu Met Gly Met Met Asn Thr         915 920 925 Ala Phe Thr Val Gly Lys Pro Asp Ala Gln Leu Leu Phe Ser Leu Lys     930 935 940 Arg Lys Val Pro Glu Ala Glu Ser Leu Arg Asp Leu Leu Ala Lys Leu 945 950 955 960 Tyr Val Asn Gly Ala Asn Val Asp Phe Ser Ala Leu Tyr Gly Glu Gly                 965 970 975 Glu Thr Ile Asp Pro Pro His Ile Thr Trp Lys His Gln Arg Phe Trp             980 985 990 Thr Ser Ala Arg Pro Ser Ser Gly Ala Ser Leu Asp Leu Pro Gly Phe         995 1000 1005 Arg Val Asn Leu Pro Asn Asn Thr Val Ala Phe Ser Thr Ala Ala Glu     1010 1015 1020 Leu Ala Pro Ser Ala Val Ala Ile Met Glu Ala Ala Ala Met Ala Val 1025 1030 1035 1040 Thr Pro Gly Ser Ser Val Asp Ala Val Asp Glu Arg Asp Met Leu Pro                 1045 1050 1055 Pro Ser Gly Glu Ile Thr Thr Ile Val Thr Arg Ser Leu Gly Gly Leu             1060 1065 1070 Ser Leu Ser Val Tyr Lys Ile Glu Gly Thr Thr Ser Thr Leu Val Ala         1075 1080 1085 Glu Gly Phe Ala Ala Asn Pro Gly Phe Ala Ala Ala Ser Ser Phe Asp     1090 1095 1100 Gly Pro Gly Tyr Asp Gly Phe Asn Thr Asp Tyr Ser Asp Gln Pro Asp 1105 1110 1115 1120 Pro Arg Ser Asp Leu Pro Leu Asp Ile Glu Ala Val Arg Trp Asp Pro                 1125 1130 1135 Ala Thr Glu Thr Val Glu Glu Arg Met Arg Ala Ile Val Ser Glu Ala             1140 1145 1150 Met Gly Tyr Asp Val Asp Asp Leu Pro Arg Glu Leu Pro Leu Ile Asp         1155 1160 1165 Leu Gly Leu Asp Ser Leu Met Gly Met Arg Ile Lys Asn Arg Ile Glu     1170 1175 1180 Asn Asp Phe Gln Ile Pro Pro Leu Gln Val Gln Ala Leu Arg Asp Ala 1185 1190 1195 1200 Ser Val Ala Asp Val Val Ile Met Val Glu Asn Met Val Ala Gly Arg                 1205 1210 1215 Ser Ser Glu Thr Leu Val Asp Ala Thr Pro Gln Val Pro Ala Glu Ala             1220 1225 1230 Ala Gly Glu Ala Gln Ala Ala Glu Ser Ser Ala Ser Gly Glu Asp Val         1235 1240 1245 Gln Gly Val Gly Val Ala Pro Arg Asp Ala Ser Glu Arg Met Val Phe     1250 1255 1260 Gly Thr Trp Ala Gly Leu Thr Gly Ala Ala Ala Ala Gly Val Thr Ser 1265 1270 1275 1280 Lys Leu Pro Gln Ile Asp Val Asp Thr Ala Thr Ala Ile Ala Glu Arg                 1285 1290 1295 Leu Thr Glu Arg Ser Gly Ile Glu Ile Ser Thr Glu Gln Val Leu Ala             1300 1305 1310 Ala Glu Thr Leu Glu Pro Leu Ser Asp Leu Val Arg Glu Gly Leu Glu         1315 1320 1325 Thr Glu Val Gln Gly Asn Ile Arg Val Leu Arg Gly Arg Ala Glu Gly     1330 1335 1340 Ser Thr Lys Pro Ala Val Phe Met Phe His Pro Ala Gly Gly Ser Ser 1345 1350 1355 1360 Val Val Tyr Gln Pro Leu Met Arg Arg Leu Pro Glu Asp Val Pro Val                 1365 1370 1375 Tyr Gly Val Glu Arg Leu Glu Gly Asp Leu Ala Asp Arg Ala Ala Ala             1380 1385 1390 Tyr Val Asp Asp Ile Lys Lys Tyr Ser Asp Gly Phe Pro Val Val Leu         1395 1400 1405 Gly Gly Trp Ser Phe Gly Gly Ala Val Ala Phe Glu Val Ala His Gln     1410 1415 1420 Leu Val Gly Ser Asp Val Glu Val Ala Thr Val Ala Leu Leu Asp Thr 1425 1430 1435 1440 Val Gln Pro Ser Asn Pro Ala Pro Asp Thr Ala Glu Glu Thr Arg Ala                 1445 1450 1455 Arg Trp Thr Arg Tyr Ala Asp Phe Ala Lys Lys Thr Tyr Gly Leu Asp             1460 1465 1470 Phe Glu Val Pro Phe Glu Ile Leu Asp Thr Ile Gly Glu Asp Gly Met         1475 1480 1485 Leu Ser Met Met Thr Asp Phe Leu Ala Asn Thr Asp Ala Ser Glu His     1490 1495 1500 Gly Leu Ser Ala Gly Val Leu Glu His Gln Arg Ala Ser Phe Val Asp 1505 1510 1515 1520 Asn Arg Ile Leu Ala Lys Leu Asn Phe Ala Asp Trp Ala Asn Val Glu                 1525 1530 1535 Ala Pro Val Ile Leu Phe Arg Ala Glu Arg Met His Asp Gly Ala Ile             1540 1545 1550 Glu Leu Glu Pro Asn Tyr Ala Lys Ile Asp Gln Asp Gly Gly Trp Ser         1555 1560 1565 Gly Ile Val Asn Asp Leu Glu Ile Val Gln Leu Asn Gly Asp His Leu     1570 1575 1580 Ala Val Val Asp Glu Pro Glu Ile Gly Thr Val Gly Ala His Leu Ser 1585 1590 1595 1600 Arg Arg Ile Asp Glu Ile Ser Arg Lys Asn                 1605 1610 <210> 15 <211> 540 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (517) <223> RXA01138 <400> 15 cttattcaag tttttggaaa gataattaac tatgacttta aaaacagtaa acggaacgca 60 gctgcgagac actgtcggat cgttcccttc aggtgtcacg gtg gtc acc act acc 115                                             Val Val Thr Thr Thr                                               1 5 gat ggg gaa gtg gac cac ggg ttg act gtg agt gcg ttc gtg tcc ttg 163 Asp Gly Glu Val Asp His Gly Leu Thr Val Ser Ala Phe Val Ser Leu                  10 15 20 tcg ttg gag cct gcc atg gtg ttg gtg agt atc gat aag aaa tca agc 211 Ser Leu Glu Pro Ala Met Val Leu Val Ser Ile Asp Lys Lys Ser Ser              25 30 35 gtt gtg ccg ttt ttg gag cag ggt tca cca gtt gct gtg tct gtg tta 259 Val Val Pro Phe Leu Glu Gln Gly Ser Pro Val Ala Val Ser Val Leu          40 45 50 tcg gaa gag cag agc gat ttg gcc atc aca ttt ggc cgt cat ctg gaa 307 Ser Glu Glu Gln Ser Asp Leu Ala Ile Thr Phe Gly Arg His Leu Glu      55 60 65 aac aaa ttc gac ggc gtt tcc att aag cgt tca aca aac agg gca gcg 355 Asn Lys Phe Asp Gly Val Ser Ile Lys Arg Ser Thr Asn Arg Ala Ala  70 75 80 85 gtc ttg gaa ggt gcg tca gca tgg ttg agt ggc gct gtg gtg gat aaa 403 Val Leu Glu Gly Ala Ser Ala Trp Leu Ser Gly Ala Val Val Asp Lys                  90 95 100 tac cca ggt gga gat cac ttt att atc acc att gcc gtg gaa gag tgt 451 Tyr Pro Gly Gly Asp His Phe Ile Ile Thr Ile Ala Val Glu Glu Cys             105 110 115 gct cac gac gag gag caa aag cca ctt ctt tac cac cgt ggc agg ctt 499 Ala His Asp Glu Glu Gln Lys Pro Leu Leu Tyr His Arg Gly Arg Leu         120 125 130 ttt cag tgg caa gaa gat taattctcca ccccttcatt ttc 540 Phe Gln Trp Gln Glu Asp     135 <210> 16 <211> 139 <212> PRT <213> Corynebacterium glutamicum <400> 16 Val Val Thr Thr Thr Asp Gly Glu Val Asp His Gly Leu Thr Val Ser   1 5 10 15 Ala Phe Val Ser Leu Ser Leu Glu Pro Ala Met Val Leu Val Ser Ile              20 25 30 Asp Lys Lys Ser Ser Val Val Pro Phe Leu Glu Gln Gly Ser Pro Val          35 40 45 Ala Val Ser Val Leu Ser Glu Glu Gln Ser Asp Leu Ala Ile Thr Phe      50 55 60 Gly Arg His Leu Glu Asn Lys Phe Asp Gly Val Ser Ile Lys Arg Ser  65 70 75 80 Thr Asn Arg Ala Ala Val Leu Glu Gly Ala Ser Ala Trp Leu Ser Gly                  85 90 95 Ala Val Val Asp Lys Tyr Pro Gly Gly Asp His Phe Ile Ile Thr Ile             100 105 110 Ala Val Glu Glu Cys Ala His Asp Glu Glu Gln Lys Pro Leu Leu Tyr         115 120 125 His Arg Gly Arg Leu Phe Gln Trp Gln Glu Asp     130 135 <210> 17 <211> 756 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (733) <223> RXA01980 <400> 17 aggatcgtac caaataaggc aataaactct ttttactttt cctcaacttc ctgaaaagtc 60 gccgccctag aattcactaa gtttccgata tctttaaccc atg cag atc att gat 115                                             Met Gln Ile Ile Asp                                               1 5 ctc tct cat gcg ttc gcg ccc gga caa ccc cac tac cct ggg gat cca 163 Leu Ser His Ala Phe Ala Pro Gly Gln Pro His Tyr Pro Gly Asp Pro                  10 15 20 gat caa gaa att aag acg gtc tcc acg att gaa aac gat ggc ttt tta 211 Asp Gln Glu Ile Lys Thr Val Ser Thr Ile Glu Asn Asp Gly Phe Leu              25 30 35 atg cat caa tac aga ctt gtt ggt ccc tgg gga acg cat gta gat gca 259 Met His Gln Tyr Arg Leu Val Gly Pro Trp Gly Thr His Val Asp Ala          40 45 50 cct gca cat ttc gat cca caa ggt cgg acg ctt gat cag atc cct gtg 307 Pro Ala His Phe Asp Pro Gln Gly Arg Thr Leu Asp Gln Ile Pro Val      55 60 65 gag gaa acg cat tta ccc ctt tat tgc ctg agg ttt tct cgc ccc gat 355 Glu Glu Thr His Leu Pro Leu Tyr Cys Leu Arg Phe Ser Arg Pro Asp  70 75 80 85 cta tgt act gct gct gat ata gaa gcg ttt gaa cat aca cac ggg aaa 403 Leu Cys Thr Ala Ala Asp Ile Glu Ala Phe Glu His Thr His Gly Lys                  90 95 100 atc gaa cca gga tcc ttc gtc gca ctc cac act gga tgg gaa tgg ggt 451 Ile Glu Pro Gly Ser Phe Val Ala Leu His Thr Gly Trp Glu Trp Gly             105 110 115 aaa caa ggg atc gca ccc ggc tgg tct atc gag gct tta gaa atc ctc 499 Lys Gln Gly Ile Ala Pro Gly Trp Ser Ile Glu Ala Leu Glu Ile Leu         120 125 130 cat gcc cgt gga gtc att gcc att ggc cac gat ctt ccc gat aca gat 547 His Ala Arg Gly Val Ile Ala Ile Gly His Asp Leu Pro Asp Thr Asp     135 140 145 cct tca ctg gag gca cag cgc tgg tgg ctg tgc cgt gac cat tgg cag 595 Pro Ser Leu Glu Ala Gln Arg Trp Trp Leu Cys Arg Asp His Trp Gln 150 155 160 165 att gaa aac ctc acc aat ttg gac aag gtt cct gca acg ggt gcg atg 643 Ile Glu Asn Leu Thr Asn Leu Asp Lys Val Pro Ala Thr Gly Ala Met                 170 175 180 att gct tgt cct tgg cca gtt cca aaa gat ggt gct agt ttc cca gtg 691 Ile Ala Cys Pro Trp Pro Val Pro Lys Asp Gly Ala Ser Phe Pro Val             185 190 195 cgt cca att gct ctc gtc cca gag cac cta tcc cct act cgc 733 Arg Pro Ile Ala Leu Val Pro Glu His Leu Ser Pro Thr Arg         200 205 210 taaagcgaac ggcagcacct tct 756 <210> 18 <211> 211 <212> PRT <213> Corynebacterium glutamicum <400> 18 Met Gln Ile Ile Asp Leu Ser His Ala Phe Ala Pro Gly Gln Pro His   1 5 10 15 Tyr Pro Gly Asp Pro Asp Gln Glu Ile Lys Thr Val Ser Thr Ile Glu              20 25 30 Asn Asp Gly Phe Leu Met His Gln Tyr Arg Leu Val Gly Pro Trp Gly          35 40 45 Thr His Val Asp Ala Pro Ala His Phe Asp Pro Gln Gly Arg Thr Leu      50 55 60 Asp Gln Ile Pro Val Glu Glu Thr His Leu Pro Leu Tyr Cys Leu Arg  65 70 75 80 Phe Ser Arg Pro Asp Leu Cys Thr Ala Ala Asp Ile Glu Ala Phe Glu                  85 90 95 His Thr His Gly Lys Ile Glu Pro Gly Ser Phe Val Ala Leu His Thr             100 105 110 Gly Trp Glu Trp Gly Lys Gln Gly Ile Ala Pro Gly Trp Ser Ile Glu         115 120 125 Ala Leu Glu Ile Leu His Ala Arg Gly Val Ile Ala Ile Gly His Asp     130 135 140 Leu Pro Asp Thr Asp Pro Ser Leu Glu Ala Gln Arg Trp Trp Leu Cys 145 150 155 160 Arg Asp His Trp Gln Ile Glu Asn Leu Thr Asn Leu Asp Lys Val Pro                 165 170 175 Ala Thr Gly Ala Met Ile Ala Cys Pro Trp Pro Val Pro Lys Asp Gly             180 185 190 Ala Ser Phe Pro Val Arg Pro Ile Ala Leu Val Pro Glu His Leu Ser         195 200 205 Pro Thr Arg     210 <210> 19 <211> 1830 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (1807) <223> RXN01007 <400> 19 tctgaaccaa tataccgatc agtctaaaag tgtgttaagt tctggaacat aaattagctg 60 acacgtaaag taacttaaag attcactgga ggtaagccta gtg ttt aaa aag cac 115                                             Val Phe Lys Lys His                                               1 5 aga cac ggt ctc ggc tcc ccc gaa acc aaa cca cgc tca ata acc cgc 163 Arg His Gly Leu Gly Ser Pro Glu Thr Lys Pro Arg Ser Ile Thr Arg                  10 15 20 cgg ttt ttc acc gcg gcc gcc gct acg ctg gca gga ttg gca gtc ctg 211 Arg Phe Phe Thr Ala Ala Ala Ala Thr Leu Ala Gly Leu Ala Val Leu              25 30 35 tcc ggc tgc aca gca caa ccc tca caa gca gaa gac aac acg ctc act 259 Ser Gly Cys Thr Ala Gln Pro Ser Gln Ala Glu Asp Asn Thr Leu Thr          40 45 50 tac tta gag cca cag ttc ttc cgc acc ctg tac cca cca tca gcg ggc 307 Tyr Leu Glu Pro Gln Phe Phe Arg Thr Leu Tyr Pro Pro Ser Ala Gly      55 60 65 ttt tac ccc aac ggc agt gtg gtg aac aac att gca gac cgc ttg ctc 355 Phe Tyr Pro Asn Gly Ser Val Val Asn Asn Ile Ala Asp Arg Leu Leu  70 75 80 85 tac cag gat cct gaa acc ttg gaa ctc aag ccg tgg atc gcc acc gaa 403 Tyr Gln Asp Pro Glu Thr Leu Glu Leu Lys Pro Trp Ile Ala Thr Glu                  90 95 100 ctc cca gaa gta aac gaa gac gcc acg gaa ttt acc ttc aac atc cgc 451 Leu Pro Glu Val Asn Glu Asp Ala Thr Glu Phe Thr Phe Asn Ile Arg             105 110 115 acc gat gtc acc tac tcc gat ggc acc ccg ctg acg gct gaa aac gtg 499 Thr Asp Val Thr Tyr Ser Asp Gly Thr Pro Leu Thr Ala Glu Asn Val         120 125 130 gtg aaa aac ttc gat ctc tat ggc ctc ggc gat caa gat cga cgc ctc 547 Val Lys Asn Phe Asp Leu Tyr Gly Leu Gly Asp Gln Asp Arg Arg Leu     135 140 145 acc atc tct gag cag atc acc aac tac gac cac ggc gaa gta gta gat 595 Thr Ile Ser Glu Gln Ile Thr Asn Tyr Asp His Gly Glu Val Val Asp 150 155 160 165 gag gac acc gtc cga ttc cac ttc tct gag cct gca cct ggt ttt gct 643 Glu Asp Thr Val Arg Phe His Phe Ser Glu Pro Ala Pro Gly Phe Ala                 170 175 180 cag gcc acc agc tcc ttc aac gct ggc ctt tat gcc gat tcc acc ttg 691 Gln Ala Thr Ser Ser Phe Asn Ala Gly Leu Tyr Ala Asp Ser Thr Leu             185 190 195 gag ttc gcc aat gag gat ttc gcg cca ggc aac gcc caa aac gtc atc 739 Glu Phe Ala Asn Glu Asp Phe Ala Pro Gly Asn Ala Gln Asn Val Ile         200 205 210 ggc tcc ggt cct ttc gtg atc acc gat gaa acc cta ggc acc aac ctc 787 Gly Ser Gly Pro Phe Val Ile Thr Asp Glu Thr Leu Gly Thr Asn Leu     215 220 225 acc ttg act gcg cgt gag gat tac gat tgg gca cca cca tca cgc gaa 835 Thr Leu Thr Ala Arg Glu Asp Tyr Asp Trp Ala Pro Pro Ser Arg Glu 230 235 240 245 cat caa ggt cgc gcg aag ctt gac gcc gtc aat tat gtc ctc gcg ggt 883 His Gln Gly Arg Ala Lys Leu Asp Ala Val Asn Tyr Val Leu Ala Gly                 250 255 260 gaa gaa tcc gtc cgc atc gga gcc atc gtt gct ggc caa ggt gat atc 931 Glu Glu Ser Val Arg Ile Gly Ala Ile Val Ala Gly Gln Gly Asp Ile             265 270 275 gcc cgc cag atc gaa gcg cca gtg gag gca cac ctg aag gat gca ggc 979 Ala Arg Gln Ile Glu Ala Pro Val Glu Ala His Leu Lys Asp Ala Gly         280 285 290 atc ccg atc atc tcc gca gcc acc aac ggt gtg aac aac agc ttc aac 1027 Ile Pro Ile Ile Ser Ala Ala Thr Asn Gly Val Asn Asn Ser Phe Asn     295 300 305 ttc cgc ttc aaa aac gag ctg ctc tca gac atc cgt gtt cgc caa gct 1075 Phe Arg Phe Lys Asn Glu Leu Leu Ser Asp Ile Arg Val Arg Gln Ala 310 315 320 325 ctg atc cac gcg atc gac cgc gaa aag atc atg cgt gtg ctg ttt agt 1123 Leu Ile His Ala Ile Asp Arg Glu Lys Ile Met Arg Val Leu Phe Ser                 330 335 340 gat tcc tat ccg ctg gca act tct gtg ctt gcg caa aat gca ctg ggc 1171 Asp Ser Tyr Pro Leu Ala Thr Ser Val Leu Ala Gln Asn Ala Leu Gly             345 350 355 tac aaa gaa caa gta gat gcc tat gtc tac gac cta gac aaa gca aca 1219 Tyr Lys Glu Gln Val Asp Ala Tyr Val Tyr Asp Leu Asp Lys Ala Thr         360 365 370 gct ctg ctt gac gaa gcc ggc tgg acc ctt gat agc gac ggc atg cgt 1267 Ala Leu Leu Asp Glu Ala Gly Trp Thr Leu Asp Ser Asp Gly Met Arg     375 380 385 cgc aag gac ggt gaa ctt cta gag ctc acc ttc aac gaa gcc ctc cca 1315 Arg Lys Asp Gly Glu Leu Leu Glu Leu Thr Phe Asn Glu Ala Leu Pro 390 395 400 405 cag cct cgt tca cgc gaa gtt gtc acc atg gtc caa gaa cag ctc ggt 1363 Gln Pro Arg Ser Arg Glu Val Val Thr Met Val Gln Glu Gln Leu Gly                 410 415 420 gat ctg ggc atc aag gtc aac ctc aac cca ggt gac caa gca gcc cag 1411 Asp Leu Gly Ile Lys Val Asn Leu Asn Pro Gly Asp Gln Ala Ala Gln             425 430 435 gac gct gac tcc aag gat ctc aac aag atc cag gtt cgc cac acc atg 1459 Asp Ala Asp Ser Lys Asp Leu Asn Lys Ile Gln Val Arg His Thr Met         440 445 450 gtg ggt cgc gca gac tat gac gtg ctg aaa tcc cag ctg tac tcc acc 1507 Val Gly Arg Ala Asp Tyr Asp Val Leu Lys Ser Gln Leu Tyr Ser Thr     455 460 465 aac cgc aac gag ctg ttg aac atg acc gtg gaa ggg gag acc gcc gat 1555 Asn Arg Asn Glu Leu Leu Asn Met Thr Val Glu Gly Glu Thr Ala Asp 470 475 480 485 att ggc gat cct cat ttg gag gaa ctc ctc atg gct att gca tcc agc 1603 Ile Gly Asp Pro His Leu Glu Glu Leu Leu Met Ala Ile Ala Ser Ser                 490 495 500 cca cgc gaa gag gac cgt gca gca gca tct gcc gca gca cag gat tac 1651 Pro Arg Glu Glu Asp Arg Ala Ala Ala Ser Ala Ala Ala Gln Asp Tyr             505 510 515 atc acc gag cag gca tat gtt ctt cca ctg ttt gaa gag cca gtt gtc 1699 Ile Thr Glu Gln Ala Tyr Val Leu Pro Leu Phe Glu Glu Pro Val Val         520 525 530 tac ggc gtg cag cct tac gtg aag ggc ttt agc ccc gaa gtg atc ggc 1747 Tyr Gly Val Gln Pro Tyr Val Lys Gly Phe Ser Pro Glu Val Ile Gly     535 540 545 cgc ccc agc ttc tat gag acc tac att gac cat tcc agc gac cat tcc 1795 Arg Pro Ser Phe Tyr Glu Thr Tyr Ile Asp His Ser Ser Asp His Ser 550 555 560 565 agt gag gag gac taaatgacta cctcgcagat tct 1830 Ser Glu Glu Asp <210> 20 <211> 569 <212> PRT <213> Corynebacterium glutamicum <400> 20 Val Phe Lys Lys His Arg His Gly Leu Gly Ser Pro Glu Thr Lys Pro   1 5 10 15 Arg Ser Ile Thr Arg Arg Phe Phe Thr Ala Ala Ala Thr Leu Ala              20 25 30 Gly Leu Ala Val Leu Ser Gly Cys Thr Ala Gln Pro Ser Gln Ala Glu          35 40 45 Asp Asn Thr Leu Thr Tyr Leu Glu Pro Gln Phe Phe Arg Thr Leu Tyr      50 55 60 Pro Pro Ser Ala Gly Phe Tyr Pro Asn Gly Ser Val Val Asn Asn Ile  65 70 75 80 Ala Asp Arg Leu Leu Tyr Gln Asp Pro Glu Thr Leu Glu Leu Lys Pro                  85 90 95 Trp Ile Ala Thr Glu Leu Pro Glu Val Asn Glu Asp Ala Thr Glu Phe             100 105 110 Thr Phe Asn Ile Arg Thr Asp Val Thr Tyr Ser Asp Gly Thr Pro Leu         115 120 125 Thr Ala Glu Asn Val Val Lys Asn Phe Asp Leu Tyr Gly Leu Gly Asp     130 135 140 Gln Asp Arg Arg Leu Thr Ile Ser Glu Gln Ile Thr Asn Tyr Asp His 145 150 155 160 Gly Glu Val Val Asp Glu Asp Thr Val Arg Phe His Phe Ser Glu Pro                 165 170 175 Ala Pro Gly Phe Ala Gln Ala Thr Ser Ser Phe Asn Ala Gly Leu Tyr             180 185 190 Ala Asp Ser Thr Leu Glu Phe Ala Asn Glu Asp Phe Ala Pro Gly Asn         195 200 205 Ala Gln Asn Val Ile Gly Ser Gly Pro Phe Val Ile Thr Asp Glu Thr     210 215 220 Leu Gly Thr Asn Leu Thr Leu Thr Ala Arg Glu Asp Tyr Asp Trp Ala 225 230 235 240 Pro Pro Ser Arg Glu His Gln Gly Arg Ala Lys Leu Asp Ala Val Asn                 245 250 255 Tyr Val Leu Ala Gly Glu Glu Ser Val Arg Ile Gly Ala Ile Val Ala             260 265 270 Gly Gln Gly Asp Ile Ala Arg Gln Ile Glu Ala Pro Val Glu Ala His         275 280 285 Leu Lys Asp Ala Gly Ile Pro Ile Ile Ser Ala Ala Thr Asn Gly Val     290 295 300 Asn Asn Ser Phe Asn Phe Arg Phe Lys Asn Glu Leu Leu Ser Asp Ile 305 310 315 320 Arg Val Arg Gln Ala Leu Ile His Ala Ile Asp Arg Glu Lys Ile Met                 325 330 335 Arg Val Leu Phe Ser Asp Ser Tyr Pro Leu Ala Thr Ser Val Leu Ala             340 345 350 Gln Asn Ala Leu Gly Tyr Lys Glu Gln Val Asp Ala Tyr Val Tyr Asp         355 360 365 Leu Asp Lys Ala Thr Ala Leu Leu Asp Glu Ala Gly Trp Thr Leu Asp     370 375 380 Ser Asp Gly Met Arg Arg Lys Asp Gly Glu Leu Leu Glu Leu Thr Phe 385 390 395 400 Asn Glu Ala Leu Pro Gln Pro Arg Ser Arg Glu Val Val Thr Met Val                 405 410 415 Gln Glu Gln Leu Gly Asp Leu Gly Ile Lys Val Asn Leu Asn Pro Gly             420 425 430 Asp Gln Ala Ala Gln Asp Ala Asp Ser Lys Asp Leu Asn Lys Ile Gln         435 440 445 Val Arg His Thr Met Val Gly Arg Ala Asp Tyr Asp Val Leu Lys Ser     450 455 460 Gln Leu Tyr Ser Thr Asn Arg Asn Glu Leu Leu Asn Met Thr Val Glu 465 470 475 480 Gly Glu Thr Ala Asp Ile Gly Asp Pro His Leu Glu Glu Leu Leu Met                 485 490 495 Ala Ile Ala Ser Ser Pro Arg Glu Glu Asp Arg Ala Ala Ala Ser Ala             500 505 510 Ala Ala Gln Asp Tyr Ile Thr Glu Gln Ala Tyr Val Leu Pro Leu Phe         515 520 525 Glu Glu Pro Val Val Tyr Gly Val Gln Pro Tyr Val Lys Gly Phe Ser     530 535 540 Pro Glu Val Ile Gly Arg Pro Ser Phe Tyr Glu Thr Tyr Ile Asp His 545 550 555 560 Ser Ser Asp His Ser Ser Glu Glu Asp                 565 <210> 21 <211> 858 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (835) <223> RXN00784 <400> 21 gtcacatcag ttatcgcgcg gaatagttag cgggcgcatg tggttgggat atatgaataa 60 atctattcca actacgcgta aaacgaggac gtttaaagct atg tct att gaa ttc 115                                             Met Ser Ile Glu Phe                                               1 5 tcc gca cca gca aaa atg aaa atc gaa gtg tgg agc gac atc atg tgc 163 Ser Ala Pro Ala Lys Met Lys Ile Glu Val Trp Ser Asp Ile Met Cys                  10 15 20 ccc ttc tgc tac atc ggc aaa aag cgc ctc gac gac gcc cta agt acc 211 Pro Phe Cys Tyr Ile Gly Lys Lys Arg Leu Asp Asp Ala Leu Ser Thr              25 30 35 ttt gac cag gcc gga cgc atc gaa gtg gaa tac aag agc ttc gaa ctc 259 Phe Asp Gln Ala Gly Arg Ile Glu Val Glu Tyr Lys Ser Phe Glu Leu          40 45 50 atg cca ggc cta gaa acc cac cca ctg cgt tcc gac gtt gaa tac ctc 307 Met Pro Gly Leu Glu Thr His Pro Leu Arg Ser Asp Val Glu Tyr Leu      55 60 65 gcc gac gcc aag ggc atg agc ctc gag cag gcc cgc caa atg aac ggc 355 Ala Asp Ala Lys Gly Met Ser Leu Glu Gln Ala Arg Gln Met Asn Gly  70 75 80 85 caa gtc caa gca atg gca caa gcc acc gga ctt gaa atg aat cct gac 403 Gln Val Gln Ala Met Ala Gln Ala Thr Gly Leu Glu Met Asn Pro Asp                  90 95 100 gaa acc atc gcg gcc aac acc atc aac gcg cac cgc ctt acc cac ttc 451 Glu Thr Ile Ala Ala Asn Thr Ile Asn Ala His Arg Leu Thr His Phe             105 110 115 gcg aaa gcc cac ggc aag caa caa gaa gtg gcg cag gaa ctc ttc aag 499 Ala Lys Ala His Gly Lys Gln Gln Glu Val Ala Gln Glu Leu Phe Lys         120 125 130 gct cac ttc gta gac ggc aag aac gtt gat gac ctc gat gtg ctg gtc 547 Ala His Phe Val Asp Gly Lys Asn Val Asp Asp Leu Asp Val Leu Val     135 140 145 tcc att gct gca gag gtt ggt ctc gat gcc agt gca gcc cgc gaa gct 595 Ser Ile Ala Ala Glu Val Gly Leu Asp Ala Ser Ala Ala Arg Glu Ala 150 155 160 165 ctc gaa tcc gac gtg tac acc aac gaa gtc caa caa gac gtc cac gaa 643 Leu Glu Ser Asp Val Tyr Thr Asn Glu Val Gln Gln Asp Val His Glu                 170 175 180 gcc cgc caa ctc ggc gtc caa ggt gtg ccc ttc ttt gta ttc gac cgc 691 Ala Arg Gln Leu Gly Val Gln Gly Val Pro Phe Phe Val Phe Asp Arg             185 190 195 aaa tac gcc atc aac ggc gcc caa caa gaa gaa gta ttc acc ggc acc 739 Lys Tyr Ala Ile Asn Gly Ala Gln Gln Glu Glu Val Phe Thr Gly Thr         200 205 210 gta gaa aaa gcc ttc gaa gag tgg gca gcc gaa aac cca gtc agc cca 787 Val Glu Lys Ala Phe Glu Glu Trp Ala Ala Glu Asn Pro Val Ser Pro     215 220 225 ttt gag gtc att gac ggc caa agc tgc tcc gtc gac ggc acc tgc aac 835 Phe Glu Val Ile Asp Gly Gln Ser Cys Ser Val Asp Gly Thr Cys Asn 230 235 240 245 taacttttgg gacctatgtg cgt 858 <210> 22 <211> 245 <212> PRT <213> Corynebacterium glutamicum <400> 22 Met Ser Ile Glu Phe Ser Ala Pro Ala Lys Met Lys Ile Glu Val Trp   1 5 10 15 Ser Asp Ile Met Cys Pro Phe Cys Tyr Ile Gly Lys Lys Arg Leu Asp              20 25 30 Asp Ala Leu Ser Thr Phe Asp Gln Ala Gly Arg Ile Glu Val Glu Tyr          35 40 45 Lys Ser Phe Glu Leu Met Pro Gly Leu Glu Thr His Pro Leu Arg Ser      50 55 60 Asp Val Glu Tyr Leu Ala Asp Ala Lys Gly Met Ser Leu Glu Gln Ala  65 70 75 80 Arg Gln Met Asn Gly Gln Val Gln Ala Met Ala Gln Ala Thr Gly Leu                  85 90 95 Glu Met Asn Pro Asp Glu Thr Ile Ala Ala Asn Thr Ile Asn Ala His             100 105 110 Arg Leu Thr His Phe Ala Lys Ala His Gly Lys Gln Gln Glu Val Ala         115 120 125 Gln Glu Leu Phe Lys Ala His Phe Val Asp Gly Lys Asn Val Asp Asp     130 135 140 Leu Asp Val Leu Val Ser Ile Ala Ala Glu Val Gly Leu Asp Ala Ser 145 150 155 160 Ala Ala Arg Glu Ala Leu Glu Ser Asp Val Tyr Thr Asn Glu Val Gln                 165 170 175 Gln Asp Val His Glu Ala Arg Gln Leu Gly Val Gln Gly Val Pro Phe             180 185 190 Phe Val Phe Asp Arg Lys Tyr Ala Ile Asn Gly Ala Gln Gln Glu Glu         195 200 205 Val Phe Thr Gly Thr Val Glu Lys Ala Phe Glu Glu Trp Ala Ala Glu     210 215 220 Asn Pro Val Ser Pro Phe Glu Val Ile Asp Gly Gln Ser Cys Ser Val 225 230 235 240 Asp Gly Thr Cys Asn                 245 <210> 23 <211> 1896 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1873) <223> RXA02335 <400> 23 tggttgagtt cttcggggtt gagtgtgcaa gaatattcac tattggtcag gcaactatgt 60 gtctacccac tgagtcatca atttaaatca ggagttatta gtg tca gtc gag act 115                                             Val Ser Val Glu Thr                                               1 5 agg aag atc acc aag gtt ctt gtc gct aac cgt ggt gag att gca atc 163 Arg Lys Ile Thr Lys Val Leu Val Ala Asn Arg Gly Glu Ile Ala Ile                  10 15 20 cgc gtg ttc cgt gca gct cga gat gaa ggc atg gga tct gtc gcc gtc 211 Arg Val Phe Arg Ala Ala Arg Asp Glu Gly Met Gly Ser Val Ala Val              25 30 35 tac gca gag cca gat gca gat gca cca ttc gtg tca tat gca gac gag 259 Tyr Ala Glu Pro Asp Ala Asp Ala Pro Phe Val Ser Tyr Ala Asp Glu          40 45 50 gct ttt gcc ctc ggt ggc caa aca tcc gct gag tcc tac ctt gtc att 307 Ala Phe Ala Leu Gly Gly Gln Thr Ser Ala Glu Ser Tyr Leu Val Ile      55 60 65 gac aag atc atc gat gcg gcc cgc aag tcc ggc gcc gac gcc atc cac 355 Asp Lys Ile Ile Asp Ala Ala Arg Lys Ser Gly Ala Asp Ala Ile His  70 75 80 85 ccc ggc tac ggc ttc ctc gca gaa aac gct gac ttc gca gaa gca gtc 403 Pro Gly Tyr Gly Phe Leu Ala Glu Asn Ala Asp Phe Ala Glu Ala Val                  90 95 100 atc aac gaa ggc ctg atc tgg att gga cct tca cct gag tcc atc cgc 451 Ile Asn Glu Gly Leu Ile Trp Ile Gly Pro Ser Pro Glu Ser Ile Arg             105 110 115 tcc ctc ggc gac aag gtc acc gct cgc cac atc gca gat acc gcc aag 499 Ser Leu Gly Asp Lys Val Thr Ala Arg His Ile Ala Asp Thr Ala Lys         120 125 130 gct cca atg gct cct ggc acc aag gaa cca gta aaa gac gca gca gaa 547 Ala Pro Met Ala Pro Gly Thr Lys Glu Pro Val Lys Asp Ala Ala Glu     135 140 145 gtt gtg gct ttc gct gaa gaa ttc ggt ctc cca atc gcc atc aag gca 595 Val Val Ala Phe Ala Glu Glu Phe Gly Leu Pro Ile Ala Ile Lys Ala 150 155 160 165 gct ttc ggt ggc ggc gga cgt ggc atg aag gtt gcc tac aag atg gaa 643 Ala Phe Gly Gly Gly Gly Arg Gly Met Lys Val Ala Tyr Lys Met Glu                 170 175 180 gaa gtc gct gac ctc ttc gag tcc gca acc cgt gaa gca acc gca gcg 691 Glu Val Ala Asp Leu Phe Glu Ser Ala Thr Arg Glu Ala Thr Ala Ala             185 190 195 ttc ggc cgc ggc gag tgc ttc gtg gag cgc tac ctg gac aag gca cgc 739 Phe Gly Arg Gly Glu Cys Phe Val Glu Arg Tyr Leu Asp Lys Ala Arg         200 205 210 cac gtt gag gct cag gtc atc gcc gat aag cac ggc aac gtt gtt gtc 787 His Val Glu Ala Gln Val Ile Ala Asp Lys His Gly Asn Val Val Val     215 220 225 gcc gga acc cgt gac tgc tcc ctg cag cgc cgt ttc cag aag ctc gtc 835 Ala Gly Thr Arg Asp Cys Ser Leu Gln Arg Arg Phe Gln Lys Leu Val 230 235 240 245 gaa gaa gca cca gca cca ttc ctc acc gat gac cag cgc gag cgt ctc 883 Glu Glu Ala Pro Ala Pro Phe Leu Thr Asp Asp Gln Arg Glu Arg Leu                 250 255 260 cac tcc tcc gcg aag gct atc tgt aag gaa gct ggc tac tac ggt gca 931 His Ser Ser Ala Lys Ala Ile Cys Lys Glu Ala Gly Tyr Tyr Gly Ala             265 270 275 ggc acc gtt gag tac ctc gtt ggc tcc gac ggc ctg atc tcc ttc ctc 979 Gly Thr Val Glu Tyr Leu Val Gly Ser Asp Gly Leu Ile Ser Phe Leu         280 285 290 gag gtc aac acc cgc ctc cag gtg gaa cac cca gtc acc gaa gag acc 1027 Glu Val Asn Thr Arg Leu Gln Val Glu His Pro Val Thr Glu Glu Thr     295 300 305 acc ggc atc gac ctg gtc cgc gaa atg ttc cgc atc gca gaa ggc cac 1075 Thr Gly Ile Asp Leu Val Arg Glu Met Phe Arg Ile Ala Glu Gly His 310 315 320 325 gag ctc tcc atc aag gaa gat cca gct cca cgc ggc cac gca ttc gag 1123 Glu Leu Ser Ile Lys Glu Asp Pro Ala Pro Arg Gly His Ala Phe Glu                 330 335 340 ttc cgc atc aac ggc gaa gac gct ggc tcc aac ttc atg cct gca cca 1171 Phe Arg Ile Asn Gly Glu Asp Ala Gly Ser Asn Phe Met Pro Ala Pro             345 350 355 ggc aag atc acc agc tac cgc gag cca cag ggc cca ggc gtc cgc atg 1219 Gly Lys Ile Thr Ser Tyr Arg Glu Pro Gln Gly Pro Gly Val Arg Met         360 365 370 gac tcc ggt gtc gtt gaa ggt tcc gaa atc tcc gga cag ttc gac tcc 1267 Asp Ser Gly Val Val Glu Gly Ser Glu Ile Ser Gly Gln Phe Asp Ser     375 380 385 atg ctg gca aag ctg atc gtt tgg ggc gac acc cgc gag cag gct ctc 1315 Met Leu Ala Lys Leu Ile Val Trp Gly Asp Thr Arg Glu Gln Ala Leu 390 395 400 405 cag cgc tcc cgc cgt gca ctt gca gag tac gtt gtc gag ggc atg cca 1363 Gln Arg Ser Arg Arg Ala Leu Ala Glu Tyr Val Val Glu Gly Met Pro                 410 415 420 acc gtt atc cca ttc cac cag cac atc gtg gaa aac cca gca ttc gtg 1411 Thr Val Ile Pro Phe His Gln His Ile Val Glu Asn Pro Ala Phe Val             425 430 435 ggc aac gac gaa ggc ttc gag atc tac acc aag tgg atc gaa gag gtt 1459 Gly Asn Asp Glu Gly Phe Glu Ile Tyr Thr Lys Trp Ile Glu Glu Val         440 445 450 tgg gat aac cca atc gca cct tac gtt gac gct tcc gag ctc gac gaa 1507 Trp Asp Asn Pro Ile Ala Pro Tyr Val Asp Ala Ser Glu Leu Asp Glu     455 460 465 gat gag gac aag acc cca gca cag aag gtt gtt gtg gag atc aac ggc 1555 Asp Glu Asp Lys Thr Pro Ala Gln Lys Val Val Val Glu Ile Asn Gly 470 475 480 485 cgt cgc gtt gag gtt gca ctc cca ggc gat ctg gca ctc ggt ggc acc 1603 Arg Arg Val Glu Val Ala Leu Pro Gly Asp Leu Ala Leu Gly Gly Thr                 490 495 500 gct ggt cct aag aag aag gcc aag aag cgt cgc gca ggt ggt gca aag 1651 Ala Gly Pro Lys Lys Lys Ala Lys Lys Arg Arg Ala Gly Gly Ala Lys             505 510 515 gct ggc gta tcc ggc gat gca gtg gca gct cca atg cag ggc act gtc 1699 Ala Gly Val Ser Gly Asp Ala Val Ala Ala Pro Met Gln Gly Thr Val         520 525 530 atc aag gtc aac gtc gaa gaa ggc gct gaa gtc aac gaa ggc gac acc 1747 Ile Lys Val Asn Val Glu Glu Gly Ala Glu Val Asn Glu Gly Asp Thr     535 540 545 gtt gtt gtc ctc gag gct atg aag atg gaa aac cct gtg aag gct cat 1795 Val Val Val Leu Glu Ala Met Lys Met Glu Asn Pro Val Lys Ala His 550 555 560 565 aag tcc gga acc gta acc ggc ctt act gtc gct gca ggc gag ggt gtc 1843 Lys Ser Gly Thr Val Thr Gly Leu Thr Val Ala Ala Gly Glu Gly Val                 570 575 580 aac aag ggc gtt gtt ctc ctc gag atc aag taagttcttg gattcctgtt 1893 Asn Lys Gly Val Val Leu Leu Glu Ile Lys             585 590 agt 1896 <210> 24 <211> 591 <212> PRT <213> Corynebacterium glutamicum <400> 24 Val Ser Val Glu Thr Arg Lys Ile Thr Lys Val Leu Val Ala Asn Arg   1 5 10 15 Gly Glu Ile Ala Ile Arg Val Phe Arg Ala Ala Arg Asp Glu Gly Met              20 25 30 Gly Ser Val Ala Val Tyr Ala Glu Pro Asp Ala Asp Ala Pro Phe Val          35 40 45 Ser Tyr Ala Asp Glu Ala Phe Ala Leu Gly Gly Gln Thr Ser Ala Glu      50 55 60 Ser Tyr Leu Val Ile Asp Lys Ile Ile Asp Ala Ala Arg Lys Ser Gly  65 70 75 80 Ala Asp Ala Ile His Pro Gly Tyr Gly Phe Leu Ala Glu Asn Ala Asp                  85 90 95 Phe Ala Glu Ala Val Ile Asn Glu Gly Leu Ile Trp Ile Gly Pro Ser             100 105 110 Pro Glu Ser Ile Arg Ser Leu Gly Asp Lys Val Thr Ala Arg His Ile         115 120 125 Ala Asp Thr Ala Lys Ala Pro Met Ala Pro Gly Thr Lys Glu Pro Val     130 135 140 Lys Asp Ala Ala Glu Val Val Ala Phe Ala Glu Glu Phe Gly Leu Pro 145 150 155 160 Ile Ala Ile Lys Ala Ala Phe Gly Gly Gly Gly Arg Gly Met Lys Val                 165 170 175 Ala Tyr Lys Met Glu Glu Val Ala Asp Leu Phe Glu Ser Ala Thr Arg             180 185 190 Glu Ala Thr Ala Ala Phe Gly Arg Gly Glu Cys Phe Val Glu Arg Tyr         195 200 205 Leu Asp Lys Ala Arg His Val Glu Ala Gln Val Ile Ala Asp Lys His     210 215 220 Gly Asn Val Val Val Ala Gly Thr Arg Asp Cys Ser Leu Gln Arg Arg 225 230 235 240 Phe Gln Lys Leu Val Glu Glu Ala Pro Ala Pro Phe Leu Thr Asp Asp                 245 250 255 Gln Arg Glu Arg Leu His Ser Ser Ala Lys Ala Ile Cys Lys Glu Ala             260 265 270 Gly Tyr Tyr Gly Ala Gly Thr Val Glu Tyr Leu Val Gly Ser Asp Gly         275 280 285 Leu Ile Ser Phe Leu Glu Val Asn Thr Arg Leu Gln Val Glu His Pro     290 295 300 Val Thr Glu Glu Thr Thr Gly Ile Asp Leu Val Arg Glu Met Phe Arg 305 310 315 320 Ile Ala Glu Gly His Glu Leu Ser Ile Lys Glu Asp Pro Ala Pro Arg                 325 330 335 Gly His Ala Phe Glu Phe Arg Ile Asn Gly Glu Asp Ala Gly Ser Asn             340 345 350 Phe Met Pro Ala Pro Gly Lys Ile Thr Ser Tyr Arg Glu Pro Gln Gly         355 360 365 Pro Gly Val Arg Met Asp Ser Gly Val Val Glu Gly Ser Glu Ile Ser     370 375 380 Gly Gln Phe Asp Ser Met Leu Ala Lys Leu Ile Val Trp Gly Asp Thr 385 390 395 400 Arg Glu Gln Ala Leu Gln Arg Ser Arg Arg Ala Leu Ala Glu Tyr Val                 405 410 415 Val Glu Gly Met Pro Thr Val Ile Pro Phe His Gln His Ile Val Glu             420 425 430 Asn Pro Ala Phe Val Gly Asn Asp Glu Gly Phe Glu Ile Tyr Thr Lys         435 440 445 Trp Ile Glu Glu Val Trp Asp Asn Pro Ile Ala Pro Tyr Val Asp Ala     450 455 460 Ser Glu Leu Asp Glu Asp Glu Asp Lys Thr Pro Ala Gln Lys Val Val 465 470 475 480 Val Glu Ile Asn Gly Arg Arg Val Glu Val Ala Leu Pro Gly Asp Leu                 485 490 495 Ala Leu Gly Gly Thr Ala Gly Pro Lys Lys Lys Ala Lys Lys Arg Arg             500 505 510 Ala Gly Gly Ala Lys Ala Gly Val Ser Gly Asp Ala Val Ala Ala Pro         515 520 525 Met Gln Gly Thr Val Ile Lys Val Asn Val Glu Glu Gly Ala Glu Val     530 535 540 Asn Glu Gly Asp Thr Val Val Val Leu Glu Ala Met Lys Met Glu Asn 545 550 555 560 Pro Val Lys Ala His Lys Ser Gly Thr Val Thr Gly Leu Thr Val Ala                 565 570 575 Ala Gly Glu Gly Val Asn Lys Gly Val Val Leu Leu Glu Ile Lys             580 585 590 <210> 25 <211> 1575 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1552) <223> RXA02173 <400> 25 ctaaattggg cttagatctt ccgcctctaa ataggtatgc agagacattc gaattaatta 60 acaaagccat ttttcggccg tggagaagcg ttttccgact atg gtg tgg ggc atg 115                                             Met Val Trp Gly Met                                               1 5 gaa cac act tca gca ttg acg ctc ata gac tcg gtt ttg gac cct gac 163 Glu His Thr Ser Ala Leu Thr Leu Ile Asp Ser Val Leu Asp Pro Asp                  10 15 20 agc ttc att tct tgg aat gaa act ccc caa tat gac aac ctc aat caa 211 Ser Phe Ile Ser Trp Asn Glu Thr Pro Gln Tyr Asp Asn Leu Asn Gln              25 30 35 ggc tat gca gag acc ttg gag cgg gct cga agc aag gcc aaa tgc gat 259 Gly Tyr Ala Glu Thr Leu Glu Arg Ala Arg Ser Lys Ala Lys Cys Asp          40 45 50 gaa tcg gta att act gga gaa ggc acc gtg gag ggc att ccg gta gcc 307 Glu Ser Val Ile Thr Gly Glu Gly Thr Val Glu Gly Ile Pro Val Ala      55 60 65 gtt att ttg tcc gat ttt tcc ttc ctc ggc ggt tct ttg ggc acg gtc 355 Val Ile Leu Ser Asp Phe Ser Phe Leu Gly Gly Ser Leu Gly Thr Val  70 75 80 85 gcg tcg gtg cgc atc atg aag gcg att cac cgc gcc aca gag ctg aaa 403 Ala Ser Val Arg Ile Met Lys Ala Ile His Arg Ala Thr Glu Leu Lys                  90 95 100 ctc cca ctg ctg gtc tcc cct gct tcc ggt ggt gcg cgc atg cag gaa 451 Leu Pro Leu Leu Val Ser Pro Ala Ser Gly Gly Ala Arg Met Gln Glu             105 110 115 gac aat cga gct ttt gtc atg atg gtg tcc ata acc gcg gct gtg cag 499 Asp Asn Arg Ala Phe Val Met Met Val Ser Ile Thr Ala Ala Val Gln         120 125 130 cgt cac cgc gag gcg cat ttg ccg ttc ctg gtg tat ttg cgc aat ccc 547 Arg His Arg Glu Ala His Leu Pro Phe Leu Val Tyr Leu Arg Asn Pro     135 140 145 acg atg ggt ggc gcc atg gcc tcg tgg ggt tca tct ggg cat ctc act 595 Thr Met Gly Gly Ala Met Ala Ser Trp Gly Ser Ser Gly His Leu Thr 150 155 160 165 ttt gcg gaa ccc ggc gcg cag ata ggt ttc ctg ggt cct cgc gtg gtg 643 Phe Ala Glu Pro Gly Ala Gln Ile Gly Phe Leu Gly Pro Arg Val Val                 170 175 180 gag tta acc act ggg cat gcg ctt cca gac ggt gtg cag cag gcg gag 691 Glu Leu Thr Thr Gly His Ala Leu Pro Asp Gly Val Gln Gln Ala Glu             185 190 195 aat ttg gtg aaa act ggt gtg att gat gga att gtg tcg cca ctc caa 739 Asn Leu Val Lys Thr Gly Val Ile Asp Gly Ile Val Ser Pro Leu Gln         200 205 210 ttg cgt gca gcg gtg gca aaa acc ctc aag gtt att cag ccg gta gag 787 Leu Arg Ala Ala Val Ala Lys Thr Leu Lys Val Ile Gln Pro Val Glu     215 220 225 gca acg gat cgt ttt tct cca aca act cct ggc gtg gca ctt ccg gtg 835 Ala Thr Asp Arg Phe Ser Pro Thr Thr Pro Gly Val Ala Leu Pro Val 230 235 240 245 atg gag gcg att gcg cgt tct cgt gac ccg cag agg cct gga atc ggg 883 Met Glu Ala Ile Ala Arg Ser Arg Asp Pro Gln Arg Pro Gly Ile Gly                 250 255 260 gag att atg gaa acg ttg ggg gca gac gtc gtc aag ctt tct ggt gcg 931 Glu Ile Met Glu Thr Leu Gly Ala Asp Val Val Lys Leu Ser Gly Ala             265 270 275 cgt gct ggc gca ttg agc ccg gct gtg cgc gtt gcc ctg gcg cgc atc 979 Arg Ala Gly Ala Leu Ser Pro Ala Val Arg Val Ala Leu Ala Arg Ile         280 285 290 ggg ggc cgg ccc gtg gtg ctg att ggg cag gat cgc cgc ttc acg ctt 1027 Gly Gly Arg Pro Val Val Leu Ile Gly Gln Asp Arg Arg Phe Thr Leu     295 300 305 ggg ccg cag gag ctg cgt ttt gcg cgt cgt ggc att tcg ctg gcg cgc 1075 Gly Pro Gln Glu Leu Arg Phe Ala Arg Arg Gly Ile Ser Leu Ala Arg 310 315 320 325 gag cta aac ctg ccg atc gtg tcc atc atc gac acc tcc ggc gcc gaa 1123 Glu Leu Asn Leu Pro Ile Val Ser Ile Ile Asp Thr Ser Gly Ala Glu                 330 335 340 ttg tcg cag gcg gct gag gag ctc ggc atc gca agc tcg att gcg cgc 1171 Leu Ser Gln Ala Ala Glu Glu Leu Gly Ile Ala Ser Ser Ile Ala Arg             345 350 355 acc ttg tcc aag ctt atc gac gct ccc ctc ccc acc gtt tcg gtc att 1219 Thr Leu Ser Lys Leu Ile Asp Ala Pro Leu Pro Thr Val Ser Val Ile         360 365 370 att ggt cag ggc gtt ggc ggt ggc gcg ctg gcc atg ctg ccc gcc gat 1267 Ile Gly Gln Gly Val Gly Gly Aly Lela Ala Met Leu Pro Ala Asp     375 380 385 ctg gtc tac gcg gcc gaa aac gcg tgg ctg tcc gca ttg cca cca gag 1315 Leu Val Tyr Ala Ala Glu Asn Ala Trp Leu Ser Ala Leu Pro Pro Glu 390 395 400 405 ggc gcc tcg gcc atc ctc ttc cgc gac acc aac cac gcc gcg gaa atc 1363 Gly Ala Ser Ala Ile Leu Phe Arg Asp Thr Asn His Ala Ala Glu Ile                 410 415 420 ata gag cga caa ggc gtg cag gcg cac gca ctt tta agc caa ggg ctt 1411 Ile Glu Arg Gln Gly Val Gln Ala His Ala Leu Leu Ser Gln Gly Leu             425 430 435 atc gac ggg atc gtc gcc gaa acc gag cac ttt gtt gaa gaa att ctc 1459 Ile Asp Gly Ile Val Ala Glu Thr Glu His Phe Val Glu Glu Ile Leu         440 445 450 ggc aca atc agc aac gcc ctc tcc gaa ttg gat aac aat ccg gag agg 1507 Gly Thr Ile Ser Asn Ala Leu Ser Glu Leu Asp Asn Asn Pro Glu Arg     455 460 465 gcg gga cgc gac agt cgc ttc aca cga ttt gag cgt tta gcg cag 1552 Ala Gly Arg Asp Ser Arg Phe Thr Arg Phe Glu Arg Leu Ala Gln 470 475 480 taaagaaaat tatgcgctga tca 1575 <210> 26 <211> 484 <212> PRT <213> Corynebacterium glutamicum <400> 26 Met Val Trp Gly Met Glu His Thr Ser Ala Leu Thr Leu Ile Asp Ser   1 5 10 15 Val Leu Asp Pro Asp Ser Phe Ile Ser Trp Asn Glu Thr Pro Gln Tyr              20 25 30 Asp Asn Leu Asn Gln Gly Tyr Ala Glu Thr Leu Glu Arg Ala Arg Ser          35 40 45 Lys Ala Lys Cys Asp Glu Ser Val Ile Thr Gly Glu Gly Thr Val Glu      50 55 60 Gly Ile Pro Val Ala Val Ile Leu Ser Asp Phe Ser Phe Leu Gly Gly  65 70 75 80 Ser Leu Gly Thr Val Ala Ser Val Arg Ile Met Lys Ala Ile His Arg                  85 90 95 Ala Thr Glu Leu Lys Leu Pro Leu Leu Val Ser Pro Ala Ser Gly Gly             100 105 110 Ala Arg Met Gln Glu Asp Asn Arg Ala Phe Val Met Met Val Ser Ile         115 120 125 Thr Ala Ala Val Gln Arg His Arg Glu Ala His Leu Pro Phe Leu Val     130 135 140 Tyr Leu Arg Asn Pro Thr Met Gly Gly Ala Met Ala Ser Trp Gly Ser 145 150 155 160 Ser Gly His Leu Thr Phe Ala Glu Pro Gly Ala Gln Ile Gly Phe Leu                 165 170 175 Gly Pro Arg Val Val Glu Leu Thr Thr Gly His Ala Leu Pro Asp Gly             180 185 190 Val Gln Gln Ala Glu Asn Leu Val Lys Thr Gly Val Ile Asp Gly Ile         195 200 205 Val Ser Pro Leu Gln Leu Arg Ala Ala Val Ala Lys Thr Leu Lys Val     210 215 220 Ile Gln Pro Val Glu Ala Thr Asp Arg Phe Ser Pro Thr Thr Pro Gly 225 230 235 240 Val Ala Leu Pro Val Met Glu Ala Ile Ala Arg Ser Arg Asp Pro Gln                 245 250 255 Arg Pro Gly Ile Gly Glu Ile Met Glu Thr Leu Gly Ala Asp Val Val             260 265 270 Lys Leu Ser Gly Ala Arg Ala Gly Ala Leu Ser Pro Ala Val Arg Val         275 280 285 Ala Leu Ala Arg Ile Gly Gly Arg Pro Val Val Leu Ile Gly Gln Asp     290 295 300 Arg Arg Phe Thr Leu Gly Pro Gln Glu Leu Arg Phe Ala Arg Arg Gly 305 310 315 320 Ile Ser Leu Ala Arg Glu Leu Asn Leu Pro Ile Val Ser Ile Ile Asp                 325 330 335 Thr Ser Gly Ala Glu Leu Ser Gln Ala Ala Glu Glu Leu Gly Ile Ala             340 345 350 Ser Ser Ile Ala Arg Thr Leu Ser Lys Leu Ile Asp Ala Pro Leu Pro         355 360 365 Thr Val Ser Val Ile Ile Gly Gln Gly Val Gly Gly Gly Ala Leu Ala     370 375 380 Met Leu Pro Ala Asp Leu Val Tyr Ala Ala Glu Asn Ala Trp Leu Ser 385 390 395 400 Ala Leu Pro Pro Glu Gly Ala Ser Ala Ile Leu Phe Arg Asp Thr Asn                 405 410 415 His Ala Ala Glu Ile Ile Glu Arg Gln Gly Val Gln Ala His Ala Leu             420 425 430 Leu Ser Gln Gly Leu Ile Asp Gly Ile Val Ala Glu Thr Glu His Phe         435 440 445 Val Glu Glu Ile Leu Gly Thr Ile Ser Asn Ala Leu Ser Glu Leu Asp     450 455 460 Asn Asn Pro Glu Arg Ala Gly Arg Asp Ser Arg Phe Thr Arg Phe Glu 465 470 475 480 Arg Leu Ala Gln <210> 27 <211> 1056 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1033) <223> RXA01764 <400> 27 ttttcaaaat taatagttga cattttcaac gttatgagtt ttcattggta tcacgccccg 60 acgaagtgtc tgggatcaca aaccttcaaa ggagtttgaa atg tct ctc aat gga 115                                             Met Ser Leu Asn Gly                                               1 5 aaa gtc gcc atc gtt acc gga tct ggt gca gga ctt ggt cgt tcc ttc 163 Lys Val Ala Ile Val Thr Gly Ser Gly Ala Gly Leu Gly Arg Ser Phe                  10 15 20 gct cag gag ctt gcc cgt cag ggt gca tct gtc atc gtc aat gac gta 211 Ala Gln Glu Leu Ala Arg Gln Gly Ala Ser Val Ile Val Asn Asp Val              25 30 35 aac cag gca gcc gca gat gag act gtc gca gca atc acc gaa gcc ggc 259 Asn Gln Ala Ala Ala Asp Glu Thr Val Ala Ala Ile Thr Glu Ala Gly          40 45 50 ggc aaa gcc gcc gcc gtt atc gcc ccc gtt gga ccc tct gaa agc gcc 307 Gly Lys Ala Ala Ala Val Ile Ala Pro Val Gly Pro Ser Glu Ser Ala      55 60 65 gca ttg ctg gtg cgg gag gcc gtc gac aag ttc ggt tct ttg gac att 355 Ala Leu Leu Val Arg Glu Ala Val Asp Lys Phe Gly Ser Leu Asp Ile  70 75 80 85 ctt gtc aca aac gcg ggc atc ctt cgt gat agg tcc ctg ctg aag atg 403 Leu Val Thr Asn Ala Gly Ile Leu Arg Asp Arg Ser Leu Leu Lys Met                  90 95 100 acg gac gat gat ttc gat gca gtc att aac gtg cac ctc aag ggc act 451 Thr Asp Asp Asp Phe Asp Ala Val Ile Asn Val His Leu Lys Gly Thr             105 110 115 ttc acc tgt gtt cgc gag gca ttt gga tac ttc aag gag aat gga atc 499 Phe Thr Cys Val Arg Glu Ala Phe Gly Tyr Phe Lys Glu Asn Gly Ile         120 125 130 gcg ggg cgc atc gtc acg att ggt tct ccc acc ggg cag cgc ggc aac 547 Ala Gly Arg Ile Val Thr Ile Gly Ser Pro Thr Gly Gln Arg Gly Asn     135 140 145 ttc gga cag agc aat tac gct gca gct aag gcg ggc att gtg ggt atg 595 Phe Gly Gln Ser Asn Tyr Ala Ala Ala Lys Ala Gly Ile Val Gly Met 150 155 160 165 gtt cgc acg tgg gcg ctg gag atg aag cgc gca ggt gtc acc att aac 643 Val Arg Thr Trp Ala Leu Glu Met Lys Arg Ala Gly Val Thr Ile Asn                 170 175 180 gcg atc att ccg gaa gca gcc acc gat atg acc aag acg gtg cca tat 691 Ala Ile Ile Pro Glu Ala Ala Thr Asp Met Thr Lys Thr Val Pro Tyr             185 190 195 ttc cag aag gct gta gag gcc gat gag cgt ggc gag gcc atg cca gca 739 Phe Gln Lys Ala Val Glu Ala Asp Glu Arg Gly Glu Ala Met Pro Ala         200 205 210 ttc ttc cgc gag acc cta ggt ttt ggc act cct cag gat gtt gcg gga 787 Phe Phe Arg Glu Thr Leu Gly Phe Gly Thr Pro Gln Asp Val Ala Gly     215 220 225 ctt gtg gcc ttc ctt tcc tct gat gag gca gcg aat att tct gga cag 835 Leu Val Ala Phe Leu Ser Ser Asp Glu Ala Ala Asn Ile Ser Gly Gln 230 235 240 245 gcc atc ggt gca ggc ggc gac cgc atg cag gtg tgg aag cac cca gag 883 Ala Ile Gly Ala Gly Gly Asp Arg Met Gln Val Trp Lys His Pro Glu                 250 255 260 cca gca gtt act gaa ttt aac cca ggt ggc tgg acc tat gaa gca ctg 931 Pro Ala Val Thr Glu Phe Asn Pro Gly Gly Trp Thr Tyr Glu Ala Leu             265 270 275 cag gaa cgt ggc aag aac att att gag ggc aac ctg cag tcc gtc ggt 979 Gln Glu Arg Gly Lys Asn Ile Ile Glu Gly Asn Leu Gln Ser Val Gly         280 285 290 gtc gtt ttc cct gaa ctg ccg gca gag ctt cag cca caa atc cca gtc 1027 Val Val Phe Pro Glu Leu Pro Ala Glu Leu Gln Pro Gln Ile Pro Val     295 300 305 aag gca taacaccgca caccaagaat ttt 1056 Lys ala 310 <210> 28 <211> 311 <212> PRT <213> Corynebacterium glutamicum <400> 28 Met Ser Leu Asn Gly Lys Val Ala Ile Val Thr Gly Ser Gly Ala Gly   1 5 10 15 Leu Gly Arg Ser Phe Ala Gln Glu Leu Ala Arg Gln Gly Ala Ser Val              20 25 30 Ile Val Asn Asp Val Asn Gln Ala Ala Ala Asp Glu Thr Val Ala Ala          35 40 45 Ile Thr Glu Ala Gly Gly Lys Ala Ala Ala Val Ile Ala Pro Val Gly      50 55 60 Pro Ser Glu Ser Ala Ala Leu Leu Val Arg Glu Ala Val Asp Lys Phe  65 70 75 80 Gly Ser Leu Asp Ile Leu Val Thr Asn Ala Gly Ile Leu Arg Asp Arg                  85 90 95 Ser Leu Leu Lys Met Thr Asp Asp Asp Phe Asp Ala Val Ile Asn Val             100 105 110 His Leu Lys Gly Thr Phe Thr Cys Val Arg Glu Ala Phe Gly Tyr Phe         115 120 125 Lys Glu Asn Gly Ile Ala Gly Arg Ile Val Thr Ile Gly Ser Pro Thr     130 135 140 Gly Gln Arg Gly Asn Phe Gly Gln Ser Asn Tyr Ala Ala Ala Lys Ala 145 150 155 160 Gly Ile Val Gly Met Val Arg Thr Trp Ala Leu Glu Met Lys Arg Ala                 165 170 175 Gly Val Thr Ile Asn Ala Ile Ile Pro Glu Ala Ala Thr Asp Met Thr             180 185 190 Lys Thr Val Pro Tyr Phe Gln Lys Ala Val Glu Ala Asp Glu Arg Gly         195 200 205 Glu Ala Met Pro Ala Phe Phe Arg Glu Thr Leu Gly Phe Gly Thr Pro     210 215 220 Gln Asp Val Ala Gly Leu Val Ala Phe Leu Ser Ser Asp Glu Ala Ala 225 230 235 240 Asn Ile Ser Gly Gln Ala Ile Gly Ala Gly Gly Asp Arg Met Gln Val                 245 250 255 Trp Lys His Pro Glu Pro Ala Val Thr Glu Phe Asn Pro Gly Gly Trp             260 265 270 Thr Tyr Glu Ala Leu Gln Glu Arg Gly Lys Asn Ile Ile Glu Gly Asn         275 280 285 Leu Gln Ser Val Gly Val Val Phe Pro Glu Leu Pro Ala Glu Leu Gln     290 295 300 Pro Gln Ile Pro Val Lys Ala 305 310 <210> 29 <211> 1827 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1804) <223> RXN02487 <400> 29 tcatagctac gcgcatgccc acattctaga tcgccgaaga aagcagcggg acgtctctat 60 atactaaagg gcactaaagc aacgcagttg aagggacacc atg tca gca tac gaa 115                                             Met Ser Ala Tyr Glu                                               1 5 acc aaa gaa tgg ctc cag cac tac cca gag tgg acg cca cac tcg ctg 163 Thr Lys Glu Trp Leu Gln His Tyr Pro Glu Trp Thr Pro His Ser Leu                  10 15 20 gaa tat ggc gac acc acc ctg ctg gac gtt tac gac aac aac ctg gcc 211 Glu Tyr Gly Asp Thr Thr Leu Leu Asp Val Tyr Asp Asn Asn Leu Ala              25 30 35 att aac gca gac aag cca gcc acc tac ttt ttc ggt cgt tca caa acc 259 Ile Asn Ala Asp Lys Pro Ala Thr Tyr Phe Phe Gly Arg Ser Gln Thr          40 45 50 tac ggt gaa ctg gac aaa gaa gtc cgc aaa act gcc gct ggc ctg cgc 307 Tyr Gly Glu Leu Asp Lys Glu Val Arg Lys Thr Ala Ala Gly Leu Arg      55 60 65 gca cta ggt gtc cgc ccc ggc gat cac gta gcg att atc ctc ccc aac 355 Ala Leu Gly Val Arg Pro Gly Asp His Val Ala Ile Ile Leu Pro Asn  70 75 80 85 tgc cca cag cac atc gca gct ttc tac gca gtg ctg aaa ctc ggc gca 403 Cys Pro Gln His Ile Ala Ala Phe Tyr Ala Val Leu Lys Leu Gly Ala                  90 95 100 gta gtc att gag cac aac ccg ctc tac acc gcc cac gaa ctg ctc gaa 451 Val Val Ile Glu His Asn Pro Leu Tyr Thr Ala His Glu Leu Leu Glu             105 110 115 ccc ttc aaa gac cac ggt gcc cgc gtt gcc atc gtc tgg gac aaa gcc 499 Pro Phe Lys Asp His Gly Ala Arg Val Ala Ile Val Trp Asp Lys Ala         120 125 130 tcc ccc acc gtc gaa cag cta cgt gga cag acc cag ttg gaa acc atc 547 Ser Pro Thr Val Glu Gln Leu Arg Gly Gln Thr Gln Leu Glu Thr Ile     135 140 145 gtg tcg gtc aac atg atc aac gcg atg cca cca ctc cag cgc cta gca 595 Val Ser Val Asn Met Ile Asn Ala Met Pro Pro Leu Gln Arg Leu Ala 150 155 160 165 ctt cgg ctc cca atc cct gca ctg cgc aag agc cgc gaa tcc ctc tcc 643 Leu Arg Leu Pro Ile Pro Ala Leu Arg Lys Ser Arg Glu Ser Leu Ser                 170 175 180 ggc gca gcc ccc aac acc gtt cct ttt gaa acc ctg acc agc gca gca 691 Gly Ala Ala Pro Asn Thr Val Pro Phe Glu Thr Leu Thr Ser Ala Ala             185 190 195 atg ggc ggc gac ggc gac gac gta gtt tca gaa ccc acc gtg acc aaa 739 Met Gly Gly Asp Gly Asp Asp Val Val Ser Glu Pro Thr Val Thr Lys         200 205 210 gaa tcc gtc gcg ctg atc ctc tac acc tcc ggc acc acc gga cgc ccc 787 Glu Ser Val Ala Leu Ile Leu Tyr Thr Ser Gly Thr Thr Gly Arg Pro     215 220 225 aag ggt gcc cag ctc acc cac gga aac ctg ttc ttc aat ctt ctt caa 835 Lys Gly Ala Gln Leu Thr His Gly Asn Leu Phe Phe Asn Leu Leu Gln 230 235 240 245 gga aag cac tgg gtt cca ggt ctc gga gac aaa cca gaa cgc atg ctt 883 Gly Lys His Trp Val Pro Gly Leu Gly Asp Lys Pro Glu Arg Met Leu                 250 255 260 gca gcc cta cca atg ttc cac gca tac ggt ctg acc atg gtc ggc aca 931 Ala Ala Leu Pro Met Phe His Ala Tyr Gly Leu Thr Met Val Gly Thr             265 270 275 ctg tcc gtg ttc atc ggt ggc gaa atg gtg cta ctt ccc acc cca cgc 979 Leu Ser Val Phe Ile Gly Gly Glu Met Val Leu Leu Pro Thr Pro Arg         280 285 290 atc gac ctg atc atg aac gta atg aaa aag cac acc cca acc tgg cta 1027 Ile Asp Leu Ile Met Asn Val Met Lys Lys His Thr Pro Thr Trp Leu     295 300 305 cca ggc gtg ccc acc ctt tac gaa aaa atc gtc gac gcc tcc gaa aaa 1075 Pro Gly Val Pro Thr Leu Tyr Glu Lys Ile Val Asp Ala Ser Glu Lys 310 315 320 325 gaa gga atc ccc atc aag gga gtc cgc aac gcc ttc tcc ggt gca tcc 1123 Glu Gly Ile Pro Ile Lys Gly Val Arg Asn Ala Phe Ser Gly Ala Ser                 330 335 340 aca ctc tcc cag cgc acc gtt gaa cgc tgg gaa aag cac acc ggc gga 1171 Thr Leu Ser Gln Arg Thr Val Glu Arg Trp Glu Lys His Thr Gly Gly             345 350 355 cgc ctc gtc gaa ggc tac ggc ctc acc gaa acc tcc ccc atc atc gtg 1219 Arg Leu Val Glu Gly Tyr Gly Leu Thr Glu Thr Ser Pro Ile Ile Val         360 365 370 ggt aac ccc atg agc gat cac cga cgc caa ggc tac gta gga atc ccc 1267 Gly Asn Pro Met Ser Asp His Arg Arg Gln Gly Tyr Val Gly Ile Pro     375 380 385 ttc ccc gac acc atc gtg cgc atc gca aac cca gaa aac ctc gac gaa 1315 Phe Pro Asp Thr Ile Val Arg Ile Ala Asn Pro Glu Asn Leu Asp Glu 390 395 400 405 acc atg ccc gac ggc agc gaa ggc gaa gtc cta gtc aag ggc cca cag 1363 Thr Met Pro Asp Gly Ser Glu Gly Glu Val Leu Val Lys Gly Pro Gln                 410 415 420 gtg ttc aag ggt tac ctc aac cag gaa gaa gcc acc aag aac agc ttc 1411 Val Phe Lys Gly Tyr Leu Asn Gln Glu Glu Ala Thr Lys Asn Ser Phe             425 430 435 cac ggc gag tgg tac cgc acc ggc gac gtc gga gtg atg gaa gaa gac 1459 His Gly Glu Trp Tyr Arg Thr Gly Asp Val Gly Val Met Glu Glu Asp         440 445 450 ggg ttc atc cgc cta gtt gct cgc atc aag gaa gtc atc atc act ggc 1507 Gly Phe Ile Arg Leu Val Ala Arg Ile Lys Glu Val Ile Ile Thr Gly     455 460 465 ggt ttc aac gtg tac cca gct gag gtt gaa gaa gtc ctc gca gag cac 1555 Gly Phe Asn Val Tyr Pro Ala Glu Val Glu Glu Val Leu Ala Glu His 470 475 480 485 cca gac att gaa gat tcc gca gtc gtt ggt atc ccg cgt gaa gac ggc 1603 Pro Asp Ile Glu Asp Ser Ala Val Val Gly Ile Pro Arg Glu Asp Gly                 490 495 500 tcc gaa aac gtc gtt gct gcc atc act ttg gtg gaa ggt gca gcg ctg 1651 Ser Glu Asn Val Val Ala Ala Ile Thr Leu Val Glu Gly Ala Ala Leu             505 510 515 gat ccg gat ggc ctg aag gaa ttc gcc cgc aag aac ctc acc cgc tac 1699 Asp Pro Asp Gly Leu Lys Glu Phe Ala Arg Lys Asn Leu Thr Arg Tyr         520 525 530 aag gtt ccg cgc act ttc tac cac ttt gag gag atg ccg cgg gat cag 1747 Lys Val Pro Arg Thr Phe Tyr His Phe Glu Glu Met Pro Arg Asp Gln     535 540 545 atg ggc aag att agg cgt cgt gaa gtg cag gcg gag ttg ttg aag aag 1795 Met Gly Lys Ile Arg Arg Arg Glu Val Gln Ala Glu Leu Leu Lys Lys 550 555 560 565 ctc ggc aag tagacgccga tttaagaggt cga 1827 Leu Gly Lys <210> 30 <211> 568 <212> PRT <213> Corynebacterium glutamicum <400> 30 Met Ser Ala Tyr Glu Thr Lys Glu Trp Leu Gln His Tyr Pro Glu Trp   1 5 10 15 Thr Pro His Ser Leu Glu Tyr Gly Asp Thr Thr Leu Leu Asp Val Tyr              20 25 30 Asp Asn Asn Leu Ala Ile Asn Ala Asp Lys Pro Ala Thr Tyr Phe Phe          35 40 45 Gly Arg Ser Gln Thr Tyr Gly Glu Leu Asp Lys Glu Val Arg Lys Thr      50 55 60 Ala Ala Gly Leu Arg Ala Leu Gly Val Arg Pro Gly Asp His Val Ala  65 70 75 80 Ile Ile Leu Pro Asn Cys Pro Gln His Ile Ala Ala Phe Tyr Ala Val                  85 90 95 Leu Lys Leu Gly Ala Val Val Ile Glu His Asn Pro Leu Tyr Thr Ala             100 105 110 His Glu Leu Leu Glu Pro Phe Lys Asp His Gly Ala Arg Val Ala Ile         115 120 125 Val Trp Asp Lys Ala Ser Pro Thr Val Glu Gln Leu Arg Gly Gln Thr     130 135 140 Gln Leu Glu Thr Ile Val Ser Val Asn Met Ile Asn Ala Met Pro Pro 145 150 155 160 Leu Gln Arg Leu Ala Leu Arg Leu Pro Ile Pro Ala Leu Arg Lys Ser                 165 170 175 Arg Glu Ser Leu Ser Gly Ala Ala Pro Asn Thr Val Pro Phe Glu Thr             180 185 190 Leu Thr Ser Ala Ala Met Gly Gly Asp Gly Asp Asp Val Val Ser Glu         195 200 205 Pro Thr Val Thr Lys Glu Ser Val Ala Leu Ile Leu Tyr Thr Ser Gly     210 215 220 Thr Thr Gly Arg Pro Lys Gly Ala Gln Leu Thr His Gly Asn Leu Phe 225 230 235 240 Phe Asn Leu Leu Gln Gly Lys His Trp Val Pro Gly Leu Gly Asp Lys                 245 250 255 Pro Glu Arg Met Leu Ala Ala Leu Pro Met Phe His Ala Tyr Gly Leu             260 265 270 Thr Met Val Gly Thr Leu Ser Val Phe Ile Gly Gly Glu Met Val Leu         275 280 285 Leu Pro Thr Pro Arg Ile Asp Leu Ile Met Asn Val Met Lys Lys His     290 295 300 Thr Pro Thr Trp Leu Pro Gly Val Pro Thr Leu Tyr Glu Lys Ile Val 305 310 315 320 Asp Ala Ser Glu Lys Glu Gly Ile Pro Ile Lys Gly Val Arg Asn Ala                 325 330 335 Phe Ser Gly Ala Ser Thr Leu Ser Gln Arg Thr Val Glu Arg Trp Glu             340 345 350 Lys His Thr Gly Gly Arg Leu Val Glu Gly Tyr Gly Leu Thr Glu Thr         355 360 365 Ser Pro Ile Ile Val Gly Asn Pro Met Ser Asp His Arg Arg Gln Gly     370 375 380 Tyr Val Gly Ile Pro Phe Pro Asp Thr Ile Val Arg Ile Ala Asn Pro 385 390 395 400 Glu Asn Leu Asp Glu Thr Met Pro Asp Gly Ser Glu Gly Glu Val Leu                 405 410 415 Val Lys Gly Pro Gln Val Phe Lys Gly Tyr Leu Asn Gln Glu Glu Ala             420 425 430 Thr Lys Asn Ser Phe His Gly Glu Trp Tyr Arg Thr Gly Asp Val Gly         435 440 445 Val Met Glu Glu Asp Gly Phe Ile Arg Leu Val Ala Arg Ile Lys Glu     450 455 460 Val Ile Ile Thr Gly Gly Phe Asn Val Tyr Pro Ala Glu Val Glu Glu 465 470 475 480 Val Leu Ala Glu His Pro Asp Ile Glu Asp Ser Ala Val Val Gly Ile                 485 490 495 Pro Arg Glu Asp Gly Ser Glu Asn Val Val Ala Ala Ile Thr Leu Val             500 505 510 Glu Gly Ala Ala Leu Asp Pro Asp Gly Leu Lys Glu Phe Ala Arg Lys         515 520 525 Asn Leu Thr Arg Tyr Lys Val Pro Arg Thr Phe Tyr His Phe Glu Glu     530 535 540 Met Pro Arg Asp Gln Met Gly Lys Ile Arg Arg Arg Glu Val Gln Ala 545 550 555 560 Glu Leu Leu Lys Lys Leu Gly Lys                 565 <210> 31 <211> 411 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (388) <223> FRXA02487 <400> 31 ggcgagtggt accgcaccgc gacgtcggag tgatgaagaa gccgggttca tccgcctagt 60 tgctcgcatc aagaaagtca tcatcactgg cggtttcaac gtg tac cca gct gag 115                                             Val Tyr Pro Ala Glu                                               1 5 gtt gaa gaa gtc ctc gca gag cac cca gac att gaa gat tcc gca gtc 163 Val Glu Glu Val Leu Ala Glu His Pro Asp Ile Glu Asp Ser Ala Val                  10 15 20 gtt ggt atc ccg cgt gaa gac ggc tcc gaa aac gtc gtt gct gcc atc 211 Val Gly Ile Pro Arg Glu Asp Gly Ser Glu Asn Val Val Ala Ala Ile              25 30 35 act ttg gtg gaa ggt gca gcg ctg gat ccg gat ggc ctg aag gaa ttc 259 Thr Leu Val Glu Gly Ala Ala Leu Asp Pro Asp Gly Leu Lys Glu Phe          40 45 50 gcc cgc aag aac ctc acc cgc tac aag gtt ccg cgc act ttc tac cac 307 Ala Arg Lys Asn Leu Thr Arg Tyr Lys Val Pro Arg Thr Phe Tyr His      55 60 65 ttt gag gag atg ccg cgg gat cag atg ggc aag att agg cgt cgt gaa 355 Phe Glu Glu Met Pro Arg Asp Gln Met Gly Lys Ile Arg Arg Arg Glu  70 75 80 85 gtg cag gcg gag ttg ttg aag aag ctc ggc aag tagacgccga tttaagaggt 408 Val Gln Ala Glu Leu Leu Lys Lys Leu Gly Lys                  90 95 cga 411 <210> 32 <211> 96 <212> PRT <213> Corynebacterium glutamicum <400> 32 Val Tyr Pro Ala Glu Val Glu Glu Val Leu Ala Glu His Pro Asp Ile   1 5 10 15 Glu Asp Ser Ala Val Val Gly Ile Pro Arg Glu Asp Gly Ser Glu Asn              20 25 30 Val Val Ala Ala Ile Thr Leu Val Glu Gly Ala Ala Leu Asp Pro Asp          35 40 45 Gly Leu Lys Glu Phe Ala Arg Lys Asn Leu Thr Arg Tyr Lys Val Pro      50 55 60 Arg Thr Phe Tyr His Phe Glu Glu Met Pro Arg Asp Gln Met Gly Lys  65 70 75 80 Ile Arg Arg Arg Glu Val Gln Ala Glu Leu Leu Lys Lys Leu Gly Lys                  85 90 95 <210> 33 <211> 913 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (913) <223> FRXA02490 <400> 33 tcatagctac gcgcatgccc acattctaga tcgccgaaga aagcagcggg acgtctctat 60 atactaaagg gcactaaagc aacgcagttg aagggacacc atg tca gca tac gaa 115                                             Met Ser Ala Tyr Glu                                               1 5 acc aaa gaa tgg ctc cag cac tac cca gag tgg acg cca cac tcg ctg 163 Thr Lys Glu Trp Leu Gln His Tyr Pro Glu Trp Thr Pro His Ser Leu                  10 15 20 gaa tat ggc gac acc acc ctg ctg gac gtt tac gac aac aac ctg gcc 211 Glu Tyr Gly Asp Thr Thr Leu Leu Asp Val Tyr Asp Asn Asn Leu Ala              25 30 35 att aac gca gac aag cca gcc acc tac ttt ttc ggt cgt tca caa acc 259 Ile Asn Ala Asp Lys Pro Ala Thr Tyr Phe Phe Gly Arg Ser Gln Thr          40 45 50 tac ggt gaa ctg gac aaa gaa gtc cgc aaa act gcc gct ggc ctg cgc 307 Tyr Gly Glu Leu Asp Lys Glu Val Arg Lys Thr Ala Ala Gly Leu Arg      55 60 65 gca cta ggt gtc cgc ccc ggc gat cac gta gcg att atc ctc ccc aac 355 Ala Leu Gly Val Arg Pro Gly Asp His Val Ala Ile Ile Leu Pro Asn  70 75 80 85 tgc cca cag cac atc gca gct ttc tac gca gtg ctg aaa ctc ggc gca 403 Cys Pro Gln His Ile Ala Ala Phe Tyr Ala Val Leu Lys Leu Gly Ala                  90 95 100 gta gtc att gag cac aac ccg ctc tac acc gcc cac gaa ctg ctc gaa 451 Val Val Ile Glu His Asn Pro Leu Tyr Thr Ala His Glu Leu Leu Glu             105 110 115 ccc ttc aaa gac cac ggt gcc cgc gtt gcc atc gtc tgg gac aaa gcc 499 Pro Phe Lys Asp His Gly Ala Arg Val Ala Ile Val Trp Asp Lys Ala         120 125 130 tcc ccc acc gtc gaa cag cta cgt gga cag acc cag ttg gaa acc atc 547 Ser Pro Thr Val Glu Gln Leu Arg Gly Gln Thr Gln Leu Glu Thr Ile     135 140 145 gtg tcg gtc aac atg atc aac gcg atg cca cca ctc cag cgc cta gca 595 Val Ser Val Asn Met Ile Asn Ala Met Pro Pro Leu Gln Arg Leu Ala 150 155 160 165 ctt cgg ctc cca atc cct gca ctg cgc aag agc cgc gaa tcc ctc tcc 643 Leu Arg Leu Pro Ile Pro Ala Leu Arg Lys Ser Arg Glu Ser Leu Ser                 170 175 180 ggc gca gcc ccc aac acc gtt cct ttt gaa acc ctg acc agc gca gca 691 Gly Ala Ala Pro Asn Thr Val Pro Phe Glu Thr Leu Thr Ser Ala Ala             185 190 195 atg ggc ggc gac ggc gac gac gta gtt tca gaa ccc acc gtg acc aaa 739 Met Gly Gly Asp Gly Asp Asp Val Val Ser Glu Pro Thr Val Thr Lys         200 205 210 gaa tcc gtc gcg ctg atc ctc tac acc tcc ggc acc acc gga cgc ccc 787 Glu Ser Val Ala Leu Ile Leu Tyr Thr Ser Gly Thr Thr Gly Arg Pro     215 220 225 aag ggt gcc cag ctc acc cac gga aac ctg ttc tcc aat ctc ctc caa 835 Lys Gly Ala Gln Leu Thr His Gly Asn Leu Phe Ser Asn Leu Leu Gln 230 235 240 245 gga aag cac tgg gtt cca ggt ctc gga gac aaa cca gaa cgc atg ctt 883 Gly Lys His Trp Val Pro Gly Leu Gly Asp Lys Pro Glu Arg Met Leu                 250 255 260 gca gcc cta cca atg ttc cac gca tac ggt 913 Ala Ala Leu Pro Met Phe His Ala Tyr Gly             265 270 <210> 34 <211> 271 <212> PRT <213> Corynebacterium glutamicum <400> 34 Met Ser Ala Tyr Glu Thr Lys Glu Trp Leu Gln His Tyr Pro Glu Trp   1 5 10 15 Thr Pro His Ser Leu Glu Tyr Gly Asp Thr Thr Leu Leu Asp Val Tyr              20 25 30 Asp Asn Asn Leu Ala Ile Asn Ala Asp Lys Pro Ala Thr Tyr Phe Phe          35 40 45 Gly Arg Ser Gln Thr Tyr Gly Glu Leu Asp Lys Glu Val Arg Lys Thr      50 55 60 Ala Ala Gly Leu Arg Ala Leu Gly Val Arg Pro Gly Asp His Val Ala  65 70 75 80 Ile Ile Leu Pro Asn Cys Pro Gln His Ile Ala Ala Phe Tyr Ala Val                  85 90 95 Leu Lys Leu Gly Ala Val Val Ile Glu His Asn Pro Leu Tyr Thr Ala             100 105 110 His Glu Leu Leu Glu Pro Phe Lys Asp His Gly Ala Arg Val Ala Ile         115 120 125 Val Trp Asp Lys Ala Ser Pro Thr Val Glu Gln Leu Arg Gly Gln Thr     130 135 140 Gln Leu Glu Thr Ile Val Ser Val Asn Met Ile Asn Ala Met Pro Pro 145 150 155 160 Leu Gln Arg Leu Ala Leu Arg Leu Pro Ile Pro Ala Leu Arg Lys Ser                 165 170 175 Arg Glu Ser Leu Ser Gly Ala Ala Pro Asn Thr Val Pro Phe Glu Thr             180 185 190 Leu Thr Ser Ala Ala Met Gly Gly Asp Gly Asp Asp Val Val Ser Glu         195 200 205 Pro Thr Val Thr Lys Glu Ser Val Ala Leu Ile Leu Tyr Thr Ser Gly     210 215 220 Thr Thr Gly Arg Pro Lys Gly Ala Gln Leu Thr His Gly Asn Leu Phe 225 230 235 240 Ser Asn Leu Leu Gln Gly Lys His Trp Val Pro Gly Leu Gly Asp Lys                 245 250 255 Pro Glu Arg Met Leu Ala Ala Leu Pro Met Phe His Ala Tyr Gly             260 265 270 <210> 35 <211> 414 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (391) <223> RXA01467 <400> 35 gcgtcatctt tagccttgct ttatgagctt ttccccgcaa tgagccgcgt tgtgtatcca 60 taagtcttag cctacaagcg ctttgaggta gtttgggatc atg gat ttc aac gac 115                                             Met Asp Phe Asn Asp                                               1 5 aaa gcc gct tca gaa aac gct gta aag act ggc gca gaa ggc ccc aac 163 Lys Ala Ala Ser Glu Asn Ala Val Lys Thr Gly Ala Glu Gly Pro Asn                  10 15 20 gtt ttc gcg agc gtg gcc aag att ttg cag gat gtt ggc gga att tca 211 Val Phe Ala Ser Val Ala Lys Ile Leu Gln Asp Val Gly Gly Ile Ser              25 30 35 gcc gaa gac gtc act ccg gaa tct cgt ttt act gag gat ttg gca gtg 259 Ala Glu Asp Val Thr Pro Glu Ser Arg Phe Thr Glu Asp Leu Ala Val          40 45 50 agc tca ctc aat tac atc gag ttg att gtc aat gcg gag gac gca ttt 307 Ser Ser Leu Asn Tyr Ile Glu Leu Ile Val Asn Ala Glu Asp Ala Phe      55 60 65 ggt gtt cgc att gag gac gcc gat gcc aag gat ttg acc acc gtg cag 355 Gly Val Arg Ile Glu Asp Ala Asp Ala Lys Asp Leu Thr Thr Val Gln  70 75 80 85 gat ttg att gac ttt att aac acc aat aag gct gat tagcgggaaa 401 Asp Leu Ile Asp Phe Ile Asn Thr Asn Lys Ala Asp                  90 95 atttcgccca aaa 414 <210> 36 <211> 97 <212> PRT <213> Corynebacterium glutamicum <400> 36 Met Asp Phe Asn Asp Lys Ala Ala Ser Glu Asn Ala Val Lys Thr Gly   1 5 10 15 Ala Glu Gly Pro Asn Val Phe Ala Ser Val Ala Lys Ile Leu Gln Asp              20 25 30 Val Gly Gly Ile Ser Ala Glu Asp Val Thr Pro Glu Ser Arg Phe Thr          35 40 45 Glu Asp Leu Ala Val Ser Ser Leu Asn Tyr Ile Glu Leu Ile Val Asn      50 55 60 Ala Glu Asp Ala Phe Gly Val Arg Ile Glu Asp Ala Asp Ala Lys Asp  65 70 75 80 Leu Thr Thr Val Gln Asp Leu Ile Asp Phe Ile Asn Thr Asn Lys Ala                  85 90 95 Asp <210> 37 <211> 298 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (298) <223> RXA00796 <400> 37 ctggaatccc aaagcgcttg catgacgcgg aaagttaaca taggctaggt acgtcaagtt 60 gttgatacat caacttaatt aacttttaga ggagtacacc atg agc aag atc gcc 115                                             Met Ser Lys Ile Ala                                               1 5 atc atc acc ggt tcc acc cgt cca ggc cgc gtc aac att gac gta gcc 163 Ile Ile Thr Gly Ser Thr Arg Pro Gly Arg Val Asn Ile Asp Val Ala                  10 15 20 aac tgg gtt ctc gag cgc gca caa gag cgc aac gat gca cag tac gag 211 Asn Trp Val Leu Glu Arg Ala Gln Glu Arg Asn Asp Ala Gln Tyr Glu              25 30 35 ctc gtt gat atc gcc gat ttc aac ttc ccc gtc ctc gac gaa gca atg 259 Leu Val Asp Ile Ala Asp Phe Asn Phe Pro Val Leu Asp Glu Ala Met          40 45 50 cca gcc ggc tac ggc cag tat gca aac gag cac acc aag 298 Pro Ala Gly Tyr Gly Gln Tyr Ala Asn Glu His Thr Lys      55 60 65 <210> 38 <211> 66 <212> PRT <213> Corynebacterium glutamicum <400> 38 Met Ser Lys Ile Ala Ile Ile Thr Gly Ser Thr Arg Pro Gly Arg Val   1 5 10 15 Asn Ile Asp Val Ala Asn Trp Val Leu Glu Arg Ala Gln Glu Arg Asn              20 25 30 Asp Ala Gln Tyr Glu Leu Val Asp Ile Ala Asp Phe Asn Phe Pro Val          35 40 45 Leu Asp Glu Ala Met Pro Ala Gly Tyr Gly Gln Tyr Ala Asn Glu His      50 55 60 Thr lys  65 <210> 39 <211> 666 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (643) <223> RXA01897 <400> 39 ctatttagat cgttccggaa ccgatccacg cgccgatatc cactccctgg atgaactctt 60 tcactaggct ggcctttatt gtttccggaa aggggttgct atg aaa att ggt gtc 115                                             Met Lys Ile Gly Val                                               1 5 atc ctg ggc agt atc cgc gaa ggc cgc ttc ggc caa ggc gtt gcc gat 163 Ile Leu Gly Ser Ile Arg Glu Gly Arg Phe Gly Gln Gly Val Ala Asp                  10 15 20 tgg gtc atg gaa caa atc ggg gct tat gac gca ccc gat gtg gaa ttt 211 Trp Val Met Glu Gln Ile Gly Ala Tyr Asp Ala Pro Asp Val Glu Phe              25 30 35 gaa ctc atc gac ctc aaa gct ttc aac gtg ccc ctg ttg gaa tcc gcg 259 Glu Leu Ile Asp Leu Lys Ala Phe Asn Val Pro Leu Leu Glu Ser Ala          40 45 50 aca gtt cca ggt tcc gcg gat aaa cag tac gac gac ccg cgc gta act 307 Thr Val Pro Gly Ser Ala Asp Lys Gln Tyr Asp Asp Pro Arg Val Thr      55 60 65 gcc tgg tca cag gcc att gat gcc tgc gat gcc ttc ctt ttc atc acc 355 Ala Trp Ser Gln Ala Ile Asp Ala Cys Asp Ala Phe Leu Phe Ile Thr  70 75 80 85 ccg gaa tac aac cac ggt gtg ccc ggc gcg ttc aaa aat gcg tat gac 403 Pro Glu Tyr Asn His Gly Val Pro Gly Ala Phe Lys Asn Ala Tyr Asp                  90 95 100 atc ctg ggc aat gaa tgg ctg aac aaa acc gtc ggt ttc att tcc tac 451 Ile Leu Gly Asn Glu Trp Leu Asn Lys Thr Val Gly Phe Ile Ser Tyr             105 110 115 ggt gca gtc gaa ggg atc cgt gtt gtc gaa cag tgg cgt cag atc gtc 499 Gly Ala Val Glu Gly Ile Arg Val Val Glu Gln Trp Arg Gln Ile Val         120 125 130 gcc acc ttc aac atg tac gat atc cgc agc cag cta tcc ttt tcc acc 547 Ala Thr Phe Asn Met Tyr Asp Ile Arg Ser Gln Leu Ser Phe Ser Thr     135 140 145 ttc acc gag aac aac aac ggc act ttt gcg ccc aat gat cga cgc ccc 595 Phe Thr Glu Asn Asn Asn Gly Thr Phe Ala Pro Asn Asp Arg Arg Pro 150 155 160 165 ggt gaa cta atc cgc ctc ctt gat agc ctc cta acg gct gtc cgc gat 643 Gly Glu Leu Ile Arg Leu Leu Asp Ser Leu Leu Thr Ala Val Arg Asp                 170 175 180 taaggctctg aaatactaat gag 666 <210> 40 <211> 181 <212> PRT <213> Corynebacterium glutamicum <400> 40 Met Lys Ile Gly Val Ile Leu Gly Ser Ile Arg Glu Gly Arg Phe Gly   1 5 10 15 Gln Gly Val Ala Asp Trp Val Met Glu Gln Ile Gly Ala Tyr Asp Ala              20 25 30 Pro Asp Val Glu Phe Glu Leu Ile Asp Leu Lys Ala Phe Asn Val Pro          35 40 45 Leu Leu Glu Ser Ala Thr Val Pro Gly Ser Ala Asp Lys Gln Tyr Asp      50 55 60 Asp Pro Arg Val Thr Ala Trp Ser Gln Ala Ile Asp Ala Cys Asp Ala  65 70 75 80 Phe Leu Phe Ile Thr Pro Glu Tyr Asn His Gly Val Pro Gly Ala Phe                  85 90 95 Lys Asn Ala Tyr Asp Ile Leu Gly Asn Glu Trp Leu Asn Lys Thr Val             100 105 110 Gly Phe Ile Ser Tyr Gly Ala Val Glu Gly Ile Arg Val Val Glu Gln         115 120 125 Trp Arg Gln Ile Val Ala Thr Phe Asn Met Tyr Asp Ile Arg Ser Gln     130 135 140 Leu Ser Phe Ser Thr Phe Thr Glu Asn Asn Asn Gly Thr Phe Ala Pro 145 150 155 160 Asn Asp Arg Arg Pro Gly Glu Leu Ile Arg Leu Leu Asp Ser Leu Leu                 165 170 175 Thr Ala Val Arg Asp             180 <210> 41 <211> 375 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (375) <223> RXN02809 <400> 41 aac ctc tcc gtc cca gca gca cta acc aac gcc ctt tcc tac ctc tcc 48 Asn Leu Ser Val Pro Ala Ala Leu Thr Asn Ala Leu Ser Tyr Leu Ser   1 5 10 15 gca gag tgg aac aac aag gct gca ggc atc gtc tcc tac ggc tcc gca 96 Ala Glu Trp Asn Asn Lys Ala Ala Gly Ile Val Ser Tyr Gly Ser Ala              20 25 30 atg ggc gtt cgc gca gct gag cac ctc cgc ggc atc ctt tcc gag ctt 144 Met Gly Val Arg Ala Ala Glu His Leu Arg Gly Ile Leu Ser Glu Leu          35 40 45 cag atc gca cac gtt caa aag acc ggc ctg ctg agc atc ttc acc gac 192 Gln Ile Ala His Val Gln Lys Thr Gly Leu Leu Ser Ile Phe Thr Asp      50 55 60 ttc gaa tac cct aac ttc aag cct tcc gag cag ggc atc tcc tct gtg 240 Phe Glu Tyr Pro Asn Phe Lys Pro Ser Glu Gln Gly Ile Ser Ser Val  65 70 75 80 gac gct atg ctt gag cag ctt gtt gtc tgg acc aag gca atg tcc acc 288 Asp Ala Met Leu Glu Gln Leu Val Val Trp Thr Lys Ala Met Ser Thr                  85 90 95 att cgc gag tct gcg aac gtc tat cac tta aga acc cct cac aaa agt 336 Ile Arg Glu Ser Ala Asn Val Tyr His Leu Arg Thr Pro His Lys Ser             100 105 110 ggc gag ctc ccc gac tgg gac tcg cct ctt ttc gta ttc 375 Gly Glu Leu Pro Asp Trp Asp Ser Pro Leu Phe Val Phe         115 120 125 <210> 42 <211> 125 <212> PRT <213> Corynebacterium glutamicum <400> 42 Asn Leu Ser Val Pro Ala Ala Leu Thr Asn Ala Leu Ser Tyr Leu Ser   1 5 10 15 Ala Glu Trp Asn Asn Lys Ala Ala Gly Ile Val Ser Tyr Gly Ser Ala              20 25 30 Met Gly Val Arg Ala Ala Glu His Leu Arg Gly Ile Leu Ser Glu Leu          35 40 45 Gln Ile Ala His Val Gln Lys Thr Gly Leu Leu Ser Ile Phe Thr Asp      50 55 60 Phe Glu Tyr Pro Asn Phe Lys Pro Ser Glu Gln Gly Ile Ser Ser Val  65 70 75 80 Asp Ala Met Leu Glu Gln Leu Val Val Trp Thr Lys Ala Met Ser Thr                  85 90 95 Ile Arg Glu Ser Ala Asn Val Tyr His Leu Arg Thr Pro His Lys Ser             100 105 110 Gly Glu Leu Pro Asp Trp Asp Ser Pro Leu Phe Val Phe         115 120 125 <210> 43 <211> 273 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (273) <223> FRXA02809 <400> 43 gca gca cta acc aac gcc ctt tcc tac ctc tcc gca gag tgg aac aac 48 Ala Ala Leu Thr Asn Ala Leu Ser Tyr Leu Ser Ala Glu Trp Asn Asn   1 5 10 15 aag gct gca ggc atc gtc tcc tac ggc tcc gca atg ggc gtt cgc gca 96 Lys Ala Ala Gly Ile Val Ser Tyr Gly Ser Ala Met Gly Val Arg Ala              20 25 30 gct gag cac ctc cgc ggc atc ctt tcc gag ctt cag atc gca cac gtt 144 Ala Glu His Leu Arg Gly Ile Leu Ser Glu Leu Gln Ile Ala His Val          35 40 45 caa aag acc ggc ctg ctg agc atc ttc acc gac ttc gaa tac cct aac 192 Gln Lys Thr Gly Leu Leu Ser Ile Phe Thr Asp Phe Glu Tyr Pro Asn      50 55 60 ttc aag cct tcc gag cag ggc atc tcc tct gtg gac gct atg ctt gag 240 Phe Lys Pro Ser Glu Gln Gly Ile Ser Ser Val Asp Ala Met Leu Glu  65 70 75 80 cag ctt gtt gtc tgg acc aag gca atg tcc acc 273 Gln Leu Val Val Trp Thr Lys Ala Met Ser Thr                  85 90 <210> 44 <211> 91 <212> PRT <213> Corynebacterium glutamicum <400> 44 Ala Ala Leu Thr Asn Ala Leu Ser Tyr Leu Ser Ala Glu Trp Asn Asn   1 5 10 15 Lys Ala Ala Gly Ile Val Ser Tyr Gly Ser Ala Met Gly Val Arg Ala              20 25 30 Ala Glu His Leu Arg Gly Ile Leu Ser Glu Leu Gln Ile Ala His Val          35 40 45 Gln Lys Thr Gly Leu Leu Ser Ile Phe Thr Asp Phe Glu Tyr Pro Asn      50 55 60 Phe Lys Pro Ser Glu Gln Gly Ile Ser Ser Val Asp Ala Met Leu Glu  65 70 75 80 Gln Leu Val Val Trp Thr Lys Ala Met Ser Thr                  85 90 <210> 45 <211> 5745 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (5722) <223> RXN00113 <400> 45 tctgcgcatc ccactcgagg agctggcaaa cggccgcacc atcgatgttg aggcacgcac 60 cgactccatc gaagagtccg catccggccg tatcgttacc gtg cgc atc gtg ctc 115                                             Val Arg Ile Val Leu                                               1 5 acc acc gaa ggc gaa gta gca gcc aag ctg gtt acc cgc ttc gca att 163 Thr Thr Glu Gly Glu Val Ala Ala Lys Leu Val Thr Arg Phe Ala Ile                  10 15 20 cgt gga cgc atc acc acc aac gaa atg gct gca cca gca gat tcc tac 211 Arg Gly Arg Ile Thr Thr Asn Glu Met Ala Ala Pro Ala Asp Ser Tyr              25 30 35 ggc gca cgc gac gaa gtt gtc gag gca acc cct cgt tcc ttc atc cgc 259 Gly Ala Arg Asp Glu Val Val Glu Ala Thr Pro Arg Ser Phe Ile Arg          40 45 50 cag gca act gtt tct gca cct gca gac atg acc cca ttc gcc atg gtt 307 Gln Ala Thr Val Ser Ala Pro Ala Asp Met Thr Pro Phe Ala Met Val      55 60 65 tct ggt gac tac aac cca att cac acc tct gac aac gct gca aag ctt 355 Ser Gly Asp Tyr Asn Pro Ile His Thr Ser Asp Asn Ala Ala Lys Leu  70 75 80 85 gtt ggc ctg gac gca gct ctt gtc cac ggc atg tgg ctg tcc gct acc 403 Val Gly Leu Asp Ala Ala Leu Val His Gly Met Trp Leu Ser Ala Thr                  90 95 100 gca cag cac ctc gct ggt ctt ggc tct gag gtc att ggt tgg acc tac 451 Ala Gln His Leu Ala Gly Leu Gly Ser Glu Val Ile Gly Trp Thr Tyr             105 110 115 tcc atg tac ggc atg gtt caa ctc aac gac gtt gtt gac atc acc gtc 499 Ser Met Tyr Gly Met Val Gln Leu Asn Asp Val Val Asp Ile Thr Val         120 125 130 gag cgt gtt ggc cgc gca ggt ctg aag cct gca tac gag gtc acc tgc 547 Glu Arg Val Gly Arg Ala Gly Leu Lys Pro Ala Tyr Glu Val Thr Cys     135 140 145 cgc att gat ggc aac gtt gtc tcc cgc gga cag gca ctg ctc aag gct 595 Arg Ile Asp Gly Asn Val Val Ser Arg Gly Gln Ala Leu Leu Lys Ala 150 155 160 165 cct tcc acc gct tat gtt tac cca agc cag ggc atc cag gct aag ggc 643 Pro Ser Thr Ala Tyr Val Tyr Pro Ser Gln Gly Ile Gln Ala Lys Gly                 170 175 180 atg ggc caa ggc gat cgc acc gca agc gca gag gct cgc gct gtg tgg 691 Met Gly Gln Gly Asp Arg Thr Ala Ser Ala Glu Ala Arg Ala Val Trp             185 190 195 gag cgt gca gat gca cac acc cgc gca aac ctg ggc ttc tcc atc cag 739 Glu Arg Ala Asp Ala His Thr Arg Ala Asn Leu Gly Phe Ser Ile Gln         200 205 210 cag gtc att gat gaa aac cca act gag ctg aag gtc ggg gac acc acc 787 Gln Val Ile Asp Glu Asn Pro Thr Glu Leu Lys Val Gly Asp Thr Thr     215 220 225 ttc gtg cac cca gct ggg gtt ttg aac ctc acc cag ttc acg cag gtc 835 Phe Val His Pro Ala Gly Val Leu Asn Leu Thr Gln Phe Thr Gln Val 230 235 240 245 gcg ctc gcc gtg gtt gcc tac gct cag acc gag cgc ctc aag gct gca 883 Ala Leu Ala Val Val Ala Tyr Ala Gln Thr Glu Arg Leu Lys Ala Ala                 250 255 260 aac gca att gtc gac ggc tcc ctc tac gca ggc cac tcc ctc ggc gag 931 Asn Ala Ile Val Asp Gly Ser Leu Tyr Ala Gly His Ser Leu Gly Glu             265 270 275 tac acc gca ctg gca tcc ttg ggc aac atc ttc gaa ctc gaa ggc gtc 979 Tyr Thr Ala Leu Ala Ser Leu Gly Asn Ile Phe Glu Leu Glu Gly Val         280 285 290 atc gac gtt gtg ttc tcc cgc ggt tcc gca atg cac tcc ctg gtt cca 1027 Ile Asp Val Val Phe Ser Arg Gly Ser Ala Met His Ser Leu Val Pro     295 300 305 cgt gat gag aag ggc cgt tcc aac tac ggt ctt gcc gca ttc cgt ccg 1075 Arg Asp Glu Lys Gly Arg Ser Asn Tyr Gly Leu Ala Ala Phe Arg Pro 310 315 320 325 aac atg atc aac gtt gca gcc acc gag gtg gag aac tgg gtt gac cgt 1123 Asn Met Ile Asn Val Ala Ala Thr Glu Val Glu Asn Trp Val Asp Arg                 330 335 340 gtc gct gaa gaa tcc ggc gaa ttc ctg cag atc gtt aac tac aac gtt 1171 Val Ala Glu Glu Ser Gly Glu Phe Leu Gln Ile Val Asn Tyr Asn Val             345 350 355 gat ggc cag cag tac gca gtc gca ggt acc ttg gct ggc ctg aag gcc 1219 Asp Gly Gln Gln Tyr Ala Val Ala Gly Thr Leu Ala Gly Leu Lys Ala         360 365 370 ctc aag gct tct gca tct gca aac cca cgt gct tac gtg aac att cca 1267 Leu Lys Ala Ser Ala Ser Ala Asn Pro Arg Ala Tyr Val Asn Ile Pro     375 380 385 ggc att gac gtg cca ttc cac tcc agc gtc ctg cgc cca ggc gtt cct 1315 Gly Ile Asp Val Pro Phe His Ser Ser Val Leu Arg Pro Gly Val Pro 390 395 400 405 gct ttc gca gag aag ctg gac gag ctg ctg cca gag acc atc gac att 1363 Ala Phe Ala Glu Lys Leu Asp Glu Leu Leu Pro Glu Thr Ile Asp Ile                 410 415 420 gat gct ctt cgc ggc cgc tac atc ccg aac ctg gtt gct cgt cct ttc 1411 Asp Ala Leu Arg Gly Arg Tyr Ile Pro Asn Leu Val Ala Arg Pro Phe             425 430 435 gag ctc acc cag agc ttc gtg gat gcc atc ctt gct gtt gtt cca tcc 1459 Glu Leu Thr Gln Ser Phe Val Asp Ala Ile Leu Ala Val Val Pro Ser         440 445 450 gag cgc ctc aag ggc atc aag gtg gag gac acc gac gag aac acc ctg 1507 Glu Arg Leu Lys Gly Ile Lys Val Glu Asp Thr Asp Glu Asn Thr Leu     455 460 465 gca cgt ctg ctc ctc atc gag ctg ctg tct tgg cag ttc gca tcc cct 1555 Ala Arg Leu Leu Leu Ile Glu Leu Leu Ser Trp Gln Phe Ala Ser Pro 470 475 480 485 gtg cgt tgg atc gaa acc cag gct ctg atc atc gat acc gtc gat cag 1603 Val Arg Trp Ile Glu Thr Gln Ala Leu Ile Ile Asp Thr Val Asp Gln                 490 495 500 atc atc gag gtc ggc ttg gca gca tcg cca acc ctg acc aac ctg gca 1651 Ile Ile Glu Val Gly Leu Ala Ala Ser Pro Thr Leu Thr Asn Leu Ala             505 510 515 ctg cgc acc atg gat gtc att ggc aag tcc cgc cca gta ttc aac gtg 1699 Leu Arg Thr Met Asp Val Ile Gly Lys Ser Arg Pro Val Phe Asn Val         520 525 530 gag cgc gac cag gac acc gtt atg ctc aac gat gtt cgc cag gca cct 1747 Glu Arg Asp Gln Asp Thr Val Met Leu Asn Asp Val Arg Gln Ala Pro     535 540 545 gtt gct gag gtt gaa gaa gaa gca gtt gag gaa gca cct gca gca gcc 1795 Val Ala Glu Val Glu Glu Glu Ala Val Glu Glu Ala Pro Ala Ala Ala 550 555 560 565 gca gct cca gca gct gag gca cca gtt gct gca gct cca gta gcc gca 1843 Ala Ala Pro Ala Ala Glu Ala Pro Val Ala Ala Ala Pro Val Ala Ala                 570 575 580 gcc gca cct gca cct gtt gga aac gca cct gaa ctg aag ttc aac gct 1891 Ala Ala Pro Ala Pro Val Gly Asn Ala Pro Glu Leu Lys Phe Asn Ala             585 590 595 gcc aat gcc atc atg gtt ctc ttc gct gtc cag aac aag atc aac att 1939 Ala Asn Ala Ile Met Val Leu Phe Ala Val Gln Asn Lys Ile Asn Ile         600 605 610 gat cag atc acc gca gcg gat acc tct gag acc ctg acc aac ggt gtg 1987 Asp Gln Ile Thr Ala Ala Asp Thr Ser Glu Thr Leu Thr Asn Gly Val     615 620 625 tcc tca cgc cgt aac cag atg ctc atg gac atg tcc acc gag ctg tcc 2035 Ser Ser Arg Arg Asn Gln Met Leu Met Asp Met Ser Thr Glu Leu Ser 630 635 640 645 gtc cca acc atc gac ggc gca gct gac gct gac gta gct acc ctg cag 2083 Val Pro Thr Ile Asp Gly Ala Ala Asp Ala Asp Val Ala Thr Leu Gln                 650 655 660 gga cgt gtt gtc acc gca gct cct ggc tac aag cct ttc gga cca gtt 2131 Gly Arg Val Val Thr Ala Ala Pro Gly Tyr Lys Pro Phe Gly Pro Val             665 670 675 ctt tcc gag acc gtt cgt gca cgt ctt cgc gca ctg acc ggt gca gca 2179 Leu Ser Glu Thr Val Arg Ala Arg Leu Arg Ala Leu Thr Gly Ala Ala         680 685 690 ggt ctg aag acc tcc tac atc ggc gat cgc gtg acc ggc acc tgg gga 2227 Gly Leu Lys Thr Ser Tyr Ile Gly Asp Arg Val Thr Gly Thr Trp Gly     695 700 705 ctt cca gaa agc tgg acc gca cac gtt gag gtt gaa ttg ctg ctg ggc 2275 Leu Pro Glu Ser Trp Thr Ala His Val Glu Val Glu Leu Leu Leu Gly 710 715 720 725 acc cgc gaa ggc gag tcc gtc cgc ggc ggc aac ctg ggt agc ctg cct 2323 Thr Arg Glu Gly Glu Ser Val Arg Gly Gly Asn Leu Gly Ser Leu Pro                 730 735 740 gct aac gca tcc agc aag ggc gac gtc gat gcg ctt atc gac gca gcc 2371 Ala Asn Ala Ser Ser Lys Gly Asp Val Asp Ala Leu Ile Asp Ala Ala             745 750 755 gtg cag aat gtt gct gca gcc aac ggc acc agc gtc tcc atg tcc tcc 2419 Val Gln Asn Val Ala Ala Ala Asn Gly Thr Ser Val Ser Met Ser Ser         760 765 770 ggc ggt gca gct tca ggt ggc gga gtt gtt gat tcc gca gca ctt gat 2467 Gly Gly Ala Ala Ser Gly Gly Gly Val Val Asp Ser Ala Ala Leu Asp     775 780 785 gcc tac gca tcc acc gtc act ggt gaa gaa ggc gtc ctg gca aac gtt 2515 Ala Tyr Ala Ser Thr Val Thr Gly Glu Glu Gly Val Leu Ala Asn Val 790 795 800 805 gct cgc ggc atc ctg tct cag ctt ggt ctc gac acc aag gac gag gtt 2563 Ala Arg Gly Ile Leu Ser Gln Leu Gly Leu Asp Thr Lys Asp Glu Val                 810 815 820 gaa ggc gca gag atc gac acc gaa ctc tac gac gct gtc gaa gca gaa 2611 Glu Gly Ala Glu Ile Asp Thr Glu Leu Tyr Asp Ala Val Glu Ala Glu             825 830 835 ctg ggc acc ggc tgg ctg aag ctt gtc acc cca gtg ttc tcc gct gat 2659 Leu Gly Thr Gly Trp Leu Lys Leu Val Thr Pro Val Phe Ser Ala Asp         840 845 850 cgt gcg atc ttg ttc gac gac cgt tgg gca tct gca cgt gaa gat ctg 2707 Arg Ala Ile Leu Phe Asp Asp Arg Trp Ala Ser Ala Arg Glu Asp Leu     855 860 865 gca cgc ctt gcc aac ggc gag gat att gcc gtc gag cgc ttt gct gga 2755 Ala Arg Leu Ala Asn Gly Glu Asp Ile Ala Val Glu Arg Phe Ala Gly 870 875 880 885 acg ggg gag acc gtc gtc aag caa gct gca tgg tgg gct gag cac gtt 2803 Thr Gly Glu Thr Val Val Lys Gln Ala Ala Trp Trp Ala Glu His Val                 890 895 900 gaa gac acc gct ctc gct gca acc ctg aag cag gtt tcc gag gtg gct 2851 Glu Asp Thr Ala Leu Ala Ala Thr Leu Lys Gln Val Ser Glu Val Ala             905 910 915 gcg aag cca gcc aac gag cca cac atc gac gat gtt gcg ctg gtt acc 2899 Ala Lys Pro Ala Asn Glu Pro His Ile Asp Asp Val Ala Leu Val Thr         920 925 930 ggt gcg gct cct gag tcg atc gcc ggt gca gtt gcg gct cgc ctg ctg 2947 Gly Ala Ala Pro Glu Ser Ile Ala Gly Ala Val Ala Ala Arg Leu Leu     935 940 945 tcc cag ggc gcg acc gtc att ctc acc gca tcg aac gtc tcc cag gcg 2995 Ser Gln Gly Ala Thr Val Ile Leu Thr Ala Ser Asn Val Ser Gln Ala 950 955 960 965 cgt aag gaa tac gca cgc aag ctc tac gct gcg aac gca acc cct aac 3043 Arg Lys Glu Tyr Ala Arg Lys Leu Tyr Ala Ala Asn Ala Thr Pro Asn                 970 975 980 gca aag ctg tgg att gtt cct gcg aac atg tcc tcc tac cgc gat gtt 3091 Ala Lys Leu Trp Ile Val Pro Ala Asn Met Ser Ser Tyr Arg Asp Val             985 990 995 gat gca gtc atc gat tgg atc ggc aac gag cag cgc gtc acc gtc ggc 3139 Asp Ala Val Ile Asp Trp Ile Gly Asn Glu Gln Arg Val Thr Val Gly         1000 1005 1010 agc acc gtc acc gtg acc aag cca gct ctg acc cca acc ctt gcg tac 3187 Ser Thr Val Thr Val Thr Lys Pro Ala Leu Thr Pro Thr Leu Ala Tyr     1015 1020 1025 cca ttc gca gct cca tcc gta tcc ggt acc ttg gcg gat gca ggc cca 3235 Pro Phe Ala Ala Pro Ser Val Ser Gly Thr Leu Ala Asp Ala Gly Pro 1030 1035 1040 1045 cag gct gaa aac cag gca cgc ctg ctc ctc tgg tcc gtg gag cgc acc 3283 Gln Ala Glu Asn Gln Ala Arg Leu Leu Leu Trp Ser Val Glu Arg Thr                 1050 1055 1060 atc gca gga ctt gca gat ctt gca tcc cgc ggt gtc gat gga cgc gtc 3331 Ile Ala Gly Leu Ala Asp Leu Ala Ser Arg Gly Val Asp Gly Arg Val             1065 1070 1075 cac gtt gta ctc cca ggt tcc ccg aac cgc gga atg ttc ggt ggc gac 3379 His Val Val Leu Pro Gly Ser Pro Asn Arg Gly Met Phe Gly Gly Asp         1080 1085 1090 ggc gct tac ggc gaa gtc aag gct gct ttc gac gcc atc ctt gcc aag 3427 Gly Ala Tyr Gly Glu Val Lys Ala Ala Phe Asp Ala Ile Leu Ala Lys     1095 1100 1105 tgg ggc tcc gag acc ggc tgg cca cag ttt gtc tcc ctc gca cag gca 3475 Trp Gly Ser Glu Thr Gly Trp Pro Gln Phe Val Ser Leu Ala Gln Ala 1110 1115 1120 1125 cgc atc ggc tgg gtc gca ggc acc ggc ctc atg ggt cgc aac gac gtg 3523 Arg Ile Gly Trp Val Ala Gly Thr Gly Leu Met Gly Arg Asn Asp Val                 1130 1135 1140 ctc atc cct gcc gct gaa aag ctg ggc atc cac gtc tac acc cct gaa 3571 Leu Ile Pro Ala Ala Glu Lys Leu Gly Ile His Val Tyr Thr Pro Glu             1145 1150 1155 gag atc tct tcc gaa ctg ctg ggt ctt gca tcc gca gaa tcc cgc gaa 3619 Glu Ile Ser Ser Glu Leu Leu Gly Leu Ala Ser Ala Glu Ser Arg Glu         1160 1165 1170 aag gct ctg gaa gca ccg atc gat tac gac ctg acc ggt gga ctt tcc 3667 Lys Ala Leu Glu Ala Pro Ile Asp Tyr Asp Leu Thr Gly Gly Leu Ser     1175 1180 1185 ggt ggc gta tcc atc gca gca ctg gca gca tcc ctc gag tcc gac gca 3715 Gly Gly Val Ser Ile Ala Ala Leu Ala Ala Ser Leu Glu Ser Asp Ala 1190 1195 1200 1205 gta gag acc acc tct gca gca gaa gac acc atc aag gcg ctt cca tca 3763 Val Glu Thr Thr Ser Ala Ala Glu Asp Thr Ile Lys Ala Leu Pro Ser                 1210 1215 1220 cct aag cac cca gag cag cca gtg ggc acg cca gtt gga gag gtc aag 3811 Pro Lys His Pro Glu Gln Pro Val Gly Thr Pro Val Gly Glu Val Lys             1225 1230 1235 acc gat ctc gaa gac atg gtt gtc atg gtt ggc gtt ggc gaa gtc tcc 3859 Thr Asp Leu Glu Asp Met Val Val Met Val Gly Val Gly Glu Val Ser         1240 1245 1250 tca tgg ggc tcc gga cgt acc cgc ttc gaa gct gag tac ggc atc cag 3907 Ser Trp Gly Ser Gly Arg Thr Arg Phe Glu Ala Glu Tyr Gly Ile Gln     1255 1260 1265 cgc gac ggc tcc gtt gac ctc acc gca gca ggc gtc ctt gag ctt gca 3955 Arg Asp Gly Ser Val Asp Leu Thr Ala Aly Gly Val Leu Glu Leu Ala 1270 1275 1280 1285 tgg atg atg ggt ctg atc tcc tgg agc gaa gat cca aag cca gcc tgg 4003 Trp Met Met Gly Leu Ile Ser Trp Ser Glu Asp Pro Lys Pro Ala Trp                 1290 1295 1300 tac gac gct gac ggc acc gaa gtg cct gaa gaa gag atc tac gag cgc 4051 Tyr Asp Ala Asp Gly Thr Glu Val Pro Glu Glu Glu Ile Tyr Glu Arg             1305 1310 1315 ttc cgc gac gaa gtc atc gca cga tgc ggt gtt cgt gag ctt gtc gac 4099 Phe Arg Asp Glu Val Ile Ala Arg Cys Gly Val Arg Glu Leu Val Asp         1320 1325 1330 gac gca ttc ctc gtc gac ggc ggc tcc ctc gac gca gct gaa gtc ttc 4147 Asp Ala Phe Leu Val Asp Gly Gly Ser Leu Asp Ala Ala Glu Val Phe     1335 1340 1345 ctc gac cgc gac atc tcc ttc tcc gta acc tct gct gaa gaa gca cag 4195 Leu Asp Arg Asp Ile Ser Phe Ser Val Thr Ser Ala Glu Glu Ala Gln 1350 1355 1360 1365 gcc tac gtc gat gca gat gct tcc gtg acc gtt gaa gaa gca gac ggc 4243 Ala Tyr Val Asp Ala Asp Ala Ser Val Thr Val Glu Glu Ala Asp Gly                 1370 1375 1380 gaa tgg atc gtg acc aag aag aag ggc tcc acc tcc ttc gtg cca cgc 4291 Glu Trp Ile Val Thr Lys Lys Lys Gly Ser Thr Ser Phe Val Pro Arg             1385 1390 1395 aag gca acc ctg acc cgc tcc gta gca ggc cag ctg cca acc gac ttc 4339 Lys Ala Thr Leu Thr Arg Ser Val Ala Gly Gln Leu Pro Thr Asp Phe         1400 1405 1410 gac cct gcc aag tgg ggt atc cca gcc tcc atg atc gat gca ctc gac 4387 Asp Pro Ala Lys Trp Gly Ile Pro Ala Ser Met Ile Asp Ala Leu Asp     1415 1420 1425 aac atc gca gcg tgg aac ctg gtc act gca gtc gac gcc ttc ctg tcc 4435 Asn Ile Ala Ala Trp Asn Leu Val Thr Ala Val Asp Ala Phe Leu Ser 1430 1435 1440 1445 tcc ggc ttc agc cca gca gaa ctc ctg cag tcc atc cac cca gct gac 4483 Ser Gly Phe Ser Pro Ala Glu Leu Leu Gln Ser Ile His Pro Ala Asp                 1450 1455 1460 gtg tcc tcc acc cag ggc acc ggt atc ggt ggc atg cag tcc cta cgc 4531 Val Ser Ser Thr Gln Gly Thr Gly Ile Gly Gly Met Gln Ser Leu Arg             1465 1470 1475 aag ctg ttc gtc aac cgc ttc ctc ggc cag gat cgt cca tcc gac atc 4579 Lys Leu Phe Val Asn Arg Phe Leu Gly Gln Asp Arg Pro Ser Asp Ile         1480 1485 1490 ctc cag gag acc ctg cca aac gtt gtg gct gca cac acc atg cag tcc 4627 Leu Gln Glu Thr Leu Pro Asn Val Val Ala Ala His Thr Met Gln Ser     1495 1500 1505 tac gtc ggt ggc tac ggc cag atg atc cac cca gtg gca gca tgt gca 4675 Tyr Val Gly Gly Tyr Gly Gln Met Ile His Pro Val Ala Ala Cys Ala 1510 1515 1520 1525 acc gca gct gtc tcc gtg gaa gaa ggc gtg gac aag atc cgc ctc aac 4723 Thr Ala Ala Val Ser Val Glu Glu Gly Val Asp Lys Ile Arg Leu Asn                 1530 1535 1540 aag gca gat ttc gtt gtc gcc ggt ggt atc gat gac atc cag gtt gaa 4771 Lys Ala Asp Phe Val Val Ala Gly Gly Ile Asp Asp Ile Gln Val Glu             1545 1550 1555 tcc ctg acc ggc ttc ggt gac atg aac gcc acc gca gac acc cag gca 4819 Ser Leu Thr Gly Phe Gly Asp Met Asn Ala Thr Ala Asp Thr Gln Ala         1560 1565 1570 atg ctg gac aag ggc atc gac cca cgc ttc atc tcc cgc gca aac gat 4867 Met Leu Asp Lys Gly Ile Asp Pro Arg Phe Ile Ser Arg Ala Asn Asp     1575 1580 1585 cga cgt cgc gca ggc ttc ctc gaa gca gca ggt ggc ggt acc gtc ctc 4915 Arg Arg Arg Ala Gly Phe Leu Glu Ala Ala Gly Gly Gly Thr Val Leu 1590 1595 1600 1605 ctg gca cgt gca tcc gtt gct gct gaa ctg gga ctg cca gtt ctc gca 4963 Leu Ala Arg Ala Ser Val Ala Ala Glu Leu Gly Leu Pro Val Leu Ala                 1610 1615 1620 gtt gtt gca cac gca cag tcc tac gcc gat ggt gct cac acc tcc atc 5011 Val Val Ala His Ala Gln Ser Tyr Ala Asp Gly Ala His Thr Ser Ile             1625 1630 1635 cca gca ccg gga ctt ggc gca ctg ggt gca gca cgt ggt ggc aag aag 5059 Pro Ala Pro Gly Leu Gly Ala Leu Gly Ala Ala Arg Gly Gly Lys Lys         1640 1645 1650 tcc gta ctt gct cgc gaa ctg aac aaa ttg ggt ctg acc cca gat gac 5107 Ser Val Leu Ala Arg Glu Leu Asn Lys Leu Gly Leu Thr Pro Asp Asp     1655 1660 1665 gtt cgc gtg gtc tcg aag cac gac acc tcc acc aac gcc aac gat cca 5155 Val Arg Val Val Ser Lys His Asp Thr Ser Thr Asn Ala Asn Asp Pro 1670 1675 1680 1685 aac gag tcc gag ctg cac aac ctg ctg tgg aag acc att gga cgc gaa 5203 Asn Glu Ser Glu Leu His Asn Leu Leu Trp Lys Thr Ile Gly Arg Glu                 1690 1695 1700 gcc gac aac ccg atg ttc gtc gtc tcc cag aag tcc ctt acc gga cac 5251 Ala Asp Asn Pro Met Phe Val Val Ser Gln Lys Ser Leu Thr Gly His             1705 1710 1715 tca aag ggc ggt gca gca ctc ttc cag atc ggt gga ctt gtc tcc atc 5299 Ser Lys Gly Gly Ala Ala Leu Phe Gln Ile Gly Gly Leu Val Ser Ile         1720 1725 1730 ctg gaa acc ggc aag ctg cca cag aac gca tcc ctt gac tgc gtt gac 5347 Leu Glu Thr Gly Lys Leu Pro Gln Asn Ala Ser Leu Asp Cys Val Asp     1735 1740 1745 cca gag atg gaa gca aag ggc gag aac ttc gtc tgg ctg cgc aag cca 5395 Pro Glu Met Glu Ala Lys Gly Glu Asn Phe Val Trp Leu Arg Lys Pro 1750 1755 1760 1765 ctg gat ctc ggc gca ggc tcc att aag gcc ggc gta ctt acc tca ctg 5443 Leu Asp Leu Gly Ala Gly Ser Ile Lys Ala Gly Val Leu Thr Ser Leu                 1770 1775 1780 ggc ttc ggc cac gtg gct gca gtc gtc gtg ctg gca acc agc ggc atc 5491 Gly Phe Gly His Val Ala Ala Val Val Val Leu Ala Thr Ser Gly Ile             1785 1790 1795 ttc gag cag gca atg cgc aac gca ggc ctc gac gtc gaa gca tgg cgt 5539 Phe Glu Gln Ala Met Arg Asn Ala Gly Leu Asp Val Glu Ala Trp Arg         1800 1805 1810 gca cgc gca acc cag cgc ctg cgc acc ggt gca aac cgc cta gaa gct 5587 Ala Arg Ala Thr Gln Arg Leu Arg Thr Gly Ala Asn Arg Leu Glu Ala     1815 1820 1825 ggc atg gtt ggc cga gca cca ttg ttc gag cag gtc gac gga cgt cgc 5635 Gly Met Val Gly Arg Ala Pro Leu Phe Glu Gln Val Asp Gly Arg Arg 1830 1835 1840 1845 ctg cca gag cat ggc gct cac caa gca gag atc aac ttg ctt atc gac 5683 Leu Pro Glu His Gly Ala His Gln Ala Glu Ile Asn Leu Leu Ile Asp                 1850 1855 1860 gct gac gct cgc ctc ggt gct gac ggc atc tac cag ggc taaacgttag 5732 Ala Asp Ala Arg Leu Gly Ala Asp Gly Ile Tyr Gln Gly             1865 1870 atagctaaga aag 5745 <210> 46 <211> 1874 <212> PRT <213> Corynebacterium glutamicum <400> 46 Val Arg Ile Val Leu Thr Thr Glu Gly Glu Val Ala Ala Lys Leu Val   1 5 10 15 Thr Arg Phe Ala Ile Arg Gly Arg Ile Thr Thr Asn Glu Met Ala Ala              20 25 30 Pro Ala Asp Ser Tyr Gly Ala Arg Asp Glu Val Val Glu Ala Thr Pro          35 40 45 Arg Ser Phe Ile Arg Gln Ala Thr Val Ser Ala Pro Ala Asp Met Thr      50 55 60 Pro Phe Ala Met Val Ser Gly Asp Tyr Asn Pro Ile His Thr Ser Asp  65 70 75 80 Asn Ala Ala Lys Leu Val Gly Leu Asp Ala Ala Leu Val His Gly Met                  85 90 95 Trp Leu Ser Ala Thr Ala Gln His Leu Ala Gly Leu Gly Ser Glu Val             100 105 110 Ile Gly Trp Thr Tyr Ser Met Tyr Gly Met Val Gln Leu Asn Asp Val         115 120 125 Val Asp Ile Thr Val Glu Arg Val Gly Arg Ala Gly Leu Lys Pro Ala     130 135 140 Tyr Glu Val Thr Cys Arg Ile Asp Gly Asn Val Val Ser Arg Gly Gln 145 150 155 160 Ala Leu Leu Lys Ala Pro Ser Thr Ala Tyr Val Tyr Pro Ser Gln Gly                 165 170 175 Ile Gln Ala Lys Gly Met Gly Gln Gly Asp Arg Thr Ala Ser Ala Glu             180 185 190 Ala Arg Ala Val Trp Glu Arg Ala Asp Ala His Thr Arg Ala Asn Leu         195 200 205 Gly Phe Ser Ile Gln Gln Val Ile Asp Glu Asn Pro Thr Glu Leu Lys     210 215 220 Val Gly Asp Thr Thr Phe Val His Pro Ala Gly Val Leu Asn Leu Thr 225 230 235 240 Gln Phe Thr Gln Val Ala Leu Ala Val Val Ala Tyr Ala Gln Thr Glu                 245 250 255 Arg Leu Lys Ala Ala Asn Ala Ile Val Asp Gly Ser Leu Tyr Ala Gly             260 265 270 His Ser Leu Gly Glu Tyr Thr Ala Leu Ala Ser Leu Gly Asn Ile Phe         275 280 285 Glu Leu Glu Gly Val Ile Asp Val Val Phe Ser Arg Gly Ser Ala Met     290 295 300 His Ser Leu Val Pro Arg Asp Glu Lys Gly Arg Ser Asn Tyr Gly Leu 305 310 315 320 Ala Ala Phe Arg Pro Asn Met Ile Asn Val Ala Ala Thr Glu Val Glu                 325 330 335 Asn Trp Val Asp Arg Val Ala Glu Glu Ser Gly Glu Phe Leu Gln Ile             340 345 350 Val Asn Tyr Asn Val Asp Gly Gln Gln Tyr Ala Val Ala Gly Thr Leu         355 360 365 Ala Gly Leu Lys Ala Leu Lys Ala Ser Ala Ser Ala Asn Pro Arg Ala     370 375 380 Tyr Val Asn Ile Pro Gly Ile Asp Val Pro Phe His Ser Ser Val Leu 385 390 395 400 Arg Pro Gly Val Pro Ala Phe Ala Glu Lys Leu Asp Glu Leu Leu Pro                 405 410 415 Glu Thr Ile Asp Ile Asp Ala Leu Arg Gly Arg Tyr Ile Pro Asn Leu             420 425 430 Val Ala Arg Pro Phe Glu Leu Thr Gln Ser Phe Val Asp Ala Ile Leu         435 440 445 Ala Val Val Pro Ser Glu Arg Leu Lys Gly Ile Lys Val Glu Asp Thr     450 455 460 Asp Glu Asn Thr Leu Ala Arg Leu Leu Leu Ile Glu Leu Leu Ser Trp 465 470 475 480 Gln Phe Ala Ser Pro Val Arg Trp Ile Glu Thr Gln Ala Leu Ile Ile                 485 490 495 Asp Thr Val Asp Gln Ile Glu Val Gly Leu Ala Ala Ser Pro Thr             500 505 510 Leu Thr Asn Leu Ala Leu Arg Thr Met Asp Val Ile Gly Lys Ser Arg         515 520 525 Pro Val Phe Asn Val Glu Arg Asp Gln Asp Thr Val Met Leu Asn Asp     530 535 540 Val Arg Gln Ala Pro Val Ala Glu Val Glu Glu Glu Ala Val Glu Glu 545 550 555 560 Ala Pro Ala Ala Ala Ala Ala Pro Ala Ala Glu Ala Pro Val Ala Ala                 565 570 575 Ala Pro Val Ala Ala Ala Ala Pro Ala Pro Val Gly Asn Ala Pro Glu             580 585 590 Leu Lys Phe Asn Ala Ala Asn Ala Ile Met Val Leu Phe Ala Val Gln         595 600 605 Asn Lys Ile Asn Ile Asp Gln Ile Thr Ala Ala Asp Thr Ser Glu Thr     610 615 620 Leu Thr Asn Gly Val Ser Ser Arg Arg Asn Gln Met Leu Met Asp Met 625 630 635 640 Ser Thr Glu Leu Ser Val Pro Thr Ile Asp Gly Ala Ala Asp Ala Asp                 645 650 655 Val Ala Thr Leu Gln Gly Arg Val Val Thr Ala Ala Pro Gly Tyr Lys             660 665 670 Pro Phe Gly Pro Val Leu Ser Glu Thr Val Arg Ala Arg Leu Arg Ala         675 680 685 Leu Thr Gly Ala Ala Gly Leu Lys Thr Ser Tyr Ile Gly Asp Arg Val     690 695 700 Thr Gly Thr Trp Gly Leu Pro Glu Ser Trp Thr Ala His Val Glu Val 705 710 715 720 Glu Leu Leu Leu Gly Thr Arg Glu Gly Glu Ser Val Arg Gly Gly Asn                 725 730 735 Leu Gly Ser Leu Pro Ala Asn Ala Ser Ser Lys Gly Asp Val Asp Ala             740 745 750 Leu Ile Asp Ala Ala Val Gln Asn Val Ala Ala Ala Asn Gly Thr Ser         755 760 765 Val Ser Met Ser Ser Gly Gly Ala Ala Ser Gly Gly Gly Val Val Asp     770 775 780 Ser Ala Ala Leu Asp Ala Tyr Ala Ser Thr Val Thr Gly Glu Glu Gly 785 790 795 800 Val Leu Ala Asn Val Ala Arg Gly Ile Leu Ser Gln Leu Gly Leu Asp                 805 810 815 Thr Lys Asp Glu Val Glu Gly Ala Glu Ile Asp Thr Glu Leu Tyr Asp             820 825 830 Ala Val Glu Ala Glu Leu Gly Thr Gly Trp Leu Lys Leu Val Thr Pro         835 840 845 Val Phe Ser Ala Asp Arg Ala Ile Leu Phe Asp Asp Arg Trp Ala Ser     850 855 860 Ala Arg Glu Asp Leu Ala Arg Leu Ala Asn Gly Glu Asp Ile Ala Val 865 870 875 880 Glu Arg Phe Ala Gly Thr Gly Glu Thr Val Val Lys Gln Ala Ala Trp                 885 890 895 Trp Ala Glu His Val Glu Asp Thr Ala Leu Ala Ala Thr Leu Lys Gln             900 905 910 Val Ser Glu Val Ala Ala Lys Pro Ala Asn Glu Pro His Ile Asp Asp         915 920 925 Val Ala Leu Val Thr Gly Ala Ala Pro Glu Ser Ile Ala Gly Ala Val     930 935 940 Ala Ala Arg Leu Leu Ser Gln Gly Ala Thr Val Ile Leu Thr Ala Ser 945 950 955 960 Asn Val Ser Gln Ala Arg Lys Glu Tyr Ala Arg Lys Leu Tyr Ala Ala                 965 970 975 Asn Ala Thr Pro Asn Ala Lys Leu Trp Ile Val Pro Ala Asn Met Ser             980 985 990 Ser Tyr Arg Asp Val Asp Ala Val Ile Asp Trp Ile Gly Asn Glu Gln         995 1000 1005 Arg Val Thr Val Gly Ser Thr Val Thr Val Thr Lys Pro Ala Leu Thr     1010 1015 1020 Pro Thr Leu Ala Tyr Pro Phe Ala Ala Pro Ser Val Ser Gly Thr Leu 1025 1030 1035 1040 Ala Asp Ala Gly Pro Gln Ala Glu Asn Gln Ala Arg Leu Leu Leu Trp                 1045 1050 1055 Ser Val Glu Arg Thr Ile Ala Gly Leu Ala Asp Leu Ala Ser Arg Gly             1060 1065 1070 Val Asp Gly Arg Val His Val Val Leu Pro Gly Ser Pro Asn Arg Gly         1075 1080 1085 Met Phe Gly Gly Asp Gly Ala Tyr Gly Glu Val Lys Ala Ala Phe Asp     1090 1095 1100 Ala Ile Leu Ala Lys Trp Gly Ser Glu Thr Gly Trp Pro Gln Phe Val 1105 1110 1115 1120 Ser Leu Ala Gln Ala Arg Ile Gly Trp Val Ala Gly Thr Gly Leu Met                 1125 1130 1135 Gly Arg Asn Asp Val Leu Ile Pro Ala Ala Glu Lys Leu Gly Ile His             1140 1145 1150 Val Tyr Thr Pro Glu Glu Ile Ser Ser Glu Leu Leu Gly Leu Ala Ser         1155 1160 1165 Ala Glu Ser Arg Glu Lys Ala Leu Glu Ala Pro Ile Asp Tyr Asp Leu     1170 1175 1180 Thr Gly Gly Leu Ser Gly Gly Val Ser Ile Ala Ala Leu Ala Ala Ser 1185 1190 1195 1200 Leu Glu Ser Asp Ala Val Glu Thr Thr Ser Ala Ala Glu Asp Thr Ile                 1205 1210 1215 Lys Ala Leu Pro Ser Pro Lys His Pro Glu Gln Pro Val Gly Thr Pro             1220 1225 1230 Val Gly Glu Val Lys Thr Asp Leu Glu Asp Met Val Val Met Val Gly         1235 1240 1245 Val Gly Glu Val Ser Ser Trp Gly Ser Gly Arg Thr Arg Phe Glu Ala     1250 1255 1260 Glu Tyr Gly Ile Gln Arg Asp Gly Ser Val Asp Leu Thr Ala Ala Gly 1265 1270 1275 1280 Val Leu Glu Leu Ala Trp Met Met Gly Leu Ile Ser Trp Ser Glu Asp                 1285 1290 1295 Pro Lys Pro Ala Trp Tyr Asp Ala Asp Gly Thr Glu Val Pro Glu Glu             1300 1305 1310 Glu Ile Tyr Glu Arg Phe Arg Asp Glu Val Ile Ala Arg Cys Gly Val         1315 1320 1325 Arg Glu Leu Val Asp Asp Ala Phe Leu Val Asp Gly Gly Ser Leu Asp     1330 1335 1340 Ala Ala Glu Val Phe Leu Asp Arg Asp Ile Ser Phe Ser Val Thr Ser 1345 1350 1355 1360 Ala Glu Glu Ala Gln Ala Tyr Val Asp Ala Asp Ala Ser Val Thr Val                 1365 1370 1375 Glu Glu Ala Asp Gly Glu Trp Ile Val Thr Lys Lys Lys Gly Ser Thr             1380 1385 1390 Ser Phe Val Pro Arg Lys Ala Thr Leu Thr Arg Ser Val Ala Gly Gln         1395 1400 1405 Leu Pro Thr Asp Phe Asp Pro Ala Lys Trp Gly Ile Pro Ala Ser Met     1410 1415 1420 Ile Asp Ala Leu Asp Asn Ile Ala Ala Trp Asn Leu Val Thr Ala Val 1425 1430 1435 1440 Asp Ala Phe Leu Ser Ser Gly Phe Ser Pro Ala Glu Leu Leu Gln Ser                 1445 1450 1455 Ile His Pro Ala Asp Val Ser Ser Thr Gln Gly Thr Gly Ile Gly Gly             1460 1465 1470 Met Gln Ser Leu Arg Lys Leu Phe Val Asn Arg Phe Leu Gly Gln Asp         1475 1480 1485 Arg Pro Ser Asp Ile Leu Gln Glu Thr Leu Pro Asn Val Val Ala Ala     1490 1495 1500 His Thr Met Gln Ser Tyr Val Gly Gly Tyr Gly Gln Met Ile His Pro 1505 1510 1515 1520 Val Ala Ala Cys Ala Thr Ala Ala Val Ser Val Glu Glu Gly Val Asp                 1525 1530 1535 Lys Ile Arg Leu Asn Lys Ala Asp Phe Val Val Ala Gly Gly Ile Asp             1540 1545 1550 Asp Ile Gln Val Glu Ser Leu Thr Gly Phe Gly Asp Met Asn Ala Thr         1555 1560 1565 Ala Asp Thr Gln Ala Met Leu Asp Lys Gly Ile Asp Pro Arg Phe Ile     1570 1575 1580 Ser Arg Ala Asn Asp Arg Arg Arg Ala Gly Phe Leu Glu Ala Ala Gly 1585 1590 1595 1600 Gly Gly Thr Val Leu Leu Ala Arg Ala Ser Val Ala Ala Glu Leu Gly                 1605 1610 1615 Leu Pro Val Leu Ala Val Val Ala His Ala Gln Ser Tyr Ala Asp Gly             1620 1625 1630 Ala His Thr Ser Ile Pro Ala Pro Gly Leu Gly Ala Leu Gly Ala Ala         1635 1640 1645 Arg Gly Gly Lys Lys Ser Val Leu Ala Arg Glu Leu Asn Lys Leu Gly     1650 1655 1660 Leu Thr Pro Asp Asp Val Arg Val Val Ly Lys His Asp Thr Ser Thr 1665 1670 1675 1680 Asn Ala Asn Asp Pro Asn Glu Ser Glu Leu His Asn Leu Leu Trp Lys                 1685 1690 1695 Thr Ile Gly Arg Glu Ala Asp Asn Pro Met Phe Val Val Ser Gln Lys             1700 1705 1710 Ser Leu Thr Gly His Ser Lys Gly Gly Ala Ala Leu Phe Gln Ile Gly         1715 1720 1725 Gly Leu Val Ser Ile Leu Glu Thr Gly Lys Leu Pro Gln Asn Ala Ser     1730 1735 1740 Leu Asp Cys Val Asp Pro Glu Met Glu Ala Lys Gly Glu Asn Phe Val 1745 1750 1755 1760 Trp Leu Arg Lys Pro Leu Asp Leu Gly Ala Gly Ser Ile Lys Ala Gly                 1765 1770 1775 Val Leu Thr Ser Leu Gly Phe Gly His Val Ala Ala Val Val Val Leu             1780 1785 1790 Ala Thr Ser Gly Ile Phe Glu Gln Ala Met Arg Asn Ala Gly Leu Asp         1795 1800 1805 Val Glu Ala Trp Arg Ala Arg Ala Thr Gln Arg Leu Arg Thr Gly Ala     1810 1815 1820 Asn Arg Leu Glu Ala Gly Met Val Gly Arg Ala Pro Leu Phe Glu Gln 1825 1830 1835 1840 Val Asp Gly Arg Arg Leu Pro Glu His Gly Ala His Gln Ala Glu Ile                 1845 1850 1855 Asn Leu Leu Ile Asp Ala Asp Ala Arg Leu Gly Ala Asp Gly Ile Tyr             1860 1865 1870 Gln gly <210> 47 <211> 3317 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (3294) <223> FRXA00113 <400> 47 gct tca ggt ggc gga gtt gtt gat tcc gca gca ctt gat gcc tac gca 48 Ala Ser Gly Gly Gly Val Val Asp Ser Ala Ala Leu Asp Ala Tyr Ala   1 5 10 15 tcc acc gtc act ggt gaa gaa ggc gtc ctg gca aac gtt gct cgc ggc 96 Ser Thr Val Thr Gly Glu Glu Gly Val Leu Ala Asn Val Ala Arg Gly              20 25 30 att ctg tct cag ctt ggt ctc gac acc aag gac gag gtt gaa ggc gca 144 Ile Leu Ser Gln Leu Gly Leu Asp Thr Lys Asp Glu Val Glu Gly Ala          35 40 45 gag atc gac acc gaa ctc tac gac gct gtc gaa gca gaa ctg ggc acc 192 Glu Ile Asp Thr Glu Leu Tyr Asp Ala Val Glu Ala Glu Leu Gly Thr      50 55 60 ggc tgg ctg aag ctt gtc acc cca gtg ttc tcc gct gat cgt gcg atc 240 Gly Trp Leu Lys Leu Val Thr Pro Val Phe Ser Ala Asp Arg Ala Ile  65 70 75 80 ttg ttc gac gac cgt tgg gca tct gca cgt gaa gat ctg gca cgc ctt 288 Leu Phe Asp Asp Arg Trp Ala Ser Ala Arg Glu Asp Leu Ala Arg Leu                  85 90 95 gcc aac ggc gag gat att gcc gtc gag cgc ttt gct gga acg ggg gag 336 Ala Asn Gly Glu Asp Ile Ala Val Glu Arg Phe Ala Gly Thr Gly Glu             100 105 110 acc gtc gtc aag caa gct gca tgg tgg gct gag cac gtt gaa gac acc 384 Thr Val Val Lys Gln Ala Ala Trp Trp Ala Glu His Val Glu Asp Thr         115 120 125 gct ctc gct gca acc ctg aag cag gtt tcc gag gtg gct gcg aag cca 432 Ala Leu Ala Ala Thr Leu Lys Gln Val Ser Glu Val Ala Ala Lys Pro     130 135 140 gcc aac gag cca cac atc gac gat gtt gcg ctg gtt acc ggt gcg gct 480 Ala Asn Glu Pro His Ile Asp Asp Val Ala Leu Val Thr Gly Ala Ala 145 150 155 160 cct gag tcg atc gcc ggt gca gtt gcg gct cgc ctg ctg tcc cag ggc 528 Pro Glu Ser Ile Ala Gly Ala Val Ala Ala Arg Leu Leu Ser Gln Gly                 165 170 175 gcg acc gtc att ctc acc gca tcg aac gtc tcc cag gcg cgt aag gaa 576 Ala Thr Val Ile Leu Thr Ala Ser Asn Val Ser Gln Ala Arg Lys Glu             180 185 190 tac gca cgc aag ctc tac gct gcg aac gca acc cct aac gca aag ctg 624 Tyr Ala Arg Lys Leu Tyr Ala Ala Asn Ala Thr Pro Asn Ala Lys Leu         195 200 205 tgg att gtt cct gcg aac atg tcc tcc tac cgc gat gtt gat gca gtc 672 Trp Ile Val Pro Ala Asn Met Ser Ser Tyr Arg Asp Val Asp Ala Val     210 215 220 atc gat tgg atc ggc aac gag cag cgc gtc acc gtc ggc agc acc gtc 720 Ile Asp Trp Ile Gly Asn Glu Gln Arg Val Thr Val Gly Ser Thr Val 225 230 235 240 acc gtg acc aag cca gct ctg acc cca acc ctt gcg tac cca ttc gca 768 Thr Val Thr Lys Pro Ala Leu Thr Pro Thr Leu Ala Tyr Pro Phe Ala                 245 250 255 gct cca tcc gta tcc ggt acc ttg gcg gat gca ggc cca cag gct gaa 816 Ala Pro Ser Val Ser Gly Thr Leu Ala Asp Ala Gly Pro Gln Ala Glu             260 265 270 aac cag gca cgc ctg ctc ctc tgg tcc gtg gag cgc acc atc gca gga 864 Asn Gln Ala Arg Leu Leu Leu Trp Ser Val Glu Arg Thr Ile Ala Gly         275 280 285 ctt gca gat ctt gca tcc cgc ggt gtc gat gga cgc gtc cac gtt gta 912 Leu Ala Asp Leu Ala Ser Arg Gly Val Asp Gly Arg Val His Val Val     290 295 300 ctc cca ggt tcc ccg aac cgc gga atg ttc ggt ggc gac ggc gct tac 960 Leu Pro Gly Ser Pro Asn Arg Gly Met Phe Gly Gly Asp Gly Ala Tyr 305 310 315 320 ggc gaa gtc aag gct gct ttc gac gcc atc ctt gcc aag tgg ggc tcc 1008 Gly Glu Val Lys Ala Ala Phe Asp Ala Ile Leu Ala Lys Trp Gly Ser                 325 330 335 gag acc ggc tgg cca cag ttt gtc tcc ctc gca cag gca cgc atc ggc 1056 Glu Thr Gly Trp Pro Gln Phe Val Ser Leu Ala Gln Ala Arg Ile Gly             340 345 350 tgg gtc gca ggc acc ggc ctc atg ggt cgc aac gac gtg ctc atc cct 1104 Trp Val Ala Gly Thr Gly Leu Met Gly Arg Asn Asp Val Leu Ile Pro         355 360 365 gcc gct gaa aag ctg ggc atc cac gtc tac acc cct gaa gag atc tct 1152 Ala Ala Glu Lys Leu Gly Ile His Val Tyr Thr Pro Glu Glu Ile Ser     370 375 380 tcc gaa ctg ctg ggt ctt gca tcc gca gaa tcc cgc gaa aag gct ctg 1200 Ser Glu Leu Leu Gly Leu Ala Ser Ala Glu Ser Arg Glu Lys Ala Leu 385 390 395 400 gaa gca ccg atc gat tac gac ctg acc ggt gga ctt tcc ggt ggc gta 1248 Glu Ala Pro Ile Asp Tyr Asp Leu Thr Gly Gly Leu Ser Gly Gly Val                 405 410 415 tcc atc gca gca ctg gca gca tcc ctc gag tcc gac gca gta gag acc 1296 Ser Ile Ala Ala Leu Ala Ala Ser Leu Glu Ser Asp Ala Val Glu Thr             420 425 430 acc tct gca gca gaa gac acc atc aag gcg ctt cca tca cct aag cac 1344 Thr Ser Ala Ala Glu Asp Thr Ile Lys Ala Leu Pro Ser Pro Lys His         435 440 445 cca gag cag cca gtg ggc acg cca gtt gga gag gtc aag acc gat ctc 1392 Pro Glu Gln Pro Val Gly Thr Pro Val Gly Glu Val Lys Thr Asp Leu     450 455 460 gaa gac atg gtt gtc atg gtt ggc gtt ggc gaa gtc tcc tca tgg ggc 1440 Glu Asp Met Val Val Met Val Gly Val Gly Glu Val Ser Ser Trp Gly 465 470 475 480 tcc gga cgt acc cgc ttc gaa gct gag tac ggc atc cag cgc gac ggc 1488 Ser Gly Arg Thr Arg Phe Glu Ala Glu Tyr Gly Ile Gln Arg Asp Gly                 485 490 495 tcc gtt gac ctc acc gca gca ggc gtc ctt gag ctt gca tgg atg atg 1536 Ser Val Asp Leu Thr Ala Ala Gly Val Leu Glu Leu Ala Trp Met Met             500 505 510 ggt ctg atc tcc tgg agc gaa gat cca aag cca gcc tgg tac gac gct 1584 Gly Leu Ile Ser Trp Ser Glu Asp Pro Lys Pro Ala Trp Tyr Asp Ala         515 520 525 gac ggc acc gaa gtg cct gaa gaa gag atc tac gag cgc ttc cgc gac 1632 Asp Gly Thr Glu Val Pro Glu Glu Glu Ile Tyr Glu Arg Phe Arg Asp     530 535 540 gaa gtc atc gca cga tgc ggt gtt cgt gag ctt gtc gac gac gca ttc 1680 Glu Val Ile Ala Arg Cys Gly Val Arg Glu Leu Val Asp Asp Ala Phe 545 550 555 560 ctc gtc gac ggc ggc tcc ctc gac gca gct gaa gtc ttc ctc gac cgc 1728 Leu Val Asp Gly Gly Ser Leu Asp Ala Ala Glu Val Phe Leu Asp Arg                 565 570 575 gac atc tcc ttc tcc gta acc tct gct gaa gaa gca cag gcc tac gtc 1776 Asp Ile Ser Phe Ser Val Thr Ser Ala Glu Glu Ala Gln Ala Tyr Val             580 585 590 gat gca gat gct tcc gtg acc gtt gaa gaa gca gac ggc gaa tgg atc 1824 Asp Ala Asp Ala Ser Val Thr Val Glu Glu Ala Asp Gly Glu Trp Ile         595 600 605 gtg acc aag aag aag ggc tcc acc tcc ttc gtg cca cgc aag gca acc 1872 Val Thr Lys Lys Lys Gly Ser Thr Ser Phe Val Pro Arg Lys Ala Thr     610 615 620 ctg acc cgc tcc gta gca ggc cag ctg cca acc gac ttc gac cct gcc 1920 Leu Thr Arg Ser Val Ala Gly Gln Leu Pro Thr Asp Phe Asp Pro Ala 625 630 635 640 aag tgg ggt atc cca gcc tcc atg atc gat gca ctc gac aac atc gca 1968 Lys Trp Gly Ile Pro Ala Ser Met Ile Asp Ala Leu Asp Asn Ile Ala                 645 650 655 gcg tgg aac ctg gtc act gca gtc gac gcc ttc ctg tcc tcc ggc ttc 2016 Ala Trp Asn Leu Val Thr Ala Val Asp Ala Phe Leu Ser Ser Gly Phe             660 665 670 agc cca gca gaa ctc ctg cag tcc atc cac cca gct gac gtg tcc tcc 2064 Ser Pro Ala Glu Leu Leu Gln Ser Ile His Pro Ala Asp Val Ser Ser         675 680 685 acc cag ggc acc ggt atc ggt ggc atg cag tcc cta cgc aag ctg ttc 2112 Thr Gln Gly Thr Gly Ile Gly Met Gln Ser Leu Arg Lys Leu Phe     690 695 700 gtc aac cgc ttc ctc ggc cag gat cgt cca tcc gac atc ctc cag gag 2160 Val Asn Arg Phe Leu Gly Gln Asp Arg Pro Ser Asp Ile Leu Gln Glu 705 710 715 720 acc ctg cca aac gtt gtg gct gca cac acc atg cag tcc tac gtc ggt 2208 Thr Leu Pro Asn Val Val Ala Ala His Thr Met Gln Ser Tyr Val Gly                 725 730 735 ggc tac ggc cag atg atc cac cca gtg gca gca tgt gca acc gca gct 2256 Gly Tyr Gly Gln Met Ile His Pro Val Ala Ala Cys Ala Thr Ala Ala             740 745 750 gtc tcc gtg gaa gaa ggc gtg gac aag atc cgc ctc aac aag gca gat 2304 Val Ser Val Glu Glu Gly Val Asp Lys Ile Arg Leu Asn Lys Ala Asp         755 760 765 ttc gtt gtc gcc ggt ggt atc gat gac atc cag gtt gaa tcc ctg acc 2352 Phe Val Val Ala Gly Gly Ile Asp Asp Ile Gln Val Glu Ser Leu Thr     770 775 780 ggc ttc ggt gac atg aac gcc acc gca gac acc cag gca atg ctg gac 2400 Gly Phe Gly Asp Met Asn Ala Thr Ala Asp Thr Gln Ala Met Leu Asp 785 790 795 800 aag ggc atc gac cca cgc ttc atc tcc cgc gca aac gat cga cgt cgc 2448 Lys Gly Ile Asp Pro Arg Phe Ile Ser Arg Ala Asn Asp Arg Arg Arg                 805 810 815 gca ggc ttc ctc gaa gca gca ggt ggc ggt acc gtc ctc ctg gca cgt 2496 Ala Gly Phe Leu Glu Ala Ala Gly Gly Gly Thr Val Leu Leu Ala Arg             820 825 830 gca tcc gtt gct gct gaa ctg gga ctg cca gtt ctc gca gtt gtt gca 2544 Ala Ser Val Ala Ala Glu Leu Gly Leu Pro Val Leu Ala Val Val Ala         835 840 845 cac gca cag tcc tac gcc gat ggt gct cac acc tcc atc cca gca ccg 2592 His Ala Gln Ser Tyr Ala Asp Gly Ala His Thr Ser Ile Pro Ala Pro     850 855 860 gga ctt ggc gca ctg ggt gca gca cgt ggt ggc aag aag tcc gta ctt 2640 Gly Leu Gly Ala Leu Gly Ala Ala Arg Gly Gly Lys Lys Ser Val Leu 865 870 875 880 gct cgc gaa ctg aac aaa ttg ggt ctg acc cca gat gac gtt cgc gtg 2688 Ala Arg Glu Leu Asn Lys Leu Gly Leu Thr Pro Asp Asp Val Arg Val                 885 890 895 gtc tcg aag cac gac acc tcc acc aac gcc aac gat cca aac gag tcc 2736 Val Ser Lys His Asp Thr Ser Thr Asn Ala Asn Asp Pro Asn Glu Ser             900 905 910 gag ctg cac aac ctg ctg tgg aag acc att gga cgc gaa gcc gac aac 2784 Glu Leu His Asn Leu Leu Trp Lys Thr Ile Gly Arg Glu Ala Asp Asn         915 920 925 ccg atg ttc gtc gtc tcc cag aag tcc ctt acc gga cac tca aag ggc 2832 Pro Met Phe Val Val Ser Gln Lys Ser Leu Thr Gly His Ser Lys Gly     930 935 940 ggt gca gca ctc ttc cag atc ggt gga ctt gtc tcc atc ctg gaa acc 2880 Gly Ala Ala Leu Phe Gln Ile Gly Gly Leu Val Ser Ile Leu Glu Thr 945 950 955 960 ggc aag ctg cca cag aac gca tcc ctt gac tgc gtt gac cca gag atg 2928 Gly Lys Leu Pro Gln Asn Ala Ser Leu Asp Cys Val Asp Pro Glu Met                 965 970 975 gaa gca aag ggc gag aac ttc gtc tgg ctg cgc aag cca ctg gat ctc 2976 Glu Ala Lys Gly Glu Asn Phe Val Trp Leu Arg Lys Pro Leu Asp Leu             980 985 990 ggc gca ggc tcc att aag gcc ggc gta ctt acc tca ctg ggc ttc ggc 3024 Gly Ala Gly Ser Ile Lys Ala Gly Val Leu Thr Ser Leu Gly Phe Gly         995 1000 1005 cac gtg gct gca gtc gtc gtg ctg gca acc agc ggc atc ttc gag cag 3072 His Val Ala Ala Val Val Val Leu Ala Thr Ser Gly Ile Phe Glu Gln     1010 1015 1020 gca atg cgc aac gca ggc ctc gac gtc gaa gca tgg cgt gca cgc gca 3120 Ala Met Arg Asn Ala Gly Leu Asp Val Glu Ala Trp Arg Ala Arg Ala 1025 1030 1035 1040 acc cag cgc ctg cgc acc ggt gca aac cgc cta gaa gct ggc atg gtt 3168 Thr Gln Arg Leu Arg Thr Gly Ala Asn Arg Leu Glu Ala Gly Met Val                 1045 1050 1055 ggc cga gca cca ttg ttc gag cag gtc gac gga cgt cgc ctg cca gag 3216 Gly Arg Ala Pro Leu Phe Glu Gln Val Asp Gly Arg Arg Leu Pro Glu             1060 1065 1070 cat ggc gct cac caa gca gag atc aac ttg ctt atc gac gct gac gct 3264 His Gly Ala His Gln Ala Glu Ile Asn Leu Leu Ile Asp Ala Asp Ala         1075 1080 1085 cgc ctc ggt gct gac ggc atc tac cag ggc taaacgttag atagctaaga 3314 Arg Leu Gly Ala Asp Gly Ile Tyr Gln Gly     1090 1095 aag 3317 <210> 48 <211> 1098 <212> PRT <213> Corynebacterium glutamicum <400> 48 Ala Ser Gly Gly Gly Val Val Asp Ser Ala Ala Leu Asp Ala Tyr Ala   1 5 10 15 Ser Thr Val Thr Gly Glu Glu Gly Val Leu Ala Asn Val Ala Arg Gly              20 25 30 Ile Leu Ser Gln Leu Gly Leu Asp Thr Lys Asp Glu Val Glu Gly Ala          35 40 45 Glu Ile Asp Thr Glu Leu Tyr Asp Ala Val Glu Ala Glu Leu Gly Thr      50 55 60 Gly Trp Leu Lys Leu Val Thr Pro Val Phe Ser Ala Asp Arg Ala Ile  65 70 75 80 Leu Phe Asp Asp Arg Trp Ala Ser Ala Arg Glu Asp Leu Ala Arg Leu                  85 90 95 Ala Asn Gly Glu Asp Ile Ala Val Glu Arg Phe Ala Gly Thr Gly Glu             100 105 110 Thr Val Val Lys Gln Ala Ala Trp Trp Ala Glu His Val Glu Asp Thr         115 120 125 Ala Leu Ala Ala Thr Leu Lys Gln Val Ser Glu Val Ala Ala Lys Pro     130 135 140 Ala Asn Glu Pro His Ile Asp Asp Val Ala Leu Val Thr Gly Ala Ala 145 150 155 160 Pro Glu Ser Ile Ala Gly Ala Val Ala Ala Arg Leu Leu Ser Gln Gly                 165 170 175 Ala Thr Val Ile Leu Thr Ala Ser Asn Val Ser Gln Ala Arg Lys Glu             180 185 190 Tyr Ala Arg Lys Leu Tyr Ala Ala Asn Ala Thr Pro Asn Ala Lys Leu         195 200 205 Trp Ile Val Pro Ala Asn Met Ser Ser Tyr Arg Asp Val Asp Ala Val     210 215 220 Ile Asp Trp Ile Gly Asn Glu Gln Arg Val Thr Val Gly Ser Thr Val 225 230 235 240 Thr Val Thr Lys Pro Ala Leu Thr Pro Thr Leu Ala Tyr Pro Phe Ala                 245 250 255 Ala Pro Ser Val Ser Gly Thr Leu Ala Asp Ala Gly Pro Gln Ala Glu             260 265 270 Asn Gln Ala Arg Leu Leu Leu Trp Ser Val Glu Arg Thr Ile Ala Gly         275 280 285 Leu Ala Asp Leu Ala Ser Arg Gly Val Asp Gly Arg Val His Val Val     290 295 300 Leu Pro Gly Ser Pro Asn Arg Gly Met Phe Gly Gly Asp Gly Ala Tyr 305 310 315 320 Gly Glu Val Lys Ala Ala Phe Asp Ala Ile Leu Ala Lys Trp Gly Ser                 325 330 335 Glu Thr Gly Trp Pro Gln Phe Val Ser Leu Ala Gln Ala Arg Ile Gly             340 345 350 Trp Val Ala Gly Thr Gly Leu Met Gly Arg Asn Asp Val Leu Ile Pro         355 360 365 Ala Ala Glu Lys Leu Gly Ile His Val Tyr Thr Pro Glu Glu Ile Ser     370 375 380 Ser Glu Leu Leu Gly Leu Ala Ser Ala Glu Ser Arg Glu Lys Ala Leu 385 390 395 400 Glu Ala Pro Ile Asp Tyr Asp Leu Thr Gly Gly Leu Ser Gly Gly Val                 405 410 415 Ser Ile Ala Ala Leu Ala Ala Ser Leu Glu Ser Asp Ala Val Glu Thr             420 425 430 Thr Ser Ala Ala Glu Asp Thr Ile Lys Ala Leu Pro Ser Pro Lys His         435 440 445 Pro Glu Gln Pro Val Gly Thr Pro Val Gly Glu Val Lys Thr Asp Leu     450 455 460 Glu Asp Met Val Val Met Val Gly Val Gly Glu Val Ser Ser Trp Gly 465 470 475 480 Ser Gly Arg Thr Arg Phe Glu Ala Glu Tyr Gly Ile Gln Arg Asp Gly                 485 490 495 Ser Val Asp Leu Thr Ala Ala Gly Val Leu Glu Leu Ala Trp Met Met             500 505 510 Gly Leu Ile Ser Trp Ser Glu Asp Pro Lys Pro Ala Trp Tyr Asp Ala         515 520 525 Asp Gly Thr Glu Val Pro Glu Glu Glu Ile Tyr Glu Arg Phe Arg Asp     530 535 540 Glu Val Ile Ala Arg Cys Gly Val Arg Glu Leu Val Asp Asp Ala Phe 545 550 555 560 Leu Val Asp Gly Gly Ser Leu Asp Ala Ala Glu Val Phe Leu Asp Arg                 565 570 575 Asp Ile Ser Phe Ser Val Thr Ser Ala Glu Glu Ala Gln Ala Tyr Val             580 585 590 Asp Ala Asp Ala Ser Val Thr Val Glu Glu Ala Asp Gly Glu Trp Ile         595 600 605 Val Thr Lys Lys Lys Gly Ser Thr Ser Phe Val Pro Arg Lys Ala Thr     610 615 620 Leu Thr Arg Ser Val Ala Gly Gln Leu Pro Thr Asp Phe Asp Pro Ala 625 630 635 640 Lys Trp Gly Ile Pro Ala Ser Met Ile Asp Ala Leu Asp Asn Ile Ala                 645 650 655 Ala Trp Asn Leu Val Thr Ala Val Asp Ala Phe Leu Ser Ser Gly Phe             660 665 670 Ser Pro Ala Glu Leu Leu Gln Ser Ile His Pro Ala Asp Val Ser Ser         675 680 685 Thr Gln Gly Thr Gly Ile Gly Met Gln Ser Leu Arg Lys Leu Phe     690 695 700 Val Asn Arg Phe Leu Gly Gln Asp Arg Pro Ser Asp Ile Leu Gln Glu 705 710 715 720 Thr Leu Pro Asn Val Val Ala Ala His Thr Met Gln Ser Tyr Val Gly                 725 730 735 Gly Tyr Gly Gln Met Ile His Pro Val Ala Ala Cys Ala Thr Ala Ala             740 745 750 Val Ser Val Glu Glu Gly Val Asp Lys Ile Arg Leu Asn Lys Ala Asp         755 760 765 Phe Val Val Ala Gly Gly Ile Asp Asp Ile Gln Val Glu Ser Leu Thr     770 775 780 Gly Phe Gly Asp Met Asn Ala Thr Ala Asp Thr Gln Ala Met Leu Asp 785 790 795 800 Lys Gly Ile Asp Pro Arg Phe Ile Ser Arg Ala Asn Asp Arg Arg Arg                 805 810 815 Ala Gly Phe Leu Glu Ala Ala Gly Gly Gly Thr Val Leu Leu Ala Arg             820 825 830 Ala Ser Val Ala Ala Glu Leu Gly Leu Pro Val Leu Ala Val Val Ala         835 840 845 His Ala Gln Ser Tyr Ala Asp Gly Ala His Thr Ser Ile Pro Ala Pro     850 855 860 Gly Leu Gly Ala Leu Gly Ala Ala Arg Gly Gly Lys Lys Ser Val Leu 865 870 875 880 Ala Arg Glu Leu Asn Lys Leu Gly Leu Thr Pro Asp Asp Val Arg Val                 885 890 895 Val Ser Lys His Asp Thr Ser Thr Asn Ala Asn Asp Pro Asn Glu Ser             900 905 910 Glu Leu His Asn Leu Leu Trp Lys Thr Ile Gly Arg Glu Ala Asp Asn         915 920 925 Pro Met Phe Val Val Ser Gln Lys Ser Leu Thr Gly His Ser Lys Gly     930 935 940 Gly Ala Ala Leu Phe Gln Ile Gly Gly Leu Val Ser Ile Leu Glu Thr 945 950 955 960 Gly Lys Leu Pro Gln Asn Ala Ser Leu Asp Cys Val Asp Pro Glu Met                 965 970 975 Glu Ala Lys Gly Glu Asn Phe Val Trp Leu Arg Lys Pro Leu Asp Leu             980 985 990 Gly Ala Gly Ser Ile Lys Ala Gly Val Leu Thr Ser Leu Gly Phe Gly         995 1000 1005 His Val Ala Ala Val Val Val Leu Ala Thr Ser Gly Ile Phe Glu Gln     1010 1015 1020 Ala Met Arg Asn Ala Gly Leu Asp Val Glu Ala Trp Arg Ala Arg Ala 1025 1030 1035 1040 Thr Gln Arg Leu Arg Thr Gly Ala Asn Arg Leu Glu Ala Gly Met Val                 1045 1050 1055 Gly Arg Ala Pro Leu Phe Glu Gln Val Asp Gly Arg Arg Leu Pro Glu             1060 1065 1070 His Gly Ala His Gln Ala Glu Ile Asn Leu Leu Ile Asp Ala Asp Ala         1075 1080 1085 Arg Leu Gly Ala Asp Gly Ile Tyr Gln Gly     1090 1095 <210> 49 <211> 6136 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (6136) <223> RXN03111 <400> 49 cgtgaccgaa ttgagcagga acttcggggc cagccgactg attaaccgct ttggccagga 60 gccttttgcc ttcgctttcg ccggccaagg atatgactgg ttg aag acc ctt cgt 115                                             Leu Lys Thr Leu Arg                                               1 5 gcc gcg gtt gcc gca ggt gca ggc acc aat gtt agt gac atc gtc gag 163 Ala Ala Val Ala Ala Gly Ala Gly Thr Asn Val Ser Asp Ile Val Glu                  10 15 20 cgc gca aat gcg ctg ctt gca cta gtt gca gat gat ctc att ggc acc 211 Arg Ala Asn Ala Leu Leu Ala Leu Val Ala Asp Asp Leu Ile Gly Thr              25 30 35 ctt cca ttt ggt ttc gat cca gtg gct tgg gct aac aac tcc gaa gat 259 Leu Pro Phe Gly Phe Asp Pro Val Ala Trp Ala Asn Asn Ser Glu Asp          40 45 50 cca gct ttc gat act gca caa tct gca gtg agc gtg ccg ggt atc ttt 307 Pro Ala Phe Asp Thr Ala Gln Ser Ala Val Ser Val Pro Gly Ile Phe      55 60 65 gtc tcc cag atc gca acc ctg gat tcc ctt gag gcg cag cgc ctt gat 355 Val Ser Gln Ile Ala Thr Leu Asp Ser Leu Glu Ala Gln Arg Leu Asp  70 75 80 85 gtg gat cag gct gtg tcc agc att ggt cat tcc cag ggc gta ttg ggc 403 Val Asp Gln Ala Val Ser Ser Ile Gly His Ser Gln Gly Val Leu Gly                  90 95 100 gtg cac ctg ctc aat gat gcg act cgt gct gat gaa ctc gtt gcc att 451 Val His Leu Leu Asn Asp Ala Thr Arg Ala Asp Glu Leu Val Ala Ile             105 110 115 gcg cag ttg atc ggt gca gcg atc acc cgc acc gca cgc atg acg ggc 499 Ala Gln Leu Ile Gly Ala Ala Ile Thr Arg Thr Ala Arg Met Thr Gly         120 125 130 ctg atc gcg cag ggc gac aac atg ccg atg ctg tcg atc gcc gga att 547 Leu Ile Ala Gln Gly Asp Asn Met Pro Met Leu Ser Ile Ala Gly Ile     135 140 145 tcc cgc gaa cag ctt cag caa gct atc gac gcg gcc tgc gcc gaa gtc 595 Ser Arg Glu Gln Leu Gln Gln Ala Ile Asp Ala Ala Cys Ala Glu Val 150 155 160 165 cct gcg gag atc cgc ccg gtt atc ggt ctg cgc aac tca cgc gat tct 643 Pro Ala Glu Ile Arg Pro Val Ile Gly Leu Arg Asn Ser Arg Asp Ser                 170 175 180 tat gtt ttg gtt ggc cgc cca gac gac aac gct cgc gtt gtt aag gtc 691 Tyr Val Leu Val Gly Arg Pro Asp Asp Asn Ala Arg Val Val Lys Val             185 190 195 att gag gca atg gct gcc aag gat aag aag gcc att gaa gat aag ctg 739 Ile Glu Ala Met Ala Ala Lys Asp Lys Lys Ala Ile Glu Asp Lys Leu         200 205 210 cgc ggc ggt tcc gcg ttc agc ccc cgt att act ccg ctg aag gtg cag 787 Arg Gly Gly Ser Ala Phe Ser Pro Arg Ile Thr Pro Leu Lys Val Gln     215 220 225 gct gct ttc cat cac cca gct atg aac atg gct gtg gag cag acc gtg 835 Ala Ala Phe His His Pro Ala Met Asn Met Ala Val Glu Gln Thr Val 230 235 240 245 gcg tgg gca acc act gct ggt ttg gat gtg gaa ctc acc cgc gag atc 883 Ala Trp Ala Thr Thr Ala Gly Leu Asp Val Glu Leu Thr Arg Glu Ile                 250 255 260 gcc gct gat gtt ttg gtt aac cct gtc gat tgg gta gca cgc gtc aac 931 Ala Ala Asp Val Leu Val Asn Pro Val Asp Trp Val Ala Arg Val Asn             265 270 275 gaa gcg tat gag gct ggc gct cgc tgg ttc ctc gac gtt gga cca gat 979 Glu Ala Tyr Glu Ala Gly Ala Arg Trp Phe Leu Asp Val Gly Pro Asp         280 285 290 ggt ggc atc gtt aag ctg act gcc aac atc ctt gag ggc cgc ggc gcg 1027 Gly Gly Ile Val Lys Leu Thr Ala Asn Ile Leu Glu Gly Arg Gly Ala     295 300 305 gat tcc ttc tat gtt ggt gac gcc gca ggc cag gcc aag ata ttt gat 1075 Asp Ser Phe Tyr Val Gly Asp Ala Ala Gly Gln Ala Lys Ile Phe Asp 310 315 320 325 gct ggc atg gca cct gaa ctt cca gtg gat tac cag gag ttc gca cca 1123 Ala Gly Met Ala Pro Glu Leu Pro Val Asp Tyr Gln Glu Phe Ala Pro                 330 335 340 cgc gtt gag cac gtt gat gga acc cca cgc ctg gtt acc aag ttc act 1171 Arg Val Glu His Val Asp Gly Thr Pro Arg Leu Val Thr Lys Phe Thr             345 350 355 gag ctg acc ggc cgc acc cca atg atg ctg gct ggc atg acc cca acc 1219 Glu Leu Thr Gly Arg Thr Pro Met Met Leu Ala Gly Met Thr Pro Thr         360 365 370 acc gtt gac cct gcc att gtt gca gcc gct gca aac ggt gga cac tgg 1267 Thr Val Asp Pro Ala Ile Val Ala Ala Ala Ala Asn Gly Gly His Trp     375 380 385 gct gag ctc gct ggt ggc gga cag gtt acc cca gag ctg ctg gaa acc 1315 Ala Glu Leu Ala Gly Gly Gly Gln Val Thr Pro Glu Leu Leu Glu Thr 390 395 400 405 cac atc gca cag ctc acc gac atg ctt gag cca ggt atc aac gcc cag 1363 His Ile Ala Gln Leu Thr Asp Met Leu Glu Pro Gly Ile Asn Ala Gln                 410 415 420 ttc aac tcc atg ttc ttg gat cca tac ctg tgg aag atg cag att ggt 1411 Phe Asn Ser Met Phe Leu Asp Pro Tyr Leu Trp Lys Met Gln Ile Gly             425 430 435 ggc aag cgc ctt gtt cct aag gcc cgc gct aat ggt gca tcc atc gac 1459 Gly Lys Arg Leu Val Pro Lys Ala Arg Ala Asn Gly Ala Ser Ile Asp         440 445 450 ggc atc gtc atc acc gcc ggc att cct gaa aag gat gaa gct gtt gca 1507 Gly Ile Val Ile Thr Ala Gly Ile Pro Glu Lys Asp Glu Ala Val Ala     455 460 465 ttg gtc aag gaa ctg atg cgt gat ggt ttc cct tgg atc gca ttc aag 1555 Leu Val Lys Glu Leu Met Arg Asp Gly Phe Pro Trp Ile Ala Phe Lys 470 475 480 485 cca ggt gcc atc aag cag gtt aac tct gtg ttg gct atc gct aag gaa 1603 Pro Gly Ala Ile Lys Gln Val Asn Ser Val Leu Ala Ile Ala Lys Glu                 490 495 500 gtt cca gaa ctc ccc atc atc att cag att gag ggt ggc gtt gca ggt 1651 Val Pro Glu Leu Pro Ile Ile Ile Gln Ile Glu Gly Gly Val Ala Gly             505 510 515 gga cac cac tct tgg gaa gac ctc gat gag ctg ctg atc gcc acc tac 1699 Gly His His Ser Trp Glu Asp Leu Asp Glu Leu Leu Ile Ala Thr Tyr         520 525 530 ggc aag gtc cgc gca ctg gat aac gtg gtg ctg tgt gtc ggc ggt ggc 1747 Gly Lys Val Arg Ala Leu Asp Asn Val Val Leu Cys Val Gly Gly Gly     535 540 545 att ggc tca cct gag cgc gct gct gat tac gtc acc ggt tcc tgg tcc 1795 Ile Gly Ser Pro Glu Arg Ala Ala Asp Tyr Val Thr Gly Ser Trp Ser 550 555 560 565 act tcc tac ggc ctg cca gct atg cct gtt gat ggc atc ttg gtg ggt 1843 Thr Ser Tyr Gly Leu Pro Ala Met Pro Val Asp Gly Ile Leu Val Gly                 570 575 580 acc gct gcg atg gca acc aag gaa gca acc acc tcc cag gcc gtc aag 1891 Thr Ala Ala Met Ala Thr Lys Glu Ala Thr Thr Ser Gln Ala Val Lys             585 590 595 gaa ctt ctt gtt tcc acc cag ggc tct gat gaa tgg gtt cct gct ggt 1939 Glu Leu Leu Val Ser Thr Gln Gly Ser Asp Glu Trp Val Pro Ala Gly         600 605 610 ggc gca aag aac gga atg gca tct ggc cgt tcc cag ctt ggc gca gac 1987 Gly Ala Lys Asn Gly Met Ala Ser Gly Arg Ser Gln Leu Gly Ala Asp     615 620 625 atc cac gag atc gac aac tcc ttt gct aag gct gga cgc ctt ctt gat 2035 Ile His Glu Ile Asp Asn Ser Phe Ala Lys Ala Gly Arg Leu Leu Asp 630 635 640 645 gag gtt gca ggc gat gag acg gct gtg cag gcg cgc cgg gat gag atc 2083 Glu Val Ala Gly Asp Glu Thr Ala Val Gln Ala Arg Arg Asp Glu Ile                 650 655 660 att gaa gcg att ggc aag acc gcc aag gtg tac ttc ggt gac atc gga 2131 Ile Glu Ala Ile Gly Lys Thr Ala Lys Val Tyr Phe Gly Asp Ile Gly             665 670 675 tcc atg act tac gag cag tgg ctc aac cgc tac ctc gag ctg tct ggc 2179 Ser Met Thr Tyr Glu Gln Trp Leu Asn Arg Tyr Leu Glu Leu Ser Gly         680 685 690 cct gtt gat ggt cag tgg att gat gct tcc tgg gct gca cgt ttt gcc 2227 Pro Val Asp Gly Gln Trp Ile Asp Ala Ser Trp Ala Ala Arg Phe Ala     695 700 705 cag atg ctg gag cgt gcc gag gcg cgt ttg atc gag cag gat cat ggc 2275 Gln Met Leu Glu Arg Ala Glu Ala Arg Leu Ile Glu Gln Asp His Gly 710 715 720 725 caa ttt gag cca agc ctg acg gtg gag gat ggc gtc gac aag ctt gtt 2323 Gln Phe Glu Pro Ser Leu Thr Val Glu Asp Gly Val Asp Lys Leu Val                 730 735 740 gct gct tac ccg cat gcc gca acc gac ctg ctc acc ccg gct gat gtc 2371 Ala Ala Tyr Pro His Ala Ala Thr Asp Leu Leu Thr Pro Ala Asp Val             745 750 755 gcc tgg ttc ttg ggc ctg tgc cgc acg ccg ggc aag cct gtg aac ttt 2419 Ala Trp Phe Leu Gly Leu Cys Arg Thr Pro Gly Lys Pro Val Asn Phe         760 765 770 gtg ccc gtc att gat aag gac gtg cgt cgc tgg tgg cgc tcg gac tcc 2467 Val Pro Val Ile Asp Lys Asp Val Arg Arg Trp Trp Arg Ser Asp Ser     775 780 785 ctg tgg cag tcc cac gat gat cgc tac acc gct gat cag gtg gct att 2515 Leu Trp Gln Ser His Asp Asp Arg Tyr Thr Ala Asp Gln Val Ala Ile 790 795 800 805 atc cct ggt gtc gtc gcc gtt gct ggc atc acc aag gcc aac gaa cct 2563 Ile Pro Gly Val Val Ala Val Ala Gly Ile Thr Lys Ala Asn Glu Pro                 810 815 820 gtc gct gac ctg ctt gat cgc ttt gtc gac gcc acc atc gag cgc atc 2611 Val Ala Asp Leu Leu Asp Arg Phe Val Asp Ala Thr Ile Glu Arg Ile             825 830 835 gat gag cac gat tcc cgc tcc cgc gac atc atg ggc aaa gtg ctt tcc 2659 Asp Glu His Asp Ser Arg Ser Arg Asp Ile Met Gly Lys Val Leu Ser         840 845 850 tca cct ggc aca ttc tgg gct ggc cgc aac atc cca tcg gtg atc cac 2707 Ser Pro Gly Thr Phe Trp Ala Gly Arg Asn Ile Pro Ser Val Ile His     855 860 865 agc ctt ggg cat gct gac aag tgg tcc cgc tcc gaa ttc gaa gca ttc 2755 Ser Leu Gly His Ala Asp Lys Trp Ser Arg Ser Glu Phe Glu Ala Phe 870 875 880 885 cat agc cca acc ggc gcc aac ttg gtg tac gaa gac gcc gag cac gcg 2803 His Ser Pro Thr Gly Ala Asn Leu Val Tyr Glu Asp Ala Glu His Ala                 890 895 900 atg ctg act gtg cct ttg gcg ggt tcc acc gca ttc ggc acc acc gct 2851 Met Leu Thr Val Pro Leu Ala Gly Ser Thr Ala Phe Gly Thr Thr Ala             905 910 915 gag ctg aaa atc cgt ttc acc agc ccc atc gac gct ctg cca agc gct 2899 Glu Leu Lys Ile Arg Phe Thr Ser Pro Ile Asp Ala Leu Pro Ser Ala         920 925 930 gtc cca ctg gtc acc cag gaa gac gct gaa gcc gcg atg ggt gaa ctg 2947 Val Pro Leu Val Thr Gln Glu Asp Ala Glu Ala Ala Met Gly Glu Leu     935 940 945 acc cgc atc gca gct ggc ggc acc ctg gca act gtg aac aat ggc acc 2995 Thr Arg Ile Ala Ala Gly Gly Thr Leu Ala Thr Val Asn Asn Gly Thr 950 955 960 965 gct acc tgg gaa acc tcc gtc gat gcc ggc gtc atc gct gac tac aac 3043 Ala Thr Trp Glu Thr Ser Val Asp Ala Gly Val Ile Ala Asp Tyr Asn                 970 975 980 aac gtc acc gca ggc tac ctg cca gca tcc gtt gtt cct gca cac acc 3091 Asn Val Thr Ala Gly Tyr Leu Pro Ala Ser Val Val Pro Ala His Thr             985 990 995 gca cct gac gtg ctg gtt ggc cgc gca tgg cca gca gtt ttc gct gcc 3139 Ala Pro Asp Val Leu Val Gly Arg Ala Trp Pro Ala Val Phe Ala Ala         1000 1005 1010 gta aag tcc gca gtc atc cca ggc acc gat tcc gca tcc gtt gtg gaa 3187 Val Lys Ser Ala Val Ile Pro Gly Thr Asp Ser Ala Ser Val Val Glu     1015 1020 1025 ggc atg ctg tcc ctg gtt cac ctg gag cac cac att gtg ctc aag tcc 3235 Gly Met Leu Ser Leu Val His Leu Glu His His Ile Val Leu Lys Ser 1030 1035 1040 1045 gat gtc cca acc gac ggc gcg ctg aag gtt tcc gcg act gcc gat gag 3283 Asp Val Pro Thr Asp Gly Ala Leu Lys Val Ser Ala Thr Ala Asp Glu                 1050 1055 1060 gta gtc gat acc gac ctg ggt cgc ctc gtg atc gtg cgc gca gaa atc 3331 Val Val Asp Thr Asp Leu Gly Arg Leu Val Ile Val Arg Ala Glu Ile             1065 1070 1075 gcc gac gca gaa ggc aac ctg att gct acg ttg gct gag cgt ttc gcg 3379 Ala Asp Ala Glu Gly Asn Leu Ile Ala Thr Leu Ala Glu Arg Phe Ala         1080 1085 1090 atc cgc gga cgc aag ggc aac gct gtc gca cgc acc aac acc tcc gca 3427 Ile Arg Gly Arg Lys Gly Asn Ala Val Ala Arg Thr Asn Thr Ser Ala     1095 1100 1105 ctg cca acc acc gtg gac acc cca cgc tca gct cgc gca gtg gca acc 3475 Leu Pro Thr Thr Val Asp Thr Pro Arg Ser Ala Arg Ala Val Ala Thr 1110 1115 1120 1125 gtt gtt gca cct gaa tcc atg cgc cca ttc gct gtg atc tcc ggt gac 3523 Val Val Ala Pro Glu Ser Met Arg Pro Phe Ala Val Ile Ser Gly Asp                 1130 1135 1140 cgc aac cca att cac gtc tct gat gtt gcg gct tcc ctg gct ggt ctg 3571 Arg Asn Pro Ile His Val Ser Asp Val Ala Ala Ser Leu Ala Gly Leu             1145 1150 1155 cca ggt gtg atc gtg cac ggc atg tgg acc tct gcc atc ggt gaa ctg 3619 Pro Gly Val Ile Val His Gly Met Trp Thr Ser Ala Ile Gly Glu Leu         1160 1165 1170 atc gcc ggt gca gca ttc aac gat gag cag atc caa act ccc gca gcc 3667 Ile Ala Gly Ala Ala Phe Asn Asp Glu Gln Ile Gln Thr Pro Ala Ala     1175 1180 1185 aag gtc gtg gaa tac acc gca acc atg ctg gca cca gtt ctt cca ggt 3715 Lys Val Val Glu Tyr Thr Ala Thr Met Leu Ala Pro Val Leu Pro Gly 1190 1195 1200 1205 gaa gaa att gag ttc agc gtt gag cgc tcc gca gtg gac aac cgc cca 3763 Glu Glu Ile Glu Phe Ser Val Glu Arg Ser Ala Val Asp Asn Arg Pro                 1210 1215 1220 gga atg gga gag gtc cgc acc gtt acc gca acc gtc aac ggc aac tta 3811 Gly Met Gly Glu Val Arg Thr Val Thr Ala Thr Val Asn Gly Asn Leu             1225 1230 1235 gtg ctt acc gcc acc gct gtt gtg gca gct cca tct act ttc tac gca 3859 Val Leu Thr Ala Thr Ala Val Val Ala Ala Pro Ser Thr Phe Tyr Ala         1240 1245 1250 ttc cca ggc cag ggc att cag tcc cag ggc atg ggt atg gaa gca cgc 3907 Phe Pro Gly Gln Gly Ile Gln Ser Gln Gly Met Gly Met Glu Ala Arg     1255 1260 1265 cgt aac tct cag gca gct cgc gct atc tgg gac cgc gcc gat gca cac 3955 Arg Asn Ser Gln Ala Ala Arg Ala Ile Trp Asp Arg Ala Asp Ala His 1270 1275 1280 1285 acc cgc aat aag ctg ggc ttc tcc atc gtg gaa atc gtg gaa aac aac 4003 Thr Arg Asn Lys Leu Gly Phe Ser Ile Val Glu Ile Val Glu Asn Asn                 1290 1295 1300 cca cgc gaa gta acc gtg gca ggg gag aag ttc ttc cac cca gac ggc 4051 Pro Arg Glu Val Thr Val Ala Gly Glu Lys Phe Phe His Pro Asp Gly             1305 1310 1315 gtt ttg tac ctc acc cag ttc acc cag gtg ggc atg gca act ctg ggc 4099 Val Leu Tyr Leu Thr Gln Phe Thr Gln Val Gly Met Ala Thr Leu Gly         1320 1325 1330 gtt gct cag atc gct gaa atg cgt gaa gca cat gcc ttg aac cag cgt 4147 Val Ala Gln Ile Ala Glu Met Arg Glu Ala His Ala Leu Asn Gln Arg     1335 1340 1345 gca tac ttt gct gga cac tcc gtt ggt gag tac aac gcg ctt gct gca 4195 Ala Tyr Phe Ala Gly His Ser Val Gly Glu Tyr Asn Ala Leu Ala Ala 1350 1355 1360 1365 tat gct ggt gtg ctg tcc ctg gaa tcc gtt ctg gag atc gtt tac cgt 4243 Tyr Ala Gly Val Leu Ser Leu Glu Ser Val Leu Glu Ile Val Tyr Arg                 1370 1375 1380 cgt ggc ttg acc atg cac cgc ttg gtg gat cgc gat gaa aac ggt ctg 4291 Arg Gly Leu Thr Met His Arg Leu Val Asp Arg Asp Glu Asn Gly Leu             1385 1390 1395 tcc aac tac gcg ctc gca gct ctt cgc ccc aac aag atg ggt ctg acc 4339 Ser Asn Tyr Ala Leu Ala Ala Leu Arg Pro Asn Lys Met Gly Leu Thr         1400 1405 1410 gca gac aac gtt ttc gat tac gtt gcg tct gtt tcc gaa gct tcc ggt 4387 Ala Asp Asn Val Phe Asp Tyr Val Ala Ser Val Ser Glu Ala Ser Gly     1415 1420 1425 gaa ttc ctg gag atc gtt aac tac aac ttg gct ggc ctg cag tac gca 4435 Glu Phe Leu Glu Ile Val Asn Tyr Asn Leu Ala Gly Leu Gln Tyr Ala 1430 1435 1440 1445 gtt gct gga acc cag gct ggt ctt gcc gcc ctt cgt gcc gat gtt gag 4483 Val Ala Gly Thr Gln Ala Gly Leu Ala Ala Leu Arg Ala Asp Val Glu                 1450 1455 1460 aac cgt gca cca ggt cag cgt gcc ttc att ttg atc cct ggc att gac 4531 Asn Arg Ala Pro Gly Gln Arg Ala Phe Ile Leu Ile Pro Gly Ile Asp             1465 1470 1475 gtg cca ttc cac tcc tcc aag ctg cgc gac ggt gtg ggc gcg ttc cgt 4579 Val Pro Phe His Ser Ser Lys Leu Arg Asp Gly Val Gly Ala Phe Arg         1480 1485 1490 gag cac ctt gat tcc ctg atc cca gct gag ctg gat ctg gat gtg ctg 4627 Glu His Leu Asp Ser Leu Ile Pro Ala Glu Leu Asp Leu Asp Val Leu     1495 1500 1505 gtt ggc cgc tac att cca aac ttg gtg gct cgc cca ttc gaa ctc act 4675 Val Gly Arg Tyr Ile Pro Asn Leu Val Ala Arg Pro Phe Glu Leu Thr 1510 1515 1520 1525 gaa gag ttc gtg gca tcc atg gca gaa gtg gtg gag tcc acc tat gtc 4723 Glu Glu Phe Val Ala Ser Met Ala Glu Val Val Glu Ser Thr Tyr Val                 1530 1535 1540 aat gag atc ttg gct gat ttc aag gct gct tcc gcc gat aag cag aag 4771 Asn Glu Ile Leu Ala Asp Phe Lys Ala Ala Ser Ala Asp Lys Gln Lys             1545 1550 1555 ctt gcc cgc acg ttg ctt att gag ctg ctt gca tgg cag ttc gca tca 4819 Leu Ala Arg Thr Leu Leu Ile Glu Leu Leu Ala Trp Gln Phe Ala Ser         1560 1565 1570 cct gtg cgc tgg atc gag act cag gat ctg ttg atc aag ggc ctt caa 4867 Pro Val Arg Trp Ile Glu Thr Gln Asp Leu Leu Ile Lys Gly Leu Gln     1575 1580 1585 gct gag cgt ttc gtg gag gtc ggt gtt ggc tct gct cca acg ctt gcc 4915 Ala Glu Arg Phe Val Glu Val Gly Val Gly Ser Ala Pro Thr Leu Ala 1590 1595 1600 1605 aac atg atg ggc cag acc ctg cgc ctt cct cag tac gcg gac gcc acc 4963 Asn Met Met Gly Gln Thr Leu Arg Leu Pro Gln Tyr Ala Asp Ala Thr                 1610 1615 1620 att gag gtg tta aac att gag cgc gat cgc cca gtt gtg ttc gct acc 5011 Ile Glu Val Leu Asn Ile Glu Arg Asp Arg Pro Val Val Phe Ala Thr             1625 1630 1635 gat gag gtt gtg cgt gaa gtg gcg gtt gaa gag acc cca gca gct cct 5059 Asp Glu Val Val Arg Glu Val Ala Val Glu Glu Thr Pro Ala Ala Pro         1640 1645 1650 gca gaa acc act gaa acc cca gca acc cca gca acc cca gcc cct gtt 5107 Ala Glu Thr Thr Glu Thr Pro Ala Thr Pro Ala Thr Pro Ala Pro Val     1655 1660 1665 gca gct gca gcc cct gcc acc ggc ggc cct cgc cca gat gac atc agc 5155 Ala Ala Ala Ala Pro Ala Thr Gly Gly Pro Arg Pro Asp Asp Ile Ser 1670 1675 1680 1685 ttc act cct tct gat gcc act gaa atg ctc atc gct atc tgg acc aag 5203 Phe Thr Pro Ser Asp Ala Thr Glu Met Leu Ile Ala Ile Trp Thr Lys                 1690 1695 1700 gtt cgc cca gat cag atg ggt gcc act gat tcc atc gag acc ctg gtt 5251 Val Arg Pro Asp Gln Met Gly Ala Thr Asp Ser Ile Glu Thr Leu Val             1705 1710 1715 gag ggc gtg tcc tct cgc cgt aac cag ctc ctg ctg gat ctt ggt gtg 5299 Glu Gly Val Ser Ser Arg Arg Asn Gln Leu Leu Leu Asp Leu Gly Val         1720 1725 1730 gag ttc ggc ctc ggc gca att gac gga gca gcc gat gct gag ctc ggt 5347 Glu Phe Gly Leu Gly Ala Ile Asp Gly Ala Ala Asp Ala Glu Leu Gly     1735 1740 1745 gat cta aag gtc acc gtg tcc aag atg gct aag ggc tac aag gcg ttt 5395 Asp Leu Lys Val Thr Val Ser Lys Met Ala Lys Gly Tyr Lys Ala Phe 1750 1755 1760 1765 ggc cct gtg ctc tcc gat gct gca gct gat gcc ctg cgt cgc ctc act 5443 Gly Pro Val Leu Ser Asp Ala Ala Ala Asp Ala Leu Arg Arg Leu Thr                 1770 1775 1780 ggt cct acc ggt aag cgc ccg gga tac atc gca gag cgc gtc acc ggc 5491 Gly Pro Thr Gly Lys Arg Pro Gly Tyr Ile Ala Glu Arg Val Thr Gly             1785 1790 1795 acg tgg gaa ttg ggc cag ggc tgg gct gac cac gtg gtc gct gaa gtt 5539 Thr Trp Glu Leu Gly Gln Gly Trp Ala Asp His Val Val Ala Glu Val         1800 1805 1810 gtg atc ggc gcc cgc gaa ggc gca tcc ctg cgc ggc ggc gac ctg gcg 5587 Val Ile Gly Ala Arg Glu Gly Ala Ser Leu Arg Gly Gly Asp Leu Ala     1815 1820 1825 tca ctg tct cct gca agc cca gcg tct gca tca gat ctt gat tcg ctt 5635 Ser Leu Ser Pro Ala Ser Pro Ala Ser Ala Ser Asp Leu Asp Ser Leu 1830 1835 1840 1845 atc gac gca gcc gtc cag gcc gta gcc tcc cgc cgc ggc gtt gcg gtc 5683 Ile Asp Ala Ala Val Gln Ala Val Ala Ser Arg Arg Gly Val Ala Val                 1850 1855 1860 tcc ctg cct tca gca ggc ggc gct gcc ggt ggc gtg gtt gat tcc gca 5731 Ser Leu Pro Ser Ala Gly Gly Ala Ala Gly Gly Val Val Asp Ser Ala             1865 1870 1875 gct ctt ggc gag ttt gca gag cag gtc acc gga cac gat ggt gtg ctt 5779 Ala Leu Gly Glu Phe Ala Glu Gln Val Thr Gly His Asp Gly Val Leu         1880 1885 1890 gct cag gca gcc cgc acc atc ttg acc cag ttg ggt ctt gat aag cca 5827 Ala Gln Ala Ala Arg Thr Ile Leu Thr Gln Leu Gly Leu Asp Lys Pro     1895 1900 1905 gca acc gtt tcc gtg gaa gac acc gca gag gaa gac ctc tac gag ttg 5875 Ala Thr Val Ser Val Glu Asp Thr Ala Glu Glu Asp Leu Tyr Glu Leu 1910 1915 1920 1925 gtc tcc aag gaa ctc ggt tct gat tgg cca cgt cag gtt gca cca agc 5923 Val Ser Lys Glu Leu Gly Ser Asp Trp Pro Arg Gln Val Ala Pro Ser                 1930 1935 1940 ttc gat gaa gaa aag gtt gtt ctg ctt gat gac cgt tgg gct tct gcg 5971 Phe Asp Glu Glu Lys Val Val Leu Leu Asp Asp Arg Trp Ala Ser Ala             1945 1950 1955 cgt gag gat ctc tcc gcg ttg ctc ttg gcg aac tcg cag caa ctg ata 6019 Arg Glu Asp Leu Ser Ala Leu Leu Leu Ala Asn Ser Gln Gln Leu Ile         1960 1965 1970 tcg atg tca cag gcg cag gcg aag ctg ttg cag cac aag ctg aat tct 6067 Ser Met Ser Gln Ala Gln Ala Lys Leu Leu Gln His Lys Leu Asn Ser     1975 1980 1985 ttg gac ttg atg atc tcg cag cta ggc tcg cga aca aag ctt ctt gga 6115 Leu Asp Leu Met Ile Ser Gln Leu Gly Ser Arg Thr Lys Leu Leu Gly 1990 1995 2000 2005 cta cgc cga caa tgt tgc ggc 6136 Leu Arg Arg Gln Cys Cys Gly                 2010 <210> 50 <211> 2012 <212> PRT <213> Corynebacterium glutamicum <400> 50 Leu Lys Thr Leu Arg Ala Ala Val Ala Ala Gly Ala Gly Thr Asn Val   1 5 10 15 Ser Asp Ile Val Glu Arg Ala Asn Ala Leu Leu Ala Leu Val Ala Asp              20 25 30 Asp Leu Ile Gly Thr Leu Pro Phe Gly Phe Asp Pro Val Ala Trp Ala          35 40 45 Asn Asn Ser Glu Asp Pro Ala Phe Asp Thr Ala Gln Ser Ala Val Ser      50 55 60 Val Pro Gly Ile Phe Val Ser Gln Ile Ala Thr Leu Asp Ser Leu Glu  65 70 75 80 Ala Gln Arg Leu Asp Val Asp Gln Ala Val Ser Ser Ile Gly His Ser                  85 90 95 Gln Gly Val Leu Gly Val His Leu Leu Asn Asp Ala Thr Arg Ala Asp             100 105 110 Glu Leu Val Ala Ile Ala Gln Leu Ile Gly Ala Ala Ile Thr Arg Thr         115 120 125 Ala Arg Met Thr Gly Leu Ile Ala Gln Gly Asp Asn Met Pro Met Leu     130 135 140 Ser Ile Ala Gly Ile Ser Arg Glu Gln Leu Gln Gln Ala Ile Asp Ala 145 150 155 160 Ala Cys Ala Glu Val Pro Ala Glu Ile Arg Pro Val Ile Gly Leu Arg                 165 170 175 Asn Ser Arg Asp Ser Tyr Val Leu Val Gly Arg Pro Asp Asp Asn Ala             180 185 190 Arg Val Val Lys Val Ile Glu Ala Met Ala Ala Lys Asp Lys Lys Ala         195 200 205 Ile Glu Asp Lys Leu Arg Gly Gly Ser Ala Phe Ser Pro Arg Ile Thr     210 215 220 Pro Leu Lys Val Gln Ala Ala Phe His His Pro Ala Met Asn Met Ala 225 230 235 240 Val Glu Gln Thr Val Ala Trp Ala Thr Thr Ala Gly Leu Asp Val Glu                 245 250 255 Leu Thr Arg Glu Ile Ala Ala Asp Val Leu Val Asn Pro Val Asp Trp             260 265 270 Val Ala Arg Val Asn Glu Ala Tyr Glu Ala Gly Ala Arg Trp Phe Leu         275 280 285 Asp Val Gly Pro Asp Gly Gly Ile Val Lys Leu Thr Ala Asn Ile Leu     290 295 300 Glu Gly Arg Gly Ala Asp Ser Phe Tyr Val Gly Asp Ala Ala Gly Gln 305 310 315 320 Ala Lys Ile Phe Asp Ala Gly Met Ala Pro Glu Leu Pro Val Asp Tyr                 325 330 335 Gln Glu Phe Ala Pro Arg Val Glu His Val Asp Gly Thr Pro Arg Leu             340 345 350 Val Thr Lys Phe Thr Glu Leu Thr Gly Arg Thr Pro Met Met Leu Ala         355 360 365 Gly Met Thr Pro Thr Thr Val Asp Pro Ala Ile Val Ala Ala Ala Ala     370 375 380 Asn Gly Gly His Trp Ala Glu Leu Ala Gly Gly Gly Gln Val Thr Pro 385 390 395 400 Glu Leu Leu Glu Thr His Ile Ala Gln Leu Thr Asp Met Leu Glu Pro                 405 410 415 Gly Ile Asn Ala Gln Phe Asn Ser Met Phe Leu Asp Pro Tyr Leu Trp             420 425 430 Lys Met Gln Ile Gly Gly Lys Arg Leu Val Pro Lys Ala Arg Ala Asn         435 440 445 Gly Ala Ser Ile Asp Gly Ile Val Ile Thr Ala Gly Ile Pro Glu Lys     450 455 460 Asp Glu Ala Val Ala Leu Val Lys Glu Leu Met Arg Asp Gly Phe Pro 465 470 475 480 Trp Ile Ala Phe Lys Pro Gly Ala Ile Lys Gln Val Asn Ser Val Leu                 485 490 495 Ala Ile Ala Lys Glu Val Pro Glu Leu Pro Ile Ile Ile Gln Ile Glu             500 505 510 Gly Gly Val Ala Gly Gly His His Ser Trp Glu Asp Leu Asp Glu Leu         515 520 525 Leu Ile Ala Thr Tyr Gly Lys Val Arg Ala Leu Asp Asn Val Val Leu     530 535 540 Cys Val Gly Gly Gly Ile Gly Ser Pro Glu Arg Ala Ala Asp Tyr Val 545 550 555 560 Thr Gly Ser Trp Ser Thr Ser Tyr Gly Leu Pro Ala Met Pro Val Asp                 565 570 575 Gly Ile Leu Val Gly Thr Ala Ala Met Ala Thr Lys Glu Ala Thr Thr             580 585 590 Ser Gln Ala Val Lys Glu Leu Leu Val Ser Thr Gln Gly Ser Asp Glu         595 600 605 Trp Val Pro Ala Gly Gly Ala Lys Asn Gly Met Ala Ser Gly Arg Ser     610 615 620 Gln Leu Gly Ala Asp Ile His Glu Ile Asp Asn Ser Phe Ala Lys Ala 625 630 635 640 Gly Arg Leu Leu Asp Glu Val Ala Gly Asp Glu Thr Ala Val Gln Ala                 645 650 655 Arg Arg Asp Glu Ile Ile Glu Ala Ile Gly Lys Thr Ala Lys Val Tyr             660 665 670 Phe Gly Asp Ile Gly Ser Met Thr Tyr Glu Gln Trp Leu Asn Arg Tyr         675 680 685 Leu Glu Leu Ser Gly Pro Val Asp Gly Gln Trp Ile Asp Ala Ser Trp     690 695 700 Ala Ala Arg Phe Ala Gln Met Leu Glu Arg Ala Glu Ala Arg Leu Ile 705 710 715 720 Glu Gln Asp His Gly Gln Phe Glu Pro Ser Leu Thr Val Glu Asp Gly                 725 730 735 Val Asp Lys Leu Val Ala Ala Tyr Pro His Ala Ala Thr Asp Leu Leu             740 745 750 Thr Pro Ala Asp Val Ala Trp Phe Leu Gly Leu Cys Arg Thr Pro Gly         755 760 765 Lys Pro Val Asn Phe Val Pro Val Ile Asp Lys Asp Val Arg Arg Trp     770 775 780 Trp Arg Ser Asp Ser Leu Trp Gln Ser His Asp Asp Arg Tyr Thr Ala 785 790 795 800 Asp Gln Val Ala Ile Ile Pro Gly Val Val Ala Val Ala Gly Ile Thr                 805 810 815 Lys Ala Asn Glu Pro Val Ala Asp Leu Leu Asp Arg Phe Val Asp Ala             820 825 830 Thr Ile Glu Arg Ile Asp Glu His Asp Ser Arg Ser Arg Asp Ile Met         835 840 845 Gly Lys Val Leu Ser Ser Pro Gly Thr Phe Trp Ala Gly Arg Asn Ile     850 855 860 Pro Ser Val Ile His Ser Leu Gly His Ala Asp Lys Trp Ser Arg Ser 865 870 875 880 Glu Phe Glu Ala Phe His Ser Pro Thr Gly Ala Asn Leu Val Tyr Glu                 885 890 895 Asp Ala Glu His Ala Met Leu Thr Val Pro Leu Ala Gly Ser Thr Ala             900 905 910 Phe Gly Thr Thr Ala Glu Leu Lys Ile Arg Phe Thr Ser Pro Ile Asp         915 920 925 Ala Leu Pro Ser Ala Val Pro Leu Val Thr Gln Glu Asp Ala Glu Ala     930 935 940 Ala Met Gly Glu Leu Thr Arg Ile Ala Ala Gly Gly Thr Leu Ala Thr 945 950 955 960 Val Asn Asn Gly Thr Ala Thr Trp Glu Thr Ser Val Asp Ala Gly Val                 965 970 975 Ile Ala Asp Tyr Asn Asn Val Thr Ala Gly Tyr Leu Pro Ala Ser Val             980 985 990 Val Pro Ala His Thr Ala Pro Asp Val Leu Val Gly Arg Ala Trp Pro         995 1000 1005 Ala Val Phe Ala Ala Val Lys Ser Ala Val Ile Pro Gly Thr Asp Ser     1010 1015 1020 Ala Ser Val Val Glu Gly Met Leu Ser Leu Val His Leu Glu His His 1025 1030 1035 1040 Ile Val Leu Lys Ser Asp Val Pro Thr Asp Gly Ala Leu Lys Val Ser                 1045 1050 1055 Ala Thr Ala Asp Glu Val Val Asp Thr Asp Leu Gly Arg Leu Val Ile             1060 1065 1070 Val Arg Ala Glu Ile Ala Asp Ala Glu Gly Asn Leu Ile Ala Thr Leu         1075 1080 1085 Ala Glu Arg Phe Ala Ile Arg Gly Arg Lys Gly Asn Ala Val Ala Arg     1090 1095 1100 Thr Asn Thr Ser Ala Leu Pro Thr Thr Val Asp Thr Pro Arg Ser Ala 1105 1110 1115 1120 Arg Ala Val Ala Thr Val Val Ala Pro Glu Ser Met Arg Pro Phe Ala                 1125 1130 1135 Val Ile Ser Gly Asp Arg Asn Pro Ile His Val Ser Asp Val Ala Ala             1140 1145 1150 Ser Leu Ala Gly Leu Pro Gly Val Ile Val His Gly Met Trp Thr Ser         1155 1160 1165 Ala Ile Gly Glu Leu Ile Ala Gly Ala Ala Phe Asn Asp Glu Gln Ile     1170 1175 1180 Gln Thr Pro Ala Ala Lys Val Val Glu Tyr Thr Ala Thr Met Leu Ala 1185 1190 1195 1200 Pro Val Leu Pro Gly Glu Glu Ile Glu Phe Ser Val Glu Arg Ser Ala                 1205 1210 1215 Val Asp Asn Arg Pro Gly Met Gly Glu Val Arg Thr Val Thr Ala Thr             1220 1225 1230 Val Asn Gly Asn Leu Val Leu Thr Ala Thr Ala Val Val Ala Ala Pro         1235 1240 1245 Ser Thr Phe Tyr Ala Phe Pro Gly Gln Gly Ile Gln Ser Gln Gly Met     1250 1255 1260 Gly Met Glu Ala Arg Arg Asn Ser Gln Ala Ala Arg Ala Ile Trp Asp 1265 1270 1275 1280 Arg Ala Asp Ala His Thr Arg Asn Lys Leu Gly Phe Ser Ile Val Glu                 1285 1290 1295 Ile Val Glu Asn Asn Pro Arg Glu Val Thr Val Ala Gly Glu Lys Phe             1300 1305 1310 Phe His Pro Asp Gly Val Leu Tyr Leu Thr Gln Phe Thr Gln Val Gly         1315 1320 1325 Met Ala Thr Leu Gly Val Ala Gln Ile Ala Glu Met Arg Glu Ala His     1330 1335 1340 Ala Leu Asn Gln Arg Ala Tyr Phe Ala Gly His Ser Val Gly Glu Tyr 1345 1350 1355 1360 Asn Ala Leu Ala Ala Tyr Ala Gly Val Leu Ser Leu Glu Ser Val Leu                 1365 1370 1375 Glu Ile Val Tyr Arg Arg Gly Leu Thr Met His Arg Leu Val Asp Arg             1380 1385 1390 Asp Glu Asn Gly Leu Ser Asn Tyr Ala Leu Ala Ala Leu Arg Pro Asn         1395 1400 1405 Lys Met Gly Leu Thr Ala Asp Asn Val Phe Asp Tyr Val Ala Ser Val     1410 1415 1420 Ser Glu Ala Ser Gly Glu Phe Leu Glu Ile Val Asn Tyr Asn Leu Ala 1425 1430 1435 1440 Gly Leu Gln Tyr Ala Val Ala Gly Thr Gln Ala Gly Leu Ala Ala Leu                 1445 1450 1455 Arg Ala Asp Val Glu Asn Arg Ala Pro Gly Gln Arg Ala Phe Ile Leu             1460 1465 1470 Ile Pro Gly Ile Asp Val Pro Phe His Ser Ser Lys Leu Arg Asp Gly         1475 1480 1485 Val Gly Ala Phe Arg Glu His Leu Asp Ser Leu Ile Pro Ala Glu Leu     1490 1495 1500 Asp Leu Asp Val Leu Val Gly Arg Tyr Ile Pro Asn Leu Val Ala Arg 1505 1510 1515 1520 Pro Phe Glu Leu Thr Glu Glu Phe Val Ala Ser Met Ala Glu Val Val                 1525 1530 1535 Glu Ser Thr Tyr Val Asn Glu Ile Leu Ala Asp Phe Lys Ala Ala Ser             1540 1545 1550 Ala Asp Lys Gln Lys Leu Ala Arg Thr Leu Leu Ile Glu Leu Leu Ala         1555 1560 1565 Trp Gln Phe Ala Ser Pro Val Arg Trp Ile Glu Thr Gln Asp Leu Leu     1570 1575 1580 Ile Lys Gly Leu Gln Ala Glu Arg Phe Val Glu Val Gly Val Gly Ser 1585 1590 1595 1600 Ala Pro Thr Leu Ala Asn Met Met Gly Gln Thr Leu Arg Leu Pro Gln                 1605 1610 1615 Tyr Ala Asp Ala Thr Ile Glu Val Leu Asn Ile Glu Arg Asp Arg Pro             1620 1625 1630 Val Val Phe Ala Thr Asp Glu Val Val Arg Glu Val Ala Val Glu Glu         1635 1640 1645 Thr Pro Ala Ala Pro Ala Glu Thr Thr Glu Thr Pro Ala Thr Pro Ala     1650 1655 1660 Thr Pro Ala Pro Val Ala Ala Ala Ala Pro Ala Thr Gly Gly Pro Arg 1665 1670 1675 1680 Pro Asp Asp Ile Ser Phe Thr Pro Ser Asp Ala Thr Glu Met Leu Ile                 1685 1690 1695 Ala Ile Trp Thr Lys Val Arg Pro Asp Gln Met Gly Ala Thr Asp Ser             1700 1705 1710 Ile Glu Thr Leu Val Glu Gly Val Ser Ser Arg Arg Asn Gln Leu Leu         1715 1720 1725 Leu Asp Leu Gly Val Glu Phe Gly Leu Gly Ala Ile Asp Gly Ala Ala     1730 1735 1740 Asp Ala Glu Leu Gly Asp Leu Lys Val Thr Val Ser Lys Met Ala Lys 1745 1750 1755 1760 Gly Tyr Lys Ala Phe Gly Pro Val Leu Ser Asp Ala Ala Asp Ala                 1765 1770 1775 Leu Arg Arg Leu Thr Gly Pro Thr Gly Lys Arg Pro Gly Tyr Ile Ala             1780 1785 1790 Glu Arg Val Thr Gly Thr Trp Glu Leu Gly Gln Gly Trp Ala Asp His         1795 1800 1805 Val Val Ala Glu Val Val Ile Gly Ala Arg Glu Gly Ala Ser Leu Arg     1810 1815 1820 Gly Gly Asp Leu Ala Ser Leu Ser Pro Ala Ser Pro Ala Ser Ala Ser 1825 1830 1835 1840 Asp Leu Asp Ser Leu Ile Asp Ala Ala Val Gln Ala Val Ala Ser Arg                 1845 1850 1855 Arg Gly Val Ala Val Ser Leu Pro Ser Ala Gly Gly Ala Ala Gly Gly             1860 1865 1870 Val Val Asp Ser Ala Ala Leu Gly Glu Phe Ala Glu Gln Val Thr Gly         1875 1880 1885 His Asp Gly Val Leu Ala Gln Ala Ala Arg Thr Ile Leu Thr Gln Leu     1890 1895 1900 Gly Leu Asp Lys Pro Ala Thr Val Ser Val Glu Asp Thr Ala Glu Glu 1905 1910 1915 1920 Asp Leu Tyr Glu Leu Val Ser Lys Glu Leu Gly Ser Asp Trp Pro Arg                 1925 1930 1935 Gln Val Ala Pro Ser Phe Asp Glu Glu Lys Val Val Leu Leu Asp Asp             1940 1945 1950 Arg Trp Ala Ser Ala Arg Glu Asp Leu Ser Ala Leu Leu Leu Ala Asn         1955 1960 1965 Ser Gln Gln Leu Ile Ser Met Ser Gln Ala Gln Ala Lys Leu Leu Gln     1970 1975 1980 His Lys Leu Asn Ser Leu Asp Leu Met Ile Ser Gln Leu Gly Ser Arg 1985 1990 1995 2000 Thr Lys Leu Leu Gly Leu Arg Arg Gln Cys Cys Gly                 2005 2010 <210> 51 <211> 2185 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (2185) <223> FRXA00158 <400> 51 cgtgccattt tctttacaaa agagtattaa ccgaaacttc aggtcaggat ccacgccctg 60 cgttcatccc ggctaagtta tacaaggagc gagttctcac gtg acc gaa ttg agc 115                                             Val Thr Glu Leu Ser                                               1 5 agg aac ttc ggg gcc agc cga ctg att aac cgc ttt ggc cag gag cct 163 Arg Asn Phe Gly Ala Ser Arg Leu Ile Asn Arg Phe Gly Gln Glu Pro                  10 15 20 ttt gcc ttc gct ttc gcc ggc caa gga tat gac tgg ttg aag acc ctt 211 Phe Ala Phe Ala Phe Ala Gly Gln Gly Tyr Asp Trp Leu Lys Thr Leu              25 30 35 cgt gcc gcg gtt gcc gca ggt gca ggc acc aat gtt agt gac atc gtc 259 Arg Ala Ala Val Ala Ala Gly Ala Gly Thr Asn Val Ser Asp Ile Val          40 45 50 gag cgc gca aat gcg ctg ctt gca cta gtt gca gat gat ctc att ggc 307 Glu Arg Ala Asn Ala Leu Leu Ala Leu Val Ala Asp Asp Leu Ile Gly      55 60 65 acc ctt cca ttt ggt ttc gat cca gtg gct tgg gct aac aac tcc gaa 355 Thr Leu Pro Phe Gly Phe Asp Pro Val Ala Trp Ala Asn Asn Ser Glu  70 75 80 85 gat cca gct ttc gat act gca caa tct gca gtg agc gtg ccg ggt atc 403 Asp Pro Ala Phe Asp Thr Ala Gln Ser Ala Val Ser Val Pro Gly Ile                  90 95 100 ttt gtc tcc cag atc gca acc ctg gat tcc ctt gag gcg cag cgc ctt 451 Phe Val Ser Gln Ile Ala Thr Leu Asp Ser Leu Glu Ala Gln Arg Leu             105 110 115 gat gtg gat cag gct gtg tcc agc att ggt cat tcc cag ggc gta ttg 499 Asp Val Asp Gln Ala Val Ser Ser Ile Gly His Ser Gln Gly Val Leu         120 125 130 ggc gtg cac ctg ctc aat gat gcg act cgt gct gat gaa ctc gtt gcc 547 Gly Val His Leu Leu Asn Asp Ala Thr Arg Ala Asp Glu Leu Val Ala     135 140 145 att gcg cag ttg atc ggt gca gcg atc acc cgc acc gca cgc atg acg 595 Ile Ala Gln Leu Ile Gly Ala Ala Ile Thr Arg Thr Ala Arg Met Thr 150 155 160 165 ggc ctg atc gcg cag ggc gac aac atg ccg atg ctg tcg atc gcc gga 643 Gly Leu Ile Ala Gln Gly Asp Asn Met Pro Met Leu Ser Ile Ala Gly                 170 175 180 att tcc cgc gaa cag ctt cag caa gct atc gac gcg gcc tgc gcc gaa 691 Ile Ser Arg Glu Gln Leu Gln Gln Ala Ile Asp Ala Ala Cys Ala Glu             185 190 195 gtc cct gcg gag atc cgc ccg gtt atc ggt ctg cgc aac tca cgc gat 739 Val Pro Ala Glu Ile Arg Pro Val Ile Gly Leu Arg Asn Ser Arg Asp         200 205 210 tct tat gtt ttg gtt ggc cgc cca gac gac aac gct cgc gtt gtt aag 787 Ser Tyr Val Leu Val Gly Arg Pro Asp Asp Asn Ala Arg Val Val Lys     215 220 225 gtc att gag gca atg gct gcc aag gat aag aag gcc att gaa gat aag 835 Val Ile Glu Ala Met Ala Ala Lys Asp Lys Lys Ala Ile Glu Asp Lys 230 235 240 245 ctg cgc ggc ggt tcc gcg ttc agc ccc cgt att act ccg ctg aag gtg 883 Leu Arg Gly Gly Ser Ala Phe Ser Pro Arg Ile Thr Pro Leu Lys Val                 250 255 260 cag gct gct ttc cat cac cca gct atg aac atg gct gtg gag cag acc 931 Gln Ala Ala Phe His His Pro Ala Met Asn Met Ala Val Glu Gln Thr             265 270 275 gtg gcg tgg gca acc act gct ggt ttg gat gtg gaa ctc acc cgc gag 979 Val Ala Trp Ala Thr Thr Ala Gly Leu Asp Val Glu Leu Thr Arg Glu         280 285 290 atc gcc gct gat gtt ttg gtt aac cct gtc gat tgg gta gca cgc gtc 1027 Ile Ala Ala Asp Val Leu Val Asn Pro Val Asp Trp Val Ala Arg Val     295 300 305 aac gaa gcg tat gag gct ggc gct cgc tgg ttc ctc gac gtt gga cca 1075 Asn Glu Ala Tyr Glu Ala Gly Ala Arg Trp Phe Leu Asp Val Gly Pro 310 315 320 325 gat ggt ggc atc gtt aag ctg act gcc aac atc ctt gag ggc cgc ggc 1123 Asp Gly Gly Ile Val Lys Leu Thr Ala Asn Ile Leu Glu Gly Arg Gly                 330 335 340 gcg gat tcc ttc tat gtt ggt gac gcc gca ggc cag gcc aag ata ttt 1171 Ala Asp Ser Phe Tyr Val Gly Asp Ala Ala Gly Gln Ala Lys Ile Phe             345 350 355 gat gct ggc atg gca cct gaa ctt cca gtg gat tac cag gag ttc gca 1219 Asp Ala Gly Met Ala Pro Glu Leu Pro Val Asp Tyr Gln Glu Phe Ala         360 365 370 cca cgc gtt gag cac gtt gat gga acc cca cgc ctg gtt acc aag ttc 1267 Pro Arg Val Glu His Val Asp Gly Thr Pro Arg Leu Val Thr Lys Phe     375 380 385 act gag ctg acc ggc cgc acc cca atg atg ctg gct ggc atg acc cca 1315 Thr Glu Leu Thr Gly Arg Thr Pro Met Met Leu Ala Gly Met Thr Pro 390 395 400 405 acc acc gtt gac cct gcc att gtt gca gcc gct gca aac ggt gga cac 1363 Thr Thr Val Asp Pro Ala Ile Val Ala Ala Ala Ala Asn Gly Gly His                 410 415 420 tgg gct gag ctc gct ggt ggc gga cag gtt acc cca gag ctg ctg gaa 1411 Trp Ala Glu Leu Ala Gly Gly Gly Gln Val Thr Pro Glu Leu Leu Glu             425 430 435 acc cac atc gca cag ctc acc gac atg ctt gag cca ggt atc aac gcc 1459 Thr His Ile Ala Gln Leu Thr Asp Met Leu Glu Pro Gly Ile Asn Ala         440 445 450 cag ttc aac tcc atg ttc ttg gat cca tac ctg tgg aag atg cag att 1507 Gln Phe Asn Ser Met Phe Leu Asp Pro Tyr Leu Trp Lys Met Gln Ile     455 460 465 ggt ggc aag cgc ctt gtt cct aag gcc cgc gct aat ggt gca tcc atc 1555 Gly Gly Lys Arg Leu Val Pro Lys Ala Arg Ala Asn Gly Ala Ser Ile 470 475 480 485 gac ggc atc gtc atc acc gcc ggc att cct gaa aag gat gaa gct gtt 1603 Asp Gly Ile Val Ile Thr Ala Gly Ile Pro Glu Lys Asp Glu Ala Val                 490 495 500 gca ttg gtc aag gaa ctg atg cgt gat ggt ttc cct tgg atc gca ttc 1651 Ala Leu Val Lys Glu Leu Met Arg Asp Gly Phe Pro Trp Ile Ala Phe             505 510 515 aag cca ggt gcc atc aag cag gtt aac tct gtg ttg gct atc gct aag 1699 Lys Pro Gly Ala Ile Lys Gln Val Asn Ser Val Leu Ala Ile Ala Lys         520 525 530 gaa gtt cca gaa ctc ccc atc atc att cag att gag ggt ggc gtt gca 1747 Glu Val Pro Glu Leu Pro Ile Ile Ile Gln Ile Glu Gly Gly Val Ala     535 540 545 ggt gga cac cac tct tgg gaa gac ctc gat gag ctg ctg atc gcc acc 1795 Gly Gly His His Ser Trp Glu Asp Leu Asp Glu Leu Leu Ile Ala Thr 550 555 560 565 tac ggc aag gtc cgc gca ctg gat aac gtg gtg ctg tgt gtc ggc ggt 1843 Tyr Gly Lys Val Arg Ala Leu Asp Asn Val Val Leu Cys Val Gly Gly                 570 575 580 ggc att ggc tca cct gag cgc gct gct gat tac gtc acc ggt tcc tgg 1891 Gly Ile Gly Ser Pro Glu Arg Ala Ala Asp Tyr Val Thr Gly Ser Trp             585 590 595 tcc act tcc tac ggc ctg cca gct atg cct gtt gat ggc atc ttg gtg 1939 Ser Thr Ser Tyr Gly Leu Pro Ala Met Pro Val Asp Gly Ile Leu Val         600 605 610 ggt acc gct gcg atg gca acc aag gaa gca acc acc tcc cag gcc gtc 1987 Gly Thr Ala Ala Met Ala Thr Lys Glu Ala Thr Thr Ser Gln Ala Val     615 620 625 aag gaa ctt ctt gtt tcc acc cag ggc tct gat gaa tgg gtt cct gct 2035 Lys Glu Leu Leu Val Ser Thr Gln Gly Ser Asp Glu Trp Val Pro Ala 630 635 640 645 ggt ggc gca aag aac gga atg gca tat ggc cgt tcc cag ctt ggc gca 2083 Gly Gly Ala Lys Asn Gly Met Ala Tyr Gly Arg Ser Gln Leu Gly Ala                 650 655 660 gac atc cac gag atc gac aac tcc ttt gct aag gct gga cgc ctt ctt 2131 Asp Ile His Glu Ile Asp Asn Ser Phe Ala Lys Ala Gly Arg Leu Leu             665 670 675 gat gag gtt gca ggc cat gaa acg gat ttg caa gcg cgc ccg gat gag 2179 Asp Glu Val Ala Gly His Glu Thr Asp Leu Gln Ala Arg Pro Asp Glu         680 685 690 atc att 2185 Ile Ile     695 <210> 52 <211> 695 <212> PRT <213> Corynebacterium glutamicum <400> 52 Val Thr Glu Leu Ser Arg Asn Phe Gly Ala Ser Arg Leu Ile Asn Arg   1 5 10 15 Phe Gly Gln Glu Pro Phe Ala Phe Ala Phe Ala Gly Gln Gly Tyr Asp              20 25 30 Trp Leu Lys Thr Leu Arg Ala Ala Val Ala Ala Gly Ala Gly Thr Asn          35 40 45 Val Ser Asp Ile Val Glu Arg Ala Asn Ala Leu Leu Ala Leu Val Ala      50 55 60 Asp Asp Leu Ile Gly Thr Leu Pro Phe Gly Phe Asp Pro Val Ala Trp  65 70 75 80 Ala Asn Asn Ser Glu Asp Pro Ala Phe Asp Thr Ala Gln Ser Ala Val                  85 90 95 Ser Val Pro Gly Ile Phe Val Ser Gln Ile Ala Thr Leu Asp Ser Leu             100 105 110 Glu Ala Gln Arg Leu Asp Val Asp Gln Ala Val Ser Ser Ile Gly His         115 120 125 Ser Gln Gly Val Leu Gly Val His Leu Leu Asn Asp Ala Thr Arg Ala     130 135 140 Asp Glu Leu Val Ala Ile Ala Gln Leu Ile Gly Ala Ala Ile Thr Arg 145 150 155 160 Thr Ala Arg Met Thr Gly Leu Ile Ala Gln Gly Asp Asn Met Pro Met                 165 170 175 Leu Ser Ile Ala Gly Ile Ser Arg Glu Gln Leu Gln Gln Ala Ile Asp             180 185 190 Ala Ala Cys Ala Glu Val Pro Ala Glu Ile Arg Pro Val Ile Gly Leu         195 200 205 Arg Asn Ser Arg Asp Ser Tyr Val Leu Val Gly Arg Pro Asp Asp Asn     210 215 220 Ala Arg Val Val Lys Val Ile Glu Ala Met Ala Ala Lys Asp Lys Lys 225 230 235 240 Ala Ile Glu Asp Lys Leu Arg Gly Gly Ser Ala Phe Ser Pro Arg Ile                 245 250 255 Thr Pro Leu Lys Val Gln Ala Ala Phe His His Pro Ala Met Asn Met             260 265 270 Ala Val Glu Gln Thr Val Ala Trp Ala Thr Thr Ala Gly Leu Asp Val         275 280 285 Glu Leu Thr Arg Glu Ile Ala Ala Asp Val Leu Val Asn Pro Val Asp     290 295 300 Trp Val Ala Arg Val Asn Glu Ala Tyr Glu Ala Gly Ala Arg Trp Phe 305 310 315 320 Leu Asp Val Gly Pro Asp Gly Gly Ile Val Lys Leu Thr Ala Asn Ile                 325 330 335 Leu Glu Gly Arg Gly Ala Asp Ser Phe Tyr Val Gly Asp Ala Ala Gly             340 345 350 Gln Ala Lys Ile Phe Asp Ala Gly Met Ala Pro Glu Leu Pro Val Asp         355 360 365 Tyr Gln Glu Phe Ala Pro Arg Val Glu His Val Asp Gly Thr Pro Arg     370 375 380 Leu Val Thr Lys Phe Thr Glu Leu Thr Gly Arg Thr Pro Met Met Leu 385 390 395 400 Ala Gly Met Thr Pro Thr Thr Val Asp Pro Ala Ile Val Ala Ala Ala                 405 410 415 Ala Asn Gly Gly His Trp Ala Glu Leu Ala Gly Gly Gly Gln Val Thr             420 425 430 Pro Glu Leu Leu Glu Thr His Ile Ala Gln Leu Thr Asp Met Leu Glu         435 440 445 Pro Gly Ile Asn Ala Gln Phe Asn Ser Met Phe Leu Asp Pro Tyr Leu     450 455 460 Trp Lys Met Gln Ile Gly Lys Arg Leu Val Pro Lys Ala Arg Ala 465 470 475 480 Asn Gly Ala Ser Ile Asp Gly Ile Val Ile Thr Ala Gly Ile Pro Glu                 485 490 495 Lys Asp Glu Ala Val Ala Leu Val Lys Glu Leu Met Arg Asp Gly Phe             500 505 510 Pro Trp Ile Ala Phe Lys Pro Gly Ala Ile Lys Gln Val Asn Ser Val         515 520 525 Leu Ala Ile Ala Lys Glu Val Pro Glu Leu Pro Ile Ile Ile Gln Ile     530 535 540 Glu Gly Gly Val Ala Gly Gly His His Ser Trp Glu Asp Leu Asp Glu 545 550 555 560 Leu Leu Ile Ala Thr Tyr Gly Lys Val Arg Ala Leu Asp Asn Val Val                 565 570 575 Leu Cys Val Gly Gly Gly Ile Gly Ser Pro Glu Arg Ala Ala Asp Tyr             580 585 590 Val Thr Gly Ser Trp Ser Thr Ser Tyr Gly Leu Pro Ala Met Pro Val         595 600 605 Asp Gly Ile Leu Val Gly Thr Ala Ala Met Ala Thr Lys Glu Ala Thr     610 615 620 Thr Ser Gln Ala Val Lys Glu Leu Leu Val Ser Thr Gln Gly Ser Asp 625 630 635 640 Glu Trp Val Pro Ala Gly Gly Ala Lys Asn Gly Met Ala Tyr Gly Arg                 645 650 655 Ser Gln Leu Gly Ala Asp Ile His Glu Ile Asp Asn Ser Phe Ala Lys             660 665 670 Ala Gly Arg Leu Leu Asp Glu Val Ala Gly His Glu Thr Asp Leu Gln         675 680 685 Ala Arg Pro Asp Glu Ile Ile     690 695 <210> 53 <211> 3831 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) ... (3831) <223> FRXA00572 <400> 53 cag tgg ctc aac cgc tac ctc gag ctg tct ggc cct gtt gat ggt cag 48 Gln Trp Leu Asn Arg Tyr Leu Glu Leu Ser Gly Pro Val Asp Gly Gln   1 5 10 15 tgg att gat gct tcc tgg gct gca cgt ttt gcc cag atg ctg gag cgt 96 Trp Ile Asp Ala Ser Trp Ala Ala Arg Phe Ala Gln Met Leu Glu Arg              20 25 30 gcc gag gcg cgt ttg atc gag cag gat cat ggc caa ttt gag cca agc 144 Ala Glu Ala Arg Leu Ile Glu Gln Asp His Gly Gln Phe Glu Pro Ser          35 40 45 ctg acg gtg gag gat ggc gtc gac aag ctt gtt gct gct tac ccg cat 192 Leu Thr Val Glu Asp Gly Val Asp Lys Leu Val Ala Ala Tyr Pro His      50 55 60 gcc gca acc gac ctg ctc acc ccg gct gat gtc gcc tgg ttc ttg ggc 240 Ala Ala Thr Asp Leu Leu Thr Pro Ala Asp Val Ala Trp Phe Leu Gly  65 70 75 80 ctg tgc cgc acg ccg ggc aag cct gtg aac ttt gtg ccc gtc att gat 288 Leu Cys Arg Thr Pro Gly Lys Pro Val Asn Phe Val Pro Val Ile Asp                  85 90 95 aag gac gtg cgt cgc tgg tgg cgc tcg gac tcc ctg tgg cag tcc cac 336 Lys Asp Val Arg Arg Trp Trp Arg Ser Asp Ser Leu Trp Gln Ser His             100 105 110 gat gat cgc tac acc gct gat cag gtg gct att atc cct ggt gtc gtc 384 Asp Asp Arg Tyr Thr Ala Asp Gln Val Ala Ile Ile Pro Gly Val Val         115 120 125 gcc gtt gct ggc atc acc aag gcc aac gaa cct gtc gct gac ctg ctt 432 Ala Val Ala Gly Ile Thr Lys Ala Asn Glu Pro Val Ala Asp Leu Leu     130 135 140 gat cgc ttt gtc gac gcc acc atc gag cgc atc gat gag cac gat tcc 480 Asp Arg Phe Val Asp Ala Thr Ile Glu Arg Ile Asp Glu His Asp Ser 145 150 155 160 cgc tcc cgc gac atc atg ggc aaa gtg ctt tcc tca cct ggc aca ttc 528 Arg Ser Arg Asp Ile Met Gly Lys Val Leu Ser Ser Pro Gly Thr Phe                 165 170 175 tgg gct ggc cgc aac atc cca tcg gtg atc cac agc ctt ggg cat gct 576 Trp Ala Gly Arg Asn Ile Pro Ser Val Ile His Ser Leu Gly His Ala             180 185 190 gac aag tgg tcc cgc tcc gaa ttc gaa gca ttc cat agc cca acc ggc 624 Asp Lys Trp Ser Arg Ser Glu Phe Glu Ala Phe His Ser Pro Thr Gly         195 200 205 gcc aac ttg gtg tac gaa gac gcc gag cac gcg atg ctg act gtg cct 672 Ala Asn Leu Val Tyr Glu Asp Ala Glu His Ala Met Leu Thr Val Pro     210 215 220 ttg gcg ggt tcc acc gca ttc ggc acc acc gct gag ctg aaa atc cgt 720 Leu Ala Gly Ser Thr Ala Phe Gly Thr Thr Ala Glu Leu Lys Ile Arg 225 230 235 240 ttc acc agc ccc atc gac gct ctg cca agc gct gtc cca ctg gtc acc 768 Phe Thr Ser Pro Ile Asp Ala Leu Pro Ser Ala Val Pro Leu Val Thr                 245 250 255 cag gaa gac gct gaa gcc gcg atg ggt gaa ctg acc cgc atc gca gct 816 Gln Glu Asp Ala Glu Ala Ala Met Gly Glu Leu Thr Arg Ile Ala Ala             260 265 270 ggc ggc acc ctg gca act gtg aac aat ggc acc gct acc tgg gaa acc 864 Gly Gly Thr Leu Ala Thr Val Asn Asn Gly Thr Ala Thr Trp Glu Thr         275 280 285 tcc gtc gat gcc ggc gtc atc gct gac tac aac aac gtc acc gca ggc 912 Ser Val Asp Ala Gly Val Ile Ala Asp Tyr Asn Asn Val Thr Ala Gly     290 295 300 tac ctg cca gca tcc gtt gtt cct gca cac acc gca cct gac gtg ctg 960 Tyr Leu Pro Ala Ser Val Val Pro Ala His Thr Ala Pro Asp Val Leu 305 310 315 320 gtt ggc cgc gca tgg cca gca gtt ttc gct gcc gta aag tcc gca gtc 1008 Val Gly Arg Ala Trp Pro Ala Val Phe Ala Ala Val Lys Ser Ala Val                 325 330 335 atc cca ggc acc gat tcc gca tcc gtt gtg gaa ggc atg ctg tcc ctg 1056 Ile Pro Gly Thr Asp Ser Ala Ser Val Val Glu Gly Met Leu Ser Leu             340 345 350 gtt cac ctg gag cac cac att gtg ctc aag tcc gat gtc cca acc gac 1104 Val His Leu Glu His His Ile Val Leu Lys Ser Asp Val Pro Thr Asp         355 360 365 ggc gcg ctg aag gtt tcc gcg act gcc gat gag gta gtc gat acc gac 1152 Gly Ala Leu Lys Val Ser Ala Thr Ala Asp Glu Val Val Asp Thr Asp     370 375 380 ctg ggt cgc ctc gtg atc gtg cgc gca gaa atc gcc gac gca gaa ggc 1200 Leu Gly Arg Leu Val Ile Val Arg Ala Glu Ile Ala Asp Ala Glu Gly 385 390 395 400 aac ctg att gct acg ttg gct gag cgt ttc gcg atc cgc gga cgc aag 1248 Asn Leu Ile Ala Thr Leu Ala Glu Arg Phe Ala Ile Arg Gly Arg Lys                 405 410 415 ggc aac gct gtc gca cgc acc aac acc tcc gca ctg cca acc acc gtg 1296 Gly Asn Ala Val Ala Arg Thr Asn Thr Ser Ala Leu Pro Thr Thr Val             420 425 430 gac acc cca cgc tca gct cgc gca gtg gca acc gtt gtt gca cct gaa 1344 Asp Thr Pro Arg Ser Ala Arg Ala Val Ala Thr Val Val Ala Pro Glu         435 440 445 tcc atg cgc cca ttc gct gtg atc tcc ggt gac cgc aac cca att cac 1392 Ser Met Arg Pro Phe Ala Val Ile Ser Gly Asp Arg Asn Pro Ile His     450 455 460 gtc tct gat gtt gcg gct tcc ctg gct ggt ctg cca ggt gtg atc gtg 1440 Val Ser Asp Val Ala Ala Ser Leu Ala Gly Leu Pro Gly Val Ile Val 465 470 475 480 cac ggc atg tgg acc tct gcc atc ggt gaa ctg atc gcc ggt gca gca 1488 His Gly Met Trp Thr Ser Ala Ile Gly Glu Leu Ile Ala Gly Ala Ala                 485 490 495 ttc aac gat gag cag atc caa act ccc gca gcc aag gtc gtg gaa tac 1536 Phe Asn Asp Glu Gln Ile Gln Thr Pro Ala Ala Lys Val Val Glu Tyr             500 505 510 acc gca acc atg ctg gca cca gtt ctt cca ggt gaa gaa att gag ttc 1584 Thr Ala Thr Met Leu Ala Pro Val Leu Pro Gly Glu Glu Ile Glu Phe         515 520 525 agc gtt gag cgc tcc gca gtg gac aac cgc cca gga atg gga gag gtc 1632 Ser Val Glu Arg Ser Ala Val Asp Asn Arg Pro Gly Met Gly Glu Val     530 535 540 cgc acc gtt acc gca acc gtc aac ggc aac tta gtg ctt acc gcc acc 1680 Arg Thr Val Thr Ala Thr Val Asn Gly Asn Leu Val Leu Thr Ala Thr 545 550 555 560 gct gtt gtg gca gct cca tct act ttc tac gca ttc cca ggc cag ggc 1728 Ala Val Val Ala Ala Pro Ser Thr Phe Tyr Ala Phe Pro Gly Gln Gly                 565 570 575 att cag tcc cag ggc atg ggt atg gaa gca cgc cgt aac tct cag gca 1776 Ile Gln Ser Gln Gly Met Gly Met Glu Ala Arg Arg Asn Ser Gln Ala             580 585 590 gct cgc gct atc tgg gac cgc gcc gat gca cac acc cgc aat aag ctg 1824 Ala Arg Ala Ile Trp Asp Arg Ala Asp Ala His Thr Arg Asn Lys Leu         595 600 605 ggc ttc tcc atc gtg gaa atc gtg gaa aac aac cca cgc gaa gta acc 1872 Gly Phe Ser Ile Val Glu Ile Val Glu Asn Asn Pro Arg Glu Val Thr     610 615 620 gtg gca ggg gag aag ttc ttc cac cca gac ggc gtt ttg tac ctc acc 1920 Val Ala Gly Glu Lys Phe Phe His Pro Asp Gly Val Leu Tyr Leu Thr 625 630 635 640 cag ttc acc cag gtg ggc atg gca act ctg ggc gtt gct cag atc gct 1968 Gln Phe Thr Gln Val Gly Met Ala Thr Leu Gly Val Ala Gln Ile Ala                 645 650 655 gaa atg cgt gaa gca cat gcc ttg aac cag cgt gca tac ttt gct gga 2016 Glu Met Arg Glu Ala His Ala Leu Asn Gln Arg Ala Tyr Phe Ala Gly             660 665 670 cac tcc gtt ggt gag tac aac gcg ctt gct gca tat gct ggt gtg ctg 2064 His Ser Val Gly Glu Tyr Asn Ala Leu Ala Ala Tyr Ala Gly Val Leu         675 680 685 tcc ctg gaa tcc gtt ctg gag atc gtt tac cgt cgt ggc ttg acc atg 2112 Ser Leu Glu Ser Val Leu Glu Ile Val Tyr Arg Arg Gly Leu Thr Met     690 695 700 cac cgc ttg gtg gat cgc gat gaa aac ggt ctg tcc aac tac gcg ctc 2160 His Arg Leu Val Asp Arg Asp Glu Asn Gly Leu Ser Asn Tyr Ala Leu 705 710 715 720 gca gct ctt cgc ccc aac aag atg ggt ctg acc gca gac aac gtt ttc 2208 Ala Ala Leu Arg Pro Asn Lys Met Gly Leu Thr Ala Asp Asn Val Phe                 725 730 735 gat tac gtt gcg tct gtt tcc gaa gct tcc ggt gaa ttc ctg gag atc 2256 Asp Tyr Val Ala Ser Val Ser Glu Ala Ser Gly Glu Phe Leu Glu Ile             740 745 750 gtt aac tac aac ttg gct ggc ctg cag tac gca gtt gct gga acc cag 2304 Val Asn Tyr Asn Leu Ala Gly Leu Gln Tyr Ala Val Ala Gly Thr Gln         755 760 765 gct ggt ctt gcc gcc ctt cgt gcc gat gtt gag aac cgt gca cca ggt 2352 Ala Gly Leu Ala Ala Leu Arg Ala Asp Val Glu Asn Arg Ala Pro Gly     770 775 780 cag cgt gcc ttc att ttg atc cct ggc att gac gtg cca ttc cac tcc 2400 Gln Arg Ala Phe Ile Leu Ile Pro Gly Ile Asp Val Pro Phe His Ser 785 790 795 800 tcc aag ctg cgc gac ggt gtg ggc gcg ttc cgt gag cac ctt gat tcc 2448 Ser Lys Leu Arg Asp Gly Val Gly Ala Phe Arg Glu His Leu Asp Ser                 805 810 815 ctg atc cca gct gag ctg gat ctg gat gtg ctg gtt ggc cgc tac att 2496 Leu Ile Pro Ala Glu Leu Asp Leu Asp Val Leu Val Gly Arg Tyr Ile             820 825 830 cca aac ttg gtg gct cgc cca ttc gaa ctc act gaa gag ttc gtg gca 2544 Pro Asn Leu Val Ala Arg Pro Phe Glu Leu Thr Glu Glu Phe Val Ala         835 840 845 tcc atg gca gaa gtg gtg gag tcc acc tat gtc aat gag atc ttg gct 2592 Ser Met Ala Glu Val Val Glu Ser Thr Tyr Val Asn Glu Ile Leu Ala     850 855 860 gat ttc aag gct gct tcc gcc gat aag cag aag ctt gcc cgc acg ttg 2640 Asp Phe Lys Ala Ala Ser Ala Asp Lys Gln Lys Leu Ala Arg Thr Leu 865 870 875 880 ctt att gag ctg ctt gca tgg cag ttc gca tca cct gtg cgc tgg atc 2688 Leu Ile Glu Leu Leu Ala Trp Gln Phe Ala Ser Pro Val Arg Trp Ile                 885 890 895 gag act cag gat ctg ttg atc aag ggc ctt caa gct gag cgt ttc gtg 2736 Glu Thr Gln Asp Leu Leu Ile Lys Gly Leu Gln Ala Glu Arg Phe Val             900 905 910 gag gtc ggt gtt ggc tct gct cca acg ctt gcc aac atg atg ggc cag 2784 Glu Val Gly Val Gly Ser Ala Pro Thr Leu Ala Asn Met Met Gly Gln         915 920 925 acc ctg cgc ctt cct cag tac gcg gac gcc acc att gag gtg tta aac 2832 Thr Leu Arg Leu Pro Gln Tyr Ala Asp Ala Thr Ile Glu Val Leu Asn     930 935 940 att gag cgc gat cgc cca gtt gtg ttc gct acc gat gag gtt gtg cgt 2880 Ile Glu Arg Asp Arg Pro Val Val Phe Ala Thr Asp Glu Val Val Arg 945 950 955 960 gaa gtg gcg gtt gaa gag acc cca gca gct cct gca gaa acc act gaa 2928 Glu Val Ala Val Glu Glu Thr Pro Ala Ala Pro Ala Glu Thr Thr Glu                 965 970 975 acc cca gca acc cca gca acc cca gcc cct gtt gca gct gca gcc cct 2976 Thr Pro Ala Thr Pro Ala Thr Pro Ala Pro Val Ala Ala Ala Ala Pro             980 985 990 gcc acc ggc ggc cct cgc cca gat gac atc agc ttc act cct tct gat 3024 Ala Thr Gly Gly Pro Arg Pro Asp Asp Ile Ser Phe Thr Pro Ser Asp         995 1000 1005 gcc act gaa atg ctc atc gct atc tgg acc aag gtt cgc cca gat cag 3072 Ala Thr Glu Met Leu Ile Ala Ile Trp Thr Lys Val Arg Pro Asp Gln     1010 1015 1020 atg ggt gcc act gat tcc atc gag acc ctg gtt gag ggc gtg tcc tct 3 120 Met Gly Ala Thr Asp Ser Ile Glu Thr Leu Val Glu Gly Val Ser Ser 1025 1030 1035 1040 cgc cgt aac cag ctc ctg ctg gat ctt ggt gtg gag ttc ggc ctc ggc 3168 Arg Arg Asn Gln Leu Leu Leu Asp Leu Gly Val Glu Phe Gly Leu Gly                 1045 1050 1055 gca att gac gga gca gcc gat gct gag ctc ggt gat cta aag gtc acc 3216 Ala Ile Asp Gly Ala Ala Asp Ala Glu Leu Gly Asp Leu Lys Val Thr             1060 1065 1070 gtg tcc aag atg gct aag ggc tac aag gcg ttt ggc cct gtg ctc tcc 3264 Val Ser Lys Met Ala Lys Gly Tyr Lys Ala Phe Gly Pro Val Leu Ser         1075 1080 1085 gat gct gca gct gat gcc ctg cgt cgc ctc act ggt cct acc ggt aag 3312 Asp Ala Ala Ala Asp Ala Leu Arg Arg Leu Thr Gly Pro Thr Gly Lys     1090 1095 1100 cgc ccg gga tac atc gca gag cgc gtc acc ggc acg tgg gaa ttg ggc 3360 Arg Pro Gly Tyr Ile Ala Glu Arg Val Thr Gly Thr Trp Glu Leu Gly 1105 1110 1115 1120 cag ggc tgg gct gac cac gtg gtc gct gaa gtt gtg atc ggc gcc cgc 3408 Gln Gly Trp Ala Asp His Val Val Ala Glu Val Val Ile Gly Ala Arg                 1125 1130 1135 gaa ggc gca tcc ctg cgc ggc ggc gac ctg gcg tca ctg tct cct gca 3456 Glu Gly Ala Ser Leu Arg Gly Gly Asp Leu Ala Ser Leu Ser Pro Ala             1140 1145 1150 agc cca gcg tct gca tca gat ctt gat tcg ctt atc gac gca gcc gtc 3504 Ser Pro Ala Ser Ala Ser Asp Leu Asp Ser Leu Ile Asp Ala Ala Val         1155 1160 1165 cag gcc gta gcc tcc cgc cgc ggc gtt gcg gtc tcc ctg cct tca gca 3552 Gln Ala Val Ala Ser Arg Arg Gly Val Ala Val Ser Leu Pro Ser Ala     1170 1175 1180 ggc ggc gct gcc ggt ggc gtg gtt gat tcc gca gct ctt ggc gag ttt 3600 Gly Gly Ala Ala Gly Gly Val Val Asp Ser Ala Ala Leu Gly Glu Phe 1185 1190 1195 1200 gca gag cag gtc acc gga cac gat ggt gtg ctt gct cag gca gcc cgc 3648 Ala Glu Gln Val Thr Gly His Asp Gly Val Leu Ala Gln Ala Ala Arg                 1205 1210 1215 acc atc ttg acc cag ttg ggt ctt gat aag cca gca acc gtt tcc gtg 3696 Thr Ile Leu Thr Gln Leu Gly Leu Asp Lys Pro Ala Thr Val Ser Val             1220 1225 1230 gaa gac acc gca gag gaa gac ctc tac gag ttg gtc tcc aag gaa ctc 3744 Glu Asp Thr Ala Glu Glu Asp Leu Tyr Glu Leu Val Ser Lys Glu Leu         1235 1240 1245 ggt tct gat tgg cca cgt cag gtt gca cca agc ttc gat gaa gaa aag 3792 Gly Ser Asp Trp Pro Arg Gln Val Ala Pro Ser Phe Asp Glu Glu Lys     1250 1255 1260 gtt gtt ctg ctt gat gac cgt tgg gct tct gcg cgt gag 3831 Val Val Leu Leu Asp Asp Arg Trp Ala Ser Ala Arg Glu 1265 1270 1275 <210> 54 <211> 1277 <212> PRT <213> Corynebacterium glutamicum <400> 54 Gln Trp Leu Asn Arg Tyr Leu Glu Leu Ser Gly Pro Val Asp Gly Gln   1 5 10 15 Trp Ile Asp Ala Ser Trp Ala Ala Arg Phe Ala Gln Met Leu Glu Arg              20 25 30 Ala Glu Ala Arg Leu Ile Glu Gln Asp His Gly Gln Phe Glu Pro Ser          35 40 45 Leu Thr Val Glu Asp Gly Val Asp Lys Leu Val Ala Ala Tyr Pro His      50 55 60 Ala Ala Thr Asp Leu Leu Thr Pro Ala Asp Val Ala Trp Phe Leu Gly  65 70 75 80 Leu Cys Arg Thr Pro Gly Lys Pro Val Asn Phe Val Pro Val Ile Asp                  85 90 95 Lys Asp Val Arg Arg Trp Trp Arg Ser Asp Ser Leu Trp Gln Ser His             100 105 110 Asp Asp Arg Tyr Thr Ala Asp Gln Val Ala Ile Ile Pro Gly Val Val         115 120 125 Ala Val Ala Gly Ile Thr Lys Ala Asn Glu Pro Val Ala Asp Leu Leu     130 135 140 Asp Arg Phe Val Asp Ala Thr Ile Glu Arg Ile Asp Glu His Asp Ser 145 150 155 160 Arg Ser Arg Asp Ile Met Gly Lys Val Leu Ser Ser Pro Gly Thr Phe                 165 170 175 Trp Ala Gly Arg Asn Ile Pro Ser Val Ile His Ser Leu Gly His Ala             180 185 190 Asp Lys Trp Ser Arg Ser Glu Phe Glu Ala Phe His Ser Pro Thr Gly         195 200 205 Ala Asn Leu Val Tyr Glu Asp Ala Glu His Ala Met Leu Thr Val Pro     210 215 220 Leu Ala Gly Ser Thr Ala Phe Gly Thr Thr Ala Glu Leu Lys Ile Arg 225 230 235 240 Phe Thr Ser Pro Ile Asp Ala Leu Pro Ser Ala Val Pro Leu Val Thr                 245 250 255 Gln Glu Asp Ala Glu Ala Ala Met Gly Glu Leu Thr Arg Ile Ala Ala             260 265 270 Gly Gly Thr Leu Ala Thr Val Asn Asn Gly Thr Ala Thr Trp Glu Thr         275 280 285 Ser Val Asp Ala Gly Val Ile Ala Asp Tyr Asn Asn Val Thr Ala Gly     290 295 300 Tyr Leu Pro Ala Ser Val Val Pro Ala His Thr Ala Pro Asp Val Leu 305 310 315 320 Val Gly Arg Ala Trp Pro Ala Val Phe Ala Ala Val Lys Ser Ala Val                 325 330 335 Ile Pro Gly Thr Asp Ser Ala Ser Val Val Glu Gly Met Leu Ser Leu             340 345 350 Val His Leu Glu His His Ile Val Leu Lys Ser Asp Val Pro Thr Asp         355 360 365 Gly Ala Leu Lys Val Ser Ala Thr Ala Asp Glu Val Val Asp Thr Asp     370 375 380 Leu Gly Arg Leu Val Ile Val Arg Ala Glu Ile Ala Asp Ala Glu Gly 385 390 395 400 Asn Leu Ile Ala Thr Leu Ala Glu Arg Phe Ala Ile Arg Gly Arg Lys                 405 410 415 Gly Asn Ala Val Ala Arg Thr Asn Thr Ser Ala Leu Pro Thr Thr Val             420 425 430 Asp Thr Pro Arg Ser Ala Arg Ala Val Ala Thr Val Val Ala Pro Glu         435 440 445 Ser Met Arg Pro Phe Ala Val Ile Ser Gly Asp Arg Asn Pro Ile His     450 455 460 Val Ser Asp Val Ala Ala Ser Leu Ala Gly Leu Pro Gly Val Ile Val 465 470 475 480 His Gly Met Trp Thr Ser Ala Ile Gly Glu Leu Ile Ala Gly Ala Ala                 485 490 495 Phe Asn Asp Glu Gln Ile Gln Thr Pro Ala Ala Lys Val Val Glu Tyr             500 505 510 Thr Ala Thr Met Leu Ala Pro Val Leu Pro Gly Glu Glu Ile Glu Phe         515 520 525 Ser Val Glu Arg Ser Ala Val Asp Asn Arg Pro Gly Met Gly Glu Val     530 535 540 Arg Thr Val Thr Ala Thr Val Asn Gly Asn Leu Val Leu Thr Ala Thr 545 550 555 560 Ala Val Val Ala Ala Pro Ser Thr Phe Tyr Ala Phe Pro Gly Gln Gly                 565 570 575 Ile Gln Ser Gln Gly Met Gly Met Glu Ala Arg Arg Asn Ser Gln Ala             580 585 590 Ala Arg Ala Ile Trp Asp Arg Ala Asp Ala His Thr Arg Asn Lys Leu         595 600 605 Gly Phe Ser Ile Val Glu Ile Val Glu Asn Asn Pro Arg Glu Val Thr     610 615 620 Val Ala Gly Glu Lys Phe Phe His Pro Asp Gly Val Leu Tyr Leu Thr 625 630 635 640 Gln Phe Thr Gln Val Gly Met Ala Thr Leu Gly Val Ala Gln Ile Ala                 645 650 655 Glu Met Arg Glu Ala His Ala Leu Asn Gln Arg Ala Tyr Phe Ala Gly             660 665 670 His Ser Val Gly Glu Tyr Asn Ala Leu Ala Ala Tyr Ala Gly Val Leu         675 680 685 Ser Leu Glu Ser Val Leu Glu Ile Val Tyr Arg Arg Gly Leu Thr Met     690 695 700 His Arg Leu Val Asp Arg Asp Glu Asn Gly Leu Ser Asn Tyr Ala Leu 705 710 715 720 Ala Ala Leu Arg Pro Asn Lys Met Gly Leu Thr Ala Asp Asn Val Phe                 725 730 735 Asp Tyr Val Ala Ser Val Ser Glu Ala Ser Gly Glu Phe Leu Glu Ile             740 745 750 Val Asn Tyr Asn Leu Ala Gly Leu Gln Tyr Ala Val Ala Gly Thr Gln         755 760 765 Ala Gly Leu Ala Ala Leu Arg Ala Asp Val Glu Asn Arg Ala Pro Gly     770 775 780 Gln Arg Ala Phe Ile Leu Ile Pro Gly Ile Asp Val Pro Phe His Ser 785 790 795 800 Ser Lys Leu Arg Asp Gly Val Gly Ala Phe Arg Glu His Leu Asp Ser                 805 810 815 Leu Ile Pro Ala Glu Leu Asp Leu Asp Val Leu Val Gly Arg Tyr Ile             820 825 830 Pro Asn Leu Val Ala Arg Pro Phe Glu Leu Thr Glu Glu Phe Val Ala         835 840 845 Ser Met Ala Glu Val Val Glu Ser Thr Tyr Val Asn Glu Ile Leu Ala     850 855 860 Asp Phe Lys Ala Ala Ser Ala Asp Lys Gln Lys Leu Ala Arg Thr Leu 865 870 875 880 Leu Ile Glu Leu Leu Ala Trp Gln Phe Ala Ser Pro Val Arg Trp Ile                 885 890 895 Glu Thr Gln Asp Leu Leu Ile Lys Gly Leu Gln Ala Glu Arg Phe Val             900 905 910 Glu Val Gly Val Gly Ser Ala Pro Thr Leu Ala Asn Met Met Gly Gln         915 920 925 Thr Leu Arg Leu Pro Gln Tyr Ala Asp Ala Thr Ile Glu Val Leu Asn     930 935 940 Ile Glu Arg Asp Arg Pro Val Val Phe Ala Thr Asp Glu Val Val Arg 945 950 955 960 Glu Val Ala Val Glu Glu Thr Pro Ala Ala Pro Ala Glu Thr Thr Glu                 965 970 975 Thr Pro Ala Thr Pro Ala Thr Pro Ala Pro Val Ala Ala Ala Ala Pro             980 985 990 Ala Thr Gly Gly Pro Arg Pro Asp Asp Ile Ser Phe Thr Pro Ser Asp         995 1000 1005 Ala Thr Glu Met Leu Ile Ala Ile Trp Thr Lys Val Arg Pro Asp Gln     1010 1015 1020 Met Gly Ala Thr Asp Ser Ile Glu Thr Leu Val Glu Gly Val Ser Ser 1025 1030 1035 1040 Arg Arg Asn Gln Leu Leu Leu Asp Leu Gly Val Glu Phe Gly Leu Gly                 1045 1050 1055 Ala Ile Asp Gly Ala Ala Asp Ala Glu Leu Gly Asp Leu Lys Val Thr             1060 1065 1070 Val Ser Lys Met Ala Lys Gly Tyr Lys Ala Phe Gly Pro Val Leu Ser         1075 1080 1085 Asp Ala Ala Ala Asp Ala Leu Arg Arg Leu Thr Gly Pro Thr Gly Lys     1090 1095 1100 Arg Pro Gly Tyr Ile Ala Glu Arg Val Thr Gly Thr Trp Glu Leu Gly 1105 1110 1115 1120 Gln Gly Trp Ala Asp His Val Val Ala Glu Val Val Ile Gly Ala Arg                 1125 1130 1135 Glu Gly Ala Ser Leu Arg Gly Gly Asp Leu Ala Ser Leu Ser Pro Ala             1140 1145 1150 Ser Pro Ala Ser Ala Ser Asp Leu Asp Ser Leu Ile Asp Ala Ala Val         1155 1160 1165 Gln Ala Val Ala Ser Arg Arg Gly Val Ala Val Ser Leu Pro Ser Ala     1170 1175 1180 Gly Gly Ala Ala Gly Gly Val Val Asp Ser Ala Ala Leu Gly Glu Phe 1185 1190 1195 1200 Ala Glu Gln Val Thr Gly His Asp Gly Val Leu Ala Gln Ala Ala Arg                 1205 1210 1215 Thr Ile Leu Thr Gln Leu Gly Leu Asp Lys Pro Ala Thr Val Ser Val             1220 1225 1230 Glu Asp Thr Ala Glu Glu Asp Leu Tyr Glu Leu Val Ser Lys Glu Leu         1235 1240 1245 Gly Ser Asp Trp Pro Arg Gln Val Ala Pro Ser Phe Asp Glu Glu Lys     1250 1255 1260 Val Val Leu Leu Asp Asp Arg Trp Ala Ser Ala Arg Glu 1265 1270 1275 <210> 55 <211> 4953 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (4930) <223> RXA02582 <400> 55 tggatgtcta ttctcctcag cctcgttttg gttgaggcgg atagttttaa tattttttta 60 agtttaagtt gtaatcgagc tgaaaggctg aggcctcaat atg gaa cag agc caa 115                                             Met Glu Gln Ser Gln                                               1 5 tcg tcg gat cag aag atg acc gtt gaa cag gtt cgc acc tgg ctc cgt 163 Ser Ser Asp Gln Lys Met Thr Val Glu Gln Val Arg Thr Trp Leu Arg                  10 15 20 gat tgg gtt gtc cgc acc acg ggt att ccg gtg gag gaa gtt acg gat 211 Asp Trp Val Val Arg Thr Thr Gly Ile Pro Val Glu Glu Val Thr Asp              25 30 35 gac aag gca atg gag acc ttt ggc ctt tcc tct cgc gat gtt gtt gtg 259 Asp Lys Ala Met Glu Thr Phe Gly Leu Ser Ser Arg Asp Val Val Val          40 45 50 ttg tct ggt gag ctg gaa aac ctg ctg gac acc tcc ttg gat gcc acc 307 Leu Ser Gly Glu Leu Glu Asn Leu Leu Asp Thr Ser Leu Asp Ala Thr      55 60 65 atc gct tat gag tac cca acg atc cgt agt ttg gcg cag cgc ctt gtt 355 Ile Ala Tyr Glu Tyr Pro Thr Ile Arg Ser Leu Ala Gln Arg Leu Val  70 75 80 85 gag ggc gag cct cgt cgt gca cat acc cag cgt gaa ttg aat ttc tcc 403 Glu Gly Glu Pro Arg Arg Ala His Thr Gln Arg Glu Leu Asn Phe Ser                  90 95 100 gcg gtg agc gat tcc cca ggt tcc cac gat att gcg gtt gtc ggt atg 451 Ala Val Ser Asp Ser Pro Gly Ser His Asp Ile Ala Val Val Gly Met             105 110 115 gct gcg cgt tac cca ggc gct gag agc ctg gag gat atg tgg aag cta 499 Ala Ala Arg Tyr Pro Gly Ala Glu Ser Leu Glu Asp Met Trp Lys Leu         120 125 130 ctc gtc gag ggc cgt gac ggt atc tcg gat cta ccg att ggc cgt tgg 547 Leu Val Glu Gly Arg Asp Gly Ile Ser Asp Leu Pro Ile Gly Arg Trp     135 140 145 tct gag tat gca ggc gat gag gtt atg tct cgg aag atg gaa gag ttt 595 Ser Glu Tyr Ala Gly Asp Glu Val Met Ser Arg Lys Met Glu Glu Phe 150 155 160 165 tct acc atc ggt ggc tac ctg tca gat atc tct agc ttt gat gcg gag 643 Ser Thr Ile Gly Gly Tyr Leu Ser Asp Ile Ser Ser Phe Asp Ala Glu                 170 175 180 ttc ttt ggt ctg tct ccg ctc gag gcc gcc aac atg gat cct cag cag 691 Phe Phe Gly Leu Ser Pro Leu Glu Ala Ala Asn Met Asp Pro Gln Gln             185 190 195 cgt att ttg ctg gag cta acg tgg gag gct ttg gag tac gct cgc atc 739 Arg Ile Leu Leu Glu Leu Thr Trp Glu Ala Leu Glu Tyr Ala Arg Ile         200 205 210 gca cca aac act ttg cgt ggc gaa gcc gtg ggc gtg ttc ata ggt tcc 787 Ala Pro Asn Thr Leu Arg Gly Glu Ala Val Gly Val Phe Ile Gly Ser     215 220 225 tcc aac aac gat tac ggc atg atg atc gct gcc gat cca gca gaa gca 835 Ser Asn Asn Asp Tyr Gly Met Met Ile Ala Ala Asp Pro Ala Glu Ala 230 235 240 245 cat cct tat gcg ctg act ggt act tct agt gcg att gtc gct aac cgc 883 His Pro Tyr Ala Leu Thr Gly Thr Ser Ser Ala Ile Val Ala Asn Arg                 250 255 260 att aac tac gct ttc gat ttc cgc ggt cct tcc gtc aac gtg gat acc 931 Ile Asn Tyr Ala Phe Asp Phe Arg Gly Pro Ser Val Asn Val Asp Thr             265 270 275 gca tgt tct tct tct ctg gta gcg gtt cac cag gct gtc cgt gcg ctg 979 Ala Cys Ser Ser Ser Le Le Val Ala Val His Gln Ala Val Arg Ala Leu         280 285 290 cgt aat ggc gaa gcg gat cac gct atc gct ggt gga gtg aac att ttg 1027 Arg Asn Gly Glu Ala Asp His Ala Ile Ala Gly Gly Val Asn Ile Leu     295 300 305 gca tct cca ttt gtc aca act gca ttc gct gag ctc ggt gtg atc agc 1075 Ala Ser Pro Phe Val Thr Thr Ala Phe Ala Glu Leu Gly Val Ile Ser 310 315 320 325 cca acc ggc aag atc cac gca ttc tct gat gat gcc gat ggt ttc gtg 1123 Pro Thr Gly Lys Ile His Ala Phe Ser Asp Asp Ala Asp Gly Phe Val                 330 335 340 cgt tcc gac ggc gcc gga gtc gtt gtg ctg aag cgc gtg gat gac gca 1171 Arg Ser Asp Gly Ala Gly Val Val Val Leu Lys Arg Val Asp Asp Ala             345 350 355 atc cgc gac ggc gac aag atc atc ggt gtg atc aag ggt tct gca gtg 1219 Ile Arg Asp Gly Asp Lys Ile Ile Gly Val Ile Lys Gly Ser Ala Val         360 365 370 aac tcc gat ggt cac tcc aac gga ctg acc gct cca aac cct gac gca 1267 Asn Ser Asp Gly His Ser Asn Gly Leu Thr Ala Pro Asn Pro Asp Ala     375 380 385 cag gtt gat gtg ctg cag cgt gca tat gtt gac gct cag gtt gat ccc 1315 Gln Val Asp Val Leu Gln Arg Ala Tyr Val Asp Ala Gln Val Asp Pro 390 395 400 405 acc acc gtg gat tac gtt gag gct cac ggc acc ggc acc atc ctg ggt 1363 Thr Thr Val Asp Tyr Val Glu Ala His Gly Thr Gly Thr Ile Leu Gly                 410 415 420 gac ccc att gaa gca act gcc ctg ggt gct gtt ttg ggc tat ggc cgt 1411 Asp Pro Ile Glu Ala Thr Ala Leu Gly Ala Val Leu Gly Tyr Gly Arg             425 430 435 gac gca tcc acc cca act ctt ctg ggc tct gca aag tcc aac ttc ggc 1459 Asp Ala Ser Thr Pro Thr Leu Leu Gly Ser Ala Lys Ser Asn Phe Gly         440 445 450 cac act gag tca gct gcg ggt att gca ggt gtc atc aag gtg ctg ctt 1507 His Thr Glu Ser Ala Ala Gly Ile Ala Gly Val Ile Lys Val Leu Leu     455 460 465 gct ttg cag aac aag act ctg cca cca acc gtg aac ttt gca ggt cca 1555 Ala Leu Gln Asn Lys Thr Leu Pro Pro Thr Val Asn Phe Ala Gly Pro 470 475 480 485 aac cgc tac atc gat ttc gat gct gag cgt ttg gaa gtt gtg gaa gat 1603 Asn Arg Tyr Ile Asp Phe Asp Ala Glu Arg Leu Glu Val Val Glu Asp                 490 495 500 cca cgt gaa tgg ccg gaa tac aac ggt cac gca gta gct ggt gtg tct 1651 Pro Arg Glu Trp Pro Glu Tyr Asn Gly His Ala Val Ala Gly Val Ser             505 510 515 gcg ttc ggg ttc ggt gga acc aac gcg cac gtg gtg atc tct gag tac 1699 Ala Phe Gly Phe Gly Gly Thr Asn Ala His Val Val Ile Ser Glu Tyr         520 525 530 aac gca gaa gac tac gaa acc cgt gcc ccg aag gag gcg ttg ctt cct 1747 Asn Ala Glu Asp Tyr Glu Thr Arg Ala Pro Lys Glu Ala Leu Leu Pro     535 540 545 gac cag cag gtt gcc ctg ccg gtg tct ggt cac ctg cca tcc agg cgt 1795 Asp Gln Gln Val Ala Leu Pro Val Ser Gly His Leu Pro Ser Arg Arg 550 555 560 565 cga caa gca gct gct gac ttg gcg gac ttc ttg gag ggc cgc aaa gat 1843 Arg Gln Ala Ala Ala Asp Leu Ala Asp Phe Leu Glu Gly Arg Lys Asp                 570 575 580 tgc gac cta acc cca gta gcc cgc gcg ctg gca ggc cgc aat cat ggc 1891 Cys Asp Leu Thr Pro Val Ala Arg Ala Leu Ala Gly Arg Asn His Gly             585 590 595 cgc tcc cgc gca gtc gtg ctt gca agc act atc gag gaa gcc gta aag 1939 Arg Ser Arg Ala Val Val Leu Ala Ser Thr Ile Glu Glu Ala Val Lys         600 605 610 cgc ctg cgc cag gtc gca gaa ggc aag gtc agc gtc ggt atc tcc gca 1987 Arg Leu Arg Gln Val Ala Glu Gly Lys Val Ser Val Gly Ile Ser Ala     615 620 625 gct gat tcc cca gcg gcc aac ggt cct gtg ttt gtg tac tcc ggt ttc 2035 Ala Asp Ser Pro Ala Ala Asn Gly Pro Val Phe Val Tyr Ser Gly Phe 630 635 640 645 gga tcc cag cac cgc ctc atg atc aag gaa ttg tgc tca att tcg cca 2083 Gly Ser Gln His Arg Leu Met Ile Lys Glu Leu Cys Ser Ile Ser Pro                 650 655 660 cag ttc cgc gag cgc atc gaa gag ctc gat gaa atg gtt aag ttc gag 2131 Gln Phe Arg Glu Arg Ile Glu Glu Leu Asp Glu Met Val Lys Phe Glu             665 670 675 tcc ggc tgg tcc atc atg aaa ctt gtt ttg gat gat gag caa act tac 2179 Ser Gly Trp Ser Ile Met Lys Leu Val Leu Asp Asp Glu Gln Thr Tyr         680 685 690 gac acc gag acc gcg cag gtt gtg atc acc gca atc cag atc gca ctg 2227 Asp Thr Glu Thr Ala Gln Val Val Ile Thr Ala Ile Gln Ile Ala Leu     695 700 705 act gac ctg ttg gca agc ttc ggt gta aag cca gct gcc gtc atg ggc 2275 Thr Asp Leu Leu Ala Ser Phe Gly Val Lys Pro Ala Ala Val Met Gly 710 715 720 725 atg tcg atg ggt gag atc gct gcc gct tac gct gcc ggt gga ctc agc 2323 Met Ser Met Gly Glu Ile Ala Ala Ala Tyr Ala Ala Gly Gly Leu Ser                 730 735 740 gac cgc gat acc atg ctc att gcc agc cac cgt tcc cgc cta atg ggc 2371 Asp Arg Asp Thr Met Leu Ile Ala Ser His Arg Ser Arg Leu Met Gly             745 750 755 gag ggc gag aag tcc ctg gct gag gat cag ctg ggt gcc atg gct gtg 2419 Glu Gly Glu Lys Ser Leu Ala Glu Asp Gln Leu Gly Ala Met Ala Val         760 765 770 gtg gaa ttc gcc gct gcg gac ctg gat aag ttc atc gaa gaa aac cct 2467 Val Glu Phe Ala Ala Ala Asp Leu Asp Lys Phe Ile Glu Glu Asn Pro     775 780 785 gag tac aag ggc att gag cct gct gtt tat gca ggc cca ggc atg act 2515 Glu Tyr Lys Gly Ile Glu Pro Ala Val Tyr Ala Gly Pro Gly Met Thr 790 795 800 805 acc gtg ggt gga cct cgc gac gcc gtg gtt cag ttc gta gag aag ctg 2563 Thr Val Gly Gly Pro Arg Asp Ala Val Val Gln Phe Val Glu Lys Leu                 810 815 820 gaa tct gaa gac aag ttt gcc cgc ctg ctc aac gtc aag ggc gct ggc 2611 Glu Ser Glu Asp Lys Phe Ala Arg Leu Leu Asn Val Lys Gly Ala Gly             825 830 835 cac acc tct gct gtg gaa cca ctt ctt ggt gag ctc gct ggc gaa atc 2659 His Thr Ser Ala Val Glu Pro Leu Leu Gly Glu Leu Ala Gly Glu Ile         840 845 850 gct ggc atc gag cca ctt ccg ctg cag atc ccg ttg ttc agc tct gtc 2707 Ala Gly Ile Glu Pro Leu Pro Leu Gln Ile Pro Leu Phe Ser Ser Val     855 860 865 gat cag ggt gtt acc tac cca gtt gga gca gtg gtc cac gac gcc gat 2755 Asp Gln Gly Val Thr Tyr Pro Val Gly Ala Val Val His Asp Ala Asp 870 875 880 885 tac atg ctc cgc tgt acc cgc cag tcc gtg tac ttc cag gac tcc acc 2803 Tyr Met Leu Arg Cys Thr Arg Gln Ser Val Tyr Phe Gln Asp Ser Thr                 890 895 900 gaa gct gca ttc gct gca ggc cac aac acc ttg gtg gaa att tcc ccg 2851 Glu Ala Ala Phe Ala Ala Gly His Asn Thr Leu Val Glu Ile Ser Pro             905 910 915 aac cca gtt gca ctc atg ggc atg atg aac acc gcg ttc acc gtg ggc 2899 Asn Pro Val Ala Leu Met Gly Met Met Asn Thr Ala Phe Thr Val Gly         920 925 930 aag cct gat gca cag ctg ctg ttc agc ctg aag cga aaa gtc cca gag 2947 Lys Pro Asp Ala Gln Leu Leu Phe Ser Leu Lys Arg Lys Val Pro Glu     935 940 945 gca gaa tcc ctc cgc gac ctt ctg gcg aag ctg tac gtc aac ggc gca 2995 Ala Glu Ser Leu Arg Asp Leu Leu Ala Lys Leu Tyr Val Asn Gly Ala 950 955 960 965 aac gtt gat ttc tcc gcg ctg tac ggc gaa ggt gaa acc atc gat ccg 3043 Asn Val Asp Phe Ser Ala Leu Tyr Gly Glu Gly Glu Thr Ile Asp Pro                 970 975 980 cca cac atc acc tgg aag cac cag cgc ttc tgg act tcc gca cgc cca 3091 Pro His Ile Thr Trp Lys His Gln Arg Phe Trp Thr Ser Ala Arg Pro             985 990 995 tcc tct ggc gca tcc ctg gat ctg ccg ggc ttc cgc gtg aat ctg cca 3139 Ser Ser Gly Ala Ser Leu Asp Leu Pro Gly Phe Arg Val Asn Leu Pro         1000 1005 1010 aac aac act gtg gcg ttt tcc acc gca gcc gaa ctg gca cca tcc gca 3187 Asn Asn Thr Val Ala Phe Ser Thr Ala Ala Glu Leu Ala Pro Ser Ala     1015 1020 1025 gtg gca atc atg gaa gca gcc gcc atg gct gtc acc cca ggt tcc tcc 3235 Val Ala Ile Met Glu Ala Ala Ala Met Ala Val Thr Pro Gly Ser Ser 1030 1035 1040 1045 gtc gac gca gtg gac gag cgc gac atg ctg cca cca agc ggc gaa atc 3283 Val Asp Ala Val Asp Glu Arg Asp Met Leu Pro Pro Ser Gly Glu Ile                 1050 1055 1060 acc acc atc gtg act cgc tcc ttg ggc ggt ttg agc ctg tcc gta tac 3331 Thr Thr Ile Val Thr Arg Ser Leu Gly Gly Leu Ser Leu Ser Val Tyr             1065 1070 1075 aag att gag gga acc acc agc act ctt gtc gcc gaa ggt ttc gca gcc 3379 Lys Ile Glu Gly Thr Thr Ser Thr Leu Val Ala Glu Gly Phe Ala Ala         1080 1085 1090 aac cca gga ttc gcc gca gca tct tcc ttc gac ggt cca ggc tac gac 3427 Asn Pro Gly Phe Ala Ala Ala Ser Ser Phe Asp Gly Pro Gly Tyr Asp     1095 1100 1105 gga ttc aac acc gat tac agc gac cag cca gac cct cgc tcc gac ctg 3475 Gly Phe Asn Thr Asp Tyr Ser Asp Gln Pro Asp Pro Arg Ser Asp Leu 1110 1115 1120 1125 cct ttg gac atc gaa gca gtc cgc tgg gac cca gcg acc gaa acc gtc 3523 Pro Leu Asp Ile Glu Ala Val Arg Trp Asp Pro Ala Thr Glu Thr Val                 1130 1135 1140 gaa gag cgc atg cgc gcc atc gtc tcc gaa gca atg ggc tac gac gtg 3571 Glu Glu Arg Met Arg Ala Ile Val Ser Glu Ala Met Gly Tyr Asp Val             1145 1150 1155 gat gac ctc cca cgc gaa ctc cca ctg att gac ctc ggc ctc gac tcc 3619 Asp Asp Leu Pro Arg Glu Leu Pro Leu Ile Asp Leu Gly Leu Asp Ser         1160 1165 1170 ctc atg ggc atg cgc atc aaa aac cgc atc gaa aat gac ttc cag atc 3667 Leu Met Gly Met Arg Ile Lys Asn Arg Ile Glu Asn Asp Phe Gln Ile     1175 1180 1185 cca cca ctc cag gtc caa gcg ctc cgc gat gca tcc gtc gct gac gtg 3715 Pro Pro Leu Gln Val Gln Ala Leu Arg Asp Ala Ser Val Ala Asp Val 1190 1195 1200 1205 gta atc atg gtg gaa aac atg gtc gct ggc cgc tcc tct gag acg ctt 3763 Val Ile Met Val Glu Asn Met Val Ala Gly Arg Ser Ser Glu Thr Leu                 1210 1215 1220 gtc gac gcc acc ccg cag gtg cca gct gag gca gca ggg gag gct caa 3811 Val Asp Ala Thr Pro Gln Val Pro Ala Glu Ala Ala Gly Glu Ala Gln             1225 1230 1235 gct gct gag tct tct gct tcg ggc gag gac gtg cag ggc gtt ggc gtt 3859 Ala Ala Glu Ser Ser Ala Ser Gly Glu Asp Val Gln Gly Val Gly Val         1240 1245 1250 gca ccg cga gat gcg tcg gaa cgc atg gtc ttt ggt act tgg gca ggc 3907 Ala Pro Arg Asp Ala Ser Glu Arg Met Val Phe Gly Thr Trp Ala Gly     1255 1260 1265 ctg act ggc gct gcg gca gct ggc gtg acc agc aag ttg cca cag atc 3955 Leu Thr Gly Ala Ala Ala Ala Gly Val Thr Ser Ser Lys Leu Pro Gln Ile 1270 1275 1280 1285 gat gtc gat act gca acc gca att gcc gag cgc ctc acc gag cgt tcc 4003 Asp Val Asp Thr Ala Thr Ala Ile Ala Glu Arg Leu Thr Glu Arg Ser                 1290 1295 1300 gga att gaa atc agc act gaa cag gtg ttg gct gca gaa acc ctc gaa 4051 Gly Ile Glu Ile Ser Thr Glu Gln Val Leu Ala Ala Glu Thr Leu Glu             1305 1310 1315 cca ctg tct gac ctg gtg cgt gaa ggc ctc gaa act gaa gtt cag ggc 4099 Pro Leu Ser Asp Leu Val Arg Glu Gly Leu Glu Thr Glu Val Gln Gly         1320 1325 1330 aac att cgt gtg ctg cgt gga cgt gca gaa ggc tcc acc aag cct gca 4147 Asn Ile Arg Val Leu Arg Gly Arg Ala Glu Gly Ser Thr Lys Pro Ala     1335 1340 1345 gtg ttc atg ttc cac cca gct ggc ggt tct tcc gtg gtc tac caa cca 4195 Val Phe Met Phe His Pro Ala Gly Gly Ser Ser Val Val Tyr Gln Pro 1350 1355 1360 1365 cta atg cgt cgt ctg cct gaa gat gtc cct gtc tat ggc gtt gag cgt 4243 Leu Met Arg Arg Leu Pro Glu Asp Val Pro Val Tyr Gly Val Glu Arg                 1370 1375 1380 ctg gaa ggc gat ctc gct gac cgc gcg gca gca tat gtt gat gac atc 4291 Leu Glu Gly Asp Leu Ala Asp Arg Ala Ala Ala Tyr Val Asp Asp Ile             1385 1390 1395 aag aag tac tcc gat ggc ttc cca gta gtt ttg ggt ggc tgg agc ttc 4339 Lys Lys Tyr Ser Asp Gly Phe Pro Val Val Leu Gly Gly Trp Ser Phe         1400 1405 1410 ggc ggt gcc gtt gcc ttc gag gtt gcc cac caa ctg gtt ggc tcc gat 4387 Gly Gly Ala Val Ala Phe Glu Val Ala His Gln Leu Val Gly Ser Asp     1415 1420 1425 gtt gag gta gct acc gtg gcg ttg ctg gat act gtg cag cct tca aac 4435 Val Glu Val Ala Thr Val Ala Leu Leu Asp Thr Val Gln Pro Ser Asn 1430 1435 1440 1445 cca gca cca gat acc gct gag gaa act cgt gca cgc tgg act cgc tac 4483 Pro Ala Pro Asp Thr Ala Glu Glu Thr Arg Ala Arg Trp Thr Arg Tyr                 1450 1455 1460 gcg gac ttc gcc aag aag acc tac ggc ctt gat ttc gag gta cct ttt 4531 Ala Asp Phe Ala Lys Lys Thr Tyr Gly Leu Asp Phe Glu Val Pro Phe             1465 1470 1475 gaa atc ttg gac acc atc ggt gaa gac gga atg ctg tcc atg atg acc 4579 Glu Ile Leu Asp Thr Ile Gly Glu Asp Gly Met Leu Ser Met Met Thr         1480 1485 1490 gac ttc ctg gcc aac acc gac gcc tcc gag cac gga ttg tcc gca ggt 4627 Asp Phe Leu Ala Asn Thr Asp Ala Ser Glu His Gly Leu Ser Ala Gly     1495 1500 1505 gtg ctt gaa cac cag cgc gct tct ttt gtg gac aac cgc atc ctg gct 4675 Val Leu Glu His Gln Arg Ala Ser Phe Val Asp Asn Arg Ile Leu Ala 1510 1515 1520 1525 aaa ctt aat ttt gca gac tgg gcc aac gtt gaa gcc cct gtc atc ctg 4723 Lys Leu Asn Phe Ala Asp Trp Ala Asn Val Glu Ala Pro Val Ile Leu                 1530 1535 1540 ttc cgc gcg gaa cgc atg cat gat gga gct atc gaa ctt gaa cca aac 4771 Phe Arg Ala Glu Arg Met His Asp Gly Ala Ile Glu Leu Glu Pro Asn             1545 1550 1555 tat gcc aag att gat caa gat gga gga tgg tcc gga att gtc aac gat 4819 Tyr Ala Lys Ile Asp Gln Asp Gly Gly Trp Ser Gly Ile Val Asn Asp         1560 1565 1570 ttg gaa att gtt cag ctg aat ggt gac cac ctg gca gtt gtc gat gaa 4867 Leu Glu Ile Val Gln Leu Asn Gly Asp His Leu Ala Val Val Asp Glu     1575 1580 1585 cca gaa atc ggc aca gtc gga gct cat ttg agt cgc cgc att gat gag 4915 Pro Glu Ile Gly Thr Val Gly Ala His Leu Ser Arg Arg Ile Asp Glu 1590 1595 1600 1605 att tct cgg aag aat tagtaacgga gagctgacgg aag 4953 Ile Ser Arg Lys Asn                 1610 <210> 56 <211> 1610 <212> PRT <213> Corynebacterium glutamicum <400> 56 Met Glu Gln Ser Gln Ser Ser Asp Gln Lys Met Thr Val Glu Gln Val   1 5 10 15 Arg Thr Trp Leu Arg Asp Trp Val Val Arg Thr Thr Gly Ile Pro Val              20 25 30 Glu Glu Val Thr Asp Asp Lys Ala Met Glu Thr Phe Gly Leu Ser Ser          35 40 45 Arg Asp Val Val Val Leu Ser Gly Glu Leu Glu Asn Leu Leu Asp Thr      50 55 60 Ser Leu Asp Ala Thr Ile Ala Tyr Glu Tyr Pro Thr Ile Arg Ser Leu  65 70 75 80 Ala Gln Arg Leu Val Glu Gly Glu Pro Arg Arg Ala His Thr Gln Arg                  85 90 95 Glu Leu Asn Phe Ser Ala Val Ser Asp Ser Pro Gly Ser His Asp Ile             100 105 110 Ala Val Val Gly Met Ala Ala Arg Tyr Pro Gly Ala Glu Ser Leu Glu         115 120 125 Asp Met Trp Lys Leu Leu Val Glu Gly Arg Asp Gly Ile Ser Asp Leu     130 135 140 Pro Ile Gly Arg Trp Ser Glu Tyr Ala Gly Asp Glu Val Met Ser Arg 145 150 155 160 Lys Met Glu Glu Phe Ser Thr Ile Gly Gly Tyr Leu Ser Asp Ile Ser                 165 170 175 Ser Phe Asp Ala Glu Phe Phe Gly Leu Ser Pro Leu Glu Ala Ala Asn             180 185 190 Met Asp Pro Gln Gln Arg Ile Leu Leu Glu Leu Thr Trp Glu Ala Leu         195 200 205 Glu Tyr Ala Arg Ile Ala Pro Asn Thr Leu Arg Gly Glu Ala Val Gly     210 215 220 Val Phe Ile Gly Ser Ser Asn Asn Asp Tyr Gly Met Met Ile Ala Ala 225 230 235 240 Asp Pro Ala Glu Ala His Pro Tyr Ala Leu Thr Gly Thr Ser Ser Ala                 245 250 255 Ile Val Ala Asn Arg Ile Asn Tyr Ala Phe Asp Phe Arg Gly Pro Ser             260 265 270 Val Asn Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Val His Gln         275 280 285 Ala Val Arg Ala Leu Arg Asn Gly Glu Ala Asp His Ala Ile Ala Gly     290 295 300 Gly Val Asn Ile Leu Ala Ser Pro Phe Val Thr Thr Ala Phe Ala Glu 305 310 315 320 Leu Gly Val Ile Ser Pro Thr Gly Lys Ile His Ala Phe Ser Asp Asp                 325 330 335 Ala Asp Gly Phe Val Arg Ser Asp Gly Ala Gly Val Val Val Leu Lys             340 345 350 Arg Val Asp Asp Ala Ile Arg Asp Gly Asp Lys Ile Ile Gly Val Ile         355 360 365 Lys Gly Ser Ala Val Asn Ser Asp Gly His Ser Asn Gly Leu Thr Ala     370 375 380 Pro Asn Pro Asp Ala Gln Val Asp Val Leu Gln Arg Ala Tyr Val Asp 385 390 395 400 Ala Gln Val Asp Pro Thr Thr Val Asp Tyr Val Glu Ala His Gly Thr                 405 410 415 Gly Thr Ile Leu Gly Asp Pro Ile Glu Ala Thr Ala Leu Gly Ala Val             420 425 430 Leu Gly Tyr Gly Arg Asp Ala Ser Thr Pro Thr Leu Leu Gly Ser Ala         435 440 445 Lys Ser Asn Phe Gly His Thr Glu Ser Ala Ala Gly Ile Ala Gly Val     450 455 460 Ile Lys Val Leu Leu Ala Leu Gln Asn Lys Thr Leu Pro Pro Thr Val 465 470 475 480 Asn Phe Ala Gly Pro Asn Arg Tyr Ile Asp Phe Asp Ala Glu Arg Leu                 485 490 495 Glu Val Val Glu Asp Pro Arg Glu Trp Pro Glu Tyr Asn Gly His Ala             500 505 510 Val Ala Gly Val Ser Ala Phe Gly Phe Gly Gly Thr Asn Ala His Val         515 520 525 Val Ile Ser Glu Tyr Asn Ala Glu Asp Tyr Glu Thr Arg Ala Pro Lys     530 535 540 Glu Ala Leu Leu Pro Asp Gln Gln Val Ala Leu Pro Val Ser Gly His 545 550 555 560 Leu Pro Ser Arg Arg Arg Gln Ala Ala Ala Asp Leu Ala Asp Phe Leu                 565 570 575 Glu Gly Arg Lys Asp Cys Asp Leu Thr Pro Val Ala Arg Ala Leu Ala             580 585 590 Gly Arg Asn His Gly Arg Ser Arg Ala Val Val Leu Ala Ser Thr Ile         595 600 605 Glu Glu Ala Val Lys Arg Leu Arg Gln Val Ala Glu Gly Lys Val Ser     610 615 620 Val Gly Ile Ser Ala Ala Asp Ser Pro Ala Ala Asn Gly Pro Val Phe 625 630 635 640 Val Tyr Ser Gly Phe Gly Ser Gln His Arg Leu Met Ile Lys Glu Leu                 645 650 655 Cys Ser Ile Ser Pro Gln Phe Arg Glu Arg Ile Glu Glu Leu Asp Glu             660 665 670 Met Val Lys Phe Glu Ser Gly Trp Ser Ile Met Lys Leu Val Leu Asp         675 680 685 Asp Glu Gln Thr Tyr Asp Thr Glu Thr Ala Gln Val Val Ile Thr Ala     690 695 700 Ile Gln Ile Ala Leu Thr Asp Leu Leu Ala Ser Phe Gly Val Lys Pro 705 710 715 720 Ala Ala Val Met Gly Met Ser Met Gly Glu Ile Ala Ala Ala Tyr Ala                 725 730 735 Ala Gly Gly Leu Ser Asp Arg Asp Thr Met Leu Ile Ala Ser His Arg             740 745 750 Ser Arg Leu Met Gly Glu Gly Glu Lys Ser Leu Ala Glu Asp Gln Leu         755 760 765 Gly Ala Met Ala Val Val Glu Phe Ala Ala Ala Asp Leu Asp Lys Phe     770 775 780 Ile Glu Glu Asn Pro Glu Tyr Lys Gly Ile Glu Pro Ala Val Tyr Ala 785 790 795 800 Gly Pro Gly Met Thr Thr Val Gly Gly Pro Arg Asp Ala Val Val Gln                 805 810 815 Phe Val Glu Lys Leu Glu Ser Glu Asp Lys Phe Ala Arg Leu Leu Asn             820 825 830 Val Lys Gly Ala Gly His Thr Ser Ala Val Glu Pro Leu Leu Gly Glu         835 840 845 Leu Ala Gly Glu Ile Ala Gly Ile Glu Pro Leu Pro Leu Gln Ile Pro     850 855 860 Leu Phe Ser Ser Val Asp Gln Gly Val Thr Tyr Pro Val Gly Ala Val 865 870 875 880 Val His Asp Ala Asp Tyr Met Leu Arg Cys Thr Arg Gln Ser Val Tyr                 885 890 895 Phe Gln Asp Ser Thr Glu Ala Ala Phe Ala Ala Gly His Asn Thr Leu             900 905 910 Val Glu Ile Ser Pro Asn Pro Val Ala Leu Met Gly Met Met Asn Thr         915 920 925 Ala Phe Thr Val Gly Lys Pro Asp Ala Gln Leu Leu Phe Ser Leu Lys     930 935 940 Arg Lys Val Pro Glu Ala Glu Ser Leu Arg Asp Leu Leu Ala Lys Leu 945 950 955 960 Tyr Val Asn Gly Ala Asn Val Asp Phe Ser Ala Leu Tyr Gly Glu Gly                 965 970 975 Glu Thr Ile Asp Pro Pro His Ile Thr Trp Lys His Gln Arg Phe Trp             980 985 990 Thr Ser Ala Arg Pro Ser Ser Gly Ala Ser Leu Asp Leu Pro Gly Phe         995 1000 1005 Arg Val Asn Leu Pro Asn Asn Thr Val Ala Phe Ser Thr Ala Ala Glu     1010 1015 1020 Leu Ala Pro Ser Ala Val Ala Ile Met Glu Ala Ala Ala Met Ala Val 1025 1030 1035 1040 Thr Pro Gly Ser Ser Val Asp Ala Val Asp Glu Arg Asp Met Leu Pro                 1045 1050 1055 Pro Ser Gly Glu Ile Thr Thr Ile Val Thr Arg Ser Leu Gly Gly Leu             1060 1065 1070 Ser Leu Ser Val Tyr Lys Ile Glu Gly Thr Thr Ser Thr Leu Val Ala         1075 1080 1085 Glu Gly Phe Ala Ala Asn Pro Gly Phe Ala Ala Ala Ser Ser Phe Asp     1090 1095 1100 Gly Pro Gly Tyr Asp Gly Phe Asn Thr Asp Tyr Ser Asp Gln Pro Asp 1105 1110 1115 1120 Pro Arg Ser Asp Leu Pro Leu Asp Ile Glu Ala Val Arg Trp Asp Pro                 1125 1130 1135 Ala Thr Glu Thr Val Glu Glu Arg Met Arg Ala Ile Val Ser Glu Ala             1140 1145 1150 Met Gly Tyr Asp Val Asp Asp Leu Pro Arg Glu Leu Pro Leu Ile Asp         1155 1160 1165 Leu Gly Leu Asp Ser Leu Met Gly Met Arg Ile Lys Asn Arg Ile Glu     1170 1175 1180 Asn Asp Phe Gln Ile Pro Pro Leu Gln Val Gln Ala Leu Arg Asp Ala 1185 1190 1195 1200 Ser Val Ala Asp Val Val Ile Met Val Glu Asn Met Val Ala Gly Arg                 1205 1210 1215 Ser Ser Glu Thr Leu Val Asp Ala Thr Pro Gln Val Pro Ala Glu Ala             1220 1225 1230 Ala Gly Glu Ala Gln Ala Ala Glu Ser Ser Ala Ser Gly Glu Asp Val         1235 1240 1245 Gln Gly Val Gly Val Ala Pro Arg Asp Ala Ser Glu Arg Met Val Phe     1250 1255 1260 Gly Thr Trp Ala Gly Leu Thr Gly Ala Ala Ala Ala Gly Val Thr Ser 1265 1270 1275 1280 Lys Leu Pro Gln Ile Asp Val Asp Thr Ala Thr Ala Ile Ala Glu Arg                 1285 1290 1295 Leu Thr Glu Arg Ser Gly Ile Glu Ile Ser Thr Glu Gln Val Leu Ala             1300 1305 1310 Ala Glu Thr Leu Glu Pro Leu Ser Asp Leu Val Arg Glu Gly Leu Glu         1315 1320 1325 Thr Glu Val Gln Gly Asn Ile Arg Val Leu Arg Gly Arg Ala Glu Gly     1330 1335 1340 Ser Thr Lys Pro Ala Val Phe Met Phe His Pro Ala Gly Gly Ser Ser 1345 1350 1355 1360 Val Val Tyr Gln Pro Leu Met Arg Arg Leu Pro Glu Asp Val Pro Val                 1365 1370 1375 Tyr Gly Val Glu Arg Leu Glu Gly Asp Leu Ala Asp Arg Ala Ala Ala             1380 1385 1390 Tyr Val Asp Asp Ile Lys Lys Tyr Ser Asp Gly Phe Pro Val Val Leu         1395 1400 1405 Gly Gly Trp Ser Phe Gly Gly Ala Val Ala Phe Glu Val Ala His Gln     1410 1415 1420 Leu Val Gly Ser Asp Val Glu Val Ala Thr Val Ala Leu Leu Asp Thr 1425 1430 1435 1440 Val Gln Pro Ser Asn Pro Ala Pro Asp Thr Ala Glu Glu Thr Arg Ala                 1445 1450 1455 Arg Trp Thr Arg Tyr Ala Asp Phe Ala Lys Lys Thr Tyr Gly Leu Asp             1460 1465 1470 Phe Glu Val Pro Phe Glu Ile Leu Asp Thr Ile Gly Glu Asp Gly Met         1475 1480 1485 Leu Ser Met Met Thr Asp Phe Leu Ala Asn Thr Asp Ala Ser Glu His     1490 1495 1500 Gly Leu Ser Ala Gly Val Leu Glu His Gln Arg Ala Ser Phe Val Asp 1505 1510 1515 1520 Asn Arg Ile Leu Ala Lys Leu Asn Phe Ala Asp Trp Ala Asn Val Glu                 1525 1530 1535 Ala Pro Val Ile Leu Phe Arg Ala Glu Arg Met His Asp Gly Ala Ile             1540 1545 1550 Glu Leu Glu Pro Asn Tyr Ala Lys Ile Asp Gln Asp Gly Gly Trp Ser         1555 1560 1565 Gly Ile Val Asn Asp Leu Glu Ile Val Gln Leu Asn Gly Asp His Leu     1570 1575 1580 Ala Val Val Asp Glu Pro Glu Ile Gly Thr Val Gly Ala His Leu Ser 1585 1590 1595 1600 Arg Arg Ile Asp Glu Ile Ser Arg Lys Asn                 1605 1610 <210> 57 <211> 930 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (907) <223> RXA02691 <400> 57 cttagggctt atctgttttc cagccttgct ttttactagg cgctcctgtc ccgcttcagt 60 caccaaaacc acacccctgg ttatgaccag atcggctaaa atg aac acc atg cct 115                                             Met Asn Thr Met Pro                                               1 5 gac caa ccg ctc aac cag gac gga ttc cct acc gca tcc aaa ggg gtg 163 Asp Gln Pro Leu Asn Gln Asp Gly Phe Pro Thr Ala Ser Lys Gly Val                  10 15 20 gaa ccc gac aac ctc ccc gac cgc gtt ctc gtg gac ggc ctt aaa cca 211 Glu Pro Asp Asn Leu Pro Asp Arg Val Leu Val Asp Gly Leu Lys Pro              25 30 35 aag cat cag cag ctt cgt gaa att ttg gag gaa atc tgc acc acc cag 259 Lys His Gln Gln Leu Arg Glu Ile Leu Glu Glu Ile Cys Thr Thr Gln          40 45 50 ctt cag cct ggg gac atg ctg cct ggt gag cgc atc ctg gaa gaa aag 307 Leu Gln Pro Gly Asp Met Leu Pro Gly Glu Arg Ile Leu Glu Glu Lys      55 60 65 tat ggc gtc agc cga att acg gtt cgt cgg gcg att ggt gat ctg gtc 355 Tyr Gly Val Ser Arg Ile Thr Val Arg Arg Ala Ile Gly Asp Leu Val  70 75 80 85 gcg tcc ggc agg ttg aag cga gct cgc ggc aaa ggt acc ttc gtg gcc 403 Ala Ser Gly Arg Leu Lys Arg Ala Arg Gly Lys Gly Thr Phe Val Ala                  90 95 100 cac tcg ccg ttg att tcc cgc ctg cat ttg gcc tcg ttt tcc gca gag 451 His Ser Pro Leu Ile Ser Arg Leu His Leu Ala Ser Phe Ser Ala Glu             105 110 115 atg gcc gcc cag aag cta tcg gct acc agc agg att ttg agt tct tcc 499 Met Ala Ala Gln Lys Leu Ser Ala Thr Ser Arg Ile Leu Ser Ser Ser         120 125 130 cgc ggt ccc gcc cca gat gat att gct gat ttc ttt ggt acc gat cgc 547 Arg Gly Pro Ala Pro Asp Asp Ile Ala Asp Phe Phe Gly Thr Asp Arg     135 140 145 gcg gcc cag cac atc acg ttg cgc cgc ctg cgc ttt gga aat ggt cga 595 Ala Ala Gln His Ile Thr Leu Arg Arg Leu Arg Phe Gly Asn Gly Arg 150 155 160 165 ccc tat gcc att gac aac ggt tgg tac aac tcc gaa ttc gca cct gac 643 Pro Tyr Ala Ile Asp Asn Gly Trp Tyr Asn Ser Glu Phe Ala Pro Asp                 170 175 180 ctg ctg gaa aat gat gtg tac aac tcc gtg tac tcc atc ctg gac cgc 691 Leu Leu Glu Asn Asp Val Tyr Asn Ser Val Tyr Ser Ile Leu Asp Arg             185 190 195 gtc tat ggc gtc ccc gtc acc cag gcc gag caa acg gtc acc gcc gta 739 Val Tyr Gly Val Pro Val Thr Gln Ala Glu Gln Thr Val Thr Ala Val         200 205 210 gca gcc gac gaa gac acc gca cgg ctt ctg gac gtc acc ccc ggc gcc 787 Ala Ala Asp Glu Asp Thr Ala Arg Leu Leu Asp Val Thr Pro Gly Ala     215 220 225 cca ctc ctt cgt atc ctt cga cag tca ctt tct ggc gat aag ccc gtg 835 Pro Leu Leu Arg Ile Leu Arg Gln Ser Leu Ser Gly Asp Lys Pro Val 230 235 240 245 gaa tgg tgc gtt tcc ttg tac cga acc gac cga tat tct tta aaa aca 883 Glu Trp Cys Val Ser Leu Tyr Arg Thr Asp Arg Tyr Ser Leu Lys Thr                 250 255 260 ttg gtt aca cgc tcc gaa gat ctc tgacgtgaac ccattttggt ggc 930 Leu Val Thr Arg Ser Glu Asp Leu             265 <210> 58 <211> 269 <212> PRT <213> Corynebacterium glutamicum <400> 58 Met Asn Thr Met Pro Asp Gln Pro Leu Asn Gln Asp Gly Phe Pro Thr   1 5 10 15 Ala Ser Lys Gly Val Glu Pro Asp Asn Leu Pro Asp Arg Val Leu Val              20 25 30 Asp Gly Leu Lys Pro Lys His Gln Gln Leu Arg Glu Ile Leu Glu Glu          35 40 45 Ile Cys Thr Thr Gln Leu Gln Pro Gly Asp Met Leu Pro Gly Glu Arg      50 55 60 Ile Leu Glu Glu Lys Tyr Gly Val Ser Arg Ile Thr Val Arg Arg Ala  65 70 75 80 Ile Gly Asp Leu Val Ala Ser Gly Arg Leu Lys Arg Ala Arg Gly Lys                  85 90 95 Gly Thr Phe Val Ala His Ser Pro Leu Ile Ser Arg Leu His Leu Ala             100 105 110 Ser Phe Ser Ala Glu Met Ala Ala Gln Lys Leu Ser Ala Thr Ser Arg         115 120 125 Ile Leu Ser Ser Ser Arg Gly Pro Ala Pro Asp Asp Ile Ala Asp Phe     130 135 140 Phe Gly Thr Asp Arg Ala Ala Gln His Ile Thr Leu Arg Arg Leu Arg 145 150 155 160 Phe Gly Asn Gly Arg Pro Tyr Ala Ile Asp Asn Gly Trp Tyr Asn Ser                 165 170 175 Glu Phe Ala Pro Asp Leu Leu Glu Asn Asp Val Tyr Asn Ser Val Tyr             180 185 190 Ser Ile Leu Asp Arg Val Tyr Gly Val Pro Val Thr Gln Ala Glu Gln         195 200 205 Thr Val Thr Ala Val Ala Ala Asp Glu Asp Thr Ala Arg Leu Leu Asp     210 215 220 Val Thr Pro Gly Ala Pro Leu Leu Arg Ile Leu Arg Gln Ser Leu Ser 225 230 235 240 Gly Asp Lys Pro Val Glu Trp Cys Val Ser Leu Tyr Arg Thr Asp Arg                 245 250 255 Tyr Ser Leu Lys Thr Leu Val Thr Arg Ser Glu Asp Leu             260 265 <210> 59 <211> 1968 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1945) <223> RXA00880 <400> 59 tccatgtggt taaagatatg cctaaagatc tgaccaaaaa cgtgactaaa gacgtgacga 60 cacaagtaca gccaaattaa aggaaaggtt gaatttgacc atg act tca cct aat 115                                             Met thr ser pro asn                                               1 5 acc ctg cag gaa tac act gaa cct gcc aag tac acc atc gga gaa tct 163 Thr Leu Gln Glu Tyr Thr Glu Pro Ala Lys Tyr Thr Ile Gly Glu Ser                  10 15 20 gaa acc tgc ctg acc gcc ctt cta gat cag att aag act cga cct tac 211 Glu Thr Cys Leu Thr Ala Leu Leu Asp Gln Ile Lys Thr Arg Pro Tyr              25 30 35 gga gtt ttg ttc agc aag cct gcc aac tat gag tgg gtg aat gta act 259 Gly Val Leu Phe Ser Lys Pro Ala Asn Tyr Glu Trp Val Asn Val Thr          40 45 50 gcc aaa gaa ttt cag gac gag gtt ttt gcg gtt gca aaa gga att att 307 Ala Lys Glu Phe Gln Asp Glu Val Phe Ala Val Ala Lys Gly Ile Ile      55 60 65 tca gtc ggc gta gag cag gga gac cgt gtc gcg ctg ctg tcc aat act 355 Ser Val Gly Val Glu Gln Gly Asp Arg Val Ala Leu Leu Ser Asn Thr  70 75 80 85 cgc tat gag tgg gct gtg ctt gat ttc gct atc tgg gcc gct ggc gca 403 Arg Tyr Glu Trp Ala Val Leu Asp Phe Ala Ile Trp Ala Ala Gly Ala                  90 95 100 gtg agc gtg cct atc tac agc tcc tct tca ctg tcc caa att gag tgg 451 Val Ser Val Pro Ile Tyr Ser Ser Ser Ser Leu Ser Gln Ile Glu Trp             105 110 115 atc att gag gat tcc ggc gct gtt ttg gcc att acc gaa acc cct gat 499 Ile Ile Glu Asp Ser Gly Ala Val Leu Ala Ile Thr Glu Thr Pro Asp         120 125 130 cat acc gac ttg atg aag aac ctg gtc atc ggt gaa gac gga act cca 547 His Thr Asp Leu Met Lys Asn Leu Val Ile Gly Glu Asp Gly Thr Pro     135 140 145 gcg att aag ggt tca cct tcc aag ctg cgc cgc att cta gag atc aac 595 Ala Ile Lys Gly Ser Pro Ser Lys Leu Arg Arg Ile Leu Glu Ile Asn 150 155 160 165 tct tcg gcg ttg gag acc ttg aag ttt gag ggc cgc gag ctt tct gat 643 Ser Ser Ala Leu Glu Thr Leu Lys Phe Glu Gly Arg Glu Leu Ser Asp                 170 175 180 gag ctg gtg tgg gaa cgc att cat gca acc aag gcc gct gac ctg gcg 691 Glu Leu Val Trp Glu Arg Ile His Ala Thr Lys Ala Ala Asp Leu Ala             185 190 195 tct ttg gtg tac acc tct ggc aca act ggt agg ccg aag ggc tgc gag 739 Ser Leu Val Tyr Thr Ser Gly Thr Thr Gly Arg Pro Lys Gly Cys Glu         200 205 210 ttg tcc cac tac cac tgg ttg gct gag gtc cga gcg ctg atc acc aat 787 Leu Ser His Tyr His Trp Leu Ala Glu Val Arg Ala Leu Ile Thr Asn     215 220 225 gac atc gga gcg atc gcg atg cca ggt tca agg ttg ctc acc ttc ctt 835 Asp Ile Gly Ala Ile Ala Met Pro Gly Ser Arg Leu Leu Thr Phe Leu 230 235 240 245 cct ttg gcg cac gtt ctt gct cgc gca gtg cac ttg gcc ttc gct gtc 883 Pro Leu Ala His Val Leu Ala Arg Ala Val His Leu Ala Phe Ala Val                 250 255 260 acc ggt gca acc cag tcc cac tgg tct gat ttc agc acc ctt act ttg 931 Thr Gly Ala Thr Gln Ser His Trp Ser Asp Phe Ser Thr Leu Thr Leu             265 270 275 gaa ctg cag cgt tcc cgc ccg aac ctg att ttg ggt gtt cca cgc gtg 979 Glu Leu Gln Arg Ser Arg Pro Asn Leu Ile Leu Gly Val Pro Arg Val         280 285 290 ttt gaa aag gtc cgc aac gcc gct gct gct aat gct gct gac ggt ggc 1027 Phe Glu Lys Val Arg Asn Ala Ala Ala Ala Asn Ala Ala Asp Gly Gly     295 300 305 gca atc aag cgc atc atg ttt gag cgt gcc gaa aag gcg gcc att gaa 1075 Ala Ile Lys Arg Ile Met Phe Glu Arg Ala Glu Lys Ala Ala Ile Glu 310 315 320 325 tac tcc atg gct ctt gat act gca gaa ggc cca agc aag tcc cag gtt 1123 Tyr Ser Met Ala Leu Asp Thr Ala Glu Gly Pro Ser Lys Ser Gln Val                 330 335 340 atg gca cat aaa gcg ttt gac aag ctg gtg tac tcc aag atc cgt gca 1171 Met Ala His Lys Ala Phe Asp Lys Leu Val Tyr Ser Lys Ile Arg Ala             345 350 355 gct gtc ggt ggc gat gtg cag tac gcc atc acc ggt ggt tca gcg atg 1219 Ala Val Gly Gly Asp Val Gln Tyr Ala Ile Thr Gly Gly Ser Ala Met         360 365 370 ggg cag gag ctg ctg cac ttc ttc cgc ggt gtg ggc atg acc atc tac 1267 Gly Gln Glu Leu Leu His Phe Phe Arg Gly Val Gly Met Thr Ile Tyr     375 380 385 gaa ggt tat ggt ctg acg gaa tct gcg gct gct gca gcg gtg gac ttc 1315 Glu Gly Tyr Gly Leu Thr Glu Ser Ala Ala Ala Ala Ala Val Asp Phe 390 395 400 405 act gat caa aag atc ggc act gtg ggt aag ccg atg ggt ggc atg acc 1363 Thr Asp Gln Lys Ile Gly Thr Val Gly Lys Pro Met Gly Gly Met Thr                 410 415 420 atc aag atc aat gaa gat ggc gaa atc atg cta aaa ggc gag atg ttg 1411 Ile Lys Ile Asn Glu Asp Gly Glu Ile Met Leu Lys Gly Glu Met Leu             425 430 435 ttc cag gga tat tgg aac aac cca gaa gcc aca gca gaa gcc ctc cac 1459 Phe Gln Gly Tyr Trp Asn Asn Pro Glu Ala Thr Ala Glu Ala Leu His         440 445 450 gac ggt tgg ttc aac acc ggc gat ctg ggt gag ctg ttg gag tct gga 1507 Asp Gly Trp Phe Asn Thr Gly Asp Leu Gly Glu Leu Leu Glu Ser Gly     455 460 465 cac ctg gtg atc acc gga cgt aag aaa gat ctg atc gtg acc gcg ggc 1555 His Leu Val Ile Thr Gly Arg Lys Lys Asp Leu Ile Val Thr Ala Gly 470 475 480 485 ggc aag aac gtt tcc cca gga ccc atg gaa gac atc atc cgc gca cac 1603 Gly Lys Asn Val Ser Pro Gly Pro Met Glu Asp Ile Ile Arg Ala His                 490 495 500 cca ctg gtc agc cag gcc atg gtg gtg ggc gat ggt aaa cca ttc gtt 1651 Pro Leu Val Ser Gln Ala Met Val Val Gly Asp Gly Lys Pro Phe Val             505 510 515 ggc ctg ctg gtg acc ttg gat cca gat atg ttg aag cgg tgg aag ctg 1699 Gly Leu Leu Val Thr Leu Asp Pro Asp Met Leu Lys Arg Trp Lys Leu         520 525 530 aac cac aac att gcg gaa tcc cgc acg gtt tct gag att gct act gat 1747 Asn His Asn Ile Ala Glu Ser Arg Thr Val Ser Glu Ile Ala Thr Asp     535 540 545 cct gca ctg cgt gcg gaa atc cag gat gca gtc aac aac gct aat gcc 1795 Pro Ala Leu Arg Ala Glu Ile Gln Asp Ala Val Asn Asn Ala Asn Ala 550 555 560 565 acg gtg tct cat tca gag gcg atc aag cgg ttc tac atc ctt gat cgc 1843 Thr Val Ser His Ser Glu Ala Ile Lys Arg Phe Tyr Ile Leu Asp Arg                 570 575 580 gac ctg acc gag gaa gcc gac gag ctg acc cca acg ctg aag gtc aag 1891 Asp Leu Thr Glu Glu Ala Asp Glu Leu Thr Pro Thr Leu Lys Val Lys             585 590 595 cgc aac gtt gtt gtt cgc cgt tac gca gac gcc atc gac cac atc tac 1939 Arg Asn Val Val Val Arg Arg Tyr Ala Asp Ala Ile Asp His Ile Tyr         600 605 610 aac cga tgagtaacac agagacccaa ttt 1968 Asn arg     615 <210> 60 <211> 615 <212> PRT <213> Corynebacterium glutamicum <400> 60 Met Thr Ser Pro Asn Thr Leu Gln Glu Tyr Thr Glu Pro Ala Lys Tyr   1 5 10 15 Thr Ile Gly Glu Ser Glu Thr Cys Leu Thr Ala Leu Leu Asp Gln Ile              20 25 30 Lys Thr Arg Pro Tyr Gly Val Leu Phe Ser Lys Pro Ala Asn Tyr Glu          35 40 45 Trp Val Asn Val Thr Ala Lys Glu Phe Gln Asp Glu Val Phe Ala Val      50 55 60 Ala Lys Gly Ile Ile Ser Val Gly Val Glu Gln Gly Asp Arg Val Ala  65 70 75 80 Leu Leu Ser Asn Thr Arg Tyr Glu Trp Ala Val Leu Asp Phe Ala Ile                  85 90 95 Trp Ala Ala Gly Ala Val Ser Val Pro Ile Tyr Ser Ser Ser Ser Leu             100 105 110 Ser Gln Ile Glu Trp Ile Ile Glu Asp Ser Gly Ala Val Leu Ala Ile         115 120 125 Thr Glu Thr Pro Asp His Thr Asp Leu Met Lys Asn Leu Val Ile Gly     130 135 140 Glu Asp Gly Thr Pro Ala Ile Lys Gly Ser Pro Ser Lys Leu Arg Arg 145 150 155 160 Ile Leu Glu Ile Asn Ser Ser Ala Leu Glu Thr Leu Lys Phe Glu Gly                 165 170 175 Arg Glu Leu Ser Asp Glu Leu Val Trp Glu Arg Ile His Ala Thr Lys             180 185 190 Ala Ala Asp Leu Ala Ser Leu Val Tyr Thr Ser Gly Thr Thr Gly Arg         195 200 205 Pro Lys Gly Cys Glu Leu Ser His Tyr His Trp Leu Ala Glu Val Arg     210 215 220 Ala Leu Ile Thr Asn Asp Ile Gly Ala Ile Ala Met Pro Gly Ser Arg 225 230 235 240 Leu Leu Thr Phe Leu Pro Leu Ala His Val Leu Ala Arg Ala Val His                 245 250 255 Leu Ala Phe Ala Val Thr Gly Ala Thr Gln Ser His Trp Ser Asp Phe             260 265 270 Ser Thr Leu Thr Leu Glu Leu Gln Arg Ser Arg Pro Asn Leu Ile Leu         275 280 285 Gly Val Pro Arg Val Phe Glu Lys Val Arg Asn Ala Ala Ala Ala Asn     290 295 300 Ala Ala Asp Gly Gly Ala Ile Lys Arg Ile Met Phe Glu Arg Ala Glu 305 310 315 320 Lys Ala Ala Ile Glu Tyr Ser Met Ala Leu Asp Thr Ala Glu Gly Pro                 325 330 335 Ser Lys Ser Gln Val Met Ala His Lys Ala Phe Asp Lys Leu Val Tyr             340 345 350 Ser Lys Ile Arg Ala Ala Val Gly Gly Asp Val Gln Tyr Ala Ile Thr         355 360 365 Gly Gly Ser Ala Met Gly Gln Glu Leu Leu His Phe Phe Arg Gly Val     370 375 380 Gly Met Thr Ile Tyr Glu Gly Tyr Gly Leu Thr Glu Ser Ala Ala Ala 385 390 395 400 Ala Ala Val Asp Phe Thr Asp Gln Lys Ile Gly Thr Val Gly Lys Pro                 405 410 415 Met Gly Gly Met Thr Ile Lys Ile Asn Glu Asp Gly Glu Ile Met Leu             420 425 430 Lys Gly Glu Met Leu Phe Gln Gly Tyr Trp Asn Asn Pro Glu Ala Thr         435 440 445 Ala Glu Ala Leu His Asp Gly Trp Phe Asn Thr Gly Asp Leu Gly Glu     450 455 460 Leu Leu Glu Ser Gly His Leu Val Ile Thr Gly Arg Lys Lys Asp Leu 465 470 475 480 Ile Val Thr Ala Gly Gly Lys Asn Val Ser Pro Gly Pro Met Glu Asp                 485 490 495 Ile Ile Arg Ala His Pro Leu Val Ser Gln Ala Met Val Val Gly Asp             500 505 510 Gly Lys Pro Phe Val Gly Leu Leu Val Thr Leu Asp Pro Asp Met Leu         515 520 525 Lys Arg Trp Lys Leu Asn His Asn Ile Ala Glu Ser Arg Thr Val Ser     530 535 540 Glu Ile Ala Thr Asp Pro Ala Leu Arg Ala Glu Ile Gln Asp Ala Val 545 550 555 560 Asn Asn Ala Asn Ala Thr Val Ser His Ser Glu Ala Ile Lys Arg Phe                 565 570 575 Tyr Ile Leu Asp Arg Asp Leu Thr Glu Glu Ala Asp Glu Leu Thr Pro             580 585 590 Thr Leu Lys Val Lys Arg Asn Val Val Val Arg Arg Tyr Ala Asp Ala         595 600 605 Ile Asp His Ile Tyr Asn Arg     610 615 <210> 61 <211> 1047 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (1024) <223> RXA01060 <400> 61 ttccatttac acatctgttc gactcgcgcc cgaatgatgt cgcatcaaca tgagaagcta 60 cttccatact tttactgatt gataagaatg gacaaagaca atg aac cgc aca ctc 115                                             Met Asn Arg Thr Leu                                               1 5 cga aca ctt ggc tgg ctt gct gcc gta att caa gaa gat ccg gag ccc 163 Arg Thr Leu Gly Trp Leu Ala Ala Val Ile Gln Glu Asp Pro Glu Pro                  10 15 20 tgg ttc acc act gat ccc gac acc gat tat gtc cct tat gta aat agt 211 Trp Phe Thr Thr Asp Pro Asp Thr Asp Tyr Val Pro Tyr Val Asn Ser              25 30 35 ttc tca ttt gaa tcc ctt tcc ctc gtt cca gat gct ctg atg ctg ctc 259 Phe Ser Phe Glu Ser Leu Ser Leu Val Pro Asp Ala Leu Met Leu Leu          40 45 50 aaa cgt tct ctt cac ctt gcg atg gag caa cag gac ctc cca gtg aag 307 Lys Arg Ser Leu His Leu Ala Met Glu Gln Gln Asp Leu Pro Val Lys      55 60 65 gat cta caa gaa gca ctg agg cac gta cta gtt ttc aaa ttc cac ttc 355 Asp Leu Gln Glu Ala Leu Arg His Val Leu Val Phe Lys Phe His Phe  70 75 80 85 agg gaa gaa tgg gag ctg gaa tta gca tgg gac tcc gag cgg acc aag 403 Arg Glu Glu Trp Glu Leu Glu Leu Ala Trp Asp Ser Glu Arg Thr Lys                  90 95 100 tct gcg gtg aga att att gag agc aca aaa gaa tct ctt gcc gat caa 451 Ser Ala Val Arg Ile Ile Glu Ser Thr Lys Glu Ser Leu Ala Asp Gln             105 110 115 tac aga gat tac aaa tac gca ttc ttg cct gag cta att ttc cag gaa 499 Tyr Arg Asp Tyr Lys Tyr Ala Phe Leu Pro Glu Leu Ile Phe Gln Glu         120 125 130 tca cgc ggg atc ttt gac ttt gag ctg gag gga tac acc ctc aaa gta 547 Ser Arg Gly Ile Phe Asp Phe Glu Leu Glu Gly Tyr Thr Leu Lys Val     135 140 145 gga caa agc acg ctt tcc att cct tgg gac atg atc gcc aat ggt tat 595 Gly Gln Ser Thr Leu Ser Ile Pro Trp Asp Met Ile Ala Asn Gly Tyr 150 155 160 165 gtc cct gca agt ctt cgg aat ttt gga gaa tta atg gac cgt gac acc 643 Val Pro Ala Ser Leu Arg Asn Phe Gly Glu Leu Met Asp Arg Asp Thr                 170 175 180 gga gat ctt gat gca gat ccc att ctg aga cct cga gaa ctc aaa ttt 691 Gly Asp Leu Asp Ala Asp Pro Ile Leu Arg Pro Arg Glu Leu Lys Phe             185 190 195 gag atc cat aat tgt cca gat ctt aat cct tgg ata atg cgg gaa act 739 Glu Ile His Asn Cys Pro Asp Leu Asn Pro Trp Ile Met Arg Glu Thr         200 205 210 ttt gat ttc atg atg gaa atc gca act gaa aca gga tgg ttc cat gct 787 Phe Asp Phe Met Met Glu Ile Ala Thr Glu Thr Gly Trp Phe His Ala     215 220 225 ctc aac ccc gca tat aat tcc gtc tac acc tac gat ctt att tct cgc 835 Leu Asn Pro Ala Tyr Asn Ser Val Tyr Thr Tyr Asp Leu Ile Ser Arg 230 235 240 245 atg cca gat ttc ctt gtt gaa ggg agc ttt cgt ccg cat tca gtg aaa 883 Met Pro Asp Phe Leu Val Glu Gly Ser Phe Arg Pro His Ser Val Lys                 250 255 260 cga tct tgg gaa aaa att caa aag ata gct aaa gct gtt gag tct tat 931 Arg Ser Trp Glu Lys Ile Gln Lys Ile Ala Lys Ala Val Glu Ser Tyr             265 270 275 gca tct cac gat tac tgc atg tca acg ctg aca cat gac tac agg gca 979 Ala Ser His Asp Tyr Cys Met Ser Thr Leu Thr His Asp Tyr Arg Ala         280 285 290 atc gag tta tcc ctg acg cct aca aaa act gag gaa cca agc aca 1024 Ile Glu Leu Ser Leu Thr Pro Thr Lys Thr Glu Glu Pro Ser Thr     295 300 305 taagaaaacc tcgcctgccc act 1047 <210> 62 <211> 308 <212> PRT <213> Corynebacterium glutamicum <400> 62 Met Asn Arg Thr Leu Arg Thr Leu Gly Trp Leu Ala Ala Val Ile Gln   1 5 10 15 Glu Asp Pro Glu Pro Trp Phe Thr Thr Asp Pro Asp Thr Asp Tyr Val              20 25 30 Pro Tyr Val Asn Ser Phe Ser Phe Glu Ser Leu Ser Leu Val Pro Asp          35 40 45 Ala Leu Met Leu Leu Lys Arg Ser Leu His Leu Ala Met Glu Gln Gln      50 55 60 Asp Leu Pro Val Lys Asp Leu Gln Glu Ala Leu Arg His Val Leu Val  65 70 75 80 Phe Lys Phe His Phe Arg Glu Glu Trp Glu Leu Glu Leu Ala Trp Asp                  85 90 95 Ser Glu Arg Thr Lys Ser Ala Val Arg Ile Ile Glu Ser Thr Lys Glu             100 105 110 Ser Leu Ala Asp Gln Tyr Arg Asp Tyr Lys Tyr Ala Phe Leu Pro Glu         115 120 125 Leu Ile Phe Gln Glu Ser Arg Gly Ile Phe Asp Phe Glu Leu Glu Gly     130 135 140 Tyr Thr Leu Lys Val Gly Gln Ser Thr Leu Ser Ile Pro Trp Asp Met 145 150 155 160 Ile Ala Asn Gly Tyr Val Pro Ala Ser Leu Arg Asn Phe Gly Glu Leu                 165 170 175 Met Asp Arg Asp Thr Gly Asp Leu Asp Ala Asp Pro Ile Leu Arg Pro             180 185 190 Arg Glu Leu Lys Phe Glu Ile His Asn Cys Pro Asp Leu Asn Pro Trp         195 200 205 Ile Met Arg Glu Thr Phe Asp Phe Met Met Glu Ile Ala Thr Glu Thr     210 215 220 Gly Trp Phe His Ala Leu Asn Pro Ala Tyr Asn Ser Val Tyr Thr Tyr 225 230 235 240 Asp Leu Ile Ser Arg Met Pro Asp Phe Leu Val Glu Gly Ser Phe Arg                 245 250 255 Pro His Ser Val Lys Arg Ser Trp Glu Lys Ile Gln Lys Ile Ala Lys             260 265 270 Ala Val Glu Ser Tyr Ala Ser His Asp Tyr Cys Met Ser Thr Leu Thr         275 280 285 His Asp Tyr Arg Ala Ile Glu Leu Ser Leu Thr Pro Thr Lys Thr Glu     290 295 300 Glu Pro Ser Thr 305 <210> 63 <211> 1848 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) .. (1825) <223> RXN01722 <400> 63 ctcattcccc tcgctaaaag ctgcataaag tttcgacgtt ttcaaagttg attgcttgca 60 ctgtcgttgc gtgtcgcatg ccccggctat tgttgattgc atg ctc agc acg atg 115                                             Met Leu Ser Thr Met                                               1 5 cag gac gtc cca ctg tca tta acc aga atc ctc gag tac ggg tcc act 163 Gln Asp Val Pro Leu Ser Leu Thr Arg Ile Leu Glu Tyr Gly Ser Thr                  10 15 20 gtt cac ggt gat act ttg atc acc acg tgg ggc ggt gcc gat ggc att 211 Val His Gly Asp Thr Leu Ile Thr Thr Trp Gly Gly Ala Asp Gly Ile              25 30 35 gaa caa gca cag caa act ttt agt gct gtg ggg gct aga gct gcg gct 259 Glu Gln Ala Gln Gln Thr Phe Ser Ala Val Gly Ala Arg Ala Ala Ala          40 45 50 ttg gct cat gcg ctg cat gat tct tta ggt att act ggg gat cag cga 307 Leu Ala His Ala Leu His Asp Ser Leu Gly Ile Thr Gly Asp Gln Arg      55 60 65 gtg gcg tcg atg ctc tat aac tgc gcg gaa cac atg gaa act atg ttt 355 Val Ala Ser Met Leu Tyr Asn Cys Ala Glu His Met Glu Thr Met Phe  70 75 80 85 gca gtc gca tgc atg ggt gcc gtg ttt aat ccg ctg aac aag cag ttg 403 Ala Val Ala Cys Met Gly Ala Val Phe Asn Pro Leu Asn Lys Gln Leu                  90 95 100 atg aat gat cag att gtg ttc att ctc aat cac tct gaa gct gaa gtg 451 Met Asn Asp Gln Ile Val Phe Ile Leu Asn His Ser Glu Ala Glu Val             105 110 115 gtt atc gct gat ccg cgc atg gct gaa caa ttg ggt gag atc tta aaa 499 Val Ile Ala Asp Pro Arg Met Ala Glu Gln Leu Gly Glu Ile Leu Lys         120 125 130 gaa aca cca aaa gtt cgt gcc gtg gtg ttt att gga ccg aat gat ttc 547 Glu Thr Pro Lys Val Arg Ala Val Val Phe Ile Gly Pro Asn Asp Phe     135 140 145 tct agc gcg gcg gcc cac atg ccg gag gga atg aag ctg tat tcc tat 595 Ser Ser Ala Ala Ala His Met Pro Glu Gly Met Lys Leu Tyr Ser Tyr 150 155 160 165 gaa gcg ctc ctt gac ggc cgt tcc act gtt tac aac tgg ccc gag cag 643 Glu Ala Leu Leu Asp Gly Arg Ser Thr Val Tyr Asn Trp Pro Glu Gln                 170 175 180 gat gaa cgc act gct gct gca att tgc tat tcc acc ggt aca tcg gga 691 Asp Glu Arg Thr Ala Ala Ala Ile Cys Tyr Ser Thr Gly Thr Ser Gly             185 190 195 ccg ccg aag ggt gtg gtg tat tcc cac cgc tcg ctt tat tta cag tcg 739 Pro Pro Lys Gly Val Val Tyr Ser His Arg Ser Leu Tyr Leu Gln Ser         200 205 210 ttg agc ttg cgc acc acg gat tcc ctc gca gtg gaa cac ggc gaa acg 787 Leu Ser Leu Arg Thr Thr Asp Ser Leu Ala Val Glu His Gly Glu Thr     215 220 225 ttc ctg tgc tgt gtg ccg att tac cac gtc ctc agc tgg ggc gtg ccg 835 Phe Leu Cys Cys Val Pro Ile Tyr His Val Leu Ser Trp Gly Val Pro 230 235 240 245 atc gca gcg ttt atg tcc ggc act ccc ctg gtg ctt cct gga ccg gat 883 Ile Ala Ala Phe Met Ser Gly Thr Pro Leu Val Leu Pro Gly Pro Asp                 250 255 260 ctt tct gcg ccg aca ttg gca aag atc att tcc acc acg ctg cct cgc 931 Leu Ser Ala Pro Thr Leu Ala Lys Ile Ile Ser Thr Thr Leu Pro Arg             265 270 275 gtg gcg cat ggc gtg cct act ctc tgg att cag ctg atg gtt cac tac 979 Val Ala His Gly Val Pro Thr Leu Trp Ile Gln Leu Met Val His Tyr         280 285 290 ctg aaa aat ccc cca gag cgt atg tct ctg cgt gag cta tac gtg ggc 1027 Leu Lys Asn Pro Pro Glu Arg Met Ser Leu Arg Glu Leu Tyr Val Gly     295 300 305 ggt tct gcg gtg cct cca atc gtg atc acc atg tgg gag cag cgc tat 1075 Gly Ser Ala Val Pro Pro Ile Val Ile Thr Met Trp Glu Gln Arg Tyr 310 315 320 325 ggc gtg gat gtt gtc cac gtg tgg ggt atg acg gaa acc tcc acc gtg 1123 Gly Val Asp Val Val His Val Trp Gly Met Thr Glu Thr Ser Thr Val                 330 335 340 ggt act gtg tct cgc cca cca tca ggt gtt tct ggt gaa agc cgg tgg 1171 Gly Thr Val Ser Arg Pro Pro Ser Gly Val Ser Gly Glu Ser Arg Trp             345 350 355 aat tat cga gtc tcc cag ggc cga ttc ccc gcc tcc ctg cag tac cgc 1219 Asn Tyr Arg Val Ser Gln Gly Arg Phe Pro Ala Ser Leu Gln Tyr Arg         360 365 370 att gtc aac gac ggc cag gtc atg gcg tcc acc gac cgc aac gag ggc 1267 Ile Val Asn Asp Gly Gln Val Met Ala Ser Thr Asp Arg Asn Glu Gly     375 380 385 gag att cag gtc cgc ggt ccg tgg gtg act gca agt tac ttc cac ccc 1315 Glu Ile Gln Val Arg Gly Pro Trp Val Thr Ala Ser Tyr Phe His Pro 390 395 400 405 gat gtg gaa aaa gaa ggt ggc acc gcc tca aca ttc cgc gac cat gac 1363 Asp Val Glu Lys Glu Gly Gly Thr Ala Ser Thr Phe Arg Asp His Asp                 410 415 420 gtt gaa gag gaa aac gat gag ctc ttc acc gcc gac ggc tgg ctg cgc 1411 Val Glu Glu Glu Asn Asp Glu Leu Phe Thr Ala Asp Gly Trp Leu Arg             425 430 435 acc ggg gac gtt gga tct gtc acc agc gat gga ttc ctc acc atc caa 1459 Thr Gly Asp Val Gly Ser Val Thr Ser Asp Gly Phe Leu Thr Ile Gln         440 445 450 gac cgc gcc cgc gat gtc atc cgt tct ggc ggc gag tgg att tac tcc 1507 Asp Arg Ala Arg Asp Val Ile Arg Ser Gly Gly Glu Trp Ile Tyr Ser     455 460 465 gct cag ctg gaa aac ctc atc gtg gct acg gaa gag gtt gtc gaa tgc 1555 Ala Gln Leu Glu Asn Leu Ile Val Ala Thr Glu Glu Val Val Glu Cys 470 475 480 485 gcc gtc att ggc ttc ccc gat gac aag tgg gtg gaa cgt ccc ctc gca 1603 Ala Val Ile Gly Phe Pro Asp Asp Lys Trp Val Glu Arg Pro Leu Ala                 490 495 500 gtc acc atg ctc tac ccc ggc att gaa cgc acc cgg gaa acc gcc gag 1651 Val Thr Met Leu Tyr Pro Gly Ile Glu Arg Thr Arg Glu Thr Ala Glu             505 510 515 cgc ctc cgc gat caa ctt cgc gac cgc cta ccc aac tgg atg ctg cca 1699 Arg Leu Arg Asp Gln Leu Arg Asp Arg Leu Pro Asn Trp Met Leu Pro         520 525 530 gaa tat tgg aca ttt gtt gat gag gtg gat aaa acc tcc gtc ggt aaa 1747 Glu Tyr Trp Thr Phe Val Asp Glu Val Asp Lys Thr Ser Val Gly Lys     535 540 545 tat gac aag aag gac ctc cgc aac cac ctg cgc aac ggc gat ttc gaa 1795 Tyr Asp Lys Lys Asp Leu Arg Asn His Leu Arg Asn Gly Asp Phe Glu 550 555 560 565 gta att aag ctt aaa ggg cca ggt gaa aaa taacttccct atttattccg 1845 Val Ile Lys Leu Lys Gly Pro Gly Glu Lys                 570 575 gct 1848 <210> 64 <211> 575 <212> PRT <213> Corynebacterium glutamicum <400> 64 Met Leu Ser Thr Met Gln Asp Val Pro Leu Ser Leu Thr Arg Ile Leu   1 5 10 15 Glu Tyr Gly Ser Thr Val His Gly Asp Thr Leu Ile Thr Thr Trp Gly              20 25 30 Gly Ala Asp Gly Ile Glu Gln Ala Gln Gln Thr Phe Ser Ala Val Gly          35 40 45 Ala Arg Ala Ala Ala Leu Ala His Ala Leu His Asp Ser Leu Gly Ile      50 55 60 Thr Gly Asp Gln Arg Val Ala Ser Met Leu Tyr Asn Cys Ala Glu His  65 70 75 80 Met Glu Thr Met Phe Ala Val Ala Cys Met Gly Ala Val Phe Asn Pro                  85 90 95 Leu Asn Lys Gln Leu Met Asn Asp Gln Ile Val Phe Ile Leu Asn His             100 105 110 Ser Glu Ala Glu Val Val Ile Ala Asp Pro Arg Met Ala Glu Gln Leu         115 120 125 Gly Glu Ile Leu Lys Glu Thr Pro Lys Val Arg Ala Val Val Phe Ile     130 135 140 Gly Pro Asn Asp Phe Ser Ser Ala Ala Ala His Met Pro Glu Gly Met 145 150 155 160 Lys Leu Tyr Ser Tyr Glu Ala Leu Leu Asp Gly Arg Ser Thr Val Tyr                 165 170 175 Asn Trp Pro Glu Gln Asp Glu Arg Thr Ala Ala Ala Ile Cys Tyr Ser             180 185 190 Thr Gly Thr Ser Gly Pro Pro Lys Gly Val Val Tyr Ser His Arg Ser         195 200 205 Leu Tyr Leu Gln Ser Leu Ser Leu Arg Thr Thr Asp Ser Leu Ala Val     210 215 220 Glu His Gly Glu Thr Phe Leu Cys Cys Val Pro Ile Tyr His Val Leu 225 230 235 240 Ser Trp Gly Val Pro Ile Ala Ala Phe Met Ser Gly Thr Pro Leu Val                 245 250 255 Leu Pro Gly Pro Asp Leu Ser Ala Pro Thr Leu Ala Lys Ile Ile Ser             260 265 270 Thr Thr Leu Pro Arg Val Ala His Gly Val Pro Thr Leu Trp Ile Gln         275 280 285 Leu Met Val His Tyr Leu Lys Asn Pro Pro Glu Arg Met Ser Leu Arg     290 295 300 Glu Leu Tyr Val Gly Gly Ser Ala Val Pro Pro Ile Val Ile Thr Met 305 310 315 320 Trp Glu Gln Arg Tyr Gly Val Asp Val Val His Val Trp Gly Met Thr                 325 330 335 Glu Thr Ser Thr Val Gly Thr Val Ser Arg Pro Pro Ser Gly Val Ser             340 345 350 Gly Glu Ser Arg Trp Asn Tyr Arg Val Ser Gln Gly Arg Phe Pro Ala         355 360 365 Ser Leu Gln Tyr Arg Ile Val Asn Asp Gly Gln Val Met Ala Ser Thr     370 375 380 Asp Arg Asn Glu Gly Glu Ile Gln Val Arg Gly Pro Trp Val Thr Ala 385 390 395 400 Ser Tyr Phe His Pro Asp Val Glu Lys Glu Gly Gly Thr Ala Ser Thr                 405 410 415 Phe Arg Asp His Asp Val Glu Glu Glu Asn Asp Glu Leu Phe Thr Ala             420 425 430 Asp Gly Trp Leu Arg Thr Gly Asp Val Gly Ser Val Thr Ser Asp Gly         435 440 445 Phe Leu Thr Ile Gln Asp Arg Ala Arg Asp Val Ile Arg Ser Gly Gly     450 455 460 Glu Trp Ile Tyr Ser Ala Gln Leu Glu Asn Leu Ile Val Ala Thr Glu 465 470 475 480 Glu Val Val Glu Cys Ala Val Ile Gly Phe Pro Asp Asp Lys Trp Val                 485 490 495 Glu Arg Pro Leu Ala Val Thr Met Leu Tyr Pro Gly Ile Glu Arg Thr             500 505 510 Arg Glu Thr Ala Glu Arg Leu Arg Asp Gln Leu Arg Asp Arg Leu Pro         515 520 525 Asn Trp Met Leu Pro Glu Tyr Trp Thr Phe Val Asp Glu Val Asp Lys     530 535 540 Thr Ser Val Gly Lys Tyr Asp Lys Lys Asp Leu Arg Asn His Leu Arg 545 550 555 560 Asn Gly Asp Phe Glu Val Ile Lys Leu Lys Gly Pro Gly Glu Lys                 565 570 575 <210> 65 <211> 1848 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) .. (1825) <223> FRXA01722 <220> <221> VARIANT <222> 479 X223 = Thr <220> <221> VARIANT <222> 574 <223> Xaa = Glu <400> 65 ctcattcccc tcgctaaaag ctgcataaag tttcgacgtt ttcaaagttg attgcttgca 60 ctgtcgttgc gtgtcgcatg ccccggctat tgttgattgc atg ctc agc acg atg 115                                             Met Leu Ser Thr Met                                               1 5 cag gac gtc cca ctg tca tta acc aga atc ctc gag tac ggg tcc act 163 Gln Asp Val Pro Leu Ser Leu Thr Arg Ile Leu Glu Tyr Gly Ser Thr                  10 15 20 gtt cac ggt gat act ttg atc acc acg tgg ggc ggt gcc gat ggc att 211 Val His Gly Asp Thr Leu Ile Thr Thr Trp Gly Gly Ala Asp Gly Ile              25 30 35 gaa caa gca cag caa act ttt agt gct gtg ggg gct aga gct gcg gct 259 Glu Gln Ala Gln Gln Thr Phe Ser Ala Val Gly Ala Arg Ala Ala Ala          40 45 50 ttg gct cat gcg ctg cat gat tct tta ggt att act ggg gat cag cga 307 Leu Ala His Ala Leu His Asp Ser Leu Gly Ile Thr Gly Asp Gln Arg      55 60 65 gtg gcg tcg atg ctc tat aac tgc gcg gaa cac atg gaa act atg ttt 355 Val Ala Ser Met Leu Tyr Asn Cys Ala Glu His Met Glu Thr Met Phe  70 75 80 85 gca gtc gca tgc atg ggt gcc gtg ttt aat ccg ctg aac aag cag ttg 403 Ala Val Ala Cys Met Gly Ala Val Phe Asn Pro Leu Asn Lys Gln Leu                  90 95 100 atg aat gat cag att gtg ttc att ctc aat cac tct gaa gct gaa gtg 451 Met Asn Asp Gln Ile Val Phe Ile Leu Asn His Ser Glu Ala Glu Val             105 110 115 gtt atc gct gat ccg cgc atg gct gaa caa ttg ggt gag atc tta aaa 499 Val Ile Ala Asp Pro Arg Met Ala Glu Gln Leu Gly Glu Ile Leu Lys         120 125 130 gaa aca cca aaa gtt cgt gcc gtg gtg ttt att gga ccg aat gat ttc 547 Glu Thr Pro Lys Val Arg Ala Val Val Phe Ile Gly Pro Asn Asp Phe     135 140 145 tct agc gcg gcg gcc cac atg ccg gag gga atg aag ctg tat tcc tat 595 Ser Ser Ala Ala Ala His Met Pro Glu Gly Met Lys Leu Tyr Ser Tyr 150 155 160 165 gaa gcg ctc ctt gac ggc cgt tcc act gtt tac aac tgg ccc gag cag 643 Glu Ala Leu Leu Asp Gly Arg Ser Thr Val Tyr Asn Trp Pro Glu Gln                 170 175 180 gat gaa cgc act gct gct gca att tgc tat tcc acc ggt aca tcg gga 691 Asp Glu Arg Thr Ala Ala Ala Ile Cys Tyr Ser Thr Gly Thr Ser Gly             185 190 195 ccg ccg aag ggt gtg gtg tat tcc cac cgc tcg ctt tat tta cag tcg 739 Pro Pro Lys Gly Val Val Tyr Ser His Arg Ser Leu Tyr Leu Gln Ser         200 205 210 ttg agc ttg cgc acc acg gat tcc ctc gca gtg gaa cac ggc gaa acg 787 Leu Ser Leu Arg Thr Thr Asp Ser Leu Ala Val Glu His Gly Glu Thr     215 220 225 ttc ctg tgc tgt gtg ccg att tac cac gtc ctc agc tgg ggc gtg ccg 835 Phe Leu Cys Cys Val Pro Ile Tyr His Val Leu Ser Trp Gly Val Pro 230 235 240 245 atc gca gcg ttt atg tcc ggc act ccc ctg gtg ctt cct gga ccg gat 883 Ile Ala Ala Phe Met Ser Gly Thr Pro Leu Val Leu Pro Gly Pro Asp                 250 255 260 ctt tct gcg ccg aca ttg gca aag atc att tcc acc acg ctg cct cgc 931 Leu Ser Ala Pro Thr Leu Ala Lys Ile Ile Ser Thr Thr Leu Pro Arg             265 270 275 gtg gcg cat ggc gtg cct act ctc tgg att cag ctg atg gtt cac tac 979 Val Ala His Gly Val Pro Thr Leu Trp Ile Gln Leu Met Val His Tyr         280 285 290 ctg aaa aat ccc cca gag cgt atg tct ctg cgt gag cta tac gtg ggc 1027 Leu Lys Asn Pro Pro Glu Arg Met Ser Leu Arg Glu Leu Tyr Val Gly     295 300 305 ggt tct gcg gtg cct cca atc gtg atc acc atg tgg gag cag cgc tat 1075 Gly Ser Ala Val Pro Pro Ile Val Ile Thr Met Trp Glu Gln Arg Tyr 310 315 320 325 ggc gtg gat gtt gtc cac gtg tgg ggt atg acg gaa acc tcc acc gtg 1123 Gly Val Asp Val Val His Val Trp Gly Met Thr Glu Thr Ser Thr Val                 330 335 340 ggt act gtg tct cgc cca cca tca ggt gtt tct ggt gaa agc cgg tgg 1171 Gly Thr Val Ser Arg Pro Pro Ser Gly Val Ser Gly Glu Ser Arg Trp             345 350 355 aat tat cga gtc tcc cag ggc cga ttc ccc gcc tcc ctg cag tac cgc 1219 Asn Tyr Arg Val Ser Gln Gly Arg Phe Pro Ala Ser Leu Gln Tyr Arg         360 365 370 att gtc aac gac ggc cag gtc atg gcg tcc acc gac cgc aac gag ggc 1267 Ile Val Asn Asp Gly Gln Val Met Ala Ser Thr Asp Arg Asn Glu Gly     375 380 385 gag att cag gtc cgc ggt ccg tgg gtg act gca agt tac ttc cac ccc 1315 Glu Ile Gln Val Arg Gly Pro Trp Val Thr Ala Ser Tyr Phe His Pro 390 395 400 405 gat gtg gaa aaa gaa ggt ggc acc gcc tca aca ttc cgc gac cat gac 1363 Asp Val Glu Lys Glu Gly Gly Thr Ala Ser Thr Phe Arg Asp His Asp                 410 415 420 gtt gaa gag gaa aac gat gag ctc ttc acc gcc gac ggc tgg ctg cgc 1411 Val Glu Glu Glu Asn Asp Glu Leu Phe Thr Ala Asp Gly Trp Leu Arg             425 430 435 acc ggg gac gtt gga tct gtc acc agc gat gga ttc ctc acc atc caa 1459 Thr Gly Asp Val Gly Ser Val Thr Ser Asp Gly Phe Leu Thr Ile Gln         440 445 450 gac cgc gcc cgc gat gtc atc cgt tct ggc ggc gag tgg att tac tcc 1507 Asp Arg Ala Arg Asp Val Ile Arg Ser Gly Gly Glu Trp Ile Tyr Ser     455 460 465 gct cag ctg gaa aac ctc atc gtg gct acs gaa gag gtt gtc gaa tgc 1555 Ala Gln Leu Glu Asn Leu Ile Val Ala Xaa Glu Glu Val Val Glu Cys 470 475 480 485 gcc gtc att ggc ttc ccc gat gac aag tgg gtg gaa cgt ccc ctc gca 1603 Ala Val Ile Gly Phe Pro Asp Asp Lys Trp Val Glu Arg Pro Leu Ala                 490 495 500 gtc acc atg ctc tac ccc ggc att gaa cgc acc cgg gaa acc gcc gag 1651 Val Thr Met Leu Tyr Pro Gly Ile Glu Arg Thr Arg Glu Thr Ala Glu             505 510 515 cgc ctc cgc gat caa ctt cgc gac cgc cta ccc aac tgg atg ctg cca 1699 Arg Leu Arg Asp Gln Leu Arg Asp Arg Leu Pro Asn Trp Met Leu Pro         520 525 530 gaa tat tgg aca ttt gtt gat gag gtg gat aaa acc tcc gtc ggt aaa 1747 Glu Tyr Trp Thr Phe Val Asp Glu Val Asp Lys Thr Ser Val Gly Lys     535 540 545 tat gac aag aag gac ctc cgc aac cac ctg cgc aac ggc gat ttc gaa 1795 Tyr Asp Lys Lys Asp Leu Arg Asn His Leu Arg Asn Gly Asp Phe Glu 550 555 560 565 gta att aag ctt aaa ggg cca ggt gar aaa taacttccct atttattccg 1845 Val Ile Lys Leu Lys Gly Pro Gly Xaa Lys                 570 575 gct 1848 <210> 66 <211> 575 <212> PRT <213> Corynebacterium glutamicum <220> <221> VARIANT <222> 479 X223 = Thr <220> <221> VARIANT <222> 574 <223> Xaa = Glu <400> 66 Met Leu Ser Thr Met Gln Asp Val Pro Leu Ser Leu Thr Arg Ile Leu   1 5 10 15 Glu Tyr Gly Ser Thr Val His Gly Asp Thr Leu Ile Thr Thr Trp Gly              20 25 30 Gly Ala Asp Gly Ile Glu Gln Ala Gln Gln Thr Phe Ser Ala Val Gly          35 40 45 Ala Arg Ala Ala Ala Leu Ala His Ala Leu His Asp Ser Leu Gly Ile      50 55 60 Thr Gly Asp Gln Arg Val Ala Ser Met Leu Tyr Asn Cys Ala Glu His  65 70 75 80 Met Glu Thr Met Phe Ala Val Ala Cys Met Gly Ala Val Phe Asn Pro                  85 90 95 Leu Asn Lys Gln Leu Met Asn Asp Gln Ile Val Phe Ile Leu Asn His             100 105 110 Ser Glu Ala Glu Val Val Ile Ala Asp Pro Arg Met Ala Glu Gln Leu         115 120 125 Gly Glu Ile Leu Lys Glu Thr Pro Lys Val Arg Ala Val Val Phe Ile     130 135 140 Gly Pro Asn Asp Phe Ser Ser Ala Ala Ala His Met Pro Glu Gly Met 145 150 155 160 Lys Leu Tyr Ser Tyr Glu Ala Leu Leu Asp Gly Arg Ser Thr Val Tyr                 165 170 175 Asn Trp Pro Glu Gln Asp Glu Arg Thr Ala Ala Ala Ile Cys Tyr Ser             180 185 190 Thr Gly Thr Ser Gly Pro Pro Lys Gly Val Val Tyr Ser His Arg Ser         195 200 205 Leu Tyr Leu Gln Ser Leu Ser Leu Arg Thr Thr Asp Ser Leu Ala Val     210 215 220 Glu His Gly Glu Thr Phe Leu Cys Cys Val Pro Ile Tyr His Val Leu 225 230 235 240 Ser Trp Gly Val Pro Ile Ala Ala Phe Met Ser Gly Thr Pro Leu Val                 245 250 255 Leu Pro Gly Pro Asp Leu Ser Ala Pro Thr Leu Ala Lys Ile Ile Ser             260 265 270 Thr Thr Leu Pro Arg Val Ala His Gly Val Pro Thr Leu Trp Ile Gln         275 280 285 Leu Met Val His Tyr Leu Lys Asn Pro Pro Glu Arg Met Ser Leu Arg     290 295 300 Glu Leu Tyr Val Gly Gly Ser Ala Val Pro Pro Ile Val Ile Thr Met 305 310 315 320 Trp Glu Gln Arg Tyr Gly Val Asp Val Val His Val Trp Gly Met Thr                 325 330 335 Glu Thr Ser Thr Val Gly Thr Val Ser Arg Pro Pro Ser Gly Val Ser             340 345 350 Gly Glu Ser Arg Trp Asn Tyr Arg Val Ser Gln Gly Arg Phe Pro Ala         355 360 365 Ser Leu Gln Tyr Arg Ile Val Asn Asp Gly Gln Val Met Ala Ser Thr     370 375 380 Asp Arg Asn Glu Gly Glu Ile Gln Val Arg Gly Pro Trp Val Thr Ala 385 390 395 400 Ser Tyr Phe His Pro Asp Val Glu Lys Glu Gly Gly Thr Ala Ser Thr                 405 410 415 Phe Arg Asp His Asp Val Glu Glu Glu Asn Asp Glu Leu Phe Thr Ala             420 425 430 Asp Gly Trp Leu Arg Thr Gly Asp Val Gly Ser Val Thr Ser Asp Gly         435 440 445 Phe Leu Thr Ile Gln Asp Arg Ala Arg Asp Val Ile Arg Ser Gly Gly     450 455 460 Glu Trp Ile Tyr Ser Ala Gln Leu Glu Asn Leu Ile Val Ala Xaa Glu 465 470 475 480 Glu Val Val Glu Cys Ala Val Ile Gly Phe Pro Asp Asp Lys Trp Val                 485 490 495 Glu Arg Pro Leu Ala Val Thr Met Leu Tyr Pro Gly Ile Glu Arg Thr             500 505 510 Arg Glu Thr Ala Glu Arg Leu Arg Asp Gln Leu Arg Asp Arg Leu Pro         515 520 525 Asn Trp Met Leu Pro Glu Tyr Trp Thr Phe Val Asp Glu Val Asp Lys     530 535 540 Thr Ser Val Gly Lys Tyr Asp Lys Lys Asp Leu Arg Asn His Leu Arg 545 550 555 560 Asn Gly Asp Phe Glu Val Ile Lys Leu Lys Gly Pro Gly Xaa Lys                 565 570 575 <210> 67 <211> 1401 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1378) <223> RXA01644 <400> 67 gtaggtagag gcttgtggtc actacttgtg gccacatttt aaaaaaatgc acaagaagag 60 aaagcaaagc attatgagta acgccgtagc gcaggacctc atg acc atc gcc gac 115                                             Met Thr Ile Ala Asp                                               1 5 atc gtc gag gcc acg acc act gca ccc atc cca ttc cac atc act gcc 163 Ile Val Glu Ala Thr Thr Thr Ala Pro Ile Pro Phe His Ile Thr Ala                  10 15 20 ttc gat gga agc ttc act ggc cct gaa gat gct ccc tac cag ctg ttt 211 Phe Asp Gly Ser Phe Thr Gly Pro Glu Asp Ala Pro Tyr Gln Leu Phe              25 30 35 gtt gcc aac acg gat gca gta tcc tac atc gca aca gcg cca gga gat 259 Val Ala Asn Thr Asp Ala Val Ser Tyr Ile Ala Thr Ala Pro Gly Asp          40 45 50 ttg ggt ttg gca cgt gcc tac ctc atg gga gac ctc atc gtg gaa ggt 307 Leu Gly Leu Ala Arg Ala Tyr Leu Met Gly Asp Leu Ile Val Glu Gly      55 60 65 gag cat ccc ggc cat cct tat ggg atc ttt gat gcg ttg aag gag ttc 355 Glu His Pro Gly His Pro Tyr Gly Ile Phe Asp Ala Leu Lys Glu Phe  70 75 80 85 tac cgc tgc ttc aaa cgc cca gat gca tcc acc acc ttg cag atc atg 403 Tyr Arg Cys Phe Lys Arg Pro Asp Ala Ser Thr Thr Leu Gln Ile Met                  90 95 100 tgg act ctg cgg aaa atg aat gcc tta aaa ttc cag gaa att cca cca 451 Trp Thr Leu Arg Lys Met Asn Ala Leu Lys Phe Gln Glu Ile Pro Pro             105 110 115 atg gaa caa gcc cct gca tgg cgt aaa gca ctg atc aac ggg cta gca 499 Met Glu Gln Ala Pro Ala Trp Arg Lys Ala Leu Ile Asn Gly Leu Ala         120 125 130 tcc agg cac tcg aaa tcc cgc gac aag aaa gcc att agc tac cac tac 547 Ser Arg His Ser Lys Ser Arg Asp Lys Lys Ala Ile Ser Tyr His Tyr     135 140 145 gac gtg ggc aat gag ttc tac tcc ctg ttt tta gat gat tcc atg acc 595 Asp Val Gly Asn Glu Phe Tyr Ser Leu Phe Leu Asp Asp Ser Met Thr 150 155 160 165 tat acc tgc gcg tat tat cca acg cca gaa tca agt ttg gaa gaa gcc 643 Tyr Thr Cys Ala Tyr Tyr Pro Thr Pro Glu Ser Ser Leu Glu Glu Ala                 170 175 180 caa gaa aac aaa tac cgc ctc atc ttt gaa aaa ctg cgt ctg aaa gaa 691 Gln Glu Asn Lys Tyr Arg Leu Ile Phe Glu Lys Leu Arg Leu Lys Glu             185 190 195 ggc gat cgc ctc cta gac gtg gga tgc ggt tgg gga ggc atg gtc cgc 739 Gly Asp Arg Leu Leu Asp Val Gly Cys Gly Trp Gly Gly Met Val Arg         200 205 210 tac gcc gcc aaa cac ggt gtg aaa gcc atc gga gtt acg ctg tct gaa 787 Tyr Ala Ala Lys His Gly Val Lys Ala Ile Gly Val Thr Leu Ser Glu     215 220 225 cag caa tat gag tgg ggt caa gca gag atc aaa cgc caa ggt ttg gaa 835 Gln Gln Tyr Glu Trp Gly Gln Ala Glu Ile Lys Arg Gln Gly Leu Glu 230 235 240 245 gac ctc gcg gaa att cgc ttc atg gat tac cgc gat gtt cca gaa act 883 Asp Leu Ala Glu Ile Arg Phe Met Asp Tyr Arg Asp Val Pro Glu Thr                 250 255 260 gga ttc gat gcg atc tca gca atc ggc atc att gaa cac atc ggt gtg 931 Gly Phe Asp Ala Ile Ser Ala Ile Gly Ile Ile Glu His Ile Gly Val             265 270 275 aac aac tat ccc gac tac ttt gaa ttg ctc agc agc aaa ctc aaa aca 979 Asn Asn Tyr Pro Asp Tyr Phe Glu Leu Leu Ser Ser Lys Leu Lys Thr         280 285 290 ggc gga ctg atg ctc aac cac agc atc acc tac cca gac aac cgc ccc 1027 Gly Gly Leu Met Leu Asn His Ser Ile Thr Tyr Pro Asp Asn Arg Pro     295 300 305 cgc cac gca ggt gca ttt att gat cgc tac att ttc ccc gac ggt gaa 1075 Arg His Ala Gly Ala Phe Ile Asp Arg Tyr Ile Phe Pro Asp Gly Glu 310 315 320 325 ctc act ggc tct ggc acc ctg atc aag cac atg cag gac aac ggt ttc 1123 Leu Thr Gly Ser Gly Thr Leu Ile Lys His Met Gln Asp Asn Gly Phe                 330 335 340 gaa gtg ctg cac gaa gaa aac ctc cgc ttt gat tac caa cgc acc ctg 1171 Glu Val Leu His Glu Glu Asn Leu Arg Phe Asp Tyr Gln Arg Thr Leu             345 350 355 cac gcg tgg tgc gaa aac ctc aaa gaa aat tgg gag gaa gca gtt gaa 1219 His Ala Trp Cys Glu Asn Leu Lys Glu Asn Trp Glu Glu Ala Val Glu         360 365 370 ctc gcc ggt gaa ccc act gca cga ctc ttt ggc ctg tac atg gca ggt 1267 Leu Ala Gly Glu Pro Thr Ala Arg Leu Phe Gly Leu Tyr Met Ala Gly     375 380 385 tcg gaa tgg gga ttt gcc cac aac atc gtc cag ctg cac caa gta ctg 1315 Ser Glu Trp Gly Phe Ala His Asn Ile Val Gln Leu His Gln Val Leu 390 395 400 405 ggt gtg aaa ctc gat gag cag gga agt cgc gga gaa gtt cct gaa aga 1363 Gly Val Lys Leu Asp Glu Gln Gly Ser Arg Gly Glu Val Pro Glu Arg                 410 415 420 atg tgg tgg act atc taaagaaaca atgtttcttt tta 1401 Met Trp Trp Thr Ile             425 <210> 68 <211> 426 <212> PRT <213> Corynebacterium glutamicum <400> 68 Met Thr Ile Ala Asp Ile Val Glu Ala Thr Thr Thr Ala Pro Ile Pro   1 5 10 15 Phe His Ile Thr Ala Phe Asp Gly Ser Phe Thr Gly Pro Glu Asp Ala              20 25 30 Pro Tyr Gln Leu Phe Val Ala Asn Thr Asp Ala Val Ser Tyr Ile Ala          35 40 45 Thr Ala Pro Gly Asp Leu Gly Leu Ala Arg Ala Tyr Leu Met Gly Asp      50 55 60 Leu Ile Val Glu Gly Glu His Pro Gly His Pro Tyr Gly Ile Phe Asp  65 70 75 80 Ala Leu Lys Glu Phe Tyr Arg Cys Phe Lys Arg Pro Asp Ala Ser Thr                  85 90 95 Thr Leu Gln Ile Met Trp Thr Leu Arg Lys Met Asn Ala Leu Lys Phe             100 105 110 Gln Glu Ile Pro Pro Met Glu Gln Ala Pro Ala Trp Arg Lys Ala Leu         115 120 125 Ile Asn Gly Leu Ala Ser Arg His Ser Lys Ser Arg Asp Lys Lys Ala     130 135 140 Ile Ser Tyr His Tyr Asp Val Gly Asn Glu Phe Tyr Ser Leu Phe Leu 145 150 155 160 Asp Asp Ser Met Thr Tyr Thr Cys Ala Tyr Tyr Pro Thr Pro Glu Ser                 165 170 175 Ser Leu Glu Glu Ala Gln Glu Asn Lys Tyr Arg Leu Ile Phe Glu Lys             180 185 190 Leu Arg Leu Lys Glu Gly Asp Arg Leu Leu Asp Val Gly Cys Gly Trp         195 200 205 Gly Gly Met Val Arg Tyr Ala Ala Lys His Gly Val Lys Ala Ile Gly     210 215 220 Val Thr Leu Ser Glu Gln Gln Tyr Glu Trp Gly Gln Ala Glu Ile Lys 225 230 235 240 Arg Gln Gly Leu Glu Asp Leu Ala Glu Ile Arg Phe Met Asp Tyr Arg                 245 250 255 Asp Val Pro Glu Thr Gly Phe Asp Ala Ile Ser Ala Ile Gly Ile Ile             260 265 270 Glu His Ile Gly Val Asn Asn Tyr Pro Asp Tyr Phe Glu Leu Leu Ser         275 280 285 Ser Lys Leu Lys Thr Gly Gly Leu Met Leu Asn His Ser Ile Thr Tyr     290 295 300 Pro Asp Asn Arg Pro Arg His Ala Gly Ala Phe Ile Asp Arg Tyr Ile 305 310 315 320 Phe Pro Asp Gly Glu Leu Thr Gly Ser Gly Thr Leu Ile Lys His Met                 325 330 335 Gln Asp Asn Gly Phe Glu Val Leu His Glu Glu Asn Leu Arg Phe Asp             340 345 350 Tyr Gln Arg Thr Leu His Ala Trp Cys Glu Asn Leu Lys Glu Asn Trp         355 360 365 Glu Glu Ala Val Glu Leu Ala Gly Glu Pro Thr Ala Arg Leu Phe Gly     370 375 380 Leu Tyr Met Ala Gly Ser Glu Trp Gly Phe Ala His Asn Ile Val Gln 385 390 395 400 Leu His Gln Val Leu Gly Val Lys Leu Asp Glu Gln Gly Ser Arg Gly                 405 410 415 Glu Val Pro Glu Arg Met Trp Trp Thr Ile             420 425 <210> 69 <211> 1437 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (1414) <223> RXA02029 <400> 69 cgcacgtaca ctacttttag cagttaaccc gccgaacttt cttgattaag tattcattga 60 gcgttcttgg cataaatccc actggaggtg catcaaacgt atg gca gag gca cgt 115                                             Met Ala Glu Ala Arg                                               1 5 ttg cgc cat ctt gaa ccc att gat gtg gaa gag tgg cct ggg gtg gcg 163 Leu Arg His Leu Glu Pro Ile Asp Val Glu Glu Trp Pro Gly Val Ala                  10 15 20 tca gtg ccc aac cta gcg ttt gct ggt gca cgc gca cgg caa gca gaa 211 Ser Val Pro Asn Leu Ala Phe Ala Gly Ala Arg Ala Arg Gln Ala Glu              25 30 35 tat cga ttt gcc aag gcc tgc agc aac gca ggt tta gtt ctg cta gga 259 Tyr Arg Phe Ala Lys Ala Cys Ser Asn Ala Gly Leu Val Leu Leu Gly          40 45 50 aat gac ccg gat ctc att att gat cat gag gaa tta ttc tca cgt ttg 307 Asn Asp Pro Asp Leu Ile Ile Asp His Glu Glu Leu Phe Ser Arg Leu      55 60 65 gcc gca tcg ggc tgg ctg ggg ctc gct gag agc tac atg gca ggc gag 355 Ala Ala Ser Gly Trp Leu Gly Leu Ala Glu Ser Tyr Met Ala Gly Glu  70 75 80 85 tgg cgc agc gag agg ctt gcc gac gtc ttg acc gct ttg ttg gga act 403 Trp Arg Ser Glu Arg Leu Ala Asp Val Leu Thr Ala Leu Leu Gly Thr                  90 95 100 ggg ttt aaa ccc cgc ggc aaa cta tct gga tcg ttc acc ctg cca ggg 451 Gly Phe Lys Pro Arg Gly Lys Leu Ser Gly Ser Phe Thr Leu Pro Gly             105 110 115 caa gct gtg gat gcc gga ggc gca cta ccc aat gaa ctc att cgt tta 499 Gln Ala Val Asp Ala Gly Gly Ala Leu Pro Asn Glu Leu Ile Arg Leu         120 125 130 agt tca ggt gat ggc atg agc gca ttt ggt gga gtt ttt gcc tcc ggt 547 Ser Ser Gly Asp Gly Met Ser Ala Phe Gly Gly Val Phe Ala Ser Gly     135 140 145 gtt cca acc act tta cgt acc gca gtg aaa agc cat gtg ccg gga gct 595 Val Pro Thr Thr Leu Arg Thr Ala Val Lys Ser His Val Pro Gly Ala 150 155 160 165 ggt cgc aat agg gag ccc gca tct cac ttt gtg gat atc acc aag atc 643 Gly Arg Asn Arg Glu Pro Ala Ser His Phe Val Asp Ile Thr Lys Ile                 170 175 180 tcg gag cct gtg gcc gtg gag cgt gaa gac ctc ggc gag gct cag cgc 691 Ser Glu Pro Val Ala Val Glu Arg Glu Asp Leu Gly Glu Ala Gln Arg             185 190 195 cga gca gcg tcc ttt ttg ctt gac ggc gcc aaa gtt aaa gcc gga agc 739 Arg Ala Ala Ser Phe Leu Leu Asp Gly Ala Lys Val Lys Ala Gly Ser         200 205 210 cat gtg ttg gag ttt ccc agc agt ggt gga gct tta gct att ttg gct 787 His Val Leu Glu Phe Pro Ser Ser Gly Gly Ala Leu Ala Ile Leu Ala     215 220 225 gct cga cgc cag gga act gtt gac gct tta acg gct gat ccc gcg caa 835 Ala Arg Arg Gln Gly Thr Val Asp Ala Leu Thr Ala Asp Pro Ala Gln 230 235 240 245 gtt tca agc ctg gag gag acg ttt gtg ctc gcc ggt gtg gag gag gat 883 Val Ser Ser Leu Glu Glu Thr Phe Val Leu Ala Gly Val Glu Glu Asp                 250 255 260 att cac atc gag gtc att ccc cag gcg att ccc tcg cca cgc gaa tgg 931 Ile His Ile Glu Val Ile Pro Gln Ala Ile Pro Ser Pro Arg Glu Trp             265 270 275 ggt ggc gcc tac gat tcg ata gtc gcc atg gag aag cta gaa gtg gtg 979 Gly Gly Ala Tyr Asp Ser Ile Val Ala Met Glu Lys Leu Glu Val Val         280 285 290 ggc aag cac ggt tcc aag cgg ttt att aaa gct atc gac aga atg ctc 1027 Gly Lys His Gly Ser Lys Arg Phe Ile Lys Ala Ile Asp Arg Met Leu     295 300 305 acc acc ggc ggc aac gta gcc atg caa tcc ttg gta gct act gac caa 1075 Thr Thr Gly Gly Asn Val Ala Met Gln Ser Leu Val Ala Thr Asp Gln 310 315 320 325 tgg agt cct gtg tgt tct gaa gcg att tct ttg ctc aag gcc tat att 1123 Trp Ser Pro Val Cys Ser Glu Ala Ile Ser Leu Leu Lys Ala Tyr Ile                 330 335 340 tgg cct gcg ctg cat tac cca act gtt gat gaa gtt cat cag ctt gtt 1171 Trp Pro Ala Leu His Tyr Pro Thr Val Asp Glu Val His Gln Leu Val             345 350 355 gat agg gat tct tct ctg cgc gtg gtg aag gaa aca cac ttt gcg ggc 1219 Asp Arg Asp Ser Ser Leu Arg Val Val Lys Glu Thr His Phe Ala Gly         360 365 370 cat tac cta aaa agc gtg cag ttg caa cgt gaa gtg ttt gaa ggc cag 1267 His Tyr Leu Lys Ser Val Gln Leu Gln Arg Glu Val Phe Glu Gly Gln     375 380 385 ata cgc gaa gcg gcg gca gat ggc ttt gat gcc gtc tac cgc cgc atg 1315 Ile Arg Glu Ala Ala Ala Asp Gly Phe Asp Ala Val Tyr Arg Arg Met 390 395 400 405 tgg gtg tat cac tac gcg ctt att gaa gcc ctg tta cgc ctg gga tgt 1363 Trp Val Tyr His Tyr Ala Leu Ile Glu Ala Leu Leu Arg Leu Gly Cys                 410 415 420 ctc aat gca gtg caa ttt gcg ttg acg aca aga aac aga agg ggg cgt 1411 Leu Asn Ala Val Gln Phe Ala Leu Thr Thr Arg Asn Arg Arg Gly Arg             425 430 435 cga taagcaaaaa tcttttagac ctc 1437 Arg <210> 70 <211> 438 <212> PRT <213> Corynebacterium glutamicum <400> 70 Met Ala Glu Ala Arg Leu Arg His Leu Glu Pro Ile Asp Val Glu Glu   1 5 10 15 Trp Pro Gly Val Ala Ser Val Pro Asn Leu Ala Phe Ala Gly Ala Arg              20 25 30 Ala Arg Gln Ala Glu Tyr Arg Phe Ala Lys Ala Cys Ser Asn Ala Gly          35 40 45 Leu Val Leu Leu Gly Asn Asp Pro Asp Leu Ile Ile Asp His Glu Glu      50 55 60 Leu Phe Ser Arg Leu Ala Ala Ser Gly Trp Leu Gly Leu Ala Glu Ser  65 70 75 80 Tyr Met Ala Gly Glu Trp Arg Ser Glu Arg Leu Ala Asp Val Leu Thr                  85 90 95 Ala Leu Leu Gly Thr Gly Phe Lys Pro Arg Gly Lys Leu Ser Gly Ser             100 105 110 Phe Thr Leu Pro Gly Gln Ala Val Asp Ala Gly Gly Ala Leu Pro Asn         115 120 125 Glu Leu Ile Arg Leu Ser Ser Gly Asp Gly Met Ser Ala Phe Gly Gly     130 135 140 Val Phe Ala Ser Gly Val Pro Thr Thr Leu Arg Thr Ala Val Lys Ser 145 150 155 160 His Val Pro Gly Ala Gly Arg Asn Arg Glu Pro Ala Ser His Phe Val                 165 170 175 Asp Ile Thr Lys Ile Ser Glu Pro Val Ala Val Glu Arg Glu Asp Leu             180 185 190 Gly Glu Ala Gln Arg Arg Ala Ala Ser Phe Leu Leu Asp Gly Ala Lys         195 200 205 Val Lys Ala Gly Ser His Val Leu Glu Phe Pro Ser Ser Gly Gly Ala     210 215 220 Leu Ala Ile Leu Ala Ala Arg Arg Gln Gly Thr Val Asp Ala Leu Thr 225 230 235 240 Ala Asp Pro Ala Gln Val Ser Ser Leu Glu Glu Thr Phe Val Leu Ala                 245 250 255 Gly Val Glu Glu Asp Ile His Ile Glu Val Ile Pro Gln Ala Ile Pro             260 265 270 Ser Pro Arg Glu Trp Gly Gly Ala Tyr Asp Ser Ile Val Ala Met Glu         275 280 285 Lys Leu Glu Val Val Gly Lys His Gly Ser Lys Arg Phe Ile Lys Ala     290 295 300 Ile Asp Arg Met Leu Thr Thr Gly Gly Asn Val Ala Met Gln Ser Leu 305 310 315 320 Val Ala Thr Asp Gln Trp Ser Pro Val Cys Ser Glu Ala Ile Ser Leu                 325 330 335 Leu Lys Ala Tyr Ile Trp Pro Ala Leu His Tyr Pro Thr Val Asp Glu             340 345 350 Val His Gln Leu Val Asp Arg Asp Ser Ser Leu Arg Val Val Lys Glu         355 360 365 Thr His Phe Ala Gly His Tyr Leu Lys Ser Val Gln Leu Gln Arg Glu     370 375 380 Val Phe Glu Gly Gln Ile Arg Glu Ala Ala Ala Asp Gly Phe Asp Ala 385 390 395 400 Val Tyr Arg Arg Met Trp Val Tyr His Tyr Ala Leu Ile Glu Ala Leu                 405 410 415 Leu Arg Leu Gly Cys Leu Asn Ala Val Gln Phe Ala Leu Thr Thr Arg             420 425 430 Asn Arg Arg Gly Arg Arg         435 <210> 71 <211> 1140 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1117) <223> RXA01801 <400> 71 tttggattcc tttccgatta tgtcttgatc gcccattctg tcacatccgg gttgtctaaa 60 cacccgcgaa gatttcctgt gatgtgccac actggttctc atg tct aac gta gtg 115                                             Met ser asn val val                                               1 5 aac act ttt gtc cag aat tcc acc ggt atg gtg gag ctt aat cgt ccc 163 Asn Thr Phe Val Gln Asn Ser Thr Gly Met Val Glu Leu Asn Arg Pro                  10 15 20 aaa gcg ctc aat tct ctt aat cag gaa atg atc gat ctc gtt cag gaa 211 Lys Ala Leu Asn Ser Leu Asn Gln Glu Met Ile Asp Leu Val Gln Glu              25 30 35 gct cta acc act tgg gct gat gat gat cag gtg cag cag gtt ctc att 259 Ala Leu Thr Thr Trp Ala Asp Asp Asp Gln Val Gln Gln Val Leu Ile          40 45 50 tac tca tcc tcg gag cgt gca ttt tgt gcc ggc ggt gat gtg cgc gcg 307 Tyr Ser Ser Ser Glu Arg Ala Phe Cys Ala Gly Gly Asp Val Arg Ala      55 60 65 gtc cgt gag agc gtg ttg gag ggc gat gtt gcg gcc ggc gat aag tat 355 Val Arg Glu Ser Val Leu Glu Gly Asp Val Ala Ala Gly Asp Lys Tyr  70 75 80 85 ttc atc gat gag ttc gcg atg aac aac acg ttg gga acc tat ccg aag 403 Phe Ile Asp Glu Phe Ala Met Asn Asn Thr Leu Gly Thr Tyr Pro Lys                  90 95 100 ccg gtc att tct gtg atc aac ggc gtc gcg atg ggt ggc gga atg gga 451 Pro Val Ile Ser Val Ile Asn Gly Val Ala Met Gly Gly Gly Met Gly             105 110 115 att tcc atg cat gga tcg cac cgg atc gtc acg gaa aaa gcg ttc gcg 499 Ile Ser Met His Gly Ser His Arg Ile Val Thr Glu Lys Ala Phe Ala         120 125 130 tcg atg cct gag atg gcg atc ggc tat gtt ccc gat gtg ggc ttt act 547 Ser Met Pro Glu Met Ala Ile Gly Tyr Val Pro Asp Val Gly Phe Thr     135 140 145 tat ttc ggt cag cgt gca tcg tcg ctg gcc atc gcc aca ttt ttg gcg 595 Tyr Phe Gly Gln Arg Ala Ser Ser Leu Ala Ile Ala Thr Phe Leu Ala 150 155 160 165 gtg acc ggg tgg cgc atg agc cct gcc gat atg ctg tgg gct ggc gtc 643 Val Thr Gly Trp Arg Met Ser Pro Ala Asp Met Leu Trp Ala Gly Val                 170 175 180 gca acg cat ttt gtt gag gat gcg cag ggg ttc att gat gcg gtc ttg 691 Ala Thr His Phe Val Glu Asp Ala Gln Gly Phe Ile Asp Ala Val Leu             185 190 195 aac gag tcg ctt gat ggc gcg ctg gag aaa ttc tcc acg caa cct acg 739 Asn Glu Ser Leu Asp Gly Ala Leu Glu Lys Phe Ser Thr Gln Pro Thr         200 205 210 ggc agc agc gag ctg gcc ggc gtc gcc agc cag att gag gag acc ttt 787 Gly Ser Ser Glu Leu Ala Gly Val Ala Ser Gln Ile Glu Glu Thr Phe     215 220 225 ggg cac agc tct tgg gcg ctt atc gac gcc tcc ctc cgg tct cac ccc 835 Gly His Ser Ser Trp Ala Leu Ile Asp Ala Ser Leu Arg Ser His Pro 230 235 240 245 gat gct gaa ttt gtt gcc aag gtg gat ggg ctg atg gcg tcg gca gca 883 Asp Ala Glu Phe Val Ala Lys Val Asp Gly Leu Met Ala Ser Ala Ala                 250 255 260 ccg gca tcg gtg gtg gct acc gtg aag ctg atg cat caa aac agt gag 931 Pro Ala Ser Val Val Ala Thr Val Lys Leu Met His Gln Asn Ser Glu             265 270 275 gcg acc act ctg cgt gaa ggc ttg gac aat gaa ttg gcg atg tct ctt 979 Ala Thr Thr Leu Arg Glu Gly Leu Asp Asn Glu Leu Ala Met Ser Leu         280 285 290 tat atg atc cgc cag cct gat ttt gct gaa ggt gtg cgt gca gtg ttg 1027 Tyr Met Ile Arg Gln Pro Asp Phe Ala Glu Gly Val Arg Ala Val Leu     295 300 305 gtt gat aaa gac cgc aat gca gcc ttc tcc cca gcc aac tac gaa gat 1075 Val Asp Lys Asp Arg Asn Ala Ala Phe Ser Pro Ala Asn Tyr Glu Asp 310 315 320 325 gtt gat gag tca cat ttt gtg acc ttg ttc cag cgc agt tca 1117 Val Asp Glu Ser His Phe Val Thr Leu Phe Gln Arg Ser Ser                 330 335 taaaaccgcc aaacttttga tag 1140 <210> 72 <211> 339 <212> PRT <213> Corynebacterium glutamicum <400> 72 Met Ser Asn Val Val Asn Thr Phe Val Gln Asn Ser Thr Gly Met Val   1 5 10 15 Glu Leu Asn Arg Pro Lys Ala Leu Asn Ser Leu Asn Gln Glu Met Ile              20 25 30 Asp Leu Val Gln Glu Ala Leu Thr Thr Trp Ala Asp Asp Asp Gln Val          35 40 45 Gln Gln Val Leu Ile Tyr Ser Ser Ser Glu Arg Ala Phe Cys Ala Gly      50 55 60 Gly Asp Val Arg Ala Val Arg Glu Ser Val Leu Glu Gly Asp Val Ala  65 70 75 80 Ala Gly Asp Lys Tyr Phe Ile Asp Glu Phe Ala Met Asn Asn Thr Leu                  85 90 95 Gly Thr Tyr Pro Lys Pro Val Ile Ser Val Ile Asn Gly Val Ala Met             100 105 110 Gly Gly Gly Met Gly Ile Ser Met His Gly Ser His Arg Ile Val Thr         115 120 125 Glu Lys Ala Phe Ala Ser Met Pro Glu Met Ala Ile Gly Tyr Val Pro     130 135 140 Asp Val Gly Phe Thr Tyr Phe Gly Gln Arg Ala Ser Ser Leu Ala Ile 145 150 155 160 Ala Thr Phe Leu Ala Val Thr Gly Trp Arg Met Ser Pro Ala Asp Met                 165 170 175 Leu Trp Ala Gly Val Ala Thr His Phe Val Glu Asp Ala Gln Gly Phe             180 185 190 Ile Asp Ala Val Leu Asn Glu Ser Leu Asp Gly Ala Leu Glu Lys Phe         195 200 205 Ser Thr Gln Pro Thr Gly Ser Ser Glu Leu Ala Gly Val Ala Ser Gln     210 215 220 Ile Glu Glu Thr Phe Gly His Ser Ser Trp Ala Leu Ile Asp Ala Ser 225 230 235 240 Leu Arg Ser His Pro Asp Ala Glu Phe Val Ala Lys Val Asp Gly Leu                 245 250 255 Met Ala Ser Ala Ala Pro Ala Ser Val Val Ala Thr Val Lys Leu Met             260 265 270 His Gln Asn Ser Glu Ala Thr Thr Leu Arg Glu Gly Leu Asp Asn Glu         275 280 285 Leu Ala Met Ser Leu Tyr Met Ile Arg Gln Pro Asp Phe Ala Glu Gly     290 295 300 Val Arg Ala Val Leu Val Asp Lys Asp Arg Asn Ala Ala Phe Ser Pro 305 310 315 320 Ala Asn Tyr Glu Asp Val Asp Glu Ser His Phe Val Thr Leu Phe Gln                 325 330 335 Arg Ser Ser <210> 73 <211> 1086 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (101) .. (1063) <223> RXN02512 <400> 73 gctggaaagt ccccattggc taaggaattt accaaggcac cagcaggtgc gaaggcagat 60 tacagcaaca ccaaataaaa attagccgag ggagcatcgc atg aag ccg aag gat 115                                             Met Lys Pro Lys Asp                                               1 5 ttc tgc aca gcg gaa aat tgg gcg gag aat tta agc gca ctg ggc tat 163 Phe Cys Thr Ala Glu Asn Trp Ala Glu Asn Leu Ser Ala Leu Gly Tyr                  10 15 20 cta gct ggt tgg cgt ttt gtc cgg atg ctc cct ttg cct att gct cgc 211 Leu Ala Gly Trp Arg Phe Val Arg Met Leu Pro Leu Pro Ile Ala Arg              25 30 35 cgg gtg ttt gac ctt ggg gcg gat ctg gcg tcg aaa agc gga aaa ggc 259 Arg Val Phe Asp Leu Gly Ala Asp Leu Ala Ser Lys Ser Gly Lys Gly          40 45 50 atg ggg cag cta cgc gct aat ctg gcg cgg gtg gtc ggt gcg gaa aac 307 Met Gly Gln Leu Arg Ala Asn Leu Ala Arg Val Val Gly Ala Glu Asn      55 60 65 gtt acg cag gcg ctg gtg aag caa gca acg cgc agc tat gcg cgg tat 355 Val Thr Gln Ala Leu Val Lys Gln Ala Thr Arg Ser Tyr Ala Arg Tyr  70 75 80 85 tgg ctg gaa gcg ttc cgg cta ccg gcg atc gcg cga gat cct gag ctg 403 Trp Leu Glu Ala Phe Arg Leu Pro Ala Ile Ala Arg Asp Pro Glu Leu                  90 95 100 ctt gcg cgg ttg cgt aag gga act gtt ggc cta gat ttg ttg gat gaa 451 Leu Ala Arg Leu Arg Lys Gly Thr Val Gly Leu Asp Leu Leu Asp Glu             105 110 115 tct ttg gct gcc ggc aag ggc gta gtt ttg acg ctc cca cac agc ggc 499 Ser Leu Ala Ala Gly Lys Gly Val Val Leu Thr Leu Pro His Ser Gly         120 125 130 aac tgg gat atg gct ggc gct ttt ctg att agc cat cat ggg caa ttc 547 Asn Trp Asp Met Ala Gly Ala Phe Leu Ile Ser His His Gly Gln Phe     135 140 145 acc acc gtt gca gaa agg gtc aag ccg gaa cgc ttg ttt gaa gcg ttc 595 Thr Thr Val Ala Glu Arg Val Lys Pro Glu Arg Leu Phe Glu Ala Phe 150 155 160 165 gtg gag ttt cga gaa agc ctt gga ttt gag gtg ctg cct ctc acc ggt 643 Val Glu Phe Arg Glu Ser Leu Gly Phe Glu Val Leu Pro Leu Thr Gly                 170 175 180 ggc gag cgt ccg ccg ttt gaa aag ctg aaa gag cgc ctg aca tct gga 691 Gly Glu Arg Pro Pro Phe Glu Lys Leu Lys Glu Arg Leu Thr Ser Gly             185 190 195 ggt atc gtg tgc ctt ctt ggg gag cgt gac ctg cgg cat tcc ggc gtg 739 Gly Ile Val Cys Leu Leu Gly Glu Arg Asp Leu Arg His Ser Gly Val         200 205 210 gag acc act ttt ttt ggt gag aag acc tcc atg cca gca gga cct gcg 787 Glu Thr Thr Phe Phe Gly Glu Lys Thr Ser Met Pro Ala Gly Pro Ala     215 220 225 cag ctg gcc att gaa aca ggt gcg gcg ctg cac gtg gtg cat cca tgg 835 Gln Leu Ala Ile Glu Thr Gly Ala Ala Leu His Val Val His Pro Trp 230 235 240 245 ttc gat gac gac ggc tgg ggt ctc agc gta tcc gat gcc gtg acc gtg 883 Phe Asp Asp Asp Gly Trp Gly Leu Ser Val Ser Asp Ala Val Thr Val                 250 255 260 gat aat tta tcc gac acg gtg cag cgg atc gca cat ctt ttt atg gca 931 Asp Asn Leu Ser Asp Thr Val Gln Arg Ile Ala His Leu Phe Met Ala             265 270 275 aat att acg gcg cac ccc gct gat tgg cat atg ctc caa ccc ctg tgg 979 Asn Ile Thr Ala His Pro Ala Asp Trp His Met Leu Gln Pro Leu Trp         280 285 290 ttt ggt gat ttg gat ccg gag cgt ctc aag cgc tct agg gag cag aca 1027 Phe Gly Asp Leu Asp Pro Glu Arg Leu Lys Arg Ser Arg Glu Gln Thr     295 300 305 aat gtt cac aaa ccg gtg gca tta cag gag gac aat taggtgcgaa 1073 Asn Val His Lys Pro Val Ala Leu Gln Glu Asp Asn 310 315 320 ttggaatggt ctg 1086 <210> 74 <211> 321 <212> PRT <213> Corynebacterium glutamicum <400> 74 Met Lys Pro Lys Asp Phe Cys Thr Ala Glu Asn Trp Ala Glu Asn Leu   1 5 10 15 Ser Ala Leu Gly Tyr Leu Ala Gly Trp Arg Phe Val Arg Met Leu Pro              20 25 30 Leu Pro Ile Ala Arg Arg Val Phe Asp Leu Gly Ala Asp Leu Ala Ser          35 40 45 Lys Ser Gly Lys Gly Met Gly Gln Leu Arg Ala Asn Leu Ala Arg Val      50 55 60 Val Gly Ala Glu Asn Val Thr Gln Ala Leu Val Lys Gln Ala Thr Arg  65 70 75 80 Ser Tyr Ala Arg Tyr Trp Leu Glu Ala Phe Arg Leu Pro Ala Ile Ala                  85 90 95 Arg Asp Pro Glu Leu Leu Ala Arg Leu Arg Lys Gly Thr Val Gly Leu             100 105 110 Asp Leu Leu Asp Glu Ser Leu Ala Ala Gly Lys Gly Val Val Leu Thr         115 120 125 Leu Pro His Ser Gly Asn Trp Asp Met Ala Gly Ala Phe Leu Ile Ser     130 135 140 His His Gly Gln Phe Thr Thr Val Ala Glu Arg Val Lys Pro Glu Arg 145 150 155 160 Leu Phe Glu Ala Phe Val Glu Phe Arg Glu Ser Leu Gly Phe Glu Val                 165 170 175 Leu Pro Leu Thr Gly Gly Glu Arg Pro Pro Phe Glu Lys Leu Lys Glu             180 185 190 Arg Leu Thr Ser Gly Gly Ile Val Cys Leu Leu Gly Glu Arg Asp Leu         195 200 205 Arg His Ser Gly Val Glu Thr Thr Phe Phe Gly Glu Lys Thr Ser Met     210 215 220 Pro Ala Gly Pro Ala Gln Leu Ala Ile Glu Thr Gly Ala Ala Leu His 225 230 235 240 Val Val His Pro Trp Phe Asp Asp Asp Gly Trp Gly Leu Ser Val Ser                 245 250 255 Asp Ala Val Thr Val Asp Asn Leu Ser Asp Thr Val Gln Arg Ile Ala             260 265 270 His Leu Phe Met Ala Asn Ile Thr Ala His Pro Ala Asp Trp His Met         275 280 285 Leu Gln Pro Leu Trp Phe Gly Asp Leu Asp Pro Glu Arg Leu Lys Arg     290 295 300 Ser Arg Glu Gln Thr Asn Val His Lys Pro Val Ala Leu Gln Glu Asp 305 310 315 320 Asn <210> 75 <211> 1057 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1057) <223> FRXA02512 <400> 75 gctggaaagt ccccattggc taaggaattt accaaggcac cagcaggtgc gaaggcagat 60 tacagcaaca ccaaataaaa attagccgag ggagcatcgc atg aag ccg aag gat 115                                             Met Lys Pro Lys Asp                                               1 5 ttc tgc aca gcg gaa aat tgg gcg gag aat tta agc gca ctg ggc tat 163 Phe Cys Thr Ala Glu Asn Trp Ala Glu Asn Leu Ser Ala Leu Gly Tyr                  10 15 20 cta gct ggt tgg cgt ttt gtc cgg atg ctc cct ttg cct att gct cgc 211 Leu Ala Gly Trp Arg Phe Val Arg Met Leu Pro Leu Pro Ile Ala Arg              25 30 35 cgg gtg ttt gac ctt ggg gcg gat ctg gcg tcg aaa agc gga aaa ggc 259 Arg Val Phe Asp Leu Gly Ala Asp Leu Ala Ser Lys Ser Gly Lys Gly          40 45 50 atg ggg cag cta cgc gct aat ctg gcg cgg gtg gtc ggt gcg gaa aac 307 Met Gly Gln Leu Arg Ala Asn Leu Ala Arg Val Val Gly Ala Glu Asn      55 60 65 gtt acg cag gcg ctg gtg aag caa gca acg cgc agc tat gcg cgg tat 355 Val Thr Gln Ala Leu Val Lys Gln Ala Thr Arg Ser Tyr Ala Arg Tyr  70 75 80 85 tgg ctg gaa gcg ttc cgg cta ccg gcg atc gcg cga gat cct gag ctg 403 Trp Leu Glu Ala Phe Arg Leu Pro Ala Ile Ala Arg Asp Pro Glu Leu                  90 95 100 ctt gcg cgg ttg cgt aag gga act gtt ggc cta gat ttg ttg gat gaa 451 Leu Ala Arg Leu Arg Lys Gly Thr Val Gly Leu Asp Leu Leu Asp Glu             105 110 115 tct ttg gct gcc ggc aag ggc gta gtt ttg acg ctc cca cac agc ggc 499 Ser Leu Ala Ala Gly Lys Gly Val Val Leu Thr Leu Pro His Ser Gly         120 125 130 aac tgg gat atg gct ggc gct ttt ctg att agc cat cat ggg caa ttc 547 Asn Trp Asp Met Ala Gly Ala Phe Leu Ile Ser His His Gly Gln Phe     135 140 145 acc acc gtt gca gaa agg gtc aag ccg gaa cgc ttg ttt gaa gcg ttc 595 Thr Thr Val Ala Glu Arg Val Lys Pro Glu Arg Leu Phe Glu Ala Phe 150 155 160 165 gtg gag ttt cga gaa agc ctt gga ttt gag gtg ctg cct ctc acc ggt 643 Val Glu Phe Arg Glu Ser Leu Gly Phe Glu Val Leu Pro Leu Thr Gly                 170 175 180 ggc gag cgt ccg ccg ttt gaa aag ctg aaa gag cgc ctg aca tct gga 691 Gly Glu Arg Pro Pro Phe Glu Lys Leu Lys Glu Arg Leu Thr Ser Gly             185 190 195 ggt atc gtg tgc ctt ctt ggg gag cgt gac ctg cgg cat tcc ggc gtg 739 Gly Ile Val Cys Leu Leu Gly Glu Arg Asp Leu Arg His Ser Gly Val         200 205 210 gag acc act ttt ttt ggt gag aag acc tcc atg cca gca gga cct gcg 787 Glu Thr Thr Phe Phe Gly Glu Lys Thr Ser Met Pro Ala Gly Pro Ala     215 220 225 cag ctg gcc att gaa aca ggt gcg gcg ctg cac gtg gtg cat cca tgg 835 Gln Leu Ala Ile Glu Thr Gly Ala Ala Leu His Val Val His Pro Trp 230 235 240 245 ttc gat gac gac ggc tgg ggt ctc agc gta tcc gat gcc gtg acc gtg 883 Phe Asp Asp Asp Gly Trp Gly Leu Ser Val Ser Asp Ala Val Thr Val                 250 255 260 gat aat tta tcc gac acg gtg cag cgg atc gca cat ctt ttt atg gca 931 Asp Asn Leu Ser Asp Thr Val Gln Arg Ile Ala His Leu Phe Met Ala             265 270 275 aat att acg gcg cac ccc gct gat tgg cat atg ctc caa ccc ctg tgg 979 Asn Ile Thr Ala His Pro Ala Asp Trp His Met Leu Gln Pro Leu Trp         280 285 290 ttt ggt gat ttg gat ccg gag cgt ctc aag cgc tct agg gag cag aca 1027 Phe Gly Asp Leu Asp Pro Glu Arg Leu Lys Arg Ser Arg Glu Gln Thr     295 300 305 aat gtt cac aaa ccg gtg gca tta cag gag 1057 Asn Val His Lys Pro Val Ala Leu Gln Glu 310 315 <210> 76 <211> 319 <212> PRT <213> Corynebacterium glutamicum <400> 76 Met Lys Pro Lys Asp Phe Cys Thr Ala Glu Asn Trp Ala Glu Asn Leu   1 5 10 15 Ser Ala Leu Gly Tyr Leu Ala Gly Trp Arg Phe Val Arg Met Leu Pro              20 25 30 Leu Pro Ile Ala Arg Arg Val Phe Asp Leu Gly Ala Asp Leu Ala Ser          35 40 45 Lys Ser Gly Lys Gly Met Gly Gln Leu Arg Ala Asn Leu Ala Arg Val      50 55 60 Val Gly Ala Glu Asn Val Thr Gln Ala Leu Val Lys Gln Ala Thr Arg  65 70 75 80 Ser Tyr Ala Arg Tyr Trp Leu Glu Ala Phe Arg Leu Pro Ala Ile Ala                  85 90 95 Arg Asp Pro Glu Leu Leu Ala Arg Leu Arg Lys Gly Thr Val Gly Leu             100 105 110 Asp Leu Leu Asp Glu Ser Leu Ala Ala Gly Lys Gly Val Val Leu Thr         115 120 125 Leu Pro His Ser Gly Asn Trp Asp Met Ala Gly Ala Phe Leu Ile Ser     130 135 140 His His Gly Gln Phe Thr Thr Val Ala Glu Arg Val Lys Pro Glu Arg 145 150 155 160 Leu Phe Glu Ala Phe Val Glu Phe Arg Glu Ser Leu Gly Phe Glu Val                 165 170 175 Leu Pro Leu Thr Gly Gly Glu Arg Pro Pro Phe Glu Lys Leu Lys Glu             180 185 190 Arg Leu Thr Ser Gly Gly Ile Val Cys Leu Leu Gly Glu Arg Asp Leu         195 200 205 Arg His Ser Gly Val Glu Thr Thr Phe Phe Gly Glu Lys Thr Ser Met     210 215 220 Pro Ala Gly Pro Ala Gln Leu Ala Ile Glu Thr Gly Ala Ala Leu His 225 230 235 240 Val Val His Pro Trp Phe Asp Asp Asp Gly Trp Gly Leu Ser Val Ser                 245 250 255 Asp Ala Val Thr Val Asp Asn Leu Ser Asp Thr Val Gln Arg Ile Ala             260 265 270 His Leu Phe Met Ala Asn Ile Thr Ala His Pro Ala Asp Trp His Met         275 280 285 Leu Gln Pro Leu Trp Phe Gly Asp Leu Asp Pro Glu Arg Leu Lys Arg     290 295 300 Ser Arg Glu Gln Thr Asn Val His Lys Pro Val Ala Leu Gln Glu 305 310 315 <210> 77 <211> 1389 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (1366) <223> RXA00899 <400> 77 tttgctgctc ccctacgtcg gactcccact gttcctgctt atgggatcgc catacatcaa 60 ccggtgacgc caccgcatcc aacaagaaat caacgacctc atg gaa gac gtc cac 115                                             Met Glu Asp Val His                                               1 5 gac gac gtc ccc gac atc ccc acc gga atg gat gtc tcc gcg gaa gtt 163 Asp Asp Val Pro Asp Ile Pro Thr Gly Met Asp Val Ser Ala Glu Val                  10 15 20 gaa tct gtc atc aaa ctc aac cgc cgc ctc acc cgc atg cca gca gtg 211 Glu Ser Val Ile Lys Leu Asn Arg Arg Leu Thr Arg Met Pro Ala Val              25 30 35 acc ggc gga aac aac ggc ttc tac tcc gac tac cgt gaa tcc ctc aaa 259 Thr Gly Gly Asn Asn Gly Phe Tyr Ser Asp Tyr Arg Glu Ser Leu Lys          40 45 50 cgg atg acc gcc gca atc gac gaa gcc gaa gaa tac atc tac gtc gag 307 Arg Met Thr Ala Ala Ile Asp Glu Ala Glu Glu Tyr Ile Tyr Val Glu      55 60 65 atc tac atc atg gcc tgg gat tcc tac acc caa cca ttc ttc gca gca 355 Ile Tyr Ile Met Ala Trp Asp Ser Tyr Thr Gln Pro Phe Phe Ala Ala  70 75 80 85 ctc gaa cga gcc cac aac cgc ggc gtc aaa gtc cga ctc ctt ttc gac 403 Leu Glu Arg Ala His Asn Arg Gly Val Lys Val Arg Leu Leu Phe Asp                  90 95 100 cac gtc ggc agc tgg aaa tac ccc ggc tac cac cgc ctc aaa aaa gaa 451 His Val Gly Ser Trp Lys Tyr Pro Gly Tyr His Arg Leu Lys Lys Glu             105 110 115 ctc aac cgc atg ggc ttc gcc tgg tac ctc atg ctc ccc ctc caa ccc 499 Leu Asn Arg Met Gly Phe Ala Trp Tyr Leu Met Leu Pro Leu Gln Pro         120 125 130 tgg cga cgc cgc ttc cgc cga ccc gac ctg cgc aac cac cgc aaa atg 547 Trp Arg Arg Arg Phe Arg Arg Pro Asp Leu Arg Asn His Arg Lys Met     135 140 145 ctc atc atc gac ggc cac acc gca ttc atg ggc tcc caa aat ctc atc 595 Leu Ile Ile Asp Gly His Thr Ala Phe Met Gly Ser Gln Asn Leu Ile 150 155 160 165 gcc ccg agt tac cta caa aag aaa aac atc aaa ctc ggc cgc gaa tgg 643 Ala Pro Ser Tyr Leu Gln Lys Lys Asn Ile Lys Leu Gly Arg Glu Trp                 170 175 180 aaa gac ctc atg gtc gaa ctc acc ggc ccc atc gtc tcc tcc atg gaa 691 Lys Asp Leu Met Val Glu Leu Thr Gly Pro Ile Val Ser Ser Met Glu             185 190 195 atg atc ttc gcc ggc gac tgg tac gtc gaa tcc aac gaa gcc ctc gac 739 Met Ile Phe Ala Gly Asp Trp Tyr Val Glu Ser Asn Glu Ala Leu Asp         200 205 210 atc cgc gac cac gca gaa gcc cac ggc tac atc ggc aac act caa aaa 787 Ile Arg Asp His Ala Glu Ala His Gly Tyr Ile Gly Asn Thr Gln Lys     215 220 225 gac tcc gcc acc aac ctc gtg cag ctc atc ccc tcc ggc cct ggt tac 835 Asp Ser Ala Thr Asn Leu Val Gln Leu Ile Pro Ser Gly Pro Gly Tyr 230 235 240 245 acc aca gaa ccc aac ctg cgc atg ttc aac tcc atc gtt cac cac gcc 883 Thr Thr Glu Pro Asn Leu Arg Met Phe Asn Ser Ile Val His His Ala                 250 255 260 aaa gaa cga ctc atc ttg tgc agc ccc tac ttc atc ccc gac gaa tcc 931 Lys Glu Arg Leu Ile Leu Cys Ser Pro Tyr Phe Ile Pro Asp Glu Ser             265 270 275 ctc ctc gaa gcc gtc acc tca gcc tgc tac cgc gga gta acc gtc gaa 979 Leu Leu Glu Ala Val Thr Ser Ala Cys Tyr Arg Gly Val Thr Val Glu         280 285 290 cta ttc gtc tct gaa caa gcc gac caa ttc gcc atc gac cac gcc caa 1027 Leu Phe Val Ser Glu Gln Ala Asp Gln Phe Ala Ile Asp His Ala Gln     295 300 305 tcc tcc tac tac cag gca ctc ctt gaa gcc ggc gtg aaa atc tac caa 1075 Ser Ser Tyr Tyr Gln Ala Leu Leu Glu Ala Gly Val Lys Ile Tyr Gln 310 315 320 325 ttc ccc aaa ccc gac gtc ctc cac acc aag tac atg atc gcc gac ccc 1123 Phe Pro Lys Pro Asp Val Leu His Thr Lys Tyr Met Ile Ala Asp Pro                 330 335 340 gac gac acc acc ggc aac gaa gcc ctc gga gtc ctc gga tcc tcc aac 1171 Asp Asp Thr Thr Gly Asn Glu Ala Leu Gly Val Leu Gly Ser Ser Asn             345 350 355 ctc gac atc cgc agc ttt ggc ctc aac tac gaa atc tcc ctg atg atc 1219 Leu Asp Ile Arg Ser Phe Gly Leu Asn Tyr Glu Ile Ser Leu Met Ile         360 365 370 gcc aaa ggc aac ctc atc cac gaa ctc aac gcc ctc acc gac cgt tac 1267 Ala Lys Gly Asn Leu Ile His Glu Leu Asn Ala Leu Thr Asp Arg Tyr     375 380 385 cgc aca gta agt ttc aag ctc acc ttg gat aag tgg aac cag cgc agt 1315 Arg Thr Val Ser Phe Lys Leu Thr Leu Asp Lys Trp Asn Gln Arg Ser 390 395 400 405 tgg cgg cgc cgc tac gtg gac aat gtc atg cgt ttg acc tcg gcg ctg 1363 Trp Arg Arg Arg Tyr Val Asp Asn Val Met Arg Leu Thr Ser Ala Leu                 410 415 420 cag tagtttggcg cgtttggagt gcg 1389 Gln <210> 78 <211> 422 <212> PRT <213> Corynebacterium glutamicum <400> 78 Met Glu Asp Val His Asp Asp Val Pro Asp Ile Pro Thr Gly Met Asp   1 5 10 15 Val Ser Ala Glu Val Glu Ser Val Ile Lys Leu Asn Arg Arg Leu Thr              20 25 30 Arg Met Pro Ala Val Thr Gly Gly Asn Asn Gly Phe Tyr Ser Asp Tyr          35 40 45 Arg Glu Ser Leu Lys Arg Met Thr Ala Ala Ile Asp Glu Ala Glu Glu      50 55 60 Tyr Ile Tyr Val Glu Ile Tyr Ile Met Ala Trp Asp Ser Tyr Thr Gln  65 70 75 80 Pro Phe Phe Ala Ala Leu Glu Arg Ala His Asn Arg Gly Val Lys Val                  85 90 95 Arg Leu Leu Phe Asp His Val Gly Ser Trp Lys Tyr Pro Gly Tyr His             100 105 110 Arg Leu Lys Lys Glu Leu Asn Arg Met Gly Phe Ala Trp Tyr Leu Met         115 120 125 Leu Pro Leu Gln Pro Trp Arg Arg Arg Phe Arg Arg Pro Asp Leu Arg     130 135 140 Asn His Arg Lys Met Leu Ile Ile Asp Gly His Thr Ala Phe Met Gly 145 150 155 160 Ser Gln Asn Leu Ile Ala Pro Ser Tyr Leu Gln Lys Lys Asn Ile Lys                 165 170 175 Leu Gly Arg Glu Trp Lys Asp Leu Met Val Glu Leu Thr Gly Pro Ile             180 185 190 Val Ser Ser Met Glu Met Ile Phe Ala Gly Asp Trp Tyr Val Glu Ser         195 200 205 Asn Glu Ala Leu Asp Ile Arg Asp His Ala Glu Ala His Gly Tyr Ile     210 215 220 Gly Asn Thr Gln Lys Asp Ser Ala Thr Asn Leu Val Gln Leu Ile Pro 225 230 235 240 Ser Gly Pro Gly Tyr Thr Thr Glu Pro Asn Leu Arg Met Phe Asn Ser                 245 250 255 Ile Val His His Ala Lys Glu Arg Leu Ile Leu Cys Ser Pro Tyr Phe             260 265 270 Ile Pro Asp Glu Ser Leu Leu Glu Ala Val Thr Ser Ala Cys Tyr Arg         275 280 285 Gly Val Thr Val Glu Leu Phe Val Ser Glu Gln Ala Asp Gln Phe Ala     290 295 300 Ile Asp His Ala Gln Ser Ser Tyr Tyr Gln Ala Leu Leu Glu Ala Gly 305 310 315 320 Val Lys Ile Tyr Gln Phe Pro Lys Pro Asp Val Leu His Thr Lys Tyr                 325 330 335 Met Ile Ala Asp Pro Asp Asp Thr Thr Gly Asn Glu Ala Leu Gly Val             340 345 350 Leu Gly Ser Ser Asn Leu Asp Ile Arg Ser Phe Gly Leu Asn Tyr Glu         355 360 365 Ile Ser Leu Met Ile Ala Lys Gly Asn Leu Ile His Glu Leu Asn Ala     370 375 380 Leu Thr Asp Arg Tyr Arg Thr Val Ser Phe Lys Leu Thr Leu Asp Lys 385 390 395 400 Trp Asn Gln Arg Ser Trp Arg Arg Arg Tyr Val Asp Asn Val Met Arg                 405 410 415 Leu Thr Ser Ala Leu Gln             420 <210> 79 <211> 1452 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1429) <223> RXN00819 <220> <221> misc_feature <222> 1264 <223> n indicates any nucleotide <220> <221> misc_feature <222> 1267 <223> n indicates any nucleotide <220> <221> misc_feature <222> 1268 <223> n indicates any nucleotide <220> <221> misc_feature <222> 1279 <223> n indicates any nucleotide <220> <221> misc_feature <222> 1281 <223> n indicates any nucleotide <220> <221> misc_feature <222> 1285 <223> n indicates any nucleotide <220> <221> misc_feature <222> 1301 <223> n indicates any nucleotide <220> <221> misc_feature <222> 1304 <223> n indicates any nucleotide <220> <221> VARIANT <222> 390 <223> Xaa = Ser, Pro, Thr, or Ala <220> <221> VARIANT <222> 394 Xaa = Leu, Pro, His, or Arg <220> <221> VARIANT <222> 401 Xaa = Tyr, His, Asn, or Asp <220> <221> VARIANT <222> 402 <223> Xaa = Ser, Pro, Thr, or Ala <400> 79 gatgaggttc gtccgggaat cctcaaagac aatgcggtga aggtacttgg cctagccgct 60 agcactgagc gcggatctca agcagaaaag gtcgtgcaac atg cgt gat ccc att 115                                             Met Arg Asp Pro Ile                                               1 5 caa ggt gct gtt att cct tct gat ctt ttt ggt ttc gca gaa gtt ctc 163 Gln Gly Ala Val Ile Pro Ser Asp Leu Phe Gly Phe Ala Glu Val Leu                  10 15 20 acc gaa gcc gaa cgc gca gtt ctt ctg gaa acc cgc agg gtg ctt gag 211 Thr Glu Ala Glu Arg Ala Val Leu Leu Glu Thr Arg Arg Val Leu Glu              25 30 35 gaa gag gtg aag cct tat att aat gag gcc tgg gat aag gca gtc ttc 259 Glu Glu Val Lys Pro Tyr Ile Asn Glu Ala Trp Asp Lys Ala Val Phe          40 45 50 ccc gat gag atc gtg cag ccc ctc caa gat ctg caa ttg ctt gat ccg 307 Pro Asp Glu Ile Val Gln Pro Leu Gln Asp Leu Gln Leu Leu Asp Pro      55 60 65 cct gca ctt cgg gaa gca ggg gag tcg gtt cga gac att ttc act ggt 355 Pro Ala Leu Arg Glu Ala Gly Glu Ser Val Arg Asp Ile Phe Thr Gly  70 75 80 85 ttc cgc aat ttt gaa ctc gcg cgc tgt gac atc aat gtt ggt acc tat 403 Phe Arg Asn Phe Glu Leu Ala Arg Cys Asp Ile Asn Val Gly Thr Tyr                  90 95 100 tac aac gca tct gct ggt ctc ttc cga acg gcc tgc atg gtt ggt ggc 451 Tyr Asn Ala Ser Ala Gly Leu Phe Arg Thr Ala Cys Met Val Gly Gly             105 110 115 tcc ccg gag cag gcg cag cga ttg gat gcg cag atc aaa tct ggt gag 499 Ser Pro Glu Gln Ala Gln Arg Leu Asp Ala Gln Ile Lys Ser Gly Glu         120 125 130 gtc aag ggc gtt ttt gca ctg acg gaa cct gat cat ggc tct gat atc 547 Val Lys Gly Val Phe Ala Leu Thr Glu Pro Asp His Gly Ser Asp Ile     135 140 145 gca ggt ggt ctg gca acc acg gcc act aag gac gca gac acc ggc gag 595 Ala Gly Gly Leu Ala Thr Thr Ala Thr Lys Asp Ala Asp Thr Gly Glu 150 155 160 165 tgg att atc aat ggt gaa aaa cgg tgg atc ggt ggt gct tcc act gct 643 Trp Ile Ile Asn Gly Glu Lys Arg Trp Ile Gly Gly Ala Ser Thr Ala                 170 175 180 gat ttg atc gct acc ttc gcc agg gat aca gcc gat aac cag gtg aaa 691 Asp Leu Ile Ala Thr Phe Ala Arg Asp Thr Ala Asp Asn Gln Val Lys             185 190 195 tgc ttc ctc gtg gca cct cag gca gag ggc gtg tcc atg gag att att 739 Cys Phe Leu Val Ala Pro Gln Ala Glu Gly Val Ser Met Glu Ile Ile         200 205 210 gat cgc aaa gcc tca ctg cgc atc atg caa aat gca cac att acc tat 787 Asp Arg Lys Ala Ser Leu Arg Ile Met Gln Asn Ala His Ile Thr Tyr     215 220 225 aac aat gtc cgg gtg tct ggg gat gcg cgg ctg cac aac atc aat tct 835 Asn Asn Val Arg Val Ser Gly Asp Ala Arg Leu His Asn Ile Asn Ser 230 235 240 245 ttc aag gat gtt tcg gaa tgc ctg cgc cgt atg cgt tcc gat gtg gcg 883 Phe Lys Asp Val Ser Glu Cys Leu Arg Arg Met Arg Ser Asp Val Ala                 250 255 260 tgg atg gcg gtc ggt gcg cag gca ggt gcc tat gaa gca gcc gtg aag 931 Trp Met Ala Val Gly Ala Gln Ala Gly Ala Tyr Glu Ala Ala Val Lys             265 270 275 tat gtg cgc agc agg gaa cag ttt ggc cgt ccg atc gcg ggg ttc cag 979 Tyr Val Arg Ser Arg Glu Gln Phe Gly Arg Pro Ile Ala Gly Phe Gln         280 285 290 ttg att cag gaa aag ctc gcg ctc atg ctg ggc aat ctc acg gcg tcg 1027 Leu Ile Gln Glu Lys Leu Ala Leu Met Leu Gly Asn Leu Thr Ala Ser     295 300 305 ctg ggc atg atg gtc aaa ctc acc gat cag cag cag gcg gga att ttc 1075 Leu Gly Met Met Val Lys Leu Thr Asp Gln Gln Gln Ala Gly Ile Phe 310 315 320 325 aaa gag gaa aac tcc gcg ctg gcg aaa atg ttt acc tcg ctc aaa ctt 1123 Lys Glu Glu Asn Ser Ala Leu Ala Lys Met Phe Thr Ser Leu Lys Leu                 330 335 340 cgg gag acc gct agt tgg gcg cgg gaa atc tgc gga ggc aac ggc atc 1171 Arg Glu Thr Ala Ser Trp Ala Arg Glu Ile Cys Gly Gly Asn Gly Ile             345 350 355 att ttg gac aac gat gtt gcc cgg ttc cat gcc gat gca gaa gcc gtc 1219 Ile Leu Asp Asn Asp Val Ala Arg Phe His Ala Asp Ala Glu Ala Val         360 365 370 tat tca tat gaa ggc acc cac gaa atc aat gca ctc atc gtt ggn cgn 1267 Tyr Ser Tyr Glu Gly Thr His Glu Ile Asn Ala Leu Ile Val Gly Arg     375 380 385 ncc att ctg ggn cnt ctn ttc ttt tta tat tat nac nct ttt gag gag 1315 Xaa Ile Leu Gly Xaa Leu Phe Phe Leu Tyr Tyr Xaa Xaa Phe Glu Glu 390 395 400 405 gat ctt cat gac tac ttc cac cac ccc aaa cca tcg ttt ctt tcg aag 1363 Asp Leu His Asp Tyr Phe His His Pro Lys Pro Ser Phe Leu Ser Lys                 410 415 420 acg cac caa ccc tca ccg gcc agg acc tgg gct ttt cgc agt ggc gca 1411 Thr His Gln Pro Ser Pro Ala Arg Thr Trp Ala Phe Arg Ser Gly Ala             425 430 435 ctg tca ccc agg aga tgg tgaacacctt ggcggacgca act 1452 Leu Ser Pro Arg Arg Trp         440 <210> 80 <211> 443 <212> PRT <213> Corynebacterium glutamicum <220> <221> VARIANT <222> 390 <223> Xaa = Ser, Pro, Thr, or Ala <220> <221> VARIANT <222> 394 Xaa = Leu, Pro, His, or Arg <220> <221> VARIANT <222> 401 Xaa = Tyr, His, Asn, or Asp <220> <221> VARIANT <222> 402 <223> Xaa = Ser, Pro, Thr, or Ala <400> 80 Met Arg Asp Pro Ile Gln Gly Ala Val Ile Pro Ser Asp Leu Phe Gly   1 5 10 15 Phe Ala Glu Val Leu Thr Glu Ala Glu Arg Ala Val Leu Leu Glu Thr              20 25 30 Arg Arg Val Leu Glu Glu Glu Val Lys Pro Tyr Ile Asn Glu Ala Trp          35 40 45 Asp Lys Ala Val Phe Pro Asp Glu Ile Val Gln Pro Leu Gln Asp Leu      50 55 60 Gln Leu Leu Asp Pro Pro Ala Leu Arg Glu Ala Gly Glu Ser Val Arg  65 70 75 80 Asp Ile Phe Thr Gly Phe Arg Asn Phe Glu Leu Ala Arg Cys Asp Ile                  85 90 95 Asn Val Gly Thr Tyr Tyr Asn Ala Ser Ala Gly Leu Phe Arg Thr Ala             100 105 110 Cys Met Val Gly Gly Ser Pro Glu Gln Ala Gln Arg Leu Asp Ala Gln         115 120 125 Ile Lys Ser Gly Glu Val Lys Gly Val Phe Ala Leu Thr Glu Pro Asp     130 135 140 His Gly Ser Asp Ile Ala Gly Gly Leu Ala Thr Thr Ala Thr Lys Asp 145 150 155 160 Ala Asp Thr Gly Glu Trp Ile Ile Asn Gly Glu Lys Arg Trp Ile Gly                 165 170 175 Gly Ala Ser Thr Ala Asp Leu Ile Ala Thr Phe Ala Arg Asp Thr Ala             180 185 190 Asp Asn Gln Val Lys Cys Phe Leu Val Ala Pro Gln Ala Glu Gly Val         195 200 205 Ser Met Glu Ile Ile Asp Arg Lys Ala Ser Leu Arg Ile Met Gln Asn     210 215 220 Ala His Ile Thr Tyr Asn Asn Val Arg Val Ser Gly Asp Ala Arg Leu 225 230 235 240 His Asn Ile Asn Ser Phe Lys Asp Val Ser Glu Cys Leu Arg Arg Met                 245 250 255 Arg Ser Asp Val Ala Trp Met Ala Val Gly Ala Gln Ala Gly Ala Tyr             260 265 270 Glu Ala Ala Val Lys Tyr Val Arg Ser Arg Glu Gln Phe Gly Arg Pro         275 280 285 Ile Ala Gly Phe Gln Leu Ile Gln Glu Lys Leu Ala Leu Met Leu Gly     290 295 300 Asn Leu Thr Ala Ser Leu Gly Met Met Val Lys Leu Thr Asp Gln Gln 305 310 315 320 Gln Ala Gly Ile Phe Lys Glu Glu Asn Ser Ala Leu Ala Lys Met Phe                 325 330 335 Thr Ser Leu Lys Leu Arg Glu Thr Ala Ser Trp Ala Arg Glu Ile Cys             340 345 350 Gly Gly Asn Gly Ile Ile Leu Asp Asn Asp Val Ala Arg Phe His Ala         355 360 365 Asp Ala Glu Ala Val Tyr Ser Tyr Glu Gly Thr His Glu Ile Asn Ala     370 375 380 Leu Ile Val Gly Arg Xaa Ile Leu Gly Xaa Leu Phe Phe Leu Tyr Tyr 385 390 395 400 Xaa Xaa Phe Glu Glu Asp Leu His Asp Tyr Phe His His Pro Lys Pro                 405 410 415 Ser Phe Leu Ser Lys Thr His Gln Pro Ser Pro Ala Arg Thr Trp Ala             420 425 430 Phe Arg Ser Gly Ala Leu Ser Pro Arg Arg Trp         435 440 <210> 81 <211> 1030 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (18) .. (1007) <223> FRXA00819 <220> <221> misc_feature <222> 842 <223> n indicates any nucleotide <220> <221> misc_feature <222> 845 <223> n indicates any nucleotide <220> <221> misc_feature <222> 846 <223> n indicates any nucleotide <220> <221> misc_feature <222> 857 <223> n indicates any nucleotide <220> <221> misc_feature <222> 859 <223> n indicates any nucleotide <220> <221> misc_feature <222> 863 <223> n indicates any nucleotide <220> <221> misc_feature <222> 879 <223> n indicates any nucleotide <220> <221> misc_feature <222> 882 <223> n indicates any nucleotide <220> <221> VARIANT <222> 277 <223> Xaa = Ser, Pro, Thr, or Ala <220> <221> VARIANT <222> 281 Xaa = Leu, Pro, His, or Arg <220> <221> VARIANT <222> 288 Xaa = Tyr, His, Asn, or Asp <220> <221> VARIANT <222> 289 <223> Xaa = Ser, Pro, Thr, or Ala <400> 81 tcttccgaac ggcctgc atg gtt ggt ggc tcc ccg gag cag gcg cag cga 50                    Met Val Gly Gly Ser Pro Glu Gln Ala Gln Arg                      1 5 10 ttg gat gcg cag atc aaa tct ggt gag gtc aag ggc gtt ttt gca ctg 98 Leu Asp Ala Gln Ile Lys Ser Gly Glu Val Lys Gly Val Phe Ala Leu              15 20 25 acg gaa cct gat cat ggc tct gat atc gca ggt ggt ctg gca acc acg 146 Thr Glu Pro Asp His Gly Ser Asp Ile Ala Gly Gly Leu Ala Thr Thr          30 35 40 gcc act aag gac gca gac acc ggc gag tgg att atc aat ggt gaa aaa 194 Ala Thr Lys Asp Ala Asp Thr Gly Glu Trp Ile Ile Asn Gly Glu Lys      45 50 55 cgg tgg atc ggt ggt gct tcc act gct gat ttg atc gct acc ttc gcc 242 Arg Trp Ile Gly Gly Ala Ser Thr Ala Asp Leu Ile Ala Thr Phe Ala  60 65 70 75 agg gat aca gcc gat aac cag gtg aaa tgc ttc ctc gtg gca cct cag 290 Arg Asp Thr Ala Asp Asn Gln Val Lys Cys Phe Leu Val Ala Pro Gln                  80 85 90 gca gag ggc gtg tcc atg gag att att gat cgc aaa gcc tca ctg cgc 338 Ala Glu Gly Val Ser Met Glu Ile Ile Asp Arg Lys Ala Ser Leu Arg              95 100 105 atc atg caa aat gca cac att acc tat aac aat gtc cgg gtg tct ggg 386 Ile Met Gln Asn Ala His Ile Thr Tyr Asn Asn Val Arg Val Ser Gly         110 115 120 gat gcg cgg ctg cac aac atc aat tct ttc aag gat gtt tcg gaa tgc 434 Asp Ala Arg Leu His Asn Ile Asn Ser Phe Lys Asp Val Ser Glu Cys     125 130 135 ctg cgc cgt atg cgt tcc gat gtg gcg tgg atg gcg gtc ggt gcg cag 482 Leu Arg Arg Met Arg Ser Asp Val Ala Trp Met Ala Val Gly Ala Gln 140 145 150 155 gca ggt gcc tat gaa gca gcc gtg aag tat gtg cgc agc agg gaa cag 530 Ala Gly Ala Tyr Glu Ala Ala Val Lys Tyr Val Arg Ser Arg Glu Gln                 160 165 170 ttt ggc cgt ccg atc gcg ggg ttc cag ttg att cag gaa aag ctc gcg 578 Phe Gly Arg Pro Ile Ala Gly Phe Gln Leu Ile Gln Glu Lys Leu Ala             175 180 185 ctc atg ctg ggc aat ctc acg gcg tcg ctg ggc atg atg gtc aaa ctc 626 Leu Met Leu Gly Asn Leu Thr Ala Ser Leu Gly Met Met Val Lys Leu         190 195 200 acc gat cag cag cag gcg gga att ttc aaa gag gaa aac tcc gcg ctg 674 Thr Asp Gln Gln Gln Ala Gly Ile Phe Lys Glu Glu Asn Ser Ala Leu     205 210 215 gcg aaa atg ttt acc tcg ctc aaa ctt cgg gag acc gct agt tgg gcg 722 Ala Lys Met Phe Thr Ser Leu Lys Leu Arg Glu Thr Ala Ser Trp Ala 220 225 230 235 cgg gaa atc tgc gga ggc aac ggc atc att ttg gac aac gat gtt gcc 770 Arg Glu Ile Cys Gly Gly Asn Gly Ile Ile Leu Asp Asn Asp Val Ala                 240 245 250 cgg ttc cat gcc gat gca gaa gcc gtc tat tca tat gaa ggc acc cac 818 Arg Phe His Ala Asp Ala Glu Ala Val Tyr Ser Tyr Glu Gly Thr His             255 260 265 gaa atc aat gca ctc atc gtt ggn cgn ncc att ctg ggn cnt ctn ttc 866 Glu Ile Asn Ala Leu Ile Val Gly Arg Xaa Ile Leu Gly Xaa Leu Phe         270 275 280 ttt tta tat tat nac nct ttt gag gag gat ctt cat gac tac ttc cac 914 Phe Leu Tyr Tyr Xaa Xaa Phe Glu Glu Asp Leu His Asp Tyr Phe His     285 290 295 cac ccc aaa cca tcg ttt ctt tcg aag acg cac caa ccc tca ccg gcc 962 His Pro Lys Pro Ser Phe Leu Ser Lys Thr His Gln Pro Ser Pro Ala 300 305 310 315 agg acc tgg gct ttt cgc agt ggc gca ctg tca ccc agg aga tgg 1007 Arg Thr Trp Ala Phe Arg Ser Gly Ala Leu Ser Pro Arg Arg Trp                 320 325 330 tgaacacctt cgcggacgca act 1030 <210> 82 <211> 330 <212> PRT <213> Corynebacterium glutamicum <220> <221> VARIANT <222> 277 <223> Xaa = Ser, Pro, Thr, or Ala <220> <221> VARIANT <222> 281 Xaa = Leu, Pro, His, or Arg <220> <221> VARIANT <222> 288 Xaa = Tyr, His, Asn, or Asp <220> <221> VARIANT <222> 289 <223> Xaa = Ser, Pro, Thr, or Ala <400> 82 Met Val Gly Gly Ser Pro Glu Gln Ala Gln Arg Leu Asp Ala Gln Ile   1 5 10 15 Lys Ser Gly Glu Val Lys Gly Val Phe Ala Leu Thr Glu Pro Asp His              20 25 30 Gly Ser Asp Ile Ala Gly Gly Leu Ala Thr Thr Ala Thr Lys Asp Ala          35 40 45 Asp Thr Gly Glu Trp Ile Ile Asn Gly Glu Lys Arg Trp Ile Gly Gly      50 55 60 Ala Ser Thr Ala Asp Leu Ile Ala Thr Phe Ala Arg Asp Thr Ala Asp  65 70 75 80 Asn Gln Val Lys Cys Phe Leu Val Ala Pro Gln Ala Glu Gly Val Ser                  85 90 95 Met Glu Ile Ile Asp Arg Lys Ala Ser Leu Arg Ile Met Gln Asn Ala             100 105 110 His Ile Thr Tyr Asn Asn Val Arg Val Ser Gly Asp Ala Arg Leu His         115 120 125 Asn Ile Asn Ser Phe Lys Asp Val Ser Glu Cys Leu Arg Arg Met Arg     130 135 140 Ser Asp Val Ala Trp Met Ala Val Gly Ala Gln Ala Gly Ala Tyr Glu 145 150 155 160 Ala Ala Val Lys Tyr Val Arg Ser Arg Glu Gln Phe Gly Arg Pro Ile                 165 170 175 Ala Gly Phe Gln Leu Ile Gln Glu Lys Leu Ala Leu Met Leu Gly Asn             180 185 190 Leu Thr Ala Ser Leu Gly Met Met Val Lys Leu Thr Asp Gln Gln Gln         195 200 205 Ala Gly Ile Phe Lys Glu Glu Asn Ser Ala Leu Ala Lys Met Phe Thr     210 215 220 Ser Leu Lys Leu Arg Glu Thr Ala Ser Trp Ala Arg Glu Ile Cys Gly 225 230 235 240 Gly Asn Gly Ile Ile Leu Asp Asn Asp Val Ala Arg Phe His Ala Asp                 245 250 255 Ala Glu Ala Val Tyr Ser Tyr Glu Gly Thr His Glu Ile Asn Ala Leu             260 265 270 Ile Val Gly Arg Xaa Ile Leu Gly Xaa Leu Phe Phe Leu Tyr Tyr Xaa         275 280 285 Xaa Phe Glu Glu Asp Leu His Asp Tyr Phe His His Pro Lys Pro Ser     290 295 300 Phe Leu Ser Lys Thr His Gln Pro Ser Pro Ala Arg Thr Trp Ala Phe 305 310 315 320 Arg Ser Gly Ala Leu Ser Pro Arg Arg Trp                 325 330 <210> 83 <211> 391 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (391) <223> FRXA01766 <400> 83 gatgaggttc gtccgggaat cctcaaagac aatgcggtga aggtacttgg cctagccgct 60 agcactgagc gcggatctca agcagaaaag gtcgtgcaac atg cgt gat ccc att 115                                             Met Arg Asp Pro Ile                                               1 5 caa ggt gct gtt att cct tct gat ctt ttt ggt ttc gca gaa gtt ctc 163 Gln Gly Ala Val Ile Pro Ser Asp Leu Phe Gly Phe Ala Glu Val Leu                  10 15 20 acc gaa gcc gaa cgc gca gtt ctt ctg gaa acc cgc agg gtg ctt gag 211 Thr Glu Ala Glu Arg Ala Val Leu Leu Glu Thr Arg Arg Val Leu Glu              25 30 35 gaa gag gtg aag cct tat att aat gag gcc tgg gat aag gca gtc ttc 259 Glu Glu Val Lys Pro Tyr Ile Asn Glu Ala Trp Asp Lys Ala Val Phe          40 45 50 ccc gat gag atc gtg cag ccc ctc caa gat ctg caa ttg ctt gat ccg 307 Pro Asp Glu Ile Val Gln Pro Leu Gln Asp Leu Gln Leu Leu Asp Pro      55 60 65 cct gca ctt cgg gaa gca ggg gag tcg gtt cga gac att ttc act ggt 355 Pro Ala Leu Arg Glu Ala Gly Glu Ser Val Arg Asp Ile Phe Thr Gly  70 75 80 85 ttc cgc aat ttt gaa ctc gcg cgc tgt gac atc aat 391 Phe Arg Asn Phe Glu Leu Ala Arg Cys Asp Ile Asn                  90 95 <210> 84 <211> 97 <212> PRT <213> Corynebacterium glutamicum <400> 84 Met Arg Asp Pro Ile Gln Gly Ala Val Ile Pro Ser Asp Leu Phe Gly   1 5 10 15 Phe Ala Glu Val Leu Thr Glu Ala Glu Arg Ala Val Leu Leu Glu Thr              20 25 30 Arg Arg Val Leu Glu Glu Glu Val Lys Pro Tyr Ile Asn Glu Ala Trp          35 40 45 Asp Lys Ala Val Phe Pro Asp Glu Ile Val Gln Pro Leu Gln Asp Leu      50 55 60 Gln Leu Leu Asp Pro Pro Ala Leu Arg Glu Ala Gly Glu Ser Val Arg  65 70 75 80 Asp Ile Phe Thr Gly Phe Arg Asn Phe Glu Leu Ala Arg Cys Asp Ile                  85 90 95 Asn <210> 85 <211> 1659 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (1636) <223> RXN01762 <400> 85 tggagtgatg aattttccta tagaacgttt tttaaacgat tgacttttta aacgtttacg 60 cttttaatga cttcaaacgt gatctaaagc acaaaggaga atg aaa gtg aac ctc 115                                             Met Lys Val Asn Leu                                               1 5 gga ata gga agc tac cca cga cgc agg gca act gtt cga cca gag tcc 163 Gly Ile Gly Ser Tyr Pro Arg Arg Arg Ala Thr Val Arg Pro Glu Ser                  10 15 20 act gca atc gaa ttc gaa ggc acc agc atc acc tac gga gaa ttc agc 211 Thr Ala Ile Glu Phe Glu Gly Thr Ser Ile Thr Tyr Gly Glu Phe Ser              25 30 35 aaa cga gtc aat cgg ctt gga cat gct ctt cta gac ctc ggc gtt gcg 259 Lys Arg Val Asn Arg Leu Gly His Ala Leu Leu Asp Leu Gly Val Ala          40 45 50 cac caa gat cga gta gct tat gtc gga ttc aac cac cct gcc ctg cta 307 His Gln Asp Arg Val Ala Tyr Val Gly Phe Asn His Pro Ala Leu Leu      55 60 65 gaa gtg ttc ttt tca acg aac ctc att ggg gca aca ccc gtg ctt gtt 355 Glu Val Phe Phe Ser Thr Asn Leu Ile Gly Ala Thr Pro Val Leu Val  70 75 80 85 aac cct cgc cta tcg gca aac gaa atc gat tac atc atc caa gac agc 403 Asn Pro Arg Leu Ser Ala Asn Glu Ile Asp Tyr Ile Ile Gln Asp Ser                  90 95 100 ggt gcg agc atc gtg ttt tac gga atc gac ctc atc gag cac gcc act 451 Gly Ala Ser Ile Val Phe Tyr Gly Ile Asp Leu Ile Glu His Ala Thr             105 110 115 tac ctc caa gaa ctc cat cca gag atc atc atg gtg gcc gtt gaa ggc 499 Tyr Leu Gln Glu Leu His Pro Glu Ile Ile Met Val Ala Val Glu Gly         120 125 130 gat gag ggt cca ggt ttg cgt cga aaa gcg ctt att gaa gcg gcg agc 547 Asp Glu Gly Pro Gly Leu Arg Arg Lys Ala Leu Ile Glu Ala Ala Ser     135 140 145 gac gcc gac atc gac cta gaa gtc agc gat gat gac ctg gtg ctg ctc 595 Asp Ala Asp Ile Asp Leu Glu Val Ser Asp Asp Asp Leu Val Leu Leu 150 155 160 165 atg tac acc tcc gga acc act ggc cgc cca aag ggc gcc atg tta tcc 643 Met Tyr Thr Ser Gly Thr Thr Gly Arg Pro Lys Gly Ala Met Leu Ser                 170 175 180 cac cga aac ctc ttc ttt aac tac ttc aat gcc ctg ctc agc cag gaa 691 His Arg Asn Leu Phe Phe Asn Tyr Phe Asn Ala Leu Leu Ser Gln Glu             185 190 195 att gaa caa ggc gcg gta ctt tta tcc act gcg ccg tta ttc cac atc 739 Ile Glu Gln Gly Ala Val Leu Leu Ser Thr Ala Pro Leu Phe His Ile         200 205 210 gcg ggc ctc aac atg acc acc atc ccg gtg atg atg aag ggc gga aag 787 Ala Gly Leu Asn Met Thr Thr Ile Pro Val Met Met Lys Gly Gly Lys     215 220 225 gtg atc atc cac cgc gaa ttc cgg gca gag cac gtc ctc gac gaa atc 835 Val Ile Ile His Arg Glu Phe Arg Ala Glu His Val Leu Asp Glu Ile 230 235 240 245 gaa cgc tcc aag gta tcc gaa tcc ttc atg gtg cca gcg atg atc gac 883 Glu Arg Ser Lys Val Ser Glu Ser Phe Met Val Pro Ala Met Ile Asp                 250 255 260 atg ttg tcc aac cac cca tca ttt gcc gaa cgc gac ctt tct tcc ctt 931 Met Leu Ser Asn His Pro Ser Phe Ala Glu Arg Asp Leu Ser Ser Leu             265 270 275 cgc gcc atc atg gtg ggc ggc tct ccc ctt agc gaa cgt gcg ctg cga 979 Arg Ala Ile Met Val Gly Gly Ser Pro Leu Ser Glu Arg Ala Leu Arg         280 285 290 atc tgg caa gga cgc gac gta aaa att gtc caa ggc ttc ggc atg aca 1027 Ile Trp Gln Gly Arg Asp Val Lys Ile Val Gln Gly Phe Gly Met Thr     295 300 305 gaa acc gca ccg ggc gcc tgt atc ctc gag gca aca gac aca agc aca 1075 Glu Thr Ala Pro Gly Ala Cys Ile Leu Glu Ala Thr Asp Thr Ser Thr 310 315 320 325 cac ctt gga acc gca ggt cga gcc cac ttc ttc acc gac atc aaa cta 1123 His Leu Gly Thr Ala Gly Arg Ala His Phe Phe Thr Asp Ile Lys Leu                 330 335 340 gtg gac ccg aaa acc ggc gaa gaa gtc ccc acc gga gag gcc ggc gaa 1171 Val Asp Pro Lys Thr Gly Glu Glu Val Pro Thr Gly Glu Ala Gly Glu             345 350 355 gtt ctc atc cgc gga cca cat gtg atg acc gga tac tgg aac cga cca 1219 Val Leu Ile Arg Gly Pro His Val Met Thr Gly Tyr Trp Asn Arg Pro         360 365 370 gaa gac acc gcc agc gca cta caa aat ggc tgg tac cac tcc gga gat 1267 Glu Asp Thr Ala Ser Ala Leu Gln Asn Gly Trp Tyr His Ser Gly Asp     375 380 385 atc gcc atc aaa gat gaa gac ggc tac tac acc atc aaa gac cgc atc 1315 Ile Ala Ile Lys Asp Glu Asp Gly Tyr Tyr Thr Ile Lys Asp Arg Ile 390 395 400 405 aaa gac atg tac atc tcc ggc ggc gaa aac att tac ccc gca gaa gtc 1363 Lys Asp Met Tyr Ile Ser Gly Gly Glu Asn Ile Tyr Pro Ala Glu Val                 410 415 420 gaa caa gca ctc cag gaa ctg gaa gca gtc ctt gat gcc gca gtc atc 1411 Glu Gln Ala Leu Gln Glu Leu Glu Ala Val Leu Asp Ala Ala Val Ile             425 430 435 gga gtc ccc gat gaa cga tgg ggc gaa act ggc atc gcc ttt gtc tcc 1459 Gly Val Pro Asp Glu Arg Trp Gly Glu Thr Gly Ile Ala Phe Val Ser         440 445 450 atc cga gaa agc tac ctg acc aac cca cca acc gga ccg gaa cta cga 1507 Ile Arg Glu Ser Tyr Leu Thr Asn Pro Pro Thr Gly Pro Glu Leu Arg     455 460 465 gaa cta cta ggc agt gtc cta gcc aga tac aaa ctt cca cga gaa atc 1555 Glu Leu Leu Gly Ser Val Leu Ala Arg Tyr Lys Leu Pro Arg Glu Ile 470 475 480 485 cac atc atc gaa gaa ctc ccc cgc aac gcc aca ggc aaa atc caa aag 1603 His Ile Ile Glu Glu Leu Pro Arg Asn Ala Thr Gly Lys Ile Gln Lys                 490 495 500 aac atc ctg cga gac ttc acc atc ccc gtt tca taaacccccc aacgtcactt 1656 Asn Ile Leu Arg Asp Phe Thr Ile Pro Val Ser             505 510 tga 1659 <210> 86 <211> 512 <212> PRT <213> Corynebacterium glutamicum <400> 86 Met Lys Val Asn Leu Gly Ile Gly Ser Tyr Pro Arg Arg Arg Ala Thr   1 5 10 15 Val Arg Pro Glu Ser Thr Ala Ile Glu Phe Glu Gly Thr Ser Ile Thr              20 25 30 Tyr Gly Glu Phe Ser Lys Arg Val Asn Arg Leu Gly His Ala Leu Leu          35 40 45 Asp Leu Gly Val Ala His Gln Asp Arg Val Ala Tyr Val Gly Phe Asn      50 55 60 His Pro Ala Leu Leu Glu Val Phe Phe Ser Thr Asn Leu Ile Gly Ala  65 70 75 80 Thr Pro Val Leu Val Asn Pro Arg Leu Ser Ala Asn Glu Ile Asp Tyr                  85 90 95 Ile Ile Gln Asp Ser Gly Ala Ser Ile Val Phe Tyr Gly Ile Asp Leu             100 105 110 Ile Glu His Ala Thr Tyr Leu Gln Glu Leu His Pro Glu Ile Ile Met         115 120 125 Val Ala Val Glu Gly Asp Glu Gly Pro Gly Leu Arg Arg Lys Ala Leu     130 135 140 Ile Glu Ala Ala Ser Asp Ala Asp Ile Asp Leu Glu Val Ser Asp Asp 145 150 155 160 Asp Leu Val Leu Leu Met Tyr Thr Ser Gly Thr Thr Gly Arg Pro Lys                 165 170 175 Gly Ala Met Leu Ser His Arg Asn Leu Phe Phe Asn Tyr Phe Asn Ala             180 185 190 Leu Leu Ser Gln Glu Ile Glu Gln Gly Ala Val Leu Leu Ser Thr Ala         195 200 205 Pro Leu Phe His Ile Ala Gly Leu Asn Met Thr Thr Ile Pro Val Met     210 215 220 Met Lys Gly Gly Lys Val Ile Ile His Arg Glu Phe Arg Ala Glu His 225 230 235 240 Val Leu Asp Glu Ile Glu Arg Ser Lys Val Ser Glu Ser Phe Met Val                 245 250 255 Pro Ala Met Ile Asp Met Leu Ser Asn His Pro Ser Phe Ala Glu Arg             260 265 270 Asp Leu Ser Ser Leu Arg Ala Ile Met Val Gly Gly Ser Pro Leu Ser         275 280 285 Glu Arg Ala Leu Arg Ile Trp Gln Gly Arg Asp Val Lys Ile Val Gln     290 295 300 Gly Phe Gly Met Thr Glu Thr Ala Pro Gly Ala Cys Ile Leu Glu Ala 305 310 315 320 Thr Asp Thr Ser Thr His Leu Gly Thr Ala Gly Arg Ala His Phe Phe                 325 330 335 Thr Asp Ile Lys Leu Val Asp Pro Lys Thr Gly Glu Glu Val Pro Thr             340 345 350 Gly Glu Ala Gly Glu Val Leu Ile Arg Gly Pro His Val Met Thr Gly         355 360 365 Tyr Trp Asn Arg Pro Glu Asp Thr Ala Ser Ala Leu Gln Asn Gly Trp     370 375 380 Tyr His Ser Gly Asp Ile Ala Ile Lys Asp Glu Asp Gly Tyr Tyr Thr 385 390 395 400 Ile Lys Asp Arg Ile Lys Asp Met Tyr Ile Ser Gly Gly Glu Asn Ile                 405 410 415 Tyr Pro Ala Glu Val Glu Gln Ala Leu Gln Glu Leu Glu Ala Val Leu             420 425 430 Asp Ala Ala Val Ile Gly Val Pro Asp Glu Arg Trp Gly Glu Thr Gly         435 440 445 Ile Ala Phe Val Ser Ile Arg Glu Ser Tyr Leu Thr Asn Pro Pro Thr     450 455 460 Gly Pro Glu Leu Arg Glu Leu Leu Gly Ser Val Leu Ala Arg Tyr Lys 465 470 475 480 Leu Pro Arg Glu Ile His Ile Ile Glu Glu Leu Pro Arg Asn Ala Thr                 485 490 495 Gly Lys Ile Gln Lys Asn Ile Leu Arg Asp Phe Thr Ile Pro Val Ser             500 505 510 <210> 87 <211> 1372 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (101) .. (1363) <223> FRXA01762 <400> 87 tggagtgatg aattttccta tagaacgttt tttaaacgat tgacttttta aacgtttacg 60 cttttaatga cttcaaacgt gatctaaagc acaaaggaga atg aaa gtg aac ctc 115                                             Met Lys Val Asn Leu                                               1 5 gga ata gga agc tac cca cga cgc agg gca act gtt cga cca gag tcc 163 Gly Ile Gly Ser Tyr Pro Arg Arg Arg Ala Thr Val Arg Pro Glu Ser                  10 15 20 act gca atc gaa ttc gaa ggc acc agc atc acc tac gga gaa ttc agc 211 Thr Ala Ile Glu Phe Glu Gly Thr Ser Ile Thr Tyr Gly Glu Phe Ser              25 30 35 aaa cga gtc aat cgg ctt gga cat gct ctt cta gac ctc ggc gtt gcg 259 Lys Arg Val Asn Arg Leu Gly His Ala Leu Leu Asp Leu Gly Val Ala          40 45 50 cac caa gat cga gta gct tat gtc gga ttc aac cac cct gcc ctg cta 307 His Gln Asp Arg Val Ala Tyr Val Gly Phe Asn His Pro Ala Leu Leu      55 60 65 gaa gtg ttc ttt tca acg aac ctc att ggg gca aca ccc gtg ctt gtt 355 Glu Val Phe Phe Ser Thr Asn Leu Ile Gly Ala Thr Pro Val Leu Val  70 75 80 85 aac cct cgc cta tcg gca aac gaa atc gat tac atc atc caa gac agc 403 Asn Pro Arg Leu Ser Ala Asn Glu Ile Asp Tyr Ile Ile Gln Asp Ser                  90 95 100 ggt gcg agc atc gtg ttt tac gga atc gac ctc atc gag cac gcc act 451 Gly Ala Ser Ile Val Phe Tyr Gly Ile Asp Leu Ile Glu His Ala Thr             105 110 115 tac ctc caa gaa ctc cat cca gag atc atc atg gtg gcc gtt gaa ggc 499 Tyr Leu Gln Glu Leu His Pro Glu Ile Ile Met Val Ala Val Glu Gly         120 125 130 gat gag ggt cca ggt ttg cgt cga aaa gcg ctt att gaa gcg gcg agc 547 Asp Glu Gly Pro Gly Leu Arg Arg Lys Ala Leu Ile Glu Ala Ala Ser     135 140 145 gac gcc gac atc gac cta gaa gtc agc gat gat gac ctg gtg ctg ctc 595 Asp Ala Asp Ile Asp Leu Glu Val Ser Asp Asp Asp Leu Val Leu Leu 150 155 160 165 atg tac acc tcc gga acc act ggc cgc cca aag ggc gcc atg tta tcc 643 Met Tyr Thr Ser Gly Thr Thr Gly Arg Pro Lys Gly Ala Met Leu Ser                 170 175 180 cac cga aac ctc ttc ttt aac tac ttc aat gcc ctg ctc agc cag gaa 691 His Arg Asn Leu Phe Phe Asn Tyr Phe Asn Ala Leu Leu Ser Gln Glu             185 190 195 att gaa caa ggc gcg gta ctt tta tcc act gcg ccg tta ttc cac atc 739 Ile Glu Gln Gly Ala Val Leu Leu Ser Thr Ala Pro Leu Phe His Ile         200 205 210 gcg ggc ctc aac atg acc acc atc ccg gtg atg atg aag ggc gga aag 787 Ala Gly Leu Asn Met Thr Thr Ile Pro Val Met Met Lys Gly Gly Lys     215 220 225 gtg atc atc cac cgc gaa ttc cgg gca gag cac gtc ctc gac gaa atc 835 Val Ile Ile His Arg Glu Phe Arg Ala Glu His Val Leu Asp Glu Ile 230 235 240 245 gaa cgc tcc aag gta tcc gaa tcc ttc atg gtg cca gcg atg atc gac 883 Glu Arg Ser Lys Val Ser Glu Ser Phe Met Val Pro Ala Met Ile Asp                 250 255 260 atg ttg tcc aac cac cca tca ttt gcc gaa cgc gac ctt tct tcc ctt 931 Met Leu Ser Asn His Pro Ser Phe Ala Glu Arg Asp Leu Ser Ser Leu             265 270 275 cgc gcc atc atg gtg ggc ggc tct ccc ctt agc gaa cgt gcg ctg cga 979 Arg Ala Ile Met Val Gly Gly Ser Pro Leu Ser Glu Arg Ala Leu Arg         280 285 290 atc tgg caa gga cgc gac gta aaa att gtc caa ggc ttc ggc atg aca 1027 Ile Trp Gln Gly Arg Asp Val Lys Ile Val Gln Gly Phe Gly Met Thr     295 300 305 gaa acc gca ccg ggc gcc tgt atc ctc gag gca aca gac aca agc aca 1075 Glu Thr Ala Pro Gly Ala Cys Ile Leu Glu Ala Thr Asp Thr Ser Thr 310 315 320 325 cac ctt gga acc gca ggt cga gcc cac ttc ttc acc gac atc aaa cta 1123 His Leu Gly Thr Ala Gly Arg Ala His Phe Phe Thr Asp Ile Lys Leu                 330 335 340 gtg gac ccg aaa acc ggc gaa gaa gtc ccc acc gga gag gcc ggc gaa 1171 Val Asp Pro Lys Thr Gly Glu Glu Val Pro Thr Gly Glu Ala Gly Glu             345 350 355 gtt ctc atc cgc gga cca cat gtg atg acc gga tac tgg aac cga cca 1219 Val Leu Ile Arg Gly Pro His Val Met Thr Gly Tyr Trp Asn Arg Pro         360 365 370 gaa gac acc gcc agc gca cta caa aat ggc tgg tac cac tcc gga gat 1267 Glu Asp Thr Ala Ser Ala Leu Gln Asn Gly Trp Tyr His Ser Gly Asp     375 380 385 atc gcc atc aaa gat gaa gac ggc tac tac acc atc aaa gac cgc atc 1315 Ile Ala Ile Lys Asp Glu Asp Gly Tyr Tyr Thr Ile Lys Asp Arg Ile 390 395 400 405 aaa gac atg tac atc tcc ggc ggc gaa aac att tac ccc gca gaa gtc 1363 Lys Asp Met Tyr Ile Ser Gly Gly Glu Asn Ile Tyr Pro Ala Glu Val                 410 415 420 taagtaccc 1372 <210> 88 <211> 421 <212> PRT <213> Corynebacterium glutamicum <400> 88 Met Lys Val Asn Leu Gly Ile Gly Ser Tyr Pro Arg Arg Arg Ala Thr   1 5 10 15 Val Arg Pro Glu Ser Thr Ala Ile Glu Phe Glu Gly Thr Ser Ile Thr              20 25 30 Tyr Gly Glu Phe Ser Lys Arg Val Asn Arg Leu Gly His Ala Leu Leu          35 40 45 Asp Leu Gly Val Ala His Gln Asp Arg Val Ala Tyr Val Gly Phe Asn      50 55 60 His Pro Ala Leu Leu Glu Val Phe Phe Ser Thr Asn Leu Ile Gly Ala  65 70 75 80 Thr Pro Val Leu Val Asn Pro Arg Leu Ser Ala Asn Glu Ile Asp Tyr                  85 90 95 Ile Ile Gln Asp Ser Gly Ala Ser Ile Val Phe Tyr Gly Ile Asp Leu             100 105 110 Ile Glu His Ala Thr Tyr Leu Gln Glu Leu His Pro Glu Ile Ile Met         115 120 125 Val Ala Val Glu Gly Asp Glu Gly Pro Gly Leu Arg Arg Lys Ala Leu     130 135 140 Ile Glu Ala Ala Ser Asp Ala Asp Ile Asp Leu Glu Val Ser Asp Asp 145 150 155 160 Asp Leu Val Leu Leu Met Tyr Thr Ser Gly Thr Thr Gly Arg Pro Lys                 165 170 175 Gly Ala Met Leu Ser His Arg Asn Leu Phe Phe Asn Tyr Phe Asn Ala             180 185 190 Leu Leu Ser Gln Glu Ile Glu Gln Gly Ala Val Leu Leu Ser Thr Ala         195 200 205 Pro Leu Phe His Ile Ala Gly Leu Asn Met Thr Thr Ile Pro Val Met     210 215 220 Met Lys Gly Gly Lys Val Ile Ile His Arg Glu Phe Arg Ala Glu His 225 230 235 240 Val Leu Asp Glu Ile Glu Arg Ser Lys Val Ser Glu Ser Phe Met Val                 245 250 255 Pro Ala Met Ile Asp Met Leu Ser Asn His Pro Ser Phe Ala Glu Arg             260 265 270 Asp Leu Ser Ser Leu Arg Ala Ile Met Val Gly Gly Ser Pro Leu Ser         275 280 285 Glu Arg Ala Leu Arg Ile Trp Gln Gly Arg Asp Val Lys Ile Val Gln     290 295 300 Gly Phe Gly Met Thr Glu Thr Ala Pro Gly Ala Cys Ile Leu Glu Ala 305 310 315 320 Thr Asp Thr Ser Thr His Leu Gly Thr Ala Gly Arg Ala His Phe Phe                 325 330 335 Thr Asp Ile Lys Leu Val Asp Pro Lys Thr Gly Glu Glu Val Pro Thr             340 345 350 Gly Glu Ala Gly Glu Val Leu Ile Arg Gly Pro His Val Met Thr Gly         355 360 365 Tyr Trp Asn Arg Pro Glu Asp Thr Ala Ser Ala Leu Gln Asn Gly Trp     370 375 380 Tyr His Ser Gly Asp Ile Ala Ile Lys Asp Glu Asp Gly Tyr Tyr Thr 385 390 395 400 Ile Lys Asp Arg Ile Lys Asp Met Tyr Ile Ser Gly Gly Glu Asn Ile                 405 410 415 Tyr Pro Ala Glu Val             420 <210> 89 <211> 867 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (844) <223> RXA00681 <400> 89 aagggcaagg ttgtcattgt tgatccagat gcgccacgca tcgaaggacc cggcgcgcac 60 agccatgcgc actcagtagc agcacatggg gtggatacac atg cct agt cca cgc 115                                             Met Pro Ser Pro Arg                                               1 5 act gtt ctt atc act ggt gcc gct ggc ggt ttg ggt cgg gca ttc gct 163 Thr Val Leu Ile Thr Gly Ala Ala Gly Gly Leu Gly Arg Ala Phe Ala                  10 15 20 gaa ggt ttc gca gcc caa gga gac cgt atc gcg gtg gcg gat atc aat 211 Glu Gly Phe Ala Ala Gln Gly Asp Arg Ile Ala Val Ala Asp Ile Asn              25 30 35 ctg gat ggg gcg caa gag acc gtt gac aag ctg aaa gca ttg ggc gca 259 Leu Asp Gly Ala Gln Glu Thr Val Asp Lys Leu Lys Ala Leu Gly Ala          40 45 50 gat gcc gca gcc ttt gaa gtt gat gtc acg tct ttg gag tcc acc gag 307 Asp Ala Ala Ala Phe Glu Val Asp Val Thr Ser Leu Glu Ser Thr Glu      55 60 65 gcc cta gcc gcc ggt gcc gct gag ttt ggc ggt ggc cga att gat gtc 355 Ala Leu Ala Ala Gly Ala Ala Glu Phe Gly Gly Gly Arg Ile Asp Val  70 75 80 85 ctt att aat aac gca gcg ata tat gcg aca gtg act cgt tca ccg ttt 403 Leu Ile Asn Asn Ala Ala Ile Tyr Ala Thr Val Thr Arg Ser Pro Phe                  90 95 100 gag gat att gac cct gcg gag tgg gat ttg gtc atg gga gtc aat ctc 451 Glu Asp Ile Asp Pro Ala Glu Trp Asp Leu Val Met Gly Val Asn Leu             105 110 115 aaa ggc ccg tgg ttg gtg acg cgt tct gtg agt ccg ttt ttg tcc gat 499 Lys Gly Pro Trp Leu Val Thr Arg Ser Val Ser Pro Phe Leu Ser Asp         120 125 130 aat gcc cgt gtg gtc aat ctt tcc agc gcg act gtg ttt tca gga tct 547 Asn Ala Arg Val Val Asn Leu Ser Ser Ala Thr Val Phe Ser Gly Ser     135 140 145 gca cac tgg gcg cac tac gtg gca tcc aaa ggt ggg gtc att gct tta 595 Ala His Trp Ala His Tyr Val Ala Ser Lys Gly Gly Val Ile Ala Leu 150 155 160 165 acc agg gtg ctt gct aaa gag ctg ggt ggt cgt ggg atc acg gtc aat 643 Thr Arg Val Leu Ala Lys Glu Leu Gly Gly Arg Gly Ile Thr Val Asn                 170 175 180 gcg gtt gcg cct ggg ttt acg ctg act gaa gcc agc ttg gga ctc atg 691 Ala Val Ala Pro Gly Phe Thr Leu Thr Glu Ala Ser Leu Gly Leu Met             185 190 195 gat agc gcg gaa acg tac ggt gtc gat cgc gga tcc atc aag cgc gca 739 Asp Ser Ala Glu Thr Tyr Gly Val Asp Arg Gly Ser Ile Lys Arg Ala         200 205 210 agc caa ccg aaa gac atc gtc ggc acc acc atg ttt ctt gca tcc cca 787 Ser Gln Pro Lys Asp Ile Val Gly Thr Thr Met Phe Leu Ala Ser Pro     215 220 225 gaa gcc gaa tac atc act ggg caa aca ctc atc gtt gat ggt ggc cga 835 Glu Ala Glu Tyr Ile Thr Gly Gln Thr Leu Ile Val Asp Gly Gly Arg 230 235 240 245 cag ttc atc taagtactaa aagttctaag gag 867 Gln phe ile <210> 90 <211> 248 <212> PRT <213> Corynebacterium glutamicum <400> 90 Met Pro Ser Pro Arg Thr Val Leu Ile Thr Gly Ala Ala Gly Gly Leu   1 5 10 15 Gly Arg Ala Phe Ala Glu Gly Phe Ala Ala Gln Gly Asp Arg Ile Ala              20 25 30 Val Ala Asp Ile Asn Leu Asp Gly Ala Gln Glu Thr Val Asp Lys Leu          35 40 45 Lys Ala Leu Gly Ala Asp Ala Ala Ala Phe Glu Val Asp Val Thr Ser      50 55 60 Leu Glu Ser Thr Glu Ala Leu Ala Ala Gly Ala Ala Glu Phe Gly Gly  65 70 75 80 Gly Arg Ile Asp Val Leu Ile Asn Asn Ala Ala Ile Tyr Ala Thr Val                  85 90 95 Thr Arg Ser Pro Phe Glu Asp Ile Asp Pro Ala Glu Trp Asp Leu Val             100 105 110 Met Gly Val Asn Leu Lys Gly Pro Trp Leu Val Thr Arg Ser Val Ser         115 120 125 Pro Phe Leu Ser Asp Asn Ala Arg Val Val Asn Leu Ser Ser Ala Thr     130 135 140 Val Phe Ser Gly Ser Ala His Trp Ala His Tyr Val Ala Ser Lys Gly 145 150 155 160 Gly Val Ile Ala Leu Thr Arg Val Leu Ala Lys Glu Leu Gly Gly Arg                 165 170 175 Gly Ile Thr Val Asn Ala Val Ala Pro Gly Phe Thr Leu Thr Glu Ala             180 185 190 Ser Leu Gly Leu Met Asp Ser Ala Glu Thr Tyr Gly Val Asp Arg Gly         195 200 205 Ser Ile Lys Arg Ala Ser Gln Pro Lys Asp Ile Val Gly Thr Thr Met     210 215 220 Phe Leu Ala Ser Pro Glu Ala Glu Tyr Ile Thr Gly Gln Thr Leu Ile 225 230 235 240 Val Asp Gly Gly Arg Gln Phe Ile                 245 <210> 91 <211> 837 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (814) <223> RXA00802 <400> 91 gccatggtga tcacaccagt gtgggggctg aggctccaca cttggaggaa tggattaaac 60 gcgggcacta agccccgaac gattagtagg cttgggcacc atg gat ctt aaa ctt 115                                             Met Asp Leu Lys Leu                                               1 5 ggt ggc caa gtc ata ctt gtt gtt ggc ggt gca gga act att ggt tct 163 Gly Gly Gln Val Ile Leu Val Val Gly Gly Ala Gly Thr Ile Gly Ser                  10 15 20 gaa gtt gta aaa ctc tta act gaa gaa ggc gca acc gcg gta gcg gcg 211 Glu Val Val Lys Leu Leu Thr Glu Glu Gly Ala Thr Ala Val Ala Ala              25 30 35 tcg aga agc acg ccc tta tct att gac gct tcg gat gaa gcg tcc gtc 259 Ser Arg Ser Thr Pro Leu Ser Ile Asp Ala Ser Asp Glu Ala Ser Val          40 45 50 cgt gcg ggc att gat cag gtg atc gca gaa cat ggt cgc ctg gat ggg 307 Arg Ala Gly Ile Asp Gln Val Ile Ala Glu His Gly Arg Leu Asp Gly      55 60 65 ctg gtt gtt tct tct gca ccc gct gcg caa acg ctc agc gcg gag aca 355 Leu Val Val Ser Ser Ala Pro Ala Ala Gln Thr Leu Ser Ala Glu Thr  70 75 80 85 gca gat gat ccg gac act gtg ttg gct gct att gaa ggc aaa gcc atc 403 Ala Asp Asp Pro Asp Thr Val Leu Ala Ala Ile Glu Gly Lys Ala Ile                  90 95 100 acg ttt atg aag gct gca acc gtg gcg ctc gag aag atg cgt gag gct 451 Thr Phe Met Lys Ala Ala Thr Val Ala Leu Glu Lys Met Arg Glu Ala             105 110 115 gga cat ggg cgc atc gtt gca ctt tcc ggc atg aac tca tac aaa aca 499 Gly His Gly Arg Ile Val Ala Leu Ser Gly Met Asn Ser Tyr Lys Thr         120 125 130 ttg agt act act gcg tcg gcg cga aat gct gcg ctg aat gtc gtg gtg 547 Leu Ser Thr Thr Ala Ser Ala Arg Asn Ala Ala Leu Asn Val Val Val     135 140 145 aaa aat ttg gcg gat cgt cac gcg ggc acc gga att aca gta aat gcg 595 Lys Asn Leu Ala Asp Arg His Ala Gly Thr Gly Ile Thr Val Asn Ala 150 155 160 165 att agc ccg gga ttc gtg gta gct gag cca gac gct gag gta aac cgc 643 Ile Ser Pro Gly Phe Val Val Ala Glu Pro Asp Ala Glu Val Asn Arg                 170 175 180 gca aat ggt gac acc acg tgg agg agg tcg cgg agg cga tcg cgt ttt 691 Ala Asn Gly Asp Thr Thr Trp Arg Arg Ser Arg Arg Arg Ser Arg Phe             185 190 195 tgt tgt cgc cgc gca ccg cat caa ttt ctg gag aga tta ttt cgg tgg 739 Cys Cys Arg Arg Ala Pro His Gln Phe Leu Glu Arg Leu Phe Arg Trp         200 205 210 gac ata agg cga agg gca tca tcc ttc ctt agc tcg cgt gag ctt ccc 787 Asp Ile Arg Arg Arg Ala Ser Ser Phe Leu Ser Ser Arg Glu Leu Pro     215 220 225 aag cgt aag cac ccc cgt gtg agg gca taacggccgt tctgttaaag 834 Lys Arg Lys His Pro Arg Val Arg Ala 230 235 att 837 <210> 92 <211> 238 <212> PRT <213> Corynebacterium glutamicum <400> 92 Met Asp Leu Lys Leu Gly Gly Gln Val Ile Leu Val Val Gly Gly Ala   1 5 10 15 Gly Thr Ile Gly Ser Glu Val Val Lys Leu Leu Thr Glu Glu Gly Ala              20 25 30 Thr Ala Val Ala Ala Ser Arg Ser Thr Pro Leu Ser Ile Asp Ala Ser          35 40 45 Asp Glu Ala Ser Val Arg Ala Gly Ile Asp Gln Val Ile Ala Glu His      50 55 60 Gly Arg Leu Asp Gly Leu Val Val Ser Ser Ala Pro Ala Ala Gln Thr  65 70 75 80 Leu Ser Ala Glu Thr Ala Asp Asp Pro Asp Thr Val Leu Ala Ala Ile                  85 90 95 Glu Gly Lys Ala Ile Thr Phe Met Lys Ala Ala Thr Val Ala Leu Glu             100 105 110 Lys Met Arg Glu Ala Gly His Gly Arg Ile Val Ala Leu Ser Gly Met         115 120 125 Asn Ser Tyr Lys Thr Leu Ser Thr Thr Ala Ser Ala Arg Asn Ala Ala     130 135 140 Leu Asn Val Val Val Lys Asn Leu Ala Asp Arg His Ala Gly Thr Gly 145 150 155 160 Ile Thr Val Asn Ala Ile Ser Pro Gly Phe Val Val Ala Glu Pro Asp                 165 170 175 Ala Glu Val Asn Arg Ala Asn Gly Asp Thr Thr Trp Arg Arg Ser Arg             180 185 190 Arg Arg Ser Arg Phe Cys Cys Arg Arg Ala Pro His Gln Phe Leu Glu         195 200 205 Arg Leu Phe Arg Trp Asp Ile Arg Arg Arg Ala Ser Ser Phe Leu Ser     210 215 220 Ser Arg Glu Leu Pro Lys Arg Lys His Pro Arg Val Arg Ala 225 230 235 <210> 93 <211> 329 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (306) <223> RXA02133 <400> 93 gaa aac ccc tac att ggc gga gct gga tac aac gca gca aaa ttc ggt 48 Glu Asn Pro Tyr Ile Gly Gly Ala Gly Tyr Asn Ala Ala Lys Phe Gly   1 5 10 15 gta gca gca ttc aac cgt gtg ctt cgc ttg gaa acc cac cag cag acc 96 Val Ala Ala Phe Asn Arg Val Leu Arg Leu Glu Thr His Gln Gln Thr              20 25 30 ctt cgc gta tct gag atc gat cca ggt cga gtt gcc acg gaa gaa ttc 144 Leu Arg Val Ser Glu Ile Asp Pro Gly Arg Val Ala Thr Glu Glu Phe          35 40 45 tcc ctc gtt cgt ttc ggc gga gat aaa gaa cgc gca gaa gca gtc tat 192 Ser Leu Val Arg Phe Gly Gly Asp Lys Glu Arg Ala Glu Ala Val Tyr      50 55 60 gac gac gtc ctc aac ctc acc gct gaa gac atc gca gag tct gtg cgt 240 Asp Asp Val Leu Asn Leu Thr Ala Glu Asp Ile Ala Glu Ser Val Arg  65 70 75 80 tgg gtc gcg agc ctt cca aag cac atg aac att gac cgc atg cgt att 288 Trp Val Ala Ser Leu Pro Lys His Met Asn Ile Asp Arg Met Arg Ile                  85 90 95 aca cct cgc gat cag gtc taaaacccgc actcttttga aat 329 Thr Pro Arg Asp Gln Val             100 <210> 94 <211> 102 <212> PRT <213> Corynebacterium glutamicum <400> 94 Glu Asn Pro Tyr Ile Gly Gly Ala Gly Tyr Asn Ala Ala Lys Phe Gly   1 5 10 15 Val Ala Ala Phe Asn Arg Val Leu Arg Leu Glu Thr His Gln Gln Thr              20 25 30 Leu Arg Val Ser Glu Ile Asp Pro Gly Arg Val Ala Thr Glu Glu Phe          35 40 45 Ser Leu Val Arg Phe Gly Gly Asp Lys Glu Arg Ala Glu Ala Val Tyr      50 55 60 Asp Asp Val Leu Asn Leu Thr Ala Glu Asp Ile Ala Glu Ser Val Arg  65 70 75 80 Trp Val Ala Ser Leu Pro Lys His Met Asn Ile Asp Arg Met Arg Ile                  85 90 95 Thr Pro Arg Asp Gln Val             100 <210> 95 <211> 1347 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (1324) <223> RXN01114 <400> 95 ttcggtggaa gatatccgca agctggtgct gccgcagctt ttagaaacgg ctcaagcaat 60 ttcgacagat ctctctgcac tctaaattaa ggatcaaaaa atg aac cct caa gat 115                                             Met Asn Pro Gln Asp                                               1 5 att gtc atc tgt tcc cca ttg cgc acc cca gtt ggt gct tac ggc gga 163 Ile Val Ile Cys Ser Pro Leu Arg Thr Pro Val Gly Ala Tyr Gly Gly                  10 15 20 tcc ttc acc ggc gtc cct gtt gaa gaa ttg gcc acc acc gtg atc aac 211 Ser Phe Thr Gly Val Pro Val Glu Glu Leu Ala Thr Thr Val Ile Asn              25 30 35 gcg atc gtt gag gca acc ggc atc acc ggc gac gat gtg gac gat ctg 259 Ala Ile Val Glu Ala Thr Gly Ile Thr Gly Asp Asp Val Asp Asp Leu          40 45 50 atc ctc ggc cag gca tcc ccc aac ggt gcg gct cca gca ctg ggc cgt 307 Ile Leu Gly Gln Ala Ser Pro Asn Gly Ala Ala Pro Ala Leu Gly Arg      55 60 65 gtt gtt gct cta gat tcc aag ctt ggc caa aac gtt cca ggc atg cag 355 Val Val Ala Leu Asp Ser Lys Leu Gly Gln Asn Val Pro Gly Met Gln  70 75 80 85 ctt gat cgc cgc tgt ggt tcc ggc ctg cag gca atc gtc acc gct gct 403 Leu Asp Arg Arg Cys Gly Ser Gly Leu Gln Ala Ile Val Thr Ala Ala                  90 95 100 gca cac gtt gca tcc ggc gct gct gat ctg atc atc gca ggt ggc gca 451 Ala His Val Ala Ser Gly Ala Ala Asp Leu Ile Ile Ala Gly Gly Ala             105 110 115 gaa tcc atg agc cgc gtt gag tac acc gtg tcc ggc gat atc cgt tgg 499 Glu Ser Met Ser Arg Val Glu Tyr Thr Val Ser Gly Asp Ile Arg Trp         120 125 130 ggt gtc aag ggc ggc gac atg cag ctt cgt gac cgc ctt gca gaa gca 547 Gly Val Lys Gly Gly Asp Met Gln Leu Arg Asp Arg Leu Ala Glu Ala     135 140 145 cgc gaa acc gct ggc gga cgc aac cac ccg atc cct ggt ggc atg atc 595 Arg Glu Thr Ala Gly Gly Arg Asn His Pro Ile Pro Gly Gly Met Ile 150 155 160 165 gag acc gct gag aac ctg cgt cgc gaa tac ggc atc tcc cgc gag gag 643 Glu Thr Ala Glu Asn Leu Arg Arg Glu Tyr Gly Ile Ser Arg Glu Glu                 170 175 180 cag gac aag atc tcc gca gcg tcc cag cag cgt tgg ggc aag gct gct 691 Gln Asp Lys Ile Ser Ala Ala Ser Gln Gln Arg Trp Gly Lys Ala Ala             185 190 195 gat gcg ggg ctt ttc gac gac gag atc gtg cca gtc acc gtc cct gcc 739 Asp Ala Gly Leu Phe Asp Asp Glu Ile Val Pro Val Thr Val Pro Ala         200 205 210 aag aag cgc ggc cag gag cca acc atc gtt tct cga gac gag cat ggt 787 Lys Lys Arg Gly Gln Glu Pro Thr Ile Val Ser Arg Asp Glu His Gly     215 220 225 cga cca gga aca acc gtc gaa aag ctt gct gct ttg cgc ccc atc atg 835 Arg Pro Gly Thr Thr Val Glu Lys Leu Ala Ala Leu Arg Pro Ile Met 230 235 240 245 ggc cgc cag gat gcg gaa gca acc gtc acc gct ggc aac gcg tcc ggc 883 Gly Arg Gln Asp Ala Glu Ala Thr Val Thr Ala Gly Asn Ala Ser Gly                 250 255 260 caa aat gat ggc gct gct gcc gtc atc gtg acc act cgc gcc aag gcc 931 Gln Asn Asp Gly Ala Ala Ala Val Ile Val Thr Thr Arg Ala Lys Ala             265 270 275 gag gag aag ggc ctg cgc cca gtc atg cgt ttg gct ggc tgg tct gtg 979 Glu Glu Lys Gly Leu Arg Pro Val Met Arg Leu Ala Gly Trp Ser Val         280 285 290 gct gct gtt ccc cca gag acc atg ggt att gga cct gtt cct gcc acc 1027 Ala Ala Val Pro Pro Glu Thr Met Gly Ile Gly Pro Val Pro Ala Thr     295 300 305 aag aag gtc ctg gat cgt ttg ggc ctt acc ctg gag gac atc ggc gcg 1075 Lys Lys Val Leu Asp Arg Leu Gly Leu Thr Leu Glu Asp Ile Gly Ala 310 315 320 325 atc gaa ctc aac gaa gct ttc gca gct cag gca ctg tct gtg ctg aag 1123 Ile Glu Leu Asn Glu Ala Phe Ala Ala Gln Ala Leu Ser Val Leu Lys                 330 335 340 gaa tgg aac att tct tgg gaa gat gag cgc gtc aac cca ctg ggt tcc 1171 Glu Trp Asn Ile Ser Trp Glu Asp Glu Arg Val Asn Pro Leu Gly Ser             345 350 355 ggt att tcc atg gga cac cca gtc ggt gcc acc ggt gct cgc atg gca 1219 Gly Ile Ser Met Gly His Pro Val Gly Ala Thr Gly Ala Arg Met Ala         360 365 370 gta acc ttg gct cac cgc atg cag cgt gaa aac act cag tac gga ctg 1267 Val Thr Leu Ala His Arg Met Gln Arg Glu Asn Thr Gln Tyr Gly Leu     375 380 385 gcc acc atg tgc atc ggt ggc ggc cag ggt ctt gca gct gtc ttt gaa 1315 Ala Thr Met Cys Ile Gly Gly Gly Gln Gly Leu Ala Ala Val Phe Glu 390 395 400 405 aag gag aac taaaaatggc tattttgcac agc 1347 Lys glu asn <210> 96 <211> 408 <212> PRT <213> Corynebacterium glutamicum <400> 96 Met Asn Pro Gln Asp Ile Val Ile Cys Ser Pro Leu Arg Thr Pro Val   1 5 10 15 Gly Ala Tyr Gly Gly Ser Phe Thr Gly Val Pro Val Glu Glu Leu Ala              20 25 30 Thr Thr Val Ile Asn Ala Ile Val Glu Ala Thr Gly Ile Thr Gly Asp          35 40 45 Asp Val Asp Asp Leu Ile Leu Gly Gln Ala Ser Pro Asn Gly Ala Ala      50 55 60 Pro Ala Leu Gly Arg Val Val Ala Leu Asp Ser Lys Leu Gly Gln Asn  65 70 75 80 Val Pro Gly Met Gln Leu Asp Arg Arg Cys Gly Ser Gly Leu Gln Ala                  85 90 95 Ile Val Thr Ala Ala Ala His Val Ala Ser Gly Ala Ala Asp Leu Ile             100 105 110 Ile Ala Gly Gly Ala Glu Ser Met Ser Arg Val Glu Tyr Thr Val Ser         115 120 125 Gly Asp Ile Arg Trp Gly Val Lys Gly Gly Asp Met Gln Leu Arg Asp     130 135 140 Arg Leu Ala Glu Ala Arg Glu Thr Ala Gly Gly Arg Asn His Pro Ile 145 150 155 160 Pro Gly Gly Met Ile Glu Thr Ala Glu Asn Leu Arg Arg Glu Tyr Gly                 165 170 175 Ile Ser Arg Glu Glu Gln Asp Lys Ile Ser Ala Ala Ser Gln Gln Arg             180 185 190 Trp Gly Lys Ala Ala Asp Ala Gly Leu Phe Asp Asp Glu Ile Val Pro         195 200 205 Val Thr Val Pro Ala Lys Lys Arg Gly Gln Glu Pro Thr Ile Val Ser     210 215 220 Arg Asp Glu His Gly Arg Pro Gly Thr Thr Val Val Glu Lys Leu Ala Ala 225 230 235 240 Leu Arg Pro Ile Met Gly Arg Gln Asp Ala Glu Ala Thr Val Thr Ala                 245 250 255 Gly Asn Ala Ser Gly Gln Asn Asp Gly Ala Ala Ala Val Ile Val Thr             260 265 270 Thr Arg Ala Lys Ala Glu Glu Lys Gly Leu Arg Pro Val Met Arg Leu         275 280 285 Ala Gly Trp Ser Val Ala Ala Val Pro Pro Glu Thr Met Gly Ile Gly     290 295 300 Pro Val Pro Ala Thr Lys Lys Val Leu Asp Arg Leu Gly Leu Thr Leu 305 310 315 320 Glu Asp Ile Gly Ala Ile Glu Leu Asn Glu Ala Phe Ala Ala Gln Ala                 325 330 335 Leu Ser Val Leu Lys Glu Trp Asn Ile Ser Trp Glu Asp Glu Arg Val             340 345 350 Asn Pro Leu Gly Ser Gly Ile Ser Met Gly His Pro Val Gly Ala Thr         355 360 365 Gly Ala Arg Met Ala Val Thr Leu Ala His Arg Met Gln Arg Glu Asn     370 375 380 Thr Gln Tyr Gly Leu Ala Thr Met Cys Ile Gly Gly Gly Gln Gly Leu 385 390 395 400 Ala Ala Val Phe Glu Lys Glu Asn                 405 <210> 97 <211> 815 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (792) <223> FRXA01114 <400> 97 cgc ctt gca gaa gca cgc gaa acc gct ggc gga cgc aac cac ccg atc 48 Arg Leu Ala Glu Ala Arg Glu Thr Ala Gly Gly Arg Asn His Pro Ile   1 5 10 15 cct ggt ggc atg atc gag acc gct gag aac ctg cgt cgc gaa tac ggc 96 Pro Gly Gly Met Ile Glu Thr Ala Glu Asn Leu Arg Arg Glu Tyr Gly              20 25 30 atc tcc cgc gag gag cag gac aag atc tcc gca gcg tcc cag cag cgt 144 Ile Ser Arg Glu Glu Gln Asp Lys Ile Ser Ala Ala Ser Gln Gln Arg          35 40 45 tgg ggc aag gct gct gat gcg ggg ctt ttc gac gac gag atc gtg cca 192 Trp Gly Lys Ala Ala Asp Ala Gly Leu Phe Asp Asp Glu Ile Val Pro      50 55 60 gtc acc gtc cct gcc aag aag cgc ggc cag gag cca acc atc gtt tct 240 Val Thr Val Pro Ala Lys Lys Arg Gly Gln Glu Pro Thr Ile Val Ser  65 70 75 80 cga gac gag cat ggt cga cca gga aca acc gtc gaa aag ctt gct gct 288 Arg Asp Glu His Gly Arg Pro Gly Thr Thr Val Val Glu Lys Leu Ala Ala                  85 90 95 ttg cgc ccc atc atg ggc cgc cag gat gcg gaa gca acc gtc acc gct 336 Leu Arg Pro Ile Met Gly Arg Gln Asp Ala Glu Ala Thr Val Thr Ala             100 105 110 ggc aac gcg tcc ggc caa aat gat ggc gct gct gcc gtc atc gtg acc 384 Gly Asn Ala Ser Gly Gln Asn Asp Gly Ala Ala Ala Val Ile Val Thr         115 120 125 act cgc gcc aag gcc gag gag aag ggc ctg cgc cca gtc atg cgt ttg 432 Thr Arg Ala Lys Ala Glu Glu Lys Gly Leu Arg Pro Val Met Arg Leu     130 135 140 gct ggc tgg tct gtg gct gct gtt ccc cca gag acc atg ggt att gga 480 Ala Gly Trp Ser Val Ala Ala Val Pro Pro Glu Thr Met Gly Ile Gly 145 150 155 160 cct gtt cct gcc acc aag aag gtc ctg gat cgt ttg ggc ctt acc ctg 528 Pro Val Pro Ala Thr Lys Lys Val Leu Asp Arg Leu Gly Leu Thr Leu                 165 170 175 gag gac atc ggc gcg atc gaa ctc aac gaa gct ttc gca gct cag gca 576 Glu Asp Ile Gly Ala Ile Glu Leu Asn Glu Ala Phe Ala Ala Gln Ala             180 185 190 ctg tct gtg ctg aag gaa tgg aac att tct tgg gaa gat gag cgc gtc 624 Leu Ser Val Leu Lys Glu Trp Asn Ile Ser Trp Glu Asp Glu Arg Val         195 200 205 aac cca ctg ggt tcc ggt att tcc atg gga cac cca gtc ggt gcc acc 672 Asn Pro Leu Gly Ser Gly Ile Ser Met Gly His Pro Val Gly Ala Thr     210 215 220 ggt gct cgc atg gca gta acc ttg gct cac cgc atg cag cgt gaa aac 720 Gly Ala Arg Met Ala Val Thr Leu Ala His Arg Met Gln Arg Glu Asn 225 230 235 240 act cag tac gga ctg gcc acc atg tgc atc ggt ggc ggc cag ggt ctt 768 Thr Gln Tyr Gly Leu Ala Thr Met Cys Ile Gly Gly Gly Gln Gly Leu                 245 250 255 gca gct gtc ttt gaa aag gag aac taaaaatggc tattttgcac agc 815 Ala Ala Val Phe Glu Lys Glu Asn             260 <210> 98 <211> 264 <212> PRT <213> Corynebacterium glutamicum <400> 98 Arg Leu Ala Glu Ala Arg Glu Thr Ala Gly Gly Arg Asn His Pro Ile   1 5 10 15 Pro Gly Gly Met Ile Glu Thr Ala Glu Asn Leu Arg Arg Glu Tyr Gly              20 25 30 Ile Ser Arg Glu Glu Gln Asp Lys Ile Ser Ala Ala Ser Gln Gln Arg          35 40 45 Trp Gly Lys Ala Ala Asp Ala Gly Leu Phe Asp Asp Glu Ile Val Pro      50 55 60 Val Thr Val Pro Ala Lys Lys Arg Gly Gln Glu Pro Thr Ile Val Ser  65 70 75 80 Arg Asp Glu His Gly Arg Pro Gly Thr Thr Val Val Glu Lys Leu Ala Ala                  85 90 95 Leu Arg Pro Ile Met Gly Arg Gln Asp Ala Glu Ala Thr Val Thr Ala             100 105 110 Gly Asn Ala Ser Gly Gln Asn Asp Gly Ala Ala Ala Val Ile Val Thr         115 120 125 Thr Arg Ala Lys Ala Glu Glu Lys Gly Leu Arg Pro Val Met Arg Leu     130 135 140 Ala Gly Trp Ser Val Ala Ala Val Pro Pro Glu Thr Met Gly Ile Gly 145 150 155 160 Pro Val Pro Ala Thr Lys Lys Val Leu Asp Arg Leu Gly Leu Thr Leu                 165 170 175 Glu Asp Ile Gly Ala Ile Glu Leu Asn Glu Ala Phe Ala Ala Gln Ala             180 185 190 Leu Ser Val Leu Lys Glu Trp Asn Ile Ser Trp Glu Asp Glu Arg Val         195 200 205 Asn Pro Leu Gly Ser Gly Ile Ser Met Gly His Pro Val Gly Ala Thr     210 215 220 Gly Ala Arg Met Ala Val Thr Leu Ala His Arg Met Gln Arg Glu Asn 225 230 235 240 Thr Gln Tyr Gly Leu Ala Thr Met Cys Ile Gly Gly Gly Gln Gly Leu                 245 250 255 Ala Ala Val Phe Glu Lys Glu Asn             260 <210> 99 <211> 978 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (955) <223> RXA01894 <400> 99 agaatttttt cgaaaatgct ggcaccatca acagtgacat tgttagaaac ttcaaggaga 60 acccatgaat gaaccggagc aacatcaccg gtccatgagg atg ccc aaa ccc aaa 115                                             Met Pro Lys Pro Lys                                               1 5 aat aat gcg ggt cga gat ctc aaa gct gcc att gct gtg ggg atc gga 163 Asn Asn Ala Gly Arg Asp Leu Lys Ala Ala Ile Ala Val Gly Ile Gly                  10 15 20 ctg ggg gtc ctg gtt ctt ttg ggg att gtc cta agc cca tgg ggt tgg 211 Leu Gly Val Leu Val Leu Leu Gly Ile Val Leu Ser Pro Trp Gly Trp              25 30 35 tac atc ctc gtt gca ggt ttt atg gct gca gca aca tgg gaa gtt ggt 259 Tyr Ile Leu Val Ala Gly Phe Met Ala Ala Ala Thr Trp Glu Val Gly          40 45 50 agc aga ctt aaa gaa ggc ggc tat cat ttg cca ctg ccg att atg atc 307 Ser Arg Leu Lys Glu Gly Gly Tyr His Leu Pro Leu Pro Ile Met Ile      55 60 65 atc ggc ggt cag gca atc atc tgg ctg tca tgg cca ttt ggc acg atg 355 Ile Gly Gly Gln Ala Ile Ile Trp Leu Ser Trp Pro Phe Gly Thr Met  70 75 80 85 ggc att ttg gcg tct ttt gtg gcc act gtg ttg gtg ctg atg tat ttc 403 Gly Ile Leu Ala Ser Phe Val Ala Thr Val Leu Val Leu Met Tyr Phe                  90 95 100 cga att ttc tac aat ggc acg gaa aaa gaa gcc cgc aac tat ttg agg 451 Arg Ile Phe Tyr Asn Gly Thr Glu Lys Glu Ala Arg Asn Tyr Leu Arg             105 110 115 gac acc tct gtg ggc atc ttc gtg ctc acc tgg att cca ttg ttc gga 499 Asp Thr Ser Val Gly Ile Phe Val Leu Thr Trp Ile Pro Leu Phe Gly         120 125 130 agc ttc gct gcg atg ctg tcg ctg atg caa aac aat tcc atc ccg ggt 547 Ser Phe Ala Ala Met Leu Ser Leu Met Gln Asn Asn Ser Ile Pro Gly     135 140 145 aca tat ttc att ttg acg ttc atg ctg tgt gtg atc gca tcg gat gtg 595 Thr Tyr Phe Ile Leu Thr Phe Met Leu Cys Val Ile Ala Ser Asp Val 150 155 160 165 ggc ggg tat atc gcg ggt gtg ttc ttt gga tcg cac cca atg gcg ccg 643 Gly Gly Tyr Ile Ala Gly Val Phe Phe Gly Ser His Pro Met Ala Pro                 170 175 180 ttg gtg agt ccg aag aag tct tgg gaa ggc ttt gcc ggc tcc att gtc 691 Leu Val Ser Pro Lys Lys Ser Trp Glu Gly Phe Ala Gly Ser Ile Val             185 190 195 tta gga tcg gtc act ggt gca ctc agt gtt cac ttc ctg ctc gat cac 739 Leu Gly Ser Val Thr Gly Ala Leu Ser Val His Phe Leu Leu Asp His         200 205 210 cac tgg tgg atg ggt gtg atc ttg ggt tgt gcc cta gtt gtg tgc gcc 787 His Trp Trp Met Gly Val Ile Leu Gly Cys Ala Leu Val Val Cys Ala     215 220 225 acg ttg ggt gac ttg gtt gag tcg cag ttc aaa cgc gat ttg ggc atc 835 Thr Leu Gly Asp Leu Val Glu Ser Gln Phe Lys Arg Asp Leu Gly Ile 230 235 240 245 aag gat atg tcg aac ctt ctt cca ggc cac ggc gga ttg atg gac cgt 883 Lys Asp Met Ser Asn Leu Leu Pro Gly His Gly Gly Leu Met Asp Arg                 250 255 260 ttg gat ggc atg ctc ccg gcc gcg atg gtg acg tgg ttg atc ctg agt 931 Leu Asp Gly Met Leu Pro Ala Ala Met Val Thr Trp Leu Ile Leu Ser             265 270 275 gtg atc agc agc tcg tat ccg tcg taaagcttgg gccagcttta agt 978 Val Ile Ser Ser Ser Tyr Pro Ser         280 285 <210> 100 <211> 285 <212> PRT <213> Corynebacterium glutamicum <400> 100 Met Pro Lys Pro Lys Asn Asn Ala Gly Arg Asp Leu Lys Ala Ala Ile   1 5 10 15 Ala Val Gly Ile Gly Leu Gly Val Leu Val Leu Leu Gly Ile Val Leu              20 25 30 Ser Pro Trp Gly Trp Tyr Ile Leu Val Ala Gly Phe Met Ala Ala Ala          35 40 45 Thr Trp Glu Val Gly Ser Arg Leu Lys Glu Gly Gly Tyr His Leu Pro      50 55 60 Leu Pro Ile Met Ile Ile Gly Gly Gln Ala Ile Ile Trp Leu Ser Trp  65 70 75 80 Pro Phe Gly Thr Met Gly Ile Leu Ala Ser Phe Val Ala Thr Val Leu                  85 90 95 Val Leu Met Tyr Phe Arg Ile Phe Tyr Asn Gly Thr Glu Lys Glu Ala             100 105 110 Arg Asn Tyr Leu Arg Asp Thr Ser Val Gly Ile Phe Val Leu Thr Trp         115 120 125 Ile Pro Leu Phe Gly Ser Phe Ala Ala Met Leu Ser Leu Met Gln Asn     130 135 140 Asn Ser Ile Pro Gly Thr Tyr Phe Ile Leu Thr Phe Met Leu Cys Val 145 150 155 160 Ile Ala Ser Asp Val Gly Gly Tyr Ile Ala Gly Val Phe Phe Gly Ser                 165 170 175 His Pro Met Ala Pro Leu Val Ser Pro Lys Lys Ser Trp Glu Gly Phe             180 185 190 Ala Gly Ser Ile Val Leu Gly Ser Val Thr Gly Ala Leu Ser Val His         195 200 205 Phe Leu Leu Asp His His Trp Trp Met Gly Val Ile Leu Gly Cys Ala     210 215 220 Leu Val Val Cys Ala Thr Leu Gly Asp Leu Val Glu Ser Gln Phe Lys 225 230 235 240 Arg Asp Leu Gly Ile Lys Asp Met Ser Asn Leu Leu Pro Gly His Gly                 245 250 255 Gly Leu Met Asp Arg Leu Asp Gly Met Leu Pro Ala Ala Met Val Thr             260 265 270 Trp Leu Ile Leu Ser Val Ile Ser Ser Ser Tyr Pro Ser         275 280 285 <210> 101 <211> 600 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (577) <223> RXA02599 <400> 101 gatcaagcat catacgatgt cggagattgt ggcgggcgtt gttacaggag cagttgcaac 60 cggcatttgt tatgcactcc tacttgcgta aaggagaatt atg gat cag cta atc 115                                             Met Asp Gln Leu Ile                                               1 5 ctc gac gca ttt atc ggc ttg aga gtg act tgg ctg agt ccg gtg att 163 Leu Asp Ala Phe Ile Gly Leu Arg Val Thr Trp Leu Ser Pro Val Ile                  10 15 20 att ttg ttc acc cag ctc acc ggg cca aca ctg atg ttt gtg tat gcg 211 Ile Leu Phe Thr Gln Leu Thr Gly Pro Thr Leu Met Phe Val Tyr Ala              25 30 35 ctt gtg tgg ggc ttg ttg cgc aag agc gcc act gcc ccg atc gcg gtg 259 Leu Val Trp Gly Leu Leu Arg Lys Ser Ala Thr Ala Pro Ile Ala Val          40 45 50 ggg ctg gct aat ctg atc agt cat ttt ctc aag agg gcg ttt gaa cgg 307 Gly Leu Ala Asn Leu Ile Ser His Phe Leu Lys Arg Ala Phe Glu Arg      55 60 65 cct cga cca aat aca gca gag cac ttg gtt gta gaa act aac ttt tca 355 Pro Arg Pro Asn Thr Ala Glu His Leu Val Val Glu Thr Asn Phe Ser  70 75 80 85 ttc cct tct ggt cat gct gtg ggc gct gca gca tgt gcc gtg gca gtg 403 Phe Pro Ser Gly His Ala Val Gly Ala Ala Ala Cys Ala Val Ala Val                  90 95 100 ggg tac tcc gtg aac cgg tgg tgg aaa ctc acg ctg tgg gta atc gcg 451 Gly Tyr Ser Val Asn Arg Trp Trp Lys Leu Thr Leu Trp Val Ile Ala             105 110 115 ctg ctt gtg ggg ctg tct cgg ttg tat gtc ggt gtg cat tgg ccc agc 499 Leu Leu Val Gly Leu Ser Arg Leu Tyr Val Gly Val His Trp Pro Ser         120 125 130 gat gtg ctt gcc ggc tgg gcc atc ggt gcg ttg act tca gtg gtg gtg 547 Asp Val Leu Ala Gly Trp Ala Ile Gly Ala Leu Thr Ser Val Val Val     135 140 145 ttt acc agc tgg aac ctc ctc cag cgc cgc tgaaaccact gctgaaagtg 597 Phe Thr Ser Trp Asn Leu Leu Gln Arg Arg 150 155 gta 600 <210> 102 <211> 159 <212> PRT <213> Corynebacterium glutamicum <400> 102 Met Asp Gln Leu Ile Leu Asp Ala Phe Ile Gly Leu Arg Val Thr Trp   1 5 10 15 Leu Ser Pro Val Ile Ile Leu Phe Thr Gln Leu Thr Gly Pro Thr Leu              20 25 30 Met Phe Val Tyr Ala Leu Val Trp Gly Leu Leu Arg Lys Ser Ala Thr          35 40 45 Ala Pro Ile Ala Val Gly Leu Ala Asn Leu Ile Ser His Phe Leu Lys      50 55 60 Arg Ala Phe Glu Arg Pro Arg Pro Asn Thr Ala Glu His Leu Val Val  65 70 75 80 Glu Thr Asn Phe Ser Phe Pro Ser Gly His Ala Val Gly Ala Ala Ala                  85 90 95 Cys Ala Val Ala Val Gly Tyr Ser Val Asn Arg Trp Trp Lys Leu Thr             100 105 110 Leu Trp Val Ile Ala Leu Leu Val Gly Leu Ser Arg Leu Tyr Val Gly         115 120 125 Val His Trp Pro Ser Asp Val Leu Ala Gly Trp Ala Ile Gly Ala Leu     130 135 140 Thr Ser Val Val Val Phe Thr Ser Trp Asn Leu Leu Gln Arg Arg 145 150 155 <210> 103 <211> 999 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (976) <223> RXN02638 <400> 103 ctctgttgtt gttcctgagg cgcttcgtcc attcgtgggc aaagacgtgc tcaagccagt 60 gaaacaagcc ggttaattaa gcggaaagct cgtggtcgac atg gtc aaa agg ttt 115                                             Met val lys arg phe                                               1 5 ggc ttt ttc gta gag gat tcc ctg cct aag gtt ccg ctg cat ccc gaa 163 Gly Phe Phe Val Glu Asp Ser Leu Pro Lys Val Pro Leu His Pro Glu                  10 15 20 gag tca cgg gag acg ttt tat ggg cgc atc atc att agt gct gtg cgg 211 Glu Ser Arg Glu Thr Phe Tyr Gly Arg Ile Ile Ile Ser Ala Val Arg              25 30 35 acg gtg atg aaa gcc cag gat gtg cag att tcc atc ttc ggt gcg gag 259 Thr Val Met Lys Ala Gln Asp Val Gln Ile Ser Ile Phe Gly Ala Glu          40 45 50 aac att ccg acc acc ggc ggc gca ctt ttc gca tca acc aca ctg gtt 307 Asn Ile Pro Thr Thr Gly Gly Ala Leu Phe Ala Ser Thr Thr Leu Val      55 60 65 att atg act tca ttc tgg gtg gta tcc ccc gca ttc gtg cgg ggt aag 355 Ile Met Thr Ser Phe Trp Val Val Ser Pro Ala Phe Val Arg Gly Lys  70 75 80 85 cgc ctg gtt cga ttc atg gcg aag aag gaa att ttc gac acc cca gtt 403 Arg Leu Val Arg Phe Met Ala Lys Lys Glu Ile Phe Asp Thr Pro Val                  90 95 100 gtc ggc acc ctc atg cgc tgg atg aag cac gtc tct gtg gac cgc tcc 451 Val Gly Thr Leu Met Arg Trp Met Lys His Val Ser Val Asp Arg Ser             105 110 115 gca ggt gcc ggt tcc atg gaa gat gcg cgg aag cgt ctc gac gcc ggc 499 Ala Gly Ala Gly Ser Met Glu Asp Ala Arg Lys Arg Leu Asp Ala Gly         120 125 130 agc ctc gtc ggt atc ttc cct gag gcg acg gtg tca cgg tcc ttt gaa 547 Ser Leu Val Gly Ile Phe Pro Glu Ala Thr Val Ser Arg Ser Phe Glu     135 140 145 atc aag gaa cta aaa act ggc gcc gtc cgc atc gcc gac agc gct aac 595 Ile Lys Glu Leu Lys Thr Gly Ala Val Arg Ile Ala Asp Ser Ala Asn 150 155 160 165 gtt ccg ctg ctg cca ctt att att tgg ggc ggc cag cgc atc atc acc 643 Val Pro Leu Leu Pro Leu Ile Ile Trp Gly Gly Gln Arg Ile Ile Thr                 170 175 180 aaa gac atc gag cgc gac ttc ggc cgc tcc cac atc ccc gta ttc atc 691 Lys Asp Ile Glu Arg Asp Phe Gly Arg Ser His Ile Pro Val Phe Ile             185 190 195 agc gtg ggt gaa ccc gtc gac gcc agc ggc gat ccc gac gaa gca acg 739 Ser Val Gly Glu Pro Val Asp Ala Ser Gly Asp Pro Asp Glu Ala Thr         200 205 210 gaa cgc ctc tac gag gct atg aaa aag ctt ctc gac gaa acc cgc acc 787 Glu Arg Leu Tyr Glu Ala Met Lys Lys Leu Leu Asp Glu Thr Arg Thr     215 220 225 gcc tac gaa caa aag tat ggc cca ttc gaa ggt gga gaa ttg tgg cgc 835 Ala Tyr Glu Gln Lys Tyr Gly Pro Phe Glu Gly Gly Glu Leu Trp Arg 230 235 240 245 ccg aaa tcc ctc ggc ggc ggc gcc cca acg ttg gag cag gcg aaa atg 883 Pro Lys Ser Leu Gly Gly Gly Ala Pro Thr Leu Glu Gln Ala Lys Met                 250 255 260 ttg gaa atc gcc gaa cgg gaa cgt cga caa gca aaa cgc gcg gca aag 931 Leu Glu Ile Ala Glu Arg Glu Arg Arg Gln Ala Lys Arg Ala Ala Lys             265 270 275 gtc gcc aag aaa cgc acc acc ttt ata agg aaa atc ttt aaa aaa 976 Val Ala Lys Lys Arg Thr Thr Phe Ile Arg Lys Ile Phe Lys Lys         280 285 290 tgattgcact gggttcagcg ccc 999 <210> 104 <211> 292 <212> PRT <213> Corynebacterium glutamicum <400> 104 Met Val Lys Arg Phe Gly Phe Phe Val Glu Asp Ser Leu Pro Lys Val   1 5 10 15 Pro Leu His Pro Glu Glu Ser Arg Glu Thr Phe Tyr Gly Arg Ile Ile              20 25 30 Ile Ser Ala Val Arg Thr Val Met Lys Ala Gln Asp Val Gln Ile Ser          35 40 45 Ile Phe Gly Ala Glu Asn Ile Pro Thr Thr Gly Gly Ala Leu Phe Ala      50 55 60 Ser Thr Thr Leu Val Ile Met Thr Ser Phe Trp Val Val Ser Pro Ala  65 70 75 80 Phe Val Arg Gly Lys Arg Leu Val Arg Phe Met Ala Lys Lys Glu Ile                  85 90 95 Phe Asp Thr Pro Val Val Gly Thr Leu Met Arg Trp Met Lys His Val             100 105 110 Ser Val Asp Arg Ser Ala Gly Ala Gly Ser Met Glu Asp Ala Arg Lys         115 120 125 Arg Leu Asp Ala Gly Ser Leu Val Gly Ile Phe Pro Glu Ala Thr Val     130 135 140 Ser Arg Ser Phe Glu Ile Lys Glu Leu Lys Thr Gly Ala Val Arg Ile 145 150 155 160 Ala Asp Ser Ala Asn Val Pro Leu Leu Pro Leu Ile Ile Trp Gly Gly                 165 170 175 Gln Arg Ile Ile Thr Lys Asp Ile Glu Arg Asp Phe Gly Arg Ser His             180 185 190 Ile Pro Val Phe Ile Ser Val Gly Glu Pro Val Asp Ala Ser Gly Asp         195 200 205 Pro Asp Glu Ala Thr Glu Arg Leu Tyr Glu Ala Met Lys Lys Leu Leu     210 215 220 Asp Glu Thr Arg Thr Ala Tyr Glu Gln Lys Tyr Gly Pro Phe Glu Gly 225 230 235 240 Gly Glu Leu Trp Arg Pro Lys Ser Leu Gly Gly Gly Ala Pro Thr Leu                 245 250 255 Glu Gln Ala Lys Met Leu Glu Ile Ala Glu Arg Glu Arg Arg Gln Ala             260 265 270 Lys Arg Ala Ala Lys Val Ala Lys Lys Arg Thr Thr Phe Ile Arg Lys         275 280 285 Ile Phe Lys Lys     290 <210> 105 <211> 534 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (8) .. (511) <223> FRXA02638 <400> 105 atgaaga atg gcg cgg aag cgt ctt aac gcc ggc agc ctc gtc ggt atc 49         Met Ala Arg Lys Arg Leu Asn Ala Gly Ser Leu Val Gly Ile           1 5 10 ttc cct gag gcg acg gtg tca cgg tcc ttt gaa atc aag gaa cta aaa 97 Phe Pro Glu Ala Thr Val Ser Arg Ser Phe Glu Ile Lys Glu Leu Lys  15 20 25 30 act ggc gcc gtc cgc atc gcc gac agc gct aac gtt ccg ctg ctg cca 145 Thr Gly Ala Val Arg Ile Ala Asp Ser Ala Asn Val Pro Leu Leu Pro                  35 40 45 ctt att att tgg ggc ggc cag cgc atc atc acc aaa gac atc gag cgc 193 Leu Ile Ile Trp Gly Gly Gln Arg Ile Ile Thr Lys Asp Ile Glu Arg              50 55 60 gac ttc ggc cgc tcc cac atc ccc gta ttc atc agc gtg ggt gaa ccc 241 Asp Phe Gly Arg Ser His Ile Pro Val Phe Ile Ser Val Gly Glu Pro          65 70 75 gtc gac gcc agc ggc gat ccc gac gaa gca acg gaa cgc ctc tac gag 289 Val Asp Ala Ser Gly Asp Pro Asp Glu Ala Thr Glu Arg Leu Tyr Glu      80 85 90 gct atg aaa aag ctt ctc gac gaa acc cgc acc gcc tac gaa caa aag 337 Ala Met Lys Lys Leu Leu Asp Glu Thr Arg Thr Ala Tyr Glu Gln Lys  95 100 105 110 tat ggc cca ttc gaa ggt gga gaa ttg tgg cgc ccg aaa tcc ctc ggc 385 Tyr Gly Pro Phe Glu Gly Gly Glu Leu Trp Arg Pro Lys Ser Leu Gly                 115 120 125 ggc ggc gcc cca acg ttg gag cag gcg aaa atg ttg gaa atc gcc gaa 433 Gly Gly Ala Pro Thr Leu Glu Gln Ala Lys Met Leu Glu Ile Ala Glu             130 135 140 cgg gaa cgt cga caa gca aaa cgc gcg gca aag gtc gcc aag aaa cgc 481 Arg Glu Arg Arg Gln Ala Lys Arg Ala Ala Lys Val Ala Lys Lys Arg         145 150 155 acc acc ttt ata agg aaa atc ttt aaa aaa tgattgcact gggttcagcg 531 Thr Thr Phe Ile Arg Lys Ile Phe Lys Lys     160 165 ccc 534 <210> 106 <211> 168 <212> PRT <213> Corynebacterium glutamicum <400> 106 Met Ala Arg Lys Arg Leu Asn Ala Gly Ser Leu Val Gly Ile Phe Pro   1 5 10 15 Glu Ala Thr Val Ser Arg Ser Phe Glu Ile Lys Glu Leu Lys Thr Gly              20 25 30 Ala Val Arg Ile Ala Asp Ser Ala Asn Val Pro Leu Leu Pro Leu Ile          35 40 45 Ile Trp Gly Gly Gln Arg Ile Ile Thr Lys Asp Ile Glu Arg Asp Phe      50 55 60 Gly Arg Ser His Ile Pro Val Phe Ile Ser Val Gly Glu Pro Val Asp  65 70 75 80 Ala Ser Gly Asp Pro Asp Glu Ala Thr Glu Arg Leu Tyr Glu Ala Met                  85 90 95 Lys Lys Leu Leu Asp Glu Thr Arg Thr Ala Tyr Glu Gln Lys Tyr Gly             100 105 110 Pro Phe Glu Gly Gly Glu Leu Trp Arg Pro Lys Ser Leu Gly Gly Gly         115 120 125 Ala Pro Thr Leu Glu Gln Ala Lys Met Leu Glu Ile Ala Glu Arg Glu     130 135 140 Arg Arg Gln Ala Lys Arg Ala Ala Lys Val Ala Lys Lys Arg Thr Thr 145 150 155 160 Phe Ile Arg Lys Ile Phe Lys Lys                 165 <210> 107 <211> 637 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (637) <223> RXA00856 <400> 107 gtttttagga atagagtggg ctcaagcttt gtgacaagtt ttttggagaa atcattacta 60 gtcgtagtct tcaatttggg tgcaggtagg gtggaacacc gtg agt gat gta tca 115                                             Val Ser Asp Val Ser                                               1 5 gca ggc gta aat ggc gca caa gat cca agc aat caa gcg gtc aag cct 163 Ala Gly Val Asn Gly Ala Gln Asp Pro Ser Asn Gln Ala Val Lys Pro                  10 15 20 tcc aac tgg aac ctt ccg aac ttc ttg acc agc ttg cgt atc att gtc 211 Ser Asn Trp Asn Leu Pro Asn Phe Leu Thr Ser Leu Arg Ile Ile Val              25 30 35 atc cct ttg ttt gcg tgg ctt acg ctt aaa ggt gag acg gaa aac aat 259 Ile Pro Leu Phe Ala Trp Leu Thr Leu Lys Gly Glu Thr Glu Asn Asn          40 45 50 gct ttt gcc tgg tgg gcg ttg gtt gtt ttc att ttg ctc atg atc acc 307 Ala Phe Ala Trp Trp Ala Leu Val Val Phe Ile Leu Leu Met Ile Thr      55 60 65 gac aag ctt gac ggc gat att gcg cga gca cgt ggc ctg gtc act gac 355 Asp Lys Leu Asp Gly Asp Ile Ala Arg Ala Arg Gly Leu Val Thr Asp  70 75 80 85 ttt ggc aag atc gcg gat ccg att gcc gat aag gcg ttg atg acc aca 403 Phe Gly Lys Ile Ala Asp Pro Ile Ala Asp Lys Ala Leu Met Thr Thr                  90 95 100 gca ttt gtc tgt ttc aac atc atc ggc att ttg ccc tgg tgg gtc act 451 Ala Phe Val Cys Phe Asn Ile Ile Gly Ile Leu Pro Trp Trp Val Thr             105 110 115 gcg ttg att gtg ctt cga gag ttc ggc att acc atc tgg cgt ttc ttc 499 Ala Leu Ile Val Leu Arg Glu Phe Gly Ile Thr Ile Trp Arg Phe Phe         120 125 130 caa ctg cgc gct gga aat gtt gtg cct gca tca aag ggg ggc aag ctt 547 Gln Leu Arg Ala Gly Asn Val Val Pro Ala Ser Lys Gly Gly Lys Leu     135 140 145 aag act gct ctg cag act gtt gcc gtt gct ctg tat ctg tgc cct ttc 595 Lys Thr Ala Leu Gln Thr Val Ala Val Ala Leu Tyr Leu Cys Pro Phe 150 155 160 165 cca agt tgg atg gat att cca agc cag atc gtc atg tat gca 637 Pro Ser Trp Met Asp Ile Pro Ser Gln Ile Val Met Tyr Ala                 170 175 <210> 108 <211> 179 <212> PRT <213> Corynebacterium glutamicum <400> 108 Val Ser Asp Val Ser Ala Gly Val Asn Gly Ala Gln Asp Pro Ser Asn   1 5 10 15 Gln Ala Val Lys Pro Ser Asn Trp Asn Leu Pro Asn Phe Leu Thr Ser              20 25 30 Leu Arg Ile Ile Val Ile Pro Leu Phe Ala Trp Leu Thr Leu Lys Gly          35 40 45 Glu Thr Glu Asn Asn Ala Phe Ala Trp Trp Ala Leu Val Val Phe Ile      50 55 60 Leu Leu Met Ile Thr Asp Lys Leu Asp Gly Asp Ile Ala Arg Ala Arg  65 70 75 80 Gly Leu Val Thr Asp Phe Gly Lys Ile Ala Asp Pro Ile Ala Asp Lys                  85 90 95 Ala Leu Met Thr Thr Ala Phe Val Cys Phe Asn Ile Gly Ile Leu             100 105 110 Pro Trp Trp Val Thr Ala Leu Ile Val Leu Arg Glu Phe Gly Ile Thr         115 120 125 Ile Trp Arg Phe Phe Gln Leu Arg Ala Gly Asn Val Val Pro Ala Ser     130 135 140 Lys Gly Gly Lys Leu Lys Thr Ala Leu Gln Thr Val Ala Val Ala Leu 145 150 155 160 Tyr Leu Cys Pro Phe Pro Ser Trp Met Asp Ile Pro Ser Gln Ile Val                 165 170 175 Met tyr ala <210> 109 <211> 780 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (757) <223> RXA02511 <400> 109 ccatgcttgc gcaagcatgg ggcaccattg atggggcacc aggcactgtc gacccaacgc 60 tgacttcagc gatccgtacc gcagcaccga aggagcactg atg ctg gga ctt cat 115                                             Met Leu Gly Leu His                                               1 5 gga cgt aag cct gcg cag gtt att gtt gag cct gtt gcc aaa ttg atg 163 Gly Arg Lys Pro Ala Gln Val Ile Val Glu Pro Val Ala Lys Leu Met                  10 15 20 atc aag ttg aag gtg acg cct aat cag ctc acc tta gtc agc gct ggc 211 Ile Lys Leu Lys Val Thr Pro Asn Gln Leu Thr Leu Val Ser Ala Gly              25 30 35 ctc acc gtt ggg gtg gct ttg ctg ctg att cct acg ggg cat ttg att 259 Leu Thr Val Gly Val Ala Leu Leu Leu Ile Pro Thr Gly His Leu Ile          40 45 50 tgg gcg gca gtt ttg acg ggc ctg ttt gcg gct ttc gac atg att gat 307 Trp Ala Ala Val Leu Thr Gly Leu Phe Ala Ala Phe Asp Met Ile Asp      55 60 65 ggc acg gtt gct cgc atg caa ggt ggt ggc acc aaa ttt ggt gcc acc 355 Gly Thr Val Ala Arg Met Gln Gly Gly Gly Thr Lys Phe Gly Ala Thr  70 75 80 85 ttg gat gcc acg tgt gac cgc atc act gat ggt gca cta ttt ggt gcg 403 Leu Asp Ala Thr Cys Asp Arg Ile Thr Asp Gly Ala Leu Phe Gly Ala                  90 95 100 att acc tgg tgg ctg gtg tat tcc tac gat gca cca cag gca ttg gtc 451 Ile Thr Trp Trp Leu Val Tyr Ser Tyr Asp Ala Pro Gln Ala Leu Val             105 110 115 gct gcc tcc ttg gtt tgt ttg gtt gcc tcc cag gtg atc tct tac gtg 499 Ala Ala Ser Leu Val Cys Leu Val Ala Ser Gln Val Ile Ser Tyr Val         120 125 130 aaa gcc agg gga gag gcc tcc gga ttc acc atg gac ggc ggt ctc gtg 547 Lys Ala Arg Gly Glu Ala Ser Gly Phe Thr Met Asp Gly Gly Leu Val     135 140 145 gaa cgc cct gag cgt ctg att gtc agc ctt gtt ggt ttg ggg ctg acc 595 Glu Arg Pro Glu Arg Leu Ile Val Ser Leu Val Gly Leu Gly Leu Thr 150 155 160 165 gga atg ggc gtt cca tat gcc atc gat gtg gca ctg tgg gcc ctt gca 643 Gly Met Gly Val Pro Tyr Ala Ile Asp Val Ala Leu Trp Ala Leu Ala                 170 175 180 gct ggc agt att tac act gtt gtg cag cgc ttg gtc atg gct gga aag 691 Ala Gly Ser Ile Tyr Thr Val Val Gln Arg Leu Val Met Ala Gly Lys             185 190 195 tcc cca ttg gct aag gaa ttt acc aag gca cca gca ggt gcg aag gca 739 Ser Pro Leu Ala Lys Glu Phe Thr Lys Ala Pro Ala Gly Ala Lys Ala         200 205 210 gat tac agc aac acc aaa taaaaattag ccgagggagc atc 780 Asp Tyr Ser Asn Thr Lys     215 <210> 110 <211> 219 <212> PRT <213> Corynebacterium glutamicum <400> 110 Met Leu Gly Leu His Gly Arg Lys Pro Ala Gln Val Ile Val Glu Pro   1 5 10 15 Val Ala Lys Leu Met Ile Lys Leu Lys Val Thr Pro Asn Gln Leu Thr              20 25 30 Leu Val Ser Ala Gly Leu Thr Val Gly Val Ala Leu Leu Leu Ile Pro          35 40 45 Thr Gly His Leu Ile Trp Ala Ala Val Leu Thr Gly Leu Phe Ala Ala      50 55 60 Phe Asp Met Ile Asp Gly Thr Val Ala Arg Met Gln Gly Gly Gly Thr  65 70 75 80 Lys Phe Gly Ala Thr Leu Asp Ala Thr Cys Asp Arg Ile Thr Asp Gly                  85 90 95 Ala Leu Phe Gly Ala Ile Thr Trp Trp Leu Val Tyr Ser Tyr Asp Ala             100 105 110 Pro Gln Ala Leu Val Ala Ala Ser Leu Val Cys Leu Val Ala Ser Gln         115 120 125 Val Ile Ser Tyr Val Lys Ala Arg Gly Glu Ala Ser Gly Phe Thr Met     130 135 140 Asp Gly Gly Leu Val Glu Arg Pro Glu Arg Leu Ile Val Ser Leu Val 145 150 155 160 Gly Leu Gly Leu Thr Gly Met Gly Val Pro Tyr Ala Ile Asp Val Ala                 165 170 175 Leu Trp Ala Leu Ala Ala Gly Ser Ile Tyr Thr Val Val Gln Arg Leu             180 185 190 Val Met Ala Gly Lys Ser Pro Leu Ala Lys Glu Phe Thr Lys Ala Pro         195 200 205 Ala Gly Ala Lys Ala Asp Tyr Ser Asn Thr Lys     210 215 <210> 111 <211> 678 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (655) <223> RXN02836 <400> 111 ccatcactcg gcttcaccgt ctacggtgct gcccgcagga cagagcgccc ccaaaagctc 60 gcttcagacg ggatccaccc cctcgagatg gacgtcaccg atg aca atc gat gaa 115                                             Met Thr Ile Asp Glu                                               1 5 ggc cgt cgc cag ttc gag gtc aat gta ttc ggc gcg atg gcc ctc acc 163 Gly Arg Arg Gln Phe Glu Val Asn Val Phe Gly Ala Met Ala Leu Thr                  10 15 20 cga ctc gtc ctg ccc cac atg cag aaa caa aag tgg ggg acg atc gtg 211 Arg Leu Val Leu Pro His Met Gln Lys Gln Lys Trp Gly Thr Ile Val              25 30 35 aac atc aca tcg atg ggc ggg aag atc tac acg cct ctc ggc ggc tgg 259 Asn Ile Thr Ser Met Gly Gly Lys Ile Tyr Thr Pro Leu Gly Gly Trp          40 45 50 tat cac ggc acc aag ttc gcc ctc gag gcc ctc tcg gac gcc ctc cgc 307 Tyr His Gly Thr Lys Phe Ala Leu Glu Ala Leu Ser Asp Ala Leu Arg      55 60 65 ctg gag gtc gcc cca ttc ggc atc gac gtt gtt gtc atc gaa ccg ggc 355 Leu Glu Val Ala Pro Phe Gly Ile Asp Val Val Val Ile Glu Pro Gly  70 75 80 85 ggc atc gcc acc gag tgg gga gga atc gct gcc gac aat ctc gac gca 403 Gly Ile Ala Thr Glu Trp Gly Gly Ile Ala Ala Asp Asn Leu Asp Ala                  90 95 100 gtg tcg aaa gac agc gca tac aag cgc cag gct gac gca gta tcg aag 451 Val Ser Lys Asp Ser Ala Tyr Lys Arg Gln Ala Asp Ala Val Ser Lys             105 110 115 tcg ttg cga tct gag gcg aac agc aac cgc aac tca cca ccg tcg gtt 499 Ser Leu Arg Ser Glu Ala Asn Ser Asn Arg Asn Ser Pro Pro Ser Val         120 125 130 gtc gcc gat gcg att gga aag gcc gtg acg gca cgt cac ccc aag acc 547 Val Ala Asp Ala Ile Gly Lys Ala Val Thr Ala Arg His Pro Lys Thr     135 140 145 cgc tat gcc atc ggc ttc ggt gcc aaa ccg ctg att gcc tcg cgc aac 595 Arg Tyr Ala Ile Gly Phe Gly Ala Lys Pro Leu Ile Ala Ser Arg Asn 150 155 160 165 atc ctc acc gat cgc cag ttc gac cca gtg atc act cga gcg act ggc 643 Ile Leu Thr Asp Arg Gln Phe Asp Pro Val Ile Thr Arg Ala Thr Gly                 170 175 180 gtc ccc cgc gac tgaccactct tctgcgcccg tca 678 Val Pro Arg Asp             185 <210> 112 <211> 185 <212> PRT <213> Corynebacterium glutamicum <400> 112 Met Thr Ile Asp Glu Gly Arg Arg Gln Phe Glu Val Asn Val Phe Gly   1 5 10 15 Ala Met Ala Leu Thr Arg Leu Val Leu Pro His Met Gln Lys Gln Lys              20 25 30 Trp Gly Thr Ile Val Asn Ile Thr Ser Met Gly Gly Lys Ile Tyr Thr          35 40 45 Pro Leu Gly Gly Trp Tyr His Gly Thr Lys Phe Ala Leu Glu Ala Leu      50 55 60 Ser Asp Ala Leu Arg Leu Glu Val Ala Pro Phe Gly Ile Asp Val Val  65 70 75 80 Val Ile Glu Pro Gly Gly Ile Ala Thr Glu Trp Gly Gly Ile Ala Ala                  85 90 95 Asp Asn Leu Asp Ala Val Ser Lys Asp Ser Ala Tyr Lys Arg Gln Ala             100 105 110 Asp Ala Val Ser Lys Ser Leu Arg Ser Glu Ala Asn Ser Asn Arg Asn         115 120 125 Ser Pro Pro Ser Val Val Ala Asp Ala Ile Gly Lys Ala Val Thr Ala     130 135 140 Arg His Pro Lys Thr Arg Tyr Ala Ile Gly Phe Gly Ala Lys Pro Leu 145 150 155 160 Ile Ala Ser Arg Asn Ile Leu Thr Asp Arg Gln Phe Asp Pro Val Ile                 165 170 175 Thr Arg Ala Thr Gly Val Pro Arg Asp             180 185 <210> 113 <211> 406 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (406) <223> FRXA02836 <400> 113 ccatcactcg gcttcaccgt ctacggtgct gcccgcagga cagagcgccc ccaaaagctc 60 gcttcagacg ggatccaccc cctcgagatg gacgtcaccg atg aca atc gat gaa 115                                             Met Thr Ile Asp Glu                                               1 5 ggc cgt cgc cag ttc gag gtc aat gta ttc ggc gcg atg gcc ctc acc 163 Gly Arg Arg Gln Phe Glu Val Asn Val Phe Gly Ala Met Ala Leu Thr                  10 15 20 cga ctc gtc ctg ccc cac atg cag aaa caa aag tgg ggg acg atc gtg 211 Arg Leu Val Leu Pro His Met Gln Lys Gln Lys Trp Gly Thr Ile Val              25 30 35 aac atc aca tcg atg ggc ggg aag atc tac acg cct ctc ggc ggc tgg 259 Asn Ile Thr Ser Met Gly Gly Lys Ile Tyr Thr Pro Leu Gly Gly Trp          40 45 50 tat cac ggc acc aag ttc gcc ctc gag gcc ctc tcg gac gcc ctc cgc 307 Tyr His Gly Thr Lys Phe Ala Leu Glu Ala Leu Ser Asp Ala Leu Arg      55 60 65 ctg gag gtc gcc cca ttc ggc atc gac gtt gtt gtc atc gaa ccg ggc 355 Leu Glu Val Ala Pro Phe Gly Ile Asp Val Val Val Ile Glu Pro Gly  70 75 80 85 ggc atc gcc acc gag tgg gga gga atc gct gcc gac aat ctc gac gca 403 Gly Ile Ala Thr Glu Trp Gly Gly Ile Ala Ala Asp Asn Leu Asp Ala                  90 95 100 gtg 406 Val <210> 114 <211> 102 <212> PRT <213> Corynebacterium glutamicum <400> 114 Met Thr Ile Asp Glu Gly Arg Arg Gln Phe Glu Val Asn Val Phe Gly   1 5 10 15 Ala Met Ala Leu Thr Arg Leu Val Leu Pro His Met Gln Lys Gln Lys              20 25 30 Trp Gly Thr Ile Val Asn Ile Thr Ser Met Gly Gly Lys Ile Tyr Thr          35 40 45 Pro Leu Gly Gly Trp Tyr His Gly Thr Lys Phe Ala Leu Glu Ala Leu      50 55 60 Ser Asp Ala Leu Arg Leu Glu Val Ala Pro Phe Gly Ile Asp Val Val  65 70 75 80 Val Ile Glu Pro Gly Gly Ile Ala Thr Glu Trp Gly Gly Ile Ala Ala                  85 90 95 Asp Asn Leu Asp Ala Val             100 <210> 115 <211> 1227 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (1204) <223> RXA02578 <400> 115 ggcaaaaatg aggaacagca cgcccgcaat aatgaggacc gttgcagatc gcttcataaa 60 aacagcccac acctttccgc taaactcgca tgttgaaata atg tct acc caa tca 115                                             Met Ser Thr Gln Ser                                               1 5 tat gca ccc atc cgc cat cgc gga ttc atc agc tca ctc gag gga cta 163 Tyr Ala Pro Ile Arg His Arg Gly Phe Ile Ser Ser Leu Glu Gly Leu                  10 15 20 cgc gca atc gcc tcc ctg gga gtc ttg gcg acc cac gtt gca ttc caa 211 Arg Ala Ile Ala Ser Leu Gly Val Leu Ala Thr His Val Ala Phe Gln              25 30 35 acc tcc gtc gac ccc gcc agc aac atc ggt gca gta ctc gcg cgt ttc 259 Thr Ser Val Asp Pro Ala Ser Asn Ile Gly Ala Val Leu Ala Arg Phe          40 45 50 gac ttt ttc gtc gcc gtc ttc ttc gcc ctc tcc gcc ttc gtt ctt tgg 307 Asp Phe Phe Val Ala Val Phe Phe Ala Leu Ser Ala Phe Val Leu Trp      55 60 65 cga cgc cgc gcc ggg caa cca gtg gga ctg tac tac ctc aaa cgc cta 355 Arg Arg Arg Ala Gly Gln Pro Val Gly Leu Tyr Tyr Leu Lys Arg Leu  70 75 80 85 gcc cgc atc atg ccc gca tac tgg gca acg gtc att gca gtc ctg ctg 403 Ala Arg Ile Met Pro Ala Tyr Trp Ala Thr Val Ile Ala Val Leu Leu                  90 95 100 ttt att ccc acc ggc ccc tgg tta gcc aac ctg acg atg acc caa atc 451 Phe Ile Pro Thr Gly Pro Trp Leu Ala Asn Leu Thr Met Thr Gln Ile             105 110 115 tac tgg cca gac ggg ctc atg aca ggc ctc acc cac ctt tgg tcc ctg 499 Tyr Trp Pro Asp Gly Leu Met Thr Gly Leu Thr His Leu Trp Ser Leu         120 125 130 tgc gtg gaa gtg gcg ttt tac ctg gtg atg ccg ctt ctc gcg tgg gtg 547 Cys Val Glu Val Ala Phe Tyr Leu Val Met Pro Leu Leu Ala Trp Val     135 140 145 ttg gat agg ttt ggt cgg ccg gtg cgc atc ctg ttg att gtt ggt ggg 595 Leu Asp Arg Phe Gly Arg Pro Val Arg Ile Leu Leu Ile Val Gly Gly 150 155 160 165 gca gtg ttg agt ctg gcg tgg ccg tgg att ccc ctt gtg gag cat gcg 643 Ala Val Leu Ser Leu Ala Trp Pro Trp Ile Pro Leu Val Glu His Ala                 170 175 180 ttg gac gag ggg tgg gcg aac atg cag atc tgg cca ccc gct tac gct 691 Leu Asp Glu Gly Trp Ala Asn Met Gln Ile Trp Pro Pro Ala Tyr Ala             185 190 195 tgc tgg ttt gca gtc ggc atg atc gcc gca gaa att gaa gga gtt cga 739 Cys Trp Phe Ala Val Gly Met Ile Ala Ala Glu Ile Glu Gly Val Arg         200 205 210 ttc cca cgg gtt ccg agc ttt gtg tgg gtg ggt tta gct tta gtg gtc 787 Phe Pro Arg Val Pro Ser Phe Val Trp Val Gly Leu Ala Leu Val Val     215 220 225 gct tgg atc gcg ggc caa gaa tgg ttc gga cca cta ggt tta gtg cac 835 Ala Trp Ile Ala Gly Gln Glu Trp Phe Gly Pro Leu Gly Leu Val His 230 235 240 245 ccc agc ccc tgg gaa ttc aac tta aga gtc ctc gcg ggc aca ctt ttc 883 Pro Ser Pro Trp Glu Phe Asn Leu Arg Val Leu Ala Gly Thr Leu Phe                 250 255 260 gct gta ttt ctg gtg gtt ccc tac gcg ctg ggt acg ccc tct cgg ctt 931 Ala Val Phe Leu Val Val Pro Tyr Ala Leu Gly Thr Pro Ser Arg Leu             265 270 275 ctt gat tcc agt tgg atg aaa acg ctc ggc acc tgg tcg tat tcc atc 979 Leu Asp Ser Ser Trp Met Lys Thr Leu Gly Thr Trp Ser Tyr Ser Ile         280 285 290 ttc ctc tgg cac ctt ccc gtg ctg acg att gtg ttc cca ctg ctc ggg 1027 Phe Leu Trp His Leu Pro Val Leu Thr Ile Val Phe Pro Leu Leu Gly     295 300 305 ttg cct tta ttt agt gga aat ttc ctg ttg gtg ttc atc gtg acg gtc 1075 Leu Pro Leu Phe Ser Gly Asn Phe Leu Leu Val Phe Ile Val Thr Val 310 315 320 325 ttg ttg acg atc cca gtt gcc gcc atc agc tac acc ttc atc gaa gag 1123 Leu Leu Thr Ile Pro Val Ala Ala Ile Ser Tyr Thr Phe Ile Glu Glu                 330 335 340 ccc atc agc ggt gga ccc ggc gcg cca ttc agg ctg ggg gtc gtt agg 1171 Pro Ile Ser Gly Gly Pro Gly Ala Pro Phe Arg Leu Gly Val Val Arg             345 350 355 att cac cat ttt tct ggg ggt agg tct gga aaa tgatgaattg gcaccacgtc 1224 Ile His His Phe Ser Gly Gly Arg Ser Gly Lys         360 365 aag 1227 <210> 116 <211> 368 <212> PRT <213> Corynebacterium glutamicum <400> 116 Met Ser Thr Gln Ser Tyr Ala Pro Ile Arg His Arg Gly Phe Ile Ser   1 5 10 15 Ser Leu Glu Gly Leu Arg Ala Ile Ala Ser Leu Gly Val Leu Ala Thr              20 25 30 His Val Ala Phe Gln Thr Ser Val Asp Pro Ala Ser Asn Ile Gly Ala          35 40 45 Val Leu Ala Arg Phe Asp Phe Phe Val Ala Val Phe Phe Ala Leu Ser      50 55 60 Ala Phe Val Leu Trp Arg Arg Arg Ala Gly Gln Pro Val Gly Leu Tyr  65 70 75 80 Tyr Leu Lys Arg Leu Ala Arg Ile Met Pro Ala Tyr Trp Ala Thr Val                  85 90 95 Ile Ala Val Leu Leu Phe Ile Pro Thr Gly Pro Trp Leu Ala Asn Leu             100 105 110 Thr Met Thr Gln Ile Tyr Trp Pro Asp Gly Leu Met Thr Gly Leu Thr         115 120 125 His Leu Trp Ser Leu Cys Val Glu Val Ala Phe Tyr Leu Val Met Pro     130 135 140 Leu Leu Ala Trp Val Leu Asp Arg Phe Gly Arg Pro Val Arg Ile Leu 145 150 155 160 Leu Ile Val Gly Gly Ala Val Leu Ser Leu Ala Trp Pro Trp Ile Pro                 165 170 175 Leu Val Glu His Ala Leu Asp Glu Gly Trp Ala Asn Met Gln Ile Trp             180 185 190 Pro Pro Ala Tyr Ala Cys Trp Phe Ala Val Gly Met Ile Ala Ala Glu         195 200 205 Ile Glu Gly Val Arg Phe Pro Arg Val Pro Ser Phe Val Trp Val Gly     210 215 220 Leu Ala Leu Val Val Ala Trp Ile Ala Gly Gln Glu Trp Phe Gly Pro 225 230 235 240 Leu Gly Leu Val His Pro Ser Pro Trp Glu Phe Asn Leu Arg Val Leu                 245 250 255 Ala Gly Thr Leu Phe Ala Val Phe Leu Val Val Pro Tyr Ala Leu Gly             260 265 270 Thr Pro Ser Arg Leu Leu Asp Ser Ser Trp Met Lys Thr Leu Gly Thr         275 280 285 Trp Ser Tyr Ser Ile Phe Leu Trp His Leu Pro Val Leu Thr Ile Val     290 295 300 Phe Pro Leu Leu Gly Leu Pro Leu Phe Ser Gly Asn Phe Leu Leu Val 305 310 315 320 Phe Ile Val Thr Val Leu Leu Thr Ile Pro Val Ala Ala Ile Ser Tyr                 325 330 335 Thr Phe Ile Glu Glu Pro Ile Ser Gly Gly Pro Gly Ala Pro Phe Arg             340 345 350 Leu Gly Val Val Arg Ile His His Phe Ser Gly Gly Arg Ser Gly Lys         355 360 365 <210> 117 <211> 924 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (901) <223> RXA02150 <400> 117 gtgtttttcg gtgggctgcg atgacgcatg tccaccaaaa gagccacccc ttaaagaaat 60 taaaaagtgg ttttggtagc ttcgcagcaa aatacacatc gtg ggt aac gta ttc 115                                             Val Gly Asn Val Phe                                               1 5 tta gaa gtt cct aca gca gta aag cgc gaa gaa ggg gta aac cca aac 163 Leu Glu Val Pro Thr Ala Val Lys Arg Glu Glu Gly Val Asn Pro Asn                  10 15 20 atc atg aaa aac aac tgg tat cgg ctt ttc aag tat gtg cta att ggc 211 Ile Met Lys Asn Asn Trp Tyr Arg Leu Phe Lys Tyr Val Leu Ile Gly              25 30 35 ccg ttt ttg cgt gtg tac aac cgc ccg gag atc gaa ggc aaa gaa aac 259 Pro Phe Leu Arg Val Tyr Asn Arg Pro Glu Ile Glu Gly Lys Glu Asn          40 45 50 atc cct gca gaa ggt gcc gcg atc atg gcg tcc aac cac gaa gca gtg 307 Ile Pro Ala Glu Gly Ala Ala Ile Met Ala Ser Asn His Glu Ala Val      55 60 65 atg gat tcc ttt tat ttt ccc ctg ctg tgc cca cgg cag ctg acc ttc 355 Met Asp Ser Phe Tyr Phe Pro Leu Leu Cys Pro Arg Gln Leu Thr Phe  70 75 80 85 cca gcg aag gcc gaa tac ttc aca tca cca ggt att aaa ggc aag atg 403 Pro Ala Lys Ala Glu Tyr Phe Thr Ser Pro Gly Ile Lys Gly Lys Met                  90 95 100 cag aag tgg ttt ttt act tct gtg ggg caa gta ccc ctg gac cgc acc 451 Gln Lys Trp Phe Phe Thr Ser Val Gly Gln Val Pro Leu Asp Arg Thr             105 110 115 gca gat aat gcc atg gat tct ttg atg aat acc gcc aaa atg gtg ctg 499 Ala Asp Asn Ala Met Asp Ser Leu Met Asn Thr Ala Lys Met Val Leu         120 125 130 gat cgg gga gac ctc ttc ggt att tac cct gaa gga tct cgt tcg ccc 547 Asp Arg Gly Asp Leu Phe Gly Ile Tyr Pro Glu Gly Ser Arg Ser Pro     135 140 145 gat ggt cgc atc tac aag ggc aaa acc gga atg gcc tat gtt gcg atg 595 Asp Gly Arg Ile Tyr Lys Gly Lys Thr Gly Met Ala Tyr Val Ala Met 150 155 160 165 gaa act ggt acg aca gtt atc ccc gtt gcc atg att ggc agc cgg gac 643 Glu Thr Gly Thr Thr Val Ile Pro Val Ala Met Ile Gly Ser Arg Asp                 170 175 180 gcg aac cct atc gga agt tgg ttt ccg aaa ccc gca aaa gtc agg atc 691 Ala Asn Pro Ile Gly Ser Trp Phe Pro Lys Pro Ala Lys Val Arg Ile             185 190 195 aag gta gga agc cca att gat ccc ctc gca ttc gtc aaa gaa cat ggg 739 Lys Val Gly Ser Pro Ile Asp Pro Leu Ala Phe Val Lys Glu His Gly         200 205 210 ttg aag cct gga acc tac gaa gca gcg cgc aag ctg aca gat cac gtt 787 Leu Lys Pro Gly Thr Tyr Glu Ala Ala Arg Lys Leu Thr Asp His Val     215 220 225 atg ttc att ctt gct gat ctc act ggt cag ccg tat gtt gat gcg tac 835 Met Phe Ile Leu Ala Asp Leu Thr Gly Gln Pro Tyr Val Asp Ala Tyr 230 235 240 245 tct aaa gat gtg aaa aac gct ctg gag gaa gga aaa gga tac ccg gag 883 Ser Lys Asp Val Lys Asn Ala Leu Glu Glu Gly Lys Gly Tyr Pro Glu                 250 255 260 ggc aca gct cct tca cag taatcgggtc ttttctgtta aaa 924 Gly Thr Ala Pro Ser Gln             265 <210> 118 <211> 267 <212> PRT <213> Corynebacterium glutamicum <400> 118 Val Gly Asn Val Phe Leu Glu Val Pro Thr Ala Val Lys Arg Glu Glu   1 5 10 15 Gly Val Asn Pro Asn Ile Met Lys Asn Asn Trp Tyr Arg Leu Phe Lys              20 25 30 Tyr Val Leu Ile Gly Pro Phe Leu Arg Val Tyr Asn Arg Pro Glu Ile          35 40 45 Glu Gly Lys Glu Asn Ile Pro Ala Glu Gly Ala Ala Ile Met Ala Ser      50 55 60 Asn His Glu Ala Val Met Asp Ser Phe Tyr Phe Pro Leu Leu Cys Pro  65 70 75 80 Arg Gln Leu Thr Phe Pro Ala Lys Ala Glu Tyr Phe Thr Ser Pro Gly                  85 90 95 Ile Lys Gly Lys Met Gln Lys Trp Phe Phe Thr Ser Val Gly Gln Val             100 105 110 Pro Leu Asp Arg Thr Ala Asp Asn Ala Met Asp Ser Leu Met Asn Thr         115 120 125 Ala Lys Met Val Leu Asp Arg Gly Asp Leu Phe Gly Ile Tyr Pro Glu     130 135 140 Gly Ser Arg Ser Pro Asp Gly Arg Ile Tyr Lys Gly Lys Thr Gly Met 145 150 155 160 Ala Tyr Val Ala Met Glu Thr Gly Thr Thr Val Ile Pro Val Ala Met                 165 170 175 Ile Gly Ser Arg Asp Ala Asn Pro Ile Gly Ser Trp Phe Pro Lys Pro             180 185 190 Ala Lys Val Arg Ile Lys Val Gly Ser Pro Ile Asp Pro Leu Ala Phe         195 200 205 Val Lys Glu His Gly Leu Lys Pro Gly Thr Tyr Glu Ala Ala Arg Lys     210 215 220 Leu Thr Asp His Val Met Phe Ile Leu Ala Asp Leu Thr Gly Gln Pro 225 230 235 240 Tyr Val Asp Ala Tyr Ser Lys Asp Val Lys Asn Ala Leu Glu Glu Gly                 245 250 255 Lys Gly Tyr Pro Glu Gly Thr Ala Pro Ser Gln             260 265 <210> 119 <211> 504 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (481) <223> RXA00607 <400> 119 cactgccagc aacgccaacg gttgaacccg aaccagaagg cgatgaagac tggcccgaac 60 ccatcaaccc cgcaggcgat aacaaagagg aggcaaaccg atg att ctc gca ctg 115                                             Met Ile Leu Ala Leu                                               1 5 aca gtc gcg ata ctt ttc ggt gga ggt gtc tac ctc att cag caa cgc 163 Thr Val Ala Ile Leu Phe Gly Gly Gly Val Tyr Leu Ile Gln Gln Arg                  10 15 20 gga atg gtg cgc atc gtc ttc ggc atg tca ctg atc ggc cac gca gcg 211 Gly Met Val Arg Ile Val Phe Gly Met Ser Leu Ile Gly His Ala Ala              25 30 35 aac ctg acc atc ctg tac gcc ggt gtg ccc acg tgg cgc ggc gaa gcc 259 Asn Leu Thr Ile Leu Tyr Ala Gly Val Pro Thr Trp Arg Gly Glu Ala          40 45 50 ttc ccc gac agg acc ccg ctt acc gac gcc gcc gat cca ctc ccc cag 307 Phe Pro Asp Arg Thr Pro Leu Thr Asp Ala Ala Asp Pro Leu Pro Gln      55 60 65 gcc ttc gtc ctc acc gcc atc gtc atc gcg atg gcc acc aca acc atc 355 Ala Phe Val Leu Thr Ala Ile Val Ile Ala Met Ala Thr Thr Thr Ile  70 75 80 85 atg ttg gcc ttg gca gca ctg gga cgc agc gac gac acc cgg tcc atc 403 Met Leu Ala Leu Ala Ala Leu Gly Arg Ser Asp Asp Thr Arg Ser Ile                  90 95 100 gaa cca gat gac gat caa tcg cct ttg act act agc gct cgt tca gtc 451 Glu Pro Asp Asp Asp Gln Ser Pro Leu Thr Thr Ser Ala Arg Ser Val             105 110 115 acc aac cca aca gat cag gag gat aaa gct taaatggcca tggatgttct 501 Thr Asn Pro Thr Asp Gln Glu Asp Lys Ala         120 125 cct 504 <210> 120 <211> 127 <212> PRT <213> Corynebacterium glutamicum <400> 120 Met Ile Leu Ala Leu Thr Val Ala Ile Leu Phe Gly Gly Gly Val Tyr   1 5 10 15 Leu Ile Gln Gln Arg Gly Met Val Arg Ile Val Phe Gly Met Ser Leu              20 25 30 Ile Gly His Ala Ala Asn Leu Thr Ile Leu Tyr Ala Gly Val Pro Thr          35 40 45 Trp Arg Gly Glu Ala Phe Pro Asp Arg Thr Pro Leu Thr Asp Ala Ala      50 55 60 Asp Pro Leu Pro Gln Ala Phe Val Leu Thr Ala Ile Val Ile Ala Met  65 70 75 80 Ala Thr Thr Thr Ile Met Leu Ala Leu Ala Ala Leu Gly Arg Ser Asp                  85 90 95 Asp Thr Arg Ser Ile Glu Pro Asp Asp Asp Gln Ser Pro Leu Thr Thr             100 105 110 Ser Ala Arg Ser Val Thr Asn Pro Thr Asp Gln Glu Asp Lys Ala         115 120 125 <210> 121 <211> 1119 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1096) <223> RXA02397 <400> 121 gtgtgaataa aacttgtttc ctggtcattt cccctactga actgcgctta tgcctatgct 60 tagaaaccag agacaagctt aagaaggaca ggggccggcc atg aat gat ttc gaa 115                                             Met Asn Asp Phe Glu                                               1 5 aca acc atc gat cgg atc tct aaa gaa caa gat ccc gca gcc cga agc 163 Thr Thr Ile Asp Arg Ile Ser Lys Glu Gln Asp Pro Ala Ala Arg Ser                  10 15 20 cgc gtg gaa cag ttc att gtg gaa aca gta cgt gca cta ccc aac ttg 211 Arg Val Glu Gln Phe Ile Val Glu Thr Val Arg Ala Leu Pro Asn Leu              25 30 35 acc acc aaa caa ggt gca tcg ttg gct atc caa ctt ctt gat gcg gta 259 Thr Thr Lys Gln Gly Ala Ser Leu Ala Ile Gln Leu Leu Asp Ala Val          40 45 50 cag ctc gcg gat gcg gcg gga acc aag ggg ggt gcg tcg aca agc aat 307 Gln Leu Ala Asp Ala Ala Gly Thr Lys Gly Gly Ala Ser Thr Ser Asn      55 60 65 gct tca tcg ctg cct gac acc ttt gac gcg ctg acc agc ctg att ggc 355 Ala Ser Ser Leu Pro Asp Thr Phe Asp Ala Leu Thr Ser Leu Ile Gly  70 75 80 85 aag ctc gat gtg cgc agc gat tct gaa tgg cgc tcg ttt ggg ttc cag 403 Lys Leu Asp Val Arg Ser Asp Ser Glu Trp Arg Ser Phe Gly Phe Gln                  90 95 100 cct tct gaa act gcg cac ccg cta atg atc gct atc cct gag att gag 451 Pro Ser Glu Thr Ala His Pro Leu Met Ile Ala Ile Pro Glu Ile Glu             105 110 115 att ttt tat cag cac acc gat gtg gag ccg gga agc gat gac gcc gtg 499 Ile Phe Tyr Gln His Thr Asp Val Glu Pro Gly Ser Asp Asp Ala Val         120 125 130 gcg ccg gac ttt cag gaa aat cag gat atg tgg cgc agg cgt ctc gga 547 Ala Pro Asp Phe Gln Glu Asn Gln Asp Met Trp Arg Arg Arg Leu Gly     135 140 145 tct gtc acc gaa cca aac ctt ata tat aaa gag ttt tcc gga ccc ggc 595 Ser Val Thr Glu Pro Asn Leu Ile Tyr Lys Glu Phe Ser Gly Pro Gly 150 155 160 165 aaa gcg cag cgt gcc gta gaa atg ctg ggc aat ctg tgg aag atc ggc 643 Lys Ala Gln Arg Ala Val Glu Met Leu Gly Asn Leu Trp Lys Ile Gly                 170 175 180 gtg gtg gtg agt agg aat acg gaa agt cgc ctt ggg tta act cgt gtg 691 Val Val Val Ser Arg Asn Thr Glu Ser Arg Leu Gly Leu Thr Arg Val             185 190 195 gaa tac acc ccc acc cct ggc gaa gta ccc gtg ccg ctg atg tcg gag 739 Glu Tyr Thr Pro Thr Pro Gly Glu Val Pro Val Pro Leu Met Ser Glu         200 205 210 aag aac tgt tgg tac agc att cgg gtg tct gaa acc att ggt gag aac 787 Lys Asn Cys Trp Tyr Ser Ile Arg Val Ser Glu Thr Ile Gly Glu Asn     215 220 225 cag gtt ccg gaa att gtg cgc tgc tta ggc gag att ttc tgt ggc tat 835 Gln Val Pro Glu Ile Val Arg Cys Leu Gly Glu Ile Phe Cys Gly Tyr 230 235 240 245 ctt ccc cag atg tgg ctc aaa gaa cca gta aag gcc ggc aag ttg cga 883 Leu Pro Gln Met Trp Leu Lys Glu Pro Val Lys Ala Gly Lys Leu Arg                 250 255 260 atc caa gaa tcg gaa gca gca gcg tat atc gcg atg gcg cga cta gat 931 Ile Gln Glu Ser Glu Ala Ala Ala Tyr Ile Ala Met Ala Arg Leu Asp             265 270 275 ctt tcc cca cgc acc ggc aac acc act tgg acc aac agc tat att tcc 979 Leu Ser Pro Arg Thr Gly Asn Thr Thr Trp Thr Asn Ser Tyr Ile Ser         280 285 290 acg cgt cct ctc tcc ccc gct ttt agg tgg gac gtg gtg ctg gag gct 1027 Thr Arg Pro Leu Ser Pro Ala Phe Arg Trp Asp Val Val Leu Glu Ala     295 300 305 tcc cac caa ttg gag aac ctg ctg cgt gga gac aca ggg ccg gtc act 1075 Ser His Gln Leu Glu Asn Leu Leu Arg Gly Asp Thr Gly Pro Val Thr 310 315 320 325 gcc aca caa tcg gca gct ggt taaccaaaag ttcacgtgga gat 1119 Ala Thr Gln Ser Ala Ala Gly                 330 <210> 122 <211> 332 <212> PRT <213> Corynebacterium glutamicum <400> 122 Met Asn Asp Phe Glu Thr Thr Ile Asp Arg Ile Ser Lys Glu Gln Asp   1 5 10 15 Pro Ala Ala Arg Ser Arg Val Glu Gln Phe Ile Val Glu Thr Val Arg              20 25 30 Ala Leu Pro Asn Leu Thr Thr Lys Gln Gly Ala Ser Leu Ala Ile Gln          35 40 45 Leu Leu Asp Ala Val Gln Leu Ala Asp Ala Ala Gly Thr Lys Gly Gly      50 55 60 Ala Ser Thr Ser Asn Ala Ser Ser Leu Pro Asp Thr Phe Asp Ala Leu  65 70 75 80 Thr Ser Leu Ile Gly Lys Leu Asp Val Arg Ser Asp Ser Glu Trp Arg                  85 90 95 Ser Phe Gly Phe Gln Pro Ser Glu Thr Ala His Pro Leu Met Ile Ala             100 105 110 Ile Pro Glu Ile Glu Ile Phe Tyr Gln His Thr Asp Val Glu Pro Gly         115 120 125 Ser Asp Asp Ala Val Ala Pro Asp Phe Gln Glu Asn Gln Asp Met Trp     130 135 140 Arg Arg Arg Leu Gly Ser Val Thr Glu Pro Asn Leu Ile Tyr Lys Glu 145 150 155 160 Phe Ser Gly Pro Gly Lys Ala Gln Arg Ala Val Glu Met Leu Gly Asn                 165 170 175 Leu Trp Lys Ile Gly Val Val Val Ar Arg Asn Thr Glu Ser Arg Leu             180 185 190 Gly Leu Thr Arg Val Glu Tyr Thr Pro Thr Pro Gly Glu Val Pro Val         195 200 205 Pro Leu Met Ser Glu Lys Asn Cys Trp Tyr Ser Ile Arg Val Ser Glu     210 215 220 Thr Ile Gly Glu Asn Gln Val Pro Glu Ile Val Arg Cys Leu Gly Glu 225 230 235 240 Ile Phe Cys Gly Tyr Leu Pro Gln Met Trp Leu Lys Glu Pro Val Lys                 245 250 255 Ala Gly Lys Leu Arg Ile Gln Glu Ser Glu Ala Ala Ala Tyr Ile Ala             260 265 270 Met Ala Arg Leu Asp Leu Ser Pro Arg Thr Gly Asn Thr Thr Trp Thr         275 280 285 Asn Ser Tyr Ile Ser Thr Arg Pro Leu Ser Pro Ala Phe Arg Trp Asp     290 295 300 Val Val Leu Glu Ala Ser His Gln Leu Glu Asn Leu Leu Arg Gly Asp 305 310 315 320 Thr Gly Pro Val Thr Ala Thr Gln Ser Ala Ala Gly                 325 330 <210> 123 <211> 1462 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (101) .. (1462) <223> RXN03110 <400> 123 aatgagtgaa cctgcgcttg aactataccc cctggggtat tactgtagat tctcaatacc 60 ccgaggggta tctagttttt acgttgagaa ggagagctca gtg ctt att gaa cgc 115                                             Val Leu Ile Glu Arg                                               1 5 atc tac gac gaa gac ctt gcg cag gcc agc tat ttc att ggc tgc caa 163 Ile Tyr Asp Glu Asp Leu Ala Gln Ala Ser Tyr Phe Ile Gly Cys Gln                  10 15 20 gcc cac aac acc gca gtc gtg gtt gat ccg cgt cgc gat att gcc gtc 211 Ala His Asn Thr Ala Val Val Val Asp Pro Arg Arg Asp Ile Ala Val              25 30 35 tat ctg gac atg gcc aag aaa aac gga atg gag att gtt gga gtt acc 259 Tyr Leu Asp Met Ala Lys Lys Asn Gly Met Glu Ile Val Gly Val Thr          40 45 50 gaa acc cat atc cat gcg gac tat ttg tca gga acc cgt gag tta gct 307 Glu Thr His Ile His Ala Asp Tyr Leu Ser Gly Thr Arg Glu Leu Ala      55 60 65 gct gca act aat gcc acc atg tac gtc tca ggg gag ggc ggc gcc gat 355 Ala Ala Thr Asn Ala Thr Met Tyr Val Ser Gly Glu Gly Gly Ala Asp  70 75 80 85 tgg cag tat gaa ttc gac gcc gag cga ata tgc gac ggc agc gag att 403 Trp Gln Tyr Glu Phe Asp Ala Glu Arg Ile Cys Asp Gly Ser Glu Ile                  90 95 100 cgc ctg gga aat ctg gtg ctc aca gct gtt cac acc cca ggc cat acc 451 Arg Leu Gly Asn Leu Val Leu Thr Ala Val His Thr Pro Gly His Thr             105 110 115 ccg gaa cac tta tcg ttc ctg ctg aag gac ggc gcg ttc gca gat gag 499 Pro Glu His Leu Ser Phe Leu Leu Lys Asp Gly Ala Phe Ala Asp Glu         120 125 130 cca gga ttc atg ctc act ggc gat ttc gtt ttc gcg ggt gat ctt ggc 547 Pro Gly Phe Met Leu Thr Gly Asp Phe Val Phe Ala Gly Asp Leu Gly     135 140 145 cga cca gat ttg ctc gat gaa gca gct ggg gga gtg gac act cgt ttt 595 Arg Pro Asp Leu Leu Asp Glu Ala Ala Gly Gly Val Asp Thr Arg Phe 150 155 160 165 gag ggg gct cgc caa atg ttc aag agc ttg aag gaa aaa ttc ctg aca 643 Glu Gly Ala Arg Gln Met Phe Lys Ser Leu Lys Glu Lys Phe Leu Thr                 170 175 180 ttg cct gat cac atc cag atc ttc cct ggt cat ggt tcc ggt tcc gcg 691 Leu Pro Asp His Ile Gln Ile Phe Pro Gly His Gly Ser Gly Ser Ala             185 190 195 tgt ggc aaa gcc ttg ggt tcg gtt cct tca aca aca ctt gga tat gaa 739 Cys Gly Lys Ala Leu Gly Ser Val Pro Ser Thr Thr Leu Gly Tyr Glu         200 205 210 cgt caa ttt gcg tgg tgg gga aag tat ctg gag gca gat gat gaa caa 787 Arg Gln Phe Ala Trp Trp Gly Lys Tyr Leu Glu Ala Asp Asp Glu Gln     215 220 225 gga ttc att gat gag ctt ctg gaa ggc caa cct gat gca cct gca tac 835 Gly Phe Ile Asp Glu Leu Leu Glu Gly Gln Pro Asp Ala Pro Ala Tyr 230 235 240 245 ttc ggc agg atg aag agg caa aat agg caa ggg ccc gca att atg ggc 883 Phe Gly Arg Met Lys Arg Gln Asn Arg Gln Gly Pro Ala Ile Met Gly                 250 255 260 gct cgc gag ctg ttg cca cag ctg gaa gct tct gat ctg cac gac gtc 931 Ala Arg Glu Leu Leu Pro Gln Leu Glu Ala Ser Asp Leu His Asp Val             265 270 275 att gtt gtt gat acc cgc tca gcc gat gaa gtt cac cag ggc act gta 979 Ile Val Val Asp Thr Arg Ser Ala Asp Glu Val His Gln Gly Thr Val         280 285 290 gct ggt gca gtg aat att cct gcg ggc aat tcg atg gcg aaa ttt ggc 1027 Ala Gly Ala Val Asn Ile Pro Ala Gly Asn Ser Met Ala Lys Phe Gly     295 300 305 tcg tgg acc gtt gat ccc gag aag gat tcc cga gct ttg gtt ctg ctc 1075 Ser Trp Thr Val Asp Pro Glu Lys Asp Ser Arg Ala Leu Val Leu Leu 310 315 320 325 gcg gca agc caa att ggt gcc atg gag atg tgg gac cac atg gtt cgc 1123 Ala Ala Ser Gln Ile Gly Ala Met Glu Met Trp Asp His Met Val Arg                 330 335 340 gtg gga atc gat aat gtt gct ggt ttt atc acc aac ttt gat ggg gtg 1171 Val Gly Ile Asp Asn Val Ala Gly Phe Ile Thr Asn Phe Asp Gly Val             345 350 355 gac cta gtt gca ccg caa act gtg tcc cca gat cag ctg gat gaa ttg 1219 Asp Leu Val Ala Pro Gln Thr Val Ser Pro Asp Gln Leu Asp Glu Leu         360 365 370 gaa tac gat cta ctt ctt gat gtc cgc aac cgc agt gaa gtc gaa gaa 1267 Glu Tyr Asp Leu Leu Leu Asp Val Arg Asn Arg Ser Glu Val Glu Glu     375 380 385 ggc tac atc cca gga gca ctc cat att aat ggt gca tcc gtg ctg tgg 1315 Gly Tyr Ile Pro Gly Ala Leu His Ile Asn Gly Ala Ser Val Leu Trp 390 395 400 405 aat ctg gag aaa ctg cca cgt gac gga aag atc gtg agc tac tgc aag 1363 Asn Leu Glu Lys Leu Pro Arg Asp Gly Lys Ile Val Ser Tyr Cys Lys                 410 415 420 agt gga aca cgc agc tca atc gcc gca agc acc ctg cgt aat gct ggt 1411 Ser Gly Thr Arg Ser Ser Ile Ala Ala Ser Thr Leu Arg Asn Ala Gly             425 430 435 ttt gat gtg gtg gaa ctt caa gga tcc tat gac aac tgg gtc cgg cac 1459 Phe Asp Val Val Glu Leu Gln Gly Ser Tyr Asp Asn Trp Val Arg His         440 445 450 aac 1462 Asn <210> 124 <211> 454 <212> PRT <213> Corynebacterium glutamicum <400> 124 Val Leu Ile Glu Arg Ile Tyr Asp Glu Asp Leu Ala Gln Ala Ser Tyr   1 5 10 15 Phe Ile Gly Cys Gln Ala His Asn Thr Ala Val Val Val Asp Pro Arg              20 25 30 Arg Asp Ile Ala Val Tyr Leu Asp Met Ala Lys Lys Asn Gly Met Glu          35 40 45 Ile Val Gly Val Thr Glu Thr His Ile His Ala Asp Tyr Leu Ser Gly      50 55 60 Thr Arg Glu Leu Ala Ala Ala Thr Asn Ala Thr Met Tyr Val Ser Gly  65 70 75 80 Glu Gly Gly Ala Asp Trp Gln Tyr Glu Phe Asp Ala Glu Arg Ile Cys                  85 90 95 Asp Gly Ser Glu Ile Arg Leu Gly Asn Leu Val Leu Thr Ala Val His             100 105 110 Thr Pro Gly His Thr Pro Glu His Leu Ser Phe Leu Leu Lys Asp Gly         115 120 125 Ala Phe Ala Asp Glu Pro Gly Phe Met Leu Thr Gly Asp Phe Val Phe     130 135 140 Ala Gly Asp Leu Gly Arg Pro Asp Leu Leu Asp Glu Ala Ala Gly Gly 145 150 155 160 Val Asp Thr Arg Phe Glu Gly Ala Arg Gln Met Phe Lys Ser Leu Lys                 165 170 175 Glu Lys Phe Leu Thr Leu Pro Asp His Ile Gln Ile Phe Pro Gly His             180 185 190 Gly Ser Gly Ser Ala Cys Gly Lys Ala Leu Gly Ser Val Pro Ser Thr         195 200 205 Thr Leu Gly Tyr Glu Arg Gln Phe Ala Trp Trp Gly Lys Tyr Leu Glu     210 215 220 Ala Asp Asp Glu Gln Gly Phe Ile Asp Glu Leu Leu Glu Gly Gln Pro 225 230 235 240 Asp Ala Pro Ala Tyr Phe Gly Arg Met Lys Arg Gln Asn Arg Gln Gly                 245 250 255 Pro Ala Ile Met Gly Ala Arg Glu Leu Leu Pro Gln Leu Glu Ala Ser             260 265 270 Asp Leu His Asp Val Ile Val Val Asp Thr Arg Ser Ala Asp Glu Val         275 280 285 His Gln Gly Thr Val Ala Gly Ala Val Asn Ile Pro Ala Gly Asn Ser     290 295 300 Met Ala Lys Phe Gly Ser Trp Thr Val Asp Pro Glu Lys Asp Ser Arg 305 310 315 320 Ala Leu Val Leu Leu Ala Ala Ser Gln Ile Gly Ala Met Glu Met Trp                 325 330 335 Asp His Met Val Arg Val Gly Ile Asp Asn Val Ala Gly Phe Ile Thr             340 345 350 Asn Phe Asp Gly Val Asp Leu Val Ala Pro Gln Thr Val Ser Pro Asp         355 360 365 Gln Leu Asp Glu Leu Glu Tyr Asp Leu Leu Leu Asp Val Arg Asn Arg     370 375 380 Ser Glu Val Glu Glu Gly Tyr Ile Pro Gly Ala Leu His Ile Asn Gly 385 390 395 400 Ala Ser Val Leu Trp Asn Leu Glu Lys Leu Pro Arg Asp Gly Lys Ile                 405 410 415 Val Ser Tyr Cys Lys Ser Gly Thr Arg Ser Ser Ile Ala Ala Ser Thr             420 425 430 Leu Arg Asn Ala Gly Phe Asp Val Val Glu Leu Gln Gly Ser Tyr Asp         435 440 445 Asn Trp Val Arg His Asn     450 <210> 125 <211> 1023 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (1023) <223> FRXA00660 <400> 125 cca ggc cat acc ccg gaa cac tta tcg ttc ctg ctg aag gac ggc gcg 48 Pro Gly His Thr Pro Glu His Leu Ser Phe Leu Leu Lys Asp Gly Ala   1 5 10 15 ttc gca cat gag cca gga ttc atg ctc act ggc gat ttc gtt ttc gcg 96 Phe Ala His Glu Pro Gly Phe Met Leu Thr Gly Asp Phe Val Phe Ala              20 25 30 ggt gat ctt ggc cga cca gat ttg ctc gat gaa gca gct ggg gga gtg 144 Gly Asp Leu Gly Arg Pro Asp Leu Leu Asp Glu Ala Ala Gly Gly Val          35 40 45 gac act cgt ttt gag ggg gct cgc caa atg ttc aag agc ttg aag gaa 192 Asp Thr Arg Phe Glu Gly Ala Arg Gln Met Phe Lys Ser Leu Lys Glu      50 55 60 aaa ttc ctg aca ttg cct gat cac atc cag atc ttc cct ggt cat ggt 240 Lys Phe Leu Thr Leu Pro Asp His Ile Gln Ile Phe Pro Gly His Gly  65 70 75 80 tcc ggt tcc gcg tgt ggc aaa gcc ttg ggt tcg gtt cct tca aca aca 288 Ser Gly Ser Ala Cys Gly Lys Ala Leu Gly Ser Val Pro Ser Thr Thr                  85 90 95 ctt gga tat gaa cgt caa ttt gcg tgg tgg gga aag tat ctg gag gca 336 Leu Gly Tyr Glu Arg Gln Phe Ala Trp Trp Gly Lys Tyr Leu Glu Ala             100 105 110 gat gat gaa caa gga ttc att gat gag ctt ctg gaa ggc caa cct gat 384 Asp Asp Glu Gln Gly Phe Ile Asp Glu Leu Leu Glu Gly Gln Pro Asp         115 120 125 gca cct gca tac ttc ggc agg atg aag agg caa aat agg caa ggg ccc 432 Ala Pro Ala Tyr Phe Gly Arg Met Lys Arg Gln Asn Arg Gln Gly Pro     130 135 140 gca att atg ggc gct cgc gag ctg ttg cca cag ctg gaa gct tct gat 480 Ala Ile Met Gly Ala Arg Glu Leu Leu Pro Gln Leu Glu Ala Ser Asp 145 150 155 160 ctg cac gac gtc att gtt gtt gat acc cgc tca gcc gat gaa gtt cac 528 Leu His Asp Val Ile Val Val Asp Thr Arg Ser Ala Asp Glu Val His                 165 170 175 cag ggc act gta gct ggt gca gtg aat att cct gcg ggc aat tcg atg 576 Gln Gly Thr Val Ala Gly Ala Val Asn Ile Pro Ala Gly Asn Ser Met             180 185 190 gcg aaa ttt ggc tcg tgg acc gtt gat ccc gag aag gat tcc cga gct 624 Ala Lys Phe Gly Ser Trp Thr Val Asp Pro Glu Lys Asp Ser Arg Ala         195 200 205 ttg gtt ctg ctc gcg gca agc caa att ggt gcc atg gag atg tgg gac 672 Leu Val Leu Leu Ala Ala Ser Gln Ile Gly Ala Met Glu Met Trp Asp     210 215 220 cac atg gtt cgc gtg gga atc gat aat gtt gct ggt ttt atc acc aac 720 His Met Val Arg Val Gly Ile Asp Asn Val Ala Gly Phe Ile Thr Asn 225 230 235 240 ttt gat ggg gtg gac cta gtt gca ccg caa act gtg tcc cca gat cag 768 Phe Asp Gly Val Asp Leu Val Ala Pro Gln Thr Val Ser Pro Asp Gln                 245 250 255 ctg gat gaa ttg gaa tac gat cta ctt ctt gat gtc cgc aac cgc agt 816 Leu Asp Glu Leu Glu Tyr Asp Leu Leu Leu Asp Val Arg Asn Arg Ser             260 265 270 gaa gtc gaa gaa ggc tac atc cca gga gca ctc cat att aat ggt gca 864 Glu Val Glu Glu Gly Tyr Ile Pro Gly Ala Leu His Ile Asn Gly Ala         275 280 285 tcc gtg ctg tgg aat ctg gag aaa ctg cca cgt gac gga aag atc gtg 912 Ser Val Leu Trp Asn Leu Glu Lys Leu Pro Arg Asp Gly Lys Ile Val     290 295 300 agc tac tgc aag agt gga aca cgc agc tca atc gcc gca agc acc ctg 960 Ser Tyr Cys Lys Ser Gly Thr Arg Ser Ser Ile Ala Ala Ser Thr Leu 305 310 315 320 cgt aat gct ggt ttt gat gtg gtg gaa ctt caa gga tcc tat gac aac 1008 Arg Asn Ala Gly Phe Asp Val Val Glu Leu Gln Gly Ser Tyr Asp Asn                 325 330 335 tgg gtc cgg cac aac 1023 Trp Val Arg His Asn             340 <210> 126 <211> 341 <212> PRT <213> Corynebacterium glutamicum <400> 126 Pro Gly His Thr Pro Glu His Leu Ser Phe Leu Leu Lys Asp Gly Ala   1 5 10 15 Phe Ala His Glu Pro Gly Phe Met Leu Thr Gly Asp Phe Val Phe Ala              20 25 30 Gly Asp Leu Gly Arg Pro Asp Leu Leu Asp Glu Ala Ala Gly Gly Val          35 40 45 Asp Thr Arg Phe Glu Gly Ala Arg Gln Met Phe Lys Ser Leu Lys Glu      50 55 60 Lys Phe Leu Thr Leu Pro Asp His Ile Gln Ile Phe Pro Gly His Gly  65 70 75 80 Ser Gly Ser Ala Cys Gly Lys Ala Leu Gly Ser Val Pro Ser Thr Thr                  85 90 95 Leu Gly Tyr Glu Arg Gln Phe Ala Trp Trp Gly Lys Tyr Leu Glu Ala             100 105 110 Asp Asp Glu Gln Gly Phe Ile Asp Glu Leu Leu Glu Gly Gln Pro Asp         115 120 125 Ala Pro Ala Tyr Phe Gly Arg Met Lys Arg Gln Asn Arg Gln Gly Pro     130 135 140 Ala Ile Met Gly Ala Arg Glu Leu Leu Pro Gln Leu Glu Ala Ser Asp 145 150 155 160 Leu His Asp Val Ile Val Val Asp Thr Arg Ser Ala Asp Glu Val His                 165 170 175 Gln Gly Thr Val Ala Gly Ala Val Asn Ile Pro Ala Gly Asn Ser Met             180 185 190 Ala Lys Phe Gly Ser Trp Thr Val Asp Pro Glu Lys Asp Ser Arg Ala         195 200 205 Leu Val Leu Leu Ala Ala Ser Gln Ile Gly Ala Met Glu Met Trp Asp     210 215 220 His Met Val Arg Val Gly Ile Asp Asn Val Ala Gly Phe Ile Thr Asn 225 230 235 240 Phe Asp Gly Val Asp Leu Val Ala Pro Gln Thr Val Ser Pro Asp Gln                 245 250 255 Leu Asp Glu Leu Glu Tyr Asp Leu Leu Leu Asp Val Arg Asn Arg Ser             260 265 270 Glu Val Glu Glu Gly Tyr Ile Pro Gly Ala Leu His Ile Asn Gly Ala         275 280 285 Ser Val Leu Trp Asn Leu Glu Lys Leu Pro Arg Asp Gly Lys Ile Val     290 295 300 Ser Tyr Cys Lys Ser Gly Thr Arg Ser Ser Ile Ala Ala Ser Thr Leu 305 310 315 320 Arg Asn Ala Gly Phe Asp Val Val Glu Leu Gln Gly Ser Tyr Asp Asn                 325 330 335 Trp Val Arg His Asn             340 <210> 127 <211> 756 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (733) <223> RXA00801 <400> 127 ggataagttt gtttctgagc gtattggtct tgatgatgtt gaagaggctt tcaacaccat 60 gaaggctggc gacgtgctgc gttctgtggt ggagatctaa atg gct cac gac gga 115                                             Met Ala His Asp Gly                                               1 5 ttg cgc gta gaa aac att gtc acc tca ggc atc ttt gcc ctt gat ggt 163 Leu Arg Val Glu Asn Ile Val Thr Ser Gly Ile Phe Ala Leu Asp Gly                  10 15 20 ggc gaa tgg gaa gtc gac aac aac atc tgg gtt gtg gga aat gat gat 211 Gly Glu Trp Glu Val Asp Asn Asn Ile Trp Val Val Gly Asn Asp Asp              25 30 35 gag gtt ttc atc atc gat gcg gca cac act gca gca ccc atc atc gag 259 Glu Val Phe Ile Ile Asp Ala Ala His Thr Ala Ala Pro Ile Ile Glu          40 45 50 gct gtc ggt gga cgt gct gtg aag ggc att ttg tgc acc cac gca cac 307 Ala Val Gly Gly Arg Ala Val Lys Gly Ile Leu Cys Thr His Ala His      55 60 65 aat gac cac atc act gtc gca cca gag cta tcc aag gaa ttt gat gca 355 Asn Asp His Ile Thr Val Ala Pro Glu Leu Ser Lys Glu Phe Asp Ala  70 75 80 85 cca atc ttc gtg cac cca ggt gac caa atg ctg tgg gag gaa acc cac 403 Pro Ile Phe Val His Pro Gly Asp Gln Met Leu Trp Glu Glu Thr His                  90 95 100 gga aac ctg acc cac gag gat ttg gca gat cag cag aag ttc caa atc 451 Gly Asn Leu Thr His Glu Asp Leu Ala Asp Gln Gln Lys Phe Gln Ile             105 110 115 gct gga act gaa ctg atc gtg ctt aat acc cct gga cac tca cct gga 499 Ala Gly Thr Glu Leu Ile Val Leu Asn Thr Pro Gly His Ser Pro Gly         120 125 130 tcc agc tgc ttc tac ctc cct gaa gca aac gag ctc ttc tct gga gac 547 Ser Ser Cys Phe Tyr Leu Pro Glu Ala Asn Glu Leu Phe Ser Gly Asp     135 140 145 act ttg ttc cag ggt ggg ccg gga gca act ggc cgt aag tac agc tcc 595 Thr Leu Phe Gln Gly Gly Pro Gly Ala Thr Gly Arg Lys Tyr Ser Ser 150 155 160 165 ttt gac acc atc att gag tcc ctc aag acc tca att ttg gat cta cca 643 Phe Asp Thr Ile Ile Glu Ser Leu Lys Thr Ser Ile Leu Asp Leu Pro                 170 175 180 gcg gaa acc acc gtg cgc act ggc cat ggt gat cac acc agt gtg ggg 691 Ala Glu Thr Thr Val Arg Thr Gly His Gly Asp His Thr Ser Val Gly             185 190 195 gct gag gct cca cac ttg gag gaa tgg att aaa cgc ggg cac 733 Ala Glu Ala Pro His Leu Glu Glu Trp Ile Lys Arg Gly His         200 205 210 taagccccga acgattagta ggc 756 <210> 128 <211> 211 <212> PRT <213> Corynebacterium glutamicum <400> 128 Met Ala His Asp Gly Leu Arg Val Glu Asn Ile Val Thr Ser Gly Ile   1 5 10 15 Phe Ala Leu Asp Gly Gly Glu Trp Glu Val Asp Asn Asn Ile Trp Val              20 25 30 Val Gly Asn Asp Asp Glu Val Phe Ile Ile Asp Ala Ala His Thr Ala          35 40 45 Ala Pro Ile Ile Glu Ala Val Gly Gly Arg Ala Val Lys Gly Ile Leu      50 55 60 Cys Thr His Ala His Asn Asp His Ile Thr Val Ala Pro Glu Leu Ser  65 70 75 80 Lys Glu Phe Asp Ala Pro Ile Phe Val His Pro Gly Asp Gln Met Leu                  85 90 95 Trp Glu Glu Thr His Gly Asn Leu Thr His Glu Asp Leu Ala Asp Gln             100 105 110 Gln Lys Phe Gln Ile Ala Gly Thr Glu Leu Ile Val Leu Asn Thr Pro         115 120 125 Gly His Ser Pro Gly Ser Ser Cys Phe Tyr Leu Pro Glu Ala Asn Glu     130 135 140 Leu Phe Ser Gly Asp Thr Leu Phe Gln Gly Gly Pro Gly Ala Thr Gly 145 150 155 160 Arg Lys Tyr Ser Ser Phe Asp Thr Ile Ile Glu Ser Leu Lys Thr Ser                 165 170 175 Ile Leu Asp Leu Pro Ala Glu Thr Thr Val Arg Thr Gly His Gly Asp             180 185 190 His Thr Ser Val Gly Ala Glu Ala Pro His Leu Glu Glu Trp Ile Lys         195 200 205 Arg Gly His     210 <210> 129 <211> 966 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (943) <223> RXA00821 <400> 129 ttaaaagctt gcttctcgac gcaaaaaccc atccggcgca tcccttcaat gttaggggtg 60 cgctgctatt tttctcccca gttctacgaa atgacttatt gtg act aag ctt gag 115                                             Val Thr Lys Leu Glu                                               1 5 cgc atg gag cat cct gct tac agc caa ttg cgg ccg gtt acc ccg tcc 163 Arg Met Glu His Pro Ala Tyr Ser Gln Leu Arg Pro Val Thr Pro Ser                  10 15 20 gca tct gtt gtt ttg tgc cct aat ccc ggt tac agc tcg ctg gaa ggc 211 Ala Ser Val Val Leu Cys Pro Asn Pro Gly Tyr Ser Ser Leu Glu Gly              25 30 35 act aat tct tgg gtt atc cgg gca cca gaa gac ccc cgg agc att gtc 259 Thr Asn Ser Trp Val Ile Arg Ala Pro Glu Asp Pro Arg Ser Ile Val          40 45 50 atc gat cca ggt cct gaa gat gag ggc cac ctt aac gtc ttg cat tcc 307 Ile Asp Pro Gly Pro Glu Asp Glu Gly His Leu Asn Val Leu His Ser      55 60 65 aag gct gag gag gtg ggt ttg att ctt ctg acc cac cgt cac tat gat 355 Lys Ala Glu Glu Val Gly Leu Ile Leu Leu Thr His Arg His Tyr Asp  70 75 80 85 cat gct gac ggc gca cag cgt ttc cgt cag ctg acc aat gca cct gtg 403 His Ala Asp Gly Ala Gln Arg Phe Arg Gln Leu Thr Asn Ala Pro Val                  90 95 100 cgt gcg atg gac cct tcg tac tgt gct ggt gcg gag gag att cat gat 451 Arg Ala Met Asp Pro Ser Tyr Cys Ala Gly Ala Glu Glu Ile His Asp             105 110 115 ggt gag atc atc acg atc gac ggt gtc acc cca cag att gag gtg gtg 499 Gly Glu Ile Ile Thr Ile Asp Gly Val Thr Pro Gln Ile Glu Val Val         120 125 130 gcc aca cct ggt cat acc cgt gat tct gtg tct tat ttc atc tgg agt 547 Ala Thr Pro Gly His Thr Arg Asp Ser Val Ser Tyr Phe Ile Trp Ser     135 140 145 gga gtc cct cat gag tcc act ttg gag ggc atc gtt tct ggc gac acc 595 Gly Val Pro His Glu Ser Thr Leu Glu Gly Ile Val Ser Gly Asp Thr 150 155 160 165 att gcg ggt cgt cac acc acg atg att tca gag acc gac ggc gat ttg 643 Ile Ala Gly Arg His Thr Thr Met Ile Ser Glu Thr Asp Gly Asp Leu                 170 175 180 ggt gag tac ctg aat tct ttg gcc att ttg gag gag cgc ggc aag gat 691 Gly Glu Tyr Leu Asn Ser Leu Ala Ile Leu Glu Glu Arg Gly Lys Asp             185 190 195 att ccg ctg ctt cca gga cat ggt cca gat gga cag gac gtg tcc tcc 739 Ile Pro Leu Leu Pro Gly His Gly Pro Asp Gly Gln Asp Val Ser Ser         200 205 210 ttc gcg cgt aag tac att gag cgt cgt gag ctg cgt ctg aac cag atc 787 Phe Ala Arg Lys Tyr Ile Glu Arg Arg Glu Leu Arg Leu Asn Gln Ile     215 220 225 cgt gag gta tgg gag acc cgt ggc cgt gac gtg tcc atg aag gat ctc 835 Arg Glu Val Trp Glu Thr Arg Gly Arg Asp Val Ser Met Lys Asp Leu 230 235 240 245 atc gac gcc atc tac gat gat gtt gat cca gtt ctg cgt ggt gca gcc 883 Ile Asp Ala Ile Tyr Asp Asp Val Asp Pro Val Leu Arg Gly Ala Ala                 250 255 260 gag cag tcc act cat gtg gct att cgt tac ctg cag gct cag gaa gct 931 Glu Gln Ser Thr His Val Ala Ile Arg Tyr Leu Gln Ala Gln Glu Ala             265 270 275 tcc gcc tca aac taaacacttt taactaaaca aca 966 Ser Ala Ser Asn         280 <210> 130 <211> 281 <212> PRT <213> Corynebacterium glutamicum <400> 130 Val Thr Lys Leu Glu Arg Met Glu His Pro Ala Tyr Ser Gln Leu Arg   1 5 10 15 Pro Val Thr Pro Ser Ala Ser Val Val Leu Cys Pro Asn Pro Gly Tyr              20 25 30 Ser Ser Leu Glu Gly Thr Asn Ser Trp Val Ile Arg Ala Pro Glu Asp          35 40 45 Pro Arg Ser Ile Val Ile Asp Pro Gly Pro Glu Asp Glu Gly His Leu      50 55 60 Asn Val Leu His Ser Lys Ala Glu Glu Val Gly Leu Ile Leu Leu Thr  65 70 75 80 His Arg His Tyr Asp His Ala Asp Gly Ala Gln Arg Phe Arg Gln Leu                  85 90 95 Thr Asn Ala Pro Val Arg Ala Met Asp Pro Ser Tyr Cys Ala Gly Ala             100 105 110 Glu Glu Ile His Asp Gly Glu Ile Ile Thr Ile Asp Gly Val Thr Pro         115 120 125 Gln Ile Glu Val Val Ala Thr Pro Gly His Thr Arg Asp Ser Val Ser     130 135 140 Tyr Phe Ile Trp Ser Gly Val Pro His Glu Ser Thr Leu Glu Gly Ile 145 150 155 160 Val Ser Gly Asp Thr Ile Ala Gly Arg His Thr Thr Met Ile Ser Glu                 165 170 175 Thr Asp Gly Asp Leu Gly Glu Tyr Leu Asn Ser Leu Ala Ile Leu Glu             180 185 190 Glu Arg Gly Lys Asp Ile Pro Leu Leu Pro Gly His Gly Pro Asp Gly         195 200 205 Gln Asp Val Ser Ser Phe Ala Arg Lys Tyr Ile Glu Arg Arg Glu Leu     210 215 220 Arg Leu Asn Gln Ile Arg Glu Val Trp Glu Thr Arg Gly Arg Asp Val 225 230 235 240 Ser Met Lys Asp Leu Ile Asp Ala Ile Tyr Asp Asp Val Asp Pro Val                 245 250 255 Leu Arg Gly Ala Ala Glu Gln Ser Thr His Val Ala Ile Arg Tyr Leu             260 265 270 Gln Ala Gln Glu Ala Ser Ala Ser Asn         275 280 <210> 131 <211> 1530 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1507) <223> RXN02966 <400> 131 aaatataccc cccagggtat cttgacagat taaagctcga tgttttaggc tctacatata 60 cccccacggg tatcccctca actttgatct aaggtgtcac atg ctt ttt gaa cgc 115                                             Met Leu Phe Glu Arg                                               1 5 atc tac gaa gaa ggc ctc gcc caa gcc agc tat ttc att ggc tgc caa 163 Ile Tyr Glu Glu Gly Leu Ala Gln Ala Ser Tyr Phe Ile Gly Cys Gln                  10 15 20 cgc gaa ggc aaa gcg att gtt gtt gat gct cgc cga gat atc cag acc 211 Arg Glu Gly Lys Ala Ile Val Val Asp Ala Arg Arg Asp Ile Gln Thr              25 30 35 tat ctg gac ctt gca gca aaa aac aac atg gtc att agc gcc gta acc 259 Tyr Leu Asp Leu Ala Ala Lys Asn Asn Met Val Ile Ser Ala Val Thr          40 45 50 gaa acc cat att cat gcc gat tat ctc tcc ggt act cgc gaa ctt gca 307 Glu Thr His Ile His Ala Asp Tyr Leu Ser Gly Thr Arg Glu Leu Ala      55 60 65 gct gcc acc ggc gcc gag att ttc ctc tct ggc gaa ggc gga gct gat 355 Ala Ala Thr Gly Ala Glu Ile Phe Leu Ser Gly Glu Gly Gly Ala Asp  70 75 80 85 tgg caa tat ggc ttt aca ggc acc acc ttg atg cac aat tcc acc atc 403 Trp Gln Tyr Gly Phe Thr Gly Thr Thr Leu Met His Asn Ser Thr Ile                  90 95 100 aag ctg gga aat atc acc atc aca gcc aag cac act ccc gga cac act 451 Lys Leu Gly Asn Ile Thr Ile Thr Ala Lys His Thr Pro Gly His Thr             105 110 115 cca gag cac ctg tca ttt ttg att act gat ggt gcg gtc tca aag gat 499 Pro Glu His Leu Ser Phe Leu Ile Thr Asp Gly Ala Val Ser Lys Asp         120 125 130 ccc ggt ttt atg ctc agc ggt gac ttc gtc ttc gta ggt gac gtg gga 547 Pro Gly Phe Met Leu Ser Gly Asp Phe Val Phe Val Gly Asp Val Gly     135 140 145 cgt cca gat tta ctt gat gag gca gct ggc ggc gtg gac acc cgc ttc 595 Arg Pro Asp Leu Leu Asp Glu Ala Ala Gly Gly Val Asp Thr Arg Phe 150 155 160 165 gcc gga gca cag caa ctc ttc cat agc cta aaa gag cag ttc ctt gca 643 Ala Gly Ala Gln Gln Leu Phe His Ser Leu Lys Glu Gln Phe Leu Ala                 170 175 180 ctc ccc gac cac att cag gtt tat cca ggt cat ggt gct ggc agc cct 691 Leu Pro Asp His Ile Gln Val Tyr Pro Gly His Gly Ala Gly Ser Pro             185 190 195 tgt ggc aag gca ttg ggc gcg atc cct agc acc acc gtg gga tat gaa 739 Cys Gly Lys Ala Leu Gly Ala Ile Pro Ser Thr Thr Val Gly Tyr Glu         200 205 210 aag gct aat gcg tgg tgg gct cca tat ctg cgc agt gat gat gaa gcc 787 Lys Ala Asn Ala Trp Trp Ala Pro Tyr Leu Arg Ser Asp Asp Glu Ala     215 220 225 ggc ttt gtg gaa gag ctt ctc gac ggc cag cca gat gcc cac gct tac 835 Gly Phe Val Glu Glu Leu Leu Asp Gly Gln Pro Asp Ala His Ala Tyr 230 235 240 245 ttt gct cgc atg aaa aag cag aac aag cag gga cct gca gta ctt agt 883 Phe Ala Arg Met Lys Lys Gln Asn Lys Gln Gly Pro Ala Val Leu Ser                 250 255 260 aca tta tcc ccg ctt gtg aag cta gaa gcc gag gaa gtc gtc gaa aag 931 Thr Leu Ser Pro Leu Val Lys Leu Glu Ala Glu Glu Val Val Glu Lys             265 270 275 ctt ggt tct gaa gca gta ttt gtg gat acc cgc gag caa aac caa gtc 979 Leu Gly Ser Glu Ala Val Phe Val Asp Thr Arg Glu Gln Asn Gln Val         280 285 290 cat ctc gga acc gtt gtt ggg gca ttg aat att ccg cgc ggc gcc aag 1027 His Leu Gly Thr Val Val Gly Ala Leu Asn Ile Pro Arg Gly Ala Lys     295 300 305 gcg tcc aat ttt gcg gcg tgg gtt att gat cct caa aag gat gct cag 1075 Ala Ser Asn Phe Ala Ala Trp Val Ile Asp Pro Gln Lys Asp Ala Gln 310 315 320 325 gac ctt att gtt ttg gct ccg gac gcc aat acc gct gcg gat ttc cgc 1123 Asp Leu Ile Val Leu Ala Pro Asp Ala Asn Thr Ala Ala Asp Phe Arg                 330 335 340 gac gct ttg ctg cgg gtt ggc atc gac act gtg cgt tat ttc acc aac 1171 Asp Ala Leu Leu Arg Val Gly Ile Asp Thr Val Arg Tyr Phe Thr Asn             345 350 355 agt atc gat gga ttg cct acc ttt gtg cca gaa ctc atc tcc ccc gct 1219 Ser Ile Asp Gly Leu Pro Thr Phe Val Pro Glu Leu Ile Ser Pro Ala         360 365 370 gag cta gct gag acc aac tat gac gca ctg att gat atc cgt gca aag 1267 Glu Leu Ala Glu Thr Asn Tyr Asp Ala Leu Ile Asp Ile Arg Ala Lys     375 380 385 tcc gaa ttt gcc gct ggc agc att ccc ggc gcg cag cag ctt tct gga 1315 Ser Glu Phe Ala Ala Gly Ser Ile Pro Gly Ala Gln Gln Leu Ser Gly 390 395 400 405 ggt tcg gcc atg tgg cgc ctc aat gag ctg cct gcg ggt ggc act ttg 1363 Gly Ser Ala Met Trp Arg Leu Asn Glu Leu Pro Ala Gly Gly Thr Leu                 410 415 420 gta acc ttc tgc caa tca gga gcg cga aat acc gtg gta gcc aat gct 1411 Val Thr Phe Cys Gln Ser Gly Ala Arg Asn Thr Val Val Ala Asn Ala             425 430 435 ttg cga cgc gcc gga ttc acc gtt atc gag ctc gag ggc agc tac gcc 1459 Leu Arg Arg Ala Gly Phe Thr Val Ile Glu Leu Glu Gly Ser Tyr Ala         440 445 450 gcg tgg gaa aaa tca gct gcc aat cct aaa aac ttg cag act gcc gtc 1507 Ala Trp Glu Lys Ser Ala Ala Asn Pro Lys Asn Leu Gln Thr Ala Val     455 460 465 tagttttaga tccggcgctg tat 1530 <210> 132 <211> 469 <212> PRT <213> Corynebacterium glutamicum <400> 132 Met Leu Phe Glu Arg Ile Tyr Glu Glu Gly Leu Ala Gln Ala Ser Tyr   1 5 10 15 Phe Ile Gly Cys Gln Arg Glu Gly Lys Ala Ile Val Val Asp Ala Arg              20 25 30 Arg Asp Ile Gln Thr Tyr Leu Asp Leu Ala Ala Lys Asn Asn Met Val          35 40 45 Ile Ser Ala Val Thr Glu Thr His Ile His Ala Asp Tyr Leu Ser Gly      50 55 60 Thr Arg Glu Leu Ala Ala Ala Thr Gly Ala Glu Ile Phe Leu Ser Gly  65 70 75 80 Glu Gly Gly Ala Asp Trp Gln Tyr Gly Phe Thr Gly Thr Thr Leu Met                  85 90 95 His Asn Ser Thr Ile Lys Leu Gly Asn Ile Thr Ile Thr Ala Lys His             100 105 110 Thr Pro Gly His Thr Pro Glu His Leu Ser Phe Leu Ile Thr Asp Gly         115 120 125 Ala Val Ser Lys Asp Pro Gly Phe Met Leu Ser Gly Asp Phe Val Phe     130 135 140 Val Gly Asp Val Gly Arg Pro Asp Leu Leu Asp Glu Ala Ala Gly Gly 145 150 155 160 Val Asp Thr Arg Phe Ala Gly Ala Gln Gln Leu Phe His Ser Leu Lys                 165 170 175 Glu Gln Phe Leu Ala Leu Pro Asp His Ile Gln Val Tyr Pro Gly His             180 185 190 Gly Ala Gly Ser Pro Cys Gly Lys Ala Leu Gly Ala Ile Pro Ser Thr         195 200 205 Thr Val Gly Tyr Glu Lys Ala Asn Ala Trp Trp Ala Pro Tyr Leu Arg     210 215 220 Ser Asp Asp Glu Ala Gly Phe Val Glu Glu Leu Leu Asp Gly Gln Pro 225 230 235 240 Asp Ala His Ala Tyr Phe Ala Arg Met Lys Lys Gln Asn Lys Gln Gly                 245 250 255 Pro Ala Val Leu Ser Thr Leu Ser Pro Leu Val Lys Leu Glu Ala Glu             260 265 270 Glu Val Val Glu Lys Leu Gly Ser Glu Ala Val Phe Val Asp Thr Arg         275 280 285 Glu Gln Asn Gln Val His Leu Gly Thr Val Val Gly Ala Leu Asn Ile     290 295 300 Pro Arg Gly Ala Lys Ala Ser Asn Phe Ala Ala Trp Val Ile Asp Pro 305 310 315 320 Gln Lys Asp Ala Gln Asp Leu Ile Val Leu Ala Pro Asp Ala Asn Thr                 325 330 335 Ala Ala Asp Phe Arg Asp Ala Leu Leu Arg Val Gly Ile Asp Thr Val             340 345 350 Arg Tyr Phe Thr Asn Ser Ile Asp Gly Leu Pro Thr Phe Val Pro Glu         355 360 365 Leu Ile Ser Pro Ala Glu Leu Ala Glu Thr Asn Tyr Asp Ala Leu Ile     370 375 380 Asp Ile Arg Ala Lys Ser Glu Phe Ala Ala Gly Ser Ile Pro Gly Ala 385 390 395 400 Gln Gln Leu Ser Gly Gly Ser Ala Met Trp Arg Leu Asn Glu Leu Pro                 405 410 415 Ala Gly Gly Thr Leu Val Thr Phe Cys Gln Ser Gly Ala Arg Asn Thr             420 425 430 Val Val Ala Asn Ala Leu Arg Arg Ala Gly Phe Thr Val Ile Glu Leu         435 440 445 Glu Gly Ser Tyr Ala Ala Trp Glu Lys Ser Ala Ala Asn Pro Lys Asn     450 455 460 Leu Gln Thr Ala Val 465 <210> 133 <211> 1530 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1507) <223> FRXA01833 <133> 133 aaatataccc cccagggtat cttgacagat taaagctcga tgttttaggc tctacatata 60 cccccacggg tatcccctca actttgatct aaggtgtcac atg ctt ttt gaa cgc 115                                             Met Leu Phe Glu Arg                                               1 5 atc tac gaa gaa ggc ctc gcc caa gcc agc tat ttc att ggc tgc caa 163 Ile Tyr Glu Glu Gly Leu Ala Gln Ala Ser Tyr Phe Ile Gly Cys Gln                  10 15 20 cgc gaa ggc aaa gcg att gtt gtt gat gct cgc cga gat atc cag acc 211 Arg Glu Gly Lys Ala Ile Val Val Asp Ala Arg Arg Asp Ile Gln Thr              25 30 35 tat ctg gac ctt gca gca aaa aac aac atg gtc att agc gcc gta acc 259 Tyr Leu Asp Leu Ala Ala Lys Asn Asn Met Val Ile Ser Ala Val Thr          40 45 50 gaa acc cat att cat gcc gat tat ctc tcc ggt act cgc gaa ctt gca 307 Glu Thr His Ile His Ala Asp Tyr Leu Ser Gly Thr Arg Glu Leu Ala      55 60 65 gct gcc acc ggc gcc gag att ttc ctc tct ggc gaa ggc gga gct gat 355 Ala Ala Thr Gly Ala Glu Ile Phe Leu Ser Gly Glu Gly Gly Ala Asp  70 75 80 85 tgg caa tat ggc ttt aca ggc acc acc ttg atg cac aat tcc acc atc 403 Trp Gln Tyr Gly Phe Thr Gly Thr Thr Leu Met His Asn Ser Thr Ile                  90 95 100 aag ctg gaa aat atc acc atc aca gcc aag cac act ccc gga cac act 451 Lys Leu Glu Asn Ile Thr Ile Thr Ala Lys His Thr Pro Gly His Thr             105 110 115 cca gag cac ctg tca ttt ttg att act gat ggt gcg gtc tca aag gat 499 Pro Glu His Leu Ser Phe Leu Ile Thr Asp Gly Ala Val Ser Lys Asp         120 125 130 ccc ggt ttt atg ctc agc ggt gac ttc gtc ttc gta ggt gac gtg gga 547 Pro Gly Phe Met Leu Ser Gly Asp Phe Val Phe Val Gly Asp Val Gly     135 140 145 cgt cca gat tta ctt gat gag gca gct ggc ggc gtg gac acc cgc ttc 595 Arg Pro Asp Leu Leu Asp Glu Ala Ala Gly Gly Val Asp Thr Arg Phe 150 155 160 165 gcc gga gca cag caa ctc ttc cat agc cta aaa gag cag ttc ctt gca 643 Ala Gly Ala Gln Gln Leu Phe His Ser Leu Lys Glu Gln Phe Leu Ala                 170 175 180 ctc ccc gac cac att cag gtt tat cca ggt cat ggt gct ggc agc cct 691 Leu Pro Asp His Ile Gln Val Tyr Pro Gly His Gly Ala Gly Ser Pro             185 190 195 tgt ggc aag gca ttg ggc gcg atc cct agc acc acc gtg gga tat gaa 739 Cys Gly Lys Ala Leu Gly Ala Ile Pro Ser Thr Thr Val Gly Tyr Glu         200 205 210 aag gct aat gcg tgg tgg gct cca tat ctg cgc agt gat gat gaa gcc 787 Lys Ala Asn Ala Trp Trp Ala Pro Tyr Leu Arg Ser Asp Asp Glu Ala     215 220 225 ggc ttt gtg gaa gag ctt ctc gac ggc cag cca gat gcc cac gct tac 835 Gly Phe Val Glu Glu Leu Leu Asp Gly Gln Pro Asp Ala His Ala Tyr 230 235 240 245 ttt gct cgc atg aaa aag cag aac aag cag gga cct gca gta ctt agt 883 Phe Ala Arg Met Lys Lys Gln Asn Lys Gln Gly Pro Ala Val Leu Ser                 250 255 260 aca tta tcc ccg ctt gtg aag cta gaa gcc gag gaa gtc gtc gaa aag 931 Thr Leu Ser Pro Leu Val Lys Leu Glu Ala Glu Glu Val Val Glu Lys             265 270 275 ctt ggt tct gaa gca gta ttt gtg gat acc cgc gag caa aac caa gtc 979 Leu Gly Ser Glu Ala Val Phe Val Asp Thr Arg Glu Gln Asn Gln Val         280 285 290 cat ctc gga acc gtt gtt ggg gca ttg aat att ccg cgc ggc gcc aag 1027 His Leu Gly Thr Val Val Gly Ala Leu Asn Ile Pro Arg Gly Ala Lys     295 300 305 gcg tcc aat ttt gcg gcg tgg gtt att gat cct caa aag gat gct cag 1075 Ala Ser Asn Phe Ala Ala Trp Val Ile Asp Pro Gln Lys Asp Ala Gln 310 315 320 325 gac ctt att gtt ttg gct ccg gac gcc aat acc gct gcg gat ttc cgc 1123 Asp Leu Ile Val Leu Ala Pro Asp Ala Asn Thr Ala Ala Asp Phe Arg                 330 335 340 gac gct ttg ctg cgg gtt ggc atc gac act gtg cgt tat ttc acc aac 1171 Asp Ala Leu Leu Arg Val Gly Ile Asp Thr Val Arg Tyr Phe Thr Asn             345 350 355 agt atc gat gga ttg cct acc ttt gtg cca gaa ctc atc tcc ccc gct 1219 Ser Ile Asp Gly Leu Pro Thr Phe Val Pro Glu Leu Ile Ser Pro Ala         360 365 370 gag cta gct gag acc aac tat gac gca ctg att gat atc cgt gca aag 1267 Glu Leu Ala Glu Thr Asn Tyr Asp Ala Leu Ile Asp Ile Arg Ala Lys     375 380 385 tcc gaa ttt gcc gct ggc agc att ccc ggc gcg cag cag ctt tct gga 1315 Ser Glu Phe Ala Ala Gly Ser Ile Pro Gly Ala Gln Gln Leu Ser Gly 390 395 400 405 ggt tcg gcc atg tgg cgc ctc aat gag ctg cct gcg ggt ggc act ttg 1363 Gly Ser Ala Met Trp Arg Leu Asn Glu Leu Pro Ala Gly Gly Thr Leu                 410 415 420 gta acc ttc tgc caa tca gga gcg cga aat acc gtg gta gcc aat gct 1411 Val Thr Phe Cys Gln Ser Gly Ala Arg Asn Thr Val Val Ala Asn Ala             425 430 435 ttg cga cgc gcc gga ttc acc gtt atc gag ctc gag ggc agc tac gcc 1459 Leu Arg Arg Ala Gly Phe Thr Val Ile Glu Leu Glu Gly Ser Tyr Ala         440 445 450 gcg tgg gaa aaa tca gct gcc aat cct aaa aac ttg cag act gcc gtc 1507 Ala Trp Glu Lys Ser Ala Ala Asn Pro Lys Asn Leu Gln Thr Ala Val     455 460 465 tagttttaga tccggcgctg tat 1530 <210> 134 <211> 469 <212> PRT <213> Corynebacterium glutamicum <400> 134 Met Leu Phe Glu Arg Ile Tyr Glu Glu Gly Leu Ala Gln Ala Ser Tyr   1 5 10 15 Phe Ile Gly Cys Gln Arg Glu Gly Lys Ala Ile Val Val Asp Ala Arg              20 25 30 Arg Asp Ile Gln Thr Tyr Leu Asp Leu Ala Ala Lys Asn Asn Met Val          35 40 45 Ile Ser Ala Val Thr Glu Thr His Ile His Ala Asp Tyr Leu Ser Gly      50 55 60 Thr Arg Glu Leu Ala Ala Ala Thr Gly Ala Glu Ile Phe Leu Ser Gly  65 70 75 80 Glu Gly Gly Ala Asp Trp Gln Tyr Gly Phe Thr Gly Thr Thr Leu Met                  85 90 95 His Asn Ser Thr Ile Lys Leu Glu Asn Ile Thr Ile Thr Ala Lys His             100 105 110 Thr Pro Gly His Thr Pro Glu His Leu Ser Phe Leu Ile Thr Asp Gly         115 120 125 Ala Val Ser Lys Asp Pro Gly Phe Met Leu Ser Gly Asp Phe Val Phe     130 135 140 Val Gly Asp Val Gly Arg Pro Asp Leu Leu Asp Glu Ala Ala Gly Gly 145 150 155 160 Val Asp Thr Arg Phe Ala Gly Ala Gln Gln Leu Phe His Ser Leu Lys                 165 170 175 Glu Gln Phe Leu Ala Leu Pro Asp His Ile Gln Val Tyr Pro Gly His             180 185 190 Gly Ala Gly Ser Pro Cys Gly Lys Ala Leu Gly Ala Ile Pro Ser Thr         195 200 205 Thr Val Gly Tyr Glu Lys Ala Asn Ala Trp Trp Ala Pro Tyr Leu Arg     210 215 220 Ser Asp Asp Glu Ala Gly Phe Val Glu Glu Leu Leu Asp Gly Gln Pro 225 230 235 240 Asp Ala His Ala Tyr Phe Ala Arg Met Lys Lys Gln Asn Lys Gln Gly                 245 250 255 Pro Ala Val Leu Ser Thr Leu Ser Pro Leu Val Lys Leu Glu Ala Glu             260 265 270 Glu Val Val Glu Lys Leu Gly Ser Glu Ala Val Phe Val Asp Thr Arg         275 280 285 Glu Gln Asn Gln Val His Leu Gly Thr Val Val Gly Ala Leu Asn Ile     290 295 300 Pro Arg Gly Ala Lys Ala Ser Asn Phe Ala Ala Trp Val Ile Asp Pro 305 310 315 320 Gln Lys Asp Ala Gln Asp Leu Ile Val Leu Ala Pro Asp Ala Asn Thr                 325 330 335 Ala Ala Asp Phe Arg Asp Ala Leu Leu Arg Val Gly Ile Asp Thr Val             340 345 350 Arg Tyr Phe Thr Asn Ser Ile Asp Gly Leu Pro Thr Phe Val Pro Glu         355 360 365 Leu Ile Ser Pro Ala Glu Leu Ala Glu Thr Asn Tyr Asp Ala Leu Ile     370 375 380 Asp Ile Arg Ala Lys Ser Glu Phe Ala Ala Gly Ser Ile Pro Gly Ala 385 390 395 400 Gln Gln Leu Ser Gly Gly Ser Ala Met Trp Arg Leu Asn Glu Leu Pro                 405 410 415 Ala Gly Gly Thr Leu Val Thr Phe Cys Gln Ser Gly Ala Arg Asn Thr             420 425 430 Val Val Ala Asn Ala Leu Arg Arg Ala Gly Phe Thr Val Ile Glu Leu         435 440 445 Glu Gly Ser Tyr Ala Ala Trp Glu Lys Ser Ala Ala Asn Pro Lys Asn     450 455 460 Leu Gln Thr Ala Val 465 <210> 135 <211> 675 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (652) <223> RXA01853 <400> 135 gaatgtccaa cgtcaaaaaa attcttttct atcctaaccg tatcttcaca ccttgaggga 60 atgatggggg agcgccgctt acgcactaca ctgtttattc atg gag atc ctc gga 115                                             Met Glu Ile Leu Gly                                               1 5 ttc gcg gct ggt ccg tat aaa aca aat tgc tat gtg gtg cgc ggg gag 163 Phe Ala Ala Gly Pro Tyr Lys Thr Asn Cys Tyr Val Val Arg Gly Glu                  10 15 20 aat gag gtc gcg atc att gat cct ggc atg cat gcc cac gat gat ttg 211 Asn Glu Val Ala Ile Ile Asp Pro Gly Met His Ala His Asp Asp Leu              25 30 35 gtg gaa tac atc acc acg aat aat ttg agc gtg gac aag att gtg ctc 259 Val Glu Tyr Ile Thr Thr Asn Asn Leu Ser Val Asp Lys Ile Val Leu          40 45 50 acc cac gga cac att gat cac acc cgt gat gct ggt gtt gtg gca aag 307 Thr His Gly His Ile Asp His Thr Arg Asp Ala Gly Val Val Ala Lys      55 60 65 cgt ttc aat gcg ccg gtc tat atc cat cct gat gat gcg ttt ttc ctt 355 Arg Phe Asn Ala Pro Val Tyr Ile His Pro Asp Asp Ala Phe Phe Leu  70 75 80 85 gag gtc tac aag gga tct gga aca aag acg gcc atg ctt ttc gac gcc 403 Glu Val Tyr Lys Gly Ser Gly Thr Lys Thr Ala Met Leu Phe Asp Ala                  90 95 100 gac aac atg gtg tcc cct gat cct gag tca ctg cgt gat ctg gtt gat 451 Asp Asn Met Val Ser Pro Asp Pro Glu Ser Leu Arg Asp Leu Val Asp             105 110 115 ggt gag aca atc act ttg gct ggc gaa gaa ttc acg ttg aag cat gca 499 Gly Glu Thr Ile Thr Leu Ala Gly Glu Glu Phe Thr Leu Lys His Ala         120 125 130 cca ggg cat tca cct ggt tgt acg ctg atc gtc ggc aag gaa tac tgc 547 Pro Gly His Ser Pro Gly Cys Thr Leu Ile Val Gly Lys Glu Tyr Cys     135 140 145 ttt agc ggt gat gtg ttg ttc aag ggc tct att ggt cgc act gat ttt 595 Phe Ser Gly Asp Val Leu Phe Lys Gly Ser Ile Gly Arg Thr Asp Phe 150 155 160 165 gag tgg tct gat gca gat gcc atg aat gag tca cta cgc acg gca gtg 643 Glu Trp Ser Asp Ala Asp Ala Met Asn Glu Ser Leu Arg Thr Ala Val                 170 175 180 ctc cca ctt tgatgatgca ttgcagattc ttc 675 Leu Pro Leu <210> 136 <211> 184 <212> PRT <213> Corynebacterium glutamicum <400> 136 Met Glu Ile Leu Gly Phe Ala Ala Gly Pro Tyr Lys Thr Asn Cys Tyr   1 5 10 15 Val Val Arg Gly Glu Asn Glu Val Ala Ile Ile Asp Pro Gly Met His              20 25 30 Ala His Asp Asp Leu Val Glu Tyr Ile Thr Thr Asn Asn Leu Ser Val          35 40 45 Asp Lys Ile Val Leu Thr His Gly His Ile Asp His Thr Arg Asp Ala      50 55 60 Gly Val Val Ala Lys Arg Phe Asn Ala Pro Val Tyr Ile His Pro Asp  65 70 75 80 Asp Ala Phe Phe Leu Glu Val Tyr Lys Gly Ser Gly Thr Lys Thr Ala                  85 90 95 Met Leu Phe Asp Ala Asp Asn Met Val Ser Pro Asp Pro Glu Ser Leu             100 105 110 Arg Asp Leu Val Asp Gly Glu Thr Ile Thr Leu Ala Gly Glu Glu Phe         115 120 125 Thr Leu Lys His Ala Pro Gly His Ser Pro Gly Cys Thr Leu Ile Val     130 135 140 Gly Lys Glu Tyr Cys Phe Ser Gly Asp Val Leu Phe Lys Gly Ser Ile 145 150 155 160 Gly Arg Thr Asp Phe Glu Trp Ser Asp Ala Asp Ala Met Asn Glu Ser                 165 170 175 Leu Arg Thr Ala Val Leu Pro Leu             180 <210> 137 <211> 723 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (700) <223> RXN02424 <400> 137 agccaatgct caactgccct tcaaaatcga tttttgtcgc ttcaaaaaat acaccttcga 60 acatagcatc gaacaaggtg tttccgctag tctgaaccac atg act aac gag ctc 115                                             Met thro asn glu leu                                               1 5 act ctt cac cat att tcc gtg tcc caa atg gac aac aat tgc tac ctt 163 Thr Leu His His Ile Ser Val Ser Gln Met Asp Asn Asn Cys Tyr Leu                  10 15 20 ttg gcc gca aat ggc aac ggt tta ctc att gat gct gca gat gac gca 211 Leu Ala Ala Asn Gly Asn Gly Leu Leu Ile Asp Ala Ala Asp Asp Ala              25 30 35 gct gca cta ctt aaa tta gcc gaa gat gcc ggt gtg acc atc acc aaa 259 Ala Ala Leu Leu Lys Leu Ala Glu Asp Ala Gly Val Thr Ile Thr Lys          40 45 50 gtg ttg acc acc cac cgc cac gca gac cac gtc cgt gca ttg ccg gag 307 Val Leu Thr Thr His Arg His Ala Asp His Val Arg Ala Leu Pro Glu      55 60 65 gtt ctc cag aag acc gga gca act cac tac gcg cct ttc ctt gag gtg 355 Val Leu Gln Lys Thr Gly Ala Thr His Tyr Ala Pro Phe Leu Glu Val  70 75 80 85 cca gct ttg ccc tcc gct gtt gat gtg gaa ctg cat cat ggt gat tca 403 Pro Ala Leu Pro Ser Ala Val Asp Val Glu Leu His His Gly Asp Ser                  90 95 100 att gaa ttt gag ggt cat gta ttc cct atc agc att ctg cgc ggc cac 451 Ile Glu Phe Glu Gly His Val Phe Pro Ile Ser Ile Leu Arg Gly His             105 110 115 acc cca ggc ggt gca gta ctc acc gct gag atc gac ggt aaa act cac 499 Thr Pro Gly Gly Ala Val Leu Thr Ala Glu Ile Asp Gly Lys Thr His         120 125 130 ctt ttc gtg ggt gac agc ctc ttc ccc ggc ggt ttg ggc aaa acc agc 547 Leu Phe Val Gly Asp Ser Leu Phe Pro Gly Gly Leu Gly Lys Thr Ser     135 140 145 agc gaa ggc gac ttc gtc cga ctg ttc aac gat gtc aaa gag cgc atc 595 Ser Glu Gly Asp Phe Val Arg Leu Phe Asn Asp Val Lys Glu Arg Ile 150 155 160 165 ttt gac acc tac gac gat gac agc atc gtg tgg cca ggt cac ggc aag 643 Phe Asp Thr Tyr Asp Asp Asp Ser Ile Val Trp Pro Gly His Gly Lys                 170 175 180 gaa acc acc ctt gga gcc gag cgt cca cag ctg gaa atc tgg tgg gag 691 Glu Thr Thr Leu Gly Ala Glu Arg Pro Gln Leu Glu Ile Trp Trp Glu             185 190 195 cgt cgc tgg taagcgcttt tctcaaccag gca 723 Arg Arg Trp         200 <210> 138 <211> 200 <212> PRT <213> Corynebacterium glutamicum <400> 138 Met Thr Asn Glu Leu Thr Leu His His Ile Ser Val Ser Gln Met Asp   1 5 10 15 Asn Asn Cys Tyr Leu Leu Ala Ala Asn Gly Asn Gly Leu Leu Ile Asp              20 25 30 Ala Ala Asp Asp Ala Ala Ala Leu Leu Lys Leu Ala Glu Asp Ala Gly          35 40 45 Val Thr Ile Thr Lys Val Leu Thr Thr His Arg His Ala Asp His Val      50 55 60 Arg Ala Leu Pro Glu Val Leu Gln Lys Thr Gly Ala Thr His Tyr Ala  65 70 75 80 Pro Phe Leu Glu Val Pro Ala Leu Pro Ser Ala Val Asp Val Glu Leu                  85 90 95 His His Gly Asp Ser Ile Glu Phe Glu Gly His Val Phe Pro Ile Ser             100 105 110 Ile Leu Arg Gly His Thr Pro Gly Gly Ala Val Leu Thr Ala Glu Ile         115 120 125 Asp Gly Lys Thr His Leu Phe Val Gly Asp Ser Leu Phe Pro Gly Gly     130 135 140 Leu Gly Lys Thr Ser Ser Glu Gly Asp Phe Val Arg Leu Phe Asn Asp 145 150 155 160 Val Lys Glu Arg Ile Phe Asp Thr Tyr Asp Asp Asp Ser Ile Val Trp                 165 170 175 Pro Gly His Gly Lys Glu Thr Thr Leu Gly Ala Glu Arg Pro Gln Leu             180 185 190 Glu Ile Trp Trp Glu Arg Arg Trp         195 200 <139> <211> 404 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (381) <223> FRXA02424 <400> 139 acc gga gca act cac tac gcg cct ttc ctt gag gtg cca gct ttg ccc 48 Thr Gly Ala Thr His Tyr Ala Pro Phe Leu Glu Val Pro Ala Leu Pro   1 5 10 15 tcc gct gtt gat gtg gaa ctg cat cat ggt gat tca att gaa ttt gag 96 Ser Ala Val Asp Val Glu Leu His His Gly Asp Ser Ile Glu Phe Glu              20 25 30 ggt cat gta ttc cct atc agc att ctg cgc ggc cac acc cca ggc ggt 144 Gly His Val Phe Pro Ile Ser Ile Leu Arg Gly His Thr Pro Gly Gly          35 40 45 gca gta ctc acc gct gag atc gac ggt aaa act cac ctt ttc gtg ggt 192 Ala Val Leu Thr Ala Glu Ile Asp Gly Lys Thr His Leu Phe Val Gly      50 55 60 gac agc ctc ttc ccc ggc ggt ttg ggc aaa acc agc agc gaa ggc gac 240 Asp Ser Leu Phe Pro Gly Gly Leu Gly Lys Thr Ser Ser Glu Gly Asp  65 70 75 80 ttc gtc cga ctg ttc aac gat gtc aaa gag cgc atc ttt gac acc tac 288 Phe Val Arg Leu Phe Asn Asp Val Lys Glu Arg Ile Phe Asp Thr Tyr                  85 90 95 gac gat gac agc atc gtg tgg cca ggt cac ggc aag gaa acc acc ctt 336 Asp Asp Asp Ser Ile Val Trp Pro Gly His Gly Lys Glu Thr Thr Leu             100 105 110 gga gcc gag cgt cca cag ctg gaa atc tgg tgg gag cgt cgc tgg 381 Gly Ala Glu Arg Pro Gln Leu Glu Ile Trp Trp Glu Arg Arg Trp         115 120 125 taagcgcttt tctcaaccag gca 404 <210> 140 <211> 127 <212> PRT <213> Corynebacterium glutamicum <400> 140 Thr Gly Ala Thr His Tyr Ala Pro Phe Leu Glu Val Pro Ala Leu Pro   1 5 10 15 Ser Ala Val Asp Val Glu Leu His His Gly Asp Ser Ile Glu Phe Glu              20 25 30 Gly His Val Phe Pro Ile Ser Ile Leu Arg Gly His Thr Pro Gly Gly          35 40 45 Ala Val Leu Thr Ala Glu Ile Asp Gly Lys Thr His Leu Phe Val Gly      50 55 60 Asp Ser Leu Phe Pro Gly Gly Leu Gly Lys Thr Ser Ser Glu Gly Asp  65 70 75 80 Phe Val Arg Leu Phe Asn Asp Val Lys Glu Arg Ile Phe Asp Thr Tyr                  85 90 95 Asp Asp Asp Ser Ile Val Trp Pro Gly His Gly Lys Glu Thr Thr Leu             100 105 110 Gly Ala Glu Arg Pro Gln Leu Glu Ile Trp Trp Glu Arg Arg Trp         115 120 125 <210> 141 <211> 882 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (859) <223> RXN00419 <400> 141 gctggttgaa gactcgaaat gagatcgacc caaccggagt ctttgcatct gacatgtccc 60 gccgacttga gctttcttaa gaaagggctt gaactaaaca atg ctt aac gca gtg 115                                             Met leu asn ala val                                               1 5 ggc aaa gcc caa aac att ctc ctt ctt ggt gga acc tct gag atc ggt 163 Gly Lys Ala Gln Asn Ile Leu Leu Leu Gly Gly Thr Ser Glu Ile Gly                  10 15 20 att tcc att gtc tcc cgc ttc ctc aag cag ggt cca tcc cat gtg acc 211 Ile Ser Ile Val Ser Arg Phe Leu Lys Gln Gly Pro Ser His Val Thr              25 30 35 ttg gca gcg cgt aaa gat tcc cca cgc gtg gac gca gca gtc gca gag 259 Leu Ala Ala Arg Lys Asp Ser Pro Arg Val Asp Ala Ala Val Ala Glu          40 45 50 atc aaa gca gct ggc gct gct tcc gtt gct gtt gtt gat ttc gat gcg 307 Ile Lys Ala Ala Gly Ala Ala Ser Val Ala Val Val Asp Phe Asp Ala      55 60 65 ctc gac acc gaa tcc cac cct gca gcc atc gac gca gcc ttt gaa aac 355 Leu Asp Thr Glu Ser His Pro Ala Ala Ile Asp Ala Ala Phe Glu Asn  70 75 80 85 ggc gac gtt gac gta gca atc gtg gct ttc ggc atc ctc ggc gac aac 403 Gly Asp Val Asp Val Ala Ile Val Ala Phe Gly Ile Leu Gly Asp Asn                  90 95 100 gaa gca cag tgg cgc gac caa gca cta gca gtg gaa gca acc acc gtg 451 Glu Ala Gln Trp Arg Asp Gln Ala Leu Ala Val Glu Ala Thr Thr Val             105 110 115 aac tac acc gcc ggc gtt tcc gta ggt gta ctg ctg ggc cag aaa ttt 499 Asn Tyr Thr Ala Gly Val Ser Val Gly Val Leu Leu Gly Gln Lys Phe         120 125 130 gag cag cag ggc cac ggc acc atc gtg gca ttg tcc tct gtg gca ggc 547 Glu Gln Gln Gly His Gly Thr Ile Val Ala Leu Ser Ser Val Ala Gly     135 140 145 cag cga gtc cgc cgc tcc aac ttt gtc tac ggc tcc gcc aag gca ggt 595 Gln Arg Val Arg Arg Ser Asn Phe Val Tyr Gly Ser Ala Lys Ala Gly 150 155 160 165 ttc gac ggt ttc tac acc cag ctc ggc gaa gcc ctg cgt gga tcc ggt 643 Phe Asp Gly Phe Tyr Thr Gln Leu Gly Glu Ala Leu Arg Gly Ser Gly                 170 175 180 gcc aac gta ttg gtg gtt cgc cca ggc cag gta cgc acc aag atg tcc 691 Ala Asn Val Leu Val Val Arg Pro Gly Gln Val Arg Thr Lys Met Ser             185 190 195 gca gat ggt ggc gaa gcc cca ctg acc gtc aac cgc gaa gac gtg gca 739 Ala Asp Gly Gly Glu Ala Pro Leu Thr Val Asn Arg Glu Asp Val Ala         200 205 210 gat gct gtt tat gat gca gtg gtg aac aag aag gac atc atc ttt gtc 787 Asp Ala Val Tyr Asp Ala Val Val Asn Lys Lys Asp Ile Ile Phe Val     215 220 225 cac cca ctg ttc cag tac gtc tct ttt gcg ttc caa ttc att ccg cga 835 His Pro Leu Phe Gln Tyr Val Ser Phe Ala Phe Gln Phe Ile Pro Arg 230 235 240 245 gca atc ttc cgc aag ctg ccg ttc taacggaagt tacggaagtt acg 882 Ala Ile Phe Arg Lys Leu Pro Phe                 250 <210> 142 <211> 253 <212> PRT <213> Corynebacterium glutamicum <400> 142 Met Leu Asn Ala Val Gly Lys Ala Gln Asn Ile Leu Leu Leu Gly Gly   1 5 10 15 Thr Ser Glu Ile Gly Ile Ser Ile Val Ser Arg Phe Leu Lys Gln Gly              20 25 30 Pro Ser His Val Thr Leu Ala Ala Arg Lys Asp Ser Pro Arg Val Asp          35 40 45 Ala Ala Val Ala Glu Ile Lys Ala Ala Gly Ala Ala Ser Val Ala Val      50 55 60 Val Asp Phe Asp Ala Leu Asp Thr Glu Ser His Pro Ala Ala Ile Asp  65 70 75 80 Ala Ala Phe Glu Asn Gly Asp Val Asp Val Ala Ile Val Ala Phe Gly                  85 90 95 Ile Leu Gly Asp Asn Glu Ala Gln Trp Arg Asp Gln Ala Leu Ala Val             100 105 110 Glu Ala Thr Thr Val Asn Tyr Thr Ala Gly Val Ser Val Gly Val Leu         115 120 125 Leu Gly Gln Lys Phe Glu Gln Gln Gly His Gly Thr Ile Val Ala Leu     130 135 140 Ser Ser Val Ala Gly Gln Arg Val Arg Arg Ser Asn Phe Val Tyr Gly 145 150 155 160 Ser Ala Lys Ala Gly Phe Asp Gly Phe Tyr Thr Gln Leu Gly Glu Ala                 165 170 175 Leu Arg Gly Ser Gly Ala Asn Val Leu Val Val Arg Pro Gly Gln Val             180 185 190 Arg Thr Lys Met Ser Ala Asp Gly Gly Glu Ala Pro Leu Thr Val Asn         195 200 205 Arg Glu Asp Val Ala Asp Ala Val Tyr Asp Ala Val Val Asn Lys Lys     210 215 220 Asp Ile Ile Phe Val His Pro Leu Phe Gln Tyr Val Ser Phe Ala Phe 225 230 235 240 Gln Phe Ile Pro Arg Ala Ile Phe Arg Lys Leu Pro Phe                 245 250 <210> 143 <211> 485 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (462) <223> FRXA00419 <400> 143 gac aac gaa gca cag tgg cgc gac caa gca cta gca gtg gaa gca acc 48 Asp Asn Glu Ala Gln Trp Arg Asp Gln Ala Leu Ala Val Glu Ala Thr   1 5 10 15 acc gtg aac tac acc gcc ggc gtt tcc gta ggt gta ctg ctg ggc cag 96 Thr Val Asn Tyr Thr Ala Gly Val Ser Val Gly Val Leu Leu Gly Gln              20 25 30 aaa ttt gag cag cag ggc cac ggc acc atc gtg gca ttg tcc tct gtg 144 Lys Phe Glu Gln Gln Gly His Gly Thr Ile Val Ala Leu Ser Ser Val          35 40 45 gca ggc cag cga gtc cgc cgc tcc aac ttt gtc tac ggc tcc gcc aag 192 Ala Gly Gln Arg Val Arg Arg Ser Asn Phe Val Tyr Gly Ser Ala Lys      50 55 60 gca ggt ttc gac ggt ttc tac acc cag ctc ggc gaa gcc ctg cgt gga 240 Ala Gly Phe Asp Gly Phe Tyr Thr Gln Leu Gly Glu Ala Leu Arg Gly  65 70 75 80 tcc ggt gcc aac gta ttg gtg gtt cgc cca ggc cag gta cgc acc aag 288 Ser Gly Ala Asn Val Leu Val Val Arg Pro Gly Gln Val Arg Thr Lys                  85 90 95 atg tcc gca gat ggt ggc gaa gcc cca ctg acc gtc aac cgc gaa gac 336 Met Ser Ala Asp Gly Gly Glu Ala Pro Leu Thr Val Asn Arg Glu Asp             100 105 110 gtg gca gat gct gtt tat gat gca gtg gtg aac aag aag gac atc atc 384 Val Ala Asp Ala Val Tyr Asp Ala Val Val Asn Lys Lys Asp Ile Ile         115 120 125 ttt gtc cac cca ctg ttc cag tac gtc tct ttt gcg ttc caa ttc att 432 Phe Val His Pro Leu Phe Gln Tyr Val Ser Phe Ala Phe Gln Phe Ile     130 135 140 ccg cga gca atc ttc cgc aag ctg ccg ttc taacggaagt tacggaagtt 482 Pro Arg Ala Ile Phe Arg Lys Leu Pro Phe 145 150 acg 485 <210> 144 <211> 154 <212> PRT <213> Corynebacterium glutamicum <400> 144 Asp Asn Glu Ala Gln Trp Arg Asp Gln Ala Leu Ala Val Glu Ala Thr   1 5 10 15 Thr Val Asn Tyr Thr Ala Gly Val Ser Val Gly Val Leu Leu Gly Gln              20 25 30 Lys Phe Glu Gln Gln Gly His Gly Thr Ile Val Ala Leu Ser Ser Val          35 40 45 Ala Gly Gln Arg Val Arg Arg Ser Asn Phe Val Tyr Gly Ser Ala Lys      50 55 60 Ala Gly Phe Asp Gly Phe Tyr Thr Gln Leu Gly Glu Ala Leu Arg Gly  65 70 75 80 Ser Gly Ala Asn Val Leu Val Val Arg Pro Gly Gln Val Arg Thr Lys                  85 90 95 Met Ser Ala Asp Gly Gly Glu Ala Pro Leu Thr Val Asn Arg Glu Asp             100 105 110 Val Ala Asp Ala Val Tyr Asp Ala Val Val Asn Lys Lys Asp Ile Ile         115 120 125 Phe Val His Pro Leu Phe Gln Tyr Val Ser Phe Ala Phe Gln Phe Ile     130 135 140 Pro Arg Ala Ile Phe Arg Lys Leu Pro Phe 145 150 <210> 145 <211> 259 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (259) <223> FRXA00421 <400> 145 gctggttgaa gactcgaaat gagatcgacc caaccggagt ctttgcatct gacatgtccc 60 gccgacttga gctttcttaa gaaagggctt gaactaaaca atg ctt aac gca gtg 115                                             Met leu asn ala val                                               1 5 ggc aaa gcc caa aac att ctc ctt ctt ggt gga acc tct gag atc ggt 163 Gly Lys Ala Gln Asn Ile Leu Leu Leu Gly Gly Thr Ser Glu Ile Gly                  10 15 20 att tcc att gtc tcc cgc ttc ctc aag cag ggt cca tcc cat gtg acc 211 Ile Ser Ile Val Ser Arg Phe Leu Lys Gln Gly Pro Ser His Val Thr              25 30 35 ttg gca gcg cgt aaa gat tcc cca cgc gtg gac gca gca gtc gca gag 259 Leu Ala Ala Arg Lys Asp Ser Pro Arg Val Asp Ala Ala Val Ala Glu          40 45 50 <210> 146 <211> 53 <212> PRT <213> Corynebacterium glutamicum <400> 146 Met Leu Asn Ala Val Gly Lys Ala Gln Asn Ile Leu Leu Leu Gly Gly   1 5 10 15 Thr Ser Glu Ile Gly Ile Ser Ile Val Ser Arg Phe Leu Lys Gln Gly              20 25 30 Pro Ser His Val Thr Leu Ala Ala Arg Lys Asp Ser Pro Arg Val Asp          35 40 45 Ala Ala Val Ala Glu      50 <210> 147 <211> 861 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (838) <223> RXN02923 <400> 147 gcatctacat tgaaggaatc cacggagcgc gcatcgaaga catcgttgtg gtgaatgaag 60 acggttgtga aaccctcaac aaccagccca aggaactgcg ttg agc att ctt ctc 115                                             Leu Ser Ile Leu Leu                                               1 5 cta ggc gga acc tct gac att gcc ggt gag att gcc acg ttg acg tgt 163 Leu Gly Gly Thr Ser Asp Ile Ala Gly Glu Ile Ala Thr Leu Thr Cys                  10 15 20 cac ggc gaa gac gtt gtt ttg gct gct cgt cga cca gag gct gca cag 211 His Gly Glu Asp Val Val Leu Ala Ala Arg Arg Pro Glu Ala Ala Gln              25 30 35 ggc tta gcg gaa gat ctt cga cag cgc ggt gcc aca tct gtt cat gtt 259 Gly Leu Ala Glu Asp Leu Arg Gln Arg Gly Ala Thr Ser Val His Val          40 45 50 ttg agc ttt gac gcc caa gta cta gac acg cac cga gaa ctt gtg aag 307 Leu Ser Phe Asp Ala Gln Val Leu Asp Thr His Arg Glu Leu Val Lys      55 60 65 aaa aca caa gag cta gct ggc gag att tcc ctt gcc gtg gtt gct ttt 355 Lys Thr Gln Glu Leu Ala Gly Glu Ile Ser Leu Ala Val Val Ala Phe  70 75 80 85 ggc atc ttg gga gac caa gaa cgc gca gaa acc gat gag acc cat gcg 403 Gly Ile Leu Gly Asp Gln Glu Arg Ala Glu Thr Asp Glu Thr His Ala                  90 95 100 gta gag atc gcc acc gtg gat tac acc gct cag gtc tcc atg ctc act 451 Val Glu Ile Ala Thr Val Asp Tyr Thr Ala Gln Val Ser Met Leu Thr             105 110 115 gtg ctt gct gat gag ctc cgc gca caa act act cca gca gcg atc gtg 499 Val Leu Ala Asp Glu Leu Arg Ala Gln Thr Thr Pro Ala Ala Ile Val         120 125 130 gcg ttt tcc tcg att gct ggg tgg cgg gcg cgc cgg cct aac tat gtc 547 Ala Phe Ser Ser Ile Ala Gly Trp Arg Ala Arg Arg Pro Asn Tyr Val     135 140 145 tat gga tcc acc aag gct ggt ctc gat gca ttt tgc caa ggg ctt gca 595 Tyr Gly Ser Thr Lys Ala Gly Leu Asp Ala Phe Cys Gln Gly Leu Ala 150 155 160 165 gat agc ctg cat ggg aca cac gtg cga ttg att att gcg cgt cct ggc 643 Asp Ser Leu His Gly Thr His Val Arg Leu Ile Ala Arg Pro Gly                 170 175 180 ttt gtt att ggt tct atg acc acg ggg atg aag cct gct ccg atg tcg 691 Phe Val Ile Gly Ser Met Thr Thr Gly Met Lys Pro Ala Pro Met Ser             185 190 195 gtg tat cca cga gat gtt gcc gca gct gtt gtt agt gct tat acc tct 739 Val Tyr Pro Arg Asp Val Ala Ala Ala Val Val Ser Ala Tyr Thr Ser         200 205 210 aag aag agg agc acg acc ttg tgg att ccg gga cgt ctg cgg gtt ctc 787 Lys Lys Arg Ser Thr Thr Leu Trp Ile Pro Gly Arg Leu Arg Val Leu     215 220 225 gcc tgg att atg cgg atg gtt cct cgt ccg gtg tgg cgg aag atg cca 835 Ala Trp Ile Met Arg Met Val Pro Arg Pro Val Trp Arg Lys Met Pro 230 235 240 245 cgc tagatacccg ttcagccctc aca 861 Arg <210> 148 <211> 246 <212> PRT <213> Corynebacterium glutamicum <400> 148 Leu Ser Ile Leu Leu Leu Gly Gly Thr Ser Asp Ile Ala Gly Glu Ile   1 5 10 15 Ala Thr Leu Thr Cys His Gly Glu Asp Val Val Leu Ala Ala Arg Arg              20 25 30 Pro Glu Ala Ala Gln Gly Leu Ala Glu Asp Leu Arg Gln Arg Gly Ala          35 40 45 Thr Ser Val His Val Leu Ser Phe Asp Ala Gln Val Leu Asp Thr His      50 55 60 Arg Glu Leu Val Lys Lys Thr Gln Glu Leu Ala Gly Glu Ile Ser Leu  65 70 75 80 Ala Val Val Ala Phe Gly Ile Leu Gly Asp Gln Glu Arg Ala Glu Thr                  85 90 95 Asp Glu Thr His Ala Val Glu Ile Ala Thr Val Asp Tyr Thr Ala Gln             100 105 110 Val Ser Met Leu Thr Val Leu Ala Asp Glu Leu Arg Ala Gln Thr Thr         115 120 125 Pro Ala Ala Ile Val Ala Phe Ser Ser Ile Ala Gly Trp Arg Ala Arg     130 135 140 Arg Pro Asn Tyr Val Tyr Gly Ser Thr Lys Ala Gly Leu Asp Ala Phe 145 150 155 160 Cys Gln Gly Leu Ala Asp Ser Leu His Gly Thr His Val Arg Leu Ile                 165 170 175 Ile Ala Arg Pro Gly Phe Val Ile Gly Ser Met Thr Thr Gly Met Lys             180 185 190 Pro Ala Pro Met Ser Val Tyr Pro Arg Asp Val Ala Ala Ala Val Val         195 200 205 Ser Ala Tyr Thr Ser Lys Lys Arg Ser Thr Thr Leu Trp Ile Pro Gly     210 215 220 Arg Leu Arg Val Leu Ala Trp Ile Met Arg Met Val Pro Arg Pro Val 225 230 235 240 Trp Arg Lys Met Pro Arg                 245 <210> 149 <211> 1203 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (1180) <223> RXN02922 <400> 149 cccaccgcgg cgcaagctac cgcctaggcg ctcggaactc caccgccact attgatctca 60 gttccatatc cgcccaacta gtttcccagg gagcccactc atg atc tca ccg caa 115                                             Met Ile Ser Pro Gln                                               1 5 aca atc atc gac aat ctt gct cca gtc ctc gcg gag atc gca gca acg 163 Thr Ile Ile Asp Asn Leu Ala Pro Val Leu Ala Glu Ile Ala Ala Thr                  10 15 20 gct gcg cag cgc gaa cag gat cga gaa ttc agc cgt gat ttg gca aag 211 Ala Ala Gln Arg Glu Gln Asp Arg Glu Phe Ser Arg Asp Leu Ala Lys              25 30 35 cag ctt agt gcc ggt ggg ttc act aaa ctc cgc att cca gtt gaa ttt 259 Gln Leu Ser Ala Gly Gly Phe Thr Lys Leu Arg Ile Pro Val Glu Phe          40 45 50 ggc ggt ttg ggt ttt agc ctt cca gaa gca ttt gag gtg ctg gtg gca 307 Gly Gly Leu Gly Phe Ser Leu Pro Glu Ala Phe Glu Val Leu Val Ala      55 60 65 gcg gcc gct gca gat tca aat atc gcg cag gga ttg cgg cct cac ttc 355 Ala Ala Ala Ala Asp Ser Asn Ile Ala Gln Gly Leu Arg Pro His Phe  70 75 80 85 ttg gca gtg gag agc tta ttg atc gct cct tat tca gag cac cgc acc 403 Leu Ala Val Glu Ser Leu Leu Ile Ala Pro Tyr Ser Glu His Arg Thr                  90 95 100 aag tgg ctg cga aaa atc gct gag aaa ggc gtg gtc att ggc aat gcg 451 Lys Trp Leu Arg Lys Ile Ala Glu Lys Gly Val Val Ile Gly Asn Ala             105 110 115 ttg act gaa gtg gga aac aag cca ggt gag ctg aaa acc aag atc cga 499 Leu Thr Glu Val Gly Asn Lys Pro Gly Glu Leu Lys Thr Lys Ile Arg         120 125 130 aag gaa ggc gag tct tac gtt ctc agc gac acc aag ttc tat tcc acg 547 Lys Glu Gly Glu Ser Tyr Val Leu Ser Asp Thr Lys Phe Tyr Ser Thr     135 140 145 ggc agt ctt tac gcc gac tgg att caa gta cat gcg aaa gat gag gaa 595 Gly Ser Leu Tyr Ala Asp Trp Ile Gln Val His Ala Lys Asp Glu Glu 150 155 160 165 gat caa gat gtt ttc gcc ttt gtt gat cgc gac gca tca ggc gtt gtt 643 Asp Gln Asp Val Phe Ala Phe Val Asp Arg Asp Ala Ser Gly Val Val                 170 175 180 ttg gtg gat tac tgg gac gaa ttt ggg caa caa cta ttt gcc tcc gga 691 Leu Val Asp Tyr Trp Asp Glu Phe Gly Gln Gln Leu Phe Ala Ser Gly             185 190 195 acc agc ttc ttt gaa aaa gtc gtg gta gat cca ctg gac att gtc acc 739 Thr Ser Phe Phe Glu Lys Val Val Val Asp Pro Leu Asp Ile Val Thr         200 205 210 cgt gat tac acc gca ccc agc gct ttc cag gcg ctg gcg cag tca cat 787 Arg Asp Tyr Thr Ala Pro Ser Ala Phe Gln Ala Leu Ala Gln Ser His     215 220 225 cat ttg tct acg ttg act ggt att tcg cag gca atc acc cgt gac att 835 His Leu Ser Thr Leu Thr Gly Ile Ser Gln Ala Ile Thr Arg Asp Ile 230 235 240 245 gtt acc tat gta caa aac cgc acc cgt att ttc agc cac gga agt ggt 883 Val Thr Tyr Val Gln Asn Arg Thr Arg Ile Phe Ser His Gly Ser Gly                 250 255 260 gac ctt cca cgc ttt gat ccg cag gtg caa cag gtg gtg ggt gag gtg 931 Asp Leu Pro Arg Phe Asp Pro Gln Val Gln Gln Val Val Gly Glu Val             265 270 275 aaa gcc aag tcg tat gca gtc gag aaa atc ttt cag ggt ttc gca caa 979 Lys Ala Lys Ser Tyr Ala Val Glu Lys Ile Phe Gln Gly Phe Ala Gln         280 285 290 gaa ctg gat ctt gtc gtc gat aag gca aaa gcc ggc act gct acg gag 1027 Glu Leu Asp Leu Val Val Asp Lys Ala Lys Ala Gly Thr Ala Thr Glu     295 300 305 gtc gat ctg gcc gct gtc gac ctg agc gcc tac caa gcc cag tta gcg 1075 Val Asp Leu Ala Ala Val Asp Leu Ser Ala Tyr Gln Ala Gln Leu Ala 310 315 320 325 gtg gca cct ttg gtg ctg agc cag gcc acc cag gcc ttt gag gtt ggc 1123 Val Ala Pro Leu Val Leu Ser Gln Ala Thr Gln Ala Phe Glu Val Gly                 330 335 340 gca gat gcc tta aac ggc ggc cac gtg gct gcc caa tac acg atc gga 1171 Ala Asp Ala Leu Asn Gly Gly His Val Ala Ala Gln Tyr Thr Ile Gly             345 350 355 tcc ttg tca tgagccaaga aattttgagc cat 1203 Ser Leu Ser         360 <210> 150 <211> 360 <212> PRT <213> Corynebacterium glutamicum <400> 150 Met Ile Ser Pro Gln Thr Ile Ile Asp Asn Leu Ala Pro Val Leu Ala   1 5 10 15 Glu Ile Ala Ala Thr Ala Ala Gln Arg Glu Gln Asp Arg Glu Phe Ser              20 25 30 Arg Asp Leu Ala Lys Gln Leu Ser Ala Gly Gly Phe Thr Lys Leu Arg          35 40 45 Ile Pro Val Glu Phe Gly Gly Leu Gly Phe Ser Leu Pro Glu Ala Phe      50 55 60 Glu Val Leu Val Ala Ala Ala Ala Ala Asp Ser Asn Ile Ala Gln Gly  65 70 75 80 Leu Arg Pro His Phe Leu Ala Val Glu Ser Leu Leu Ile Ala Pro Tyr                  85 90 95 Ser Glu His Arg Thr Lys Trp Leu Arg Lys Ile Ala Glu Lys Gly Val             100 105 110 Val Ile Gly Asn Ala Leu Thr Glu Val Gly Asn Lys Pro Gly Glu Leu         115 120 125 Lys Thr Lys Ile Arg Lys Glu Gly Glu Ser Tyr Val Leu Ser Asp Thr     130 135 140 Lys Phe Tyr Ser Thr Gly Ser Leu Tyr Ala Asp Trp Ile Gln Val His 145 150 155 160 Ala Lys Asp Glu Glu Asp Gln Asp Val Phe Ala Phe Val Asp Arg Asp                 165 170 175 Ala Ser Gly Val Val Leu Val Asp Tyr Trp Asp Glu Phe Gly Gln Gln             180 185 190 Leu Phe Ala Ser Gly Thr Ser Phe Phe Glu Lys Val Val Val Asp Pro         195 200 205 Leu Asp Ile Val Thr Arg Asp Tyr Thr Ala Pro Ser Ala Phe Gln Ala     210 215 220 Leu Ala Gln Ser His His Leu Ser Thr Leu Thr Gly Ile Ser Gln Ala 225 230 235 240 Ile Thr Arg Asp Ile Val Thr Tyr Val Gln Asn Arg Thr Arg Ile Phe                 245 250 255 Ser His Gly Ser Gly Asp Leu Pro Arg Phe Asp Pro Gln Val Gln Gln             260 265 270 Val Val Gly Glu Val Lys Ala Lys Ser Tyr Ala Val Glu Lys Ile Phe         275 280 285 Gln Gly Phe Ala Gln Glu Leu Asp Leu Val Val Asp Lys Ala Lys Ala     290 295 300 Gly Thr Ala Thr Glu Val Asp Leu Ala Ala Val Asp Leu Ser Ala Tyr 305 310 315 320 Gln Ala Gln Leu Ala Val Ala Pro Leu Val Leu Ser Gln Ala Thr Gln                 325 330 335 Ala Phe Glu Val Gly Ala Asp Ala Leu Asn Gly Gly His Val Ala Ala             340 345 350 Gln Tyr Thr Ile Gly Ser Leu Ser         355 360 <210> 151 <211> 516 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (493) <223> RXN03065 <400> 151 gacggcgcca actctgcatt cttcgcctca gcgtgcgtgg cagtgtttgc actgatcgtg 60 ggcttctttg taaagaggcc agcccgctaa gctaggtcgc atg atc agc att gga 115                                             Met Ile Ser Ile Gly                                               1 5 acc gac ctc gtt cac att tcg gcg ttc gca gag cag ctt gca cag ccg 163 Thr Asp Leu Val His Ile Ser Ala Phe Ala Glu Gln Leu Ala Gln Pro                  10 15 20 gga agt tcc ttc atg gag gtg ttt tcc gca ggg gag cgt cgt aaa gca 211 Gly Ser Ser Phe Met Glu Val Phe Ser Ala Gly Glu Arg Arg Lys Ala              25 30 35 aat gaa cgc cag gca agc cgc tac gcc gag cat ttg gcg ggg cgg tgg 259 Asn Glu Arg Gln Ala Ser Arg Tyr Ala Glu His Leu Ala Gly Arg Trp          40 45 50 gcg gca aaa gaa tcc ttt att aag gcc tgg tca cag gcc att tat ggc 307 Ala Ala Lys Glu Ser Phe Ile Lys Ala Trp Ser Gln Ala Ile Tyr Gly      55 60 65 cag cca ccc gtg atc gcc gaa gaa gcc gtg gtg tgg cgg gac atc gaa 355 Gln Pro Pro Val Ile Ala Glu Glu Ala Val Val Trp Arg Asp Ile Glu  70 75 80 85 gtt cgc gca gac gcg tgg ggg cgc gtc gcg atc gaa ttg gcg ccc gaa 403 Val Arg Ala Asp Ala Trp Gly Arg Val Ala Ile Glu Leu Ala Pro Glu                  90 95 100 ttg gcc gca gtg gtc cgg gaa tcc atc ggg gag ttt tcc agc agc ttg 451 Leu Ala Ala Val Val Arg Glu Ser Ile Gly Glu Phe Ser Ser Ser Leu             105 110 115 agc atc agc cac gac ggc gac tac gcg gtg gaa cgt gcg tgt 493 Ser Ile Ser His Asp Gly Asp Tyr Ala Val Glu Arg Ala Cys         120 125 130 tgactatcca gtagccacgg aga 516 <210> 152 <211> 131 <212> PRT <213> Corynebacterium glutamicum <400> 152 Met Ile Ser Ile Gly Thr Asp Leu Val His Ile Ser Ala Phe Ala Glu   1 5 10 15 Gln Leu Ala Gln Pro Gly Ser Ser Phe Met Glu Val Phe Ser Ala Gly              20 25 30 Glu Arg Arg Lys Ala Asn Glu Arg Gln Ala Ser Arg Tyr Ala Glu His          35 40 45 Leu Ala Gly Arg Trp Ala Ala Lys Glu Ser Phe Ile Lys Ala Trp Ser      50 55 60 Gln Ala Ile Tyr Gly Gln Pro Pro Val Ile Ala Glu Glu Ala Val Val  65 70 75 80 Trp Arg Asp Ile Glu Val Arg Ala Asp Ala Trp Gly Arg Val Ala Ile                  85 90 95 Glu Leu Ala Pro Glu Leu Ala Ala Val Val Arg Glu Ser Ile Gly Glu             100 105 110 Phe Ser Ser Ser Leu Ser Ile Ser His Asp Gly Asp Tyr Ala Val Glu         115 120 125 Arg Ala Cys     130 <210> 153 <211> 543 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (520) <223> RXN03132 <400> 153 taacttattt atacataaaa acacaataaa aaccgcacac gcggcgaaac ttcaataaat 60 ccctagactg caaaaaatgg ttaggctaac cttatttcca atg aat gtg aat caa 115                                             Met Asn Val Asn Gln                                               1 5 cag ttg gga gcc cgc acc gcc atg aac cac cct gag acc gca acc gtc 163 Gln Leu Gly Ala Arg Thr Ala Met Asn His Pro Glu Thr Ala Thr Val                  10 15 20 ctt cgc tcc atc tct gac atg gtt agc acc gaa acc aat ccg cgc cgt 211 Leu Arg Ser Ile Ser Asp Met Val Ser Thr Glu Thr Asn Pro Arg Arg              25 30 35 aaa agc cgc ctc gag cag ctc att tac gcc acc gcc agc gcc tgg ccc 259 Lys Ser Arg Leu Glu Gln Leu Ile Tyr Ala Thr Ala Ser Ala Trp Pro          40 45 50 cac tac ccc att gcc cac gca gcc cag gcc gcg gtg caa tta gcc agg 307 His Tyr Pro Ile Ala His Ala Ala Gln Ala Ala Val Gln Leu Ala Arg      55 60 65 cca atg cgg gtt ttt gag ctc cag agc ttt gaa ggc gtc aag cac gca 355 Pro Met Arg Val Phe Glu Leu Gln Ser Phe Glu Gly Val Lys His Ala  70 75 80 85 ctc cac cac atc gat ctt cgc ccc gcc ctc gaa tgg gac atc atg gga 403 Leu His His Ile Asp Leu Arg Pro Ala Leu Glu Trp Asp Ile Met Gly                  90 95 100 ttt ccc gaa tcc ccc gac acg ctg ccc att ttg ctc agt gac ctg cgc 451 Phe Pro Glu Ser Pro Asp Thr Leu Pro Ile Leu Leu Ser Asp Leu Arg             105 110 115 gac ccc cct tac gcc acc act gct gtg cca cct caa tcc acg cca cgc 499 Asp Pro Pro Tyr Ala Thr Thr Ala Val Pro Pro Gln Ser Thr Pro Arg         120 125 130 tcc gct cac cga tcc aca cat tgacgcttcc aggcgccacc gcg 543 Ser Ala His Arg Ser Thr His     135 140 <210> 154 <211> 140 <212> PRT <213> Corynebacterium glutamicum <400> 154 Met Asn Val Asn Gln Gln Leu Gly Ala Arg Thr Ala Met Asn His Pro   1 5 10 15 Glu Thr Ala Thr Val Leu Arg Ser Ile Ser Asp Met Val Ser Thr Glu              20 25 30 Thr Asn Pro Arg Arg Lys Ser Arg Leu Glu Gln Leu Ile Tyr Ala Thr          35 40 45 Ala Ser Ala Trp Pro His Tyr Pro Ile Ala His Ala Ala Gln Ala Ala      50 55 60 Val Gln Leu Ala Arg Pro Met Arg Val Phe Glu Leu Gln Ser Phe Glu  65 70 75 80 Gly Val Lys His Ala Leu His His Ile Asp Leu Arg Pro Ala Leu Glu                  85 90 95 Trp Asp Ile Met Gly Phe Pro Glu Ser Pro Asp Thr Leu Pro Ile Leu             100 105 110 Leu Ser Asp Leu Arg Asp Pro Pro Tyr Ala Thr Thr Ala Val Pro Pro         115 120 125 Gln Ser Thr Pro Arg Ser Ala His Arg Ser Thr His     130 135 140 <210> 155 <211> 461 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (438) <223> RXN03157 <400> 155 ggc cac ctc gac atc gtg acc cgc gcc gcc gcg caa ttt agc gaa gtc 48 Gly His Leu Asp Ile Val Thr Arg Ala Ala Ala Gln Phe Ser Glu Val   1 5 10 15 acc atc ttg gtc acc gcc aac ccc aac aaa aac tca gga ctg ttc acc 96 Thr Ile Leu Val Thr Ala Asn Pro Asn Lys Asn Ser Gly Leu Phe Thr              20 25 30 gtc gca gaa cgc atg gat ctc atc cgc gaa tcc acc gca cac ctg gac 144 Val Ala Glu Arg Met Asp Leu Ile Arg Glu Ser Thr Ala His Leu Asp          35 40 45 aac gta aaa gta gac act tgg gcc tca ctg ctc gtg gat tac acc acc 192 Asn Val Lys Val Asp Thr Trp Ala Ser Leu Leu Val Asp Tyr Thr Thr      50 55 60 gaa cat ggc atc ggc gcc cta gtc aaa ggc ctg cga agc tcc ctc gac 240 Glu His Gly Ile Gly Ala Leu Val Lys Gly Leu Arg Ser Ser Leu Asp  65 70 75 80 tac gaa tac gag ctc ccc atg gca cag atg aac agg cga ctc acg ggc 288 Tyr Glu Tyr Glu Leu Pro Met Ala Gln Met Asn Arg Arg Leu Thr Gly                  85 90 95 gta gac acc ttc ttc ctc ctc acc gac gag aaa tac ggc tac gtc agc 336 Val Asp Thr Phe Phe Leu Leu Thr Asp Glu Lys Tyr Gly Tyr Val Ser             100 105 110 tcc aca ctg tgc aaa gaa gtt gcc cgc ttc ggt ggc gat gtc tcc ggc 384 Ser Thr Leu Cys Lys Glu Val Ala Arg Phe Gly Gly Asp Val Ser Gly         115 120 125 ctc cta cct gag gta gtg gca aaa gcc gtg aca gaa aaa tac agc aac 432 Leu Leu Pro Glu Val Val Ala Lys Ala Val Thr Glu Lys Tyr Ser Asn     130 135 140 cag cac tagtttcttt tgcatcaagc gtc 461 Gln his 145 <210> 156 <211> 146 <212> PRT <213> Corynebacterium glutamicum <400> 156 Gly His Leu Asp Ile Val Thr Arg Ala Ala Ala Gln Phe Ser Glu Val   1 5 10 15 Thr Ile Leu Val Thr Ala Asn Pro Asn Lys Asn Ser Gly Leu Phe Thr              20 25 30 Val Ala Glu Arg Met Asp Leu Ile Arg Glu Ser Thr Ala His Leu Asp          35 40 45 Asn Val Lys Val Asp Thr Trp Ala Ser Leu Leu Val Asp Tyr Thr Thr      50 55 60 Glu His Gly Ile Gly Ala Leu Val Lys Gly Leu Arg Ser Ser Leu Asp  65 70 75 80 Tyr Glu Tyr Glu Leu Pro Met Ala Gln Met Asn Arg Arg Leu Thr Gly                  85 90 95 Val Asp Thr Phe Phe Leu Leu Thr Asp Glu Lys Tyr Gly Tyr Val Ser             100 105 110 Ser Thr Leu Cys Lys Glu Val Ala Arg Phe Gly Gly Asp Val Ser Gly         115 120 125 Leu Leu Pro Glu Val Val Ala Lys Ala Val Thr Glu Lys Tyr Ser Asn     130 135 140 Gln his 145 <210> 157 <211> 1206 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (1183) <223> RXN00934 <400> 157 ccaacccctg tggtttggtg atttggatcc ggagcgtctc aagcgctcta gggagcagac 60 aaatgttcac aaaccggtgg cattacagga ggacaattag gtg cga att gga atg 115                                             Val Arg Ile Gly Met                                               1 5 gtc tgc ccg tac tcc ttc gat gag ccg ggc ggt gtt caa gcg cat atc 163 Val Cys Pro Tyr Ser Phe Asp Glu Pro Gly Gly Val Gln Ala His Ile                  10 15 20 ctt gac tta gcg cga acc ttc att gcc caa ggc cat gag gtt cag gtg 211 Leu Asp Leu Ala Arg Thr Phe Ile Ala Gln Gly His Glu Val Gln Val              25 30 35 ctt ggt ccg tgt agt gcg gat acg cag gtg ccc gat ttc gtg gtg cgc 259 Leu Gly Pro Cys Ser Ala Asp Thr Gln Val Pro Asp Phe Val Val Arg          40 45 50 ggt ggt ggc agc atc ccg att ccg tac aat ggc tcg gtt gcc cgc ttg 307 Gly Gly Gly Ser Ile Pro Ile Pro Tyr Asn Gly Ser Val Ala Arg Leu      55 60 65 agc ttt ggg ccg aaa atg ttc aag gcc gtg cgc acg ttc ctc cgc gaa 355 Ser Phe Gly Pro Lys Met Phe Lys Ala Val Arg Thr Phe Leu Arg Glu  70 75 80 85 ggc aac ttc gat gtg ctg cat atc cat gaa ccg aat tca cca agt ttt 403 Gly Asn Phe Asp Val Leu His Ile His Glu Pro Asn Ser Pro Ser Phe                  90 95 100 tcc atg gcg gcg cta cgc ttt gcg gaa ggc ccc atc gtt gct act tac 451 Ser Met Ala Ala Leu Arg Phe Ala Glu Gly Pro Ile Val Ala Thr Tyr             105 110 115 cac gcc tcc agt agc gga tcg aag ctg ctc aag gct ttc tta cca gtg 499 His Ala Ser Ser Ser Gly Ser Lys Leu Leu Lys Ala Phe Leu Pro Val         120 125 130 ctt tcg ccc atg ctg gag aaa gtg cgc gca ggc atc gcc gtg tct gaa 547 Leu Ser Pro Met Leu Glu Lys Val Arg Ala Gly Ile Ala Val Ser Glu     135 140 145 atg gct cgg cgc tgg cag gtg gag caa gtc ggc ggc gat ccc gtg ctg 595 Met Ala Arg Arg Trp Gln Val Glu Gln Val Gly Gly Asp Pro Val Leu 150 155 160 165 atc ccc aac ggg gta gag acc tcc atg ttc aaa gcc gcg cgc caa atc 643 Ile Pro Asn Gly Val Glu Thr Ser Met Phe Lys Ala Ala Arg Gln Ile                 170 175 180 gaa ccg aat gat cct gta gag atc gtc ttt ttg ggt cgc ctc gat gag 691 Glu Pro Asn Asp Pro Val Glu Ile Val Phe Leu Gly Arg Leu Asp Glu             185 190 195 tcc cgc aaa ggc ctc gac atc ctc ctg cgc gct ctg acc agg ctg gat 739 Ser Arg Lys Gly Leu Asp Ile Leu Leu Arg Ala Leu Thr Arg Leu Asp         200 205 210 cgc ccg ttt acc tgc acc gtc att ggc ggc ggc acc ccg cga gaa gtc 787 Arg Pro Phe Thr Cys Thr Val Ile Gly Gly Gly Thr Pro Arg Glu Val     215 220 225 gcc ggc atc aac ttt gtg ggc cgc gtc agc gat gag gaa aag gca gca 835 Ala Gly Ile Asn Phe Val Gly Arg Val Ser Asp Glu Glu Lys Ala Ala 230 235 240 245 atc tta ggt cgc gca gac atc tat gtc gca ccc aac acc ggc ggc gaa 883 Ile Leu Gly Arg Ala Asp Ile Tyr Val Ala Pro Asn Thr Gly Gly Glu                 250 255 260 agc ttc ggc atc gtg cta gtt gaa gcg atg gcc gcg gga tgc gct gtc 931 Ser Phe Gly Ile Val Leu Val Glu Ala Met Ala Ala Gly Cys Ala Val             265 270 275 gtc gcc agc gac cta gaa gcg ttc tcc ctg gtc acc gat tct gaa gcc 979 Val Ala Ser Asp Leu Glu Ala Phe Ser Leu Val Thr Asp Ser Glu Ala         280 285 290 gca cag cca gcg ggc gtg cta ttt aaa acc ggc tca gac gcc gac cta 1027 Ala Gln Pro Ala Gly Val Leu Phe Lys Thr Gly Ser Asp Ala Asp Leu     295 300 305 gcc aaa aaa ctt caa gcg ctt atc gac gac ccc tcc tcc cgt tcc acg 1075 Ala Lys Lys Leu Gln Ala Leu Ile Asp Asp Pro Ser Ser Arg Ser Thr 310 315 320 325 ctt atc gcc gcg ggg cta aag cgc gca aac gcc tac gac tgg tcg aca 1123 Leu Ile Ala Ala Gly Leu Lys Arg Ala Asn Ala Tyr Asp Trp Ser Thr                 330 335 340 gta tcc acc cag gtc atg gca gtc tat gaa acc att gcg atc gac aaa 1171 Val Ser Thr Gln Val Met Ala Val Tyr Glu Thr Ile Ala Ile Asp Lys             345 350 355 gtg agg ctt gga tgacccttgt ttacctcctc atc 1206 Val Arg Leu Gly         360 <210> 158 <211> 361 <212> PRT <213> Corynebacterium glutamicum <400> 158 Val Arg Ile Gly Met Val Cys Pro Tyr Ser Phe Asp Glu Pro Gly Gly   1 5 10 15 Val Gln Ala His Ile Leu Asp Leu Ala Arg Thr Phe Ile Ala Gln Gly              20 25 30 His Glu Val Gln Val Leu Gly Pro Cys Ser Ala Asp Thr Gln Val Pro          35 40 45 Asp Phe Val Val Arg Gly Gly Gly Ser Ile Pro Ile Pro Tyr Asn Gly      50 55 60 Ser Val Ala Arg Leu Ser Phe Gly Pro Lys Met Phe Lys Ala Val Arg  65 70 75 80 Thr Phe Leu Arg Glu Gly Asn Phe Asp Val Leu His Ile His Glu Pro                  85 90 95 Asn Ser Pro Ser Phe Ser Met Ala Ala Leu Arg Phe Ala Glu Gly Pro             100 105 110 Ile Val Ala Thr Tyr His Ala Ser Ser Ser Gly Ser Lys Leu Leu Lys         115 120 125 Ala Phe Leu Pro Val Leu Ser Pro Met Leu Glu Lys Val Arg Ala Gly     130 135 140 Ile Ala Val Ser Glu Met Ala Arg Arg Trp Gln Val Glu Gln Val Gly 145 150 155 160 Gly Asp Pro Val Leu Ile Pro Asn Gly Val Glu Thr Ser Met Phe Lys                 165 170 175 Ala Ala Arg Gln Ile Glu Pro Asn Asp Pro Val Glu Ile Val Phe Leu             180 185 190 Gly Arg Leu Asp Glu Ser Arg Lys Gly Leu Asp Ile Leu Leu Arg Ala         195 200 205 Leu Thr Arg Leu Asp Arg Pro Phe Thr Cys Thr Val Ile Gly Gly Gly     210 215 220 Thr Pro Arg Glu Val Ala Gly Ile Asn Phe Val Gly Arg Val Ser Asp 225 230 235 240 Glu Glu Lys Ala Ala Ile Leu Gly Arg Ala Asp Ile Tyr Val Ala Pro                 245 250 255 Asn Thr Gly Gly Glu Ser Phe Gly Ile Val Leu Val Glu Ala Met Ala             260 265 270 Ala Gly Cys Ala Val Val Ala Ser Asp Leu Glu Ala Phe Ser Leu Val         275 280 285 Thr Asp Ser Glu Ala Ala Gln Pro Ala Gly Val Leu Phe Lys Thr Gly     290 295 300 Ser Asp Ala Asp Leu Ala Lys Lys Leu Gln Ala Leu Ile Asp Asp Pro 305 310 315 320 Ser Ser Arg Ser Thr Leu Ile Ala Ala Gly Leu Lys Arg Ala Asn Ala                 325 330 335 Tyr Asp Trp Ser Thr Val Ser Thr Gln Val Met Ala Val Tyr Glu Thr             340 345 350 Ile Ala Ile Asp Lys Val Arg Leu Gly         355 360 <210> 159 <211> 1320 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1297) <223> RXN00792 <400> 159 cacctttggt gctgagccag gccacccagg cctttgaggt tggcgcagat gccttaaacg 60 gcggccacgt ggctgcccaa tacacgatcg gatccttgtc atg agc caa gaa att 115                                             Met Ser Gln Glu Ile                                               1 5 ttg agc cat ttt gca ccc gca tta gag cgc att cga agc ggc gcc gtc 163 Leu Ser His Phe Ala Pro Ala Leu Glu Arg Ile Arg Ser Gly Ala Val                  10 15 20 gag cgc gaa cag cag cgc gcc ttg cca gtg gaa gag att aaa gag ctg 211 Glu Arg Glu Gln Gln Arg Ala Leu Pro Val Glu Glu Ile Lys Glu Leu              25 30 35 gta gag cta ggt ttt act ggg ctt cga gtg ccc gaa gaa cta ggc ggt 259 Val Glu Leu Gly Phe Thr Gly Leu Arg Val Pro Glu Glu Leu Gly Gly          40 45 50 gcg ggc gct tcc ctg gaa agc gta gtt gag tta ctg atc gag atc gcg 307 Ala Gly Ala Ser Leu Glu Ser Val Val Glu Leu Leu Ile Glu Ile Ala      55 60 65 ggc gcc gat tcc aat atc gcc caa gcc ctg cgc gga cat ttt gcc ttc 355 Gly Ala Asp Ser Asn Ile Ala Gln Ala Leu Arg Gly His Phe Ala Phe  70 75 80 85 gtg gaa cta ctc ctg gaa gcg ccg gag agc gaa ttc cgc acc cat tgg 403 Val Glu Leu Leu Leu Glu Ala Pro Glu Ser Glu Phe Arg Thr His Trp                  90 95 100 ctg cgc gaa gtc gcc acc gga aga ctt gtg ggc aac gcc gaa agt gag 451 Leu Arg Glu Val Ala Thr Gly Arg Leu Val Gly Asn Ala Glu Ser Glu             105 110 115 aaa cgc ggc gtt tac ggc gat ccg cag acc ttc atc gat gag gtg gag 499 Lys Arg Gly Val Tyr Gly Asp Pro Gln Thr Phe Ile Asp Glu Val Glu         120 125 130 act gaa aac gga ccg att ttc gtg ctc aac ggc act aag ttt tat acc 547 Thr Glu Asn Gly Pro Ile Phe Val Leu Asn Gly Thr Lys Phe Tyr Thr     135 140 145 acc ggc acc tat ttt gcg gac tac acc tgg acc acc gcg ctg ctg cgc 595 Thr Gly Thr Tyr Phe Ala Asp Tyr Thr Trp Thr Thr Ala Leu Leu Arg 150 155 160 165 aac ctt aac ggc caa gaa act ttg gtc agt ttg ccg gtc gat ctg cac 643 Asn Leu Asn Gly Gln Glu Thr Leu Val Ser Leu Pro Val Asp Leu His                 170 175 180 gcg ccg ggc gtg gat gtt gct gat gat tgg agc ggg ttt ggg caa aag 691 Ala Pro Gly Val Asp Val Ala Asp Asp Trp Ser Gly Phe Gly Gln Lys             185 190 195 ctc acc gcc tct gga acg acc acg ttt aaa gac ctg gag gtg gat ccg 739 Leu Thr Ala Ser Gly Thr Thr Thr Phe Lys Asp Leu Glu Val Asp Pro         200 205 210 cgg tgg atc att cca cgc act gat gcg ccc acg ctg gtg tgg acg tat 787 Arg Trp Ile Ile Pro Arg Thr Asp Ala Pro Thr Leu Val Trp Thr Tyr     215 220 225 ctg cag ctg agc ctg ctg acc gtg ctg gtt ggc agt gcc gca gca gct 835 Leu Gln Leu Ser Leu Leu Thr Val Leu Val Gly Ser Ala Ala Ala Ala 230 235 240 245 gtc gat gag gtg gtt gcc cgc gcc caa tcc tcc acc aga aat gcg tgg 883 Val Asp Glu Val Val Ala Arg Ala Gln Ser Ser Thr Arg Asn Ala Trp                 250 255 260 aac cct ggc gtc gag cgc cgc agc gat ccg gcc gca acc ata gcg atc 931 Asn Pro Gly Val Glu Arg Arg Ser Asp Pro Ala Ala Thr Ile Ala Ile             265 270 275 ggc gac gca cgc agc cga gtc acc gtt att cgt gga gcg ctt ctc gac 979 Gly Asp Ala Arg Ser Arg Val Thr Val Ile Arg Gly Ala Leu Leu Asp         280 285 290 gcc acc cgc cac gtt tcc aac gcc gcc acg atc gta acc ccc gaa gcc 1027 Ala Thr Arg His Val Ser Asn Ala Ala Thr Ile Val Thr Pro Glu Ala     295 300 305 ttc aac gag gcg gac gct att gtt gca gcg ctc tgg ccc atc gtc tcc 1075 Phe Asn Glu Ala Asp Ala Ile Val Ala Ala Leu Trp Pro Ile Val Ser 310 315 320 325 gga caa gct ttg gtg gtg aca tcc aac gtt ttc gat gcg gtg ggt gca 1123 Gly Gln Ala Leu Val Val Thr Ser Asn Val Phe Asp Ala Val Gly Ala                 330 335 340 tct gca gtg ctt ggt gag cat tcc att gat cgc cac tgg cgc aat gtg 1171 Ser Ala Val Leu Gly Glu His Ser Ile Asp Arg His Trp Arg Asn Val             345 350 355 cgt acc gtg tcc tca aac aac ccg gtg ttc ctg gcc aag aat gca gtg 1219 Arg Thr Val Ser Ser Asn Asn Pro Val Phe Leu Ala Lys Asn Ala Val         360 365 370 ggg gag tat gcc ctc aac ggc act cct gtg ggt acc aac att ggt aaa 1267 Gly Glu Tyr Ala Leu Asn Gly Thr Pro Val Gly Thr Asn Ile Gly Lys     375 380 385 gca ctg agc cgt ccg gtg agc cta agc agc tagacgtgtg atttcgctgg 1317 Ala Leu Ser Arg Pro Val Ser Leu Ser Ser 390 395 ttt 1320 <210> 160 <211> 399 <212> PRT <213> Corynebacterium glutamicum <400> 160 Met Ser Gln Glu Ile Leu Ser His Phe Ala Pro Ala Leu Glu Arg Ile   1 5 10 15 Arg Ser Gly Ala Val Glu Arg Glu Gln Gln Arg Ala Leu Pro Val Glu              20 25 30 Glu Ile Lys Glu Leu Val Glu Leu Gly Phe Thr Gly Leu Arg Val Pro          35 40 45 Glu Glu Leu Gly Gly Ala Gly Ala Ser Leu Glu Ser Val Val Glu Leu      50 55 60 Leu Ile Glu Ile Ala Gly Ala Asp Ser Asn Ile Ala Gln Ala Leu Arg  65 70 75 80 Gly His Phe Ala Phe Val Glu Leu Leu Leu Glu Ala Pro Glu Ser Glu                  85 90 95 Phe Arg Thr His Trp Leu Arg Glu Val Ala Thr Gly Arg Leu Val Gly             100 105 110 Asn Ala Glu Ser Glu Lys Arg Gly Val Tyr Gly Asp Pro Gln Thr Phe         115 120 125 Ile Asp Glu Val Glu Thr Glu Asn Gly Pro Ile Phe Val Leu Asn Gly     130 135 140 Thr Lys Phe Tyr Thr Thr Gly Thr Tyr Phe Ala Asp Tyr Thr Trp Thr 145 150 155 160 Thr Ala Leu Leu Arg Asn Leu Asn Gly Gln Glu Thr Leu Val Ser Leu                 165 170 175 Pro Val Asp Leu His Ala Pro Gly Val Asp Val Ala Asp Asp Trp Ser             180 185 190 Gly Phe Gly Gln Lys Leu Thr Ala Ser Gly Thr Thr Thr Phe Lys Asp         195 200 205 Leu Glu Val Asp Pro Arg Trp Ile Ile Pro Arg Thr Asp Ala Pro Thr     210 215 220 Leu Val Trp Thr Tyr Leu Gln Leu Ser Leu Leu Thr Val Leu Val Gly 225 230 235 240 Ser Ala Ala Ala Ala Val Asp Glu Val Val Ala Arg Ala Gln Ser Ser                 245 250 255 Thr Arg Asn Ala Trp Asn Pro Gly Val Glu Arg Arg Ser Asp Pro Ala             260 265 270 Ala Thr Ile Ala Ile Gly Asp Ala Arg Ser Arg Val Thr Val Ile Arg         275 280 285 Gly Ala Leu Leu Asp Ala Thr Arg His Val Ser Asn Ala Ala Thr Ile     290 295 300 Val Thr Pro Glu Ala Phe Asn Glu Ala Asp Ala Ile Val Ala Ala Leu 305 310 315 320 Trp Pro Ile Val Ser Gly Gln Ala Leu Val Val Thr Ser Asn Val Phe                 325 330 335 Asp Ala Val Gly Ala Ser Ala Val Leu Gly Glu His Ser Ile Asp Arg             340 345 350 His Trp Arg Asn Val Arg Thr Val Ser Ser Asn Asn Pro Val Phe Leu         355 360 365 Ala Lys Asn Ala Val Gly Glu Tyr Ala Leu Asn Gly Thr Pro Val Gly     370 375 380 Thr Asn Ile Gly Lys Ala Leu Ser Arg Pro Val Ser Leu Ser Ser 385 390 395 <210> 161 <211> 969 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (946) <223> RXN00931 <400> 161 ccgtaaccta atcgttgaaa catcacctta ttgctgggct ttgcacgcta ctctttgtga 60 gtaacctcac cgaagtgcat aaattaattg ggagtgatca gtg aaa act att gaa 115                                             Val Lys Thr Ile Glu                                               1 5 gat att ttg acc ttg gaa gaa atc gac cgc gat att tac cgt ggt ccc 163 Asp Ile Leu Thr Leu Glu Glu Ile Asp Arg Asp Ile Tyr Arg Gly Pro                  10 15 20 gtt atc gaa tct tat tta gcc agg act ttc ggt ggc cag gtc gct gcc 211 Val Ile Glu Ser Tyr Leu Ala Arg Thr Phe Gly Gly Gln Val Ala Ala              25 30 35 caa gct tta gta gca gca acg cat act gtt gat aaa gcc ttt act gtg 259 Gln Ala Leu Val Ala Ala Thr His Thr Val Asp Lys Ala Phe Thr Val          40 45 50 cat tct ttg cat ggc tac ttt ata gct cct ggt gat cca aca gca ccc 307 His Ser Leu His Gly Tyr Phe Ile Ala Pro Gly Asp Pro Thr Ala Pro      55 60 65 gca att tat tta gtg gat cga gtt cgc gac gga aaa agc tac gtc acc 355 Ala Ile Tyr Leu Val Asp Arg Val Arg Asp Gly Lys Ser Tyr Val Thr  70 75 80 85 cgc tcg gtg cgt ggc atc caa gac ggc gaa gta atc ttc agc atg cag 403 Arg Ser Val Arg Gly Ile Gln Asp Gly Glu Val Ile Phe Ser Met Gln                  90 95 100 gcc agc ttt cat cgt ggg gat gaa ggc att gag cac atg gac aag atg 451 Ala Ser Phe His Arg Gly Asp Glu Gly Ile Glu His Met Asp Lys Met             105 110 115 cgt aaa gtt cca gct cct gat gag atc aag gga aca gta gaa cgt atg 499 Arg Lys Val Pro Ala Pro Asp Glu Ile Lys Gly Thr Val Glu Arg Met         120 125 130 ccg atc tca agt agg cga gtg ctt gat gaa tgg gcg gaa tgg gat atc 547 Pro Ile Ser Ser Arg Arg Val Leu Asp Glu Trp Ala Glu Trp Asp Ile     135 140 145 cgc gtt att ccg cag gat caa tta gaa ctc agc gat ttc acc gct act 595 Arg Val Ile Pro Gln Asp Gln Leu Glu Leu Ser Asp Phe Thr Ala Thr 150 155 160 165 gag caa gct gtg tgg att cgg tgc acc gct gat ctt ccg gat aat ccc 643 Glu Gln Ala Val Trp Ile Arg Cys Thr Ala Asp Leu Pro Asp Asn Pro                 170 175 180 acc ttc cac cag tgc tca ctg act tat ctg tcc gat atg act ttg ctg 691 Thr Phe His Gln Cys Ser Leu Thr Tyr Leu Ser Asp Met Thr Leu Leu             185 190 195 cat agt gcc ctg gtg cca cac cca ggt gag aaa atg cag atg gcc tca 739 His Ser Ala Leu Val Pro His Pro Gly Glu Lys Met Gln Met Ala Ser         200 205 210 ctt gat cac gct gtg tgg ttc ctg cgt ccc ttc cgc gtc gat gaa tgg 787 Leu Asp His Ala Val Trp Phe Leu Arg Pro Phe Arg Val Asp Glu Trp     215 220 225 ttg ctt tat gat cag cgc tct cca tcg gcc tca agt ggg cga gcc ttg 835 Leu Leu Tyr Asp Gln Arg Ser Pro Ser Ala Ser Ser Gly Arg Ala Leu 230 235 240 245 act cac ggg cgg ctt ttc aac cag cag gga gat ttg gtc gct att gtc 883 Thr His Gly Arg Leu Phe Asn Gln Gln Gly Asp Leu Val Ala Ile Val                 250 255 260 aat caa gag gga atg acc cgc aca ctc cac gag ggt gcg caa tca att 931 Asn Gln Glu Gly Met Thr Arg Thr Leu His Glu Gly Ala Gln Ser Ile             265 270 275 ccg atg cgc aaa gac taaaatgcag cgaacttgaa gat 969 Pro Met Arg Lys Asp         280 <210> 162 <211> 282 <212> PRT <213> Corynebacterium glutamicum <400> 162 Val Lys Thr Ile Glu Asp Ile Leu Thr Leu Glu Glu Ile Asp Arg Asp   1 5 10 15 Ile Tyr Arg Gly Pro Val Ile Glu Ser Tyr Leu Ala Arg Thr Phe Gly              20 25 30 Gly Gln Val Ala Ala Gln Ala Leu Val Ala Ala Thr His Thr Val Asp          35 40 45 Lys Ala Phe Thr Val His Ser Leu His Gly Tyr Phe Ile Ala Pro Gly      50 55 60 Asp Pro Thr Ala Pro Ala Ile Tyr Leu Val Asp Arg Val Arg Asp Gly  65 70 75 80 Lys Ser Tyr Val Thr Arg Ser Val Arg Gly Ile Gln Asp Gly Glu Val                  85 90 95 Ile Phe Ser Met Gln Ala Ser Phe His Arg Gly Asp Glu Gly Ile Glu             100 105 110 His Met Asp Lys Met Arg Lys Val Pro Ala Pro Asp Glu Ile Lys Gly         115 120 125 Thr Val Glu Arg Met Pro Ile Ser Ser Arg Arg Val Leu Asp Glu Trp     130 135 140 Ala Glu Trp Asp Ile Arg Val Ile Pro Gln Asp Gln Leu Glu Leu Ser 145 150 155 160 Asp Phe Thr Ala Thr Glu Gln Ala Val Trp Ile Arg Cys Thr Ala Asp                 165 170 175 Leu Pro Asp Asn Pro Thr Phe His Gln Cys Ser Leu Thr Tyr Leu Ser             180 185 190 Asp Met Thr Leu Leu His Ser Ala Leu Val Pro His Pro Gly Glu Lys         195 200 205 Met Gln Met Ala Ser Leu Asp His Ala Val Trp Phe Leu Arg Pro Phe     210 215 220 Arg Val Asp Glu Trp Leu Leu Tyr Asp Gln Arg Ser Pro Ser Ala Ser 225 230 235 240 Ser Gly Arg Ala Leu Thr His Gly Arg Leu Phe Asn Gln Gln Gly Asp                 245 250 255 Leu Val Ala Ile Val Asn Gln Glu Gly Met Thr Arg Thr Leu His Glu             260 265 270 Gly Ala Gln Ser Ile Pro Met Arg Lys Asp         275 280 <210> 163 <211> 969 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (946) <223> FRXA00931 <400> 163 ccgtaaccta atcgttgaaa catcacctta ttgctgggct ttgcacgcta ctctttgtga 60 gtaacctcac cgaagtgcat aaattaattg ggagtgatca gtg aaa act att gaa 115                                             Val Lys Thr Ile Glu                                               1 5 gat att ttg acc ttg gaa gaa atc gac cgc gat att tac cgt ggt ccc 163 Asp Ile Leu Thr Leu Glu Glu Ile Asp Arg Asp Ile Tyr Arg Gly Pro                  10 15 20 gtt atc gaa tct tat tta gcc agg act ttc ggt ggc cag gtc gct gcc 211 Val Ile Glu Ser Tyr Leu Ala Arg Thr Phe Gly Gly Gln Val Ala Ala              25 30 35 caa gct tta gta gca gca acg cat act gtt gat aaa gcc ttt act gtg 259 Gln Ala Leu Val Ala Ala Thr His Thr Val Asp Lys Ala Phe Thr Val          40 45 50 cat tct ttg cat ggc tac ttt ata gct cct ggt gat cca aca gca ccc 307 His Ser Leu His Gly Tyr Phe Ile Ala Pro Gly Asp Pro Thr Ala Pro      55 60 65 gca att tat tta gtg gat cga gtt cgc gac gga aaa agc tac gtc acc 355 Ala Ile Tyr Leu Val Asp Arg Val Arg Asp Gly Lys Ser Tyr Val Thr  70 75 80 85 cgc tcg gtg cgt ggc atc caa gac ggc gaa gta atc ttc agc atg cag 403 Arg Ser Val Arg Gly Ile Gln Asp Gly Glu Val Ile Phe Ser Met Gln                  90 95 100 gcc agc ttt cat cgt ggg gat gaa ggc att gag cac atg gac aag atg 451 Ala Ser Phe His Arg Gly Asp Glu Gly Ile Glu His Met Asp Lys Met             105 110 115 cgt aaa gtt cca gct cct gat gag atc aag gga aca gta gaa cgt atg 499 Arg Lys Val Pro Ala Pro Asp Glu Ile Lys Gly Thr Val Glu Arg Met         120 125 130 ccg atc tca agt agg cga gtg ctt gat gaa tgg gcg gaa tgg gat atc 547 Pro Ile Ser Ser Arg Arg Val Leu Asp Glu Trp Ala Glu Trp Asp Ile     135 140 145 cgc gtt att ccg cag gat caa tta gaa ctc agc gat ttc acc gct act 595 Arg Val Ile Pro Gln Asp Gln Leu Glu Leu Ser Asp Phe Thr Ala Thr 150 155 160 165 gag caa gct gtg tgg att cgg tgc acc gct gat ctt ccg gat aat ccc 643 Glu Gln Ala Val Trp Ile Arg Cys Thr Ala Asp Leu Pro Asp Asn Pro                 170 175 180 acc ttc cac cag tgc tca ctg act tat ctg tcc gat atg act ttg ctg 691 Thr Phe His Gln Cys Ser Leu Thr Tyr Leu Ser Asp Met Thr Leu Leu             185 190 195 cat agt gcc ctg gtg cca cac cca ggt gag aaa atg cag atg gcc tca 739 His Ser Ala Leu Val Pro His Pro Gly Glu Lys Met Gln Met Ala Ser         200 205 210 ctt gat cac gct gtg tgg ttc ctg cgt ccc ttc cgc gtc gat gaa tgg 787 Leu Asp His Ala Val Trp Phe Leu Arg Pro Phe Arg Val Asp Glu Trp     215 220 225 ttg ctt tat gat cag cgc tct cca tcg gcc tca agt ggg cga gcc ttg 835 Leu Leu Tyr Asp Gln Arg Ser Pro Ser Ala Ser Ser Gly Arg Ala Leu 230 235 240 245 act cac ggg cgg ctt ttc aac cag cag gga gat ttg gtc gct att gtc 883 Thr His Gly Arg Leu Phe Asn Gln Gln Gly Asp Leu Val Ala Ile Val                 250 255 260 aat caa gag gga atg acc cgc aca ctc cac gag ggt gcg caa tca att 931 Asn Gln Glu Gly Met Thr Arg Thr Leu His Glu Gly Ala Gln Ser Ile             265 270 275 ccg atg cgc aaa gac taaaatgcag cgaacttgaa gat 969 Pro Met Arg Lys Asp         280 <210> 164 <211> 282 <212> PRT <213> Corynebacterium glutamicum <400> 164 Val Lys Thr Ile Glu Asp Ile Leu Thr Leu Glu Glu Ile Asp Arg Asp   1 5 10 15 Ile Tyr Arg Gly Pro Val Ile Glu Ser Tyr Leu Ala Arg Thr Phe Gly              20 25 30 Gly Gln Val Ala Ala Gln Ala Leu Val Ala Ala Thr His Thr Val Asp          35 40 45 Lys Ala Phe Thr Val His Ser Leu His Gly Tyr Phe Ile Ala Pro Gly      50 55 60 Asp Pro Thr Ala Pro Ala Ile Tyr Leu Val Asp Arg Val Arg Asp Gly  65 70 75 80 Lys Ser Tyr Val Thr Arg Ser Val Arg Gly Ile Gln Asp Gly Glu Val                  85 90 95 Ile Phe Ser Met Gln Ala Ser Phe His Arg Gly Asp Glu Gly Ile Glu             100 105 110 His Met Asp Lys Met Arg Lys Val Pro Ala Pro Asp Glu Ile Lys Gly         115 120 125 Thr Val Glu Arg Met Pro Ile Ser Ser Arg Arg Val Leu Asp Glu Trp     130 135 140 Ala Glu Trp Asp Ile Arg Val Ile Pro Gln Asp Gln Leu Glu Leu Ser 145 150 155 160 Asp Phe Thr Ala Thr Glu Gln Ala Val Trp Ile Arg Cys Thr Ala Asp                 165 170 175 Leu Pro Asp Asn Pro Thr Phe His Gln Cys Ser Leu Thr Tyr Leu Ser             180 185 190 Asp Met Thr Leu Leu His Ser Ala Leu Val Pro His Pro Gly Glu Lys         195 200 205 Met Gln Met Ala Ser Leu Asp His Ala Val Trp Phe Leu Arg Pro Phe     210 215 220 Arg Val Asp Glu Trp Leu Leu Tyr Asp Gln Arg Ser Pro Ser Ala Ser 225 230 235 240 Ser Gly Arg Ala Leu Thr His Gly Arg Leu Phe Asn Gln Gln Gly Asp                 245 250 255 Leu Val Ala Ile Val Asn Gln Glu Gly Met Thr Arg Thr Leu His Glu             260 265 270 Gly Ala Gln Ser Ile Pro Met Arg Lys Asp         275 280 <210> 165 <211> 510 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (101) .. (487) <223> RXN01421 <400> 165 ttgatgcacg tgcagaaatc gtcggcggtc cgtggcaccc atctgttaag ggagactcgg 60 ttactgcagg gatcctgcga gatcgagtaa acgcctaaag atg acg tcg aaa agc 115                                             Met Thr Ser Lys Ser                                               1 5 att agc ggc aag cgc ccg aat ctg ccg tcg ctc act gga gcg cgg tgg 163 Ile Ser Gly Lys Arg Pro Asn Leu Pro Ser Leu Thr Gly Ala Arg Trp                  10 15 20 ctc gcg gcg ctc gct gtt tat ttt ttg cat gcg ttg gtg ttt ttg tcg 211 Leu Ala Ala Leu Ala Val Tyr Phe Leu His Ala Leu Val Phe Leu Ser              25 30 35 gtg tat ccg ttc cag cag tcg gaa ctg ttt gcc aca atc cat aaa ttt 259 Val Tyr Pro Phe Gln Gln Ser Glu Leu Phe Ala Thr Ile His Lys Phe          40 45 50 gtc ccc atg cag ctg ggt tca gct ggt gta acc ttc ttc ttt atc ttg 307 Val Pro Met Gln Leu Gly Ser Ala Gly Val Thr Phe Phe Phe Ile Leu      55 60 65 tcc gga ttt ttg atc tat tgg tca aat agc cag ctc aag ggc atg aag 355 Ser Gly Phe Leu Ile Tyr Trp Ser Asn Ser Gln Leu Lys Gly Met Lys  70 75 80 85 aat gtg ctg tat tac tgc aag cgc cgc atc acc aag att tat ccc atg 403 Asn Val Leu Tyr Tyr Cys Lys Arg Arg Ile Thr Lys Ile Tyr Pro Met                  90 95 100 cac ttg att gcg ttg ccg atg ttt att gag gcg tcg gcg aag ttc acg 451 His Leu Ile Ala Leu Pro Met Phe Ile Glu Ala Ser Ala Lys Phe Thr             105 110 115 act aca ggc att acc tgg gtg ctg att ttg cgc gag taaagctgtg 497 Thr Thr Gly Ile Thr Trp Val Leu Ile Leu Arg Glu         120 125 gctgcggaat gcg 510 <210> 166 <211> 129 <212> PRT <213> Corynebacterium glutamicum <400> 166 Met Thr Ser Lys Ser Ile Ser Gly Lys Arg Pro Asn Leu Pro Ser Leu   1 5 10 15 Thr Gly Ala Arg Trp Leu Ala Ala Leu Ala Val Tyr Phe Leu His Ala              20 25 30 Leu Val Phe Leu Ser Val Tyr Pro Phe Gln Gln Ser Glu Leu Phe Ala          35 40 45 Thr Ile His Lys Phe Val Pro Met Gln Leu Gly Ser Ala Gly Val Thr      50 55 60 Phe Phe Phe Ile Leu Ser Gly Phe Leu Ile Tyr Trp Ser Asn Ser Gln  65 70 75 80 Leu Lys Gly Met Lys Asn Val Leu Tyr Tyr Cys Lys Arg Arg Ile Thr                  85 90 95 Lys Ile Tyr Pro Met His Leu Ile Ala Leu Pro Met Phe Ile Glu Ala             100 105 110 Ser Ala Lys Phe Thr Thr Thr Gly Ile Thr Trp Val Leu Ile Leu Arg         115 120 125 Glu <210> 167 <211> 930 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (907) <223> RXN02342 <400> 167 caggttcgtg ctgcgtgcgg gtagttttta aaggtaaaac tttttgggcg tgtcgccctt 60 aaagcgcgct tttcgacgcg accccactac attggcttcc atg aac gtt gac att 115                                             Met Asn Val Asp Ile                                               1 5 tca cga tcc aga gag ccg cta aac gtt gag ctc ctg aag gaa aaa ttg 163 Ser Arg Ser Arg Glu Pro Leu Asn Val Glu Leu Leu Lys Glu Lys Leu                  10 15 20 ctc caa aac ggt gac ttt ggc cag gtc att tac gaa aaa gtg aca ggc 211 Leu Gln Asn Gly Asp Phe Gly Gln Val Ile Tyr Glu Lys Val Thr Gly              25 30 35 tcc act aat gct gac ttg ctg gca ctt gca ggt tct ggc gct cca aac 259 Ser Thr Asn Ala Asp Leu Leu Ala Leu Ala Gly Ser Gly Ala Pro Asn          40 45 50 tgg acg gtg aaa act gtc gag ttt caa gat cat gcg cgt ggg cga ctc 307 Trp Thr Val Lys Thr Val Glu Phe Gln Asp His Ala Arg Gly Arg Leu      55 60 65 ggc cgc ccg tgg tct gcc cct gag ggt tcc caa aca atc gtg tct gtg 355 Gly Arg Pro Trp Ser Ala Pro Glu Gly Ser Gln Thr Ile Val Ser Val  70 75 80 85 ctc gtt caa cta tct att gat caa gtg gac cgg att ggc act att cca 403 Leu Val Gln Leu Ser Ile Asp Gln Val Asp Arg Ile Gly Thr Ile Pro                  90 95 100 ctc gcg gcg gga ctc gct gtc atg gat gcg ttg aat gac ctc ggt gtg 451 Leu Ala Ala Gly Leu Ala Val Met Asp Ala Leu Asn Asp Leu Gly Val             105 110 115 gaa ggt gcc gga ctg aaa tgg ccc aac gat gtt caa atc cac ggc aag 499 Glu Gly Ala Gly Leu Lys Trp Pro Asn Asp Val Gln Ile His Gly Lys         120 125 130 aaa ctc tgc ggc atc ctg gtg gaa gcc acc ggc ttt gat tcc acc cca 547 Lys Leu Cys Gly Ile Leu Val Glu Ala Thr Gly Phe Asp Ser Thr Pro     135 140 145 aca gtt gtc atc ggt tgg ggc act aat atc agc ctg act aaa gag gag 595 Thr Val Val Ile Gly Trp Gly Thr Asn Ile Ser Leu Thr Lys Glu Glu 150 155 160 165 ctt cct gtt cct cat gca act tcc ctc gca ttg gaa ggt gtt gaa gtc 643 Leu Pro Val Pro His Ala Thr Ser Leu Ala Leu Glu Gly Val Glu Val                 170 175 180 gac aga acc aca ttc ctt att aat atg ctc aca cat ctg cat act cga 691 Asp Arg Thr Thr Phe Leu Ile Asn Met Leu Thr His Leu His Thr Arg             185 190 195 ctg gac cag tgg cag ggt cca agt gtg gat tgg ctc gat gat tac cgt 739 Leu Asp Gln Trp Gln Gly Pro Ser Val Asp Trp Leu Asp Asp Tyr Arg         200 205 210 gcg gta tgt tcc agt att ggc caa gat gtt cga gtg ctt cta cct ggg 787 Ala Val Cys Ser Ser Ile Gly Gln Asp Val Arg Val Leu Leu Pro Gly     215 220 225 gat aaa gaa ctc tta ggt gaa gcg atc ggt gtc gcg act ggc gga gaa 835 Asp Lys Glu Leu Leu Gly Glu Ala Ile Gly Val Ala Thr Gly Gly Glu 230 235 240 245 att cgt gtt cgc gat gct tcg ggc acc gtt cac acc ctc aac gcc ggt 883 Ile Arg Val Arg Asp Ala Ser Gly Thr Val His Thr Leu Asn Ala Gly                 250 255 260 gaa att acg cac ctt cgc ctg cag taaggtgacg gtatggggaa ttc 930 Glu Ile Thr His Leu Arg Leu Gln             265 <210> 168 <211> 269 <212> PRT <213> Corynebacterium glutamicum <400> 168 Met Asn Val Asp Ile Ser Arg Ser Arg Glu Pro Leu Asn Val Glu Leu   1 5 10 15 Leu Lys Glu Lys Leu Leu Gln Asn Gly Asp Phe Gly Gln Val Ile Tyr              20 25 30 Glu Lys Val Thr Gly Ser Thr Asn Ala Asp Leu Leu Ala Leu Ala Gly          35 40 45 Ser Gly Ala Pro Asn Trp Thr Val Lys Thr Val Glu Phe Gln Asp His      50 55 60 Ala Arg Gly Arg Leu Gly Arg Pro Trp Ser Ala Pro Glu Gly Ser Gln  65 70 75 80 Thr Ile Val Ser Val Leu Val Gln Leu Ser Ile Asp Gln Val Asp Arg                  85 90 95 Ile Gly Thr Ile Pro Leu Ala Ala Gly Leu Ala Val Met Asp Ala Leu             100 105 110 Asn Asp Leu Gly Val Glu Gly Ala Gly Leu Lys Trp Pro Asn Asp Val         115 120 125 Gln Ile His Gly Lys Lys Leu Cys Gly Ile Leu Val Glu Ala Thr Gly     130 135 140 Phe Asp Ser Thr Pro Thr Val Val Ile Gly Trp Gly Thr Asn Ile Ser 145 150 155 160 Leu Thr Lys Glu Glu Leu Pro Val Pro His Ala Thr Ser Leu Ala Leu                 165 170 175 Glu Gly Val Glu Val Asp Arg Thr Thr Phe Leu Ile Asn Met Leu Thr             180 185 190 His Leu His Thr Arg Leu Asp Gln Trp Gln Gly Pro Ser Val Asp Trp         195 200 205 Leu Asp Asp Tyr Arg Ala Val Cys Ser Ser Ile Gly Gln Asp Val Arg     210 215 220 Val Leu Leu Pro Gly Asp Lys Glu Leu Leu Gly Glu Ala Ile Gly Val 225 230 235 240 Ala Thr Gly Gly Glu Ile Arg Val Arg Asp Ala Ser Gly Thr Val His                 245 250 255 Thr Leu Asn Ala Gly Glu Ile Thr His Leu Arg Leu Gln             260 265 <210> 169 <211> 2762 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (2739) <223> RXN00563 <400> 169 ttc tac aag gat ctc tac gca cgt tcc gca cgc ggc acg gca gca ctg 48 Phe Tyr Lys Asp Leu Tyr Ala Arg Ser Ala Arg Gly Thr Ala Ala Leu   1 5 10 15 tgg atc gtg gcg gct aac ttg agc tcc tac tca gac atc gac gcc atc 96 Trp Ile Val Ala Ala Asn Leu Ser Ser Tyr Ser Asp Ile Asp Ala Ile              20 25 30 atc aac tgg gtc gga tcc gag cag acc acc g gta aac ggc gca tcc 144 Ile Asn Trp Val Gly Ser Glu Gln Thr Thr Thr Thr Val Asn Gly Ala Ser          35 40 45 aag ctg gtc aag cca gct ttg gtc cct acc ttg ctg ttc cca ttc gcg 192 Lys Leu Val Lys Pro Ala Leu Val Pro Thr Leu Leu Phe Pro Phe Ala      50 55 60 gca cct cgc gtg tcc gga tcc atg gca gat gca ggc cca cag gca gaa 240 Ala Pro Arg Val Ser Gly Ser Met Ala Asp Ala Gly Pro Gln Ala Glu  65 70 75 80 tcc cag atg cga ctt ctg ctc tgg tct gtt gag cgc ctc atc gca ggt 288 Ser Gln Met Arg Leu Leu Leu Trp Ser Val Glu Arg Leu Ile Ala Gly                  85 90 95 ctt gcg cca ttg ggc tcc tcc atc aac gtg ggt cac cgc ctg cac gtg 336 Leu Ala Pro Leu Gly Ser Ser Ile Asn Val Gly His Arg Leu His Val             100 105 110 gtc atc cca ggt tca cca aac cgt gga cgc ttc ggt ggc gat ggt gca 384 Val Ile Pro Gly Ser Pro Asn Arg Gly Arg Phe Gly Gly Asp Gly Ala         115 120 125 tac ggt gaa tcc aag gca gct ctc gac gcc gtg gtt acc cgt tgg aac 432 Tyr Gly Glu Ser Lys Ala Ala Leu Asp Ala Val Val Thr Arg Trp Asn     130 135 140 gca gag caa gct gca tgg gga gca cac acc tcc ctc gtg cac gct cac 480 Ala Glu Gln Ala Ala Trp Gly Ala His Thr Ser Leu Val His Ala His 145 150 155 160 atc ggt tgg gtt cgc ggc acc ggc ctc atg ggc ggc aac gat cct ttg 528 Ile Gly Trp Val Arg Gly Thr Gly Leu Met Gly Gly Asn Asp Pro Leu                 165 170 175 gtc aag gca gct gaa gaa gca ggc gtg gaa acc tac tcc acc caa gaa 576 Val Lys Ala Ala Glu Glu Ala Gly Val Glu Thr Tyr Ser Thr Gln Glu             180 185 190 att gca gag aaa ctg ctg tcc cag gca act tcc act gtt cgc gag cag 624 Ile Ala Glu Lys Leu Leu Ser Gln Ala Thr Ser Thr Val Arg Glu Gln         195 200 205 gca gca tcc gcg cca atc acc gtc gac ttc act ggc gga ctt ggt gaa 672 Ala Ala Ser Ala Pro Ile Thr Val Asp Phe Thr Gly Gly Leu Gly Glu     210 215 220 tct gat ctg aac ctg gcg gaa atg gca cgt gca gaa gca gct aag gca 720 Ser Asp Leu Asn Leu Ala Glu Met Ala Arg Ala Glu Ala Ala Lys Ala 225 230 235 240 gct aac gca cca gtg gtt gag gct cca cgc aca gtg gca gca ctg cca 768 Ala Asn Ala Pro Val Val Glu Ala Pro Arg Thr Val Ala Ala Leu Pro                 245 250 255 act cct tac cga cca gtg gtt caa acc acc cct gat ttc gca ggt caa 816 Thr Pro Tyr Arg Pro Val Val Gln Thr Thr Pro Asp Phe Ala Gly Gln             260 265 270 gtc acc caa aac ctt gac gag atg gtc gtc atc gtt ggc gcc ggc gag 864 Val Thr Gln Asn Leu Asp Glu Met Val Val Ile Val Gly Ala Gly Glu         275 280 285 ctc ggc cca ctg ggt tct gca cgt acg cgt ttc gac gcc gaa ctc aac 912 Leu Gly Pro Leu Gly Ser Ala Arg Thr Arg Phe Asp Ala Glu Leu Asn     290 295 300 ggt tcc ctc tcc gcc gcg ggt gtc atc gaa ctt gca tgg acg atg gga 960 Gly Ser Leu Ser Ala Ala Gly Val Ile Glu Leu Ala Trp Thr Met Gly 305 310 315 320 ctt atc cac tgg gat gaa gat cca aag cca ggc tgg tac gac gac tcc 1008 Leu Ile His Trp Asp Glu Asp Pro Lys Pro Gly Trp Tyr Asp Asp Ser                 325 330 335 gac gac gca gtg gcc gaa gaa gac atc ttc gac cgc tac cac gac gaa 1056 Asp Asp Ala Val Ala Glu Glu Asp Ile Phe Asp Arg Tyr His Asp Glu             340 345 350 gtc atg gca cgc gtt ggt gtc cgc aag tac aat gac atg cct gag tac 1104 Val Met Ala Arg Val Gly Val Arg Lys Tyr Asn Asp Met Pro Glu Tyr         355 360 365 ggc atg atc gac aac ttt gca cca gag ctg acc acc gtc tac ctc gac 1152 Gly Met Ile Asp Asn Phe Ala Pro Glu Leu Thr Thr Val Tyr Leu Asp     370 375 380 cag gac ctc acc ttc aac gtg gga tcc cgc gaa gag gca ctg acc tac 1200 Gln Asp Leu Thr Phe Asn Val Gly Ser Arg Glu Glu Ala Leu Thr Tyr 385 390 395 400 gtc gac tcc gag cca gaa ctc acc ttt gct tct ttc gac gaa gca gca 1248 Val Asp Ser Glu Pro Glu Leu Thr Phe Ala Ser Phe Asp Glu Ala Ala                 405 410 415 ggg gag tgg aag gtc act cgc aag gca ggc tcc gca atc cgc gta cct 1296 Gly Glu Trp Lys Val Thr Arg Lys Ala Gly Ser Ala Ile Arg Val Pro             420 425 430 cgc cgc atg gcg atg acc cgc ttc gtt ggt gga cag gtt cct aag gac 1344 Arg Arg Met Ala Met Thr Arg Phe Val Gly Gly Gln Val Pro Lys Asp         435 440 445 ttc gac cca gct gtg tgg ggc att cca gct gac atg gtg gac aac ctg 1392 Phe Asp Pro Ala Val Trp Gly Ile Pro Ala Asp Met Val Asp Asn Leu     450 455 460 gac acc gtc gcg ctg tgg aac att gtc tgt act gtc gac gcc ttc ctg 1440 Asp Thr Val Ala Leu Trp Asn Ile Val Cys Thr Val Asp Ala Phe Leu 465 470 475 480 tcc gct gga ttc acc cca gca gag ctg ctt gct tcc gtt cac cca gca 1488 Ser Ala Gly Phe Thr Pro Ala Glu Leu Leu Ala Ser Val His Pro Ala                 485 490 495 cgc gtg tcc tct acc caa ggc acc ggc atg ggc ggc atg gaa tcc ctc 1536 Arg Val Ser Ser Thr Gln Gly Thr Gly Met Gly Gly Met Glu Ser Leu             500 505 510 cgt ggc atc tac gtc gac cgc att ctg gca gag cca cgc gcc aac gac 1584 Arg Gly Ile Tyr Val Asp Arg Ile Leu Ala Glu Pro Arg Ala Asn Asp         515 520 525 gtt ctg cag gaa gca ctg ccc aac gtt gtt gca gct cac gtc atg cag 1632 Val Leu Gln Glu Ala Leu Pro Asn Val Val Ala Ala His Val Met Gln     530 535 540 tcc tac gtc ggt ggc tac gga cag atg atc cac cca gtc gca gct tgt 1680 Ser Tyr Val Gly Gly Tyr Gly Gln Met Ile His Pro Val Ala Ala Cys 545 550 555 560 gca acc gca gct gtt tct gtg gaa gaa gca ctg gac aag atc cgc atc 1728 Ala Thr Ala Ala Val Ser Val Glu Glu Ala Leu Asp Lys Ile Arg Ile                 565 570 575 ggc aag tcc gac ttc gtt gtc gca ggt ggc ttc gat gcc ctg tcc gtt 1776 Gly Lys Ser Asp Phe Val Val Ala Gly Gly Phe Asp Ala Leu Ser Val             580 585 590 gaa ggc atc acc ggc ttc ggc gac atg gca gca acc gcc gac tcc gca 1824 Glu Gly Ile Thr Gly Phe Gly Asp Met Ala Ala Thr Ala Asp Ser Ala         595 600 605 gag atg gaa ggc aag gga att gag cac cgc ttc ttc tcc cgc gcc aac 1872 Glu Met Glu Gly Lys Gly Ile Glu His Arg Phe Phe Ser Arg Ala Asn     610 615 620 gac cgg cgc cgc ggt gga ttc atc gaa tcc gaa ggt ggc gga acc gtc 1920 Asp Arg Arg Arg Gly Gly Phe Ile Glu Ser Glu Gly Gly Gly Thr Val 625 630 635 640 ctt ctg gca cgc gga tca ctc gca gct gac ctg ggc ctt cca gta ctc 1968 Leu Leu Ala Arg Gly Ser Leu Ala Ala Asp Leu Gly Leu Pro Val Leu                 645 650 655 ggt gtc atc gga ttc gca gag tcc ttt gca gat ggt gcc cac acc tcc 2016 Gly Val Ile Gly Phe Ala Glu Ser Phe Ala Asp Gly Ala His Thr Ser             660 665 670 atc cca gcc cca ggc ctc ggt gcc ctt ggt gct gct cgc gat ggt gtg 2064 Ile Pro Ala Pro Gly Leu Gly Ala Leu Gly Ala Ala Arg Asp Gly Val         675 680 685 gaa tct cgc ctt gca gta gca ctg cgt tcc gtc ggt gtc tct gct gat 2112 Glu Ser Arg Leu Ala Val Ala Leu Arg Ser Val Gly Val Ser Ala Asp     690 695 700 gag atc tcc att atc tcc aag cac gac acc tcc acc aac gcg aat gat 2160 Glu Ile Ser Ile Ile Ser Lys His Asp Thr Ser Thr Asn Ala Asn Asp 705 710 715 720 cca aac gag tcc gac ctg cac gag cgc atc gca tcc gct atc ggt cgt 2208 Pro Asn Glu Ser Asp Leu His Glu Arg Ile Ala Ser Ala Ile Gly Arg                 725 730 735 gca gac ggc aac ccg atg tac gtg att tcc cag aag tca ctc acc gga 2256 Ala Asp Gly Asn Pro Met Tyr Val Ile Ser Gln Lys Ser Leu Thr Gly             740 745 750 cac gcc aag ggt ggt gca gca gca ttc cag atg atc ggt ctc acc cag 2304 His Ala Lys Gly Gly Ala Ala Ala Phe Gln Met Ile Gly Leu Thr Gln         755 760 765 gtc ctc cga tcc gga ctg gtg cca gcc aac cgc gca ctc gac tgc gtt 2352 Val Leu Arg Ser Gly Leu Val Pro Ala Asn Arg Ala Leu Asp Cys Val     770 775 780 gac cca gta ctg tcc aag cat tcc cac ctc gtc tgg ctg cgc aag cca 2400 Asp Pro Val Leu Ser Lys His Ser His Leu Val Trp Leu Arg Lys Pro 785 790 795 800 cta gac ctt cgt gcg aag gca cca aag gca ggt ctt gtt acc tcc ctt 2448 Leu Asp Leu Arg Ala Lys Ala Pro Lys Ala Gly Leu Val Thr Ser Leu                 805 810 815 ggc ttc gga cac gtc tcc gct ctg gtt gcg att gtt cac cca gac gcc 2496 Gly Phe Gly His Val Ser Ala Leu Val Ala Ile Val His Pro Asp Ala             820 825 830 ttc tat gag gca gtt cgt gtg gca cgt ggt gct gag gca gct gac gta 2544 Phe Tyr Glu Ala Val Arg Val Ala Arg Gly Ala Glu Ala Ala Asp Val         835 840 845 tgg cgc gca tcc gcg atc gct cgc gaa gaa gca ggc ctt cgt acc atc 2592 Trp Arg Ala Ser Ala Ile Ala Arg Glu Glu Ala Gly Leu Arg Thr Ile     850 855 860 gtc gcc ggt atg cac ggt ggc gta ctg tac gaa cgc cca gtc gag cgc 2640 Val Ala Gly Met His Gly Gly Val Leu Tyr Glu Arg Pro Val Glu Arg 865 870 875 880 aac ctc ggt gtc cac gga gac gca gct aag gaa gtt gaa gct gca gtc 2688 Asn Leu Gly Val His Gly Asp Ala Ala Lys Glu Val Glu Ala Ala Val                 885 890 895 ctc ctg gat tcc cgc gcc cgc cta gtt gac ggt gtc ctc cgc gcc gaa 2736 Leu Leu Asp Ser Arg Ala Arg Leu Val Asp Gly Val Leu Arg Ala Glu             900 905 910 ggc tagttggtta ttgcgttgag ccc 2762 Gly <210> 170 <211> 913 <212> PRT <213> Corynebacterium glutamicum <400> 170 Phe Tyr Lys Asp Leu Tyr Ala Arg Ser Ala Arg Gly Thr Ala Ala Leu   1 5 10 15 Trp Ile Val Ala Ala Asn Leu Ser Ser Tyr Ser Asp Ile Asp Ala Ile              20 25 30 Ile Asn Trp Val Gly Ser Glu Gln Thr Thr Thr Thr Val Asn Gly Ala Ser          35 40 45 Lys Leu Val Lys Pro Ala Leu Val Pro Thr Leu Leu Phe Pro Phe Ala      50 55 60 Ala Pro Arg Val Ser Gly Ser Met Ala Asp Ala Gly Pro Gln Ala Glu  65 70 75 80 Ser Gln Met Arg Leu Leu Leu Trp Ser Val Glu Arg Leu Ile Ala Gly                  85 90 95 Leu Ala Pro Leu Gly Ser Ser Ile Asn Val Gly His Arg Leu His Val             100 105 110 Val Ile Pro Gly Ser Pro Asn Arg Gly Arg Phe Gly Gly Asp Gly Ala         115 120 125 Tyr Gly Glu Ser Lys Ala Ala Leu Asp Ala Val Val Thr Arg Trp Asn     130 135 140 Ala Glu Gln Ala Ala Trp Gly Ala His Thr Ser Leu Val His Ala His 145 150 155 160 Ile Gly Trp Val Arg Gly Thr Gly Leu Met Gly Gly Asn Asp Pro Leu                 165 170 175 Val Lys Ala Ala Glu Glu Ala Gly Val Glu Thr Tyr Ser Thr Gln Glu             180 185 190 Ile Ala Glu Lys Leu Leu Ser Gln Ala Thr Ser Thr Val Arg Glu Gln         195 200 205 Ala Ala Ser Ala Pro Ile Thr Val Asp Phe Thr Gly Gly Leu Gly Glu     210 215 220 Ser Asp Leu Asn Leu Ala Glu Met Ala Arg Ala Glu Ala Ala Lys Ala 225 230 235 240 Ala Asn Ala Pro Val Val Glu Ala Pro Arg Thr Val Ala Ala Leu Pro                 245 250 255 Thr Pro Tyr Arg Pro Val Val Gln Thr Thr Pro Asp Phe Ala Gly Gln             260 265 270 Val Thr Gln Asn Leu Asp Glu Met Val Val Ile Val Gly Ala Gly Glu         275 280 285 Leu Gly Pro Leu Gly Ser Ala Arg Thr Arg Phe Asp Ala Glu Leu Asn     290 295 300 Gly Ser Leu Ser Ala Ala Gly Val Ile Glu Leu Ala Trp Thr Met Gly 305 310 315 320 Leu Ile His Trp Asp Glu Asp Pro Lys Pro Gly Trp Tyr Asp Asp Ser                 325 330 335 Asp Asp Ala Val Ala Glu Glu Asp Ile Phe Asp Arg Tyr His Asp Glu             340 345 350 Val Met Ala Arg Val Gly Val Arg Lys Tyr Asn Asp Met Pro Glu Tyr         355 360 365 Gly Met Ile Asp Asn Phe Ala Pro Glu Leu Thr Thr Val Tyr Leu Asp     370 375 380 Gln Asp Leu Thr Phe Asn Val Gly Ser Arg Glu Glu Ala Leu Thr Tyr 385 390 395 400 Val Asp Ser Glu Pro Glu Leu Thr Phe Ala Ser Phe Asp Glu Ala Ala                 405 410 415 Gly Glu Trp Lys Val Thr Arg Lys Ala Gly Ser Ala Ile Arg Val Pro             420 425 430 Arg Arg Met Ala Met Thr Arg Phe Val Gly Gly Gln Val Pro Lys Asp         435 440 445 Phe Asp Pro Ala Val Trp Gly Ile Pro Ala Asp Met Val Asp Asn Leu     450 455 460 Asp Thr Val Ala Leu Trp Asn Ile Val Cys Thr Val Asp Ala Phe Leu 465 470 475 480 Ser Ala Gly Phe Thr Pro Ala Glu Leu Leu Ala Ser Val His Pro Ala                 485 490 495 Arg Val Ser Ser Thr Gln Gly Thr Gly Met Gly Gly Met Glu Ser Leu             500 505 510 Arg Gly Ile Tyr Val Asp Arg Ile Leu Ala Glu Pro Arg Ala Asn Asp         515 520 525 Val Leu Gln Glu Ala Leu Pro Asn Val Val Ala Ala His Val Met Gln     530 535 540 Ser Tyr Val Gly Gly Tyr Gly Gln Met Ile His Pro Val Ala Ala Cys 545 550 555 560 Ala Thr Ala Ala Val Ser Val Glu Glu Ala Leu Asp Lys Ile Arg Ile                 565 570 575 Gly Lys Ser Asp Phe Val Val Ala Gly Gly Phe Asp Ala Leu Ser Val             580 585 590 Glu Gly Ile Thr Gly Phe Gly Asp Met Ala Ala Thr Ala Asp Ser Ala         595 600 605 Glu Met Glu Gly Lys Gly Ile Glu His Arg Phe Phe Ser Arg Ala Asn     610 615 620 Asp Arg Arg Arg Gly Gly Phe Ile Glu Ser Glu Gly Gly Gly Thr Val 625 630 635 640 Leu Leu Ala Arg Gly Ser Leu Ala Ala Asp Leu Gly Leu Pro Val Leu                 645 650 655 Gly Val Ile Gly Phe Ala Glu Ser Phe Ala Asp Gly Ala His Thr Ser             660 665 670 Ile Pro Ala Pro Gly Leu Gly Ala Leu Gly Ala Ala Arg Asp Gly Val         675 680 685 Glu Ser Arg Leu Ala Val Ala Leu Arg Ser Val Gly Val Ser Ala Asp     690 695 700 Glu Ile Ser Ile Ile Ser Lys His Asp Thr Ser Thr Asn Ala Asn Asp 705 710 715 720 Pro Asn Glu Ser Asp Leu His Glu Arg Ile Ala Ser Ala Ile Gly Arg                 725 730 735 Ala Asp Gly Asn Pro Met Tyr Val Ile Ser Gln Lys Ser Leu Thr Gly             740 745 750 His Ala Lys Gly Gly Ala Ala Ala Phe Gln Met Ile Gly Leu Thr Gln         755 760 765 Val Leu Arg Ser Gly Leu Val Pro Ala Asn Arg Ala Leu Asp Cys Val     770 775 780 Asp Pro Val Leu Ser Lys His Ser His Leu Val Trp Leu Arg Lys Pro 785 790 795 800 Leu Asp Leu Arg Ala Lys Ala Pro Lys Ala Gly Leu Val Thr Ser Leu                 805 810 815 Gly Phe Gly His Val Ser Ala Leu Val Ala Ile Val His Pro Asp Ala             820 825 830 Phe Tyr Glu Ala Val Arg Val Ala Arg Gly Ala Glu Ala Ala Asp Val         835 840 845 Trp Arg Ala Ser Ala Ile Ala Arg Glu Glu Ala Gly Leu Arg Thr Ile     850 855 860 Val Ala Gly Met His Gly Gly Val Leu Tyr Glu Arg Pro Val Glu Arg 865 870 875 880 Asn Leu Gly Val His Gly Asp Ala Ala Lys Glu Val Glu Ala Ala Val                 885 890 895 Leu Leu Asp Ser Arg Ala Arg Leu Val Asp Gly Val Leu Arg Ala Glu             900 905 910 Gly <210> 171 <211> 2937 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (101) .. (2914) <223> RXN02168 <400> 171 agggtttagt catctatttc ggctacgctc acgtaaccta cgcattcgta agtggtcatg 60 ggtccaagaa gcccattcca agacttagga gctttatttc gtg agt att tct tca 115                                             Val Ser Ile Ser Ser                                               1 5 ctg aca ccg ctg cac tct ttc aaa gag cca gca att ctg tac gcc ggt 163 Leu Thr Pro Leu His Ser Phe Lys Glu Pro Ala Ile Leu Tyr Ala Gly                  10 15 20 cag gct tct gcc tgg cag cag gtg atc gct gat tcc agc gaa gac cac 211 Gln Ala Ser Ala Trp Gln Gln Val Ile Ala Asp Ser Ser Glu Asp His              25 30 35 atc acc gca acg cac ctg cgc gag ctc ctg tct cgc tcc cgt gca aag 259 Ile Thr Ala Thr His Leu Arg Glu Leu Leu Ser Arg Ser Arg Ala Lys          40 45 50 act gca cct ttc gct cgc caa atc acc gcc atc gtg cct ggc tca ctt 307 Thr Ala Pro Phe Ala Arg Gln Ile Thr Ala Ile Val Pro Gly Ser Leu      55 60 65 gct cgt ctt gag gaa ctg acc cgc gaa gac gca caa atc ggt gca gac 355 Ala Arg Leu Glu Glu Leu Thr Arg Glu Asp Ala Gln Ile Gly Ala Asp  70 75 80 85 atc gac gca cag cct gcc gtt tcc att cca ggc att ctg ctg gga cag 403 Ile Asp Ala Gln Pro Ala Val Ser Ile Pro Gly Ile Leu Leu Gly Gln                  90 95 100 atc gct gca acc cgt cag ctg cgt gac ctc gga ctc gat gtc gca gca 451 Ile Ala Ala Thr Arg Gln Leu Arg Asp Leu Gly Leu Asp Val Ala Ala             105 110 115 gct tcc cgc ctt gga cac tcc cag ggc att ttg ggc gtt gaa gca gta 499 Ala Ser Arg Leu Gly His Ser Gln Gly Ile Leu Gly Val Glu Ala Val         120 125 130 gac aat gaa gaa gac gtt tta gct ttc gcc atc ctg ctg ggc gca gca 547 Asp Asn Glu Glu Asp Val Leu Ala Phe Ala Ile Leu Leu Gly Ala Ala     135 140 145 gct tcc cag ttc gct ggc aag ggc gca cat atg ctc tct gtt cgc ggc 595 Ala Ser Gln Phe Ala Gly Lys Gly Ala His Met Leu Ser Val Arg Gly 150 155 160 165 ctg tcc cgt gag atc atc cag gac acc atc gct ggt gtc gat ggg gta 643 Leu Ser Arg Glu Ile Ile Gln Asp Thr Ile Ala Gly Val Asp Gly Val                 170 175 180 gag gtc tcc ctg cgc aac gct cgt gca cac ttt gtt gtc tct ggt aag 691 Glu Val Ser Leu Arg Asn Ala Arg Ala His Phe Val Val Ser Gly Lys             185 190 195 cca gag gca ctg aag aag gct gct gct gct cta cag cgc gca gct gat 739 Pro Glu Ala Leu Lys Lys Lys Ala Ala Ala Ala Leu Gln Arg Ala Ala Asp         200 205 210 gtt tac aac gaa gac atc aac gaa aag cgc aag ggt gga tcc ctg gca 787 Val Tyr Asn Glu Asp Ile Asn Glu Lys Arg Lys Gly Gly Ser Leu Ala     215 220 225 gag cct aag ttt gac tac ttg gat gtg gcc att cct ttc cac cac tcc 835 Glu Pro Lys Phe Asp Tyr Leu Asp Val Ala Ile Pro Phe His His Ser 230 235 240 245 tcc atg cag gac gca gcc gac ttg gct gtc gag tgg gca acc acc tgt 883 Ser Met Gln Asp Ala Ala Asp Leu Ala Val Glu Trp Ala Thr Thr Cys                 250 255 260 ggc cta aac gtc aac gcg cgc gcg ttg gca gaa gca att cta gtt aac 931 Gly Leu Asn Val Asn Ala Arg Ala Leu Ala Glu Ala Ile Leu Val Asn             265 270 275 cca gct gac tgg gtt gag cag atc gca aac ctc aag gct gat tac gtt 979 Pro Ala Asp Trp Val Glu Gln Ile Ala Asn Leu Lys Ala Asp Tyr Val         280 285 290 ctt tcc ctc gat gca ggc gtc agc cgt ttc acc gct cca ttg cta gac 1027 Leu Ser Leu Asp Ala Gly Val Ser Arg Phe Thr Ala Pro Leu Leu Asp     295 300 305 ggt cgc gga atc tct ttg gtt cct gcg ttc tcc gct gca gag cgc gac 1075 Gly Arg Gly Ile Ser Leu Val Pro Ala Phe Ser Ala Ala Glu Arg Asp 310 315 320 325 aac ttg gct cgc cct ggc ttc cac gtt cct acc gct gag gat tgg tcc 1123 Asn Leu Ala Arg Pro Gly Phe His Val Pro Thr Ala Glu Asp Trp Ser                 330 335 340 gag ttc gct cca aag ctg gtt aag ctt cca aac ggt gag cac aag gtt 1171 Glu Phe Ala Pro Lys Leu Val Lys Leu Pro Asn Gly Glu His Lys Val             345 350 355 ctc acc ggg ttc tcc cgc ctg act ggt tat tcc cca atc gtc ctg gct 1219 Leu Thr Gly Phe Ser Arg Leu Thr Gly Tyr Ser Pro Ile Val Leu Ala         360 365 370 ggc atg acc cca acc acc gtt gat cct gag atc gtt gca gct gca gcg 1267 Gly Met Thr Pro Thr Thr Val Asp Pro Glu Ile Val Ala Ala Ala Ala     375 380 385 aac gct gga cac tgg gcc gaa atg gcc ggt ggc gga cag tac tct gaa 1315 Asn Ala Gly His Trp Ala Glu Met Ala Gly Gly Gly Gln Tyr Ser Glu 390 395 400 405 gaa gtc ttc acc aag aac aag gaa aag ctc gtt tcc ctg ctc aag gtt 1363 Glu Val Phe Thr Lys Asn Lys Glu Lys Leu Val Ser Leu Leu Lys Val                 410 415 420 gga cgc tcc gca cag ttc aac tcc atg ttc ttc gac cgc tac atg tgg 1411 Gly Arg Ser Ala Gln Phe Asn Ser Met Phe Phe Asp Arg Tyr Met Trp             425 430 435 aac ctg cag ttc ggt gca cag cgc atc gtt tcc aag gca cgt gca acc 1459 Asn Leu Gln Phe Gly Ala Gln Arg Ile Val Ser Lys Ala Arg Ala Thr         440 445 450 ggt acc tcc atc aac ggt gtt gtt gtc tcc gct ggt atc cca gag gtt 1507 Gly Thr Ser Ile Asn Gly Val Val Val Ser Ala Gly Ile Pro Glu Val     455 460 465 gag gaa gca act gag ctg atc aac gat ctg aac gct gat ggc ttc cca 1555 Glu Glu Ala Thr Glu Leu Ile Asn Asp Leu Asn Ala Asp Gly Phe Pro 470 475 480 485 tac gtt gca ttc aag cca ggc acc gtg gat cag atc cgc gca acc ctg 1603 Tyr Val Ala Phe Lys Pro Gly Thr Val Asp Gln Ile Arg Ala Thr Leu                 490 495 500 aag att gct gat gca aac cca gag acc aag atc atc atc cag atc gag 1651 Lys Ile Ala Asp Ala Asn Pro Glu Thr Lys Ile Ile Ile Gln Ile Glu             505 510 515 gac gga cac gct ggt ggc cac cac tcc tgg gtc aac ttg gac gat ctg 1699 Asp Gly His Ala Gly Gly His His Ser Trp Val Asn Leu Asp Asp Leu         520 525 530 ctc ctg acc acc tac gca gag ctg cgt tcc cgc aag aac gtt gtc gtc 1747 Leu Leu Thr Thr Tyr Ala Glu Leu Arg Ser Arg Lys Asn Val Val Val     535 540 545 atg atc ggt ggc ggc atc gga acc cct gca aag gct gct tac tac ctg 1795 Met Ile Gly Gly Gly Ile Gly Thr Pro Ala Lys Ala Ala Tyr Tyr Leu 550 555 560 565 acc ggt gaa tgg tcc acc gat ttg ggc ttc cca gca atg cca gtg gac 1843 Thr Gly Glu Trp Ser Thr Asp Leu Gly Phe Pro Ala Met Pro Val Asp                 570 575 580 ggc atc ctc gtg ggt acc gct gcc atg gca acc aag gaa gca acc act 1891 Gly Ile Leu Val Gly Thr Ala Ala Met Ala Thr Lys Glu Ala Thr Thr             585 590 595 tct cct cag gtc aag cag gca ctg gtc gac acc cca ggt gtt gat cca 1939 Ser Pro Gln Val Lys Gln Ala Leu Val Asp Thr Pro Gly Val Asp Pro         600 605 610 cac gac gct ggc ggc tgg gtt ggc cgt ggc gat gct cgt ggt ggc gtg 1987 His Asp Ala Gly Gly Trp Val Gly Arg Gly Asp Ala Arg Gly Gly Val     615 620 625 acc tct ggt ctg tca cac ctg cac gct gac atg tac gag ctg gac aac 2035 Thr Ser Gly Leu Ser His Leu His Ala Asp Met Tyr Glu Leu Asp Asn 630 635 640 645 gat tct gct gca gct tcc cgc ctg atc tct tcc atc gat tct gat gat 2083 Asp Ser Ala Ala Ala Ser Arg Leu Ile Ser Ser Ile Asp Ser Asp Asp                 650 655 660 tac gca gat cac cgc gaa gag ctc atc gag gct atc aac aag acc gct 2131 Tyr Ala Asp His Arg Glu Glu Leu Ile Glu Ala Ile Asn Lys Thr Ala             665 670 675 aag cct ttc ttc ggc gag gtc gaa gag atg act tac gca gag tgg atc 2179 Lys Pro Phe Phe Gly Glu Val Glu Glu Met Thr Tyr Ala Glu Trp Ile         680 685 690 cag cgt tgg gtt gag ctt gct tac cca act cag gac cca acc tgg gat 2227 Gln Arg Trp Val Glu Leu Ala Tyr Pro Thr Gln Asp Pro Thr Trp Asp     695 700 705 gat cgt ttc ctc gat ttg gtt cac cgc att gaa gct cgt ctc aac gag 2275 Asp Arg Phe Leu Asp Leu Val His Arg Ile Glu Ala Arg Leu Asn Glu 710 715 720 725 gca gag cac ggc gcc atc acc aca ctg ttc cca gac cat gcg tct gtg 2323 Ala Glu His Gly Ala Ile Thr Thr Leu Phe Pro Asp His Ala Ser Val                 730 735 740 gaa aat gag gaa gag gcc gtc gaa aag ctt ctt gct gct tac ccg cag 2371 Glu Asn Glu Glu Glu Ala Val Glu Lys Leu Leu Ala Ala Tyr Pro Gln             745 750 755 gcc cgc gag atc cag gtc tct gcg cgc gac gcc gcg tgg ttt att ggt 2419 Ala Arg Glu Ile Gln Val Ser Ala Arg Asp Ala Ala Trp Phe Ile Gly         760 765 770 ctg tgc cgc aag cac cac aag cct atg cct tgg gtt cca gca atc gat 2467 Leu Cys Arg Lys His His Lys Pro Met Pro Trp Val Pro Ala Ile Asp     775 780 785 gct gac cta gca cgc tgg tgg ggc ctt gac acc ctg tgg cag tcc cag 2515 Ala Asp Leu Ala Arg Trp Trp Gly Leu Asp Thr Leu Trp Gln Ser Gln 790 795 800 805 aac gag cgc tac ggc gcg aac tca gtc cgc gtt atc cca gga cca gtc 2563 Asn Glu Arg Tyr Gly Ala Asn Ser Val Arg Val Ile Pro Gly Pro Val                 810 815 820 tcc gtc gcc ggc atc gac cgt gtt gac gag cca gtt gca gag ctg ctc 2611 Ser Val Ala Gly Ile Asp Arg Val Asp Glu Pro Val Ala Glu Leu Leu             825 830 835 ggc cgc ttc gaa gct gcc tgc gtt gac gct ctc gac ggc gag cca gaa 2659 Gly Arg Phe Glu Ala Ala Cys Val Asp Ala Leu Asp Gly Glu Pro Glu         840 845 850 gag atc ttc gct cgc ctc aat gag tcc aag aac gag cgc gaa ttc ctg 2707 Glu Ile Phe Ala Arg Leu Asn Glu Ser Lys Asn Glu Arg Glu Phe Leu     855 860 865 ctg gct acc cca cac atc gtg tgg cac ggc aac ctg atc gac aac cca 2755 Leu Ala Thr Pro His Ile Val Trp His Gly Asn Leu Ile Asp Asn Pro 870 875 880 885 gct cac gtc ctc aac gag ggt gct ttc gag ctc atc gag gag gat ggc 2803 Ala His Val Leu Asn Glu Gly Ala Phe Glu Leu Ile Glu Glu Asp Gly                 890 895 900 tac tgg gtc atc cgt atc ctg gct gat tcc tac ttc gac gat ctg cca 2851 Tyr Trp Val Ile Arg Ile Leu Ala Asp Ser Tyr Phe Asp Asp Leu Pro             905 910 915 gtt gag cag cgc cca tac ctg gtt cag cat gtt gac atc cca gtt gag 2899 Val Glu Gln Arg Pro Tyr Leu Val Gln His Val Asp Ile Pro Val Glu         920 925 930 ctg ggt gac gct ggt tgaaccggtg gtttcccaat tgg 2937 Leu Gly Asp Ala Gly     935 <210> 172 <211> 938 <212> PRT <213> Corynebacterium glutamicum <400> 172 Val Ser Ile Ser Ser Leu Thr Pro Leu His Ser Phe Lys Glu Pro Ala   1 5 10 15 Ile Leu Tyr Ala Gly Gln Ala Ser Ala Trp Gln Gln Val Ile Ala Asp              20 25 30 Ser Ser Glu Asp His Ile Thr Ala Thr His Leu Arg Glu Leu Leu Ser          35 40 45 Arg Ser Arg Ala Lys Thr Ala Pro Phe Ala Arg Gln Ile Thr Ala Ile      50 55 60 Val Pro Gly Ser Leu Ala Arg Leu Glu Glu Leu Thr Arg Glu Asp Ala  65 70 75 80 Gln Ile Gly Ala Asp Ile Asp Ala Gln Pro Ala Val Ser Ile Pro Gly                  85 90 95 Ile Leu Leu Gly Gln Ile Ala Ala Thr Arg Gln Leu Arg Asp Leu Gly             100 105 110 Leu Asp Val Ala Ala Ala Ser Arg Leu Gly His Ser Gln Gly Ile Leu         115 120 125 Gly Val Glu Ala Val Asp Asn Glu Glu Asp Val Leu Ala Phe Ala Ile     130 135 140 Leu Leu Gly Ala Ala Ala Ser Gln Phe Ala Gly Lys Gly Ala His Met 145 150 155 160 Leu Ser Val Arg Gly Leu Ser Arg Glu Ile Ile Gln Asp Thr Ile Ala                 165 170 175 Gly Val Asp Gly Val Glu Val Ser Leu Arg Asn Ala Arg Ala His Phe             180 185 190 Val Val Ser Gly Lys Pro Glu Ala Leu Lys Lys Ala Ala Ala Ala Leu         195 200 205 Gln Arg Ala Ala Asp Val Tyr Asn Glu Asp Ile Asn Glu Lys Arg Lys     210 215 220 Gly Gly Ser Leu Ala Glu Pro Lys Phe Asp Tyr Leu Asp Val Ala Ile 225 230 235 240 Pro Phe His His Ser Ser Met Gln Asp Ala Ala Asp Leu Ala Val Glu                 245 250 255 Trp Ala Thr Thr Cys Gly Leu Asn Val Asn Ala Arg Ala Leu Ala Glu             260 265 270 Ala Ile Leu Val Asn Pro Ala Asp Trp Val Glu Gln Ile Ala Asn Leu         275 280 285 Lys Ala Asp Tyr Val Leu Ser Leu Asp Ala Gly Val Ser Arg Phe Thr     290 295 300 Ala Pro Leu Leu Asp Gly Arg Gly Ile Ser Leu Val Pro Ala Phe Ser 305 310 315 320 Ala Ala Glu Arg Asp Asn Leu Ala Arg Pro Gly Phe His Val Pro Thr                 325 330 335 Ala Glu Asp Trp Ser Glu Phe Ala Pro Lys Leu Val Lys Leu Pro Asn             340 345 350 Gly Glu His Lys Val Leu Thr Gly Phe Ser Arg Leu Thr Gly Tyr Ser         355 360 365 Pro Ile Val Leu Ala Gly Met Thr Pro Thr Thr Val Asp Pro Glu Ile     370 375 380 Val Ala Ala Ala Ala Asn Ala Gly His Trp Ala Glu Met Ala Gly Gly 385 390 395 400 Gly Gln Tyr Ser Glu Glu Val Phe Thr Lys Asn Lys Glu Lys Leu Val                 405 410 415 Ser Leu Leu Lys Val Gly Arg Ser Ala Gln Phe Asn Ser Met Phe Phe             420 425 430 Asp Arg Tyr Met Trp Asn Leu Gln Phe Gly Ala Gln Arg Ile Val Ser         435 440 445 Lys Ala Arg Ala Thr Gly Thr Ser Ile Asn Gly Val Val Val Ser Ala     450 455 460 Gly Ile Pro Glu Val Glu Glu Ala Thr Glu Leu Ile Asn Asp Leu Asn 465 470 475 480 Ala Asp Gly Phe Pro Tyr Val Ala Phe Lys Pro Gly Thr Val Asp Gln                 485 490 495 Ile Arg Ala Thr Leu Lys Ile Ala Asp Ala Asn Pro Glu Thr Lys Ile             500 505 510 Ile Ile Gln Ile Glu Asp Gly His Ala Gly Gly His His Ser Trp Val         515 520 525 Asn Leu Asp Asp Leu Leu Leu Thr Thr Tyr Ala Glu Leu Arg Ser Arg     530 535 540 Lys Asn Val Val Val Met Ile Gly Gly Gly Ile Gly Thr Pro Ala Lys 545 550 555 560 Ala Ala Tyr Tyr Leu Thr Gly Glu Trp Ser Thr Asp Leu Gly Phe Pro                 565 570 575 Ala Met Pro Val Asp Gly Ile Leu Val Gly Thr Ala Ala Met Ala Thr             580 585 590 Lys Glu Ala Thr Thr Ser Pro Gln Val Lys Gln Ala Leu Val Asp Thr         595 600 605 Pro Gly Val Asp Pro His Asp Ala Gly Gly Trp Val Gly Arg Gly Asp     610 615 620 Ala Arg Gly Gly Val Thr Ser Gly Leu Ser His Leu His Ala Asp Met 625 630 635 640 Tyr Glu Leu Asp Asn Asp Ser Ala Ala Ala Ser Arg Leu Ile Ser Ser                 645 650 655 Ile Asp Ser Asp Asp Tyr Ala Asp His Arg Glu Glu Leu Ile Glu Ala             660 665 670 Ile Asn Lys Thr Ala Lys Pro Phe Phe Gly Glu Val Glu Glu Met Thr         675 680 685 Tyr Ala Glu Trp Ile Gln Arg Trp Val Glu Leu Ala Tyr Pro Thr Gln     690 695 700 Asp Pro Thr Trp Asp Asp Arg Phe Leu Asp Leu Val His Arg Ile Glu 705 710 715 720 Ala Arg Leu Asn Glu Ala Glu His Gly Ala Ile Thr Thr Leu Phe Pro                 725 730 735 Asp His Ala Ser Val Glu Asn Glu Glu Glu Ala Val Glu Lys Leu Leu             740 745 750 Ala Ala Tyr Pro Gln Ala Arg Glu Ile Gln Val Ser Ala Arg Asp Ala         755 760 765 Ala Trp Phe Ile Gly Leu Cys Arg Lys His His Lys Pro Met Pro Trp     770 775 780 Val Pro Ala Ile Asp Ala Asp Leu Ala Arg Trp Trp Gly Leu Asp Thr 785 790 795 800 Leu Trp Gln Ser Gln Asn Glu Arg Tyr Gly Ala Asn Ser Val Arg Val                 805 810 815 Ile Pro Gly Pro Val Ser Val Ala Gly Ile Asp Arg Val Asp Glu Pro             820 825 830 Val Ala Glu Leu Leu Gly Arg Phe Glu Ala Ala Cys Val Asp Ala Leu         835 840 845 Asp Gly Glu Pro Glu Glu Ile Phe Ala Arg Leu Asn Glu Ser Lys Asn     850 855 860 Glu Arg Glu Phe Leu Leu Ala Thr Pro His Ile Val Trp His Gly Asn 865 870 875 880 Leu Ile Asp Asn Pro Ala His Val Leu Asn Glu Gly Ala Phe Glu Leu                 885 890 895 Ile Glu Glu Asp Gly Tyr Trp Val Ile Arg Ile Leu Ala Asp Ser Tyr             900 905 910 Phe Asp Asp Leu Pro Val Glu Gln Arg Pro Tyr Leu Val Gln His Val         915 920 925 Asp Ile Pro Val Glu Leu Gly Asp Ala Gly     930 935 <210> 173 <211> 921 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (898) <223> RXN01090 <400> 173 gccggtttgg gctggttgga gctctagatc gtaagtggtg tcgtacccat gacgtaccat 60 taaccacgaa cgttttaaag aagccacgaa ggagcctgac atg gcg tta cca cta 115                                             Met Ala Leu Pro Leu                                               1 5 ccc agc aag agc gct cga gca ctt gtt act ggg gca agc caa ggc att 163 Pro Ser Lys Ser Ala Arg Ala Leu Val Thr Gly Ala Ser Gln Gly Ile                  10 15 20 ggc ctc gcc atc gcc aaa gat ttg gcg cgg tat ggg cac aac ctc att 211 Gly Leu Ala Ile Ala Lys Asp Leu Ala Arg Tyr Gly His Asn Leu Ile              25 30 35 ttg gtt gct cgc cgc gag gat gtc ctc aaa gag atc gcc gca gat cta 259 Leu Val Ala Arg Arg Glu Asp Val Leu Lys Glu Ile Ala Ala Asp Leu          40 45 50 gag aag aag cac ggc gtg atc gtt gag gtc cgc ccg gtg gat ttg agt 307 Glu Lys Lys His Gly Val Ile Val Glu Val Arg Pro Val Asp Leu Ser      55 60 65 gat gag cca gcc cgc aag gtg ttg atc gat gag atc aag aca agg gaa 355 Asp Glu Pro Ala Arg Lys Val Leu Ile Asp Glu Ile Lys Thr Arg Glu  70 75 80 85 atc aac atc atc att aac tct gct ggc atc gca agc ttt ggg ccg ttc 403 Ile Asn Ile Ile Ile Asn Ser Ala Gly Ile Ala Ser Phe Gly Pro Phe                  90 95 100 aag gac cag gat tgg tct tat gag act gcc cag ttc tca ctt aat gcc 451 Lys Asp Gln Asp Trp Ser Tyr Glu Thr Ala Gln Phe Ser Leu Asn Ala             105 110 115 aca gcc gtt ttt gag ctc acc cac gcg gtg ttg ggt ggc atg att gac 499 Thr Ala Val Phe Glu Leu Thr His Ala Val Leu Gly Met Ile Asp         120 125 130 cgt ggc acg ggc gct att tgc aat gtg gga tct gcg gct ggc aat gtg 547 Arg Gly Thr Gly Ala Ile Cys Asn Val Gly Ser Ala Ala Gly Asn Val     135 140 145 cca atc ccc aac aac gcc acg tat gtg ctc acc aag gct ggc gtg aac 595 Pro Ile Pro Asn Asn Ala Thr Tyr Val Leu Thr Lys Ala Gly Val Asn 150 155 160 165 gcg ttc acc gag gca atg cat tat gag ctg cgc gga act ggt gtg gcg 643 Ala Phe Thr Glu Ala Met His Tyr Glu Leu Arg Gly Thr Gly Val Ala                 170 175 180 tgt act ttg ctc gca ccg gga cct gtc cgt gag gcg gag atc cct gag 691 Cys Thr Leu Leu Ala Pro Gly Pro Val Arg Glu Ala Glu Ile Pro Glu             185 190 195 tct gag aag tcg atc gtg gac aag gtt gtc cct gat ttc ttg tgg acc 739 Ser Glu Lys Ser Ile Val Asp Lys Val Val Pro Asp Phe Leu Trp Thr         200 205 210 acc tat gag tcc tgc tcc gca gag acc ttg cgt gcg ctg tct aag aat 787 Thr Tyr Glu Ser Cys Ser Ala Glu Thr Leu Arg Ala Leu Ser Lys Asn     215 220 225 cag cgt cgc gtt gtt cca ggt ccg ctg tcc aag gcc atg aat ttt gtg 835 Gln Arg Arg Val Val Pro Gly Pro Leu Ser Lys Ala Met Asn Phe Val 230 235 240 245 tcc tct gtt gct cca acc gct gtg ctc tcc cct gtt atg ggc tgg gtt 883 Ser Ser Val Ala Pro Thr Ala Val Leu Ser Pro Val Met Gly Trp Val                 250 255 260 tat aag aag atg ggt tagtttttaa aagtgtctga atc 921 Tyr Lys Lys Met Gly             265 <210> 174 <211> 266 <212> PRT <213> Corynebacterium glutamicum <400> 174 Met Ala Leu Pro Leu Pro Ser Lys Ser Ala Arg Ala Leu Val Thr Gly   1 5 10 15 Ala Ser Gln Gly Ile Gly Leu Ala Ile Ala Lys Asp Leu Ala Arg Tyr              20 25 30 Gly His Asn Leu Ile Leu Val Ala Arg Arg Glu Asp Val Leu Lys Glu          35 40 45 Ile Ala Ala Asp Leu Glu Lys Lys His Gly Val Ile Val Glu Val Arg      50 55 60 Pro Val Asp Leu Ser Asp Glu Pro Ala Arg Lys Val Leu Ile Asp Glu  65 70 75 80 Ile Lys Thr Arg Glu Ile Asn Ile Ile Ile Asn Ser Ala Gly Ile Ala                  85 90 95 Ser Phe Gly Pro Phe Lys Asp Gln Asp Trp Ser Tyr Glu Thr Ala Gln             100 105 110 Phe Ser Leu Asn Ala Thr Ala Val Phe Glu Leu Thr His Ala Val Leu         115 120 125 Gly Gly Met Ile Asp Arg Gly Thr Gly Ala Ile Cys Asn Val Gly Ser     130 135 140 Ala Ala Gly Asn Val Pro Ile Pro Asn Asn Ala Thr Tyr Val Leu Thr 145 150 155 160 Lys Ala Gly Val Asn Ala Phe Thr Glu Ala Met His Tyr Glu Leu Arg                 165 170 175 Gly Thr Gly Val Ala Cys Thr Leu Leu Ala Pro Gly Pro Val Arg Glu             180 185 190 Ala Glu Ile Pro Glu Ser Glu Lys Ser Ile Val Asp Lys Val Val Pro         195 200 205 Asp Phe Leu Trp Thr Thr Tyr Glu Ser Cys Ser Ala Glu Thr Leu Arg     210 215 220 Ala Leu Ser Lys Asn Gln Arg Arg Val Val Pro Gly Pro Leu Ser Lys 225 230 235 240 Ala Met Asn Phe Val Ser Ser Val Ala Pro Thr Ala Val Leu Ser Pro                 245 250 255 Val Met Gly Trp Val Tyr Lys Lys Met Gly             260 265 <175> 175 <211> 1293 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1270) <223> RXN02062 <400> 175 ttgtctaaac atcgttttgg ggtccgaatg atagcccctt ttaatgcccc catttcggta 60 tcgctgcgca actgttttta gatggctaat ctttgaaatt atg aga gtc gga atg 115                                             Met Arg Val Gly Met                                               1 5 atg aca aga gag tat cca cca gag gtt tac ggc ggc gct ggc gtg cac 163 Met Thr Arg Glu Tyr Pro Pro Glu Val Tyr Gly Gly Ala Gly Val His                  10 15 20 gtc acc gaa ttg acc cga ttc atg cgt gag atc gct gaa gtt gat gtt 211 Val Thr Glu Leu Thr Arg Phe Met Arg Glu Ile Ala Glu Val Asp Val              25 30 35 cac tgc atg ggt gca cct cgc gat atg gag gga gtt ttc gtc cac ggc 259 His Cys Met Gly Ala Pro Arg Asp Met Glu Gly Val Phe Val His Gly          40 45 50 gtc gat cct gcc ttg gaa agc gcg aac cct gcg att aag aca ctg tcc 307 Val Asp Pro Ala Leu Glu Ser Ala Asn Pro Ala Ile Lys Thr Leu Ser      55 60 65 acc ggt tta cgc atg gca gaa gct gca aac aac gtg gat gtc gtg cac 355 Thr Gly Leu Arg Met Ala Glu Ala Ala Asn Asn Val Asp Val Val His  70 75 80 85 tca cac act tgg tat gca ggt ctt ggc ggc cac ctt gca gct cgt ctc 403 Ser His Thr Trp Tyr Ala Gly Leu Gly Gly His Leu Ala Ala Arg Leu                  90 95 100 cac ggc att cct cac gtg gct acc gcg cac tct ttg gag cca gat cgc 451 His Gly Ile Pro His Val Ala Thr Ala His Ser Leu Glu Pro Asp Arg             105 110 115 cca tgg aag cgt gag cag ctt ggc ggt gga tac gac gtg tcc tcc tgg 499 Pro Trp Lys Arg Glu Gln Leu Gly Gly Gly Tyr Asp Val Ser Ser Trp         120 125 130 tct gaa aaa aat gcc atg gaa tac gct gac gcg gtc atc gct gtg tcg 547 Ser Glu Lys Asn Ala Met Glu Tyr Ala Asp Ala Val Ile Ala Val Ser     135 140 145 gct cgc atg aaa gat tcc atc ctc gct gcg tac cct cgc atc gag ccg 595 Ala Arg Met Lys Asp Ser Ile Leu Ala Ala Tyr Pro Arg Ile Glu Pro 150 155 160 165 gac aac gtg cgt gtt gtc ctc aac ggc atc gac act gag ttg tgg cag 643 Asp Asn Val Arg Val Val Leu Asn Gly Ile Asp Thr Glu Leu Trp Gln                 170 175 180 cct cgc ccg act ttc gat gac gcg gaa gat tcc gta ctc cgc tcc cta 691 Pro Arg Pro Thr Phe Asp Asp Ala Glu Asp Ser Val Leu Arg Ser Leu             185 190 195 ggc gtt gac cca cag cgg ccc atc gtc gca ttt gtc ggc cgc atc acc 739 Gly Val Asp Pro Gln Arg Pro Ile Val Ala Phe Val Gly Arg Ile Thr         200 205 210 cgc caa aaa ggc gtc gag cac ctc atc aag gca gca gcg ctt ttc gac 787 Arg Gln Lys Gly Val Glu His Leu Ile Lys Ala Ala Ala Leu Phe Asp     215 220 225 gag tcc gtg cag ctt gtg ctc tgt gcc ggc gcg cca gac acc ccc gaa 835 Glu Ser Val Gln Leu Val Leu Cys Ala Gly Ala Pro Asp Thr Pro Glu 230 235 240 245 atc gca gct cgc acc acc gcc ctg gtg gaa gaa ctc cag gca aag cgc 883 Ile Ala Ala Arg Thr Thr Ala Leu Val Glu Glu Leu Gln Ala Lys Arg                 250 255 260 gaa ggc att ttc tgg gtt cag gac atg ctg ggc aag gac aaa atc caa 931 Glu Gly Ile Phe Trp Val Gln Asp Met Leu Gly Lys Asp Lys Ile Gln             265 270 275 gag att ctc acc gct gct gac acc ttc gtg tgc cca tcc att tac gag 979 Glu Ile Leu Thr Ala Ala Asp Thr Phe Val Cys Pro Ser Ile Tyr Glu         280 285 290 cca ctg ggc atc gtg aac ttg gaa gca atg gcc tgc aac acc gca gtt 1027 Pro Leu Gly Ile Val Asn Leu Glu Ala Met Ala Cys Asn Thr Ala Val     295 300 305 gtc gca tcc gac gtt gga ggc atc cct gag gtt gtt gtc gac ggc acc 1075 Val Ala Ser Asp Val Gly Gly Ile Pro Glu Val Val Val Asp Gly Thr 310 315 320 325 acc ggc gcc ctc gtt cac tac gac gaa aat gat gtc gaa acc ttc gag 1123 Thr Gly Ala Leu Val His Tyr Asp Glu Asn Asp Val Glu Thr Phe Glu                 330 335 340 cgc gat atc gcc gaa gcg gtg aat aaa atg gtc gct gat cga gag acc 1171 Arg Asp Ile Ala Glu Ala Val Asn Lys Met Val Ala Asp Arg Glu Thr             345 350 355 gca gcc aaa ttt ggt ctc gca ggg cgc gaa cgt gct atc aat gat ttc 1219 Ala Ala Lys Phe Gly Leu Ala Gly Arg Glu Arg Ala Ile Asn Asp Phe         360 365 370 tcc tgg gca acg att gct cag cag acc att gat gtg tac aaa tcc ttg 1267 Ser Trp Ala Thr Ile Ala Gln Gln Thr Ile Asp Val Tyr Lys Ser Leu     375 380 385 atg taaaaccgaa agccggggaa cct 1293 Met 390 <210> 176 <211> 390 <212> PRT <213> Corynebacterium glutamicum <400> 176 Met Arg Val Gly Met Met Thr Arg Glu Tyr Pro Pro Glu Val Tyr Gly   1 5 10 15 Gly Ala Gly Val His Val Thr Glu Leu Thr Arg Phe Met Arg Glu Ile              20 25 30 Ala Glu Val Asp Val His Cys Met Gly Ala Pro Arg Asp Met Glu Gly          35 40 45 Val Phe Val His Gly Val Asp Pro Ala Leu Glu Ser Ala Asn Pro Ala      50 55 60 Ile Lys Thr Leu Ser Thr Gly Leu Arg Met Ala Glu Ala Ala Asn Asn  65 70 75 80 Val Asp Val Val His Ser His Thr Trp Tyr Ala Gly Leu Gly Gly His                  85 90 95 Leu Ala Ala Arg Leu His Gly Ile Pro His Val Ala Thr Ala His Ser             100 105 110 Leu Glu Pro Asp Arg Pro Trp Lys Arg Glu Gln Leu Gly Gly Gly Tyr         115 120 125 Asp Val Ser Ser Trp Ser Glu Lys Asn Ala Met Glu Tyr Ala Asp Ala     130 135 140 Val Ile Ala Val Ser Ala Arg Met Lys Asp Ser Ile Leu Ala Ala Tyr 145 150 155 160 Pro Arg Ile Glu Pro Asp Asn Val Arg Val Val Leu Asn Gly Ile Asp                 165 170 175 Thr Glu Leu Trp Gln Pro Arg Pro Thr Phe Asp Asp Ala Glu Asp Ser             180 185 190 Val Leu Arg Ser Leu Gly Val Asp Pro Gln Arg Pro Ile Val Ala Phe         195 200 205 Val Gly Arg Ile Thr Arg Gln Lys Gly Val Glu His Leu Ile Lys Ala     210 215 220 Ala Ala Leu Phe Asp Glu Ser Val Gln Leu Val Leu Cys Ala Gly Ala 225 230 235 240 Pro Asp Thr Pro Glu Ile Ala Ala Arg Thr Thr Ala Leu Val Glu Glu                 245 250 255 Leu Gln Ala Lys Arg Glu Gly Ile Phe Trp Val Gln Asp Met Leu Gly             260 265 270 Lys Asp Lys Ile Gln Glu Ile Leu Thr Ala Ala Asp Thr Phe Val Cys         275 280 285 Pro Ser Ile Tyr Glu Pro Leu Gly Ile Val Asn Leu Glu Ala Met Ala     290 295 300 Cys Asn Thr Ala Val Val Ala Ser Asp Val Gly Gly Ile Pro Glu Val 305 310 315 320 Val Val Asp Gly Thr Thr Gly Ala Leu Val His Tyr Asp Glu Asn Asp                 325 330 335 Val Glu Thr Phe Glu Arg Asp Ile Ala Glu Ala Val Asn Lys Met Val             340 345 350 Ala Asp Arg Glu Thr Ala Ala Lys Phe Gly Leu Ala Gly Arg Glu Arg         355 360 365 Ala Ile Asn Asp Phe Ser Trp Ala Thr Ile Ala Gln Gln Thr Ile Asp     370 375 380 Val Tyr Lys Ser Leu Met 385 390 <210> 177 <211> 1266 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (1243) <223> RXN02148 <400> 177 gcctcagact acggaatccc tgtgcaggtg gtatctgttg attcagcacc gttttatggt 60 gcgcgtcgct actaagaaat agttcgtcag gagaatcttt gtg tct gca tcc cga 115                                             Val Ser Ala Ser Arg                                               1 5 aaa act ctc gtt gtg acc aat gat ttt cct cca cgg atc ggc gga atc 163 Lys Thr Leu Val Val Thr Asn Asp Phe Pro Pro Arg Ile Gly Gly Ile                  10 15 20 caa agc tat ttg agg gat ttc atc gct act caa gat cct gag tcg atc 211 Gln Ser Tyr Leu Arg Asp Phe Ile Ala Thr Gln Asp Pro Glu Ser Ile              25 30 35 gtg gtg ttt gcg tcg act caa aac gct gag gaa gcg cat gcc tac gac 259 Val Val Phe Ala Ser Thr Gln Asn Ala Glu Glu Ala His Ala Tyr Asp          40 45 50 aag act ttg gac tat gag gtc att agg tgg cct cgt tcg gtg atg ctg 307 Lys Thr Leu Asp Tyr Glu Val Ile Arg Trp Pro Arg Ser Val Met Leu      55 60 65 ccc acc cca aca acg gca cac gct atg gcg gag atc att cgt gag cga 355 Pro Thr Pro Thr Thr Ala His Ala Met Ala Glu Ile Ile Arg Glu Arg  70 75 80 85 gag atc gat aat gtg tgg ttc ggt gct gcg gct ccg ttg gcg ttg atg 403 Glu Ile Asp Asn Val Trp Phe Gly Ala Ala Ala Pro Leu Ala Leu Met                  90 95 100 gca ggc aca gcg aag cag gca ggt gcg agc aag gtt att gcc tcc act 451 Ala Gly Thr Ala Lys Gln Ala Gly Ala Ser Lys Val Ile Ala Ser Thr             105 110 115 cat ggg cat gag gtg ggg tgg tca atg ctt cct gga tcg aga caa tcg 499 His Gly His Glu Val Gly Trp Ser Met Leu Pro Gly Ser Arg Gln Ser         120 125 130 ttg cgc aaa atc ggc act gag gtg gac gtg ctg act tat atc tcg cag 547 Leu Arg Lys Ile Gly Thr Glu Val Asp Val Leu Thr Tyr Ile Ser Gln     135 140 145 tac acg ctg cgc aga ttc aaa agt gct ttt gga tcg cac ccg act ttt 595 Tyr Thr Leu Arg Arg Phe Lys Ser Ala Phe Gly Ser His Pro Thr Phe 150 155 160 165 gaa cat ttg cct tcc ggc gtg gac gtt aag aga ttc act ccg gcc acg 643 Glu His Leu Pro Ser Gly Val Asp Val Lys Arg Phe Thr Pro Ala Thr                 170 175 180 cca gag gac aaa agc gca aca agg aaa aag cta gga ttc acg gac acc 691 Pro Glu Asp Lys Ser Ala Thr Arg Lys Lys Leu Gly Phe Thr Asp Thr             185 190 195 acc ccg gtt att gcc tgt aac tcg cgt tta gtg ccg agg aaa ggc cag 739 Thr Pro Val Ile Ala Cys Asn Ser Arg Leu Val Pro Arg Lys Gly Gln         200 205 210 gac tcg ctg atc aag gcg atg cca cag gtg att gcg gcg cgc cca gat 787 Asp Ser Leu Ile Lys Ala Met Pro Gln Val Ile Ala Ala Arg Pro Asp     215 220 225 gcg cag ttg ctc att gtg ggc agt ggg cga tac gag tcg act ttg cgg 835 Ala Gln Leu Leu Ile Val Gly Ser Gly Arg Tyr Glu Ser Thr Leu Arg 230 235 240 245 cgc ctt gcc act gac gtg agc cag aac gtg aaa ttc ctt ggg cgc ctt 883 Arg Leu Ala Thr Asp Val Ser Gln Asn Val Lys Phe Leu Gly Arg Leu                 250 255 260 gaa tat caa gat atg atc aac acg ctt gcc gcc gca gat att ttc gcg 931 Glu Tyr Gln Asp Met Ile Asn Thr Leu Ala Ala Ala Asp Ile Phe Ala             265 270 275 atg cca gcg cgc acc cgc ggt ggc gga ctt gat gtt gaa ggc ttg ggc 979 Met Pro Ala Arg Thr Arg Gly Gly Gly Leu Asp Val Glu Gly Leu Gly         280 285 290 att gtc tat ctc gag gca caa gcc tgc gga gtg ccg gtg ata gcc ggc 1027 Ile Val Tyr Leu Glu Ala Gln Ala Cys Gly Val Pro Val Ile Ala Gly     295 300 305 acc tct ggc ggc gcg cca gag acg gtg act ccg gca act ggc ctg gtt 1075 Thr Ser Gly Gly Ala Pro Glu Thr Val Thr Pro Ala Thr Gly Leu Val 310 315 320 325 gtg gag ggg tcg gac gtc gat aag ctg tct gag ctt tta att gag ctt 1123 Val Glu Gly Ser Asp Val Asp Lys Leu Ser Glu Leu Leu Ile Glu Leu                 330 335 340 ctc gac gat ccg atc cgc cgc gcc gcg atg ggc gct gca ggt agg gcg 1171 Leu Asp Asp Pro Ile Arg Arg Ala Ala Met Gly Ala Ala Gly Arg Ala             345 350 355 cat gtg gag gcc gaa tgg tcg tgg gaa atc atg ggg gag cgg ttg acc 1219 His Val Glu Ala Glu Trp Ser Trp Glu Ile Met Gly Glu Arg Leu Thr         360 365 370 aat att ttg cag agt gaa cca cga tgatggttgg acagctgttg ata 1266 Asn Ile Leu Gln Ser Glu Pro Arg     375 380 <210> 178 <211> 381 <212> PRT <213> Corynebacterium glutamicum <400> 178 Val Ser Ala Ser Arg Lys Thr Leu Val Val Thr Asn Asp Phe Pro Pro   1 5 10 15 Arg Ile Gly Gly Ile Gln Ser Tyr Leu Arg Asp Phe Ile Ala Thr Gln              20 25 30 Asp Pro Glu Ser Ile Val Val Phe Ala Ser Thr Gln Asn Ala Glu Glu          35 40 45 Ala His Ala Tyr Asp Lys Thr Leu Asp Tyr Glu Val Ile Arg Trp Pro      50 55 60 Arg Ser Val Met Leu Pro Thr Pro Thr Thr Ala His Ala Met Ala Glu  65 70 75 80 Ile Ile Arg Glu Arg Glu Ile Asp Asn Val Trp Phe Gly Ala Ala Ala                  85 90 95 Pro Leu Ala Leu Met Ala Gly Thr Ala Lys Gln Ala Gly Ala Ser Lys             100 105 110 Val Ile Ala Ser Thr His Gly His Glu Val Gly Trp Ser Met Leu Pro         115 120 125 Gly Ser Arg Gln Ser Leu Arg Lys Ile Gly Thr Glu Val Asp Val Leu     130 135 140 Thr Tyr Ile Ser Gln Tyr Thr Leu Arg Arg Phe Lys Ser Ala Phe Gly 145 150 155 160 Ser His Pro Thr Phe Glu His Leu Pro Ser Gly Val Asp Val Lys Arg                 165 170 175 Phe Thr Pro Ala Thr Pro Glu Asp Lys Ser Ala Thr Arg Lys Lys Leu             180 185 190 Gly Phe Thr Asp Thr Thr Pro Val Ile Ala Cys Asn Ser Arg Leu Val         195 200 205 Pro Arg Lys Gly Gln Asp Ser Leu Ile Lys Ala Met Pro Gln Val Ile     210 215 220 Ala Ala Arg Pro Asp Ala Gln Leu Leu Ile Val Gly Ser Gly Arg Tyr 225 230 235 240 Glu Ser Thr Leu Arg Arg Leu Ala Thr Asp Val Ser Gln Asn Val Lys                 245 250 255 Phe Leu Gly Arg Leu Glu Tyr Gln Asp Met Ile Asn Thr Leu Ala Ala             260 265 270 Ala Asp Ile Phe Ala Met Pro Ala Arg Thr Arg Gly Gly Gly Leu Asp         275 280 285 Val Glu Gly Leu Gly Ile Val Tyr Leu Glu Ala Gln Ala Cys Gly Val     290 295 300 Pro Val Ile Ala Gly Thr Ser Gly Gly Ala Pro Glu Thr Val Thr Pro 305 310 315 320 Ala Thr Gly Leu Val Val Glu Gly Ser Asp Val Asp Lys Leu Ser Glu                 325 330 335 Leu Leu Ile Glu Leu Leu Asp Asp Pro Ile Arg Arg Ala Ala Met Gly             340 345 350 Ala Ala Gly Arg Ala His Val Glu Ala Glu Trp Ser Trp Glu Ile Met         355 360 365 Gly Glu Arg Leu Thr Asn Ile Leu Gln Ser Glu Pro Arg     370 375 380 <210> 179 <211> 1287 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1264) <223> RXN02595 <400> 179 gtgggtaaag gggactccga ggaagtccac gtcgtcttct ttcgcggcgc tgaggatggt 60 ttcgcggatt tgtgcggggg agtgggtggg agagaaaacg gtg atc gtt gtg gcc 115                                             Val Ile Val Val Ala                                               1 5 atg gct tcc att atg gct tgt tta aaa gca gct aga ctg aat aac cct 163 Met Ala Ser Ile Met Ala Cys Leu Lys Ala Ala Arg Leu Asn Asn Pro                  10 15 20 atg aag atc ctt ttg ttg tgc tgg cgt gat acc act cat cct caa ggt 211 Met Lys Ile Leu Leu Leu Cys Trp Arg Asp Thr Thr His Pro Gln Gly              25 30 35 ggc gga agt gaa cgc tat ctg gag cgg gtg ggt gag ttt ttg gcg gat 259 Gly Gly Ser Glu Arg Tyr Leu Glu Arg Val Gly Glu Phe Leu Ala Asp          40 45 50 cag ggc cat gag gtg gtg ttt cgt act gct ggg cac acg gat gcg cca 307 Gln Gly His Glu Val Val Phe Arg Thr Ala Gly His Thr Asp Ala Pro      55 60 65 cgg cgt tct ttc cgc gat ggt gtg agg tat tcc agg agc ggt ggg aag 355 Arg Arg Ser Phe Arg Asp Gly Val Arg Tyr Ser Arg Ser Gly Gly Lys  70 75 80 85 ttt agt gtg tat ccc aag gcg tgg gtg gcc atg atg ttg ggt cgt gtg 403 Phe Ser Val Tyr Pro Lys Ala Trp Val Ala Met Met Leu Gly Arg Val                  90 95 100 ggg att ggc acg ttt tcc aag gtt gat gtg gtg gtg gat acg cag aat 451 Gly Ile Gly Thr Phe Ser Lys Val Asp Val Val Val Asp Thr Gln Asn             105 110 115 ggc att ccg ttt ttt gga aag ttt ttc tcc ggt aag ccg act gtg ttg 499 Gly Ile Pro Phe Phe Gly Lys Phe Phe Ser Gly Lys Pro Thr Val Leu         120 125 130 ctc acg cat cat tgc cat aag gag cag tgg ccg gtg gtg ggt cgg gtg 547 Leu Thr His His Cys His Lys Glu Gln Trp Pro Val Val Gly Arg Val     135 140 145 ctg gcg aag gtt ggt tgg ctg att gag agc cag atc gcg ccg cgc gct 595 Leu Ala Lys Val Gly Trp Leu Ile Glu Ser Gln Ile Ala Pro Arg Ala 150 155 160 165 tac aaa act gcg ccg tat gtg act gtt tca gag ccg agc gct gag gag 643 Tyr Lys Thr Ala Pro Tyr Val Thr Val Ser Glu Pro Ser Ala Glu Glu                 170 175 180 ctc att gcg ttg ggt gtg gat cag cag cgg att cat atc gtg cgc aat 691 Leu Ile Ala Leu Gly Val Asp Gln Gln Arg Ile His Ile Val Arg Asn             185 190 195 ggc gtg gat ccc gtg ccg ctg cac acg ccg aag ctg gat cgc gat ggc 739 Gly Val Asp Pro Val Pro Leu His Thr Pro Lys Leu Asp Arg Asp Gly         200 205 210 cag cat gcg gtg acg ttg tcg cgc ctg gtt ccg cac aag cag att gag 787 Gln His Ala Val Thr Leu Ser Arg Leu Val Pro His Lys Gln Ile Glu     215 220 225 cat gcg atg gat gtc gtc gcg gcg ctc gac ggc gtg gtg ctg gat gta 835 His Ala Met Asp Val Val Ala Ala Leu Asp Gly Val Val Leu Asp Val 230 235 240 245 gtc gaa agc ggt tgg tgg cag aag gaa ctg gtc gat tat gcc cgc acg 883 Val Glu Ser Gly Trp Trp Gln Lys Glu Leu Val Asp Tyr Ala Arg Thr                 250 255 260 ctg ggt gtg agc gat cgc gtg gtt ttc cac ggc cag gtc gcc gag gat 931 Leu Gly Val Ser Asp Arg Val Val Phe His Gly Gln Val Ala Glu Asp             265 270 275 cac aag cac gcc ctg ttg gag cgc gcc acg att cat ctc atg cct tcg 979 His Lys His Ala Leu Leu Glu Arg Ala Thr Ile His Leu Met Pro Ser         280 285 290 cgc aag gaa ggc tgg ggc ctg gcg gtc acg gag gcg gcg cag cac ggc 1027 Arg Lys Glu Gly Trp Gly Leu Ala Val Thr Glu Ala Ala Gln His Gly     295 300 305 gtt ccg acg atc ggt tac cga agc tca ggc ggc ctg cgc gat tcc gtc 1075 Val Pro Thr Ile Gly Tyr Arg Ser Ser Gly Gly Leu Arg Asp Ser Val 310 315 320 325 gtc gac ggc gaa acc ggc ctg ctt gtc gac tcc aag gcc gag ctt att 1123 Val Asp Gly Glu Thr Gly Leu Leu Val Asp Ser Lys Ala Glu Leu Ile                 330 335 340 tca gcc acc aaa acc ctg ctt atc gac gcc tcc ctc cgc tcc aag ctc 1171 Ser Ala Thr Lys Thr Leu Leu Ile Asp Ala Ser Leu Arg Ser Lys Leu             345 350 355 ggc gcc agc gcg aag cag cgc gcc gaa aac tac aag tgg gac acc gcg 1219 Gly Ala Ser Ala Lys Gln Arg Ala Glu Asn Tyr Lys Trp Asp Thr Ala         360 365 370 gga gcg cag ttc gag gaa cta ctt ctt ggt ctt gcg tcg aaa aag 1264 Gly Ala Gln Phe Glu Glu Leu Leu Leu Gly Leu Ala Ser Lys Lys     375 380 385 tagtcccagc ggcaacgcca tcc 1287 <210> 180 <211> 388 <212> PRT <213> Corynebacterium glutamicum <400> 180 Val Ile Val Val Ala Met Ala Ser Ile Met Ala Cys Leu Lys Ala Ala   1 5 10 15 Arg Leu Asn Asn Pro Met Lys Ile Leu Leu Leu Cys Trp Arg Asp Thr              20 25 30 Thr His Pro Gln Gly Gly Gly Ser Glu Arg Tyr Leu Glu Arg Val Gly          35 40 45 Glu Phe Leu Ala Asp Gln Gly His Glu Val Val Phe Arg Thr Ala Gly      50 55 60 His Thr Asp Ala Pro Arg Arg Ser Phe Arg Asp Gly Val Arg Tyr Ser  65 70 75 80 Arg Ser Gly Gly Lys Phe Ser Val Tyr Pro Lys Ala Trp Val Ala Met                  85 90 95 Met Leu Gly Arg Val Gly Ile Gly Thr Phe Ser Lys Val Asp Val Val             100 105 110 Val Asp Thr Gln Asn Gly Ile Pro Phe Phe Gly Lys Phe Phe Ser Gly         115 120 125 Lys Pro Thr Val Leu Leu Thr His His Cys His Lys Glu Gln Trp Pro     130 135 140 Val Val Gly Arg Val Leu Ala Lys Val Gly Trp Leu Ile Glu Ser Gln 145 150 155 160 Ile Ala Pro Arg Ala Tyr Lys Thr Ala Pro Tyr Val Thr Val Ser Glu                 165 170 175 Pro Ser Ala Glu Glu Leu Ile Ala Leu Gly Val Asp Gln Gln Arg Ile             180 185 190 His Ile Val Arg Asn Gly Val Asp Pro Val Pro Leu His Thr Pro Lys         195 200 205 Leu Asp Arg Asp Gly Gln His Ala Val Thr Leu Ser Arg Leu Val Pro     210 215 220 His Lys Gln Ile Glu His Ala Met Asp Val Val Ala Ala Leu Asp Gly 225 230 235 240 Val Val Leu Asp Val Val Glu Ser Gly Trp Trp Gln Lys Glu Leu Val                 245 250 255 Asp Tyr Ala Arg Thr Leu Gly Val Ser Asp Arg Val Val Phe His Gly             260 265 270 Gln Val Ala Glu Asp His Lys His Ala Leu Leu Glu Arg Ala Thr Ile         275 280 285 His Leu Met Pro Ser Arg Lys Glu Gly Trp Gly Leu Ala Val Thr Glu     290 295 300 Ala Ala Gln His Gly Val Pro Thr Ile Gly Tyr Arg Ser Ser Gly Gly 305 310 315 320 Leu Arg Asp Ser Val Val Asp Gly Glu Thr Gly Leu Leu Val Asp Ser                 325 330 335 Lys Ala Glu Leu Ile Ser Ala Thr Lys Thr Leu Leu Ile Asp Ala Ser             340 345 350 Leu Arg Ser Lys Leu Gly Ala Ser Ala Lys Gln Arg Ala Glu Asn Tyr         355 360 365 Lys Trp Asp Thr Ala Gly Ala Gln Phe Glu Glu Leu Leu Leu Gly Leu     370 375 380 Ala Ser Lys Lys 385 <210> 181 <211> 2334 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (2311) <223> RXS00148 <400> 181 ctttgagggc agcgcgcatg cgcccgatgg ttatttgaac atgacaattg atgccgcggc 60 gacgctggct gacctgctag atgctttggg agcttaaatc atg acg tcg atc cct 115                                             Met Thr Ser Ile Pro                                               1 5 aat ttt tca gac atc cca ttg act gct gag aca cgt gca tcg gag tca 163 Asn Phe Ser Asp Ile Pro Leu Thr Ala Glu Thr Arg Ala Ser Glu Ser                  10 15 20 cac aac gtt gac gcc ggc aag gtg tgg aac act ccc gaa ggc att gat 211 His Asn Val Asp Ala Gly Lys Val Trp Asn Thr Pro Glu Gly Ile Asp              25 30 35 gtc aag cgc gta ttc acg cag gct gac cgc gac gag gcg caa gcg gcg 259 Val Lys Arg Val Phe Thr Gln Ala Asp Arg Asp Glu Ala Gln Ala Ala          40 45 50 gga cat ccg gtg gat tct ttg cca ggt caa aag cca ttt atg cgc ggg 307 Gly His Pro Val Asp Ser Leu Pro Gly Gln Lys Pro Phe Met Arg Gly      55 60 65 ccg tac cca act atg tac acc aat cag ccg tgg acg att cgc cag tac 355 Pro Tyr Pro Thr Met Tyr Thr Asn Gln Pro Trp Thr Ile Arg Gln Tyr  70 75 80 85 gca ggc ttt tca acc gcc gcg gaa tcc aat gcg ttt tat cgg agg aac 403 Ala Gly Phe Ser Thr Ala Ala Glu Ser Asn Ala Phe Tyr Arg Arg Asn                  90 95 100 ctt gct gcg ggt caa aaa ggt ttg tcg gtt gcg ttc gat cta gcg acc 451 Leu Ala Ala Gly Gln Lys Gly Leu Ser Val Ala Phe Asp Leu Ala Thr             105 110 115 cac cgc ggt tat gac tcg gat aat gag cgc gtg gtc ggc gat gtg ggt 499 His Arg Gly Tyr Asp Ser Asp Asn Glu Arg Val Val Gly Asp Val Gly         120 125 130 atg gcc ggc gtg gcg att gat tcg att ttg gat atg cgt cag ctg ttt 547 Met Ala Gly Val Ala Ile Asp Ser Ile Leu Asp Met Arg Gln Leu Phe     135 140 145 gat ggc att gat ttg tcc agc gtg tcg gtg tcg atg acc atg aat ggc 595 Asp Gly Ile Asp Leu Ser Ser Val Ser Val Ser Met Thr Met Asn Gly 150 155 160 165 gct gtg ctg ccg att ctt gcg ttc tat atc gtg gcg gct gag gaa caa 643 Ala Val Leu Pro Ile Leu Ala Phe Tyr Ile Val Ala Ala Glu Glu Gln                 170 175 180 ggt gtg ggt ccg gag cag ctt gcg ggc acg atc cag aat gac atc ttg 691 Gly Val Gly Pro Glu Gln Leu Ala Gly Thr Ile Gln Asn Asp Ile Leu             185 190 195 aaa gaa ttt atg gtg cgc aac acc tat att tat ccg ccg aag ccg tcg 739 Lys Glu Phe Met Val Arg Asn Thr Tyr Ile Tyr Pro Pro Lys Pro Ser         200 205 210 atg cgc atc att tcc aac atc ttt gag tac acc tcc ttg aag atg cca 787 Met Arg Ile Ile Ser Asn Ile Phe Glu Tyr Thr Ser Leu Lys Met Pro     215 220 225 cgt ttt aac tcc att tcg att tct ggc tat cac atc cag gaa gcg gga 835 Arg Phe Asn Ser Ile Ser Ile Ser Gly Tyr His Ile Gln Glu Ala Gly 230 235 240 245 gcg act gcc gat ttg gag ctg gcc tac act ctg gcg gat ggt att gaa 883 Ala Thr Ala Asp Leu Glu Leu Ala Tyr Thr Leu Ala Asp Gly Ile Glu                 250 255 260 tac atc cgt gca ggt aaa gag gta ggc ctt gac gtg gat aag ttc gcg 931 Tyr Ile Arg Ala Gly Lys Glu Val Gly Leu Asp Val Asp Lys Phe Ala             265 270 275 cct cgt ctg tcc ttc ttc tgg ggt att tct atg tac acc ttc atg gag 979 Pro Arg Leu Ser Phe Phe Trp Gly Ile Ser Met Tyr Thr Phe Met Glu         280 285 290 atc gca aag ctg cgt gcg gga cga ctg ctg tgg agc gag ttg gtg gca 1027 Ile Ala Lys Leu Arg Ala Gly Arg Leu Leu Trp Ser Glu Leu Val Ala     295 300 305 aaa ttc gat ccg aaa aac gcc aag tcc cag tcg ctg cgc acg cac tcg 1075 Lys Phe Asp Pro Lys Asn Ala Lys Ser Gln Ser Leu Arg Thr His Ser 310 315 320 325 cag acc tct ggt tgg tcg ttg acc gcg cag gat gtg tac aac aac gtc 1123 Gln Thr Ser Gly Trp Ser Leu Thr Ala Gln Asp Val Tyr Asn Asn Val                 330 335 340 gcc cgc acc gcg att gag gcg atg gct gca acc cag ggc cac acc cag 1171 Ala Arg Thr Ala Ile Glu Ala Met Ala Ala Thr Gln Gly His Thr Gln             345 350 355 tcg ctg cac acc aat gca ctt gat gag gcg ttg gcg ctg ccc acc gat 1219 Ser Leu His Thr Asn Ala Leu Asp Glu Ala Leu Ala Leu Pro Thr Asp         360 365 370 ttc tct gct cgt atc gcc cga aac acc cag ctg ttg ctg cag cag gaa 1267 Phe Ser Ala Arg Ile Ala Arg Asn Thr Gln Leu Leu Leu Gln Gln Glu     375 380 385 tct ggc acg gtg cgt cca gtt gat cca tgg gcg ggc tcc tat tac gtg 1315 Ser Gly Thr Val Arg Pro Val Asp Pro Trp Ala Gly Ser Tyr Tyr Val 390 395 400 405 gag tgg ttg acc aat gag ctg gct aac cgc gcg cgc aag cac atc gat 1363 Glu Trp Leu Thr Asn Glu Leu Ala Asn Arg Ala Arg Lys His Ile Asp                 410 415 420 gag gtg gag gaa gcc ggc gga atg gcg cag gcc acc gcg cag gga att 1411 Glu Val Glu Glu Ala Gly Gly Met Ala Gln Ala Thr Ala Gln Gly Ile             425 430 435 cct aag ctg cgc att gag gaa tca gcg gca cgc acc cag gct cgc att 1459 Pro Lys Leu Arg Ile Glu Glu Ser Ala Ala Arg Thr Gln Ala Arg Ile         440 445 450 gat tcc ggc cgc cag gcg ctg atc ggc gtg aat cgc tac gtg gcg gaa 1507 Asp Ser Gly Arg Gln Ala Leu Ile Gly Val Asn Arg Tyr Val Ala Glu     455 460 465 gaa gat gag gaa att gaa gtc ctc aag gtt gac aac acc aag gtt cgc 1555 Glu Asp Glu Glu Ile Glu Val Leu Lys Val Asp Asn Thr Lys Val Arg 470 475 480 485 gca gaa cag ttg gct aaa ctc gcg caa ctg aaa gca gag cgc aac gat 1603 Ala Glu Gln Leu Ala Lys Leu Ala Gln Leu Lys Ala Glu Arg Asn Asp                 490 495 500 gcg gaa gtc aag gct gcg ctg gat gcg ttg aca gct gct gcc cgc aac 1651 Ala Glu Val Lys Ala Ala Leu Asp Ala Leu Thr Ala Ala Ala Arg Asn             505 510 515 gag cat aaa gag cca ggg gat ttg gat cag aac ctg ctc aaa ctt gcc 1699 Glu His Lys Glu Pro Gly Asp Leu Asp Gln Asn Leu Leu Lys Leu Ala         520 525 530 gtc gat gct gcg cgc gca aaa gct acc att gga gag atc tcc gat gct 1747 Val Asp Ala Ala Arg Ala Lys Ala Thr Ile Gly Glu Ile Ser Asp Ala     535 540 545 ttg gaa gtt gtc ttt ggc cgc cac gaa gca gaa atc agg acg ctg tct 1795 Leu Glu Val Val Phe Gly Arg His Glu Ala Glu Ile Arg Thr Leu Ser 550 555 560 565 ggc gtg tac aag gat gag gtt gga aag gaa ggc aca gtg agc aac gtc 1843 Gly Val Tyr Lys Asp Glu Val Gly Lys Glu Gly Thr Val Ser Asn Val                 570 575 580 gaa cgc gcg atc gcc ctg gct gac gcc ttt gag gct gag gaa ggc cgc 1891 Glu Arg Ala Ile Ala Leu Ala Asp Ala Phe Glu Ala Glu Glu Gly Arg             585 590 595 cgc cca cgt atc ttt att gcc aag atg ggc cag gat gga cat gac cgt 1939 Arg Pro Arg Ile Phe Ile Ala Lys Met Gly Gln Asp Gly His Asp Arg         600 605 610 gga cag aag gtt gtc gcg tct gcc tat gct gac ctg ggc atg gac gtg 1987 Gly Gln Lys Val Val Ala Ser Ala Tyr Ala Asp Leu Gly Met Asp Val     615 620 625 gat gtt gga ccg ctg ttt caa act cca gcc gaa gct gcc cgc gcc gcc 2035 Asp Val Gly Pro Leu Phe Gln Thr Pro Ala Glu Ala Ala Arg Ala Ala 630 635 640 645 gtg gac gcc gat gtt cac gtg gtg ggt atg tct tcg ctg gca gca ggc 2083 Val Asp Ala Asp Val His Val Val Gly Met Ser Ser Leu Ala Ala Gly                 650 655 660 cac ctc acc ttg ctg ccc gag ctg aag aaa gaa ctt gca gct ctt ggc 2131 His Leu Thr Leu Leu Pro Glu Leu Lys Lys Glu Leu Ala Ala Leu Gly             665 670 675 cgc gat gac att ctg gtc acc gtg ggc ggc gtc att ccg ccg ggc gat 2179 Arg Asp Asp Ile Leu Val Thr Val Gly Gly Val Ile Pro Pro Gly Asp         680 685 690 ttc cag gat ctc tac gat atg ggt gcc gcc gcg att tac cct tca gga 2227 Phe Gln Asp Leu Tyr Asp Met Gly Ala Ala Ala Ile Tyr Pro Ser Gly     695 700 705 acc gtc atc gcg gag tcg gcg atc gat ctg atc acc cga ctc gcc gca 2275 Thr Val Ile Ala Glu Ser Ala Ile Asp Leu Ile Thr Arg Leu Ala Ala 710 715 720 725 cac ctg ggc ttt gac ctg gat gtg gat gtg aat gaa tgatcacggt 2321 His Leu Gly Phe Asp Leu Asp Val Asp Val Asn Glu                 730 735 ttcctagaag aca 2334 <210> 182 <211> 737 <212> PRT <213> Corynebacterium glutamicum <400> 182 Met Thr Ser Ile Pro Asn Phe Ser Asp Ile Pro Leu Thr Ala Glu Thr   1 5 10 15 Arg Ala Ser Glu Ser His Asn Val Asp Ala Gly Lys Val Trp Asn Thr              20 25 30 Pro Glu Gly Ile Asp Val Lys Arg Val Phe Thr Gln Ala Asp Arg Asp          35 40 45 Glu Ala Gln Ala Ala Gly His Pro Val Asp Ser Leu Pro Gly Gln Lys      50 55 60 Pro Phe Met Arg Gly Pro Tyr Pro Thr Met Tyr Thr Asn Gln Pro Trp  65 70 75 80 Thr Ile Arg Gln Tyr Ala Gly Phe Ser Thr Ala Ala Glu Ser Asn Ala                  85 90 95 Phe Tyr Arg Arg Asn Leu Ala Ala Gly Gln Lys Gly Leu Ser Val Ala             100 105 110 Phe Asp Leu Ala Thr His Arg Gly Tyr Asp Ser Asp Asn Glu Arg Val         115 120 125 Val Gly Asp Val Gly Met Ala Gly Val Ala Ile Asp Ser Ile Leu Asp     130 135 140 Met Arg Gln Leu Phe Asp Gly Ile Asp Leu Ser Ser Val Ser Val Ser 145 150 155 160 Met Thr Met Asn Gly Ala Val Leu Pro Ile Leu Ala Phe Tyr Ile Val                 165 170 175 Ala Ala Glu Glu Gln Gly Val Gly Pro Glu Gln Leu Ala Gly Thr Ile             180 185 190 Gln Asn Asp Ile Leu Lys Glu Phe Met Val Arg Asn Thr Tyr Ile Tyr         195 200 205 Pro Pro Lys Pro Ser Met Arg Ile Ile Ser Asn Ile Phe Glu Tyr Thr     210 215 220 Ser Leu Lys Met Pro Arg Phe Asn Ser Ile Ser Ile Ser Gly Tyr His 225 230 235 240 Ile Gln Glu Ala Gly Ala Thr Ala Asp Leu Glu Leu Ala Tyr Thr Leu                 245 250 255 Ala Asp Gly Ile Glu Tyr Ile Arg Ala Gly Lys Glu Val Gly Leu Asp             260 265 270 Val Asp Lys Phe Ala Pro Arg Leu Ser Phe Phe Trp Gly Ile Ser Met         275 280 285 Tyr Thr Phe Met Glu Ile Ala Lys Leu Arg Ala Gly Arg Leu Leu Trp     290 295 300 Ser Glu Leu Val Ala Lys Phe Asp Pro Lys Asn Ala Lys Ser Gln Ser 305 310 315 320 Leu Arg Thr His Ser Gln Thr Ser Gly Trp Ser Leu Thr Ala Gln Asp                 325 330 335 Val Tyr Asn Asn Val Ala Arg Thr Ala Ile Glu Ala Met Ala Ala Thr             340 345 350 Gln Gly His Thr Gln Ser Leu His Thr Asn Ala Leu Asp Glu Ala Leu         355 360 365 Ala Leu Pro Thr Asp Phe Ser Ala Arg Ile Ala Arg Asn Thr Gln Leu     370 375 380 Leu Leu Gln Gln Glu Ser Gly Thr Val Arg Pro Val Asp Pro Trp Ala 385 390 395 400 Gly Ser Tyr Tyr Val Glu Trp Leu Thr Asn Glu Leu Ala Asn Arg Ala                 405 410 415 Arg Lys His Ile Asp Glu Val Glu Glu Ala Gly Gly Met Ala Gln Ala             420 425 430 Thr Ala Gln Gly Ile Pro Lys Leu Arg Ile Glu Glu Ser Ala Ala Arg         435 440 445 Thr Gln Ala Arg Ile Asp Ser Gly Arg Gln Ala Leu Ile Gly Val Asn     450 455 460 Arg Tyr Val Ala Glu Glu Asp Glu Glu Ile Glu Val Leu Lys Val Asp 465 470 475 480 Asn Thr Lys Val Arg Ala Glu Gln Leu Ala Lys Leu Ala Gln Leu Lys                 485 490 495 Ala Glu Arg Asn Asp Ala Glu Val Lys Ala Ala Leu Asp Ala Leu Thr             500 505 510 Ala Ala Ala Arg Asn Glu His Lys Glu Pro Gly Asp Leu Asp Gln Asn         515 520 525 Leu Leu Lys Leu Ala Val Asp Ala Ala Arg Ala Lys Ala Thr Ile Gly     530 535 540 Glu Ile Ser Asp Ala Leu Glu Val Val Phe Gly Arg His Glu Ala Glu 545 550 555 560 Ile Arg Thr Leu Ser Gly Val Tyr Lys Asp Glu Val Gly Lys Glu Gly                 565 570 575 Thr Val Ser Asn Val Glu Arg Ala Ile Ala Leu Ala Asp Ala Phe Glu             580 585 590 Ala Glu Glu Gly Arg Arg Pro Arg Ile Phe Ile Ala Lys Met Gly Gln         595 600 605 Asp Gly His Asp Arg Gly Gln Lys Val Val Ala Ser Ala Tyr Ala Asp     610 615 620 Leu Gly Met Asp Val Asp Val Gly Pro Leu Phe Gln Thr Pro Ala Glu 625 630 635 640 Ala Ala Arg Ala Ala Val Asp Ala Asp Val His Val Val Gly Met Ser                 645 650 655 Ser Leu Ala Ala Gly His Leu Thr Leu Leu Pro Glu Leu Lys Lys Glu             660 665 670 Leu Ala Ala Leu Gly Arg Asp Asp Ile Leu Val Thr Val Gly Gly Val         675 680 685 Ile Pro Pro Gly Asp Phe Gln Asp Leu Tyr Asp Met Gly Ala Ala Ala     690 695 700 Ile Tyr Pro Ser Gly Thr Val Ile Ala Glu Ser Ala Ile Asp Leu Ile 705 710 715 720 Thr Arg Leu Ala Ala His Leu Gly Phe Asp Leu Asp Val Asp Val Asn                 725 730 735 Glu <210> 183 <211> 1971 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1948) <223> RXS00149 <400> 183 ttttcgtagg taaacacagg tgaaggcttt acaagcttgt gaactcccta cacaaaagca 60 atccaatagc tatccataag caagagaaag taagtctacg ttg act gat ctc aca 115                                             Leu Thr Asp Leu Thr                                               1 5 aag act gcg gtg ccc gag gaa ctt tca gag aac ctc gaa act tgg tac 163 Lys Thr Ala Val Pro Glu Glu Leu Ser Glu Asn Leu Glu Thr Trp Tyr                  10 15 20 aag gct gtg gcc ggt gtt ttc gcg cgc aca cag aaa aaa gac atc ggc 211 Lys Ala Val Ala Gly Val Phe Ala Arg Thr Gln Lys Lys Asp Ile Gly              25 30 35 gac att gcc gta gat gtg tgg aag aaa ctc atc gtc act aca ccg gat 259 Asp Ile Ala Val Asp Val Trp Lys Lys Leu Ile Val Thr Thr Pro Asp          40 45 50 ggt gtt gat atc aat ccg ctg tac acc aga gca gat gag tcc cag agg 307 Gly Val Asp Ile Asn Pro Leu Tyr Thr Arg Ala Asp Glu Ser Gln Arg      55 60 65 aaa ttc act gag gtt cct ggt gag ttt ccc ttc act agg gga acc act 355 Lys Phe Thr Glu Val Pro Gly Glu Phe Pro Phe Thr Arg Gly Thr Thr  70 75 80 85 gtt gat ggt gaa cgc gtt ggt tgg ggt gtt act gag act ttc gga cat 403 Val Asp Gly Glu Arg Val Gly Trp Gly Val Thr Glu Thr Phe Gly His                  90 95 100 gac agc ccg aag aat atc aac gct gcg gtg ctg aat gct ctg aat tct 451 Asp Ser Pro Lys Asn Ile Asn Ala Ala Val Leu Asn Ala Leu Asn Ser             105 110 115 ggc acc acc aca ttg ggt ttt gag ttc tct gag gaa ttc acg gca gct 499 Gly Thr Thr Thr Leu Gly Phe Glu Phe Ser Glu Glu Phe Thr Ala Ala         120 125 130 gat ctt aaa gtt gct ctc gaa ggc gtg tat ctc aac atg gct ccg ttg 547 Asp Leu Lys Val Ala Leu Glu Gly Val Tyr Leu Asn Met Ala Pro Leu     135 140 145 ctg att cat gcg ggt gga tcc acg tca gag gtt gca gcg gcg ttg tat 595 Leu Ile His Ala Gly Gly Ser Thr Ser Glu Val Ala Ala Ala Leu Tyr 150 155 160 165 acg ttg gcg gag gaa gcc gga acg ttt ttt gct gcg ttg acc ttg ggt 643 Thr Leu Ala Glu Glu Ala Gly Thr Phe Phe Ala Ala Leu Thr Leu Gly                 170 175 180 tct cgt cct ttg acg gcg cag gtt gat ggt tcg cac agt gac acc att 691 Ser Arg Pro Leu Thr Ala Gln Val Asp Gly Ser His Ser Asp Thr Ile             185 190 195 gaa gaa gca gtt cag ttg gca gtg aat gct tcc aag cgt gcg aat gtg 739 Glu Glu Ala Val Gln Leu Ala Val Asn Ala Ser Lys Arg Ala Asn Val         200 205 210 cgc gct atc ttg gtg gat ggt tcc agt ttt tcc aac cag ggc gcg tcg 787 Arg Ala Ile Leu Val Asp Gly Ser Ser Phe Ser Asn Gln Gly Ala Ser     215 220 225 gat gct caa gaa att ggt cta agt atc gcc gcc ggt gtg gat tat gtc 835 Asp Ala Gln Glu Ile Gly Leu Ser Ile Ala Ala Gly Val Asp Tyr Val 230 235 240 245 cgt cgc ttg gtc gat gca ggc ctt tcc acg gaa gct gca ctt aag cag 883 Arg Arg Leu Val Asp Ala Gly Leu Ser Thr Glu Ala Ala Leu Lys Gln                 250 255 260 gtg gcg ttc cgt ttt gcg gtc acc gat gag cag ttc gcg cag att tct 931 Val Ala Phe Arg Phe Ala Val Thr Asp Glu Gln Phe Ala Gln Ile Ser             265 270 275 aag ctg cgt gtg gct cga cgt ctg tgg gcc agg gtg tgt gag gtg ctt 979 Lys Leu Arg Val Ala Arg Arg Leu Trp Ala Arg Val Cys Glu Val Leu         280 285 290 ggt ttt cca gag ctg gcc gta gca cca cag cat gcg gtg act gca cga 1027 Gly Phe Pro Glu Leu Ala Val Ala Pro Gln His Ala Val Thr Ala Arg     295 300 305 gcg atg ttt agc cag cgt gat ccg tgg gtg aat atg ctg cgc agt act 1075 Ala Met Phe Ser Gln Arg Asp Pro Trp Val Asn Met Leu Arg Ser Thr 310 315 320 325 gtt gca gct ttc gct gca ggc gtc ggt gga gca acc gat gtg gag gtt 1123 Val Ala Ala Phe Ala Ala Gly Val Gly Gly Ala Thr Asp Val Glu Val                 330 335 340 cgt act ttt gat gat gcg atc cca gat gga gtt cct gga gtg tcg agg 1171 Arg Thr Phe Asp Asp Ala Ile Pro Asp Gly Val Pro Gly Val Ser Arg             345 350 355 aat ttc gct cac cgc atc gcg cgc aat act aat ttg ttg ttg cta gaa 1219 Asn Phe Ala His Arg Ile Ala Arg Asn Thr Asn Leu Leu Leu Leu Glu         360 365 370 gag tca cat ctt ggt cac gtg gtt gat cct gct ggt gga tca tat ttc 1267 Glu Ser His Leu Gly His Val Val Asp Pro Ala Gly Gly Ser Tyr Phe     375 380 385 gtg gag agc ttc acc gat gat cta gcg gag aag gcg tgg gct gtg ttc 1315 Val Glu Ser Phe Thr Asp Asp Leu Ala Glu Lys Ala Trp Ala Val Phe 390 395 400 405 agt ggc atc gaa gct gag ggc gga tac agt gca gct tgt gca tcc ggc 1363 Ser Gly Ile Glu Ala Glu Gly Gly Tyr Ser Ala Ala Cys Ala Ser Gly                 410 415 420 acg gtg act gcc atg ctt gat cag acg tgg gag cag act cgc gct gat 1411 Thr Val Thr Ala Met Leu Asp Gln Thr Trp Glu Gln Thr Arg Ala Asp             425 430 435 gtg gcg tcg aga aag aag aag ctc act gga att aat gag ttc ccg aac 1459 Val Ala Ser Arg Lys Lys Lys Leu Thr Gly Ile Asn Glu Phe Pro Asn         440 445 450 ttg gcg gag tct ccg ctg cca gct gat cgt cgg gta gaa cct gca ggt 1507 Leu Ala Glu Ser Pro Leu Pro Ala Asp Arg Arg Val Glu Pro Ala Gly     455 460 465 gtg cgt cga tgg gca gcg gat ttt gaa gcg ctg cgc aat cgt tcg gat 1555 Val Arg Arg Trp Ala Ala Asp Phe Glu Ala Leu Arg Asn Arg Ser Asp 470 475 480 485 gct ttc ttg gaa aag aac ggc gcg agg cca cag atc acg atg att cct 1603 Ala Phe Leu Glu Lys Asn Gly Ala Arg Pro Gln Ile Thr Met Ile Pro                 490 495 500 ctg gga ccg ttg tcc aag cac aat att cgc act ggt ttt act tcc aac 1651 Leu Gly Pro Leu Ser Lys His Asn Ile Arg Thr Gly Phe Thr Ser Asn             505 510 515 ctg ttg gct tcc ggt ggc att gaa gca atc aac ccg ggt caa ctt gtt 1699 Leu Leu Ala Ser Gly Gly Ile Glu Ala Ile Asn Pro Gly Gln Leu Val         520 525 530 ccc ggc act gac gct ttt gca gaa gct gca cag gcc gca ggc att gta 1747 Pro Gly Thr Asp Ala Phe Ala Glu Ala Ala Gln Ala Ala Gly Ile Val     535 540 545 gtg gtg tgt gga acg gac caa gag tat gcc gaa acg ggg gag gga gcc 1795 Val Val Cys Gly Thr Asp Gln Glu Tyr Ala Glu Thr Gly Glu Gly Ala 550 555 560 565 gtc gaa aag ctc cgc gaa gcg ggc gtt gag cgc atc ctg ctt gct ggc 1843 Val Glu Lys Leu Arg Glu Ala Gly Val Glu Arg Ile Leu Leu Ala Gly                 570 575 580 gcg ccg aag agc ttt gag ggc agc gcg cat gcg ccc gat ggt tat ttg 1891 Ala Pro Lys Ser Phe Glu Gly Ser Ala His Ala Pro Asp Gly Tyr Leu             585 590 595 aac atg aca att gat gcc gcg gcg acg ctg gct gac ctg cta gat gct 1939 Asn Met Thr Ile Asp Ala Ala Ala Thr Leu Ala Asp Leu Leu Asp Ala         600 605 610 ttg gga gct taaatcatga cgtcgatccc taa 1971 Leu Gly Ala     615 <210> 184 <211> 616 <212> PRT <213> Corynebacterium glutamicum <400> 184 Leu Thr Asp Leu Thr Lys Thr Ala Val Pro Glu Glu Leu Ser Glu Asn   1 5 10 15 Leu Glu Thr Trp Tyr Lys Ala Val Ala Gly Val Phe Ala Arg Thr Gln              20 25 30 Lys Lys Asp Ile Gly Asp Ile Ala Val Asp Val Trp Lys Lys Leu Ile          35 40 45 Val Thr Thr Pro Asp Gly Val Asp Ile Asn Pro Leu Tyr Thr Arg Ala      50 55 60 Asp Glu Ser Gln Arg Lys Phe Thr Glu Val Pro Gly Glu Phe Pro Phe  65 70 75 80 Thr Arg Gly Thr Thr Val Asp Gly Glu Arg Val Gly Trp Gly Val Thr                  85 90 95 Glu Thr Phe Gly His Asp Ser Pro Lys Asn Ile Asn Ala Ala Val Leu             100 105 110 Asn Ala Leu Asn Ser Gly Thr Thr Thr Leu Gly Phe Glu Phe Ser Glu         115 120 125 Glu Phe Thr Ala Ala Asp Leu Lys Val Ala Leu Glu Gly Val Tyr Leu     130 135 140 Asn Met Ala Pro Leu Leu Ile His Ala Gly Gly Ser Thr Ser Glu Val 145 150 155 160 Ala Ala Ala Leu Tyr Thr Leu Ala Glu Glu Ala Gly Thr Phe Phe Ala                 165 170 175 Ala Leu Thr Leu Gly Ser Arg Pro Leu Thr Ala Gln Val Asp Gly Ser             180 185 190 His Ser Asp Thr Ile Glu Glu Ala Val Gln Leu Ala Val Asn Ala Ser         195 200 205 Lys Arg Ala Asn Val Arg Ala Ile Leu Val Asp Gly Ser Ser Phe Ser     210 215 220 Asn Gln Gly Ala Ser Asp Ala Gln Glu Ile Gly Leu Ser Ile Ala Ala 225 230 235 240 Gly Val Asp Tyr Val Arg Arg Leu Val Asp Ala Gly Leu Ser Thr Glu                 245 250 255 Ala Ala Leu Lys Gln Val Ala Phe Arg Phe Ala Val Thr Asp Glu Gln             260 265 270 Phe Ala Gln Ile Ser Lys Leu Arg Val Ala Arg Arg Leu Trp Ala Arg         275 280 285 Val Cys Glu Val Leu Gly Phe Pro Glu Leu Ala Val Ala Pro Gln His     290 295 300 Ala Val Thr Ala Arg Ala Met Phe Ser Gln Arg Asp Pro Trp Val Asn 305 310 315 320 Met Leu Arg Ser Thr Val Ala Ala Phe Ala Ala Gly Val Gly Gly Ala                 325 330 335 Thr Asp Val Glu Val Arg Thr Phe Asp Asp Ala Ile Pro Asp Gly Val             340 345 350 Pro Gly Val Ser Arg Asn Phe Ala His Arg Ile Ala Arg Asn Thr Asn         355 360 365 Leu Leu Leu Leu Glu Glu Ser His Leu Gly His Val Val Asp Pro Ala     370 375 380 Gly Gly Ser Tyr Phe Val Glu Ser Phe Thr Asp Asp Leu Ala Glu Lys 385 390 395 400 Ala Trp Ala Val Phe Ser Gly Ile Glu Ala Glu Gly Gly Tyr Ser Ala                 405 410 415 Ala Cys Ala Ser Gly Thr Val Thr Ala Met Leu Asp Gln Thr Trp Glu             420 425 430 Gln Thr Arg Ala Asp Val Ala Ser Arg Lys Lys Lys Leu Thr Gly Ile         435 440 445 Asn Glu Phe Pro Asn Leu Ala Glu Ser Pro Leu Pro Ala Asp Arg Arg     450 455 460 Val Glu Pro Ala Gly Val Arg Arg Trp Ala Ala Asp Phe Glu Ala Leu 465 470 475 480 Arg Asn Arg Ser Asp Ala Phe Leu Glu Lys Asn Gly Ala Arg Pro Gln                 485 490 495 Ile Thr Met Ile Pro Leu Gly Pro Leu Ser Lys His Asn Ile Arg Thr             500 505 510 Gly Phe Thr Ser Asn Leu Leu Ala Ser Gly Gly Ile Glu Ala Ile Asn         515 520 525 Pro Gly Gln Leu Val Pro Gly Thr Asp Ala Phe Ala Glu Ala Ala Gln     530 535 540 Ala Ala Gly Ile Val Val Val Cys Gly Thr Asp Gln Glu Tyr Ala Glu 545 550 555 560 Thr Gly Glu Gly Ala Val Glu Lys Leu Arg Glu Ala Gly Val Glu Arg                 565 570 575 Ile Leu Leu Ala Gly Ala Pro Lys Ser Phe Glu Gly Ser Ala His Ala             580 585 590 Pro Asp Gly Tyr Leu Asn Met Thr Ile Asp Ala Ala Thr Leu Ala         595 600 605 Asp Leu Leu Asp Ala Leu Gly Ala     610 615 <210> 185 <211> 1179 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1156) <223> RXS02106 <400> 185 ggtcgccgct tttcgacgcc cgcctgcggc gggatgactg tgatggaggg gcgcgtcgac 60 aagcaaaatc tctttagcaa attcggttac tgtggggcgc atg aat aac cat ttt 115                                             Met Asn Asn His Phe                                               1 5 gag ctc aaa gta cct ggt gga aag ctt gtc gtc gtt gat gtg acc acc 163 Glu Leu Lys Val Pro Gly Gly Lys Leu Val Val Val Asp Val Thr Thr                  10 15 20 gat ctg gat tcc att gct gac gtg aag att tcc ggc gat ttc ttc ctc 211 Asp Leu Asp Ser Ile Ala Asp Val Lys Ile Ser Gly Asp Phe Phe Leu              25 30 35 gaa ccc gat gag gca ttc ttc gcc ctt ggc cgg gcg ctg cag ggg gcg 259 Glu Pro Asp Glu Ala Phe Phe Ala Leu Gly Arg Ala Leu Gln Gly Ala          40 45 50 tcg gtg ggt gat aac act gat cgt ttg cag gca aag ttg gat gca gcg 307 Ser Val Gly Asp Asn Thr Asp Arg Leu Gln Ala Lys Leu Asp Ala Ala      55 60 65 ttg gcg gaa tat gat gac gtt gag cta cac ggc ttt agc act gcg gat 355 Leu Ala Glu Tyr Asp Asp Val Glu Leu His Gly Phe Ser Thr Ala Asp  70 75 80 85 att gct tta gct gtg cgt cgg gca gtc acc ggc gcg caa gat ttc acc 403 Ile Ala Leu Ala Val Arg Arg Ala Val Thr Gly Ala Gln Asp Phe Thr                  90 95 100 gat tat gaa tgg gaa atc ctg cac cca ggg gtg ctt cct acc cca ctt 451 Asp Tyr Glu Trp Glu Ile Leu His Pro Gly Val Leu Pro Thr Pro Leu             105 110 115 aac gtt gcg ttg gat gag ctc ctt ttg gac caa gtt gcc agt ggt cag 499 Asn Val Ala Leu Asp Glu Leu Leu Leu Asp Gln Val Ala Ser Gly Gln         120 125 130 cgt ggc ccg acg atg cgc att tgg gat tgg gat gat cgc gcc aca gtg 547 Arg Gly Pro Thr Met Arg Ile Trp Asp Trp Asp Asp Arg Ala Thr Val     135 140 145 atc ggt agt ttc cag tca tat gtc aat gaa atc aac caa gaa ggc gtt 595 Ile Gly Ser Phe Gln Ser Tyr Val Asn Glu Ile Asn Gln Glu Gly Val 150 155 160 165 aat gaa cat ggt gtg acc gtg gta cga cgc atg tct ggt ggc ggt gca 643 Asn Glu His Gly Val Thr Val Val Arg Arg Met Ser Gly Gly Gly Ala                 170 175 180 atg ttt atg gag ggc ggc aac tgc atc acc tat tcc ctg tat gca ccg 691 Met Phe Met Glu Gly Gly Asn Cys Ile Thr Tyr Ser Leu Tyr Ala Pro             185 190 195 gaa tct ctc gtt gct ggt ttg agc tat gag cag tcc tat gaa tat ttg 739 Glu Ser Leu Val Ala Gly Leu Ser Tyr Glu Gln Ser Tyr Glu Tyr Leu         200 205 210 gat cgt tgg gtg att gct gcg ctg aag aca cac gat gtt gac gct tgg 787 Asp Arg Trp Val Ile Ala Ala Leu Lys Thr His Asp Val Asp Ala Trp     215 220 225 tac gtg cct atc aat gac atc acc tcc acc ggc gga aaa atc ggt ggc 835 Tyr Val Pro Ile Asn Asp Ile Thr Ser Thr Gly Gly Lys Ile Gly Gly 230 235 240 245 gct gca cag aaa cgt cgc agt ggc gca gtc ctc cac cac gtg acc atg 883 Ala Ala Gln Lys Arg Arg Ser Gly Ala Val Leu His His Val Thr Met                 250 255 260 tcc tat gac atc gat gcg gac atg atg acc cag gtg ttg cgc att gga 931 Ser Tyr Asp Ile Asp Ala Asp Met Met Thr Gln Val Leu Arg Ile Gly             265 270 275 aag gtg aag att tcc gac aag ggt ctt cgc agc gca aag aag cgc gtt 979 Lys Val Lys Ile Ser Asp Lys Gly Leu Arg Ser Ala Lys Lys Arg Val         280 285 290 gat cct ctg cgc cgc caa aca ggt gca tca cgt gag caa atc atc gac 1027 Asp Pro Leu Arg Arg Gln Thr Gly Ala Ser Arg Glu Gln Ile Isp     295 300 305 acc cta aag tcc aca ttc agt gct agg tac ggc gcg caa gaa gta gag 1075 Thr Leu Lys Ser Thr Phe Ser Ala Arg Tyr Gly Ala Gln Glu Val Glu 310 315 320 325 ctc agc gat gaa gat ttc gcg gca ggc cac gac cta gta aaa acc aaa 1123 Leu Ser Asp Glu Asp Phe Ala Ala Gly His Asp Leu Val Lys Thr Lys                 330 335 340 tac gcc acc gag gag tgg act aag cga gtt caa tagtttctat ggatctgcac 1176 Tyr Ala Thr Glu Glu Trp Thr Lys Arg Val Gln             345 350 aag 1179 <210> 186 <211> 352 <212> PRT <213> Corynebacterium glutamicum <400> 186 Met Asn Asn His Phe Glu Leu Lys Val Pro Gly Gly Lys Leu Val Val   1 5 10 15 Val Asp Val Thr Thr Asp Leu Asp Ser Ile Ala Asp Val Lys Ile Ser              20 25 30 Gly Asp Phe Phe Leu Glu Pro Asp Glu Ala Phe Phe Ala Leu Gly Arg          35 40 45 Ala Leu Gln Gly Ala Ser Val Gly Asp Asn Thr Asp Arg Leu Gln Ala      50 55 60 Lys Leu Asp Ala Ala Leu Ala Glu Tyr Asp Asp Val Glu Leu His Gly  65 70 75 80 Phe Ser Thr Ala Asp Ile Ala Leu Ala Val Arg Arg Ala Val Thr Gly                  85 90 95 Ala Gln Asp Phe Thr Asp Tyr Glu Trp Glu Ile Leu His Pro Gly Val             100 105 110 Leu Pro Thr Pro Leu Asn Val Ala Leu Asp Glu Leu Leu Leu Asp Gln         115 120 125 Val Ala Ser Gly Gln Arg Gly Pro Thr Met Arg Ile Trp Asp Trp Asp     130 135 140 Asp Arg Ala Thr Val Ile Gly Ser Phe Gln Ser Tyr Val Asn Glu Ile 145 150 155 160 Asn Gln Glu Gly Val Asn Glu His Gly Val Thr Val Val Arg Arg Met                 165 170 175 Ser Gly Gly Gly Ala Met Phe Met Glu Gly Gly Asn Cys Ile Thr Tyr             180 185 190 Ser Leu Tyr Ala Pro Glu Ser Leu Val Ala Gly Leu Ser Tyr Glu Gln         195 200 205 Ser Tyr Glu Tyr Leu Asp Arg Trp Val Ile Ala Ala Leu Lys Thr His     210 215 220 Asp Val Asp Ala Trp Tyr Val Pro Ile Asn Asp Ile Thr Ser Thr Gly 225 230 235 240 Gly Lys Ile Gly Gly Ala Ala Gln Lys Arg Arg Ser Gly Ala Val Leu                 245 250 255 His His Val Thr Met Ser Tyr Asp Ile Asp Ala Asp Met Met Thr Gln             260 265 270 Val Leu Arg Ile Gly Lys Val Lys Ile Ser Asp Lys Gly Leu Arg Ser         275 280 285 Ala Lys Lys Arg Val Asp Pro Leu Arg Arg Gln Thr Gly Ala Ser Arg     290 295 300 Glu Gln Ile Ile Asp Thr Leu Lys Ser Thr Phe Ser Ala Arg Tyr Gly 305 310 315 320 Ala Gln Glu Val Glu Leu Ser Asp Glu Asp Phe Ala Ala Gly His Asp                 325 330 335 Leu Val Lys Thr Lys Tyr Ala Thr Glu Glu Trp Thr Lys Arg Val Gln             340 345 350 <210> 187 <211> 876 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (101) .. (853) <223> RXS01746 <400> 187 aaaccgccac tcccctttca ctggggagtg gcggttttgt cgtttcatgc atgcagtgtg 60 tgacttatca accttgttag ggctagggtg gatatctatc atg act gca cca aga 115                                             Met thr ala pro arg                                               1 5 gat cct ttt ttc ccc gca gat ctt tct atc cgc gcg tct gca gag ccc 163 Asp Pro Phe Phe Pro Ala Asp Leu Ser Ile Arg Ala Ser Ala Glu Pro                  10 15 20 att gaa att cag cgg ttg ggt ttg atc gat tat caa gag gcc tgg gat 211 Ile Glu Ile Gln Arg Leu Gly Leu Ile Asp Tyr Gln Glu Ala Trp Asp              25 30 35 tat caa gca gag ctt gct acc cgt agg gct aat gat gaa atc cct gat 259 Tyr Gln Ala Glu Leu Ala Thr Arg Arg Ala Asn Asp Glu Ile Pro Asp          40 45 50 cag ctg ctt att ttg gag cac ccg tcg gtg tat acc gca ggt aag cgc 307 Gln Leu Leu Ile Leu Glu His Pro Ser Val Tyr Thr Ala Gly Lys Arg      55 60 65 acc cag ccg gaa gat ctt ccc acc aac gga ctg ccg gtg atc aat gct 355 Thr Gln Pro Glu Asp Leu Pro Thr Asn Gly Leu Pro Val Ile Asn Ala  70 75 80 85 gat cgt ggt ggt cgc atc acg tgg cat ggt cct ggc caa ttg gtg atc 403 Asp Arg Gly Gly Arg Ile Thr Trp His Gly Pro Gly Gln Leu Val Ile                  90 95 100 tat ccg atc atc aaa tta gcc gat ccg atc gat gtg gtt gat tac gta 451 Tyr Pro Ile Ile Lys Leu Ala Asp Pro Ile Asp Val Val Asp Tyr Val             105 110 115 aga cgc ctc gag gaa gcg ctc atc caa gtt gtc ggc gat atg ggt gtt 499 Arg Arg Leu Glu Glu Ala Leu Ile Gln Val Val Gly Asp Met Gly Val         120 125 130 gcc ggc gct ggg cgc att gat ggg cgt tcg ggt gtg tgg gtg cca gct 547 Ala Gly Ala Gly Arg Ile Asp Gly Arg Ser Gly Val Trp Val Pro Ala     135 140 145 cat gat ggt tgg gtg gac agc aag gtt gcg gcc atc ggc att cga ata 595 His Asp Gly Trp Val Asp Ser Lys Val Ala Ala Ile Gly Ile Arg Ile 150 155 160 165 act cgt ggt gtt gca atg cac ggt gtg gcc atc aac tgc aac aac acg 643 Thr Arg Gly Val Ala Met His Gly Val Ala Ile Asn Cys Asn Asn Thr                 170 175 180 ttg gat ttc tat gag cac atc att ccg tgt ggc att gct gat gca ggc 691 Leu Asp Phe Tyr Glu His Ile Ile Pro Cys Gly Ile Ala Asp Ala Gly             185 190 195 ttg agc aca ctc tcg agg gaa ctg aaa agg gac gtt tca gtt gag gaa 739 Leu Ser Thr Leu Ser Arg Glu Leu Lys Arg Asp Val Ser Val Glu Glu         200 205 210 tta gtc gag cca tcg atc cgc gca ttg gat gat gct ttg gct ggt cgg 787 Leu Val Glu Pro Ser Ile Arg Ala Leu Asp Asp Ala Leu Ala Gly Arg     215 220 225 ctg gtt gtt tct gat cat tct ttc ggc agc gcg ccc gac cca act aag 835 Leu Val Val Ser Asp His Ser Phe Gly Ser Ala Pro Asp Pro Thr Lys 230 235 240 245 aat ctc cct aaa cgg ggg tagtacgagg aattttgtcg gtg 876 Asn Leu Pro Lys Arg Gly                 250 <210> 188 <211> 251 <212> PRT <213> Corynebacterium glutamicum <400> 188 Met Thr Ala Pro Arg Asp Pro Phe Phe Pro Ala Asp Leu Ser Ile Arg   1 5 10 15 Ala Ser Ala Glu Pro Ile Glu Ile Gln Arg Leu Gly Leu Ile Asp Tyr              20 25 30 Gln Glu Ala Trp Asp Tyr Gln Ala Glu Leu Ala Thr Arg Arg Ala Asn          35 40 45 Asp Glu Ile Pro Asp Gln Leu Leu Ile Leu Glu His Pro Ser Val Tyr      50 55 60 Thr Ala Gly Lys Arg Thr Gln Pro Glu Asp Leu Pro Thr Asn Gly Leu  65 70 75 80 Pro Val Ile Asn Ala Asp Arg Gly Gly Arg Ile Thr Trp His Gly Pro                  85 90 95 Gly Gln Leu Val Ile Tyr Pro Ile Ile Lys Leu Ala Asp Pro Ile Asp             100 105 110 Val Val Asp Tyr Val Arg Arg Leu Glu Glu Ala Leu Ile Gln Val Val         115 120 125 Gly Asp Met Gly Val Ala Gly Ala Gly Arg Ile Asp Gly Arg Ser Gly     130 135 140 Val Trp Val Pro Ala His Asp Gly Trp Val Asp Ser Lys Val Ala Ala 145 150 155 160 Ile Gly Ile Arg Ile Thr Arg Gly Val Ala Met His Gly Val Ala Ile                 165 170 175 Asn Cys Asn Asn Thr Leu Asp Phe Tyr Glu His Ile Ile Pro Cys Gly             180 185 190 Ile Ala Asp Ala Gly Leu Ser Thr Leu Ser Arg Glu Leu Lys Arg Asp         195 200 205 Val Ser Val Glu Glu Leu Val Glu Pro Ser Ile Arg Ala Leu Asp Asp     210 215 220 Ala Leu Ala Gly Arg Leu Val Val Ser Asp His Ser Phe Gly Ser Ala 225 230 235 240 Pro Asp Pro Thr Lys Asn Leu Pro Lys Arg Gly                 245 250 <210> 189 <211> 1167 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1144) <223> RXS01747 <400> 189 cgaagtagag ccgattgcag aatcggcgga atgagacgtc gaaaagcgtt taagctttcc 60 ctaaaaatat cactaactcg aaagatgtaa ggttgcattt gtg act atc gca cct 115                                             Val Thr Ile Ala Pro                                               1 5 gaa gga cga cga ctg cta cgc gtc gaa gct cga aac tca gaa acc ccg 163 Glu Gly Arg Arg Leu Leu Arg Val Glu Ala Arg Asn Ser Glu Thr Pro                  10 15 20 att gag acg aag cct cga tgg att aga aac cag gtc aaa aac gga cct 211 Ile Glu Thr Lys Pro Arg Trp Ile Arg Asn Gln Val Lys Asn Gly Pro              25 30 35 gag tat cag gat atg aag gaa cgt gtc gct ggc gca tca cta cac act 259 Glu Tyr Gln Asp Met Lys Glu Arg Val Ala Gly Ala Ser Leu His Thr          40 45 50 gtg tgt cag gag gct ggc tgt cct aat atc cat gag tgt tgg gaa tcc 307 Val Cys Gln Glu Ala Gly Cys Pro Asn Ile His Glu Cys Trp Glu Ser      55 60 65 cgt gag gca acc ttc ctc att ggt ggc gcc aac tgc tct cgc cgc tgt 355 Arg Glu Ala Thr Phe Leu Ile Gly Gly Ala Asn Cys Ser Arg Arg Cys  70 75 80 85 gat ttc tgc atg atc aac tcg gct cgc cct gag cca ctc gac cgc ggt 403 Asp Phe Cys Met Ile Asn Ser Ala Arg Pro Glu Pro Leu Asp Arg Gly                  90 95 100 gag cca ctg cgt gtc gct gag tct gtt cgt gag atg cag ctg aat tac 451 Glu Pro Leu Arg Val Ala Glu Ser Val Arg Glu Met Gln Leu Asn Tyr             105 110 115 tcc acc atc acc ggt gtt acc cgt gat gat ctg gat gat gaa ggc gca 499 Ser Thr Ile Thr Gly Val Thr Arg Asp Asp Leu Asp Asp Glu Gly Ala         120 125 130 tgg ctg tac tca gaa gtg gtt cgt aag atc cac gag ctg aac cca cac 547 Trp Leu Tyr Ser Glu Val Val Arg Lys Ile His Glu Leu Asn Pro His     135 140 145 acc ggt gtg gaa aac ctg gtg cct gat ttc tcc ggc aag aag gat ctg 595 Thr Gly Val Glu Asn Leu Val Pro Asp Phe Ser Gly Lys Lys Asp Leu 150 155 160 165 ctg cag gaa gtt ttt gaa tcc cgc cca gag gtt ttc gct cac aac gtg 643 Leu Gln Glu Val Phe Glu Ser Arg Pro Glu Val Phe Ala His Asn Val                 170 175 180 gaa act gtg cca cgt att ttc aag cgc att cgc cca gca ttc cgc tac 691 Glu Thr Val Pro Arg Ile Phe Lys Arg Ile Arg Pro Ala Phe Arg Tyr             185 190 195 gag cgt tca ctt gat gtg atc cgt cag gct cgc gat ttc ggt ctg gtg 739 Glu Arg Ser Leu Asp Val Ile Arg Gln Ala Arg Asp Phe Gly Leu Val         200 205 210 acc aag tcc aac ctg att ttg ggc atg ggt gaa acc aag gaa gaa atc 787 Thr Lys Ser Asn Leu Ile Leu Gly Met Gly Glu Thr Lys Glu Glu Ile     215 220 225 acc gag gcg ctg cag gat ctg cac gac gct ggc tgt gac atc atc acc 835 Thr Glu Ala Leu Gln Asp Leu His Asp Ala Gly Cys Asp Ile Ile Thr 230 235 240 245 atc acc cag tac ctg cgt cct ggt cct ttg ttc cac ccc atc gag cgt 883 Ile Thr Gln Tyr Leu Arg Pro Gly Pro Leu Phe His Pro Ile Glu Arg                 250 255 260 tgg gtg aag cct gag gag ttc ctc gag cac gct gat gct gca aag gaa 931 Trp Val Lys Pro Glu Glu Phe Leu Glu His Ala Asp Ala Ala Lys Glu             265 270 275 atg ggc ttc gct gct gtt atg tcc ggc cca ttg gtt cgt tcc tct tac 979 Met Gly Phe Ala Ala Val Met Ser Gly Pro Leu Val Arg Ser Ser Tyr         280 285 290 cgt gca ggc cgt ctg tac gcg cag gcc atg gag ttc cgt ggc gag gaa 1027 Arg Ala Gly Arg Leu Tyr Ala Gln Ala Met Glu Phe Arg Gly Glu Glu     295 300 305 atc cca gca cac ctc gcg cac ctg aag gat act tcc gga gga tcc acc 1075 Ile Pro Ala His Leu Ala His Leu Lys Asp Thr Ser Gly Gly Ser Thr 310 315 320 325 gcc cag gaa gca tct aca ctt ctg gag cgt tac ggt gct tcc gaa gac 1123 Ala Gln Glu Ala Ser Thr Leu Leu Glu Arg Tyr Gly Ala Ser Glu Asp                 330 335 340 acc cca gtg gtg tcc ttc aac taagcccgaa gttttttaac cgc 1167 Thr Pro Val Val Ser Phe Asn             345 <210> 190 <211> 348 <212> PRT <213> Corynebacterium glutamicum <400> 190 Val Thr Ile Ala Pro Glu Gly Arg Arg Leu Leu Arg Val Glu Ala Arg   1 5 10 15 Asn Ser Glu Thr Pro Ile Glu Thr Lys Pro Arg Trp Ile Arg Asn Gln              20 25 30 Val Lys Asn Gly Pro Glu Tyr Gln Asp Met Lys Glu Arg Val Ala Gly          35 40 45 Ala Ser Leu His Thr Val Cys Gln Glu Ala Gly Cys Pro Asn Ile His      50 55 60 Glu Cys Trp Glu Ser Arg Glu Ala Thr Phe Leu Ile Gly Gly Ala Asn  65 70 75 80 Cys Ser Arg Arg Cys Asp Phe Cys Met Ile Asn Ser Ala Arg Pro Glu                  85 90 95 Pro Leu Asp Arg Gly Glu Pro Leu Arg Val Ala Glu Ser Val Arg Glu             100 105 110 Met Gln Leu Asn Tyr Ser Thr Ile Thr Gly Val Thr Arg Asp Asp Leu         115 120 125 Asp Asp Glu Gly Ala Trp Leu Tyr Ser Glu Val Val Arg Lys Ile His     130 135 140 Glu Leu Asn Pro His Thr Gly Val Glu Asn Leu Val Pro Asp Phe Ser 145 150 155 160 Gly Lys Lys Asp Leu Leu Gln Glu Val Phe Glu Ser Arg Pro Glu Val                 165 170 175 Phe Ala His Asn Val Glu Thr Val Pro Arg Ile Phe Lys Arg Ile Arg             180 185 190 Pro Ala Phe Arg Tyr Glu Arg Ser Leu Asp Val Ile Arg Gln Ala Arg         195 200 205 Asp Phe Gly Leu Val Thr Lys Ser Asn Leu Ile Leu Gly Met Gly Glu     210 215 220 Thr Lys Glu Glu Ile Thr Glu Ala Leu Gln Asp Leu His Asp Ala Gly 225 230 235 240 Cys Asp Ile Ile Thr Ile Thr Gln Tyr Leu Arg Pro Gly Pro Leu Phe                 245 250 255 His Pro Ile Glu Arg Trp Val Lys Pro Glu Glu Phe Leu Glu His Ala             260 265 270 Asp Ala Ala Lys Glu Met Gly Phe Ala Ala Val Met Ser Gly Pro Leu         275 280 285 Val Arg Ser Ser Tyr Arg Ala Gly Arg Leu Tyr Ala Gln Ala Met Glu     290 295 300 Phe Arg Gly Glu Glu Ile Pro Ala His Leu Ala His Leu Lys Asp Thr 305 310 315 320 Ser Gly Gly Ser Thr Ala Gln Glu Ala Ser Thr Leu Leu Glu Arg Tyr                 325 330 335 Gly Ala Ser Glu Asp Thr Pro Val Val Ser Phe Asn             340 345 <210> 191 <211> 903 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (880) <223> RXC01748 <400> 191 atcaccaaat gtggcggttt tgcgtcgaaa agcgtgctct ttctacacct ctttgaggtt 60 cattttcgcg gtttcctcac aatcgcctat tgttaagtac atg gca gac gcg aaa 115                                             Met Ala Asp Ala Lys                                               1 5 aag cag gcg gat aaa gcc gcc aag aag cag gta aga gca gcc aag aag 163 Lys Gln Ala Asp Lys Ala Ala Lys Lys Gln Val Arg Ala Ala Lys Lys                  10 15 20 gca cag cgc aag gag act cgc tca caa atg tgg cag gtc ttc aac atg 211 Ala Gln Arg Lys Glu Thr Arg Ser Gln Met Trp Gln Val Phe Asn Met              25 30 35 caa cgc aag cag gat aag gct ctt att ccg ctt ctg ttg ctc gct att 259 Gln Arg Lys Gln Asp Lys Ala Leu Ile Pro Leu Leu Leu Leu Ala Ile          40 45 50 ctt ggt atc ccg ctg gtc ctt ttc ctc atc ggt ttg att tgg ggt ggt 307 Leu Gly Ile Pro Leu Val Leu Phe Leu Ile Gly Leu Ile Trp Gly Gly      55 60 65 cag tgg tgg atg ctt ccg atc ggc att gct gca ggt gtt gta gct gca 355 Gln Trp Trp Met Leu Pro Ile Gly Ile Ala Ala Gly Val Val Ala Ala  70 75 80 85 atg ttt att ttc acc cgt cgc gtt gag cgt gac gtg tac aag cgc gcc 403 Met Phe Ile Phe Thr Arg Arg Val Glu Arg Asp Val Tyr Lys Arg Ala                  90 95 100 gaa ggt cag cag ggt gct gct ggt tgg gct gtg gag aac ctc cgc tct 451 Glu Gly Gln Gln Gly Ala Ala Gly Trp Ala Val Glu Asn Leu Arg Ser             105 110 115 ggc gtg ggc atg acc tgg cgc acc aag acc gct gtt gca gtg acc act 499 Gly Val Gly Met Thr Trp Arg Thr Lys Thr Ala Val Ala Val Thr Thr         120 125 130 cag atg gat gca gtg cac cgc gtc att ggt ctg tgt ggt gtt gtg ctg 547 Gln Met Asp Ala Val His Arg Val Ile Gly Leu Cys Gly Val Val Leu     135 140 145 gtc ggc gag ggc tcc cct cac cgc ctg aag cca atg ctt gcg cag caa 595 Val Gly Glu Gly Ser Pro His Arg Leu Lys Pro Met Leu Ala Gln Gln 150 155 160 165 aag aag cgc ctg aac cgc gtg gca cct ggt gtt cca gtg tat gaa atc 643 Lys Lys Arg Leu Asn Arg Val Ala Pro Gly Val Pro Val Tyr Glu Ile                 170 175 180 atc acg ggc aac ggc gaa ggc cag acc cct atc gcg aag ctg cag cgt 691 Ile Thr Gly Asn Gly Glu Gly Gln Thr Pro Ile Ala Lys Leu Gln Arg             185 190 195 gaa ctg gtc aag ctg cct cgc aac tac aag aag aac gac gtc gct gcc 739 Glu Leu Val Lys Leu Pro Arg Asn Tyr Lys Lys Asn Asp Val Ala Ala         200 205 210 ctg gcc gct cgc att gag gct atg gac aat gtc gga aac gct cct ggc 787 Leu Ala Ala Arg Ile Glu Ala Met Asp Asn Val Gly Asn Ala Pro Gly     215 220 225 gga tct ttg cct aag ggt cca ttg cca aag ggc gca agc atg tcc ggt 835 Gly Ser Leu Pro Lys Gly Pro Leu Pro Lys Gly Ala Ser Met Ser Gly 230 235 240 245 atg aac cgc cgc gct cgc cga cag gct gaa cgc aag ggc gag gct 880 Met Asn Arg Arg Ala Arg Arg Gln Ala Glu Arg Lys Gly Glu Ala                 250 255 260 taaagccttt tcgctttcgc gtc 903 <210> 192 <211> 260 <212> PRT <213> Corynebacterium glutamicum <400> 192 Met Ala Asp Ala Lys Lys Gln Ala Asp Lys Ala Ala Lys Lys Gln Val   1 5 10 15 Arg Ala Ala Lys Lys Ala Gln Arg Lys Glu Thr Arg Ser Gln Met Trp              20 25 30 Gln Val Phe Asn Met Gln Arg Lys Gln Asp Lys Ala Leu Ile Pro Leu          35 40 45 Leu Leu Leu Ala Ile Leu Gly Ile Pro Leu Val Leu Phe Leu Ile Gly      50 55 60 Leu Ile Trp Gly Gly Gln Trp Trp Met Leu Pro Ile Gly Ile Ala Ala  65 70 75 80 Gly Val Val Ala Ala Met Phe Ile Phe Thr Arg Arg Val Glu Arg Asp                  85 90 95 Val Tyr Lys Arg Ala Glu Gly Gln Gln Gly Ala Ala Gly Trp Ala Val             100 105 110 Glu Asn Leu Arg Ser Gly Val Gly Met Thr Trp Arg Thr Lys Thr Ala         115 120 125 Val Ala Val Thr Thr Gln Met Asp Ala Val His Arg Val Ile Gly Leu     130 135 140 Cys Gly Val Val Leu Val Gly Glu Gly Ser Pro His Arg Leu Lys Pro 145 150 155 160 Met Leu Ala Gln Gln Lys Lys Arg Leu Asn Arg Val Ala Pro Gly Val                 165 170 175 Pro Val Tyr Glu Ile Ile Thr Gly Asn Gly Glu Gly Gln Thr Pro Ile             180 185 190 Ala Lys Leu Gln Arg Glu Leu Val Lys Leu Pro Arg Asn Tyr Lys Lys         195 200 205 Asn Asp Val Ala Ala Leu Ala Ala Arg Ile Glu Ala Met Asp Asn Val     210 215 220 Gly Asn Ala Pro Gly Gly Ser Leu Pro Lys Gly Pro Leu Pro Lys Gly 225 230 235 240 Ala Ser Met Ser Gly Met Asn Arg Arg Ala Arg Arg Gln Ala Glu Arg                 245 250 255 Lys Gly Glu Ala             260 <210> 193 <211> 936 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (913) <223> RXC00354 <400> 193 ggcttgtcgg taaggctgca gggtagcggg agtttccttc agattggaag ttctttaatt 60 ttctcgatta tgtacctcat ttacgcgtaa agtttggggc atg gga aag tta ctt 115                                             Met Gly Lys Leu Leu                                               1 5 ttc gta gac atc ggt ggc aca ctg ctg gat tac tca aat gaa gtt ccg 163 Phe Val Asp Ile Gly Gly Thr Leu Leu Asp Tyr Ser Asn Glu Val Pro                  10 15 20 cgt tcg gcc gtt gac gcg atc cgt aag gca cgc gcc aaa gga cac cgc 211 Arg Ser Ala Val Asp Ala Ile Arg Lys Ala Arg Ala Lys Gly His Arg              25 30 35 gtg tac ttg agc tct ggt cga agc agc gct gag gtg act tct cag ttg 259 Val Tyr Leu Ser Ser Gly Arg Ser Ser Ala Glu Val Thr Ser Gln Leu          40 45 50 tgg gat atc gga gtg gat ggc ctc att ggc gca aat ggt gga tat gtg 307 Trp Asp Ile Gly Val Asp Gly Leu Ile Gly Ala Asn Gly Gly Tyr Val      55 60 65 gaa agc gca cag gag tct gtg ttc cac cgc cgt ttg tcg ggt gag gag 355 Glu Ser Ala Gln Glu Ser Val Phe His Arg Arg Leu Ser Gly Glu Glu  70 75 80 85 acc cgc cac att gtg gag tgg ctc tac aac cgt ggt ttg gag ttt tat 403 Thr Arg His Ile Val Glu Trp Leu Tyr Asn Arg Gly Leu Glu Phe Tyr                  90 95 100 ctc gag tcc aac aac ggt ttg tat gca agc cgt ggt ttc cgt gag gct 451 Leu Glu Ser Asn Asn Gly Leu Tyr Ala Ser Arg Gly Phe Arg Glu Ala             105 110 115 tct aag cca gtg ctg tct cgc ctt tcg gag aag acc gac gtg aca gtc 499 Ser Lys Pro Val Leu Ser Arg Leu Ser Glu Lys Thr Asp Val Thr Val         120 125 130 gat agc atg tac ccg gat atg ttc tgg ggc gcg agc ctt gat cgt gac 547 Asp Ser Met Tyr Pro Asp Met Phe Trp Gly Ala Ser Leu Asp Arg Asp     135 140 145 gat gtg aac aag atc agt tac atc ttc aat tct cag gaa gat ttg gac 595 Asp Val Asn Lys Ile Ser Tyr Ile Phe Asn Ser Gln Glu Asp Leu Asp 150 155 160 165 gca gcg cgt gag gcg ttc cct aac ctg gag cac acc acg tgg ggt ggt 643 Ala Ala Arg Glu Ala Phe Pro Asn Leu Glu His Thr Thr Trp Gly Gly                 170 175 180 cag acg ggt gcg ttg ttc ggc acg atc ggt gtg tct gtc aac aag aag 691 Gln Thr Gly Ala Leu Phe Gly Thr Ile Gly Val Ser Val Asn Lys Lys             185 190 195 atc ggc gtg gat cgc ctg ctg aag tac ctg aac gca gat cgc gca aac 739 Ile Gly Val Asp Arg Leu Leu Lys Tyr Leu Asn Ala Asp Arg Ala Asn         200 205 210 acc att gcg ttc ggc gac agc gat gag gat ctc tcc cta ttt gag gcg 787 Thr Ile Ala Phe Gly Asp Ser Asp Glu Asp Leu Ser Leu Phe Glu Ala     215 220 225 agc gct tac ggc gtc gcg atg ggc gag gcc acc gaa tcg ctc aag gct 835 Ser Ala Tyr Gly Val Ala Met Gly Glu Ala Thr Glu Ser Leu Lys Ala 230 235 240 245 gct gct gac ctg gtc acg gat gct gtt ggg cag gac ggc ttg cgc aat 883 Ala Ala Asp Leu Val Thr Asp Ala Val Gly Gln Asp Gly Leu Arg Asn                 250 255 260 gcg ttt tta aag ctt gag ctt atc gac gcc tgaccccatc aaagaacttc 933 Ala Phe Leu Lys Leu Glu Leu Ile Asp Ala             265 270 cca 936 <210> 194 <211> 271 <212> PRT <213> Corynebacterium glutamicum <400> 194 Met Gly Lys Leu Leu Phe Val Asp Ile Gly Gly Thr Leu Leu Asp Tyr   1 5 10 15 Ser Asn Glu Val Pro Arg Ser Ala Val Asp Ala Ile Arg Lys Ala Arg              20 25 30 Ala Lys Gly His Arg Val Tyr Leu Ser Ser Gly Arg Ser Ser Ala Glu          35 40 45 Val Thr Ser Gln Leu Trp Asp Ile Gly Val Asp Gly Leu Ile Gly Ala      50 55 60 Asn Gly Gly Tyr Val Glu Ser Ala Gln Glu Ser Val Phe His Arg Arg  65 70 75 80 Leu Ser Gly Glu Glu Thr Arg His Ile Val Glu Trp Leu Tyr Asn Arg                  85 90 95 Gly Leu Glu Phe Tyr Leu Glu Ser Asn Asn Gly Leu Tyr Ala Ser Arg             100 105 110 Gly Phe Arg Glu Ala Ser Lys Pro Val Leu Ser Arg Leu Ser Glu Lys         115 120 125 Thr Asp Val Thr Val Asp Ser Met Tyr Pro Asp Met Phe Trp Gly Ala     130 135 140 Ser Leu Asp Arg Asp Asp Val Asn Lys Ile Ser Tyr Ile Phe Asn Ser 145 150 155 160 Gln Glu Asp Leu Asp Ala Ala Arg Glu Ala Phe Pro Asn Leu Glu His                 165 170 175 Thr Thr Trp Gly Gly Gln Thr Gly Ala Leu Phe Gly Thr Ile Gly Val             180 185 190 Ser Val Asn Lys Lys Ile Gly Val Asp Arg Leu Leu Lys Tyr Leu Asn         195 200 205 Ala Asp Arg Ala Asn Thr Ile Ala Phe Gly Asp Ser Asp Glu Asp Leu     210 215 220 Ser Leu Phe Glu Ala Ser Ala Tyr Gly Val Ala Met Gly Glu Ala Thr 225 230 235 240 Glu Ser Leu Lys Ala Ala Ala Asp Leu Val Thr Asp Ala Val Gly Gln                 245 250 255 Asp Gly Leu Arg Asn Ala Phe Leu Lys Leu Glu Leu Ile Asp Ala             260 265 270 <210> 195 <211> 1740 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1717) <223> RXC01749 <400> 195 ggtttttgcg tgctctggtt tagggactgg ttttgggaac gtgcccagtt ccacatcaaa 60 taacgctgag gtcgtactta atccatgaga tcatgaatgg gtg agc ttc ctt gta 115                                             Val Ser Phe Leu Val                                               1 5 gaa aat caa tta ctc gcg ttg gtt gtc atc atg acg gtc gga cta ttg 163 Glu Asn Gln Leu Leu Ala Leu Val Val Ile Met Thr Val Gly Leu Leu                  10 15 20 ctc ggc cgc atc aaa att ttc ggg ttc cgt ctc ggc gtc gcc gct gta 211 Leu Gly Arg Ile Lys Ile Phe Gly Phe Arg Leu Gly Val Ala Ala Val              25 30 35 ctg ttt gta ggt cta gcg cta tcc acc att gag ccg gat att tcc gtc 259 Leu Phe Val Gly Leu Ala Leu Ser Thr Ile Glu Pro Asp Ile Ser Val          40 45 50 cca tcc ctc att tac gtg gtt gga ctg tcg ctt ttt gtc tac acg atc 307 Pro Ser Leu Ile Tyr Val Val Gly Leu Ser Leu Phe Val Tyr Thr Ile      55 60 65 ggt ctg gaa gcc ggc cct gga ttc ttc acc tcc atg aaa acc act ggt 355 Gly Leu Glu Ala Gly Pro Gly Phe Phe Thr Ser Met Lys Thr Thr Gly  70 75 80 85 ctg cgc aac aac gca ctg acc ttg ggc gcc atc atc gcc acc acg gca 403 Leu Arg Asn Asn Ala Leu Thr Leu Gly Ala Ile Ile Ala Thr Thr Ala                  90 95 100 ctc gca tgg gca ctc atc aca gtt ttg aac atc gat gcc gcc tcc ggc 451 Leu Ala Trp Ala Leu Ile Thr Val Leu Asn Ile Asp Ala Ala Ser Gly             105 110 115 gcc ggc atg ctc acc ggc gcg ctc acc aac acc cca gcc atg gcc gca 499 Ala Gly Met Leu Thr Gly Ala Leu Thr Asn Thr Pro Ala Met Ala Ala         120 125 130 gtt gtt gac gca ctt cct tcg ctt atc gac gac acc ggc cag ctt cac 547 Val Val Asp Ala Leu Pro Ser Leu Ile Asp Asp Thr Gly Gln Leu His     135 140 145 ctc atc gcc gag ctg ccc gtc gtc gca tat tcc ttg gca tac ccc ctc 595 Leu Ile Ala Glu Leu Pro Val Val Ala Tyr Ser Leu Ala Tyr Pro Leu 150 155 160 165 ggt gtg ctc atc gtt att ctc tcc atc gcc atc ttc agc tct gtg ttc 643 Gly Val Leu Ile Val Ile Leu Ser Ile Ala Ile Phe Ser Ser Val Phe                 170 175 180 aaa gtc gac cac aac aaa gaa gcc gaa gaa gcg ggc gtt gcg gtc cag 691 Lys Val Asp His Asn Lys Glu Ala Glu Glu Ala Gly Val Ala Val Gln             185 190 195 gaa ctc aaa ggc cgt cgc atc cgc gtc acc gtc gct gat ctt cca gcc 739 Glu Leu Lys Gly Arg Arg Ile Arg Val Thr Val Ala Asp Leu Pro Ala         200 205 210 ctg gag aac atc cca gag ctg ctc aac ctc cac gtc att gtg tcc cga 787 Leu Glu Asn Ile Pro Glu Leu Leu Asn Leu His Val Ile Val Ser Arg     215 220 225 gtg gaa cga gac ggt gag caa ttc atc ccg ctt tat ggc gaa cac gca 835 Val Glu Arg Asp Gly Glu Gln Phe Ile Pro Leu Tyr Gly Glu His Ala 230 235 240 245 cgc atc ggc gat gtc tta aca gtg gtg ggt gcc gat gaa gaa ctc aac 883 Arg Ile Gly Asp Val Leu Thr Val Val Gly Ala Asp Glu Glu Leu Asn                 250 255 260 cgc gcg gaa aaa gcc atc ggt gaa ctc att gac ggc gac ccc tac agc 931 Arg Ala Glu Lys Ala Ile Gly Glu Leu Ile Asp Gly Asp Pro Tyr Ser             265 270 275 aat gtg gaa ctt gat tac cga cgc atc ttc gtc tca aac aca gca gtc 979 Asn Val Glu Leu Asp Tyr Arg Arg Ile Phe Val Ser Asn Thr Ala Val         280 285 290 gtg ggc act ccc cta tcc aag ctc cag cca ctg ttt aaa gac atg ctg 1027 Val Gly Thr Pro Leu Ser Lys Leu Gln Pro Leu Phe Lys Asp Met Leu     295 300 305 atc acc cgc atc agg cgc ggc gac aca gat ttg gtg gcc tcc tcc gac 1075 Ile Thr Arg Ile Arg Arg Gly Asp Thr Asp Leu Val Ala Ser Ser Asp 310 315 320 325 atg act ttg cag ctc ggt gac cgt gtc cgc gtt gtc gca cca gca gaa 1123 Met Thr Leu Gln Leu Gly Asp Arg Val Arg Val Val Ala Pro Ala Glu                 330 335 340 aaa ctc cgc gaa gca acc caa ttg ctc ggc gat tcc tac aag aaa ctc 1171 Lys Leu Arg Glu Ala Thr Gln Leu Leu Gly Asp Ser Tyr Lys Lys Leu             345 350 355 tcc gat ttc aac ctg ctc cca ctc gct gcc ggc ctc atg atc ggt gtg 1219 Ser Asp Phe Asn Leu Leu Pro Leu Ala Ala Gly Leu Met Ile Gly Val         360 365 370 ctt gtc ggc atg gtg gag ttc cca cta cca ggt gga agc tcc ctg aaa 1267 Leu Val Gly Met Val Glu Phe Pro Leu Pro Gly Gly Ser Ser Leu Lys     375 380 385 ctg ggt aac gca ggt gga ccg cta gtt gtt gcg ctg ctg ctc ggc atg 1315 Leu Gly Asn Ala Gly Gly Pro Leu Val Val Ala Leu Leu Leu Gly Met 390 395 400 405 atc aat cgc aca ggc aag ttc gtc tgg caa atc ccc tac gga gca aac 1363 Ile Asn Arg Thr Gly Lys Phe Val Trp Gln Ile Pro Tyr Gly Ala Asn                 410 415 420 ctt gcc ctt cgc caa ctg ggc atc aca cta ttt ttg gct gcc atc ggt 1411 Leu Ala Leu Arg Gln Leu Gly Ile Thr Leu Phe Leu Ala Ala Ile Gly             425 430 435 acc tca gcg ggc gca gga ttt cga tca gcg atc agc gac ccc caa tca 1459 Thr Ser Ala Gly Ala Gly Phe Arg Ser Ala Ile Ser Asp Pro Gln Ser         440 445 450 ctc acc atc atc ggc ttc ggt gcg ctg ctc act ttg ttc atc tcc atc 1507 Leu Thr Ile Ile Gly Phe Gly Ala Leu Leu Thr Leu Phe Ile Ser Ile     455 460 465 acg gtg ctg ttc gtt ggc cac aaa ctg atg aaa atc ccc ttc ggt gaa 1555 Thr Val Leu Phe Val Gly His Lys Leu Met Lys Ile Pro Phe Gly Glu 470 475 480 485 acc gct ggc atc ctc gcc ggt acg caa acc cac cct gct gtg ctg agt 1603 Thr Ala Gly Ile Leu Ala Gly Thr Gln Thr His Pro Ala Val Leu Ser                 490 495 500 tat gtg tca gat gcc tcc cgc aac gag ctc cct gcc atg ggt tat acc 1651 Tyr Val Ser Asp Ala Ser Arg Asn Glu Leu Pro Ala Met Gly Tyr Thr             505 510 515 tct gtg tat ccg ctg gcg atg atc gca aag atc ctg gcc gcc caa acg 1699 Ser Val Tyr Pro Leu Ala Met Ile Ala Lys Ile Leu Ala Ala Gln Thr         520 525 530 ttg ttg ttc cta ctt atc tagcattgac cccttaagcg cag 1740 Leu Leu Phe Leu Leu Ile     535 <210> 196 <211> 539 <212> PRT <213> Corynebacterium glutamicum <400> 196 Val Ser Phe Leu Val Glu Asn Gln Leu Leu Ala Leu Val Val Ile Met   1 5 10 15 Thr Val Gly Leu Leu Leu Gly Arg Ile Lys Ile Phe Gly Phe Arg Leu              20 25 30 Gly Val Ala Ala Val Leu Phe Val Gly Leu Ala Leu Ser Thr Ile Glu          35 40 45 Pro Asp Ile Ser Val Pro Ser Leu Ile Tyr Val Val Gly Leu Ser Leu      50 55 60 Phe Val Tyr Thr Ile Gly Leu Glu Ala Gly Pro Gly Phe Phe Thr Ser  65 70 75 80 Met Lys Thr Thr Gly Leu Arg Asn Asn Ala Leu Thr Leu Gly Ala Ile                  85 90 95 Ile Ala Thr Thr Ala Leu Ala Trp Ala Leu Ile Thr Val Leu Asn Ile             100 105 110 Asp Ala Ala Ser Gly Ala Gly Met Leu Thr Gly Ala Leu Thr Asn Thr         115 120 125 Pro Ala Met Ala Ala Val Val Asp Ala Leu Pro Ser Leu Ile Asp Asp     130 135 140 Thr Gly Gln Leu His Leu Ile Ala Glu Leu Pro Val Val Ala Tyr Ser 145 150 155 160 Leu Ala Tyr Pro Leu Gly Val Leu Ile Val Ile Leu Ser Ile Ala Ile                 165 170 175 Phe Ser Ser Val Phe Lys Val Asp His Asn Lys Glu Ala Glu Glu Ala             180 185 190 Gly Val Ala Val Gln Glu Leu Lys Gly Arg Arg Ile Arg Val Thr Val         195 200 205 Ala Asp Leu Pro Ala Leu Glu Asn Ile Pro Glu Leu Leu Asn Leu His     210 215 220 Val Ile Val Ser Arg Val Glu Arg Asp Gly Glu Gln Phe Ile Pro Leu 225 230 235 240 Tyr Gly Glu His Ala Arg Ile Gly Asp Val Leu Thr Val Val Gly Ala                 245 250 255 Asp Glu Glu Leu Asn Arg Ala Glu Lys Ala Ile Gly Glu Leu Ile Asp             260 265 270 Gly Asp Pro Tyr Ser Asn Val Glu Leu Asp Tyr Arg Arg Ile Phe Val         275 280 285 Ser Asn Thr Ala Val Val Gly Thr Pro Leu Ser Lys Leu Gln Pro Leu     290 295 300 Phe Lys Asp Met Leu Ile Thr Arg Ile Arg Arg Gly Asp Thr Asp Leu 305 310 315 320 Val Ala Ser Ser Asp Met Thr Leu Gln Leu Gly Asp Arg Val Arg Val                 325 330 335 Val Ala Pro Ala Glu Lys Leu Arg Glu Ala Thr Gln Leu Leu Gly Asp             340 345 350 Ser Tyr Lys Lys Leu Ser Asp Phe Asn Leu Leu Pro Leu Ala Ala Gly         355 360 365 Leu Met Ile Gly Val Leu Val Gly Met Val Glu Phe Pro Leu Pro Gly     370 375 380 Gly Ser Ser Leu Lys Leu Gly Asn Ala Gly Gly Pro Leu Val Val Ala 385 390 395 400 Leu Leu Leu Gly Met Ile Asn Arg Thr Gly Lys Phe Val Trp Gln Ile                 405 410 415 Pro Tyr Gly Ala Asn Leu Ala Leu Arg Gln Leu Gly Ile Thr Leu Phe             420 425 430 Leu Ala Ala Ile Gly Thr Ser Ala Gly Ala Gly Phe Arg Ser Ala Ile         435 440 445 Ser Asp Pro Gln Ser Leu Thr Ile Ile Gly Phe Gly Ala Leu Leu Thr     450 455 460 Leu Phe Ile Ser Ile Thr Val Leu Phe Val Gly His Lys Leu Met Lys 465 470 475 480 Ile Pro Phe Gly Glu Thr Ala Gly Ile Leu Ala Gly Thr Gln Thr His                 485 490 495 Pro Ala Val Leu Ser Tyr Val Ser Asp Ala Ser Arg Asn Glu Leu Pro             500 505 510 Ala Met Gly Tyr Thr Ser Val Tyr Pro Leu Ala Met Ile Ala Lys Ile         515 520 525 Leu Ala Ala Gln Thr Leu Leu Phe Leu Leu Ile     530 535 <210> 197 <211> 1023 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (1000) <223> RXA02268 <400> 197 tgaatcgttg gtgcttcgag ttgggattgt tatgtgggga gacgtcgata agcaaaacac 60 ttgccgagcg caagccggcc tacggcgcta gtgtgagcac atg tcc cag gaa aat 115                                             Met Ser Gln Glu Asn                                               1 5 tct ggt ttg ttc aag cgc gcg att aca cgt ggg gtg gct aag gtg cgc 163 Ser Gly Leu Phe Lys Arg Ala Ile Thr Arg Gly Val Ala Lys Val Arg                  10 15 20 cgg aat ccg cgc gag gat ttt gcg gag gaa ttc acc caa gaa ctc tac 211 Arg Asn Pro Arg Glu Asp Phe Ala Glu Glu Phe Thr Gln Glu Leu Tyr              25 30 35 gat cac gca aca aat atc acc ctg ccc ctg acg gcg cgg ctg aag ccg 259 Asp His Ala Thr Asn Ile Thr Leu Pro Leu Thr Ala Arg Leu Lys Pro          40 45 50 aat ggg ttt ttc cag gat gat tgg cgg gcg cga cca agt ggt gcg cga 307 Asn Gly Phe Phe Gln Asp Asp Trp Arg Ala Arg Pro Ser Gly Ala Arg      55 60 65 ccg tgg ccg atc gtg cta att cac gga tcc ggg gcc agc aag ggt tca 355 Pro Trp Pro Ile Val Leu Ile His Gly Ser Gly Ala Ser Lys Gly Ser  70 75 80 85 tgg gag gaa atg ggc gct gag ctg cgc agc aaa ggt tgg gcc gtg ttt 403 Trp Glu Glu Met Gly Ala Glu Leu Arg Ser Lys Gly Trp Ala Val Phe                  90 95 100 gcc cct gac ttt gga acg cgt gcc acc gag cca att gcg gcg tcg gct 451 Ala Pro Asp Phe Gly Thr Arg Ala Thr Glu Pro Ile Ala Ala Ser Ala             105 110 115 gcc caa att ggt gcg tat att gat gcc gtt ttg ttg gtg acg ggc gct 499 Ala Gln Ile Gly Ala Tyr Ile Asp Ala Val Leu Leu Val Thr Gly Ala         120 125 130 gcg cag att gtg ctg gtt ggg cat tcg caa ggc ggt gtc gtg gcg cgg 547 Ala Gln Ile Val Leu Val Gly His Ser Gln Gly Gly Val Val Ala Arg     135 140 145 tat tgg atg cgc acc tac ggc gga tac atg aag gtc agg cac atg att 595 Tyr Trp Met Arg Thr Tyr Gly Gly Tyr Met Lys Val Arg His Met Ile 150 155 160 165 tcc atc tct acg cca aat cac gga acg ctc atg gga ggc att tta aac 643 Ser Ile Ser Thr Pro Asn His Gly Thr Leu Met Gly Gly Ile Leu Asn                 170 175 180 ccg atg acg aag gtg aaa tcg gga gag gga acg atc gaa aag ctg atg 691 Pro Met Thr Lys Val Lys Ser Gly Glu Gly Thr Ile Glu Lys Leu Met             185 190 195 cac aga cta ttc ggg ccc act ggt ttt gaa cag ctg cgc gga cac gac 739 His Arg Leu Phe Gly Pro Thr Gly Phe Glu Gln Leu Arg Gly His Asp         200 205 210 atc atc gag ttt ttg gcc gac ggt ggg gac ctc gat cca ggc gtc acc 787 Ile Ile Glu Phe Leu Ala Asp Gly Gly Asp Leu Asp Pro Gly Val Thr     215 220 225 tac acc tgc att ggt acc cat ttt gat cct ttc atc caa cct ccg gag 835 Tyr Thr Cys Ile Gly Thr His Phe Asp Pro Phe Ile Gln Pro Pro Glu 230 235 240 245 gtg gcc ttt ttg gag gtc aac gag gac gat gat cca aat cga gtc cac 883 Val Ala Phe Leu Glu Val Asn Glu Asp Asp Asp Pro Asn Arg Val His                 250 255 260 aat att tgg gtc gaa gat gaa cac ccg cgc gca atg att gcc cac aac 931 Asn Ile Trp Val Glu Asp Glu His Pro Arg Ala Met Ile Ala His Asn             265 270 275 gat atg gtg cgc gat ccc agg gtg atc gaa atc gta cgc gca gag ctc 979 Asp Met Val Arg Asp Pro Arg Val Ile Glu Ile Val Arg Ala Glu Leu         280 285 290 gac cgg gtg gca cgc ctc ggc taagttgggg acatggttga cgc 1023 Asp Arg Val Ala Arg Leu Gly     295 300 <210> 198 <211> 300 <212> PRT <213> Corynebacterium glutamicum <400> 198 Met Ser Gln Glu Asn Ser Gly Leu Phe Lys Arg Ala Ile Thr Arg Gly   1 5 10 15 Val Ala Lys Val Arg Arg Asn Pro Arg Glu Asp Phe Ala Glu Glu Phe              20 25 30 Thr Gln Glu Leu Tyr Asp His Ala Thr Asn Ile Thr Leu Pro Leu Thr          35 40 45 Ala Arg Leu Lys Pro Asn Gly Phe Phe Gln Asp Asp Trp Arg Ala Arg      50 55 60 Pro Ser Gly Ala Arg Pro Trp Pro Ile Val Leu Ile His Gly Ser Gly  65 70 75 80 Ala Ser Lys Gly Ser Trp Glu Glu Met Gly Ala Glu Leu Arg Ser Lys                  85 90 95 Gly Trp Ala Val Phe Ala Pro Asp Phe Gly Thr Arg Ala Thr Glu Pro             100 105 110 Ile Ala Ala Ser Ala Ala Gln Ile Gly Ala Tyr Ile Asp Ala Val Leu         115 120 125 Leu Val Thr Gly Ala Ala Gln Ile Val Leu Val Gly His Ser Gln Gly     130 135 140 Gly Val Val Ala Arg Tyr Trp Met Arg Thr Tyr Gly Gly Tyr Met Lys 145 150 155 160 Val Arg His Met Ile Ser Ile Ser Thr Pro Asn His Gly Thr Leu Met                 165 170 175 Gly Gly Ile Leu Asn Pro Met Thr Lys Val Lys Ser Gly Glu Gly Thr             180 185 190 Ile Glu Lys Leu Met His Arg Leu Phe Gly Pro Thr Gly Phe Glu Gln         195 200 205 Leu Arg Gly His Asp Ile Ile Glu Phe Leu Ala Asp Gly Gly Asp Leu     210 215 220 Asp Pro Gly Val Thr Tyr Thr Cys Ile Gly Thr His Phe Asp Pro Phe 225 230 235 240 Ile Gln Pro Pro Glu Val Ala Phe Leu Glu Val Asn Glu Asp Asp Asp                 245 250 255 Pro Asn Arg Val His Asn Ile Trp Val Glu Asp Glu His Pro Arg Ala             260 265 270 Met Ile Ala His Asn Asp Met Val Arg Asp Pro Arg Val Ile Glu Ile         275 280 285 Val Arg Ala Glu Leu Asp Arg Val Ala Arg Leu Gly     290 295 300 <210> 199 <211> 1095 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (1072) <223> RXA02269 <400> 199 cgcaatgatt gcccacaacg atatggtgcg cgatcccagg gtgatcgaaa tcgtacgcgc 60 agagctcgac cgggtggcac gcctcggcta agttggggac atg gtt gac gcc ctc 115                                             Met val asp ala leu                                               1 5 aat gat ctc cgc cga gaa ctc aca aac gcg tta agg tcc gtg tgg aaa 163 Asn Asp Leu Arg Arg Glu Leu Thr Asn Ala Leu Arg Ser Val Trp Lys                  10 15 20 aac ctc ccc act gat aac gcc ccg cag gcc gat gcc ttg cca gac gat 211 Asn Leu Pro Thr Asp Asn Ala Pro Gln Ala Asp Ala Leu Pro Asp Asp              25 30 35 gta gtg gaa gag att gcg ata aat ttc tac cgt gat ccc aaa aac cgc 259 Val Val Glu Glu Ile Ala Ile Asn Phe Tyr Arg Asp Pro Lys Asn Arg          40 45 50 ggc aaa ctc aac gaa gac aaa aca gat tcc ttg ccg atg ctc gcg cgc 307 Gly Lys Leu Asn Glu Asp Lys Thr Asp Ser Leu Pro Met Leu Ala Arg      55 60 65 ata cgt tca cgt gga ctt ttt gaa gac gat tgg cgc gcc cgc ccc acc 355 Ile Arg Ser Arg Gly Leu Phe Glu Asp Asp Trp Arg Ala Arg Pro Thr  70 75 80 85 gaa gac cgc ccc tgg cca gtg gta tta gtc cac gga act gga tca aca 403 Glu Asp Arg Pro Trp Pro Val Val Leu Val His Gly Thr Gly Ser Thr                  90 95 100 aaa ggt gat tgg caa gac ttg gga gcc gat cta cgc cgc gac ggc tgg 451 Lys Gly Asp Trp Gln Asp Leu Gly Ala Asp Leu Arg Arg Asp Gly Trp             105 110 115 gca gtg ttt gca ccc gaa ttt ggc caa cgc gcc acc ggt tca gtc gca 499 Ala Val Phe Ala Pro Glu Phe Gly Gln Arg Ala Thr Gly Ser Val Ala         120 125 130 gaa tca tcc gca caa att ggc gcc tat ata gat aca gta ttg ctt gct 547 Glu Ser Ser Ala Gln Ile Gly Ala Tyr Ile Asp Thr Val Leu Leu Ala     135 140 145 aca gga gcc tca aaa gtc att gtc gtt ggc cac tcc caa ggc ggc gtg 595 Thr Gly Ala Ser Lys Val Ile Val Val Gly His Ser Gln Gly Gly Val 150 155 160 165 ttg ctg aga tac tgg atg cgt gtt ttg ggt ggt gca tcc aaa gtc aaa 643 Leu Leu Arg Tyr Trp Met Arg Val Leu Gly Gly Ala Ser Lys Val Lys                 170 175 180 cac atg gtc tcc ctc gct gtc ccc aat cac ggc acc acc atg ggc gga 691 His Met Val Ser Leu Ala Val Pro Asn His Gly Thr Thr Met Gly Gly             185 190 195 atc gtc agc ccg cta atc cgt aac aat cgt ggc gaa agt gtg gtt aat 739 Ile Val Ser Pro Leu Ile Arg Asn Asn Arg Gly Glu Ser Val Val Asn         200 205 210 tct gtc gtt caa tca tgg ttc ggc gaa gct gga ttt gaa atg atc cgc 787 Ser Val Val Gln Ser Trp Phe Gly Glu Ala Gly Phe Glu Met Ile Arg     215 220 225 gga cac gac acc atc aac gcc atc aat gaa ggc ggc gat ttg gat cca 835 Gly His Asp Thr Ile Asn Ala Ile Asn Glu Gly Gly Asp Leu Asp Pro 230 235 240 245 gac gtg aca tat ctg tgc atc gcc acc cac ttt gac acc gtg att cag 883 Asp Val Thr Tyr Leu Cys Ile Ala Thr His Phe Asp Thr Val Ile Gln                 250 255 260 ccc cct gaa acc tgc ttc cta gag gcc cgg aac ccc gaa gaa ctc aag 931 Pro Pro Glu Thr Cys Phe Leu Glu Ala Arg Asn Pro Glu Glu Leu Lys             265 270 275 cgg gtc caa aac atc tgg gtg gaa aac ctc gac ccc aat tca gtc gtg 979 Arg Val Gln Asn Ile Trp Val Glu Asn Leu Asp Pro Asn Ser Val Val         280 285 290 ctc cac gaa gca atg cct tac gat ccc cgc gta cgc gca ctg gtc agg 1027 Leu His Glu Ala Met Pro Tyr Asp Pro Arg Val Arg Ala Leu Val Arg     295 300 305 gcg gat ttg agc aaa ttg gtg gag att tcc gag act gcg gag aac 1072 Ala Asp Leu Ser Lys Leu Val Glu Ile Ser Glu Thr Ala Glu Asn 310 315 320 taggggtttt ggtggttgtc taa 1095 <210> 200 <211> 324 <212> PRT <213> Corynebacterium glutamicum <400> 200 Met Val Asp Ala Leu Asn Asp Leu Arg Arg Glu Leu Thr Asn Ala Leu   1 5 10 15 Arg Ser Val Trp Lys Asn Leu Pro Thr Asp Asn Ala Pro Gln Ala Asp              20 25 30 Ala Leu Pro Asp Asp Val Val Glu Glu Ile Ala Ile Asn Phe Tyr Arg          35 40 45 Asp Pro Lys Asn Arg Gly Lys Leu Asn Glu Asp Lys Thr Asp Ser Leu      50 55 60 Pro Met Leu Ala Arg Ile Arg Ser Arg Gly Leu Phe Glu Asp Asp Trp  65 70 75 80 Arg Ala Arg Pro Thr Glu Asp Arg Pro Trp Pro Val Val Leu Val His                  85 90 95 Gly Thr Gly Ser Thr Lys Gly Asp Trp Gln Asp Leu Gly Ala Asp Leu             100 105 110 Arg Arg Asp Gly Trp Ala Val Phe Ala Pro Glu Phe Gly Gln Arg Ala         115 120 125 Thr Gly Ser Val Ala Glu Ser Ser Ala Gln Ile Gly Ala Tyr Ile Asp     130 135 140 Thr Val Leu Leu Ala Thr Gly Ala Ser Lys Val Ile Val Val Gly His 145 150 155 160 Ser Gln Gly Gly Val Leu Leu Arg Tyr Trp Met Arg Val Leu Gly Gly                 165 170 175 Ala Ser Lys Val Lys His Met Val Ser Leu Ala Val Pro Asn His Gly             180 185 190 Thr Thr Met Gly Gly Ile Val Ser Pro Leu Ile Arg Asn Asn Arg Gly         195 200 205 Glu Ser Val Val Asn Ser Val Val Gln Ser Trp Phe Gly Glu Ala Gly     210 215 220 Phe Glu Met Ile Arg Gly His Asp Thr Ile Asn Ala Ile Asn Glu Gly 225 230 235 240 Gly Asp Leu Asp Pro Asp Val Thr Tyr Leu Cys Ile Ala Thr His Phe                 245 250 255 Asp Thr Val Ile Gln Pro Pro Glu Thr Cys Phe Leu Glu Ala Arg Asn             260 265 270 Pro Glu Glu Leu Lys Arg Val Gln Asn Ile Trp Val Glu Asn Leu Asp         275 280 285 Pro Asn Ser Val Val Leu His Glu Ala Met Pro Tyr Asp Pro Arg Val     290 295 300 Arg Ala Leu Val Arg Ala Asp Leu Ser Lys Leu Val Glu Ile Ser Glu 305 310 315 320 Thr Ala Glu Asn <210> 201 <211> 1146 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1123) <223> RXA01614 <400> 201 tgcaattcgc aaacatgagt agtatcgcgg aagtttcacc acgtgaacat ttcagtcgac 60 tcgcgcacac cacaccaaca atcgacctat cgttatacgt atg aat cag atg cag 115                                             Met Asn Gln Met Gln                                               1 5 cag tgg aaa cca gac ttc ctg gga gag ggc tac caa aac ctc acc atc 163 Gln Trp Lys Pro Asp Phe Leu Gly Glu Gly Tyr Gln Asn Leu Thr Ile                  10 15 20 gag ctc ggc gac gac ccg gat aat gaa aca gat gtt gtg aca acg gtt 211 Glu Leu Gly Asp Asp Pro Asp Asn Glu Thr Asp Val Val Thr Thr Val              25 30 35 gtg cgc tac aac cca gac aat cac gcg gac gag tct ttt gct gcc cgc 259 Val Arg Tyr Asn Pro Asp Asn His Ala Asp Glu Ser Phe Ala Ala Arg          40 45 50 cca gcg ttg ctg tgg gtt cac ggc atg acg gac tac ttc ttc cac act 307 Pro Ala Leu Leu Trp Val His Gly Met Thr Asp Tyr Phe Phe His Thr      55 60 65 gaa ttc gcg gag ttt ttc cac aat gcc ggt ttt gct gtg tac ggc att 355 Glu Phe Ala Glu Phe Phe His Asn Ala Gly Phe Ala Val Tyr Gly Ile  70 75 80 85 gat ctt aga aaa tgt gga cgc tcc tac cgt cca gga cag cag tgg cac 403 Asp Leu Arg Lys Cys Gly Arg Ser Tyr Arg Pro Gly Gln Gln Trp His                  90 95 100 tac acc tct gat ctt gcc cat tac ttc cct gac tta aca gct gct gcc 451 Tyr Thr Ser Asp Leu Ala His Tyr Phe Pro Asp Leu Thr Ala Ala Ala             105 110 115 gag gtc atc tct tcc acc cac cct gag cta gtc ccc gtc gcc cat tcc 499 Glu Val Ile Ser Ser Thr His Pro Glu Leu Val Pro Val Ala His Ser         120 125 130 act ggt gga ctc atc gtt cct ctg tgg atg tcc cag atg cgc aca agc 547 Thr Gly Gly Leu Ile Val Pro Leu Trp Met Ser Gln Met Arg Thr Ser     135 140 145 aat cca gct gcc att gag aag att cca gcg ctg gtc ctc aac agt ccg 595 Asn Pro Ala Ala Ile Glu Lys Ile Pro Ala Leu Val Leu Asn Ser Pro 150 155 160 165 tgg ctg gac atg atg tat cca cca ctg ttc atc aag ctg atc acc cct 643 Trp Leu Asp Met Met Tyr Pro Pro Leu Phe Ile Lys Leu Ile Thr Pro                 170 175 180 atg gtg agg gtg ttg ggc aaa cgc tcc ccc aca acc atc atc cca ggc 691 Met Val Arg Val Leu Gly Lys Arg Ser Pro Thr Thr Ile Ile Pro Gly             185 190 195 gga ggt ttg gga gca tac gga aaa tcg atc cat aag aac ttt tac ggc 739 Gly Gly Leu Gly Ala Tyr Gly Lys Ser Ile His Lys Asn Phe Tyr Gly         200 205 210 gaa tgg gac ttt gac acc acc atc aag cct gta gaa gga cat aaa aag 787 Glu Trp Asp Phe Asp Thr Thr Ile Lys Pro Val Glu Gly His Lys Lys     215 220 225 agc atc gga tgg ctt cgg gca gtc atg gct ggc caa gca gaa atc cat 835 Ser Ile Gly Trp Leu Arg Ala Val Met Ala Gly Gln Ala Glu Ile His 230 235 240 245 cac gac cac gtg aat gtc gga gtg gac gtg ctc acg ctg tgt tca aat 883 His Asp His Val Asn Val Gly Val Asp Val Leu Thr Leu Cys Ser Asn                 250 255 260 aag tcc tgg ttg aag tct gaa tac aca gag gac acc aac act tca gac 931 Lys Ser Trp Leu Lys Ser Glu Tyr Thr Glu Asp Thr Asn Thr Ser Asp             265 270 275 gcg gtt ttg gat gtg aaa cac att caa aag tgg gct cct cat ttg agc 979 Ala Val Leu Asp Val Lys His Ile Gln Lys Trp Ala Pro His Leu Ser         280 285 290 tcg cca tcg tcc agg gtt gat gtt gag atc atc gac aac gct cgc cac 1027 Ser Pro Ser Ser Arg Val Asp Val Glu Ile Ile Asp Asn Ala Arg His     295 300 305 gat att ttc ctc tca agg aaa ccc gcc aga gat cac gcc tct gaa gta 1075 Asp Ile Phe Leu Ser Arg Lys Pro Ala Arg Asp His Ala Ser Glu Val 310 315 320 325 ctc aac aac tgg ctg caa tcg aag ctt tcc agc ctc aaa cca tct caa 1123 Leu Asn Asn Trp Leu Gln Ser Lys Leu Ser Ser Leu Lys Pro Ser Gln                 330 335 340 taacaccgcg aattatagac tga 1146 <210> 202 <211> 341 <212> PRT <213> Corynebacterium glutamicum <400> 202 Met Asn Gln Met Gln Gln Trp Lys Pro Asp Phe Leu Gly Glu Gly Tyr   1 5 10 15 Gln Asn Leu Thr Ile Glu Leu Gly Asp Asp Pro Asp Asn Glu Thr Asp              20 25 30 Val Val Thr Thr Val Val Arg Tyr Asn Pro Asp Asn His Ala Asp Glu          35 40 45 Ser Phe Ala Ala Arg Pro Ala Leu Leu Trp Val His Gly Met Thr Asp      50 55 60 Tyr Phe Phe His Thr Glu Phe Ala Glu Phe Phe His Asn Ala Gly Phe  65 70 75 80 Ala Val Tyr Gly Ile Asp Leu Arg Lys Cys Gly Arg Ser Tyr Arg Pro                  85 90 95 Gly Gln Gln Trp His Tyr Thr Ser Asp Leu Ala His Tyr Phe Pro Asp             100 105 110 Leu Thr Ala Ala Ala Glu Val Ile Ser Ser Thr His Pro Glu Leu Val         115 120 125 Pro Val Ala His Ser Thr Gly Gly Leu Ile Val Pro Leu Trp Met Ser     130 135 140 Gln Met Arg Thr Ser Asn Pro Ala Ala Ile Glu Lys Ile Pro Ala Leu 145 150 155 160 Val Leu Asn Ser Pro Trp Leu Asp Met Met Tyr Pro Pro Leu Phe Ile                 165 170 175 Lys Leu Ile Thr Pro Met Val Arg Val Leu Gly Lys Arg Ser Pro Thr             180 185 190 Thr Ile Ile Pro Gly Gly Gly Leu Gly Ala Tyr Gly Lys Ser Ile His         195 200 205 Lys Asn Phe Tyr Gly Glu Trp Asp Phe Asp Thr Thr Ile Lys Pro Val     210 215 220 Glu Gly His Lys Lys Ser Ile Gly Trp Leu Arg Ala Val Met Ala Gly 225 230 235 240 Gln Ala Glu Ile His His Asp His Val Asn Val Gly Val Asp Val Leu                 245 250 255 Thr Leu Cys Ser Asn Lys Ser Trp Leu Lys Ser Glu Tyr Thr Glu Asp             260 265 270 Thr Asn Thr Ser Asp Ala Val Leu Asp Val Lys His Ile Gln Lys Trp         275 280 285 Ala Pro His Leu Ser Ser Pro Ser Ser Arg Val Asp Val Glu Ile Ile     290 295 300 Asp Asn Ala Arg His Asp Ile Phe Leu Ser Arg Lys Pro Ala Arg Asp 305 310 315 320 His Ala Ser Glu Val Leu Asn Asn Trp Leu Gln Ser Lys Leu Ser Ser                 325 330 335 Leu Lys Pro Ser Gln             340 <210> 203 <211> 630 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (101) .. (607) <223> RXA01983 <400> 203 atatcgctgc catggcagcc ttgctgggca acctcaagca cactgaccta gaagagctcc 60 ccaccgatta ccaggggtgt cctcccatgt ccgctgcgtt atg gaa ggc tac gga 115                                             Met Glu Gly Tyr Gly                                               1 5 cct acc cag atc gaa aag ctc tta cct gca tac aca cag gtc aac aca 163 Pro Thr Gln Ile Glu Lys Leu Leu Pro Ala Tyr Thr Gln Val Asn Thr                  10 15 20 gcc ggg aat aat cca gcg acg acg cct gag caa gat ctc ctc ggc gga 211 Ala Gly Asn Asn Pro Ala Thr Thr Pro Glu Gln Asp Leu Leu Gly Gly              25 30 35 gct gca acc tcg ccg gaa aac tac gac cac cag ctg cag tac gca gtc 259 Ala Ala Thr Ser Pro Glu Asn Tyr Asp His Gln Leu Gln Tyr Ala Val          40 45 50 gac gcc agt ccg gtg cat cag aat gcg gca cag gca ccg ccc ttc ctg 307 Asp Ala Ser Pro Val His Gln Asn Ala Ala Gln Ala Pro Pro Phe Leu      55 60 65 atc atg cac ggc act ggt gac cgg atg gtc cct ccg gag caa tcg gct 355 Ile Met His Gly Thr Gly Asp Arg Met Val Pro Pro Glu Gln Ser Ala  70 75 80 85 gcg ctg cac acc cat ctt gtg cag gct ggt cgg cag tcc acc ctg gta 403 Ala Leu His Thr His Leu Val Gln Ala Gly Arg Gln Ser Thr Leu Val                  90 95 100 ctc att gag ggc ttt ggc cac ggt ttc ctc aat ccc ggg gaa gtc gcg 451 Leu Ile Glu Gly Phe Gly His Gly Phe Leu Asn Pro Gly Glu Val Ala             105 110 115 gag ctg ggg cca aac gtt cga cta gac aat ggt cgg ctc gag cgg gag 499 Glu Leu Gly Pro Asn Val Arg Leu Asp Asn Gly Arg Leu Glu Arg Glu         120 125 130 cct cag aca aat ttc agc gcg cag cag agt ccg gga aac ccc ttt gaa 547 Pro Gln Thr Asn Phe Ser Ala Gln Gln Ser Pro Gly Asn Pro Phe Glu     135 140 145 cta cag gga ctt gcc gcc gac cat gag atg atc aag cgc ttt ttc acc 595 Leu Gln Gly Leu Ala Ala Asp His Glu Met Ile Lys Arg Phe Phe Thr 150 155 160 165 ctg cac ctt cgc taagactcta ccttcaccca act 630 Leu His Leu Arg <210> 204 <211> 169 <212> PRT <213> Corynebacterium glutamicum <400> 204 Met Glu Gly Tyr Gly Pro Thr Gln Ile Glu Lys Leu Leu Pro Ala Tyr   1 5 10 15 Thr Gln Val Asn Thr Ala Gly Asn Asn Pro Ala Thr Thr Pro Glu Gln              20 25 30 Asp Leu Leu Gly Gly Ala Ala Thr Ser Pro Glu Asn Tyr Asp His Gln          35 40 45 Leu Gln Tyr Ala Val Asp Ala Ser Pro Val His Gln Asn Ala Ala Gln      50 55 60 Ala Pro Pro Phe Leu Ile Met His Gly Thr Gly Asp Arg Met Val Pro  65 70 75 80 Pro Glu Gln Ser Ala Ala Leu His Thr His Leu Val Gln Ala Gly Arg                  85 90 95 Gln Ser Thr Leu Val Leu Ile Glu Gly Phe Gly His Gly Phe Leu Asn             100 105 110 Pro Gly Glu Val Ala Glu Leu Gly Pro Asn Val Arg Leu Asp Asn Gly         115 120 125 Arg Leu Glu Arg Glu Pro Gln Thr Asn Phe Ser Ala Gln Gln Ser Pro     130 135 140 Gly Asn Pro Phe Glu Leu Gln Gly Leu Ala Ala Asp His Glu Met Ile 145 150 155 160 Lys Arg Phe Phe Thr Leu His Leu Arg                 165 <210> 205 <211> 1414 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (1414) <223> RXN02947 <400> 205 gtatgttcac acaagaaccc tgcacaacgc cttcaaagta cgtcgaccac gaccaagcgc 60 attattcact ctcacccttc aggatttaga ctaagaaacc atg act gca gca cag 115                                             Met thr ala ala gln                                               1 5 acc aaa cct gac ctc acc acc acg gct gga aag ctg tcc gat ctt cgc 163 Thr Lys Pro Asp Leu Thr Thr Thr Ala Gly Lys Leu Ser Asp Leu Arg                  10 15 20 tcc cgt ctt gca gaa gct caa gct cca atg ggc gaa gca act gta gaa 211 Ser Arg Leu Ala Glu Ala Gln Ala Pro Met Gly Glu Ala Thr Val Glu              25 30 35 aaa gtg cac gct gct ggc agg aag act gcc cgc gaa cgt atc gag tat 259 Lys Val His Ala Ala Gly Arg Lys Thr Ala Arg Glu Arg Ile Glu Tyr          40 45 50 ttg ctc gat gag ggc tct ttc gta gag atc gat gct ctt gct cgt cac 307 Leu Leu Asp Glu Gly Ser Phe Val Glu Ile Asp Ala Leu Ala Arg His      55 60 65 cgt tcc aag aac ttc ggc ctg gat gcc aag cgt cca gtt act gac ggt 355 Arg Ser Lys Asn Phe Gly Leu Asp Ala Lys Arg Pro Val Thr Asp Gly  70 75 80 85 gtt gtg act ggt tac ggc acc atc gat ggc cgt aag gtc tgt gtg ttc 403 Val Val Thr Gly Tyr Gly Thr Ile Asp Gly Arg Lys Val Cys Val Phe                  90 95 100 tcc cag gac ggc gct gta ttc ggt ggc gct ttg ggt gaa gtt tat ggt 451 Ser Gln Asp Gly Ala Val Phe Gly Gly Ala Leu Gly Glu Val Tyr Gly             105 110 115 gaa aag atc gtt aag gtt atg gat ctt gcg atc aag acc ggt gtg cct 499 Glu Lys Ile Val Lys Val Met Asp Leu Ala Ile Lys Thr Gly Val Pro         120 125 130 ttg atc gga atc aat gag ggt gct ggt gcg cgt atc cag gaa ggt gtt 547 Leu Ile Gly Ile Asn Glu Gly Ala Gly Ala Arg Ile Gln Glu Gly Val     135 140 145 gtg tct ctg ggt ctg tac tca cag atc ttc tac cgc aac acc cag gcg 595 Val Ser Leu Gly Leu Tyr Ser Gln Ile Phe Tyr Arg Asn Thr Gln Ala 150 155 160 165 tct ggc gtt atc cca cag atc tct ttg atc atg ggt gcc tgc gct ggt 643 Ser Gly Val Ile Pro Gln Ile Ser Leu Ile Met Gly Ala Cys Ala Gly                 170 175 180 ggt cac gtg tac tcc cct gct ctg act gac ttc atc gtc atg gtg gat 691 Gly His Val Tyr Ser Pro Ala Leu Thr Asp Phe Ile Val Met Val Asp             185 190 195 cag act tcc aag atg ttt atc acc ggc cct gat gtc atc aag act gtc 739 Gln Thr Ser Lys Met Phe Ile Thr Gly Pro Asp Val Ile Lys Thr Val         200 205 210 acc ggt gaa gat gtc acc cag gag gag ctc ggt ggc gct cac acc cac 787 Thr Gly Glu Asp Val Thr Gln Glu Glu Leu Gly Gly Ala His Thr His     215 220 225 atg gct acc tcc ggt acc tcc cat tac tct gct tct gat gat tca gat 835 Met Ala Thr Ser Gly Thr Ser His Tyr Ser Ala Ser Asp Asp Ser Asp 230 235 240 245 gct ttg gat tgg gtt cgc gag ctg acc tct tat ctt cca tcc aac aac 883 Ala Leu Asp Trp Val Arg Glu Leu Thr Ser Tyr Leu Pro Ser Asn Asn                 250 255 260 cgt gcg gaa act cct cgc cag gag gcc gac atc atg atc ggt tcc atc 931 Arg Ala Glu Thr Pro Arg Gln Glu Ala Asp Ile Met Ile Gly Ser Ile             265 270 275 cag gaa aac atc aac gat gtg gat ctg gaa ttg gac acc atc atc ccg 979 Gln Glu Asn Ile Asn Asp Val Asp Leu Glu Leu Asp Thr Ile Ile Pro         280 285 290 gat tcc ccg aac cag cct tat gac atg aag gaa gtt att tcc cgc atc 1027 Asp Ser Pro Asn Gln Pro Tyr Asp Met Lys Glu Val Ile Ser Arg Ile     295 300 305 gtc gac gac gcc gag ttc ttc gag atc cag gaa gac tac gca gag aac 1075 Val Asp Asp Ala Glu Phe Phe Glu Ile Gln Glu Asp Tyr Ala Glu Asn 310 315 320 325 atc ctg tgt ggc ttc gct cgc gtt gag gtc cgt tct gtt ggc atc gtg 1123 Ile Leu Cys Gly Phe Ala Arg Val Glu Val Arg Ser Val Gly Ile Val                 330 335 340 gct aac cag cca acc cag ttc gct ggc tgc ttg gat att aag gca tct 1171 Ala Asn Gln Pro Thr Gln Phe Ala Gly Cys Leu Asp Ile Lys Ala Ser             345 350 355 gag aag gct gcc cgt ttc atc cgc acc tgc gat gcc ttc aac atc cca 1219 Glu Lys Ala Ala Arg Phe Ile Arg Thr Cys Asp Ala Phe Asn Ile Pro         360 365 370 atc ctt gag ttc gtg gac gtt cca ggc ttc ctg cct ggc acc aac cag 1267 Ile Leu Glu Phe Val Asp Val Pro Gly Phe Leu Pro Gly Thr Asn Gln     375 380 385 gaa ttc gac ggc atc atc cgc cgc ggc gca aag ctg ctt tac gct tac 1315 Glu Phe Asp Gly Ile Ile Arg Arg Gly Ala Lys Leu Leu Tyr Ala Tyr 390 395 400 405 gct gaa gca acc gtc ggc aag atc acc gtc atc acc cgc aag tcc tac 1363 Ala Glu Ala Thr Val Gly Lys Ile Thr Val Ile Thr Arg Lys Ser Tyr                 410 415 420 ggc gga gcg tac tgc gtg atg ggt tcc aag gat atg ggc gct ggc ctg 1411 Gly Gly Ala Tyr Cys Val Met Gly Ser Lys Asp Met Gly Ala Gly Leu             425 430 435 gta 1414 Val <206> 206 <211> 438 <212> PRT <213> Corynebacterium glutamicum <400> 206 Met Thr Ala Ala Gln Thr Lys Pro Asp Leu Thr Thr Thr Ala Gly Lys   1 5 10 15 Leu Ser Asp Leu Arg Ser Arg Leu Ala Glu Ala Gln Ala Pro Met Gly              20 25 30 Glu Ala Thr Val Glu Lys Val His Ala Ala Gly Arg Lys Thr Ala Arg          35 40 45 Glu Arg Ile Glu Tyr Leu Leu Asp Glu Gly Ser Phe Val Glu Ile Asp      50 55 60 Ala Leu Ala Arg His Arg Ser Lys Asn Phe Gly Leu Asp Ala Lys Arg  65 70 75 80 Pro Val Thr Asp Gly Val Val Thr Gly Tyr Gly Thr Ile Asp Gly Arg                  85 90 95 Lys Val Cys Val Phe Ser Gln Asp Gly Ala Val Phe Gly Gly Ala Leu             100 105 110 Gly Glu Val Tyr Gly Glu Lys Ile Val Lys Val Met Asp Leu Ala Ile         115 120 125 Lys Thr Gly Val Pro Leu Ile Gly Ile Asn Glu Gly Ala Gly Ala Arg     130 135 140 Ile Gln Glu Gly Val Val Ser Leu Gly Leu Tyr Ser Gln Ile Phe Tyr 145 150 155 160 Arg Asn Thr Gln Ala Ser Gly Val Ile Pro Gln Ile Ser Leu Ile Met                 165 170 175 Gly Ala Cys Ala Gly Gly His Val Tyr Ser Pro Ala Leu Thr Asp Phe             180 185 190 Ile Val Met Val Asp Gln Thr Ser Lys Met Phe Ile Thr Gly Pro Asp         195 200 205 Val Ile Lys Thr Val Thr Gly Glu Asp Val Thr Gln Glu Glu Leu Gly     210 215 220 Gly Ala His Thr His Met Ala Thr Ser Gly Thr Ser His Tyr Ser Ala 225 230 235 240 Ser Asp Asp Ser Asp Ala Leu Asp Trp Val Arg Glu Leu Thr Ser Tyr                 245 250 255 Leu Pro Ser Asn Asn Arg Ala Glu Thr Pro Arg Gln Glu Ala Asp Ile             260 265 270 Met Ile Gly Ser Ile Gln Glu Asn Ile Asn Asp Val Asp Leu Glu Leu         275 280 285 Asp Thr Ile Ile Pro Asp Ser Pro Asn Gln Pro Tyr Asp Met Lys Glu     290 295 300 Val Ile Ser Arg Ile Val Asp Asp Ala Glu Phe Phe Glu Ile Gln Glu 305 310 315 320 Asp Tyr Ala Glu Asn Ile Leu Cys Gly Phe Ala Arg Val Glu Val Arg                 325 330 335 Ser Val Gly Ile Val Ala Asn Gln Pro Thr Gln Phe Ala Gly Cys Leu             340 345 350 Asp Ile Lys Ala Ser Glu Lys Ala Ala Arg Phe Ile Arg Thr Cys Asp         355 360 365 Ala Phe Asn Ile Pro Ile Leu Glu Phe Val Asp Val Pro Gly Phe Leu     370 375 380 Pro Gly Thr Asn Gln Glu Phe Asp Gly Ile Ile Arg Arg Gly Ala Lys 385 390 395 400 Leu Leu Tyr Ala Tyr Ala Glu Ala Thr Val Gly Lys Ile Thr Val Ile                 405 410 415 Thr Arg Lys Ser Tyr Gly Gly Ala Tyr Cys Val Met Gly Ser Lys Asp             420 425 430 Met Gly Ala Gly Leu Val         435 <210> 207 <211> 688 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (101) .. (688) <223> FRXA02320 <400> 207 gtatgttcac acaagaaccc tgcacaacgc cttcaaagta cgtcgaccac gaccaagcgc 60 attattcact ctcacccttc aggatttaga ctaagaaacc atg act gca gca cag 115                                             Met thr ala ala gln                                               1 5 acc aaa cct gac ctc acc acc acg gct gga aag ctg tcc gat ctt cgc 163 Thr Lys Pro Asp Leu Thr Thr Thr Ala Gly Lys Leu Ser Asp Leu Arg                  10 15 20 tcc cgt ctt gca gaa gct caa gct cca atg ggc gaa gca act gta gaa 211 Ser Arg Leu Ala Glu Ala Gln Ala Pro Met Gly Glu Ala Thr Val Glu              25 30 35 aaa gtg cac gct gct ggc agg aag act gcc cgc gaa cgt atc gag tat 259 Lys Val His Ala Ala Gly Arg Lys Thr Ala Arg Glu Arg Ile Glu Tyr          40 45 50 ttg ctc gat gag ggc tct ttc gta gag atc gat gct ctt gct cgt cac 307 Leu Leu Asp Glu Gly Ser Phe Val Glu Ile Asp Ala Leu Ala Arg His      55 60 65 cgt tcc aag aac ttc ggc ctg gat gcc aag cgt cca gtt act gac ggt 355 Arg Ser Lys Asn Phe Gly Leu Asp Ala Lys Arg Pro Val Thr Asp Gly  70 75 80 85 gtt gtg act ggt tac ggc acc atc gat ggc cgt aag gtc tgt gtg ttc 403 Val Val Thr Gly Tyr Gly Thr Ile Asp Gly Arg Lys Val Cys Val Phe                  90 95 100 tcc cag gac ggc gct gta ttc ggt ggc gct ttg ggt gaa gtt tat ggt 451 Ser Gln Asp Gly Ala Val Phe Gly Gly Ala Leu Gly Glu Val Tyr Gly             105 110 115 gaa aag atc gtt aag gtt atg gat ctt gcg atc aag acc ggt gtg cct 499 Glu Lys Ile Val Lys Val Met Asp Leu Ala Ile Lys Thr Gly Val Pro         120 125 130 ttg atc gga atc aat gag ggt gct ggt gcg cgt atc cag gaa ggt gtt 547 Leu Ile Gly Ile Asn Glu Gly Ala Gly Ala Arg Ile Gln Glu Gly Val     135 140 145 gtg tct ctg ggt ctg tac tca cag atc ttc tac cgc aac acc cag gcg 595 Val Ser Leu Gly Leu Tyr Ser Gln Ile Phe Tyr Arg Asn Thr Gln Ala 150 155 160 165 tct ggc gtt atc cca cag atc tct ttg atc atg ggt gcc tgc gct ggt 643 Ser Gly Val Ile Pro Gln Ile Ser Leu Ile Met Gly Ala Cys Ala Gly                 170 175 180 ggt cac gtg tac tcc cct gct ctg act gac ttc atc gtc atg gtg 688 Gly His Val Tyr Ser Pro Ala Leu Thr Asp Phe Ile Val Met Val             185 190 195 <210> 208 <211> 196 <212> PRT <213> Corynebacterium glutamicum <400> 208 Met Thr Ala Ala Gln Thr Lys Pro Asp Leu Thr Thr Thr Ala Gly Lys   1 5 10 15 Leu Ser Asp Leu Arg Ser Arg Leu Ala Glu Ala Gln Ala Pro Met Gly              20 25 30 Glu Ala Thr Val Glu Lys Val His Ala Ala Gly Arg Lys Thr Ala Arg          35 40 45 Glu Arg Ile Glu Tyr Leu Leu Asp Glu Gly Ser Phe Val Glu Ile Asp      50 55 60 Ala Leu Ala Arg His Arg Ser Lys Asn Phe Gly Leu Asp Ala Lys Arg  65 70 75 80 Pro Val Thr Asp Gly Val Val Thr Gly Tyr Gly Thr Ile Asp Gly Arg                  85 90 95 Lys Val Cys Val Phe Ser Gln Asp Gly Ala Val Phe Gly Gly Ala Leu             100 105 110 Gly Glu Val Tyr Gly Glu Lys Ile Val Lys Val Met Asp Leu Ala Ile         115 120 125 Lys Thr Gly Val Pro Leu Ile Gly Ile Asn Glu Gly Ala Gly Ala Arg     130 135 140 Ile Gln Glu Gly Val Val Ser Leu Gly Leu Tyr Ser Gln Ile Phe Tyr 145 150 155 160 Arg Asn Thr Gln Ala Ser Gly Val Ile Pro Gln Ile Ser Leu Ile Met                 165 170 175 Gly Ala Cys Ala Gly Gly His Val Tyr Ser Pro Ala Leu Thr Asp Phe             180 185 190 Ile Val Met Val         195 <210> 209 <211> 519 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (519) <223> FRXA02851 <220> <221> misc_feature <222> 135 <223> n indicates any nucleotide <220> <221> misc_feature <222> 209 <223> n indicates any nucleotide <220> <221> misc_feature <222> 215 <223> n indicates any nucleotide <220> <221> misc_feature <222> 258 <223> n indicates any nucleotide <220> <221> VARIANT <222> 70 <223> Xaa = Val, Ala, Asp, or Gly <220> <221> VARIANT <222> 72 <223> Xaa = Phe or Leu <220> <221> VARIANT <222> 86 <223> Xaa = Cys, Trp, or stop codon <400> 209 cct cgc cag aag gcc gac atc atg atc ggt tcc atc cag gaa aac atc 48 Pro Arg Gln Lys Ala Asp Ile Met Ile Gly Ser Ile Gln Glu Asn Ile   1 5 10 15 aac gat gtg gat ctg gaa ttg gac acc atc atc ccg gat tcc ccg aac 96 Asn Asp Val Asp Leu Glu Leu Asp Thr Ile Ile Pro Asp Ser Pro Asn              20 25 30 cag cct tat gac atg aag gaa gtt att tcc cgc atc gtn gac gac gcc 144 Gln Pro Tyr Asp Met Lys Glu Val Ile Ser Arg Ile Val Asp Asp Ala          35 40 45 gag ttc ttc gag atc cag gaa gac tac gca gag aac atc ctg tgt ggc 192 Glu Phe Phe Glu Ile Gln Glu Asp Tyr Ala Glu Asn Ile Leu Cys Gly      50 55 60 ttc gct cgc gtt gag gnc cgt tnt gtt ggc atc gtg gct aac cag cca 240 Phe Ala Arg Val Glu Xaa Arg Xaa Val Gly Ile Val Ala Asn Gln Pro  65 70 75 80 acc cag ttc gct ggc tgn ttg gat att aag gca tct gag aag gct gcc 288 Thr Gln Phe Ala Gly Xaa Leu Asp Ile Lys Ala Ser Glu Lys Ala Ala                  85 90 95 cgt ttc atc cgc acc tgc gat gcc ttc aac atc cca atc ctt gag ttc 336 Arg Phe Ile Arg Thr Cys Asp Ala Phe Asn Ile Pro Ile Leu Glu Phe             100 105 110 gtg gac gtt cca ggc ttc ctg cct ggc acc aac cag gaa ttc gac ggc 384 Val Asp Val Pro Gly Phe Leu Pro Gly Thr Asn Gln Glu Phe Asp Gly         115 120 125 atc atc cgc cgc ggc gca aag ctg ctt tac gct tac gct gaa gca acc 432 Ile Ile Arg Arg Gly Ala Lys Leu Leu Tyr Ala Tyr Ala Glu Ala Thr     130 135 140 gtc ggc aag atc acc gtc atc acc cgc aag tcc tac ggc gga gcg tac 480 Val Gly Lys Ile Thr Val Ile Thr Arg Lys Ser Tyr Gly Gly Ala Tyr 145 150 155 160 tgc gtg atg ggt tcc aag gat atg ggc gct ggc ctg gta 519 Cys Val Met Gly Ser Lys Asp Met Gly Ala Gly Leu Val                 165 170 <210> 210 <211> 173 <212> PRT <213> Corynebacterium glutamicum <220> <221> VARIANT <222> 70 <223> Xaa = Val, Ala, Asp, or Gly <220> <221> VARIANT <222> 72 <223> Xaa = Phe or Leu <220> <221> VARIANT <222> 86 <223> Xaa = Cys, Trp, or stop codon <400> 210 Pro Arg Gln Lys Ala Asp Ile Met Ile Gly Ser Ile Gln Glu Asn Ile   1 5 10 15 Asn Asp Val Asp Leu Glu Leu Asp Thr Ile Ile Pro Asp Ser Pro Asn              20 25 30 Gln Pro Tyr Asp Met Lys Glu Val Ile Ser Arg Ile Val Asp Asp Ala          35 40 45 Glu Phe Phe Glu Ile Gln Glu Asp Tyr Ala Glu Asn Ile Leu Cys Gly      50 55 60 Phe Ala Arg Val Glu Xaa Arg Xaa Val Gly Ile Val Ala Asn Gln Pro  65 70 75 80 Thr Gln Phe Ala Gly Xaa Leu Asp Ile Lys Ala Ser Glu Lys Ala Ala                  85 90 95 Arg Phe Ile Arg Thr Cys Asp Ala Phe Asn Ile Pro Ile Leu Glu Phe             100 105 110 Val Asp Val Pro Gly Phe Leu Pro Gly Thr Asn Gln Glu Phe Asp Gly         115 120 125 Ile Ile Arg Arg Gly Ala Lys Leu Leu Tyr Ala Tyr Ala Glu Ala Thr     130 135 140 Val Gly Lys Ile Thr Val Ile Thr Arg Lys Ser Tyr Gly Gly Ala Tyr 145 150 155 160 Cys Val Met Gly Ser Lys Asp Met Gly Ala Gly Leu Val                 165 170 <210> 211 <211> 1752 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1729) <223> RXN02321 <400> 211 tttaaaaact acccgcacgc agcacgaacc tgttcagtga tgtaaatcac cgcggaaata 60 ttgtggacgt tacccccgcc taccgctacg atttcaaaac atg acc att tcc tca 115                                             Met Thr Ile Ser Ser                                               1 5 cct ttg att gac gtc gcc aac ctt cca gac atc aac acc act gcc ggc 163 Pro Leu Ile Asp Val Ala Asn Leu Pro Asp Ile Asn Thr Thr Ala Gly                  10 15 20 aag atc gcc gac ctt aag gct cgc cgc gcg gaa gcc cat ttc ccc atg 211 Lys Ile Ala Asp Leu Lys Ala Arg Arg Ala Glu Ala His Phe Pro Met              25 30 35 ggt gaa aag gca gta gag aag gtc cac gct gct gga cgc ctc act gcc 259 Gly Glu Lys Ala Val Glu Lys Val His Ala Ala Gly Arg Leu Thr Ala          40 45 50 cgt gag cgc ttg gat tac tta ctc gat gag ggc tcc ttc atc gag acc 307 Arg Glu Arg Leu Asp Tyr Leu Leu Asp Glu Gly Ser Phe Ile Glu Thr      55 60 65 gat cag ctg gct cgc cac cgc acc acc gct ttc tgc ctg ggc gct aag 355 Asp Gln Leu Ala Arg His Arg Thr Thr Ala Phe Cys Leu Gly Ala Lys  70 75 80 85 cgt cct gca acc gac ggt atc gtg acc ggc tgg ggc acc att gat gga 403 Arg Pro Ala Thr Asp Gly Ile Val Thr Gly Trp Gly Thr Ile Asp Gly                  90 95 100 cgc gaa gtc tgc atc ttc tcg cag gac ggc acc gta ttc ggt ggc gcg 451 Arg Glu Val Cys Ile Phe Ser Gln Asp Gly Thr Val Phe Gly Gly Ala             105 110 115 ctt ggt gag gtg tac ggc gaa aag atg atc aag atc atg gag ctg gca 499 Leu Gly Glu Val Tyr Gly Glu Lys Met Ile Lys Ile Met Glu Leu Ala         120 125 130 atc gac acc ggc cgc cca ttg atc ggt ctt tac gaa ggc gct ggc gct 547 Ile Asp Thr Gly Arg Pro Leu Ile Gly Leu Tyr Glu Gly Ala Gly Ala     135 140 145 cgt att cag gac ggc gct gtc tcc ctg gac ttc att tcc cag acc ttc 595 Arg Ile Gln Asp Gly Ala Val Ser Leu Asp Phe Ile Ser Gln Thr Phe 150 155 160 165 tac caa aac att cag gct tct ggc gtt atc cca cag atc tcc gtc atc 643 Tyr Gln Asn Ile Gln Ala Ser Gly Val Ile Pro Gln Ile Ser Val Ile                 170 175 180 atg ggc gca tgt gca ggt ggc aac gct tac ggc cca gct ctg acc gac 691 Met Gly Ala Cys Ala Gly Gly Asn Ala Tyr Gly Pro Ala Leu Thr Asp             185 190 195 ttc gtg gtc atg gtg gac aag acc tcc aag atg ttc gtt acc ggc cca 739 Phe Val Val Met Val Asp Lys Thr Ser Lys Met Phe Val Thr Gly Pro         200 205 210 gac gtg atc aag acc gtc acc ggc gag gaa atc acc cag gaa gag ctt 787 Asp Val Ile Lys Thr Val Thr Gly Glu Glu Ile Thr Gln Glu Glu Leu     215 220 225 ggc gga gca acc acc cac atg gtg acc gct ggt aac tcc cac tac acc 835 Gly Gly Ala Thr Thr His Met Val Thr Ala Gly Asn Ser His Tyr Thr 230 235 240 245 gct gcg acc gat gag gaa gca ctg gat tgg gta cag gac ctg gtg tcc 883 Ala Ala Thr Asp Glu Glu Ala Leu Asp Trp Val Gln Asp Leu Val Ser                 250 255 260 ttc ctc cca tcc aac aat cgc tcc tac gca ccg atg gaa gac ttc gac 931 Phe Leu Pro Ser Asn Asn Arg Ser Tyr Ala Pro Met Glu Asp Phe Asp             265 270 275 gag gaa gaa ggc ggc gtt gaa gaa aac atc acc gct gac gat ctg aag 979 Glu Glu Glu Gly Gly Val Glu Glu Asn Ile Thr Ala Asp Asp Leu Lys         280 285 290 ctc gac gag atc atc cca gat tcc gcg acc gtt cct tac gac gtc cgc 1027 Leu Asp Glu Ile Ile Pro Asp Ser Ala Thr Val Pro Tyr Asp Val Arg     295 300 305 gat gtc atc gaa tgc ctc acc gac gat ggc gaa tac ctg gaa atc cag 1075 Asp Val Ile Glu Cys Leu Thr Asp Asp Gly Glu Tyr Leu Glu Ile Gln 310 315 320 325 gca gac cgc gca gaa aac gtt gtt att gca ttc ggc cgc atc gaa ggc 1123 Ala Asp Arg Ala Glu Asn Val Val Ile Ala Phe Gly Arg Ile Glu Gly                 330 335 340 cag tcc gtt ggc ttt gtt gcc aac cag cca acc cag ttc gct ggc tgc 1171 Gln Ser Val Gly Phe Val Ala Asn Gln Pro Thr Gln Phe Ala Gly Cys             345 350 355 ctg gac atc gac tcc tct gag aag gca gct cgc ttc gtc cgc acc tgc 1219 Leu Asp Ile Asp Ser Ser Glu Lys Ala Ala Arg Phe Val Arg Thr Cys         360 365 370 gac gcg ttc aac atc cca atc gtc atg ctt gtc gac gtc ccc ggc ttc 1267 Asp Ala Phe Asn Ile Pro Ile Val Met Leu Val Asp Val Pro Gly Phe     375 380 385 ctc cca ggc gca ggc cag gag tac ggt ggc att ctg cgt cgt ggc gca 1315 Leu Pro Gly Ala Gly Gln Glu Tyr Gly Gly Ile Leu Arg Arg Gly Ala 390 395 400 405 aag ctg ctc tac gca tac ggc gaa gca acc gtt cca aag atc acc gtc 1363 Lys Leu Leu Tyr Ala Tyr Gly Glu Ala Thr Val Pro Lys Ile Thr Val                 410 415 420 acc atg cgt aag gct tac ggc gga gcg tac tgc gtg atg ggt tcc aag 1411 Thr Met Arg Lys Ala Tyr Gly Gly Ala Tyr Cys Val Met Gly Ser Lys             425 430 435 ggc ttg ggc tct gac atc aac ctt gca tgg cca acc gca cag atc gcc 1459 Gly Leu Gly Ser Asp Ile Asn Leu Ala Trp Pro Thr Ala Gln Ile Ala         440 445 450 gtc atg ggc gct gct ggc gca gtt gga ttc atc tac cgc aag gag ctc 1507 Val Met Gly Ala Ala Gly Ala Val Gly Phe Ile Tyr Arg Lys Glu Leu     455 460 465 atg gca gct gat gcc aag ggc ctc gat acc gta gct ctg gct aag tcc 1555 Met Ala Ala Asp Ala Lys Gly Leu Asp Thr Val Ala Leu Ala Lys Ser 470 475 480 485 ttc gag cgc gag tat gaa gac cac atg ctc aac ccg tac cac gct gca 1603 Phe Glu Arg Glu Tyr Glu Asp His Met Leu Asn Pro Tyr His Ala Ala                 490 495 500 gaa cgt ggc ctg atc gac gcc gtg atc ctg cca agc gaa acc cgc gga 1651 Glu Arg Gly Leu Ile Asp Ala Val Ile Leu Pro Ser Glu Thr Arg Gly             505 510 515 cag att tcc cgc aac ctt cgc ctg ctc aag cac aag aac gtc act cgc 1699 Gln Ile Ser Arg Asn Leu Arg Leu Leu Lys His Lys Asn Val Thr Arg         520 525 530 cct gct cgc aag cac ggc aac atg cca ctg taaatcggcg aatccataaa 1749 Pro Ala Arg Lys His Gly Asn Met Pro Leu     535 540 ggt 1752 <210> 212 <211> 543 <212> PRT <213> Corynebacterium glutamicum <400> 212 Met Thr Ile Ser Ser Pro Leu Ile Asp Val Ala Asn Leu Pro Asp Ile   1 5 10 15 Asn Thr Thr Ala Gly Lys Ile Ala Asp Leu Lys Ala Arg Arg Ala Glu              20 25 30 Ala His Phe Pro Met Gly Glu Lys Ala Val Glu Lys Val His Ala Ala          35 40 45 Gly Arg Leu Thr Ala Arg Glu Arg Leu Asp Tyr Leu Leu Asp Glu Gly      50 55 60 Ser Phe Ile Glu Thr Asp Gln Leu Ala Arg His Arg Thr Thr Ala Phe  65 70 75 80 Cys Leu Gly Ala Lys Arg Pro Ala Thr Asp Gly Ile Val Thr Gly Trp                  85 90 95 Gly Thr Ile Asp Gly Arg Glu Val Cys Ile Phe Ser Gln Asp Gly Thr             100 105 110 Val Phe Gly Gly Ala Leu Gly Glu Val Tyr Gly Glu Lys Met Ile Lys         115 120 125 Ile Met Glu Leu Ala Ile Asp Thr Gly Arg Pro Leu Ile Gly Leu Tyr     130 135 140 Glu Gly Ala Gly Ala Arg Ile Gln Asp Gly Ala Val Ser Leu Asp Phe 145 150 155 160 Ile Ser Gln Thr Phe Tyr Gln Asn Ile Gln Ala Ser Gly Val Ile Pro                 165 170 175 Gln Ile Ser Val Ile Met Gly Ala Cys Ala Gly Gly Asn Ala Tyr Gly             180 185 190 Pro Ala Leu Thr Asp Phe Val Val Met Val Asp Lys Thr Ser Lys Met         195 200 205 Phe Val Thr Gly Pro Asp Val Ile Lys Thr Val Thr Gly Glu Glu Ile     210 215 220 Thr Gln Glu Glu Leu Gly Gly Ala Thr Thr His Met Val Thr Ala Gly 225 230 235 240 Asn Ser His Tyr Thr Ala Ala Thr Asp Glu Glu Ala Leu Asp Trp Val                 245 250 255 Gln Asp Leu Val Ser Phe Leu Pro Ser Asn Asn Arg Ser Tyr Ala Pro             260 265 270 Met Glu Asp Phe Asp Glu Glu Glu Gly Gly Val Glu Glu Asn Ile Thr         275 280 285 Ala Asp Asp Leu Lys Leu Asp Glu Ile Ile Pro Asp Ser Ala Thr Val     290 295 300 Pro Tyr Asp Val Arg Asp Val Ile Glu Cys Leu Thr Asp Asp Gly Glu 305 310 315 320 Tyr Leu Glu Ile Gln Ala Asp Arg Ala Glu Asn Val Val Ile Ala Phe                 325 330 335 Gly Arg Ile Glu Gly Gln Ser Val Gly Phe Val Ala Asn Gln Pro Thr             340 345 350 Gln Phe Ala Gly Cys Leu Asp Ile Asp Ser Ser Glu Lys Ala Ala Arg         355 360 365 Phe Val Arg Thr Cys Asp Ala Phe Asn Ile Pro Ile Val Met Leu Val     370 375 380 Asp Val Pro Gly Phe Leu Pro Gly Ala Gly Gln Glu Tyr Gly Gly Ile 385 390 395 400 Leu Arg Arg Gly Ala Lys Leu Leu Tyr Ala Tyr Gly Glu Ala Thr Val                 405 410 415 Pro Lys Ile Thr Val Thr Met Arg Lys Ala Tyr Gly Gly Ala Tyr Cys             420 425 430 Val Met Gly Ser Lys Gly Leu Gly Ser Asp Ile Asn Leu Ala Trp Pro         435 440 445 Thr Ala Gln Ile Ala Val Met Gly Ala Ala Gly Ala Val Gly Phe Ile     450 455 460 Tyr Arg Lys Glu Leu Met Ala Ala Asp Ala Lys Gly Leu Asp Thr Val 465 470 475 480 Ala Leu Ala Lys Ser Phe Glu Arg Glu Tyr Glu Asp His Met Leu Asn                 485 490 495 Pro Tyr His Ala Ala Glu Arg Gly Leu Ile Asp Ala Val Ile Leu Pro             500 505 510 Ser Glu Thr Arg Gly Gln Ile Ser Arg Asn Leu Arg Leu Leu Lys His         515 520 525 Lys Asn Val Thr Arg Pro Ala Arg Lys His Gly Asn Met Pro Leu     530 535 540 <210> 213 <211> 467 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (444) <223> FRXA02321 <220> <221> misc_feature <222> 50 <223> n indicates any nucleotide <220> <221> misc_feature <222> 51 <223> n indicates any nucleotide <220> <221> VARIANT <222> 17 Xaa = Val, Ala, Asp, Glu, or Gly <400> 213 gag tac ggt ggc att ctg cgt cgt ggc gca aag ctg ctc tac gca tcg 48 Glu Tyr Gly Gly Ile Leu Arg Arg Gly Ala Lys Leu Leu Tyr Ala Ser   1 5 10 15 gnn gaa gca ccg gtt cca aag atc acc gtc acc atg cgt aag gct tac 96 Xaa Glu Ala Pro Val Pro Lys Ile Thr Val Thr Met Arg Lys Ala Tyr              20 25 30 ggc gga gcg tac tgc gtg atg ggt tcc aag ggc ttg ggc tct gac atc 144 Gly Gly Ala Tyr Cys Val Met Gly Ser Lys Gly Leu Gly Ser Asp Ile          35 40 45 aac ctt gca tgg cca acc gca cag atc gcc gtc atg ggc gct gct ggc 192 Asn Leu Ala Trp Pro Thr Ala Gln Ile Ala Val Met Gly Ala Ala Gly      50 55 60 gca gtt gga ttc atc tac cgc aag gag ctc atg gca gct gat gcc aag 240 Ala Val Gly Phe Ile Tyr Arg Lys Glu Leu Met Ala Ala Asp Ala Lys  65 70 75 80 ggc ctc gat acc gta gct ctg gct aag tcc ttc gag cgc gag tat gaa 288 Gly Leu Asp Thr Val Ala Leu Ala Lys Ser Phe Glu Arg Glu Tyr Glu                  85 90 95 gac cac atg ctc aac ccg tac cac gct gca gaa cgt ggc ctg atc gac 336 Asp His Met Leu Asn Pro Tyr His Ala Ala Glu Arg Gly Leu Ile Asp             100 105 110 gcc gtg atc ctg cca agc gaa acc cgc gga cag att tcc cgc aac ctt 384 Ala Val Ile Leu Pro Ser Glu Thr Arg Gly Gln Ile Ser Arg Asn Leu         115 120 125 cgc ctg ctc aag cac aag aac gtc act cgc cct gct cgc aag cac ggc 432 Arg Leu Leu Lys His Lys Asn Val Thr Arg Pro Ala Arg Lys His Gly     130 135 140 aac atg cca ctg taaatcggcg aatccataaa ggt 467 Asn Met Pro Leu 145 <210> 214 <211> 148 <212> PRT <213> Corynebacterium glutamicum <220> <221> VARIANT <222> 17 Xaa = Val, Ala, Asp, Glu, or Gly <400> 214 Glu Tyr Gly Gly Ile Leu Arg Arg Gly Ala Lys Leu Leu Tyr Ala Ser   1 5 10 15 Xaa Glu Ala Pro Val Pro Lys Ile Thr Val Thr Met Arg Lys Ala Tyr              20 25 30 Gly Gly Ala Tyr Cys Val Met Gly Ser Lys Gly Leu Gly Ser Asp Ile          35 40 45 Asn Leu Ala Trp Pro Thr Ala Gln Ile Ala Val Met Gly Ala Ala Gly      50 55 60 Ala Val Gly Phe Ile Tyr Arg Lys Glu Leu Met Ala Ala Asp Ala Lys  65 70 75 80 Gly Leu Asp Thr Val Ala Leu Ala Lys Ser Phe Glu Arg Glu Tyr Glu                  85 90 95 Asp His Met Leu Asn Pro Tyr His Ala Ala Glu Arg Gly Leu Ile Asp             100 105 110 Ala Val Ile Leu Pro Ser Glu Thr Arg Gly Gln Ile Ser Arg Asn Leu         115 120 125 Arg Leu Leu Lys His Lys Asn Val Thr Arg Pro Ala Arg Lys His Gly     130 135 140 Asn Met Pro Leu 145 <210> 215 <211> 514 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (514) <223> FRXA02343 <400> 215 tttaaaaact acccgcacgc agcacgaacc tgttcagtga tgtaaatcac cgcggaaata 60 ttgtggacgt tacccccgcc taccgctacg atttcaaaac atg acc att tcc tca 115                                             Met Thr Ile Ser Ser                                               1 5 cct ttg att gac gtc gcc aac ctt cca gac atc aac acc act gcc ggc 163 Pro Leu Ile Asp Val Ala Asn Leu Pro Asp Ile Asn Thr Thr Ala Gly                  10 15 20 aag atc gcc gac ctt aag gct cgc cgc gcg gaa gcc cat ttc ccc atg 211 Lys Ile Ala Asp Leu Lys Ala Arg Arg Ala Glu Ala His Phe Pro Met              25 30 35 ggt gaa aag gca gta gag aag gtc cac gct gct gga cgc ctc act gcc 259 Gly Glu Lys Ala Val Glu Lys Val His Ala Ala Gly Arg Leu Thr Ala          40 45 50 cgt gag cgc ttg gat tac tta ctc gat gag ggc tcc ttc atc gag acc 307 Arg Glu Arg Leu Asp Tyr Leu Leu Asp Glu Gly Ser Phe Ile Glu Thr      55 60 65 gat cag ctg gct cgc cac cgc acc acc gct ttc tgc ctg ggc gct aag 355 Asp Gln Leu Ala Arg His Arg Thr Thr Ala Phe Cys Leu Gly Ala Lys  70 75 80 85 cgt cct gca acc gac ggc atc gtg acc ggc tgg ggc acc att gat gga 403 Arg Pro Ala Thr Asp Gly Ile Val Thr Gly Trp Gly Thr Ile Asp Gly                  90 95 100 cgc gaa gtc tgc atc ttc tcg cag gac ggc acc gta ttc ggt ggc gcg 451 Arg Glu Val Cys Ile Phe Ser Gln Asp Gly Thr Val Phe Gly Gly Ala             105 110 115 ctt ggt gag gtg tac ggc gaa aag atg atc aag atc atg gag ctg gca 499 Leu Gly Glu Val Tyr Gly Glu Lys Met Ile Lys Ile Met Glu Leu Ala         120 125 130 atc gac acc ggc cgc 514 Ile Asp Thr Gly Arg     135 <210> 216 <211> 138 <212> PRT <213> Corynebacterium glutamicum <400> 216 Met Thr Ile Ser Ser Pro Leu Ile Asp Val Ala Asn Leu Pro Asp Ile   1 5 10 15 Asn Thr Thr Ala Gly Lys Ile Ala Asp Leu Lys Ala Arg Arg Ala Glu              20 25 30 Ala His Phe Pro Met Gly Glu Lys Ala Val Glu Lys Val His Ala Ala          35 40 45 Gly Arg Leu Thr Ala Arg Glu Arg Leu Asp Tyr Leu Leu Asp Glu Gly      50 55 60 Ser Phe Ile Glu Thr Asp Gln Leu Ala Arg His Arg Thr Thr Ala Phe  65 70 75 80 Cys Leu Gly Ala Lys Arg Pro Ala Thr Asp Gly Ile Val Thr Gly Trp                  85 90 95 Gly Thr Ile Asp Gly Arg Glu Val Cys Ile Phe Ser Gln Asp Gly Thr             100 105 110 Val Phe Gly Gly Ala Leu Gly Glu Val Tyr Gly Glu Lys Met Ile Lys         115 120 125 Ile Met Glu Leu Ala Ile Asp Thr Gly Arg     130 135 <210> 217 <211> 492 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (492) <223> FRXA02850 <220> <221> misc_feature <222> 258 <223> n indicates any nucleotide <220> <221> misc_feature <222> 302 <223> n indicates any nucleotide <220> <221> VARIANT <222> 86 <223> Xaa = Ile or Met <220> <221> VARIANT <222> 101 <223> Xaa = Val, Ala, Asp, or Gly <400> 217 gaa gag ctt ggc gga gca acc acc cac atg gtg acc gct ggt aac tcc 48 Glu Glu Leu Gly Gly Ala Thr Thr His Met Val Thr Ala Gly Asn Ser   1 5 10 15 cac tac acc gct gcg acc gat gag gaa gca ctg gat tgg gta cag gac 96 His Tyr Thr Ala Ala Thr Asp Glu Glu Ala Leu Asp Trp Val Gln Asp              20 25 30 ctg gtg tcc ttc ctc cca tcc aac aat cgc tcc tac gca ccg atg gaa 144 Leu Val Ser Phe Leu Pro Ser Asn Asn Arg Ser Tyr Ala Pro Met Glu          35 40 45 gac ttc gac gag gaa gaa ggc ggc gtt gaa gaa aac atc acc gct gac 192 Asp Phe Asp Glu Glu Glu Gly Gly Val Glu Glu Asn Ile Thr Ala Asp      50 55 60 gat ctg aag ctc gac gag atc atc cca gat tcc gcg acc gtt cct tac 240 Asp Leu Lys Leu Asp Glu Ile Ile Pro Asp Ser Ala Thr Val Pro Tyr  65 70 75 80 gac gtc cgc gat gtc atn gaa tgc ctc acc gac gat ggc gaa tac ctg 288 Asp Val Arg Asp Val Xaa Glu Cys Leu Thr Asp Asp Gly Glu Tyr Leu                  85 90 95 gaa atc cag gca gnc cgc gca gaa aac gtt gtt att gca ttc ggc cgc 336 Glu Ile Gln Ala Xaa Arg Ala Glu Asn Val Val Ile Ala Phe Gly Arg             100 105 110 atc gaa ggc cag tcc gtt ggc ttt gtt gcc aac cag cca acc cag ttc 384 Ile Glu Gly Gln Ser Val Gly Phe Val Ala Asn Gln Pro Thr Gln Phe         115 120 125 gct ggc tgc ctg gac atc gac tcc tct gag aag gca gct cgc ttc gtc 432 Ala Gly Cys Leu Asp Ile Asp Ser Ser Glu Lys Ala Ala Arg Phe Val     130 135 140 cgc acc tgc gac gcg ttc aac atc cca atc gtc atg ctt gtg gac gtc 480 Arg Thr Cys Asp Ala Phe Asn Ile Pro Ile Val Met Leu Val Asp Val 145 150 155 160 ccc ggc ttc ctc 492 Pro Gly Phe Leu <210> 218 <211> 164 <212> PRT <213> Corynebacterium glutamicum <220> <221> VARIANT <222> 86 <223> Xaa = Ile or Met <220> <221> VARIANT <222> 101 <223> Xaa = Val, Ala, Asp, or Gly <400> 218 Glu Glu Leu Gly Gly Ala Thr Thr His Met Val Thr Ala Gly Asn Ser   1 5 10 15 His Tyr Thr Ala Ala Thr Asp Glu Glu Ala Leu Asp Trp Val Gln Asp              20 25 30 Leu Val Ser Phe Leu Pro Ser Asn Asn Arg Ser Tyr Ala Pro Met Glu          35 40 45 Asp Phe Asp Glu Glu Glu Gly Gly Val Glu Glu Asn Ile Thr Ala Asp      50 55 60 Asp Leu Lys Leu Asp Glu Ile Ile Pro Asp Ser Ala Thr Val Pro Tyr  65 70 75 80 Asp Val Arg Asp Val Xaa Glu Cys Leu Thr Asp Asp Gly Glu Tyr Leu                  85 90 95 Glu Ile Gln Ala Xaa Arg Ala Glu Asn Val Val Ile Ala Phe Gly Arg             100 105 110 Ile Glu Gly Gln Ser Val Gly Phe Val Ala Asn Gln Pro Thr Gln Phe         115 120 125 Ala Gly Cys Leu Asp Ile Asp Ser Ser Glu Lys Ala Ala Arg Phe Val     130 135 140 Arg Thr Cys Asp Ala Phe Asn Ile Pro Ile Val Met Leu Val Asp Val 145 150 155 160 Pro Gly Phe Leu <210> 219 <211> 1671 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1648) <223> RXA02583 <400> 219 cagttgtcga tgaaccagaa atcggcacag tcggagctca tttgagtcgc cgcattgatg 60 agatttctcg gaagaattag taacggagag ctgacggaag ttg agt aac acc act 115                                             Leu Ser Asn Thr Thr                                               1 5 act gca gag aag cta gcg gat ctg cgc gca cgc ctg gag att gcc aaa 163 Thr Ala Glu Lys Leu Ala Asp Leu Arg Ala Arg Leu Glu Ile Ala Lys                  10 15 20 gac cca ggt agt gaa cgc gca cgt aaa aag cgc gac gag gaa ggc cga 211 Asp Pro Gly Ser Glu Arg Ala Arg Lys Lys Arg Asp Glu Glu Gly Arg              25 30 35 acc acc cct cgt cag cgt att gat gct ctg ctt gat gcc gga tcc ttt 259 Thr Thr Pro Arg Gln Arg Ile Asp Ala Leu Leu Asp Ala Gly Ser Phe          40 45 50 gtg gag atc ggc gca cta ggc cgt acc ccg gat gaa ccc gat gcg cct 307 Val Glu Ile Gly Ala Leu Gly Arg Thr Pro Asp Glu Pro Asp Ala Pro      55 60 65 tac tct gac ggt gtg gtg act ggt tat ggt cgc atc gat ggt cgc cca 355 Tyr Ser Asp Gly Val Val Thr Gly Tyr Gly Arg Ile Asp Gly Arg Pro  70 75 80 85 gtg gcc atc tac gcc cat gac aag acc gtt tac ggt ggt tcc gtg ggc 403 Val Ala Ile Tyr Ala His Asp Lys Thr Val Tyr Gly Gly Ser Val Gly                  90 95 100 atg act ttc gga cgt aaa gtc agc gaa gtc atg gac atg gct atc cgc 451 Met Thr Phe Gly Arg Lys Val Ser Glu Val Met Asp Met Ala Ile Arg             105 110 115 att ggt tgc cca gtt atc ggt att cag gat tcc ggc gga gcc cgc att 499 Ile Gly Cys Pro Val Ile Gly Ile Gln Asp Ser Gly Gly Ala Arg Ile         120 125 130 cag gat gcg gtg acc tcc ttg gcg atg tac tca gag atc gcg cgt cgt 547 Gln Asp Ala Val Thr Ser Leu Ala Met Tyr Ser Glu Ile Ala Arg Arg     135 140 145 cag ctt ccg ctg tct ggc cgc agc cct cag att tcc atc atg ctg ggt 595 Gln Leu Pro Leu Ser Gly Arg Ser Pro Gln Ile Ser Ile Met Leu Gly 150 155 160 165 aaa tcg gca ggt ggc gca gtg tat gca cct gtg acc act gac ttt gtt 643 Lys Ser Ala Gly Gly Ala Val Tyr Ala Pro Val Thr Thr Asp Phe Val                 170 175 180 atc ggc gtt gat ggt gaa aca gaa atg tat gtc acc ggc cca gcc gtg 691 Ile Gly Val Asp Gly Glu Thr Glu Met Tyr Val Thr Gly Pro Ala Val             185 190 195 atc aag gaa gtc acc ggc gag cag atc act tcc gca gac ctc ggt ggc 739 Ile Lys Glu Val Thr Gly Glu Gln Ile Thr Ser Ala Asp Leu Gly Gly         200 205 210 ggt gcg cag cag atg caa aac ggc aac att tcc tat ttg gcg tcc tct 787 Gly Ala Gln Gln Met Gln Asn Gly Asn Ile Ser Tyr Leu Ala Ser Ser     215 220 225 gaa gaa gag gcc ctg aat atg gtc aag gat ttg ctc gac ttc ctg cct 835 Glu Glu Glu Ala Leu Asn Met Val Lys Asp Leu Leu Asp Phe Leu Pro 230 235 240 245 ttg acc tgc aat gat cca gcc cct gtg ttt gca gca cca acg gat gaa 883 Leu Thr Cys Asn Asp Pro Ala Pro Val Phe Ala Ala Pro Thr Asp Glu                 250 255 260 gag atc gcc tac gac gaa gct ctg aac tcg ttc atg cct gac gac act 931 Glu Ile Ala Tyr Asp Glu Ala Leu Asn Ser Phe Met Pro Asp Asp Thr             265 270 275 aac cag ggc tac gac atg cat gac ctg ctg gac aag ctt ttc gac gac 979 Asn Gln Gly Tyr Asp Met His Asp Leu Leu Asp Lys Leu Phe Asp Asp         280 285 290 gcc aac ctg ctg gaa atc caa gag gag tac gcc ccc aac ctg atc act 1027 Ala Asn Leu Leu Glu Ile Gln Glu Glu Tyr Ala Pro Asn Leu Ile Thr     295 300 305 acc ttc gcc cgc gtt gat ggc aag gca gtc ggt gtg gtg gcc aac caa 1075 Thr Phe Ala Arg Val Asp Gly Lys Ala Val Gly Val Val Ala Asn Gln 310 315 320 325 cca atg gat aag gca ggc tgc atc gac gct gac gcc gcc gac aag ggc 1123 Pro Met Asp Lys Ala Gly Cys Ile Asp Ala Asp Ala Ala Asp Lys Gly                 330 335 340 gcc cgc ttc atc cgt atc tgc gac gcc tac aac atc ccg atc atc ttc 1171 Ala Arg Phe Ile Arg Ile Cys Asp Ala Tyr Asn Ile Pro Ile Ile Phe             345 350 355 gtc gtg gac acc cct ggc tac ctg cct ggc gtg gac caa gag aag gtc 1219 Val Val Asp Thr Pro Gly Tyr Leu Pro Gly Val Asp Gln Glu Lys Val         360 365 370 ggt ttg att cac cgt ggc gca aag cta gcc ttc gca gtg gtg gaa tcg 1267 Gly Leu Ile His Arg Gly Ala Lys Leu Ala Phe Ala Val Val Glu Ser     375 380 385 acc gtc cct aag att tcc ttg atc gtg cgc aag gcc tac ggc gga gca 1315 Thr Val Pro Lys Ile Ser Leu Ile Val Arg Lys Ala Tyr Gly Gly Ala 390 395 400 405 tat gcc gtg atg ggt tcc aag aac ctc acc ggt gac ctc aac ttc gca 1363 Tyr Ala Val Met Gly Ser Lys Asn Leu Thr Gly Asp Leu Asn Phe Ala                 410 415 420 tgg cca acc gca cag atc gcc gtg atg ggc gca gcc gca gct gtc gtg 1411 Trp Pro Thr Ala Gln Ile Ala Val Met Gly Ala Ala Ala Ala Val Val             425 430 435 atg atc cag ggc aag cag ctc gaa gcc gcc cca cct gag cag cgt gaa 1459 Met Ile Gln Gly Lys Gln Leu Glu Ala Ala Pro Pro Glu Gln Arg Glu         440 445 450 tac atg aag aaa ctg ttc atg gac ttc tac gat gag aac atg acc agc 1507 Tyr Met Lys Lys Leu Phe Met Asp Phe Tyr Asp Glu Asn Met Thr Ser     455 460 465 cca tat gtg gcc gcc gag cgt ggt tac atc gac gcc atg atc gaa cct 1555 Pro Tyr Val Ala Ala Glu Arg Gly Tyr Ile Asp Ala Met Ile Glu Pro 470 475 480 485 gca gag acc cgt ttg gtg ctt cgc cga gca gtc cgc cag ctg gaa acc 1603 Ala Glu Thr Arg Leu Val Leu Arg Arg Ala Val Arg Gln Leu Glu Thr                 490 495 500 aag gct gtg cga gac ctc gac aag aag cac acg atc atg ccg atg 1648 Lys Ala Val Arg Asp Leu Asp Lys Lys His Thr Ile Met Pro Met             505 510 515 taacgtccaa agaattatcc aga 1671 <210> 220 <211> 516 <212> PRT <213> Corynebacterium glutamicum <400> 220 Leu Ser Asn Thr Thr Thr Ala Glu Lys Leu Ala Asp Leu Arg Ala Arg   1 5 10 15 Leu Glu Ile Ala Lys Asp Pro Gly Ser Glu Arg Ala Arg Lys Lys Arg              20 25 30 Asp Glu Glu Gly Arg Thr Thr Pro Arg Gln Arg Ile Asp Ala Leu Leu          35 40 45 Asp Ala Gly Ser Phe Val Glu Ile Gly Ala Leu Gly Arg Thr Pro Asp      50 55 60 Glu Pro Asp Ala Pro Tyr Ser Asp Gly Val Val Thr Gly Tyr Gly Arg  65 70 75 80 Ile Asp Gly Arg Pro Val Ala Ile Tyr Ala His Asp Lys Thr Val Tyr                  85 90 95 Gly Gly Ser Val Gly Met Thr Phe Gly Arg Lys Val Ser Glu Val Met             100 105 110 Asp Met Ala Ile Arg Ile Gly Cys Pro Val Ile Gly Ile Gln Asp Ser         115 120 125 Gly Gly Ala Arg Ile Gln Asp Ala Val Thr Ser Leu Ala Met Tyr Ser     130 135 140 Glu Ile Ala Arg Arg Gln Leu Pro Leu Ser Gly Arg Ser Pro Gln Ile 145 150 155 160 Ser Ile Met Leu Gly Lys Ser Ala Gly Gly Ala Val Tyr Ala Pro Val                 165 170 175 Thr Thr Asp Phe Val Ile Gly Val Asp Gly Glu Thr Glu Met Tyr Val             180 185 190 Thr Gly Pro Ala Val Ile Lys Glu Val Thr Gly Glu Gln Ile Thr Ser         195 200 205 Ala Asp Leu Gly Gly Gly Ala Gln Gln Met Gln Asn Gly Asn Ile Ser     210 215 220 Tyr Leu Ala Ser Ser Glu Glu Glu Ala Leu Asn Met Val Lys Asp Leu 225 230 235 240 Leu Asp Phe Leu Pro Leu Thr Cys Asn Asp Pro Ala Pro Val Phe Ala                 245 250 255 Ala Pro Thr Asp Glu Glu Ile Ala Tyr Asp Glu Ala Leu Asn Ser Phe             260 265 270 Met Pro Asp Asp Thr Asn Gln Gly Tyr Asp Met His Asp Leu Leu Asp         275 280 285 Lys Leu Phe Asp Asp Ala Asn Leu Leu Glu Ile Gln Glu Glu Tyr Ala     290 295 300 Pro Asn Leu Ile Thr Thr Phe Ala Arg Val Asp Gly Lys Ala Val Gly 305 310 315 320 Val Val Ala Asn Gln Pro Met Asp Lys Ala Gly Cys Ile Asp Ala Asp                 325 330 335 Ala Ala Asp Lys Gly Ala Arg Phe Ile Arg Ile Cys Asp Ala Tyr Asn             340 345 350 Ile Pro Ile Ile Phe Val Val Asp Thr Pro Gly Tyr Leu Pro Gly Val         355 360 365 Asp Gln Glu Lys Val Gly Leu Ile His Arg Gly Ala Lys Leu Ala Phe     370 375 380 Ala Val Val Glu Ser Thr Val Pro Lys Ile Ser Leu Ile Val Arg Lys 385 390 395 400 Ala Tyr Gly Gly Ala Tyr Ala Val Met Gly Ser Lys Asn Leu Thr Gly                 405 410 415 Asp Leu Asn Phe Ala Trp Pro Thr Ala Gln Ile Ala Val Met Gly Ala             420 425 430 Ala Ala Ala Val Val Met Ile Gln Gly Lys Gln Leu Glu Ala Ala Pro         435 440 445 Pro Glu Gln Arg Glu Tyr Met Lys Lys Leu Phe Met Asp Phe Tyr Asp     450 455 460 Glu Asn Met Thr Ser Pro Tyr Val Ala Ala Glu Arg Gly Tyr Ile Asp 465 470 475 480 Ala Met Ile Glu Pro Ala Glu Thr Arg Leu Val Leu Arg Arg Ala Val                 485 490 495 Arg Gln Leu Glu Thr Lys Ala Val Arg Asp Leu Asp Lys Lys His Thr             500 505 510 Ile Met Pro Met         515 <210> 221 <211> 1635 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1612) <223> RXA00870 <400> 221 caagacggcg atgtcgccgc cgctgttgat accgcagcgc gacttgttca cacagatatt 60 caacaattca cttcgcagag catttaagga atttacacac atg tct gaa cca caa 115                                             Met Ser Glu Pro Gln                                               1 5 acc atc tcg cac tgg att gac ggc gcg att tcc cca tcc act tcc ggc 163 Thr Ile Ser His Trp Ile Asp Gly Ala Ile Ser Pro Ser Thr Ser Gly                  10 15 20 aag acc gct cct gtc tac aat cct gca act ggc cag gtc acc gcc aat 211 Lys Thr Ala Pro Val Tyr Asn Pro Ala Thr Gly Gln Val Thr Ala Asn              25 30 35 gtt gcg ctg gct agc cag gaa gag atc gat gcc acc atc gct tct gcc 259 Val Ala Leu Ala Ser Gln Glu Glu Ile Asp Ala Thr Ile Ala Ser Ala          40 45 50 acc aag gct gct aag acg tgg ggc aac ctg tct atc gct aag cgc caa 307 Thr Lys Ala Ala Lys Thr Trp Gly Asn Leu Ser Ile Ala Lys Arg Gln      55 60 65 gct gtg ctt ttc aac ttc cgt gag ctg ctg aat gct cgc aag ggt gag 355 Ala Val Leu Phe Asn Phe Arg Glu Leu Leu Asn Ala Arg Lys Gly Glu  70 75 80 85 ctg gcg gag atc atc act gca gag cac ggc aag gtc ttg tcc gat gcc 403 Leu Ala Glu Ile Ile Thr Ala Glu His Gly Lys Val Leu Ser Asp Ala                  90 95 100 atg ggt gaa atc ctg cgc ggc cag gaa gtc gtg gag ctt gct acc ggt 451 Met Gly Glu Ile Leu Arg Gly Gln Glu Val Val Glu Leu Ala Thr Gly             105 110 115 ttc cca cac ctg ctt aaa ggt gcg ttc aac gag aac gtc tcc acc ggc 499 Phe Pro His Leu Leu Lys Gly Ala Phe Asn Glu Asn Val Ser Thr Gly         120 125 130 att gat gtg tat tcc ttg aag cag cca ctg ggt gtt gtc ggt atc atc 547 Ile Asp Val Tyr Ser Leu Lys Gln Pro Leu Gly Val Val Gly Ile Ile     135 140 145 agc ccg ttc aac ttc cct gcg atg gtg ccg atg tgg ttt ttc cca atc 595 Ser Pro Phe Asn Phe Pro Ala Met Val Pro Met Trp Phe Phe Pro Ile 150 155 160 165 gca atc gct gca ggc aac gca gtt att ttg aag cct tca gag aag gat 643 Ala Ile Ala Ala Gly Asn Ala Val Ile Leu Lys Pro Ser Glu Lys Asp                 170 175 180 cct tcg gca gcg ctg tgg atg gct cag atc tgg aag gaa gct ggt ctt 691 Pro Ser Ala Ala Leu Trp Met Ala Gln Ile Trp Lys Glu Ala Gly Leu             185 190 195 cca gac ggc gta ttc aac gtg ctc cag ggc gac aag ctg gct gtt gat 739 Pro Asp Gly Val Phe Asn Val Leu Gln Gly Asp Lys Leu Ala Val Asp         200 205 210 ggt ttg ctg aac agc cct gat gtc tct gcg att tcc ttc gtg ggt tcc 787 Gly Leu Leu Asn Ser Pro Asp Val Ser Ala Ile Ser Phe Val Gly Ser     215 220 225 acc cca atc gca aag tac atc tac gag act tcc gcg aag aac ggc aag 835 Thr Pro Ile Ala Lys Tyr Ile Tyr Glu Thr Ser Ala Lys Asn Gly Lys 230 235 240 245 cgc gtc cag gcg ttg ggc ggc gcg aag aac cac atg ctg gtg ctg cca 883 Arg Val Gln Ala Leu Gly Gly Ala Lys Asn His Met Leu Val Leu Pro                 250 255 260 gat gct gat ctg gat ctg gtt gcc gat cag gca atc aac gca ggt tac 931 Asp Ala Asp Leu Asp Leu Val Ala Asp Gln Ala Ile Asn Ala Gly Tyr             265 270 275 ggc gct gcc ggt gag cgt tgc atg gct gtt tct gtg gtc ttg gct att 979 Gly Ala Ala Gly Glu Arg Cys Met Ala Val Ser Val Val Leu Ala Ile         280 285 290 gaa tct gtt gcc gac gag ctc att gag aag atc aag gag cgc atc gac 1027 Glu Ser Val Ala Asp Glu Leu Ile Glu Lys Ile Lys Glu Arg Ile Asp     295 300 305 acc ctg cgc atc ggc aac ggt gcc ggc gac gag cag ggc gag ccg cac 1075 Thr Leu Arg Ile Gly Asn Gly Ala Gly Asp Glu Gln Gly Glu Pro His 310 315 320 325 ctg ggc cca cta atc acc gac gtc cac cgc gac aag gtc gct tct tat 1123 Leu Gly Pro Leu Ile Thr Asp Val His Arg Asp Lys Val Ala Ser Tyr                 330 335 340 gtc gac atc gct gag gcc gac ggc gcc aag atc atc gtg gac ggg cgt 1171 Val Asp Ile Ala Glu Ala Asp Gly Ala Lys Ile Ile Val Asp Gly Arg             345 350 355 aac tgc gcc gta gac ggg cac gag gag ggc ttc ttc ttc ggc cct acg 1219 Asn Cys Ala Val Asp Gly His Glu Glu Gly Phe Phe Phe Gly Pro Thr         360 365 370 ctt atc gac gac atc cca ctc acg ttc cgc gcc tac acc gaa gaa atc 1267 Leu Ile Asp Asp Ile Pro Leu Thr Phe Arg Ala Tyr Thr Glu Glu Ile     375 380 385 ttc ggc ccg gtc ctc tct gtc gtt cgt gtc gca tcc ttc gac gag gca 1315 Phe Gly Pro Val Leu Ser Val Val Arg Val Ala Ser Phe Asp Glu Ala 390 395 400 405 att gag ctg atc aac tcc ggt gaa ttc ggc aac gga acc gca atc ttc 1363 Ile Glu Leu Ile Asn Ser Gly Glu Phe Gly Asn Gly Thr Ala Ile Phe                 410 415 420 acc aac gat ggt gga gcg gca cgc cgc ttc cag cat gag atc gaa gtg 1411 Thr Asn Asp Gly Gly Ala Ala Arg Arg Phe Gln His Glu Ile Glu Val             425 430 435 ggc atg atc ggc atc aac gta cca atc cca gtg cct gtt gcg tac cac 1459 Gly Met Ile Gly Ile Asn Val Pro Ile Pro Val Pro Val Ala Tyr His         440 445 450 tcc ttc ggt ggt tgg aag aac tcc ctc ttc ggt gac gcc aag gca tat 1507 Ser Phe Gly Gly Trp Lys Asn Ser Leu Phe Gly Asp Ala Lys Ala Tyr     455 460 465 ggc act caa ggt ttt gat ttc ttc acc agg gaa aag gcg atc acc agc 1555 Gly Thr Gln Gly Phe Asp Phe Phe Thr Arg Glu Lys Ala Ile Thr Ser 470 475 480 485 cgt tgg ctc gac cca gca acc cac ggt ggc att aac ctc ggt ttc cca 1603 Arg Trp Leu Asp Pro Ala Thr His Gly Gly Ile Asn Leu Gly Phe Pro                 490 495 500 cag aac gat taattgaagg agagcacagg act 1635 Gln Asn Asp <210> 222 <211> 504 <212> PRT <213> Corynebacterium glutamicum <400> 222 Met Ser Glu Pro Gln Thr Ile Ser His Trp Ile Asp Gly Ala Ile Ser   1 5 10 15 Pro Ser Thr Ser Gly Lys Thr Ala Pro Val Tyr Asn Pro Ala Thr Gly              20 25 30 Gln Val Thr Ala Asn Val Ala Leu Ala Ser Gln Glu Glu Ile Asp Ala          35 40 45 Thr Ile Ala Ser Ala Thr Lys Ala Ala Lys Thr Trp Gly Asn Leu Ser      50 55 60 Ile Ala Lys Arg Gln Ala Val Leu Phe Asn Phe Arg Glu Leu Leu Asn  65 70 75 80 Ala Arg Lys Gly Glu Leu Ala Glu Ile Ile Thr Ala Glu His Gly Lys                  85 90 95 Val Leu Ser Asp Ala Met Gly Glu Ile Leu Arg Gly Gln Glu Val Val             100 105 110 Glu Leu Ala Thr Gly Phe Pro His Leu Leu Lys Gly Ala Phe Asn Glu         115 120 125 Asn Val Ser Thr Gly Ile Asp Val Tyr Ser Leu Lys Gln Pro Leu Gly     130 135 140 Val Val Gly Ile Ile Ser Pro Phe Asn Phe Pro Ala Met Val Pro Met 145 150 155 160 Trp Phe Phe Pro Ile Ala Ile Ala Ala Gly Asn Ala Val Ile Leu Lys                 165 170 175 Pro Ser Glu Lys Asp Pro Ser Ala Ala Leu Trp Met Ala Gln Ile Trp             180 185 190 Lys Glu Ala Gly Leu Pro Asp Gly Val Phe Asn Val Leu Gln Gly Asp         195 200 205 Lys Leu Ala Val Asp Gly Leu Leu Asn Ser Pro Asp Val Ser Ala Ile     210 215 220 Ser Phe Val Gly Ser Thr Pro Ile Ala Lys Tyr Ile Tyr Glu Thr Ser 225 230 235 240 Ala Lys Asn Gly Lys Arg Val Gln Ala Leu Gly Gly Ala Lys Asn His                 245 250 255 Met Leu Val Leu Pro Asp Ala Asp Leu Asp Leu Val Ala Asp Gln Ala             260 265 270 Ile Asn Ala Gly Tyr Gly Ala Ala Gly Glu Arg Cys Met Ala Val Ser         275 280 285 Val Val Leu Ala Ile Glu Ser Val Ala Asp Glu Leu Ile Glu Lys Ile     290 295 300 Lys Glu Arg Ile Asp Thr Leu Arg Ile Gly Asn Gly Ala Gly Asp Glu 305 310 315 320 Gln Gly Glu Pro His Leu Gly Pro Leu Ile Thr Asp Val His Arg Asp                 325 330 335 Lys Val Ala Ser Tyr Val Asp Ile Ala Glu Ala Asp Gly Ala Lys Ile             340 345 350 Ile Val Asp Gly Arg Asn Cys Ala Val Asp Gly His Glu Glu Gly Phe         355 360 365 Phe Phe Gly Pro Thr Leu Ile Asp Asp Ile Pro Leu Thr Phe Arg Ala     370 375 380 Tyr Thr Glu Glu Ile Phe Gly Pro Val Leu Ser Val Val Arg Val Ala 385 390 395 400 Ser Phe Asp Glu Ala Ile Glu Leu Ile Asn Ser Gly Glu Phe Gly Asn                 405 410 415 Gly Thr Ala Ile Phe Thr Asn Asp Gly Gly Ala Ala Arg Arg Phe Gln             420 425 430 His Glu Ile Glu Val Gly Met Ile Gly Ile Asn Val Pro Ile Pro Val         435 440 445 Pro Val Ala Tyr His Ser Phe Gly Gly Trp Lys Asn Ser Leu Phe Gly     450 455 460 Asp Ala Lys Ala Tyr Gly Thr Gln Gly Phe Asp Phe Phe Thr Arg Glu 465 470 475 480 Lys Ala Ile Thr Ser Arg Trp Leu Asp Pro Ala Thr His Gly Gly Ile                 485 490 495 Asn Leu Gly Phe Pro Gln Asn Asp             500 <210> 223 <211> 1305 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (1282) <223> RXA01260 <400> 223 ctaaacgtgg gctgcattcc ttccaaagtc tctgatcaaa aacgctgaag ttgcccatac 60 ctttacccat gagaagaaga ccttcggcat caatggcgaa gtg acc ttc aac tat 115                                             Val Thr Phe Asn Tyr                                               1 5 gag gat gct cac aag cgt tcc cgt ggc gtt tcc gac aag atc gtt gga 163 Glu Asp Ala His Lys Arg Ser Arg Gly Val Ser Asp Lys Ile Val Gly                  10 15 20 ggc gtt cat tac ttg atg aag aag aac aag atc atc gaa att cat ggt 211 Gly Val His Tyr Leu Met Lys Lys Asn Lys Ile Ile Glu Ile His Gly              25 30 35 ctt gga aac ttc aag gat gct aag act ctt gag gtc acc gac ggt aag 259 Leu Gly Asn Phe Lys Asp Ala Lys Thr Leu Glu Val Thr Asp Gly Lys          40 45 50 gat gct ggc aag acc atc acc ttt gat gac tgc atc atc gca acc ggt 307 Asp Ala Gly Lys Thr Ile Thr Phe Asp Asp Cys Ile Ala Thr Gly      55 60 65 tcg gta gtc aac acc ctc cgt ggc gtt gac ttc tca gag aac gtt gtg 355 Ser Val Val Asn Thr Leu Arg Gly Val Asp Phe Ser Glu Asn Val Val  70 75 80 85 tct ttt gaa gag cag att ctt aac cct gtt gcg cca aag aag atg gtc 403 Ser Phe Glu Glu Gln Ile Leu Asn Pro Val Ala Pro Lys Lys Met Val                  90 95 100 att gtt ggt gca ggc gca att gga atg gaa ttc gcc tac gtt ctt ggt 451 Ile Val Gly Ala Gly Ala Ile Gly Met Glu Phe Ala Tyr Val Leu Gly             105 110 115 aac tac ggt gta gat gta acc gtc atc gag ttc atg gat cgt gtg ctt 499 Asn Tyr Gly Val Asp Val Thr Val Ile Glu Phe Met Asp Arg Val Leu         120 125 130 cca aat gaa gat gct gaa gtc tcc aag gtt att gca aag gcc tac aag 547 Pro Asn Glu Asp Ala Glu Val Ser Lys Val Ile Ala Lys Ala Tyr Lys     135 140 145 aag atg ggc gtt aag ctt ctt cct ggc cat gca acc act gct gtt cgg 595 Lys Met Gly Val Lys Leu Leu Pro Gly His Ala Thr Thr Ala Val Arg 150 155 160 165 gac aac ggt gac ttt gtc gag gtt gat tac cag aag aag ggc tct gac 643 Asp Asn Gly Asp Phe Val Glu Val Asp Tyr Gln Lys Lys Gly Ser Asp                 170 175 180 aag aca gag act ctt act gtt gat cga gtc atg gtt tcc gtt ggt ttc 691 Lys Thr Glu Thr Leu Thr Val Asp Arg Val Met Val Ser Val Gly Phe             185 190 195 cgt cca cgc gtt gag gga ttt ggt ctt gaa aac act ggc gtt aag ctc 739 Arg Pro Arg Val Glu Gly Phe Gly Leu Glu Asn Thr Gly Val Lys Leu         200 205 210 acc gag cgt ggc gca atc gag atc gat gat tac atg cgt acc aac gtc 787 Thr Glu Arg Gly Ala Ile Glu Ile Asp Asp Tyr Met Arg Thr Asn Val     215 220 225 gat ggc att tac gcc atc ggt gac gtg acc gcc aag ctt cag ctt gct 835 Asp Gly Ile Tyr Ala Ile Gly Asp Val Thr Ala Lys Leu Gln Leu Ala 230 235 240 245 cac gtc gca gaa gca cag ggc att gtt gcc gca gag act att gct ggt 883 His Val Ala Glu Ala Gln Gly Ile Val Ala Ala Glu Thr Ile Ala Gly                 250 255 260 gca gaa act cag act ctt ggt gat tac atg atg atg cca cgt gca acc 931 Ala Glu Thr Gln Thr Leu Gly Asp Tyr Met Met Met Pro Arg Ala Thr             265 270 275 ttc tgc aac cca cag gtt tct tcc ttt ggt tac acc gaa gag cag gcc 979 Phe Cys Asn Pro Gln Val Ser Ser Phe Gly Tyr Thr Glu Glu Gln Ala         280 285 290 aag gag aag tgg cca gat cgt gag atc aag gtt gct tcc ttc cca ttc 1027 Lys Glu Lys Trp Pro Asp Arg Glu Ile Lys Val Ala Ser Phe Pro Phe     295 300 305 tct gca aac ggt aaa gca gtt ggc ctg gca gaa act gat ggt ttc gca 1075 Ser Ala Asn Gly Lys Ala Val Gly Leu Ala Glu Thr Asp Gly Phe Ala 310 315 320 325 aag atc gtt gct gat gca gaa ttc ggt gag ctg ctc ggt gca cac ctg 1123 Lys Ile Val Ala Asp Ala Glu Phe Gly Glu Leu Leu Gly Ala His Leu                 330 335 340 gtt gga gca aat gca tca gag ctc atc aat gaa ttg gtg ctt gct cag 1171 Val Gly Ala Asn Ala Ser Glu Leu Ile Asn Glu Leu Val Leu Ala Gln             345 350 355 aac tgg gat ctc acc act gaa gag atc tct cgt agc gtc cat att cac 1219 Asn Trp Asp Leu Thr Thr Glu Glu Ile Ser Arg Ser Val His Ile His         360 365 370 cca acg cta tct gag gca gtt aag gaa gct gca cac ggt atc tct gga 1267 Pro Thr Leu Ser Glu Ala Val Lys Glu Ala Ala His Gly Ile Ser Gly     375 380 385 cac atg atc aac ttc tagaatccac ctcgttggcc ctg 1305 His Met Ile Asn Phe 390 <210> 224 <211> 394 <212> PRT <213> Corynebacterium glutamicum <400> 224 Val Thr Phe Asn Tyr Glu Asp Ala His Lys Arg Ser Arg Gly Val Ser   1 5 10 15 Asp Lys Ile Val Gly Gly Val His Tyr Leu Met Lys Lys Asn Lys Ile              20 25 30 Ile Glu Ile His Gly Leu Gly Asn Phe Lys Asp Ala Lys Thr Leu Glu          35 40 45 Val Thr Asp Gly Lys Asp Ala Gly Lys Thr Ile Thr Phe Asp Asp Cys      50 55 60 Ile Ile Ala Thr Gly Ser Val Val Asn Thr Leu Arg Gly Val Asp Phe  65 70 75 80 Ser Glu Asn Val Val Ser Phe Glu Glu Gln Ile Leu Asn Pro Val Ala                  85 90 95 Pro Lys Lys Met Val Ile Val Gly Ala Gly Ala Ile Gly Met Glu Phe             100 105 110 Ala Tyr Val Leu Gly Asn Tyr Gly Val Asp Val Thr Val Ile Glu Phe         115 120 125 Met Asp Arg Val Leu Pro Asn Glu Asp Ala Glu Val Ser Lys Val Ile     130 135 140 Ala Lys Ala Tyr Lys Lys Met Gly Val Lys Leu Leu Pro Gly His Ala 145 150 155 160 Thr Thr Ala Val Arg Asp Asn Gly Asp Phe Val Glu Val Asp Tyr Gln                 165 170 175 Lys Lys Gly Ser Asp Lys Thr Glu Thr Leu Thr Val Asp Arg Val Met             180 185 190 Val Ser Val Gly Phe Arg Pro Arg Val Glu Gly Phe Gly Leu Glu Asn         195 200 205 Thr Gly Val Lys Leu Thr Glu Arg Gly Ala Ile Glu Ile Asp Asp Tyr     210 215 220 Met Arg Thr Asn Val Asp Gly Ile Tyr Ala Ile Gly Asp Val Thr Ala 225 230 235 240 Lys Leu Gln Leu Ala His Val Ala Glu Ala Gln Gly Ile Val Ala Ala                 245 250 255 Glu Thr Ile Ala Gly Ala Glu Thr Gln Thr Leu Gly Asp Tyr Met Met             260 265 270 Met Pro Arg Ala Thr Phe Cys Asn Pro Gln Val Ser Ser Phe Gly Tyr         275 280 285 Thr Glu Glu Gln Ala Lys Glu Lys Trp Pro Asp Arg Glu Ile Lys Val     290 295 300 Ala Ser Phe Pro Phe Ser Ala Asn Gly Lys Ala Val Gly Leu Ala Glu 305 310 315 320 Thr Asp Gly Phe Ala Lys Ile Val Ala Asp Ala Glu Phe Gly Glu Leu                 325 330 335 Leu Gly Ala His Leu Val Gly Ala Asn Ala Ser Glu Leu Ile Asn Glu             340 345 350 Leu Val Leu Ala Gln Asn Trp Asp Leu Thr Thr Glu Glu Ile Ser Arg         355 360 365 Ser Val His Ile His Pro Thr Leu Ser Glu Ala Val Lys Glu Ala Ala     370 375 380 His Gly Ile Ser Gly His Met Ile Asn Phe 385 390 <210> 225 <211> 294 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (271) <223> RXA01261 <400> 225 gtgggtgttt ttcattttct tccactctaa aattaagtat ggaaaaccaa ccgcacccgg 60 atgcacgaca atgacccact aaacacgtat ccttgaatgc gtg act gaa cat tat 115                                             Val Thr Glu His Tyr                                               1 5 gac gta gta gta ctc gga gcc ggc ccc ggt ggc tat gtc tcc gcc atc 163 Asp Val Val Val Leu Gly Ala Gly Pro Gly Gly Tyr Val Ser Ala Ile                  10 15 20 cgt gca gcg cag ctt ggc aag aag gtt gct gta att gag aag cag tac 211 Arg Ala Ala Gln Leu Gly Lys Lys Val Ala Val Ile Glu Lys Gln Tyr              25 30 35 tgg ggt ggt gtt tgc cta aac gtg ggc tgc att cct tcc aaa gtc tct 259 Trp Gly Gly Val Cys Leu Asn Val Gly Cys Ile Pro Ser Lys Val Ser          40 45 50 gat caa aaa cgc tgaagttgcc cataccttta ccc 294 Asp Gln Lys Arg      55 <210> 226 <211> 57 <212> PRT <213> Corynebacterium glutamicum <400> 226 Val Thr Glu His Tyr Asp Val Val Val Leu Gly Ala Gly Pro Gly Gly   1 5 10 15 Tyr Val Ser Ala Ile Arg Ala Ala Gln Leu Gly Lys Lys Val Ala Val              20 25 30 Ile Glu Lys Gln Tyr Trp Gly Gly Val Cys Leu Asn Val Gly Cys Ile          35 40 45 Pro Ser Lys Val Ser Asp Gln Lys Arg      50 55 <210> 227 <211> 555 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (532) <223> RXA01136 <400> 227 ccctcgcaac accgacggta gcctcttgga aatggcgcgc atcgtgcgtg agctttcccg 60 ctaggacctg tctactgcct tcactttgtg cgaacaccgc atg acc ttg gat tac 115                                             Met Thr Leu Asp Tyr                                               1 5 ttc aag gca tcc ggc act gac tat gct ttg gga ttg gct gca gag tcg 163 Phe Lys Ala Ser Gly Thr Asp Tyr Ala Leu Gly Leu Ala Ala Glu Ser                  10 15 20 gaa ggg gca cga cgc act ggt atc acc ggc atg gcg agt gca ttc aag 211 Glu Gly Ala Arg Arg Thr Gly Ile Thr Gly Met Ala Ser Ala Phe Lys              25 30 35 gag ttt gct ggt tgt ggt gag atc gac ctt gaa gca acc agg gta gaa 259 Glu Phe Ala Gly Cys Gly Glu Ile Asp Leu Glu Ala Thr Arg Val Glu          40 45 50 ggt ggc ctc aaa gtt agt gga aag ctt cgt tgg gct tcc aac ttg tgc 307 Gly Gly Leu Lys Val Ser Gly Lys Leu Arg Trp Ala Ser Asn Leu Cys      55 60 65 gaa gat cca gtg att gtg cct gct gca aag acc gca gag ggc tta caa 355 Glu Asp Pro Val Ile Val Pro Ala Ala Lys Thr Ala Glu Gly Leu Gln  70 75 80 85 cta ctg ttc gca ttg ggc gca gaa acc gaa ggt gtc acc ctc ggt tct 403 Leu Leu Phe Ala Leu Gly Ala Glu Thr Glu Gly Val Thr Leu Gly Ser                  90 95 100 tca ctt gct cta ctc ggt ttg aac gca act gct tgc gct tgg gtg agc 451 Ser Leu Ala Leu Leu Gly Leu Asn Ala Thr Ala Cys Ala Trp Val Ser             105 110 115 ttt gag gat gtc ttc att cct ggg gct cag att cta agc cac gat ttc 499 Phe Glu Asp Val Phe Ile Pro Gly Ala Gln Ile Leu Ser His Asp Phe         120 125 130 ctt acc ttg tgg cat cgg tgc gcc caa cct tcg tgatcctacg gatctccgaa 552 Leu Thr Leu Trp His Arg Cys Ala Gln Pro Ser     135 140 tac 555 <210> 228 <211> 144 <212> PRT <213> Corynebacterium glutamicum <400> 228 Met Thr Leu Asp Tyr Phe Lys Ala Ser Gly Thr Asp Tyr Ala Leu Gly   1 5 10 15 Leu Ala Ala Glu Ser Glu Gly Ala Arg Arg Thr Gly Ile Thr Gly Met              20 25 30 Ala Ser Ala Phe Lys Glu Phe Ala Gly Cys Gly Glu Ile Asp Leu Glu          35 40 45 Ala Thr Arg Val Glu Gly Gly Leu Lys Val Ser Gly Lys Leu Arg Trp      50 55 60 Ala Ser Asn Leu Cys Glu Asp Pro Val Ile Val Pro Ala Ala Lys Thr  65 70 75 80 Ala Glu Gly Leu Gln Leu Leu Phe Ala Leu Gly Ala Glu Thr Glu Gly                  85 90 95 Val Thr Leu Gly Ser Ser Leu Ala Leu Leu Gly Leu Asn Ala Thr Ala             100 105 110 Cys Ala Trp Val Ser Phe Glu Asp Val Phe Ile Pro Gly Ala Gln Ile         115 120 125 Leu Ser His Asp Phe Leu Thr Leu Trp His Arg Cys Ala Gln Pro Ser     130 135 140 <210> 229 <211> 1140 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1117) <223> RXN00559 <400> 229 cccttcaatc cagtctttga cggccaatac ggcttgccgg gtttccagcg gatcaatcct 60 catgaagcat cagcctagta cgaaccgtta aagtgtccat atg tct gat aat ccg 115                                             Met Ser Asp Asn Pro                                               1 5 cat gag aat ccc cgt gag aat cca cac cgc tcc cca gaa gtc gtc ctt 163 His Glu Asn Pro Arg Glu Asn Pro His Arg Ser Pro Glu Val Val Leu                  10 15 20 cgt ttc atg gct gcc cct act gac gtt ttg atg gct ggt agc cat ggc 211 Arg Phe Met Ala Ala Pro Thr Asp Val Leu Met Ala Gly Ser His Gly              25 30 35 gtt ggc ggt ggc cga gtc ctg gaa tgg atc gat aag gct gct tat gct 259 Val Gly Gly Gly Arg Val Leu Glu Trp Ile Asp Lys Ala Ala Tyr Ala          40 45 50 tgt gct acc cag tgg tct gga acc tac tgt gtc act gct tat gtt ggt 307 Cys Ala Thr Gln Trp Ser Gly Thr Tyr Cys Val Thr Ala Tyr Val Gly      55 60 65 cac att cac ttc act cgc cct att ccc tct ggc cac atg gtc gag gtg 355 His Ile His Phe Thr Arg Pro Ile Pro Ser Gly His Met Val Glu Val  70 75 80 85 cgt tcc cgc att gcg atg act ggc cgt tcc tcc atg cac atc gtg aat 403 Arg Ser Arg Ile Ala Met Thr Gly Arg Ser Ser Met His Ile Val Asn                  90 95 100 gag gtg ctt tct gcg gat cct cgc gat ggc aac tac acc cgt gcg tgt 451 Glu Val Leu Ser Ala Asp Pro Arg Asp Gly Asn Tyr Thr Arg Ala Cys             105 110 115 gac tgc ttg gtt att ttc gtg gcg aag gac acc gca act ggt cgc gct 499 Asp Cys Leu Val Ile Phe Val Ala Lys Asp Thr Ala Thr Gly Arg Ala         120 125 130 acc cca gtt cct tca ttt acc cct aag aat gaa gaa gag cag cgc gtg 547 Thr Pro Val Pro Ser Phe Thr Pro Lys Asn Glu Glu Glu Gln Arg Val     135 140 145 ttg gaa gct gct aac tcc cgc atc ggg ctg cgc aag gct att gaa gcg 595 Leu Glu Ala Ala Asn Ser Arg Ile Gly Leu Arg Lys Ala Ile Glu Ala 150 155 160 165 gag atg gaa aag cag acg tac aac gga cct tct gag gcc cct cgt ttg 643 Glu Met Glu Lys Gln Thr Tyr Asn Gly Pro Ser Glu Ala Pro Arg Leu                 170 175 180 att acc cgc ttc ttg gct aag cca aca gat atc aac tgg ggt ggc aag 691 Ile Thr Arg Phe Leu Ala Lys Pro Thr Asp Ile Asn Trp Gly Gly Lys             185 190 195 gtc cac ggt ggc act gcc atg gaa tgg atc gat gag gcg ggt gct gcg 739 Val His Gly Gly Thr Ala Met Glu Trp Ile Asp Glu Ala Gly Ala Ala         200 205 210 tgc acc atg gag tgg tct ggt aac cac acc gtt gcg gtt tat gct ggt 787 Cys Thr Met Glu Trp Ser Gly Asn His Thr Val Ala Val Tyr Ala Gly     215 220 225 ggt atc cgc ttc tac cag ccc att cag atc ggt gac ctc att gag gtg 835 Gly Ile Arg Phe Tyr Gln Pro Ile Gln Ile Gly Asp Leu Ile Glu Val 230 235 240 245 gac gcc cgc atg atg cgt acc gat aag cgt tcc atg cag atg tcc atc 883 Asp Ala Arg Met Met Arg Thr Asp Lys Arg Ser Met Gln Met Ser Ile                 250 255 260 cac gtc cgt gcc ggt gat gct cac cgt ggc cgt gct gag cta gaa acc 931 His Val Arg Ala Gly Asp Ala His Arg Gly Arg Ala Glu Leu Glu Thr             265 270 275 gct att cac gca acg gtg acc tac tta gga att gat gtc gac gga gag 979 Ala Ile His Ala Thr Val Thr Tyr Leu Gly Ile Asp Val Asp Gly Glu         280 285 290 cct ttg cct gca cca cag ttt gtg cct cgt acc cct gag gat atc cag 1027 Pro Leu Pro Ala Pro Gln Phe Val Pro Arg Thr Pro Glu Asp Ile Gln     295 300 305 ttg gct gag cat gca aac atc ctg agg gat ctg cgt gct gat tac acc 1075 Leu Ala Glu His Ala Asn Ile Leu Arg Asp Leu Arg Ala Asp Tyr Thr 310 315 320 325 cca atg ccg ctg ttc cag cgc agg gtt cca ctg cag atc gac 1117 Pro Met Pro Leu Phe Gln Arg Arg Val Pro Leu Gln Ile Asp                 330 335 tagttagacc cgaaaaagcc ccc 1140 <210> 230 <211> 339 <212> PRT <213> Corynebacterium glutamicum <400> 230 Met Ser Asp Asn Pro His Glu Asn Pro Arg Glu Asn Pro His Arg Ser   1 5 10 15 Pro Glu Val Val Leu Arg Phe Met Ala Ala Pro Thr Asp Val Leu Met              20 25 30 Ala Gly Ser His Gly Val Gly Gly Gly Arg Val Leu Glu Trp Ile Asp          35 40 45 Lys Ala Ala Tyr Ala Cys Ala Thr Gln Trp Ser Gly Thr Tyr Cys Val      50 55 60 Thr Ala Tyr Val Gly His Ile His Phe Thr Arg Pro Ile Pro Ser Gly  65 70 75 80 His Met Val Glu Val Arg Ser Arg Ile Ala Met Thr Gly Arg Ser Ser                  85 90 95 Met His Ile Val Asn Glu Val Leu Ser Ala Asp Pro Arg Asp Gly Asn             100 105 110 Tyr Thr Arg Ala Cys Asp Cys Leu Val Ile Phe Val Ala Lys Asp Thr         115 120 125 Ala Thr Gly Arg Ala Thr Pro Val Pro Ser Phe Thr Pro Lys Asn Glu     130 135 140 Glu Glu Gln Arg Val Leu Glu Ala Ala Asn Ser Arg Ile Gly Leu Arg 145 150 155 160 Lys Ala Ile Glu Ala Glu Met Glu Lys Gln Thr Tyr Asn Gly Pro Ser                 165 170 175 Glu Ala Pro Arg Leu Ile Thr Arg Phe Leu Ala Lys Pro Thr Asp Ile             180 185 190 Asn Trp Gly Gly Lys Val His Gly Gly Thr Ala Met Glu Trp Ile Asp         195 200 205 Glu Ala Gly Ala Ala Cys Thr Met Glu Trp Ser Gly Asn His Thr Val     210 215 220 Ala Val Tyr Ala Gly Gly Ile Arg Phe Tyr Gln Pro Ile Gln Ile Gly 225 230 235 240 Asp Leu Ile Glu Val Asp Ala Arg Met Met Arg Thr Asp Lys Arg Ser                 245 250 255 Met Gln Met Ser Ile His Val Arg Ala Gly Asp Ala His Arg Gly Arg             260 265 270 Ala Glu Leu Glu Thr Ala Ile His Ala Thr Val Thr Tyr Leu Gly Ile         275 280 285 Asp Val Asp Gly Glu Pro Leu Pro Ala Pro Gln Phe Val Pro Arg Thr     290 295 300 Pro Glu Asp Ile Gln Leu Ala Glu His Ala Asn Ile Leu Arg Asp Leu 305 310 315 320 Arg Ala Asp Tyr Thr Pro Met Pro Leu Phe Gln Arg Arg Val Pro Leu                 325 330 335 Gln ile asp <210> 231 <211> 313 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (313) <223> FRXA00559 <400> 231 cccttcaatc cagtctttga cggccaatac ggcttgccgg gtttccagcg gatcaatcct 60 catgaagcat cagcctagta cgaaccgtta aagtgtccat atg tct gat aat ccg 115                                             Met Ser Asp Asn Pro                                               1 5 cat gag aat ccc cgt gag aat cca cac cgc tcc cca gaa gtc gtc ctt 163 His Glu Asn Pro Arg Glu Asn Pro His Arg Ser Pro Glu Val Val Leu                  10 15 20 cgt ttc atg gct gcc cct act gac gtt ttg atg gct ggt agc cat ggc 211 Arg Phe Met Ala Ala Pro Thr Asp Val Leu Met Ala Gly Ser His Gly              25 30 35 gtt ggc ggt ggc cga gtc ctg gaa tgg atc gat aag gct gct tat gct 259 Val Gly Gly Gly Arg Val Leu Glu Trp Ile Asp Lys Ala Ala Tyr Ala          40 45 50 tgt gct acc cac ggg tct gga acc tac tgc gtc act gct tat gtt ggt 307 Cys Ala Thr His Gly Ser Gly Thr Tyr Cys Val Thr Ala Tyr Val Gly      55 60 65 cac att 313 His ile  70 <210> 232 <211> 71 <212> PRT <213> Corynebacterium glutamicum <400> 232 Met Ser Asp Asn Pro His Glu Asn Pro Arg Glu Asn Pro His Arg Ser   1 5 10 15 Pro Glu Val Val Leu Arg Phe Met Ala Ala Pro Thr Asp Val Leu Met              20 25 30 Ala Gly Ser His Gly Val Gly Gly Gly Arg Val Leu Glu Trp Ile Asp          35 40 45 Lys Ala Ala Tyr Ala Cys Ala Thr His Gly Ser Gly Thr Tyr Cys Val      50 55 60 Thr Ala Tyr Val Gly His Ile  65 70 <210> 233 <211> 802 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (802) <223> RXA01580 <400> 233 cggtaaacgc ctcattaaag tccaatgcca tgctcataac actaacagtt aaccgtgcgg 60 tcaactttgc tccctatcct taaaaagccc acagaaaagg atg tat aag aat atg 115                                             Met Tyr Lys Asn Met                                               1 5 cac att gtt gcc cat cgc ggt gcg gaa gat ctg cac ctc gaa aac acc 163 His Ile Val Ala His Arg Gly Ala Glu Asp Leu His Leu Glu Asn Thr                  10 15 20 atg acc gct ttc cag gct gcc gcg ccc gct gac gct ttt gag ctg gat 211 Met Thr Ala Phe Gln Ala Ala Ala Pro Ala Asp Ala Phe Glu Leu Asp              25 30 35 atc cac gcc acc gct gac aat cag gtc gtc gtt atc cac gac cgc acc 259 Ile His Ala Thr Ala Asp Asn Gln Val Val Val Ile His Asp Arg Thr          40 45 50 gca gcg cgt gtt gcc gcg cca gat tcc ctg cac cgc gac acc ccg gtt 307 Ala Ala Arg Val Ala Ala Pro Asp Ser Leu His Arg Asp Thr Pro Val      55 60 65 gcg cgc tta agc gcc gcg caa atc aag gag ata acg ctt atc gac gga 355 Ala Arg Leu Ser Ala Ala Gln Ile Lys Glu Ile Thr Leu Ile Asp Gly  70 75 80 85 tcc ccc gta cca acc ctg gag gaa gtt cta ctc cag acg agc ctg ccg 403 Ser Pro Val Pro Thr Leu Glu Glu Val Leu Leu Gln Thr Ser Leu Pro                  90 95 100 atc caa gtg gaa atc aaa tct gcc ggt gca gtt cca gca gcc gca gca 451 Ile Gln Val Glu Ile Lys Ser Ala Gly Ala Val Pro Ala Ala Ala Ala             105 110 115 tta ttg cag aaa tac cca gag cac ctg gag cgc ctg ctg ttc atc agt 499 Leu Leu Gln Lys Tyr Pro Glu His Leu Glu Arg Leu Leu Phe Ile Ser         120 125 130 ttc atc gat gca gca ctg gtg gaa atc gtg gat cga ctg cca gaa gct 547 Phe Ile Asp Ala Ala Leu Val Glu Ile Val Asp Arg Leu Pro Glu Ala     135 140 145 cgc gtg gga atc ttg cgc gat gcg tcc atg gat gat ctg cgc att ctt 595 Arg Val Gly Ile Leu Arg Asp Ala Ser Met Asp Asp Leu Arg Ile Leu 150 155 160 165 gat tac atc ccg cta aaa aat gtg ggc gcg atc ttg ccc tcg tgg aaa 643 Asp Tyr Ile Pro Leu Lys Asn Val Gly Ala Ile Leu Pro Ser Trp Lys                 170 175 180 gca cta aac gtg gcg tca att gct gat cta cat acc aag gga atc aag 691 Ala Leu Asn Val Ala Ser Ile Ala Asp Leu His Thr Lys Gly Ile Lys             185 190 195 gtt ggc tgc tgg aca att cgg gat gaa aat gcg ttt ggg atc gca caa 739 Val Gly Cys Trp Thr Ile Arg Asp Glu Asn Ala Phe Gly Ile Ala Gln         200 205 210 caa gct ggc gtt gat tac ccc act gtt agc gat ccc tct cgt ttc tcg 787 Gln Ala Gly Val Asp Tyr Pro Thr Val Ser Asp Pro Ser Arg Phe Ser     215 220 225 cgc cct ccc ctg ctg 802 Arg Pro Pro Leu Leu 230 <210> 234 <211> 234 <212> PRT <213> Corynebacterium glutamicum <400> 234 Met Tyr Lys Asn Met His Ile Val Ala His Arg Gly Ala Glu Asp Leu   1 5 10 15 His Leu Glu Asn Thr Met Thr Ala Phe Gln Ala Ala Ala Pro Ala Asp              20 25 30 Ala Phe Glu Leu Asp Ile His Ala Thr Ala Asp Asn Gln Val Val Val          35 40 45 Ile His Asp Arg Thr Ala Ala Arg Val Ala Ala Pro Asp Ser Leu His      50 55 60 Arg Asp Thr Pro Val Ala Arg Leu Ser Ala Ala Gln Ile Lys Glu Ile  65 70 75 80 Thr Leu Ile Asp Gly Ser Pro Val Pro Thr Leu Glu Glu Val Leu Leu                  85 90 95 Gln Thr Ser Leu Pro Ile Gln Val Glu Ile Lys Ser Ala Gly Ala Val             100 105 110 Pro Ala Ala Ala Ala Leu Leu Gln Lys Tyr Pro Glu His Leu Glu Arg         115 120 125 Leu Leu Phe Ile Ser Phe Ile Asp Ala Ala Leu Val Glu Ile Val Asp     130 135 140 Arg Leu Pro Glu Ala Arg Val Gly Ile Leu Arg Asp Ala Ser Met Asp 145 150 155 160 Asp Leu Arg Ile Leu Asp Tyr Ile Pro Leu Lys Asn Val Gly Ala Ile                 165 170 175 Leu Pro Ser Trp Lys Ala Leu Asn Val Ala Ser Ile Ala Asp Leu His             180 185 190 Thr Lys Gly Ile Lys Val Gly Cys Trp Thr Ile Arg Asp Glu Asn Ala         195 200 205 Phe Gly Ile Ala Gln Gln Ala Gly Val Asp Tyr Pro Thr Val Ser Asp     210 215 220 Pro Ser Arg Phe Ser Arg Pro Pro Leu Leu 225 230 <210> 235 <211> 882 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (859) <223> RXA02677 <400> 235 ttagtgcagt gtatttattt ccgttcacgc tgcggggctg gtggtttgga gggatactag 60 agtcgatagc aggtatataa aggccaggag agatgggttc atg aaa gtc atc gcg 115                                             Met Lys Val Ile Ala                                               1 5 cac cga ggt tta tcg tct cgc ttt ccc gaa tta aca gag tct gcg ttt 163 His Arg Gly Leu Ser Ser Arg Phe Pro Glu Leu Thr Glu Ser Ala Phe                  10 15 20 cgg gcg gct cta gag cta ccg att cat gga att gaa act gat gtc cgg 211 Arg Ala Ala Leu Glu Leu Pro Ile His Gly Ile Glu Thr Asp Val Arg              25 30 35 ctg act aaa tgt ggc gaa gtg gtt aac gtc cat gac ccc att gtg gat 259 Leu Thr Lys Cys Gly Glu Val Val Asn Val His Asp Pro Ile Val Asp          40 45 50 cgc gtg tcg aat ggt cgc ggt cgg gtg tcg cgt ttg gac ttg gaa tcc 307 Arg Val Ser Asn Gly Arg Gly Arg Val Ser Arg Leu Asp Leu Glu Ser      55 60 65 ttg ctg agc ttg aac ttt gga acc aaa gaa acc cca gaa aaa gtg ctt 355 Leu Leu Ser Leu Asn Phe Gly Thr Lys Glu Thr Pro Glu Lys Val Leu  70 75 80 85 act tta aac aat cta tta gat att ttt gag gat tat cca gat aag cac 403 Thr Leu Asn Asn Leu Leu Asp Ile Phe Glu Asp Tyr Pro Asp Lys His                  90 95 100 ctt tat ata gaa acc aag cac cca atg cgc tac gcg gtc atg ctg gaa 451 Leu Tyr Ile Glu Thr Lys His Pro Met Arg Tyr Ala Val Met Leu Glu             105 110 115 gaa gaa atc aca aaa atc tta aaa tat cgt ggg ctg acg gaa gac cca 499 Glu Glu Ile Thr Lys Ile Leu Lys Tyr Arg Gly Leu Thr Glu Asp Pro         120 125 130 cgc atc cac atc att tct ttt gca ctt ccc gcg atg tat cgc atg gct 547 Arg Ile His Ile Ile Ser Phe Ala Leu Pro Ala Met Tyr Arg Met Ala     135 140 145 cgc ctt gct cca cag ctt gat cgc att cat ctg cgc agg tcg tgg gag 595 Arg Leu Ala Pro Gln Leu Asp Arg Ile His Leu Arg Arg Ser Trp Glu 150 155 160 165 cgt tgg ggt aat ccg cgc gat gtg cgc tgc ggt gta ccc acc ggt ttg 643 Arg Trp Gly Asn Pro Arg Asp Val Arg Cys Gly Val Pro Thr Gly Leu                 170 175 180 ggg ttg tcg ctg gag cgg gcg aag atg gat cca agg atg att ggg gcg 691 Gly Leu Ser Leu Glu Arg Ala Lys Met Asp Pro Arg Met Ile Gly Ala             185 190 195 aaa ggg tta ccc acc tat ctt ttc acc gtc gat aag caa aaa gac atg 739 Lys Gly Leu Pro Thr Tyr Leu Phe Thr Val Asp Lys Gln Lys Asp Met         200 205 210 ctg tgg gcg cgc gaa cag ggc gtc gac atg ctc gcc acc aat tat ccg 787 Leu Trp Ala Arg Glu Gln Gly Val Asp Met Leu Ala Thr Asn Tyr Pro     215 220 225 gac cgt gcg gcg gag ctt ttg aac gca cat ccc aag ccc gcc atg tac 835 Asp Arg Ala Ala Glu Leu Leu Asn Ala His Pro Lys Pro Ala Met Tyr 230 235 240 245 gct aat gcg cat ggc aaa gaa gac taagaagaat gaacagctgc cgg 882 Ala Asn Ala His Gly Lys Glu Asp                 250 <210> 236 <211> 253 <212> PRT <213> Corynebacterium glutamicum <400> 236 Met Lys Val Ile Ala His Arg Gly Leu Ser Ser Arg Phe Pro Glu Leu   1 5 10 15 Thr Glu Ser Ala Phe Arg Ala Ala Leu Glu Leu Pro Ile His Gly Ile              20 25 30 Glu Thr Asp Val Arg Leu Thr Lys Cys Gly Glu Val Val Asn Val His          35 40 45 Asp Pro Ile Val Asp Arg Val Ser Asn Gly Arg Gly Arg Val Ser Arg      50 55 60 Leu Asp Leu Glu Ser Leu Leu Ser Leu Asn Phe Gly Thr Lys Glu Thr  65 70 75 80 Pro Glu Lys Val Leu Thr Leu Asn Asn Leu Leu Asp Ile Phe Glu Asp                  85 90 95 Tyr Pro Asp Lys His Leu Tyr Ile Glu Thr Lys His Pro Met Arg Tyr             100 105 110 Ala Val Met Leu Glu Glu Glu Ile Thr Lys Ile Leu Lys Tyr Arg Gly         115 120 125 Leu Thr Glu Asp Pro Arg Ile His Ile Ile Ser Phe Ala Leu Pro Ala     130 135 140 Met Tyr Arg Met Ala Arg Leu Ala Pro Gln Leu Asp Arg Ile His Leu 145 150 155 160 Arg Arg Ser Trp Glu Arg Trp Gly Asn Pro Arg Asp Val Arg Cys Gly                 165 170 175 Val Pro Thr Gly Leu Gly Leu Ser Leu Glu Arg Ala Lys Met Asp Pro             180 185 190 Arg Met Ile Gly Ala Lys Gly Leu Pro Thr Tyr Leu Phe Thr Val Asp         195 200 205 Lys Gln Lys Asp Met Leu Trp Ala Arg Glu Gln Gly Val Asp Met Leu     210 215 220 Ala Thr Asn Tyr Pro Asp Arg Ala Ala Glu Leu Leu Asn Ala His Pro 225 230 235 240 Lys Pro Ala Met Tyr Ala Asn Ala His Gly Lys Glu Asp                 245 250 <210> 237 <211> 1428 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1405) <223> RXS01166 <400> 237 accgtaccca cagacacacc agaattaaca gaaacagact gaaaaacaac atcgctcgac 60 atgcgcgtaa tcctaacccg cgcacactaa tgtggccgat atg ggc tac acc aac 115                                             Met Gly Tyr Thr Asn                                               1 5 ctc aac gac aca cgg gtc ttg cgc gcc ggg tca tgt gat gcc tgg tgg 163 Leu Asn Asp Thr Arg Val Leu Arg Ala Gly Ser Cys Asp Ala Trp Trp                  10 15 20 cgc acg atg tct ccg cta gtg cag cag gga agt gag gca gtc ttt cgg 211 Arg Thr Met Ser Pro Leu Val Gln Gln Gly Ser Glu Ala Val Phe Arg              25 30 35 cgc atc atg ggt ctc tcg cgg cgt cct gat cgg aaa cct ggc ttt gac 259 Arg Ile Met Gly Leu Ser Arg Arg Pro Asp Arg Lys Pro Gly Phe Asp          40 45 50 gat gtc cca cat ttc ggc gca gct gtt cga gtt ccc ggt cta aaa cac 307 Asp Val Pro His Phe Gly Ala Ala Val Arg Val Pro Gly Leu Lys His      55 60 65 ggc acg ttg gtc aat gct gca ccc ttg aaa gtt ttg ggc gca cgg ggc 355 Gly Thr Leu Val Asn Ala Ala Pro Leu Lys Val Leu Gly Ala Arg Gly  70 75 80 85 gag ccc aac ccc gcg agt tcg tac cgt ttt gaa tac atc acc ggt gat 403 Glu Pro Asn Pro Ala Ser Ser Tyr Arg Phe Glu Tyr Ile Thr Gly Asp                  90 95 100 tcc gca ggt cga gcc atc act gcg acc ggc gct gtc ctc ttt tcc aca 451 Ser Ala Gly Arg Ala Ile Thr Ala Thr Gly Ala Val Leu Phe Ser Thr             105 110 115 cgc ccc tgg aca acc ggc ccg cgt ccc gcg atc gcc atg gct cca tcc 499 Arg Pro Trp Thr Thr Gly Pro Arg Pro Ala Ile Ala Met Ala Pro Ser         120 125 130 acc caa ggc gtc gca cag cac tgc gat ccc tcc cac acc tgc gcc atc 547 Thr Gln Gly Val Ala Gln His Cys Asp Pro Ser His Thr Cys Ala Ile     135 140 145 gga ctc aac gca ttc tat gac aaa ccc ttc gac gca atc att gct tac 595 Gly Leu Asn Ala Phe Tyr Asp Lys Pro Phe Asp Ala Ile Ile Ala Tyr 150 155 160 165 gaa ctc ccc gtc atc ctc tgg ttt cta gct cac gga ctt gac gtt gtg 643 Glu Leu Pro Val Ile Leu Trp Phe Leu Ala His Gly Leu Asp Val Val                 170 175 180 ttc atc gat tac ccc cgc gac ccc gca acc ggc gtc caa tac tat tgc 691 Phe Ile Asp Tyr Pro Arg Asp Pro Ala Thr Gly Val Gln Tyr Tyr Cys             185 190 195 gat tcc atc gct gca gct aaa tcg ctt ctc gac gcc gtc ctc gcc tcc 739 Asp Ser Ile Ala Ala Ala Lys Ser Leu Leu Asp Ala Val Leu Ala Ser         200 205 210 aga caa ctc ggc ctt tca ccg gaa gca ccg ctt ggc ctg tgg gga ttc 787 Arg Gln Leu Gly Leu Ser Pro Glu Ala Pro Leu Gly Leu Trp Gly Phe     215 220 225 tcc caa gga ggc ggc gcc act ggc tgg gct gca caa ttg cag gat tac 835 Ser Gln Gly Gly Gly Ala Thr Gly Trp Ala Ala Gln Leu Gln Asp Tyr 230 235 240 245 gca cct gat gtc cgc cca aag gca gcg gtc gtg ggc gct cca cca gtg 883 Ala Pro Asp Val Arg Pro Lys Ala Ala Val Val Gly Ala Pro Pro Val                 250 255 260 gat ctc ttc cgc gtc ttg gac act gtc gac ggc gga ttg ctc acc gga 931 Asp Leu Phe Arg Val Leu Asp Thr Val Asp Gly Gly Leu Leu Thr Gly             265 270 275 gtg att gcc tac gcc atc gcg gga ctt gca gtg aac tct tca gag atg 979 Val Ile Ala Tyr Ala Ile Ala Gly Leu Ala Val Asn Ser Ser Glu Met         280 285 290 ttt gag gaa atc atg tcg gtg tta aat gaa cgc gga gtc agt gat gtg 1027 Phe Glu Glu Ile Met Ser Val Leu Asn Glu Arg Gly Val Ser Asp Val     295 300 305 ctg aaa aat atc acc agc tgc gcg gga ggt tcc ttg ttg gcc agt ggc 1075 Leu Lys Asn Ile Thr Ser Cys Ala Gly Ser Leu Leu Ala Ser Gly 310 315 320 325 tac tcg tct tcc cgc ggg tgg aca cat cag ggc acg ccg ctg gca gac 1123 Tyr Ser Ser Ser Arg Gly Trp Thr His Gln Gly Thr Pro Leu Ala Asp                 330 335 340 att ctg gac gat ctg cca ctt gtt gtc gct gag ttt ggg aag caa aag 1171 Ile Leu Asp Asp Leu Pro Leu Val Val Ala Glu Phe Gly Lys Gln Lys             345 350 355 ctg ggt cgt gtg gcg cca gaa atc cca gtg ctg ttg tgg ggc tct aaa 1219 Leu Gly Arg Val Ala Pro Glu Ile Pro Val Leu Leu Trp Gly Ser Lys         360 365 370 aat gat gat gtc att ccc att gat ccc att agg gaa ttg cgt gat agc 1267 Asn Asp Asp Val Ile Pro Ile Asp Pro Ile Arg Glu Leu Arg Asp Ser     375 380 385 tgg gcg gac aag ggt acg cca ttg acc tgg cat gaa tcc caa gcg ccg 1315 Trp Ala Asp Lys Gly Thr Pro Leu Thr Trp His Glu Ser Gln Ala Pro 390 395 400 405 cgt gtg cca gga cgc aca ggt ctc aac cat ttc ggg ccc tat ttt aga 1363 Arg Val Pro Gly Arg Thr Gly Leu Asn His Phe Gly Pro Tyr Phe Arg                 410 415 420 aac ctg gaa aag tac tcg gga tgg ctc ata gat cat ctt gtc 1405 Asn Leu Glu Lys Tyr Ser Gly Trp Leu Ile Asp His Leu Val             425 430 435 tgagtgccgt tttaaaggct cgg 1428 <210> 238 <211> 435 <212> PRT <213> Corynebacterium glutamicum <400> 238 Met Gly Tyr Thr Asn Leu Asn Asp Thr Arg Val Leu Arg Ala Gly Ser   1 5 10 15 Cys Asp Ala Trp Trp Arg Thr Met Ser Pro Leu Val Gln Gln Gly Ser              20 25 30 Glu Ala Val Phe Arg Arg Ile Met Gly Leu Ser Arg Arg Pro Asp Arg          35 40 45 Lys Pro Gly Phe Asp Asp Val Pro His Phe Gly Ala Ala Val Arg Val      50 55 60 Pro Gly Leu Lys His Gly Thr Leu Val Asn Ala Ala Pro Leu Lys Val  65 70 75 80 Leu Gly Ala Arg Gly Glu Pro Asn Pro Ala Ser Ser Tyr Arg Phe Glu                  85 90 95 Tyr Ile Thr Gly Asp Ser Ala Gly Arg Ala Ile Thr Ala Thr Gly Ala             100 105 110 Val Leu Phe Ser Thr Arg Pro Trp Thr Thr Gly Pro Arg Pro Ala Ile         115 120 125 Ala Met Ala Pro Ser Thr Gln Gly Val Ala Gln His Cys Asp Pro Ser     130 135 140 His Thr Cys Ala Ile Gly Leu Asn Ala Phe Tyr Asp Lys Pro Phe Asp 145 150 155 160 Ala Ile Ile Ala Tyr Glu Leu Pro Val Ile Leu Trp Phe Leu Ala His                 165 170 175 Gly Leu Asp Val Val Phe Ile Asp Tyr Pro Arg Asp Pro Ala Thr Gly             180 185 190 Val Gln Tyr Tyr Cys Asp Ser Ile Ala Ala Ala Lys Ser Leu Leu Asp         195 200 205 Ala Val Leu Ala Ser Arg Gln Leu Gly Leu Ser Pro Glu Ala Pro Leu     210 215 220 Gly Leu Trp Gly Phe Ser Gln Gly Gly Gly Ala Thr Gly Trp Ala Ala 225 230 235 240 Gln Leu Gln Asp Tyr Ala Pro Asp Val Arg Pro Lys Ala Ala Val Val                 245 250 255 Gly Ala Pro Pro Val Asp Leu Phe Arg Val Leu Asp Thr Val Asp Gly             260 265 270 Gly Leu Leu Thr Gly Val Ile Ala Tyr Ala Ile Ala Gly Leu Ala Val         275 280 285 Asn Ser Ser Glu Met Phe Glu Glu Ile Met Ser Val Leu Asn Glu Arg     290 295 300 Gly Val Ser Asp Val Leu Lys Asn Ile Thr Ser Cys Ala Gly Gly Ser 305 310 315 320 Leu Leu Ala Ser Gly Tyr Ser Ser Ser Arg Gly Trp Thr His Gln Gly                 325 330 335 Thr Pro Leu Ala Asp Ile Leu Asp Asp Leu Pro Leu Val Val Ala Glu             340 345 350 Phe Gly Lys Gln Lys Leu Gly Arg Val Ala Pro Glu Ile Pro Val Leu         355 360 365 Leu Trp Gly Ser Lys Asn Asp Asp Val Ile Pro Ile Asp Pro Ile Arg     370 375 380 Glu Leu Arg Asp Ser Trp Ala Asp Lys Gly Thr Pro Leu Thr Trp His 385 390 395 400 Glu Ser Gln Ala Pro Arg Val Pro Gly Arg Thr Gly Leu Asn His Phe                 405 410 415 Gly Pro Tyr Phe Arg Asn Leu Glu Lys Tyr Ser Gly Trp Leu Ile Asp             420 425 430 His Leu Val         435 <210> 239 <211> 690 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (667) <223> RXA00875 <400> 239 caatttggcg gcgctgctgg gtgatcgggg gccggttgtt ccgggtgtga ttggtgactg 60 ggtgaggggc taacgcaaca atgtgtctaa gcttaggggc atg act act gag gtt 115                                             Met Thr Thr Glu Val                                               1 5 gaa ctg gtt gtt tta gct gat tcc gag ggc aat cct att ggt act gcg 163 Glu Leu Val Val Leu Ala Asp Ser Glu Gly Asn Pro Ile Gly Thr Ala                  10 15 20 ccg aaa gct acg gtg cac act aag gac acg cct ctg cat ttc gcg ttt 211 Pro Lys Ala Thr Val His Thr Lys Asp Thr Pro Leu His Phe Ala Phe              25 30 35 tcc acc tat att ttg aac ccg cgt ggg gag ctg ttg gtg acg cgt cgt 259 Ser Thr Tyr Ile Leu Asn Pro Arg Gly Glu Leu Leu Val Thr Arg Arg          40 45 50 gca ttg tcg aag aag aca tgg cct ggt gtg tgg acg aac tct atg tgt 307 Ala Leu Ser Lys Lys Thr Trp Pro Gly Val Trp Thr Asn Ser Met Cys      55 60 65 ggg cac cct ggt ccg gat gag aca aac gcg gat gcg att cgt cgc agg 355 Gly His Pro Gly Pro Asp Glu Thr Asn Ala Asp Ala Ile Arg Arg Arg  70 75 80 85 ggt gtc gat gag ttg ggg ctg gag gta gat tct ttc ttg gat att caa 403 Gly Val Asp Glu Leu Gly Leu Glu Val Asp Ser Phe Leu Asp Ile Gln                  90 95 100 gag att ctg cct gat tac cag tac cgt gct gtc gac gcg tcc ggc att 451 Glu Ile Leu Pro Asp Tyr Gln Tyr Arg Ala Val Asp Ala Ser Gly Ile             105 110 115 gtg gag tgg gag ttg tgc ccg gtc cac ctc gtg cgt tta gcg gtg ggg 499 Val Glu Trp Glu Leu Cys Pro Val His Leu Val Arg Leu Ala Val Gly         120 125 130 gaa ttt gtg gag cca ctg gat gat gag gtg gag gag ttc gag tgg gcg 547 Glu Phe Val Glu Pro Leu Asp Asp Glu Val Glu Glu Phe Glu Trp Ala     135 140 145 gaa ccg cag aag ctt ttc gac gct gtt gat gcc aca cca ttt gtg ttt 595 Glu Pro Gln Lys Leu Phe Asp Ala Val Asp Ala Thr Pro Phe Val Phe 150 155 160 165 tct cca tgg cta gtg gat cag ctt agc gcc cct gag ctg cgc caa gcc 643 Ser Pro Trp Leu Val Asp Gln Leu Ser Ala Pro Glu Leu Arg Gln Ala                 170 175 180 atc ctg gaa gcg ttt gac gca gag taactaacta gtctagaagc ctt 690 Ile Leu Glu Ala Phe Asp Ala Glu             185 <210> 240 <211> 189 <212> PRT <213> Corynebacterium glutamicum <400> 240 Met Thr Thr Glu Val Glu Leu Val Val Leu Ala Asp Ser Glu Gly Asn   1 5 10 15 Pro Ile Gly Thr Ala Pro Lys Ala Thr Val His Thr Lys Asp Thr Pro              20 25 30 Leu His Phe Ala Phe Ser Thr Tyr Ile Leu Asn Pro Arg Gly Glu Leu          35 40 45 Leu Val Thr Arg Arg Ala Leu Ser Lys Lys Thr Trp Pro Gly Val Trp      50 55 60 Thr Asn Ser Met Cys Gly His Pro Gly Pro Asp Glu Thr Asn Ala Asp  65 70 75 80 Ala Ile Arg Arg Arg Gly Val Asp Glu Leu Gly Leu Glu Val Asp Ser                  85 90 95 Phe Leu Asp Ile Gln Glu Ile Leu Pro Asp Tyr Gln Tyr Arg Ala Val             100 105 110 Asp Ala Ser Gly Ile Val Glu Trp Glu Leu Cys Pro Val His Leu Val         115 120 125 Arg Leu Ala Val Gly Glu Phe Val Glu Pro Leu Asp Asp Glu Val Glu     130 135 140 Glu Phe Glu Trp Ala Glu Pro Gln Lys Leu Phe Asp Ala Val Asp Ala 145 150 155 160 Thr Pro Phe Val Phe Ser Pro Trp Leu Val Asp Gln Leu Ser Ala Pro                 165 170 175 Glu Leu Arg Gln Ala Ile Leu Glu Ala Phe Asp Ala Glu             180 185 <210> 241 <211> 1308 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1285) <223> RXA01292 <400> 241 tccgcgtccc tcgaagactt aaaaaacggg cgggattttg tgccgtcttt aaaaaagcca 60 gcctggcaac caaagcaatg tggaaagaag tgtttcaaaa atg aca aaa gca gtg 115                                             Met Thr Lys Ala Val                                               1 5 gtc atc ggc ggg gga cta gca gga cta gcc acc acc gca ctg ctc tta 163 Val Ile Gly Gly Gly Leu Ala Gly Leu Ala Thr Thr Ala Leu Leu Leu                  10 15 20 cgc gaa gga tat gaa gtc cac ctc gtc gaa caa aac gag cac ctc ggc 211 Arg Glu Gly Tyr Glu Val His Leu Val Glu Gln Asn Glu His Leu Gly              25 30 35 ggc cgc gcc ggg acc ttc gaa ctc gac ggc ttc cgc tgg gac acc ggc 259 Gly Arg Ala Gly Thr Phe Glu Leu Asp Gly Phe Arg Trp Asp Thr Gly          40 45 50 ccc agc tgg tac ctc atg ccc gac gcc atg tcc cac ttc ttt aag ctc 307 Pro Ser Trp Tyr Leu Met Pro Asp Ala Met Ser His Phe Phe Lys Leu      55 60 65 tgc ggc acc tcc atc gac gac cac ctc gac ctc gtg cca ctt gaa ccc 355 Cys Gly Thr Ser Ile Asp Asp His Leu Asp Leu Val Pro Leu Glu Pro  70 75 80 85 gcc tac cgc gtc atc gac gac cac ggc gaa ttc atc gac gtc acc tcc 403 Ala Tyr Arg Val Ile Asp Asp His Gly Glu Phe Ile Asp Val Thr Ser                  90 95 100 gac atc gat gcg atg gcc gag ctt ttc gaa tcc cgc gaa ccc ggc gcc 451 Asp Ile Asp Ala Met Ala Glu Leu Phe Glu Ser Arg Glu Pro Gly Ala             105 110 115 ggc gcc aaa ctg cgc acc tat atc gac tcc gcc aca cag gtc tac aac 499 Gly Ala Lys Leu Arg Thr Tyr Ile Asp Ser Ala Thr Gln Val Tyr Asn         120 125 130 ctg gcc atc gac ggc ttc ctc tac acc aac ttc acc aac ttc atc cca 547 Leu Ala Ile Asp Gly Phe Leu Tyr Thr Asn Phe Thr Asn Phe Ile Pro     135 140 145 tac tta agc ccc ggc atg ctg cgc ctt tta ccc aaa ctt cta gca agc 595 Tyr Leu Ser Pro Gly Met Leu Arg Leu Leu Pro Lys Leu Leu Ala Ser 150 155 160 165 ctg tcg acc tcg cta aaa gtc aag gtc aac acc caa ttc cgc gat aca 643 Leu Ser Thr Ser Leu Lys Val Lys Val Asn Thr Gln Phe Arg Asp Thr                 170 175 180 aaa ctg cgc caa atc tta agc tac ccc gca gtt ttc ctc tcc tca gac 691 Lys Leu Arg Gln Ile Leu Ser Tyr Pro Ala Val Phe Leu Ser Ser Asp             185 190 195 cct tcg cac acc ccg gcg ctc tat cac ctc atg agc cac acc gac ctc 739 Pro Ser His Thr Pro Ala Leu Tyr His Leu Met Ser His Thr Asp Leu         200 205 210 gtc caa ggc gtc tcc tat ccc cga ggc ggc ttc acc gcc ttc atc aag 787 Val Gln Gly Val Ser Tyr Pro Arg Gly Gly Phe Thr Ala Phe Ile Lys     215 220 225 gca cta att tcg ctt atc gac gac gcc gtc ctc cac ctc ggc acc ccc 835 Ala Leu Ile Ser Leu Ile Asp Asp Ala Val Leu His Leu Gly Thr Pro 230 235 240 245 gtc agc gca atc acc acc caa ggc cga aac gcc aca ggc gtc caa gtc 883 Val Ser Ala Ile Thr Thr Gln Gly Arg Asn Ala Thr Gly Val Gln Val                 250 255 260 ggc tca gag ttc atc gaa gcc gat atc gtg atc agc tgc gct gat cag 931 Gly Ser Glu Phe Ile Glu Ala Asp Ile Val Ile Ser Cys Ala Asp Gln             265 270 275 cac cac acc gaa acc caa ctc cta cct gct tcg ttg tgc gcg aag ccg 979 His His Thr Glu Thr Gln Leu Leu Pro Ala Ser Leu Cys Ala Lys Pro         280 285 290 gag acg agc tgg aag aac aaa caa ccc ggc ctc agt act gtg ctg gtt 1027 Glu Thr Ser Trp Lys Asn Lys Gln Pro Gly Leu Ser Thr Val Leu Val     295 300 305 ttg gca ggc gtg aag ggg gag cac acc ctg ctt ttt cct ccg act ggg 1075 Leu Ala Gly Val Lys Gly Glu His Thr Leu Leu Phe Pro Pro Thr Gly 310 315 320 325 acg aag att tcc gca aag ttt tcg acg gct cca ccc cag aat tcc cgg 1123 Thr Lys Ile Ser Ala Lys Phe Ser Thr Ala Pro Pro Gln Asn Ser Arg                 330 335 340 ctt cag aat cca tct aga tct cca aga cct ccg caa cag att ccg atg 1171 Leu Gln Asn Pro Ser Arg Ser Pro Arg Pro Pro Gln Gln Ile Pro Met             345 350 355 ccg cac ccg aag gcc acg aga acc tct tca tcc tgg tcc cag tac ccg 1219 Pro His Pro Lys Ala Thr Arg Thr Ser Ser Ser Trp Ser Gln Tyr Pro         360 365 370 ccg atg tct cca ttg gtc acg ggt ccg ctt acg gag aag aat ctg aca 1267 Pro Met Ser Pro Leu Val Thr Gly Pro Leu Thr Glu Lys Asn Leu Thr     375 380 385 tgg tgg gcc gga tcg caa tagcagcagt ggctcaaatt ggg 1308 Trp Trp Ala Gly Ser Gln 390 395 <210> 242 <211> 395 <212> PRT <213> Corynebacterium glutamicum <400> 242 Met Thr Lys Ala Val Val Ile Gly Gly Gly Leu Ala Gly Leu Ala Thr   1 5 10 15 Thr Ala Leu Leu Leu Arg Glu Gly Tyr Glu Val His Leu Val Glu Gln              20 25 30 Asn Glu His Leu Gly Gly Arg Ala Gly Thr Phe Glu Leu Asp Gly Phe          35 40 45 Arg Trp Asp Thr Gly Pro Ser Trp Tyr Leu Met Pro Asp Ala Met Ser      50 55 60 His Phe Phe Lys Leu Cys Gly Thr Ser Ile Asp Asp His Leu Asp Leu  65 70 75 80 Val Pro Leu Glu Pro Ala Tyr Arg Val Ile Asp Asp His Gly Glu Phe                  85 90 95 Ile Asp Val Thr Ser Asp Ile Asp Ala Met Ala Glu Leu Phe Glu Ser             100 105 110 Arg Glu Pro Gly Ala Gly Ala Lys Leu Arg Thr Tyr Ile Asp Ser Ala         115 120 125 Thr Gln Val Tyr Asn Leu Ala Ile Asp Gly Phe Leu Tyr Thr Asn Phe     130 135 140 Thr Asn Phe Ile Pro Tyr Leu Ser Pro Gly Met Leu Arg Leu Leu Pro 145 150 155 160 Lys Leu Leu Ala Ser Leu Ser Thr Ser Leu Lys Val Lys Val Asn Thr                 165 170 175 Gln Phe Arg Asp Thr Lys Leu Arg Gln Ile Leu Ser Tyr Pro Ala Val             180 185 190 Phe Leu Ser Ser Asp Pro Ser His Thr Pro Ala Leu Tyr His Leu Met         195 200 205 Ser His Thr Asp Leu Val Gln Gly Val Ser Tyr Pro Arg Gly Gly Phe     210 215 220 Thr Ala Phe Ile Lys Ala Leu Ile Ser Leu Ile Asp Asp Ala Val Leu 225 230 235 240 His Leu Gly Thr Pro Val Ser Ala Ile Thr Thr Gln Gly Arg Asn Ala                 245 250 255 Thr Gly Val Gln Val Gly Ser Glu Phe Ile Glu Ala Asp Ile Val Ile             260 265 270 Ser Cys Ala Asp Gln His His Thr Glu Thr Gln Leu Leu Pro Ala Ser         275 280 285 Leu Cys Ala Lys Pro Glu Thr Ser Trp Lys Asn Lys Gln Pro Gly Leu     290 295 300 Ser Thr Val Leu Val Leu Ala Gly Val Lys Gly Glu His Thr Leu Leu 305 310 315 320 Phe Pro Pro Thr Gly Thr Lys Ile Ser Ala Lys Phe Ser Thr Ala Pro                 325 330 335 Pro Gln Asn Ser Arg Leu Gln Asn Pro Ser Arg Ser Pro Arg Pro Pro             340 345 350 Gln Gln Ile Pro Met Pro His Pro Lys Ala Thr Arg Thr Ser Ser Ser         355 360 365 Trp Ser Gln Tyr Pro Pro Met Ser Pro Leu Val Thr Gly Pro Leu Thr     370 375 380 Glu Lys Asn Leu Thr Trp Trp Ala Gly Ser Gln 385 390 395 <210> 243 <211> 450 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (427) <223> RXA01293 <400> 243 cgatgccgca cccgaaggcc acgagaacct cttcatcctg gtcccagtac ccgccgatgt 60 ctccattggt cacgggtccg cttacggaga agaatctgac atg gtg ggc cgg atc 115                                             Met val gly arg yle                                               1 5 gca ata gca gca gtg gct caa att ggg cga tgg gct ggc att gat ggt 163 Ala Ile Ala Ala Val Ala Gln Ile Gly Arg Trp Ala Gly Ile Asp Gly                  10 15 20 ttg gaa agc cgc att gtt gtg cag cgc acc atc ggc cct gcc gac ttc 211 Leu Glu Ser Arg Ile Val Val Gln Arg Thr Ile Gly Pro Ala Asp Phe              25 30 35 gca gac cga tac aac tcc tgg agc ggc ggg tcc att ggc ccc tca cac 259 Ala Asp Arg Tyr Asn Ser Trp Ser Gly Gly Ser Ile Gly Pro Ser His          40 45 50 acc ctg gca caa tcg gcg ttc ttt agg ggt tct aac aaa tcc cgc aaa 307 Thr Leu Ala Gln Ser Ala Phe Phe Arg Gly Ser Asn Lys Ser Arg Lys      55 60 65 gta gat ggc ctg tat gac gca ggt gac acc aca gtt cca ggg gtg ggc 355 Val Asp Gly Leu Tyr Asp Ala Gly Asp Thr Thr Val Pro Gly Val Gly  70 75 80 85 gta tct atg tgt ttg atc tct gca gaa aac gtg ctc aag cgt ctc cgc 403 Val Ser Met Cys Leu Ile Ser Ala Glu Asn Val Leu Lys Arg Leu Arg                  90 95 100 ggg gac aac agt gtg gat cgg act taacgggact tttttctttt gct 450 Gly Asp Asn Ser Val Asp Arg Thr             105 <210> 244 <211> 109 <212> PRT <213> Corynebacterium glutamicum <400> 244 Met Val Gly Arg Ile Ala Ile Ala Ala Val Ala Gln Ile Gly Arg Trp   1 5 10 15 Ala Gly Ile Asp Gly Leu Glu Ser Arg Ile Val Val Gln Arg Thr Ile              20 25 30 Gly Pro Ala Asp Phe Ala Asp Arg Tyr Asn Ser Trp Ser Gly Gly Ser          35 40 45 Ile Gly Pro Ser His Thr Leu Ala Gln Ser Ala Phe Phe Arg Gly Ser      50 55 60 Asn Lys Ser Arg Lys Val Asp Gly Leu Tyr Asp Ala Gly Asp Thr Thr  65 70 75 80 Val Pro Gly Val Gly Val Ser Met Cys Leu Ile Ser Ala Glu Asn Val                  85 90 95 Leu Lys Arg Leu Arg Gly Asp Asn Ser Val Asp Arg Thr             100 105 <210> 245 <211> 1386 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (101) .. (1363) <223> RXA02310 <400> 245 gaaatggaca aaaagctttt tgtttaaccg tagtcgacgg aaggcacttg aagcaccttg 60 ggttagtctt cttgctctcc ggactgagac aatggggttt gtg tct aca act ttt 115                                             Val Ser Thr Thr Phe                                               1 5 gat gtg ttg atc atc ggc gcg ggc ccc tca ggt gcc agc gcc gcc gtc 163 Asp Val Leu Ile Ile Gly Ala Gly Pro Ser Gly Ala Ser Ala Ala Val                  10 15 20 cat gcg gcc agg act ggg ctt caa aca ttg ctt atc gac gcc tcc tcc 211 His Ala Ala Arg Thr Gly Leu Gln Thr Leu Leu Ile Asp Ala Ser Ser              25 30 35 ttc ccg cgg gat aaa acg tgt ggc gat ggc ctt act ccc cgt gcg att 259 Phe Pro Arg Asp Lys Thr Cys Gly Asp Gly Leu Thr Pro Arg Ala Ile          40 45 50 cac cag cta gaa ctt cta ggt gtt gct gat cag gtt acc ggg gat tat 307 His Gln Leu Glu Leu Leu Gly Val Ala Asp Gln Val Thr Gly Asp Tyr      55 60 65 ttc aac aag ggc ttg aaa ctg cat ggt ttt ggt ggc tct gtt gag gcg 355 Phe Asn Lys Gly Leu Lys Leu His Gly Phe Gly Gly Ser Val Glu Ala  70 75 80 85 ccg tgg ccg gag aca tat ttc acg aat aag ggt tcc gcg atg tcg cgg 403 Pro Trp Pro Glu Thr Tyr Phe Thr Asn Lys Gly Ser Ala Met Ser Arg                  90 95 100 atg gag ttc gat gat ttg tta ttc cgc ttg gca aaa tct cat gag gaa 451 Met Glu Phe Asp Asp Leu Leu Phe Arg Leu Ala Lys Ser His Glu Glu             105 110 115 gta acc acg tgg gag aac gcg agc gcc caa gac ccc att ttg agg ggg 499 Val Thr Thr Trp Glu Asn Ala Ser Ala Gln Asp Pro Ile Leu Arg Gly         120 125 130 aat ttc ttg gaa ggc gtt gtg att aat cac gca ggg caa gag aaa acc 547 Asn Phe Leu Glu Gly Val Val Ile Asn His Ala Gly Gln Glu Lys Thr     135 140 145 gtc aag gcg aag cat gtg att att gcc gat ggt gtc cgc tcc cct ttc 595 Val Lys Ala Lys His Val Ile Ile Ala Asp Gly Val Arg Ser Pro Phe 150 155 160 165 ggt aag aaa ctg ggt agg cag tgg caa cgc gat gag gtg tat ggc att 643 Gly Lys Lys Leu Gly Arg Gln Trp Gln Arg Asp Glu Val Tyr Gly Ile                 170 175 180 gcg gct cgt gct tat tgt gaa act ccg ctg tct gat gaa ccg tgg att 691 Ala Ala Arg Ala Tyr Cys Glu Thr Pro Leu Ser Asp Glu Pro Trp Ile             185 190 195 cac tcc cat gtg gaa ctg cgc gat gaa gat ggt gtg gtg cag cca gga 739 His Ser His Val Glu Leu Arg Asp Glu Asp Gly Val Val Gln Pro Gly         200 205 210 tat ggg tgg att ttc ccg ctg ggc aac ggc acg gtg aat ttg ggt tgt 787 Tyr Gly Trp Ile Phe Pro Leu Gly Asn Gly Thr Val Asn Leu Gly Cys     215 220 225 ggc gcg ctc tcg acg gat acg aga cca gcg aag atc aat acg aag aaa 835 Gly Ala Leu Ser Thr Asp Thr Arg Pro Ala Lys Ile Asn Thr Lys Lys 230 235 240 245 ttg ttg agc ttc tat gcg ggt cag cgt cgt aaa gca tgg caa ctc ggg 883 Leu Leu Ser Phe Tyr Ala Gly Gln Arg Arg Lys Ala Trp Gln Leu Gly                 250 255 260 ccc gag cac gac gtc gcc tct gcc ctg ctg cct atg ggc ggc gcg gtg 931 Pro Glu His Asp Val Ala Ser Ala Leu Leu Pro Met Gly Gly Ala Val             265 270 275 tcg aat gtg gct ggc gcg aac tgg atg ctg atc ggc gat tcc gcc gcg 979 Ser Asn Val Ala Gly Ala Asn Trp Met Leu Ile Gly Asp Ser Ala Ala         280 285 290 tgt gtg aac ccg ctg aac ggc gaa ggc atc gac tat ggc ctg gaa acc 1027 Cys Val Asn Pro Leu Asn Gly Glu Gly Ile Asp Tyr Gly Leu Glu Thr     295 300 305 gcg gcg atg gcc gtc gac acg ctt gtg gaa aac ccc aag cgc gat ttg 1075 Ala Ala Met Ala Val Asp Thr Leu Val Glu Asn Pro Lys Arg Asp Leu 310 315 320 325 acc ttg gta tgg cca cat agg ttg cgc gac gcg tac ggc gag acc ttc 1123 Thr Leu Val Trp Pro His Arg Leu Arg Asp Ala Tyr Gly Glu Thr Phe                 330 335 340 atg ttg gcg cgc acg gct gct cga ctg ctg acg tac ccg cag ttt ttg 1171 Met Leu Ala Arg Thr Ala Ala Arg Leu Leu Thr Tyr Pro Gln Phe Leu             345 350 355 ccg atg gct ggg ccg ctc gca ttc cgc ggg ccg ctg caa aag gcc atc 1219 Pro Met Ala Gly Pro Leu Ala Phe Arg Gly Pro Leu Gln Lys Ala Ile         360 365 370 atg ccg gcg gct gcg cgt ttg atg ggc aac ctg atc aca gag gag gat 1267 Met Pro Ala Ala Ala Arg Leu Met Gly Asn Leu Ile Thr Glu Glu Asp     375 380 385 aaa gac ctg ctc gcc agg ggt tgg cag gcc gcc gga tcc gcg att agt 1315 Lys Asp Leu Leu Ala Arg Gly Trp Gln Ala Ala Gly Ser Ala Ile Ser 390 395 400 405 tgg gcg cgg aag ggc tcc cct ctg tgg gac tcg act agt tct ctg gtt 1363 Trp Ala Arg Lys Gly Ser Pro Leu Trp Asp Ser Thr Ser Ser Leu Val                 410 415 420 taatcgccga gtgcagcgcg acg 1386 <210> 246 <211> 421 <212> PRT <213> Corynebacterium glutamicum <400> 246 Val Ser Thr Thr Phe Asp Val Leu Ile Ile Gly Ala Gly Pro Ser Gly   1 5 10 15 Ala Ser Ala Ala Val His Ala Ala Arg Thr Gly Leu Gln Thr Leu Leu              20 25 30 Ile Asp Ala Ser Ser Phe Pro Arg Asp Lys Thr Cys Gly Asp Gly Leu          35 40 45 Thr Pro Arg Ala Ile His Gln Leu Glu Leu Leu Gly Val Ala Asp Gln      50 55 60 Val Thr Gly Asp Tyr Phe Asn Lys Gly Leu Lys Leu His Gly Phe Gly  65 70 75 80 Gly Ser Val Glu Ala Pro Trp Pro Glu Thr Tyr Phe Thr Asn Lys Gly                  85 90 95 Ser Ala Met Ser Arg Met Glu Phe Asp Asp Leu Leu Phe Arg Leu Ala             100 105 110 Lys Ser His Glu Glu Val Thr Thr Trp Glu Asn Ala Ser Ala Gln Asp         115 120 125 Pro Ile Leu Arg Gly Asn Phe Leu Glu Gly Val Val Ile Asn His Ala     130 135 140 Gly Gln Glu Lys Thr Val Lys Ala Lys His Val Ile Ile Ala Asp Gly 145 150 155 160 Val Arg Ser Pro Phe Gly Lys Lys Leu Gly Arg Gln Trp Gln Arg Asp                 165 170 175 Glu Val Tyr Gly Ile Ala Ala Arg Ala Tyr Cys Glu Thr Pro Leu Ser             180 185 190 Asp Glu Pro Trp Ile His Ser His Val Glu Leu Arg Asp Glu Asp Gly         195 200 205 Val Val Gln Pro Gly Tyr Gly Trp Ile Phe Pro Leu Gly Asn Gly Thr     210 215 220 Val Asn Leu Gly Cys Gly Ala Leu Ser Thr Asp Thr Arg Pro Ala Lys 225 230 235 240 Ile Asn Thr Lys Lys Leu Leu Ser Phe Tyr Ala Gly Gln Arg Arg Lys                 245 250 255 Ala Trp Gln Leu Gly Pro Glu His Asp Val Ala Ser Ala Leu Leu Pro             260 265 270 Met Gly Gly Ala Val Ser Asn Val Ala Gly Ala Asn Trp Met Leu Ile         275 280 285 Gly Asp Ser Ala Ala Cys Val Asn Pro Leu Asn Gly Glu Gly Ile Asp     290 295 300 Tyr Gly Leu Glu Thr Ala Ala Met Ala Val Asp Thr Leu Val Glu Asn 305 310 315 320 Pro Lys Arg Asp Leu Thr Leu Val Trp Pro His Arg Leu Arg Asp Ala                 325 330 335 Tyr Gly Glu Thr Phe Met Leu Ala Arg Thr Ala Ala Arg Leu Leu Thr             340 345 350 Tyr Pro Gln Phe Leu Pro Met Ala Gly Pro Leu Ala Phe Arg Gly Pro         355 360 365 Leu Gln Lys Ala Ile Met Pro Ala Ala Ala Arg Leu Met Gly Asn Leu     370 375 380 Ile Thr Glu Glu Asp Lys Asp Leu Leu Ala Arg Gly Trp Gln Ala Ala 385 390 395 400 Gly Ser Ala Ile Ser Trp Ala Arg Lys Gly Ser Pro Leu Trp Asp Ser                 405 410 415 Thr Ser Ser Leu Val             420 <210> 247 <211> 1170 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (1147) <223> RXA02718 <400> 247 tccaccaaaa ttcagcccgc atccccctat tcgattgaag gacgtctcct tgagcagttt 60 cgatgcccat gaccttgacc tcgacaaatt tccggaggtc gtg cga gat cgt ttg 115                                             Val Arg Asp Arg Leu                                               1 5 acg cag ttc ctc gat gct caa gag cta aca att gct gat atc ggc gct 163 Thr Gln Phe Leu Asp Ala Gln Glu Leu Thr Ile Ala Asp Ile Gly Ala                  10 15 20 cct gtc aca gat gct gtg gcc cat ctt cgc agt ttc gtg ctc aat gga 211 Pro Val Thr Asp Ala Val Ala His Leu Arg Ser Phe Val Leu Asn Gly              25 30 35 gga aag cga atc cgt cct ctt tat gcg tgg gct ggt ttc ctg gcg gcg 259 Gly Lys Arg Ile Arg Pro Leu Tyr Ala Trp Ala Gly Phe Leu Ala Ala          40 45 50 caa ggc cat aag aat tct tct gaa aaa ctt gag tcc gtc ctt gac gcc 307 Gln Gly His Lys Asn Ser Ser Glu Lys Leu Glu Ser Val Leu Asp Ala      55 60 65 gca gcg agt ctc gaa ttc atc cag gct tgt gcc ttg att cat gac gat 355 Ala Ala Ser Leu Glu Phe Ile Gln Ala Cys Ala Leu Ile His Asp Asp  70 75 80 85 att atc gat tct tct gat acc cgg cgc gga gcc ccc aca gtt cac cgg 403 Ile Ile Asp Ser Ser Asp Thr Arg Arg Gly Ala Pro Thr Val His Arg                  90 95 100 gct gtg gaa gct gat cac cgc gcc aat aat ttc gaa ggc gat ccc gag 451 Ala Val Glu Ala Asp His Arg Ala Asn Asn Phe Glu Gly Asp Pro Glu             105 110 115 cac ttt ggc gtt tca gtc tcg att ttg gct ggc gat atg gca ttg gtg 499 His Phe Gly Val Ser Val Ser Ile Leu Ala Gly Asp Met Ala Leu Val         120 125 130 tgg gca gaa gac atg ctg cag gat tcc ggt ttg agt gca gag gca ttg 547 Trp Ala Glu Asp Met Leu Gln Asp Ser Gly Leu Ser Ala Glu Ala Leu     135 140 145 gcc cgc acg agg gat gct tgg cgt ggc atg cgt act gag gtt att ggc 595 Ala Arg Thr Arg Asp Ala Trp Arg Gly Met Arg Thr Glu Val Ile Gly 150 155 160 165 ggc cag ctg ctt gat att tat cta gag tcg cac gcc aac gag tcg gtg 643 Gly Gln Leu Leu Asp Ile Tyr Leu Glu Ser His Ala Asn Glu Ser Val                 170 175 180 gag ctt gcg gat tct gtc aac cgc ttc aaa acg gcc gct tac acg att 691 Glu Leu Ala Asp Ser Val Asn Arg Phe Lys Thr Ala Ala Tyr Thr Ile             185 190 195 gcg cgc cca ttg cac ctg ggc gcc tcc att gct ggc ggt tcg ccg cag 739 Ala Arg Pro Leu His Leu Gly Ala Ser Ile Ala Gly Gly Ser Pro Gln         200 205 210 ctt atc gac gcg ctc ctc cac tac ggc cac gac atc ggc att gca ttc 787 Leu Ile Asp Ala Leu Leu His Tyr Gly His Asp Ile Gly Ile Ala Phe     215 220 225 cag ttg agg gat gat ctg ctt ggt gtg ttt ggg gat ccc gct atc acc 835 Gln Leu Arg Asp Asp Leu Leu Gly Val Phe Gly Asp Pro Ala Ile Thr 230 235 240 245 ggc aaa cca gct gga gac gat atc cgt gaa ggc aag cgc act gtt ctt 883 Gly Lys Pro Ala Gly Asp Asp Ile Arg Glu Gly Lys Arg Thr Val Leu                 250 255 260 ctt gcg ctc gct cta caa cgc gct gat aag caa tct cct gaa gct gca 931 Leu Ala Leu Ala Leu Gln Arg Ala Asp Lys Gln Ser Pro Glu Ala Ala             265 270 275 acg gcc att cgc gca ggt gtt gga aag gtg act tca cca gaa gat att 979 Thr Ala Ile Arg Ala Gly Val Gly Lys Val Thr Ser Pro Glu Asp Ile         280 285 290 gct gtc att aca gag cat att cga gct act ggt gct gaa gaa gaa gtt 1027 Ala Val Ile Thr Glu His Ile Arg Ala Thr Gly Ala Glu Glu Glu Val     295 300 305 gag cag cga att tcc cag ctg act gaa tcc ggt ttg gct cac ctc gat 1075 Glu Gln Arg Ile Ser Gln Leu Thr Glu Ser Gly Leu Ala His Leu Asp 310 315 320 325 gat gta gac atc ccc gat gag gtg cgc gca cag ttg cgg gca ctg gct 1123 Asp Val Asp Ile Pro Asp Glu Val Arg Ala Gln Leu Arg Ala Leu Ala                 330 335 340 atc cgc tca acc gaa cgt cgg atg tagtagacgc gtatgacact ttt 1170 Ile Arg Ser Thr Glu Arg Arg Met             345 <210> 248 <211> 349 <212> PRT <213> Corynebacterium glutamicum <400> 248 Val Arg Asp Arg Leu Thr Gln Phe Leu Asp Ala Gln Glu Leu Thr Ile   1 5 10 15 Ala Asp Ile Gly Ala Pro Val Thr Asp Ala Val Ala His Leu Arg Ser              20 25 30 Phe Val Leu Asn Gly Gly Lys Arg Ile Arg Pro Leu Tyr Ala Trp Ala          35 40 45 Gly Phe Leu Ala Ala Gln Gly His Lys Asn Ser Ser Glu Lys Leu Glu      50 55 60 Ser Val Leu Asp Ala Ala Ala Ser Leu Glu Phe Ile Gln Ala Cys Ala  65 70 75 80 Leu Ile His Asp Asp Ile Ile Asp Ser Ser Asp Thr Arg Arg Gly Ala                  85 90 95 Pro Thr Val His Arg Ala Val Glu Ala Asp His Arg Ala Asn Asn Phe             100 105 110 Glu Gly Asp Pro Glu His Phe Gly Val Ser Val Ser Ile Leu Ala Gly         115 120 125 Asp Met Ala Leu Val Trp Ala Glu Asp Met Leu Gln Asp Ser Gly Leu     130 135 140 Ser Ala Glu Ala Leu Ala Arg Thr Arg Asp Ala Trp Arg Gly Met Arg 145 150 155 160 Thr Glu Val Ile Gly Gly Gln Leu Leu Asp Ile Tyr Leu Glu Ser His                 165 170 175 Ala Asn Glu Ser Val Glu Leu Ala Asp Ser Val Asn Arg Phe Lys Thr             180 185 190 Ala Ala Tyr Thr Ile Ala Arg Pro Leu His Leu Gly Ala Ser Ile Ala         195 200 205 Gly Gly Ser Pro Gln Leu Ile Asp Ala Leu Leu His Tyr Gly His Asp     210 215 220 Ile Gly Ile Ala Phe Gln Leu Arg Asp Asp Leu Leu Gly Val Phe Gly 225 230 235 240 Asp Pro Ala Ile Thr Gly Lys Pro Ala Gly Asp Asp Ile Arg Glu Gly                 245 250 255 Lys Arg Thr Val Leu Leu Ala Leu Ala Leu Gln Arg Ala Asp Lys Gln             260 265 270 Ser Pro Glu Ala Ala Thr Ala Ile Arg Ala Gly Val Gly Lys Val Thr         275 280 285 Ser Pro Glu Asp Ile Ala Val Ile Thr Glu His Ile Arg Ala Thr Gly     290 295 300 Ala Glu Glu Glu Val Glu Gln Arg Ile Ser Gln Leu Thr Glu Ser Gly 305 310 315 320 Leu Ala His Leu Asp Asp Val Asp Ile Pro Asp Glu Val Arg Ala Gln                 325 330 335 Leu Arg Ala Leu Ala Ile Arg Ser Thr Glu Arg Arg Met             340 345 <210> 249 <211> 852 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (829) <223> RXA01067 <400> 249 ggctttaagg ccgaggtgcc tggctgaact gcagcccctc cagaccctga gatcaggcta 60 aatggcaaac acaaatagtt tgcatggcag aatagcttag gtg agt gaa ttc caa 115                                             Val Ser Glu Phe Gln                                               1 5 gta ccc gaa atc cct gcc caa ttc cta ccc aag cat att gcg ctt gtc 163 Val Pro Glu Ile Pro Ala Gln Phe Leu Pro Lys His Ile Ala Leu Val                  10 15 20 atg gat gga aat gga cgc tgg gct acc gag cgt ggc atg aag cgc acc 211 Met Asp Gly Asn Gly Arg Trp Ala Thr Glu Arg Gly Met Lys Arg Thr              25 30 35 gaa ggc cat aag cgt ggc gag gca gtc ctg ctt gat gtt gtt gat gca 259 Glu Gly His Lys Arg Gly Glu Ala Val Leu Leu Asp Val Val Asp Ala          40 45 50 tgc att gaa ctt ggt gtt ccg tac ctt tct gct tat gcc ttc tct act 307 Cys Ile Glu Leu Gly Val Pro Tyr Leu Ser Ala Tyr Ala Phe Ser Thr      55 60 65 gaa aac tgg cgt cgt tcc acc gat gag gtc cgt ttc ctc atg gga ttc 355 Glu Asn Trp Arg Arg Ser Thr Asp Glu Val Arg Phe Leu Met Gly Phe  70 75 80 85 aac cga gat gtg ctg cga cga caa cgc gat gac cta cat gaa aag ggc 403 Asn Arg Asp Val Leu Arg Arg Gln Arg Asp Asp Leu His Glu Lys Gly                  90 95 100 gtt cgt gtg cgt tgg gtt ggc cgt cgt ccc cgc ctg tgg cgt tcg gtt 451 Val Arg Val Arg Trp Val Gly Arg Arg Pro Arg Leu Trp Arg Ser Val             105 110 115 atc cgt gag ctg gaa act gcg gaa gag cta acc aaa gac aac acc acc 499 Ile Arg Glu Leu Glu Thr Ala Glu Glu Leu Thr Lys Asp Asn Thr Thr         120 125 130 atg acc ttg gcc atg tgt gtg aac tat ggt gga cgc gcc gaa atc atc 547 Met Thr Leu Ala Met Cys Val Asn Tyr Gly Gly Arg Ala Glu Ile Ile     135 140 145 gac gca gcc cgc gac atc gcc cgc ctt gca gct gaa ggc aaa ctg cgc 595 Asp Ala Ala Arg Asp Ile Ala Arg Leu Ala Ala Glu Gly Lys Leu Arg 150 155 160 165 ccg gaa caa atc act gag aag acc ttc ccg aac ttc ctc gac gaa cct 643 Pro Glu Gln Ile Thr Glu Lys Thr Phe Pro Asn Phe Leu Asp Glu Pro                 170 175 180 gac atg cca gac gtc gac ctg ttc ctg cgc cca tcc ggt gag aag cgc 691 Asp Met Pro Asp Val Asp Leu Phe Leu Arg Pro Ser Gly Glu Lys Arg             185 190 195 acg tca aac ttc ctg ctg tgg cag tct gcc tac gcg gaa atg gtc tac 739 Thr Ser Asn Phe Leu Leu Trp Gln Ser Ala Tyr Ala Glu Met Val Tyr         200 205 210 caa gac aag ctg ttc cct gat ttc acg cag caa gat ctg tac gac gcg 787 Gln Asp Lys Leu Phe Pro Asp Phe Thr Gln Gln Asp Leu Tyr Asp Ala     215 220 225 gtc ctg gaa tac gcc aag cgg gat cgc aga ttc gga agc gca 829 Val Leu Glu Tyr Ala Lys Arg Asp Arg Arg Phe Gly Ser Ala 230 235 240 taatgcccac caaccagccg acg 852 <210> 250 <211> 243 <212> PRT <213> Corynebacterium glutamicum <400> 250 Val Ser Glu Phe Gln Val Pro Glu Ile Pro Ala Gln Phe Leu Pro Lys   1 5 10 15 His Ile Ala Leu Val Met Asp Gly Asn Gly Arg Trp Ala Thr Glu Arg              20 25 30 Gly Met Lys Arg Thr Glu Gly His Lys Arg Gly Glu Ala Val Leu Leu          35 40 45 Asp Val Val Asp Ala Cys Ile Glu Leu Gly Val Pro Tyr Leu Ser Ala      50 55 60 Tyr Ala Phe Ser Thr Glu Asn Trp Arg Arg Ser Thr Asp Glu Val Arg  65 70 75 80 Phe Leu Met Gly Phe Asn Arg Asp Val Leu Arg Arg Gln Arg Asp Asp                  85 90 95 Leu His Glu Lys Gly Val Arg Val Arg Trp Val Gly Arg Arg Pro Arg             100 105 110 Leu Trp Arg Ser Val Ile Arg Glu Leu Glu Thr Ala Glu Glu Leu Thr         115 120 125 Lys Asp Asn Thr Thr Met Met Leu Ala Met Cys Val Asn Tyr Gly Gly     130 135 140 Arg Ala Glu Ile Ile Asp Ala Ala Arg Asp Ile Ala Arg Leu Ala Ala 145 150 155 160 Glu Gly Lys Leu Arg Pro Glu Gln Ile Thr Glu Lys Thr Phe Pro Asn                 165 170 175 Phe Leu Asp Glu Pro Asp Met Pro Asp Val Asp Leu Phe Leu Arg Pro             180 185 190 Ser Gly Glu Lys Arg Thr Ser Asn Phe Leu Leu Trp Gln Ser Ala Tyr         195 200 205 Ala Glu Met Val Tyr Gln Asp Lys Leu Phe Pro Asp Phe Thr Gln Gln     210 215 220 Asp Leu Tyr Asp Ala Val Leu Glu Tyr Ala Lys Arg Asp Arg Arg Phe 225 230 235 240 Gly ser ala <210> 251 <211> 564 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (541) <223> RXA01269 <400> 251 gattatctct gcgccgattc agctggcaat agcagcagtt gtattgagag ctcatggtcg 60 tccgattcta tttcgtcaac cacgacctgg gaaagacggt gtg gta ttt gag atg 115                                             Val Val Phe Glu Met                                               1 5 att aag ttt cga acc atg ctt gaa cca gat gaa aaa cat gta act gat 163 Ile Lys Phe Arg Thr Met Leu Glu Pro Asp Glu Lys His Val Thr Asp                  10 15 20 gaa cag cgt cta act aaa gtt gga aag ctt ctg cgg gaa acg agt tta 211 Glu Gln Arg Leu Thr Lys Val Gly Lys Leu Leu Arg Glu Thr Ser Leu              25 30 35 gat gag tta cct aca ctc tgg aat gta ttt aaa ggt gat atg agc ctt 259 Asp Glu Leu Pro Thr Leu Trp Asn Val Phe Lys Gly Asp Met Ser Leu          40 45 50 gta ggg cct cga cct ttg ctt gtt agc tat ctg gaa cat tac tct tct 307 Val Gly Pro Arg Pro Leu Leu Val Ser Tyr Leu Glu His Tyr Ser Ser      55 60 65 gaa caa gct cga cgc cat gaa gtt cgt cct ggg att act ggt ttg gct 355 Glu Gln Ala Arg Arg His Glu Val Arg Pro Gly Ile Thr Gly Leu Ala  70 75 80 85 cag gtg aat ggc cgt aat caa act act tgg gat gaa cga ctt aag ttg 403 Gln Val Asn Gly Arg Asn Gln Thr Thr Trp Asp Glu Arg Leu Lys Leu                  90 95 100 gat gtc gaa tat gtg gat cgc tgt agt ttg aaa cta gat ttc aaa ata 451 Asp Val Glu Tyr Val Asp Arg Cys Ser Leu Lys Leu Asp Phe Lys Ile             105 110 115 tta atc gcc act gta aaa aca gtt ctt tct aaa aag ggc att agt aat 499 Leu Ile Ala Thr Val Lys Thr Val Leu Ser Lys Lys Gly Ile Ser Asn         120 125 130 gaa ggt cat gtc acg atg cca tcc ttc att gaa gaa aga aaa 541 Glu Gly His Val Thr Met Pro Ser Phe Ile Glu Glu Arg Lys     135 140 145 tagcaggtaa aaattttact ttc 564 <210> 252 <211> 147 <212> PRT <213> Corynebacterium glutamicum <400> 252 Val Val Phe Glu Met Ile Lys Phe Arg Thr Met Leu Glu Pro Asp Glu   1 5 10 15 Lys His Val Thr Asp Glu Gln Arg Leu Thr Lys Val Gly Lys Leu Leu              20 25 30 Arg Glu Thr Ser Leu Asp Glu Leu Pro Thr Leu Trp Asn Val Phe Lys          35 40 45 Gly Asp Met Ser Leu Val Gly Pro Arg Pro Leu Leu Val Ser Tyr Leu      50 55 60 Glu His Tyr Ser Ser Glu Gln Ala Arg Arg His Glu Val Arg Pro Gly  65 70 75 80 Ile Thr Gly Leu Ala Gln Val Asn Gly Arg Asn Gln Thr Thr Trp Asp                  85 90 95 Glu Arg Leu Lys Leu Asp Val Glu Tyr Val Asp Arg Cys Ser Leu Lys             100 105 110 Leu Asp Phe Lys Ile Leu Ile Ala Thr Val Lys Thr Val Leu Ser Lys         115 120 125 Lys Gly Ile Ser Asn Glu Gly His Val Thr Met Pro Ser Phe Ile Glu     130 135 140 Glu arg lys 145 <210> 253 <211> 554 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (531) <223> RXA01205 <400> 253 gta tcg gcc tat ccg ccg gcc atc atc gca gcg gct ctc gta gga att 48 Val Ser Ala Tyr Pro Pro Ala Ile Ile Ala Ala Ala Leu Val Gly Ile   1 5 10 15 tgc gcg gga gtt ttg ccc cat aat ttt gaa ccc tcg cga ata ttt atg 96 Cys Ala Gly Val Leu Pro His Asn Phe Glu Pro Ser Arg Ile Phe Met              20 25 30 ggc gat tcc ggc tcc atg ctc atc ggc ctg ctg ttg gct gca gca tcg 144 Gly Asp Ser Gly Ser Met Leu Ile Gly Leu Leu Leu Ala Ala Ala Ser          35 40 45 acc tca gcg tca gga aaa atc aac atg agc ctg tat ggc gca gct gat 192 Thr Ser Ala Ser Gly Lys Ile Asn Met Ser Leu Tyr Gly Ala Ala Asp      50 55 60 ttt atc gca ttg atc tca ccc atc atc gtt gtt ctc gcc gcc gtg gcc 240 Phe Ile Ala Leu Ile Ser Pro Ile Ile Val Val Leu Ala Ala Val Ala  65 70 75 80 atc cca ctg ctc gac ctc gtg atg gca gtg gtt agg cgc gtg ggc agg 288 Ile Pro Leu Leu Asp Leu Val Met Ala Val Val Arg Arg Val Gly Arg                  85 90 95 gga gca tca ccc ttt tcc ccg gac aaa atg cat ctg cac cac cga ctg 336 Gly Ala Ser Pro Phe Ser Pro Asp Lys Met His Leu His His Arg Leu             100 105 110 ctg tcc atc gga cac acc cat agg cgc gtg gtc cta gtg ctc tac acc 384 Leu Ser Ile Gly His Thr His Arg Arg Val Val Leu Val Leu Tyr Thr         115 120 125 tgg gcg agc gcc gtg gca ttc ggc gca gtg agc ttc tcc gtc gtt ccg 432 Trp Ala Ser Ala Val Ala Phe Gly Ala Val Ser Phe Ser Val Val Pro     130 135 140 cca ctg ttt gcc acc gga tcg agc atc tgt ggc atc ctc atc gcc gtc 480 Pro Leu Phe Ala Thr Gly Ser Ser Ile Cys Gly Ile Leu Ile Ala Val 145 150 155 160 gct gtc aca gcc gtg cca gtg atg ag aaa agc cgg cga gcc gcc aaa ctt 528 Ala Val Thr Ala Val Pro Val Met Lys Ser Arg Arg Ala Ala Lys Leu                 165 170 175 gat taagtgattg tcactttgga ttg 554 Asp <210> 254 <211> 177 <212> PRT <213> Corynebacterium glutamicum <400> 254 Val Ser Ala Tyr Pro Pro Ala Ile Ile Ala Ala Ala Leu Val Gly Ile   1 5 10 15 Cys Ala Gly Val Leu Pro His Asn Phe Glu Pro Ser Arg Ile Phe Met              20 25 30 Gly Asp Ser Gly Ser Met Leu Ile Gly Leu Leu Leu Ala Ala Ala Ser          35 40 45 Thr Ser Ala Ser Gly Lys Ile Asn Met Ser Leu Tyr Gly Ala Ala Asp      50 55 60 Phe Ile Ala Leu Ile Ser Pro Ile Ile Val Val Leu Ala Ala Val Ala  65 70 75 80 Ile Pro Leu Leu Asp Leu Val Met Ala Val Val Arg Arg Val Gly Arg                  85 90 95 Gly Ala Ser Pro Phe Ser Pro Asp Lys Met His Leu His His Arg Leu             100 105 110 Leu Ser Ile Gly His Thr His Arg Arg Val Val Leu Val Leu Tyr Thr         115 120 125 Trp Ala Ser Ala Val Ala Phe Gly Ala Val Ser Phe Ser Val Val Pro     130 135 140 Pro Leu Phe Ala Thr Gly Ser Ser Ile Cys Gly Ile Leu Ile Ala Val 145 150 155 160 Ala Val Thr Ala Val Pro Val Met Lys Ser Arg Arg Ala Ala Lys Leu                 165 170 175 Asp <210> 255 <211> 882 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (859) <223> RXA01576 <400> 255 atcggtgatc tttcgcgatt gatacgtgcg cgattgcgtg cccgccagct gctcaagatc 60 aatggatttc atgacaatca agttatcatc actggggtcg gtg gca cct aac agg 115                                             Val Ala Pro Asn Arg                                               1 5 aaa atc agc cat cat gca cta ggc tct att cct atc atg gat gca tca 163 Lys Ile Ser His His Ala Leu Gly Ser Ile Pro Ile Met Asp Ala Ser                  10 15 20 aaa aac agc gac ttt aaa gac acc tgg cta gtc gta cct tgt tat aac 211 Lys Asn Ser Asp Phe Lys Asp Thr Trp Leu Val Val Pro Cys Tyr Asn              25 30 35 gag gca aca gtt atc cgg gaa gtt tta gag aac gca ctc aaa aca ttc 259 Glu Ala Thr Val Ile Arg Glu Val Leu Glu Asn Ala Leu Lys Thr Phe          40 45 50 cct aat att gtt gcg gtc aac gat ggc tcc ccg gac aac tcc gcg gaa 307 Pro Asn Ile Val Ala Val Asn Asp Gly Ser Pro Asp Asn Ser Ala Glu      55 60 65 gaa atc cat gcg gcc ggc gca cac ctg gtc aac cac ccc gtg aac ctc 355 Glu Ile His Ala Ala Gly Ala His Leu Val Asn His Pro Val Asn Leu  70 75 80 85 gga caa ggt gcc gcg atc caa acc ggc atc gaa tac gcc cgc aag caa 403 Gly Gln Gly Ala Ala Ile Gln Thr Gly Ile Glu Tyr Ala Arg Lys Gln                  90 95 100 ccc ggt gca aaa tac ttt gta act ttc gac gcc gac ggc caa cac caa 451 Pro Gly Ala Lys Tyr Phe Val Thr Phe Asp Ala Asp Gly Gln His Gln             105 110 115 gtg aaa gac gtt atc cgc atg gtg gag cga ctg cgt gcc gag gac gtg 499 Val Lys Asp Val Ile Arg Met Val Glu Arg Leu Arg Ala Glu Asp Val         120 125 130 gac att atc gtc ggc acg cgt ttt gga cgc cca cgc caa gcc gat gac 547 Asp Ile Ile Val Gly Thr Arg Phe Gly Arg Pro Arg Gln Ala Asp Asp     135 140 145 cag gtg cca cta atc aag cgc ctt gtg ctg cgc acc gtg gtc ctg ctg 595 Gln Val Pro Leu Ile Lys Arg Leu Val Leu Arg Thr Val Val Leu Leu 150 155 160 165 tca ccg aaa acc cgc cga ctt ggg ctc acc gac gcc cac aac ggc ctg 643 Ser Pro Lys Thr Arg Arg Leu Gly Leu Thr Asp Ala His Asn Gly Leu                 170 175 180 cgc gta ttc aac caa aaa gtg gcg cag gaa atg aac atc cgc atg aac 691 Arg Val Phe Asn Gln Lys Val Ala Gln Glu Met Asn Ile Arg Met Asn             185 190 195 ggc atg tcg cat gca tcc gaa atc gtc gac caa atc gat gaa cgc ggc 739 Gly Met Ser His Ala Ser Glu Ile Val Asp Gln Ile Asp Glu Arg Gly         200 205 210 tgg cgc att tca gaa gaa ccc gta gac atc ctc tac acc gaa tac tcc 787 Trp Arg Ile Ser Glu Glu Pro Val Asp Ile Leu Tyr Thr Glu Tyr Ser     215 220 225 atg agc aag ggg caa tcc ctg ctc aac ggc gta aac atc ctg gcc gac 835 Met Ser Lys Gly Gln Ser Leu Leu Asn Gly Val Asn Ile Leu Ala Asp 230 235 240 245 ggc ttc cta gcg agg aga ctc cca tgacgcagac caccacccaa atc 882 Gly Phe Leu Ala Arg Arg Leu Pro                 250 <210> 256 <211> 253 <212> PRT <213> Corynebacterium glutamicum <400> 256 Val Ala Pro Asn Arg Lys Ile Ser His His Ala Leu Gly Ser Ile Pro   1 5 10 15 Ile Met Asp Ala Ser Lys Asn Ser Asp Phe Lys Asp Thr Trp Leu Val              20 25 30 Val Pro Cys Tyr Asn Glu Ala Thr Val Ile Arg Glu Val Leu Glu Asn          35 40 45 Ala Leu Lys Thr Phe Pro Asn Ile Val Ala Val Asn Asp Gly Ser Pro      50 55 60 Asp Asn Ser Ala Glu Glu Ile His Ala Ala Gly Ala His Leu Val Asn  65 70 75 80 His Pro Val Asn Leu Gly Gln Gly Ala Ala Ile Gln Thr Gly Ile Glu                  85 90 95 Tyr Ala Arg Lys Gln Pro Gly Ala Lys Tyr Phe Val Thr Phe Asp Ala             100 105 110 Asp Gly Gln His Gln Val Lys Asp Val Ile Arg Met Val Glu Arg Leu         115 120 125 Arg Ala Glu Asp Val Asp Ile Ile Val Gly Thr Arg Phe Gly Arg Pro     130 135 140 Arg Gln Ala Asp Asp Gln Val Pro Leu Ile Lys Arg Leu Val Leu Arg 145 150 155 160 Thr Val Val Leu Leu Ser Pro Lys Thr Arg Arg Leu Gly Leu Thr Asp                 165 170 175 Ala His Asn Gly Leu Arg Val Phe Asn Gln Lys Val Ala Gln Glu Met             180 185 190 Asn Ile Arg Met Asn Gly Met Ser His Ala Ser Glu Ile Val Asp Gln         195 200 205 Ile Asp Glu Arg Gly Trp Arg Ile Ser Glu Glu Pro Val Asp Ile Leu     210 215 220 Tyr Thr Glu Tyr Ser Met Ser Lys Gly Gln Ser Leu Leu Asn Gly Val 225 230 235 240 Asn Ile Leu Ala Asp Gly Phe Leu Ala Arg Arg Leu Pro                 245 250 <210> 257 <211> 1173 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (1150) <223> RXN02309 <400> 257 gtgccttccg tcgactacgg ttaaacaaaa agctttttgt ccatttcact ggattcaccg 60 aaagaatgaa tccacactcg atcaccaaag gtagcgatga atg agt agc ggc cga 115                                             Met Ser Ser Gly Arg                                               1 5 acc gtt cca acc cgt tcc cac ggg ctc gga aaa gaa ggt gta tcc acc 163 Thr Val Pro Thr Arg Ser His Gly Leu Gly Lys Glu Gly Val Ser Thr                  10 15 20 aca gga gca tct cag gtc gag ttt ggt gat ccc gag cta acg gcc agg 211 Thr Gly Ala Ser Gln Val Glu Phe Gly Asp Pro Glu Leu Thr Ala Arg              25 30 35 atc aat gac gcc atg gtg cag gta gaa gaa ctc ctg cac act gaa cta 259 Ile Asn Asp Ala Met Val Gln Val Glu Glu Leu Leu His Thr Glu Leu          40 45 50 tcg tcc ggg gaa gac ttc ctc gtc gat atc gtc atg cac cta aca cga 307 Ser Ser Gly Glu Asp Phe Leu Val Asp Ile Val Met His Leu Thr Arg      55 60 65 gcc ggc ggc aaa cga ttc cgc ccc atg ttt gca ctg ctg gcc tcc gag 355 Ala Gly Gly Lys Arg Phe Arg Pro Met Phe Ala Leu Leu Ala Ser Glu  70 75 80 85 ttc ggt gaa aaa cca ctc tcc gaa aac gtc atc aaa gcc gcc gtt gtc 403 Phe Gly Glu Lys Pro Leu Ser Glu Asn Val Ile Lys Ala Ala Val Val                  90 95 100 gta gag atc acc cac ctg gcc acc ctg tac cac gac gat gtc atg gac 451 Val Glu Ile Thr His Leu Ala Thr Leu Tyr His Asp Asp Val Met Asp             105 110 115 gag gca tcc atg cgc cgc ggc gtc cca agt gct aac gcg cga tgg gac 499 Glu Ala Ser Met Arg Arg Gly Val Pro Ser Ala Asn Ala Arg Trp Asp         120 125 130 aac tcc gta gcc atc ctc gca ggc gac atc ctc cta gca cat gca tca 547 Asn Ser Val Ala Ile Leu Ala Gly Asp Ile Leu Leu Ala His Ala Ser     135 140 145 ggt ctg atg agt cag ctg ggt acc gac aca gtc gcc cac ttt gcc gaa 595 Gly Leu Met Ser Gln Leu Gly Thr Asp Thr Val Ala His Phe Ala Glu 150 155 160 165 aca ttc ggc gaa cta gtc acc ggc caa atg cgc gaa aca gtc ggg cca 643 Thr Phe Gly Glu Leu Val Thr Gly Gln Met Arg Glu Thr Val Gly Pro                 170 175 180 cgc gac acc gac ccg atc gag cac tac acc aac gta atc cgt gaa aaa 691 Arg Asp Thr Asp Pro Ile Glu His Tyr Thr Asn Val Ile Arg Glu Lys             185 190 195 act ggt gtc ctc atc gcc tcc gca ggc tat ttg gga gcc atg cac gca 739 Thr Gly Val Leu Ile Ala Ser Ala Gly Tyr Leu Gly Ala Met His Ala         200 205 210 ggc gcc gca cct gaa cac atc gac gcc ctg aag aac ttc ggc gca gcc 787 Gly Ala Ala Pro Glu His Ile Asp Ala Leu Lys Asn Phe Gly Ala Ala     215 220 225 gtc ggc atg atc ttc caa atc gtc gac gac atc atc gac atc ttc tcg 835 Val Gly Met Ile Phe Gln Ile Val Asp Asp Ile Ile Asp Ile Phe Ser 230 235 240 245 gaa acc cac gaa tcc gga aaa acg ccc ggc acc gac ctc cgc gaa ggt 883 Glu Thr His Glu Ser Gly Lys Thr Pro Gly Thr Asp Leu Arg Glu Gly                 250 255 260 gta ttc acc ctc cca gtg ctc tac gca ctc cgt gaa gac acc ccc gtc 931 Val Phe Thr Leu Pro Val Leu Tyr Ala Leu Arg Glu Asp Thr Pro Val             265 270 275 ggc gca gaa ctc cgc gac atc ctc acc ggc cct cta gaa gac gac gag 979 Gly Ala Glu Leu Arg Asp Ile Leu Thr Gly Pro Leu Glu Asp Asp Glu         280 285 290 acc gtc aac cac gtc ctc gag ctc ctc tcc caa tcc ggc gga cgc caa 1027 Thr Val Asn His Val Leu Glu Leu Leu Ser Gln Ser Gly Gly Arg Gln     295 300 305 gca gcc ctc gac gag gtc tac cgc tac atg gac atc gcc aac gca gaa 1075 Ala Ala Leu Asp Glu Val Tyr Arg Tyr Met Asp Ile Ala Asn Ala Glu 310 315 320 325 ctc gac cgc ctc cca gac agc acc gtc aag gaa gcc ctc cgc aac ctt 1123 Leu Asp Arg Leu Pro Asp Ser Thr Val Lys Glu Ala Leu Arg Asn Leu                 330 335 340 gca acc ttc aca gtc aag cgc gtc gga taaccccgta atccaccact 1170 Ala Thr Phe Thr Val Lys Arg Val Gly             345 350 taa 1173 <210> 258 <211> 350 <212> PRT <213> Corynebacterium glutamicum <400> 258 Met Ser Ser Gly Arg Thr Val Pro Thr Arg Ser His Gly Leu Gly Lys   1 5 10 15 Glu Gly Val Ser Thr Thr Gly Ala Ser Gln Val Glu Phe Gly Asp Pro              20 25 30 Glu Leu Thr Ala Arg Ile Asn Asp Ala Met Val Gln Val Glu Glu Leu          35 40 45 Leu His Thr Glu Leu Ser Ser Gly Glu Asp Phe Leu Val Asp Ile Val      50 55 60 Met His Leu Thr Arg Ala Gly Gly Lys Arg Phe Arg Pro Met Phe Ala  65 70 75 80 Leu Leu Ala Ser Glu Phe Gly Glu Lys Pro Leu Ser Glu Asn Val Ile                  85 90 95 Lys Ala Ala Val Val Val Glu Ile Thr His Leu Ala Thr Leu Tyr His             100 105 110 Asp Asp Val Met Asp Glu Ala Ser Met Arg Arg Gly Val Pro Ser Ala         115 120 125 Asn Ala Arg Trp Asp Asn Ser Val Ala Ile Leu Ala Gly Asp Ile Leu     130 135 140 Leu Ala His Ala Ser Gly Leu Met Ser Gln Leu Gly Thr Asp Thr Val 145 150 155 160 Ala His Phe Ala Glu Thr Phe Gly Glu Leu Val Thr Gly Gln Met Arg                 165 170 175 Glu Thr Val Gly Pro Arg Asp Thr Asp Pro Ile Glu His Tyr Thr Asn             180 185 190 Val Ile Arg Glu Lys Thr Gly Val Leu Ile Ala Ser Ala Gly Tyr Leu         195 200 205 Gly Ala Met His Ala Gly Ala Ala Pro Glu His Ile Asp Ala Leu Lys     210 215 220 Asn Phe Gly Ala Ala Val Gly Met Ile Phe Gln Ile Val Asp Asp Ile 225 230 235 240 Ile Asp Ile Phe Ser Glu Thr His Glu Ser Gly Lys Thr Pro Gly Thr                 245 250 255 Asp Leu Arg Glu Gly Val Phe Thr Leu Pro Val Leu Tyr Ala Leu Arg             260 265 270 Glu Asp Thr Pro Val Gly Ala Glu Leu Arg Asp Ile Leu Thr Gly Pro         275 280 285 Leu Glu Asp Asp Glu Thr Val Asn His Val Leu Glu Leu Leu Ser Gln     290 295 300 Ser Gly Gly Arg Gln Ala Ala Leu Asp Glu Val Tyr Arg Tyr Met Asp 305 310 315 320 Ile Ala Asn Ala Glu Leu Asp Arg Leu Pro Asp Ser Thr Val Lys Glu                 325 330 335 Ala Leu Arg Asn Leu Ala Thr Phe Thr Val Lys Arg Val Gly             340 345 350 <210> 259 <211> 1075 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (1075) <223> FRXA02309 <400> 259 gtgccttccg tcgactacgg ttaaacaaaa agctttttgt ccatttcact ggattcaccg 60 aaagaatgaa tccacactcg atcaccaaag gtagcgatga atg agt agc ggc cga 115                                             Met Ser Ser Gly Arg                                               1 5 acc gtt cca acc cgt tcc cac ggg ctc gga aaa gaa ggt gta tcc acc 163 Thr Val Pro Thr Arg Ser His Gly Leu Gly Lys Glu Gly Val Ser Thr                  10 15 20 aca gga gca tct cag gtc gag ttt ggt gat ccc gag cta acg gcc agg 211 Thr Gly Ala Ser Gln Val Glu Phe Gly Asp Pro Glu Leu Thr Ala Arg              25 30 35 atc aat gac gcc atg gtg cag gta gaa gaa ctc ctg cac act gaa cta 259 Ile Asn Asp Ala Met Val Gln Val Glu Glu Leu Leu His Thr Glu Leu          40 45 50 tcg tcc ggg gaa gac ttc ctc gtc gat atc gtc atg cac cta aca cga 307 Ser Ser Gly Glu Asp Phe Leu Val Asp Ile Val Met His Leu Thr Arg      55 60 65 gcc ggc ggc aaa cga ttc cgc ccc atg ttt gca ctg ctg gcc tcc gag 355 Ala Gly Gly Lys Arg Phe Arg Pro Met Phe Ala Leu Leu Ala Ser Glu  70 75 80 85 ttc ggt gaa aaa cca ctc tcc gaa aac gtc atc aaa gcc gcc gtt gtc 403 Phe Gly Glu Lys Pro Leu Ser Glu Asn Val Ile Lys Ala Ala Val Val                  90 95 100 gta gag atc acc cac ctg gcc acc ctg tac cac gac gat gtc atg gac 451 Val Glu Ile Thr His Leu Ala Thr Leu Tyr His Asp Asp Val Met Asp             105 110 115 gag gca tcc atg cgc cgc ggc gtc cca agt gct aac gcg cga tgg gac 499 Glu Ala Ser Met Arg Arg Gly Val Pro Ser Ala Asn Ala Arg Trp Asp         120 125 130 aac tcc gta gcc atc ctc gca ggc gac atc ctc cta gca cat gca tca 547 Asn Ser Val Ala Ile Leu Ala Gly Asp Ile Leu Leu Ala His Ala Ser     135 140 145 ggt ctg atg agt cag ctg ggt acc gac aca gtc gcc cac ttt gcc gaa 595 Gly Leu Met Ser Gln Leu Gly Thr Asp Thr Val Ala His Phe Ala Glu 150 155 160 165 aca ttc ggc gaa cta gtc acc ggc caa atg cgc gaa aca gtc ggg cca 643 Thr Phe Gly Glu Leu Val Thr Gly Gln Met Arg Glu Thr Val Gly Pro                 170 175 180 cgc gac acc gac ccg atc gag cac tac acc aac gta atc cgt gaa aaa 691 Arg Asp Thr Asp Pro Ile Glu His Tyr Thr Asn Val Ile Arg Glu Lys             185 190 195 act ggt gtc ctc atc gcc tcc gca ggc tat ttg gga gcc atg cac gca 739 Thr Gly Val Leu Ile Ala Ser Ala Gly Tyr Leu Gly Ala Met His Ala         200 205 210 ggc gcc gca cct gaa cac atc gac gcc ctg aag aac ttc ggc gca gcc 787 Gly Ala Ala Pro Glu His Ile Asp Ala Leu Lys Asn Phe Gly Ala Ala     215 220 225 gtc ggc atg atc ttc caa atc gtc gac gac atc atc gac atc ttc tcg 835 Val Gly Met Ile Phe Gln Ile Val Asp Asp Ile Ile Asp Ile Phe Ser 230 235 240 245 gaa acc cac gaa tcc gga aaa acg ccc ggc acc gac ctc cgc gaa ggt 883 Glu Thr His Glu Ser Gly Lys Thr Pro Gly Thr Asp Leu Arg Glu Gly                 250 255 260 gta ttc acc ctc cca gtg ctc tac gca ctc cgt gaa gac acc ccc gtc 931 Val Phe Thr Leu Pro Val Leu Tyr Ala Leu Arg Glu Asp Thr Pro Val             265 270 275 ggc gca gaa ctc cgc gac atc ctc acc ggc cct cta gaa gac gac gag 979 Gly Ala Glu Leu Arg Asp Ile Leu Thr Gly Pro Leu Glu Asp Asp Glu         280 285 290 acc gtc aac cac gtc ctc gag ctc ctc tcc caa tcc ggc gga cgc caa 1027 Thr Val Asn His Val Leu Glu Leu Leu Ser Gln Ser Gly Gly Arg Gln     295 300 305 gca gcc ctc gac gag gtc tac cgc tac atg gac atc gcc aac gca gaa 1075 Ala Ala Leu Asp Glu Val Tyr Arg Tyr Met Asp Ile Ala Asn Ala Glu 310 315 320 325 <210> 260 <211> 325 <212> PRT <213> Corynebacterium glutamicum <400> 260 Met Ser Ser Gly Arg Thr Val Pro Thr Arg Ser His Gly Leu Gly Lys   1 5 10 15 Glu Gly Val Ser Thr Thr Gly Ala Ser Gln Val Glu Phe Gly Asp Pro              20 25 30 Glu Leu Thr Ala Arg Ile Asn Asp Ala Met Val Gln Val Glu Glu Leu          35 40 45 Leu His Thr Glu Leu Ser Ser Gly Glu Asp Phe Leu Val Asp Ile Val      50 55 60 Met His Leu Thr Arg Ala Gly Gly Lys Arg Phe Arg Pro Met Phe Ala  65 70 75 80 Leu Leu Ala Ser Glu Phe Gly Glu Lys Pro Leu Ser Glu Asn Val Ile                  85 90 95 Lys Ala Ala Val Val Val Glu Ile Thr His Leu Ala Thr Leu Tyr His             100 105 110 Asp Asp Val Met Asp Glu Ala Ser Met Arg Arg Gly Val Pro Ser Ala         115 120 125 Asn Ala Arg Trp Asp Asn Ser Val Ala Ile Leu Ala Gly Asp Ile Leu     130 135 140 Leu Ala His Ala Ser Gly Leu Met Ser Gln Leu Gly Thr Asp Thr Val 145 150 155 160 Ala His Phe Ala Glu Thr Phe Gly Glu Leu Val Thr Gly Gln Met Arg                 165 170 175 Glu Thr Val Gly Pro Arg Asp Thr Asp Pro Ile Glu His Tyr Thr Asn             180 185 190 Val Ile Arg Glu Lys Thr Gly Val Leu Ile Ala Ser Ala Gly Tyr Leu         195 200 205 Gly Ala Met His Ala Gly Ala Ala Pro Glu His Ile Asp Ala Leu Lys     210 215 220 Asn Phe Gly Ala Ala Val Gly Met Ile Phe Gln Ile Val Asp Asp Ile 225 230 235 240 Ile Asp Ile Phe Ser Glu Thr His Glu Ser Gly Lys Thr Pro Gly Thr                 245 250 255 Asp Leu Arg Glu Gly Val Phe Thr Leu Pro Val Leu Tyr Ala Leu Arg             260 265 270 Glu Asp Thr Pro Val Gly Ala Glu Leu Arg Asp Ile Leu Thr Gly Pro         275 280 285 Leu Glu Asp Asp Glu Thr Val Asn His Val Leu Glu Leu Leu Ser Gln     290 295 300 Ser Gly Gly Arg Gln Ala Ala Leu Asp Glu Val Tyr Arg Tyr Met Asp 305 310 315 320 Ile Ala Asn Ala Glu                 325 <210> 261 <211> 1767 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1744) <223> RXN00477 <400> 261 tgcgggagcg aatcagagtt ccacttcata tcaaactctc tacactcgct agagccacga 60 tgaaaggtct atctatgagc atctacagaa agaattcgtg atg aag gtc tcg act 115                                             Met Lys Val Ser Thr                                               1 5 aaa act cca cgc tcc tca ggt acc gcc gta gtc ata ggc gca ggt gtt 163 Lys Thr Pro Arg Ser Ser Gly Thr Ala Val Val Ile Gly Ala Gly Val                  10 15 20 gct ggt tta gcc act tct gca ctt tta gca cgt gat ggc tgg caa gta 211 Ala Gly Leu Ala Thr Ser Ala Leu Leu Ala Arg Asp Gly Trp Gln Val              25 30 35 act gtt ttg gaa aaa aat act gat gtc ggt ggc cga gct gga tcg ctt 259 Thr Val Leu Glu Lys Asn Thr Asp Val Gly Gly Arg Ala Gly Ser Leu          40 45 50 gaa ata tca ggc ttt cct ggc ttt cga tgg gat acc gga cct tct tgg 307 Glu Ile Ser Gly Phe Pro Gly Phe Arg Trp Asp Thr Gly Pro Ser Trp      55 60 65 tac ctc atg ccc gag gcc ttt gac cat ttc ttc gca ctt ttt ggt gca 355 Tyr Leu Met Pro Glu Ala Phe Asp His Phe Phe Ala Leu Phe Gly Ala  70 75 80 85 tgt act tct gat tat ctc gat ttg gta gaa tta acg cct ggt tat cga 403 Cys Thr Ser Asp Tyr Leu Asp Leu Val Glu Leu Thr Pro Gly Tyr Arg                  90 95 100 gtt ttt tct ggc aca cat gac gct gtc gat gtc ccc act ggg cgt gaa 451 Val Phe Ser Gly Thr His Asp Ala Val Asp Val Pro Thr Gly Arg Glu             105 110 115 gaa gca att gcg cta ttc gaa tcc atc gaa ccc ggc gcg ggt gca aaa 499 Glu Ala Ile Ala Leu Phe Glu Ser Ile Glu Pro Gly Ala Gly Ala Lys         120 125 130 cta gga aat tat ctt gat agc gcg gca gac gcc tat gac att gcc att 547 Leu Gly Asn Tyr Leu Asp Ser Ala Ala Asp Ala Tyr Asp Ile Ala Ile     135 140 145 gat aga ttc ctt tat aat aat ttc tcc acg tta ggc ccg ctg ctt cac 595 Asp Arg Phe Leu Tyr Asn Asn Phe Ser Thr Leu Gly Pro Leu Leu His 150 155 160 165 cgg gat gta ctg acc cga gct ggc cga ctg ttt tct cta ctg acc cgt 643 Arg Asp Val Leu Thr Arg Ala Gly Arg Leu Phe Ser Leu Leu Thr Arg                 170 175 180 tct tta caa aag tac gta aat agt caa ttc agt agc ccg gtg ttg cgc 691 Ser Leu Gln Lys Tyr Val Asn Ser Gln Phe Ser Ser Pro Val Leu Arg             185 190 195 cag atc cta acc tat cca gca gtc ttc ctg tct tcc cga ccc act act 739 Gln Ile Leu Thr Tyr Pro Ala Val Phe Leu Ser Ser Arg Pro Thr Thr         200 205 210 acc cca tcg atg tac cac ttg atg agt cat acc gat ttg gtg cag gga 787 Thr Pro Ser Met Tyr His Leu Met Ser His Thr Asp Leu Val Gln Gly     215 220 225 gtg aaa tac cct ata ggt ggt ttt act gca gtg gtt aac gct ctg cat 835 Val Lys Tyr Pro Ile Gly Gly Phe Thr Ala Val Val Asn Ala Leu His 230 235 240 245 cag tta gcg ctg gaa aac ggg gtt gag ttt caa ctc gat tct gag gtc 883 Gln Leu Ala Leu Glu Asn Gly Val Glu Phe Gln Leu Asp Ser Glu Val                 250 255 260 att tcc atc aac act gct tca tcg agg ggc aac aca agc gcc aca ggt 931 Ile Ser Ile Asn Thr Ala Ser Ser Arg Gly Asn Thr Ser Ala Thr Gly             265 270 275 gtg agc ttg ctt cac aac aga aaa gtg caa aat cta gat gcg gat ctt 979 Val Ser Leu Leu His Asn Arg Lys Val Gln Asn Leu Asp Ala Asp Leu         280 285 290 gtg gtt tca gca ggc gac cta cac cat aca gaa aat aat ctg ctt ccc 1027 Val Val Ser Ala Gly Asp Leu His His Thr Glu Asn Asn Leu Leu Pro     295 300 305 cgg gaa ctt cga acc tat ccc gaa cga tat tgg tcc aat cgc aat cct 1075 Arg Glu Leu Arg Thr Tyr Pro Glu Arg Tyr Trp Ser Asn Arg Asn Pro 310 315 320 325 gga att gga gcg gta tta atc ctc ctg ggc gta aaa gga gag tta ccc 1123 Gly Ile Gly Ala Val Leu Ile Leu Leu Gly Val Lys Gly Glu Leu Pro                 330 335 340 cag ctc gac cat cac aac ctt ttc ttc agt gaa gat tgg aca gat gat 1171 Gln Leu Asp His His Asn Leu Phe Phe Ser Glu Asp Trp Thr Asp Asp             345 350 355 ttt gct gta gtt ttc gac ggg cct caa ctt acc cgc ccc cac aat gca 1219 Phe Ala Val Val Phe Asp Gly Pro Gln Leu Thr Arg Pro His Asn Ala         360 365 370 tca aat tcc att tat gtc tcc aag cct tca acg tcc gaa gac ggc gtt 1267 Ser Asn Ser Ile Tyr Val Ser Lys Pro Ser Thr Ser Glu Asp Gly Val     375 380 385 gca cct gct gga tac gaa aac ctt ttt gtt tta att ccg acc aag gcc 1315 Ala Pro Ala Gly Tyr Glu Asn Leu Phe Val Leu Ile Pro Thr Lys Ala 390 395 400 405 tct agc agc atc ggc cac ggt gat gcg tat atg cag tcg gct tca gca 1363 Ser Ser Ser Ile Gly His Gly Asp Ala Tyr Met Gln Ser Ala Ser Ala                 410 415 420 tcc gtg gaa aca atc gcg tca cat gca atc aat caa att gct acg caa 1411 Ser Val Glu Thr Ile Ala Ser His Ala Ile Asn Gln Ile Ala Thr Gln             425 430 435 gcc ggc atc cct gac ctc act gac cga att gtg gtc aaa cgc acc att 1459 Ala Gly Ile Pro Asp Leu Thr Asp Arg Ile Val Val Lys Arg Thr Ile         440 445 450 ggc cct gcg gat ttt gag cac cgc tac cat tca tgg gta ggc agt gcg 1507 Gly Pro Ala Asp Phe Glu His Arg Tyr His Ser Trp Val Gly Ser Ala     455 460 465 ctg ggt cca gca cat acc ctc aga cag tcc gct ttc tta aga ggg cgc 1555 Leu Gly Pro Ala His Thr Leu Arg Gln Ser Ala Phe Leu Arg Gly Arg 470 475 480 485 aat agc tcc cgc aag gtc aat aac ctc ttc tat tcc ggt gcc acc acc 1603 Asn Ser Ser Arg Lys Val Asn Asn Leu Phe Tyr Ser Gly Ala Thr Thr                 490 495 500 gtc ccg ggt gta gga ata ccc atg tgt tta att tct gcc gag aat att 1651 Val Pro Gly Val Gly Ile Pro Met Cys Leu Ile Ser Ala Glu Asn Ile             505 510 515 att aag cgt tta cat gcc gat acc agt gca gga cca ctg ccc gaa cca 1699 Ile Lys Arg Leu His Ala Asp Thr Ser Ala Gly Pro Leu Pro Glu Pro         520 525 530 ttg ccg cct aaa acg aca cca tct caa aag acc tca tac gat cat 1744 Leu Pro Pro Lys Thr Thr Pro Ser Gln Lys Thr Ser Tyr Asp His     535 540 545 taaattttga tccctatcat cga 1767 <210> 262 <211> 548 <212> PRT <213> Corynebacterium glutamicum <400> 262 Met Lys Val Ser Thr Lys Thr Pro Arg Ser Ser Gly Thr Ala Val Val   1 5 10 15 Ile Gly Ala Gly Val Ala Gly Leu Ala Thr Ser Ala Leu Leu Ala Arg              20 25 30 Asp Gly Trp Gln Val Thr Val Leu Glu Lys Asn Thr Asp Val Gly Gly          35 40 45 Arg Ala Gly Ser Leu Glu Ile Ser Gly Phe Pro Gly Phe Arg Trp Asp      50 55 60 Thr Gly Pro Ser Trp Tyr Leu Met Pro Glu Ala Phe Asp His Phe Phe  65 70 75 80 Ala Leu Phe Gly Ala Cys Thr Ser Asp Tyr Leu Asp Leu Val Glu Leu                  85 90 95 Thr Pro Gly Tyr Arg Val Phe Ser Gly Thr His Asp Ala Val Asp Val             100 105 110 Pro Thr Gly Arg Glu Glu Ala Ile Ala Leu Phe Glu Ser Ile Glu Pro         115 120 125 Gly Ala Gly Ala Lys Leu Gly Asn Tyr Leu Asp Ser Ala Ala Asp Ala     130 135 140 Tyr Asp Ile Ala Ile Asp Arg Phe Leu Tyr Asn Asn Phe Ser Thr Leu 145 150 155 160 Gly Pro Leu Leu His Arg Asp Val Leu Thr Arg Ala Gly Arg Leu Phe                 165 170 175 Ser Leu Leu Thr Arg Ser Leu Gln Lys Tyr Val Asn Ser Gln Phe Ser             180 185 190 Ser Pro Val Leu Arg Gln Ile Leu Thr Tyr Pro Ala Val Phe Leu Ser         195 200 205 Ser Arg Pro Thr Thr Thr Pro Pro Ser Met Tyr His Leu Met Ser His Thr     210 215 220 Asp Leu Val Gln Gly Val Lys Tyr Pro Ile Gly Gly Phe Thr Ala Val 225 230 235 240 Val Asn Ala Leu His Gln Leu Ala Leu Glu Asn Gly Val Glu Phe Gln                 245 250 255 Leu Asp Ser Glu Val Ile Ser Ile Asn Thr Ala Ser Ser Arg Gly Asn             260 265 270 Thr Ser Ala Thr Gly Val Ser Leu Leu His Asn Arg Lys Val Gln Asn         275 280 285 Leu Asp Ala Asp Leu Val Val Ser Ala Gly Asp Leu His His Thr Glu     290 295 300 Asn Asn Leu Leu Pro Arg Glu Leu Arg Thr Tyr Pro Glu Arg Tyr Trp 305 310 315 320 Ser Asn Arg Asn Pro Gly Ile Gly Ala Val Leu Ile Leu Leu Gly Val                 325 330 335 Lys Gly Glu Leu Pro Gln Leu Asp His His Asn Leu Phe Phe Ser Glu             340 345 350 Asp Trp Thr Asp Asp Phe Ala Val Val Phe Asp Gly Pro Gln Leu Thr         355 360 365 Arg Pro His Asn Ala Ser Asn Ser Ile Tyr Val Ser Lys Pro Ser Thr     370 375 380 Ser Glu Asp Gly Val Ala Pro Ala Gly Tyr Glu Asn Leu Phe Val Leu 385 390 395 400 Ile Pro Thr Lys Ala Ser Ser Ser Ile Gly His Gly Asp Ala Tyr Met                 405 410 415 Gln Ser Ala Ser Ala Ser Val Glu Thr Ile Ala Ser His Ala Ile Asn             420 425 430 Gln Ile Ala Thr Gln Ala Gly Ile Pro Asp Leu Thr Asp Arg Ile Val         435 440 445 Val Lys Arg Thr Ile Gly Pro Ala Asp Phe Glu His Arg Tyr His Ser     450 455 460 Trp Val Gly Ser Ala Leu Gly Pro Ala His Thr Leu Arg Gln Ser Ala 465 470 475 480 Phe Leu Arg Gly Arg Asn Ser Ser Arg Lys Val Asn Asn Leu Phe Tyr                 485 490 495 Ser Gly Ala Thr Thr Val Pro Gly Val Gly Ile Pro Met Cys Leu Ile             500 505 510 Ser Ala Glu Asn Ile Ile Lys Arg Leu His Ala Asp Thr Ser Ala Gly         515 520 525 Pro Leu Pro Glu Pro Leu Pro Pro Lys Thr Thr Pro Ser Gln Lys Thr     530 535 540 Ser Tyr Asp His 545 <210> 263 <211> 1767 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1744) <223> FRXA00477 <400> 263 tgcgggagcg aatcagagtt ccacttcata tcaaactctc tacactcgct agagccacga 60 tgaaaggtct atctatgagc atctacagaa agaattcgtg atg aag gtc tcg act 115                                             Met Lys Val Ser Thr                                               1 5 aaa act cca cgc tcc tca ggt acc gcc gta gtc ata ggc gca ggt gtt 163 Lys Thr Pro Arg Ser Ser Gly Thr Ala Val Val Ile Gly Ala Gly Val                  10 15 20 gct ggt tta gcc act tct gca ctt tta gca cgt gat ggc tgg caa gta 211 Ala Gly Leu Ala Thr Ser Ala Leu Leu Ala Arg Asp Gly Trp Gln Val              25 30 35 act gtt ttg gaa aaa aat act gat gtc ggt ggc cga gct gga tcg ctt 259 Thr Val Leu Glu Lys Asn Thr Asp Val Gly Gly Arg Ala Gly Ser Leu          40 45 50 gaa ata tca ggc ttt cct ggc ttt cga tgg gat acc gga cct tct tgg 307 Glu Ile Ser Gly Phe Pro Gly Phe Arg Trp Asp Thr Gly Pro Ser Trp      55 60 65 tac ctc atg ccc gag gcc ttt gac cat ttc ttc gca ctt ttt ggt gca 355 Tyr Leu Met Pro Glu Ala Phe Asp His Phe Phe Ala Leu Phe Gly Ala  70 75 80 85 tgt act tct gat tat ctc gat ttg gta gaa tta acg cct ggt tat cga 403 Cys Thr Ser Asp Tyr Leu Asp Leu Val Glu Leu Thr Pro Gly Tyr Arg                  90 95 100 gtt ttt tct ggc aca cat gac gct gtc gat gtc ccc act ggg cgt gaa 451 Val Phe Ser Gly Thr His Asp Ala Val Asp Val Pro Thr Gly Arg Glu             105 110 115 gaa gca att gcg cta ttc gaa tcc atc gaa ccc ggc gcg ggt gca aaa 499 Glu Ala Ile Ala Leu Phe Glu Ser Ile Glu Pro Gly Ala Gly Ala Lys         120 125 130 cta gga aat tat ctt gat agc gcg gca gac gcc tat gac att gcc att 547 Leu Gly Asn Tyr Leu Asp Ser Ala Ala Asp Ala Tyr Asp Ile Ala Ile     135 140 145 gat aga ttc ctt tat aat aat ttc tcc acg tta ggc ccg ctg ctt cac 595 Asp Arg Phe Leu Tyr Asn Asn Phe Ser Thr Leu Gly Pro Leu Leu His 150 155 160 165 cgg gat gta ctg acc cga gct ggc cga ctg ttt tct cta ctg acc cgt 643 Arg Asp Val Leu Thr Arg Ala Gly Arg Leu Phe Ser Leu Leu Thr Arg                 170 175 180 tct tta caa aag tac gta aat agt caa ttc agt agc ccg gtg ttg cgc 691 Ser Leu Gln Lys Tyr Val Asn Ser Gln Phe Ser Ser Pro Val Leu Arg             185 190 195 cag atc cta acc tat cca gca gtc ttc ctg tct tcc cga ccc act act 739 Gln Ile Leu Thr Tyr Pro Ala Val Phe Leu Ser Ser Arg Pro Thr Thr         200 205 210 acc cca tcg atg tac cac ttg atg agt cat acc gat ttg gtg cag gga 787 Thr Pro Ser Met Tyr His Leu Met Ser His Thr Asp Leu Val Gln Gly     215 220 225 gtg aaa tac cct ata ggt ggt ttt act gca gtg gtt aac gct ctg cat 835 Val Lys Tyr Pro Ile Gly Gly Phe Thr Ala Val Val Asn Ala Leu His 230 235 240 245 cag tta gcg ctg gaa aac ggg gtt gag ttt caa ctc gat tct gag gtc 883 Gln Leu Ala Leu Glu Asn Gly Val Glu Phe Gln Leu Asp Ser Glu Val                 250 255 260 att tcc atc aac act gct tca tcg agg ggc aac aca agc gcc aca ggt 931 Ile Ser Ile Asn Thr Ala Ser Ser Arg Gly Asn Thr Ser Ala Thr Gly             265 270 275 gtg agc ttg ctt cac aac aga aaa gtg caa aat cta gat gcg gat ctt 979 Val Ser Leu Leu His Asn Arg Lys Val Gln Asn Leu Asp Ala Asp Leu         280 285 290 gtg gtt tca gca ggc gac cta cac cat aca gaa aat aat ctg ctt ccc 1027 Val Val Ser Ala Gly Asp Leu His His Thr Glu Asn Asn Leu Leu Pro     295 300 305 cgg gaa ctt cga acc tat ccc gaa cga tat tgg tcc aat cgc aat cct 1075 Arg Glu Leu Arg Thr Tyr Pro Glu Arg Tyr Trp Ser Asn Arg Asn Pro 310 315 320 325 gga att gga gcg gta tta atc ctc ctg ggc gta aaa gga gag tta ccc 1123 Gly Ile Gly Ala Val Leu Ile Leu Leu Gly Val Lys Gly Glu Leu Pro                 330 335 340 cag ctc gac cat cac aac ctt ttc ttc agt gaa gat tgg aca gat gat 1171 Gln Leu Asp His His Asn Leu Phe Phe Ser Glu Asp Trp Thr Asp Asp             345 350 355 ttt gct gta gtt ttc gac ggg cct caa ctt acc cgc ccc cac aat gca 1219 Phe Ala Val Val Phe Asp Gly Pro Gln Leu Thr Arg Pro His Asn Ala         360 365 370 tca aat tcc att tat gtc tcc aag cct tca acg tcc gaa gac ggc gtt 1267 Ser Asn Ser Ile Tyr Val Ser Lys Pro Ser Thr Ser Glu Asp Gly Val     375 380 385 gca cct gct gga tac gaa aac ctt ttt gtt tta att ccg acc aag gcc 1315 Ala Pro Ala Gly Tyr Glu Asn Leu Phe Val Leu Ile Pro Thr Lys Ala 390 395 400 405 tct agc agc atc ggc cac ggt gat gcg tat atg cag tcg gct tca gca 1363 Ser Ser Ser Ile Gly His Gly Asp Ala Tyr Met Gln Ser Ala Ser Ala                 410 415 420 tcc gtg gaa aca atc gcg tca cat gca atc aat caa att gct acg caa 1411 Ser Val Glu Thr Ile Ala Ser His Ala Ile Asn Gln Ile Ala Thr Gln             425 430 435 gcc ggc atc cct gac ctc act gac cga att gtg gtc aaa cgc acc att 1459 Ala Gly Ile Pro Asp Leu Thr Asp Arg Ile Val Val Lys Arg Thr Ile         440 445 450 ggc cct gcg gat ttt gag cac cgc tac cat tca tgg gta ggc agt gcg 1507 Gly Pro Ala Asp Phe Glu His Arg Tyr His Ser Trp Val Gly Ser Ala     455 460 465 ctg ggt cca gca cat acc ctc aga cag tcc gct ttc tta aga ggg cgc 1555 Leu Gly Pro Ala His Thr Leu Arg Gln Ser Ala Phe Leu Arg Gly Arg 470 475 480 485 aat agc tcc cgc aag gtc aat aac ctc ttc tat tcc ggt gcc acc acc 1603 Asn Ser Ser Arg Lys Val Asn Asn Leu Phe Tyr Ser Gly Ala Thr Thr                 490 495 500 gtc ccg ggt gta gga ata ccc atg tgt tta att tct gcc gag aat att 1651 Val Pro Gly Val Gly Ile Pro Met Cys Leu Ile Ser Ala Glu Asn Ile             505 510 515 att aag cgt tta cat gcc gat acc agt gca gga cca ctg ccc gaa cca 1699 Ile Lys Arg Leu His Ala Asp Thr Ser Ala Gly Pro Leu Pro Glu Pro         520 525 530 ttg ccg cct aaa acg aca cca tct caa aag acc tca tac gat cat 1744 Leu Pro Pro Lys Thr Thr Pro Ser Gln Lys Thr Ser Tyr Asp His     535 540 545 taaattttga tccctatcat cga 1767 <210> 264 <211> 548 <212> PRT <213> Corynebacterium glutamicum <400> 264 Met Lys Val Ser Thr Lys Thr Pro Arg Ser Ser Gly Thr Ala Val Val   1 5 10 15 Ile Gly Ala Gly Val Ala Gly Leu Ala Thr Ser Ala Leu Leu Ala Arg              20 25 30 Asp Gly Trp Gln Val Thr Val Leu Glu Lys Asn Thr Asp Val Gly Gly          35 40 45 Arg Ala Gly Ser Leu Glu Ile Ser Gly Phe Pro Gly Phe Arg Trp Asp      50 55 60 Thr Gly Pro Ser Trp Tyr Leu Met Pro Glu Ala Phe Asp His Phe Phe  65 70 75 80 Ala Leu Phe Gly Ala Cys Thr Ser Asp Tyr Leu Asp Leu Val Glu Leu                  85 90 95 Thr Pro Gly Tyr Arg Val Phe Ser Gly Thr His Asp Ala Val Asp Val             100 105 110 Pro Thr Gly Arg Glu Glu Ala Ile Ala Leu Phe Glu Ser Ile Glu Pro         115 120 125 Gly Ala Gly Ala Lys Leu Gly Asn Tyr Leu Asp Ser Ala Ala Asp Ala     130 135 140 Tyr Asp Ile Ala Ile Asp Arg Phe Leu Tyr Asn Asn Phe Ser Thr Leu 145 150 155 160 Gly Pro Leu Leu His Arg Asp Val Leu Thr Arg Ala Gly Arg Leu Phe                 165 170 175 Ser Leu Leu Thr Arg Ser Leu Gln Lys Tyr Val Asn Ser Gln Phe Ser             180 185 190 Ser Pro Val Leu Arg Gln Ile Leu Thr Tyr Pro Ala Val Phe Leu Ser         195 200 205 Ser Arg Pro Thr Thr Thr Pro Pro Ser Met Tyr His Leu Met Ser His Thr     210 215 220 Asp Leu Val Gln Gly Val Lys Tyr Pro Ile Gly Gly Phe Thr Ala Val 225 230 235 240 Val Asn Ala Leu His Gln Leu Ala Leu Glu Asn Gly Val Glu Phe Gln                 245 250 255 Leu Asp Ser Glu Val Ile Ser Ile Asn Thr Ala Ser Ser Arg Gly Asn             260 265 270 Thr Ser Ala Thr Gly Val Ser Leu Leu His Asn Arg Lys Val Gln Asn         275 280 285 Leu Asp Ala Asp Leu Val Val Ser Ala Gly Asp Leu His His Thr Glu     290 295 300 Asn Asn Leu Leu Pro Arg Glu Leu Arg Thr Tyr Pro Glu Arg Tyr Trp 305 310 315 320 Ser Asn Arg Asn Pro Gly Ile Gly Ala Val Leu Ile Leu Leu Gly Val                 325 330 335 Lys Gly Glu Leu Pro Gln Leu Asp His His Asn Leu Phe Phe Ser Glu             340 345 350 Asp Trp Thr Asp Asp Phe Ala Val Val Phe Asp Gly Pro Gln Leu Thr         355 360 365 Arg Pro His Asn Ala Ser Asn Ser Ile Tyr Val Ser Lys Pro Ser Thr     370 375 380 Ser Glu Asp Gly Val Ala Pro Ala Gly Tyr Glu Asn Leu Phe Val Leu 385 390 395 400 Ile Pro Thr Lys Ala Ser Ser Ser Ile Gly His Gly Asp Ala Tyr Met                 405 410 415 Gln Ser Ala Ser Ala Ser Val Glu Thr Ile Ala Ser His Ala Ile Asn             420 425 430 Gln Ile Ala Thr Gln Ala Gly Ile Pro Asp Leu Thr Asp Arg Ile Val         435 440 445 Val Lys Arg Thr Ile Gly Pro Ala Asp Phe Glu His Arg Tyr His Ser     450 455 460 Trp Val Gly Ser Ala Leu Gly Pro Ala His Thr Leu Arg Gln Ser Ala 465 470 475 480 Phe Leu Arg Gly Arg Asn Ser Ser Arg Lys Val Asn Asn Leu Phe Tyr                 485 490 495 Ser Gly Ala Thr Thr Val Pro Gly Val Gly Ile Pro Met Cys Leu Ile             500 505 510 Ser Ala Glu Asn Ile Ile Lys Arg Leu His Ala Asp Thr Ser Ala Gly         515 520 525 Pro Leu Pro Glu Pro Leu Pro Pro Lys Thr Thr Pro Ser Gln Lys Thr     530 535 540 Ser Tyr Asp His 545 <210> 265 <211> 954 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (931) <223> RXA00478 <400> 265 accagaagca gcctcagcta tgacacacca aaattcgcct ctcttcctta aaagtgcact 60 gagactttac aatcgggcct cattcaaggc ttcacataaa gtg atc gaa gaa tat 115                                             Val Ile Glu Glu Tyr                                               1 5 tcc acg agc ttc agt ctg tct acg tgg ttg cta tcc cca cgc ata cga 163 Ser Thr Ser Phe Ser Leu Ser Thr Trp Leu Leu Ser Pro Arg Ile Arg                  10 15 20 aat gac ata cga aat ctc tat gca gta gtt cgt atc gcc gat gag att 211 Asn Asp Ile Arg Asn Leu Tyr Ala Val Val Arg Ile Ala Asp Glu Ile              25 30 35 gtc gac ggc act gca cat gcc gct ggt tgc tca act gcc aaa atc gaa 259 Val Asp Gly Thr Ala His Ala Ala Gly Cys Ser Thr Ala Lys Ile Glu          40 45 50 gag att ctc gat gcc tat gaa att gcg gtt ctt gca gca cca caa caa 307 Glu Ile Leu Asp Ala Tyr Glu Ile Ala Val Leu Ala Ala Pro Gln Gln      55 60 65 cgc ttc aac aca gat ctt gtt tta caa gct tat ggt gaa act gcc cga 355 Arg Phe Asn Thr Asp Leu Val Leu Gln Ala Tyr Gly Glu Thr Ala Arg  70 75 80 85 cgc tgt gat ttc gaa caa gag cat gta ata gcc ttc ttt gca tca atg 403 Arg Cys Asp Phe Glu Gln Glu His Val Ile Ala Phe Phe Ala Ser Met                  90 95 100 cgt aag gac ctc aaa gct aat aca cac gac cca gat agc ttc aca acg 451 Arg Lys Asp Leu Lys Ala Asn Thr His Asp Pro Asp Ser Phe Thr Thr             105 110 115 tat gtc tat ggc tcc gcg gaa gtt ata ggc ctg ctt tgt ctc agc gtt 499 Tyr Val Tyr Gly Ser Ala Glu Val Ile Gly Leu Leu Cys Leu Ser Val         120 125 130 ttc aac caa ggt aga acg att agc aaa aaa cgg cta gag att atg caa 547 Phe Asn Gln Gly Arg Thr Ile Ser Lys Lys Arg Leu Glu Ile Met Gln     135 140 145 aac gga gcc cgc tca ttg gga gcg gca ttc cag aaa att aac ttt ctc 595 Asn Gly Ala Arg Ser Leu Gly Ala Ala Phe Gln Lys Ile Asn Phe Leu 150 155 160 165 cgt gac ttg gca gaa gat cag caa aat ttg ggc cga ttt tat ttc ccc 643 Arg Asp Leu Ala Glu Asp Gln Gln Asn Leu Gly Arg Phe Tyr Phe Pro                 170 175 180 aaa acc agc caa gga act ctt act aaa gaa caa aaa gaa gat ctc atc 691 Lys Thr Ser Gln Gly Thr Leu Thr Lys Glu Gln Lys Glu Asp Leu Ile             185 190 195 gct gat atc cgt caa gac cta gca att gcc cac gat gca ttt cca gaa 739 Ala Asp Ile Arg Gln Asp Leu Ala Ile Ala His Asp Ala Phe Pro Glu         200 205 210 ata cca gtg cag gct cgc atc gga gtg atc tct gct tat ttg ctc ttt 787 Ile Pro Val Gln Ala Arg Ile Gly Val Ile Ser Ala Tyr Leu Leu Phe     215 220 225 caa aaa ctc act gac cga att gag gct act cct acc gcc gat tta ttg 835 Gln Lys Leu Thr Asp Arg Ile Glu Ala Thr Pro Thr Ala Asp Leu Leu 230 235 240 245 cgg gag cga atc aga gtt cca ctt cat atc aaa ctc tct aca ctc gct 883 Arg Glu Arg Ile Arg Val Pro Leu His Ile Lys Leu Ser Thr Leu Ala                 250 255 260 aga gcc acg atg aaa ggt cta tct atg agc atc tac aga aag aat tcg 931 Arg Ala Thr Met Lys Gly Leu Ser Met Ser Ile Tyr Arg Lys Asn Ser             265 270 275 tgatgaaggt ctcgactaaa act 954 <210> 266 <211> 277 <212> PRT <213> Corynebacterium glutamicum <400> 266 Val Ile Glu Glu Tyr Ser Thr Ser Phe Ser Leu Ser Thr Trp Leu Leu   1 5 10 15 Ser Pro Arg Ile Arg Asn Asp Ile Arg Asn Leu Tyr Ala Val Val Arg              20 25 30 Ile Ala Asp Glu Ile Val Asp Gly Thr Ala His Ala Ala Gly Cys Ser          35 40 45 Thr Ala Lys Ile Glu Glu Ile Leu Asp Ala Tyr Glu Ile Ala Val Leu      50 55 60 Ala Ala Pro Gln Gln Arg Phe Asn Thr Asp Leu Val Leu Gln Ala Tyr  65 70 75 80 Gly Glu Thr Ala Arg Arg Cys Asp Phe Glu Gln Glu His Val Ile Ala                  85 90 95 Phe Phe Ala Ser Met Arg Lys Asp Leu Lys Ala Asn Thr His Asp Pro             100 105 110 Asp Ser Phe Thr Thr Tyr Val Tyr Gly Ser Ala Glu Val Ile Gly Leu         115 120 125 Leu Cys Leu Ser Val Phe Asn Gln Gly Arg Thr Ile Ser Lys Lys Arg     130 135 140 Leu Glu Ile Met Gln Asn Gly Ala Arg Ser Leu Gly Ala Ala Phe Gln 145 150 155 160 Lys Ile Asn Phe Leu Arg Asp Leu Ala Glu Asp Gln Gln Asn Leu Gly                 165 170 175 Arg Phe Tyr Phe Pro Lys Thr Ser Gln Gly Thr Leu Thr Lys Glu Gln             180 185 190 Lys Glu Asp Leu Ile Ala Asp Ile Arg Gln Asp Leu Ala Ile Ala His         195 200 205 Asp Ala Phe Pro Glu Ile Pro Val Gln Ala Arg Ile Gly Val Ile Ser     210 215 220 Ala Tyr Leu Leu Phe Gln Lys Leu Thr Asp Arg Ile Glu Ala Thr Pro 225 230 235 240 Thr Ala Asp Leu Leu Arg Glu Arg Ile Arg Val Pro Leu His Ile Lys                 245 250 255 Leu Ser Thr Leu Ala Arg Ala Thr Met Lys Gly Leu Ser Met Ser Ile             260 265 270 Tyr Arg Lys Asn Ser         275 <210> 267 <211> 1056 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1033) <223> RXA01291 <400> 267 aacccgcagc gggtggagcg gggctgaggg agacgtcgag aagcgtccct ttcggttgtc 60 tggatttctc gcggtaaagt ttcctgtgaa ggaggcgagt gtg gct gat cag caa 115                                             Val Ala Asp Gln Gln                                               1 5 gat ttt ttg ggc cgt ttt gat gcg atg agc tca aag gcg acg gcc acg 163 Asp Phe Leu Gly Arg Phe Asp Ala Met Ser Ser Lys Ala Thr Ala Thr                  10 15 20 gta atc gcc cat tat tcc tcc agt ttt act ctg gca tcg aag ctg ttg 211 Val Ile Ala His Tyr Ser Ser Ser Phe Thr Leu Ala Ser Lys Leu Leu              25 30 35 tcg ccg aaa att cgt cgc gat att gag gca ttg tac gca atg gtg cga 259 Ser Pro Lys Ile Arg Arg Asp Ile Glu Ala Leu Tyr Ala Met Val Arg          40 45 50 gtg gcc gat gag gtt gtg gac ggc gct gct gct gcc gcg ggg tgt gcg 307 Val Ala Asp Glu Val Val Asp Gly Ala Ala Ala Ala Ala Gly Cys Ala      55 60 65 ccg gac gcc gtt gcg gag att ttg gac aat tac gaa cgc cag gtt ctg 355 Pro Asp Ala Val Ala Glu Ile Leu Asp Asn Tyr Glu Arg Gln Val Leu  70 75 80 85 ctc agt ttg tcc gtt cct ttt cat acc gat cca gtg atc cat gcg ttt 403 Leu Ser Leu Ser Val Pro Phe His Thr Asp Pro Val Ile His Ala Phe                  90 95 100 ggc aat acc gcc cgc aaa tgt ggt ttt gag cag gct cac atc gtg gcg 451 Gly Asn Thr Ala Arg Lys Cys Gly Phe Glu Gln Ala His Ile Val Ala             105 110 115 ttt ttt gat tcc atg cgc cgc gat ctc tcc caa acc tcc tat gat ccg 499 Phe Phe Asp Ser Met Arg Arg Asp Leu Ser Gln Thr Ser Tyr Asp Pro         120 125 130 act cag ttg gat gag tac att tac ggc tcc gct gag gtc atc ggg ttg 547 Thr Gln Leu Asp Glu Tyr Ile Tyr Gly Ser Ala Glu Val Ile Gly Leu     135 140 145 atg tgt ttg aaa att ttc ctc caa gat tcc act gcc agc ccg cag gat 595 Met Cys Leu Lys Ile Phe Leu Gln Asp Ser Thr Ala Ser Pro Gln Asp 150 155 160 165 cgg gcc acg atg gaa cac ggc gcc agg cgt ttg ggt gcg gca ttt caa 643 Arg Ala Thr Met Glu His Gly Ala Arg Arg Leu Gly Ala Ala Phe Gln                 170 175 180 aag gta aat ttc ctg cga gat cta gct gaa gac cgc gaa ggc cta ggc 691 Lys Val Asn Phe Leu Arg Asp Leu Ala Glu Asp Arg Glu Gly Leu Gly             185 190 195 cgt tct tat ttg ccg gta ttc acc gaa gaa atg cgc gat gag atc gtt 739 Arg Ser Tyr Leu Pro Val Phe Thr Glu Glu Met Arg Asp Glu Ile Val         200 205 210 act gat atc cga gag gat ttg gat gcc gcc cgg ctg agc att ccg ctg 787 Thr Asp Ile Arg Glu Asp Leu Asp Ala Ala Arg Leu Ser Ile Pro Leu     215 220 225 ctg cca ttt ggc gcg cga acc ggt gtg cgc gcc gcg acc gat ctc tac 835 Leu Pro Phe Gly Ala Arg Thr Gly Val Arg Ala Ala Thr Asp Leu Tyr 230 235 240 245 ggt tgc ctc gtg gac aac ctg gaa tcc gcg tcc ctc gaa gac tta aaa 883 Gly Cys Leu Val Asp Asn Leu Glu Ser Ala Ser Leu Glu Asp Leu Lys                 250 255 260 aac ggg cgg gat ttt gtg ccg tct tta aaa aag cca gcc tgg caa cca 931 Asn Gly Arg Asp Phe Val Pro Ser Leu Lys Lys Pro Ala Trp Gln Pro             265 270 275 aag caa tgt gga aag aag tgt ttc aaa aat gac aaa agc agt ggt cat 979 Lys Gln Cys Gly Lys Lys Cys Phe Lys Asn Asp Lys Ser Ser Gly His         280 285 290 cgg cgg ggg act agc agg act agc cac cac cgc act gct ctt acg cga 1027 Arg Arg Gly Thr Ser Arg Thr Ser His His Arg Thr Ala Leu Thr Arg     295 300 305 agg ata tgaagtccac ctcgtcgaac aaa 1056 Arg Ile 310 <210> 268 <211> 311 <212> PRT <213> Corynebacterium glutamicum <400> 268 Val Ala Asp Gln Gln Asp Phe Leu Gly Arg Phe Asp Ala Met Ser Ser   1 5 10 15 Lys Ala Thr Ala Thr Val Ile Ala His Tyr Ser Ser Ser Phe Thr Leu              20 25 30 Ala Ser Lys Leu Leu Ser Pro Lys Ile Arg Arg Asp Ile Glu Ala Leu          35 40 45 Tyr Ala Met Val Arg Val Ala Asp Glu Val Val Asp Gly Ala Ala Ala      50 55 60 Ala Ala Gly Cys Ala Pro Asp Ala Val Ala Glu Ile Leu Asp Asn Tyr  65 70 75 80 Glu Arg Gln Val Leu Leu Ser Leu Ser Val Pro Phe His Thr Asp Pro                  85 90 95 Val Ile His Ala Phe Gly Asn Thr Ala Arg Lys Cys Gly Phe Glu Gln             100 105 110 Ala His Ile Val Ala Phe Phe Asp Ser Met Arg Arg Asp Leu Ser Gln         115 120 125 Thr Ser Tyr Asp Pro Thr Gln Leu Asp Glu Tyr Ile Tyr Gly Ser Ala     130 135 140 Glu Val Ile Gly Leu Met Cys Leu Lys Ile Phe Leu Gln Asp Ser Thr 145 150 155 160 Ala Ser Pro Gln Asp Arg Ala Thr Met Glu His Gly Ala Arg Arg Leu                 165 170 175 Gly Ala Ala Phe Gln Lys Val Asn Phe Leu Arg Asp Leu Ala Glu Asp             180 185 190 Arg Glu Gly Leu Gly Arg Ser Tyr Leu Pro Val Phe Thr Glu Glu Met         195 200 205 Arg Asp Glu Ile Val Thr Asp Ile Arg Glu Asp Leu Asp Ala Ala Arg     210 215 220 Leu Ser Ile Pro Leu Leu Pro Phe Gly Ala Arg Thr Gly Val Arg Ala 225 230 235 240 Ala Thr Asp Leu Tyr Gly Cys Leu Val Asp Asn Leu Glu Ser Ala Ser                 245 250 255 Leu Glu Asp Leu Lys Asn Gly Arg Asp Phe Val Pro Ser Leu Lys Lys             260 265 270 Pro Ala Trp Gln Pro Lys Gln Cys Gly Lys Lys Cys Phe Lys Asn Asp         275 280 285 Lys Ser Ser Gly His Arg Arg Gly Thr Ser Arg Thr Ser His His Arg     290 295 300 Thr Ala Leu Thr Arg Arg Ile 305 310 <210> 269 <211> 1239 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) <223> RXA00480 <400> 269 tttatggacc caaattcaca ctttctgtac ttcatcaaaa taaagcgcca tatacaacga 60 ttgggaattt ttgcgagata actggccgtg tgatactcga atg gac aat ggc atg 115                                             Met Asp Asn Gly Met                                               1 5 aca atc acc aca gaa cat tca act cat cct gat ctt gat ttc aat gat 163 Thr Ile Thr Thr Glu His Ser Thr His Pro Asp Leu Asp Phe Asn Asp                  10 15 20 gag att tat cgg gaa cta aac cgc atc tgc gct tcg cta tct caa cag 211 Glu Ile Tyr Arg Glu Leu Asn Arg Ile Cys Ala Ser Leu Ser Gln Gln              25 30 35 tgc agc aca tat caa cca gag ttc cgt acc tgc cta gat gct gct ttc 259 Cys Ser Thr Tyr Gln Pro Glu Phe Arg Thr Cys Leu Asp Ala Ala Phe          40 45 50 caa gct ttg cga ggt ggc aag tta atc cgc cct cga atg cta ctg ggg 307 Gln Ala Leu Arg Gly Gly Lys Leu Ile Arg Pro Arg Met Leu Leu Gly      55 60 65 cta tac aac acg ctt gta gac gat gac att gag gtc aaa ctc aac acc 355 Leu Tyr Asn Thr Leu Val Asp Asp Asp Ile Glu Val Lys Leu Asn Thr  70 75 80 85 gtt tta cag gta gca gtg gct tta gaa cta ctg cat ttt tcc ctt ttg 403 Val Leu Gln Val Ala Val Ala Leu Glu Leu Leu His Phe Ser Leu Leu                  90 95 100 gtt cat gac gat gtt att gac gga gac ctc tat cgc cga ggc aaa ctt 451 Val His Asp Asp Val Ile Asp Gly Asp Leu Tyr Arg Arg Gly Lys Leu             105 110 115 aat ttt att ggg cag att ctc atg cat cgc aca cct gaa agt ttt gca 499 Asn Phe Ile Gly Gln Ile Leu Met His Arg Thr Pro Glu Ser Phe Ala         120 125 130 caa atc cag cgc gat cca gag cat cta gat tgg gca caa tct aat gga 547 Gln Ile Gln Arg Asp Pro Glu His Leu Asp Trp Ala Gln Ser Asn Gly     135 140 145 ctg ctt atg gga aat ctt ttt ctt gct gcc acc cat caa atc ttc gcg 595 Leu Leu Met Gly Asn Leu Phe Leu Ala Ala Thr His Gln Ile Phe Ala 150 155 160 165 cgc ctt gac ctt cca cat cac caa cgg gtt cga ctt tta gat tta ctc 643 Arg Leu Asp Leu Pro His His Gln Arg Val Arg Leu Leu Asp Leu Leu                 170 175 180 aac cac acg ata aat gac act att gtg ggt gag ttt ctt gat gtg gga 691 Asn His Thr Ile Asn Asp Thr Ile Val Gly Glu Phe Leu Asp Val Gly             185 190 195 tta agc agc aaa gcc atc agc ccc aat atg gac att gct cta gaa atg 739 Leu Ser Ser Lys Ala Ile Ser Pro Asn Met Asp Ile Ala Leu Glu Met         200 205 210 agt cgg cta aaa aca gcc aca tac act ttt gaa ctt cca atg aga gca 787 Ser Arg Leu Lys Thr Ala Thr Tyr Thr Phe Glu Leu Pro Met Arg Ala     215 220 225 gcg gca att ctc gcg gaa cta cct cag gag att gaa aca aag ata ggt 835 Ala Ala Ile Leu Ala Glu Leu Pro Gln Glu Ile Glu Thr Lys Ile Gly 230 235 240 245 gag ata ggc aca aac ttg ggc atc gct tat caa ttg cag gac gat tac 883 Glu Ile Gly Thr Asn Leu Gly Ile Ala Tyr Gln Leu Gln Asp Asp Tyr                 250 255 260 tta tct act ttt ggt gac gca gcc gaa cac ggc aaa gat gcc ttt tct 931 Leu Ser Thr Phe Gly Asp Ala Ala Glu His Gly Lys Asp Ala Phe Ser             265 270 275 gac ctt cga gaa gga aaa gaa act aca att atc gcc ttc gct cga gat 979 Asp Leu Arg Glu Gly Lys Glu Thr Thr Ile Ile Ala Phe Ala Arg Asp         280 285 290 act gct aaa tgg act gat att caa gac aac ttc ggc tcc gca gat ctg 1027 Thr Ala Lys Trp Thr Asp Ile Gln Asp Asn Phe Gly Ser Ala Asp Leu     295 300 305 agc acc tct cag gca gag cga att caa cat ctt ctc ata cag tgt gga 1075 Ser Thr Ser Gln Ala Glu Arg Ile Gln His Leu Leu Ile Gln Cys Gly 310 315 320 325 gca aag aat cac tcc ttg aat gcc atc tcc gac cac tta aat atc tgc 1123 Ala Lys Asn His Ser Leu Asn Ala Ile Ser Asp His Leu Asn Ile Cys                 330 335 340 cgt tcg atg atc ac aaa aca cta agc ccc cag gta gat ccc aag gct caa 1171 Arg Ser Met Ile Lys Thr Leu Ser Pro Gln Val Asp Pro Lys Ala Gln             345 350 355 aat tta tta ctt aaa caa gtt gag caa cta gcc agc cgc aaa tct 1216 Asn Leu Leu Leu Lys Gln Val Glu Gln Leu Ala Ser Arg Lys Ser         360 365 370 tagaactaac ctttacgcct tta 1239 <210> 270 <211> 372 <212> PRT <213> Corynebacterium glutamicum <400> 270 Met Asp Asn Gly Met Thr Ile Thr Thr Glu His Ser Thr His Pro Asp   1 5 10 15 Leu Asp Phe Asn Asp Glu Ile Tyr Arg Glu Leu Asn Arg Ile Cys Ala              20 25 30 Ser Leu Ser Gln Gln Cys Ser Thr Tyr Gln Pro Glu Phe Arg Thr Cys          35 40 45 Leu Asp Ala Ala Phe Gln Ala Leu Arg Gly Gly Lys Leu Ile Arg Pro      50 55 60 Arg Met Leu Leu Gly Leu Tyr Asn Thr Leu Val Asp Asp Asp Ile Glu  65 70 75 80 Val Lys Leu Asn Thr Val Leu Gln Val Ala Val Ala Leu Glu Leu Leu                  85 90 95 His Phe Ser Leu Leu Val His Asp Asp Val Ile Asp Gly Asp Leu Tyr             100 105 110 Arg Arg Gly Lys Leu Asn Phe Ile Gly Gln Ile Leu Met His Arg Thr         115 120 125 Pro Glu Ser Phe Ala Gln Ile Gln Arg Asp Pro Glu His Leu Asp Trp     130 135 140 Ala Gln Ser Asn Gly Leu Leu Met Gly Asn Leu Phe Leu Ala Ala Thr 145 150 155 160 His Gln Ile Phe Ala Arg Leu Asp Leu Pro His His Gln Arg Val Arg                 165 170 175 Leu Leu Asp Leu Leu Asn His Thr Ile Asn Asp Thr Ile Val Gly Glu             180 185 190 Phe Leu Asp Val Gly Leu Ser Ser Lys Ala Ile Ser Pro Asn Met Asp         195 200 205 Ile Ala Leu Glu Met Ser Arg Leu Lys Thr Ala Thr Tyr Thr Phe Glu     210 215 220 Leu Pro Met Arg Ala Ala Ala Ile Leu Ala Glu Leu Pro Gln Glu Ile 225 230 235 240 Glu Thr Lys Ile Gly Glu Ile Gly Thr Asn Leu Gly Ile Ala Tyr Gln                 245 250 255 Leu Gln Asp Asp Tyr Leu Ser Thr Phe Gly Asp Ala Ala Glu His Gly             260 265 270 Lys Asp Ala Phe Ser Asp Leu Arg Glu Gly Lys Glu Thr Thr Ile Ile         275 280 285 Ala Phe Ala Arg Asp Thr Ala Lys Trp Thr Asp Ile Gln Asp Asn Phe     290 295 300 Gly Ser Ala Asp Leu Ser Thr Ser Gln Ala Glu Arg Ile Gln His Leu 305 310 315 320 Leu Ile Gln Cys Gly Ala Lys Asn His Ser Leu Asn Ala Ile Ser Asp                 325 330 335 His Leu Asn Ile Cys Arg Ser Met Ile Lys Thr Leu Ser Pro Gln Val             340 345 350 Asp Pro Lys Ala Gln Asn Leu Leu Leu Lys Gln Val Glu Gln Leu Ala         355 360 365 Ser Arg Lys Ser     370 <210> 271 <211> 1056 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1033) <223> RXS01879 <400> 271 ctttgcgggc cgctgatatt gatccaacgc ttcgtggcga aaagcttgat gtcactgact 60 atgtgcgcct agctggggtg ttgcagcaaa aggatgagaa gtg aaa att acc gct 115                                             Val Lys Ile Thr Ala                                               1 5 aag gcg tgg gcg aaa acc aac ctg cat tta ggt gtg gga ccg gct cac 163 Lys Ala Trp Ala Lys Thr Asn Leu His Leu Gly Val Gly Pro Ala His                  10 15 20 gac gat gga ttt cac gag ctc atg acg gtg ttt caa acc att gat ctg 211 Asp Asp Gly Phe His Glu Leu Met Thr Val Phe Gln Thr Ile Asp Leu              25 30 35 ttt gac acc gtc acc tta acc acc ctc gat gag gag ttg gtg gag gag 259 Phe Asp Thr Val Thr Leu Thr Thr Leu Asp Glu Glu Leu Val Glu Glu          40 45 50 ggg agc gtc gtc aag caa tta tct gtg acc ggt gcc cgt ggc gtg cct 307 Gly Ser Val Val Lys Gln Leu Ser Val Thr Gly Ala Arg Gly Val Pro      55 60 65 gag gac gcc agc aat ctt gcg tgg cgc gct gtg gat gcg ttg gtt aag 355 Glu Asp Ala Ser Asn Leu Ala Trp Arg Ala Val Asp Ala Leu Val Lys  70 75 80 85 cgg cgc gcg gaa aag acg ccg ctg tct gca gtt tcg ctg cat att tcc 403 Arg Arg Ala Glu Lys Thr Pro Leu Ser Ala Val Ser Leu His Ile Ser                  90 95 100 aag ggg att ccg gtg gct ggc ggc atg gct ggc ggc tct gcg gat gcg 451 Lys Gly Ile Pro Val Ala Gly Gly Met Ala Gly Gly Ser Ala Asp Ala             105 110 115 gct gcg aca ctg cgc gca gtg gat gcc tgg att ggg cct ttc ggc gag 499 Ala Ala Thr Leu Arg Ala Val Asp Ala Trp Ile Gly Pro Phe Gly Glu         120 125 130 gac aca ttg ctg gag gtt gcc gcg gag ctc ggc tca gat gtg ccg ttt 547 Asp Thr Leu Leu Glu Val Ala Ala Glu Leu Gly Ser Asp Val Pro Phe     135 140 145 tgc ctg ctt ggt ggc acc atg cgc ggt acc ggt cgc ggc gag cag ctg 595 Cys Leu Leu Gly Gly Thr Met Arg Gly Thr Gly Arg Gly Glu Gln Leu 150 155 160 165 gta gat atg ttg acg cgc ggc aag cta cat tgg gtg gtg gcc gcg atg 643 Val Asp Met Leu Thr Arg Gly Lys Leu His Trp Val Val Ala Ala Met                 170 175 180 gcg cat ggc ctg tcc acg cct gag gta ttc aaa aag cat gat gag ctg 691 Ala His Gly Leu Ser Thr Pro Glu Val Phe Lys Lys His Asp Glu Leu             185 190 195 aat ccg gaa tcg cat atg gat atc agc gac ctc agc gcc gca ctt ctc 739 Asn Pro Glu Ser His Met Asp Ile Ser Asp Leu Ser Ala Ala Leu Leu         200 205 210 acc ggc aac acc gcc gag gtg ggg cag tgg ctg cac aat gat ctg acc 787 Thr Gly Asn Thr Ala Glu Val Gly Gln Trp Leu His Asn Asp Leu Thr     215 220 225 agc gcc gca ctc agt ttg cgc cct gaa ctg cgc agc gtc ctc caa gaa 835 Ser Ala Ala Leu Ser Leu Arg Pro Glu Leu Arg Ser Val Leu Gln Glu 230 235 240 245 ggc atc cgc tcc ggc gcg cat gca gga att gtc tcc ggc tcc ggc ccg 883 Gly Ile Arg Ser Gly Ala His Ala Gly Ile Val Ser Gly Ser Gly Pro                 250 255 260 acc acg gta ttc ttg tgc gaa tcg gag cac aaa gcg caa gac gtt aaa 931 Thr Thr Val Phe Leu Cys Glu Ser Glu His Lys Ala Gln Asp Val Lys             265 270 275 gag gcg cta atc gac gcc ggc cag gtg tac gct gct tac acc gcc acc 979 Glu Ala Leu Ile Asp Ala Gly Gln Val Tyr Ala Ala Tyr Thr Ala Thr         280 285 290 ggc cct gcg gcc tca acc gcc gac cag cgc ggc gca cac att ttg act 1027 Gly Pro Ala Ala Ser Thr Ala Asp Gln Arg Gly Ala His Ile Leu Thr     295 300 305 gtt tca taataaagac aaacttaagt atc 1056 Val Ser 310 <210> 272 <211> 311 <212> PRT <213> Corynebacterium glutamicum <400> 272 Val Lys Ile Thr Ala Lys Ala Trp Ala Lys Thr Asn Leu His Leu Gly   1 5 10 15 Val Gly Pro Ala His Asp Asp Gly Phe His Glu Leu Met Thr Val Phe              20 25 30 Gln Thr Ile Asp Leu Phe Asp Thr Val Thr Leu Thr Thr Leu Asp Glu          35 40 45 Glu Leu Val Glu Glu Gly Ser Val Val Lys Gln Leu Ser Val Thr Gly      50 55 60 Ala Arg Gly Val Pro Glu Asp Ala Ser Asn Leu Ala Trp Arg Ala Val  65 70 75 80 Asp Ala Leu Val Lys Arg Arg Ala Glu Lys Thr Pro Leu Ser Ala Val                  85 90 95 Ser Leu His Ile Ser Lys Gly Ile Pro Val Ala Gly Gly Met Ala Gly             100 105 110 Gly Ser Ala Asp Ala Ala Ala Thr Leu Arg Ala Val Asp Ala Trp Ile         115 120 125 Gly Pro Phe Gly Glu Asp Thr Leu Leu Glu Val Ala Ala Glu Leu Gly     130 135 140 Ser Asp Val Pro Phe Cys Leu Leu Gly Gly Thr Met Arg Gly Thr Gly 145 150 155 160 Arg Gly Glu Gln Leu Val Asp Met Leu Thr Arg Gly Lys Leu His Trp                 165 170 175 Val Val Ala Ala Met Ala His Gly Leu Ser Thr Pro Glu Val Phe Lys             180 185 190 Lys His Asp Glu Leu Asn Pro Glu Ser His Met Asp Ile Ser Asp Leu         195 200 205 Ser Ala Ala Leu Leu Thr Gly Asn Thr Ala Glu Val Gly Gln Trp Leu     210 215 220 His Asn Asp Leu Thr Ser Ala Ala Leu Ser Leu Arg Pro Glu Leu Arg 225 230 235 240 Ser Val Leu Gln Glu Gly Ile Arg Ser Gly Ala His Ala Gly Ile Val                 245 250 255 Ser Gly Ser Gly Pro Thr Thr Val Phe Leu Cys Glu Ser Glu His Lys             260 265 270 Ala Gln Asp Val Lys Glu Ala Leu Ile Asp Ala Gly Gln Val Tyr Ala         275 280 285 Ala Tyr Thr Ala Thr Gly Pro Ala Ala Ser Thr Ala Asp Gln Arg Gly     290 295 300 Ala His Ile Leu Thr Val Ser 305 310 <210> 273 <211> 891 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (868) <223> RXS02023 <400> 273 gatgtggcag caattttgaa gcagtacctg agcgagtaac cgcattcggg gttatcgtgg 60 gacttccgaa atgtaactag agactagagg aggaaacacg atg gct cct aaa caa 115                                             Met Ala Pro Lys Gln                                               1 5 act ccc agc cca gag aag aat cga aac ctg gtg gga cca gtt ctg caa 163 Thr Pro Ser Pro Glu Lys Asn Arg Asn Leu Val Gly Pro Val Leu Gln                  10 15 20 cgt cgg cag aca gag ggt act ttt gat caa cgc ttg cta gaa atg cgc 211 Arg Arg Gln Thr Glu Gly Thr Phe Asp Gln Arg Leu Leu Glu Met Arg              25 30 35 gct gat cac aat tgg aag cac gcc gat cca tgg cgt gta ctg cgt att 259 Ala Asp His Asn Trp Lys His Ala Asp Pro Trp Arg Val Leu Arg Ile          40 45 50 cag tct gag ttt gtg gcg ggt ttt gat gcc ctc cac gag atg cca aag 307 Gln Ser Glu Phe Val Ala Gly Phe Asp Ala Leu His Glu Met Pro Lys      55 60 65 gcc gta acc gtc ttt ggt tcc gca cgc att aaa gag gat cac ccg tac 355 Ala Val Thr Val Phe Gly Ser Ala Arg Ile Lys Glu Asp His Pro Tyr  70 75 80 85 tac aag gcg ggt gta gaa ctt ggt gaa aag ctc gtt gca gcg gac tac 403 Tyr Lys Ala Gly Val Glu Leu Gly Glu Lys Leu Val Ala Ala Asp Tyr                  90 95 100 gca gtt gtc acc ggt ggc ggt cca ggt ctg atg gaa gcc ccc aat aag 451 Ala Val Val Thr Gly Gly Gly Pro Gly Leu Met Glu Ala Pro Asn Lys             105 110 115 ggg gca agc gag gcc aat ggt tta tca gtt ggt ctg ggc att gag ttg 499 Gly Ala Ser Glu Ala Asn Gly Leu Ser Val Gly Leu Gly Ile Glu Leu         120 125 130 cca cat gaa cag cat ctg aac cct tat gtg gat ttg ggt ctg aac ttc 547 Pro His Glu Gln His Leu Asn Pro Tyr Val Asp Leu Gly Leu Asn Phe     135 140 145 cgg tac ttc ttc gca cgc aag acc atg ttc ctg aaa tac tcc cag gct 595 Arg Tyr Phe Phe Ala Arg Lys Thr Met Phe Leu Lys Tyr Ser Gln Ala 150 155 160 165 ttt gtg tgt ctg cct ggt ggt ttc ggc acg ctc gat gag ctt ttc gag 643 Phe Val Cys Leu Pro Gly Gly Phe Gly Thr Leu Asp Glu Leu Phe Glu                 170 175 180 gtc ctc tgc atg gta caa acc ggc aag gta ccc aac ttt ccc atc gtg 691 Val Leu Cys Met Val Gln Thr Gly Lys Val Pro Asn Phe Pro Ile Val             185 190 195 ctg atc ggc act gag ttc tgg gca ggt ttg gtg gat tgg atc cgt cac 739 Leu Ile Gly Thr Glu Phe Trp Ala Gly Leu Val Asp Trp Ile Arg His         200 205 210 cgc ctg gta gag gaa ggc atg atc gat gag aag gat gtt gac cgg atg 787 Arg Leu Val Glu Glu Gly Met Ile Asp Glu Lys Asp Val Asp Arg Met     215 220 225 ttg gtc act gat gac ctg gat cag gcc gtc aaa ttc atc gtc gat gca 835 Leu Val Thr Asp Asp Leu Asp Gln Ala Val Lys Phe Ile Val Asp Ala 230 235 240 245 cac gct gga ttg gac gta gcg cgt ctc cac aat taagcagtgg ctacattagg 888 His Ala Gly Leu Asp Val Ala Arg Leu His Asn                 250 255 tgt 891 <210> 274 <211> 256 <212> PRT <213> Corynebacterium glutamicum <400> 274 Met Ala Pro Lys Gln Thr Pro Ser Pro Glu Lys Asn Arg Asn Leu Val   1 5 10 15 Gly Pro Val Leu Gln Arg Arg Gln Thr Glu Gly Thr Phe Asp Gln Arg              20 25 30 Leu Leu Glu Met Arg Ala Asp His Asn Trp Lys His Ala Asp Pro Trp          35 40 45 Arg Val Leu Arg Ile Gln Ser Glu Phe Val Ala Gly Phe Asp Ala Leu      50 55 60 His Glu Met Pro Lys Ala Val Thr Val Phe Gly Ser Ala Arg Ile Lys  65 70 75 80 Glu Asp His Pro Tyr Tyr Lys Ala Gly Val Glu Leu Gly Glu Lys Leu                  85 90 95 Val Ala Ala Asp Tyr Ala Val Val Thr Gly Gly Gly Pro Gly Leu Met             100 105 110 Glu Ala Pro Asn Lys Gly Ala Ser Glu Ala Asn Gly Leu Ser Val Gly         115 120 125 Leu Gly Ile Glu Leu Pro His Glu Gln His Leu Asn Pro Tyr Val Asp     130 135 140 Leu Gly Leu Asn Phe Arg Tyr Phe Phe Ala Arg Lys Thr Met Phe Leu 145 150 155 160 Lys Tyr Ser Gln Ala Phe Val Cys Leu Pro Gly Gly Phe Gly Thr Leu                 165 170 175 Asp Glu Leu Phe Glu Val Leu Cys Met Val Gln Thr Gly Lys Val Pro             180 185 190 Asn Phe Pro Ile Val Leu Ile Gly Thr Glu Phe Trp Ala Gly Leu Val         195 200 205 Asp Trp Ile Arg His Arg Leu Val Glu Glu Gly Met Ile Asp Glu Lys     210 215 220 Asp Val Asp Arg Met Leu Val Thr Asp Asp Leu Asp Gln Ala Val Lys 225 230 235 240 Phe Ile Val Asp Ala His Ala Gly Leu Asp Val Ala Arg Leu His Asn                 245 250 255 <210> 275 <211> 1242 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1219) <223> RXS00948 <400> 275 acaccctcca aatgatctcg taaaacagta ttgaatttag gtacgactct aatcgtacct 60 tgccctcaag ccaagctagt tgtacgatca aactcgttgt atg gca aac gtc gta 115                                             Met ala asn val val                                               1 5 cta gtc gat cga atg gag cct ttg gtg tcc aag ctg ttt acc cca att 163 Leu Val Asp Arg Met Glu Pro Leu Val Ser Lys Leu Phe Thr Pro Ile                  10 15 20 caa atc cgc gac atc acc atc ccc aac cgc gtg tgg atg tca ccg atg 211 Gln Ile Arg Asp Ile Thr Ile Pro Asn Arg Val Trp Met Ser Pro Met              25 30 35 tgc acc tac tct gca gcc acc ggt tca ggt ctt ccc acc gat ttt cac 259 Cys Thr Tyr Ser Ala Ala Thr Gly Ser Gly Leu Pro Thr Asp Phe His          40 45 50 cag gct cat tac gca gct cgc gca gca ggt ggt gtc gga tta gtc atg 307 Gln Ala His Tyr Ala Ala Arg Ala Ala Gly Gly Val Gly Leu Val Met      55 60 65 gtt gaa gca act gga gtg aac ccc gta gct ccc atc tcc cca gtc gac 355 Val Glu Ala Thr Gly Val Asn Pro Val Ala Pro Ile Ser Pro Val Asp  70 75 80 85 ctt gga ctt tgg agc cat gac caa att gaa cca ttc tcc cga gtg aca 403 Leu Gly Leu Trp Ser His Asp Gln Ile Glu Pro Phe Ser Arg Val Thr                  90 95 100 gca gct att cgc gcc ggt ggg gca gta ccg gcc gtt caa tta gcc cat 451 Ala Ala Ile Arg Ala Gly Gly Ala Val Pro Ala Val Gln Leu Ala His             105 110 115 gct ggc cgc aag gca tcc acc gat gct ccg tgg aat ggt ggc gga tat 499 Ala Gly Arg Lys Ala Ser Thr Asp Ala Pro Trp Asn Gly Gly Gly Tyr         120 125 130 gtt gga cca gaa acc aat gga tgg gag act gtc ggc ccc agc cct ctg 547 Val Gly Pro Glu Thr Asn Gly Trp Glu Thr Val Gly Pro Ser Pro Leu     135 140 145 gca ttc cca ggt ttg cct gct ccg cgc gag ctg acg gtt tca gaa atc 595 Ala Phe Pro Gly Leu Pro Ala Pro Arg Glu Leu Thr Val Ser Glu Ile 150 155 160 165 caa gag gtt gtg cag cag ttc gct ggc gcc gcc gtt cgt gcc gat cag 643 Gln Glu Val Val Gln Gln Phe Ala Gly Ala Ala Val Arg Ala Asp Gln                 170 175 180 gct ggt ttt gat gtc gtg gaa att cac gca gca cac ggc tac ctt ttg 691 Ala Gly Phe Asp Val Val Glu Ile His Ala Ala His Gly Tyr Leu Leu             185 190 195 cat aac ttc ctt tct ccg atc tcc aac aag cgc acc gat tca tac ggc 739 His Asn Phe Leu Ser Pro Ile Ser Asn Lys Arg Thr Asp Ser Tyr Gly         200 205 210 gga tct tta gaa aac cgc gct cgc atc gtg ctc gaa gtc att gat gca 787 Gly Ser Leu Glu Asn Arg Ala Arg Ile Val Leu Glu Val Ile Asp Ala     215 220 225 atc cgc gca gtg tgg cca gag gaa aag cct gta ttc atg cgc att tcc 835 Ile Arg Ala Val Trp Pro Glu Glu Lys Pro Val Phe Met Arg Ile Ser 230 235 240 245 acc acc gac tgg gtg gag gaa aac cca cag gat gat cgc gag tcc tgg 883 Thr Thr Asp Trp Val Glu Glu Asn Pro Gln Asp Asp Arg Glu Ser Trp                 250 255 260 acg ctg agc caa agc agg cag ctg gct ttg tgg gca tcc gag cac gga 931 Thr Leu Ser Gln Ser Arg Gln Leu Ala Leu Trp Ala Ser Glu His Gly             265 270 275 gtt gat ttg atc gat gcc tct tct ggt ggc ctc gac atc gtc ccc att 979 Val Asp Leu Ile Asp Ala Ser Ser Gly Gly Leu Asp Ile Val Pro Ile         280 285 290 ccg cat gac cgc gat tac caa acc gcg aag gcc gca gat ctt cac gca 1027 Pro His Asp Arg Asp Tyr Gln Thr Ala Lys Ala Ala Asp Leu His Ala     295 300 305 agt acc gga gtg aca gtc gct gct gtg ggg cgc att gat gac gcc caa 1075 Ser Thr Gly Val Thr Val Ala Ala Val Gly Arg Ile Asp Asp Ala Gln 310 315 320 325 act gcg cac aat ttg gtt gat tct ggc gat gtc aat gca gtt ttc ctc 1123 Thr Ala His Asn Leu Val Asp Ser Gly Asp Val Asn Ala Val Phe Leu                 330 335 340 ggc cgt cca ctg ctc aag gat cct tcc tgg gca aac caa gca gcc ctc 1171 Gly Arg Pro Leu Leu Lys Asp Pro Ser Trp Ala Asn Gln Ala Ala Leu             345 350 355 gca cta ggt gcg gaa ccc agg tat gtt cac caa tac gac tac gta ctt 1219 Ala Leu Gly Ala Glu Pro Arg Tyr Val His Gln Tyr Asp Tyr Val Leu         360 365 370 taaaggagag ttgacatgaa ggt 1242 <210> 276 <211> 373 <212> PRT <213> Corynebacterium glutamicum <400> 276 Met Ala Asn Val Val Leu Val Asp Arg Met Glu Pro Leu Val Ser Lys   1 5 10 15 Leu Phe Thr Pro Ile Gln Ile Arg Asp Ile Thr Ile Pro Asn Arg Val              20 25 30 Trp Met Ser Pro Met Cys Thr Tyr Ser Ala Ala Thr Gly Ser Gly Leu          35 40 45 Pro Thr Asp Phe His Gln Ala His Tyr Ala Ala Arg Ala Ala Gly Gly      50 55 60 Val Gly Leu Val Met Val Glu Ala Thr Gly Val Asn Pro Val Ala Pro  65 70 75 80 Ile Ser Pro Val Asp Leu Gly Leu Trp Ser His Asp Gln Ile Glu Pro                  85 90 95 Phe Ser Arg Val Thr Ala Ala Ile Arg Ala Gly Gly Ala Val Pro Ala             100 105 110 Val Gln Leu Ala His Ala Gly Arg Lys Ala Ser Thr Asp Ala Pro Trp         115 120 125 Asn Gly Gly Gly Tyr Val Gly Pro Glu Thr Asn Gly Trp Glu Thr Val     130 135 140 Gly Pro Ser Pro Leu Ala Phe Pro Gly Leu Pro Ala Pro Arg Glu Leu 145 150 155 160 Thr Val Ser Glu Ile Gln Glu Val Val Gln Gln Phe Ala Gly Ala Ala                 165 170 175 Val Arg Ala Asp Gln Ala Gly Phe Asp Val Val Glu Ile His Ala Ala             180 185 190 His Gly Tyr Leu Leu His Asn Phe Leu Ser Pro Ile Ser Asn Lys Arg         195 200 205 Thr Asp Ser Tyr Gly Gly Ser Leu Glu Asn Arg Ala Arg Ile Val Leu     210 215 220 Glu Val Ile Asp Ala Ile Arg Ala Val Trp Pro Glu Glu Lys Pro Val 225 230 235 240 Phe Met Arg Ile Ser Thr Thr Asp Trp Val Glu Glu Asn Pro Gln Asp                 245 250 255 Asp Arg Glu Ser Trp Thr Leu Ser Gln Ser Arg Gln Leu Ala Leu Trp             260 265 270 Ala Ser Glu His Gly Val Asp Leu Ile Asp Ala Ser Ser Gly Gly Leu         275 280 285 Asp Ile Val Pro Ile Pro His Asp Arg Asp Tyr Gln Thr Ala Lys Ala     290 295 300 Ala Asp Leu His Ala Ser Thr Gly Val Thr Val Ala Ala Val Gly Arg 305 310 315 320 Ile Asp Asp Ala Gln Thr Ala His Asn Leu Val Asp Ser Gly Asp Val                 325 330 335 Asn Ala Val Phe Leu Gly Arg Pro Leu Leu Lys Asp Pro Ser Trp Ala             340 345 350 Asn Gln Ala Ala Leu Ala Leu Gly Ala Glu Pro Arg Tyr Val His Gln         355 360 365 Tyr Asp Tyr Val Leu     370 <210> 277 <211> 1026 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <101> (101) .. (1003) <223> RXS02228 <400> 277 acagaagcgt caactgctca acttctcgac agcgacgaca cacacggcgt gggacgctac 60 gttgctcgct ggacttttta acttaaggga gatctagatc gtg gta aca ccg atc 115                                             Val Val Thr Pro Ile                                               1 5 gca gtg gtt gga ccc act gca tct gga aaa tca gct ttg gga att gct 163 Ala Val Val Gly Pro Thr Ala Ser Gly Lys Ser Ala Leu Gly Ile Ala                  10 15 20 cta gcc cac aag ctt gac ggt gaa gta gtc aat gtg gat tcc atg cag 211 Leu Ala His Lys Leu Asp Gly Glu Val Val Asn Val Asp Ser Met Gln              25 30 35 ctg tac aaa ggc atg gac atc ggc acg gca aag ctg act gtc gaa gaa 259 Leu Tyr Lys Gly Met Asp Ile Gly Thr Ala Lys Leu Thr Val Glu Glu          40 45 50 cgc gaa ggc att gcg cat cat cag ctc gat gtc tgg gac gtt acc gaa 307 Arg Glu Gly Ile Ala His His Gln Leu Asp Val Trp Asp Val Thr Glu      55 60 65 act gcg tca gtg gcg agg ttt caa tcc gac gcc gtt gcc gat gtg gaa 355 Thr Ala Ser Val Ala Arg Phe Gln Ser Asp Ala Val Ala Asp Val Glu  70 75 80 85 gat att atg tcc cgt ggc aaa acc ccc atc ttg gtt ggc ggc tcc atg 403 Asp Ile Met Ser Arg Gly Lys Thr Pro Ile Leu Val Gly Gly Ser Met                  90 95 100 ttg tac gtc caa tct ttg gtc gat gat tgg caa ttc cca cct acc gac 451 Leu Tyr Val Gln Ser Leu Val Asp Asp Trp Gln Phe Pro Pro Thr Asp             105 110 115 agc gct gtt cgc gca cgc ttt gag gcc cgc ttg gca gac atc ggt gtc 499 Ser Ala Val Arg Ala Arg Phe Glu Ala Arg Leu Ala Asp Ile Gly Val         120 125 130 gaa gca cta cac gct gaa ctt act cag ctt gac cca gaa gca gca gcc 547 Glu Ala Leu His Ala Glu Leu Thr Gln Leu Asp Pro Glu Ala Ala Ala     135 140 145 gtc atc gaa agc aat gat ccc cga cgc acc gtc cga gca tta gaa gtc 595 Val Ile Glu Ser Asn Asp Pro Arg Arg Thr Val Arg Ala Leu Glu Val 150 155 160 165 att gaa cta acc ggc cag ccc ttc caa gca agc caa ccg ccc aaa gac 643 Ile Glu Leu Thr Gly Gln Pro Phe Gln Ala Ser Gln Pro Pro Lys Asp                 170 175 180 gcg cca cct cgc tgg gga act cga atc att ggc ctg aaa acc act cca 691 Ala Pro Pro Arg Trp Gly Thr Arg Ile Ily Gly Leu Lys Thr Thr Pro             185 190 195 gaa tgg cta aat cca cgc atc gag cag cgc acc gcc agg atg ttt gaa 739 Glu Trp Leu Asn Pro Arg Ile Glu Gln Arg Thr Ala Arg Met Phe Glu         200 205 210 caa ggc ttt gtc gcc gaa gtg gaa cac ctt gtg cag caa gga ctc atc 787 Gln Gly Phe Val Ala Glu Val Glu His Leu Val Gln Gln Gly Leu Ile     215 220 225 gct gac tcc acc gcg gga cga gca atc ggc tac tcc caa gta ctg gca 835 Ala Asp Ser Thr Ala Gly Arg Ala Ile Gly Tyr Ser Gln Val Leu Ala 230 235 240 245 gcc atg gca ggg gag atg acc tgg gaa gac gcc ttc gaa cgc acg gtc 883 Ala Met Ala Gly Glu Met Thr Trp Glu Asp Ala Phe Glu Arg Thr Val                 250 255 260 acc gga acc aga cgc tat gtc agg cgc caa cgc agc tgg ttc aac aga 931 Thr Gly Thr Arg Arg Tyr Val Arg Arg Gln Arg Ser Trp Phe Asn Arg             265 270 275 gac cac cgc gtg tcc tgg gtc gac gcc tct ggc gat ccc acc gca caa 979 Asp His Arg Val Ser Trp Val Asp Ala Ser Gly Asp Pro Thr Ala Gln         280 285 290 gcc ttg gag att ttg ggt cta caa tagcgagggt gaatttgacc atc 1026 Ala Leu Glu Ile Leu Gly Leu Gln     295 300 <210> 278 <211> 301 <212> PRT <213> Corynebacterium glutamicum <400> 278 Val Val Thr Pro Ile Ala Val Val Gly Pro Thr Ala Ser Gly Lys Ser   1 5 10 15 Ala Leu Gly Ile Ala Leu Ala His Lys Leu Asp Gly Glu Val Val Asn              20 25 30 Val Asp Ser Met Gln Leu Tyr Lys Gly Met Asp Ile Gly Thr Ala Lys          35 40 45 Leu Thr Val Glu Glu Arg Glu Gly Ile Ala His His Gln Leu Asp Val      50 55 60 Trp Asp Val Thr Glu Thr Ala Ser Val Ala Arg Phe Gln Ser Asp Ala  65 70 75 80 Val Ala Asp Val Glu Asp Ile Met Ser Arg Gly Lys Thr Pro Ile Leu                  85 90 95 Val Gly Gly Ser Met Leu Tyr Val Gln Ser Leu Val Asp Asp Trp Gln             100 105 110 Phe Pro Pro Thr Asp Ser Ala Val Arg Ala Arg Phe Glu Ala Arg Leu         115 120 125 Ala Asp Ile Gly Val Glu Ala Leu His Ala Glu Leu Thr Gln Leu Asp     130 135 140 Pro Glu Ala Ala Ala Val Ile Glu Ser Asn Asp Pro Arg Arg Thr Val 145 150 155 160 Arg Ala Leu Glu Val Ile Glu Leu Thr Gly Gln Pro Phe Gln Ala Ser                 165 170 175 Gln Pro Pro Lys Asp Ala Pro Pro Arg Trp Gly Thr Arg Ile Ily Gly             180 185 190 Leu Lys Thr Thr Pro Glu Trp Leu Asn Pro Arg Ile Glu Gln Arg Thr         195 200 205 Ala Arg Met Phe Glu Gln Gly Phe Val Ala Glu Val Glu His Leu Val     210 215 220 Gln Gln Gly Leu Ile Ala Asp Ser Thr Ala Gly Arg Ala Ile Gly Tyr 225 230 235 240 Ser Gln Val Leu Ala Ala Met Ala Gly Glu Met Thr Trp Glu Asp Ala                 245 250 255 Phe Glu Arg Thr Val Thr Gly Thr Arg Arg Tyr Val Arg Arg Gln Arg             260 265 270 Ser Trp Phe Asn Arg Asp His Arg Val Ser Trp Val Asp Ala Ser Gly         275 280 285 Asp Pro Thr Ala Gln Ala Leu Glu Ile Leu Gly Leu Gln     290 295 300 <210> 279 <211> 954 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (931) <223> RXC01971 <400> 279 aggtcttgtt tatttcggct actgattcag tagctgcgct ccgataggat tcttagtttt 60 cagttcagta tctttgagcc acggctagaa tgtgaatcct atg tct aag aag aag 115                                             Met Ser Lys Lys Lys                                               1 5 cct cgc ccc att ccg gtt cct gcc caa ttt atc cct ggt ctc att gat 163 Pro Arg Pro Ile Pro Val Pro Ala Gln Phe Ile Pro Gly Leu Ile Asp                  10 15 20 gcg cat aca cat ttg gca tcg tgt gga gga gat ctt gca ggg ttg gtg 211 Ala His Thr His Leu Ala Ser Cys Gly Gly Asp Leu Ala Gly Leu Val              25 30 35 gaa agg gcc aag gag gcg ggc gtc gaa aag ctt tgt acc gtc ggt gat 259 Glu Arg Ala Lys Glu Ala Gly Val Glu Lys Leu Cys Thr Val Gly Asp          40 45 50 ggt ttg gct gag gcc gag ctt gcg ctg gag gcc gcg caa cag ttt ggc 307 Gly Leu Ala Glu Ala Glu Leu Ala Leu Glu Ala Ala Gln Gln Phe Gly      55 60 65 aat gtg ttt gct gcg tgt gcg att cat ccg acg aag gct gat cag ttg 355 Asn Val Phe Ala Ala Cys Ala Ile His Pro Thr Lys Ala Asp Gln Leu  70 75 80 85 gat ggg gct gcg cgt gcg cgg ctg acg cag atg gcg gcg gat ccg aat 403 Asp Gly Ala Ala Arg Ala Arg Leu Thr Gln Met Ala Ala Asp Pro Asn                  90 95 100 tgt gtg gcc att ggt gag act ggt ttg gat tcg tat tgg atc aag cac 451 Cys Val Ala Ile Gly Glu Thr Gly Leu Asp Ser Tyr Trp Ile Lys His             105 110 115 gat cca gag gac acg gcg gcg ttg gat gtg caa gag gag gcg ctg cgc 499 Asp Pro Glu Asp Thr Ala Ala Leu Asp Val Gln Glu Glu Ala Leu Arg         120 125 130 tgg cat att gat ttg gca att agt gcg gat aag ccg ttg atg att cac 547 Trp His Ile Asp Leu Ala Ile Ser Ala Asp Lys Pro Leu Met Ile His     135 140 145 aat cgt gag gcg gat gct gat ttg atg cga gtg ttg gcg gat gct cca 595 Asn Arg Glu Ala Asp Ala Asp Leu Met Arg Val Leu Ala Asp Ala Pro 150 155 160 165 cct cca aaa gat acg att ctg cat tgt ttt tct tcg ccg ttg gac gtg 643 Pro Pro Lys Asp Thr Ile Leu His Cys Phe Ser Ser Pro Leu Asp Val                 170 175 180 gcg aag gaa gcg ttg gat cgt gga tat gtg ttg agt ttt gcg ggc aat 691 Ala Lys Glu Ala Leu Asp Arg Gly Tyr Val Leu Ser Phe Ala Gly Asn             185 190 195 gtg acg ttt aag cgt aat gag gag ttg cgg gag gct gct cgt att gcg 739 Val Thr Phe Lys Arg Asn Glu Glu Leu Arg Glu Ala Ala Arg Ile Ala         200 205 210 ccg att tcc cag att ttg att gaa acc gat gcg ccg tat atg acg ccg 787 Pro Ile Ser Gln Ile Leu Ile Glu Thr Asp Ala Pro Tyr Met Thr Pro     215 220 225 gag ccg ttt cgg ggg agt agg aat gag ccg tcg ttg att ggt cat acg 835 Glu Pro Phe Arg Gly Ser Arg Asn Glu Pro Ser Leu Ile Gly His Thr 230 235 240 245 gcg cta tgc att gcg gag gtt cgg ggg atg gct gtg gag gat gtt gcg 883 Ala Leu Cys Ile Ala Glu Val Arg Gly Met Ala Val Glu Asp Val Ala                 250 255 260 gcg gct ttg aat gag aat ttt gat cgc gtt tat ggg gtc aca aat cta 931 Ala Ala Leu Asn Glu Asn Phe Asp Arg Val Tyr Gly Val Thr Asn Leu             265 270 275 taacgtgagg tagctcacag tca 954 <210> 280 <211> 277 <212> PRT <213> Corynebacterium glutamicum <400> 280 Met Ser Lys Lys Lys Pro Arg Pro Ile Pro Val Pro Ala Gln Phe Ile   1 5 10 15 Pro Gly Leu Ile Asp Ala His Thr His Leu Ala Ser Cys Gly Gly Asp              20 25 30 Leu Ala Gly Leu Val Glu Arg Ala Lys Glu Ala Gly Val Glu Lys Leu          35 40 45 Cys Thr Val Gly Asp Gly Leu Ala Glu Ala Glu Leu Ala Leu Glu Ala      50 55 60 Ala Gln Gln Phe Gly Asn Val Phe Ala Ala Cys Ala Ile His Pro Thr  65 70 75 80 Lys Ala Asp Gln Leu Asp Gly Ala Ala Arg Ala Arg Leu Thr Gln Met                  85 90 95 Ala Ala Asp Pro Asn Cys Val Ala Ile Gly Glu Thr Gly Leu Asp Ser             100 105 110 Tyr Trp Ile Lys His Asp Pro Glu Asp Thr Ala Ala Leu Asp Val Gln         115 120 125 Glu Glu Ala Leu Arg Trp His Ile Asp Leu Ala Ile Ser Ala Asp Lys     130 135 140 Pro Leu Met Ile His Asn Arg Glu Ala Asp Ala Asp Leu Met Arg Val 145 150 155 160 Leu Ala Asp Ala Pro Pro Pro Lys Asp Thr Ile Leu His Cys Phe Ser                 165 170 175 Ser Pro Leu Asp Val Ala Lys Glu Ala Leu Asp Arg Gly Tyr Val Leu             180 185 190 Ser Phe Ala Gly Asn Val Thr Phe Lys Arg Asn Glu Glu Leu Arg Glu         195 200 205 Ala Ala Arg Ile Ala Pro Ile Ser Gln Ile Leu Ile Glu Thr Asp Ala     210 215 220 Pro Tyr Met Thr Pro Glu Pro Phe Arg Gly Ser Arg Asn Glu Pro Ser 225 230 235 240 Leu Ile Gly His Thr Ala Leu Cys Ile Ala Glu Val Arg Gly Met Ala                 245 250 255 Val Glu Asp Val Ala Ala Ala Leu Asn Glu Asn Phe Asp Arg Val Tyr             260 265 270 Gly Val Thr Asn Leu         275 <210> 281 <211> 1650 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1627) <223> RXC02697 <400> 281 tttggctcac ctcgatgatg tagacatccc cgatgaggtg cgcgcacagt tgcgggcact 60 ggctatccgc tcaaccgaac gtcggatgta gtagacgcgt atg aca ctt ttt caa 115                                             Met thr leu phe gln                                               1 5 cgt tta acc aac cct gta gtg ctc ggc ggc cta gca ggt gtt ttg ctt 163 Arg Leu Thr Asn Pro Val Val Leu Gly Gly Leu Ala Gly Val Leu Leu                  10 15 20 ctg ctc ggc tct ttc ggt ggc ggt gcc att cgg tac cgt ggc gga gtg 211 Leu Leu Gly Ser Phe Gly Gly Gly Ala Ile Arg Tyr Arg Gly Gly Val              25 30 35 ctc gat gcg ttg ggg ctt aac ttc ctt gct ttt ggc cac gcg cag ggt 259 Leu Asp Ala Leu Gly Leu Asn Phe Leu Ala Phe Gly His Ala Gln Gly          40 45 50 att tcc aat acc gtg ttg tgg gtt ggg cag ctg ctg ctg att ggc gcg 307 Ile Ser Asn Thr Val Leu Trp Val Gly Gln Leu Leu Leu Ile Gly Ala      55 60 65 tgg gtt cac ctt gga cgt cgg ttg ttc aag aaa aaa gtc gct gat gac 355 Trp Val His Leu Gly Arg Arg Leu Phe Lys Lys Lys Val Ala Asp Asp  70 75 80 85 acc gca gac gct gct gac tta ggt ctt gta aag cgc acg ttg tat gcc 403 Thr Ala Asp Ala Ala Asp Leu Gly Leu Val Lys Arg Thr Leu Tyr Ala                  90 95 100 atg gtg gtg ccc ctc att ttt gcg gca cca atg atg tcg cgt gat gtt 451 Met Val Val Pro Leu Ile Phe Ala Ala Pro Met Met Ser Arg Asp Val             105 110 115 tat tcc tat ctc atg cag ggc gcg atg ctg cgt gat ggc ttc gat ccc 499 Tyr Ser Tyr Leu Met Gln Gly Ala Met Leu Arg Asp Gly Phe Asp Pro         120 125 130 tac act gag ggc gct gcg gta aac cct ggc ccc atg ttg ctt gag gtc 547 Tyr Thr Glu Gly Ala Ala Val Asn Pro Gly Pro Met Leu Leu Glu Val     135 140 145 tct cat gat tgg cgc aac acc acg acg ccg tat ggt cca cta cac ctg 595 Ser His Asp Trp Arg Asn Thr Thr Thr Pro Tyr Gly Pro Leu His Leu 150 155 160 165 tgg att gga gac atg atc acc acg gtt gtg ggc gat aat gtc acc ttg 643 Trp Ile Gly Asp Met Ile Thr Thr Val Val Gly Asp Asn Val Thr Leu                 170 175 180 ggc gtc gtc gct tac aag atc ttg tcg atc att ggc ctt gct gtg aca 691 Gly Val Val Ala Tyr Lys Ile Leu Ser Ile Ile Gly Leu Ala Val Thr             185 190 195 ggc tgg agc att gtc cgc att gca caa cat ttt gga gcc aac cca gca 739 Gly Trp Ser Ile Val Arg Ile Ala Gln His Phe Gly Ala Asn Pro Ala         200 205 210 att gca ttg tgg att ggt gtg gcc aat cct gtg atg atc atc cac atg 787 Ile Ala Leu Trp Ile Gly Val Ala Asn Pro Val Met Ile Ile His Met     215 220 225 atc ggc ggc atg cac aat gaa tcc ctc atg gtg gga ttg gtc agc gtc 835 Ile Gly Gly Met His Asn Glu Ser Leu Met Val Gly Leu Val Ser Val 230 235 240 245 ggc ttg ttg cta gca ctg aag aag cgt ttc gtg gca ggt gtg gca ctc 883 Gly Leu Leu Leu Ala Leu Lys Lys Arg Phe Val Ala Gly Val Ala Leu                 250 255 260 att gca gtg gct gtg tcg ctg aaa gct aca gcg gcg att gca ctt cct 931 Ile Ala Val Ala Val Ser Leu Lys Ala Thr Ala Ala Ile Ala Leu Pro             265 270 275 ttt gtg gtg tgg atc ggc atg cat cat ttc gca gga ttc tta gcc acc 979 Phe Val Val Trp Ile Gly Met His His Phe Ala Gly Phe Leu Ala Thr         280 285 290 aaa aag ggc aaa gac tcc cct acc ctt aag caa cag gtc ccc gcg ttc 1027 Lys Lys Gly Lys Asp Ser Pro Thr Leu Lys Gln Gln Val Pro Ala Phe     295 300 305 ttt gcc act gga gct gca ggt gtt gct gtc act ggt gtt gtt gtc agt 1075 Phe Ala Thr Gly Ala Ala Gly Val Ala Val Thr Gly Val Val Val Ser 310 315 320 325 gcg atc act tgg gcg tct ggc gct tcg tgg ggc tgg atc agt gag atc 1123 Ala Ile Thr Trp Ala Ser Gly Ala Ser Trp Gly Trp Ile Ser Glu Ile                 330 335 340 agt ggc aac agc aag gta atc aac ccg ctg gct ttc cct tct ttg gtg 1171 Ser Gly Asn Ser Lys Val Ile Asn Pro Leu Ala Phe Pro Ser Leu Val             345 350 355 gcc agt gtg atc acc atg gtg gct gaa gtg ttc gtt gac gat ttc gac 1219 Ala Ser Val Ile Thr Met Val Ala Glu Val Phe Val Asp Asp Phe Asp         360 365 370 tac aac gca gtg gtt aat gtt gtg cgc tca atc tcc atg ctg atc atg 1267 Tyr Asn Ala Val Val Asn Val Val Arg Ser Ile Ser Met Leu Ile Met     375 380 385 ctt ggc ggg ttg gtc gta tgt tgg tgg ctg ttc cgc cag aac gaa cgc 1315 Leu Gly Gly Leu Val Val Cys Trp Trp Leu Phe Arg Gln Asn Glu Arg 390 395 400 405 agg gcg gtc act ggt aca gca gcg gct tat gcc gtg gct ttt gtg ttc 1363 Arg Ala Val Thr Gly Thr Ala Ala Ala Tyr Ala Val Ala Phe Val Phe                 410 415 420 aat tct gtg acc ttg ccg tgg tac tac gcc agc ttg atc tct ttg ctc 1411 Asn Ser Val Thr Leu Pro Trp Tyr Tyr Ala Ser Leu Ile Ser Leu Leu             425 430 435 ggc aca ttt aaa cca ccg atg tgg ttg att cgc ttc gca gcg ggt gct 1459 Gly Thr Phe Lys Pro Pro Met Trp Leu Ile Arg Phe Ala Ala Gly Ala         440 445 450 tcg gtg ttt atc gcg ctg atg ttt acc gga agt gga aac cac cag ctg 1507 Ser Val Phe Ile Ala Leu Met Phe Thr Gly Ser Gly Asn His Gln Leu     455 460 465 tac aac atc gtt acg gtg atc atc gca gca att atc gcg tgg ctt gcc 1555 Tyr Asn Ile Val Thr Val Ile Ile Ala Ile Ile Ala Trp Leu Ala 470 475 480 485 acc gtg gtg atc ttt gat gac act gac cct gca aca acg gcc acg gag 1603 Thr Val Val Ile Phe Asp Asp Thr Asp Pro Ala Thr Thr Ala Thr Glu                 490 495 500 aaa ccc tcc ccg cat acc gtt tcc tagttgcata aggtaaaccg cca 1650 Lys Pro Ser Pro His Thr Val Ser             505 <210> 282 <211> 509 <212> PRT <213> Corynebacterium glutamicum <400> 282 Met Thr Leu Phe Gln Arg Leu Thr Asn Pro Val Val Leu Gly Gly Leu   1 5 10 15 Ala Gly Val Leu Leu Leu Leu Gly Ser Phe Gly Gly Gly Ala Ile Arg              20 25 30 Tyr Arg Gly Gly Val Leu Asp Ala Leu Gly Leu Asn Phe Leu Ala Phe          35 40 45 Gly His Ala Gln Gly Ile Ser Asn Thr Val Leu Trp Val Gly Gln Leu      50 55 60 Leu Leu Ile Gly Ala Trp Val His Leu Gly Arg Arg Leu Phe Lys Lys  65 70 75 80 Lys Val Ala Asp Asp Thr Ala Asp Ala Ala Asp Leu Gly Leu Val Lys                  85 90 95 Arg Thr Leu Tyr Ala Met Val Val Pro Leu Ile Phe Ala Ala Pro Met             100 105 110 Met Ser Arg Asp Val Tyr Ser Tyr Leu Met Gln Gly Ala Met Leu Arg         115 120 125 Asp Gly Phe Asp Pro Tyr Thr Glu Gly Ala Ala Val Asn Pro Gly Pro     130 135 140 Met Leu Leu Glu Val Ser His Asp Trp Arg Asn Thr Thr Thr Pro Tyr 145 150 155 160 Gly Pro Leu His Leu Trp Ile Gly Asp Met Ile Thr Thr Val Val Val Gly                 165 170 175 Asp Asn Val Thr Leu Gly Val Val Ala Tyr Lys Ile Leu Ser Ile Ile             180 185 190 Gly Leu Ala Val Thr Gly Trp Ser Ile Val Arg Ile Ala Gln His Phe         195 200 205 Gly Ala Asn Pro Ala Ile Ala Leu Trp Ile Gly Val Ala Asn Pro Val     210 215 220 Met Ile Ile His Met Ile Gly Gly Met His Asn Glu Ser Leu Met Val 225 230 235 240 Gly Leu Val Ser Val Gly Leu Leu Leu Ala Leu Lys Lys Arg Phe Val                 245 250 255 Ala Gly Val Ala Leu Ile Ala Val Ala Val Ser Leu Lys Ala Thr Ala             260 265 270 Ala Ile Ala Leu Pro Phe Val Val Trp Ile Gly Met His His Phe Ala         275 280 285 Gly Phe Leu Ala Thr Lys Lys Gly Lys Asp Ser Pro Thr Leu Lys Gln     290 295 300 Gln Val Pro Ala Phe Phe Ala Thr Gly Ala Ala Gly Val Ala Val Thr 305 310 315 320 Gly Val Val Val Ser Ala Ile Thr Trp Ala Ser Gly Ala Ser Trp Gly                 325 330 335 Trp Ile Ser Glu Ile Ser Gly Asn Ser Lys Val Ile Asn Pro Leu Ala             340 345 350 Phe Pro Ser Leu Val Ala Ser Val Ile Thr Met Val Ala Glu Val Phe         355 360 365 Val Asp Asp Phe Asp Tyr Asn Ala Val Val Asn Val Val Arg Ser Ile     370 375 380 Ser Met Leu Ile Met Leu Gly Gly Leu Val Val Cys Trp Trp Leu Phe 385 390 395 400 Arg Gln Asn Glu Arg Arg Ala Val Thr Gly Thr Ala Ala Ala Tyr Ala                 405 410 415 Val Ala Phe Val Phe Asn Ser Val Thr Leu Pro Trp Tyr Tyr Ala Ser             420 425 430 Leu Ile Ser Leu Leu Gly Thr Phe Lys Pro Pro Met Trp Leu Ile Arg         435 440 445 Phe Ala Ala Gly Ala Ser Val Phe Ile Ala Leu Met Phe Thr Gly Ser     450 455 460 Gly Asn His Gln Leu Tyr Asn Ile Val Thr Val Ile Ala Ala Ile 465 470 475 480 Ile Ala Trp Leu Ala Thr Val Val Ile Phe Asp Asp Thr Asp Pro Ala                 485 490 495 Thr Thr Ala Thr Glu Lys Pro Ser Pro His Thr Val Ser             500 505 <210> 283 <211> 1298 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (1275) <223> RXN01946 <400> 283 atc cgc aag tac tcc agg ctc gag gaa caa ttc cag tcg ctc ggc ggc 48 Ile Arg Lys Tyr Ser Arg Leu Glu Glu Gln Phe Gln Ser Leu Gly Gly   1 5 10 15 tac gaa gct gac gcc gaa gca gcc cag atc tgc gac aac ctc ggc ctc 96 Tyr Glu Ala Asp Ala Glu Ala Ala Gln Ile Cys Asp Asn Leu Gly Leu              20 25 30 gag gca cgc atc ctc gac cag cag ctt aaa acc ctg tcc ggc ggc cag 144 Glu Ala Arg Ile Leu Asp Gln Gln Leu Lys Thr Leu Ser Gly Gly Gln          35 40 45 cgc cgc cgc gtc gag ttg gcg cag atc ctc ttc gcc gcc acc aac ggc 192 Arg Arg Arg Val Glu Leu Ala Gln Ile Leu Phe Ala Ala Thr Asn Gly      50 55 60 tcc ggc aaa tca aaa acc aca ttg ctt ctc gac gag ccc acc aac cac 240 Ser Gly Lys Ser Lys Thr Thr Leu Leu Leu Asp Glu Pro Thr Asn His  65 70 75 80 ttg gac gca gac tcg atc acc tgg ctc cgt gac ttc ctg gcg aag cac 288 Leu Asp Ala Asp Ser Ile Thr Trp Leu Arg Asp Phe Leu Ala Lys His                  85 90 95 gaa ggt gga ctg atc atg att tcg cac gac gtc gaa ctg ctt ggc gcc 336 Glu Gly Gly Leu Ile Met Ile Ser His Asp Val Glu Leu Leu Gly Ala             100 105 110 gta tgt aac aag att tgg tac ctc gac gca gta cgc agc gaa gcc gat 384 Val Cys Asn Lys Ile Trp Tyr Leu Asp Ala Val Arg Ser Glu Ala Asp         115 120 125 gtc tac aac atg ggc ttt agc aaa tac gtc gat gca cgt gca ctc gat 432 Val Tyr Asn Met Gly Phe Ser Lys Tyr Val Asp Ala Arg Ala Leu Asp     130 135 140 gaa gca cgc cga cgc cgt gag cgc gca aac gcc gaa aag aag gcc gga 480 Glu Ala Arg Arg Arg Arg Glu Arg Ala Asn Ala Glu Lys Lys Lyla Ala Gly 145 150 155 160 gcc ctc aag gac cag gct gca cgc ctc ggc gcg aaa gca acc aag gct 528 Ala Leu Lys Asp Gln Ala Ala Arg Leu Gly Ala Lys Ala Thr Lys Ala                 165 170 175 gcc gca gct aag cag atg atc gcc cgt gcg gaa cga atg atc gac aac 576 Ala Ala Ala Lys Gln Met Ile Ala Arg Ala Glu Arg Met Ile Asp Asn             180 185 190 ctc gac gaa atc cgc gta gct gac cgc gcc gcc aac atc gtt ttc cca 624 Leu Asp Glu Ile Arg Val Ala Asp Arg Ala Ala Asn Ile Val Phe Pro         195 200 205 gaa cca gca ccc tgt gga aaa acc cca ctc aac gcc aag ggc ctg acc 672 Glu Pro Ala Pro Cys Gly Lys Thr Pro Leu Asn Ala Lys Gly Leu Thr     210 215 220 aag atg tac ggc tcc ctc gaa gtc ttc gcc ggc gtc gac cta gcc atc 720 Lys Met Tyr Gly Ser Leu Glu Val Phe Ala Gly Val Asp Leu Ala Ile 225 230 235 240 gac aaa ggc tcc cgc gta gtc gtc ctc gga ttc aac ggt gca ggt aaa 768 Asp Lys Gly Ser Arg Val Val Val Leu Gly Phe Asn Gly Ala Gly Lys                 245 250 255 acc acc ctg ctc aaa ctc ctc gcc ggt gtg gaa cgc acc gac ggc gaa 816 Thr Thr Leu Leu Lys Leu Leu Ala Gly Val Glu Arg Thr Asp Gly Glu             260 265 270 ggc ggc atc gtc acc gga tac ggc ctc aaa atc ggc tac ttc gcc cag 864 Gly Gly Ile Val Thr Gly Tyr Gly Leu Lys Ile Gly Tyr Phe Ala Gln         275 280 285 gaa cac gac acc atc gac ccc gac aaa tcc gtc tgg caa aac acc atc 912 Glu His Asp Thr Ile Asp Pro Asp Lys Ser Val Trp Gln Asn Thr Ile     290 295 300 gaa gcc tgc gcc gac gcc gac caa caa agc ctc cgc agc ctc ctc gga 960 Glu Ala Cys Ala Asp Ala Asp Gln Gln Ser Leu Arg Ser Leu Leu Gly 305 310 315 320 tcc ttc atg ttc tcc ggc gaa caa ctc gac caa cca gca gga aca ctc 1008 Ser Phe Met Phe Ser Gly Glu Gln Leu Asp Gln Pro Ala Gly Thr Leu                 325 330 335 tcc ggc ggt gaa aaa acc cgc ctc gca ctg gcc acc ctc gtg tcc tcc 1056 Ser Gly Gly Glu Lys Thr Arg Leu Ala Leu Ala Thr Leu Val Ser Ser             340 345 350 cgc gca aac gtc ctg ctt ctc gac gag ccc acc aac aac ctt gac ccg 1104 Arg Ala Asn Val Leu Leu Leu Asp Glu Pro Thr Asn Asn Leu Asp Pro         355 360 365 atc tcc cgc gaa cag gtc ctc gac gca ctg cgc acc tac acc ggc gca 1152 Ile Ser Arg Glu Gln Val Leu Asp Ala Leu Arg Thr Tyr Thr Gly Ala     370 375 380 gtc gtc ctg gtt acc cac gac ccg ggt gca gtc aag gcc ctt gag cca 1200 Val Val Leu Val Thr His Asp Pro Gly Ala Val Lys Ala Leu Glu Pro 385 390 395 400 gaa cgc gtc atc gtg ctt cct gat ggc acc gag gat ctt tgg aat gat 1248 Glu Arg Val Ile Val Leu Pro Asp Gly Thr Glu Asp Leu Trp Asn Asp                 405 410 415 cag tac atg gaa atc gtg gaa ttg gcg taggttctaa ggctgtttat 1295 Gln Tyr Met Glu Ile Val Glu Leu Ala             420 425 gct 1298 <210> 284 <211> 425 <212> PRT <213> Corynebacterium glutamicum <400> 284 Ile Arg Lys Tyr Ser Arg Leu Glu Glu Gln Phe Gln Ser Leu Gly Gly   1 5 10 15 Tyr Glu Ala Asp Ala Glu Ala Ala Gln Ile Cys Asp Asn Leu Gly Leu              20 25 30 Glu Ala Arg Ile Leu Asp Gln Gln Leu Lys Thr Leu Ser Gly Gly Gln          35 40 45 Arg Arg Arg Val Glu Leu Ala Gln Ile Leu Phe Ala Ala Thr Asn Gly      50 55 60 Ser Gly Lys Ser Lys Thr Thr Leu Leu Leu Asp Glu Pro Thr Asn His  65 70 75 80 Leu Asp Ala Asp Ser Ile Thr Trp Leu Arg Asp Phe Leu Ala Lys His                  85 90 95 Glu Gly Gly Leu Ile Met Ile Ser His Asp Val Glu Leu Leu Gly Ala             100 105 110 Val Cys Asn Lys Ile Trp Tyr Leu Asp Ala Val Arg Ser Glu Ala Asp         115 120 125 Val Tyr Asn Met Gly Phe Ser Lys Tyr Val Asp Ala Arg Ala Leu Asp     130 135 140 Glu Ala Arg Arg Arg Arg Glu Arg Ala Asn Ala Glu Lys Lys Lyla Ala Gly 145 150 155 160 Ala Leu Lys Asp Gln Ala Ala Arg Leu Gly Ala Lys Ala Thr Lys Ala                 165 170 175 Ala Ala Ala Lys Gln Met Ile Ala Arg Ala Glu Arg Met Ile Asp Asn             180 185 190 Leu Asp Glu Ile Arg Val Ala Asp Arg Ala Ala Asn Ile Val Phe Pro         195 200 205 Glu Pro Ala Pro Cys Gly Lys Thr Pro Leu Asn Ala Lys Gly Leu Thr     210 215 220 Lys Met Tyr Gly Ser Leu Glu Val Phe Ala Gly Val Asp Leu Ala Ile 225 230 235 240 Asp Lys Gly Ser Arg Val Val Val Leu Gly Phe Asn Gly Ala Gly Lys                 245 250 255 Thr Thr Leu Leu Lys Leu Leu Ala Gly Val Glu Arg Thr Asp Gly Glu             260 265 270 Gly Gly Ile Val Thr Gly Tyr Gly Leu Lys Ile Gly Tyr Phe Ala Gln         275 280 285 Glu His Asp Thr Ile Asp Pro Asp Lys Ser Val Trp Gln Asn Thr Ile     290 295 300 Glu Ala Cys Ala Asp Ala Asp Gln Gln Ser Leu Arg Ser Leu Leu Gly 305 310 315 320 Ser Phe Met Phe Ser Gly Glu Gln Leu Asp Gln Pro Ala Gly Thr Leu                 325 330 335 Ser Gly Gly Glu Lys Thr Arg Leu Ala Leu Ala Thr Leu Val Ser Ser             340 345 350 Arg Ala Asn Val Leu Leu Leu Asp Glu Pro Thr Asn Asn Leu Asp Pro         355 360 365 Ile Ser Arg Glu Gln Val Leu Asp Ala Leu Arg Thr Tyr Thr Gly Ala     370 375 380 Val Val Leu Val Thr His Asp Pro Gly Ala Val Lys Ala Leu Glu Pro 385 390 395 400 Glu Arg Val Ile Val Leu Pro Asp Gly Thr Glu Asp Leu Trp Asn Asp                 405 410 415 Gln Tyr Met Glu Ile Val Glu Leu Ala             420 425 <210> 285 <211> 1298 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (1275) <223> FRXA01946 <400> 285 atc cgc aag tac tcc agg ctc gag gaa caa ttc cag tcg ctc ggc ggc 48 Ile Arg Lys Tyr Ser Arg Leu Glu Glu Gln Phe Gln Ser Leu Gly Gly   1 5 10 15 tac gaa gct gac gcc gaa gca gcc cag atc tgc gac aac ctc ggc ctc 96 Tyr Glu Ala Asp Ala Glu Ala Ala Gln Ile Cys Asp Asn Leu Gly Leu              20 25 30 gag gca cgc atc ctc gac cag cag ctt aaa acc ctg tcc ggc ggc cag 144 Glu Ala Arg Ile Leu Asp Gln Gln Leu Lys Thr Leu Ser Gly Gly Gln          35 40 45 cgc cgc cgc gtc gag ttg gcg cag atc ctc ttc gcc gcc acc aac ggc 192 Arg Arg Arg Val Glu Leu Ala Gln Ile Leu Phe Ala Ala Thr Asn Gly      50 55 60 tcc ggc aaa tca aaa acc aca ttg ctt ctc gac gag ccc acc aac cac 240 Ser Gly Lys Ser Lys Thr Thr Leu Leu Leu Asp Glu Pro Thr Asn His  65 70 75 80 ttg gac gca gac tcg atc acc tgg ctc cgt gac ttc ctg gcg aag cac 288 Leu Asp Ala Asp Ser Ile Thr Trp Leu Arg Asp Phe Leu Ala Lys His                  85 90 95 gaa ggt gga ctg atc atg att tcg cac gac gtc gaa ctg ctt ggc gcc 336 Glu Gly Gly Leu Ile Met Ile Ser His Asp Val Glu Leu Leu Gly Ala             100 105 110 gta tgt aac aag att tgg tac ctc gac gca gta cgc agc gaa gcc gat 384 Val Cys Asn Lys Ile Trp Tyr Leu Asp Ala Val Arg Ser Glu Ala Asp         115 120 125 gtc tac aac atg ggc ttt agc aaa tac gtc gat gca cgt gca ctc gat 432 Val Tyr Asn Met Gly Phe Ser Lys Tyr Val Asp Ala Arg Ala Leu Asp     130 135 140 gaa gca cgc cga cgc cgt gag cgc gca aac gcc gaa aag aag gcc gga 480 Glu Ala Arg Arg Arg Arg Glu Arg Ala Asn Ala Glu Lys Lys Lyla Ala Gly 145 150 155 160 gcc ctc aag gac cag gct gca cgc ctc ggc gcg aaa gca acc aag gct 528 Ala Leu Lys Asp Gln Ala Ala Arg Leu Gly Ala Lys Ala Thr Lys Ala                 165 170 175 gcc gca gct aag cag atg atc gcc cgt gcg gaa cga atg atc gac aac 576 Ala Ala Ala Lys Gln Met Ile Ala Arg Ala Glu Arg Met Ile Asp Asn             180 185 190 ctc gac gaa atc cgc gta gct gac cgc gcc gcc aac atc gtt ttc cca 624 Leu Asp Glu Ile Arg Val Ala Asp Arg Ala Ala Asn Ile Val Phe Pro         195 200 205 gaa cca gca ccc tgt gga aaa acc cca ctc aac gcc aag ggc ctg acc 672 Glu Pro Ala Pro Cys Gly Lys Thr Pro Leu Asn Ala Lys Gly Leu Thr     210 215 220 aag atg tac ggc tcc ctc gaa gtc ttc gcc ggc gtc gac cta gcc atc 720 Lys Met Tyr Gly Ser Leu Glu Val Phe Ala Gly Val Asp Leu Ala Ile 225 230 235 240 gac aaa ggc tcc cgc gta gtc gtc ctc gga ttc aac ggt gca ggt aaa 768 Asp Lys Gly Ser Arg Val Val Val Leu Gly Phe Asn Gly Ala Gly Lys                 245 250 255 acc acc ctg ctc aaa ctc ctc gcc ggt gtg gaa cgc acc gac ggc gaa 816 Thr Thr Leu Leu Lys Leu Leu Ala Gly Val Glu Arg Thr Asp Gly Glu             260 265 270 ggc ggc atc gtc acc gga tac ggc ctc aaa atc ggc tac ttc gcc cag 864 Gly Gly Ile Val Thr Gly Tyr Gly Leu Lys Ile Gly Tyr Phe Ala Gln         275 280 285 gaa cac gac acc atc gac ccc gac aaa tcc gtc tgg caa aac acc atc 912 Glu His Asp Thr Ile Asp Pro Asp Lys Ser Val Trp Gln Asn Thr Ile     290 295 300 gaa gcc tgc gcc gac gcc gac caa caa agc ctc cgc agc ctc ctc gga 960 Glu Ala Cys Ala Asp Ala Asp Gln Gln Ser Leu Arg Ser Leu Leu Gly 305 310 315 320 tcc ttc atg ttc tcc ggc gaa caa ctc gac caa cca gca gga aca ctc 1008 Ser Phe Met Phe Ser Gly Glu Gln Leu Asp Gln Pro Ala Gly Thr Leu                 325 330 335 tcc ggc ggt gaa aaa acc cgc ctc gca ctg gcc acc ctc gtg tcc tcc 1056 Ser Gly Gly Glu Lys Thr Arg Leu Ala Leu Ala Thr Leu Val Ser Ser             340 345 350 cgc gca aac gtc ctg ctt ctc gac gag ccc acc aac aac ctt gac ccg 1104 Arg Ala Asn Val Leu Leu Leu Asp Glu Pro Thr Asn Asn Leu Asp Pro         355 360 365 atc tcc cgc gaa cag gtc ctc gac gca ctg cgc acc tac acc ggc gca 1152 Ile Ser Arg Glu Gln Val Leu Asp Ala Leu Arg Thr Tyr Thr Gly Ala     370 375 380 gtc gtc ctg gtt acc cac gac ccg ggt gca gtc aag gcc ctt gag cca 1200 Val Val Leu Val Thr His Asp Pro Gly Ala Val Lys Ala Leu Glu Pro 385 390 395 400 gaa cgc gtc atc gtg ctt cct gat ggc acc gag gat ctt tgg aat gat 1248 Glu Arg Val Ile Val Leu Pro Asp Gly Thr Glu Asp Leu Trp Asn Asp                 405 410 415 cag tac atg gaa atc gtg gaa ttg gcg taggttctaa ggctgtttat 1295 Gln Tyr Met Glu Ile Val Glu Leu Ala             420 425 gct 1298 <210> 286 <211> 425 <212> PRT <213> Corynebacterium glutamicum <400> 286 Ile Arg Lys Tyr Ser Arg Leu Glu Glu Gln Phe Gln Ser Leu Gly Gly   1 5 10 15 Tyr Glu Ala Asp Ala Glu Ala Ala Gln Ile Cys Asp Asn Leu Gly Leu              20 25 30 Glu Ala Arg Ile Leu Asp Gln Gln Leu Lys Thr Leu Ser Gly Gly Gln          35 40 45 Arg Arg Arg Val Glu Leu Ala Gln Ile Leu Phe Ala Ala Thr Asn Gly      50 55 60 Ser Gly Lys Ser Lys Thr Thr Leu Leu Leu Asp Glu Pro Thr Asn His  65 70 75 80 Leu Asp Ala Asp Ser Ile Thr Trp Leu Arg Asp Phe Leu Ala Lys His                  85 90 95 Glu Gly Gly Leu Ile Met Ile Ser His Asp Val Glu Leu Leu Gly Ala             100 105 110 Val Cys Asn Lys Ile Trp Tyr Leu Asp Ala Val Arg Ser Glu Ala Asp         115 120 125 Val Tyr Asn Met Gly Phe Ser Lys Tyr Val Asp Ala Arg Ala Leu Asp     130 135 140 Glu Ala Arg Arg Arg Arg Glu Arg Ala Asn Ala Glu Lys Lys Lyla Ala Gly 145 150 155 160 Ala Leu Lys Asp Gln Ala Ala Arg Leu Gly Ala Lys Ala Thr Lys Ala                 165 170 175 Ala Ala Ala Lys Gln Met Ile Ala Arg Ala Glu Arg Met Ile Asp Asn             180 185 190 Leu Asp Glu Ile Arg Val Ala Asp Arg Ala Ala Asn Ile Val Phe Pro         195 200 205 Glu Pro Ala Pro Cys Gly Lys Thr Pro Leu Asn Ala Lys Gly Leu Thr     210 215 220 Lys Met Tyr Gly Ser Leu Glu Val Phe Ala Gly Val Asp Leu Ala Ile 225 230 235 240 Asp Lys Gly Ser Arg Val Val Val Leu Gly Phe Asn Gly Ala Gly Lys                 245 250 255 Thr Thr Leu Leu Lys Leu Leu Ala Gly Val Glu Arg Thr Asp Gly Glu             260 265 270 Gly Gly Ile Val Thr Gly Tyr Gly Leu Lys Ile Gly Tyr Phe Ala Gln         275 280 285 Glu His Asp Thr Ile Asp Pro Asp Lys Ser Val Trp Gln Asn Thr Ile     290 295 300 Glu Ala Cys Ala Asp Ala Asp Gln Gln Ser Leu Arg Ser Leu Leu Gly 305 310 315 320 Ser Phe Met Phe Ser Gly Glu Gln Leu Asp Gln Pro Ala Gly Thr Leu                 325 330 335 Ser Gly Gly Glu Lys Thr Arg Leu Ala Leu Ala Thr Leu Val Ser Ser             340 345 350 Arg Ala Asn Val Leu Leu Leu Asp Glu Pro Thr Asn Asn Leu Asp Pro         355 360 365 Ile Ser Arg Glu Gln Val Leu Asp Ala Leu Arg Thr Tyr Thr Gly Ala     370 375 380 Val Val Leu Val Thr His Asp Pro Gly Ala Val Lys Ala Leu Glu Pro 385 390 395 400 Glu Arg Val Ile Val Leu Pro Asp Gly Thr Glu Asp Leu Trp Asn Asp                 405 410 415 Gln Tyr Met Glu Ile Val Glu Leu Ala             420 425 <210> 287 <211> 1812 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1789) <223> RXN00164 <400> 287 ctgctttgcg ggaggttatg aaatgagtgg ggagacgtcg aaaagcatgc gctttccgtt 60 ggccagcctg ccgcaagtgc ggcgcgaggt ggcccggcag gtg ggt cgt att ccg 115                                             Val Gly Arg Ile Pro                                               1 5 cgg gcg aag tgg tgg ttt tta ggc gcg ctg gtg ttg ctg agt gcg ggc 163 Arg Ala Lys Trp Trp Phe Leu Gly Ala Leu Val Leu Leu Ser Ala Gly                  10 15 20 gct tat gcg tcg gtg ctg gtg ccg cag gtg ctg ggg cgg att gtg gat 211 Ala Tyr Ala Ser Val Leu Val Pro Gln Val Leu Gly Arg Ile Val Asp              25 30 35 ctg gtg tcc gat ggc gcg cag atg cgt gat ttt gtt gag ctc agt gtg 259 Leu Val Ser Asp Gly Ala Gln Met Arg Asp Phe Val Glu Leu Ser Val          40 45 50 att ctc att gcg gtg gca att gcc ggc gcg gtg ctc agt gcg tgc ggg 307 Ile Leu Ile Ala Val Ala Ile Ala Gly Ala Val Leu Ser Ala Cys Gly      55 60 65 ttc tat gtg gtg tcg cgg att tct gag aag att atc gcc aat ttg agg 355 Phe Tyr Val Val Ser Arg Ile Ser Glu Lys Ile Ile Ala Asn Leu Arg  70 75 80 85 gaa gat atg gtg ggc acc gcg ctt ggg ttg ccc acg cac cag gtg gaa 403 Glu Asp Met Val Gly Thr Ala Leu Gly Leu Pro Thr His Gln Val Glu                  90 95 100 gat gcg ggc tct ggc gat ttg gtg agc cgc tcc acc gat gat gtc tcc 451 Asp Ala Gly Ser Gly Asp Leu Val Ser Arg Ser Thr Asp Asp Val Ser             105 110 115 gag cta tcc gca gcg gtg aca gag acc gtc ccg att tta agt tcc tca 499 Glu Leu Ser Ala Ala Val Thr Glu Thr Val Pro Ile Leu Ser Ser Ser         120 125 130 ctg ttt acc att gcc gcg acg atc att gcg ctg ttt tct ttg gac tgg 547 Leu Phe Thr Ile Ala Ala Thr Ile Ala Leu Phe Ser Leu Asp Trp     135 140 145 caa ttt gtg ctc att cct gtc gtg gtg gcg ccg gtg tac tac ttc gcg 595 Gln Phe Val Leu Ile Pro Val Val Ala Pro Val Tyr Tyr Phe Ala 150 155 160 165 tcc aag cac tat ttg agc aag gcg ccg gat cgg tat gcg gca gaa cgc 643 Ser Lys His Tyr Leu Ser Lys Ala Pro Asp Arg Tyr Ala Ala Glu Arg                 170 175 180 gcg gcg atg gcg gag cgt gcg cga aag gta ctt gag gct att cgc ggg 691 Ala Ala Met Ala Glu Arg Ala Arg Lys Val Leu Glu Ala Ile Arg Gly             185 190 195 cgt gca act gtg cgg gcg tat tcc atg gaa gat gcc atg cat aat cag 739 Arg Ala Thr Val Arg Ala Tyr Ser Met Glu Asp Ala Met His Asn Gln         200 205 210 att gat cag gcg tcg tgg tct gtg gtg gtc aag ggt att cgt gcg cgc 787 Ile Asp Gln Ala Ser Trp Ser Val Val Val Lys Gly Ile Arg Ala Arg     215 220 225 acc acc atg ttg att ttg aac atg tgg atg ctg ttt gcg gaa ttc ctc 835 Thr Thr Met Leu Ile Leu Asn Met Trp Met Leu Phe Ala Glu Phe Leu 230 235 240 245 atg ctc gcg gtc gcg ttg gtg atc ggc tac aag ctg gtc att gat aat 883 Met Leu Ala Val Ala Leu Val Ile Gly Tyr Lys Leu Val Ile Asp Asn                 250 255 260 gcg ctg acg atc ggc gcg gtt acc ggt gcc gtg ctg atg att att cgt 931 Ala Leu Thr Ile Gly Ala Val Thr Gly Ala Val Leu Met Ile Ile Arg             265 270 275 ctg cgt ggc ccg atg aat atg ttc atg cgc gtg ctc gac acc att caa 979 Leu Arg Gly Pro Met Asn Met Phe Met Arg Val Leu Asp Thr Ile Gln         280 285 290 tcc ggc tat gcg tcg ctg gcg cgc atc gtg gga gtt gtt gcg gat ccg 1027 Ser Gly Tyr Ala Ser Leu Ala Arg Ile Val Gly Val Val Ala Asp Pro     295 300 305 ccg att cct gtg ccc gac agc ggt gtg aaa gca cct cag ggc aaa gtg 1075 Pro Ile Pro Val Pro Asp Ser Gly Val Lys Ala Pro Gln Gly Lys Val 310 315 320 325 gaa ttg cgc aac gtc agc ttt agc tat ggc gat tcc tgg gcg gtg aaa 1123 Glu Leu Arg Asn Val Ser Phe Ser Tyr Gly Asp Ser Trp Ala Val Lys                 330 335 340 gac atc gac atc acg atc aat tcc ggc gaa act gtc gcg ctc gtg ggc 1171 Asp Ile Asp Ile Thr Ile Asn Ser Gly Glu Thr Val Ala Leu Val Gly             345 350 355 gca tct ggc gca ggt aag acg acg gtc gcc gcc ttg ctg gcg ggc ttg 1219 Ala Ser Gly Ala Gly Lys Thr Thr Val Ala Ala Leu Leu Ala Gly Leu         360 365 370 cgg gtg cca gat caa ggg caa gtg ctt gtc gac gac ttc ccc gtc tct 1267 Arg Val Pro Asp Gln Gly Gln Val Leu Val Asp Asp Phe Pro Val Ser     375 380 385 cac ctc tct gac cgc gag cgt atc gcc cgc ttg gcc atg gtc agc cag 1315 His Leu Ser Asp Arg Glu Arg Ile Ala Arg Leu Ala Met Val Ser Gln 390 395 400 405 gag gtt cat gtt ttc tcc ggc acg ctg cgc cag gat ctc acc ttg gct 1363 Glu Val His Val Phe Ser Gly Thr Leu Arg Gln Asp Leu Thr Leu Ala                 410 415 420 aaa cca gat gcc tcc gat gag gaa tta gcg cat gct ctt ggg caa gtt 1411 Lys Pro Asp Ala Ser Asp Glu Glu Leu Ala His Ala Leu Gly Gln Val             425 430 435 aat gcc ctt gac tgg ttg gag agt ctt cca gaa gga ctg gac acg gtc 1459 Asn Ala Leu Asp Trp Leu Glu Ser Leu Pro Glu Gly Leu Asp Thr Val         440 445 450 gtt ggt gcg cga gga atc cag cta gaa cca gtg gtg gct cag cag ttg 1507 Val Gly Ala Arg Gly Ile Gln Leu Glu Pro Val Val Ala Gln Gln Leu     455 460 465 gcg ttg gcc cgg gtg ttg ttg ctc aat ccg gcg atc gtc atc atg gat 1555 Ala Leu Ala Arg Val Leu Leu Leu Asn Pro Ala Ile Val Ile Met Asp 470 475 480 485 gaa gcc acg gca gaa gca gga tcg gcg ggt gcc agc gca ctg gaa gag 1603 Glu Ala Thr Ala Glu Ala Gly Ser Ala Gly Ala Ser Ala Leu Glu Glu                 490 495 500 gct gca gat gca gtg agc aag aac cgt tcc gca ttg gtg gtg gcg cac 1651 Ala Ala Asp Ala Val Ser Lys Asn Arg Ser Ala Leu Val Val Ala His             505 510 515 cgg ttg gat cag gca tcg cgg gct gat cag att ctg gtg atg gat aag 1699 Arg Leu Asp Gln Ala Ser Arg Ala Asp Gln Ile Leu Val Met Asp Lys         520 525 530 ggg gag gtt gtg gaa tcc ggt act cac cag gag tta ttg gat cac ggg 1747 Gly Glu Val Val Glu Ser Gly Thr His Gln Glu Leu Leu Asp His Gly     535 540 545 ggt att tat cag cgt ctg tgg act gcg tgg agt gtc gga aga 1789 Gly Ile Tyr Gln Arg Leu Trp Thr Ala Trp Ser Val Gly Arg 550 555 560 tagttgactg ttcaatgcgt tga 1812 <210> 288 <211> 563 <212> PRT <213> Corynebacterium glutamicum <400> 288 Val Gly Arg Ile Pro Arg Ala Lys Trp Trp Phe Leu Gly Ala Leu Val   1 5 10 15 Leu Leu Ser Ala Gly Ala Tyr Ala Ser Val Leu Val Pro Gln Val Leu              20 25 30 Gly Arg Ile Val Asp Leu Val Ser Asp Gly Ala Gln Met Arg Asp Phe          35 40 45 Val Glu Leu Ser Val Ile Leu Ile Ala Val Ala Ile Ala Gly Ala Val      50 55 60 Leu Ser Ala Cys Gly Phe Tyr Val Val Ser Arg Ile Ser Glu Lys Ile  65 70 75 80 Ile Ala Asn Leu Arg Glu Asp Met Val Gly Thr Ala Leu Gly Leu Pro                  85 90 95 Thr His Gln Val Glu Asp Ala Gly Ser Gly Asp Leu Val Ser Arg Ser             100 105 110 Thr Asp Asp Val Ser Glu Leu Ser Ala Ala Val Thr Glu Thr Val Pro         115 120 125 Ile Leu Ser Ser Ser Leu Phe Thr Ile Ala Ala Thr Ile Ile Ala Leu     130 135 140 Phe Ser Leu Asp Trp Gln Phe Val Leu Ile Pro Val Val Val Ala Pro 145 150 155 160 Val Tyr Tyr Phe Ala Ser Lys His Tyr Leu Ser Lys Ala Pro Asp Arg                 165 170 175 Tyr Ala Ala Glu Arg Ala Ala Met Ala Glu Arg Ala Arg Lys Val Leu             180 185 190 Glu Ala Ile Arg Gly Arg Ala Thr Val Arg Ala Tyr Ser Met Glu Asp         195 200 205 Ala Met His Asn Gln Ile Asp Gln Ala Ser Trp Ser Val Val Val Lys     210 215 220 Gly Ile Arg Ala Arg Thr Thr Met Leu Ile Leu Asn Met Trp Met Leu 225 230 235 240 Phe Ala Glu Phe Leu Met Leu Ala Val Ala Leu Val Ile Gly Tyr Lys                 245 250 255 Leu Val Ile Asp Asn Ala Leu Thr Ile Gly Ala Val Thr Gly Ala Val             260 265 270 Leu Met Ile Ile Arg Leu Arg Gly Pro Met Asn Met Phe Met Arg Val         275 280 285 Leu Asp Thr Ile Gln Ser Gly Tyr Ala Ser Leu Ala Arg Ile Val Gly     290 295 300 Val Val Ala Asp Pro Pro Ile Pro Val Pro Asp Ser Gly Val Lys Ala 305 310 315 320 Pro Gln Gly Lys Val Glu Leu Arg Asn Val Ser Phe Ser Tyr Gly Asp                 325 330 335 Ser Trp Ala Val Lys Asp Ile Asp Ile Thr Ile Asn Ser Gly Glu Thr             340 345 350 Val Ala Leu Val Gly Ala Ser Gly Ala Gly Lys Thr Thr Val Ala Ala         355 360 365 Leu Leu Ala Gly Leu Arg Val Pro Asp Gln Gly Gln Val Leu Val Asp     370 375 380 Asp Phe Pro Val Ser His Leu Ser Asp Arg Glu Arg Ile Ala Arg Leu 385 390 395 400 Ala Met Val Ser Gln Glu Val His Val Phe Ser Gly Thr Leu Arg Gln                 405 410 415 Asp Leu Thr Leu Ala Lys Pro Asp Ala Ser Asp Glu Glu Leu Ala His             420 425 430 Ala Leu Gly Gln Val Asn Ala Leu Asp Trp Leu Glu Ser Leu Pro Glu         435 440 445 Gly Leu Asp Thr Val Val Gly Ala Arg Gly Ile Gln Leu Glu Pro Val     450 455 460 Val Ala Gln Gln Leu Ala Leu Ala Arg Val Leu Leu Leu Asn Pro Ala 465 470 475 480 Ile Val Ile Met Asp Glu Ala Thr Ala Glu Ala Gly Ser Ala Gly Ala                 485 490 495 Ser Ala Leu Glu Glu Ala Ala Asp Ala Val Ser Lys Asn Arg Ser Ala             500 505 510 Leu Val Val Ala His Arg Leu Asp Gln Ala Ser Arg Ala Asp Gln Ile         515 520 525 Leu Val Met Asp Lys Gly Glu Val Val Glu Ser Gly Thr His Gln Glu     530 535 540 Leu Leu Asp His Gly Gly Ile Tyr Gln Arg Leu Trp Thr Ala Trp Ser 545 550 555 560 Val Gly Arg <210> 289 <211> 1812 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1789) <223> FRXA00164 <400> 289 ctgctttgcg ggaggttatg aaatgagtgg ggagacgtcg aaaagcatgc gctttccgtt 60 ggccagcctg ccgcaagtgc ggcgcgaggt ggcccggcag gtg ggt cgt att ccg 115                                             Val Gly Arg Ile Pro                                               1 5 cgg gcg aag tgg tgg ttt tta ggc gcg ctg gtg ttg ctg agt gcg ggc 163 Arg Ala Lys Trp Trp Phe Leu Gly Ala Leu Val Leu Leu Ser Ala Gly                  10 15 20 gct tat gcg tcg gtg ctg gtg ccg cag gtg ctg ggg cgg att gtg gat 211 Ala Tyr Ala Ser Val Leu Val Pro Gln Val Leu Gly Arg Ile Val Asp              25 30 35 ctg gtg tcc gat ggc gcg cag atg cgt gat ttt gtt gag ctc agt gtg 259 Leu Val Ser Asp Gly Ala Gln Met Arg Asp Phe Val Glu Leu Ser Val          40 45 50 att ctc att gcg gtg gca att gcc ggc gcg gtg ctc agt gcg tgc ggg 307 Ile Leu Ile Ala Val Ala Ile Ala Gly Ala Val Leu Ser Ala Cys Gly      55 60 65 ttc tat gtg gtg tcg cgg att tct gag aag att atc gcc aat ttg agg 355 Phe Tyr Val Val Ser Arg Ile Ser Glu Lys Ile Ile Ala Asn Leu Arg  70 75 80 85 gaa gat atg gtg ggc acc gcg ctt ggg ttg ccc acg cac cag gtg gaa 403 Glu Asp Met Val Gly Thr Ala Leu Gly Leu Pro Thr His Gln Val Glu                  90 95 100 gat gcg ggc tct ggc gat ttg gtg agc cgc tcc acc gat gat gtc tcc 451 Asp Ala Gly Ser Gly Asp Leu Val Ser Arg Ser Thr Asp Asp Val Ser             105 110 115 gag cta tcc gca gcg gtg aca gag acc gtc ccg att tta agt tcc tca 499 Glu Leu Ser Ala Ala Val Thr Glu Thr Val Pro Ile Leu Ser Ser Ser         120 125 130 ctg ttt acc att gcc gcg acg atc att gcg ctg ttt tct ttg gac tgg 547 Leu Phe Thr Ile Ala Ala Thr Ile Ala Leu Phe Ser Leu Asp Trp     135 140 145 caa ttt gtg ctc att cct gtc gtg gtg gcg ccg gtg tac tac ttc gcg 595 Gln Phe Val Leu Ile Pro Val Val Ala Pro Val Tyr Tyr Phe Ala 150 155 160 165 tcc aag cac tat ttg agc aag gcg ccg gat cgg tat gcg gca gaa cgc 643 Ser Lys His Tyr Leu Ser Lys Ala Pro Asp Arg Tyr Ala Ala Glu Arg                 170 175 180 gcg gcg atg gcg gag cgt gcg cga aag gta ctt gag gct att cgc ggg 691 Ala Ala Met Ala Glu Arg Ala Arg Lys Val Leu Glu Ala Ile Arg Gly             185 190 195 cgt gca act gtg cgg gcg tat tcc atg gaa gat gcc atg cat aat cag 739 Arg Ala Thr Val Arg Ala Tyr Ser Met Glu Asp Ala Met His Asn Gln         200 205 210 att gat cag gcg tcg tgg tct gtg gtg gtc aag ggt att cgt gcg cgc 787 Ile Asp Gln Ala Ser Trp Ser Val Val Val Lys Gly Ile Arg Ala Arg     215 220 225 acc acc atg ttg att ttg aac atg tgg atg ctg ttt gcg gaa ttc ctc 835 Thr Thr Met Leu Ile Leu Asn Met Trp Met Leu Phe Ala Glu Phe Leu 230 235 240 245 atg ctc gcg gtc gcg ttg gtg atc ggc tac aag ctg gtc att gat aat 883 Met Leu Ala Val Ala Leu Val Ile Gly Tyr Lys Leu Val Ile Asp Asn                 250 255 260 gcg ctg acg atc ggc gcg gtt acc ggt gcc gtg ctg atg att att cgt 931 Ala Leu Thr Ile Gly Ala Val Thr Gly Ala Val Leu Met Ile Ile Arg             265 270 275 ctg cgt ggc ccg atg aat atg ttc atg cgc gtg ctc gac acc att caa 979 Leu Arg Gly Pro Met Asn Met Phe Met Arg Val Leu Asp Thr Ile Gln         280 285 290 tcc ggc tat gcg tcg ctg gcg cgc atc gtg gga gtt gtt gcg gat ccg 1027 Ser Gly Tyr Ala Ser Leu Ala Arg Ile Val Gly Val Val Ala Asp Pro     295 300 305 ccg att cct gtg ccc gac agc ggt gtg aaa gca cct cag ggc aaa gtg 1075 Pro Ile Pro Val Pro Asp Ser Gly Val Lys Ala Pro Gln Gly Lys Val 310 315 320 325 gaa ttg cgc aac gtc agc ttt agc tat ggc gat tcc tgg gcg gtg aaa 1123 Glu Leu Arg Asn Val Ser Phe Ser Tyr Gly Asp Ser Trp Ala Val Lys                 330 335 340 gac atc gac atc acg atc aat tcc ggc gaa act gtc gcg ctc gtg ggc 1171 Asp Ile Asp Ile Thr Ile Asn Ser Gly Glu Thr Val Ala Leu Val Gly             345 350 355 gca tct ggc gca ggt aag acg acg gtc gcc gcc ttg ctg gcg ggc ttg 1219 Ala Ser Gly Ala Gly Lys Thr Thr Val Ala Ala Leu Leu Ala Gly Leu         360 365 370 cgg gtg cca gat caa ggg caa gtg ctt gtc gac gac ttc ccc gtc tct 1267 Arg Val Pro Asp Gln Gly Gln Val Leu Val Asp Asp Phe Pro Val Ser     375 380 385 cac ctc tct gac cgc gag cgt atc gcc cgc ttg gcc atg gtc agc cag 1315 His Leu Ser Asp Arg Glu Arg Ile Ala Arg Leu Ala Met Val Ser Gln 390 395 400 405 gag gtt cat gtt ttc tcc ggc acg ctg cgc cag gat ctc acc ttg gct 1363 Glu Val His Val Phe Ser Gly Thr Leu Arg Gln Asp Leu Thr Leu Ala                 410 415 420 aaa cca gat gcc tcc gat gag gaa tta gcg cat gct ctt ggg caa gtt 1411 Lys Pro Asp Ala Ser Asp Glu Glu Leu Ala His Ala Leu Gly Gln Val             425 430 435 aat gcc ctt gac tgg ttg gag agt ctt cca gaa gga ctg gac acg gtc 1459 Asn Ala Leu Asp Trp Leu Glu Ser Leu Pro Glu Gly Leu Asp Thr Val         440 445 450 gtt ggt gcg cga gga atc cag cta gaa cca gtg gtg gct cag cag ttg 1507 Val Gly Ala Arg Gly Ile Gln Leu Glu Pro Val Val Ala Gln Gln Leu     455 460 465 gcg ttg gcc cgg gtg ttg ttg ctc aat ccg gcg atc gtc atc atg gat 1555 Ala Leu Ala Arg Val Leu Leu Leu Asn Pro Ala Ile Val Ile Met Asp 470 475 480 485 gaa gcc acg gca gaa gca gga tcg gcg ggt gcc agc gca ctg gaa gag 1603 Glu Ala Thr Ala Glu Ala Gly Ser Ala Gly Ala Ser Ala Leu Glu Glu                 490 495 500 gct gca gat gca gtg agc aag aac cgt tcc gca ttg gtg gtg gcg cac 1651 Ala Ala Asp Ala Val Ser Lys Asn Arg Ser Ala Leu Val Val Ala His             505 510 515 cgg ttg gat cag gca tcg cgg gct gat cag att ctg gtg atg gat aag 1699 Arg Leu Asp Gln Ala Ser Arg Ala Asp Gln Ile Leu Val Met Asp Lys         520 525 530 ggg gag gtt gtg gaa tcc ggt act cac cag gag tta ttg gat cac ggg 1747 Gly Glu Val Val Glu Ser Gly Thr His Gln Glu Leu Leu Asp His Gly     535 540 545 ggt att tat cag cgt ctg tgg act gcg tgg agt gtc gga aga 1789 Gly Ile Tyr Gln Arg Leu Trp Thr Ala Trp Ser Val Gly Arg 550 555 560 tagttgactg ttcaatgcgt tga 1812 <210> 290 <211> 563 <212> PRT <213> Corynebacterium glutamicum <400> 290 Val Gly Arg Ile Pro Arg Ala Lys Trp Trp Phe Leu Gly Ala Leu Val   1 5 10 15 Leu Leu Ser Ala Gly Ala Tyr Ala Ser Val Leu Val Pro Gln Val Leu              20 25 30 Gly Arg Ile Val Asp Leu Val Ser Asp Gly Ala Gln Met Arg Asp Phe          35 40 45 Val Glu Leu Ser Val Ile Leu Ile Ala Val Ala Ile Ala Gly Ala Val      50 55 60 Leu Ser Ala Cys Gly Phe Tyr Val Val Ser Arg Ile Ser Glu Lys Ile  65 70 75 80 Ile Ala Asn Leu Arg Glu Asp Met Val Gly Thr Ala Leu Gly Leu Pro                  85 90 95 Thr His Gln Val Glu Asp Ala Gly Ser Gly Asp Leu Val Ser Arg Ser             100 105 110 Thr Asp Asp Val Ser Glu Leu Ser Ala Ala Val Thr Glu Thr Val Pro         115 120 125 Ile Leu Ser Ser Ser Leu Phe Thr Ile Ala Ala Thr Ile Ile Ala Leu     130 135 140 Phe Ser Leu Asp Trp Gln Phe Val Leu Ile Pro Val Val Val Ala Pro 145 150 155 160 Val Tyr Tyr Phe Ala Ser Lys His Tyr Leu Ser Lys Ala Pro Asp Arg                 165 170 175 Tyr Ala Ala Glu Arg Ala Ala Met Ala Glu Arg Ala Arg Lys Val Leu             180 185 190 Glu Ala Ile Arg Gly Arg Ala Thr Val Arg Ala Tyr Ser Met Glu Asp         195 200 205 Ala Met His Asn Gln Ile Asp Gln Ala Ser Trp Ser Val Val Val Lys     210 215 220 Gly Ile Arg Ala Arg Thr Thr Met Leu Ile Leu Asn Met Trp Met Leu 225 230 235 240 Phe Ala Glu Phe Leu Met Leu Ala Val Ala Leu Val Ile Gly Tyr Lys                 245 250 255 Leu Val Ile Asp Asn Ala Leu Thr Ile Gly Ala Val Thr Gly Ala Val             260 265 270 Leu Met Ile Ile Arg Leu Arg Gly Pro Met Asn Met Phe Met Arg Val         275 280 285 Leu Asp Thr Ile Gln Ser Gly Tyr Ala Ser Leu Ala Arg Ile Val Gly     290 295 300 Val Val Ala Asp Pro Pro Ile Pro Val Pro Asp Ser Gly Val Lys Ala 305 310 315 320 Pro Gln Gly Lys Val Glu Leu Arg Asn Val Ser Phe Ser Tyr Gly Asp                 325 330 335 Ser Trp Ala Val Lys Asp Ile Asp Ile Thr Ile Asn Ser Gly Glu Thr             340 345 350 Val Ala Leu Val Gly Ala Ser Gly Ala Gly Lys Thr Thr Val Ala Ala         355 360 365 Leu Leu Ala Gly Leu Arg Val Pro Asp Gln Gly Gln Val Leu Val Asp     370 375 380 Asp Phe Pro Val Ser His Leu Ser Asp Arg Glu Arg Ile Ala Arg Leu 385 390 395 400 Ala Met Val Ser Gln Glu Val His Val Phe Ser Gly Thr Leu Arg Gln                 405 410 415 Asp Leu Thr Leu Ala Lys Pro Asp Ala Ser Asp Glu Glu Leu Ala His             420 425 430 Ala Leu Gly Gln Val Asn Ala Leu Asp Trp Leu Glu Ser Leu Pro Glu         435 440 445 Gly Leu Asp Thr Val Val Gly Ala Arg Gly Ile Gln Leu Glu Pro Val     450 455 460 Val Ala Gln Gln Leu Ala Leu Ala Arg Val Leu Leu Leu Asn Pro Ala 465 470 475 480 Ile Val Ile Met Asp Glu Ala Thr Ala Glu Ala Gly Ser Ala Gly Ala                 485 490 495 Ser Ala Leu Glu Glu Ala Ala Asp Ala Val Ser Lys Asn Arg Ser Ala             500 505 510 Leu Val Val Ala His Arg Leu Asp Gln Ala Ser Arg Ala Asp Gln Ile         515 520 525 Leu Val Met Asp Lys Gly Glu Val Val Glu Ser Gly Thr His Gln Glu     530 535 540 Leu Leu Asp His Gly Gly Ile Tyr Gln Arg Leu Trp Thr Ala Trp Ser 545 550 555 560 Val Gly Arg <210> 291 <211> 1140 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1117) <223> RXN00243 <400> 291 cactgcgcca gatttttgat gccgacactg tggcaggtgt gcgcgctgag tacgaaaaat 60 ttaacaaagc agcccatgat ggaaatgaag aggaacagaa gtg acc agc gaa caa 115                                             Val Thr Ser Glu Gln                                               1 5 gct tta gat cct atc cac cca ggt cag ttc cgt ctt tct cgg att cag 163 Ala Leu Asp Pro Ile His Pro Gly Gln Phe Arg Leu Ser Arg Ile Gln                  10 15 20 ttg atc aac tgg gga acc ttc cac gga acg gtg gac att cct gtg acc 211 Leu Ile Asn Trp Gly Thr Phe His Gly Thr Val Asp Ile Pro Val Thr              25 30 35 agg gaa gga atc tta gtt acc ggt ggt tcg gga tca gga aaa tcc acg 259 Arg Glu Gly Ile Leu Val Thr Gly Gly Ser Gly Ser Gly Lys Ser Thr          40 45 50 ctg att gat gcg atc acg gcg gta ttg ctt ccg caa gga aag ctg agg 307 Leu Ile Asp Ala Ile Thr Ala Val Leu Leu Pro Gln Gly Lys Leu Arg      55 60 65 ttt aac tct gcc gca cag gct aat act ccg cgg aat aag gga cgc agt 355 Phe Asn Ser Ala Ala Gln Ala Asn Thr Pro Arg Asn Lys Gly Arg Ser  70 75 80 85 ttg gtt acc tat atc cgt ggc gct tgg cgt gcg cag gag gat ccg ctg 403 Leu Val Thr Tyr Ile Arg Gly Ala Trp Arg Ala Gln Glu Asp Pro Leu                  90 95 100 cag gat cag att gtc tcc acg tac cta cgt ccc cgc gca acc tat tcg 451 Gln Asp Gln Ile Val Ser Thr Tyr Leu Arg Pro Arg Ala Thr Tyr Ser             105 110 115 ctg gtt gga ttg act tat tcc aac ggt gaa ggc gtc gag cac acc ttg 499 Leu Val Gly Leu Thr Tyr Ser Asn Gly Glu Gly Val Glu His Thr Leu         120 125 130 gtg gct att ttc tat ctg aaa tcg gga cac aat tta acc tcc gat att 547 Val Ala Ile Phe Tyr Leu Lys Ser Gly His Asn Leu Thr Ser Asp Ile     135 140 145 tct tca tat tat ggt gtg ttt ccc gtt gat caa gac atc aat gcg ctg 595 Ser Ser Tyr Tyr Gly Val Phe Pro Val Asp Gln Asp Ile Asn Ala Leu 150 155 160 165 ctg gat ttc ctg aaa gag ggc atc gat aaa cgc cag atc aga gct gct 643 Leu Asp Phe Leu Lys Glu Gly Ile Asp Lys Arg Gln Ile Arg Ala Ala                 170 175 180 ttc aag gaa gcc atc ttt agc gag cag cat tct gta ttc tcc ggc agg 691 Phe Lys Glu Ala Ile Phe Ser Glu Gln His Ser Val Phe Ser Gly Arg             185 190 195 ttt aga agc cgt ttg ggg atc tcc agt gag gaa gct ttg ctg ttg ttg 739 Phe Arg Ser Arg Leu Gly Ile Ser Ser Glu Glu Ala Leu Leu Leu Leu         200 205 210 cac cgc gcg cag tcg gcg aaa gat ctt caa agc ttg gat gat cta ttt 787 His Arg Ala Gln Ser Ala Lys Asp Leu Gln Ser Leu Asp Asp Leu Phe     215 220 225 cgg gat tac atg ctg gtg gaa ccg gat acg ttc agc att gcc aaa act 835 Arg Asp Tyr Met Leu Val Glu Pro Asp Thr Phe Ser Ile Ala Lys Thr 230 235 240 245 gcc gtg gaa caa ttc caa gac ctt gaa ggt gct tat gag cag gtc gaa 883 Ala Val Glu Gln Phe Gln Asp Leu Glu Gly Ala Tyr Glu Gln Val Glu                 250 255 260 gat att aaa cgg cag atc cac acc ctg gat cct ttg gtg cag ctg aag 931 Asp Ile Lys Arg Gln Ile His Thr Leu Asp Pro Leu Val Gln Leu Lys             265 270 275 aat cgg cga gag aaa gcg caa cag tcc aaa gat cat gcc aat gca ctg 979 Asn Arg Arg Glu Lys Ala Gln Gln Ser Lys Asp His Ala Asn Ala Leu         280 285 290 aag aag gcg ctg ccg act gtc ggg aat cgc att aag aag gaa gag caa 1027 Lys Lys Ala Leu Pro Thr Val Gly Asn Arg Ile Lys Lys Glu Glu Gln     295 300 305 gaa ccg ctg gtt cga caa ttt act gtc gag caa acg cag cga agt cga 1075 Glu Pro Leu Val Arg Gln Phe Thr Val Glu Gln Thr Gln Arg Ser Arg 310 315 320 325 agg tgg agt ccg cca aaa ttg aga cag atc gtg ccc gcg aaa 1117 Arg Trp Ser Pro Pro Lys Leu Arg Gln Ile Val Pro Ala Lys                 330 335 tgaaaaccct cgcgcacgac aac 1140 <210> 292 <211> 339 <212> PRT <213> Corynebacterium glutamicum <400> 292 Val Thr Ser Glu Gln Ala Leu Asp Pro Ile His Pro Gly Gln Phe Arg   1 5 10 15 Leu Ser Arg Ile Gln Leu Ile Asn Trp Gly Thr Phe His Gly Thr Val              20 25 30 Asp Ile Pro Val Thr Arg Glu Gly Ile Leu Val Thr Gly Gly Ser Gly          35 40 45 Ser Gly Lys Ser Thr Leu Ile Asp Ala Ile Thr Ala Val Leu Leu Pro      50 55 60 Gln Gly Lys Leu Arg Phe Asn Ser Ala Ala Gln Ala Asn Thr Pro Arg  65 70 75 80 Asn Lys Gly Arg Ser Leu Val Thr Tyr Ile Arg Gly Ala Trp Arg Ala                  85 90 95 Gln Glu Asp Pro Leu Gln Asp Gln Ile Val Ser Thr Tyr Leu Arg Pro             100 105 110 Arg Ala Thr Tyr Ser Leu Val Gly Leu Thr Tyr Ser Asn Gly Glu Gly         115 120 125 Val Glu His Thr Leu Val Ala Ile Phe Tyr Leu Lys Ser Gly His Asn     130 135 140 Leu Thr Ser Asp Ile Ser Ser Tyr Tyr Gly Val Phe Pro Val Asp Gln 145 150 155 160 Asp Ile Asn Ala Leu Leu Asp Phe Leu Lys Glu Gly Ile Asp Lys Arg                 165 170 175 Gln Ile Arg Ala Ala Phe Lys Glu Ala Ile Phe Ser Glu Gln His Ser             180 185 190 Val Phe Ser Gly Arg Phe Arg Ser Arg Leu Gly Ile Ser Ser Glu Glu         195 200 205 Ala Leu Leu Leu Leu His Arg Ala Gln Ser Ala Lys Asp Leu Gln Ser     210 215 220 Leu Asp Asp Leu Phe Arg Asp Tyr Met Leu Val Glu Pro Asp Thr Phe 225 230 235 240 Ser Ile Ala Lys Thr Ala Val Glu Gln Phe Gln Asp Leu Glu Gly Ala                 245 250 255 Tyr Glu Gln Val Glu Asp Ile Lys Arg Gln Ile His Thr Leu Asp Pro             260 265 270 Leu Val Gln Leu Lys Asn Arg Arg Glu Lys Ala Gln Gln Ser Lys Asp         275 280 285 His Ala Asn Ala Leu Lys Lys Ala Leu Pro Thr Val Gly Asn Arg Ile     290 295 300 Lys Lys Glu Glu Gln Glu Pro Leu Val Arg Gln Phe Thr Val Glu Gln 305 310 315 320 Thr Gln Arg Ser Arg Arg Trp Ser Pro Pro Lys Leu Arg Gln Ile Val                 325 330 335 Pro Ala Lys <210> 293 <211> 1027 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (1027) <223> FRXA00243 <400> 293 cactgcgcca gatttttgat gccgacactg tggcaggtgt gcgcgctgag tacgaaaaat 60 ttaacaaagc agcccatgat ggaaatgaag aggaacagaa gtg acc agc gaa caa 115                                             Val Thr Ser Glu Gln                                               1 5 gct tta gat cct atc cac cca ggt cag ttc cgt ctt tct cgg att cag 163 Ala Leu Asp Pro Ile His Pro Gly Gln Phe Arg Leu Ser Arg Ile Gln                  10 15 20 ttg atc aac tgg gga acc ttc cac gga acg gtg gac att cct gtg acc 211 Leu Ile Asn Trp Gly Thr Phe His Gly Thr Val Asp Ile Pro Val Thr              25 30 35 agg gaa gga atc tta gtt acc ggt ggt tcg gga tca gga aaa tcc acg 259 Arg Glu Gly Ile Leu Val Thr Gly Gly Ser Gly Ser Gly Lys Ser Thr          40 45 50 ctg att gat gcg atc acg gcg gta ttg ctt ccg caa gga aag ctg agg 307 Leu Ile Asp Ala Ile Thr Ala Val Leu Leu Pro Gln Gly Lys Leu Arg      55 60 65 ttt aac tct gcc gca cag gct aat act ccg cgg aat aag gga cgc agt 355 Phe Asn Ser Ala Ala Gln Ala Asn Thr Pro Arg Asn Lys Gly Arg Ser  70 75 80 85 ttg gtt acc tat atc cgt ggc gct tgg cgt gcg cag gag gat ccg ctg 403 Leu Val Thr Tyr Ile Arg Gly Ala Trp Arg Ala Gln Glu Asp Pro Leu                  90 95 100 cag gat cag att gtc tcc acg tac cta cgt ccc cgc gca acc tat tcg 451 Gln Asp Gln Ile Val Ser Thr Tyr Leu Arg Pro Arg Ala Thr Tyr Ser             105 110 115 ctg gtt gga ttg act tat tcc aac ggt gaa ggc gtc gag cac acc ttg 499 Leu Val Gly Leu Thr Tyr Ser Asn Gly Glu Gly Val Glu His Thr Leu         120 125 130 gtg gct att ttc tat ctg aaa tcg gga cac aat tta acc tcc gat att 547 Val Ala Ile Phe Tyr Leu Lys Ser Gly His Asn Leu Thr Ser Asp Ile     135 140 145 tct tca tat tat ggt gtg ttt ccc gtt gat caa gac atc aat gcg ctg 595 Ser Ser Tyr Tyr Gly Val Phe Pro Val Asp Gln Asp Ile Asn Ala Leu 150 155 160 165 ctg gat ttc ctg aaa gag ggc atc gat aaa cgc cag atc aga gct gct 643 Leu Asp Phe Leu Lys Glu Gly Ile Asp Lys Arg Gln Ile Arg Ala Ala                 170 175 180 ttc aag gaa gcc atc ttt agc gag cag cat tct gta ttc tcc ggc agg 691 Phe Lys Glu Ala Ile Phe Ser Glu Gln His Ser Val Phe Ser Gly Arg             185 190 195 ttt aga agc cgt ttg ggg atc tcc agt gag gaa gct ttg ctg ttg ttg 739 Phe Arg Ser Arg Leu Gly Ile Ser Ser Glu Glu Ala Leu Leu Leu Leu         200 205 210 cac cgc gcg cag tcg gcg aaa gat ctt caa agc ttg gat gat cta ttt 787 His Arg Ala Gln Ser Ala Lys Asp Leu Gln Ser Leu Asp Asp Leu Phe     215 220 225 cgg gat tac atg ctg gtg gaa ccg gat acg ttc agc att gcc aaa act 835 Arg Asp Tyr Met Leu Val Glu Pro Asp Thr Phe Ser Ile Ala Lys Thr 230 235 240 245 gcc gtg gaa caa ttc caa gac ctt gaa ggt gct tat gag cag gtc gaa 883 Ala Val Glu Gln Phe Gln Asp Leu Glu Gly Ala Tyr Glu Gln Val Glu                 250 255 260 gat att aaa cgg cag atc cac acc ctg gat cct ttg gtg cag ctg aag 931 Asp Ile Lys Arg Gln Ile His Thr Leu Asp Pro Leu Val Gln Leu Lys             265 270 275 aat cgg cga gag aaa gcg caa cag tcc aaa gat cat gcc aat gca ctg 979 Asn Arg Arg Glu Lys Ala Gln Gln Ser Lys Asp His Ala Asn Ala Leu         280 285 290 aag aag gcg ctg ccg act gtc ggg aat cgc att aag aag gaa gag caa 1027 Lys Lys Ala Leu Pro Thr Val Gly Asn Arg Ile Lys Lys Glu Glu Gln     295 300 305 <210> 294 <211> 309 <212> PRT <213> Corynebacterium glutamicum <400> 294 Val Thr Ser Glu Gln Ala Leu Asp Pro Ile His Pro Gly Gln Phe Arg   1 5 10 15 Leu Ser Arg Ile Gln Leu Ile Asn Trp Gly Thr Phe His Gly Thr Val              20 25 30 Asp Ile Pro Val Thr Arg Glu Gly Ile Leu Val Thr Gly Gly Ser Gly          35 40 45 Ser Gly Lys Ser Thr Leu Ile Asp Ala Ile Thr Ala Val Leu Leu Pro      50 55 60 Gln Gly Lys Leu Arg Phe Asn Ser Ala Ala Gln Ala Asn Thr Pro Arg  65 70 75 80 Asn Lys Gly Arg Ser Leu Val Thr Tyr Ile Arg Gly Ala Trp Arg Ala                  85 90 95 Gln Glu Asp Pro Leu Gln Asp Gln Ile Val Ser Thr Tyr Leu Arg Pro             100 105 110 Arg Ala Thr Tyr Ser Leu Val Gly Leu Thr Tyr Ser Asn Gly Glu Gly         115 120 125 Val Glu His Thr Leu Val Ala Ile Phe Tyr Leu Lys Ser Gly His Asn     130 135 140 Leu Thr Ser Asp Ile Ser Ser Tyr Tyr Gly Val Phe Pro Val Asp Gln 145 150 155 160 Asp Ile Asn Ala Leu Leu Asp Phe Leu Lys Glu Gly Ile Asp Lys Arg                 165 170 175 Gln Ile Arg Ala Ala Phe Lys Glu Ala Ile Phe Ser Glu Gln His Ser             180 185 190 Val Phe Ser Gly Arg Phe Arg Ser Arg Leu Gly Ile Ser Ser Glu Glu         195 200 205 Ala Leu Leu Leu Leu His Arg Ala Gln Ser Ala Lys Asp Leu Gln Ser     210 215 220 Leu Asp Asp Leu Phe Arg Asp Tyr Met Leu Val Glu Pro Asp Thr Phe 225 230 235 240 Ser Ile Ala Lys Thr Ala Val Glu Gln Phe Gln Asp Leu Glu Gly Ala                 245 250 255 Tyr Glu Gln Val Glu Asp Ile Lys Arg Gln Ile His Thr Leu Asp Pro             260 265 270 Leu Val Gln Leu Lys Asn Arg Arg Glu Lys Ala Gln Gln Ser Lys Asp         275 280 285 His Ala Asn Ala Leu Lys Lys Ala Leu Pro Thr Val Gly Asn Arg Ile     290 295 300 Lys Lys Glu Glu Gln 305 <210> 295 <211> 2325 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (2302) <223> RXA00259 <400> 295 ggccttatta acatacggcg gttctagcac acagcgatgg atgatgtgtc ccaccgatat 60 tgctgcatgt gccaagattt agcacggtac agtgctagaa atg agc gga ctg ttt 115                                             Met Ser Gly Leu Phe                                               1 5 acc cca ttt tca gat gcg gca aaa aac aac acg gta aaa act gat gga 163 Thr Pro Phe Ser Asp Ala Ala Lys Asn Asn Thr Val Lys Thr Asp Gly                  10 15 20 gat tca gta tct ggt cga gac ttg cct att act aag atc tct gag gat 211 Asp Ser Val Ser Gly Arg Asp Leu Pro Ile Thr Lys Ile Ser Glu Asp              25 30 35 cgt ttc gag cgt tct gcg tat tca gcc cag ctg gca aat ata atc tgc 259 Arg Phe Glu Arg Ser Ala Tyr Ser Ala Gln Leu Ala Asn Ile Cys          40 45 50 gat gtg gca cct tgg gga gcg agc act gtt ttc agt ctt act ggt cag 307 Asp Val Ala Pro Trp Gly Ala Ser Thr Val Phe Ser Leu Thr Gly Gln      55 60 65 tgg ggc agt ggt aag aca tct ctt gtt aat ttg att cgc tcg gaa gaa 355 Trp Gly Ser Gly Lys Thr Ser Leu Val Asn Leu Ile Arg Ser Glu Glu  70 75 80 85 tct cta tcg aac gaa aaa tgg aca atc gtt gat ttc aac ccg tgg gtg 403 Ser Leu Ser Asn Glu Lys Trp Thr Ile Val Asp Phe Asn Pro Trp Val                  90 95 100 gcc tct gac ccg caa tct ttg att gag gag ttt tac cga gta atc gtt 451 Ala Ser Asp Pro Gln Ser Leu Ile Glu Glu Phe Tyr Arg Val Ile Val             105 110 115 ggg acg gta cct gat gat aag acc ggc caa aag atc aaa act gtt ctg 499 Gly Thr Val Pro Asp Asp Lys Thr Gly Gln Lys Ile Lys Thr Val Leu         120 125 130 cag aaa acc ttt agc acg att ggg tca att gca ggt ggg gtc gga ggg 547 Gln Lys Thr Phe Ser Thr Ile Gly Ser Ile Ala Gly Gly Val Gly Gly     135 140 145 ttt ggt gtc cta gaa gca ctt gcg ctc tca aaa gga gta gat gct gca 595 Phe Gly Val Leu Glu Ala Leu Ala Leu Ser Lys Gly Val Asp Ala Ala 150 155 160 165 aac gct gta tat aag aca tgg aaa cag gag caa gat tcg tgg cca acg 643 Asn Ala Val Tyr Lys Thr Trp Lys Gln Glu Gln Asp Ser Trp Pro Thr                 170 175 180 ctg tat aca cgt gct gcg aac cat ttt aaa gat ctg aac aag cga att 691 Leu Tyr Thr Arg Ala Ala Asn His Phe Lys Asp Leu Asn Lys Arg Ile             185 190 195 ctc att gtc gtc gat gat att gat cgc ctc cat act gat gaa ttg gcg 739 Leu Ile Val Val Asp Asp Ile Asp Arg Leu His Thr Asp Glu Leu Ala         200 205 210 ctg tta atg aaa gta ata cgc ttg ctt gga cga ttc ccg cag gtg aat 787 Leu Leu Met Lys Val Ile Arg Leu Leu Gly Arg Phe Pro Gln Val Asn     215 220 225 tat ctt ttg gtt tat gaa gaa gaa tca ctg tta acg acg cta gcc aga 835 Tyr Leu Leu Val Tyr Glu Glu Glu Ser Leu Leu Thr Thr Leu Ala Arg 230 235 240 245 tcg aca gct gta ggt ggt agc gaa gat gat gct ttg cgt ttc atg gag 883 Ser Thr Ala Val Gly Gly Ser Glu Asp Asp Ala Leu Arg Phe Met Glu                 250 255 260 aaa atc gtg cag tat cct ttc gat gtt ccg cct ctg aca tca ttt caa 931 Lys Ile Val Gln Tyr Pro Phe Asp Val Pro Pro Leu Thr Ser Phe Gln             265 270 275 ata gag aaa gag ctc agt gca tta ttt gac aag ctt ttc cag ggt gtt 979 Ile Glu Lys Glu Leu Ser Ala Leu Phe Asp Lys Leu Phe Gln Gly Val         280 285 290 tcg cta tcg ggt gat cct gaa gac ttt gca cta gtg aag tcg aga atg 1027 Ser Leu Ser Gly Asp Pro Glu Asp Phe Ala Leu Val Lys Ser Arg Met     295 300 305 ttc gat gtc tgg gaa aag act ctg gtc acg ccg agg ctg ttg cac cgt 1075 Phe Asp Val Trp Glu Lys Thr Leu Val Thr Pro Arg Leu Leu His Arg 310 315 320 325 ttt gct gct cta cta acc aac tgg act cgg ata tat gga tca ggt gaa 1123 Phe Ala Ala Leu Leu Thr Asn Trp Thr Arg Ile Tyr Gly Ser Gly Glu                 330 335 340 gtt aac ggc gtt gat ctc aca ata ctt gcg acc att cga att gtt ttt 1171 Val Asn Gly Val Asp Leu Thr Ile Leu Ala Thr Ile Arg Ile Val Phe             345 350 355 ccg tct gtg tat aaa cgt ctt tct cga gcg aag gaa gta ttg ctt caa 1219 Pro Ser Val Tyr Lys Arg Leu Ser Arg Ala Lys Glu Val Leu Leu Gln         360 365 370 gga ggt cga acg aca ggc tcg cag aaa ccc ggt tgg gaa aag caa tta 1267 Gly Gly Arg Thr Thr Gly Ser Gln Lys Pro Gly Trp Glu Lys Gln Leu     375 380 385 tgt gag ggg atg aac aac gag cag atg gat ctt tta aag acc atg ctt 1315 Cys Glu Gly Met Asn Asn Glu Gln Met Asp Leu Leu Lys Thr Met Leu 390 395 400 405 ttg ttc ctt ttc cca cgt ctt tcg gat cac cct agt acg aga atg cat 1363 Leu Phe Leu Phe Pro Arg Leu Ser Asp His Pro Ser Thr Arg Met His                 410 415 420 cgt gag agg ggg atc tcg acg gaa gtt tat ttt gac acg tac ctc atg 1411 Arg Glu Arg Gly Ile Ser Thr Glu Val Tyr Phe Asp Thr Tyr Leu Met             425 430 435 ttt caa aga cct gga cat gtc ata agt gat gaa cag ttg gat aag tat 1459 Phe Gln Arg Pro Gly His Val Ile Ser Asp Glu Gln Leu Asp Lys Tyr         440 445 450 cta tct aat gcg gac gat gct atg ggt ttc gtc gat tta att aac tcc 1507 Leu Ser Asn Ala Asp Asp Ala Met Gly Phe Val Asp Leu Ile Asn Ser     455 460 465 gat gac aat gac atg gtg gca tca gtg atg aaa aag ctt cct cta gca 1555 Asp Asp Asn Asp Met Val Ala Ser Val Met Lys Lys Leu Pro Leu Ala 470 475 480 485 att gat cga ctt gat gga gag ggt gtt agg cac atg gca gtt gag gtg 1603 Ile Asp Arg Leu Asp Gly Glu Gly Val Arg His Met Ala Val Glu Val                 490 495 500 tta ttc acc gct gct aat ggt atg cat gat aaa ggt cgt caa gtg cgt 1651 Leu Phe Thr Ala Ala Asn Gly Met His Asp Lys Gly Arg Gln Val Arg             505 510 515 atg agc ggc ata ttc agt gac ctg tat tcc cat gcg tgc tcg att ctt 1699 Met Ser Gly Ile Phe Ser Asp Leu Tyr Ser His Ala Cys Ser Ile Leu         520 525 530 ggt gca ttg cct caa tta cca gtg gaa caa ctc tat gag aaa ttc ttt 1747 Gly Ala Leu Pro Gln Leu Pro Val Glu Gln Leu Tyr Glu Lys Phe Phe     535 540 545 tct gag atg acg ctt aat gag gct gct ttc tgg tta aac cag gtg ggg 1795 Ser Glu Met Thr Leu Asn Glu Ala Ala Phe Trp Leu Asn Gln Val Gly 550 555 560 565 gaa agg gct aga gcc tgt ggt aat gat gta agt ggc ctt gag ctt ttt 1843 Glu Arg Ala Arg Ala Cys Gly Asn Asp Val Ser Gly Leu Glu Leu Phe                 570 575 580 cgt aaa gtt aat ata aag acc gaa gct aga att tta agt gta ttg aag 1891 Arg Lys Val Asn Ile Lys Thr Glu Ala Arg Ile Leu Ser Val Leu Lys             585 590 595 aat cag gac ccc tca gat tgg gat tta ggt cca tat tcg ctt ggt att 1939 Asn Gln Asp Pro Ser Asp Trp Asp Leu Gly Pro Tyr Ser Leu Gly Ile         600 605 610 ttg gcg aaa agc tcg aat ttt tct tca gtg ctg aag tct ctg caa agt 1987 Leu Ala Lys Ser Ser Asn Phe Ser Ser Val Leu Lys Ser Leu Gln Ser     615 620 625 ggt ata gag gaa cat cag ttt gat gtg ata gat att gga gtg ctt ttc 2035 Gly Ile Glu Glu His Gln Phe Asp Val Ile Asp Ile Gly Val Leu Phe 630 635 640 645 tta acg act gtg tat tct tcg cga cag gga cca agc ggt ggt gca tgg 2083 Leu Thr Thr Val Tyr Ser Ser Arg Gln Gly Pro Ser Gly Gly Ala Trp                 650 655 660 ata gat tct ttt cag cat agt ctg ttt tca cgg tac gta cct gat tct 2131 Ile Asp Ser Phe Gln His Ser Leu Phe Ser Arg Tyr Val Pro Asp Ser             665 670 675 cta cgg gct ata acc aag tct gaa gta gat gta gaa cta ggt aag ata 2179 Leu Arg Ala Ile Thr Lys Ser Glu Val Asp Val Glu Leu Gly Lys Ile         680 685 690 cag ttc acg gat ttt agc tgg gaa ggg aag cga aaa gtt gtc gca tat 2227 Gln Phe Thr Asp Phe Ser Trp Glu Gly Lys Arg Lys Val Val Ala Tyr     695 700 705 gca ctg gag act gga aga agt gat ttc act cga gaa cga tta ggg ggc 2275 Ala Leu Glu Thr Gly Arg Ser Asp Phe Thr Arg Glu Arg Leu Gly Gly 710 715 720 725 tac agt atc gca gat tct ata gtc gat tgatgaggct gaggtcatga 2322 Tyr Ser Ile Ala Asp Ser Ile Val Asp                 730 ctt 2325 <210> 296 <211> 734 <212> PRT <213> Corynebacterium glutamicum <400> 296 Met Ser Gly Leu Phe Thr Pro Phe Ser Asp Ala Ala Lys Asn Asn Thr   1 5 10 15 Val Lys Thr Asp Gly Asp Ser Val Ser Gly Arg Asp Leu Pro Ile Thr              20 25 30 Lys Ile Ser Glu Asp Arg Phe Glu Arg Ser Ala Tyr Ser Ala Gln Leu          35 40 45 Ala Asn Ile Ile Cys Asp Val Ala Pro Trp Gly Ala Ser Thr Val Phe      50 55 60 Ser Leu Thr Gly Gln Trp Gly Ser Gly Lys Thr Ser Leu Val Asn Leu  65 70 75 80 Ile Arg Ser Glu Glu Ser Leu Ser Asn Glu Lys Trp Thr Ile Val Asp                  85 90 95 Phe Asn Pro Trp Val Ala Ser Asp Pro Gln Ser Leu Ile Glu Glu Phe             100 105 110 Tyr Arg Val Ile Val Gly Thr Val Pro Asp Asp Lys Thr Gly Gln Lys         115 120 125 Ile Lys Thr Val Leu Gln Lys Thr Phe Ser Thr Ile Gly Ser Ile Ala     130 135 140 Gly Gly Val Gly Gly Phe Gly Val Leu Glu Ala Leu Ala Leu Ser Lys 145 150 155 160 Gly Val Asp Ala Ala Asn Ala Val Tyr Lys Thr Trp Lys Gln Glu Gln                 165 170 175 Asp Ser Trp Pro Thr Leu Tyr Thr Arg Ala Ala Asn His Phe Lys Asp             180 185 190 Leu Asn Lys Arg Ile Leu Ile Val Val Asp Asp Ile Asp Arg Leu His         195 200 205 Thr Asp Glu Leu Ala Leu Leu Met Lys Val Ile Arg Leu Leu Gly Arg     210 215 220 Phe Pro Gln Val Asn Tyr Leu Leu Val Tyr Glu Glu Glu Ser Leu Leu 225 230 235 240 Thr Thr Leu Ala Arg Ser Thr Ala Val Gly Gly Ser Glu Asp Asp Ala                 245 250 255 Leu Arg Phe Met Glu Lys Ile Val Gln Tyr Pro Phe Asp Val Pro Pro             260 265 270 Leu Thr Ser Phe Gln Ile Glu Lys Glu Leu Ser Ala Leu Phe Asp Lys         275 280 285 Leu Phe Gln Gly Val Ser Leu Ser Gly Asp Pro Glu Asp Phe Ala Leu     290 295 300 Val Lys Ser Arg Met Phe Asp Val Trp Glu Lys Thr Leu Val Thr Pro 305 310 315 320 Arg Leu Leu His Arg Phe Ala Ala Leu Leu Thr Asn Trp Thr Arg Ile                 325 330 335 Tyr Gly Ser Gly Glu Val Asn Gly Val Asp Leu Thr Ile Leu Ala Thr             340 345 350 Ile Arg Ile Val Phe Pro Ser Val Tyr Lys Arg Leu Ser Arg Ala Lys         355 360 365 Glu Val Leu Leu Gln Gly Gly Arg Thr Thr Gly Ser Gln Lys Pro Gly     370 375 380 Trp Glu Lys Gln Leu Cys Glu Gly Met Asn Asn Glu Gln Met Asp Leu 385 390 395 400 Leu Lys Thr Met Leu Leu Phe Leu Phe Pro Arg Leu Ser Asp His Pro                 405 410 415 Ser Thr Arg Met His Arg Glu Arg Gly Ile Ser Thr Glu Val Tyr Phe             420 425 430 Asp Thr Tyr Leu Met Phe Gln Arg Pro Gly His Val Ile Ser Asp Glu         435 440 445 Gln Leu Asp Lys Tyr Leu Ser Asn Ala Asp Asp Ala Met Gly Phe Val     450 455 460 Asp Leu Ile Asn Ser Asp Asp Asn Asp Met Val Ala Ser Val Met Lys 465 470 475 480 Lys Leu Pro Leu Ala Ile Asp Arg Leu Asp Gly Glu Gly Val Arg His                 485 490 495 Met Ala Val Glu Val Leu Phe Thr Ala Ala Asn Gly Met His Asp Lys             500 505 510 Gly Arg Gln Val Arg Met Ser Gly Ile Phe Ser Asp Leu Tyr Ser His         515 520 525 Ala Cys Ser Ile Leu Gly Ala Leu Pro Gln Leu Pro Val Glu Gln Leu     530 535 540 Tyr Glu Lys Phe Phe Ser Glu Met Thr Leu Asn Glu Ala Ala Phe Trp 545 550 555 560 Leu Asn Gln Val Gly Glu Arg Ala Arg Ala Cys Gly Asn Asp Val Ser                 565 570 575 Gly Leu Glu Leu Phe Arg Lys Val Asn Ile Lys Thr Glu Ala Arg Ile             580 585 590 Leu Ser Val Leu Lys Asn Gln Asp Pro Ser Asp Trp Asp Leu Gly Pro         595 600 605 Tyr Ser Leu Gly Ile Leu Ala Lys Ser Ser Asn Phe Ser Ser Val Leu     610 615 620 Lys Ser Leu Gln Ser Gly Ile Glu Glu His Gln Phe Asp Val Ile Asp 625 630 635 640 Ile Gly Val Leu Phe Leu Thr Thr Val Tyr Ser Ser Arg Gln Gly Pro                 645 650 655 Ser Gly Gly Ala Trp Ile Asp Ser Phe Gln His Ser Leu Phe Ser Arg             660 665 670 Tyr Val Pro Asp Ser Leu Arg Ala Ile Thr Lys Ser Glu Val Asp Val         675 680 685 Glu Leu Gly Lys Ile Gln Phe Thr Asp Phe Ser Trp Glu Gly Lys Arg     690 695 700 Lys Val Val Ala Tyr Ala Leu Glu Thr Gly Arg Ser Asp Phe Thr Arg 705 710 715 720 Glu Arg Leu Gly Gly Tyr Ser Ile Ala Asp Ser Ile Val Asp                 725 730 <210> 297 <211> 789 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (766) <223> RXN00410 <400> 297 gtgttgatgc gttagtccac ccacgcagct acgccccaaa ggaataatct tgaaccctgc 60 cacagataac gctccgccgg tcctttcagc ccaagatctc atg atg atc tat gga 115                                             Met Met Ile Tyr Gly                                               1 5 aaa gga tca aca gaa gtt cgg gct ctc gat ggc att tct gta cag att 163 Lys Gly Ser Thr Glu Val Arg Ala Leu Asp Gly Ile Ser Val Gln Ile                  10 15 20 cag tcc gac aaa tgg acc tcc atc atg ggg caa tca ggc tct ggc aaa 211 Gln Ser Asp Lys Trp Thr Ser Ile Met Gly Gln Ser Gly Ser Gly Lys              25 30 35 aca act ctg ttg cag tgc ctt tcc gga ttg gcg cag cca acc tca ggc 259 Thr Thr Leu Leu Gln Cys Leu Ser Gly Leu Ala Gln Pro Thr Ser Gly          40 45 50 aga gtg aca ctg aac aaa aac aac atc acg ttg agc tcc ctg tca gaa 307 Arg Val Thr Leu Asn Lys Asn Asn Ile Thr Leu Ser Ser Leu Ser Glu      55 60 65 aat aag cgt gcc aag ctg cgt cgc acg cac atc agc atg gtg ttt cag 355 Asn Lys Arg Ala Lys Leu Arg Arg Thr His Ile Ser Met Val Phe Gln  70 75 80 85 gat ttc aac ttg gtg cct att ttg tcg gtg aag gac aat att ttg ctg 403 Asp Phe Asn Leu Val Pro Ile Leu Ser Val Lys Asp Asn Ile Leu Leu                  90 95 100 ccg ttg cgt ctt gcg cat cgc agg gtg gat aag cag tgg ttt gaa cac 451 Pro Leu Arg Leu Ala His Arg Arg Val Asp Lys Gln Trp Phe Glu His             105 110 115 atc acc agt gtg ttg aag att gat aat cgt atg cgc cat ttg cct ggg 499 Ile Thr Ser Val Leu Lys Ile Asp Asn Arg Met Arg His Leu Pro Gly         120 125 130 gag ctg tct ggc ggt cag caa caa cgc gcc gcg att gcc cgg gcg ttg 547 Glu Leu Ser Gly Gly Gln Gln Gln Arg Ala Ala Ile Ala Arg Ala Leu     135 140 145 atg tct agg ccc gat att gtc att gcg gat gag cca aca gga agt ttg 595 Met Ser Arg Pro Asp Ile Val Ile Ala Asp Glu Pro Thr Gly Ser Leu 150 155 160 165 gat tcc gtc acc agc gat gca gtg ttg aat ttg ttc cgc agc att gtt 643 Asp Ser Val Thr Ser Asp Ala Val Leu Asn Leu Phe Arg Ser Ile Val                 170 175 180 gat gat ttt ggg cag tca ctt gtg ttt gtc acc cac gat aaa gat gct 691 Asp Asp Phe Gly Gln Ser Leu Val Phe Val Thr His Asp Lys Asp Ala             185 190 195 gct cac cgt ggt gac gtg ttg atc aca atg cgt gat ggc aag atc atc 739 Ala His Arg Gly Asp Val Leu Ile Thr Met Arg Asp Gly Lys Ile Ile         200 205 210 gat acg gca gat ttg cgg gtg ggg cgt taatgttcag gcttgctttc 786 Asp Thr Ala Asp Leu Arg Val Gly Arg     215 220 gct 789 <210> 298 <211> 222 <212> PRT <213> Corynebacterium glutamicum <400> 298 Met Met Ile Tyr Gly Lys Gly Ser Thr Glu Val Arg Ala Leu Asp Gly   1 5 10 15 Ile Ser Val Gln Ile Gln Ser Asp Lys Trp Thr Ser Ile Met Gly Gln              20 25 30 Ser Gly Ser Gly Lys Thr Thr Leu Leu Gln Cys Leu Ser Gly Leu Ala          35 40 45 Gln Pro Thr Ser Gly Arg Val Thr Leu Asn Lys Asn Asn Ile Thr Leu      50 55 60 Ser Ser Leu Ser Glu Asn Lys Arg Ala Lys Leu Arg Arg Thr His Ile  65 70 75 80 Ser Met Val Phe Gln Asp Phe Asn Leu Val Pro Ile Leu Ser Val Lys                  85 90 95 Asp Asn Ile Leu Leu Pro Leu Arg Leu Ala His Arg Arg Val Asp Lys             100 105 110 Gln Trp Phe Glu His Ile Thr Ser Val Leu Lys Ile Asp Asn Arg Met         115 120 125 Arg His Leu Pro Gly Glu Leu Ser Gly Gly Gln Gln Gln Arg Ala Ala     130 135 140 Ile Ala Arg Ala Leu Met Ser Arg Pro Asp Ile Val Ile Ala Asp Glu 145 150 155 160 Pro Thr Gly Ser Leu Asp Ser Val Thr Ser Asp Ala Val Leu Asn Leu                 165 170 175 Phe Arg Ser Ile Val Asp Asp Phe Gly Gln Ser Leu Val Phe Val Thr             180 185 190 His Asp Lys Asp Ala Ala His Arg Gly Asp Val Leu Ile Thr Met Arg         195 200 205 Asp Gly Lys Ile Ile Asp Thr Ala Asp Leu Arg Val Gly Arg     210 215 220 <210> 299 <211> 789 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (766) <223> FRXA00410 <400> 299 gtgttgatgc gttagtccac ccacgcagct acgccccaaa ggaataatct tgaaccctgc 60 cacagataac gctccgccgg tcctttcagc ccaagatctc atg atg atc tat gga 115                                             Met Met Ile Tyr Gly                                               1 5 aaa gga tca aca gaa gtt cgg gct ctc gat ggc att tct gta cag att 163 Lys Gly Ser Thr Glu Val Arg Ala Leu Asp Gly Ile Ser Val Gln Ile                  10 15 20 cag tcc gac aaa tgg acc tcc atc atg ggg caa tca ggc tct ggc aaa 211 Gln Ser Asp Lys Trp Thr Ser Ile Met Gly Gln Ser Gly Ser Gly Lys              25 30 35 aca act ctg ttg cag tgc ctt tcc gga ttg gcg cag cca acc tca ggc 259 Thr Thr Leu Leu Gln Cys Leu Ser Gly Leu Ala Gln Pro Thr Ser Gly          40 45 50 aga gtg aca ctg aac aaa aac aac atc acg ttg agc tcc ctg tca gaa 307 Arg Val Thr Leu Asn Lys Asn Asn Ile Thr Leu Ser Ser Leu Ser Glu      55 60 65 aat aag cgt gcc aag ctg cgt cgc acg cac atc agc atg gtg ttt cag 355 Asn Lys Arg Ala Lys Leu Arg Arg Thr His Ile Ser Met Val Phe Gln  70 75 80 85 gat ttc aac ttg gtg cct att ttg tcg gtg aag gac aat att ttg ctg 403 Asp Phe Asn Leu Val Pro Ile Leu Ser Val Lys Asp Asn Ile Leu Leu                  90 95 100 ccg ttg cgt ctt gcg cat cgc agg gtg gat aag cag tgg ttt gaa cac 451 Pro Leu Arg Leu Ala His Arg Arg Val Asp Lys Gln Trp Phe Glu His             105 110 115 atc acc agt gtg ttg aag att gat aat cgt atg cgc cat ttg cct ggg 499 Ile Thr Ser Val Leu Lys Ile Asp Asn Arg Met Arg His Leu Pro Gly         120 125 130 gag ctg tct ggc ggt cag caa caa cgc gcc gcg att gcc cgg gcg ttg 547 Glu Leu Ser Gly Gly Gln Gln Gln Arg Ala Ala Ile Ala Arg Ala Leu     135 140 145 atg tct agg ccc gat att gtc att gcg gat gag cca aca gga agt ttg 595 Met Ser Arg Pro Asp Ile Val Ile Ala Asp Glu Pro Thr Gly Ser Leu 150 155 160 165 gat tcc gtc acc agc gat gca gtg ttg aat ttg ttc cgc agc att gtt 643 Asp Ser Val Thr Ser Asp Ala Val Leu Asn Leu Phe Arg Ser Ile Val                 170 175 180 gat gat ttt ggg cag tca ctt gtg ttt gtc acc cac gat aaa gat gct 691 Asp Asp Phe Gly Gln Ser Leu Val Phe Val Thr His Asp Lys Asp Ala             185 190 195 gct cac cgt ggt gac gtg ttg atc aca atg cgt gat ggc aag atc atc 739 Ala His Arg Gly Asp Val Leu Ile Thr Met Arg Asp Gly Lys Ile Ile         200 205 210 gat acg gca gat ttg cgg gtg ggg cgt taatgttcag gcttgctttc 786 Asp Thr Ala Asp Leu Arg Val Gly Arg     215 220 gct 789 <210> 300 <211> 222 <212> PRT <213> Corynebacterium glutamicum <400> 300 Met Met Ile Tyr Gly Lys Gly Ser Thr Glu Val Arg Ala Leu Asp Gly   1 5 10 15 Ile Ser Val Gln Ile Gln Ser Asp Lys Trp Thr Ser Ile Met Gly Gln              20 25 30 Ser Gly Ser Gly Lys Thr Thr Leu Leu Gln Cys Leu Ser Gly Leu Ala          35 40 45 Gln Pro Thr Ser Gly Arg Val Thr Leu Asn Lys Asn Asn Ile Thr Leu      50 55 60 Ser Ser Leu Ser Glu Asn Lys Arg Ala Lys Leu Arg Arg Thr His Ile  65 70 75 80 Ser Met Val Phe Gln Asp Phe Asn Leu Val Pro Ile Leu Ser Val Lys                  85 90 95 Asp Asn Ile Leu Leu Pro Leu Arg Leu Ala His Arg Arg Val Asp Lys             100 105 110 Gln Trp Phe Glu His Ile Thr Ser Val Leu Lys Ile Asp Asn Arg Met         115 120 125 Arg His Leu Pro Gly Glu Leu Ser Gly Gly Gln Gln Gln Arg Ala Ala     130 135 140 Ile Ala Arg Ala Leu Met Ser Arg Pro Asp Ile Val Ile Ala Asp Glu 145 150 155 160 Pro Thr Gly Ser Leu Asp Ser Val Thr Ser Asp Ala Val Leu Asn Leu                 165 170 175 Phe Arg Ser Ile Val Asp Asp Phe Gly Gln Ser Leu Val Phe Val Thr             180 185 190 His Asp Lys Asp Ala Ala His Arg Gly Asp Val Leu Ile Thr Met Arg         195 200 205 Asp Gly Lys Ile Ile Asp Thr Ala Asp Leu Arg Val Gly Arg     210 215 220 <210> 301 <211> 1500 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (1477) <223> RXN00456 <400> 301 ctcaccaacc cggagatcgt cacagcggtg ctaacggatc atgcctagct tatggcgtgc 60 tcgtcgcaga cttttgctca ttgccctagg tgtacttggt gtg ctg cag gca ctg 115                                             Val Leu Gln Ala Leu                                               1 5 ctg gcg atc atg gtg tcg ttg agc gta gcc gcc ata ctt gag gga aac 163 Leu Ala Ile Met Val Ser Leu Ser Val Ala Ala Ile Leu Glu Gly Asn                  10 15 20 cga gca ctt gtt gga ttg ctg ctt gct acc acg ttg ggt ttg ggg gtg 211 Arg Ala Leu Val Gly Leu Leu Leu Ala Thr Thr Leu Gly Leu Gly Val              25 30 35 gcg cag tgg att caa aaa gta gtg gca gaa gat cta ggc cag cat tat 259 Ala Gln Trp Ile Gln Lys Val Val Ala Glu Asp Leu Gly Gln His Tyr          40 45 50 gtg cat gag gtg cgt cgt gaa ttg gtg ggt gct gcg ctg gtg cct gga 307 Val His Glu Val Arg Arg Glu Leu Val Gly Ala Ala Leu Val Pro Gly      55 60 65 aat acg gcc tcg ttg ggc gtg act gtc acc cga gcc agc aat gat ctc 355 Asn Thr Ala Ser Leu Gly Val Thr Val Thr Arg Ala Ser Asn Asp Leu  70 75 80 85 acc gcg gtg cgc aat tgg gtg gct ttg ggc att gtt ccg atg gtc acc 403 Thr Ala Val Arg Asn Trp Val Ala Leu Gly Ile Val Pro Met Val Thr                  90 95 100 ggg ctg ccg ttg att gcg att gtg ctg gtg gcg ttg ttt atc caa gat 451 Gly Leu Pro Leu Ile Ala Ile Val Leu Val Ala Leu Phe Ile Gln Asp             105 110 115 ctc cgc aca ggc gtg gct gtt act gtg cca ctg ctc atg tgt gta gcc 499 Leu Arg Thr Gly Val Ala Val Thr Val Pro Leu Leu Met Cys Val Ala         120 125 130 gtg ctg ccg gtg gtg gcg cgg tgg act ttg aaa aga gca cgt gaa cta 547 Val Leu Pro Val Val Ala Arg Trp Thr Leu Lys Arg Ala Arg Glu Leu     135 140 145 cgc aaa aaa cgt gga cgc atg gct gcg cgg atc gca gat tct gtc atg 595 Arg Lys Lys Arg Gly Arg Met Ala Ala Arg Ile Ala Asp Ser Val Met 150 155 160 165 gct gga gaa tta ctg cac gca aca gga gca ata gac cgt gag ctc aat 643 Ala Gly Glu Leu Leu His Ala Thr Gly Ala Ile Asp Arg Glu Leu Asn                 170 175 180 gca gtc acc cga gat tcc gac cga gtg gtg ata gct gct gta aga cgt 691 Ala Val Thr Arg Asp Ser Asp Arg Val Val Ile Ala Ala Val Arg Arg             185 190 195 tcc tgg gcc acc ggt ttt agc cgc gca ttg atg gcc atg gca gcc tcg 739 Ser Trp Ala Thr Gly Phe Ser Arg Ala Leu Met Ala Met Ala Ala Ser         200 205 210 ctt ggc act gtc agc att gtg att tct ggc cac ctg gaa gta agt gag 787 Leu Gly Thr Val Ser Ile Val Ile Ser Gly His Leu Glu Val Ser Glu     215 220 225 gtt gcg gga ata atg atg ctt ctt ggc gtt ctt gcc act cca gtt gca 835 Val Ala Gly Ile Met Met Leu Leu Gly Val Leu Ala Thr Pro Val Ala 230 235 240 245 gaa ctt ggc cgc gtg gtg gaa tat cgc caa aat tat aaa gcc gcg aca 883 Glu Leu Gly Arg Val Val Glu Tyr Arg Gln Asn Tyr Lys Ala Ala Thr                 250 255 260 cgc atc ctg att cca ctt ctg caa cga ggc tca gaa ttt aaa cac tcc 931 Arg Ile Leu Ile Pro Leu Leu Gln Arg Gly Ser Glu Phe Lys His Ser             265 270 275 caa caa aaa cta ccc ggg ttg caa gca aca gaa gga atc ccc ggt gtc 979 Gln Gln Lys Leu Pro Gly Leu Gln Ala Thr Glu Gly Ile Pro Gly Val         280 285 290 tat gtc aaa ggt att tcc gcc ctt cct gga gaa cgg atc tac ctc cac 1027 Tyr Val Lys Gly Ile Ser Ala Leu Pro Gly Glu Arg Ile Tyr Leu His     295 300 305 ggc tct gca gat gcg acg aga aaa tgg gtc acc tcg ttg tct gca atg 1075 Gly Ser Ala Asp Ala Thr Arg Lys Trp Val Thr Ser Leu Ser Ala Met 310 315 320 325 gag gaa ggc aca gat gta ata gtc aac ggt caa agg ctt tcg cag ctt 1123 Glu Glu Gly Thr Asp Val Ile Val Asn Gly Gln Arg Leu Ser Gln Leu                 330 335 340 cct ttg aaa caa cga cgc gcc ctc atc gga atc gcc tca gca cac cac 1171 Pro Leu Lys Gln Arg Arg Ala Leu Ile Gly Ile Ala Ser Ala His His             345 350 355 cac tta agc cgt ggt tca gta tcg cgc ctg gtt ggt ttg cga gtg ccg 1219 His Leu Ser Arg Gly Ser Val Ser Arg Leu Val Gly Leu Arg Val Pro         360 365 370 gat gcc acc gtg gaa gaa att gag caa gca ctg gaa caa gtt ggt ctg 1267 Asp Ala Thr Val Glu Glu Ile Glu Gln Ala Leu Glu Gln Val Gly Leu     375 380 385 aac aac acc ggg aaa caa cgc ttg aaa aac ggc gga cac ccc tgg agt 1315 Asn Asn Thr Gly Lys Gln Arg Leu Lys Asn Gly Gly His Pro Trp Ser 390 395 400 405 act tcg cag atc aac aaa ctg aaa att gcc agc gcc acc ctt cga acc 1363 Thr Ser Gln Ile Asn Lys Leu Lys Ile Ala Ser Ala Thr Leu Arg Thr                 410 415 420 cca ccg ctt ttg gta ctt gaa ggc atc acc cct gaa aac ctc ctc aac 1411 Pro Pro Leu Leu Val Leu Glu Gly Ile Thr Pro Glu Asn Leu Leu Asn             425 430 435 tat ccc gga gtg atc atc tcc acc gtt cag gag aac cca tcc gaa aca 1459 Tyr Pro Gly Val Ile Ile Ser Thr Val Gln Glu Asn Pro Ser Glu Thr         440 445 450 tgg cgg caa gtg aac atc taatctagaa acatggcagg acg 1500 Trp Arg Gln Val Asn Ile     455 <210> 302 <211> 459 <212> PRT <213> Corynebacterium glutamicum <400> 302 Val Leu Gln Ala Leu Leu Ala Ile Met Val Ser Leu Ser Val Ala Ala   1 5 10 15 Ile Leu Glu Gly Asn Arg Ala Leu Val Gly Leu Leu Leu Ala Thr Thr              20 25 30 Leu Gly Leu Gly Val Ala Gln Trp Ile Gln Lys Val Val Ala Glu Asp          35 40 45 Leu Gly Gln His Tyr Val His Glu Val Arg Arg Glu Leu Val Gly Ala      50 55 60 Ala Leu Val Pro Gly Asn Thr Ala Ser Leu Gly Val Thr Val Thr Arg  65 70 75 80 Ala Ser Asn Asp Leu Thr Ala Val Arg Asn Trp Val Ala Leu Gly Ile                  85 90 95 Val Pro Met Val Thr Gly Leu Pro Leu Ile Ala Ile Val Leu Val Ala             100 105 110 Leu Phe Ile Gln Asp Leu Arg Thr Gly Val Ala Val Thr Val Pro Leu         115 120 125 Leu Met Cys Val Ala Val Leu Pro Val Val Ala Arg Trp Thr Leu Lys     130 135 140 Arg Ala Arg Glu Leu Arg Lys Lys Arg Gly Arg Met Ala Ala Arg Ile 145 150 155 160 Ala Asp Ser Val Met Ala Gly Glu Leu Leu His Ala Thr Gly Ala Ile                 165 170 175 Asp Arg Glu Leu Asn Ala Val Thr Arg Asp Ser Asp Arg Val Val Ile             180 185 190 Ala Ala Val Arg Arg Ser Trp Ala Thr Gly Phe Ser Arg Ala Leu Met         195 200 205 Ala Met Ala Ala Ser Leu Gly Thr Val Ser Ile Val Ile Ser Gly His     210 215 220 Leu Glu Val Ser Glu Val Ala Gly Ile Met Met Leu Leu Gly Val Leu 225 230 235 240 Ala Thr Pro Val Ala Glu Leu Gly Arg Val Val Glu Tyr Arg Gln Asn                 245 250 255 Tyr Lys Ala Ala Thr Arg Ile Leu Ile Pro Leu Leu Gln Arg Gly Ser             260 265 270 Glu Phe Lys His Ser Gln Gln Lys Leu Pro Gly Leu Gln Ala Thr Glu         275 280 285 Gly Ile Pro Gly Val Tyr Val Lys Gly Ile Ser Ala Leu Pro Gly Glu     290 295 300 Arg Ile Tyr Leu His Gly Ser Ala Asp Ala Thr Arg Lys Trp Val Thr 305 310 315 320 Ser Leu Ser Ala Met Glu Glu Gly Thr Asp Val Ile Val Asn Gly Gln                 325 330 335 Arg Leu Ser Gln Leu Pro Leu Lys Gln Arg Arg Ala Leu Ile Gly Ile             340 345 350 Ala Ser Ala His His His Leu Ser Arg Gly Ser Val Ser Arg Leu Val         355 360 365 Gly Leu Arg Val Pro Asp Ala Thr Val Glu Glu Ile Glu Gln Ala Leu     370 375 380 Glu Gln Val Gly Leu Asn Asn Thr Gly Lys Gln Arg Leu Lys Asn Gly 385 390 395 400 Gly His Pro Trp Ser Thr Ser Gln Ile Asn Lys Leu Lys Ile Ala Ser                 405 410 415 Ala Thr Leu Arg Thr Pro Pro Leu Leu Val Leu Glu Gly Ile Thr Pro             420 425 430 Glu Asn Leu Leu Asn Tyr Pro Gly Val Ile Ile Ser Thr Val Gln Glu         435 440 445 Asn Pro Ser Glu Thr Trp Arg Gln Val Asn Ile     450 455 <210> 303 <211> 412 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (412) <223> FRXA00456 <400> 303 ctcaccaacc cggagatcgt cacagcggtg ctaacggatc atgcctagct tatggcgtgc 60 tcgtcgcaga cttttgctca ttgccctagg tgtacttggt gtg ctg cag gca ctg 115                                             Val Leu Gln Ala Leu                                               1 5 ctg gcg atc atg gtg tcg ttg agc gta gcc gcc ata ctt gag gga aac 163 Leu Ala Ile Met Val Ser Leu Ser Val Ala Ala Ile Leu Glu Gly Asn                  10 15 20 cga gca ctt gtt gga ttg ctg ctt gct acc acg ttg ggt ttg ggg gtg 211 Arg Ala Leu Val Gly Leu Leu Leu Ala Thr Thr Leu Gly Leu Gly Val              25 30 35 gcg cag tgg att caa aaa gta gtg gca gaa gat cta ggc cag cat tat 259 Ala Gln Trp Ile Gln Lys Val Val Ala Glu Asp Leu Gly Gln His Tyr          40 45 50 gtg cat gag gtg cgt cgt gaa ttg gtg ggt gct gcg ctg gtg cct gga 307 Val His Glu Val Arg Arg Glu Leu Val Gly Ala Ala Leu Val Pro Gly      55 60 65 aat acg gcc tcg ttg ggc gtg act gtc acc cga gcc agc aat gat ctc 355 Asn Thr Ala Ser Leu Gly Val Thr Val Thr Arg Ala Ser Asn Asp Leu  70 75 80 85 acc gcg gtg cgc aat tgg gtg gct ttg ggc att gtt ccg atg gtc acc 403 Thr Ala Val Arg Asn Trp Val Ala Leu Gly Ile Val Pro Met Val Thr                  90 95 100 ggg ctg ccg 412 Gly leu pro <210> 304 <211> 104 <212> PRT <213> Corynebacterium glutamicum <400> 304 Val Leu Gln Ala Leu Leu Ala Ile Met Val Ser Leu Ser Val Ala Ala   1 5 10 15 Ile Leu Glu Gly Asn Arg Ala Leu Val Gly Leu Leu Leu Ala Thr Thr              20 25 30 Leu Gly Leu Gly Val Ala Gln Trp Ile Gln Lys Val Val Ala Glu Asp          35 40 45 Leu Gly Gln His Tyr Val His Glu Val Arg Arg Glu Leu Val Gly Ala      50 55 60 Ala Leu Val Pro Gly Asn Thr Ala Ser Leu Gly Val Thr Val Thr Arg  65 70 75 80 Ala Ser Asn Asp Leu Thr Ala Val Arg Asn Trp Val Ala Leu Gly Ile                  85 90 95 Val Pro Met Val Thr Gly Leu Pro             100 <210> 305 <211> 1040 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (31) .. (1017) <223> FRXA00459 <400> 305 aggcgtggct gttactgtgc cactgctcat gtg tgt acc cgt gct gcc ggt ggt 54                                  Val Cys Thr Arg Ala Ala Gly Gly                                    1 5 ggc gcg gtg act ttg aaa aga gca cgt gaa cta cgc aaa aaa cgt gga 102 Gly Ala Val Thr Leu Lys Arg Ala Arg Glu Leu Arg Lys Lys Arg Gly      10 15 20 cgc atg gct gcg cgg atc gca gat tct gtc atg gct gga gaa tta ctg 150 Arg Met Ala Ala Arg Ile Ala Asp Ser Val Met Ala Gly Glu Leu Leu  25 30 35 40 cac gca aca gga gca ata gac cgt gag ctc aat gca gtc acc cga gat 198 His Ala Thr Gly Ala Ile Asp Arg Glu Leu Asn Ala Val Thr Arg Asp                  45 50 55 tcc gac cga gtg gtg ata gct gct gta aga cgt tcc tgg gcc acc ggt 246 Ser Asp Arg Val Val Ile Ala Ala Val Arg Arg Ser Trp Ala Thr Gly              60 65 70 ttt agc cgc gca ttg atg gcc atg gca gcc tcg ctt ggc act gtc agc 294 Phe Ser Arg Ala Leu Met Ala Met Ala Ala Ser Leu Gly Thr Val Ser          75 80 85 att gtg att tct ggc cac ctg gaa gta agt gag gtt gcg gga ata atg 342 Ile Val Ile Ser Gly His Leu Glu Val Ser Glu Val Ala Gly Ile Met      90 95 100 atg ctt ctt ggc gtt ctt gcc act cca gtt gca gaa ctt ggc cgc gtg 390 Met Leu Leu Gly Val Leu Ala Thr Pro Val Ala Glu Leu Gly Arg Val 105 110 115 120 gtg gaa tat cgc caa aat tat aaa gcc gcg aca cgc atc ctg att cca 438 Val Glu Tyr Arg Gln Asn Tyr Lys Ala Ala Thr Arg Ile Leu Ile Pro                 125 130 135 ctt ctg caa cga ggc tca gaa ttt aaa cac tcc caa caa aaa cta ccc 486 Leu Leu Gln Arg Gly Ser Glu Phe Lys His Ser Gln Gln Lys Leu Pro             140 145 150 ggg ttg caa gca aca gaa gga atc ccc ggt gtc tat gtc aaa ggt att 534 Gly Leu Gln Ala Thr Glu Gly Ile Pro Gly Val Tyr Val Lys Gly Ile         155 160 165 tcc gcc ctt cct gga gaa cgg atc tac ctc cac ggc tct gca gat gcg 582 Ser Ala Leu Pro Gly Glu Arg Ile Tyr Leu His Gly Ser Ala Asp Ala     170 175 180 acg aga aaa tgg gtc acc tcg ttg tct gca atg gag gaa ggc aca gat 630 Thr Arg Lys Trp Val Thr Ser Leu Ser Ala Met Glu Glu Gly Thr Asp 185 190 195 200 gta ata gtc aac ggt caa agg ctt tcg cag ctt cct ttg aaa caa cga 678 Val Ile Val Asn Gly Gln Arg Leu Ser Gln Leu Pro Leu Lys Gln Arg                 205 210 215 cgc gcc ctc atc gga atc gcc tca gca cac cac cac tta agc cgt ggt 726 Arg Ala Leu Ile Gly Ile Ala Ser Ala His His His Leu Ser Arg Gly             220 225 230 tca gta tcg cgc ctg gtt ggt ttg cga gtg ccg gat gcc acc gtg gaa 774 Ser Val Ser Arg Leu Val Gly Leu Arg Val Pro Asp Ala Thr Val Glu         235 240 245 gaa att gag caa gca ctg gaa caa gtt ggt ctg aac aac acc ggg aaa 822 Glu Ile Glu Gln Ala Leu Glu Gln Val Gly Leu Asn Asn Thr Gly Lys     250 255 260 caa cgc ttg aaa aac ggc gga cac ccc tgg agt act tcg cag atc aac 870 Gln Arg Leu Lys Asn Gly Gly His Pro Trp Ser Thr Ser Gln Ile Asn 265 270 275 280 aaa ctg aaa att gcc agc gcc acc ctt cga acc cca ccg ctt ttg gta 918 Lys Leu Lys Ile Ala Ser Ala Thr Leu Arg Thr Pro Pro Leu Leu Val                 285 290 295 ctt gaa ggc atc acc cct gaa aac ctc ctc aac tat ccc gga gtg atc 966 Leu Glu Gly Ile Thr Pro Glu Asn Leu Leu Asn Tyr Pro Gly Val Ile             300 305 310 atc tcc acc gtt cag gag aac cca tcc gaa aca tgg cgg caa gtg aac 1014 Ile Ser Thr Val Gln Glu Asn Pro Ser Glu Thr Trp Arg Gln Val Asn         315 320 325 atc taatctagaa acatggcagg acg 1040 Ile <210> 306 <211> 329 <212> PRT <213> Corynebacterium glutamicum <400> 306 Val Cys Thr Arg Ala Ala Gly Gly Gly Ala Val Thr Leu Lys Arg Ala   1 5 10 15 Arg Glu Leu Arg Lys Lys Arg Gly Arg Met Ala Ala Arg Ile Ala Asp              20 25 30 Ser Val Met Ala Gly Glu Leu Leu His Ala Thr Gly Ala Ile Asp Arg          35 40 45 Glu Leu Asn Ala Val Thr Arg Asp Ser Asp Arg Val Val Ile Ala Ala      50 55 60 Val Arg Arg Ser Trp Ala Thr Gly Phe Ser Arg Ala Leu Met Ala Met  65 70 75 80 Ala Ala Ser Leu Gly Thr Val Ser Ile Val Ile Ser Gly His Leu Glu                  85 90 95 Val Ser Glu Val Ala Gly Ile Met Met Leu Leu Gly Val Leu Ala Thr             100 105 110 Pro Val Ala Glu Leu Gly Arg Val Val Glu Tyr Arg Gln Asn Tyr Lys         115 120 125 Ala Ala Thr Arg Ile Leu Ile Pro Leu Leu Gln Arg Gly Ser Glu Phe     130 135 140 Lys His Ser Gln Gln Lys Leu Pro Gly Leu Gln Ala Thr Glu Gly Ile 145 150 155 160 Pro Gly Val Tyr Val Lys Gly Ile Ser Ala Leu Pro Gly Glu Arg Ile                 165 170 175 Tyr Leu His Gly Ser Ala Asp Ala Thr Arg Lys Trp Val Thr Ser Leu             180 185 190 Ser Ala Met Glu Glu Gly Thr Asp Val Ile Val Asn Gly Gln Arg Leu         195 200 205 Ser Gln Leu Pro Leu Lys Gln Arg Arg Ala Leu Ile Gly Ile Ala Ser     210 215 220 Ala His His His Leu Ser Arg Gly Ser Val Ser Arg Leu Val Gly Leu 225 230 235 240 Arg Val Pro Asp Ala Thr Val Glu Glu Ile Glu Gln Ala Leu Glu Gln                 245 250 255 Val Gly Leu Asn Asn Thr Gly Lys Gln Arg Leu Lys Asn Gly Gly His             260 265 270 Pro Trp Ser Thr Ser Gln Ile Asn Lys Leu Lys Ile Ala Ser Ala Thr         275 280 285 Leu Arg Thr Pro Pro Leu Leu Val Leu Glu Gly Ile Thr Pro Glu Asn     290 295 300 Leu Leu Asn Tyr Pro Gly Val Ile Ile Ser Thr Val Gln Glu Asn Pro 305 310 315 320 Ser Glu Thr Trp Arg Gln Val Asn Ile                 325 <210> 307 <211> 771 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (748) <223> RXN01604 <400> 307 ctctcatgtt gttgtcctct agttgacagc gggggtggtg gtggtcctaa aatagcctac 60 gataactgat agtgtttcct ccacttacgg aagaagatac atg aat acc cct ctt 115                                             Met Asn Thr Pro Leu                                               1 5 ttg aga agc tct ggg ctc tcc atc cgc gac aca ccc ttc gcc gat gtt 163 Leu Arg Ser Ser Gly Leu Ser Ile Arg Asp Thr Pro Phe Ala Asp Val                  10 15 20 gag ata gct cca gac agc gga ctc act ttg ctg agc acc ggg cgc gaa 211 Glu Ile Ala Pro Asp Ser Gly Leu Thr Leu Leu Ser Thr Gly Arg Glu              25 30 35 tcc caa tcc agt tcc ttt tct ttg gta ctt tcc ggc cgc atg cgc gcc 259 Ser Gln Ser Ser Ser Phe Ser Leu Val Leu Ser Gly Arg Met Arg Ala          40 45 50 tcc acc gga acc atc gaa tta aac ggc gaa ccc atc aag gca acc aag 307 Ser Thr Gly Thr Ile Glu Leu Asn Gly Glu Pro Ile Lys Ala Thr Lys      55 60 65 ctg gcc aag cat gtg gct ttg gcg ggc atc cct gaa atc gat tca ctc 355 Leu Ala Lys His Val Ala Leu Ala Gly Ile Pro Glu Ile Asp Ser Leu  70 75 80 85 gag cga ctt gtc act gtg cgc acc gtt gtc cgt gaa caa ctc gcc tgg 403 Glu Arg Leu Val Thr Val Arg Thr Val Val Arg Glu Gln Leu Ala Trp                  90 95 100 tca agc cct tgg tac ctg atg gtg ccc agg gat att agt gat tcg gga 451 Ser Ser Pro Trp Tyr Leu Met Val Pro Arg Asp Ile Ser Asp Ser Gly             105 110 115 cgg tgg gtt gac gtc gaa aag cat ctt ggc ctg aac ctg aac cct aaa 499 Arg Trp Val Asp Val Glu Lys His Leu Gly Leu Asn Leu Asn Pro Lys         120 125 130 acc tta atc ggc gac ctc agc gtg ctc gag cgt ttt aag ctg cgc atc 547 Thr Leu Ile Gly Asp Leu Ser Val Leu Glu Arg Phe Lys Leu Arg Ile     135 140 145 gcg ctg gcg ctg ctg gcg cgg cca gag gcg caa ctg ttg gtc gtg gat 595 Ala Leu Ala Leu Leu Ala Arg Pro Glu Ala Gln Leu Leu Val Val Asp 150 155 160 165 gat ccc gat caa gtg cgc agc atg gaa ttg cgt gcg gag gtg ttg cac 643 Asp Pro Asp Gln Val Arg Ser Met Glu Leu Arg Ala Glu Val Leu His                 170 175 180 gca ttg aaa ggc gtt gca gag gat ctc cct gtg gtc gtg gta tcc acc 691 Ala Leu Lys Gly Val Ala Glu Asp Leu Pro Val Val Val Val Ser Thr             185 190 195 aac cca gat ttt gat tcc ttg gcc gat acc gct ttg acc att acg ggg 739 Asn Pro Asp Phe Asp Ser Leu Ala Asp Thr Ala Leu Thr Ile Thr Gly         200 205 210 gct gga aac taatggcatt tttacacttt ggc 771 Ala gly asn     215 <210> 308 <211> 216 <212> PRT <213> Corynebacterium glutamicum <400> 308 Met Asn Thr Pro Leu Leu Arg Ser Ser Gly Leu Ser Ile Arg Asp Thr   1 5 10 15 Pro Phe Ala Asp Val Glu Ile Ala Pro Asp Ser Gly Leu Thr Leu Leu              20 25 30 Ser Thr Gly Arg Glu Ser Gln Ser Ser Ser Phe Ser Leu Val Leu Ser          35 40 45 Gly Arg Met Arg Ala Ser Thr Gly Thr Ile Glu Leu Asn Gly Glu Pro      50 55 60 Ile Lys Ala Thr Lys Leu Ala Lys His Val Ala Leu Ala Gly Ile Pro  65 70 75 80 Glu Ile Asp Ser Leu Glu Arg Leu Val Thr Val Arg Thr Val Val Arg                  85 90 95 Glu Gln Leu Ala Trp Ser Ser Pro Trp Tyr Leu Met Val Pro Arg Asp             100 105 110 Ile Ser Asp Ser Gly Arg Trp Val Asp Val Glu Lys His Leu Gly Leu         115 120 125 Asn Leu Asn Pro Lys Thr Leu Ile Gly Asp Leu Ser Val Leu Glu Arg     130 135 140 Phe Lys Leu Arg Ile Ala Leu Ala Leu Leu Ala Arg Pro Glu Ala Gln 145 150 155 160 Leu Leu Val Val Asp Asp Pro Asp Gln Val Arg Ser Met Glu Leu Arg                 165 170 175 Ala Glu Val Leu His Ala Leu Lys Gly Val Ala Glu Asp Leu Pro Val             180 185 190 Val Val Val Ser Thr Asn Pro Asp Phe Asp Ser Leu Ala Asp Thr Ala         195 200 205 Leu Thr Ile Thr Gly Ala Gly Asn     210 215 <210> 309 <211> 629 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (1) .. (606) <223> FRXA01604 <400> 309 gac aca ccc ttc gcc gat gtt gag ata gct cca gac agc gga ctc act 48 Asp Thr Pro Phe Ala Asp Val Glu Ile Ala Pro Asp Ser Gly Leu Thr   1 5 10 15 ttg ctg agc acc ggg cgc gaa tcc caa tcc agt tcc ttt tct ttg gta 96 Leu Leu Ser Thr Gly Arg Glu Ser Gln Ser Ser Ser Phe Ser Leu Val              20 25 30 ctt tcc ggc cgc atg cgc gcc tcc acc gga acc atc gaa tta aac ggc 144 Leu Ser Gly Arg Met Arg Ala Ser Thr Gly Thr Ile Glu Leu Asn Gly          35 40 45 gaa ccc atc aag gca acc aag ctg gcc aag cat gtg gct ttg gcg ggc 192 Glu Pro Ile Lys Ala Thr Lys Leu Ala Lys His Val Ala Leu Ala Gly      50 55 60 atc cct gaa atc gat tca ctc gag cga ctt gtc act gtg cgc acc gtt 240 Ile Pro Glu Ile Asp Ser Leu Glu Arg Leu Val Thr Val Arg Thr Val  65 70 75 80 gtc cgt gaa caa ctc gcc tgg tca agc cct tgg tac ctg atg gtg ccc 288 Val Arg Glu Gln Leu Ala Trp Ser Ser Pro Trp Tyr Leu Met Val Pro                  85 90 95 agg gat att agt gat tcg gga cgg tgg gtt gac gtc gaa aag cat ctt 336 Arg Asp Ile Ser Asp Ser Gly Arg Trp Val Asp Val Glu Lys His Leu             100 105 110 ggc ctg aac ctg aac cct aaa acc tta atc ggc gac ctc agc gtg ctc 384 Gly Leu Asn Leu Asn Pro Lys Thr Leu Ile Gly Asp Leu Ser Val Leu         115 120 125 gag cgt ttt aag ctg cgc atc gcg ctg gcg ctg ctg gcg cgg cca gag 432 Glu Arg Phe Lys Leu Arg Ile Ala Leu Ala Leu Leu Ala Arg Pro Glu     130 135 140 gcg caa ctg ttg gtc gtg gat gat ccc gat caa gtg cgc agc atg gaa 480 Ala Gln Leu Leu Val Val Asp Asp Pro Asp Gln Val Arg Ser Met Glu 145 150 155 160 ttg cgt gcg gag gtg ttg cac gca ttg aaa ggc gtt gca gag gat ctc 528 Leu Arg Ala Glu Val Leu His Ala Leu Lys Gly Val Ala Glu Asp Leu                 165 170 175 cct gtg gtc gtg gta tcc acc aac cca gat ttt gat tcc ttg gcc gat 576 Pro Val Val Val Val Ser Thr Asn Pro Asp Phe Asp Ser Leu Ala Asp             180 185 190 acc gct ttg acc att acg ggg gct gga aac taatggcatt tttacacttt 626 Thr Ala Leu Thr Ile Thr Gly Ala Gly Asn         195 200 ggc 629 <210> 310 <211> 202 <212> PRT <213> Corynebacterium glutamicum <400> 310 Asp Thr Pro Phe Ala Asp Val Glu Ile Ala Pro Asp Ser Gly Leu Thr   1 5 10 15 Leu Leu Ser Thr Gly Arg Glu Ser Gln Ser Ser Ser Phe Ser Leu Val              20 25 30 Leu Ser Gly Arg Met Arg Ala Ser Thr Gly Thr Ile Glu Leu Asn Gly          35 40 45 Glu Pro Ile Lys Ala Thr Lys Leu Ala Lys His Val Ala Leu Ala Gly      50 55 60 Ile Pro Glu Ile Asp Ser Leu Glu Arg Leu Val Thr Val Arg Thr Val  65 70 75 80 Val Arg Glu Gln Leu Ala Trp Ser Ser Pro Trp Tyr Leu Met Val Pro                  85 90 95 Arg Asp Ile Ser Asp Ser Gly Arg Trp Val Asp Val Glu Lys His Leu             100 105 110 Gly Leu Asn Leu Asn Pro Lys Thr Leu Ile Gly Asp Leu Ser Val Leu         115 120 125 Glu Arg Phe Lys Leu Arg Ile Ala Leu Ala Leu Leu Ala Arg Pro Glu     130 135 140 Ala Gln Leu Leu Val Val Asp Asp Pro Asp Gln Val Arg Ser Met Glu 145 150 155 160 Leu Arg Ala Glu Val Leu His Ala Leu Lys Gly Val Ala Glu Asp Leu                 165 170 175 Pro Val Val Val Val Ser Thr Asn Pro Asp Phe Asp Ser Leu Ala Asp             180 185 190 Thr Ala Leu Thr Ile Thr Gly Ala Gly Asn         195 200 <210> 311 <211> 2262 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (2239) <223> RXN02547 <400> 311 ggggccgtcg ataagcgaag aacaattagc actgcgcgcg ctggtctgac gcattggtta 60 aggggctggc ggtccggcgc cggaatcggc ggaggagctt ttg gag ctc aac aac 115                                             Leu Glu Leu Asn Asn                                               1 5 gct gcg cgg ctg acc gtg gat gag tat ccg gcg gcg agg gaa gcg ctt 163 Ala Ala Arg Leu Thr Val Asp Glu Tyr Pro Ala Ala Arg Glu Ala Leu                  10 15 20 gaa tct gca ggt cag agg aat gta gag gac cga acc cgt gcg gtt gat 211 Glu Ser Ala Gly Gln Arg Asn Val Glu Asp Arg Thr Arg Ala Val Asp              25 30 35 gag ttc aaa gcg gcg gat caa gag ctg tct tct ttg agt aaa ggc agc 259 Glu Phe Lys Ala Ala Asp Gln Glu Leu Ser Ser Leu Ser Lys Gly Ser          40 45 50 agt aat att gag tac cgt ttg ctg cag gtg cgg gaa aat ttg tgt cag 307 Ser Asn Ile Glu Tyr Arg Leu Leu Gln Val Arg Glu Asn Leu Cys Gln      55 60 65 gat ttg ggc gtg agc ccg cgg gat atg ccc ttt gcc ggt gag ctg att 355 Asp Leu Gly Val Ser Pro Arg Asp Met Pro Phe Ala Gly Glu Leu Ile  70 75 80 85 gat ccg aat aat gcg gaa tgg gaa ccc gtt gtg cag cgc att ttg ggt 403 Asp Pro Asn Asn Ala Glu Trp Glu Pro Val Val Gln Arg Ile Leu Gly                  90 95 100 ggt ttt gct gcg gaa atg ttg gtt cct cat ggg ttg ttg cca cgg gtt 451 Gly Phe Ala Ala Glu Met Leu Val Pro His Gly Leu Leu Pro Arg Val             105 110 115 cgg gat tgg gta aat gcc aaa cat ttg gca gcg ctg ctg aaa ttc aac 499 Arg Asp Trp Val Asn Ala Lys His Leu Ala Ala Leu Leu Lys Phe Asn         120 125 130 ggc gtg gtg aca acg ggg gag tac aaa acc tcg cgt ttt ccg gcg gat 547 Gly Val Val Thr Thr Gly Glu Tyr Lys Thr Ser Arg Phe Pro Ala Asp     135 140 145 tcc ctg atc cga aaa gtt gat gtt gtg gag tcg ccg ttt cgc gat tgg 595 Ser Leu Ile Arg Lys Val Asp Val Val Glu Ser Pro Phe Arg Asp Trp 150 155 160 165 gta aat caa gaa tta ggc aag cgt ttt aat att cgg tgc gtg cgc act 643 Val Asn Gln Glu Leu Gly Lys Arg Phe Asn Ile Arg Cys Val Arg Thr                 170 175 180 cct gag gaa ttg tcg gcg ctg ggg cca cgc gat cag ggc gtg acc att 691 Pro Glu Glu Leu Ser Ala Leu Gly Pro Arg Asp Gln Gly Val Thr Ile             185 190 195 ttg ggt gtg cga aaa ttt gcg cag cag aca ggc gat ccg acg acg cgt 739 Leu Gly Val Arg Lys Phe Ala Gln Gln Thr Gly Asp Pro Thr Thr Arg         200 205 210 tgg gaa aaa gat gat cgc cga aag ctg ggg gat cgt tcc aca tac cgt 787 Trp Glu Lys Asp Asp Arg Arg Lys Leu Gly Asp Arg Ser Thr Tyr Arg     215 220 225 ttg ggt tcc acc aat gat gcc aag gtg gaa acg ctt cgg gaa acc gtg 835 Leu Gly Ser Thr Asn Asp Ala Lys Val Glu Thr Leu Arg Glu Thr Val 230 235 240 245 aaa gct ggc aaa gca gtt gtg cag gca gct gat aat cgc att gct gca 883 Lys Ala Gly Lys Ala Val Val Gln Ala Ala Asp Asn Arg Ile Ala Ala                 250 255 260 aac cgc gct gag ctg cgg gaa ctt gaa cgg cag tat caa gct tcg caa 931 Asn Arg Ala Glu Leu Arg Glu Leu Glu Arg Gln Tyr Gln Ala Ser Gln             265 270 275 gaa att ttg aaa gtg tcg tgg gct cag att gat gtg gaa tca gcc gac 979 Glu Ile Leu Lys Val Ser Trp Ala Gln Ile Asp Val Glu Ser Ala Asp         280 285 290 gcg gcg att gct gag ctg gac cga ttg ctg gaa gag ctg aac aac act 1027 Ala Ala Ile Ala Glu Leu Asp Arg Leu Leu Glu Glu Leu Asn Asn Thr     295 300 305 cca gag gcc acc gag ctt tcc gcg cgg cat gag gcg gcg aag cag acg 1075 Pro Glu Ala Thr Glu Leu Ser Ala Arg His Glu Ala Ala Lys Gln Thr 310 315 320 325 ctc gcg agg gtt tct gac ttg ctt gtc gca gct cag agt gag gaa acc 1123 Leu Ala Arg Val Ser Asp Leu Leu Val Ala Ala Gln Ser Glu Glu Thr                 330 335 340 gtg gcg tcg atg aac ctg aaa cgc gcc gaa act gaa ttg aaa cgg ctc 1171 Val Ala Ser Met Asn Leu Lys Arg Ala Glu Thr Glu Leu Lys Arg Leu             345 350 355 gaa agc ctg ccg gtt gcg gag gtt tct gaa gaa atc gcg cgg gaa gtg 1219 Glu Ser Leu Pro Val Ala Glu Val Ser Glu Glu Ile Ala Arg Glu Val         360 365 370 gag aaa cta ttt ctt gcc aac acc cgc cgg gtt cac gcc gcc aac gtg 1267 Glu Lys Leu Phe Leu Ala Asn Thr Arg Arg Val His Ala Ala Asn Val     375 380 385 gat gag cag acc att gcg ctg cgc gag gat ctg gac aaa caa atc gat 1315 Asp Glu Gln Thr Ile Ala Leu Arg Glu Asp Leu Asp Lys Gln Ile Asp 390 395 400 405 gcc aat gag gca gaa ctt cga cgt tgt gaa aac caa att gtt ggc att 1363 Ala Asn Glu Ala Glu Leu Arg Arg Cys Glu Asn Gln Ile Val Gly Ile                 410 415 420 ttg cgc agc tat att gaa acg tgg cct gcg aac cgc gct gac tta caa 1411 Leu Arg Ser Tyr Ile Glu Thr Trp Pro Ala Asn Arg Ala Asp Leu Gln             425 430 435 gcc gaa cct gag ttt gtt ggt gag gcc atc aac cgc ctc ggc gag ctt 1459 Ala Glu Pro Glu Phe Val Gly Glu Ala Ile Asn Arg Leu Gly Glu Leu         440 445 450 cgc agc gat cgt ttg gca gaa ttc acg gcc aaa ttc cta ggg ctc atg 1507 Arg Ser Asp Arg Leu Ala Glu Phe Thr Ala Lys Phe Leu Gly Leu Met     455 460 465 aac gag atg tcc acc cga aac ctc ggc caa atc tcg cgg cgt cta cgt 1555 Asn Glu Met Ser Thr Arg Asn Leu Gly Gln Ile Ser Arg Arg Leu Arg 470 475 480 485 gat gcg cgc cgg gaa atc gag gag cgc atc gag ccg atc aac gcc tcc 1603 Asp Ala Arg Arg Glu Ile Glu Glu Arg Ile Glu Pro Ile Asn Ala Ser                 490 495 500 ttg gcg cag tcg gaa ttc aac gaa ggt cgc ttc ctg cac atc gac atc 1651 Leu Ala Gln Ser Glu Phe Asn Glu Gly Arg Phe Leu His Ile Asp Ile             505 510 515 cgt gat caa agt ggt ccg att gtg agg gaa ttc cag cag aaa ctt gat 1699 Arg Asp Gln Ser Gly Pro Ile Val Arg Glu Phe Gln Gln Lys Leu Asp         520 525 530 gcc gct acc agc ggt gac ctg gga acc agt acc gag aaa caa gcc ttc 1747 Ala Ala Thr Ser Gly Asp Leu Gly Thr Ser Thr Glu Lys Gln Ala Phe     535 540 545 gcc cgt tat gcg ctg atc gct gaa atc att tcc aaa ctc gcc tcc cac 1795 Ala Arg Tyr Ala Leu Ile Ala Glu Ile Ile Ser Lys Leu Ala Ser His 550 555 560 565 gac tcc gcc gac gcc cgc tgg cgc aac acc gtt cta gac acc cgc cgc 1843 Asp Ser Ala Asp Ala Arg Trp Arg Asn Thr Val Leu Asp Thr Arg Arg                 570 575 580 cac gtt cgc ttc atc ggc ctc gag cgc gat tcc gac ggc gca acc gtc 1891 His Val Arg Phe Ile Gly Leu Glu Arg Asp Ser Asp Gly Ala Thr Val             585 590 595 aac acc tac gtc gac tcc gca tca ctt tca ggc gga caa gcc cag aag 1939 Asn Thr Tyr Val Asp Ser Ala Ser Leu Ser Gly Gly Gln Ala Gln Lys         600 605 610 ctg gtg ttt ttc tgc ctc gcc gct gcc ttg cgc tac cag cta gcc gaa 1987 Leu Val Phe Phe Cys Leu Ala Ala Ala Leu Arg Tyr Gln Leu Ala Glu     615 620 625 ccc ggc gcc cat tat ccc acc tac gcc acc gtc att ctg gac gaa gcc 2035 Pro Gly Ala His Tyr Pro Thr Tyr Ala Thr Val Ile Leu Asp Glu Ala 630 635 640 645 ttc gac cgc gcc gac ccc gcc ttc acc cgc caa acc atg aac gtc ttc 2083 Phe Asp Arg Ala Asp Pro Ala Phe Thr Arg Gln Thr Met Asn Val Phe                 650 655 660 cac agc ttc ggc ttc cac atg gtg ctc gcg acc ccg ctg aaa ctt atc 2131 His Ser Phe Gly Phe His Met Val Leu Ala Thr Pro Leu Lys Leu Ile             665 670 675 caa acc ctc ggc gat tat gtc ggc tcc acc atc gtg gtc agc tac acc 2179 Gln Thr Leu Gly Asp Tyr Val Gly Ser Thr Ile Val Val Ser Tyr Thr         680 685 690 gaa aaa cca aac gcc cag ggc gca att cag ggc aat tcc agt ttc tct 2227 Glu Lys Pro Asn Ala Gln Gly Ala Ile Gln Gly Asn Ser Ser Phe Ser     695 700 705 agg atc gag aaa taacatgcca ttgtttatcg acg 2262 Arg Ile Glu Lys 710 <210> 312 <211> 713 <212> PRT <213> Corynebacterium glutamicum <400> 312 Leu Glu Leu Asn Asn Ala Ala Arg Leu Thr Val Asp Glu Tyr Pro Ala   1 5 10 15 Ala Arg Glu Ala Leu Glu Ser Ala Gly Gln Arg Asn Val Glu Asp Arg              20 25 30 Thr Arg Ala Val Asp Glu Phe Lys Ala Ala Asp Gln Glu Leu Ser Ser          35 40 45 Leu Ser Lys Gly Ser Ser Asn Ile Glu Tyr Arg Leu Leu Gln Val Arg      50 55 60 Glu Asn Leu Cys Gln Asp Leu Gly Val Ser Pro Arg Asp Met Pro Phe  65 70 75 80 Ala Gly Glu Leu Ile Asp Pro Asn Asn Ala Glu Trp Glu Pro Val Val                  85 90 95 Gln Arg Ile Leu Gly Gly Phe Ala Ala Glu Met Leu Val Pro His Gly             100 105 110 Leu Leu Pro Arg Val Arg Asp Trp Val Asn Ala Lys His Leu Ala Ala         115 120 125 Leu Leu Lys Phe Asn Gly Val Val Thr Thr Gly Glu Tyr Lys Thr Ser     130 135 140 Arg Phe Pro Ala Asp Ser Leu Ile Arg Lys Val Asp Val Val Glu Ser 145 150 155 160 Pro Phe Arg Asp Trp Val Asn Gln Glu Leu Gly Lys Arg Phe Asn Ile                 165 170 175 Arg Cys Val Arg Thr Pro Glu Glu Leu Ser Ala Leu Gly Pro Arg Asp             180 185 190 Gln Gly Val Thr Ile Leu Gly Val Arg Lys Phe Ala Gln Gln Thr Gly         195 200 205 Asp Pro Thr Thr Arg Trp Glu Lys Asp Asp Arg Arg Lys Leu Gly Asp     210 215 220 Arg Ser Thr Tyr Arg Leu Gly Ser Thr Asn Asp Ala Lys Val Glu Thr 225 230 235 240 Leu Arg Glu Thr Val Lys Ala Gly Lys Ala Val Val Gln Ala Ala Asp                 245 250 255 Asn Arg Ile Ala Ala Asn Arg Ala Glu Leu Arg Glu Leu Glu Arg Gln             260 265 270 Tyr Gln Ala Ser Gln Glu Ile Leu Lys Val Ser Trp Ala Gln Ile Asp         275 280 285 Val Glu Ser Ala Asp Ala Ala Ile Ala Glu Leu Asp Arg Leu Leu Glu     290 295 300 Glu Leu Asn Asn Thr Pro Glu Ala Thr Glu Leu Ser Ala Arg His Glu 305 310 315 320 Ala Ala Lys Gln Thr Leu Ala Arg Val Ser Asp Leu Leu Val Ala Ala                 325 330 335 Gln Ser Glu Glu Thr Val Ala Ser Met Asn Leu Lys Arg Ala Glu Thr             340 345 350 Glu Leu Lys Arg Leu Glu Ser Leu Pro Val Ala Glu Val Ser Glu Glu         355 360 365 Ile Ala Arg Glu Val Glu Lys Leu Phe Leu Ala Asn Thr Arg Arg Val     370 375 380 His Ala Ala Asn Val Asp Glu Gln Thr Ile Ala Leu Arg Glu Asp Leu 385 390 395 400 Asp Lys Gln Ile Asp Ala Asn Glu Ala Glu Leu Arg Arg Cys Glu Asn                 405 410 415 Gln Ile Val Gly Ile Leu Arg Ser Tyr Ile Glu Thr Trp Pro Ala Asn             420 425 430 Arg Ala Asp Leu Gln Ala Glu Pro Glu Phe Val Gly Glu Ala Ile Asn         435 440 445 Arg Leu Gly Glu Leu Arg Ser Asp Arg Leu Ala Glu Phe Thr Ala Lys     450 455 460 Phe Leu Gly Leu Met Asn Glu Met Ser Thr Arg Asn Leu Gly Gln Ile 465 470 475 480 Ser Arg Arg Leu Arg Asp Ala Arg Arg Glu Ile Glu Glu Arg Ile Glu                 485 490 495 Pro Ile Asn Ala Ser Leu Ala Gln Ser Glu Phe Asn Glu Gly Arg Phe             500 505 510 Leu His Ile Asp Ile Arg Asp Gln Ser Gly Pro Ile Val Arg Glu Phe         515 520 525 Gln Gln Lys Leu Asp Ala Ala Thr Ser Gly Asp Leu Gly Thr Ser Thr     530 535 540 Glu Lys Gln Ala Phe Ala Arg Tyr Ala Leu Ile Ala Glu Ile Ile Ser 545 550 555 560 Lys Leu Ala Ser His Asp Ser Ala Asp Ala Arg Trp Arg Asn Thr Val                 565 570 575 Leu Asp Thr Arg Arg His Val Arg Phe Ile Gly Leu Glu Arg Asp Ser             580 585 590 Asp Gly Ala Thr Val Asn Thr Tyr Val Asp Ser Ala Ser Leu Ser Gly         595 600 605 Gly Gln Ala Gln Lys Leu Val Phe Phe Cys Leu Ala Ala Ala Leu Arg     610 615 620 Tyr Gln Leu Ala Glu Pro Gly Ala His Tyr Pro Thr Tyr Ala Thr Val 625 630 635 640 Ile Leu Asp Glu Ala Phe Asp Arg Ala Asp Pro Ala Phe Thr Arg Gln                 645 650 655 Thr Met Asn Val Phe His Ser Phe Gly Phe His Met Val Leu Ala Thr             660 665 670 Pro Leu Lys Leu Ile Gln Thr Leu Gly Asp Tyr Val Gly Ser Thr Ile         675 680 685 Val Val Ser Tyr Thr Glu Lys Pro Asn Ala Gln Gly Ala Ile Gln Gly     690 695 700 Asn Ser Ser Phe Ser Arg Ile Glu Lys 705 710 <210> 313 <211> 2147 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (2124) <223> FRXA02547 <400> 313 gct gcg cgg ctg acc gtg gat gag tat ccg gcg gcg agg gaa gcg ctt 48 Ala Ala Arg Leu Thr Val Asp Glu Tyr Pro Ala Ala Arg Glu Ala Leu   1 5 10 15 gaa tct gca ggt cag agg aat gta gag gac cga acc cgt gcg gtt gat 96 Glu Ser Ala Gly Gln Arg Asn Val Glu Asp Arg Thr Arg Ala Val Asp              20 25 30 gag ttc aaa gcg gcg gat caa gag ctg tct tct ttg agt aaa ggc agc 144 Glu Phe Lys Ala Ala Asp Gln Glu Leu Ser Ser Leu Ser Lys Gly Ser          35 40 45 agt aat att gag tac cgt ttg ctg cag gtg cgg gaa aat ttg tgt cag 192 Ser Asn Ile Glu Tyr Arg Leu Leu Gln Val Arg Glu Asn Leu Cys Gln      50 55 60 gat ttg ggc gtg agc ccg cgg gat atg ccc ttt gcc ggt gag ctg att 240 Asp Leu Gly Val Ser Pro Arg Asp Met Pro Phe Ala Gly Glu Leu Ile  65 70 75 80 gat ccg aat aat gcg gaa tgg gaa ccc gtt gtg cag cgc att ttg ggt 288 Asp Pro Asn Asn Ala Glu Trp Glu Pro Val Val Gln Arg Ile Leu Gly                  85 90 95 ggt ttt gct gcg gaa atg ttg gtt cct cat ggg ttg ttg cca cgg gtt 336 Gly Phe Ala Ala Glu Met Leu Val Pro His Gly Leu Leu Pro Arg Val             100 105 110 cgg gat tgg gta aat gcc aaa cat ttg gca gcg ctg ctg aaa ttc aac 384 Arg Asp Trp Val Asn Ala Lys His Leu Ala Ala Leu Leu Lys Phe Asn         115 120 125 ggc gtg gtg aca acg ggg gag tac aaa acc tcg cgt ttt ccg gcg gat 432 Gly Val Val Thr Thr Gly Glu Tyr Lys Thr Ser Arg Phe Pro Ala Asp     130 135 140 tcc ctg atc cga aaa gtt gat gtt gtg gag tcg ccg ttt cgc gat tgg 480 Ser Leu Ile Arg Lys Val Asp Val Val Glu Ser Pro Phe Arg Asp Trp 145 150 155 160 gta aat caa gaa tta ggc aag cgt ttt aat att cgg tgc gtg cgc act 528 Val Asn Gln Glu Leu Gly Lys Arg Phe Asn Ile Arg Cys Val Arg Thr                 165 170 175 cct gag gaa ttg tcg gcg ctg ggg cca cgc gat cag ggc gtg acc att 576 Pro Glu Glu Leu Ser Ala Leu Gly Pro Arg Asp Gln Gly Val Thr Ile             180 185 190 ttg ggt gtg cga aaa ttt gcg cag cag aca ggc gat ccg acg acg cgt 624 Leu Gly Val Arg Lys Phe Ala Gln Gln Thr Gly Asp Pro Thr Thr Arg         195 200 205 tgg gaa aaa gat gat cgc cga aag ctg ggg gat cgt tcc aca tac cgt 672 Trp Glu Lys Asp Asp Arg Arg Lys Leu Gly Asp Arg Ser Thr Tyr Arg     210 215 220 ttg ggt tcc acc aat gat gcc aag gtg gaa acg ctt cgg gaa acc gtg 720 Leu Gly Ser Thr Asn Asp Ala Lys Val Glu Thr Leu Arg Glu Thr Val 225 230 235 240 aaa gct ggc aaa gca gtt gtg cag gca gct gat aat cgc att gct gca 768 Lys Ala Gly Lys Ala Val Val Gln Ala Ala Asp Asn Arg Ile Ala Ala                 245 250 255 aac cgc gct gag ctg cgg gaa ctt gaa cgg cag tat caa gct tcg caa 816 Asn Arg Ala Glu Leu Arg Glu Leu Glu Arg Gln Tyr Gln Ala Ser Gln             260 265 270 gaa att ttg aaa gtg tcg tgg gct cag att gat gtg gaa tca gcc gac 864 Glu Ile Leu Lys Val Ser Trp Ala Gln Ile Asp Val Glu Ser Ala Asp         275 280 285 gcg gcg att gct gag ctg gac cga ttg ctg gaa gag ctg aac aac act 912 Ala Ala Ile Ala Glu Leu Asp Arg Leu Leu Glu Glu Leu Asn Asn Thr     290 295 300 cca gag gcc acc gag ctt tcc gcg cgg cat gag gcg gcg aag cag acg 960 Pro Glu Ala Thr Glu Leu Ser Ala Arg His Glu Ala Ala Lys Gln Thr 305 310 315 320 ctc gcg agg gtt tct gac ttg ctt gtc gca gct cag agt gag gaa acc 1008 Leu Ala Arg Val Ser Asp Leu Leu Val Ala Ala Gln Ser Glu Glu Thr                 325 330 335 gtg gcg tcg atg aac ctg aaa cgc gcc gaa act gaa ttg aaa cgg ctc 1056 Val Ala Ser Met Asn Leu Lys Arg Ala Glu Thr Glu Leu Lys Arg Leu             340 345 350 gaa agc ctg ccg gtt gcg gag gtt tct gaa gaa atc gcg cgg gaa gtg 1104 Glu Ser Leu Pro Val Ala Glu Val Ser Glu Glu Ile Ala Arg Glu Val         355 360 365 gag aaa cta ttt ctt gcc aac acc cgc cgg gtt cac gcc gcc aac gtg 1152 Glu Lys Leu Phe Leu Ala Asn Thr Arg Arg Val His Ala Ala Asn Val     370 375 380 gat gag cag acc att gcg ctg cgc gag gat ctg gac aaa caa atc gat 1200 Asp Glu Gln Thr Ile Ala Leu Arg Glu Asp Leu Asp Lys Gln Ile Asp 385 390 395 400 gcc aat gag gca gaa ctt cga cgt tgt gaa aac caa att gtt ggc att 1248 Ala Asn Glu Ala Glu Leu Arg Arg Cys Glu Asn Gln Ile Val Gly Ile                 405 410 415 ttg cgc agc tat att gaa acg tgg cct gcg aac cgc gct gac tta caa 1296 Leu Arg Ser Tyr Ile Glu Thr Trp Pro Ala Asn Arg Ala Asp Leu Gln             420 425 430 gcc gaa cct gag ttt gtt ggt gag gcc atc aac cgc ctc ggc gag ctt 1344 Ala Glu Pro Glu Phe Val Gly Glu Ala Ile Asn Arg Leu Gly Glu Leu         435 440 445 cgc agc gat cgt ttg gca gaa ttc acg gcc aaa ttc cta ggg ctc atg 1392 Arg Ser Asp Arg Leu Ala Glu Phe Thr Ala Lys Phe Leu Gly Leu Met     450 455 460 aac gag atg tcc acc cga aac ctc ggc caa atc tcg cgg cgt cta cgt 1440 Asn Glu Met Ser Thr Arg Asn Leu Gly Gln Ile Ser Arg Arg Leu Arg 465 470 475 480 gat gcg cgc cgg gaa atc gag gag cgc atc gag ccg atc aac gcc tcc 1488 Asp Ala Arg Arg Glu Ile Glu Glu Arg Ile Glu Pro Ile Asn Ala Ser                 485 490 495 ttg gcg cag tcg gaa ttc aac gaa ggt cgc ttc ctg cac atc gac atc 1536 Leu Ala Gln Ser Glu Phe Asn Glu Gly Arg Phe Leu His Ile Asp Ile             500 505 510 cgt gat caa agt ggt ccg att gtg agg gaa ttc cag cag aaa ctt gat 1584 Arg Asp Gln Ser Gly Pro Ile Val Arg Glu Phe Gln Gln Lys Leu Asp         515 520 525 gcc gct acc agc ggt gac ctg gga acc agt acc gag aaa caa gcc ttc 1632 Ala Ala Thr Ser Gly Asp Leu Gly Thr Ser Thr Glu Lys Gln Ala Phe     530 535 540 gcc cgt tat gcg ctg atc gct gaa atc att tcc aaa ctc gcc tcc cac 1680 Ala Arg Tyr Ala Leu Ile Ala Glu Ile Ile Ser Lys Leu Ala Ser His 545 550 555 560 gac tcc gcc gac gcc cgc tgg cgc aac acc gtt cta gac acc cgc cgc 1728 Asp Ser Ala Asp Ala Arg Trp Arg Asn Thr Val Leu Asp Thr Arg Arg                 565 570 575 cac gtt cgc ttc atc ggc ctc gag cgc gat tcc gac ggc gca acc gtc 1776 His Val Arg Phe Ile Gly Leu Glu Arg Asp Ser Asp Gly Ala Thr Val             580 585 590 aac acc tac gtc gac tcc gca tca ctt tca ggc gga caa gcc cag aag 1824 Asn Thr Tyr Val Asp Ser Ala Ser Leu Ser Gly Gly Gln Ala Gln Lys         595 600 605 ctg gtg ttt ttc tgc ctc gcc gct gcc ttg cgc tac cag cta gcc gaa 1872 Leu Val Phe Phe Cys Leu Ala Ala Ala Leu Arg Tyr Gln Leu Ala Glu     610 615 620 ccc ggc gcc cat tat ccc acc tac gcc acc gtc att ctg gac gaa gcc 1920 Pro Gly Ala His Tyr Pro Thr Tyr Ala Thr Val Ile Leu Asp Glu Ala 625 630 635 640 ttc gac cgc gcc gac ccc gcc ttc acc cgc caa acc atg aac gtc ttc 1968 Phe Asp Arg Ala Asp Pro Ala Phe Thr Arg Gln Thr Met Asn Val Phe                 645 650 655 cac agc ttc ggc ttc cac atg gtg ctc gcg acc ccg ctg aaa ctt atc 2016 His Ser Phe Gly Phe His Met Val Leu Ala Thr Pro Leu Lys Leu Ile             660 665 670 caa acc ctc ggc gat tat gtc ggc tcc acc atc gtg gtc agc tac acc 2064 Gln Thr Leu Gly Asp Tyr Val Gly Ser Thr Ile Val Val Ser Tyr Thr         675 680 685 gaa aaa cca aac gcc cag ggc gca att cag ggc aat tcc agt ttc tct 2112 Glu Lys Pro Asn Ala Gln Gly Ala Ile Gln Gly Asn Ser Ser Phe Ser     690 695 700 agg atc gag aaa taacatgcca ttgtttatcg acg 2147 Arg Ile Glu Lys 705 <210> 314 <211> 708 <212> PRT <213> Corynebacterium glutamicum <400> 314 Ala Ala Arg Leu Thr Val Asp Glu Tyr Pro Ala Ala Arg Glu Ala Leu   1 5 10 15 Glu Ser Ala Gly Gln Arg Asn Val Glu Asp Arg Thr Arg Ala Val Asp              20 25 30 Glu Phe Lys Ala Ala Asp Gln Glu Leu Ser Ser Leu Ser Lys Gly Ser          35 40 45 Ser Asn Ile Glu Tyr Arg Leu Leu Gln Val Arg Glu Asn Leu Cys Gln      50 55 60 Asp Leu Gly Val Ser Pro Arg Asp Met Pro Phe Ala Gly Glu Leu Ile  65 70 75 80 Asp Pro Asn Asn Ala Glu Trp Glu Pro Val Val Gln Arg Ile Leu Gly                  85 90 95 Gly Phe Ala Ala Glu Met Leu Val Pro His Gly Leu Leu Pro Arg Val             100 105 110 Arg Asp Trp Val Asn Ala Lys His Leu Ala Ala Leu Leu Lys Phe Asn         115 120 125 Gly Val Val Thr Thr Gly Glu Tyr Lys Thr Ser Arg Phe Pro Ala Asp     130 135 140 Ser Leu Ile Arg Lys Val Asp Val Val Glu Ser Pro Phe Arg Asp Trp 145 150 155 160 Val Asn Gln Glu Leu Gly Lys Arg Phe Asn Ile Arg Cys Val Arg Thr                 165 170 175 Pro Glu Glu Leu Ser Ala Leu Gly Pro Arg Asp Gln Gly Val Thr Ile             180 185 190 Leu Gly Val Arg Lys Phe Ala Gln Gln Thr Gly Asp Pro Thr Thr Arg         195 200 205 Trp Glu Lys Asp Asp Arg Arg Lys Leu Gly Asp Arg Ser Thr Tyr Arg     210 215 220 Leu Gly Ser Thr Asn Asp Ala Lys Val Glu Thr Leu Arg Glu Thr Val 225 230 235 240 Lys Ala Gly Lys Ala Val Val Gln Ala Ala Asp Asn Arg Ile Ala Ala                 245 250 255 Asn Arg Ala Glu Leu Arg Glu Leu Glu Arg Gln Tyr Gln Ala Ser Gln             260 265 270 Glu Ile Leu Lys Val Ser Trp Ala Gln Ile Asp Val Glu Ser Ala Asp         275 280 285 Ala Ala Ile Ala Glu Leu Asp Arg Leu Leu Glu Glu Leu Asn Asn Thr     290 295 300 Pro Glu Ala Thr Glu Leu Ser Ala Arg His Glu Ala Ala Lys Gln Thr 305 310 315 320 Leu Ala Arg Val Ser Asp Leu Leu Val Ala Ala Gln Ser Glu Glu Thr                 325 330 335 Val Ala Ser Met Asn Leu Lys Arg Ala Glu Thr Glu Leu Lys Arg Leu             340 345 350 Glu Ser Leu Pro Val Ala Glu Val Ser Glu Glu Ile Ala Arg Glu Val         355 360 365 Glu Lys Leu Phe Leu Ala Asn Thr Arg Arg Val His Ala Ala Asn Val     370 375 380 Asp Glu Gln Thr Ile Ala Leu Arg Glu Asp Leu Asp Lys Gln Ile Asp 385 390 395 400 Ala Asn Glu Ala Glu Leu Arg Arg Cys Glu Asn Gln Ile Val Gly Ile                 405 410 415 Leu Arg Ser Tyr Ile Glu Thr Trp Pro Ala Asn Arg Ala Asp Leu Gln             420 425 430 Ala Glu Pro Glu Phe Val Gly Glu Ala Ile Asn Arg Leu Gly Glu Leu         435 440 445 Arg Ser Asp Arg Leu Ala Glu Phe Thr Ala Lys Phe Leu Gly Leu Met     450 455 460 Asn Glu Met Ser Thr Arg Asn Leu Gly Gln Ile Ser Arg Arg Leu Arg 465 470 475 480 Asp Ala Arg Arg Glu Ile Glu Glu Arg Ile Glu Pro Ile Asn Ala Ser                 485 490 495 Leu Ala Gln Ser Glu Phe Asn Glu Gly Arg Phe Leu His Ile Asp Ile             500 505 510 Arg Asp Gln Ser Gly Pro Ile Val Arg Glu Phe Gln Gln Lys Leu Asp         515 520 525 Ala Ala Thr Ser Gly Asp Leu Gly Thr Ser Thr Glu Lys Gln Ala Phe     530 535 540 Ala Arg Tyr Ala Leu Ile Ala Glu Ile Ile Ser Lys Leu Ala Ser His 545 550 555 560 Asp Ser Ala Asp Ala Arg Trp Arg Asn Thr Val Leu Asp Thr Arg Arg                 565 570 575 His Val Arg Phe Ile Gly Leu Glu Arg Asp Ser Asp Gly Ala Thr Val             580 585 590 Asn Thr Tyr Val Asp Ser Ala Ser Leu Ser Gly Gly Gln Ala Gln Lys         595 600 605 Leu Val Phe Phe Cys Leu Ala Ala Ala Leu Arg Tyr Gln Leu Ala Glu     610 615 620 Pro Gly Ala His Tyr Pro Thr Tyr Ala Thr Val Ile Leu Asp Glu Ala 625 630 635 640 Phe Asp Arg Ala Asp Pro Ala Phe Thr Arg Gln Thr Met Asn Val Phe                 645 650 655 His Ser Phe Gly Phe His Met Val Leu Ala Thr Pro Leu Lys Leu Ile             660 665 670 Gln Thr Leu Gly Asp Tyr Val Gly Ser Thr Ile Val Val Ser Tyr Thr         675 680 685 Glu Lys Pro Asn Ala Gln Gly Ala Ile Gln Gly Asn Ser Ser Phe Ser     690 695 700 Arg Ile Glu Lys 705 <210> 315 <211> 1152 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1129) <223> RXN02571 <400> 315 tggacaggcc ggggccgcgt acggtgttgg ttgaggtggt ggaggggcgc gtcgaaaagc 60 attgtcgctg gttgttgccg cttttggcag tcgggatggc gtg gtg gct cta act 115                                             Val Val Ala Leu Thr                                               1 5 caa atc gtc gga ccg tcc ggc tcc ggg ctc acg cgg gaa ttg gaa aaa 163 Gln Ile Val Gly Pro Ser Gly Ser Gly Leu Thr Arg Glu Leu Glu Lys                  10 15 20 cgc tac cgg gaa acg ccc gga gcg gtg atg ctg acc gcc gac ccg cgc 211 Arg Tyr Arg Glu Thr Pro Gly Ala Val Met Leu Thr Ala Asp Pro Arg              25 30 35 gcg cat atc acc tac ctg cgc gcg aca gtc gcc gag gag ctg gcc ttt 259 Ala His Ile Thr Tyr Leu Arg Ala Thr Val Ala Glu Glu Leu Ala Phe          40 45 50 ggg ctg gaa caa cgc ggc atc gta ccc gcg cag atg tgg gag cgc gtc 307 Gly Leu Glu Gln Arg Gly Ile Val Pro Ala Gln Met Trp Glu Arg Val      55 60 65 cga aac atc ggg ctc ggc ctc gag aat ctg cta gac cgc gca ccc gcg 355 Arg Asn Ile Gly Leu Gly Leu Glu Asn Leu Leu Asp Arg Ala Pro Ala  70 75 80 85 caa ctt tcc ggc ggg caa aca cgg cgg ctg gcg atc ggc acc gtc gcc 403 Gln Leu Ser Gly Gly Gln Thr Arg Arg Leu Ala Ile Gly Thr Val Ala                  90 95 100 atc tta gag gcg cca acg atg ctt ctc gac gac ccc ctc tcc ggt ctt 451 Ile Leu Glu Ala Pro Thr Met Leu Leu Asp Asp Pro Leu Ser Gly Leu             105 110 115 gat acc tcc tcg cga gcc caa ctc atc aca atg ttg gaa tca tat gag 499 Asp Thr Ser Ser Arg Ala Gln Leu Ile Thr Met Leu Glu Ser Tyr Glu         120 125 130 ggc gat gtc atc gtc gct gcg cac aag cgg tgg ctc gac gcg ccg act 547 Gly Asp Val Ile Val Ala Ala His Lys Arg Trp Leu Asp Ala Pro Thr     135 140 145 gtg tac tta ggg gat ttg gag gag ctg tcc ctg cct gcg cgg gtg gaa 595 Val Tyr Leu Gly Asp Leu Glu Glu Leu Ser Leu Pro Ala Arg Val Glu 150 155 160 165 ttt tcc ggt cca tcg cga acg ttt tca gcg att aca gga acc cgc gga 643 Phe Ser Gly Pro Ser Arg Thr Phe Ser Ala Ile Thr Gly Thr Arg Gly                 170 175 180 caa caa cgc cga cgc tgg tgg caa ttc aac gaa tcc caa cca cag ttt 691 Gln Gln Arg Arg Arg Trp Trp Gln Phe Asn Glu Ser Gln Pro Gln Phe             185 190 195 cag atc ggc ccc ctg gat att act gtt tct gca ggt caa gtg ctg tgg 739 Gln Ile Gly Pro Leu Asp Ile Thr Val Ser Ala Gly Gln Val Leu Trp         200 205 210 ttg cag ggt ccc aat ggt tca ggg aag tcc aca ctc ctg cgt ggt ctt 787 Leu Gln Gly Pro Asn Gly Ser Gly Lys Ser Thr Leu Leu Arg Gly Leu     215 220 225 gcc aat gaa ccc ggc act gaa ttg atg ctg caa aac cct agc gat caa 835 Ala Asn Glu Pro Gly Thr Glu Leu Met Leu Gln Asn Pro Ser Asp Gln 230 235 240 245 gtc att gac tcc act gtt gct aat tgg gtg cca ggc agt aac agt gaa 883 Val Ile Asp Ser Thr Val Ala Asn Trp Val Pro Gly Ser Asn Ser Glu                 250 255 260 gaa cat ccg ctg gat tta tcg caa cgc gaa ctc cgc ctt gcc caa tgc 931 Glu His Pro Leu Asp Leu Ser Gln Arg Glu Leu Arg Leu Ala Gln Cys             265 270 275 gac gca gcc ctg ggt aat aac ccg gaa gtt ttg ctt gct gat gaa ccc 979 Asp Ala Ala Leu Gly Asn Asn Pro Glu Val Leu Leu Ala Asp Glu Pro         280 285 290 gac gtc ggc ctt gat gtc ggc ggt cga aac gcc atc cac cag cgc ttt 1027 Asp Val Gly Leu Asp Val Gly Gly Arg Asn Ala Ile His Gln Arg Phe     295 300 305 gcg gat ttc tta ggg aat ggg gga gcg ctg atc ctg acc tgc cat gat 1075 Ala Asp Phe Leu Gly Asn Gly Gly Ala Leu Ile Leu Thr Cys His Asp 310 315 320 325 gaa acc ttc gtg gca gag gta gct gaa tac gcg ata gtg aag gaa atg 1123 Glu Thr Phe Val Ala Glu Val Ala Glu Tyr Ala Ile Val Lys Glu Met                 330 335 340 ggg ctc taggtttctt tggaccaaac cac 1152 Gly leu <210> 316 <211> 343 <212> PRT <213> Corynebacterium glutamicum <400> 316 Val Val Ala Leu Thr Gln Ile Val Gly Pro Ser Gly Ser Gly Leu Thr   1 5 10 15 Arg Glu Leu Glu Lys Arg Tyr Arg Glu Thr Pro Gly Ala Val Met Leu              20 25 30 Thr Ala Asp Pro Arg Ala His Ile Thr Tyr Leu Arg Ala Thr Val Ala          35 40 45 Glu Glu Leu Ala Phe Gly Leu Glu Gln Arg Gly Ile Val Pro Ala Gln      50 55 60 Met Trp Glu Arg Val Arg Asn Ile Gly Leu Gly Leu Glu Asn Leu Leu  65 70 75 80 Asp Arg Ala Pro Ala Gln Leu Ser Gly Gly Gln Thr Arg Arg Leu Ala                  85 90 95 Ile Gly Thr Val Ala Ile Leu Glu Ala Pro Thr Met Leu Leu Asp Asp             100 105 110 Pro Leu Ser Gly Leu Asp Thr Ser Ser Arg Ala Gln Leu Ile Thr Met         115 120 125 Leu Glu Ser Tyr Glu Gly Asp Val Ile Val Ala Ala His Lys Arg Trp     130 135 140 Leu Asp Ala Pro Thr Val Tyr Leu Gly Asp Leu Glu Glu Leu Ser Leu 145 150 155 160 Pro Ala Arg Val Glu Phe Ser Gly Pro Ser Arg Thr Phe Ser Ala Ile                 165 170 175 Thr Gly Thr Arg Gly Gln Gln Arg Arg Arg Trp Trp Gln Phe Asn Glu             180 185 190 Ser Gln Pro Gln Phe Gln Ile Gly Pro Leu Asp Ile Thr Val Ser Ala         195 200 205 Gly Gln Val Leu Trp Leu Gln Gly Pro Asn Gly Ser Gly Lys Ser Thr     210 215 220 Leu Leu Arg Gly Leu Ala Asn Glu Pro Gly Thr Glu Leu Met Leu Gln 225 230 235 240 Asn Pro Ser Asp Gln Val Ile Asp Ser Thr Val Ala Asn Trp Val Pro                 245 250 255 Gly Ser Asn Ser Glu Glu His Pro Leu Asp Leu Ser Gln Arg Glu Leu             260 265 270 Arg Leu Ala Gln Cys Asp Ala Ala Leu Gly Asn Asn Pro Glu Val Leu         275 280 285 Leu Ala Asp Glu Pro Asp Val Gly Leu Asp Val Gly Gly Arg Asn Ala     290 295 300 Ile His Gln Arg Phe Ala Asp Phe Leu Gly Asn Gly Gly Ala Leu Ile 305 310 315 320 Leu Thr Cys His Asp Glu Thr Phe Val Ala Glu Val Ala Glu Tyr Ala                 325 330 335 Ile Val Lys Glu Met Gly Leu             340 <210> 317 <211> 1152 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1129) <223> FRXA02571 <400> 317 tggacaggcc ggggccgcgt acggtgttgg ttgaggtggt ggaggggcgc gtcgaaaagc 60 attgtcgctg gttgttgccg cttttggcag tcgggatggc gtg gtg gct cta act 115                                             Val Val Ala Leu Thr                                               1 5 caa atc gtc gga ccg tcc ggc tcc ggg ctc acg cgg gaa ttg gaa aaa 163 Gln Ile Val Gly Pro Ser Gly Ser Gly Leu Thr Arg Glu Leu Glu Lys                  10 15 20 cgc tac cgg gaa acg ccc gga gcg gtg atg ctg acc gcc gac ccg cgc 211 Arg Tyr Arg Glu Thr Pro Gly Ala Val Met Leu Thr Ala Asp Pro Arg              25 30 35 gcg cat atc acc tac ctg cgc gcg aca gtc gcc gag gag ctg gcc ttt 259 Ala His Ile Thr Tyr Leu Arg Ala Thr Val Ala Glu Glu Leu Ala Phe          40 45 50 ggg ctg gaa caa cgc ggc atc gta ccc gcg cag atg tgg gag cgc gtc 307 Gly Leu Glu Gln Arg Gly Ile Val Pro Ala Gln Met Trp Glu Arg Val      55 60 65 cga aac atc ggg ctc ggc ctc gag aat ctg cta gac cgc gca ccc gcg 355 Arg Asn Ile Gly Leu Gly Leu Glu Asn Leu Leu Asp Arg Ala Pro Ala  70 75 80 85 caa ctt tcc ggc ggg caa aca cgg cgg ctg gcg atc ggc acc gtc gcc 403 Gln Leu Ser Gly Gly Gln Thr Arg Arg Leu Ala Ile Gly Thr Val Ala                  90 95 100 atc tta gag gcg cca acg atg ctt ctc gac gac ccc ctc tcc ggt ctt 451 Ile Leu Glu Ala Pro Thr Met Leu Leu Asp Asp Pro Leu Ser Gly Leu             105 110 115 gat acc tcc tcg cga gcc caa ctc atc aca atg ttg gaa tca tat gag 499 Asp Thr Ser Ser Arg Ala Gln Leu Ile Thr Met Leu Glu Ser Tyr Glu         120 125 130 ggc gat gtc atc gtc gct gcg cac aag cgg tgg ctc gac gcg ccg act 547 Gly Asp Val Ile Val Ala Ala His Lys Arg Trp Leu Asp Ala Pro Thr     135 140 145 gtg tac tta ggg gat ttg gag gag ctg tcc ctg cct gcg cgg gtg gaa 595 Val Tyr Leu Gly Asp Leu Glu Glu Leu Ser Leu Pro Ala Arg Val Glu 150 155 160 165 ttt tcc ggt cca tcg cga acg ttt tca gcg att aca gga acc cgc gga 643 Phe Ser Gly Pro Ser Arg Thr Phe Ser Ala Ile Thr Gly Thr Arg Gly                 170 175 180 caa caa cgc cga cgc tgg tgg caa ttc aac gaa tcc caa cca cag ttt 691 Gln Gln Arg Arg Arg Trp Trp Gln Phe Asn Glu Ser Gln Pro Gln Phe             185 190 195 cag atc ggc ccc ctg gat att act gtt tct gca ggt caa gtg ctg tgg 739 Gln Ile Gly Pro Leu Asp Ile Thr Val Ser Ala Gly Gln Val Leu Trp         200 205 210 ttg cag ggt ccc aat ggt tca ggg aag tcc aca ctc ctg cgt ggt ctt 787 Leu Gln Gly Pro Asn Gly Ser Gly Lys Ser Thr Leu Leu Arg Gly Leu     215 220 225 gcc aat gaa ccc ggc act gaa ttg atg ctg caa aac cct agc gat caa 835 Ala Asn Glu Pro Gly Thr Glu Leu Met Leu Gln Asn Pro Ser Asp Gln 230 235 240 245 gtc att gac tcc act gtt gct aat tgg gtg cca ggc agt aac agt gaa 883 Val Ile Asp Ser Thr Val Ala Asn Trp Val Pro Gly Ser Asn Ser Glu                 250 255 260 gaa cat ccg ctg gat tta tcg caa cgc gaa ctc cgc ctt gcc caa tgc 931 Glu His Pro Leu Asp Leu Ser Gln Arg Glu Leu Arg Leu Ala Gln Cys             265 270 275 gac gca gcc ctg ggt aat aac ccg gaa gtt ttg ctt gct gat gaa ccc 979 Asp Ala Ala Leu Gly Asn Asn Pro Glu Val Leu Leu Ala Asp Glu Pro         280 285 290 gac gtc ggc ctt gat gtc ggc ggt cga aac gcc atc cac cag cgc ttt 1027 Asp Val Gly Leu Asp Val Gly Gly Arg Asn Ala Ile His Gln Arg Phe     295 300 305 gcg gat ttc tta ggg aat ggg gga gcg ctg atc ctg acc tgc cat gat 1075 Ala Asp Phe Leu Gly Asn Gly Gly Ala Leu Ile Leu Thr Cys His Asp 310 315 320 325 gaa acc ttc gtg gca gag gta gct gaa tac gcg ata gtg aag gaa atg 1123 Glu Thr Phe Val Ala Glu Val Ala Glu Tyr Ala Ile Val Lys Glu Met                 330 335 340 ggg ctc taggtttctt tggaccaaac cac 1152 Gly leu <210> 318 <211> 343 <212> PRT <213> Corynebacterium glutamicum <400> 318 Val Val Ala Leu Thr Gln Ile Val Gly Pro Ser Gly Ser Gly Leu Thr   1 5 10 15 Arg Glu Leu Glu Lys Arg Tyr Arg Glu Thr Pro Gly Ala Val Met Leu              20 25 30 Thr Ala Asp Pro Arg Ala His Ile Thr Tyr Leu Arg Ala Thr Val Ala          35 40 45 Glu Glu Leu Ala Phe Gly Leu Glu Gln Arg Gly Ile Val Pro Ala Gln      50 55 60 Met Trp Glu Arg Val Arg Asn Ile Gly Leu Gly Leu Glu Asn Leu Leu  65 70 75 80 Asp Arg Ala Pro Ala Gln Leu Ser Gly Gly Gln Thr Arg Arg Leu Ala                  85 90 95 Ile Gly Thr Val Ala Ile Leu Glu Ala Pro Thr Met Leu Leu Asp Asp             100 105 110 Pro Leu Ser Gly Leu Asp Thr Ser Ser Arg Ala Gln Leu Ile Thr Met         115 120 125 Leu Glu Ser Tyr Glu Gly Asp Val Ile Val Ala Ala His Lys Arg Trp     130 135 140 Leu Asp Ala Pro Thr Val Tyr Leu Gly Asp Leu Glu Glu Leu Ser Leu 145 150 155 160 Pro Ala Arg Val Glu Phe Ser Gly Pro Ser Arg Thr Phe Ser Ala Ile                 165 170 175 Thr Gly Thr Arg Gly Gln Gln Arg Arg Arg Trp Trp Gln Phe Asn Glu             180 185 190 Ser Gln Pro Gln Phe Gln Ile Gly Pro Leu Asp Ile Thr Val Ser Ala         195 200 205 Gly Gln Val Leu Trp Leu Gln Gly Pro Asn Gly Ser Gly Lys Ser Thr     210 215 220 Leu Leu Arg Gly Leu Ala Asn Glu Pro Gly Thr Glu Leu Met Leu Gln 225 230 235 240 Asn Pro Ser Asp Gln Val Ile Asp Ser Thr Val Ala Asn Trp Val Pro                 245 250 255 Gly Ser Asn Ser Glu Glu His Pro Leu Asp Leu Ser Gln Arg Glu Leu             260 265 270 Arg Leu Ala Gln Cys Asp Ala Ala Leu Gly Asn Asn Pro Glu Val Leu         275 280 285 Leu Ala Asp Glu Pro Asp Val Gly Leu Asp Val Gly Gly Arg Asn Ala     290 295 300 Ile His Gln Arg Phe Ala Asp Phe Leu Gly Asn Gly Gly Ala Leu Ile 305 310 315 320 Leu Thr Cys His Asp Glu Thr Phe Val Ala Glu Val Ala Glu Tyr Ala                 325 330 335 Ile Val Lys Glu Met Gly Leu             340 <210> 319 <211> 1746 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1723) <223> RXN02074 <400> 319 cgggggaagg ccgtgtcgca tgctcgggct agccttggat ctcaagaaga attcgactgg 60 tttaaagtct gggctttaag tgcagaaagg ttgtggattg atg cgc tcc ctg ctt 115                                             Met Arg Ser Leu Leu                                               1 5 cgt gat atc cct gcg gtg ggt tgg cta atc acc gcg acg att gtt gtg 163 Arg Asp Ile Pro Ala Val Gly Trp Leu Ile Thr Ala Thr Ile Val Val                  10 15 20 cgc acg ctc gtt gtt gcg ctg gtc atc gtt ggg atc ggc ttg ctt atc 211 Arg Thr Leu Val Val Ala Leu Val Ile Val Gly Ile Gly Leu Leu Ile              25 30 35 gac gtc ccc tcg ccc gct cat tca gcc atg ttg tgg tgg gtt ctg gca 259 Asp Val Pro Ser Pro Ala His Ser Ala Met Leu Trp Trp Val Leu Ala          40 45 50 ggt gcc acg gca gca gct gcg ctg ctg tgc gcg gaa gcg gtg ctc ccc 307 Gly Ala Thr Ala Ala Ala Ala Leu Leu Cys Ala Glu Ala Val Leu Pro      55 60 65 caa cgt att cgt gca cga gtt gaa cga tcc tgg cgg cgg cag ttg gct 355 Gln Arg Ile Arg Ala Arg Val Glu Arg Ser Trp Arg Arg Gln Leu Ala  70 75 80 85 gct aaa aat ctg gag ctg aat tcc agt tcg tca gat gat gcc cag ttg 403 Ala Lys Asn Leu Glu Leu Asn Ser Ser Ser Ser Asp Asp Ala Gln Leu                  90 95 100 atc aca ctg gca act gaa gcc acc tca aaa gca tcc act tac aca gtg 451 Ile Thr Leu Ala Thr Glu Ala Thr Ser Lys Ala Ser Thr Tyr Thr Val             105 110 115 atg ttt ctg ggg cct tac ttt gca gta ttt ttg gcc cca ctg aca gtt 499 Met Phe Leu Gly Pro Tyr Phe Ala Val Phe Leu Ala Pro Leu Thr Val         120 125 130 att gcc gtt gtc ggc gcg gct att tcc tgg ccg att gcg ggg ata ctg 547 Ile Ala Val Val Gly Ala Ala Ile Ser Trp Pro Ile Ala Gly Ile Leu     135 140 145 tgc ctc ggg ttg tgc gtg ata cct ttc gtt att tct tgg gca cag cgc 595 Cys Leu Gly Leu Cys Val Ile Pro Phe Val Ile Ser Trp Ala Gln Arg 150 155 160 165 atg ttg aaa ggc gct ggc gcg gga tac ggg cga gca tct ggg cag ttg 643 Met Leu Lys Gly Ala Gly Ala Gly Tyr Gly Arg Ala Ser Gly Gln Leu                 170 175 180 gca ggc gtg ttt ttg gaa tcg gtg cgc aca cta ggc acc acg atg atg 691 Ala Gly Val Phe Leu Glu Ser Val Arg Thr Leu Gly Thr Thr Met Met             185 190 195 ctg aat gcc gct ggg cag cgc agg cag atc atc aca cag cgc gca gag 739 Leu Asn Ala Ala Gly Gln Arg Arg Gln Ile Ile Thr Gln Arg Ala Glu         200 205 210 aat atg cgc tcc caa gtg atg tca ttg ctg tac cga aat cag ttg atg 787 Asn Met Arg Ser Gln Val Met Ser Leu Leu Tyr Arg Asn Gln Leu Met     215 220 225 att ctg gtg acc gac ggc gtg ttt gga gtt gcc acc aca atg gtt gct 835 Ile Leu Val Thr Asp Gly Val Phe Gly Val Ala Thr Thr Met Val Ala 230 235 240 245 gcg gtg ttt gcc att gga gga ttc ttt tca ggc tct ctt act ctc ggc 883 Ala Val Phe Ala Ile Gly Gly Phe Phe Ser Gly Ser Leu Thr Leu Gly                 250 255 260 caa gct gta gca ctc gta ttg ctg gcc agg ctg ctt att gat ccc atc 931 Gln Ala Val Ala Leu Val Leu Leu Ala Arg Leu Leu Ile Asp Pro Ile             265 270 275 aac cgc atg ggt cgc acg ttt tac acc ggc atg gca ggc aaa ccc tcg 979 Asn Arg Met Gly Arg Thr Phe Tyr Thr Gly Met Ala Gly Lys Pro Ser         280 285 290 ctg atc gcc att gaa aaa gcc ctc gcg aca acc ttt act gat cag cca 1027 Leu Ile Ala Ile Glu Lys Ala Leu Ala Thr Thr Phe Thr Asp Gln Pro     295 300 305 act caa cag gga cag cgc cac gat ggg gat ctg gtg gtc aac aac ttg 1075 Thr Gln Gln Gly Gln Arg His Asp Gly Asp Leu Val Val Asn Asn Leu 310 315 320 325 aag atc gcc cgc gat cac agg gac att gtg cac ggt atc tct ttc agc 1123 Lys Ile Ala Arg Asp His Arg Asp Ile Val His Gly Ile Ser Phe Ser                 330 335 340 att ccc cgc ggt tcc cac atc gcg gtg gta ggt ccc agt ggc gct ggt 1171 Ile Pro Arg Gly Ser His Ile Ala Val Val Gly Pro Ser Gly Ala Gly             345 350 355 aaa tcc tct gtg gct cta gcg ttg tcc gga ctt tta gag ttt gat ggt 1219 Lys Ser Ser Val Ala Leu Ala Leu Ser Gly Leu Leu Glu Phe Asp Gly         360 365 370 gcg att tcc ctc ggc ggc cac aac tgt gag atg tta gat ctt cgc gcc 1267 Ala Ile Ser Leu Gly Gly His Asn Cys Glu Met Leu Asp Leu Arg Ala     375 380 385 tca gtc agt ttc gtg ccc caa tcc ccc acg ctg ttt agc gga agc atc 1315 Ser Val Ser Phe Val Pro Gln Ser Pro Thr Leu Phe Ser Gly Ser Ile 390 395 400 405 aaa agc aat atc gat ctg gcg cgc acg ggt gtt gat tct gat cac atc 1363 Lys Ser Asn Ile Asp Leu Ala Arg Thr Gly Val Asp Ser Asp His Ile                 410 415 420 cac gca gca ctt tta ggc gaa gaa ctc ccc gcg gac ctc aaa gtc ggt 1411 His Ala Ala Leu Leu Gly Glu Glu Leu Pro Ala Asp Leu Lys Val Gly             425 430 435 gaa acc ggc aaa ggt gtc tcc ggc ggc caa gca gca cgc att tcc att 1459 Glu Thr Gly Lys Gly Val Ser Gly Gly Gln Ala Ala Arg Ile Ser Ile         440 445 450 gcc cga ggt tta gta aag aat gct gcc gtg att gtt ctc gac gag gcg 1507 Ala Arg Gly Leu Val Lys Asn Ala Ala Val Ile Val Leu Asp Glu Ala     455 460 465 acc gca caa ctc gac tac acc aac gcc cgc cag gtt cga cat ctt gcc 1555 Thr Ala Gln Leu Asp Tyr Thr Asn Ala Arg Gln Val Arg His Leu Ala 470 475 480 485 aaa tcc ctt gag tgc acg ttg gtt gag atc acc cac cgc cca tca gaa 1603 Lys Ser Leu Glu Cys Thr Leu Val Glu Ile Thr His Arg Pro Ser Glu                 490 495 500 gcc ctc gat gca gac ttc atc att gtt tta gag gat ggc caa ttg acc 1651 Ala Leu Asp Ala Asp Phe Ile Ile Val Leu Glu Asp Gly Gln Leu Thr             505 510 515 atg atg gat aca ccc agc aac gtt tcc cag cac aat gcg ttt ttc cgc 1699 Met Met Asp Thr Pro Ser Asn Val Ser Gln His Asn Ala Phe Phe Arg         520 525 530 acc gct gtg atg gag gaa gaa caa tgatttcccg acttctccaa ttg 1746 Thr Ala Val Met Glu Glu Glu Gln     535 540 <210> 320 <211> 541 <212> PRT <213> Corynebacterium glutamicum <400> 320 Met Arg Ser Leu Leu Arg Asp Ile Pro Ala Val Gly Trp Leu Ile Thr   1 5 10 15 Ala Thr Ile Val Val Arg Thr Leu Val Val Ala Leu Val Ile Val Gly              20 25 30 Ile Gly Leu Leu Ile Asp Val Pro Ser Pro Ala His Ser Ala Met Leu          35 40 45 Trp Trp Val Leu Ala Gly Ala Thr Ala Ala Ala Ala Leu Leu Cys Ala      50 55 60 Glu Ala Val Leu Pro Gln Arg Ile Arg Ala Arg Val Glu Arg Ser Trp  65 70 75 80 Arg Arg Gln Leu Ala Ala Lys Asn Leu Glu Leu Asn Ser Ser Ser Ser                  85 90 95 Asp Asp Ala Gln Leu Ile Thr Leu Ala Thr Glu Ala Thr Ser Lys Ala             100 105 110 Ser Thr Tyr Thr Val Met Phe Leu Gly Pro Tyr Phe Ala Val Phe Leu         115 120 125 Ala Pro Leu Thr Val Ile Ala Val Val Gly Ala Ala Ile Ser Trp Pro     130 135 140 Ile Ala Gly Ile Leu Cys Leu Gly Leu Cys Val Ile Pro Phe Val Ile 145 150 155 160 Ser Trp Ala Gln Arg Met Leu Lys Gly Ala Gly Ala Gly Tyr Gly Arg                 165 170 175 Ala Ser Gly Gln Leu Ala Gly Val Phe Leu Glu Ser Val Arg Thr Leu             180 185 190 Gly Thr Thr Met Met Leu Asn Ala Ala Gly Gln Arg Arg Gln Ile Ile         195 200 205 Thr Gln Arg Ala Glu Asn Met Arg Ser Gln Val Met Ser Leu Leu Tyr     210 215 220 Arg Asn Gln Leu Met Ile Leu Val Thr Asp Gly Val Phe Gly Val Ala 225 230 235 240 Thr Thr Met Val Ala Ala Val Phe Ala Ile Gly Gly Phe Phe Ser Gly                 245 250 255 Ser Leu Thr Leu Gly Gln Ala Val Ala Leu Val Leu Leu Ala Arg Leu             260 265 270 Leu Ile Asp Pro Ile Asn Arg Met Gly Arg Thr Phe Tyr Thr Gly Met         275 280 285 Ala Gly Lys Pro Ser Leu Ile Ala Ile Glu Lys Ala Leu Ala Thr Thr     290 295 300 Phe Thr Asp Gln Pro Thr Gln Gln Gly Gln Arg His Asp Gly Asp Leu 305 310 315 320 Val Val Asn Asn Leu Lys Ile Ala Arg Asp His Arg Asp Ile Val His                 325 330 335 Gly Ile Ser Phe Ser Ile Pro Arg Gly Ser His Ile Ala Val Val Gly             340 345 350 Pro Ser Gly Ala Gly Lys Ser Ser Val Ala Leu Ala Leu Ser Gly Leu         355 360 365 Leu Glu Phe Asp Gly Ala Ile Ser Leu Gly Gly His Asn Cys Glu Met     370 375 380 Leu Asp Leu Arg Ala Ser Val Ser Phe Val Pro Gln Ser Pro Thr Leu 385 390 395 400 Phe Ser Gly Ser Ile Lys Ser Asn Ile Asp Leu Ala Arg Thr Gly Val                 405 410 415 Asp Ser Asp His Ile His Ala Ala Leu Leu Gly Glu Glu Leu Pro Ala             420 425 430 Asp Leu Lys Val Gly Glu Thr Gly Lys Gly Val Ser Gly Gly Gln Ala         435 440 445 Ala Arg Ile Ser Ile Ala Arg Gly Leu Val Lys Asn Ala Ala Val Ile     450 455 460 Val Leu Asp Glu Ala Thr Ala Gln Leu Asp Tyr Thr Asn Ala Arg Gln 465 470 475 480 Val Arg His Leu Ala Lys Ser Leu Glu Cys Thr Leu Val Glu Ile Thr                 485 490 495 His Arg Pro Ser Glu Ala Leu Asp Ala Asp Phe Ile Val Leu Glu             500 505 510 Asp Gly Gln Leu Thr Met Met Asp Thr Pro Ser Asn Val Ser Gln His         515 520 525 Asn Ala Phe Phe Arg Thr Ala Val Met Glu Glu Glu Gln     530 535 540 <210> 321 <211> 1746 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1723) <223> FRXA02074 <400> 321 cgggggaagg ccgtgtcgca tgctcgggct agccttggat ctcaagaaga attcgactgg 60 tttaaagtct gggctttaag tgcagaaagg ttgtggattg atg cgc tcc ctg ctt 115                                             Met Arg Ser Leu Leu                                               1 5 cgt gat atc cct gcg gtg ggt tgg cta atc acc gcg acg att gtt gtg 163 Arg Asp Ile Pro Ala Val Gly Trp Leu Ile Thr Ala Thr Ile Val Val                  10 15 20 cgc acg ctc gtt gtt gcg ctg gtc atc gtt ggg atc ggc ttg ctt atc 211 Arg Thr Leu Val Val Ala Leu Val Ile Val Gly Ile Gly Leu Leu Ile              25 30 35 gac gtc ccc tcg ccc gct cat tca gcc atg ttg tgg tgg gtt ctg gca 259 Asp Val Pro Ser Pro Ala His Ser Ala Met Leu Trp Trp Val Leu Ala          40 45 50 ggt gcc acg gca gca gct gcg ctg ctg tgc gcg gaa gcg gtg ctc ccc 307 Gly Ala Thr Ala Ala Ala Ala Leu Leu Cys Ala Glu Ala Val Leu Pro      55 60 65 caa cgt att cgt gca cga gtt gaa cga tcc tgg cgg cgg cag ttg gct 355 Gln Arg Ile Arg Ala Arg Val Glu Arg Ser Trp Arg Arg Gln Leu Ala  70 75 80 85 gct aaa aat ctg gag ctg aat tcc agt tcg tca gat gat gcc cag ttg 403 Ala Lys Asn Leu Glu Leu Asn Ser Ser Ser Ser Asp Asp Ala Gln Leu                  90 95 100 atc aca ctg gca act gaa gcc acc tca aaa gca tcc act tac aca gtg 451 Ile Thr Leu Ala Thr Glu Ala Thr Ser Lys Ala Ser Thr Tyr Thr Val             105 110 115 atg ttt ctg ggg cct tac ttt gca gta ttt ttg gcc cca ctg aca gtt 499 Met Phe Leu Gly Pro Tyr Phe Ala Val Phe Leu Ala Pro Leu Thr Val         120 125 130 att gcc gtt gtc ggc gcg gct att tcc tgg ccg att gcg ggg ata ctg 547 Ile Ala Val Val Gly Ala Ala Ile Ser Trp Pro Ile Ala Gly Ile Leu     135 140 145 tgc ctc ggg ttg tgc gtg ata cct ttc gtt att tct tgg gca cag cgc 595 Cys Leu Gly Leu Cys Val Ile Pro Phe Val Ile Ser Trp Ala Gln Arg 150 155 160 165 atg ttg aaa ggc gct ggc gcg gga tac ggg cga gca tct ggg cag ttg 643 Met Leu Lys Gly Ala Gly Ala Gly Tyr Gly Arg Ala Ser Gly Gln Leu                 170 175 180 gca ggc gtg ttt ttg gaa tcg gtg cgc aca cta ggc acc acg atg atg 691 Ala Gly Val Phe Leu Glu Ser Val Arg Thr Leu Gly Thr Thr Met Met             185 190 195 ctg aat gcc gct ggg cag cgc agg cag atc atc aca cag cgc gca gag 739 Leu Asn Ala Ala Gly Gln Arg Arg Gln Ile Ile Thr Gln Arg Ala Glu         200 205 210 aat atg cgc tcc caa gtg atg tca ttg ctg tac cga aat cag ttg atg 787 Asn Met Arg Ser Gln Val Met Ser Leu Leu Tyr Arg Asn Gln Leu Met     215 220 225 att ctg gtg acc gac ggc gtg ttt gga gtt gcc acc aca atg gtt gct 835 Ile Leu Val Thr Asp Gly Val Phe Gly Val Ala Thr Thr Met Val Ala 230 235 240 245 gcg gtg ttt gcc att gga gga ttc ttt tca ggc tct ctt act ctc ggc 883 Ala Val Phe Ala Ile Gly Gly Phe Phe Ser Gly Ser Leu Thr Leu Gly                 250 255 260 caa gct gta gca ctc gta ttg ctg gcc agg ctg ctt att gat ccc atc 931 Gln Ala Val Ala Leu Val Leu Leu Ala Arg Leu Leu Ile Asp Pro Ile             265 270 275 aac cgc atg ggt cgc acg ttt tac acc ggc atg gca ggc aaa ccc tcg 979 Asn Arg Met Gly Arg Thr Phe Tyr Thr Gly Met Ala Gly Lys Pro Ser         280 285 290 ctg atc gcc att gaa aaa gcc ctc gcg aca acc ttt act gat cag cca 1027 Leu Ile Ala Ile Glu Lys Ala Leu Ala Thr Thr Phe Thr Asp Gln Pro     295 300 305 act caa cag gga cag cgc cac gat ggg gat ctg gtg gtc aac aac ttg 1075 Thr Gln Gln Gly Gln Arg His Asp Gly Asp Leu Val Val Asn Asn Leu 310 315 320 325 aag atc gcc cgc gat cac agg gac att gtg cac ggt atc tct ttc agc 1123 Lys Ile Ala Arg Asp His Arg Asp Ile Val His Gly Ile Ser Phe Ser                 330 335 340 att ccc cgc ggt tcc cac atc gcg gtg gta ggt ccc agt ggc gct ggt 1171 Ile Pro Arg Gly Ser His Ile Ala Val Val Gly Pro Ser Gly Ala Gly             345 350 355 aaa tcc tct gtg gct cta gcg ttg tcc gga ctt tta gag ttt gat ggt 1219 Lys Ser Ser Val Ala Leu Ala Leu Ser Gly Leu Leu Glu Phe Asp Gly         360 365 370 gcg att tcc ctc ggc ggc cac aac tgt gag atg tta gat ctt cgc gcc 1267 Ala Ile Ser Leu Gly Gly His Asn Cys Glu Met Leu Asp Leu Arg Ala     375 380 385 tca gtc agt ttc gtg ccc caa tcc ccc acg ctg ttt agc gga agc atc 1315 Ser Val Ser Phe Val Pro Gln Ser Pro Thr Leu Phe Ser Gly Ser Ile 390 395 400 405 aaa agc aat atc gat ctg gcg cgc acg ggt gtt gat tct gat cac atc 1363 Lys Ser Asn Ile Asp Leu Ala Arg Thr Gly Val Asp Ser Asp His Ile                 410 415 420 cac gca gca ctt tta ggc gaa gaa ctc ccc gcg gac ctc aaa gtc ggt 1411 His Ala Ala Leu Leu Gly Glu Glu Leu Pro Ala Asp Leu Lys Val Gly             425 430 435 gaa acc ggc aaa ggt gtc tcc ggc ggc caa gca gca cgc att tcc att 1459 Glu Thr Gly Lys Gly Val Ser Gly Gly Gln Ala Ala Arg Ile Ser Ile         440 445 450 gcc cga ggt tta gta aag aat gct gcc gtg att gtt ctc gac gag gcg 1507 Ala Arg Gly Leu Val Lys Asn Ala Ala Val Ile Val Leu Asp Glu Ala     455 460 465 acc gca caa ctc gac tac acc aac gcc cgc cag gtt cga cat ctt gcc 1555 Thr Ala Gln Leu Asp Tyr Thr Asn Ala Arg Gln Val Arg His Leu Ala 470 475 480 485 aaa tcc ctt gag tgc acg ttg gtt gag atc acc cac cgc cca tca gaa 1603 Lys Ser Leu Glu Cys Thr Leu Val Glu Ile Thr His Arg Pro Ser Glu                 490 495 500 gcc ctc gat gca gac ttc atc att gtt tta gag gat ggc caa ttg acc 1651 Ala Leu Asp Ala Asp Phe Ile Ile Val Leu Glu Asp Gly Gln Leu Thr             505 510 515 atg atg gat aca ccc agc aac gtt tcc cag cac aat gcg ttt ttc cgc 1699 Met Met Asp Thr Pro Ser Asn Val Ser Gln His Asn Ala Phe Phe Arg         520 525 530 acc gct gtg atg gag gaa gaa caa tgatttcccg acttctccaa ttg 1746 Thr Ala Val Met Glu Glu Glu Gln     535 540 <210> 322 <211> 541 <212> PRT <213> Corynebacterium glutamicum <400> 322 Met Arg Ser Leu Leu Arg Asp Ile Pro Ala Val Gly Trp Leu Ile Thr   1 5 10 15 Ala Thr Ile Val Val Arg Thr Leu Val Val Ala Leu Val Ile Val Gly              20 25 30 Ile Gly Leu Leu Ile Asp Val Pro Ser Pro Ala His Ser Ala Met Leu          35 40 45 Trp Trp Val Leu Ala Gly Ala Thr Ala Ala Ala Ala Leu Leu Cys Ala      50 55 60 Glu Ala Val Leu Pro Gln Arg Ile Arg Ala Arg Val Glu Arg Ser Trp  65 70 75 80 Arg Arg Gln Leu Ala Ala Lys Asn Leu Glu Leu Asn Ser Ser Ser Ser                  85 90 95 Asp Asp Ala Gln Leu Ile Thr Leu Ala Thr Glu Ala Thr Ser Lys Ala             100 105 110 Ser Thr Tyr Thr Val Met Phe Leu Gly Pro Tyr Phe Ala Val Phe Leu         115 120 125 Ala Pro Leu Thr Val Ile Ala Val Val Gly Ala Ala Ile Ser Trp Pro     130 135 140 Ile Ala Gly Ile Leu Cys Leu Gly Leu Cys Val Ile Pro Phe Val Ile 145 150 155 160 Ser Trp Ala Gln Arg Met Leu Lys Gly Ala Gly Ala Gly Tyr Gly Arg                 165 170 175 Ala Ser Gly Gln Leu Ala Gly Val Phe Leu Glu Ser Val Arg Thr Leu             180 185 190 Gly Thr Thr Met Met Leu Asn Ala Ala Gly Gln Arg Arg Gln Ile Ile         195 200 205 Thr Gln Arg Ala Glu Asn Met Arg Ser Gln Val Met Ser Leu Leu Tyr     210 215 220 Arg Asn Gln Leu Met Ile Leu Val Thr Asp Gly Val Phe Gly Val Ala 225 230 235 240 Thr Thr Met Val Ala Ala Val Phe Ala Ile Gly Gly Phe Phe Ser Gly                 245 250 255 Ser Leu Thr Leu Gly Gln Ala Val Ala Leu Val Leu Leu Ala Arg Leu             260 265 270 Leu Ile Asp Pro Ile Asn Arg Met Gly Arg Thr Phe Tyr Thr Gly Met         275 280 285 Ala Gly Lys Pro Ser Leu Ile Ala Ile Glu Lys Ala Leu Ala Thr Thr     290 295 300 Phe Thr Asp Gln Pro Thr Gln Gln Gly Gln Arg His Asp Gly Asp Leu 305 310 315 320 Val Val Asn Asn Leu Lys Ile Ala Arg Asp His Arg Asp Ile Val His                 325 330 335 Gly Ile Ser Phe Ser Ile Pro Arg Gly Ser His Ile Ala Val Val Gly             340 345 350 Pro Ser Gly Ala Gly Lys Ser Ser Val Ala Leu Ala Leu Ser Gly Leu         355 360 365 Leu Glu Phe Asp Gly Ala Ile Ser Leu Gly Gly His Asn Cys Glu Met     370 375 380 Leu Asp Leu Arg Ala Ser Val Ser Phe Val Pro Gln Ser Pro Thr Leu 385 390 395 400 Phe Ser Gly Ser Ile Lys Ser Asn Ile Asp Leu Ala Arg Thr Gly Val                 405 410 415 Asp Ser Asp His Ile His Ala Ala Leu Leu Gly Glu Glu Leu Pro Ala             420 425 430 Asp Leu Lys Val Gly Glu Thr Gly Lys Gly Val Ser Gly Gly Gln Ala         435 440 445 Ala Arg Ile Ser Ile Ala Arg Gly Leu Val Lys Asn Ala Ala Val Ile     450 455 460 Val Leu Asp Glu Ala Thr Ala Gln Leu Asp Tyr Thr Asn Ala Arg Gln 465 470 475 480 Val Arg His Leu Ala Lys Ser Leu Glu Cys Thr Leu Val Glu Ile Thr                 485 490 495 His Arg Pro Ser Glu Ala Leu Asp Ala Asp Phe Ile Val Leu Glu             500 505 510 Asp Gly Gln Leu Thr Met Met Asp Thr Pro Ser Asn Val Ser Gln His         515 520 525 Asn Ala Phe Phe Arg Thr Ala Val Met Glu Glu Glu Gln     530 535 540 <210> 323 <211> 1527 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1504) <223> RXA02095 <400> 323 ctctcttggt cctctcccca cccattttta agtactcaag acccttccaa cagaaaggat 60 tactccccca acaggctcaa aaatactgaa aggctcacgc atg aaa act gag caa 115                                             Met Lys Thr Glu Gln                                               1 5 tcc caa aaa gca caa tta gcc cct aag aaa gca cct gaa aag cca caa 163 Ser Gln Lys Ala Gln Leu Ala Pro Lys Lys Ala Pro Glu Lys Pro Gln                  10 15 20 cgc atc cgc caa ctt att tcc gtg gcg tgg cag cga cct tgg ctc acc 211 Arg Ile Arg Gln Leu Ile Ser Val Ala Trp Gln Arg Pro Trp Leu Thr              25 30 35 tca ttc acc gta atc agc gct tta gct gca acg ttg ttt gaa ctt aca 259 Ser Phe Thr Val Ile Ser Ala Leu Ala Ala Thr Leu Phe Glu Leu Thr          40 45 50 ctt cct ctt ttg acc ggt ggc gcc atc gat atc gcg ctc gga aat acc 307 Leu Pro Leu Leu Thr Gly Gly Ala Ile Asp Ile Ala Leu Gly Asn Thr      55 60 65 gga gat act tta acc act gac ctg ctg gac cgg ttc act ccg agt gga 355 Gly Asp Thr Leu Thr Thr Asp Leu Leu Asp Arg Phe Thr Pro Ser Gly  70 75 80 85 tta agc gtg ttg acc agc gtc att gcc ctt atc gtg ctt ctc gcg ttg 403 Leu Ser Val Leu Thr Ser Val Ile Ala Leu Ile Val Leu Leu Ala Leu                  90 95 100 ctt cgc tat gcc agt caa ttt gga cgg cga tac acc gca ggc aag ctc 451 Leu Arg Tyr Ala Ser Gln Phe Gly Arg Arg Tyr Thr Ala Gly Lys Leu             105 110 115 agc atg ggg gta cag cat gat gtc cgg ctt aaa acg atg cgc tca ttg 499 Ser Met Gly Val Gln His Asp Val Arg Leu Lys Thr Met Arg Ser Leu         120 125 130 cag aac ctc gat ggg cca ggt cag gac tct att cgc aca ggc caa gta 547 Gln Asn Leu Asp Gly Pro Gly Gln Asp Ser Ile Arg Thr Gly Gln Val     135 140 145 gtc agt cgg tcc att tcg gat atc aac atg gtg caa agc ctt gtg gcg 595 Val Ser Arg Ser Ile Ser Asp Ile Asn Met Val Gln Ser Leu Val Ala 150 155 160 165 atg ttg ccg atg ttg atc gga aat gtg gtc aag ctt gtg ctc act ttg 643 Met Leu Pro Met Leu Ile Gly Asn Val Val Lys Leu Val Leu Thr Leu                 170 175 180 gtg atc atg ctg gct att tcc ccg ccg ctg acc atc atc gct gca gtg 691 Val Ile Met Leu Ala Ile Ser Pro Pro Leu Thr Ile Ile Ala Ala Val             185 190 195 ttg gtg cct ttg ctg ttg tgg gcc gtg gcc tat tcg cga aaa gcg ctt 739 Leu Val Pro Leu Leu Leu Trp Ala Val Ala Tyr Ser Arg Lys Ala Leu         200 205 210 ttt gcg tcc acg tgg tcg gcc cag caa aag gct gcg gat ctg acc act 787 Phe Ala Ser Thr Trp Ser Ala Gln Gln Lys Ala Ala Asp Leu Thr Thr     215 220 225 cat gtg gaa gaa act gtc acg ggt atc cgc gtg gtc aag gca ttt gcg 835 His Val Glu Glu Thr Val Thr Gly Ile Arg Val Val Lys Ala Phe Ala 230 235 240 245 cag gaa gac cgc gag acc gac aaa ttg gat ctc acc gca cgt gag tta 883 Gln Glu Asp Arg Glu Thr Asp Lys Leu Asp Leu Thr Ala Arg Glu Leu                 250 255 260 ttt gcc cag cgc atg cgc act gca cgt ctg acg gca aag ttc atc ccc 931 Phe Ala Gln Arg Met Arg Thr Ala Arg Leu Thr Ala Lys Phe Ile Pro             265 270 275 atg gtt gag cag ctt ccg cag ctt gct ttg gtg gtc aac att gtt ggc 979 Met Val Glu Gln Leu Pro Gln Leu Ala Leu Val Val Asn Ile Val Gly         280 285 290 ggt ggc tat ttg gcc atg act ggt cac atc acg gtg ggc acg ttt gtg 1027 Gly Gly Tyr Leu Ala Met Thr Gly His Ile Thr Val Gly Thr Phe Val     295 300 305 gcg ttt tct tcc tat ctc act agc ttg tcg gcg gtg gct agg tcc ctg 1075 Ala Phe Ser Ser Tyr Leu Thr Ser Leu Ser Ala Val Ala Arg Ser Leu 310 315 320 325 tcg ggc atg ctc atg cgc gtg cag ttg gcg ctg tct tct gtg gag cgc 1123 Ser Gly Met Leu Met Arg Val Gln Leu Ala Leu Ser Ser Val Glu Arg                 330 335 340 atc ttt gaa gtc att gat ctt cag cct gaa cgc acc gat cct gca cac 1171 Ile Phe Glu Val Ile Asp Leu Gln Pro Glu Arg Thr Asp Pro Ala His             345 350 355 ccc ctg tca ctt ccc gac act ccc ctg ggt ctg tcg ttc aac aac gta 1219 Pro Leu Ser Leu Pro Asp Thr Pro Leu Gly Leu Ser Phe Asn Asn Val         360 365 370 gat ttc cgt ggg att ctc aac ggt ttt gag ctg ggt gtt cag gcc ggt 1267 Asp Phe Arg Gly Ile Leu Asn Gly Phe Glu Leu Gly Val Gln Ala Gly     375 380 385 gaa acc gtt gtg ttg gtg ggc cct cca ggt tca ggc aag acc atg gct 1315 Glu Thr Val Val Leu Val Gly Pro Pro Gly Ser Gly Lys Thr Met Ala 390 395 400 405 gtg cag ctt gct gga aac ttt tat caa cca gac agc ggc cac atc gcc 1363 Val Gln Leu Ala Gly Asn Phe Tyr Gln Pro Asp Ser Gly His Ile Ala                 410 415 420 ttt gat agc aac ggc cat cgc act cgc ttc gac gac ctc acc cac agc 1411 Phe Asp Ser Asn Gly His Arg Thr Arg Phe Asp Asp Leu Thr His Ser             425 430 435 gat atc cgc agg aat ctc atc gcg gtt ttt gat gag ccg ttc ttg tac 1459 Asp Ile Arg Arg Asn Leu Ile Ala Val Phe Asp Glu Pro Phe Leu Tyr         440 445 450 tcc tcc tcc ata ccg cga gaa cat ctc gat ggg ttt gga tgt cag 1504 Ser Ser Ser Ile Pro Arg Glu His Leu Asp Gly Phe Gly Cys Gln     455 460 465 tgatgagcag atcgaacacg cag 1527 <210> 324 <211> 468 <212> PRT <213> Corynebacterium glutamicum <400> 324 Met Lys Thr Glu Gln Ser Gln Lys Ala Gln Leu Ala Pro Lys Lys Ala   1 5 10 15 Pro Glu Lys Pro Gln Arg Ile Arg Gln Leu Ile Ser Val Ala Trp Gln              20 25 30 Arg Pro Trp Leu Thr Ser Phe Thr Val Ile Ser Ala Leu Ala Ala Thr          35 40 45 Leu Phe Glu Leu Thr Leu Pro Leu Leu Thr Gly Gly Ala Ile Asp Ile      50 55 60 Ala Leu Gly Asn Thr Gly Asp Thr Leu Thr Thr Asp Leu Leu Asp Arg  65 70 75 80 Phe Thr Pro Ser Gly Leu Ser Val Leu Thr Ser Val Ile Ala Leu Ile                  85 90 95 Val Leu Leu Ala Leu Leu Arg Tyr Ala Ser Gln Phe Gly Arg Arg Tyr             100 105 110 Thr Ala Gly Lys Leu Ser Met Gly Val Gln His Asp Val Arg Leu Lys         115 120 125 Thr Met Arg Ser Leu Gln Asn Leu Asp Gly Pro Gly Gln Asp Ser Ile     130 135 140 Arg Thr Gly Gln Val Val Ser Arg Ser Ile Ser Asp Ile Asn Met Val 145 150 155 160 Gln Ser Leu Val Ala Met Leu Pro Met Leu Ile Gly Asn Val Val Lys                 165 170 175 Leu Val Leu Thr Leu Val Ile Met Leu Ala Ile Ser Pro Pro Leu Thr             180 185 190 Ile Ile Ala Ala Val Leu Val Pro Leu Leu Leu Trp Ala Val Ala Tyr         195 200 205 Ser Arg Lys Ala Leu Phe Ala Ser Thr Trp Ser Ala Gln Gln Lys Ala     210 215 220 Ala Asp Leu Thr Thr His Val Glu Glu Thr Val Thr Gly Ile Arg Val 225 230 235 240 Val Lys Ala Phe Ala Gln Glu Asp Arg Glu Thr Asp Lys Leu Asp Leu                 245 250 255 Thr Ala Arg Glu Leu Phe Ala Gln Arg Met Arg Thr Ala Arg Leu Thr             260 265 270 Ala Lys Phe Ile Pro Met Val Glu Gln Leu Pro Gln Leu Ala Leu Val         275 280 285 Val Asn Ile Val Gly Gly Gly Tyr Leu Ala Met Thr Gly His Ile Thr     290 295 300 Val Gly Thr Phe Val Ala Phe Ser Ser Tyr Leu Thr Ser Leu Ser Ala 305 310 315 320 Val Ala Arg Ser Leu Ser Gly Met Leu Met Arg Val Gln Leu Ala Leu                 325 330 335 Ser Ser Val Glu Arg Ile Phe Glu Val Ile Asp Leu Gln Pro Glu Arg             340 345 350 Thr Asp Pro Ala His Pro Leu Ser Leu Pro Asp Thr Pro Leu Gly Leu         355 360 365 Ser Phe Asn Asn Val Asp Phe Arg Gly Ile Leu Asn Gly Phe Glu Leu     370 375 380 Gly Val Gln Ala Gly Glu Thr Val Val Leu Val Gly Pro Pro Gly Ser 385 390 395 400 Gly Lys Thr Met Ala Val Gln Leu Ala Gly Asn Phe Tyr Gln Pro Asp                 405 410 415 Ser Gly His Ile Ala Phe Asp Ser Asn Gly His Arg Thr Arg Phe Asp             420 425 430 Asp Leu Thr His Ser Asp Ile Arg Arg Asn Leu Ile Ala Val Phe Asp         435 440 445 Glu Pro Phe Leu Tyr Ser Ser Ser Ile Pro Arg Glu His Leu Asp Gly     450 455 460 Phe Gly Cys Gln 465 <210> 325 <211> 905 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (882) <223> RXA02225 <400> 325 caa act gag gag cgc ttt ggc gca gcg gct gat gaa gcc ttg gca atc 48 Gln Thr Glu Glu Arg Phe Gly Ala Ala Ala Asp Glu Ala Leu Ala Ile   1 5 10 15 atg ttg aag gaa gct cgt ctg cag tcg ttg ctg act ttt gtg cgc caa 96 Met Leu Lys Glu Ala Arg Leu Gln Ser Leu Leu Thr Phe Val Arg Gln              20 25 30 ctt gtc cca gcg gtg ttt tct gtg ggt ctt ttg gct tat gcg tca ctg 144 Leu Val Pro Ala Val Phe Ser Val Gly Leu Leu Ala Tyr Ala Ser Leu          35 40 45 ttg gct ttt gac ggt gac ata act ggt ggt gag atg atc tcg gtg acg 192 Leu Ala Phe Asp Gly Asp Ile Thr Gly Gly Glu Met Ile Ser Val Thr      50 55 60 ttg ctg gtg cca cct tcg ttg act gtg ttg ggt gtg tcg ctt ggc atg 240 Leu Leu Val Pro Pro Ser Leu Thr Val Leu Gly Val Ser Leu Gly Met  65 70 75 80 atg aca gag att tgg gct agg gga cag gct tcg aca aaa agg gtc caa 288 Met Thr Glu Ile Trp Ala Arg Gly Gln Ala Ser Thr Lys Arg Val Gln                  85 90 95 aac tta gtc act gaa ctg gat aag gcg gcc gct gag cca cga cct cag 336 Asn Leu Val Thr Glu Leu Asp Lys Ala Ala Ala Glu Pro Arg Pro Gln             100 105 110 cct gcc acc ttt gaa ttt gaa gag ggg atc acg gtg tgg gat cct tcg 384 Pro Ala Thr Phe Glu Phe Glu Glu Gly Ile Thr Val Trp Asp Pro Ser         115 120 125 aca cct gag gca cgc gat gtg att gat cgg gag ttg gag gcg ctt cag 432 Thr Pro Glu Ala Arg Asp Val Ile Asp Arg Glu Leu Glu Ala Leu Gln     130 135 140 gtt cgc gaa gat gtc att gtg gct cct cac cgc gtc agc gtg ttt gaa 480 Val Arg Glu Asp Val Ile Val Ala Pro His Arg Val Ser Val Phe Glu 145 150 155 160 ggt gtg ctg aag gat aat ttg aat ccg atg ggc act atc gca ccg gag 528 Gly Val Leu Lys Asp Asn Leu Asn Pro Met Gly Thr Ile Ala Pro Glu                 165 170 175 atg ctg cgc gct gct ctt cat gct gca agt tgt gag gac atc ttg agc 576 Met Leu Arg Ala Ala Leu His Ala Ala Ser Cys Glu Asp Ile Leu Ser             180 185 190 cga ttg ggt gct gat ctg aac atg ccg ggg gag ttt gag ctt cca gat 624 Arg Leu Gly Ala Asp Leu Asn Met Pro Gly Glu Phe Glu Leu Pro Asp         195 200 205 acc ttg atc ggc gag gcc gga ttg aat ctc tcc ggt ggc caa cgc cag 672 Thr Leu Ile Gly Glu Ala Gly Leu Asn Leu Ser Gly Gly Gln Arg Gln     210 215 220 agg att gct ttg gca cga ttc ttg gct gtt gat cct gag gtg ctc att 720 Arg Ile Ala Leu Ala Arg Phe Leu Ala Val Asp Pro Glu Val Leu Ile 225 230 235 240 ttg gat gaa ccg acc acg ggg ttg gat gcg gtg acc ctg gat gaa gtg 768 Leu Asp Glu Pro Thr Thr Gly Leu Asp Ala Val Thr Leu Asp Glu Val                 245 250 255 gca cat cgc gtc gaa aag ctt cgt cga ggc cgg aaa acc gtc gtc att 816 Ala His Arg Val Glu Lys Leu Arg Arg Gly Arg Lys Thr Val Val Ile             260 265 270 acg tcg aac ccg acg tgg cac ggc gtc gca aag cag atg caa tct gat 864 Thr Ser Asn Pro Thr Trp His Gly Val Ala Lys Gln Met Gln Ser Asp         275 280 285 ttt tcg gaa ggg gtg aag tagatggcgc agcatgagcg cgt 905 Phe Ser Glu Gly Val Lys     290 <210> 326 <211> 294 <212> PRT <213> Corynebacterium glutamicum <400> 326 Gln Thr Glu Glu Arg Phe Gly Ala Ala Ala Asp Glu Ala Leu Ala Ile   1 5 10 15 Met Leu Lys Glu Ala Arg Leu Gln Ser Leu Leu Thr Phe Val Arg Gln              20 25 30 Leu Val Pro Ala Val Phe Ser Val Gly Leu Leu Ala Tyr Ala Ser Leu          35 40 45 Leu Ala Phe Asp Gly Asp Ile Thr Gly Gly Glu Met Ile Ser Val Thr      50 55 60 Leu Leu Val Pro Pro Ser Leu Thr Val Leu Gly Val Ser Leu Gly Met  65 70 75 80 Met Thr Glu Ile Trp Ala Arg Gly Gln Ala Ser Thr Lys Arg Val Gln                  85 90 95 Asn Leu Val Thr Glu Leu Asp Lys Ala Ala Ala Glu Pro Arg Pro Gln             100 105 110 Pro Ala Thr Phe Glu Phe Glu Glu Gly Ile Thr Val Trp Asp Pro Ser         115 120 125 Thr Pro Glu Ala Arg Asp Val Ile Asp Arg Glu Leu Glu Ala Leu Gln     130 135 140 Val Arg Glu Asp Val Ile Val Ala Pro His Arg Val Ser Val Phe Glu 145 150 155 160 Gly Val Leu Lys Asp Asn Leu Asn Pro Met Gly Thr Ile Ala Pro Glu                 165 170 175 Met Leu Arg Ala Ala Leu His Ala Ala Ser Cys Glu Asp Ile Leu Ser             180 185 190 Arg Leu Gly Ala Asp Leu Asn Met Pro Gly Glu Phe Glu Leu Pro Asp         195 200 205 Thr Leu Ile Gly Glu Ala Gly Leu Asn Leu Ser Gly Gly Gln Arg Gln     210 215 220 Arg Ile Ala Leu Ala Arg Phe Leu Ala Val Asp Pro Glu Val Leu Ile 225 230 235 240 Leu Asp Glu Pro Thr Thr Gly Leu Asp Ala Val Thr Leu Asp Glu Val                 245 250 255 Ala His Arg Val Glu Lys Leu Arg Arg Gly Arg Lys Thr Val Val Ile             260 265 270 Thr Ser Asn Pro Thr Trp His Gly Val Ala Lys Gln Met Gln Ser Asp         275 280 285 Phe Ser Glu Gly Val Lys     290 <210> 327 <211> 1050 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (1027) <223> RXA02253 <400> 327 tgaggacatt tcccaagtga aaggcttcgg cccgaaactt gcggaggctg tctatgaagg 60 tcttcacgcg tcaaaataag tagatcgcta ggatgtaacc atg att caa tcc act 115                                             Met Ile Gln Ser Thr                                               1 5 ggg gtc acg cac act gat aag tct gca caa gaa aat cct gtg aag tac 163 Gly Val Thr His Thr Asp Lys Ser Ala Gln Glu Asn Pro Val Lys Tyr                  10 15 20 agg gac aat ttc aca cct gtc atc atc acc ggt atg tca ggc gca ggt 211 Arg Asp Asn Phe Thr Pro Val Ile Ile Thr Gly Met Ser Gly Ala Gly              25 30 35 ctg agc aca gca gcc cga gtc ctc gaa gac ttg ggt tgg tat gtg gcg 259 Leu Ser Thr Ala Ala Arg Val Leu Glu Asp Leu Gly Trp Tyr Val Ala          40 45 50 cac aat att cca cca cag atc atc ctg gaa tta att gat atg tgc gct 307 His Asn Ile Pro Pro Gln Ile Ile Leu Glu Leu Ile Asp Met Cys Ala      55 60 65 cgg gaa gat tct ccc gtc gac aaa gtt gca gtc gtg tgc gat gtg cgc 355 Arg Glu Asp Ser Pro Val Asp Lys Val Ala Val Val Cys Asp Val Arg  70 75 80 85 tcc cgt gaa ttc cgc gga agc ctc acc cag gtt gtt tca gag ctg cgt 403 Ser Arg Glu Phe Arg Gly Ser Leu Thr Gln Val Val Ser Glu Leu Arg                  90 95 100 gat aag cag ctc gat ccc acg gtg tta ttt ctg gaa gca cgc gat gag 451 Asp Lys Gln Leu Asp Pro Thr Val Leu Phe Leu Glu Ala Arg Asp Glu             105 110 115 gtg ctg atc aag cga ttc gat aat gtg cgc cgc acc cat cct ttg cag 499 Val Leu Ile Lys Arg Phe Asp Asn Val Arg Arg Thr His Pro Leu Gln         120 125 130 ggc agc caa acc ctt cag gtg ggt att gaa cgt gaa cga acc gtg ctg 547 Gly Ser Gln Thr Leu Gln Val Gly Ile Glu Arg Glu Arg Thr Val Leu     135 140 145 tct cct gtg aag gaa gac gct tca gtg gtc atc gat acc tcg gat ctg 595 Ser Pro Val Lys Glu Asp Ala Ser Val Val Ile Asp Thr Ser Asp Leu 150 155 160 165 tcc gtg cat gat ttg cgc cgc gcc atc gaa tcc tcg ttt agg aca atc 643 Ser Val His Asp Leu Arg Arg Ala Ile Glu Ser Ser Phe Arg Thr Ile                 170 175 180 gcc acg cgc acc cag cac gtc acc att gaa tca ttc ggt ttc aaa cac 691 Ala Thr Arg Thr Gln His Val Thr Ile Glu Ser Phe Gly Phe Lys His             185 190 195 ggc tca cca cgc gac gcc gac ttt gtt gtg gac gtg cgt ttc ttg ccg 739 Gly Ser Pro Arg Asp Ala Asp Phe Val Val Asp Val Arg Phe Leu Pro         200 205 210 aac cca ttc tgg gtt cca gag ctg cgc cca ttt agg gga gtg gac aag 787 Asn Pro Phe Trp Val Pro Glu Leu Arg Pro Phe Arg Gly Val Asp Lys     215 220 225 cca gta tct gac tat gtg ctc tcc caa aaa ggc gca gaa gaa ttt ttg 835 Pro Val Ser Asp Tyr Val Leu Ser Gln Lys Gly Ala Glu Glu Phe Leu 230 235 240 245 aac aac ttt gtg gac atg ctc aaa gac atg ctt ccg gga tac cgc cac 883 Asn Asn Phe Val Asp Met Leu Lys Asp Met Leu Pro Gly Tyr Arg His                 250 255 260 gaa gga aaa aac ttc atc aca atc ggt gtc ggc tgc acc ggt gga cac 931 Glu Gly Lys Asn Phe Ile Thr Ile Gly Val Gly Cys Thr Gly Gly His             265 270 275 cac aga tca gtt gcg gtg tct gaa gaa cta gcc aaa aga atc gca gat 979 His Arg Ser Val Ala Val Ser Glu Glu Leu Ala Lys Arg Ile Ala Asp         280 285 290 cag acc acg ctc gac gtg tct gta gta cac cgc gat att aac cgc cac 1027 Gln Thr Thr Leu Asp Val Ser Val Val His Arg Asp Ile Asn Arg His     295 300 305 taggaaaggg gccaactaat tga 1050 <210> 328 <211> 309 <212> PRT <213> Corynebacterium glutamicum <400> 328 Met Ile Gln Ser Thr Gly Val Thr His Thr Asp Lys Ser Ala Gln Glu   1 5 10 15 Asn Pro Val Lys Tyr Arg Asp Asn Phe Thr Pro Val Ile Ile Thr Gly              20 25 30 Met Ser Gly Ala Gly Leu Ser Thr Ala Ala Arg Val Leu Glu Asp Leu          35 40 45 Gly Trp Tyr Val Ala His Asn Ile Pro Pro Gln Ile Ile Leu Glu Leu      50 55 60 Ile Asp Met Cys Ala Arg Glu Asp Ser Pro Val Asp Lys Val Ala Val  65 70 75 80 Val Cys Asp Val Arg Ser Arg Glu Phe Arg Gly Ser Leu Thr Gln Val                  85 90 95 Val Ser Glu Leu Arg Asp Lys Gln Leu Asp Pro Thr Val Leu Phe Leu             100 105 110 Glu Ala Arg Asp Glu Val Leu Ile Lys Arg Phe Asp Asn Val Arg Arg         115 120 125 Thr His Pro Leu Gln Gly Ser Gln Thr Leu Gln Val Gly Ile Glu Arg     130 135 140 Glu Arg Thr Val Leu Ser Pro Val Lys Glu Asp Ala Ser Val Val Ile 145 150 155 160 Asp Thr Ser Asp Leu Ser Val His Asp Leu Arg Arg Ala Ile Glu Ser                 165 170 175 Ser Phe Arg Thr Ile Ala Thr Arg Thr Gln His Val Thr Ile Glu Ser             180 185 190 Phe Gly Phe Lys His Gly Ser Pro Arg Asp Ala Asp Phe Val Val Asp         195 200 205 Val Arg Phe Leu Pro Asn Pro Phe Trp Val Pro Glu Leu Arg Pro Phe     210 215 220 Arg Gly Val Asp Lys Pro Val Ser Asp Tyr Val Leu Ser Gln Lys Gly 225 230 235 240 Ala Glu Glu Phe Leu Asn Asn Phe Val Asp Met Leu Lys Asp Met Leu                 245 250 255 Pro Gly Tyr Arg His Glu Gly Lys Asn Phe Ile Thr Ile Gly Val Gly             260 265 270 Cys Thr Gly Gly His His Arg Ser Val Ala Val Ser Glu Glu Leu Ala         275 280 285 Lys Arg Ile Ala Asp Gln Thr Thr Leu Asp Val Ser Val Val His Arg     290 295 300 Asp Ile Asn Arg His 305 <210> 329 <211> 558 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (535) <223> RXN01881 <400> 329 accggccctg cggcctcaac cgccgaccag cgcggcgcac acattttgac tgtttcataa 60 taaagacaaa cttaagtatc ggagtcgaag aaaaaccaca atg gcc aat ctg att 115                                             Met Ala Asn Leu Ile                                               1 5 aat ctc gag aac gtc tcc aaa acc tgg gga tta aaa acg ctt ctc gac 163 Asn Leu Glu Asn Val Ser Lys Thr Trp Gly Leu Lys Thr Leu Leu Asp                  10 15 20 ggt gtc tcc tta ggt gtt caa acc ggc gac cgc att ggc gtc gtc ggc 211 Gly Val Ser Leu Gly Val Gln Thr Gly Asp Arg Ile Gly Val Val Gly              25 30 35 ctc aat ggt ggc gga aaa acc acc ctg ctg gaa gta ctt act ggc atc 259 Leu Asn Gly Gly Gly Lys Thr Thr Leu Leu Glu Val Leu Thr Gly Ile          40 45 50 gaa aag ccg gat cag ggc cgt gtg tct cac aac tct gac ctg cgc atg 307 Glu Lys Pro Asp Gln Gly Arg Val Ser His Asn Ser Asp Leu Arg Met      55 60 65 gct gtg gtg acg cag cgt gct gaa ctc aat gat gac gac acc gtc gct 355 Ala Val Val Thr Gln Arg Ala Glu Leu Asn Asp Asp Asp Thr Val Ala  70 75 80 85 gac gtg gtg ctt gga cct ttg ggt ttg gaa gtt ttc gaa tgg gca tca 403 Asp Val Val Leu Gly Pro Leu Gly Leu Glu Val Phe Glu Trp Ala Ser                  90 95 100 aac gcc acg gtg cgc gac gtc ctc ggt ggc ttg ggc att gtc gat ctt 451 Asn Ala Thr Val Arg Asp Val Leu Gly Gly Leu Gly Ile Val Asp Leu             105 110 115 ggc ctt gac acc aag gtg ggc aaa cct ttt ccg gtg ggc gaa gcg ccg 499 Gly Leu Asp Thr Lys Val Gly Lys Pro Phe Pro Val Gly Glu Ala Pro         120 125 130 acg cac caa cct ggc cgc cgc gct ggt tcg cga cct tgacctgatc 545 Thr His Gln Pro Gly Arg Arg Ala Gly Ser Arg Pro     135 140 145 gtgctcgacg agc 558 <210> 330 <211> 145 <212> PRT <213> Corynebacterium glutamicum <400> 330 Met Ala Asn Leu Ile Asn Leu Glu Asn Val Ser Lys Thr Trp Gly Leu   1 5 10 15 Lys Thr Leu Leu Asp Gly Val Ser Leu Gly Val Gln Thr Gly Asp Arg              20 25 30 Ile Gly Val Val Gly Leu Asn Gly Gly Gly Lys Thr Thr Leu Leu Glu          35 40 45 Val Leu Thr Gly Ile Glu Lys Pro Asp Gln Gly Arg Val Ser His Asn      50 55 60 Ser Asp Leu Arg Met Ala Val Val Thr Gln Arg Ala Glu Leu Asn Asp  65 70 75 80 Asp Asp Thr Val Ala Asp Val Val Leu Gly Pro Leu Gly Leu Glu Val                  85 90 95 Phe Glu Trp Ala Ser Asn Ala Thr Val Arg Asp Val Leu Gly Gly Leu             100 105 110 Gly Ile Val Asp Leu Gly Leu Asp Thr Lys Val Gly Lys Pro Phe Pro         115 120 125 Val Gly Glu Ala Pro Thr His Gln Pro Gly Arg Arg Ala Gly Ser Arg     130 135 140 Pro 145 <210> 331 <211> 564 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (541) <223> FRXA01881 <400> 331 accggccctg cggcctcaac cgccgaccag cgcggcgcac acattttgac tgtttcataa 60 taaagacaaa cttaagtatc ggagtcgaag aaaaaccaca atg gcc aat ctg att 115                                             Met Ala Asn Leu Ile                                               1 5 aat ctc gag aac gtc tcc aaa acc tgg gga tta aaa acg ctt ctc gac 163 Asn Leu Glu Asn Val Ser Lys Thr Trp Gly Leu Lys Thr Leu Leu Asp                  10 15 20 ggt gtc tcc tta ggt gtt caa acc ggc gac cgc att ggc gtc gtc ggc 211 Gly Val Ser Leu Gly Val Gln Thr Gly Asp Arg Ile Gly Val Val Gly              25 30 35 ctc aat ggt ggc gga aaa acc acc ctg ctg gaa gta ctt act ggc atc 259 Leu Asn Gly Gly Gly Lys Thr Thr Leu Leu Glu Val Leu Thr Gly Ile          40 45 50 gaa aag ccg gat cag ggc cgt gtg tct cac aac tct gac ctg cgc atg 307 Glu Lys Pro Asp Gln Gly Arg Val Ser His Asn Ser Asp Leu Arg Met      55 60 65 gct gtg gtg acg cag cgt gct gaa ctc aat gat gac gac acc gtc gct 355 Ala Val Val Thr Gln Arg Ala Glu Leu Asn Asp Asp Asp Thr Val Ala  70 75 80 85 gac gtg gtg ctt gga cct ttg ggt ttg gaa gtt ttc gaa tgg gca tca 403 Asp Val Val Leu Gly Pro Leu Gly Leu Glu Val Phe Glu Trp Ala Ser                  90 95 100 aac gcc acg gtg cgc gac gtc ctc ggt ggc ttg ggc att gtc gat ctt 451 Asn Ala Thr Val Arg Asp Val Leu Gly Gly Leu Gly Ile Val Asp Leu             105 110 115 ggc ctt gac acc aag gtg ggg caa acc ttt tcc ggt ggg cga agc gcc 499 Gly Leu Asp Thr Lys Val Gly Gln Thr Phe Ser Gly Gly Arg Ser Ala         120 125 130 gac gca cca acc tgg ccg ccg cgc tgg ttc gcg acc ttg acc 541 Asp Ala Pro Thr Trp Pro Pro Arg Trp Phe Ala Thr Leu Thr     135 140 145 tgatcgtgct cgacgagccc acc 564 <210> 332 <211> 147 <212> PRT <213> Corynebacterium glutamicum <400> 332 Met Ala Asn Leu Ile Asn Leu Glu Asn Val Ser Lys Thr Trp Gly Leu   1 5 10 15 Lys Thr Leu Leu Asp Gly Val Ser Leu Gly Val Gln Thr Gly Asp Arg              20 25 30 Ile Gly Val Val Gly Leu Asn Gly Gly Gly Lys Thr Thr Leu Leu Glu          35 40 45 Val Leu Thr Gly Ile Glu Lys Pro Asp Gln Gly Arg Val Ser His Asn      50 55 60 Ser Asp Leu Arg Met Ala Val Val Thr Gln Arg Ala Glu Leu Asn Asp  65 70 75 80 Asp Asp Thr Val Ala Asp Val Val Leu Gly Pro Leu Gly Leu Glu Val                  85 90 95 Phe Glu Trp Ala Ser Asn Ala Thr Val Arg Asp Val Leu Gly Gly Leu             100 105 110 Gly Ile Val Asp Leu Gly Leu Asp Thr Lys Val Gly Gln Thr Phe Ser         115 120 125 Gly Gly Arg Ser Ala Asp Ala Pro Thr Trp Pro Pro Arg Trp Phe Ala     130 135 140 Thr Leu Thr 145 <210> 333 <211> 813 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (790) <223> RXA00526 <400> 333 ggtggagcag gcggcggctc cttttagtcc tgcggcccct tttgaccctg cagcccctgc 60 cgtttctgcc aagcaaaccg tgggccaggt gatttagcct atg agc ctc atc gaa 115                                             Met Ser Leu Ile Glu                                               1 5 atg cga aat att gtc aag acc tac aac att gga tct gaa ggt gaa ctc 163 Met Arg Asn Ile Val Lys Thr Tyr Asn Ile Gly Ser Glu Gly Glu Leu                  10 15 20 acc gtg ttg cac ggt gtg gat ttc cat gtg gac cgt ggc gaa ttc gtg 211 Thr Val Leu His Gly Val Asp Phe His Val Asp Arg Gly Glu Phe Val              25 30 35 tcg gtt gtg ggt acg tcc ggc tca ggt aaa tca acg atg atg aac atc 259 Ser Val Val Gly Thr Ser Gly Ser Gly Lys Ser Thr Met Met Asn Ile          40 45 50 att ggg ttg ttg gat aag cca act gat ggc acg tac acc ttg gat ggc 307 Ile Gly Leu Leu Asp Lys Pro Thr Asp Gly Thr Tyr Thr Leu Asp Gly      55 60 65 gtg gat gtg ttg gat atc agc gat gat gct ttg gcg agc cac cgc gct 355 Val Asp Val Leu Asp Ile Ser Asp Asp Ala Leu Ala Ser His Arg Ala  70 75 80 85 aaa tcg att ggt ttt gtg ttt cag aac ttc aat ctg att ggc cgg atc 403 Lys Ser Ile Gly Phe Val Phe Gln Asn Phe Asn Leu Ile Gly Arg Ile                  90 95 100 gat gcg ttg aag aat gtg gaa atg ccc atg atg tat gcg ggc att ccg 451 Asp Ala Leu Lys Asn Val Glu Met Pro Met Met Tyr Ala Gly Ile Pro             105 110 115 gct aag cag cgg aga agt cgt gcg gtt gaa tta ttg gaa atg gtc ggg 499 Ala Lys Gln Arg Arg Ser Arg Ala Val Glu Leu Leu Glu Met Val Gly         120 125 130 atg ggt gag cgt ctc aac cat gag ccc aat gag ctt tcg ggt ggt cag 547 Met Gly Glu Arg Leu Asn His Glu Pro Asn Glu Leu Ser Gly Gly Gln     135 140 145 aag cag cgc gtg gcc att gct cgc gcg ttg gcg aac gat cct gag atc 595 Lys Gln Arg Val Ala Ile Ala Arg Ala Leu Ala Asn Asp Pro Glu Ile 150 155 160 165 att ctt gct gat gaa cca act ggt gcg ttg gat tct gca acg ggc cgg 643 Ile Leu Ala Asp Glu Pro Thr Gly Ala Leu Asp Ser Ala Thr Gly Arg                 170 175 180 atg gtg atg gat att ttc cac cag ctc aac aag gag cag ggc aaa acc 691 Met Val Met Asp Ile Phe His Gln Leu Asn Lys Glu Gln Gly Lys Thr             185 190 195 atc gtg ttt att act cac aac cct gag ctt gct gat gaa tct gat cgg 739 Ile Val Phe Ile Thr His Asn Pro Glu Leu Ala Asp Glu Ser Asp Arg         200 205 210 gtg gtc acc atg gtt gac ggg cgc atc att ggg tct gag gtg aaa cac 787 Val Val Thr Met Val Asp Gly Arg Ile Ile Gly Ser Glu Val Lys His     215 220 225 tca tgagccttgc agaatcaatt ctt 813 Ser 230 <210> 334 <211> 230 <212> PRT <213> Corynebacterium glutamicum <400> 334 Met Ser Leu Ile Glu Met Arg Asn Ile Val Lys Thr Tyr Asn Ile Gly   1 5 10 15 Ser Glu Gly Glu Leu Thr Val Leu His Gly Val Asp Phe His Val Asp              20 25 30 Arg Gly Glu Phe Val Ser Val Val Gly Thr Ser Gly Ser Gly Lys Ser          35 40 45 Thr Met Met Asn Ile Ile Gly Leu Leu Asp Lys Pro Thr Asp Gly Thr      50 55 60 Tyr Thr Leu Asp Gly Val Asp Val Leu Asp Ile Ser Asp Asp Ala Leu  65 70 75 80 Ala Ser His Arg Ala Lys Ser Ile Gly Phe Val Phe Gln Asn Phe Asn                  85 90 95 Leu Ile Gly Arg Ile Asp Ala Leu Lys Asn Val Glu Met Pro Met Met             100 105 110 Tyr Ala Gly Ile Pro Ala Lys Gln Arg Arg Ser Arg Ala Val Glu Leu         115 120 125 Leu Glu Met Val Gly Met Gly Glu Arg Leu Asn His Glu Pro Asn Glu     130 135 140 Leu Ser Gly Gly Gln Lys Gln Arg Val Ala Ile Ala Arg Ala Leu Ala 145 150 155 160 Asn Asp Pro Glu Ile Ile Leu Ala Asp Glu Pro Thr Gly Ala Leu Asp                 165 170 175 Ser Ala Thr Gly Arg Met Val Met Asp Ile Phe His Gln Leu Asn Lys             180 185 190 Glu Gln Gly Lys Thr Ile Val Phe Ile Thr His Asn Pro Glu Leu Ala         195 200 205 Asp Glu Ser Asp Arg Val Val Thr Met Val Asp Gly Arg Ile Ily Gly     210 215 220 Ser Glu Val Lys His Ser 225 230 <210> 335 <211> 1008 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (985) <223> RXN00733 <400> 335 acggcgaggt tgtcggtatt ggaacgcaca cgaatttgct gaacacgtgc ggtacctacc 60 gtgaaattgt tgaatcccaa gagactgcgc aggcgcaatc atg agt aat act gca 115                                             Met ser asn thr ala                                               1 5 ggc ccc cgc ggg cgt tcc cat cag gca gac gcc gcg ccg aat caa aag 163 Gly Pro Arg Gly Arg Ser His Gln Ala Asp Ala Ala Pro Asn Gln Lys                  10 15 20 gca cag aat ttc gga cca tct gcc aaa agg ctt ttc gga att cta ggc 211 Ala Gln Asn Phe Gly Pro Ser Ala Lys Arg Leu Phe Gly Ile Leu Gly              25 30 35 cat gac cgt aac acc tta att ttt gtt atc ttc cta gcc gtc ctg agc 259 His Asp Arg Asn Thr Leu Ile Phe Val Ile Phe Leu Ala Val Leu Ser          40 45 50 gtt gga ctt acc gtc ttg ggc cca tgg ttg ctg ggt aaa gcc acc aac 307 Val Gly Leu Thr Val Leu Gly Pro Trp Leu Leu Gly Lys Ala Thr Asn      55 60 65 gtg gtg ttt gaa gga ttc cta tct aag cgc atg ccg gct ggt gcg tca 355 Val Val Phe Glu Gly Phe Leu Ser Lys Arg Met Pro Ala Gly Ala Ser  70 75 80 85 aag gaa gat atc atc gcg cag ttg cag gct gca ggt aaa cat aat cag 403 Lys Glu Asp Ile Ile Ala Gln Leu Gln Ala Ala Gly Lys His Asn Gln                  90 95 100 gct tcc atg atg gaa gac atg aac ctt gtt cca ggc tca ggc att gat 451 Ala Ser Met Met Glu Asp Met Asn Leu Val Pro Gly Ser Gly Ile Asp             105 110 115 ttt gaa aaa tta gcc atg atc ctc gga ctg gtg atc ggt gct tat ctc 499 Phe Glu Lys Leu Ala Met Ile Leu Gly Leu Val Ile Gly Ala Tyr Leu         120 125 130 atc ggt agc ctg ttg tcg ttg ttc cag gcg cgg atg ctc aac cgc atc 547 Ile Gly Ser Leu Leu Ser Leu Phe Gln Ala Arg Met Leu Asn Arg Ile     135 140 145 gtg caa agt gcc atg cac cgg ctg cgc atg gag gtg gag gaa aaa atc 595 Val Gln Ser Ala Met His Arg Leu Arg Met Glu Val Glu Glu Lys Ile 150 155 160 165 cac cgc cta ccg ctg agc tat ttc gat tcc atc aaa cgt ggt gat ctg 643 His Arg Leu Pro Leu Ser Tyr Phe Asp Ser Ile Lys Arg Gly Asp Leu                 170 175 180 ctt agc cgt gtg acc aac gat gtg gat aat atc ggt caa tcc ctg caa 691 Leu Ser Arg Val Thr Asn Asp Val Asp Asn Ile Gly Gln Ser Leu Gln             185 190 195 caa acc ttg tca cag gcg atc act tcc cta ctg acc gtc atc ggt gtg 739 Gln Thr Leu Ser Gln Ala Ile Thr Ser Leu Leu Thr Val Ile Gly Val         200 205 210 ttg gtg atg atg ttt atc atc tcc cca ctg ctc gca ctc gtg gcg ctg 787 Leu Val Met Met Phe Ile Ile Ser Pro Leu Leu Ala Leu Val Ala Leu     215 220 225 gta tcc att ccg gtc acc atc gtg gtc act gtg gtg gtt gcg agc cgt 835 Val Ser Ile Pro Val Thr Ile Val Val Thr Val Val Val Ala Ser Arg 230 235 240 245 tcc cag aaa ctc ttt gcg gaa cag tgg aag cag acc ggt att ttg aat 883 Ser Gln Lys Leu Phe Ala Glu Gln Trp Lys Gln Thr Gly Ile Leu Asn                 250 255 260 gcg cgc ctg gag gaa acc tac tct ggc cac gcc gtg gtt aag gtt ttc 931 Ala Arg Leu Glu Glu Thr Tyr Ser Gly His Ala Val Val Lys Val Phe             265 270 275 gga cac caa aag gat gtt caa gaa gca ttc gag gaa gaa aat caa gct 979 Gly His Gln Lys Asp Val Gln Glu Ala Phe Glu Glu Glu Asn Gln Ala         280 285 290 tgt gta taaggccagc tttggtgccc agt 1008 Cys val     295 <210> 336 <211> 295 <212> PRT <213> Corynebacterium glutamicum <400> 336 Met Ser Asn Thr Ala Gly Pro Arg Gly Arg Ser His Gln Ala Asp Ala   1 5 10 15 Ala Pro Asn Gln Lys Ala Gln Asn Phe Gly Pro Ser Ala Lys Arg Leu              20 25 30 Phe Gly Ile Leu Gly His Asp Arg Asn Thr Leu Ile Phe Val Ile Phe          35 40 45 Leu Ala Val Leu Ser Val Gly Leu Thr Val Leu Gly Pro Trp Leu Leu      50 55 60 Gly Lys Ala Thr Asn Val Val Phe Glu Gly Phe Leu Ser Lys Arg Met  65 70 75 80 Pro Ala Gly Ala Ser Lys Glu Asp Ile Ile Ala Gln Leu Gln Ala Ala                  85 90 95 Gly Lys His Asn Gln Ala Ser Met Met Glu Asp Met Asn Leu Val Pro             100 105 110 Gly Ser Gly Ile Asp Phe Glu Lys Leu Ala Met Ile Leu Gly Leu Val         115 120 125 Ile Gly Ala Tyr Leu Ile Gly Ser Leu Leu Ser Leu Phe Gln Ala Arg     130 135 140 Met Leu Asn Arg Ile Val Gln Ser Ala Met His Arg Leu Arg Met Glu 145 150 155 160 Val Glu Glu Lys Ile His Arg Leu Pro Leu Ser Tyr Phe Asp Ser Ile                 165 170 175 Lys Arg Gly Asp Leu Leu Ser Arg Val Thr Asn Asp Val Asp Asn Ile             180 185 190 Gly Gln Ser Leu Gln Gln Thr Leu Ser Gln Ala Ile Thr Ser Leu Leu         195 200 205 Thr Val Ile Gly Val Leu Val Met Met Phe Ile Ile Ser Pro Leu Leu     210 215 220 Ala Leu Val Ala Leu Val Ser Ile Pro Val Thr Ile Val Val Thr Val 225 230 235 240 Val Val Ala Ser Arg Ser Gln Lys Leu Phe Ala Glu Gln Trp Lys Gln                 245 250 255 Thr Gly Ile Leu Asn Ala Arg Leu Glu Glu Thr Tyr Ser Gly His Ala             260 265 270 Val Val Lys Val Phe Gly His Gln Lys Asp Val Gln Glu Ala Phe Glu         275 280 285 Glu Glu Asn Gln Ala Cys Val     290 295 <210> 337 <211> 508 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (508) <223> FRXA00733 <400> 337 acggcgaggt tgtcggtatt ggaacgcaca cgaatttgct gaacacgtgc ggtacctacc 60 gtgaaattgt tgaatcccaa gagactgcgc aggcgcaatc atg agt aat act gca 115                                             Met ser asn thr ala                                               1 5 ggc ccc cgc ggg cgt tcc cat cag gca gac gcc gcg ccg aat caa aag 163 Gly Pro Arg Gly Arg Ser His Gln Ala Asp Ala Ala Pro Asn Gln Lys                  10 15 20 gca cag aat ttc gga cca tct gcc aaa agg ctt ttc gga att cta ggc 211 Ala Gln Asn Phe Gly Pro Ser Ala Lys Arg Leu Phe Gly Ile Leu Gly              25 30 35 cat gac cgt aac acc tta att ttt gtt atc ttc cta gcc gtc ctg agc 259 His Asp Arg Asn Thr Leu Ile Phe Val Ile Phe Leu Ala Val Leu Ser          40 45 50 gtt gga ctt acc gtc ttg ggc cca tgg ttg ctg ggt aaa gcc acc aac 307 Val Gly Leu Thr Val Leu Gly Pro Trp Leu Leu Gly Lys Ala Thr Asn      55 60 65 gtg gtg ttt gaa gga ttc cta tct aag cgc atg ccg gct ggt gcg tca 355 Val Val Phe Glu Gly Phe Leu Ser Lys Arg Met Pro Ala Gly Ala Ser  70 75 80 85 aag gaa gat atc atc gcg cag ttg cag gct gca ggt aaa cat aat cag 403 Lys Glu Asp Ile Ile Ala Gln Leu Gln Ala Ala Gly Lys His Asn Gln                  90 95 100 gct tcc atg atg gaa gac atg aac ctt gtt cca ggc tca ggc att gat 451 Ala Ser Met Met Glu Asp Met Asn Leu Val Pro Gly Ser Gly Ile Asp             105 110 115 ttt gaa aaa tta gcc atg atc ctc gga ctg gtg atc ggt gct tat ctc 499 Phe Glu Lys Leu Ala Met Ile Leu Gly Leu Val Ile Gly Ala Tyr Leu         120 125 130 att cgt agc 508 Ile Arg Ser     135 <210> 338 <211> 136 <212> PRT <213> Corynebacterium glutamicum <400> 338 Met Ser Asn Thr Ala Gly Pro Arg Gly Arg Ser His Gln Ala Asp Ala   1 5 10 15 Ala Pro Asn Gln Lys Ala Gln Asn Phe Gly Pro Ser Ala Lys Arg Leu              20 25 30 Phe Gly Ile Leu Gly His Asp Arg Asn Thr Leu Ile Phe Val Ile Phe          35 40 45 Leu Ala Val Leu Ser Val Gly Leu Thr Val Leu Gly Pro Trp Leu Leu      50 55 60 Gly Lys Ala Thr Asn Val Val Phe Glu Gly Phe Leu Ser Lys Arg Met  65 70 75 80 Pro Ala Gly Ala Ser Lys Glu Asp Ile Ile Ala Gln Leu Gln Ala Ala                  85 90 95 Gly Lys His Asn Gln Ala Ser Met Met Glu Asp Met Asn Leu Val Pro             100 105 110 Gly Ser Gly Ile Asp Phe Glu Lys Leu Ala Met Ile Leu Gly Leu Val         115 120 125 Ile Gly Ala Tyr Leu Ile Arg Ser     130 135 <210> 339 <211> 692 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (669) <223> RXA00735 <400> 339 ggt ccc acc ggt gcg ggc aag acc aca ttg gtg aat ctg atc atg cgt 48 Gly Pro Thr Gly Ala Gly Lys Thr Thr Leu Val Asn Leu Ile Met Arg   1 5 10 15 ttc tac gac atc aac agc ggt tcc atc act ctt ggt gaa aca gca caa 96 Phe Tyr Asp Ile Asn Ser Gly Ser Ile Thr Leu Gly Glu Thr Ala Gln              20 25 30 gac gcc gtg gat atc cgc acc atg gct aga gaa gat ctg cga tca cga 144 Asp Ala Val Asp Ile Arg Thr Met Ala Arg Glu Asp Leu Arg Ser Arg          35 40 45 acc ggc atg gtg ttg cag gat acg tgg ctg ttt gcc gga acc atc agg 192 Thr Gly Met Val Leu Gln Asp Thr Trp Leu Phe Ala Gly Thr Ile Arg      50 55 60 gat aac att ctt tac ggt aga cct gaa gca act gag gaa gaa atg ctt 240 Asp Asn Ile Leu Tyr Gly Arg Pro Glu Ala Thr Glu Glu Glu Met Leu  65 70 75 80 gct gcg tcc aag gcc gcc tac gtg gat cgt ttt gtc cgt tcc ctg cca 288 Ala Ala Ser Lys Ala Ala Tyr Val Asp Arg Phe Val Arg Ser Leu Pro                  85 90 95 gaa ggc tac gac acc gta ctt gat gat gaa gcc atg aac cta tcg gtg 336 Glu Gly Tyr Asp Thr Val Leu Asp Asp Glu Ala Met Asn Leu Ser Val             100 105 110 ggt gaa cgc cag ctg atc acc atc gcg cgt gca ttc ttg gct aat ccc 384 Gly Glu Arg Gln Leu Ile Thr Ile Ala Arg Ala Phe Leu Ala Asn Pro         115 120 125 cga ctg ctg att ctg gat gaa gcc acc tca tcg gtg gat acg cgt acc 432 Arg Leu Leu Ile Leu Asp Glu Ala Thr Ser Ser Val Asp Thr Arg Thr     130 135 140 gaa ttg ttg att cag cgc gcc atg tcc aag ctg cgc caa gac cgc acc 480 Glu Leu Leu Ile Gln Arg Ala Met Ser Lys Leu Arg Gln Asp Arg Thr 145 150 155 160 gcc ttc gtc atc gcg cac cgg ttg tcc acg att cgt gat gcc aac ctg 528 Ala Phe Val Ile Ala His Arg Leu Ser Thr Ile Arg Asp Ala Asn Leu                 165 170 175 att ttg atg atg ag g a g g ggc gag atc gtg gag cag ggc aat cac cgt 576 Ile Leu Met Met Lys Asp Gly Glu Ile Val Glu Gln Gly Asn His Arg             180 185 190 gag ttg atg gcc ctg gag ggc gca tat tgg gag ttg tat aac tcc caa 624 Glu Leu Met Ala Leu Glu Gly Ala Tyr Trp Glu Leu Tyr Asn Ser Gln         195 200 205 ttc aac gcc ccc gcg aaa gaa gaa tta cag gct gac gga gat cac 669 Phe Asn Ala Pro Ala Lys Glu Glu Leu Gln Ala Asp Gly Asp His     210 215 220 tgatgatttc ttcttaggct ttc 692 <210> 340 <211> 223 <212> PRT <213> Corynebacterium glutamicum <400> 340 Gly Pro Thr Gly Ala Gly Lys Thr Thr Leu Val Asn Leu Ile Met Arg   1 5 10 15 Phe Tyr Asp Ile Asn Ser Gly Ser Ile Thr Leu Gly Glu Thr Ala Gln              20 25 30 Asp Ala Val Asp Ile Arg Thr Met Ala Arg Glu Asp Leu Arg Ser Arg          35 40 45 Thr Gly Met Val Leu Gln Asp Thr Trp Leu Phe Ala Gly Thr Ile Arg      50 55 60 Asp Asn Ile Leu Tyr Gly Arg Pro Glu Ala Thr Glu Glu Glu Met Leu  65 70 75 80 Ala Ala Ser Lys Ala Ala Tyr Val Asp Arg Phe Val Arg Ser Leu Pro                  85 90 95 Glu Gly Tyr Asp Thr Val Leu Asp Asp Glu Ala Met Asn Leu Ser Val             100 105 110 Gly Glu Arg Gln Leu Ile Thr Ile Ala Arg Ala Phe Leu Ala Asn Pro         115 120 125 Arg Leu Leu Ile Leu Asp Glu Ala Thr Ser Ser Val Asp Thr Arg Thr     130 135 140 Glu Leu Leu Ile Gln Arg Ala Met Ser Lys Leu Arg Gln Asp Arg Thr 145 150 155 160 Ala Phe Val Ile Ala His Arg Leu Ser Thr Ile Arg Asp Ala Asn Leu                 165 170 175 Ile Leu Met Met Lys Asp Gly Glu Ile Val Glu Gln Gly Asn His Arg             180 185 190 Glu Leu Met Ala Leu Glu Gly Ala Tyr Trp Glu Leu Tyr Asn Ser Gln         195 200 205 Phe Asn Ala Pro Ala Lys Glu Glu Leu Gln Ala Asp Gly Asp His     210 215 220 <210> 341 <211> 1986 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1963) <223> RXA00878 <400> 341 cgagattagg tccgcttcag ttgtggtggc tccgaatctg atgaacaatg atcattccta 60 attcatttac atctttatca aagagagcca ccacctacta atg cga ctt ctt ggt 115                                             Met Arg Leu Leu Gly                                               1 5 cga att tta aaa acc acg tct gcg ctt tgg ccc tac tat ctc gga att 163 Arg Ile Leu Lys Thr Thr Ser Ala Leu Trp Pro Tyr Tyr Leu Gly Ile                  10 15 20 atc gtc gta tcc att gtg atc gcg gcg ttg tcg ctg ctg tcg ccg ttt 211 Ile Val Val Ser Ile Val Ile Ala Ala Leu Ser Leu Leu Ser Pro Phe              25 30 35 att ctc cgc gaa gca aca gat tcc att gtt tct gca gta acc gga tct 259 Ile Leu Arg Glu Ala Thr Asp Ser Ile Val Ser Ala Val Thr Gly Ser          40 45 50 aac acc gtc gat gca gtt act cgc act att att ttc tta gct tta gcc 307 Asn Thr Val Asp Ala Val Thr Arg Thr Ile Ile Phe Leu Ala Leu Ala      55 60 65 ctg ttt gtc gca agc ttc ctc aat acg gtg atg acc aac atc ggt ggc 355 Leu Phe Val Ala Ser Phe Leu Asn Thr Val Met Thr Asn Ile Gly Gly  70 75 80 85 tac atc ggt gat gtc atg gca tct cgt atg cgc cag att ctg gcc acg 403 Tyr Ile Gly Asp Val Met Ala Ser Arg Met Arg Gln Ile Leu Ala Thr                  90 95 100 cgc tat tac gca aag ctg ttg gcg ctg cct cag aag tat ttt gat aat 451 Arg Tyr Tyr Ala Lys Leu Leu Ala Leu Pro Gln Lys Tyr Phe Asp Asn             105 110 115 cag gtc acc ggc acc atc atc gcc cgc ctt gat cga tca atc aac ggc 499 Gln Val Thr Gly Thr Ile Ile Ala Arg Leu Asp Arg Ser Ile Asn Gly         120 125 130 atc acg cag ttc atg cag agc ttc tcc aac aac ttc ttc ccc atg ctc 547 Ile Thr Gln Phe Met Gln Ser Phe Ser Asn Asn Phe Phe Pro Met Leu     135 140 145 atc acc atg gtg gca gtg ctg att att tcc gcg att ttc tac tgg cct 595 Ile Thr Met Val Ala Val Leu Ile Ile Ser Ala Ile Phe Tyr Trp Pro 150 155 160 165 ctg gca att ctg ctg gcc atg ttg ttc ccg att tac atg tgg ctg acg 643 Leu Ala Ile Leu Leu Ala Met Leu Phe Pro Ile Tyr Met Trp Leu Thr                 170 175 180 gcg ttg aca tcg aaa cgc tgg cag aaa tat gag ggc gag aaa aac cat 691 Ala Leu Thr Ser Lys Arg Trp Gln Lys Tyr Glu Gly Glu Lys Asn His             185 190 195 gaa atc gac gtg gct aac ggc cgc ttc gct gag gtt gtc ggc cag gtc 739 Glu Ile Asp Val Ala Asn Gly Arg Phe Ala Glu Val Val Gly Gln Val         200 205 210 aag gtt gtt aaa tca ttc gtc gca gag acc cgc gag ctg gct gat ttc 787 Lys Val Val Lys Ser Phe Val Ala Glu Thr Arg Glu Leu Ala Asp Phe     215 220 225 ggt ggg cgt tac ggc aaa aca gta gcg att acc cgg ccg caa tcc ggt 835 Gly Gly Arg Tyr Gly Lys Thr Val Ala Ile Thr Arg Pro Gln Ser Gly 230 235 240 245 tgg tgg cac cgc atg gat act ctc cgt ggc gcg gca cta aat atc atc 883 Trp Trp His Arg Met Asp Thr Leu Arg Gly Ala Ala Leu Asn Ile Ile                 250 255 260 ttc ctg gcc att cac ctg ctg att ttc tac cgc acc ttg cac ggc cat 931 Phe Leu Ala Ile His Leu Leu Ile Phe Tyr Arg Thr Leu His Gly His             265 270 275 ttc acc atc ggc gac atg gtc atg ctc atc cag ctt gtc acc atg gcg 979 Phe Thr Ile Gly Asp Met Val Met Leu Ile Gln Leu Val Thr Met Ala         280 285 290 cag caa ccg gtg tac atg atg agc tac atc gtc gac tcc gcg cag cgc 1027 Gln Gln Pro Val Tyr Met Met Ser Tyr Ile Val Asp Ser Ala Gln Arg     295 300 305 gcc atc gcc ggc tcc cgc gac tac ttc gag gtc atg gcg cag cag gtc 1075 Ala Ile Ala Gly Ser Arg Asp Tyr Phe Glu Val Met Ala Gln Gln Val 310 315 320 325 gag ccc acc gcc aat aag gag ctt gtc gac gcc acc ctc gcc tca gac 1123 Glu Pro Thr Ala Asn Lys Glu Leu Val Asp Ala Thr Leu Ala Ser Asp                 330 335 340 act cca cgc atc agt gtg ggc acg ccc gcc gcg ctg ccc gct gga gaa 1171 Thr Pro Arg Ile Ser Val Gly Thr Pro Ala Ala Leu Pro Ala Gly Glu             345 350 355 cca gcg atg gaa ttc aaa aac gtc acc ttc gcc tac gaa gaa ggc aag 1219 Pro Ala Met Glu Phe Lys Asn Val Thr Phe Ala Tyr Glu Glu Gly Lys         360 365 370 ccg gtt att tcc gac gtg tcc att acc gcc cgc cac ggc gag cgc atc 1267 Pro Val Ile Ser Asp Val Ser Ile Thr Ala Arg His Gly Glu Arg Ile     375 380 385 gcg ttg gtc ggt gaa tcc ggc ggc ggt aaa tcc acc ctg gtc aac ctt 1315 Ala Leu Val Gly Glu Ser Gly Gly Gly Lys Ser Thr Leu Val Asn Leu 390 395 400 405 ctg tta ggt ctg tac aaa cca aac agc ggc agc ctt gca gta tgt ggc 1363 Leu Leu Gly Leu Tyr Lys Pro Asn Ser Gly Ser Leu Ala Val Cys Gly                 410 415 420 gtg gat gtt aaa gat ctg act tcc gag gaa ctt cgc gca tcc gtg ggt 1411 Val Asp Val Lys Asp Leu Thr Ser Glu Glu Leu Arg Ala Ser Val Gly             425 430 435 gtg gtc ttc cag gac gcc agc ttg ttc tct gga tct att gca gaa aac 1459 Val Val Phe Gln Asp Ala Ser Leu Phe Ser Gly Ser Ile Ala Glu Asn         440 445 450 atc gcc tac ggt cgc cca ggt gcc acc cgc gaa gag atc atc gaa gtg 1507 Ile Ala Tyr Gly Arg Pro Gly Ala Thr Arg Glu Glu Ile Ile Glu Val     455 460 465 gct aag aaa gcc aac gca cat gag ttc att tcc gcc ttc cct gaa gga 1555 Ala Lys Lys Ala Asn Ala His Glu Phe Ile Ser Ala Phe Pro Glu Gly 470 475 480 485 tat gaa acc gtc gtc ggt gaa cgc gga ctc aaa ctt tct ggt ggc cag 1603 Tyr Glu Thr Val Val Gly Glu Arg Gly Leu Lys Leu Ser Gly Gly Gln                 490 495 500 aag cag cgc gtc tct gtg gca cgg gcc atg ctt aaa gat gcc cca ctt 1651 Lys Gln Arg Val Ser Val Ala Arg Ala Met Leu Lys Asp Ala Pro Leu             505 510 515 ctt gtt ctc gat gaa gcc acc tct gca ctg gat acc aag tct gag cag 1699 Leu Val Leu Asp Glu Ala Thr Ser Ala Leu Asp Thr Lys Ser Glu Gln         520 525 530 gca gtc caa gcc ggt ttg gaa cag ctg atg gaa aac cgc acc acc tta 1747 Ala Val Gln Ala Gly Leu Glu Gln Leu Met Glu Asn Arg Thr Thr Leu     535 540 545 atg atc gcc cac cgc ctg tcc acc atc gca ggc gtc gat acc atc gtg 1795 Met Ile Ala His Arg Leu Ser Thr Ile Ala Gly Val Asp Thr Ile Val 550 555 560 565 acc atc caa aac gga cgg gtt gaa gag gtc gga tct cct acc gag ctc 1843 Thr Ile Gln Asn Gly Arg Val Glu Glu Val Gly Ser Pro Thr Glu Leu                 570 575 580 gca gtc tca ggc ggt atc tat tcc gaa ctg ctg cgc ctg acc aac tcc 1891 Ala Val Ser Gly Gly Ile Tyr Ser Glu Leu Leu Arg Leu Thr Asn Ser             585 590 595 aca gca gaa gcc gac cgg gag cgt ctg cgc gcc ttt ggt ttc act ggc 1939 Thr Ala Glu Ala Asp Arg Glu Arg Leu Arg Ala Phe Gly Phe Thr Gly         600 605 610 gat gca cca gct gaa gaa gag gac tagccccgcg aaagaacaat ccc 1986 Asp Ala Pro Ala Glu Glu Glu Asp     615 620 <210> 342 <211> 621 <212> PRT <213> Corynebacterium glutamicum <400> 342 Met Arg Leu Leu Gly Arg Ile Leu Lys Thr Thr Ser Ala Leu Trp Pro   1 5 10 15 Tyr Tyr Leu Gly Ile Ile Val Val Ser Ile Val Ile Ala Ala Leu Ser              20 25 30 Leu Leu Ser Pro Phe Ile Leu Arg Glu Ala Thr Asp Ser Ile Val Ser          35 40 45 Ala Val Thr Gly Ser Asn Thr Val Asp Ala Val Thr Arg Thr Ile Ile      50 55 60 Phe Leu Ala Leu Ala Leu Phe Val Ala Ser Phe Leu Asn Thr Val Met  65 70 75 80 Thr Asn Ile Gly Gly Tyr Ile Gly Asp Val Met Ala Ser Arg Met Arg                  85 90 95 Gln Ile Leu Ala Thr Arg Tyr Tyr Ala Lys Leu Leu Ala Leu Pro Gln             100 105 110 Lys Tyr Phe Asp Asn Gln Val Thr Gly Thr Ile Ila Ala Arg Leu Asp         115 120 125 Arg Ser Ile Asn Gly Ile Thr Gln Phe Met Gln Ser Phe Ser Asn Asn     130 135 140 Phe Phe Pro Met Leu Ile Thr Met Val Ala Val Leu Ile Ile Ser Ala 145 150 155 160 Ile Phe Tyr Trp Pro Leu Ala Ile Leu Leu Ala Met Leu Phe Pro Ile                 165 170 175 Tyr Met Trp Leu Thr Ala Leu Thr Ser Lys Arg Trp Gln Lys Tyr Glu             180 185 190 Gly Glu Lys Asn His Glu Ile Asp Val Ala Asn Gly Arg Phe Ala Glu         195 200 205 Val Val Gly Gln Val Lys Val Val Lys Ser Phe Val Ala Glu Thr Arg     210 215 220 Glu Leu Ala Asp Phe Gly Gly Arg Tyr Gly Lys Thr Val Ala Ile Thr 225 230 235 240 Arg Pro Gln Ser Gly Trp Trp His Arg Met Asp Thr Leu Arg Gly Ala                 245 250 255 Ala Leu Asn Ile Ile Phe Leu Ala Ile His Leu Leu Ile Phe Tyr Arg             260 265 270 Thr Leu His Gly His Phe Thr Ile Gly Asp Met Val Met Leu Ile Gln         275 280 285 Leu Val Thr Met Ala Gln Gln Pro Val Tyr Met Met Ser Tyr Ile Val     290 295 300 Asp Ser Ala Gln Arg Ala Ile Ala Gly Ser Arg Asp Tyr Phe Glu Val 305 310 315 320 Met Ala Gln Gln Val Glu Pro Thr Ala Asn Lys Glu Leu Val Asp Ala                 325 330 335 Thr Leu Ala Ser Asp Thr Pro Arg Ile Ser Val Gly Thr Pro Ala Ala             340 345 350 Leu Pro Ala Gly Glu Pro Ala Met Glu Phe Lys Asn Val Thr Phe Ala         355 360 365 Tyr Glu Glu Gly Lys Pro Val Ile Ser Asp Val Ser Ile Thr Ala Arg     370 375 380 His Gly Glu Arg Ile Ala Leu Val Gly Glu Ser Gly Gly Gly Lys Ser 385 390 395 400 Thr Leu Val Asn Leu Leu Leu Gly Leu Tyr Lys Pro Asn Ser Gly Ser                 405 410 415 Leu Ala Val Cys Gly Val Asp Val Lys Asp Leu Thr Ser Glu Glu Leu             420 425 430 Arg Ala Ser Val Gly Val Val Phe Gln Asp Ala Ser Leu Phe Ser Gly         435 440 445 Ser Ile Ala Glu Asn Ile Ala Tyr Gly Arg Pro Gly Ala Thr Arg Glu     450 455 460 Glu Ile Ile Glu Val Ala Lys Lys Ala Asn Ala His Glu Phe Ile Ser 465 470 475 480 Ala Phe Pro Glu Gly Tyr Glu Thr Val Val Gly Glu Arg Gly Leu Lys                 485 490 495 Leu Ser Gly Gly Gln Lys Gln Arg Val Ser Val Ala Arg Ala Met Leu             500 505 510 Lys Asp Ala Pro Leu Leu Val Leu Asp Glu Ala Thr Ser Ala Leu Asp         515 520 525 Thr Lys Ser Glu Gln Ala Val Gln Ala Gly Leu Glu Gln Leu Met Glu     530 535 540 Asn Arg Thr Thr Leu Met Ile Ala His Arg Leu Ser Thr Ile Ala Gly 545 550 555 560 Val Asp Thr Ile Val Thr Ile Gln Asn Gly Arg Val Glu Glu Val Gly                 565 570 575 Ser Pro Thr Glu Leu Ala Val Ser Gly Gle Ile Tyr Ser Glu Leu Leu             580 585 590 Arg Leu Thr Asn Ser Thr Ala Glu Ala Asp Arg Glu Arg Leu Arg Ala         595 600 605 Phe Gly Phe Thr Gly Asp Ala Pro Ala Glu Glu Glu Asp     610 615 620 <210> 343 <211> 1713 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1690) <223> RXN01191 <400> 343 cgctgctttc acgcaactga aaccgcaccg gatcaagtta tttggggttg ttctttgtgg 60 cgtgttggtg gccgtcgcgg ggttggtagg gccctgggcg gtg ggt gga ctc gtc 115                                             Val Gly Gly Leu Val                                               1 5 gat aag ctc ctt gca acc ccg agc atg cgc gac gtt gta gtg ttc gcg 163 Asp Lys Leu Leu Ala Thr Pro Ser Met Arg Asp Val Val Val Phe Ala                  10 15 20 ctg ctt atc gtg gct ggc ggc gtt gtt tcg agc ctg ggc acg tgg tgg 211 Leu Leu Ile Val Ala Gly Gly Val Val Ser Ser Leu Gly Thr Trp Trp              25 30 35 ggc agc gcg ctg atg gcg cgc gcg ttg gag ccg gcg atc gcg ggg ctg 259 Gly Ser Ala Leu Met Ala Arg Ala Leu Glu Pro Ala Ile Ala Gly Leu          40 45 50 cgc gag gat gtg ttg cgc gcg gcg gtg agt ttg gat gcg aac acg att 307 Arg Glu Asp Val Leu Arg Ala Ala Val Ser Leu Asp Ala Asn Thr Ile      55 60 65 gaa acg gcg ggg cgc ggc gac gtg att tcg cgt atc gcg gat gat tcg 355 Glu Thr Ala Gly Arg Gly Asp Val Ile Ser Arg Ile Ala Asp Asp Ser  70 75 80 85 cgg gag gtg tcc act gcg gcg agc acc gtg gtg ccg ctg atg gtg cag 403 Arg Glu Val Ser Thr Ala Ala Ser Thr Val Val Pro Leu Met Val Gln                  90 95 100 gcg ggc ttt acc gtg gtg att tcc gcg ttt ggc atg gcg gcg gtt gat 451 Ala Gly Phe Thr Val Val Ile Ser Ala Phe Gly Met Ala Ala Val Asp             105 110 115 tgg cgc ctc ggc ctt gtc ggt ttg gtc gcg atc ccg ctg tat tgg acc 499 Trp Arg Leu Gly Leu Val Gly Leu Val Ala Ile Pro Leu Tyr Trp Thr         120 125 130 acg ttg cgc gtc tat tta ccc cgc tca ggt ccg ctt tat acg cgt gag 547 Thr Leu Arg Val Tyr Leu Pro Arg Ser Gly Pro Leu Tyr Thr Arg Glu     135 140 145 cgc gag gcc ttt ggg gtg cgc acg cag cgg ctt gtc ggc gca gtc gaa 595 Arg Glu Ala Phe Gly Val Arg Thr Gln Arg Leu Val Gly Ala Val Glu 150 155 160 165 ggc gcg gaa acc ttg cgc gct ttc cgc gca gaa gat aca gaa tta aag 643 Gly Ala Glu Thr Leu Arg Ala Phe Arg Ala Glu Asp Thr Glu Leu Lys                 170 175 180 cgt atc gac gca gcc tcc ggc gaa gcc cgc gac att tcc att tct gtt 691 Arg Ile Asp Ala Ala Ser Gly Glu Ala Arg Asp Ile Ser Ile Ser Val             185 190 195 ttc agg ttc ctc aca tgg gca ttt tcc cgc aac aac cgc gcg gaa tgc 739 Phe Arg Phe Leu Thr Trp Ala Phe Ser Arg Asn Asn Arg Ala Glu Cys         200 205 210 atc acc ctc gtg ctc atc ttg ggc acc ggc ttt tac ctg gtc aac atc 787 Ile Thr Leu Val Leu Ile Leu Gly Thr Gly Phe Tyr Leu Val Asn Ile     215 220 225 gat ctg gtc acc gtc ggc gca gtc tca acc gcc gca ctg atc ttc cac 835 Asp Leu Val Thr Val Gly Ala Val Ser Thr Ala Ala Leu Ile Phe His 230 235 240 245 cga ctc ttc ggt cca atc ggc acg ctc gtg ggc atg ttc tcc gac atc 883 Arg Leu Phe Gly Pro Ile Gly Thr Leu Val Gly Met Phe Ser Asp Ile                 250 255 260 caa tcc gcc agc gca tcg ctg atc cgc atg gtg ggc gtt att aac gcg 931 Gln Ser Ala Ser Ala Ser Leu Ile Arg Met Val Gly Val Ile Asn Ala             265 270 275 gca tcg aac cag gtc agc ggc acc tcg ccg gcg tct gcc agc acc gct 979 Ala Ser Asn Gln Val Ser Gly Thr Ser Pro Ala Ser Ala Ser Thr Ala         280 285 290 tta acg ctt ttc gac gtc tcc cac cac tat cac act gca ccc gtc atc 1027 Leu Thr Leu Phe Asp Val Ser His His Tyr His Thr Ala Pro Val Ile     295 300 305 aag aat gca tcc gtg cag ctg gaa cca ggg gaa cac atc gcc att gtg 1075 Lys Asn Ala Ser Val Gln Leu Glu Pro Gly Glu His Ile Ala Ile Val 310 315 320 325 ggt gcg acc ggc gct ggt aaa agc acg ctc gcc ctc att gcg gca ggc 1123 Gly Ala Thr Gly Ala Gly Lys Ser Thr Leu Ala Leu Ile Ala Ala Gly                 330 335 340 ctg ctc agc cca act tcc ggg cag gtg gct ctc ggc gga tcg agt ttt 1171 Leu Leu Ser Pro Thr Ser Gly Gln Val Ala Leu Gly Gly Ser Ser Phe             345 350 355 tct aac gtc gaa ccg gaa gca ttg cgc cag aag atc gcg atg gtc agc 1219 Ser Asn Val Glu Pro Glu Ala Leu Arg Gln Lys Ile Ala Met Val Ser         360 365 370 caa gaa atc cac tgc ttc cga gga tct gtt tta gat aat ctt cgt atc 1267 Gln Glu Ile His Cys Phe Arg Gly Ser Val Leu Asp Asn Leu Arg Ile     375 380 385 gca cgc ccc gaa gcc acc gat gcg gac atc cac gcc gtt ctc gcc gat 1315 Ala Arg Pro Glu Ala Thr Asp Ala Asp Ile His Ala Val Leu Ala Asp 390 395 400 405 att ggt gat tcc tgg ttg gag cgc tta ccg caa ggc ata gac acc atc 1363 Ile Gly Asp Ser Trp Leu Glu Arg Leu Pro Gln Gly Ile Asp Thr Ile                 410 415 420 gtg ggt gat ggc gct ttc cgt tta acc tct gtg gaa aac cag atc atg 1411 Val Gly Asp Gly Ala Phe Arg Leu Thr Ser Val Glu Asn Gln Ile Met             425 430 435 gcg ctt gct cgc gta cat ttg gcc gac cta gca atc gtc atc ctt gat 1459 Ala Leu Ala Arg Val His Leu Ala Asp Leu Ala Ile Val Ile Leu Asp         440 445 450 gaa gca acg gct gaa tca ggc tct gat cat gca aaa cag ctt gaa gat 1507 Glu Ala Thr Ala Glu Ser Gly Ser Asp His Ala Lys Gln Leu Glu Asp     455 460 465 gca gcc ctt aaa gtc act gaa aac aga tca gcc atc atc gtg gct cac 1555 Ala Ala Leu Lys Val Thr Glu Asn Arg Ser Ala Ile Ile Val Ala His 470 475 480 485 cgc ctc aac caa gcg aaa acc gcc gat cgc atc atc gtc atg gac tcc 1603 Arg Leu Asn Gln Ala Lys Thr Ala Asp Arg Ile Ile Val Met Asp Ser                 490 495 500 gga gaa atc ata gaa tct gga acc cat gaa gag ctt cga gcg atc ggc 1651 Gly Glu Ile Ile Glu Ser Gly Thr His Glu Glu Leu Arg Ala Ile Gly             505 510 515 ggc cga tat gaa caa ctg tgg act gcg tgg tct gcg cgc taattagcca 1700 Gly Arg Tyr Glu Gln Leu Trp Thr Ala Trp Ser Ala Arg         520 525 530 cccaagacca cgc 1713 <210> 344 <211> 530 <212> PRT <213> Corynebacterium glutamicum <400> 344 Val Gly Gly Leu Val Asp Lys Leu Leu Ala Thr Pro Ser Met Arg Asp   1 5 10 15 Val Val Val Phe Ala Leu Leu Ile Val Ala Gly Gly Val Val Ser Ser              20 25 30 Leu Gly Thr Trp Trp Gly Ser Ala Leu Met Ala Arg Ala Leu Glu Pro          35 40 45 Ala Ile Ala Gly Leu Arg Glu Asp Val Leu Arg Ala Ala Val Ser Leu      50 55 60 Asp Ala Asn Thr Ile Glu Thr Ala Gly Arg Gly Asp Val Ile Ser Arg  65 70 75 80 Ile Ala Asp Asp Ser Arg Glu Val Ser Thr Ala Ala Ser Thr Val Val                  85 90 95 Pro Leu Met Val Gln Ala Gly Phe Thr Val Val Ile Ser Ala Phe Gly             100 105 110 Met Ala Ala Val Asp Trp Arg Leu Gly Leu Val Gly Leu Val Ala Ile         115 120 125 Pro Leu Tyr Trp Thr Thr Leu Arg Val Tyr Leu Pro Arg Ser Gly Pro     130 135 140 Leu Tyr Thr Arg Glu Arg Glu Ala Phe Gly Val Arg Thr Gln Arg Leu 145 150 155 160 Val Gly Ala Val Glu Gly Ala Glu Thr Leu Arg Ala Phe Arg Ala Glu                 165 170 175 Asp Thr Glu Leu Lys Arg Ile Asp Ala Ala Ser Gly Glu Ala Arg Asp             180 185 190 Ile Ser Ile Ser Val Phe Arg Phe Leu Thr Trp Ala Phe Ser Arg Asn         195 200 205 Asn Arg Ala Glu Cys Ile Thr Leu Val Leu Ile Leu Gly Thr Gly Phe     210 215 220 Tyr Leu Val Asn Ile Asp Leu Val Thr Val Gly Ala Val Ser Thr Ala 225 230 235 240 Ala Leu Ile Phe His Arg Leu Phe Gly Pro Ile Gly Thr Leu Val Gly                 245 250 255 Met Phe Ser Asp Ile Gln Ser Ala Ser Ala Ser Leu Ile Arg Met Val             260 265 270 Gly Val Ile Asn Ala Ala Ser Asn Gln Val Ser Gly Thr Ser Pro Ala         275 280 285 Ser Ala Ser Thr Ala Leu Thr Leu Phe Asp Val Ser His His Tyr His     290 295 300 Thr Ala Pro Val Ile Lys Asn Ala Ser Val Gln Leu Glu Pro Gly Glu 305 310 315 320 His Ile Ala Ile Val Gly Ala Thr Gly Ala Gly Lys Ser Thr Leu Ala                 325 330 335 Leu Ile Ala Ala Gly Leu Leu Ser Pro Thr Ser Gly Gln Val Ala Leu             340 345 350 Gly Gly Ser Ser Phe Ser Asn Val Glu Pro Glu Ala Leu Arg Gln Lys         355 360 365 Ile Ala Met Val Ser Gln Glu Ile His Cys Phe Arg Gly Ser Val Leu     370 375 380 Asp Asn Leu Arg Ile Ala Arg Pro Glu Ala Thr Asp Ala Asp Ile His 385 390 395 400 Ala Val Leu Ala Asp Ile Gly Asp Ser Trp Leu Glu Arg Leu Pro Gln                 405 410 415 Gly Ile Asp Thr Ile Val Gly Asp Gly Ala Phe Arg Leu Thr Ser Val             420 425 430 Glu Asn Gln Ile Met Ala Leu Ala Arg Val His Leu Ala Asp Leu Ala         435 440 445 Ile Val Ile Leu Asp Glu Ala Thr Ala Glu Ser Gly Ser Asp His Ala     450 455 460 Lys Gln Leu Glu Asp Ala Ala Leu Lys Val Thr Glu Asn Arg Ser Ala 465 470 475 480 Ile Ile Val Ala His Arg Leu Asn Gln Ala Lys Thr Ala Asp Arg Ile                 485 490 495 Ile Val Met Asp Ser Gly Glu Ile Ile Glu Ser Gly Thr His Glu Glu             500 505 510 Leu Arg Ala Ile Gly Gly Arg Tyr Glu Gln Leu Trp Thr Ala Trp Ser         515 520 525 Ala arg     530 <210> 345 <211> 1430 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (1407) <223> FRXA01191 <400> 345 gtg agt ttg gat gcg aac acg att gaa acg gcg ggg cgc ggc gac gtg 48 Val Ser Leu Asp Ala Asn Thr Ile Glu Thr Ala Gly Arg Gly Asp Val   1 5 10 15 att tcg cgt atc gcg gat gat tcg cgg gag gtg tcc act gcg gcg agc 96 Ile Ser Arg Ile Ala Asp Asp Ser Arg Glu Val Ser Thr Ala Ala Ser              20 25 30 acc gtg gtg ccg ctg atg gtg cag gcg ggc ttt acc gtg gtg att tcc 144 Thr Val Val Pro Leu Met Val Gln Ala Gly Phe Thr Val Val Ile Ser          35 40 45 gcg ttt ggc atg gcg gcg gtt gat tgg cgc ctc ggc ctt gtc ggt ttg 192 Ala Phe Gly Met Ala Ala Val Asp Trp Arg Leu Gly Leu Val Gly Leu      50 55 60 gtc gcg atc ccg ctg tat tgg acc acg ttg cgc gtc tat tta ccc cgc 240 Val Ala Ile Pro Leu Tyr Trp Thr Thr Leu Arg Val Tyr Leu Pro Arg  65 70 75 80 tca ggt ccg ctt tat acg cgt gag cgc gag gcc ttt ggg gtg cgc acg 288 Ser Gly Pro Leu Tyr Thr Arg Glu Arg Glu Ala Phe Gly Val Arg Thr                  85 90 95 cag cgg ctt gtc ggc gca gtc gaa ggc gcg gaa acc ttg cgc gct ttc 336 Gln Arg Leu Val Gly Ala Val Glu Gly Ala Glu Thr Leu Arg Ala Phe             100 105 110 cgc gca gaa gat aca gaa tta aag cgt atc gac gca gcc tcc ggc gaa 384 Arg Ala Glu Asp Thr Glu Leu Lys Arg Ile Asp Ala Ala Ser Gly Glu         115 120 125 gcc cgc gac att tcc att tct gtt ttc agg ttc ctc aca tgg gca ttt 432 Ala Arg Asp Ile Ser Ile Ser Val Phe Arg Phe Leu Thr Trp Ala Phe     130 135 140 tcc cgc aac aac cgc gcg gaa tgc atc acc ctc gtg ctc atc ttg ggc 480 Ser Arg Asn Asn Arg Ala Glu Cys Ile Thr Leu Val Leu Ile Leu Gly 145 150 155 160 acc ggc ttt tac ctg gtc aac atc gat ctg gtc acc gtc ggc gca gtc 528 Thr Gly Phe Tyr Leu Val Asn Ile Asp Leu Val Thr Val Gly Ala Val                 165 170 175 tca acc gcc gca ctg atc ttc cac cga ctc ttc ggt cca atc ggc acg 576 Ser Thr Ala Ala Leu Ile Phe His Arg Leu Phe Gly Pro Ile Gly Thr             180 185 190 ctc gtg ggc atg ttc tcc gac atc caa tcc gcc agc gca tcg ctg atc 624 Leu Val Gly Met Phe Ser Asp Ile Gln Ser Ala Ser Ala Ser Leu Ile         195 200 205 cgc atg gtg ggc gtt att aac gcg gca tcg aac cag gtc agc ggc acc 672 Arg Met Val Gly Val Ile Asn Ala Ala Ser Asn Gln Val Ser Gly Thr     210 215 220 tcg ccg gcg tct gcc agc acc gct tta acg ctt ttc gac gtc tcc cac 720 Ser Pro Ala Ser Ala Ser Thr Ala Leu Thr Leu Phe Asp Val Ser His 225 230 235 240 cac tat cac act gca ccc gtc atc aag aat gca tcc gtg cag ctg gaa 768 His Tyr His Thr Ala Pro Val Ile Lys Asn Ala Ser Val Gln Leu Glu                 245 250 255 cca ggg gaa cac atc gcc att gtg ggt gcg acc ggc gct ggt aaa agc 816 Pro Gly Glu His Ile Ala Ile Val Gly Ala Thr Gly Ala Gly Lys Ser             260 265 270 acg ctc gcc ctc att gcg gca ggc ctg ctc agc cca act tcc ggg cag 864 Thr Leu Ala Leu Ile Ala Ala Gly Leu Leu Ser Pro Thr Ser Gly Gln         275 280 285 gtg gct ctc ggc gga tcg agt ttt tct aac gtc gaa ccg gaa gca ttg 912 Val Ala Leu Gly Gly Ser Ser Phe Ser Asn Val Glu Pro Glu Ala Leu     290 295 300 cgc cag aag atc gcg atg gtc agc caa gaa atc cac tgc ttc cga gga 960 Arg Gln Lys Ile Ala Met Val Ser Gln Glu Ile His Cys Phe Arg Gly 305 310 315 320 tct gtt tta gat aat ctt cgt atc gca cgc ccc gaa gcc acc gat gcg 1008 Ser Val Leu Asp Asn Leu Arg Ile Ala Arg Pro Glu Ala Thr Asp Ala                 325 330 335 gac atc cac gcc gtt ctc gcc gat att ggt gat tcc tgg ttg gag cgc 1056 Asp Ile His Ala Val Leu Ala Asp Ile Gly Asp Ser Trp Leu Glu Arg             340 345 350 tta ccg caa ggc ata gac acc atc gtg ggt gat ggc gct ttc cgt tta 1104 Leu Pro Gln Gly Ile Asp Thr Ile Val Gly Asp Gly Ala Phe Arg Leu         355 360 365 acc tct gtg gaa aac cag atc atg gcg ctt gct cgc gta cat ttg gcc 1152 Thr Ser Val Glu Asn Gln Ile Met Ala Leu Ala Arg Val His Leu Ala     370 375 380 gac cta gca atc gtc atc ctt gat gaa gca acg gct gaa tca ggc tct 1200 Asp Leu Ala Ile Val Ile Leu Asp Glu Ala Thr Ala Glu Ser Gly Ser 385 390 395 400 gat cat gca aaa cag ctt gaa gat gca gcc ctt aaa gtc act gaa aac 1248 Asp His Ala Lys Gln Leu Glu Asp Ala Ala Leu Lys Val Thr Glu Asn                 405 410 415 aga tca gcc atc atc gtg gct cac cgc ctc aac caa gcg aaa acc gcc 1296 Arg Ser Ala Ile Ile Val Ala His Arg Leu Asn Gln Ala Lys Thr Ala             420 425 430 gat cgc atc atc gtc atg gac tcc gga gaa atc ata gaa tct gga acc 1344 Asp Arg Ile Ile Val Met Asp Ser Gly Glu Ile Ile Glu Ser Gly Thr         435 440 445 cat gaa gag ctt cga gcg atc ggc ggt cga tat gaa caa ctg tgg act 1392 His Glu Glu Leu Arg Ala Ile Gly Gly Arg Tyr Glu Gln Leu Trp Thr     450 455 460 gcg tgg tct gcg cgc taattagcca cccaagacca cgc 1430 Ala Trp Ser Ala Arg 465 <210> 346 <211> 469 <212> PRT <213> Corynebacterium glutamicum <400> 346 Val Ser Leu Asp Ala Asn Thr Ile Glu Thr Ala Gly Arg Gly Asp Val   1 5 10 15 Ile Ser Arg Ile Ala Asp Asp Ser Arg Glu Val Ser Thr Ala Ala Ser              20 25 30 Thr Val Val Pro Leu Met Val Gln Ala Gly Phe Thr Val Val Ile Ser          35 40 45 Ala Phe Gly Met Ala Ala Val Asp Trp Arg Leu Gly Leu Val Gly Leu      50 55 60 Val Ala Ile Pro Leu Tyr Trp Thr Thr Leu Arg Val Tyr Leu Pro Arg  65 70 75 80 Ser Gly Pro Leu Tyr Thr Arg Glu Arg Glu Ala Phe Gly Val Arg Thr                  85 90 95 Gln Arg Leu Val Gly Ala Val Glu Gly Ala Glu Thr Leu Arg Ala Phe             100 105 110 Arg Ala Glu Asp Thr Glu Leu Lys Arg Ile Asp Ala Ala Ser Gly Glu         115 120 125 Ala Arg Asp Ile Ser Ile Ser Val Phe Arg Phe Leu Thr Trp Ala Phe     130 135 140 Ser Arg Asn Asn Arg Ala Glu Cys Ile Thr Leu Val Leu Ile Leu Gly 145 150 155 160 Thr Gly Phe Tyr Leu Val Asn Ile Asp Leu Val Thr Val Gly Ala Val                 165 170 175 Ser Thr Ala Ala Leu Ile Phe His Arg Leu Phe Gly Pro Ile Gly Thr             180 185 190 Leu Val Gly Met Phe Ser Asp Ile Gln Ser Ala Ser Ala Ser Leu Ile         195 200 205 Arg Met Val Gly Val Ile Asn Ala Ala Ser Asn Gln Val Ser Gly Thr     210 215 220 Ser Pro Ala Ser Ala Ser Thr Ala Leu Thr Leu Phe Asp Val Ser His 225 230 235 240 His Tyr His Thr Ala Pro Val Ile Lys Asn Ala Ser Val Gln Leu Glu                 245 250 255 Pro Gly Glu His Ile Ala Ile Val Gly Ala Thr Gly Ala Gly Lys Ser             260 265 270 Thr Leu Ala Leu Ile Ala Ala Gly Leu Leu Ser Pro Thr Ser Gly Gln         275 280 285 Val Ala Leu Gly Gly Ser Ser Phe Ser Asn Val Glu Pro Glu Ala Leu     290 295 300 Arg Gln Lys Ile Ala Met Val Ser Gln Glu Ile His Cys Phe Arg Gly 305 310 315 320 Ser Val Leu Asp Asn Leu Arg Ile Ala Arg Pro Glu Ala Thr Asp Ala                 325 330 335 Asp Ile His Ala Val Leu Ala Asp Ile Gly Asp Ser Trp Leu Glu Arg             340 345 350 Leu Pro Gln Gly Ile Asp Thr Ile Val Gly Asp Gly Ala Phe Arg Leu         355 360 365 Thr Ser Val Glu Asn Gln Ile Met Ala Leu Ala Arg Val His Leu Ala     370 375 380 Asp Leu Ala Ile Val Ile Leu Asp Glu Ala Thr Ala Glu Ser Gly Ser 385 390 395 400 Asp His Ala Lys Gln Leu Glu Asp Ala Ala Leu Lys Val Thr Glu Asn                 405 410 415 Arg Ser Ala Ile Ile Val Ala His Arg Leu Asn Gln Ala Lys Thr Ala             420 425 430 Asp Arg Ile Ile Val Met Asp Ser Gly Glu Ile Ile Glu Ser Gly Thr         435 440 445 His Glu Glu Leu Arg Ala Ile Gly Gly Arg Tyr Glu Gln Leu Trp Thr     450 455 460 Ala Trp Ser Ala Arg 465 <210> 347 <211> 1047 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (1024) <223> RXN01212 <400> 347 tttagaagcc acatgacata tgtcatgaaa attatgtgca aagtgcagta atactcctga 60 catatggctc taccagcgcc aatgcgaagt aggaagaatt atg cct atg aca acg 115                                             Met Pro Met Thr Thr                                               1 5 aca cca gca atc gac gta aca gac ctc gtg aga acc tac ggc gac tac 163 Thr Pro Ala Ile Asp Val Thr Asp Leu Val Arg Thr Tyr Gly Asp Tyr                  10 15 20 acc gca gtc aag ggc ctg aat ttc cat gta cag cgc ggt gaa gta ttt 211 Thr Ala Val Lys Gly Leu Asn Phe His Val Gln Arg Gly Glu Val Phe              25 30 35 ggt ctg ctc ggc acc aac ggg gcc ggc aaa acc tcc acc ttg gaa gtc 259 Gly Leu Leu Gly Thr Asn Gly Ala Gly Lys Thr Ser Thr Leu Glu Val          40 45 50 atc gaa gga ctt tcc gca ccc agc tcc ggc acc gtg cgc atc tcc ggg 307 Ile Glu Gly Leu Ser Ala Pro Ser Ser Gly Thr Val Arg Ile Ser Gly      55 60 65 ctt gac ccc gtt gcc gac cgc gcg atc ctg cgc ccc gag ctc ggc atc 355 Leu Asp Pro Val Ala Asp Arg Ala Ile Leu Arg Pro Glu Leu Gly Ile  70 75 80 85 atg ctg caa tca ggc ggc ctg cca tca cag ctc acc gtc gcc gaa acc 403 Met Leu Gln Ser Gly Gly Leu Pro Ser Gln Leu Thr Val Ala Glu Thr                  90 95 100 atg gac atg tgg cac ggc acc tgc acg tat ccg cgc gcc att aaa gat 451 Met Asp Met Trp His Gly Thr Cys Thr Tyr Pro Arg Ala Ile Lys Asp             105 110 115 gtg ctt gcc gac gtc gac ctc cta cac cgc gaa aac gtc aag gtc ggc 499 Val Leu Ala Asp Val Asp Leu Leu His Arg Glu Asn Val Lys Val Gly         120 125 130 gcg ctt tcc gga ggc gaa caa cga cgc ctt gat ttg gcc tgc gca ctg 547 Ala Leu Ser Gly Gly Glu Gln Arg Arg Leu Asp Leu Ala Cys Ala Leu     135 140 145 ctt ggc gac ccc tca att ttg ttc ctc gac gaa ccc acc acc ggc ctc 595 Leu Gly Asp Pro Ser Ile Leu Phe Leu Asp Glu Pro Thr Thr Gly Leu 150 155 160 165 gac cca gaa tct agg cgc cac acc tgg caa ctc ctg ctg gac ctg aaa 643 Asp Pro Glu Ser Arg Arg His Thr Trp Gln Leu Leu Leu Asp Leu Lys                 170 175 180 cag cgc ggc gtc acc atg atg ctg acc acc cac tac ctg gag gaa gcc 691 Gln Arg Gly Val Thr Met Met Leu Thr Thr His Tyr Leu Glu Glu Ala             185 190 195 gaa ttc ctc tgc gac cgg att gcc atc atg aac gcc ggt gag atc gca 739 Glu Phe Leu Cys Asp Arg Ile Ala Ile Met Asn Ala Gly Glu Ile Ala         200 205 210 gtg gaa ggc acc ttg gat gaa ctg gtg gcc cgc gag aag tcg atc atc 787 Val Glu Gly Thr Leu Asp Glu Leu Val Ala Arg Glu Lys Ser Ile Ile     215 220 225 agt ttc gtg ctg cgt ggc ggg cag gtg gag ttg ccg gtc ttg agt ggg 835 Ser Phe Val Leu Arg Gly Gly Gln Val Glu Leu Pro Val Leu Ser Gly 230 235 240 245 gct gaa atc atc cgc gac aac aac cac gtc cgc atc gcc acc acc acc 883 Ala Glu Ile Ile Arg Asp Asn Asn His Val Arg Ile Ala Thr Thr Thr                 250 255 260 ctg cag cag cac acc tta gaa ata ctt acc tgg gct gca gag acc ggg 931 Leu Gln Gln His Thr Leu Glu Ile Leu Thr Trp Ala Ala Glu Thr Gly             265 270 275 atc gcg ctg gaa ggc ttc gct gca aaa ccc gcc acc ttg gaa tcc gta 979 Ile Ala Leu Glu Gly Phe Ala Ala Lys Pro Ala Thr Leu Glu Ser Val         280 285 290 ttc atg gac atc gcc tca ctc gag aac acc tcg ctg caa acc gcc 1024 Phe Met Asp Ile Ala Ser Leu Glu Asn Thr Ser Leu Gln Thr Ala     295 300 305 tagaatcttt aaggagacca caa 1047 <210> 348 <211> 308 <212> PRT <213> Corynebacterium glutamicum <400> 348 Met Pro Met Thr Thr Thr Pro Ala Ile Asp Val Thr Asp Leu Val Arg   1 5 10 15 Thr Tyr Gly Asp Tyr Thr Ala Val Lys Gly Leu Asn Phe His Val Gln              20 25 30 Arg Gly Glu Val Phe Gly Leu Leu Gly Thr Asn Gly Ala Gly Lys Thr          35 40 45 Ser Thr Leu Glu Val Ile Glu Gly Leu Ser Ala Pro Ser Ser Gly Thr      50 55 60 Val Arg Ile Ser Gly Leu Asp Pro Val Ala Asp Arg Ala Ile Leu Arg  65 70 75 80 Pro Glu Leu Gly Ile Met Leu Gln Ser Gly Gly Leu Pro Ser Gln Leu                  85 90 95 Thr Val Ala Glu Thr Met Asp Met Trp His Gly Thr Cys Thr Tyr Pro             100 105 110 Arg Ala Ile Lys Asp Val Leu Ala Asp Val Asp Leu Leu His Arg Glu         115 120 125 Asn Val Lys Val Gly Ala Leu Ser Gly Gly Glu Gln Arg Arg Leu Asp     130 135 140 Leu Ala Cys Ala Leu Leu Gly Asp Pro Ser Ile Leu Phe Leu Asp Glu 145 150 155 160 Pro Thr Thr Gly Leu Asp Pro Glu Ser Arg Arg His Thr Trp Gln Leu                 165 170 175 Leu Leu Asp Leu Lys Gln Arg Gly Val Thr Met Met Leu Thr Thr His             180 185 190 Tyr Leu Glu Glu Ala Glu Phe Leu Cys Asp Arg Ile Ala Ile Met Asn         195 200 205 Ala Gly Glu Ile Ala Val Glu Gly Thr Leu Asp Glu Leu Val Ala Arg     210 215 220 Glu Lys Ser Ile Ile Ser Phe Val Leu Arg Gly Gly Gln Val Glu Leu 225 230 235 240 Pro Val Leu Ser Gly Ala Glu Ile Ile Arg Asp Asn Asn His Val Arg                 245 250 255 Ile Ala Thr Thr Thr Le Le Gln Gln His Thr Leu Glu Ile Leu Thr Trp             260 265 270 Ala Ala Glu Thr Gly Ile Ala Leu Glu Gly Phe Ala Ala Lys Pro Ala         275 280 285 Thr Leu Glu Ser Val Phe Met Asp Ile Ala Ser Leu Glu Asn Thr Ser     290 295 300 Leu Gln Thr Ala 305 <210> 349 <211> 813 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (813) <223> FRXA01212 <400> 349 ggc ctg aat ttc cat gta cag cgc ggt gaa gta ttt ggt ctg ctc ggc 48 Gly Leu Asn Phe His Val Gln Arg Gly Glu Val Phe Gly Leu Leu Gly   1 5 10 15 acc aac ggg gcc ggc aaa acc tcc acc ttg gaa gtc atc gaa gga ctt 96 Thr Asn Gly Ala Gly Lys Thr Ser Thr Leu Glu Val Ile Glu Gly Leu              20 25 30 tcc gca ccc agc tcc ggc acc gtg cgc atc tcc ggg ctt gac ccc gtt 144 Ser Ala Pro Ser Ser Gly Thr Val Arg Ile Ser Gly Leu Asp Pro Val          35 40 45 gcc gac cgc gcg atc ctg cgc ccc gag ctc ggc atc atg ctg caa tca 192 Ala Asp Arg Ala Ile Leu Arg Pro Glu Leu Gly Ile Met Leu Gln Ser      50 55 60 ggc ggc ctg cca tca cag ctc acc gtc gcc gaa acc atg gac atg tgg 240 Gly Gly Leu Pro Ser Gln Leu Thr Val Ala Glu Thr Met Asp Met Trp  65 70 75 80 cac ggc acc tgc acg tat ccg cgc gcc att aaa gat gtg ctt gcc gac 288 His Gly Thr Cys Thr Tyr Pro Arg Ala Ile Lys Asp Val Leu Ala Asp                  85 90 95 gtc gac ctc cta cac cgc gaa aac gtc aag gtc ggc gcg ctt tcc gga 336 Val Asp Leu Leu His Arg Glu Asn Val Lys Val Gly Ala Leu Ser Gly             100 105 110 ggc gaa caa cga cgc ctt gat ttg gcc tgc gca ctg ctt ggc gac ccc 384 Gly Glu Gln Arg Arg Leu Asp Leu Ala Cys Ala Leu Leu Gly Asp Pro         115 120 125 tca att ttg ttc ctc gac gaa ccc acc acc ggc ctc gac cca gaa tct 432 Ser Ile Leu Phe Leu Asp Glu Pro Thr Thr Gly Leu Asp Pro Glu Ser     130 135 140 agg cgc cac acc tgg caa ctc ctg ctg gac ctg aaa cag cgc ggc gtc 480 Arg Arg His Thr Trp Gln Leu Leu Leu Asp Leu Lys Gln Arg Gly Val 145 150 155 160 acc atg atg ctg acc acc cac tac ctg gag gaa gcc gaa ttc ctc tgc 528 Thr Met Met Leu Thr Thr His Tyr Leu Glu Glu Ala Glu Phe Leu Cys                 165 170 175 gac cgg att gcc atc atg aac gcc ggt gag atc gca gtg gaa ggc acc 576 Asp Arg Ile Ala Ile Met Asn Ala Gly Glu Ile Ala Val Glu Gly Thr             180 185 190 ttg gat gaa ctg gtg gcc cgc gag aag tcg atc atc agt ttc gtg ctg 624 Leu Asp Glu Leu Val Ala Arg Glu Lys Ser Ile Ile Ser Phe Val Leu         195 200 205 cgt ggc ggg cag gtg gag ttg ccg gtc ttg agt ggg gct gaa atc atc 672 Arg Gly Gly Gln Val Glu Leu Pro Val Leu Ser Gly Ala Glu Ile Ile     210 215 220 cgc gac aac aac cac gtc cgc atc gcc acc acc ctg cag cag cac 720 Arg Asp Asn Asn His Val Arg Ile Ala Thr Thr Thr Leu Gln Gln His 225 230 235 240 acc tta gaa ata ctt acc tgg gct gca gag acc ggg atc gcg ctg gaa 768 Thr Leu Glu Ile Leu Thr Trp Ala Ala Glu Thr Gly Ile Ala Leu Glu                 245 250 255 ggc ttc gct gca aaa ccc gcc acc ttg gaa tcc gta ttc atg gac 813 Gly Phe Ala Ala Lys Pro Ala Thr Leu Glu Ser Val Phe Met Asp             260 265 270 <210> 350 <211> 271 <212> PRT <213> Corynebacterium glutamicum <400> 350 Gly Leu Asn Phe His Val Gln Arg Gly Glu Val Phe Gly Leu Leu Gly   1 5 10 15 Thr Asn Gly Ala Gly Lys Thr Ser Thr Leu Glu Val Ile Glu Gly Leu              20 25 30 Ser Ala Pro Ser Ser Gly Thr Val Arg Ile Ser Gly Leu Asp Pro Val          35 40 45 Ala Asp Arg Ala Ile Leu Arg Pro Glu Leu Gly Ile Met Leu Gln Ser      50 55 60 Gly Gly Leu Pro Ser Gln Leu Thr Val Ala Glu Thr Met Asp Met Trp  65 70 75 80 His Gly Thr Cys Thr Tyr Pro Arg Ala Ile Lys Asp Val Leu Ala Asp                  85 90 95 Val Asp Leu Leu His Arg Glu Asn Val Lys Val Gly Ala Leu Ser Gly             100 105 110 Gly Glu Gln Arg Arg Leu Asp Leu Ala Cys Ala Leu Leu Gly Asp Pro         115 120 125 Ser Ile Leu Phe Leu Asp Glu Pro Thr Thr Gly Leu Asp Pro Glu Ser     130 135 140 Arg Arg His Thr Trp Gln Leu Leu Leu Asp Leu Lys Gln Arg Gly Val 145 150 155 160 Thr Met Met Leu Thr Thr His Tyr Leu Glu Glu Ala Glu Phe Leu Cys                 165 170 175 Asp Arg Ile Ala Ile Met Asn Ala Gly Glu Ile Ala Val Glu Gly Thr             180 185 190 Leu Asp Glu Leu Val Ala Arg Glu Lys Ser Ile Ile Ser Phe Val Leu         195 200 205 Arg Gly Gly Gln Val Glu Leu Pro Val Leu Ser Gly Ala Glu Ile Ile     210 215 220 Arg Asp Asn Asn His Val Arg Ile Ala Thr Thr Thr Leu Gln Gln His 225 230 235 240 Thr Leu Glu Ile Leu Thr Trp Ala Ala Glu Thr Gly Ile Ala Leu Glu                 245 250 255 Gly Phe Ala Ala Lys Pro Ala Thr Leu Glu Ser Val Phe Met Asp             260 265 270 <210> 351 <211> 999 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (976) <223> RXA02749 <400> 351 caacctagac ttcggtaaga agtaactttg ctttagttgg tcggcgcatc actttcccta 60 agcgatgcgc cgattacttg tttttgctac aaatttaact atg tca ccc atc cta 115                                             Met Ser Pro Ile Leu                                               1 5 aaa gtg cgg gac ctc gtc aaa cgc tat ggc gac acc gtt gcg gtt gac 163 Lys Val Arg Asp Leu Val Lys Arg Tyr Gly Asp Thr Val Ala Val Asp                  10 15 20 ggt tta aat ttt gat gtt tca caa ggg gaa att ttt gcc ttt cta ggg 211 Gly Leu Asn Phe Asp Val Ser Gln Gly Glu Ile Phe Ala Phe Leu Gly              25 30 35 gag aac ggc gca gga aaa aca acc acg att tca tgc ctg att ggc att 259 Glu Asn Gly Ala Gly Lys Thr Thr Thr Thr Ile Ser Cys Leu Ile Gly Ile          40 45 50 gat caa gcc acc tct ggg gag atc gaa ctg cag ggt ggc caa gta gat 307 Asp Gln Ala Thr Ser Gly Glu Ile Glu Leu Gln Gly Gly Gln Val Asp      55 60 65 tct gaa aaa ctt gga gtg gtg ttt caa caa tcc gtc tta gac cct ttg 355 Ser Glu Lys Leu Gly Val Val Phe Gln Gln Ser Val Leu Asp Pro Leu  70 75 80 85 ctg agt gcc aaa gaa aac ttg gaa aca cgc gga cag ctg tac cca ggg 403 Leu Ser Ala Lys Glu Asn Leu Glu Thr Arg Gly Gln Leu Tyr Pro Gly                  90 95 100 gtg ggg aag cag cgg gtt gca cag ctc att gag caa atc ggg atg gaa 451 Val Gly Lys Gln Arg Val Ala Gln Leu Ile Glu Gln Ile Gly Met Glu             105 110 115 ggg ttt gcg gac cgc cga tac gga gtg ttg tcg ggc ggt gaa aaa cgt 499 Gly Phe Ala Asp Arg Arg Tyr Gly Val Leu Ser Gly Gly Glu Lys Arg         120 125 130 cgc acc gac atc gca cga gct tta ctg cac agc cca gac att ctt ttt 547 Arg Thr Asp Ile Ala Arg Ala Leu Leu His Ser Pro Asp Ile Leu Phe     135 140 145 ctt gat gaa ccc aca gca ggc ctc gac ccc aga tca cga cgc caa gtt 595 Leu Asp Glu Pro Thr Ala Gly Leu Asp Pro Arg Ser Arg Arg Gln Val 150 155 160 165 tgg gac acc atc aat tcc ctg cgt aac gat gtg ggc ctc act gtc ttt 643 Trp Asp Thr Ile Asn Ser Leu Arg Asn Asp Val Gly Leu Thr Val Phe                 170 175 180 ttg acc act cac tac atg gaa gaa aca gaa ctg gct gat tca gtt cta 691 Leu Thr Thr His Tyr Met Glu Glu Thr Glu Leu Ala Asp Ser Val Leu             185 190 195 atc att gac cgt ggc aaa gag gtc gca tca gga acc ccg atg gaa ctg 739 Ile Ile Asp Arg Gly Lys Glu Val Ala Ser Gly Thr Pro Met Glu Leu         200 205 210 cgc gcc cgt tac acc aca aca gaa ttg act ctt aga aca aac gac cct 787 Arg Ala Arg Tyr Thr Thr Thr Glu Leu Thr Leu Arg Thr Asn Asp Pro     215 220 225 act cat tcg ggt aaa gag ttg gcc cac ttg agc cca gaa atc gac ggt 835 Thr His Ser Gly Lys Glu Leu Ala His Leu Ser Pro Glu Ile Asp Gly 230 235 240 245 gac cga ctg cgg atc aag ttg gaa aat ggg ctc gaa gct gcg cgc ctg 883 Asp Arg Leu Arg Ile Lys Leu Glu Asn Gly Leu Glu Ala Ala Arg Leu                 250 255 260 gca aca gaa cta gat ggg gtt ctc gac gta gag atc cgc cac ggt tcc 931 Ala Thr Glu Leu Asp Gly Val Leu Asp Val Glu Ile Arg His Gly Ser             265 270 275 atg gac gat gta ttt cta gca gtt aca gct gaa cgg aaa cga tca 976 Met Asp Asp Val Phe Leu Ala Val Thr Ala Glu Arg Lys Arg Ser         280 285 290 tgattacagt tctgacacgc aga 999 <352> 352 <211> 292 <212> PRT <213> Corynebacterium glutamicum <352> 352 Met Ser Pro Ile Leu Lys Val Arg Asp Leu Val Lys Arg Tyr Gly Asp   1 5 10 15 Thr Val Ala Val Asp Gly Leu Asn Phe Asp Val Ser Gln Gly Glu Ile              20 25 30 Phe Ala Phe Leu Gly Glu Asn Gly Ala Gly Lys Thr Thr Thr Ile Ser          35 40 45 Cys Leu Ile Gly Ile Asp Gln Ala Thr Ser Gly Glu Ile Glu Leu Gln      50 55 60 Gly Gly Gln Val Asp Ser Glu Lys Leu Gly Val Val Phe Gln Gln Ser  65 70 75 80 Val Leu Asp Pro Leu Leu Ser Ala Lys Glu Asn Leu Glu Thr Arg Gly                  85 90 95 Gln Leu Tyr Pro Gly Val Gly Lys Gln Arg Val Ala Gln Leu Ile Glu             100 105 110 Gln Ile Gly Met Glu Gly Phe Ala Asp Arg Arg Tyr Gly Val Leu Ser         115 120 125 Gly Gly Glu Lys Arg Arg Thr Asp Ile Ala Arg Ala Leu Leu His Ser     130 135 140 Pro Asp Ile Leu Phe Leu Asp Glu Pro Thr Ala Gly Leu Asp Pro Arg 145 150 155 160 Ser Arg Arg Gln Val Trp Asp Thr Ile Asn Ser Leu Arg Asn Asp Val                 165 170 175 Gly Leu Thr Val Phe Leu Thr Thr His Tyr Met Glu Glu Thr Glu Leu             180 185 190 Ala Asp Ser Val Leu Ile Ile Asp Arg Gly Lys Glu Val Ala Ser Gly         195 200 205 Thr Pro Met Glu Leu Arg Ala Arg Tyr Thr Thr Thr Thr Glu Leu Thr Leu     210 215 220 Arg Thr Asn Asp Pro Thr His Ser Gly Lys Glu Leu Ala His Leu Ser 225 230 235 240 Pro Glu Ile Asp Gly Asp Arg Leu Arg Ile Lys Leu Glu Asn Gly Leu                 245 250 255 Glu Ala Ala Arg Leu Ala Thr Glu Leu Asp Gly Val Leu Asp Val Glu             260 265 270 Ile Arg His Gly Ser Met Asp Asp Val Phe Leu Ala Val Thr Ala Glu         275 280 285 Arg Lys Arg Ser     290 <210> 353 <211> 1920 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (1897) <223> RXA02224 <400> 353 gcttcgtcga ggccggaaaa ccgtcgtcat tacgtcgaac ccgacgtggc acggcgtcgc 60 aaagcagatg caatctgatt tttcggaagg ggtgaagtag atg gcg cag cat gag 115                                             Met Ala Gln His Glu                                               1 5 cgc gtt gcg gat gcg ctg cag ccg gcg tcg ttg gcg gag tcg tgg cgt 163 Arg Val Ala Asp Ala Leu Gln Pro Ala Ser Leu Ala Glu Ser Trp Arg                  10 15 20 gag ctg aaa acg atg cct tcg ggg ccc aag gcc tgg tgg tat gtg agt 211 Glu Leu Lys Thr Met Pro Ser Gly Pro Lys Ala Trp Trp Tyr Val Ser              25 30 35 ttc gtg gtt att agc gtg gtc acg gtc gtg gcg atg gtc ggc acg tcc 259 Phe Val Val Ile Ser Val Val Thr Val Val Ala Met Val Gly Thr Ser          40 45 50 aac ttg ttg ggc tat tcc gtt gat ctg atc aat ggg cag tcg ttg ccg 307 Asn Leu Leu Gly Tyr Ser Val Asp Leu Ile Asn Gly Gln Ser Leu Pro      55 60 65 ctg atc ggt tca gga tcg acc gca atg atc tgg ttg ctt ggt ttg gtg 355 Leu Ile Gly Ser Gly Ser Thr Ala Met Ile Trp Leu Leu Gly Leu Val  70 75 80 85 ggc gct gga att tta gca gaa act gcc ggt cgc gcg ctg ctg caa ttg 403 Gly Ala Gly Ile Leu Ala Glu Thr Ala Gly Arg Ala Leu Leu Gln Leu                  90 95 100 gtg atc aac acc ttg gca cgt cgc ctg tcg gtg gat ctg cgg aaa gct 451 Val Ile Asn Thr Leu Ala Arg Arg Leu Ser Val Asp Leu Arg Lys Ala             105 110 115 gcg ctg tct tcg gcg ttg cgt gca ccg gtt cct gat gtc atg gaa ttg 499 Ala Leu Ser Ser Ala Leu Arg Ala Pro Val Pro Asp Val Met Glu Leu         120 125 130 ggc acg gga aac gtg att agc cgc ctg acg caa gac atc gat aac act 547 Gly Thr Gly Asn Val Ile Ser Arg Leu Thr Gln Asp Ile Asp Asn Thr     135 140 145 gtg cgc atc gtc ggc atg gta ggt gtg cgt ttg gtg atc acc att ttg 595 Val Arg Ile Val Gly Met Val Gly Val Arg Leu Val Ile Thr Ile Leu 150 155 160 165 att ctg ccc agc tcc ttg ttc gcg ttg atg acc att cac tgg acc ttt 643 Ile Leu Pro Ser Ser Leu Phe Ala Leu Met Thr Ile His Trp Thr Phe                 170 175 180 gtg atc ctg ttc atc gca gtg att gtg gtg ctg att ccc agc ggt cgg 691 Val Ile Leu Phe Ile Ala Val Ile Val Val Leu Ile Pro Ser Gly Arg             185 190 195 aaa gcc gtg cga gct att cct tcg gca aca aat att gtg tcc agt acg 739 Lys Ala Val Arg Ala Ile Pro Ser Ala Thr Asn Ile Val Ser Ser Thr         200 205 210 gag gcg cgt cga aac aat ctg ctc ctc gat acg atc cgt ggc att gaa 787 Glu Ala Arg Arg Asn Asn Leu Leu Leu Asp Thr Ile Arg Gly Ile Glu     215 220 225 aca ctg cgt gtg ctc aag ctc ggt gcg tgg ggt gtg cag cgg atg cgc 835 Thr Leu Arg Val Leu Lys Leu Gly Ala Trp Gly Val Gln Arg Met Arg 230 235 240 245 caa gcg tcg tgg act gcg gtg caa gca aca gct gat cgc gcg ccg att 883 Gln Ala Ser Trp Thr Ala Val Gln Ala Thr Ala Asp Arg Ala Pro Ile                 250 255 260 ttc act cgt ctg ctc gcc ctt ggt tcg att gct tat ggc ctg ctg cta 931 Phe Thr Arg Leu Leu Ala Leu Gly Ser Ile Ala Tyr Gly Leu Leu Leu             265 270 275 att ggc gtg ttt ggg ctc agt gcg ttt tgg gtt gcc cag gat gcg atg 979 Ile Gly Val Phe Gly Leu Ser Ala Phe Trp Val Ala Gln Asp Ala Met         280 285 290 agc att gga gcg gca acg gca gca gtt ttc gtg gtt gtg cgc atg gaa 1027 Ser Ile Gly Ala Ala Thr Ala Ala Val Phe Val Val Arg Met Glu     295 300 305 att cac gtg ttc aac gtg ctg ttc ttc gca tcg gaa att cag agt gcg 1075 Ile His Val Phe Asn Val Leu Phe Phe Ala Ser Glu Ile Gln Ser Ala 310 315 320 325 tct act tct ctt ggt cgc gcg gtg tcc ctt gcc cag atg gct cgt cgc 1123 Ser Thr Ser Leu Gly Arg Ala Val Ser Leu Ala Gln Met Ala Arg Arg                 330 335 340 acc gaa cag ctg tct gag tct gcc gat tgc aca gaa cca ccc tcc gtg 1171 Thr Glu Gln Leu Ser Glu Ser Ala Asp Cys Thr Glu Pro Pro Ser Val             345 350 355 act gtg cag gac gtg acg ttt aaa tat ccc ggc ggc gtg gcc att ttg 1219 Thr Val Gln Asp Val Thr Phe Lys Tyr Pro Gly Gly Val Ala Ile Leu         360 365 370 gag gat ttc aat ctg gtc ttg gaa gca gga aca acc aca gcg ctg gtc 1267 Glu Asp Phe Asn Leu Val Leu Glu Ala Gly Thr Thr Thr Ala Leu Val     375 380 385 ggt act tct ggt gcg gga aaa tcc acg ctc gcg ggc gtc att gcg ggg 1315 Gly Thr Ser Gly Ala Gly Lys Ser Thr Leu Ala Gly Val Ile Ala Gly 390 395 400 405 ctg cag cgc cct gat tcc ggc gcc gtt ttg gtc ggg ggc atc aac acc 1363 Leu Gln Arg Pro Asp Ser Gly Ala Val Leu Val Gly Gly Ile Asn Thr                 410 415 420 gcc acc gtc acc gac acg tgg act acc cgc cag gtt gcg ctg atc agc 1411 Ala Thr Val Thr Asp Thr Trp Thr Thr Arg Gln Val Ala Leu Ile Ser             425 430 435 cag gaa gtc cac ctt ttc gca ggc act ctg gca gag gat ctt cgc atg 1459 Gln Glu Val His Leu Phe Ala Gly Thr Leu Ala Glu Asp Leu Arg Met         440 445 450 gcc aat gcg cac gcc acc gac gcg cag ctc cac gca gcg ctc gag tcg 1507 Ala Asn Ala His Ala Thr Asp Ala Gln Leu His Ala Ala Leu Glu Ser     455 460 465 gtc ggg ctc ggg caa atg aca act gct ttt cga cgt ttc ttt cca tcc 1555 Val Gly Leu Gly Gln Met Thr Thr Ala Phe Arg Arg Phe Phe Pro Ser 470 475 480 485 gga tta gac acc aaa att ggc gcc ggc gca gaa gaa ctc acc cct gaa 1603 Gly Leu Asp Thr Lys Ile Gly Ala Gly Ala Glu Glu Leu Thr Pro Glu                 490 495 500 atc caa cag caa atc tct ctt gcc cgc atc gtg ctc cgc aat cca cct 1651 Ile Gln Gln Gln Ile Ser Leu Ala Arg Ile Val Leu Arg Asn Pro Pro             505 510 515 gtg ttg atc atg gat gaa gcc acc agt gaa gcc ggc agc gat gat gcc 1699 Val Leu Ile Met Asp Glu Ala Thr Ser Glu Ala Gly Ser Asp Asp Ala         520 525 530 cgc atg ttg gaa aaa gcc gcc aca gaa atc gca cga aac cgc acc acc 1747 Arg Met Leu Glu Lys Ala Ala Thr Glu Ile Ala Arg Asn Arg Thr Thr     535 540 545 ttg gtt gtt gcg cac cgc ctt gac caa gca gtt gtc gca gat cgc atc 1795 Leu Val Val Ala His Arg Leu Asp Gln Ala Val Val Ala Asp Arg Ile 550 555 560 565 atc gtg atg gaa caa ggc aca atc acc gaa gac ggc act cac cag gaa 1843 Ile Val Met Glu Gln Gly Thr Ile Thr Glu Asp Gly Thr His Gln Glu                 570 575 580 tta ctt gct ttt gag ggc cgc tac gcg cag ctg tat caa cga tgg agt 1891 Leu Leu Ala Phe Glu Gly Arg Tyr Ala Gln Leu Tyr Gln Arg Trp Ser             585 590 595 gct caa tagttcaaat ccaccacaaa ctc 1920 Ala gln <210> 354 <211> 599 <212> PRT <213> Corynebacterium glutamicum <400> 354 Met Ala Gln His Glu Arg Val Ala Asp Ala Leu Gln Pro Ala Ser Leu   1 5 10 15 Ala Glu Ser Trp Arg Glu Leu Lys Thr Met Pro Ser Gly Pro Lys Ala              20 25 30 Trp Trp Tyr Val Ser Phe Val Val Ile Ser Val Val Thr Val Val Ala          35 40 45 Met Val Gly Thr Ser Asn Leu Leu Gly Tyr Ser Val Asp Leu Ile Asn      50 55 60 Gly Gln Ser Leu Pro Leu Ile Gly Ser Gly Ser Thr Ala Met Ile Trp  65 70 75 80 Leu Leu Gly Leu Val Gly Ala Gly Ile Leu Ala Glu Thr Ala Gly Arg                  85 90 95 Ala Leu Leu Gln Leu Val Ile Asn Thr Leu Ala Arg Arg Leu Ser Val             100 105 110 Asp Leu Arg Lys Ala Ala Leu Ser Ser Ala Leu Arg Ala Pro Val Pro         115 120 125 Asp Val Met Glu Leu Gly Thr Gly Asn Val Ile Ser Arg Leu Thr Gln     130 135 140 Asp Ile Asp Asn Thr Val Arg Ile Val Gly Met Val Gly Val Arg Leu 145 150 155 160 Val Ile Thr Ile Leu Ile Leu Pro Ser Ser Leu Phe Ala Leu Met Thr                 165 170 175 Ile His Trp Thr Phe Val Ile Leu Phe Ile Ala Val Ile Val Val Leu             180 185 190 Ile Pro Ser Gly Arg Lys Ala Val Arg Ala Ile Pro Ser Ala Thr Asn         195 200 205 Ile Val Ser Ser Thr Glu Ala Arg Arg Asn Asn Leu Leu Leu Asp Thr     210 215 220 Ile Arg Gly Ile Glu Thr Leu Arg Val Leu Lys Leu Gly Ala Trp Gly 225 230 235 240 Val Gln Arg Met Arg Gln Ala Ser Trp Thr Ala Val Gln Ala Thr Ala                 245 250 255 Asp Arg Ala Pro Ile Phe Thr Arg Leu Leu Ala Leu Gly Ser Ile Ala             260 265 270 Tyr Gly Leu Leu Leu Ile Gly Val Phe Gly Leu Ser Ala Phe Trp Val         275 280 285 Ala Gln Asp Ala Met Ser Ile Gly Ala Ala Thr Ala Ala Val Phe Val     290 295 300 Val Val Arg Met Glu Ile His Val Phe Asn Val Leu Phe Phe Ala Ser 305 310 315 320 Glu Ile Gln Ser Ala Ser Thr Ser Leu Gly Arg Ala Val Ser Leu Ala                 325 330 335 Gln Met Ala Arg Arg Thr Glu Gln Leu Ser Glu Ser Ala Asp Cys Thr             340 345 350 Glu Pro Pro Ser Val Thr Val Gln Asp Val Thr Phe Lys Tyr Pro Gly         355 360 365 Gly Val Ala Ile Leu Glu Asp Phe Asn Leu Val Leu Glu Ala Gly Thr     370 375 380 Thr Thr Ala Leu Val Gly Thr Ser Gly Ala Gly Lys Ser Thr Leu Ala 385 390 395 400 Gly Val Ile Ala Gly Leu Gln Arg Pro Asp Ser Gly Ala Val Leu Val                 405 410 415 Gly Gly Ile Asn Thr Ala Thr Val Thr Asp Thr Trp Thr Thr Arg Gln             420 425 430 Val Ala Leu Ile Ser Gln Glu Val His Leu Phe Ala Gly Thr Leu Ala         435 440 445 Glu Asp Leu Arg Met Ala Asn Ala His Ala Thr Asp Ala Gln Leu His     450 455 460 Ala Ala Leu Glu Ser Val Gly Leu Gly Gln Met Thr Thr Ala Phe Arg 465 470 475 480 Arg Phe Phe Pro Ser Gly Leu Asp Thr Lys Ile Gly Ala Gly Ala Glu                 485 490 495 Glu Leu Thr Pro Glu Ile Gln Gln Gln Ile Ser Leu Ala Arg Ile Val             500 505 510 Leu Arg Asn Pro Pro Val Leu Ile Met Asp Glu Ala Thr Ser Glu Ala         515 520 525 Gly Ser Asp Asp Ala Arg Met Leu Glu Lys Ala Ala Thr Glu Ile Ala     530 535 540 Arg Asn Arg Thr Thr Leu Val Val Ala His Arg Leu Asp Gln Ala Val 545 550 555 560 Val Ala Asp Arg Ile Ile Val Met Glu Gln Gly Thr Ile Thr Glu Asp                 565 570 575 Gly Thr His Gln Glu Leu Leu Ala Phe Glu Gly Arg Tyr Ala Gln Leu             580 585 590 Tyr Gln Arg Trp Ser Ala Gln         595 <210> 355 <211> 1653 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1630) <223> RXN01602 <400> 355 tgcaggccac atgcctccca gtgccgtctc tgcacgttga ttttcccctg ccacgactgg 60 tcgcagggcg actttctagc acttttaaag gaatttttta atg gct aaa acc cat 115                                             Met Ala Lys Thr His                                               1 5 att cgg tta cag gac ctt tcc ctg tca tac acc tca acc ccg tta att 163 Ile Arg Leu Gln Asp Leu Ser Leu Ser Tyr Thr Ser Thr Pro Leu Ile                  10 15 20 acg aag ctc aat atc act gtt tct tct gga cag tgc gca gtg att gtt 211 Thr Lys Leu Asn Ile Thr Val Ser Ser Gly Gln Cys Ala Val Ile Val              25 30 35 ggt gag aat ggt cga ggt aaa acc aca ctt ctg cga gca ctg gct cga 259 Gly Glu Asn Gly Arg Gly Lys Thr Thr Leu Leu Arg Ala Leu Ala Arg          40 45 50 gaa ttc ccg cca tct gca ggt gag att ctc act cat ggc acg gta gca 307 Glu Phe Pro Pro Ser Ala Gly Glu Ile Leu Thr His Gly Thr Val Ala      55 60 65 att gct cat caa cac atg cct gca ggt gat ctg tcc gtc gga gag atc 355 Ile Ala His Gln His Met Pro Ala Gly Asp Leu Ser Val Gly Glu Ile  70 75 80 85 tgt gat gag gca att cgt gat tca aag aat gct ctc gaa gag ctt gag 403 Cys Asp Glu Ala Ile Arg Asp Ser Lys Asn Ala Leu Glu Glu Leu Glu                  90 95 100 aga gct gga gct cta ctt gag aca aac act gcg cac gca ctt gat gga 451 Arg Ala Gly Ala Leu Leu Glu Thr Asn Thr Ala His Ala Leu Asp Gly             105 110 115 tat caa caa gcc ctt gat gcc gct gaa gtg ctt gac gca tgg aac gct 499 Tyr Gln Gln Ala Leu Asp Ala Ala Glu Val Leu Asp Ala Trp Asn Ala         120 125 130 gaa cat cga tta gaa aaa gct ctg cgc agc ttt ggc gcg atc acc gat 547 Glu His Arg Leu Glu Lys Ala Leu Arg Ser Phe Gly Ala Ile Thr Asp     135 140 145 aga tcc cgt gca ctc agt gag cta tcg atc ggg caa agg tat cgg gta 595 Arg Ser Arg Ala Leu Ser Glu Leu Ser Ile Gly Gln Arg Tyr Arg Val 150 155 160 165 cgg ctg gcc tgc ctc atc ggt ggc gat gct gat att ttg ctt ctc gat 643 Arg Leu Ala Cys Leu Ile Gly Gly Asp Ala Asp Ile Leu Leu Leu Asp                 170 175 180 gaa ccc acc aat cat ctt gac cgg ggc gcg ctt aac tat ctc acc gaa 691 Glu Pro Thr Asn His Leu Asp Arg Gly Ala Leu Asn Tyr Leu Thr Glu             185 190 195 gcc ata acc tcc cac aaa ggt gtg gta ctt gtt gtt tct cat gat caa 739 Ala Ile Thr Ser His Lys Gly Val Val Leu Val Val Ser His Asp Gln         200 205 210 gca ctg atc aaa gat gtc gcg gat ttc atc atc gat att gat tca acc 787 Ala Leu Ile Lys Asp Val Ala Asp Phe Ile Ile Asp Ile Asp Ser Thr     215 220 225 cca gac ggc cta cca cgg atc tat cat gag ggt ttt gat tct tat cga 835 Pro Asp Gly Leu Pro Arg Ile Tyr His Glu Gly Phe Asp Ser Tyr Arg 230 235 240 245 cgc caa agg agt gcg ctt ctt gaa act tgg agg cag gat tat gcc gct 883 Arg Gln Arg Ser Ala Leu Leu Glu Thr Trp Arg Gln Asp Tyr Ala Ala                 250 255 260 gca caa act gtg caa cag caa ttg cag gag gat cta gag cac gca cgc 931 Ala Gln Thr Val Gln Gln Gln Leu Gln Glu Asp Leu Glu His Ala Arg             265 270 275 cag cgg gtg aat tct tcg tgg aaa cct cca aaa gga acg gga aaa cac 979 Gln Arg Val Asn Ser Ser Trp Lys Pro Pro Lys Gly Thr Gly Lys His         280 285 290 act cgc gca tct cgg gct ccc gga gtg gtg cag gcc tta aag cga gca 1027 Thr Arg Ala Ser Arg Ala Pro Gly Val Val Gln Ala Leu Lys Arg Ala     295 300 305 cag gat gcg ttg gat agc aaa gcg ttg gac gtt ccc ccg gct ccg gcc 1075 Gln Asp Ala Leu Asp Ser Lys Ala Leu Asp Val Pro Pro Ala Pro Ala 310 315 320 325 cca ttg ctt ctg cct acc ttg aaa gtg cga cca gat aaa ccc atg gtg 1123 Pro Leu Leu Leu Pro Thr Leu Lys Val Arg Pro Asp Lys Pro Met Val                 330 335 340 gac ttt tcg gac ctt ttt gta ccc cac cgc ttg cgt ctg cca ggc tca 1171 Asp Phe Ser Asp Leu Phe Val Pro His Arg Leu Arg Leu Pro Gly Ser             345 350 355 cat tca gtg gta tca ggt gac aaa ata gtg atc act ggt gac aac ggc 1219 His Ser Val Val Ser Gly Asp Lys Ile Val Ile Thr Gly Asp Asn Gly         360 365 370 gct ggc aaa tca acg ctc atc gaa gtc ttg tct ggg gtt ttg act ccg 1267 Ala Gly Lys Ser Thr Leu Ile Glu Val Leu Ser Gly Val Leu Thr Pro     375 380 385 gca agt ggt tcg gtt gca aac cat gcc cga act ggg gtt ctc ggc caa 1315 Ala Ser Gly Ser Val Ala Asn His Ala Arg Thr Gly Val Leu Gly Gln 390 395 400 405 gaa tca ctt gtc ggc gag gtg cca tca ata gca cga gat cac gca gtt 1363 Glu Ser Leu Val Gly Glu Val Pro Ser Ile Ala Arg Asp His Ala Val                 410 415 420 aag tgg gga ctt tta agt gtt gag gag agc cga ttt gcc cta cag gaa 1411 Lys Trp Gly Leu Leu Ser Val Glu Glu Ser Arg Phe Ala Leu Gln Glu             425 430 435 ttc tca att ggt caa cgc aga aga cta gat ttg gcc atg tcg tta gct 1459 Phe Ser Ile Gly Gln Arg Arg Arg Leu Asp Leu Ala Met Ser Leu Ala         440 445 450 ggc aat cct gaa ctg ttg ctt ctc gat gaa cct tcg aac cat ctg tct 1507 Gly Asn Pro Glu Leu Leu Leu Leu Asp Glu Pro Ser Asn His Leu Ser     455 460 465 atg cac ttg gtt tcc gca ctt aca gag tgg ctg gac acg acc gcg gct 1555 Met His Leu Val Ser Ala Leu Thr Glu Trp Leu Asp Thr Thr Ala Ala 470 475 480 485 gca gtg atc atg gta acg cat gat cga cag cta ctc cgc gat acg gct 1603 Ala Val Ile Met Val Thr His Asp Arg Gln Leu Leu Arg Asp Thr Ala                 490 495 500 cat tgg agg cac atc gag ttg aaa tct taagaattcg caagggcttt 1650 His Trp Arg His Ile Glu Leu Lys Ser             505 510 cac 1653 <210> 356 <211> 510 <212> PRT <213> Corynebacterium glutamicum <400> 356 Met Ala Lys Thr His Ile Arg Leu Gln Asp Leu Ser Leu Ser Tyr Thr   1 5 10 15 Ser Thr Pro Leu Ile Thr Lys Leu Asn Ile Thr Val Ser Ser Gly Gln              20 25 30 Cys Ala Val Ile Val Gly Glu Asn Gly Arg Gly Lys Thr Thr Leu Leu          35 40 45 Arg Ala Leu Ala Arg Glu Phe Pro Pro Ser Ala Gly Glu Ile Leu Thr      50 55 60 His Gly Thr Val Ala Ile Ala His Gln His Met Pro Ala Gly Asp Leu  65 70 75 80 Ser Val Gly Glu Ile Cys Asp Glu Ala Ile Arg Asp Ser Lys Asn Ala                  85 90 95 Leu Glu Glu Leu Glu Arg Ala Gly Ala Leu Leu Glu Thr Asn Thr Ala             100 105 110 His Ala Leu Asp Gly Tyr Gln Gln Ala Leu Asp Ala Ala Glu Val Leu         115 120 125 Asp Ala Trp Asn Ala Glu His Arg Leu Glu Lys Ala Leu Arg Ser Phe     130 135 140 Gly Ala Ile Thr Asp Arg Ser Arg Ala Leu Ser Glu Leu Ser Ile Gly 145 150 155 160 Gln Arg Tyr Arg Val Arg Leu Ala Cys Leu Ile Gly Gly Asp Ala Asp                 165 170 175 Ile Leu Leu Leu Asp Glu Pro Thr Asn His Leu Asp Arg Gly Ala Leu             180 185 190 Asn Tyr Leu Thr Glu Ala Ile Thr Ser His Lys Gly Val Val Leu Val         195 200 205 Val Ser His Asp Gln Ala Leu Ile Lys Asp Val Ala Asp Phe Ile Ile     210 215 220 Asp Ile Asp Ser Thr Pro Asp Gly Leu Pro Arg Ile Tyr His Glu Gly 225 230 235 240 Phe Asp Ser Tyr Arg Arg Gln Arg Ser Ala Leu Leu Glu Thr Trp Arg                 245 250 255 Gln Asp Tyr Ala Ala Ala Gln Thr Val Gln Gln Gln Leu Gln Glu Asp             260 265 270 Leu Glu His Ala Arg Gln Arg Val Asn Ser Ser Trp Lys Pro Pro Lys         275 280 285 Gly Thr Gly Lys His Thr Arg Ala Ser Arg Ala Pro Gly Val Val Gln     290 295 300 Ala Leu Lys Arg Ala Gln Asp Ala Leu Asp Ser Lys Ala Leu Asp Val 305 310 315 320 Pro Pro Ala Pro Ala Pro Leu Leu Leu Pro Thr Leu Lys Val Arg Pro                 325 330 335 Asp Lys Pro Met Val Asp Phe Ser Asp Leu Phe Val Pro His Arg Leu             340 345 350 Arg Leu Pro Gly Ser His Ser Val Val Ser Gly Asp Lys Ile Val Ile         355 360 365 Thr Gly Asp Asn Gly Ala Gly Lys Ser Thr Leu Ile Glu Val Leu Ser     370 375 380 Gly Val Leu Thr Pro Ala Ser Gly Ser Val Ala Asn His Ala Arg Thr 385 390 395 400 Gly Val Leu Gly Gln Glu Ser Leu Val Gly Glu Val Pro Ser Ile Ala                 405 410 415 Arg Asp His Ala Val Lys Trp Gly Leu Leu Ser Val Glu Glu Ser Arg             420 425 430 Phe Ala Leu Gln Glu Phe Ser Ile Gly Gln Arg Arg Arg Leu Asp Leu         435 440 445 Ala Met Ser Leu Ala Gly Asn Pro Glu Leu Leu Leu Leu Asp Glu Pro     450 455 460 Ser Asn His Leu Ser Met His Leu Val Ser Ala Leu Thr Glu Trp Leu 465 470 475 480 Asp Thr Thr Ala Ala Ala Val Ile Met Val Thr His Asp Arg Gln Leu                 485 490 495 Leu Arg Asp Thr Ala His Trp Arg His Ile Glu Leu Lys Ser             500 505 510 <210> 357 <211> 879 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (856) <223> RXN02515 <400> 357 gtggctaagc acagttactt ggccaagctg ggcggcagaa aaaccggccc agctaatact 60 tcagtttaaa attcgcttca accctgaaag attgtgacag atg agc act ctt gaa 115                                             Met Ser Thr Leu Glu                                               1 5 atc cgt aac ctg cac gca cag gtc ctg ccg tcc gat gag tcc gct gag 163 Ile Arg Asn Leu His Ala Gln Val Leu Pro Ser Asp Glu Ser Ala Glu                  10 15 20 cct aag gaa atc ctc aag ggc gtc aac ctc acc atc aac tct ggt gag 211 Pro Lys Glu Ile Leu Lys Gly Val Asn Leu Thr Ile Asn Ser Gly Glu              25 30 35 atc cac gcc atc atg ggc cct aac ggt tcc ggc aag tcc act ctt gct 259 Ile His Ala Ile Met Gly Pro Asn Gly Ser Gly Lys Ser Thr Leu Ala          40 45 50 tac acc ctt ggt gga cac cca cgc tac gag gta acc gca ggc gag gtc 307 Tyr Thr Leu Gly Gly His Pro Arg Tyr Glu Val Thr Ala Gly Glu Val      55 60 65 ctc ctc gac ggc gag aac atc ctg gag atg gaa gtt gat gag cgt gca 355 Leu Leu Asp Gly Glu Asn Ile Leu Glu Met Glu Val Asp Glu Arg Ala  70 75 80 85 cgc gct ggt ctc ttc ctg gcc atg cag tat cca act gaa atc cct ggc 403 Arg Ala Gly Leu Phe Leu Ala Met Gln Tyr Pro Thr Glu Ile Pro Gly                  90 95 100 gtt tcc gtt gct aac ttc ctg cgt tcc gca gcg acc gca atc cgc ggc 451 Val Ser Val Ala Asn Phe Leu Arg Ser Ala Ala Thr Ala Ile Arg Gly             105 110 115 gag gct cct aag ctt cgc gag tgg gtt aag gaa gtc cgc acc gct cag 499 Glu Ala Pro Lys Leu Arg Glu Trp Val Lys Glu Val Arg Thr Ala Gln         120 125 130 gaa gct ctg gca att gac cct gag ttc tcc aac cgc tca gtc aac gaa 547 Glu Ala Leu Ala Ile Asp Pro Glu Phe Ser Asn Arg Ser Val Asn Glu     135 140 145 ggt ttc tcc ggt ggc gag aag aag cgc cac gag gtt ctg cag ctt gat 595 Gly Phe Ser Gly Gly Glu Lys Lys Arg His Glu Val Leu Gln Leu Asp 150 155 160 165 ctg ctg aag cca aag ttc gcg atc atg gat gag acc gac tcc ggc ctt 643 Leu Leu Lys Pro Lys Phe Ala Ile Met Asp Glu Thr Asp Ser Gly Leu                 170 175 180 gac gtg gat gca ctg cgc att gtt tcc gag ggc atc aac tcc tac aag 691 Asp Val Asp Ala Leu Arg Ile Val Ser Glu Gly Ile Asn Ser Tyr Lys             185 190 195 cag gag acc gaa ggt ggc atc ttg atg atc acc cac tac aag cgc atc 739 Gln Glu Thr Glu Gly Gly Ile Leu Met Ile Thr His Tyr Lys Arg Ile         200 205 210 ctc aac tac gtt aag cct gac ttc att cac gtt ttc gcg aat ggc cag 787 Leu Asn Tyr Val Lys Pro Asp Phe Ile His Val Phe Ala Asn Gly Gln     215 220 225 att gtg acc acc ggt ggc gct gag ctt gct gac aag ctc gag gct gac 835 Ile Val Thr Thr Gly Gly Ala Glu Leu Ala Asp Lys Leu Glu Ala Asp 230 235 240 245 ggc tac gac cag ttc atc aag taacatgtcc gatttcctca atg 879 Gly Tyr Asp Gln Phe Ile Lys                 250 <210> 358 <211> 252 <212> PRT <213> Corynebacterium glutamicum <400> 358 Met Ser Thr Leu Glu Ile Arg Asn Leu His Ala Gln Val Leu Pro Ser   1 5 10 15 Asp Glu Ser Ala Glu Pro Lys Glu Ile Leu Lys Gly Val Asn Leu Thr              20 25 30 Ile Asn Ser Gly Glu Ile His Ala Ile Met Gly Pro Asn Gly Ser Gly          35 40 45 Lys Ser Thr Leu Ala Tyr Thr Leu Gly Gly His Pro Arg Tyr Glu Val      50 55 60 Thr Ala Gly Glu Val Leu Leu Asp Gly Glu Asn Ile Leu Glu Met Glu  65 70 75 80 Val Asp Glu Arg Ala Arg Ala Gly Leu Phe Leu Ala Met Gln Tyr Pro                  85 90 95 Thr Glu Ile Pro Gly Val Ser Val Ala Asn Phe Leu Arg Ser Ala Ala             100 105 110 Thr Ala Ile Arg Gly Glu Ala Pro Lys Leu Arg Glu Trp Val Lys Glu         115 120 125 Val Arg Thr Ala Gln Glu Ala Leu Ala Ile Asp Pro Glu Phe Ser Asn     130 135 140 Arg Ser Val Asn Glu Gly Phe Ser Gly Gly Glu Lys Lys Arg His Glu 145 150 155 160 Val Leu Gln Leu Asp Leu Leu Lys Pro Lys Phe Ala Ile Met Asp Glu                 165 170 175 Thr Asp Ser Gly Leu Asp Val Asp Ala Leu Arg Ile Val Ser Glu Gly             180 185 190 Ile Asn Ser Tyr Lys Gln Glu Thr Glu Gly Gly Ile Leu Met Ile Thr         195 200 205 His Tyr Lys Arg Ile Leu Asn Tyr Val Lys Pro Asp Phe Ile His Val     210 215 220 Phe Ala Asn Gly Gln Ile Val Thr Thr Gly Gly Ala Glu Leu Ala Asp 225 230 235 240 Lys Leu Glu Ala Asp Gly Tyr Asp Gln Phe Ile Lys                 245 250 <210> 359 <211> 1386 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (101) .. (1363) <223> RXN00525 <400> 359 ccatcgtgtt tattactcac aaccctgagc ttgctgatga atctgatcgg gtggtcacca 60 tggttgacgg gcgcatcatt gggtctgagg tgaaacactc atg agc ctt gca gaa 115                                             Met Ser Leu Ala Glu                                               1 5 tca att ctt ttg gcg ctc acc agc ctg aga agc aac aag atg cgt gca 163 Ser Ile Leu Leu Ala Leu Thr Ser Leu Arg Ser Asn Lys Met Arg Ala                  10 15 20 ttg ttg acg ctg tta gga gtc atc att ggt atc gca tca gtc atc gga 211 Leu Leu Thr Leu Leu Gly Val Ile Ile Gly Ile Ala Ser Val Ile Gly              25 30 35 att ttg acc att ggt aaa gcc ctg cag gat caa act ttg aat agt ttg 259 Ile Leu Thr Ile Gly Lys Ala Leu Gln Asp Gln Thr Leu Asn Ser Leu          40 45 50 gaa agc ttg ggc gcg aat gat ctg tcg gcg cag gtg gag gaa cgc ccc 307 Glu Ser Leu Gly Ala Asn Asp Leu Ser Ala Gln Val Glu Glu Arg Pro      55 60 65 gac gaa gat tcc ccc gaa ccc gat atg ttc gct ttt tct ggg gct gca 355 Asp Glu Asp Ser Pro Glu Pro Asp Met Phe Ala Phe Ser Gly Ala Ala  70 75 80 85 aac tct agt ggc aat ctg att ccg gaa gaa aca gtt gat acg ctg cgc 403 Asn Ser Ser Gly Asn Leu Ile Pro Glu Glu Thr Val Asp Thr Leu Arg                  90 95 100 gat cgt ttc gca ggc agc atc acg gga atc agc gtt ggc gga atg ggt 451 Asp Arg Phe Ala Gly Ser Ile Thr Gly Ile Ser Val Gly Gly Met Gly             105 110 115 acg caa ggc act ctc atc ggc gac acc gca gat ctt aaa tcc gat ctc 499 Thr Gln Gly Thr Leu Ile Gly Asp Thr Ala Asp Leu Lys Ser Asp Leu         120 125 130 ctc ggc gtc aac gag gat tat atg tgg atg aat ggc gtc gaa atg aac 547 Leu Gly Val Asn Glu Asp Tyr Met Trp Met Asn Gly Val Glu Met Asn     135 140 145 tac ggc cgc gcc atc acg caa gac gat gtt gcc gct cag cgc ccc gtt 595 Tyr Gly Arg Ala Ile Thr Gln Asp Asp Val Ala Ala Gln Arg Pro Val 150 155 160 165 gcg gtc atc gcc cca gac acc ttt aat acg ctt ttc gac gca aac ccc 643 Ala Val Ile Ala Pro Asp Thr Phe Asn Thr Leu Phe Asp Ala Asn Pro                 170 175 180 aac ctc gct ctg ggg tcc gaa gta gct ttt gaa ctc aac ggt caa gag 691 Asn Leu Ala Leu Gly Ser Glu Val Ala Phe Glu Leu Asn Gly Gln Glu             185 190 195 aca ttt ttg cgg gtt atc ggt gtg tat aaa gaa gcc gca gca ggt gga 739 Thr Phe Leu Arg Val Ile Gly Val Tyr Lys Glu Ala Ala Ala Gly Gly         200 205 210 ctt gtg gga agc aat cca acc gtc cac acc tac acc cca tat acg gtg 787 Leu Val Gly Ser Asn Pro Thr Val His Thr Tyr Thr Pro Tyr Thr Val     215 220 225 gcc aat gac atc acc cac acg gaa gat gga ttg aac acg tta agt atc 835 Ala Asn Asp Ile Thr His Thr Glu Asp Gly Leu Asn Thr Leu Ser Ile 230 235 240 245 cgt gca gct cag ggc gta gac cag gat tca ctt aag ggt tca ctg caa 883 Arg Ala Ala Gln Gly Val Asp Gln Asp Ser Leu Lys Gly Ser Leu Gln                 250 255 260 acc tac ttc gac gcg ctg tac gcc aac aat gac tcg cac cac gtt gcc 931 Thr Tyr Phe Asp Ala Leu Tyr Ala Asn Asn Asp Ser His His Val Ala             265 270 275 atg ttg gac ttc cgt aaa cag atc gaa gag ttc aac acc att ctc ggc 979 Met Leu Asp Phe Arg Lys Gln Ile Glu Glu Phe Asn Thr Ile Leu Gly         280 285 290 gca atg agt ttg ggt atc tca gcc atc ggc gga att tcc ttg ctt gtc 1027 Ala Met Ser Leu Gly Ile Ser Ala Ile Gly Gly Ile Ser Leu Leu Val     295 300 305 ggt ggc atc gga gtg atg aac att atg ttg gtg tct gtc acc gag cga 1075 Gly Gly Ile Gly Val Met Asn Ile Met Leu Val Ser Val Thr Glu Arg 310 315 320 325 acc cgc gaa atc ggt gtc cga aaa gcc ctc ggc gct cgt cga cgt gac 1123 Thr Arg Glu Ile Gly Val Arg Lys Ala Leu Gly Ala Arg Arg Arg Asp                 330 335 340 att cgc ctg caa ttc gtc gtt gaa gcc atg atc att tgt ttc atc ggt 1171 Ile Arg Leu Gln Phe Val Val Glu Ala Met Ile Ile Cys Phe Ile Gly             345 350 355 ggc atc ctc ggc gtg ctt ttg ggc ggc att ttg gga ttg atc atg tcc 1219 Gly Ile Leu Gly Val Leu Leu Gly Gly Ile Leu Gly Leu Ile Met Ser         360 365 370 agc gct att ggc tac att tcc ttg cca cca ctg agt gga atc gtg atc 1267 Ser Ala Ile Gly Tyr Ile Ser Leu Pro Pro Leu Ser Gly Ile Val Ile     375 380 385 gcc ttg gta ttt tcc atg gct atc ggc ctg ttt ttc ggc tac tac ccc 1315 Ala Leu Val Phe Ser Met Ala Ile Gly Leu Phe Phe Gly Tyr Tyr Pro 390 395 400 405 gcc aac aag gca gca aag ctc gat cca att gac gcc ttg cgt tat gag 1363 Ala Asn Lys Ala Ala Lys Leu Asp Pro Ile Asp Ala Leu Arg Tyr Glu                 410 415 420 taaaagcctc gtttttaagg tag 1386 <210> 360 <211> 421 <212> PRT <213> Corynebacterium glutamicum <400> 360 Met Ser Leu Ala Glu Ser Ile Leu Leu Ala Leu Thr Ser Leu Arg Ser   1 5 10 15 Asn Lys Met Arg Ala Leu Leu Thr Leu Leu Gly Val Ile Gly Ile              20 25 30 Ala Ser Val Ile Gly Ile Leu Thr Ile Gly Lys Ala Leu Gln Asp Gln          35 40 45 Thr Leu Asn Ser Leu Glu Ser Leu Gly Ala Asn Asp Leu Ser Ala Gln      50 55 60 Val Glu Glu Arg Pro Asp Glu Asp Ser Pro Glu Pro Asp Met Phe Ala  65 70 75 80 Phe Ser Gly Ala Ala Asn Ser Ser Gly Asn Leu Ile Pro Glu Glu Thr                  85 90 95 Val Asp Thr Leu Arg Asp Arg Phe Ala Gly Ser Ile Thr Gly Ile Ser             100 105 110 Val Gly Gly Met Gly Thr Gln Gly Thr Leu Ile Gly Asp Thr Ala Asp         115 120 125 Leu Lys Ser Asp Leu Leu Gly Val Asn Glu Asp Tyr Met Trp Met Asn     130 135 140 Gly Val Glu Met Asn Tyr Gly Arg Ala Ile Thr Gln Asp Asp Val Ala 145 150 155 160 Ala Gln Arg Pro Val Ala Val Ile Ala Pro Asp Thr Phe Asn Thr Leu                 165 170 175 Phe Asp Ala Asn Pro Asn Leu Ala Leu Gly Ser Glu Val Ala Phe Glu             180 185 190 Leu Asn Gly Gln Glu Thr Phe Leu Arg Val Ile Gly Val Tyr Lys Glu         195 200 205 Ala Ala Ala Gly Gly Leu Val Gly Ser Asn Pro Thr Val His Thr Tyr     210 215 220 Thr Pro Tyr Thr Val Ala Asn Asp Ile Thr His Thr Glu Asp Gly Leu 225 230 235 240 Asn Thr Leu Ser Ile Arg Ala Ala Gln Gly Val Asp Gln Asp Ser Leu                 245 250 255 Lys Gly Ser Leu Gln Thr Tyr Phe Asp Ala Leu Tyr Ala Asn Asn Asp             260 265 270 Ser His His Val Ala Met Leu Asp Phe Arg Lys Gln Ile Glu Glu Phe         275 280 285 Asn Thr Ile Leu Gly Ala Met Ser Leu Gly Ile Ser Ala Ile Gly Gly     290 295 300 Ile Ser Leu Leu Val Gly Gly Ile Gly Val Met Asn Ile Met Leu Val 305 310 315 320 Ser Val Thr Glu Arg Thr Arg Glu Ile Gly Val Arg Lys Ala Leu Gly                 325 330 335 Ala Arg Arg Arg Asp Ile Arg Leu Gln Phe Val Val Glu Ala Met Ile             340 345 350 Ile Cys Phe Ile Gly Gly Ile Leu Gly Val Leu Leu Gly Gly Ile Leu         355 360 365 Gly Leu Ile Met Ser Ser Ala Ile Gly Tyr Ile Ser Leu Pro Pro Leu     370 375 380 Ser Gly Ile Val Ile Ala Leu Val Phe Ser Met Ala Ile Gly Leu Phe 385 390 395 400 Phe Gly Tyr Tyr Pro Ala Asn Lys Ala Ala Lys Leu Asp Pro Ile Asp                 405 410 415 Ala Leu Arg Tyr Glu             420 <210> 361 <211> 1815 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1792) <223> RXN02096 <400> 361 cgcttcgacg acctcaccca cagcgatatc cgcaggaatc tcatcgcggt ttttgatgag 60 ccgttcttgt actcctcctc cataccgcga gaacatctcg atg ggt ttg gat gtc 115                                             Met Gly Leu Asp Val                                               1 5 agt gat gag cag atc gaa cac gca gcc agg ctt gcc cag gct cat gat 163 Ser Asp Glu Gln Ile Glu His Ala Ala Arg Leu Ala Gln Ala His Asp                  10 15 20 ttt atc gat cgc ctt cca aac aaa tac gag gaa gtc att ggc gaa cgc 211 Phe Ile Asp Arg Leu Pro Asn Lys Tyr Glu Glu Val Ile Gly Glu Arg              25 30 35 ggc ctg acg ctt tct ggt ggt caa cgc caa cgc atc gcc ctc gca cgg 259 Gly Leu Thr Leu Ser Gly Gly Gln Arg Gln Arg Ile Ala Leu Ala Arg          40 45 50 gct ttc ctg gcg cat ccc aaa gtg ttg gtg ctt gat gat gcc acc tct 307 Ala Phe Leu Ala His Pro Lys Val Leu Val Leu Asp Asp Ala Thr Ser      55 60 65 gcc att gat gcc tcc act gag gac cgc att ttc cag gcc ttg cgc gaa 355 Ala Ile Asp Ala Ser Thr Glu Asp Arg Ile Phe Gln Ala Leu Arg Glu  70 75 80 85 gaa ctg cac gat gtc acc att ttg atc atc gcg cac cgc cac tcc act 403 Glu Leu His Asp Val Thr Ile Leu Ile Ile Ala His Arg His Ser Thr                  90 95 100 ttg gag ctc ggc gat cgg gtt ggt ctg gtc gaa gat gga cgg gta aca 451 Leu Glu Leu Gly Asp Arg Val Gly Leu Val Glu Asp Gly Arg Val Thr             105 110 115 gca ctg gga ccg ttg agt gag atg cgt gat cac gct cgt ttc tcg cat 499 Ala Leu Gly Pro Leu Ser Glu Met Arg Asp His Ala Arg Phe Ser His         120 125 130 ctg atg gct ctt gat ttc cag gat tct cac gat ccg gaa ttc acc ctc 547 Leu Met Ala Leu Asp Phe Gln Asp Ser His Asp Pro Glu Phe Thr Leu     135 140 145 gac aac ggt tca cta ccc agc caa gag caa ttg tgg ccg gag gtc tcc 595 Asp Asn Gly Ser Leu Pro Ser Gln Glu Gln Leu Trp Pro Glu Val Ser 150 155 160 165 aca gaa aag cag tac aag att ctt gcg cct gcc cct ggt cga ggc cgt 643 Thr Glu Lys Gln Tyr Lys Ile Leu Ala Pro Ala Pro Gly Arg Gly Arg                 170 175 180 ggc atg tcc atg cca gca acc cct gag ctg ctc gcc cag att gag gcg 691 Gly Met Ser Met Pro Ala Thr Pro Glu Leu Leu Ala Gln Ile Glu Ala             185 190 195 ctg cca gca gca acg gaa gaa aca cga gtt gat gcc ggg agg cta cgc 739 Leu Pro Ala Ala Thr Glu Glu Thr Arg Val Asp Ala Gly Arg Leu Arg         200 205 210 acc agt acc tcc ggt ttc aaa ttg ctc agt tta ttc aag cag gtc cgt 787 Thr Ser Thr Ser Gly Phe Lys Leu Leu Ser Leu Phe Lys Gln Val Arg     215 220 225 tgg ctc gtc gtc gcg gtc atc gcg ttg ttg ctg gtg ggc gta gcc gcc 835 Trp Leu Val Val Ala Val Ile Ala Leu Leu Leu Val Gly Val Ala Ala 230 235 240 245 gat cta gca ttt cca aca ctg atg cgc gca gcc atc gac aac ggt gtg 883 Asp Leu Ala Phe Pro Thr Leu Met Arg Ala Ala Ile Asp Asn Gly Val                 250 255 260 caa gca caa agc acc tcc acg ttg tgg tgg atc gcc atc gca ggc agc 931 Gln Ala Gln Ser Thr Ser Thr Leu Trp Trp Ile Ala Ile Ala Gly Ser             265 270 275 gta gta gtc ctt ctg tcc tgg gcc gcc gcc gcg atc aac acg att atc 979 Val Val Val Leu Leu Ser Trp Ala Ala Ala Ala Ile Asn Thr Ile Ile         280 285 290 acg gca cgc acc ggt gaa cgg ctg ctt tac ggc ttg cgt ctg cgc tca 1027 Thr Ala Arg Thr Gly Glu Arg Leu Leu Tyr Gly Leu Arg Leu Arg Ser     295 300 305 ttt gtg cat cta ttg cgc ctg tcc atg agc tat ttc gaa cgc acc atg 1075 Phe Val His Leu Leu Arg Leu Ser Met Ser Tyr Phe Glu Arg Thr Met 310 315 320 325 tcc ggc cgc atc atg acg cgc atg acc acc gac atc gac aac ctc tcg 1123 Ser Gly Arg Ile Met Thr Arg Met Thr Thr Asp Ile Asp Asn Leu Ser                 330 335 340 tcc ttc ctc caa tca ggt ctg gcg caa aca gtt gtc tct gtg ggc acg 1171 Ser Phe Leu Gln Ser Gly Leu Ala Gln Thr Val Val Ser Val Gly Thr             345 350 355 ctc atc ggt gtg gtc acc atg ctc gcc atc acc gac gca caa cta gca 1219 Leu Ile Gly Val Val Thr Met Leu Ala Ile Thr Asp Ala Gln Leu Ala         360 365 370 ctc gtt gcg ctg tcc gtg gtg ccg atc atc atc gtg ctc act ctc att 1267 Leu Val Ala Leu Ser Val Val Pro Ile Ile Val Leu Thr Leu Ile     375 380 385 ttc cga cgc atc agc tcc agg ctg tac acc gct tca cgc gag caa gcc 1315 Phe Arg Arg Ile Ser Ser Arg Leu Tyr Thr Ala Ser Arg Glu Gln Ala 390 395 400 405 agc cag gtc aac gcg gta ttc cac gag tcc atc gcc ggt tta cgc acc 1363 Ser Gln Val Asn Ala Val Phe His Glu Ser Ile Ala Gly Leu Arg Thr                 410 415 420 gcg cag atg cac cgc atg gaa gac caa gtc ttt gac aat tat gcg ggc 1411 Ala Gln Met His Arg Met Glu Asp Gln Val Phe Asp Asn Tyr Ala Gly             425 430 435 gaa gca gag gaa ttc cga cgc ctg cgt gtg aaa tcc cag acg gcc atc 1459 Glu Ala Glu Glu Phe Arg Arg Leu Arg Val Lys Ser Gln Thr Ala Ile         440 445 450 gcc atc tac ttc ccc ggc ctt ggc gcg ctc tct gaa atc gcc cag gca 1507 Ala Ile Tyr Phe Pro Gly Leu Gly Ala Leu Ser Glu Ile Ala Gln Ala     455 460 465 ctc gtc ctc ggt ttc ggc gca ctg caa gta acg cgc ggc gac atc tcc 1555 Leu Val Leu Gly Phe Gly Ala Leu Gln Val Thr Arg Gly Asp Ile Ser 470 475 480 485 acc ggc gta ctc gtg gca ttc gtg ctg tac atg ggc ctg atg ttc ggc 1603 Thr Gly Val Leu Val Ala Phe Val Leu Tyr Met Gly Leu Met Phe Gly                 490 495 500 ccc atc caa caa cta agc caa atc ttc gac tcc tac caa caa gcc gcc 1651 Pro Ile Gln Gln Leu Ser Gln Ile Phe Asp Ser Tyr Gln Gln Ala Ala             505 510 515 gtc ggc ttc cgt cgc atc acc gaa ctg ctc gca acg cag ccc agc gtc 1699 Val Gly Phe Arg Arg Ile Thr Glu Leu Leu Ala Thr Gln Pro Ser Val         520 525 530 cag atc tgg gca cca aca ggc acg cta ggc agg ctg cca cgc agc ctt 1747 Gln Ile Trp Ala Pro Thr Gly Thr Leu Gly Arg Leu Pro Arg Ser Leu     535 540 545 tat tgc ttg acg acg tca cct tcg gct att cag acg atc cga tcc 1792 Tyr Cys Leu Thr Thr Ser Pro Ser Ala Ile Gln Thr Ile Arg Ser 550 555 560 tagacaacgt caccgtccag atc 1815 <210> 362 <211> 564 <212> PRT <213> Corynebacterium glutamicum <400> 362 Met Gly Leu Asp Val Ser Asp Glu Gln Ile Glu His Ala Ala Arg Leu   1 5 10 15 Ala Gln Ala His Asp Phe Ile Asp Arg Leu Pro Asn Lys Tyr Glu Glu              20 25 30 Val Ile Gly Glu Arg Gly Leu Thr Leu Ser Gly Gly Gln Arg Gln Arg          35 40 45 Ile Ala Leu Ala Arg Ala Phe Leu Ala His Pro Lys Val Leu Val Leu      50 55 60 Asp Asp Ala Thr Ser Ala Ile Asp Ala Ser Thr Glu Asp Arg Ile Phe  65 70 75 80 Gln Ala Leu Arg Glu Glu Leu His Asp Val Thr Ile Leu Ile Ila Ala                  85 90 95 His Arg His Ser Thr Leu Glu Leu Gly Asp Arg Val Gly Leu Val Glu             100 105 110 Asp Gly Arg Val Thr Ala Leu Gly Pro Leu Ser Glu Met Arg Asp His         115 120 125 Ala Arg Phe Ser His Leu Met Ala Leu Asp Phe Gln Asp Ser His Asp     130 135 140 Pro Glu Phe Thr Leu Asp Asn Gly Ser Leu Pro Ser Gln Glu Gln Leu 145 150 155 160 Trp Pro Glu Val Ser Thr Glu Lys Gln Tyr Lys Ile Leu Ala Pro Ala                 165 170 175 Pro Gly Arg Gly Arg Gly Met Ser Met Pro Ala Thr Pro Glu Leu Leu             180 185 190 Ala Gln Ile Glu Ala Leu Pro Ala Ala Thr Glu Glu Thr Arg Val Asp         195 200 205 Ala Gly Arg Leu Arg Thr Ser Thr Ser Gly Phe Lys Leu Leu Ser Leu     210 215 220 Phe Lys Gln Val Arg Trp Leu Val Val Ala Val Ile Ala Leu Leu Leu 225 230 235 240 Val Gly Val Ala Ala Asp Leu Ala Phe Pro Thr Leu Met Arg Ala Ala                 245 250 255 Ile Asp Asn Gly Val Gln Ala Gln Ser Thr Ser Thr Leu Trp Trp Ile             260 265 270 Ala Ile Ala Gly Ser Val Val Val Leu Leu Ser Trp Ala Ala Ala Ala         275 280 285 Ile Asn Thr Ile Ile Thr Ala Arg Thr Gly Glu Arg Leu Leu Tyr Gly     290 295 300 Leu Arg Leu Arg Ser Phe Val His Leu Leu Arg Leu Ser Met Ser Tyr 305 310 315 320 Phe Glu Arg Thr Met Ser Gly Arg Ile Met Thr Arg Met Thr Thr Asp                 325 330 335 Ile Asp Asn Leu Ser Ser Phe Leu Gln Ser Gly Leu Ala Gln Thr Val             340 345 350 Val Ser Val Gly Thr Leu Ile Gly Val Val Thr Met Leu Ala Ile Thr         355 360 365 Asp Ala Gln Leu Ala Leu Val Ala Leu Ser Val Val Pro Ile Ile     370 375 380 Val Leu Thr Leu Ile Phe Arg Arg Ile Ser Ser Arg Leu Tyr Thr Ala 385 390 395 400 Ser Arg Glu Gln Ala Ser Gln Val Asn Ala Val Phe His Glu Ser Ile                 405 410 415 Ala Gly Leu Arg Thr Ala Gln Met His Arg Met Glu Asp Gln Val Phe             420 425 430 Asp Asn Tyr Ala Gly Glu Ala Glu Glu Phe Arg Arg Leu Arg Val Lys         435 440 445 Ser Gln Thr Ala Ile Ala Ile Tyr Phe Pro Gly Leu Gly Ala Leu Ser     450 455 460 Glu Ile Ala Gln Ala Leu Val Leu Gly Phe Gly Ala Leu Gln Val Thr 465 470 475 480 Arg Gly Asp Ile Ser Thr Gly Val Leu Val Ala Phe Val Leu Tyr Met                 485 490 495 Gly Leu Met Phe Gly Pro Ile Gln Gln Leu Ser Gln Ile Phe Asp Ser             500 505 510 Tyr Gln Gln Ala Ala Val Gly Phe Arg Arg Ile Thr Glu Leu Leu Ala         515 520 525 Thr Gln Pro Ser Val Gln Ile Trp Ala Pro Thr Gly Thr Leu Gly Arg     530 535 540 Leu Pro Arg Ser Leu Tyr Cys Leu Thr Thr Ser Pro Pro Ala Ile Gln 545 550 555 560 Thr Ile Arg Ser <210> 363 <211> 1203 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (1180) <223> RXN00412 <400> 363 cttttgacga acaccacgtc gcgtacgctt cctcggggcg ttaaactatt tgtcttccag 60 cttttgtccc ccgacttttg tacgaatcga ggacaccgtc gtg tca cac acc gcg 115                                             Val Ser His Thr Ala                                               1 5 tcc aca ccg acg cca gag gaa tac tcc gcg cag caa ccc agc acc cag 163 Ser Thr Pro Thr Pro Glu Glu Tyr Ser Ala Gln Gln Pro Ser Thr Gln                  10 15 20 ggc act cgc gtt gag ttc cgc ggc ata acc aaa gtc ttt agc aac aat 211 Gly Thr Arg Val Glu Phe Arg Gly Ile Thr Lys Val Phe Ser Asn Asn              25 30 35 aaa tct gct aaa acc acc gcg ctt gat aat gtc act ctc acc gta gaa 259 Lys Ser Ala Lys Thr Thr Ala Leu Asp Asn Val Thr Leu Thr Val Glu          40 45 50 ccc ggt gag gta atc ggc atc atc ggt tac tct ggc gcc ggc aag tcc 307 Pro Gly Glu Val Ile Gly Ile Ile Gly Tyr Ser Gly Ala Gly Lys Ser      55 60 65 act ctt gtc cgc ctc atc aat ggc ctt gac tcc ccc acg agc ggt tcg 355 Thr Leu Val Arg Leu Ile Asn Gly Leu Asp Ser Pro Thr Ser Gly Ser  70 75 80 85 ttg ctg ctc aac ggc acc gac atc gtc gga atg ccc gag tct aag ctg 403 Leu Leu Leu Asn Gly Thr Asp Ile Val Gly Met Pro Glu Ser Lys Leu                  90 95 100 cgt aaa ctg cgc agt aat atc ggc atg att ttc cag cag ttc aac ctg 451 Arg Lys Leu Arg Ser Asn Ile Gly Met Ile Phe Gln Gln Phe Asn Leu             105 110 115 ttc cag tcg cgt act gcg gct gga aat gtg gag tac ccg ctg gaa gtt 499 Phe Gln Ser Arg Thr Ala Ala Gly Asn Val Glu Tyr Pro Leu Glu Val         120 125 130 gcc aag atg gac aag gca gct cgt aaa gct cgc gtg caa gaa atg ctc 547 Ala Lys Met Asp Lys Ala Ala Arg Lys Ala Arg Val Gln Glu Met Leu     135 140 145 gag ttc gtc ggc ctg ggc gac aaa ggc aaa aac tac ccc gag cag ctg 595 Glu Phe Val Gly Leu Gly Asp Lys Gly Lys Asn Tyr Pro Glu Gln Leu 150 155 160 165 tcg ggc ggc cag aag cag cgc gtc ggc att gcc cgt gca ctg gcc acc 643 Ser Gly Gly Gln Lys Gln Arg Val Gly Ile Ala Arg Ala Leu Ala Thr                 170 175 180 aat cca acg ctt ttg ctt gcc gac gaa gcc acc tcc gct ttg gac cca 691 Asn Pro Thr Leu Leu Leu Ala Asp Glu Ala Thr Ser Ala Leu Asp Pro             185 190 195 gaa acc acc cat gaa gtt ctg gag ctg ctg cgc aag gta aac cgc gaa 739 Glu Thr Thr His Glu Val Leu Glu Leu Leu Arg Lys Val Asn Arg Glu         200 205 210 ctg ggc atc acc atc gtt gtg atc acc cac gaa atg gaa gtt gtg cgt 787 Leu Gly Ile Thr Ile Val Val Ile Thr His Glu Met Glu Val Val Arg     215 220 225 tcc atc gca gac aag gtt gct gtg atg gaa tcc ggc aaa gtt gtg gaa 835 Ser Ile Ala Asp Lys Val Ala Val Met Glu Ser Gly Lys Val Val Glu 230 235 240 245 tac ggc agc gtc tac gag gtg ttc tcc aat cca caa aca cag gtt gct 883 Tyr Gly Ser Val Tyr Glu Val Phe Ser Asn Pro Gln Thr Gln Val Ala                 250 255 260 caa aag ttc gtg gcc acc gcg ctg cgt aac acc cca gac caa gtg gaa 931 Gln Lys Phe Val Ala Thr Ala Leu Arg Asn Thr Pro Asp Gln Val Glu             265 270 275 tcg gaa gat ctg ctt agc cat gag gga cgt ctg ttc acc att gat ctg 979 Ser Glu Asp Leu Leu Ser His Glu Gly Arg Leu Phe Thr Ile Asp Leu         280 285 290 act gaa acg tcc ggc ttc ttt gca gca acc gct cgt gct gcc gaa caa 1027 Thr Glu Thr Ser Gly Phe Phe Ala Ala Thr Ala Arg Ala Ala Glu Gln     295 300 305 ggt gct ttt gtc aac atc gtt cac ggt ggc gtg acc acc ttg caa cgc 1075 Gly Ala Phe Val Asn Ile Val His Gly Gly Val Thr Thr Leu Gln Arg 310 315 320 325 caa tca ttt ggc aaa atg act gtt cga ctc acc ggc aac acc gct gcg 1123 Gln Ser Phe Gly Lys Met Thr Val Arg Leu Thr Gly Asn Thr Ala Ala                 330 335 340 att gaa gag ttc tat caa acc ttg acc aag acc acg acc atc aag gag 1171 Ile Glu Glu Phe Tyr Gln Thr Leu Thr Lys Thr Thr Thr Ile Lys Glu             345 350 355 atc acc cga tgaacgagat gatcctcgca gct 1203 Ile Thr Arg         360 <210> 364 <211> 360 <212> PRT <213> Corynebacterium glutamicum <400> 364 Val Ser His Thr Ala Ser Thr Pro Thr Pro Glu Glu Tyr Ser Ala Gln   1 5 10 15 Gln Pro Ser Thr Gln Gly Thr Arg Val Glu Phe Arg Gly Ile Thr Lys              20 25 30 Val Phe Ser Asn Asn Lys Ser Ala Lys Thr Thr Ala Leu Asp Asn Val          35 40 45 Thr Leu Thr Val Glu Pro Gly Glu Val Ile Gly Ile Ile Gly Tyr Ser      50 55 60 Gly Ala Gly Lys Ser Thr Leu Val Arg Leu Ile Asn Gly Leu Asp Ser  65 70 75 80 Pro Thr Ser Gly Ser Leu Leu Leu Asn Gly Thr Asp Ile Val Gly Met                  85 90 95 Pro Glu Ser Lys Leu Arg Lys Leu Arg Ser Asn Ile Gly Met Ile Phe             100 105 110 Gln Gln Phe Asn Leu Phe Gln Ser Arg Thr Ala Ala Gly Asn Val Glu         115 120 125 Tyr Pro Leu Glu Val Ala Lys Met Asp Lys Ala Ala Arg Lys Ala Arg     130 135 140 Val Gln Glu Met Leu Glu Phe Val Gly Leu Gly Asp Lys Gly Lys Asn 145 150 155 160 Tyr Pro Glu Gln Leu Ser Gly Gly Gln Lys Gln Arg Val Gly Ile Ala                 165 170 175 Arg Ala Leu Ala Thr Asn Pro Thr Leu Leu Leu Ala Asp Glu Ala Thr             180 185 190 Ser Ala Leu Asp Pro Glu Thr Thr His Glu Val Leu Glu Leu Leu Arg         195 200 205 Lys Val Asn Arg Glu Leu Gly Ile Thr Ile Val Val Ile Thr His Glu     210 215 220 Met Glu Val Val Arg Ser Ile Ala Asp Lys Val Ala Val Met Glu Ser 225 230 235 240 Gly Lys Val Val Glu Tyr Gly Ser Val Tyr Glu Val Phe Ser Asn Pro                 245 250 255 Gln Thr Gln Val Ala Gln Lys Phe Val Ala Thr Ala Leu Arg Asn Thr             260 265 270 Pro Asp Gln Val Glu Ser Glu Asp Leu Leu Ser His Glu Gly Arg Leu         275 280 285 Phe Thr Ile Asp Leu Thr Glu Thr Ser Gly Phe Phe Ala Ala Thr Ala     290 295 300 Arg Ala Ala Glu Gln Gly Ala Phe Val Asn Ile Val His Gly Gly Val 305 310 315 320 Thr Thr Leu Gln Arg Gln Ser Phe Gly Lys Met Thr Val Arg Leu Thr                 325 330 335 Gly Asn Thr Ala Ala Ile Glu Glu Phe Tyr Gln Thr Leu Thr Lys Thr             340 345 350 Thr Thr Ile Lys Glu Ile Thr Arg         355 360 <210> 365 <211> 798 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (775) <223> RXN00411 <400> 365 catttggcaa aatgactgtt cgactcaccg gcaacaccgc tgcgattgaa gagttctatc 60 aaaccttgac caagaccacg accatcaagg agatcacccg atg aac gag atg atc 115                                             Met Asn Glu Met Ile                                               1 5 ctc gca gct gac tgg aac cgg cta gga ccc acc ttc caa aca gcc atc 163 Leu Ala Ala Asp Trp Asn Arg Leu Gly Pro Thr Phe Gln Thr Ala Ile                  10 15 20 att gac acc ctg ttg atg gtc atc atc acc atg gtg gtg gct ggc tta 211 Ile Asp Thr Leu Leu Met Val Ile Ile Thr Met Val Val Ala Gly Leu              25 30 35 ctg ggt ctt gtc gtc ggc ctg ctg ctt tac acc acc cgc gct ggt gga 259 Leu Gly Leu Val Val Gly Leu Leu Leu Tyr Thr Thr Arg Ala Gly Gly          40 45 50 atc ttg aag aac aag gtc atc tac acc att ttg aat gtg ctg gtg aac 307 Ile Leu Lys Asn Lys Val Ile Tyr Thr Ile Leu Asn Val Leu Val Asn      55 60 65 ttt gtt cga ccc atc cca ttc att att ttg atc gcc gcc atc aag cca 355 Phe Val Arg Pro Ile Pro Phe Ile Ile Leu Ile Ala Ala Ile Lys Pro  70 75 80 85 cta acg gtc gcc gtc atg ggc acc tcc atc ggc cga gat gcc ggc atc 403 Leu Thr Val Ala Val Met Gly Thr Ser Ile Gly Arg Asp Ala Gly Ile                  90 95 100 ttc gtc atg gtt gtc gca gcg att ttc tct gtg gct cga atc gtg gag 451 Phe Val Met Val Val Ala Ala Ile Phe Ser Val Ala Arg Ile Val Glu             105 110 115 caa aac ttg gtc tcc att gat cct ggt gtc atc gag gca gct cgc tcc 499 Gln Asn Leu Val Ser Ile Asp Pro Gly Val Ile Glu Ala Ala Arg Ser         120 125 130 atg ggt gcg tcc ccg atg cgc atc atc gcc acc gtg atc att cca gaa 547 Met Gly Ala Ser Pro Met Arg Ile Ile Ala Thr Val Ile Ile Pro Glu     135 140 145 gca ctt gga cca ttg gtt ctg ggt tac acc ttc ctg ttc atc gcg atc 595 Ala Leu Gly Pro Leu Val Leu Gly Tyr Thr Phe Leu Phe Ile Ala Ile 150 155 160 165 gtc gat atg tcc gca atg gtc ggc tac atc ggt ggc ggt ggt ctt ggt 643 Val Asp Met Ser Ala Met Val Gly Tyr Ile Gly Gly Gly Gly Leu Gly                 170 175 180 gac ttc gcc att gtt tac ggc tac cgc gcc ttc gac aac gaa gtt atg 691 Asp Phe Ala Ile Val Tyr Gly Tyr Arg Ala Phe Asp Asn Glu Val Met             185 190 195 tac gtt gcc gtc ctg gtt atc gtc atc atc gtg cag gca gcc cag ctt 739 Tyr Val Ala Val Leu Val Ile Val Ile Ile Val Gln Ala Ala Gln Leu         200 205 210 ctg ggc aat tgg ctg tcc aag aag atc atg cgc cgc taaacctctt 785 Leu Gly Asn Trp Leu Ser Lys Lys Ile Met Arg Arg     215 220 225 gcatagaaaa acc 798 <210> 366 <211> 225 <212> PRT <213> Corynebacterium glutamicum <400> 366 Met Asn Glu Met Ile Leu Ala Ala Asp Trp Asn Arg Leu Gly Pro Thr   1 5 10 15 Phe Gln Thr Ala Ile Ile Asp Thr Leu Leu Met Val Ile Ile Thr Met              20 25 30 Val Val Ala Gly Leu Leu Gly Leu Val Val Gly Leu Leu Leu Tyr Thr          35 40 45 Thr Arg Ala Gly Gly Ile Leu Lys Asn Lys Val Ile Tyr Thr Ile Leu      50 55 60 Asn Val Leu Val Asn Phe Val Arg Pro Ile Pro Phe Ile Ile Leu Ile  65 70 75 80 Ala Ala Ile Lys Pro Leu Thr Val Ala Val Met Gly Thr Ser Ile Gly                  85 90 95 Arg Asp Ala Gly Ile Phe Val Met Val Val Ala Ala Ile Phe Ser Val             100 105 110 Ala Arg Ile Val Glu Gln Asn Leu Val Ser Ile Asp Pro Gly Val Ile         115 120 125 Glu Ala Ala Arg Ser Met Gly Ala Ser Pro Met Arg Ile Ile Ala Thr     130 135 140 Val Ile Ile Pro Glu Ala Leu Gly Pro Leu Val Leu Gly Tyr Thr Phe 145 150 155 160 Leu Phe Ile Ala Ile Val Asp Met Ser Ala Met Val Gly Tyr Ile Gly                 165 170 175 Gly Gly Gly Leu Gly Asp Phe Ala Ile Val Tyr Gly Tyr Arg Ala Phe             180 185 190 Asp Asn Glu Val Met Tyr Val Ala Val Leu Val Ile Val Ile Ile Val         195 200 205 Gln Ala Ala Gln Leu Leu Gly Asn Trp Leu Ser Lys Lys Ile Met Arg     210 215 220 Arg 225 <210> 367 <211> 852 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (829) <223> RXN02614 <400> 367 tcattgtata cgccaccctc ggtctgctgt ctgaagcgct gatcagagct tgggaacgtc 60 acaccttccg ctaccgaaac gcataagaaa gttgctcgcc atg act gcc aca ttg 115                                             Met Thr Ala Thr Leu                                               1 5 tca ctc aaa ccc gca gcc act gtc cgt gga ttg cgc aaa tca tac gga 163 Ser Leu Lys Pro Ala Ala Thr Val Arg Gly Leu Arg Lys Ser Tyr Gly                  10 15 20 act aaa gaa gtc ctc caa gga atc gac ctc acc atc aac tgc ggc gaa 211 Thr Lys Glu Val Leu Gln Gly Ile Asp Leu Thr Ile Asn Cys Gly Glu              25 30 35 gta acc gcg ctg atc gga cgc tca ggt tca gga aaa tcc acc atc ctg 259 Val Thr Ala Leu Ile Gly Arg Ser Gly Ser Gly Lys Ser Thr Ile Leu          40 45 50 cgc gtg ttg gcg ggc cta tct aaa gag cat tcc ggc tct gta gaa att 307 Arg Val Leu Ala Gly Leu Ser Lys Glu His Ser Gly Ser Val Glu Ile      55 60 65 tcc gga aac ccg gcc gtt gcc ttc caa gag cct cgc ctg ttg ccg tgg 355 Ser Gly Asn Pro Ala Val Ala Phe Gln Glu Pro Arg Leu Leu Pro Trp  70 75 80 85 aaa acg gtg ctc gat aat gtg acc ttt ggc ctc aac cgc act gat att 403 Lys Thr Val Leu Asp Asn Val Thr Phe Gly Leu Asn Arg Thr Asp Ile                  90 95 100 tcc tgg tca gaa gca caa gaa cgc gcc tcg gca ctg ctt gca gaa gtc 451 Ser Trp Ser Glu Ala Gln Glu Arg Ala Ser Ala Leu Leu Ala Glu Val             105 110 115 aaa ctt ccc gac tcc gac gcc gcc tgg ccc ctc acg ctc tcc ggc ggc 499 Lys Leu Pro Asp Ser Asp Ala Ala Trp Pro Leu Thr Leu Ser Gly Gly         120 125 130 caa gcc cag cgc gtc tcc ctt gcg cga gcg ctc atc tcc gag cca gag 547 Gln Ala Gln Arg Val Ser Leu Ala Arg Ala Leu Ile Ser Glu Pro Glu     135 140 145 ctt ttg ctt ctc gac gaa ccc ttc ggc gcc ctc gat gct ctg aca aga 595 Leu Leu Leu Leu Asp Glu Pro Phe Gly Ala Leu Asp Ala Leu Thr Arg 150 155 160 165 ctg aca gcc caa gac ctg ctg ctc aaa acc gtg aac acc cga aac ttg 643 Leu Thr Ala Gln Asp Leu Leu Leu Lys Thr Val Asn Thr Arg Asn Leu                 170 175 180 gga gtt ctg ctg gtc acc cat gat gtt tcc gag gcc atc gcc ctg gcc 691 Gly Val Leu Leu Val Thr His Asp Val Ser Glu Ala Ile Ala Leu Ala             185 190 195 gac cac gtc ctt ctt ctt gac gac ggc gcc atc aca cac agt ttg act 739 Asp His Val Leu Leu Leu Asp Asp Gly Ala Ile Thr His Ser Leu Thr         200 205 210 gta gat atc ccc ggc gat cgc cgc acc cac ccc tcc ttt gcc tcc tac 787 Val Asp Ile Pro Gly Asp Arg Arg Thr His Pro Ser Phe Ala Ser Tyr     215 220 225 acc gct caa ctc ctt gag tgg ctc gaa atc acc aca cct gcc 829 Thr Ala Gln Leu Leu Glu Trp Leu Glu Ile Thr Thr Pro Ala 230 235 240 tagaaagaaa tcatgaaatt taa 852 <210> 368 <211> 243 <212> PRT <213> Corynebacterium glutamicum <400> 368 Met Thr Ala Thr Leu Ser Leu Lys Pro Ala Ala Thr Val Arg Gly Leu   1 5 10 15 Arg Lys Ser Tyr Gly Thr Lys Glu Val Leu Gln Gly Ile Asp Leu Thr              20 25 30 Ile Asn Cys Gly Glu Val Thr Ala Leu Ile Gly Arg Ser Gly Ser Gly          35 40 45 Lys Ser Thr Ile Leu Arg Val Leu Ala Gly Leu Ser Lys Glu His Ser      50 55 60 Gly Ser Val Glu Ile Ser Gly Asn Pro Ala Val Ala Phe Gln Glu Pro  65 70 75 80 Arg Leu Leu Pro Trp Lys Thr Val Leu Asp Asn Val Thr Phe Gly Leu                  85 90 95 Asn Arg Thr Asp Ile Ser Trp Ser Glu Ala Gln Glu Arg Ala Ser Ala             100 105 110 Leu Leu Ala Glu Val Lys Leu Pro Asp Ser Asp Ala Ala Trp Pro Leu         115 120 125 Thr Leu Ser Gly Gly Gln Ala Gln Arg Val Ser Leu Ala Arg Ala Leu     130 135 140 Ile Ser Glu Pro Glu Leu Leu Leu Leu Asp Glu Pro Phe Gly Ala Leu 145 150 155 160 Asp Ala Leu Thr Arg Leu Thr Ala Gln Asp Leu Leu Leu Lys Thr Val                 165 170 175 Asn Thr Arg Asn Leu Gly Val Leu Leu Val Thr His Asp Val Ser Glu             180 185 190 Ala Ile Ala Leu Ala Asp His Val Leu Leu Leu Asp Asp Gly Ala Ile         195 200 205 Thr His Ser Leu Thr Val Asp Ile Pro Gly Asp Arg Arg Thr His Pro     210 215 220 Ser Phe Ala Ser Tyr Thr Ala Gln Leu Leu Glu Trp Leu Glu Ile Thr 225 230 235 240 Thr Pro Ala <210> 369 <211> 1080 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1057) <223> RXN02613 <400> 369 agatatcccc ggcgatcgcc gcacccaccc ctcctttgcc tcctacaccg ctcaactcct 60 tgagtggctc gaaatcacca cacctgccta gaaagaaatc atg aaa ttt aag aaa 115                                             Met Lys Phe Lys Lys                                               1 5 atc gcc ctc gtt ctc gcc ttc ggt cta ggc ctt gca tcc tgc tca tca 163 Ile Ala Leu Val Leu Ala Phe Gly Leu Gly Leu Ala Ser Cys Ser Ser                  10 15 20 gct tct ggc gat ccc gcc acc aac gcc gat gga tcc atc gat ctg agc 211 Ala Ser Gly Asp Pro Ala Thr Asn Ala Asp Gly Ser Ile Asp Leu Ser              25 30 35 aaa gta acc ctt aac atc ggt gat caa atc gcc gga aca gaa caa gtg 259 Lys Val Thr Leu Asn Ile Gly Asp Gln Ile Ala Gly Thr Glu Gln Val          40 45 50 ctc caa gct tca ggg gag cta gat gat gtc cct tat aaa atc gaa tgg 307 Leu Gln Ala Ser Gly Glu Leu Asp Asp Val Pro Tyr Lys Ile Glu Trp      55 60 65 tca tca ttt acc tct gga cca ccc caa atc gaa gca tta aac gca ggt 355 Ser Ser Phe Thr Ser Gly Pro Pro Gln Ile Glu Ala Leu Asn Ala Gly  70 75 80 85 caa att gat ttc gcg atc acc gga aac acc cca ccg atc atc ggc ggc 403 Gln Ile Asp Phe Ala Ile Thr Gly Asn Thr Pro Pro Ile Ile Gly Gly                  90 95 100 ccc acc aac acc aaa gtg gtc tcc gcc tac aac aac gat gct tta ggt 451 Pro Thr Asn Thr Lys Val Val Ser Ala Tyr Asn Asn Asp Ala Leu Gly             105 110 115 gat gtc atc ttg gtc gcc ccg gat tct tca ata acc tcg gtg gct gac 499 Asp Val Ile Leu Val Ala Pro Asp Ser Ser Ile Thr Ser Val Ala Asp         120 125 130 ctt gct gga aag aaa gtg gct gtc gcc cgc gga tcc agc gcc cac gga 547 Leu Ala Gly Lys Lys Val Ala Val Ala Arg Gly Ser Ser Ala His Gly     135 140 145 cac ctc atc caa caa cta gaa aaa gca ggc gtg agc gtt gac gac gta 595 His Leu Ile Gln Gln Leu Glu Lys Ala Gly Val Ser Val Asp Asp Val 150 155 160 165 gaa atc aac ctc ctc caa ccc tcc gac gcc aaa gcc gct ttc caa aac 643 Glu Ile Asn Leu Leu Gln Pro Ser Asp Ala Lys Ala Ala Phe Gln Asn                 170 175 180 ggc cag gta gat gcg tgg gca gtg tgg gat ccc tac agc tca cag gcg 691 Gly Gln Val Asp Ala Trp Ala Val Trp Asp Pro Tyr Ser Ser Gln Ala             185 190 195 gaa ctg gaa gga gct caa gtt ttg gtc agg gga gcg gga ctg gtc agt 739 Glu Leu Glu Gly Ala Gln Val Leu Val Arg Gly Ala Gly Leu Val Ser         200 205 210 ggg cat gga ttt ggt gtc gca agt gat gaa gcg ctc gat gac ccc gca 787 Gly His Gly Phe Gly Val Ala Ser Asp Glu Ala Leu Asp Asp Pro Ala     215 220 225 aag gaa gcc gcc ttg gca gat ttc ctc gat cgc gtg gcc gac tct tat 835 Lys Glu Ala Ala Leu Ala Asp Phe Leu Asp Arg Val Ala Asp Ser Tyr 230 235 240 245 gaa tgg gct gaa gac aac acc gat gaa tgg gcg acg att ttc agc caa 883 Glu Trp Ala Glu Asp Asn Thr Asp Glu Trp Ala Thr Ile Phe Ser Gln                 250 255 260 gaa tcc ggc ttt gat ccg gag gcc tct caa ctg aac acc cgc agc ctg 931 Glu Ser Gly Phe Asp Pro Glu Ala Ser Gln Leu Asn Thr Arg Ser Leu             265 270 275 cgc cat cag gtg ccg ctc gac gag tcc gtc aac acc tat cag aac gcg 979 Arg His Gln Val Pro Leu Asp Glu Ser Val Asn Thr Tyr Gln Asn Ala         280 285 290 ctt atc gac gct ttc gtc tcc gcg ggt ctc gtt gag gac ttt aat ttc 1027 Leu Ile Asp Ala Phe Val Ser Ala Gly Leu Val Glu Asp Phe Asn Phe     295 300 305 gag gac acc gta gac acc cga ttt gag ggc taagtatgtc tgagtatggc 1077 Glu Asp Thr Val Asp Thr Arg Phe Glu Gly 310 315 aaa 1080 <210> 370 <211> 319 <212> PRT <213> Corynebacterium glutamicum <400> 370 Met Lys Phe Lys Lys Ile Ala Leu Val Leu Ala Phe Gly Leu Gly Leu   1 5 10 15 Ala Ser Cys Ser Ser Ala Ser Gly Asp Pro Ala Thr Asn Ala Asp Gly              20 25 30 Ser Ile Asp Leu Ser Lys Val Thr Leu Asn Ile Gly Asp Gln Ile Ala          35 40 45 Gly Thr Glu Gln Val Leu Gln Ala Ser Gly Glu Leu Asp Asp Val Pro      50 55 60 Tyr Lys Ile Glu Trp Ser Ser Phe Thr Ser Gly Pro Pro Gln Ile Glu  65 70 75 80 Ala Leu Asn Ala Gly Gln Ile Asp Phe Ala Ile Thr Gly Asn Thr Pro                  85 90 95 Pro Ile Ile Gly Gly Pro Thr Asn Thr Lys Val Val Ser Ala Tyr Asn             100 105 110 Asn Asp Ala Leu Gly Asp Val Ile Leu Val Ala Pro Asp Ser Ser Ile         115 120 125 Thr Ser Val Ala Asp Leu Ala Gly Lys Lys Val Ala Val Ala Arg Gly     130 135 140 Ser Ser Ala His Gly His Leu Ile Gln Gln Leu Glu Lys Ala Gly Val 145 150 155 160 Ser Val Asp Asp Val Glu Ile Asn Leu Leu Gln Pro Ser Asp Ala Lys                 165 170 175 Ala Ala Phe Gln Asn Gly Gln Val Asp Ala Trp Ala Val Trp Asp Pro             180 185 190 Tyr Ser Ser Gln Ala Glu Leu Glu Gly Ala Gln Val Leu Val Arg Gly         195 200 205 Ala Gly Leu Val Ser Gly His Gly Phe Gly Val Ala Ser Asp Glu Ala     210 215 220 Leu Asp Asp Pro Ala Lys Glu Ala Ala Leu Ala Asp Phe Leu Asp Arg 225 230 235 240 Val Ala Asp Ser Tyr Glu Trp Ala Glu Asp Asn Thr Asp Glu Trp Ala                 245 250 255 Thr Ile Phe Ser Gln Glu Ser Gly Phe Asp Pro Glu Ala Ser Gln Leu             260 265 270 Asn Thr Arg Ser Leu Arg His Gln Val Pro Leu Asp Glu Ser Val Asn         275 280 285 Thr Tyr Gln Asn Ala Leu Ile Asp Ala Phe Val Ser Ala Gly Leu Val     290 295 300 Glu Asp Phe Asn Phe Glu Asp Thr Val Asp Thr Arg Phe Glu Gly 305 310 315 <210> 371 <211> 1698 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (1675) <223> RXN00368 <400> 371 ttcttccaaa acgcaatgaa ctagttttcc tatgcagtta tctccttcaa atacgtcgac 60 gcagcgcttt cacatctctg cgttgacgtc tttgtctttc atg cgt ctg ggt gtg 115                                             Met Arg Leu Gly Val                                               1 5 tgg ctg att gtc gcg ggg ttg ttt atc act ccg ttg gcg ctg gtg gtg 163 Trp Leu Ile Val Ala Gly Leu Phe Ile Thr Pro Leu Ala Leu Val Val                  10 15 20 ggc ttg gcg ttg gga ggc aat cag ttt cct gct ctg tgg gat tcc gga 211 Gly Leu Ala Leu Gly Gly Asn Gln Phe Pro Ala Leu Trp Asp Ser Gly              25 30 35 ttg ggc aaa gcc cta tgg aat tcc gcc tat aca aca gtg ctt tct gcg 259 Leu Gly Lys Ala Leu Trp Asn Ser Ala Tyr Thr Thr Val Leu Ser Ala          40 45 50 gtg ggc gcg acc att atc ggc acg atc atg gct ctc acg ctg gac cga 307 Val Gly Ala Thr Ile Ile Gly Thr Ile Met Ala Leu Thr Leu Asp Arg      55 60 65 act gat gtt ttc ggg cgc acc gcg ttg cgg tta ttt ttg tta tcc ccg 355 Thr Asp Val Phe Gly Arg Thr Ala Leu Arg Leu Phe Leu Leu Ser Pro  70 75 80 85 ctg ttg atc cct ccg ttt att ggg gct att gcg tgg ttg cag ctg ttc 403 Leu Leu Ile Pro Pro Phe Ile Gly Ala Ile Ala Trp Leu Gln Leu Phe                  90 95 100 ggg aag aac cag ggc atc aac cgg ttt ttc ggc acg gaa gtg tgg gat 451 Gly Lys Asn Gln Gly Ile Asn Arg Phe Phe Gly Thr Glu Val Trp Asp             105 110 115 att tac ggc gct gat ggt gtg aca ttt ttg ttg att gtg cac tcc tat 499 Ile Tyr Gly Ala Asp Gly Val Thr Phe Leu Leu Ile Val His Ser Tyr         120 125 130 ccc act gtg tac atc att gtt tcg gca gct ctg agg caa ctt cct agt 547 Pro Thr Val Tyr Ile Ile Val Ser Ala Ala Leu Arg Gln Leu Pro Ser     135 140 145 gat ttg gag caa gct gca cgg atc gcg ggg gcg gat act ttt acg gtg 595 Asp Leu Glu Gln Ala Ala Arg Ile Ala Gly Ala Asp Thr Phe Thr Val 150 155 160 165 ttg cgc acc atc aca ctc cca ctg ctc aaa cct gca ttg ttg tcg gcg 643 Leu Arg Thr Ile Thr Leu Pro Leu Leu Lys Pro Ala Leu Leu Ser Ala                 170 175 180 ttt act ctt acc aca gtg gcg aac ctc gcc gac ttt ggc att cca gct 691 Phe Thr Leu Thr Thr Val Ala Asn Leu Ala Asp Phe Gly Ile Pro Ala             185 190 195 ctg ttg gga tcg cca gcg cgt ttt gaa acc tta gcc acc atg att tat 739 Leu Leu Gly Ser Pro Ala Arg Phe Glu Thr Leu Ala Thr Met Ile Tyr         200 205 210 cgc ttc atg gaa tcc ggc acc gtg agc aat cca ttg cag gtg gta tcc 787 Arg Phe Met Glu Ser Gly Thr Val Ser Asn Pro Leu Gln Val Val Ser     215 220 225 acc att ggc atc gtg ttg ttg ttc ctg gga atc gca gca gta acc gcg 835 Thr Ile Gly Ile Val Leu Leu Phe Leu Gly Ile Ala Ala Val Thr Ala 230 235 240 245 gat tat ctg gtg tct ttg tac gcg gca tca aag ttg caa gac gca gga 883 Asp Tyr Leu Val Ser Leu Tyr Ala Ala Ser Lys Leu Gln Asp Ala Gly                 250 255 260 aca ccg cat cgc ttt act ctc aac aaa tca cga atc cca gtc agc gtg 931 Thr Pro His Arg Phe Thr Leu Asn Lys Ser Arg Ile Pro Val Ser Val             265 270 275 atc acg tgg atc atc gcg ttg atc atc acc gcc gcc ccg ctg ctg ggt 979 Ile Thr Trp Ile Ile Ala Leu Ile Ile Thr Ala Ala Pro Leu Leu Gly         280 285 290 ctg gca tac aga gca tta ctg cct gcc cca ggt gtg ccg ttc aac cta 1027 Leu Ala Tyr Arg Ala Leu Leu Pro Ala Pro Gly Val Pro Phe Asn Leu     295 300 305 gac aac atc acg ctc aac aac ttt gaa gca gca ctg agc aat cca cga 1075 Asp Asn Ile Thr Leu Asn Asn Phe Glu Ala Ala Leu Ser Asn Pro Arg 310 315 320 325 gta atc gaa gga ttc agc aac tcc ctc atg tta tcc ctg ggt gca gcc 1123 Val Ile Glu Gly Phe Ser Asn Ser Leu Met Leu Ser Leu Gly Ala Ala                 330 335 340 cta atc tgt ggg gtg ctg gga tgg ctg atc gga gtg ctc atc acc cga 1171 Leu Ile Cys Gly Val Leu Gly Trp Leu Ile Gly Val Leu Ile Thr Arg             345 350 355 acc cag cat ttc gcc aac gta ccg ttg aca ctc act gtg ctg ctt ccc 1219 Thr Gln His Phe Ala Asn Val Pro Leu Thr Leu Thr Val Leu Leu Pro         360 365 370 acc gca ctg ccg ggc atg atc atc ggc gtc ggc tgg ctc att ttg ggc 1267 Thr Ala Leu Pro Gly Met Ile Gle Val Gly Trp Leu Ile Leu Gly     375 380 385 aga tac acc gga att tac aac aca cct tgg gtg att ttg ggt gca tat 1315 Arg Tyr Thr Gly Ile Tyr Asn Thr Pro Trp Val Ile Leu Gly Ala Tyr 390 395 400 405 gtg tgt gct ttt acc gcg ctg gtt gtc caa gct gta cgc gga cca ctc 1363 Val Cys Ala Phe Thr Ala Leu Val Val Gln Ala Val Arg Gly Pro Leu                 410 415 420 agt caa gca ccc gaa gca atc gaa gaa gcc gca cga atc agc ggc gca 1411 Ser Gln Ala Pro Glu Ala Ile Glu Glu Ala Ala Arg Ile Ser Gly Ala             425 430 435 ggc aga tta cga tcc atc atg gac acc gga gcg atg gca att ccc 1459 Gly Arg Leu Arg Ser Ile Met Asp Thr Thr Gly Ala Met Ala Ile Pro         440 445 450 gca gct ttc gcc ggc gca gtg ctg gtt gcg gta act gcg gtt cga gag 1507 Ala Ala Phe Ala Gly Ala Val Leu Val Ala Val Thr Ala Val Arg Glu     455 460 465 tta acc gtg tcc att ttg ctc atc gcg ccg ggc acc acc acc ctg ggt 1555 Leu Thr Val Ser Ile Leu Leu Ile Ala Pro Gly Thr Thr Thr Leu Gly 470 475 480 485 gtg cag gtg ttc aat ttg cag cag gcg gga aat tac aat cag gca tcg 1603 Val Gln Val Phe Asn Leu Gln Gln Ala Gly Asn Tyr Asn Gln Ala Ser                 490 495 500 gcg ttg tcg ttg atg ttt gcg att atc ggt atc gtg gcg ctc gcg ttg 1651 Ala Leu Ser Leu Met Phe Ala Ile Ile Gly Ile Val Ala Leu Ala Leu             505 510 515 acg gtg cgc agc cag aag gag ttt taggtgtcat cgatcaaatt gcg 1698 Thr Val Arg Ser Gln Lys Glu Phe         520 525 <210> 372 <211> 525 <212> PRT <213> Corynebacterium glutamicum <400> 372 Met Arg Leu Gly Val Trp Leu Ile Val Ala Gly Leu Phe Ile Thr Pro   1 5 10 15 Leu Ala Leu Val Val Gly Leu Ala Leu Gly Gly Asn Gln Phe Pro Ala              20 25 30 Leu Trp Asp Ser Gly Leu Gly Lys Ala Leu Trp Asn Ser Ala Tyr Thr          35 40 45 Thr Val Leu Ser Ala Val Gly Ala Thr Ile Ile Gly Thr Ile Met Ala      50 55 60 Leu Thr Leu Asp Arg Thr Asp Val Phe Gly Arg Thr Ala Leu Arg Leu  65 70 75 80 Phe Leu Leu Ser Pro Leu Leu Ile Pro Pro Phe Ile Gly Ala Ile Ala                  85 90 95 Trp Leu Gln Leu Phe Gly Lys Asn Gln Gly Ile Asn Arg Phe Phe Gly             100 105 110 Thr Glu Val Trp Asp Ile Tyr Gly Ala Asp Gly Val Thr Phe Leu Leu         115 120 125 Ile Val His Ser Tyr Pro Thr Val Tyr Ile Ile Val Ser Ala Ala Leu     130 135 140 Arg Gln Leu Pro Ser Asp Leu Glu Gln Ala Ala Arg Ile Ala Gly Ala 145 150 155 160 Asp Thr Phe Thr Val Leu Arg Thr Ile Thr Leu Pro Leu Leu Lys Pro                 165 170 175 Ala Leu Leu Ser Ala Phe Thr Leu Thr Thr Val Ala Asn Leu Ala Asp             180 185 190 Phe Gly Ile Pro Ala Leu Leu Gly Ser Pro Ala Arg Phe Glu Thr Leu         195 200 205 Ala Thr Met Ile Tyr Arg Phe Met Glu Ser Gly Thr Val Ser Asn Pro     210 215 220 Leu Gln Val Val Ser Thr Ile Gly Ile Val Leu Leu Phe Leu Gly Ile 225 230 235 240 Ala Ala Val Thr Ala Asp Tyr Leu Val Ser Leu Tyr Ala Ala Ser Lys                 245 250 255 Leu Gln Asp Ala Gly Thr Pro His Arg Phe Thr Leu Asn Lys Ser Arg             260 265 270 Ile Pro Val Ser Val Ile Thr Trp Ile Ile Ala Leu Ile Ile Thr Ala         275 280 285 Ala Pro Leu Leu Gly Leu Ala Tyr Arg Ala Leu Leu Pro Ala Pro Gly     290 295 300 Val Pro Phe Asn Leu Asp Asn Ile Thr Leu Asn Asn Phe Glu Ala Ala 305 310 315 320 Leu Ser Asn Pro Arg Val Ile Glu Gly Phe Ser Asn Ser Leu Met Leu                 325 330 335 Ser Leu Gly Ala Ala Leu Ile Cys Gly Val Leu Gly Trp Leu Ile Gly             340 345 350 Val Leu Ile Thr Arg Thr Gln His Phe Ala Asn Val Pro Leu Thr Leu         355 360 365 Thr Val Leu Leu Pro Thr Ala Leu Pro Gly Met Ile Ile Gly Val Gly     370 375 380 Trp Leu Ile Leu Gly Arg Tyr Thr Gly Ile Tyr Asn Thr Pro Trp Val 385 390 395 400 Ile Leu Gly Ala Tyr Val Cys Ala Phe Thr Ala Leu Val Val Gln Ala                 405 410 415 Val Arg Gly Pro Leu Ser Gln Ala Pro Glu Ala Ile Glu Glu Ala Ala             420 425 430 Arg Ile Ser Gly Ala Gly Arg Leu Arg Ser Ile Met Asp Thr Thr Gly         435 440 445 Ala Met Ala Ile Pro Ala Ala Phe Ala Gly Ala Val Leu Val Ala Val     450 455 460 Thr Ala Val Arg Glu Leu Thr Val Ser Ile Leu Leu Ile Ala Pro Gly 465 470 475 480 Thr Thr Thr Leu Gly Val Gln Val Phe Asn Leu Gln Gln Ala Gly Asn                 485 490 495 Tyr Asn Gln Ala Ser Ala Leu Ser Leu Met Phe Ala Ile Ile Gly Ile             500 505 510 Val Ala Leu Ala Leu Thr Val Arg Ser Gln Lys Glu Phe         515 520 525 <210> 373 <211> 602 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (579) <223> FRXA00368 <400> 373 tcc ctc atg tta tcc ctg ggt gca gcc cta atc tgt ggg gtg ctg gga 48 Ser Leu Met Leu Ser Leu Gly Ala Ala Leu Ile Cys Gly Val Leu Gly   1 5 10 15 tgg ctg atc gga gtg ctc atc acc cga acc cag cat ttc gcc aac gta 96 Trp Leu Ile Gly Val Leu Ile Thr Arg Thr Gln His Phe Ala Asn Val              20 25 30 ccg ttg aca ctc act gtg ctg ctt ccc acc gca ctg ccg ggc atg atc 144 Pro Leu Thr Leu Thr Val Leu Leu Pro Thr Ala Leu Pro Gly Met Ile          35 40 45 atc ggc gtc ggc tgg ctc att ttg ggc aga tac acc gga att tac aac 192 Ile Gly Val Gly Trp Leu Ile Leu Gly Arg Tyr Thr Gly Ile Tyr Asn      50 55 60 aca cct tgg gtg att ttg ggt gca tat gtg tgt gct ttt acc gcg ctg 240 Thr Pro Trp Val Ile Leu Gly Ala Tyr Val Cys Ala Phe Thr Ala Leu  65 70 75 80 gtt gtc caa gct gta cgc gga cca ctc agt caa gca ccc gaa gca atc 288 Val Val Gln Ala Val Arg Gly Pro Leu Ser Gln Ala Pro Glu Ala Ile                  85 90 95 gaa gaa gcc gca cga atc agc ggc gca ggc aga tta cga tcc atc atg 336 Glu Glu Ala Ala Arg Ile Ser Gly Ala Gly Arg Leu Arg Ser Ile Met             100 105 110 gac acc acc gga gcg atg gca att ccc gca gct ttc gcc ggc gca gtg 384 Asp Thr Thr Gly Ala Met Ala Ile Pro Ala Ala Phe Ala Gly Ala Val         115 120 125 ctg gtt gcg gta act gcg gtt cga gag tta acc gtg tcc att ttg ctc 432 Leu Val Ala Val Thr Ala Val Arg Glu Leu Thr Val Ser Ile Leu Leu     130 135 140 atc gcg ccg ggc acc acc acc ctg ggt gtg cag gtg ttc aat ttg cag 480 Ile Ala Pro Gly Thr Thr Thr Leu Gly Val Gln Val Phe Asn Leu Gln 145 150 155 160 cag gcg gga aat tac aat cag gca tcg gcg ttg tcg ttg atg ttt gcg 528 Gln Ala Gly Asn Tyr Asn Gln Ala Ser Ala Leu Ser Leu Met Phe Ala                 165 170 175 att atc ggt atc gtg gcg ctc gcg ttg acg gtg cgc agc cag aag gag 576 Ile Ile Gly Ile Val Ala Leu Ala Leu Thr Val Arg Ser Gln Lys Glu             180 185 190 ttt taggtgtcat cgatcaaatt gcg 602 Phe <210> 374 <211> 193 <212> PRT <213> Corynebacterium glutamicum <400> 374 Ser Leu Met Leu Ser Leu Gly Ala Ala Leu Ile Cys Gly Val Leu Gly   1 5 10 15 Trp Leu Ile Gly Val Leu Ile Thr Arg Thr Gln His Phe Ala Asn Val              20 25 30 Pro Leu Thr Leu Thr Val Leu Leu Pro Thr Ala Leu Pro Gly Met Ile          35 40 45 Ile Gly Val Gly Trp Leu Ile Leu Gly Arg Tyr Thr Gly Ile Tyr Asn      50 55 60 Thr Pro Trp Val Ile Leu Gly Ala Tyr Val Cys Ala Phe Thr Ala Leu  65 70 75 80 Val Val Gln Ala Val Arg Gly Pro Leu Ser Gln Ala Pro Glu Ala Ile                  85 90 95 Glu Glu Ala Ala Arg Ile Ser Gly Ala Gly Arg Leu Arg Ser Ile Met             100 105 110 Asp Thr Thr Gly Ala Met Ala Ile Pro Ala Ala Phe Ala Gly Ala Val         115 120 125 Leu Val Ala Val Thr Ala Val Arg Glu Leu Thr Val Ser Ile Leu Leu     130 135 140 Ile Ala Pro Gly Thr Thr Thr Leu Gly Val Gln Val Phe Asn Leu Gln 145 150 155 160 Gln Ala Gly Asn Tyr Asn Gln Ala Ser Ala Leu Ser Leu Met Phe Ala                 165 170 175 Ile Ile Gly Ile Val Ala Leu Ala Leu Thr Val Arg Ser Gln Lys Glu             180 185 190 Phe <210> 375 <211> 798 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (798) <223> FRXA00370 <400> 375 ggc aaa gcc cta tgg aat tcc gcc tat aca aca gtg ctt tct gcg gtg 48 Gly Lys Ala Leu Trp Asn Ser Ala Tyr Thr Thr Val Leu Ser Ala Val   1 5 10 15 ggc gcg acc att atc ggc acg atc atg gct ctc acg ctg gac cga act 96 Gly Ala Thr Ile Ile Gly Thr Ile Met Ala Leu Thr Leu Asp Arg Thr              20 25 30 gat gtt ttc ggg cgc acc gcg ttg cgg tta ttt ttg tta tcc ccg ctg 144 Asp Val Phe Gly Arg Thr Ala Leu Arg Leu Phe Leu Leu Ser Pro Leu          35 40 45 ttg atc cct ccg ttt att ggg gct att gcg tgg ttg cag ctg ttc ggg 192 Leu Ile Pro Pro Phe Ile Gly Ala Ile Ala Trp Leu Gln Leu Phe Gly      50 55 60 aag aac cag ggc atc aac cgg ttt ttc ggc acg gaa gtg tgg gat att 240 Lys Asn Gln Gly Ile Asn Arg Phe Phe Gly Thr Glu Val Trp Asp Ile  65 70 75 80 tac ggc gct gat ggt gtg aca ttt ttg ttg att gtg cac tcc tat ccc 288 Tyr Gly Ala Asp Gly Val Thr Phe Leu Leu Ile Val His Ser Tyr Pro                  85 90 95 act gtg tac atc att gtt tcg gca gct ctg agg caa ctt cct agt gat 336 Thr Val Tyr Ile Ile Val Ser Ala Ala Leu Arg Gln Leu Pro Ser Asp             100 105 110 ttg gag caa gct gca cgg atc gcg ggg gcg gat act ttt acg gtg ttg 384 Leu Glu Gln Ala Ala Arg Ile Ala Gly Ala Asp Thr Phe Thr Val Leu         115 120 125 cgc acc atc aca ctc cca ctg ctc aaa cct gca ttg ttg tcg gcg ttt 432 Arg Thr Ile Thr Leu Pro Leu Leu Lys Pro Ala Leu Leu Ser Ala Phe     130 135 140 act ctt acc aca gtg gcg aac ctc gcc gac ttt ggc att cca gct ctg 480 Thr Leu Thr Thr Val Ala Asn Leu Ala Asp Phe Gly Ile Pro Ala Leu 145 150 155 160 ttg gga tcg cca gcg cgt ttt gaa acc tta gcc acc atg att tat cgc 528 Leu Gly Ser Pro Ala Arg Phe Glu Thr Leu Ala Thr Met Ile Tyr Arg                 165 170 175 ttc atg gaa tcc ggc acc gtg agc aat cca ttg cag gtg gta tcc acc 576 Phe Met Glu Ser Gly Thr Val Ser Asn Pro Leu Gln Val Val Ser Thr             180 185 190 att ggc atc gtg ttg ttg ttc ctg gga atc gca gca gta acc gcg gat 624 Ile Gly Ile Val Leu Leu Phe Leu Gly Ile Ala Ala Val Thr Ala Asp         195 200 205 tat ctg gtg tct ttg tac gcg gca tca aag ttg caa gac gca gga aca 672 Tyr Leu Val Ser Leu Tyr Ala Ala Ser Lys Leu Gln Asp Ala Gly Thr     210 215 220 ccg cat cgc ttt act ctc aac aaa tca cga atc cca gtc agc gtg atc 720 Pro His Arg Phe Thr Leu Asn Lys Ser Arg Ile Pro Val Ser Val Ile 225 230 235 240 acg tgg atc atc gcg ttg atc atc acc gcc gcc ccg ctg ctg ggt ctg 768 Thr Trp Ile Ile Ala Leu Ile Ile Thr Ala Ala Pro Leu Leu Gly Leu                 245 250 255 gca tac aga gca tta ctg cct gcc cca ggt 798 Ala Tyr Arg Ala Leu Leu Pro Ala Pro Gly             260 265 <210> 376 <211> 266 <212> PRT <213> Corynebacterium glutamicum <400> 376 Gly Lys Ala Leu Trp Asn Ser Ala Tyr Thr Thr Val Leu Ser Ala Val   1 5 10 15 Gly Ala Thr Ile Ile Gly Thr Ile Met Ala Leu Thr Leu Asp Arg Thr              20 25 30 Asp Val Phe Gly Arg Thr Ala Leu Arg Leu Phe Leu Leu Ser Pro Leu          35 40 45 Leu Ile Pro Pro Phe Ile Gly Ala Ile Ala Trp Leu Gln Leu Phe Gly      50 55 60 Lys Asn Gln Gly Ile Asn Arg Phe Phe Gly Thr Glu Val Trp Asp Ile  65 70 75 80 Tyr Gly Ala Asp Gly Val Thr Phe Leu Leu Ile Val His Ser Tyr Pro                  85 90 95 Thr Val Tyr Ile Ile Val Ser Ala Ala Leu Arg Gln Leu Pro Ser Asp             100 105 110 Leu Glu Gln Ala Ala Arg Ile Ala Gly Ala Asp Thr Phe Thr Val Leu         115 120 125 Arg Thr Ile Thr Leu Pro Leu Leu Lys Pro Ala Leu Leu Ser Ala Phe     130 135 140 Thr Leu Thr Thr Val Ala Asn Leu Ala Asp Phe Gly Ile Pro Ala Leu 145 150 155 160 Leu Gly Ser Pro Ala Arg Phe Glu Thr Leu Ala Thr Met Ile Tyr Arg                 165 170 175 Phe Met Glu Ser Gly Thr Val Ser Asn Pro Leu Gln Val Val Ser Thr             180 185 190 Ile Gly Ile Val Leu Leu Phe Leu Gly Ile Ala Ala Val Thr Ala Asp         195 200 205 Tyr Leu Val Ser Leu Tyr Ala Ala Ser Lys Leu Gln Asp Ala Gly Thr     210 215 220 Pro His Arg Phe Thr Leu Asn Lys Ser Arg Ile Pro Val Ser Val Ile 225 230 235 240 Thr Trp Ile Ile Ala Leu Ile Ile Thr Ala Ala Pro Leu Leu Gly Leu                 245 250 255 Ala Tyr Arg Ala Leu Leu Pro Ala Pro Gly             260 265 <210> 377 <211> 749 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (726) <223> RXN01285 <400> 377 ctc aac gtc acc atc ccc gac aac acc ttc acc gcc atc atc ggc ccc 48 Leu Asn Val Thr Ile Pro Asp Asn Thr Phe Thr Ala Ile Gly Pro   1 5 10 15 aac ggc tgc ggc aaa tcc acc ctg ctc cgc ggt ttc tcc cgc gtg ctc 96 Asn Gly Cys Gly Lys Ser Thr Leu Leu Arg Gly Phe Ser Arg Val Leu              20 25 30 aat ccg cag cac ggc aaa gtg ctt ctc gac ggt cgg caa ctc gat tca 144 Asn Pro Gln His Gly Lys Val Leu Leu Asp Gly Arg Gln Leu Asp Ser          35 40 45 ttc aag cct aaa gag atc gcc cga gaa cta ggc ctg ctg cca cag acc 192 Phe Lys Pro Lys Glu Ile Ala Arg Glu Leu Gly Leu Leu Pro Gln Thr      50 55 60 tcc atc gcc cca gaa ggc atc cgg gtt tac gat ctc atc gcg cgc ggg 240 Ser Ile Ala Pro Glu Gly Ile Arg Val Tyr Asp Leu Ile Ala Arg Gly  65 70 75 80 cgc gct ccc tac caa agc ctc ata caa caa tgg cgc acc tcc gac gaa 288 Arg Ala Pro Tyr Gln Ser Leu Ile Gln Gln Trp Arg Thr Ser Asp Glu                  85 90 95 gac gcc gtc gcg caa gcg ctc gcc tcc acg aat ctc acc gaa ctt gca 336 Asp Ala Val Ala Gln Ala Leu Ala Ser Thr Asn Leu Thr Glu Leu Ala             100 105 110 gct cgc ctc gtc gat gaa ctc tcc ggt ggc cag cgc caa cga gtg tgg 384 Ala Arg Leu Val Asp Glu Leu Ser Gly Gly Gln Arg Gln Arg Val Trp         115 120 125 gtg gcc atg ttg ctc gcc cag caa aca ccg atc atg ctt ctc gac gag 432 Val Ala Met Leu Leu Ala Gln Gln Thr Pro Ile Met Leu Leu Asp Glu     130 135 140 ccc acc acc ttc ctc gac atc gcc cac caa tac gaa ctc ttg gaa ttg 480 Pro Thr Thr Phe Leu Asp Ile Ala His Gln Tyr Glu Leu Leu Glu Leu 145 150 155 160 ctg cgc gca ttc aac gag gcc ggg aaa act gtg gtc act gtg ctt cac 528 Leu Arg Ala Phe Asn Glu Ala Gly Lys Thr Val Val Thr Val Leu His                 165 170 175 gat ctc aac caa gcc gcc cgc tac gcc gac cac ctc atc gtg atg aaa 576 Asp Leu Asn Gln Ala Ala Arg Tyr Ala Asp His Leu Ile Val Met Lys             180 185 190 gat ggg cac gta cat gcc acg ggc aca ccg gag gaa gtc tta act gcc 624 Asp Gly His Val His Ala Thr Gly Thr Pro Glu Glu Val Leu Thr Ala         195 200 205 gag atg gtt caa gga gtt ttt ggc ctg ccc tgc atc atc tcc cca gac 672 Glu Met Val Gln Gly Val Phe Gly Leu Pro Cys Ile Ile Ser Pro Asp     210 215 220 ccc gtc aca gga acc ccc acc gtc gtt ccc ctc agt cgg tct cgc gca 720 Pro Val Thr Gly Thr Pro Thr Val Val Pro Leu Ser Arg Ser Arg Ala 225 230 235 240 gga gct taagtagcta cccctccaac gga 749 Gly ala <210> 378 <211> 242 <212> PRT <213> Corynebacterium glutamicum <400> 378 Leu Asn Val Thr Ile Pro Asp Asn Thr Phe Thr Ala Ile Gly Pro   1 5 10 15 Asn Gly Cys Gly Lys Ser Thr Leu Leu Arg Gly Phe Ser Arg Val Leu              20 25 30 Asn Pro Gln His Gly Lys Val Leu Leu Asp Gly Arg Gln Leu Asp Ser          35 40 45 Phe Lys Pro Lys Glu Ile Ala Arg Glu Leu Gly Leu Leu Pro Gln Thr      50 55 60 Ser Ile Ala Pro Glu Gly Ile Arg Val Tyr Asp Leu Ile Ala Arg Gly  65 70 75 80 Arg Ala Pro Tyr Gln Ser Leu Ile Gln Gln Trp Arg Thr Ser Asp Glu                  85 90 95 Asp Ala Val Ala Gln Ala Leu Ala Ser Thr Asn Leu Thr Glu Leu Ala             100 105 110 Ala Arg Leu Val Asp Glu Leu Ser Gly Gly Gln Arg Gln Arg Val Trp         115 120 125 Val Ala Met Leu Leu Ala Gln Gln Thr Pro Ile Met Leu Leu Asp Glu     130 135 140 Pro Thr Thr Phe Leu Asp Ile Ala His Gln Tyr Glu Leu Leu Glu Leu 145 150 155 160 Leu Arg Ala Phe Asn Glu Ala Gly Lys Thr Val Val Thr Val Leu His                 165 170 175 Asp Leu Asn Gln Ala Ala Arg Tyr Ala Asp His Leu Ile Val Met Lys             180 185 190 Asp Gly His Val His Ala Thr Gly Thr Pro Glu Glu Val Leu Thr Ala         195 200 205 Glu Met Val Gln Gly Val Phe Gly Leu Pro Cys Ile Ile Ser Pro Asp     210 215 220 Pro Val Thr Gly Thr Pro Thr Val Val Pro Leu Ser Arg Ser Arg Ala 225 230 235 240 Gly ala <210> 379 <211> 1149 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1126) <223> RXN00523 <400> 379 tggtgactcg tccgagtgaa attgccgtgg gcatcatcat gccgatcatt ggtgcgccac 60 tgtttatttg gattattcgt cgtcagaaag tcaaagagct atg agc ctt agc cat 115                                             Met Ser Leu Ser His                                               1 5 caa ctc aag cgc cag cgc gca tcg cgc aac tcc cgc agg tgg ctg att 163 Gln Leu Lys Arg Gln Arg Ala Ser Arg Asn Ser Arg Arg Trp Leu Ile                  10 15 20 gtt gcg gca ttg ggc gtc gtc acg ctt ggt att ttt gct ttt tct ttg 211 Val Ala Ala Leu Gly Val Val Thr Leu Gly Ile Phe Ala Phe Ser Leu              25 30 35 atg tgg ggc gag gtg ttt tat ggc cct gct cag gtg ctg aaa gtg ttg 259 Met Trp Gly Glu Val Phe Tyr Gly Pro Ala Gln Val Leu Lys Val Leu          40 45 50 tct gga cag cag gtt ccc ggc gcg agt tat tcc gtt ggc gtg ttg cgt 307 Ser Gly Gln Gln Val Pro Gly Ala Ser Tyr Ser Val Gly Val Leu Arg      55 60 65 ttg ccg cgc gcg gtg atg ggt ttg act gcg ggt ttg gcg ttt ggc gcg 355 Leu Pro Arg Ala Val Met Gly Leu Thr Ala Gly Leu Ala Phe Gly Ala  70 75 80 85 gcg ggc gtg att ttt cag acg gtg ttg cgt aat cag ttg gcg tcg ccg 403 Ala Gly Val Ile Phe Gln Thr Val Leu Arg Asn Gln Leu Ala Ser Pro                  90 95 100 gat att atc ggc att tct tct ggc gcg tcg gcg gcg ggc gta att tgc 451 Asp Ile Ile Gly Ile Ser Ser Gly Ala Ser Ala Ala Gly Val Ile Cys             105 110 115 att gtg ttt ttc ggg atg tcg cag tct gca gtg tcg gcg att tct ttg 499 Ile Val Phe Phe Gly Met Ser Gln Ser Ala Val Ser Ala Ile Ser Leu         120 125 130 tgt gcg tcc ttg gct gtg gcg ttg ttg att tat ctg gtg gcg tat cgc 547 Cys Ala Ser Leu Ala Val Ala Leu Leu Ile Tyr Leu Val Ala Tyr Arg     135 140 145 ggt ggt ttt tcg gcc acg cgt ctg att ctt acc ggc att ggt att gct 595 Gly Gly Phe Ser Ala Thr Arg Leu Ile Leu Thr Gly Ile Gly Ile Ala 150 155 160 165 gcg atg ctg aat tca tta gtg tcg tat tcg ctg tcc aag gct gat tct 643 Ala Met Leu Asn Ser Leu Val Ser Tyr Ser Leu Ser Lys Ala Asp Ser                 170 175 180 tgg gat ctg ccg acc gcg acg cgc tgg ctt acc ggc tcg ctc aat ggt 691 Trp Asp Leu Pro Thr Ala Thr Arg Trp Leu Thr Gly Ser Leu Asn Gly             185 190 195 gcg acg tgg gat cgt gcg atg ccg ctg att gtc acc act gtg gta ctc 739 Ala Thr Trp Asp Arg Ala Met Pro Leu Ile Val Thr Thr Val Val Leu         200 205 210 att ccg ctg ctg gtg gct aat gcg cgc aat gtg gat ctt atg cgt ttg 787 Ile Pro Leu Leu Val Ala Asn Ala Arg Asn Val Asp Leu Met Arg Leu     215 220 225 ggc aat gat tcc gcg gtg ggt ttg ggc gtt gct act aat cgc acg cgc 835 Gly Asn Asp Ser Ala Val Gly Leu Gly Val Ala Thr Asn Arg Thr Arg 230 235 240 245 gtc att gcg att att gcc gct gtt gcg ctc atc gcc gtt gct acc gct 883 Val Ile Ala Ile Ile Ala Ala Val Ala Leu Ile Ala Val Ala Thr Ala                 250 255 260 gca tgc ggc ccg atc gca ttc gtg gcg ttt gtg tct ggc ccc att gcc 931 Ala Cys Gly Pro Ile Ala Phe Val Ala Phe Val Ser Gly Pro Ile Ala             265 270 275 gcg cgc att tta ggc tcc ggc gga tcg ctc atc atc ccc tcc gca ctc 979 Ala Arg Ile Leu Gly Ser Gly Gly Ser Leu Ile Ile Pro Ser Ala Leu         280 285 290 atc ggc ggg ttg atc gtg ctc atc gcc gac cta att ggc caa tac ttc 1027 Ile Gly Gly Leu Ile Val Leu Ile Ala Asp Leu Ile Gly Gln Tyr Phe     295 300 305 ctc ggc acc cgc tac ccc gtc gga gtt gtc acc ggc gca ttc ggc gcc 1075 Leu Gly Thr Arg Tyr Pro Val Gly Val Val Thr Gly Ala Phe Gly Ala 310 315 320 325 cca ttc ctt atc tat tta ctc att cgt tcc aac cgc gcg gga gta acc 1123 Pro Phe Leu Ile Tyr Leu Leu Ile Arg Ser Asn Arg Ala Gly Val Thr                 330 335 340 ctg tgaccaccaa ccatcaacta tcc 1149 Leu <210> 380 <211> 342 <212> PRT <213> Corynebacterium glutamicum <400> 380 Met Ser Leu Ser His Gln Leu Lys Arg Gln Arg Ala Ser Arg Asn Ser   1 5 10 15 Arg Arg Trp Leu Ile Val Ala Ala Leu Gly Val Val Thr Leu Gly Ile              20 25 30 Phe Ala Phe Ser Leu Met Trp Gly Glu Val Phe Tyr Gly Pro Ala Gln          35 40 45 Val Leu Lys Val Leu Ser Gly Gln Gln Val Pro Gly Ala Ser Tyr Ser      50 55 60 Val Gly Val Leu Arg Leu Pro Arg Ala Val Met Gly Leu Thr Ala Gly  65 70 75 80 Leu Ala Phe Gly Ala Ala Gly Val Ile Phe Gln Thr Val Leu Arg Asn                  85 90 95 Gln Leu Ala Ser Pro Asp Ile Ile Gly Ile Ser Ser Gly Ala Ser Ala             100 105 110 Ala Gly Val Ile Cys Ile Val Phe Phe Gly Met Ser Gln Ser Ala Val         115 120 125 Ser Ala Ile Ser Leu Cys Ala Ser Leu Ala Val Ala Leu Leu Ile Tyr     130 135 140 Leu Val Ala Tyr Arg Gly Gly Phe Ser Ala Thr Arg Leu Ile Leu Thr 145 150 155 160 Gly Ile Gly Ile Ala Ala Met Leu Asn Ser Leu Val Ser Tyr Ser Leu                 165 170 175 Ser Lys Ala Asp Ser Trp Asp Leu Pro Thr Ala Thr Arg Trp Leu Thr             180 185 190 Gly Ser Leu Asn Gly Ala Thr Trp Asp Arg Ala Met Pro Leu Ile Val         195 200 205 Thr Thr Val Val Leu Ile Pro Leu Leu Val Ala Asn Ala Arg Asn Val     210 215 220 Asp Leu Met Arg Leu Gly Asn Asp Ser Ala Val Gly Leu Gly Val Ala 225 230 235 240 Thr Asn Arg Thr Arg Val Ile Ala Ile Ile Ala Ala Val Ala Leu Ile                 245 250 255 Ala Val Ala Thr Ala Ala Cys Gly Pro Ile Ala Phe Val Ala Phe Val             260 265 270 Ser Gly Pro Ile Ala Ala Arg Ile Leu Gly Ser Gly Gly Ser Leu Ile         275 280 285 Ile Pro Ser Ala Leu Ile Gly Gly Leu Ile Val Leu Ile Ala Asp Leu     290 295 300 Ile Gly Gln Tyr Phe Leu Gly Thr Arg Tyr Pro Val Gly Val Val Thr 305 310 315 320 Gly Ala Phe Gly Ala Pro Phe Leu Ile Tyr Leu Leu Ile Arg Ser Asn                 325 330 335 Arg Ala Gly Val Thr Leu             340 <210> 381 <211> 621 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (598) <223> RXN01142 <400> 381 ctccccatcc accggcacag tcagcgcagg caacgaagaa attaaaggac caggacctga 60 ccgaggcatg gttttccaag accacgccct cctgccctga ttg acc gca cgc ggc 115                                             Leu Thr Ala Arg Gly                                               1 5 aac atc gac ttc ggg ctc cgc tcc gcg cgc ccc tcc ttg agc aaa acc 163 Asn Ile Asp Phe Gly Leu Arg Ser Ala Arg Pro Ser Leu Ser Lys Thr                  10 15 20 gaa cgc gcc gac atc acc cgc acc cac ctc gaa caa gta ggc ctc acc 211 Glu Arg Ala Asp Ile Thr Arg Thr His Leu Glu Gln Val Gly Leu Thr              25 30 35 gac gcc gcc gaa cgg cgc ccc gcc cgc ctc tcc ggc ggc atg caa cag 259 Asp Ala Ala Glu Arg Arg Pro Ala Arg Leu Ser Gly Gly Met Gln Gln          40 45 50 cga gtc ggc atc gca cgc gcc ttc gcc atc gac cca cca atc atg ctt 307 Arg Val Gly Ile Ala Arg Ala Phe Ala Ile Asp Pro Pro Ile Met Leu      55 60 65 ctc gac gaa ccc ttc ggc gcc ctc gac gcc ctc acc cgc cgc gaa ctc 355 Leu Asp Glu Pro Phe Gly Ala Leu Asp Ala Leu Thr Arg Arg Glu Leu  70 75 80 85 cag ctc caa cta ctc aac att tgg gaa gcc tcc cgc cgc acc gtc gtc 403 Gln Leu Gln Leu Leu Asn Ile Trp Glu Ala Ser Arg Arg Thr Val Val                  90 95 100 atg gtc acc cac gac gtc gac gag gcc atc ctg ctc tcc gac cga gtt 451 Met Val Thr His Asp Val Asp Glu Ala Ile Leu Leu Ser Asp Arg Val             105 110 115 ctc gtg atg tcc aag agc ccc gaa gcc acc atc atc acc gat att cca 499 Leu Val Met Ser Lys Ser Pro Glu Ala Thr Ile Ile Thr Asp Ile Pro         120 125 130 gtg aat ctt ccc cgc ccc aga cac gag ctg agt gaa gac gct tct gtt 547 Val Asn Leu Pro Arg Pro Arg His Glu Leu Ser Glu Asp Ala Ser Val     135 140 145 gaa gcc gag acc aca gcc ctg cgt aag cgg atg ctg cat ctg ctg gag 595 Glu Ala Glu Thr Thr Ala Leu Arg Lys Arg Met Leu His Leu Leu Glu 150 155 160 165 cac tagtttctaa cacgtctttt aaa 621 His <210> 382 <211> 166 <212> PRT <213> Corynebacterium glutamicum <400> 382 Leu Thr Ala Arg Gly Asn Ile Asp Phe Gly Leu Arg Ser Ala Arg Pro   1 5 10 15 Ser Leu Ser Lys Thr Glu Arg Ala Asp Ile Thr Arg Thr His Leu Glu              20 25 30 Gln Val Gly Leu Thr Asp Ala Ala Glu Arg Arg Pro Ala Arg Leu Ser          35 40 45 Gly Gly Met Gln Gln Arg Val Gly Ile Ala Arg Ala Phe Ala Ile Asp      50 55 60 Pro Pro Ile Met Leu Leu Asp Glu Pro Phe Gly Ala Leu Asp Ala Leu  65 70 75 80 Thr Arg Arg Glu Leu Gln Leu Gln Leu Leu Asn Ile Trp Glu Ala Ser                  85 90 95 Arg Arg Thr Val Val Met Val Thr His Asp Val Asp Glu Ala Ile Leu             100 105 110 Leu Ser Asp Arg Val Leu Val Met Ser Lys Ser Pro Glu Ala Thr Ile         115 120 125 Ile Thr Asp Ile Pro Val Asn Leu Pro Arg Pro Arg His Glu Leu Ser     130 135 140 Glu Asp Ala Ser Val Glu Ala Glu Thr Thr Ala Leu Arg Lys Arg Met 145 150 155 160 Leu His Leu Leu Glu His                 165 <210> 383 <211> 948 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (925) <223> RXN01141 <400> 383 aaagaacact cggtatggca cctgatttaa ggatgctgca atcgtgacac atatcctctt 60 cgacagcagg cgttttctgc aactgggcgc ttttgcgtcc ttg agc acc gca ttg 115                                             Leu Ser Thr Ala Leu                                               1 5 gcc gga gcg gcc cgc tac gtg acg tcg aca agc aat aat gaa cct gcg 163 Ala Gly Ala Ala Arg Tyr Val Thr Ser Thr Ser Asn Asn Glu Pro Ala                  10 15 20 gat aac act ccc ctg acc att ggc tac gtg cct att gcg ggc tcg gcg 211 Asp Asn Thr Pro Leu Thr Ile Gly Tyr Val Pro Ile Ala Gly Ser Ala              25 30 35 ccg att gct atc gca gat gcg cta ggg ctg ttt aag aaa cac ggc gtg 259 Pro Ile Ala Ile Ala Asp Ala Leu Gly Leu Phe Lys Lys His Gly Val          40 45 50 aat gtc acg ttg aag aag tac tca ggc tgg tcc gac ctg tgg acc gcc 307 Asn Val Thr Leu Lys Lys Tyr Ser Gly Trp Ser Asp Leu Trp Thr Ala      55 60 65 tat gca aca gag cag ctt gat gtt gcg cac atg ctg tcg ccg atg act 355 Tyr Ala Thr Glu Gln Leu Asp Val Ala His Met Leu Ser Pro Met Thr  70 75 80 85 gtg gcg att aat gct gga gtg acc aac gcg tcg cgc ccg acg gag ctg 403 Val Ala Ile Asn Ala Gly Val Thr Asn Ala Ser Arg Pro Thr Glu Leu                  90 95 100 tcg ttt acc cag aac acc aat ggg caa gca att acc ttg gcg tca aag 451 Ser Phe Thr Gln Asn Thr Asn Gly Gln Ala Ile Thr Leu Ala Ser Lys             105 110 115 cac tat ggt tcc gtc aat tca gcg gcg gat ctt aaa ggc atg gtg ctg 499 His Tyr Gly Ser Val Asn Ser Ala Ala Asp Leu Lys Gly Met Val Leu         120 125 130 gga att cct ttt gaa tat tca gtc cat gcg ctg ctc ctg cgc gat tat 547 Gly Ile Pro Phe Glu Tyr Ser Val His Ala Leu Leu Leu Arg Asp Tyr     135 140 145 ctc gtc tca aac gca gtt gat ccc atc gcc gat ctt gag ctt cgc ctg 595 Leu Val Ser Asn Ala Val Asp Pro Ile Ala Asp Leu Glu Leu Arg Leu 150 155 160 165 ctc cga cct gcc gat atg gtc gca caa ttg aca gtt gag ggc atc gat 643 Leu Arg Pro Ala Asp Met Val Ala Gln Leu Thr Val Glu Gly Ile Asp                 170 175 180 gga ttc att ggg cct ggg ccg ttt aat gaa cgc gcc atc agc aat ggc 691 Gly Phe Ile Gly Pro Gly Pro Phe Asn Glu Arg Ala Ile Ser Asn Gly             185 190 195 tcc ggc cgg att tgg ctg ctg acc aaa caa ctg tgg gac aaa cat cca 739 Ser Gly Arg Ile Trp Leu Leu Thr Lys Gln Leu Trp Asp Lys His Pro         200 205 210 tgc tgc gcc gtg gcg atg gcc aaa gag tgg aaa gct gaa cac ccc acg 787 Cys Cys Ala Val Ala Met Ala Lys Glu Trp Lys Ala Glu His Pro Thr     215 220 225 gcg gct cag ggt gtg ctt aat gcg ctg gag gaa gcc tcc gca att ttg 835 Ala Ala Gln Gly Val Leu Asn Ala Leu Glu Glu Ala Ser Ala Ile Leu 230 235 240 245 agc aat ccg gca caa ttt gat tcc tcg gca cgc acg ctg tcg cag gaa 883 Ser Asn Pro Ala Gln Phe Asp Ser Ser Ala Arg Thr Leu Ser Gln Glu                 250 255 260 aaa tac ctc aac cag cct gcc acg ttg ctg gat gga ccg tcg 925 Lys Tyr Leu Asn Gln Pro Ala Thr Leu Leu Asp Gly Pro Ser             265 270 275 taatcatcgg catcaccggc tta 948 <210> 384 <211> 275 <212> PRT <213> Corynebacterium glutamicum <400> 384 Leu Ser Thr Ala Leu Ala Gly Ala Ala Arg Tyr Val Thr Ser Thr Ser   1 5 10 15 Asn Asn Glu Pro Ala Asp Asn Thr Pro Leu Thr Ile Gly Tyr Val Pro              20 25 30 Ile Ala Gly Ser Ala Pro Ile Ala Ile Ala Asp Ala Leu Gly Leu Phe          35 40 45 Lys Lys His Gly Val Asn Val Thr Leu Lys Lys Tyr Ser Gly Trp Ser      50 55 60 Asp Leu Trp Thr Ala Tyr Ala Thr Glu Gln Leu Asp Val Ala His Met  65 70 75 80 Leu Ser Pro Met Thr Val Ala Ile Asn Ala Gly Val Thr Asn Ala Ser                  85 90 95 Arg Pro Thr Glu Leu Ser Phe Thr Gln Asn Thr Asn Gly Gln Ala Ile             100 105 110 Thr Leu Ala Ser Lys His Tyr Gly Ser Val Asn Ser Ala Ala Asp Leu         115 120 125 Lys Gly Met Val Leu Gly Ile Pro Phe Glu Tyr Ser Val His Ala Leu     130 135 140 Leu Leu Arg Asp Tyr Leu Val Ser Asn Ala Val Asp Pro Ile Ala Asp 145 150 155 160 Leu Glu Leu Arg Leu Leu Arg Pro Ala Asp Met Val Ala Gln Leu Thr                 165 170 175 Val Glu Gly Ile Asp Gly Phe Ile Gly Pro Gly Pro Phe Asn Glu Arg             180 185 190 Ala Ile Ser Asn Gly Ser Gly Arg Ile Trp Leu Leu Thr Lys Gln Leu         195 200 205 Trp Asp Lys His Pro Cys Cys Ala Val Ala Met Ala Lys Glu Trp Lys     210 215 220 Ala Glu His Pro Thr Ala Ala Gln Gly Val Leu Asn Ala Leu Glu Glu 225 230 235 240 Ala Ser Ala Ile Leu Ser Asn Pro Ala Gln Phe Asp Ser Ser Ala Arg                 245 250 255 Thr Leu Ser Gln Glu Lys Tyr Leu Asn Gln Pro Ala Thr Leu Leu Asp             260 265 270 Gly pro ser         275 <210> 385 <211> 927 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (904) <223> RXN01002 <400> 385 gactgctgat accgcacagg atgaaatcac tcgttacggc gagatcctga agaagttctc 60 caactaattt ccctgtttcc aatactcaag gtgtgcgcat atg aat tct gat gct 115                                             Met Asn Ser Asp Ala                                               1 5 tcg gct acc acc aac tcc tgg gct atc aac ttc gac cat gtg tcg gtg 163 Ser Ala Thr Thr Asn Ser Trp Ala Ile Asn Phe Asp His Val Ser Val                  10 15 20 acg tat ccc aat ggg acg aaa gcc ctc gat gat gtt tcc ctc acc atc 211 Thr Tyr Pro Asn Gly Thr Lys Ala Leu Asp Asp Val Ser Leu Thr Ile              25 30 35 aat ccc ggt gag atg gtt gcc atc gtg ggt ctg tca gga tcg ggt aaa 259 Asn Pro Gly Glu Met Val Ala Ile Val Gly Leu Ser Gly Ser Gly Lys          40 45 50 tcc acg ctg att cgc acg atc aac ggt ctt gtc cgc gct acg gaa ggc 307 Ser Thr Leu Ile Arg Thr Ile Asn Gly Leu Val Arg Ala Thr Glu Gly      55 60 65 acc gtg acg gtg ggg ccg cat cag atc aac acc ttg aag ggg aaa gca 355 Thr Val Thr Val Gly Pro His Gln Ile Asn Thr Leu Lys Gly Lys Ala  70 75 80 85 ctg cgt gat gcc cgt ggg cag atc ggc atg att ttc cag ggg ttc aac 403 Leu Arg Asp Ala Arg Gly Gln Ile Gly Met Ile Phe Gln Gly Phe Asn                  90 95 100 ctg tcg gaa cgc agc agt gtg ttc cag aat gtt ttg gtg ggc cgc ttc 451 Leu Ser Glu Arg Ser Ser Val Phe Gln Asn Val Leu Val Gly Arg Phe             105 110 115 gcg cac aca gcg tgg tgg cgt aac ctc ctc ggg ttt ccc acg gag cac 499 Ala His Thr Ala Trp Trp Arg Asn Leu Leu Gly Phe Pro Thr Glu His         120 125 130 gac aag cag att gct ttt cac gcg ttg gag tcc gtg ggc att ttg cac 547 Asp Lys Gln Ile Ala Phe His Ala Leu Glu Ser Val Gly Ile Leu His     135 140 145 aaa gtg tgg acc cga gct ggt gct ttg tcg ggt gga cag aaa cag cgc 595 Lys Val Trp Thr Arg Ala Gly Ala Leu Ser Gly Gly Gln Lys Gln Arg 150 155 160 165 gtt gct att gcg cgc gcc tta tcg caa gat ccg tct gtc atg ctg gca 643 Val Ala Ile Ala Arg Ala Leu Ser Gln Asp Pro Ser Val Met Leu Ala                 170 175 180 gat gag cct gtg gca agc ctt gat ccg cca acc gcg cat tcc gtg atg 691 Asp Glu Pro Val Ala Ser Leu Asp Pro Pro Thr Ala His Ser Val Met             185 190 195 cgc gat cta gaa aac atc aac aac gtg gaa ggc ctc acc gtg ttg gtg 739 Arg Asp Leu Glu Asn Ile Asn Asn Val Glu Gly Leu Thr Val Leu Val         200 205 210 aac ttg cac ttg att gat ttg gct cgt caa tac acc aca agg ctt gtg 787 Asn Leu His Leu Ile Asp Leu Ala Arg Gln Tyr Thr Thr Arg Leu Val     215 220 225 ggt ttg cgt gcc ggc aag ctg gtc tat gac ggt cct atc tct gag gcc 835 Gly Leu Arg Ala Gly Lys Leu Val Tyr Asp Gly Pro Ile Ser Glu Ala 230 235 240 245 acc gat aaa gac ttt gaa gct atc tat ggt cgc ccc atc cag gct aaa 883 Thr Asp Lys Asp Phe Glu Ala Ile Tyr Gly Arg Pro Ile Gln Ala Lys                 250 255 260 gac ctg cta ggt gat cgc gca tgaccacgcc ttcttctaca ctt 927 Asp Leu Leu Gly Asp Arg Ala             265 <210> 386 <211> 268 <212> PRT <213> Corynebacterium glutamicum <400> 386 Met Asn Ser Asp Ala Ser Ala Thr Thr Asn Ser Trp Ala Ile Asn Phe   1 5 10 15 Asp His Val Ser Val Thr Tyr Pro Asn Gly Thr Lys Ala Leu Asp Asp              20 25 30 Val Ser Leu Thr Ile Asn Pro Gly Glu Met Val Ala Ile Val Gly Leu          35 40 45 Ser Gly Ser Gly Lys Ser Thr Leu Ile Arg Thr Ile Asn Gly Leu Val      50 55 60 Arg Ala Thr Glu Gly Thr Val Thr Val Gly Pro His Gln Ile Asn Thr  65 70 75 80 Leu Lys Gly Lys Ala Leu Arg Asp Ala Arg Gly Gln Ile Gly Met Ile                  85 90 95 Phe Gln Gly Phe Asn Leu Ser Glu Arg Ser Ser Val Phe Gln Asn Val             100 105 110 Leu Val Gly Arg Phe Ala His Thr Ala Trp Trp Arg Asn Leu Leu Gly         115 120 125 Phe Pro Thr Glu His Asp Lys Gln Ile Ala Phe His Ala Leu Glu Ser     130 135 140 Val Gly Ile Leu His Lys Val Trp Thr Arg Ala Gly Ala Leu Ser Gly 145 150 155 160 Gly Gln Lys Gln Arg Val Ala Ile Ala Arg Ala Leu Ser Gln Asp Pro                 165 170 175 Ser Val Met Leu Ala Asp Glu Pro Val Ala Ser Leu Asp Pro Pro Thr             180 185 190 Ala His Ser Val Met Arg Asp Leu Glu Asn Ile Asn Asn Val Glu Gly         195 200 205 Leu Thr Val Leu Val Asn Leu His Leu Ile Asp Leu Ala Arg Gln Tyr     210 215 220 Thr Thr Arg Leu Val Gly Leu Arg Ala Gly Lys Leu Val Tyr Asp Gly 225 230 235 240 Pro Ile Ser Glu Ala Thr Asp Lys Asp Phe Glu Ala Ile Tyr Gly Arg                 245 250 255 Pro Ile Gln Ala Lys Asp Leu Leu Gly Asp Arg Ala             260 265 <210> 387 <211> 969 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (946) <223> RXN01000 <400> 387 ctttctatgc ctacgcggat gtttccgtga tcattctgga aatcctcatc gtggtgattg 60 tcattgaagt aatctccaac gcacttcgaa agaggctggt atg agc acc tta acc 115                                             Met Ser Thr Leu Thr                                               1 5 tct cac cgc aca gta ccg gcc ccc agc tct ccc ccg gcg cgc ccc aac 163 Ser His Arg Thr Val Pro Ala Pro Ser Ser Pro Pro Ala Arg Pro Asn                  10 15 20 aaa ctg gcg cgc aat atc gtt gca att gtc gct gcg ctg att gtc ctt 211 Lys Leu Ala Arg Asn Ile Val Ala Ile Val Ala Ala Leu Ile Val Leu              25 30 35 ata gct acc ggc acg ctc aag atc gag tgg aat gag ctt ccg cag atg 259 Ile Ala Thr Gly Thr Leu Lys Ile Glu Trp Asn Glu Leu Pro Gln Met          40 45 50 ccc gcg cag gtg tgg cat tac tta gag ctg atg ttt agc gat ccc gat 307 Pro Ala Gln Val Trp His Tyr Leu Glu Leu Met Phe Ser Asp Pro Asp      55 60 65 tgg tcg aag ttt ggc cgc gcc gtc cag gaa atg tgg cgt tcc atc gcc 355 Trp Ser Lys Phe Gly Arg Ala Val Gln Glu Met Trp Arg Ser Ile Ala  70 75 80 85 atg gcg tgg ttg ggt gcc att tta tgc gtg gtg gtc tct gtc cct ctg 403 Met Ala Trp Leu Gly Ala Ile Leu Cys Val Val Val Ser Val Pro Leu                  90 95 100 gga atg ttg gct gcc cgc ggg gtg gga cct tat tgg ctg cgt acc gtt 451 Gly Met Leu Ala Ala Arg Gly Val Gly Pro Tyr Trp Leu Arg Thr Val             105 110 115 tta cgg ttc gtg ttc gcg gtg att cgt gcg ttc ccc gaa gtg gtt atc 499 Leu Arg Phe Val Phe Ala Val Ile Arg Ala Phe Pro Glu Val Val Ile         120 125 130 gca att att ttg cta act gtc acc ggc cta act cct ttt act ggt gcg 547 Ala Ile Ile Leu Leu Thr Val Thr Gly Leu Thr Pro Phe Thr Gly Ala     135 140 145 ctc gca ttg ggt atc tcc ggt att gga caa cag gca aag tgg acc tat 595 Leu Ala Leu Gly Ile Ser Gly Ile Gly Gln Gln Ala Lys Trp Thr Tyr 150 155 160 165 gaa gcc att gag tcc act ccc acc ggc ccg tca gag gca gtg cgt gca 643 Glu Ala Ile Glu Ser Thr Pro Thr Gly Pro Ser Glu Ala Val Arg Ala                 170 175 180 gcg ggt gga act acg ccg gag gtt ctg cgg tgg gcg ttg tgg cca cag 691 Ala Gly Gly Thr Thr Pro Glu Val Leu Arg Trp Ala Leu Trp Pro Gln             185 190 195 gtt gcg cca tcc att gca tct ttt gcc ctg tac cgc ttt gag atc aac 739 Val Ala Pro Ser Ile Ala Ser Phe Ala Leu Tyr Arg Phe Glu Ile Asn         200 205 210 atc cgt acc tct gcg gta ttg ggc atc gtt ggt gca ggt ggt atc ggt 787 Ile Arg Thr Ser Ala Val Leu Gly Ile Val Gly Ala Gly Gly Ile Gly     215 220 225 agt atg ctt gcc aat tac acc aac tac agg cag tgg gac acc gtg ggc 835 Ser Met Leu Ala Asn Tyr Thr Asn Tyr Arg Gln Trp Asp Thr Val Gly 230 235 240 245 atg ctg ctc atc gtc gtg gtt gtc gca acg atg atc gtc gat ctc atc 883 Met Leu Leu Ile Val Val Val Val Ala Thr Met Ile Val Asp Leu Ile                 250 255 260 tcc ggc acc atc cgc cgc cgc atc atg aag ggg gct agt gac cgt gtc 931 Ser Gly Thr Ile Arg Arg Arg Ile Met Lys Gly Ala Ser Asp Arg Val             265 270 275 gtg gca cca agc aac tgacgctcca ccaagcatcc gca 969 Val Ala Pro Ser Asn         280 <210> 388 <211> 282 <212> PRT <213> Corynebacterium glutamicum <400> 388 Met Ser Thr Leu Thr Ser His Arg Thr Val Pro Ala Pro Ser Ser Pro   1 5 10 15 Pro Ala Arg Pro Asn Lys Leu Ala Arg Asn Ile Val Ala Ile Val Ala              20 25 30 Ala Leu Ile Val Leu Ile Ala Thr Gly Thr Leu Lys Ile Glu Trp Asn          35 40 45 Glu Leu Pro Gln Met Pro Ala Gln Val Trp His Tyr Leu Glu Leu Met      50 55 60 Phe Ser Asp Pro Asp Trp Ser Lys Phe Gly Arg Ala Val Gln Glu Met  65 70 75 80 Trp Arg Ser Ile Ala Met Ala Trp Leu Gly Ala Ile Leu Cys Val Val                  85 90 95 Val Ser Val Pro Leu Gly Met Leu Ala Ala Arg Gly Val Gly Pro Tyr             100 105 110 Trp Leu Arg Thr Val Leu Arg Phe Val Phe Ala Val Ile Arg Ala Phe         115 120 125 Pro Glu Val Val Ile Ala Ile Ile Leu Leu Thr Val Thr Gly Leu Thr     130 135 140 Pro Phe Thr Gly Ala Leu Ala Leu Gly Ile Ser Gly Ile Gly Gln Gln 145 150 155 160 Ala Lys Trp Thr Tyr Glu Ala Ile Glu Ser Thr Pro Thr Gly Pro Ser                 165 170 175 Glu Ala Val Arg Ala Ala Gly Gly Thr Thr Pro Glu Val Leu Arg Trp             180 185 190 Ala Leu Trp Pro Gln Val Ala Pro Ser Ile Ala Ser Phe Ala Leu Tyr         195 200 205 Arg Phe Glu Ile Asn Ile Arg Thr Ser Ala Val Leu Gly Ile Val Gly     210 215 220 Ala Gly Gly Ile Gly Ser Met Leu Ala Asn Tyr Thr Asn Tyr Arg Gln 225 230 235 240 Trp Asp Thr Val Gly Met Leu Leu Ile Val Val Val Val Ala Thr Met                 245 250 255 Ile Val Asp Leu Ile Ser Gly Thr Ile Arg Arg Arg Ile Met Lys Gly             260 265 270 Ala Ser Asp Arg Val Val Ala Pro Ser Asn         275 280 <210> 389 <211> 1173 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (1150) <223> RXN01732 <400> 389 gattctatcg ctgatctccc tctccttgcc tgggtttgtt cccgggtctc ctcttcttaa 60 ctttcttgtc tcatgtcgct gaaaggtttt taaagatctc atg ttc aag ctc tct 115                                             Met Phe Lys Leu Ser                                               1 5 aag cca tcc aag tcc atg cgt gtt gct gtt tct acg ctt gcg atc tct 163 Lys Pro Ser Lys Ser Met Arg Val Ala Val Ser Thr Leu Ala Ile Ser                  10 15 20 acc ctt gct cta gtt ggt tgt tcc tct tcc gat gag tct tct tcc tca 211 Thr Leu Ala Leu Val Gly Cys Ser Ser Ser Asp Glu Ser Ser Ser Ser              25 30 35 tca tct gcg tct tct tct tcg gat gct gca agc cag tgg cct gag tcc 259 Ser Ser Ala Ser Ser Ser Ser Asp Ala Ala Ser Gln Trp Pro Glu Ser          40 45 50 att act ttg tct ctt gtt cct tct act gag ggt gag gat ttg gct gaa 307 Ile Thr Leu Ser Leu Val Pro Ser Thr Glu Gly Glu Asp Leu Ala Glu      55 60 65 gcg ttg gct cct ttg act gat tac ctg tct gag aac ctt ggt att gag 355 Ala Leu Ala Pro Leu Thr Asp Tyr Leu Ser Glu Asn Leu Gly Ile Glu  70 75 80 85 gtc aat ggt gtg gtg gcg tct gat tac gct gca acc gtt gag gct ttg 403 Val Asn Gly Val Val Ala Ser Asp Tyr Ala Ala Thr Val Glu Ala Leu                  90 95 100 ggt gct gat cag gct cag gtg atc atc act gat gcg ggt tcc ctg tat 451 Gly Ala Asp Gln Ala Gln Val Ile Ile Thr Asp Ala Gly Ser Leu Tyr             105 110 115 aac gcg att gag cag tac gat gcg cag ctg att ctg cgt gat gtg cgt 499 Asn Ala Ile Glu Gln Tyr Asp Ala Gln Leu Ile Leu Arg Asp Val Arg         120 125 130 ttc ggt gcc acc tcg tac tct gct gtg gcg tac acc aac aat cct gat 547 Phe Gly Ala Thr Ser Tyr Ser Ala Val Ala Tyr Thr Asn Asn Pro Asp     135 140 145 aag tac tgc gac gat gcc cca gtg gct gcg tct tat gct gcg tcc gat 595 Lys Tyr Cys Asp Asp Ala Pro Val Ala Ala Ser Tyr Ala Ala Ser Asp 150 155 160 165 gta gac atg ctt tac tgc aac ggt att gaa act gag ggc cag gct gct 643 Val Asp Met Leu Tyr Cys Asn Gly Ile Glu Thr Glu Gly Gln Ala Ala                 170 175 180 acc ggt gag ggc cca gca gct ctt gat gcg ctg gaa aag atc gag tcc 691 Thr Gly Glu Gly Pro Ala Ala Leu Asp Ala Leu Glu Lys Ile Glu Ser             185 190 195 ggt gac aag gta gcg ctg cag gct gca acc tct cct gcg ggt tac cag 739 Gly Asp Lys Val Ala Leu Gln Ala Ala Thr Ser Pro Ala Gly Tyr Gln         200 205 210 tac cct atc gtc gct atg cag gat ctg ggc atg gat acc gat tcc gct 787 Tyr Pro Ile Val Ala Met Gln Asp Leu Gly Met Asp Thr Asp Ser Ala     215 220 225 ttt gtt cag gtt cca gta gag ggc aac aac aac gct gtg ctg tct gtc 835 Phe Val Gln Val Pro Val Glu Gly Asn Asn Asn Ala Val Leu Ser Val 230 235 240 245 ctg aac ggt gac gcg gaa gtg tcc ttc ggt ttc tgg gat gcg cgt tcc 883 Leu Asn Gly Asp Ala Glu Val Ser Phe Gly Phe Trp Asp Ala Arg Ser                 250 255 260 acc gtg ctg tct gag gct cct aac gca gct gag gat gtc gta gcg ttt 931 Thr Val Leu Ser Glu Ala Pro Asn Ala Ala Glu Asp Val Val Ala Phe             265 270 275 gcc tac acc gag atg atc cct aac ggt ggc gtc gca gcg tcc aag tcc 979 Ala Tyr Thr Glu Met Ile Pro Asn Gly Gly Val Ala Ala Ser Lys Ser         280 285 290 ctt cca tcc gac ctg gtg gaa aag ctc acc gag ttg atg gat gat tac 1027 Leu Pro Ser Asp Leu Val Glu Lys Leu Thr Glu Leu Met Asp Asp Tyr     295 300 305 gca gat tcc tcc gag gaa gcc aag gat gtc atg ttc gac atg gtt ggt 1075 Ala Asp Ser Ser Glu Glu Ala Lys Asp Val Met Phe Asp Met Val Gly 310 315 320 325 cta tct gac tgg act gct gat acc gca cag gat gaa atc act cgt tac 1123 Leu Ser Asp Trp Thr Ala Asp Thr Ala Gln Asp Glu Ile Thr Arg Tyr                 330 335 340 ggc gag atc ctg aag aag ttc tcc aac taatttccct gtttccaata 1170 Gly Glu Ile Leu Lys Lys Phe Ser Asn             345 350 ctc 1173 <210> 390 <211> 350 <212> PRT <213> Corynebacterium glutamicum <400> 390 Met Phe Lys Leu Ser Lys Pro Ser Lys Ser Met Arg Val Ala Val Ser   1 5 10 15 Thr Leu Ala Ile Ser Thr Leu Ala Leu Val Gly Cys Ser Ser Ser Asp              20 25 30 Glu Ser Ser Ser Ser Ser Ser Ala Ser Ser Ser Ser Asp Ala Ala Ser          35 40 45 Gln Trp Pro Glu Ser Ile Thr Leu Ser Leu Val Pro Ser Thr Glu Gly      50 55 60 Glu Asp Leu Ala Glu Ala Leu Ala Pro Leu Thr Asp Tyr Leu Ser Glu  65 70 75 80 Asn Leu Gly Ile Glu Val Asn Gly Val Val Ala Ser Asp Tyr Ala Ala                  85 90 95 Thr Val Glu Ala Leu Gly Ala Asp Gln Ala Gln Val Ile Ile Thr Asp             100 105 110 Ala Gly Ser Leu Tyr Asn Ala Ile Glu Gln Tyr Asp Ala Gln Leu Ile         115 120 125 Leu Arg Asp Val Arg Phe Gly Ala Thr Ser Tyr Ser Ala Val Ala Tyr     130 135 140 Thr Asn Asn Pro Asp Lys Tyr Cys Asp Asp Ala Pro Val Ala Ala Ser 145 150 155 160 Tyr Ala Ala Ser Asp Val Asp Met Leu Tyr Cys Asn Gly Ile Glu Thr                 165 170 175 Glu Gly Gln Ala Ala Thr Gly Glu Gly Pro Ala Ala Leu Asp Ala Leu             180 185 190 Glu Lys Ile Glu Ser Gly Asp Lys Val Ala Leu Gln Ala Ala Thr Ser         195 200 205 Pro Ala Gly Tyr Gln Tyr Pro Ile Val Ala Met Gln Asp Leu Gly Met     210 215 220 Asp Thr Asp Ser Ala Phe Val Gln Val Pro Val Glu Gly Asn Asn Asn 225 230 235 240 Ala Val Leu Ser Val Leu Asn Gly Asp Ala Glu Val Ser Phe Gly Phe                 245 250 255 Trp Asp Ala Arg Ser Thr Val Leu Ser Glu Ala Pro Asn Ala Ala Glu             260 265 270 Asp Val Val Ala Phe Ala Tyr Thr Glu Met Ile Pro Asn Gly Gly Val         275 280 285 Ala Ala Ser Lys Ser Leu Pro Ser Asp Leu Val Glu Lys Leu Thr Glu     290 295 300 Leu Met Asp Asp Tyr Ala Asp Ser Ser Glu Glu Ala Lys Asp Val Met 305 310 315 320 Phe Asp Met Val Gly Leu Ser Asp Trp Thr Ala Asp Thr Ala Gln Asp                 325 330 335 Glu Ile Thr Arg Tyr Gly Glu Ile Leu Lys Lys Phe Ser Asn             340 345 350 <210> 391 <211> 903 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (880) <223> RXN03080 <400> 391 cttgcaaaca ggcgtggtgg tggcgttcat tggctcacca attttccttt atttactgct 60 cagcatgcgc aagcgacgcg gattggggct gtaaaaactc atg cct caa tta gtt 115                                             Met pro gln leu val                                               1 5 gaa att cgt gat ctc aac gtt gaa ttc ccc tct cgc cat gca gtg aaa 163 Glu Ile Arg Asp Leu Asn Val Glu Phe Pro Ser Arg His Ala Val Lys                  10 15 20 aac gtg tct ttt tct gca cct gct gga aaa gtc acc gca ctg att ggc 211 Asn Val Ser Phe Ser Ala Pro Ala Gly Lys Val Thr Ala Leu Ile Gly              25 30 35 cca aat ggt gct ggt aaa agt act gcc ctt tcg gcg att gca gga ttg 259 Pro Asn Gly Ala Gly Lys Ser Thr Ala Leu Ser Ala Ile Ala Gly Leu          40 45 50 gtt gaa tcc acc ggc gag gta atg gtt ggt ggg agt ggg gtt gcg tcg 307 Val Glu Ser Thr Gly Glu Val Met Val Gly Gly Ser Gly Val Ala Ser      55 60 65 aaa agc gct aaa gcc cga gcc cgc ctg ctc tca ctc gtg ccg caa aac 355 Lys Ser Ala Lys Ala Arg Ala Arg Leu Leu Ser Leu Val Pro Gln Asn  70 75 80 85 acc gag ttg cgc att ggt ttt agt gca cgc gac gtt gtc gcg atg ggc 403 Thr Glu Leu Arg Ile Gly Phe Ser Ala Arg Asp Val Val Ala Met Gly                  90 95 100 cgc tac ccg cat cgt ggc cgc ttc gcc gtg gag acc gac gca gat cga 451 Arg Tyr Pro His Arg Gly Arg Phe Ala Val Glu Thr Asp Ala Asp Arg             105 110 115 cgc gcc acc gat gac gcc ctg cgc gcc atc aac gcg ctc gac atc gcc 499 Arg Ala Thr Asp Asp Ala Leu Arg Ala Ile Asn Ala Leu Asp Ile Ala         120 125 130 gag cag ccc gtc aac gaa tta tcg ggc ggc cag cag cag cg ctc atc cac 547 Glu Gln Pro Val Asn Glu Leu Ser Gly Gly Gln Gln Gln Leu Ile His     135 140 145 atc ggc cga gcg ctc gcc caa gac acc gcc gtc gtg ctt ctc gac gag 595 Ile Gly Arg Ala Leu Ala Gln Asp Thr Ala Val Val Leu Leu Asp Glu 150 155 160 165 ccc gtc tcc gcc ctt gat cta cgg cac caa gtt gaa gtc ctt caa ctc 643 Pro Val Ser Ala Leu Asp Leu Arg His Gln Val Glu Val Leu Gln Leu                 170 175 180 ctg cgc gcc cga gct aat tcc ggc acc acc gtg atc gtc gtc ctt cac 691 Leu Arg Ala Arg Ala Asn Ser Gly Thr Thr Val Ile Val Val Leu His             185 190 195 gat ctc aac cac gtt gcc cgt tgg tgc gac cat gca gtg ttg atg gcc 739 Asp Leu Asn His Val Ala Arg Trp Cys Asp His Ala Val Leu Met Ala         200 205 210 gac ggc gaa gtt gtc tcc caa ggt gac atc cgc gag gtg ctc gaa cct 787 Asp Gly Glu Val Val Ser Gln Gly Asp Ile Arg Glu Val Leu Glu Pro     215 220 225 gcc aca ctg tcc acc gtg tac gga ctg ccc att gcg gtg cgc gat gat 835 Ala Thr Leu Ser Thr Val Tyr Gly Leu Pro Ile Ala Val Arg Asp Asp 230 235 240 245 ccc gaa acc agc tca ctt cgc gtg atc ccg cat cca aat ccc ttt 880 Pro Glu Thr Ser Ser Leu Arg Val Ile Pro His Pro Asn Pro Phe                 250 255 260 tgattgaaag tttgacttaa aaa 903 <210> 392 <211> 260 <212> PRT <213> Corynebacterium glutamicum <400> 392 Met Pro Gln Leu Val Glu Ile Arg Asp Leu Asn Val Glu Phe Pro Ser   1 5 10 15 Arg His Ala Val Lys Asn Val Ser Phe Ser Ala Pro Ala Gly Lys Val              20 25 30 Thr Ala Leu Ile Gly Pro Asn Gly Ala Gly Lys Ser Thr Ala Leu Ser          35 40 45 Ala Ile Ala Gly Leu Val Glu Ser Thr Gly Glu Val Met Val Gly Gly      50 55 60 Ser Gly Val Ala Ser Lys Ser Ala Lys Ala Arg Ala Arg Leu Leu Ser  65 70 75 80 Leu Val Pro Gln Asn Thr Glu Leu Arg Ile Gly Phe Ser Ala Arg Asp                  85 90 95 Val Val Ala Met Gly Arg Tyr Pro His Arg Gly Arg Phe Ala Val Glu             100 105 110 Thr Asp Ala Asp Arg Arg Ala Thr Asp Asp Ala Leu Arg Ala Ile Asn         115 120 125 Ala Leu Asp Ile Ala Glu Gln Pro Val Asn Glu Leu Ser Gly Gly Gln     130 135 140 Gln Gln Leu Ile His Ile Gly Arg Ala Leu Ala Gln Asp Thr Ala Val 145 150 155 160 Val Leu Leu Asp Glu Pro Val Ser Ala Leu Asp Leu Arg His Gln Val                 165 170 175 Glu Val Leu Gln Leu Leu Arg Ala Arg Ala Asn Ser Gly Thr Thr Val             180 185 190 Ile Val Val Leu His Asp Leu Asn His Val Ala Arg Trp Cys Asp His         195 200 205 Ala Val Leu Met Ala Asp Gly Glu Val Val Ser Gln Gly Asp Ile Arg     210 215 220 Glu Val Leu Glu Pro Ala Thr Leu Ser Thr Val Tyr Gly Leu Pro Ile 225 230 235 240 Ala Val Arg Asp Asp Pro Glu Thr Ser Ser Leu Arg Val Ile Pro His                 245 250 255 Pro Asn Pro Phe             260 <210> 393 <211> 582 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (559) <223> RXN03081 <400> 393 acggactgcc cattgcggtg cgcgatgatc ccgaaaccag ctcacttcgc gtgatcccgc 60 atccaaatcc cttttgattg aaagtttgac ttaaaaaccc atg aaa aaa tca ctc 115                                             Met Lys Lys Ser Leu                                               1 5 atc gcc att gtt gcc agt gcg ctc gtg tta agc ggc tgc acc tct gat 163 Ile Ala Ile Val Ala Ser Ala Leu Val Leu Ser Gly Cys Thr Ser Asp                  10 15 20 tct tct gac tct tcc ggc act tcc gga act gtg gaa acc act tcg att 211 Ser Ser Asp Ser Ser Gly Thr Ser Gly Thr Val Glu Thr Thr Ser Ile              25 30 35 aca acc agc gtt gcc gca gct gac ggc gca ttc cca cgc acc gtc aca 259 Thr Thr Ser Val Ala Ala Ala Asp Gly Ala Phe Pro Arg Thr Val Thr          40 45 50 ctc gac gat tcc tcc atc acc tta gaa tcc aaa cca gag cgc atc gcc 307 Leu Asp Asp Ser Ser Ile Thr Leu Glu Ser Lys Pro Glu Arg Ile Ala      55 60 65 gta ctc acc cca gag gca gca tcc ttg gtt ctc ccc atc aca ggc gcc 355 Val Leu Thr Pro Glu Ala Ala Ser Leu Val Leu Pro Ile Thr Gly Ala  70 75 80 85 gac cgc gtc gtg atg acc gcc gaa atg gac acc gct gac gaa gaa acc 403 Asp Arg Val Val Met Thr Ala Glu Met Asp Thr Ala Asp Glu Glu Thr                  90 95 100 gca gct ctg gcc tcc caa gtg gaa tac caa gtc aaa aac ggt ggc agg 451 Ala Ala Leu Ala Ser Gln Val Glu Tyr Gln Val Lys Asn Gly Gly Arg             105 110 115 ctc gac ccc gaa caa gtt gtc gcc ggc gac cca gat ttg gtg atc gtc 499 Leu Asp Pro Glu Gln Val Val Ala Gly Asp Pro Asp Leu Val Ile Val         120 125 130 agt gcg cgt ttc gat acc gaa caa ggc acc atc gac att ttg gaa ggc 547 Ser Ala Arg Phe Asp Thr Glu Gln Gly Thr Ile Asp Ile Leu Glu Gly     135 140 145 ctc aac gtc ccg tagttaactt cgattcagac gct 582 Leu Asn Val Pro 150 <210> 394 <211> 153 <212> PRT <213> Corynebacterium glutamicum <400> 394 Met Lys Lys Ser Leu Ile Ala Ile Val Ala Ser Ala Leu Val Leu Ser   1 5 10 15 Gly Cys Thr Ser Asp Ser Ser Asp Ser Ser Gly Thr Ser Gly Thr Val              20 25 30 Glu Thr Thr Ser Ile Thr Thr Ser Val Ala Ala Ala Asp Gly Ala Phe          35 40 45 Pro Arg Thr Val Thr Leu Asp Asp Ser Ser Ile Thr Leu Glu Ser Lys      50 55 60 Pro Glu Arg Ile Ala Val Leu Thr Pro Glu Ala Ala Ser Leu Val Leu  65 70 75 80 Pro Ile Thr Gly Ala Asp Arg Val Val Met Thr Ala Glu Met Asp Thr                  85 90 95 Ala Asp Glu Glu Thr Ala Ala Leu Ala Ser Gln Val Glu Tyr Gln Val             100 105 110 Lys Asn Gly Gly Arg Leu Asp Pro Glu Gln Val Val Ala Gly Asp Pro         115 120 125 Asp Leu Val Ile Val Ser Ala Arg Phe Asp Thr Glu Gln Gly Thr Ile     130 135 140 Asp Ile Leu Glu Gly Leu Asn Val Pro 145 150 <210> 395 <211> 444 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (421) <223> RXN03082 <400> 395 cagaagcaat cgcagaaatc gatgcaaacc gcattcgaca ttcgacaagc ctgccacctc 60 ccccactgtg ctcactttga tgcaacgcgg accacgccaa atg gtc atg cca gaa 115                                             Met Val Met Pro Glu                                               1 5 tct gcc atg ctc acc ggc ctg atc cgc gaa gcc ggc ggc act cca gtg 163 Ser Ala Met Leu Thr Gly Leu Ile Arg Glu Ala Gly Gly Thr Pro Val                  10 15 20 gta gat tct ctc ggc gcg gta ggc acc atc act gca gac cca gaa caa 211 Val Asp Ser Leu Gly Ala Val Gly Thr Ile Thr Ala Asp Pro Glu Gln              25 30 35 gtt gtt gcg atg gca cct gag atc atc atc att cag gac ttc caa ggt 259 Val Val Ala Met Ala Pro Glu Ile Ile Ile Ile Gln Asp Phe Gln Gly          40 45 50 aaa ggc cga gag aac ttc gct aat ttc ctc tcc aac cca gcg cta gcc 307 Lys Gly Arg Glu Asn Phe Ala Asn Phe Leu Ser Asn Pro Ala Leu Ala      55 60 65 aac gtt ccc gcc att gaa aac gac aag att ttc tac gcc gac act gtc 355 Asn Val Pro Ala Ile Glu Asn Asp Lys Ile Phe Tyr Ala Asp Thr Val  70 75 80 85 acc act gga gtt act gca ggt acc gat atc acc act ggt ctg cag caa 403 Thr Thr Gly Val Thr Ala Gly Thr Asp Ile Thr Thr Gly Leu Gln Gln                  90 95 100 gtg gca gaa atg ctg agc tagttttgag atgttgaaac tag 444 Val Ala Glu Met Leu Ser             105 <210> 396 <211> 107 <212> PRT <213> Corynebacterium glutamicum <400> 396 Met Val Met Pro Glu Ser Ala Met Leu Thr Gly Leu Ile Arg Glu Ala   1 5 10 15 Gly Gly Thr Pro Val Val Asp Ser Leu Gly Ala Val Gly Thr Ile Thr              20 25 30 Ala Asp Pro Glu Gln Val Val Ala Met Ala Pro Glu Ile Ile Ile Ile          35 40 45 Gln Asp Phe Gln Gly Lys Gly Arg Glu Asn Phe Ala Asn Phe Leu Ser      50 55 60 Asn Pro Ala Leu Ala Asn Val Pro Ala Ile Glu Asn Asp Lys Ile Phe  65 70 75 80 Tyr Ala Asp Thr Val Thr Thr Gly Val Thr Ala Gly Thr Asp Ile Thr                  85 90 95 Thr Gly Leu Gln Gln Val Ala Glu Met Leu Ser             100 105 <210> 397 <211> 1479 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1456) <223> RXA02261 <400> 397 gaaatctata gaacgatagg taaaaactgg actaggttta tctatagcgg aatagaaaat 60 actccgctcg acagcatcac ttagctgaaa ggcctttaac atg gac ccc tca gat 115                                             Met Asp Pro Ser Asp                                               1 5 cta gcc tgg att ctc gca gct ttt gcg ttg gta agc ctg atg ttc ccc 163 Leu Ala Trp Ile Leu Ala Ala Phe Ala Leu Val Ser Leu Met Phe Pro                  10 15 20 gga ttg tcc ctg ctc tac ggc ggc atg ctg ggt ggg caa cac gtt ctt 211 Gly Leu Ser Leu Leu Tyr Gly Gly Met Leu Gly Gly Gln His Val Leu              25 30 35 aac acg ttc atg atg gtt atg agc tca ctt gga atc atc agc ctt gtg 259 Asn Thr Phe Met Met Val Met Ser Ser Leu Gly Ile Ile Ser Leu Val          40 45 50 tac atc att tat gga cac gga ctt gtc tta gga aac tcc atc ggt ggg 307 Tyr Ile Ile Tyr Gly His Gly Leu Val Leu Gly Asn Ser Ile Gly Gly      55 60 65 tgg gga att atc gga aat ccc ctt gaa tac ttc ggc ttc cgc aac att 355 Trp Gly Ile Ile Gly Asn Pro Leu Glu Tyr Phe Gly Phe Arg Asn Ile  70 75 80 85 atg gaa gat gac ggc acc gga gac ctc atg tgg gcc ggc ttc tac att 403 Met Glu Asp Asp Gly Thr Gly Asp Leu Met Trp Ala Gly Phe Tyr Ile                  90 95 100 ctg ttc gct gca atc tca ctc gca ctt gtt tca tct ggt gca gcg ggg 451 Leu Phe Ala Ala Ile Ser Leu Ala Leu Val Ser Ser Gly Ala Ala Gly             105 110 115 cgc atg cgc ttt gga gcg tgg ctg gtc ttc ggt gtc ctg tgg ttc acc 499 Arg Met Arg Phe Gly Ala Trp Leu Val Phe Gly Val Leu Trp Phe Thr         120 125 130 ttt gtg tac gcg cca ctg gca cac tgg gtt ttc gct atc gat gat cct 547 Phe Val Tyr Ala Pro Leu Ala His Trp Val Phe Ala Ile Asp Asp Pro     135 140 145 gag tcc ggc tac gtg ggt ggc tgg atg aaa aat gtg ctt gag ttc cac 595 Glu Ser Gly Tyr Val Gly Gly Trp Met Lys Asn Val Leu Glu Phe His 150 155 160 165 gac ttt gct ggt gga acg gca gtg cac atg aat gcg ggt gcg tct gga 643 Asp Phe Ala Gly Gly Thr Ala Val His Met Asn Ala Gly Ala Ser Gly                 170 175 180 ctc gcg ctg gca ata gtg ctg gga cgc cgc cac tcc atg gct gtg cgt 691 Leu Ala Leu Ala Ile Val Leu Gly Arg Arg His Ser Met Ala Val Arg             185 190 195 cca cac aac ctt cca ctg att ttg att ggt gca gga ctg atc gtt gcg 739 Pro His Asn Leu Pro Leu Ile Leu Ile Gly Ala Gly Leu Ile Val Ala         200 205 210 ggc tgg ttc gga ttc aat ggt ggt acc gca ggt ggt gcc aac ttc ctc 787 Gly Trp Phe Gly Phe Asn Gly Gly Thr Ala Gly Gly Ala Asn Phe Leu     215 220 225 gca agc tac gtg gtc gtt acc tct ctc att gct gca gct ggc gga atg 835 Ala Ser Tyr Val Val Val Thr Ser Leu Ile Ala Ala Ala Gly Gly Met 230 235 240 245 atg ggc ttc atg ctc gtt gaa cgt gtg ttc agc gga aaa ccc act ttc 883 Met Gly Phe Met Leu Val Glu Arg Val Phe Ser Gly Lys Pro Thr Phe                 250 255 260 ttt ggc tcg gca acc ggc aca atc gca ggc ctt gtg gct atc acc ccg 931 Phe Gly Ser Ala Thr Gly Thr Ile Ala Gly Leu Val Ala Ile Thr Pro             265 270 275 gcc gcg gat gca gtg agc ccg ctc gga gca ttc gcc gtc gga gcg ctc 979 Ala Ala Asp Ala Val Ser Pro Leu Gly Ala Phe Ala Val Gly Ala Leu         280 285 290 ggc gca gtt gtc tcc ttc tgg gca att agc tgg aag aag gga cac cga 1027 Gly Ala Val Val Ser Phe Trp Ala Ile Ser Trp Lys Lys Gly His Arg     295 300 305 gtc gat gat tcc ttc gat gtg ttc gca gtc cac gga atg gcc ggc att 1075 Val Asp Asp Ser Phe Asp Val Phe Ala Val His Gly Met Ala Gly Ile 310 315 320 325 gca ggt gca ctg ttt gtc atg ctc ttt ggc gat cca cta gca cca gcg 1123 Ala Gly Ala Leu Phe Val Met Leu Phe Gly Asp Pro Leu Ala Pro Ala                 330 335 340 gga gtt tcc gga gtc ttc ttc ggt ggc gaa ctc tcc ctg ctg tgg agg 1171 Gly Val Ser Gly Val Phe Phe Gly Gly Glu Leu Ser Leu Leu Trp Arg             345 350 355 gaa cca ctg gcc atc atc gtg acc ctt aca tac gca ttc ggc gtg acc 1219 Glu Pro Leu Ala Ile Ile Val Thr Leu Thr Tyr Ala Phe Gly Val Thr         360 365 370 tgg ttg att gcc acg atc ttg aac aag ttc atg act ctg cgc atc acc 1267 Trp Leu Ile Ala Thr Ile Leu Asn Lys Phe Met Thr Leu Arg Ile Thr     375 380 385 tcc gaa gcc gaa tat gaa ggc att gac cgc gca gaa cac gca gaa tct 1315 Ser Glu Ala Glu Tyr Glu Gly Ile Asp Arg Ala Glu His Ala Glu Ser 390 395 400 405 gcc tac cac ctc aat tcc aac gga att ggg atg gca acc cgc acc aat 1363 Ala Tyr His Leu Asn Ser Asn Gly Ile Gly Met Ala Thr Arg Thr Asn                 410 415 420 ttc gga cct gaa atc ccc gag gaa acc gtg ccc gac gcc gtg cag gtg 1411 Phe Gly Pro Glu Ile Pro Glu Glu Thr Val Pro Asp Ala Val Gln Val             425 430 435 ggc gtc gat aag caa aaa atc gct gat act cga aag gcc tca aaa 1456 Gly Val Asp Lys Gln Lys Ile Ala Asp Thr Arg Lys Ala Ser Lys         440 445 450 tgaccgcaac ctacaccact gaa 1479 <210> 398 <211> 452 <212> PRT <213> Corynebacterium glutamicum <400> 398 Met Asp Pro Ser Asp Leu Ala Trp Ile Leu Ala Ala Phe Ala Leu Val   1 5 10 15 Ser Leu Met Phe Pro Gly Leu Ser Leu Leu Tyr Gly Gly Met Leu Gly              20 25 30 Gly Gln His Val Leu Asn Thr Phe Met Met Val Met Ser Ser Leu Gly          35 40 45 Ile Ile Ser Leu Val Tyr Ile Ile Tyr Gly His Gly Leu Val Leu Gly      50 55 60 Asn Ser Ile Gly Gly Trp Gly Ile Ile Gly Asn Pro Leu Glu Tyr Phe  65 70 75 80 Gly Phe Arg Asn Ile Met Glu Asp Asp Gly Thr Gly Asp Leu Met Trp                  85 90 95 Ala Gly Phe Tyr Ile Leu Phe Ala Ala Ile Ser Leu Ala Leu Val Ser             100 105 110 Ser Gly Ala Ala Gly Arg Met Arg Phe Gly Ala Trp Leu Val Phe Gly         115 120 125 Val Leu Trp Phe Thr Phe Val Tyr Ala Pro Leu Ala His Trp Val Phe     130 135 140 Ala Ile Asp Asp Pro Glu Ser Gly Tyr Val Gly Gly Trp Met Lys Asn 145 150 155 160 Val Leu Glu Phe His Asp Phe Ala Gly Gly Thr Ala Val His Met Asn                 165 170 175 Ala Gly Ala Ser Gly Leu Ala Leu Ala Ile Val Leu Gly Arg Arg His             180 185 190 Ser Met Ala Val Arg Pro His Asn Leu Pro Leu Ile Leu Ile Gly Ala         195 200 205 Gly Leu Ile Val Ala Gly Trp Phe Gly Phe Asn Gly Gly Thr Ala Gly     210 215 220 Gly Ala Asn Phe Leu Ala Ser Tyr Val Val Val Thr Ser Leu Ile Ala 225 230 235 240 Ala Ala Gly Gly Met Met Gly Phe Met Leu Val Glu Arg Val Phe Ser                 245 250 255 Gly Lys Pro Thr Phe Phe Gly Ser Ala Thr Gly Thr Ile Ala Gly Leu             260 265 270 Val Ala Ile Thr Pro Ala Ala Asp Ala Val Ser Pro Leu Gly Ala Phe         275 280 285 Ala Val Gly Ala Leu Gly Ala Val Val Ser Phe Trp Ala Ile Ser Trp     290 295 300 Lys Lys Gly His Arg Val Asp Asp Ser Phe Asp Val Phe Ala Val His 305 310 315 320 Gly Met Ala Gly Ile Ala Gly Ala Leu Phe Val Met Leu Phe Gly Asp                 325 330 335 Pro Leu Ala Pro Ala Gly Val Ser Gly Val Phe Phe Gly Gly Glu Leu             340 345 350 Ser Leu Leu Trp Arg Glu Pro Leu Ala Ile Ile Val Thr Leu Thr Tyr         355 360 365 Ala Phe Gly Val Thr Trp Leu Ile Ala Thr Ile Leu Asn Lys Phe Met     370 375 380 Thr Leu Arg Ile Thr Ser Glu Ala Glu Tyr Glu Gly Ile Asp Arg Ala 385 390 395 400 Glu His Ala Glu Ser Ala Tyr His Leu Asn Ser Asn Gly Ile Gly Met                 405 410 415 Ala Thr Arg Thr Asn Phe Gly Pro Glu Ile Pro Glu Glu Thr Val Pro             420 425 430 Asp Ala Val Gln Val Gly Val Asp Lys Gln Lys Ile Ala Asp Thr Arg         435 440 445 Lys Ala Ser Lys     450 <210> 399 <211> 1111 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (1111) <223> RXA02020 <400> 399 ttggtcaatc aagcgtgaat ccggcttcca tgagccagtt gcccgcctca aagcttgacc 60 cattttcata accagtgcca tgtgggttta cggttgatac atg gct aaa tct aat 115                                             Met ala lys ser asn                                               1 5 gaa ggg ctg gga acc gga ctt cgg acc cgc cac ctc aca atg atg gga 163 Glu Gly Leu Gly Thr Gly Leu Arg Thr Arg His Leu Thr Met Met Gly                  10 15 20 ctc ggc tcc gca att ggt gcc gga ctg ttc ctc ggc acc ggc gtt ggt 211 Leu Gly Ser Ala Ile Gly Ala Gly Leu Phe Leu Gly Thr Gly Val Gly              25 30 35 atc cgc gca gcc ggc ccc gca gtg ctc ctg gcg tac atc atc gcc gga 259 Ile Arg Ala Ala Gly Pro Ala Val Leu Leu Ala Tyr Ile Ile Ala Gly          40 45 50 gcc atc gtt gtg ctt gtt atg caa atg ctc ggc gag atg gct gct gcc 307 Ala Ile Val Val Leu Val Met Gln Met Leu Gly Glu Met Ala Ala Ala      55 60 65 cgt ccc gcc tcc gga tcg ttt tca cgt tac ggc gag gat gct ttc ggc 355 Arg Pro Ala Ser Gly Ser Phe Ser Arg Tyr Gly Glu Asp Ala Phe Gly  70 75 80 85 cac tgg gct ggt ttc tcc ctc ggt tgg ttg tac tgg ttc atg ctg att 403 His Trp Ala Gly Phe Ser Leu Gly Trp Leu Tyr Trp Phe Met Leu Ile                  90 95 100 atg gtg atg ggc gcc gaa atg act ggc gct gct gcc atc atg ggt gca 451 Met Val Met Gly Ala Glu Met Thr Gly Ala Ala Ala Ile Met Gly Ala             105 110 115 tgg ttc ggc gtc gaa ccg tgg att cct tcg ctt gtc tgc gtg gtc ttc 499 Trp Phe Gly Val Glu Pro Trp Ile Pro Ser Leu Val Cys Val Val Phe         120 125 130 ttc gct gtg gtg aac ctc gtc gcg gtt cgc ggt ttc ggt gaa ttc gag 547 Phe Ala Val Val Asn Leu Val Ala Val Arg Gly Phe Gly Glu Phe Glu     135 140 145 tac tgg ttc gca ttc att aag gtc gcg gtg atc atc gct ttc ctc atc 595 Tyr Trp Phe Ala Phe Ile Lys Val Ala Val Ile Ila Ala Phe Leu Ile 150 155 160 165 att ggt att gct ctt att ttc gga tgg ctt ccc gga tcc acc ttt gtt 643 Ile Gly Ile Ala Leu Ile Phe Gly Trp Leu Pro Gly Ser Thr Phe Val                 170 175 180 gga acc tca aac ttc atc ggt gat cac gga ttc atg ccc aat ggt att 691 Gly Thr Ser Asn Phe Ile Gly Asp His Gly Phe Met Pro Asn Gly Ile             185 190 195 tct ggt gtt gct gct ggt ttg ctc gcg gtg gct ttt gcc ttt ggt ggc 739 Ser Gly Val Ala Ala Gly Leu Leu Ala Val Ala Phe Ala Phe Gly Gly         200 205 210 att gaa att gtc acc att gca gct gca gag tcc gat aag cca cgt gaa 787 Ile Glu Ile Val Thr Ile Ala Ala Ala Glu Ser Asp Lys Pro Arg Glu     215 220 225 gct att tcc ctg gcg gtg cgt gcc gtg att tgg cgt att tca gtc ttt 835 Ala Ile Ser Leu Ala Val Arg Ala Val Ile Trp Arg Ile Ser Val Phe 230 235 240 245 tac ttg ggc tct gtt ttg gtc atc act ttc ctc atg cct tat gag tcg 883 Tyr Leu Gly Ser Val Leu Val Ile Thr Phe Leu Met Pro Tyr Glu Ser                 250 255 260 atc aat ggt gcc gac acc gct gcg gaa tcc ccc ttc acc caa atc ctg 931 Ile Asn Gly Ala Asp Thr Ala Ala Glu Ser Pro Phe Thr Gln Ile Leu             265 270 275 gcg atg gca aac atc cct ggc acg gtt ggt ttc atg gaa gcg atc atc 979 Ala Met Ala Asn Ile Pro Gly Thr Val Gly Phe Met Glu Ala Ile Ile         280 285 290 gtt cta gca ctg ctt tcc gct ttc aac gcc caa atc tat gcc act tct 1027 Val Leu Ala Leu Leu Ser Ala Phe Asn Ala Gln Ile Tyr Ala Thr Ser     295 300 305 cgt ttg gta ttt tcc atg gcg aat cga caa gac gct ccg cga gtt ttc 1075 Arg Leu Val Phe Ser Met Ala Asn Arg Gln Asp Ala Pro Arg Val Phe 310 315 320 325 agt aag ctc agc acc agc cac gtc ccc acc aat gcg 1111 Ser Lys Leu Ser Thr Ser His Val Pro Thr Asn Ala                 330 335 <210> 400 <211> 337 <212> PRT <213> Corynebacterium glutamicum <400> 400 Met Ala Lys Ser Asn Glu Gly Leu Gly Thr Gly Leu Arg Thr Arg His   1 5 10 15 Leu Thr Met Met Gly Leu Gly Ser Ala Ile Gly Ala Gly Leu Phe Leu              20 25 30 Gly Thr Gly Val Gly Ile Arg Ala Ala Gly Pro Ala Val Leu Leu Ala          35 40 45 Tyr Ile Ile Ala Gly Ala Ile Val Val Leu Val Met Gln Met Leu Gly      50 55 60 Glu Met Ala Ala Ala Arg Pro Ala Ser Gly Ser Phe Ser Arg Tyr Gly  65 70 75 80 Glu Asp Ala Phe Gly His Trp Ala Gly Phe Ser Leu Gly Trp Leu Tyr                  85 90 95 Trp Phe Met Leu Ile Met Val Met Gly Ala Glu Met Thr Gly Ala Ala             100 105 110 Ala Ile Met Gly Ala Trp Phe Gly Val Glu Pro Trp Ile Pro Ser Leu         115 120 125 Val Cys Val Val Phe Phe Ala Val Val Asn Leu Val Ala Val Arg Gly     130 135 140 Phe Gly Glu Phe Glu Tyr Trp Phe Ala Phe Ile Lys Val Ala Val Ile 145 150 155 160 Ile Ala Phe Leu Ile Ile Gly Ile Ala Leu Ile Phe Gly Trp Leu Pro                 165 170 175 Gly Ser Thr Phe Val Gly Thr Ser Asn Phe Ile Gly Asp His Gly Phe             180 185 190 Met Pro Asn Gly Ile Ser Gly Val Ala Ala Gly Leu Leu Ala Val Ala         195 200 205 Phe Ala Phe Gly Gly Ile Glu Ile Val Thr Ile Ala Ala Ala Glu Ser     210 215 220 Asp Lys Pro Arg Glu Ala Ile Ser Leu Ala Val Arg Ala Val Ile Trp 225 230 235 240 Arg Ile Ser Val Phe Tyr Leu Gly Ser Val Leu Val Ile Thr Phe Leu                 245 250 255 Met Pro Tyr Glu Ser Ile Asn Gly Ala Asp Thr Ala Ala Glu Ser Pro             260 265 270 Phe Thr Gln Ile Leu Ala Met Ala Asn Ile Pro Gly Thr Val Gly Phe         275 280 285 Met Glu Ala Ile Ile Val Leu Ala Leu Leu Ser Ala Phe Asn Ala Gln     290 295 300 Ile Tyr Ala Thr Ser Arg Leu Val Phe Ser Met Ala Asn Arg Gln Asp 305 310 315 320 Ala Pro Arg Val Phe Ser Lys Leu Ser Thr Ser His Val Pro Thr Asn                 325 330 335 Ala <210> 401 <211> 784 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (784) <223> RXA00281 <400> 401 ggttgactct ttggctttga tgccagcatt cgccaaagcg tggccctctt taagaaagct 60 actgaacaca acagagtagg tttatgcgac actggtgcgc atg atc aac gtt gaa 115                                             Met Ile Asn Val Glu                                               1 5 ggc ctc acc aaa caa tat ggt cag gtc cgc gca gtc gat gat ctg agc 163 Gly Leu Thr Lys Gln Tyr Gly Gln Val Arg Ala Val Asp Asp Leu Ser                  10 15 20 ttc gaa gta aaa ccc gga ata gtc acc gga ttt ctc ggc ccc aac ggc 211 Phe Glu Val Lys Pro Gly Ile Val Thr Gly Phe Leu Gly Pro Asn Gly              25 30 35 gcc gga aaa tcc acc acg atg cgg ctg atc ctt ggc tta gat aat cca 259 Ala Gly Lys Ser Thr Thr Met Arg Leu Ile Leu Gly Leu Asp Asn Pro          40 45 50 act gca ggg cat gcc acg atc gaa gga caa ccc tac cga tcg ctc aaa 307 Thr Ala Gly His Ala Thr Ile Glu Gly Gln Pro Tyr Arg Ser Leu Lys      55 60 65 aat ccc ctg acc aaa gtg gga gca ctg ctt gat gcc aaa gca aca cac 355 Asn Pro Leu Thr Lys Val Gly Ala Leu Leu Asp Ala Lys Ala Thr His  70 75 80 85 cca aat aga aca gca gaa aac cac ctc aag tgg atc gcc cgt gca aat 403 Pro Asn Arg Thr Ala Glu Asn His Leu Lys Trp Ile Ala Arg Ala Asn                  90 95 100 ggg ctg tcc acc aaa aga gtc gat gaa gtt ctc acc ctc gtg gga ctg 451 Gly Leu Ser Thr Lys Arg Val Asp Glu Val Leu Thr Leu Val Gly Leu             105 110 115 act ggt gtt ggg tca aag aag acc ggt ggg ttt tca cta ggc atg ggc 499 Thr Gly Val Gly Ser Lys Lys Thr Gly Gly Phe Ser Leu Gly Met Gly         120 125 130 caa cgt cta gga ctt gct gca gca ttg ctc ggc gat ccg gaa tac tta 547 Gln Arg Leu Gly Leu Ala Ala Ala Leu Leu Gly Asp Pro Glu Tyr Leu     135 140 145 att ctc gac gaa ccc gtc aac ggc ctt gac cca gaa ggc att cac tgg 595 Ile Leu Asp Glu Pro Val Asn Gly Leu Asp Pro Glu Gly Ile His Trp 150 155 160 165 gtg cgc acc ttg ttg caa aac atc gcc aag cag ggc aga acc gtg ctc 643 Val Arg Thr Leu Leu Gln Asn Ile Ala Lys Gln Gly Arg Thr Val Leu                 170 175 180 gtg agt tcc cac ctg ctg tcc gag atg gcg caa act gcg gaa cat ttg 691 Val Ser Ser His Leu Leu Ser Glu Met Ala Gln Thr Ala Glu His Leu             185 190 195 atc gtg att ggg cgt ggc aag ctg gtc gcc gat atg ccc atg cat gag 739 Ile Val Ile Gly Arg Gly Lys Leu Val Ala Asp Met Pro Met His Glu         200 205 210 ttt gtg cgc tcc cat tcc gct tcc aca gtt gtg gtg cgg gca gca 784 Phe Val Arg Ser His Ser Ala Ser Thr Val Val Val Arg Ala Ala     215 220 225 <210> 402 <211> 228 <212> PRT <213> Corynebacterium glutamicum <400> 402 Met Ile Asn Val Glu Gly Leu Thr Lys Gln Tyr Gly Gln Val Arg Ala   1 5 10 15 Val Asp Asp Leu Ser Phe Glu Val Lys Pro Gly Ile Val Thr Gly Phe              20 25 30 Leu Gly Pro Asn Gly Ala Gly Lys Ser Thr Thr Met Arg Leu Ile Leu          35 40 45 Gly Leu Asp Asn Pro Thr Ala Gly His Ala Thr Ile Glu Gly Gln Pro      50 55 60 Tyr Arg Ser Leu Lys Asn Pro Leu Thr Lys Val Gly Ala Leu Leu Asp  65 70 75 80 Ala Lys Ala Thr His Pro Asn Arg Thr Ala Glu Asn His Leu Lys Trp                  85 90 95 Ile Ala Arg Ala Asn Gly Leu Ser Thr Lys Arg Val Asp Glu Val Leu             100 105 110 Thr Leu Val Gly Leu Thr Gly Val Gly Ser Lys Lys Thr Gly Gly Phe         115 120 125 Ser Leu Gly Met Gly Gln Arg Leu Gly Leu Ala Ala Ala Leu Leu Gly     130 135 140 Asp Pro Glu Tyr Leu Ile Leu Asp Glu Pro Val Asn Gly Leu Asp Pro 145 150 155 160 Glu Gly Ile His Trp Val Arg Thr Leu Leu Gln Asn Ile Ala Lys Gln                 165 170 175 Gly Arg Thr Val Leu Val Ser Ser His Leu Leu Ser Glu Met Ala Gln             180 185 190 Thr Ala Glu His Leu Ile Val Ile Gly Arg Gly Lys Leu Val Ala Asp         195 200 205 Met Pro Met His Glu Phe Val Arg Ser His Ser Ala Ser Thr Val Val     210 215 220 Val Arg Ala Ala 225 <210> 403 <211> 852 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (852) <223> RXN00570 <400> 403 acg aga cct cgg ccc caa gaa att ggc aac ggg ctt gtc gca ctg att 48 Thr Arg Pro Arg Pro Gln Glu Ile Gly Asn Gly Leu Val Ala Leu Ile   1 5 10 15 ttc tcc gca tcc gga ccc atc gca gtg atc ctg gct gct gct gca gcg 96 Phe Ser Ala Ser Gly Pro Ile Ala Val Ile Leu Ala Ala Ala Ala Ala              20 25 30 gga aac ctt tcg cct gat caa aca tct tca tgg atc ttc gga gca ttt 144 Gly Asn Leu Ser Pro Asp Gln Thr Ser Ser Trp Ile Phe Gly Ala Phe          35 40 45 tta ggc aac gga ctg ctc acg ctg tgg ctt acc tat atg tac cgc agc 192 Leu Gly Asn Gly Leu Leu Thr Leu Trp Leu Thr Tyr Met Tyr Arg Ser      50 55 60 ccg cag gca tac ttc tgg acg att ccc gga acc gtc atc gtg ggc gac 240 Pro Gln Ala Tyr Phe Trp Thr Ile Pro Gly Thr Val Ile Val Gly Asp  65 70 75 80 tca ctt acc cac tta agt ttc gct gaa gtt atc ggc gca tac ctt gtt 288 Ser Leu Thr His Leu Ser Phe Ala Glu Val Ile Gly Ala Tyr Leu Val                  85 90 95 acc ggc gtt gtg gtg ttt gcg ctc gga tgg acc ggt ctc atc gga cgg 336 Thr Gly Val Val Val Phe Ala Leu Gly Trp Thr Gly Leu Ile Gly Arg             100 105 110 atc atg gcg gta ctg cca cca acc atc gtg atg gcc atg gtc gca ggc 384 Ile Met Ala Val Leu Pro Pro Thr Ile Val Met Ala Met Val Ala Gly         115 120 125 att ttc ctc cgc ttc gga ctc gac ctc atc gac gcc agc gtg acc gac 432 Ile Phe Leu Arg Phe Gly Leu Asp Leu Ile Asp Ala Ser Val Thr Asp     130 135 140 ccg ctc att gca ctt ccc atg gtc ata gtt ttt gtg gca ttg agc atg 480 Pro Leu Ile Ala Leu Pro Met Val Ile Val Phe Val Ala Leu Ser Met 145 150 155 160 agt ccc cgc ttg gca agc atc gcc cca ccc gtt gca gta gcc gca gta 528 Ser Pro Arg Leu Ala Ser Ile Ala Pro Pro Val Ala Val Ala Ala Val                 165 170 175 gtg gga acc atc gtt gcc atc gca tcc ggc aaa cta gcg tcc gga att 576 Val Gly Thr Ile Val Ala Ile Ala Ser Gly Lys Leu Ala Ser Gly Ile             180 185 190 cta gac aac gga att atc tcc cgc ccc gtc ttt acc gcc cca gaa ttt 624 Leu Asp Asn Gly Ile Ile Ser Arg Pro Val Phe Thr Ala Pro Glu Phe         195 200 205 tcc ttc gcc gcc atc atg gaa ctc gtt gtt ccc ttg gcg atc acc gta 672 Ser Phe Ala Ala Ile Met Glu Leu Val Val Pro Leu Ala Ile Thr Val     210 215 220 gtc att gtc caa aac ggc caa ggc gtc gca gtg ctt aaa gca gca ggt 720 Val Ile Val Gln Asn Gly Gln Gly Val Ala Val Leu Lys Ala Ala Gly 225 230 235 240 cac cgc ccc gga gta aac ctt gcc gcc gcg gcc tcc gga ctg tgg tcc 768 His Arg Pro Gly Val Asn Leu Ala Ala Ala Ala Ser Gly Leu Trp Ser                 245 250 255 cta ccc atg gcg ttg atc ggc aac atc acc acc tgc ctc acc ggc ccc 816 Leu Pro Met Ala Leu Ile Gly Asn Ile Thr Thr Cys Leu Thr Gly Pro             260 265 270 acc aac gcg ctg atc gtc gcc gga gca aaa tca cac 852 Thr Asn Ala Leu Ile Val Ala Gly Ala Lys Ser His         275 280 <210> 404 <211> 284 <212> PRT <213> Corynebacterium glutamicum <400> 404 Thr Arg Pro Arg Pro Gln Glu Ile Gly Asn Gly Leu Val Ala Leu Ile   1 5 10 15 Phe Ser Ala Ser Gly Pro Ile Ala Val Ile Leu Ala Ala Ala Ala Ala              20 25 30 Gly Asn Leu Ser Pro Asp Gln Thr Ser Ser Trp Ile Phe Gly Ala Phe          35 40 45 Leu Gly Asn Gly Leu Leu Thr Leu Trp Leu Thr Tyr Met Tyr Arg Ser      50 55 60 Pro Gln Ala Tyr Phe Trp Thr Ile Pro Gly Thr Val Ile Val Gly Asp  65 70 75 80 Ser Leu Thr His Leu Ser Phe Ala Glu Val Ile Gly Ala Tyr Leu Val                  85 90 95 Thr Gly Val Val Val Phe Ala Leu Gly Trp Thr Gly Leu Ile Gly Arg             100 105 110 Ile Met Ala Val Leu Pro Pro Thr Ile Val Met Ala Met Val Ala Gly         115 120 125 Ile Phe Leu Arg Phe Gly Leu Asp Leu Ile Asp Ala Ser Val Thr Asp     130 135 140 Pro Leu Ile Ala Leu Pro Met Val Ile Val Phe Val Ala Leu Ser Met 145 150 155 160 Ser Pro Arg Leu Ala Ser Ile Ala Pro Pro Val Ala Val Ala Ala Val                 165 170 175 Val Gly Thr Ile Val Ala Ile Ala Ser Gly Lys Leu Ala Ser Gly Ile             180 185 190 Leu Asp Asn Gly Ile Ile Ser Arg Pro Val Phe Thr Ala Pro Glu Phe         195 200 205 Ser Phe Ala Ala Ile Met Glu Leu Val Val Pro Leu Ala Ile Thr Val     210 215 220 Val Ile Val Gln Asn Gly Gln Gly Val Ala Val Leu Lys Ala Ala Gly 225 230 235 240 His Arg Pro Gly Val Asn Leu Ala Ala Ala Ala Ser Gly Leu Trp Ser                 245 250 255 Leu Pro Met Ala Leu Ile Gly Asn Ile Thr Thr Cys Leu Thr Gly Pro             260 265 270 Thr Asn Ala Leu Ile Val Ala Gly Ala Lys Ser His         275 280 <210> 405 <211> 498 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (498) <223> FRXA00570 <400> 405 cca acc atc gtg atg gcc atg gtc gca ggc att ttc ctc cgc ttc gga 48 Pro Thr Ile Val Met Ala Met Val Ala Gly Ile Phe Leu Arg Phe Gly   1 5 10 15 ctc gac ctc atc gac gcc agc gtg acc gac ccg ctc att gca ctt ccc 96 Leu Asp Leu Ile Asp Ala Ser Val Thr Asp Pro Leu Ile Ala Leu Pro              20 25 30 atg gtc ata gtt ttt gtg gca ttg agc atg agt ccc cgc ttg gca agc 144 Met Val Ile Val Phe Val Ala Leu Ser Met Ser Pro Arg Leu Ala Ser          35 40 45 atc gcc cca ccc gtt gca gta gcc gca gta gtg gga acc atc gtt gcc 192 Ile Ala Pro Pro Val Ala Val Ala Ala Val Val Gly Thr Ile Val Ala      50 55 60 atc gca tcc ggc aaa cta gcg tcc gga att cta gac aac gga att atc 240 Ile Ala Ser Gly Lys Leu Ala Ser Gly Ile Leu Asp Asn Gly Ile Ile  65 70 75 80 tcc cgc ccc gtc ttt acc gcc cca gaa ttt tcc ttc gcc gcc atc atg 288 Ser Arg Pro Val Phe Thr Ala Pro Glu Phe Ser Phe Ala Ala Ile Met                  85 90 95 gaa ctc gtt gtt ccc ttg gcg atc acc gta gtc att gtc caa aac ggc 336 Glu Leu Val Val Pro Leu Ala Ile Thr Val Val Ile Val Gln Asn Gly             100 105 110 caa ggc gtc gca gtg ctt aaa gca gca ggt cac cgc ccc gga gta aac 384 Gln Gly Val Ala Val Leu Lys Ala Ala Gly His Arg Pro Gly Val Asn         115 120 125 ctt gcc gcc gcg gcc tcc gga ctg tgg tcc cta ccc atg gcg ttg atc 432 Leu Ala Ala Ala Ala Ser Gly Leu Trp Ser Leu Pro Met Ala Leu Ile     130 135 140 ggc aac atc acc acc tgc ctc acc ggc ccc acc aac gcg ctg atc gtc 480 Gly Asn Ile Thr Thr Cys Leu Thr Gly Pro Thr Asn Ala Leu Ile Val 145 150 155 160 gcc gga gca aaa tca cac 498 Ala Gly Ala Lys Ser His                 165 <210> 406 <211> 166 <212> PRT <213> Corynebacterium glutamicum <400> 406 Pro Thr Ile Val Met Ala Met Val Ala Gly Ile Phe Leu Arg Phe Gly   1 5 10 15 Leu Asp Leu Ile Asp Ala Ser Val Thr Asp Pro Leu Ile Ala Leu Pro              20 25 30 Met Val Ile Val Phe Val Ala Leu Ser Met Ser Pro Arg Leu Ala Ser          35 40 45 Ile Ala Pro Pro Val Ala Val Ala Ala Val Val Gly Thr Ile Val Ala      50 55 60 Ile Ala Ser Gly Lys Leu Ala Ser Gly Ile Leu Asp Asn Gly Ile Ile  65 70 75 80 Ser Arg Pro Val Phe Thr Ala Pro Glu Phe Ser Phe Ala Ala Ile Met                  85 90 95 Glu Leu Val Val Pro Leu Ala Ile Thr Val Val Ile Val Gln Asn Gly             100 105 110 Gln Gly Val Ala Val Leu Lys Ala Ala Gly His Arg Pro Gly Val Asn         115 120 125 Leu Ala Ala Ala Ala Ser Gly Leu Trp Ser Leu Pro Met Ala Leu Ile     130 135 140 Gly Asn Ile Thr Thr Cys Leu Thr Gly Pro Thr Asn Ala Leu Ile Val 145 150 155 160 Ala Gly Ala Lys Ser His                 165 <210> 407 <211> 1280 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (1257) <223> RXN00571 <400> 407 aca ctt gtt cca cag gtt tac gaa ata gtg atc tac ggc gct gtg ctg 48 Thr Leu Val Pro Gln Val Tyr Glu Ile Val Ile Tyr Gly Ala Val Leu   1 5 10 15 tca gct gta cat gaa gat cca acc cag atc ggt gcg ctc agc cca gca 96 Ser Ala Val His Glu Asp Pro Thr Gln Ile Gly Ala Leu Ser Pro Ala              20 25 30 gtc gcc ggc acc ctt ggt tcc tac gcc atg atc ggc gtg atg atc ggt 144 Val Ala Gly Thr Leu Gly Ser Tyr Ala Met Ile Gly Val Met Ile Gly          35 40 45 gct cta tct gca ggt gcc gtt ggt gac cgc ctt ggt cgt cgc aaa gtt 192 Ala Leu Ser Ala Gly Ala Val Gly Asp Arg Leu Gly Arg Arg Lys Val      50 55 60 atg ctc acc gca atc gtc tgg ttc tct gtg ggc atg gcg ctg acc gcg 240 Met Leu Thr Ala Ile Val Trp Phe Ser Val Gly Met Ala Leu Thr Ala  65 70 75 80 ttc gcg tcc tcg att gcg ctg ttc ggt ttc ttg cgc ttc ctc acc gga 288 Phe Ala Ser Ser Ile Ala Leu Phe Gly Phe Leu Arg Phe Leu Thr Gly                  85 90 95 ctt ggc gtg ggc atg atc gtt gca acc ggc ggc gca atc atc gcg gag 336 Leu Gly Val Gly Met Ile Val Ala Thr Gly Gly Ala Ile Ile Ala Glu             100 105 110 ttc gct cca gcg aat agg cgc aac ttg ttc aac gca atc gtg tac tcc 384 Phe Ala Pro Ala Asn Arg Arg Asn Leu Phe Asn Ala Ile Val Tyr Ser         115 120 125 ggt gtc cca gcc ggt ggc gtg ctg gct tct atc ctt gca ctg ctc ttt 432 Gly Val Pro Ala Gly Gly Val Leu Ala Ser Ile Leu Ala Leu Leu Phe     130 135 140 gaa gat gtc atc ggc tgg cgc gga ctc ttc ctc atc ggt gga tcc cca 480 Glu Asp Val Ile Gly Trp Arg Gly Leu Phe Leu Ile Gly Gly Ser Pro 145 150 155 160 cta ctg ttc ctc ctg cca ctt gca tac ttc ttc ctc cca gag tcc ccg 528 Leu Leu Phe Leu Leu Pro Leu Ala Tyr Phe Phe Leu Pro Glu Ser Pro                 165 170 175 cgc tgg ctc acc tcc cgc ggc cgt gct gcg gac gcc aaa gcc ctc tgc 576 Arg Trp Leu Thr Ser Arg Gly Arg Ala Ala Asp Ala Lys Ala Leu Cys             180 185 190 gca cgc tat ggg ctg ccg acg gag gaa ttt gtc gtc gaa aag cag cag 624 Ala Arg Tyr Gly Leu Pro Thr Glu Glu Phe Val Val Glu Lys Gln Gln         195 200 205 gaa aca aag ggc acc gga ttc gct gga att ttc tcc tcc aag tac ctc 672 Glu Thr Lys Gly Thr Gly Phe Ala Gly Ile Phe Ser Ser Lys Tyr Leu     210 215 220 atg ggc acc att ctc atc ggc gca atg agc ttc atc ggg ctg ctt tcg 720 Met Gly Thr Ile Leu Ile Gly Ala Met Ser Phe Ile Gly Leu Leu Ser 225 230 235 240 acc tac ggc ctg aac acc tgg ttg cca aag atc atg gaa tcc aac ggc 768 Thr Tyr Gly Leu Asn Thr Trp Leu Pro Lys Ile Met Glu Ser Asn Gly                 245 250 255 gca acc tca cat gat tcc ctg tac tcc ctg ctg ttc ctc aac ggc ggc 816 Ala Thr Ser His Asp Ser Leu Tyr Ser Leu Leu Phe Leu Asn Gly Gly             260 265 270 gca gtg ttc ggt ggc ctc atc gca tcc tgg ttc gct gac cgc atc ggc 864 Ala Val Phe Gly Gly Leu Ile Ala Ser Trp Phe Ala Asp Arg Ile Gly         275 280 285 gcg aag acc gtg atc acc tcc acc ttc gct ctc gcc gcg atc tgc ctc 912 Ala Lys Thr Val Ile Thr Ser Thr Phe Ala Leu Ala Ala Ile Cys Leu     290 295 300 gga gtc ctg cca aac atc tcc tcc tgg cca atg atg tac acc gca atc 960 Gly Val Leu Pro Asn Ile Ser Ser Trp Pro Met Met Tyr Thr Ala Ile 305 310 315 320 gca ttc gca ggc gtc ggc gtc ctg ggc acc cag gtt ctc acc tac ggc 1008 Ala Phe Ala Gly Val Gly Val Leu Gly Thr Gln Val Leu Thr Tyr Gly                 325 330 335 ctg acc tcg aac ttc ttc gga acc gaa tgc cgc gca gcg gga gtt gca 1056 Leu Thr Ser Asn Phe Phe Gly Thr Glu Cys Arg Ala Ala Gly Val Ala             340 345 350 tgg tgt gca gga ttc ggc cga ctc ggc gga atc gtc gga cca gca atc 1104 Trp Cys Ala Gly Phe Gly Arg Leu Gly Gly Ile Val Gly Pro Ala Ile         355 360 365 ggt ggc ctg atc atc ggc gca gga ttc gga cca agc tcc gca ttc ctc 1152 Gly Gly Leu Ile Ile Gly Ala Gly Phe Gly Pro Ser Ser Ala Phe Leu     370 375 380 atc ttc gca gca gct gcc gca atc ggc gcg gtc tgc acc ttg ctg atc 1200 Ile Phe Ala Ala Ala Ala Ala Ile Gly Ala Val Cys Thr Leu Leu Ile 385 390 395 400 ccg cgc tcc cca gca gaa gta gag gtc aag gtc gcg cag gaa cca ctt 1248 Pro Arg Ser Pro Ala Glu Val Glu Val Lys Val Ala Gln Glu Pro Leu                 405 410 415 gca cgt gtc taaccccaat taattcgaaa caa 1280 Ala arg val <210> 408 <211> 419 <212> PRT <213> Corynebacterium glutamicum <400> 408 Thr Leu Val Pro Gln Val Tyr Glu Ile Val Ile Tyr Gly Ala Val Leu   1 5 10 15 Ser Ala Val His Glu Asp Pro Thr Gln Ile Gly Ala Leu Ser Pro Ala              20 25 30 Val Ala Gly Thr Leu Gly Ser Tyr Ala Met Ile Gly Val Met Ile Gly          35 40 45 Ala Leu Ser Ala Gly Ala Val Gly Asp Arg Leu Gly Arg Arg Lys Val      50 55 60 Met Leu Thr Ala Ile Val Trp Phe Ser Val Gly Met Ala Leu Thr Ala  65 70 75 80 Phe Ala Ser Ser Ile Ala Leu Phe Gly Phe Leu Arg Phe Leu Thr Gly                  85 90 95 Leu Gly Val Gly Met Ile Val Ala Thr Gly Gly Ala Ile Ile Ala Glu             100 105 110 Phe Ala Pro Ala Asn Arg Arg Asn Leu Phe Asn Ala Ile Val Tyr Ser         115 120 125 Gly Val Pro Ala Gly Gly Val Leu Ala Ser Ile Leu Ala Leu Leu Phe     130 135 140 Glu Asp Val Ile Gly Trp Arg Gly Leu Phe Leu Ile Gly Gly Ser Pro 145 150 155 160 Leu Leu Phe Leu Leu Pro Leu Ala Tyr Phe Phe Leu Pro Glu Ser Pro                 165 170 175 Arg Trp Leu Thr Ser Arg Gly Arg Ala Ala Asp Ala Lys Ala Leu Cys             180 185 190 Ala Arg Tyr Gly Leu Pro Thr Glu Glu Phe Val Val Glu Lys Gln Gln         195 200 205 Glu Thr Lys Gly Thr Gly Phe Ala Gly Ile Phe Ser Ser Lys Tyr Leu     210 215 220 Met Gly Thr Ile Leu Ile Gly Ala Met Ser Phe Ile Gly Leu Leu Ser 225 230 235 240 Thr Tyr Gly Leu Asn Thr Trp Leu Pro Lys Ile Met Glu Ser Asn Gly                 245 250 255 Ala Thr Ser His Asp Ser Leu Tyr Ser Leu Leu Phe Leu Asn Gly Gly             260 265 270 Ala Val Phe Gly Gly Leu Ile Ala Ser Trp Phe Ala Asp Arg Ile Gly         275 280 285 Ala Lys Thr Val Ile Thr Ser Thr Phe Ala Leu Ala Ala Ile Cys Leu     290 295 300 Gly Val Leu Pro Asn Ile Ser Ser Trp Pro Met Met Tyr Thr Ala Ile 305 310 315 320 Ala Phe Ala Gly Val Gly Val Leu Gly Thr Gln Val Leu Thr Tyr Gly                 325 330 335 Leu Thr Ser Asn Phe Phe Gly Thr Glu Cys Arg Ala Ala Gly Val Ala             340 345 350 Trp Cys Ala Gly Phe Gly Arg Leu Gly Gly Ile Val Gly Pro Ala Ile         355 360 365 Gly Gly Leu Ile Ile Gly Ala Gly Phe Gly Pro Ser Ser Ala Phe Leu     370 375 380 Ile Phe Ala Ala Ala Ala Ala Ile Gly Ala Val Cys Thr Leu Leu Ile 385 390 395 400 Pro Arg Ser Pro Ala Glu Val Glu Val Lys Val Ala Gln Glu Pro Leu                 405 410 415 Ala arg val <210> 409 <211> 1208 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (1185) <223> FRXA00571 <400> 409 cag atc ggt gcg ctc agc cca gca gtc gcc ggc acc ctt ggt tcc tac 48 Gln Ile Gly Ala Leu Ser Pro Ala Val Ala Gly Thr Leu Gly Ser Tyr   1 5 10 15 gcc atg atc ggc gtg atg atc ggt gct cta tct gca ggt gcc gtt ggt 96 Ala Met Ile Gly Val Met Ile Gly Ala Leu Ser Ala Gly Ala Val Gly              20 25 30 gac cgc ctt ggt cgt cgc aaa gtt atg ctc acc gca atc gtc tgg ttc 144 Asp Arg Leu Gly Arg Arg Lys Val Met Leu Thr Ala Ile Val Trp Phe          35 40 45 tct gtg ggc atg gcg ctg acc gcg ttc gcg tcc tcg att gcg ctg ttc 192 Ser Val Gly Met Ala Leu Thr Ala Phe Ala Ser Ser Ile Ala Leu Phe      50 55 60 ggt ttc ttg cgc ttc ctc acc gga ctt ggc gtg ggc atg atc gtt gca 240 Gly Phe Leu Arg Phe Leu Thr Gly Leu Gly Val Gly Met Ile Val Ala  65 70 75 80 acc ggc ggc gca atc atc gcg gag ttc gct cca gcg aat agg cgc aac 288 Thr Gly Gly Ala Ile Ile Ala Glu Phe Ala Pro Ala Asn Arg Arg Asn                  85 90 95 ttg ttc aac gca atc gtg tac tcc ggt gtc cca gcc ggt ggc gtg ctg 336 Leu Phe Asn Ala Ile Val Tyr Ser Gly Val Pro Ala Gly Gly Val Leu             100 105 110 gct tct atc ctt gca ctg ctc ttt gaa gat gtc atc ggc tgg cgc gga 384 Ala Ser Ile Leu Ala Leu Leu Phe Glu Asp Val Ile Gly Trp Arg Gly         115 120 125 ctc ttc ctc atc ggt gga tcc cca cta ctg ttc ctc ctg cca ctt gca 432 Leu Phe Leu Ile Gly Gly Ser Pro Leu Leu Phe Leu Leu Pro Leu Ala     130 135 140 tac ttc ttc ctc cca gag tcc ccg cgc tgg ctc acc tcc cgc ggc cgt 480 Tyr Phe Phe Leu Pro Glu Ser Pro Arg Trp Leu Thr Ser Arg Gly Arg 145 150 155 160 gct gcg gac gcc aaa gcc ctc tgc gca cgc tat ggg ctg ccg acg gag 528 Ala Ala Asp Ala Lys Ala Leu Cys Ala Arg Tyr Gly Leu Pro Thr Glu                 165 170 175 gaa ttt gtc gtc gaa aag cag cag gaa aca aag ggc acc gga ttc gct 576 Glu Phe Val Val Glu Lys Gln Gln Glu Thr Lys Gly Thr Gly Phe Ala             180 185 190 gga att ttc tcc tcc aag tac ctc atg ggc acc att ctc atc ggc gca 624 Gly Ile Phe Ser Ser Lys Tyr Leu Met Gly Thr Ile Leu Ile Gly Ala         195 200 205 atg agc ttc atc ggg ctg ctt tcg acc tac ggc ctg aac acc tgg ttg 672 Met Ser Phe Ile Gly Leu Leu Ser Thr Tyr Gly Leu Asn Thr Trp Leu     210 215 220 cca aag atc atg gaa tcc aac ggc gca acc tca cat gat tcc ctg tac 720 Pro Lys Ile Met Glu Ser Asn Gly Ala Thr Ser His Asp Ser Leu Tyr 225 230 235 240 tcc ctg ctg ttc ctc aac ggc ggc gca gtg ttc ggt ggc ctc atc gca 768 Ser Leu Leu Phe Leu Asn Gly Gly Ala Val Phe Gly Gly Leu Ile Ala                 245 250 255 tcc tgg ttc gct gac cgc atc ggc gcg aag acc gtg atc acc tcc acc 816 Ser Trp Phe Ala Asp Arg Ile Gly Ala Lys Thr Val Ile Thr Ser Thr             260 265 270 ttc gct ctc gcc gcg atc tgc ctc gga gtc ctg cca aac atc tcc tcc 864 Phe Ala Leu Ala Ala Ile Cys Leu Gly Val Leu Pro Asn Ile Ser Ser         275 280 285 tgg cca atg atg tac acc gca atc gca ttc gca ggc gtc ggc gtc ctg 912 Trp Pro Met Met Tyr Thr Ala Ile Ala Phe Ala Gly Val Gly Val Leu     290 295 300 ggc acc cag gtt ctc acc tac ggc ctg acc tcg aac ttc ttc gga acc 960 Gly Thr Gln Val Leu Thr Tyr Gly Leu Thr Ser Asn Phe Phe Gly Thr 305 310 315 320 gaa tgc cgc gca gcg gga gtt gca tgg tgt gca gga ttc ggc cga ctc 1008 Glu Cys Arg Ala Ala Gly Val Ala Trp Cys Ala Gly Phe Gly Arg Leu                 325 330 335 ggc gga atc gtc gga cca gca atc ggt ggc ctg atc atc ggc gca gga 1056 Gly Gly Ile Val Gly Pro Ala Ile Gly Gly Leu Ile Ile Gly Ala Gly             340 345 350 ttc gga cca agc tcc gca ttc ctc atc ttc gca gca gct gcc gca atc 1104 Phe Gly Pro Ser Ser Ala Phe Leu Ile Phe Ala Ala Ala Ala Ala Ile         355 360 365 ggc gcg gtc tgc acc ttg ctg atc ccg cgc tcc cca gca gaa gta gag 1152 Gly Ala Val Cys Thr Leu Leu Ile Pro Arg Ser Pro Ala Glu Val Glu     370 375 380 gtc aag gtc gcg cag gaa cca ctt gca cgt gtc taaccccaat taattcgaaa 1205 Val Lys Val Ala Gln Glu Pro Leu Ala Arg Val 385 390 395 caa 1208 <210> 410 <211> 395 <212> PRT <213> Corynebacterium glutamicum <400> 410 Gln Ile Gly Ala Leu Ser Pro Ala Val Ala Gly Thr Leu Gly Ser Tyr   1 5 10 15 Ala Met Ile Gly Val Met Ile Gly Ala Leu Ser Ala Gly Ala Val Gly              20 25 30 Asp Arg Leu Gly Arg Arg Lys Val Met Leu Thr Ala Ile Val Trp Phe          35 40 45 Ser Val Gly Met Ala Leu Thr Ala Phe Ala Ser Ser Ile Ala Leu Phe      50 55 60 Gly Phe Leu Arg Phe Leu Thr Gly Leu Gly Val Gly Met Ile Val Ala  65 70 75 80 Thr Gly Gly Ala Ile Ile Ala Glu Phe Ala Pro Ala Asn Arg Arg Asn                  85 90 95 Leu Phe Asn Ala Ile Val Tyr Ser Gly Val Pro Ala Gly Gly Val Leu             100 105 110 Ala Ser Ile Leu Ala Leu Leu Phe Glu Asp Val Ile Gly Trp Arg Gly         115 120 125 Leu Phe Leu Ile Gly Gly Ser Pro Leu Leu Phe Leu Leu Pro Leu Ala     130 135 140 Tyr Phe Phe Leu Pro Glu Ser Pro Arg Trp Leu Thr Ser Arg Gly Arg 145 150 155 160 Ala Ala Asp Ala Lys Ala Leu Cys Ala Arg Tyr Gly Leu Pro Thr Glu                 165 170 175 Glu Phe Val Val Glu Lys Gln Gln Glu Thr Lys Gly Thr Gly Phe Ala             180 185 190 Gly Ile Phe Ser Ser Lys Tyr Leu Met Gly Thr Ile Leu Ile Gly Ala         195 200 205 Met Ser Phe Ile Gly Leu Leu Ser Thr Tyr Gly Leu Asn Thr Trp Leu     210 215 220 Pro Lys Ile Met Glu Ser Asn Gly Ala Thr Ser His Asp Ser Leu Tyr 225 230 235 240 Ser Leu Leu Phe Leu Asn Gly Gly Ala Val Phe Gly Gly Leu Ile Ala                 245 250 255 Ser Trp Phe Ala Asp Arg Ile Gly Ala Lys Thr Val Ile Thr Ser Thr             260 265 270 Phe Ala Leu Ala Ala Ile Cys Leu Gly Val Leu Pro Asn Ile Ser Ser         275 280 285 Trp Pro Met Met Tyr Thr Ala Ile Ala Phe Ala Gly Val Gly Val Leu     290 295 300 Gly Thr Gln Val Leu Thr Tyr Gly Leu Thr Ser Asn Phe Phe Gly Thr 305 310 315 320 Glu Cys Arg Ala Ala Gly Val Ala Trp Cys Ala Gly Phe Gly Arg Leu                 325 330 335 Gly Gly Ile Val Gly Pro Ala Ile Gly Gly Leu Ile Ile Gly Ala Gly             340 345 350 Phe Gly Pro Ser Ser Ala Phe Leu Ile Phe Ala Ala Ala Ala Ala Ile         355 360 365 Gly Ala Val Cys Thr Leu Leu Ile Pro Arg Ser Pro Ala Glu Val Glu     370 375 380 Val Lys Val Ala Gln Glu Pro Leu Ala Arg Val 385 390 395 <210> 411 <211> 689 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (666) <223> RXA00962 <400> 411 gat aag gcc atc aag gcg gat cac gac att aga gaa ggc cac gat gag 48 Asp Lys Ala Ile Lys Ala Asp His Asp Ile Arg Glu Gly His Asp Glu   1 5 10 15 cca gca ggt ttc aag gat ctg ctt gtc gat cgc tac cgc tgg atc tcc 96 Pro Ala Gly Phe Lys Asp Leu Leu Val Asp Arg Tyr Arg Trp Ile Ser              20 25 30 att tgg ttc gcg ctc gcc aca ttt gtc acc ctg ctc gcg tgg tac gga 144 Ile Trp Phe Ala Leu Ala Thr Phe Val Thr Leu Leu Ala Trp Tyr Gly          35 40 45 ctg ggc aca tgg ttg cct cgc ctc atg gaa act gca ggt tat gag ttc 192 Leu Gly Thr Trp Leu Pro Arg Leu Met Glu Thr Ala Gly Tyr Glu Phe      50 55 60 ggc cat gca ttg atg ttc acc ctg gct ctg aac ctc ggt gca gtg atc 240 Gly His Ala Leu Met Phe Thr Leu Ala Leu Asn Leu Gly Ala Val Ile  65 70 75 80 gga tcc gtg gtt act gcg tgg gcc ggc gat cgc ttc ggg cca atc cgt 288 Gly Ser Val Val Thr Ala Trp Ala Gly Asp Arg Phe Gly Pro Ile Arg                  85 90 95 tcc ggt gtc atc gct gca ggt atc gcc ggt att gca ctg ctc ctg ctg 336 Ser Gly Val Ile Ala Ala Gly Ile Ala Gly Ile Ala Leu Leu Leu Leu             100 105 110 ctc act tac ccg cct gtc acc gcg gtt tat gtc att ctc att ttg gct 384 Leu Thr Tyr Pro Pro Val Thr Ala Val Tyr Val Ile Leu Ile Leu Ala         115 120 125 ggc gtg ggc acc cac ggc act cag atc ctc atc att gca gct gtc gcc 432 Gly Val Gly Thr His Gly Thr Gln Ile Leu Ile Ile Ala Ala Val Ala     130 135 140 aac ttc tac cca agc aac ctg cgt ggc aca gca ctg ggc tgg gcg cta 480 Asn Phe Tyr Pro Ser Asn Leu Arg Gly Thr Ala Leu Gly Trp Ala Leu 145 150 155 160 ggt gta ggt cgt att ggt gct gtt gtg gcc ccg cag ctc gct ggc ctg 528 Gly Val Gly Arg Ile Gly Ala Val Val Ala Pro Gln Leu Ala Gly Leu                 165 170 175 ctg ctg gca tgg aac ttg ggc gtg aac tcc aac ttc atc atg ttc ggc 576 Leu Leu Ala Trp Asn Leu Gly Val Asn Ser Asn Phe Ile Met Phe Gly             180 185 190 acc gct gcg ctg ctc tct gcg ctg gct ctc agc gtg ttg ctg cgc ctg 624 Thr Ala Ala Leu Leu Ser Ala Leu Ala Leu Ser Val Leu Leu Arg Leu         195 200 205 cag aaa acc tac agc gtc acc cac aaa gtc gaa atc caa ggc 666 Gln Lys Thr Tyr Ser Val Thr His Lys Val Glu Ile Gln Gly     210 215 220 taaccccctt tttcaactca cag 689 <210> 412 <211> 222 <212> PRT <213> Corynebacterium glutamicum <400> 412 Asp Lys Ala Ile Lys Ala Asp His Asp Ile Arg Glu Gly His Asp Glu   1 5 10 15 Pro Ala Gly Phe Lys Asp Leu Leu Val Asp Arg Tyr Arg Trp Ile Ser              20 25 30 Ile Trp Phe Ala Leu Ala Thr Phe Val Thr Leu Leu Ala Trp Tyr Gly          35 40 45 Leu Gly Thr Trp Leu Pro Arg Leu Met Glu Thr Ala Gly Tyr Glu Phe      50 55 60 Gly His Ala Leu Met Phe Thr Leu Ala Leu Asn Leu Gly Ala Val Ile  65 70 75 80 Gly Ser Val Val Thr Ala Trp Ala Gly Asp Arg Phe Gly Pro Ile Arg                  85 90 95 Ser Gly Val Ile Ala Ala Gly Ile Ala Gly Ile Ala Leu Leu Leu Leu             100 105 110 Leu Thr Tyr Pro Pro Val Thr Ala Val Tyr Val Ile Leu Ile Leu Ala         115 120 125 Gly Val Gly Thr His Gly Thr Gln Ile Leu Ile Ile Ala Ala Val Ala     130 135 140 Asn Phe Tyr Pro Ser Asn Leu Arg Gly Thr Ala Leu Gly Trp Ala Leu 145 150 155 160 Gly Val Gly Arg Ile Gly Ala Val Val Ala Pro Gln Leu Ala Gly Leu                 165 170 175 Leu Leu Ala Trp Asn Leu Gly Val Asn Ser Asn Phe Ile Met Phe Gly             180 185 190 Thr Ala Ala Leu Leu Ser Ala Leu Ala Leu Ser Val Leu Leu Arg Leu         195 200 205 Gln Lys Thr Tyr Ser Val Thr His Lys Val Glu Ile Gln Gly     210 215 220 <210> 413 <211> 484 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (484) <223> RXA02811 <400> 413 cataatcact ctttccagat agcggaatcc ctttgattgt aacttggctc acctcgatta 60 tgtgtttatg acatcacacg caccagaatc gggaggactt gtg aca gag tca act 115                                             Val Thr Glu Ser Thr                                               1 5 ctc gga gca tcg aat agc tcc caa aca att gaa aat aaa ggc ctc acc 163 Leu Gly Ala Ser Asn Ser Ser Gln Thr Ile Glu Asn Lys Gly Leu Thr                  10 15 20 atc ttg ggc atc agc ggc cga cgc ttg gct gcg gtg ctc att ggc tgg 211 Ile Leu Gly Ile Ser Gly Arg Arg Leu Ala Ala Val Leu Ile Gly Trp              25 30 35 ttt ttt gtc att ttc gac ggc tac gac ctc att gtg tac ggc acc gtc 259 Phe Phe Val Ile Phe Asp Gly Tyr Asp Leu Ile Val Tyr Gly Thr Val          40 45 50 caa tcg gcc ctg gct aag gag tgg aac tta agc tct gca acg ctg ggc 307 Gln Ser Ala Leu Ala Lys Glu Trp Asn Leu Ser Ser Ala Thr Leu Gly      55 60 65 acc atc ggc tcc acc gcg ttc ttt ggc atg gcg atc ggc gct gtg ttc 355 Thr Ile Gly Ser Thr Ala Phe Phe Gly Met Ala Ile Gly Ala Val Phe  70 75 80 85 att ggt cga ctg tca gac cgc gtg ggc cga aaa gca gcg gtg att gga 403 Ile Gly Arg Leu Ser Asp Arg Val Gly Arg Lys Ala Ala Val Ile Gly                  90 95 100 tcc gtg ctg att ctc tct gtc ttc acc atg ctg tgt gca ttt gct cca 451 Ser Val Leu Ile Leu Ser Val Phe Thr Met Leu Cys Ala Phe Ala Pro             105 110 115 aac cca tgg gtg ttc ggc gct ttc cgt ttc atc 484 Asn Pro Trp Val Phe Gly Ala Phe Arg Phe Ile         120 125 <210> 414 <211> 128 <212> PRT <213> Corynebacterium glutamicum <400> 414 Val Thr Glu Ser Thr Leu Gly Ala Ser Asn Ser Ser Gln Thr Ile Glu   1 5 10 15 Asn Lys Gly Leu Thr Ile Leu Gly Ile Ser Gly Arg Arg Leu Ala Ala              20 25 30 Val Leu Ile Gly Trp Phe Phe Val Ile Phe Asp Gly Tyr Asp Leu Ile          35 40 45 Val Tyr Gly Thr Val Gln Ser Ala Leu Ala Lys Glu Trp Asn Leu Ser      50 55 60 Ser Ala Thr Leu Gly Thr Ile Gly Ser Thr Ala Phe Phe Gly Met Ala  65 70 75 80 Ile Gly Ala Val Phe Ile Gly Arg Leu Ser Asp Arg Val Gly Arg Lys                  85 90 95 Ala Ala Val Ile Gly Ser Val Leu Ile Leu Ser Val Phe Thr Met Leu             100 105 110 Cys Ala Phe Ala Pro Asn Pro Trp Val Phe Gly Ala Phe Arg Phe Ile         115 120 125 <210> 415 <211> 1197 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (1197) <223> RXA02115 <400> 415 acc cgc gca acc aaa agt gtc gga aca gtt ctc gca ctc ctg tgg ttc 48 Thr Arg Ala Thr Lys Ser Val Gly Thr Val Leu Ala Leu Leu Trp Phe   1 5 10 15 gca att gtc ctc gac ggc ttt gac cta gtc gtc ctg ggt gca aca atc 96 Ala Ile Val Leu Asp Gly Phe Asp Leu Val Val Leu Gly Ala Thr Ile              20 25 30 ccg tcc atg ctg gag gat ccc gcg tgg gat ctc act gct gga cag gcc 144 Pro Ser Met Leu Glu Asp Pro Ala Trp Asp Leu Thr Ala Gly Gln Ala          35 40 45 aca cag att tcc acc atc ggc ctc gtc ggc atg acc att ggc gca ctg 192 Thr Gln Ile Ser Thr Ile Gly Leu Val Gly Met Thr Ile Gly Ala Leu      50 55 60 acc atc ggt ttc tta acg gac cgt ctg ggt cga cgc cgt gtc atg ctg 240 Thr Ile Gly Phe Leu Thr Asp Arg Leu Gly Arg Arg Arg Val Met Leu  65 70 75 80 ttc tct gtg gca gta ttt tct gta ttc act ctc ctg ctg gca ttc acc 288 Phe Ser Val Ala Val Phe Ser Val Phe Thr Leu Leu Leu Ala Phe Thr                  85 90 95 acc aac gtc cag ctc ttc agc ctg tgg cgt ttc ctc gca ggt gtt ggc 336 Thr Asn Val Gln Leu Phe Ser Leu Trp Arg Phe Leu Ala Gly Val Gly             100 105 110 ctt ggt gga gca ctc ccc acc gca att gcc atg gtg acc gag ttc cgc 384 Leu Gly Gly Ala Leu Pro Thr Ala Ile Ala Met Val Thr Glu Phe Arg         115 120 125 ccc ggc acc aaa gcg ggc tct gca tcc acc acc ttg atg acc ggc tac 432 Pro Gly Thr Lys Ala Gly Ser Ala Ser Thr Thr Leu Met Thr Gly Tyr     130 135 140 cac gtc ggc gca gta gca acc gcc ttc ctt ggc ctc ttc ctt atc gac 480 His Val Gly Ala Val Ala Thr Ala Phe Leu Gly Leu Phe Leu Ile Asp 145 150 155 160 ggc ttt ggt tgg cac tcc atg ttc atc gca ggt gcc gta cca gga ctg 528 Gly Phe Gly Trp His Ser Met Phe Ile Ala Gly Ala Val Pro Gly Leu                 165 170 175 atc ctg cta cca ctg ctg tac ttc ttc ctt cca gaa tcc ccg cag tac 576 Ile Leu Leu Pro Leu Leu Tyr Phe Phe Leu Pro Glu Ser Pro Gln Tyr             180 185 190 ctc aaa atc tcc ggc aag ttg gat gag gcg cag gca gtt gca gca tct 624 Leu Lys Ile Ser Gly Lys Leu Asp Glu Ala Gln Ala Val Ala Ala Ser         195 200 205 tat gga ctt tcc ctg gat gat gat ctt gat cgc gaa cac gaa gaa gaa 672 Tyr Gly Leu Ser Leu Asp Asp Asp Leu Asp Arg Glu His Glu Glu Glu     210 215 220 ctc ggc gag tcc tcc tca ctt tcc tcc ctg ttc aag ccc tcg ttc cgc 720 Leu Gly Glu Ser Ser Ser Leu Ser Ser Leu Phe Lys Pro Ser Phe Arg 225 230 235 240 cgc aac acc ctg gcg att tgg ggc acc tca ttc atg gga ctc ctc ctg 768 Arg Asn Thr Leu Ala Ile Trp Gly Thr Ser Phe Met Gly Leu Leu Leu                 245 250 255 gtc tac ggc ctg aac aca tgg ctg cca caa atc atg cgc caa gca gac 816 Val Tyr Gly Leu Asn Thr Trp Leu Pro Gln Ile Met Arg Gln Ala Asp             260 265 270 tac gac atg ggt aac tcg ctt gga ttc ctc atg gtg ctc aac atc ggc 864 Tyr Asp Met Gly Asn Ser Leu Gly Phe Leu Met Val Leu Asn Ile Gly         275 280 285 gca gtg atc ggc ctt tat att gca ggg cga att gcc gat aag aac tcc 912 Ala Val Ile Gly Leu Tyr Ile Ala Gly Arg Ile Ala Asp Lys Asn Ser     290 295 300 cct cgc aaa aca gca ctc gta tgg ttc gtg ttc tct gca ttt tcc ctc 960 Pro Arg Lys Thr Ala Leu Val Trp Phe Val Phe Ser Ala Phe Ser Leu 305 310 315 320 gcg ttg ctt gct gtc cgg atg cca ctg atc ggt ctg tat ggc atc gtg 1008 Ala Leu Leu Ala Val Arg Met Pro Leu Ile Gly Leu Tyr Gly Ile Val                 325 330 335 ctg ctc acc ggc atc ttt gtg ttc agc tcc cag gta ctc atc tac gcc 1056 Leu Leu Thr Gly Ile Phe Val Phe Ser Ser Gln Val Leu Ile Tyr Ala             340 345 350 ttc gtt ggt gag aat cac cct gcc aag atg cgc gca acc gcc atg gga 1104 Phe Val Gly Glu Asn His Pro Ala Lys Met Arg Ala Thr Ala Met Gly         355 360 365 ttc tcc gca gga att ggt cgc ctc ggc gcc atc tct ggc ccg ttg ctt 1152 Phe Ser Ala Gly Ile Gly Arg Leu Gly Ala Ile Ser Gly Pro Leu Leu     370 375 380 ggt ggt ctg ctt gtc agt gcc aac ctt gct tac cca tgg ggc ttc 1197 Gly Gly Leu Leu Val Ser Ala Asn Leu Ala Tyr Pro Trp Gly Phe 385 390 395 <210> 416 <211> 399 <212> PRT <213> Corynebacterium glutamicum <400> 416 Thr Arg Ala Thr Lys Ser Val Gly Thr Val Leu Ala Leu Leu Trp Phe   1 5 10 15 Ala Ile Val Leu Asp Gly Phe Asp Leu Val Val Leu Gly Ala Thr Ile              20 25 30 Pro Ser Met Leu Glu Asp Pro Ala Trp Asp Leu Thr Ala Gly Gln Ala          35 40 45 Thr Gln Ile Ser Thr Ile Gly Leu Val Gly Met Thr Ile Gly Ala Leu      50 55 60 Thr Ile Gly Phe Leu Thr Asp Arg Leu Gly Arg Arg Arg Val Met Leu  65 70 75 80 Phe Ser Val Ala Val Phe Ser Val Phe Thr Leu Leu Leu Ala Phe Thr                  85 90 95 Thr Asn Val Gln Leu Phe Ser Leu Trp Arg Phe Leu Ala Gly Val Gly             100 105 110 Leu Gly Gly Ala Leu Pro Thr Ala Ile Ala Met Val Thr Glu Phe Arg         115 120 125 Pro Gly Thr Lys Ala Gly Ser Ala Ser Thr Thr Leu Met Thr Gly Tyr     130 135 140 His Val Gly Ala Val Ala Thr Ala Phe Leu Gly Leu Phe Leu Ile Asp 145 150 155 160 Gly Phe Gly Trp His Ser Met Phe Ile Ala Gly Ala Val Pro Gly Leu                 165 170 175 Ile Leu Leu Pro Leu Leu Tyr Phe Phe Leu Pro Glu Ser Pro Gln Tyr             180 185 190 Leu Lys Ile Ser Gly Lys Leu Asp Glu Ala Gln Ala Val Ala Ala Ser         195 200 205 Tyr Gly Leu Ser Leu Asp Asp Asp Leu Asp Arg Glu His Glu Glu Glu     210 215 220 Leu Gly Glu Ser Ser Ser Leu Ser Ser Leu Phe Lys Pro Ser Phe Arg 225 230 235 240 Arg Asn Thr Leu Ala Ile Trp Gly Thr Ser Phe Met Gly Leu Leu Leu                 245 250 255 Val Tyr Gly Leu Asn Thr Trp Leu Pro Gln Ile Met Arg Gln Ala Asp             260 265 270 Tyr Asp Met Gly Asn Ser Leu Gly Phe Leu Met Val Leu Asn Ile Gly         275 280 285 Ala Val Ile Gly Leu Tyr Ile Ala Gly Arg Ile Ala Asp Lys Asn Ser     290 295 300 Pro Arg Lys Thr Ala Leu Val Trp Phe Val Phe Ser Ala Phe Ser Leu 305 310 315 320 Ala Leu Leu Ala Val Arg Met Pro Leu Ile Gly Leu Tyr Gly Ile Val                 325 330 335 Leu Leu Thr Gly Ile Phe Val Phe Ser Ser Gln Val Leu Ile Tyr Ala             340 345 350 Phe Val Gly Glu Asn His Pro Ala Lys Met Arg Ala Thr Ala Met Gly         355 360 365 Phe Ser Ala Gly Ile Gly Arg Leu Gly Ala Ile Ser Gly Pro Leu Leu     370 375 380 Gly Gly Leu Leu Val Ser Ala Asn Leu Ala Tyr Pro Trp Gly Phe 385 390 395 <210> 417 <211> 1288 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (101) .. (1288) <223> RXN00590 <400> 417 tctaaactca ctctcaactc accaagattg ttcaacaatc tgcgattggt gtgcaatcta 60 ccccaatcat tttgaaagcc cccacgaaag gagcgcgaca atg gcc gac aac aaa 115                                             Met Ala Asp Asn Lys                                               1 5 aat gcc gat gac agc cag cta gtc tca gcc agc act gga acc cct ggg 163 Asn Ala Asp Asp Ser Gln Leu Val Ser Ala Ser Thr Gly Thr Pro Gly                  10 15 20 cct ggc gac att gca aaa gcc aat gcg cca tcc ctc aag caa gct gca 211 Pro Gly Asp Ile Ala Lys Ala Asn Ala Pro Ser Leu Lys Gln Ala Ala              25 30 35 gta acc gcc tct ggc cga agc gct ctg atg ggt gcc atc ttc ctc atg 259 Val Thr Ala Ser Gly Arg Ser Ala Leu Met Gly Ala Ile Phe Leu Met          40 45 50 gca act tct gcc atc ggc cca ggg ttc ctc acc caa acc gct gtc ttc 307 Ala Thr Ser Ala Ile Gly Pro Gly Phe Leu Thr Gln Thr Ala Val Phe      55 60 65 acc aac cag ctc ggc gca gct ttc gca ttt gcg atc ctg gtg tcg atc 355 Thr Asn Gln Leu Gly Ala Ala Phe Ala Phe Ala Ile Leu Val Ser Ile  70 75 80 85 ctc att gac atc gcg gtg cag ctg aat gtg tgg cgc atc atc ggc gtc 403 Leu Ile Asp Ile Ala Val Gln Leu Asn Val Trp Arg Ile Ile Gly Val                  90 95 100 tct gaa atg cgc gcc caa gaa ctc ggc aac acg gtt atc cca ggt ttt 451 Ser Glu Met Arg Ala Gln Glu Leu Gly Asn Thr Val Ile Pro Gly Phe             105 110 115 ggt tgg gtg ctg gcc gta ctg gtc tgt att ggc ggc gta gta ttc aac 499 Gly Trp Val Leu Ala Val Leu Val Cys Ile Gly Gly Val Val Phe Asn         120 125 130 atc ggc aac atc gcc ggt ggt ggc ctt ggg ctt aac gcg ctg ctt ggc 547 Ile Gly Asn Ile Ala Gly Gly Gly Leu Gly Leu Asn Ala Leu Leu Gly     135 140 145 tgg gac gtc aaa gtt ggt ggc gtg atc acc gcg gcc atc gcg att gcg 595 Trp Asp Val Lys Val Gly Gly Val Ile Thr Ala Ala Ile Ala Ile Ala 150 155 160 165 atc ttc ttg ttc aag cga ctt ggt gct gct ctg gac aaa ttc ctc gtg 643 Ile Phe Leu Phe Lys Arg Leu Gly Ala Ala Leu Asp Lys Phe Leu Val                 170 175 180 gtc ctc ggc gtc gtg atg atc ctg ctc acc gtc tac gtg gct ttc gtc 691 Val Leu Gly Val Val Met Ile Leu Leu Thr Val Tyr Val Ala Phe Val             185 190 195 tcc caa cct cca gtt ggc tcg gcg ctg aag aat gca gta ctt cct gac 739 Ser Gln Pro Pro Val Gly Ser Ala Leu Lys Asn Ala Val Leu Pro Asp         200 205 210 acc atc gac tgg ctt gtc atc acc aca ctt gtg ggt gga acc gtc ggt 787 Thr Ile Asp Trp Leu Val Ile Thr Thr Leu Val Gly Gly Thr Val Gly     215 220 225 gga tac atc act tac gct ggc gca cac cgc atg ctg gac tcc gga cga 835 Gly Tyr Ile Thr Tyr Ala Gly Ala His Arg Met Leu Asp Ser Gly Arg 230 235 240 245 acc ggc ccc aac aac gtc aaa gct gtt tcc aat tcc tct atc acc ggc 883 Thr Gly Pro Asn Asn Val Lys Ala Val Ser Asn Ser Ser Ile Thr Gly                 250 255 260 atc ctg atc act ggc ctc atg cgc gtg gtg ctc ttc ctc gcg gtt ctc 931 Ile Leu Ile Thr Gly Leu Met Arg Val Val Leu Phe Leu Ala Val Leu             265 270 275 ggt gtt gtc gca ggt ggc gtc acc cta tcc acc acg ggc aac cca gcc 979 Gly Val Val Ala Gly Gly Val Thr Leu Ser Thr Thr Gly Asn Pro Ala         280 285 290 gcg gaa gca ttc cag cac gct gca ggc gat atc gga cta cgc atc ttc 1027 Ala Glu Ala Phe Gln His Ala Ala Gly Asp Ile Gly Leu Arg Ile Phe     295 300 305 ggc gcc gtg ctg tgg gca gcg tcc att tcc tca gtc atc ggc gcc agc 1075 Gly Ala Val Leu Trp Ala Ala Ser Ile Ser Ser Val Ile Gly Ala Ser 310 315 320 325 tac acc tct gca acc ttc ctg gtg gaa aac aag cca gag aag aag cgt 1123 Tyr Thr Ser Ala Thr Phe Leu Val Glu Asn Lys Pro Glu Lys Lys Arg                 330 335 340 ctg caa aac tgg gtg acc atc atc ttc atc ctg att tct tgc tcc gtg 1171 Leu Gln Asn Trp Val Thr Ile Ile Phe Ile Leu Ile Ser Cys Ser Val             345 350 355 ttc atc atg ctc ggc acg gca cca gca atc ctc ttg gtc ttc gcc gga 1219 Phe Ile Met Leu Gly Thr Ala Pro Ala Ile Leu Leu Val Phe Ala Gly         360 365 370 gca ttc aac ggt ttg gtc ctc ccc gta ggc ttt acc ctg atg atc tac 1267 Ala Phe Asn Gly Leu Val Leu Pro Val Gly Phe Thr Leu Met Ile Tyr     375 380 385 gta gcg atc ttc cgc caa aaa 1288 Val Ala Ile Phe Arg Gln Lys 390 395 <210> 418 <211> 396 <212> PRT <213> Corynebacterium glutamicum <400> 418 Met Ala Asp Asn Lys Asn Ala Asp Asp Ser Gln Leu Val Ser Ala Ser   1 5 10 15 Thr Gly Thr Pro Gly Pro Gly Asp Ile Ala Lys Ala Asn Ala Pro Ser              20 25 30 Leu Lys Gln Ala Ala Val Thr Ala Ser Gly Arg Ser Ala Leu Met Gly          35 40 45 Ala Ile Phe Leu Met Ala Thr Ser Ala Ile Gly Pro Gly Phe Leu Thr      50 55 60 Gln Thr Ala Val Phe Thr Asn Gln Leu Gly Ala Ala Phe Ala Phe Ala  65 70 75 80 Ile Leu Val Ser Ile Leu Ile Asp Ile Ala Val Gln Leu Asn Val Trp                  85 90 95 Arg Ile Ile Gly Val Ser Glu Met Arg Ala Gln Glu Leu Gly Asn Thr             100 105 110 Val Ile Pro Gly Phe Gly Trp Val Leu Ala Val Leu Val Cys Ile Gly         115 120 125 Gly Val Val Phe Asn Ile Gly Asn Ile Ala Gly Gly Gly Leu Gly Leu     130 135 140 Asn Ala Leu Leu Gly Trp Asp Val Lys Val Gly Gly Val Ile Thr Ala 145 150 155 160 Ala Ile Ala Ile Ala Ile Phe Leu Phe Lys Arg Leu Gly Ala Ala Leu                 165 170 175 Asp Lys Phe Leu Val Val Leu Gly Val Val Met Ile Leu Leu Thr Val             180 185 190 Tyr Val Ala Phe Val Ser Gln Pro Pro Val Gly Ser Ala Leu Lys Asn         195 200 205 Ala Val Leu Pro Asp Thr Ile Asp Trp Leu Val Ile Thr Thr Leu Val     210 215 220 Gly Gly Thr Val Gly Gly Tyr Ile Thr Tyr Ala Gly Ala His Arg Met 225 230 235 240 Leu Asp Ser Gly Arg Thr Gly Pro Asn Asn Val Lys Ala Val Ser Asn                 245 250 255 Ser Ser Ile Thr Gly Ile Leu Ile Thr Gly Leu Met Arg Val Val Leu             260 265 270 Phe Leu Ala Val Leu Gly Val Val Ala Gly Gly Val Thr Leu Ser Thr         275 280 285 Thr Gly Asn Pro Ala Ala Glu Ala Phe Gln His Ala Ala Gly Asp Ile     290 295 300 Gly Leu Arg Ile Phe Gly Ala Val Leu Trp Ala Ala Ser Ile Ser Ser 305 310 315 320 Val Ile Gly Ala Ser Tyr Thr Ser Ala Thr Phe Leu Val Glu Asn Lys                 325 330 335 Pro Glu Lys Lys Arg Leu Gln Asn Trp Val Thr Ile Ile Phe Ile Leu             340 345 350 Ile Ser Cys Ser Val Phe Ile Met Leu Gly Thr Ala Pro Ala Ile Leu         355 360 365 Leu Val Phe Ala Gly Ala Phe Asn Gly Leu Val Leu Pro Val Gly Phe     370 375 380 Thr Leu Met Ile Tyr Val Ala Ile Phe Arg Gln Lys 385 390 395 <210> 419 <211> 487 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (101) .. (487) <223> FRXA00590 <400> 419 tacgctggcg cacaccgcat gctggactcc ggacgaaccg gccccaacac gtcaaagctg 60 tttccaattc tctatcaccg gcatcctgat cactggcctc atg cgc gtg gtg ctc 115                                             Met Arg Val Val Leu                                               1 5 ttc ctc gcg gtt ctc ggt gtt gtc gca ggt ggc gtc acc cta tcc acc 163 Phe Leu Ala Val Leu Gly Val Val Ala Gly Gly Val Thr Leu Ser Thr                  10 15 20 acg ggc aac cca gcc gcg gaa gca ttc cag cac gct gca ggc gat atc 211 Thr Gly Asn Pro Ala Ala Glu Ala Phe Gln His Ala Ala Gly Asp Ile              25 30 35 gga cta cgc atc ttc ggc gcc gtg ctg tgg gca gcg tcc att tcc tca 259 Gly Leu Arg Ile Phe Gly Ala Val Leu Trp Ala Ala Ser Ile Ser Ser          40 45 50 gtc atc ggc gcc agc tac acc tct gca acc ttc ctg gtg gaa aac aag 307 Val Ile Gly Ala Ser Tyr Thr Ser Ala Thr Phe Leu Val Glu Asn Lys      55 60 65 cca gag aag aag cgt ctg caa aac tgg gtg acc atc atc ttc atc ctg 355 Pro Glu Lys Lys Arg Leu Gln Asn Trp Val Thr Ile Ile Phe Ile Leu  70 75 80 85 att tct tgc tcc gtg ttc atc atg ctc ggc acg gca cca gca atc ctc 403 Ile Ser Cys Ser Val Phe Ile Met Leu Gly Thr Ala Pro Ala Ile Leu                  90 95 100 ttg gtc ttc gcc gga gca ttc aac ggt ttg gtc ctc ccc gta ggc ttt 451 Leu Val Phe Ala Gly Ala Phe Asn Gly Leu Val Leu Pro Val Gly Phe             105 110 115 acc ctg atg atc tac gta gcg atc ttc cgc caa aaa 487 Thr Leu Met Ile Tyr Val Ala Ile Phe Arg Gln Lys         120 125 <210> 420 <211> 129 <212> PRT <213> Corynebacterium glutamicum <400> 420 Met Arg Val Val Leu Phe Leu Ala Val Leu Gly Val Val Ala Gly Gly   1 5 10 15 Val Thr Leu Ser Thr Thr Gly Asn Pro Ala Ala Glu Ala Phe Gln His              20 25 30 Ala Ala Gly Asp Ile Gly Leu Arg Ile Phe Gly Ala Val Leu Trp Ala          35 40 45 Ala Ser Ile Ser Ser Val Ile Gly Ala Ser Tyr Thr Ser Ala Thr Phe      50 55 60 Leu Val Glu Asn Lys Pro Glu Lys Lys Arg Leu Gln Asn Trp Val Thr  65 70 75 80 Ile Ile Phe Ile Leu Ile Ser Cys Ser Val Phe Ile Met Leu Gly Thr                  85 90 95 Ala Pro Ala Ile Leu Leu Val Phe Ala Gly Ala Phe Asn Gly Leu Val             100 105 110 Leu Pro Val Gly Phe Thr Leu Met Ile Tyr Val Ala Ile Phe Arg Gln         115 120 125 Lys <210> 421 <211> 490 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (490) <223> FRXA01538 <400> 421 tctaaactca ctctcaactc accaagattg ttcaacaatc tgcgattggt gtgcaatcta 60 ccccaatcat tttgaaagcc cccacgaaag gagcgcgaca atg gcc gac aac aaa 115                                             Met Ala Asp Asn Lys                                               1 5 aat gcc gat gac agc cag cta gtc tca gcc agc act gga acc cct ggg 163 Asn Ala Asp Asp Ser Gln Leu Val Ser Ala Ser Thr Gly Thr Pro Gly                  10 15 20 cct ggc gac att gca aaa gcc aat gcg cca tcc ctc aag caa gct gca 211 Pro Gly Asp Ile Ala Lys Ala Asn Ala Pro Ser Leu Lys Gln Ala Ala              25 30 35 gta acc gcc tct ggc cga agc gct ctg atg ggt gcc atc ttc ctc atg 259 Val Thr Ala Ser Gly Arg Ser Ala Leu Met Gly Ala Ile Phe Leu Met          40 45 50 gca act tct gcc atc ggc cca ggg ttc ctc acc caa acc gct gtc ttc 307 Ala Thr Ser Ala Ile Gly Pro Gly Phe Leu Thr Gln Thr Ala Val Phe      55 60 65 acc aac cag ctc ggc gca gct ttc gca ttt gcg atc ctg gtg tcg atc 355 Thr Asn Gln Leu Gly Ala Ala Phe Ala Phe Ala Ile Leu Val Ser Ile  70 75 80 85 ctc att gac atc gcg gtg cag ctg aat gtg tgg cgc atc atc ggc gtc 403 Leu Ile Asp Ile Ala Val Gln Leu Asn Val Trp Arg Ile Ile Gly Val                  90 95 100 tct gaa atg cgc gcc caa gaa ctc ggc aac acg gtt atc cca ggt ttt 451 Ser Glu Met Arg Ala Gln Glu Leu Gly Asn Thr Val Ile Pro Gly Phe             105 110 115 ggt tgg gtg ctg gcc gta ctg gtc tgt att ggc ggc gta 490 Gly Trp Val Leu Ala Val Leu Val Cys Ile Gly Gly Val         120 125 130 <210> 422 <211> 130 <212> PRT <213> Corynebacterium glutamicum <400> 422 Met Ala Asp Asn Lys Asn Ala Asp Asp Ser Gln Leu Val Ser Ala Ser   1 5 10 15 Thr Gly Thr Pro Gly Pro Gly Asp Ile Ala Lys Ala Asn Ala Pro Ser              20 25 30 Leu Lys Gln Ala Ala Val Thr Ala Ser Gly Arg Ser Ala Leu Met Gly          35 40 45 Ala Ile Phe Leu Met Ala Thr Ser Ala Ile Gly Pro Gly Phe Leu Thr      50 55 60 Gln Thr Ala Val Phe Thr Asn Gln Leu Gly Ala Ala Phe Ala Phe Ala  65 70 75 80 Ile Leu Val Ser Ile Leu Ile Asp Ile Ala Val Gln Leu Asn Val Trp                  85 90 95 Arg Ile Ile Gly Val Ser Glu Met Arg Ala Gln Glu Leu Gly Asn Thr             100 105 110 Val Ile Pro Gly Phe Gly Trp Val Leu Ala Val Leu Val Cys Ile Gly         115 120 125 Gly val     130 <210> 423 <211> 1401 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1378) <223> RXA01727 <400> 423 agcttttggt ggtttcacca cctgcgctcg tcttaatttt gcgtgttcca gagagaccct 60 tgaggagggg ctgcgccgta tcgccagcgt gttgtaaata atg agt aaa aag tct 115                                             Met Ser Lys Lys Ser                                               1 5 gtc ctg att act tct ttg atg ctg ttt tcc atg ttc ttc gga gct gga 163 Val Leu Ile Thr Ser Leu Met Leu Phe Ser Met Phe Phe Gly Ala Gly                  10 15 20 aac ctc atc ttc ccg ccg atg ctt gga ttg tcg gca gga acc aac tat 211 Asn Leu Ile Phe Pro Pro Met Leu Gly Leu Ser Ala Gly Thr Asn Tyr              25 30 35 cta cca gct atc tta gga ttt cta gca acg agt gtt ctg ctc ccg gtg 259 Leu Pro Ala Ile Leu Gly Phe Leu Ala Thr Ser Val Leu Leu Pro Val          40 45 50 ctg gcg att atc gcg gtg gtg ttg tcg gga gaa aat gtc aag gac atg 307 Leu Ala Ile Ile Ala Val Val Leu Ser Gly Glu Asn Val Lys Asp Met      55 60 65 gct tct cgt ggc ggt aag atc ttt ggc ctg gtg ttt cct att gct gcc 355 Ala Ser Arg Gly Gly Lys Ile Phe Gly Leu Val Phe Pro Ile Ala Ala  70 75 80 85 tat ttg tct atc ggc gcg ttt tac gcg ctg ccg agg act ggg gcg gtg 403 Tyr Leu Ser Ile Gly Ala Phe Tyr Ala Leu Pro Arg Thr Gly Ala Val                  90 95 100 agc tat tcg acg gcg gtt ggc gtc gat aat gcg ctt tat tcg ggc ttg 451 Ser Tyr Ser Thr Ala Val Gly Val Asp Asn Ala Leu Tyr Ser Gly Leu             105 110 115 ttt aac ttt gtg ttt ttt gcg gtg gca ctg gcg ttg tcg tgg aat ccg 499 Phe Asn Phe Val Phe Phe Ala Val Ala Leu Ala Leu Ser Trp Asn Pro         120 125 130 aat ggc att gca gac aag ttg ggt aag tgg ctc acg cca gcg ttg ctc 547 Asn Gly Ile Ala Asp Lys Leu Gly Lys Trp Leu Thr Pro Ala Leu Leu     135 140 145 acg ttg att gtg gtg ctg gtg gtg ttg tcg gta gcc aag ttg gat ggc 595 Thr Leu Ile Val Val Leu Val Val Leu Ser Val Ala Lys Leu Asp Gly 150 155 160 165 acg cca ggt gag cca agt agt gcg tat gcg cag cag cct gcg ggg gcg 643 Thr Pro Gly Glu Pro Ser Ser Ala Tyr Ala Gln Gln Pro Ala Gly Ala                 170 175 180 ggt ttg ctt gag ggc tac atg acg atg gat gcg att gct gcg ttg gcg 691 Gly Leu Leu Glu Gly Tyr Met Thr Met Asp Ala Ile Ala Ala Leu Ala             185 190 195 ttt ggc atc gtg gtg att tct gcg ttc aag tac caa aag gtt aac aag 739 Phe Gly Ile Val Val Ile Ser Ala Phe Lys Tyr Gln Lys Val Asn Lys         200 205 210 gtc cgc acg gca act gtc gtg tcg gcg ttc att gcc gga att ttg ttg 787 Val Arg Thr Ala Thr Val Val Ser Ala Phe Ile Ala Gly Ile Leu Leu     215 220 225 gcg ctg gtt tat ctt ggt ttg ggc tca atc ggt caa gta gta aac ggt 835 Ala Leu Val Tyr Leu Gly Leu Gly Ser Ile Gly Gln Val Val Asn Gly 230 235 240 245 gag ttc gct gat ggc acc gca att ttg aac tac gct gca ctg tcc acg 883 Glu Phe Ala Asp Gly Thr Ala Ile Leu Asn Tyr Ala Ala Leu Ser Thr                 250 255 260 atg ggt cag gct ggt cgc atc atg ttc gtg gct att ttg atc ctt gca 931 Met Gly Gln Ala Gly Arg Ile Met Phe Val Ala Ile Leu Ile Leu Ala             265 270 275 tgt atg acc acc gca gtt ggt ctg atc agt gcg acg tct gag ttt ttc 979 Cys Met Thr Thr Ala Val Gly Leu Ile Ser Ala Thr Ser Glu Phe Phe         280 285 290 aat tcg ctg ctg cca ggt gtc aag tac cac gtc tgg gcc act gtt ttc 1027 Asn Ser Leu Leu Pro Gly Val Lys Tyr His Val Trp Ala Thr Val Phe     295 300 305 gcg ctg att tcc ttt ggc gtt gcc acc atg ggt ttg gat acg gtg ttg 1075 Ala Leu Ile Ser Phe Gly Val Ala Thr Met Gly Leu Asp Thr Val Leu 310 315 320 325 gcc gtt gcg gct cca gtg att agt ttc att tac cca tcg gcc atc acc 1123 Ala Val Ala Ala Pro Val Ile Ser Phe Ile Tyr Pro Ser Ala Ile Thr                 330 335 340 ttg gtg ttc ttg tcg ctc atc gag ccc ctg ctg ttc cgt ctc aag tgg 1171 Leu Val Phe Leu Ser Leu Ile Glu Pro Leu Leu Phe Arg Leu Lys Trp             345 350 355 acc tac cta ttc ggc att tgg act gca gtt gtg tgg gcg ctg ttc atg 1219 Thr Tyr Leu Phe Gly Ile Trp Thr Ala Val Val Trp Ala Leu Phe Met         360 365 370 tct atc cct gcg ctg aat cca ttc atc gaa tgg gcg ccg ctg cac agc 1267 Ser Ile Pro Ala Leu Asn Pro Phe Ile Glu Trp Ala Pro Leu His Ser     375 380 385 atg tct ttg ggt tgg gtt gtc cca gtt ctc gtg gcc tct gcc atc ggt 1315 Met Ser Leu Gly Trp Val Val Pro Val Leu Val Ala Ser Ala Ile Gly 390 395 400 405 ttg gct att gat tgg aac aag aaa ggt gcc cag tct gtt gca aag aag 1363 Leu Ala Ile Asp Trp Asn Lys Lys Gly Ala Gln Ser Val Ala Lys Lys                 410 415 420 gaa tcc att tcc gtc taatcgctaa ttgcgaggag tct 1401 Glu Ser Ile Ser Val             425 <210> 424 <211> 426 <212> PRT <213> Corynebacterium glutamicum <400> 424 Met Ser Lys Lys Ser Val Leu Ile Thr Ser Leu Met Leu Phe Ser Met   1 5 10 15 Phe Phe Gly Ala Gly Asn Leu Ile Phe Pro Pro Met Leu Gly Leu Ser              20 25 30 Ala Gly Thr Asn Tyr Leu Pro Ala Ile Leu Gly Phe Leu Ala Thr Ser          35 40 45 Val Leu Leu Pro Val Leu Ala Ile Ile Ala Val Val Leu Ser Gly Glu      50 55 60 Asn Val Lys Asp Met Ala Ser Arg Gly Gly Lys Ile Phe Gly Leu Val  65 70 75 80 Phe Pro Ile Ala Ala Tyr Leu Ser Ile Gly Ala Phe Tyr Ala Leu Pro                  85 90 95 Arg Thr Gly Ala Val Ser Tyr Ser Thr Ala Val Gly Val Asp Asn Ala             100 105 110 Leu Tyr Ser Gly Leu Phe Asn Phe Val Phe Phe Ala Val Ala Leu Ala         115 120 125 Leu Ser Trp Asn Pro Asn Gly Ile Ala Asp Lys Leu Gly Lys Trp Leu     130 135 140 Thr Pro Ala Leu Leu Thr Leu Ile Val Val Leu Val Val Leu Ser Val 145 150 155 160 Ala Lys Leu Asp Gly Thr Pro Gly Glu Pro Ser Ser Ala Tyr Ala Gln                 165 170 175 Gln Pro Ala Gly Ala Gly Leu Leu Glu Gly Tyr Met Thr Met Asp Ala             180 185 190 Ile Ala Ala Leu Ala Phe Gly Ile Val Val Ile Ser Ala Phe Lys Tyr         195 200 205 Gln Lys Val Asn Lys Val Arg Thr Ala Thr Val Val Ser Ala Phe Ile     210 215 220 Ala Gly Ile Leu Leu Ala Leu Val Tyr Leu Gly Leu Gly Ser Ile Gly 225 230 235 240 Gln Val Val Asn Gly Glu Phe Ala Asp Gly Thr Ala Ile Leu Asn Tyr                 245 250 255 Ala Ala Leu Ser Thr Met Gly Gln Ala Gly Arg Ile Met Phe Val Ala             260 265 270 Ile Leu Ile Leu Ala Cys Met Thr Thr Ala Val Gly Leu Ile Ser Ala         275 280 285 Thr Ser Glu Phe Phe Asn Ser Leu Leu Pro Gly Val Lys Tyr His Val     290 295 300 Trp Ala Thr Val Phe Ala Leu Ile Ser Phe Gly Val Ala Thr Met Gly 305 310 315 320 Leu Asp Thr Val Leu Ala Val Ala Ala Pro Val Ile Ser Phe Ile Tyr                 325 330 335 Pro Ser Ala Ile Thr Leu Val Phe Leu Ser Leu Ile Glu Pro Leu Leu             340 345 350 Phe Arg Leu Lys Trp Thr Tyr Leu Phe Gly Ile Trp Thr Ala Val Val         355 360 365 Trp Ala Leu Phe Met Ser Ile Pro Ala Leu Asn Pro Phe Ile Glu Trp     370 375 380 Ala Pro Leu His Ser Met Ser Leu Gly Trp Val Val Pro Val Leu Val 385 390 395 400 Ala Ser Ala Ile Gly Leu Ala Ile Asp Trp Asn Lys Lys Gly Ala Gln                 405 410 415 Ser Val Ala Lys Lys Glu Ser Ile Ser Val             420 425 <210> 425 <211> 1461 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (1438) <223> RXA00623 <400> 425 tttaagcttc gtcggcaacg atcacaccac gttaaatttc gaccatcaat gacggtggcc 60 gttttttggc gaatccccaa aaaggtcgaa gaggaagttc atg gat tca aac aca 115                                             Met Asp Ser Asn Thr                                               1 5 gaa tct tca agt gtt gag gtc aaa aac gaa cac att aaa gtt caa aag 163 Glu Ser Ser Ser Val Glu Val Lys Asn Glu His Ile Lys Val Gln Lys                  10 15 20 ccg ccg aag aag gac cgc act cac tgg ctc tac att gcg gtc att atc 211 Pro Pro Lys Lys Asp Arg Thr His Trp Leu Tyr Ile Ala Val Ile Ile              25 30 35 gca ttg att ggc ggt att acc cta ggc ctg att tca ccg gag ttg ggc 259 Ala Leu Ile Gly Gly Ile Thr Leu Gly Leu Ile Ser Pro Glu Leu Gly          40 45 50 aaa gaa ttc aag att ttg ggc acc atg ttt gtg tcc ttg atc aag atg 307 Lys Glu Phe Lys Ile Leu Gly Thr Met Phe Val Ser Leu Ile Lys Met      55 60 65 att atc gct cca gtt att ttc tgc acc atc gtc atc gga atc ggt tca 355 Ile Ile Ala Pro Val Ile Phe Cys Thr Ile Val Ile Gly Ile Gly Ser  70 75 80 85 gtc aag gca gcg gca aca gtc gga cgc gct ggt ggc atc gcc ctt gcg 403 Val Lys Ala Ala Ala Thr Val Gly Arg Ala Gly Gly Ile Ala Leu Ala                  90 95 100 tac ttc atc acg atg tcc aca ttc gca ctc gca gtt ggc ctg cta gtc 451 Tyr Phe Ile Thr Met Ser Thr Phe Ala Leu Ala Val Gly Leu Leu Val             105 110 115 ggt aac ttc atc cag cca ggt agc gga ctg aac atc tca gtt gat gaa 499 Gly Asn Phe Ile Gln Pro Gly Ser Gly Leu Asn Ile Ser Val Asp Glu         120 125 130 gaa tct tca ttc gca tcc aca gag agc agc cct gaa gga ctc ttg gga 547 Glu Ser Ser Phe Ala Ser Thr Glu Ser Ser Pro Glu Gly Leu Leu Gly     135 140 145 ttc atc cac tcg atc atc cct gaa acg ttc ttc tct gca ttt act gat 595 Phe Ile His Ser Ile Ile Pro Glu Thr Phe Phe Ser Ala Phe Thr Asp 150 155 160 165 ggt tcg gtg ctg cag gta ctg ttc atc gcc atc ctc gtg ggc ttt gca 643 Gly Ser Val Leu Gln Val Leu Phe Ile Ala Ile Leu Val Gly Phe Ala                 170 175 180 gct cag tcg atg ggt gaa aag gga cag ccc atc ctt gat ttc gta tcc 691 Ala Gln Ser Met Gly Glu Lys Gly Gln Pro Ile Leu Asp Phe Val Ser             185 190 195 cat ctg cag aag ctc atc ttc aag att ttg aac tgg att ctg tgg ctc 739 His Leu Gln Lys Leu Ile Phe Lys Ile Leu Asn Trp Ile Leu Trp Leu         200 205 210 gcc cca gtc ggt gca ttc ggt gca atg gcc ggc gtc gtt ggc gaa aca 787 Ala Pro Val Gly Ala Phe Gly Ala Met Ala Gly Val Val Gly Glu Thr     215 220 225 ggc ttt gat gcc gtt gtt cag ctc ggt att ttg atc ctc gcc ttt tac 835 Gly Phe Asp Ala Val Val Gln Leu Gly Ile Leu Ile Leu Ala Phe Tyr 230 235 240 245 gtc acc tgc gtg atc ttc atc ttt ggc gtg ctg ggc gcc gta ctg aag 883 Val Thr Cys Val Ile Phe Ile Phe Gly Val Leu Gly Ala Val Leu Lys                 250 255 260 gtg ttc acc ggc gtg aat atc ttc aag ctg gtc aag tac ctt gcc aag 931 Val Phe Thr Gly Val Asn Ile Phe Lys Leu Val Lys Tyr Leu Ala Lys             265 270 275 gaa ttc ctg ctg atc ttt gct acc tca tcc tct gaa tct gcc ttg cca 979 Glu Phe Leu Leu Ile Phe Ala Thr Ser Ser Ser Glu Ser Ala Leu Pro         280 285 290 aac ctc atg cgc aag atg gaa cac atc ggt gtg gct aaa cca acc gtc 1027 Asn Leu Met Arg Lys Met Glu His Ile Gly Val Ala Lys Pro Thr Val     295 300 305 gga atc gtg gtc cca acc ggc tat tcc ttc aac ttg gac ggc acc gca 1075 Gly Ile Val Val Pro Thr Gly Tyr Ser Phe Asn Leu Asp Gly Thr Ala 310 315 320 325 att tac ctc acc atg gca tct atc ttc att gcc gac gcg atg aat atg 1123 Ile Tyr Leu Thr Met Ala Ser Ile Phe Ile Ala Asp Ala Met Asn Met                 330 335 340 ccg atg agc ctc ggc gag cag gtc ggt ctg ctt gtc ttc atg atc atc 1171 Pro Met Ser Leu Gly Glu Gln Val Gly Leu Leu Val Phe Met Ile Ile             345 350 355 gca tcc aag ggc gct gct ggt gtc tcg ggt gcc ggt att gca acg ttg 1219 Ala Ser Lys Gly Ala Ala Gly Val Ser Gly Ala Gly Ile Ala Thr Leu         360 365 370 gct gcc gga ttg tct tca cac cgc cca gaa ctt ctg cac ggc gtt gac 1267 Ala Ala Gly Leu Ser Ser His Arg Pro Glu Leu Leu His Gly Val Asp     375 380 385 gtg att gtg ggc atc gat aaa ttc atg tct gaa gcc cgc gca cta acc 1315 Val Ile Val Gly Ile Asp Lys Phe Met Ser Glu Ala Arg Ala Leu Thr 390 395 400 405 aac ttc gcc gga aac tcc gtg gca aca ctg ctg gtc ggc aag tgg act 1363 Asn Phe Ala Gly Asn Ser Val Ala Thr Leu Leu Val Gly Lys Trp Thr                 410 415 420 ggc acc gtg gac atg aac caa gtc cat gac gtt ttg aat gga aaa tct 1411 Gly Thr Val Asp Met Asn Gln Val His Asp Val Leu Asn Gly Lys Ser             425 430 435 cca ttt gtg gag tta gaa gaa gac cac tagttttcaa caggacgaca 1458 Pro Phe Val Glu Leu Glu Glu Asp His         440 445 acg 1461 <210> 426 <211> 446 <212> PRT <213> Corynebacterium glutamicum <400> 426 Met Asp Ser Asn Thr Glu Ser Ser Ser Val Glu Val Lys Asn Glu His   1 5 10 15 Ile Lys Val Gln Lys Pro Pro Lys Lys Asp Arg Thr His Trp Leu Tyr              20 25 30 Ile Ala Val Ile Ile Ala Leu Ile Gly Gly Ile Thr Leu Gly Leu Ile          35 40 45 Ser Pro Glu Leu Gly Lys Glu Phe Lys Ile Leu Gly Thr Met Phe Val      50 55 60 Ser Leu Ile Lys Met Ile Ile Ala Pro Val Ile Phe Cys Thr Ile Val  65 70 75 80 Ile Gly Ile Gly Ser Val Lys Ala Ala Ala Thr Val Gly Arg Ala Gly                  85 90 95 Gly Ile Ala Leu Ala Tyr Phe Ile Thr Met Ser Thr Phe Ala Leu Ala             100 105 110 Val Gly Leu Leu Val Gly Asn Phe Ile Gln Pro Gly Ser Gly Leu Asn         115 120 125 Ile Ser Val Asp Glu Glu Ser Ser Phe Ala Ser Thr Glu Ser Ser Pro     130 135 140 Glu Gly Leu Leu Gly Phe Ile His Ser Ile Ile Pro Glu Thr Phe Phe 145 150 155 160 Ser Ala Phe Thr Asp Gly Ser Val Leu Gln Val Leu Phe Ile Ala Ile                 165 170 175 Leu Val Gly Phe Ala Ala Gln Ser Met Gly Glu Lys Gly Gln Pro Ile             180 185 190 Leu Asp Phe Val Ser His Leu Gln Lys Leu Ile Phe Lys Ile Leu Asn         195 200 205 Trp Ile Leu Trp Leu Ala Pro Val Gly Ala Phe Gly Ala Met Ala Gly     210 215 220 Val Val Gly Glu Thr Gly Phe Asp Ala Val Val Gln Leu Gly Ile Leu 225 230 235 240 Ile Leu Ala Phe Tyr Val Thr Cys Val Ile Phe Ile Phe Gly Val Leu                 245 250 255 Gly Ala Val Leu Lys Val Phe Thr Gly Val Asn Ile Phe Lys Leu Val             260 265 270 Lys Tyr Leu Ala Lys Glu Phe Leu Leu Ile Phe Ala Thr Ser Ser Ser         275 280 285 Glu Ser Ala Leu Pro Asn Leu Met Arg Lys Met Glu His Ile Gly Val     290 295 300 Ala Lys Pro Thr Val Gly Ile Val Val Pro Thr Gly Tyr Ser Phe Asn 305 310 315 320 Leu Asp Gly Thr Ala Ile Tyr Leu Thr Met Ala Ser Ile Phe Ile Ala                 325 330 335 Asp Ala Met Asn Met Pro Met Ser Leu Gly Glu Gln Val Gly Leu Leu             340 345 350 Val Phe Met Ile Ile Ala Ser Lys Gly Ala Ala Gly Val Ser Gly Ala         355 360 365 Gly Ile Ala Thr Leu Ala Ala Gly Leu Ser Ser His Arg Pro Glu Leu     370 375 380 Leu His Gly Val Asp Val Ile Val Gly Ile Asp Lys Phe Met Ser Glu 385 390 395 400 Ala Arg Ala Leu Thr Asn Phe Ala Gly Asn Ser Val Ala Thr Leu Leu                 405 410 415 Val Gly Lys Trp Thr Gly Thr Val Asp Met Asn Gln Val His Asp Val             420 425 430 Leu Asn Gly Lys Ser Pro Phe Val Glu Leu Glu Glu Asp His         435 440 445 <210> 427 <211> 620 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (55) .. (597) <223> RXA01584 <400> 427 ccaccccctt ccccgctacg cgccataccg gcttgggcgg gcatcggatc acta gtg 57                                                             Val                                                               One gtg ttt ttg ggc gca ctt ctc ggc gcc gta atc atg ggc ggg ttt tat 105 Val Phe Leu Gly Ala Leu Leu Gly Ala Val Ile Met Gly Gly Phe Tyr               5 10 15 cca gca ttc att caa gcc gga tcc aca gtg ttc ggc ggc ggc cac gtg 153 Pro Ala Phe Ile Gln Ala Gly Ser Thr Val Phe Gly Gly Gly His Val          20 25 30 gtt ttg cca ctg ctg gaa aag ctc gtt gtt gcg ccc ggt ttt att aaa 201 Val Leu Pro Leu Leu Glu Lys Leu Val Val Ala Pro Gly Phe Ile Lys      35 40 45 gaa acc gac ttc cta tcc ggc tac tcc gca gcg cag gca gtg cct ggc 249 Glu Thr Asp Phe Leu Ser Gly Tyr Ser Ala Ala Gln Ala Val Pro Gly  50 55 60 65 ccc atg ttc agc ttc gcc agc tac ctc ggc gca atc tac ggt ggc atc 297 Pro Met Phe Ser Phe Ala Ser Tyr Leu Gly Ala Ile Tyr Gly Gly Ile                  70 75 80 ggt ggt gca gtg ctg gcc agc ctg gcg atc ttc ttc ccc gcc gca ctc 345 Gly Gly Ala Val Leu Ala Ser Leu Ala Ile Phe Phe Pro Ala Ala Leu              85 90 95 ttg agc atc agc gga atg tac ttt tgg gga cgc tgg cga aaa gca ccg 393 Leu Ser Ile Ser Gly Met Tyr Phe Trp Gly Arg Trp Arg Lys Ala Pro         100 105 110 cgc atc caa gca gca gtc acc ggc atc aac gcc ggt gtg gtg ggg ctt 441 Arg Ile Gln Ala Ala Val Thr Gly Ile Asn Ala Gly Val Val Gly Leu     115 120 125 ttg ggc gca gcg ctc tac gat ccc gta ttc acc cac ggc atc acc agc 489 Leu Gly Ala Ala Leu Tyr Asp Pro Val Phe Thr His Gly Ile Thr Ser 130 135 140 145 gtt tcc gca tta gct atc gca acg gtg tgt tgg ctg ggg cta gcc cac 537 Val Ser Ala Leu Ala Ile Ala Thr Val Cys Trp Leu Gly Leu Ala His                 150 155 160 tgg aaa att ccg ccg tgg gcc atc gcc gcg ggt gcg gcc ctt gca ggc 585 Trp Lys Ile Pro Pro Trp Ala Ile Ala Ala Gly Ala Ala Leu Ala Gly             165 170 175 tgg gtc ttg ctt tagaaaacgc tcagacccaa acc 620 Trp Val Leu Leu         180 <210> 428 <211> 181 <212> PRT <213> Corynebacterium glutamicum <400> 428 Val Val Phe Leu Gly Ala Leu Leu Gly Ala Val Ile Met Gly Gly Phe   1 5 10 15 Tyr Pro Ala Phe Ile Gln Ala Gly Ser Thr Val Phe Gly Gly Gly His              20 25 30 Val Val Leu Pro Leu Leu Glu Lys Leu Val Val Ala Pro Gly Phe Ile          35 40 45 Lys Glu Thr Asp Phe Leu Ser Gly Tyr Ser Ala Ala Gln Ala Val Pro      50 55 60 Gly Pro Met Phe Ser Phe Ala Ser Tyr Leu Gly Ala Ile Tyr Gly Gly  65 70 75 80 Ile Gly Gly Ala Val Leu Ala Ser Leu Ala Ile Phe Phe Pro Ala Ala                  85 90 95 Leu Leu Ser Ile Ser Gly Met Tyr Phe Trp Gly Arg Trp Arg Lys Ala             100 105 110 Pro Arg Ile Gln Ala Ala Val Thr Gly Ile Asn Ala Gly Val Val Gly         115 120 125 Leu Leu Gly Ala Ala Leu Tyr Asp Pro Val Phe Thr His Gly Ile Thr     130 135 140 Ser Val Ser Ala Leu Ala Ile Ala Thr Val Cys Trp Leu Gly Leu Ala 145 150 155 160 His Trp Lys Ile Pro Pro Trp Ala Ile Ala Ala Gly Ala Ala Leu Ala                 165 170 175 Gly Trp Val Leu Leu             180 <210> 429 <211> 813 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (790) <223> RXA00852 <400> 429 agatcaccgt catggtcata atcgccgctg gagttcatgc agcattccct gacatccgta 60 agaaatagtt ccaacccact tttcctcaga attgcagttc atg ccc gag atc att 115                                             Met Pro Glu Ile Ile                                               1 5 ttt gac aac act gaa gta cgc tac gat gac tcg ctc att tta gag ccc 163 Phe Asp Asn Thr Glu Val Arg Tyr Asp Asp Ser Leu Ile Leu Glu Pro                  10 15 20 cta tcg tta aaa ctg aca gaa caa cgc att ggc atc atc ggg gct aac 211 Leu Ser Leu Lys Leu Thr Glu Gln Arg Ile Gly Ile Ile Gly Ala Asn              25 30 35 ggc ggt gga aaa tcc acg ctc atc aga atg atc aat ggt ctc ggc gaa 259 Gly Gly Gly Lys Ser Thr Leu Ile Arg Met Ile Asn Gly Leu Gly Glu          40 45 50 cca acc aca ggg cgt gtt cta gtt gat ggc ctt gac gtc tcg cat tcc 307 Pro Thr Thr Gly Arg Val Leu Val Asp Gly Leu Asp Val Ser His Ser      55 60 65 gga cgg gaa gtt cgc aag aag gtt gga ttt gtc ttc tct gac gct gaa 355 Gly Arg Glu Val Arg Lys Lys Val Gly Phe Val Phe Ser Asp Ala Glu  70 75 80 85 aac cag atc gtg atg cca act gtg cgt gag gat att gcc ttc tcg ctt 403 Asn Gln Ile Val Met Pro Thr Val Arg Glu Asp Ile Ala Phe Ser Leu                  90 95 100 cgc cgg cac aaa atg cca cgc gct gaa aag gcg caa cgt gtc gac gag 451 Arg Arg His Lys Met Pro Arg Ala Glu Lys Ala Gln Arg Val Asp Glu             105 110 115 atg atg gcg cga ttc aac ttg agc gag cat gca gat caa tca ccg cac 499 Met Met Ala Arg Phe Asn Leu Ser Glu His Ala Asp Gln Ser Pro His         120 125 130 acc cta tcc ggt ggt caa aag cag ttg tta gcg ctg gct gca gta ctg 547 Thr Leu Ser Gly Gly Gln Lys Gln Leu Leu Ala Leu Ala Ala Val Leu     135 140 145 att ttg gag cca gaa gtg atc atc gct gat gag ccc act acc ctg ctg 595 Ile Leu Glu Pro Glu Val Ile Ile Ala Asp Glu Pro Thr Thr Leu Leu 150 155 160 165 gat ctg cgc aat agg ctg atg atc aaa gac gtg ttc aat aaa ctc gag 643 Asp Leu Arg Asn Arg Leu Met Ile Lys Asp Val Phe Asn Lys Leu Glu                 170 175 180 cag caa tta atc gtt gtc agc cat gat tta gat ttc ctc agc gat ttt 691 Gln Gln Leu Ile Val Val Ser His Asp Leu Asp Phe Leu Ser Asp Phe             185 190 195 gag cgg gtc att tgc atc aat gat cat aaa atc gct gct gat ggc cct 739 Glu Arg Val Ile Cys Ile Asn Asp His Lys Ile Ala Ala Asp Gly Pro         200 205 210 ccg caa aag tcc att gac ctg tac gta tcg ctt atg gcg gaa cct gcg 787 Pro Gln Lys Ser Ile Asp Leu Tyr Val Ser Leu Met Ala Glu Pro Ala     215 220 225 aaa tgaacagtat tcctttaggt ttt 813 Lys 230 <210> 430 <211> 230 <212> PRT <213> Corynebacterium glutamicum <400> 430 Met Pro Glu Ile Ile Phe Asp Asn Thr Glu Val Arg Tyr Asp Asp Ser   1 5 10 15 Leu Ile Leu Glu Pro Leu Ser Leu Lys Leu Thr Glu Gln Arg Ile Gly              20 25 30 Ile Ile Gly Ala Asn Gly Gly Gly Lys Ser Thr Leu Ile Arg Met Ile          35 40 45 Asn Gly Leu Gly Glu Pro Thr Thr Gly Arg Val Leu Val Asp Gly Leu      50 55 60 Asp Val Ser His Ser Gly Arg Glu Val Arg Lys Lys Val Gly Phe Val  65 70 75 80 Phe Ser Asp Ala Glu Asn Gln Ile Val Met Pro Thr Val Arg Glu Asp                  85 90 95 Ile Ala Phe Ser Leu Arg Arg His Lys Met Pro Arg Ala Glu Lys Ala             100 105 110 Gln Arg Val Asp Glu Met Met Ala Arg Phe Asn Leu Ser Glu His Ala         115 120 125 Asp Gln Ser Pro His Thr Leu Ser Gly Gly Gln Lys Gln Leu Leu Ala     130 135 140 Leu Ala Ala Val Leu Ile Leu Glu Pro Glu Val Ile Ile Ala Asp Glu 145 150 155 160 Pro Thr Thr Leu Leu Asp Leu Arg Asn Arg Leu Met Ile Lys Asp Val                 165 170 175 Phe Asn Lys Leu Glu Gln Gln Leu Ile Val Val Ser His Asp Leu Asp             180 185 190 Phe Leu Ser Asp Phe Glu Arg Val Ile Cys Ile Asn Asp His Lys Ile         195 200 205 Ala Ala Asp Gly Pro Pro Gln Lys Ser Ile Asp Leu Tyr Val Ser Leu     210 215 220 Met Ala Glu Pro Ala Lys 225 230 <210> 431 <211> 1269 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1246) <223> RXA00690 <400> 431 atggatcatt ggactcacac tggctgtcat ttccttggtt tcagcgtctg ctgtggcggc 60 gtgggcgatt cgtcgttcag aggtccaggg ttaaagcttc gtg aaa tgg att gag 115                                             Val Lys Trp Ile Glu                                               1 5 cga tat gtg ctg tcc cgg cgg atg gtt cat ccc tgg gcg tgg tgg gtg 163 Arg Tyr Val Leu Ser Arg Arg Met Val His Pro Trp Ala Trp Trp Val                  10 15 20 tgg gcg ttg ggt att gct ggt tgt gcc agc atg acc aac aat cct tat 211 Trp Ala Leu Gly Ile Ala Gly Cys Ala Ser Met Thr Asn Asn Pro Tyr              25 30 35 att ttg gcg ctc act ttt gcc acg ttg tgt ttt gtg gtg ttt aac cgt 259 Ile Leu Ala Leu Thr Phe Ala Thr Leu Cys Phe Val Val Phe Asn Arg          40 45 50 cgt ggg tca tcg ccg tgg tcg cgt gct ttc ccg atc tat ttg atg atc 307 Arg Gly Ser Ser Pro Trp Ser Arg Ala Phe Pro Ile Tyr Leu Met Ile      55 60 65 gcg ggt tgg ctc gtg gtg tac cgg ttg gtc atg cac att gtg gtg gga 355 Ala Gly Trp Leu Val Val Tyr Arg Leu Val Met His Ile Val Val Gly  70 75 80 85 gca aaa att ggc acc att gaa ctg ttt cgg atc ccg ccg gtg cag ttg 403 Ala Lys Ile Gly Thr Ile Glu Leu Phe Arg Ile Pro Pro Val Gln Leu                  90 95 100 ccg gaa tgg gct gcg ggt atc cac gtg ttt ggc acg gtg tat ctc gag 451 Pro Glu Trp Ala Ala Gly Ile His Val Phe Gly Thr Val Tyr Leu Glu             105 110 115 ggt ctg atc atc gcg acg acg caa ggc tta acg ctt gga acg atg atc 499 Gly Leu Ile Ile Ala Thr Thr Gln Gly Leu Thr Leu Gly Thr Met Ile         120 125 130 gtg gcg gtg ggt gct gcg aac tct ttg gcg gat ccc aag aag ctg ctc 547 Val Ala Val Gly Ala Ala Asn Ser Leu Ala Asp Pro Lys Lys Leu Leu     135 140 145 aaa tcg ttg cct ggc gca ttg ggc gaa ctg gga act gcg gtg gtc atc 595 Lys Ser Leu Pro Gly Ala Leu Gly Glu Leu Gly Thr Ala Val Val Ile 150 155 160 165 ggt att tcc att gca cct cag atg gct gag tcg gcg ttc cgc att aat 643 Gly Ile Ser Ile Ala Pro Gln Met Ala Glu Ser Ala Phe Arg Ile Asn                 170 175 180 cgt gca cga acc ttg cgt ggt gat gat gcc aaa ggt gtt cgt ggt ttc 691 Arg Ala Arg Thr Leu Arg Gly Asp Asp Ala Lys Gly Val Arg Gly Phe             185 190 195 gcg cgg att ttg atg ccg gtt ttc cag gac act ttg gat agg tct ttg 739 Ala Arg Ile Leu Met Pro Val Phe Gln Asp Thr Leu Asp Arg Ser Leu         200 205 210 gcc ctg gct aat tcc atg gat gcc cgt ggt tat ggc agg cag gct cat 787 Ala Leu Ala Asn Ser Met Asp Ala Arg Gly Tyr Gly Arg Gln Ala His     215 220 225 gta tcc aaa ttc caa cag cgt gtg acc tct att ttt ggt gca ttc gga 835 Val Ser Lys Phe Gln Gln Arg Val Thr Ser Ile Phe Gly Ala Phe Gly 230 235 240 245 ata ctc ggc gtg acc gtt ggt ctg ttt gtg gtc tta gat gca tca tca 883 Ile Leu Gly Val Thr Val Gly Leu Phe Val Val Leu Asp Ala Ser Ser                 250 255 260 ccg atg ttc gtt gcc gtt ccg gtg ttt att acc ggc gtg ggc ttc ttg 931 Pro Met Phe Val Ala Val Pro Val Phe Ile Thr Gly Val Gly Phe Leu             265 270 275 atc att tcg ttg gtc gtt gct tca cat aga aaa aca tcc acc act ttt 979 Ile Ile Ser Leu Val Val Ala Ser His Arg Lys Thr Ser Thr Thr Phe         280 285 290 gat cag ttg cct tgg ggt gct gcg gaa tgg ctt gtg tgc atc aca ggt 1027 Asp Gln Leu Pro Trp Gly Ala Ala Glu Trp Leu Val Cys Ile Thr Gly     295 300 305 gtg att ccg ctg ctc atg gct gcg ctg aca cga tac ctt gat cca ggt 1075 Val Ile Pro Leu Leu Met Ala Ala Leu Thr Arg Tyr Leu Asp Pro Gly 310 315 320 325 tcc atg atc acc acc tgg gtt cct ttg cat atg cca gac acc gtt ccg 1123 Ser Met Ile Thr Thr Trp Val Pro Leu His Met Pro Asp Thr Val Pro                 330 335 340 ttg ctc gtt gtg gca gga ctt gtt gtg gcg acg atg cca gga ttc ttg 1171 Leu Leu Val Val Ala Gly Leu Val Val Ala Thr Met Pro Gly Phe Leu             345 350 355 acg ccc cgc ttg ccg aag aac aaa gtg agg gtc aag cgt cga aaa gca 1219 Thr Pro Arg Leu Pro Lys Asn Lys Val Arg Val Lys Arg Arg Lys Ala         360 365 370 ata aat agc cca gaa agg gcc gaa gtt taatgagtgc tccttttagc 1266 Ile Asn Ser Pro Glu Arg Ala Glu Val     375 380 gcg 1269 <210> 432 <211> 382 <212> PRT <213> Corynebacterium glutamicum <400> 432 Val Lys Trp Ile Glu Arg Tyr Val Leu Ser Arg Arg Met Val His Pro   1 5 10 15 Trp Ala Trp Trp Val Trp Ala Leu Gly Ile Ala Gly Cys Ala Ser Met              20 25 30 Thr Asn Asn Pro Tyr Ile Leu Ala Leu Thr Phe Ala Thr Leu Cys Phe          35 40 45 Val Val Phe Asn Arg Arg Gly Ser Ser Pro Trp Ser Arg Ala Phe Pro      50 55 60 Ile Tyr Leu Met Ile Ala Gly Trp Leu Val Val Tyr Arg Leu Val Met  65 70 75 80 His Ile Val Val Gly Ala Lys Ile Gly Thr Ile Glu Leu Phe Arg Ile                  85 90 95 Pro Pro Val Gln Leu Pro Glu Trp Ala Ala Gly Ile His Val Phe Gly             100 105 110 Thr Val Tyr Leu Glu Gly Leu Ile Ile Ala Thr Thr Thr Gln Gly Leu Thr         115 120 125 Leu Gly Thr Met Ile Val Ala Val Gly Ala Ala Asn Ser Leu Ala Asp     130 135 140 Pro Lys Lys Leu Leu Lys Ser Leu Pro Gly Ala Leu Gly Glu Leu Gly 145 150 155 160 Thr Ala Val Val Ile Gly Ile Ser Ile Ala Pro Gln Met Ala Glu Ser                 165 170 175 Ala Phe Arg Ile Asn Arg Ala Arg Thr Leu Arg Gly Asp Asp Ala Lys             180 185 190 Gly Val Arg Gly Phe Ala Arg Ile Leu Met Pro Val Phe Gln Asp Thr         195 200 205 Leu Asp Arg Ser Leu Ala Leu Ala Asn Ser Met Asp Ala Arg Gly Tyr     210 215 220 Gly Arg Gln Ala His Val Ser Lys Phe Gln Gln Arg Val Thr Ser Ile 225 230 235 240 Phe Gly Ala Phe Gly Ile Leu Gly Val Thr Val Gly Leu Phe Val Val                 245 250 255 Leu Asp Ala Ser Ser Pro Met Phe Val Ala Val Pro Val Phe Ile Thr             260 265 270 Gly Val Gly Phe Leu Ile Ile Ser Leu Val Val Ala Ser His Arg Lys         275 280 285 Thr Ser Thr Thr Phe Asp Gln Leu Pro Trp Gly Ala Ala Glu Trp Leu     290 295 300 Val Cys Ile Thr Gly Val Ile Pro Leu Leu Met Ala Ala Leu Thr Arg 305 310 315 320 Tyr Leu Asp Pro Gly Ser Met Ile Thr Thr Trp Val Pro Leu His Met                 325 330 335 Pro Asp Thr Val Pro Leu Leu Val Val Ala Gly Leu Val Val Ala Thr             340 345 350 Met Pro Gly Phe Leu Thr Pro Arg Leu Pro Lys Asn Lys Val Arg Val         355 360 365 Lys Arg Arg Lys Ala Ile Asn Ser Pro Glu Arg Ala Glu Val     370 375 380 <210> 433 <211> 876 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (101) .. (853) <223> RXA00827 <400> 433 tgcgtgaatt aacagacaac ggaatcagca ttgtgtcagt aacccatgat cctgatttca 60 tcgcagcgct gggcgatcac cacattgagg tgagcgcgaa gtg aac ctg ctg atc 115                                             Val Asn Leu Leu Ile                                               1 5 aaa att aat ccc gtc acc cgc atc atc gcg ttg atg gta ctg acc acg 163 Lys Ile Asn Pro Val Thr Arg Ile Ile Ala Leu Met Val Leu Thr Thr                  10 15 20 ccg ttg ctg ctg agt ttg gat gtg atg tcg gca gcg atc gcg ctg gtg 211 Pro Leu Leu Leu Ser Leu Asp Val Met Ser Ala Ala Ile Ala Leu Val              25 30 35 gca acc att att ctg gca cca ttt gcc ggc gtg acc tgg aag atg ctg 259 Ala Thr Ile Ile Leu Ala Pro Phe Ala Gly Val Thr Trp Lys Met Leu          40 45 50 ctg aaa cgt ggc tgg atg ctg ttc ctc atg gca ccg gtg gct gca tta 307 Leu Lys Arg Gly Trp Met Leu Phe Leu Met Ala Pro Val Ala Ala Leu      55 60 65 tcc atg gcg ctt tat ggc agg ccg gat gga aaa gag tac ttt agc ttc 355 Ser Met Ala Leu Tyr Gly Arg Pro Asp Gly Lys Glu Tyr Phe Ser Phe  70 75 80 85 ctg ctc att cac gtc act gat aat tca ctg gct ttg gct gct gcc att 403 Leu Leu Ile His Val Thr Asp Asn Ser Leu Ala Leu Ala Ala Ala Ile                  90 95 100 ggg ctg cgt gtt ctg gcg att ggt ctg ccc gtt gtg gtg ctg att gct 451 Gly Leu Arg Val Leu Ala Ile Gly Leu Pro Val Val Val Leu Ile Ala             105 110 115 cgc att gat ccc acc gac ctg ggc gat ggt ttg gcg cag ctg ctc aaa 499 Arg Ile Asp Pro Thr Asp Leu Gly Asp Gly Leu Ala Gln Leu Leu Lys         120 125 130 ctg cct gaa agg ttt gtc atc ggt gct gtg gca gga agc cga ctg atg 547 Leu Pro Glu Arg Phe Val Ile Gly Ala Val Ala Gly Ser Arg Leu Met     135 140 145 acg ctt ttt cgg gaa gat tgg tac tcc atg tcc agg gca agg cgt gcc 595 Thr Leu Phe Arg Glu Asp Trp Tyr Ser Met Ser Arg Ala Arg Arg Ala 150 155 160 165 cgc gga att gct gat cag ggc aag atc aag cac ttt ttc acc atg act 643 Arg Gly Ile Ala Asp Gln Gly Lys Ile Lys His Phe Phe Thr Met Thr                 170 175 180 ttt ggt ttg ttg gtg ctc tcg ctt cgc cgt gga tcc aag ctt gca acg 691 Phe Gly Leu Leu Val Leu Ser Leu Arg Arg Gly Ser Lys Leu Ala Thr             185 190 195 gcg atg gaa gca cgc ggt ttt ggt cgc acg act ggc cgc acc tgg gca 739 Ala Met Glu Ala Arg Gly Phe Gly Arg Thr Thr Gly Arg Thr Trp Ala         200 205 210 agg gaa tcc acc gtc ggc gcg cgc gat ctg gtg ctc atc ttg gtg tgt 787 Arg Glu Ser Thr Val Gly Ala Arg Asp Leu Val Leu Ile Leu Val Cys     215 220 225 gct gcc att tcc gcg atc gct cta acc gtg tcc att cag act ggt ttc 835 Ala Ala Ile Ser Ala Ile Ala Leu Thr Val Ser Ile Gln Thr Gly Phe 230 235 240 245 ttt aag ttc ttg ggc aca tgatcacagt tttaattgat gga 876 Phe Lys Phe Leu Gly Thr                 250 <210> 434 <211> 251 <212> PRT <213> Corynebacterium glutamicum <400> 434 Val Asn Leu Leu Ile Lys Ile Asn Pro Val Thr Arg Ile Ile Ala Leu   1 5 10 15 Met Val Leu Thr Thr Pro Leu Leu Leu Ser Leu Asp Val Met Ser Ala              20 25 30 Ala Ile Ala Leu Val Ala Thr Ile Ile Leu Ala Pro Phe Ala Gly Val          35 40 45 Thr Trp Lys Met Leu Leu Lys Arg Gly Trp Met Leu Phe Leu Met Ala      50 55 60 Pro Val Ala Ala Leu Ser Met Ala Leu Tyr Gly Arg Pro Asp Gly Lys  65 70 75 80 Glu Tyr Phe Ser Phe Leu Leu Ile His Val Thr Asp Asn Ser Leu Ala                  85 90 95 Leu Ala Ala Ala Ile Gly Leu Arg Val Leu Ala Ile Gly Leu Pro Val             100 105 110 Val Val Leu Ile Ala Arg Ile Asp Pro Thr Asp Leu Gly Asp Gly Leu         115 120 125 Ala Gln Leu Leu Lys Leu Pro Glu Arg Phe Val Ile Gly Ala Val Ala     130 135 140 Gly Ser Arg Leu Met Thr Leu Phe Arg Glu Asp Trp Tyr Ser Met Ser 145 150 155 160 Arg Ala Arg Arg Ala Arg Gly Ile Ala Asp Gln Gly Lys Ile Lys His                 165 170 175 Phe Phe Thr Met Thr Phe Gly Leu Leu Val Leu Ser Leu Arg Arg Gly             180 185 190 Ser Lys Leu Ala Thr Ala Met Glu Ala Arg Gly Phe Gly Arg Thr Thr         195 200 205 Gly Arg Thr Trp Ala Arg Glu Ser Thr Val Gly Ala Arg Asp Leu Val     210 215 220 Leu Ile Leu Val Cys Ala Ala Ile Ser Ala Ile Ala Leu Thr Val Ser 225 230 235 240 Ile Gln Thr Gly Phe Phe Lys Phe Leu Gly Thr                 245 250 <210> 435 <211> 732 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (709) <223> RXA00851 <400> 435 ttgagcgggt catttgcatc aatgatcata aaatcgctgc tgatggccct ccgcaaaagt 60 ccattgacct gtacgtatcg cttatggcgg aacctgcgaa atg aac agt att cct 115                                             Met Asn Ser Ile Pro                                               1 5 tta ggt ttt tac gtc gat aag caa tct gtt gtt cat tct ttt cct gct 163 Leu Gly Phe Tyr Val Asp Lys Gln Ser Val Val His Ser Phe Pro Ala                  10 15 20 ttg tgg aaa ttc cca ctt ctg ctg ttt ttc atc atc ggc ggc tcc atc 211 Leu Trp Lys Phe Pro Leu Leu Leu Phe Phe Ile Ile Gly Gly Ser Ile              25 30 35 gcg gct tct acc ccg gtt cat ggg ttg att ttg gtg ggg att gca gtg 259 Ala Ala Ser Thr Pro Val His Gly Leu Ile Leu Val Gly Ile Ala Val          40 45 50 gtg ttt tac gtg ctg gcg aag att ccg ctg aag gtc gcg tgg gag cag 307 Val Phe Tyr Val Leu Ala Lys Ile Pro Leu Lys Val Ala Trp Glu Gln      55 60 65 ttg tgg cca gtg ctg ccg att ttg atc atg ctc ggt gcg ttt cag tgg 355 Leu Trp Pro Val Leu Pro Ile Leu Ile Met Leu Gly Ala Phe Gln Trp  70 75 80 85 tgg cag cgc ggc ttt gat ttc gcg gca acc aca gtg ctc acg ctg ttt 403 Trp Gln Arg Gly Phe Asp Phe Ala Ala Thr Thr Val Val Leu Thr Leu Phe                  90 95 100 tcc gcg gtg atg gcc gcc atg ttg ttg acg ttg acc acg cgg ttg gaa 451 Ser Ala Val Met Ala Ala Met Leu Leu Thr Leu Thr Thr Arg Leu Glu             105 110 115 gcg ctc atg aat gca gtt gag cgg atg ttg cag cct ttt gca cgt ttt 499 Ala Leu Met Asn Ala Val Glu Arg Met Leu Gln Pro Phe Ala Arg Phe         120 125 130 ggc ctg cca gta gag acg atc acc ttg gct att tct ctc acg att cgg 547 Gly Leu Pro Val Glu Thr Ile Thr Leu Ala Ile Ser Leu Thr Ile Arg     135 140 145 ctc att ccg ctg caa tta gcc acg gtg aag gaa gtc ctc gat gcc cgt 595 Leu Ile Pro Leu Gln Leu Ala Thr Val Lys Glu Val Leu Asp Ala Arg 150 155 160 165 aaa gct cgt ggt gcc ggt ttt tct atc gcc gcg ttt ggc acg cct gtg 643 Lys Ala Arg Gly Ala Gly Phe Ser Ile Ala Ala Phe Gly Thr Pro Val                 170 175 180 atc atc aga tca ata aag agg gcc cgc aat atc ggc gat gct ctt ctc 691 Ile Ile Arg Ser Ile Lys Arg Ala Arg Asn Ile Gly Asp Ala Leu Leu             185 190 195 gca cgt ggt gcc ggc gat taatttcttt caacacatag caa 732 Ala Arg Gly Ala Gly Asp         200 <210> 436 <211> 203 <212> PRT <213> Corynebacterium glutamicum <400> 436 Met Asn Ser Ile Pro Leu Gly Phe Tyr Val Asp Lys Gln Ser Val Val   1 5 10 15 His Ser Phe Pro Ala Leu Trp Lys Phe Pro Leu Leu Leu Phe Phe Ile              20 25 30 Ile Gly Gly Ser Ile Ala Ala Ser Thr Pro Val His Gly Leu Ile Leu          35 40 45 Val Gly Ile Ala Val Val Phe Tyr Val Leu Ala Lys Ile Pro Leu Lys      50 55 60 Val Ala Trp Glu Gln Leu Trp Pro Val Leu Pro Ile Leu Ile Met Leu  65 70 75 80 Gly Ala Phe Gln Trp Trp Gln Arg Gly Phe Asp Phe Ala Ala Thr Thr                  85 90 95 Val Leu Thr Leu Phe Ser Ala Val Met Ala Ala Met Leu Leu Thr Leu             100 105 110 Thr Thr Arg Leu Glu Ala Leu Met Asn Ala Val Glu Arg Met Leu Gln         115 120 125 Pro Phe Ala Arg Phe Gly Leu Pro Val Glu Thr Ile Thr Leu Ala Ile     130 135 140 Ser Leu Thr Ile Arg Leu Ile Pro Leu Gln Leu Ala Thr Val Lys Glu 145 150 155 160 Val Leu Asp Ala Arg Lys Ala Arg Gly Ala Gly Phe Ser Ile Ala Ala                 165 170 175 Phe Gly Thr Pro Val Ile Ile Arg Ser Ile Lys Arg Ala Arg Asn Ile             180 185 190 Gly Asp Ala Leu Leu Ala Arg Gly Ala Gly Asp         195 200 <210> 437 <211> 725 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (3) .. (695) <223> RXS03220 <400> 437 cc atg ggc tta agg gaa att ttg tcc agc aag tgg ctt gtg cgc atc 47    Met Gly Leu Arg Glu Ile Leu Ser Ser Lys Trp Leu Val Arg Ile      1 5 10 15 ctc ctg gta ggt atc gga ttg ggt gtc gca cag cag ctg acc ggc atc 95 Leu Leu Val Gly Ile Gly Leu Gly Val Ala Gln Gln Leu Thr Gly Ile                  20 25 30 aac tcc atc atg tac tac ggc cag gtt gtt ctc att gag gct ggt ttc 143 Asn Ser Ile Met Tyr Tyr Gly Gln Val Val Leu Ile Glu Ala Gly Phe              35 40 45 tcc gag aat gca gct ctg atc gcc aac gtg gcg cca gga gtg atc gca 191 Ser Glu Asn Ala Ala Leu Ile Ala Asn Val Ala Pro Gly Val Ile Ala          50 55 60 gtt gtc ggt gca ttc atc gca ctg tgg atg atg gat ggt atc aac cgc 239 Val Val Gly Ala Phe Ile Ala Leu Trp Met Met Asp Gly Ile Asn Arg      65 70 75 cgt acc acc ctc att acc ggt tat tct ctc acc acc att agc cac gta 287 Arg Thr Thr Leu Ile Thr Gly Tyr Ser Leu Thr Thr Ile Ser His Val  80 85 90 95 ttg atc ggt atc gca tcc gta gca ttc cca gtc ggc gat cct ctt cgc 335 Leu Ile Gly Ile Ala Ser Val Ala Phe Pro Val Gly Asp Pro Leu Arg                 100 105 110 ccc tac gtt atc ttg act ctg gtt gtg gtc ttc gtg gga tcc atg cag 383 Pro Tyr Val Ile Leu Thr Leu Val Val Val Phe Val Gly Ser Met Gln             115 120 125 acc ttc ctc aac gta gct acc tgg gtt atg ctc tct gag ctc ttc ccg 431 Thr Phe Leu Asn Val Ala Thr Trp Val Met Leu Ser Glu Leu Phe Pro         130 135 140 ctg gca atg cgc ggt ttc gca atc ggt atc tca gtg ttc ttc ctc tgg 479 Leu Ala Met Arg Gly Phe Ala Ile Gly Ile Ser Val Phe Phe Leu Trp     145 150 155 atc gca aac gcg ttc ctc gga ttg ttc ttc cca acc atc atg gaa gca 527 Ile Ala Asn Ala Phe Leu Gly Leu Phe Phe Pro Thr Ile Met Glu Ala 160 165 170 175 gta gga cta acc gga acc ttc ttc atg ttc gcc gga atc ggt gtg gtt 575 Val Gly Leu Thr Gly Thr Phe Phe Met Phe Ala Gly Ile Gly Val Val                 180 185 190 gcc ttg atc ttc atc tac acc cag gtt cct gaa act cgt gga cgt acc 623 Ala Leu Ile Phe Ile Tyr Thr Gln Val Pro Glu Thr Arg Gly Arg Thr             195 200 205 ttg gag gag att gat gag gat gtt act tcc ggt gtc att ttc aac aag 671 Leu Glu Glu Ile Asp Glu Asp Val Thr Ser Gly Val Ile Phe Asn Lys         210 215 220 gac atc cga aaa gga aag gtg cac taaaaaccca gacactgcat agataacacg 725 Asp Ile Arg Lys Gly Lys Val His     225 230 <210> 438 <211> 231 <212> PRT <213> Corynebacterium glutamicum <400> 438 Met Gly Leu Arg Glu Ile Leu Ser Ser Lys Trp Leu Val Arg Ile Leu   1 5 10 15 Leu Val Gly Ile Gly Leu Gly Val Ala Gln Gln Leu Thr Gly Ile Asn              20 25 30 Ser Ile Met Tyr Tyr Gly Gln Val Val Leu Ile Glu Ala Gly Phe Ser          35 40 45 Glu Asn Ala Ala Leu Ile Ala Asn Val Ala Pro Gly Val Ile Ala Val      50 55 60 Val Gly Ala Phe Ile Ala Leu Trp Met Met Asp Gly Ile Asn Arg Arg  65 70 75 80 Thr Thr Leu Ile Thr Gly Tyr Ser Leu Thr Thr Ile Ser His Val Leu                  85 90 95 Ile Gly Ile Ala Ser Val Ala Phe Pro Val Gly Asp Pro Leu Arg Pro             100 105 110 Tyr Val Ile Leu Thr Leu Val Val Val Phe Val Gly Ser Met Gln Thr         115 120 125 Phe Leu Asn Val Ala Thr Trp Val Met Leu Ser Glu Leu Phe Pro Leu     130 135 140 Ala Met Arg Gly Phe Ala Ile Gly Ile Ser Val Phe Phe Leu Trp Ile 145 150 155 160 Ala Asn Ala Phe Leu Gly Leu Phe Phe Pro Thr Ile Met Glu Ala Val                 165 170 175 Gly Leu Thr Gly Thr Phe Phe Met Phe Ala Gly Ile Gly Val Val Ala             180 185 190 Leu Ile Phe Ile Tyr Thr Gln Val Pro Glu Thr Arg Gly Arg Thr Leu         195 200 205 Glu Glu Ile Asp Glu Asp Val Thr Ser Gly Val Ile Phe Asn Lys Asp     210 215 220 Ile Arg Lys Gly Lys Val His 225 230 <210> 439 <211> 408 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (385) <223> FRXA02762 <400> 439 ttcccagtcg gcgatcctct tcgcccctac gttatcttga ctctggttgt ggtcttcgtg 60 ggatccatgc agaccttcct caacggtagc tacctgggtt atg ctc tct gag ctc 115                                             Met Leu Ser Glu Leu                                               1 5 ttc ccg ctg gca atg cgc ggt ttc gca atc ggt atc tca gtg ttc ttc 163 Phe Pro Leu Ala Met Arg Gly Phe Ala Ile Gly Ile Ser Val Phe Phe                  10 15 20 ctc tgg atc gca aac gcg ttc ctc gga ttg ttc ttc cca acc atc atg 211 Leu Trp Ile Ala Asn Ala Phe Leu Gly Leu Phe Phe Pro Thr Ile Met              25 30 35 gaa gca gta gga cta acc gga acc ttc ttc atg ttc gcc gga atc ggt 259 Glu Ala Val Gly Leu Thr Gly Thr Phe Phe Met Phe Ala Gly Ile Gly          40 45 50 gtg gtt gcc ttg atc ttc atc tac acc cag gtt cct gaa act cgt gga 307 Val Val Ala Leu Ile Phe Ile Tyr Thr Gln Val Pro Glu Thr Arg Gly      55 60 65 cgt acc ttg gag gag att gat gag gat gtt act tcc ggt gtc att ttc 355 Arg Thr Leu Glu Glu Ile Asp Glu Asp Val Thr Ser Gly Val Ile Phe  70 75 80 85 aac aag gac atc cga aaa gga aag gtg cac taaaaaccca gacactgcat 405 Asn Lys Asp Ile Arg Lys Gly Lys Val His                  90 95 aga 408 <210> 440 <211> 95 <212> PRT <213> Corynebacterium glutamicum <400> 440 Met Leu Ser Glu Leu Phe Pro Leu Ala Met Arg Gly Phe Ala Ile Gly   1 5 10 15 Ile Ser Val Phe Phe Leu Trp Ile Ala Asn Ala Phe Leu Gly Leu Phe              20 25 30 Phe Pro Thr Ile Met Glu Ala Val Gly Leu Thr Gly Thr Phe Phe Met          35 40 45 Phe Ala Gly Ile Gly Val Val Ala Leu Ile Phe Ile Tyr Thr Gln Val      50 55 60 Pro Glu Thr Arg Gly Arg Thr Leu Glu Glu Ile Asp Glu Asp Val Thr  65 70 75 80 Ser Gly Val Ile Phe Asn Lys Asp Ile Arg Lys Gly Lys Val His                  85 90 95 <210> 441 <211> 789 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (766) <223> RXN00092 <400> 441 cgaaaccaga aacacccagc ggctcctcgt cgaaaagcga atctttgaac tagaagccca 60 ggcacgttgg ctcgaccgaa ttgaagcatt ggagcagtaa atg aca aac acg cct 115                                             Met Thr Asn Thr Pro                                               1 5 ttc ccc ctt gaa ctt caa aac atc tcc tgc gcc ttc gga gaa ggc cca 163 Phe Pro Leu Glu Leu Gln Asn Ile Ser Cys Ala Phe Gly Glu Gly Pro                  10 15 20 cgc cac gtc tcc gcg ctc aac aac gtc tcg ctg gca gtc aat ccc ggc 211 Arg His Val Ser Ala Leu Asn Asn Val Ser Leu Ala Val Asn Pro Gly              25 30 35 gaa ctc gtt gcc atc atg ggc ccg tcc ggc tca gga aaa tcc acc ttg 259 Glu Leu Val Ala Ile Met Gly Pro Ser Gly Ser Gly Lys Ser Thr Leu          40 45 50 ctc aac gtc gcc ggc ctc ctg cag cgc gca acc tct ggc cat gtg ctt 307 Leu Asn Val Ala Gly Leu Leu Gln Arg Ala Thr Ser Gly His Val Leu      55 60 65 atc gac ggt gcc agc gcc tca gac ctc aac gcc aaa cgc gca gct gaa 355 Ile Asp Gly Ala Ser Ala Ser Asp Leu Asn Ala Lys Arg Ala Ala Glu  70 75 80 85 acc agg cgt cgc cac atc gga gtt att ttc caa aac tac aac ctg gtc 403 Thr Arg Arg Arg His Ile Gly Val Ile Phe Gln Asn Tyr Asn Leu Val                  90 95 100 ccc acc ctc acc gtc gga gaa aac gtc ggt ctg ccc cta gaa ctc gac 451 Pro Thr Leu Thr Val Gly Glu Asn Val Gly Leu Pro Leu Glu Leu Asp             105 110 115 ggc aaa acc gac cgc cag gca gta gca atc gca ctc gcg gaa gtc ggc 499 Gly Lys Thr Asp Arg Gln Ala Val Ala Ile Ala Leu Ala Glu Val Gly         120 125 130 ctc gaa ggc ttc gac gac cgc ttc ccc gaa gag atc tcc ggc ggc caa 547 Leu Glu Gly Phe Asp Asp Arg Phe Pro Glu Glu Ile Ser Gly Gly Gln     135 140 145 gcc cag cgc gtc gcc atc gcg aga gcc ctc atc ggc ccc cga aaa atc 595 Ala Gln Arg Val Ala Ile Ala Arg Ala Leu Ile Gly Pro Arg Lys Ile 150 155 160 165 ttg ctt gcc gac gaa ccc acc ggc gcc ctc gac acc tcc acc ggc gac 643 Leu Leu Ala Asp Glu Pro Thr Gly Ala Leu Asp Thr Ser Thr Gly Asp                 170 175 180 gca gtc ctc cgc gtc ctc cgc caa aga atc gat tcc ggt gcc gca ggc 691 Ala Val Leu Arg Val Leu Arg Gln Arg Ile Asp Ser Gly Ala Ala Gly             185 190 195 ctc ctt gtc acc cac gaa ccc cgc ttc gcc gcg tgg gca gac cga aca 739 Leu Leu Val Thr His Glu Pro Arg Phe Ala Ala Trp Ala Asp Arg Thr         200 205 210 atc atg ctt agg gat ggt gaa atc cag tgaccacact tctagcagca 786 Ile Met Leu Arg Asp Gly Glu Ile Gln     215 220 acc 789 <210> 442 <211> 222 <212> PRT <213> Corynebacterium glutamicum <400> 442 Met Thr Asn Thr Pro Phe Pro Leu Glu Leu Gln Asn Ile Ser Cys Ala   1 5 10 15 Phe Gly Glu Gly Pro Arg His Val Ser Ala Leu Asn Asn Val Ser Leu              20 25 30 Ala Val Asn Pro Gly Glu Leu Val Ala Ile Met Gly Pro Ser Gly Ser          35 40 45 Gly Lys Ser Thr Leu Leu Asn Val Ala Gly Leu Leu Gln Arg Ala Thr      50 55 60 Ser Gly His Val Leu Ile Asp Gly Ala Ser Ala Ser Asp Leu Asn Ala  65 70 75 80 Lys Arg Ala Ala Glu Thr Arg Arg Arg His Ile Gly Val Ile Phe Gln                  85 90 95 Asn Tyr Asn Leu Val Pro Thr Leu Thr Val Gly Glu Asn Val Gly Leu             100 105 110 Pro Leu Glu Leu Asp Gly Lys Thr Asp Arg Gln Ala Val Ala Ile Ala         115 120 125 Leu Ala Glu Val Gly Leu Glu Gly Phe Asp Asp Arg Phe Pro Glu Glu     130 135 140 Ile Ser Gly Gly Gln Ala Gln Arg Val Ala Ile Ala Arg Ala Leu Ile 145 150 155 160 Gly Pro Arg Lys Ile Leu Leu Ala Asp Glu Pro Thr Gly Ala Leu Asp                 165 170 175 Thr Ser Thr Gly Asp Ala Val Leu Arg Val Leu Arg Gln Arg Ile Asp             180 185 190 Ser Gly Ala Ala Gly Leu Leu Val Thr His Glu Pro Arg Phe Ala Ala         195 200 205 Trp Ala Asp Arg Thr Ile Met Leu Arg Asp Gly Glu Ile Gln     210 215 220 <210> 443 <211> 227 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (204) <223> FRXA00092 <400> 443 atc gcg aga gcc ctc atc ggc ccc cga aaa atc ttg ctt gcc gac gaa 48 Ile Ala Arg Ala Leu Ile Gly Pro Arg Lys Ile Leu Leu Ala Asp Glu   1 5 10 15 ccc acc ggc gcc ctc gac acc tcc acc ggc gac gca gtc ctc cgc gtc 96 Pro Thr Gly Ala Leu Asp Thr Ser Thr Gly Asp Ala Val Leu Arg Val              20 25 30 ctc cgc caa aga atc gat tcc ggt gcc gca ggc ctc ctt gtc acc cac 144 Leu Arg Gln Arg Ile Asp Ser Gly Ala Ala Gly Leu Leu Val Thr His          35 40 45 gaa ccc cgc ttc gcc gcg tgg gca gac cga aca atc atg ctt agg gat 192 Glu Pro Arg Phe Ala Ala Trp Ala Asp Arg Thr Ile Met Leu Arg Asp      50 55 60 ggt gaa atc cag tgaccacact tctagcagca acc 227 Gly Glu Ile Gln  65 <210> 444 <211> 68 <212> PRT <213> Corynebacterium glutamicum <400> 444 Ile Ala Arg Ala Leu Ile Gly Pro Arg Lys Ile Leu Leu Ala Asp Glu   1 5 10 15 Pro Thr Gly Ala Leu Asp Thr Ser Thr Gly Asp Ala Val Leu Arg Val              20 25 30 Leu Arg Gln Arg Ile Asp Ser Gly Ala Ala Gly Leu Leu Val Thr His          35 40 45 Glu Pro Arg Phe Ala Ala Trp Ala Asp Arg Thr Ile Met Leu Arg Asp      50 55 60 Gly Glu Ile Gln  65 <210> 445 <211> 975 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (952) <223> RXN03060 <400> 445 tatgtccttt ggctccggta ccctggcagg agtacctggg ctgtttttct aaaatggcct 60 gacgttttca agattgaatt taaggaaagc atcgtagttc atg agt aac cct gcc 115                                             Met ser asn pro ala                                               1 5 gcg agc aca cct gcc aac aat tcg gac gat gtt gcg aag gag aat tgg 163 Ala Ser Thr Pro Ala Asn Asn Ser Asp Asp Val Ala Lys Glu Asn Trp                  10 15 20 gac tct tct ttt acg ccg aag act gac att gac tct tcc cag cct gtc 211 Asp Ser Ser Phe Thr Pro Lys Thr Asp Ile Asp Ser Ser Gln Pro Val              25 30 35 aat aac tcg act ggt gaa gcc gct gcg cgc gca gtg aac ctg tac aag 259 Asn Asn Ser Thr Gly Glu Ala Ala Ala Arg Ala Val Asn Leu Tyr Lys          40 45 50 gcg tat ggc cag ggt gat acc act gtc acc gcg ttg gat cac gtc aac 307 Ala Tyr Gly Gln Gly Asp Thr Thr Val Thr Ala Leu Asp His Val Asn      55 60 65 gtg gag ttt gag aag aac aag ttc act gcc atc atg ggt cct tct ggc 355 Val Glu Phe Glu Lys Asn Lys Phe Thr Ala Ile Met Gly Pro Ser Gly  70 75 80 85 tcg ggt aag tcc acg ttg atg cac tgc atg gct ggt ctg gat gct gcg 403 Ser Gly Lys Ser Thr Leu Met His Cys Met Ala Gly Leu Asp Ala Ala                  90 95 100 act ggt ggt tcg gca ttc att ggt gat acg gat ctg tcg cgg ttg aag 451 Thr Gly Gly Ser Ala Phe Ile Gly Asp Thr Asp Leu Ser Arg Leu Lys             105 110 115 gac aaa gag atg acc tct ttg cgt cgt gat cgt ttg gga ttc att ttc 499 Asp Lys Glu Met Thr Ser Leu Arg Arg Asp Arg Leu Gly Phe Ile Phe         120 125 130 cag tcg ttc aac ttg gtt cct act ctg acg gcg tcg gag aac att acg 547 Gln Ser Phe Asn Leu Val Pro Thr Leu Thr Ala Ser Glu Asn Ile Thr     135 140 145 ctg cct acc gat atc gcg ggc cgc aag att gat cag tcg tgg ttc gat 595 Leu Pro Thr Asp Ile Ala Gly Arg Lys Ile Asp Gln Ser Trp Phe Asp 150 155 160 165 gag att acc tct cgt ctg ggt ctg act gag cgc ctt aag cac cgt cct 643 Glu Ile Thr Ser Arg Leu Gly Leu Thr Glu Arg Leu Lys His Arg Pro                 170 175 180 gca gag ctc tct ggt ggt cag cag cag cgt gtg gcg tgt gct cgt gcg 691 Ala Glu Leu Ser Gly Gly Gln Gln Gln Arg Val Ala Cys Ala Arg Ala             185 190 195 ttg gtg tct cgt ccg gag atc att ttc ggc gac gag cca acc ggt aac 739 Leu Val Ser Arg Pro Glu Ile Ile Phe Gly Asp Glu Pro Thr Gly Asn         200 205 210 ttg gat tcg aac tct tct agg gaa gtg ctg gat atc ctg cgc acc gca 787 Leu Asp Ser Asn Ser Ser Arg Glu Val Leu Asp Ile Leu Arg Thr Ala     215 220 225 gtt gat cag gat gat cag acc gtt gtg atc gtt acc cac gat gcc aag 835 Val Asp Gln Asp Asp Gln Thr Val Val Ile Val Thr His Asp Ala Lys 230 235 240 245 gcg gcg tcc tat gca gat cgt gtc att ttc ttg gcg gac ggt cgt atc 883 Ala Ala Ser Tyr Ala Asp Arg Val Ile Phe Leu Ala Asp Gly Arg Ile                 250 255 260 gtg aac cag ttg ttt gat ccc acc atc gag gaa atc ttg gcc acg atg 931 Val Asn Gln Leu Phe Asp Pro Thr Ile Glu Glu Ile Leu Ala Thr Met             265 270 275 aac gga att gag gat att gcc taatgaattc cggttccaca atg 975 Asn Gly Ile Glu Asp Ile Ala         280 <210> 446 <211> 284 <212> PRT <213> Corynebacterium glutamicum <400> 446 Met Ser Asn Pro Ala Ala Ser Thr Pro Ala Asn Asn Ser Asp Asp Val   1 5 10 15 Ala Lys Glu Asn Trp Asp Ser Ser Phe Thr Pro Lys Thr Asp Ile Asp              20 25 30 Ser Ser Gln Pro Val Asn Asn Ser Thr Gly Glu Ala Ala Ala Arg Ala          35 40 45 Val Asn Leu Tyr Lys Ala Tyr Gly Gln Gly Asp Thr Thr Val Thr Ala      50 55 60 Leu Asp His Val Asn Val Glu Phe Glu Lys Asn Lys Phe Thr Ala Ile  65 70 75 80 Met Gly Pro Ser Gly Ser Gly Lys Ser Thr Leu Met His Cys Met Ala                  85 90 95 Gly Leu Asp Ala Ala Thr Gly Gly Ser Ala Phe Ile Gly Asp Thr Asp             100 105 110 Leu Ser Arg Leu Lys Asp Lys Glu Met Thr Ser Leu Arg Arg Asp Arg         115 120 125 Leu Gly Phe Ile Phe Gln Ser Phe Asn Leu Val Pro Thr Leu Thr Ala     130 135 140 Ser Glu Asn Ile Thr Leu Pro Thr Asp Ile Ala Gly Arg Lys Ile Asp 145 150 155 160 Gln Ser Trp Phe Asp Glu Ile Thr Ser Arg Leu Gly Leu Thr Glu Arg                 165 170 175 Leu Lys His Arg Pro Ala Glu Leu Ser Gly Gly Gln Gln Gln Arg Val             180 185 190 Ala Cys Ala Arg Ala Leu Val Ser Arg Pro Glu Ile Ile Phe Gly Asp         195 200 205 Glu Pro Thr Gly Asn Leu Asp Ser Asn Ser Ser Arg Glu Val Leu Asp     210 215 220 Ile Leu Arg Thr Ala Val Asp Gln Asp Asp Gln Thr Val Val Ile Val 225 230 235 240 Thr His Asp Ala Lys Ala Ala Ser Tyr Ala Asp Arg Val Ile Phe Leu                 245 250 255 Ala Asp Gly Arg Ile Val Asn Gln Leu Phe Asp Pro Thr Ile Glu Glu             260 265 270 Ile Leu Ala Thr Met Asn Gly Ile Glu Asp Ile Ala         275 280 <210> 447 <211> 538 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (538) <223> FRXA02618 <400> 447 cgaaaccaga aacacccagc ggctcctcgt cgaaaagcga atctttgaac tagaagccca 60 ggcacgttgg ctcgaccgaa ttgaagcatt ggagcagtaa atg aca aac acg cct 115                                             Met Thr Asn Thr Pro                                               1 5 ttc ccc ctt gaa ctt caa aac atc tcc tgc gcc ttc gga gaa ggc cca 163 Phe Pro Leu Glu Leu Gln Asn Ile Ser Cys Ala Phe Gly Glu Gly Pro                  10 15 20 cgc cac gtc tcc gcg ctc aac aac gtc tcg ctg gca gtc aat ccc ggc 211 Arg His Val Ser Ala Leu Asn Asn Val Ser Leu Ala Val Asn Pro Gly              25 30 35 gaa ctc gtt gcc atc atg ggc ccg tcc ggc tca gga aaa tcc acc ttg 259 Glu Leu Val Ala Ile Met Gly Pro Ser Gly Ser Gly Lys Ser Thr Leu          40 45 50 ctc aac gtc gcc ggc ctc ctg cag cgc gca acc tct ggc cat gtg ctt 307 Leu Asn Val Ala Gly Leu Leu Gln Arg Ala Thr Ser Gly His Val Leu      55 60 65 atc gac ggt gcc agc gcc tca gac ctc aac gcc aaa cgc gca gct gaa 355 Ile Asp Gly Ala Ser Ala Ser Asp Leu Asn Ala Lys Arg Ala Ala Glu  70 75 80 85 acc agg cgt cgc cac atc gga gtt att ttc caa aac tac aac ctg gtc 403 Thr Arg Arg Arg His Ile Gly Val Ile Phe Gln Asn Tyr Asn Leu Val                  90 95 100 ccc acc ctc acc gtc gga gaa aac atc ggt ctg ccc cta gaa ctc gac 451 Pro Thr Leu Thr Val Gly Glu Asn Ile Gly Leu Pro Leu Glu Leu Asp             105 110 115 ggc aaa acc gac cgc cag gca gta gca atc gca ctc gcg gaa gtc ggc 499 Gly Lys Thr Asp Arg Gln Ala Val Ala Ile Ala Leu Ala Glu Val Gly         120 125 130 ctc aag ggc tct acg acc gct ttt ccc gag aga tct ctg 538 Leu Lys Gly Ser Thr Thr Ala Phe Pro Glu Arg Ser Leu     135 140 145 <210> 448 <211> 146 <212> PRT <213> Corynebacterium glutamicum <400> 448 Met Thr Asn Thr Pro Phe Pro Leu Glu Leu Gln Asn Ile Ser Cys Ala   1 5 10 15 Phe Gly Glu Gly Pro Arg His Val Ser Ala Leu Asn Asn Val Ser Leu              20 25 30 Ala Val Asn Pro Gly Glu Leu Val Ala Ile Met Gly Pro Ser Gly Ser          35 40 45 Gly Lys Ser Thr Leu Leu Asn Val Ala Gly Leu Leu Gln Arg Ala Thr      50 55 60 Ser Gly His Val Leu Ile Asp Gly Ala Ser Ala Ser Asp Leu Asn Ala  65 70 75 80 Lys Arg Ala Ala Glu Thr Arg Arg Arg His Ile Gly Val Ile Phe Gln                  85 90 95 Asn Tyr Asn Leu Val Pro Thr Leu Thr Val Gly Glu Asn Ile Gly Leu             100 105 110 Pro Leu Glu Leu Asp Gly Lys Thr Asp Arg Gln Ala Val Ala Ile Ala         115 120 125 Leu Ala Glu Val Gly Leu Lys Gly Ser Thr Thr Ala Phe Pro Glu Arg     130 135 140 Ser leu 145 <210> 449 <211> 975 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (952) <223> FRXA02900 <400> 449 tatgtccttt ggctccggta ccctggcagg agtacctggg ctgtttttct aaaatggcct 60 gacgttttca agattgaatt taaggaaagc atcgtagttc atg agt aac cct gcc 115                                             Met ser asn pro ala                                               1 5 gcg agc aca cct gcc aac aat tcg gac gat gtt gcg aag gag aat tgg 163 Ala Ser Thr Pro Ala Asn Asn Ser Asp Asp Val Ala Lys Glu Asn Trp                  10 15 20 gac tct tct ttt acg ccg aag act gac att gac tct tcc cag cct gtc 211 Asp Ser Ser Phe Thr Pro Lys Thr Asp Ile Asp Ser Ser Gln Pro Val              25 30 35 aat aac tcg act ggt gaa gcc gct gcg cgc gca gtg aac ctg tac aag 259 Asn Asn Ser Thr Gly Glu Ala Ala Ala Arg Ala Val Asn Leu Tyr Lys          40 45 50 gcg tat ggc cag ggt gat acc act gtc acc gcg ttg gat cac gtc aac 307 Ala Tyr Gly Gln Gly Asp Thr Thr Val Thr Ala Leu Asp His Val Asn      55 60 65 gtg gag ttt gag aag aac aag ttc act gcc atc atg ggt cct tct ggc 355 Val Glu Phe Glu Lys Asn Lys Phe Thr Ala Ile Met Gly Pro Ser Gly  70 75 80 85 tcg ggt aag tcc acg ttg atg cac tgc atg gct ggt ctg gat gct gcg 403 Ser Gly Lys Ser Thr Leu Met His Cys Met Ala Gly Leu Asp Ala Ala                  90 95 100 act ggt ggt tcg gca ttc att ggt gat acg gat ctg tcg cgg ttg aag 451 Thr Gly Gly Ser Ala Phe Ile Gly Asp Thr Asp Leu Ser Arg Leu Lys             105 110 115 gac aaa gag atg acc tct ttg cgt cgt gat cgt ttg gga ttc att ttc 499 Asp Lys Glu Met Thr Ser Leu Arg Arg Asp Arg Leu Gly Phe Ile Phe         120 125 130 cag tcg ttc aac ttg gtt cct act ctg acg gcg tcg gag aac att acg 547 Gln Ser Phe Asn Leu Val Pro Thr Leu Thr Ala Ser Glu Asn Ile Thr     135 140 145 ctg cct acc gat atc gcg ggc cgc aag att gat cag tcg tgg ttc gat 595 Leu Pro Thr Asp Ile Ala Gly Arg Lys Ile Asp Gln Ser Trp Phe Asp 150 155 160 165 gag att acc tct cgt ctg ggt ctg act gag cgc ctt aag cac cgt cct 643 Glu Ile Thr Ser Arg Leu Gly Leu Thr Glu Arg Leu Lys His Arg Pro                 170 175 180 gca gag ctc tct ggt ggt cag cag cag cgt gtg gcg tgt gct cgt gcg 691 Ala Glu Leu Ser Gly Gly Gln Gln Gln Arg Val Ala Cys Ala Arg Ala             185 190 195 ttg gtg tct cgt ccg gag atc att ttc ggc gac gag cca acc ggt aac 739 Leu Val Ser Arg Pro Glu Ile Ile Phe Gly Asp Glu Pro Thr Gly Asn         200 205 210 ttg gat tcg aac tct tct agg gaa gtg ctg gat atc ctg cgc acc gca 787 Leu Asp Ser Asn Ser Ser Arg Glu Val Leu Asp Ile Leu Arg Thr Ala     215 220 225 gtt gat cag gat gat cag acc gtt gtg atc gtt acc cac gat gcc aag 835 Val Asp Gln Asp Asp Gln Thr Val Val Ile Val Thr His Asp Ala Lys 230 235 240 245 gcg gcg tcc tat gca gat cgt gtc att ttc ttg gcg gac ggt cgt atc 883 Ala Ala Ser Tyr Ala Asp Arg Val Ile Phe Leu Ala Asp Gly Arg Ile                 250 255 260 gtg aac cag ttg ttt gat ccc acc atc gag gaa atc ttg gcc acg atg 931 Val Asn Gln Leu Phe Asp Pro Thr Ile Glu Glu Ile Leu Ala Thr Met             265 270 275 aac gga att gag gat att gcc taatgaattc cggttccaca atg 975 Asn Gly Ile Glu Asp Ile Ala         280 <210> 450 <211> 284 <212> PRT <213> Corynebacterium glutamicum <400> 450 Met Ser Asn Pro Ala Ala Ser Thr Pro Ala Asn Asn Ser Asp Asp Val   1 5 10 15 Ala Lys Glu Asn Trp Asp Ser Ser Phe Thr Pro Lys Thr Asp Ile Asp              20 25 30 Ser Ser Gln Pro Val Asn Asn Ser Thr Gly Glu Ala Ala Ala Arg Ala          35 40 45 Val Asn Leu Tyr Lys Ala Tyr Gly Gln Gly Asp Thr Thr Val Thr Ala      50 55 60 Leu Asp His Val Asn Val Glu Phe Glu Lys Asn Lys Phe Thr Ala Ile  65 70 75 80 Met Gly Pro Ser Gly Ser Gly Lys Ser Thr Leu Met His Cys Met Ala                  85 90 95 Gly Leu Asp Ala Ala Thr Gly Gly Ser Ala Phe Ile Gly Asp Thr Asp             100 105 110 Leu Ser Arg Leu Lys Asp Lys Glu Met Thr Ser Leu Arg Arg Asp Arg         115 120 125 Leu Gly Phe Ile Phe Gln Ser Phe Asn Leu Val Pro Thr Leu Thr Ala     130 135 140 Ser Glu Asn Ile Thr Leu Pro Thr Asp Ile Ala Gly Arg Lys Ile Asp 145 150 155 160 Gln Ser Trp Phe Asp Glu Ile Thr Ser Arg Leu Gly Leu Thr Glu Arg                 165 170 175 Leu Lys His Arg Pro Ala Glu Leu Ser Gly Gly Gln Gln Gln Arg Val             180 185 190 Ala Cys Ala Arg Ala Leu Val Ser Arg Pro Glu Ile Ile Phe Gly Asp         195 200 205 Glu Pro Thr Gly Asn Leu Asp Ser Asn Ser Ser Arg Glu Val Leu Asp     210 215 220 Ile Leu Arg Thr Ala Val Asp Gln Asp Asp Gln Thr Val Val Ile Val 225 230 235 240 Thr His Asp Ala Lys Ala Ala Ser Tyr Ala Asp Arg Val Ile Phe Leu                 245 250 255 Ala Asp Gly Arg Ile Val Asn Gln Leu Phe Asp Pro Thr Ile Glu Glu             260 265 270 Ile Leu Ala Thr Met Asn Gly Ile Glu Asp Ile Ala         275 280 <210> 451 <211> 1452 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (1452) <223> RXS03212 <400> 451 gcc tca ctt aac tgg tca gtc atc gtt cca gcc cta gtc att gtc cta 48 Ala Ser Leu Asn Trp Ser Val Ile Val Pro Ala Leu Val Ile Val Leu   1 5 10 15 gcg aca gtg gtg tgg ggt atc gga ttc aaa gat agc ttt acc aac ttt 96 Ala Thr Val Val Trp Gly Ile Gly Phe Lys Asp Ser Phe Thr Asn Phe              20 25 30 gct agt tct gcg ttg tca gca gta gtt gac aat ctc ggc tgg gcc ttc 144 Ala Ser Ser Ala Leu Ser Ala Val Val Asp Asn Leu Gly Trp Ala Phe          35 40 45 att ttg ttt ggc aca gtc ttt gta ttt ttt atc gtt gtt atc gcc gct 192 Ile Leu Phe Gly Thr Val Phe Val Phe Phe Ile Val Val Ile Ala Ala      50 55 60 agt aaa ttc ggc acg att cgc tta ggc cgc att gat gaa gca cca gag 240 Ser Lys Phe Gly Thr Ile Arg Leu Gly Arg Ile Asp Glu Ala Pro Glu  65 70 75 80 ttt cgc acg gtg tca tgg att tcc atg atg ttt gct gca ggt atg ggt 288 Phe Arg Thr Val Ser Trp Ile Ser Met Met Phe Ala Ala Gly Met Gly                  85 90 95 att ggt ttg atg ttc tac gga acc aca gaa cct tta acc ttc tac cgc 336 Ile Gly Leu Met Phe Tyr Gly Thr Thr Glu Pro Leu Thr Phe Tyr Arg             100 105 110 aat ggt gta cct gga cat gat gaa cac aat gtt ggc gtt gct atg tcc 384 Asn Gly Val Pro Gly His Asp Glu His Asn Val Gly Val Ala Met Ser         115 120 125 acg aca atg ttc cac tgg acc ttg cat cca tgg gct atc tac gca att 432 Thr Thr Met Phe His Trp Thr Leu His Pro Trp Ala Ile Tyr Ala Ile     130 135 140 gtg ggc cta gcc att gcc tat tcg acc ttc cga gtg ggc cgt aaa cag 480 Val Gly Leu Ala Ile Ala Tyr Ser Thr Phe Arg Val Gly Arg Lys Gln 145 150 155 160 ctt cta agc tct gca ttc gtg cca ctc att ggt gaa aaa ggt gca gaa 528 Leu Leu Ser Ser Ala Phe Val Pro Leu Ile Gly Glu Lys Gly Ala Glu                 165 170 175 gga tgg ttg ggc aag ctc atc gac atc ctg gcg att atc gcc acc gta 576 Gly Trp Leu Gly Lys Leu Ile Asp Ile Leu Ala Ile Ile Ala Thr Val             180 185 190 ttc ggc acg gca tgt tcc ctt ggc ctt ggt gcc ctg cag att ggt gca 624 Phe Gly Thr Ala Cys Ser Leu Gly Leu Gly Ala Leu Gln Ile Gly Ala         195 200 205 ggc ctg tcc gca gca aac atc att gaa gat cca agc gat tgg acc atc 672 Gly Leu Ser Ala Ala Asn Ile Ilu Glu Asp Pro Ser Asp Trp Thr Ile     210 215 220 gtt ggc att gtt tct gtt ttg acc ctg gca ttt atc ttc tcc gct att 720 Val Gly Ile Val Ser Val Leu Thr Leu Ala Phe Ile Phe Ser Ala Ile 225 230 235 240 tct ggt gtg ggc aag gga atc cag tac ctc tcc aac gcc aac atg gtt 768 Ser Gly Val Gly Lys Gly Ile Gln Tyr Leu Ser Asn Ala Asn Met Val                 245 250 255 ctg gca gct ctg ctc gcg att ttc gtg ttc gtt gtc gga cca acc gtg 816 Leu Ala Ala Leu Leu Ala Ile Phe Val Phe Val Val Gly Pro Thr Val             260 265 270 tcg att ttg aac ctg ctg cca ggt tct att ggc aac tac ctg tcc aac 864 Ser Ile Leu Asn Leu Leu Pro Gly Ser Ile Gly Asn Tyr Leu Ser Asn         275 280 285 ttc ttt caa atg gca ggc cgc act gcc atg agt gcc gac ggc aca gca 912 Phe Phe Gln Met Ala Gly Arg Thr Ala Met Ser Ala Asp Gly Thr Ala     290 295 300 ggt gag tgg cta ggt agc tgg acc atc ttc tac tgg gca tgg tgg atc 960 Gly Glu Trp Leu Gly Ser Trp Thr Ile Phe Tyr Trp Ala Trp Trp Ile 305 310 315 320 tct tgg tca cca ttc gta gga atg ttc ttg gca cgt att tcc cgt ggc 1008 Ser Trp Ser Pro Phe Val Gly Met Phe Leu Ala Arg Ile Ser Arg Gly                 325 330 335 cgc tcc atc cgt gag ttc atc ctg ggc gtg ttg ctc gtc cca gca ggt 1056 Arg Ser Ile Arg Glu Phe Ile Leu Gly Val Leu Leu Val Pro Ala Gly             340 345 350 gtg tcc acc gta tgg ttc tcc att ttt ggt ggc act gcg att gtc ttc 1104 Val Ser Thr Val Trp Phe Ser Ile Phe Gly Gly Thr Ala Ile Val Phe         355 360 365 gaa caa aat ggg gaa tcc att tgg ggt gat ggt gca gca gaa gag cag 1152 Glu Gln Asn Gly Glu Ser Ile Trp Gly Asp Gly Ala Ala Glu Glu Gln     370 375 380 ctt ttt gga ttg ctt cat gca ctt cca ggt ggg caa atc atg ggc atc 1200 Leu Phe Gly Leu Leu His Ala Leu Pro Gly Gly Gln Ile Met Gly Ile 385 390 395 400 atc gcc atg att ttg ctg ggt act ttc ttc att acc tct gct gac tct 1248 Ile Ala Met Ile Leu Leu Gly Thr Phe Phe Ile Thr Ser Ala Asp Ser                 405 410 415 gct tcc acc gtc atg ggc acc atg agt cag cac ggc cag ctg gaa gcc 1296 Ala Ser Thr Val Met Gly Thr Met Ser Gln His Gly Gln Leu Glu Ala             420 425 430 aac aag tgg gtg aca gct gcc tgg ggt gtt gct acc gca gct att gga 1344 Asn Lys Trp Val Thr Ala Ala Trp Gly Val Ala Thr Ala Ala Ile Gly         435 440 445 cta acg cta ttg ctt tct ggt ggt gac aat gcc ttg agc aac ttg caa 1392 Leu Thr Leu Leu Leu Ser Gly Gly Asp Asn Ala Leu Ser Asn Leu Gln     450 455 460 aac gtc acc atc gtg gct gca aca cca ttc ttg ttt gtg gtt att gga 1440 Asn Val Thr Ile Val Ala Ala Thr Pro Phe Leu Phe Val Val Ile Gly 465 470 475 480 ttg atg ttt gcg 1452 Leu Met Phe Ala <210> 452 <211> 484 <212> PRT <213> Corynebacterium glutamicum <400> 452 Ala Ser Leu Asn Trp Ser Val Ile Val Pro Ala Leu Val Ile Val Leu   1 5 10 15 Ala Thr Val Val Trp Gly Ile Gly Phe Lys Asp Ser Phe Thr Asn Phe              20 25 30 Ala Ser Ser Ala Leu Ser Ala Val Val Asp Asn Leu Gly Trp Ala Phe          35 40 45 Ile Leu Phe Gly Thr Val Phe Val Phe Phe Ile Val Val Ile Ala Ala      50 55 60 Ser Lys Phe Gly Thr Ile Arg Leu Gly Arg Ile Asp Glu Ala Pro Glu  65 70 75 80 Phe Arg Thr Val Ser Trp Ile Ser Met Met Phe Ala Ala Gly Met Gly                  85 90 95 Ile Gly Leu Met Phe Tyr Gly Thr Thr Glu Pro Leu Thr Phe Tyr Arg             100 105 110 Asn Gly Val Pro Gly His Asp Glu His Asn Val Gly Val Ala Met Ser         115 120 125 Thr Thr Met Phe His Trp Thr Leu His Pro Trp Ala Ile Tyr Ala Ile     130 135 140 Val Gly Leu Ala Ile Ala Tyr Ser Thr Phe Arg Val Gly Arg Lys Gln 145 150 155 160 Leu Leu Ser Ser Ala Phe Val Pro Leu Ile Gly Glu Lys Gly Ala Glu                 165 170 175 Gly Trp Leu Gly Lys Leu Ile Asp Ile Leu Ala Ile Ile Ala Thr Val             180 185 190 Phe Gly Thr Ala Cys Ser Leu Gly Leu Gly Ala Leu Gln Ile Gly Ala         195 200 205 Gly Leu Ser Ala Ala Asn Ile Ilu Glu Asp Pro Ser Asp Trp Thr Ile     210 215 220 Val Gly Ile Val Ser Val Leu Thr Leu Ala Phe Ile Phe Ser Ala Ile 225 230 235 240 Ser Gly Val Gly Lys Gly Ile Gln Tyr Leu Ser Asn Ala Asn Met Val                 245 250 255 Leu Ala Ala Leu Leu Ala Ile Phe Val Phe Val Val Gly Pro Thr Val             260 265 270 Ser Ile Leu Asn Leu Leu Pro Gly Ser Ile Gly Asn Tyr Leu Ser Asn         275 280 285 Phe Phe Gln Met Ala Gly Arg Thr Ala Met Ser Ala Asp Gly Thr Ala     290 295 300 Gly Glu Trp Leu Gly Ser Trp Thr Ile Phe Tyr Trp Ala Trp Trp Ile 305 310 315 320 Ser Trp Ser Pro Phe Val Gly Met Phe Leu Ala Arg Ile Ser Arg Gly                 325 330 335 Arg Ser Ile Arg Glu Phe Ile Leu Gly Val Leu Leu Val Pro Ala Gly             340 345 350 Val Ser Thr Val Trp Phe Ser Ile Phe Gly Gly Thr Ala Ile Val Phe         355 360 365 Glu Gln Asn Gly Glu Ser Ile Trp Gly Asp Gly Ala Ala Glu Glu Gln     370 375 380 Leu Phe Gly Leu Leu His Ala Leu Pro Gly Gly Gln Ile Met Gly Ile 385 390 395 400 Ile Ala Met Ile Leu Leu Gly Thr Phe Phe Ile Thr Ser Ala Asp Ser                 405 410 415 Ala Ser Thr Val Met Gly Thr Met Ser Gln His Gly Gln Leu Glu Ala             420 425 430 Asn Lys Trp Val Thr Ala Ala Trp Gly Val Ala Thr Ala Ala Ile Gly         435 440 445 Leu Thr Leu Leu Leu Ser Gly Gly Asp Asn Ala Leu Ser Asn Leu Gln     450 455 460 Asn Val Thr Ile Val Ala Ala Thr Pro Phe Leu Phe Val Val Ile Gly 465 470 475 480 Leu Met Phe Ala <210> 453 <211> 945 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (945) <223> FRXA01591 <400> 453 gcc tca ctt aac tgg tca gtc atc gtt cca gcc cta gtc att gtc cta 48 Ala Ser Leu Asn Trp Ser Val Ile Val Pro Ala Leu Val Ile Val Leu   1 5 10 15 gcg aca gtg gtg tgg ggt atc gga ttc aaa gat agc ttt acc acc ttt 96 Ala Thr Val Val Trp Gly Ile Gly Phe Lys Asp Ser Phe Thr Thr Phe              20 25 30 gct agt tct gcg ttg tca gca gta gtt gac aat ctc ggc tgg gcc ttc 144 Ala Ser Ser Ala Leu Ser Ala Val Val Asp Asn Leu Gly Trp Ala Phe          35 40 45 att ttg ttt ggc aca gtc ttt gta ttt ttt atc gtt gtt atc gcc gct 192 Ile Leu Phe Gly Thr Val Phe Val Phe Phe Ile Val Val Ile Ala Ala      50 55 60 agt aaa ttc ggc acg att cgc tta ggc cgc att gat gaa gca cca gag 240 Ser Lys Phe Gly Thr Ile Arg Leu Gly Arg Ile Asp Glu Ala Pro Glu  65 70 75 80 ttt cgc acg gtg tca tgg att tcc atg atg ttt gct gca ggt atg ggt 288 Phe Arg Thr Val Ser Trp Ile Ser Met Met Phe Ala Ala Gly Met Gly                  85 90 95 att ggt ttg atg ttc tac gga acc aca gaa cct tta acc ttc tac cgc 336 Ile Gly Leu Met Phe Tyr Gly Thr Thr Glu Pro Leu Thr Phe Tyr Arg             100 105 110 aat ggt gta cct gga cat gat gaa cac aat gtt ggc gtt gct atg tcc 384 Asn Gly Val Pro Gly His Asp Glu His Asn Val Gly Val Ala Met Ser         115 120 125 acg aca atg ttc cac tgg acc ttg cat cca tgg gct atc tac gca att 432 Thr Thr Met Phe His Trp Thr Leu His Pro Trp Ala Ile Tyr Ala Ile     130 135 140 gtg ggc cta gcc att gcc tat tcg acc ttc cga gtg ggc cgt aaa cag 480 Val Gly Leu Ala Ile Ala Tyr Ser Thr Phe Arg Val Gly Arg Lys Gln 145 150 155 160 ctt cta agc tct gca ttc gtg cca ctc att ggt gaa aaa ggt gca gaa 528 Leu Leu Ser Ser Ala Phe Val Pro Leu Ile Gly Glu Lys Gly Ala Glu                 165 170 175 gga tgg ttg ggc aag ctc atc gac atc ctg gcg att atc gcc acc gta 576 Gly Trp Leu Gly Lys Leu Ile Asp Ile Leu Ala Ile Ile Ala Thr Val             180 185 190 ttc ggc acg gca tgt tcc ctt ggc ctt ggt gcc ctg cag att ggt gca 624 Phe Gly Thr Ala Cys Ser Leu Gly Leu Gly Ala Leu Gln Ile Gly Ala         195 200 205 ggc ctg tcc gca gca aac atc att gaa gat cca agc gat tgg acc atc 672 Gly Leu Ser Ala Ala Asn Ile Ilu Glu Asp Pro Ser Asp Trp Thr Ile     210 215 220 gtt ggc att gtt tct gtt ttg acc ctg gca ttt atc ttc tcc gct att 720 Val Gly Ile Val Ser Val Leu Thr Leu Ala Phe Ile Phe Ser Ala Ile 225 230 235 240 tct ggt gtg ggc aag gga atc cag tac ctc tcc aac gcc aac atg gtt 768 Ser Gly Val Gly Lys Gly Ile Gln Tyr Leu Ser Asn Ala Asn Met Val                 245 250 255 ctg gca gct ctg ctc gcg att ttc gtg ttc gtt gtc gga cca acc gtg 816 Leu Ala Ala Leu Leu Ala Ile Phe Val Phe Val Val Gly Pro Thr Val             260 265 270 tcg att ttg aac ctg ctg cca ggt tct att gtg aac tac ctg tcc aac 864 Ser Ile Leu Asn Leu Leu Pro Gly Ser Ile Val Asn Tyr Leu Ser Asn         275 280 285 ttc ttt caa atg gta ggc cgc act gcc atg agt gcc gac ggc aca cca 912 Phe Phe Gln Met Val Gly Arg Thr Ala Met Ser Ala Asp Gly Thr Pro     290 295 300 ggt gag tgg ctt ggt ggc tgc acc atc ttc tac 945 Gly Glu Trp Leu Gly Gly Cys Thr Ile Phe Tyr 305 310 315 <210> 454 <211> 315 <212> PRT <213> Corynebacterium glutamicum <400> 454 Ala Ser Leu Asn Trp Ser Val Ile Val Pro Ala Leu Val Ile Val Leu   1 5 10 15 Ala Thr Val Val Trp Gly Ile Gly Phe Lys Asp Ser Phe Thr Thr Phe              20 25 30 Ala Ser Ser Ala Leu Ser Ala Val Val Asp Asn Leu Gly Trp Ala Phe          35 40 45 Ile Leu Phe Gly Thr Val Phe Val Phe Phe Ile Val Val Ile Ala Ala      50 55 60 Ser Lys Phe Gly Thr Ile Arg Leu Gly Arg Ile Asp Glu Ala Pro Glu  65 70 75 80 Phe Arg Thr Val Ser Trp Ile Ser Met Met Phe Ala Ala Gly Met Gly                  85 90 95 Ile Gly Leu Met Phe Tyr Gly Thr Thr Glu Pro Leu Thr Phe Tyr Arg             100 105 110 Asn Gly Val Pro Gly His Asp Glu His Asn Val Gly Val Ala Met Ser         115 120 125 Thr Thr Met Phe His Trp Thr Leu His Pro Trp Ala Ile Tyr Ala Ile     130 135 140 Val Gly Leu Ala Ile Ala Tyr Ser Thr Phe Arg Val Gly Arg Lys Gln 145 150 155 160 Leu Leu Ser Ser Ala Phe Val Pro Leu Ile Gly Glu Lys Gly Ala Glu                 165 170 175 Gly Trp Leu Gly Lys Leu Ile Asp Ile Leu Ala Ile Ile Ala Thr Val             180 185 190 Phe Gly Thr Ala Cys Ser Leu Gly Leu Gly Ala Leu Gln Ile Gly Ala         195 200 205 Gly Leu Ser Ala Ala Asn Ile Ilu Glu Asp Pro Ser Asp Trp Thr Ile     210 215 220 Val Gly Ile Val Ser Val Leu Thr Leu Ala Phe Ile Phe Ser Ala Ile 225 230 235 240 Ser Gly Val Gly Lys Gly Ile Gln Tyr Leu Ser Asn Ala Asn Met Val                 245 250 255 Leu Ala Ala Leu Leu Ala Ile Phe Val Phe Val Val Gly Pro Thr Val             260 265 270 Ser Ile Leu Asn Leu Leu Pro Gly Ser Ile Val Asn Tyr Leu Ser Asn         275 280 285 Phe Phe Gln Met Val Gly Arg Thr Ala Met Ser Ala Asp Gly Thr Pro     290 295 300 Gly Glu Trp Leu Gly Gly Cys Thr Ile Phe Tyr 305 310 315 <210> 455 <211> 292 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (101) .. (292) <223> RXN00201 <400> 455 acgtcgcgga cttcaagtag tcggcgatga aaaagtccgt ttactaaacc ccgatctgtg 60 ttacgccatc gcgcggctcg ggcacaccga tacctgggca gtg gca gat tgc gga 115                                             Val Ala Asp Cys Gly                                               1 5 tta ccc atc cca gaa cac gta gag atc atc gat ttg gca ctc gtg ttt 163 Leu Pro Ile Pro Glu His Val Glu Ile Asp Leu Ala Leu Val Phe                  10 15 20 ggg atc ccc acc ttt gaa caa gta ctg aat gct ctc aag ccg gaa gta 211 Gly Ile Pro Thr Phe Glu Gln Val Leu Asn Ala Leu Lys Pro Glu Val              25 30 35 gtt gtg gaa ggc gcg gtg att gcc gaa ggg gca ccc caa cgt atc cgc 259 Val Val Glu Gly Ala Val Ile Ala Glu Gly Ala Pro Gln Arg Ile Arg          40 45 50 gaa atg gtg gat acg gat gtg gaa gta tgt gcg 292 Glu Met Val Asp Thr Asp Val Glu Val Cys Ala      55 60 <210> 456 <211> 64 <212> PRT <213> Corynebacterium glutamicum <400> 456 Val Ala Asp Cys Gly Leu Pro Ile Pro Glu His Val Glu Ile Ile Asp   1 5 10 15 Leu Ala Leu Val Phe Gly Ile Pro Thr Phe Glu Gln Val Leu Asn Ala              20 25 30 Leu Lys Pro Glu Val Val Val Glu Gly Ala Val Ile Ala Glu Gly Ala          35 40 45 Pro Gln Arg Ile Arg Glu Met Val Asp Thr Asp Val Glu Val Cys Ala      50 55 60 <210> 457 <211> 286 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (286) <223> FRXA00201 <400> 457 acgtcgcgga cttcaagtag tcggcgatga aaaagtccgt ttactaaacc ccgatctgtg 60 ttacgccatc gcgcggctcg ggcacaccga tacctgggca gtg gca gat tgc gga 115                                             Val Ala Asp Cys Gly                                               1 5 tta ccc atc cca gaa cac gta gag atc atc gat ttg gca ctc gtg ttt 163 Leu Pro Ile Pro Glu His Val Glu Ile Asp Leu Ala Leu Val Phe                  10 15 20 ggg atc ccc acc ttt gaa caa gta ctg aat gct ctc aag ccg gaa gta 211 Gly Ile Pro Thr Phe Glu Gln Val Leu Asn Ala Leu Lys Pro Glu Val              25 30 35 gtt gtg gaa ggc gcg gtg att gcc gaa ggg gca ccc caa cgt atc cgc 259 Val Val Glu Gly Ala Val Ile Ala Glu Gly Ala Pro Gln Arg Ile Arg          40 45 50 gaa atg gtg gat acg gat gtg gaa gtt 286 Glu Met Val Asp Thr Asp Val Glu Val      55 60 <210> 458 <211> 62 <212> PRT <213> Corynebacterium glutamicum <400> 458 Val Ala Asp Cys Gly Leu Pro Ile Pro Glu His Val Glu Ile Ile Asp   1 5 10 15 Leu Ala Leu Val Phe Gly Ile Pro Thr Phe Glu Gln Val Leu Asn Ala              20 25 30 Leu Lys Pro Glu Val Val Val Glu Gly Ala Val Ile Ala Glu Gly Ala          35 40 45 Pro Gln Arg Ile Arg Glu Met Val Asp Thr Asp Val Glu Val      50 55 60 <210> 459 <211> 849 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (826) <223> RXA01221 <400> 459 tccagggtgc gatcctggtt ctcgtgatcg tgttgctgcc gggcggaatt gcttcaatta 60 aactttccgc gctcaaaaat aaggccagga aggccacctc atg agc ctt aaa atc 115                                             Met Ser Leu Lys Ile                                               1 5 acc aac ctc aaa gtc gct ttc ggg tcg ttc atc gcc gtg aat gag att 163 Thr Asn Leu Lys Val Ala Phe Gly Ser Phe Ile Ala Val Asn Glu Ile                  10 15 20 agt ttt cag gtg ctg ccc ggt cac gtc cac ttc ctc atc ggt gcc aac 211 Ser Phe Gln Val Leu Pro Gly His Val His Phe Leu Ile Gly Ala Asn              25 30 35 ggt gca ggt aaa acc acc tgc att gac gcg atc agc gga ttg gcg ccg 259 Gly Ala Gly Lys Thr Thr Cys Ile Asp Ala Ile Ser Gly Leu Ala Pro          40 45 50 ggg cag gga tca gtg cag ttg gat ggc act gag att ctg gga acc cct 307 Gly Gln Gly Ser Val Gln Leu Asp Gly Thr Glu Ile Leu Gly Thr Pro      55 60 65 gtg cac cgc att gct cgg atg ggt gtg ggg cga acg ttt cag acc gcc 355 Val His Arg Ile Ala Arg Met Gly Val Gly Arg Thr Phe Gln Thr Ala  70 75 80 85 agc gtg ttt gaa gaa ttg tct gtg ttg cag aat ctg gat att gcg tgc 403 Ser Val Phe Glu Glu Leu Ser Val Leu Gln Asn Leu Asp Ile Ala Cys                  90 95 100 ggg att cat cgt ccg ttg cgg gcg ctt ctc ggg gtg cgt cat cgg att 451 Gly Ile His Arg Pro Leu Arg Ala Leu Leu Gly Val Arg His Arg Ile             105 110 115 gat ccc cga att gaa cac gcc ctg gag gtc acg ggt ctt gct gat ctg 499 Asp Pro Arg Ile Glu His Ala Leu Glu Val Thr Gly Leu Ala Asp Leu         120 125 130 gtg aat gct cag gcg gga acc ttg tcg cat ggg cag aaa cag tgg ctg 547 Val Asn Ala Gln Ala Gly Thr Leu Ser His Gly Gln Lys Gln Trp Leu     135 140 145 gaa att gca atg ttg ctg gtg cag gat gcg cag gtg ctc atg ctg gat 595 Glu Ile Ala Met Leu Leu Val Gln Asp Ala Gln Val Leu Met Leu Asp 150 155 160 165 gag ccg gtg gcg ggc atg agt gag gag gag cgt gtc gca acg ggt gag 643 Glu Pro Val Ala Gly Met Ser Glu Glu Glu Arg Val Ala Thr Gly Glu                 170 175 180 ctt ttg cag agg gtt gcg cgg gga cgg gtg gtg ttg gtg gtg gag cac 691 Leu Leu Gln Arg Val Ala Arg Gly Arg Val Val Leu Val Val Glu His             185 190 195 gat atg gag ttc atg cgt cgt ttt gcc act cgc gtc act gtg atg aat 739 Asp Met Glu Phe Met Arg Arg Phe Ala Thr Arg Val Thr Val Met Asn         200 205 210 cgc ggc acg atc ttg tgt gag ggg tcg gtc gat gag att cag gcg aat 787 Arg Gly Thr Ile Leu Cys Glu Gly Ser Val Asp Glu Ile Gln Ala Asn     215 220 225 ccg gat gtg cag tcc att tat tta ggt acg gca ggg aag tgagttagtc 836 Pro Asp Val Gln Ser Ile Tyr Leu Gly Thr Ala Gly Lys 230 235 240 atgttggaaa tca 849 <210> 460 <211> 242 <212> PRT <213> Corynebacterium glutamicum <400> 460 Met Ser Leu Lys Ile Thr Asn Leu Lys Val Ala Phe Gly Ser Phe Ile   1 5 10 15 Ala Val Asn Glu Ile Ser Phe Gln Val Leu Pro Gly His Val His Phe              20 25 30 Leu Ile Gly Ala Asn Gly Ala Gly Lys Thr Thr Cys Ile Asp Ala Ile          35 40 45 Ser Gly Leu Ala Pro Gly Gln Gly Ser Val Gln Leu Asp Gly Thr Glu      50 55 60 Ile Leu Gly Thr Pro Val His Arg Ile Ala Arg Met Gly Val Gly Arg  65 70 75 80 Thr Phe Gln Thr Ala Ser Val Phe Glu Glu Leu Ser Val Leu Gln Asn                  85 90 95 Leu Asp Ile Ala Cys Gly Ile His Arg Pro Leu Arg Ala Leu Leu Gly             100 105 110 Val Arg His Arg Ile Asp Pro Arg Ile Glu His Ala Leu Glu Val Thr         115 120 125 Gly Leu Ala Asp Leu Val Asn Ala Gln Ala Gly Thr Leu Ser His Gly     130 135 140 Gln Lys Gln Trp Leu Glu Ile Ala Met Leu Leu Val Gln Asp Ala Gln 145 150 155 160 Val Leu Met Leu Asp Glu Pro Val Ala Gly Met Ser Glu Glu Glu Arg                 165 170 175 Val Ala Thr Gly Glu Leu Leu Gln Arg Val Ala Arg Gly Arg Val Val             180 185 190 Leu Val Val Glu His Asp Met Glu Phe Met Arg Arg Phe Ala Thr Arg         195 200 205 Val Thr Val Met Asn Arg Gly Thr Ile Leu Cys Glu Gly Ser Val Asp     210 215 220 Glu Ile Gln Ala Asn Pro Asp Val Gln Ser Ile Tyr Leu Gly Thr Ala 225 230 235 240 Gly lys <210> 461 <211> 822 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (799) <223> RXA01222 <400> 461 aatcgcggca cgatcttgtg tgaggggtcg gtcgatgaga ttcaggcgaa tccggatgtg 60 cagtccattt atttaggtac ggcagggaag tgagttagtc atg ttg gaa atc act 115                                             Met Leu Glu Ile Thr                                               1 5 aat ttg tgt gca ggt tat ggc cgc acg cag gta ctt cat tct ctt tca 163 Asn Leu Cys Ala Gly Tyr Gly Arg Thr Gln Val Leu His Ser Leu Ser                  10 15 20 atc tcc acg agc agc aac ggc atc ctg tcg atc ctc ggc cac aat ggc 211 Ile Ser Thr Ser Ser Asn Gly Ile Leu Ser Ile Leu Gly His Asn Gly              25 30 35 gct ggt aaa tcc acc ttg ctg cga acc gcg gtg ggg ttg att aag ccg 259 Ala Gly Lys Ser Thr Leu Leu Arg Thr Ala Val Gly Leu Ile Lys Pro          40 45 50 act tcc gga gag gtc aaa ctt ttc ggc cag gat gtc acc tcg ttg tcc 307 Thr Ser Gly Glu Val Lys Leu Phe Gly Gln Asp Val Thr Ser Leu Ser      55 60 65 acg cat gag cga gta aag cgc gga atg gct tat gtg ccg cag ggc cag 355 Thr His Glu Arg Val Lys Arg Gly Met Ala Tyr Val Pro Gln Gly Gln  70 75 80 85 cag tct ttt acg cag ctt agt tgc atg gaa aat ttg cag gtg gta gcg 403 Gln Ser Phe Thr Gln Leu Ser Cys Met Glu Asn Leu Gln Val Val Ala                  90 95 100 gat ctg cag gga cgt gtg ggc aag gca cgc atc gcg gag gcg ctt gat 451 Asp Leu Gln Gly Arg Val Gly Lys Ala Arg Ile Ala Glu Ala Leu Asp             105 110 115 cgc ttt ccg gcg ctg acc cag gtg ctg gac cgc caa gcc ggc ctg ttg 499 Arg Phe Pro Ala Leu Thr Gln Val Leu Asp Arg Gln Ala Gly Leu Leu         120 125 130 tcg ggt ggt cag cgt cag cag ctt gcc atc gcc cgc gcg ctg atc acg 547 Ser Gly Gly Gln Arg Gln Gln Leu Ala Ile Ala Arg Ala Leu Ile Thr     135 140 145 gcg cca aag ctt ttg ctt ctc gac gaa ccc acc gag ggt att cag cct 595 Ala Pro Lys Leu Leu Leu Leu Asp Glu Pro Thr Glu Gly Ile Gln Pro 150 155 160 165 tcg gtg gtt gct gaa att cag cag acc atc atc gat ttg gct aag gac 643 Ser Val Val Ala Glu Ile Gln Gln Thr Ile Ile Asp Leu Ala Lys Asp                 170 175 180 ggc atg agc att gtc ctg gtg gag caa aac att ggt ttt gca ttg gat 691 Gly Met Ser Ile Val Leu Val Glu Gln Asn Ile Gly Phe Ala Leu Asp             185 190 195 gct gca aca agc tac gcc att gtg gcg cgt ggt cag gtc gtg gaa tcg 739 Ala Ala Thr Ser Tyr Ala Ile Val Ala Arg Gly Gln Val Val Glu Ser         200 205 210 gga caa ggc gct gaa acc acc gca gag aag cag act aaa gtg cgg gaa 787 Gly Gln Gly Ala Glu Thr Thr Ala Glu Lys Gln Thr Lys Val Arg Glu     215 220 225 tct cta gca atc tagcggctgt ggatagcgtt ttg 822 Ser leu ala ile 230 <210> 462 <211> 233 <212> PRT <213> Corynebacterium glutamicum <400> 462 Met Leu Glu Ile Thr Asn Leu Cys Ala Gly Tyr Gly Arg Thr Gln Val   1 5 10 15 Leu His Ser Leu Ser Ile Ser Thr Ser Ser Asn Gly Ile Leu Ser Ile              20 25 30 Leu Gly His Asn Gly Ala Gly Lys Ser Thr Leu Leu Arg Thr Ala Val          35 40 45 Gly Leu Ile Lys Pro Thr Ser Gly Glu Val Lys Leu Phe Gly Gln Asp      50 55 60 Val Thr Ser Leu Ser Thr His Glu Arg Val Lys Arg Gly Met Ala Tyr  65 70 75 80 Val Pro Gln Gly Gln Gln Ser Phe Thr Gln Leu Ser Cys Met Glu Asn                  85 90 95 Leu Gln Val Val Ala Asp Leu Gln Gly Arg Val Gly Lys Ala Arg Ile             100 105 110 Ala Glu Ala Leu Asp Arg Phe Pro Ala Leu Thr Gln Val Leu Asp Arg         115 120 125 Gln Ala Gly Leu Leu Ser Gly Gly Gln Arg Gln Gln Leu Ala Ile Ala     130 135 140 Arg Ala Leu Ile Thr Ala Pro Lys Leu Leu Leu Leu Asp Glu Pro Thr 145 150 155 160 Glu Gly Ile Gln Pro Ser Val Val Ala Glu Ile Gln Gln Thr Ile Ile                 165 170 175 Asp Leu Ala Lys Asp Gly Met Ser Ile Val Leu Val Glu Gln Asn Ile             180 185 190 Gly Phe Ala Leu Asp Ala Ala Thr Ser Tyr Ala Ile Val Ala Arg Gly         195 200 205 Gln Val Val Glu Ser Gly Gln Gly Ala Glu Thr Thr Ala Glu Lys Gln     210 215 220 Thr Lys Val Arg Glu Ser Leu Ala Ile 225 230 <210> 463 <211> 1005 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (982) <223> RXA01219 <400> 463 caccatttgg gaaaccgatt ccccagttga tccggaccca tacttgtctt cctatgactg 60 ggccaagacc accgctgcga cttcctaaga gataaaaatc atg gac att tta ctc 115                                             Met Asp Ile Leu Leu                                               1 5 aat cag ctc gta gcc ggg ctt tca gtt gga tcg gtc ctt cta ttg gtc 163 Asn Gln Leu Val Ala Gly Leu Ser Val Gly Ser Val Leu Leu Leu Val                  10 15 20 gca gtg gga ttg tca ctg acc ttt gga cag atg ggc gtt att aat atg 211 Ala Val Gly Leu Ser Leu Thr Phe Gly Gln Met Gly Val Ile Asn Met              25 30 35 gcg cac gga gag ttc atc atg gtc ggc gca tac acc gca tat gtg gtg 259 Ala His Gly Glu Phe Ile Met Val Gly Ala Tyr Thr Ala Tyr Val Val          40 45 50 cag ctg gtc gtc ggt tct gcc ggt tta tcc cta ctg atc agc att ccg 307 Gln Leu Val Val Gly Ser Ala Gly Leu Ser Leu Leu Ile Ser Ile Pro      55 60 65 ctg gcc ttt att atc ggt ggg ctt ttc gga gtt ctc ctc gaa caa ttc 355 Leu Ala Phe Ile Ile Gly Gly Leu Phe Gly Val Leu Leu Glu Gln Phe  70 75 80 85 ctg ctg aag tat ctt tat cac agg cca cta gac acg ctg ctg gcc aca 403 Leu Leu Lys Tyr Leu Tyr His Arg Pro Leu Asp Thr Leu Leu Ala Thr                  90 95 100 ttc ggt gtc ggt ttg atc ctt cag cag ctg gcc cga aac att ttc gga 451 Phe Gly Val Gly Leu Ile Leu Gln Gln Leu Ala Arg Asn Ile Phe Gly             105 110 115 gct ccc gca gtg gat gtc agg gca ccg gaa ttt ctc cgc gga aac gtc 499 Ala Pro Ala Val Asp Val Arg Ala Pro Glu Phe Leu Arg Gly Asn Val         120 125 130 gaa gtt cta ggc gtc ttg gtg ccg acc gcg cga cta ttc atc ctg gcg 547 Glu Val Leu Gly Val Leu Val Pro Thr Ala Arg Leu Phe Ile Leu Ala     135 140 145 ctg gcc atc gca tca gtg act gca cta gct gtg ttc cta aat cgc act 595 Leu Ala Ile Ala Ser Val Thr Ala Leu Ala Val Phe Leu Asn Arg Thr 150 155 160 165 gcc tgg ggc cga cgc atc cgc gcc gtg gtt ctg aac cgc gac ctc gcg 643 Ala Trp Gly Arg Arg Ile Arg Ala Val Val Leu Asn Arg Asp Leu Ala                 170 175 180 gaa acc gca ggt att gat acc cga gct act gac cga atg acg ttc ttt 691 Glu Thr Ala Gly Ile Asp Thr Arg Ala Thr Asp Arg Met Thr Phe Phe             185 190 195 gtg ggc tcc ggt ctt gcc gga atc gcc ggg gta gct atc aca ttg att 739 Val Gly Ser Gly Leu Ala Gly Ile Ala Gly Val Ala Ile Thr Leu Ile         200 205 210 ggc gcg acc ggc ccc acc atc ggt cag aac tac atc gtg gat gcc ttc 787 Gly Ala Thr Gly Pro Thr Ile Gly Gln Asn Tyr Ile Val Asp Ala Phe     215 220 225 ctt gtt gtt gcc gcc ggt ggc atc ggc cgg gtg aag ggc gct gtg atc 835 Leu Val Val Ala Ala Gly Gly Ile Gly Arg Val Lys Gly Ala Val Ile 230 235 240 245 atg gct ttc gtg ctg gga att act caa gca ttc gtg gaa tat acg aca 883 Met Ala Phe Val Leu Gly Ile Thr Gln Ala Phe Val Glu Tyr Thr Thr                 250 255 260 ggt gcg agc atc gcg aag ttc atc gta ctc atc gct gtt gtt gcc ttc 931 Gly Ala Ser Ile Ala Lys Phe Ile Val Leu Ile Ala Val Val Ala Phe             265 270 275 ctg cag ttt agg cct caa gga ctc ttc caa acc caa act agg agc ctc 979 Leu Gln Phe Arg Pro Gln Gly Leu Phe Gln Thr Gln Thr Arg Ser Leu         280 285 290 gta tgagcactca actcaagctg aag 1005 Val <210> 464 <211> 294 <212> PRT <213> Corynebacterium glutamicum <400> 464 Met Asp Ile Leu Leu Asn Gln Leu Val Ala Gly Leu Ser Val Gly Ser   1 5 10 15 Val Leu Leu Leu Val Ala Val Gly Leu Ser Leu Thr Phe Gly Gln Met              20 25 30 Gly Val Ile Asn Met Ala His Gly Glu Phe Ile Met Val Gly Ala Tyr          35 40 45 Thr Ala Tyr Val Val Gln Leu Val Val Gly Ser Ala Gly Leu Ser Leu      50 55 60 Leu Ile Ser Ile Pro Leu Ala Phe Ile Ile Gly Gly Leu Phe Gly Val  65 70 75 80 Leu Leu Glu Gln Phe Leu Leu Lys Tyr Leu Tyr His Arg Pro Leu Asp                  85 90 95 Thr Leu Leu Ala Thr Phe Gly Val Gly Leu Ile Leu Gln Gln Leu Ala             100 105 110 Arg Asn Ile Phe Gly Ala Pro Ala Val Asp Val Arg Ala Pro Glu Phe         115 120 125 Leu Arg Gly Asn Val Glu Val Leu Gly Val Leu Val Pro Thr Ala Arg     130 135 140 Leu Phe Ile Leu Ala Leu Ala Ile Ala Ser Val Thr Ala Leu Ala Val 145 150 155 160 Phe Leu Asn Arg Thr Ala Trp Gly Arg Arg Ile Arg Ala Val Val Leu                 165 170 175 Asn Arg Asp Leu Ala Glu Thr Ala Gly Ile Asp Thr Arg Ala Thr Asp             180 185 190 Arg Met Thr Phe Phe Val Gly Ser Gly Leu Ala Gly Ile Ala Gly Val         195 200 205 Ala Ile Thr Leu Ile Gly Ala Thr Gly Pro Thr Ile Gly Gln Asn Tyr     210 215 220 Ile Val Asp Ala Phe Leu Val Val Ala Ala Gly Gly Ile Gly Arg Val 225 230 235 240 Lys Gly Ala Val Ile Met Ala Phe Val Leu Gly Ile Thr Gln Ala Phe                 245 250 255 Val Glu Tyr Thr Thr Gly Ala Ser Ile Ala Lys Phe Ile Val Leu Ile             260 265 270 Ala Val Val Ala Phe Leu Gln Phe Arg Pro Gln Gly Leu Phe Gln Thr         275 280 285 Gln Thr Arg Ser Leu Val     290 <210> 465 <211> 1200 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1177) <223> RXA01220 <400> 465 caggtgcgag catcgcgaag ttcatcgtac tcatcgctgt tgttgccttc ctgcagttta 60 ggcctcaagg actcttccaa acccaaacta ggagcctcgt atg agc act caa ctc 115                                             Met Ser Thr Gln Leu                                               1 5 aag ctg aag aag ccc gca aag aag aaa act acg ccg aaa ctt agc gtc 163 Lys Leu Lys Lys Pro Ala Lys Lys Lys Thr Thr Pro Lys Leu Ser Val                  10 15 20 gta aat gct ccc acg ctg cgc act gcg gcg ttg ggc ctg gcc gcg ctc 211 Val Asn Ala Pro Thr Leu Arg Thr Ala Ala Leu Gly Leu Ala Ala Leu              25 30 35 gct gcg gta ttg ctg tgc gcc ccg ctc ttt tta tcc aca ttc cag ctg 259 Ala Ala Val Leu Leu Cys Ala Pro Leu Phe Leu Ser Thr Phe Gln Leu          40 45 50 acg ttg atg tcg cgc ttg gtg tgt tat gcg atc gtc gca gtc ggc atc 307 Thr Leu Met Ser Arg Leu Val Cys Tyr Ala Ile Val Ala Val Gly Ile      55 60 65 ggg ctg gcg tgg ggc aga ggc ggc atg ctc acg ctg ggg caa ggc gtg 355 Gly Leu Ala Trp Gly Arg Gly Gly Met Leu Thr Leu Gly Gln Gly Val  70 75 80 85 ttc ttt gga atc ggc gcg tac atc atg gcc atg cac atg ctg tac agc 403 Phe Phe Gly Ile Gly Ala Tyr Ile Met Ala Met His Met Leu Tyr Ser                  90 95 100 gat tcg cag att ttt ggg acc aca gtt ccg caa tgg tgg tcc att ttt 451 Asp Ser Gln Ile Phe Gly Thr Thr Val Pro Gln Trp Trp Ser Ile Phe             105 110 115 gcc aac ccg gca gtc gca ctc atc gca gtt gtg gcg ctt ccc ggc atc 499 Ala Asn Pro Ala Val Ala Leu Ile Ala Val Val Ala Leu Pro Gly Ile         120 125 130 gtg gct ttt gtg ctc ggc ttc tcc att ttc aaa cga cgc atc aaa ggc 547 Val Ala Phe Val Leu Gly Phe Ser Ile Phe Lys Arg Arg Ile Lys Gly     135 140 145 gcc tac ttt gcc atc gtg aac caa gcg ctc gcc gca gct gtt gtg gtg 595 Ala Tyr Phe Ala Ile Val Asn Gln Ala Leu Ala Ala Ala Val Val Val 150 155 160 165 ttg ctg gtc gga caa caa gat tcc ctt gga ggt tcc aat ggt ctt tcc 643 Leu Leu Val Gly Gln Gln Asp Ser Leu Gly Gly Ser Asn Gly Leu Ser                 170 175 180 gga ttt cga tcg ttc atg ggt ttt gcc gtc tac gac ccc atc aac cgc 691 Gly Phe Arg Ser Phe Met Gly Phe Ala Val Tyr Asp Pro Ile Asn Arg             185 190 195 atc atg ttt tac ttc acc gca gtg gga gtt ctc ttg gct ttg gtg gct 739 Ile Met Phe Tyr Phe Thr Ala Val Gly Val Leu Leu Ala Leu Val Ala         200 205 210 atc tca tat tgg ctc atg cgc agc cgc tat gga gaa ctg ctc gtg gcc 787 Ile Ser Tyr Trp Leu Met Arg Ser Arg Tyr Gly Glu Leu Leu Val Ala     215 220 225 acc aga gat gca gaa gaa cgc gtc cga ttc ctc gga tat gat ccc gca 835 Thr Arg Asp Ala Glu Glu Arg Val Arg Phe Leu Gly Tyr Asp Pro Ala 230 235 240 245 ttg atc aaa acc gcc gca tat gtc att gct gcg atg att gcc gga atc 883 Leu Ile Lys Thr Ala Ala Tyr Val Ile Ala Ala Met Ile Ala Gly Ile                 250 255 260 gcc gga gcg ctg ttc gtg ccg atc gtg ggc atc att tca ccc gca gaa 931 Ala Gly Ala Leu Phe Val Pro Ile Val Gly Ile Ile Ser Pro Ala Glu             265 270 275 atc ggc gtg gtg cca tca atc gtg ttc gtg atc gcc gtc gcc gct ggt 979 Ile Gly Val Val Pro Ser Ile Val Phe Val Ile Ala Val Ala Ala Gly         280 285 290 ggc agg gca tcc cta ttc ggt ccc gta gtt ggc gcg ctg gtg ctg ggc 1027 Gly Arg Ala Ser Leu Phe Gly Pro Val Val Gly Ala Leu Val Leu Gly     295 300 305 tgg gtg gaa tcc aca ctt gct caa act ttc ccc agc atg tgg tcc tat 1075 Trp Val Glu Ser Thr Leu Ala Gln Thr Phe Pro Ser Met Trp Ser Tyr 310 315 320 325 ttc cag ggt gcg atc ctg gtt ctc gtg atc gtg ttg ctg ccg ggc gga 1123 Phe Gln Gly Ala Ile Leu Val Leu Val Ile Val Leu Leu Pro Gly Gly                 330 335 340 att gct tca att aaa ctt tcc gcg ctc aaa aat aag gcc agg aag gcc 1171 Ile Ala Ser Ile Lys Leu Ser Ala Leu Lys Asn Lys Ala Arg Lys Ala             345 350 355 acc tca tgagccttaa aatcaccaac ctc 1200 Thr ser <210> 466 <211> 359 <212> PRT <213> Corynebacterium glutamicum <400> 466 Met Ser Thr Gln Leu Lys Leu Lys Lys Pro Ala Lys Lys Lys Thr Thr   1 5 10 15 Pro Lys Leu Ser Val Val Asn Ala Pro Thr Leu Arg Thr Ala Ala Leu              20 25 30 Gly Leu Ala Ala Leu Ala Ala Val Leu Leu Cys Ala Pro Leu Phe Leu          35 40 45 Ser Thr Phe Gln Leu Thr Leu Met Ser Arg Leu Val Cys Tyr Ala Ile      50 55 60 Val Ala Val Gly Ile Gly Leu Ala Trp Gly Arg Gly Gly Met Leu Thr  65 70 75 80 Leu Gly Gln Gly Val Phe Phe Gly Ile Gly Ala Tyr Ile Met Ala Met                  85 90 95 His Met Leu Tyr Ser Asp Ser Gln Ile Phe Gly Thr Thr Val Pro Gln             100 105 110 Trp Trp Ser Ile Phe Ala Asn Pro Ala Val Ala Leu Ile Ala Val Val         115 120 125 Ala Leu Pro Gly Ile Val Ala Phe Val Leu Gly Phe Ser Ile Phe Lys     130 135 140 Arg Arg Ile Lys Gly Ala Tyr Phe Ala Ile Val Asn Gln Ala Leu Ala 145 150 155 160 Ala Ala Val Val Val Leu Leu Val Gly Gln Gln Asp Ser Leu Gly Gly                 165 170 175 Ser Asn Gly Leu Ser Gly Phe Arg Ser Phe Met Gly Phe Ala Val Tyr             180 185 190 Asp Pro Ile Asn Arg Ile Met Phe Tyr Phe Thr Ala Val Gly Val Leu         195 200 205 Leu Ala Leu Val Ala Ile Ser Tyr Trp Leu Met Arg Ser Arg Tyr Gly     210 215 220 Glu Leu Leu Val Ala Thr Arg Asp Ala Glu Glu Arg Val Arg Phe Leu 225 230 235 240 Gly Tyr Asp Pro Ala Leu Ile Lys Thr Ala Ala Tyr Val Ile Ala Ala                 245 250 255 Met Ile Ala Gly Ile Ala Gly Ala Leu Phe Val Pro Ile Val Gly Ile             260 265 270 Ile Ser Pro Ala Glu Ile Gly Val Val Pro Ser Ile Val Phe Val Ile         275 280 285 Ala Val Ala Ala Gly Gly Arg Ala Ser Leu Phe Gly Pro Val Val Gly     290 295 300 Ala Leu Val Leu Gly Trp Val Glu Ser Thr Leu Ala Gln Thr Phe Pro 305 310 315 320 Ser Met Trp Ser Tyr Phe Gln Gly Ala Ile Leu Val Leu Val Ile Val                 325 330 335 Leu Leu Pro Gly Gly Ile Ala Ser Ile Lys Leu Ser Ala Leu Lys Asn             340 345 350 Lys Ala Arg Lys Ala Thr Ser         355 <210> 467 <211> 876 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (101) .. (853) <223> RXA00091 <400> 467 tcatgaacca cgtgttccgc gcacaaggcg tcgtgtccat cattattgag atggtcggcg 60 gtaccgtctt cctcatcgtc atcctcagaa agggcagact gtg att acg tta act 115                                             Val Ile Thr Leu Thr                                               1 5 aat gtc cgc aag gaa tac tcc agc gac gtt gcc atc ggc ccc gtc aac 163 Asn Val Arg Lys Glu Tyr Ser Ser Asp Val Ala Ile Gly Pro Val Asn                  10 15 20 ctt gag atc cca gcc ggc ggc atc acc gcg ttg gtc ggc cca aac ggt 211 Leu Glu Ile Pro Ala Gly Gly Ile Thr Ala Leu Val Gly Pro Asn Gly              25 30 35 gca ggc aag tca aca ctg ctc acc atg atc ggt cga ctc ctc ggc atc 259 Ala Gly Lys Ser Thr Leu Leu Thr Met Ile Gly Arg Leu Leu Gly Ile          40 45 50 gat gaa ggc aac atc acc gta gcc tcc tac gat gtc acc tca acc gca 307 Asp Glu Gly Asn Ile Thr Val Ala Ser Tyr Asp Val Thr Ser Thr Ala      55 60 65 tcc aaa gat ctg gcc aag atc atc tcc atc ctg cgc cag gaa aac cac 355 Ser Lys Asp Leu Ala Lys Ile Ile Ser Ile Leu Arg Gln Glu Asn His  70 75 80 85 ttt gtt acc aag ctg acc gtg cgc cag ctc gta ggt ttc gga cgc ttc 403 Phe Val Thr Lys Leu Thr Val Arg Gln Leu Val Gly Phe Gly Arg Phe                  90 95 100 cca tat agc aag ggc cgg ctg acg gaa gaa gac gag gga atc atc tcc 451 Pro Tyr Ser Lys Gly Arg Leu Thr Glu Glu Asp Glu Gly Ile Ile Ser             105 110 115 cgc tac atc gac ttc ttc aat ctc acc gaa ctc gaa gac cgc tac ctc 499 Arg Tyr Ile Asp Phe Phe Asn Leu Thr Glu Leu Glu Asp Arg Tyr Leu         120 125 130 gac cag ctt tcc ggc ggc cag cgc cag cgc gcc tat gtc gcc atg gtg 547 Asp Gln Leu Ser Gly Gly Gln Arg Gln Arg Ala Tyr Val Ala Met Val     135 140 145 ctg tgc caa gag acg gac tac gtg ctt ctc gac gaa ccc ctc aac aat 595 Leu Cys Gln Glu Thr Asp Tyr Val Leu Leu Asp Glu Pro Leu Asn Asn 150 155 160 165 ctt gat atc gca cac tcg gtg gaa atg atg aaa cac ctc gag aat gct 643 Leu Asp Ile Ala His Ser Val Glu Met Met Lys His Leu Glu Asn Ala                 170 175 180 gca gcc caa ttt ggc cgc acc atc atc gtg gtt ctt cac gac atc aac 691 Ala Ala Gln Phe Gly Arg Thr Ile Ile Val Val Leu His Asp Ile Asn             185 190 195 ttc gcc gcg cgc tac gcc gat tac atc gtg gcc gta aag cac gga atg 739 Phe Ala Ala Arg Tyr Ala Asp Tyr Ile Val Ala Val Lys His Gly Met         200 205 210 atc gaa aaa gag gga aca cct gaa cag atc atg aaa aac gag atc ctt 787 Ile Glu Lys Glu Gly Thr Pro Glu Gln Ile Met Lys Asn Glu Ile Leu     215 220 225 tca gaa atc ttc aat aca gag atc gaa gtt att gaa gga cca cac ggc 835 Ser Glu Ile Phe Asn Thr Glu Ile Glu Val Ile Glu Gly Pro His Gly 230 235 240 245 aag att gct tgc tac cac taaatgaaga gaaataagcc gac 876 Lys Ile Ala Cys Tyr His                 250 <210> 468 <211> 251 <212> PRT <213> Corynebacterium glutamicum <400> 468 Val Ile Thr Leu Thr Asn Val Arg Lys Glu Tyr Ser Ser Asp Val Ala   1 5 10 15 Ile Gly Pro Val Asn Leu Glu Ile Pro Ala Gly Gly Ile Thr Ala Leu              20 25 30 Val Gly Pro Asn Gly Ala Gly Lys Ser Thr Leu Leu Thr Met Ile Gly          35 40 45 Arg Leu Leu Gly Ile Asp Glu Gly Asn Ile Thr Val Ala Ser Tyr Asp      50 55 60 Val Thr Ser Thr Ala Ser Lys Asp Leu Ala Lys Ile Ile Ser Ile Leu  65 70 75 80 Arg Gln Glu Asn His Phe Val Thr Lys Leu Thr Val Arg Gln Leu Val                  85 90 95 Gly Phe Gly Arg Phe Pro Tyr Ser Lys Gly Arg Leu Thr Glu Glu Asp             100 105 110 Glu Gly Ile Ile Ser Arg Tyr Ile Asp Phe Phe Asn Leu Thr Glu Leu         115 120 125 Glu Asp Arg Tyr Leu Asp Gln Leu Ser Gly Gly Gln Arg Gln Arg Ala     130 135 140 Tyr Val Ala Met Val Leu Cys Gln Glu Thr Asp Tyr Val Leu Leu Asp 145 150 155 160 Glu Pro Leu Asn Asn Leu Asp Ile Ala His Ser Val Glu Met Met Lys                 165 170 175 His Leu Glu Asn Ala Ala Ala Gln Phe Gly Arg Thr Ile Ile Val Val             180 185 190 Leu His Asp Ile Asn Phe Ala Ala Arg Tyr Ala Asp Tyr Ile Val Ala         195 200 205 Val Lys His Gly Met Ile Glu Lys Glu Gly Thr Pro Glu Gln Ile Met     210 215 220 Lys Asn Glu Ile Leu Ser Glu Ile Phe Asn Thr Glu Ile Glu Val Ile 225 230 235 240 Glu Gly Pro His Gly Lys Ile Ala Cys Tyr His                 245 250 <210> 469 <211> 692 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (79) .. (669) <223> RXA00228 <400> 469 ccgcatggca tccgccgaaa gaattcccct ccggaggaat ggcacgcctc atgggagaac 60 gcatcggcaa aaactgac atg cgc gac ctc cgc tcc atg atc ggc gtc agc 111                     Met Arg Asp Leu Arg Ser Met Ile Gly Val Ser                       1 5 10 tcc tcc gca tta ggc aac cga atc ccc tcc gaa gaa aaa gtc tct gac 159 Ser Ser Ala Leu Gly Asn Arg Ile Pro Ser Glu Glu Lys Val Ser Asp              15 20 25 cta gtc atc tcc gca ggc tac gca atc ctc ggc cgc tgg cgc gaa gac 207 Leu Val Ile Ser Ala Gly Tyr Ala Ile Leu Gly Arg Trp Arg Glu Asp          30 35 40 tac gac gaa atg gac ttc gga caa gcc acc gaa atc ctc gaa caa gtc 255 Tyr Asp Glu Met Asp Phe Gly Gln Ala Thr Glu Ile Leu Glu Gln Val      45 50 55 gga gcc atg cac cta gcc gac cgc acc tgg gga acc ctc tcc gaa ggc 303 Gly Ala Met His Leu Ala Asp Arg Thr Trp Gly Thr Leu Ser Glu Gly  60 65 70 75 gaa cgc aaa cga gtc ctg gtc gca cgc gca ctc atg acc aac ccg gaa 351 Glu Arg Lys Arg Val Leu Val Ala Arg Ala Leu Met Thr Asn Pro Glu                  80 85 90 ctc ctc atc ctt gac gaa cca acc gca gga atg gac ctc ggc gga cgc 399 Leu Leu Ile Leu Asp Glu Pro Thr Ala Gly Met Asp Leu Gly Gly Arg              95 100 105 gaa gac ctc gtc ggc tac ctc gga gaa ctc gcc atg gac cca gac gca 447 Glu Asp Leu Val Gly Tyr Leu Gly Glu Leu Ala Met Asp Pro Asp Ala         110 115 120 cct gcc atc gtc atg atc acc cac cac gtc gaa gaa atc ccc gcc gga 495 Pro Ala Ile Val Met Ile Thr His His Val Glu Glu Ile Pro Ala Gly     125 130 135 ttc acc cac gca atg ctc ctc gac gaa ggt gaa atc gta gcc caa ggc 543 Phe Thr His Ala Met Leu Leu Asp Glu Gly Glu Ile Val Ala Gln Gly 140 145 150 155 ctg atc aac acc gtc atg aca aac gag aac cta tcc aaa gca ttc cac 591 Leu Ile Asn Thr Val Met Thr Asn Glu Asn Leu Ser Lys Ala Phe His                 160 165 170 cag cca atc caa gta gac cgc atc ggg gaa cgc tac ttt gcc cgc cgt 639 Gln Pro Ile Gln Val Asp Arg Ile Gly Glu Arg Tyr Phe Ala Arg Arg             175 180 185 gtg aga acc gcc agg agt cat agg gct cag taggtttttt ggagttgtgg 689 Val Arg Thr Ala Arg Ser His Arg Ala Gln         190 195 gcc 692 <210> 470 <211> 197 <212> PRT <213> Corynebacterium glutamicum <400> 470 Met Arg Asp Leu Arg Ser Met Ile Gly Val Ser Ser Ser Ala Leu Gly   1 5 10 15 Asn Arg Ile Pro Ser Glu Glu Lys Val Ser Asp Leu Val Ile Ser Ala              20 25 30 Gly Tyr Ala Ile Leu Gly Arg Trp Arg Glu Asp Tyr Asp Glu Met Asp          35 40 45 Phe Gly Gln Ala Thr Glu Ile Leu Glu Gln Val Gly Ala Met His Leu      50 55 60 Ala Asp Arg Thr Trp Gly Thr Leu Ser Glu Gly Glu Arg Lys Arg Val  65 70 75 80 Leu Val Ala Arg Ala Leu Met Thr Asn Pro Glu Leu Leu Ile Leu Asp                  85 90 95 Glu Pro Thr Ala Gly Met Asp Leu Gly Gly Arg Glu Asp Leu Val Gly             100 105 110 Tyr Leu Gly Glu Leu Ala Met Asp Pro Asp Ala Pro Ala Ile Val Met         115 120 125 Ile Thr His His Val Glu Glu Ile Pro Ala Gly Phe Thr His Ala Met     130 135 140 Leu Leu Asp Glu Gly Glu Ile Val Ala Gln Gly Leu Ile Asn Thr Val 145 150 155 160 Met Thr Asn Glu Asn Leu Ser Lys Ala Phe His Gln Pro Ile Gln Val                 165 170 175 Asp Arg Ile Gly Glu Arg Tyr Phe Ala Arg Arg Val Arg Thr Ala Arg             180 185 190 Ser His Arg Ala Gln         195 <210> 471 <211> 813 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (790) <223> RXA00346 <400> 471 atctatgaga cccctcaaaa caccgagaat ttcctcgatg cattcaccaa ggcagttgat 60 gatctcaccg ctgccactaa ccaggtttag aattatttaa atg ctg ttg act ttc 115                                             Met Leu Leu Thr Phe                                               1 5 aat gat gct gcg gtg gat ccc ctc tgg agg ggc ctg aat tta gag ctc 163 Asn Asp Ala Ala Val Asp Pro Leu Trp Arg Gly Leu Asn Leu Glu Leu                  10 15 20 cga cag ggg gaa ttt ctt gcg gtt tta ggc ccc aac ggc gtg gga aaa 211 Arg Gln Gly Glu Phe Leu Ala Val Leu Gly Pro Asn Gly Val Gly Lys              25 30 35 tcc acg ctc atc ggt acg att ttg ggc acc cga aaa ctc acc cac ggt 259 Ser Thr Leu Ile Gly Thr Ile Leu Gly Thr Arg Lys Leu Thr His Gly          40 45 50 tcg gtt aaa act gat gcc cgg gtg ggt tat att ccg caa caa cga att 307 Ser Val Lys Thr Asp Ala Arg Val Gly Tyr Ile Pro Gln Gln Arg Ile      55 60 65 ttc gat gtc ccg ttg cgt gcc cgc gat atg gtt tcg ctg tcc gcg gcg 355 Phe Asp Val Pro Leu Arg Ala Arg Asp Met Val Ser Leu Ser Ala Ala  70 75 80 85 cat ggc gtg gtt tcc aaa agg gga ccc gcg aag ggt gac gtc gat aag 403 His Gly Val Val Ser Lys Arg Gly Pro Ala Lys Gly Asp Val Asp Lys                  90 95 100 ctt ctt gcc cgc gtg ggc gct tcc gga atc gcc gat cga cgc gtc ggc 451 Leu Leu Ala Arg Val Gly Ala Ser Gly Ile Ala Asp Arg Arg Val Gly             105 110 115 gag ctc tcc ggc ggg cag cag cag ctc gtc cgc caa gcc cag gcc ctt 499 Glu Leu Ser Gly Gly Gln Gln Gln Leu Val Arg Gln Ala Gln Ala Leu         120 125 130 gcc acg cgc ccg caa tta ttg ctt gcc gac gaa ccc ctc ctc agc ctt 547 Ala Thr Arg Pro Gln Leu Leu Leu Ala Asp Glu Pro Leu Leu Ser Leu     135 140 145 gac ccc ggc gtc gcg cag cgc acg gtg tcc cta ttt ggt gaa ttg aag 595 Asp Pro Gly Val Ala Gln Arg Thr Val Ser Leu Phe Gly Glu Leu Lys 150 155 160 165 gcc gaa ggc gtc ggc gtt gtt gtg gtc acc cac gat gtc aat cca cta 643 Ala Glu Gly Val Gly Val Val Val Thr His Asp Val Asn Pro Leu                 170 175 180 atg ggc ctg gta gat cgc att ttg tac ctc gcc ccc aac ggc cac acc 691 Met Gly Leu Val Asp Arg Ile Leu Tyr Leu Ala Pro Asn Gly His Thr             185 190 195 atc ggc acg gtt ggc gat gtc atg cag tcc gaa aaa ctc agc gaa ctc 739 Ile Gly Thr Val Gly Asp Val Met Gln Ser Glu Lys Leu Ser Glu Leu         200 205 210 tac aac gca ccc gtc acg gtg gct cgc atc aac gac aga atc gtg gtg 787 Tyr Asn Ala Pro Val Thr Val Ala Arg Ile Asn Asp Arg Ile Val Val     215 220 225 gtt taagtggatc tatccacctg gct 813 Val 230 <210> 472 <211> 230 <212> PRT <213> Corynebacterium glutamicum <400> 472 Met Leu Leu Thr Phe Asn Asp Ala Ala Val Asp Pro Leu Trp Arg Gly   1 5 10 15 Leu Asn Leu Glu Leu Arg Gln Gly Glu Phe Leu Ala Val Leu Gly Pro              20 25 30 Asn Gly Val Gly Lys Ser Thr Leu Ile Gly Thr Ile Leu Gly Thr Arg          35 40 45 Lys Leu Thr His Gly Ser Val Lys Thr Asp Ala Arg Val Gly Tyr Ile      50 55 60 Pro Gln Gln Arg Ile Phe Asp Val Pro Leu Arg Ala Arg Asp Met Val  65 70 75 80 Ser Leu Ser Ala Ala His Gly Val Val Ser Lys Arg Gly Pro Ala Lys                  85 90 95 Gly Asp Val Asp Lys Leu Leu Ala Arg Val Gly Ala Ser Gly Ile Ala             100 105 110 Asp Arg Arg Val Gly Glu Leu Ser Gly Gly Gln Gln Gln Leu Val Arg         115 120 125 Gln Ala Gln Ala Leu Ala Thr Arg Pro Gln Leu Leu Leu Ala Asp Glu     130 135 140 Pro Leu Leu Ser Leu Asp Pro Gly Val Ala Gln Arg Thr Val Ser Leu 145 150 155 160 Phe Gly Glu Leu Lys Ala Glu Gly Val Gly Val Val Val Val Thr His                 165 170 175 Asp Val Asn Pro Leu Met Gly Leu Val Asp Arg Ile Leu Tyr Leu Ala             180 185 190 Pro Asn Gly His Thr Ile Gly Thr Val Gly Asp Val Met Gln Ser Glu         195 200 205 Lys Leu Ser Glu Leu Tyr Asn Ala Pro Val Thr Val Ala Arg Ile Asn     210 215 220 Asp Arg Ile Val Val Val 225 230 <210> 473 <211> 433 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <101> (101) .. (433) <223> RXA00524 <400> 473 tcctcggcac ccgctacccc gtcggagttg tcaccggcgc attcggcgcc ccattcctta 60 tctatttact cattcgttcc aaccgcgcgg gagtaaccct gtg acc acc aac cat 115                                             Val Thr Thr Asn His                                               1 5 caa cta tcc gcc gaa gaa att tcc ctg gcg tac ggc gag cgc acc atc 163 Gln Leu Ser Ala Glu Glu Ile Ser Leu Ala Tyr Gly Glu Arg Thr Ile                  10 15 20 atc gat tcg ctc agc gtc gac atc gtc ccc ggc aaa atc acc tcc atc 211 Ile Asp Ser Leu Ser Val Asp Ile Val Pro Gly Lys Ile Thr Ser Ile              25 30 35 gtc ggc ccc aac gga tgc ggc aaa tca acg ctg ctg cgc gcc ttt gcg 259 Val Gly Pro Asn Gly Cys Gly Lys Ser Thr Leu Leu Arg Ala Phe Ala          40 45 50 cgc ctc ctt aaa cct agc gcc ggg caa gcg ctt atc gac gcc cac ccc 307 Arg Leu Leu Lys Pro Ser Ala Gly Gln Ala Leu Ile Asp Ala His Pro      55 60 65 ctt cct tca ctg cca ggc aaa gaa cta gct cgc atg ctc ggg ctg tta 355 Leu Pro Ser Leu Pro Gly Lys Glu Leu Ala Arg Met Leu Gly Leu Leu  70 75 80 85 ccg caa tcc ccc acc gga cct gaa ggc atc gtc gtc gcc gac ctc gtg 403 Pro Gln Ser Pro Thr Gly Pro Glu Gly Ile Val Val Ala Asp Leu Val                  90 95 100 ggc cgc ggc cgc cac ccc cac caa gga ctc 433 Gly Arg Gly Arg His Pro His Gln Gly Leu             105 110 <210> 474 <211> 111 <212> PRT <213> Corynebacterium glutamicum <400> 474 Val Thr Thr Asn His Gln Leu Ser Ala Glu Glu Ile Ser Leu Ala Tyr   1 5 10 15 Gly Glu Arg Thr Ile Ile Asp Ser Leu Ser Val Asp Ile Val Pro Gly              20 25 30 Lys Ile Thr Ser Ile Val Gly Pro Asn Gly Cys Gly Lys Ser Thr Leu          35 40 45 Leu Arg Ala Phe Ala Arg Leu Leu Lys Pro Ser Ala Gly Gln Ala Leu      50 55 60 Ile Asp Ala His Pro Leu Pro Ser Leu Pro Gly Lys Glu Leu Ala Arg  65 70 75 80 Met Leu Gly Leu Leu Pro Gln Ser Pro Thr Gly Pro Glu Gly Ile Val                  85 90 95 Val Ala Asp Leu Val Gly Arg Gly Arg His Pro His Gln Gly Leu             100 105 110 <210> 475 <211> 900 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (877) <223> RXA01823 <400> 475 gcaacacgtt gatactgagc tgcacacgcc cgttggcctg gtgaccagtt tgctgggcgg 60 ggtgtatttg atgtggcttt tgagccgaaa ggaggcataa atg ctg caa gcg cat 115                                             Met Leu Gln Ala His                                               1 5 gat ctc acg ctg agt tac ggc ggg cga aat att gta gaa ggg ctc agt 163 Asp Leu Thr Leu Ser Tyr Gly Gly Arg Asn Ile Val Glu Gly Leu Ser                  10 15 20 ctg gac ctt ccg gaa aga ggc ctc agc atc atc att ggc ccc aac gga 211 Leu Asp Leu Pro Glu Arg Gly Leu Ser Ile Ile Ile Gly Pro Asn Gly              25 30 35 tgc ggg aaa tca acc gtt ttg aaa gcg ttg ggc aga ctg ctg aaa cca 259 Cys Gly Lys Ser Thr Val Leu Lys Ala Leu Gly Arg Leu Leu Lys Pro          40 45 50 caa ttg ggg aag atc acg cta ggt ggg cga gat att tcc agc atg ggc 307 Gln Leu Gly Lys Ile Thr Leu Gly Gly Arg Asp Ile Ser Ser Met Gly      55 60 65 acc aag cat gtg gcg aaa cac atc ggg gtg ctt ccg caa ccc cca tat 355 Thr Lys His Val Ala Lys His Ile Gly Val Leu Pro Gln Pro Pro Tyr  70 75 80 85 gcg ccc gat ggg gtg agc gtc acg gag ctg gtc agc cgc ggg cgg tat 403 Ala Pro Asp Gly Val Ser Val Thr Glu Leu Val Ser Arg Gly Arg Tyr                  90 95 100 ccg cac caa cat ctg ctg tcg caa tgg tcg aaa gac gat gaa gcc att 451 Pro His Gln His Leu Leu Ser Gln Trp Ser Lys Asp Asp Glu Ala Ile             105 110 115 gtg gcg cgc tcg ctg gcg gaa gtc ggc atg cac acc cat gct gag cat 499 Val Ala Arg Ser Leu Ala Glu Val Gly Met His Thr His Ala Glu His         120 125 130 tta gtg tcg gaa ctt tca ggc ggc cag cgc caa cgg gcg tgg atc gcc 547 Leu Val Ser Glu Leu Ser Gly Gly Gln Arg Gln Arg Ala Trp Ile Ala     135 140 145 atg gcg ctc gct cag gaa aca gac att ttg ctt ctc gac gag ccc acc 595 Met Ala Leu Ala Gln Glu Thr Asp Ile Leu Leu Leu Asp Glu Pro Thr 150 155 160 165 acg ttc ctc gac gta gcc cac caa ata tcc gtc ctc gat tta tgc tcc 643 Thr Phe Leu Asp Val Ala His Gln Ile Ser Val Leu Asp Leu Cys Ser                 170 175 180 gac ctg cac caa cgt ggt cgc acc ctg gcc att gtt cta cac gat ctg 691 Asp Leu His Gln Arg Gly Arg Thr Leu Ala Ile Val Leu His Asp Leu             185 190 195 aac atg gct gca cgg tat gcc acc cac atc atc gcc atg cgg gac ggc 739 Asn Met Ala Ala Arg Tyr Ala Thr His Ile Ile Ala Met Arg Asp Gly         200 205 210 acc atc atc gac caa gga aaa ccc gaa gaa ata ctc act aaa gcg ctg 787 Thr Ile Ile Asp Gln Gly Lys Pro Glu Glu Ile Leu Thr Lys Ala Leu     215 220 225 ctc aaa gaa gtt ttt gac ctc gac gca ctc atc ctc aaa gac ccc aac 835 Leu Lys Glu Val Phe Asp Leu Asp Ala Leu Ile Leu Lys Asp Pro Asn 230 235 240 245 aac ggc cga cca ctc atc gtg ccc aca gac agg aga aac tca 877 Asn Gly Arg Pro Leu Ile Val Pro Thr Asp Arg Arg Asn Ser                 250 255 tgaaagaaac cgacaaccta ctg 900 <210> 476 <211> 259 <212> PRT <213> Corynebacterium glutamicum <400> 476 Met Leu Gln Ala His Asp Leu Thr Leu Ser Tyr Gly Gly Arg Asn Ile   1 5 10 15 Val Glu Gly Leu Ser Leu Asp Leu Pro Glu Arg Gly Leu Ser Ile Ile              20 25 30 Ile Gly Pro Asn Gly Cys Gly Lys Ser Thr Val Leu Lys Ala Leu Gly          35 40 45 Arg Leu Leu Lys Pro Gln Leu Gly Lys Ile Thr Leu Gly Gly Arg Asp      50 55 60 Ile Ser Ser Met Gly Thr Lys His Val Ala Lys His Ile Gly Val Leu  65 70 75 80 Pro Gln Pro Pro Tyr Ala Pro Asp Gly Val Ser Val Thr Glu Leu Val                  85 90 95 Ser Arg Gly Arg Tyr Pro His Gln His Leu Leu Ser Gln Trp Ser Lys             100 105 110 Asp Asp Glu Ala Ile Val Ala Arg Ser Leu Ala Glu Val Gly Met His         115 120 125 Thr His Ala Glu His Leu Val Ser Glu Leu Ser Gly Gly Gln Arg Gln     130 135 140 Arg Ala Trp Ile Ala Met Ala Leu Ala Gln Glu Thr Asp Ile Leu Leu 145 150 155 160 Leu Asp Glu Pro Thr Thr Phe Leu Asp Val Ala His Gln Ile Ser Val                 165 170 175 Leu Asp Leu Cys Ser Asp Leu His Gln Arg Gly Arg Thr Leu Ala Ile             180 185 190 Val Leu His Asp Leu Asn Met Ala Ala Arg Tyr Ala Thr His Ile Ile         195 200 205 Ala Met Arg Asp Gly Thr Ile Ile Asp Gln Gly Lys Pro Glu Glu Ile     210 215 220 Leu Thr Lys Ala Leu Leu Lys Glu Val Phe Asp Leu Asp Ala Leu Ile 225 230 235 240 Leu Lys Asp Pro Asn Asn Gly Arg Pro Leu Ile Val Pro Thr Asp Arg                 245 250 255 Arg Asn Ser <210> 477 <211> 906 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (883) <223> RXA02767 <400> 477 gggaaaacgt ttcctcgccg cccacagaat cataaaaatt ttctgaggtt gtcatgggta 60 ccagtctaag ccctggcctt acgccagtaa ggtgttaccc atg cgc gaa cta gca 115                                             Met Arg Glu Leu Ala                                               1 5 ctc aac atg gcc ggc gtc acc gtg cgg cgc ggc gag aaa ttg ctt ctc 163 Leu Asn Met Ala Gly Val Thr Val Arg Arg Gly Glu Lys Leu Leu Leu                  10 15 20 gac gat atc tcc ctc tca att ccg caa ggg tcg cac tgg gcc gta ctt 211 Asp Asp Ile Ser Leu Ser Ile Pro Gln Gly Ser His Trp Ala Val Leu              25 30 35 ggt cca aat ggc gcc ggt aaa acc acc atg ctg aag atc gca gcc acc 259 Gly Pro Asn Gly Ala Gly Lys Thr Thr Met Leu Lys Ile Ala Ala Thr          40 45 50 ttg ctg tac cca tcg gaa ggc acc gtg gac atc ctg ggg cat cgc ttt 307 Leu Leu Tyr Pro Ser Glu Gly Thr Val Asp Ile Leu Gly His Arg Phe      55 60 65 ggt cgg gtg gat act cgt gag ctg cgg aaa aca atc ggc ctg gtg gac 355 Gly Arg Val Asp Thr Arg Glu Leu Arg Lys Thr Ile Gly Leu Val Asp  70 75 80 85 ccg aag caa aga ttt acc aac ctg ccg gcc cac gaa att gtg ctg tcg 403 Pro Lys Gln Arg Phe Thr Asn Leu Pro Ala His Glu Ile Val Leu Ser                  90 95 100 ggg tta acc gcc tcc aac ggg ttg ttg cca cgg tgg tcg gct tcg gct 451 Gly Leu Thr Ala Ser Asn Gly Leu Le Au Pro Arg Trp Ser Ala Ser Ala             105 110 115 tcg gag ttg gag cgg tgc gct ttg atg ttg gag ttg gtg ggc atg aca 499 Ser Glu Leu Glu Arg Cys Ala Leu Met Leu Glu Leu Val Gly Met Thr         120 125 130 gcg cgt gcc gat cgt tac tgg gcc gat atg agc cag ggc gaa aaa gcc 547 Ala Arg Ala Asp Arg Tyr Trp Ala Asp Met Ser Gln Gly Glu Lys Ala     135 140 145 cgc acc ctg att gct cgt gcg ctg att atc tca ccg acc cta ctg ctg 595 Arg Thr Leu Ile Ala Arg Ala Leu Ile Ile Ser Pro Thr Leu Leu Leu 150 155 160 165 ctt gat gaa ccc acc acc ggc ctt gac ctg ccc gga cgt gaa act ttg 643 Leu Asp Glu Pro Thr Thr Gly Leu Asp Leu Pro Gly Arg Glu Thr Leu                 170 175 180 ctc agt gtg att gat ggt ttg cga gcc gct ctt cct ggt ctg acg aca 691 Leu Ser Val Ile Asp Gly Leu Arg Ala Ala Leu Pro Gly Leu Thr Thr             185 190 195 gtg atg atc acc cac cac gtc gaa gag atc gcc gcc tcc acg aca gat 739 Val Met Ile Thr His His Val Glu Glu Ile Ala Ala Ser Thr Thr Asp         200 205 210 atc ctc atg atc aag gac gcc cgc ata ctg gct tcg ggg act gtt tca 787 Ile Leu Met Ile Lys Asp Ala Arg Ile Leu Ala Ser Gly Thr Val Ser     215 220 225 gaa gtg atg act cct gaa aat ttg ggc gcg ctg tat gac atg tcg gtg 835 Glu Val Met Thr Pro Glu Asn Leu Gly Ala Leu Tyr Asp Met Ser Val 230 235 240 245 tcg ttg gaa act gtg cgc agc cgg tgg ttc gcg ttc gat gct ctg cat 883 Ser Leu Glu Thr Val Arg Ser Arg Trp Phe Ala Phe Asp Ala Leu His                 250 255 260 taaaaggggc tagttttaca caa 906 <210> 478 <211> 261 <212> PRT <213> Corynebacterium glutamicum <400> 478 Met Arg Glu Leu Ala Leu Asn Met Ala Gly Val Thr Val Arg Arg Gly   1 5 10 15 Glu Lys Leu Leu Leu Asp Asp Ile Ser Leu Ser Ile Pro Gln Gly Ser              20 25 30 His Trp Ala Val Leu Gly Pro Asn Gly Ala Gly Lys Thr Thr Met Leu          35 40 45 Lys Ile Ala Ala Thr Leu Leu Tyr Pro Ser Glu Gly Thr Val Asp Ile      50 55 60 Leu Gly His Arg Phe Gly Arg Val Asp Thr Arg Glu Leu Arg Lys Thr  65 70 75 80 Ile Gly Leu Val Asp Pro Lys Gln Arg Phe Thr Asn Leu Pro Ala His                  85 90 95 Glu Ile Val Leu Ser Gly Leu Thr Ala Ser Asn Gly Leu Leu Pro Arg             100 105 110 Trp Ser Ala Ser Ala Ser Glu Leu Glu Arg Cys Ala Leu Met Leu Glu         115 120 125 Leu Val Gly Met Thr Ala Arg Ala Asp Arg Tyr Trp Ala Asp Met Ser     130 135 140 Gln Gly Glu Lys Ala Arg Thr Leu Ile Ala Arg Ala Leu Ile Ile Ser 145 150 155 160 Pro Thr Leu Leu Leu Leu Asp Glu Pro Thr Thr Gly Leu Asp Leu Pro                 165 170 175 Gly Arg Glu Thr Leu Leu Ser Val Ile Asp Gly Leu Arg Ala Ala Leu             180 185 190 Pro Gly Leu Thr Thr Val Val Ile Thr His His Val Glu Glu Ile Ala         195 200 205 Ala Ser Thr Thr Asp Ile Leu Met Ile Lys Asp Ala Arg Ile Leu Ala     210 215 220 Ser Gly Thr Val Ser Glu Val Met Thr Pro Glu Asn Leu Gly Ala Leu 225 230 235 240 Tyr Asp Met Ser Val Ser Leu Glu Thr Val Arg Ser Arg Trp Phe Ala                 245 250 255 Phe Asp Ala Leu His             260 <210> 479 <211> 876 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (101) .. (853) <223> RXA02792 <400> 479 agaacaaagt gctgcccata ctcatgaact ttgccgaacc cccaaccccg ctggccgtcg 60 atggcctaga aaaaatcatc gactttgtgg aaacccaccc atg atc gag gcc aca 115                                             Met Ile Glu Ala Thr                                               1 5 cac cta cgc cac agt ttt ggc gac aac atc gtc atc gat gac gtc acc 163 His Leu Arg His Ser Phe Gly Asp Asn Ile Val Ile Asp Asp Val Thr                  10 15 20 ctc cat cta cct gca cac ggc acc gtc agc ttg gtc ggc ccc aac ggc 211 Leu His Leu Pro Ala His Gly Thr Val Ser Leu Val Gly Pro Asn Gly              25 30 35 agt ggc aaa acc acc ctg ctg cgt gca cta tac gga gca ctg caa cca 259 Ser Gly Lys Thr Thr Leu Leu Arg Ala Leu Tyr Gly Ala Leu Gln Pro          40 45 50 aat gaa ggg cac atc cac gta gat ggc gtt cca cta ata agc ttg cac 307 Asn Glu Gly His Ile His Val Asp Gly Val Pro Leu Ile Ser Leu His      55 60 65 cgc aaa gac atc gca aaa acc atg gcc gta gtc atc caa gaa cat gac 355 Arg Lys Asp Ile Ala Lys Thr Met Ala Val Val Ile Gln Glu His Asp  70 75 80 85 tcc gac ctc ccc atg acc gtc gct gac ctg gtc tta cta ggc aga ctc 403 Ser Asp Leu Pro Met Thr Val Ala Asp Leu Val Leu Leu Gly Arg Leu                  90 95 100 ccc cac caa aag atg ttt gcc ggc aac tct caa gct gat cag tta ctc 451 Pro His Gln Lys Met Phe Ala Gly Asn Ser Gln Ala Asp Gln Leu Leu             105 110 115 gtt aag gaa gca ctc acc cga gtc ggc gcc att cac ctg gcc gac cga 499 Val Lys Glu Ala Leu Thr Arg Val Gly Ala Ile His Leu Ala Asp Arg         120 125 130 caa ttc ggc gca ctt tca ggc ggt gaa cgc caa cgc gtc ctc atc gca 547 Gln Phe Gly Ala Leu Ser Gly Gly Glu Arg Gln Arg Val Leu Ile Ala     135 140 145 cga gca ctc gta caa aac gcc aca cac att ctg ctc gac gaa ccc acc 595 Arg Ala Leu Val Gln Asn Ala Thr His Ile Leu Leu Asp Glu Pro Thr 150 155 160 165 aac cac ctc gac atc cgc tac cag cac gaa gtc ctt cac ctc gtc cgc 643 Asn His Leu Asp Ile Arg Tyr Gln His Glu Val Leu His Leu Val Arg                 170 175 180 gaa ctc agc tca agt tcc atc atc gtc ctc cac gac ctc aac ctc gca 691 Glu Leu Ser Ser Ser Ser Ile Val Leu His Asp Leu Asn Leu Ala             185 190 195 ggt gcc tac agc gac cac atc atc ctc ctt gac caa gga cgt gtg gtt 739 Gly Ala Tyr Ser Asp His Ile Ile Leu Leu Asp Gln Gly Arg Val Val         200 205 210 act caa gga acg ccc tca gag gta ttg acc cca gag cat ttg gaa cct 787 Thr Gln Gly Thr Pro Ser Glu Val Leu Thr Pro Glu His Leu Glu Pro     215 220 225 gtg tat ggc gtt cgt gtt gag cgc ttt gac cta ggc gat gaa gtc cac 835 Val Tyr Gly Val Arg Val Glu Arg Phe Asp Leu Gly Asp Glu Val His 230 235 240 245 ctt cgg ttc aag cgt cac taggagtttt gttgaggagg tgg 876 Leu Arg Phe Lys Arg His                 250 <210> 480 <211> 251 <212> PRT <213> Corynebacterium glutamicum <400> 480 Met Ile Glu Ala Thr His Leu Arg His Ser Phe Gly Asp Asn Ile Val   1 5 10 15 Ile Asp Asp Val Thr Leu His Leu Pro Ala His Gly Thr Val Ser Leu              20 25 30 Val Gly Pro Asn Gly Ser Gly Lys Thr Thr Leu Leu Arg Ala Leu Tyr          35 40 45 Gly Ala Leu Gln Pro Asn Glu Gly His Ile His Val Asp Gly Val Pro      50 55 60 Leu Ile Ser Leu His Arg Lys Asp Ile Ala Lys Thr Met Ala Val Val  65 70 75 80 Ile Gln Glu His Asp Ser Asp Leu Pro Met Thr Val Ala Asp Leu Val                  85 90 95 Leu Leu Gly Arg Leu Pro His Gln Lys Met Phe Ala Gly Asn Ser Gln             100 105 110 Ala Asp Gln Leu Leu Val Lys Glu Ala Leu Thr Arg Val Gly Ala Ile         115 120 125 His Leu Ala Asp Arg Gln Phe Gly Ala Leu Ser Gly Gly Glu Arg Gln     130 135 140 Arg Val Leu Ile Ala Arg Ala Leu Val Gln Asn Ala Thr His Ile Leu 145 150 155 160 Leu Asp Glu Pro Thr Asn His Leu Asp Ile Arg Tyr Gln His Glu Val                 165 170 175 Leu His Leu Val Arg Glu Leu Ser Ser Ser Ser Ile Val Leu His             180 185 190 Asp Leu Asn Leu Ala Gly Ala Tyr Ser Asp His Ile Ile Leu Leu Asp         195 200 205 Gln Gly Arg Val Val Thr Gln Gly Thr Pro Ser Glu Val Leu Thr Pro     210 215 220 Glu His Leu Glu Pro Val Tyr Gly Val Arg Val Glu Arg Phe Asp Leu 225 230 235 240 Gly Asp Glu Val His Leu Arg Phe Lys Arg His                 245 250 <210> 481 <211> 1161 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1138) <223> RXN02929 <400> 481 caggtgggga cctcgcgtat cccagctggt ggaagaaatc gcagcgcagt tgaatcagct 60 tgcttcttct gaagctgtgc cggccgctgc ttaagttttc gtg ctg aag aga att 115                                             Val Leu Lys Arg Ile                                               1 5 ttc ctc aac ccc tgg gtg gct acc gcg ttg tcg gta gtc att ttg ggg 163 Phe Leu Asn Pro Trp Val Ala Thr Ala Leu Ser Val Val Ile Leu Gly                  10 15 20 ttt gtg gtg ctg ttt tca ggt ttt agc ggt gtt att gat tta agc ccc 211 Phe Val Val Leu Phe Ser Gly Phe Ser Gly Val Ile Asp Leu Ser Pro              25 30 35 aca gca gtg att aga cat ttg agt ggg cag gac acg ctc acc cct cga 259 Thr Ala Val Ile Arg His Leu Ser Gly Gln Asp Thr Leu Thr Pro Arg          40 45 50 gat cag gcc atc ttc ttt gat atc cgg ctg cct cga att atc gct ggt 307 Asp Gln Ala Ile Phe Phe Asp Ile Arg Leu Pro Arg Ile Ile Ala Gly      55 60 65 gtc att gtc gga gca acg ctg gct att tct ggt gct tct tac caa gcg 355 Val Ile Val Gly Ala Thr Leu Ala Ile Ser Gly Ala Ser Tyr Gln Ala  70 75 80 85 gta ttt aga aac ccg ctg gct gat cct tat ttg ttg ggt gtg tcc gca 403 Val Phe Arg Asn Pro Leu Ala Asp Pro Tyr Leu Leu Gly Val Ser Ala                  90 95 100 ggt tct ggc ctt ggt gtc acg gca gtg att gtt ggc ggt acc gtg ctg 451 Gly Ser Gly Leu Gly Val Thr Ala Val Ile Val Gly Gly Thr Val Leu             105 110 115 gga ttt tct gca ccg agc atc ggc gtg att ggt gca gca ttt gta ggt 499 Gly Phe Ser Ala Pro Ser Ile Gly Val Ile Gly Ala Ala Phe Val Gly         120 125 130 ggt gtt gcc gca gta ctt gcc acg ctg atg gtg agt cgg gga gta gga 547 Gly Val Ala Ala Val Leu Ala Thr Leu Met Val Ser Arg Gly Val Gly     135 140 145 cag gga tca tca acc acc gtg gtt att ttg gcg ggc gtg gcg gtt gct 595 Gln Gly Ser Ser Thr Thr Val Val Ile Leu Ala Gly Val Ala Val Ala 150 155 160 165 gct ttt gcc agt tcc atc cag acc tat att cag caa cga cac atc gat 643 Ala Phe Ala Ser Ser Ile Gln Thr Tyr Ile Gln Gln Arg His Ile Asp                 170 175 180 acg gtg gcg cgc gta tat gtg tgg atg ttg ggc aac ctc aat gtc acc 691 Thr Val Ala Arg Val Tyr Val Trp Met Leu Gly Asn Leu Asn Val Thr             185 190 195 aac tgg atg tcg atc ttc atc gtg gct gtg gtg gcg gga cta tgc gcg 739 Asn Trp Met Ser Ile Phe Ile Val Ala Val Val Ala Gly Leu Cys Ala         200 205 210 gcc gtg atc atg tcc tgc gcc agg ttg tta gac gtg atg gct gtt ggt 787 Ala Val Ile Met Ser Cys Ala Arg Leu Leu Asp Val Met Ala Val Gly     215 220 225 gat gtg gaa gcc cgc aca ttg ggc gtc gat cca ggc ctc gta cgc att 835 Asp Val Glu Ala Arg Thr Leu Gly Val Asp Pro Gly Leu Val Arg Ile 230 235 240 245 ggc att gtc atc gtg gca acc ctt ggt aca gct gca gtg gta tcc att 883 Gly Ile Val Ile Val Ala Thr Leu Gly Thr Ala Ala Val Val Ser Ile                 250 255 260 tcc ggt ctc atc ggg ttt gtg ggc atc att gtt ccg cac gcc ctg cgc 931 Ser Gly Leu Ile Gly Phe Val Gly Ile Ile Val Pro His Ala Leu Arg             265 270 275 cta att gtt ggc ccg ggg cat cgg att tta ctg cca ctg tct ttc gta 979 Leu Ile Val Gly Pro Gly His Arg Ile Leu Leu Pro Leu Ser Phe Val         280 285 290 tgg ggt gcc att ttc ctc gtg ttg gca gat acc gca ggg cga aca ttg 1027 Trp Gly Ala Ile Phe Leu Val Leu Ala Asp Thr Ala Gly Arg Thr Leu     295 300 305 atg gct cct cag gaa ctt ccc gtg ggt gtg gtg aca gct gca ctc ggc 1075 Met Ala Pro Gln Glu Leu Pro Val Gly Val Val Thr Ala Ala Leu Gly 310 315 320 325 gca ccg ttc ttc tta ttt att ttg cgc aga acc agc aga caa cga gtt 1123 Ala Pro Phe Phe Leu Phe Ile Leu Arg Arg Thr Ser Arg Gln Arg Val                 330 335 340 cca aaa agg agt gct taagtggcga tcattgaatg cga 1161 Pro Lys Arg Ser Ala             345 <210> 482 <211> 346 <212> PRT <213> Corynebacterium glutamicum <400> 482 Val Leu Lys Arg Ile Phe Leu Asn Pro Trp Val Ala Thr Ala Leu Ser   1 5 10 15 Val Val Ile Leu Gly Phe Val Val Leu Phe Ser Gly Phe Ser Gly Val              20 25 30 Ile Asp Leu Ser Pro Thr Ala Val Ile Arg His Leu Ser Gly Gln Asp          35 40 45 Thr Leu Thr Pro Arg Asp Gln Ala Ile Phe Phe Asp Ile Arg Leu Pro      50 55 60 Arg Ile Ile Ala Gly Val Ile Val Gly Ala Thr Leu Ala Ile Ser Gly  65 70 75 80 Ala Ser Tyr Gln Ala Val Phe Arg Asn Pro Leu Ala Asp Pro Tyr Leu                  85 90 95 Leu Gly Val Ser Ala Gly Ser Gly Leu Gly Val Thr Ala Val Ile Val             100 105 110 Gly Gly Thr Val Leu Gly Phe Ser Ala Pro Ser Ile Gly Val Ile Gly         115 120 125 Ala Ala Phe Val Gly Gly Val Ala Ala Val Leu Ala Thr Leu Met Val     130 135 140 Ser Arg Gly Val Gly Gln Gly Ser Ser Thr Thr Val Val Ile Leu Ala 145 150 155 160 Gly Val Ala Val Ala Ala Phe Ala Ser Ser Ile Gln Thr Tyr Ile Gln                 165 170 175 Gln Arg His Ile Asp Thr Val Ala Arg Val Tyr Val Trp Met Leu Gly             180 185 190 Asn Leu Asn Val Thr Asn Trp Met Ser Ile Phe Ile Val Ala Val Val         195 200 205 Ala Gly Leu Cys Ala Ala Val Ile Met Ser Cys Ala Arg Leu Leu Asp     210 215 220 Val Met Ala Val Gly Asp Val Glu Ala Arg Thr Leu Gly Val Asp Pro 225 230 235 240 Gly Leu Val Arg Ile Gly Ile Val Ile Val Ala Thr Leu Gly Thr Ala                 245 250 255 Ala Val Val Ser Ile Ser Gly Leu Ile Gly Phe Val Gly Ile Ile Val             260 265 270 Pro His Ala Leu Arg Leu Ile Val Gly Pro Gly His Arg Ile Leu Leu         275 280 285 Pro Leu Ser Phe Val Trp Gly Ala Ile Phe Leu Val Leu Ala Asp Thr     290 295 300 Ala Gly Arg Thr Leu Met Ala Pro Gln Glu Leu Pro Val Gly Val Val 305 310 315 320 Thr Ala Ala Leu Gly Ala Pro Phe Phe Leu Phe Ile Leu Arg Arg Thr                 325 330 335 Ser Arg Gln Arg Val Pro Lys Arg Ser Ala             340 345 <210> 483 <211> 1095 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (1072) <223> FRXA01235 <400> 483 ttctgaagct gtgccggccg ctgcttaagt tttcgtgctg aagagaattt tcctcaaccc 60 ctgggtggct accgcgttgt cggtagtcat tttggggttt gtg gtg ctg ttt tca 115                                             Val Val Leu Phe Ser                                               1 5 ggt ttt agc ggt gtt att gat tta agc ccc aca gca gtg att aga cat 163 Gly Phe Ser Gly Val Ile Asp Leu Ser Pro Thr Ala Val Ile Arg His                  10 15 20 ttg agt ggg cag gac acg ctc acc cct cga gat cag gcc atc ttc ttt 211 Leu Ser Gly Gln Asp Thr Leu Thr Pro Arg Asp Gln Ala Ile Phe Phe              25 30 35 gat atc cgg ctg cct cga att atc gct ggt gtc att gtc gga gca acg 259 Asp Ile Arg Leu Pro Arg Ile Ile Ala Gly Val Ile Val Gly Ala Thr          40 45 50 ctg gct att tct ggt gct gct tac caa gcg gta ttt aga aac ccg ctg 307 Leu Ala Ile Ser Gly Ala Ala Tyr Gln Ala Val Phe Arg Asn Pro Leu      55 60 65 gct gat cct tat ttg ttg ggt gtg tcc gca ggt tct ggc ctt ggt gtc 355 Ala Asp Pro Tyr Leu Leu Gly Val Ser Ala Gly Ser Gly Leu Gly Val  70 75 80 85 acg gca gtg att gtt ggc ggt acc gtg ctg gga ttt tct gca ccg agc 403 Thr Ala Val Ile Val Gly Gly Thr Val Leu Gly Phe Ser Ala Pro Ser                  90 95 100 atc ggc gtg att ggt gca gca ttt gta ggt ggt gtt gcc gca gta ctt 451 Ile Gly Val Ile Gly Ala Ala Phe Val Gly Gly Val Ala Ala Val Leu             105 110 115 gcc acg ctg atg gtg agt cgg gga gta gga cag gga tca tca acc acc 499 Ala Thr Leu Met Val Ser Arg Gly Val Gly Gln Gly Ser Ser Thr Thr         120 125 130 gtg gtt att ttg gcg ggc gtg gcg gtt gct gct ttt gcc agt tcc atc 547 Val Val Ile Leu Ala Gly Val Ala Val Ala Ala Phe Ala Ser Ser Ile     135 140 145 cag acc tat att cag caa cga cac atc gat acg gtg gcg cgc gta tat 595 Gln Thr Tyr Ile Gln Gln Arg His Ile Asp Thr Val Ala Arg Val Tyr 150 155 160 165 gtg tgg atg ttg ggc aac ctc aat gtc acc aac tgg atg tcg atc ttc 643 Val Trp Met Leu Gly Asn Leu Asn Val Thr Asn Trp Met Ser Ile Phe                 170 175 180 atc gtg gct gtg gtg gcg gga cta tgc gcg gcc gtg atc atg tcc tgc 691 Ile Val Ala Val Val Ala Gly Leu Cys Ala Ala Val Ile Met Ser Cys             185 190 195 gcc agg ttg tta gac gtg atg gct gtt ggt gat gtg gaa gcc cgc aca 739 Ala Arg Leu Leu Asp Val Met Ala Val Gly Asp Val Glu Ala Arg Thr         200 205 210 ttg ggc gtc gat cca ggc ctc gta cgc att ggc att gtc atc gtg gca 787 Leu Gly Val Asp Pro Gly Leu Val Arg Ile Gly Ile Val Ile Val Ala     215 220 225 acc ctt ggt aca gct gca gtg gta tcc att tcc ggt ctc atc ggg ttt 835 Thr Leu Gly Thr Ala Ala Val Val Ser Ile Ser Gly Leu Ile Gly Phe 230 235 240 245 gtg ggc atc att gtt ccg cac gcc ctg cgc cta att gtt ggc ccg ggg 883 Val Gly Ile Ile Val Pro His Ala Leu Arg Leu Ile Val Gly Pro Gly                 250 255 260 cat cgg att tta ctg cca ctg tct ttc gta tgg ggt gcc att ttc ctc 931 His Arg Ile Leu Leu Pro Leu Ser Phe Val Trp Gly Ala Ile Phe Leu             265 270 275 gtg ttg gca gat acc gca ggg cga aca ttg atg gct cct cag gaa ctt 979 Val Leu Ala Asp Thr Ala Gly Arg Thr Leu Met Ala Pro Gln Glu Leu         280 285 290 ccc gtg ggt gtg gtg aca gct gca ctc ggc gca ccg ttc ttc tta ttt 1027 Pro Val Gly Val Val Thr Ala Ala Leu Gly Ala Pro Phe Phe Leu Phe     295 300 305 att ttg cgc aga acc agc aga caa cga gtt cca aaa agg agt gct 1072 Ile Leu Arg Arg Thr Ser Arg Gln Arg Val Pro Lys Arg Ser Ala 310 315 320 taagtggcga tcattgaatg cga 1095 <210> 484 <211> 324 <212> PRT <213> Corynebacterium glutamicum <400> 484 Val Val Leu Phe Ser Gly Phe Ser Gly Val Ile Asp Leu Ser Pro Thr   1 5 10 15 Ala Val Ile Arg His Leu Ser Gly Gln Asp Thr Leu Thr Pro Arg Asp              20 25 30 Gln Ala Ile Phe Phe Asp Ile Arg Leu Pro Arg Ile Ila Ala Gly Val          35 40 45 Ile Val Gly Ala Thr Leu Ala Ile Ser Gly Ala Ala Tyr Gln Ala Val      50 55 60 Phe Arg Asn Pro Leu Ala Asp Pro Tyr Leu Leu Gly Val Ser Ala Gly  65 70 75 80 Ser Gly Leu Gly Val Thr Ala Val Ile Val Gly Gly Thr Val Leu Gly                  85 90 95 Phe Ser Ala Pro Ser Ile Gly Val Ile Gly Ala Ala Phe Val Gly Gly             100 105 110 Val Ala Ala Val Leu Ala Thr Leu Met Val Ser Arg Gly Val Gly Gln         115 120 125 Gly Ser Ser Thr Thr Val Val Ile Leu Ala Gly Val Ala Val Ala Ala     130 135 140 Phe Ala Ser Ser Ile Gln Thr Tyr Ile Gln Gln Arg His Ile Asp Thr 145 150 155 160 Val Ala Arg Val Tyr Val Trp Met Leu Gly Asn Leu Asn Val Thr Asn                 165 170 175 Trp Met Ser Ile Phe Ile Val Ala Val Val Ala Gly Leu Cys Ala Ala             180 185 190 Val Ile Met Ser Cys Ala Arg Leu Leu Asp Val Met Ala Val Gly Asp         195 200 205 Val Glu Ala Arg Thr Leu Gly Val Asp Pro Gly Leu Val Arg Ile Gly     210 215 220 Ile Val Ile Val Ala Thr Leu Gly Thr Ala Ala Val Val Ser Ile Ser 225 230 235 240 Gly Leu Ile Gly Phe Val Gly Ile Ile Val Pro His Ala Leu Arg Leu                 245 250 255 Ile Val Gly Pro Gly His Arg Ile Leu Leu Pro Leu Ser Phe Val Trp             260 265 270 Gly Ala Ile Phe Leu Val Leu Ala Asp Thr Ala Gly Arg Thr Leu Met         275 280 285 Ala Pro Gln Glu Leu Pro Val Gly Val Val Thr Ala Ala Leu Gly Ala     290 295 300 Pro Phe Phe Leu Phe Ile Leu Arg Arg Thr Ser Arg Gln Arg Val Pro 305 310 315 320 Lys Arg Ser Ala <210> 485 <211> 1197 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) .. (1174) <223> RXN02794 <400> 485 gcgcccactc atcggcgagc ttcaggagat gaggttgatg ctccattgat aatttctttc 60 gctaatagtc aaatgatcat ttgagtgtta gtgttttctc atg ctt ctt tcc gcc 115                                             Met Leu Leu Ser Ala                                               1 5 cgc aca cac acg agt ttc caa gaa ctt gga ctc aat gct agt cgg cgc 163 Arg Thr His Thr Ser Phe Gln Glu Leu Gly Leu Asn Ala Ser Arg Arg                  10 15 20 aaa gca atc aac tgg aca ctg gca ctc act gtg gtg cta att gcc tcc 211 Lys Ala Ile Asn Trp Thr Leu Ala Leu Thr Val Val Leu Ile Ala Ser              25 30 35 atg ttt gtt ggc gtg ctc atc ggt gca tcc ggg acc tca gtg ttt tcc 259 Met Phe Val Gly Val Leu Ile Gly Ala Ser Gly Thr Ser Val Phe Ser          40 45 50 acg tgg acc gta att agc cac cat ctt ttt ggc act gag cta ggt ggc 307 Thr Trp Thr Val Ile Ser His His Leu Phe Gly Thr Glu Leu Gly Gly      55 60 65 tcc gac act gcc gac gcc atc att tgg tac atc cgc acc cca cgc gtc 355 Ser Asp Thr Ala Asp Ala Ile Ile Trp Tyr Ile Arg Thr Pro Arg Val  70 75 80 85 ttg ctc gct gcc att gtg ggc gca ggc ctt gcc ctg gca ggt gcc atc 403 Leu Leu Ala Ala Ile Val Gly Ala Gly Leu Ala Leu Ala Gly Ala Ile                  90 95 100 atg caa gta ctg gtc cga aac atg ctg gca gac ccc tat atc ctc ggg 451 Met Gln Val Leu Val Arg Asn Met Leu Ala Asp Pro Tyr Ile Leu Gly             105 110 115 gtg aac tca ggt gcc agt tgc ggt gcg gcc gct gcc tta ctg ttc gga 499 Val Asn Ser Gly Ala Ser Cys Gly Ala Ala Ala Ala Leu Leu Phe Gly         120 125 130 gtg ggc gct gga ttt ggc gat tac gcc ctc caa ggc agc gcg ttt ctc 547 Val Gly Ala Gly Phe Gly Asp Tyr Ala Leu Gln Gly Ser Ala Phe Leu     135 140 145 ggc gca atg gca gct tcc gga ttg atc ttc ttc gtg gcg cgc gca gcg 595 Gly Ala Met Ala Ala Ser Gly Leu Ile Phe Phe Val Ala Arg Ala Ala 150 155 160 165 ggg cgc atc tcc tcg acc cgc ttg ttg atg tcc ggc gta gcg atc gga 643 Gly Arg Ile Ser Ser Thr Arg Leu Leu Met Ser Gly Val Ala Ile Gly                 170 175 180 tac atg ctc tct gcg gca aca agc ttt ctc atc ttc tcc tcc gac tcc 691 Tyr Met Leu Ser Ala Ala Thr Ser Phe Leu Ile Phe Ser Ser Asp Ser             185 190 195 gcc gaa ggc agc cgc tcc gtg ttg ttc tgg ctg ctt gga tcc tta gga 739 Ala Glu Gly Ser Arg Ser Val Leu Phe Trp Leu Leu Gly Ser Leu Gly         200 205 210 ctt gcc gca tgg aat ggg ccg atg gcg atc atc ttc ctc atc gtg ggc 787 Leu Ala Ala Trp Asn Gly Pro Met Ala Ile Ile Phe Leu Ile Val Gly     215 220 225 att gcc ctg gcg ttg ctc atg gtg ttg ggt ccg caa ttg gat gcc tta 835 Ile Ala Leu Ala Leu Leu Met Val Leu Gly Pro Gln Leu Asp Ala Leu 230 235 240 245 aac tcc ggc gat gaa acc gca ctt acc ttg gga gta tcc cct gat cgc 883 Asn Ser Gly Asp Glu Thr Ala Leu Thr Leu Gly Val Ser Pro Asp Arg                 250 255 260 ctc cgc att ctc ctc ctg gtg atc acc tgc ctg ctg gtg gga tcc atg 931 Leu Arg Ile Leu Leu Leu Val Ile Thr Cys Leu Leu Val Gly Ser Met             265 270 275 gtt gcc atg gcc ggc agc atc gga ttc atc ggc ctt gtc atc ccc cac 979 Val Ala Met Ala Gly Ser Ile Gly Phe Ile Gly Leu Val Ile Pro His         280 285 290 ctg gcc agg cgt ttt gtt agt gga aaa cac cga ctc atg ctg cct gta 1027 Leu Ala Arg Arg Phe Val Ser Gly Lys His Arg Leu Met Leu Pro Val     295 300 305 tcc gcg ttg atg ggc gca att ttg ctc atc tgg gct gat atc gcc gcc 1075 Ser Ala Leu Met Gly Ala Ile Leu Leu Ile Trp Ala Asp Ile Ala Ala 310 315 320 325 cgc acc ctg ctt gcg ccc caa gag att ccc atc ggc atc atc acc gca 1123 Arg Thr Leu Leu Ala Pro Gln Glu Ile Pro Ile Gly Ile Ile Thr Ala                 330 335 340 ctc atc gga gca ccc ttc ctc ctg att ctg gtt cgc cgg atg cac acc 1171 Leu Ile Gly Ala Pro Phe Leu Leu Ile Leu Val Arg Arg Met His Thr             345 350 355 tac tgatttttaa ggaattatgc gta 1197 Tyr <210> 486 <211> 358 <212> PRT <213> Corynebacterium glutamicum <400> 486 Met Leu Leu Ser Ala Arg Thr His Thr Ser Phe Gln Glu Leu Gly Leu   1 5 10 15 Asn Ala Ser Arg Arg Lys Ala Ile Asn Trp Thr Leu Ala Leu Thr Val              20 25 30 Val Leu Ile Ala Ser Met Phe Val Gly Val Leu Ile Gly Ala Ser Gly          35 40 45 Thr Ser Val Phe Ser Thr Trp Thr Val Ile Ser His His Leu Phe Gly      50 55 60 Thr Glu Leu Gly Gly Ser Asp Thr Ala Asp Ala Ile Irp Trp Tyr Ile  65 70 75 80 Arg Thr Pro Arg Val Leu Leu Ala Ala Ile Val Gly Ala Gly Leu Ala                  85 90 95 Leu Ala Gly Ala Ile Met Gln Val Leu Val Arg Asn Met Leu Ala Asp             100 105 110 Pro Tyr Ile Leu Gly Val Asn Ser Gly Ala Ser Cys Gly Ala Ala Ala         115 120 125 Ala Leu Leu Phe Gly Val Gly Ala Gly Phe Gly Asp Tyr Ala Leu Gln     130 135 140 Gly Ser Ala Phe Leu Gly Ala Met Ala Ala Ser Gly Leu Ile Phe Phe 145 150 155 160 Val Ala Arg Ala Ala Gly Arg Ile Ser Ser Thr Arg Leu Leu Met Ser                 165 170 175 Gly Val Ala Ile Gly Tyr Met Leu Ser Ala Ala Thr Ser Phe Leu Ile             180 185 190 Phe Ser Ser Asp Ser Ala Glu Gly Ser Arg Ser Val Leu Phe Trp Leu         195 200 205 Leu Gly Ser Leu Gly Leu Ala Ala Trp Asn Gly Pro Met Ala Ile Ile     210 215 220 Phe Leu Ile Val Gly Ile Ala Leu Ala Leu Leu Met Val Leu Gly Pro 225 230 235 240 Gln Leu Asp Ala Leu Asn Ser Gly Asp Glu Thr Ala Leu Thr Leu Gly                 245 250 255 Val Ser Pro Asp Arg Leu Arg Ile Leu Leu Leu Val Ile Thr Cys Leu             260 265 270 Leu Val Gly Ser Met Val Ala Met Ala Gly Ser Ile Gly Phe Ile Gly         275 280 285 Leu Val Ile Pro His Leu Ala Arg Arg Phe Val Ser Gly Lys His Arg     290 295 300 Leu Met Leu Pro Val Ser Ala Leu Met Gly Ala Ile Leu Leu Ile Trp 305 310 315 320 Ala Asp Ile Ala Ala Arg Thr Leu Leu Ala Pro Gln Glu Ile Pro Ile                 325 330 335 Gly Ile Ile Thr Ala Leu Ile Gly Ala Pro Phe Leu Leu Ile Leu Val             340 345 350 Arg Arg Met His Thr Tyr         355 <210> 487 <211> 364 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (364) <223> FRXA01419 <400> 487 gcgcccactc atcggcgagc ttcaggagat gaggttgatg ctccattgat aatttctttc 60 gctaatagtc aaatgatcat ttgagtgtta gtgttttctc atg ctt ctt tcc gcc 115                                             Met Leu Leu Ser Ala                                               1 5 cgc aca cac acg agt ttc caa gaa ctt gga ctc aat gct agt cgg cgc 163 Arg Thr His Thr Ser Phe Gln Glu Leu Gly Leu Asn Ala Ser Arg Arg                  10 15 20 aaa gca atc aac tgg aca ctg gca ctc act gtg gtg cta att gcc tcc 211 Lys Ala Ile Asn Trp Thr Leu Ala Leu Thr Val Val Leu Ile Ala Ser              25 30 35 atg ttt gtt ggc gtg ctc atc ggt gca tcc ggg acc tca gtg ttt tcc 259 Met Phe Val Gly Val Leu Ile Gly Ala Ser Gly Thr Ser Val Phe Ser          40 45 50 acg tgg acc gta att agc cac cat ctt ttt ggc act gag cta ggt ggc 307 Thr Trp Thr Val Ile Ser His His Leu Phe Gly Thr Glu Leu Gly Gly      55 60 65 tcc gac act gcc gac gcc atc att tgg tac atc cgc acc cca cgc gtc 355 Ser Asp Thr Ala Asp Ala Ile Ile Trp Tyr Ile Arg Thr Pro Arg Val  70 75 80 85 ttg ctc gct 364 Leu Leu Ala <210> 488 <211> 88 <212> PRT <213> Corynebacterium glutamicum <400> 488 Met Leu Leu Ser Ala Arg Thr His Thr Ser Phe Gln Glu Leu Gly Leu   1 5 10 15 Asn Ala Ser Arg Arg Lys Ala Ile Asn Trp Thr Leu Ala Leu Thr Val              20 25 30 Val Leu Ile Ala Ser Met Phe Val Gly Val Leu Ile Gly Ala Ser Gly          35 40 45 Thr Ser Val Phe Ser Thr Trp Thr Val Ile Ser His His Leu Phe Gly      50 55 60 Thr Glu Leu Gly Gly Ser Asp Thr Ala Asp Ala Ile Irp Trp Tyr Ile  65 70 75 80 Arg Thr Pro Arg Val Leu Leu Ala                  85 <210> 489 <211> 744 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (721) <223> FRXA02794 <400> 489 tgaactcagg tgccagttgc ggtgcggccg ctgccttact gttcggagtg ggcgctggat 60 ttggcgatta cgccctccaa gcagcgcgtt tctcggcgca atg gca gct tcc gga 115                                             Met Ala Ala Ser Gly                                               1 5 ttg atc ttc ttc gtg gcg cgc gca gcg ggg cgc atc tcc tcg acc cgc 163 Leu Ile Phe Phe Val Ala Arg Ala Ala Gly Arg Ile Ser Ser Thr Arg                  10 15 20 ttg ttg atg tcc ggc gta gcg atc gga tac atg ctc tct gcg gca aca 211 Leu Leu Met Ser Gly Val Ala Ile Gly Tyr Met Leu Ser Ala Ala Thr              25 30 35 agc ttt ctc atc ttc tcc tcc gac tcc gcc gaa ggc agc cgc tcc gtg 259 Ser Phe Leu Ile Phe Ser Ser Asp Ser Ala Glu Gly Ser Arg Ser Val          40 45 50 ttg ttc tgg ctg ctt gga tcc tta gga ctt gcc gca tgg aat ggg ccg 307 Leu Phe Trp Leu Leu Gly Ser Leu Gly Leu Ala Ala Trp Asn Gly Pro      55 60 65 atg gcg atc atc ttc ctc atc gtg ggc att gcc ctg gcg ttg ctc atg 355 Met Ala Ile Ile Phe Leu Ile Val Gly Ile Ala Leu Ala Leu Leu Met  70 75 80 85 gtg ttg ggt ccg caa ttg gat gcc tta aac tcc ggc gat gaa acc gca 403 Val Leu Gly Pro Gln Leu Asp Ala Leu Asn Ser Gly Asp Glu Thr Ala                  90 95 100 ctt acc ttg gga gta tcc cct gat cgc ctc cgc att ctc ctc ctg gtg 451 Leu Thr Leu Gly Val Ser Pro Asp Arg Leu Arg Ile Leu Leu Leu Val             105 110 115 atc acc tgc ctg ctg gtg gga tcc atg gtt gcc atg gcc ggc agc atc 499 Ile Thr Cys Leu Leu Val Gly Ser Met Val Ala Met Ala Gly Ser Ile         120 125 130 gga ttc atc ggc ctt gtc atc ccc cac ctg gcc agg cgt ttt gtt agt 547 Gly Phe Ile Gly Leu Val Ile Pro His Leu Ala Arg Arg Phe Val Ser     135 140 145 gga aaa cac cga ctc atg ctg cct gta tcc gcg ttg atg ggc gca att 595 Gly Lys His Arg Leu Met Leu Pro Val Ser Ala Leu Met Gly Ala Ile 150 155 160 165 ttg ctc atc tgg gct gat atc gcc gcc cgc acc ctg ctt gcg ccc caa 643 Leu Leu Ile Trp Ala Asp Ile Ala Ala Arg Thr Leu Leu Ala Pro Gln                 170 175 180 gag att ccc atc ggc atc atc acc gca ctc atc gga gca ccc ttc ctc 691 Glu Ile Pro Ile Gly Ile Ile Thr Ala Leu Ile Gly Ala Pro Phe Leu             185 190 195 ctg att ctg gtt cgc cgg atg cac acc tac tgatttttaa ggaattatgc 741 Leu Ile Leu Val Arg Arg Met His Thr Tyr         200 205 gta 744 <210> 490 <211> 207 <212> PRT <213> Corynebacterium glutamicum <400> 490 Met Ala Ala Ser Gly Leu Ile Phe Phe Val Ala Arg Ala Ala Gly Arg   1 5 10 15 Ile Ser Ser Thr Arg Leu Leu Met Ser Gly Val Ala Ile Gly Tyr Met              20 25 30 Leu Ser Ala Ala Thr Ser Phe Leu Ile Phe Ser Ser Asp Ser Ala Glu          35 40 45 Gly Ser Arg Ser Val Leu Phe Trp Leu Leu Gly Ser Leu Gly Leu Ala      50 55 60 Ala Trp Asn Gly Pro Met Ala Ile Ile Phe Leu Ile Val Gly Ile Ala  65 70 75 80 Leu Ala Leu Leu Met Val Leu Gly Pro Gln Leu Asp Ala Leu Asn Ser                  85 90 95 Gly Asp Glu Thr Ala Leu Thr Leu Gly Val Ser Pro Asp Arg Leu Arg             100 105 110 Ile Leu Leu Leu Val Ile Thr Cys Leu Leu Val Gly Ser Met Val Ala         115 120 125 Met Ala Gly Ser Ile Gly Phe Ile Gly Leu Val Ile Pro His Leu Ala     130 135 140 Arg Arg Phe Val Ser Gly Lys His Arg Leu Met Leu Pro Val Ser Ala 145 150 155 160 Leu Met Gly Ala Ile Leu Leu Ile Trp Ala Asp Ile Ala Ala Arg Thr                 165 170 175 Leu Leu Ala Pro Gln Glu Ile Pro Ile Gly Ile Ile Thr Ala Leu Ile             180 185 190 Gly Ala Pro Phe Leu Leu Ile Leu Val Arg Arg Met His Thr Tyr         195 200 205 <210> 491 <211> 1140 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1117) <223> RXN03079 <400> 491 gagcggggtt gctatcggcc gaaagtttag ggttttgttc aatctgttgg ttagtattgc 60 ttgggtaaac aagtcataac aattttcatt aagggtcgtt ttg tcg cgc aca ggt 115                                             Leu Ser Arg Thr Gly                                               1 5 gtt tcg aaa aaa cca aag ctc acc gct cct gtt gtc atc atc ggc acc 163 Val Ser Lys Lys Pro Lys Leu Thr Ala Pro Val Val Ile Ily Gly Thr                  10 15 20 ctc gtc ttg ttg atc atc gcc ttc acc gct tcc ctc atg ctg ggt ccc 211 Leu Val Leu Leu Ile Ile Ala Phe Thr Ala Ser Leu Met Leu Gly Pro              25 30 35 gtg acg gtt cca ttg aat gag ctt gca acc aac ccc gtt gtc acc gat 259 Val Thr Val Pro Leu Asn Glu Leu Ala Thr Asn Pro Val Val Thr Asp          40 45 50 atc cgt gca cca cgc att atc atc gca gca ttg gtg ggt gcg gcg ctg 307 Ile Arg Ala Pro Arg Ile Ile Ile Ala Ala Leu Val Gly Ala Ala Leu      55 60 65 gct gtc tcc ggt gcg atc atg cag acg gtg ttt cac aac ccg ttg gcg 355 Ala Val Ser Gly Ala Ile Met Gln Thr Val Phe His Asn Pro Leu Ala  70 75 80 85 gat ccc ggc att gtg ggt gtg tcc tcc ggt gca gct gtt gca gct gtc 403 Asp Pro Gly Ile Val Gly Val Ser Ser Gly Ala Ala Val Ala Ala Val                  90 95 100 ttg gcg att gtc acc ggt gcg agt ttc ttt ggc caa tgg acc gtt cct 451 Leu Ala Ile Val Thr Gly Ala Ser Phe Phe Gly Gln Trp Thr Val Pro             105 110 115 ttt gcg gcc ttc gtg ggc gca ttg gtc acg gtg gct gtg gta tat ttg 499 Phe Ala Ala Phe Val Gly Ala Leu Val Thr Val Ala Val Val Tyr Leu         120 125 130 atc gct agt tcc cgc gcg atg gat ggc cgt ggc gca gat ccg gcc acg 547 Ile Ala Ser Ser Arg Ala Met Asp Gly Arg Gly Ala Asp Pro Ala Thr     135 140 145 ttg gta ctg gtc ggc atg gct atc act gcc ttt ttg ggt gct gtt att 595 Leu Val Leu Val Gly Met Ala Ile Thr Ala Phe Leu Gly Ala Val Ile 150 155 160 165 tcc agc gcc act gcg aac gca cca caa gat tct gag ctt cga tcc gtg 643 Ser Ser Ala Thr Ala Asn Ala Pro Gln Asp Ser Glu Leu Arg Ser Val                 170 175 180 acg ttt tgg ctc aac ggc gat ctg gta tct cgg acg tgg gaa cat gtg 691 Thr Phe Trp Leu Asn Gly Asp Leu Val Ser Arg Thr Trp Glu His Val             185 190 195 ggc gtt gca ata atc ccc att atc gtt ggg ttg att cta gct atc ggc 739 Gly Val Ala Ile Ile Pro Ile Ile Val Gly Leu Ile Leu Ala Ile Gly         200 205 210 ggt tcc cgc gat ctg aac ttg ttg ctg ctg ggt gat tcc aca gcg caa 787 Gly Ser Arg Asp Leu Asn Leu Leu Leu Leu Gly Asp Ser Thr Ala Gln     215 220 225 aca tct gga ctc aac gtc aac cgc gca cgc atc att ttg cta gca ctt 835 Thr Ser Gly Leu Asn Val Asn Arg Ala Arg Ile Ile Leu Leu Ala Leu 230 235 240 245 gcg gca ctg ctc acc gcc aca gct gtt gcg gtc tcc ggc acc att acg 883 Ala Ala Leu Leu Thr Ala Thr Ala Val Ala Val Ser Gly Thr Ile Thr                 250 255 260 ttt gtt gga ttg gta gta ccc cac ctg gtg cgc att gtt tta ggt gcc 931 Phe Val Gly Leu Val Val Pro His Leu Val Arg Ile Val Leu Gly Ala             265 270 275 gat cac cga gcg tta ctc ccg gcc gcc gcg att ttg ggc gcc acg ttt 979 Asp His Arg Ala Leu Leu Pro Ala Ala Ala Ile Leu Gly Ala Thr Phe         280 285 290 gtt atc gtt tcc gac act gtt gcc cgc atg atc ttc tcc ccc atc gtc 1027 Val Ile Val Ser Asp Thr Val Ala Arg Met Ile Phe Ser Pro Ile Val     295 300 305 ttg caa aca ggc gtg gtg gtg gcg ttc att ggc tca cca att ttc ctt 1075 Leu Gln Thr Gly Val Val Val Ala Phe Ile Gly Ser Pro Ile Phe Leu 310 315 320 325 tat tta ctg ctc agc atg cgc aag cga cgc gga ttg ggg ctg 1117 Tyr Leu Leu Leu Ser Met Arg Lys Arg Arg Gly Leu Gly Leu                 330 335 taaaaactca tgcctcaatt agt 1140 <210> 492 <211> 339 <212> PRT <213> Corynebacterium glutamicum <400> 492 Leu Ser Arg Thr Gly Val Ser Lys Lys Pro Lys Leu Thr Ala Pro Val   1 5 10 15 Val Ile Ile Gly Thr Leu Val Leu Leu Ile Ile Ala Phe Thr Ala Ser              20 25 30 Leu Met Leu Gly Pro Val Thr Val Pro Leu Asn Glu Leu Ala Thr Asn          35 40 45 Pro Val Val Thr Asp Ile Arg Ala Pro Arg Ile Ile Ile Ala Ala Leu      50 55 60 Val Gly Ala Ala Leu Ala Val Ser Gly Ala Ile Met Gln Thr Val Phe  65 70 75 80 His Asn Pro Leu Ala Asp Pro Gly Ile Val Gly Val Ser Ser Gly Ala                  85 90 95 Ala Val Ala Ala Val Leu Ala Ile Val Thr Gly Ala Ser Phe Phe Gly             100 105 110 Gln Trp Thr Val Pro Phe Ala Ala Phe Val Gly Ala Leu Val Thr Val         115 120 125 Ala Val Val Tyr Leu Ile Ala Ser Ser Arg Ala Met Asp Gly Arg Gly     130 135 140 Ala Asp Pro Ala Thr Leu Val Leu Val Gly Met Ala Ile Thr Ala Phe 145 150 155 160 Leu Gly Ala Val Ile Ser Ser Ala Thr Ala Asn Ala Pro Gln Asp Ser                 165 170 175 Glu Leu Arg Ser Val Thr Phe Trp Leu Asn Gly Asp Leu Val Ser Arg             180 185 190 Thr Trp Glu His Val Gly Val Ala Ile Ile Pro Ile Ile Val Gly Leu         195 200 205 Ile Leu Ala Ile Gly Gly Ser Arg Asp Leu Asn Leu Leu Leu Leu Gly     210 215 220 Asp Ser Thr Ala Gln Thr Ser Gly Leu Asn Val Asn Arg Ala Arg Ile 225 230 235 240 Ile Leu Leu Ala Leu Ala Ala Leu Leu Thr Ala Thr Ala Val Ala Val                 245 250 255 Ser Gly Thr Ile Thr Phe Val Gly Leu Val Val Pro His Leu Val Arg             260 265 270 Ile Val Leu Gly Ala Asp His Arg Ala Leu Leu Pro Ala Ala Ala Ile         275 280 285 Leu Gly Ala Thr Phe Val Ile Val Ser Asp Thr Val Ala Arg Met Ile     290 295 300 Phe Ser Pro Ile Val Leu Gln Thr Gly Val Val Val Ala Phe Ile Gly 305 310 315 320 Ser Pro Ile Phe Leu Tyr Leu Leu Leu Ser Met Arg Lys Arg Arg Gly                 325 330 335 Leu Gly Leu <210> 493 <211> 1140 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1117) <223> FRXA02865 <400> 493 gagcggggtt gctatcggcc gaaagtttag ggttttgttc aatctgttgg ttagtattgc 60 ttgggtaaac aagtcataac aattttcatt aagggtcgtt ttg tcg cgc aca ggt 115                                             Leu Ser Arg Thr Gly                                               1 5 gtt tcg aaa aaa cca aag ctc acc gct cct gtt gtc atc atc ggc acc 163 Val Ser Lys Lys Pro Lys Leu Thr Ala Pro Val Val Ile Ily Gly Thr                  10 15 20 ctc gtc ttg ttg atc atc gcc ttc acc gct tcc ctc atg ctg ggt ccc 211 Leu Val Leu Leu Ile Ile Ala Phe Thr Ala Ser Leu Met Leu Gly Pro              25 30 35 gtg acg gtt cca ttg aat gag ctt gca acc aac ccc gtt gtc acc gat 259 Val Thr Val Pro Leu Asn Glu Leu Ala Thr Asn Pro Val Val Thr Asp          40 45 50 atc cgt gca cca cgc att atc atc gca gca ttg gtg ggt gcg gcg ctg 307 Ile Arg Ala Pro Arg Ile Ile Ile Ala Ala Leu Val Gly Ala Ala Leu      55 60 65 gct gtc tcc ggt gcg atc atg cag acg gtg ttt cac aac ccg ttg gcg 355 Ala Val Ser Gly Ala Ile Met Gln Thr Val Phe His Asn Pro Leu Ala  70 75 80 85 gat ccc ggc att gtg ggt gtg tcc tcc ggt gca gct gtt gca gct gtc 403 Asp Pro Gly Ile Val Gly Val Ser Ser Gly Ala Ala Val Ala Ala Val                  90 95 100 ttg gcg att gtc acc ggt gcg agt ttc ttt ggc caa tgg acc gtt cct 451 Leu Ala Ile Val Thr Gly Ala Ser Phe Phe Gly Gln Trp Thr Val Pro             105 110 115 ttt gcg gcc ttc gtg ggc gca ttg gtc acg gtg gct gtg gta tat ttg 499 Phe Ala Ala Phe Val Gly Ala Leu Val Thr Val Ala Val Val Tyr Leu         120 125 130 atc gct agt tcc cgc gcg atg gat ggc cgt ggc gca gat ccg gcc acg 547 Ile Ala Ser Ser Arg Ala Met Asp Gly Arg Gly Ala Asp Pro Ala Thr     135 140 145 ttg gta ctg gtc ggc atg gct atc act gcc ttt ttg ggt gct gtt att 595 Leu Val Leu Val Gly Met Ala Ile Thr Ala Phe Leu Gly Ala Val Ile 150 155 160 165 tcc agc gcc act gcg aac gca cca caa gat tct gag ctt cga tcc gtg 643 Ser Ser Ala Thr Ala Asn Ala Pro Gln Asp Ser Glu Leu Arg Ser Val                 170 175 180 acg ttt tgg ctc aac ggc gat ctg gta tct cgg acg tgg gaa cat gtg 691 Thr Phe Trp Leu Asn Gly Asp Leu Val Ser Arg Thr Trp Glu His Val             185 190 195 ggc gtt gca ata atc ccc att atc gtt ggg ttg att cta gct atc ggc 739 Gly Val Ala Ile Ile Pro Ile Ile Val Gly Leu Ile Leu Ala Ile Gly         200 205 210 ggt tcc cgc gat ctg aac ttg ttg ctg ctg ggt gat tcc aca gcg caa 787 Gly Ser Arg Asp Leu Asn Leu Leu Leu Leu Gly Asp Ser Thr Ala Gln     215 220 225 aca tct gga ctc aac gtc aac cgc gca cgc atc att ttg cta gca ctt 835 Thr Ser Gly Leu Asn Val Asn Arg Ala Arg Ile Ile Leu Leu Ala Leu 230 235 240 245 gcg gca ctg ctc acc gcc aca gct gtt gcg gtc tcc ggc acc att acg 883 Ala Ala Leu Leu Thr Ala Thr Ala Val Ala Val Ser Gly Thr Ile Thr                 250 255 260 ttt gtt gga ttg gta gta ccc cac ctg gtg cgc att gtt tta ggt gcc 931 Phe Val Gly Leu Val Val Pro His Leu Val Arg Ile Val Leu Gly Ala             265 270 275 gat cac cga gcg tta ctc ccg gcc gcc gcg att ttg ggc gcc acg ttt 979 Asp His Arg Ala Leu Leu Pro Ala Ala Ala Ile Leu Gly Ala Thr Phe         280 285 290 gtt atc gtt tcc gac act gtt gcc cgc atg atc ttc tcc ccc atc gtc 1027 Val Ile Val Ser Asp Thr Val Ala Arg Met Ile Phe Ser Pro Ile Val     295 300 305 ttg caa aca ggc gtg gtg gtg gcg ttc att ggc tca cca att ttc ctt 1075 Leu Gln Thr Gly Val Val Val Ala Phe Ile Gly Ser Pro Ile Phe Leu 310 315 320 325 tat tta ctg ctc agc atg cgc aag cga cgc gga ttg ggg ctg 1117 Tyr Leu Leu Leu Ser Met Arg Lys Arg Arg Gly Leu Gly Leu                 330 335 taaaaactca tgcctcaatt agt 1140 <210> 494 <211> 339 <212> PRT <213> Corynebacterium glutamicum <400> 494 Leu Ser Arg Thr Gly Val Ser Lys Lys Pro Lys Leu Thr Ala Pro Val   1 5 10 15 Val Ile Ile Gly Thr Leu Val Leu Leu Ile Ile Ala Phe Thr Ala Ser              20 25 30 Leu Met Leu Gly Pro Val Thr Val Pro Leu Asn Glu Leu Ala Thr Asn          35 40 45 Pro Val Val Thr Asp Ile Arg Ala Pro Arg Ile Ile Ile Ala Ala Leu      50 55 60 Val Gly Ala Ala Leu Ala Val Ser Gly Ala Ile Met Gln Thr Val Phe  65 70 75 80 His Asn Pro Leu Ala Asp Pro Gly Ile Val Gly Val Ser Ser Gly Ala                  85 90 95 Ala Val Ala Ala Val Leu Ala Ile Val Thr Gly Ala Ser Phe Phe Gly             100 105 110 Gln Trp Thr Val Pro Phe Ala Ala Phe Val Gly Ala Leu Val Thr Val         115 120 125 Ala Val Val Tyr Leu Ile Ala Ser Ser Arg Ala Met Asp Gly Arg Gly     130 135 140 Ala Asp Pro Ala Thr Leu Val Leu Val Gly Met Ala Ile Thr Ala Phe 145 150 155 160 Leu Gly Ala Val Ile Ser Ser Ala Thr Ala Asn Ala Pro Gln Asp Ser                 165 170 175 Glu Leu Arg Ser Val Thr Phe Trp Leu Asn Gly Asp Leu Val Ser Arg             180 185 190 Thr Trp Glu His Val Gly Val Ala Ile Ile Pro Ile Ile Val Gly Leu         195 200 205 Ile Leu Ala Ile Gly Gly Ser Arg Asp Leu Asn Leu Leu Leu Leu Gly     210 215 220 Asp Ser Thr Ala Gln Thr Ser Gly Leu Asn Val Asn Arg Ala Arg Ile 225 230 235 240 Ile Leu Leu Ala Leu Ala Ala Leu Leu Thr Ala Thr Ala Val Ala Val                 245 250 255 Ser Gly Thr Ile Thr Phe Val Gly Leu Val Val Pro His Leu Val Arg             260 265 270 Ile Val Leu Gly Ala Asp His Arg Ala Leu Leu Pro Ala Ala Ala Ile         275 280 285 Leu Gly Ala Thr Phe Val Ile Val Ser Asp Thr Val Ala Arg Met Ile     290 295 300 Phe Ser Pro Ile Val Leu Gln Thr Gly Val Val Val Ala Phe Ile Gly 305 310 315 320 Ser Pro Ile Phe Leu Tyr Leu Leu Leu Ser Met Arg Lys Arg Arg Gly                 325 330 335 Leu Gly Leu <210> 495 <211> 1695 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (1672) <223> RXA00181 <400> 495 gtatattcag acacccacgt cgattagtgt tgtagttcac agtgcttatt ttttatttgt 60 atctttgcac gtttgtcccc tacccaaaag gagaaacctc atg agc gat aac acc 115                                             Met Ser Asp Asn Thr                                               1 5 tgg ttc atc ata gcc atc gtt atc tat atg ttg gtg atg gtg ctc atc 163 Trp Phe Ile Ile Ala Ile Val Ile Tyr Met Leu Val Met Val Leu Ile                  10 15 20 ggc tat tgg agt tac cgc aag aca gaa aaa tac gac gac tac atg ctc 211 Gly Tyr Trp Ser Tyr Arg Lys Thr Glu Lys Tyr Asp Asp Tyr Met Leu              25 30 35 gcc ggc cgc ggg ctc aac cct ttt gtt gcc gca atg tcc gca ggt gcc 259 Ala Gly Arg Gly Leu Asn Pro Phe Val Ala Ala Met Ser Ala Gly Ala          40 45 50 tca gat atg tca ggt tgg ctg ctc atg ggt ctg ccc ggc gcg ctg ttt 307 Ser Asp Met Ser Gly Trp Leu Leu Met Gly Leu Pro Gly Ala Leu Phe      55 60 65 gtc acc ggc atg tcc gag ttg tgg atc gca gtc gga ctc acc att ggt 355 Val Thr Gly Met Ser Glu Leu Trp Ile Ala Val Gly Leu Thr Ile Gly  70 75 80 85 gca tgg gcg aac tgg atg tgg gtg gca cct cgt ctt cgt tct tat tcc 403 Ala Trp Ala Asn Trp Met Trp Val Ala Pro Arg Leu Arg Ser Tyr Ser                  90 95 100 gaa atc tcg gcc aac tca atc acc ctg cct tca ttc ttt gag aac cga 451 Glu Ile Ser Ala Asn Ser Ile Thr Leu Pro Ser Phe Phe Glu Asn Arg             105 110 115 ctt cgc gat aaa tct cgc gcg ctt cgc atc att gca gca cta att atc 499 Leu Arg Asp Lys Ser Arg Ala Leu Arg Ile Ile Ala Ala Leu Ile Ile         120 125 130 att gtg ttc ttc acc ttc tac att tct tca ggc atg gtt gct ggt gga 547 Ile Val Phe Phe Thr Phe Tyr Ile Ser Ser Gly Met Val Ala Gly Gly     135 140 145 gtg tat tgg gag tcc acg ttt ggt gga gat tat cta ctc ggt atg gcc 595 Val Tyr Trp Glu Ser Thr Phe Gly Gly Asp Tyr Leu Leu Gly Met Ala 150 155 160 165 att gtc gca ggt gtg aca gtg ctg tat acc ttc att gga gga ttc ctt 643 Ile Val Ala Gly Val Thr Val Leu Tyr Thr Phe Ile Gly Gly Phe Leu                 170 175 180 gct gtg tct tat aca gac gca gtt cag ggg act atc atg ttc ttc tcg 691 Ala Val Ser Tyr Thr Asp Ala Val Gln Gly Thr Ile Met Phe Phe Ser             185 190 195 ttg atc atc gtg cca gtc atg gca tat ttc gca ctg gcg aac ccc atg 739 Leu Ile Ile Val Pro Val Met Ala Tyr Phe Ala Leu Ala Asn Pro Met         200 205 210 gat att tgg agc ttt gca aac tct aat gat tac ggc ccg cac acc gat 787 Asp Ile Trp Ser Phe Ala Asn Ser Asn Asp Tyr Gly Pro His Thr Asp     215 220 225 gga att ggc aat ccc acc tac ttc tcc atg atc agt ggc att tct gca 835 Gly Ile Gly Asn Pro Thr Tyr Phe Ser Met Ile Ser Gly Ile Ser Ala 230 235 240 245 gca gca atc att ggt aac tta ggt tgg ggt ctt gga tac ttc ggc cag 883 Ala Ala Ile Ile Gly Asn Leu Gly Trp Gly Leu Gly Tyr Phe Gly Gln                 250 255 260 cca cac att gtg gtt cgt ttc atg gca ctt cgc aca cca gct gaa gca 931 Pro His Ile Val Val Arg Phe Met Ala Leu Arg Thr Pro Ala Glu Ala             265 270 275 aag caa ggt cgt cgc atc ggt att tcc tgg atg ata atc tgc ctg att 979 Lys Gln Gly Arg Arg Ile Gly Ile Ser Trp Met Ile Ile Cys Leu Ile         280 285 290 ggt gca acc ttt acc gca att atc tcc aca gtt ttc ttt gca caa aac 1027 Gly Ala Thr Phe Thr Ala Ile Ile Ser Thr Val Phe Phe Ala Gln Asn     295 300 305 ccc gac gcc aac atc act gac aca agg gct tat gag tcc atc ttc cta 1075 Pro Asp Ala Asn Ile Thr Asp Thr Arg Ala Tyr Glu Ser Ile Phe Leu 310 315 320 325 gat ctt gcc cgg atg ctg ttc cac cca ttg atc gct gga ctt att ctg 1123 Asp Leu Ala Arg Met Leu Phe His Pro Leu Ile Ala Gly Leu Ile Leu                 330 335 340 act gct gtt ctc gcg gcc atc atg tct acc atg tcg tca cag ctg ctg 1171 Thr Ala Val Leu Ala Ala Ile Met Ser Thr Met Ser Ser Gln Leu Leu             345 350 355 gtc acc gca tct tcc ctg att gag gac ctg ctg aag gta gtt aaa aag 1219 Val Thr Ala Ser Ser Le Le Ile Glu Asp Leu Leu Lys Val Val Lys Lys         360 365 370 gac tcg ctg agc gaa cgc acc ctg atc atg ctg tct cgt gcc aca gtc 1267 Asp Ser Leu Ser Glu Arg Thr Leu Ile Met Leu Ser Arg Ala Thr Val     375 380 385 atc att ctg gcg atc att gca gca gcc atg gct att aac ccg tct gat 1315 Ile Ile Leu Ala Ile Ile Ala Ala Ala Met Ala Ile Asn Pro Ser Asp 390 395 400 405 tcc atc ctc gga ttg gtg gga ttt gcg tgg gca gga ttc ggc tct gca 1363 Ser Ile Leu Gly Leu Val Gly Phe Ala Trp Ala Gly Phe Gly Ser Ala                 410 415 420 ttt ggt ccg atc ata ctt gct agc ctt tat tgg aag cgt ctc aac gcc 1411 Phe Gly Pro Ile Ile Leu Ala Ser Leu Tyr Trp Lys Arg Leu Asn Ala             425 430 435 gcc ggc gct atc tcc ggc atg att act ggt gct att gtc tcc atc gcg 1459 Ala Gly Ala Ile Ser Gly Met Ile Thr Gly Ala Ile Val Ser Ile Ala         440 445 450 tgg ggt atg tcc cca cta agc gat acg ttg tat gaa atc atc cca ggt 1507 Trp Gly Met Ser Pro Leu Ser Asp Thr Leu Tyr Glu Ile Ile Pro Gly     455 460 465 ttc gcc ttg gca acc atc gtg atg gtc gtt gtt tcc ctc ctg aca aag 1555 Phe Ala Leu Ala Thr Ile Val Met Val Val Val Ser Leu Leu Thr Lys 470 475 480 485 gaa ccc tcc gaa gaa atc ctc aac gag ttt gaa acc gcc aag gat ctt 1603 Glu Pro Ser Glu Glu Ile Leu Asn Glu Phe Glu Thr Ala Lys Asp Leu                 490 495 500 gct gcc gct gtg gaa tca aac gag gat gtt gat ttc gct gac gca gct 1651 Ala Ala Ala Val Glu Ser Asn Glu Asp Val Asp Phe Ala Asp Ala Ala             505 510 515 cag aag ctt tcg aaa gaa agt taagccttag agggaaccaa acg 1695 Gln Lys Leu Ser Lys Glu Ser         520 <210> 496 <211> 524 <212> PRT <213> Corynebacterium glutamicum <400> 496 Met Ser Asp Asn Thr Trp Phe Ile Ila Ala Ile Val Ile Tyr Met Leu   1 5 10 15 Val Met Val Leu Ile Gly Tyr Trp Ser Tyr Arg Lys Thr Glu Lys Tyr              20 25 30 Asp Asp Tyr Met Leu Ala Gly Arg Gly Leu Asn Pro Phe Val Ala Ala          35 40 45 Met Ser Ala Gly Ala Ser Asp Met Ser Gly Trp Leu Leu Met Gly Leu      50 55 60 Pro Gly Ala Leu Phe Val Thr Gly Met Ser Glu Leu Trp Ile Ala Val  65 70 75 80 Gly Leu Thr Ile Gly Ala Trp Ala Asn Trp Met Trp Val Ala Pro Arg                  85 90 95 Leu Arg Ser Tyr Ser Glu Ile Ser Ala Asn Ser Ile Thr Leu Pro Ser             100 105 110 Phe Phe Glu Asn Arg Leu Arg Asp Lys Ser Arg Ala Leu Arg Ile Ile         115 120 125 Ala Ala Leu Ile Ile Ile Val Phe Phe Thr Phe Tyr Ile Ser Ser Gly     130 135 140 Met Val Ala Gly Gly Val Tyr Trp Glu Ser Thr Phe Gly Gly Asp Tyr 145 150 155 160 Leu Leu Gly Met Ala Ile Val Ala Gly Val Thr Val Leu Tyr Thr Phe                 165 170 175 Ile Gly Gly Phe Leu Ala Val Ser Tyr Thr Asp Ala Val Gln Gly Thr             180 185 190 Ile Met Phe Phe Ser Leu Ile Ile Val Pro Val Met Ala Tyr Phe Ala         195 200 205 Leu Ala Asn Pro Met Asp Ile Trp Ser Phe Ala Asn Ser Asn Asp Tyr     210 215 220 Gly Pro His Thr Asp Gly Ile Gly Asn Pro Thr Tyr Phe Ser Met Ile 225 230 235 240 Ser Gly Ile Ser Ala Ala Ala Ile Ile Gly Asn Leu Gly Trp Gly Leu                 245 250 255 Gly Tyr Phe Gly Gln Pro His Ile Val Val Arg Phe Met Ala Leu Arg             260 265 270 Thr Pro Ala Glu Ala Lys Gln Gly Arg Arg Ile Gly Ile Ser Trp Met         275 280 285 Ile Ile Cys Leu Ile Gly Ala Thr Phe Thr Ala Ile Ile Ser Thr Val     290 295 300 Phe Phe Ala Gln Asn Pro Asp Ala Asn Ile Thr Asp Thr Arg Ala Tyr 305 310 315 320 Glu Ser Ile Phe Leu Asp Leu Ala Arg Met Leu Phe His Pro Leu Ile                 325 330 335 Ala Gly Leu Ile Leu Thr Ala Val Leu Ala Ala Ile Met Ser Thr Met             340 345 350 Ser Ser Gln Leu Leu Val Thr Ala Ser Ser Leu Ile Glu Asp Leu Leu         355 360 365 Lys Val Val Lys Lys Asp Ser Leu Ser Glu Arg Thr Leu Ile Met Leu     370 375 380 Ser Arg Ala Thr Val Ile Ile Leu Ala Ile Ile Ala Ala Ala Met Ala 385 390 395 400 Ile Asn Pro Ser Asp Ser Ile Leu Gly Leu Val Gly Phe Ala Trp Ala                 405 410 415 Gly Phe Gly Ser Ala Phe Gly Pro Ile Ile Leu Ala Ser Leu Tyr Trp             420 425 430 Lys Arg Leu Asn Ala Ala Gly Ala Ile Ser Gly Met Ile Thr Gly Ala         435 440 445 Ile Val Ser Ile Ala Trp Gly Met Ser Pro Leu Ser Asp Thr Leu Tyr     450 455 460 Glu Ile Ile Pro Gly Phe Ala Leu Ala Thr Ile Val Met Val Val Val 465 470 475 480 Ser Leu Leu Thr Lys Glu Pro Ser Glu Glu Ile Leu Asn Glu Phe Glu                 485 490 495 Thr Ala Lys Asp Leu Ala Ala Ala Val Glu Ser Asn Glu Asp Val Asp             500 505 510 Phe Ala Asp Ala Ala Gln Lys Leu Ser Lys Glu Ser         515 520 <210> 497 <211> 1476 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1453) <223> RXA00591 <400> 497 gcaacgccac aggcaaaatc caaaagaaca tcctgcgaga cttcaccatc cccgtttcat 60 aaacccccca acgtcacttt gaaaacactt ggagaacgca atg act aca tct tcc 115                                             Met Thr Thr Ser Ser                                               1 5 aca gct tcg ccg atc gct gaa tta caa aac ctc agc ccg aag caa aga 163 Thr Ala Ser Pro Ile Ala Glu Leu Gln Asn Leu Ser Pro Lys Gln Arg                  10 15 20 aaa tca gaa tcc cgg cgc gcg att ata tcc agc tac ttg ggc tcc acg 211 Lys Ser Glu Ser Arg Arg Ala Ile Ile Ser Ser Tyr Leu Gly Ser Thr              25 30 35 atc gag ttc tat gac ttc ctg tta tat gcc gca gcc tcc gcg acg gta 259 Ile Glu Phe Tyr Asp Phe Leu Leu Tyr Ala Ala Ala Ser Ala Thr Val          40 45 50 ttc ccc gca gtg ttc ttt acc aat ctc gat ccg ctg gct gga acc att 307 Phe Pro Ala Val Phe Phe Thr Asn Leu Asp Pro Leu Ala Gly Thr Ile      55 60 65 gcc gcc tac gga acc ttc gcc gca ggt tat tta gct agg cca ctt ggt 355 Ala Ala Tyr Gly Thr Phe Ala Ala Gly Tyr Leu Ala Arg Pro Leu Gly  70 75 80 85 gga gca atc ttc gga cac ttc ggt gac cgt ctt gga cgc aag aag atg 403 Gly Ala Ile Phe Gly His Phe Gly Asp Arg Leu Gly Arg Lys Lys Met                  90 95 100 ctt gtg ttg tcc atg ctc atc atg ggt gtg gca tcc aca tgc atc ggc 451 Leu Val Leu Ser Met Leu Ile Met Gly Val Ala Ser Thr Cys Ile Gly             105 110 115 ctt gtc cca agc gct gaa atg atc gga agc atg ggc gcg gta atc ctg 499 Leu Val Pro Ser Ala Glu Met Ile Gly Ser Met Gly Ala Val Ile Leu         120 125 130 atc atg ctg cgc atc tgc caa ggc atc gct gtc ggt ggc gaa tgg ggc 547 Ile Met Leu Arg Ile Cys Gln Gly Ile Ala Val Gly Gly Glu Trp Gly     135 140 145 gga gct gcc ctc atg gcg ctc gag cac tca gat tcc aag aag cgc gga 595 Gly Ala Ala Leu Met Ala Leu Glu His Ser Asp Ser Lys Lys Arg Gly 150 155 160 165 ttc gcc gcc tcc ttc acc aac gct ggt gca cca acc ggc gct gca ctg 643 Phe Ala Ala Ser Phe Thr Asn Ala Gly Ala Pro Thr Gly Ala Ala Leu                 170 175 180 gga acc ttc gcg ctc ggt acc gca tct gct gtt ctc acc cag gag caa 691 Gly Thr Phe Ala Leu Gly Thr Ala Ser Ala Val Leu Thr Gln Glu Gln             185 190 195 ttc ctt tca tgg ggt tgg cgc atc cca ttc ctg ctc tct ttc gtt ctg 739 Phe Leu Ser Trp Gly Trp Arg Ile Pro Phe Leu Leu Ser Phe Val Leu         200 205 210 ctg att gtc ggc ttg gtt atc cgc gcg aaa gtt agc gaa tca cca ctg 787 Leu Ile Val Gly Leu Val Ile Arg Ala Lys Val Ser Glu Ser Pro Leu     215 220 225 ttc gca gct gca gcg gcc gcc gaa aaa gcc aag cca acc gaa cgt aaa 835 Phe Ala Ala Ala Ala Ala Ala Glu Lys Ala Lys Pro Thr Glu Arg Lys 230 235 240 245 gtc ccc ctc ttg cag gtt ctt cgc cga cca aag gca ctg atc ttg acc 883 Val Pro Leu Leu Gln Val Leu Arg Arg Pro Lys Ala Leu Ile Leu Thr                 250 255 260 atg ctt ggc ggc gca tca gga ttc gga ctt caa gtt ctc ttg tcc acc 931 Met Leu Gly Gly Ala Ser Gly Phe Gly Leu Gln Val Leu Leu Ser Thr             265 270 275 ttc tcc atc agc tac gca aca caa tcc ggc atc gaa aga tcc agc gtc 979 Phe Ser Ile Ser Tyr Ala Thr Gln Ser Gly Ile Glu Arg Ser Ser Val         280 285 290 ctc tac gcc ttc gca gtc gcc tca gtg ttc tct gtc ttc ttt gtg atc 1027 Leu Tyr Ala Phe Ala Val Ala Ser Val Phe Ser Val Phe Phe Val Ile     295 300 305 ctc ttc ggt cgc gta tcc gac ctc ttc gga cgc cga ccc gtc atg atc 1075 Leu Phe Gly Arg Val Ser Asp Leu Phe Gly Arg Arg Pro Val Met Ile 310 315 320 325 atc gcg ctc gta ctg ttc gtg gcc tac ctg ccg gca ttc ttc cgg atg 1123 Ile Ala Leu Val Leu Phe Val Ala Tyr Leu Pro Ala Phe Phe Arg Met                 330 335 340 ctc acc tca gac aac tgg ttc atc ctg ctc tcg gca ttc acc atc gcg 1171 Leu Thr Ser Asp Asn Trp Phe Ile Leu Leu Ser Ala Phe Thr Ile Ala             345 350 355 ctc gca ctc cac gcc atg ctt tac ggc cca cta gca gcg ttt atc tcc 1219 Leu Ala Leu His Ala Met Leu Tyr Gly Pro Leu Ala Ala Phe Ile Ser         360 365 370 gaa caa ttc gga acc tcc gcg cgc tac aca ggc gca tcc ctg ggt tac 1267 Glu Gln Phe Gly Thr Ser Ala Arg Tyr Thr Gly Ala Ser Leu Gly Tyr     375 380 385 cag ttg gcc acg ctc atc ggt gca gga ttc acc cca acc atc ctg gct 1315 Gln Leu Ala Thr Leu Ile Gly Ala Gly Phe Thr Pro Thr Ile Leu Ala 390 395 400 405 agc ctc tac gcg gga cca ggc ggc gga acc tct gtc acc cca gtc atc 1363 Ser Leu Tyr Ala Gly Pro Gly Gly Gly Thr Ser Val Thr Pro Val Ile                 410 415 420 gtc ttc ctc gca acg atg tcc cta gtg tcc atc atc gcc atc gca atc 1411 Val Phe Leu Ala Thr Met Ser Leu Val Ser Ile Ile Ala Ile Ala Ile             425 430 435 acc aga gaa tca aaa gac cac gat ctt tct act tac gaa cac 1453 Thr Arg Glu Ser Lys Asp His Asp Leu Ser Thr Tyr Glu His         440 445 450 taaggggacg atagggtcaa ttt 1476 <210> 498 <211> 451 <212> PRT <213> Corynebacterium glutamicum <400> 498 Met Thr Thr Ser Ser Thr Ala Ser Pro Ile Ala Glu Leu Gln Asn Leu   1 5 10 15 Ser Pro Lys Gln Arg Lys Ser Glu Ser Arg Arg Ala Ile Ile Ser Ser              20 25 30 Tyr Leu Gly Ser Thr Ile Glu Phe Tyr Asp Phe Leu Leu Tyr Ala Ala          35 40 45 Ala Ser Ala Thr Val Phe Pro Ala Val Phe Phe Thr Asn Leu Asp Pro      50 55 60 Leu Ala Gly Thr Ile Ala Ala Tyr Gly Thr Phe Ala Ala Gly Tyr Leu  65 70 75 80 Ala Arg Pro Leu Gly Gly Ala Ile Phe Gly His Phe Gly Asp Arg Leu                  85 90 95 Gly Arg Lys Lys Met Leu Val Leu Ser Met Leu Ile Met Gly Val Ala             100 105 110 Ser Thr Cys Ile Gly Leu Val Pro Ser Ala Glu Met Ile Gly Ser Met         115 120 125 Gly Ala Val Ile Leu Ile Met Leu Arg Ile Cys Gln Gly Ile Ala Val     130 135 140 Gly Gly Glu Trp Gly Gly Ala Ala Leu Met Ala Leu Glu His Ser Asp 145 150 155 160 Ser Lys Lys Arg Gly Phe Ala Ala Ser Phe Thr Asn Ala Gly Ala Pro                 165 170 175 Thr Gly Ala Ala Leu Gly Thr Phe Ala Leu Gly Thr Ala Ser Ala Val             180 185 190 Leu Thr Gln Glu Gln Phe Leu Ser Trp Gly Trp Arg Ile Pro Phe Leu         195 200 205 Leu Ser Phe Val Leu Leu Ile Val Gly Leu Val Ile Arg Ala Lys Val     210 215 220 Ser Glu Ser Pro Leu Phe Ala Ala Ala Ala Ala Ala Glu Lys Ala Lys 225 230 235 240 Pro Thr Glu Arg Lys Val Pro Leu Leu Gln Val Leu Arg Arg Pro Lys                 245 250 255 Ala Leu Ile Leu Thr Met Leu Gly Gly Ala Ser Gly Phe Gly Leu Gln             260 265 270 Val Leu Leu Ser Thr Phe Ser Ile Ser Tyr Ala Thr Gln Ser Gly Ile         275 280 285 Glu Arg Ser Ser Val Leu Tyr Ala Phe Ala Val Ala Ser Val Phe Ser     290 295 300 Val Phe Phe Val Ile Leu Phe Gly Arg Val Ser Asp Leu Phe Gly Arg 305 310 315 320 Arg Pro Val Met Ile Ile Ala Leu Val Leu Phe Val Ala Tyr Leu Pro                 325 330 335 Ala Phe Phe Arg Met Leu Thr Ser Asp Asn Trp Phe Ile Leu Leu Ser             340 345 350 Ala Phe Thr Ile Ala Leu Ala Leu His Ala Met Leu Tyr Gly Pro Leu         355 360 365 Ala Ala Phe Ile Ser Glu Gln Phe Gly Thr Ser Ala Arg Tyr Thr Gly     370 375 380 Ala Ser Leu Gly Tyr Gln Leu Ala Thr Leu Ile Gly Ala Gly Phe Thr 385 390 395 400 Pro Thr Ile Leu Ala Ser Leu Tyr Ala Gly Pro Gly Gly Gly Thr Ser                 405 410 415 Val Thr Pro Val Ile Val Phe Leu Ala Thr Met Ser Leu Val Ser Ile             420 425 430 Ile Ala Ile Ala Ile Thr Arg Glu Ser Lys Asp His Asp Leu Ser Thr         435 440 445 Tyr Glu His     450 <210> 499 <211> 1635 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1612) <223> RXA01629 <400> 499 caggaagaag ttaacaccgc ccaggggtgc gttggatgat gatcatctac aaacaaacat 60 tccgttatgc actcataaga tatgacgaga ggttttactc gtg agc ccg att cgc 115                                             Val Ser Pro Ile Arg                                               1 5 tca aaa aag aaa atc aag aac gaa cca aga cta aca gtc gat gac gtc 163 Ser Lys Lys Lys Ile Lys Asn Glu Pro Arg Leu Thr Val Asp Asp Val                  10 15 20 aac gtt gtt ccc cca aag aag atc cgt ccg gcc att aaa ggc act gtg 211 Asn Val Val Pro Pro Lys Lys Ile Arg Pro Ala Ile Lys Gly Thr Val              25 30 35 gtg ggt aac ttc atg gag tgg tac gac ttc gga att tat ggt tat ttg 259 Val Gly Asn Phe Met Glu Trp Tyr Asp Phe Gly Ile Tyr Gly Tyr Leu          40 45 50 acg gtc acg atg acc gca gta ttt acc caa ggc ctg ccg caa gaa tgg 307 Thr Val Thr Met Thr Ala Val Phe Thr Gln Gly Leu Pro Gln Glu Trp      55 60 65 cag ttg ttg gcc gtg atg ttt ggt ttc gcg gtg tct tat tta gtt cgc 355 Gln Leu Leu Ala Val Met Phe Gly Phe Ala Val Ser Tyr Leu Val Arg  70 75 80 85 ccg ctt ggt ggc ctg gtt ctg ggt ccg ctt ggc gat aag gtt ggc cgc 403 Pro Leu Gly Gly Leu Val Leu Gly Pro Leu Gly Asp Lys Val Gly Arg                  90 95 100 cag aag gtt ttg tac gta acc atg gcc atg atg gcc gtg tct acg gcg 451 Gln Lys Val Leu Tyr Val Thr Met Ala Met Met Ala Val Ser Thr Ala             105 110 115 ctg att ggc ttg ctg ccg acg gcg gcg tcg ata ggc gct tgg gct ttg 499 Leu Ile Gly Leu Leu Pro Thr Ala Ala Ser Ile Gly Ala Trp Ala Leu         120 125 130 gtg ctt ttg tac ctg ttg aag atg gtg cag gga ttt tcg act ggt ggt 547 Val Leu Leu Tyr Leu Leu Lys Met Val Gln Gly Phe Ser Thr Gly Gly     135 140 145 gaa tat gct ggt gcg acc acc tat gtt gct gag ttt gcg ccg gat cgt 595 Glu Tyr Ala Gly Ala Thr Thr Tyr Val Ala Glu Phe Ala Pro Asp Arg 150 155 160 165 cga cga ggt ttc ttc gga gct ttc cta gat atg ggt tcc tac ctg ggc 643 Arg Arg Gly Phe Phe Gly Ala Phe Leu Asp Met Gly Ser Tyr Leu Gly                 170 175 180 ttt gcc gcg ggt gct tcg gtc gtg gcg att act acc tgg gtg acc act 691 Phe Ala Ala Gly Ala Ser Val Val Ala Ile Thr Thr Trp Val Thr Thr             185 190 195 cac ttc tat ggc gca act gcc atg gag gat ttc ggt tgg cgt att cct 739 His Phe Tyr Gly Ala Thr Ala Met Glu Asp Phe Gly Trp Arg Ile Pro         200 205 210 ttc ctg act gcg atc ccg ctg ggc atc att gcg gtg tac ctg cgt act 787 Phe Leu Thr Ala Ile Pro Leu Gly Ile Ile Ala Val Tyr Leu Arg Thr     215 220 225 cgt atc cct gag acc cct gcg ttt gag aac aac caa gac gag cca aat 835 Arg Ile Pro Glu Thr Pro Ala Phe Glu Asn Asn Gln Asp Glu Pro Asn 230 235 240 245 gca gtt gtt gaa aag gac act gaa gat cct tat gca cgc ctg ggc ctg 883 Ala Val Val Glu Lys Asp Thr Glu Asp Pro Tyr Ala Arg Leu Gly Leu                 250 255 260 gct ggt gtt atc cgc cac cac tgg cgt cca ctg ctg att ggt att gcg 931 Ala Gly Val Ile Arg His His Trp Arg Pro Leu Leu Ile Gly Ile Ala             265 270 275 att gtg gca gcg acc aac acc gcc ggt tac gcg cta acc agt tac atg 979 Ile Val Ala Ala Thr Asn Thr Ala Gly Tyr Ala Leu Thr Ser Tyr Met         280 285 290 cct gtg tat cta gag gag cag atc ggt ctg cac tcc gca tcc gct gcc 1027 Pro Val Tyr Leu Glu Glu Gln Ile Gly Leu His Ser Ala Ser Ala Ala     295 300 305 gct gtg acc gtg ccg att ctg gtt gtt atg tcc ctg ctg ctg cca ttt 1075 Ala Val Thr Val Pro Ile Leu Val Val Met Ser Leu Leu Leu Pro Phe 310 315 320 325 gtt ggt atg tgg agt gac cgc gtg ggc cgc aag cct gtc tac gcg act 1123 Val Gly Met Trp Ser Asp Arg Val Gly Arg Lys Pro Val Tyr Ala Thr                 330 335 340 gct gtt gcg gca acg ctg atc ttg atg gtt cct gcc ttc ttg atc atg 1171 Ala Val Ala Ala Thr Leu Ile Leu Met Val Pro Ala Phe Leu Ile Met             345 350 355 aac acc gga acc atc ggc gcc gta ctg att gca ctg tcc atg gtt gct 1219 Asn Thr Gly Thr Ile Gly Ala Val Leu Ile Ala Leu Ser Met Val Ala         360 365 370 att cca acc ggt ttg tat gtg gca ctg tcc gca tct gcc ctg cca gcg 1267 Ile Pro Thr Gly Leu Tyr Val Ala Leu Ser Ala Ser Ala Leu Pro Ala     375 380 385 ctg ttc cca acc gcg tca cga ttc tct gga atg ggt att tcc tac aac 1315 Leu Phe Pro Thr Ala Ser Arg Phe Ser Gly Met Gly Ile Ser Tyr Asn 390 395 400 405 att tcc gtg tcg ttg ttc ggt ggt aca acc ccg ctg atc acc cag ttc 1363 Ile Ser Val Ser Leu Phe Gly Gly Thr Thr Pro Leu Ile Thr Gln Phe                 410 415 420 ctg ctg cag aag act ggc ctg gat atc gtt cca gcg ctc tac atc atg 1411 Leu Leu Gln Lys Thr Gly Leu Asp Ile Val Pro Ala Leu Tyr Ile Met             425 430 435 ttc ttc tct gca atc gca ggt gtg gcg ctg ctg ttc atg acc gag tct 1459 Phe Phe Ser Ala Ile Ala Gly Val Ala Leu Leu Phe Met Thr Glu Ser         440 445 450 tca cag aag cca ctg ctt ggc tca ttc cca acc gtg gaa acc aag tct 1507 Ser Gln Lys Pro Leu Leu Gly Ser Phe Pro Thr Val Glu Thr Lys Ser     455 460 465 gag gcc gtg gag atc gtg aag aac cag gac gag gat cca aat att gat 1555 Glu Ala Val Glu Ile Val Lys Asn Gln Asp Glu Asp Pro Asn Ile Asp 470 475 480 485 ctt tcc cat atg ccg ttt cct gat gag gaa aac gta ggt gct gaa aag 1603 Leu Ser His Met Pro Phe Pro Asp Glu Glu Asn Val Gly Ala Glu Lys                 490 495 500 caa aac gca taaccgtaaa gcccgctgca agg 1635 Gln asn ala <210> 500 <211> 504 <212> PRT <213> Corynebacterium glutamicum <400> 500 Val Ser Pro Ile Arg Ser Lys Lys Lys Ile Lys Asn Glu Pro Arg Leu   1 5 10 15 Thr Val Asp Asp Val Asn Val Val Pro Pro Lys Lys Ile Arg Pro Ala              20 25 30 Ile Lys Gly Thr Val Val Gly Asn Phe Met Glu Trp Tyr Asp Phe Gly          35 40 45 Ile Tyr Gly Tyr Leu Thr Val Thr Met Thr Ala Val Phe Thr Gln Gly      50 55 60 Leu Pro Gln Glu Trp Gln Leu Leu Ala Val Met Phe Gly Phe Ala Val  65 70 75 80 Ser Tyr Leu Val Arg Pro Leu Gly Gly Leu Val Leu Gly Pro Leu Gly                  85 90 95 Asp Lys Val Gly Arg Gln Lys Val Leu Tyr Val Thr Met Ala Met Met             100 105 110 Ala Val Ser Thr Ala Leu Ile Gly Leu Leu Pro Thr Ala Ala Ser Ile         115 120 125 Gly Ala Trp Ala Leu Val Leu Leu Tyr Leu Leu Lys Met Val Gln Gly     130 135 140 Phe Ser Thr Gly Gly Glu Tyr Ala Gly Ala Thr Thr Tyr Val Ala Glu 145 150 155 160 Phe Ala Pro Asp Arg Arg Arg Gly Phe Phe Gly Ala Phe Leu Asp Met                 165 170 175 Gly Ser Tyr Leu Gly Phe Ala Ala Gly Ala Ser Val Val Ala Ile Thr             180 185 190 Thr Trp Val Thr Thr His Phe Tyr Gly Ala Thr Ala Met Glu Asp Phe         195 200 205 Gly Trp Arg Ile Pro Phe Leu Thr Ala Ile Pro Leu Gly Ile Ile Ala     210 215 220 Val Tyr Leu Arg Thr Arg Ile Pro Glu Thr Pro Ala Phe Glu Asn Asn 225 230 235 240 Gln Asp Glu Pro Asn Ala Val Val Glu Lys Asp Thr Glu Asp Pro Tyr                 245 250 255 Ala Arg Leu Gly Leu Ala Gly Val Ile Arg His His Trp Arg Pro Leu             260 265 270 Leu Ile Gly Ile Ala Ile Val Ala Ala Thr Asn Thr Ala Gly Tyr Ala         275 280 285 Leu Thr Ser Tyr Met Pro Val Tyr Leu Glu Glu Gln Ile Gly Leu His     290 295 300 Ser Ala Ser Ala Ala Ala Val Thr Val Pro Ile Leu Val Val Met Ser 305 310 315 320 Leu Leu Leu Pro Phe Val Gly Met Trp Ser Asp Arg Val Gly Arg Lys                 325 330 335 Pro Val Tyr Ala Thr Ala Val Ala Ala Thr Leu Ile Leu Met Val Pro             340 345 350 Ala Phe Leu Ile Met Asn Thr Gly Thr Ile Gly Ala Val Leu Ile Ala         355 360 365 Leu Ser Met Val Ala Ile Pro Thr Gly Leu Tyr Val Ala Leu Ser Ala     370 375 380 Ser Ala Leu Pro Ala Leu Phe Pro Thr Ala Ser Arg Phe Ser Gly Met 385 390 395 400 Gly Ile Ser Tyr Asn Ile Ser Val Ser Leu Phe Gly Gly Thr Thr Pro                 405 410 415 Leu Ile Thr Gln Phe Leu Leu Gln Lys Thr Gly Leu Asp Ile Val Pro             420 425 430 Ala Leu Tyr Ile Met Phe Phe Ser Ala Ile Ala Gly Val Ala Leu Leu         435 440 445 Phe Met Thr Glu Ser Ser Gln Lys Pro Leu Leu Gly Ser Phe Pro Thr     450 455 460 Val Glu Thr Lys Ser Glu Ala Val Glu Ile Val Lys Asn Gln Asp Glu 465 470 475 480 Asp Pro Asn Ile Asp Leu Ser His Met Pro Phe Pro Asp Glu Glu Asn                 485 490 495 Val Gly Ala Glu Lys Gln Asn Ala             500 <210> 501 <211> 1509 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (1486) <223> RXA02030 <400> 501 gcgcctaaca tctcattgta tgggattgac tctaataatc tcctgtggaa acatcgcaag 60 ggtaattatt ggaatctatt attgtgtgag gcgataactc gtg acc aca act gat 115                                             Val Thr Thr Thr Asp                                               1 5 cac tcc acg gag ttg aat cct tct gat cca ggt ggg cag acg gca acc 163 His Ser Thr Glu Leu Asn Pro Ser Asp Pro Gly Gly Gln Thr Ala Thr                  10 15 20 cta gtg att gac aag aaa act aaa cgt cgg gtt gca gca gcc tcc acc 211 Leu Val Ile Asp Lys Lys Thr Lys Arg Arg Val Ala Ala Ala Ser Thr              25 30 35 atc ggc aca acc atc gag ttc tac gat ttt tat gcg tac gct gcg gca 259 Ile Gly Thr Thr Ile Glu Phe Tyr Asp Phe Tyr Ala Tyr Ala Ala Ala          40 45 50 gct gtc gtt gtt ttc cca agt ctg ttt ttc cct gcc aat gac aac cca 307 Ala Val Val Val Phe Pro Ser Leu Phe Phe Pro Ala Asn Asp Asn Pro      55 60 65 acc gtg aac ctg ttg gca tcg ttt gcc acc ttt ggt ctt gcg ttc gtt 355 Thr Val Asn Leu Leu Ala Ser Phe Ala Thr Phe Gly Leu Ala Phe Val  70 75 80 85 gct cgt cca ctc ggt tca atc att ttc ggg cac ttc ggt gac cgt gtg 403 Ala Arg Pro Leu Gly Ser Ile Ile Phe Gly His Phe Gly Asp Arg Val                  90 95 100 gga cgc aaa gct acc ttg atc ggt tca ctg ctg acc atg ggc att gcc 451 Gly Arg Lys Ala Thr Leu Ile Gly Ser Leu Leu Thr Met Gly Ile Ala             105 110 115 acc atc ttg atc ggc ctg ctg cct act tat ggt cag gtc gga atc att 499 Thr Ile Leu Ile Gly Leu Leu Pro Thr Tyr Gly Gln Val Gly Ile Ile         120 125 130 gca ccg gcg ctg ttg gcg ctc atg cgt ttc tgc cag ggc ctg ggc ctt 547 Ala Pro Ala Leu Leu Ala Leu Met Arg Phe Cys Gln Gly Leu Gly Leu     135 140 145 ggc ggt gaa tgg tct ggc gct gcg ttg ctg gct ggt gaa aac gcg gaa 595 Gly Gly Glu Trp Ser Gly Ala Ala Leu Leu Ala Gly Glu Asn Ala Glu 150 155 160 165 aac act cac cgc gct cgt gct gca atg tgg cca cag ctg ggt gca ccg 643 Asn Thr His Arg Ala Arg Ala Ala Met Trp Pro Gln Leu Gly Ala Pro                 170 175 180 ttt ggt ttc ttc ttg gcc aat ggt ttc atg ctc att ctg gtc ggt gtg 691 Phe Gly Phe Phe Leu Ala Asn Gly Phe Met Leu Ile Leu Val Gly Val             185 190 195 ctt gcc cat cag gac ggc gat ctt cac ggc gcg ttc atg acc tgg ggt 739 Leu Ala His Gln Asp Gly Asp Leu His Gly Ala Phe Met Thr Trp Gly         200 205 210 tgg cgt ctg cca ttc ctg tct tcg gcg atc atg atc gca gtt ggc ctg 787 Trp Arg Leu Pro Phe Leu Ser Ser Ala Ile Met Ile Ala Val Gly Leu     215 220 225 tgg gtg cgt ttc tca ctg gag gaa act cca gtg ttc aag cag gct gtt 835 Trp Val Arg Phe Ser Leu Glu Glu Thr Pro Val Phe Lys Gln Ala Val 230 235 240 245 gat cag ggc aag aag gtg aag tct ccg ctc aag gag ctg ttc aag act 883 Asp Gln Gly Lys Lys Val Lys Ser Pro Leu Lys Glu Leu Phe Lys Thr                 250 255 260 tcc cct ggc cct gtt gtg cag gct act ttg atc atg ctg tcc act tat 931 Ser Pro Gly Pro Val Val Gln Ala Thr Leu Ile Met Leu Ser Thr Tyr             265 270 275 acc ttg ttc tac ctg gtt acc acg tgg att ctg tcg tat ggc atc ggt 979 Thr Leu Phe Tyr Leu Val Thr Thr Trp Ile Leu Ser Tyr Gly Ile Gly         280 285 290 aat cgc agc acc gga aac ggc ctg tct att ccg tac ttt gag ttc ttg 1027 Asn Arg Ser Thr Gly Asn Gly Leu Ser Ile Pro Tyr Phe Glu Phe Leu     295 300 305 cag ttg cag ctg gcc acc atc gtg ttc ttc gcc atc atg atc cct gtg 1075 Gln Leu Gln Leu Ala Thr Ile Val Phe Phe Ala Ile Met Ile Pro Val 310 315 320 325 tca ggc tgg ttg gct gat gtg tgg ggt cgt aaa aac acc ctg acc ttg 1123 Ser Gly Trp Leu Ala Asp Val Trp Gly Arg Lys Asn Thr Leu Thr Leu                 330 335 340 gct tct gtg ctg ctt ctc ggc ttt ggt ctg acg ttt aat ctg ctt ctc 1171 Ala Ser Val Leu Leu Leu Gly Phe Gly Leu Thr Phe Asn Leu Leu Leu             345 350 355 gat cca gag acc gcc acc aag acc acc gtg ttc atc ttc ttg ttc gtg 1219 Asp Pro Glu Thr Ala Thr Lys Thr Thr Val Phe Ile Phe Leu Phe Val         360 365 370 ggc atg agc atc atg ggt ctg atc ttt gga ccc atg tcg gca att ttg 1267 Gly Met Ser Ile Met Gly Leu Ile Phe Gly Pro Met Ser Ala Ile Leu     375 380 385 ccg gag ctc ttc ccc acc aac gtc cgc tac acg ggc tcc gga atc gcc 1315 Pro Glu Leu Phe Pro Thr Asn Val Arg Tyr Thr Gly Ser Gly Ile Ala 390 395 400 405 tac aat gtc tcc tcg atc ctc ggt gca gct att gca ccg ttc atc gca 1363 Tyr Asn Val Ser Ser Ile Leu Gly Ala Ala Ile Ala Pro Phe Ile Ala                 410 415 420 acg tgg ctg gtg tcc gag ttt tca gtg gcg tac gtc ggc tat tac ctc 1411 Thr Trp Leu Val Ser Glu Phe Ser Val Ala Tyr Val Gly Tyr Tyr Leu             425 430 435 atc atc gtc acc gca att acc ttt gtt gcg gtg ctg acg atg aag gaa 1459 Ile Ile Val Thr Ala Ile Thr Phe Val Ala Val Leu Thr Met Lys Glu         440 445 450 aac aaa aac cac gac ctc cga gag gtc taaaagattt ttgcttatcg 1506 Asn Lys Asn His Asp Leu Arg Glu Val     455 460 acg 1509 <210> 502 <211> 462 <212> PRT <213> Corynebacterium glutamicum <400> 502 Val Thr Thr Thr Asp His Ser Thr Glu Leu Asn Pro Ser Asp Pro Gly   1 5 10 15 Gly Gln Thr Ala Thr Leu Val Ile Asp Lys Lys Thr Lys Arg Arg Val              20 25 30 Ala Ala Ala Ser Thr Ile Gly Thr Thr Ile Glu Phe Tyr Asp Phe Tyr          35 40 45 Ala Tyr Ala Ala Ala Ala Val Val Val Phe Pro Ser Leu Phe Phe Pro      50 55 60 Ala Asn Asp Asn Pro Thr Val Asn Leu Leu Ala Ser Phe Ala Thr Phe  65 70 75 80 Gly Leu Ala Phe Val Ala Arg Pro Leu Gly Ser Ile Ile Phe Gly His                  85 90 95 Phe Gly Asp Arg Val Gly Arg Lys Ala Thr Leu Ile Gly Ser Leu Leu             100 105 110 Thr Met Gly Ile Ala Thr Ile Leu Ile Gly Leu Leu Pro Thr Tyr Gly         115 120 125 Gln Val Gly Ile Ile Ala Pro Ala Leu Leu Ala Leu Met Arg Phe Cys     130 135 140 Gln Gly Leu Gly Leu Gly Gly Glu Trp Ser Gly Ala Ala Leu Leu Ala 145 150 155 160 Gly Glu Asn Ala Glu Asn Thr His Arg Ala Arg Ala Ala Met Trp Pro                 165 170 175 Gln Leu Gly Ala Pro Phe Gly Phe Phe Leu Ala Asn Gly Phe Met Leu             180 185 190 Ile Leu Val Gly Val Leu Ala His Gln Asp Gly Asp Leu His Gly Ala         195 200 205 Phe Met Thr Trp Gly Trp Arg Leu Pro Phe Leu Ser Ser Ala Ile Met     210 215 220 Ile Ala Val Gly Leu Trp Val Arg Phe Ser Leu Glu Glu Thr Pro Val 225 230 235 240 Phe Lys Gln Ala Val Asp Gln Gly Lys Lys Val Lys Ser Pro Leu Lys                 245 250 255 Glu Leu Phe Lys Thr Ser Pro Gly Pro Val Val Gln Ala Thr Leu Ile             260 265 270 Met Leu Ser Thr Tyr Thr Leu Phe Tyr Leu Val Thr Thr Trp Ile Leu         275 280 285 Ser Tyr Gly Ile Gly Asn Arg Ser Thr Gly Asn Gly Leu Ser Ile Pro     290 295 300 Tyr Phe Glu Phe Leu Gln Leu Gln Leu Ala Thr Ile Val Phe Phe Ala 305 310 315 320 Ile Met Ile Pro Val Ser Gly Trp Leu Ala Asp Val Trp Gly Arg Lys                 325 330 335 Asn Thr Leu Thr Leu Ala Ser Val Leu Leu Leu Gly Phe Gly Leu Thr             340 345 350 Phe Asn Leu Leu Leu Asp Pro Glu Thr Ala Thr Lys Thr Thr Val Phe         355 360 365 Ile Phe Leu Phe Val Gly Met Ser Ile Met Gly Leu Ile Phe Gly Pro     370 375 380 Met Ser Ala Ile Leu Pro Glu Leu Phe Pro Thr Asn Val Arg Tyr Thr 385 390 395 400 Gly Ser Gly Ile Ala Tyr Asn Val Ser Ser Ile Leu Gly Ala Ala Ile                 405 410 415 Ala Pro Phe Ile Ala Thr Trp Leu Val Ser Glu Phe Ser Val Ala Tyr             420 425 430 Val Gly Tyr Tyr Leu Ile Ile Val Thr Ala Ile Thr Phe Val Ala Val         435 440 445 Leu Thr Met Lys Glu Asn Lys Asn His Asp Leu Arg Glu Val     450 455 460 <210> 503 <211> 870 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (847) <223> RXA00186 <400> 503 agaagcccag cattttgttt agctcacctc taaagctcct gatctggata cgaggactcc 60 tgcggaaaac cgtgtggcta gtgaagctac ccggcatctc atg ggg gag aag act 115                                             Met Gly Glu Lys Thr                                               1 5 tct gtc gcg tat gtt cac gat gtt ctg atc aag ggc gtg cca gtg cgg 163 Ser Val Ala Tyr Val His Asp Val Leu Ile Lys Gly Val Pro Val Arg                  10 15 20 ata tac aat ccg cac ccc aac gac ggg ccg ctt cct gtc ttt atc tac 211 Ile Tyr Asn Pro His Pro Asn Asp Gly Pro Leu Pro Val Phe Ile Tyr              25 30 35 ttc cat ggt ggc gga tgg gtt ttg ggg gac ctt gaa tca gtg gat tcc 259 Phe His Gly Gly Gly Trp Val Leu Gly Asp Leu Glu Ser Val Asp Ser          40 45 50 acc gtg cgc gat att gcc gtt gct tca ggc gcc ctg tgt atc agt gtg 307 Thr Val Arg Asp Ile Ala Val Ala Ser Gly Ala Leu Cys Ile Ser Val      55 60 65 gat tat cgc cgt gca ccg gaa cat cct ttt ctc gct gca ttg gat gat 355 Asp Tyr Arg Arg Ala Pro Glu His Pro Phe Leu Ala Ala Leu Asp Asp  70 75 80 85 tgc caa gtg gtc acg gaa gct gtc ctc aat ggt gaa ctc gcc agt gct 403 Cys Gln Val Val Thr Glu Ala Val Leu Asn Gly Glu Leu Ala Ser Ala                  90 95 100 aac cag cat cta gtg gca gtc ggc ggg gac agc gcc ggt ggc aat att 451 Asn Gln His Leu Val Ala Val Gly Gly Asp Ser Ala Gly Gly Asn Ile             105 110 115 gcg gcg gtc atc gct caa cag ctg cgc gat cag atc acc cac caa gtt 499 Ala Ala Val Ile Ala Gln Gln Leu Arg Asp Gln Ile Thr His Gln Val         120 125 130 ctt gtg tat ccg gtg atg gac gta atc ttg ctg gtg att tgt tct atc 547 Leu Val Tyr Pro Val Met Asp Val Ile Leu Leu Val Ile Cys Ser Ile     135 140 145 att acc act ggt ttt gcg ctg ctc atg cat cca aag agc aag gac aag 595 Ile Thr Thr Gly Phe Ala Leu Leu Met His Pro Lys Ser Lys Asp Lys 150 155 160 165 acg gag acg att tct gat gaa ttc ctc gca gag atc caa gcg gga agt 643 Thr Glu Thr Ile Ser Asp Glu Phe Leu Ala Glu Ile Gln Ala Gly Ser                 170 175 180 gaa aag atc tcc att ctg cgt tcg acc cct gct gaa aaa gcc aat gcg 691 Glu Lys Ile Ser Ile Leu Arg Ser Thr Pro Ala Glu Lys Ala Asn Ala             185 190 195 agc cgt tgg atc atg tac ttc gtt ggc gga att ggc ctg ctc tac agc 739 Ser Arg Trp Ile Met Tyr Phe Val Gly Gly Ile Gly Leu Leu Tyr Ser         200 205 210 gtg ttc agc ctg tgg aca ggt ggc gta acc gga ctg acg ttg aac tcc 787 Val Phe Ser Leu Trp Thr Gly Gly Val Thr Gly Leu Thr Leu Asn Ser     215 220 225 ttc aac ttc ctg ttc ctg tca ctc ggc atg gtg ctc acc gct aat tac 835 Phe Asn Phe Leu Phe Leu Ser Leu Gly Met Val Leu Thr Ala Asn Tyr 230 235 240 245 ggg cca gag tat taagcaaagc ttattcgcga agg 870 Gly Pro Glu Tyr <210> 504 <211> 249 <212> PRT <213> Corynebacterium glutamicum <400> 504 Met Gly Glu Lys Thr Ser Val Ala Tyr Val His Asp Val Leu Ile Lys   1 5 10 15 Gly Val Pro Val Arg Ile Tyr Asn Pro His Pro Asn Asp Gly Pro Leu              20 25 30 Pro Val Phe Ile Tyr Phe His Gly Gly Gly Trp Val Leu Gly Asp Leu          35 40 45 Glu Ser Val Asp Ser Thr Val Arg Asp Ile Ala Val Ala Ser Gly Ala      50 55 60 Leu Cys Ile Ser Val Asp Tyr Arg Arg Ala Pro Glu His Pro Phe Leu  65 70 75 80 Ala Ala Leu Asp Asp Cys Gln Val Val Thr Glu Ala Val Leu Asn Gly                  85 90 95 Glu Leu Ala Ser Ala Asn Gln His Leu Val Ala Val Gly Gly Asp Ser             100 105 110 Ala Gly Gly Asn Ile Ala Ala Val Ile Ala Gln Gln Leu Arg Asp Gln         115 120 125 Ile Thr His Gln Val Leu Val Tyr Pro Val Met Asp Val Ile Leu Leu     130 135 140 Val Ile Cys Ser Ile Ile Thr Thr Gly Phe Ala Leu Leu Met His Pro 145 150 155 160 Lys Ser Lys Asp Lys Thr Glu Thr Ile Ser Asp Glu Phe Leu Ala Glu                 165 170 175 Ile Gln Ala Gly Ser Glu Lys Ile Ser Ile Leu Arg Ser Thr Pro Ala             180 185 190 Glu Lys Ala Asn Ala Ser Arg Trp Ile Met Tyr Phe Val Gly Gly Ile         195 200 205 Gly Leu Leu Tyr Ser Val Phe Ser Leu Trp Thr Gly Gly Val Thr Gly     210 215 220 Leu Thr Leu Asn Ser Phe Asn Phe Leu Phe Leu Ser Leu Gly Met Val 225 230 235 240 Leu Thr Ala Asn Tyr Gly Pro Glu Tyr                 245 <210> 505 <211> 468 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (451) <223> RXA00187 <400> 505 gcttattcgc gaaggcatcc aaggaacgtg gggattcatt cttcaattcc cgttctacgc 60 aggcattttc gggttgattt ccttcaccgg tctgggtgtt gtg atc tcc gga ttt 115                                             Val Ile Ser Gly Phe                                               1 5 ttc acc tcg att tcc acg gca acc acg tgg cct gtc atc gcg ttc ctc 163 Phe Thr Ser Ile Ser Thr Ala Thr Thr Trp Pro Val Ile Ala Phe Leu                  10 15 20 tac tct gga ctg ctc aac atc gcg gtg cct tca ggt ggc tcg aaa ttc 211 Tyr Ser Gly Leu Leu Asn Ile Ala Val Pro Ser Gly Gly Ser Lys Phe              25 30 35 atc atc gaa gcc ccg tac atc atc cca acc cca gtg gat ctt ggc gct 259 Ile Ile Glu Ala Pro Tyr Ile Ile Pro Thr Pro Val Asp Leu Gly Ala          40 45 50 gac atg ggc ctt gtc ctg cag gct tat caa atg agt gat ggc gcg acc 307 Asp Met Gly Leu Val Leu Gln Ala Tyr Gln Met Ser Asp Gly Ala Thr      55 60 65 aac ctg ctc att ccg ttc ttc gcg ctg cca tat ttg gcc aat ttc aag 355 Asn Leu Leu Ile Pro Phe Phe Ala Leu Pro Tyr Leu Ala Asn Phe Lys  70 75 80 85 atc aaa ttc agc caa gtg gtg ggc tat aca gtt ccg cct gtc ctc gtt 403 Ile Lys Phe Ser Gln Val Val Gly Tyr Thr Val Pro Pro Val Leu Val                  90 95 100 gtt atc gcc gtg atc tgc att tac ctg ttc ctg cga gca tca atc att 451 Val Ile Ala Val Ile Cys Ile Tyr Leu Phe Leu Arg Ala Ser Ile Ile             105 110 115 taaaaagatg cttctcg 468 <210> 506 <211> 117 <212> PRT <213> Corynebacterium glutamicum <400> 506 Val Ile Ser Gly Phe Phe Thr Ser Ile Ser Thr Ala Thr Thr Trp Pro   1 5 10 15 Val Ile Ala Phe Leu Tyr Ser Gly Leu Leu Asn Ile Ala Val Pro Ser              20 25 30 Gly Gly Ser Lys Phe Ile Ile Glu Ala Pro Tyr Ile Ile Pro Thr Pro          35 40 45 Val Asp Leu Gly Ala Asp Met Gly Leu Val Leu Gln Ala Tyr Gln Met      50 55 60 Ser Asp Gly Ala Thr Asn Leu Leu Ile Pro Phe Phe Ala Leu Pro Tyr  65 70 75 80 Leu Ala Asn Phe Lys Ile Lys Phe Ser Gln Val Val Gly Tyr Thr Val                  85 90 95 Pro Pro Val Leu Val Val Ile Ala Val Ile Cys Ile Tyr Leu Phe Leu             100 105 110 Arg Ala Ser Ile Ile         115 <210> 507 <211> 1329 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (101) .. (1306) <223> RXA01667 <400> 507 tctcggcgtt gatgatcatc cgcaatatca tgccgccgca agattccgct tttccagact 60 ttgctcattc cttcctctat tactgctcgc catcatcggc atg att ttg ggg cct 115                                             Met Ile Leu Gly Pro                                               1 5 aag gtg ttg ggt ctg att ggt tgg tcg gat cat ctt tcc act tac act 163 Lys Val Leu Gly Leu Ile Gly Trp Ser Asp His Leu Ser Thr Tyr Thr                  10 15 20 acg gtg ctc att gcg att gtg ttt gct tcg atg ccg tat tcg atg aag 211 Thr Val Leu Ile Ala Ile Val Phe Ala Ser Met Pro Tyr Ser Met Lys              25 30 35 ttt gac cgt ggc gtg cgt act ggc atg aag acg atg tgg gcg tat tcg 259 Phe Asp Arg Gly Val Arg Thr Gly Met Lys Thr Met Trp Ala Tyr Ser          40 45 50 act gcg atg ttt gtg ggg cag tgg ggt ctg ttc att ttg ctg ggt ctg 307 Thr Ala Met Phe Val Gly Gln Trp Gly Leu Phe Ile Leu Leu Gly Leu      55 60 65 ttt ttg ttc caa ccg gtg tgg ggt acc gat gag tgg ttc ggc atg atg 355 Phe Leu Phe Gln Pro Val Trp Gly Thr Asp Glu Trp Phe Gly Met Met  70 75 80 85 ttg ccg gtt ggt ttt gtt ggt ggt ttt ggt act gct gct gcg gtg ggt 403 Leu Pro Val Gly Phe Val Gly Gly Phe Gly Thr Ala Ala Ala Val Gly                  90 95 100 act gcg ttg gag tct tcg ggt gcg gag gct gcg atg tct ttg ggc ttt 451 Thr Ala Leu Glu Ser Ser Gly Ala Glu Ala Ala Met Ser Leu Gly Phe             105 110 115 acc tct gcg acg gtg ggt act ttt gct gcg att gtt ggt gga att att 499 Thr Ser Ala Thr Val Gly Thr Phe Ala Ala Ile Val Gly Gly Ile Ile         120 125 130 ttc aca acg tgg ggt att aag aag ggc aag act gcg gcg atg cct gcg 547 Phe Thr Thr Trp Gly Ile Lys Lys Gly Lys Thr Ala Ala Met Pro Ala     135 140 145 cag ttg ccg tgg gat ttg cgt tcg ggt tat atc gat aag ctg agt gat 595 Gln Leu Pro Trp Asp Leu Arg Ser Gly Tyr Ile Asp Lys Leu Ser Asp 150 155 160 165 cgt ccg tcg att ggt aag gcg agt acg aat ccg tct gcg att gag cct 643 Arg Pro Ser Ile Gly Lys Ala Ser Thr Asn Pro Ser Ala Ile Glu Pro                 170 175 180 ttg gcg ctg cat act ggc att att ttg ttg act gtt gcg gtt gcg tat 691 Leu Ala Leu His Thr Gly Ile Ile Leu Leu Thr Val Ala Val Ala Tyr             185 190 195 tcc att aat cag tgg ttg ggt agc atg ttc cca acc gtg cag att ccg 739 Ser Ile Asn Gln Trp Leu Gly Ser Met Phe Pro Thr Val Gln Ile Pro         200 205 210 ttg ttt gcg atg tca ttt gtg gtc ggc att gtg ggc atg gga att atg 787 Leu Phe Ala Met Ser Phe Val Val Gly Ile Val Gly Met Gly Ile Met     215 220 225 cgt ttg ttg aag aag cct gag tat ttg gat cgc gac acc gtg aat tcc 835 Arg Leu Leu Lys Lys Pro Glu Tyr Leu Asp Arg Asp Thr Val Asn Ser 230 235 240 245 gtg tcg ggc gcg gcg acg gat tac ctc att gcg ttt ggt att gcc tcg 883 Val Ser Gly Ala Ala Thr Asp Tyr Leu Ile Ala Phe Gly Ile Ala Ser                 250 255 260 att gct cct gct gcg att gct gat tac tgg gtt cct ctt gtg gtg ctg 931 Ile Ala Pro Ala Ala Ile Ala Asp Tyr Trp Val Pro Leu Val Val Leu             265 270 275 ttt gtt ttg ggc acc atc aac tgt tgt ttc ttc ttt ttc tgg gtt gcg 979 Phe Val Leu Gly Thr Ile Asn Cys Cys Phe Phe Phe Phe Trp Val Ala         280 285 290 cct cgt ttc ttt ggc gag aag tgg ctg gag cgc gcg atc ttc ggt tgg 1027 Pro Arg Phe Phe Gly Glu Lys Trp Leu Glu Arg Ala Ile Phe Gly Trp     295 300 305 ggt tgg gct act gcc gcg gtt gct acc ggt atc gcg ttg ctg aag atc 1075 Gly Trp Ala Thr Ala Ala Val Ala Thr Gly Ile Ala Leu Leu Lys Ile 310 315 320 325 gtg gat ccg aag ttg aag tcg gga gcg ctt aat gag tac ggc gtg gct 1123 Val Asp Pro Lys Leu Lys Ser Gly Ala Leu Asn Glu Tyr Gly Val Ala                 330 335 340 tat atc ggt ttt gct cca ttt gaa atc ggc atg acc atc atc gcg ccg 1171 Tyr Ile Gly Phe Ala Pro Phe Glu Ile Gly Met Thr Ile Ile Ala Pro             345 350 355 atc gcg gtg ctc gca ggc ttt acc atg ggg ttg ggt tgg gcg tcg ttg 1219 Ile Ala Val Leu Ala Gly Phe Thr Met Gly Leu Gly Trp Ala Ser Leu         360 365 370 att gtt gcg atc gtg att ttt ggc ctc gcg tgg ggt ctg aag tgg ttg 1267 Ile Val Ala Ile Val Ile Phe Gly Leu Ala Trp Gly Leu Lys Trp Leu     375 380 385 ccg gag cgc gga cat gtc cgc ggc gag ggt aag ccg caa taaaggttgg 1316 Pro Glu Arg Gly His Val Arg Gly Glu Gly Lys Pro Gln 390 395 400 aagcgccggg tct 1329 <210> 508 <211> 402 <212> PRT <213> Corynebacterium glutamicum <400> 508 Met Ile Leu Gly Pro Lys Val Leu Gly Leu Ile Gly Trp Ser Asp His   1 5 10 15 Leu Ser Thr Tyr Thr Thr Val Leu Ile Ala Ile Val Phe Ala Ser Met              20 25 30 Pro Tyr Ser Met Lys Phe Asp Arg Gly Val Arg Thr Gly Met Lys Thr          35 40 45 Met Trp Ala Tyr Ser Thr Ala Met Phe Val Gly Gln Trp Gly Leu Phe      50 55 60 Ile Leu Leu Gly Leu Phe Leu Phe Gln Pro Val Trp Gly Thr Asp Glu  65 70 75 80 Trp Phe Gly Met Met Leu Pro Val Gly Phe Val Gly Gly Phe Gly Thr                  85 90 95 Ala Ala Ala Val Gly Thr Ala Leu Glu Ser Ser Gly Ala Glu Ala Ala             100 105 110 Met Ser Leu Gly Phe Thr Ser Ala Thr Val Gly Thr Phe Ala Ala Ile         115 120 125 Val Gly Gly Ile Ile Phe Thr Thr Trp Gly Ile Lys Lys Gly Lys Thr     130 135 140 Ala Ala Met Pro Ala Gln Leu Pro Trp Asp Leu Arg Ser Gly Tyr Ile 145 150 155 160 Asp Lys Leu Ser Asp Arg Pro Ser Ile Gly Lys Ala Ser Thr Asn Pro                 165 170 175 Ser Ala Ile Glu Pro Leu Ala Leu His Thr Gly Ile Ile Leu Leu Thr             180 185 190 Val Ala Val Ala Tyr Ser Ile Asn Gln Trp Leu Gly Ser Met Phe Pro         195 200 205 Thr Val Gln Ile Pro Leu Phe Ala Met Ser Phe Val Val Gly Ile Val     210 215 220 Gly Met Gly Ile Met Arg Leu Leu Lys Lys Pro Glu Tyr Leu Asp Arg 225 230 235 240 Asp Thr Val Asn Ser Val Ser Gly Ala Ala Thr Asp Tyr Leu Ile Ala                 245 250 255 Phe Gly Ile Ala Ser Ile Ala Pro Ala Ala Ile Ala Asp Tyr Trp Val             260 265 270 Pro Leu Val Val Leu Phe Val Leu Gly Thr Ile Asn Cys Cys Phe Phe         275 280 285 Phe Phe Trp Val Ala Pro Arg Phe Phe Gly Glu Lys Trp Leu Glu Arg     290 295 300 Ala Ile Phe Gly Trp Gly Trp Ala Thr Ala Ala Val Ala Thr Gly Ile 305 310 315 320 Ala Leu Leu Lys Ile Val Asp Pro Lys Leu Lys Ser Gly Ala Leu Asn                 325 330 335 Glu Tyr Gly Val Ala Tyr Ile Gly Phe Ala Pro Phe Glu Ile Gly Met             340 345 350 Thr Ile Ile Ala Pro Ile Ala Val Leu Ala Gly Phe Thr Met Gly Leu         355 360 365 Gly Trp Ala Ser Leu Ile Val Ala Ile Val Ile Phe Gly Leu Ala Trp     370 375 380 Gly Leu Lys Trp Leu Pro Glu Arg Gly His Val Arg Gly Glu Gly Lys 385 390 395 400 Pro gln <210> 509 <211> 1776 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1753) <223> RXA02171 <400> 509 aaccacattc gtcattactt acatctatgt catgtttgcg aacaagaact tggagcctcg 60 tcaggctgct attcgccaga agatggaagg ttaatcagat atg aat tcc act att 115                                             Met Asn Ser Thr Ile                                               1 5 ctc ctt gca caa gac gct gtt tct gag ggc gtc ggt aat ccg att ctt 163 Leu Leu Ala Gln Asp Ala Val Ser Glu Gly Val Gly Asn Pro Ile Leu                  10 15 20 aac atc agt gtc ttc gtc gtc ttc att att gtg acg atg acc gtg gtg 211 Asn Ile Ser Val Phe Val Val Phe Ile Ile Val Thr Met Thr Val Val              25 30 35 ctt cgc gtg ggc aag agc acc agc gaa tcc acc gac ttc tac acc ggt 259 Leu Arg Val Gly Lys Ser Thr Ser Glu Ser Thr Asp Phe Tyr Thr Gly          40 45 50 ggt gct tcc ttc tcc gga acc cag aac ggt ctg gct atc gca ggt gac 307 Gly Ala Ser Phe Ser Gly Thr Gln Asn Gly Leu Ala Ile Ala Gly Asp      55 60 65 tac ctg tct gca gcg tcc ttc ctc gga atc gtt ggt gca att tca ctc 355 Tyr Leu Ser Ala Ala Ser Phe Leu Gly Ile Val Gly Ala Ile Ser Leu  70 75 80 85 aac ggt tac gac gga ttc ctt tac tcc atc ggc ttc ttc gtc gca tgg 403 Asn Gly Tyr Asp Gly Phe Leu Tyr Ser Ile Gly Phe Phe Val Ala Trp                  90 95 100 ctt gtt gca ctg ctg ctc gtg gca gag cca ctt cgt aac gtg ggc cgc 451 Leu Val Ala Leu Leu Leu Val Ala Glu Pro Leu Arg Asn Val Gly Arg             105 110 115 ttc acc atg gct gac gtg ctg tcc ttc cga ctg cgt cag aaa cca gtc 499 Phe Thr Met Ala Asp Val Leu Ser Phe Arg Leu Arg Gln Lys Pro Val         120 125 130 cgc gtc gct gcg gcc tgc ggt acc ctc gcg gtt acc ctc ttt tac ttg 547 Arg Val Ala Ala Ala Cys Gly Thr Leu Ala Val Thr Leu Phe Tyr Leu     135 140 145 atc gct cag atg gct ggt gca ggt tcg ctt gtg tcc gtt ctg ctg gac 595 Ile Ala Gln Met Ala Gly Ala Gly Ser Leu Val Ser Val Leu Leu Asp 150 155 160 165 atc cac gag ttc aag tgg cag gca gtt gtt gtc ggt atc gtt ggc att 643 Ile His Glu Phe Lys Trp Gln Ala Val Val Val Gly Ile Val Gly Ile                 170 175 180 gtc atg atc gcc tac gtt ctt ctt ggc ggt atg aag ggc acc aca tac 691 Val Met Ile Ala Tyr Val Leu Leu Gly Gly Met Lys Gly Thr Thr Tyr             185 190 195 gtt cag atg att aag gca gtt ctg ctg gtc ggt ggc gtt gcc att atg 739 Val Gln Met Ile Lys Ala Val Leu Leu Val Gly Gly Val Ala Ile Met         200 205 210 acc gtt ctg acc ttc gtc aag gtg tct ggt ggc ctg acc acc ctt tta 787 Thr Val Leu Thr Phe Val Lys Val Ser Gly Gly Leu Thr Thr Leu Leu     215 220 225 aat gac gct gtt gag aag cac gcc gct tca gat tac gct gcc acc aag 835 Asn Asp Ala Val Glu Lys His Ala Ala Ser Asp Tyr Ala Ala Thr Lys 230 235 240 245 ggg tac gat cca acc cag atc ctg gag cct ggt ctg cag tac ggt gca 883 Gly Tyr Asp Pro Thr Gln Ile Leu Glu Pro Gly Leu Gln Tyr Gly Ala                 250 255 260 act ctg acc act cag ctg gac ttc att tcc ttg gct ctc gct ctg tgt 931 Thr Leu Thr Thr Gln Leu Asp Phe Ile Ser Leu Ala Leu Ala Leu Cys             265 270 275 ctt gga acc gct ggt ctg cca cac gtt ctg atg cgc ttc tac acc gtt 979 Leu Gly Thr Ala Gly Leu Pro His Val Leu Met Arg Phe Tyr Thr Val         280 285 290 cct acc gcc aag gaa gca cgt aag tct gtg acc tgg gct atc gtc ctc 1027 Pro Thr Ala Lys Glu Ala Arg Lys Ser Val Thr Trp Ala Ile Val Leu     295 300 305 att ggt gcg ttc tac ctg atg acc ctg gtc ctt ggt tac ggc gct gcg 1075 Ile Gly Ala Phe Tyr Leu Met Thr Leu Val Leu Gly Tyr Gly Ala Ala 310 315 320 325 gca ctg gtc ggt cca gac cgc gtc att gcc gca cca ggt gct gct aat 1123 Ala Leu Val Gly Pro Asp Arg Val Ile Ala Ala Pro Gly Ala Ala Asn                 330 335 340 gct gct gct cct ctg ctg gcc ttc gag ctt ggt ggt tcc atc ttc atg 1171 Ala Ala Ala Pro Leu Leu Ala Phe Glu Leu Gly Gly Ser Ile Phe Met             345 350 355 gcg ctg att tcc gca gtt gcg ttc gct acc gtt ctc gcc gtg gtc gca 1219 Ala Leu Ile Ser Ala Val Ala Phe Ala Thr Val Leu Ala Val Val Ala         360 365 370 ggt ctt gca att acc gca tcc gct gct gtt ggt cac gac atc tac aac 1267 Gly Leu Ala Ile Thr Ala Ser Ala Ala Val Gly His Asp Ile Tyr Asn     375 380 385 gct gtt atc cgc aac ggt cag tcc acc gaa gcg gag cag gtc cga gta 1315 Ala Val Ile Arg Asn Gly Gln Ser Thr Glu Ala Glu Gln Val Arg Val 390 395 400 405 tcc cgc atc acc gtt gtc gtc att ggc ctg att tcc att gtc ctg gga 1363 Ser Arg Ile Thr Val Val Val Ile Gly Leu Ile Ser Ile Val Leu Gly                 410 415 420 att ctt gca atg acc cag aac gtt gcg ttc ctc gtg gcc ctg gcc ttc 1411 Ile Leu Ala Met Thr Gln Asn Val Ala Phe Leu Val Ala Leu Ala Phe             425 430 435 gca gtt gca gca tcc gct aac ctg cca acc atc ctg tac tcc ctg tac 1459 Ala Val Ala Ala Ser Ala Asn Leu Pro Thr Ile Leu Tyr Ser Leu Tyr         440 445 450 tgg aag aag ttc aac acc acc ggc gct gtg gcc gct atc tac acc ggt 1507 Trp Lys Lys Phe Asn Thr Thr Gly Ala Val Ala Ala Ile Tyr Thr Gly     455 460 465 ctc atc tcc gcg ctg ctg ctg atc ttc ctg tcc cca gca gtc tcc ggt 1555 Leu Ile Ser Ala Leu Leu Leu Ile Phe Leu Ser Pro Ala Val Ser Gly 470 475 480 485 aat gac agc gca atg gtt cca ggt gca gac tgg gca atc ttc cca ctg 1603 Asn Asp Ser Ala Met Val Pro Gly Ala Asp Trp Ala Ile Phe Pro Leu                 490 495 500 aag aac cca ggc ctc gtc tcc atc cca ctg gca ttc atc gct ggt tgg 1651 Lys Asn Pro Gly Leu Val Ser Ile Pro Leu Ala Phe Ile Ala Gly Trp             505 510 515 atc ggc act ttg gtt ggc aag cca gac aac atg gat gat ctt gct gcc 1699 Ile Gly Thr Leu Val Gly Lys Pro Asp Asn Met Asp Asp Leu Ala Ala         520 525 530 gaa atg gaa gtt cgt tcc ctc acc ggt gtc ggt gtt gaa aag gct gtt 1747 Glu Met Glu Val Arg Ser Leu Thr Gly Val Gly Val Glu Lys Ala Val     535 540 545 gat cac taaatctagt ttctgaagtt att 1776 Asp his 550 <210> 510 <211> 551 <212> PRT <213> Corynebacterium glutamicum <400> 510 Met Asn Ser Thr Ile Leu Leu Ala Gln Asp Ala Val Ser Glu Gly Val   1 5 10 15 Gly Asn Pro Ile Leu Asn Ile Ser Val Phe Val Val Phe Ile Ile Val              20 25 30 Thr Met Thr Val Val Leu Arg Val Gly Lys Ser Thr Ser Glu Ser Thr          35 40 45 Asp Phe Tyr Thr Gly Gly Ala Ser Phe Ser Gly Thr Gln Asn Gly Leu      50 55 60 Ala Ile Ala Gly Asp Tyr Leu Ser Ala Ala Ser Phe Leu Gly Ile Val  65 70 75 80 Gly Ala Ile Ser Leu Asn Gly Tyr Asp Gly Phe Leu Tyr Ser Ile Gly                  85 90 95 Phe Phe Val Ala Trp Leu Val Ala Leu Leu Leu Val Ala Glu Pro Leu             100 105 110 Arg Asn Val Gly Arg Phe Thr Met Ala Asp Val Leu Ser Phe Arg Leu         115 120 125 Arg Gln Lys Pro Val Arg Val Ala Ala Ala Cys Gly Thr Leu Ala Val     130 135 140 Thr Leu Phe Tyr Leu Ile Ala Gln Met Ala Gly Ala Gly Ser Leu Val 145 150 155 160 Ser Val Leu Leu Asp Ile His Glu Phe Lys Trp Gln Ala Val Val Val                 165 170 175 Gly Ile Val Gly Ile Val Met Ile Ala Tyr Val Leu Leu Gly Gly Met             180 185 190 Lys Gly Thr Thr Tyr Val Gln Met Ile Lys Ala Val Leu Leu Val Gly         195 200 205 Gly Val Ala Ile Met Thr Val Leu Thr Phe Val Lys Val Ser Gly Gly     210 215 220 Leu Thr Thr Leu Leu Asn Asp Ala Val Glu Lys His Ala Ala Ser Asp 225 230 235 240 Tyr Ala Ala Thr Lys Gly Tyr Asp Pro Thr Gln Ile Leu Glu Pro Gly                 245 250 255 Leu Gln Tyr Gly Ala Thr Leu Thr Thr Gln Leu Asp Phe Ile Ser Leu             260 265 270 Ala Leu Ala Leu Cys Leu Gly Thr Ala Gly Leu Pro His Val Leu Met         275 280 285 Arg Phe Tyr Thr Val Pro Thr Ala Lys Glu Ala Arg Lys Ser Val Thr     290 295 300 Trp Ala Ile Val Leu Ile Gly Ala Phe Tyr Leu Met Thr Leu Val Leu 305 310 315 320 Gly Tyr Gly Ala Ala Ala Leu Val Gly Pro Asp Arg Val Ile Ala Ala                 325 330 335 Pro Gly Ala Ala Asn Ala Ala Ala Pro Leu Leu Ala Phe Glu Leu Gly             340 345 350 Gly Ser Ile Phe Met Ala Leu Ile Ser Ala Val Ala Phe Ala Thr Val         355 360 365 Leu Ala Val Val Ala Gly Leu Ala Ile Thr Ala Ser Ala Ala Val Gly     370 375 380 His Asp Ile Tyr Asn Ala Val Ile Arg Asn Gly Gln Ser Thr Glu Ala 385 390 395 400 Glu Gln Val Arg Val Ser Arg Ile Thr Val Val Val Ile Gly Leu Ile                 405 410 415 Ser Ile Val Leu Gly Ile Leu Ala Met Thr Gln Asn Val Ala Phe Leu             420 425 430 Val Ala Leu Ala Phe Ala Val Ala Ala Ser Ala Asn Leu Pro Thr Ile         435 440 445 Leu Tyr Ser Leu Tyr Trp Lys Lys Phe Asn Thr Thr Gly Ala Val Ala     450 455 460 Ala Ile Tyr Thr Gly Leu Ile Ser Ala Leu Leu Leu Ile Phe Leu Ser 465 470 475 480 Pro Ala Val Ser Gly Asn Asp Ser Ala Met Val Pro Gly Ala Asp Trp                 485 490 495 Ala Ile Phe Pro Leu Lys Asn Pro Gly Leu Val Ser Ile Pro Leu Ala             500 505 510 Phe Ile Ala Gly Trp Ile Gly Thr Leu Val Gly Lys Pro Asp Asn Met         515 520 525 Asp Asp Leu Ala Ala Glu Met Glu Val Arg Ser Leu Thr Gly Val Gly     530 535 540 Val Glu Lys Ala Val Asp His 545 550 <210> 511 <211> 1333 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (1333) <223> RXA00902 <400> 511 ttgttattgg tttgttcact cccatgcaat gtacgatcgg ttctaacgtc tacggcaatt 60 gacacgtcaa tttaattcag gaaaggggtg gggagaattt atg tct agt ggt ttt 115                                             Met Ser Ser Gly Phe                                               1 5 gaa tat gtt caa cat cct cga cga gcc ctc cct ccg cct ata cct gaa 163 Glu Tyr Val Gln His Pro Arg Arg Ala Leu Pro Pro Pro Ile Pro Glu                  10 15 20 cgg aaa ggt cct gcc gca gca ttc ctg ccg gga act ttc cat ccc att 211 Arg Lys Gly Pro Ala Ala Ala Phe Leu Pro Gly Thr Phe His Pro Ile              25 30 35 aat cca aag aat att gca gcg agc cac gat cag gtg ctt cta tct ggt 259 Asn Pro Lys Asn Ile Ala Ala Ser His Asp Gln Val Leu Leu Ser Gly          40 45 50 tgg ggc aaa ttt gtg cgt tgg ctc ttg gta ttg ttg tcc att ttg gtc 307 Trp Gly Lys Phe Val Arg Trp Leu Leu Val Leu Leu Ser Ile Leu Val      55 60 65 atc atc att ggc atc aac ctc atc ttg gac ggt gtc tac gga ttt ggt 355 Ile Ile Ile Gly Ile Asn Leu Ile Leu Asp Gly Val Tyr Gly Phe Gly  70 75 80 85 act ttt tca acc acc cag atg tac caa gtt gcg aaa gat cca ctc att 403 Thr Phe Ser Thr Thr Gln Met Tyr Gln Val Ala Lys Asp Pro Leu Ile                  90 95 100 ggt gtg ctg atc ggt atc ttg gct acg gcc ttg gtg caa tca tca acc 451 Gly Val Leu Ile Gly Ile Leu Ala Thr Ala Leu Val Gln Ser Ser Thr             105 110 115 acc acc aca acg ttg acg gtg act gca gtt ggt acg ggc att gtg tcg 499 Thr Thr Thr Thr Le Leu Thr Val Thr Ala Val Gly Thr Gly Ile Val Ser         120 125 130 gtg cct gtg gcg att ccg atc att ctt ggc gca aat atc ggt acg acg 547 Val Pro Val Ala Ile Pro Ile Ile Leu Gly Ala Asn Ile Gly Thr Thr     135 140 145 atc acc gcg atg ctc gtt gcg ttt tct tat gtg ggt gaa cgc agg gag 595 Ile Thr Ala Met Leu Val Ala Phe Ser Tyr Val Gly Glu Arg Arg Glu 150 155 160 165 ttt aag cga gct ttt acg gtt gcc gcc atg cat gtg tgg ttt aac gtg 643 Phe Lys Arg Ala Phe Thr Val Ala Ala Met His Val Trp Phe Asn Val                 170 175 180 ctc gtc att ctt gtt cta ttt gtt gtg gaa ttg ctc ttt cat cca ttc 691 Leu Val Ile Leu Val Leu Phe Val Val Glu Leu Leu Phe His Pro Phe             185 190 195 cgc aca att agt ggt gcg atc gca acg gag atc aca ctg aca act ggt 739 Arg Thr Ile Ser Gly Ala Ile Ala Thr Glu Ile Thr Leu Thr Thr Gly         200 205 210 ggc tct ttg cct acc agt ggt gtg atg acc aag att ttt gat ccc cca 787 Gly Ser Leu Pro Thr Ser Gly Val Met Thr Lys Ile Phe Asp Pro Pro     215 220 225 acc caa ctt ctg ggt atg aat ggt ctt atc ggt tcg atc ggc aat cct 835 Thr Gln Leu Leu Gly Met Asn Gly Leu Ile Gly Ser Ile Gly Asn Pro 230 235 240 245 agt att tcg gcg att gta tgt ctt gtg gtg ggc acc att ctt att ctg 883 Ser Ile Ser Ala Ile Val Cys Leu Val Val Gly Thr Ile Leu Ile Leu                 250 255 260 att tcg gtg cgt gcc atg agt tct cag atc cga acc att acg gca gcg 931 Ile Ser Val Arg Ala Met Ser Ser Gln Ile Arg Thr Ile Thr Ala Ala             265 270 275 acc gta acc tca att atg gac aag gtg atc aat cca gag aac agc ccc 979 Thr Val Thr Ser Ile Met Asp Lys Val Ile Asn Pro Glu Asn Ser Pro         280 285 290 aag gcg acg att ctt tcc aat ttc tgg agc ttc att ctt gga gtt ttg 1027 Lys Ala Thr Ile Leu Ser Asn Phe Trp Ser Phe Ile Leu Gly Val Leu     295 300 305 ttc acg ctc atg gtc act gcc tcg tca gtg acc gtg gct tcc atg cag 1075 Phe Thr Leu Met Val Thr Ala Ser Ser Val Thr Val Ala Ser Met Gln 310 315 320 325 cca gtg gct gcc tct ggt gtc gtt aag caa aag cca ttg ctg ggc gtc 1123 Pro Val Ala Ala Ser Gly Val Val Lys Gln Lys Pro Leu Leu Gly Val                 330 335 340 att ttg ggt gcc aac gtg ggc acc acg gtg acc gca atg ttt gct act 1171 Ile Leu Gly Ala Asn Val Gly Thr Thr Val Val Ala Met Phe Ala Thr             345 350 355 ttc gcg att gtc agc gat cag ggt gag ttc gct att cag gct gcg ttg 1219 Phe Ala Ile Val Ser Asp Gln Gly Glu Phe Ala Ile Gln Ala Ala Leu         360 365 370 atc cac ctc att gtg aac ttc acc ggc gca tta cta gtg ctg tgt att 1267 Ile His Leu Ile Val Asn Phe Thr Gly Ala Leu Leu Val Leu Cys Ile     375 380 385 ccg cag ctt gcc aat gtg att att cac ttg gcc gag aaa act gcg aac 1315 Pro Gln Leu Ala Asn Val Ile Ile His Leu Ala Glu Lys Thr Ala Asn 390 395 400 405 ctc act gcc cgc agt tac 1333 Leu Thr Ala Arg Ser Tyr                 410 <210> 512 <211> 411 <212> PRT <213> Corynebacterium glutamicum <400> 512 Met Ser Ser Gly Phe Glu Tyr Val Gln His Pro Arg Arg Ala Leu Pro   1 5 10 15 Pro Pro Ile Pro Glu Arg Lys Gly Pro Ala Ala Ala Phe Leu Pro Gly              20 25 30 Thr Phe His Pro Ile Asn Pro Lys Asn Ile Ala Ala Ser His Asp Gln          35 40 45 Val Leu Leu Ser Gly Trp Gly Lys Phe Val Arg Trp Leu Leu Val Leu      50 55 60 Leu Ser Ile Leu Val Ile Ile Ile Gly Ile Asn Leu Ile Leu Asp Gly  65 70 75 80 Val Tyr Gly Phe Gly Thr Phe Ser Thr Thr Gln Met Tyr Gln Val Ala                  85 90 95 Lys Asp Pro Leu Ile Gly Val Leu Ile Gly Ile Leu Ala Thr Ala Leu             100 105 110 Val Gln Ser Ser Thr Thr Thr Thr Thr Leu Thr Val Thr Ala Val Gly         115 120 125 Thr Gly Ile Val Ser Val Pro Val Ala Ile Pro Ile Ile Leu Gly Ala     130 135 140 Asn Ile Gly Thr Thr Ile Thr Ala Met Leu Val Ala Phe Ser Tyr Val 145 150 155 160 Gly Glu Arg Arg Glu Phe Lys Arg Ala Phe Thr Val Ala Ala Met His                 165 170 175 Val Trp Phe Asn Val Leu Val Ile Leu Val Leu Phe Val Val Glu Leu             180 185 190 Leu Phe His Pro Phe Arg Thr Ile Ser Gly Ala Ile Ala Thr Glu Ile         195 200 205 Thr Leu Thr Thr Gly Gly Ser Leu Pro Thr Ser Gly Val Met Thr Lys     210 215 220 Ile Phe Asp Pro Pro Thr Gln Leu Leu Gly Met Asn Gly Leu Ile Gly 225 230 235 240 Ser Ile Gly Asn Pro Ser Ile Ser Ala Ile Val Cys Leu Val Val Gly                 245 250 255 Thr Ile Leu Ile Leu Ile Ser Val Arg Ala Met Ser Ser Gln Ile Arg             260 265 270 Thr Ile Thr Ala Ala Thr Val Thr Ser Ser Ile Met Asp Lys Val Ile Asn         275 280 285 Pro Glu Asn Ser Pro Lys Ala Thr Ile Leu Ser Asn Phe Trp Ser Phe     290 295 300 Ile Leu Gly Val Leu Phe Thr Leu Met Val Thr Ala Ser Ser Val Thr 305 310 315 320 Val Ala Ser Met Gln Pro Val Ala Ala Ser Gly Val Val Lys Gln Lys                 325 330 335 Pro Leu Leu Gly Val Ile Leu Gly Ala Asn Val Gly Thr Thr Val Thr             340 345 350 Ala Met Phe Ala Thr Phe Ala Ile Val Ser Asp Gln Gly Glu Phe Ala         355 360 365 Ile Gln Ala Ala Leu Ile His Leu Ile Val Asn Phe Thr Gly Ala Leu     370 375 380 Leu Val Leu Cys Ile Pro Gln Leu Ala Asn Val Ile Ile His Leu Ala 385 390 395 400 Glu Lys Thr Ala Asn Leu Thr Ala Arg Ser Tyr                 405 410 <210> 513 <211> 1440 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (1417) <223> RXA00941 <400> 513 agccggggtg gccgtttgcg tgtacgggtt ttgcttatcg acgcccactt ctgattttaa 60 aggcaaatat tttgtgtcac agcgagtaat cttttcgggc atg aac cta acc cgg 115                                             Met Asn Leu Thr Arg                                               1 5 aat gac agg ctc gat cga ctg ccc gta act tcc aaa cat aaa aag att 163 Asn Asp Arg Leu Asp Arg Leu Pro Val Thr Ser Lys His Lys Lys Ile                  10 15 20 ctt ggc ggc tca ggt atc ggc tgg gca ttg gat gcc atg gat gtc gga 211 Leu Gly Gly Ser Gly Ile Gly Trp Ala Leu Asp Ala Met Asp Val Gly              25 30 35 ctg atc tct ttc gtc atg gct gcg ttg gcc act cat tgg ggc cta tcc 259 Leu Ile Ser Phe Val Met Ala Ala Leu Ala Thr His Trp Gly Leu Ser          40 45 50 cct act gaa act tcc ctg ctc gga tcc atc ggt ttc gtt ggc atg gcc 307 Pro Thr Glu Thr Ser Leu Leu Gly Ser Ile Gly Phe Val Gly Met Ala      55 60 65 atc ggc gct tcg ctg ggc ggt ttg ctg gcg gac aag ttg ggg cgt cga 355 Ile Gly Ala Ser Leu Gly Gly Leu Leu Ala Asp Lys Leu Gly Arg Arg  70 75 80 85 caa gtt ttt gcg ttg tct ttg cta gtt tat ggc gtt gcc act ggc gcg 403 Gln Val Phe Ala Leu Ser Leu Leu Val Tyr Gly Val Ala Thr Gly Ala                  90 95 100 tcg gcg ctt tca gtg tcg ctg gca atg ttg atg gcg ctg cgc ttc gtc 451 Ser Ala Leu Ser Val Ser Leu Ala Met Leu Met Ala Leu Arg Phe Val             105 110 115 gtt gga ctt ggc ctg ggc gct gaa ctc ccc gtt gca tcc act ctg att 499 Val Gly Leu Gly Leu Gly Ala Glu Leu Pro Val Ala Ser Thr Leu Ile         120 125 130 tcc gag ttt tct cca cga aaa gtt cgt ggc cgc atg gtc gtt atc ctg 547 Ser Glu Phe Ser Pro Arg Lys Val Arg Gly Arg Met Val Val Ile Leu     135 140 145 gag gcg ttt tgg gcg ctg ggc tgg atc atg gct gca atc gtc gga acc 595 Glu Ala Phe Trp Ala Leu Gly Trp Ile Met Ala Ala Ile Val Gly Thr 150 155 160 165 ttt gtc gtg gca gga tcc gat aat ggt tgg cgt tgg gcg tta gct ctt 643 Phe Val Val Ala Gly Ser Asp Asn Gly Trp Arg Trp Ala Leu Ala Leu                 170 175 180 ggc tgt gtc cct gca att tac gcg gtg tat gtc cgt ctc gga ctt cca 691 Gly Cys Val Pro Ala Ile Tyr Ala Val Tyr Val Arg Leu Gly Leu Pro             185 190 195 gaa tca gta cgt ttc ctg gag aag aaa ggc cgg cac gac gaa gca gaa 739 Glu Ser Val Arg Phe Leu Glu Lys Lys Gly Arg His Asp Glu Ala Glu         200 205 210 gcc atc gtt gtt tcc ttc gaa gaa gct gcc gct gcc gaa ggt aaa gct 787 Ala Ile Val Val Ser Phe Glu Glu Ala Ala Ala Ala Glu Gly Lys Ala     215 220 225 gcc gat gcc acc acc gct gtg gtt cat gac aac gct gcc gag ggt tcc 835 Ala Asp Ala Thr Thr Ala Val Val His Asp Asn Ala Ala Glu Gly Ser 230 235 240 245 gta tcc atc tgg tca gct gct ttg cgc aag cgc acc gtc gcg ctg tgg 883 Val Ser Ile Trp Ser Ala Ala Leu Arg Lys Arg Thr Val Ala Leu Trp                 250 255 260 atc gtg tgg ttc tgc atc aac ttg tcc tac tac gga gcc ttc att tgg 931 Ile Val Trp Phe Cys Ile Asn Leu Ser Tyr Tyr Gly Ala Phe Ile Trp             265 270 275 att cca tcg ctg ctg gtt gcc gac ggt ttc acc ctc gtg aag tct ttc 979 Ile Pro Ser Leu Leu Val Ala Asp Gly Phe Thr Leu Val Lys Ser Phe         280 285 290 caa ttc act ctg atc atc acc ttg gct cag ctt cca ggc tat gcg gtt 1027 Gln Phe Thr Leu Ile Ile Thr Leu Ala Gln Leu Pro Gly Tyr Ala Val     295 300 305 gca gcg tgg ttg att gaa aag tgg ggc cgt cgc agc aca ttg gcc acg 1075 Ala Ala Trp Leu Ile Glu Lys Trp Gly Arg Arg Ser Thr Leu Ala Thr 310 315 320 325 ttc ctg gtt ggt tct gct atc tct gca gcg ctc tac ggc ttg gca aat 1123 Phe Leu Val Gly Ser Ala Ile Ser Ala Ala Leu Tyr Gly Leu Ala Asn                 330 335 340 gtg gag tgg cag atc ctg gtc gca ggt tgt tta cta tcc ttc ttc aac 1171 Val Glu Trp Gln Ile Leu Val Ala Gly Cys Leu Leu Ser Phe Phe Asn             345 350 355 ctg ggc gca tgg ggc gca ctg tat gcc att ggg ccg gag ctt tat ccc 1219 Leu Gly Ala Trp Gly Ala Leu Tyr Ala Ile Gly Pro Glu Leu Tyr Pro         360 365 370 act aat gtc cgt gga act gga acg ggt gct gcc gcg gga ttc ggg cgc 1267 Thr Asn Val Arg Gly Thr Gly Thr Gly Ala Ala Ala Gly Phe Gly Arg     375 380 385 att gct tcc atc atc gct ccg ctc att gtt ccg cca gtg att gct ttt 1315 Ile Ala Ser Ile Ile Ala Pro Leu Ile Val Pro Pro Val Ile Ala Phe 390 395 400 405 ggt gga cca att gct ttg ttc gct ctc ttt gcc acc gcg ttt gcg atc 1363 Gly Gly Pro Ile Ala Leu Phe Ala Leu Phe Ala Thr Ala Phe Ala Ile                 410 415 420 gca gcg att gcg gcg ttt acg ctg cct gag cag aag ggt aag tct ctc 1411 Ala Ala Ile Ala Ala Phe Thr Leu Pro Glu Gln Lys Gly Lys Ser Leu             425 430 435 gct gat tagtgagatc cttccaccag ttt 1440 Ala asp <210> 514 <211> 439 <212> PRT <213> Corynebacterium glutamicum <400> 514 Met Asn Leu Thr Arg Asn Asp Arg Leu Asp Arg Leu Pro Val Thr Ser   1 5 10 15 Lys His Lys Lys Ile Leu Gly Gly Ser Gly Ile Gly Trp Ala Leu Asp              20 25 30 Ala Met Asp Val Gly Leu Ile Ser Phe Val Met Ala Ala Leu Ala Thr          35 40 45 His Trp Gly Leu Ser Pro Thr Glu Thr Ser Leu Leu Gly Ser Ile Gly      50 55 60 Phe Val Gly Met Ala Ile Gly Ala Ser Leu Gly Gly Leu Leu Ala Asp  65 70 75 80 Lys Leu Gly Arg Arg Gln Val Phe Ala Leu Ser Leu Leu Val Tyr Gly                  85 90 95 Val Ala Thr Gly Ala Ser Ala Leu Ser Val Ser Leu Ala Met Leu Met             100 105 110 Ala Leu Arg Phe Val Val Gly Leu Gly Leu Gly Ala Glu Leu Pro Val         115 120 125 Ala Ser Thr Leu Ile Ser Glu Phe Ser Pro Arg Lys Val Arg Gly Arg     130 135 140 Met Val Val Ile Leu Glu Ala Phe Trp Ala Leu Gly Trp Ile Met Ala 145 150 155 160 Ala Ile Val Gly Thr Phe Val Val Ala Gly Ser Asp Asn Gly Trp Arg                 165 170 175 Trp Ala Leu Ala Leu Gly Cys Val Pro Ala Ile Tyr Ala Val Tyr Val             180 185 190 Arg Leu Gly Leu Pro Glu Ser Val Arg Phe Leu Glu Lys Lys Gly Arg         195 200 205 His Asp Glu Ala Glu Ala Ile Val Val Ser Phe Glu Glu Ala Ala Ala     210 215 220 Ala Glu Gly Lys Ala Ala Asp Ala Thr Thr Ala Val Val His Asp Asn 225 230 235 240 Ala Ala Glu Gly Ser Val Ser Ile Trp Ser Ala Ala Leu Arg Lys Arg                 245 250 255 Thr Val Ala Leu Trp Ile Val Trp Phe Cys Ile Asn Leu Ser Tyr Tyr             260 265 270 Gly Ala Phe Ile Trp Ile Pro Ser Leu Leu Val Ala Asp Gly Phe Thr         275 280 285 Leu Val Lys Ser Phe Gln Phe Thr Leu Ile Ile Thr Leu Ala Gln Leu     290 295 300 Pro Gly Tyr Ala Val Ala Ala Trp Leu Ile Glu Lys Trp Gly Arg Arg 305 310 315 320 Ser Thr Leu Ala Thr Phe Leu Val Gly Ser Ala Ile Ser Ala Ala Leu                 325 330 335 Tyr Gly Leu Ala Asn Val Glu Trp Gln Ile Leu Val Ala Gly Cys Leu             340 345 350 Leu Ser Phe Phe Asn Leu Gly Ala Trp Gly Ala Leu Tyr Ala Ile Gly         355 360 365 Pro Glu Leu Tyr Pro Thr Asn Val Arg Gly Thr Gly Thr Gly Ala Ala     370 375 380 Ala Gly Phe Gly Arg Ile Ala Ser Ile Ile Ala Pro Leu Ile Val Pro 385 390 395 400 Pro Val Ile Ala Phe Gly Gly Pro Ile Ala Leu Phe Ala Leu Phe Ala                 405 410 415 Thr Ala Phe Ala Ile Ala Ala Ile Ala Ala Phe Thr Leu Pro Glu Gln             420 425 430 Lys Gly Lys Ser Leu Ala Asp         435 <210> 515 <211> 1704 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (1681) <223> RXN00449 <400> 515 tcgttggctt acatggtcat tgatgaccgg gctgaatatg tgagaaaatc catcccttct 60 ttaagcaagg gagtgaatta cagaaaagga ttgttcagca atg agc aca cct gac 115                                             Met Ser Thr Pro Asp                                               1 5 att aaa gaa ggc tcg gca gaa tca ccg ggc gaa gta atg gtc gtt gga 163 Ile Lys Glu Gly Ser Ala Glu Ser Pro Gly Glu Val Met Val Val Gly                  10 15 20 gac agg cga gag tgg cgt cga caa gca acc ggc atc att gcc ggc ctc 211 Asp Arg Arg Glu Trp Arg Arg Gln Ala Thr Gly Ile Ile Ala Gly Leu              25 30 35 gtc tta gcc gcc ctg gtc tat ctt ctc ttc ccc tcg aac tcc gtg gaa 259 Val Leu Ala Ala Leu Val Tyr Leu Leu Phe Pro Ser Asn Ser Val Glu          40 45 50 acc gtc atg caa tcc agt ggc gtc gat cca gaa act gaa tac acc aac 307 Thr Val Met Gln Ser Ser Gly Val Asp Pro Glu Thr Glu Tyr Thr Asn      55 60 65 aac gcg atg cgt ctt act gct gca gtc aca atc ttg atg gca gtg tgg 355 Asn Ala Met Arg Leu Thr Ala Ala Val Thr Ile Leu Met Ala Val Trp  70 75 80 85 tgg atg aca gaa gca atc cca cta gca gca acc gca ctt atc ccg ttg 403 Trp Met Thr Glu Ala Ile Pro Leu Ala Ala Thr Ala Leu Ile Pro Leu                  90 95 100 gtt gca ttc cct gct ttc cag gtt gtg gac ttt ggg aag gca aca gct 451 Val Ala Phe Pro Ala Phe Gln Val Val Asp Phe Gly Lys Ala Thr Ala             105 110 115 ccg tat gcc aac cct acg agc ttc ctc ttc ttg ggc ggc ttt ctt atg 499 Pro Tyr Ala Asn Pro Thr Ser Phe Leu Phe Leu Gly Gly Phe Leu Met         120 125 130 gca ctt ggc ctg cag aaa tgg aac cta cac cga cgt atg gct cta gcg 547 Ala Leu Gly Leu Gln Lys Trp Asn Leu His Arg Arg Met Ala Leu Ala     135 140 145 gtc gtg cta gct gtt ggt act aag cca aag caa ttg gtc ttg ggt ttt 595 Val Val Leu Ala Val Gly Thr Lys Pro Lys Gln Leu Val Leu Gly Phe 150 155 160 165 atg gtg gca act gga ttt ttg tcc atg tgg gtg tct aac act gca acg 643 Met Val Ala Thr Gly Phe Leu Ser Met Trp Val Ser Asn Thr Ala Thr                 170 175 180 gcc gtg gtt atg tta ccg atc ggt atg tcg gta ctg gca ctg acc gct 691 Ala Val Val Met Leu Pro Ile Gly Met Ser Val Leu Ala Leu Thr Ala             185 190 195 gag act gtg ggc gga atg aaa aac caa aag aaa ttc gcc act gga ctc 739 Glu Thr Val Gly Gly Met Lys Asn Gln Lys Lys Phe Ala Thr Gly Leu         200 205 210 atg ctg tcc att gct tat tct gct tcc atc ggt tca ctc ggc acc tta 787 Met Leu Ser Ile Ala Tyr Ser Ala Ser Ile Gly Ser Leu Gly Thr Leu     215 220 225 att ggc acg cca ccc aat gcc ttg ctt gct gcg tat atg tct gaa tcg 835 Ile Gly Thr Pro Pro Asn Ala Leu Leu Ala Ala Tyr Met Ser Glu Ser 230 235 240 245 cat gat atc cac atc gga ttt ggt cag tgg atg att ctt ggt gta cca 883 His Asp Ile His Ile Gly Phe Gly Gln Trp Met Ile Leu Gly Val Pro                 250 255 260 att gct gtc gtc ttc acc atc atc gcg tgg ctt gtg ttg acc acc gtg 931 Ile Ala Val Val Phe Thr Ile Ile Ala Trp Leu Val Leu Thr Thr Val             265 270 275 ttc aag cca gaa atg aaa gaa atc cct ggc gga cgt gaa ctg atc aaa 979 Phe Lys Pro Glu Met Lys Glu Ile Pro Gly Gly Arg Glu Leu Ile Lys         280 285 290 cgt gaa atc gct gaa atg ggg ccg tgg act gca cct cag gtc aca gtg 1027 Arg Glu Ile Ala Glu Met Gly Pro Trp Thr Ala Pro Gln Val Thr Val     295 300 305 ggt gtt att ttt gcg gca gct gca ctg gct tgg gtc ttc att cca tta 1075 Gly Val Ile Phe Ala Ala Ala Ala Leu Ala Trp Val Phe Ile Pro Leu 310 315 320 325 act cta gat tgg acc ggt tcc cag ctc tct atc aat gac tcc ctc att 1123 Thr Leu Asp Trp Thr Gly Ser Gln Leu Ser Ile Asn Asp Ser Leu Ile                 330 335 340 ggc atc gct gcc ggc ctg ctg atg ttt atc gtt ccc gct aac ttt aaa 1171 Gly Ile Ala Ala Gly Leu Leu Met Phe Ile Val Pro Ala Asn Phe Lys             345 350 355 acc ggc gaa cgc att ctt gat tgg cgt act gca ggc gaa ctt cca tgg 1219 Thr Gly Glu Arg Ile Leu Asp Trp Arg Thr Ala Gly Glu Leu Pro Trp         360 365 370 gat gtt ctc ttg ctt ttt ggt ggc ggg ctt tca ctt tct gcg atg ttt 1267 Asp Val Leu Leu Leu Phe Gly Gly Gly Leu Ser Leu Ser Ala Met Phe     375 380 385 acc agc acg gga ctt tcc cta tgg atc ggt gaa cta gct aag gga ctt 1315 Thr Ser Thr Gly Leu Ser Leu Trp Ile Gly Glu Leu Ala Lys Gly Leu 390 395 400 405 gat gcc ctt cca atc ttc att ctc atc ttc gcc att gct gtc ctg gtg 1363 Asp Ala Leu Pro Ile Phe Ile Leu Ile Phe Ala Ile Ala Val Leu Val                 410 415 420 ttg ttc ctg acc gag ttc acc tcc aac acc gca aca gcg gca acc ttc 1411 Leu Phe Leu Thr Glu Phe Thr Ser Asn Thr Ala Thr Ala Ala Thr Phe             425 430 435 ctg cca atc atg ggt ggc gtc gcc gta ggt atc gga ctg acc gca ggt 1459 Leu Pro Ile Met Gly Gly Val Ala Val Gly Ile Gly Leu Thr Ala Gly         440 445 450 ggc gag cag aat gtt ctg ctg ctg acc atc cca gtc gca ctg tcc gca 1507 Gly Glu Gln Asn Val Leu Leu Leu Thr Ile Pro Val Ala Leu Ser Ala     455 460 465 acc tgt gcg ttc atg ctt cca gtg gca acg cct cca aac gcg att gca 1555 Thr Cys Ala Phe Met Leu Pro Val Ala Thr Pro Pro Asn Ala Ile Ala 470 475 480 485 ttc ggc tcc ggc tac att aag atc ggc gaa atg gtc aag ggt ggt ctg 1603 Phe Gly Ser Gly Tyr Ile Lys Ile Gly Glu Met Val Lys Gly Gly Leu                 490 495 500 tgg ctg aac atc atc gca gtc atc ctc att acg att ttc acc tac ttc 1651 Trp Leu Asn Ile Ile Ala Val Ile Leu Ile Thr Ile Phe Thr Tyr Phe             505 510 515 gta gcg atc cca ctc ttt ggc atc atg ctt taaaagttaa caggcccgca 1701 Val Ala Ile Pro Leu Phe Gly Ile Met Leu         520 525 gtc 1704 <210> 516 <211> 527 <212> PRT <213> Corynebacterium glutamicum <400> 516 Met Ser Thr Pro Asp Ile Lys Glu Gly Ser Ala Glu Ser Pro Gly Glu   1 5 10 15 Val Met Val Val Gly Asp Arg Arg Glu Trp Arg Arg Gln Ala Thr Gly              20 25 30 Ile Ile Ala Gly Leu Val Leu Ala Ala Leu Val Tyr Leu Leu Phe Pro          35 40 45 Ser Asn Ser Val Glu Thr Val Met Gln Ser Ser Gly Val Asp Pro Glu      50 55 60 Thr Glu Tyr Thr Asn Asn Ala Met Arg Leu Thr Ala Ala Val Thr Ile  65 70 75 80 Leu Met Ala Val Trp Trp Met Thr Glu Ala Ile Pro Leu Ala Ala Thr                  85 90 95 Ala Leu Ile Pro Leu Val Ala Phe Pro Ala Phe Gln Val Val Asp Phe             100 105 110 Gly Lys Ala Thr Ala Pro Tyr Ala Asn Pro Thr Ser Phe Leu Phe Leu         115 120 125 Gly Gly Phe Leu Met Ala Leu Gly Leu Gln Lys Trp Asn Leu His Arg     130 135 140 Arg Met Ala Leu Ala Val Val Leu Ala Val Gly Thr Lys Pro Lys Gln 145 150 155 160 Leu Val Leu Gly Phe Met Val Ala Thr Gly Phe Leu Ser Met Trp Val                 165 170 175 Ser Asn Thr Ala Thr Ala Val Val Met Leu Pro Ile Gly Met Ser Val             180 185 190 Leu Ala Leu Thr Ala Glu Thr Val Gly Gly Met Lys Asn Gln Lys Lys         195 200 205 Phe Ala Thr Gly Leu Met Leu Ser Ile Ala Tyr Ser Ala Ser Ile Gly     210 215 220 Ser Leu Gly Thr Leu Ile Gly Thr Pro Pro Asn Ala Leu Leu Ala Ala 225 230 235 240 Tyr Met Ser Glu Ser His Asp Ile His Ile Gly Phe Gly Gln Trp Met                 245 250 255 Ile Leu Gly Val Pro Ile Ala Val Val Phe Thr Ile Ile Ala Trp Leu             260 265 270 Val Leu Thr Thr Val Phe Lys Pro Glu Met Lys Glu Ile Pro Gly Gly         275 280 285 Arg Glu Leu Ile Lys Arg Glu Ile Ala Glu Met Gly Pro Trp Thr Ala     290 295 300 Pro Gln Val Thr Val Gly Val Ile Phe Ala Ala Ala Ala Leu Ala Trp 305 310 315 320 Val Phe Ile Pro Leu Thr Leu Asp Trp Thr Gly Ser Gln Leu Ser Ile                 325 330 335 Asn Asp Ser Leu Ile Gly Ile Ala Ala Gly Leu Leu Met Phe Ile Val             340 345 350 Pro Ala Asn Phe Lys Thr Gly Glu Arg Ile Leu Asp Trp Arg Thr Ala         355 360 365 Gly Glu Leu Pro Trp Asp Val Leu Leu Leu Phe Gly Gly Gly Leu Ser     370 375 380 Leu Ser Ala Met Phe Thr Ser Thr Gly Leu Ser Leu Trp Ile Gly Glu 385 390 395 400 Leu Ala Lys Gly Leu Asp Ala Leu Pro Ile Phe Ile Leu Ile Phe Ala                 405 410 415 Ile Ala Val Leu Val Leu Phe Leu Thr Glu Phe Thr Ser Asn Thr Ala             420 425 430 Thr Ala Ala Thr Phe Leu Pro Ile Met Gly Gly Val Ala Val Gly Ile         435 440 445 Gly Leu Thr Ala Gly Gly Glu Gln Asn Val Leu Leu Leu Thr Ile Pro     450 455 460 Val Ala Leu Ser Ala Thr Cys Ala Phe Met Leu Pro Val Ala Thr Pro 465 470 475 480 Pro Asn Ala Ile Ala Phe Gly Ser Gly Tyr Ile Lys Ile Gly Glu Met                 485 490 495 Val Lys Gly Gly Leu Trp Leu Asn Ile Ile Ala Val Ile Leu Ile Thr             500 505 510 Ile Phe Thr Tyr Phe Val Ala Ile Pro Leu Phe Gly Ile Met Leu         515 520 525 <210> 517 <211> 1028 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (1005) <223> FRXA00449 <400> 517 ctg gca ctg acc gct gag act gtg ggc gga atg aaa aac caa aag aaa 48 Leu Ala Leu Thr Ala Glu Thr Val Gly Gly Met Lys Asn Gln Lys Lys   1 5 10 15 ttc gcc act gga ctc atg ctg tcc att gct tat tct gct tcc atc ggt 96 Phe Ala Thr Gly Leu Met Leu Ser Ile Ala Tyr Ser Ala Ser Ile Gly              20 25 30 tca ctc ggc acc tta att ggc acg cca ccc aat gcc ttg ctt gct gcg 144 Ser Leu Gly Thr Leu Ile Gly Thr Pro Pro Asn Ala Leu Leu Ala Ala          35 40 45 tat atg tct gaa tcg cat gat atc cac atc gga ttt ggt cag tgg atg 192 Tyr Met Ser Glu Ser His Asp Ile His Ile Gly Phe Gly Gln Trp Met      50 55 60 att ctt ggt gta cca att gct gtc gtc ttc acc atc atc gcg tgg ctt 240 Ile Leu Gly Val Pro Ile Ala Val Val Phe Thr Ile Ile Ala Trp Leu  65 70 75 80 gtg ttg acc acc gtg ttc aag cca gaa atg aaa gaa atc cct ggc gga 288 Val Leu Thr Thr Val Phe Lys Pro Glu Met Lys Glu Ile Pro Gly Gly                  85 90 95 cgt gaa ctg atc aaa cgt gaa atc gct gaa atg ggg ccg tgg act gca 336 Arg Glu Leu Ile Lys Arg Glu Ile Ala Glu Met Gly Pro Trp Thr Ala             100 105 110 cct cag gtc aca gtg ggt gtt att ttt gcg gca gct gca ctg gct tgg 384 Pro Gln Val Thr Val Gly Val Ile Phe Ala Ala Ala Ala Leu Ala Trp         115 120 125 gtc ttc att cca tta act cta gat tgg acc ggt tcc cag ctc tct atc 432 Val Phe Ile Pro Leu Thr Leu Asp Trp Thr Gly Ser Gln Leu Ser Ile     130 135 140 aat gac tcc ctc att ggc atc gct gcc ggc ctg ctg atg ttt atc gtt 480 Asn Asp Ser Leu Ile Gly Ile Ala Ala Gly Leu Leu Met Phe Ile Val 145 150 155 160 ccc gct aac ttt aaa acc ggc gaa cgc att ctt gat tgg cgt act gca 528 Pro Ala Asn Phe Lys Thr Gly Glu Arg Ile Leu Asp Trp Arg Thr Ala                 165 170 175 ggc gaa ctt cca tgg gat gtt ctc ttg ctt ttt ggt ggc ggg ctt tca 576 Gly Glu Leu Pro Trp Asp Val Leu Leu Leu Phe Gly Gly Gly Leu Ser             180 185 190 ctt tct gcg atg ttt acc agc acg gga ctt tcc cta tgg atc ggt gaa 624 Leu Ser Ala Met Phe Thr Ser Thr Gly Leu Ser Leu Trp Ile Gly Glu         195 200 205 cta gct aag gga ctt gat gcc ctt cca atc ttc att ctc atc ttc gcc 672 Leu Ala Lys Gly Leu Asp Ala Leu Pro Ile Phe Ile Leu Ile Phe Ala     210 215 220 att gct gtc ctg gtg ttg ttc ctg acc gag ttc acc tcc aac acc gca 720 Ile Ala Val Leu Val Leu Phe Leu Thr Glu Phe Thr Ser Asn Thr Ala 225 230 235 240 aca gcg gca acc ttc ctg cca atc atg ggt ggc gtc gcc gta ggt atc 768 Thr Ala Ala Thr Phe Leu Pro Ile Met Gly Gly Val Ala Val Gly Ile                 245 250 255 gga ctg acc gca ggt ggc gag cag aat gtt ctg ctg ctg acc atc cca 816 Gly Leu Thr Ala Gly Gly Glu Gln Asn Val Leu Leu Leu Thr Ile Pro             260 265 270 gtc gca ctg tcc gca acc tgt gcg ttc atg ctt cca gtg gca acg cct 864 Val Ala Leu Ser Ala Thr Cys Ala Phe Met Leu Pro Val Ala Thr Pro         275 280 285 cca aac gcg att gca ttc ggc tcc ggc tac att aag atc ggc gaa atg 912 Pro Asn Ala Ile Ala Phe Gly Ser Gly Tyr Ile Lys Ile Gly Glu Met     290 295 300 gtc aag ggt ggt ctg tgg ctg aac atc atc gca gtc atc ctc att acg 960 Val Lys Gly Gly Leu Trp Leu Asn Ile Ile Ala Val Ile Leu Ile Thr 305 310 315 320 att ttc acc tac ttc gta gcg atc cca ctc ttt ggc atc atg ctt 1005 Ile Phe Thr Tyr Phe Val Ala Ile Pro Leu Phe Gly Ile Met Leu                 325 330 335 taaaagttaa caggcccgca gtc 1028 <210> 518 <211> 335 <212> PRT <213> Corynebacterium glutamicum <400> 518 Leu Ala Leu Thr Ala Glu Thr Val Gly Gly Met Lys Asn Gln Lys Lys   1 5 10 15 Phe Ala Thr Gly Leu Met Leu Ser Ile Ala Tyr Ser Ala Ser Ile Gly              20 25 30 Ser Leu Gly Thr Leu Ile Gly Thr Pro Pro Asn Ala Leu Leu Ala Ala          35 40 45 Tyr Met Ser Glu Ser His Asp Ile His Ile Gly Phe Gly Gln Trp Met      50 55 60 Ile Leu Gly Val Pro Ile Ala Val Val Phe Thr Ile Ile Ala Trp Leu  65 70 75 80 Val Leu Thr Thr Val Phe Lys Pro Glu Met Lys Glu Ile Pro Gly Gly                  85 90 95 Arg Glu Leu Ile Lys Arg Glu Ile Ala Glu Met Gly Pro Trp Thr Ala             100 105 110 Pro Gln Val Thr Val Gly Val Ile Phe Ala Ala Ala Ala Leu Ala Trp         115 120 125 Val Phe Ile Pro Leu Thr Leu Asp Trp Thr Gly Ser Gln Leu Ser Ile     130 135 140 Asn Asp Ser Leu Ile Gly Ile Ala Ala Gly Leu Leu Met Phe Ile Val 145 150 155 160 Pro Ala Asn Phe Lys Thr Gly Glu Arg Ile Leu Asp Trp Arg Thr Ala                 165 170 175 Gly Glu Leu Pro Trp Asp Val Leu Leu Leu Phe Gly Gly Gly Leu Ser             180 185 190 Leu Ser Ala Met Phe Thr Ser Thr Gly Leu Ser Leu Trp Ile Gly Glu         195 200 205 Leu Ala Lys Gly Leu Asp Ala Leu Pro Ile Phe Ile Leu Ile Phe Ala     210 215 220 Ile Ala Val Leu Val Leu Phe Leu Thr Glu Phe Thr Ser Asn Thr Ala 225 230 235 240 Thr Ala Ala Thr Phe Leu Pro Ile Met Gly Gly Val Ala Val Gly Ile                 245 250 255 Gly Leu Thr Ala Gly Gly Glu Gln Asn Val Leu Leu Leu Thr Ile Pro             260 265 270 Val Ala Leu Ser Ala Thr Cys Ala Phe Met Leu Pro Val Ala Thr Pro         275 280 285 Pro Asn Ala Ile Ala Phe Gly Ser Gly Tyr Ile Lys Ile Gly Glu Met     290 295 300 Val Lys Gly Gly Leu Trp Leu Asn Ile Ile Ala Val Ile Leu Ile Thr 305 310 315 320 Ile Phe Thr Tyr Phe Val Ala Ile Pro Leu Phe Gly Ile Met Leu                 325 330 335 <210> 519 <211> 448 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (448) <223> FRXA01755 <400> 519 tcgttggctt acatggtcat tgatgaccgg gctgaatatg tgagaaaatc catcccttct 60 ttaagcaagg gagtgaatta cagaaaagga ttgttcagca atg agc aca cct gac 115                                             Met Ser Thr Pro Asp                                               1 5 att aaa gaa ggc tcg gca gaa tca ccg ggc gaa gta atg gtc gtt gga 163 Ile Lys Glu Gly Ser Ala Glu Ser Pro Gly Glu Val Met Val Val Gly                  10 15 20 gac agg cga gag tgg cgt cga caa gca acc ggc atc att gcc ggc ctc 211 Asp Arg Arg Glu Trp Arg Arg Gln Ala Thr Gly Ile Ile Ala Gly Leu              25 30 35 gtc tta gcc gcc ctg gtc tat ctt ctc ttc ccc tcg aac tcc gtg gaa 259 Val Leu Ala Ala Leu Val Tyr Leu Leu Phe Pro Ser Asn Ser Val Glu          40 45 50 acc gtc atg caa tcc agt ggc gtc gat cca gaa act gaa tac acc aac 307 Thr Val Met Gln Ser Ser Gly Val Asp Pro Glu Thr Glu Tyr Thr Asn      55 60 65 aac gcg atg cgt ctt act gct gca gtc aca atc ttg atg gca gtg tgg 355 Asn Ala Met Arg Leu Thr Ala Ala Val Thr Ile Leu Met Ala Val Trp  70 75 80 85 tgg atg aca gaa gca atc cca cta gca gca acc gca ctt atc ccg ttg 403 Trp Met Thr Glu Ala Ile Pro Leu Ala Ala Thr Ala Leu Ile Pro Leu                  90 95 100 gtt gca ttc cct gct ttc cag gtt gtg gac ttt ggg aag gca gca 448 Val Ala Phe Pro Ala Phe Gln Val Val Asp Phe Gly Lys Ala Ala             105 110 115 <210> 520 <211> 116 <212> PRT <213> Corynebacterium glutamicum <400> 520 Met Ser Thr Pro Asp Ile Lys Glu Gly Ser Ala Glu Ser Pro Gly Glu   1 5 10 15 Val Met Val Val Gly Asp Arg Arg Glu Trp Arg Arg Gln Ala Thr Gly              20 25 30 Ile Ile Ala Gly Leu Val Leu Ala Ala Leu Val Tyr Leu Leu Phe Pro          35 40 45 Ser Asn Ser Val Glu Thr Val Met Gln Ser Ser Gly Val Asp Pro Glu      50 55 60 Thr Glu Tyr Thr Asn Asn Ala Met Arg Leu Thr Ala Ala Val Thr Ile  65 70 75 80 Leu Met Ala Val Trp Trp Met Thr Glu Ala Ile Pro Leu Ala Ala Thr                  85 90 95 Ala Leu Ile Pro Leu Val Ala Phe Pro Ala Phe Gln Val Val Asp Phe             100 105 110 Gly Lys Ala Ala         115 <210> 521 <211> 912 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (889) <223> RXA00269 <400> 521 tgcgatcttg gtggttgtcg ccatgctgct gccgaggtgg cgtgcgaagt tctccaaggc 60 accgaagcct aagcaaccag tagcagtgga ggcttaagac atg tta tcc atc aac 115                                             Met leu ser ile asn                                               1 5 gga att tct aag acg ttc ttc ccc ggc act gtg aat gag cgc cgc gcg 163 Gly Ile Ser Lys Thr Phe Phe Pro Gly Thr Val Asn Glu Arg Arg Ala                  10 15 20 ttg cag cag ctc aaa ctc gat atg gct gag ggc gat ttt gtc acc gtc 211 Leu Gln Gln Leu Lys Leu Asp Met Ala Glu Gly Asp Phe Val Thr Val              25 30 35 atc ggt tct aac ggt gcg ggt aaa tcc acg ctg ctc aac gct gtt tct 259 Ile Gly Ser Asn Gly Ala Gly Lys Ser Thr Leu Leu Asn Ala Val Ser          40 45 50 ggc cgt ttg ctt gtt gat tcc ggc gag att tcc atc gac ggc aac aag 307 Gly Arg Leu Leu Val Asp Ser Gly Glu Ile Ser Ile Asp Gly Asn Lys      55 60 65 gta aac aag atg tca gag cac aag cgt gcc cgc tac atc ggc cgc gtt 355 Val Asn Lys Met Ser Glu His Lys Arg Ala Arg Tyr Ile Gly Arg Val  70 75 80 85 ttc cag gat cct ctg gcc ggc acc gcg ccg aat ctc acc att gaa gag 403 Phe Gln Asp Pro Leu Ala Gly Thr Ala Pro Asn Leu Thr Ile Glu Glu                  90 95 100 aat ctg gcc atc gcg ttg ctg cgc ggc aag cgc cgt gga ttg ggc ttt 451 Asn Leu Ala Ile Ala Leu Leu Arg Gly Lys Arg Arg Gly Leu Gly Phe             105 110 115 gca ctg acc tcg aag cgc cgt gag caa ttc aag cag gaa ctt gag cgc 499 Ala Leu Thr Ser Lys Arg Arg Glu Gln Phe Lys Gln Glu Leu Glu Arg         120 125 130 ctt gag ctg ggt ctg gaa aac agg ctc act gcc aaa gtt ggt ttg ctc 547 Leu Glu Leu Gly Leu Glu Asn Arg Leu Thr Ala Lys Val Gly Leu Leu     135 140 145 tct ggc ggt cag cgt cag gca ttg tcc ctg ctg atg gct ggt ttt act 595 Ser Gly Gly Gln Arg Gln Ala Leu Ser Leu Leu Met Ala Gly Phe Thr 150 155 160 165 caa cct aaa atc atg ctg ttg gat gag cac acc gca gcg ctt gat cca 643 Gln Pro Lys Ile Met Leu Leu Asp Glu His Thr Ala Ala Leu Asp Pro                 170 175 180 cag cgt gca gag ctt gtg acc acc ttg acc gaa aag atc gtg gca gat 691 Gln Arg Ala Glu Leu Val Thr Thr Leu Thr Glu Lys Ile Val Ala Asp             185 190 195 gga aat ctg act acg ctt atg gtc acg cac aac atg gaa cag gca att 739 Gly Asn Leu Thr Thr Leu Met Val Thr His Asn Met Glu Gln Ala Ile         200 205 210 cgc ctg ggc aat cgc ctg atc atg atg cat gaa ggc cag att gtc tac 787 Arg Leu Gly Asn Arg Leu Ile Met Met His Glu Gly Gln Ile Val Tyr     215 220 225 cag gca gat cag gct acc aag tcg aag ttg act gtg cgc gat ttg ctg 835 Gln Ala Asp Gln Ala Thr Lys Ser Lys Leu Thr Val Arg Asp Leu Leu 230 235 240 245 cag gag ttc gcc aac atc aag ggc gca aca ttg tct gac aag gcg ttc 883 Gln Glu Phe Ala Asn Ile Lys Gly Ala Thr Leu Ser Asp Lys Ala Phe                 250 255 260 ctc ggc taaaaagagc ttgctttacg acg 912 Leu gly <210> 522 <211> 263 <212> PRT <213> Corynebacterium glutamicum <400> 522 Met Leu Ser Ile Asn Gly Ile Ser Lys Thr Phe Phe Pro Gly Thr Val   1 5 10 15 Asn Glu Arg Arg Ala Leu Gln Gln Leu Lys Leu Asp Met Ala Glu Gly              20 25 30 Asp Phe Val Thr Val Ile Gly Ser Asn Gly Ala Gly Lys Ser Thr Leu          35 40 45 Leu Asn Ala Val Ser Gly Arg Leu Leu Val Asp Ser Gly Glu Ile Ser      50 55 60 Ile Asp Gly Asn Lys Val Asn Lys Met Ser Glu His Lys Arg Ala Arg  65 70 75 80 Tyr Ile Gly Arg Val Phe Gln Asp Pro Leu Ala Gly Thr Ala Pro Asn                  85 90 95 Leu Thr Ile Glu Glu Asn Leu Ala Ile Ala Leu Leu Arg Gly Lys Arg             100 105 110 Arg Gly Leu Gly Phe Ala Leu Thr Ser Lys Arg Arg Glu Gln Phe Lys         115 120 125 Gln Glu Leu Glu Arg Leu Glu Leu Gly Leu Glu Asn Arg Leu Thr Ala     130 135 140 Lys Val Gly Leu Leu Ser Gly Gly Gln Arg Gln Ala Leu Ser Leu Leu 145 150 155 160 Met Ala Gly Phe Thr Gln Pro Lys Ile Met Leu Leu Asp Glu His Thr                 165 170 175 Ala Ala Leu Asp Pro Gln Arg Ala Glu Leu Val Thr Thr Leu Thr Glu             180 185 190 Lys Ile Val Ala Asp Gly Asn Leu Thr Thr Leu Met Val Thr His Asn         195 200 205 Met Glu Gln Ala Ile Arg Leu Gly Asn Arg Leu Ile Met Met His Glu     210 215 220 Gly Gln Ile Val Tyr Gln Ala Asp Gln Ala Thr Lys Ser Lys Leu Thr 225 230 235 240 Val Arg Asp Leu Leu Gln Glu Phe Ala Asn Ile Lys Gly Ala Thr Leu                 245 250 255 Ser Asp Lys Ala Phe Leu Gly             260 <210> 523 <211> 817 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (817) <223> RXA00369 <400> 523 ggcgggaaat tacaatcagg catcggcgtt gtcgttgatg tttgcgatta tcggtatcgt 60 ggcgctcgcg ttgacggtgc gcagccagaa ggagttttag gtg tca tcg atc aaa 115                                             Val Ser Ser Ile Lys                                               1 5 ttg cgc gat tta agc gtg agc ttc cgc gac gga acc ttc ggg ctg caa 163 Leu Arg Asp Leu Ser Val Ser Phe Arg Asp Gly Thr Phe Gly Leu Gln                  10 15 20 gat atc aat ttg aaa att gag ccg gaa gaa ttt gtg gtg ctc atc ggg 211 Asp Ile Asn Leu Lys Ile Glu Pro Glu Glu Phe Val Val Leu Ile Gly              25 30 35 ccg tcg ggg tcc ggt aaa acc acc atg ttg ggc acc atc gcg ggg ttt 259 Pro Ser Gly Ser Gly Lys Thr Thr Met Leu Gly Thr Ile Ala Gly Phe          40 45 50 gtg gag cca agt tcc ggc agt gtg ctc atc gcc ggc gaa gaa atg acg 307 Val Glu Pro Ser Ser Gly Ser Val Leu Ile Ala Gly Glu Glu Met Thr      55 60 65 cat gtc ccg ccg gag cgc cgt cgc atg ggc atg gtg ttt cag cag cat 355 His Val Pro Pro Glu Arg Arg Arg Met Gly Met Val Phe Gln Gln His  70 75 80 85 gcg gtg tgg ccg cat atg tcg gtc gcc aag aat gtg gga tac ccg ctg 403 Ala Val Trp Pro His Met Ser Val Ala Lys Asn Val Gly Tyr Pro Leu                  90 95 100 gcg cga agt ggt cag aag ggg gcg tcg ata agc aaa cgc gtg gag cgc 451 Ala Arg Ser Gly Gln Lys Gly Ala Ser Ile Ser Lys Arg Val Glu Arg             105 110 115 acg ctc gcg ctg gtg ggg ctt gag ggg ttc ggc agt cgc aga ccg gcc 499 Thr Leu Ala Leu Val Gly Leu Glu Gly Phe Gly Ser Arg Arg Pro Ala         120 125 130 agc ctg tct ggt ggt caa cgt cag cgg gtg gcg ctt gcg cgc gcc atc 547 Ser Leu Ser Gly Gly Gln Arg Gln Arg Val Ala Leu Ala Arg Ala Ile     135 140 145 atc gcc gac ccc acc gtg ctg ctt ctc gac gag gcc ctc tcc gcc ctc 595 Ile Ala Asp Pro Thr Val Leu Leu Leu Asp Glu Ala Leu Ser Ala Leu 150 155 160 165 gac gaa ccg ctg cga gac gct tta cga cgc gaa ctc gta tct ttg acc 643 Asp Glu Pro Leu Arg Asp Ala Leu Arg Arg Glu Leu Val Ser Leu Thr                 170 175 180 cgg cgc gaa ggc ctc act act gtg cac gtg acg cat gac cgc gcc gaa 691 Arg Arg Glu Gly Leu Thr Thr Val His Val Thr His Asp Arg Ala Glu             185 190 195 gcg atc tcc atc gct gac cgc atc gtc gta ctc ggc aac ggt cga atc 739 Ala Ile Ser Ile Ala Asp Arg Ile Val Val Leu Gly Asn Gly Arg Ile         200 205 210 caa cag gta gcc acc cct act gag ctc ctt tcc gcc ccc gct act gcc 787 Gln Gln Val Ala Thr Pro Thr Glu Leu Leu Ser Ala Pro Ala Thr Ala     215 220 225 gat gtt gcc cga ttc atc gtc gac gcc acc 817 Asp Val Ala Arg Phe Ile Val Asp Ala Thr 230 235 <210> 524 <211> 239 <212> PRT <213> Corynebacterium glutamicum <400> 524 Val Ser Ser Ile Lys Leu Arg Asp Leu Ser Val Ser Phe Arg Asp Gly   1 5 10 15 Thr Phe Gly Leu Gln Asp Ile Asn Leu Lys Ile Glu Pro Glu Glu Phe              20 25 30 Val Val Leu Ile Gly Pro Ser Gly Ser Gly Lys Thr Thr Met Leu Gly          35 40 45 Thr Ile Ala Gly Phe Val Glu Pro Ser Ser Gly Ser Val Leu Ile Ala      50 55 60 Gly Glu Glu Met Thr His Val Pro Pro Glu Arg Arg Arg Met Gly Met  65 70 75 80 Val Phe Gln Gln His Ala Val Trp Pro His Met Ser Val Ala Lys Asn                  85 90 95 Val Gly Tyr Pro Leu Ala Arg Ser Gly Gln Lys Gly Ala Ser Ile Ser             100 105 110 Lys Arg Val Glu Arg Thr Leu Ala Leu Val Gly Leu Glu Gly Phe Gly         115 120 125 Ser Arg Arg Pro Ala Ser Leu Ser Gly Gly Gln Arg Gln Arg Val Ala     130 135 140 Leu Ala Arg Ala Ile Ile Ala Asp Pro Thr Val Leu Leu Leu Asp Glu 145 150 155 160 Ala Leu Ser Ala Leu Asp Glu Pro Leu Arg Asp Ala Leu Arg Arg Glu                 165 170 175 Leu Val Ser Leu Thr Arg Arg Glu Gly Leu Thr Thr Val His Val Thr             180 185 190 His Asp Arg Ala Glu Ala Ile Ser Ile Ala Asp Arg Ile Val Val Leu         195 200 205 Gly Asn Gly Arg Ile Gln Gln Val Ala Thr Pro Thr Glu Leu Leu Ser     210 215 220 Ala Pro Ala Thr Ala Asp Val Ala Arg Phe Ile Val Asp Ala Thr 225 230 235 <210> 525 <211> 1653 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1630) <223> RXA02073 <400> 525 tcattgtttt agaggatggc caattgacca tgatggatac acccagcaac gtttcccagc 60 acaatgcgtt tttccgcacc gctgtgatgg aggaagaaca atg att tcc cga ctt 115                                             Met Ile Ser Arg Leu                                               1 5 ctc caa ttg gct aag aaa gta tgg ccg gaa ctt gga gcc tcc acg ctc 163 Leu Gln Leu Ala Lys Lys Val Trp Pro Glu Leu Gly Ala Ser Thr Leu                  10 15 20 ctg cga ctg ctc aat cag cta ctc acc gca gca ctc att gtg ttc ccc 211 Leu Arg Leu Leu Asn Gln Leu Leu Thr Ala Ala Leu Ile Val Phe Pro              25 30 35 gcc tgg gtg cta agc cgc aaa cca gac atc tcc ctg ctc gcc gtc gcc 259 Ala Trp Val Leu Ser Arg Lys Pro Asp Ile Ser Leu Leu Ala Val Ala          40 45 50 atc atc atg gcg ctc atc gcg ctg aca gca gct gtc tgt cgc tgg ggt 307 Ile Ile Met Ala Leu Ile Ala Leu Thr Ala Ala Val Cys Arg Trp Gly      55 60 65 gag cag gta tgc ggc cac cgc gct gcc ttt ggg ctg ctt gcc cac atg 355 Glu Gln Val Cys Gly His Arg Ala Ala Phe Gly Leu Leu Ala His Met  70 75 80 85 cgc gtt atg ctt tac gac gcc ctc gtc cac aaa ggt tcc ccc tcg ccg 403 Arg Val Met Leu Tyr Asp Ala Leu Val His Lys Gly Ser Pro Ser Pro                  90 95 100 atc cac ggc agc ggt tcg atc atg tct gtt gcc acc cgt gac att aac 451 Ile His Gly Ser Gly Ser Ile Met Ser Val Ala Thr Arg Asp Ile Asn             105 110 115 tcc atc gaa gta ttc ttc gcg cac acc att ggg cct aca gtc acc gca 499 Ser Ile Glu Val Phe Phe Ala His Thr Ile Gly Pro Thr Val Thr Ala         120 125 130 gtg ctg ctc agt gcg gga ggc gtg atc acg ctg gca acg ctc gat ccc 547 Val Leu Leu Ser Ala Gly Gly Val Ile Thr Leu Ala Thr Leu Asp Pro     135 140 145 gtt gct ggt cta att ggt tta ctc ggt gtc ctc atc gcg tgg ttg atc 595 Val Ala Gly Leu Ile Gly Leu Leu Gly Val Leu Ile Ala Trp Leu Ile 150 155 160 165 ccc ttg att gga aaa caa tcc tca agc agt gaa gcc aca tca cgt gga 643 Pro Leu Ile Gly Lys Gln Ser Ser Ser Ser Glu Ala Thr Ser Arg Gly                 170 175 180 cac atc gcc cag cac ctc acc gaa gat gcc gcc ggc agg ctt gaa atc 691 His Ile Ala Gln His Leu Thr Glu Asp Ala Ala Gly Arg Leu Glu Ile             185 190 195 aac tca cat gga gcg caa gcc aca cgg tta aat gcg ctc gag gtg aaa 739 Asn Ser His Gly Ala Gln Ala Thr Arg Leu Asn Ala Leu Glu Val Lys         200 205 210 gag caa caa ctg gaa caa gtt gtg acc cga cag ggc ttg atc gtc ggt 787 Glu Gln Gln Leu Glu Gln Val Val Thr Arg Gln Gly Leu Ile Val Gly     215 220 225 atc cgt cag ggc gca gca ctt tta tgg ccg tgg ata tca gct gtg ttg 835 Ile Arg Gln Gly Ala Ala Leu Leu Trp Pro Trp Ile Ser Ala Val Leu 230 235 240 245 ttg gtt gct ctg gtt cct cat gtg ggc att gtt gca gcc gcg att atc 883 Leu Val Ala Leu Val Pro His Val Gly Ile Val Ala Ala Ala Ile Ile                 250 255 260 ctg ggc atc tcc cct gcg ttg gat gca gtt gag gga ttt gct cgc acc 931 Leu Gly Ile Ser Pro Ala Leu Asp Ala Val Glu Gly Phe Ala Arg Thr             265 270 275 atg cct acc gcg tta aac agt gcg cag cgg tat ttc cag atc atc gat 979 Met Pro Thr Ala Leu Asn Ser Ala Gln Arg Tyr Phe Gln Ile Ile Asp         280 285 290 gcc cct gtt gct atc gct gaa cct gac gag ccg aag cct ttg ccc aaa 1027 Ala Pro Val Ala Ile Ala Glu Pro Asp Glu Pro Lys Pro Leu Pro Lys     295 300 305 ggc ccg ctt aag ctg cga att tct aga gtt cca gtc agc gca aag ggc 1075 Gly Pro Leu Lys Leu Arg Ile Ser Arg Val Pro Val Ser Ala Lys Gly 310 315 320 325 acc gtg tct tta gag gtt gca gct ggt gaa cac atc ggc atc atc gga 1123 Thr Val Ser Leu Glu Val Ala Ala Gly Glu His Ile Gly Ile Ile Gly                 330 335 340 tcc agc ggt agt gga aaa tcc act ttg gcc aaa ctc atc ctc aag ctg 1171 Ser Ser Gly Ser Gly Lys Ser Thr Leu Ala Lys Leu Ile Leu Lys Leu             345 350 355 gcg caa cta cgg tct gga acc atc acc atc ggt ggt gtt gat atc gca 1219 Ala Gln Leu Arg Ser Gly Thr Ile Thr Ile Gly Gly Val Asp Ile Ala         360 365 370 gag gtt tca tcg gcg gag ctt cgc aaa tcc gtc acg ctg gtt gag cag 1267 Glu Val Ser Ser Ala Glu Leu Arg Lys Ser Val Thr Leu Val Glu Gln     375 380 385 aaa tct gtg ctg ttt aga gca agc gtg ctg gag aat tta cgg atg ggc 1315 Lys Ser Val Leu Phe Arg Ala Ser Val Leu Glu Asn Leu Arg Met Gly 390 395 400 405 aat cca gag ctg tct gaa gat gaa gca agg gaa gcc ttg agg ttg gcg 1363 Asn Pro Glu Leu Ser Glu Asp Glu Ala Arg Glu Ala Leu Arg Leu Ala                 410 415 420 tcg ata agc gaa ctg cct tta gat gct gac gcc ctg cgc cta tct ggc 1411 Ser Ile Ser Glu Leu Pro Leu Asp Ala Asp Ala Leu Arg Leu Ser Gly             425 430 435 gga cag caa caa cgg ctc tgc ctg gcg cgt gct ttg gca cgc acc cct 1459 Gly Gln Gln Gln Arg Leu Cys Leu Ala Arg Ala Leu Ala Arg Thr Pro         440 445 450 cag gta ctg att gtc gat gaa gcc acc agc cac caa gat gcg ctc aat 1507 Gln Val Leu Ile Val Asp Glu Ala Thr Ser His Gln Asp Ala Leu Asn     455 460 465 caa gcg gat ctt tcc cag act ctg gcc acg ctt aaa gac acc acg gtg 1555 Gln Ala Asp Leu Ser Gln Thr Leu Ala Thr Leu Lys Asp Thr Thr Val 470 475 480 485 atc atc att gcg cac cgc aca gct gca tta acc cat gtg gat cgg ata 1603 Ile Ile Ile Ala His Arg Thr Ala Ala Leu Thr His Val Asp Arg Ile                 490 495 500 att gac ctg gaa gaa atc aaa aat ccc tgatccttaa cgcggatcag 1650 Ile Asp Leu Glu Glu Ile Lys Asn Pro             505 510 ggg 1653 <210> 526 <211> 510 <212> PRT <213> Corynebacterium glutamicum <400> 526 Met Ile Ser Arg Leu Leu Gln Leu Ala Lys Lys Val Trp Pro Glu Leu   1 5 10 15 Gly Ala Ser Thr Leu Leu Arg Leu Leu Asn Gln Leu Leu Thr Ala Ala              20 25 30 Leu Ile Val Phe Pro Ala Trp Val Leu Ser Arg Lys Pro Asp Ile Ser          35 40 45 Leu Leu Ala Val Ala Ile Ile Met Ala Leu Ile Ala Leu Thr Ala Ala      50 55 60 Val Cys Arg Trp Gly Glu Gln Val Cys Gly His Arg Ala Ala Phe Gly  65 70 75 80 Leu Leu Ala His Met Arg Val Met Leu Tyr Asp Ala Leu Val His Lys                  85 90 95 Gly Ser Pro Ser Pro Ile His Gly Ser Gly Ser Ile Met Ser Val Ala             100 105 110 Thr Arg Asp Ile Asn Ser Ile Glu Val Phe Phe Ala His Thr Ile Gly         115 120 125 Pro Thr Val Thr Ala Val Leu Leu Ser Ala Gly Gly Val Ile Thr Leu     130 135 140 Ala Thr Leu Asp Pro Val Ala Gly Leu Ile Gly Leu Leu Gly Val Leu 145 150 155 160 Ile Ala Trp Leu Ile Pro Leu Ile Gly Lys Gln Ser Ser Ser Ser Glu                 165 170 175 Ala Thr Ser Arg Gly His Ile Ala Gln His Leu Thr Glu Asp Ala Ala             180 185 190 Gly Arg Leu Glu Ile Asn Ser His Gly Ala Gln Ala Thr Arg Leu Asn         195 200 205 Ala Leu Glu Val Lys Glu Gln Gln Leu Glu Gln Val Val Thr Arg Gln     210 215 220 Gly Leu Ile Val Gly Ile Arg Gln Gly Ala Ala Leu Leu Trp Pro Trp 225 230 235 240 Ile Ser Ala Val Leu Leu Val Ala Leu Val Pro His Val Gly Ile Val                 245 250 255 Ala Ala Ala Ile Ile Leu Gly Ile Ser Pro Ala Leu Asp Ala Val Glu             260 265 270 Gly Phe Ala Arg Thr Met Pro Thr Ala Leu Asn Ser Ala Gln Arg Tyr         275 280 285 Phe Gln Ile Ile Asp Ala Pro Val Ala Ile Ala Glu Pro Asp Glu Pro     290 295 300 Lys Pro Leu Pro Lys Gly Pro Leu Lys Leu Arg Ile Ser Arg Val Pro 305 310 315 320 Val Ser Ala Lys Gly Thr Val Ser Leu Glu Val Ala Ala Gly Glu His                 325 330 335 Ile Gly Ile Ile Gly Ser Ser Gly Ser Gly Lys Ser Thr Leu Ala Lys             340 345 350 Leu Ile Leu Lys Leu Ala Gln Leu Arg Ser Gly Thr Ile Thr Ile Gly         355 360 365 Gly Val Asp Ile Ala Glu Val Ser Ser Ala Glu Leu Arg Lys Ser Val     370 375 380 Thr Leu Val Glu Gln Lys Ser Val Leu Phe Arg Ala Ser Val Leu Glu 385 390 395 400 Asn Leu Arg Met Gly Asn Pro Glu Leu Ser Glu Asp Glu Ala Arg Glu                 405 410 415 Ala Leu Arg Leu Ala Ser Ile Ser Glu Leu Pro Leu Asp Ala Asp Ala             420 425 430 Leu Arg Leu Ser Gly Gly Gln Gln Gln Arg Leu Cys Leu Ala Arg Ala         435 440 445 Leu Ala Arg Thr Pro Gln Val Leu Ile Val Asp Glu Ala Thr Ser His     450 455 460 Gln Asp Ala Leu Asn Gln Ala Asp Leu Ser Gln Thr Leu Ala Thr Leu 465 470 475 480 Lys Asp Thr Thr Val Val Ile Ile Ala His Arg Thr Ala Ala Leu Thr                 485 490 495 His Val Asp Arg Ile Ile Asp Leu Glu Glu Ile Lys Asn Pro             500 505 510 <210> 527 <211> 1142 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (1119) <223> RXA01399 <400> 527 att ctc agc ccc gca acc gca ctt gtc ctg gcg att gga ttg att gct 48 Ile Leu Ser Pro Ala Thr Ala Leu Val Leu Ala Ile Gly Leu Ile Ala   1 5 10 15 gct gca att atc cct ccc ctg ctt gct gct cgc gga gtt aaa aca gcc 96 Ala Ala Ile Ile Pro Pro Leu Leu Ala Ala Arg Gly Val Lys Thr Ala              20 25 30 gaa gcc cgg cgc gct gaa tcc agc gaa gcc tac ttg agt tcc ttg gat 144 Glu Ala Arg Arg Ala Glu Ser Ser Glu Ala Tyr Leu Ser Ser Leu Asp          35 40 45 cag gtg ctg tcc aac cag gcg gcg ctt cgt gtt cgt ggt gaa atg ccg 192 Gln Val Leu Ser Asn Gln Ala Ala Leu Arg Val Arg Gly Glu Met Pro      50 55 60 gcc gct ctg tcc aag gcg gat gtg gct gcg cgt tcc tat tct tct tca 240 Ala Ala Leu Ser Lys Ala Asp Val Ala Ala Arg Ser Tyr Ser Ser Ser  65 70 75 80 ctg gag gca ggc gcg aaa gac act gcc att ggc gca gcg agt tcc ctg 288 Leu Glu Ala Gly Ala Lys Asp Thr Ala Ile Gly Ala Ala Ser Ser Leu                  85 90 95 tgg att cac ggt ttc act gtc att ggt gtg ctc atg gtt tcc gcg tca 336 Trp Ile His Gly Phe Thr Val Ile Gly Val Leu Met Val Ser Ala Ser             100 105 110 ctg tat gca gat gga agc cat tca ccg cag tgg ttt ggt gtg ttg gtg 384 Leu Tyr Ala Asp Gly Ser His Ser Pro Gln Trp Phe Gly Val Leu Val         115 120 125 ctg ctt tca ctc gca gct ttc gag gct gtc tct gtt ctc ccc gat gct 432 Leu Leu Ser Leu Ala Ala Phe Glu Ala Val Ser Val Leu Pro Asp Ala     130 135 140 gcg att gct cgt acc cgc gcc gca gat gcc acc agg agg ctt gcg gaa 480 Ala Ile Ala Arg Thr Arg Ala Ala Asp Ala Thr Arg Arg Leu Ala Glu 145 150 155 160 atc tcg gcg ctg cca gaa tct gtc tct ctt gag ctt cgc acg gcc tct 528 Ile Ser Ala Leu Pro Glu Ser Val Ser Leu Glu Leu Arg Thr Ala Ser                 165 170 175 gac cag ccc gta tta cgc gcc gag aat cta gtt tat gga tgg gac agc 576 Asp Gln Pro Val Leu Arg Ala Glu Asn Leu Val Tyr Gly Trp Asp Ser             180 185 190 gac cta ggc acg agc aac ctg gat ctc acc ttt ggt tca cga cat gaa 624 Asp Leu Gly Thr Ser Asn Leu Asp Leu Thr Phe Gly Ser Arg His Glu         195 200 205 atc atc gca ccc tct gga act ggc aaa acg acc ctg ctg ctc aca ctt 672 Ile Ile Ala Pro Ser Gly Thr Gly Lys Thr Thr Leu Leu Leu Thr Leu     210 215 220 gcg ggg ctg ttg gaa cct cgt gga ggc caa gtg ctt atc gac ggc acc 720 Ala Gly Leu Leu Glu Pro Arg Gly Gly Gln Val Leu Ile Asp Gly Thr 225 230 235 240 aat cct tcc gag ttg aaa aac gcc gtg ctg ttc agt cca gaa gat gcc 768 Asn Pro Ser Glu Leu Lys Asn Ala Val Leu Phe Ser Pro Glu Asp Ala                 245 250 255 cac att ttt gcc acc act gtc cga gat aac tta gca ctc gga gca ccg 816 His Ile Phe Ala Thr Thr Val Arg Asp Asn Leu Ala Leu Gly Ala Pro             260 265 270 gaa gca acc gac gcg gaa atg aca tcg atc ctg gaa cat gtt ggt ttg 864 Glu Ala Thr Asp Ala Glu Met Thr Ser Ile Leu Glu His Val Gly Leu         275 280 285 tca gag tgg gtt caa ggt tta ccc gat ggt ctt ggc act gtc ctt gat 912 Ser Glu Trp Val Gln Gly Leu Pro Asp Gly Leu Gly Thr Val Leu Asp     290 295 300 tca ggt gcc gat agt ctc tcg gga ggt cag cgc cgc cgc ctg ctc ctt 960 Ser Gly Ala Asp Ser Leu Ser Gly Gly Gln Arg Arg Arg Leu Leu Leu 305 310 315 320 gcc cgc gta cta cta agt gat gca cca att ctg ctt ttg gat gaa ccc 1008 Ala Arg Val Leu Leu Ser Asp Ala Pro Ile Leu Leu Leu Asp Glu Pro                 325 330 335 acc gag cac ctc gac act gca ggc tcc tct gaa atc ttg tct atg ctg 1056 Thr Glu His Leu Asp Thr Ala Gly Ser Ser Glu Ile Leu Ser Met Leu             340 345 350 gcc tcc gat gaa ctc cct ggt aaa aga gct agg aga acc gta gtg att 1104 Ala Ser Asp Glu Leu Pro Gly Lys Arg Ala Arg Arg Thr Val Val Ile         355 360 365 gtg agg cat gtg agg taattttgcc ccgctgtctt ctg 1142 Val Arg His Val Arg     370 <210> 528 <211> 373 <212> PRT <213> Corynebacterium glutamicum <400> 528 Ile Leu Ser Pro Ala Thr Ala Leu Val Leu Ala Ile Gly Leu Ile Ala   1 5 10 15 Ala Ala Ile Ile Pro Pro Leu Leu Ala Ala Arg Gly Val Lys Thr Ala              20 25 30 Glu Ala Arg Arg Ala Glu Ser Ser Glu Ala Tyr Leu Ser Ser Leu Asp          35 40 45 Gln Val Leu Ser Asn Gln Ala Ala Leu Arg Val Arg Gly Glu Met Pro      50 55 60 Ala Ala Leu Ser Lys Ala Asp Val Ala Ala Arg Ser Tyr Ser Ser Ser  65 70 75 80 Leu Glu Ala Gly Ala Lys Asp Thr Ala Ile Gly Ala Ala Ser Ser Leu                  85 90 95 Trp Ile His Gly Phe Thr Val Ile Gly Val Leu Met Val Ser Ala Ser             100 105 110 Leu Tyr Ala Asp Gly Ser His Ser Pro Gln Trp Phe Gly Val Leu Val         115 120 125 Leu Leu Ser Leu Ala Ala Phe Glu Ala Val Ser Val Leu Pro Asp Ala     130 135 140 Ala Ile Ala Arg Thr Arg Ala Ala Asp Ala Thr Arg Arg Leu Ala Glu 145 150 155 160 Ile Ser Ala Leu Pro Glu Ser Val Ser Leu Glu Leu Arg Thr Ala Ser                 165 170 175 Asp Gln Pro Val Leu Arg Ala Glu Asn Leu Val Tyr Gly Trp Asp Ser             180 185 190 Asp Leu Gly Thr Ser Asn Leu Asp Leu Thr Phe Gly Ser Arg His Glu         195 200 205 Ile Ile Ala Pro Ser Gly Thr Gly Lys Thr Thr Leu Leu Leu Thr Leu     210 215 220 Ala Gly Leu Leu Glu Pro Arg Gly Gly Gln Val Leu Ile Asp Gly Thr 225 230 235 240 Asn Pro Ser Glu Leu Lys Asn Ala Val Leu Phe Ser Pro Glu Asp Ala                 245 250 255 His Ile Phe Ala Thr Thr Val Arg Asp Asn Leu Ala Leu Gly Ala Pro             260 265 270 Glu Ala Thr Asp Ala Glu Met Thr Ser Ile Leu Glu His Val Gly Leu         275 280 285 Ser Glu Trp Val Gln Gly Leu Pro Asp Gly Leu Gly Thr Val Leu Asp     290 295 300 Ser Gly Ala Asp Ser Leu Ser Gly Gly Gln Arg Arg Arg Leu Leu Leu 305 310 315 320 Ala Arg Val Leu Leu Ser Asp Ala Pro Ile Leu Leu Leu Asp Glu Pro                 325 330 335 Thr Glu His Leu Asp Thr Ala Gly Ser Ser Glu Ile Leu Ser Met Leu             340 345 350 Ala Ser Asp Glu Leu Pro Gly Lys Arg Ala Arg Arg Thr Val Val Ile         355 360 365 Val Arg His Val Arg     370 <210> 529 <211> 1368 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1345) <223> RXA01339 <400> 529 gagaaggcgg aaccgaagga atcgaagaat atctctccgt gcgttacctc gctttgccgt 60 gacacatgag ctgtccggtg aataacccga aggaaaaaac atg act acc gaa tca 115                                             Met Thr Thr Glu Ser                                               1 5 ata gtt gcg cac aat gct gca ggt aca gca cct cag aat gtg tcc tct 163 Ile Val Ala His Asn Ala Ala Gly Thr Ala Pro Gln Asn Val Ser Ser                  10 15 20 gct aag aag aag tac ctc agc gtt gcc caa ggc gtt gcc ctt atc tac 211 Ala Lys Lys Lys Tyr Leu Ser Val Ala Gln Gly Val Ala Leu Ile Tyr              25 30 35 gga acc aac atc ggc gcc ggt gtg ctc agc ctc cca tac gct gcc cgc 259 Gly Thr Asn Ile Gly Ala Gly Val Leu Ser Leu Pro Tyr Ala Ala Arg          40 45 50 aac ggt ggt ttc ctc gcc ctg gtt gtt gcc ctg ctc att gcg gga aca 307 Asn Gly Gly Phe Leu Ala Leu Val Val Ala Leu Leu Ile Ala Gly Thr      55 60 65 ctg acc acc atc tcc atg ctc tac atc gcc gaa gta tcc ctg cgc acc 355 Leu Thr Thr Ile Ser Met Leu Tyr Ile Ala Glu Val Ser Leu Arg Thr  70 75 80 85 aag aag cca ctg cag ctt tcc ggc ctg gca gaa aaa tac ctg ggg cag 403 Lys Lys Pro Leu Gln Leu Ser Gly Leu Ala Glu Lys Tyr Leu Gly Gln                  90 95 100 tgg ggc cgc tgg ctg gtg ttc att gcc att gtg gtc aac agc gtg ggt 451 Trp Gly Arg Trp Leu Val Phe Ile Ala Ile Val Val Asn Ser Val Gly             105 110 115 gca ctg att gcc tac gca tca gga tcc ggc att ttg ata ggc aac ctc 499 Ala Leu Ile Ala Tyr Ala Ser Gly Ser Gly Ile Leu Ile Gly Asn Leu         120 125 130 acc ggc ctg cca cca atc gtg ggc acc ctt gga ttc ttt gtt tta ggc 547 Thr Gly Leu Pro Pro Ile Val Gly Thr Leu Gly Phe Phe Val Leu Gly     135 140 145 acc ttg atc atg tgg aaa ggc ctg cac acg gca agc ttc gtg gag gca 595 Thr Leu Ile Met Trp Lys Gly Leu His Thr Ala Ser Phe Val Glu Ala 150 155 160 165 ttg atc acc act ggc atg gca acg atc atc atc gtg ctg tgt gga tgg 643 Leu Ile Thr Thr Gly Met Ala Thr Ile Ile Ile Val Leu Cys Gly Trp                 170 175 180 aca gtg ctt ggc cct gga att tcc gca gac aac ctg atc gtg ttc cac 691 Thr Val Leu Gly Pro Gly Ile Ser Ala Asp Asn Leu Ile Val Phe His             185 190 195 cca ttc ttc atc gtt ccg atc atg aac ctc gcg gtc ttt acc ttc ctt 739 Pro Phe Phe Ile Val Pro Ile Met Asn Leu Ala Val Phe Thr Phe Leu         200 205 210 gcc caa tat gtg gtt cca gaa atc gca cga gga gtt aac cct gcc acc 787 Ala Gln Tyr Val Val Pro Glu Ile Ala Arg Gly Val Asn Pro Ala Thr     215 220 225 ccg aag gca gtg cca cgc gcg atc atc atc ggc atg gtc gca act ggt 835 Pro Lys Ala Val Pro Arg Ala Ile Ile Ile Gly Met Val Ala Thr Gly 230 235 240 245 gtc acc ctg gca gct gta cca ttc gcg gca cta ggg ctt ctg ggc aca 883 Val Thr Leu Ala Ala Val Pro Phe Ala Ala Leu Gly Leu Leu Gly Thr                 250 255 260 ggc gtc agt gaa gtt gtc acc atc tcc tgg ggc gaa gca ctc gcc cca 931 Gly Val Ser Glu Val Val Thr Ile Ser Trp Gly Glu Ala Leu Ala Pro             265 270 275 gtg gcc tat tac atg gcc aat gcc ttc gca cta ttg gcc atg ttc act 979 Val Ala Tyr Tyr Met Ala Asn Ala Phe Ala Leu Leu Ala Met Phe Thr         280 285 290 tca ttc atc gcc att gga ttc acc gcg atg cgc aac gta cta gat att 1027 Ser Phe Ile Ala Ile Gly Phe Thr Ala Met Arg Asn Val Leu Asp Ile     295 300 305 ggc cac tgg cca caa cac gga tgg cag cga tcc gtt gct gtc gga cta 1075 Gly His Trp Pro Gln His Gly Trp Gln Arg Ser Val Ala Val Gly Leu 310 315 320 325 act gtt ctt cca cca ctg gca att tca ctt gcg gga tta ggc gga ttc 1123 Thr Val Leu Pro Pro Leu Ala Ile Ser Leu Ala Gly Leu Gly Gly Phe                 330 335 340 gtg gca gca ctg agc tac gcc gga gga ttt gcc gga gca atc atg tcc 1171 Val Ala Ala Leu Ser Tyr Ala Gly Gly Phe Ala Gly Ala Ile Met Ser             345 350 355 atc atc ccc gtg ctg ttg ctg cgc aac tcc cgc aag agt ggc gac caa 1219 Ile Ile Pro Val Leu Leu Leu Arg Asn Ser Arg Lys Ser Gly Asp Gln         360 365 370 gaa cca gtg tgg aaa gcc acc tgg caa gcg cac ccc atc ttc cag atc 1267 Glu Pro Val Trp Lys Ala Thr Trp Gln Ala His Pro Ile Phe Gln Ile     375 380 385 ctg ttg att gtg gtg tac tcc ctg gcg ttt gtg tac tcg gtt ctc gcg 1315 Leu Leu Ile Val Val Tyr Ser Leu Ala Phe Val Tyr Ser Val Leu Ala 390 395 400 405 atc gtc gga tta atg cct gcg ggt tgg gca tagtcacttc ctgttgtggc 1365 Ile Val Gly Leu Met Pro Ala Gly Trp Ala                 410 415 tgc 1368 <210> 530 <211> 415 <212> PRT <213> Corynebacterium glutamicum <400> 530 Met Thr Thr Glu Ser Ile Val Ala His Asn Ala Ala Gly Thr Ala Pro   1 5 10 15 Gln Asn Val Ser Ser Ala Lys Lys Lys Tyr Leu Ser Val Ala Gln Gly              20 25 30 Val Ala Leu Ile Tyr Gly Thr Asn Ile Gly Ala Gly Val Leu Ser Leu          35 40 45 Pro Tyr Ala Ala Arg Asn Gly Gly Phe Leu Ala Leu Val Val Ala Leu      50 55 60 Leu Ile Ala Gly Thr Leu Thr Thr Ile Ser Met Leu Tyr Ile Ala Glu  65 70 75 80 Val Ser Leu Arg Thr Lys Lys Pro Leu Gln Leu Ser Gly Leu Ala Glu                  85 90 95 Lys Tyr Leu Gly Gln Trp Gly Arg Trp Leu Val Phe Ile Ala Ile Val             100 105 110 Val Asn Ser Val Gly Ala Leu Ile Ala Tyr Ala Ser Gly Ser Gly Ile         115 120 125 Leu Ile Gly Asn Leu Thr Gly Leu Pro Pro Ile Val Gly Thr Leu Gly     130 135 140 Phe Phe Val Leu Gly Thr Leu Ile Met Trp Lys Gly Leu His Thr Ala 145 150 155 160 Ser Phe Val Glu Ala Leu Ile Thr Thr Gly Met Ala Thr Ile Ile Ile                 165 170 175 Val Leu Cys Gly Trp Thr Val Leu Gly Pro Gly Ile Ser Ala Asp Asn             180 185 190 Leu Ile Val Phe His Pro Phe Phe Ile Val Pro Ile Met Asn Leu Ala         195 200 205 Val Phe Thr Phe Leu Ala Gln Tyr Val Val Pro Glu Ile Ala Arg Gly     210 215 220 Val Asn Pro Ala Thr Pro Lys Ala Val Pro Arg Ala Ile Ile Ily Gly 225 230 235 240 Met Val Ala Thr Gly Val Thr Leu Ala Ala Val Pro Phe Ala Ala Leu                 245 250 255 Gly Leu Leu Gly Thr Gly Val Ser Glu Val Val Thr Ile Ser Trp Gly             260 265 270 Glu Ala Leu Ala Pro Val Ala Tyr Tyr Met Ala Asn Ala Phe Ala Leu         275 280 285 Leu Ala Met Phe Thr Ser Phe Ile Ala Ile Gly Phe Thr Ala Met Arg     290 295 300 Asn Val Leu Asp Ile Gly His Trp Pro Gln His Gly Trp Gln Arg Ser 305 310 315 320 Val Ala Val Gly Leu Thr Val Leu Pro Pro Leu Ala Ile Ser Leu Ala                 325 330 335 Gly Leu Gly Gly Phe Val Ala Ala Leu Ser Tyr Ala Gly Gly Phe Ala             340 345 350 Gly Ala Ile Met Ser Ile Ile Pro Val Leu Leu Leu Arg Asn Ser Arg         355 360 365 Lys Ser Gly Asp Gln Glu Pro Val Trp Lys Ala Thr Trp Gln Ala His     370 375 380 Pro Ile Phe Gln Ile Leu Leu Ile Val Val Tyr Ser Leu Ala Phe Val 385 390 395 400 Tyr Ser Val Leu Ala Ile Val Gly Leu Met Pro Ala Gly Trp Ala                 405 410 415 <210> 531 <211> 1452 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1429) <223> RXA02527 <400> 531 attggagcaa tcttttaatc aagttgggaa ttccagcgtt gattgtggtt gccatgtggt 60 ttgcccgcac cctgaagcac tcacggatca agcgtggcgg atg ttt ggc ctg ttc 115                                             Met Phe Gly Leu Phe                                               1 5 atc gcg acg att gtg gcg att att ctc aag cca atg cca atg ggt gcc 163 Ile Ala Thr Ile Val Ala Ile Ile Leu Lys Pro Met Pro Met Gly Ala                  10 15 20 gtg aca att atc ggc atg atc gcc gcg gtg ttg act ggt ttg gtg ccg 211 Val Thr Ile Ile Gly Met Ile Ala Ala Val Leu Thr Gly Leu Val Pro              25 30 35 ttg acg gcg tct tct gat gat ccc ggc gcg gtg tat ggc ctt att ggt 259 Leu Thr Ala Ser Ser Asp Asp Pro Gly Ala Val Tyr Gly Leu Ile Gly          40 45 50 ttc agt aac ggc acc att tgg ctg att gtg atg gcg ttc ctg att tcg 307 Phe Ser Asn Gly Thr Ile Trp Leu Ile Val Met Ala Phe Leu Ile Ser      55 60 65 cgt gga ttc atc aag acg ggg ctt gga cgt cga ata gcg ttg ttc ttt 355 Arg Gly Phe Ile Lys Thr Gly Leu Gly Arg Arg Ile Ala Leu Phe Phe  70 75 80 85 gtg tct aaa gtc ggc gga aaa atg ctg ggt gtg acc tat ggt ttg gcg 403 Val Ser Lys Val Gly Gly Lys Met Leu Gly Val Thr Tyr Gly Leu Ala                  90 95 100 ctc gct gat ttg gtg ttg gct cct gcg att cca tca gca act gcc cga 451 Leu Ala Asp Leu Val Leu Ala Pro Ala Ile Pro Ser Ala Thr Ala Arg             105 110 115 ggt ggt ggc att atg gct ccg att atg aag tcg gtg gca ttg act tat 499 Gly Gly Gly Ile Met Ala Pro Ile Met Lys Ser Val Ala Leu Thr Tyr         120 125 130 gat tcc act cct ggc cca act cgt cgc agg gct ggc gcg ttc ttg gcg 547 Asp Ser Thr Pro Gly Pro Thr Arg Arg Arg Ala Gly Ala Phe Leu Ala     135 140 145 ctg aat gtg gga cag gta aat gcg att acg tgc gcg atg ttt cta act 595 Leu Asn Val Gly Gln Val Asn Ala Ile Thr Cys Ala Met Phe Leu Thr 150 155 160 165 gca atg gca gga aac ccc ttg atc gcc tct ttg gct tcg cag atg gat 643 Ala Met Ala Gly Asn Pro Leu Ile Ala Ser Leu Ala Ser Gln Met Asp                 170 175 180 gtc aat atc acg tgg aca aac tgg gct gtg ggt gcg att gtg cct ggt 691 Val Asn Ile Thr Trp Thr Asn Trp Ala Val Gly Ala Ile Val Pro Gly             185 190 195 ctg gtg gcg ctt att gtg gtg ccg tgg gtg gta tac aag atc tat cca 739 Leu Val Ala Leu Ile Val Val Pro Trp Val Val Tyr Lys Ile Tyr Pro         200 205 210 cct gag ttg aag gac acc cct gag gtc aag aaa atg gct tct gat gag 787 Pro Glu Leu Lys Asp Thr Pro Glu Val Lys Lys Met Ala Ser Asp Glu     215 220 225 ctc aag caa ttg ggt ggg ttt act tat ggt gag aag gtg ctg gcg gga 835 Leu Lys Gln Leu Gly Gly Phe Thr Tyr Gly Glu Lys Val Leu Ala Gly 230 235 240 245 acc ttt gtt gtg ttg ctg ctg ctc tgg aca ggt ggc gat ttg gtc ttg 883 Thr Phe Val Val Leu Leu Leu Leu Trp Thr Gly Gly Asp Leu Val Leu                 250 255 260 gga atc tcg gca act acc acc gct ttc gtt ggc gtc atc atc ttg cta 931 Gly Ile Ser Ala Thr Thr Thr Ala Phe Val Gly Val Ile Ile Leu Leu             265 270 275 gtg gct cac gtg ctg acg tgg gag gac atc att caa gaa aag act gcg 979 Val Ala His Val Leu Thr Trp Glu Asp Ile Ile Gln Glu Lys Thr Ala         280 285 290 tgg gac acc atg gtg tgg ttc gcg gtg cta tac atg atg gca aca gcg 1027 Trp Asp Thr Met Val Trp Phe Ala Val Leu Tyr Met Met Ala Thr Ala     295 300 305 tta tcg cag tac gga ttc atc gca tgg atc tct gag gta att gct tcc 1075 Leu Ser Gln Tyr Gly Phe Ile Ala Trp Ile Ser Glu Val Ile Ala Ser 310 315 320 325 agt ttg ggt ggc atg aac tgg gtc gtt gct ttg gtt gtg ttg gtg ctg 1123 Ser Leu Gly Gly Met Asn Trp Val Val Ala Leu Val Val Leu Val Leu                 330 335 340 att tac ttc ttc agt cac tat ttc ttt gcc tcg gca aca gcg cat att 1171 Ile Tyr Phe Phe Ser His Tyr Phe Phe Ala Ser Ala Thr Ala His Ile             345 350 355 tct gcg atg tac ttg gcc ttc ctg ggt gct gcg att gcg att ggt gca 1219 Ser Ala Met Tyr Leu Ala Phe Leu Gly Ala Ala Ile Ala Ile Gly Ala         360 365 370 ccc ccg ttg atg gcg gcc ctg gtg ttg gcg tac acc tcc aat ttg ttc 1267 Pro Pro Leu Met Ala Ala Leu Val Leu Ala Tyr Thr Ser Asn Leu Phe     375 380 385 tct tca ctc act cag tat tct ggt ggt cct tcg cca aca ttg ttt ggt 1315 Ser Ser Leu Thr Gln Tyr Ser Gly Gly Pro Ser Pro Thr Leu Phe Gly 390 395 400 405 ttg aac tac atc acg gtg ggt gag tgg tgg cgg acc tcg gca att gct 1363 Leu Asn Tyr Ile Thr Val Gly Glu Trp Trp Arg Thr Ser Ala Ile Ala                 410 415 420 ggc gcg gta tcg att aca atc tgg ttg gtt atc ggt ggt ttg tgg atg 1411 Gly Ala Val Ser Ile Thr Ile Trp Leu Val Ile Gly Gly Leu Trp Met             425 430 435 aat gtc atc gga ctc tgg taatcgaaaa ttaaaggtaa ggg 1452 Asn Val Ile Gly Leu Trp         440 <210> 532 <211> 443 <212> PRT <213> Corynebacterium glutamicum <400> 532 Met Phe Gly Leu Phe Ile Ala Thr Ile Val Ala Ile Ile Leu Lys Pro   1 5 10 15 Met Pro Met Gly Ala Val Thr Ile Ile Gly Met Ile Ala Ala Val Leu              20 25 30 Thr Gly Leu Val Pro Leu Thr Ala Ser Ser Asp Asp Pro Gly Ala Val          35 40 45 Tyr Gly Leu Ile Gly Phe Ser Asn Gly Thr Ile Trp Leu Ile Val Met      50 55 60 Ala Phe Leu Ile Ser Arg Gly Phe Ile Lys Thr Gly Leu Gly Arg Arg  65 70 75 80 Ile Ala Leu Phe Phe Val Ser Lys Val Gly Gly Lys Met Leu Gly Val                  85 90 95 Thr Tyr Gly Leu Ala Leu Ala Asp Leu Val Leu Ala Pro Ala Ile Pro             100 105 110 Ser Ala Thr Ala Arg Gly Gly Gly Ile Met Ala Pro Ile Met Lys Ser         115 120 125 Val Ala Leu Thr Tyr Asp Ser Thr Pro Gly Pro Thr Arg Arg Arg Ala     130 135 140 Gly Ala Phe Leu Ala Leu Asn Val Gly Gln Val Asn Ala Ile Thr Cys 145 150 155 160 Ala Met Phe Leu Thr Ala Met Ala Gly Asn Pro Leu Ile Ala Ser Leu                 165 170 175 Ala Ser Gln Met Asp Val Asn Ile Thr Trp Thr Asn Trp Ala Val Gly             180 185 190 Ala Ile Val Pro Gly Leu Val Ala Leu Ile Val Val Pro Trp Val Val         195 200 205 Tyr Lys Ile Tyr Pro Pro Glu Leu Lys Asp Thr Pro Glu Val Lys Lys     210 215 220 Met Ala Ser Asp Glu Leu Lys Gln Leu Gly Gly Phe Thr Tyr Gly Glu 225 230 235 240 Lys Val Leu Ala Gly Thr Phe Val Val Leu Leu Leu Leu Trp Thr Gly                 245 250 255 Gly Asp Leu Val Leu Gly Ile Ser Ala Thr Thr Thr Ala Phe Val Gly             260 265 270 Val Ile Ile Leu Leu Val Ala His Val Leu Thr Trp Glu Asp Ile Ile         275 280 285 Gln Glu Lys Thr Ala Trp Asp Thr Met Val Trp Phe Ala Val Leu Tyr     290 295 300 Met Met Ala Thr Ala Leu Ser Gln Tyr Gly Phe Ile Ala Trp Ile Ser 305 310 315 320 Glu Val Ile Ala Ser Ser Leu Gly Gly Met Asn Trp Val Val Ala Leu                 325 330 335 Val Val Leu Val Leu Ile Tyr Phe Phe Ser His Tyr Phe Phe Ala Ser             340 345 350 Ala Thr Ala His Ile Ser Ala Met Tyr Leu Ala Phe Leu Gly Ala Ala         355 360 365 Ile Ala Ile Gly Ala Pro Pro Leu Met Ala Ala Leu Val Leu Ala Tyr     370 375 380 Thr Ser Asn Leu Phe Ser Ser Leu Thr Gln Tyr Ser Gly Gly Pro Ser 385 390 395 400 Pro Thr Leu Phe Gly Leu Asn Tyr Ile Thr Val Gly Glu Trp Trp Arg                 405 410 415 Thr Ser Ala Ile Ala Gly Ala Val Ser Ile Thr Ile Trp Leu Val Ile             420 425 430 Gly Gly Leu Trp Met Asn Val Ile Gly Leu Trp         435 440 <210> 533 <211> 1968 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1945) <223> RXN00298 <400> 533 tttagacaag ttctggttaa aattcttcat gaaggtgaga atctgggaat ttctcggtac 60 tctttcagat tcgtagttat ccactgattg gaagaatgag atg agc tca aat ata 115                                             Met Ser Ser Asn Ile                                               1 5 gct atc acg acc gag cct gaa ggg aaa aat aaa aag ggt ctc aaa tca 163 Ala Ile Thr Thr Glu Pro Glu Gly Lys Asn Lys Lys Gly Leu Lys Ser                  10 15 20 gac ccg ttc att ttt tcc att tct gtc ggt ttt atc gtg gtg ttt gtc 211 Asp Pro Phe Ile Phe Ser Ile Ser Val Gly Phe Ile Val Val Phe Val              25 30 35 atc gcc aca att gcg cta ggc gag aaa gct cga aca acc ttt tcc gcg 259 Ile Ala Thr Ile Ala Leu Gly Glu Lys Ala Arg Thr Thr Phe Ser Ala          40 45 50 att gcc ggc tgg ctc tta gaa aat tta ggg tgg atg tat atc ggg ggt 307 Ile Ala Gly Trp Leu Leu Glu Asn Leu Gly Trp Met Tyr Ile Gly Gly      55 60 65 gtc tcc ttg gtt ttc att ttc ctc atg ggt atc ttt gcg tcc cgg tat 355 Val Ser Leu Val Phe Ile Phe Leu Met Gly Ile Phe Ala Ser Arg Tyr  70 75 80 85 ggc cgg gta aaa ctt ggt gat gac gat gat gac ccc gag cac acc cta 403 Gly Arg Val Lys Leu Gly Asp Asp Asp Asp Asp Pro Glu His Thr Leu                  90 95 100 atc gtg tgg ttc tgt atg ctt ttt gct ggc ggt gtc ggt gca gtc tta 451 Ile Val Trp Phe Cys Met Leu Phe Ala Gly Gly Val Gly Ala Val Leu             105 110 115 atg ttt tgg ggt gtt gcc gaa ccg att aac cac gcg ttc aac gtg cca 499 Met Phe Trp Gly Val Ala Glu Pro Ile Asn His Ala Phe Asn Val Pro         120 125 130 atg gct aat gaa gaa tcc atg agt gaa gcc gca att gtg cag gct ttt 547 Met Ala Asn Glu Glu Ser Met Ser Glu Ala Ala Ile Val Gln Ala Phe     135 140 145 gct tat act ttc tat cac ttc ggt att cac atg tgg gta atc atg gca 595 Ala Tyr Thr Phe Tyr His Phe Gly Ile His Met Trp Val Ile Met Ala 150 155 160 165 ctc cca gga tta tca ttg gga tac ttt att tac aaa cgt aag cta cct 643 Leu Pro Gly Leu Ser Leu Gly Tyr Phe Ile Tyr Lys Arg Lys Leu Pro                 170 175 180 ccc cgt cta tcc tct gtg ttt tct ccg atc ttg ggt aag cac att tat 691 Pro Arg Leu Ser Ser Val Phe Ser Pro Ile Leu Gly Lys His Ile Tyr             185 190 195 tcc aca ccc ggc aag ctc atc gat gta ctg gcc atc gta ggc acc acg 739 Ser Thr Pro Gly Lys Leu Ile Asp Val Leu Ala Ile Val Gly Thr Thr         200 205 210 ttt ggt att gct gtg tca gta ggt ctt ggt gtg ctg caa atc aat gca 787 Phe Gly Ile Ala Val Ser Val Gly Leu Gly Val Leu Gln Ile Asn Ala     215 220 225 ggt atg aac aaa cta tgg agc acc ccg caa gta tcg tgg gtt cag ctt 835 Gly Met Asn Lys Leu Trp Ser Thr Pro Gln Val Ser Trp Val Gln Leu 230 235 240 245 ttg atc atc ttg atc atc acc gcg gtt gca tgt att tcc gtt gct tcc 883 Leu Ile Ile Leu Ile Ile Thr Ala Val Ala Cys Ile Ser Val Ala Ser                 250 255 260 ggt ttg gat aag ggc att aag tta ctg tcc aac att aat att gca atg 931 Gly Leu Asp Lys Gly Ile Lys Leu Leu Ser Asn Ile Asn Ile Ala Met             265 270 275 gcc gtt gcg ttg atg ttc ttc atc ttg ttc act ggt cca acc ctc aca 979 Ala Val Ala Leu Met Phe Phe Ile Leu Phe Thr Gly Pro Thr Leu Thr         280 285 290 ttg ctg cgc ttt ctc gta gaa tcc ttc gga atc tat gca tcc tgg atg 1027 Leu Leu Arg Phe Leu Val Glu Ser Phe Gly Ile Tyr Ala Ser Trp Met     295 300 305 cct aat ctg atg ttt tgg act gac tct ttc caa gat aac cca ggc tgg 1075 Pro Asn Leu Met Phe Trp Thr Asp Ser Phe Gln Asp Asn Pro Gly Trp 310 315 320 325 cag ggc aaa tgg acg gtg ttc tat tgg gca tgg act att tgt tgg tcg 1123 Gln Gly Lys Trp Thr Val Phe Tyr Trp Ala Trp Thr Ile Cys Trp Ser                 330 335 340 cca tat gtc ggc atg ttc gtg gcg cgt att tcg cgt gga cgt acc gtc 1171 Pro Tyr Val Gly Met Phe Val Ala Arg Ile Ser Arg Gly Arg Thr Val             345 350 355 cgt gaa ttt atc ggt ggg gtt cta gct ctg cca gcg atc ttt ggc gta 1219 Arg Glu Phe Ile Gly Gly Val Leu Ala Leu Pro Ala Ile Phe Gly Val         360 365 370 gtt tgg ttc tct atc ttt ggt cgt gca ggc atc gaa gtg gaa ctg agt 1267 Val Trp Phe Ser Ile Phe Gly Arg Ala Gly Ile Glu Val Glu Leu Ser     375 380 385 aac cca ggt ttc ttg acc cag cca act gtt gtt gaa ggt gac gtg cca 1315 Asn Pro Gly Phe Leu Thr Gln Pro Thr Val Val Glu Gly Asp Val Pro 390 395 400 405 gca gcg ctt ttt aat gtg ctg caa gag tat ccg ctg act gga att gtc 1363 Ala Ala Leu Phe Asn Val Leu Gln Glu Tyr Pro Leu Thr Gly Ile Val                 410 415 420 tcc gcg ttt gca ctt gta att att gtg att ttc ttt atc acc tcc atc 1411 Ser Ala Phe Ala Leu Val Ile Ile Val Ile Phe Phe Ile Thr Ser Ile             425 430 435 gat tcc gca gcg cta gtt aac gat atg ttc gct acc ggt gca gaa aat 1459 Asp Ser Ala Ala Leu Val Asn Asp Met Phe Ala Thr Gly Ala Glu Asn         440 445 450 caa aca ccg act agt tac cgc gtg atg tgg gcc tgc acc att ggg gcg 1507 Gln Thr Pro Thr Ser Tyr Arg Val Met Trp Ala Cys Thr Ile Gly Ala     455 460 465 gtc gca ggt tcc ttg ctg atc att tcc cca tcc tct ggt att gcc acg 1555 Val Ala Gly Ser Leu Leu Ile Ile Ser Pro Ser Ser Gly Ile Ala Thr 470 475 480 485 ctg caa gaa gtg gtt atc atc gtg gct ttc cca ttc ttc ctc gtg caa 1603 Leu Gln Glu Val Val Ile Ile Val Ala Phe Pro Phe Phe Leu Val Gln                 490 495 500 ttt gtc atg atg ttt tct ttg ctt aaa ggc atg agt gaa gat gct gct 1651 Phe Val Met Met Phe Ser Leu Leu Lys Gly Met Ser Glu Asp Ala Ala             505 510 515 gcg gtt cgt cgt gtg cag act cgt cag tgg gaa aag act gat aca cca 1699 Ala Val Arg Arg Val Gln Thr Arg Gln Trp Glu Lys Thr Asp Thr Pro         520 525 530 gaa aaa ctt gaa gag cat tcg tcc caa cca gcc ccg ggc tat gat gac 1747 Glu Lys Leu Glu Glu His Ser Ser Gln Pro Ala Pro Gly Tyr Asp Asp     535 540 545 gag ggc aac ccc ttg cca atg cct gcc ctc gaa cat gat gag gac ggt 1795 Glu Gly Asn Pro Leu Pro Met Pro Ala Leu Glu His Asp Glu Asp Gly 550 555 560 565 aac att gtt atc cca ggc aac gta gtc att gaa ggt gat ctt ggg gta 1843 Asn Ile Val Ile Pro Gly Asn Val Val Ile Glu Gly Asp Leu Gly Val                 570 575 580 gtt ggt gat gtg gtc gac gat cct gag gaa gcc caa gag atg ggg tct 1891 Val Gly Asp Val Val Asp Asp Pro Glu Glu Ala Gln Glu Met Gly Ser             585 590 595 cgt ttt aag atc gtc gag caa act cgg ccc cag tcc agg gac gaa tac 1939 Arg Phe Lys Ile Val Glu Gln Thr Arg Pro Gln Ser Arg Asp Glu Tyr         600 605 610 gat att taaacgattg cttttcgacg cac 1968 Asp ile     615 <210> 534 <211> 615 <212> PRT <213> Corynebacterium glutamicum <400> 534 Met Ser Ser Asn Ile Ala Ile Thr Thr Glu Pro Glu Gly Lys Asn Lys   1 5 10 15 Lys Gly Leu Lys Ser Asp Pro Phe Ile Phe Ser Ile Ser Val Gly Phe              20 25 30 Ile Val Val Phe Val Ile Ala Thr Ile Ala Leu Gly Glu Lys Ala Arg          35 40 45 Thr Thr Phe Ser Ala Ile Ala Gly Trp Leu Leu Glu Asn Leu Gly Trp      50 55 60 Met Tyr Ile Gly Gly Val Ser Leu Val Phe Ile Phe Leu Met Gly Ile  65 70 75 80 Phe Ala Ser Arg Tyr Gly Arg Val Lys Leu Gly Asp Asp Asp Asp Asp                  85 90 95 Pro Glu His Thr Leu Ile Val Trp Phe Cys Met Leu Phe Ala Gly Gly             100 105 110 Val Gly Ala Val Leu Met Phe Trp Gly Val Ala Glu Pro Ile Asn His         115 120 125 Ala Phe Asn Val Pro Met Ala Asn Glu Glu Ser Met Ser Glu Ala Ala     130 135 140 Ile Val Gln Ala Phe Ala Tyr Thr Phe Tyr His Phe Gly Ile His Met 145 150 155 160 Trp Val Ile Met Ala Leu Pro Gly Leu Ser Leu Gly Tyr Phe Ile Tyr                 165 170 175 Lys Arg Lys Leu Pro Pro Arg Leu Ser Ser Val Phe Ser Pro Ile Leu             180 185 190 Gly Lys His Ile Tyr Ser Thr Pro Gly Lys Leu Ile Asp Val Leu Ala         195 200 205 Ile Val Gly Thr Thr Phe Gly Ile Ala Val Ser Val Gly Leu Gly Val     210 215 220 Leu Gln Ile Asn Ala Gly Met Asn Lys Leu Trp Ser Thr Pro Gln Val 225 230 235 240 Ser Trp Val Gln Leu Leu Ile Ile Leu Ile Ile Thr Ala Val Ala Cys                 245 250 255 Ile Ser Val Ala Ser Gly Leu Asp Lys Gly Ile Lys Leu Leu Ser Asn             260 265 270 Ile Asn Ile Ala Met Ala Val Ala Leu Met Phe Phe Ile Leu Phe Thr         275 280 285 Gly Pro Thr Leu Thr Leu Leu Arg Phe Leu Val Glu Ser Phe Gly Ile     290 295 300 Tyr Ala Ser Trp Met Pro Asn Leu Met Phe Trp Thr Asp Ser Phe Gln 305 310 315 320 Asp Asn Pro Gly Trp Gln Gly Lys Trp Thr Val Phe Tyr Trp Ala Trp                 325 330 335 Thr Ile Cys Trp Ser Pro Tyr Val Gly Met Phe Val Ala Arg Ile Ser             340 345 350 Arg Gly Arg Thr Val Arg Glu Phe Ile Gly Gly Val Leu Ala Leu Pro         355 360 365 Ala Ile Phe Gly Val Val Trp Phe Ser Ile Phe Gly Arg Ala Gly Ile     370 375 380 Glu Val Glu Leu Ser Asn Pro Gly Phe Leu Thr Gln Pro Thr Val Val 385 390 395 400 Glu Gly Asp Val Pro Ala Ala Leu Phe Asn Val Leu Gln Glu Tyr Pro                 405 410 415 Leu Thr Gly Ile Val Ser Ala Phe Ala Leu Val Ile Ile Val Ile Phe             420 425 430 Phe Ile Thr Ser Ile Asp Ser Ala Ala Leu Val Asn Asp Met Phe Ala         435 440 445 Thr Gly Ala Glu Asn Gln Thr Pro Thr Ser Tyr Arg Val Met Trp Ala     450 455 460 Cys Thr Ile Gly Ala Val Ala Gly Ser Leu Leu Ile Ile Ser Pro Ser 465 470 475 480 Ser Gly Ile Ala Thr Leu Gln Glu Val Val Ile Ile Val Ala Phe Pro                 485 490 495 Phe Phe Leu Val Gln Phe Val Met Met Phe Ser Leu Leu Lys Gly Met             500 505 510 Ser Glu Asp Ala Ala Ala Val Arg Arg Val Gln Thr Arg Gln Trp Glu         515 520 525 Lys Thr Asp Thr Pro Glu Lys Leu Glu Glu His Ser Ser Gln Pro Ala     530 535 540 Pro Gly Tyr Asp Asp Glu Gly Asn Pro Leu Pro Met Pro Ala Leu Glu 545 550 555 560 His Asp Glu Asp Gly Asn Ile Val Ile Pro Gly Asn Val Val Ile Glu                 565 570 575 Gly Asp Leu Gly Val Val Gly Asp Val Val Asp Asp Pro Glu Glu Ala             580 585 590 Gln Glu Met Gly Ser Arg Phe Lys Ile Val Glu Gln Thr Arg Pro Gln         595 600 605 Ser Arg Asp Glu Tyr Asp Ile     610 615 <210> 535 <211> 1968 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1945) <223> FRXA00298 <400> 535 tttagacaag ttctggttaa aattcttcat gaaggtgaga atctgggaat ttctcggtac 60 tctttcagat tcgtagttat ccactgattg gaagaatgag atg agc tca aat ata 115                                             Met Ser Ser Asn Ile                                               1 5 gct atc acg acc gag cct gaa ggg aaa aat aaa aag ggt ctc aaa tca 163 Ala Ile Thr Thr Glu Pro Glu Gly Lys Asn Lys Lys Gly Leu Lys Ser                  10 15 20 gac ccg ttc att ttt tcc att tct gtc ggt ttt atc gtg gtg ttt gtc 211 Asp Pro Phe Ile Phe Ser Ile Ser Val Gly Phe Ile Val Val Phe Val              25 30 35 atc gcc aca att gcg cta ggc gag aaa gct cga aca acc ttt tcc gcg 259 Ile Ala Thr Ile Ala Leu Gly Glu Lys Ala Arg Thr Thr Phe Ser Ala          40 45 50 att gcc ggc tgg ctc tta gaa aat tta ggg tgg atg tat atc ggg ggt 307 Ile Ala Gly Trp Leu Leu Glu Asn Leu Gly Trp Met Tyr Ile Gly Gly      55 60 65 gtc tcc ttg gtt ttc att ttc ctc atg ggt atc ttt gcg tcc cgg tat 355 Val Ser Leu Val Phe Ile Phe Leu Met Gly Ile Phe Ala Ser Arg Tyr  70 75 80 85 ggc cgg gta aaa ctt ggt gat gac gat gat gac ccc gag cac acc cta 403 Gly Arg Val Lys Leu Gly Asp Asp Asp Asp Asp Pro Glu His Thr Leu                  90 95 100 atc gtg tgg ttc tgt atg ctt ttt gct ggc ggt gtc ggt gca gtc tta 451 Ile Val Trp Phe Cys Met Leu Phe Ala Gly Gly Val Gly Ala Val Leu             105 110 115 atg ttt tgg ggt gtt gcc gaa ccg att aac cac gcg ttc aac gtg cca 499 Met Phe Trp Gly Val Ala Glu Pro Ile Asn His Ala Phe Asn Val Pro         120 125 130 atg gct aat gaa gaa tcc atg agt gaa gcc gca att gtg cag gct ttt 547 Met Ala Asn Glu Glu Ser Met Ser Glu Ala Ala Ile Val Gln Ala Phe     135 140 145 gct tat act ttc tat cac ttc ggt att cac atg tgg gta atc atg gca 595 Ala Tyr Thr Phe Tyr His Phe Gly Ile His Met Trp Val Ile Met Ala 150 155 160 165 ctc cca gga tta tca ttg gga tac ttt att tac aaa cgt aag cta cct 643 Leu Pro Gly Leu Ser Leu Gly Tyr Phe Ile Tyr Lys Arg Lys Leu Pro                 170 175 180 ccc cgt cta tcc tct gtg ttt tct ccg atc ttg ggt aag cac att tat 691 Pro Arg Leu Ser Ser Val Phe Ser Pro Ile Leu Gly Lys His Ile Tyr             185 190 195 tcc aca ccc ggc aag ctc atc gat gta ctg gcc atc gta ggc acc acg 739 Ser Thr Pro Gly Lys Leu Ile Asp Val Leu Ala Ile Val Gly Thr Thr         200 205 210 ttt ggt att gct gtg tca gta ggt ctt ggt gtg ctg caa atc aat gca 787 Phe Gly Ile Ala Val Ser Val Gly Leu Gly Val Leu Gln Ile Asn Ala     215 220 225 ggt atg aac aaa cta tgg agc acc ccg caa gta tcg tgg gtt cag ctt 835 Gly Met Asn Lys Leu Trp Ser Thr Pro Gln Val Ser Trp Val Gln Leu 230 235 240 245 ttg atc atc ttg atc atc acc gcg gtt gca tgt att tcc gtt gct tcc 883 Leu Ile Ile Leu Ile Ile Thr Ala Val Ala Cys Ile Ser Val Ala Ser                 250 255 260 ggt ttg gat aag ggc att aag tta ctg tcc aac att aat att gca atg 931 Gly Leu Asp Lys Gly Ile Lys Leu Leu Ser Asn Ile Asn Ile Ala Met             265 270 275 gcc gtt gcg ttg atg ttc ttc atc ttg ttc act ggt cca acc ctc aca 979 Ala Val Ala Leu Met Phe Phe Ile Leu Phe Thr Gly Pro Thr Leu Thr         280 285 290 ttg ctg cgc ttt ctc gta gaa tcc ttc gga atc tat gca tcc tgg atg 1027 Leu Leu Arg Phe Leu Val Glu Ser Phe Gly Ile Tyr Ala Ser Trp Met     295 300 305 cct aat ctg atg ttt tgg act gac tct ttc caa gat aac cca ggc tgg 1075 Pro Asn Leu Met Phe Trp Thr Asp Ser Phe Gln Asp Asn Pro Gly Trp 310 315 320 325 cag ggc aaa tgg acg gtg ttc tat tgg gca tgg act att tgt tgg tcg 1123 Gln Gly Lys Trp Thr Val Phe Tyr Trp Ala Trp Thr Ile Cys Trp Ser                 330 335 340 cca tat gtc ggc atg ttc gtg gcg cgt att tcg cgt gga cgt acc gtc 1171 Pro Tyr Val Gly Met Phe Val Ala Arg Ile Ser Arg Gly Arg Thr Val             345 350 355 cgt gaa ttt atc ggt ggg gtt cta gct ctg cca gcg atc ttt ggc gta 1219 Arg Glu Phe Ile Gly Gly Val Leu Ala Leu Pro Ala Ile Phe Gly Val         360 365 370 gtt tgg ttc tct atc ttt ggt cgt gca ggc atc gaa gtg gaa ctg agt 1267 Val Trp Phe Ser Ile Phe Gly Arg Ala Gly Ile Glu Val Glu Leu Ser     375 380 385 aac cca ggt ttc ttg acc cag cca act gtt gtt gaa ggt gac gtg cca 1315 Asn Pro Gly Phe Leu Thr Gln Pro Thr Val Val Glu Gly Asp Val Pro 390 395 400 405 gca gcg ctt ttt aat gtg ctg caa gag tat ccg ctg act gga att gtc 1363 Ala Ala Leu Phe Asn Val Leu Gln Glu Tyr Pro Leu Thr Gly Ile Val                 410 415 420 tcc gcg ttt gca ctt gta att att gtg att ttc ttt atc acc tcc atc 1411 Ser Ala Phe Ala Leu Val Ile Ile Val Ile Phe Phe Ile Thr Ser Ile             425 430 435 gat tcc gca gcg cta gtt aac gat atg ttc gct acc ggt gca gaa aat 1459 Asp Ser Ala Ala Leu Val Asn Asp Met Phe Ala Thr Gly Ala Glu Asn         440 445 450 caa aca ccg act agt tac cgc gtg atg tgg gcc tgc acc att ggg gcg 1507 Gln Thr Pro Thr Ser Tyr Arg Val Met Trp Ala Cys Thr Ile Gly Ala     455 460 465 gtc gca ggt tcc ttg ctg atc att tcc cca tcc tct ggt att gcc acg 1555 Val Ala Gly Ser Leu Leu Ile Ile Ser Pro Ser Ser Gly Ile Ala Thr 470 475 480 485 ctg caa gaa gtg gtt atc atc gtg gct ttc cca ttc ttc ctc gtg caa 1603 Leu Gln Glu Val Val Ile Ile Val Ala Phe Pro Phe Phe Leu Val Gln                 490 495 500 ttt gtc atg atg ttt tct ttg ctt aaa ggc atg agt gaa gat gct gct 1651 Phe Val Met Met Phe Ser Leu Leu Lys Gly Met Ser Glu Asp Ala Ala             505 510 515 gcg gtt cgt cgt gtg cag act cgt cag tgg gaa aag act gat aca cca 1699 Ala Val Arg Arg Val Gln Thr Arg Gln Trp Glu Lys Thr Asp Thr Pro         520 525 530 gaa aaa ctt gaa gag cat tcg tcc caa cca gcc ccg ggc tat gat gac 1747 Glu Lys Leu Glu Glu His Ser Ser Gln Pro Ala Pro Gly Tyr Asp Asp     535 540 545 gag ggc aac ccc ttg cca atg cct gcc ctc gaa cat gat gag gac ggt 1795 Glu Gly Asn Pro Leu Pro Met Pro Ala Leu Glu His Asp Glu Asp Gly 550 555 560 565 aac att gtt atc cca ggc aac gta gtc att gaa ggt gat ctt ggg gta 1843 Asn Ile Val Ile Pro Gly Asn Val Val Ile Glu Gly Asp Leu Gly Val                 570 575 580 gtt ggt gat gtg gtc gac gat cct gag gaa gcc caa gag atg ggg tct 1891 Val Gly Asp Val Val Asp Asp Pro Glu Glu Ala Gln Glu Met Gly Ser             585 590 595 cgt ttt aag atc gtc gag caa act cgg ccc cag tcc agg gac gaa tac 1939 Arg Phe Lys Ile Val Glu Gln Thr Arg Pro Gln Ser Arg Asp Glu Tyr         600 605 610 gat att taaacgattg cttttcgacg cac 1968 Asp ile     615 <210> 536 <211> 615 <212> PRT <213> Corynebacterium glutamicum <400> 536 Met Ser Ser Asn Ile Ala Ile Thr Thr Glu Pro Glu Gly Lys Asn Lys   1 5 10 15 Lys Gly Leu Lys Ser Asp Pro Phe Ile Phe Ser Ile Ser Val Gly Phe              20 25 30 Ile Val Val Phe Val Ile Ala Thr Ile Ala Leu Gly Glu Lys Ala Arg          35 40 45 Thr Thr Phe Ser Ala Ile Ala Gly Trp Leu Leu Glu Asn Leu Gly Trp      50 55 60 Met Tyr Ile Gly Gly Val Ser Leu Val Phe Ile Phe Leu Met Gly Ile  65 70 75 80 Phe Ala Ser Arg Tyr Gly Arg Val Lys Leu Gly Asp Asp Asp Asp Asp                  85 90 95 Pro Glu His Thr Leu Ile Val Trp Phe Cys Met Leu Phe Ala Gly Gly             100 105 110 Val Gly Ala Val Leu Met Phe Trp Gly Val Ala Glu Pro Ile Asn His         115 120 125 Ala Phe Asn Val Pro Met Ala Asn Glu Glu Ser Met Ser Glu Ala Ala     130 135 140 Ile Val Gln Ala Phe Ala Tyr Thr Phe Tyr His Phe Gly Ile His Met 145 150 155 160 Trp Val Ile Met Ala Leu Pro Gly Leu Ser Leu Gly Tyr Phe Ile Tyr                 165 170 175 Lys Arg Lys Leu Pro Pro Arg Leu Ser Ser Val Phe Ser Pro Ile Leu             180 185 190 Gly Lys His Ile Tyr Ser Thr Pro Gly Lys Leu Ile Asp Val Leu Ala         195 200 205 Ile Val Gly Thr Thr Phe Gly Ile Ala Val Ser Val Gly Leu Gly Val     210 215 220 Leu Gln Ile Asn Ala Gly Met Asn Lys Leu Trp Ser Thr Pro Gln Val 225 230 235 240 Ser Trp Val Gln Leu Leu Ile Ile Leu Ile Ile Thr Ala Val Ala Cys                 245 250 255 Ile Ser Val Ala Ser Gly Leu Asp Lys Gly Ile Lys Leu Leu Ser Asn             260 265 270 Ile Asn Ile Ala Met Ala Val Ala Leu Met Phe Phe Ile Leu Phe Thr         275 280 285 Gly Pro Thr Leu Thr Leu Leu Arg Phe Leu Val Glu Ser Phe Gly Ile     290 295 300 Tyr Ala Ser Trp Met Pro Asn Leu Met Phe Trp Thr Asp Ser Phe Gln 305 310 315 320 Asp Asn Pro Gly Trp Gln Gly Lys Trp Thr Val Phe Tyr Trp Ala Trp                 325 330 335 Thr Ile Cys Trp Ser Pro Tyr Val Gly Met Phe Val Ala Arg Ile Ser             340 345 350 Arg Gly Arg Thr Val Arg Glu Phe Ile Gly Gly Val Leu Ala Leu Pro         355 360 365 Ala Ile Phe Gly Val Val Trp Phe Ser Ile Phe Gly Arg Ala Gly Ile     370 375 380 Glu Val Glu Leu Ser Asn Pro Gly Phe Leu Thr Gln Pro Thr Val Val 385 390 395 400 Glu Gly Asp Val Pro Ala Ala Leu Phe Asn Val Leu Gln Glu Tyr Pro                 405 410 415 Leu Thr Gly Ile Val Ser Ala Phe Ala Leu Val Ile Ile Val Ile Phe             420 425 430 Phe Ile Thr Ser Ile Asp Ser Ala Ala Leu Val Asn Asp Met Phe Ala         435 440 445 Thr Gly Ala Glu Asn Gln Thr Pro Thr Ser Tyr Arg Val Met Trp Ala     450 455 460 Cys Thr Ile Gly Ala Val Ala Gly Ser Leu Leu Ile Ile Ser Pro Ser 465 470 475 480 Ser Gly Ile Ala Thr Leu Gln Glu Val Val Ile Ile Val Ala Phe Pro                 485 490 495 Phe Phe Leu Val Gln Phe Val Met Met Phe Ser Leu Leu Lys Gly Met             500 505 510 Ser Glu Asp Ala Ala Ala Val Arg Arg Val Gln Thr Arg Gln Trp Glu         515 520 525 Lys Thr Asp Thr Pro Glu Lys Leu Glu Glu His Ser Ser Gln Pro Ala     530 535 540 Pro Gly Tyr Asp Asp Glu Gly Asn Pro Leu Pro Met Pro Ala Leu Glu 545 550 555 560 His Asp Glu Asp Gly Asn Ile Val Ile Pro Gly Asn Val Val Ile Glu                 565 570 575 Gly Asp Leu Gly Val Val Gly Asp Val Val Asp Asp Pro Glu Glu Ala             580 585 590 Gln Glu Met Gly Ser Arg Phe Lys Ile Val Glu Gln Thr Arg Pro Gln         595 600 605 Ser Arg Asp Glu Tyr Asp Ile     610 615 <210> 537 <211> 576 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (101) .. (553) <223> RXA00596 <400> 537 ccgccaccga cggcctcttg aacaccgatg cataccaaca ggctgtgctc ggtgaaaatg 60 ccatcggagt gccaagccct agctaccagg gaggaaacta atg ctt aac gcc ctg 115                                             Met Leu Asn Ala Leu                                               1 5 aaa ttc atc cca tgg ctg atc ggc cag att ttc ctc tct ggc ttc agc 163 Lys Phe Ile Pro Trp Leu Ile Gly Gln Ile Phe Leu Ser Gly Phe Ser                  10 15 20 gtg atc acc gct gcg gta aaa aag gac acc ggc ttc aac ccc gtt gtt 211 Val Ile Thr Ala Ala Val Lys Lys Asp Thr Gly Phe Asn Pro Val Val              25 30 35 atc cgc tac cca ctt cga gtg acc acg gac ttc cag atc gca gcc ctg 259 Ile Arg Tyr Pro Leu Arg Val Thr Thr Asp Phe Gln Ile Ala Ala Leu          40 45 50 tca acg tgc atc acc gcg act cct tcc acc ctg tcc ctt ggc cta cgc 307 Ser Thr Cys Ile Thr Ala Thr Pro Ser Thr Leu Ser Leu Gly Leu Arg      55 60 65 gaa ccc cgc aag ccc ggc gac ccc acc att ttg ctg atc caa gca gtg 355 Glu Pro Arg Lys Pro Gly Asp Pro Thr Ile Leu Leu Ile Gln Ala Val  70 75 80 85 ttt ggt tcc gat cca gta gaa gtt ttt gaa tcc atc gcc gat atg gaa 403 Phe Gly Ser Asp Pro Val Glu Val Phe Glu Ser Ile Ala Asp Met Glu                  90 95 100 caa cgc ctc gtc cct tcg gtc gct tca att gac cac ggc gtc cca ggc 451 Gln Arg Leu Val Pro Ser Val Ala Ser Ile Asp His Gly Val Pro Gly             105 110 115 caa ggc cct tac aag gag atc cgc ccc agc gat gct gag tgg cca agt 499 Gln Gly Pro Tyr Lys Glu Ile Arg Pro Ser Asp Ala Glu Trp Pro Ser         120 125 130 cgc gag atc gct gac acc gcc caa aac acc gtc agc caa gac aag agg 547 Arg Glu Ile Ala Asp Thr Ala Gln Asn Thr Val Ser Gln Asp Lys Arg     135 140 145 gag ttt taaaacaaca tgactgcttt tgg 576 Glu phe 150 <210> 538 <211> 151 <212> PRT <213> Corynebacterium glutamicum <400> 538 Met Leu Asn Ala Leu Lys Phe Ile Pro Trp Leu Ile Gly Gln Ile Phe   1 5 10 15 Leu Ser Gly Phe Ser Val Ile Thr Ala Ala Val Lys Lys Asp Thr Gly              20 25 30 Phe Asn Pro Val Val Ile Arg Tyr Pro Leu Arg Val Thr Thr Asp Phe          35 40 45 Gln Ile Ala Ala Leu Ser Thr Cys Ile Thr Ala Thr Pro Ser Thr Leu      50 55 60 Ser Leu Gly Leu Arg Glu Pro Arg Lys Pro Gly Asp Pro Thr Ile Leu  65 70 75 80 Leu Ile Gln Ala Val Phe Gly Ser Asp Pro Val Glu Val Phe Glu Ser                  85 90 95 Ile Ala Asp Met Glu Gln Arg Leu Val Pro Ser Val Ala Ser Ile Asp             100 105 110 His Gly Val Pro Gly Gln Gly Pro Tyr Lys Glu Ile Arg Pro Ser Asp         115 120 125 Ala Glu Trp Pro Ser Arg Glu Ile Ala Asp Thr Ala Gln Asn Thr Val     130 135 140 Ser Gln Asp Lys Arg Glu Phe 145 150 <210> 539 <211> 750 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (727) <223> RXA02364 <400> 539 gcgaaagtat ctaaggtcgt ttgattggtt tactaccccc gaagtggggg ttattggcag 60 catcgagcac caaatgagcg tgatccggga tcaggatctg atg gag cca ctg ttc 115                                             Met glu pro leu phe                                               1 5 caa agt ctt gcg gaa tcg gac aat att tct gtc att ggt gga ttt acc 163 Gln Ser Leu Ala Glu Ser Asp Asn Ile Ser Val Ile Gly Gly Phe Thr                  10 15 20 caa ggc acc cga aat ctg tac acc act gat gcg ccg gtg aaa aga ccc 211 Gln Gly Thr Arg Asn Leu Tyr Thr Thr Asp Ala Pro Val Lys Arg Pro              25 30 35 gct gac ctg gct gga aag aag att cgc gtc cag gaa tcc gcc atg cac 259 Ala Asp Leu Ala Gly Lys Lys Ile Arg Val Gln Glu Ser Ala Met His          40 45 50 atc cgc atg att gaa ctc atg ggt ggc tcg gca acc ccg ttg act tac 307 Ile Arg Met Ile Glu Leu Met Gly Gly Ser Ala Thr Pro Leu Thr Tyr      55 60 65 ggc gag gta tat acc gcg atg cag tct ggt gtg ctg gat ggc gcg gaa 355 Gly Glu Val Tyr Thr Ala Met Gln Ser Gly Val Leu Asp Gly Ala Glu  70 75 80 85 aat aac gag atc agt tac gtt acc caa aac cac ttc gag gtt gct cgc 403 Asn Asn Glu Ile Ser Tyr Val Thr Gln Asn His Phe Glu Val Ala Arg                  90 95 100 tac aac agc aac acc aat cac ctt gtc ggt ttg gat tac atg gtc atg 451 Tyr Asn Ser Asn Thr Asn His Leu Val Gly Leu Asp Tyr Met Val Met             105 110 115 cga cac gat ctg ctt gac gcc atg agc gag cca gac cgt gaa ttg ttc 499 Arg His Asp Leu Leu Asp Ala Met Ser Glu Pro Asp Arg Glu Leu Phe         120 125 130 ctg gaa gaa tgg gac gcc gcg atg act gag cac acg gat ctg tgg aac 547 Leu Glu Glu Trp Asp Ala Ala Met Thr Glu His Thr Asp Leu Trp Asn     135 140 145 aca gaa act gat gcc gtt att gaa aag gcg aaa gct ggg gga gcg gag 595 Thr Glu Thr Asp Ala Val Ile Glu Lys Ala Lys Ala Gly Gly Ala Glu 150 155 160 165 ttc gtt gag gtg gat gcg caa gca ttt acc gat gca ctg gct ccc atc 643 Phe Val Glu Val Asp Ala Gln Ala Phe Thr Asp Ala Leu Ala Pro Ile                 170 175 180 aaa gac gaa ttc ttg acc tca gaa ttc cag cgt gaa ctc tac gaa gca 691 Lys Asp Glu Phe Leu Thr Ser Glu Phe Gln Arg Glu Leu Tyr Glu Ala             185 190 195 gtg cgc gcc gct gat act tca gga ggt gcg gca tca tgatgaattt 737 Val Arg Ala Ala Asp Thr Ser Gly Gly Ala Ala Ser         200 205 taagtccatc gtg 750 <540> 540 <211> 209 <212> PRT <213> Corynebacterium glutamicum <540> 540 Met Glu Pro Leu Phe Gln Ser Leu Ala Glu Ser Asp Asn Ile Ser Val   1 5 10 15 Ile Gly Gly Phe Thr Gln Gly Thr Arg Asn Leu Tyr Thr Thr Asp Ala              20 25 30 Pro Val Lys Arg Pro Ala Asp Leu Ala Gly Lys Lys Ile Arg Val Gln          35 40 45 Glu Ser Ala Met His Ile Arg Met Ile Glu Leu Met Gly Gly Ser Ala      50 55 60 Thr Pro Leu Thr Tyr Gly Glu Val Tyr Thr Ala Met Gln Ser Gly Val  65 70 75 80 Leu Asp Gly Ala Glu Asn Asn Glu Ile Ser Tyr Val Thr Gln Asn His                  85 90 95 Phe Glu Val Ala Arg Tyr Asn Ser Asn Thr Asn His Leu Val Gly Leu             100 105 110 Asp Tyr Met Val Met Arg His Asp Leu Leu Asp Ala Met Ser Glu Pro         115 120 125 Asp Arg Glu Leu Phe Leu Glu Glu Trp Asp Ala Ala Met Thr Glu His     130 135 140 Thr Asp Leu Trp Asn Thr Glu Thr Asp Ala Val Ile Glu Lys Ala Lys 145 150 155 160 Ala Gly Gly Ala Glu Phe Val Glu Val Asp Ala Gln Ala Phe Thr Asp                 165 170 175 Ala Leu Ala Pro Ile Lys Asp Glu Phe Leu Thr Ser Glu Phe Gln Arg             180 185 190 Glu Leu Tyr Glu Ala Val Arg Ala Ala Asp Thr Ser Gly Gly Ala Ala         195 200 205 Ser <210> 541 <211> 888 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (865) <223> RXN01411 <400> 541 cttatcgacg tccccatccc cctcgccaat gcttcggcga ggggttctat ttattgtgtg 60 tgctagcctt ttcgcaatcg ttcagcccgc cccgacgtca atg ttg gga gtg ggc 115                                             Met Leu Gly Val Gly                                               1 5 tgg cgc att cca ttc ctg atg gcc gtg cca cta ggg ctt atc ggc tgg 163 Trp Arg Ile Pro Phe Leu Met Ala Val Pro Leu Gly Leu Ile Gly Trp                  10 15 20 tgg atc cgc acc ggt gcc cag gaa aat gta cgc ccc gca tcc gaa cgc 211 Trp Ile Arg Thr Gly Ala Gln Glu Asn Val Arg Pro Ala Ser Glu Arg              25 30 35 ccc gaa gct cct att aag cag gca ttg cgt act gag tgg aag atg atg 259 Pro Glu Ala Pro Ile Lys Gln Ala Leu Arg Thr Glu Trp Lys Met Met          40 45 50 ttg cgg gta ggt ggc ttt atc tct tgc acc ggt ctg agc ttc tac att 307 Leu Arg Val Gly Gly Phe Ile Ser Cys Thr Gly Leu Ser Phe Tyr Ile      55 60 65 ttc acc acg tac atg acc act ttc ctg cgc agc acc gtc gga ctg gag 355 Phe Thr Thr Tyr Met Thr Thr Phe Leu Arg Ser Thr Val Gly Leu Glu  70 75 80 85 ggc acg tta gtg ctg gct gga aac atc atc gct ctc agc atg gca gca 403 Gly Thr Leu Val Leu Ala Gly Asn Ile Ile Ala Leu Ser Met Ala Ala                  90 95 100 att gtg gcc cca ttt gtt ggc cgc gca att gat aaa ttc ccc cgc cgg 451 Ile Val Ala Pro Phe Val Gly Arg Ala Ile Asp Lys Phe Pro Arg Arg             105 110 115 aac atc atg gct ttc gct acc tta agc aca gta att atg gcg atc ccg 499 Asn Ile Met Ala Phe Ala Thr Leu Ser Thr Val Ile Met Ala Ile Pro         120 125 130 gcc tac atc att gca ggt caa ggt act ttg act gct tct ttg att gcg 547 Ala Tyr Ile Ile Ala Gly Gln Gly Thr Leu Thr Ala Ser Leu Ile Ala     135 140 145 cag gta atg ctt gga atc ggc gcg gtt acc gct aac tgc gtt acc tca 595 Gln Val Met Leu Gly Ile Gly Ala Val Thr Ala Asn Cys Val Thr Ser 150 155 160 165 gta atg atg gcc gag gtc ttc caa gag gtc acc cgc ggt act tcc gcc 643 Val Met Met Ala Glu Val Phe Gln Glu Val Thr Arg Gly Thr Ser Ala                 170 175 180 ggc att acc tac aac gtc act tac gca atc ttc ggc ggc tcg gct cca 691 Gly Ile Thr Tyr Asn Val Thr Tyr Ala Ile Phe Gly Gly Ser Ala Pro             185 190 195 ttt atc tcc acc gca ttg gtc tcc tgg acc ggc agc ccg ctg gcc cct 739 Phe Ile Ser Thr Ala Leu Val Ser Trp Thr Gly Ser Pro Leu Ala Pro         200 205 210 gcg gta tac atg atc atc att gcg ctc ttc gcc ttc acc gcg tcc cgc 787 Ala Val Tyr Met Ile Ile Ile Ala Leu Phe Ala Phe Thr Ala Ser Arg     215 220 225 ttc att cct gaa acc tcc cca gtt ttt gtc acc gca acc ccg gcc att 835 Phe Ile Pro Glu Thr Ser Pro Val Phe Val Thr Ala Thr Pro Ala Ile 230 235 240 245 aag gca cca aag gtg ctg gtc aac ccg ggt taaaccacgc ttttcgacga 885 Lys Ala Pro Lys Val Leu Val Asn Pro Gly                 250 255 aaa 888 <210> 542 <211> 255 <212> PRT <213> Corynebacterium glutamicum <400> 542 Met Leu Gly Val Gly Trp Arg Ile Pro Phe Leu Met Ala Val Pro Leu   1 5 10 15 Gly Leu Ile Gly Trp Trp Ile Arg Thr Gly Ala Gln Glu Asn Val Arg              20 25 30 Pro Ala Ser Glu Arg Pro Glu Ala Pro Ile Lys Gln Ala Leu Arg Thr          35 40 45 Glu Trp Lys Met Met Leu Arg Val Gly Gly Phe Ile Ser Cys Thr Gly      50 55 60 Leu Ser Phe Tyr Ile Phe Thr Thr Tyr Met Thr Thr Phe Leu Arg Ser  65 70 75 80 Thr Val Gly Leu Glu Gly Thr Leu Val Leu Ala Gly Asn Ile Ile Ala                  85 90 95 Leu Ser Met Ala Ala Ile Val Ala Pro Phe Val Gly Arg Ala Ile Asp             100 105 110 Lys Phe Pro Arg Arg Asn Ile Met Ala Phe Ala Thr Leu Ser Thr Val         115 120 125 Ile Met Ala Ile Pro Ala Tyr Ile Ile Ala Gly Gln Gly Thr Leu Thr     130 135 140 Ala Ser Leu Ile Ala Gln Val Met Leu Gly Ile Gly Ala Val Thr Ala 145 150 155 160 Asn Cys Val Thr Ser Val Met Met Ala Glu Val Phe Gln Glu Val Thr                 165 170 175 Arg Gly Thr Ser Ala Gly Ile Thr Tyr Asn Val Thr Tyr Ala Ile Phe             180 185 190 Gly Gly Ser Ala Pro Phe Ile Ser Thr Ala Leu Val Ser Trp Thr Gly         195 200 205 Ser Pro Leu Ala Pro Ala Val Tyr Met Ile Ile Ile Ala Leu Phe Ala     210 215 220 Phe Thr Ala Ser Arg Phe Ile Pro Glu Thr Ser Pro Val Phe Val Thr 225 230 235 240 Ala Thr Pro Ala Ile Lys Ala Pro Lys Val Leu Val Asn Pro Gly                 245 250 255 <210> 543 <211> 1058 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (1035) <223> RXN00960 <400> 543 atg gct cgg cat tgt tgc agc aat cgc tac gcg tcc acc gtc ttc tcc 48 Met Ala Arg His Cys Cys Ser Asn Arg Tyr Ala Ser Thr Val Phe Ser   1 5 10 15 ggt ctg atc gcc tac gga gca tcc caa gcg ctc tac cca tgg ctg ctg 96 Gly Leu Ile Ala Tyr Gly Ala Ser Gln Ala Leu Tyr Pro Trp Leu Leu              20 25 30 aaa gac cac caa agc gtc acc gaa atc gac ctt gat gca ggt gcc ctc 144 Lys Asp His Gln Ser Val Thr Glu Ile Asp Leu Asp Ala Gly Ala Leu          35 40 45 cag ccc tac ttc aac atc gag atg cca cca cca ttt gaa gtg atg acc 192 Gln Pro Tyr Phe Asn Ile Glu Met Pro Pro Pro Phe Glu Val Met Thr      50 55 60 gca ctg ctg ctg gca ttc tgc ctc ggc ctg ggc atg gct gta att aaa 240 Ala Leu Leu Leu Ala Phe Cys Leu Gly Leu Gly Met Ala Val Ile Lys  65 70 75 80 tca gac acc ctg ttc aag gta acc cgc gaa ctc gag cgc gta gtc atg 288 Ser Asp Thr Leu Phe Lys Val Thr Arg Glu Leu Glu Arg Val Val Met                  85 90 95 aag acc atc acc gcc ttt gtc atc cca ctg ctg cca ctc ttc atc ttc 336 Lys Thr Ile Thr Ala Phe Val Ile Pro Leu Leu Pro Leu Phe Ile Phe             100 105 110 ggc atc ttc ctc ggc atg ggc atg aac ggt ggc ctc ctg gag atc atg 384 Gly Ile Phe Leu Gly Met Gly Met Asn Gly Gly Leu Leu Glu Ile Met         115 120 125 tcc gcc ttt ggc aag gta ctg att ctc gcc gtc gtg gga acc ctg ctc 432 Ser Ala Phe Gly Lys Val Leu Ile Leu Ala Val Val Gly Thr Leu Leu     130 135 140 ttc cta gcc atc cag ttc att atc gct ggt gca gta tcc aag aag aac 480 Phe Leu Ala Ile Gln Phe Ile Ile Ala Gly Ala Val Ser Lys Lys Asn 145 150 155 160 cca tgg aaa ctg ttc aaa aac atg ctc cct gca tac ttc act gca ctg 528 Pro Trp Lys Leu Phe Lys Asn Met Leu Pro Ala Tyr Phe Thr Ala Leu                 165 170 175 ggc act tcc tct tca gcg gca acc atc cca gtg acc tac cag cag acc 576 Gly Thr Ser Ser Ser Ala Ala Thr Ile Pro Val Thr Tyr Gln Gln Thr             180 185 190 ctg aaa aac gat gtt gat gtc aac gtc gca ggc ttt gtt gtc cca ctg 624 Leu Lys Asn Asp Val Asp Val Asn Val Ala Gly Phe Val Val Pro Leu         195 200 205 tgc gcc acc atc cac cta gct gga tcg atg atg aag atc ggc ctc ttc 672 Cys Ala Thr Ile His Leu Ala Gly Ser Met Met Lys Ile Gly Leu Phe     210 215 220 acc ttc gct gtt gtc ttc atg tac gac atg gaa gta ggc gtc ggc ctc 720 Thr Phe Ala Val Val Phe Met Tyr Asp Met Glu Val Gly Val Gly Leu 225 230 235 240 tcc atc gga ttc ctc ctc atg ctg ggc atc acc atg atc gcc gca cca 768 Ser Ile Gly Phe Leu Leu Met Leu Gly Ile Thr Met Ile Ala Ala Pro                 245 250 255 ggc gtt ccc ggc gga gcc atc atg gca gca acc ggc atg ctg gcc tcc 816 Gly Val Pro Gly Gly Ala Ile Met Ala Ala Thr Gly Met Leu Ala Ser             260 265 270 atg ctc gga ttc aac acc gaa caa gtc gcc ctc atg atc gcc gct tac 864 Met Leu Gly Phe Asn Thr Glu Gln Val Ala Leu Met Ile Ala Ala Tyr         275 280 285 atc gcg att gac tcc ttc ggc acc gca gca aac gtc acc ggc gac ggc 912 Ile Ala Ile Asp Ser Phe Gly Thr Ala Ala Asn Val Thr Gly Asp Gly     290 295 300 gca atc gca gtc atc gtg aac aaa ttc gcc aag ggc cag ctg cac acc 960 Ala Ile Ala Val Ile Val Asn Lys Phe Ala Lys Gly Gln Leu His Thr 305 310 315 320 act tcc cca gat gaa atc gaa gaa gac gac cgc gtt gcc ttc gac atc 1008 Thr Ser Pro Asp Glu Ile Glu Glu Asp Asp Arg Val Ala Phe Asp Ile                 325 330 335 act cca tcg gat gtg gaa cat cac aag tagaaacccg cattttctgt 1055 Thr Pro Ser Asp Val Glu His His Lys             340 345 agt 1058 <210> 544 <211> 345 <212> PRT <213> Corynebacterium glutamicum <400> 544 Met Ala Arg His Cys Cys Ser Asn Arg Tyr Ala Ser Thr Val Phe Ser   1 5 10 15 Gly Leu Ile Ala Tyr Gly Ala Ser Gln Ala Leu Tyr Pro Trp Leu Leu              20 25 30 Lys Asp His Gln Ser Val Thr Glu Ile Asp Leu Asp Ala Gly Ala Leu          35 40 45 Gln Pro Tyr Phe Asn Ile Glu Met Pro Pro Pro Phe Glu Val Met Thr      50 55 60 Ala Leu Leu Leu Ala Phe Cys Leu Gly Leu Gly Met Ala Val Ile Lys  65 70 75 80 Ser Asp Thr Leu Phe Lys Val Thr Arg Glu Leu Glu Arg Val Val Met                  85 90 95 Lys Thr Ile Thr Ala Phe Val Ile Pro Leu Leu Pro Leu Phe Ile Phe             100 105 110 Gly Ile Phe Leu Gly Met Gly Met Asn Gly Gly Leu Leu Glu Ile Met         115 120 125 Ser Ala Phe Gly Lys Val Leu Ile Leu Ala Val Val Gly Thr Leu Leu     130 135 140 Phe Leu Ala Ile Gln Phe Ile Ile Ala Gly Ala Val Ser Lys Lys Asn 145 150 155 160 Pro Trp Lys Leu Phe Lys Asn Met Leu Pro Ala Tyr Phe Thr Ala Leu                 165 170 175 Gly Thr Ser Ser Ser Ala Ala Thr Ile Pro Val Thr Tyr Gln Gln Thr             180 185 190 Leu Lys Asn Asp Val Asp Val Asn Val Ala Gly Phe Val Val Pro Leu         195 200 205 Cys Ala Thr Ile His Leu Ala Gly Ser Met Met Lys Ile Gly Leu Phe     210 215 220 Thr Phe Ala Val Val Phe Met Tyr Asp Met Glu Val Gly Val Gly Leu 225 230 235 240 Ser Ile Gly Phe Leu Leu Met Leu Gly Ile Thr Met Ile Ala Ala Pro                 245 250 255 Gly Val Pro Gly Gly Ala Ile Met Ala Ala Thr Gly Met Leu Ala Ser             260 265 270 Met Leu Gly Phe Asn Thr Glu Gln Val Ala Leu Met Ile Ala Ala Tyr         275 280 285 Ile Ala Ile Asp Ser Phe Gly Thr Ala Ala Asn Val Thr Gly Asp Gly     290 295 300 Ala Ile Ala Val Ile Val Asn Lys Phe Ala Lys Gly Gln Leu His Thr 305 310 315 320 Thr Ser Pro Asp Glu Ile Glu Glu Asp Asp Arg Val Ala Phe Asp Ile                 325 330 335 Thr Pro Ser Asp Val Glu His His Lys             340 345 <210> 545 <211> 1118 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (1095) <223> RXN02447 <400> 545 aca gta gtt ccg gtg tac ctc gct gaa ctc gca cca cta gaa atc cgc 48 Thr Val Val Pro Val Tyr Leu Ala Glu Leu Ala Pro Leu Glu Ile Arg   1 5 10 15 ggc tcc ctg acc ggc cga aac gag ctt gct atc gtc acc ggc cag ctg 96 Gly Ser Leu Thr Gly Arg Asn Glu Leu Ala Ile Val Thr Gly Gln Leu              20 25 30 ctt gcc ttc gtg atc aac gcg ctt atc gcc gtc acc cta cac gga gtt 144 Leu Ala Phe Val Ile Asn Ala Leu Ile Ala Val Thr Leu His Gly Val          35 40 45 att gat gga atc tgg cgc atc atg ttc gcc gtc tgt gcc ctc cct gcc 192 Ile Asp Gly Ile Trp Arg Ile Met Phe Ala Val Cys Ala Leu Pro Ala      50 55 60 gtc gcc ctc ttc ctc ggc atg ctg cgg atg ccg gaa tca cca cgc tgg 240 Val Ala Leu Phe Leu Gly Met Leu Arg Met Pro Glu Ser Pro Arg Trp  65 70 75 80 ctg gtc aac cag ggg cgt tac gac gac gcc cgc cgc gtc atg gag acc 288 Leu Val Asn Gln Gly Arg Tyr Asp Asp Ala Arg Arg Val Met Glu Thr                  85 90 95 gtc cgt acc cct gag cgt gcg aaa gcc gaa atg gat gaa atc atc gcg 336 Val Arg Thr Pro Glu Arg Ala Lys Ala Glu Met Asp Glu Ile Ile Ala             100 105 110 gtg cac tct gaa aac aat gcg gca ctt cct ggt gtt aag cag tct tcg 384 Val His Ser Glu Asn Asn Ala Ala Leu Pro Gly Val Lys Gln Ser Ser         115 120 125 ggc cag gct tca ggc cag gtt tct agc aag cac acc cac atg tcc atc 432 Gly Gln Ala Ser Gly Gln Val Ser Ser Lys His Thr His Met Ser Ile     130 135 140 ggc gaa gtc ctc agc aac aaa tgg ctg gtt cgt ctg ctc atc gcc ggc 480 Gly Glu Val Leu Ser Asn Lys Trp Leu Val Arg Leu Leu Ile Ala Gly 145 150 155 160 atc ggt gtt gca gtt gcc cag cag ctc acc ggc atc aac gcc atc atg 528 Ile Gly Val Ala Val Ala Gln Gln Leu Thr Gly Ile Asn Ala Ile Met                 165 170 175 tac tac gga acc cgc gtc ctc gag gaa tcc ggc atg agc gca gaa atg 576 Tyr Tyr Gly Thr Arg Val Leu Glu Glu Ser Gly Met Ser Ala Glu Met             180 185 190 gct gtg gtt gcc aac att gct ttc ggt gcc gtt gcc gtc atc ggt gga 624 Ala Val Val Ala Asn Ile Ala Phe Gly Ala Val Ala Val Ile Gly Gly         195 200 205 ctg atc gca ctg cgc aac atg gac cgc ctg gat cgc cgc acc acc ttc 672 Leu Ile Ala Leu Arg Asn Met Asp Arg Leu Asp Arg Arg Thr Thr Phe     210 215 220 atc atc ggc ctg tca ctg acc acc acc ttc cac ctt ttg atc gca gct 720 Ile Ile Gly Leu Ser Leu Thr Thr Thr Phe His Leu Leu Ile Ala Ala 225 230 235 240 gcc ggc act ctc ctt cca gaa ggt aac tcc att cga cca ttc gcc atc 768 Ala Gly Thr Leu Leu Pro Glu Gly Asn Ser Ile Arg Pro Phe Ala Ile                 245 250 255 atg atc ctt gtt gtt ggg ttc gtg ctc tcc atg cag act ttc ctc aac 816 Met Ile Leu Val Val Gly Phe Val Leu Ser Met Gln Thr Phe Leu Asn             260 265 270 gtt gca gtg tgg gtg tgg ctg gcg gaa atc ttc cca gtc cga atg aag 864 Val Ala Val Trp Val Trp Leu Ala Glu Ile Phe Pro Val Arg Met Lys         275 280 285 ggt atc ggc acc ggt att tcg gta ttc tgc ggt tgg ggc atc aat ggc 912 Gly Ile Gly Thr Gly Ile Ser Val Phe Cys Gly Trp Gly Ile Asn Gly     290 295 300 gtc cta gcg ttg ttc ttc cca gca ctg gtc tcc ggc gtg ggt atc acc 960 Val Leu Ala Leu Phe Phe Pro Ala Leu Val Ser Gly Val Gly Ile Thr 305 310 315 320 ttc tcc ttc ctt atc ttc gca gtc gtc gga gtc att gcc ctg gcg ttc 1008 Phe Ser Phe Leu Ile Phe Ala Val Val Gly Val Ile Ala Leu Ala Phe                 325 330 335 gtc acc aag ttt gtt cct gaa acc cgt ggc cgc tca ctt gaa gaa ctc 1056 Val Thr Lys Phe Val Pro Glu Thr Arg Gly Arg Ser Leu Glu Glu Leu             340 345 350 gat cac gca gca ttc acc ggc cag atc ttc aag aag gct taaaccccct 1105 Asp His Ala Ala Phe Thr Gly Gln Ile Phe Lys Lys Ala         355 360 365 ccgatctctt tgg 1118 <210> 546 <211> 365 <212> PRT <213> Corynebacterium glutamicum <400> 546 Thr Val Val Pro Val Tyr Leu Ala Glu Leu Ala Pro Leu Glu Ile Arg   1 5 10 15 Gly Ser Leu Thr Gly Arg Asn Glu Leu Ala Ile Val Thr Gly Gln Leu              20 25 30 Leu Ala Phe Val Ile Asn Ala Leu Ile Ala Val Thr Leu His Gly Val          35 40 45 Ile Asp Gly Ile Trp Arg Ile Met Phe Ala Val Cys Ala Leu Pro Ala      50 55 60 Val Ala Leu Phe Leu Gly Met Leu Arg Met Pro Glu Ser Pro Arg Trp  65 70 75 80 Leu Val Asn Gln Gly Arg Tyr Asp Asp Ala Arg Arg Val Met Glu Thr                  85 90 95 Val Arg Thr Pro Glu Arg Ala Lys Ala Glu Met Asp Glu Ile Ile Ala             100 105 110 Val His Ser Glu Asn Asn Ala Ala Leu Pro Gly Val Lys Gln Ser Ser         115 120 125 Gly Gln Ala Ser Gly Gln Val Ser Ser Lys His Thr His Met Ser Ile     130 135 140 Gly Glu Val Leu Ser Asn Lys Trp Leu Val Arg Leu Leu Ile Ala Gly 145 150 155 160 Ile Gly Val Ala Val Ala Gln Gln Leu Thr Gly Ile Asn Ala Ile Met                 165 170 175 Tyr Tyr Gly Thr Arg Val Leu Glu Glu Ser Gly Met Ser Ala Glu Met             180 185 190 Ala Val Val Ala Asn Ile Ala Phe Gly Ala Val Ala Val Ile Gly Gly         195 200 205 Leu Ile Ala Leu Arg Asn Met Asp Arg Leu Asp Arg Arg Thr Thr Phe     210 215 220 Ile Ile Gly Leu Ser Leu Thr Thr Thr Phe His Leu Leu Ile Ala Ala 225 230 235 240 Ala Gly Thr Leu Leu Pro Glu Gly Asn Ser Ile Arg Pro Phe Ala Ile                 245 250 255 Met Ile Leu Val Val Gly Phe Val Leu Ser Met Gln Thr Phe Leu Asn             260 265 270 Val Ala Val Trp Val Trp Leu Ala Glu Ile Phe Pro Val Arg Met Lys         275 280 285 Gly Ile Gly Thr Gly Ile Ser Val Phe Cys Gly Trp Gly Ile Asn Gly     290 295 300 Val Leu Ala Leu Phe Phe Pro Ala Leu Val Ser Gly Val Gly Ile Thr 305 310 315 320 Phe Ser Phe Leu Ile Phe Ala Val Val Gly Val Ile Ala Leu Ala Phe                 325 330 335 Val Thr Lys Phe Val Pro Glu Thr Arg Gly Arg Ser Leu Glu Glu Leu             340 345 350 Asp His Ala Ala Phe Thr Gly Gln Ile Phe Lys Lys Ala         355 360 365 <210> 547 <211> 2013 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1990) <223> RXN02395 <400> 547 aaacaggaat atttaactcg acttcttaaa aaagctctat acgtaaatat cttgcccatc 60 cagcaccacc tcattgtggt gcacaatgga gaggacacac atg tcc acc aac tct 115                                             Met Ser Thr Asn Ser                                               1 5 ggc aat aac ttg cct gaa tcc caa gag tca ccc gag gaa cct cat tat 163 Gly Asn Asn Leu Pro Glu Ser Gln Glu Ser Pro Glu Glu Pro His Tyr                  10 15 20 cct cac gac acc cac cca ggc cta gtt cct ggc att tcg gtc gat gct 211 Pro His Asp Thr His Pro Gly Leu Val Pro Gly Ile Ser Val Asp Ala              25 30 35 caa cgc aac aag ttc gga ctc gac aaa acc gtt ttc ggc gtc acc gca 259 Gln Arg Asn Lys Phe Gly Leu Asp Lys Thr Val Phe Gly Val Thr Ala          40 45 50 gca tta att ctg gcg ttc atc gcc tgg ggc att tcc agc cct gat tcg 307 Ala Leu Ile Leu Ala Phe Ile Ala Trp Gly Ile Ser Ser Pro Asp Ser      55 60 65 gtt tct tca gta tcg tcc acg atg ttc agt tgg gct atg acg aat act 355 Val Ser Ser Val Ser Ser Thr Met Phe Ser Trp Ala Met Thr Asn Thr  70 75 80 85 ggt tgg ctc ctc aac ttt gtc atg ctg atc ggc att ggc acc atg ctc 403 Gly Trp Leu Leu Asn Phe Val Met Leu Ile Gly Ile Gly Thr Met Leu                  90 95 100 tac atc gct ttt tcg cgc tac ggc cgc atc aag ctg ggc acg gac gaa 451 Tyr Ile Ala Phe Ser Arg Tyr Gly Arg Ile Lys Leu Gly Thr Asp Glu             105 110 115 gac gaa cca gaa ttc tct cgc ttt tcc tgg att gcg atg atg ttc ggc 499 Asp Glu Pro Glu Phe Ser Arg Phe Ser Trp Ile Ala Met Met Phe Gly         120 125 130 gcc ggc atc ggt gtc ggt atc ttc ttc ttc ggt cct tcc gaa ccg ctg 547 Ala Gly Ile Gly Val Gly Ile Phe Phe Phe Gly Pro Ser Glu Pro Leu     135 140 145 tgg cat tat ctc agt ccc cca cct cac acc gtg gaa gga tct aca cct 595 Trp His Tyr Leu Ser Pro Pro Pro His Thr Val Glu Gly Ser Thr Pro 150 155 160 165 gag tcc ttg cac caa gca ctt gcg cag tcc cac ttc cac tgg ggc tta 643 Glu Ser Leu His Gln Ala Leu Ala Gln Ser His Phe His Trp Gly Leu                 170 175 180 tcc gcc tgg ggg ctg tat gcc ttg gtc ggc ggc gcg ttg gcg tac tcc 691 Ser Ala Trp Gly Leu Tyr Ala Leu Val Gly Gly Ala Leu Ala Tyr Ser             185 190 195 agt tac cga cgc ggc cgc gta acc ttg atc agc tcc acc ttc cgg tca 739 Ser Tyr Arg Arg Gly Arg Val Thr Leu Ile Ser Ser Thr Phe Arg Ser         200 205 210 ctt ttc ggt gag aaa acc gaa ggt atc gcg ggt cgc ctc atc gac atg 787 Leu Phe Gly Glu Lys Thr Glu Gly Ile Ala Gly Arg Leu Ile Asp Met     215 220 225 atg gcg atc atc gcc acg ctg ttt gga acg gct gca acc ttg ggc ctt 835 Met Ala Ile Ile Ala Thr Leu Phe Gly Thr Ala Ala Thr Leu Gly Leu 230 235 240 245 tca gca att cag gtt ggt cag ggc gtg cag att att tct ggc gct tcg 883 Ser Ala Ile Gln Val Gly Gln Gly Val Gln Ile Ile Ser Gly Ala Ser                 250 255 260 gaa atc acc aac aac atc ttg atc gcc atc atc gcg atc ttg acc att 931 Glu Ile Thr Asn Asn Ile Leu Ile Ala Ile Ile Ala Ile Leu Thr Ile             265 270 275 ggc ttc atc atc tcc tca gta tct ggc gtg tcc aag ggc att cgt tat 979 Gly Phe Ile Ile Ser Ser Val Ser Gly Val Ser Lys Gly Ile Arg Tyr         280 285 290 ctt tcc aac ctc aat att tcc ttg acg ctt gga ttg gtc ctg ttt gtg 1027 Leu Ser Asn Leu Asn Ile Ser Leu Thr Leu Gly Leu Val Leu Phe Val     295 300 305 ttc atc acc ggc ccc acc ttg ttc ctg ctc aac ttg atc cca tcg agt 1075 Phe Ile Thr Gly Pro Thr Leu Phe Leu Leu Asn Leu Ile Pro Ser Ser 310 315 320 325 gtg ttg gaa tat ggc agt gag ttc ttg tca atg gct ggc aag tct ttg 1123 Val Leu Glu Tyr Gly Ser Glu Phe Leu Ser Met Ala Gly Lys Ser Leu                 330 335 340 tcg tgg ggt gag gaa acc att gaa ttc caa gct ggt tgg acg gcg ttc 1171 Ser Trp Gly Glu Glu Thr Ile Glu Phe Gln Ala Gly Trp Thr Ala Phe             345 350 355 tac tgg gca tgg tgg atc gca tgg act cca ttc gtg ggt atg ttc atc 1219 Tyr Trp Ala Trp Trp Ile Ala Trp Thr Pro Phe Val Gly Met Phe Ile         360 365 370 gcg cgt att tct cgc ggc cgc acc ttg cgt gaa ttc gcg ctc atc acc 1267 Ala Arg Ile Ser Arg Gly Arg Thr Leu Arg Glu Phe Ala Leu Ile Thr     375 380 385 atg gct atc ccc tcc ttc att ttg atc ctg gcg ttc acc att ttc ggt 1315 Met Ala Ile Pro Ser Phe Ile Leu Ile Leu Ala Phe Thr Ile Phe Gly 390 395 400 405 gga act gcc atc acg atg aac cgc gag aac gta gat ggt ttt gac ggc 1363 Gly Thr Ala Ile Thr Met Asn Arg Glu Asn Val Asp Gly Phe Asp Gly                 410 415 420 agt tca tcc aag gaa cag gtg ctg ttt gat atg ttc agc aac ctt ccg 1411 Ser Ser Ser Lys Glu Gln Val Leu Phe Asp Met Phe Ser Asn Leu Pro             425 430 435 ctg tac tcg atc aca ccg ttc att ttg atc ttt gtg ctg gca gta ttc 1459 Leu Tyr Ser Ile Thr Pro Phe Ile Leu Ile Phe Val Leu Ala Val Phe         440 445 450 ttt gtt acc tct gcc gat tcc gcc tcc gtg gtg atg gga acg atg agc 1507 Phe Val Thr Ser Ala Asp Ser Ala Ser Val Val Met Gly Thr Met Ser     455 460 465 tcc caa ggt aac cct gca cca aac aaa tta atc gtg gtg ttc tgg gga 1555 Ser Gln Gly Asn Pro Ala Pro Asn Lys Leu Ile Val Val Phe Trp Gly 470 475 480 485 ctg tgc atg atg ggc atc gcg gtg gtc atg ctg ctt act ggt ggc gaa 1603 Leu Cys Met Met Gly Ile Ala Val Val Met Leu Leu Thr Gly Gly Glu                 490 495 500 tcc gcg ctg act ggt ctg cag aac ctc acc att ttg atc gcc att ccg 1651 Ser Ala Leu Thr Gly Leu Gln Asn Leu Thr Ile Leu Ile Ala Ile Pro             505 510 515 ttt gcg ctg gtg ttg atc gtg atg gct att gcc ttt att aag gac tta 1699 Phe Ala Leu Val Leu Ile Val Met Ala Ile Ala Phe Ile Lys Asp Leu         520 525 530 tcc aca gac cca gcc gct att cga caa cgc tat gca aag gca gcc atc 1747 Ser Thr Asp Pro Ala Ala Ile Arg Gln Arg Tyr Ala Lys Ala Ala Ile     535 540 545 tct aac gcg gtg gtt cgt ggc ttg gaa gaa cac ggc gac gac ttc gag 1795 Ser Asn Ala Val Val Arg Gly Leu Glu Glu His Gly Asp Asp Phe Glu 550 555 560 565 ctc tcc atc gaa cct gca gag gaa ggt cgt gga gcg ggt gct acc ttc 1843 Leu Ser Ile Glu Pro Ala Glu Glu Gly Arg Gly Ala Gly Ala Thr Phe                 570 575 580 gat tcc acc gct gat cac atc acc gac tgg tat cag cgc acc gac gaa 1891 Asp Ser Thr Ala Asp His Ile Thr Asp Trp Tyr Gln Arg Thr Asp Glu             585 590 595 gaa ggc aat gat gtt gat tat gac ttc acc acc ggc aaa tgg gcc gat 1939 Glu Gly Asn Asp Val Asp Tyr Asp Phe Thr Thr Gly Lys Trp Ala Asp         600 605 610 ggt tgg aca ccg gaa tcg acc gaa gaa ggc gaa gtg gac gcg aaa aag 1987 Gly Trp Thr Pro Glu Ser Thr Glu Glu Gly Glu Val Asp Ala Lys Lys     615 620 625 gat taaaaaataa cgactggctg gga 2013 Asp 630 <210> 548 <211> 630 <212> PRT <213> Corynebacterium glutamicum <400> 548 Met Ser Thr Asn Ser Gly Asn Asn Leu Pro Glu Ser Gln Glu Ser Pro   1 5 10 15 Glu Glu Pro His Tyr Pro His Asp Thr His Pro Gly Leu Val Pro Gly              20 25 30 Ile Ser Val Asp Ala Gln Arg Asn Lys Phe Gly Leu Asp Lys Thr Val          35 40 45 Phe Gly Val Thr Ala Ala Leu Ile Leu Ala Phe Ile Ala Trp Gly Ile      50 55 60 Ser Ser Pro Asp Ser Val Ser Ser Val Ser Ser Thr Met Phe Ser Trp  65 70 75 80 Ala Met Thr Asn Thr Gly Trp Leu Leu Asn Phe Val Met Leu Ile Gly                  85 90 95 Ile Gly Thr Met Leu Tyr Ile Ala Phe Ser Arg Tyr Gly Arg Ile Lys             100 105 110 Leu Gly Thr Asp Glu Asp Glu Pro Glu Phe Ser Arg Phe Ser Trp Ile         115 120 125 Ala Met Met Phe Gly Ala Gly Ile Gly Val Gly Ile Phe Phe Phe Gly     130 135 140 Pro Ser Glu Pro Leu Trp His Tyr Leu Ser Pro Pro Pro His Thr Val 145 150 155 160 Glu Gly Ser Thr Pro Glu Ser Leu His Gln Ala Leu Ala Gln Ser His                 165 170 175 Phe His Trp Gly Leu Ser Ala Trp Gly Leu Tyr Ala Leu Val Gly Gly             180 185 190 Ala Leu Ala Tyr Ser Ser Tyr Arg Arg Gly Arg Val Thr Leu Ile Ser         195 200 205 Ser Thr Phe Arg Ser Leu Phe Gly Glu Lys Thr Glu Gly Ile Ala Gly     210 215 220 Arg Leu Ile Asp Met Met Ala Ile Ile Ala Thr Leu Phe Gly Thr Ala 225 230 235 240 Ala Thr Leu Gly Leu Ser Ala Ile Gln Val Gly Gln Gly Val Gln Ile                 245 250 255 Ile Ser Gly Ala Ser Glu Ile Thr Asn Asn Ile Leu Ile Ala Ile Ile             260 265 270 Ala Ile Leu Thr Ile Gly Phe Ile Ile Ser Ser Val Ser Gly Val Ser         275 280 285 Lys Gly Ile Arg Tyr Leu Ser Asn Leu Asn Ile Ser Leu Thr Leu Gly     290 295 300 Leu Val Leu Phe Val Phe Ile Thr Gly Pro Thr Leu Phe Leu Leu Asn 305 310 315 320 Leu Ile Pro Ser Ser Val Leu Glu Tyr Gly Ser Glu Phe Leu Ser Met                 325 330 335 Ala Gly Lys Ser Leu Ser Trp Gly Glu Glu Thr Ile Glu Phe Gln Ala             340 345 350 Gly Trp Thr Ala Phe Tyr Trp Ala Trp Trp Ile Ala Trp Thr Pro Phe         355 360 365 Val Gly Met Phe Ile Ala Arg Ile Ser Arg Gly Arg Thr Leu Arg Glu     370 375 380 Phe Ala Leu Ile Thr Met Ala Ile Pro Ser Phe Ile Leu Ile Leu Ala 385 390 395 400 Phe Thr Ile Phe Gly Gly Thr Ala Ile Thr Met Asn Arg Glu Asn Val                 405 410 415 Asp Gly Phe Asp Gly Ser Ser Ser Lys Glu Gln Val Leu Phe Asp Met             420 425 430 Phe Ser Asn Leu Pro Leu Tyr Ser Ile Thr Pro Phe Ile Leu Ile Phe         435 440 445 Val Leu Ala Val Phe Phe Val Thr Ser Ala Asp Ser Ala Ser Val Val     450 455 460 Met Gly Thr Met Ser Ser Gln Gly Asn Pro Ala Pro Asn Lys Leu Ile 465 470 475 480 Val Val Phe Trp Gly Leu Cys Met Met Gly Ile Ala Val Val Met Leu                 485 490 495 Leu Thr Gly Gly Glu Ser Ala Leu Thr Gly Leu Gln Asn Leu Thr Ile             500 505 510 Leu Ile Ala Ile Pro Phe Ala Leu Val Leu Ile Val Met Ala Ile Ala         515 520 525 Phe Ile Lys Asp Leu Ser Thr Asp Pro Ala Ala Ile Arg Gln Arg Tyr     530 535 540 Ala Lys Ala Ala Ile Ser Asn Ala Val Val Arg Gly Leu Glu Glu His 545 550 555 560 Gly Asp Asp Phe Glu Leu Ser Ile Glu Pro Ala Glu Glu Gly Arg Gly                 565 570 575 Ala Gly Ala Thr Phe Asp Ser Thr Ala Asp His Ile Thr Asp Trp Tyr             580 585 590 Gln Arg Thr Asp Glu Glu Gly Asn Asp Val Asp Tyr Asp Phe Thr Thr         595 600 605 Gly Lys Trp Ala Asp Gly Trp Thr Pro Glu Ser Thr Glu Glu Gly Glu     610 615 620 Val Asp Ala Lys Lys Asp 625 630 <210> 549 <211> 2007 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1984) <223> RXN02348 <400> 549 aaagacccga gccgaagccc tggcctgcgc atacttcctt gtcaacgctc gctgggatta 60 ggtcttttct gagcgctagc atttctccac tcaaaggagc atg ctt aac cgc atg 115                                             Met Leu Asn Arg Met                                               1 5 aaa agt gcg cgg cca aaa tca gtc gct cca aaa tcc gga caa gct tta 163 Lys Ser Ala Arg Pro Lys Ser Val Ala Pro Lys Ser Gly Gln Ala Leu                  10 15 20 ctc act ctc ggt gcc cta ggt gtt gtg ttc ggc gac atc ggc acc agc 211 Leu Thr Leu Gly Ala Leu Gly Val Val Phe Gly Asp Ile Gly Thr Ser              25 30 35 ccc ctg tac tca ctt cac act gca ttc agc atg cag cac aac aaa gtc 259 Pro Leu Tyr Ser Leu His Thr Ala Phe Ser Met Gln His Asn Lys Val          40 45 50 gaa gtc act cag gaa aat gtg tac ggc atc atc tcc atg gtg ttg tgg 307 Glu Val Thr Gln Glu Asn Val Tyr Gly Ile Ile Ser Met Val Leu Trp      55 60 65 acc atc act ttg atc gtc acc gtc aaa tac gtc atg ctg gtc acc cga 355 Thr Ile Thr Leu Ile Val Thr Val Lys Tyr Val Met Leu Val Thr Arg  70 75 80 85 gct gac aac caa gga caa ggt ggc atc ctg gcg ctc gtt gct ttg ctg 403 Ala Asp Asn Gln Gly Gln Gly Gly Ile Leu Ala Leu Val Ala Leu Leu                  90 95 100 aaa aac cgt ggg cac tgg gga aaa ttc gtg gca gta gcc ggc atg ttg 451 Lys Asn Arg Gly His Trp Gly Lys Phe Val Ala Val Ala Gly Met Leu             105 110 115 ggc gcc gca ttg ttt tat ggc gat gtg gtg atc acc ccg gcg atc tct 499 Gly Ala Ala Leu Phe Tyr Gly Asp Val Val Ile Thr Pro Ala Ile Ser         120 125 130 gtt ctc agc gca aca gaa ggc ttg acg gtt atc tcc cca agc ttt gag 547 Val Leu Ser Ala Thr Glu Gly Leu Thr Val Ile Ser Pro Ser Phe Glu     135 140 145 cgc ttc att ctg ccc gta tct ctc gca gtt ctg atc gct att ttt gca 595 Arg Phe Ile Leu Pro Val Ser Leu Ala Val Leu Ile Ala Ile Phe Ala 150 155 160 165 atc caa ccg ctc ggt aca gaa aaa gtc ggc aaa gcc ttc ggc ccc atc 643 Ile Gln Pro Leu Gly Thr Glu Lys Val Gly Lys Ala Phe Gly Pro Ile                 170 175 180 atg ttg ctg tgg ttt gtc acc ctt gca gga ttg gga att ccg caa atc 691 Met Leu Leu Trp Phe Val Thr Leu Ala Gly Leu Gly Ile Pro Gln Ile             185 190 195 atc ggg cac cca gaa atc ttg cag agc ttg tct cca cat tgg gcc ctg 739 Ile Gly His Pro Glu Ile Leu Gln Ser Leu Ser Pro His Trp Ala Leu         200 205 210 cgc ttg att gtg gct gag cct ttc caa gca ttt gtg ctg ctt ggt gcc 787 Arg Leu Ile Val Ala Glu Pro Phe Gln Ala Phe Val Leu Leu Gly Ala     215 220 225 gtt gtc ctg aca gta acg ggt gcg gaa gcg ctc tac gct gat atg ggc 835 Val Val Leu Thr Val Thr Gly Ala Glu Ala Leu Tyr Ala Asp Met Gly 230 235 240 245 cat ttt ggg gcg agg cca atc aga gtg gcg tgg ttt tgc gtc gtc atg 883 His Phe Gly Ala Arg Pro Ile Arg Val Ala Trp Phe Cys Val Val Met                 250 255 260 cct gct tta atc ttg acg tat ttg ggg cag ggc gcc ttg gtg atc aac 931 Pro Ala Leu Ile Leu Thr Tyr Leu Gly Gln Gly Ala Leu Val Ile Asn             265 270 275 cag cct gaa gcg gtg cgc aac ccc atg ttt tat ctc gcg ccg gaa ggt 979 Gln Pro Glu Ala Val Arg Asn Pro Met Phe Tyr Leu Ala Pro Glu Gly         280 285 290 ctg cgg att ccg ttg gtt att ttg gcg acc atc gct acg gtg atc gca 1027 Leu Arg Ile Pro Leu Val Ile Leu Ala Thr Ile Ala Thr Val Ile Ala     295 300 305 tcg cag gcc gtg att tct ggt gcg tat tca ttg acc aag cag gcc gtg 1075 Ser Gln Ala Val Ile Ser Gly Ala Tyr Ser Leu Thr Lys Gln Ala Val 310 315 320 325 aat ttg aaa ctg ctg cca cgc atg gtg atc cgg cat acc tcc cgc aaa 1123 Asn Leu Lys Leu Leu Pro Arg Met Val Ile Arg His Thr Ser Arg Lys                 330 335 340 gag gaa ggc cag atc tat atg cca ctg gtt aat gga ttg ctg ttt gta 1171 Glu Glu Gly Gln Ile Tyr Met Pro Leu Val Asn Gly Leu Leu Phe Val             345 350 355 tcc gtg atg gtt gtg gtg ctg gta ttc cga tcc tct gaa agc ctc gcc 1219 Ser Val Met Val Val Val Leu Val Phe Arg Ser Ser Glu Ser Leu Ala         360 365 370 agc gcg tac gga ctt gca gtg acc gga acc ttg gtg ctg gtc agc gtc 1267 Ser Ala Tyr Gly Leu Ala Val Thr Gly Thr Leu Val Leu Val Ser Val     375 380 385 ctg tat ctg atc tat gtt cac acc aca tgg tgg aaa aca gcg ctg ttc 1315 Leu Tyr Leu Ile Tyr Val His Thr Thr Trp Trp Lys Thr Ala Leu Phe 390 395 400 405 att gtg ctc atc ggt att cca gaa gta ctt cta ttc gcc tcg aac acc 1363 Ile Val Leu Ile Gly Ile Pro Glu Val Leu Leu Phe Ala Ser Asn Thr                 410 415 420 acg aaa att cac gac ggt ggc tgg ctt cca cta ctt att gcg gcc gtg 1411 Thr Lys Ile His Asp Gly Gly Trp Leu Pro Leu Leu Ile Ala Ala Val             425 430 435 ctc atc gtg gtg atg cgg acc tgg gag tgg gga agt gac cgc gtc aat 1459 Leu Ile Val Val Met Arg Thr Trp Glu Trp Gly Ser Asp Arg Val Asn         440 445 450 cag gaa cgc gca gag ctg gaa ctt ccc atg gat aag ttc ttg gag aaa 1507 Gln Glu Arg Ala Glu Leu Glu Leu Pro Met Asp Lys Phe Leu Glu Lys     455 460 465 ctc gat cag cca cac aat att ggt ctg cgt aaa gtt gcc gaa gtg gca 1555 Leu Asp Gln Pro His Asn Ile Gly Leu Arg Lys Val Ala Glu Val Ala 470 475 480 485 gta ttt cca cat ggc acc agc gat act gtc ccg ttg tca ttg gtt cgc 1603 Val Phe Pro His Gly Thr Ser Asp Thr Val Pro Leu Ser Leu Val Arg                 490 495 500 tgc gtg aaa gac ctc aag ctt tta tac cga gag atc gtg atc gtt cga 1651 Cys Val Lys Asp Leu Lys Leu Leu Tyr Arg Glu Ile Val Ile Val Arg             505 510 515 atc gtc caa gaa cac gtt ccg cac gtg cca cca gag gaa cgc gcg gaa 1699 Ile Val Gln Glu His Val Pro His Val Pro Pro Glu Glu Arg Ala Glu         520 525 530 atg gaa gtg ctc cat cac gcc ccg atc aga gtc gtg cga gtt gat ctg 1747 Met Glu Val Leu His His Ala Pro Ile Arg Val Val Arg Val Asp Leu     535 540 545 cac ctt ggt tat ttt gat gag cag aac ctg cct gag cat ctc cat gcc 1795 His Leu Gly Tyr Phe Asp Glu Gln Asn Leu Pro Glu His Leu His Ala 550 555 560 565 att gac cca aca tgg gat aac gcc acc tac ttc ctg tct gcc ctg act 1843 Ile Asp Pro Thr Trp Asp Asn Ala Thr Tyr Phe Leu Ser Ala Leu Thr                 570 575 580 ctt cgg agc agg ttg cct gga aag att gct ggc tgg cgt gat cgt ttg 1891 Leu Arg Ser Arg Leu Pro Gly Lys Ile Ala Gly Trp Arg Asp Arg Leu             585 590 595 tat ctt tcg atg gaa cgt aat cag gca tct cga act gag tct ttc aaa 1939 Tyr Leu Ser Met Glu Arg Asn Gln Ala Ser Arg Thr Glu Ser Phe Lys         600 605 610 ttg caa cca agc aaa acc atc acg gtt gga aca gag ctg cac ctt 1984 Leu Gln Pro Ser Lys Thr Ile Thr Val Gly Thr Glu Leu His Leu     615 620 625 taatcaggca gttgctggcc aac 2007 <210> 550 <211> 628 <212> PRT <213> Corynebacterium glutamicum <400> 550 Met Leu Asn Arg Met Lys Ser Ala Arg Pro Lys Ser Val Ala Pro Lys   1 5 10 15 Ser Gly Gln Ala Leu Leu Thr Leu Gly Ala Leu Gly Val Val Phe Gly              20 25 30 Asp Ile Gly Thr Ser Pro Leu Tyr Ser Leu His Thr Ala Phe Ser Met          35 40 45 Gln His Asn Lys Val Glu Val Thr Gln Glu Asn Val Tyr Gly Ile Ile      50 55 60 Ser Met Val Leu Trp Thr Ile Thr Leu Ile Val Thr Val Lys Tyr Val  65 70 75 80 Met Leu Val Thr Arg Ala Asp Asn Gln Gly Gln Gly Gly Ile Leu Ala                  85 90 95 Leu Val Ala Leu Leu Lys Asn Arg Gly His Trp Gly Lys Phe Val Ala             100 105 110 Val Ala Gly Met Leu Gly Ala Ala Leu Phe Tyr Gly Asp Val Val Ile         115 120 125 Thr Pro Ala Ile Ser Val Leu Ser Ala Thr Glu Gly Leu Thr Val Ile     130 135 140 Ser Pro Ser Phe Glu Arg Phe Ile Leu Pro Val Ser Leu Ala Val Leu 145 150 155 160 Ile Ala Ile Phe Ala Ile Gln Pro Leu Gly Thr Glu Lys Val Gly Lys                 165 170 175 Ala Phe Gly Pro Ile Met Leu Leu Trp Phe Val Thr Leu Ala Gly Leu             180 185 190 Gly Ile Pro Gln Ile Ile Gly His Pro Glu Ile Leu Gln Ser Leu Ser         195 200 205 Pro His Trp Ala Leu Arg Leu Ile Val Ala Glu Pro Phe Gln Ala Phe     210 215 220 Val Leu Leu Gly Ala Val Val Leu Thr Val Thr Gly Ala Glu Ala Leu 225 230 235 240 Tyr Ala Asp Met Gly His Phe Gly Ala Arg Pro Ile Arg Val Ala Trp                 245 250 255 Phe Cys Val Val Met Pro Ala Leu Ile Leu Thr Tyr Leu Gly Gln Gly             260 265 270 Ala Leu Val Ile Asn Gln Pro Glu Ala Val Arg Asn Pro Met Phe Tyr         275 280 285 Leu Ala Pro Glu Gly Leu Arg Ile Pro Leu Val Ile Leu Ala Thr Ile     290 295 300 Ala Thr Val Ile Ala Ser Gln Ala Val Ile Ser Gly Ala Tyr Ser Leu 305 310 315 320 Thr Lys Gln Ala Val Asn Leu Lys Leu Leu Pro Arg Met Val Ile Arg                 325 330 335 His Thr Ser Arg Lys Glu Glu Gly Gln Ile Tyr Met Pro Leu Val Asn             340 345 350 Gly Leu Leu Phe Val Ser Val Met Val Val Le Leu Val Phe Arg Ser         355 360 365 Ser Glu Ser Leu Ala Ser Ala Tyr Gly Leu Ala Val Thr Gly Thr Leu     370 375 380 Val Leu Val Ser Val Leu Tyr Leu Ile Tyr Val His Thr Thr Trp Trp 385 390 395 400 Lys Thr Ala Leu Phe Ile Val Leu Ile Gly Ile Pro Glu Val Leu Leu                 405 410 415 Phe Ala Ser Asn Thr Thr Lys Ile His Asp Gly Gly Trp Leu Pro Leu             420 425 430 Leu Ile Ala Ala Val Leu Ile Val Val Met Arg Thr Trp Glu Trp Gly         435 440 445 Ser Asp Arg Val Asn Gln Glu Arg Ala Glu Leu Glu Leu Pro Met Asp     450 455 460 Lys Phe Leu Glu Lys Leu Asp Gln Pro His Asn Ile Gly Leu Arg Lys 465 470 475 480 Val Ala Glu Val Ala Val Phe Pro His Gly Thr Ser Asp Thr Val Pro                 485 490 495 Leu Ser Leu Val Arg Cys Val Lys Asp Leu Lys Leu Leu Tyr Arg Glu             500 505 510 Ile Val Ile Val Arg Ile Val Gln Glu His Val Pro His Val Pro Pro         515 520 525 Glu Glu Arg Ala Glu Met Glu Val Leu His His Ala Pro Ile Arg Val     530 535 540 Val Arg Val Asp Leu His Leu Gly Tyr Phe Asp Glu Gln Asn Leu Pro 545 550 555 560 Glu His Leu His Ala Ile Asp Pro Thr Trp Asp Asn Ala Thr Tyr Phe                 565 570 575 Leu Ser Ala Leu Thr Leu Arg Ser Arg Leu Pro Gly Lys Ile Ala Gly             580 585 590 Trp Arg Asp Arg Leu Tyr Leu Ser Met Glu Arg Asn Gln Ala Ser Arg         595 600 605 Thr Glu Ser Phe Lys Leu Gln Pro Ser Lys Thr Ile Thr Val Gly Thr     610 615 620 Glu leu his leu 625 <210> 551 <211> 1035 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (101) .. (1012) <223> RXN00297 <400> 551 aacaaggcac cggaaaacaa gcaacgcacc ttgcagaggt ggtcttaagc atcttggagc 60 aaaacaacat ggcacaataa cgatcatgca acaggtgctc atg ggt ttc acg gtg 115                                             Met Gly Phe Thr Val                                               1 5 gtg ttc atc gtc atc gga ata ggt tgg att ctc ggt aga aga gac acc 163 Val Phe Ile Val Ile Gly Ile Gly Trp Ile Leu Gly Arg Arg Asp Thr                  10 15 20 ttg ggc aca cat gcc cag aaa cct ttg agc ctg ttt gtc tat tac gtg 211 Leu Gly Thr His Ala Gln Lys Pro Leu Ser Leu Phe Val Tyr Tyr Val              25 30 35 gcc acc cca gcg ttg ttg ttt gat cgg gtc acc aag tca gat acc tcg 259 Ala Thr Pro Ala Leu Leu Phe Asp Arg Val Thr Lys Ser Asp Thr Ser          40 45 50 acg att ttc tct ctg aac ttc gtg gtc att gca ctc tct gcg ttg atc 307 Thr Ile Phe Ser Leu Asn Phe Val Val Ile Ala Leu Ser Ala Leu Ile      55 60 65 gta ggt ttc ctg ttt ttc cta ctc atg cgg ttc gtg atc aaa aga act 355 Val Gly Phe Leu Phe Phe Leu Leu Met Arg Phe Val Ile Lys Arg Thr  70 75 80 85 gcc gca gta tcg gtg atc ggc atg cta gct gcg tcc tac gcc aac gcc 403 Ala Ala Val Ser Val Ile Gly Met Leu Ala Ala Ser Tyr Ala Asn Ala                  90 95 100 ggt aac ctg ggt atc cct ttg gca gcc tat att ttg gat gat ttc acc 451 Gly Asn Leu Gly Ile Pro Leu Ala Ala Tyr Ile Leu Asp Asp Phe Thr             105 110 115 gtg gtg att ccc gtg att ttg ttc cag gtg gcg ttc tac gca ccg atc 499 Val Val Ile Pro Val Ile Leu Phe Gln Val Ala Phe Tyr Ala Pro Ile         120 125 130 acc atg acc atc atg gag atg ctg acc aac aag aaa tcc acc aac ttg 547 Thr Met Thr Ile Met Glu Met Leu Thr Asn Lys Lys Ser Thr Asn Leu     135 140 145 gtg cgc aac ctc ctg gtc acg cca cta acc aac acc atg gtg ctc gca 595 Val Arg Asn Leu Leu Val Thr Pro Leu Thr Asn Thr Met Val Leu Ala 150 155 160 165 gcg att gcc ggt att gct gtg tct ttg act tcg atg agc gtg ccc gtg 643 Ala Ile Ala Gly Ile Ala Val Ser Leu Thr Ser Met Ser Val Pro Val                 170 175 180 gtg att gct cag cca gtg gaa atg ttg gcg aat gct tca gtg cca ctg 691 Val Ile Ala Gln Pro Val Glu Met Leu Ala Asn Ala Ser Val Pro Leu             185 190 195 gct ttg gtg gtg ttc gga ctg tcc ttg tcc aag agc aag atc ctg gaa 739 Ala Leu Val Val Phe Gly Leu Ser Leu Ser Lys Ser Lys Ile Leu Glu         200 205 210 aag ggg cag gta tcc agg cgc gat gtg ttt acg gcg gca ctg ttc aag 787 Lys Gly Gln Val Ser Arg Arg Asp Val Phe Thr Ala Ala Leu Phe Lys     215 220 225 aat gtt ctg cac cca att gtt gcg gga ctt tta gcc tta gcc ttt ggt 835 Asn Val Leu His Pro Ile Val Ala Gly Leu Leu Ala Leu Ala Phe Gly 230 235 240 245 atg gaa ggt act gcc ttg ttg tcg gcg gtg att ctc ggt gca ctg cca 883 Met Glu Gly Thr Ala Leu Leu Ser Ala Val Ile Leu Gly Ala Leu Pro                 250 255 260 aca gcg cag aat gtc tac acc tac gcg ttg cga ttt aga aca gct gaa 931 Thr Ala Gln Asn Val Tyr Thr Tyr Ala Leu Arg Phe Arg Thr Ala Glu             265 270 275 tcg atg gcg aga gac aca ggg gtg gtc acc aca ctc att tcc ttc ccc 979 Ser Met Ala Arg Asp Thr Gly Val Val Thr Thr Leu Ile Ser Phe Pro         280 285 290 gta ttg gtg gcg gtc tcc att atc ttt gga tct tagggttagc attagtggtc 1032 Val Leu Val Ala Val Ser Ile Ile Phe Gly Ser     295 300 atg 1035 <210> 552 <211> 304 <212> PRT <213> Corynebacterium glutamicum <400> 552 Met Gly Phe Thr Val Val Phe Ile Val Ile Gly Ile Gly Trp Ile Leu   1 5 10 15 Gly Arg Arg Asp Thr Leu Gly Thr His Ala Gln Lys Pro Leu Ser Leu              20 25 30 Phe Val Tyr Tyr Val Ala Thr Pro Ala Leu Leu Phe Asp Arg Val Thr          35 40 45 Lys Ser Asp Thr Ser Thr Ile Phe Ser Leu Asn Phe Val Val Ile Ala      50 55 60 Leu Ser Ala Leu Ile Val Gly Phe Leu Phe Phe Leu Leu Met Arg Phe  65 70 75 80 Val Ile Lys Arg Thr Ala Ala Val Ser Val Ile Gly Met Leu Ala Ala                  85 90 95 Ser Tyr Ala Asn Ala Gly Asn Leu Gly Ile Pro Leu Ala Ala Tyr Ile             100 105 110 Leu Asp Asp Phe Thr Val Val Ile Pro Val Ile Leu Phe Gln Val Ala         115 120 125 Phe Tyr Ala Pro Ile Thr Met Thr Ile Met Glu Met Leu Thr Asn Lys     130 135 140 Lys Ser Thr Asn Leu Val Arg Asn Leu Leu Val Thr Pro Leu Thr Asn 145 150 155 160 Thr Met Val Leu Ala Ala Ile Ala Gly Ile Ala Val Ser Leu Thr Ser                 165 170 175 Met Ser Val Pro Val Val Ile Ala Gln Pro Val Glu Met Leu Ala Asn             180 185 190 Ala Ser Val Pro Leu Ala Leu Val Val Phe Gly Leu Ser Leu Ser Lys         195 200 205 Ser Lys Ile Leu Glu Lys Gly Gln Val Ser Arg Arg Asp Val Phe Thr     210 215 220 Ala Ala Leu Phe Lys Asn Val Leu His Pro Ile Val Ala Gly Leu Leu 225 230 235 240 Ala Leu Ala Phe Gly Met Glu Gly Thr Ala Leu Leu Ser Ala Val Ile                 245 250 255 Leu Gly Ala Leu Pro Thr Ala Gln Asn Val Tyr Thr Tyr Ala Leu Arg             260 265 270 Phe Arg Thr Ala Glu Ser Met Ala Arg Asp Thr Gly Val Val Thr Thr         275 280 285 Leu Ile Ser Phe Pro Val Leu Val Ala Val Ser Ile Ile Phe Gly Ser     290 295 300 <210> 553 <211> 353 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (343) <223> RXN03103 <400> 553 atcttcagag tcacttcttt cagtgtcatt tttctcggcc ctaatccccc gctggagttc 60 aatcagcgat tgcaaccttt tagatatata aggagacaac atg tct gca aag cgt 115                                             Met Ser Ala Lys Arg                                               1 5 act ttt acc cgt atc ggt gcg att ctt gga gca act gca ctt gcc gga 163 Thr Phe Thr Arg Ile Gly Ala Ile Leu Gly Ala Thr Ala Leu Ala Gly                  10 15 20 gtt acc ctc acc gcc tgt ggt gat tca agc ggt ggc gac gga ttc ctc 211 Val Thr Leu Thr Ala Cys Gly Asp Ser Ser Gly Gly Asp Gly Phe Leu              25 30 35 gca gcc att gaa aat ggt tct gtc aat gtc ggc acc aaa tac gat cag 259 Ala Ala Ile Glu Asn Gly Ser Val Asn Val Gly Thr Lys Tyr Asp Gln          40 45 50 cct ggt ctt ggc ctc cgc aac cca gac aac tcc atg agc ggt ctc gac 307 Pro Gly Leu Gly Leu Arg Asn Pro Asp Asn Ser Met Ser Gly Leu Asp      55 60 65 gtg gat gtt gct gaa tac gta att caa ctc cat cgc tgatgacaag 353 Val Asp Val Ala Glu Tyr Val Ile Gln Leu His Arg  70 75 80 <210> 554 <211> 81 <212> PRT <213> Corynebacterium glutamicum <400> 554 Met Ser Ala Lys Arg Thr Phe Thr Arg Ile Gly Ala Ile Leu Gly Ala   1 5 10 15 Thr Ala Leu Ala Gly Val Thr Leu Thr Ala Cys Gly Asp Ser Ser Gly              20 25 30 Gly Asp Gly Phe Leu Ala Ala Ile Glu Asn Gly Ser Val Asn Val Gly          35 40 45 Thr Lys Tyr Asp Gln Pro Gly Leu Gly Leu Arg Asn Pro Asp Asn Ser      50 55 60 Met Ser Gly Leu Asp Val Asp Val Ala Glu Tyr Val Ile Gln Leu His  65 70 75 80 Arg <210> 555 <211> 695 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (672) <223> RXN02993 <400> 555 gtt gct gaa tac gta gtc aac tcc atc gct gat gac aag ggc tgg gat 48 Val Ala Glu Tyr Val Val Asn Ser Ile Ala Asp Asp Lys Gly Trp Asp   1 5 10 15 cac ccc acc atc gaa tgg cgt gaa tcc cct tct gcg cag cgt gaa acc 96 His Pro Thr Ile Glu Trp Arg Glu Ser Pro Ser Ala Gln Arg Glu Thr              20 25 30 ctc att caa aac ggt gag gta gac atg atc gca gca acc tac tcc atc 144 Leu Ile Gln Asn Gly Glu Val Asp Met Ile Ala Ala Thr Tyr Ser Ile          35 40 45 aac gct ggc cgt tca gag tcc gtc aac ttc ggt ggc cca tac ctg ctt 192 Asn Ala Gly Arg Ser Glu Ser Val Asn Phe Gly Gly Pro Tyr Leu Leu      50 55 60 acc cac cag gct ctg ctt gtt cgc caa gat gac gat cgc att gaa acc 240 Thr His Gln Ala Leu Leu Val Arg Gln Asp Asp Asp Arg Ile Glu Thr  65 70 75 80 ctc gag gac ttg gat aac ggt ttg atc ctg tgc tcc gtt tcc gga tcc 288 Leu Glu Asp Leu Asp Asn Gly Leu Ile Leu Cys Ser Val Ser Gly Ser                  85 90 95 act cca gct cag aag gtc aag gat gtc ctc cca ggc gtt cag ctc caa 336 Thr Pro Ala Gln Lys Val Lys Asp Val Leu Pro Gly Val Gln Leu Gln             100 105 110 gaa tac gac acc tac tct tcc tgt gtt gag gca ctg tcc cag ggc aac 384 Glu Tyr Asp Thr Tyr Ser Ser Cys Val Glu Ala Leu Ser Gln Gly Asn         115 120 125 gtt gac gcc ctg acc act gac gcc acc atc ctc ttc ggc tac tcc cag 432 Val Asp Ala Leu Thr Thr Asp Ala Thr Ile Leu Phe Gly Tyr Ser Gln     130 135 140 cag tac gaa ggc gac ttc cgc gtt gtg gaa atg gaa aag gac ggc gag 480 Gln Tyr Glu Gly Asp Phe Arg Val Val Glu Met Glu Lys Asp Gly Glu 145 150 155 160 cca ttc acc gac gag tac tac ggc att ggc ctg aag aag gat gac cag 528 Pro Phe Thr Asp Glu Tyr Tyr Gly Ile Gly Leu Lys Lys Asp Asp Gln                 165 170 175 gaa ggc acc gac gct atc aac gcc gca ctt gag cgc atg tac gct gac 576 Glu Gly Thr Asp Ala Ile Asn Ala Ala Leu Glu Arg Met Tyr Ala Asp             180 185 190 ggc acc ttc cag cga ctg ctc acc gag aac ctc ggt gaa gac tcc gtg 624 Gly Thr Phe Gln Arg Leu Leu Thr Glu Asn Leu Gly Glu Asp Ser Val         195 200 205 gtt gtt gaa gaa ggc acc cca ggt gac ctc tcc ttc ctc gac gca agc 672 Val Val Glu Glu Gly Thr Pro Gly Asp Leu Ser Phe Leu Asp Ala Ser     210 215 220 tagtgtgacg gcttttaaaa gcc 695 <210> 556 <211> 224 <212> PRT <213> Corynebacterium glutamicum <400> 556 Val Ala Glu Tyr Val Val Asn Ser Ile Ala Asp Asp Lys Gly Trp Asp   1 5 10 15 His Pro Thr Ile Glu Trp Arg Glu Ser Pro Ser Ala Gln Arg Glu Thr              20 25 30 Leu Ile Gln Asn Gly Glu Val Asp Met Ile Ala Ala Thr Tyr Ser Ile          35 40 45 Asn Ala Gly Arg Ser Glu Ser Val Asn Phe Gly Gly Pro Tyr Leu Leu      50 55 60 Thr His Gln Ala Leu Leu Val Arg Gln Asp Asp Asp Arg Ile Glu Thr  65 70 75 80 Leu Glu Asp Leu Asp Asn Gly Leu Ile Leu Cys Ser Val Ser Gly Ser                  85 90 95 Thr Pro Ala Gln Lys Val Lys Asp Val Leu Pro Gly Val Gln Leu Gln             100 105 110 Glu Tyr Asp Thr Tyr Ser Ser Cys Val Glu Ala Leu Ser Gln Gly Asn         115 120 125 Val Asp Ala Leu Thr Thr Asp Ala Thr Ile Leu Phe Gly Tyr Ser Gln     130 135 140 Gln Tyr Glu Gly Asp Phe Arg Val Val Glu Met Glu Lys Asp Gly Glu 145 150 155 160 Pro Phe Thr Asp Glu Tyr Tyr Gly Ile Gly Leu Lys Lys Asp Asp Gln                 165 170 175 Glu Gly Thr Asp Ala Ile Asn Ala Ala Leu Glu Arg Met Tyr Ala Asp             180 185 190 Gly Thr Phe Gln Arg Leu Leu Thr Glu Asn Leu Gly Glu Asp Ser Val         195 200 205 Val Val Glu Glu Gly Thr Pro Gly Asp Leu Ser Phe Leu Asp Ala Ser     210 215 220 <210> 557 <211> 1590 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1567) <223> RXN00349 <400> 557 tgtgtacatc acaatggaat tcggggctag agtatctggt gaaccgtgca taaacgacct 60 gtgattggac tctttttcct tgcaaaatgt tttccagcgg atg ttg agt ttt gcg 115                                             Met leu ser phe ala                                               1 5 acc ctt cgt ggc cgc att tca aca gtt gac gct gca aaa gcc gca cct 163 Thr Leu Arg Gly Arg Ile Ser Thr Val Asp Ala Ala Lys Ala Ala Pro                  10 15 20 ccg cca tcg cca cta gcc ccg att gat ctc act gac cat agt caa gtg 211 Pro Pro Ser Pro Leu Ala Pro Ile Asp Leu Thr Asp His Ser Gln Val              25 30 35 gcc ggt gtg atg aat ttg gct gcg aga att ggc gat att ttg ctt tct 259 Ala Gly Val Met Asn Leu Ala Ala Arg Ile Gly Asp Ile Leu Leu Ser          40 45 50 tca ggt acg tca aat agt gac acc aag gta caa gtt cga gca gtg acc 307 Ser Gly Thr Ser Asn Ser Asp Thr Lys Val Gln Val Arg Ala Val Thr      55 60 65 tct gcg tac ggt ttg tac tac acg cac gtg gat atc acg ttg aat acg 355 Ser Ala Tyr Gly Leu Tyr Tyr Thr His Val Asp Ile Thr Leu Asn Thr  70 75 80 85 atc acc atc ttc acc aac atc ggt gtg gag agg aag atg ccg gtc aac 403 Ile Thr Ile Phe Thr Asn Ile Gly Val Glu Arg Lys Met Pro Val Asn                  90 95 100 gtg ttt cat gtt gta ggc aag ttg gac acc aac ttc tcc aaa ctg tct 451 Val Phe His Val Val Gly Lys Leu Asp Thr Asn Phe Ser Lys Leu Ser             105 110 115 gag gtt gac cgt ttg atc cgt tcc att cag gct ggt gcg acc ccg cct 499 Glu Val Asp Arg Leu Ile Arg Ser Ile Gln Ala Gly Ala Thr Pro Pro         120 125 130 gag gtt gcc gag aaa atc ctg gac gag ttg gag caa tcc cct gcg tct 547 Glu Val Ala Glu Lys Ile Leu Asp Glu Leu Glu Gln Ser Pro Ala Ser     135 140 145 tat ggt ttc cct gtt gcg ttg ctt ggc tgg gca atg atg ggt ggt gct 595 Tyr Gly Phe Pro Val Ala Leu Leu Gly Trp Ala Met Met Gly Gly Ala 150 155 160 165 gtt gct gtg ctg ttg ggt ggt gga tgg cag gtt tcc cta att gct ttt 643 Val Ala Val Leu Leu Gly Gly Gly Trp Gln Val Ser Leu Ile Ala Phe                 170 175 180 att acc gcg ttc acg atc att gcc acg acg tca ttt ttg gga aag aag 691 Ile Thr Ala Phe Thr Ile Ile Ala Thr Thr Ser Phe Leu Gly Lys Lys             185 190 195 ggt ttg cct act ttc ttc caa aat gtt gtt ggt ggt ttt att gcc acg 739 Gly Leu Pro Thr Phe Phe Gln Asn Val Val Gly Gly Phe Ile Ala Thr         200 205 210 ctg cct gca tcg att gct tat tct ttg gcg ttg caa ttt ggt ctt gag 787 Leu Pro Ala Ser Ile Ala Tyr Ser Leu Ala Leu Gln Phe Gly Leu Glu     215 220 225 atc aaa ccg agc cag atc atc gca tct gga att gtt gtg ctg ttg gca 835 Ile Lys Pro Ser Gln Ile Ile Ala Ser Gly Ile Val Val Leu Leu Ala 230 235 240 245 ggt ttg aca ctc gtg caa tct ctg cag gac ggc atc acg ggc gct ccg 883 Gly Leu Thr Leu Val Gln Ser Leu Gln Asp Gly Ile Thr Gly Ala Pro                 250 255 260 gtg aca gca agt gca cga ttt ttc gaa aca ctc ctg ttt acc ggc ggc 931 Val Thr Ala Ser Ala Arg Phe Phe Glu Thr Leu Leu Phe Thr Gly Gly             265 270 275 att gtt gct ggc gtg ggt ttg ggc att cag ctt tct gaa atc ttg cat 979 Ile Val Ala Gly Val Gly Leu Gly Ile Gln Leu Ser Glu Ile Leu His         280 285 290 gtc atg ttg cct gcc atg gag tcc gct gca gca cct aat tat tcg tct 1027 Val Met Leu Pro Ala Met Glu Ser Ala Ala Ala Pro Asn Tyr Ser Ser     295 300 305 aca ttc gcc cgc att atc gct ggt ggc gtc acc gca gcg gcc ttc gca 1075 Thr Phe Ala Arg Ile Ile Ala Gly Gly Val Thr Ala Ala Ala Phe Ala 310 315 320 325 gtg ggt tgt tac gcg gag tgg tcc tcg gtg att att gcg ggg ctt act 1123 Val Gly Cys Tyr Ala Glu Trp Ser Ser Val Ile Ile Ala Gly Leu Thr                 330 335 340 gcg ctg atg ggt tct gcg ttt tat tac ctc ttc gtt gtt tat tta ggc 1171 Ala Leu Met Gly Ser Ala Phe Tyr Tyr Leu Phe Val Val Tyr Leu Gly             345 350 355 ccc gtc tct gcc gct gcg att gct gca aca gca gtt ggt ttc act ggt 1219 Pro Val Ser Ala Ala Ala Ile Ala Ala Thr Ala Val Gly Phe Thr Gly         360 365 370 ggt ttg ctt gcc cgt cga ttc ttg att cca ccg ttg att gtg gcg att 1267 Gly Leu Leu Ala Arg Arg Phe Leu Ile Pro Pro Leu Ile Val Ala Ile     375 380 385 gcc ggc atc aca cca atg ctt cca ggt cta gca att tac cgc gga atg 1315 Ala Gly Ile Thr Pro Met Leu Pro Gly Leu Ala Ile Tyr Arg Gly Met 390 395 400 405 tac gcc acc ctg aat gat caa aca ctc atg ggt ttc acc aac att gcg 1363 Tyr Ala Thr Leu Asn Asp Gln Thr Leu Met Gly Phe Thr Asn Ile Ala                 410 415 420 gtt gct tta gcc act gct tca tca ctt gcc gct ggc gtg gtt ttg ggt 1411 Val Ala Leu Ala Thr Ala Ser Ser Leu Ala Ala Gly Val Val Leu Gly             425 430 435 gag tgg att gcc cgc agg cta cgt cgt cca cca cgc ttc aac cca tac 1459 Glu Trp Ile Ala Arg Arg Leu Arg Arg Pro Pro Arg Phe Asn Pro Tyr         440 445 450 cgt gca ttt acc aag gcg aat gag ttc tcc ttc cag gag gaa gct gag 1507 Arg Ala Phe Thr Lys Ala Asn Glu Phe Ser Phe Gln Glu Glu Ala Glu     455 460 465 cag aat cag cgc cgg cag aga aaa cgt cca aag act aat cag aga ttc 1555 Gln Asn Gln Arg Arg Gln Arg Lys Arg Pro Lys Thr Asn Gln Arg Phe 470 475 480 485 ggt aat aaa agg taaaaatcaa cctgcttagg cgt 1590 Gly Asn Lys Arg <210> 558 <211> 489 <212> PRT <213> Corynebacterium glutamicum <400> 558 Met Leu Ser Phe Ala Thr Leu Arg Gly Arg Ile Ser Thr Val Asp Ala   1 5 10 15 Ala Lys Ala Ala Pro Pro Pro Ser Pro Leu Ala Pro Ile Asp Leu Thr              20 25 30 Asp His Ser Gln Val Ala Gly Val Met Asn Leu Ala Ala Arg Ile Gly          35 40 45 Asp Ile Leu Leu Ser Ser Gly Thr Ser Asn Ser Asp Thr Lys Val Gln      50 55 60 Val Arg Ala Val Thr Ser Ala Tyr Gly Leu Tyr Tyr Thr His Val Asp  65 70 75 80 Ile Thr Leu Asn Thr Ile Thr Ile Phe Thr Asn Ile Gly Val Glu Arg                  85 90 95 Lys Met Pro Val Asn Val Phe His Val Val Gly Lys Leu Asp Thr Asn             100 105 110 Phe Ser Lys Leu Ser Glu Val Asp Arg Leu Ile Arg Ser Ile Gln Ala         115 120 125 Gly Ala Thr Pro Pro Glu Val Ala Glu Lys Ile Leu Asp Glu Leu Glu     130 135 140 Gln Ser Pro Ala Ser Tyr Gly Phe Pro Val Ala Leu Leu Gly Trp Ala 145 150 155 160 Met Met Gly Gly Ala Val Ala Val Leu Leu Gly Gly Gly Trp Gln Val                 165 170 175 Ser Leu Ile Ala Phe Ile Thr Ala Phe Thr Ile Ile Ala Thr Thr Ser             180 185 190 Phe Leu Gly Lys Lys Gly Leu Pro Thr Phe Phe Gln Asn Val Val Gly         195 200 205 Gly Phe Ile Ala Thr Leu Pro Ala Ser Ile Ala Tyr Ser Leu Ala Leu     210 215 220 Gln Phe Gly Leu Glu Ile Lys Pro Ser Gln Ile Ile Ala Ser Gly Ile 225 230 235 240 Val Val Leu Leu Ala Gly Leu Thr Leu Val Gln Ser Leu Gln Asp Gly                 245 250 255 Ile Thr Gly Ala Pro Val Thr Ala Ser Ala Arg Phe Phe Glu Thr Leu             260 265 270 Leu Phe Thr Gly Gly Ile Val Ala Gly Val Gly Leu Gly Ile Gln Leu         275 280 285 Ser Glu Ile Leu His Val Met Leu Pro Ala Met Glu Ser Ala Ala Ala     290 295 300 Pro Asn Tyr Ser Ser Thr Phe Ala Arg Ile Ile Ala Gly Gly Val Thr 305 310 315 320 Ala Ala Ala Phe Ala Val Gly Cys Tyr Ala Glu Trp Ser Ser Val Ile                 325 330 335 Ile Ala Gly Leu Thr Ala Leu Met Gly Ser Ala Phe Tyr Tyr Leu Phe             340 345 350 Val Val Tyr Leu Gly Pro Val Ser Ala Ala Ala Ile Ala Ala Thr Ala         355 360 365 Val Gly Phe Thr Gly Gly Leu Leu Ala Arg Arg Phe Leu Ile Pro Pro     370 375 380 Leu Ile Val Ala Ile Ala Gly Ile Thr Pro Met Leu Pro Gly Leu Ala 385 390 395 400 Ile Tyr Arg Gly Met Tyr Ala Thr Leu Asn Asp Gln Thr Leu Met Gly                 405 410 415 Phe Thr Asn Ile Ala Val Ala Leu Ala Thr Ala Ser Ser Leu Ala Ala             420 425 430 Gly Val Val Leu Gly Glu Trp Ile Ala Arg Arg Leu Arg Arg Pro Pro         435 440 445 Arg Phe Asn Pro Tyr Arg Ala Phe Thr Lys Ala Asn Glu Phe Ser Phe     450 455 460 Gln Glu Glu Ala Glu Gln Asn Gln Arg Arg Gln Arg Lys Arg Pro Lys 465 470 475 480 Thr Asn Gln Arg Phe Gly Asn Lys Arg                 485 <210> 559 <211> 492 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (469) <223> RXN03095 <400> 559 aacgcctcaa ttagtgccag accttgccga ccgcagacca aacttcacca tttcaaacca 60 tccctagcca caacaacggc agttgtgcaa tgatctgcgt atg aat gca gat aag 115                                             Met Asn Ala Asp Lys                                               1 5 aaa atg tgc gga atg aac ccg gat agc caa tac gtc gaa ctt gcc gtc 163 Lys Met Cys Gly Met Asn Pro Asp Ser Gln Tyr Val Glu Leu Ala Val                  10 15 20 gaa gtt ttc gga ctc ctc gcg gac gcc act cga gtt cgc atc atc ttg 211 Glu Val Phe Gly Leu Leu Ala Asp Ala Thr Arg Val Arg Ile Ile Leu              25 30 35 gca ctt cga aac agt ggt gaa ctt tcc gta aac cac ctc gcg gac atc 259 Ala Leu Arg Asn Ser Gly Glu Leu Ser Val Asn His Leu Ala Asp Ile          40 45 50 gtc gat aaa tcc ccc gca gca gtt tcc caa cac ctc gcc cgg ctg cgc 307 Val Asp Lys Ser Pro Ala Ala Val Ser Gln His Leu Ala Arg Leu Arg      55 60 65 atg gcc cga atc gtg tcc acc cgt caa gaa ggt caa cga gtt ttc tac 355 Met Ala Arg Ile Val Ser Thr Arg Gln Glu Gly Gln Arg Val Phe Tyr  70 75 80 85 aaa ctc acc aat gaa cac gca tca cag cta gtc tcc gac gct att ttt 403 Lys Leu Thr Asn Glu His Ala Ser Gln Leu Val Ser Asp Ala Ile Phe                  90 95 100 cag gcg gaa cac acc att gcg gac ggc cag act ccc cca cac cac cac 451 Gln Ala Glu His Thr Ile Ala Asp Gly Gln Thr Pro Pro His His His             105 110 115 cga gaa cga gaa caa tca tgaccaccca cagtcaccaa gaa 492 Arg Glu Arg Glu Gln Ser         120 <210> 560 <211> 123 <212> PRT <213> Corynebacterium glutamicum <400> 560 Met Asn Ala Asp Lys Lys Met Cys Gly Met Asn Pro Asp Ser Gln Tyr   1 5 10 15 Val Glu Leu Ala Val Glu Val Phe Gly Leu Leu Ala Asp Ala Thr Arg              20 25 30 Val Arg Ile Ile Leu Ala Leu Arg Asn Ser Gly Glu Leu Ser Val Asn          35 40 45 His Leu Ala Asp Ile Val Asp Lys Ser Pro Ala Ala Val Ser Gln His      50 55 60 Leu Ala Arg Leu Arg Met Ala Arg Ile Val Ser Thr Arg Gln Glu Gly  65 70 75 80 Gln Arg Val Phe Tyr Lys Leu Thr Asn Glu His Ala Ser Gln Leu Val                  85 90 95 Ser Asp Ala Ile Phe Gln Ala Glu His Thr Ile Ala Asp Gly Gln Thr             100 105 110 Pro Pro His His His Arg Glu Arg Glu Gln Ser         115 120 <210> 561 <211> 591 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (568) <223> RXN03160 <400> 561 gagcatatgg tgcgcgcggc cgatatgctg atcaattcca accccgatcc gcacgcttaa 60 cttctgccaa aaagtcgttt tgaccataag ctaagcgatt gtg aat cga att gca 115                                             Val Asn Arg Ile Ala                                               1 5 gaa atc gca cgc agt ttc ggc gtg ctg ggc ttc agc gct ttc ggc ggc 163 Glu Ile Ala Arg Ser Phe Gly Val Leu Gly Phe Ser Ala Phe Gly Gly                  10 15 20 ccc acc gcg cac ctc gga tat ttc cgc acg gaa ttc gtg gag cgg cgg 211 Pro Thr Ala His Leu Gly Tyr Phe Arg Thr Glu Phe Val Glu Arg Arg              25 30 35 cgc tgg ctg gat gat cgc caa tat tcc gag atc gta gcg ctc agc caa 259 Arg Trp Leu Asp Asp Arg Gln Tyr Ser Glu Ile Val Ala Leu Ser Gln          40 45 50 cta ctt ccc gga cct gga tcg tcg cag gtc ggt atg atg ctg ggc tac 307 Leu Leu Pro Gly Pro Gly Ser Ser Gln Val Gly Met Met Leu Gly Tyr      55 60 65 cac cgc gcc ggt ttt tcc ggc atg gcg atc gcc tgg ctc atg ttt acc 355 His Arg Ala Gly Phe Ser Gly Met Ala Ile Ala Trp Leu Met Phe Thr  70 75 80 85 tgg ccc tca ttg gcg ctc atg gcg gcg ttc gcc ctg ctt ttt gat gcg 403 Trp Pro Ser Leu Ala Leu Met Ala Ala Phe Ala Leu Leu Phe Asp Ala                  90 95 100 acc tcc gcc agc tgg acg ctc ggc ctg ctc gcc gca gcg gtc gcc gtc 451 Thr Ser Ala Ser Trp Thr Leu Gly Leu Leu Ala Ala Ala Val Ala Val             105 110 115 gtt ttc aaa cgc agt cac cgg gca tgg cgc ggt tca atg gct tcc acg 499 Val Phe Lys Arg Ser His Arg Ala Trp Arg Gly Ser Met Ala Ser Thr         120 125 130 ccg ggg cgc cgg cca cca tcg ggg gtc ggc ctc ggg gca tcg cgg gtg 547 Pro Gly Arg Arg Pro Pro Ser Gly Val Gly Leu Gly Ala Ser Arg Val     135 140 145 ctc ggc cct ccc caa cgg ggt taacacacct tggggttcaa tca 591 Leu Gly Pro Pro Gln Arg Gly 150 155 <210> 562 <211> 156 <212> PRT <213> Corynebacterium glutamicum <400> 562 Val Asn Arg Ile Ala Glu Ile Ala Arg Ser Phe Gly Val Leu Gly Phe   1 5 10 15 Ser Ala Phe Gly Gly Pro Thr Ala His Leu Gly Tyr Phe Arg Thr Glu              20 25 30 Phe Val Glu Arg Arg Arg Trp Leu Asp Asp Arg Gln Tyr Ser Glu Ile          35 40 45 Val Ala Leu Ser Gln Leu Leu Pro Gly Pro Gly Ser Ser Gln Val Gly      50 55 60 Met Met Leu Gly Tyr His Arg Ala Gly Phe Ser Gly Met Ala Ile Ala  65 70 75 80 Trp Leu Met Phe Thr Trp Pro Ser Leu Ala Leu Met Ala Ala Phe Ala                  85 90 95 Leu Leu Phe Asp Ala Thr Ser Ala Ser Trp Thr Leu Gly Leu Leu Ala             100 105 110 Ala Ala Val Ala Val Val Phe Lys Arg Ser His Arg Ala Trp Arg Gly         115 120 125 Ser Met Ala Ser Thr Pro Gly Arg Arg Pro Pro Ser Gly Val Gly Leu     130 135 140 Gly Ala Ser Arg Val Leu Gly Pro Pro Gln Arg Gly 145 150 155 <210> 563 <211> 645 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (622) <223> RXN02955 <400> 563 atgcactggc tcccatcaaa gacgaattct tgacctcaga attccagcgt gaactctacg 60 aagcagtgcg cgccgctgat acttcaggag gtgcggcatc atg atg aat ttt aag 115                                             Met Met Asn Phe Lys                                               1 5 tcc atc gtg tgc gtc act gcc tgg cag gtg ttt agc cgc cag gtg ctg 163 Ser Ile Val Cys Val Thr Ala Trp Gln Val Phe Ser Arg Gln Val Leu                  10 15 20 cac agc cca tca acg tgg tct gaa gaa cta tcc aag ctg ttg ttc gtg 211 His Ser Pro Ser Thr Trp Ser Glu Glu Leu Ser Lys Leu Leu Phe Val              25 30 35 tgg cta tct ttc gca ggt agt gcg ttc ctc ttt gga gag cgt gga cat 259 Trp Leu Ser Phe Ala Gly Ser Ala Phe Leu Phe Gly Glu Arg Gly His          40 45 50 att gcg gtt gat ttc atc gcg cgc aaa ctg cct gtt tct gcg cag cgg 307 Ile Ala Val Asp Phe Ile Ala Arg Lys Leu Pro Val Ser Ala Gln Arg      55 60 65 gtc ctg cag gtc att gtt cag ttg ttg att gtt gtt ttt gcg atc ctc 355 Val Leu Gln Val Ile Val Gln Leu Leu Ile Val Val Phe Ala Ile Leu  70 75 80 85 ggc atg atc tgg ggt ggc tac ttg gct gca tca atc gcg tgg aat cag 403 Gly Met Ile Trp Gly Gly Tyr Leu Ala Ala Ser Ile Ala Trp Asn Gln                  90 95 100 cag ctc act gcg ctg cca ctt acc ttg gga tgg gtg tat gtt gtc atc 451 Gln Leu Thr Ala Leu Pro Leu Thr Leu Gly Trp Val Tyr Val Val Ile             105 110 115 ccg atc gcg ggt gtg ttc atc gcg ttg ttc gcg atc atc gat ctc atc 499 Pro Ile Ala Gly Val Phe Ile Ala Leu Phe Ala Ile Ile Asp Leu Ile         120 125 130 gaa gtg gcc aca ggc aag gaa gag cct tac ccc ctt gtt gat gaa tca 547 Glu Val Ala Thr Gly Lys Glu Glu Pro Tyr Pro Leu Val Asp Glu Ser     135 140 145 gaa gaa cct cga gat ttg gac gag cta gag gcc caa agc gct ata gat 595 Glu Glu Pro Arg Asp Leu Asp Glu Leu Glu Ala Gln Ser Ala Ile Asp 150 155 160 165 tct gca agt tca gcg gaa ggt agg aac taatatgttg tcgccagcag 642 Ser Ala Ser Ser Ala Glu Gly Arg Asn                 170 ctg 645 <210> 564 <211> 174 <212> PRT <213> Corynebacterium glutamicum <400> 564 Met Met Asn Phe Lys Ser Ile Val Cys Val Thr Ala Trp Gln Val Phe   1 5 10 15 Ser Arg Gln Val Leu His Ser Pro Ser Thr Trp Ser Glu Glu Leu Ser              20 25 30 Lys Leu Leu Phe Val Trp Leu Ser Phe Ala Gly Ser Ala Phe Leu Phe          35 40 45 Gly Glu Arg Gly His Ile Ala Val Asp Phe Ile Ala Arg Lys Leu Pro      50 55 60 Val Ser Ala Gln Arg Val Leu Gln Val Ile Val Gln Leu Leu Ile Val  65 70 75 80 Val Phe Ala Ile Leu Gly Met Ile Trp Gly Gly Tyr Leu Ala Ala Ser                  85 90 95 Ile Ala Trp Asn Gln Gln Leu Thr Ala Leu Pro Leu Thr Leu Gly Trp             100 105 110 Val Tyr Val Val Ile Pro Ile Ala Gly Val Phe Ile Ala Leu Phe Ala         115 120 125 Ile Ile Asp Leu Ile Glu Val Ala Thr Gly Lys Glu Glu Pro Tyr Pro     130 135 140 Leu Val Asp Glu Ser Glu Glu Pro Arg Asp Leu Asp Glu Leu Glu Ala 145 150 155 160 Gln Ser Ala Ile Asp Ser Ala Ser Ser Ala Glu Gly Arg Asn                 165 170 <210> 565 <211> 754 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (754) <223> RXN03109 <400> 565 actggcgctt cccgatggtc aatcattggc ctttggtgcc caaactggcg agttgttgct 60 ccgcgcatcc cgcgaactgt atgtgcaggg cggcgagtag atg gtt gtg aag gag 115                                             Met Val Val Lys Glu                                               1 5 gtt gac gtc gaa aag caa aaa gct ggc cgg gtg cct ggt gct ata gct 163 Val Asp Val Glu Lys Gln Lys Ala Gly Arg Val Pro Gly Ala Ile Ala                  10 15 20 aag cgt cgg acc gtg cgg att gtg ctg ttt gtc gcg ctg ggc gcg atc 211 Lys Arg Arg Thr Val Arg Ile Val Leu Phe Val Ala Leu Gly Ala Ile              25 30 35 gtg att gcg gcg tcg ctg tgg tcg att ctg gtc ggc caa tac acc atc 259 Val Ile Ala Ala Ser Leu Trp Ser Ile Leu Val Gly Gln Tyr Thr Ile          40 45 50 ccg att cgc gat cta cct gcg att tta gcc tcc ggt ccg acc ggt gcg 307 Pro Ile Arg Asp Leu Pro Ala Ile Leu Ala Ser Gly Pro Thr Gly Ala      55 60 65 cag acg atg gcg gaa caa gtc gtg tgg caa atc cgc atg ccg cgc atc 355 Gln Thr Met Ala Glu Gln Val Val Trp Gln Ile Arg Met Pro Arg Ile  70 75 80 85 gtg ctg gga ctg ctc gtg ggt gcc gct ttg ggc gtg gcc ggc gcg ctg 403 Val Leu Gly Leu Leu Val Gly Ala Ala Leu Gly Val Ala Gly Ala Leu                  90 95 100 ttg cag gcg gtg ttt tcc aac ccg ctg gcg gaa ccg tcg atc atc ggc 451 Leu Gln Ala Val Phe Ser Asn Pro Leu Ala Glu Pro Ser Ile Ile Gly             105 110 115 gtg acc tcc ggc gcg ggc gtg ggt gct gct gcg gtg atc gtg ttt aac 499 Val Thr Ser Gly Ala Gly Val Gly Ala Ala Ala Val Ile Val Phe Asn         120 125 130 ctg aca ttt ttg ggc aca tcc acc gtc gca gtc ggc gcg ttt att acc 547 Leu Thr Phe Leu Gly Thr Ser Thr Val Ala Val Gly Ala Phe Ile Thr     135 140 145 gcg gtg atc acc acg att ttg gta tat cag ctg gcc aga agc cgt gga 595 Ala Val Ile Thr Thr Ile Leu Val Tyr Gln Leu Ala Arg Ser Arg Gly 150 155 160 165 cgt gtg caa gtg atc aac ctg atc ctg aca ggc ata gcc att aat gca 643 Arg Val Gln Val Ile Asn Leu Ile Leu Thr Gly Ile Ala Ile Asn Ala                 170 175 180 gta tcc ggc gcg ctg acc tca gtt ctt gat cta cat cgc gcc gac gag 691 Val Ser Gly Ala Leu Thr Ser Val Leu Asp Leu His Arg Ala Asp Glu             185 190 195 ctc ccg cga aga aat att ttc tgc aga tgg gtt cct cac ggc tcg cat 739 Leu Pro Arg Arg Asn Ile Phe Cys Arg Trp Val Pro His Gly Ser His         200 205 210 ggc gca cgt caa cgt 754 Gly Ala Arg Gln Arg     215 <210> 566 <211> 218 <212> PRT <213> Corynebacterium glutamicum <400> 566 Met Val Val Lys Glu Val Asp Val Glu Lys Gln Lys Ala Gly Arg Val   1 5 10 15 Pro Gly Ala Ile Ala Lys Arg Arg Thr Val Arg Ile Val Leu Phe Val              20 25 30 Ala Leu Gly Ala Ile Val Ile Ala Ala Ser Leu Trp Ser Ile Leu Val          35 40 45 Gly Gln Tyr Thr Ile Pro Ile Arg Asp Leu Pro Ala Ile Leu Ala Ser      50 55 60 Gly Pro Thr Gly Ala Gln Thr Met Ala Glu Gln Val Val Trp Gln Ile  65 70 75 80 Arg Met Pro Arg Ile Val Leu Gly Leu Leu Val Gly Ala Ala Leu Gly                  85 90 95 Val Ala Gly Ala Leu Leu Gln Ala Val Phe Ser Asn Pro Leu Ala Glu             100 105 110 Pro Ser Ile Ile Gly Val Thr Ser Gly Ala Gly Val Gly Ala Ala Ala         115 120 125 Val Ile Val Phe Asn Leu Thr Phe Leu Gly Thr Ser Thr Val Ala Val     130 135 140 Gly Ala Phe Ile Thr Ala Val Ile Thr Thr Ile Leu Val Tyr Gln Leu 145 150 155 160 Ala Arg Ser Arg Gly Arg Val Gln Val Ile Asn Leu Ile Leu Thr Gly                 165 170 175 Ile Ala Ile Asn Ala Val Ser Gly Ala Leu Thr Ser Val Leu Asp Leu             180 185 190 His Arg Ala Asp Glu Leu Pro Arg Arg Asn Ile Phe Cys Arg Trp Val         195 200 205 Pro His Gly Ser His Gly Ala Arg Gln Arg     210 215 <210> 567 <211> 357 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (334) <223> RXN02979 <400> 567 ctaggtcaag gaacttcact cggctagtcc ttagactcaa atgtgttcag acaaacactg 60 gcaccgtaag gcacgaaagt taccgaaagg actggttccc atg acc gcc cca aac 115                                             Met thr ala pro asn                                               1 5 act ctc aag caa aca act ctt cgc tct gat gag ttc tct tgc cca tcc 163 Thr Leu Lys Gln Thr Thr Leu Arg Ser Asp Glu Phe Ser Cys Pro Ser                  10 15 20 tgt gtc tcc aag att gaa aac aaa ttg aat gga ttg gat ggc gtc gac 211 Cys Val Ser Lys Ile Glu Asn Lys Leu Asn Gly Leu Asp Gly Val Asp              25 30 35 aat gca gag gtg aag ttc tcc tcc gga aga atc ctt gtt gat cac gac 259 Asn Ala Glu Val Lys Phe Ser Ser Gly Arg Ile Leu Val Asp His Asp          40 45 50 ccc agc aag gtc tct atc aag gat cta gtc gct gca gtc gca gag gtt 307 Pro Ser Lys Val Ser Ile Lys Asp Leu Val Ala Ala Val Ala Glu Val      55 60 65 ggc tac acc gca aag cca tca gca atc taaaactctc agttagacca 354 Gly Tyr Thr Ala Lys Pro Ser Ala Ile  70 75 tta 357 <210> 568 <211> 78 <212> PRT <213> Corynebacterium glutamicum <400> 568 Met Thr Ala Pro Asn Thr Leu Lys Gln Thr Thr Leu Arg Ser Asp Glu   1 5 10 15 Phe Ser Cys Pro Ser Cys Val Ser Lys Ile Glu Asn Lys Leu Asn Gly              20 25 30 Leu Asp Gly Val Asp Asn Ala Glu Val Lys Phe Ser Ser Gly Arg Ile          35 40 45 Leu Val Asp His Asp Pro Ser Lys Val Ser Ile Lys Asp Leu Val Ala      50 55 60 Ala Val Ala Glu Val Gly Tyr Thr Ala Lys Pro Ser Ala Ile  65 70 75 <210> 569 <211> 357 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (334) <223> RXN02987 <400> 569 gttgtttgat ccaggtcaag gaattaaccc ggaaaggacc gtatctttaa aggtgcaagc 60 acaggaacat gacgataaaa gatgaaagga cctggttacg atg acc gcc ccc gcc 115                                             Met thr ala pro ala                                               1 5 acg ctg aag aac acc acc ttg cgc tct gat gag ttc acc tgt ccg agc 163 Thr Leu Lys Asn Thr Thr Leu Arg Ser Asp Glu Phe Thr Cys Pro Ser                  10 15 20 tgt gtc gcc aag atc gaa aac aag ctg aat ggt ttg gac ggc gtg gag 211 Cys Val Ala Lys Ile Glu Asn Lys Leu Asn Gly Leu Asp Gly Val Glu              25 30 35 aat gcg gag gtg aag ttc tcc tcc gga cgc atc ctg atc acc cac gac 259 Asn Ala Glu Val Lys Phe Ser Ser Gly Arg Ile Leu Ile Thr His Asp          40 45 50 cca cag aag gtc tcc gta cgt gac ctg gtc acc gcg gta gcc gag gtc 307 Pro Gln Lys Val Ser Val Arg Asp Leu Val Thr Ala Val Ala Glu Val      55 60 65 ggt tac acc gcc aag ccg tcg gcg atc tgacgcactc ccgaccccac 354 Gly Tyr Thr Ala Lys Pro Ser Ala Ile  70 75 aag 357 <210> 570 <211> 78 <212> PRT <213> Corynebacterium glutamicum <400> 570 Met Thr Ala Pro Ala Thr Leu Lys Asn Thr Thr Leu Arg Ser Asp Glu   1 5 10 15 Phe Thr Cys Pro Ser Cys Val Ala Lys Ile Glu Asn Lys Leu Asn Gly              20 25 30 Leu Asp Gly Val Glu Asn Ala Glu Val Lys Phe Ser Ser Gly Arg Ile          35 40 45 Leu Ile Thr His Asp Pro Gln Lys Val Ser Val Arg Asp Leu Val Thr      50 55 60 Ala Val Ala Glu Val Gly Tyr Thr Ala Lys Pro Ser Ala Ile  65 70 75 <210> 571 <211> 1041 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (1018) <223> RXN03084 <400> 571 ccacccccac gtctaagttt tcccctattt acacacacct gaccgaagct gtaaggtttg 60 cctaatcttt ttcaatctaa agtcaggata ttcacagccc atg tca tct cgc aga 115                                             Met Ser Ser Arg Arg                                               1 5 aaa ctc tcc tcc gca ctg atc gtg ctt ctc gca gca gca cta cct ctt 163 Lys Leu Ser Ser Ala Leu Ile Val Leu Leu Ala Ala Ala Leu Pro Leu                  10 15 20 act gct tgt tcc tcc agc tca gaa gag gaa gca tcc acc agc tct gcg 211 Thr Ala Cys Ser Ser Ser Ser Glu Glu Glu Ala Ser Thr Ser Ser Ala              25 30 35 act cgc gaa ttc aca gac gct cac gga aca acc gaa gtt ccc gaa aat 259 Thr Arg Glu Phe Thr Asp Ala His Gly Thr Thr Glu Val Pro Glu Asn          40 45 50 cct cag cgc gtc gtt gtc ctc gag cca ctt gag cta gac acc gca atc 307 Pro Gln Arg Val Val Val Leu Glu Pro Leu Glu Leu Asp Thr Ala Ile      55 60 65 gcc ctc gga atc acc cca gtg ggt gca gct gtc gcc aac aac gtc act 355 Ala Leu Gly Ile Thr Pro Val Gly Ala Ala Val Ala Asn Asn Val Thr  70 75 80 85 ggt att cct gca tat ctc ggc gtc gat gga atc gag cct gtc ggc acc 403 Gly Ile Pro Ala Tyr Leu Gly Val Asp Gly Ile Glu Pro Val Gly Thr                  90 95 100 gtt tct gag cca aat atc gaa gcg atc gct gct ctc gag ccc gac ctg 451 Val Ser Glu Pro Asn Ile Glu Ala Ile Ala Ala Leu Glu Pro Asp Leu             105 110 115 atc ctg ggc acc gat tcc cgc cac gcc gaa atc tac gac cgc ctc gaa 499 Ile Leu Gly Thr Asp Ser Arg His Ala Glu Ile Tyr Asp Arg Leu Glu         120 125 130 tcc atc gcc cca acc gtg ttc atg aca acc cat gtt gat ccg tgg aaa 547 Ser Ile Ala Pro Thr Val Phe Met Thr Thr His Val Asp Pro Trp Lys     135 140 145 gac aat gtc gtc ttc atc ggc gat gca ttg ggc aag aag cag gaa tcc 595 Asp Asn Val Val Phe Ile Gly Asp Ala Leu Gly Lys Lys Gln Glu Ser 150 155 160 165 gag gat ctc atc caa ggc ttt aat gac aag tgc gaa gag atc aag tcc 643 Glu Asp Leu Ile Gln Gly Phe Asn Asp Lys Cys Glu Glu Ile Lys Ser                 170 175 180 gag cat gat gtc gaa ggt aag acc gtc aac atg att cgt ccc cgc gac 691 Glu His Asp Val Glu Gly Lys Thr Val Asn Met Ile Arg Pro Arg Asp             185 190 195 gag caa acc atg agc cta tac ggc ccg acc tca ttt gcc ggc agc tct 739 Glu Gln Thr Met Ser Leu Tyr Gly Pro Thr Ser Phe Ala Gly Ser Ser         200 205 210 ttg gag tgc gca gga ctc acc att cct gat cag gaa tgg aag gat gac 787 Leu Glu Cys Ala Gly Leu Thr Ile Pro Asp Gln Glu Trp Lys Asp Asp     215 220 225 ctc cag gcc gac atc gct cct gag aac ttc atg ctc gcc acc gcc gac 835 Leu Gln Ala Asp Ile Ala Pro Glu Asn Phe Met Leu Ala Thr Ala Asp 230 235 240 245 tac gtc ttt gtc acc gca act gat gtc acc gat gaa aat gag ctc ccc 883 Tyr Val Phe Val Thr Ala Thr Asp Val Thr Asp Glu Asn Glu Leu Pro                 250 255 260 gaa gta atc cga gaa aac cgc gaa cag ttc cca tca ctc acc ctt gtc 931 Glu Val Ile Arg Glu Asn Arg Glu Gln Phe Pro Ser Leu Thr Leu Val             265 270 275 gat acc agc tac tgg gta tct ggc gtc ggt cca ctt ggc ggc agc aaa 979 Asp Thr Ser Tyr Trp Val Ser Gly Val Gly Pro Leu Gly Gly Ser Lys         280 285 290 gtc ttg gaa gac atc gat gcc ttc ctc gac gca cag caa taatgtccac 1028 Val Leu Glu Asp Ile Asp Ala Phe Leu Asp Ala Gln Gln     295 300 305 agctctcccc gat 1041 <210> 572 <211> 306 <212> PRT <213> Corynebacterium glutamicum <400> 572 Met Ser Ser Arg Arg Lys Leu Ser Ser Ala Leu Ile Val Leu Leu Ala   1 5 10 15 Ala Ala Leu Pro Leu Thr Ala Cys Ser Ser Ser Ser Glu Glu Glu Ala              20 25 30 Ser Thr Ser Ser Ala Thr Arg Glu Phe Thr Asp Ala His Gly Thr Thr          35 40 45 Glu Val Pro Glu Asn Pro Gln Arg Val Val Val Leu Glu Pro Leu Glu      50 55 60 Leu Asp Thr Ala Ile Ala Leu Gly Ile Thr Pro Val Gly Ala Ala Val  65 70 75 80 Ala Asn Asn Val Thr Gly Ile Pro Ala Tyr Leu Gly Val Asp Gly Ile                  85 90 95 Glu Pro Val Gly Thr Val Ser Glu Pro Asn Ile Glu Ala Ile Ala Ala             100 105 110 Leu Glu Pro Asp Leu Ile Leu Gly Thr Asp Ser Arg His Ala Glu Ile         115 120 125 Tyr Asp Arg Leu Glu Ser Ile Ala Pro Thr Val Phe Met Thr Thr His     130 135 140 Val Asp Pro Trp Lys Asp Asn Val Val Phe Ile Gly Asp Ala Leu Gly 145 150 155 160 Lys Lys Gln Glu Ser Glu Asp Leu Ile Gln Gly Phe Asn Asp Lys Cys                 165 170 175 Glu Glu Ile Lys Ser Glu His Asp Val Glu Gly Lys Thr Val Asn Met             180 185 190 Ile Arg Pro Arg Asp Glu Gln Thr Met Ser Leu Tyr Gly Pro Thr Ser         195 200 205 Phe Ala Gly Ser Ser Leu Glu Cys Ala Gly Leu Thr Ile Pro Asp Gln     210 215 220 Glu Trp Lys Asp Asp Leu Gln Ala Asp Ile Ala Pro Glu Asn Phe Met 225 230 235 240 Leu Ala Thr Ala Asp Tyr Val Phe Val Thr Ala Thr Asp Val Thr Asp                 245 250 255 Glu Asn Glu Leu Pro Glu Val Ile Arg Glu Asn Arg Glu Gln Phe Pro             260 265 270 Ser Leu Thr Leu Val Asp Thr Ser Tyr Trp Val Ser Gly Val Gly Pro         275 280 285 Leu Gly Gly Ser Lys Val Leu Glu Asp Ile Asp Ala Phe Leu Asp Ala     290 295 300 Gln Gln 305 <210> 573 <211> 440 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (417) <223> RXN03183 <400> 573 gaa gcc gaa gca acc gca ggc aaa ttc gaa gta cag ccc ctc gta ggt 48 Glu Ala Glu Ala Thr Ala Gly Lys Phe Glu Val Gln Pro Leu Val Gly   1 5 10 15 aaa gac ggc gtc ggc gta tcc acc ctt ggt ggc tac aac aac ggc atc 96 Lys Asp Gly Val Gly Val Ser Thr Leu Gly Gly Tyr Asn Asn Gly Ile              20 25 30 aac gtc aac tcc gaa aac aag gca acc gcc cgc gac ttc atc gaa ttc 144 Asn Val Asn Ser Glu Asn Lys Ala Thr Ala Arg Asp Phe Ile Glu Phe          35 40 45 atc atc aac gaa gag aac caa acc tgg ttc gcg gac aac tcc ttc cca 192 Ile Ile Asn Glu Glu Asn Gln Thr Trp Phe Ala Asp Asn Ser Phe Pro      50 55 60 cca gtt ctg gca tcc atc tac gat gat gag tcc ctt gtt gag cag tac 240 Pro Val Leu Ala Ser Ile Tyr Asp Asp Glu Ser Leu Val Glu Gln Tyr  65 70 75 80 cca tac ctg cca gca ctg aag gaa tcc ctg gaa aac gca gca cca cgc 288 Pro Tyr Leu Pro Ala Leu Lys Glu Ser Leu Glu Asn Ala Ala Pro Arg                  85 90 95 cca gtg tct cct ttc tac cca gcc atc tcc aag gca atc cag gac aac 336 Pro Val Ser Pro Phe Tyr Pro Ala Ile Ser Lys Ala Ile Gln Asp Asn             100 105 110 gcc tac gca gcg ctt aac ggc aac gtc gac gtt gac cag gca acc acc 384 Ala Tyr Ala Ala Leu Asn Gly Asn Val Asp Val Asp Gln Ala Thr Thr         115 120 125 gat atg aag gca gcg atc gaa aac gct tcc agc tagttcggta atttagttca 437 Asp Met Lys Ala Ala Ile Glu Asn Ala Ser Ser     130 135 ttc 440 <210> 574 <211> 139 <212> PRT <213> Corynebacterium glutamicum <400> 574 Glu Ala Glu Ala Thr Ala Gly Lys Phe Glu Val Gln Pro Leu Val Gly   1 5 10 15 Lys Asp Gly Val Gly Val Ser Thr Leu Gly Gly Tyr Asn Asn Gly Ile              20 25 30 Asn Val Asn Ser Glu Asn Lys Ala Thr Ala Arg Asp Phe Ile Glu Phe          35 40 45 Ile Ile Asn Glu Glu Asn Gln Thr Trp Phe Ala Asp Asn Ser Phe Pro      50 55 60 Pro Val Leu Ala Ser Ile Tyr Asp Asp Glu Ser Leu Val Glu Gln Tyr  65 70 75 80 Pro Tyr Leu Pro Ala Leu Lys Glu Ser Leu Glu Asn Ala Ala Pro Arg                  85 90 95 Pro Val Ser Pro Phe Tyr Pro Ala Ile Ser Lys Ala Ile Gln Asp Asn             100 105 110 Ala Tyr Ala Ala Leu Asn Gly Asn Val Asp Val Asp Gln Ala Thr Thr         115 120 125 Asp Met Lys Ala Ala Ile Glu Asn Ala Ser Ser     130 135 <210> 575 <211> 1077 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (1054) <223> RXN01139 <400> 575 accaccgtgg caggcttttt cagtggcaag aagattaatt ctccacccct tcattttcaa 60 taagctttca ataaggggag aagtgtgctt agctggggtc atg gaa agc cac gat 115                                             Met Glu Ser His Asp                                               1 5 ctt cag cag cgc agt tat gcg cac aat ccc gat ggc cac gac cac agc 163 Leu Gln Gln Arg Ser Tyr Ala His Asn Pro Asp Gly His Asp His Ser                  10 15 20 cat gac gga ctc gga cac tca cat gct ccc agc tcc ctc aag gct ctt 211 His Asp Gly Leu Gly His Ser His Ala Pro Ser Ser Leu Lys Ala Leu              25 30 35 ttt gcg gtc atc att ttc acc tcg atc atc ttc cta gcg gaa cta atc 259 Phe Ala Val Ile Ile Phe Thr Ser Ile Phe Leu Ala Glu Leu Ile          40 45 50 gcc ggc ctt att tcc gga tct ttg gca ctg ctg gct gac gcc atg cac 307 Ala Gly Leu Ile Ser Gly Ser Leu Ala Leu Leu Ala Asp Ala Met His      55 60 65 atg ctg tcc gac tcc act ggc ttg atc att gcg gct gtc gcc atg ctc 355 Met Leu Ser Asp Ser Thr Gly Leu Ile Ile Ala Ala Val Ala Met Leu  70 75 80 85 att ggc cgt cgg gca cgc act tct cgt gcg acc tac gga tac aag cgt 403 Ile Gly Arg Arg Ala Arg Thr Ser Arg Ala Thr Tyr Gly Tyr Lys Arg                  90 95 100 gcg gaa gtc ttg gca gcg atg gtt aac gcc acc gtt gtt aca gca ctg 451 Ala Glu Val Leu Ala Ala Met Val Asn Ala Thr Val Val Thr Ala Leu             105 110 115 tct gtg tgg atc gtc gtt gag gcc atc atg cgt ctg ggc aag gac ctg 499 Ser Val Trp Ile Val Val Glu Ala Ile Met Arg Leu Gly Lys Asp Leu         120 125 130 gaa atc cag acc aac ctg atg ctc atc gtc gcg gtc att ggt ttt gtc 547 Glu Ile Gln Thr Asn Leu Met Leu Ile Val Ala Val Ile Gly Phe Val     135 140 145 acc aac gga att tcc gcc ctg gtg ttg atg cgc cac caa gat ggc aat 595 Thr Asn Gly Ile Ser Ala Leu Val Leu Met Arg His Gln Asp Gly Asn 150 155 160 165 atc aat atg cgt gga gca ttc ctt cac gtt ctc agt gac atg ctg ggt 643 Ile Asn Met Arg Gly Ala Phe Leu His Val Leu Ser Asp Met Leu Gly                 170 175 180 tcc gtt gcc gtc att att gcg ggc ctg gtg att cgc tac acg gga tgg 691 Ser Val Ala Val Ile Ile Ala Gly Leu Val Ile Arg Tyr Thr Gly Trp             185 190 195 atg ccg gcc gat acc att gct tcg att gcg att gct gcg att att att 739 Met Pro Ala Asp Thr Ile Ala Ser Ile Ala Ile Ala Ala Ile Ile Ile         200 205 210 cct cgc gca ttc agc ctc ctg aag gaa gct ctc aat atc ttg ttg gag 787 Pro Arg Ala Phe Ser Leu Leu Lys Glu Ala Leu Asn Ile Leu Leu Glu     215 220 225 cgt gtt cct aca ggt gcg gag cct gca gag gtc gac gca gcc ctt cgt 835 Arg Val Pro Thr Gly Ala Glu Pro Ala Glu Val Asp Ala Ala Leu Arg 230 235 240 245 aaa gtc cca ggt gtc agc gat gtg cat gat ctt cac att tgg agc att 883 Lys Val Pro Gly Val Ser Asp Val His Asp Leu His Ile Trp Ser Ile                 250 255 260 gac ggc aag gaa atc ctg gcc acg gtg cat ttg gtg gtg gat tcg tct 931 Asp Gly Lys Glu Ile Leu Ala Thr Val His Leu Val Val Asp Ser Ser             265 270 275 aca aat cag ctg cat agt tgt ggc gtg ttg gat cgg gca gaa gcg gaa 979 Thr Asn Gln Leu His Ser Cys Gly Val Leu Asp Arg Ala Glu Ala Glu         280 285 290 cta tcc aaa ctt ggg atc ttg cac tca aca att cag ctg gaa agc gca 1027 Leu Ser Lys Leu Gly Ile Leu His Ser Thr Ile Gln Leu Glu Ser Ala     295 300 305 gat cac agt gat cat gaa agt gtg tgc tgatatagag tatgtcccat 1074 Asp His Ser Asp His Glu Ser Val Cys 310 315 ggg 1077 <210> 576 <211> 318 <212> PRT <213> Corynebacterium glutamicum <400> 576 Met Glu Ser His Asp Leu Gln Gln Arg Ser Tyr Ala His Asn Pro Asp   1 5 10 15 Gly His Asp His Ser His Asp Gly Leu Gly His Ser His Ala Pro Ser              20 25 30 Ser Leu Lys Ala Leu Phe Ala Val Ile Ile Phe Thr Ser Ile Ile Phe          35 40 45 Leu Ala Glu Leu Ile Ala Gly Leu Ile Ser Gly Ser Leu Ala Leu Leu      50 55 60 Ala Asp Ala Met His Met Leu Ser Asp Ser Thr Gly Leu Ile Ila Ala  65 70 75 80 Ala Val Ala Met Leu Ile Gly Arg Arg Ala Arg Thr Ser Arg Ala Thr                  85 90 95 Tyr Gly Tyr Lys Arg Ala Glu Val Leu Ala Ala Met Val Asn Ala Thr             100 105 110 Val Val Thr Ala Leu Ser Val Trp Ile Val Val Glu Ala Ile Met Arg         115 120 125 Leu Gly Lys Asp Leu Glu Ile Gln Thr Asn Leu Met Leu Ile Val Ala     130 135 140 Val Ile Gly Phe Val Thr Asn Gly Ile Ser Ala Leu Val Leu Met Arg 145 150 155 160 His Gln Asp Gly Asn Ile Asn Met Arg Gly Ala Phe Leu His Val Leu                 165 170 175 Ser Asp Met Leu Gly Ser Val Ala Val Ile Ala Gly Leu Val Ile             180 185 190 Arg Tyr Thr Gly Trp Met Pro Ala Asp Thr Ile Ala Ser Ile Ala Ile         195 200 205 Ala Ala Ile Ile Ile Pro Arg Ala Phe Ser Leu Leu Lys Glu Ala Leu     210 215 220 Asn Ile Leu Leu Glu Arg Val Pro Thr Gly Ala Glu Pro Ala Glu Val 225 230 235 240 Asp Ala Ala Leu Arg Lys Val Pro Gly Val Ser Asp Val His Asp Leu                 245 250 255 His Ile Trp Ser Ile Asp Gly Lys Glu Ile Leu Ala Thr Val His Leu             260 265 270 Val Val Asp Ser Ser Thr Asn Gln Leu His Ser Cys Gly Val Leu Asp         275 280 285 Arg Ala Glu Ala Glu Leu Ser Lys Leu Gly Ile Leu His Ser Thr Ile     290 295 300 Gln Leu Glu Ser Ala Asp His Ser Asp His Glu Ser Val Cys 305 310 315 <210> 577 <211> 2733 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (2710) <223> RXN00378 <400> 577 accgtgagcc ttatactgtg aggacattaa aagtgacacc tctttttcta tcttttacaa 60 cccaagaagg tttatcgtga gcacaccgga ttcttcctcg gtg gac aag gcc gta 115                                             Val Asp Lys Ala Val                                               1 5 aac act gct atc tct gac gcc aaa aca gcg gcg ctc aag gca ggt gtt 163 Asn Thr Ala Ile Ser Asp Ala Lys Thr Ala Ala Leu Lys Ala Gly Val                  10 15 20 gga ttg aac cga gcc acc gcc tca gaa gaa gag gaa gat tta agc tca 211 Gly Leu Asn Arg Ala Thr Ala Ser Glu Glu Glu Glu Asp Leu Ser Ser              25 30 35 agc att aag gtt tct ttg gcc ttt gag ctc gag ggg tta agc aat gca 259 Ser Ile Lys Val Ser Leu Ala Phe Glu Leu Glu Gly Leu Ser Asn Ala          40 45 50 cca tcg ttg atg gtg gtg gaa aaa gcc cta gag aag atc ccc ggt gta 307 Pro Ser Leu Met Val Val Glu Lys Ala Leu Glu Lys Ile Pro Gly Val      55 60 65 tcc gcg gat ctg att tac cct tca caa act gca tgg att aca gca act 355 Ser Ala Asp Leu Ile Tyr Pro Ser Gln Thr Ala Trp Ile Thr Ala Thr  70 75 80 85 gat cgg gta cat ccc gaa acc ctc att gag gtg ttt gag cag ttc ggc 403 Asp Arg Val His Pro Glu Thr Leu Ile Glu Val Phe Glu Gln Phe Gly                  90 95 100 atc aaa gca cac ctt tct aat tca tcg ctg ctg cgc agg cat caa cag 451 Ile Lys Ala His Leu Ser Asn Ser Ser Leu Leu Arg Arg His Gln Gln             105 110 115 ctc agc gcg gaa gta aat agg gaa gca cgc ctt gat cgt tac cgc tcc 499 Leu Ser Ala Glu Val Asn Arg Glu Ala Arg Leu Asp Arg Tyr Arg Ser         120 125 130 cga atg gat gcc aag cga atc tcg cct cgt gtg cga agg cat aac cga 547 Arg Met Asp Ala Lys Arg Ile Ser Pro Arg Val Arg Arg His Asn Arg     135 140 145 caa gaa atg gta cat gcg gta cgc gct cgt gaa agt ggt tgg att aaa 595 Gln Glu Met Val His Ala Val Arg Ala Arg Glu Ser Gly Trp Ile Lys 150 155 160 165 cgc agg aat cac acc acc tcg cag cat gaa gac cca atg tcg ggc gat 643 Arg Arg Asn His Thr Thr Ser Gln His Glu Asp Pro Met Ser Gly Asp                 170 175 180 gtg ctg ttc acc gcc cgc gca ctg att aca cct aag cgt ttg tgg gtg 691 Val Leu Phe Thr Ala Arg Ala Leu Ile Thr Pro Lys Arg Leu Trp Val             185 190 195 tcg ttg ccg ttt gcg ctc atc gta ttg gcg tta tcg ttg aat cct tcg 739 Ser Leu Pro Phe Ala Leu Ile Val Leu Ala Leu Ser Leu Asn Pro Ser         200 205 210 tgg cag ttt gat tat tgg cag tgg ttg tcc gct gtg ttg gct att cct 787 Trp Gln Phe Asp Tyr Trp Gln Trp Leu Ser Ala Val Leu Ala Ile Pro     215 220 225 gtg gtg gtg tgg ggt gcc tgg ccg ttt cac cgc gct gca gca ggc ggt 835 Val Val Val Trp Gly Ala Trp Pro Phe His Arg Ala Ala Ala Gly Gly 230 235 240 245 att cgt cga gga att tcc gct ctt gat gcg acc agc tca atc gct att 883 Ile Arg Arg Gly Ile Ser Ala Leu Asp Ala Thr Ser Ser Ile Ala Ile                 250 255 260 gct gct gca tac gcg tgg tct atc gcc atg ctg ttg ttt gaa acc cca 931 Ala Ala Ala Tyr Ala Trp Ser Ile Ala Met Leu Leu Phe Glu Thr Pro             265 270 275 gga ggt aaa tcc tgg cgg tca tat ccg tcc tgg ttc gct ttt gac cac 979 Gly Gly Lys Ser Trp Arg Ser Tyr Pro Ser Trp Phe Ala Phe Asp His         280 285 290 ggc acg ttg acc caa aac gag att tat ttt gat gtg gcc tgc gga atc 1027 Gly Thr Leu Thr Gln Asn Glu Ile Tyr Phe Asp Val Ala Cys Gly Ile     295 300 305 acc gtg ttg ctt ctt gcc gga cgg ctg ctg aca agg cgt cga agc caa 1075 Thr Val Leu Leu Leu Ala Gly Arg Leu Leu Thr Arg Arg Arg Ser Gln 310 315 320 325 tcc agt ttg tta gcg gaa ctt ggt cgc ctc caa atc gat cca cag cgc 1123 Ser Ser Leu Leu Ala Glu Leu Gly Arg Leu Gln Ile Asp Pro Gln Arg                 330 335 340 att gtc act gtg gtg cgt aaa cac cga ttg aag cgc gta gtc cag gaa 1171 Ile Val Thr Val Val Arg Lys His Arg Leu Lys Arg Val Val Gln Glu             345 350 355 ctg aac att cca gtg cag gaa gtc cgt gtc aat gac gat gtg aaa gtt 1219 Leu Asn Ile Pro Val Gln Glu Val Arg Val Asn Asp Asp Val Lys Val         360 365 370 cca cct aat acc acg atc cct gtg gat ggc act gtc atc ggt ggc ggt 1267 Pro Pro Asn Thr Thr Ile Pro Val Asp Gly Thr Val Ile Gly Gly Gly     375 380 385 tcg cgg atc gca gct agc atc atc atg gga caa gac cag cgt gat gta 1315 Ser Arg Ile Ala Ala Ser Ile Ile Met Gly Gln Asp Gln Arg Asp Val 390 395 400 405 aaa gta aat gac aaa gtt ttc gcc ggc agc ctc aac ctc gaa tcc gaa 1363 Lys Val Asn Asp Lys Val Phe Ala Gly Ser Leu Asn Leu Glu Ser Glu                 410 415 420 atc aag gtt cgt gtt att cgc act ggt cac cgc acc cgc atc gcc gcg 1411 Ile Lys Val Arg Val Ile Arg Thr Gly His Arg Thr Arg Ile Ala Ala             425 430 435 gta cat agg tgg gtt aaa gaa gcg acg ttg aag gaa aac cgc cac aat 1459 Val His Arg Trp Val Lys Glu Ala Thr Leu Lys Glu Asn Arg His Asn         440 445 450 agg gca gcg atc cgt tcg gcc ggt aac ctt gtg ccc atc acg ttc acc 1507 Arg Ala Ala Ile Arg Ser Ala Gly Asn Leu Val Pro Ile Thr Phe Thr     455 460 465 ctt gct gtg gtg gac ttc tgt ctg tgg gca ctg atc tct gga aac atc 1555 Leu Ala Val Val Asp Phe Cys Leu Trp Ala Leu Ile Ser Gly Asn Ile 470 475 480 485 aac gct gca ttt acc act acc ttg gct gtc ctt gcg tgc gtg gct ccg 1603 Asn Ala Ala Phe Thr Thr Thr Leu Ala Val Leu Ala Cys Val Ala Pro                 490 495 500 gtg gcc tta gcg ttg tct gct cca ctt gcc acg agg aat tcc atc gaa 1651 Val Ala Leu Ala Leu Ser Ala Pro Leu Ala Thr Arg Asn Ser Ile Glu             505 510 515 gct gca gca cga cac ggt att ttg gtc cgc tct ggt gaa att ttc cga 1699 Ala Ala Ala Arg His Gly Ile Leu Val Arg Ser Gly Glu Ile Phe Arg         520 525 530 gtt ctc gat gat gtg gat act gcc gta ttt aat cgt gtg ggc aca cta 1747 Val Leu Asp Asp Val Asp Thr Ala Val Phe Asn Arg Val Gly Thr Leu     535 540 545 acc gat ggc gaa atg aca gtg gaa acc gtc aca gca gac aaa ggc gag 1795 Thr Asp Gly Glu Met Thr Val Glu Thr Val Thr Ala Asp Lys Gly Glu 550 555 560 565 gac cca gaa cta gtg ctg cgt gtc gcc ggg gcg ttg gcc atg gaa tcc 1843 Asp Pro Glu Leu Val Leu Arg Val Ala Gly Ala Leu Ala Met Glu Ser                 570 575 580 cac cac gcg att tcc aaa gca ctg gtg aaa gca tcc cgt gaa gct cgt 1891 His His Ala Ile Ser Lys Ala Leu Val Lys Ala Ser Arg Glu Ala Arg             585 590 595 gat acc ggc gcc ggt ggt gaa gat gtc cca cac tgg att gaa gta ggc 1939 Asp Thr Gly Ala Gly Gly Glu Asp Val Pro His Trp Ile Glu Val Gly         600 605 610 aac gtg gaa atc acc gaa gcc ggc tca ttc caa gca acc atc gag ctg 1987 Asn Val Glu Ile Thr Glu Ala Gly Ser Phe Gln Ala Thr Ile Glu Leu     615 620 625 cca ctg atc aaa cca tct ggc gaa aaa atc atg cgc acc aca gaa gca 2035 Pro Leu Ile Lys Pro Ser Gly Glu Lys Ile Met Arg Thr Thr Glu Ala 630 635 640 645 ctc ctg tgg cga cca cga tcc atg aca gaa gtc cgt gag cac tta agc 2083 Leu Leu Trp Arg Pro Arg Ser Met Thr Glu Val Arg Glu His Leu Ser                 650 655 660 ccc cga cta gtg gca gca gca acc tca ggt ggc gca cca ctg atc gtg 2131 Pro Arg Leu Val Ala Ala Ala Thr Ser Gly Gly Ala Pro Leu Ile Val             665 670 675 cga tgg aaa ggc aaa gac cgc gga gtt atc act cta agt gac cac gtg 2179 Arg Trp Lys Gly Lys Asp Arg Gly Val Ile Thr Leu Ser Asp His Val         680 685 690 aga tca gat tcc tcc gat gcg att att gcg att gaa gaa caa ggc atc 2227 Arg Ser Asp Ser Ser Asp Ala Ile Ile Ala Ile Glu Glu Gln Gly Ile     695 700 705 gag acc atg atg ctt tca cgt gat act tac ccg gtg gca cgt cga tac 2275 Glu Thr Met Met Leu Ser Arg Asp Thr Tyr Pro Val Ala Arg Arg Tyr 710 715 720 725 gca gac agc tta ggc atc acc cac gtc ttg gcc ggc atc gcg ccg ggc 2323 Ala Asp Ser Leu Gly Ile Thr His Val Leu Ala Gly Ile Ala Pro Gly                 730 735 740 aag aaa gcc cag gtc gtc cgt gca gtc cac acc cgc gga tcc act gtc 2371 Lys Lys Ala Gln Val Val Arg Ala Val His Thr Arg Gly Ser Thr Val             745 750 755 gcg atg atc ggc gat gaa tca gta atg gac tgt ttg aaa gtc gct gac 2419 Ala Met Ile Gly Asp Glu Ser Val Met Asp Cys Leu Lys Val Ala Asp         760 765 770 gtg ggt gta ctg atg ggc gtc gat cgt ccc tca gat ctg cgt gat gat 2467 Val Gly Val Leu Met Gly Val Asp Arg Pro Ser Asp Leu Arg Asp Asp     775 780 785 tcc gat gac ccg gca gct gac gtt gtg gtc atg cgc gaa gag gtc atg 2515 Ser Asp Asp Pro Ala Ala Asp Val Val Val Met Arg Glu Glu Val Met 790 795 800 805 agc gtg ccg acg ctg ttt aaa ctg gct cga cgc tac gcc aag ttg gtc 2563 Ser Val Pro Thr Leu Phe Lys Leu Ala Arg Arg Tyr Ala Lys Leu Val                 810 815 820 aat ggc aat att gct ctg gcc tgg atc tat aac ggt gtt gcc atg gtg 2611 Asn Gly Asn Ile Ala Leu Ala Trp Ile Tyr Asn Gly Val Ala Met Val             825 830 835 ctt gca gtg tct ggc ttg ctg cat cca atg gct gcg acc gtg gct atg 2659 Leu Ala Val Ser Gly Leu Leu His Pro Met Ala Ala Thr Val Ala Met         840 845 850 ctg gcg tct tcg ctg ctt att gaa tgg cgc tcg ggc agg gcg cgc aag 2707 Leu Ala Ser Ser Leu Leu Ile Glu Trp Arg Ser Gly Arg Ala Arg Lys     855 860 865 tac taaccagcaa ttcccaagcc caa 2733 Tyr 870 <210> 578 <211> 870 <212> PRT <213> Corynebacterium glutamicum <400> 578 Val Asp Lys Ala Val Asn Thr Ala Ile Ser Asp Ala Lys Thr Ala Ala   1 5 10 15 Leu Lys Ala Gly Val Gly Leu Asn Arg Ala Thr Ala Ser Glu Glu Glu              20 25 30 Glu Asp Leu Ser Ser Ser Ile Lys Val Ser Leu Ala Phe Glu Leu Glu          35 40 45 Gly Leu Ser Asn Ala Pro Ser Leu Met Val Val Glu Lys Ala Leu Glu      50 55 60 Lys Ile Pro Gly Val Ser Ala Asp Leu Ile Tyr Pro Ser Gln Thr Ala  65 70 75 80 Trp Ile Thr Ala Thr Asp Arg Val His Pro Glu Thr Leu Ile Glu Val                  85 90 95 Phe Glu Gln Phe Gly Ile Lys Ala His Leu Ser Asn Ser Ser Leu Leu             100 105 110 Arg Arg His Gln Gln Leu Ser Ala Glu Val Asn Arg Glu Ala Arg Leu         115 120 125 Asp Arg Tyr Arg Ser Arg Met Asp Ala Lys Arg Ile Ser Pro Arg Val     130 135 140 Arg Arg His Asn Arg Gln Glu Met Val His Ala Val Arg Ala Arg Glu 145 150 155 160 Ser Gly Trp Ile Lys Arg Arg Asn His Thr Thr Ser Ser Gln His Glu Asp                 165 170 175 Pro Met Ser Gly Asp Val Leu Phe Thr Ala Arg Ala Leu Ile Thr Pro             180 185 190 Lys Arg Leu Trp Val Ser Leu Pro Phe Ala Leu Ile Val Leu Ala Leu         195 200 205 Ser Leu Asn Pro Ser Trp Gln Phe Asp Tyr Trp Gln Trp Leu Ser Ala     210 215 220 Val Leu Ala Ile Pro Val Val Val Trp Gly Ala Trp Pro Phe His Arg 225 230 235 240 Ala Ala Ala Gly Gly Ile Arg Arg Gly Ile Ser Ala Leu Asp Ala Thr                 245 250 255 Ser Ser Ile Ala Ile Ala Ala Ala Tyr Ala Trp Ser Ile Ala Met Leu             260 265 270 Leu Phe Glu Thr Pro Gly Gly Lys Ser Trp Arg Ser Tyr Pro Ser Trp         275 280 285 Phe Ala Phe Asp His Gly Thr Leu Thr Gln Asn Glu Ile Tyr Phe Asp     290 295 300 Val Ala Cys Gly Ile Thr Val Leu Leu Leu Ala Gly Arg Leu Leu Thr 305 310 315 320 Arg Arg Arg Ser Gln Ser Ser Leu Leu Ala Glu Leu Gly Arg Leu Gln                 325 330 335 Ile Asp Pro Gln Arg Ile Val Thr Val Val Arg Lys His Arg Leu Lys             340 345 350 Arg Val Val Gln Glu Leu Asn Ile Pro Val Gln Glu Val Arg Val Asn         355 360 365 Asp Asp Val Lys Val Pro Pro Asn Thr Thr Ile Pro Val Asp Gly Thr     370 375 380 Val Ile Gly Gly Gly Ser Arg Ile Ala Ala Ser Ile Ile Met Gly Gln 385 390 395 400 Asp Gln Arg Asp Val Lys Val Asn Asp Lys Val Phe Ala Gly Ser Leu                 405 410 415 Asn Leu Glu Ser Glu Ile Lys Val Arg Val Ile Arg Thr Gly His Arg             420 425 430 Thr Arg Ile Ala Ala Val His Arg Trp Val Lys Glu Ala Thr Leu Lys         435 440 445 Glu Asn Arg His Asn Arg Ala Ala Ile Arg Ser Ala Gly Asn Leu Val     450 455 460 Pro Ile Thr Phe Thr Leu Ala Val Val Asp Phe Cys Leu Trp Ala Leu 465 470 475 480 Ile Ser Gly Asn Ile Asn Ala Ala Phe Thr Thr Thr Leu Ala Val Leu                 485 490 495 Ala Cys Val Ala Pro Val Ala Leu Ala Leu Ser Ala Pro Leu Ala Thr             500 505 510 Arg Asn Ser Ile Glu Ala Ala Ala Arg His Gly Ile Leu Val Arg Ser         515 520 525 Gly Glu Ile Phe Arg Val Leu Asp Asp Val Asp Thr Ala Val Phe Asn     530 535 540 Arg Val Gly Thr Leu Thr Asp Gly Glu Met Thr Val Glu Thr Val Thr 545 550 555 560 Ala Asp Lys Gly Glu Asp Pro Glu Leu Val Leu Arg Val Ala Gly Ala                 565 570 575 Leu Ala Met Glu Ser His His Ala Ile Ser Lys Ala Leu Val Lys Ala             580 585 590 Ser Arg Glu Ala Arg Asp Thr Gly Ala Gly Gly Glu Asp Val Pro His         595 600 605 Trp Ile Glu Val Gly Asn Val Glu Ile Thr Glu Ala Gly Ser Phe Gln     610 615 620 Ala Thr Ile Glu Leu Pro Leu Ile Lys Pro Ser Gly Glu Lys Ile Met 625 630 635 640 Arg Thr Thr Glu Ala Leu Leu Trp Arg Pro Arg Ser Met Thr Glu Val                 645 650 655 Arg Glu His Leu Ser Pro Arg Leu Val Ala Ala Ala Thr Ser Gly Gly             660 665 670 Ala Pro Leu Ile Val Arg Trp Lys Gly Lys Asp Arg Gly Val Ile Thr         675 680 685 Leu Ser Asp His Val Arg Ser Asp Ser Ser Asp Ala Ile Ila Ala Ile     690 695 700 Glu Glu Gln Gly Ile Glu Thr Met Met Leu Ser Arg Asp Thr Tyr Pro 705 710 715 720 Val Ala Arg Arg Tyr Ala Asp Ser Leu Gly Ile Thr His Val Leu Ala                 725 730 735 Gly Ile Ala Pro Gly Lys Lys Ala Gln Val Val Arg Ala Val His Thr             740 745 750 Arg Gly Ser Thr Val Ala Met Ile Gly Asp Glu Ser Val Met Asp Cys         755 760 765 Leu Lys Val Ala Asp Val Gly Val Leu Met Gly Val Asp Arg Pro Ser     770 775 780 Asp Leu Arg Asp Asp Ser Asp Asp Pro Ala Ala Asp Val Val Val Met 785 790 795 800 Arg Glu Glu Val Met Ser Val Pro Thr Leu Phe Lys Leu Ala Arg Arg                 805 810 815 Tyr Ala Lys Leu Val Asn Gly Asn Ile Ala Leu Ala Trp Ile Tyr Asn             820 825 830 Gly Val Ala Met Val Leu Ala Val Ser Gly Leu Leu His Pro Met Ala         835 840 845 Ala Thr Val Ala Met Leu Ala Ser Ser Leu Leu Ile Glu Trp Arg Ser     850 855 860 Gly Arg Ala Arg Lys Tyr 865 870 <210> 579 <211> 1925 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (1902) <223> RXN01338 <400> 579 aaa act tat acc cca aat ccc tgg atg tta ttc atc cgc tca ttt gat 48 Lys Thr Tyr Thr Pro Asn Pro Trp Met Leu Phe Ile Arg Ser Phe Asp   1 5 10 15 ggc atc atc act gtc gca gcc ctt gtt gcc atc gca ata cat ctc att 96 Gly Ile Ile Thr Val Ala Ala Leu Val Ala Ile Ala Ile His Leu Ile              20 25 30 tta tgg ctg gct cta gat cta gat ggc ctt gct aaa aac tgg cct tta 144 Leu Trp Leu Ala Leu Asp Leu Asp Gly Leu Ala Lys Asn Trp Pro Leu          35 40 45 ata gcc atc gtt atc gta ggt ggc att ccg ttg atg tgg gat gtg ctg 192 Ile Ala Ile Val Ile Val Gly Gly Ile Pro Leu Met Trp Asp Val Leu      50 55 60 aaa tca gcc att aaa act cgc ggt ggc gcg gat act tta gca gca gtc 240 Lys Ser Ala Ile Lys Thr Arg Gly Gly Ala Asp Thr Leu Ala Ala Val  65 70 75 80 tcc atc att act tct gtg ttg tta ggg gag tgg ttg gtt gcc gcg atc 288 Ser Ile Ile Thr Ser Val Leu Leu Gly Glu Trp Leu Val Ala Ala Ile                  85 90 95 atc gtg ctc atg ctc tct ggt ggt gaa gcg cta gaa gag gca gca tca 336 Ile Val Leu Met Leu Ser Gly Gly Glu Ala Leu Glu Glu Ala Ala Ser             100 105 110 cgg cga gcc agt ggc acc ttg gac gca ctt gcc cgg cgc gca cca agt 384 Arg Arg Ala Ser Gly Thr Leu Asp Ala Leu Ala Arg Arg Ala Pro Ser         115 120 125 aca gct cac cgc ctg ttg ggt gca acc att ctt gat gga acc gaa gag 432 Thr Ala His Arg Leu Leu Gly Ala Thr Ile Leu Asp Gly Thr Glu Glu     130 135 140 atc gcc gtg gaa gag atc acg gtt ggt gat tta gtg gcg gtg ctc ccg 480 Ile Ala Val Glu Glu Ile Thr Val Gly Asp Leu Val Ala Val Leu Pro 145 150 155 160 cat gaa ctt tgt ccc gtg gat ggt gaa atc gtg gca ggc cac ggc acc 528 His Glu Leu Cys Pro Val Asp Gly Glu Ile Val Ala Gly His Gly Thr                 165 170 175 atg gat gag tct tat ctc acg ggt gag ccc tat gtg gtg agt aaa tct 576 Met Asp Glu Ser Tyr Leu Thr Gly Glu Pro Tyr Val Val Ser Lys Ser             180 185 190 aaa ggt tcg caa gca atg tcg ggt gca gtc aat ggt gat act ccg ctg 624 Lys Gly Ser Gln Ala Met Ser Gly Ala Val Asn Gly Asp Thr Pro Leu         195 200 205 acg att gtt gcc aca aag ctt gcc cat gat tcc aga tac gcc caa att 672 Thr Ile Val Ala Thr Lys Leu Ala His Asp Ser Arg Tyr Ala Gln Ile     210 215 220 gtt ggt gta ctc cat gaa gca gaa aac aac cgc cca gaa atg cgc agg 720 Val Gly Val Leu His Glu Ala Glu Asn Asn Arg Pro Glu Met Arg Arg 225 230 235 240 atg gct gac cgt ctt ggc gcg tgg tat acg gtg att gca ctt gcc ctc 768 Met Ala Asp Arg Leu Gly Ala Trp Tyr Thr Val Ile Ala Leu Ala Leu                 245 250 255 ggt ggt ctt ggc tgg att gtc tcc ggc gac cca gtg agg ttc ttg gct 816 Gly Gly Leu Gly Trp Ile Val Ser Gly Asp Pro Val Arg Phe Leu Ala             260 265 270 gtt gtc gtt gtc gcc acc cca tgt cca ttg ctc att gca gtg cca gtg 864 Val Val Val Val Ala Thr Pro Cys Pro Leu Leu Ile Ala Val Pro Val         275 280 285 gcg atc atc ggt gcg att tct ctt gcg gct cgt cgg ggc atc atc gtg 912 Ala Ile Ile Gly Ala Ile Ser Leu Ala Ala Arg Arg Gly Ile Ile Val     290 295 300 aag aac cct gga atg ctg gaa aac gct tca gga gta aag aca gtg atg 960 Lys Asn Pro Gly Met Leu Glu Asn Ala Ser Gly Val Lys Thr Val Met 305 310 315 320 ttc gat aag act gga acg ctc acc tat ggc agg cca gtg att act gat 1008 Phe Asp Lys Thr Gly Thr Leu Thr Tyr Gly Arg Pro Val Ile Thr Asp                 325 330 335 atc cac act gct ccc gga gtt gag gaa gat aca gtc cta gct ttg gct 1056 Ile His Thr Ala Pro Gly Val Glu Glu Asp Thr Val Leu Ala Leu Ala             340 345 350 gct tca gta gag cgc tac tcc aga cac ccg ttg gct gac gcg att cgt 1104 Ala Ser Val Glu Arg Tyr Ser Arg His Pro Leu Ala Asp Ala Ile Arg         355 360 365 gag ggc gca aaa gcc agg gaa ctt cat ctg cct gat gta gtg gaa gta 1152 Glu Gly Ala Lys Ala Arg Glu Leu His Leu Pro Asp Val Val Glu Val     370 375 380 tcg gaa cgt cca gga cag gga cta acc ggc acg gtg ggc gag cac ctg 1200 Ser Glu Arg Pro Gly Gln Gly Leu Thr Gly Thr Val Gly Glu His Leu 385 390 395 400 gtt cga ata acc aat agg cgc agc aca cta gaa att gat cca gac agc 1248 Val Arg Ile Thr Asn Arg Arg Ser Thr Leu Glu Ile Asp Pro Asp Ser                 405 410 415 aag aac tac att ccg gtg aca agt tcc ggc atg gaa tct gtg gtg ctt 1296 Lys Asn Tyr Ile Pro Val Thr Ser Ser Gly Met Glu Ser Val Val Leu             420 425 430 gtt gat gat aaa tat gca gca ctc att cgc ctc cgg gat gaa cct cgt 1344 Val Asp Asp Lys Tyr Ala Ala Leu Ile Arg Leu Arg Asp Glu Pro Arg         435 440 445 gca tct gcc agt gag ttc atc gcg cac ttg ccc aag aag cac aaa gtg 1392 Ala Ser Ala Ser Glu Phe Ile Ala His Leu Pro Lys Lys His Lys Val     450 455 460 gac aag ctc atg att atc tct ggt gat cgc gca tct gag gtt cgt tac 1440 Asp Lys Leu Met Ile Ile Ser Gly Asp Arg Ala Ser Glu Val Arg Tyr 465 470 475 480 ctt gcg gac aag gtt ggc att gat gag gta cac gca gag gcc tca ccg 1488 Leu Ala Asp Lys Val Gly Ile Asp Glu Val His Ala Glu Ala Ser Pro                 485 490 495 gaa gac aag ctg aac att gtt aat cgg cat aat gag cac ggc gcc acc 1536 Glu Asp Lys Leu Asn Ile Val Asn Arg His Asn Glu His Gly Ala Thr             500 505 510 atg ttc tta ggt gat gga atc aac gat gcg cca gcc atg gcc gtt gcc 1584 Met Phe Leu Gly Asp Gly Ile Asn Asp Ala Pro Ala Met Ala Val Ala         515 520 525 acc gtt ggt gtc gcg atg gga gca gac tcc gat gtc acg tcc gaa gca 1632 Thr Val Gly Val Ala Met Gly Ala Asp Ser Asp Val Thr Ser Glu Ala     530 535 540 gca gat gct gtg att ttg gat tct tcc ctg gaa cgt ctc gac gat ctg 1680 Ala Asp Ala Val Ile Leu Asp Ser Ser Leu Glu Arg Leu Asp Asp Leu 545 550 555 560 ctc cac atc agt gca cgg atg cgt cga ata gcg ttg caa tct gcg ggc 1728 Leu His Ile Ser Ala Arg Met Arg Arg Ile Ala Leu Gln Ser Ala Gly                 565 570 575 ggt ggc atg gcg ttg agt gtc ata gga atg atc ctc gcg gta ttt gga 1776 Gly Gly Met Ala Leu Ser Val Ile Gly Met Ile Leu Ala Val Phe Gly             580 585 590 ttc ttg acg cca ctg atg ggt gcg atc ttc caa gag gtc att gac gtg 1824 Phe Leu Thr Pro Leu Met Gly Ala Ile Phe Gln Glu Val Ile Asp Val         595 600 605 ctg gct atc ctc aat tcc gct cgg gtc gca ctg cca cgc gga gcg att 1872 Leu Ala Ile Leu Asn Ser Ala Arg Val Ala Leu Pro Arg Gly Ala Ile     610 615 620 agt gat ttt gat acg caa gaa aaa gtt tct tagcagggta acctaaatgt 1922 Ser Asp Phe Asp Thr Gln Glu Lys Val Ser 625 630 cgt 1925 <210> 580 <211> 634 <212> PRT <213> Corynebacterium glutamicum <400> 580 Lys Thr Tyr Thr Pro Asn Pro Trp Met Leu Phe Ile Arg Ser Phe Asp   1 5 10 15 Gly Ile Ile Thr Val Ala Ala Leu Val Ala Ile Ala Ile His Leu Ile              20 25 30 Leu Trp Leu Ala Leu Asp Leu Asp Gly Leu Ala Lys Asn Trp Pro Leu          35 40 45 Ile Ala Ile Val Ile Val Gly Gly Ile Pro Leu Met Trp Asp Val Leu      50 55 60 Lys Ser Ala Ile Lys Thr Arg Gly Gly Ala Asp Thr Leu Ala Ala Val  65 70 75 80 Ser Ile Ile Thr Ser Val Leu Leu Gly Glu Trp Leu Val Ala Ala Ile                  85 90 95 Ile Val Leu Met Leu Ser Gly Gly Glu Ala Leu Glu Glu Ala Ala Ser             100 105 110 Arg Arg Ala Ser Gly Thr Leu Asp Ala Leu Ala Arg Arg Ala Pro Ser         115 120 125 Thr Ala His Arg Leu Leu Gly Ala Thr Ile Leu Asp Gly Thr Glu Glu     130 135 140 Ile Ala Val Glu Glu Ile Thr Val Gly Asp Leu Val Ala Val Leu Pro 145 150 155 160 His Glu Leu Cys Pro Val Asp Gly Glu Ile Val Ala Gly His Gly Thr                 165 170 175 Met Asp Glu Ser Tyr Leu Thr Gly Glu Pro Tyr Val Val Ser Lys Ser             180 185 190 Lys Gly Ser Gln Ala Met Ser Gly Ala Val Asn Gly Asp Thr Pro Leu         195 200 205 Thr Ile Val Ala Thr Lys Leu Ala His Asp Ser Arg Tyr Ala Gln Ile     210 215 220 Val Gly Val Leu His Glu Ala Glu Asn Asn Arg Pro Glu Met Arg Arg 225 230 235 240 Met Ala Asp Arg Leu Gly Ala Trp Tyr Thr Val Ile Ala Leu Ala Leu                 245 250 255 Gly Gly Leu Gly Trp Ile Val Ser Gly Asp Pro Val Arg Phe Leu Ala             260 265 270 Val Val Val Val Ala Thr Pro Cys Pro Leu Leu Ile Ala Val Pro Val         275 280 285 Ala Ile Ile Gly Ala Ile Ser Leu Ala Ala Arg Arg Gly Ile Ile Val     290 295 300 Lys Asn Pro Gly Met Leu Glu Asn Ala Ser Gly Val Lys Thr Val Met 305 310 315 320 Phe Asp Lys Thr Gly Thr Leu Thr Tyr Gly Arg Pro Val Ile Thr Asp                 325 330 335 Ile His Thr Ala Pro Gly Val Glu Glu Asp Thr Val Leu Ala Leu Ala             340 345 350 Ala Ser Val Glu Arg Tyr Ser Arg His Pro Leu Ala Asp Ala Ile Arg         355 360 365 Glu Gly Ala Lys Ala Arg Glu Leu His Leu Pro Asp Val Val Glu Val     370 375 380 Ser Glu Arg Pro Gly Gln Gly Leu Thr Gly Thr Val Gly Glu His Leu 385 390 395 400 Val Arg Ile Thr Asn Arg Arg Ser Thr Leu Glu Ile Asp Pro Asp Ser                 405 410 415 Lys Asn Tyr Ile Pro Val Thr Ser Ser Gly Met Glu Ser Val Val Leu             420 425 430 Val Asp Asp Lys Tyr Ala Ala Leu Ile Arg Leu Arg Asp Glu Pro Arg         435 440 445 Ala Ser Ala Ser Glu Phe Ile Ala His Leu Pro Lys Lys His Lys Val     450 455 460 Asp Lys Leu Met Ile Ile Ser Gly Asp Arg Ala Ser Glu Val Arg Tyr 465 470 475 480 Leu Ala Asp Lys Val Gly Ile Asp Glu Val His Ala Glu Ala Ser Pro                 485 490 495 Glu Asp Lys Leu Asn Ile Val Asn Arg His Asn Glu His Gly Ala Thr             500 505 510 Met Phe Leu Gly Asp Gly Ile Asn Asp Ala Pro Ala Met Ala Val Ala         515 520 525 Thr Val Gly Val Ala Met Gly Ala Asp Ser Asp Val Thr Ser Glu Ala     530 535 540 Ala Asp Ala Val Ile Leu Asp Ser Ser Leu Glu Arg Leu Asp Asp Leu 545 550 555 560 Leu His Ile Ser Ala Arg Met Arg Arg Ile Ala Leu Gln Ser Ala Gly                 565 570 575 Gly Gly Met Ala Leu Ser Val Ile Gly Met Ile Leu Ala Val Phe Gly             580 585 590 Phe Leu Thr Pro Leu Met Gly Ala Ile Phe Gln Glu Val Ile Asp Val         595 600 605 Leu Ala Ile Leu Asn Ser Ala Arg Val Ala Leu Pro Arg Gly Ala Ile     610 615 620 Ser Asp Phe Asp Thr Gln Glu Lys Val Ser 625 630 <210> 581 <211> 1917 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1894) <223> RXN00980 <400> 581 agagagaaag ggagaaatca tgaaaacgtg gaagacctgg ggggtcgtcg gagcttcagg 60 cctcttgatt attttgtcgt ggttgagttc atcgagcccg atg ctg gca gat gca 115                                             Met Leu Ala Asp Ala                                               1 5 ttc atg atc gcg gct gca att gtt gca ggt tgg ccg atc gcg cag tct 163 Phe Met Ile Ala Ala Ala Ile Val Ala Gly Trp Pro Ile Ala Gln Ser                  10 15 20 gca tat caa gca ctt cgc att cga atg gtg tcg att gac tta ctg gtc 211 Ala Tyr Gln Ala Leu Arg Ile Arg Met Val Ser Ile Asp Leu Leu Val              25 30 35 gtt gtg gct gcc gtt ggt gcc atg ttc atc aac aac tat tgg gag tct 259 Val Val Ala Ala Val Gly Ala Met Phe Ile Asn Asn Tyr Trp Glu Ser          40 45 50 gcg gcg gtg acg ttc ctc ttt gcc ctt ggc aag gca ctg gaa cgc gcg 307 Ala Ala Val Thr Phe Leu Phe Ala Leu Gly Lys Ala Leu Glu Arg Ala      55 60 65 aca atg aac cgc aca cga aaa gca cta tcg gat ctg gtg gat gca gct 355 Thr Met Asn Arg Thr Arg Lys Ala Leu Ser Asp Leu Val Asp Ala Ala  70 75 80 85 cca gaa act gca aca agg ctc aac gcg gat gac tca aca gag gta gtt 403 Pro Glu Thr Ala Thr Arg Leu Asn Ala Asp Asp Ser Thr Glu Val Val                  90 95 100 gag ctg tgg gag ctt gag ccc ggt gac atc gtc ttg gta cgc aat ggc 451 Glu Leu Trp Glu Leu Glu Pro Gly Asp Ile Val Leu Val Arg Asn Gly             105 110 115 gaa caa att ccc gtc gat gga aac gtg att gcg ggt gtc ggt gga att 499 Glu Gln Ile Pro Val Asp Gly Asn Val Ile Ala Gly Val Gly Gly Ile         120 125 130 gat gaa tcc aac atc acg ggt gaa tca atg ccg gct gaa aag ggt caa 547 Asp Glu Ser Asn Ile Thr Gly Glu Ser Met Pro Ala Glu Lys Gly Gln     135 140 145 ggc tct gat gtg tat gca gga acc tgg ctg cga tct ggt gtt ttg aga 595 Gly Ser Asp Val Tyr Ala Gly Thr Trp Leu Arg Ser Gly Val Leu Arg 150 155 160 165 gtc gag gca aca gga att ggt tca gac tca act ttg gca aaa atc att 643 Val Glu Ala Thr Gly Ile Gly Ser Asp Ser Thr Leu Ala Lys Ile Ile                 170 175 180 cac cgc gtt gaa gac gcc cag gat gac aaa gcc cgc aca caa aca ttc 691 His Arg Val Glu Asp Ala Gln Asp Asp Lys Ala Arg Thr Gln Thr Phe             185 190 195 tta gag aaa ttc tct aag tgg tac acc ccg ggc gtc atg atc gcc gcc 739 Leu Glu Lys Phe Ser Lys Trp Tyr Thr Pro Gly Val Met Ile Ala Ala         200 205 210 gca gtg gtg gga ctt atc acc tgg gac gta gaa cta gca ctg acg ctc 787 Ala Val Val Gly Leu Ile Thr Trp Asp Val Glu Leu Ala Leu Thr Leu     215 220 225 tta gtg atc ggc tgc ccc ggc gcg ttg gtt atc tcc atc ccg gtg tcc 835 Leu Val Ile Gly Cys Pro Gly Ala Leu Val Ile Ser Ile Pro Val Ser 230 235 240 245 atc gtc gca ggc atc ggc cgt gct gca cgc gat ggc gtg ctg atc aag 883 Ile Val Ala Gly Ile Gly Arg Ala Ala Arg Asp Gly Val Leu Ile Lys                 250 255 260 ggt gga gaa tac cta gaa acc gcc gcg aaa gtc gac gtc gtt gtc gtg 931 Gly Gly Glu Tyr Leu Glu Thr Ala Ala Lys Val Asp Val Val Val Val             265 270 275 gac aaa act gga acg ctg acc acc ggc cgc cca gaa ctc aca gac gta 979 Asp Lys Thr Gly Thr Leu Thr Thr Gly Arg Pro Glu Leu Thr Asp Val         280 285 290 gaa gtc atc gag ccc gcc tac agc cag ggc gag gtg ctg gag ctc gcc 1027 Glu Val Ile Glu Pro Ala Tyr Ser Gln Gly Glu Val Leu Glu Leu Ala     295 300 305 gcg cgc gcc gag acg gct tca gaa cat ccg ctt gcc gac gcc atc atc 1075 Ala Arg Ala Glu Thr Ala Ser Glu His Pro Leu Ala Asp Ala Ile Ile 310 315 320 325 cgt ggt gcc cag gat cgg ggg ctg tcc aca aca ttg gtg gaa gca gct 1123 Arg Gly Ala Gln Asp Arg Gly Leu Ser Thr Thr Leu Val Glu Ala Ala                 330 335 340 gaa aac atc acc ggc cga ggc att atc gca aat gtt gat gga cag gca 1171 Glu Asn Ile Thr Gly Arg Gly Ile Ile Ala Asn Val Asp Gly Gln Ala             345 350 355 gtt gct gtt gga tct gct gag tta ctt gat cat gaa cca gac tcg acc 1219 Val Ala Val Gly Ser Ala Glu Leu Leu Asp His Glu Pro Asp Ser Thr         360 365 370 agg atc ctg gag cta aat gcc gaa gga aag acc gcg atg ttt gtc gga 1267 Arg Ile Leu Glu Leu Asn Ala Glu Gly Lys Thr Ala Met Phe Val Gly     375 380 385 gtg aac gga cac gcc att gga atc gtg gcc gtc gcc gac gcc gtt cgt 1315 Val Asn Gly His Ala Ile Gly Ile Val Ala Val Ala Asp Ala Val Arg 390 395 400 405 tca gat tct gcc tca gca atc gaa tcg ctg cat aag gcg ggc att caa 1363 Ser Asp Ser Ala Ser Ala Ile Glu Ser Leu His Lys Ala Gly Ile Gln                 410 415 420 gtt gtc atg gcg act ggc gac gct cac cgc gtt gca caa aac gtg gcc 1411 Val Val Met Ala Thr Gly Asp Ala His Arg Val Ala Gln Asn Val Ala             425 430 435 tcc aag ctg gga gtg gat gaa gtc tac tca gag cta ctc cct gaa cag 1459 Ser Lys Leu Gly Val Asp Glu Val Tyr Ser Glu Leu Leu Pro Glu Gln         440 445 450 aaa tta gaa ctg gtg cgt gat ctg caa gct gcc ggc aaa acg gtc gcg 1507 Lys Leu Glu Leu Val Arg Asp Leu Gln Ala Ala Gly Lys Thr Val Ala     455 460 465 atg gtg ggt gac gga gtc aac gac acc cca gca ttg gca gct gct gat 1555 Met Val Gly Asp Gly Val Asn Asp Thr Pro Ala Leu Ala Ala Ala Asp 470 475 480 485 atc gga gta gcg atg ggc gtg gca ggt tcc cct gca gcc att gaa acc 1603 Ile Gly Val Ala Met Gly Val Ala Gly Ser Pro Ala Ala Ile Glu Thr                 490 495 500 gct gat atc gca ctc atg gcg gat cgt ctc cca cgg ctg gca cat gca 1651 Ala Asp Ile Ala Leu Met Ala Asp Arg Leu Pro Arg Leu Ala His Ala             505 510 515 gtg acc ttg gca aaa cgc acc gta aga acc atg cgc atc aat att ctg 1699 Val Thr Leu Ala Lys Arg Thr Val Arg Thr Met Arg Ile Asn Ile Leu         520 525 530 att gcg ttg gct acc gtg atg gtg tta cta gct ggc gtc cta ttt ggc 1747 Ile Ala Leu Ala Thr Val Met Val Leu Leu Ala Gly Val Leu Phe Gly     535 540 545 gga gtt acc atg tcg gtt ggc atg ctc gtt cac gaa gca agc gtg ctg 1795 Gly Val Thr Met Ser Val Gly Met Leu Val His Glu Ala Ser Val Leu 550 555 560 565 ctt gtt atc agc atc gcc atg ctg ttg ctg cgt cca aca ctt aaa gaa 1843 Leu Val Ile Ser Ile Ala Met Leu Leu Leu Arg Pro Thr Leu Lys Glu                 570 575 580 gat gct gcg caa gca agt gat att aaa cgc tcg gaa ata caa cag atc 1891 Asp Ala Ala Gln Ala Ser Asp Ile Lys Arg Ser Glu Ile Gln Gln Ile             585 590 595 gca taaccaatgg ctgggtactg atg 1917 Ala <210> 582 <211> 598 <212> PRT <213> Corynebacterium glutamicum <400> 582 Met Leu Ala Asp Ala Phe Met Ile Ala Ala Ala Ile Val Ala Gly Trp   1 5 10 15 Pro Ile Ala Gln Ser Ala Tyr Gln Ala Leu Arg Ile Arg Met Val Ser              20 25 30 Ile Asp Leu Leu Val Val Val Ala Ala Val Gly Ala Met Phe Ile Asn          35 40 45 Asn Tyr Trp Glu Ser Ala Ala Val Thr Phe Leu Phe Ala Leu Gly Lys      50 55 60 Ala Leu Glu Arg Ala Thr Met Asn Arg Thr Arg Lys Ala Leu Ser Asp  65 70 75 80 Leu Val Asp Ala Ala Pro Glu Thr Ala Thr Arg Leu Asn Ala Asp Asp                  85 90 95 Ser Thr Glu Val Val Glu Leu Trp Glu Leu Glu Pro Gly Asp Ile Val             100 105 110 Leu Val Arg Asn Gly Glu Gln Ile Pro Val Asp Gly Asn Val Ile Ala         115 120 125 Gly Val Gly Gly Ile Asp Glu Ser Asn Ile Thr Gly Glu Ser Met Pro     130 135 140 Ala Glu Lys Gly Gln Gly Ser Asp Val Tyr Ala Gly Thr Trp Leu Arg 145 150 155 160 Ser Gly Val Leu Arg Val Glu Ala Thr Gly Ile Gly Ser Asp Ser Thr                 165 170 175 Leu Ala Lys Ile Ile His Arg Val Glu Asp Ala Gln Asp Asp Lys Ala             180 185 190 Arg Thr Gln Thr Phe Leu Glu Lys Phe Ser Lys Trp Tyr Thr Pro Gly         195 200 205 Val Met Ile Ala Ala Ala Val Val Gly Leu Ile Thr Trp Asp Val Glu     210 215 220 Leu Ala Leu Thr Leu Leu Val Ile Gly Cys Pro Gly Ala Leu Val Ile 225 230 235 240 Ser Ile Pro Val Ser Ile Val Ala Gly Ile Gly Arg Ala Ala Arg Asp                 245 250 255 Gly Val Leu Ile Lys Gly Gly Glu Tyr Leu Glu Thr Ala Ala Lys Val             260 265 270 Asp Val Val Val Val Asp Lys Thr Gly Thr Leu Thr Thr Gly Arg Pro         275 280 285 Glu Leu Thr Asp Val Glu Val Ile Glu Pro Ala Tyr Ser Gln Gly Glu     290 295 300 Val Leu Glu Leu Ala Ala Arg Ala Glu Thr Ala Ser Glu His Pro Leu 305 310 315 320 Ala Asp Ala Ile Ile Arg Gly Ala Gln Asp Arg Gly Leu Ser Thr Thr                 325 330 335 Leu Val Glu Ala Ala Glu Asn Ile Thr Gly Arg Gly Ile Ile Ala Asn             340 345 350 Val Asp Gly Gln Ala Val Ala Val Gly Ser Ala Glu Leu Leu Asp His         355 360 365 Glu Pro Asp Ser Thr Arg Ile Leu Glu Leu Asn Ala Glu Gly Lys Thr     370 375 380 Ala Met Phe Val Gly Val Asn Gly His Ala Ile Gly Ile Val Ala Val 385 390 395 400 Ala Asp Ala Val Arg Ser Asp Ser Ala Ser Ala Ile Glu Ser Leu His                 405 410 415 Lys Ala Gly Ile Gln Val Val Met Ala Thr Gly Asp Ala His Arg Val             420 425 430 Ala Gln Asn Val Ala Ser Lys Leu Gly Val Asp Glu Val Tyr Ser Glu         435 440 445 Leu Leu Pro Glu Gln Lys Leu Glu Leu Val Arg Asp Leu Gln Ala Ala     450 455 460 Gly Lys Thr Val Ala Met Val Gly Asp Gly Val Asn Asp Thr Pro Ala 465 470 475 480 Leu Ala Ala Ala Asp Ile Gly Val Ala Met Gly Val Ala Gly Ser Pro                 485 490 495 Ala Ala Ile Glu Thr Ala Asp Ile Ala Leu Met Ala Asp Arg Leu Pro             500 505 510 Arg Leu Ala His Ala Val Thr Leu Ala Lys Arg Thr Val Arg Thr Met         515 520 525 Arg Ile Asn Ile Leu Ile Ala Leu Ala Thr Val Met Val Leu Leu Ala     530 535 540 Gly Val Leu Phe Gly Gly Val Thr Met Ser Val Gly Met Leu Val His 545 550 555 560 Glu Ala Ser Val Leu Leu Val Ile Ser Ile Ala Met Leu Leu Leu Arg                 565 570 575 Pro Thr Leu Lys Glu Asp Ala Ala Gln Ala Ser Asp Ile Lys Arg Ser             580 585 590 Glu Ile Gln Gln Ile Ala         595 <210> 583 <211> 1296 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (1273) <223> RXN00099 <400> 583 ctctggtgaa gaggatgttg actcgggaga ttcttccact gattcactga ttaagtggta 60 ccgcgcaaat aggtagtcgc ttgcttatag ggtcaggggc gtg aag aat cct cgc 115                                             Val Lys Asn Pro Arg                                               1 5 ctc ata gca ctg gcc gct atc atc ctg acc tcg ttc aat ctg cga aca 163 Leu Ile Ala Leu Ala Ala Ile Ile Leu Thr Ser Phe Asn Leu Arg Thr                  10 15 20 gct att act gct tta gct ccg ctg gtt tct gag att cgg gat gat tta 211 Ala Ile Thr Ala Leu Ala Pro Leu Val Ser Glu Ile Arg Asp Asp Leu              25 30 35 ggg gtt agt gct tct ctt att ggt gtg ttg ggc atg atc ccg act gct 259 Gly Val Ser Ala Ser Leu Ile Gly Val Leu Gly Met Ile Pro Thr Ala          40 45 50 atg ttc gcg gat gct gcg ttt gcg ctt ccg tcg ttg aag agg aag ttc 307 Met Phe Ala Asp Ala Ala Phe Ala Leu Pro Ser Leu Lys Arg Lys Phe      55 60 65 act act tcc caa ctg ttg atg ttt gcc atg ctg ttg act gct gcc ggt 355 Thr Thr Ser Gln Leu Leu Met Phe Ala Met Leu Leu Thr Ala Ala Gly  70 75 80 85 cag att att cgt gtc gct gga cct gct tcg ctg ttg atg gtc ggt act 403 Gln Ile Ile Arg Val Ala Gly Pro Ala Ser Leu Leu Met Val Gly Thr                  90 95 100 gtg ttc gcg atg ttt gcg atc gga gtt acc aat gtg ttg ctt ccg att 451 Val Phe Ala Met Phe Ala Ile Gly Val Thr Asn Val Leu Leu Pro Ile             105 110 115 gct gtt agg gag tat ttt ccg cgt cac gtc ggt gga atg tcg aca act 499 Ala Val Arg Glu Tyr Phe Pro Arg His Val Gly Gly Met Ser Thr Thr         120 125 130 tat ctg gtg tcg ttc cag att gtt cag gca ctt gct ccg acg ctt gcc 547 Tyr Leu Val Ser Phe Gln Ile Val Gln Ala Leu Ala Pro Thr Leu Ala     135 140 145 gtg ccg att tct cag tgg gct aca cat gtg ggg ttg acc ggt tgg agg 595 Val Pro Ile Ser Gln Trp Ala Thr His Val Gly Leu Thr Gly Trp Arg 150 155 160 165 gtg tcg ctc ggt tcg tgg gcg ctg ctg ggg ttg gtt gcg gcg att tcg 643 Val Ser Leu Gly Ser Trp Ala Leu Leu Gly Leu Val Ala Ala Ile Ser                 170 175 180 tgg att ccg ctg ttg agt ttg cag ggt gcc agg gtt gtt gcg gcg ccg 691 Trp Ile Pro Leu Leu Ser Leu Gln Gly Ala Arg Val Val Ala Ala Pro             185 190 195 tcg aag gtt tct ctt cct gtg tgg aag tct tcg gtt ggt gtg ggg ctc 739 Ser Lys Val Ser Leu Pro Val Trp Lys Ser Ser Val Gly Val Gly Leu         200 205 210 ggg ttg atg ttt ggg ttt act tcg ttt gcg acg tat atc ctc atg ggt 787 Gly Leu Met Phe Gly Phe Thr Ser Phe Ala Thr Tyr Ile Leu Met Gly     215 220 225 ttt atg ccg cag atg gta ggt gat cct cag ctc ggt gcg gtg ttg tta 835 Phe Met Pro Gln Met Val Gly Asp Pro Gln Leu Gly Ala Val Leu Leu 230 235 240 245 ggc tgg tgg tca att ttg gga ttg ccg ctg aac att ctg gga ccg tgg 883 Gly Trp Trp Ser Ile Leu Gly Leu Pro Leu Asn Ile Leu Gly Pro Trp                 250 255 260 ttg gtg acg cgt ttc act aac tgc ttc ccg atg gtt gtt atc gcc agt 931 Leu Val Thr Arg Phe Thr Asn Cys Phe Pro Met Val Val Ile Ala Ser             265 270 275 gtc atg ttt ctc atc ggt aat ggt ggg ttt tgt ttg gct ccg gat gtt 979 Val Met Phe Leu Ile Gly Asn Gly Gly Phe Cys Leu Ala Pro Asp Val         280 285 290 gcg ccg tgg ttg tgg gcg acg ttg tct ggt ctt ggt ccc ctt gcg ttc 1027 Ala Pro Trp Leu Trp Ala Thr Leu Ser Gly Leu Gly Pro Leu Ala Phe     295 300 305 ccg atg gcg ttg acg ctc att aat att cgt gct gaa act agt gct ggt 1075 Pro Met Ala Leu Thr Leu Ile Asn Ile Arg Ala Glu Thr Ser Ala Gly 310 315 320 325 gct tct gcg ttg agt tcc ttc ggg cag ggt ttg ggt tat acg att gcg 1123 Ala Ser Ala Leu Ser Ser Phe Gly Gln Gly Leu Gly Tyr Thr Ile Ala                 330 335 340 tgt ttc ggt ccc ttg ttg act ggt ttc att gtc gat gcg aca ggc agc 1171 Cys Phe Gly Pro Leu Leu Thr Gly Phe Ile Val Asp Ala Thr Gly Ser             345 350 355 ttc cga aca atc ttt gtg ctt ttt gcg gtt gca aca ctc ttc gtt att 1219 Phe Arg Thr Ile Phe Val Leu Phe Ala Val Ala Thr Leu Phe Val Ile         360 365 370 aga ggc ggt tac ttt gcg aca agg cag gtt tac gtc gaa aag ctt tta 1267 Arg Gly Gly Tyr Phe Ala Thr Arg Gln Val Tyr Val Glu Lys Leu Leu     375 380 385 aat cgc taggatggcg ctatgccgca aag 1296 Asn arg 390 <210> 584 <211> 391 <212> PRT <213> Corynebacterium glutamicum <400> 584 Val Lys Asn Pro Arg Leu Ile Ala Leu Ala Ala Ile Ile Leu Thr Ser   1 5 10 15 Phe Asn Leu Arg Thr Ala Ile Thr Ala Leu Ala Pro Leu Val Ser Glu              20 25 30 Ile Arg Asp Asp Leu Gly Val Ser Ala Ser Leu Ile Gly Val Leu Gly          35 40 45 Met Ile Pro Thr Ala Met Phe Ala Asp Ala Ala Phe Ala Leu Pro Ser      50 55 60 Leu Lys Arg Lys Phe Thr Thr Ser Gln Leu Leu Met Phe Ala Met Leu  65 70 75 80 Leu Thr Ala Ala Gly Gln Ile Ile Arg Val Ala Gly Pro Ala Ser Leu                  85 90 95 Leu Met Val Gly Thr Val Phe Ala Met Phe Ala Ile Gly Val Thr Asn             100 105 110 Val Leu Leu Pro Ile Ala Val Arg Glu Tyr Phe Pro Arg His Val Gly         115 120 125 Gly Met Ser Thr Thr Tyr Leu Val Ser Phe Gln Ile Val Gln Ala Leu     130 135 140 Ala Pro Thr Leu Ala Val Pro Ile Ser Gln Trp Ala Thr His Val Gly 145 150 155 160 Leu Thr Gly Trp Arg Val Ser Leu Gly Ser Trp Ala Leu Leu Gly Leu                 165 170 175 Val Ala Ala Ile Ser Trp Ile Pro Leu Leu Ser Leu Gln Gly Ala Arg             180 185 190 Val Val Ala Ala Pro Ser Lys Val Ser Leu Pro Val Trp Lys Ser Ser         195 200 205 Val Gly Val Gly Leu Gly Leu Met Phe Gly Phe Thr Ser Phe Ala Thr     210 215 220 Tyr Ile Leu Met Gly Phe Met Pro Gln Met Val Gly Asp Pro Gln Leu 225 230 235 240 Gly Ala Val Leu Leu Gly Trp Trp Ser Ile Leu Gly Leu Pro Leu Asn                 245 250 255 Ile Leu Gly Pro Trp Leu Val Thr Arg Phe Thr Asn Cys Phe Pro Met             260 265 270 Val Val Ile Ala Ser Val Met Phe Leu Ile Gly Asn Gly Gly Phe Cys         275 280 285 Leu Ala Pro Asp Val Ala Pro Trp Leu Trp Ala Thr Leu Ser Gly Leu     290 295 300 Gly Pro Leu Ala Phe Pro Met Ala Leu Thr Leu Ile Asn Ile Arg Ala 305 310 315 320 Glu Thr Ser Ala Gly Ala Ser Ala Leu Ser Ser Phe Gly Gln Gly Leu                 325 330 335 Gly Tyr Thr Ile Ala Cys Phe Gly Pro Leu Leu Thr Gly Phe Ile Val             340 345 350 Asp Ala Thr Gly Ser Phe Arg Thr Ile Phe Val Leu Phe Ala Val Ala         355 360 365 Thr Leu Phe Val Ile Arg Gly Gly Tyr Phe Ala Thr Arg Gln Val Tyr     370 375 380 Val Glu Lys Leu Leu Asn Arg 385 390 <210> 585 <211> 387 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (364) <223> RXN02662 <400> 585 ccaaggtgtc accctcaccg ttgccatcgc cttcatcatc gtcaatatcg ccgtggacct 60 gctctacgtc ctggtcaatc cacgtattag gagcatctag atg cgc cgt aaa cta 115                                             Met Arg Arg Lys Leu                                               1 5 acc acc aca tta gaa aac aag ccc ggt gca cga ctt ggt ggc ttc cgc 163 Thr Thr Thr Leu Glu Asn Lys Pro Gly Ala Arg Leu Gly Gly Phe Arg                  10 15 20 gca ctt gca cca act tca aaa atc gcg ctg gtt ttc ctt ctc ctg atc 211 Ala Leu Ala Pro Thr Ser Lys Ile Ala Leu Val Phe Leu Leu Leu Ile              25 30 35 ttc ctc ctc gcg atc ttt gcc cca ctg att gct aaa tac gat cca ctg 259 Phe Leu Leu Ala Ile Phe Ala Pro Leu Ile Ala Lys Tyr Asp Pro Leu          40 45 50 gcc tcc gga act cca gtc cag cct cca agc ggt gag cac tgg ttt ggt 307 Ala Ser Gly Thr Pro Val Gln Pro Pro Ser Gly Glu His Trp Phe Gly      55 60 65 acc gac gcc atc ggc cgc gat att ttc tcc cgc gta gcc acg gcg cca 355 Thr Asp Ala Ile Gly Arg Asp Ile Phe Ser Arg Val Ala Thr Ala Pro  70 75 80 85 gag cct ccc tgatcattgg tcttttcgct acg 387 Glu pro pro <210> 586 <211> 88 <212> PRT <213> Corynebacterium glutamicum <400> 586 Met Arg Arg Lys Leu Thr Thr Thr Leu Glu Asn Lys Pro Gly Ala Arg   1 5 10 15 Leu Gly Gly Phe Arg Ala Leu Ala Pro Thr Ser Lys Ile Ala Leu Val              20 25 30 Phe Leu Leu Leu Ile Phe Leu Leu Ala Ile Phe Ala Pro Leu Ile Ala          35 40 45 Lys Tyr Asp Pro Leu Ala Ser Gly Thr Pro Val Gln Pro Pro Ser Gly      50 55 60 Glu His Trp Phe Gly Thr Asp Ala Ile Gly Arg Asp Ile Phe Ser Arg  65 70 75 80 Val Ala Thr Ala Pro Glu Pro Pro                  85 <210> 587 <211> 972 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (949) <223> RXN02442 <400> 587 gccgtgatgt tgttgagcgc gatgtgattg ccgtatgtgc atgtgagatt ccggacgctg 60 agttctgcca ttccttaatg ataacggtta tcattttcaa atg aag ttt ttt act 115                                             Met Lys Phe Phe Thr                                               1 5 gac gcc ctc ata gtg cct ttt gac gtt tca ttc atc tcc cgc gcc ctg 163 Asp Ala Leu Ile Val Pro Phe Asp Val Ser Phe Ile Ser Arg Ala Leu                  10 15 20 gtc gcc gga tgc ctg gcc gca att tta tgc tca ctc att gga acg tgg 211 Val Ala Gly Cys Leu Ala Ala Ile Leu Cys Ser Leu Ile Gly Thr Trp              25 30 35 gtt att ttg cgc agg cta acc ttt ttc ggc gac gct atg tcg cac ggc 259 Val Ile Leu Arg Arg Leu Thr Phe Phe Gly Asp Ala Met Ser His Gly          40 45 50 ttg ctc ccc gga gta gcc acg gca tca cta ttg ggc gga aat ctc atg 307 Leu Leu Pro Gly Val Ala Thr Ala Ser Leu Leu Gly Gly Asn Leu Met      55 60 65 ttc ggc gca gca atc agc gca tta atc atg tca gcc gga gtg gtg tgg 355 Phe Gly Ala Ala Ile Ser Ala Leu Ile Met Ser Ala Gly Val Val Trp  70 75 80 85 acc agc aga aaa tcc agc ctc tcc caa gac gtc agc att ggc ctg caa 403 Thr Ser Arg Lys Ser Ser Leu Ser Gln Asp Val Ser Ile Gly Leu Gln                  90 95 100 ttt att acc atg ctt tcc ctc ggc gtg gtt att gtg tcc cac tcc gat 451 Phe Ile Thr Met Leu Ser Leu Gly Val Val Ile Val Ser His Ser Asp             105 110 115 tcc cac gcc gta gac ctc acc agt ttc ctt ttt gga gac att ctt ggc 499 Ser His Ala Val Asp Leu Thr Ser Phe Leu Phe Gly Asp Ile Leu Gly         120 125 130 gtg cga ccc tcg gat ata ttc atc atc gcc att gca aca gtg ttg ggt 547 Val Arg Pro Ser Asp Ile Phe Ile Ile Ala Ile Ala Thr Val Leu Gly     135 140 145 gga ttg act att ttt ctc ttc cac cga cag ttc act gca ctc gct ttc 595 Gly Leu Thr Ile Phe Leu Phe His Arg Gln Phe Thr Ala Leu Ala Phe 150 155 160 165 gac gag cgt aaa gct cac acc tta gga ctc aat ccc cgc ttt gca cac 643 Asp Glu Arg Lys Ala His Thr Leu Gly Leu Asn Pro Arg Phe Ala His                 170 175 180 cta ctc atg ctg gca ctg atc gca tta gct acg gtg gtg tcg ttt cag 691 Leu Leu Met Leu Ala Leu Ile Ala Leu Ala Thr Val Val Ser Phe Gln             185 190 195 gtg gtg gga acg ctt tta gtg ttt gga ctt ctc att ggt ccg ccc gcc 739 Val Val Gly Thr Leu Leu Val Phe Gly Leu Leu Ile Gly Pro Pro Ala         200 205 210 acg gct gca ctt tta gtg caa gac aaa gca agt att tca ctg atc atg 787 Thr Ala Ala Leu Leu Val Gln Asp Lys Ala Ser Ile Ser Leu Ile Met     215 220 225 atc gtc gcg tcg ctt ctt gga tgc gcg gaa att tac ctc ggg ctt tta 835 Ile Val Ala Ser Leu Leu Gly Cys Ala Glu Ile Tyr Leu Gly Leu Leu 230 235 240 245 atc agc tgg cac gca agc act gcc gcg gga gcc act atc act ttg tta 883 Ile Ser Trp His Ala Ser Thr Ala Ala Gly Ala Thr Ile Thr Leu Leu                 250 255 260 agt gct gcg ata ttt ttt gcc acc tta ttg aca aag agt gcc att agt 931 Ser Ala Ala Ile Phe Phe Ala Thr Leu Leu Thr Lys Ser Ala Ile Ser             265 270 275 agg tta aac ttc acc gcg tgatactgaa agacattttc aat 972 Arg Leu Asn Phe Thr Ala         280 <210> 588 <211> 283 <212> PRT <213> Corynebacterium glutamicum <400> 588 Met Lys Phe Phe Thr Asp Ala Leu Ile Val Pro Phe Asp Val Ser Phe   1 5 10 15 Ile Ser Arg Ala Leu Val Ala Gly Cys Leu Ala Ala Ile Leu Cys Ser              20 25 30 Leu Ile Gly Thr Trp Val Ile Leu Arg Arg Leu Thr Phe Phe Gly Asp          35 40 45 Ala Met Ser His Gly Leu Leu Pro Gly Val Ala Thr Ala Ser Leu Leu      50 55 60 Gly Gly Asn Leu Met Phe Gly Ala Ala Ile Ser Ala Leu Ile Met Ser  65 70 75 80 Ala Gly Val Val Trp Thr Ser Arg Lys Ser Ser Leu Ser Gln Asp Val                  85 90 95 Ser Ile Gly Leu Gln Phe Ile Thr Met Leu Ser Leu Gly Val Val Ile             100 105 110 Val Ser His Ser Asp Ser His Ala Val Asp Leu Thr Ser Phe Leu Phe         115 120 125 Gly Asp Ile Leu Gly Val Arg Pro Ser Asp Ile Phe Ile Ila Ala Ile     130 135 140 Ala Thr Val Leu Gly Gly Leu Thr Ile Phe Leu Phe His Arg Gln Phe 145 150 155 160 Thr Ala Leu Ala Phe Asp Glu Arg Lys Ala His Thr Leu Gly Leu Asn                 165 170 175 Pro Arg Phe Ala His Leu Leu Met Leu Ala Leu Ile Ala Leu Ala Thr             180 185 190 Val Val Ser Phe Gln Val Val Gly Thr Leu Leu Val Phe Gly Leu Leu         195 200 205 Ile Gly Pro Pro Ala Thr Ala Ala Leu Leu Val Gln Asp Lys Ala Ser     210 215 220 Ile Ser Leu Ile Met Ile Val Ala Ser Leu Leu Gly Cys Ala Glu Ile 225 230 235 240 Tyr Leu Gly Leu Leu Ile Ser Trp His Ala Ser Thr Ala Ala Gly Ala                 245 250 255 Thr Ile Thr Leu Leu Ser Ala Ala Ile Phe Phe Ala Thr Leu Leu Thr             260 265 270 Lys Ser Ala Ile Ser Arg Leu Asn Phe Thr Ala         275 280 <210> 589 <211> 1077 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (1054) <223> RXN02443 <400> 589 caagcactgc cgcgggagcc actatcactt tgttaagtgc tgcgatattt tttgccacct 60 tattgacaaa gagtgccatt agtaggttaa acttcaccgc gtg ata ctg aaa gac 115                                             Val Ile Leu Lys Asp                                               1 5 att ttc aat aat ggg gag ctc ttt ggg gct tcc tcc gcg aaa aat ttc 163 Ile Phe Asn Asn Gly Glu Leu Phe Gly Ala Ser Ser Ala Lys Asn Phe                  10 15 20 cga aaa cta cta gct gtt cca gcc gtt gcc gcc tca cta gct ttt ggt 211 Arg Lys Leu Leu Ala Val Pro Ala Val Ala Ala Ser Leu Ala Phe Gly              25 30 35 atc acc gcc tgt tcc gct gta gat gac acc cct gac att gtg gtc acc 259 Ile Thr Ala Cys Ser Ala Val Asp Asp Thr Pro Asp Ile Val Val Thr          40 45 50 acc aac atc ctg ggt gat gtt gta agc cat atc gtg gga gat tcc gca 307 Thr Asn Ile Leu Gly Asp Val Val Ser His Ile Val Gly Asp Ser Ala      55 60 65 gat gtc caa gta ctc atg aaa ccc aac gca gat cca cat tcc ttc gga 355 Asp Val Gln Val Leu Met Lys Pro Asn Ala Asp Pro His Ser Phe Gly  70 75 80 85 gtc tca gca caa gac gcc gct gcc atg gaa cat gcc gat ctc atc gtg 403 Val Ser Ala Gln Asp Ala Ala Ala Met Glu His Ala Asp Leu Ile Val                  90 95 100 gcc aat gga cta gga ctt gaa gag ggc ctt caa tcc aat gtg gac aat 451 Ala Asn Gly Leu Gly Leu Glu Glu Gly Leu Gln Ser Asn Val Asp Asn             105 110 115 gcc aaa agc caa ggg gtt ccc gtc ttg gaa gtc ggc gaa cac atc gat 499 Ala Lys Ser Gln Gly Val Pro Val Leu Glu Val Gly Glu His Ile Asp         120 125 130 gtc att gac tac tcc ccc ggc gtt cca gat cct cac ttt tgg aca gac 547 Val Ile Asp Tyr Ser Pro Gly Val Pro Asp Pro His Phe Trp Thr Asp     135 140 145 ccg gcg cgc atg atc gcc gcc acg gaa gtt ata gaa gct gaa ctg atc 595 Pro Ala Arg Met Ile Ala Ala Thr Glu Val Ile Glu Ala Glu Leu Ile 150 155 160 165 aaa gaa ctc gat cct tcc ctg act gaa tcg atc aca caa tca gcc cag 643 Lys Glu Leu Asp Pro Ser Leu Thr Glu Ser Ile Thr Gln Ser Ala Gln                 170 175 180 cac tac cgt gag gaa ctt gtt gcc ctt gat gag gaa gtc acc gaa ttg 691 His Tyr Arg Glu Glu Leu Val Ala Leu Asp Glu Glu Val Thr Glu Leu             185 190 195 ctc agc ggc gtg gcc cca gaa aac cgc aag ctg gta acc aat cac aat 739 Leu Ser Gly Val Ala Pro Glu Asn Arg Lys Leu Val Thr Asn His Asn         200 205 210 gtt ttt gga tac ctg gcc agc cgg ttt aac tac acc gtc att gac acc 787 Val Phe Gly Tyr Leu Ala Ser Arg Phe Asn Tyr Thr Val Ile Asp Thr     215 220 225 atc atc cca ggt gga agc aca ttg gcg gcg cct tca gca tct gac ctc 835 Ile Ile Pro Gly Gly Ser Thr Leu Ala Ala Pro Ser Ala Ser Asp Leu 230 235 240 245 aat gac atc tcc acc gcc atc gaa gac aac aat gtt ccc gca atc ttc 883 Asn Asp Ile Ser Thr Ala Ile Glu Asp Asn Asn Val Pro Ala Ile Phe                 250 255 260 acc gat acc tca agc cca caa cgg tta gct gaa gtg ttg gcc agc aac 931 Thr Asp Thr Ser Ser Pro Gln Arg Leu Ala Glu Val Leu Ala Ser Asn             265 270 275 gct ggc att gat gtt caa gtg gtg tcc att ttc acg gaa tca ctc acc 979 Ala Gly Ile Asp Val Gln Val Val Ser Ile Phe Thr Glu Ser Leu Thr         280 285 290 gat gca gat ggt gaa gca ccc acc tac atc agc atg caa aaa atc aat 1027 Asp Ala Asp Gly Glu Ala Pro Thr Tyr Ile Ser Met Gln Lys Ile Asn     295 300 305 gcc gag cgc att gca agc act ttg tcc taaacagtcc taaacagtct 1074 Ala Glu Arg Ile Ala Ser Thr Leu Ser 310 315 taa 1077 <210> 590 <211> 318 <212> PRT <213> Corynebacterium glutamicum <400> 590 Val Ile Leu Lys Asp Ile Phe Asn Asn Gly Glu Leu Phe Gly Ala Ser   1 5 10 15 Ser Ala Lys Asn Phe Arg Lys Leu Leu Ala Val Pro Ala Val Ala Ala              20 25 30 Ser Leu Ala Phe Gly Ile Thr Ala Cys Ser Ala Val Asp Asp Thr Pro          35 40 45 Asp Ile Val Val Thr Thr Asn Ile Leu Gly Asp Val Val Ser His Ile      50 55 60 Val Gly Asp Ser Ala Asp Val Gln Val Leu Met Lys Pro Asn Ala Asp  65 70 75 80 Pro His Ser Phe Gly Val Ser Ala Gln Asp Ala Ala Ala Met Glu His                  85 90 95 Ala Asp Leu Ile Val Ala Asn Gly Leu Gly Leu Glu Glu Gly Leu Gln             100 105 110 Ser Asn Val Asp Asn Ala Lys Ser Gln Gly Val Pro Val Leu Glu Val         115 120 125 Gly Glu His Ile Asp Val Ile Asp Tyr Ser Pro Gly Val Pro Asp Pro     130 135 140 His Phe Trp Thr Asp Pro Ala Arg Met Ile Ala Ala Thr Glu Val Ile 145 150 155 160 Glu Ala Glu Leu Ile Lys Glu Leu Asp Pro Ser Leu Thr Glu Ser Ile                 165 170 175 Thr Gln Ser Ala Gln His Tyr Arg Glu Glu Leu Val Ala Leu Asp Glu             180 185 190 Glu Val Thr Glu Leu Leu Ser Gly Val Ala Pro Glu Asn Arg Lys Leu         195 200 205 Val Thr Asn His Asn Val Phe Gly Tyr Leu Ala Ser Arg Phe Asn Tyr     210 215 220 Thr Val Ile Asp Thr Ile Ile Pro Gly Gly Ser Thr Leu Ala Ala Pro 225 230 235 240 Ser Ala Ser Asp Leu Asn Asp Ile Ser Thr Ala Ile Glu Asp Asn Asn                 245 250 255 Val Pro Ala Ile Phe Thr Asp Thr Ser Ser Pro Gln Arg Leu Ala Glu             260 265 270 Val Leu Ala Ser Asn Ala Gly Ile Asp Val Gln Val Val Ser Ile Phe         275 280 285 Thr Glu Ser Leu Thr Asp Ala Asp Gly Glu Ala Pro Thr Tyr Ile Ser     290 295 300 Met Gln Lys Ile Asn Ala Glu Arg Ile Ala Ser Thr Leu Ser 305 310 315 <210> 591 <211> 1323 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (1300) <223> RXN00842 <400> 591 ccttgtcgcg gaggtaagcg agggtatttc tggatgtgga acaacgcgga ttatggaaaa 60 tcgtgacttt cataacgttg agcctactaa ggtttgttcc atg att att caa atc 115                                             Met Ile Ile Gln Ile                                               1 5 cta aga gtg gca ttt gcc ttc gtc ggc atc att gtt ggc gcc ggt ttc 163 Leu Arg Val Ala Phe Ala Phe Val Gly Ile Ile Val Gly Ala Gly Phe                  10 15 20 gca tca ggg caa gag gtc atg caa tat ttt gtg gcc ttc ggc ata gac 211 Ala Ser Gly Gln Glu Val Met Gln Tyr Phe Val Ala Phe Gly Ile Asp              25 30 35 gga att tgg gga gtc att gtt tct gca gtg atc atg tcg gtg atg gcg 259 Gly Ile Trp Gly Val Ile Val Ser Ala Val Ile Met Ser Val Met Ala          40 45 50 ttg atc att ttg cag ctc gga agc tat ttc aat gca ggt gaa cac ggt 307 Leu Ile Ile Leu Gln Leu Gly Ser Tyr Phe Asn Ala Gly Glu His Gly      55 60 65 gaa gtg ttc cgc cga gta agt cac ccc gtt ttc tcc aaa att ttg gac 355 Glu Val Phe Arg Arg Val Ser His Pro Val Phe Ser Lys Ile Leu Asp  70 75 80 85 atc ggc gtt gtg gtg acg ttg ttc tcc acc ggt ttc gtc atg ttt gca 403 Ile Gly Val Val Val Thr Leu Phe Ser Thr Gly Phe Val Met Phe Ala                  90 95 100 ggc gcg gga tca aat ctg aat cag cag tgg ggg ctt ccg ctc tgg atc 451 Gly Ala Gly Ser Asn Leu Asn Gln Gln Trp Gly Leu Pro Leu Trp Ile             105 110 115 ggt tct gtg atc atg gtt ctt ctg gtg ctg gct gcg ggc atg ttg gac 499 Gly Ser Val Ile Met Val Leu Leu Val Leu Ala Ala Gly Met Leu Asp         120 125 130 gtg gat aaa gta acc aca gtc att ggt gca att act ccg ttc atc atc 547 Val Asp Lys Val Thr Thr Val Ile Gly Ala Ile Thr Pro Phe Ile Ile     135 140 145 att ttc atc act gcc gcc tcg atc tac acg ctg gta ggt aat ttc agc 595 Ile Phe Ile Thr Ala Ala Ser Ile Tyr Thr Leu Val Gly Asn Phe Ser 150 155 160 165 tca gtg gag cag ctt gat tct gct gct tta gaa gtc ggc acg acg ttg 643 Ser Val Glu Gln Leu Asp Ser Ala Ala Leu Glu Val Gly Thr Thr Leu                 170 175 180 cct cac tgg gct gtt gca gcg gtg aac tat gtg gga ttc aac ctg atg 691 Pro His Trp Ala Val Ala Ala Val Asn Tyr Val Gly Phe Asn Leu Met             185 190 195 gtt gcg gtg tcc atg gct gtg gtc att ggt gga tca atg ttt aac ccg 739 Val Ala Val Ser Met Ala Val Val Ile Gly Gly Ser Met Phe Asn Pro         200 205 210 cgg gtc gca ggt cgg ggc ggt ttg ctg ggc gga ttg atc ctg gga ttc 787 Arg Val Ala Gly Arg Gly Gly Leu Leu Gly Gly Leu Ile Leu Gly Phe     215 220 225 ttg atc atc atc agt gcg cta aca ctg ttc gcc acc gtg gaa gaa gtt 835 Leu Ile Ile Ile Ser Ala Leu Thr Leu Phe Ala Thr Val Glu Glu Val 230 235 240 245 ggc caa gat gat atg cct atg ctg acg atc atc aac aat ttg aac ccg 883 Gly Gln Asp Asp Met Pro Met Leu Thr Ile Ile Asn Asn Leu Asn Pro                 250 255 260 ctg gct ggc caa gta atg gca gtg gtt atc tac gga atg atc ttc aac 931 Leu Ala Gly Gln Val Met Ala Val Val Ile Tyr Gly Met Ile Phe Asn             265 270 275 acg gca ctg ggt atg ttc tac gca ttg ggc cgt cgt ctc act gcg aaa 979 Thr Ala Leu Gly Met Phe Tyr Ala Leu Gly Arg Arg Leu Thr Ala Lys         280 285 290 aac cca cag cga ttc cgt ccg gtt tat gtg gtc aca gtg ctg att ggt 1027 Asn Pro Gln Arg Phe Arg Pro Val Tyr Val Val Thr Val Leu Ile Gly     295 300 305 ttt gtg ttg agc ttt gtg gga ttc aag aac ttg gtg ggc tat gtg tac 1075 Phe Val Leu Ser Phe Val Gly Phe Lys Asn Leu Val Gly Tyr Val Tyr 310 315 320 325 cca gtc ttg gga tac att ggc ctg ctg ctg att gca gtg atg atg gtg 1123 Pro Val Leu Gly Tyr Ile Gly Leu Leu Leu Ile Ala Val Met Met Val                 330 335 340 gcg tgg gtg agg gga cgc gta cgc atc tac aag gaa tcc gaa cgc cgc 1171 Ala Trp Val Arg Gly Arg Val Arg Ile Tyr Lys Glu Ser Glu Arg Arg             345 350 355 atg cgg atc gca gac ttg ttg cag atc ggc cat gac gga gcg ttg agt 1219 Met Arg Ile Ala Asp Leu Leu Gln Ile Gly His Asp Gly Ala Leu Ser         360 365 370 gga gca gag ctg gcg gtg ctc aac cag gaa atc caa gat tca aac ttg 1267 Gly Ala Glu Leu Ala Val Leu Asn Gln Glu Ile Gln Asp Ser Asn Leu     375 380 385 gat gag gaa caa att aaa gca gcg gtt agg aag tagttactct gcagggacga 1320 Asp Glu Glu Gln Ile Lys Ala Ala Val Arg Lys 390 395 400 gct 1323 <210> 592 <211> 400 <212> PRT <213> Corynebacterium glutamicum <400> 592 Met Ile Ile Gln Ile Leu Arg Val Ala Phe Ala Phe Val Gly Ile Ile   1 5 10 15 Val Gly Ala Gly Phe Ala Ser Gly Gln Glu Val Met Gln Tyr Phe Val              20 25 30 Ala Phe Gly Ile Asp Gly Ile Trp Gly Val Ile Val Ser Ala Val Ile          35 40 45 Met Ser Val Met Ala Leu Ile Ile Leu Gln Leu Gly Ser Tyr Phe Asn      50 55 60 Ala Gly Glu His Gly Glu Val Phe Arg Arg Val Ser His Pro Val Phe  65 70 75 80 Ser Lys Ile Leu Asp Ile Gly Val Val Val Thr Leu Phe Ser Thr Gly                  85 90 95 Phe Val Met Phe Ala Gly Ala Gly Ser Asn Leu Asn Gln Gln Trp Gly             100 105 110 Leu Pro Leu Trp Ile Gly Ser Val Ile Met Val Leu Leu Val Leu Ala         115 120 125 Ala Gly Met Leu Asp Val Asp Lys Val Thr Thr Val Val Ile Gly Ala Ile     130 135 140 Thr Pro Phe Ile Ile Ile Phe Ile Thr Ala Ala Ser Ile Tyr Thr Leu 145 150 155 160 Val Gly Asn Phe Ser Ser Val Glu Gln Leu Asp Ser Ala Ala Leu Glu                 165 170 175 Val Gly Thr Thr Leu Pro His Trp Ala Val Ala Ala Val Asn Tyr Val             180 185 190 Gly Phe Asn Leu Met Val Ala Val Ser Met Ala Val Val Ile Gly Gly         195 200 205 Ser Met Phe Asn Pro Arg Val Ala Gly Arg Gly Gly Leu Leu Gly Gly     210 215 220 Leu Ile Leu Gly Phe Leu Ile Ile Ile Ser Ala Leu Thr Leu Phe Ala 225 230 235 240 Thr Val Glu Glu Val Gly Gln Asp Asp Met Pro Met Leu Thr Ile Ile                 245 250 255 Asn Asn Leu Asn Pro Leu Ala Gly Gln Val Met Ala Val Val Ile Tyr             260 265 270 Gly Met Ile Phe Asn Thr Ala Leu Gly Met Phe Tyr Ala Leu Gly Arg         275 280 285 Arg Leu Thr Ala Lys Asn Pro Gln Arg Phe Arg Pro Val Tyr Val Val     290 295 300 Thr Val Leu Ile Gly Phe Val Leu Ser Phe Val Gly Phe Lys Asn Leu 305 310 315 320 Val Gly Tyr Val Tyr Pro Val Leu Gly Tyr Ile Gly Leu Leu Leu Ile                 325 330 335 Ala Val Met Met Val Ala Trp Val Arg Gly Arg Val Arg Ile Tyr Lys             340 345 350 Glu Ser Glu Arg Arg Met Arg Ile Ala Asp Leu Leu Gln Ile Gly His         355 360 365 Asp Gly Ala Leu Ser Gly Ala Glu Leu Ala Val Leu Asn Gln Glu Ile     370 375 380 Gln Asp Ser Asn Leu Asp Glu Glu Gln Ile Lys Ala Ala Val Arg Lys 385 390 395 400 <210> 593 <211> 1323 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (1300) <223> FRXA00842 <400> 593 ccttgtcgcg gaggtaagcg agggtatttc tggatgtgga acaacgcgga ttatggaaaa 60 tcgtgacttt cataacgttg agcctactaa ggtttgttcc atg att att caa atc 115                                             Met Ile Ile Gln Ile                                               1 5 cta aga gtg gca ttt gcc ttc gtc ggc atc att gtt ggc gcc ggt ttc 163 Leu Arg Val Ala Phe Ala Phe Val Gly Ile Ile Val Gly Ala Gly Phe                  10 15 20 gca tca ggg caa gag gtc atg caa tat ttt gtg gcc ttc ggc ata gac 211 Ala Ser Gly Gln Glu Val Met Gln Tyr Phe Val Ala Phe Gly Ile Asp              25 30 35 gga att tgg gga gtc att gtt tct gca gtg atc atg tcg gtg atg gcg 259 Gly Ile Trp Gly Val Ile Val Ser Ala Val Ile Met Ser Val Met Ala          40 45 50 ttg atc att ttg cag ctc gga agc tat ttc aat gca ggt gaa cac ggt 307 Leu Ile Ile Leu Gln Leu Gly Ser Tyr Phe Asn Ala Gly Glu His Gly      55 60 65 gaa gtg ttc cgc cga gta agt cac ccc gtt ttc tcc aaa att ttg gac 355 Glu Val Phe Arg Arg Val Ser His Pro Val Phe Ser Lys Ile Leu Asp  70 75 80 85 atc ggc gtt gtg gtg acg ttg ttc tcc acc ggt ttc gtc atg ttt gca 403 Ile Gly Val Val Val Thr Leu Phe Ser Thr Gly Phe Val Met Phe Ala                  90 95 100 ggc gcg gga tca aat ctg aat cag cag tgg ggg ctt ccg ctc tgg atc 451 Gly Ala Gly Ser Asn Leu Asn Gln Gln Trp Gly Leu Pro Leu Trp Ile             105 110 115 ggt tct gtg atc atg gtt ctt ctg gtg ctg gct gcg ggc atg ttg gac 499 Gly Ser Val Ile Met Val Leu Leu Val Leu Ala Ala Gly Met Leu Asp         120 125 130 gtg gat aaa gta acc aca gtc att ggt gca att act ccg ttc atc atc 547 Val Asp Lys Val Thr Thr Val Ile Gly Ala Ile Thr Pro Phe Ile Ile     135 140 145 att ttc atc act gcc gcc tcg atc tac acg ctg gta ggt aat ttc agc 595 Ile Phe Ile Thr Ala Ala Ser Ile Tyr Thr Leu Val Gly Asn Phe Ser 150 155 160 165 tca gtg gag cag ctt gat tct gct gct tta gaa gtc ggc acg acg ttg 643 Ser Val Glu Gln Leu Asp Ser Ala Ala Leu Glu Val Gly Thr Thr Leu                 170 175 180 cct cac tgg gct gtt gca gcg gtg aac tat gtg gga ttc aac ctg atg 691 Pro His Trp Ala Val Ala Ala Val Asn Tyr Val Gly Phe Asn Leu Met             185 190 195 gtt gcg gtg tcc atg gct gtg gtc att ggt gga tca atg ttt aac ccg 739 Val Ala Val Ser Met Ala Val Val Ile Gly Gly Ser Met Phe Asn Pro         200 205 210 cgg gtc gca ggt cgg ggc ggt ttg ctg ggc gga ttg atc ctg gga ttc 787 Arg Val Ala Gly Arg Gly Gly Leu Leu Gly Gly Leu Ile Leu Gly Phe     215 220 225 ttg atc atc atc agt gcg cta aca ctg ttc gcc acc gtg gaa gaa gtt 835 Leu Ile Ile Ile Ser Ala Leu Thr Leu Phe Ala Thr Val Glu Glu Val 230 235 240 245 ggc caa gat gat atg cct atg ctg acg atc atc aac aat ttg aac ccg 883 Gly Gln Asp Asp Met Pro Met Leu Thr Ile Ile Asn Asn Leu Asn Pro                 250 255 260 ctg gct ggc caa gta atg gca gtg gtt atc tac gga atg atc ttc aac 931 Leu Ala Gly Gln Val Met Ala Val Val Ile Tyr Gly Met Ile Phe Asn             265 270 275 acg gca ctg ggt atg ttc tac gca ttg ggc cgt cgt ctc act gcg aaa 979 Thr Ala Leu Gly Met Phe Tyr Ala Leu Gly Arg Arg Leu Thr Ala Lys         280 285 290 aac cca cag cga ttc cgt ccg gtt tat gtg gtc aca gtg ctg att ggt 1027 Asn Pro Gln Arg Phe Arg Pro Val Tyr Val Val Thr Val Leu Ile Gly     295 300 305 ttt gtg ttg agc ttt gtg gga ttc aag aac ttg gtg ggc tat gtg tac 1075 Phe Val Leu Ser Phe Val Gly Phe Lys Asn Leu Val Gly Tyr Val Tyr 310 315 320 325 cca gtc ttg gga tac att ggc ctg ctg ctg att gca gtg atg atg gtg 1123 Pro Val Leu Gly Tyr Ile Gly Leu Leu Leu Ile Ala Val Met Met Val                 330 335 340 gcg tgg gtg agg gga cgc gta cgc atc tac aag gaa tcc gaa cgc cgc 1171 Ala Trp Val Arg Gly Arg Val Arg Ile Tyr Lys Glu Ser Glu Arg Arg             345 350 355 atg cgg atc gca gac ttg ttg cag atc ggc cat gac gga gcg ttg agt 1219 Met Arg Ile Ala Asp Leu Leu Gln Ile Gly His Asp Gly Ala Leu Ser         360 365 370 gga gca gag ctg gcg gtg ctc aac cag gaa atc caa gat tca aac ttg 1267 Gly Ala Glu Leu Ala Val Leu Asn Gln Glu Ile Gln Asp Ser Asn Leu     375 380 385 gat gag gaa caa att aaa gca gcg gtt agg aag tagttactct gcagggacga 1320 Asp Glu Glu Gln Ile Lys Ala Ala Val Arg Lys 390 395 400 gct 1323 <210> 594 <211> 400 <212> PRT <213> Corynebacterium glutamicum <400> 594 Met Ile Ile Gln Ile Leu Arg Val Ala Phe Ala Phe Val Gly Ile Ile   1 5 10 15 Val Gly Ala Gly Phe Ala Ser Gly Gln Glu Val Met Gln Tyr Phe Val              20 25 30 Ala Phe Gly Ile Asp Gly Ile Trp Gly Val Ile Val Ser Ala Val Ile          35 40 45 Met Ser Val Met Ala Leu Ile Ile Leu Gln Leu Gly Ser Tyr Phe Asn      50 55 60 Ala Gly Glu His Gly Glu Val Phe Arg Arg Val Ser His Pro Val Phe  65 70 75 80 Ser Lys Ile Leu Asp Ile Gly Val Val Val Thr Leu Phe Ser Thr Gly                  85 90 95 Phe Val Met Phe Ala Gly Ala Gly Ser Asn Leu Asn Gln Gln Trp Gly             100 105 110 Leu Pro Leu Trp Ile Gly Ser Val Ile Met Val Leu Leu Val Leu Ala         115 120 125 Ala Gly Met Leu Asp Val Asp Lys Val Thr Thr Val Val Ile Gly Ala Ile     130 135 140 Thr Pro Phe Ile Ile Ile Phe Ile Thr Ala Ala Ser Ile Tyr Thr Leu 145 150 155 160 Val Gly Asn Phe Ser Ser Val Glu Gln Leu Asp Ser Ala Ala Leu Glu                 165 170 175 Val Gly Thr Thr Leu Pro His Trp Ala Val Ala Ala Val Asn Tyr Val             180 185 190 Gly Phe Asn Leu Met Val Ala Val Ser Met Ala Val Val Ile Gly Gly         195 200 205 Ser Met Phe Asn Pro Arg Val Ala Gly Arg Gly Gly Leu Leu Gly Gly     210 215 220 Leu Ile Leu Gly Phe Leu Ile Ile Ile Ser Ala Leu Thr Leu Phe Ala 225 230 235 240 Thr Val Glu Glu Val Gly Gln Asp Asp Met Pro Met Leu Thr Ile Ile                 245 250 255 Asn Asn Leu Asn Pro Leu Ala Gly Gln Val Met Ala Val Val Ile Tyr             260 265 270 Gly Met Ile Phe Asn Thr Ala Leu Gly Met Phe Tyr Ala Leu Gly Arg         275 280 285 Arg Leu Thr Ala Lys Asn Pro Gln Arg Phe Arg Pro Val Tyr Val Val     290 295 300 Thr Val Leu Ile Gly Phe Val Leu Ser Phe Val Gly Phe Lys Asn Leu 305 310 315 320 Val Gly Tyr Val Tyr Pro Val Leu Gly Tyr Ile Gly Leu Leu Leu Ile                 325 330 335 Ala Val Met Met Val Ala Trp Val Arg Gly Arg Val Arg Ile Tyr Lys             340 345 350 Glu Ser Glu Arg Arg Met Arg Ile Ala Asp Leu Leu Gln Ile Gly His         355 360 365 Asp Gly Ala Leu Ser Gly Ala Glu Leu Ala Val Leu Asn Gln Glu Ile     370 375 380 Gln Asp Ser Asn Leu Asp Glu Glu Gln Ile Lys Ala Ala Val Arg Lys 385 390 395 400 <210> 595 <211> 1173 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (1150) <223> RXN00832 <400> 595 gagattgtgc taggttctga tgaggcttcg ggacgacccg aagaaatcta tgacagcctg 60 ggaacggccc agagttctta agaaagtttg actagagaac atg ccg ttt tct tgg 115                                             Met Pro Phe Ser Trp                                               1 5 cta aaa cca att gat tat gcc cgc atc ttt gtc ggc tgg gca tcg att 163 Leu Lys Pro Ile Asp Tyr Ala Arg Ile Phe Val Gly Trp Ala Ser Ile                  10 15 20 ttt atc atc ccc ctc atc aca ctg cca tca att att gag ttg gcg ctg 211 Phe Ile Ile Pro Leu Ile Thr Leu Pro Ser Ile Ile Glu Leu Ala Leu              25 30 35 atc gtg gca gtc atc cta ttc tgc gca ttt ggc gtg gtg aag atg gcg 259 Ile Val Ala Val Ile Leu Phe Cys Ala Phe Gly Val Val Lys Met Ala          40 45 50 gag cgt ttg gct cat att ttg ggt gat cct ttt gga tcg ttg atc ctt 307 Glu Arg Leu Ala His Ile Leu Gly Asp Pro Phe Gly Ser Leu Ile Leu      55 60 65 acc ttg tcg atc gtg atc att gaa gtg att ttg atc tgt gcg gtg atg 355 Thr Leu Ser Ile Val Ile Ile Glu Val Ile Leu Ile Cys Ala Val Met  70 75 80 85 ctg ggg cct gct gat tca acc act gct ggt cgg gat tcc gtg atg gca 403 Leu Gly Pro Ala Asp Ser Thr Thr Ala Gly Arg Asp Ser Val Met Ala                  90 95 100 gtg tcc atg atc atc atg ggt ttg gtc gtg gga ttg tgc cta ctc att 451 Val Ser Met Ile Ile Met Gly Leu Val Val Gly Leu Cys Leu Leu Ile             105 110 115 ggt ggt tta agg cat gga agc atg cca cac aat ggg gtg gga act ccg 499 Gly Gly Leu Arg His Gly Ser Met Pro His Asn Gly Val Gly Thr Pro         120 125 130 acc tac ttg gtg ctg atc gca act ttt tcc gta atc gcc ttt gcg gtt 547 Thr Tyr Leu Val Leu Ile Ala Thr Phe Ser Val Ile Ala Phe Ala Val     135 140 145 cca gct ttc agg gga gaa tac tcc act ggg cag gca ctt gtt att tca 595 Pro Ala Phe Arg Gly Glu Tyr Ser Thr Gly Gln Ala Leu Val Ile Ser 150 155 160 165 aca ctg aca gca gtg gtg tac ggg ttc ttc ctg ttt cgc caa atg ggt 643 Thr Leu Thr Ala Val Val Tyr Gly Phe Phe Leu Phe Arg Gln Met Gly                 170 175 180 gcc caa gct ggt gaa ttt caa gag gtc gag gtc gca gaa aag gca gac 691 Ala Gln Ala Gly Glu Phe Gln Glu Val Glu Val Ala Glu Lys Ala Asp             185 190 195 gac gca gca aaa tgg gag gtc cca ttt aga ggc tta atc ttg att atc 739 Asp Ala Ala Lys Trp Glu Val Pro Phe Arg Gly Leu Ile Leu Ile Ile         200 205 210 act gtg ctc ccc atc gtg ttg ctg tcc cat gac atg gcc acg gtg atg 787 Thr Val Leu Pro Ile Val Leu Leu Ser His Asp Met Ala Thr Val Met     215 220 225 gat gaa gtc ctg gca agc ctt ggt gca ccc gta gca atg gct gga tta 835 Asp Glu Val Leu Ala Ser Leu Gly Ala Pro Val Ala Met Ala Gly Leu 230 235 240 245 att att gcc acc att gtc ttc ttg cca gag acc atc acc tcc ttg aaa 883 Ile Ile Ala Thr Ile Val Phe Leu Pro Glu Thr Ile Thr Ser Leu Lys                 250 255 260 gct gcg tgg aca gga gag att cag cga gta agc aac ctc gcg cat gga 931 Ala Ala Trp Thr Gly Glu Ile Gln Arg Val Ser Asn Leu Ala His Gly             265 270 275 gcc caa gta tca acg gtg ggg ctg aca atc cca gct gtt cta gtg atc 979 Ala Gln Val Ser Thr Val Gly Leu Thr Ile Pro Ala Val Leu Val Ile         280 285 290 ggc gtg atc aca ggt caa gat gta gtt ttg ggg gag acc ccg atc aac 1027 Gly Val Ile Thr Gly Gln Asp Val Val Leu Gly Glu Thr Pro Ile Asn     295 300 305 ttg ttg ctg ctg gga acc acc att gcg gtg aca gcc att gcg ttt agc 1075 Leu Leu Leu Leu Gly Thr Thr Ile Ala Val Thr Ala Ile Ala Phe Ser 310 315 320 325 tcc aag aaa gtc agt gct gtg cat ggc tcg gtg ctg ctc atg ctt ttc 1123 Ser Lys Lys Val Ser Ala Val His Gly Ser Val Leu Leu Met Leu Phe                 330 335 340 ggt gtt tac atg atg agc atg ttc gcc tgatttaggt agcctggtgg 1170 Gly Val Tyr Met Met Ser Met Phe Ala             345 350 gaa 1173 <210> 596 <211> 350 <212> PRT <213> Corynebacterium glutamicum <400> 596 Met Pro Phe Ser Trp Leu Lys Pro Ile Asp Tyr Ala Arg Ile Phe Val   1 5 10 15 Gly Trp Ala Ser Ile Phe Ile Ile Pro Leu Ile Thr Leu Pro Ser Ile              20 25 30 Ile Glu Leu Ala Leu Ile Val Ala Val Ile Leu Phe Cys Ala Phe Gly          35 40 45 Val Val Lys Met Ala Glu Arg Leu Ala His Ile Leu Gly Asp Pro Phe      50 55 60 Gly Ser Leu Ile Leu Thr Leu Ser Ile Val Ile Ile Glu Val Ile Leu  65 70 75 80 Ile Cys Ala Val Met Leu Gly Pro Ala Asp Ser Thr Thr Ala Gly Arg                  85 90 95 Asp Ser Val Met Ala Val Ser Met Ile Met Gly Leu Val Val Gly             100 105 110 Leu Cys Leu Leu Ile Gly Gly Leu Arg His Gly Ser Met Pro His Asn         115 120 125 Gly Val Gly Thr Pro Thr Tyr Leu Val Leu Ile Ala Thr Phe Ser Val     130 135 140 Ile Ala Phe Ala Val Pro Ala Phe Arg Gly Glu Tyr Ser Thr Gly Gln 145 150 155 160 Ala Leu Val Ile Ser Thr Leu Thr Ala Val Val Tyr Gly Phe Phe Leu                 165 170 175 Phe Arg Gln Met Gly Ala Gln Ala Gly Glu Phe Gln Glu Val Glu Val             180 185 190 Ala Glu Lys Ala Asp Asp Ala Ala Lys Trp Glu Val Pro Phe Arg Gly         195 200 205 Leu Ile Leu Ile Ile Thr Val Leu Pro Ile Val Leu Leu Ser His Asp     210 215 220 Met Ala Thr Val Met Asp Glu Val Leu Ala Ser Leu Gly Ala Pro Val 225 230 235 240 Ala Met Ala Gly Leu Ile Ile Ala Thr Ile Val Phe Leu Pro Glu Thr                 245 250 255 Ile Thr Ser Leu Lys Ala Ala Trp Thr Gly Glu Ile Gln Arg Val Ser             260 265 270 Asn Leu Ala His Gly Ala Gln Val Ser Thr Val Gly Leu Thr Ile Pro         275 280 285 Ala Val Leu Val Ile Gly Val Ile Thr Gly Gln Asp Val Val Leu Gly     290 295 300 Glu Thr Pro Ile Asn Leu Leu Leu Leu Gly Thr Thr Ile Ala Val Thr 305 310 315 320 Ala Ile Ala Phe Ser Ser Lys Lys Val Ser Ala Val His Gly Ser Val                 325 330 335 Leu Leu Met Leu Phe Gly Val Tyr Met Met Ser Met Phe Ala             340 345 350 <210> 597 <211> 1119 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1096) <223> RXN00466 <400> 597 tttaaaagcg cactaagagc tcgtcaattc tttaaaacaa gctgagaatg tgaataatag 60 gataggttaa cctgattcga ttagaaaacg gagatttgtc gtg caa tcc cgc ctg 115                                             Val Gln Ser Arg Leu                                               1 5 tcc aaa atc ctg cgc agt agc gtc gta ggc gtt gct gtc cta gcc ctg 163 Ser Lys Ile Leu Arg Ser Ser Val Val Gly Val Ala Val Leu Ala Leu                  10 15 20 tta gct ggg tgt tct aac aat gca gat gac acc gac gct gat tca aca 211 Leu Ala Gly Cys Ser Asn Asn Ala Asp Asp Thr Asp Ala Asp Ser Thr              25 30 35 tcc acg gga aac tcc gct ttt cct gtt tcg att gaa cac gag ttc gga 259 Ser Thr Gly Asn Ser Ala Phe Pro Val Ser Ile Glu His Glu Phe Gly          40 45 50 acc acc aca atc gat gat gta ccc gaa aga gtt gtc acc ctt ggc gtt 307 Thr Thr Thr Ile Asp Asp Val Pro Glu Arg Val Val Thr Leu Gly Val      55 60 65 acc gac gcc gat att gtc ctc gca ttg ggg acc gtc cca gta ggc aac 355 Thr Asp Ala Asp Ile Val Leu Ala Leu Gly Thr Val Pro Val Gly Asn  70 75 80 85 acc gga tac aaa ttc ttc gaa aac gga ttg gga ccg tgg act gat gag 403 Thr Gly Tyr Lys Phe Phe Glu Asn Gly Leu Gly Pro Trp Thr Asp Glu                  90 95 100 tta gtg gaa ggc aaa gaa tta aca ctg ctt gac tct gat tcc aca cca 451 Leu Val Glu Gly Lys Glu Leu Thr Leu Leu Asp Ser Asp Ser Thr Pro             105 110 115 gat ctt gaa caa gta gca gcc ctg gag cca gac ctg att att gga gtc 499 Asp Leu Glu Gln Val Ala Ala Leu Glu Pro Asp Leu Ile Ile Gly Val         120 125 130 tct gcg ggg ttt gac gac gtt gta tac gag caa cta tct gat atc gca 547 Ser Ala Gly Phe Asp Asp Val Val Tyr Glu Gln Leu Ser Asp Ile Ala     135 140 145 ccg gtg gtc gcc cgt cca gcg gga aca gct gca tac gca gta gct cgc 595 Pro Val Val Ala Arg Pro Ala Gly Thr Ala Ala Tyr Ala Val Ala Arg 150 155 160 165 gag gaa gct acc aac ctt gtt gcc cgt gcg atg ggg caa tca gaa aaa 643 Glu Glu Ala Thr Asn Leu Val Ala Arg Ala Met Gly Gln Ser Glu Lys                 170 175 180 gga caa gag ctc aat gag gaa aca gat gct ctg atc caa gct gcg cgt 691 Gly Gln Glu Leu Asn Glu Glu Thr Asp Ala Leu Ile Gln Ala Ala Arg             185 190 195 gat gaa aat cct tct ttt gac ggt aaa aca gga acc gtc atc ttg cca 739 Asp Glu Asn Pro Ser Phe Asp Gly Lys Thr Gly Thr Val Ile Leu Pro         200 205 210 tac cag ggt aaa tac ggt gcc tac ctg cca ggc gat gca cgg gga caa 787 Tyr Gln Gly Lys Tyr Gly Ala Tyr Leu Pro Gly Asp Ala Arg Gly Gln     215 220 225 ttc ctc gat tca ctt ggc att tcg ctg ccg gaa gca gtt ctt tcg cga 835 Phe Leu Asp Ser Leu Gly Ile Ser Leu Pro Glu Ala Val Leu Ser Arg 230 235 240 245 gac acc ggc gac agc ttc ttt gtc gat gtc ccc gct gaa agc gtc aaa 883 Asp Thr Gly Asp Ser Phe Phe Val Asp Val Pro Ala Glu Ser Val Lys                 250 255 260 gac gta gac ggt gat gtt ctc ctc gtg ctt tcc aac gac gaa aat ctg 931 Asp Val Asp Gly Asp Val Leu Leu Val Leu Ser Asn Asp Glu Asn Leu             265 270 275 gat atc aca gca gag aat cca ctg ttt gaa aca ctc aac gtt gtg caa 979 Asp Ile Thr Ala Glu Asn Pro Leu Phe Glu Thr Leu Asn Val Val Gln         280 285 290 aaa gac gca gta att gtg gca aca acc gaa gaa cgc ggg gcg att acc 1027 Lys Asp Ala Val Ile Val Ala Thr Thr Glu Glu Arg Gly Ala Ile Thr     295 300 305 tac aac tca gtg ctg tct gtt cct ttt gcg ttg gaa cat ctc gca cca 1075 Tyr Asn Ser Val Leu Ser Val Pro Phe Ala Leu Glu His Leu Ala Pro 310 315 320 325 cgt att gct gag gct ttg aag taaaactcaa ctactcgagc aca 1119 Arg Ile Ala Glu Ala Leu Lys                 330 <210> 598 <211> 332 <212> PRT <213> Corynebacterium glutamicum <400> 598 Val Gln Ser Arg Leu Ser Lys Ile Leu Arg Ser Ser Val Val Gly Val   1 5 10 15 Ala Val Leu Ala Leu Leu Ala Gly Cys Ser Asn Asn Ala Asp Asp Thr              20 25 30 Asp Ala Asp Ser Thr Ser Thr Gly Asn Ser Ala Phe Pro Val Ser Ile          35 40 45 Glu His Glu Phe Gly Thr Thr Thr Ile Asp Asp Val Pro Glu Arg Val      50 55 60 Val Thr Leu Gly Val Thr Asp Ala Asp Ile Val Leu Ala Leu Gly Thr  65 70 75 80 Val Pro Val Gly Asn Thr Gly Tyr Lys Phe Phe Glu Asn Gly Leu Gly                  85 90 95 Pro Trp Thr Asp Glu Leu Val Glu Gly Lys Glu Leu Thr Leu Leu Asp             100 105 110 Ser Asp Ser Thr Pro Asp Leu Glu Gln Val Ala Ala Leu Glu Pro Asp         115 120 125 Leu Ile Ile Gly Val Ser Ala Gly Phe Asp Asp Val Val Tyr Glu Gln     130 135 140 Leu Ser Asp Ile Ala Pro Val Val Ala Arg Pro Ala Gly Thr Ala Ala 145 150 155 160 Tyr Ala Val Ala Arg Glu Glu Ala Thr Asn Leu Val Ala Arg Ala Met                 165 170 175 Gly Gln Ser Glu Lys Gly Gln Glu Leu Asn Glu Glu Thr Asp Ala Leu             180 185 190 Ile Gln Ala Ala Arg Asp Glu Asn Pro Ser Phe Asp Gly Lys Thr Gly         195 200 205 Thr Val Ile Leu Pro Tyr Gln Gly Lys Tyr Gly Ala Tyr Leu Pro Gly     210 215 220 Asp Ala Arg Gly Gln Phe Leu Asp Ser Leu Gly Ile Ser Leu Pro Glu 225 230 235 240 Ala Val Leu Ser Arg Asp Thr Gly Asp Ser Phe Phe Val Asp Val Pro                 245 250 255 Ala Glu Ser Val Lys Asp Val Asp Gly Asp Val Leu Leu Val Leu Ser             260 265 270 Asn Asp Glu Asn Leu Asp Ile Thr Ala Glu Asn Pro Leu Phe Glu Thr         275 280 285 Leu Asn Val Val Gln Lys Asp Ala Val Ile Val Ala Thr Thr Glu Glu     290 295 300 Arg Gly Ala Ile Thr Tyr Asn Ser Val Leu Ser Val Pro Phe Ala Leu 305 310 315 320 Glu His Leu Ala Pro Arg Ile Ala Glu Ala Leu Lys                 325 330 <210> 599 <211> 1395 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (1372) <223> RXN01936 <400> 599 gcgcggtgac accacagccg ttgtcagcgg cgcttggtct gtggaggatc gccgaggtta 60 ctaacaaata ggcccaacaa agaggtctaa gctctacctg gtg agt ttc cga gat 115                                             Val Ser Phe Arg Asp                                               1 5 att ttc gct gac acc aga ccg ctg aaa gaa ccg gcc ttc aaa cgc ctc 163 Ile Phe Ala Asp Thr Arg Pro Leu Lys Glu Pro Ala Phe Lys Arg Leu                  10 15 20 tgg ctt ggc aat gtt gcc acc gtc att ggt gcc caa tta act gtt gtt 211 Trp Leu Gly Asn Val Ala Thr Val Ile Gly Ala Gln Leu Thr Val Val              25 30 35 gcc gtt ccg gtg cag att tac caa atg act ggg tcc tcc ggc tat gtg 259 Ala Val Pro Val Gln Ile Tyr Gln Met Thr Gly Ser Ser Gly Tyr Val          40 45 50 ggc ttg acc ggg ctt ttt ggc ctt att cct ttg gtt att ttt ggc ctt 307 Gly Leu Thr Gly Leu Phe Gly Leu Ile Pro Leu Val Ile Phe Gly Leu      55 60 65 tat ggt gga tcc att gcg gat gct ttt gat aaa cgc atc gtg ctg atc 355 Tyr Gly Gly Ser Ile Ala Asp Ala Phe Asp Lys Arg Ile Val Leu Ile  70 75 80 85 tgc acc acg atc ggc atg tgt gtc acc act gcc ggt ttt tgg gtg ctg 403 Cys Thr Thr Ile Gly Met Cys Val Thr Thr Ala Gly Phe Trp Val Leu                  90 95 100 acc att tta ggc aat gag aat att tgg ctc ctg tta ata aac ttt tct 451 Thr Ile Leu Gly Asn Glu Asn Ile Trp Leu Leu Leu Ile Asn Phe Ser             105 110 115 tta cag cag gca ttt ttc gcg gtg aat caa ccc acc cga acg gcg atc 499 Leu Gln Gln Ala Phe Phe Ala Val Asn Gln Pro Thr Arg Thr Ala Ile         120 125 130 ctt cga agt att ttg ccg att gat caa tta gcg tcg gca aca tca ctg 547 Leu Arg Ser Ile Leu Pro Ile Asp Gln Leu Ala Ser Ala Thr Ser Leu     135 140 145 aat atg ctg ctc atg cag acc ggc gca atc gtt ggc ccg ctg atc gca 595 Asn Met Leu Leu Met Gln Thr Gly Ala Ile Val Gly Pro Leu Ile Ala 150 155 160 165 ggt gcg ttg att ccg ctg atc ggt ttc ggg tgg ctg tat ttc ctt gat 643 Gly Ala Leu Ile Pro Leu Ile Gly Phe Gly Trp Leu Tyr Phe Leu Asp                 170 175 180 gtt gtc tcc atc atc ccc aca ctg tgg gct gta tgg tca ctg cct tcg 691 Val Val Ser Ile Ile Pro Thr Leu Trp Ala Val Trp Ser Leu Pro Ser             185 190 195 atc aag cca tcc ggc aag gtg atg aag gct ggt ttc gcc agt gtg gtg 739 Ile Lys Pro Ser Gly Lys Val Met Lys Ala Gly Phe Ala Ser Val Val         200 205 210 gat ggc ctg aag tat ttg gct ggc caa ccc gtg ttg ttg atg gtg atg 787 Asp Gly Leu Lys Tyr Leu Ala Gly Gln Pro Val Leu Leu Met Val Met     215 220 225 gtg ctg gat ctt atc gcc atg att ttc ggc atg cca cgt gcg ctt tac 835 Val Leu Asp Leu Ile Ala Met Ile Phe Gly Met Pro Arg Ala Leu Tyr 230 235 240 245 ccc gag atc gca gaa gtg aac ttc ggt ggg ggt gac gcc ggt gca acg 883 Pro Glu Ile Ala Glu Val Asn Phe Gly Gly Gly Asp Ala Gly Ala Thr                 250 255 260 atg ctg gcg ttc atg tac tca tcc atg gct gtt ggc gca gtt ctt ggc 931 Met Leu Ala Phe Met Tyr Ser Ser Met Ala Val Gly Ala Val Leu Gly             265 270 275 ggc gtg ctg tct ggt tgg gtg gcc cgg att agc cgc cag ggt gtt gca 979 Gly Val Leu Ser Gly Trp Val Ala Arg Ile Ser Arg Gln Gly Val Ala         280 285 290 gtt tat tgg tgc atc atc gcc tgg ggc gca gcc gtt gct ttg ggt ggt 1027 Val Tyr Trp Cys Ile Ile Ala Trp Gly Ala Ala Val Ala Leu Gly Gly     295 300 305 gtg gca att gtt gtc agc ccc ggc gcg gtg act gcg tgg gcg tgg atg 1075 Val Ala Ile Val Val Ser Pro Gly Ala Val Thr Ala Trp Ala Trp Met 310 315 320 325 ttc atc atc atg atg gtc att ggt ggc atg gct gac atg ttc agc tcg 1123 Phe Ile Ile Met Met Val Ile Gly Gly Met Ala Asp Met Phe Ser Ser                 330 335 340 gca gtt cga aac gct att ttg cag cag tct gct gcg gaa cat gtg cag 1171 Ala Val Arg Asn Ala Ile Leu Gln Gln Ser Ala Ala Glu His Val Gln             345 350 355 ggc cga atc caa ggt gtg tgg atc atc gtc gtg gtg ggt gga cct cgt 1219 Gly Arg Ile Gln Gly Val Trp Ile Ile Val Val Val Gly Gly Pro Arg         360 365 370 tta gct gac gtc ctt cac ggt tgg gcc gct gag ccc ctc ggc gca ggt 1267 Leu Ala Asp Val Leu His Gly Trp Ala Ala Glu Pro Leu Gly Ala Gly     375 380 385 tgg acg gta tta tgg ggc gga gta gcg gtg gtt gta ctc act gca att 1315 Trp Thr Val Leu Trp Gly Gly Val Ala Val Val Val Leu Thr Ala Ile 390 395 400 405 tgt atg gtg gcg gtg cct aaa ttc tgg aaa tac gag aaa cca aaa att 1363 Cys Met Val Ala Val Pro Lys Phe Trp Lys Tyr Glu Lys Pro Lys Ile                 410 415 420 acc ggc atc taaatactta tccatgccca ttt 1395 Thr Gly Ile <210> 600 <211> 424 <212> PRT <213> Corynebacterium glutamicum <400> 600 Val Ser Phe Arg Asp Ile Phe Ala Asp Thr Arg Pro Leu Lys Glu Pro   1 5 10 15 Ala Phe Lys Arg Leu Trp Leu Gly Asn Val Ala Thr Val Ile Gly Ala              20 25 30 Gln Leu Thr Val Val Ala Val Pro Val Gln Ile Tyr Gln Met Thr Gly          35 40 45 Ser Ser Gly Tyr Val Gly Leu Thr Gly Leu Phe Gly Leu Ile Pro Leu      50 55 60 Val Ile Phe Gly Leu Tyr Gly Gly Ser Ile Ala Asp Ala Phe Asp Lys  65 70 75 80 Arg Ile Val Leu Ile Cys Thr Thr Ile Gly Met Cys Val Thr Thr Ala                  85 90 95 Gly Phe Trp Val Leu Thr Ile Leu Gly Asn Glu Asn Ile Trp Leu Leu             100 105 110 Leu Ile Asn Phe Ser Leu Gln Gln Ala Phe Phe Ala Val Asn Gln Pro         115 120 125 Thr Arg Thr Ala Ile Leu Arg Ser Ile Leu Pro Ile Asp Gln Leu Ala     130 135 140 Ser Ala Thr Ser Leu Asn Met Leu Leu Met Gln Thr Gly Ala Ile Val 145 150 155 160 Gly Pro Leu Ile Ala Gly Ala Leu Ile Pro Leu Ile Gly Phe Gly Trp                 165 170 175 Leu Tyr Phe Leu Asp Val Val Ser Ile Pro Thr Leu Trp Ala Val             180 185 190 Trp Ser Leu Pro Ser Ile Lys Pro Ser Gly Lys Val Met Lys Ala Gly         195 200 205 Phe Ala Ser Val Val Asp Gly Leu Lys Tyr Leu Ala Gly Gln Pro Val     210 215 220 Leu Leu Met Val Met Val Leu Asp Leu Ile Ala Met Ile Phe Gly Met 225 230 235 240 Pro Arg Ala Leu Tyr Pro Glu Ile Ala Glu Val Asn Phe Gly Gly Gly                 245 250 255 Asp Ala Gly Ala Thr Met Leu Ala Phe Met Tyr Ser Ser Met Ala Val             260 265 270 Gly Ala Val Leu Gly Gly Val Leu Ser Gly Trp Val Ala Arg Ile Ser         275 280 285 Arg Gln Gly Val Ala Val Tyr Trp Cys Ile Ile Ala Trp Gly Ala Ala     290 295 300 Val Ala Leu Gly Gly Val Ala Ile Val Val Ser Pro Gly Ala Val Thr 305 310 315 320 Ala Trp Ala Trp Met Phe Ile Ile Met Met Val Ile Gly Gly Met Ala                 325 330 335 Asp Met Phe Ser Ser Ala Val Arg Asn Ala Ile Leu Gln Gln Ser Ala             340 345 350 Ala Glu His Val Gln Gly Arg Ile Gln Gly Val Trp Ile Ile Val Val         355 360 365 Val Gly Gly Pro Arg Leu Ala Asp Val Leu His Gly Trp Ala Ala Glu     370 375 380 Pro Leu Gly Ala Gly Trp Thr Val Leu Trp Gly Gly Val Ala Val Val 385 390 395 400 Val Leu Thr Ala Ile Cys Met Val Ala Val Pro Lys Phe Trp Lys Tyr                 405 410 415 Glu Lys Pro Lys Ile Thr Gly Ile             420 <210> 601 <211> 1461 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (1438) <223> RXN01995 <400> 601 ccgacgcaaa ggcatgcgcc tgcgtgtctc gagtagtctc ctccccttcc tcgtccccaa 60 cctcgaccat tacggtcgcc ctctcctaaa ggagcctggc atg gat atc cgc caa 115                                             Met Asp Ile Arg Gln                                               1 5 aca att aac gac aca gca atg tcg aga tat cag tgg ttc att gta ttt 163 Thr Ile Asn Asp Thr Ala Met Ser Arg Tyr Gln Trp Phe Ile Val Phe                  10 15 20 atc gca gtg ctg ctc aac gca ctg gac ggc ttt gat gtc ctc gcc atg 211 Ile Ala Val Leu Leu Asn Ala Leu Asp Gly Phe Asp Val Leu Ala Met              25 30 35 tct ttt act gcg aat gca gtg acc gaa gaa ttt gga ctg agt ggc agc 259 Ser Phe Thr Ala Asn Ala Val Thr Glu Glu Phe Gly Leu Ser Gly Ser          40 45 50 cag ctt ggt gtg ctg ctg agt tcc gcg ctg ttc ggc atg acc gct gga 307 Gln Leu Gly Val Leu Leu Ser Ser Ala Leu Phe Gly Met Thr Ala Gly      55 60 65 tct ttg ctg ttc ggt ccg atc ggt gac cgt ttc ggc cgt aag aat gcc 355 Ser Leu Leu Phe Gly Pro Ile Gly Asp Arg Phe Gly Arg Lys Asn Ala  70 75 80 85 ctg atg atc gcg ctg ctg ttc aac gtg gtg gga ttg gta ttg tcc gcc 403 Leu Met Ile Ala Leu Leu Phe Asn Val Val Gly Leu Val Leu Ser Ala                  90 95 100 acc gcg cag tcc gca ggc cag ttg ggc gtg tgg cgt ttg atc act ggt 451 Thr Ala Gln Ser Ala Gly Gln Leu Gly Val Trp Arg Leu Ile Thr Gly             105 110 115 atc ggc atc ggc gga atc ctc gcc tgc atc aca gtg gtg atc agt gag 499 Ile Gly Ile Gly Gly Ile Leu Ala Cys Ile Thr Val Val Ile Ser Glu         120 125 130 ttc tcc aac aac aaa aac cgc ggc atg gcc atg tcc atc tac gct gct 547 Phe Ser Asn Asn Lys Asn Arg Gly Met Ala Met Ser Ile Tyr Ala Ala     135 140 145 ggt tac ggc atc ggc gcg tcc ttg ggc ggt ttc ggc gca gcg cag ctc 595 Gly Tyr Gly Ile Gly Ala Ser Leu Gly Gly Phe Gly Ala Ala Gln Leu 150 155 160 165 atc cca aca ttt gga tgg cgc tcc gtg ttc gca gcc ggt gcg atc gca 643 Ile Pro Thr Phe Gly Trp Arg Ser Val Phe Ala Ala Gly Ala Ile Ala                 170 175 180 act ggt atc gcc acc atc gct act ttc ttc ttc ctg cca gaa tcc gtt 691 Thr Gly Ile Ala Thr Ile Ala Thr Phe Phe Phe Leu Pro Glu Ser Val             185 190 195 gat tgg ctg agc act cgc cgc cct gcg ggc gct cgc gac aag atc aat 739 Asp Trp Leu Ser Thr Arg Arg Pro Ala Gly Ala Arg Asp Lys Ile Asn         200 205 210 tac att gcg cgc cgc ctg ggc aaa gtc ggt acc ttt gag ctt cca ggc 787 Tyr Ile Ala Arg Arg Leu Gly Lys Val Gly Thr Phe Glu Leu Pro Gly     215 220 225 gaa caa agc ttg tcg acg aaa aaa gcc ggt ctc caa tcg tat gca gtg 835 Glu Gln Ser Leu Ser Thr Lys Lys Ala Gly Leu Gln Ser Tyr Ala Val 230 235 240 245 ctc gtt aac aaa gag aac cgt gga acc agc atc aag ctg tgg gtt gcg 883 Leu Val Asn Lys Glu Asn Arg Gly Thr Ser Ile Lys Leu Trp Val Ala                 250 255 260 ttc ggc atc gtg atg ttc ggc ttc tac ttc gcc aac act tgg acc ccg 931 Phe Gly Ile Val Met Phe Gly Phe Tyr Phe Ala Asn Thr Trp Thr Pro             265 270 275 aag ctg ctc gtg gaa acc gga atg tca gaa cag cag ggc atc atc ggt 979 Lys Leu Leu Val Glu Thr Gly Met Ser Glu Gln Gln Gly Ile Ile Gly         280 285 290 ggt ttg atg ttg tcc atg ggt gga gca ttc ggc tcc ctg ctc tac ggt 1027 Gly Leu Met Leu Ser Met Gly Gly Ala Phe Gly Ser Leu Leu Tyr Gly     295 300 305 ttc ctc acc acc aag ttc agc tcc cga aac aca ctg atg acc ttc atg 1075 Phe Leu Thr Thr Lys Phe Ser Ser Arg Asn Thr Leu Met Thr Phe Met 310 315 320 325 gtg ctg tcc ggc ctg acg ctg atc ctg ttc att tcc tcc acc tct gtt 1123 Val Leu Ser Gly Leu Thr Leu Ile Leu Phe Ile Ser Ser Thr Ser Val                 330 335 340 cca tcc atc gcg ttt gcc agc ggc gtt gtc gtg ggc atg ctg atc aat 1171 Pro Ser Ile Ala Phe Ala Ser Gly Val Val Val Gly Met Leu Ile Asn             345 350 355 ggt tgt gtg gct ggt ctg tac acc ctg tcc cca cag ctg tac tcc gct 1219 Gly Cys Val Ala Gly Leu Tyr Thr Leu Ser Pro Gln Leu Tyr Ser Ala         360 365 370 gaa gta cgc acc act ggt gtg ggc gct gcg att ggt atg ggt cgt gtc 1267 Glu Val Arg Thr Thr Gly Val Gly Ala Ala Ile Gly Met Gly Arg Val     375 380 385 ggt gcg att tcc gcg cca ctg ctg gtg ggt ggc ctg ctg gat tct ggc 1315 Gly Ala Ile Ser Ala Pro Leu Leu Val Gly Gly Leu Leu Asp Ser Gly 390 395 400 405 tgg tcc cca acg cag ctg tat gtt ggt gtg gca gtg att gtt att gcc 1363 Trp Ser Pro Thr Gln Leu Tyr Val Gly Val Ala Val Ile Val Ile Ala                 410 415 420 ggt gca acc gca ttg att ggg atg cgc act cag gcg gta gcc gtc gaa 1411 Gly Ala Thr Ala Leu Ile Gly Met Arg Thr Gln Ala Val Ala Val Glu             425 430 435 aag cag cct gaa gcc cta gcg acc aaa tagggccgcg attcctagca 1458 Lys Gln Pro Glu Ala Leu Ala Thr Lys         440 445 tgc 1461 <210> 602 <211> 446 <212> PRT <213> Corynebacterium glutamicum <400> 602 Met Asp Ile Arg Gln Thr Ile Asn Asp Thr Ala Met Ser Arg Tyr Gln   1 5 10 15 Trp Phe Ile Val Phe Ile Ala Val Leu Leu Asn Ala Leu Asp Gly Phe              20 25 30 Asp Val Leu Ala Met Ser Phe Thr Ala Asn Ala Val Thr Glu Glu Phe          35 40 45 Gly Leu Ser Gly Ser Gln Leu Gly Val Leu Leu Ser Ser Ala Leu Phe      50 55 60 Gly Met Thr Ala Gly Ser Leu Leu Phe Gly Pro Ile Gly Asp Arg Phe  65 70 75 80 Gly Arg Lys Asn Ala Leu Met Ile Ala Leu Leu Phe Asn Val Val Gly                  85 90 95 Leu Val Leu Ser Ala Thr Ala Gln Ser Ala Gly Gln Leu Gly Val Trp             100 105 110 Arg Leu Ile Thr Gly Ile Gly Ile Gly Gly Ile Leu Ala Cys Ile Thr         115 120 125 Val Val Ile Ser Glu Phe Ser Asn Asn Lys Asn Arg Gly Met Ala Met     130 135 140 Ser Ile Tyr Ala Ala Gly Tyr Gly Ile Gly Ala Ser Leu Gly Gly Phe 145 150 155 160 Gly Ala Ala Gln Leu Ile Pro Thr Phe Gly Trp Arg Ser Val Phe Ala                 165 170 175 Ala Gly Ala Ile Ala Thr Gly Ile Ala Thr Ile Ala Thr Phe Phe Phe             180 185 190 Leu Pro Glu Ser Val Asp Trp Leu Ser Thr Arg Arg Pro Ala Gly Ala         195 200 205 Arg Asp Lys Ile Asn Tyr Ile Ala Arg Arg Leu Gly Lys Val Gly Thr     210 215 220 Phe Glu Leu Pro Gly Glu Gln Ser Leu Ser Thr Lys Lys Ala Gly Leu 225 230 235 240 Gln Ser Tyr Ala Val Leu Val Asn Lys Glu Asn Arg Gly Thr Ser Ile                 245 250 255 Lys Leu Trp Val Ala Phe Gly Ile Val Met Phe Gly Phe Tyr Phe Ala             260 265 270 Asn Thr Trp Thr Pro Lys Leu Leu Val Glu Thr Gly Met Ser Glu Gln         275 280 285 Gln Gly Ile Ile Gly Gly Leu Met Leu Ser Met Gly Gly Ala Phe Gly     290 295 300 Ser Leu Leu Tyr Gly Phe Leu Thr Thr Lys Phe Ser Ser Arg Asn Thr 305 310 315 320 Leu Met Thr Phe Met Val Leu Ser Gly Leu Thr Leu Ile Leu Phe Ile                 325 330 335 Ser Ser Thr Ser Val Pro Ser Ile Ala Phe Ala Ser Gly Val Val Val             340 345 350 Gly Met Leu Ile Asn Gly Cys Val Ala Gly Leu Tyr Thr Leu Ser Pro         355 360 365 Gln Leu Tyr Ser Ala Glu Val Arg Thr Thr Gly Val Gly Ala Ala Ile     370 375 380 Gly Met Gly Arg Val Gly Ala Ile Ser Ala Pro Leu Leu Val Gly Gly 385 390 395 400 Leu Leu Asp Ser Gly Trp Ser Pro Thr Gln Leu Tyr Val Gly Val Ala                 405 410 415 Val Ile Val Ile Ala Gly Ala Thr Ala Leu Ile Gly Met Arg Thr Gln             420 425 430 Ala Val Ala Val Glu Lys Gln Pro Glu Ala Leu Ala Thr Lys         435 440 445 <210> 603 <211> 813 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (790) <223> RXN00661 <400> 603 cggatgcaag agaaccgtgg tttcgctgat ttttggcgaa cccggaatta aggccccgag 60 gattacatgc ttttaaatcc tttgaaaagg ggacaagatc atg aat cct ata acc 115                                             Met Asn Pro Ile Thr                                               1 5 gaa tta tta gac gca aca cta tgg atc ggc gga gtt ccg att ctg tgg 163 Glu Leu Leu Asp Ala Thr Leu Trp Ile Gly Gly Val Pro Ile Leu Trp                  10 15 20 cgc gaa atc atc ggc aac gtt ttc gga tta ttt agc gcg tgg gca gga 211 Arg Glu Ile Ile Gly Asn Val Phe Gly Leu Phe Ser Ala Trp Ala Gly              25 30 35 atg cga cgc atc gtg tgg gca tgg ccc atc ggc atc ata ggc aac gcg 259 Met Arg Arg Ile Val Trp Ala Trp Pro Ile Gly Ile Ile Gly Asn Ala          40 45 50 ctg ctg ttc aca gta ttt atg ggc ggc ctt ttc cac act cca caa aac 307 Leu Leu Phe Thr Val Phe Met Gly Gly Leu Phe His Thr Pro Gln Asn      55 60 65 ctc gat ctc tac ggc caa gcg ggt cgc cag atc atg ttc atc atc gtc 355 Leu Asp Leu Tyr Gly Gln Ala Gly Arg Gln Ile Met Phe Ile Ile Val  70 75 80 85 agt ggt tat ggc tgg tac caa tgg tcg gcc gca aaa cgt cgc gca ctc 403 Ser Gly Tyr Gly Trp Tyr Gln Trp Ser Ala Ala Lys Arg Arg Ala Leu                  90 95 100 acc cca gaa aat gca gta gca gtg gtt cct cgc tgg gca agc acc aaa 451 Thr Pro Glu Asn Ala Val Ala Val Val Pro Arg Trp Ala Ser Thr Lys             105 110 115 gaa cgc gcc ggc att gtg att gcg gcg gtt gtg gga aca ctc agc ttt 499 Glu Arg Ala Gly Ile Val Ile Ala Ala Val Val Gly Thr Leu Ser Phe         120 125 130 gcc tgg att ttc caa gca ctc ggc tcc tgg ggg cca tgg gcc gac gcg 547 Ala Trp Ile Phe Gln Ala Leu Gly Ser Trp Gly Pro Trp Ala Asp Ala     135 140 145 tgg att ttc gtc ggc tca atc ctg gct acc tac gga atg gct cgc gga 595 Trp Ile Phe Val Gly Ser Ile Leu Ala Thr Tyr Gly Met Ala Arg Gly 150 155 160 165 tgg aca gag ttc tgg ctg atc tgg atc gcc gtc gac ata gtt ggc gtt 643 Trp Thr Glu Phe Trp Leu Ile Trp Ile Ala Val Asp Ile Val Gly Val                 170 175 180 cct cta ctt ttg act gct ggc tac tac cca tcc gcg gtg ctt tac ctg 691 Pro Leu Leu Leu Thr Ala Gly Tyr Tyr Pro Ser Ala Val Leu Tyr Leu             185 190 195 gtg tac ggt gcg ttt gtc agc tgg gga ttt gtc gtg tgg ctg cgg gtg 739 Val Tyr Gly Ala Phe Val Ser Trp Gly Phe Val Val Trp Leu Arg Val         200 205 210 caa aaa gca gac aag gct cgt gcg ctg gaa gct cag gag tct gtg aca 787 Gln Lys Ala Asp Lys Ala Arg Ala Leu Glu Ala Gln Glu Ser Val Thr     215 220 225 gtc tgaaaagcgt ttactaaata gaa 813 Val 230 <210> 604 <211> 230 <212> PRT <213> Corynebacterium glutamicum <400> 604 Met Asn Pro Ile Thr Glu Leu Leu Asp Ala Thr Leu Trp Ile Gly Gly   1 5 10 15 Val Pro Ile Leu Trp Arg Glu Ile Ile Gly Asn Val Phe Gly Leu Phe              20 25 30 Ser Ala Trp Ala Gly Met Arg Arg Ile Val Trp Ala Trp Pro Ile Gly          35 40 45 Ile Ile Gly Asn Ala Leu Leu Phe Thr Val Phe Met Gly Gly Leu Phe      50 55 60 His Thr Pro Gln Asn Leu Asp Leu Tyr Gly Gln Ala Gly Arg Gln Ile  65 70 75 80 Met Phe Ile Ile Val Ser Gly Tyr Gly Trp Tyr Gln Trp Ser Ala Ala                  85 90 95 Lys Arg Arg Ala Leu Thr Pro Glu Asn Ala Val Ala Val Val Pro Arg             100 105 110 Trp Ala Ser Thr Lys Glu Arg Ala Gly Ile Val Ile Ala Ala Val Val         115 120 125 Gly Thr Leu Ser Phe Ala Trp Ile Phe Gln Ala Leu Gly Ser Trp Gly     130 135 140 Pro Trp Ala Asp Ala Trp Ile Phe Val Gly Ser Ile Leu Ala Thr Tyr 145 150 155 160 Gly Met Ala Arg Gly Trp Thr Glu Phe Trp Leu Ile Trp Ile Ala Val                 165 170 175 Asp Ile Val Gly Val Pro Leu Leu Leu Thr Ala Gly Tyr Tyr Pro Ser             180 185 190 Ala Val Leu Tyr Leu Val Tyr Gly Ala Phe Val Ser Trp Gly Phe Val         195 200 205 Val Trp Leu Arg Val Gln Lys Ala Asp Lys Ala Arg Ala Leu Glu Ala     210 215 220 Gln Glu Ser Val Thr Val 225 230 <210> 605 <211> 1332 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) .. (1309) <223> RXN02566 <400> 605 gactccggat gatcaagcag cgaaaccttt gtcaagaaca tagctcccca ccctagacaa 60 aagcccaaat aaatctgctc aataacctaa cctaaagtcc atg cac gcc tcg tcg 115                                             Met His Ala Ser Ser                                               1 5 ccc caa cct cac cct cag cgc acc cgt gtt ctc agc ggc ctg att ttc 163 Pro Gln Pro His Pro Gln Arg Thr Arg Val Leu Ser Gly Leu Ile Phe                  10 15 20 gcc caa atc atg gtt ggt gca tcc aat ggc gtg acg cta tcg atg gga 211 Ala Gln Ile Met Val Gly Ala Ser Asn Gly Val Thr Leu Ser Met Gly              25 30 35 agt ttg ctg gca gca cac ttg gcg gga gct tcg tgg gga gga tca gcc 259 Ser Leu Leu Ala Ala His Leu Ala Gly Ala Ser Trp Gly Gly Ser Ala          40 45 50 gcc aca ttg acc acg atc ggc gca gct atc ttt tcg att ccc ctt gcc 307 Ala Thr Leu Thr Thr Ile Gly Ala Ala Ile Phe Ser Ile Pro Leu Ala      55 60 65 cgc atg gtc tcc aca tac gat cgc cga act tca ctc agc acg ggc atg 355 Arg Met Val Ser Thr Tyr Asp Arg Arg Thr Ser Leu Ser Thr Gly Met  70 75 80 85 ttg ctt ggt tgc gtg ggc gca cta ctg gcg atc ctc ggc gca caa ttc 403 Leu Leu Gly Cys Val Gly Ala Leu Leu Ala Ile Leu Gly Ala Gln Phe                  90 95 100 ggc ttg ttt cca gta gta ctt ttg gca ttt ttg ttc ctc gga tcc atg 451 Gly Leu Phe Pro Val Val Leu Leu Ala Phe Leu Phe Leu Gly Ser Met             105 110 115 tcg gcg gtt aac ctc caa gca cgt ttc gcc gca acc gac gtg gcc agt 499 Ser Ala Val Asn Leu Gln Ala Arg Phe Ala Ala Thr Asp Val Ala Ser         120 125 130 gaa gaa acc cgc ggc cgc gac ctc tcg atc gtt gtg tgg tcc acc acc 547 Glu Glu Thr Arg Gly Arg Asp Leu Ser Ile Val Val Trp Ser Thr Thr     135 140 145 atc ggc gca atc gcc gga cca aat tta ttt gaa cca agc gcc cga ttc 595 Ile Gly Ala Ile Ala Gly Pro Asn Leu Phe Glu Pro Ser Ala Arg Phe 150 155 160 165 agc gaa acc ctg ggc ctc gaa caa cat gcc ggc gca tac ctg ctg tgt 643 Ser Glu Thr Leu Gly Leu Glu Gln His Ala Gly Ala Tyr Leu Leu Cys                 170 175 180 tta ttt ggc cag ctc atc gcc atc gca gtc tgg cga ttc acc ctc ccc 691 Leu Phe Gly Gln Leu Ile Ala Ile Ala Val Trp Arg Phe Thr Leu Pro             185 190 195 aaa ggc ctc aaa ccc gaa gcc acc cca aat gca cca aca gaa aag aag 739 Lys Gly Leu Lys Pro Glu Ala Thr Pro Asn Ala Pro Thr Glu Lys Lys         200 205 210 cgc ctc acc ccg aaa gcc ctc caa gcc atc aca tcg gtt gca acc gca 787 Arg Leu Thr Pro Lys Ala Leu Gln Ala Ile Thr Ser Val Ala Thr Ala     215 220 225 cac ttc tcc atg gtc ggt ctc atg tcc atg gcc gcc atc cac atg caa 835 His Phe Ser Met Val Gly Leu Met Ser Met Ala Ala Ile His Met Gln 230 235 240 245 ggc cac ggc gcc agc ctc acc atc atc ggc ttc acc atc agt ttg cac 883 Gly His Gly Ala Ser Leu Thr Ile Ile Gly Phe Thr Ile Ser Leu His                 250 255 260 gtc gcc gga atg tac gca ctc tca cca gtg ttc ggc ctg ctc aca gac 931 Val Ala Gly Met Tyr Ala Leu Ser Pro Val Phe Gly Leu Leu Thr Asp             265 270 275 aaa ctc ggc cgc aat gtc acc atc tat tcc ggc ttc gcc atg ctc gcc 979 Lys Leu Gly Arg Asn Val Thr Ile Tyr Ser Gly Phe Ala Met Leu Ala         280 285 290 aca tcc gca gca ttt ctt atc att tgg ccc gaa cca cag tgg gcc atg 1027 Thr Ser Ala Ala Phe Leu Ile Ile Trp Pro Glu Pro Gln Trp Ala Met     295 300 305 atc aca tcc atg atc ctg ctt ggg ctc ggc tgg aac tct gcc ctc gtc 1075 Ile Thr Ser Met Ile Leu Leu Gly Leu Gly Trp Asn Ser Ala Leu Val 310 315 320 325 ggt tct tca aca ttg ctt gtc gac gcc acc ccc atc cac cac cgc acc 1123 Gly Ser Ser Thr Leu Leu Val Asp Ala Thr Pro Ile His His Arg Thr                 330 335 340 tac gcc cag ggg cgc agc gac cta acg atg aat ctt gcg gga gct tca 1171 Tyr Ala Gln Gly Arg Ser Asp Leu Thr Met Asn Leu Ala Gly Ala Ser             345 350 355 ggc ggg ttg atc gcc gga ccg tta att gcc atg ggc gga atg ccc ttg 1219 Gly Gly Leu Ile Ala Gly Pro Leu Ile Ala Met Gly Gly Met Pro Leu         360 365 370 ttg gca ggc gtc gtt ctt gca gtt gtg gcg ctt caa acg gtg ctt agt 1267 Leu Ala Gly Val Val Leu Ala Val Val Ala Leu Gln Thr Val Leu Ser     375 380 385 ttc aga acc cgt tca att gaa aag act cct gct tca tgt ttt 1309 Phe Arg Thr Arg Ser Ile Glu Lys Thr Pro Ala Ser Cys Phe 390 395 400 tagcctagga attcacgcac gac 1332 <210> 606 <211> 403 <212> PRT <213> Corynebacterium glutamicum <400> 606 Met His Ala Ser Ser Pro Gln Pro His Pro Gln Arg Thr Arg Val Leu   1 5 10 15 Ser Gly Leu Ile Phe Ala Gln Ile Met Val Gly Ala Ser Asn Gly Val              20 25 30 Thr Leu Ser Met Gly Ser Leu Leu Ala Ala His Leu Ala Gly Ala Ser          35 40 45 Trp Gly Gly Ser Ala Ala Thr Leu Thr Thr Ile Gly Ala Ala Ile Phe      50 55 60 Ser Ile Pro Leu Ala Arg Met Val Ser Thr Tyr Asp Arg Arg Thr Ser  65 70 75 80 Leu Ser Thr Gly Met Leu Leu Gly Cys Val Gly Ala Leu Leu Ala Ile                  85 90 95 Leu Gly Ala Gln Phe Gly Leu Phe Pro Val Val Leu Lela Ala Phe Leu             100 105 110 Phe Leu Gly Ser Met Ser Ala Val Asn Leu Gln Ala Arg Phe Ala Ala         115 120 125 Thr Asp Val Ala Ser Glu Glu Thr Arg Gly Arg Asp Leu Ser Ile Val     130 135 140 Val Trp Ser Thr Thr Ile Gly Ala Ile Ala Gly Pro Asn Leu Phe Glu 145 150 155 160 Pro Ser Ala Arg Phe Ser Glu Thr Leu Gly Leu Glu Gln His Ala Gly                 165 170 175 Ala Tyr Leu Leu Cys Leu Phe Gly Gln Leu Ile Ala Ile Ala Val Trp             180 185 190 Arg Phe Thr Leu Pro Lys Gly Leu Lys Pro Glu Ala Thr Pro Asn Ala         195 200 205 Pro Thr Glu Lys Lys Arg Leu Thr Pro Lys Ala Leu Gln Ala Ile Thr     210 215 220 Ser Val Ala Thr Ala His Phe Ser Met Val Gly Leu Met Ser Met Ala 225 230 235 240 Ala Ile His Met Gln Gly His Gly Ala Ser Leu Thr Ile Ile Gly Phe                 245 250 255 Thr Ile Ser Leu His Val Ala Gly Met Tyr Ala Leu Ser Pro Val Phe             260 265 270 Gly Leu Leu Thr Asp Lys Leu Gly Arg Asn Val Thr Ile Tyr Ser Gly         275 280 285 Phe Ala Met Leu Ala Thr Ser Ala Ala Phe Leu Ile Irp Trp Pro Glu     290 295 300 Pro Gln Trp Ala Met Ile Thr Ser Met Ile Leu Leu Gly Leu Gly Trp 305 310 315 320 Asn Ser Ala Leu Val Gly Ser Ser Thr Leu Leu Val Asp Ala Thr Pro                 325 330 335 Ile His His Arg Thr Tyr Ala Gln Gly Arg Ser Asp Leu Thr Met Asn             340 345 350 Leu Ala Gly Ala Ser Gly Gly Leu Ile Ala Gly Pro Leu Ile Ala Met         355 360 365 Gly Gly Met Pro Leu Leu Ala Gly Val Val Leu Ala Val Val Ala Leu     370 375 380 Gln Thr Val Leu Ser Phe Arg Thr Arg Ser Ile Glu Lys Thr Pro Ala 385 390 395 400 Ser cys phe <210> 607 <211> 760 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (760) <223> FRXA02561 <400> 607 atctgctcaa taacctaacc taaagtccat gcacgcctcg tcgccccaac ctcaccctca 60 gcgcacccgt gttctcagcg gcctgatttt cgcccaaatc atg gtt ggt gca tcc 115                                             Met Val Gly Ala Ser                                               1 5 aat ggc gtg acg cta tcg atg gga agt ttg ctg gca gca cac ttg gcg 163 Asn Gly Val Thr Leu Ser Met Gly Ser Leu Leu Ala Ala His Leu Ala                  10 15 20 gga gct tcg tgg gga gga tca gcc gcc aca ttg acc acg atc ggc gca 211 Gly Ala Ser Trp Gly Gly Ser Ala Ala Thr Leu Thr Thr Ile Gly Ala              25 30 35 gct atc ttt tcg att ccc ctt gcc cgc atg gtc tcc aca tac gat cgc 259 Ala Ile Phe Ser Ile Pro Leu Ala Arg Met Val Ser Thr Tyr Asp Arg          40 45 50 cga act tca ctc agc acg ggc atg ttg ctt ggt tgc gtg ggc gca cta 307 Arg Thr Ser Leu Ser Thr Gly Met Leu Leu Gly Cys Val Gly Ala Leu      55 60 65 ctg gcg atc ctc ggc gca caa ttc ggc ttg ttt cca gta gta ctt ttg 355 Leu Ala Ile Leu Gly Ala Gln Phe Gly Leu Phe Pro Val Val Leu Leu  70 75 80 85 gca ttt ttg ttc ctc gga tcc atg tcg gcg gtt aac ctc caa gca cgt 403 Ala Phe Leu Phe Leu Gly Ser Met Ser Ala Val Asn Leu Gln Ala Arg                  90 95 100 ttc gcc gca acc gac gtg gcc agt gaa gaa acc cgc ggc cgc gac ctc 451 Phe Ala Ala Thr Asp Val Ala Ser Glu Glu Thr Arg Gly Arg Asp Leu             105 110 115 tcg atc gtt gtg tgg tcc acc acc atc ggc gca atc gcc gga cca aat 499 Ser Ile Val Val Trp Ser Thr Thr Ile Gly Ala Ile Ala Gly Pro Asn         120 125 130 tta ttt gaa cca agc gcc cga ttc agc gaa acc ctg ggc ctc gaa caa 547 Leu Phe Glu Pro Ser Ala Arg Phe Ser Glu Thr Leu Gly Leu Glu Gln     135 140 145 cat gcc ggc gca tac ctg ctg tgt tta ttt ggc cag ctc atc gcc atc 595 His Ala Gly Ala Tyr Leu Leu Cys Leu Phe Gly Gln Leu Ile Ala Ile 150 155 160 165 gca gtc tgg cga ttc acc ctc ccc aaa ggc ctc aaa ccc gaa gcc acc 643 Ala Val Trp Arg Phe Thr Leu Pro Lys Gly Leu Lys Pro Glu Ala Thr                 170 175 180 cca aat gca cca aca gaa aag aag cgc ctc acc ccg aaa gcc ctc caa 691 Pro Asn Ala Pro Thr Glu Lys Lys Arg Leu Thr Pro Lys Ala Leu Gln             185 190 195 gcc atc aca tcg gtt gca acc gca cac ttc tcc atg gtc ggt ctc atg 739 Ala Ile Thr Ser Val Ala Thr Ala His Phe Ser Met Val Gly Leu Met         200 205 210 tcc atg gcc gcc atc cac atg 760 Ser Met Ala Ala Ile His Met     215 220 <210> 608 <211> 220 <212> PRT <213> Corynebacterium glutamicum <400> 608 Met Val Gly Ala Ser Asn Gly Val Thr Leu Ser Met Gly Ser Leu Leu   1 5 10 15 Ala Ala His Leu Ala Gly Ala Ser Trp Gly Gly Ser Ala Ala Thr Leu              20 25 30 Thr Thr Ile Gly Ala Ala Ile Phe Ser Ile Pro Leu Ala Arg Met Val          35 40 45 Ser Thr Tyr Asp Arg Arg Thr Ser Leu Ser Thr Gly Met Leu Leu Gly      50 55 60 Cys Val Gly Ala Leu Leu Ala Ile Leu Gly Ala Gln Phe Gly Leu Phe  65 70 75 80 Pro Val Val Leu Leu Ala Phe Leu Phe Leu Gly Ser Met Ser Ala Val                  85 90 95 Asn Leu Gln Ala Arg Phe Ala Ala Thr Asp Val Ala Ser Glu Glu Thr             100 105 110 Arg Gly Arg Asp Leu Ser Ile Val Val Trp Ser Thr Thr Ile Gly Ala         115 120 125 Ile Ala Gly Pro Asn Leu Phe Glu Pro Ser Ala Arg Phe Ser Glu Thr     130 135 140 Leu Gly Leu Glu Gln His Ala Gly Ala Tyr Leu Leu Cys Leu Phe Gly 145 150 155 160 Gln Leu Ile Ala Ile Ala Val Trp Arg Phe Thr Leu Pro Lys Gly Leu                 165 170 175 Lys Pro Glu Ala Thr Pro Asn Ala Pro Thr Glu Lys Lys Arg Leu Thr             180 185 190 Pro Lys Ala Leu Gln Ala Ile Thr Ser Val Ala Thr Ala His Phe Ser         195 200 205 Met Val Gly Leu Met Ser Met Ala Ala Ile His Met     210 215 220 <210> 609 <211> 461 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (438) <223> FRXA02566 <400> 609 atc agt ttg cac gtc gcc gga atg tac gca ctc tca cca gtg ttc ggc 48 Ile Ser Leu His Val Ala Gly Met Tyr Ala Leu Ser Pro Val Phe Gly   1 5 10 15 ctg ctc aca gac aaa ctc ggc cgc aat gtc acc atc tat tcc ggc ttc 96 Leu Leu Thr Asp Lys Leu Gly Arg Asn Val Thr Ile Tyr Ser Gly Phe              20 25 30 gcc atg ctc gcc aca tcc gca gca ttt ctt atc att tgg ccc gaa cca 144 Ala Met Leu Ala Thr Ser Ala Ala Phe Leu Ile Ile Trp Pro Glu Pro          35 40 45 cag tgg gcc atg atc aca tcc atg atc ctg ctt ggg ctc ggc tgg aac 192 Gln Trp Ala Met Ile Thr Ser Met Ile Leu Leu Gly Leu Gly Trp Asn      50 55 60 tct gcc ctc gtc ggt tct tca aca ttg ctt gtc gac gcc acc ccc atc 240 Ser Ala Leu Val Gly Ser Ser Thr Leu Leu Val Asp Ala Thr Pro Ile  65 70 75 80 cac cac cgc acc tac gcc cag ggg cgc agc gac cta acg atg aat ctt 288 His His Arg Thr Tyr Ala Gln Gly Arg Ser Asp Leu Thr Met Asn Leu                  85 90 95 gcg gga gct tca ggc ggg ttg atc gcc gga ccg tta att gcc atg ggc 336 Ala Gly Ala Ser Gly Gly Leu Ile Ala Gly Pro Leu Ile Ala Met Gly             100 105 110 gga atg ccc ttg ttg gca ggc gtc gtt ctt gca gtt gtg gcg ctt caa 384 Gly Met Pro Leu Leu Ala Gly Val Val Leu Ala Val Val Ala Leu Gln         115 120 125 acg gtg ctt agt ttc aga acc cgt tca att gaa aag act cct gct tca 432 Thr Val Leu Ser Phe Arg Thr Arg Ser Ile Glu Lys Thr Pro Ala Ser     130 135 140 tgt ttt tagcctagga attcacgcac gac 461 Cys phe 145 <210> 610 <211> 146 <212> PRT <213> Corynebacterium glutamicum <400> 610 Ile Ser Leu His Val Ala Gly Met Tyr Ala Leu Ser Pro Val Phe Gly   1 5 10 15 Leu Leu Thr Asp Lys Leu Gly Arg Asn Val Thr Ile Tyr Ser Gly Phe              20 25 30 Ala Met Leu Ala Thr Ser Ala Ala Phe Leu Ile Ile Trp Pro Glu Pro          35 40 45 Gln Trp Ala Met Ile Thr Ser Met Ile Leu Leu Gly Leu Gly Trp Asn      50 55 60 Ser Ala Leu Val Gly Ser Ser Thr Leu Leu Val Asp Ala Thr Pro Ile  65 70 75 80 His His Arg Thr Tyr Ala Gln Gly Arg Ser Asp Leu Thr Met Asn Leu                  85 90 95 Ala Gly Ala Ser Gly Gly Leu Ile Ala Gly Pro Leu Ile Ala Met Gly             100 105 110 Gly Met Pro Leu Leu Ala Gly Val Val Leu Ala Val Val Ala Leu Gln         115 120 125 Thr Val Leu Ser Phe Arg Thr Arg Ser Ile Glu Lys Thr Pro Ala Ser     130 135 140 Cys phe 145 <210> 611 <211> 1527 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1504) <223> RXA00051 <400> 611 cagtaaaagt gcaccgacac taagaatcct tatccttcag agtaaggtga tctgcgtcaa 60 aaaatgtccg ctattcaccc gaaacgaggt cagcatctcg atg aat gcc tcc cct 115                                             Met Asn Ala Ser Pro                                               1 5 gcc cca acc cga tct ttt aaa gga ttg cgg gct cga cac att cac ttc 163 Ala Pro Thr Arg Ser Phe Lys Gly Leu Arg Ala Arg His Ile His Phe                  10 15 20 atc gcg ctg ggt tcc gcg atc ggc acc ggc ttg ttc tac ggt tcc gct 211 Ile Ala Leu Gly Ser Ala Ile Gly Thr Gly Leu Phe Tyr Gly Ser Ala              25 30 35 ggc gca atc caa gca gct ggt cca tct gta ctc ttg gtc tac ctt ctc 259 Gly Ala Ile Gln Ala Ala Gly Pro Ser Val Leu Leu Val Tyr Leu Leu          40 45 50 ggt ggc gcc gtc gtg tac ttc atg ctg cgc gca ctc ggc gag atg gct 307 Gly Gly Ala Val Val Tyr Phe Met Leu Arg Ala Leu Gly Glu Met Ala      55 60 65 gtg cat cac cca gtc cgt ggt tcc ttc gcg gtc tac acc cgc gca cac 355 Val His His Pro Val Arg Gly Ser Phe Ala Val Tyr Thr Arg Ala His  70 75 80 85 ctt ggc gga tgg gca ggc tac atc acc ggc tgg atg ttc gcg ttt gag 403 Leu Gly Gly Trp Ala Gly Tyr Ile Thr Gly Trp Met Phe Ala Phe Glu                  90 95 100 atg ctc atc gtc tgc ctg gct gac ctc aca gcc atc ggc atc tat atg 451 Met Leu Ile Val Cys Leu Ala Asp Leu Thr Ala Ile Gly Ile Tyr Met             105 110 115 aac ttc tgg ttc ccc ggc acc cca caa tgg act tgg gtg gta gcc acc 499 Asn Phe Trp Phe Pro Gly Thr Pro Gln Trp Thr Trp Val Val Ala Thr         120 125 130 ctt ctt att gtc ggt ggc gca aac ctc gca tca gtg cgt tgg ttc ggt 547 Leu Leu Ile Val Gly Gly Ala Asn Leu Ala Ser Val Arg Trp Phe Gly     135 140 145 gag ctc gag ttc atc ttc acc atc att aag gtc acc gca gtt gtc gcc 595 Glu Leu Glu Phe Ile Phe Thr Ile Ile Lys Val Thr Ala Val Val Ala 150 155 160 165 atg atc gtc ggc ggc gca gcc atc ctc gca ttc ggt ctc ggc gcc aac 643 Met Ile Val Gly Gly Ala Ala Ile Leu Ala Phe Gly Leu Gly Ala Asn                 170 175 180 gct gaa gtt gcc ggc gta tcc aac ctc tgg gag cac ggc gga ttc ttc 691 Ala Glu Val Ala Gly Val Ser Asn Leu Trp Glu His Gly Gly Phe Phe             185 190 195 ccc aac ggt gtt gaa ggc atg atc gca gcc ttc atc ctt gtt ctc ttc 739 Pro Asn Gly Val Glu Gly Met Ile Ala Ala Phe Ile Leu Val Leu Phe         200 205 210 gca ttc ggt ggc acc gaa atc atc ggt gtt gca ggc tct gaa gct gaa 787 Ala Phe Gly Gly Thr Glu Ile Ile Gly Val Ala Gly Ser Glu Ala Glu     215 220 225 gat cct gag aag tcc atc ccc aag gct gtt aat act gtc cca gta cgc 835 Asp Pro Glu Lys Ser Ile Pro Lys Ala Val Asn Thr Val Pro Val Arg 230 235 240 245 atc ctc ctc ttc tat gtg ggt gcc atc ctg gtg atc ctt gcc ctt aat 883 Ile Leu Leu Phe Tyr Val Gly Ala Ile Leu Val Ile Leu Ala Leu Asn                 250 255 260 cct tgg cct tcc atc acc ggc gaa gaa tcc cca ttc gtc cag atc ttc 931 Pro Trp Pro Ser Ile Thr Gly Glu Glu Ser Pro Phe Val Gln Ile Phe             265 270 275 gac acc ctc ggc gtc aac tgg gct gct ggt ctc ctc aac gcc gtg gtc 979 Asp Thr Leu Gly Val Asn Trp Ala Ala Gly Leu Leu Asn Ala Val Val         280 285 290 atc acc gct gca ctg tct gcc atc aac gct gac ctc ttc ggc gct ggc 1027 Ile Thr Ala Ala Leu Ser Ala Ile Asn Ala Asp Leu Phe Gly Ala Gly     295 300 305 cgc gtt ctc act ggt ctt gcg aag gaa aac ctc gca cca aag gcc atg 1075 Arg Val Leu Thr Gly Leu Ala Lys Glu Asn Leu Ala Pro Lys Ala Met 310 315 320 325 ggc aag atc gcc aag aac ggc gtt cca gtc atg acc acc at atc atg 1123 Gly Lys Ile Ala Lys Asn Gly Val Pro Val Met Thr Thr Thr Ile Met                 330 335 340 atc atc gtc ttg atc gtg gga gta atc ctc aac gca gtg ctt ccc gag 1171 Ile Ile Val Leu Ile Val Gly Val Ile Leu Asn Ala Val Leu Pro Glu             345 350 355 cgc gtc ttc gag atc gtc gct tcc cta gca acc ttc gcc aca gtt tac 1219 Arg Val Phe Glu Ile Val Ala Ser Leu Ala Thr Phe Ala Thr Val Tyr         360 365 370 gtc tgg ctg atg atc ctg ctc gca cag gtg gga tcc cgc cga aac atg 1267 Val Trp Leu Met Ile Leu Leu Ala Gln Val Gly Ser Arg Arg Asn Met     375 380 385 cct gcc gac gag gtc aag tcc ctg aag ttc cct gtc ccc ttc tac ccc 1315 Pro Ala Asp Glu Val Lys Ser Leu Lys Phe Pro Val Pro Phe Tyr Pro 390 395 400 405 ttc gga caa tac ttc gcg atc cta ttt atc gcc ttc acc ttc ggc atc 1363 Phe Gly Gln Tyr Phe Ala Ile Leu Phe Ile Ala Phe Thr Phe Gly Ile                 410 415 420 atg gtc tgg tac gac aac tac cac ctg cca ctc gcc gtc ggc gtt gga 1411 Met Val Trp Tyr Asp Asn Tyr His Leu Pro Leu Ala Val Gly Val Gly             425 430 435 ttc ctt gtc ctg atg aca atc ctt tac tac gcc aca ggc cga cca aag 1459 Phe Leu Val Leu Met Thr Ile Leu Tyr Tyr Ala Thr Gly Arg Pro Lys         440 445 450 gcg atc gct ccg atc gat tat gaa gag cta gat ccg cga cgc gat 1504 Ala Ile Ala Pro Ile Asp Tyr Glu Glu Leu Asp Pro Arg Arg Asp     455 460 465 taatctagac tcgcacgaaa aag 1527 <210> 612 <211> 468 <212> PRT <213> Corynebacterium glutamicum <400> 612 Met Asn Ala Ser Pro Ala Pro Thr Arg Ser Phe Lys Gly Leu Arg Ala   1 5 10 15 Arg His Ile His Phe Ile Ala Leu Gly Ser Ala Ile Gly Thr Gly Leu              20 25 30 Phe Tyr Gly Ser Ala Gly Ala Ile Gln Ala Ala Gly Pro Ser Val Leu          35 40 45 Leu Val Tyr Leu Leu Gly Gly Ala Val Val Tyr Phe Met Leu Arg Ala      50 55 60 Leu Gly Glu Met Ala Val His His Pro Val Arg Gly Ser Phe Ala Val  65 70 75 80 Tyr Thr Arg Ala His Leu Gly Gly Trp Ala Gly Tyr Ile Thr Gly Trp                  85 90 95 Met Phe Ala Phe Glu Met Leu Ile Val Cys Leu Ala Asp Leu Thr Ala             100 105 110 Ile Gly Ile Tyr Met Asn Phe Trp Phe Pro Gly Thr Pro Gln Trp Thr         115 120 125 Trp Val Val Ala Thr Leu Leu Ile Val Gly Gly Ala Asn Leu Ala Ser     130 135 140 Val Arg Trp Phe Gly Glu Leu Glu Phe Ile Phe Thr Ile Ile Lys Val 145 150 155 160 Thr Ala Val Val Ala Met Ile Val Gly Gly Ala Ala Ile Leu Ala Phe                 165 170 175 Gly Leu Gly Ala Asn Ala Glu Val Ala Gly Val Ser Asn Leu Trp Glu             180 185 190 His Gly Gly Phe Phe Pro Asn Gly Val Glu Gly Met Ile Ala Ala Phe         195 200 205 Ile Leu Val Leu Phe Ala Phe Gly Gly Thr Glu Ile Ile Gly Val Ala     210 215 220 Gly Ser Glu Ala Glu Asp Pro Glu Lys Ser Ile Pro Lys Ala Val Asn 225 230 235 240 Thr Val Pro Val Arg Ile Leu Leu Phe Tyr Val Gly Ala Ile Leu Val                 245 250 255 Ile Leu Ala Leu Asn Pro Trp Pro Ser Ile Thr Gly Glu Glu Ser Pro             260 265 270 Phe Val Gln Ile Phe Asp Thr Leu Gly Val Asn Trp Ala Ala Gly Leu         275 280 285 Leu Asn Ala Val Val Ile Thr Ala Ala Leu Ser Ala Ile Asn Ala Asp     290 295 300 Leu Phe Gly Ala Gly Arg Val Leu Thr Gly Leu Ala Lys Glu Asn Leu 305 310 315 320 Ala Pro Lys Ala Met Gly Lys Ile Ala Lys Asn Gly Val Pro Val Met                 325 330 335 Thr Thr Thr Ile Met Ile Ile Val Leu Ile Val Gly Val Ile Leu Asn             340 345 350 Ala Val Leu Pro Glu Arg Val Phe Glu Ile Val Ala Ser Leu Ala Thr         355 360 365 Phe Ala Thr Val Tyr Val Trp Leu Met Ile Leu Leu Ala Gln Val Gly     370 375 380 Ser Arg Arg Asn Met Pro Ala Asp Glu Val Lys Ser Leu Lys Phe Pro 385 390 395 400 Val Pro Phe Tyr Pro Phe Gly Gln Tyr Phe Ala Ile Leu Phe Ile Ala                 405 410 415 Phe Thr Phe Gly Ile Met Val Trp Tyr Asp Asn Tyr His Leu Pro Leu             420 425 430 Ala Val Gly Val Gly Phe Leu Val Leu Met Thr Ile Leu Tyr Tyr Ala         435 440 445 Thr Gly Arg Pro Lys Ala Ile Ala Pro Ile Asp Tyr Glu Glu Leu Asp     450 455 460 Pro Arg Arg Asp 465 <210> 613 <211> 1578 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1555) <223> RXA01172 <400> 613 taaatttttc tagactaccc agattaagtg agattctttc gtgtcttcga caacttcgac 60 aacttcggcc acccgacaag agccgttgag cccgacgggt gtg ctt gcc tcg ttt 115                                             Val Leu Ala Ser Phe                                               1 5 agg ttc gcg ttt agt agc ccg cgg agg ttt cgc acc gag gtt tta gct 163 Arg Phe Ala Phe Ser Ser Pro Arg Arg Phe Arg Thr Glu Val Leu Ala                  10 15 20 ggc ctc gtg gtg gcg ctc gcg ctg att ccg gag tcg att gcg ttt tcc 211 Gly Leu Val Val Ala Leu Ala Leu Ile Pro Glu Ser Ile Ala Phe Ser              25 30 35 gta tta gct ggc gtg gat cct aag atg ggt ctt ttt gcg tcg tgc acc 259 Val Leu Ala Gly Val Asp Pro Lys Met Gly Leu Phe Ala Ser Cys Thr          40 45 50 atg gca atg acc att gcg ctt aca ggt gga cgc cct gcg atg att tcc 307 Met Ala Met Thr Ile Ala Leu Thr Gly Gly Arg Pro Ala Met Ile Ser      55 60 65 gcg gcg aca ggc gct gtg gcg ctg gtg att gca ccg gtg gtt cgg gat 355 Ala Ala Thr Gly Ala Val Ala Leu Val Ile Ala Pro Val Val Arg Asp  70 75 80 85 cat ggc gtg gaa tat ttc ctg gcc acg gta att ttg gcg ggc att att 403 His Gly Val Glu Tyr Phe Leu Ala Thr Val Ile Leu Ala Gly Ile Ile                  90 95 100 cag att gcg ttg tcg ttg ctg ggt gta gcc aag ctg atg cgg ttc att 451 Gln Ile Ala Leu Ser Leu Leu Gly Val Ala Lys Leu Met Arg Phe Ile             105 110 115 ccg cgt tcc gtt atg ctc gga ttt gtt aat gcg ctg gcg tgc ttg gtg 499 Pro Arg Ser Val Met Leu Gly Phe Val Asn Ala Leu Ala Cys Leu Val         120 125 130 ttt ttt gcg cag ctg ccg cac ctg atc gat gtt ccg tgg atg gtg tat 547 Phe Phe Ala Gln Leu Pro His Leu Ile Asp Val Pro Trp Met Val Tyr     135 140 145 ccg ctg ttc gcg ctg ggt att ggc atc atg ctg ttt tgg ccg aag ctg 595 Pro Leu Phe Ala Leu Gly Ile Gly Ile Met Leu Phe Trp Pro Lys Leu 150 155 160 165 acc tcg gtg att ccg gct ccg ctg att gtt atc gtg gcc ttg act gcg 643 Thr Ser Val Ile Pro Ala Pro Leu Ile Val Ile Val Ala Leu Thr Ala                 170 175 180 atc gtg tgg gtt ttc gga atc aac att cca aac gtc tct gac cag ggc 691 Ile Val Trp Val Phe Gly Ile Asn Ile Pro Asn Val Ser Asp Gln Gly             185 190 195 gaa ctc ccc tct tcc cta cca gaa ttc ctc att ccc aac gtt ccg ctt 739 Glu Leu Pro Ser Ser Leu Pro Glu Phe Leu Ile Pro Asn Val Pro Leu         200 205 210 act ctt gag act cta aaa att att ggg ccg tat gcg ctt gga atg tcg 787 Thr Leu Glu Thr Leu Lys Ile Ile Gly Pro Tyr Ala Leu Gly Met Ser     215 220 225 ctt gtt ggg ttg atg gaa tcg ctg ctg acc gcc aag ctg gtc gat gat 835 Leu Val Gly Leu Met Glu Ser Leu Leu Thr Ala Lys Leu Val Asp Asp 230 235 240 245 att acg gag gtt cac tcc aat aaa tcc cgc gaa gct gca ggt cag ggc 883 Ile Thr Glu Val His Ser Asn Lys Ser Arg Glu Ala Ala Gly Gln Gly                 250 255 260 atc gca aac att atc acc gcg ttt ttg ggc ggc atg ggt ggc tgc gcg 931 Ile Ala Asn Ile Ile Thr Ala Phe Leu Gly Gly Met Gly Gly Cys Ala             265 270 275 atg atc ggc cag acc atg atc aac gtg aaa aac tca gga gcc cgc act 979 Met Ile Gly Gln Thr Met Ile Asn Val Lys Asn Ser Gly Ala Arg Thr         280 285 290 cgc cta tcc acc ttc ttg gcc ggc ggc ttc ctg ctg ctc ctg gtg gtt 1027 Arg Leu Ser Thr Phe Leu Ala Gly Gly Phe Leu Leu Leu Leu Val Val     295 300 305 ttg ctg ggc gat gtc gtg ggc aaa atc ccc atg gcg gcg ctc gtg gca 1075 Leu Leu Gly Asp Val Val Gly Lys Ile Pro Met Ala Ala Leu Val Ala 310 315 320 325 gtc atg att atc gtc tcc atc gac acc gcc gac tgg cat tcg ctg aac 1123 Val Met Ile Ile Val Ser Ile Asp Thr Ala Asp Trp His Ser Leu Asn                 330 335 340 ccg cgc acc ctc aaa ttc atg ccg ctg agt gaa acg atc gtc atg ttt 1171 Pro Arg Thr Leu Lys Phe Met Pro Leu Ser Glu Thr Ile Val Met Phe             345 350 355 ata acg atc atc gcg acc ctc gtc acc gga aac ctg gcg atc ggc gtc 1219 Ile Thr Ile Ile Ala Thr Leu Val Thr Gly Asn Leu Ala Ile Gly Val         360 365 370 atc ctc gga gtg ctc acc gcc atg gtc atg ttt gct cgc cgc gtg gcc 1267 Ile Leu Gly Val Leu Thr Ala Met Val Met Phe Ala Arg Arg Val Ala     375 380 385 cac ctc gtg tct gtg gag cgc acc acc gac aac aac atc agc acc tat 1315 His Leu Val Ser Val Glu Arg Thr Thr Asp Asn Asn Ile Ser Thr Tyr 390 395 400 405 acc gtc aag ggc cag cta ttt tgg gcg tcc tcg aac gat atg gtg tac 1363 Thr Val Lys Gly Gln Leu Phe Trp Ala Ser Ser Asn Asp Met Val Tyr                 410 415 420 tcc ttc gac tac tcc gac gag gcc gag cag atc atc atc gat ctc acc 1411 Ser Phe Asp Tyr Ser Asp Glu Ala Glu Gln Ile Ile Ile Asp Leu Thr             425 430 435 gcc gca gaa atc tgg gac gcc tcc acg gta gcc acg ctg gac agc atc 1459 Ala Ala Glu Ile Trp Asp Ala Ser Thr Val Ala Thr Leu Asp Ser Ile         440 445 450 atc cac aaa tac gcc gcg cgc ggc aag agc gtg gag atc atc ggg ctc 1507 Ile His Lys Tyr Ala Ala Arg Gly Lys Ser Val Glu Ile Ile Gly Leu     455 460 465 gac ggc ccc agc cgc gat agg ctt gag cgc cta tca ggc aag ctg ggc 1555 Asp Gly Pro Ser Arg Asp Arg Leu Glu Arg Leu Ser Gly Lys Leu Gly 470 475 480 485 taaaaatttg cttatcgacg cgc 1578 <210> 614 <211> 485 <212> PRT <213> Corynebacterium glutamicum <400> 614 Val Leu Ala Ser Phe Arg Phe Ala Phe Ser Ser Pro Arg Arg Phe Arg   1 5 10 15 Thr Glu Val Leu Ala Gly Leu Val Val Ala Leu Ala Leu Ile Pro Glu              20 25 30 Ser Ile Ala Phe Ser Val Leu Ala Gly Val Asp Pro Lys Met Gly Leu          35 40 45 Phe Ala Ser Cys Thr Met Ala Met Thr Ile Ala Leu Thr Gly Gly Arg      50 55 60 Pro Ala Met Ile Ser Ala Ala Thr Gly Ala Val Ala Leu Val Ile Ala  65 70 75 80 Pro Val Val Arg Asp His Gly Val Glu Tyr Phe Leu Ala Thr Val Ile                  85 90 95 Leu Ala Gly Ile Ile Gln Ile Ala Leu Ser Leu Leu Gly Val Ala Lys             100 105 110 Leu Met Arg Phe Ile Pro Arg Ser Val Met Leu Gly Phe Val Asn Ala         115 120 125 Leu Ala Cys Leu Val Phe Phe Ala Gln Leu Pro His Leu Ile Asp Val     130 135 140 Pro Trp Met Val Tyr Pro Leu Phe Ala Leu Gly Ile Gly Ile Met Leu 145 150 155 160 Phe Trp Pro Lys Leu Thr Ser Val Ile Pro Ala Pro Leu Ile Val Ile                 165 170 175 Val Ala Leu Thr Ala Ile Val Trp Val Phe Gly Ile Asn Ile Pro Asn             180 185 190 Val Ser Asp Gln Gly Glu Leu Pro Ser Ser Leu Pro Glu Phe Leu Ile         195 200 205 Pro Asn Val Pro Leu Thr Leu Glu Thr Leu Lys Ile Ile Gly Pro Tyr     210 215 220 Ala Leu Gly Met Ser Leu Val Gly Leu Met Glu Ser Leu Leu Thr Ala 225 230 235 240 Lys Leu Val Asp Asp Ile Thr Glu Val His Ser Asn Lys Ser Arg Glu                 245 250 255 Ala Ala Gly Gln Gly Ile Ala Asn Ile Ile Thr Ala Phe Leu Gly Gly             260 265 270 Met Gly Gly Cys Ala Met Ile Gly Gln Thr Met Ile Asn Val Lys Asn         275 280 285 Ser Gly Ala Arg Thr Arg Leu Ser Thr Phe Leu Ala Gly Gly Phe Leu     290 295 300 Leu Leu Leu Val Val Leu Leu Gly Asp Val Val Gly Lys Ile Pro Met 305 310 315 320 Ala Ala Leu Val Ala Val Met Ile Ile Val Ser Ile Asp Thr Ala Asp                 325 330 335 Trp His Ser Leu Asn Pro Arg Thr Leu Lys Phe Met Pro Leu Ser Glu             340 345 350 Thr Ile Val Met Phe Ile Thr Ile Ile Ala Thr Leu Val Thr Gly Asn         355 360 365 Leu Ala Ile Gly Val Ile Leu Gly Val Leu Thr Ala Met Val Met Phe     370 375 380 Ala Arg Arg Val Ala His Leu Val Ser Val Glu Arg Thr Thr Asp Asn 385 390 395 400 Asn Ile Ser Thr Tyr Thr Val Lys Gly Gln Leu Phe Trp Ala Ser Ser                 405 410 415 Asn Asp Met Val Tyr Ser Phe Asp Tyr Ser Asp Glu Ala Glu Gln Ile             420 425 430 Ile Ile Asp Leu Thr Ala Ala Glu Ile Trp Asp Ala Ser Thr Val Ala         435 440 445 Thr Leu Asp Ser Ile Ile His Lys Tyr Ala Ala Arg Gly Lys Ser Val     450 455 460 Glu Ile Ile Gly Leu Asp Gly Pro Ser Arg Asp Arg Leu Glu Arg Leu 465 470 475 480 Ser Gly Lys Leu Gly                 485 <210> 615 <211> 1818 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1795) <223> RXA02128 <400> 615 tattagcaaa acttcttaaa gagccttttt gtgcctttat ccgagtatct ttaaaagcat 60 gagtattaag tgggcgcgct ttgtaccggg gataaccgcg atg cgg ggc tat caa 115                                             Met Arg Gly Tyr Gln                                               1 5 cga tcc tgg ttg aag ggt gat gtc atc gcg ggt ata acc gtg gcc gcg 163 Arg Ser Trp Leu Lys Gly Asp Val Ile Ala Gly Ile Thr Val Ala Ala                  10 15 20 tac ttg gtt cca caa gtc atg gct tat gcc gtc att gcg ggg ctg cca 211 Tyr Leu Val Pro Gln Val Met Ala Tyr Ala Val Ile Ala Gly Leu Pro              25 30 35 gct gtc gtt ggt ctg tgg gga gtt ctg gct ccc atg gcg ctg tac ttt 259 Ala Val Val Gly Leu Trp Gly Val Leu Ala Pro Met Ala Leu Tyr Phe          40 45 50 ttc ttg ggc acg tct cga aat ctc tcg gtt ggt cct gaa tca acc acc 307 Phe Leu Gly Thr Ser Arg Asn Leu Ser Val Gly Pro Glu Ser Thr Thr      55 60 65 gct ctg atg acg gct gca ggt gtg gga gct tta gtc ggg gca gct ggc 355 Ala Leu Met Thr Ala Ala Gly Val Gly Ala Leu Val Gly Ala Ala Gly  70 75 80 85 ggg cct gaa cga tac gca gaa gta gcg gca cta ttg gct att gca gtg 403 Gly Pro Glu Arg Tyr Ala Glu Val Ala Ala Leu Leu Ala Ile Ala Val                  90 95 100 ggc att gta tgc gct gtt ggt ttt att ggc cga ttg gga ttt ctt acc 451 Gly Ile Val Cys Ala Val Gly Phe Ile Gly Arg Leu Gly Phe Leu Thr             105 110 115 agg ctg ttg tct cga ccg gtg ctc gtt gga tat ttg atc ggt att gca 499 Arg Leu Leu Ser Arg Pro Val Leu Val Gly Tyr Leu Ile Gly Ile Ala         120 125 130 gtc ttg atg atc gtc agt cag ctg tcc aaa gtc acc cag gtg aat gtg 547 Val Leu Met Ile Val Ser Gln Leu Ser Lys Val Thr Gln Val Asn Val     135 140 145 gag agc ggt cag acg tgg cag gaa ata ata tcg ttt atc aaa gta gct 595 Glu Ser Gly Gln Thr Trp Gln Glu Ile Ile Ser Phe Ile Lys Val Ala 150 155 160 165 ggc cag gca cat att cct aca gtg att ttg gca gtc gtg gtg ttg agc 643 Gly Gln Ala His Ile Pro Thr Val Ile Leu Ala Val Val Val Leu Ser                 170 175 180 ttg ctg tat ctg gca aat tgg ttg acg cct aaa ttt ccc agc aca ctc 691 Leu Leu Tyr Leu Ala Asn Trp Leu Thr Pro Lys Phe Pro Ser Thr Leu             185 190 195 atg gtt ctt ctg ctt tcg gca gcc gcg gtg ggg ttt ttt cat ctg gat 739 Met Val Leu Leu Leu Ser Ala Ala Ala Val Gly Phe Phe His Leu Asp         200 205 210 agg ttt ggt ctt gag gtc att ggt gag gtg ccc cgt ggc ctg cct caa 787 Arg Phe Gly Leu Glu Val Ile Gly Glu Val Pro Arg Gly Leu Pro Gln     215 220 225 cca agt att ccc tcg att ggc gat cta gag atc tgg tcg ttg ttg ccc 835 Pro Ser Ile Pro Ser Ile Gly Asp Leu Glu Ile Trp Ser Leu Leu Pro 230 235 240 245 tat gcc gtg ggt att gcc atc gtt ggt ttt tca gac aat gtg ttg act 883 Tyr Ala Val Gly Ile Ala Ile Val Gly Phe Ser Asp Asn Val Leu Thr                 250 255 260 gct cgt gca ttc gcg tcg gga aaa gat gag gtg att gat tcc aac cag 931 Ala Arg Ala Phe Ala Ser Gly Lys Asp Glu Val Ile Asp Ser Asn Gln             265 270 275 gag ctg ctc gca ctg gga acc gca aac ctg gcg aat ggg ttc ttc cag 979 Glu Leu Leu Ala Leu Gly Thr Ala Asn Leu Ala Asn Gly Phe Phe Gln         280 285 290 gga ttt cct gtg tca tcg agt ggc tcc cga act gtt ctt gga gac acg 1027 Gly Phe Pro Val Ser Ser Ser Gly Ser Arg Thr Val Leu Gly Asp Thr     295 300 305 gca ggt gct cgc act cag gtg cat tca ctt gtc gtg gtg gcg ctg gtg 1075 Ala Gly Ala Arg Thr Gln Val His Ser Leu Val Val Val Ala Leu Val 310 315 320 325 atc atg gtg ctg ttg ttt gct ggt cct gtg ctc gag tct ttc cca gat 1123 Ile Met Val Leu Leu Phe Ala Gly Pro Val Leu Glu Ser Phe Pro Asp                 330 335 340 gcg gca ctt ggc gcc tta gtt att tat gca gca acg cag ttg att gat 1171 Ala Ala Leu Gly Ala Leu Val Ile Tyr Ala Ala Thr Gln Leu Ile Asp             345 350 355 atc gca gag atc aaa agg atc gca cgt ttc cgc aag agc gag ttg gtc 1219 Ile Ala Glu Ile Lys Arg Ile Ala Arg Phe Arg Lys Ser Glu Leu Val         360 365 370 atc aca gcg gct act gct gca tcc gtt gtg gct tct ggc gtg ctc gcg 1267 Ile Thr Ala Ala Thr Ala Ala Ser Val Val Ala Ser Gly Val Leu Ala     375 380 385 ggg atc ggc gtt gcg gtt acg ttg tcc atc ttg gat ctc atc aga cgt 1315 Gly Ile Gly Val Ala Val Thr Leu Ser Ile Leu Asp Leu Ile Arg Arg 390 395 400 405 att acc cga cct tat gcc gat gtc cta gga tat acg ccg ggc atg gct 1363 Ile Thr Arg Pro Tyr Ala Asp Val Leu Gly Tyr Thr Pro Gly Met Ala                 410 415 420 gga atg cac agc ttg gag gat tat cct gag tcg aca gca gtc gaa ggg 1411 Gly Met His Ser Leu Glu Asp Tyr Pro Glu Ser Thr Ala Val Glu Gly             425 430 435 ctc gtg gtt ttt aga tac gat tcc cca ctg ttt ttc gcc aac gct gat 1459 Leu Val Val Phe Arg Tyr Asp Ser Pro Leu Phe Phe Ala Asn Ala Asp         440 445 450 gat ttt tcc aaa cgt gcc atc gaa gcc gtt gat gaa gca act caa ccc 1507 Asp Phe Ser Lys Arg Ala Ile Glu Ala Val Asp Glu Ala Thr Gln Pro     455 460 465 gtg cat tgg ttt tta ctg aat gct gaa gcg aat acg gaa gtt gat ctc 1555 Val His Trp Phe Leu Leu Asn Ala Glu Ala Asn Thr Glu Val Asp Leu 470 475 480 485 acg gcc gtc gat gcc atg gaa gca ctt cgc aaa acc ctg gag gaa cgg 1603 Thr Ala Val Asp Ala Met Glu Ala Leu Arg Lys Thr Leu Glu Glu Arg                 490 495 500 ggt atc cga ttt gcg atg gcc cgg gtg aag caa gat cta cgc cga agc 1651 Gly Ile Arg Phe Ala Met Ala Arg Val Lys Gln Asp Leu Arg Arg Ser             505 510 515 ctc gag cct gca ggt ttc att gaa tcc gtg ggg gag gag tac att ttc 1699 Leu Glu Pro Ala Gly Phe Ile Glu Ser Val Gly Glu Glu Tyr Ile Phe         520 525 530 gcc aca ctc ccc act gca gtc aag ggg tat tcc gtg gag ttt cgc gat 1747 Ala Thr Leu Pro Thr Ala Val Lys Gly Tyr Ser Val Glu Phe Arg Asp     535 540 545 cgt ttt gga aac tat cca gaa ggc gtt ccg aaa gaa att ttg gaa ctt 1795 Arg Phe Gly Asn Tyr Pro Glu Gly Val Pro Lys Glu Ile Leu Glu Leu 550 555 560 565 taagctgcct ggttggcgga ctt 1818 <210> 616 <211> 565 <212> PRT <213> Corynebacterium glutamicum <400> 616 Met Arg Gly Tyr Gln Arg Ser Trp Leu Lys Gly Asp Val Ile Ala Gly   1 5 10 15 Ile Thr Val Ala Ala Tyr Leu Val Pro Gln Val Met Ala Tyr Ala Val              20 25 30 Ile Ala Gly Leu Pro Ala Val Val Gly Leu Trp Gly Val Leu Ala Pro          35 40 45 Met Ala Leu Tyr Phe Phe Leu Gly Thr Ser Arg Asn Leu Ser Val Gly      50 55 60 Pro Glu Ser Thr Thr Ala Leu Met Thr Ala Ala Gly Val Gly Ala Leu  65 70 75 80 Val Gly Ala Ala Gly Gly Pro Glu Arg Tyr Ala Glu Val Ala Ala Leu                  85 90 95 Leu Ala Ile Ala Val Gly Ile Val Cys Ala Val Gly Phe Ile Gly Arg             100 105 110 Leu Gly Phe Leu Thr Arg Leu Leu Ser Arg Pro Val Leu Val Gly Tyr         115 120 125 Leu Ile Gly Ile Ala Val Leu Met Ile Val Ser Gln Leu Ser Lys Val     130 135 140 Thr Gln Val Asn Val Glu Ser Gly Gln Thr Trp Gln Glu Ile Ile Ser 145 150 155 160 Phe Ile Lys Val Ala Gly Gln Ala His Ile Pro Thr Val Ile Leu Ala                 165 170 175 Val Val Val Leu Ser Leu Leu Tyr Leu Ala Asn Trp Leu Thr Pro Lys             180 185 190 Phe Pro Ser Thr Leu Met Val Leu Leu Leu Ser Ala Ala Ala Val Gly         195 200 205 Phe Phe His Leu Asp Arg Phe Gly Leu Glu Val Ile Gly Glu Val Pro     210 215 220 Arg Gly Leu Pro Gln Pro Ser Ile Pro Ser Ile Gly Asp Leu Glu Ile 225 230 235 240 Trp Ser Leu Leu Pro Tyr Ala Val Gly Ile Ala Ile Val Gly Phe Ser                 245 250 255 Asp Asn Val Leu Thr Ala Arg Ala Phe Ala Ser Gly Lys Asp Glu Val             260 265 270 Ile Asp Ser Asn Gln Glu Leu Leu Ala Leu Gly Thr Ala Asn Leu Ala         275 280 285 Asn Gly Phe Phe Gln Gly Phe Pro Val Ser Ser Ser Gly Ser Arg Thr     290 295 300 Val Leu Gly Asp Thr Ala Gly Ala Arg Thr Gln Val His Ser Leu Val 305 310 315 320 Val Val Ala Leu Val Ile Met Val Leu Leu Phe Ala Gly Pro Val Leu                 325 330 335 Glu Ser Phe Pro Asp Ala Ala Leu Gly Ala Leu Val Ile Tyr Ala Ala             340 345 350 Thr Gln Leu Ile Asp Ile Ala Glu Ile Lys Arg Ile Ala Arg Phe Arg         355 360 365 Lys Ser Glu Leu Val Ile Thr Ala Ala Thr Ala Ala Ser Val Val Ala     370 375 380 Ser Gly Val Leu Ala Gly Ile Gly Val Ala Val Thr Leu Ser Ile Leu 385 390 395 400 Asp Leu Ile Arg Arg Ile Thr Arg Pro Tyr Ala Asp Val Leu Gly Tyr                 405 410 415 Thr Pro Gly Met Ala Gly Met His Ser Leu Glu Asp Tyr Pro Glu Ser             420 425 430 Thr Ala Val Glu Gly Leu Val Val Phe Arg Tyr Asp Ser Pro Leu Phe         435 440 445 Phe Ala Asn Ala Asp Asp Phe Ser Lys Arg Ala Ile Glu Ala Val Asp     450 455 460 Glu Ala Thr Gln Pro Val His Trp Phe Leu Leu Asn Ala Glu Ala Asn 465 470 475 480 Thr Glu Val Asp Leu Thr Ala Val Asp Ala Met Glu Ala Leu Arg Lys                 485 490 495 Thr Leu Glu Glu Arg Gly Ile Arg Phe Ala Met Ala Arg Val Lys Gln             500 505 510 Asp Leu Arg Arg Ser Leu Glu Pro Ala Gly Phe Ile Glu Ser Val Gly         515 520 525 Glu Glu Tyr Ile Phe Ala Thr Leu Pro Thr Ala Val Lys Gly Tyr Ser     530 535 540 Val Glu Phe Arg Asp Arg Phe Gly Asn Tyr Pro Glu Gly Val Pro Lys 545 550 555 560 Glu Ile Leu Glu Leu                 565 <210> 617 <211> 1734 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (1711) <223> RXA02634 <400> 617 caacgcgaag gcttagttgt ttattaccgg ctcacctacc cggaggtcgc agactttctt 60 aaggtgagcc gctcactatt aaagaggatg gctggcgaag atg cgt gac ctt tta 115                                             Met Arg Asp Leu Leu                                               1 5 ccc tct aga gac gac tat cag cta ctc cgc ttc tcc tgg aag atg gac 163 Pro Ser Arg Asp Asp Tyr Gln Leu Leu Arg Phe Ser Trp Lys Met Asp                  10 15 20 att gct gct ggc gtc acc gtg ggc att gtt gcc ctc ccc ctc gct ctc 211 Ile Ala Ala Gly Val Thr Val Gly Ile Val Ala Leu Pro Leu Ala Leu              25 30 35 gcc ttt ggt gtg agt tct gga gtc gga gcc gag gca gga tta gtg act 259 Ala Phe Gly Val Ser Ser Gly Val Gly Ala Glu Ala Gly Leu Val Thr          40 45 50 gcg att att gct ggc ctg gtt gca gca atc ttc ggc ggt tcc aat gtg 307 Ala Ile Ile Ala Gly Leu Val Ala Ala Ile Phe Gly Ser Asn Val      55 60 65 cag gtt tca gga cca aca gga gcg atg gtg gtt gtt ctc gct cca atc 355 Gln Val Ser Gly Pro Thr Gly Ala Met Val Val Val Leu Ala Pro Ile  70 75 80 85 gtc gcc caa tat ggt gtc ggt gcg gtt gca tta ctc agc ctg atg gct 403 Val Ala Gln Tyr Gly Val Gly Ala Val Ala Leu Leu Ser Leu Met Ala                  90 95 100 gga gtt atc gtc ctt gtc gcc gga gtg ctt cga tta ggc cga acg gtg 451 Gly Val Ile Val Leu Val Ala Gly Val Leu Arg Leu Gly Arg Thr Val             105 110 115 agt ttc att ccg tgg ccg gtc atc gaa gga ttt acg gca ggc atc ggt 499 Ser Phe Ile Pro Trp Pro Val Ile Glu Gly Phe Thr Ala Gly Ile Gly         120 125 130 gtg att att ttc ctg caa cag gtg cca gct gcg ttt ggt tat tcg ggc 547 Val Ile Ile Phe Leu Gln Gln Val Pro Ala Ala Phe Gly Tyr Ser Gly     135 140 145 cat ttg ccc acc aat gcg ctc ctc gct gcg att cac act gtt tca cac 595 His Leu Pro Thr Asn Ala Leu Leu Ala Ala Ile His Thr Val Ser His 150 155 160 165 gcc acg aag gac gca att cta cct ctc tta att att atc gtc acc gct 643 Ala Thr Lys Asp Ala Ile Leu Pro Leu Leu Ile Ile Ile Val Thr Ala                 170 175 180 gcg atc atg att gtg ttg gga aag atc gcc cca aag ctc cct gcc agc 691 Ala Ile Met Ile Val Leu Gly Lys Ile Ala Pro Lys Leu Pro Ala Ser             185 190 195 ttc att gcc att ttg gtg gtg tcc att ggc gtg gct ctg ctc aag ctt 739 Phe Ile Ala Ile Leu Val Val Ser Ile Gly Val Ala Leu Leu Lys Leu         200 205 210 ccc gtt gag ttg atc ggt gag ctc ccc aat tcc ctt cct gcc cct cac 787 Pro Val Glu Leu Ile Gly Glu Leu Pro Asn Ser Leu Pro Ala Pro His     215 220 225 ctg cct gat gtg aac ctg gag atg ttc acg agt ttg ctg ggg cca gct 835 Leu Pro Asp Val Asn Leu Glu Met Phe Thr Ser Leu Leu Gly Pro Ala 230 235 240 245 ttt gct gtc gcc gcg ctc gct gct att gag tct ctc ctt tcc gct cgt 883 Phe Ala Val Ala Ala Leu Ala Ala Ile Glu Ser Leu Leu Ser Ala Arg                 250 255 260 gtg gca gcc tcc atg gcc gat acg ggt cct tat aat gct gac cgc gaa 931 Val Ala Ala Ser Met Ala Asp Thr Gly Pro Tyr Asn Ala Asp Arg Glu             265 270 275 ttg gtc ggt cag ggg ttg gcg tcg ata agc gct ggc ttt ttt ggc ggc 979 Leu Val Gly Gln Gly Leu Ala Ser Ile Ser Ala Gly Phe Phe Gly Gly         280 285 290 atg ccg gca act ggc gca atc gcg cgt acg gcg gtc aat gtg cgc tcc 1027 Met Pro Ala Thr Gly Ala Ile Ala Arg Thr Ala Val Asn Val Arg Ser     295 300 305 ggc ggg cgt acc cgt ata gcg tcg att att cac gcg ctt gtg ctg ctc 1075 Gly Gly Arg Thr Arg Ile Ala Ser Ile Ile His Ala Leu Val Leu Leu 310 315 320 325 ggc gtt gtg tat gtg gcg gcg aat atc gtt gcg gtc att ccg ctc gcc 1123 Gly Val Val Tyr Val Ala Ala Asn Ile Val Ala Val Ile Pro Leu Ala                 330 335 340 gca ctg tcg ggc gtg ctc atg gtc acc gcg agc cgc atg gtg tcc att 1171 Ala Leu Ser Gly Val Leu Met Val Thr Ala Ser Arg Met Val Ser Ile             345 350 355 gaa gtg atc tcg cgc gtc atg cgc tcc act cgc tct gat gcg atc gtt 1219 Glu Val Ile Ser Arg Val Met Arg Ser Thr Arg Ser Asp Ala Ile Val         360 365 370 ttt gtc atc acc gcg atc gtc acc atc agc gtc gac ctc gtc att gcg 1267 Phe Val Ile Thr Ala Ile Val Thr Ile Ser Val Asp Leu Val Ile Ala     375 380 385 gtc ggc atc ggc att gcc gtc gcg acg ttc ttc atg ctg cga cgc atg 1315 Val Gly Ile Gly Ile Ala Val Ala Thr Phe Phe Met Leu Arg Arg Met 390 395 400 405 agc atg aac gcc ggc gtc ttc cgg gaa acc ttg ccc gaa ccg gcc acg 1363 Ser Met Asn Ala Gly Val Phe Arg Glu Thr Leu Pro Glu Pro Ala Thr                 410 415 420 ctt aac gac gaa aag atc ggc ctt ttc cgt atc gag ggc gca ttg ttc 1411 Leu Asn Asp Glu Lys Ile Gly Leu Phe Arg Ile Glu Gly Ala Leu Phe             425 430 435 ttt ggc gca gct gaa cgt ctt tcg cag caa atc ctt gat tat gag gac 1459 Phe Gly Ala Ala Glu Arg Leu Ser Gln Gln Ile Leu Asp Tyr Glu Asp         440 445 450 ctc gaa gtg gtg atc ctg cgc ctg tca cac atc caa atg atc gac gcc 1507 Leu Glu Val Val Ile Leu Arg Leu Ser His Ile Gln Met Ile Asp Ala     455 460 465 acc ggc gcc cac cag ctc acc gag ctt gtc aat gcg ctg gaa aga aaa 1555 Thr Gly Ala His Gln Leu Thr Glu Leu Val Asn Ala Leu Glu Arg Lys 470 475 480 485 aat gtc act gta tta att aag ggc gtc cgg aaa gaa cac att cac gtt 1603 Asn Val Thr Val Leu Ile Lys Gly Val Arg Lys Glu His Ile His Val                 490 495 500 ctc ggc gtc ctc gga gcg atc aga tca ctg cgg cat gag aac cac ctc 1651 Leu Gly Val Leu Gly Ala Ile Arg Ser Leu Arg His Glu Asn His Leu             505 510 515 ttc gat gac ctt gcc cca gcg gtt gaa cat gcc cga aaa cac gtt aag 1699 Phe Asp Asp Leu Ala Pro Ala Val Glu His Ala Arg Lys His Val Lys         520 525 530 atc gac aac agt taaggcttcc ggggcgatct aaa 1734 Ile Asp Asn Ser     535 <210> 618 <211> 537 <212> PRT <213> Corynebacterium glutamicum <400> 618 Met Arg Asp Leu Leu Pro Ser Arg Asp Asp Tyr Gln Leu Leu Arg Phe   1 5 10 15 Ser Trp Lys Met Asp Ile Ala Ala Gly Val Thr Val Gly Ile Val Ala              20 25 30 Leu Pro Leu Ala Leu Ala Phe Gly Val Ser Ser Gly Val Gly Ala Glu          35 40 45 Ala Gly Leu Val Thr Ala Ile Ile Ala Gly Leu Val Ala Ala Ile Phe      50 55 60 Gly Gly Ser Asn Val Gln Val Ser Gly Pro Thr Gly Ala Met Val Val  65 70 75 80 Val Leu Ala Pro Ile Val Ala Gln Tyr Gly Val Gly Ala Val Ala Leu                  85 90 95 Leu Ser Leu Met Ala Gly Val Ile Val Leu Val Ala Gly Val Leu Arg             100 105 110 Leu Gly Arg Thr Val Ser Phe Ile Pro Trp Pro Val Ile Glu Gly Phe         115 120 125 Thr Ala Gly Ile Gly Val Ile Ile Phe Leu Gln Gln Val Pro Ala Ala     130 135 140 Phe Gly Tyr Ser Gly His Leu Pro Thr Asn Ala Leu Leu Ala Ala Ile 145 150 155 160 His Thr Val Ser His Ala Thr Lys Asp Ala Ile Leu Pro Leu Leu Ile                 165 170 175 Ile Ile Val Thr Ala Ala Ile Met Ile Val Leu Gly Lys Ile Ala Pro             180 185 190 Lys Leu Pro Ala Ser Phe Ile Ala Ile Leu Val Val Ser Ile Gly Val         195 200 205 Ala Leu Leu Lys Leu Pro Val Glu Leu Ile Gly Glu Leu Pro Asn Ser     210 215 220 Leu Pro Ala Pro His Leu Pro Asp Val Asn Leu Glu Met Phe Thr Ser 225 230 235 240 Leu Leu Gly Pro Ala Phe Ala Val Ala Ala Leu Ala Ala Ile Glu Ser                 245 250 255 Leu Leu Ser Ala Arg Val Ala Ala Ser Met Ala Asp Thr Gly Pro Tyr             260 265 270 Asn Ala Asp Arg Glu Leu Val Gly Gln Gly Leu Ala Ser Ile Ser Ala         275 280 285 Gly Phe Phe Gly Gly Met Pro Ala Thr Gly Ala Ile Ala Arg Thr Ala     290 295 300 Val Asn Val Arg Ser Gly Gly Arg Thr Arg Ile Ala Ser Ile Ile His 305 310 315 320 Ala Leu Val Leu Leu Gly Val Val Tyr Val Ala Ala Asn Ile Val Ala                 325 330 335 Val Ile Pro Leu Ala Ala Leu Ser Gly Val Leu Met Val Thr Ala Ser             340 345 350 Arg Met Val Ser Ile Glu Val Ile Ser Arg Val Met Arg Ser Thr Arg         355 360 365 Ser Asp Ala Ile Val Phe Val Ile Thr Ala Ile Val Thr Ile Ser Val     370 375 380 Asp Leu Val Ile Ala Val Gly Ile Gly Ile Ala Val Ala Thr Phe Phe 385 390 395 400 Met Leu Arg Arg Met Ser Met Asn Ala Gly Val Phe Arg Glu Thr Leu                 405 410 415 Pro Glu Pro Ala Thr Leu Asn Asp Glu Lys Ile Gly Leu Phe Arg Ile             420 425 430 Glu Gly Ala Leu Phe Phe Gly Ala Ala Glu Arg Leu Ser Gln Gln Ile         435 440 445 Leu Asp Tyr Glu Asp Leu Glu Val Val Ile Leu Arg Leu Ser His Ile     450 455 460 Gln Met Ile Asp Ala Thr Gly Ala His Gln Leu Thr Glu Leu Val Asn 465 470 475 480 Ala Leu Glu Arg Lys Asn Val Thr Val Leu Ile Lys Gly Val Arg Lys                 485 490 495 Glu His Ile His Val Leu Gly Val Leu Gly Ala Ile Arg Ser Leu Arg             500 505 510 His Glu Asn His Leu Phe Asp Asp Leu Ala Pro Ala Val Glu His Ala         515 520 525 Arg Lys His Val Lys Ile Asp Asn Ser     530 535 <210> 619 <211> 1410 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1387) <223> RXN02233 <400> 619 atccccaccc aattggccca agagctgcag agttacgttg tagaacccac ctctgcctaa 60 ctgtcgattt cccaagagcc cccttgggag tcgataatta gtg ctc gtg act tca 115                                             Val Leu Val Thr Ser                                               1 5 aca tgg gga tgg acc gtc cac gga gac ggc aaa aag atc gaa ccc ggc 163 Thr Trp Gly Trp Thr Val His Gly Asp Gly Lys Lys Ile Glu Pro Gly                  10 15 20 gca gtt gtc gct cct aaa gag cgc ctg agc tgg ggg cgc aca att gga 211 Ala Val Val Ala Pro Lys Glu Arg Leu Ser Trp Gly Arg Thr Ile Gly              25 30 35 atc ggt atg cag cac gtg atc gcc atg ttc ggc gcc acg ctc ctg gtt 259 Ile Gly Met Gln His Val Ile Ala Met Phe Gly Ala Thr Leu Leu Val          40 45 50 ccc aca ctc acc gga ttt ccg gtc aac acc aca ctt tta ttc tct ggt 307 Pro Thr Leu Thr Gly Phe Pro Val Asn Thr Thr Leu Leu Phe Ser Gly      55 60 65 ctg gga aca atc ctg ttc ctg ttg atc acc aga aac cga cta ccc tcg 355 Leu Gly Thr Ile Leu Phe Leu Leu Ile Thr Arg Asn Arg Leu Pro Ser  70 75 80 85 tac ctg ggt agt tct ttt gct ttc att gca cct tta acc gca acc caa 403 Tyr Leu Gly Ser Ser Phe Ala Phe Ile Ala Pro Leu Thr Ala Thr Gln                  90 95 100 gtc cat ggc att ggc gtg cag atc ggt ggc att ctt gtc gca ggt ctc 451 Val His Gly Ile Gly Val Gln Ile Gly Gly Ile Leu Val Ala Gly Leu             105 110 115 gtg ctc gtc gcc att gga ttt gtg gtg aaa gca gcg ggc aaa cgc gtt 499 Val Leu Val Ala Ile Gly Phe Val Val Lys Ala Ala Gly Lys Arg Val         120 125 130 att gat gct gtc atg cca ccc gct gtc acc ggt gcg atc gtg gca ctc 547 Ile Asp Ala Val Met Pro Pro Ala Val Thr Gly Ala Ile Val Ala Leu     135 140 145 atc ggc ctg aac ctg gca cca acc gcg gca gga aac ttc tcc agc caa 595 Ile Gly Leu Asn Leu Ala Pro Thr Ala Ala Gly Asn Phe Ser Ser Gln 150 155 160 165 cca ctg gtt gcc acg gcg acc ctc ttt gcc att ttg atc gct acc gtt 643 Pro Leu Val Ala Thr Ala Thr Leu Phe Ala Ile Leu Ile Ala Thr Val                 170 175 180 gca ggc cgc gga atg att gct cgc ctg ggc att ttg atc ggt gtg gtg 691 Ala Gly Arg Gly Met Ile Ala Arg Leu Gly Ile Leu Ile Gly Val Val             185 190 195 atc ggc tgg gtt ttc gca gct atc acc ggc aac ctc tca gaa ggc gca 739 Ile Gly Trp Val Phe Ala Ala Ile Thr Gly Asn Leu Ser Glu Gly Ala         200 205 210 gca gac acc atc cgt gaa gca gca tgg ttc gga ctg cca cag ttc cac 787 Ala Asp Thr Ile Arg Glu Ala Ala Trp Phe Gly Leu Pro Gln Phe His     215 220 225 aag ccg gaa ttc cag ctc tct gcc att ttg gtg aca ctg cca gtc atc 835 Lys Pro Glu Phe Gln Leu Ser Ala Ile Leu Val Thr Leu Pro Val Ile 230 235 240 245 atc gtg ctc atc gct gaa aac gtc ggc cac gtc aaa gca gtc tca gag 883 Ile Val Leu Ile Ala Glu Asn Val Gly His Val Lys Ala Val Ser Glu                 250 255 260 atg aca ggg gag gac ctc gac gac ctc gcc ggc gac gca ctt atc gca 931 Met Thr Gly Glu Asp Leu Asp Asp Leu Ala Gly Asp Ala Leu Ile Ala             265 270 275 gac gga ttc ggc acc acc ctc gca ggt gcc ttc ggt gga tcc ggc acc 979 Asp Gly Phe Gly Thr Thr Leu Ala Gly Ala Phe Gly Gly Ser Gly Thr         280 285 290 acc acc tac gca gaa aac atc ggc gtc atg gcg gcc acc cgc gta tat 1027 Thr Thr Tyr Ala Glu Asn Ile Gly Val Met Ala Ala Thr Arg Val Tyr     295 300 305 tcc acc gct gcg tac tgg gtt gcc gcg tgc act gcc atc gcc ctt gcc 1075 Ser Thr Ala Ala Tyr Trp Val Ala Ala Cys Thr Ala Ile Ala Leu Ala 310 315 320 325 ttc atc ccc aaa ttc ggt gca ctg atc ttc acc atc ccc gcc ggc gtg 1123 Phe Ile Pro Lys Phe Gly Ala Leu Ile Phe Thr Ile Pro Ala Gly Val                 330 335 340 ctg ggt ggg gca tgt ttg gtt ctt tac ggc cta atc ggt atg ctc ggc 1171 Leu Gly Gly Ala Cys Leu Val Leu Tyr Gly Leu Ile Gly Met Leu Gly             345 350 355 att cgt atc tgg caa gac aac aag gtc aac ttc aac aat cca gtg aat 1219 Ile Arg Ile Trp Gln Asp Asn Lys Val Asn Phe Asn Asn Pro Val Asn         360 365 370 ctg acc atg gct gcc gtt gct ttg gtt gca ggc att ggt aac ctc acc 1267 Leu Thr Met Ala Ala Val Ala Leu Val Ala Gly Ile Gly Asn Leu Thr     375 380 385 ctc acc gtt ttc gga gtc act ctt gaa ggc atc gca tgg ggc tct gta 1315 Leu Thr Val Phe Gly Val Thr Leu Glu Gly Ile Ala Trp Gly Ser Val 390 395 400 405 ggc atc att gtg ctg tac cca atc atg aag cgc ctg tac ctt tcc att 1363 Gly Ile Ile Val Leu Tyr Pro Ile Met Lys Arg Leu Tyr Leu Ser Ile                 410 415 420 ggg gaa ggc aag aac gca aag ttc tagtacgctg ctaaagtatg cag 1410 Gly Glu Gly Lys Asn Ala Lys Phe             425 <210> 620 <211> 429 <212> PRT <213> Corynebacterium glutamicum <400> 620 Val Leu Val Thr Ser Thr Trp Gly Trp Thr Val His Gly Asp Gly Lys   1 5 10 15 Lys Ile Glu Pro Gly Ala Val Val Ala Pro Lys Glu Arg Leu Ser Trp              20 25 30 Gly Arg Thr Ile Gly Ile Gly Met Gln His Val Ile Ala Met Phe Gly          35 40 45 Ala Thr Leu Leu Val Pro Thr Leu Thr Gly Phe Pro Val Asn Thr Thr      50 55 60 Leu Leu Phe Ser Gly Leu Gly Thr Ile Leu Phe Leu Leu Ile Thr Arg  65 70 75 80 Asn Arg Leu Pro Ser Tyr Leu Gly Ser Ser Phe Ala Phe Ile Ala Pro                  85 90 95 Leu Thr Ala Thr Gln Val His Gly Ile Gly Val Gln Ile Gly Gly Ile             100 105 110 Leu Val Ala Gly Leu Val Leu Val Ala Ile Gly Phe Val Val Lys Ala         115 120 125 Ala Gly Lys Arg Val Ile Asp Ala Val Met Pro Pro Ala Val Thr Gly     130 135 140 Ala Ile Val Ala Leu Ile Gly Leu Asn Leu Ala Pro Thr Ala Ala Gly 145 150 155 160 Asn Phe Ser Ser Gln Pro Leu Val Ala Thr Ala Thr Leu Phe Ala Ile                 165 170 175 Leu Ile Ala Thr Val Ala Gly Arg Gly Met Ile Ala Arg Leu Gly Ile             180 185 190 Leu Ile Gly Val Val Ile Gly Trp Val Phe Ala Ala Ile Thr Gly Asn         195 200 205 Leu Ser Glu Gly Ala Ala Asp Thr Ile Arg Glu Ala Ala Trp Phe Gly     210 215 220 Leu Pro Gln Phe His Lys Pro Glu Phe Gln Leu Ser Ala Ile Leu Val 225 230 235 240 Thr Leu Pro Val Ile Ile Val Leu Ile Ala Glu Asn Val Gly His Val                 245 250 255 Lys Ala Val Ser Glu Met Thr Gly Glu Asp Leu Asp Asp Leu Ala Gly             260 265 270 Asp Ala Leu Ile Ala Asp Gly Phe Gly Thr Thr Leu Ala Gly Ala Phe         275 280 285 Gly Gly Ser Gly Thr Thr Thr Tyr Ala Glu Asn Ile Gly Val Met Ala     290 295 300 Ala Thr Arg Val Tyr Ser Thr Ala Ala Tyr Trp Val Ala Ala Cys Thr 305 310 315 320 Ala Ile Ala Leu Ala Phe Ile Pro Lys Phe Gly Ala Leu Ile Phe Thr                 325 330 335 Ile Pro Ala Gly Val Leu Gly Gly Ala Cys Leu Val Leu Tyr Gly Leu             340 345 350 Ile Gly Met Leu Gly Ile Arg Ile Trp Gln Asp Asn Lys Val Asn Phe         355 360 365 Asn Asn Pro Val Asn Leu Thr Met Ala Ala Val Ala Leu Val Ala Gly     370 375 380 Ile Gly Asn Leu Thr Leu Thr Val Phe Gly Val Thr Leu Glu Gly Ile 385 390 395 400 Ala Trp Gly Ser Val Gly Ile Ile Val Leu Tyr Pro Ile Met Lys Arg                 405 410 415 Leu Tyr Leu Ser Ile Gly Glu Gly Lys Asn Ala Lys Phe             420 425 <210> 621 <211> 1335 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (101) .. (1312) <223> FRXA02233 <400> 621 atccccaccc aattggccca agagctgcag agttacgttg tagaacccac ctctgcctaa 60 ctgtcgattt cccaagagcc cccttgggag tcgataatta gtg ctc gtg act tca 115                                             Val Leu Val Thr Ser                                               1 5 aca tgg gga tgg acc gtc cac gga gac ggc aaa aag atc gaa ccc ggc 163 Thr Trp Gly Trp Thr Val His Gly Asp Gly Lys Lys Ile Glu Pro Gly                  10 15 20 gca gtt gtc gct cct aaa gag cgc ctg agc tgg ggg cgc aca att gga 211 Ala Val Val Ala Pro Lys Glu Arg Leu Ser Trp Gly Arg Thr Ile Gly              25 30 35 atc ggt atg cag cac gtg atc gcc atg ttc ggc gcc acg ctc ctg gtt 259 Ile Gly Met Gln His Val Ile Ala Met Phe Gly Ala Thr Leu Leu Val          40 45 50 ccc aca ctc acc gga ttt ccg gtc aac acc aca ctt tta ttc tct ggt 307 Pro Thr Leu Thr Gly Phe Pro Val Asn Thr Thr Leu Leu Phe Ser Gly      55 60 65 ctg gga aca atc ctg ttc ctg ttg atc acc aga aac cga cta ccc tcg 355 Leu Gly Thr Ile Leu Phe Leu Leu Ile Thr Arg Asn Arg Leu Pro Ser  70 75 80 85 tac ctg ggt agt tct ttt gct ttc att gca cct tta acc gca acc caa 403 Tyr Leu Gly Ser Ser Phe Ala Phe Ile Ala Pro Leu Thr Ala Thr Gln                  90 95 100 gtc cat ggc att ggc gtg cag atc ggt ggc att ctt gtc gca ggt ctc 451 Val His Gly Ile Gly Val Gln Ile Gly Gly Ile Leu Val Ala Gly Leu             105 110 115 gtg ctc gtc gcc att gga ttt gtg gtg aaa gca gcg ggc aaa cgc gtt 499 Val Leu Val Ala Ile Gly Phe Val Val Lys Ala Ala Gly Lys Arg Val         120 125 130 att gat gct gtc atg cca ccc gct gtc acc ggt gcg atc gtg gca ctc 547 Ile Asp Ala Val Met Pro Pro Ala Val Thr Gly Ala Ile Val Ala Leu     135 140 145 atc ggc ctg aac ctg gca cca acc gcg gca gga aac ttc tcc agc caa 595 Ile Gly Leu Asn Leu Ala Pro Thr Ala Ala Gly Asn Phe Ser Ser Gln 150 155 160 165 cca ctg gtt gcc acg gcg acc ctc ttt gcc att ttg atc gct acc gtt 643 Pro Leu Val Ala Thr Ala Thr Leu Phe Ala Ile Leu Ile Ala Thr Val                 170 175 180 gca ggc cgc gga atg att gct cgc ctg ggc att ttg atc ggt gtg gtg 691 Ala Gly Arg Gly Met Ile Ala Arg Leu Gly Ile Leu Ile Gly Val Val             185 190 195 atc ggc tgg gtt ttc gca gct atc acc ggc aac ctc tca gaa ggc gca 739 Ile Gly Trp Val Phe Ala Ala Ile Thr Gly Asn Leu Ser Glu Gly Ala         200 205 210 gca gac acc atc cgt gaa gca gca tgg ttc gga ctg cca cag ttc cac 787 Ala Asp Thr Ile Arg Glu Ala Ala Trp Phe Gly Leu Pro Gln Phe His     215 220 225 aag ccg gaa ttc cag ctc tct gcc att ttg gtg aca ctg cca gtc atc 835 Lys Pro Glu Phe Gln Leu Ser Ala Ile Leu Val Thr Leu Pro Val Ile 230 235 240 245 atc gtg ctc atc gct gaa aac gtc ggc cac gtc aaa gca gtc tca gag 883 Ile Val Leu Ile Ala Glu Asn Val Gly His Val Lys Ala Val Ser Glu                 250 255 260 atg aca ggg gag gac ctc gac gac ctc gcc ggc gac gca ctt atc gca 931 Met Thr Gly Glu Asp Leu Asp Asp Leu Ala Gly Asp Ala Leu Ile Ala             265 270 275 gac gga ttc ggc acc acc ctc gca ggt gcc ttc ggt gga tcc ggc acc 979 Asp Gly Phe Gly Thr Thr Leu Ala Gly Ala Phe Gly Gly Ser Gly Thr         280 285 290 acc acc tac gca gaa aac atc ggc gtc atg gcg gcc acc cgc gta tat 1027 Thr Thr Tyr Ala Glu Asn Ile Gly Val Met Ala Ala Thr Arg Val Tyr     295 300 305 tcc acc gct gcg tac tgg gtt gcc gcg tgc act gcc atc gcc ctt gcc 1075 Ser Thr Ala Ala Tyr Trp Val Ala Ala Cys Thr Ala Ile Ala Leu Ala 310 315 320 325 ttc atc ccc aaa ttc ggt gca ctg atc ttc acc atc ccc gcc ggc gtg 1123 Phe Ile Pro Lys Phe Gly Ala Leu Ile Phe Thr Ile Pro Ala Gly Val                 330 335 340 ctg ggt ggg gca tgt ttg gtt ctt tac ggc cta atc ggt atg ctc ggc 1171 Leu Gly Gly Ala Cys Leu Val Leu Tyr Gly Leu Ile Gly Met Leu Gly             345 350 355 att cgt atc tgg caa gac aac aag gtc aac ttc aac aat cca gtg aat 1219 Ile Arg Ile Trp Gln Asp Asn Lys Val Asn Phe Asn Asn Pro Val Asn         360 365 370 ctg acc atg gct gcc gtt gct ttg gtt gca ggc att ggt aac ctc acc 1267 Leu Thr Met Ala Ala Val Ala Leu Val Ala Gly Ile Gly Asn Leu Thr     375 380 385 ctc acc gtt ttc gga gtc act ctt gaa ggc atc gca tgg gct ctg 1312 Leu Thr Val Phe Gly Val Thr Leu Glu Gly Ile Ala Trp Ala Leu 390 395 400 taggcatcat tgtgctgtac cca 1335 <622> 622 <211> 404 <212> PRT <213> Corynebacterium glutamicum <400> 622 Val Leu Val Thr Ser Thr Trp Gly Trp Thr Val His Gly Asp Gly Lys   1 5 10 15 Lys Ile Glu Pro Gly Ala Val Val Ala Pro Lys Glu Arg Leu Ser Trp              20 25 30 Gly Arg Thr Ile Gly Ile Gly Met Gln His Val Ile Ala Met Phe Gly          35 40 45 Ala Thr Leu Leu Val Pro Thr Leu Thr Gly Phe Pro Val Asn Thr Thr      50 55 60 Leu Leu Phe Ser Gly Leu Gly Thr Ile Leu Phe Leu Leu Ile Thr Arg  65 70 75 80 Asn Arg Leu Pro Ser Tyr Leu Gly Ser Ser Phe Ala Phe Ile Ala Pro                  85 90 95 Leu Thr Ala Thr Gln Val His Gly Ile Gly Val Gln Ile Gly Gly Ile             100 105 110 Leu Val Ala Gly Leu Val Leu Val Ala Ile Gly Phe Val Val Lys Ala         115 120 125 Ala Gly Lys Arg Val Ile Asp Ala Val Met Pro Pro Ala Val Thr Gly     130 135 140 Ala Ile Val Ala Leu Ile Gly Leu Asn Leu Ala Pro Thr Ala Ala Gly 145 150 155 160 Asn Phe Ser Ser Gln Pro Leu Val Ala Thr Ala Thr Leu Phe Ala Ile                 165 170 175 Leu Ile Ala Thr Val Ala Gly Arg Gly Met Ile Ala Arg Leu Gly Ile             180 185 190 Leu Ile Gly Val Val Ile Gly Trp Val Phe Ala Ala Ile Thr Gly Asn         195 200 205 Leu Ser Glu Gly Ala Ala Asp Thr Ile Arg Glu Ala Ala Trp Phe Gly     210 215 220 Leu Pro Gln Phe His Lys Pro Glu Phe Gln Leu Ser Ala Ile Leu Val 225 230 235 240 Thr Leu Pro Val Ile Ile Val Leu Ile Ala Glu Asn Val Gly His Val                 245 250 255 Lys Ala Val Ser Glu Met Thr Gly Glu Asp Leu Asp Asp Leu Ala Gly             260 265 270 Asp Ala Leu Ile Ala Asp Gly Phe Gly Thr Thr Leu Ala Gly Ala Phe         275 280 285 Gly Gly Ser Gly Thr Thr Thr Tyr Ala Glu Asn Ile Gly Val Met Ala     290 295 300 Ala Thr Arg Val Tyr Ser Thr Ala Ala Tyr Trp Val Ala Ala Cys Thr 305 310 315 320 Ala Ile Ala Leu Ala Phe Ile Pro Lys Phe Gly Ala Leu Ile Phe Thr                 325 330 335 Ile Pro Ala Gly Val Leu Gly Gly Ala Cys Leu Val Leu Tyr Gly Leu             340 345 350 Ile Gly Met Leu Gly Ile Arg Ile Trp Gln Asp Asn Lys Val Asn Phe         355 360 365 Asn Asn Pro Val Asn Leu Thr Met Ala Ala Val Ala Leu Val Ala Gly     370 375 380 Ile Gly Asn Leu Thr Leu Thr Val Phe Gly Val Thr Leu Glu Gly Ile 385 390 395 400 Ala Trp Ala Leu <210> 623 <211> 2010 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1987) <223> RXN02372 <400> 623 gacaatactg atggataaat ttcatatcga ggacgaaggg acaaccccga acgccgtgac 60 aacatcaacc acaacccggg tgaaacatcc ggtagaccag gtg cca ccc gca ccc 115                                             Val Pro Pro Ala Pro                                               1 5 aaa ctt gca gcc cta ggg ctc caa cac gtt ctt gct ttc tac gca gga 163 Lys Leu Ala Ala Leu Gly Leu Gln His Val Leu Ala Phe Tyr Ala Gly                  10 15 20 gcc gtc att gtt ccg ctg ctg att gca cag tcg ctg aac ttg gac act 211 Ala Val Ile Val Pro Leu Leu Ile Ala Gln Ser Leu Asn Leu Asp Thr              25 30 35 gcg acc acc att cac ctg att aac gct gac ttg ttg aca tgt ggc atc 259 Ala Thr Thr Ile His Leu Ile Asn Ala Asp Leu Leu Thr Cys Gly Ile          40 45 50 gcc acg ttg att cag tct gtg ggc att ggt cgc cac att ggt gtg cgc 307 Ala Thr Leu Ile Gln Ser Val Gly Ile Gly Arg His Ile Gly Val Arg      55 60 65 cta ccg atc gtt caa ggt gtc acc act act gct gtt gct ccc atc atc 355 Leu Pro Ile Val Gln Gly Val Thr Thr Thr Ala Val Ala Pro Ile Ile  70 75 80 85 gcc att ggt ttg ggc gtt act gat ggt caa ggt ggc gtt gcg tcg ctg 403 Ala Ile Gly Leu Gly Val Thr Asp Gly Gln Gly Gly Val Ala Ser Leu                  90 95 100 cct gcc att tac ggt gca gtc att gtc tcc ggc att ttc acg ttc ttt 451 Pro Ala Ile Tyr Gly Ala Val Ile Val Ser Gly Ile Phe Thr Phe Phe             105 110 115 gca gcg ccg gtg ttt gcg cgt ttc ctc aag ttc ttc cca cca gtt gtc 499 Ala Ala Pro Val Phe Ala Arg Phe Leu Lys Phe Phe Pro Pro Val Val         120 125 130 acc ggt act gtg ctg ttg gtt atg ggt gct tcc ctg ctg tcg gta tct 547 Thr Gly Thr Val Leu Leu Val Met Gly Ala Ser Leu Leu Ser Val Ser     135 140 145 gca aat gac ttt gtg aac tac gcc gat ggg gtg cct gct gcc cgc gat 595 Ala Asn Asp Phe Val Asn Tyr Ala Asp Gly Val Pro Ala Ala Arg Asp 150 155 160 165 ctt gct tac ggt ttt ggc acc ttg gcg gtg atc att ttg gcg cag cgc 643 Leu Ala Tyr Gly Phe Gly Thr Leu Ala Val Ile Ile Leu Ala Gln Arg                 170 175 180 ttc ttc cgt gga ttc atg ggc acc ttg gct gtg ttg atc ggc ctg gtt 691 Phe Phe Arg Gly Phe Met Gly Thr Leu Ala Val Leu Ile Gly Leu Val             185 190 195 ggt ggc acc gca gtt gct ctg atc ttg ggc gat gcc aac ttg gat gag 739 Gly Gly Thr Ala Val Ala Leu Ile Leu Gly Asp Ala Asn Leu Asp Glu         200 205 210 gtg gga aat gct gaa gcg ttc gac atc acc act ccg ttt tat ttt ggt 787 Val Gly Asn Ala Glu Ala Phe Asp Ile Thr Thr Pro Phe Tyr Phe Gly     215 220 225 gtt cca gaa ttt aac gct gtt gcc att ttc tcc atg att atc gtc atg 835 Val Pro Glu Phe Asn Ala Val Ala Ile Phe Ser Met Ile Ile Val Met 230 235 240 245 atc atc acc atg gtg gag acc acc ggt gat gtg ttt gca acg ggg gaa 883 Ile Ile Thr Met Val Glu Thr Thr Gly Asp Val Phe Ala Thr Gly Glu                 250 255 260 atc gtc ggc aag cga act cgc cgc agt gat gtc acc cgc gca ctg cgc 931 Ile Val Gly Lys Arg Thr Arg Arg Ser Asp Val Thr Arg Ala Leu Arg             265 270 275 gct gac ggc ctg tcc acc ctg atg ggt ggc gtc atg aac tcc ttc ccg 979 Ala Asp Gly Leu Ser Thr Leu Met Gly Gly Val Met Asn Ser Phe Pro         280 285 290 tac acg tgc ttc gcg caa aac gtt ggc ctg gtg cgc atc acg ggc gtg 1027 Tyr Thr Cys Phe Ala Gln Asn Val Gly Leu Val Arg Ile Thr Gly Val     295 300 305 aaa tct cgc tgg gtt gcg gca gct gct gcc ggc ttc atg atc atc ctc 1075 Lys Ser Arg Trp Val Ala Ala Ala Ala Ala Gly Phe Met Ile Ile Leu 310 315 320 325 ggt gtg ctg ccc aag gct ggc gcg atc gtc gct tcc atc cct tcc cca 1123 Gly Val Leu Pro Lys Ala Gly Ala Ile Val Ala Ser Ile Pro Ser Pro                 330 335 340 gtc ctc ggt ggc gca tcc ttg gca ctg ttc gcc aac gtt gca tgg gtg 1171 Val Leu Gly Gly Ala Ser Leu Ala Leu Phe Ala Asn Val Ala Trp Val             345 350 355 ggc atc cag acc atc gcc aag tct gac ctc gct gat agc cgc aac tcc 1219 Gly Ile Gln Thr Ile Ala Lys Ser Asp Leu Ala Asp Ser Arg Asn Ser         360 365 370 gtc atc gtg acc tcc gca ctt ggc cta gcc atg ctg gtg tcc ttc cgc 1267 Val Ile Val Thr Ser Ala Leu Gly Leu Ala Met Leu Val Ser Phe Arg     375 380 385 ccc gat gtt gct cag gcg ttc cct gag tgg gcg cgt atc ttc gtc tcc 1315 Pro Asp Val Ala Gln Ala Phe Pro Glu Trp Ala Arg Ile Phe Val Ser 390 395 400 405 tcc ggc atg tcc gtc ggc gcg atc acc gcg atc ctg ctt aac ctg ctg 1363 Ser Gly Met Ser Val Gly Ala Ile Thr Ala Ile Leu Leu Asn Leu Leu                 410 415 420 ttc ttc cac gtc gga cgc caa tcc ggt gga caa gtc gct acc tca aaa 1411 Phe Phe His Val Gly Arg Gln Ser Gly Gly Gln Val Ala Thr Ser Lys             425 430 435 tcc ggt gag cgc atc aat ttg gat gcg gtc aac aag atg gat cgc acc 1459 Ser Gly Glu Arg Ile Asn Leu Asp Ala Val Asn Lys Met Asp Arg Thr         440 445 450 gac ttc gta gaa acc ttc gca ccg ctg ttc aac agc aag acc tgg cct 1507 Asp Phe Val Glu Thr Phe Ala Pro Leu Phe Asn Ser Lys Thr Trp Pro     455 460 465 ttg gaa acc gca tgg gaa tcc cag cca ttc gcc aac gtc acg gaa ctg 1555 Leu Glu Thr Ala Trp Glu Ser Gln Pro Phe Ala Asn Val Thr Glu Leu 470 475 480 485 cgc gaa gcc atc caa gtc gct gtg ctc acc gca ccg ttg tcc gac cgc 1603 Arg Glu Ala Ile Gln Val Ala Val Leu Thr Ala Pro Leu Ser Asp Arg                 490 495 500 gaa gag ctc atc cac gac tac ccc gac atg gca cag ctc att ttg gcc 1651 Glu Glu Leu Ile His Asp Tyr Pro Asp Met Ala Gln Leu Ile Leu Ala             505 510 515 acc gaa gag gaa gcc gcc acc atc tct caa gac cgt ggt tcg atc ggt 1699 Thr Glu Glu Glu Ala Ala Thr Ile Ser Gln Asp Arg Gly Ser Ile Gly         520 525 530 ctt gat gat ctc gat gac gtg gat caa gaa aag ctc atc acc gtc acc 1747 Leu Asp Asp Leu Asp Asp Val Asp Gln Glu Lys Leu Ile Thr Val Thr     535 540 545 gag cag tac cgc gaa cgg ttc aac atg ccg tat gtt gcg tac ttc gac 1795 Glu Gln Tyr Arg Glu Arg Phe Asn Met Pro Tyr Val Ala Tyr Phe Asp 550 555 560 565 acc atg gat tct gtg gat acc gtc gta gcc gcc ggc ttg cgc cgc ctc 1843 Thr Met Asp Ser Val Asp Thr Val Val Ala Ala Gly Leu Arg Arg Leu                 570 575 580 gac aac tcc gac gag cag gag cac cgc caa gcg cta tcg gaa atc att 1891 Asp Asn Ser Asp Glu Gln Glu His Arg Gln Ala Leu Ser Glu Ile Ile             585 590 595 gag att gcc aat gac cgc ttc gat ata ttg ctt gcc gac gct aac cca 1939 Glu Ile Ala Asn Asp Arg Phe Asp Ile Leu Leu Ala Asp Ala Asn Pro         600 605 610 gcc cgt tca gct ttc gat cgc aag ttt acc gag act gac ttc ctc ggc 1987 Ala Arg Ser Ala Phe Asp Arg Lys Phe Thr Glu Thr Asp Phe Leu Gly     615 620 625 taaaacacca aaaacaaatt aag 2010 <210> 624 <211> 629 <212> PRT <213> Corynebacterium glutamicum <400> 624 Val Pro Pro Ala Pro Lys Leu Ala Ala Leu Gly Leu Gln His Val Leu   1 5 10 15 Ala Phe Tyr Ala Gly Ala Val Ile Val Pro Leu Leu Ile Ala Gln Ser              20 25 30 Leu Asn Leu Asp Thr Ala Thr Thr Ile His Leu Ile Asn Ala Asp Leu          35 40 45 Leu Thr Cys Gly Ile Ala Thr Leu Ile Gln Ser Val Gly Ile Gly Arg      50 55 60 His Ile Gly Val Arg Leu Pro Ile Val Gln Gly Val Thr Thr Thr Ala  65 70 75 80 Val Ala Pro Ile Ile Ala Ile Gly Leu Gly Val Thr Asp Gly Gln Gly                  85 90 95 Gly Val Ala Ser Leu Pro Ala Ile Tyr Gly Ala Val Ile Val Ser Gly             100 105 110 Ile Phe Thr Phe Phe Ala Ala Pro Val Phe Ala Arg Phe Leu Lys Phe         115 120 125 Phe Pro Pro Val Val Thr Gly Thr Val Leu Leu Val Met Gly Ala Ser     130 135 140 Leu Leu Ser Val Ser Ala Asn Asp Phe Val Asn Tyr Ala Asp Gly Val 145 150 155 160 Pro Ala Ala Arg Asp Leu Ala Tyr Gly Phe Gly Thr Leu Ala Val Ile                 165 170 175 Ile Leu Ala Gln Arg Phe Phe Arg Gly Phe Met Gly Thr Leu Ala Val             180 185 190 Leu Ile Gly Leu Val Gly Gly Thr Ala Val Ala Leu Ile Leu Gly Asp         195 200 205 Ala Asn Leu Asp Glu Val Gly Asn Ala Glu Ala Phe Asp Ile Thr Thr     210 215 220 Pro Phe Tyr Phe Gly Val Pro Glu Phe Asn Ala Val Ala Ile Phe Ser 225 230 235 240 Met Ile Ile Val Met Ile Ile Thr Met Val Glu Thr Thr Gly Asp Val                 245 250 255 Phe Ala Thr Gly Glu Ile Val Gly Lys Arg Thr Arg Arg Ser Asp Val             260 265 270 Thr Arg Ala Leu Arg Ala Asp Gly Leu Ser Thr Leu Met Gly Gly Val         275 280 285 Met Asn Ser Phe Pro Tyr Thr Cys Phe Ala Gln Asn Val Gly Leu Val     290 295 300 Arg Ile Thr Gly Val Lys Ser Arg Trp Val Ala Ala Ala Ala Ala Gly 305 310 315 320 Phe Met Ile Ile Leu Gly Val Leu Pro Lys Ala Gly Ala Ile Val Ala                 325 330 335 Ser Ile Pro Ser Pro Val Leu Gly Gly Ala Ser Leu Ala Leu Phe Ala             340 345 350 Asn Val Ala Trp Val Gly Ile Gln Thr Ile Ala Lys Ser Asp Leu Ala         355 360 365 Asp Ser Arg Asn Ser Val Ile Val Thr Ser Ala Leu Gly Leu Ala Met     370 375 380 Leu Val Ser Phe Arg Pro Asp Val Ala Gln Ala Phe Pro Glu Trp Ala 385 390 395 400 Arg Ile Phe Val Ser Ser Gly Met Ser Val Gly Ala Ile Thr Ala Ile                 405 410 415 Leu Leu Asn Leu Leu Phe Phe His Val Gly Arg Gln Ser Gly Gly Gln             420 425 430 Val Ala Thr Ser Lys Ser Gly Glu Arg Ile Asn Leu Asp Ala Val Asn         435 440 445 Lys Met Asp Arg Thr Asp Phe Val Glu Thr Phe Ala Pro Leu Phe Asn     450 455 460 Ser Lys Thr Trp Pro Leu Glu Thr Ala Trp Glu Ser Gln Pro Phe Ala 465 470 475 480 Asn Val Thr Glu Leu Arg Glu Ala Ile Gln Val Ala Val Leu Thr Ala                 485 490 495 Pro Leu Ser Asp Arg Glu Glu Leu Ile His Asp Tyr Pro Asp Met Ala             500 505 510 Gln Leu Ile Leu Ala Thr Glu Glu Glu Ala Ala Thr Ile Ser Gln Asp         515 520 525 Arg Gly Ser Ile Gly Leu Asp Asp Leu Asp Asp Val Asp Gln Glu Lys     530 535 540 Leu Ile Thr Val Thr Glu Gln Tyr Arg Glu Arg Phe Asn Met Pro Tyr 545 550 555 560 Val Ala Tyr Phe Asp Thr Met Asp Ser Val Asp Thr Val Val Ala Ala                 565 570 575 Gly Leu Arg Arg Leu Asp Asn Ser Asp Glu Gln Glu His Arg Gln Ala             580 585 590 Leu Ser Glu Ile Ile Glu Ile Ala Asn Asp Arg Phe Asp Ile Leu Leu         595 600 605 Ala Asp Ala Asn Pro Ala Arg Ser Ala Phe Asp Arg Lys Phe Thr Glu     610 615 620 Thr Asp Phe Leu Gly 625 <210> 625 <211> 578 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (555) <223> FRXA02372 <400> 625 gat gcg gtc aac aag atg gat cgc acc gac ttc gta gaa acc ttc gca 48 Asp Ala Val Asn Lys Met Asp Arg Thr Asp Phe Val Glu Thr Phe Ala   1 5 10 15 ccg ctg ttc aac agc aag acc tgg cct ttg gaa acc gca tgg gaa tcc 96 Pro Leu Phe Asn Ser Lys Thr Trp Pro Leu Glu Thr Ala Trp Glu Ser              20 25 30 cag cca ttc gcc aac gtc acg gaa ctg cgc gaa gcc atc caa gtc gct 144 Gln Pro Phe Ala Asn Val Thr Glu Leu Arg Glu Ala Ile Gln Val Ala          35 40 45 gtg ctc acc gca ccg ttg tcc gac cgc gaa gag ctc atc cac gac tac 192 Val Leu Thr Ala Pro Leu Ser Asp Arg Glu Glu Leu Ile His Asp Tyr      50 55 60 ccc gac atg gca cag ctc att ttg gcc acc gaa gag gaa gcc gcc acc 240 Pro Asp Met Ala Gln Leu Ile Leu Ala Thr Glu Glu Glu Ala Ala Thr  65 70 75 80 atc tct caa gac cgt ggt tcg atc ggt ctt gat gat ctc gat gac gtg 288 Ile Ser Gln Asp Arg Gly Ser Ile Gly Leu Asp Asp Leu Asp Asp Val                  85 90 95 gat caa gaa aag ctc atc acc gtc acc gag cag tac cgc gaa cgg ttc 336 Asp Gln Glu Lys Leu Ile Thr Val Thr Glu Gln Tyr Arg Glu Arg Phe             100 105 110 aac atg ccg tat gtt gcg tac ttc gac acc atg gat tct gtg gat acc 384 Asn Met Pro Tyr Val Ala Tyr Phe Asp Thr Met Asp Ser Val Asp Thr         115 120 125 gtc gta gcc gcc ggc ttg cgc cgc ctc gac aac tcc gac gag cag gag 432 Val Val Ala Ala Gly Leu Arg Arg Leu Asp Asn Ser Asp Glu Gln Glu     130 135 140 cac cgc caa gcg cta tcg gaa atc att gag att gcc aat gac cgc ttc 480 His Arg Gln Ala Leu Ser Glu Ile Ile Glu Ile Ala Asn Asp Arg Phe 145 150 155 160 gat ata ttg ctt gcc gac gct aac cca gcc cgt tca gct ttc gat cgc 528 Asp Ile Leu Leu Ala Asp Ala Asn Pro Ala Arg Ser Ala Phe Asp Arg                 165 170 175 aag ttt acc gag act gac ttc ctc ggc taaaacacca aaaacaaatt 575 Lys Phe Thr Glu Thr Asp Phe Leu Gly             180 185 aag 578 <210> 626 <211> 185 <212> PRT <213> Corynebacterium glutamicum <400> 626 Asp Ala Val Asn Lys Met Asp Arg Thr Asp Phe Val Glu Thr Phe Ala   1 5 10 15 Pro Leu Phe Asn Ser Lys Thr Trp Pro Leu Glu Thr Ala Trp Glu Ser              20 25 30 Gln Pro Phe Ala Asn Val Thr Glu Leu Arg Glu Ala Ile Gln Val Ala          35 40 45 Val Leu Thr Ala Pro Leu Ser Asp Arg Glu Glu Leu Ile His Asp Tyr      50 55 60 Pro Asp Met Ala Gln Leu Ile Leu Ala Thr Glu Glu Glu Ala Ala Thr  65 70 75 80 Ile Ser Gln Asp Arg Gly Ser Ile Gly Leu Asp Asp Leu Asp Asp Val                  85 90 95 Asp Gln Glu Lys Leu Ile Thr Val Thr Glu Gln Tyr Arg Glu Arg Phe             100 105 110 Asn Met Pro Tyr Val Ala Tyr Phe Asp Thr Met Asp Ser Val Asp Thr         115 120 125 Val Val Ala Ala Gly Leu Arg Arg Leu Asp Asn Ser Asp Glu Gln Glu     130 135 140 His Arg Gln Ala Leu Ser Glu Ile Ile Glu Ile Ala Asn Asp Arg Phe 145 150 155 160 Asp Ile Leu Leu Ala Asp Ala Asn Pro Ala Arg Ser Ala Phe Asp Arg                 165 170 175 Lys Phe Thr Glu Thr Asp Phe Leu Gly             180 185 <210> 627 <211> 1314 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (1291) <223> FRXA02377 <400> 627 gacaatactg atggataaat ttcatatcga ggacgaaggg acaaccccga acgccgtgac 60 aacatcaacc acaacccggg tgaaacatcc ggtagaccag gtg cca ccc gca ccc 115                                             Val Pro Pro Ala Pro                                               1 5 aaa ctt gca gcc cta ggg ctc caa cac gtt ctt gct ttc tac gca gga 163 Lys Leu Ala Ala Leu Gly Leu Gln His Val Leu Ala Phe Tyr Ala Gly                  10 15 20 gcc gtc att gtt ccg ctg ctg att gca cag tcg ctg aac ttg gac act 211 Ala Val Ile Val Pro Leu Leu Ile Ala Gln Ser Leu Asn Leu Asp Thr              25 30 35 gcg acc acc att cac ctg att aac gct gac ttg ttg aca tgt ggc atc 259 Ala Thr Thr Ile His Leu Ile Asn Ala Asp Leu Leu Thr Cys Gly Ile          40 45 50 gcc acg ttg att cag tct gtg ggc att ggt cgc cac att ggt gtg cgc 307 Ala Thr Leu Ile Gln Ser Val Gly Ile Gly Arg His Ile Gly Val Arg      55 60 65 cta ccg atc gtt caa ggt gtc acc act act gct gtt gct ccc atc atc 355 Leu Pro Ile Val Gln Gly Val Thr Thr Thr Ala Val Ala Pro Ile Ile  70 75 80 85 gcc att ggt ttg ggc gtt act gat ggt caa ggt ggc gtt gcg tcg ctg 403 Ala Ile Gly Leu Gly Val Thr Asp Gly Gln Gly Gly Val Ala Ser Leu                  90 95 100 cct gcc att tac ggt gca gtc att gtc tcc ggc att ttc acg ttc ttt 451 Pro Ala Ile Tyr Gly Ala Val Ile Val Ser Gly Ile Phe Thr Phe Phe             105 110 115 gca gcg ccg gtg ttt gcg cgt ttc ctc aag ttc ttc cca cca gtt gtc 499 Ala Ala Pro Val Phe Ala Arg Phe Leu Lys Phe Phe Pro Pro Val Val         120 125 130 acc ggt act gtg ctg ttg gtt atg ggt gct tcc ctg ctg tcg gta tct 547 Thr Gly Thr Val Leu Leu Val Met Gly Ala Ser Leu Leu Ser Val Ser     135 140 145 gca aat gac ttt gtg aac tac gcc gat ggg gtg cct gct gcc cgc gat 595 Ala Asn Asp Phe Val Asn Tyr Ala Asp Gly Val Pro Ala Ala Arg Asp 150 155 160 165 ctt gct tac ggt ttt ggc acc ttg gcg gtg atc att ttg gcg cag cgc 643 Leu Ala Tyr Gly Phe Gly Thr Leu Ala Val Ile Ile Leu Ala Gln Arg                 170 175 180 ttc ttc cgt gga ttc atg ggc acc ttg gct gtg ttg atc ggc ctg gtt 691 Phe Phe Arg Gly Phe Met Gly Thr Leu Ala Val Leu Ile Gly Leu Val             185 190 195 ggt ggc acc gca gtt gct ctg atc ttg ggc gat gcc aac ttg gat gag 739 Gly Gly Thr Ala Val Ala Leu Ile Leu Gly Asp Ala Asn Leu Asp Glu         200 205 210 gtg gga aat gct gaa gcg ttc gac atc acc act ccg ttt tat ttt ggt 787 Val Gly Asn Ala Glu Ala Phe Asp Ile Thr Thr Pro Phe Tyr Phe Gly     215 220 225 gtt cca gaa ttt aac gct gtt gcc att ttc tcc atg att atc gtc atg 835 Val Pro Glu Phe Asn Ala Val Ala Ile Phe Ser Met Ile Ile Val Met 230 235 240 245 atc atc acc atg gtg gag acc acc ggt gat gtg ttt gca acg ggg gaa 883 Ile Ile Thr Met Val Glu Thr Thr Gly Asp Val Phe Ala Thr Gly Glu                 250 255 260 atc gtc ggc aag cga act cgc cgc agt gat gtc acc cgc gca ctg cgc 931 Ile Val Gly Lys Arg Thr Arg Arg Ser Asp Val Thr Arg Ala Leu Arg             265 270 275 gct gac ggc ctg tcc acc ctg atg ggt ggc gtc atg aac tcc ttc ccg 979 Ala Asp Gly Leu Ser Thr Leu Met Gly Gly Val Met Asn Ser Phe Pro         280 285 290 tac acg tgc ttc gcg caa aac gtt ggc ctg gtg cgc atc acg ggc gtg 1027 Tyr Thr Cys Phe Ala Gln Asn Val Gly Leu Val Arg Ile Thr Gly Val     295 300 305 aaa tct cgc tgg gtt gcg gca gct gct gcc ggc ttc atg atc atc ctc 1075 Lys Ser Arg Trp Val Ala Ala Ala Ala Ala Gly Phe Met Ile Ile Leu 310 315 320 325 ggt gtg ctg ccc aag gct ggc gcg atc gtc gct tcc atc cct tcc cca 1123 Gly Val Leu Pro Lys Ala Gly Ala Ile Val Ala Ser Ile Pro Ser Pro                 330 335 340 gtc ctc ggt ggc gca tcc ttg gca ctg ttc gcc aac gtt gca tgg gtg 1171 Val Leu Gly Gly Ala Ser Leu Ala Leu Phe Ala Asn Val Ala Trp Val             345 350 355 ggc atc cag acc atc gcc aag tct gac ctc gct gat agc cgc aac tcc 1219 Gly Ile Gln Thr Ile Ala Lys Ser Asp Leu Ala Asp Ser Arg Asn Ser         360 365 370 gtc atc gtg acc tcc gca ctt ggc cta gcc atg ctg gtg tcc ttc cgc 1267 Val Ile Val Thr Ser Ala Leu Gly Leu Ala Met Leu Val Ser Phe Arg     375 380 385 ccc gat gtt gct caa ggc gtt ccc tgagtgggcg cgtatcttcg tct 1314 Pro Asp Val Ala Gln Gly Val Pro 390 395 <210> 628 <211> 397 <212> PRT <213> Corynebacterium glutamicum <400> 628 Val Pro Pro Ala Pro Lys Leu Ala Ala Leu Gly Leu Gln His Val Leu   1 5 10 15 Ala Phe Tyr Ala Gly Ala Val Ile Val Pro Leu Leu Ile Ala Gln Ser              20 25 30 Leu Asn Leu Asp Thr Ala Thr Thr Ile His Leu Ile Asn Ala Asp Leu          35 40 45 Leu Thr Cys Gly Ile Ala Thr Leu Ile Gln Ser Val Gly Ile Gly Arg      50 55 60 His Ile Gly Val Arg Leu Pro Ile Val Gln Gly Val Thr Thr Thr Ala  65 70 75 80 Val Ala Pro Ile Ile Ala Ile Gly Leu Gly Val Thr Asp Gly Gln Gly                  85 90 95 Gly Val Ala Ser Leu Pro Ala Ile Tyr Gly Ala Val Ile Val Ser Gly             100 105 110 Ile Phe Thr Phe Phe Ala Ala Pro Val Phe Ala Arg Phe Leu Lys Phe         115 120 125 Phe Pro Pro Val Val Thr Gly Thr Val Leu Leu Val Met Gly Ala Ser     130 135 140 Leu Leu Ser Val Ser Ala Asn Asp Phe Val Asn Tyr Ala Asp Gly Val 145 150 155 160 Pro Ala Ala Arg Asp Leu Ala Tyr Gly Phe Gly Thr Leu Ala Val Ile                 165 170 175 Ile Leu Ala Gln Arg Phe Phe Arg Gly Phe Met Gly Thr Leu Ala Val             180 185 190 Leu Ile Gly Leu Val Gly Gly Thr Ala Val Ala Leu Ile Leu Gly Asp         195 200 205 Ala Asn Leu Asp Glu Val Gly Asn Ala Glu Ala Phe Asp Ile Thr Thr     210 215 220 Pro Phe Tyr Phe Gly Val Pro Glu Phe Asn Ala Val Ala Ile Phe Ser 225 230 235 240 Met Ile Ile Val Met Ile Ile Thr Met Val Glu Thr Thr Gly Asp Val                 245 250 255 Phe Ala Thr Gly Glu Ile Val Gly Lys Arg Thr Arg Arg Ser Asp Val             260 265 270 Thr Arg Ala Leu Arg Ala Asp Gly Leu Ser Thr Leu Met Gly Gly Val         275 280 285 Met Asn Ser Phe Pro Tyr Thr Cys Phe Ala Gln Asn Val Gly Leu Val     290 295 300 Arg Ile Thr Gly Val Lys Ser Arg Trp Val Ala Ala Ala Ala Ala Gly 305 310 315 320 Phe Met Ile Ile Leu Gly Val Leu Pro Lys Ala Gly Ala Ile Val Ala                 325 330 335 Ser Ile Pro Ser Pro Val Leu Gly Gly Ala Ser Leu Ala Leu Phe Ala             340 345 350 Asn Val Ala Trp Val Gly Ile Gln Thr Ile Ala Lys Ser Asp Leu Ala         355 360 365 Asp Ser Arg Asn Ser Val Ile Val Thr Ser Ala Leu Gly Leu Ala Met     370 375 380 Leu Val Ser Phe Arg Pro Asp Val Ala Gln Gly Val Pro 385 390 395 <210> 629 <211> 1512 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1489) <223> RXA02676 <400> 629 aaccattggg tattaagaaa tttgtggctt agatctcaat ttctgtatag tttgatcata 60 ctaattcatc cacttccaaa ttttcacgaa ggatcacccc atg gac acc tgg gaa 115                                             Met Asp Thr Trp Glu                                               1 5 caa acc ctt gga aca ggg cca ctg cta ggc att gca gcc ggc gcc att 163 Gln Thr Leu Gly Thr Gly Pro Leu Leu Gly Ile Ala Ala Gly Ala Ile                  10 15 20 gcc ctc atc ttg gtt ctc gtc atc gtt ttt aaa ctc cat gct ttt ctc 211 Ala Leu Ile Leu Val Leu Val Ile Val Phe Lys Leu His Ala Phe Leu              25 30 35 acc cta ata ctg gtt tca att gtt acc gca ctt gct gcc ggc att ccc 259 Thr Leu Ile Leu Val Ser Ile Val Thr Ala Leu Ala Ala Gly Ile Pro          40 45 50 gtc acc gca gta gtg gac act ctc ctt gac ggt ttt ggt aaa aca ctc 307 Val Thr Ala Val Val Asp Thr Leu Leu Asp Gly Phe Gly Lys Thr Leu      55 60 65 gcc tcg gtc gcc cta ttg gta ggc ctg ggt gcc atg ctt ggt cga ttg 355 Ala Ser Val Ala Leu Leu Val Gly Leu Gly Ala Met Leu Gly Arg Leu  70 75 80 85 gtt gaa aca tcc ggt ggc gca aaa tct cta gcc gac act atg gtg cga 403 Val Glu Thr Ser Gly Gly Ala Lys Ser Leu Ala Asp Thr Met Val Arg                  90 95 100 atc ttc ggt gaa aaa cga gca gct ttc gca ctc ggt gtc gca tcg ctg 451 Ile Phe Gly Glu Lys Arg Ala Ala Phe Ala Leu Gly Val Ala Ser Leu             105 110 115 atc atg gga ttc cct atc ttc ttc gat gct ggc ctc gtg gtc atg ctc 499 Ile Met Gly Phe Pro Ile Phe Phe Asp Ala Gly Leu Val Val Met Leu         120 125 130 cca gtg atc ttc gca gta gct cga cgc ctc aac ggc tcc gtc ctt act 547 Pro Val Ile Phe Ala Val Ala Arg Arg Leu Asn Gly Ser Val Leu Thr     135 140 145 ttt ggt atc cct gca gct ggc gcc ttc tct gtc atg cac gtg ttc gtc 595 Phe Gly Ile Pro Ala Ala Gly Ala Phe Ser Val Met His Val Phe Val 150 155 160 165 cca cct cac cca ggc cca att gca gcc tct gaa ttc ttc ggc gca caa 643 Pro Pro His Pro Gly Pro Ile Ala Ala Ser Glu Phe Phe Gly Ala Gln                 170 175 180 gtt gga tac gta cta atc gct ggc atc atc gtt gca cta ccc acc tgg 691 Val Gly Tyr Val Leu Ile Ala Gly Ile Ile Val Ala Leu Pro Thr Trp             185 190 195 tat tta acc ggt tac ctg cta ggt aag ttc tta ggc cga aag ttc ccc 739 Tyr Leu Thr Gly Tyr Leu Leu Gly Lys Phe Leu Gly Arg Lys Phe Pro         200 205 210 ctt ccc gta ccc gat cta ctc agt ggt gga gca cag gaa gat gat cag 787 Leu Pro Val Pro Asp Leu Leu Ser Gly Gly Ala Gln Glu Asp Asp Gln     215 220 225 cct cag aac cca gct aac gca gtg tcg atc att gtc att ttg ctc att 835 Pro Gln Asn Pro Ala Asn Ala Val Ser Ile Val Ile Le Le Le Le Ile 230 235 240 245 cct atg ctc ctt att ttt ggc aat acc gga aca tca atg gca gtt tcc 883 Pro Met Leu Leu Ile Phe Gly Asn Thr Gly Thr Ser Met Ala Val Ser                 250 255 260 gcc ggc ctc cta gat gca gaa tcc acc atg gtg aaa att cta gga ttc 931 Ala Gly Leu Leu Asp Ala Glu Ser Thr Met Val Lys Ile Leu Gly Phe             265 270 275 ctc ggc gaa aca cca gtg gca ctg ctc att acc ttg atc att gcc ctg 979 Leu Gly Glu Thr Pro Val Ala Leu Leu Ile Thr Leu Ile Ile Ala Leu         280 285 290 ttc ttc cta ggc aac cga cgt ggc att aat ggt tct gct cta gag aaa 1027 Phe Phe Leu Gly Asn Arg Arg Gly Ile Asn Gly Ser Ala Leu Glu Lys     295 300 305 acc atc gaa ggc gca ctc ggc cca atc tgt tca gtc gta tta atc act 1075 Thr Ile Glu Gly Ala Leu Gly Pro Ile Cys Ser Val Val Leu Ile Thr 310 315 320 325 ggc gcc ggt ggc atg ttc ggt gga gtg cta cgc acg tct gga att gga 1123 Gly Ala Gly Gly Met Phe Gly Gly Val Leu Arg Thr Ser Gly Ile Gly                 330 335 340 gga gcg ctt gca gac tcc atg gca gat cta gga ctt cca gtt atc gca 1171 Gly Ala Leu Ala Asp Ser Met Ala Asp Leu Gly Leu Pro Val Ile Ala             345 350 355 ggt tgt ttc atc gtg gca gcc gtc ctt cgt gtc gcg cag ggt tct gcc 1219 Gly Cys Phe Ile Val Ala Ala Val Leu Arg Val Ala Gln Gly Ser Ala         360 365 370 acc gtt gcg cta acc acc gcc gca gca ctc atg gca cct gct gtt gcc 1267 Thr Val Ala Leu Thr Thr Ala Ala Ala Leu Met Ala Pro Ala Val Ala     375 380 385 gct gct gac ttt aac gaa ttc cag ctt gct gcc atc gtt att tcc act 1315 Ala Ala Asp Phe Asn Glu Phe Gln Leu Ala Ala Ile Val Ile Ser Thr 390 395 400 405 gcc gct ggt tct gtt att gcc agc cac gtc aac gac tcc gga ttc tgg 1363 Ala Ala Gly Ser Val Ile Ala Ser His Val Asn Asp Ser Gly Phe Trp                 410 415 420 ctc gtt ggt cga ctc atg aac gcc gac gta ccc acc acg cta aaa act 1411 Leu Val Gly Arg Leu Met Asn Ala Asp Val Pro Thr Thr Leu Lys Thr             425 430 435 tgg acc gta aac caa acc tgc att gcg att gtg gga ttt gtg atg gcc 1459 Trp Thr Val Asn Gln Thr Cys Ile Ala Ile Val Gly Phe Val Met Ala         440 445 450 tat gca atg ttc gga ttg gca tcg ctt gca tagtccgctg accccattga 1509 Tyr Ala Met Phe Gly Leu Ala Ser Leu Ala     455 460 ttc 1512 <210> 630 <211> 463 <212> PRT <213> Corynebacterium glutamicum <400> 630 Met Asp Thr Trp Glu Gln Thr Leu Gly Thr Gly Pro Leu Leu Gly Ile   1 5 10 15 Ala Ala Gly Ala Ile Ala Leu Ile Leu Val Leu Val Ile Val Phe Lys              20 25 30 Leu His Ala Phe Leu Thr Leu Ile Leu Val Ser Ile Val Thr Ala Leu          35 40 45 Ala Ala Gly Ile Pro Val Thr Ala Val Val Asp Thr Leu Leu Asp Gly      50 55 60 Phe Gly Lys Thr Leu Ala Ser Val Ala Leu Leu Val Gly Leu Gly Ala  65 70 75 80 Met Leu Gly Arg Leu Val Glu Thr Ser Gly Gly Ala Lys Ser Leu Ala                  85 90 95 Asp Thr Met Val Arg Ile Phe Gly Glu Lys Arg Ala Ala Phe Ala Leu             100 105 110 Gly Val Ala Ser Leu Ile Met Gly Phe Pro Ile Phe Phe Asp Ala Gly         115 120 125 Leu Val Val Met Leu Pro Val Ile Phe Ala Val Ala Arg Arg Leu Asn     130 135 140 Gly Ser Val Leu Thr Phe Gly Ile Pro Ala Ala Gly Ala Phe Ser Val 145 150 155 160 Met His Val Phe Val Pro Pro His Pro Gly Pro Ile Ala Ala Ser Glu                 165 170 175 Phe Phe Gly Ala Gln Val Gly Tyr Val Leu Ile Ala Gly Ile Ile Val             180 185 190 Ala Leu Pro Thr Trp Tyr Leu Thr Gly Tyr Leu Leu Gly Lys Phe Leu         195 200 205 Gly Arg Lys Phe Pro Leu Pro Val Pro Asp Leu Leu Ser Gly Gly Ala     210 215 220 Gln Glu Asp Asp Gln Pro Gln Asn Pro Ala Asn Ala Val Ser Ile Ile 225 230 235 240 Val Ile Leu Leu Ile Pro Met Leu Leu Ile Phe Gly Asn Thr Gly Thr                 245 250 255 Ser Met Ala Val Ser Ala Gly Leu Leu Asp Ala Glu Ser Thr Met Val             260 265 270 Lys Ile Leu Gly Phe Leu Gly Glu Thr Pro Val Ala Leu Leu Ile Thr         275 280 285 Leu Ile Ile Ala Leu Phe Phe Leu Gly Asn Arg Arg Gly Ile Asn Gly     290 295 300 Ser Ala Leu Glu Lys Thr Ile Glu Gly Ala Leu Gly Pro Ile Cys Ser 305 310 315 320 Val Val Leu Ile Thr Gly Ala Gly Gly Met Phe Gly Gly Val Leu Arg                 325 330 335 Thr Ser Gly Ile Gly Gly Ala Leu Ala Asp Ser Met Ala Asp Leu Gly             340 345 350 Leu Pro Val Ile Ala Gly Cys Phe Ile Val Ala Ala Val Leu Arg Val         355 360 365 Ala Gln Gly Ser Ala Thr Val Ala Leu Thr Thr Ala Ala Ala Leu Met     370 375 380 Ala Pro Ala Val Ala Ala Ala Asp Phe Asn Glu Phe Gln Leu Ala Ala 385 390 395 400 Ile Val Ile Ser Thr Ala Ala Gly Ser Val Ile Ala Ser His Val Asn                 405 410 415 Asp Ser Gly Phe Trp Leu Val Gly Arg Leu Met Asn Ala Asp Val Pro             420 425 430 Thr Thr Leu Lys Thr Trp Thr Val Asn Gln Thr Cys Ile Ala Ile Val         435 440 445 Gly Phe Val Met Ala Tyr Ala Met Phe Gly Leu Ala Ser Leu Ala     450 455 460 <210> 631 <211> 1608 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (101) .. (1585) <223> RXN00432 <400> 631 agctaatctg ccttgcttta cacctccggg ctataacaat ccagtgccag tggctaggga 60 tttactaaaa atcgggtaac acgcgcgtag tatttttcgc atg gaa tta ttg gag 115                                             Met Glu Leu Leu Glu                                               1 5 acc ttc atc act gat gtc att aat gac aat ttg tgg atg atc ttg ccc 163 Thr Phe Ile Thr Asp Val Ile Asn Asp Asn Leu Trp Met Ile Leu Pro                  10 15 20 ttc ttg ctc gtt gct gct ggc ctc tat ttc ggt ggg cgt acg ttg ctg 211 Phe Leu Leu Val Ala Ala Gly Leu Tyr Phe Gly Gly Arg Thr Leu Leu              25 30 35 gtt cag att cgg atg att ccg gag atg ttc aaa gcg gtc gtc gag aag 259 Val Gln Ile Arg Met Ile Pro Glu Met Phe Lys Ala Val Val Glu Lys          40 45 50 cct gcg aag gat ggg gag ttc gcg gac aag cag gac att tcg gct ttt 307 Pro Ala Lys Asp Gly Glu Phe Ala Asp Lys Gln Asp Ile Ser Ala Phe      55 60 65 aag gcg ttc acg att tct gcg gcg tcg cga gtt ggt acg gcg aat gtt 355 Lys Ala Phe Thr Ile Ser Ala Ala Ser Arg Val Gly Thr Ala Asn Val  70 75 80 85 gcg ggt gtt gcg ctg gcg atc act ctg ggt gga ccg ggt gca gtg ttc 403 Ala Gly Val Ala Leu Ala Ile Thr Leu Gly Gly Pro Gly Ala Val Phe                  90 95 100 tgg atg tgg atc att gcg ctg gtt ggc ggt gcg aca tcg ttc att gag 451 Trp Met Trp Ile Ile Ala Leu Val Gly Gly Ala Thr Ser Phe Ile Glu             105 110 115 tcg act ctt gga cag ttg tgg aag gtg aag gac ggc gac agc tat cgc 499 Ser Thr Leu Gly Gln Leu Trp Lys Val Lys Asp Gly Asp Ser Tyr Arg         120 125 130 ggt ggc cct gcg tac tac atg acg ctt ggt ttg aat gct cgg tgg ctt 547 Gly Gly Pro Ala Tyr Tyr Met Thr Leu Gly Leu Asn Ala Arg Trp Leu     135 140 145 gcg gtt gtt ttc ggt gtc gcc atc acg ttg acc ttt ggt ttt gtg tac 595 Ala Val Val Phe Gly Val Ala Ile Thr Leu Thr Phe Gly Phe Val Tyr 150 155 160 165 aac gct ttg cag tcc aac gcg gtt gtt gag gcg att acg gta tca ctc 643 Asn Ala Leu Gln Ser Asn Ala Val Val Glu Ala Ile Thr Val Ser Leu                 170 175 180 ggc acc cct tct acc act gca aag gct ttt gtt ggc ttg ggc atg gct 691 Gly Thr Pro Ser Thr Thr Ala Lys Ala Phe Val Gly Leu Gly Met Ala             185 190 195 gga ttg tct gcg ctg gtt att ttt ggc ggc gtg cag cgt atc gca aac 739 Gly Leu Ser Ala Leu Val Ile Phe Gly Gly Val Gln Arg Ile Ala Asn         200 205 210 gtg acg cag tgg atg gtt ccg ttc atg gcg ggt gcg tac atc att gtg 787 Val Thr Gln Trp Met Val Pro Phe Met Ala Gly Ala Tyr Ile Ile Val     215 220 225 ggt gtg gtg gtg att gtg att aac att cag cag gtt ccg acc atg atc 835 Gly Val Val Val Ile Val Ile Asn Ile Gln Gln Val Pro Thr Met Ile 230 235 240 245 aac gac atc att gct ggt gct ttt ggt ttc cgt ccg gtt gct act gcg 883 Asn Asp Ile Ile Ala Gly Ala Phe Gly Phe Arg Pro Val Ala Thr Ala                 250 255 260 tcg gtg tgg ggc gcg ttc tgg ttg gcg ttt atg aac ggt atg cgc cgt 931 Ser Val Trp Gly Ala Phe Trp Leu Ala Phe Met Asn Gly Met Arg Arg             265 270 275 gga ctg ttc tcc aat gag gct ggt gag ggt tct gtc ccg aac gct gct 979 Gly Leu Phe Ser Asn Glu Ala Gly Glu Gly Ser Val Pro Asn Ala Ala         280 285 290 gct acc gcg act gtg tct cac cct gtg aag cag ggt ttg gtt cag act 1027 Ala Thr Ala Thr Val Ser His Pro Val Lys Gln Gly Leu Val Gln Thr     295 300 305 ctg ggc gta tat ttc gac acc ctg ctc gtt tgt agc att acc gct ttt 1075 Leu Gly Val Tyr Phe Asp Thr Leu Leu Val Cys Ser Ile Thr Ala Phe 310 315 320 325 gtc atc ctg ctg tct gga gtg gag tac gcg acc ggc gat att cag tct 1123 Val Ile Leu Leu Ser Gly Val Glu Tyr Ala Thr Gly Asp Ile Gln Ser                 330 335 340 tct tct ttg act cag tcc gcg ctg gct agc gtt gtt ggt ggt tgg gga 1171 Ser Ser Leu Thr Gln Ser Ala Leu Ala Ser Val Val Gly Gly Trp Gly             345 350 355 acc cac ttc att acc gta gtg atg ttc ttc ctg gcg ttt tct tcc gtg 1219 Thr His Phe Ile Thr Val Val Met Phe Phe Leu Ala Phe Ser Ser Val         360 365 370 ctg ggt aac tac tac ttg gca cag gcg aat att cag tac ttc acc gat 1267 Leu Gly Asn Tyr Tyr Leu Ala Gln Ala Asn Ile Gln Tyr Phe Thr Asp     375 380 385 tcg aag act gtc atg act gtt ttc cga ctc ttg gtg ctg ctc agc gtg 1315 Ser Lys Thr Val Met Thr Val Phe Arg Leu Leu Val Leu Leu Ser Val 390 395 400 405 ttc tct ggc gcg gtt gct tcg gtg ccg ttg atc tgg gct ttg ggt gat 1363 Phe Ser Gly Ala Val Ala Ser Val Pro Leu Ile Trp Ala Leu Gly Asp                 410 415 420 act ttc gct ggc atc atg gtg ctc att aac ctg gcg gcg atc att ccg 1411 Thr Phe Ala Gly Ile Met Val Leu Ile Asn Leu Ala Ala Ile Ile Pro             425 430 435 ctg ggt ggc gtt gca gtg aag ttg ctt aag aat tac acc att cag aag 1459 Leu Gly Gly Val Ala Val Lys Leu Leu Lys Asn Tyr Thr Ile Gln Lys         440 445 450 aag gct ggt ctg gat cct gtg ttc cac cgc gac atg atg cca gag gtt 1507 Lys Ala Gly Leu Asp Pro Val Phe His Arg Asp Met Met Pro Glu Val     455 460 465 cgt aat att gcg tgc tgg aac ggc aaa gat gca gct aca tcc aac tat 1555 Arg Asn Ile Ala Cys Trp Asn Gly Lys Asp Ala Ala Thr Ser Asn Tyr 470 475 480 485 cac gaa gcg atg gaa gtg atc aag aag agc tagtcatcga aggaacagtg 1605 His Glu Ala Met Glu Val Ile Lys Lys Ser                 490 495 gta 1608 <210> 632 <211> 495 <212> PRT <213> Corynebacterium glutamicum <400> 632 Met Glu Leu Leu Glu Thr Phe Ile Thr Asp Val Ile Asn Asp Asn Leu   1 5 10 15 Trp Met Ile Leu Pro Phe Leu Leu Val Ala Ala Gly Leu Tyr Phe Gly              20 25 30 Gly Arg Thr Leu Leu Val Gln Ile Arg Met Ile Pro Glu Met Phe Lys          35 40 45 Ala Val Val Glu Lys Pro Ala Lys Asp Gly Glu Phe Ala Asp Lys Gln      50 55 60 Asp Ile Ser Ala Phe Lys Ala Phe Thr Ile Ser Ala Ala Ser Arg Val  65 70 75 80 Gly Thr Ala Asn Val Ala Gly Val Ala Leu Ala Ile Thr Leu Gly Gly                  85 90 95 Pro Gly Ala Val Phe Trp Met Trp Ile Ile Ala Leu Val Gly Gly Ala             100 105 110 Thr Ser Phe Ile Glu Ser Thr Leu Gly Gln Leu Trp Lys Val Lys Asp         115 120 125 Gly Asp Ser Tyr Arg Gly Gly Pro Ala Tyr Tyr Met Thr Leu Gly Leu     130 135 140 Asn Ala Arg Trp Leu Ala Val Val Phe Gly Val Ala Ile Thr Leu Thr 145 150 155 160 Phe Gly Phe Val Tyr Asn Ala Leu Gln Ser Asn Ala Val Val Glu Ala                 165 170 175 Ile Thr Val Ser Leu Gly Thr Pro Ser Thr Thr Ala Lys Ala Phe Val             180 185 190 Gly Leu Gly Met Ala Gly Leu Ser Ala Leu Val Ile Phe Gly Gly Val         195 200 205 Gln Arg Ile Ala Asn Val Thr Gln Trp Met Val Pro Phe Met Ala Gly     210 215 220 Ala Tyr Ile Ile Val Gly Val Val Val Ile Val Ile Asn Ile Gln Gln 225 230 235 240 Val Pro Thr Met Ile Asn Asp Ile Ile Ala Gly Ala Phe Gly Phe Arg                 245 250 255 Pro Val Ala Thr Ala Ser Val Trp Gly Ala Phe Trp Leu Ala Phe Met             260 265 270 Asn Gly Met Arg Arg Gly Leu Phe Ser Asn Glu Ala Gly Glu Gly Ser         275 280 285 Val Pro Asn Ala Ala Ala Thr Ala Thr Val Ser His Pro Val Lys Gln     290 295 300 Gly Leu Val Gln Thr Leu Gly Val Tyr Phe Asp Thr Leu Leu Val Cys 305 310 315 320 Ser Ile Thr Ala Phe Val Ile Leu Leu Ser Gly Val Glu Tyr Ala Thr                 325 330 335 Gly Asp Ile Gln Ser Ser Ser Leu Thr Gln Ser Ala Leu Ala Ser Val             340 345 350 Val Gly Gly Trp Gly Thr His Phe Ile Thr Val Val Met Phe Phe Leu         355 360 365 Ala Phe Ser Ser Val Leu Gly Asn Tyr Tyr Leu Ala Gln Ala Asn Ile     370 375 380 Gln Tyr Phe Thr Asp Ser Lys Thr Val Met Thr Val Phe Arg Leu Leu 385 390 395 400 Val Leu Leu Ser Val Phe Ser Gly Ala Val Ala Ser Val Pro Leu Ile                 405 410 415 Trp Ala Leu Gly Asp Thr Phe Ala Gly Ile Met Val Leu Ile Asn Leu             420 425 430 Ala Ala Ile Ile Pro Leu Gly Gly Val Ala Val Lys Leu Leu Lys Asn         435 440 445 Tyr Thr Ile Gln Lys Lys Ala Gly Leu Asp Pro Val Phe His Arg Asp     450 455 460 Met Met Pro Glu Val Arg Asn Ile Ala Cys Trp Asn Gly Lys Asp Ala 465 470 475 480 Ala Thr Ser Asn Tyr His Glu Ala Met Glu Val Ile Lys Lys Ser                 485 490 495 <210> 633 <211> 914 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (891) <223> FRXA00432 <400> 633 ttg tct gcg ctg gtt att ttt ggc ggc gtg cag cgt atc gca aac gtg 48 Leu Ser Ala Leu Val Ile Phe Gly Gly Val Gln Arg Ile Ala Asn Val   1 5 10 15 acg cag tgg atg gtt ccg ttc atg gcg ggt gcg tac atc att gtg ggt 96 Thr Gln Trp Met Val Pro Phe Met Ala Gly Ala Tyr Ile Ile Val Gly              20 25 30 gtg gtg gtg att gtg att aac att cag cag gtt ccg acc atg atc aac 144 Val Val Val Ile Val Ile Asn Ile Gln Gln Val Pro Thr Met Ile Asn          35 40 45 gac atc att gct ggt gct ttt ggt ttc cgt ccg gtt gct act gcg tcg 192 Asp Ile Ile Ala Gly Ala Phe Gly Phe Arg Pro Val Ala Thr Ala Ser      50 55 60 gtg tgg ggc gcg ttc tgg ttg gcg ttt atg aac ggt atg cgc cgt gga 240 Val Trp Gly Ala Phe Trp Leu Ala Phe Met Asn Gly Met Arg Arg Gly  65 70 75 80 ctg ttc tcc aat gag gct ggt gag ggt tct gtc ccg aac gct gct gct 288 Leu Phe Ser Asn Glu Ala Gly Glu Gly Ser Val Pro Asn Ala Ala Ala                  85 90 95 acc gcg act gtg tct cac cct gtg aag cag ggt ttg gtt cag act ctg 336 Thr Ala Thr Val Ser His Pro Val Lys Gln Gly Leu Val Gln Thr Leu             100 105 110 ggc gta tat ttc gac acc ctg ctc gtt tgt agc att acc gct ttt gtc 384 Gly Val Tyr Phe Asp Thr Leu Leu Val Cys Ser Ile Thr Ala Phe Val         115 120 125 atc ctg ctg tct gga gtg gag tac gcg acc ggc gat att cag tct tct 432 Ile Leu Leu Ser Gly Val Glu Tyr Ala Thr Gly Asp Ile Gln Ser Ser     130 135 140 tct ttg act cag tcc gcg ctg gct agc gtt gtt ggt ggt tgg gga acc 480 Ser Leu Thr Gln Ser Ala Leu Ala Ser Val Val Gly Gly Trp Gly Thr 145 150 155 160 cac ttc att acc gta gtg atg ttc ttc ctg gcg ttt tct tcc gtg ctg 528 His Phe Ile Thr Val Val Met Phe Phe Leu Ala Phe Ser Ser Val Leu                 165 170 175 ggt aac tac tac ttg gca cag gcg aat att cag tac ttc acc gat tcg 576 Gly Asn Tyr Tyr Leu Ala Gln Ala Asn Ile Gln Tyr Phe Thr Asp Ser             180 185 190 aag act gtc atg act gtt ttc cga ctc ttg gtg ctg ctc agc gtg ttc 624 Lys Thr Val Met Thr Val Phe Arg Leu Leu Val Leu Leu Ser Val Phe         195 200 205 tct ggc gcg gtt gct tcg gtg ccg ttg atc tgg gct ttg ggt gat act 672 Ser Gly Ala Val Ala Ser Val Pro Leu Ile Trp Ala Leu Gly Asp Thr     210 215 220 ttc gct ggc atc atg gtg ctc att aac ctg gcg gcg atc att ccg ctg 720 Phe Ala Gly Ile Met Val Leu Ile Asn Leu Ala Ala Ile Ile Pro Leu 225 230 235 240 ggt ggc gtt gca gtg aag ttg ctt aag aat tac acc att cag aag aag 768 Gly Gly Val Ala Val Lys Leu Leu Lys Asn Tyr Thr Ile Gln Lys Lys                 245 250 255 gct ggt ctg gat cct gtg ttc cac cgc gac atg atg cca gag gtt cgt 816 Ala Gly Leu Asp Pro Val Phe His Arg Asp Met Met Pro Glu Val Arg             260 265 270 aat att gcg tgc tgg aac ggc aaa gat gca gct aca tcc aac tat cac 864 Asn Ile Ala Cys Trp Asn Gly Lys Asp Ala Ala Thr Ser Asn Tyr His         275 280 285 gaa gcg atg gaa gtg atc aag aag agc tagtcatcga aggaacagtg 911 Glu Ala Met Glu Val Ile Lys Lys Ser     290 295 gta 914 <210> 634 <211> 297 <212> PRT <213> Corynebacterium glutamicum <400> 634 Leu Ser Ala Leu Val Ile Phe Gly Gly Val Gln Arg Ile Ala Asn Val   1 5 10 15 Thr Gln Trp Met Val Pro Phe Met Ala Gly Ala Tyr Ile Ile Val Gly              20 25 30 Val Val Val Ile Val Ile Asn Ile Gln Gln Val Pro Thr Met Ile Asn          35 40 45 Asp Ile Ile Ala Gly Ala Phe Gly Phe Arg Pro Val Ala Thr Ala Ser      50 55 60 Val Trp Gly Ala Phe Trp Leu Ala Phe Met Asn Gly Met Arg Arg Gly  65 70 75 80 Leu Phe Ser Asn Glu Ala Gly Glu Gly Ser Val Pro Asn Ala Ala Ala                  85 90 95 Thr Ala Thr Val Ser His Pro Val Lys Gln Gly Leu Val Gln Thr Leu             100 105 110 Gly Val Tyr Phe Asp Thr Leu Leu Val Cys Ser Ile Thr Ala Phe Val         115 120 125 Ile Leu Leu Ser Gly Val Glu Tyr Ala Thr Gly Asp Ile Gln Ser Ser     130 135 140 Ser Leu Thr Gln Ser Ala Leu Ala Ser Val Val Gly Gly Trp Gly Thr 145 150 155 160 His Phe Ile Thr Val Val Met Phe Phe Leu Ala Phe Ser Ser Val Leu                 165 170 175 Gly Asn Tyr Tyr Leu Ala Gln Ala Asn Ile Gln Tyr Phe Thr Asp Ser             180 185 190 Lys Thr Val Met Thr Val Phe Arg Leu Leu Val Leu Leu Ser Val Phe         195 200 205 Ser Gly Ala Val Ala Ser Val Pro Leu Ile Trp Ala Leu Gly Asp Thr     210 215 220 Phe Ala Gly Ile Met Val Leu Ile Asn Leu Ala Ala Ile Ile Pro Leu 225 230 235 240 Gly Gly Val Ala Val Lys Leu Leu Lys Asn Tyr Thr Ile Gln Lys Lys                 245 250 255 Ala Gly Leu Asp Pro Val Phe His Arg Asp Met Met Pro Glu Val Arg             260 265 270 Asn Ile Ala Cys Trp Asn Gly Lys Asp Ala Ala Thr Ser Asn Tyr His         275 280 285 Glu Ala Met Glu Val Ile Lys Lys Ser     290 295 <210> 635 <211> 569 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (45) .. (569) <223> FRXA00436 <400> 635 gggatttact aaaaatcggg taacacgcgc gtagtatttt tcgc atg gaa tta ttg 56                                                  Met glu leu leu                                                    One gag acc ttc atc act gat gtc att aat gac aat ttg tgg atg atc ttg 104 Glu Thr Phe Ile Thr Asp Val Ile Asn Asp Asn Leu Trp Met Ile Leu   5 10 15 20 ccc ttc ttg ctc gtt gct gct ggc ctc tat ttc ggt ggg cgt acg ttg 152 Pro Phe Leu Leu Val Ala Ala Gly Leu Tyr Phe Gly Gly Arg Thr Leu                  25 30 35 ctg gtt cag att cgg atg att ccg gag atg ttc aaa gcg gtc gtc gag 200 Leu Val Gln Ile Arg Met Ile Pro Glu Met Phe Lys Ala Val Val Glu              40 45 50 aag cct gcg aag gat ggg gag ttc gcg gac aag cag gac att tcg gct 248 Lys Pro Ala Lys Asp Gly Glu Phe Ala Asp Lys Gln Asp Ile Ser Ala          55 60 65 ttt aag gcg ttc acg att tct gcg gcg tcg cga gtt ggt acg gcg aat 296 Phe Lys Ala Phe Thr Ile Ser Ala Ala Ser Arg Val Gly Thr Ala Asn      70 75 80 gtt gcg ggt gtt gcg ctg gcg atc act ctg ggt gga ccg ggt gca gtg 344 Val Ala Gly Val Ala Leu Ala Ile Thr Leu Gly Gly Pro Gly Ala Val  85 90 95 100 ttc tgg atg tgg atc att gcg ctg gtt ggc ggt gcg aca tcg ttc att 392 Phe Trp Met Trp Ile Ile Ala Leu Val Gly Gly Ala Thr Ser Phe Ile                 105 110 115 gag tcg act ctt gga cag ttg tgg aag gtg aag gac ggc gac agc tat 440 Glu Ser Thr Leu Gly Gln Leu Trp Lys Val Lys Asp Gly Asp Ser Tyr             120 125 130 cgc ggt ggc cct gcg tac tac atg acg ctt ggt ttg aat gct cgg tgg 488 Arg Gly Gly Pro Ala Tyr Tyr Met Thr Leu Gly Leu Asn Ala Arg Trp         135 140 145 ctt gcg gtt gtt ttc ggt gtc gcc atc acg ttg acc ttt ggt ttt gtg 536 Leu Ala Val Val Phe Gly Val Ala Ile Thr Leu Thr Phe Gly Phe Val     150 155 160 tac aac gct ttg cag tcc aac gcg gtt gtt gag 569 Tyr Asn Ala Leu Gln Ser Asn Ala Val Val Glu 165 170 175 <210> 636 <211> 175 <212> PRT <213> Corynebacterium glutamicum <400> 636 Met Glu Leu Leu Glu Thr Phe Ile Thr Asp Val Ile Asn Asp Asn Leu   1 5 10 15 Trp Met Ile Leu Pro Phe Leu Leu Val Ala Ala Gly Leu Tyr Phe Gly              20 25 30 Gly Arg Thr Leu Leu Val Gln Ile Arg Met Ile Pro Glu Met Phe Lys          35 40 45 Ala Val Val Glu Lys Pro Ala Lys Asp Gly Glu Phe Ala Asp Lys Gln      50 55 60 Asp Ile Ser Ala Phe Lys Ala Phe Thr Ile Ser Ala Ala Ser Arg Val  65 70 75 80 Gly Thr Ala Asn Val Ala Gly Val Ala Leu Ala Ile Thr Leu Gly Gly                  85 90 95 Pro Gly Ala Val Phe Trp Met Trp Ile Ile Ala Leu Val Gly Gly Ala             100 105 110 Thr Ser Phe Ile Glu Ser Thr Leu Gly Gln Leu Trp Lys Val Lys Asp         115 120 125 Gly Asp Ser Tyr Arg Gly Gly Pro Ala Tyr Tyr Met Thr Leu Gly Leu     130 135 140 Asn Ala Arg Trp Leu Ala Val Val Phe Gly Val Ala Ile Thr Leu Thr 145 150 155 160 Phe Gly Phe Val Tyr Asn Ala Leu Gln Ser Asn Ala Val Val Glu                 165 170 175 <637> 637 <211> 1572 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1549) <223> RXA00847 <400> 637 tctggcccgc tgtgtcctct ggacgcagcg ggccagtagt attttggggg tgagaataag 60 gtttggaatt ctaagtgttg tcgcctgcac ggtttcgttg gtg gca tgt cag gct 115                                             Val Ala Cys Gln Ala                                               1 5 aat ccg ggt cct gcg ccc gtt gag gag cca act aca gcc act gcg acg 163 Asn Pro Gly Pro Ala Pro Val Glu Glu Pro Thr Thr Ala Thr Ala Thr                  10 15 20 acc acg gca act gag acg acc acc gta gag act gaa gcc ccc aaa caa 211 Thr Thr Ala Thr Glu Thr Thr Thr Val Glu Thr Glu Ala Pro Lys Gln              25 30 35 gat cgg gaa acc atc agt att ggt atc gat ccg atc cgc aac ggt ttc 259 Asp Arg Glu Thr Ile Ser Ile Gly Ile Asp Pro Ile Arg Asn Gly Phe          40 45 50 aat cca cat ttg ttg tct gat gat tct cca ctg gtg cgc gat act gca 307 Asn Pro His Leu Leu Ser Asp Asp Ser Pro Leu Val Arg Asp Thr Ala      55 60 65 tcg ttg gtg ttg ccg agt gct ttt gag ggc aat cag ctg aac act gac 355 Ser Leu Val Leu Pro Ser Ala Phe Glu Gly Asn Gln Leu Asn Thr Asp  70 75 80 85 ttg ttg gac aat gtt gag cag gtg gat gaa acc acg gtg agg tac acg 403 Leu Leu Asp Asn Val Glu Gln Val Asp Glu Thr Thr Val Arg Tyr Thr                  90 95 100 att gct cag gaa gcg cag tgg agt gat ggc act ccg att act ggg tct 451 Ile Ala Gln Glu Ala Gln Trp Ser Asp Gly Thr Pro Ile Thr Gly Ser             105 110 115 gat ttt gag tac ttg cgc agg tcc att gtg gcg ggg aca gga acg ctg 499 Asp Phe Glu Tyr Leu Arg Arg Ser Ile Val Ala Gly Thr Gly Thr Leu         120 125 130 aac gat tct gca tat tcg gcg att tca gag att agg acc tca ggc ggt 547 Asn Asp Ser Ala Tyr Ser Ala Ile Ser Glu Ile Arg Thr Ser Gly Gly     135 140 145 gga aaa act gtc gac gtt att ttt gaa cat cct gtc gct gat tgg cat 595 Gly Lys Thr Val Asp Val Ile Phe Glu His Pro Val Ala Asp Trp His 150 155 160 165 ttg ctg ttt aac aat ttg ttg ccg agt cat ttg atc act ggc aat tcc 643 Leu Leu Phe Asn Asn Leu Leu Pro Ser His Leu Ile Thr Gly Asn Ser                 170 175 180 aca ttc cag aca gcg ttt tat gat tcc atc ccg gcc tct gcg ggg cgc 691 Thr Phe Gln Thr Ala Phe Tyr Asp Ser Ile Pro Ala Ser Ala Gly Arg             185 190 195 tac atg gtg cgt tcc att gat cgt cag cgc ggc gtg att acg ttg tcg 739 Tyr Met Val Arg Ser Ile Asp Arg Gln Arg Gly Val Ile Thr Leu Ser         200 205 210 cgc aat gat cgt ttc tgg ggt gca aat ccg gca cac gtg gaa gta ctc 787 Arg Asn Asp Arg Phe Trp Gly Ala Asn Pro Ala His Val Glu Val Leu     215 220 225 caa ttc aac acc gtt gcc tct gca tcc cgg gcg ggg gag tac ctg cgc 835 Gln Phe Asn Thr Val Ala Ser Ala Ser Arg Ala Gly Glu Tyr Leu Arg 230 235 240 245 acc ggg cag agt tcg ttt atg aat ctg tca ccg cag gaa acc ctg gtg 883 Thr Gly Gln Ser Ser Phe Met Asn Leu Ser Pro Gln Glu Thr Leu Val                 250 255 260 gac acg ttg aat ttg gtg ccg gac acg gaa gtg cgg gtg tct gac acg 931 Asp Thr Leu Asn Leu Val Pro Asp Thr Glu Val Arg Val Ser Asp Thr             265 270 275 acg cgc acg ctg gag ctg gta ttc aac gcc gaa gcg ctg gca ccg gcg 979 Thr Arg Thr Leu Glu Leu Val Phe Asn Ala Glu Ala Leu Ala Pro Ala         280 285 290 cag cgc gcc tac ctg aca tcg ctt atc gac gtc ccc ctc acc gcc aag 1027 Gln Arg Ala Tyr Leu Thr Ser Leu Ile Asp Val Pro Leu Thr Ala Lys     295 300 305 tta gct ggc ggt cgc agt gca aac ctg ggt gtg ccc caa acg gtg gag 1075 Leu Ala Gly Gly Arg Ser Ala Asn Leu Gly Val Pro Gln Thr Val Glu 310 315 320 325 gcg agc gtc gat aag caa gaa att cct gcg ttg cgc ctg gcg gcg gac 1123 Ala Ser Val Asp Lys Gln Glu Ile Pro Ala Leu Arg Leu Ala Ala Asp                 330 335 340 ccc gcc gac gat gct ggt ttg gca gct gcg cgg ggc atc gtc gat atg 1171 Pro Ala Asp Asp Ala Gly Leu Ala Ala Ala Arg Gly Ile Val Asp Met             345 350 355 ctg gct gcg gat gga atc aag gct cag gtc gtg aca acc gat ttg aat 1219 Leu Ala Ala Asp Gly Ile Lys Ala Gln Val Val Thr Thr Asp Leu Asn         360 365 370 tcg gcg att gcg ggt aat ttt gat gcg atc gtg gcg tgg acc aga act 1267 Ser Ala Ile Ala Gly Asn Phe Asp Ala Ile Val Ala Trp Thr Arg Thr     375 380 385 gcc acg gat tcg att gcg ttg gcg gac cga gtg ggt tgt ggc gtg aac 1315 Ala Thr Asp Ser Ile Ala Leu Ala Asp Arg Val Gly Cys Gly Val Asn 390 395 400 405 ttg gca aag tgg tgc gct gag gga acc acg gaa tat atc aac ggt gtt 1363 Leu Ala Lys Trp Cys Ala Glu Gly Thr Thr Glu Tyr Ile Asn Gly Val                 410 415 420 ttg gcg ggt gag att gat ttc gat cct gcg tgg gag cag cag ttt aac 1411 Leu Ala Gly Glu Ile Asp Phe Asp Pro Ala Trp Glu Gln Gln Phe Asn             425 430 435 acc gag aat cac ttg cgg gtt ccg atc ctg cgg gag act cgg gta gaa 1459 Thr Glu Asn His Leu Arg Val Pro Ile Leu Arg Glu Thr Arg Val Glu         440 445 450 gcg aaa aat aac ggt atc ctc ggg gct gcg gat ggc tgg cct ggg gga 1507 Ala Lys Asn Asn Gly Ile Leu Gly Ala Ala Asp Gly Trp Pro Gly Gly     455 460 465 att tca agt gct gca agt tgg agg aaa aac gat gtt gaa gaa 1549 Ile Ser Ser Ala Ala Ser Trp Arg Lys Asn Asp Val Glu Glu 470 475 480 tgatctgtct ggtgctcgag ttg 1572 <210> 638 <211> 483 <212> PRT <213> Corynebacterium glutamicum <400> 638 Val Ala Cys Gln Ala Asn Pro Gly Pro Ala Pro Val Glu Glu Pro Thr   1 5 10 15 Thr Ala Thr Ala Thr Thr Thr Ala Thr Glu Thr Thr Thr Val Glu Thr              20 25 30 Glu Ala Pro Lys Gln Asp Arg Glu Thr Ile Ser Ile Gly Ile Asp Pro          35 40 45 Ile Arg Asn Gly Phe Asn Pro His Leu Leu Ser Asp Asp Ser Pro Leu      50 55 60 Val Arg Asp Thr Ala Ser Leu Val Leu Pro Ser Ala Phe Glu Gly Asn  65 70 75 80 Gln Leu Asn Thr Asp Leu Leu Asp Asn Val Glu Gln Val Asp Glu Thr                  85 90 95 Thr Val Arg Tyr Thr Ile Ala Gln Glu Ala Gln Trp Ser Asp Gly Thr             100 105 110 Pro Ile Thr Gly Ser Asp Phe Glu Tyr Leu Arg Arg Ser Ile Val Ala         115 120 125 Gly Thr Gly Thr Leu Asn Asp Ser Ala Tyr Ser Ala Ile Ser Glu Ile     130 135 140 Arg Thr Ser Gly Gly Gly Lys Thr Val Asp Val Ile Phe Glu His Pro 145 150 155 160 Val Ala Asp Trp His Leu Leu Phe Asn Asn Leu Leu Pro Ser His Leu                 165 170 175 Ile Thr Gly Asn Ser Thr Phe Gln Thr Ala Phe Tyr Asp Ser Ile Pro             180 185 190 Ala Ser Ala Gly Arg Tyr Met Val Arg Ser Ile Asp Arg Gln Arg Gly         195 200 205 Val Ile Thr Leu Ser Arg Asn Asp Arg Phe Trp Gly Ala Asn Pro Ala     210 215 220 His Val Glu Val Leu Gln Phe Asn Thr Val Ala Ser Ala Ser Arg Ala 225 230 235 240 Gly Glu Tyr Leu Arg Thr Gly Gln Ser Ser Phe Met Asn Leu Ser Pro                 245 250 255 Gln Glu Thr Leu Val Asp Thr Leu Asn Leu Val Pro Asp Thr Glu Val             260 265 270 Arg Val Ser Asp Thr Thr Arg Thr Leu Glu Leu Val Phe Asn Ala Glu         275 280 285 Ala Leu Ala Pro Ala Gln Arg Ala Tyr Leu Thr Ser Leu Ile Asp Val     290 295 300 Pro Leu Thr Ala Lys Leu Ala Gly Gly Arg Ser Ala Asn Leu Gly Val 305 310 315 320 Pro Gln Thr Val Glu Ala Ser Val Asp Lys Gln Glu Ile Pro Ala Leu                 325 330 335 Arg Leu Ala Ala Asp Pro Ala Asp Asp Asp Gly Leu Ala Ala Ala Arg             340 345 350 Gly Ile Val Asp Met Leu Ala Ala Asp Gly Ile Lys Ala Gln Val Val         355 360 365 Thr Thr Asp Leu Asn Ser Ala Ile Ala Gly Asn Phe Asp Ala Ile Val     370 375 380 Ala Trp Thr Arg Thr Ala Thr Asp Ser Ile Ala Leu Ala Asp Arg Val 385 390 395 400 Gly Cys Gly Val Asn Leu Ala Lys Trp Cys Ala Glu Gly Thr Thr Glu                 405 410 415 Tyr Ile Asn Gly Val Leu Ala Gly Glu Ile Asp Phe Asp Pro Ala Trp             420 425 430 Glu Gln Gln Phe Asn Thr Glu Asn His Leu Arg Val Pro Ile Leu Arg         435 440 445 Glu Thr Arg Val Glu Ala Lys Asn Asn Gly Ile Leu Gly Ala Ala Asp     450 455 460 Gly Trp Pro Gly Gly Ile Ser Ser Ala Ala Ser Trp Arg Lys Asn Asp 465 470 475 480 Val Glu Glu <210> 639 <211> 1192 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1192) <223> RXN01382 <400> 639 aaaggatgta cctcatgagc accacgatta ctcgccgcaa tttcctccga gcaaccggaa 60 tcctcggtgt cgcagctggc atcggcgcaa cacttgctgc atg tgc acc aac aac 115                                             Met Cys Thr Asn Asn                                               1 5 acc ggc acc agc gga tcc acc tcc acc gca gct ggc acc gga act gca 163 Thr Gly Thr Ser Gly Ser Thr Ser Thr Ala Aly Gly Thr Gly Thr Ala                  10 15 20 aat gaa gaa ggc acc atc acc gca gcc atc tcc tac gaa ctg gga acc 211 Asn Glu Glu Gly Thr Ile Thr Ala Ala Ile Ser Tyr Glu Leu Gly Thr              25 30 35 aac ggc tac gac cca atg acc acc acc tcg gct ctc act gtg gca gcc 259 Asn Gly Tyr Asp Pro Met Thr Thr Thr Ser Ser Ala Leu Thr Val Ala Ala          40 45 50 aac tgg cac acc ctt gaa ggc ctc acc gaa atc gac cca gcc acc ggc 307 Asn Trp His Thr Leu Glu Gly Leu Thr Glu Ile Asp Pro Ala Thr Gly      55 60 65 gag gtc tac gca gca ctc gcc agc gca ctg cct tca gcc gat gcg acc 355 Glu Val Tyr Ala Ala Leu Ala Ser Ala Leu Pro Ser Ala Asp Ala Thr  70 75 80 85 tcc cta gac atc aag ctt cgc gac ggc gcc acc ttc cac aac ggc gac 403 Ser Leu Asp Ile Lys Leu Arg Asp Gly Ala Thr Phe His Asn Gly Asp                  90 95 100 gca gtc acc gca gac gac gta gtc ttc tct ttt gag cga gtc ctc gat 451 Ala Val Thr Ala Asp Asp Val Val Phe Ser Phe Glu Arg Val Leu Asp             105 110 115 cca gcc aac aac tcc ctt tac gca tcc ttc atc cca ttc atc aag tca 499 Pro Ala Asn Asn Ser Leu Tyr Ala Ser Phe Ile Pro Phe Ile Lys Ser         120 125 130 gtc acc aag aag gat gac acc acc gtc acc atc gac ctc gac tac gca 547 Val Thr Lys Lys Asp Asp Thr Thr Val Thr Ile Asp Leu Asp Tyr Ala     135 140 145 acc ggc atc atc agc gaa cgc ctc gca gta gta aag atc gtg cca aag 595 Thr Gly Ile Ile Ser Glu Arg Leu Ala Val Val Lys Ile Val Pro Lys 150 155 160 165 tcc gtc gtg gaa gca gac gca tcc gga ttc gac gcc aac cca atc ggc 643 Ser Val Val Glu Ala Asp Ala Ser Gly Phe Asp Ala Asn Pro Ile Gly                 170 175 180 tcc ggc cca tac aag atg acc gac aac ggt gca tcc aag gtg gtc aag 691 Ser Gly Pro Tyr Lys Met Thr Asp Asn Gly Ala Ser Lys Val Val Lys             185 190 195 ttc gag cgc aac gac gac tac aac ggc cca cgc cca gca cgt gcc gcc 739 Phe Glu Arg Asn Asp Asp Tyr Asn Gly Pro Arg Pro Ala Arg Ala Ala         200 205 210 aag atg gaa tgg cag atc atc ccc gac gcc tcc acc cgc acc aac tcc 787 Lys Met Glu Trp Gln Ile Ile Pro Asp Ala Ser Thr Arg Thr Asn Ser     215 220 225 ctt cag tcc ggc agc acc atg gcc atc gac tcc gtt cca tac ctg tcg 835 Leu Gln Ser Gly Ser Thr Met Ala Ile Asp Ser Val Pro Tyr Leu Ser 230 235 240 245 atc cca cag ctt gaa gcc acc agc acc gta gaa tcc gtc caa gga ttc 883 Ile Pro Gln Leu Glu Ala Thr Ser Thr Val Glu Ser Val Gln Gly Phe                 250 255 260 ggc ctc ctg ttc gcc atg ttc agc tgc tcc gaa ggc aac ccc ttc aac 931 Gly Leu Leu Phe Ala Met Phe Ser Cys Ser Glu Gly Asn Pro Phe Asn             265 270 275 gac gtc cgc aac cgc cag gca ttc ctc tac gca ctg gac atg gac aag 979 Asp Val Arg Asn Arg Gln Ala Phe Leu Tyr Ala Leu Asp Met Asp Lys         280 285 290 atc gtt aag acc ggc atg tcc gac cag gca acc cca gcc acc tcc ttc 1027 Ile Val Lys Thr Gly Met Ser Asp Gln Ala Thr Pro Ala Thr Ser Phe     295 300 305 gtg cag aag gaa cac ccc aac tac aac cag gca tcc acg gtc tac tcc 1075 Val Gln Lys Glu His Pro Asn Tyr Asn Gln Ala Ser Thr Val Tyr Ser 310 315 320 325 ctc gac gcc gac aaa gcc aag gcg ctg ttc gct gaa acc ggc ctt acc 1123 Leu Asp Ala Asp Lys Ala Lys Ala Leu Phe Ala Glu Thr Gly Leu Thr                 330 335 340 agc ctc aac ctc ctg tgc acc gac cac gac tgg gtc aag aac tgc acc 1171 Ser Leu Asn Leu Leu Cys Thr Asp His Asp Trp Val Lys Asn Cys Thr             345 350 355 cca ctg atc cag gaa tcc ctc 1192 Pro Leu Ile Gln Glu Ser Leu         360 <210> 640 <211> 364 <212> PRT <213> Corynebacterium glutamicum <400> 640 Met Cys Thr Asn Asn Thr Gly Thr Ser Gly Ser Thr Ser Thr Ala Ala   1 5 10 15 Gly Thr Gly Thr Ala Asn Glu Glu Gly Thr Ile Thr Ala Ala Ile Ser              20 25 30 Tyr Glu Leu Gly Thr Asn Gly Tyr Asp Pro Met Thr Thr Thr Ser Ala          35 40 45 Leu Thr Val Ala Ala Asn Trp His Thr Leu Glu Gly Leu Thr Glu Ile      50 55 60 Asp Pro Ala Thr Gly Glu Val Tyr Ala Ala Leu Ala Ser Ala Leu Pro  65 70 75 80 Ser Ala Asp Ala Thr Ser Leu Asp Ile Lys Leu Arg Asp Gly Ala Thr                  85 90 95 Phe His Asn Gly Asp Ala Val Thr Ala Asp Asp Val Val Phe Ser Phe             100 105 110 Glu Arg Val Leu Asp Pro Ala Asn Asn Ser Leu Tyr Ala Ser Phe Ile         115 120 125 Pro Phe Ile Lys Ser Val Thr Lys Lys Asp Asp Thr Thr Val Thr Ile     130 135 140 Asp Leu Asp Tyr Ala Thr Gly Ile Ile Ser Glu Arg Leu Ala Val Val 145 150 155 160 Lys Ile Val Pro Lys Ser Val Val Glu Ala Asp Ala Ser Gly Phe Asp                 165 170 175 Ala Asn Pro Ile Gly Ser Gly Pro Tyr Lys Met Thr Asp Asn Gly Ala             180 185 190 Ser Lys Val Val Lys Phe Glu Arg Asn Asp Asp Tyr Asn Gly Pro Arg         195 200 205 Pro Ala Arg Ala Ala Lys Met Glu Trp Gln Ile Ile Pro Asp Ala Ser     210 215 220 Thr Arg Thr Asn Ser Leu Gln Ser Gly Ser Thr Met Ala Ile Asp Ser 225 230 235 240 Val Pro Tyr Leu Ser Ile Pro Gln Leu Glu Ala Thr Ser Thr Val Glu                 245 250 255 Ser Val Gln Gly Phe Gly Leu Leu Phe Ala Met Phe Ser Cys Ser Glu             260 265 270 Gly Asn Pro Phe Asn Asp Val Arg Asn Arg Gln Ala Phe Leu Tyr Ala         275 280 285 Leu Asp Met Asp Lys Ile Val Lys Thr Gly Met Ser Asp Gln Ala Thr     290 295 300 Pro Ala Thr Ser Phe Val Gln Lys Glu His Pro Asn Tyr Asn Gln Ala 305 310 315 320 Ser Thr Val Tyr Ser Leu Asp Ala Asp Lys Ala Lys Ala Leu Phe Ala                 325 330 335 Glu Thr Gly Leu Thr Ser Leu Asn Leu Leu Cys Thr Asp His Asp Trp             340 345 350 Val Lys Asn Cys Thr Pro Leu Ile Gln Glu Ser Leu         355 360 <210> 641 <211> 1062 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (1) .. (1062) <223> FRXA01382 <400> 641 tcc acc tcc acc gca gct ggc acc gga act gca aat gaa gaa ggc acc 48 Ser Thr Ser Thr Ala Ala Gly Thr Gly Thr Ala Asn Glu Glu Gly Thr   1 5 10 15 atc acc gca gcc atc tcc tac gaa ctg gga acc aac ggc tac gac cca 96 Ile Thr Ala Ala Ile Ser Tyr Glu Leu Gly Thr Asn Gly Tyr Asp Pro              20 25 30 atg acc acc acc tcg gct ctc act gtg gca gcc aac tgg cac acc ctt 144 Met Thr Thr Thr Ser Ser Ala Leu Thr Val Ala Ala Asn Trp His Thr Leu          35 40 45 gaa ggc ctc acc gaa atc gac cca gcc acc ggc gag gtc tac gca gca 192 Glu Gly Leu Thr Glu Ile Asp Pro Ala Thr Gly Glu Val Tyr Ala Ala      50 55 60 ctc gcc agc gca ctg cct tca gcc gat gcg acc tcc cta gac atc aag 240 Leu Ala Ser Ala Leu Pro Ser Ala Asp Ala Thr Ser Leu Asp Ile Lys  65 70 75 80 ctt cgc gac ggc gcc acc ttc cac aac ggc gac gca gtc acc gca gac 288 Leu Arg Asp Gly Ala Thr Phe His Asn Gly Asp Ala Val Thr Ala Asp                  85 90 95 gac gta gtc ttc tct ttt gag cga gtc ctc gat cca gcc aac aac tcc 336 Asp Val Val Phe Ser Phe Glu Arg Val Leu Asp Pro Ala Asn Asn Ser             100 105 110 ctt tac gca tcc ttc atc cca ttc atc aag tca gtc acc aag aag gat 384 Leu Tyr Ala Ser Phe Ile Pro Phe Ile Lys Ser Val Thr Lys Lys Asp         115 120 125 gac acc acc gtc acc atc gac ctc gac tac gca acc ggc atc atc agc 432 Asp Thr Thr Val Thr Ile Asp Leu Asp Tyr Ala Thr Gly Ile Ile Ser     130 135 140 gaa cgc ctc gca gta gta aag atc gtg cca aag tcc gtc gtg gaa gca 480 Glu Arg Leu Ala Val Val Lys Ile Val Pro Lys Ser Val Val Glu Ala 145 150 155 160 gac gca tcc gga ttc gac gcc aac cca atc ggc tcc ggc cca tac aag 528 Asp Ala Ser Gly Phe Asp Ala Asn Pro Ile Gly Ser Gly Pro Tyr Lys                 165 170 175 atg acc gac aac ggt gca tcc aag gtg gtc aag ttc gag cgc aac gac 576 Met Thr Asp Asn Gly Ala Ser Lys Val Val Lys Phe Glu Arg Asn Asp             180 185 190 gac tac aac ggc cca cgc cca gca cgt gcc gcc aag atg gaa tgg cag 624 Asp Tyr Asn Gly Pro Arg Pro Ala Arg Ala Ala Lys Met Glu Trp Gln         195 200 205 atc atc ccc gac gcc tcc acc cgc acc aac tcc ctt cag tcc ggc agc 672 Ile Ile Pro Asp Ala Ser Thr Arg Thr Asn Ser Leu Gln Ser Gly Ser     210 215 220 acc atg gcc atc gac tcc gtt cca tac ctg tcg atc cca cag ctt gaa 720 Thr Met Ala Ile Asp Ser Val Pro Tyr Leu Ser Ile Pro Gln Leu Glu 225 230 235 240 gcc acc agc acc gta gaa tcc gtc caa gga ttc ggc ctc ctg ttc gcc 768 Ala Thr Ser Thr Val Glu Ser Val Gln Gly Phe Gly Leu Leu Phe Ala                 245 250 255 atg ttc agc tgc tcc gaa ggc aac ccc ttc aac gac gtc cgc aac cgc 816 Met Phe Ser Cys Ser Glu Gly Asn Pro Phe Asn Asp Val Arg Asn Arg             260 265 270 cag gca ttc ctc tac gca ctg gac atg gac aag atc gtt aag acc ggc 864 Gln Ala Phe Leu Tyr Ala Leu Asp Met Asp Lys Ile Val Lys Thr Gly         275 280 285 atg tcc gac cag gca acc cca gcc acc tcc ttc gtg cag aag gaa cac 912 Met Ser Asp Gln Ala Thr Pro Ala Thr Ser Phe Val Gln Lys Glu His     290 295 300 ccc aac tac aac cag gca tcc acg gtc tac tcc ctc gac gcc gac aaa 960 Pro Asn Tyr Asn Gln Ala Ser Thr Val Tyr Ser Leu Asp Ala Asp Lys 305 310 315 320 gcc aag gcg ctg ttc gct gaa acc ggc ctt acc agc ctc aac ctc ctg 1008 Ala Lys Ala Leu Phe Ala Glu Thr Gly Leu Thr Ser Leu Asn Leu Leu                 325 330 335 tgc acc gac cac gac tgg gtc aag aac tgc acc cca ctg atc cag gaa 1056 Cys Thr Asp His Asp Trp Val Lys Asn Cys Thr Pro Leu Ile Gln Glu             340 345 350 tcc ctc 1062 Ser leu <210> 642 <211> 354 <212> PRT <213> Corynebacterium glutamicum <400> 642 Ser Thr Ser Thr Ala Ala Gly Thr Gly Thr Ala Asn Glu Glu Gly Thr   1 5 10 15 Ile Thr Ala Ala Ile Ser Tyr Glu Leu Gly Thr Asn Gly Tyr Asp Pro              20 25 30 Met Thr Thr Thr Ser Ser Ala Leu Thr Val Ala Ala Asn Trp His Thr Leu          35 40 45 Glu Gly Leu Thr Glu Ile Asp Pro Ala Thr Gly Glu Val Tyr Ala Ala      50 55 60 Leu Ala Ser Ala Leu Pro Ser Ala Asp Ala Thr Ser Leu Asp Ile Lys  65 70 75 80 Leu Arg Asp Gly Ala Thr Phe His Asn Gly Asp Ala Val Thr Ala Asp                  85 90 95 Asp Val Val Phe Ser Phe Glu Arg Val Leu Asp Pro Ala Asn Asn Ser             100 105 110 Leu Tyr Ala Ser Phe Ile Pro Phe Ile Lys Ser Val Thr Lys Lys Asp         115 120 125 Asp Thr Thr Val Thr Ile Asp Leu Asp Tyr Ala Thr Gly Ile Ile Ser     130 135 140 Glu Arg Leu Ala Val Val Lys Ile Val Pro Lys Ser Val Val Glu Ala 145 150 155 160 Asp Ala Ser Gly Phe Asp Ala Asn Pro Ile Gly Ser Gly Pro Tyr Lys                 165 170 175 Met Thr Asp Asn Gly Ala Ser Lys Val Val Lys Phe Glu Arg Asn Asp             180 185 190 Asp Tyr Asn Gly Pro Arg Pro Ala Arg Ala Ala Lys Met Glu Trp Gln         195 200 205 Ile Ile Pro Asp Ala Ser Thr Arg Thr Asn Ser Leu Gln Ser Gly Ser     210 215 220 Thr Met Ala Ile Asp Ser Val Pro Tyr Leu Ser Ile Pro Gln Leu Glu 225 230 235 240 Ala Thr Ser Thr Val Glu Ser Val Gln Gly Phe Gly Leu Leu Phe Ala                 245 250 255 Met Phe Ser Cys Ser Glu Gly Asn Pro Phe Asn Asp Val Arg Asn Arg             260 265 270 Gln Ala Phe Leu Tyr Ala Leu Asp Met Asp Lys Ile Val Lys Thr Gly         275 280 285 Met Ser Asp Gln Ala Thr Pro Ala Thr Ser Phe Val Gln Lys Glu His     290 295 300 Pro Asn Tyr Asn Gln Ala Ser Thr Val Tyr Ser Leu Asp Ala Asp Lys 305 310 315 320 Ala Lys Ala Leu Phe Ala Glu Thr Gly Leu Thr Ser Leu Asn Leu Leu                 325 330 335 Cys Thr Asp His Asp Trp Val Lys Asn Cys Thr Pro Leu Ile Gln Glu             340 345 350 Ser leu <210> 643 <211> 335 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (312) <223> RXA02659 <400> 643 ttc ggc aac gac cca gac ctc ctc atg cgc tgg tgg tac gcc ggc gac 48 Phe Gly Asn Asp Pro Asp Leu Leu Met Arg Trp Trp Tyr Ala Gly Asp   1 5 10 15 gtc tgg acc gac tcc cgc atg cac tgg aag ggc agc gaa tcc tac gac 96 Val Trp Thr Asp Ser Arg Met His Trp Lys Gly Ser Glu Ser Tyr Asp              20 25 30 cag gta caa aac ctc ctg gaa gaa ggc atc cgc gct acc gac aag gca 144 Gln Val Gln Asn Leu Leu Glu Glu Gly Ile Arg Ala Thr Asp Lys Ala          35 40 45 gaa cag caa gac atc tgg aac cgc acc ttc gat gtc atc tcc gac aat 192 Glu Gln Gln Asp Ile Trp Asn Arg Thr Phe Asp Val Ile Ser Asp Asn      50 55 60 gtt ccc ctc tac ccg ctg ttc cac cgc aag gtc cca acc gca tgg aac 240 Val Pro Leu Tyr Pro Leu Phe His Arg Lys Val Pro Thr Ala Trp Asn  65 70 75 80 tcc aac gcc ctc gtc gac ttc aag cca atc tca ctc acc ggc ttg aac 288 Ser Asn Ala Leu Val Asp Phe Lys Pro Ile Ser Leu Thr Gly Leu Asn                  85 90 95 ttc tca ggt gtt gca act act gaa taacaacccc agtggctttc aaa 335 Phe Ser Gly Val Ala Thr Thr Glu             100 <210> 644 <211> 104 <212> PRT <213> Corynebacterium glutamicum <400> 644 Phe Gly Asn Asp Pro Asp Leu Leu Met Arg Trp Trp Tyr Ala Gly Asp   1 5 10 15 Val Trp Thr Asp Ser Arg Met His Trp Lys Gly Ser Glu Ser Tyr Asp              20 25 30 Gln Val Gln Asn Leu Leu Glu Glu Gly Ile Arg Ala Thr Asp Lys Ala          35 40 45 Glu Gln Gln Asp Ile Trp Asn Arg Thr Phe Asp Val Ile Ser Asp Asn      50 55 60 Val Pro Leu Tyr Pro Leu Phe His Arg Lys Val Pro Thr Ala Trp Asn  65 70 75 80 Ser Asn Ala Leu Val Asp Phe Lys Pro Ile Ser Leu Thr Gly Leu Asn                  85 90 95 Phe Ser Gly Val Ala Thr Thr Glu             100 <210> 645 <211> 933 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (910) <223> RXN02933 <400> 645 tgatctgctg tatcaggtgg ttgatccaag agtcggtgct gttggggttg ctagcactaa 60 ggttccaggg agcgtggctt aagtgacaac gatcaaaaac atg ccc ctt tca ggg 115                                             Met Pro Leu Ser Gly                                               1 5 aaa atc ggc ggc ttc atc gtt gcc gtt gta ttt gtt ctt gct gcg ctg 163 Lys Ile Gly Gly Phe Ile Val Ala Val Val Phe Val Leu Ala Ala Leu                  10 15 20 tct ttc att tgg act ccg ttt gat cca gtt caa gct ttc cca cag gag 211 Ser Phe Ile Trp Thr Pro Phe Asp Pro Val Gln Ala Phe Pro Gln Glu              25 30 35 cgc ctt gag gga agt tct ttg agg cac ctg ttg gga acg gat cgt tat 259 Arg Leu Glu Gly Ser Ser Leu Arg His Leu Leu Gly Thr Asp Arg Tyr          40 45 50 ggt cgc gat gtt tta tcc cag atc atg gtt ggt tcc cgc gtc acg ttg 307 Gly Arg Asp Val Leu Ser Gln Ile Met Val Gly Ser Arg Val Thr Leu      55 60 65 ttg gtg ggc atc att gcg gtg gcg atc gca gca tta atc ggc acg cca 355 Leu Val Gly Ile Ile Ala Val Ala Ile Ala Ala Leu Ile Gly Thr Pro  70 75 80 85 ctg ggt att gct gcg gga atg cgc cgt ggc atg gtg gaa acc ttt gtc 403 Leu Gly Ile Ala Ala Gly Met Arg Arg Gly Met Val Glu Thr Phe Val                  90 95 100 atg cgt ggt gcc gat tta atg ttg gcg ttc cca gca ctg ttg ttg gcg 451 Met Arg Gly Ala Asp Leu Met Leu Ala Phe Pro Ala Leu Leu Leu Ala             105 110 115 att att tcc ggc gcc gtt ttc ggc gcc tcc acg tgg tcc gcg atg gtc 499 Ile Ile Ser Gly Ala Val Phe Gly Ala Ser Thr Trp Ser Ala Met Val         120 125 130 gcg atc ggc atc gca ggc atc cct agt ttt gcc cgc gtg gct cgt gca 547 Ala Ile Gly Ile Ala Gly Ile Pro Ser Phe Ala Arg Val Ala Arg Ala     135 140 145 ggc aca ttg cag gtg acc agt cag gat ttc atc gca gct gct cgg cta 595 Gly Thr Leu Gln Val Thr Ser Gln Asp Phe Ile Ala Ala Ala Arg Leu 150 155 160 165 tca aaa gta agt tcc gcc cgg atc gcg ctt cgc cat att ttg ccc aac 643 Ser Lys Val Ser Ser Ala Arg Ile Ala Leu Arg His Ile Leu Pro Asn                 170 175 180 atc acc agc atg ttg atc gtt cag gca tca gta gct ttt gcc ctg gcg 691 Ile Thr Ser Met Leu Ile Val Gln Ala Ser Val Ala Phe Ala Leu Ala             185 190 195 atc ctg gcg gaa gcc gca ttg agt ttc ctc ggt ttg ggc acc act ccc 739 Ile Leu Ala Glu Ala Ala Leu Ser Phe Leu Gly Leu Gly Thr Thr Pro         200 205 210 ccg gat ccc agc tgg ggt cgc atg ttg caa acc gct caa gca tcc atc 787 Pro Asp Pro Ser Trp Gly Arg Met Leu Gln Thr Ala Gln Ala Ser Ile     215 220 225 ggc gtc acc ccc atg ttg gcg gtg tgg ccc ggt gct gcg atc gct ttg 835 Gly Val Thr Pro Met Leu Ala Val Trp Pro Gly Ala Ala Ile Ala Leu 230 235 240 245 acg gtc ctt ggt ttt aat ctt ttc ggt gat ggt tta cgc gat gcc atc 883 Thr Val Leu Gly Phe Asn Leu Phe Gly Asp Gly Leu Arg Asp Ala Ile                 250 255 260 gat cca aag cgg gag gtc ggc cgt gct taaagtttct gatttaacgg 930 Asp Pro Lys Arg Glu Val Gly Arg Ala             265 270 ttg 933 <210> 646 <211> 270 <212> PRT <213> Corynebacterium glutamicum <400> 646 Met Pro Leu Ser Gly Lys Ile Gly Gly Phe Ile Val Ala Val Val Phe   1 5 10 15 Val Leu Ala Ala Leu Ser Phe Ile Trp Thr Pro Phe Asp Pro Val Gln              20 25 30 Ala Phe Pro Gln Glu Arg Leu Glu Gly Ser Ser Leu Arg His Leu Leu          35 40 45 Gly Thr Asp Arg Tyr Gly Arg Asp Val Leu Ser Gln Ile Met Val Gly      50 55 60 Ser Arg Val Thr Leu Leu Val Gly Ile Ile Ala Val Ala Ile Ala Ala  65 70 75 80 Leu Ile Gly Thr Pro Leu Gly Ile Ala Ala Gly Met Arg Arg Gly Met                  85 90 95 Val Glu Thr Phe Val Met Arg Gly Ala Asp Leu Met Leu Ala Phe Pro             100 105 110 Ala Leu Leu Leu Ala Ile Ile Ser Gly Ala Val Phe Gly Ala Ser Thr         115 120 125 Trp Ser Ala Met Val Ala Ile Gly Ile Ala Gly Ile Pro Ser Phe Ala     130 135 140 Arg Val Ala Arg Ala Gly Thr Leu Gln Val Thr Ser Gln Asp Phe Ile 145 150 155 160 Ala Ala Ala Arg Leu Ser Lys Val Ser Ser Ala Arg Ile Ala Leu Arg                 165 170 175 His Ile Leu Pro Asn Ile Thr Ser Met Leu Ile Val Gln Ala Ser Val             180 185 190 Ala Phe Ala Leu Ala Ile Leu Ala Glu Ala Ala Leu Ser Phe Leu Gly         195 200 205 Leu Gly Thr Thr Pro Pro Asp Pro Ser Trp Gly Arg Met Leu Gln Thr     210 215 220 Ala Gln Ala Ser Ile Gly Val Thr Pro Met Leu Ala Val Trp Pro Gly 225 230 235 240 Ala Ala Ile Ala Leu Thr Val Leu Gly Phe Asn Leu Phe Gly Asp Gly                 245 250 255 Leu Arg Asp Ala Ile Asp Pro Lys Arg Glu Val Gly Arg Ala             260 265 270 <210> 647 <211> 715 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (715) <223> RXN02991 <400> 647 ttgtcgtgtt cgcgatcttc gccgttggct tcatgattct gaccctgcct atgggccttg 60 gcttgggcaa actctctgag cgtttggcgg tgaagaagta atg gct aat aca gtt 115                                             Met ala asn thr val                                               1 5 cgc gca aca gtc ctc tac gat gct cct gga cca aag ggc cgt cga ttc 163 Arg Ala Thr Val Leu Tyr Asp Ala Pro Gly Pro Lys Gly Arg Arg Phe                  10 15 20 aac ctc ata atc acc att ctc acg gtg gtt ctg gga ttg gcg ctc ctc 211 Asn Leu Ile Ile Thr Ile Leu Thr Val Val Leu Gly Leu Ala Leu Leu              25 30 35 ttc tgg att ggc tcc atg ctt tca ggc aac ggc caa ctc gat gcc aac 259 Phe Trp Ile Gly Ser Met Leu Ser Gly Asn Gly Gln Leu Asp Ala Asn          40 45 50 aaa tgg act ccg ttc atc aat tcc caa acc tgg acc acc tac att ctt 307 Lys Trp Thr Pro Phe Ile Asn Ser Gln Thr Trp Thr Thr Tyr Ile Leu      55 60 65 cct ggt ttg tgg ggc acg ctg aaa tct gcc gtg ttc tcg gtg atc ttg 355 Pro Gly Leu Trp Gly Thr Leu Lys Ser Ala Val Phe Ser Val Ile Leu  70 75 80 85 gct ctg gtc atg ggt acc gca ctg ggt ctt ggc cgt atc tct gaa atc 403 Ala Leu Val Met Gly Thr Ala Leu Gly Leu Gly Arg Ile Ser Glu Ile                  90 95 100 agg att ctc cgc tgg ttc tgc gcc gtc atc atc gag act ttc cga gcc 451 Arg Ile Leu Arg Trp Phe Cys Ala Val Ile Ile Glu Thr Phe Arg Ala             105 110 115 att ccg gtt ctg atc ctc atg att ttc gcc tac cag atg ttc gcc cag 499 Ile Pro Val Leu Ile Leu Met Ile Phe Ala Tyr Gln Met Phe Ala Gln         120 125 130 tac aac atc gtg ccg tcg agc cag ctc gcg ttc gcc gcc gtg gta ttc 547 Tyr Asn Ile Val Pro Ser Ser Gln Leu Ala Phe Ala Ala Val Val Phe     135 140 145 ggt ctg acc atg tac aac ggt tct gtg atc gca gag att ctg cgt tct 595 Gly Leu Thr Met Tyr Asn Gly Ser Val Ile Ala Glu Ile Leu Arg Ser 150 155 160 165 ggt atc gct tcc ctg cct aag ggg cag aag gaa gca gcg att gcg ttg 643 Gly Ile Ala Ser Leu Pro Lys Gly Gln Lys Glu Ala Ala Ile Ala Leu                 170 175 180 ggt atg tct tct agg caa acc acc tgg tca atc ttg ttg cct cag gcc 691 Gly Met Ser Ser Arg Gln Thr Thr Trp Ser Ile Leu Leu Pro Gln Ala             185 190 195 gtg gct gca atg ctc cca gcg ttg 715 Val Ala Ala Met Leu Pro Ala Leu         200 205 <210> 648 <211> 205 <212> PRT <213> Corynebacterium glutamicum <400> 648 Met Ala Asn Thr Val Arg Ala Thr Val Leu Tyr Asp Ala Pro Gly Pro   1 5 10 15 Lys Gly Arg Arg Phe Asn Leu Ile Ile Thr Ile Leu Thr Val Val Leu              20 25 30 Gly Leu Ala Leu Leu Phe Trp Ile Gly Ser Met Leu Ser Gly Asn Gly          35 40 45 Gln Leu Asp Ala Asn Lys Trp Thr Pro Phe Ile Asn Ser Gln Thr Trp      50 55 60 Thr Thr Tyr Ile Leu Pro Gly Leu Trp Gly Thr Leu Lys Ser Ala Val  65 70 75 80 Phe Ser Val Ile Leu Ala Leu Val Met Gly Thr Ala Leu Gly Leu Gly                  85 90 95 Arg Ile Ser Glu Ile Arg Ile Leu Arg Trp Phe Cys Ala Val Ile Ile             100 105 110 Glu Thr Phe Arg Ala Ile Pro Val Leu Ile Leu Met Ile Phe Ala Tyr         115 120 125 Gln Met Phe Ala Gln Tyr Asn Ile Val Pro Ser Ser Gln Leu Ala Phe     130 135 140 Ala Ala Val Val Phe Gly Leu Thr Met Tyr Asn Gly Ser Val Ile Ala 145 150 155 160 Glu Ile Leu Arg Ser Gly Ile Ala Ser Leu Pro Lys Gly Gln Lys Glu                 165 170 175 Ala Ala Ile Ala Leu Gly Met Ser Ser Arg Gln Thr Thr Trp Ser Ile             180 185 190 Leu Leu Pro Gln Ala Val Ala Ala Met Leu Pro Ala Leu         195 200 205 <210> 649 <211> 245 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) .. (222) <223> RXN02992 <400> 649 atc gtc cct ttg ggc aac aca ctg atc gca ctg act aag aac acc acc 48 Ile Val Pro Leu Gly Asn Thr Leu Ile Ala Leu Thr Lys Asn Thr Thr   1 5 10 15 atc gcc tct gtc att gga gtt ggc gaa gcc tcc ctg ctg atg aaa gcc 96 Ile Ala Ser Val Ile Gly Val Gly Glu Ala Ser Leu Leu Met Lys Ala              20 25 30 acc atc gaa aat cac gcc aac atg cta ttt gtc gtg ttc gcg atc ttc 144 Thr Ile Glu Asn His Ala Asn Met Leu Phe Val Val Phe Ala Ile Phe          35 40 45 gcc gtt ggc ttc atg att ctg acc ctg cct atg ggc ctt ggc ttg ggc 192 Ala Val Gly Phe Met Ile Leu Thr Leu Pro Met Gly Leu Gly Leu Gly      50 55 60 aaa ctc tct gag cgt ttg gcg gtg aag aag taatggctaa tacagttcgc 242 Lys Leu Ser Glu Arg Leu Ala Val Lys Lys  65 70 gca 245 <210> 650 <211> 74 <212> PRT <213> Corynebacterium glutamicum <400> 650 Ile Val Pro Leu Gly Asn Thr Leu Ile Ala Leu Thr Lys Asn Thr Thr   1 5 10 15 Ile Ala Ser Val Ile Gly Val Gly Glu Ala Ser Leu Leu Met Lys Ala              20 25 30 Thr Ile Glu Asn His Ala Asn Met Leu Phe Val Val Phe Ala Ile Phe          35 40 45 Ala Val Gly Phe Met Ile Leu Thr Leu Pro Met Gly Leu Gly Leu Gly      50 55 60 Lys Leu Ser Glu Arg Leu Ala Val Lys Lys  65 70 <210> 651 <211> 792 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (769) <223> RXN02996 <400> 651 tcctgccaca gaatctgcct gctgctccat taactaaaaa ttgcaggcta gaatagaggg 60 tcgattagga gtcgatgaaa aagtcggcgc caacgaggag atg aac aac aac gtg 115                                             Met Asn Asn Asn Val                                               1 5 agt gat caa aag cta agt ggt aaa gag ctt gcg gca cta gag aaa caa 163 Ser Asp Gln Lys Leu Ser Gly Lys Glu Leu Ala Ala Leu Glu Lys Gln                  10 15 20 gcc gca aaa act ctc gaa ctt ggt gat aag aag tgg tat ctc atc gcg 211 Ala Ala Lys Thr Leu Glu Leu Gly Asp Lys Lys Trp Tyr Leu Ile Ala              25 30 35 gga gtc gtg ctt ttc gcc atc gca ctc gtc ctc cca cat atc cgt gga 259 Gly Val Val Leu Phe Ala Ile Ala Leu Val Leu Pro His Ile Arg Gly          40 45 50 gtg atg ggc tgg cag gtt ctg acg ctg tcg aat gtc gcg gag gat gcc 307 Val Met Gly Trp Gln Val Leu Thr Leu Ser Asn Val Ala Glu Asp Ala      55 60 65 ggc att acc ctt ggt gag tac ggt ttc tac tgg ttg ggc acc atc ggt 355 Gly Ile Thr Leu Gly Glu Tyr Gly Phe Tyr Trp Leu Gly Thr Ile Gly  70 75 80 85 gta ttc ctg ctt tct ttg ggc act gtc gtg ttt aag cgc acg tgg atg 403 Val Phe Leu Leu Ser Leu Gly Thr Val Val Phe Lys Arg Thr Trp Met                  90 95 100 gcg tgg att tca tgg att ttc tcc tgc gtc act ctt gtg ttc gct gtg 451 Ala Trp Ile Ser Trp Ile Phe Ser Cys Val Thr Leu Val Phe Ala Val             105 110 115 ttt gcc atc tgg atg cgc caa aca acc acc agc acc caa gtg aat ttc 499 Phe Ala Ile Trp Met Arg Gln Thr Thr Thr Ser Ser Thr Gln Val Asn Phe         120 125 130 gtc aac att ggc atg atg ctt gct gtg att gca gcg atc ctt gct gtg 547 Val Asn Ile Gly Met Met Leu Ala Val Ile Ala Ala Ile Leu Ala Val     135 140 145 tgg ggt cta tct tcg gtg att ttg gcc cgc agt gat cgc caa atg gag 595 Trp Gly Leu Ser Ser Val Ile Leu Ala Arg Ser Asp Arg Gln Met Glu 150 155 160 165 atc gct gaa atg cgc gcc gag aac cca gac ctt gat ggt gtt gca gct 643 Ile Ala Glu Met Arg Ala Glu Asn Pro Asp Leu Asp Gly Val Ala Ala                 170 175 180 acc cag cgc gca ctt ctt gag cag cag caa agc aac cca gaa gat aat 691 Thr Gln Arg Ala Leu Leu Glu Gln Gln Gln Ser Asn Pro Glu Asp Asn             185 190 195 cct ttg ctt gtc gac gat cgt cgc gcc cgc atc gcc cgc cgc cgc gag 739 Pro Leu Leu Val Asp Asp Arg Arg Ala Arg Ile Ala Arg Arg Arg Glu         200 205 210 cgt gaa cag gat gca caa ggg gag cag gct taagttctag ttcaagcggt 789 Arg Glu Gln Asp Ala Gln Gly Glu Gln Ala     215 220 tga 792 <210> 652 <211> 223 <212> PRT <213> Corynebacterium glutamicum <400> 652 Met Asn Asn Asn Val Ser Asp Gln Lys Leu Ser Gly Lys Glu Leu Ala   1 5 10 15 Ala Leu Glu Lys Gln Ala Ala Lys Thr Leu Glu Leu Gly Asp Lys Lys              20 25 30 Trp Tyr Leu Ile Ala Gly Val Val Leu Phe Ala Ile Ala Leu Val Leu          35 40 45 Pro His Ile Arg Gly Val Met Gly Trp Gln Val Leu Thr Leu Ser Asn      50 55 60 Val Ala Glu Asp Ala Gly Ile Thr Leu Gly Glu Tyr Gly Phe Tyr Trp  65 70 75 80 Leu Gly Thr Ile Gly Val Phe Leu Leu Ser Leu Gly Thr Val Val Phe                  85 90 95 Lys Arg Thr Trp Met Ala Trp Ile Ser Trp Ile Phe Ser Cys Val Thr             100 105 110 Leu Val Phe Ala Val Phe Ala Ile Trp Met Arg Gln Thr Thr Thr Ser         115 120 125 Thr Gln Val Asn Phe Val Asn Ile Gly Met Met Leu Ala Val Ile Ala     130 135 140 Ala Ile Leu Ala Val Trp Gly Leu Ser Ser Val Ile Leu Ala Arg Ser 145 150 155 160 Asp Arg Gln Met Glu Ile Ala Glu Met Arg Ala Glu Asn Pro Asp Leu                 165 170 175 Asp Gly Val Ala Ala Thr Gln Arg Ala Leu Leu Glu Gln Gln Gln Ser             180 185 190 Asn Pro Glu Asp Asn Pro Leu Leu Val Asp Asp Arg Arg Ala Arg Ile         195 200 205 Ala Arg Arg Arg Glu Arg Glu Gln Asp Ala Gln Gly Glu Gln Ala     210 215 220 <210> 653 <211> 1017 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (994) <223> RXN03126 <400> 653 tcttggacaa cattacccca cacacgggac actcaaacgt gcatgaattc acctgtcgtc 60 gatacccaaa aatcactcca ccaccactag ggtgtcttat gtg cag gaa caa tcg 115                                             Val Gln Glu Gln Ser                                               1 5 aag cag aaa gac ctc cag gct gat atc gcc aga atc act gcc gtg aaa 163 Lys Gln Lys Asp Leu Gln Ala Asp Ile Ala Arg Ile Thr Ala Val Lys                  10 15 20 tcg gac aca gtt ccg aat tcc cag tca atg acc ttt ggc gct gcc tgg 211 Ser Asp Thr Val Pro Asn Ser Gln Ser Met Thr Phe Gly Ala Ala Trp              25 30 35 aac gat atc gtc cgc gga ttc aag caa cat gag ttg tgg ctg caa ctc 259 Asn Asp Ile Val Arg Gly Phe Lys Gln His Glu Leu Trp Leu Gln Leu          40 45 50 ggc tgg caa gac att aag caa cgc tac cgg cga tcc gtc ctt ggg ccc 307 Gly Trp Gln Asp Ile Lys Gln Arg Tyr Arg Arg Ser Val Leu Gly Pro      55 60 65 ctg tgg atc acc atc gcc acc ggt gtc atg gcg ctc gcc ctc ggc ttg 355 Leu Trp Ile Thr Ile Ala Thr Gly Val Met Ala Leu Ala Leu Gly Leu  70 75 80 85 ctg tac tcc gtg ctg ttc aaa atc ccc atc gcg gaa ttt ctg ccc cac 403 Leu Tyr Ser Val Leu Phe Lys Ile Pro Ile Ala Glu Phe Leu Pro His                  90 95 100 gtc acc gtc ggc ctg atc att tgg aac ttc atc tcc gga tgc atc aaa 451 Val Thr Val Gly Leu Ile Ile Trp Asn Phe Ile Ser Gly Cys Ile Lys             105 110 115 gaa ggc tcc gac atc ttc ata gat aac gag gga ctc atc aaa cag ctc 499 Glu Gly Ser Asp Ile Phe Ile Asp Asn Glu Gly Leu Ile Lys Gln Leu         120 125 130 ccc tcg gcg ctg tcc gtc cac gtg tac aga ctc gtg tgg aaa caa gcc 547 Pro Ser Ala Leu Ser Val His Val Tyr Arg Leu Val Trp Lys Gln Ala     135 140 145 ctc ttc ctc gcc cac aac ctg gtc atc tgg gtc att ctc atg atg atc 595 Leu Phe Leu Ala His Asn Leu Val Ile Trp Val Ile Leu Met Met Ile 150 155 160 165 ttc ccc cga ccc ctc ggc tgg gac gtc ctc ctg atc atc ccc gca atg 643 Phe Pro Arg Pro Leu Gly Trp Asp Val Leu Leu Ile Ile Pro Ala Met                 170 175 180 ttc ctc ctg gtg atc aac ggc gtg tgg gta gtc atg ttc ttc ggc atc 691 Phe Leu Leu Val Ile Asn Gly Val Trp Val Val Met Phe Phe Gly Ile             185 190 195 atc gcc acc cgc tac cgc gac gtc tcc ccg ttg cta gaa gcc gga acc 739 Ile Ala Thr Arg Tyr Arg Asp Val Ser Pro Leu Leu Glu Ala Gly Thr         200 205 210 caa ctc ctc ttc tac gtc acc ccc atc gtc tgg atg act tcc acc ctg 787 Gln Leu Leu Phe Tyr Val Thr Pro Ile Val Trp Met Thr Ser Thr Leu     215 220 225 caa tcc cag agc gca gaa atc ggc aac cgc gca cgc ctc gcc gaa ctc 835 Gln Ser Gln Ser Ala Glu Ile Gly Asn Arg Ala Arg Leu Ala Glu Leu 230 235 240 245 aac ccg ctc tac cac tac ctc gaa att gtc cgc gcc ccc atg gtc ggc 883 Asn Pro Leu Tyr His Tyr Leu Glu Ile Val Arg Ala Pro Met Val Gly                 250 255 260 gcc gac ctc ccc gcc tac cac tgg tgg atc gtc ctc gcc ttc aca ttc 931 Ala Asp Leu Pro Ala Tyr His Trp Trp Ile Val Leu Ala Phe Thr Phe             265 270 275 gtc ggc ctt ggc ctt gct ctc ctc gcg atg aag caa tgg cga ttc cgc 979 Val Gly Leu Gly Leu Ala Leu Leu Ala Met Lys Gln Trp Arg Phe Arg         280 285 290 gtc agc tac tgg gta taaggagcac cacatggtat cca 1017 Val Ser Tyr Trp Val     295 <210> 654 <211> 298 <212> PRT <213> Corynebacterium glutamicum <400> 654 Val Gln Glu Gln Ser Lys Gln Lys Asp Leu Gln Ala Asp Ile Ala Arg   1 5 10 15 Ile Thr Ala Val Lys Ser Asp Thr Val Pro Asn Ser Gln Ser Met Thr              20 25 30 Phe Gly Ala Ala Trp Asn Asp Ile Val Arg Gly Phe Lys Gln His Glu          35 40 45 Leu Trp Leu Gln Leu Gly Trp Gln Asp Ile Lys Gln Arg Tyr Arg Arg      50 55 60 Ser Val Leu Gly Pro Leu Trp Ile Thr Ile Ala Thr Gly Val Met Ala  65 70 75 80 Leu Ala Leu Gly Leu Leu Tyr Ser Val Leu Phe Lys Ile Pro Ile Ala                  85 90 95 Glu Phe Leu Pro His Val Thr Val Gly Leu Ile Trp Asn Phe Ile             100 105 110 Ser Gly Cys Ile Lys Glu Gly Ser Asp Ile Phe Ile Asp Asn Glu Gly         115 120 125 Leu Ile Lys Gln Leu Pro Ser Ala Leu Ser Val His Val Tyr Arg Leu     130 135 140 Val Trp Lys Gln Ala Leu Phe Leu Ala His Asn Leu Val Ile Trp Val 145 150 155 160 Ile Leu Met Met Ile Phe Pro Arg Pro Leu Gly Trp Asp Val Leu Leu                 165 170 175 Ile Ile Pro Ala Met Phe Leu Leu Val Ile Asn Gly Val Trp Val Val             180 185 190 Met Phe Phe Gly Ile Ile Ala Thr Arg Tyr Arg Asp Val Ser Pro Leu         195 200 205 Leu Glu Ala Gly Thr Gln Leu Leu Phe Tyr Val Thr Pro Ile Val Trp     210 215 220 Met Thr Ser Thr Leu Gln Ser Gln Ser Ala Glu Ile Gly Asn Arg Ala 225 230 235 240 Arg Leu Ala Glu Leu Asn Pro Leu Tyr His Tyr Leu Glu Ile Val Arg                 245 250 255 Ala Pro Met Val Gly Ala Asp Leu Pro Ala Tyr His Trp Trp Ile Val             260 265 270 Leu Ala Phe Thr Phe Val Gly Leu Gly Leu Ala Leu Leu Ala Met Lys         275 280 285 Gln Trp Arg Phe Arg Val Ser Tyr Trp Val     290 295 <210> 655 <211> 927 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (904) <223> RXN00443 <400> 655 taaacaagga gcgtttaatt tccacccaat cccactgaaa gtttcccacc ccacagttat 60 gctgattaag tactgaactt accgtaggaa aggcactcag gtg aac aaa agt atc 115                                             Val Asn Lys Ser Ile                                               1 5 cgt cga gct ctc tac agt ttc atc act att tcg gcg ggt atc tca ctc 163 Arg Arg Ala Leu Tyr Ser Phe Ile Thr Ile Ser Ala Gly Ile Ser Leu                  10 15 20 gta gcg tgc tct tct tca gac acc gca agc act acc acc cag aat gcc 211 Val Ala Cys Ser Ser Ser Asp Thr Ala Ser Thr Thr Thr Gln Asn Ala              25 30 35 tct gct acc gaa gca gct ggg gtt tcc gga acc gct agc gtt ttc gct 259 Ser Ala Thr Glu Ala Ala Gly Val Ser Gly Thr Ala Ser Val Phe Ala          40 45 50 gcg gcg tct ttg acc aac gtt gct gag gat ctc gcg gct gcg ttc aac 307 Ala Ala Ser Leu Thr Asn Val Ala Glu Asp Leu Ala Ala Ala Phe Asn      55 60 65 gaa gac aat cct gat gca aag ttg gag ttt aac ttc gct ggt tct tcc 355 Glu Asp Asn Pro Asp Ala Lys Leu Glu Phe Asn Phe Ala Gly Ser Ser  70 75 80 85 gcg ctg gtt cgc cag atc agc gaa ggc gca cca tct gat ctg ttc att 403 Ala Leu Val Arg Gln Ile Ser Glu Gly Ala Pro Ser Asp Leu Phe Ile                  90 95 100 tct gcg gac atc gcc aac atg gac gat gcg ctg gca ctt cca gaa ttt 451 Ser Ala Asp Ile Ala Asn Met Asp Asp Ala Leu Ala Leu Pro Glu Phe             105 110 115 gcc ggc gca acc tcg aag gtc atc gct acc aac aag ctg gtg ctg gtc 499 Ala Gly Ala Thr Ser Lys Val Ile Ala Thr Asn Lys Leu Val Leu Val         120 125 130 acc gca gac ggc aac ccc ggc gaa att tca gag ctt gcc gac gtc aag 547 Thr Ala Asp Gly Asn Pro Gly Glu Ile Ser Glu Leu Ala Asp Val Lys     135 140 145 gac tcc ctc gtt gct atc tgc gcc cct gaa gtt cca tgt gga acc atc 595 Asp Ser Leu Val Ala Ile Cys Ala Pro Glu Val Pro Cys Gly Thr Ile 150 155 160 165 acc cac gag gct ttg gac tac gca gac atc gag ttg aac acc agc tct 643 Thr His Glu Ala Leu Asp Tyr Ala Asp Ile Glu Leu Asn Thr Ser Ser                 170 175 180 gag gaa gcc aat gtt gct gat gtc gcc acg aag att tcc acc ggt gca 691 Glu Glu Ala Asn Val Ala Asp Val Ala Thr Lys Ile Ser Thr Gly Ala             185 190 195 gtt gat gcg ggc ttt gtt tac caa acc gac gct cag tct ttg gct aaa 739 Val Asp Ala Gly Phe Val Tyr Gln Thr Asp Ala Gln Ser Leu Ala Lys         200 205 210 act cag gac aac act gtc att gaa ctc gaa ggt atc gac gcc aac gaa 787 Thr Gln Asp Asn Thr Val Ile Glu Leu Glu Gly Ile Asp Ala Asn Glu     215 220 225 tac cca atg gca ttg acc acc acc ggt gaa gac aac gag gta gcg aag 835 Tyr Pro Met Ala Leu Thr Thr Thr Gly Glu Asp Asn Glu Val Ala Lys 230 235 240 245 gct ttc gca gag ttc ctc agc agc gat cgt gcc aag gag atc ctt gcc 883 Ala Phe Ala Glu Phe Leu Ser Ser Asp Arg Ala Lys Glu Ile Leu Ala                 250 255 260 agc tat ggt ttt ggc aca aac taaaaaggct cgtcgaagcg aga 927 Ser Tyr Gly Phe Gly Thr Asn             265 <210> 656 <211> 268 <212> PRT <213> Corynebacterium glutamicum <400> 656 Val Asn Lys Ser Ile Arg Arg Ala Leu Tyr Ser Phe Ile Thr Ile Ser   1 5 10 15 Ala Gly Ile Ser Leu Val Ala Cys Ser Ser Ser Asp Thr Ala Ser Thr              20 25 30 Thr Thr Gln Asn Ala Ser Ala Thr Glu Ala Ala Gly Val Ser Gly Thr          35 40 45 Ala Ser Val Phe Ala Ala Ala Ser Leu Thr Asn Val Ala Glu Asp Leu      50 55 60 Ala Ala Ala Phe Asn Glu Asp Asn Pro Asp Ala Lys Leu Glu Phe Asn  65 70 75 80 Phe Ala Gly Ser Ser Ala Leu Val Arg Gln Ile Ser Glu Gly Ala Pro                  85 90 95 Ser Asp Leu Phe Ile Ser Ala Asp Ile Ala Asn Met Asp Asp Ala Leu             100 105 110 Ala Leu Pro Glu Phe Ala Gly Ala Thr Ser Lys Val Ile Ala Thr Asn         115 120 125 Lys Leu Val Leu Val Thr Ala Asp Gly Asn Pro Gly Glu Ile Ser Glu     130 135 140 Leu Ala Asp Val Lys Asp Ser Leu Val Ala Ile Cys Ala Pro Glu Val 145 150 155 160 Pro Cys Gly Thr Ile Thr His Glu Ala Leu Asp Tyr Ala Asp Ile Glu                 165 170 175 Leu Asn Thr Ser Ser Glu Glu Ala Asn Val Ala Asp Val Ala Thr Lys             180 185 190 Ile Ser Thr Gly Ala Val Asp Ala Gly Phe Val Tyr Gln Thr Asp Ala         195 200 205 Gln Ser Leu Ala Lys Thr Gln Asp Asn Thr Val Ile Glu Leu Glu Gly     210 215 220 Ile Asp Ala Asn Glu Tyr Pro Met Ala Leu Thr Thr Thr Gly Glu Asp 225 230 235 240 Asn Glu Val Ala Lys Ala Phe Ala Glu Phe Leu Ser Ser Asp Arg Ala                 245 250 255 Lys Glu Ile Leu Ala Ser Tyr Gly Phe Gly Thr Asn             260 265 <210> 657 <211> 960 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (937) <223> RXN00444 <400> 657 tacccaatgg cattgaccac caccggtgaa gacaacgagg tagcgaaggc tttcgcagag 60 ttcctcagca gcgatcgtgc caaggagatc cttgccagct atg gtt ttg gca caa 115                                             Met val leu ala gln                                               1 5 act aaa aag gct cgt cga agc gag aat cat atc ctc cca ggg tgg ttg 163 Thr Lys Lys Ala Arg Arg Ser Glu Asn His Ile Leu Pro Gly Trp Leu                  10 15 20 ctc atc cca gcc acc ctg gcc atg ctg ctg atc att gga cct att ttt 211 Leu Ile Pro Ala Thr Leu Ala Met Leu Leu Ile Ile Gly Pro Ile Phe              25 30 35 gct ttg ctg ttg cag atc ccc tgg gat cgg tct tgg gag ttg ctt acc 259 Ala Leu Leu Leu Gln Ile Pro Trp Asp Arg Ser Trp Glu Leu Leu Thr          40 45 50 gcg ccg gaa tct tta gga acc gca cgg tta tct atc gga act gct ctg 307 Ala Pro Glu Ser Leu Gly Thr Ala Arg Leu Ser Ile Gly Thr Ala Leu      55 60 65 ttt tct acc gcg cta tgc gca att gtg ggt ttc ccg cta gcg ttg gcg 355 Phe Ser Thr Ala Leu Cys Ala Ile Val Gly Phe Pro Leu Ala Leu Ala  70 75 80 85 ctg cat tta tat gag cgt tcg cac ccc agg gtg aca tca gtt ttg acg 403 Leu His Leu Tyr Glu Arg Ser His Pro Arg Val Thr Ser Val Leu Thr                  90 95 100 gtg ctg gtt tat gcg cct ttg gtg ttg tcg ccg gtg gtg tct ggt ttg 451 Val Leu Val Tyr Ala Pro Leu Val Leu Ser Pro Val Val Ser Gly Leu             105 110 115 gcg ctg act ttt ctg tgg ggc agg cgt ggt ttt tta ggt tct tgg ctt 499 Ala Leu Thr Phe Leu Trp Gly Arg Arg Gly Phe Leu Gly Ser Trp Leu         120 125 130 gat cag gtt gga ttg ccg att gca ttt acc acc acg gct gtg gtg ttt 547 Asp Gln Val Gly Leu Pro Ile Ala Phe Thr Thr Thr Ala Val Val Phe     135 140 145 gcc cag gtg ttt gta gcg ttg cca ttt ttc att tcc act gtg act act 595 Ala Gln Val Phe Val Ala Leu Pro Phe Phe Ile Ser Thr Val Thr Thr 150 155 160 165 gca ctg cgt ggc att cca aaa cag ttt gag gaa atc gca gct act gaa 643 Ala Leu Arg Gly Ile Pro Lys Gln Phe Glu Glu Ile Ala Ala Thr Glu                 170 175 180 ggc gca acc cgc tgg gag atc atg cac aag atg atc att ccg ctg gcg 691 Gly Ala Thr Arg Trp Glu Ile Met His Lys Met Ile Ile Pro Leu Ala             185 190 195 atg cct gga att ttc acc ggt atg att ttg gga ttc gcc agg gcc ttg 739 Met Pro Gly Ile Phe Thr Gly Met Ile Leu Gly Phe Ala Arg Ala Leu         200 205 210 ggc gag tat ggt gcg aca ctg act ttt gct gga aat att gca ggt gtt 787 Gly Glu Tyr Gly Ala Thr Leu Thr Phe Ala Gly Asn Ile Ala Gly Val     215 220 225 acc cgc acc att ccg ttg cat att gag ctt ggt ttg agt tcc aat gac 835 Thr Arg Thr Ile Pro Leu His Ile Glu Leu Gly Leu Ser Ser Asn Asp 230 235 240 245 atg gat aaa gcc ttg gga gcg gtg att atg ctt ttg gct gtc tat gtc 883 Met Asp Lys Ala Leu Gly Ala Val Ile Met Leu Leu Ala Val Tyr Val                 250 255 260 ctc atc att gga gcc atc gga gcg tta cga ttg ttt tcc aag gtg aga 931 Leu Ile Ile Gly Ala Ile Gly Ala Leu Arg Leu Phe Ser Lys Val Arg             265 270 275 aag gtt taattgatgt ctcgttcgcc gga 960 Lys val <210> 658 <211> 279 <212> PRT <213> Corynebacterium glutamicum <400> 658 Met Val Leu Ala Gln Thr Lys Lys Ala Arg Arg Ser Glu Asn His Ile   1 5 10 15 Leu Pro Gly Trp Leu Leu Ile Pro Ala Thr Leu Ala Met Leu Leu Ile              20 25 30 Ile Gly Pro Ile Phe Ala Leu Leu Leu Gln Ile Pro Trp Asp Arg Ser          35 40 45 Trp Glu Leu Leu Thr Ala Pro Glu Ser Leu Gly Thr Ala Arg Leu Ser      50 55 60 Ile Gly Thr Ala Leu Phe Ser Thr Ala Leu Cys Ala Ile Val Gly Phe  65 70 75 80 Pro Leu Ala Leu Ala Leu His Leu Tyr Glu Arg Ser His Pro Arg Val                  85 90 95 Thr Ser Val Leu Thr Val Leu Val Tyr Ala Pro Leu Val Leu Ser Pro             100 105 110 Val Val Ser Gly Leu Ala Leu Thr Phe Leu Trp Gly Arg Arg Gly Phe         115 120 125 Leu Gly Ser Trp Leu Asp Gln Val Gly Leu Pro Ile Ala Phe Thr Thr     130 135 140 Thr Ala Val Val Phe Ala Gln Val Phe Val Ala Leu Pro Phe Phe Ile 145 150 155 160 Ser Thr Val Thr Thr Ala Leu Arg Gly Ile Pro Lys Gln Phe Glu Glu                 165 170 175 Ile Ala Ala Thr Glu Gly Ala Thr Arg Trp Glu Ile Met His Lys Met             180 185 190 Ile Ile Pro Leu Ala Met Pro Gly Ile Phe Thr Gly Met Ile Leu Gly         195 200 205 Phe Ala Arg Ala Leu Gly Glu Tyr Gly Ala Thr Leu Thr Phe Ala Gly     210 215 220 Asn Ile Ala Gly Val Thr Arg Thr Ile Pro Leu His Ile Glu Leu Gly 225 230 235 240 Leu Ser Ser Asn Asp Met Asp Lys Ala Leu Gly Ala Val Ile Met Leu                 245 250 255 Leu Ala Val Tyr Val Leu Ile Ile Gly Ala Ile Gly Ala Leu Arg Leu             260 265 270 Phe Ser Lys Val Arg Lys Val         275 <210> 659 <211> 594 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (1) ... (594) <223> RXN00193 <220> <221> misc_feature <222> 11 <223> n indicates any nucleotide <220> <221> VARIANT <222> 4 Xaa = Phe, Ser, Tyr, or Cys <400> 659 aaa gct ttc tnc caa cgc gaa ggt ttc atc tca gcc ttc ggt ttc acc 48 Lys Ala Phe Xaa Gln Arg Glu Gly Phe Ile Ser Ala Phe Gly Phe Thr   1 5 10 15 gtc ctc gtg gtc atc gtc tcc gtg atc aca gtc aac atc ttc gcc ttc 96 Val Leu Val Val Ile Val Ser Val Ile Thr Val Asn Ile Phe Ala Phe              20 25 30 ctc ttg gcg tgg ttg ctg acc cgc aaa ctc cgc ggt acc aac ttt ttc 144 Leu Leu Ala Trp Leu Leu Thr Arg Lys Leu Arg Gly Thr Asn Phe Phe          35 40 45 cgc aca gtc ttc ttt atg ccg aac ctt atc ggc ggc att gtg ctg ggt 192 Arg Thr Val Phe Phe Met Pro Asn Leu Ile Gly Gly Ile Val Leu Gly      50 55 60 tat acc tgg cag acc atg atc aac gcc gtg ctt tcg cac tat gcc acg 240 Tyr Thr Trp Gln Thr Met Ile Asn Ala Val Leu Ser His Tyr Ala Thr  65 70 75 80 act att agc gcg gac tgg aaa ttc ggc tac gcc ggc ctc atc atg cta 288 Thr Ile Ser Ala Asp Trp Lys Phe Gly Tyr Ala Gly Leu Ile Met Leu                  85 90 95 ctt aac tgg cag ctc atc ggc tac atg atg atc att tac atc gcc ggc 336 Leu Asn Trp Gln Leu Ile Gly Tyr Met Met Ile Ile Tyr Ile Ala Gly             100 105 110 ctg caa aac gtc cca cca gag ctc att gag gct gcc gaa ctc gac ggc 384 Leu Gln Asn Val Pro Pro Glu Leu Ile Glu Ala Ala Glu Leu Asp Gly         115 120 125 gtc aac aag tgg gag atg ctg cgg cac gtc act att ccg atg gtc atg 432 Val Asn Lys Trp Glu Met Leu Arg His Val Thr Ile Pro Met Val Met     130 135 140 cca tcc atc acc atc tgc ctc ttt ttg act ttg tcg aac tcc ttt aag 480 Pro Ser Ile Thr Ile Cys Leu Phe Leu Thr Leu Ser Asn Ser Phe Lys 145 150 155 160 ctc ttc gac cag aac ctg gcg ctg acc aac ggc gct cct ggc ggg caa 528 Leu Phe Asp Gln Asn Leu Ala Leu Thr Asn Gly Ala Pro Gly Gly Gln                 165 170 175 act gag atg gtg gcg ctc aac atc atc aac acg ctg ttt aac cgt atg 576 Thr Glu Met Val Ala Leu Asn Ile Ile Asn Thr Leu Phe Asn Arg Met             180 185 190 aat gtc gag ggc gtc ggt 594 Asn Val Glu Gly Val Gly         195 <210> 660 <211> 198 <212> PRT <213> Corynebacterium glutamicum <220> <221> VARIANT <222> 4 Xaa = Phe, Ser, Tyr, or Cys <400> 660 Lys Ala Phe Xaa Gln Arg Glu Gly Phe Ile Ser Ala Phe Gly Phe Thr   1 5 10 15 Val Leu Val Val Ile Val Ser Val Ile Thr Val Asn Ile Phe Ala Phe              20 25 30 Leu Leu Ala Trp Leu Leu Thr Arg Lys Leu Arg Gly Thr Asn Phe Phe          35 40 45 Arg Thr Val Phe Phe Met Pro Asn Leu Ile Gly Gly Ile Val Leu Gly      50 55 60 Tyr Thr Trp Gln Thr Met Ile Asn Ala Val Leu Ser His Tyr Ala Thr  65 70 75 80 Thr Ile Ser Ala Asp Trp Lys Phe Gly Tyr Ala Gly Leu Ile Met Leu                  85 90 95 Leu Asn Trp Gln Leu Ile Gly Tyr Met Met Ile Ile Tyr Ile Ala Gly             100 105 110 Leu Gln Asn Val Pro Pro Glu Leu Ile Glu Ala Ala Glu Leu Asp Gly         115 120 125 Val Asn Lys Trp Glu Met Leu Arg His Val Thr Ile Pro Met Val Met     130 135 140 Pro Ser Ile Thr Ile Cys Leu Phe Leu Thr Leu Ser Asn Ser Phe Lys 145 150 155 160 Leu Phe Asp Gln Asn Leu Ala Leu Thr Asn Gly Ala Pro Gly Gly Gln                 165 170 175 Thr Glu Met Val Ala Leu Asn Ile Ile Asn Thr Leu Phe Asn Arg Met             180 185 190 Asn Val Glu Gly Val Gly         195 <210> 661 <211> 1053 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (1030) <223> RXN01298 <400> 661 cttaaacgtc accttattta tgcattatgt tggtttcaga ctcgaacaat tcaattagaa 60 aacactaatc ggacatttag gtcacataac atttccgctc gtg tcc aca tta att 115                                             Val Ser Thr Leu Ile                                               1 5 tct gaa ccc gag gtg gat aag cta cgt aaa cgt gcc aag aga tca agg 163 Ser Glu Pro Glu Val Asp Lys Leu Arg Lys Arg Ala Lys Arg Ser Arg                  10 15 20 cgg aca gaa tgg tgg ctt gcc gcc gca ctt ctt gcc cca aac ttg ctt 211 Arg Thr Glu Trp Trp Leu Ala Ala Ala Leu Leu Ala Pro Asn Leu Leu              25 30 35 ctc ttg gcc atc ttt acg tat cgg cca ctg tta gat aac ttc cgg ttg 259 Leu Leu Ala Ile Phe Thr Tyr Arg Pro Leu Leu Asp Asn Phe Arg Leu          40 45 50 tcc ttt ttc aac tgg aac att tcc tcg ccc aca tca acc ttc att ggg 307 Ser Phe Phe Asn Trp Asn Ile Ser Ser Pro Thr Ser Thr Phe Ile Gly      55 60 65 ttt gat aac tac gtt gag ttc ttc act cgt agt gac act ctc caa gtt 355 Phe Asp Asn Tyr Val Glu Phe Phe Thr Arg Ser Asp Thr Leu Gln Val  70 75 80 85 gtt tta aac acc gtc atc ttc acg gca tgt gct gtg atc gga tcg atg 403 Val Leu Asn Thr Val Ile Phe Thr Ala Cys Ala Val Ile Gly Ser Met                  90 95 100 gtg ctc ggt ttg ctc ctg gcc atg ttg ttg gat cag aag ctt ttc ggc 451 Val Leu Gly Leu Leu Leu Ala Met Leu Leu Asp Gln Lys Leu Phe Gly             105 110 115 cgt aac ttt gtg cgt tcc atg gtg ttt gcc ccg ttt gtg att tcc ggt 499 Arg Asn Phe Val Arg Ser Met Val Phe Ala Pro Phe Val Ile Ser Gly         120 125 130 gct gcc att ggt gtt gct ttc cag ttc gtt ttt gac cct aat ttt ggt 547 Ala Ala Ile Gly Val Ala Phe Gln Phe Val Phe Asp Pro Asn Phe Gly     135 140 145 ttg gtt cag gac ttg ctg gga cgc atc ggc gtt gat tcg cca cag ttc 595 Leu Val Gln Asp Leu Leu Gly Arg Ile Gly Val Asp Ser Pro Gln Phe 150 155 160 165 tac caa aac cct aac tgg gca ttg ttc atg gtg acg ttc act ttc gtg 643 Tyr Gln Asn Pro Asn Trp Ala Leu Phe Met Val Thr Phe Thr Phe Val                 170 175 180 tgg aag aac ttg ggc tac tcc ttt gtt atc tac ctg gct gca ttg cag 691 Trp Lys Asn Leu Gly Tyr Ser Phe Val Ile Tyr Leu Ala Ala Leu Gln             185 190 195 ggg cta aac aag gat ttg tct gag gcc gca ccg gtg gat ggc gcg agc 739 Gly Leu Asn Lys Asp Leu Ser Glu Ala Ala Pro Val Asp Gly Ala Ser         200 205 210 gcg tgg aca cgt ttt tgg aag gtt act ctt ccg cag ctt cgc cca acc 787 Ala Trp Thr Arg Phe Trp Lys Val Thr Leu Pro Gln Leu Arg Pro Thr     215 220 225 acg ttc ttc ctt tct att act gtc acg ctg aac tcg gtt cag gtc ttc 835 Thr Phe Phe Leu Ser Ile Thr Val Thr Leu Asn Ser Val Gln Val Phe 230 235 240 245 gac atc att cac acc atg act cgt ggt ggc ccc ttg ggt aac ggt acg 883 Asp Ile Ile His Thr Met Thr Arg Gly Gly Pro Leu Gly Asn Gly Thr                 250 255 260 acc acc ttg gtt tac cag gtg tac acc gag act ttc acc aac tat cgc 931 Thr Thr Leu Val Tyr Gln Val Tyr Thr Glu Thr Phe Thr Asn Tyr Arg             265 270 275 gcg gga tat ggt gca aca atc gca acg att ttg ttc ctg ttg ctg ctg 979 Ala Gly Tyr Gly Ala Thr Ile Ala Thr Ile Leu Phe Leu Leu Leu Leu         280 285 290 att atc act gtt atc cag gtt cga tac atg gat aag gag aac aag cag 1027 Ile Ile Thr Val Ile Gln Val Arg Tyr Met Asp Lys Glu Asn Lys Gln     295 300 305 aaa tgatctcgac tgatagaaac gtt 1053 Lys 310 <210> 662 <211> 310 <212> PRT <213> Corynebacterium glutamicum <400> 662 Val Ser Thr Leu Ile Ser Glu Pro Glu Val Asp Lys Leu Arg Lys Arg   1 5 10 15 Ala Lys Arg Ser Arg Arg Thr Glu Trp Trp Leu Ala Ala Ala Leu Leu              20 25 30 Ala Pro Asn Leu Leu Leu Leu Ala Ile Phe Thr Tyr Arg Pro Leu Leu          35 40 45 Asp Asn Phe Arg Leu Ser Phe Phe Asn Trp Asn Ile Ser Ser Pro Thr      50 55 60 Ser Thr Phe Ile Gly Phe Asp Asn Tyr Val Glu Phe Phe Thr Arg Ser  65 70 75 80 Asp Thr Leu Gln Val Val Leu Asn Thr Val Ile Phe Thr Ala Cys Ala                  85 90 95 Val Ile Gly Ser Met Val Leu Gly Leu Leu Leu Ala Met Leu Leu Asp             100 105 110 Gln Lys Leu Phe Gly Arg Asn Phe Val Arg Ser Met Val Phe Ala Pro         115 120 125 Phe Val Ile Ser Gly Ala Ala Ile Gly Val Ala Phe Gln Phe Val Phe     130 135 140 Asp Pro Asn Phe Gly Leu Val Gln Asp Leu Leu Gly Arg Ile Gly Val 145 150 155 160 Asp Ser Pro Gln Phe Tyr Gln Asn Pro Asn Trp Ala Leu Phe Met Val                 165 170 175 Thr Phe Thr Phe Val Trp Lys Asn Leu Gly Tyr Ser Phe Val Ile Tyr             180 185 190 Leu Ala Ala Leu Gln Gly Leu Asn Lys Asp Leu Ser Glu Ala Ala Pro         195 200 205 Val Asp Gly Ala Ser Ala Trp Thr Arg Phe Trp Lys Val Thr Leu Pro     210 215 220 Gln Leu Arg Pro Thr Thr Phe Phe Leu Ser Ile Thr Val Thr Leu Asn 225 230 235 240 Ser Val Gln Val Phe Asp Ile Ile His Thr Met Thr Arg Gly Gly Pro                 245 250 255 Leu Gly Asn Gly Thr Thr Thr Leu Val Tyr Gln Val Tyr Thr Glu Thr             260 265 270 Phe Thr Asn Tyr Arg Ala Gly Tyr Gly Ala Thr Ile Ala Thr Ile Leu         275 280 285 Phe Leu Leu Leu Leu Ile Ile Thr Val Ile Gln Val Arg Tyr Met Asp     290 295 300 Lys Glu Asn Lys Gln Lys 305 310 <210> 663 <211> 1182 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101) .. (1159) <223> RXA01737 <400> 663 ctttgagccg aacgatctgc cgactcaaga agaactagcc cggctgctca gtcaggaatg 60 atgcgcctaa gatcaaacaa gaatgaaagg acggtgaaca atg ggc cga atg aaa 115                                             Met Gly Arg Met Lys                                               1 5 aac gat ggt gaa ctc gcg gat ctg ccg gat cat gca ctt ttg agc att 163 Asn Asp Gly Glu Leu Ala Asp Leu Pro Asp His Ala Leu Leu Ser Ile                  10 15 20 att cga atc ccg cag gcg gcg aaa aga agc ccc tgg gcg ctg atc tta 211 Ile Arg Ile Pro Gln Ala Ala Lys Arg Ser Pro Trp Ala Leu Ile Leu              25 30 35 acg cgc atc gga tac gcg atg gtg ctg ctg gtt atc gtc acc atg gtt 259 Thr Arg Ile Gly Tyr Ala Met Val Leu Leu Val Ile Val Thr Met Val          40 45 50 gtc tat ttt gac cgc aac gga tac tcc gaa gac ctc acg ttc atc gac 307 Val Tyr Phe Asp Arg Asn Gly Tyr Ser Glu Asp Leu Thr Phe Ile Asp      55 60 65 gcg ttg tac tat tcc aca gtc tcg ttg acc acc gtg ggc tac ggc gat 355 Ala Leu Tyr Tyr Ser Thr Val Ser Leu Thr Thr Val Gly Tyr Gly Asp  70 75 80 85 atc acc ccg gtg acg caa tcg gca cgc ctg atc aac atc atc gtc ctc 403 Ile Thr Pro Val Thr Gln Ser Ala Arg Leu Ile Asn Ile Ile Val Leu                  90 95 100 acc cca gca cgc atc ggc ttc ctg atc ctc ctg gtc ggc acc acc ttg 451 Thr Pro Ala Arg Ile Gly Phe Leu Ile Leu Leu Val Gly Thr Thr Leu             105 110 115 tca gtg ctc acc gaa gaa tcg cgc cgg gcc ctg caa atc caa cgt tgg 499 Ser Val Leu Thr Glu Glu Ser Arg Arg Ala Leu Gln Ile Gln Arg Trp         120 125 130 aga aaa cgc atg cgc aac cac acc gtc gtt gtc gga tac gga acc aaa 547 Arg Lys Arg Met Arg Asn His Thr Val Val Val Gly Tyr Gly Thr Lys     135 140 145 ggt cgc tcc gcg gtc gct gca ctg ctt ggc gac ggc gtc ccc gcc aac 595 Gly Arg Ser Ala Val Ala Ala Leu Leu Gly Asp Gly Val Pro Ala Asn 150 155 160 165 cag atc gtt gtt atc gac acc gat caa gtc tcc ctc gac gcc gcc aac 643 Gln Ile Val Val Ile Asp Thr Asp Gln Val Ser Leu Asp Ala Ala Asn                 170 175 180 aac agc gga ctc gtc acc gtc aaa ggc tcc gcc acc aaa gca gat gtg 691 Asn Ser Gly Leu Val Thr Val Lys Gly Ser Ala Thr Lys Ala Asp Val             185 190 195 ttg cgt cta gct ggc gtg tca cga gcg cgc gcc gtc gtc gtg gca ccg 739 Leu Arg Leu Ala Gly Val Ser Arg Ala Arg Ala Val Val Val Ala Pro         200 205 210 aac ctg gac gat act gca gtt ctg gtg act cta tcg gtg cga gaa atc 787 Asn Leu Asp Asp Thr Ala Val Leu Val Thr Leu Ser Val Arg Glu Ile     215 220 225 gcg ccg cag gca atg att gtg gcc agt gtc cga gaa tct gaa aac caa 835 Ala Pro Gln Ala Met Ile Val Ala Ser Val Arg Glu Ser Glu Asn Gln 230 235 240 245 cac ctc ctc gaa caa tcc ggt gcg gac tcg gtt gtg atc tcc tca gaa 883 His Leu Leu Glu Gln Ser Gly Ala Asp Ser Val Val Ile Ser Ser Glu                 250 255 260 acc gct ggc cga atg ctc ggt ctg gca aca gtt acc cca tcg gtt gtg 931 Thr Ala Gly Arg Met Leu Gly Leu Ala Thr Val Thr Pro Ser Val Val             265 270 275 gag atg atg gaa gac ctc ctc tca ccc gac gaa gga ttc tcc gtt gcc 979 Glu Met Met Glu Asp Leu Leu Ser Pro Asp Glu Gly Phe Ser Val Ala         280 285 290 gaa cga cta gtc ggt gag gat gaa atc ggc tcc aac cca cga cac ctc 1027 Glu Arg Leu Val Gly Glu Asp Glu Ile Gly Ser Asn Pro Arg His Leu     295 300 305 gct gac atc gtc ctc ggt gtt gtt cga tcc ggt gag ctc tac cgc atc 1075 Ala Asp Ile Val Leu Gly Val Val Arg Ser Gly Glu Leu Tyr Arg Ile 310 315 320 325 gac tcc cca gaa gca gaa act gta gag ccc ggc gat cgt ctc ctt tac 1123 Asp Ser Pro Glu Ala Glu Thr Val Glu Pro Gly Asp Arg Leu Leu Tyr                 330 335 340 gtt cgc cga gta ttt agc gag gag gta aat gac aaa tgagaattct 1169 Val Arg Arg Val Phe Ser Glu Glu Val Asn Asp Lys             345 350 tcccatcggc ccc 1182 <210> 664 <211> 353 <212> PRT <213> Corynebacterium glutamicum <400> 664 Met Gly Arg Met Lys Asn Asp Gly Glu Leu Ala Asp Leu Pro Asp His   1 5 10 15 Ala Leu Leu Ser Ile Ile Arg Ile Pro Gln Ala Ala Lys Arg Ser Pro              20 25 30 Trp Ala Leu Ile Leu Thr Arg Ile Gly Tyr Ala Met Val Leu Leu Val          35 40 45 Ile Val Thr Met Val Val Tyr Phe Asp Arg Asn Gly Tyr Ser Glu Asp      50 55 60 Leu Thr Phe Ile Asp Ala Leu Tyr Tyr Ser Thr Val Ser Leu Thr Thr  65 70 75 80 Val Gly Tyr Gly Asp Ile Thr Pro Val Thr Gln Ser Ala Arg Leu Ile                  85 90 95 Asn Ile Ile Val Leu Thr Pro Ala Arg Ile Gly Phe Leu Ile Leu Leu             100 105 110 Val Gly Thr Thr Leu Ser Val Leu Thr Glu Glu Ser Arg Arg Ala Leu         115 120 125 Gln Ile Gln Arg Trp Arg Lys Arg Met Arg Asn His Thr Val Val Val     130 135 140 Gly Tyr Gly Thr Lys Gly Arg Ser Ala Val Ala Ala Leu Leu Gly Asp 145 150 155 160 Gly Val Pro Ala Asn Gln Ile Val Val Ile Asp Thr Asp Gln Val Ser                 165 170 175 Leu Asp Ala Ala Asn Asn Ser Gly Leu Val Thr Val Lys Gly Ser Ala             180 185 190 Thr Lys Ala Asp Val Leu Arg Leu Ala Gly Val Ser Arg Ala Arg Ala         195 200 205 Val Val Val Ala Pro Asn Leu Asp Asp Thr Ala Val Leu Val Thr Leu     210 215 220 Ser Val Arg Glu Ile Ala Pro Gln Ala Met Ile Val Ala Ser Val Arg 225 230 235 240 Glu Ser Glu Asn Gln His Leu Leu Glu Gln Ser Gly Ala Asp Ser Val                 245 250 255 Val Ile Ser Ser Glu Thr Ala Gly Arg Met Leu Gly Leu Ala Thr Val             260 265 270 Thr Pro Ser Val Val Glu Met Met Glu Asp Leu Leu Ser Pro Asp Glu         275 280 285 Gly Phe Ser Val Ala Glu Arg Leu Val Gly Glu Asp Glu Ile Gly Ser     290 295 300 Asn Pro Arg His Leu Ala Asp Ile Val Leu Gly Val Val Arg Ser Gly 305 310 315 320 Glu Leu Tyr Arg Ile Asp Ser Pro Glu Ala Glu Thr Val Glu Pro Gly                 325 330 335 Asp Arg Leu Leu Tyr Val Arg Arg Val Phe Ser Glu Glu Val Asn Asp             340 345 350 Lys <210> 665 <211> 2007 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1984) <223> RXN02348 <400> 665 aaagacccga gccgaagccc tggcctgcgc atacttcctt gtcaacgctc gctgggatta 60 ggtcttttct gagcgctagc atttctccac tcaaaggagc atg ctt aac cgc atg 115                                             Met Leu Asn Arg Met                                               1 5 aaa agt gcg cgg cca aaa tca gtc gct cca aaa tcc gga caa gct tta 163 Lys Ser Ala Arg Pro Lys Ser Val Ala Pro Lys Ser Gly Gln Ala Leu                  10 15 20 ctc act ctc ggt gcc cta ggt gtt gtg ttc ggc gac atc ggc acc agc 211 Leu Thr Leu Gly Ala Leu Gly Val Val Phe Gly Asp Ile Gly Thr Ser              25 30 35 ccc ctg tac tca ctt cac act gca ttc agc atg cag cac aac aaa gtc 259 Pro Leu Tyr Ser Leu His Thr Ala Phe Ser Met Gln His Asn Lys Val          40 45 50 gaa gtc act cag gaa aat gtg tac ggc atc atc tcc atg gtg ttg tgg 307 Glu Val Thr Gln Glu Asn Val Tyr Gly Ile Ile Ser Met Val Leu Trp      55 60 65 acc atc act ttg atc gtc acc gtc aaa tac gtc atg ctg gtc acc cga 355 Thr Ile Thr Leu Ile Val Thr Val Lys Tyr Val Met Leu Val Thr Arg  70 75 80 85 gct gac aac caa gga caa ggt ggc atc ctg gcg ctc gtt gct ttg ctg 403 Ala Asp Asn Gln Gly Gln Gly Gly Ile Leu Ala Leu Val Ala Leu Leu                  90 95 100 aaa aac cgt ggg cac tgg gga aaa ttc gtg gca gta gcc ggc atg ttg 451 Lys Asn Arg Gly His Trp Gly Lys Phe Val Ala Val Ala Gly Met Leu             105 110 115 ggc gcc gca ttg ttt tat ggc gat gtg gtg atc acc ccg gcg atc tct 499 Gly Ala Ala Leu Phe Tyr Gly Asp Val Val Ile Thr Pro Ala Ile Ser         120 125 130 gtt ctc agc gca aca gaa ggc ttg acg gtt atc tcc cca agc ttt gag 547 Val Leu Ser Ala Thr Glu Gly Leu Thr Val Ile Ser Pro Ser Phe Glu     135 140 145 cgc ttc att ctg ccc gta tct ctc gca gtt ctg atc gct att ttt gca 595 Arg Phe Ile Leu Pro Val Ser Leu Ala Val Leu Ile Ala Ile Phe Ala 150 155 160 165 atc caa ccg ctc ggt aca gaa aaa gtc ggc aaa gcc ttc ggc ccc atc 643 Ile Gln Pro Leu Gly Thr Glu Lys Val Gly Lys Ala Phe Gly Pro Ile                 170 175 180 atg ttg ctg tgg ttt gtc acc ctt gca gga ttg gga att ccg caa atc 691 Met Leu Leu Trp Phe Val Thr Leu Ala Gly Leu Gly Ile Pro Gln Ile             185 190 195 atc ggg cac cca gaa atc ttg cag agc ttg tct cca cat tgg gcc ctg 739 Ile Gly His Pro Glu Ile Leu Gln Ser Leu Ser Pro His Trp Ala Leu         200 205 210 cgc ttg att gtg gct gag cct ttc caa gca ttt gtg ctg ctt ggt gcc 787 Arg Leu Ile Val Ala Glu Pro Phe Gln Ala Phe Val Leu Leu Gly Ala     215 220 225 gtt gtc ctg aca gta acg ggt gcg gaa gcg ctc tac gct gat atg ggc 835 Val Val Leu Thr Val Thr Gly Ala Glu Ala Leu Tyr Ala Asp Met Gly 230 235 240 245 cat ttt ggg gcg agg cca atc aga gtg gcg tgg ttt tgc gtc gtc atg 883 His Phe Gly Ala Arg Pro Ile Arg Val Ala Trp Phe Cys Val Val Met                 250 255 260 cct gct tta atc ttg acg tat ttg ggg cag ggc gcc ttg gtg atc aac 931 Pro Ala Leu Ile Leu Thr Tyr Leu Gly Gln Gly Ala Leu Val Ile Asn             265 270 275 cag cct gaa gcg gtg cgc aac ccc atg ttt tat ctc gcg ccg gaa ggt 979 Gln Pro Glu Ala Val Arg Asn Pro Met Phe Tyr Leu Ala Pro Glu Gly         280 285 290 ctg cgg att ccg ttg gtt att ttg gcg acc atc gct acg gtg atc gca 1027 Leu Arg Ile Pro Leu Val Ile Leu Ala Thr Ile Ala Thr Val Ile Ala     295 300 305 tcg cag gcc gtg att tct ggt gcg tat tca ttg acc aag cag gcc gtg 1075 Ser Gln Ala Val Ile Ser Gly Ala Tyr Ser Leu Thr Lys Gln Ala Val 310 315 320 325 aat ttg aaa ctg ctg cca cgc atg gtg atc cgg cat acc tcc cgc aaa 1123 Asn Leu Lys Leu Leu Pro Arg Met Val Ile Arg His Thr Ser Arg Lys                 330 335 340 gag gaa ggc cag atc tat atg cca ctg gtt aat gga ttg ctg ttt gta 1171 Glu Glu Gly Gln Ile Tyr Met Pro Leu Val Asn Gly Leu Leu Phe Val             345 350 355 tcc gtg atg gtt gtg gtg ctg gta ttc cga tcc tct gaa agc ctc gcc 1219 Ser Val Met Val Val Val Leu Val Phe Arg Ser Ser Glu Ser Leu Ala         360 365 370 agc gcg tac gga ctt gca gtg acc gga acc ttg gtg ctg gtc agc gtc 1267 Ser Ala Tyr Gly Leu Ala Val Thr Gly Thr Leu Val Leu Val Ser Val     375 380 385 ctg tat ctg atc tat gtt cac acc aca tgg tgg aaa aca gcg ctg ttc 1315 Leu Tyr Leu Ile Tyr Val His Thr Thr Trp Trp Lys Thr Ala Leu Phe 390 395 400 405 att gtg ctc atc ggt att cca gaa gta ctt cta ttc gcc tcg aac acc 1363 Ile Val Leu Ile Gly Ile Pro Glu Val Leu Leu Phe Ala Ser Asn Thr                 410 415 420 acg aaa att cac gac ggt ggc tgg ctt cca cta ctt att gcg gcc gtg 1411 Thr Lys Ile His Asp Gly Gly Trp Leu Pro Leu Leu Ile Ala Ala Val             425 430 435 ctc atc gtg gtg atg cgg acc tgg gag tgg gga agt gac cgc gtc aat 1459 Leu Ile Val Val Met Arg Thr Trp Glu Trp Gly Ser Asp Arg Val Asn         440 445 450 cag gaa cgc gca gag ctg gaa ctt ccc atg gat aag ttc ttg gag aaa 1507 Gln Glu Arg Ala Glu Leu Glu Leu Pro Met Asp Lys Phe Leu Glu Lys     455 460 465 ctc gat cag cca cac aat att ggt ctg cgt aaa gtt gcc gaa gtg gca 1555 Leu Asp Gln Pro His Asn Ile Gly Leu Arg Lys Val Ala Glu Val Ala 470 475 480 485 gta ttt cca cat ggc acc agc gat act gtc ccg ttg tca ttg gtt cgc 1603 Val Phe Pro His Gly Thr Ser Asp Thr Val Pro Leu Ser Leu Val Arg                 490 495 500 tgc gtg aaa gac ctc aag ctt tta tac cga gag atc gtg atc gtt cga 1651 Cys Val Lys Asp Leu Lys Leu Leu Tyr Arg Glu Ile Val Ile Val Arg             505 510 515 atc gtc caa gaa cac gtt ccg cac gtg cca cca gag gaa cgc gcg gaa 1699 Ile Val Gln Glu His Val Pro His Val Pro Pro Glu Glu Arg Ala Glu         520 525 530 atg gaa gtg ctc cat cac gcc ccg atc aga gtc gtg cga gtt gat ctg 1747 Met Glu Val Leu His His Ala Pro Ile Arg Val Val Arg Val Asp Leu     535 540 545 cac ctt ggt tat ttt gat gag cag aac ctg cct gag cat ctc cat gcc 1795 His Leu Gly Tyr Phe Asp Glu Gln Asn Leu Pro Glu His Leu His Ala 550 555 560 565 att gac cca aca tgg gat aac gcc acc tac ttc ctg tct gcc ctg act 1843 Ile Asp Pro Thr Trp Asp Asn Ala Thr Tyr Phe Leu Ser Ala Leu Thr                 570 575 580 ctt cgg agc agg ttg cct gga aag att gct ggc tgg cgt gat cgt ttg 1891 Leu Arg Ser Arg Leu Pro Gly Lys Ile Ala Gly Trp Arg Asp Arg Leu             585 590 595 tat ctt tcg atg gaa cgt aat cag gca tct cga act gag tct ttc aaa 1939 Tyr Leu Ser Met Glu Arg Asn Gln Ala Ser Arg Thr Glu Ser Phe Lys         600 605 610 ttg caa cca agc aaa acc atc acg gtt gga aca gag ctg cac ctt 1984 Leu Gln Pro Ser Lys Thr Ile Thr Val Gly Thr Glu Leu His Leu     615 620 625 taatcaggca gttgctggcc aac 2007 <210> 666 <211> 628 <212> PRT <213> Corynebacterium glutamicum <400> 666 Met Leu Asn Arg Met Lys Ser Ala Arg Pro Lys Ser Val Ala Pro Lys   1 5 10 15 Ser Gly Gln Ala Leu Leu Thr Leu Gly Ala Leu Gly Val Val Phe Gly              20 25 30 Asp Ile Gly Thr Ser Pro Leu Tyr Ser Leu His Thr Ala Phe Ser Met          35 40 45 Gln His Asn Lys Val Glu Val Thr Gln Glu Asn Val Tyr Gly Ile Ile      50 55 60 Ser Met Val Leu Trp Thr Ile Thr Leu Ile Val Thr Val Lys Tyr Val  65 70 75 80 Met Leu Val Thr Arg Ala Asp Asn Gln Gly Gln Gly Gly Ile Leu Ala                  85 90 95 Leu Val Ala Leu Leu Lys Asn Arg Gly His Trp Gly Lys Phe Val Ala             100 105 110 Val Ala Gly Met Leu Gly Ala Ala Leu Phe Tyr Gly Asp Val Val Ile         115 120 125 Thr Pro Ala Ile Ser Val Leu Ser Ala Thr Glu Gly Leu Thr Val Ile     130 135 140 Ser Pro Ser Phe Glu Arg Phe Ile Leu Pro Val Ser Leu Ala Val Leu 145 150 155 160 Ile Ala Ile Phe Ala Ile Gln Pro Leu Gly Thr Glu Lys Val Gly Lys                 165 170 175 Ala Phe Gly Pro Ile Met Leu Leu Trp Phe Val Thr Leu Ala Gly Leu             180 185 190 Gly Ile Pro Gln Ile Ile Gly His Pro Glu Ile Leu Gln Ser Leu Ser         195 200 205 Pro His Trp Ala Leu Arg Leu Ile Val Ala Glu Pro Phe Gln Ala Phe     210 215 220 Val Leu Leu Gly Ala Val Val Leu Thr Val Thr Gly Ala Glu Ala Leu 225 230 235 240 Tyr Ala Asp Met Gly His Phe Gly Ala Arg Pro Ile Arg Val Ala Trp                 245 250 255 Phe Cys Val Val Met Pro Ala Leu Ile Leu Thr Tyr Leu Gly Gln Gly             260 265 270 Ala Leu Val Ile Asn Gln Pro Glu Ala Val Arg Asn Pro Met Phe Tyr         275 280 285 Leu Ala Pro Glu Gly Leu Arg Ile Pro Leu Val Ile Leu Ala Thr Ile     290 295 300 Ala Thr Val Ile Ala Ser Gln Ala Val Ile Ser Gly Ala Tyr Ser Leu 305 310 315 320 Thr Lys Gln Ala Val Asn Leu Lys Leu Leu Pro Arg Met Val Ile Arg                 325 330 335 His Thr Ser Arg Lys Glu Glu Gly Gln Ile Tyr Met Pro Leu Val Asn             340 345 350 Gly Leu Leu Phe Val Ser Val Met Val Val Le Leu Val Phe Arg Ser         355 360 365 Ser Glu Ser Leu Ala Ser Ala Tyr Gly Leu Ala Val Thr Gly Thr Leu     370 375 380 Val Leu Val Ser Val Leu Tyr Leu Ile Tyr Val His Thr Thr Trp Trp 385 390 395 400 Lys Thr Ala Leu Phe Ile Val Leu Ile Gly Ile Pro Glu Val Leu Leu                 405 410 415 Phe Ala Ser Asn Thr Thr Lys Ile His Asp Gly Gly Trp Leu Pro Leu             420 425 430 Leu Ile Ala Ala Val Leu Ile Val Val Met Arg Thr Trp Glu Trp Gly         435 440 445 Ser Asp Arg Val Asn Gln Glu Arg Ala Glu Leu Glu Leu Pro Met Asp     450 455 460 Lys Phe Leu Glu Lys Leu Asp Gln Pro His Asn Ile Gly Leu Arg Lys 465 470 475 480 Val Ala Glu Val Ala Val Phe Pro His Gly Thr Ser Asp Thr Val Pro                 485 490 495 Leu Ser Leu Val Arg Cys Val Lys Asp Leu Lys Leu Leu Tyr Arg Glu             500 505 510 Ile Val Ile Val Arg Ile Val Gln Glu His Val Pro His Val Pro Pro         515 520 525 Glu Glu Arg Ala Glu Met Glu Val Leu His His Ala Pro Ile Arg Val     530 535 540 Val Arg Val Asp Leu His Leu Gly Tyr Phe Asp Glu Gln Asn Leu Pro 545 550 555 560 Glu His Leu His Ala Ile Asp Pro Thr Trp Asp Asn Ala Thr Tyr Phe                 565 570 575 Leu Ser Ala Leu Thr Leu Arg Ser Arg Leu Pro Gly Lys Ile Ala Gly             580 585 590 Trp Arg Asp Arg Leu Tyr Leu Ser Met Glu Arg Asn Gln Ala Ser Arg         595 600 605 Thr Glu Ser Phe Lys Leu Gln Pro Ser Lys Thr Ile Thr Val Gly Thr     610 615 620 Glu leu his leu 625 <210> 667 <211> 1656 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1633) <223> RXA02426 <400> 667 tgcagcagca taatcaggga aaaataggaa ctgtttactg aaaaactgac aaacctgaca 60 gacctgaccc gaagagacct tattcatgac gatattgttc atg ctc att aca ttg 115                                             Met Leu Ile Thr Leu                                               1 5 ctg ctc gcc acc gtg att gtg gtg gcc atc ggc gat aaa acc gga ctc 163 Leu Leu Ala Thr Val Ile Val Val Ala Ile Gly Asp Lys Thr Gly Leu                  10 15 20 ccc tgg cct gct ttg atg act att gtc gcc gca ggt gga gcg ttg ttg 211 Pro Trp Pro Ala Leu Met Thr Ile Val Ala Ala Gly Gly Ala Leu Leu              25 30 35 cca ttt ttg ccg gaa ttt act atc ccg gcc gat ctg atg ttg cct att 259 Pro Phe Leu Pro Glu Phe Thr Ile Pro Ala Asp Leu Met Leu Pro Ile          40 45 50 ttc att ccg ccg ctg ctg tgg gcg ctg gcg agg aag tca tcg tgg gcg 307 Phe Ile Pro Pro Leu Leu Trp Ala Leu Ala Arg Lys Ser Ser Trp Ala      55 60 65 gtg att agg tcg cag atg tct acc atc atc ac atg tcg gtg ttg ttg 355 Val Ile Arg Ser Gln Met Ser Thr Ile Ile Thr Met Ser Val Leu Leu  70 75 80 85 gtg ttc gtg acc atc gcg gca ctc acg ggt gca tcc atg ctg ttg ctt 403 Val Phe Val Thr Ile Ala Ala Leu Thr Gly Ala Ser Met Leu Leu Leu                  90 95 100 cct ggc att ggt ctt gct ggt gcg atc atg ttg gct gcg gct att gct 451 Pro Gly Ile Gly Leu Ala Gly Ala Ile Met Leu Ala Ala Ala Ile Ala             105 110 115 cca ccg gat cct gtt gct gtt gat gca gtg gcg gaa cct gcg gga atc 499 Pro Pro Asp Pro Val Ala Val Asp Ala Val Ala Glu Pro Ala Gly Ile         120 125 130 ccg aag cgc atc acc acc act ttg cag acg gag ggt ctg ttt aat gat 547 Pro Lys Arg Ile Thr Thr Thr Leu Gln Thr Glu Gly Leu Phe Asn Asp     135 140 145 gca gcc agc atc gtg gcg ttc cat gtg gct tta gct gcc ctg gtc gct 595 Ala Ala Ser Ile Val Ala Phe His Val Ala Leu Ala Ala Leu Val Ala 150 155 160 165 ggt gag gat ttg tcc tgg tca acg ggt gtt ttg gaa ttc ttg tgg tcg 643 Gly Glu Asp Leu Ser Trp Ser Thr Gly Val Leu Glu Phe Leu Trp Ser                 170 175 180 tgt ctt gct gcc gtt att ttg ggc ttg gtt att ggc cgg gcg gct gcg 691 Cys Leu Ala Ala Val Ile Leu Gly Leu Val Ile Gly Arg Ala Ala Ala             185 190 195 tgg ttt acc gat cac gtg agt tcc gtt gag gct cga aat gcg ttt acg 739 Trp Phe Thr Asp His Val Ser Ser Val Glu Ala Arg Asn Ala Phe Thr         200 205 210 tgg gtg ctg ccg ttt gcc att tat gtg gtg gcg gaa gaa atc ggc gga 787 Trp Val Leu Pro Phe Ala Ile Tyr Val Val Ala Glu Glu Ile Gly Gly     215 220 225 tcg ggc gtt atc gcc att gtg atc gct gca gtg gag atg aat tcg agg 835 Ser Gly Val Ile Ala Ile Val Ile Ala Ala Val Glu Met Asn Ser Arg 230 235 240 245 gcg tcg att ggt gcg gag gat cgt cta acg ggt tct gcg ttc tgg gga 883 Ala Ser Ile Gly Ala Glu Asp Arg Leu Thr Gly Ser Ala Phe Trp Gly                 250 255 260 acc att gag gtg ctg ttt act ggc gtt gcc ttt ggt ttg atc ggc ctg 931 Thr Ile Glu Val Leu Phe Thr Gly Val Ala Phe Gly Leu Ile Gly Leu             265 270 275 aat gtg cgc gct gcg att gat gaa gtt gga tct gag ctg tgg cat gcc 979 Asn Val Arg Ala Ala Ile Asp Glu Val Gly Ser Glu Leu Trp His Ala         280 285 290 gtg gtc gtg ggc att gtg ctc tcg gtg gtg gcg atc gtt gtc cgt ggt 1027 Val Val Val Gly Ile Val Leu Ser Val Val Ala Ile Val Val Arg Gly     295 300 305 gtg tgg atg ttc gcg gcg tat aag cgc aat cgt ttc aag atc gat aag 1075 Val Trp Met Phe Ala Ala Tyr Lys Arg Asn Arg Phe Lys Ile Asp Lys 310 315 320 325 aag ggt gcg acc aat agt tca ttg cgg gcg cct ctt cga ctg cag gaa 1123 Lys Gly Ala Thr Asn Ser Ser Leu Arg Ala Pro Leu Arg Leu Gln Glu                 330 335 340 tcg ttg ctg atg acg tgg gcg ggc atg cgc ggt ttg gtg acg ttg gcg 1171 Ser Leu Leu Met Thr Trp Ala Gly Met Arg Gly Leu Val Thr Leu Ala             345 350 355 ctg gtg ctg tct att ccg gag gat att ttc ccg tat cac cac gag ttg 1219 Leu Val Leu Ser Ile Pro Glu Asp Ile Phe Pro Tyr His His Glu Leu         360 365 370 cag gtc att gcg ctg gtc gtt ctc tta atc acc atg gtg ggc cct ggt 1267 Gln Val Ile Ala Leu Val Val Leu Leu Ile Thr Met Val Gly Pro Gly     375 380 385 ttg acg ttg ccg tgg ctg atg cgg aag ctc agc ttg gat aag ggt ccc 1315 Leu Thr Leu Pro Trp Leu Met Arg Lys Leu Ser Leu Asp Lys Gly Pro 390 395 400 405 gat gct gcg ggc gat gag agt atc gcc gcg ctg aca gag agg gct cac 1363 Asp Ala Ala Gly Asp Glu Ser Ile Ala Ala Leu Thr Glu Arg Ala His                 410 415 420 aag gcc gca aca acg tat ttg gtg gat acc acg gag ttg ccg atg gag 1411 Lys Ala Ala Thr Thr Tyr Leu Val Asp Thr Thr Glu Leu Pro Met Glu             425 430 435 cag atg gtg gcg atc aag aat tgg ttc tcg caa gaa att gac gct gat 1459 Gln Met Val Ala Ile Lys Asn Trp Phe Ser Gln Glu Ile Asp Ala Asp         440 445 450 gaa ctg cag gag aac gtc gat aag ctg cat cag cgc gcg cat cat gcg 1507 Glu Leu Gln Glu Asn Val Asp Lys Leu His Gln Arg Ala His His Ala     455 460 465 cgt gtc ggg gca att aag gcg gcc cag gag gag ctg ttg aag gcg cgg 1555 Arg Val Gly Ala Ile Lys Ala Ala Gln Glu Glu Leu Leu Lys Ala Arg 470 475 480 485 cgg gag cgc ggc gtt aat ccg gcc tat gtt gat gag gtg ttg acc aac 1603 Arg Glu Arg Gly Val Asn Pro Ala Tyr Val Asp Glu Val Leu Thr Asn                 490 495 500 att gac cgg atg ctt gtt gcg gct gaa cgc tagataaaca gcagcaggct 1653 Ile Asp Arg Met Leu Val Ala Ala Glu Arg             505 510 gat 1656 <210> 668 <211> 511 <212> PRT <213> Corynebacterium glutamicum <400> 668 Met Leu Ile Thr Leu Leu Leu Ala Thr Val Ile Val Val Ala Ile Gly   1 5 10 15 Asp Lys Thr Gly Leu Pro Trp Pro Ala Leu Met Thr Ile Val Ala Ala              20 25 30 Gly Gly Ala Leu Leu Pro Phe Leu Pro Glu Phe Thr Ile Pro Ala Asp          35 40 45 Leu Met Leu Pro Ile Phe Ile Pro Pro Leu Leu Trp Ala Leu Ala Arg      50 55 60 Lys Ser Ser Trp Ala Val Ile Arg Ser Gln Met Ser Thr Ile Ile Thr  65 70 75 80 Met Ser Val Leu Leu Val Phe Val Thr Ile Ala Leu Thr Gly Ala                  85 90 95 Ser Met Leu Leu Leu Pro Gly Ile Gly Leu Ala Gly Ala Ile Met Leu             100 105 110 Ala Ala Ala Ile Ala Pro Pro Asp Pro Val Ala Val Asp Ala Val Ala         115 120 125 Glu Pro Ala Gly Ile Pro Lys Arg Ile Thr Thr Thr Leu Gln Thr Glu     130 135 140 Gly Leu Phe Asn Asp Ala Ala Ser Ile Val Ala Phe His Val Ala Leu 145 150 155 160 Ala Ala Leu Val Ala Gly Glu Asp Leu Ser Trp Ser Thr Gly Val Leu                 165 170 175 Glu Phe Leu Trp Ser Cys Leu Ala Ala Val Ile Leu Gly Leu Val Ile             180 185 190 Gly Arg Ala Ala Ala Trp Phe Thr Asp His Val Ser Ser Val Glu Ala         195 200 205 Arg Asn Ala Phe Thr Trp Val Leu Pro Phe Ala Ile Tyr Val Val Ala     210 215 220 Glu Glu Ile Gly Gly Ser Gly Val Ile Ala Ile Val Ile Ala Ala Val 225 230 235 240 Glu Met Asn Ser Arg Ala Ser Ile Gly Ala Glu Asp Arg Leu Thr Gly                 245 250 255 Ser Ala Phe Trp Gly Thr Ile Glu Val Leu Phe Thr Gly Val Ala Phe             260 265 270 Gly Leu Ile Gly Leu Asn Val Arg Ala Ala Ile Asp Glu Val Gly Ser         275 280 285 Glu Leu Trp His Ala Val Val Val Gly Ile Val Leu Ser Val Val Ala     290 295 300 Ile Val Val Arg Gly Val Trp Met Phe Ala Ala Tyr Lys Arg Asn Arg 305 310 315 320 Phe Lys Ile Asp Lys Lys Gly Ala Thr Asn Ser Ser Leu Arg Ala Pro                 325 330 335 Leu Arg Leu Gln Glu Ser Leu Leu Met Thr Trp Ala Gly Met Arg Gly             340 345 350 Leu Val Thr Leu Ala Leu Val Leu Ser Ile Pro Glu Asp Ile Phe Pro         355 360 365 Tyr His His Glu Leu Gln Val Ile Ala Leu Val Val Leu Leu Ile Thr     370 375 380 Met Val Gly Pro Gly Leu Thr Leu Pro Trp Leu Met Arg Lys Leu Ser 385 390 395 400 Leu Asp Lys Gly Pro Asp Ala Ala Gly Asp Glu Ser Ile Ala Ala Leu                 405 410 415 Thr Glu Arg Ala His Lys Ala Ala Thr Thr Tyr Leu Val Asp Thr Thr             420 425 430 Glu Leu Pro Met Glu Gln Met Val Ala Ile Lys Asn Trp Phe Ser Gln         435 440 445 Glu Ile Asp Ala Asp Glu Leu Gln Glu Asn Val Asp Lys Leu His Gln     450 455 460 Arg Ala His His Ala Arg Val Gly Ala Ile Lys Ala Ala Gln Glu Glu 465 470 475 480 Leu Leu Lys Ala Arg Arg Glu Arg Gly Val Asn Pro Ala Tyr Val Asp                 485 490 495 Glu Val Leu Thr Asn Ile Asp Arg Met Leu Val Ala Ala Glu Arg             500 505 510 <210> 669 <211> 993 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (970) <223> RXN03164 <400> 669 cttttttgca tccagatgca caaagccgtg gcacaaacga gacaaactga gcacaatggc 60 tgtcatggca tatcaaccag cagacaatcg ctatgacgac atg atc tac cgc agg 115                                             Met Ile Tyr Arg Arg                                               1 5 gtg gga aat tct ggg ctg aag ctt ccg gca att tcg ctt ggg ctg tgg 163 Val Gly Asn Ser Gly Leu Lys Leu Pro Ala Ile Ser Leu Gly Leu Trp                  10 15 20 cac aac ttc ggt gat gac aag ccg ctt tca acg cag cgc agc att att 211 His Asn Phe Gly Asp Asp Lys Pro Leu Ser Thr Gln Arg Ser Ile Ile              25 30 35 cac cgc gcg ttt gat agg gga gtc act cac ttc gat ttg gct aat aac 259 His Arg Ala Phe Asp Arg Gly Val Thr His Phe Asp Leu Ala Asn Asn          40 45 50 tat gga cct cca gca ggt tcc gca gag acc aac ttt ggc agg att ttg 307 Tyr Gly Pro Pro Ala Gly Ser Ala Glu Thr Asn Phe Gly Arg Ile Leu      55 60 65 cgt gag gat ctc aaa agc cac cgc gat gag ttg atc att tct tcc aag 355 Arg Glu Asp Leu Lys Ser His Arg Asp Glu Leu Ile Ile Ser Ser Lys  70 75 80 85 gcg ggt tgg gat atg tgg cct gga cct tat ggt ttt ggt ggt tcc cga 403 Ala Gly Trp Asp Met Trp Pro Gly Pro Tyr Gly Phe Gly Gly Ser Arg                  90 95 100 aag tat cta gtg agt tcc ctt gat cag tcc ctg act cgc ctc ggc ttg 451 Lys Tyr Leu Val Ser Ser Leu Asp Gln Ser Leu Thr Arg Leu Gly Leu             105 110 115 gat tac gtg gat att ttc tat cat cac cgc ccg gat cca gat act cct 499 Asp Tyr Val Asp Ile Phe Tyr His His Arg Pro Asp Pro Asp Thr Pro         120 125 130 ttg gaa gaa acc atg tac gca ttg cgt gac att gtt gcg tct gga aag 547 Leu Glu Glu Thr Met Tyr Ala Leu Arg Asp Ile Val Ala Ser Gly Lys     135 140 145 gct ctt tac gtg ggt att tct tcc tac ggt cca gag ctc aca gcg gag 595 Ala Leu Tyr Val Gly Ile Ser Ser Tyr Gly Pro Glu Leu Thr Ala Glu 150 155 160 165 gcg gct gag ttc atg gcg gag gag ggc tgc ccg ctt ctg att cat cag 643 Ala Ala Glu Phe Met Ala Glu Glu Gly Cys Pro Leu Leu Ile His Gln                 170 175 180 cca agc tat tcc atc att aat cgt tgg gtg gag gaa ccg ggc gat gac 691 Pro Ser Tyr Ser Ile Ile Asn Arg Trp Val Glu Glu Pro Gly Asp Asp             185 190 195 ggt gag aac ttg ttg cag tca gct gcc aac aat ggt ctt ggc gtc att 739 Gly Glu Asn Leu Leu Gln Ser Ala Ala Asn Asn Gly Leu Gly Val Ile         200 205 210 gct ttc tca cca ctt gcg cag ggc ctg ctc acg gac aaa tat ctc gat 787 Ala Phe Ser Pro Leu Ala Gln Gly Leu Leu Thr Asp Lys Tyr Leu Asp     215 220 225 gga att cca gag ggt tcc cgc gcc agc cag ggt aag tcc ctg tct gag 835 Gly Ile Pro Glu Gly Ser Arg Ala Ser Gln Gly Lys Ser Leu Ser Glu 230 235 240 245 ggc atg ttg aac gtg aac aat att gat atg gtc cgc aag ctc aat gac 883 Gly Met Leu Asn Val Asn Asn Ile Asp Met Val Arg Lys Leu Asn Asp                 250 255 260 atc gcc cag gaa cgc ggg cag tca ctt gcg cag atg gcg ctt gca tgg 931 Ile Ala Gln Glu Arg Gly Gln Ser Leu Ala Gln Met Ala Leu Ala Trp             265 270 275 gtg ctg cgc gag caa aga gag tac ggc gcc gga tta ccg tgaccagtgc 980 Val Leu Arg Glu Gln Arg Glu Tyr Gly Ala Gly Leu Pro         280 285 290 attgattggt gct 993 <210> 670 <211> 290 <212> PRT <213> Corynebacterium glutamicum <400> 670 Met Ile Tyr Arg Arg Val Gly Asn Ser Gly Leu Lys Leu Pro Ala Ile   1 5 10 15 Ser Leu Gly Leu Trp His Asn Phe Gly Asp Asp Lys Pro Leu Ser Thr              20 25 30 Gln Arg Ser Ile Ile His Arg Ala Phe Asp Arg Gly Val Thr His Phe          35 40 45 Asp Leu Ala Asn Asn Tyr Gly Pro Pro Ala Gly Ser Ala Glu Thr Asn      50 55 60 Phe Gly Arg Ile Leu Arg Glu Asp Leu Lys Ser His Arg Asp Glu Leu  65 70 75 80 Ile Ile Ser Ser Lys Ala Gly Trp Asp Met Trp Pro Gly Pro Tyr Gly                  85 90 95 Phe Gly Gly Ser Arg Lys Tyr Leu Val Ser Ser Leu Asp Gln Ser Leu             100 105 110 Thr Arg Leu Gly Leu Asp Tyr Val Asp Ile Phe Tyr His His Arg Pro         115 120 125 Asp Pro Asp Thr Pro Leu Glu Glu Thr Met Tyr Ala Leu Arg Asp Ile     130 135 140 Val Ala Ser Gly Lys Ala Leu Tyr Val Gly Ile Ser Ser Tyr Gly Pro 145 150 155 160 Glu Leu Thr Ala Glu Ala Ala Glu Phe Met Ala Glu Glu Gly Cys Pro                 165 170 175 Leu Leu Ile His Gln Pro Ser Tyr Ser Ile Ile Asn Arg Trp Val Glu             180 185 190 Glu Pro Gly Asp Asp Gly Glu Asn Leu Leu Gln Ser Ala Ala Asn Asn         195 200 205 Gly Leu Gly Val Ile Ala Phe Ser Pro Leu Ala Gln Gly Leu Leu Thr     210 215 220 Asp Lys Tyr Leu Asp Gly Ile Pro Glu Gly Ser Arg Ala Ser Gln Gly 225 230 235 240 Lys Ser Leu Ser Glu Gly Met Leu Asn Val Asn Asn Ile Asp Met Val                 245 250 255 Arg Lys Leu Asn Asp Ile Ala Gln Glu Arg Gly Gln Ser Leu Ala Gln             260 265 270 Met Ala Leu Ala Trp Val Leu Arg Glu Gln Arg Glu Tyr Gly Ala Gly         275 280 285 Leu pro     290 <210> 671 <211> 1068 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (1045) <223> RXN00024 <400> 671 ttaagacatc aacatatggc ttgtgctact gaaagatttt tcttctgaaa ttctgtagaa 60 acgctcctat gctcggggca gtaagttgtg agcataggaa atg gag cac ggc gtg 115                                             Met Glu His Gly Val                                               1 5 acc gtt att aaa ggc act gaa ttt gat gtt ttc cca cta aac ctc ggt 163 Thr Val Ile Lys Gly Thr Glu Phe Asp Val Phe Pro Leu Asn Leu Gly                  10 15 20 gga aat acc ttt ggc tgg acc tcg aat agg gaa cag acc ttc gcg gtt 211 Gly Asn Thr Phe Gly Trp Thr Ser Asn Arg Glu Gln Thr Phe Ala Val              25 30 35 ttg gat gca ttc gtg gca gcg gga gga aac ttt gtt gac acc gcc gat 259 Leu Asp Ala Phe Val Ala Ala Gly Gly Asn Phe Val Asp Thr Ala Asp          40 45 50 tct tat tct gca tgg gtt gaa ggc aat gag ggt ggc gag tcg gag cgg 307 Ser Tyr Ser Ala Trp Val Glu Gly Asn Glu Gly Gly Glu Ser Glu Arg      55 60 65 gag ctc ggc gcg tgg att aag gaa cgt ggc gca gac aag ctg atc att 355 Glu Leu Gly Ala Trp Ile Lys Glu Arg Gly Ala Asp Lys Leu Ile Ile  70 75 80 85 gct acc aag tct ggt gcg ttg gag cct gtt gct ggt cgt tcc cgt gag 403 Ala Thr Lys Ser Gly Ala Leu Glu Pro Val Ala Gly Arg Ser Arg Glu                  90 95 100 gca act ttc aag gct gtc gag ggt tcc ctg gag cgt ttg ggc gtg gaa 451 Ala Thr Phe Lys Ala Val Glu Gly Ser Leu Glu Arg Leu Gly Val Glu             105 110 115 tcg atc gat att ttt tac tac cac tac gac gat gag gca gtc agc att 499 Ser Ile Asp Ile Phe Tyr Tyr His Tyr Asp Asp Glu Ala Val Ser Ile         120 125 130 gat gag cag gtt gct atc gct aat gat ctg att gca cag ggc aag att 547 Asp Glu Gln Val Ala Ile Ala Asn Asp Leu Ile Ala Gln Gly Lys Ile     135 140 145 aag cac ctc gca ttg tct aac tac agc gcg gag cgt tta gct gag ttc 595 Lys His Leu Ala Leu Ser Asn Tyr Ser Ala Glu Arg Leu Ala Glu Phe 150 155 160 165 ttt gag aag tct gta ggc act cca gcg cag ccg gtt gct ctg caa ccg 643 Phe Glu Lys Ser Val Gly Thr Pro Ala Gln Pro Val Ala Leu Gln Pro                 170 175 180 cac tac aac ctg gtg tcg agg aag gat tat gag gag aac gtg cag cca 691 His Tyr Asn Leu Val Ser Arg Lys Asp Tyr Glu Glu Asn Val Gln Pro             185 190 195 ctc gcc gag aag cat ggc gtt gca gtc ttc cct tat ttc gcg ctt gcc 739 Leu Ala Glu Lys His Gly Val Ala Val Phe Pro Tyr Phe Ala Leu Ala         200 205 210 gcg ggt ctt ttg acc gga aag tac acc tcc aag gag gat att tcg ggt 787 Ala Gly Leu Leu Thr Gly Lys Tyr Thr Ser Lys Glu Asp Ile Ser Gly     215 220 225 aaa gcg cgt gcg ggg cag ttg gat cgt tac gcc agc gat gag gcg ttt 835 Lys Ala Arg Ala Gly Gln Leu Asp Arg Tyr Ala Ser Asp Glu Ala Phe 230 235 240 245 gcc gtg gtg aca gag ttg cgt gct gtt gcc gat gag ttg ggt gtt gcg 883 Ala Val Val Thr Glu Leu Arg Ala Val Ala Asp Glu Leu Gly Val Ala                 250 255 260 cca acg act gtg gcg ctt gcg tgg ttg gtt gcg cat ggt gtg acc gca 931 Pro Thr Thr Val Ala Leu Ala Trp Leu Val Ala His Gly Val Thr Ala             265 270 275 ccg att gcg tcc gtg tcc aag gta gag cag ttg aag gat ttg atg gct 979 Pro Ile Ala Ser Val Ser Lys Val Glu Gln Leu Lys Asp Leu Met Ala         280 285 290 gtg aag gat gtg gag ctg agc gct gag cag ctt gca cgt ttg gat aag 1027 Val Lys Asp Val Glu Leu Ser Ala Glu Gln Leu Ala Arg Leu Asp Lys     295 300 305 gtt tcg gag cct ttc gct taagctctcc tcaaaagtaa gtg 1068 Val Ser Glu Pro Phe Ala 310 315 <210> 672 <211> 315 <212> PRT <213> Corynebacterium glutamicum <400> 672 Met Glu His Gly Val Thr Val Ile Lys Gly Thr Glu Phe Asp Val Phe   1 5 10 15 Pro Leu Asn Leu Gly Gly Asn Thr Phe Gly Trp Thr Ser Asn Arg Glu              20 25 30 Gln Thr Phe Ala Val Leu Asp Ala Phe Val Ala Ala Gly Gly Asn Phe          35 40 45 Val Asp Thr Ala Asp Ser Tyr Ser Ala Trp Val Glu Gly Asn Glu Gly      50 55 60 Gly Glu Ser Glu Arg Glu Leu Gly Ala Trp Ile Lys Glu Arg Gly Ala  65 70 75 80 Asp Lys Leu Ile Ile Ala Thr Lys Ser Gly Ala Leu Glu Pro Val Ala                  85 90 95 Gly Arg Ser Arg Glu Ala Thr Phe Lys Ala Val Glu Gly Ser Leu Glu             100 105 110 Arg Leu Gly Val Glu Ser Ile Asp Ile Phe Tyr Tyr His Tyr Asp Asp         115 120 125 Glu Ala Val Ser Ile Asp Glu Gln Val Ala Ile Ala Asn Asp Leu Ile     130 135 140 Ala Gln Gly Lys Ile Lys His Leu Ala Leu Ser Asn Tyr Ser Ala Glu 145 150 155 160 Arg Leu Ala Glu Phe Phe Glu Lys Ser Val Gly Thr Pro Ala Gln Pro                 165 170 175 Val Ala Leu Gln Pro His Tyr Asn Leu Val Ser Arg Lys Asp Tyr Glu             180 185 190 Glu Asn Val Gln Pro Leu Ala Glu Lys His Gly Val Ala Val Phe Pro         195 200 205 Tyr Phe Ala Leu Ala Ala Gly Leu Leu Thr Gly Lys Tyr Thr Ser Lys     210 215 220 Glu Asp Ile Ser Gly Lys Ala Arg Ala Gly Gln Leu Asp Arg Tyr Ala 225 230 235 240 Ser Asp Glu Ala Phe Ala Val Val Thr Glu Leu Arg Ala Val Ala Asp                 245 250 255 Glu Leu Gly Val Ala Pro Thr Thr Val Ala Leu Ala Trp Leu Val Ala             260 265 270 His Gly Val Thr Ala Pro Ile Ala Ser Val Ser Lys Val Glu Gln Leu         275 280 285 Lys Asp Leu Met Ala Val Lys Asp Val Glu Leu Ser Ala Glu Gln Leu     290 295 300 Ala Arg Leu Asp Lys Val Ser Glu Pro Phe Ala 305 310 315 <210> 673 <211> 1758 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS (222) (101). (1735) <223> RXN01164 <400> 673 gccgatcgtg attgatgaag acgagatcca agcctggact tctgatctca aacctgaaga 60 tttcaccaaa ggtaaagatg aatccgacgg tgagaaataa gtg aca ctg ttt gtt 115                                             Val Thr Leu Phe Val                                               1 5 cgg ctc gcc ctt gct gct gtg ggc ggg ctt ttt gtc ttt gct tcc aat 163 Arg Leu Ala Leu Ala Ala Val Gly Gly Leu Phe Val Phe Ala Ser Asn                  10 15 20 gaa ccg atc ggc tgg ttt gtc gcg gga att gtt ggc act gca tta ttt 211 Glu Pro Ile Gly Trp Phe Val Ala Gly Ile Val Gly Thr Ala Leu Phe              25 30 35 ttt atc tcc ctt gcg ccg tgg gat ctg gga gtt ccc caa aag cgg cgg 259 Phe Ile Ser Leu Ala Pro Trp Asp Leu Gly Val Pro Gln Lys Arg Arg          40 45 50 aag aag aat gag cca gtc cca ttt ttg caa cag atg tcc acg ggc cca 307 Lys Lys Asn Glu Pro Val Pro Phe Leu Gln Gln Met Ser Thr Gly Pro      55 60 65 act gtt gta cag ggc atg ctt tta ggt ttt gtc cat ggc ctg gtg aca 355 Thr Val Val Gln Gly Met Leu Leu Gly Phe Val His Gly Leu Val Thr  70 75 80 85 tat ttg cag ctg ttg ccg tgg atc ggt gag ttt gtt ggc tca ctg cct 403 Tyr Leu Gln Leu Leu Pro Trp Ile Gly Glu Phe Val Gly Ser Leu Pro                  90 95 100 tat gtc gcg ttg tca gtt gtc gag gcg ctt tat tcc att gct ctt ggt 451 Tyr Val Ala Leu Ser Val Val Glu Ala Leu Tyr Ser Ile Ala Leu Gly             105 110 115 gct ttc ggc gtg ctc att gcg cgt tgg agg gac tgg aag gtt ctc ctg 499 Ala Phe Gly Val Leu Ile Ala Arg Trp Arg Asp Trp Lys Val Leu Leu         120 125 130 ttt ccg gcg atg tat gtg gct gtg gag tat cta aga agc tcg tgg cca 547 Phe Pro Ala Met Tyr Val Ala Val Glu Tyr Leu Arg Ser Ser Trp Pro     135 140 145 ttt gat gga ttc gcg tgg gtt cgc ctg gca tgg ggt caa att aac ggt 595 Phe Asp Gly Phe Ala Trp Val Arg Leu Ala Trp Gly Gln Ile Asn Gly 150 155 160 165 ccg ttg gct aat ctc gca gcg ctt ggt ggg gta gcg ttt gtc act ttt 643 Pro Leu Ala Asn Leu Ala Ala Leu Gly Gly Val Ala Phe Val Thr Phe                 170 175 180 tcc acg gtg ctg gct gcc gtg ggt gtg gcc atg gtg att att tcc aag 691 Ser Thr Val Leu Ala Ala Val Gly Val Ala Met Val Ile Ile Ser Lys             185 190 195 aag cga ctg gcc ggc gca atc atc acc gcg agt gtg att gct atc ggc 739 Lys Arg Leu Ala Gly Ala Ile Ile Thr Ala Ser Val Ile Ala Ile Gly         200 205 210 gcg gtg tca tcc ctg tac gtt gac cgc aat ggc acg agc gat gaa agc 787 Ala Val Ser Ser Leu Tyr Val Asp Arg Asn Gly Thr Ser Asp Glu Ser     215 220 225 atc gaa gta gcc gca att cag ggc aat gtg cct cgg atg gga ttg gac 835 Ile Glu Val Ala Ala Ile Gln Gly Asn Val Pro Arg Met Gly Leu Asp 230 235 240 245 ttc aat gca cag cgc cgc gcg gtg ctg gcg aat cac gca cgg gaa acc 883 Phe Asn Ala Gln Arg Arg Ala Val Leu Ala Asn His Ala Arg Glu Thr                 250 255 260 ctc aag ctg gat gaa caa gtg gat ttg gtg atc tgg ccg gag aat tcc 931 Leu Lys Leu Asp Glu Gln Val Asp Leu Val Ile Trp Pro Glu Asn Ser             265 270 275 tca gac gtc aac cca ttt tcc gat gca caa gca aga gcc att atc gat 979 Ser Asp Val Asn Pro Phe Ser Asp Ala Gln Ala Arg Ala Ile Ile Asp         280 285 290 gga gca gtg gaa cat gtt cag gca cct att ttg gtg ggc acg atc acc 1027 Gly Ala Val Glu His Val Gln Ala Pro Ile Leu Val Gly Thr Ile Thr     295 300 305 gtc gat gag gtt ggt cca cgc aac acc atg cag gta ttt gat cct gtt 1075 Val Asp Glu Val Gly Pro Arg Asn Thr Met Gln Val Phe Asp Pro Val 310 315 320 325 gaa ggt gcc gcg gag tac cac aat aag aag ttc ttg cag ccg ttt ggt 1123 Glu Gly Ala Ala Glu Tyr His Asn Lys Lys Phe Leu Gln Pro Phe Gly                 330 335 340 gaa tac atg ccg ttt cgc gaa ttc ctg aga att ttc tcg ccc tac gtt 1171 Glu Tyr Met Pro Phe Arg Glu Phe Leu Arg Ile Phe Ser Pro Tyr Val             345 350 355 gat tcc gct gga aac ttc cag ccc ggt gat ggc acc ggc gta gtg gag 1219 Asp Ser Ala Gly Asn Phe Gln Pro Gly Asp Gly Thr Gly Val Val Glu         360 365 370 atg aat gct gcg aac tta ggc cgc gct gtg aca gtg ggc gtg atg acg 1267 Met Asn Ala Ala Asn Leu Gly Arg Ala Val Thr Val Gly Val Met Thr     375 380 385 tgt tac gag gtc atc ttc gac cgt gct ggc cgc gac gcc atc gcc aat 1315 Cys Tyr Glu Val Ile Phe Asp Arg Ala Gly Arg Asp Ala Ile Ala Asn 390 395 400 405 ggg gct gaa ttt ttg acc acg ccc acc aac aac gcc acc ttc gga ttc 1363 Gly Ala Glu Phe Leu Thr Thr Pro Thr Asn Asn Ala Thr Phe Gly Phe                 410 415 420 acg gac atg acg tat cag caa tta gca atg agc agg atg cgt gcc atc 1411 Thr Asp Met Thr Tyr Gln Gln Leu Ala Met Ser Arg Met Arg Ala Ile             425 430 435 gaa ttt gat agg gcg gtg gtt gtt gca gct aca tcg ggt gtt tcg gct 1459 Glu Phe Asp Arg Ala Val Val Val Ala Ala Thr Ser Gly Val Ser Ala         440 445 450 atc gtc aac cct gat gga agc att tcc caa aac acc cga att ttt gag 1507 Ile Val Asn Pro Asp Gly Ser Ile Ser Gln Asn Thr Arg Ile Phe Glu     455 460 465 gcc gcc acc ttg acg gaa tcc att cca ctc aag gac act gtc acc atc 1555 Ala Ala Thr Leu Thr Glu Ser Ile Pro Leu Lys Asp Thr Val Thr Ile 470 475 480 485 gca gcg cgg gtt ggt ttc tat gtt gaa tta ctg ttg gtt atc att ggt 1603 Ala Ala Arg Val Gly Phe Tyr Val Glu Leu Leu Leu Val Ile Gly                 490 495 500 gta tta gct gga cta ttc gcc att cga atg aat agc cgt tca aag tct 1651 Val Leu Ala Gly Leu Phe Ala Ile Arg Met Asn Ser Arg Ser Lys Ser             505 510 515 gcg aaa ggt tcc gct cgg ccc gca caa gtt cgg gtt aag aag gtg cct 1699 Ala Lys Gly Ser Ala Arg Pro Ala Gln Val Arg Val Lys Lys Val Pro         520 525 530 gcg aaa aag gca gca act aat cgt cga aaa gta aaa taaaaacgtc 1745 Ala Lys Lys Ala Ala Thr Asn Arg Arg Lys Val Lys     535 540 545 ccgaagggac gag 1758 <210> 674 <211> 545 <212> PRT <213> Corynebacterium glutamicum <400> 674 Val Thr Leu Phe Val Arg Leu Ala Leu Ala Ala Val Gly Gly Leu Phe   1 5 10 15 Val Phe Ala Ser Asn Glu Pro Ile Gly Trp Phe Val Ala Gly Ile Val              20 25 30 Gly Thr Ala Leu Phe Phe Ile Ser Leu Ala Pro Trp Asp Leu Gly Val          35 40 45 Pro Gln Lys Arg Arg Lys Lys Asn Glu Pro Val Pro Phe Leu Gln Gln      50 55 60 Met Ser Thr Gly Pro Thr Val Val Gln Gly Met Leu Leu Gly Phe Val  65 70 75 80 His Gly Leu Val Thr Tyr Leu Gln Leu Leu Pro Trp Ile Gly Glu Phe                  85 90 95 Val Gly Ser Leu Pro Tyr Val Ala Leu Ser Val Val Glu Ala Leu Tyr             100 105 110 Ser Ile Ala Leu Gly Ala Phe Gly Val Leu Ile Ala Arg Trp Arg Asp         115 120 125 Trp Lys Val Leu Leu Phe Pro Ala Met Tyr Val Ala Val Glu Tyr Leu     130 135 140 Arg Ser Ser Trp Pro Phe Asp Gly Phe Ala Trp Val Arg Leu Ala Trp 145 150 155 160 Gly Gln Ile Asn Gly Pro Leu Ala Asn Leu Ala Ala Leu Gly Gly Val                 165 170 175 Ala Phe Val Thr Phe Ser Thr Val Leu Ala Ala Val Gly Val Ala Met             180 185 190 Val Ile Ile Ser Lys Lys Arg Leu Ala Gly Ala Ile Ile Thr Ala Ser         195 200 205 Val Ile Ala Ile Gly Ala Val Ser Ser Leu Tyr Val Asp Arg Asn Gly     210 215 220 Thr Ser Asp Glu Ser Ile Glu Val Ala Ala Ile Gln Gly Asn Val Pro 225 230 235 240 Arg Met Gly Leu Asp Phe Asn Ala Gln Arg Arg Ala Val Leu Ala Asn                 245 250 255 His Ala Arg Glu Thr Leu Lys Leu Asp Glu Gln Val Asp Leu Val Ile             260 265 270 Trp Pro Glu Asn Ser Ser Asp Val Asn Pro Phe Ser Asp Ala Gln Ala         275 280 285 Arg Ala Ile Ile Asp Gly Ala Val Glu His Val Gln Ala Pro Ile Leu     290 295 300 Val Gly Thr Ile Thr Val Asp Glu Val Gly Pro Arg Asn Thr Met Gln 305 310 315 320 Val Phe Asp Pro Val Glu Gly Ala Ala Glu Tyr His Asn Lys Lys Phe                 325 330 335 Leu Gln Pro Phe Gly Glu Tyr Met Pro Phe Arg Glu Phe Leu Arg Ile             340 345 350 Phe Ser Pro Tyr Val Asp Ser Ala Gly Asn Phe Gln Pro Gly Asp Gly         355 360 365 Thr Gly Val Val Glu Met Asn Ala Ala Asn Leu Gly Arg Ala Val Thr     370 375 380 Val Gly Val Met Thr Cys Tyr Glu Val Ile Phe Asp Arg Ala Gly Arg 385 390 395 400 Asp Ala Ile Ala Asn Gly Ala Glu Phe Leu Thr Thr Pro Thr Asn Asn                 405 410 415 Ala Thr Phe Gly Phe Thr Asp Met Thr Tyr Gln Gln Leu Ala Met Ser             420 425 430 Arg Met Arg Ala Ile Glu Phe Asp Arg Ala Val Val Val Ala Ala Thr         435 440 445 Ser Gly Val Ser Ala Ile Val Asn Pro Asp Gly Ser Ile Ser Gln Asn     450 455 460 Thr Arg Ile Phe Glu Ala Ala Thr Leu Thr Glu Ser Ile Pro Leu Lys 465 470 475 480 Asp Thr Val Thr Ile Ala Ala Arg Val Gly Phe Tyr Val Glu Leu Leu                 485 490 495 Leu Val Ile Ile Gly Val Leu Ala Gly Leu Phe Ala Ile Arg Met Asn             500 505 510 Ser Arg Ser Lys Ser Ala Lys Gly Ser Ala Arg Pro Ala Gln Val Arg         515 520 525 Val Lys Lys Val Pro Ala Lys Lys Ala Ala Thr Asn Arg Arg Lys Val     530 535 540 Lys 545 <210> 675 <211> 933 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101) .. (910) <223> RXN01168 <400> 675 ccgcacaagt tcgggttaag aaggtgcctg cgaaaaaggc agcaactaat cgtcgaaaag 60 taaaataaaa acgtcccgaa gggacgagga ggacaacacc atg agc agt gag gca 115                                             Met Ser Ser Glu Ala                                               1 5 gta gat gct acg acg ctg gtg att att cca acg tac aac gag ctg gaa 163 Val Asp Ala Thr Thr Leu Val Ile Ile Pro Thr Tyr Asn Glu Leu Glu                  10 15 20 aac ctt cca ctc atc gtg gat cgc gtg cgc acc gca acc cct gac gtt 211 Asn Leu Pro Leu Ile Val Asp Arg Val Arg Thr Ala Thr Pro Asp Val              25 30 35 cac gta ctc atc gtg gac gac aac agc cca gac ggc acc ggc gag cgc 259 His Val Leu Ile Val Asp Asp Asn Ser Pro Asp Gly Thr Gly Glu Arg          40 45 50 gca gac aag ctt gct gct gac gac gac cac att ttt gtc ctc cac cgc 307 Ala Asp Lys Leu Ala Ala Asp Asp Asp His Ile Phe Val Leu His Arg      55 60 65 gaa ggc aaa ggc ggc ctg tgc gca gag tac atg gct ggc ttc cag tgg 355 Glu Gly Lys Gly Gly Leu Cys Ala Glu Tyr Met Ala Gly Phe Gln Trp  70 75 80 85 ggc ctg gag cgc gac tac cag gtc ctg tgc gaa atg gac gcc gac ggc 403 Gly Leu Glu Arg Asp Tyr Gln Val Leu Cys Glu Met Asp Ala Asp Gly                  90 95 100 tcc cac gca cca gaa cag ctg cac ctg ctg ctc gct gag atc acc aat 451 Ser His Ala Pro Glu Gln Leu His Leu Leu Leu Ala Glu Ile Thr Asn             105 110 115 ggc gct gac ctg gtc atc ggc tcg cgc tac gtg cca ggc ggc cgc gta 499 Gly Ala Asp Leu Val Ile Gly Ser Arg Tyr Val Pro Gly Gly Arg Val         120 125 130 gtc aac tgg ccc aag aac cgt tgg ctc ttg tcc aag ggc ggc aac gtc 547 Val Asn Trp Pro Lys Asn Arg Trp Leu Leu Ser Lys Gly Gly Asn Val     135 140 145 tac atc agc gtc gcg ctc ggc gcc ggc ttg acc gat atg acc gca ggg 595 Tyr Ile Ser Val Ala Leu Gly Ala Gly Leu Thr Asp Met Thr Ala Gly 150 155 160 165 tac cgc gct ttt cga cgt gaa gtg cta gaa gca ctg ccg ctt gat gag 643 Tyr Arg Ala Phe Arg Arg Glu Val Leu Glu Ala Leu Pro Leu Asp Glu                 170 175 180 ctc tcc aac gct ggg tac att ttc caa gtt gag att gcc tac cgt gca 691 Leu Ser Asn Ala Gly Tyr Ile Phe Gln Val Glu Ile Ala Tyr Arg Ala             185 190 195 gtt gaa gcc gga ttc gat gtt cgt gaa gtt ccc atc act ttc acc gag 739 Val Glu Ala Gly Phe Asp Val Arg Glu Val Pro Ile Thr Phe Thr Glu         200 205 210 cgt gag atc ggc gaa tcc aag ctg gac ggc agc ttt gtc aag gat tcc 787 Arg Glu Ile Gly Glu Ser Lys Leu Asp Gly Ser Phe Val Lys Asp Ser     215 220 225 ctg ctc gag gta acc aag tgg ggc ctc aag cac cgc ggt ggc cag gcc 835 Leu Leu Glu Val Thr Lys Trp Gly Leu Lys His Arg Gly Gly Gln Ala 230 235 240 245 aag gaa ctg tcc aag gaa atg gtc ggc ctg ctg aac tat gag tgg aag 883 Lys Glu Leu Ser Lys Glu Met Val Gly Leu Leu Asn Tyr Glu Trp Lys                 250 255 260 cac ttc aaa aag cgc aac acc tgg ctc taaactgctt gccggttagt 930 His Phe Lys Lys Arg Asn Thr Trp Leu             265 270 gaa 933 <210> 676 <211> 270 <212> PRT <213> Corynebacterium glutamicum <400> 676 Met Ser Ser Glu Ala Val Asp Ala Thr Thr Leu Val Ile Ile Pro Thr   1 5 10 15 Tyr Asn Glu Leu Glu Asn Leu Pro Leu Ile Val Asp Arg Val Arg Thr              20 25 30 Ala Thr Pro Asp Val His Val Leu Ile Val Asp Asp Asn Ser Pro Asp          35 40 45 Gly Thr Gly Glu Arg Ala Asp Lys Leu Ala Ala Asp Asp Asp His Ile      50 55 60 Phe Val Leu His Arg Glu Gly Lys Gly Gly Leu Cys Ala Glu Tyr Met  65 70 75 80 Ala Gly Phe Gln Trp Gly Leu Glu Arg Asp Tyr Gln Val Leu Cys Glu                  85 90 95 Met Asp Ala Asp Gly Ser His Ala Pro Glu Gln Leu His Leu Leu Leu             100 105 110 Ala Glu Ile Thr Asn Gly Ala Asp Leu Val Ile Gly Ser Arg Tyr Val         115 120 125 Pro Gly Gly Arg Val Val Asn Trp Pro Lys Asn Arg Trp Leu Leu Ser     130 135 140 Lys Gly Gly Asn Val Tyr Ile Ser Val Ala Leu Gly Ala Gly Leu Thr 145 150 155 160 Asp Met Thr Ala Gly Tyr Arg Ala Phe Arg Arg Glu Val Leu Glu Ala                 165 170 175 Leu Pro Leu Asp Glu Leu Ser Asn Ala Gly Tyr Ile Phe Gln Val Glu             180 185 190 Ile Ala Tyr Arg Ala Val Glu Ala Gly Phe Asp Val Arg Glu Val Pro         195 200 205 Ile Thr Phe Thr Glu Arg Glu Ile Gly Glu Ser Lys Leu Asp Gly Ser     210 215 220 Phe Val Lys Asp Ser Leu Leu Glu Val Thr Lys Trp Gly Leu Lys His 225 230 235 240 Arg Gly Gly Gln Ala Lys Glu Leu Ser Lys Glu Met Val Gly Leu Leu                 245 250 255 Asn Tyr Glu Trp Lys His Phe Lys Lys Arg Asn Thr Trp Leu             260 265 270 <210> 677 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: primer <400> 677 ggaaacagta tgaccatg 18 <210> 678 <211> 17 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: primer <400> 678 gtaaaacgac ggccagt 17

Claims (45)

delete delete Isolated nucleic acid molecule or complement thereof having a nucleotide sequence set forth in SEQ ID NO: 5. An isolated nucleic acid molecule or complement thereof encoding a polypeptide having an amino acid sequence set forth in SEQ ID NO: 6. delete An isolated nucleic acid molecule or complement thereof having a nucleotide sequence set forth in SEQ ID NO: 5 or a variant thereof due to the degeneracy of the genetic code and encoding a polypeptide having cysQ activity. delete An isolated nucleic acid molecule or complement thereof encoding a polypeptide having an amino acid sequence comprising conservative amino acid substitutions in the amino acid sequence set forth in SEQ ID NO: 6. delete A vector comprising the nucleic acid molecule of any one of claims 3, 4, 6 and 8. The vector of claim 10 which is an expression vector. A host cell transfected with the expression vector of claim 11. The host cell of claim 12, wherein said cell is a microorganism. The host cell of claim 13, wherein the cell is included in Corynebacterium or Brevibacterium . The method of claim 12, wherein the expression of the nucleic acid molecule causes organic acids, proteinogenic amino acids, non-proteinogenic amino acids, purine and pyrimidine bases, nucleosides, nucleotides, lipids, saturated and unsaturated fatty acids, diols, A host cell in which the production of a substance selected from the group consisting of carbohydrates, aromatic compounds, vitamins, cofactors, polyketides and enzymes is regulated. The host cell of claim 15, wherein said substance is a proteinogenic amino acid. A method of producing a polypeptide comprising producing the polypeptide by culturing the host cell of claim 12 in a suitable culture medium. delete delete An isolated polypeptide having the amino acid sequence set forth in SEQ ID NO: 6. delete delete An isolated polypeptide encoded with a nucleic acid molecule having a nucleotide sequence set forth in SEQ ID NO: 5 or a variant thereof due to the degeneracy of the genetic code and having cysQ activity. delete The cell of claim 12 wherein the cell comprises an organic acid, a proteinogenic amino acid, a non-proteinogenic amino acid, a purine and pyrimidine base, a nucleoside, a nucleotide, a lipid, a saturated and unsaturated fatty acid, a diol, a carbohydrate, an aromatic compound, a vitamin, a cofactor, a polyke Culturing the cells to produce a material selected from the group consisting of a Tid and an enzyme. The method of claim 25 further comprising recovering the material from the culture. delete The method of claim 25, wherein said cells are included in Corynebacterium or Brevibacterium. The method of claim 25, wherein the cells are Corynebacterium glutamicum , Corynebacterium herculis , Corynebacterium lilium , Corynebacterium acetoacy dopil room (Corynebacterium acetoacidophilum), Corynebacterium acetonitrile glutamicum (Corynebacterium acetoglutamicum), Corynebacterium acetonitrile pilrum (Corynebacterium acetophilum), Corynebacterium ammoniagenes to Ness (Corynebacterium ammoniagenes), Corynebacterium Fujio kense ( Corynebacterium fujiokense), Corynebacterium acrylonitrile peel Ruth (Corynebacterium nitrilophilus), Brevibacterium ammonia to Ness (Brevibacterium ammoniagenes), Brevibacterium portion Tani glutamicum (Brevibacterium butanicum), Brevibacterium diva Rica Tomb (Brevibacterium divaricatum), Brevibacterium Playa boom (Brevibacterium flavum), Brevibacterium Alriyi (Brevibacterium healii), Brevibacterium keto glutamicum (Brevibacterium ketoglutamicum), Brevibacterium keto sore deoktum (Brevibacterium ketosoreductum), Brevibacterium lactofermentum (Brevibacterium lactofermentum), Brevibacterium linens Scotland ( Brevibacterium linens ), Brevibacterium paraffinolyticum , and the strains listed in Table 3. The method of claim 25, wherein the production of said substance is regulated by the expression of nucleic acid molecules from said vector. The method of claim 25, wherein said substance is a proteinogenic amino acid. The method of claim 25, wherein the substance is a non-proteinogenic amino acid. The method of claim 25, wherein the amino acids are lysine, glutamate, glutamine, alanine, aspartate, glycine, serine, threonine, methionine, cysteine, valine, leucine, isoleucine, arginine, proline, histidine, tyrosine, phenylalanine and The method selected from the group consisting of tryptophan. A method of producing a substance comprising culturing an altered cell in which the genomic DNA of the cell comprises the nucleic acid molecule of any one of claims 3, 4, 6 and 8. delete A host cell comprising a nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO: 5, wherein the nucleic acid molecule is disrupted. delete delete delete An isolated polypeptide encoded by a nucleic acid molecule having the nucleotide sequence of SEQ ID NO: 5. delete An isolated polypeptide having an amino acid sequence comprising conservative amino acid substitutions in the amino acid sequence set forth in SEQ ID NO: 6. delete delete delete