CN1371417A - Corynebacterium glutamicum genes encoding proteins involved in carbon metabolism - Google Patents

Abstract

Isolated nucleic acid molecules, designated MP nucleic acid molecules, which encode novel MP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MP proteins, mutated MP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MP genes in this organism.

Description

Corynebacterium glutamicum genes encoding metabolic pathway proteins

RELATED APPLICATIONS

This application claims priority from: previously filed U.S. provisional application serial No. 60/141031, filed on 25.6.1999, U.S. provisional application serial No. 60/142101, filed on 2.7.1999, U.S. provisional application serial No. 60/148613, filed on 12.8.1999, and U.S. provisional application serial No. 60/187970, filed on 9.3.2000. The present application also claims priority from: in the previously filed German patent application No. 19930476.9, application date July1, 1999, German patent application No. 19931415.2, application date 1999 of 7.8.d, German patent application No. 19931418.7, application date 1999 of 7.8.d, German patent application No. 19931419.5, application date 1999 of 7.8.d, German patent application No. 19931420.9, application date 1999 of 7.8.d, German patent application No. 19931424.1, application date 1999 of 7.8.d, German patent application No. 19931428.4, application date 1999 of 7.8.d, German patent application No. 19931434.9, application date 1999 of 7.8.d, German patent application No. 19931435.7, application date 1999 of 7.8.d, German patent application No. 19931443.8, application date 1999 of 7.8.d, German patent application No. 19931453.5, application date 1999 of 7.8.d, German patent application No. 19931457.8, application date 1999 of 7.8.d, German patent application No. 19931465.9, application date 1999 of 7.8.8.d, German patent application No. 19931478.0, on 8 th 7 th 1999, german patent application No. 19931510.8, on 8 th 7 th 1999, german patent application No. 19931541.8, on 8 th 7 th 1999, german patent application No. 19931573.6, on 8 th 7 th 1999, german patent application No. 19931592.2, on 8 th 7 th 1999, german patent application No. 19931632.5, on 8 th 7 th 1999, german patent application No. 19931634.1, on 8 th 7 th 1999, german patent application No. 19931636.8, on 8 th 1999, german patent application No. 19932125.6, on 9 th 7 th 1999, german patent application No. 19932126.4, on 9 th 7 th 1999, german patent application No. 19932130.2, on 9 th 1999, german patent application No. 19932186.8, on 9 th 1999, on 9 th 7 th 9 th 1999, german patent application No. 19932206.6, on 399 th 1999, on 19932227.9, on 7 th 1999, german patent application No. 19932228.7, application date 1999 of 7.9 days, German patent application No. 19932229.5, application date 1999 of 7.9 days, German patent application No. 19932230.9, application date 1999 of 7.9 days, German patent application No. 19932922.2, application date 1999 of 7.14 days, German patent application No. 19932926.5, application date 1999 of 7.14 days, German patent application No. 19932928.1, application date July14, 1999, German patent application No. 19933004.2, application date 1999 of 7.14 days, German patent application No. 19933005.0, application date 1999 of 7.14 days, German patent application No. 19933006.9, application date 1999 of 7.14 days, German patent application No. 19940764.9, application date 1999 of 8.27 days, German patent application No. 19940765.7, application date 1999 of 8.27 days, German patent application No. 19940766.5, application date 1999 of 8.27 days, German patent application No. 19940832.7, application date 1999 of 8.27 days, German patent application No. 19941378.9, application date 1999 of 8.31 days, german patent application No. 19941379.7, application date 1999 8.31, german patent application No. 19941380.0, application date 1999 8.31, german patent application No. 19941394.0, application date 1999 8.31, german patent application No. 19941396.7, application date 1999 8.31, german patent application No. 19942076.9, application date 1999 9.3, german patent application No. 19942077.7, application date 1999 9.3, german patent application No. 19942079.3, application date 1999 9.3, german patent application No. 19942086.6, application date 1999 9.3, german patent application No. 19942087.4, application date 1999 9.3, german patent application No. 19942088.2, application date 1999 9.3, german patent application No. 19942095.5, application date 1999 9.3, german patent application No. 19942124.2, application date 1999 9.3, and german patent application No. 19942129.3, 1999 9.3. The entire contents of the above application are incorporated herein by reference.

Background

Certain products and by-products of metabolic processes occurring naturally in cells have utility in a number of industries, including the food, feed, cosmetic and pharmaceutical industries. These molecules, collectively referred to as "fine chemicals", include organic acids, proteinogenic and nonproteinogenic amino acids, nucleotides and nucleosides, lipids and fatty acids, diols, sugars, aromatic compounds, vitamins and cofactors, and enzymes. These products can be most conveniently prepared by large scale culture of bacteria that produce and secrete large quantities of the particular desired molecule. One particularly useful organism for this purpose is Corynebacterium glutamicum (Corynebacterium glutamicum), a gram-positive non-pathogenic bacterium. Through strain screening, a number of mutant strains have emerged that produce large quantities of the desired compound. However, strain screening to improve the production of a particular molecule is a time consuming and difficult process.

Summary of The Invention

The present invention provides novel bacterial nucleic acid molecules that have a variety of uses. These include the identification of microorganisms which produce fine chemicals, the regulation of the production of fine chemicals in C.glutamicum or related bacteria, the typing and identification of C.glutamicum or related bacteria, as reference points for the mapping of C.glutamicum genomes. These novel nucleic acid molecules encode proteins, referred to herein as Metabolic Pathway (MP) proteins.

Corynebacterium glutamicum is a gram-positive aerobic bacterium which is commonly used in industry for the large-scale production of various fine chemicals, and also for the degradation of hydrocarbons (for example in oil spills) and the oxidation of terpineol. Thus, the MP nucleic acid molecules of the invention may be used to identify microorganisms that can be used to produce fine chemicals, for example, by fermentation methods. Modulation of the expression of the MP nucleic acid molecules of the invention, or modification of the sequence of the MP nucleic acid molecules of the invention, may be used to modulate the production of one or more fine chemicals in a microorganism (e.g., to increase the production of one or more fine chemicals in a coryneform bacterium or Brevibacterium).

The MP nucleic acid molecules of the invention can be used to identify whether a microorganism is Corynebacterium glutamicum or a related strain thereof, or to identify the presence of Corynebacterium glutamicum or a related strain thereof in a mixed population of microorganisms. The present invention provides nucleic acid sequences of a plurality of genes of Corynebacterium glutamicum; the presence of a microorganism can be determined by probing, under stringent conditions, genomic DNA extracted from a culture of a single microorganism or a mixed population of microorganisms with a probe covering a region characteristic of the gene of Corynebacterium glutamicum. Although Corynebacterium glutamicum itself is nonpathogenic, it is associated with pathogenic species in humans, such as Corynebacterium diphtheriae (diphtheria pathogen); detection of such microorganisms has significant clinical utility.

The MP nucleic acid molecules of the invention may also be used as reference points for mapping the genome of C.glutamicum, or for mapping the genome of a related strain thereof. Similarly, these molecules, or variants or portions thereof, can be used as genetic markers for genetically engineered corynebacterium or brevibacterium. For example, the MP proteins encoded by the novel nucleic acid molecules of the invention may be subjected to enzymatic steps in the metabolism of certain fine chemicals, including amino acids, vitamins, cofactors, trophic factors (nutraceuticals), nucleotides, nucleosides, and trehalose. In view of the utility of cloning vectors which can be used in Corynebacterium glutamicum, as disclosed, for example, in Sinskey et al, U.S. Pat. No.4,649,119, and in view of the genetic manipulation techniques of Corynebacterium glutamicum and Brevibacterium relatives species (e.g.Brevibacterium lactofermentum) (Yashihama et al, J.Bacteriol.162: 591-597 (1985); Katsumata et al, J.Bacteriol.159: 306-311 (1984); and Santamara et al, J.Gen.Microbiol.130: 2237-2246(1984)), the nucleic acid molecules of the invention can be used for the genetic engineering of this organism to make it a better or more efficient producer of one or more fine chemical substances.

The enhanced or efficient production of a fine chemical may be a direct effect of the genetic manipulation of the invention or an indirect effect of such genetic manipulation. In particular, alterations in the amino acid, vitamin, cofactor, nucleotide and trehalose metabolic pathways of C.glutamicum have a direct effect on the production of one or more of these desired compounds by this organism. For example, optimizing lysine biosynthetic pathway protein activity or decreasing lysine degradation pathway protein activity can result in increased yield or efficiency of lysine production from such engineered organisms. Alterations in these metabolic pathway proteins may also have an indirect effect on the production or efficiency of the desired fine chemical. For example, reactions that compete with intermediates necessary to produce the desired molecule can be eliminated, or the pathways necessary to produce a particular intermediate of the desired compound can be optimized. Furthermore, the regulation of the biosynthesis or degradation of amino acids, vitamins or nucleotides can increase the capacity for production and division, thus increasing the number and/or productivity of the microorganisms in culture and increasing the possible yield of the desired fine chemical.

The nucleic acid and protein molecules of the invention can be used to directly increase the production or efficiency of production of one or more desired fine chemicals in C.glutamicum. Using recombinant techniques known in the art, one or more of the biosynthetic or degradative enzymes of amino acids, vitamins, cofactors, trophic factors, nucleotides, nucleosides, or trehalose of the invention can be altered, thereby modulating its function. For example, the efficiency of a biosynthetic enzyme may be increased, or its allosteric control region disrupted to prevent feedback inhibition of compound production. Similarly, the degrading enzyme may be deleted or modified by substitution, deletion or addition such that its degrading activity towards the desired compound is reduced without affecting the viability of the cell. In each case, the overall yield or productivity of the desired fine chemical is increased.

Alterations of the protein and nucleotide molecules of the invention may also enhance the production of other fine chemicals than amino acids, vitamins, cofactors, trophic factors, nucleotides, nucleosides, or trehalose by indirect mechanisms. The metabolism of any one compound is necessarily linked to other biosynthetic and degradation pathways within the cell, and the necessary cofactors, intermediates or substrates in one pathway may be supplied by or limited by other pathways of the same kind. Thus, by adjusting the activity of one or more proteins of the invention, the production or efficiency of the activity of another fine chemical biosynthetic or degradation pathway may be influenced. For example, amino acids may serve as building blocks for all proteins, but their presence in the cell at levels that may limit protein synthesis; thus, by increasing the efficiency or yield of production of one or more amino acids within a cell, proteins such as biosynthetic or degradative proteins can be more easily synthesized. Likewise, where alterations in metabolic pathway enzymes make particular side reactions more favorable or unfavorable, they may result in over-production or under-production of one or more compounds that are useful as intermediates or substrates for the production of a desired fine chemical.

The present invention provides novel nucleic acid molecules encoding proteins, referred to herein as Metabolic Pathway (MP) proteins, which are capable of performing enzymatic steps in the metabolism of molecules important to the normal function of a cell, such as amino acids, vitamins, cofactors, nucleotides and nucleotides, or trehalose. Nucleic acid molecules encoding MP proteins are referred to herein as MP nucleic acid molecules. In a preferred embodiment, the MP protein performs an enzymatic step associated with the metabolism of one or more of the following: amino acids, vitamins, cofactors, trophic factors, nucleotides, nucleosides, and trehalose. Examples of such proteins include those encoded by the genes listed in Table 1.

Accordingly, one aspect of the invention relates to the isolation of nucleic acid molecules (e.g., cDNA, DNA, or RNA) comprising a nucleic acid sequence encoding an MP protein or a biologically active portion thereof, and the isolation of nucleic acid fragments suitable as primers or hybridization probes for the detection or amplification of MP-encoding nucleic acids (e.g., DNA or RNA). In particularly preferred embodiments, the isolated nucleic acid molecule comprises a nucleic acid sequence set forth as an odd-numbered sequence in the sequence listing (e.g., SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 7.) or a coding region of such a nucleotide sequence or the complement thereof. In other particularly preferred embodiments, the isolated nucleic acid molecule of the invention comprises at least about 50% homology, preferably at least about 60% homology, more preferably at least about 70%, 80%, or 90% homology, even more preferably at least about 95%, 96%, 97%, 98%, 99% or more homology to a nucleotide sequence having an odd number of sequence numbers in the sequence listing (e.g., SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 7.) or portion thereof. In other preferred embodiments, the isolated nucleic acid molecule encodes an even-numbered sequence of amino acids as set forth in the sequence Listing (e.g., SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 8.). Preferred MP proteins of the invention also preferably have at least one MP activity as described herein.

In another embodiment, an isolated nucleic acid molecule encodes a protein or portion thereof, wherein the protein or portion thereof comprises an amino acid sequence that is sufficiently homologous to an amino acid sequence of the invention (e.g., a sequence having an even-numbered sequence number in the sequence listing), e.g., sufficient homologous to an amino acid sequence of the invention such that the protein or portion thereof has MP activity. Preferably, the protein encoded by the nucleic acid molecule, or a portion thereof, retains the ability to undergo enzymatic reactions in amino acid, vitamin, cofactor, nucleotide and nucleotide or trehalose metabolic pathways. In one embodiment, the nucleic acid molecule encodes a protein that is at least about 50% homologous, preferably at least about 60% homologous, more preferably at least about 70%, 80%, 90% homologous, and most preferably at least about 95%, 96%, 97%, 98%, 99% or more homologous to an amino acid sequence of the invention (e.g., the entire amino acid sequence selected from the even-numbered sequence numbers in the sequence listing). In another preferred embodiment, the protein is a full-length C.glutamicum protein which is substantially homologous to the full-length amino acid sequence of the present invention encoded by the open reading frame of the odd-numbered nucleic acid sequence shown in the corresponding sequence listing (e.g., SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 7.).

In another preferred embodiment, the isolated nucleic acid molecule is from Corynebacterium glutamicum and encodes a protein (e.g., an MP fusion protein) that comprises a biologically active region that is at least about 50% or more homologous to an amino acid sequence of the present invention (e.g., a sequence set forth in an even-numbered sequence of the sequence listing), and that catalyzes a reaction in an amino acid, vitamin, cofactor, nucleotide, and nucleotide or trehalose metabolic pathway, or possesses one or more of the activities listed in Table 1, and that further comprises a heterologous nucleic acid sequence encoding a heterologous polypeptide or regulatory region.

In another embodiment, an isolated nucleic acid molecule is at least 15 nucleotides in length and hybridizes under stringent conditions to a nucleic acid molecule comprising a nucleotide sequence of the invention (e.g., a sequence having an odd number in the sequence listing). Preferably, the isolated nucleic acid molecule is identical to a naturally occurring nucleic acid molecule. More preferably, the isolated nucleic acid molecule encodes a naturally occurring MP protein from Corynebacterium glutamicum, or a biologically active portion thereof.

Another aspect of the invention relates to the use of vectors, e.g., recombinant expression vectors, comprising a nucleic acid molecule of the invention, and host cells into which such vectors have been introduced. In one embodiment, such host cells are used to produce MP protein by culturing in a suitable medium. The MP protein may then be isolated from the culture medium or the host cell.

In addition, another aspect of the present invention relates to a genetically altered microorganism into which an MP gene has been introduced or has been altered. In one embodiment, the genome of the microorganism is altered by introducing as a transgene a nucleic acid molecule of the invention encoding a wild-type or mutant MP sequence. In another embodiment, the endogenous MP gene in the genome of the microorganism is altered, e.g., functionally disrupted by homologous recombination using the altered MP gene. In another embodiment, the endogenous or introduced MP gene in the microorganism is altered by one or more point mutations, deletions or inversions, but still encodes a functional MP protein. In another embodiment, one or more regulatory regions (e.g., promoter, repressor, or inducer) of a microbial MP gene are altered, thereby regulating the expression of the MP gene. In a preferred embodiment, the microorganism belongs to the species Corynebacterium or Brevibacterium, particularly preferably Corynebacterium glutamicum. In a preferred embodiment, the microorganisms are also used for the production of the desired compounds, for example amino acids, particularly preferably lysine.

In another aspect, the invention provides a method of identifying the presence or activity of corynebacterium diphtheriae in a subject. The method includes detection of one or more nucleic acid or amino acid sequences of the invention (e.g., the sequences set forth in SEQ ID NOs 1 to 1156 of the sequence listing) in a subject, such that the presence or activity of corynebacterium glutamicum in the subject can be detected.

In addition, another aspect of the invention relates to MP proteins that have been isolated or a portion thereof, such as a biologically active portion thereof. In a preferred embodiment, the isolated MP protein or a portion thereof may catalyze an enzymatic reaction in one or more pathways of amino acid, vitamin, cofactor, trophic factor, nucleotide, nucleoside, or trehalose metabolism. In another preferred embodiment, the isolated MP protein or portion thereof has sufficiently high homology to an amino acid sequence of the present invention (e.g., a sequence set forth as an even-numbered sequence in the sequence listing) that the protein or portion thereof retains the ability to catalyze an enzymatic reaction in one or more pathways of amino acid, vitamin, cofactor, trophic factor, nucleotide, nucleoside, or trehalose metabolism.

The invention also provides isolated preparations of MP proteins. In a preferred embodiment, the MP protein comprises an amino acid sequence of the invention (e.g., one of the even-numbered seq id nos of the sequence listing). In another preferred embodiment, the invention relates to an isolated full-length protein having substantial homology to the complete amino acid sequence of the invention (one of the even-numbered sequence numbers of the sequence listing) encoded by the open reading frame indicated as being odd-numbered in the corresponding sequence listing. In addition, in another embodiment, the protein is at least about 50% homologous, preferably at least about 60% homologous, more preferably at least about 70%, 80%, or 90% homologous, and most preferably at least about 95%, 96%, 97%, 98%, or 99% or more homologous to a complete amino acid sequence of the invention (e.g., an even-numbered sequence number sequence in the sequence listing). In another embodiment, an isolated MP protein comprises an amino acid sequence that is at least about 50% or more homologous to an amino acid sequence of the present invention (e.g., an even-numbered sequence number sequence in the sequence listing) and is capable of catalyzing an enzymatic reaction in an amino acid, vitamin, cofactor, trophic factor, nucleotide, nucleoside, or trehalose metabolic pathway, or has one or more activities listed in table 1.

Alternatively, an isolated MP protein may comprise an amino acid sequence encoded by a nucleic acid sequence that hybridizes, e.g., under stringent conditions, to a nucleic acid sequence having an even-numbered sequence number as set forth in the sequence listing, or that is at least about 50% homologous, preferably at least about 60% homologous, more preferably at least about 70%, 80%, or 90% homologous, and even more preferably at least about 95%, 96%, 97%, 98%, or 99% or more homologous to the nucleic acid sequence. Preferred forms of the MP protein also have one or more of the biological activities described herein, and are also preferred.

The MP polypeptide, or biologically active portion thereof, may be operatively linked to a non-MP polypeptide to form a fusion protein. In a preferred embodiment, the fusion protein has an activity different from the MP protein alone. In a further preferred embodiment, the fusion protein, when introduced into the amino acid, vitamin, cofactor, trophic factor metabolic pathway of Corynebacterium glutamicum, leads to an increase in the production, production and/or efficiency of production of the desired fine chemical in Corynebacterium glutamicum. In particularly preferred embodiments, the fusion protein is incorporated into an amino acid, microbial, cofactor, trophic factor, nucleotide, nucleoside, or trehalose metabolic pathway of a host cell that regulates the production of a desired compound in the cell.

In another aspect, the invention provides methods of screening for molecules that modulate the activity of MP proteins. The molecule modulates MP protein activity by interacting with the protein molecule itself or a substrate, or binding to a partner of the MP protein, or by modulating transcription or translation of the MP nucleic acid molecule of the invention.

Another aspect of the invention relates to a method for producing fine chemicals. The method involves culturing a cell containing a vector that directs the expression of the MP nucleic acid molecules of the invention, thereby producing the fine chemical. In a preferred embodiment, the method further comprises the step of obtaining a cell containing the vector, wherein the cell is transfected with a vector that directs the expression of the MP nucleic acid molecule. In another preferred embodiment, the method further comprises the step of recovering the fine chemical from the culture medium. In a particularly preferred embodiment, the cell is a corynebacterium species or a brevibacterium species, or is selected from those strains listed in table 3.

Another aspect of the invention relates to a method of modulating the production of a molecule in a microorganism. Such methods comprise contacting a cell with an agent that modulates the activity of an MP protein or the expression of an MP nucleic acid, such that the activity associated with the cell is alteredrelative to the activity in the absence of the agent. In a preferred embodiment, the metabolic pathways of one or more amino acids, vitamins, cofactors, trophic factors, nucleotides, nucleosides or trehalose of the C.glutamicum cell are modulated such that the yield or efficiency of production of a desired fine chemical by this microorganism is increased. The agent that modulates MP protein activity may be an agent that stimulates MP protein activity or MP nucleic acid expression. Examples of agents that stimulate MP protein activity or MP nucleic acid expression include small molecules, active MP proteins, and nucleic acids encoding MP proteins that have been introduced into a cell. Examples of agents that inhibit the activity or expression of an MP protein include small molecules and antisense MP nucleic acid molecules.

In another aspect, the invention relates to a method of modulating the production of a desired compound in a cell comprising introducing into the cell a wild type or mutant MP gene, either maintained on a separate plasmid or integrated into the host cell genome. If integrated into the host cell genome, such integration can be arbitrary or can occur by homologous recombination such that the introduced copies replace the native gene, resulting in modulated production of the desired compound in the cell. In a preferred embodiment, the yield is increased. In another preferred embodiment, the fine chemical is an amino acid. In a particularly preferred embodiment, the amino acid is L-lysine.

Detailed Description

The present invention provides MP nucleic acid and protein molecules which are involved in the metabolism of certain fine chemicals including amino acids, vitamins, cofactors, trophic factors, nucleotides, nucleosides and trehalose in Corynebacterium glutamicum. The molecules of the invention can be used to modulate the production of fine chemicals in microorganisms such as C.glutamicum either directly (for example when modulation of the lysine biosynthesis protein has a direct effect on the lysine production or production efficiency of the organism) or indirectly, but results in an increase in the yield or production efficiency of the desired compound (for example when modulation of the nucleotide biosynthesis protein activity has an effect on the organic or fatty acid production of the bacterium, possibly due to growth improvement or increased supply of essential cofactors, energy compounds or precursor molecules). Various aspects of the invention are described in further detail below.

I. Fine chemicals

The term "fine chemicals" is well known in the art and includes molecules produced by organisms used in various industries, such as, but not limited to, the pharmaceutical, agricultural and cosmetic industries. Such compounds include organic acids such as tartaric, itaconic and diaminopimelic acids, proteinogenic and nonproteinogenic amino acids, purine and pyrimidine bases, nucleosides, and Nucleotides (such as described, for example, in Kuniaka, A. (1996) Nucleotides and related compounds, p.561-612, in Biotechnology vol.6, Rehm et al, eds. VCH: Weinheim and references contained therein), Lipids, saturated and unsaturated fatty acids (such as arachidonic acid), glycols (such as, for example, propane and butane diols), aromatic compounds (such as, for example, aromatic amines, vanillin and indigoids), Vitamins and cofactors (see Ullmann's Encyclopedia of Industrial chemistry, A27, "Vitamins", p.443-613 (VCH: Weinheimia and Chemicals, chemistry, Inc., and chemistry, Inc., luminescence, chemistry, P.1995, chemistry, and chemistry, and research, research, and the Society for Free radial Research-Asia, hold Sept.1-3, 1994 at Penang, Malaysia, AOCS Press, (1995)), enzyme, polyketide (ployketides) (Cane et al, (1998) Science 282: 63-68), and all of the methods described in Gutcho (1983) Chemicals by Fermentation, Noyes Data Corporation, ISBN: 0818805086 and references therein. The metabolism and the use of certain of these fine chemicals is described in further detail below.

A. Metabolism and use of amino acids

Amino acids comprise the basic building blocks of all proteins and are likewise necessary for the normal cellular biological function of all organisms. The term "amino acid" is well known in the art. There are 20 kinds of amino acids of protein origin, which are structural units of proteins, and are linked to each other by peptide bonds, whereas non-protein-origin amino acids (several hundred kinds are known) are not generally present in proteins (see Ulmann's Encyclopedia of Industrial Chemistry, vol. A2, p.57-97 VCH: Weinheim (1985)). Albeit with L-amino groupAcids are generally the only type found in naturally occurring proteins, but amino acids can be in either the D-or L-optical configuration. The biosynthetic or degradative pathways for each of the 20 proteinogenic amino acids are characterized individually in prokaryotic or eukaryotic cells (see, e.g., Stryer, L. biochemistry, 3)^rdedition, pages 578-590 (1988)). "essential" amino acids (histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan and valine) are so named because the complex biosynthesis of these amino acids is usually an essential nutrient condition, and they can be converted into the remaining 11 "nonessential" amino acids (alanine, arginine, asparagine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, proline, serine, tyrosine) by simple biosynthetic pathways. Although higher organisms do have the ability to synthesize some of these amino acids, essential amino acids must be supplemented from the diet for normal protein synthesis.

In addition to their function in protein synthesis, these amino acids are interesting chemical substances by themselves, and many of them have various applications in the food, feed, chemical, cosmetic, agricultural and pharmaceutical industries. Lysine is not only an important amino acid in nutrition for humans, but also for monogastric animals such as poultry and pigs. Glutamic acid is the most commonly used flavor additive (monosodium glutamate, MSG) and is widely used throughout the food industry as is aspartic acid, glycine, cysteine. Glycine, L-methionine and tryptophan are all used in the pharmaceutical industry. Glutamine, valine, leucine, isoleucine, histidine, arginine, proline, serine and alanine are all used in the pharmaceutical and cosmetic industries. Threonine, tryptophan and D/L-methionine are commonly used feed additives (Leuchtenberger, W. (1996) Amino aids-technical production and use, p.466-502 in Rehm et al. (eds.) biochemistry vol.6, chapter 14a, VCH: Weinheim). In addition, these amino acids are also useful as precursors for the synthesis of amino acids and protein synthesis, such as N-acetylcysteine, S-carboxymethyl-L-cysteine, (S) -5-hydroxytryptophan, and others as described in Ulmann' S Encyclopedia of Industrial Chemistry, vol. A2, p.57-97 VCH: the molecule described in Weinheim, 1985.

In organisms capable of producing natural amino acids, such as bacteria, the biosynthesis of these natural amino acids is well-understood (biosynthesis of bacterial amino acids and regulation thereof, see Umbarger, H.E. (1978) Ann. Rev. biochem.47: 533. sup. 606.) aspartate is synthesized by the reductive amination of α -ketoglutarate, the latter being an intermediate of the citric acid cycle, glutamine, proline and arginine all being produced sequentially from glutamate serine biosynthesis is a three-step process starting with 3-phosphoglycerate (an intermediate of glycolysis), after each step of oxidation, transamination and hydrolysis, ending with the amino acid cysteine and glycine being produced from serine, the former being produced by the condensation of homocysteine and serine, the latter being produced by the transfer of the β -carbon atom to tetrahydrofolate, the reaction being catalyzed by serine hydroxymethyltransferase phenylalanine and tyrosine, by 4-phosphoerythrose and phosphoenolpyruvate in a 9-step of glycolysis, the side chain β -carbon atom being synthesized by the biosynthetic pathway of phenylalanine and tyrosine, the final tyrosine, the serine biosynthesis being produced by the enzymatic conversion of the serine, threonine, the serine, threonine, the serine, the serine, the.

Amino acids beyond those required for cellular protein synthesis are not storable, but rather are degraded to provide intermediates for the cellular major metabolic pathway (for review see Stryer, L.B)iochemistry 3^rded.Ch.21 "Amino Acid Degradation and the Urea Cycle" p.495-516 (1988)). Although cells can convert excess amino acids into useful metabolic intermediates, the production of amino acids consumes a lot of energy, precursor molecules and enzymes required for synthesis. It is therefore not surprising that the regulation of amino acid biosynthesis by feedback inhibition, the presence of a particular amino acid, can slow down or completely stop its own production (for a review of the feedback mechanism of the amino acid biosynthesis pathway, see Stryer, L.biochemistry 3)^rdCh.24, "Biosynthesis of amino acids and Heme" p.575-600 (1988)). Thus, the yield of any particular amino acid is limited by the number of amino acids present in the cell.

B. Metabolism and use of vitamins, cofactors and trophic factors

Vitamins, cofactors and trophic factors comprise another group of molecules that, although other organisms, such as bacteria, can synthesize, higher animals lose their ability to synthesize them and can only ingest them. These molecules are either biologically active substances themselves, or precursors of biologically active substances, which may be electron carriers or intermediatesof various metabolic pathways. In addition to their nutritional value, these compounds are also of great industrial interest as pigments, antioxidants and catalysts or other processing aids. (for a review of the structure, activity and Industrial application of these compounds, see, for example, Ullmann's Encyclopedia of Industrial Chemistry, "Vitamins" vol. A27, p.443-613 VCH: Weinheim 1996.) "Vitamins" are well known in the art and include nutrients which are required for normal functioning of the organism but which cannot be synthesized by itself. Vitamins may include cofactors and trophic factor compounds. The term "cofactor" encompasses non-proteinaceous compounds required for normal enzymatic activity. These compounds may be inorganic or organic; the cofactor molecules of the present invention are preferably organic. The term "trophic factor" encompasses dietary supplements beneficial to plants and animals, particularly humans. Examples of such molecules are vitamins, antioxidants and certain lipids (e.g. polyunsaturated fatty acids).

The biosynthesis of these molecules in organisms, such as bacteria, capable of producing these molecules has been identified for the most part (Ullman' S Encyclopedia of Industrial Chemistry, "Vitamins" vol. A27, p.443-613, VCH: Weinheim, 1996; Michal, G. (1999) Biochemical Pathways: An Atlas of Biochemistry and Molecular biology. John Wiley&Sons; Ong, A.S., Niki, E.&Packer, L. (1995) "Nutrition, Lipids, Health, and Disease" Proceedings of the UNESCO/fermentation of Scientific and technical Association in Malaysis, and the radio for Free-Research, the biosynthesis of these molecules in bacteria, AOX, S: journal of Molecular biology, 1994, protein

Thiamine (vitamin B1) is produced from pyrimidines and thiazoles via chemical ligation riboflavin (vitamin B2) is synthesized from guanosine 5 ' -triphosphate and ribose 5 ' -phosphate riboflavin which in turn is used to synthesize Flavin Mononucleotide (FMN) and Flavin Adenine Dinucleotide (FAD), a group of compounds known as "vitamin B6" (e.g., pyridoxine, pyridoxamine, pyridoxal 5 ' -phosphate, and the commercial pyridoxal hydrochloride) are all derivatives of the common structural unit 5-hydroxy-6-methylpyridine.

Many of the corresponding proteins have also been found involved in the synthesis of the iron cluster (Fe-cluster) and are members of the nifS family of proteins lipoic acid, which is derived from octanoic acid, is used as a coenzyme in energy metabolism and can be part of the pyruvate dehydrogenase complex and α -ketoglutarate dehydrogenase complex folate, a group of folate derivatives, in turn derived from L-glutamic acid, p-aminobenzoic acid and 6-methylpterin.

Corrinoids (e.g. cobalamin, and in particular vitamin B12) and porphyrins are among the chemical species characterized by the tetrapyrrole ring system. The biosynthesis of vitamin B12 is so complex that its characteristics are not fully understood, but many of the enzymes and substrates involved are now known. Nicotinic acid (nicotinate) and nicotine are pyridine-based derivatives, also known as "nixin". Nisin is a precursor of the important coenzymes NAD (nicotinamide adenine dinucleotide) and NADP (nicotinamide adenine dinucleotide phosphate) and their reduced forms.

Although some of these compounds can also be produced in large-scale microbial cultures, such as riboflavin, vitamin B6, pantothenic acid and biotin, large-scale production of these compounds is also dependent to a large extent on non-cellular chemical systems. Vitamin B12 alone, due to the complexity of its synthesis, can only be produced by fermentation. In vitro methods require considerable material and time investment, often at great expense.

C. Metabolism and use of purines, pyrimidines, nucleosides and nucleotides

Purine and pyrimidine metabolic genes and their corresponding proteins are important targets for the treatment of neoplastic diseases and viral infections. The terms "purine" and "pyrimidine" encompass nitrogenous bases as constituents of nucleic acids, coenzymes and nucleotides. The term "nucleotide" encompasses the basic building blocks of a nucleic acid molecule consisting of a nitrogenous base, a pentose (for RNA, the pentose is ribose; for DNA, the pentose is deoxyribose), and phosphoric acid. The term "nucleoside" encompasses molecules that are precursors of nucleotides, but lack the phosphate moiety that nucleotides possess. By inhibiting the biosynthesis of these molecules, or the movement for the synthesis of nucleic acid molecules, it is possible to inhibit the synthesis of RNA and DNA; by inhibiting this activity by targeting tumor cells, the energy of tumor cell division and replication may be inhibited. In addition, some nucleotides are not used to form nucleic acids, but rather are used as energy stores (e.g., AMPs) or coenzymes (e.g., FAD and NAD).

Several publications describe the use of these chemicals as such medical indications by influencing the metabolism of purines and/or pyrimidines (e.g., Christopherson, R.I. and Lyons, S.D. (1990) "content inhibitors of de novo pyrimide and purine biosyntheses anaerobic therapeutic agents," Med.Res. reviews 10: 505) 548). Research involving purine and pyrimidine metabolic enzymes has focused on the development of new drugs that may be used, for example, as immunosuppressive or antiproliferative agents (Smith, J.L., (1995) "Enzyme in nucleic acids synthesis." curr. Opin. Structure. biol. 5: 752-. However, purine and pyrimidine bases, nucleosides and nucleotides also have additional effects: as intermediates in the biosynthesis of many fine chemicals (e.g.thiamine, S-adenosylmethionine, folic acid, or riboflavin), as carriers of cellular energy (e.g.ATP or GTP), and as chemicals per se, usually as flavor enhancers (e.g.IMP or GMP) or several medical applications (see, e.g.Kuninaka, A. (1996) Nucleotides and Related Compounds in Biotechnology vol.6, Rehm et al, eds. VCH: Weinheim, p.561-612). Also, enzymes involved in purine, pyrimidine, nucleoside or nucleotide metabolism are increasingly being developed as targets of action for crop protection chemicals, including fungicides, herbicides and insecticides.

The metabolism of these compounds in bacteria is characterised (comments, see, for example, Zalkin, H.and Dixon, J.E. (1992) "de novo pigment nucleic biosyntheses", in: Progress in nucleic acids Research and Molecular Biology, vol.42, Academic Press:, p.259-287; and Michal, G. (1999) "Nucleotides and Nucleotides", Chapter 8 in biochemical Pathway: An animal Atlas of Biochemistry and Molecular Biology, Wiley: New York). Purine metabolism has been the subject of intense research and is essential for normal cellular function. Impaired purine metabolism in higher animals can cause serious diseases such as gout. Purine nucleotides are synthesized from 5 '-phosphoribosyl, through a series of steps via the intermediate inosine 5' -phosphate (IMP), ultimately yielding guanine 5 '-monophosphate (GMP) and adenine 5' -monophosphate (AMP), from which the triphosphate forms used as nucleotides are formed. These compounds also serve as energy stores, the degradation of which provides energy for a variety of different biochemical processes in the cell. Pyrimidine biosynthesis is via the formation of uridine 5 '-phosphate (UMP) from ribose 5' -phosphate. UMP is subsequently converted to cytosine 5' -triphosphate (CTP). All of these deoxyforms of nucleotides are produced by a one-step reduction from the ribose diphosphate form of the nucleotide to the deoxyribose diphosphate form of the nucleotide. Upon phosphorylation, these molecules can participate in DNA synthesis.

D. Metabolism and use of trehalose

Trehalose comprises two glucosemolecules linked via α -1, is commonly used in the food industry as a sweetener, dried food or frozen food additive, and in beverages, and it is also used in the pharmaceutical, cosmetic and biotechnological industries (see, e.g., Nishimoto et al, (1998) U.S. patent No.5,759, 610; Singer, M.A. and Lindquist, S. (1998) Trends Biotech.16: 460. 467; Paiva, C.L.A. and Panel, A.D (1996) Biotech.Ann.Rev.2: 293. 314; Shiosaka, M. (1997) J.Japan 172: 97-102.) enzymes in many microorganisms can produce trehalose and release it naturally into the surrounding medium, from which it can be collected using methods well known in the art.

Elements and methods of the invention

The present invention is based, at least in part, on the discovery of novel molecules, referred to herein as MP nucleic acid and protein molecules, that function or function in one or more cellular metabolic pathways. In one embodiment, the MP molecule catalyzes an enzymatic reaction in one or more amino acid, vitamin, cofactor, trophic factor, nucleotide, nucleoside, or trehalose metabolic pathways. In a preferred embodiment, the activity of one or more MP molecules in the amino acid, vitamin, cofactor, trophic factor, nucleotide, nucleoside or trehalose metabolic pathway of Corynebacterium glutamicum of the present invention has an effect on the production of a desired fine chemical with this microorganism. In a particularly preferred embodiment, the activity of the MP molecules of the invention is modulated such that the efficiency or yield of the metabolic pathway in which the MP proteins of the invention are involved is modulated, which directly or indirectly affects the production and efficiency of production of one or more fine chemicals from C.glutamicum.

The term "MP protein" or "MP polypeptide" encompasses proteins that function in one or more amino acid, vitamin, cofactor, trophic factor, nucleotide, nucleoside, or trehalose metabolic pathways, such as catalyzing enzymatic reactions therein. Examples of MP proteins include those encoded by MP genes listed as odd-numbered in the sequence listing. The term "MP gene" or "MP nucleic acid sequence" encompasses a nucleic acid sequence encoding an MP protein, which comprises the coding region and the corresponding untranslated 5 'and 3' sequence regions. Examples of MP genes include those listed in Table 1. The terms "production" or "productivity" are well known in the art and encompass the concentration of a fermentation product (e.g., a desired fine chemical) at a given time and in a given fermentation volume (e.g., kilograms of product per liter per hour). The term "production efficiency" encompasses the time required to reach a particular production level (e.g.how long it takes for the cells to reach a particular fine chemical). The terms "yield", "product/carbon yield" are well known in the art and encompass the efficiency of the conversion of a carbon source into a product (e.g., a fine chemical). For example, it is often written as kilograms of product per kilogram of carbon source. By increasing the yield or production of a compound, the number of molecules recovered can be increased, or the number of molecules recovered that are useful for the compound in a given number of cultures in a given time can be increased. The term "biosynthesis" or "biosynthetic pathway" is well known in the art and encompasses the synthesis of compounds, particularly organic compounds, in a cell from intermediate compounds through a process that may be multistep and highly regulated. The term "degradation" or a "degradation pathway" is well known in the art and encompasses the breakdown of a compound, preferably an organic compound, into degradation products (generally, smaller or less complex molecules) in a cell via a process that can be multi-step and highly regulated. The term "metabolism" is well known in the art and encompasses all of the biochemical reactions that occur in an organism. Thus, the metabolism of a particular compound (e.g., the metabolism of an amino acid such as glycine) includes all biosynthetic, modification, and degradation pathways in a cell that are associated with the compound.

In another embodiment, the MP molecules of the invention are capable of modulating the production of a desired compound, such as a fine chemical, in a microorganism, such as Corynebacterium glutamicum. One or more amino acid, vitamin, cofactor, trophic factor, nucleotide, nucleoside, or trehalose biosynthetic or degradative enzyme of the invention can be manipulated using recombinant genetic techniques to modulate its activity. For example, the efficiency of a biosynthetic enzyme may be increased, or its allosteric control region disrupted to prevent feedback inhibition of compound production. Similarly, the degrading enzyme may be deleted or modified by substitution, deletion or addition such that its degrading activity towards the desired compound is reduced without affecting the viability of the cell. In each case, the overall yield or productivity of the desired fine chemical is increased.

Alterations of the protein and nucleotide molecules of the invention may also enhance the production of other fine chemicals than amino acids, vitamins, cofactors, trophic factors, nucleotides, nucleosides, or trehalose. The metabolism of any one compound is necessarily linked to other biosynthetic and degradation pathways within the cell, and the necessary cofactors, intermediates or substrates in one pathway may be supplied by or limited by other pathways of the same kind. Thus, by adjusting the activity of one or more proteins of the invention, the production or efficiency of the activity of another fine chemical biosynthetic or degradation pathway may be influenced. For example, amino acids may serve as building blocks for all proteins, but their presence in the cell at levels that may limit protein synthesis; thus, by increasing the efficiency or yield ofproduction of one or more amino acids within a cell, proteins such as biosynthetic or degradative proteins can be more easily synthesized. Likewise, where alterations in metabolic pathway enzymes make particular side reactions more favorable or unfavorable, they may result in over-production or under-production of one or more compounds that are useful as intermediates or substrates for the production of a desired fine chemical.

The isolated nucleic acid sequence of the present invention is contained in the genome of a strain of Corynebacterium glutamicum available from the American type culture Collection under accession number ATCC 13032. The isolated nucleic acid sequence of the MP DNA of Corynebacterium glutamicum, as well as the predicted amino acid sequence of the MP protein of Corynebacterium glutamicum, are listed as odd-numbered and even-numbered sequence numbers in the sequence listing, respectively. Computer analysis is performed and these nucleic acid sequences are classified and/or identified as sequences encoding metabolic pathway proteins.

The present invention also relates to a protein having an amino acid sequence having sufficient homology to the amino acid sequence of the present invention (for example, a sequence of an even-numbered sequence number in the sequence listing). As used herein, a protein having an amino acid sequence with sufficient homology to a selected amino acid sequence has at least about 50% homology to the selected amino acid sequence, e.g., the entire sequence of the selected amino acid. A protein having an amino acid sequence with substantial homology to the selected amino acid sequence may also have at least about 50-60%, preferably at least about 60%, more preferably at least about 70%, 80%, 90%, and most preferably at least about 95%, 96%, 97%, 98%, 99% or more homology to the selected amino acid sequence.

The MP protein of the invention, or a biologically active portion or fragment thereof, is capable of catalyzing an enzymatic reaction in one or more amino acid, vitamin, cofactor, trophic factor, nucleotide, nucleoside, or trehalose metabolic pathways, or has one or more activities listed in table 1.

The following sections describe various aspects of the invention in more detail:

A. isolated nucleic acid molecules

One aspect of the invention relates to isolated nucleic acid molecules encoding MP polypeptides or biologically active portions thereof, as well as nucleic acid molecule fragments sufficient for use as hybridization probes or primers for identifying or amplifying MP-encoding nucleic acids (e.g., MP DNA). As used herein, the term "nucleic acid molecule" is meant to encompass DNA molecules (e.g., cDNA or genomic DNA) and RNA molecules (e.g., mRNA), as well as analogs of DNA or RNA produced from nucleotide analogs. The term also includes untranslated sequences located at the 3 'and 5' ends of the coding region of a gene: at least 100 nucleotides of the sequence upstream of the 5 'end of the coding region and at least 20 nucleotides of the sequence downstream of the 3' end of the coding region of the gene. The nucleic acid molecule may be single-stranded or double-stranded, but is preferably double-stranded DNA. An "isolated" nucleic acid molecule refers to a nucleic acid molecule that is separated from other nucleic acid molecules that are present in the natural source of the nucleic acid. Preferably, an "isolated" nucleic acid does not contain sequences that naturally flank the nucleic acid in the genomic DNA of the organism from which the nucleic acid was obtained (e.g., sequences located at the 5 'and 3' ends of the nucleic acid). For example, in various embodiments, an isolated MP nucleic acid molecule can contain less than about 5kb, 4kb, 3kb, 2kb, 1kb, 0.5kb, or 0.1kb of nucleotide sequences that naturally flank the genomic DNAnucleic acid molecule of the cell from which the nucleic acid is obtained (e.g., a C.glutamicum cell). In addition, an "isolated" nucleic acid molecule, such as a DNA molecule, may be substantially free of other cellular material or culture medium when produced by recombinant techniques, and may be free of chemical precursors or other chemicals when chemically synthesized.

Nucleic acid molecules of the invention, such as the nucleotide sequences of odd-numbered SEQ ID NOs of the sequence Listing, or portions thereof, can be isolated by standard molecular biology techniques and the sequence information provided herein. For example, the Corynebacterium glutamicum MP DNA may be derived from Corynebacterium glutamicumIn the library, all or a portion of one of the odd-numbered sequence numbers in the sequence listing is used as a hybridization probe, as well as standard hybridization techniques (e.g., as described in Sambrook, J., Fritsh, E.F., and Maniatis, T.molecular Cloning: A Laboratory Manual.2)^nded.Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989). In addition, a nucleic acid molecule comprising all or a part of a nucleic acid sequence of the present invention (e.g., a nucleotide sequence having an odd-numbered sequence number in the sequence listing) can be isolated by polymerase chain reaction using an oligonucleotide primer designed based on the sequence (e.g., a nucleic acid molecule comprising all or a part of a nucleic acid sequence of the present invention (e.g., a nucleotide sequence having an odd-numbered sequence number in the sequence listing) can be isolated by polymerase chain reaction using an oligonucleotide primer designed based on the same sequence). For example, mRNA can be isolated from normal endothelial cells (e.g., using the guanidine thiocyanate extraction method of Chirgwin et al (1979) Biochemistry 18: 5294-. Oligonucleotide primers synthesized for polymerase chain reaction can be designed based on one of the nucleotide sequences listed in the sequence listing. The nucleic acids of the invention may be amplified using cDNA or alternatively genomic DNA as a template, with appropriate oligonucleotide primers, according to standard PCR amplification techniques. The nucleic acid thus amplified can be cloned into an appropriate vector and characterized by DNA sequence analysis. Alternatively, oligonucleotides corresponding to MP nucleotide sequences may be prepared using standard synthetic techniques, e.g., using an automated DNA synthesizer.

In a preferred embodiment, the isolated nucleic acid molecule of the invention comprises a nucleotide sequence as set forth in the sequence listing. The nucleic acid sequences of the invention, such as those listed in the sequence listing, are identical to the MP DNA of Corynebacterium glutamicum of the invention. These DNAs contain sequences encoding MP protein (i.e., "coding region", shown in the sequence of each odd-numbered sequence in the sequence Listing), as well as 5 'non-coding sequences and 3' non-coding sequences, also shown in the sequence of each odd-numbered sequence in the sequence Listing. Alternatively, the nucleic acid molecule may comprise only the coding region of the nucleic acid sequence in the sequence listing.

For purposes of this application, it is understood that each nucleic acid and amino acid sequence listed in the sequence listing has an RXA, RXN, RXS or RXC number for identification, "RXA", "RXN", "RXS", or "RXC" followed by 5 digits (i.e., RXA00007, RXN00023, RXS00116, or RXC 00128). Each nucleic acid sequence comprises at most three parts: 5' upstream region, coding region, downstream region. Each portion of the three areas is identified by the same RXA, RXN, RXS, or RXC designation to eliminate confusion. Thus, the recitation of "an odd numbered sequence in the sequence listing" refers to any nucleic acid sequence in the sequence listing, which may also be distinguished from each other by their different RXA, RXN, RXS, or RXC designations. The coding region of each such sequence is translated into the corresponding amino acid sequence, which is also listed in the sequence listing as an even-numbered sequence number immediately following the corresponding nucleic acid sequence. For example, the coding region of RXA02229 is set forth in SEQ ID NO: 1 and which encodes an amino acid sequence set forth in SEQ ID NO: 2. the nucleic acid molecule sequences of the present invention, and the amino acid molecules encoded thereby, are represented by the same names RXA, RXN, RXS, or RXC, so that they are easily related to each other. For example, the amino acid sequences designated RXA02229, RX00351, RXs02970, and RXC02390 are translations of the nucleotide sequences encoding the RXA02229, RX00351, RXs02970, and RXC02390 nucleic acid molecules, respectively. The correspondence between the nucleotide and amino acid sequences of the RXA, RXN, RXS and RXC of the present invention, as well as their assigned sequence numbers, are listed in table 1.

Several genes of the present invention are "F-designated genes". F-designated genes include those listed in Table 1 and preceded by the designation "F" for RXA, RXN, RXS, or RXC. For example, SEQ ID NO: 5, designated "F RXA 01009" as shown in Table 1, is an F-designated gene, as well as the amino acid sequence shown in SEQ ID NO: 73. 75 and 77 (designated "F RXA 00007", F RXA00364 "and" F RXA00367 ", respectively, in Table 1).

In one embodiment, the nucleic acid molecule of the invention does not comprise those of corynebacterium glutamicum which are compiled in table 2. For the dapD gene, the sequence of the gene is published in Wehrmann, a., et al (1998) j.bacteriol.180 (12): 3159-3165. However, the inventors of the present application have obtained much longer versions than published versions. The published version is said to use the wrong actual codons and thereforerepresents only a part of the true coding region.

In another preferred embodiment, the isolated nucleic acid molecules of the invention comprise those that are the complement of the nucleotide sequence of the invention (e.g., the sequence of an odd-numbered sequence in the sequence listing) or a portion thereof. A nucleic acid molecule that is complementary to a nucleotide sequence of the present invention means that the molecule is sufficiently complementary to a nucleotide sequence (e.g., an odd-numbered sequence number sequence) listed in the sequence listing so that it can hybridize to a nucleotide sequence of the present invention to form a stable duplex.

Also in another preferred embodiment, an isolated nucleic acid molecule of the invention comprises a nucleotide sequence that is at least about 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, or 60% homologous to a nucleotide sequence of the invention (e.g., an odd-numbered sequence number sequence in the sequence listing) or a portion thereof, preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70% homologous, more preferably at least about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 88%, 89%, or 90%, or 91%, 92%, 93%, 94%, and even more preferably at least about 95%, 96%, 97%, 98%, 99% or more homology. Ranges and consistency values intermediate to the above-recited ranges (e.g., 70-90% consistency or 80-95% consistency) are also encompassed within the invention. For example, ranges of consistency values are included that are combinations of the upper and/or lower limits recited above. In another preferred embodiment, an isolated nucleic acid molecule of the invention comprises a nucleotide sequence that hybridizes, e.g., under stringent conditions, to a nucleotide sequence of the invention or a portion thereof.

In addition, the nucleic acid molecule of the presentinvention may comprise only a portion of the coding region of the sequence having odd-numbered sequence numbers in the sequence listing, for example, a fragment that can be used as a probe or primer, or a fragment that encodes a biologically active portion of an MP protein. The nucleotide sequence cloned from the MP gene from C.glutamicum allows the production of probes and primers designed to identify and/or clone MP homologs in other cell types or other organisms, as well as MP homologs in other coryneform bacteria or related species. Probes/primers typically comprise fairly purified oligonucleotides. Oligonucleotides typically comprise a region of nucleotide sequence that hybridizes under stringent hybridization conditions to at least about 12, preferably about 25, more preferably about 40, 50, or 75 consecutive nucleotides of the sense strand of a nucleotide sequence of the invention (e.g., an odd-numbered sequence of the sequence listing), the antisense sequence of such sequences, or a naturally occurring mutant thereof. The primers based on the nucleotide sequences of the present invention can be used in PCR reactions for cloning MP homologs. Probes based on MP nucleotide sequences can be used to detect the transcriptional or genomic sequences of the same or homologous proteins. In a preferred embodiment, the probe further comprises an additional attached labeling group, for example, the labeling group may be a radioisotope, a fluorescent compound, an enzyme, or a cofactor for an enzyme. Such probes can be used as part of a diagnostic test kit for identifying cells that misexpress MP protein, such as by measuring the level of MP-encoding nucleic acid in sample cells, e.g., detecting the level of MP mRNA, or determining whether the genomic MP gene has been mutated or deleted.

In one embodiment, the nucleic acid molecule of the invention encodes a protein or a portion thereof having an amino acid sequence that is sufficiently homologous to an amino acidsequence of the invention (e.g., the even numbered sequence numbers in the sequence listing) such that the protein or portion thereof can catalyze an enzymatic reaction in an amino acid, vitamin, cofactor, trophic factor, nucleotide, nucleoside, or trehalose metabolic pathway. As used herein, the term "substantial homology" refers to an amino acid sequence of a protein, or portion thereof, that contains a minimum number of amino acid residues that are identical or equivalent to an amino acid sequence of the present invention (e.g., amino acid residues having similar side chains as the amino acid residues in the sequence numbered even in the sequence listing), such that the protein, or portion thereof, is capable of catalyzing an enzymatic reaction in an amino acid, vitamin, cofactor, trophic factor, nucleotide, nucleoside, or trehalose metabolic pathway in Corynebacterium glutamicum. Such a member of a metabolic pathway protein, as described herein, functions to catalyze the biosynthesis or degradation of one or more amino acids, vitamins, cofactors, trophic factors, nucleotides, nucleosides, or trehalose. Examples of such activities are also described herein. Thus, the "function of an MP protein" has an effect on one or more of these metabolic pathways and/or directly or indirectly affects the yield, production and/or efficiency of production of one or more fine chemicals. Examples of MP protein activities are listed in Table 1.

In another embodiment, the protein is at least about 50-60% homologous, preferably at least about 60-70% homologous, more preferably at least about 70-80%, 80-90%, 90-95% homologous, and most preferably at least about 96%, 97%, 98%, 99% or more homologous to all amino acid sequences of the invention (e.g., even numbered sequence numbers in the sequence listing).

The MP nucleic acid molecules of the invention encode a portion of a protein, preferably a biologically active portion of an MP protein. As used herein, the term "biologically active portion of an MP protein" is meant to encompass a portion, e.g., a domain/motif, of an MP protein that is capable of catalyzing an enzymatic reaction in one or more amino acid, vitamin, cofactor, trophic factor, nucleotide, nucleoside, or trehalose metabolic pathways in c. An enzyme activity assay can be performed to determine whether an MP protein, or biologically active portion thereof, can catalyze an enzymatic reaction in an amino acid, vitamin, cofactor, trophic factor, nucleotide, nucleoside, or trehalose metabolic pathway. Such analysis methods are well known to those skilled in the art and are described in detail in exemplary example 8.

Additional nucleic acid fragments encoding biologically active portions of an MP protein may be prepared by isolating a portion of an amino acid sequence of the invention (e.g., the even-numbered sequence number sequence in the sequence listing), expressing the encoded portion of an MP protein or polypeptide (e.g., by in vitro recombinant expression), and estimating the activity of the encoded portion of an MP protein or polypeptide.

Because of the degeneracy of the genetic code, and the resulting MP protein that is identical to the protein encoded by the nucleotide sequence of the present invention, the present invention further encompasses nucleic acid molecules that differ from the nucleotide sequence of the present invention (e.g., the sequence of odd-numbered SEQ ID NO: s of the sequence Listing) (and portions thereof). In another embodiment, an isolated nucleic acid molecule of the invention has a nucleotide sequence that encodes a protein having an amino acid sequence listed in the sequence listing (e.g., an even-numbered sequence number). In yet another embodiment, the nucleic acid molecule of the invention encodes a full-length C.glutamicum protein which has substantial homology to the amino acid sequence of the invention (encoded by the open reading frame of the sequence listing having odd-numbered sequence numbers).

In one embodiment, the sequences of the present invention are not meant to include sequences known in the prior art, such as those listed in Table 2 or Table 4, Genbank sequences that were previously effective in the present invention, as would be understood by one of skill in the art. In one embodiment, the invention encompasses nucleotide and amino acid sequences that have a percentage identity to the nucleotide and amino acid sequences of the invention that is greater than the percentage identity of sequences known in the art (e.g., the Genbank sequences (or the proteins encoded by the sequences) listed in table 2 or table 4) to the nucleotide and amino acid sequences of the invention. For example, the invention encompasses nucleotide sequences having greater than and/or at least 40% identity to the nucleotide sequence designated RXA00115(SEQ ID NO: 185), nucleotide sequences having greater than and/or at least% identity to the nucleotide sequence designated RXA00131(SEQ ID NO: 991), and nucleotide sequences having greater than and/or at least 39% identity to the nucleotide sequence designated RXA00219(SEQ ID NO: 345). One skilled in the art can calculate the low threshold value for percent identity for any particular sequence of the present invention by examining the 3 highest-met GPA-calculated percent identities given for each particular sequence listed in table 4, and by subtracting the highest GPA-calculated percent identity from one hundred percent. Those skilled in the art will also recognize nucleic acid and amino acid sequences having a percent identity greater than the low end threshold value thus calculated (e.g., at least 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, or 60%, preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70%, more preferably at least about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, or 90%, or 91%, 92%, 93%, 94%, and even more preferably at least about 95%, 96%, 97%, 98%, 99% or more identity) are also encompassed by the present invention.

One skilled in the art will appreciate that DNA polymorphisms that result in alterations in the amino acid sequence of an MP protein can exist in a population (e.g., a population of C.glutamicum) other than the C.glutamicum MP nucleotide sequence listed as an odd-numbered sequence number in the sequence listing. Genetic polymorphisms of this MP gene can exist in different individuals of a population due to variations in natural conditions. As used herein, the terms "gene" and "recombinant gene" refer to a nucleic acid molecule comprising an open reading frame encoding an MP protein, preferably an MP protein from Corynebacterium glutamicum. Such variations in natural conditions typically result in 1-5% changes in the nucleotide sequence of the MP gene. Any and all variations in natural conditions that do not alter the functional activity of the MP protein, such nucleotide changes, and resulting MP amino acid polymorphisms, are within the scope of the invention.

Nucleic acid molecules of the corresponding natural variants, and non-Corynebacterium glutamicum homologues of the MP DNA of Corynebacterium glutamicum of the present invention, may be isolated based on their homology to the MP nucleic acid molecules of Corynebacterium glutamicum using Corynebacterium glutamicum DNA or parts thereof as hybridization probe under stringent hybridization conditions according to standard hybridization techniques. Thus, in another embodiment, an isolated nucleic acid molecule of the invention is at least 15 nucleotides in length and hybridizes under stringent conditions to a nucleic acid molecule comprising a nucleotide sequence set forth as an odd-numbered nucleotide sequence in the sequence listing. In other embodiments, the nucleic acid molecule is at least 30, 50, 100, 250 or more nucleotides in length. As used herein, the term "hybridizes under stringent conditions" is meant to describe hybridization and washing conditions under which nucleotide sequences at least 60% homologous to each other typically hybridize to each other. Preferably, such conditions are that there is at least about 65%, more preferably at least about 70%, and even more preferably at least about 75 or more homology between the sequences, which maintain a typical hybridization with each other. Such stringent conditions are known to those skilled in the art and can be found in Ausubel et al, Current Protocols in molecular Biology, John Wiley&Sons, N.Y. (1989), 6.3.1-6.3.6. A preferred but not limiting stringent hybridization condition is to hybridize in6 XSSC at about 45 ℃ followed by one or more washes in 0.2 XSSC, 0.1% SDS at 50-65 ℃. Preferably, an isolated nucleic acid molecule of the invention hybridizes to a nucleotide sequence of the invention under stringent hybridization conditions, corresponding to the production of a naturally occurring nucleic acid molecule. As used herein, a "naturally-occurring" nucleic acid molecule refers to an RNA or DNA molecule having a nucleotide sequence that occurs in nature (e.g., encodes a native protein). In one embodiment, the nucleic acid encodes a native Corynebacterium glutamicum MP protein.

One skilled in the art will further appreciate that, in addition to naturally occurring variants of MP sequences present in a population, alterations may be introduced into the nucleotide sequences of the invention by mutation, resulting in alteration of the amino acid sequence of the encoded MP protein, without altering the function of the MP protein. For example, nucleotide substitutions may be made in the nucleotide sequences of the present invention which may result in amino acid substitutions of "non-essential" amino acid residues. "non-essential" amino acid residues refer to residues that can be altered in the wild-type sequence of an MP protein (e.g., the even-numbered sequence number sequence in the sequence listing) without altering the activity of the MP protein, while "essential" amino acid residues are required for MP protein activity. However, other amino acid residues (e.g., those that are not conserved or are only semi-conserved in the MP active domain) may not be necessary for activity and thus may also be altered without altering MP activity.

Thus, another aspect of the invention relates to nucleic acid molecules encoding MP proteins containing changes in amino acid residues that are not essential for MP activity. The amino acid sequences of these proteins differ from the even-numbered SEQ ID NO. sequences of the sequence Listing, yet retain at least one MP activity as described herein. In one embodiment, an isolated nucleic acid molecule comprises a nucleotide sequence encoding a protein, wherein the amino acid sequence of the protein has at least about 50% homology to the amino acid sequence of the present invention and is capable of catalyzing an enzymatic reaction in an amino acid, vitamin, cofactor, trophic factor, nucleotide, nucleoside, or trehalose metabolic pathway, or has one or more activities listed in Table 1. Preferably, the nucleic acid molecule encodes a protein that is at least about 50-60% homologous to an amino acid sequence having an odd-numbered sequence number from the sequence listing, more preferably at least about 60-70% homologous to such a sequence, even more preferably at least about 70-80%, 80-90%, 90-95% homologous to such a sequence, and most preferably at least about 96%, 97%, 98%, or 99% homologous to an amino acid sequence of the present invention.

To determine the percent homology of two amino acid sequences (e.g., one amino acid sequence of the invention with a mutant form thereof) or two nucleic acid sequences, the sequences are aligned for optimal comparison purposes (e.g., gaps can be introduced in the sequence of one protein or nucleicacid for optimal alignment with other proteins or nucleic acids). The amino acid residues at the corresponding amino acid positions or the nucleotides at the nucleic acid positions are then compared. When a position in a sequence (e.g., an amino acid sequence of the invention) is occupied by the same amino acid residue or nucleotide as the corresponding position in another sequence (e.g., a mutant form of the amino acid sequence), the molecule is homologous at that position (i.e., amino acid or nucleic acid "homology" as used herein is identical to amino acid or nucleic acid "identity"). The percent homology between two sequences is a function of the number of identical positions averaged over the sequence (i.e.,% identity [ # of identical positions/# x100 of all positions).

An isolated nucleic acid molecule encoding an MP protein homologous to a protein sequence of the invention (e.g., the sequence of even-numbered seq id No. s in the sequence listing) can be generated by introducing one or more nucleotide substitutions, insertions, deletions into the nucleotide sequence of the invention, thereby introducing one or more amino acid substitutions, insertions, deletions into the encoded protein, mutations can be introduced into the nucleotide sequence of the invention using standard techniques, such as site-directed mutagenesis and PCR-mediated mutagenesis, preferably conservative amino acid substitutions are made at one or more desired nonessential amino acid residues.

In addition to the nucleic acid molecules encoding MP proteins described above, another aspect of the invention pertains to isolated antisense nucleic acid molecules. "antisense" nucleic acids include nucleotide sequences that are complementary to "sense" nucleic acids that encode proteins, e.g., complementary to the coding strand of a double-stranded DNA molecule, or complementary to an mRNA sequence. Thus, the antisense nucleic acid can be linked to the sensenucleic acid by hydrogen bonding. The antisense nucleic acid may be complementary to the entire MP coding strand or may be complementary to only a portion thereof. In one embodiment, the antisense nucleic acid molecule is antisense to the "coding region" of the coding strand of the nucleotide sequence encoding the MP protein. The term "coding region" refers to a region of a nucleotide sequence that includes codons translated into amino acid residues (e.g., the entire coding region of SEQ ID No.1(RAX 02229) includes 1 to 825 nucleotides). In another embodiment, the antisense nucleic acid molecule is antisense to the coding strand of a nucleotide sequence encoding MP. The term "non-coding region" refers to 5 'and 3' sequences flanking the coding region that are not translated into amino acids (i.e., 5 'and 3' untranslated regions).

In view of the MP-encoding coding strand sequences disclosed herein (e.g., the odd-numbered sequence numbers listed in the sequence listing), the antisense nucleic acids of the invention can be designed according to Watson and Crick base-pairing rules. The antisense nucleic acid molecule can be complementary to the entire coding region of the MP mRNA, but more preferably is an oligonucleotide that is antisense to only a portion of the coding region or non-coding region of the MP mRNA. For example, the antisense oligonucleotide may be complementary to a region near the translation start position of MP mRNA. For example, the antisense oligonucleotide may be 5, 10, 15, 20, 25, 30, 35, 40, 45, or 50 nucleotides in length. The antisense nucleic acid molecules of the present invention can be constructed by chemical synthesis or enzymatic ligation using procedures known in the art. Antisense nucleic acids (e.g., antisense oligonucleotides) can be chemically synthesized using naturally occurring nucleotides or various modified nucleotides designed to increase the biological stability of the molecule or to increase the physical stability ofthe duplex formed between the antisense and sense nucleic acids, e.g., phosphorothioate derivatives and acridine substituted nucleotides can be used. Examples of modified nucleotides that can be used to generate antisense nucleic acids include 5-fluorouracil, 5-bromouracil, 5-chlorouracil, 5-iodouracil, hypoxanthine, xanthine, 4-acetylcytosine, 5- (carboxyhydroxymethyl) uracil, 5-carboxymethylaminomethyl-2-thiouracil, 5-carboxymethylaminomethyluracil, dihydrouracil, beta-D-galactosylinosine, N6-isopentyladenine, 1-methylguanine, 1-methylinosine, 2, 2-dimethylguanine, 2-methyladenine, 2-methylguanine, 3-methylcytosine, 5-methylcytosine, N6-adenine, 7-methylguanine, 5-methylaminomethyluracil, 5-methoxyaminomethyl uracil-2-thiouracil, beta-D-mannosyl queosine, 5' -methoxycarboxymethyl uracil, 5-methoxyuracil, 2-methylthio-N6-isopentyladenine, uracil-5-oxyacetic acid (v), wybutoxosine, pseudouracil, queosine, 2-thiocytosine, 5-methyl-2-thiouracil, 4-thiouracil, 5-methyluracil, uracil-5-oxyacetic acid methyl ester, uracil-5-oxyacetic acid (v), 5-methyl-2-thiouracil, 3- (3-amino-3-N-2-carboxypropyl) uracil, (acp3) w, and 2, 6-diaminopurine. Alternatively, the antisense nucleic acid can be biosynthesized using an expression vector in which the nucleic acid is subcloned into the expression vector in the antisense orientation (i.e., the RNA transcribed from the inserted nucleic acid is in the antisense orientation relative to the target nucleic acid inserted, as further described below).

The antisense nucleic acid molecules of the invention are typically administered to a cell or generated in situ such that they can hybridize to or bind to cellular mRNA and/or genomic DNA encoding an MP protein, thereby inhibiting the expression of the protein, e.g., inhibiting transcription and/or translation. Hybridization can be by conventional nucleotide complementarity to form a stable duplex, or, for example, when an antisense nucleic acid molecule binds to a DNA duplex, it interacts specifically withthe major groove of the duplex. Antisense molecules can be modified so that the molecule can specifically bind to a receptor or to a specific cell surface expressed antigen, e.g., binding of an antisense nucleic acid molecule to a polypeptide or antibody that binds to a cell surface receptor or antigen. Antisense nucleic acid molecules can also be delivered to cells using the vectors described herein. In order to obtain sufficient intracellular concentrations of antisense molecules, vectors in which the antisense nucleic acid molecule is placed under the control of a prokaryotic, viral or eukaryotic promoter are preferred.

In yet another embodiment, the antisense Nucleic acid molecule of the invention is an α -anomer Nucleic acid molecule α -anomer Nucleic acid molecule forms a specific double-stranded hybrid with complementary RNA in which the two strands run parallel to each other, as opposed to the usual β -unit (Gaultier et al (1987) Nucleic acids. Res.15: 6625-6641) the antisense Nucleic acid molecule may also comprise 2' -o-methylribonucleotides (Inoue et al (1987) Nucleic acids. Res.15: 6131-3148) or chemical RNA-DNA analogs (Inoue et al (1987) FEBS Lett.215: 327-330).

In yet another embodiment, the antisense nucleic acid molecule of the invention is a ribozyme. Ribozymes are catalytic RNA molecules that have ribonuclease activity and are capable of cleaving a single-stranded nucleic acid, such as mRNA, which has a region complementary to the single-stranded nucleic acid. Thus, ribozymes (e.g., hammerhead ribozymes (described in Haselhoff and Gerlach (1988) Nature 334: 585-. Ribozymes specific for MP-encoding nucleic acid molecules can be designed based on the MP DNA nucleotide sequence disclosed herein (i.e., SEQ ID NO: 1(RAX 02229)). For example, derivatives of Tetrahymena L-19 IVS RNA can be constructed whose active site nucleotide sequence is complementary to the nucleotide sequence of the cleaved MP-encoding mRNA. See, for example, Cech et al U.S. patent No.4,987,071 and Cech et al U.S. patent No.5, 116, 742. In addition, MP mRNA can be used in RNA molecule libraries for screening catalytic RNAs with specific ribozyme activity. See, e.g., Bartel, d.and Szostak, J.W (1993) Science 261: 1411-1418.

In addition, by targeting a nucleotide sequence complementary to the regulatory region of the MP nucleotide sequence (e.g., MP promoter and/or enhancer), a triple helix structure can be formed, which can prevent transcription of the MP gene in the target cell, and can inhibit the expression of the MP gene. See generally, Helene, c. (1991) Anticancer Drug des.6 (6): 569-84; helene, c.et al (1992) ann.n.y.acad.sci.660: 27-36; and Maher, L.J, (1992) Bioassays 14 (12): 807-15.

B. Recombinant expression vectors and host cells

Another aspect of the invention relates to a vector, preferably an expression vector, comprising a nucleic acid encoding an MP protein (or portion thereof). As used herein, the term "vector" refers to a nucleic acid molecule capable of being ligated to and transporting other nucleic acids. One type of vector is a "plasmid," which refers to a circular double-stranded DNA loop into which additional DNA segments are ligated. Another type of vector is a viral vector, wherein additional DNA segments can be ligated into the viral genome. Certain vectors are capable of autonomous replication in a host cell into which they are introduced (e.g., bacterial vectors having a bacterial origin of replication, and episomal mammalian vectors). Other vectors (e.g., non-episomal mammalian vectors) are integrated into the genome of a host cell upon introduction into the host cell, and thereby are replicated along with the host genome. In addition, certain vectors are capable of directing the expression of genes to which they are ligated. These vectors are referred to herein as "expression vectors". In general, recombinant DNA techniques use expression vectors, often in the form of plasmids. In the present specification, "plasmid" and "vector" may be used interchangeably, as the plasmid is the most commonly used form of vector. However, the present invention is intended to include such other forms of expression vectors, such as viral vectors (e.g., replication defective retroviruses, adenoviruses and adeno-associated viruses), which serve the same function.

The term "operably linked" in a recombinant expression vector means that the nucleotide sequence of interest is linked to the regulatory sequence in a manner that allows for expression of the nucleotide sequence (e.g., in an in vitro transcription/translation system, or in a host cell into which the vector is introduced), "operably linked" means that the promoter, enhancer, and other expression control elements (e.g., polyadenylation signals) are included in the recombinant expression vector, which regulatory sequence is described in, for example, Goeddel;. Gene expression Technology: Methods in Enzymology185, Academic Press, Sanego, CA (CA) including those sequences that direct constitutive expression of the nucleotide sequence in many types of host cells, and those sequences that direct expression of the protein in host cells, such as promoter, etc., antisense, etc., see 12, etc., for example, etc., can be used in the expression 5-11-5-or other expression vectors, etc., as disclosed in the like, so that are described in the invention, so that is used in the invention, so that is described in many types of the invention, such as in host cells, etc., in the invention, so that the invention, can be used in host cells, the invention, is used in which directs constitutive expression vector, the.

The recombinant expression vectors of the invention can be designed for expressing MP proteins in prokaryotic or eukaryotic cells. For example, MP genes can be expressed in bacterial cells such as C.glutamicum, insect cells (using baculovirus expression vectors), Yeast and other fungal cells (see Romanos, M.A.et. al. (1992) "expression in year" Yeast 8: 423. 488; van den Hondel, C.A.M.J.et. et. al. (1991) "expression in genome expression" in More than one species of Molecular genes in Fungi, J.W.Bennet. L.Laure, eds., p.396-428: expression in Sandyo; and van den Hondel, C.A.M.J.P.J.P.J.P.J.P.J.P. P.J. expression of Molecular genes, 1998. expression of strain in algae, strain of strain, strain of Bacillus strain, strain of strain, alga "expression of strain" strain of Bacillus ", see expression of strain J.P.M.M.P.M.M.M.M.J.P.M.M.M.P.M.M.P.S. 1. expression of strain, strain of strain, alga" expression of strain, strain of strain, strain of strain, strain of strain, strain of strain, see expression of strain, strain of strain, see, Plant, or a mammalian cell. Suitable host cells are described in Goeddel, Gene expression technology; methods in Enzymology185, Academic Press, San Diego, Calif. (1990) are discussed further. In addition, the recombinant expression vector can be transcribed and translated in vitro, for example, using T7 promoter regulatory sequences and T7 polymerase.

Protein expression in prokaryotic cells is often carried out by vectors containing constitutive or inducible promoters which direct the expression of fusion or non-fusion proteins. Fusion vectors add a certain number of amino acids to the encoded protein, usually at the amino terminus of the recombinant protein, but also at the C-terminus, or fused to an appropriate region in the protein. This fusion vector has 3 typical uses: 1) increasing expression of the recombinant protein; 2) increasing the solubility of the recombinant protein; and 3) ligands used as affinity purification to aid in the purification of the fusion protein. In fusion expression vectors, a protein cleavage site is often introduced at the junction of the fusion moiety and the recombinant protein, so that the recombinant proteincan be separated from the fusion moiety after purification of the fusion protein. Such enzymes, and their cognate recognition sequences, include factor Xa, thrombin and enterokinase.

Exemplary fusion expression vectors include pGEX (Pharmacia Biotech Inc; Smith, D.B.and Johnson, K.S (1988) Gene 67: 31-40), pMAL (New England Biolabs, Beverly, MA) and pRIT5(Pharmacia, Piscataway, N.J.), each fused to a recombinant protein of interest with glutathione S-transferase (GST), maltose E binding protein, or protein A. In one embodiment, the MP protein coding sequence is cloned into a pGEX expression vector, resulting in a vector encoding a fusion protein, which includes, from N-terminus to C-terminus, GST-thrombin cleavage site-X protein. The fusion protein can be purified by affinity chromatography using glutathione-agarose resin. The recombinant MP protein, which is separated from GST, can be obtained by cleaving the fusion protein with thrombin.

Examples of suitable E.coli inducible non-fusion expression vectors include pTrc (Amannet al., (1988) Gene 69: 301-315), pLG338, pACYC184, pBR322, pUC18, pUC19, pKC30, pRep4, pSH1, pSH2, pPLc236, pMBL24, pLG200, pUR290, pIN-III 113-B1, lambda gt11, pBdC1, and pET11d (Studier et al., expression Technology: Methods in Enzymology185, Academic Press, SanDiego, California (1990) 60-89; and Pouwelsin et al., eds. (1985) cloning SN. vector SN. Y., Neysek. 0444904018). Expression of the target gene from the pTrc vector is dependent on transcription by host RNA polymerase hybridizing to the trp-lac fusion promoter. Target gene expression from the pET11d vector was dependent on transcription from the T7 gn10-lac fusion promoter mediated by co-expressed viral RNA polymerase (T7 gn 1). The viral polymerase is provided by a lambda phage harboring the T7 gn1 gene under the transcriptional control of the lacUV 5 promoter residing in host strain BL21(DE3) or HMS174(DE 3). For transformation of other species of bacteria, a suitablevector may be selected. For example, plasmids pIJ101, pIJ364, pIJ702 and pIJ361 are known to be efficient for transformation of Streptomyces, while plasmids pUB110, pC194, or pBD214 are suitable for transformation of Bacillus species. Several plasmids which help to transfer genetic information into Corynebacterium include pHM1519, pBL1, pSA77 or pAJ667(Pouwels et al, eds. (1985) cloning vectors, Elsevier: New York IBSN 0444904018).

One approach to maximize recombinant protein Expression is to express in a host cell a protein that has a non-diminished ability to proteolytically cleave the recombinant protein (Gottesman, S., Gene Expression Technology: Methods in Enzymology185, Academic Press, San Diego, Calif. (1990) 119-128). Another alternative is to alter the Nucleic acid sequence of the Nucleic acid inserted into the expression vector so that the codons for each amino acid are preferentially used by the bacterium chosen for expression, for example Corynebacterium glutamicum (Wada et al (1992) Nucleic Acids Res.20: 2111-2118). Such alteration of the nucleic acid sequence of the invention may be carried out by standard DNA synthesis techniques.

In another embodiment, the MP protein expression vector is a yeast expression vector. Examples of vectors for expression by yeast S.cerivisae include pYepsec1(Baldari, et al., (1987) Embo J.6: 229. quadrature. 234), 2. mu.pAG-1, Yep6, Yep13, pEMBK Ye23, pMFa (Kurian and Herskowitz, (1982) Cell 30: 933. quadrature. 943), pJRY88(Schultz et al., (1987) Gene 54: 113. quadrature. 123), and pYES2(Invitrogen Corporation, San Diego, CA). Vectors and methods for constructing vectors suitable for use in other fungi, such as filamentous fungi, include those described in detail in: van den Hondel, c.a.m.j.j.&Punt, P.J. (1991) "Gene transfer systems and vector definition for filterous fungi, in: applied Molecular Genetics of Fungi, J.F.Peberdy, et al., eds., p.1-28, Cambridge University Press: cambridge, and Pouwelset et al, eds. (1985) Cloning Vectors, Elsevier: new York IBSN 0444904018).

In addition, the MP protein of the present invention can be expressed in insect cells using baculovirus expression vectors. Baculovirus vectors for expression of proteins in cultured insect cells (e.g., Sf9 cells) include the pAC series (Smith et al (1983) mol. cell biol. 3: 2156-2165) and the pVL series (Lucklow and Summer (1989) Virology 170: 31-39).

In another embodiment, the MP protein of the invention may be expressed in unicellular plant cells (e.g. algae) or in plant cells of higher plants (e.g. seed plants, such as crop plants). Examples of plant expression vectors include those detailed in the following documents: becker, d., Kemper, e., Schell, j.and Masterson, R. (1992) "New Plant combinatorial vectors with a selectable marker located proximal to the left border", Plant mol.biol.20: 1195-1197; and Bevan, M.W, (1984) "Binary Agrobacterium vectors for transformation", nuclear. 8711-8721, including pLGV23, pGHlac +, pBIN19, pAK2004 and pDH51(Pouwels et al, eds. (1985) Cloning vectors, Elsevier: New York IBSN 0444904018).

In yet another embodiment, the nucleic acids of the invention are expressed in mammalian cells using a mammalian expression vector. Examples of mammalian expression vectors include pCDM8(Seed, B. (1987) Nature 329: 840) and pMT2PC (Kaufman et al (1987) EMBO J.6: 187-195). The control functions of expression vectors, when used in mammals, are often provided by viral regulatory elements. For example, commonly used promoters are from polyoma, adenovirus 2, cytomegalovirus and simian virus 40. Other suitable expression systems for both prokaryotic and eukaryotic cells are described in Sambrook, j., Fritsh, e.f., and manitis, t.molecular cloning: chapter 16 and 17 of A Laboratory Manual.2nd, ed.Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989.

In another embodiment, recombinant mammalian expression vectors capable of directing expression of preferred nucleic acids in specific Cell types (e.g., tissue-specific regulatory elements are used to express the nucleic acids.) examples of suitable tissue-specific promoters include, but are not limited to, the albumin promoter (liver-specific; Pinkert et al (1987) Gene Dev.1: 268-277), the lymph-specific promoter (Calame and Eaton (1988) adv.Immunol.43: 235-275), the specific promoter of the T-Cell receptor (Winto and Baltimore (1989) EMBO J.8: 729-933) and the specific promoter of immunoglobulin (Banerji et al (1983) 33: 729-740; Queen and Baltimore (1983) 33: 729-741), the promoter of neurons (e.g., neurofilament promoter; devine and Bddy. 264) 33: 1989-1990) and the specific promoter of mammary gland proteins (1989) 120: 166-12), the milk 748 and milk promoter (1983) 33: 75: 741-166), the specific promoter of mammary gland proteins (e.g.g., mouse proteins), including the mouse proteins, mouse.

The invention furthermore provides recombinant expression vectors which contain the DNA molecules according to the invention, which are cloned in the expression vector in antisense orientation. That is, the DNA molecule may be operably linked to the regulatory sequence in a manner that allows for expression (by transcription of the DNA molecule) of an RNA molecule that is antisense to the MP mRNA. Regulatory sequences may be selected which direct the continuous expression of antisense RNA molecules in various cell types, for example viral promoters and/or enhancers, or regulatory sequences may be selected which direct the expression of continuous, tissue-specific or cell-type specific antisense RNA molecules. Antisense expression vectors can be in the form of recombinant plasmids, phagemids or attenuated viruses in which antisense nucleic acids are produced under the control of highly effective regulatory regions, the activity of which can be determined by the cell type into which the vector is introduced. For the use of Antisense genes to regulate gene expression, see Weintraub, H.et al, Antisense RNA as a molecular tool for Genetics analysis, Review-trends in Genetics, Vol.1(1) 1986.

In another aspect, the invention relates to a host cell into which a recombinant expression vector of the invention has been introduced. The terms "host cell" and "recombinant host cell" are used interchangeably herein. The term should be understood to refer not only to the particular cell selected, but also to the progeny or potential progeny of such a cell. Because mutations or environmental influences may cause certain modifications to occur during successful passages, these progeny cells may not, in fact, be identical to the parent cell, but are included within the scope of the term as used herein.

The host cell may be any prokaryotic or eukaryotic cell. For example, the MP protein may be expressed in bacterial cells such as C.glutamicum, insect cells, yeast cells, or mammalian cells (e.g., Chinese rat ovarian Cells (CHO) or COS cells). Other suitable host cells are well known to those skilled in the art. Corynebacterium glutamicum related microorganisms which can be used as host cells for the nucleic acid and protein molecules of the invention are listed in Table 3.

Vector DNA can be introduced into prokaryotic or eukaryotic cells by conventional transformation or transfection techniques. As used herein, the terms "transformation" and "transfection" are meant to refer to a variety of art-recognized techniques for transferring foreign nucleic acid (e.g., linear DNA or RNA (e.g., linear vectors or individual genetic constructs without vectors)) or nucleic acid in vector form (e.g., plasmids, phage, phagemids, transposons or other DNA) into a host cell, including calcium phosphate or calcium chloride co-precipitation, DEAE-dextran-mediated transfection, lipofection, or electroporation. Suitable methods for transforming or transfecting host cells can be found in Sambrook, et al (Molecular Cloning: A Laboratory Manual.2nd ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989), and other Laboratory manuals.

It is known that, for stable transfection of mammalian cells, only a small fraction of the exogenous DNA can be integrated into its own genome, depending on the expression vector and transfection technique used. To identify and screen for these integrants, a gene encoding a selectable marker (e.g., resistance to an antibiotic) is typically introduced into the host cell along with the gene of interest. Preferred selectable markers include those that confer drug resistance, such as G418, hygromycin and methotrexate. The nucleic acid encoding the selectable marker may be introduced into the host cell on the same vector as the MP protein, or on a separate vector. Cells stably transfected with the introduced nucleic acid can be identified using drug selection (e.g., cells that incorporate a selectable marker gene can survive, while other cells die).

To create a homologous recombinant microorganism, a vector is prepared containing at least a portion of the MP gene, which has been deleted, added, or substituted to thereby alter, e.g., functionally disrupt, the MP gene. This is preferably the MP gene from C.glutamicum, but it may also be a homologue from a related bacterium, even from mammals, yeasts or insects. In a preferred embodiment, the vector is designed such that the endogenous MP gene is functionally disrupted upon homologous recombination (i.e., not encoding a functional protein; also referred to as a "knock-out" vector). In addition, the vector may be designed such that the endogenous MP gene is mutated or altered upon homologous recombination, but still encodes a functional protein (e.g., an upstream regulatory region is altered, thereby altering expression of the endogenous MP gene). In the homologous recombination vector, the altered MP gene portion is flanked at its 5 'and 3' ends by excess MP nucleic acid, such that homologous recombination can occur between the exogenous MP gene carried by the vector and the endogenous MP gene of the microorganism. The excess flanking MP nucleic acid is of sufficient length to allow successful homologous recombination with the endogenous gene. Typically, vectors contain several kilobases of side chain DNA (both at the 5 'and 3' ends) (see, e.g., Thomas, K.R., and Capcochi, M.R, (1987) Cell 51: 503 for a description of homogous recombination vectors). Vectors for introduction into microorganisms (e.g., electroporation) and cells, those in which the introduced MP gene is homologous to the endogenous MP gene are selected, and homologous recombination is possible using techniques known in the art.

In another embodiment, a recombinant microorganism can be produced that contains a selected system that allows for the regulation of the expression of the introduced gene. For example, the MP gene is included in the vector under the control of the lac operon, such that the MP gene can only be expressed in the presence of IPTG. Such regulation systems are well known in the art.

In another embodiment, the endogenous MP gene in the host cell is disrupted (e.g., by homologous recombination or other genetic methods known in the art) such that expression of its protein product cannot occur. In another embodiment, the endogenous or introduced MP gene in the host cell is altered by one or more point mutations, deletions or inversions, but still encodes a functional MP protein. In yet another embodiment, one or more regulatory regions (e.g., promoters, repressors, or inducers) of a microbial MP gene are altered (e.g., by deletion, splicing, inversion, or point mutation) such that expression of the MP gene is modulated. Those skilled in the art will appreciate that host cells containing more than one such MP gene and protein modification can be readily produced using the methods of the present invention and are also encompassed by the present invention.

Host cells of the invention, such as cultured prokaryotic or eukaryotic host cells, can be used to produce (e.g., express) MP proteins. Thus, the present invention further provides methods for producing MP proteins using the host cells of the invention. In one embodiment, the method comprises culturing a host cell of the invention (into which a recombinant expression vector encoding an MP protein has been introduced, or into the genome of which a gene encoding a wild-type or altered MP protein has been introduced) in a suitable medium until an MP protein is produced. In another embodiment, the method further comprises isolating the MP protein from the culture medium or the host cell.

C. Isolated MP proteins

Another aspect of the invention relates to isolated MP proteins and biologically active portions thereof. An "isolated" or "purified" protein, or biologically active portion thereof, is substantially free of cellular material when produced using recombinant DNA techniques and substantially free of chemical precursors or other chemicals when chemically synthesized. The term "substantially free of cellular material" includes preparations of MP proteins in which the protein is isolated from cellular components of the cell in which the protein is naturally or recombinantly produced. In one embodiment, the term "substantially free of cellular material" includes preparing an MP protein containing at least about 30% (by dry weight) non-MP protein (also referred to herein as "contaminating protein"), more preferably containing less than about 20% non-MP protein, even more preferably containing less than about 10% non-MP protein, and most preferably containing less than about 5% non-MP protein. When the MPprotein or biologically active portion thereof is recombinantly produced, it is preferably substantially free of culture medium, i.e., culture medium is less than about 20%, preferably less than 10%, and most preferably less than about 5% of the volume of protein produced. The term "substantially free of chemical precursors or other chemicals" includes MP protein preparations in which the protein is separated from chemical precursors or other chemicals that are involved in protein synthesis. In one embodiment, the term "substantially free of chemical precursors or other chemicals" includes preparing an MP protein containing at least about 30% (by dry weight) of chemical precursors or non-MP chemicals, more preferably containing less than about 20% of chemical precursors or non-MP chemicals, even more preferably containing less than about 10% of chemical precursors or non-MP chemicals, and most preferably containing less than about 5% of chemical precursors or non-MP chemicals. In a preferred embodiment, the isolated protein, or biologically active portion thereof, does not contain contaminating proteins from the same organism from which the MP protein was obtained. Such proteins are typically produced by recombinant expression, for example, of the MP protein of C.glutamicum in microorganisms such as C.glutamicum.

An isolated MP protein of the invention, or a biologically active portion thereof, is capable of catalyzing an enzymatic reaction in an amino acid, vitamin, trophic factor, nucleotide, nucleoside, or trehalose metabolic pathway or has one or more of the activities listed in table 1. In a preferred embodiment, the protein or portion thereof comprises an amino acid sequence that is sufficiently homologous to an amino acid sequence of the present invention (e.g., one of the even-numbered SEQ ID NOs of the sequence Listing) such that the protein or biologically active portion thereof catalyzes an enzymatic reaction in an amino acid, vitamin, cofactor,trophic factor, nucleotide, nucleoside, or trehalose metabolic pathway. The portion of the protein preferably refers to a biologically active portion as described herein. In another preferred embodiment, the MP protein of the present invention has the amino acid sequence as listed as an even-numbered sequence number in the sequence listing. In another preferred embodiment, the MP protein has an amino acid sequence encoded by a nucleotide sequence that hybridizes, e.g., under stringent conditions, to a nucleotide sequence of the present invention (e.g., one of the odd-numbered sequence numbers in the sequence listing). In another preferred embodiment, the MP protein has an amino acid sequence encoded by a nucleotide sequence that is at least about 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, or 60% homologous, preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70% homologous, more preferably at least about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 88%, 89%, or 90%, or 91%, 92%, 93%, 94%, and even more preferably at least about 95%, 96%, 97%, 98% homologous to a nucleic acid sequence of the invention, or portion thereof, 99% or more homology. Ranges or values of identity between the values recited above (e.g., 70-90% identity or 80-95% identity) are also intended to be encompassed by the present invention. For example, it is intended to include such ranges of consistency values as are combinations of the upper and/or lower limits recited above. Preferred MP proteins of the invention also preferably have at least one MP activity as described herein. For example, a preferred MP protein of the invention comprises an amino acid sequence encoded by a nucleotide sequence that hybridizes, e.g., under stringent conditions, to a nucleotide sequence of the invention and that is capable of catalyzing an enzymatic reaction in an amino acid, vitamin, cofactor, trophic factor, nucleotide, nucleoside, or trehalose metabolic pathway or has one or moreof the activities listed in Table 1.

In other embodiments, the MP protein has substantial homology to the amino acid sequence of the invention (e.g., one of the sequences set forth as even-numbered SEQ ID NOs of the sequence Listing), and has the functional activity of the amino acid sequence protein of the invention, as described in detail in section I above, which differs in amino acid sequence by natural alteration or mutation. Thus, in another embodiment, an MP protein is a protein having an amino acid sequence that is at least about 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, or 60% homologous, preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70% homologous, more preferably at least about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 88%, 89%, or 90% homologous to the complete amino acid sequence of the invention, or 91%, 92%, 93%, 94%, and even more preferably at least about 95%, 96%, 97%, 98%, 99% or more homology, and having at least one MP activity as described herein. Ranges or values of identity between the values recited above (e.g., 70-90% identity or 80-95% identity) are also intended to be encompassed by the present invention. For example, it is intended to include such ranges of consistency values as are combinations of the upper and/or lower limits recited above. In another embodiment, the invention relates to a full-length Corynebacterium glutamicum protein which has substantial homology to the amino acid sequences of the present invention.

Biologically active portions of an MP protein comprise polypeptides comprising an amino acid sequence derived from an amino acid sequence of an MP protein, e.g., an amino acid sequence of an even-numbered sequence number of the sequence listing or an amino acid sequence of a protein homologous to an MP protein, that comprise fewer amino acids than a full-length MP protein or a full-length MP protein homologous protein, and that exhibit at least one MP protein activity. Typically, a biologically active moiety (a peptide, e.g., a peptide having an amino acid length such as 5, 10, 15, 20, 30, 35, 36, 37, 38, 39, 40, 50, 100 or more) includes a domain or motif having at least one MP protein activity. In addition, other biologically active portions, in which other portions of the protein have been deleted, can be prepared by recombinant techniques and identified for one or more of the activities described herein. The biologically active portion of the preferred MP proteins comprises one or more selected biologically active domains/motifs or parts thereof.

The MP proteins are preferably produced by recombinant DNA techniques. For example, a nucleic acid molecule encoding a protein is cloned into an expression vector (as described above), the expression vector is introduced into a host cell (as described above) and the MP protein is expressed in the host cell. The MP protein is then isolated from the cells according to a suitable purification scheme using standard protein purification techniques. In addition to recombinant expression, MP proteins, polypeptides, or peptides can be chemically synthesized using standard peptide synthesis techniques. Alternatively, native MP protein may be isolated from cells (e.g., endothelial cells), e.g., using anti-MP antibodies, which may be produced by standard techniques using MP proteins of the invention or portions thereof.

The invention also provides MP chimeric proteins or fusion proteins. As used herein, an MP "chimeric protein" or "fusion protein" comprises an MP polypeptide operably linked to a non-MP polypeptide. "MP polypeptide" refers to a polypeptide comprising an MP-related amino acid sequence, and "non-MP protein" refers to a polypeptide comprising an amino acid sequence related to a protein that has no substantial homology to an MP protein, e.g., a protein from the same or a different organismthan an MP protein. In fusion proteins, the term "operably linked" means that the MP protein and the non-MP protein are in frame fused to each other. The non-MP polypeptide may be fused to the N-terminus or C-terminus of the MP polypeptide. For example, in one embodiment, the fusion protein is a DST-MP fusion protein in which the MP sequence is fused to the C-terminus of the GST sequence. The fusion protein facilitates the purification of recombinant MP proteins. In another embodiment, the fusion protein is an MP protein having a heterologous signal sequence at its N-terminus. In certain host cells (e.g., mammalian host cells), expression and/or secretion of MP proteins may be increased through the use of heterologous signal sequences.

Preferably, the chimeric or fusion proteins of the invention are produced by standard recombinant DNA techniques. For example, DNA fragments encoding different polypeptide sequences are ligated together in frame according to conventional techniques, e.g., end-joining using blunt-ended or staggered ends, digestion with restriction enzymes to provide suitable ends, filling in with cohesive ends as suitable ends, treatment with alkaline phosphatase to avoid undesirable ligation, and enzymatic ligation. In another embodiment, the fusion gene may be synthesized using conventional techniques including automated DNA synthesizers. In addition, PCR amplification of gene fragments can be performed using anchor primers that can add complementary overhangs between two consecutive gene fragments, which can then be annealed and reamplified to generate a chimeric gene sequence (see, e.g., Current Protocols in molecular Biology, eds. Ausubel et al. John Wiley&Sons: 1992). In addition, many expression vectors are commercially available that already encode a fusion moiety (e.g., a GST polypeptide). The MP-encoding nucleic acid can be cloned into such an expression vector such that the fusion moiety is linked in-frame to the MP protein.

Homologues of MP proteins can be produced by mutation, such as mutation or cleavage of a discontinuity in the MP protein. As used herein, the term "homolog" refers to a variant form of the MP protein that can act as an agonist or antagonist of MP protein activity. An agonist of an MP protein can have substantially the same or partial biological activity of the MP protein. Antagonists of MP proteins can inhibit one or more activities of the naturally occurring form of the MP protein, e.g., by competing binding to downstream or upstream members of the MP system comprising the MP protein. Thus, the MP protein from Corynebacterium glutamicum and the homologues thereof of the present invention may modulate the activity of one or more carbohydrate transport pathways or the activity of intracellular signaling pathways in which MP proteins function in this microorganism.

In additional embodiments, homologues of MP protein can be used to identify MP protein agonist or antagonist activity by screening combinatorial libraries of MP protein mutants, such as splice mutants. In one embodiment, a diverse library of MP variants is generated by combining mutations at the nucleic acid level and encoded by a diverse gene library. A diverse library of MP variants can be expressed, for example, by enzymatically ligating a mixture of synthetic oligonucleotides into the gene sequences such that a degenerate collection of potential MP sequences is expressed as a single polypeptide, or a collection of larger fusion proteins (e.g., for phage display) containing a collection of MP sequences. Various methods are available for generating libraries of potential MP homologs from concatemeric oligonucleotide sequences. Chemical synthesis of a degenerate gene sequence can be performed using an automated DNA synthesizer, and the synthetic gene can then be ligated into a suitable expression vector. The use of a degenerate set of genes allows for the mixing of all sequences that provide the set of sequences encoding the desired potential MP. Methods for synthesizing degenerate oligonucleotides are known in the art (see, e.g., Narang, S.A. (1983) Tetrahedron 39: 3; Itakura et al (1984) Annu. Rev. biochem.53: 323; Itakura et al (1984) Science 198: 1056; Ike et al (1983) Nucleic Acid Res.11: 477).

In addition, libraries encoding MP protein fragments can be used to generate a diverse population of MP fragments that are used to screen and select for homologues of MP proteins. In one embodiment, a library of coding sequence fragments may be generated by treating double stranded PCR fragments of MP coding sequences with a nuclease under conditions that produce only about one nick per molecule, denaturing the double stranded DNA, renaturing the DNA to form double stranded DNA, which may comprise sense/antisense pairs formed from different nicked products, removing single stranded portions in the reformed duplex by S1 nuclease treatment, and ligating the resulting library of fragments into an expression vector. By this method, expression libraries encoding N-terminal, C-terminal and intermediate fragments of MP proteins of different sizes can be obtained.

Many techniques for screening gene products from combinatorial libraries, derived from point mutations or splicing, and for screening cDNA libraries for gene products having selected properties are known in the art. These techniques are all applicable to the rapid screening of gene libraries derived from combinatorial mutations of MP homologues. The most widely used techniques for screening large gene libraries can be used for high-throughput analysis, including cloning of genomic libraries into replicable expression vectors, transforming the vector libraries with the resulting vector libraries, and expressing combinatorial genes under conditions where detection of the desired activity facilitates isolation of the vector encoding the gene to be detected.Regression Ensemble Mutation (REM), a novel technique to increase the frequency of functional mutants in libraries, can be used in conjunction with screening assays to identify MP homologs (Arkin and Yourvan (1992) PANS 89: 7811. sup. 7815; Delgrave et al (1993) Protein Engineering 6 (3): 327. sup. 331).

In another embodiment, cell-based assays can be used to analyze diverse MP libraries using methods known in the art.

D. Applications and methods of the invention

The nucleic acid molecules, proteins, protein homologues, fusion proteins, primers, vectors and host cells described herein may be used in one or more of the following methods: identifying corynebacterium glutamicum and a related microorganism; drawing a genome map of a corynebacterium glutamicum related organism; identifying and locating a sequence of interest from Corynebacterium glutamicum; evolution research; determining functionally essential regions of the MP protein; modulation of MP protein activity; MP pathway activity modulation; modulation of the cellular production of a desired compound, for example a fine chemical.

The MP nucleic acid molecules of the invention have various uses. First, they can be used to identify whether an organism is Corynebacterium glutamicum or its close relatives. They can also be used to identify the presence of corynebacterium glutamicum or its related organisms in mixed microbial populations. The present invention provides nucleic acid sequences of a plurality of genes of Corynebacterium glutamicum; the presence of this organism can be determined by probing genomic DNA extracted from cultures of single or mixed microorganisms under stringent conditions with probes spanning the gene specific for C.glutamicum. Although Corynebacterium glutamicum itself is nonpathogenic, it is associated with pathogenic species, such as Corynebacterium diphtheriae. Corynebacterium diphtheriae is the causative agent of diphtheria, a rapidly developing, acute, febrile infection that is implicated in both local and systemic pathologies. In this disease, the upper respiratory tract is locally diseased and includes necrotic damage to epithelial cells; the bacteria secrete toxins, which spread from the lesion to the body's susceptible peripheral tissues. These tissues include the heart, muscle, peripheral nerves, adrenal gland, kidney, liver and spleen, where degenerative changes due to the inhibition of protein synthesis lead to systemic pathology of the disease. Diphtheria remains a high incidence in many areas of the world, including africa, asia, eastern europe, and independent countries of the former soviet union. The continued prevalence of diphtheria in the latter two areas has resulted in at least 5,000 deaths since 1990.

In one embodiment, the invention relates to a method of identifying the presence or activity of corynebacterium diphtheriae in a subject. The method comprises identifying one or more nucleic acid or amino acid sequences of the invention (e.g., odd or even sequence numbers listed in the sequence listing, respectively) in the subject, thereby detecting the presence or activity of corynebacterium diphtheriae in the subject. Corynebacterium glutamicum and Corynebacterium diphtheriae are related bacteria, and many of the nucleic acid and protein molecules in Corynebacterium glutamicum are homologs of the nucleic acid and protein molecules in Corynebacterium diphtheriae, and thus can also be used to detect Corynebacterium diphtheriae in a subject.

The nucleic acid and protein molecules of the invention may also be used as markers for specific regions of the genome. This is useful not only for mapping the genome but also for studying the function of proteins in Corynebacterium glutamicum. For example, to identify the genomic region to which a particular C.glutamicum DNA binding protein binds, the C.glutamicum genome may be digested and the fragments incubated with the DNA binding protein. Fragments that bind to a protein can be further probed with the nucleic acid molecules of the invention, preferably using a readily detectable label; the binding of these nucleic acid molecules to genomic fragments allows the localization of the fragments on the genomic map of C.glutamicum and, when performed several times with different enzymes, facilitates the rapid determination of the nucleic acid sequence to which the protein binds. In addition, the nucleic acid molecules of the invention may have sufficient homology to related species such that these nucleic acid molecules may serve as markers for constructing a genomic map of related bacteria, such as Brevibacterium lactofermentum.

The MP nucleic acid molecules of the invention can in turn be used for evolution and protein structure studies. The carbohydrate uptake system in which the molecule of the present invention participates is used by various bacteria; by comparing the sequences of the nucleic acid molecules of the invention with those which encode similar enzymes in other organisms, it is possible to estimate the evolutionary relatedness of the organisms. Similarly, this comparison allows the estimation of conserved sequence regions and non-conserved sequence regions, which may help in determining regions of the protein that are essential for enzyme function. This type of determination is valuable for protein engineering studies and may indicate that those proteins can tolerate mutations without losing function.

Manipulation of the MP nucleic acid molecules of the invention can result in the production of MP proteins having different functions than wild-type MP proteins. The efficiency or activity of these proteins can be increased, can be made to occur in greater numbers in the cell than usual, or can be reduced.

The invention also provides methods of screening for molecules that modulate the activity of an MP protein, either by interacting with the protein itself or a substrate, or by binding to a partner of the MP protein, or by modulating transcription or translation of an MP nucleic acid molecule of the invention. In this method, a microorganism expressing one or more MP proteins is contacted with one or more test compounds, and the effect of each test compound on MP protein activity or expression level is assessed.

When the desired fine chemical to be isolated from a large-scale fermentation culture of C.glutamicum is an amino acid, a vitamin, a cofactor, a trophic factor, a nucleotide, a nucleoside or trehalose, modulation of the efficiency or activity of one or more proteins of the invention by recombinant genetic mechanisms can directly influence one of these fine chemicals. For example, for an enzyme in the biosynthetic pathway of a desired amino acid, an increase in the activity or efficiency of the enzyme (including the presence of multiple copies of the gene) should result in the production or efficiency of production of the desired amino acid. For enzymes in the biosynthetic pathway of amino acids whose synthesis competes with the biosynthesis of the desired amino acid, a decrease in this enzymatic activity or efficiency (including gene deletion) results in an increase in the production or efficiency of production of the desired amino acid due to a decrease in competition for intermediate compounds and/or energy. For enzymes of the desired amino acid degradation pathway, this reduction in enzyme activity or efficiency results in higher yields or production efficiencies of the desired product due to reduced degradation thereof. Finally, mutagenesis of the enzyme involved in the biosynthesis of the desired amino acid is carried out such that the enzyme is no longer feedback-inhibited, which leads to an increase in the yield or production efficiency of the desired amino acid. The same is true for the biosyntheticand degradative enzymes associated with the metabolism of vitamins, cofactors, trophic factors, nucleotides, nucleosides, and trehalose of the present invention.

Similarly, when the desired fine chemical is not one of the above-mentioned compounds, it is still possible that the modulation of the activity of a protein according to the invention may affect the efficiency and/or the yield of the large-scale production of this compound in Corynebacterium glutamicum. The metabolic pathways of any organism are closely related, and intermediates used in one pathway are often supplied by different pathways. Enzyme expression and function can be regulated at the cellular level of different metabolic process compounds, and cellular levels of molecules such as amino acids and nucleotides necessary for basal production have a significant impact on microbial viability in large-scale culture. Thus, modulation of an amino acid biosynthetic enzyme such that it no longer responds to feedback inhibition or its efficiency or conversion is increased results in an increase in the cellular level of one or more amino acids. As a result, this increased supply of amino acids not only increases the supply of molecules essential for protein synthesis, but also increases the supply of molecules that are used as intermediates and precursors in a variety of other biosynthetic pathways. If the specific amino acids within the cell are limited, increasing their production will also increase the ability of the cell to perform a variety of other metabolic reactions and allow the cell to produce various proteins more efficiently, potentially increasing the overall production rate or viability of the cell in large-scale culture. The increased viability increases the number of cells in the fermentation culture that are capable of producing the desired fine chemical, thereby increasing the yield of the compound. Similar situations may exist by adjusting the degrading enzyme activity of the invention such that the enzyme no longer catalyzes the degradation or catalytic efficiency of cellular compounds that are important for the biosynthesis of the desired compound, or that are more effective for cell growth and proliferation in large-scale cultures. It should be emphasized that optimizing the degrading activity or reducing the biosynthetic activity of certain molecules of the invention may also have a positive effect on the production of certain fine chemicals by C.glutamicum. For example, more intermediates may be used for the conversion of a desired substance by reducing the efficiency of the activity of biosynthetic enzymes in pathways that compete with the biosynthetic pathway for one or more intermediates of the desired compound. Similarly, it may be desirable to increase the degradation capacity or efficiency of one or more proteins of the invention.

The aforementioned list of MP protein mutagenesis protocols that result in increased production of the desired compound is not meant to be limiting; variations of these mutagenesis schemes will be readily apparent to those of ordinary skill in the art. By these mechanisms, the nucleic acid and protein molecules of the invention can be used to produce Corynebacterium glutamicum or related strains thereof expressing mutant MP nucleic acid and protein molecules, thereby increasing the yield, production, and/or efficiency of production of the desired compound. The desired compound may be any natural product of C.glutamicum, including end products of biosynthetic pathways and intermediates of naturally occurring metabolic pathways, and molecules which do not occur naturally in the metabolism of C.glutamicum but are produced by the C.glutamicum strains of the present invention.

The invention is further illustrated by the following examples, which should not be construed as limiting. The contents of all references, patent applications, patents, published patent applications, tables and sequencelistings cited in this application are incorporated by reference in their entirety.

Table 1: the amino acid numbering OF the amino acid numbering contig OF the LYSINE biosynthetic nucleic acids OF the genes INVOLVED begins the NT termination function SEQ ID NO, 12 RXA02229 GR 0065327933617 DIAMINOPIPIATE EPIMERASE (EC 5.1.1.7) 34 RXS02970 ACYLONITHINE AMINOTRANSFERE (EC 2.6.1.11) 56F RXA01009 GR 0028747145943 ACETYLONITHINE AMINOTRANSFERE (EC 2.6.1.11) 78 RXC02390 MEMBRANE SPANNING PROTEIN INVOLVELVED IN LYSINE METABOLISM 910 RXC01796 MBOLINE ASSOCIATED PROTEIN INVOLED IN METABOLISM 1112C 01207 CYCLONIC PROTEIN INVOLATED IN METABOLISM LYSINE AND

(IV) THREONINE 1314 RXC00657 TRANSCRIPTION REGUILATOR INVOLVED IN LYSINE METABOLISM 1516 RXC00552 CYTOSOL PROTEIN INVOLVEOL IN LYSINE METABOLISM TREHALOSE nucleic acid amino acid numbering contig NT INITIATING NT TERMINATION FUNCTION SEQ ID NO 1718 RXN00351 VV 01353707838532 ALPHA, ALPHA-TREHINE PHOSPSYNHATE THASE (UDP FOURING) KD 56 KD

SUBUNIT(EC 2.4.1.15)19 20 F RXA00351 GR00066 1486 2931 ALPHA，ALPHA-TREHALOSE-PHOSPHATE SYNTHASE(UDP-FORMING) 56 KD

SUBUNIT (EC 2.4.1.15) 2122 RXA00873 GR 002413758 trehalose synthsase (EC 2.4.1.-) 2324 RXA00691 GR 0024310054 trehalose synthsase (EC 2.4.1.-) lysine biosynthetic nucleic acid amino acid number contig NT Start NT termination function SEQ ID NO 2526 RXA00534 GR 00137583496 ASPARTKINASE ALPHA BETA SUBUNITS (EC 2.7.2.4) 2728 RXA00533 GR 00134692438 ASPARTATE-SEMIALDEHYDE DEHYDROGENASE (EC 1.2.1.11) 2930A 02843 GR 00254342, 3, 4, 5-TETRAHYDROCARBIDE-2-BOXYLATE N-SUCCPYFERASRASE

(EC 2.3.1.117)31 32 RXA02022 GR00613 2063 3169 SUCCINYL-DIAMINOPIMELATE DESUCCINYLASE(EC 3.5.1.18)33 34 RXA00044 GR00007 3458 4393 DIHYDRODIPICOLINATE SYNTHASE(EC 4.2.1.52)35 36 RXA00863 GR00236 896 1639 DIHYDRODIPICOLINATE REDUCTASE(EC 1.3.1.26)37 38 RXA00864 GR00236 1694 2443 probable 2，3-dihydrodipicolinate N-C6-lyase(cyclizing)(EC 4.3.3.-)-

Corynebacterium glutamicum39 40 RXA02843 GR00842 543 4 2，3，4，5-TETRAHYDROPYRIDINE-2-CARBOXYLATE N-SUCCINYLTRANSFERASE

(EC 2.3.1.117)41 42 RXN00355 VV0135 31980 30961 MESO-DIAMINOPIMELATE D-DEHYDROGENASE43 44 F RXA00352 GR00068 861 4 MESO-DIAMINOPIMELATE D-DEHYDROGENASE(EC 1.4.1.16)

TABLE 1 (continuation) nucleic acid amino acid numbering contig NT initiating NT termination function SEQ ID NO SEQ ID NO 4546 RXA00972 GR 0027431379 DIAMINOPIPIATE DECARBOXYLASE (EC 4.1.1.20) 4748 RXA02653 GR 0075252377234 DIAMINOPIPIATE DECARBOXYLASE (EC 4.1.1.20) 4950 RXA01393 GR 0040842380 LYSINE EXPORT REGULATOR PROTEIN 5152 RXA00241 GR 0003654436945L-LYSINE TRANSPORT PROTEIN 5354A RXA GR 084320501018 LYSINE EXPORTER PROTEIN 5556A 00865 00236473549 DIHYDRODIPHICINOLIC PROTEIN (EC 4.2.1.52) 5758 RXS 020212, 4, 5-TETRADIDINE-2-LTRIPYBOXYLASE-2-LTRANE C-SUYLARBOXYLASE

(EC 2.3.1.117)59 60 RXS02157 ACETYLORNITHINE AMINOTRANSFERASE (EC 2.6.1.11)61 62 RXC00733 ABC TRANSPORTER ATP-BINDING PROTEIN INVOLVED IN LYSINE

METABOLISM63 64 RXC00861 PROTEIN INVOLVED IN LYSINE METABOLISM65 66 RXC00866 ZN-DEPENDENT HYDROLASE INVOLVED IN LYSINE METABOLISM67 68 RXC02095 ABC TRANSPORTER ATP-BINDING PROTEIN INVOLVED IN LYSINE

METABOLISM 6970 RXC03185 PROTEIN INVLVED IN LYSINE METABOLISM GLUTAMATE and Glutamine metabolizing nucleic acid amino acid numbering juxtaposition group NT initiating NT termination function SEQ ID NO SEQ ID NO 7172 RXN00367 Vh 0196974414273 GLUTAMATE SYNTHESE [ NADH]PRECURSOR (EC 1.4.1.14) 7374 FRXA00007 GR 00001718912 GLUTAMATE (NADPH) LARGE CHAIN PRECURSOR (EC 1.4.1.13) 7576 FRXA 00300364 GR 0007412964 GLUTAMATE SYNTHESE (NADPH) LARGE CHAIN PRECURSOR (EC 1.4.1.13) 7778 FRXA00367 GR 75699 GLUTAMATE SYN THATE (NADPH) LARGE CHAIN PRECURSOR (EC 1.4.1.13) 7980 RXN00076 VW 0154414141414122 GLUTAMATE, (NADPH) SYN 82824780GYD 7980 SYN 000513246 NADPH 51 SYN 3246 NADPH 51 SYN 51 SYNAMATE (NADPH) SYN 325935) SYN SAT 718998) NADPH 5935 NADPH 3651 SYN 3246 NADPH 5935 NADPH 5932 NADPH 52 SYN 5935 NADPH 5932 SYN 5935 NADPH 5932 SYN 5935 (NADPH 5932) SYN 5935 NADPH 5932 SYN 5935 NADPH 5935 (EC 1.4.1.13) 9192 RXA00366 GR 00075961605 GLUTAMATE SYNTHESE (NADPH) SMALL CHAIN (EC 1.4.1.13) 9394 RXA02072 GR 0062592599 NADP-SPECIFIC GLUTAMATE DEHYDRIGENASE (EC 1.4.1.4) 9596 RXA00323 GR 0005738555192 GLUTAMINE SYNTHESE (EC 6.3.1.2) 9798 RXA00335 GR 000578017757757750 GLUTAMINE SYNTHESE (EC 6.3.1.2) 99100 RXA00324 GR 00057526296 GLUTAMATE MONAMIA-LIGASE ADENYLYLTRANSFERASE (EC 2.7.7.42) 101102N 03176 VVVV03322033862 GLUTAMASE (EC 3.5.1.2) 103104F RXA GR 0005700057001862 GLUTAMATE GLUTAMASE (EC 3.5.1.2) 105106 RXA GR 00243002430024310747 GLUTAMATE-GLUTAMATE 2210721531 GLUTAMATE

TABLE 1 (continuation) alanine and ASPARTATE and asparagine metabolizing nucleic acid amino acid numbering juxtaposition group NT initiation function SEQ ID NO SEQ ID NO 109110 RXA02139 GR 00639674901 (GLUTAMINE-HYDROLYZING) (EC) 111112 RXN00116 VV 010975814 (EC 2.6.1.1) F RXA00116 GR 000185104 (EC 2.6.1.1) RXN00618 VVVQ 01102889182 (EC 2.6.1.1) F RXA 18 GR 00163746 (EC 2.6.1.1) F A00627 GR 0016441138 (EC 2.6.1.1) RXGR 020070200702007020070253350073500731 GR 3500751 GR 35353500751 GR1 (Asp 2.2.2.2 GR 01051 GR 35353592-98 GR 1- (Asp-WO 2.2.2.6.1.1) FXP A accession No. 15-WO 2-Asp accession No. 15-WO 2-WO 25, preferably No. 15, WO 2, WO 1, WO 1.4, WO 1, WO 5, WO 1, No.4, WO 1, WO

TABLE 1 (CONTINUOUS) THREONINE-metabolizing nucleic acid amino acid numbering contig NT initiating NT termination function SEQ ID NO SEQ ID NO 169170 RXN00969 VV 01491205313387 HOMESERINE DEHYDROGENASE (EC 1.1.1.3) 171172F RXA00974 GR 0027426233015 HOMELINE DEHYDROGENASE (EC 1.1.1.3) 173174 RXA00970 GR 002731087 HOMELINE KINASE (EC 2.7.1.39) 175176 RXA00330 GR 0005712968110THRONE SYNTHESE (EC 4.2.99.2) 177178 RXN00403 VV 00867004168911 HOMELINE O-ACETYLTRANSFERASE 179180 2 9180F RXA00403 GR 000GR 887231HOMELINE O-ACETYLTRANSFERASE (EC 2.3.1.11) 181182 RXC 07 CYOLIC VOOLINE NEIN OF LYSINE AND

The amino acid numbering juxtaposition of THRONINE 183184 RXC00152 MEMBRANE ASSOCIATED PROTEIN INVLVED IN THRONINE METABOLISM methionine and S-adenosylmethionine metabolizing nucleic acid the contig NT initiating function SEQ ID ND SEQ ID NO 185186 RXA00115 GR 000175949494313 HOMOTHERINE O-ACETYLTRANSFERASE (EC 2.3.1.31) 187188 RXN00403 VV 00700416841911 OSERANE O-ACETYLTRANSFERASE 189190F RXA00403 GR 0007231HOMOTHERINE O-ACETYLTRANSFERASE (EC 031 2.3.1.11) 191192S 58 CYSTATHINE GAMMA-SYNTHESE (EC 4.2.99.9) 193194F A00254 GR 000384141414141811 CYTOCHE GAMMA-SYNTHESE (4.2.99.9) 39532 GR 3026859-26639-3219-SYNTHENE-0027980 SYNTHESE-707755 SYNTHENE 707755 SYNTHESE-70779 SYNTHESE-7080 (SYNTHENE-707776) SYNTHENE-SYNTHESE-707776.

SULFHYDRYLASE (EC 4.2.99.8)205 206 F RXA00402 GR00088 1 576 O-ACETYLHOMOSERINE SULFHYDRYLASE (EC 4.2.99.10)/O-ACETYLSERINE

SULFHYDRYLASE (EC 4.2.99.8)207 208 RXA00405 GR00089 3289 3801 O-ACETYLHOMOSERINE SULFHYDRYLASE (EC 4.2.99.10)/O-ACETYLSERINE

SULFHYDRYLASE (EC 4.2.99.8)209 210 RXA02197 GR00645 4552 4025 5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE METHYLTRANSFERASE

(EC 2.1.113)211 212 RXN02198 VV0302 9228 11726 5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE METHYLTRANSFERASE

(EC 2.1.1.13)213 214 F RXA02198 GR00646 2483 6 5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE METHYLTRANSFERASE

(EC 2.1.1.13)215 216 RXN03074 VV0042 2238 1741 S-ADENOSYLMETHIONINE：2-DEMETHYLMENAQUINONE

METHYLTRANSFERASE (EC 2.1 .-.-)217 218 F RXA02906 GR10044 1142 645 S-ADENOSYLMETHIONINE：2-DEMETHYLMENAQUINONE

METHYLTRANSFERASE (EC 2.1 .-.-)219 220 RXND0132 VV0124 3612 5045 ADENOSYLHOMOCYSTEINASE (EC 3.3.1.1)221 222 F RXA00132 GR00020 7728 7624 ADENOSYLHOMOCYSTEINASE (EC 3.3.1.1)

TABLE 1 (continuation) nucleic acid amino acid numbering contigs NT initiating NT termination function SEQ ID NO SEQ ID NO 223224F RXA01371 GR 0039823393634 adonylLHOMYSTENASE (EC 3.3.1.1) 225226 RXN 020855-MethylraHYDROPHORYLLORGLUTAMATE- -HOMOCTYSINE

METHYLTRANSFERASE (EC 2.1.1.14)227 228 F RXA02085 GR00629 3496 5295 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE

METHYLTRANSFERASE (EC 2.1.1.14)229 230 F RXA02086 GR00629 5252 5731 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE

METHYLTRANSFERASE (EC 2.1.1.14)231 232 RXN02648 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE

METHYLTRANSFERASE (EC 2.1.1.14)233 234 F RXA02648 GR00751 5254 4730 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE

METHYLTRANSFERASE (EC 2.1.1.14)235 236 F RXA02658 GR00752 14764 15447 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE

METHYLTRANSFERASE (EC 2.1.1.14)237 238 RXC02238 PROTEIN INVOLVED IN METABOLISM OF S-ADENOSYLMETHIONINE，PURINES

AND PANTOTHENATE239 240 RXC00128 EXPORTED PROTEIN INVOLVED IN METABOLISM OF PYRIDIMES AND

ADENOSYLLHOMOCYSTENES-ADENOSYLMETHIONINE (SAM) BIOSYNTHESIS NUCLEIC ACID INITIATION FUNCTION SEQ ID NO SEQ ID NO 241242 RXA02240 GR 0065471606380S-ADENOSYLMETHIONINE SYNTHETAE (EC 2.5.1.6) CYSTEINE CYSTEIC ACID NUCLEIC ACID NOTEST SEQ ID NO 243244 RXA00780 GR 0020619206192234 SERINE ACETYLTRANSFERASE (EC 2.3.1.30) 245246 RXA GR 002065501482 CYSTEINE SYNTHASE (EC 4.

SULFHYDRYLASE (EC 4.2.99.8)249 250 F RXA00402 GR00088 1 576 O-ACETYLHOMOSERINE SULFHYDRYLASE (EC 4.2.99.10)/O-ACETYLSERINE

SULFHYDRYLASE (EC 4.2.99.8)251 252 RXS00405 O-ACETYLHOMOSERINE SULFHYDRYLASE (EC 4.2.99.10)/O-ACETYLSERINE

SULFHYDRYLASE (EC 4.2.99.8)253 254 RXC00164 ABC TRANSPORTER ATP-BINDING PROTEIN INVOLVED IN CYSTEINE

METABOLISM255 256 RXC01191 ABC TRANSPORTER ATP-BINDING PROTEIN INVOLVED IN CYSTEINE

METABOLISM

TABLE 1 (continuation) valine, leucine and isoleucine nucleic ACID AMINO ACID numbering juxtaposition group NT initiating NT termination function SEQ ID NO SEQ ID NO 257258 RXA02646 GR 0075138562588 THREONINE DEHYDRATASE BIOSYNTHEETIC (EC 4.2.1.16) 259260 RXA00766 GR 0020450914249 NCHED-CHAIN AMINO ACID AMINORANSFERASE (EC 2.6.1.42) 261262 RXYN 01690 V024616196 BRANCHED-CHAIN AMINOACID AMINORANSFERASE (EC 2.6.1.42) 263264F RXA 01GR 0041241248196 NCBRAHED-CHAIN AMINOACID AMINODES PAS (OPGR 2.6.1.42) 265266N 0143901417175171133-PYPYROPYE 2-3656354664469-36469-PYLMAE 35469-3635469-YP 35469-PYLMAE 35469-3635469-YP 35469-YP-354611-YP-354611-354626A-YP-3535466432 (EC 2-3635729) YP-35466432-36354635-YP-3635466432-36354635-YP-3535353535469-YPE-YP-36353535353535469-363535469-3535353535469-36353535469-36357223 (4-YPE-3635729-YPE-36357223-YPE-3635729-YPE-3635729- 2-oxobaunate HYDROXYMETHYLTRANSFERASE (EC 2.1.2.11)

DECARBOXYLASE (EC 4.1.1.44) 281282F RXA01929 GR 00555276619603-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (EC 2.1.2.11) 283284 RXN01420 VV 012215584146434 "-MYCAROSYL ISOVERYL-COA TRANSFERASE (EC 2. -) 285286 RXS01145 KETOL-ACID REDUCTOSOMERASE (EC 1.1.1.86) 287288F RXA GR 0032110751530 KETOL-ACID REDUCTOMERASE (EC 1.1.1.86) arginine and proline metabolizing biosynthetic enzymes: nucleic acid amino acid numbering contig NT Start NT termination function SEQ ID NO SEQ ID NO 289290 RXA02375 GR 006891449223 GLUTAMATE 5-KINASE (EC 2.7.2.11) 291292 RXN02362 VV 021351623867 GAMMA-GLUTAMYL PHYTATE REDUCTASE (GPR) (EC 1.2.1.41) 293294F RXA02378 GR 0069062416 GAMMA-GLUTAMYL PHYTATE REDUCTASE (GPR) (EC 1.2.1.41) 295296F RXA02382 GR 0069124931894 GAMMA-GLUTAMYL PHYTAMYL REDUCTADUSE (GPR 1.2.1.41) 297298 RXA02499 GR 00788PYPOLINE-5-BOXYLATE REDUCTASE (EC 1.5.1.2) 299300S 02157 ACYLATRANITHINE AMETASE (EC 36023601011) RXYAMINE 36353535353535353535353535353594S 898S 0226S 3639-BOXYLATE RECTASE (EC 9631) No. 2S 360227S 360232S 3639E

Table 1 (pro) proline degrading enzymes: nucleic acid amino acid numbering contig NT initiating NT termination function SEQ ID NO 307308 RXN00023 VV 01276815864703 PROLINE DEHYDROGENASE (EC 1.5.99.8)/DELTA-1-PYRROLINE-5-

CARBOXYLATE DEHYDROGENASE (EC 1.5.1.12)309 310 F RXA00023 GR00003 2 454 PROLINE DEHYDROGENASE (EC 1.5.99.8)/DELTA-1-PYRROLINE-5-

CARBOXYLATE DEHYDROGENASE (EC 1.5.1.12)311 312 F RXA02284 GR00660 3028 5 PROLINE DEHYDROGENASE (EC 1.5.99.8)/DELTA-1-PYRROLINE-5-

Carboxylate DEHYDROGENASE (EC 1.5.1.12) 313314 RXC02498 PROTEIN IN unsaturated IN PROTEIN methylation 3-hydroxy-PROLINE synthesis: nucleic acid amino acid numbering contig NT initiation NT termination function SEQ ID NO 315316 RXA01491 GR 0042353374687 DNA FOR L-PROLINE 3-HYDROXYLASE, COMPLETE CDS ornithine, arginine and spermidine metabolizing enzymes: nucleic ACID AMINO ACID numbering contig NT initial NT termination function SEQ ID NO 317318 RXA02155 GR 0064019133076 GLUTAMATE N-ACETYLTRANSFERASE (EC 2.3.1.35)/AMINO-ACID

ACETYLTRANSFERASE (EC 2.3.1.1 )319 320 RXA02156 GR00640 3125 4075 ACETYLGLUTAMATE KINASE (EC 2.7.2.8)321 322 RXN02153 VV0122 14106 13327 N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATE REDUCTASE (EC 1.2.1.38)323 324 F RXA02153 GR00640 757 1536 N-ACETYLGLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE325 326 RXA02154 GR00640 1536 1826 N-ACETYLGLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE327 328 RXA02157 GR00640 4079 5251 ACETYLORNITHINE AMINOTRANSFERASE (EC 2.6.1.11)329 330 RXS02970 ACETYLORNITHINE AMINOTRANSFERASE (EC 2.6.1.11 )331 332 F RXA01009 GR00287 4714 5943 ACETYLORNITHINE AMINOTRANSFERASE (EC 2.6.1.11)333 334 RXA02158 GR00640 5268 6224 ORNITHINE CARBAMOYLTRANSFERASE (EC 2.1.3.3)335 336 RXA02160 GR00640 6914 8116 ARGININOSUCCINATE SYNTHASE (EC 6.3.4.5)337 338 RXN02162 VV0122 6683 5253 ARGININOSUCCINATE LYASE (EC 4.3.2.1)339 340 F RXA02161 GR00640 8180 8962 ARGININOSUCCINATE LYASE (EC4.3.2.1)341 342 F RXA02162 GR00640 8949 9611 ARGININOSUCCINATE LYASE (EC 4.3.2.1)343 344 RXA02262 GR00654 32291 33436 ORNITHINE CYCLODEAMINASE (EC 4.3.1.12)345 346 RXA00219 GR00032 19289 20230 SPERMIDINE SYNTHASE (EC 2.5.1.16)347 348 RXA01508 GR00424 12652 14190 SPERMIDINE SYNTHASE (EC 2.5.1.16)349 350 RXA01757 GR00498 2942 2142 PUTRESCINE OXIDASE (EC 1.4.3.10)351 352 RXA02159 GR00640 6231 6743 ARGININE HYDROXIMATE RESISTANCE PROTEIN353354 RXN02154 VV0122 13327 13037 N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATE REDUCTASE (EC 1.2.1.38)355 356 RXS00147 CARBAMOYL-PHOSPHATE SYNTHASE SMALL CHAIN (EC 6.3.5.5)357 358 RXS00905 N-ACYL-L-AMINO ACID AMIDOHYDROLASE (EC 3.5.1.14)359 360 RXS00906 N-ACYL-L-AMINO ACID AMIDOHYDROLASE (EC 3.5.1.14)

TABLE 1 (continuation) nucleic ACID AMINO ACID numbering juxtaposition to the group NT initiating NT terminating function SEQ ID N0 SEQ ID NO 361362 RXS 00907N-ACYL-L-AMINO ACID hydrochloride (EC 3.5.1.14) 363364 RXS 02001N-ACYL-L-AMINO ACID hydrochloride (EC 3.5.1.14) 365366 RXS 02101N-ACYL-L-AMINO ACID hydrochloride (EC 3.5.1.14) 367368 RXS02234 BACAROYL-PHOSPHATE SYNTHASE LARGE CHAIN (EC 6.3.5.5) 369370F RXS02234 0065413198 BAMOYL-PHOSPHATE SYNTHASE LARGE CHAIN (EC 6.3.5.5) 371372 RXS 02565N-ACYL-L-AMINO ACID hydrochloride (EC 0202176) nucleotide terminating group NT 4539027N-ACYL-L-AMINO ACID hydrochloride (EC 5358353194) nucleic ACID numbering juxtaposition to the group NT initiating NT terminating function SEQ ID NO SEQ ID NO 1N 0 RXS 02001N-ACYL-AMINO ACID hydrochloride (EC 02194) and SEQ ID NO accession number 45353194 EC 3.6.1.31) 379380 RXA01097 GR 0030647264373 PHOSPHORIBOSYL-AMP CYCLOHEIDROLASE (EC 3.5.4.19) 381382 RXA01100 GR 0030670726335 PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOL E CARBOXAMIDE

RIBOTIDE ISOMERASE (EC 5.3.1.16)363 384 RXA01101 GR00306 7726 7094 AMIDOTRANSFERASE HISH (EC 2.4.2.-)385 386 RXN01657 VV0010 39950 39351 AMIDOTRANSFERASE HISH (EC 2.4.2.-)387 388 F RXA01657 GR00460 2444 2944 AMIDOTRANSFERASE HISH (EC 2.4.2.-)389 390 RXA01098 GR00306 5499 4726 HISF PROTEIN391 392 RXN01104 VV0059 7037 6432 IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE (EC 4.2.1.19)393 394 F RXA01104 GR00306 10927 10322 IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE (EC 4.2.1.19)/

The nucleic acid sequence of HISTIDINOL-PHOSPHATASE (EC 3.1.3.15) 395396 RXN00446 VV 01122416123318 HISTIDINOL-PHOSPHATE AMINOSFERASE (EC 2.6.1.9) 397398F RXA00446 GR 001084525 HISTIDINOL-PHOSPHATE AMINOSFERASE (EC 2.6.1.9) 399400 RXA01105 GR 0030614107 HISTIDINODINOL-PHOSPHATE AMINOSE ERASE (EC 2.6.1.9) 401402 RXA01106 GR 003061337613 HISTIDINOL DEHYDAGENOSE (EC 1.1.1.23) 403404 RXANSC 00930 PROTEIN INNEXYGR 42 METHYLOSE 40545401096 PROTEXYGEN GR 2 METHYLIN 464635 ABSODE 354635 OBOSE No. (EC 354635) ABYTE × 354635-354635 × BENYP 354655 × 35354135 F RXA00957 GR 0026431130 ANTHRANILATE SYNTHASE COMPONENT I (EC 4.1.3.27)

TABLE 1 (continuation) nucleic acid amino acid numbering contig NT Start NT termination function SEQ ID NO SEQ ID NO 423424 RXA02687 GR 007541130610 CHORISMATE MUTASE (EC 5.4.99.5)/PREPHENATE DEHYDRATASE (EC 5.4.99.5)

4.2.1.51)425 426 RXN01698 VV0134 11507 12736 CHORISMATE SYNTHASE (EC 4.6.1.4)427 428 F RXA01698 GR00477 2 991 CHORISMATE SYNTHASE (EC 4.6.1.4)429 430 RXA01095 GR00306 3603 2821 INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE (EC 4.1.1.48)431 432 RXA00955 GR00263 586 2007 INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE (EC 4.1.1.48)/N-(5’-PHOSPHO-

RIBOSYL)ANTHRANILATE ISOMERASE (EC 5.3.1.24)433 434 RXA02814 GR00795 598 128 ISOCHORISMATE MUTASE435 436 RXA00229 GR00033 1715 936 SHIKIMATE 5-DEHYDROGENASE (EC 1.1.1.25)437 438 RXA02093 GR00629 12444 13247 SHIKIMATE 5-DEHYDROGENASE (EC 1.1.1.25)439 440 RXA02791 GR00777 6968 7795 SHIKIMATE 5-DEHYDROGENASE (EC 1.1.1.25)441 442 RXA01699 GR00477 984 1553 SHIKIMATE KINASE (EC 2.7.1.71)443 444 RXA00952 GR00262 97 936 TRYPTOPHAN SYNTHASE ALPHA CHAIN (EC 4.2.1.20)445 446 RXN00956 VV0247 1140 4 TRYPTOPHAN SYNTHASE BETA CHAIN (EC 4.2.1.20)447 448 F RXA00956 GR00263 2027 3157 TRYPTOPHAN SYNTHASE BETA CHAIN (EC 4.2.1.20)449 450 RXA00064 GR000102499 3776 TYROSINE AMINOTRANSFERASE (EC 2.6.1.5)451 452 RX N00448 VV0112 33959 32940 PREPHENATE DEHYDROGENASE (EC 1.3.1.12)453 454 F RXA00448 GR00109 3 668 PREPHENATE DEHYDROGENASE (EC 1.3.1.12)455 456 F RXA00452 GR00110 854 1099 PREPHENATE DEHYDROGENASE (EC 1.3.1.12)457 458 RXA00584 GR00156 11384 10260 PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE (EC 4.1.2.15)459 460 RXA00579 GR00156 5946 4087 PARA-AMINOBENZOATE SYNTHASE COMPONENT I(EC 4.1.3.-)461 462 RXA00958 GR00264 1130 1753 PARA-AMINOBENZOATE SYNTHASE GLUTAMINE AMIDOTRANSFERASE

COMPONENT II (EC 4.1.3.-)/ANTHRANILATE SYNTHASE COMPONENT II (EC

4.1.3.27)463 464 RXN03007 VV0208 3410 3778 ANTHRANILATE SYNTHASE COMPONENT II (EC 4.1.3.27)465 466 RXN02918 VV0086 25447 25887 TRYPTOPHAN SYNTHASE BETA CHAIN (EC 4.2.1.20)467 468 RXN01116 VV0182 7497 6886 3-OXOADIPATE COA-TRANSFERASE SUBUNIT B (EC 2.8.3.6)469 470 RXN01115 VV0182 10347 11099 3-OXOADIPATE ENOL-LACTONE HYDROLASE (EC 3.1.1.24)/4-

CARBOXYMUCONOL ACTONE471 472 RXS00116 ASPARTATE AMINOTRANSFERASE (EC 2.6.1.1)473 474 F RXA00116 GR00018 510 4 ASPARTATE AMINOTRANSFERASE (EC 2.6.1.1)475 476 RXS00391 O-SUCCINYLBENZOIC ACID-COA LIGASE (EC 6.2.1.26)477 478 RXS00393 1，4-DIHYDROXY-2-NAPHTHOATE OCTAPRENYLTRANSFERASE (EC 2.5.-.-)479 480 F RXA00393 GR00086 4030 4911 1，4-DIHYDROXY-2-NAPHTHOATE OCTAPRENYLTRANSFERASE (EC 2.5.-.-)481 482 RXS00446 HISTIDINOL-PHOSPHATE AMINOTRANSFERASE (EC 2.6.1.9)483 484 F RXA00446 GR00108 4 525 HISTIDINOL-PHOSPHATE AMINOTRANSFERASE (EC 2.6.1.9)485 486 RXS00618 ASPARTATE AMINOTRANSFERASE (EC 2.6.1.1)487 488 F RXA00618 GR00163 213 746 ASPARTATE AMINOTRANSFERASE (EC 2.6.1.1)489 490 F RXA00627 GR00164 854 1138 ASPARTATE AMINOTRANSFERASE (EC 2.6.1.1)491 492 RXS01105 HISTIDINOL-PHOSPHATE AMINOTRANSFERASE (EC 2.6.1.9)493 494 RXS02315 2-SUCCINYL-6-HYDROXY-2，4-CYCLOHEXADIENE-1-CARBOXYLATE

SYNTHASE/2-OXOGLUTARATE DECARBOXYLASE (EC 4.1.1.71)495 496 RXS02550 ASPARTATE AMINOTRANSFERASE (EC 2.6.1.1)497 496 RXS02319 NAPHTHOATE SYNTHASE (EC 4.1.3.36)499 500 RXS02908 O-SUCCINYLBENZOIC ACID-COA LIGASE (EC 6.2.1.26)501 502 RXS03003 ASPARTATE AMINOTRANSFERASE (EC 2.6.1.1 )503 504 RXS03026 3-DEHYDROQUINATE DEHYDRATASE (EC 4.2.1.10)

Table 1 (continuation) nucleic acid amino acid numbering contigs NT start NT termination function SEQ ID NO 505506 RXS 03074S-adonosyllmethionine: 2-DEMETHYLMENAQINONE

METHYLTRANSFERASE (EC 2.1.-.-)507 508 RXC01434 MEMBRANE SPANNING PROTEIN INVOLVED IN METABOLISM OF AROMATIC

AMINO ACIDS AND RIBOFLAVIN509 510 RXC02080 MEMBRANE SPANNING PROTEIN INVOLVED IN METABOLISM OF AROMATIC

AMINO ACIDS511 512 RXC02789 CYTOSOLIC PROTEIN INVOLVED IN METABOLISM OF AROMATIC AMINO

ACIDS513 514 RXC02295 MEMBRANE SPANNING PROTEIN INVOLVED IN METABOLISM OF AROMATIC

AMINO acid numbering of AMINO acid residues of AMINO ACIDS of contig NT initiation function SEQ ID NO 515515 RXN03063 VV 0035666169974-aminobutyate AMINOTRANSFERASE (EC 2.6.1.19) 517518 RXN02970 VV002146081 Acetyl AMINO acid AMINOTRANSFERASE (EC 2.6.1.11) 519520F RXA01009 GR 0028747145943 Acetyl AMINO acid AMINOTRANSFERASE (EC 2.6.1.11), vitamin-like substance (cofactor), trophic factor thiamine metabolic nucleic acid numbering of contig NT initiation function SEQ ID NO 521521525309 GR 353123123129411 GR glycosyltransferase GR 353535353531A 01019 GR 003699 GR0039 GR glycosyltransferase No. 003530109A 0033500331A 003350033500331 GR 3531 GR 323531A 00331A 003549A 00331 GR 3200331 GR 323500331A 3500331A glycosyltransferase No. 00335003413500331A 35003413531A 2.7.4.7) 543544 RXN01413 VV 00502730627905 PHOSPHOMEHYLYMIDINE KINASE (EC 2.7.4.7) 545546 RXN01617 VV 00502218722858 PHOSPHOMEHYLYMIDINE KINASE (EC 2.7.4.7) 547548F RXA01617 GR 004512616 PHOSPHOMEHYLYMIDINE KINASE (EC 2.7.4.7) 549550 RXS01807 PYRIXIMIDINE KINASE (EC 2.7.1.35) 551552 RXC01021 CYTOSOLIC KINASE INVOLLVLYSOLVIN METABOLISM OF SUGARS AND THIAMIN

TABLE 1 (CONTINUOUS) riboflavin metabolizing nucleic acid amino acid numbering contig NT Start NT termination function SEQ ID NO SEQ ID NO 553554 RXN02246 VV 013043885371 Diaminohydroxyphosphisystemminoxidine deaminase (EC 3.5.4.26)/5-amino-

6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193)555 556 F RXAO2246 GRO0654 14299 15282 RIBG PROTEIN riboflavin-specific deaminase [EC：3.5.4.-]557 558 RXA02247 GR00654 15286 15918 RIBOFLAVIN SYNTHASE ALPHACHAIN (EC 2.5.1.9)559 560 RXN02248 VV0130 6021 7286 GTP CYCLOHYDROLASE II (EC 3.5.4.25)/3，4-DIHYDROXY-2-BUTANONE 4-

PHOSPHATE SYNTHASE561 562 F RXA02248 GR00654 15932 17197 RIBA PROTEIN-GTP cyclohydrolase II [EC：3.5.4.25]563 564 RXNO2249 VV0130 7301 7777 6，7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE (EC 2.5.1.9)565 566 F RXA02249 GR00654 17212 17688 RIBH PROTEIN-6，7-dimethyl-8-ribityllumazine synthase (dmrl synthase，lumazine

synthase，riboflavin synthase beta chain) [EC：2.5.1.9]567 568 RXA02250 GR00654 17778 18356 RIBX PROTEIN569 570 RXA01489 GR00423 3410 2388 RIBOFLAVIN KINASE (EC 2.7.1.26)/FMN ADENYLYLTRANSFERASE (EC

2.7.7.2)571 572 RXA02135 GR00639 2809 1736 NICOTINATE-NUCLEOTIDE-DIMETHYLBENZIMIDAZOLE

PHOSPHORIBOSYLTRANSFERASE (EC 2.4.2.21)573 574 RXA01489 GR00423 3410 2388 RIBOFLAVIN KINASE (EC 2.7.1.26)/FMN ADENYLYLTRANSFERASE (EC

2.7.7.2)575 576 RXN01712 VV0191 8993 8298 RIBOFLAVIN-SPECIFIC DEAMINASE (EC 3.5.4.-)577 578 F RXA01712 GR00484 2652 2152 RIBOFLAVIN-SPECIFIC DEAMINASE (EC 3.5.4.-)579 580 RXN02384 VV0213 1386 679 ALPHA-RIBAZOLE-5′-PHOSPHATE PHOSPHATASE (EC 3.1.3.-)581 582 RXN01560 VV0319 767 438 RIBOFLAVIN-SPECIFIC DEAMINASE (EC 3.5.4.-)583 584 RXN00667 VV0109 1363 360 DRAP DEAMINASE585 586 RXC01711 MEMBRANE SPANNING PROTEIN INVOLVED IN RIBOFLAVIN METABOLISM587 588 RXC02380 PROTEIN INVOLVED IN RIBOFLAVIN METABOLISM589 590 F RXA02380 GR00691 709 56 Predicted nucleotidyttransferases591 592 RXC02921 CYTOSOLIC PROTEIN INVOLVED IN METABOLISM OF RIBOFLAVIN AND

LIPIDS593 594 RXC01434 MEMBRANE SPANNING PROTEIN INVOLVED IN METABOLISM OF AROMATIC

AMINO ACIDS numbering contigs of AMINO ACIDS AND RiboFLAVIN vitamin B6 metabolic nucleic ACIDS NT initiation NT termination function SEQ ID NO 595596 RXA01807 GR 0050978667077 PYRIDOXINE KINASE (EC 2.7.1.35), pyridox/PYRIDOXINE KINASE

TABLE 1 (CONTINUO) NICKEL ACID, NICKEL AMIDE, NAD AND NADP nucleic acid amino acid numbering contig NT START TERMINATION FUNCTION SEQ ID NO SEQ ID NO 597598 RXN02754 VV 00842256423901 NICOTINATE PHOSPHORIBOLTRANSE (EC 2.4.2.11) 599600F RXA02405 GR 007017744 NICOTINATE PHOSPHORIBOLTRANSE (EC 2.4.2.11) 601602F RXA02754 GR 007663488 NICOTINATE PHOSPHORIBOLTRANSE (EC 2.4.2.11) 603604 RXA02112 GR 0063256006436 NICOTATE-NUCLEOTINATE PYROPHOSPLASE (CARBOXLATING) (EC 353535353535353525)

2.4.2.19) 605606 RXA02111 GR 0063243105593 QUINOLINATE SYNTHETASE ANAD biosynthetic nucleic acid amino acid numbering contig NT initiating NT termination function SEQ ID NO SEQ ID NO 607608 RXA01073 GR 0030012742104 NH (3) -DEPENDENT NAD (+) SYNTHETASE (EC 6.3.5.1) 609610 RXN02754 VW 008422564901 23nicotinate PHOSPHOSYLTRANFERASE (EC 2.4.2.11) pantothenic acid and coenzyme A (CoA) biosynthetic nucleic acid amino acid numbering contig NT initiating NT termination function SEQ ID NO SEQ ID NO 611612 GR 99 GR 006625210859 ASPARTATE 1-DECARBOXYLASE PRECURSOR (EC 4.1.1.11) 613614 RXA 28 00571GR PAPYTOATE-BETA ALANINE LIGASE (EC 4) 615616 RXN 019750194024023-METL-019483-METL-2-OYLINE SYNTHETASE ANAD-O3602250 (EC 36022489)

/DECARBOXYLASE (EC 4.1.1.44)617 618 F RXA01929 GR00555 2766 1960 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (EC 2.1.2.11)619 620 RXA01521 GR00424 25167 25964 PANTOATE-BETA-ALANINE LIGASE (EC 6.3.2.1)621 622 RXS01145 KETOL-ACID REDUCTOISOMERASE (EC 1.1.1.86)623 624 F RXA01145 GR00321 1075 1530 KETOL-ACID REDUCTOISOMERASE (EC 1.1.1.86)625 626 RXA02239 GR00654 5784 7049 DNA/PANTOTHENATE METABOLISM FLAVOPROTEIN627 628 RXA00581 GR00156 7572 8540 PANTOTHENATE KINASE (EC 2.7.1.33)629 630 RXS00838 2-DEHYDROPANTOATE 2-REDUCTASE (EC 1.1.1.169)631 632 RXC02238 PROTEIN INVOLVED IN METABOLISM OF S-ADENOSYLMETHIONINE，PURINES

AND PANOTHENATE BIOTIN metabolizing nucleic acid amino acid numbering contig NT initiating NT terminating function SEQ ID NO SEQ ID NO 633634 RXN03058 VV 002882728754 BIOTIN SYNTHESIS PROTEIN BIOC

TABLE 1 (continuation) nucleic acid AMINO acid numbering contig NT Start NT termination function SEQ ID NO 635636F RXA02903 GR 100401153212014 BIOTIN SYNTHESIS PROTEIN BIOC 637638 RXA00166 GR 00025504309 BIOTIN SYNTHESIS PROTEIN BIOC 639640 RXA00633 GR 0016635562288 ADENO SYLMETHIONINE-8-AMINO-7-OXONANANANANANANANE AMINOSTRANASE

(EC 2.6.1.62) 641642 RXA00632 GR 0016622811610 DEHIOBIOTIN SYNTHETAE (EC 6.3.3.3) 643644 RXA00295 GR 00047340408 BIOTIN SYNTHETAE (EC 2.8.1.6) 645646 RXA00223 GR 000322396722879 NIFS PROTEIN 647648 RXN00262 V01231668115608 NIFS PROTEIN 649650F RXA00262 GR 0004079897 NIFS PROTEIN 851652 RXN00435 V01121003711209 NIFS PROTEIN 653654F RXA 001003563249 FS NITEIN 655656F 02801 GR 007824384 NITEIN 65659 RXA 02A 020077658 SUZAGR 7242986 NIFS PROTEIN 659620 RXA 0202232007357451A 01569 NI GATEIN 355635569A 3556355631 OAD 15 OAE

OXOGLUTARATE DEHYDROGENASE COMPLEX (EC 2.3.1.61)669 670 RXS01260 LIPOAMIDE DEHYDROGENASE COMPONENT (E3) OF BRANCHED-CHAIN

ALPHA-KETO ACID DEHYDROGENASE COMPLEX (EC 1.8.1.4)671 672 RXS01261 LIPOAMIDE DEHYDROGENASE COMPONENT (E3) OF BRANCHED-CHAIN

ALPHA-KETO ACID DEHYDROGENASE COMPLEX (EC 1.8.1.4) folate biosynthesis nucleic ACID amino ACID numbering contig NT initiating NT terminating function SEQ ID NO 673674 RXA02717 GR 0075881174005, 10-METHYLEETHYLEETHYLERATE RECTASE (EC 567) 675676 RXN02027 VV 029650035-FORMYLRATE HYDROXYLATE CLO-LIGASE (EC 68) 677678F RXA02027 GR 1650065-FORMYLETHYLETHOLOGLE CLO-LIGASE (EC 6.3.3.2) 679680 RXA00106 000141747924 DIHYDROXYLECTOR RED CADE (EC 1.5.1.3) 0014 RXN 0188689788 FORMETHYLETHAT HYDROXYLEC 3535353535353535353535353535065-FORMATE (EC 00106) 006745) and 5-FORMATE HYDROXYLEC 3535353535353535353535353535353535353535353535353535355 (EC 11.5) A01YDROVATE 2 RXYLEC 35465) A353535353535353535353535353535353535353535353535355

METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE (EC 3.5.4.9)687 688 RXA01514 GR00424 20922 21509 GTP CYCLOHYDROLASE I (EC 3.5.4.16)689 690 RXA01516 GR00424 22360 22749 DIHYDRONEOPTERIN ALDOLASE (EC 4.1.2.25)

TABLE 1 (continuation) nucleic acid AMINO acid numbering contig NT initiating NT termination function SEQ ID NO SEQ ID NO 691692 RXA01515 GR 004242322364 DIHYDROPHONOTEXAE SYNTHASE (EC 2.5.1.15) 693694 RXA02024 GR 0061340264784 DIHYDROPHONOTEXAE SYNTHASE (EC 2.5.1.15) 695696 RXA00106 GR 000141691747924 DIHYDROPHONOTEXATE REDUCTASE (EC 1.5.1.3) 697698 RXA00989 GR 00229031371 LYLPOLYTLYPHYLLOXYTETRAMATE SYNTHASE (EC 6.3.2.17) 699700 RXA01517 GR 00427232242282-AMINO-4-HYDROXY-6-HYDROXYYME YLMETH YLHYDROXYPRODINE SYNTHASE

PYROPHOSPHOKINASE (EC 2.7.6.3)701 702 RXA00579 GR00156 5946 4087 PARA-AMINOBENZOATE SYNTHASE COMPONENT I (EC 4.1.3.-)703 704 RXA00958 GR00264 1130 1753 PARA-AMINOBENZOATE SYNTHASE GLUTAMINE AMIDDTRANSFERASE

COMPONENT II (EC 4.1.3.-)/ANTHRANILATE SYNTHASE COMPONENT II (EC

4.1.3.27)705 706 RXA02790 GR00777 5806 6948 4-AMINO-4-DEOXYCHORISMATE LYASE (EC 4.-.-.-)707 708 RXA00106 GR00014 17469 17924 DIHYDROFOLATE REDUCTASE (EC 1.5.1.3)709 710 RXN02198 VV0302 9228 11726 5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE METHYLTRANSFERASE

(EC 2.1.1.13)711 712 F RXN02198 GR00646 2483 6 5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE METHYLTRANSFERASE

(EC 21.1.13)713 714 RXN02085 VV0126 8483 10717 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE-HOMOCYSTEINE

METHYLTRANSFERASE715 716 F RXA02085 GR00629 3496 5295 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE-HOMOCYSTEINE

METHYLTRANSFERASE (EC 2.1.1.14)717 718 F RXA02086 GR00629 5252 5731 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE-HOMOCYSTEINE

METHYLTRANSFERASE (EC 2.1.1.14)719 720 RXN02648 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE-HOMOCYSTEINE

METHYLTRANSFERASE (EC 2.1.1.14)721 722 F RXA02648 GR00751 5254 4730 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE-HOMOCYSTEINE

METHYLTRANSFERASE (EC 2.1.1.14)723 724 F RXA02658 GR00752 14764 15447 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE-HOMOCYSTEINE

METHYLTRANSFERASE (EC 2.1.1.14)725 726 RXS02197 5-METHYLTETRNHYDROFOLATE-HOMOCYSTEINE METHYLTRANSFERASE

(EC 2.1.1.13) 727728 RXC00988 PROTECTIN INVOLATED IN FOR METABOLISM 729730 RXC01518 MEMBRANE SPANNING PROTEIN INVOLATED IN METLATE METABOLISM 731732 RXC01942 ATP-BINDING PROTEIN INVOLATED IN METABOLITE MOLYLATE MOLYPTER amino acid numbering juxtaposition to the group NT initiating and terminating functions SEQ ID NO 733734 RXN02802 VVC 01121736916299 MOBDOPTERIN BIYNTHENS MOLYPTIN 735736F 02802 RYPTO 7474 MOLYBDPHOSPITRIN BIOPTERIN BIOSTHESIS EB 73735 RXLYBDPHOSPRIN 0046203338 GR 001GR 796 MOLYBDESIN 01121751-PHOSPORTHESIN 357346, MOPHOSPIDTYPE PHON 2177336004735639 MOPHON, MOPHOSPITRIN-PHOSPITRIN-MAGNOPTER-MAGNET-PHOSPITRIN-MAGNOPTER 357478-MAGNET-MAGNOPTER-MAGNET-MAG-MAGNET-MAG-MAGNET-MAG

TABLE 1 (continuation) nucleic acid amino acid numbering contig NT initiating NT termination function SEQ ID NO SEQ ID NO 749750 RXA00440 GR 00104196654 MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN CB 751752 RXN00441 VV 01121994218779 MOLYBDOPTERIN CO-FACTOR SYNTHESIS PROTEIN 753754F RXA00441 GR 001052793 MOLYBDOPTERIN CO-FACTOR SYNTHESIS PROTEIN 755756 RXN 020855-METHYLTROHYDROPHOSPRINE

METHYLTRANSFERASE (EC 2.1.1.14)757 758 F RXA02085 GR00629 3496 5295 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE

METHYLTRANSFERASE (EC 2.1.1.14)759 760 F RXA02086 GR00629 5252 5731 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE

METHYLTRANSFERASE (EC 2.1.1.14)761 762 RXN02648 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE

METHYLTRANSFERASE (EC 2.1.1.14)763 764 F RXA02648 GR00751 5254 4730 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE

METHYLTRANSFERASE (EC 2.1.1.14)765 766 F RXA02658 GR00752 14764 15447 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE

METHYLTRANSFERASE (EC 2.1.1.14)767768 RXA01516 GR00424 22360 22749 DIHYDRONEOPTERIN ALDOLASE (EC 4.1.2.25)769 770 RXA01515 GR00424 21513 22364 DIHYDROPTEROATE SYNTHASE (EC 2.5.1.15)771 772 RXA02024 GR00613 4026 4784 DIHYDROPTEROATE SYNTHASE (EC 2.5.1.15)773 774 RXA01719 GR00488 1264 704 MOLYBDOPTERIN-GUANINE DINUCLEOTIDE BIOSYNTHESIS PROTEIN A775 776 RXA01720 GR00488 2476 1268 MOLYBOOPTERIN BIOSYNTHESIS MOEA PROTEIN777 778 RXS03223 MOLYBOOPTERIN BIOSYNTHESIS MOEA PROTEIN779 780 F RXA01970 GR00568 2 1207 MOLYBDOPTERIN BIOSYNTHESIS MOEA PROTEIN781 782 RXA02629 GR00748 1274 690 MOLYBDOPTERIN BIOSYNTHESIS CNX1 PROTEIN783 784 RXA02318 GR00665 9684 9962 (D90909) pterin-4a-carbinolamine dehydratase [Synechocystis sp.]785 786 RXA01517 GR00424 22752 23228 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE

PYROPHOSPHOKINASE (EC 2.7.6.3)787 788 RXN01304 VV0148 4449 4934 MOLYBDOPTERIN BIOSYNTHESIS MDG PROTEIN789 790 RXS02556FLAVOREMOPROTEIN/DIHYDROPTERIDINE REDUCTASE (EC 1.6.99.7)791 792 RXS02560 OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE (EC 1.-.-.-)/

Dihydropteridipine REDUCTASE (EC1.6.99.7) vitamin B₁₂Porphyrin and heme metabolizing nucleic acid amino acid numbering contig NT Start NT termination function SEQ ID NO 793794 RXA00382 GR 0008227521451 GLUTAMATE-1-SEMIALDEHYDE 2, 1-AMINOMETASE (EC ID NO 793794 RXA00382 GR 0008227521451 GLUTAMATE-1-SEMIALDEHYDE)5.4.3.8)795 796 RXA00156 GR00023 10509 9400 FERROCHELATASE (EC 4.99.1.1)797 798 RXA00624 GR00163 7910 8596 FERROCHELATASE (EC 4.99.1.1)799 800 RXA00306 GR00051 2206 1274 HEMK PROTEIN801 802 RXA00884 GR00242 10137 11276 OXYGEN-INDEPENDENT COPROPORPHYRINOGEN III OXIDASE (EC 1.-.-.-)803 804 RXN02503 VV0007 22456 22854 PORPHOBILINOGEN DEAMINASE (EC 4.3.1.8)805 806 F RXA02503 GR00720 16906 17340 PORPHOBILINOGEN DEAMINASE (EC 4.3.1.8)807 808 RXA00377 GR00081 1427 306 UROPORPHYRINOGEN DECARBOXYLASE (EC 4.1.1.37)809 810 RXN02504 VV0007 22805 23362 PORPHOBILINOGEN DEAMINASE (EC 4.3.1.8)811 812 F RXA02504 GR00720 17379 17816 PORPHOBILINOGEN DEAMINASE (EC 4.3.1.8)

TABLE 1 (continuation) nucleic acid amino acid numbering contig NT initiating NT termination function SEQ ID NO SEQ ID NO 813814 RXN01162 VV 00881849524 PRECORRIN-6Y METHYLASE (EC 2.1.1.-) 815816F RXA01162 GR 0033012484 PRECORRIN-6Y METHYLASE (EC 2.1.1.-) 817818 RXA01692 GR 004748749 UROPORPHYRIN-III C-METHYLTRANSFERASE (EC 2.1.1.107) 819820 RXN 71 VV 022645973 UROPPHORPHYRIN-III C-METHYLTRANSFERASE (EC 2.1.1.107)

UROPORPHYRINOGEN-III SYNTHASE (EC 4.2.1.75)821 822 F RXA00371 GR00078 929 6 UROPORPHYRIN-III C-METHYLTRANSFERASE (EC 2.1.1.107)/

UROPORPHYRINOGEN-III SYNTHASE (EC 4.2.1.75)823 824 F RXA00374 GR00079 1102 371 UROPORPHYRIN-III C-METHYLTRANSFERASE (EC 2.1.1.107)/

UROPORPHYRINOGEN-III SYNTHASE (EC 4.2.1.75)825 826 RXN00383 VV0223 4206 2863 PROTOPORPHYRINOGEN OXIDASE (EC 1.3.3.4)827 828 F RXA00376 GR00081 287 6 PROTOPORPHYRINOGEN OXIDASE (EC 1.3.3.4)829 830 F RXA00383 GR00082 3876 2863 PROTOPORPHYRINOGEN OXIDASE (EC 1.3.3.4)831 832 RXA01253 GR00365 25361787 COBYRIC ACID SYNTHASE833 834 RXA02134 GR00639 1721 801 COBALAMIN (5′-PHOSPHATE) SYNTHASE835 836 RXA02135 GR00639 2809 1736 NICOTINATE-NUCLEOTIDE-DIMETHYLBENZIMIDAZOLE

PHOSPHORIBOSYLTRANFERASE (EC 2.4.2.21) 837838 RXA02136 GR 0063933622841 COBINAMINIDE KINASE/COBINAMIDE PHOSPHOTE GUANYLLYLTRANFERASE 8340 RXN03114 VV 00881552 COBG PROTEIN (EC 1.-) 841842 RXN01810 VVA 00821739663 HEMIN-BINDING PERPLASTIN HMUT PRECURSOR 843844 RXSS 03205 HEMK PROTEIN 5846F 00306 HEMK PROTEIN 847848C 01715 CYRXOLIC PROIN PHYLRIN METHYBRIC PRECURSOR nucleic ACID amino ACID numbering abutting the group NT start NT GR 20331 GR 00031 GR 0420 RXNO 048L-GUNOLADASE 0043535353535353531-00027 GR 3692 (GUPHOSPHORIC 35567-GCYTE 357223,9231-GCE 355631-GCYTE 357223,359-GCO 3515-GCE 355631-GCE 357223,9223, 5-DIKETO-D-GLUCONIC ACID REDUCTASE (EC 1.1.1.-) 861862 RXS00389 oxogluterate semialdehyde dehydrogenase (EC 1.2.1.-) 863864 RXS00419 ACETOACETYL-COA REDUCTASE (EC 1.1.1.36) 865866 RXC00416 MEMBRANE NNSPANING PROTEIN INVOLVELVED IN METOLISM OF VITAC PRECURSORS 867868 RXC02206 OXIDORREDUCTASE INVOLVELVED IN METOLOF VITAMIN C PREVORS VITAMIN K2 nucleic ACID amino ACID numbering contiguously to the initial NT termination function SEQ ID NO SEQ ID NO 9870 RXSO 3074S-ADENOSYLMETHIONE: 2-DEMETHYLMENAQINONE

METHYLTRANSFERASE (EC 2.1 .-.-)

Table 1 (continuous) nucleic acid amino acid numbering contigs NT start NT termination function SEQ ID NO 871872F RXA02906 GR 100441142645S-adonosylmemonine: 2-DEMETHYLMENAQINONE

METHYLTRANSFERASE (EC 2.1.-.-)873 874 RXA02315 GR00665 8011 6383 2-SUCCINYL-6-HYDROXY-2，4-CYCLOHEXADIENE-1-CARBOXYLATE

SYNTHESE/2-OXOGLUTATERATE DECARBOXYLASE (EC 4.1.1.71) 875876 RXA02319 GR 00665997710933 NAPHTHATE SYNTHESE (EC 4.1.3.36) 877878 RXS 003931, 4-DIHYDROXY-2-NAPHTHOATE OCTAPRENYLDFRASE (EC 2.5. -) 879880F RXA00393 GR 000403049111, 4-DIHYDROXY-2-HTHAATE OCTANYLTRYPERFERASE RASE (EC 2.5. -) 881882A 00391 0008612750 GR-SUCCINYLBENANOIC ACID-LIGASE (EC 6.2.1.26) 883884 RXS 02908O-SUCCINYLNOBENANOZOACID-COA LIGASE (EC 6.2.1.26) 3558355838-355835897-355639 DEMETHYNOQUE QUANE, No. (EC 2.5. -) 355635583556355639-355639A BioNOQUENTIANOQUENTIANOLYNOTUBE, No. 2-35583558355641897-355631.

(EC 2.1.1.-) 893894 RXS00998 COMA OPERON PROTEIN 2 purine, pyrimidine and other nucleotide purine, pyrimidine biosynthetic pathway Regulation purine metabolism purine biosynthesis nucleic acid amino acid numbering contig NT Start NT termination function SEQ ID NO SEQ ID NO 895896 RXA01215 GR 003521187213 RIBOSE-PHOSPHATE PYROPHOSPHONASE, PRPP syntthetase (EC 2.7.6.1) 897898 RXN00558 VV 010382359581 AMOPHOSPHORIBOSYLTRANSASE (EC 2.4.2.14) 899900F RXA00558 GR 0014861AMOPHOSPHORIBORASE (EC 2.4.2.14) 90RXN 00626 01351160362 PHHORIBOSYLAMINE-GLYCINE LIGASE (EC 6.3.4.13) 903904F 01001659 GR 001659 PHHOSPHOSAR PHOSPHORIBO ASE-353535353535048 PHHORIBO SYRIBO-3536353655 (EC 363536353635363536353655) SYRIBO 35353535353635363535363535353635363536353655A 363535353635363536353635353536353635363536353635363536353655A 3635363536353655A 363536353635363536353635363536353655A

PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE (EC 6.3.3.1)/

PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE (EC 2.1.2.2)909 910 RXA01442 GR00418 10277 9054 PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE 2 (EC 2.1.2.-)

TABLE 1 (continuation) nucleic acid amino acid numbering contig NT initiating NT termination function SEQ ID NO SEQ ID NO 911912 RXN00537 VV 010333515636 PHOSPHORIBOSYLFORMYCINAMINIDINE SYNTHESE (EC 6.3.5.3) 913914F RXA02805 GR 0078654638 PHOSPHORIBOSYLFYLCINAMINIDINE SYNTHESE (EC 6.3.5.3) 915916F RXA00537 GR 0013823697 PHOSPHORIBOSYLFORMYCINAMINIDINE SYNTHESE (EC 6.3.5.3) 917918F RXA00561 GR 001280 PHOSPHORIBOSYLFORMYLGLYCINAMINIDINE SYNTHESE (EC 5639) 919920A 00541A 0019239226937 PHOSPHORIBOSYRIBOMYCINOMINIDINE SYNTHESE (EC 6.3.5.3) 36001639 PHYLOXYAMYCINOMYCINOMYCINAMINE SYNTHESE 3049-939 SYPHOSPHORIBORIBORIBORIC

(EC 6.3.2.6)923 924 RXN00770 VV0103 9614 10783 PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE (EC 6.3.3.1)925 926 F RXA00557 GR00147 15 818 PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE (EC 6.3.3.1)927 928 F RXA00770 GR00204 7809 7495 PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE (EC 6.3.3.1)929 930 RXN02345 VV0078 4788 5984 PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE ATPASE SUBUNIT (EC

4.1.1.21)931 932 F RXA02345 GR00676 1534 725 PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE ATPASE SUBUNIT (EC

4.1.1.21)933 934 RXN02350 VV0078 8369 8863 PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE CATALYTIC SUBUNIT

(EC 4.1.1.21)935 936 F RXA02346 GR00677 127 5 PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE CATALYTIC SUBUNIT

(EC 4.1.1.21)937 938 F RXA02350 GR00678 1120 911 PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE CATALYTIC SUBUNIT

(EC 4.1.1.21)939 940 RXA01087 GR00304 498 1373 PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE (EC 4.1.1.21)941 942 RXA00619 GR00163 793 2220 ADENYLOSUCCINATE LYASE (EC 4.3.2.2)943 944 RXA02622 GR00746 4274 2715 PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXAMIDE FORMYLTRANSFERASE

(EC 2.1.2.3)/IMP CYCLOHYDROLASE (EC 3.5.4.10) GMP, GDP, AMP and ADP synthesis starting from the nucleic acid amino acid numbering of INOSINE-5 '-MONOPHOSPHATE (IMP) adjacent group NT start NT termination functions SEQ ID NO 945946 RXN00488 VW 00861906683 INOSINE-5' -MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205) F RXA00492 GR 0012212212211644 INOSINE-5 '-MONOPHOSPHATE DEHYDROGESE (EC 1.1.1.205) 949950F RXA 001211534 OSINE-5' -MONOPHOSPHATE DEHYDROGESE (EC 1.1.1.205) 951952 RXA024 GR 15192GR 74000743574357441599 GR 36415935 GR 3655 FYDPHONE 3655 GYP 001355935 GYP 355935 GYP A355947 GR 3655 GYP A35004355947 GR 3641355947 GYP 355947 GR 3655 GYP A355947 GR 3641355947A 355947A 368646 (EC 365947) A006415947A 00641598) A35598A KINASE (EC 2.7.4.6)

Table 1 (continuation) GMP/AMP degrading active nucleic acid amino acid numbering contigs NT start NT termination function SEQ ID NO 967968 RXA00489 GR 001216541775 GMP redact (EC 1.6.6.8) 969970 RXN02281 VV 015218933323 AMP nucletisidase (EC 3.2.2.4) 971972F RXA02281 GR 00659110134 AMP nucletisidase (EC 3.2.2.4) pyrimidine metabolizing pyrimidine de novo biosynthesis: nucleic acid amino acid numbering contig NT initiating NT terminating function SEQ ID NO 973977397739972900 carbmoyl-phospate SYNTHASE SMALL CHAIN (EC 6.3.5.5) 975976 RXA00145 GR 00022588193 ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CHAIN (EC 2.1.3.2) 977978 RXA00146 GR 0002282499589589 dihydroxotase (EC 3.5.2.3) 979980 RXA02208 GR 0064703 dihydroxotate E DEHYDROGENASE (EC 979980) 979980 RXA 660 GR 004625912 orvate phnorbomyl fluoride FERASE (EC 979980) 979980 GR 00436363630363036363600136413646 GR 3636360013680 364736473680 36360013680 f360136363636363636363646 rxeq 3647364736473647364736473676 (rxf360013680) 360136363636364136363636413680 rxyl 3636363636363636363641364136413641364136413655 CARBAMOYL-PHOSPHATE SYNTHASE LARGE CHAIN (EC 6.3.5.5) 10031004 RXN00450 VV 01123449134814 CYTOSONE DEAMENSE (EC 3.5.4.1) 10051006F RXA00450 GR 001103225 CYTOSONE DEAMENSE (EC 3.5.4.1) 10071008 RXN02272 VV 00201556616810 CYINE DEAMENSE (EC 3.5.4.1) 10091010F RXA02272 GR 0065566917962 (EC 3.5.4.21) 10111012 RXN03004 VV 023718641 DEOXYTIDINE TRIPHOSHATE DEAMENSE (EC 3.5.4.13) 10131014N 03137 RXN 01299680957 THYMIDYLATE SYNTHASE (EC 2.1.1.45) 10151016 RXN031 681 032 85080 UR 080 SYPHOSPHASE DASE DEFLEXPHOSPHATE DEX 3510825 (EC 2.1.31) RAFER 703568) BEL 3544

Table 1 (continuous) purine and pyrimidine bases, nucleotide and nucleoside salvage, interconversion, reduction and degradation: purine: nucleic acid amino acid numbering contig NT initiating NT termination function SEQ ID NO 10191020 RXA02771 GR 0077213291883 ADENINE PHOSPHORIBOSYLTRANFERASE (EC 2.4.2.7) 10211022 RXA01512 GR 0042417633132 HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSE (EC 2.4.2.8) 10231024 RXA02031 GR 0061838203347 NTXAHINE-ANGULANE PHOSPHORIBOLTRANFERASE (EC 2.4.2.22) 10251026 RXA00981 GR 0027633887 GTP PHOSPHOPHOSPHONASE (EC 2.7.6.5) 10271028 RXA 2772 VV 017120451011 GUANOSINE-3 ', 5 ' -BIS DIPHOSPHOTE) 3 ' -PYOSPHOSPHOSE (EC 2.7.6.5)

3.1.7.2)1029 1030 F RXA02772 GR00772 1962 2741 GUANOSINE-3′，5′-BIS(DIPHOSPHATE) 3′-PYROPHOSPHOHYDROLASE (EC

3.1.7.2)1031 1032 F RXA02773 GR00772 2741 2902 GUANOSINE-3′，5′-BIS(DIPHOSPHATE) 3′-PYROPHOSPHOHYDROLASE (EC

3.1.7.2)1033 1034 RXA01835 GR00517 3147 3677 GUANOSINE-3′，5′-BIS(DIPHOSPHATE) 3′-PYROPHOSPHOHYDROLASE (EC

3.1.7.2)1035 1036 RXA01483 GR00422 19511 18240 DEOXYGUANOSINETRIPHOSPHATE TRIPHOSPHOHYDROLASE (EC 3.1.5.1)1037 1038 RXN01027 VV0143 5761 6768 DIADENOSINE 5′，5_-P1，P4-TETRAPHOSPHATE HYDROLASE (EC 3.6.1.17)1039 1040 F RXA01024 GR00293 661 5 DIADENOSINE 5′，5_-P1，P4-TETRAPHOSPHATE HYDROLASE (EC 3.6.1.17)1041 1042 F RXA01027 GR00294 2580 2347 DIADENOSINE 5′，5_-P1，P4-TETRAPHOSPHATE HYDROLASE (EC 3.6.1.17)1043 1044 RXA01528 GR00425 5653 5126 DIADENOSINE 5′，5_-P1，P4-TETRAPHOSPHATE HYDROLASE (EC 3.6.1.17)1045 1046 RXA00072 GRO0012 446 6 PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE (EC 1.8.99.4)1047 1048 RXA01878 GR00537 1239 2117 DIMETHYLADENOSINE TRANSFERASE (EC 2.1.1.-)1049 1050 RXN02281 VV0152 1893 3323 AMP NUCLEOSIDASE (EC 3.2.2.4)1051 1052 F RXA02281 GR00659 1101 34 AMP NUCLEOSIDASE (EC 3.2.2.4)1053 1054 RXN01240 VV0090 30442 29420 GTP PYROPHOSPHOKINASE (EC 2.7.6.5)1055 1056 RXN02008VV0171 1138 5 GUANOSINE-3′，S′-BIS(DIPHOSPHATE) 3′-PYROPHOSPHOHYDROLASE (EC

3.1.7.2) pyrimidine and purine metabolism: nucleic acid amino acid numbering the contig NT initiating NT terminating function SEQ ID NO 10571058 RXN01940 VV 0120102689333 INOSINE-URIDINE PREFERRING nuclearoside hydrate (EC 3.2.2.1) 10591060F RXA01940 GR 005573573573 573 inhosine-URIDINE PREFERRING nuclearing nuclear 02559 GR 00731186320 INOSINE-URIDINE PREFERRING nutricine hydrate (EC 3.2.2.1) 10611062 RXA02559 GR 0073154186320 inkernel-ursine-urseine nutri 024 00431 GR 360049 GR 00431 GR 3601035982 riine-01035003350104151 sang 323501035 gra 01051 sang 3235982 sang-sanguie-323501032 sang 323501051 sang 01035 sang 3501032 sang 3501032 and sang 3 sang 3 sang 3 sang 3 n sang 3 sang 48 sang 3 sang 3 sang 3 sang 3 sang 3 sang 3 sang 3 sang.

TABLE 1 (continuation) nucleic acid amino acid numbering contig NT initiating NT terminating function SEQ ID NO 10831084 RXA01678 GR 00467716276892 ', 3' -CYCLIC-NUCLEOTIDE 2 '-PHOSPHODIESSION (EC 3.1.4.16) 10851086 RXA01679 GR 004672989642', 3 '-CYCLIC-NUCLEOTIDE 2' -PHOSPHODIESSION (EC 3.1.4.16) 10871088 RXN 88 V013984789 INONE-URIDINE PRERRING NUCLEOTOSIDE HYDROLOSE (EC 3.2.2.1) 10891090 RXC00540 CYCLOOLIC PROTEIN PULVINE METHYLENE 10910992 RXYPROLINE 10926C 00560 PROTEIN PHOSPHOLINNEE MULTIPLE ISM ABLINE METE OPROT METE 10994 RYPIN 10994C 10997 NEPHOSPHOL PROTEIN PHOSPHOL PHOSPHOLINE PRONEE 1098, PHOSPHOLINE MULTIPLE BEN PHOSPHORUNE MULTIPLE BEN PHOSPHOLINE PROLINE MULTIPLE BENE MULTIPLE BEN 10994, PHOSPHOLINE MULTIPLE INS MULTIPLE INS MULTIPLE INS MULTIPLE INS MULTIPLE INS

AND PANTOTHENATE1103 1104 RXC01946ABC TRANSPORTER ATP-BINDING PROTEIN INVOLVED IN PURINE

METABOLISM pyrimidine: nucleic acid amino acid numbering contig NT initiating NT termination function SEQ ID NO 11051106 RXN03171 VW 03285681080 URACIL phosphori sylvestige (EC 2.4.2.9) 11071108F RXA02857 GR 100035701082 URACIL phosphori sylvestige (EC 2.4.2.9) 11091110 RXN00450 VW 23423449134814 cytosane DENASE (EC 3.5.4.1) 11111112F RXA00450 GR 001225 cyodine DENASE NASE (EC 3.5.4.1) 11131114A 00465 RXA rxcyeine DENASE NASE 35533501041355926 GR 4151 GR 41355926 GR 4151 WYTE YPE 355926A 3552, 3501051A 3501092A 01055 RXPHOSPIDE DE NASE 3501051A 3501051 NASE 35599A 3501051 WYTE NASSUE SYSTEP 92A 353501051 WYSE A3535353535598A 3501051 WYTE GCR 3501051 GR 4151 WYTE A3552A 354151 WYTE A3552A 35598 GR 4151 WYTE A3552A 35598 GR 4151 WYS 3552A 35598A 3501051 WYS pG51A 3552A 1A 3551 WYS pGE A3569A 35704151 WYS 3552A 35598A 3552A 1A 35598A 1A 3552A 35598A 1 WYSA 3552A 1 WYSA 1A 1 WYTE WO 2A 1A 35598A 3552A 1 WYSA WYSYL A1A WYTE A3552A 1.

ADENOSYLHOMOCYSTEINE1135 1136 RXC01709 CYTOSOLIC PROTEIN INVOLVED IN PYRIMIDINE METABOLISM1137 1138 RXC02207 EXPORTED PROTEIN INVOLVED IN PYRIMIDINE METABOLISM

TABLE 1 (CONTINUOUS) SUGARCHALOSACCHARIDE AMINO ACID NUMBER PROPERTIES NT INITIATING NT TERMINATION FUNCTIONS SEQ ID NO 11391140 RXA00347 GR 000652461013 TREHALOSE-PHOSPHATASE (EC 3.1.3.12)1141 1142 RXN01239 VV0090 32921 30489 maltooligosyltrehalose synthase1143 1144 F RXA01239 GR00358 5147 7579 maltooligosyltrehalose synthase1145 1146 RXA02645 GR00751 714 2543 maltooligosyltrehalose trehalohydrolase1147 1148 RXN02355 VV0051 735 4 TREHALOSE/MALTOSE BINDING PROTEIN1149 1150 RXN02909 VV0135 38532 39017 Hypothetical Trehalose-Binding Protein1151 1152 RXS00349 Hypothetical Trehalose Transport Protein1153 1154 RXS03183 TREHALOSE/MALTOSE BINDING PROTEIN1155 1156 RXC00874 TRANSMEBRANE PROTEIN INVOLVED IN TREHALOSE METABOLISM

TABLE 2 excluded genes
	GenBankTM Retrieval number	Name of Gene	Gene function	Literature reference
A09073					ppg	Phosphoenol pyruvate carboxylase	Bachmann，B.et al.“DNA fragment coding for phosphoenolpyruvat corboxylase，recombinant DNA carrying said fragment，strains carrying the recombinant DNA and method for producing L-aminino acids using said strains，”Patent：EP 0358940-A 3 03/21/90
	A45579， A45581， A45583， A45585 A45587		Threonine dehydratase	Moeckel，B.et al.“Production of L-isoleucine by means of recombinant micro-organisms with deregulated threonine dehydratase，”Patent：WO 95 19442-A 5 07/20/95
AB003132					murC；ftsQ；ftsZ		Kobayashi，M.et al.“Cloning，sequencing，and characterization of the ftsZ gene from coryneform baceria，”Biochem.Biophys.Res.Commun.， 236(2)：383-388(1997)
	AB015023	murC；ftsQ		Wachi，M.et al.“A murC gene from Coryneform bacteria，”Appl. Microbiol. Biotechnol.，51(2)：223-228(1999)
AB018530					dtsR		Kimura，E.et al.“Molecular cloning of a novel gene，dtsR，which rescues the detergent sensitivity of a mutant derived from Brevibacterium lactofermentum，”Biosci.Biotechnol. Biochem.，60(10)：1565-1570(1996)
	AB018531	dtsR1：dtsR2
AB020624					murl	D-glutamate racemase
	AB023377	tkt	transketolase
AB024708					gltB；gltD	Glutamine 2-oxoglutarate aminotransferase large and small subunits
	AB025424	acn	aconitase
AB027714					rep	Replication protein
	AB027715	rep；aad	Replication protein；aminoglycoside adenyltransferase
AF005242					argC	N-acetylglutamate-5-semialdehyde dehydrogenase
	AF005635	glnA	Glutamine synthetase
AF030405					hisF	cyclase
	AF030520	argG	Argininosuccinate synthetase
AF031518					argF	Ornithine carbamolytransferase
	AF036932	aroD	3-dehydroquinate dehydratase
AF038548					pyc	Pyruvate carboxylase

Table 2 (continuation)
	AF038651	dciAE；apt；rel	Dipeptide-binding protein；adenine phosphoribosyltransferase；GTP pyrophosphokinase	Wehmeier，L.et al.“The role of the Corynebacterium glutamicum rel gene in (p)ppGpp metabolism，”Microbiology，144：1853-1862(1998)
AF041436					argR	Arginine repressor
	AF045998	impA	Inositol monophosphate phosphatase
AF048764					argH	Argininosuccinate lyase
	AF049897	argC；argJ；argB； argD；argF；argR； argG；argH	N-acetylglutamylphosphate reductase； ornithine acetyltransferase；N- acetylglutamate kinase；acetylornithine transminase：ornithine caroamoyltransterase；arginine repressor； argininosuccinate synthase； argininosuccinate lyase
AF050109					inhA	Enoyl-acyl carrier protein reductase
	AF050166	hisG	ATP phosphoribosyltransferase
AF051846					hisA	Phosphoribosylformimino-5-amino-1- phosphoribosyl-4-imidazolecarboxamide isomerase
	AF052652	metA	Homoserine O-acetyltransferase	Park，S.et al.“Isolation and analysis of metA，a methionine biosynthetic gene encoding homoserine acetyltransferase in Corynebacterium glutamicum，”Mol. Cells.，8(3)：286-294(1998)
AF053071					aroB	Dehydroquinate synthetase
	AF060558	hisH	Glutamine amidotransferase
AF086704					hisE	Phosphoribosyl-ATP- pyrophosphohydrolase
	AF114233	aroA	5-enolpyruvylshikimate 3-phosphate synthase
AF116184					panD	L-aspartate-alpha-decarboxylase precursor	Dusch，N.et al.“Expression of the Corynebacteriunr glutamicum pan D gene encoding L-aspartate-alpha-decarboxylase leads to pantothenate overproduction in Escherichia coli，”Appl.Environ.Microbiol.，65(4)1530- 1539(1999)
	AF124518	aroD；aroE	3-dehydroquinase：shikimate dehydrogenase
AF124600					aroC；aroK；aroB； pepQ	Chorismate synthase；shikimate kinase；3- dehydroquinate synthase；putative cytoplasmic peptidase
	AF145897	inhA
AF145898					inhA

Table 2 (continuation)
	AJ001436	ectP	Transport of ectoine，glycine betaine， proline	Peter，H.et al.“Corynebacterium glutamicum is equipped with four secondary carriers for compatible solutes：Identification，sequencing，and characterization of the proline/ectoine uptake system，ProP，and the ectoine/proline/glycine betaine carrier，EctP，”J.Bacteriol.，180(22)：6005-6012(1998)
AJ004934					dapD	Tetrahydrodipicolinate succinylase (incompletei)	Wehrmann，A.et al.“Different modes of diaminopimelate synthesis and their role in cell wall integrity：A study with Corynebacterium glutamicum，”J. Bacteriol.，180(12)：3159-3165(1998)
	AJ007732	ppc；secG；amt；ocd； soxA	Phosphoenolpyruvate-carboxylase；？；high affinity ammonium uptake protein；putative ornithine-cyclodecarboxylase；sarcosine oxidase
AJ010319					ftsY，glnB，glnD；srp； amtP	Involved in cell division；Pll protein； uridylyltransferase(uridylyl-removing enzrnye)；signal recognition particle；low affinity ammonium uptake protein	Jakoby，M.et al.“Nitrogen regulation in Corynebacterium glutamicum； Isolation of genes involved in biochemical characterization of corresponding proteins，”FEMS Microbiol，173(2)：303-310(1999)
	AJ132968	cat	Chloramphenicol aceteyl transferase
AJ224946					mqo	L-malate：quinone oxidoreductase	Molenaar，D.et al.“Biochemical and genetic characterization of the membrane-associated malate dehydrogenase(acceptor)from Corynebacterium glutamicum，”Eur.J.Biochem.，254(2)：395-403(1998)
	AJ238250	ndh	NADH dehydrogenase
AJ238703					porA	Porin	Lichtinger，T.et al.“Biochemical and biophysical characterization of the cell wall porin of Corynebacterium glutamicum：The channel is formed by a low molecular mass polypeptide，”Biochemistry，37(43)：15024-15032(1998)
	D17429		Transposable element IS31831	Vertes et al.“Isolation and characterization of IS31831，a transposable element from Corynebacterium glutamicum，”Mol.Microbiol.，11(4)：739-746(1994)
D84102					odhA	2-oxoglutarate dehydrogenase	Usuda，Y.et al.“Molecular cloning of the Corynebacterium glutamicum (Brevibacterium lactofermentum AJ12036)odhA gene encoding a novel type of 2-oxoglutarate dehydrogenase，”Microbiology，142：3347-3354(1996)
	E01358	hdh：hk	Homoserine dehydrogenase；homoserine kinase	Katsumata，R.et al.“Production of L-thereonine and L-isoleucine，”Patent：JP 1987232392-A 1 10/12/87
E01359						Upstream of the start codon of homoserine kinase gene	Katsumata，R.et al.“Production of L-thereonine and L-isoleucine，”Patent：JP 1987232392-A 2 10/12/87
	E01375		Tryptophan operon
E01376					trpL；trpE	Leader peptide；anthranilate synthase	Matsui，K et al.“Tryptophan operon，peptide and protein coded thereby， utilization o trryptophan operon gene expression and production of tryptophan，”Patent：JP 1987244382-A 1 10/24/87

TABLE 2(continuation)
	E01377		Promoter and operator regioins of tryptophan operon	Matsui，K.et al.“Tryptophan operon，peptide and protein coded thereby， utilization of tryptophan operon gene expressior and production of tryptophan，”Patent：JP 1987244382-A 1 10/24/87
E03937						Biotin-synthase	Hatakeyama，K.et al.“DNA fagment containing gene capable of coding biotin synthetase and its utilization，”Patent：JP 1992278088-A 1 10/02/92
	E04040		Diamino pelargonic acid aminotransferase	Kohama，K.et al.“Gene coding diaminopelargonic acid aminotransferase and desthiobiotin synthetase and its utilization，”Patent：JP 1992330284-A 1 11/18/92
E04041						Desthiobiotinsyntherase	Kohama，K.et al.“Gene coding diaminopelargonic acid aminotransferase and desthiobiotin synthetase and its utilization，”Patent：JP 1992330284-A 1 11/18/92
	E04307		Flavum aspartase	Kurusu，Y.et al.“Gene DNA coding aspartase and utitization thereof，”Patent： JP 1993030977-A 1 02/09/93
E04376						Isocitric acid lyase	Katsumata，R.et al.“Gene manifestation controlling DNA，”Patent：JP 1993056782-A 3 03/09/93
	E04377		Isocitric acid lyase N-terminal fragment	Katsumata，R.et al.“Gene manifestation controlling DNA，”Patent：JP 1993056782-A 3 03/09/93
E04484						Prephenate dehydratase	Solouchi，N.et al.“Production of L-phenylalanine by ferrnentation，”Patent：JP 1993076352-A 2 03/30/93
	E05108		Aspartokinase	Fugono，N.et al.“Gene DNA coding Aspartokinase and its use，”Patent：JP 1993184366-A 1 07/27/93
E05112						Dihydro-dipichorinate synthetase	Hatakeyama，K.et al.“Gene DNA coding dihydrodipicolinic acid synthetase and its use，”Patent：JP 1993184371-A 1 07/27/93
	E05776		Diaminopimelic acid dehydrogenase	Kobayashi，M.et al.“Gene DNA coding Diaminopimelic acid dehydrogenase and its use，”Patent：JP 1993284970-A 1 11/02/93
E05779						Threonine synthase	Kohama，K.et al.“Gene DNA coding threonine synthase and its use，”Patent： JP 1993284972-A 1 11/02/93
	E06110		Prephenate dehydratase	Kikuchi，T.et al.“Production of L-phenylalanine by fermentation method，” Patent：JP 1993344881-A 1 12/27/93
E06111						Mutated Prephenate dehydratase	Kikuchi，T.et al.“Production of L-phenylalanine by fermentation method，” Patent：JP 1993344881-A 1 12/27/93
	E06146		Acetohydroxy acid synthetase	Inui，M.et al.“Gene capable of coding Acetohydroxy acid synthetase and its use，”Patent：JP 1993344893-A 1 12/27/93
E06825						Aspartokinase	Sugimoto，M.et al.“Mutant aspartokinase gene，”patent：JP 1994062866-A 1 03/08/94
	E06826		Mutated aspartokinase alpha subunit	Sugimoto，M.et al.“Mutant aspartokinase gene，”patent：JP 1994062866-A 1 03/08/94

Table 2 (continuation)
	E06827		Mutated aspartokinase alpha subunit	Sugimoto，M.et al.“Mutant aspartokinase gene，”patent：JP 1994062866-A 1 03/08/94
E07701					secY		Honno，N.et al.“Gene DNA participating in integration of membraneous protein to membrane，”Patent：JP 1994169780-A 1 06/21/94
	E08177		Aspartokinase	Sate，Y.et al.“Genetic DNA capable of coding Aspartokinase released from feedback inhibition and its utilization，”Patent：JP 1994261766-A 1 09/20/94
E08178， E08179， E08180， E08181， E08182						Feedback inhibition-released Aspartokinase	Sato，Y.et al.“Genetic DNA capable of coding Aspartokinase released from feedback inhibition and its utilization，”Patent：JP 1994261766-A 1 09/20/94
	E08232		Acetohydroxy-acid isomeroreductase	Inui，M.et al.“Gene DNA coding acetohydroxy acid isomeroreductase，” Patent：JP 1994277067-A 1 10/04/94
E08234					secE		Asai，Y.et al.“Gene DNA coding for translocation machinery of protein，” Patent：JP 1994277073-A 1 10/04/94
	E08643		FT aminotransferase and desthiobiotin synthetase promoter region	Hatakeyama，K.et al.“DNA fragment having promoter function in coryneform bacterium，”Patent：JP 1995031476-A 1 02/03/95
E08646						Biotin synthetase	Hatakeyam a，K.et al.“DNA fragment having promoter function in coryneform bacterium，”Patent：JP 1995031476-A 1 02/03/95
	E08649		Aspartase	Kohama，K.et al “DNA fragment having promoter function in coryneform bacterium，”Patent：JP 199503 1478-A 1 02/03/95
E08900						Dihydrodipicolinate reductase	Madori，M.et al.“DNA fragment containing gene coding Dihydrodipicolinate acid reductase and utilization thereof，”Patent：JP 1995075578-A 1 03/20/95
	E08901		Diaminopimelic acid decarboxylase	Madori，M.et al.“DNA fragment containing gene coding Diaminopimelic acid decarboxylase and utilization thereof，”Patent：JP 1995075579-A 1 03/20/95
E12594						Serine hydroxymethyltransferase	Hatakeyama，K.et al.“Production of L-trypophan，”Patent：JP 1997028391-A 1 02/04/97
	E12760， E12759， E12758		transposase	Moriya，M.et al.“Amplification of gene using artificial transposon，”Patent： JP 1997070291-A 03/18/97
E12764						Arginyl-tRNA synthetase；diaminopimelic acid decarboxylase	Moriya，M.et al.“Amplification of gene using artificial transposon，”Patent： JP 1997070291-A 03/18/97
	E12767		Dihydrodipicolinic acid synthetase	Moriya，M.et al.“Amplification of gene using artificial transposon，”Patent： JP 1997070291-A 03/18/97
E12770						aspartokinase	Moriya，M.et al.“Amplification of gene using artificial transposon，”Patent： JP 1997070291-A 03/18/97
	E12773		Dihydrodipicolinic acid reductase	Moriya，M.et al.“Amplification of gene using artificial transposon，”Patent： JP 1997070291-A 03/18/97

Table 2 (continuation)
	E13655		Glucose-6-phosphate dehydrogenase	Hatakeyama，K.et al.“Glucose-6-phosphate dehydrogenase and DNA capable of coding the same，”Patent：JP 1997224661-A 1 09/02/97
L01508					IlvA	Threonine dehydratase	Moeckel，B.et al.“Functional and structural analysis of the threonine dehydratase of Corynebacterium glutamicum，”J.Bacteriol.，174：8065-8072 (1992)
	L07603	EC 4.2.1.15	3-deoxy-D-arabinohePtulosonate-7- phosphate synthase	Chen，C.et al.“The cloning and nucleotide sequence of Corynebacterium glutamicum 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase gene，” FEMS Microbiol.Lett.，107：223-230(1993)
L09232					IlvB；ilvN；ilvC	Acetohydroxy acid synthase large subunit； Acetohydrexy acid synthase small subunit； Acetohydroxy acid isomeroreductase	Keilhauer，C.et al.“Isoleucine synthesis in Corynebacterium glutamicum： molecular analysis of the ilvB-ilvN-ilvC operon，”J.Bacteriol.，175(17)：5595- 5603(1993)
	L18874	PtsM	Phosphoenolpyruvate sugar phosphotransferase	Fouet，A et al.“Bacillus subtilis sucrose-specific enzyme II of the phosphotransferase system：expression in Escherichia coli and homology to enzymes II from enteric bacteria，”PNAS USA，84(24)：8773-8777(1987)；Lee， J.K.et al.“Nucleotide sequence of the gene encoding the Corynebacterium glutamicum mannose enzymell and analyses of the deduced protein sequence，”FEMS Microbiol.Lett.，119(1-2)：137-145(1994)
L27123					aceB	Malate synthase	Lee，H-S.et al.“Molecular characterization of aceB，agene encoding malate synthase in Corynebacterium glutamicum，”J.Microbiol.Biolechnol.， 4(4)：256-263(1994)
	L27126		Pyruvate kinase	Jetten，M.S.et al.“Structural and functional analysis of Pyruvate kinase from Corynebacterium glutamicum，”Appl.Environ Microbiol.，60(7)：2501-2507 (1994)
L28760					aceA	Isocitrate lyase
	L35906	dtxr	Diphtheria toxin repressor	Oguiza，J.A.et al.“Molecular cloning，DNA sequence analysis，and characlerization of the Corynebacterium diphtheriae dtxR from Brevibac：terium lactofermentum，”J.Bacteriol.，177(2)：465-467(1995)
M13774						Prephenate dehydratase	Follettie，M.T.et al.“Molecular cloning and nucleotide sequence of the Corynebacterium glutamicum pheA gene，”J.Bacteriol.，167：695-702(1980)
	M16174	5S rRNA		Park，Y-H.et al.“Phylogenetic analysis of the coryneform bacteria by 56 rRNA sequences，”J.Bacteriol.，169：180-1806(1987)
M16663					trpE	Anthranilate synthase，5’end	Sano，K.et al.“Structure and function of the trp operon control regions of Brevibacterium lactofermentum，a glutamic-acid-producing bacterium，”Gene， 52：191-200(1987)
	M16664	trpA	Tryptophan synthase，3’end	Sano，K.et al.“Structure and function of the trp operon control regions of Brevibacterium lactofermentum，a glutamic-acid-producing bacterium，”Gene， 52：191-200(1987)

Table 2 (continuation)
	M25819		Phosphoenolpyruvate carboxylase	O’Regan，M.et al.“Cloning and nucleotide sequence of the Phosphoenolpyruvate carboxylase-coding gene of Corynebacterium glutamicum ATCCl 3032，”Gene，77(2)：237-251(1989)
M85106						23S rRNA gene insertion sequence	Roller，C.et al.“Gram-positive bacteria with a high DNA G+C content are characterized by a common insertion within their 23S rRNA genes，”J.Gen. Microbiol.，138：1167-1175(1992)
	M85107， M85108		23S rRNA gene insertion sequence	Roller，C.et al.“Gram-positive bacteria with a high DNA G+C content are characterized by a common insertion within their 23S rRNA genes，”J.Gen. Microbiol.，138：1167-1175(1992)
M89931					aecD；bmQ；yhbw	Beta C-S lyase；branched-chain amino acid uptake carrier；hypothetical protein yhbw	Rossol，I.et al.“The Corynebacterium glutamicum aecD gene encodes a C-S Iyase with alpha，beta-elimination activity that degrades aminoethylcysteine，” J.Bacteriol.，174(9)：2968-2977(1992)；Tauch，A.et al.“Isoleucine uptake in Corynebacterium glutamicum ATCC 13032 is directed by the brnQ gene product，”Arch Microbiol.，169(4)：303-312(1998)
	S59299	trp	Leader gene(promoter)	Herry，D.M.et al.“Cloning of the trp gene cluster from a tryptophan- hyperproducing strain of Corynebacterium glutamicum：identification of a mutation in the trp leader sequence，”Appl.Environ.Microbiol.，59(3)：791-799 (1993)
U11545					trpD	Anthranilate phosphoribosyltransferase	O’Gara，J.P.and Dunican，L.K.(1994)Complete nucleotide sequence of the Corynebacterium glutamicum ATCC 21850 tpD gene.”Thesis，Microbiology Department，University College Galway，Ireland.
	U13922	cgllM；cgllR；clgllR	Putative type II 5-cytosoine methyltransferase；putative type II restriction endonuclease；putative type I or type III restriction endonuclease	Schafer，A.et al.“Cloning and characterization of a DNA region encoding a stress-sensitive restriction system from Corynebacterium glutamicum ATCC 13032 and analysis of its role in intergeneric coniugation with Escherichia coli，”J.Bacteriol.，176(23)：7309-7319(1994)；Schafer，A.et al.“The Corynebacterium glutamicum cgllM gene encoding a 5-cytosine in an McrBC- deffcient Escherichia coli strain，”Gene，203(2)：95-101(1997)
U14965					recA
	U31224	PPx		Ankri，S.et al.“Mutations in the Corynebacterium glutamicumproline biosynthetic pathway：A natural bypass of the proA step，”J.Bacteriol.， 178(15)：4412-4419(1996)
U31225					proC	L-proline：NADP+5-oxidoreductase	Ankri，S.et al.“Mutations in the Corynebacterium glutamicumproline biosynthetic pathway：A natural bypass of the proA step，”J.Bacterio1.， 178(15)：4412-4419(1996)
	U31230	obg；proB；unkdh	？；gamma glutamyl kinase；similar to D- isomer specific 2-hydroxyacid dehydrogenases	Ankri，S.et al.“Mutations in the Corynebacterium glutamicumproline biosynthetic pathway：A natural bypass of the proA step，”J.Bacteriol.， 178(15)：4412-4419(1996)

Table 2 (continuation)
	U31281	bioB	Biotin synthase	Serebriiskii，I.G.，“Two new members of the bio B superfamily：Cloning， sequencing and expression of bio B genes of Methylobacillus flagellatum and Corynebacterium glutamicum，”Gene，175：15-22(1996)
U35023					thtR：accBC	Thiosulfate sulfurtransferase；acyl CoA carboxylase	Jager，W.et al.“A Corynebacterium glutamicum gene encoding a two-domain protein simitar to biotin carboxylases and biotin-carboxyl-carrier proteins，” Arch Microbiol.，166(2)；76-82(1996)
	U43535	cmr	Multidrug resistance protein	Jager，W.et al.“A Corynebacterium glutamicum gene conferring multidrug resistance in the heterologous host Escherichia coli，”J.Bacteriol.， 179(7)：2449-2451(1997)
U43536					clpB	Heat shock ATP-binding protein
	U53587	aphA-3	3’5”-aminoglycoside phosphotransferase
U89648						Corynebacterium glutamicum unidentified sequence involved in histidine biosynthesis， partial sequence
	X04960	trpA；trpB；trpC；trpD； trpE；trpG；trpL	Tryptophan operon	Matsui，K.et al.“Complete nucleotide and deduced amino acid sequences of the Brevibacterium lactofermentum tryptophan operon，”Nucleic Acids Res.， 14(24)：10113-10114(1986)
X07563					lysA	DAP decarboxylase(meso-diaminopimelate decarboxylase，EC 4.1.1.20)	Yeh，P.et al.“Nucleic sequence of the lysA gene of Corynebacterium glutamicum and possible mechanisms for modulation of its expression，”Mol. Gen.Genet.，212(1)：112-119(1988)
	X14234	EC4.1.1.31	Phosphoenolpyruvate carboxylase	Eikmanns，B.J.et al.“The Phosphoenolpyruvate carboxylase gene of Corynebacterium glutamicum：Molecular cloning，nucleotide sequence，and expression，”Mol.Gen.Genet.，218(2)：330-339(1989)；Lepiniec，L.et al. “Sorghum Phosphoenolpyruvate carboxylase gene family：structure；function and molecular evolution，”Plant.Mol.Biol.，21(3)：487-502(1993)
X17313					fda	Fructose-bisphosphate aldolase	Von der Osten，C.H.et al.“Molecular cloning，nucleotide sequence and fine- structural analysis of the Corynebacterium glutamicum fda gene：structural comparison of C.glutamicum fructose-1，6-biphosphate aldolase to class I and class II aldolases，”Mol.Microbiol.，
	X53993	dapA	L-2，3-dihydrodipicolinate synthetase(EC 4.2.1.52)	Bonnassie，S.et al.“Nucleic sequence of the dapA gene from Corynebacterium glutamicum，”Nucleic Acids Res.，18(21)：6421(1990)
X54223						AttB-related site	Cianciotto，N.et al.“DNA sequence homology between att B-related sites of Corynebacterium diphtheriae，Corynebacterium ulcerans，Corynebacterium glutamicum，and the attP site of lambdacorynephage，”FEMS.Microbiol. Leu.，66：299-302(1990)
	X54740	argS；lysA	Arginyl-tRNA synthetase；Diaminopimelate decarboxylase	Marcel，T.et al.“Nucleotide sequence and organization of the upstream region of the Corynebacterium glutamicum lysA gene，”Mol.Microbiol.，4(11)：1819- 1830(1990)

Table 2 (continuation)
	X55994	trpL；trpE	Putatiye leader peptide；anthranilste synthase component I	Heery，D.M.et al.“Nucleotide sequence of the Corynebacterium glutamicum trpE gene，”Nucleic Acids Res.，18(23)：7138(1990)
X56037					thrC	Threonine synthase	Han，K S.et al.“The molecular structure of the Corynebacterium glutamicum tnreonine syntnase gene，Mol.Microbiol.，4(10)：1693-1702(1990)
	X56075	attB-related site	Attachment site	Cianciotto，N.et al.“DNA sequence homology between att B-related sites of Corynebacterium diohtheriae，Corynebacterium ulcerans Corynehacterium grutarmicum，and the attP stte or tambdacorynepnage，”FEMS.Microbiol， Lett.，66：299-302(1990)
X57226					lysC-alpha；lysC-beta； asd	Aspartokinase-alpha subunit； Aspartokinase-beta subunit；asparate beta semialdehyde dehydrogenase	Kalinowski，J.et al.“Genetic and biochemical analvsis of the Aspartokinase Irom Corynebacterium glutamicum.”Mol. Microbiol 5(5)1197-1204(1991)- Kannowski，J.et al.Aspartokinase genes lysC aloha and lysC beta overlan and are aqjacent to the aspertate beta-semialdehyde dehydrogenase gene asd in Corynebacterium glutamicum，”Mol. Gen.Genet.，224(3)：317-324(1990)
	X59403	gap；pgk；tpi	Glyceraldehyde-3-phosphate； phosphoglycerate kinase；triosephosphate isomerase	Eikmanns，B.J.“Identification，sequence analvsis.and expression of a Corvnebacterium glutamicum gene cluster encoding the three glycolvtic enzymes glyceraldehyde-3-phosohate dehydrogenase 3-nbosnhnglycerate kinase.and triosephosphate isomeras，J.Bacteriol.，174(19)：6076-6086 (1992)
X59404					gdh	Glutamate dehydrogenase	Bormann.E.R.et al.“Molecular analvsis of the Corynebacterium plutamicum gdh gene encoding glutamate dehydrogenase，”Mol.Microbiol.，6(3)：317-326 (1992)
	X60312	lysl	L-lysine permease	Seep-Feldhaus，A.H.et al.“Molecular analysis of the Corynebacterium glutamicum lysl gene involved in lysine uptake，”Mol.Microbioll.(12)-2995- 3005(1991)
X66078					copl	Psl protein	Joliff G.et al.“Cloning and nucleotide sequence of the cspl gene encoding PS1，one or the two maior secreteo proteins or Corvnebacterium glutamicum： The deduced N-terminal region of PSI is similar to the Mycobacterium antigen 85 complex，”Mol.Microbiol.，6(16)：2349-2362(1992)
	X66112	glt	Citrate synthase	Eikmanns，B.J.et al.“Cloning sequence，expression and transcriptional analysts or the Corynebacterium glutamicum gltA gene encoding citrate synthase，”Microbiol.，140：1817-1828(1994)
X67737					dapB	Dihydrodipicolinate reductase
	X69103	csp2	Surface layer protein PS2	Peyret，J.L.et al.“Characterization of the cspB gene encoding PS2，an ordered surface-layer protein in Corynebacterium glutarnicum，”Mol.Microbiol.， 9(1)：97-109(1993)
X69104						IS3 related insertion element	Bonamy，C.et al.“Identification of ISI 206，a Corynebacterium glutamicum IS3-related insertion sequence and phylogenetic analysis，”Mol.Microbiol.， 14(3)：571-581(1994)

Table 2 (continuation)
	X70959	leuA	Isopropylmalate synthase	Patek，M.et al.“Leucine synthesisin Corynebacterium glutamicum-enzyme activities，structure of leuA，and effect of leuA inactivation on lysinre synthesis，”Appl.Emiron Microbiol.，60(1)：133-140(1994)
X71489					icd	Isocitrate dehydrogenase(NADP+)	Eikmanns，B.J.et al.“Cloning sequence analysis，expression，and inactivation of the Corynebacterium glutamicum icd gene encoding isocitrate dehydrogenase and biochemical characterization of the enzyme，”J.Bacteriol.， 177(3)：774-782(1995)
	X72855	GDHA	Glutamate dehydrogenase(NADP+)
X75083， X70584					mtrA	5-methyltryptoPhan resistance	Heery，D.M.et al.“A sequence from a tryptophan-hyperproducing strain of Corynebacterium glutamicum erncoding resistance to 5-methyltryptophan，” Biochem.Biophys.Res.Commun.，201(3)：1255-1262(1994)
	X75085	recA		Fitzpatrick，R.et al.“Construction and characterization of recA mutant strains of Corynebacterium glutamicum and Brevibacterium lactofermentum，”Appl. Microbiol.Biotechnol.，42(4)：575-580(1994)
X75504					aceA：thiX	Partial Isocitrate lyase：？	Reinscheid，D.J.et al.“Characterization of the isocitrate lyase gene from Corynebacterium glutamicum and biochemical analysis of the enzyme，”J. Bacteriol.，176(12)：3474-3483(1994)
	X76875		ATPase beta-subunit	Ludwig，W.et al.“Phylogenetic relationships of bacteria based on comparative sequence analysis of elongation factor Tu and ATP-synthase beta-subunit genes，”Antonie Van leeuwenhoek，64：285-305(1993)
X77034					tuf	Elongation factor Tu	Ludwig，W.et al.“Phylogenetic relationships of bacteria based on comparative sequence analysis of elongation factor Tu and ATP-synthase beta-subunit genes，”Antonie Van Leeuwenhoek，64：285-305(1993)
	X77384	recA		Billman-Jacobe，H.“Nucleotide sequence of a recA gene from Corynebacterium glutamicum，”DNA Seq.，4(6)：403-404(1994)
X78491					aceB	Malate synthase	Reinscheid，D.J.et al.“Malate synthase from Corynebacterium glutamicun pta-ack operon encoding phosphotransacetylase：sequence analysis，” Microbiology，140：3099-3108(1994)
	X80629	16S rDNA	16S ribosomal RNA	Rainey，F.A.et al.“Phylogenetic analysis of the genera Rhodococcus and Norcardia and evidence for the evolutionary origin of the genus Norcardia from within the radiation of Rhodococcus species，”Microbiol.，141：523-528 (1995)
X81191					gluA；gluB；gluC； gluD	Glutamate uptake system	Kroreneyer，W.et al.“Structure of the gluABCD cluster encoding the glutamate uptake system of Corynebacterium glutarmicum，”J.Bacteriol.， 177(5)：1152-1158(1995)
	X81379	dapE	Succinyldiaminopimelate desuccinylase	Wehrmann，A.et al.“Analysis of different DNA fragments of Corynebacteriun glutamicum complementing dapE of Escherichia coli，” Microbiology，40：3349-56(1994)

Table 2 (continuation)
	X82061	16S rDNA	16S ribosomal RNA	Ruimy，R.et al.“Phylogeny of the genus Corynebacterium deduced from analyses of small-subunit ribosomal DNA sequences，”Int.J.Syst.Bacteriol.， 45(4)：740-746(1995)
X82928					asd；lysC	Aspartate-semialdehyde dehydrogenase：？	Serebrijski，I.et al.“Multicopy suppression by asd gene and osmotic stress- dependent complemeotation by heterologous proA in proA mutants，”J. Bacteriol.，177(24)：7255-7260(1995)
	X82929	proA	Gamma-glutamyl phosphate reductase	Serebrijski，I.et al.“Multicopy suppression by asd gene and osmotic stress- dependent complementation by heterologous proA in proA mutants，”J. Bacteriol.，177(24)：7255-7260(1995)
X84257					16S rDNA	16S ribosomal RNA	Pascual，C.et al.“Phylogenetic analysis of the genus Corynebacterium based on 16S rRNA gene sequences，”Int.J.Syst.Bacteriol.，45(4)：724-728(1995)
	X85965	aroP；dapE	Aromatic amino acid permease；？	Wehrmann et al.“Functional analysis of sequences adjacent to dapE of C. glutamicum proline reveals the presence of aroP，which encodes the aromatic amino acid transporter，”J.Bacteriol.，177(20)：5991-5993(1995)
X86157					argB；argC；argD； argF；argJ	Acetylglutamate kinase；N-acetyl-gamma- glutamyl-phosphate reductase； acetylornithine aminotransferase；ornithine carbamoyltransferase；glutamate N- acetyltransferase	Sakanyan，V.et al.“Genes and enzymes of the acetyl cycle of arginine biosynthesis in Corynebacterium glutamicum：enzyme evolution in the early steps of the arginine pathway，”Microbiology，142：99-108(1996)
	X89084	pta；ackA	Phosphate acetyltransferase；acetate kinase	Reinscheid，D.J.et al.“Cloning，sequence aralysis，expression and inactivation of the Corynebacterium glutamicum pta-ack operon encoding phosphotransacetylase and acetate kinase，”Microbiology，145：503-513(1999)
X89850					attB	Attachment site	Le Marrec，C.et al.“Genetic characterization of site-specific integration functions of phi AAU2 infecting“Arthrobacter anreus C70，”J.Bacteriol.， 178(7)：1996-2004(1996)
	X90356		Promoter fragment F1	Patek，M.et al.“Promoters from Corynebacterium glutamicum：cloning， molecular analysis and search for a consensus motif，”Microbiology， 142：1297-1309(1996)
X90357						Promoter fragment F2	Patek，M.et al.“Promoters from Corynebacterium glutamicun：cloning， molecular analysis and search for a consensus motif，”Microbiology， 142：1297-1309(1996)
	X90358		promoter fragment F10	Patek，M.et al.“Promoters from Corynebacterium glutamicun：cloning， molecular analysis and search for a consensus motif，”Microbiology， 142：1297-1309(1996)
X90359						Promoter fragment F13	Patek，M.et al.“Promoters from Corynebacteriurm glutanicum：cloning， molecular analysis and search for a consensus motif，”Microbiology， 142：1297-1309(1996)

Table 2 (continuation)
	X90360		Promoter fragment F22	Patek，M.et al.“Promoters from Corynebacterium glutamicum：cloning， molecular analysis and search for a consensus motif，”Microbiology， 142：1297-1309(1996)
X90361						Promoter fragment F34	Patek，M.et al.“Promoters from Corynebacterium glutamicum：cloning， molecular analysis and search for a consensus motif，”Microbiology， 142：1297-1309(1996)
	X90362		Promoter fragment F37	Patek，M.et al.“Promoters from C.glutamicum：cloning，molecular analysis and search for a consensus motif，”Microbiology，142：1297-1309(1996)
X90363						Promoter fragment F45	Patek，M.et al.“Promoters from Corynebacterium glutamicum：cloning， molecular analysis and search for a consensus motif，”Microbiology， 142：1297-1309(1996)
	X90364		Promoter fragment F64	Patek，M.et al.“Promoters from Corynebacterium glutamicum：cloning， molecular analysis and search for a consensus motif，”Microbiology， 142：1297-1309(1996)
X90365						Promoter fragment F75	Patek，M.et al.“Promoters from Corynebacterium glutamicum：cloning， molecular analysis and search for a consensus motif，”Microbiology， 142：1297-1309(1996)
	X90366		Promoter fragment PF101	Patek，M.et al.“Promoters from Corynebacterium glutamicum：cloning， molecular analysis and search for a consensus motif，“Microbiology， 142：1297-1309(1996)
X90367						Promoter fragment PF104	Patek，M.et al.“Promoters from Corynebacterium glutamicum：cloning， molecular analysis and search for a consensus motif，”Microbiology， 142：1297-1309(1996)
	X90368		Promoter fragment PF109	Patek，M.et al.“Promoters from Corynebacterium glutamicum：cloning， molecular analysis and search for a consensus motif，”Microbiology， 142：1297-1309(1996)
X93513					amt	Ammonium transport system	Siewe，R.M.et al.“Functional and genetic characterization of the(methyl) ammonium uptake carrier of Corynebacterium glutamicum，”J.Biol.Chem.， 271(10)：5398-5403(1996)
	X93514	betP	Glycine betaine transport system	Peter，H.et al.“Isolation，characterization，and expression of the Corynebacterium glutamicum betP gene，encoding the transport system for the compatible solute glycine betaine，”J.Bacteriol.，178(17)：5229-5234(1996)
X95649					orf4		Patek，M.et al.“Identification and transcriptional analysis of the dapB-ORF2- dapA-ORF4 operon of Corynebacterium glutamicum，encoding two enzymes involved in L-lysine synthesis，”Biotechnol.Lett.，19：1113-1117(1997)
	X96471	lysE；lysG	Lysine exporter protein；Lysine export regulator protein	Vrljic，M.et al.“A new type of transporter with a new type of cellular function：L-lysine export from Corynebaeterium glutamicum，”Mol. Microbiol.，22(5)：815-826(1996)

Table 2 (continuation)
	X96580	panB；panC；xylC	3-methyl-2-oxobutanoate hydroxymethyftransferase；pantoate-beta- alanine ligase；xylulokinase	Sahm，H.et al.“D-pantothenate synthesis in Corynebacterium glutamicum and use of panBC and genes encoding L-valine synthesis for D-pantothenate overproduction，”Appl.Environ.Microbiol.，65(5)：1973-1979(1999)
X96962						Insertion sequence ISI207 and transposase
	X99289		Elongation factor P	Ramos，A.et al.“Cloning，sequencing and expression of the gene encoding elongation factor P in the amino-acid producer Brevibacterium lactofermentum (Corynebacterium glutamicum ATCC 13869)，”Gene，198：217-222(1997)
Y00140					thrB	Homoserine kinase	Mateos，L.M.et al.“Nucleotide seouence of the homoserine kinase (thrB) gene of ule Dtevioacterium taclorermentum，Nucleic Aclas Kes.，15(9)：3922(1987)
	Y00151	ddh	Meso-diaminopimelate D-dehydrogenase (EC 1.4.1.16)	Ishino，S.et al.“Nucleotide sequence of the meso-diaminopimelate D- dehydrogenase gene from Corynebacterium glutamicum，”Nucleic Acids Res.， 15(9)：3917(1987)
Y00476					thrA	Homoserine dehydrogenase	Mateos，L.M.et al.“Nucleotide sequence of the homoserine dehydrogenase (thrA) gene of the Brevibacterium lactofermentum，”Nucleic Acids Res.， 15(24)：10598(1987)
	Y00546	hom：thrB	Homoserine dehydrogenase；homoserine kinase	Peoples，O.P.et al.“Nucleotide sequence and fine structural analysis of the Corynebacterium glutamicum hom-thrB operon，”Mol. Microbiol.，2(1)：63-72 (1988)
Y08964					murC；ftsQ/divD；ftsZ	UPD-N-acetylmuramate-alanine ligase： division initiation protein or cell division protein；cell division protein	Honruibia，M.P.et al.“Identification，characterization，and chromosomal organization of the ftsZ gene from Brevibacte rium lactofennentum，”Mol. Gen. Genet.，259(1)：97-104(1998)
	Y09163	putP	High affinity proline transport system	Peter，H.et al.“Isolation of the putP gene of Corynebacterium glutamicumproline and characterization of a low-affinity uptake system for compatible solutes，”Arch.Microbiol.，168(2)：143-151(1997)
Y09548					pyc	Pyruvate carboxylase	Peters-Wendisch，P.G.et al.“Pyruvate carboxylase from Corynebacterium glutamicum：characterization，expression and inactivation of the pyc gene，” Microbiology，144：915-927(1998)
	Y09578	leuB	3-isopropylmalate dehydrogenase	Patek，M.et al.“Analysis of the leuB gene from Corynebacterium glutarnicum，”Appl. Microbiol.Biotechnol.，50(1)：42-47(1998)
Y12472						Attachment site bacteriophage Phi-16	Moreau，S.et al.“Site-specific integration of corynephage Phi-16：The construction of an integration vector”Microbiol.，145：539-548(1999)
	Y12537	proP	Proline/ectoine uptake system protein	Peter，H.et al.“Corynebacterium glutamicum is equipped with four secondary carriers for compatible solutes：ldentification，sequencing，and characterization of the proline/ectoine uptake system，ProP，and the ectoine/proline/gycine betaine carrier，EctP，”J.Bacteriol.，180(22)：6005-6012(1998)

Table 2 (continuation)
	Y13221	glnA	Glutamine synthetase I	Jakoby，M.et al.“Isolation of Corynebacterium glutamicum glnA gene encoding glutamine synthetase I，”FEMS Microbiol.Lett.，154(1)：81-88(1997)
Y16642					lpd	Dihydrolipoamide dehydrogenase
	Y18059		Attachment site Corynephage 304L	Moreau，S.et al.“Analysis of the integration functions of &phi；304L：An integrase module among corynephages，”Virology，255(1)：150-159(1999)
Z21501					argS；lysA	Arginyl-tRNA synthetase；diaminopimelate decarboxylase(partial)	Oguiza，J.A.et al.“A gene encoding arginyl-tRNA synthetase is located in the upstream region of the lysA gene in Brevibacterium lactofermentum： Regulation of argS-lysA cluster expression by arginine，”J. Bacteriol.，175(22)：7356-7362(1993)
	Z21502	dapA；dapB	Dihydrodipicolinate synthase； dihydrodipicolinate reductase	Pisabarro，A.et al.“A cluster of three genes(dapA，orf2，and dapB)of Brevibacterium lactofermentum encodes dihydrodipicolinate reductase，and a third polypeptide of unknown function，”J.Bacteriol.，175(9)：2743-2749 (1993)
Z29563					thrC	Threonine synthase	Malumbres，M.et al.“Analysis and expression of the thrC gene of the encoded threonine synthase，”Appl. Environ.Microbiol.，60(7)2209-2219(1994)
	Z46753	16S rDNA	Gene for 16S ribosomal RNA
Z49822					sigA	SigA sigma factor	Oguiza，J.A.et al“Multiple sigma factor genes in Brevibacterium lactofermentum：Characterization of sigA and sigB，”J.Bacteriol.，178(2)：550- 553(1996)
	Z49823	galE；dtxR	Catalytic activity UDP-galactose 4- epimerase；diphtheria toxin regulatory protein	Oguiza，J.A.et al“The galE gene encoding the UDP-galactose 4-epimerase of Brevibacterium lactofermtum is coupled transcriptionally to the dmdR gene，”Gene，177：103-107(1996)
Z49824					orfI；sigB	？；SigB sigma factor	Oguiza，J.A.et al“Multiple sigma factor genes in Brevibacterium lactofermentum：Characterization of sigA and sigB，”J.Bacteriol.，178(2)：550- 553(1996)
	Z66534		Transposase	Correia，A.et al.“Cloning and characterization of an IS-like element present in the genome of Brevibacterium lactofermentum ATCC 13869，”Gene， 170(1)：91-94(1996)
The gene sequence is disclosed in the cited literature. However, the sequences obtained by the inventors of the present application are significantly longer than the published sequences. Supposing that the public sequence starts a cryptographic error, it is only A fragment of the actual coding region.

Table 3: corynebacterium and Brevibacterium useful for practicing the present invention

Name of the genus	Seed name	ATCC	FERM	NRRI	CRCT	NCIMB	CBS	NCTC	DSMZ
										Brevibacterium	ammoniagenes	21054
Brevibacterium	ammoniagenes	19350
										Brevibacterium	ammoniagenes	19351
Brevibacterium	ammoniagenes	19352
										Brevibacterium	ammoniagenes	19353
Brevibacterium	ammoniagenes	19354
										Brevibacterium	ammoniagenes	19355
Brevibacterium	ammoniagenes	19356
										Brevibacterium	ammoniagenes	21055
Brevibacterium	ammoniagenes	21077
										Brevibacterium	ammoniagenes	21553
Brevibacterium	ammoniagenes	21580
										Brevibacterium	ammoniagenes	39101
Brevibacterium	butanicum	21196
										Brevibacterium	divaricatum	21792	P928
Brevibacterium	flavum	21474
										Brevibacterium	flavum	21129
Brevibacterium	flavum	21518
										Brevibacterium	flavum			B11474
Brevibacterium	flavum			B11472
										Brevibacterium	flavum	21127
Brevibacterium	flavum	21128
										Brevibacterium	flavum	21427
Brevibacterium	flavum	21475
										Brevibacterium	flavum	21517
Brevibacterium	flavum	21528
										Brevibacterium	flavum	21529
Brevibacterium	flavum			B11477
										Brevibacterium	flavum			B11478
Brevibacterium	flavum	21127
										Brevibacterium	flavum			B11474
Brevibacterium	healii	15527
										Brevibacterium	ketoglutamicum	21004
Brevibacterium	ketoglutamicum	21089
										Brevibacterium	ketosoreductum	21914
Brevibacterium	lactofermentum				70
										Brevibacterium	lactofermentum				74
Brevibacterium	lactofermentum				77
										Brevibacterium	lactofermentum	21798
Brevibacterium	lactofermentum	21799
										Brevibacterium	lactofermentum	21800
Brevibacterium	lactofermentum	21801
										Brevibacterium	lactofermentum			B11470
Brevibacterium	lactofermentum			B11471

Name of the genus	Seed name	ATCC	FERM	NRRL	CECT	NCIMB	CBS	NCTC	DSMZ
										Brevibacterium	lactofermentum	21086
Brevibacterium	lactofermentum	21420
										Brevibacterium	lactofermentum	21086
Brevibacterium	lactofermentum	31269
										Brevibacrerium	linens	9174
Brevibacterium	linens	19391
										Brevibacterium	linens	8377
Brevibacterium	paraffinolyticum					11160
										Brevibacterium	spec.						717.73
Brevibacterium	spec.						717.73
										Brevibacterium	spec.	14604
Brevibacterium	spec.	21860
										Brevibacterium	spec.	21864
Brevibacterium	spec.	21865
										Brevibacterium	spec.	21866
Brevibacterium	spec.	19240
										Corynebacterium	acetoacidophilum	21476
Corynebacterium	acetoacidophilum	13870
										Corynebacterium	acetoglutamicum			B11473
Corynebacterium	acetoglutamicum			B11475
										Corynebacterium	acetoglutamicum	15806
Corynebacterium	acetoglutamicum	21491
										Corynebacterium	acetoglutamicum	31270
Corynebacterium	acetophilum			B3671
										Corynebacterium	ammoniagenes	6872						2399
Corynebacterium	ammoniagenes	15511
										Corynebacterium	fujiokense	21496
Corynebacterium	glutamicum	14067
										Corynebacterium	glutamicum	39137
Corynebacterium	glutamicum	21254
										Corynebacterium	glutamicum	21255
Corynebacterium	glutamicum	31830
										Corynebacterium	glutamicum	13032
Corynebacterium	glutamicum	14305
										Corynebacterium	glutamicum	15455
Corynebacterium	glutamicum	13058
										Corynebacterium	glutamicum	13059
Corynebacterium	glutamicum	13060
										Corynebacterium	gluramicum	21492
Corynebacterium	glutamicum	21513
										Corynebacterium	glutamicum	21526
Corynebacterium	glutamicum	21543
										Corynebacterium	glutamicum	13287
Corynebacterium	glutamicum	21851
										Corynebacterium	glutamicum	21253
Corynebacterium	glutamicum	21514
										Corynebacterium	glutamicum	21516
Corynebacterium	glutamicum	21299

Name of the genus	Seed name	ATCC	FERM	NRRL	CECT	NCIMB	CBS	NCTC	DSMZ
										Corynebacterium	glutamicum	21300
Corynebacterium	glutamicum	39684
										Corynebacterium	glutamicum	21488
Corynebacterium	glutamicum	21649
										Corynebacterium	glutamicum	21650
Corynebacterium	glutamicum	19223
										Corynebacterium	glutamicum	13869
Corynebacterium	glutamicum	21157
										Corynebacterium	glutamicum	21158
Corynebacterium	glutamicum	21159
										Corynebacterium	glutamicum	21355
Corynebacterium	glutamicum	31808
										Corynebacterium	glutamicum	21674
Corynebacterium	glutamicum	21562
										Corynebacterium	glutamicun	21563
Corynebacterium	glutamicum	21564
										Corynebacterium	glutamicum	21565
Corynebacterium	glutamicum	21566
										Corynebacterium	glutamicum	21567
Corynebacterium	glutamicum	21568
										Corynebacterium	glutamicum	21569
Corynebacterium	glutamicum	21570
										Corynebacterium	glutamicum	21571
Corynebacterium	glutamicum	21572
										Corynebacterium	glutamicum	21573
Cotynebacterium	glutamicum	21579
										Corynebacterium	glutamicum	19049
Corynebacterium	glutamicum	19050
										Corynebacterium	glutamicum	19051
Corynebacterium	glutamicum	19052
										Corynebacterium	glutamicum	19053
Corynebacterium	glutamicum	19054
										Corynebacterium	glutamicum	19055
Corynebacterium	glutamicum	19056
										Corynebacterium	glutamicum	19057
Corynebacterium	glutamicum	19058
										Corynebacterium	glutamicum	19059
Corynebacterium	glutamicum	19060
										Corynebacterium	glutamicum	19185
Corynebacterium	glutamicum	13286
										Corynebacterium	glutamicum	21515
Corynebacterium	glutamicum	21527
										Corynebacterium	glutamicum	21544
Corynebacterium	glutamicum	21492
										Corynebacterium	glutamicum			B8183
Corynebacterium	glutamicum			B8182
										Corynebacterium	glutamicum			B12416
Corynebacterium	glutamicum			B12417

Name of the genus	Seed name	ATCC	FERM	NRRL	CECT	NCIMB	CBS	NCTC	DSMZ
										Corynebacterium	glutamicum			B12418
Corynebacrerium	glutamicum			B11476
										Corynebacterium	glutamicum	21608
Corynebacterium	lilium		P973
										Corynebacterium	nitrilophilus	21419				11594
Corynebacterium	spec.		P4445
										Corynebacterium	spec.		P4446
Corynebacterium	spec.	31088
										Corynebacterium	spec.	31089
Corynebacterium	spec.	31090
										Corynebacterium	spec.	31090
Corynebacterium	spec.	31090
										Corynebacterium	spec.	15954							20145
Corynebacterium	spec.	21857
										Corynebacterium	spec.	21862
Corynebacterium	spec.	21863

ATCC: american type culture collection, Rockville, MD, USAFERM: institute for fermentation, Chiba, japan nrrl: ARS agricultural research institute collection, NRRL, Peoria, IL, USACECT: classical spanish culture, Valencia, spanish NCIMB: national industrial and marine microorganism collection ltd, Aberdeen, UKCBS: fungus strainCollection, Baarn, NLNCTC: national culture and culture Collection, London, UKDSMZ: deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH, Braunschweig, Germany

See, Sugawara, H.et al, (1993) World direction of collections of cultures of microorganisms: bacteria, fungi and yeases (4)^thedn)，World federation for culture collections worlddata center on microorganisms，Saimata，Japen.

Table 4: sequence comparison result ID # Length hit result Length search number Genbank hit name Genbank hit Source homology Bank date

(NT) (GAp)rxa00023 3579 GB_EST33：A1776129 483 A1776129 EST257217 tomato resistant，Cornell Lycopersicon esculentum cDNA clone Lycopersicon esculentum 40,956 29-Jun-99

cLER17D3，mRNA sequence.

GB_EST33：A1776129 483 A1776129 EST257217 tomato resistant，Cornell Lycopersicon esculentum cDNA clone Lycopersicon esculentum 40,956 29-Jun-99

cLER17D3，mRNA sequence.rxa00044 1059 EM_PAT：E11760 6911 E11760 Base sequence of sucrase gene. Corynebacterium 42,979 08-OCT-

glutamicum 1997(Rel.

52，Created)

GB_PAT：126124 6911 126124 Sequence 4 from patent US 5556776. Unknown. 42,979 07-OCT-

1996

GB_BA2：ECOUVV89 176195 U00006 E. coli chromosomal region from 89.2 to 92.8 minutes. Escherichia coli 39,097 17-DEC-

1993rxa00064 1401 GB_PAT：E16763 2517 E16763 gDNA encoding aspartate transferase (AAT). Corynebacterium 95,429 28-Jul-99

glutamicum

GB_HTG2：AC007892 134257 AC007892 Drosophila melanogaster chromosome 3 clone BACR02O03 (D797) RPCI-99 Drosophila melanogaster 31,111 2-Aug-99

02.O.3 map 99B-99B strain y；cn bw sp，^***SEQUENCING IN PROGRESS

^***，113 unordered pieces.

GB_HTG2：AC007892 134257 AC007892 Drosophila melanogsater chromosome 3 clone BACR02O03 (D797) RPCI-98 Drosophila metenogaster 31,111 2-Aug-99

02.O.3 map 99B-99B strain y；cn bw sp，^***SEQUENCING IN

PROGRESS^***，113 unordered pieces. rxa00072rxa00105 798 GB_BA1：MTV002 56414 AL008967 Mycobacterium tuberculosis H37Rv complete genome；segment 122/162. Mycobecterium 37,753 17-Jun-98

tuberculosis

GB_BA1：ECU29581 71128 U29581 Escherichia coli K-12 genome，approximately 63 to 64 minutes. Escherichia coli 35,669 14-Jan-97

GB_BA2：AE000366 10405 AE000366 Escherichia coli K-12 MG1655 section 256 of 400 of the complete genome. Escherichia coli 35,669 12-Nov-98rxa00106 579 GB_EST15：AA494237 367 AA494237 ng83f04.s1 NCI_CGAP_Pr6 Homo sapiens cDNA clone IMAGE：941407 Homo sapiens 42,896 20-Aug-97

similar to SW：DYR_LACCA P00381 DIHYDROFOLATE REDUCTASE；，

mRNA sequence.

GB_BA2：AF161327 2021 AF161327 Corynebacterium diphtheriae histidine kinase ChrS (chrS) and response Corynebacterium 40,210 9-Sep-99

regulator ChrA (chrA) genes，complete cds. diphtheriae

GB_PAT：AR041189 654 AR041189 Sequence 4 from patent US 5811286. Unknown. 41,176 29-Sep-99rxa00115 1170 GB_PR4：AC007110 148336 AC007110 Homo sapiens chromosome 17.clone hRPK.472_J_18，complete sequence. Homo sapiens 36,783 30-MAR-

1999

GB_HTG3：AC006537 170030 AC008537 Homo sapiens chromosome 19 clone CIT-HSPC_490E21，^***SEQUENCING Homo sapiens 40,296 2-Sep-99

IN PROGRESS^***，93 unordered pieces.

GB_HTG3：AC008537 170030 AC008537 Homo sapiens chromosome 19 clone ClT-HSPC_490E21，^***SEQUENCING Homo sapiens 40,296 2-Sep-99

IN PROGRESS^***，93 unordered pieces.

Table 4 (continuation) rxa 001161284 GB _ BA 2: AF 06234516458 AF062345 Caulobacter crescentus Sst1 (Sst1), S-layer protein subunt (rsaA), ABC Caulobacter crescentus 36,23519-OCT-

transporter(rsaD)，membrane forming unit (rsaE)，putative GDP-mannose-4，6- 1999

dehydratase(lpsA)，putative acetyltransferase(lpsB)，putative perosamine

synthetase(lpsC)，putative mannosyltransferase(lpsD)，putative

mannosyltransferase(lpsE)，outer membrane protein(rsaF)，and putative

perosamine transferase(lpsE) genes，complete cds.

GB_PAT：118647 3300 118647 Sequence 6 from patent US 5500353. Unknown. 36,821 07-OCT-

1996

GB_GSS13：AQ44619 751 AQ446197 nbxb0062D16r CUGI Rice BAC Library Oryza sativa genomic clone Oryza sativa 38,124 8-Apr-99

7 nbxb0062D16r，genomic survey sequence.rxa00131 732 GB_BA1：MTY20B11 36330 Z95121 Mycobacterium tuberculosis H37Rv complete genome；segment 139/162. Mycobacterium 43,571 17-Jun-98

tuberculosis

GB_BA1：SAR7932 15176 AJ007932 Streptomyces argillaceus mithramycin biosynthetic genes. Streptomyces argillaceus 41,116 15-Jun-99

GB_BA1：MTY20B11 36330 Z95121 Mycobacterium tuberculosis H37Rv complete genome；segment 139/162. Mycobacterium 39,726 17-Jun-98

tuberculosisrxa00132 1557 GB_BA1：MTY20B11 36330 Z95121 Mycobacterium tuberculosis H37Rv complete genome；segment 139/162. Mycobacterium 36,788 17-Jun-98

tuberculosis

GB_IN2：TVU40872 1882 U40872 Trichomonas vaginalis S-adenosyl-L-homocysteine hydrolase gene，complete Trichomonas vaginalis 61,914 31-OCT-

cds. 1996

GB_HTG6：AC010706 169265 AC010706 Drosophila melanogester chromosome X clone BACR36D15(D887)RPC1-98 Drosophila melanogaster 51,325 22-Nov-99

36.D.15 map 13C-13E strain y；cn bw sp，^***SEQUENCING IN PROGRESS

^***，74 unordered pieces.rxa00145 1059 GB_BA1：MTCY2B12 20431 Z81011 Mycobacterium tuberculosis H37Rv complete genome；segment 61/162. Mycobacterium 63,365 18-Jun-98

tuberculosis

GB_BA1：PSEPYRBX 2273 L19649 Pseudomonas aeruginosa aspartete transcarbamoylase (pyrB) and Pseudomonas aeruginosa 56,080 26-Jul-93

dihydroorotase-like (pyrX) genes， complete cds′s.

GB_BA1：LLPYRBDNA 1468 X84262 L.leichmannii pyr8 gene. Lactobacilus leichmannii 47,514 29-Aor-97rxa00146 1464 GB_BA1：MTCY2B12 20431 Z81011 Mycobacterium tuberculosis H37Rv complete genome；segment 61/162. Mycobacterium 60,714 18-Jun-98

tuberculosis

GB_BA1：MTCY154 13935 Z98209 Mycobacterium tuberculosis H37Rv complete genome；segment 121/162. Mycobacterium 39,229 17-Jun-98

tuberculosis

GB_BA1：MSGY154 40221 AD000002 Mycobacterium tuberculosis sequence from clone y154. Mycobacterium 36,618 03-DEC-

tuberculosis 1996rxa00147 1302 GB_BA1：MTCY2B12 20431 Z81011 Mycobacterium tuberculosis H37Rv complete genorne；segment 61/162. Mycobacterium 61,527 18-Jun-98

tuberculosis

GB_BA1：MSG8937C 38914 L78820 Mycobacterium leprae cosmid B937 DNA sequence. Mycobacterium leprae 59,538 15-Jun-96

S

GB_BA1：PAU81259 7285 U81259 Pseudomones aeruginosa dihydrodipicolinate recluctase (dapB) gene.partial Pseudomonas aeruginosa 55,396 23-DEC-

cds，carbamoylphosphate synthetase small subunit (carA) and 1996

carbamoylphosphate synthetase large subunit (carB) genes，complete cds，

and FtsJ homolog (ftsJ) gene，partial cds.rxa00156 1233 GB_BA1：SC9B10 33320 AL009204 Streptomyces coelicolor cosmid 9B10. Streptomyces coelicolor 52,666 10-Feb-99

Table 4 (continuation)

GB_BA2：AF002133 15437 AF002133 Mycobacterium avium strain GIR10 transcriptional regulator (mav81) gene， Mycobacterium avium 54,191 26-MAR-

partial cds，aconitase (acn)，invasin 1 (inv1)，invasin 2 (inv2)，transcriptional 1998

regulator (moxR)，ketoacyl-reductase (fabG)，enoyl-reductase (inhA) and

ferrochelatase (mav272) genes，complete cds.

GB_BA1：D85417 7984 D85417 Propionioacterium freudenreichii hemY，hemH，hemB，hemX，hemR and Propionibacterium 46,667 6-Feb-99

hemL genes，complete cds. freudenreichiirxa00166 783 GB_HTG3：AC008167 174223 AC008167 Homo sapiens clone NH0172O13，^***SEQUENCING IN PROGRESS^***，7 Homo sapiens 37,451 21-Aug-99

unordered pieces.

GB_HTG3：AC008167 174223 AC008167 Homo sapiens clone NH0172O13，^***SEQUENCING IN PROGRESS^***，7 Homo sapiens 37,451 21-Aug-99

unordered pieces.

GB_HTG4：AC010118 80605 AC010118 Drosophila melanogaster chromosome 3L/62B1 clone RPCI98-10D15，^***Drosophila melanogaster 38,627 16-OCT-

SEQUENCING IN PROGRESS^***，51 unordered pieces. 1999rxa00198 672 GB_BA1：AB024708 8734 AB024708 Corynebacterium glutamicun gltB and gilD genes for glutamine 2- Corynebacterium 92,113 13-MAR-

oxoglutarate aminotransferase large and small subunits，complele cds. glutamicum 1999

GB_BA1 ：AB024708 8734 AB024708 Corynebacterium glutamicum gltB and gltD genes for glutamine 2- Corynebaclerium 93,702 13-MAR-

oxoglutarate aminotransferase large and small subunits，complele cds. glutamicum 1999

GB_EST24：AI232702 528 AI232702 EST229390 Normalized rat kidney，Bento Soares Rattus sp.cDNA clone Rattus sp. 34,221 31-Jan-99

RKICF35 3′end，mRNA sequence.rxa00216 1113 GB_HTG2：HSDJ850E 117353 AL121758 Homo sapiens chromosome 20 clone RP5-850E9，^***SEQUENCING IN Homo sapiens 37,965 03-DEC-

9 PROGRESS^***，in unordered pieces. 1999

GB_HTG2：HSDJ850E 117353 AL121758 Homo sapiens chromosome 20 clone RP5-850E9，^***SEQUENCING IN Homo sapiens 37,965 03-DEC-

9 PROGRESS^***，in unordered pieces. 1999

GB_PR2：CNS01DSA 159400 AL121766 Human chromosome 14 DNA sequence^***IN PROGRESS^***BAC R-412H8 Homo sapiens 38,796 11-Nov-99

of RPCI-11 tibrary from chromosome 14 of Homo sapiens (Human)，complete

sequence.rxa00219 1065 GB_HTG2：AC005079 110000 AC005079 Homo sapiens clone RG252P22，^***SEQUENCING IN PROGRESS^***，3 Homo sapiens 38,227 22-Nov-98

_0 unordered pieces.

GB_HTG2：AC005079 110000 AC005079 Homo sapiens clone RG252P22，^***SEQUENCING IN PROGRESS^***，3 Homo sapiens 38,227 22-Nov-98

_1 unordered pieces.

GB_HTG2：AC005079 110000 AC005079 Homo sapiens clone RG252P22，^***SEQUENCING IN PROGRESS^***，3 Homo sapiens 38,227 22-Nov-98

_1 unordered pieces.rxa00223 1212 GB_BA1：PPEA3NIF 19771 X99694 Plasmid pEA3 nitrogen fixation genes. Enterobacter agglomerans 48,826 2-Aug-96

GB_BA2：AF128444 2477 AF128444 Rhodobacter capsulatus molybdenum cofactor biosynthetic gene cluster， Rhodobacter capsulatus 40,135 22-MAR-

partial sequence. 1999

GB_HTG4：AC010111 138938 AC010111 Drosophila melanogaster chromosome 3L/70C1 clone RPC198-9B18，^***Drosophila melanogaster 39,527 16-OCT-

SEQUENCING IN PROGRESS^***，64 unordered pieces. 1999rxa00229 803 GB_BA2：AF124518 1758 AF124518 Corynebacterium glutamicum 3-dehydroquinase (aroD) and shikimate Corynebacterium 98,237 18-MAY-

dehydrogenese (eroE) genes，complete cds. glutamicum 1999

GB_PR3：AC004593 150221 AC004593 Homo sapiens PAC clone DJ0964C11 from 7p14-p15，complete sequence. Homo sapiens 36,616 18-Apr-98

GB_HTG2：AC006907 188972 AC006907 Caenorhabditis elegans clone Y76B12，^***SEQUENCING IN PROGRESS^***， Caenorhabditis elegans 37,095 26-Feb-99

25 unordered pieces.rxa00241 1626 GB_BA1：CGLYS1 4232 X60312 C.glutamicum lyst gene for L-lysine permease. Corynebacterium 100,000 30-Jan-92

glutamicum

Table 4 (continuation)

GB_HTG1：PFMAL13P 192581 AL049180 Plasmodium falciparum chromosome 13 strain 3D7，^***SEQUENCING IN Plasmodium falciparum 34,947 11-Aug-99

1 PROGRESS^***，in unordered pieces.

GB_HTG1：PFMAL13P 192581 AL049180 Plasmodium falciparum chromosome 13 strain 3D7，^***SEQUENCING IN Plasmodium faiciparum 34,947 11-Aug-99

1 PROGRESS^***，in unordered pieces.rxa00262 1197 GB_IN2：EHU89655 3219 U89655 Entamoeba histoiytica unconventional myosin IB mRNA，complete cds. Entamoeba histolytica 36,496 23-MAY-

1997

GB_IN2：EHU89655 3219 U89655 Entamoeba histoiytica unconventional myosin IB mRNA，complete cds. Entamoeba histolytica 37,544 23-MAY-

1997rxa00266 531 GB_RO：AF016190 2939 AF016190 Mus musculus connexin-36 (Cx36) gene，complete cds. Mus musculus 41,856 9-Feb-99

EM_PAT：E09719 3505 E09719 DNA encoding precursor protein of alkaline cellulase. Bacillus sp. 34,741 08-OCT-

1997 (Rel

52，Created)

GB_PAT：E02133 3494 E02133 gDNA encoding alkaline cellulase. Bacillus sp. 34,741 29-Sep-97rxa00278 1155 GB_IN1：CELK05F6 36912 AF040653 Caenorhabditis elegans cosmld K05F6. Caenorhabditis elegans 36,943 6-Jan-98

GB_BA1：CGU43535 2531 U43535 Corynebacterium glutamicum multidrug resistance protein (cmr) gene， Corynebacterium 36,658 9-Apr-97

complete cds. glutamicum

GB_RO：RNU30789 3510 U30789 Rattus norvegicus clone N27 mRNA. Rattus norvegicus 38,190 20-Aug-96rxa00295 1125 GB_BA2：CGU31281 1614 U31281 Corynebacterium glutamicum biotin synthase (bioB) gene，compiete cds. Corynebacterium 99,111 21-Nov-96

glutamicum

GB_BA1：BRLBIOBA 1647 D14084 Brevibacterium flavum gene for biotin synthetase，complete cds. Corynebacterium 98,489 3-Feb-99

glutanioum

GB_PAT：E03937 1005 E03937 DNA sequence encoding Brevibacterium flavum biotin-synthase. Corynebacterium 98,207 29-Sep-97

glutamicum rxa00323 1461 GB_BA1：MTCY427 38110 Z70692 Mycobacterium tuberculosis H37Rv complete genome；segment 99/162. Mycobacterium 35,615 24-Jun-99

tuberculosie

GB_BA1：MSGB32CS 36404 L78818 Mycobacterium leprae cosmid B32 DNA sequence. Mycobacterium leprae 60,917 15-Jun-96

GB_BA1：MTCY427 38110 Z70692 Mycobacterium tuberculosis H37Rv complete genome；segment 99/162. Mycobacterium 44,606 24-Jun-99

tuberculosisrxa00324 3258 GB_BA1：MSGB32CS 36404 L78818 Mycobacterium leprae cosmid B32 DNA sequence. Mycobacterium leprae 52,516 15-Jun-96

GB_BA1：MTCY427 38110 Z70692 Mycobacterium tuberculosis H37Rv complete genome；segment 99/162. Mycobacterium 38,079 24-Jun-99

tuberculosis

GB_OM：BOVELA 3242 J02717 Bovine elastin a mRNA，complete cds. Bos taurus 39,351 27-Apr-93rxa00330 1566 GB_BA1：CGTHRC 3120 X56037 Corynebacterium glutamicum thrC gene for threonine synthase (EC 4.2.99.2). Corynebacterium 99,808 17-Jun-97

glutamicum

GB_PAT：I09078 3146 109078 Sequence 4 from Patent WO 8809819. Unknown. 99,617 02-DEC-

1994

GB_BA1：BLTHRESY 1892 Z29563 Brevibacterium lactofenmentum；ATCC 13869∷DNA (genomic)；. Corynebacterium 99,170 20-Sep-95

N glutamicumrxa00335 1554 GB_BA1 ：CGGLNA 3686 Y13221 Corynebacterium glutamicum glnA gene. Corynebacterium 100,000 28-Aug-97

glutamicum

Table 4 (continuation)

GB_BA2：AF005635 1690 AF005635 Corynebacterium glutamicum glutamine synthetase (glnA) gene，complete Corynebacterium 98,906 14-Jun-99

cds. glutamicum

GB_BA1：MSGB27CS 38793 L78817 Mycobacterium leprae cosmid B27 DNA sequence. Mycobacterium leprae 66,345 15-Jun-96rxa00347 891 GB_EST27：AI455217 624 AI455217 LD21828.3prime LD Drosophila melanogaster embryo pOT2 Drosophila Drosophila melanogaster 34,510 09-MAR-

melanogaster cDNA clone LD21828 3prime，mRNA sequence. 1999

GB_BA2：SSU30252 2891 U30252 Synechococcus PCC7942 nucleoside diphosphate kinase and ORF2 protein Synechococcus PCC7942 37,084 29-OCT-

genes，complete cds，ORF1 protein gene，partial cds and neutral site I for 1999

vector use.

GB_EST21：AA911262 581 AA911262 oe75a02.s1 NCI_CGAP_Lu5 Homo sapiens cDNA clone IMAGE：1417418 3′ Homo sapiens 37,500 21-Apr-98

similar to gb；A18757 UROKINASE PLASMINOGEN ACTIVATOR SURFACE

RECEPTOR，GPI-ANCHORED (HUMAN)；，mRNA sequence. rxa00351 1578 GB_BA1：MLU15187 36138 U15187 Mycobacterium leprae cosmid L296. Mycobacterium leprae 52,972 09-MAR-

1995

GB_IN2：AC004373 72722 AC004373 Drosophila melanogaster DNA sequence (P1 DS05273 (D80))，complete Drosophila melanogaster 46,341 17-Jul-98

sequence.

GB_IN2：AF145653 3197 AF145653 Drosophila melanogester clone GH08860 BcDNA.GH08860 Drosophila melanogaster 49,471 14-Jun-99

(BcDNA.GH08860) mRNA，complete cds.rxa00365 727 GB_BA1：AB024708 8734 AB024708 Corynebacterium glutamicum gltB and gitD genes for glutamine 2- Corynebacterium 96,556 13-MAR-

oxoglutarate aminotransferase large and small subunits，complete cds. glutamicum 1999

GB_BA1：MTCY1A6 37751 Z83864 Mycobacterium tuberculosis H37Rv complete genome；segment 159/162. Mycobacterium 39,496 17-Jun-98

tuberculosis

GB_BA1：SC3A3 15901 AL109849 Streptomyces coelicolor cosmid 3A3. Streptomyces coelicolor 37,946 16-Aug-99

A3(2)rxa00366 480 GB_BA1：AB024708 8734 AB024708 Corynebacterium glutamicum gltB and gltD genes for glutamine 2- Corynebacterium 99,374 13-MAR-

oxoglutarate aminotransferase large and small subunits，complete cds. glutamicum 1999

GB_BA1：MTCY1A6 37751 Z83864 Mycobacterium tuberculosis H37Rv complete genome；segment 159/162. Mycobacterium 41,333 17-Jun-98

tuberculosis

GB_BA1：SC3A3 15901 AL109849 Streptomyces coelicolor cosmid 3A3. Streptomyces coelicolor 37,554 16-Aug-99

A3(2)rxa00367 4653 GB_BA1：AB024708 8734 AB024708 Corynebacterium glutamicum gltB and gltD genes for glutamine 2- Corynebacterium 99,312 13-MAR-

oxoglutarate aminotransferase large and small subunits，complete cds. glutamicum 1999

GB_BA1：MTCY1A6 37751 Z83864 Mycobacterium tuberculosis H37Rv complete genome；segment 159/162. Myoobacterium 36,971 17-Jun-98

tuberculosis

GB_BA1：SC3A3 15901 AL109849 Streptomyces coelicolor cosmid 3A3. Streptomyces coelicolor 37,905 16-Aug-99

A3(2)rxa00371 1917 GB_VI：SBVORFS 7568 M89923 Sugarcane bacilliform virus ORF 1，2，and 3 DNA，complete cds. Sugarcane bacilliform virus 35,843 12-Jun-93

GB_EST37：AI967505 380 AI967505 Ljirnpest03-215-c10 Ljirnp Lambda HybriZap two-hybrid library Lotus Lotus japonicus 42,593 24-Aug-99

japonicus cDNA clone LP215-03-c10 5′similar to 60S nibosomal protein L39，

mRNA sequence.

GB_IN1：CELK09H9 37881 AF043700 Ceenorhabditis elegans cosmid K09H9. Caenorhsbditis elegans 34,295 22-Jan-98

Table 4 (continuation) rxa 003771245 GB _ BA 1: CCU 136641678U 13664 Caulobacter creasertogens decarbonoylase homolog (hemE) Caulobacter creasertogens 36,83224-MAR-

gene，partial cds. 1995

GB_PL1：ANSDSGENE 1299 Y08866 A.nidulans sD gene. Emericella nidulans 39,603 17-OCT-

1996

GB_GSS4：AQ730303 483 AQ730303 HS_5505_B1_C04_T7A RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 36,728 15-Jul-99

genomic clone Plate＝1081 Col＝7 Row＝F，genomic survey sequence.rxa00382 1425 GB_BA1：PAHEML 4444 X82072 P.aeruginosa hemL gene. Pseudomonas aeruginosa 54,175 18-DEC-

1995

GB_BA1：MTY25D10 40838 Z95558 Mycobacterium tuberculosis H37Rv complete genome；segment 28/162. Mycobacterium 61,143 17-Jun-98

tuberculosis

GB_BA1：MSGY224 40051 AD000004 Mycobacterium tuberculosis sequence from clone y224. Mycobacterium 61,143 03-DEC-

tuberculosis 1996rxa00383 1467 GB_BA1：MLCB1222 34714 AL049491 Mycobacterium leprae cosmid B1222. Mycobacterium leprae 43,981 27-Aug-99

GB_HTG2：AC006269 167171 AC006269 Homo sapiens chromosome 17 clone hRPK.515_E_23 map 17，^***Homo sapiens 35,444 10-Jun-99

SEQUENCING IN PROGRESS^***，2 ordered pieces.

GB_HTG2：AC007638 178053 AC007638 Homo sapiens chromosome 17 clone hRPK.515_O_17 map 17，^***Homo sapiens 34,821 22-MAY-

SEQUENCING IN PROGRESS^***，8 unordered pieces. 1999rxa00391 843 GB_EST38：AW01705 613 AW017053 EST272398 Schistosoma marsoni male，Phil LoVerde/Joe Merrick Schistosoma mansoni 40,472 10-Sep-99

3 Schistosoma mansoni cDNA clone SMMAS14 5′end，mRNA sequence.

GB_PAT：AR065852 32207 AR065852 Sequence 20 from patent US 5849564. Unknown. 38,586 29-Sap-99

GB_Vt：AF148805 28559 AF148805 Kaposis sarcoma-associated herpesvirus ORF 68 gene，partial cds；and ORF Kaposis sarcoma- 38,509 2-Aug-99

69，kaposin，v-FLIP，v-cyclin，latent nuclear antigen，ORF K14，v-GPCR， associated herpesvirus

putative phosphoribosylformylglycinamidine synthase，and LAMP

(LAMP) genes，complete cds.rxa00393 1017 GB_BA1：MTY25D10 40838 Z95558 Mycobacterium tuberculosis H37Rv complete genome；segment 28/162. Mycobacterium 36,308 17-Jun-98

tuberculosis

GB_BA1：MSGY224 40051 AD000004 Mycobacterium tuberculosis sequence from clone y224. Mycobacterium 39,282 03-DEC-

tuberculosis 1996

GB_BA1：MLB1306 7762 Y13803 Mycobacterium leprae cosmid B1306 DNA. Mycobacterium leprae 39,228 24-Jun-97rxa00402 623 GB_BA2：AF052652 2096 AF052652 Corynebacterium glutamicum homoserine O-acetyltransferase(metA)gene， Corynebacterium 99,672 19-MAR-

complete cds. glutamicum 1998

GB_BA2：AF109162 4514 AF109162 Corynebacterium diphtheriae hame uptake locus，complete sequence. Corynebacterium 40,830 8-Jun-99

diphtheriae

GB_BA2：AF092918 20758 AF092918 Pseudomonas alcaligenes outer membrane Xcp-secretion system gene Pseudomonas alcaligenes 50,161 06-DEC-

cluster. 1998rxa00403 1254 GB_BA2：AF052652 2096 AF052652 Corynebacterium glutamicum homoserine O-acetyltransferase(metA)gene， Corynebacterium 99,920 19-MAR-

complete cds. glutamicum 1998

GB_BA1：MTV016 53662 AL021841 Mycobacterium tuberculosis H37Rv complete genome；segment 143/162. Mycobacterium 52,898 23-Jun-99

tuberculosis

GB_EST23：AI111288 750 AI111288 SWOvAMCAQ02A05SK Onchocerca volvulus adut male cDNA (SAW98MLW- Onchocerca volvulus 37,565 31-Aug-98

OvAM) Onchocerca volvulus cDNA clone SWOvAMCAQ02A05 5′，mRNA

sequence.

Table 4 (continuation) rxa 00405613 GB _ BA 1: MTV 01653662 AL021841 Mycobacterium tuberculosis H37Rv complete genome; segment 143/162 Mycobacterium 57,25923-Jun-99

tuberculosis

GB_PR4：AC005145 143678 AC005145 Homo sapiens Xp22-166-169 GSHB-523A23 (Genome Systems Human BAC Homo sapiens 34,179 08-DEC-

library) complete sequence. 1998

GB_BA1：MTV016 53662 AL021841 Mycobacterium tuberculosis H37Rv complete genome；segment 143/162. Mycobacterium 40,169 23-Jun-99

tuberculosisrxa00420 1587 GB_BA1：MTY13D12 37085 Z80343 Mycobacterium tuberculosis H37Rv complete genome；segment 156/162. Mycobacterium 62,031 17-Jun-98

tuberculosis

GB_BA1：MSGY126 37164 AD000012 Mycobacterium tuberculosis sequence from clone y126. Mycobacterium 61,902 10-DEC-

tuberculosis 1996

GB_BA1：MSGB971C 37566 L78821 Mycobacterium leprae cosmid B971 DNA sequence. Mycobacterium leprae 39,651 15-Jun-96

Srxa00435 1296 GB_BA1：AFACBBTZ2760 M68904 Alcaligenes eutrophus chromsomal transketolase.(cbbTc) and Ralstonia eutropha 38,677 27-Jul-94

phosphoglycolate phosphatase (cbbZc) genes，complete cds.

GB_HTG4：AC009541 169583 AC009541 Homo sapiens chromosome 7，^***SEQUENCING IN PROGRESS^***，25 Homo sapiens 36,335 12-OCT-

unordered pieces. 1999

GB_HTG4：AC009541 169583 AC009541 Homo sapiens chromosome 7，^***SEQUENCING IN PROGRESS^***，25 Homo sapiens 36,335 12-OCT-

unordered pieces. 1999rxa00437 579 GB_PR4：AC005951 155450 AC005951 Homo sapiens chromosome 17，clone hRPK.372_K_20，complete sequence. Homo sapiens 31,738 18-Nov-98

GB_BA1：SC2A11 22789 AL031184 Streptomyces coelicolor cosmid 2A11. Streptomyces coelicolor 43,262 5-Aug-98

GB_PR4：AC005951 155450 AC005951 Homo sapiens chromosome 17，clone hRPK.372_K_20，complete sequence. Homo sapiens 37,647 18-Nov-98rxa00439 591 GB_BA1：MTV016 53662 AL02t841 Mycobacterium tuberculosis H37Rv complete genome；segment 143/162. Mycobacterium 37,088 23-Jun-99

tuberculosis

GB_PL2：AF167358 1022 AF167358 Rumex acetosa expansin (EXP3) gene，partial ods. Rumex acetosa 46,538 17-Aug-99

GB_HTG3：AC009120 269445 AC009120 Homo sapiens chromosome 16 clone RPCI-11_484E3，^***SEQUENCING IN Homo sapiens 43,276 3-Aug-99

PROGRESS^***，34 unordered pieces.rxa00440 582 GB_BA2：SKZ86111 7860 Z86111 Streptomyces lividans rpsP，trmD，rplS，sipW，sipX，sipY，sipZ，mutT genes Streptomyces lividans 43,080 27-OCT-

and 4 open reading frames. 1999

GB_BA1：SC2E1 38962 AL023797 Streptomyces ccelicolor cosmid 2E1. Streptomyces coelicolor 42,931 4-Jun-98

GB_BA1：SC2E1 38962 AL023797 Streptomyces coelicolor cosmid 2E1. Streptomycos coelicolor 36,702 4-Jun-98rxa00441 1287 GB_PR2：HS173D1 117338 AL031984 Human DNA sequence from clone 173D1 on chromosome 1p36.21- Homo sapiens 38,027 23-Nov-99

36.33.Contains ESTs，STSs and GSSs，complete sequence.

GB_HTG2：HSDJ719K 267114 AL109931 Homo sapiens chrornosome X done RP4-719K3 map q21.1-21.31，^***Homo sapiens 34,521 03-DEC-

3 SEQUENCING IN PROGRESS^***，in unordered pieces. 1999

GB_HTG2：HSDJ719K 267114 AL109931 Homo sapiens chromosome X clone RP4-719K3 map q21.1-21.31，^***Homo sapiens 34,521 03-DEC-

3 SEQUENCING IN PROGRESS^***，in unordered pieces. 1999rxa00446 987 GB_BA1 ：SCD78 36224 AL034355 Streptomyces coelicolor cosmid D78. Streptomyces coelicolor 56,410 26-Nov-98

GB_HTG4：AC009367 226055 AC009367 Drosophila melanogaster chromosome 3L/76A2 clone RPC198-48B15，^***Drosophila melanogaster 34,959 16-OCT-

SEQUENCING IN PROGRESS^***，44 unordered pieces. 1999

GB_HTG4：AC009367 226055 AC009367 Drosophila melanogaster chromosome 3L/76A2 clone RPCI98-48B15，^***Drosophila melanogaster 34,959 16-OCT-

SEQUENCING IN PROGRESS^***，44 unordered pieces. 1999

Table 4 (continuation) rxa 004481143 GB _ PR 3: AC 00367088945 AC003670 Homo sapiens 12q13.1 PAC RPCI1-130F5(Roswell Park Cancer Institute Homo sapiens 35,6829-Jun-98

Human PAC library)complete sequence.

GB_HTG2：AF029367 148676 AF029367 Homo sapiens chromosome 12 clone RPCI-1 130F5 map 12q13.1，^***Homo sapiens 31,373 18-OCT-

SEQUENCING IN PROGRESS^***，156 unordered pieces. 1997

GB_HTG2：AF029367 148676 AF029367 Homo sapiens chromosome 12 clone RPCI-1 130F5 map 12q13.1，^***Homo sapiens 31,373 18-OCT-

SEQUENCING IN PROGRESS^***，156 unordered pieces. 1997rxa00450 424 GB_HTG2：AC007824 133361 AC007824 Drosophila melanogaster chromosome 3 clone BACR02L16 (D715) RPCI-98 Drosophila melanogaster 40,000 2-Aug-99

02.L.16 map 89E-90A strain y；cn bw sp，^***SEQUENCING IN PROGRESS

^***，91 unordered pieces.

GB_HTG2：AC007824 133361 AC007824 Drosophila melanogaster chromosome 3 clone BACR02L16 (D715) RPCI-98 Drosophila melanogaster 40,000 2-Aug-99

02.L.16 map 89E-90A strain y；cn bw sp，^***SEQUENCING IN PROGRESS

^***，91 unordered pieces.

GB_EST35：AI818057 412 AI818057 wk14a08.x1 NCI_CGAP_Lym12 Homo sapiens cDNA clone IMAGE：2412278 Homo sapiens 35,714 24-Aug-99

3′similar to gb：Y00764 UBIQUINOL-CYTOCHROME C REDUCTASE 11 KD

PROTEIN (HUMAN)；，mRNA sequence.rxa00461 975 GB_BA1：MLC81779 43254 Z98271 Mycobacterium leprae cosmid B1779. Mycobacterium leprae 39,308 8-Aug-97

GB_IN1：DMC86E4 29352 AL021086 Drosophila melanogastercosmid clone 86E4. Drosophila melanogaster 37,487 27-Apr-99

GB_GSS15：AQ64032 467 AQ640325 927P1-2H3.TP 927P1 Trypanosoma brucei genomic clone 927P1-2H3， Trypanosoma brucei 38,116 8-Jul-99

5 genomic survey sequence.rxa00465rxa00487 1692 GB_BA1：BAGUAA 3866 Y10499 B.ammoniagenes guaA gene. Corynebacterium 74,259 8-Jan-98

anmoniagenes

GB_BA2：U00015 42325 U00015 Mycobacterium leprae cosmid B1620. Mycobacterium leprae 37,248 01-MAR-

1994

GB_BA1：MTCY78 33818 Z77165 Mycobacterium tuberculosis H37Rv complete genome；segment 145/162. Mycobacterium 39,725 17-Jun-98

tuberculosisrxa00488 1641 GB_BA1：MTCY78 33818 Z77165 Mycobacterium tuberculosis H37Rv complete genome；segment 145/162. Mycobacterium 39,451 17-Jun-98

tuberculosis

GB_BA2：U00015 42325 U00015 Myccbacterium leprae cosmid B1620. Mycobacterium leprae 39,178 01MA R-

1994

GB_BA1：SCAJ10601 4692 AJ010601 Streptomyces coelicolor A3(2) DNA for whiD and whiK loci. Streptomyces coelicolor 60,835 17-Sep-o98rxa00489 1245 GB_BA2：U00015 42325 U00015 Mycubacterium leprae cosmid B1620. Mycobacterium leprae 38,041 01-MAR-

1994

GB_HTG2：HS225E12 126464 AL031772 Homo sapiens chromosome 6 clone RP1-225E12 map q24，^***Homo sapiens 36,756 03-DEC-

SEQUENCING IN PROGRESS^***，in unordered pieces. 1999

GB_HTG2：HS225Et2 126464 AL031772 Homo sapiens chromosome 6 clone RP1-225E12 map q24，^***Homo sapiens 36,756 03-DEC-

SEQUENCING IN PRESS^***，in unordered pieces. 1999rxa00533 1155 GB_BA1：CGLYS 2803 X57226 C.glutamicum lysC-alpha，lysC-beta and asd genes for aspartokinase-alpha Conynebacterium 99,913 17-Feb-97

and-beta subunits，and aspartate beta semialdehyde dehydrogenase， glutamicum

respectively (EC 2.7.2.4；EC 1.2.1.11).

Table 4 (continuation)

GB_BA1 ：CGCYSCAS 1591 X82928 C.glutamicum aspartate-semialdehyde dehydrogenase gene. Corynebacterium 99,221 17-Feb-97

D glutamicum

GB_PAT：A07546 2112 A07546 Recombinant DNA fragment (Pstl-Xhol). synthetic construct 99,391 30-Jul-93rxa00534 1386 GB_BA1：CGLYS 2803 X57226 C.glutamicum lysC-alpha，lysC-beta and asd genes for aspartokinase-alpha Corynebacterium 99,856 17-Feb-97

and -beta subunits，and aspartate beta semialdehyde dehydrogenase， glutamicum

respectively (EC 2.7.2.4；EC 1.2.1.11).

GB_BA1：CORASKD 2957 L16848 Corynebacterium fiavum aspartokinase (ask)，and aspartate-semialdehyde Corynebacterium 98,701 11-Jun-93

dehydrogenase (asd) genes，complete cds. ftavescens

GB_PAT：E14514 1643 E14514 DNA encoding Brevibacterium aspartokinase. Corynebacterlum 98,773 28-Jul-99

glutamicumrxa00536 1494 GB_BA1：CGLEUA 3492 X70959 C.glutamicum gene leuA for isopropylmalate synthase. Corynebecterium 100,000 10-Feb-99

giutamicum

GB_BA1：MTV025 121125 AL022121 Mycobacterium tubercuiosis H37Rv complete genome；segment 155/162. Mycobacterium 68,003 24-Jun-99

tuberculosis

GB_BA1：MTU88526 2412 U88526 Mycobacterium tuberculosis putative alpha-isopropyl malete synthase (leuA) Mycobactefium 68,185 26-Feb-97

gene，complete cds. tuberculosisrxa00537 2409 GB_BA2：SCD25 41622 AL118514 Streptomyces coelicolor cosmid D25. Streptomyces coelicolor 63,187 21-Sep-99

A3(2)

GB_BA1：MTCY7H7A 10451 Z95618 Mycobacterium tuberculosis H37Rv complete genome；segment 39/162. Mycobacterium 62,401 17-Jun-98

tuberculosis

GB_BA1：MTU34956 2462 U34956 Mycobacterium tuberculosis phosphoribosylformylglycinamidine synthase Mycobacterium 62,205 28-Jan-97

(purL) gene，complete cds. tuberculosisrxa00541 792 GB_PAT：I92052 2115 I92052 Sequence 19 from patent US 5726299. Unknown. 98,359 01-DEC-

1998

GB_BA1：MLCB5 38109 Z95151 Mycobacterium leprae cosmid B5. Mycobacterium leprae 62,468 24-Jun-97

GB_BA1：MTCY369 36850 Z80226 Mycobacterium tuberculosis H37Rv complete genome；segment 36/162. Mycobacterium 60,814 17-Jun-98

tuberculosisrxa00558 1470 GB_BA1：BAPURF 1885 X91252 B.ammoniagenes purF gene. Corynebacterium 66,095 5-Jun-97

ammoniagenes

GB_BA1：MLU15182 40123 U15182 Mycobacterium leprae cosmid B2266. Mycobacterium leprae 64,315 09-MAR-

1995

GB_BA1：MTCY7H7A 10451 Z95618 Mycobacterium tuberculosis H37Rv complete genome；segment 39/162. Mycobacterium 64,863 17-Jun-98

tuberculosisrxa00579 1983 GB_PAT：AR016483 2104 AR016483 Sequence 1 from patent US 5776740. Unknown. 98,810 05-DEC-

1998

EM_PAT：E11273 2104 E11273 DNA encoding serine hydroxymethyl transferase. Corynebacterium 98,810 08-OCT-

glutamicum 1997 (Rel.

52， Created)

GB_PAT：E12594 2104 E12594 DNA encoding serine hydroxymethyltransferase from Brevibacterium flavum. Corynebacterium 98,810 24-Jun-98

glutamicumrxa00580 1425 GB_PAT：E12594 2104 E12594 DNA encoding serine hydroxymethyltransferase from Brevibacterium flavum. Corynebacterium 99,368 24-Jun-98

glutamicum

Table 4 (continuation)

GB_PAT：AR016483 2104 AR016483 Sequence 1 from patent US 5776740. Unknown. 99,368 05-DEC-

1998

EM_PAT：E11273 2104 E11273 DNA encoding serine hydroxymethyl transferase. Corynebacterium 99,368 08-OCT-

glutamicum1997 (Rel.

52，Created)rxa00581 1092 GB_PAT：E12594 2104 E12594 DNA encoding serine hydroxymethyltransferase from Brevibacterium flavum. Corynebecterium 37,071 24-Jun-98

glutamicum

EM_PAT：E11273 2104 E11273 DNA encoding serine hydroxymethyl transferase. Corynebacterium 37,071 08-OCT-

glutamicum 1997 (Rel.

52，Created)

GB_PAT：AR016483 2104 AR016483 Sequence 1 from patent US 5776740. Unknown. 37,071 05-DEC-

1998rxa00584 1248 GB_BA1：CORAHPS 2570 L07603 Corynebacterium glutamicum 3-deoxy-D-arabinoheptulosonate-7-phosphate Corynebacterium 98,236 26-Apr-93

synthase gene，complete cds. glutamicum

GB_BA1：AOPCZA361 37941 AJ223998 Amycolatopsis orientalis cosmid PCZA361. Amycolatopsis orientalis 54,553 29-MAR-

1999

GB_BA1：D90714 14358 D90714 Escherichia coli genomic DNA. (16.8-17.1min). Escherichia coli 53,312 7-Feb-99rxa00618 1230 GB_EST19：AA802737 280 AA802737 GM06236.5prime GM Drosophila melanogaster ovary BlueScript Drosophila Drosophila melanogaster 39,928 25-Nov-98

melanogaster cDNA clone GM06236 5prime，mRNA sequence.

GB_EST28：AI534381 581 AI534381 SD07186.5prime SD Drosophila melanogaster Schneider L2 cell culture pOT2 Drosophila melanogaster 41,136 18-MAR-

Drosophita melanogaster cDNA clone SD07186 5prime similar to X89858：Ani 1999

FBgn0011558 PID：g927407 SPTREMBL：Q24240，mRNA sequence.

GB_IN1：DMANILLIN 4029 X89858 D.melanogaster mRNA for anillin protein. Drosophila melanogaster 34,398 8-Nov-95rxa00619 1551 GB_BA1：MTCY369 36850 Z80226 Mycobacterium tubercuiosis H37Rv complete genome；segment 36/162. Mycobacterium 62,776 17-Jun-98

tuberculosis

GB_BA1：MLCB5 38109 Z95151 Mycobacterium leprae cosmid B5. Mycobacterium leprae 61,831 24-Jun-97

GB_PAT：A60305 1845 A60305 Sequence 5 from Patent WO9708323. unidentified 61,785 06-MAR-

1998rxa00620 1014 GB_PL2：AF063247 1450 AF063247 Pneumocystis carinii f.ap.ratti enolase mRNA，complete cds. Pneumocystis carinii f.sp. 41,060 5-Jan-99

ratti

GB_BA1：STMAPP 2069 M91546 Streptomyces lividans aminopeptidase P (PepP) gene，comptete cds. Streptomyces lividans 37,126 12-Jun-93

GB_HTG3：AC008763 214575 AC008763 Homo sapiens chromosome 19 clone CITB-E1_3214H19，^***SEQUENCING Homo sapiens 40,020 3-Aug-99

IN PROGRESS^***，21 unordered pieces.rxa00624 810 GB_IN1：CEY41E3 150641 Z95559 Caenorhabditis elegans cosmid Y41E3，complete sequence. Caenorhabditis elegans 36,986 2-Sep-99

GB_EST13AA362167 372 AA362167 EST71561 Macrophage I Homo sapiens cDNA 5′end，mRNA sequence. Homo sapiens 38,378 21-Apr-97

GB_IN1：CEY41E3 150641 Z95559 Caenorhabditis elegans cosmid Y41E3，complete sequence. Caenorhabditis elegans 37,694 2-Sep-99rxa00626 1386 GB_BA1 ：MTCY369 36850 Z80226 Mycobacterium tuberculosis H37Rv complete genome；segment 36/162. Mycobacterium 57,971 17-Jun-98

tuberculosis

GB_BA1：MLCB5 36109 Z95151 Mycobacterium leprae cosmid B5. Mycobacterium leprae 58,806 24-Jun-97

GB_BA1：MLU15187 36138 U15187 Mycobacterium leprae cosmid L296. Mycobacterium leprae 38,007 09-MAR-

1995

Table 4 (continuation) rxa 00632795 GB _ BA 1: BrLBIOAD 2272D 14083 Brevibacterium flavum genes for 7, 8-diaminoperlotinic acid aminotransferase Corynebacterium 97,3583-Feb-99

and dethiobiotin synthetase，complete cds. glutamicum

GB_PAT：E04041 675 E04041 DNA sequence coding for desthiobiotinsynthetase. Corynebacterium 98,074 29-Sep-97

glutamicum

GB_PAT：E04040 1272 E04040 DNA sequence coding for diamino pelargonic acid aminotransferase. Corynebacterium 93,814 29-Sep-97

glutamicumrxa00633 1392 GB_BA1：BRLBIOAD 2272 D14083 Brevibacterium flavum genes for 7，8-diaminopelargonic acid aminotransferase Corynebacterium 95,690 3-Feb-99

and dethiobiotin synthetase，complete cds. glutamicum

GB_PAT：E04040 1272 E04040 DNA sequence coding for diamino pelarcgonic acid aminotransferase. Corynebacterium 95,755 29-Sep-97

glutamicum

GB_BA2：EHU38519 1290 U38519 Erwinia herbicola adenosylmethionine-8-amino-7-oxononanoate transaminase Enwinia herbicola 55,564 4-Nov-96

(bioA) gene，complete cds.rxa00688 666 GB_BA1：MTV041 28826 AL021958 Mycobacterium tuberculosis H37Rv complete genome；segment 35/162. Mycobacterium 60,030 17-Jun-98

tuberculosis

GB_BA1：BRLSECY 1516 D14162 Brevibacterium flavum gene for SecY protein (complete cds) and gene or Corynebacterium 99,563 3-Feb-99

adenylate kinase (partial cds). glutamicum

GB_BA2：MBU77912 7163 U77912 Mycobacterium bovis MBE50a gene，partial cds；and MBE50b，MBE50c， Mycobacterium bovis 60,030 27-Jan-99

preprotein translocase SecY subunit (secY)，adenylate kinase (adk)，

methionine aminopeptidase (map)，RNA polymerase ECF sigma factor

(sigE50)，MBE50d，and MBE50e genes，complete cds.rxa00708 930 GB_BA2：AF157493 25454 AF157493 Zymomonas mobilis ZM4 fosmid clone 42D7，complete sequence. Zymomonas mobilis 39,116 5-Jul-99

GB_PAT：I00836 1853 I00836 Sequence 1 from Patent US 4758514. Unknown. 47,419 21-MAY-

1993

GB_PAT：E00311 1853 E00311 DNA coding of 2，5-diketogluconic acid reductase unidentified 47,419 29-Sep-97rxa00717 1083 GB_PAT：I78753 1187 I78753 Sequence 9 from patent US 5693781. Unknown. 37,814 3-Apr-98

GB_PAT：I92042 1187 I92042 Sequence 9 from patent US 5726299. Unknown. 37,814 01-DEC-

1996

GB_BA1：MTCI125 37432 Z98268 Mycobacterium tuberculosis H37Rv complete genome；segment 76/162. Mycobacterium 50,647 17-Jun-98

tuberculosisrxa00718 831 GB_BA1：MTCI125 37432 Z98268 Mycobacterium tuberculosis H37Rv complete genome；segment 76/162. Mycobacterium 55,228 17-Jun-98

tuberculosis

GB_BA1：MTCI125 37432 Z98268 Mycobacterium tuberculosis H37Rv complete genome；segment 76/162. Mycobacterium 40,300 17-Jun-98

tuberculosis

GB_GSS12：AQ42075 671 AQ420755 RPCI-11-168G18.TJ RPCI-11 Homo sapiens genomic clone RPCI-11- Homo sapiens 35,750 23-MAR-

5 168G18，genomic survey sequence. 1999rxa007271035 GB_HTG3：AC008332 118545 AC008332 Drosophila melanogaster chromosome 2 clone BACR48D10 (D867) RPCI-98 Drosophila melanogaster 40,634 6-Aug-99

48.D.10 map 34A-34A strain y；cn bw sp，^***SEQUENCING IN PROGRESS

^***，78 unordered pieces.

GB_HTG3：AC008332 118545 AC008332 Drosophila melanogaster chromosome 2 clone BACR48D10 (D867) RPCl-98 Drosophila melanogaster 40,634 6-Aug-99

48.D.10 map 34A-34A strain y；cn bw sp，^***SEQUENCING IN

PROGRESS^***，78 unordered pieces.

Table 4 (continuation)

GB_HTG3：AC008332 118545 AC008332 Drosophila melanogaster chromosome 2 clone BACR48D10 (D867) RPC1-98 Drosophila melanogaster 33,888 6-Aug-99

48.D.10 map 34A-34A strain y；cn bw sp，^***SEQUENCING IN

PROGRESS^***，78 unordered pieces.rxa00766 966 GB_HTG2：AC006789 83823 AC006789 Caenorhabditis elegans clone Y49F6，^***SEQUENCING IN PROGRESS^***， Caenorhabditis elegans 36,737 25-Feb-99

2 unordered pieces.

GB_HTG2：AC006789 83823 AC006789 Caenorhabditis elegansclone Y49F6，^***SEQUENCING IN PROGRESS^***， Caenorhabditis elegans 36,737 25-Feb-99

2 unordered pieces.

GB_BA1：D90810 20476 D90810 E.coli genomic DNA，Kohara clone #319(37.4-37.8min.). Escherichia coli 36,526 29-MAY-

1997rxa00770 1293 GB_BA1：MTV043 68848 AL022004 Mycobacterium tuberculosis H37Rv complete genome；segment 40/162. Mycobacterium 66,193 24-Jun-99

tuberculosis

GB_BA1：MLU15182 40123 U15182 Mycobacterium leprae cosmid B2266. Mycobacterium leprae 61,443 09-MAR-

1995

GB_BA2：SCD25 41622 AL118514 Streptomyces coelicolor cosmid D25. Streptomyces coelicolot 59,938 21-Sep-99

A3(2)rxa00779 1056 GB_HTG1：CER08A5 51920 282281 Caenorhabditis elegans chromosome V clone R08A5，^***SEQUENCING INCaenorhabditis elegans 64,896 14-OCT-

PROGRESS^***，in unordered pieces. 1998

GB_HTG1；CER08A5 51920 782281 Caenorhabditis elegans chromosome V clone R08A5，^***SEQUENCING IN Caenorhabditis elegans 64,896 14-OCT-

PROGRESS^***，in unordered pieces. 1998

GB_PI2：AF078693 1492 AF078693 Chlamydomonas reinhardtii putative O-acetylserine(thiol)lyase precursor Chlamydomonas reinhardtii 57,970 3-Nov-99

(Crcys-1A) mRNA，nuclear gene encoding organellar protein，complete cds.rxa00780 669 GB_BA1：MTCY98 31225 Z83860 Mycobacterium tuberculosis H37Rv complete genome；segment 103/162. Mycobacterium 54,410 17-Jun-98

tuberculosis

GB_BA1：AVINIFREG 7099 M60090 Azotobacter chroococcum nifU，nifS，nifV，nifP，nifW，nifZ and nifM genes， Azotobacter chroococcum 51,729 26-Apr-93

complete cds.

GB_BA2：AF001780 6701 AF001780 Cyanothece PCC 8801 NifP (nifP)，nitrogenase (nirB)，FdxN (fdxN)，NitS (nifS) Cyanothece PCC880136,309 08-MAR-

and NifU(nifU) genes，complete cds，and NifH (nifH) gene，partial cds. 1999rxa00838 1023 GB_EST1：Z30506 329 Z30506 ATTS2430 AC16H Arabidopsis thaliana cDNA clone TAI306 3′，mRNA Arabidopsis thaliana 44,308 11-MAR-

sequence. 1994

GB_PL2：AC006258 110469 AC006258 Arabidopsis thaliana BAC F18G18 from chromosome V near 60.5 cM， Arabidopsis thaliana 35,571 28-DEC-

complete sequence. 1998

GB_EST37：AI998439 455 AI998439 701545695 A.thaliana，Columbia Col-0，rosette-2 Arabidopsis thaliana cDNA Arabidopsis thaliana 36,044 8-Sep-99

clone 701545695，mRNA sequence.rxa00863 867 GB_BA1：BLDAPAB 3572 Z21502 B.lactofermentum dapA and dapB genes for dinydrodipicolinate synthase and Corynebacterium 99,539 16-Aug-93

dihydrodipicolinate reductase glutamicum

GB_PAT：E16749 2001 E16749 gDNA encoding dihydrodipicolinate synthase (DDPS). Corynebacterium 99,539 28-Jul-99

glutamicum

GB_PAT：E14520 2001 E14520 DNA encoding Brevibacterium dihydrodipicolinic acid synthase. Corynebacterium 99,539 28-Jul-99

glutamicumrxa00864 873 GB_BA1：BLDAPAB 3572 Z21502 B.lactofermentum dapA and dapB genes for dihydrodipicolinate synthase and Corynebacterium 99,885 16-Aug-93

dihydrodipicolinate reductase. glutamicum

GB_BA1：CGDAPB 1902 X67737 C.glutamicum dapB gene for dihydrodipicolinate reductase. Corynebacterium 100,000 1-Apr-93

glutamicum

Table 4 (continuation)

GB_PAT：E14520 2001 E14520 DNA encoding Brevibacterium dihydrodipicolinic acid synthase. Corynebacterium 100,000 28-Jul-99

glutamicumrxa00865 1026 GB_BA1：BLDAPAB 3572 Z21502 B.lactofermentum dapA and dapB genes for dihydrodipicolinate synthase and Corynebacterium 100,000 16-Aug-93

dihydrodipicolinate reductase. glutamicum

GB_PAT：E16752 1411 E16752 gDNA encoding dihydrodipicolinate reductase (DDPR). Corynebacterium 99,805 28-Jul-99

glutamicum

GB_PAT：AR038113 1411 AR038113 Sequence 18 from patent US 5804414. Unknown. 99,805 29-Sep-99rxa00867 650 GB_BA1：MTV002 56414 AL008967 Mycobacterium tuberculosis H37Rv complete genome；segment 122/162. Mycobacterium 39,179 17-Jun-g8

tuberculosis

GB_BA1：MLCB22 40281 Z98741 Mycobacterium leprae cosmid B22. Mycobacterium leprae 39,482 22-Aug-97

GB_BA1：SAU19858 2838 U19858 Streptomyces antibioticus guanosine pentaphosphate synthetase (gpsl) gene， Streptomyces antibioticus 69,706 25-OCT-

comptete cds. 1996rxa00873 779 GB_BA1：SCO001206 9184 AJ001206 Streptomyces coelicolor A3(2)，glycogen metabolism cluster II. Streptomyces coelicoior 63,415 29-MAR-

1999

GB_BA1：SCO001205 9589 AJ001205 Streptomyces coelicolor A3(2) glycogen metabolism clusterl. Streptomyces coelicoior 61,617 29-MAR-

1999

GB_BA1：D78198 2304 D78198 Pimelobacter sp. DNA for trehalose synthase，complete cds. Pimelobacter sp. 60,594 5-Feb-99rxa00884 1263 GB_BA1：MTCY253 41230 Z81368 Mycobacterium tuberculosis H37Rv complete genome；segment 106/162. Mycobacterium 37,785 17-Jun-98

tuberculosis

GB_BA1：MSGY222 41156 AD000010 Mycobacterium tuberculosis sequence from clone y222. Mycobacterium 38,006 03-DEC-

tuberculosis 1996

GB_GSS15：AQ65460 468 AQ654600 Sheered DNA-1O14.TF Sheared DNA Trypanosorna brucei genomic clone Trypanosoma brucei 33,974 22-Jun-99

0 Sheared DNA-1O14，genomic survey sequence.rxaO0891 1102 GB_BA1：MTCI418B 11700 Z96071 Mycobacterium tuberculosis H37Rv complete genome；segment 7/162. Mycobacterium 63,297 18-Jun-98

tuberculosis

GB_BA1：SCO001206 9184 AJ001206 Streptomyces coelicolor A3(2)，glycogen metabolism duster II. Streptomyces coelicolor 61,965 29-MAR-

1999

GB_BA1：SCO001205 9589 AJ001205 Streptomyces coelicolor A3(2) glycogen metabolism clustarl. Streptomyces coelicolor 61,727 29-MAR-

1999rxa00952 963 EM_PAT：E10963 3118 E10963 gDNA encoding tryptophan synthase. Corynebacterium 99,688 08-OCT-

glutamicum 1997 (Rel.

52，Created)

GB_BA1：BLTRP 7725 X04960 Brevibacterium lactofermentum tryptophan operon. Corynebacterium 98,847 10-Feb-99

glutamicum

GB_PAT：E01688 7725 E01588 Cenomic DNA of trp operon of prepibacterium latophelmentamn. unidentified 98,428 29-Sep-97rxa00954 644 GB_PAT：E01375 7726 E01375 DNA sequence of tryptophan operon. Corynebacterium 98,758 29-Sep-97

glutamicum

GB_PAT：E01688 7725 E01688 Genornic DNA of trp operon of prepibacterium latophelmentamn. unidentifted 98,758 29-Sep-97

GB_BA1：BLTRP 7725 X04960 Brevibacterium lactofermentum tryptophan operon. Corynebacterium 98,758 10-Feb-99

glutamicumrxa00955 1545 GB_PAT：E01375 7726 E01375 DNA sequence of tryptophan operon. Corynebacterium 98,372 29-Sep-97

glutamicum

Table 4 (continuation)

GB_BA1：BLTRP 7725 X04960 Brevibacterium lactofermentum tryptophan operon. Corynebacterium 98,372 10-Feb-99

glutamicum

GB_PAT：E01688 7725 E01688 Genomic DNA of trp operon of prepibacterium latophelmentamn. unidentified 98,242 29-Sep-97rxa00956 1237 EM_PAT：E10963 3118 E10963 gDNA encoding tryptophan synthase. Corynebactedum 98,949 08-OCT-

glulamicum 1997 (Rol.

52，Created)

GB_BA1：BLTRP 7725 X04960 Brevibacterium lactofermentum tryptophan operon. Corynebacterium 99,107 10-Feb-99

glutamicum

GB_PAT：E01375 7726 E01375 DNA sequence of tryptophan operon. Corynebacterium 98,945 29-Sep-97

glutamlcumrxa00957 1677 GB_BA1：BLTRP 7725 X04960 Brevibacterium lactofemientum tryptophan operon. Corynebacterium 99,165 10-Feb-99

glutamicum

GB_PAT：E01375 7726 E01375 DNA sequence of tryptophan operon. Cotynebacterium 98,927 29-Sep-97

glutamicom

GB_PAT：E01688 7725 E01688 Genomic DNA of trp operon of prepibacterium tatophelmentamn. unidentified 98,867 29-Sep-97rxa00958 747 GB_BA1：BLTRP 7725 X04960 Brevibacterium lactofermentum tryptophan operon. Corynebacterium 98,792 10-Feb-99

glutamicum

GB_PAT：E01375 7726 E01375 DNA sequence of tryptophan operon. Corynebacterium 98,792 29-Sep-97

glutamicum

GB_PAT：E01688 7725 E01688 Genomic DNA of trp operon of prepibacterium latophelmentamn. unidentifiad 98,658 29-Sep-97rxa00970 1050 GB_BA1：CGHOMTHR 3685 Y00546 Corynebacterium glutamicum hom-thrB genes for homoserine dehydrogenase Conynebacterium 99,905 12-Sep-93

and homoserice kinase. glutamicum

GB_PAT：I09077 3685 109077 Sequence 1 from Patent WO 8809819. Unknown. 99,810 02-DEC-

1994

GB_PAT：E01358 2615 E01358 DNA encoding for homoserine dehydrogenase(HDH)and homoserine Corynebacterium 97,524 29-Sep-97

kinase(HK). glulamicumrxa00972 1458 GB_PAT：E16755 3579 E16755 gDNA encoding diaminopimelate decarboxylase (DDC) and arginyl-tRNA Corynebacterium 99,931 28-Jul-99

synthase. glutamicum

GB_PAT：AR038110 3579 AR038110 Sequence 15 from patent US 5804414. Unknown. 99,931 29-Sep-99

GB_PAT：E14508 3579 E14508 DNA encoding Brevibacterium diaminopimelic acid decarboxylase and arginyl- Corynebacterium 99,931 28-Jul-99

tRNA synthase. glutamicumrxa00981 753 GB_OV：GGA245664 512AJ245664 Gallus gallus partial mRNA for ATP-citrate lyase (ACL gene). Gallus gallus 37,538 28-Sep-99

GB_PL2：AC007887 159434 AC007887 Genomic sequence for Arabidopsis thaliana BAC F15O4 from chromosome I， Arabidopsis thaliana 37,600 04-OCT-

complete sequence. 1999

GB_GSS1：CNS00RN 542 AL087338 Arabidopsis thaliana genome survey sequence T7 end of BAC F14D7 of IGF Arabidopsis thaliana 41,264 28-Jun-99

W library from strain Columbia of Arabidopsis thaliana，genomic survey

sequence.rxa00989 1644 GB_BA1：MTV008 63033 AL021246 Mycobacterium tuberculosis H37Rv complete genome；segment 108/162. Mycobacterium 40,773 17-Jun-98

tuberculosis

GB_BA1：SCVALSFP 3619 Y13070 S.coelicolor valS，fpgs，ndk genes. Streptomyces coelicolor 58,119 03-MAR-

1998

GB_BA1：MTV008 63033 AL021246 Mycobacterium tuberculosis H37Rv complete genome；segment 108/162. Mycobacterium 38,167 17-Jun-98

tuberculosis

Table 4 (continuation) rxa 00997705 GB _ BA 2: CGU 312251817U 31225 Corynebacterium glutamicum L-proline: NADP + 5-oxoglucase (proC) gene, Corynebacterium 40,8412-Aug-96

complete cds. glutamicum

GB_HTG1：CEY39C12 282838 AL009026 Caenorhabditis elegans chromosome IV clone Y39C12，^***SEQUENCING IN Caenorhabditis elegans 36,416 26-OCT-

PROGRESS^***，in unordered pieces. 1999

GB_IN1 ：CEB0001 39416 Z69634 Caenorhabditis elegans cosmid B0001，complete sequence. Caenorhabditis elegans 36,416 2-Sep-99rxa01019 1110 GB_HTG2：AC005052 144734 AC005052 Homo sapiens clone RG038K21，^***SEQUENCING IN PROGRESS^***，3 Homo sapiens 39,172 12-Jun-98

unordered pieces.

GB_HTG2：AC005052 144734 AC005052 Homo sapiens clone RG038K21，^***SEQUENCING IN PROGRESS^***，3 Homo sapiens 39,172 12-Jun-98

unodered pieces.

GB_GSS9：AQ171808 512AQ171808 HS_3179_A1_G03_T7 CIT Approved Human Genomic Sperm Library D Homo sapiens 34,661 17-OCT-

Homo sapiens genomic clone Ptate＝3179 Col＝5 Row＝M，genomic survey 1998

sequence.rxa01026 1782 GB_BA1：SC1C2 42210 AL031124 Streplomycescoelicolorcosmid 1C2. Streptomyces ccelicolor 68,275 15-Jan-99

GB_BA1：ATLEUCD 2982 X84647 A.teichomyceticus teuC and leuD genes. Actinoplanes 65,935 04-OCT-

teichomyceticus 1995

GB_BA1：MTV012 70287 AL021287 Mycobacterium tuberculosis H37Rv complete genome；segment 132/162. Mycobacterium 40,454 23-Jun-99

tuberculosisrxa01027 1131 GB_BA1：MLCB637 44882 Z99263 Mycobacterium leprae cosmid B637. Mycobacterium leprae 38,636 17-Sep-97

GB_BA1：MTCY349 43523 Z83018 Mycobacterium tuberculosis H37Rv complete genome；segment 131/162. Mycobacterium 51,989 17-Jun-98

tuberculosis

GB_BA1：SPUNGMUT 1172 Z21702 S.pneumoniae ung gene and mutX genes encoding uracil-DNA glycosylase Streptococcus pneumoniae 38,088 15-Jun-94

X and 8-oxodGTP nucieoside triphosphatase.rxa01073 954 GB_BA1：BACOUTB 1004 M15811 Bacillus subtilis outB gene encoding a sporulation protein，complete cds. Bacillus subtilis 53,723 26-Apr-93

GB_PR4：AC007938 167237 AC007938 Homo sapiens clone UWGC：djs201 from 7q31，comptete sequence. Homo sapiens 34,322 1-Jul-99

GB_PL2：ATAC006282 92577 AC006282 Arabidopsis thaliana chromosome II BAC F13K3 genomic sequence， Arabidopsis thaliana 36,181 13-MAR-

complete sequence. 1999rxa01079 2226 GB_BA2：AF112535 4363 AF112535 Corynebacterium glutamicum putative glutaredoxin NrdH (nrdH)，NrdI (nrdI)， Corynebacterium 99,820 5-Aug-99

and ribonucleotide reductase alpha-chain (nrdE) genes，comptete cds. glutamicum

GB_BA1：CANRDFGE 6054 Y09572 Corynebacterium ammoniagenes nrdH，nrdI，nrdE，nrdF genes. Corynebacterium 75,966 18-Apr-98

Nammoniagenes

GB_BA1：MTV012 70287 AL021287 Mycobacterium tuberculosis H37Rv complete genome；segment 132/162. Mycobacterium 38,296 23-Jun-99

tuberculosisrxa01080 567 GB_BA2：AF112535 4363 AF112535 Corynebacterium glutamicum putative glutaredoxin NrdH (nrdH)，NrdI (nrdt)， Corynebacteriun 100,000 5-Aug-99

and ribonucleotide reductase alpha-chain (nrdE) genes，complete cds. glutamicum

GB_BA1：CANRDFGE 6054 Y09572 Corynebacterium ammoniagenes nrdH，nrdI，nrdE，nrdF genes. Corynebacteriurn 65,511 18-Apr-98

N ammoniagenes

GB_BA1：STNRD 4894 X73226 S.typhimurium nrdEF operon. Salmonella typhimurium 52,477 03-MAR-

1997rxa01087 999 GB_IN2：AF063412 1093 AF063412 Limnadia lenticularis elongation factor 1-alpha mRNA，partial cds. Limnadia lenticularis 43,750 29-MAR-

1999

GB_PR3：HS24M15 134539 794055 Human DNA sequence from PAC 24M15 on chromosome 1，Contains Homo sapiens 37,475 23-Nov-99

tenascin-R (restrictin)，EST.

GB_IN2：ARU85702 1240 U85702 Anathix ralla elongation factor-1 alpha (EF-1a) gene，partial cds. Anathix ralta 37,319 16-Jul-97

Table 4 (continuation) rxa 01095857 GB _ BA 1: MTCY01B 235938Z 95554 Mycobacterium tuberculosis H37Rv complete genome; segment72/162 Mycobacterium 43,24317-Jun-98

tuberculosis

GB_HTG5：AC011632 175917 AC011632 Homo sapiens clone RP11-3N13，WORKING DRAFT SEQUENCE，9 Homo sapiens 36,471 19-Nov-99

unordlered pieces.

GB_HTG5：AC011632 175917 AC011632 Homo sapiens clone RP11-3N13，WORKING DRAFT SEQUENCE，9 Homo sapiens 36,836 19-Nov-99

unordered pieces.rxa01097 477 GB_BA2：AF030405 774 AF030405 Corynebacterium glutamicum cyclase (hisF) gene，complete cds. Corynebacterium 100,000 13-Nov-97

glutamicum

GB_BA2：AF030405 774 AF030405 Corynebacterium glutamicum cyclase (hisF) gene，complete cds. Corynebacterium 41,206 13-Nov-97

glutamicumrxa01098 897 GB_BA2：AF030405 774 AF030405 Corynebacterium glutamicum cyclase (hisF) gene，complete cds. Corynebacterium 97,933 13-Nov-97

glutamicum

GB_BA1：MSGY223 42061 AD000019 Mycobacterium tuberculosis sequence from clone y223. Mycobacterium 40,972 10-DEC-

tuberculosis 1996

GB_BA1：MLCB1610 40055 AL049913 Myeobacterium ieprae cosmid B1610. Mycobacterium leprae 61,366 27-Aug-99rxa01100 861 GB_BA2：AF051846 738 AF051846 Corynebacterium glutamicum phosphoribosylformimino-5-amino-1- Corynebacterium 97,154 12-MAR-

phosphoribosyt-4-imidazotecarboxamide isomerase (hisA) gene， glutamicum 1998

complete cds.

GB_BA2：AF060558 636 AF060558 Corynebacterium glutamicum glutamine amidotransferase (hisH) gene， Corynebacterium 95,455 29-Apr-98

complete cdls. glutamicum

GB_HTG1：HSDJ140A 221755 AL109917 Homo sapiens chromosome 1 clone RP1-140A9，^***SEQUENCING IN Homo sapiens 30,523 23-Nov-99

9 PROGRESS^***，in unordered pieces.rxa01101 756 GB_BA2：AF060558 636 AF060558 Corynebacterium glutamicum glutamine amidotransferase(hisH)gene， Corynebacterium 94,462 29-Apr-98

complete cds. giutamicum

GB_BA1：SC4G6 36917 AL096884 Streptomyces coelicolor cosmid 4G6. Streptomyces coelicolor 38,378 23-Jul-99

A3(2)

GB_BA1：STMHISOPA 3981 M31628 S.coellicolor histidine biosynthesis operon encoding hisD，partial cds.，and Streptomyces cnelicolor 60,053 26-Apr-93

hisC，hisB，hieH，and hisA genes，complete cds.rxa01104 729 GB_BA1：STMHISOPA 3981 M31628 S.coelicolor histidtine biosynthesis operon encoding hisD，partial cds.，and Streptomyces coelicolor 58,333 26-Apr-93

hisC，hisB，hisH，and hisA genes，complete cds.

GB_BA1：SC4G6 36917 AL096884 Streptomyces coelicolor cosmid 4G6. Streptomyces coelicolor 39,045 23-Jul-99

A3(2)

GB_BA1：MTCY336 32437 Z95586 Mycobacterium tuberculosis H37Rv complete genome；segment 70/162. Mycobacterium 60,364 24-Jun-99

tuberculosisrxa01105 1221 GB_BA1：MTCY336 32437 Z95586 Mycobacterium tuberculosis H37Rv complete genorne；segment 70/162. Mycobacterium 60,931 24-Jun-99

tuberculosis

GB_BA1：MSGY223 42061 AD000019 Mycobacterium tuberculosis sequence trom clone y223. Mycobacterium 36,851 10-DEC-

tuberculosis 1996

GB_BA1：MLCB1610 40055 AL049913 Mycobacterium leprae cosmid B1610. Mycobacterium leprae 60,902 27-Aug-99rxa01106 1449 GB_BA1：MSGY223 42061 AD000019 Mycobacterium tuberculosis sequence from clone y223. Mycobacterium 37,233 10-DEC

tuberculosis 1996

Table 4 (continuation)

GB_BA1：MSHISCD 2298 X65542 M.smegmatis genes hisD and hisC for histidinol dehydrogenase and histidinol- Mycobacterium smegmatis 60,111 30-Jun-93

phosphate aminotransferase，respectively.

GB_BA1：MTCY336 32437 Z95586 Mycobacterium tuberculosis H37Rv complete genome；segment 70/162. Mycobacterium 58,420 24-Jun-99

tuberculosisrxa01145 1137 GB_BA1：CORAIA 4705 L09232 Corynebacterium glutamicum acetohydroxy acid synthase (ilvB) and (ilvN) Corynebacterium 100,000 23-Feb-95

genes，and acetohydroxy acid isomeroreductase (ilvC) gene，complete cds. glutamicum

GB_BA1：BRULVCA 1364 D14551 Brevibacterium flavum ilvC gene for acetohydroxy acid isomeroreductase， Corynebacterium 99,560 3-Feb-99

complete cds. glutamicum

GB_PAT：E08232 1017 E08232 DNA encoding acetohydroxy-acid isomerordeductase. Corynebacterium 99,803 29-Sep-97

glutamicumrxa01162 1449 GB_PAT：A60299 2869 A60299 Sequence 18 from Patent WO9706261. Aspergillus niger 38,675 06-MAR-

1998

GB_PR3：HS24E5 35506 Z82185 Human DNA sequence from Fosmid 24E5 on chromosome 22q11.2-qter Homo sapiens 36,204 23-Nov-99

contains parvalbumin，ESTs，STS.

GB_PR3：AC005265 43900 AC005265 Homo sapiens chromosome 19，cosmid F19750，complete sequence. Homo sapiens 38,363 6-Jul-98rxa01208 846 GB_HTG2：AC004965 323792 AC004965 Homo sapiens clone DJ1106H14，^***SEQUENCING IN PROGRESS^***，42 Homo sapiens 36,058 12-Jun-98

unordered pieces.

GB_HTG2：AC004965 323792 AC004965 Homo sapiens clone DJ1106H14，^***SEQUENCING IN PROGRESS^***，42 Homo sapiens 36,058 12-Jun-98

unorderecd pieces.

GB_PL2：TAUS5859 2397 U55859 Triticum aestivum heat shock protein 80 mRNA，complete cds. Triticum aestivum 37,269 1-Feb-99rxa01209 1528 GB_HTG3：AC011469 113436 AC011469 Homo sapiens chromosome 19 clone CIT-HSPC_475D23，^***SEQUENCING Homo sapiens 40,000 07-OCT-

IN PROGRESS^***，31 unordered pieces. 1999

GB_HTG3：AC011469 113436 AC011469 Homo sapiens chromosome 19 clone CIT-HSPC_475D23，^***SEQUENCING Homo sapiens 40,000 07-OCT-

IN PROGRESS^***，31 unordered pieces. 1999

GB_PL1：AB010077 77380 AB010077 Arabidopsis thaliana genomic DNA，chromosome 5，P1 clone：MYH19， Arabidopsis thaliana 36,803 20-Nov-99

complete sequence.rxa01215 1098 GB_BA1：MTCY10G2 38970 Z92539 Mycobacterium tuberculosis H37Rv complete genome；segment 47/162. Mycobacterium 37,047 17-Jun-98

tuberculosis

GB_IN1：LEIPRPP 1887 M76553 Leishmania donovani phosphoribosylpyrophosphate synthetase gene， Leishmania donovani 50,738 7-Jun-93

complete cds.

GB_HTG2：HSJ799D1 130149 AL050344 Homo sapiens chromosome 1 clone RP4-799D16 map p34.3-36.1，^***Homo sapiens 38,135 29-Nov-99

6 SEQUENCING IN PROGRESS^***，in unordered pieces.rxa01239 2556 GB_BA1：MTCY48 35377 Z74020 Mycobacterium tuberculosis H37Rv complete genome；segment 69/162. Mycobacterium 38,139 17-Jun-98

tuberculosis

GB_PR2：AB029032 6377 AB029032 Homo sapiens mRNA for KIAA1109 protein，partial cds. Homo sapiens 39,394 4-Aug-99

GB_GSS9：AQ107201 355 AQ107201 HS_3098_A1_C03_T7 CIT Approved Human Genomic Sperrn Library D Homo sapiens 41,408 28-Aug-98

Homo sapiens genomic clone Plate＝3098 Col＝5 Row＝E，genomic survey

sequence.rxa01253 873 GB_PL2：F5O8 99923 AC005990 Arabidopsis thaliana chromosome 1 BAC F5O8 sequence，complete Arabidopsis thaliana 36,118 23-DEC-

sequence. 1998

GB_PL2：F5O8 99923 AC005990 Arabidopsis thaliana chromosome 1 BAC F5O8 sequence，complete Arabidopsis thaliana 35,574 23-DEC-

sequence. 1998

GB_IN1：CELC06G1 31205 LU41014 Caenorhabditis eiegans cosmid C06G1. Caenorhabditis elegans 38,560 30-Nov-95

Table 4 (continuous) rxa 013211044 GB _ GSS 14: AQ 51884441 AQ518843 HS _5106_ A1_ D10_ SP6E RPC1-11 Human Large BAC Library Homo sapiens 41,12105-MAY-

3 genornic clone Plate＝682 Col＝19 Row＝G，genomic survey sequence. 1999

GB_HTG2：AC007473 194859 AC007473 Drosophila melanogaster chromosome 2 clone BACR38D12 (D590) RPCI-98 Drosophila melanogaster 40,634 2-Aug-99

38.D. 12 map 48A-48B strain y；cr bw sp，^***SEQUENCING IN PROGRESS

^***，60 unordered pieces.

GB_HTG4：AC011696 115847 AC011696 Drosophila melanogaster chromosome 2 clone BACR35F01 (D1156) RPCI-98 Drosophila melanogaster 38,290 26-OCT-

35.F.1 nap 48A-48C strain y；cn bw sp，^***SEQUENCING IN PROGRESS 1999

^***，108 unordered pieces.rxa01352 706 GB_PL2：ATAC005167 83260 AC005167 Arabidopsis thaliana chromosome II BAC F12A24 genomic sequence， Arabidopsis thaliana 34,311 15-OCT-

complete secluence. 1998

GB_PL2：ATAC005825 97380 AC005825 Arabldopsis thaliana chromosome II 8AC T24121 genomic sequence， Arabidopsis thaliana 34,311 12-Apr-99

complete sequence.

GB_HTG3：AC011150 127222 AC011150 Homo sapiens clone 4_K_17，LOW-PASS SEQUENCE SAMPLING. Homo sapiens 37,722 01-OCT-

1999rxa01360 259 GB_EST32：AI725583 728 AI725583 BNLGHi12371 Six-day Cotton fiber Gossypium hirsutum cDNA 5′similar to Gossypium hirsutum 38,492 11-Jun-99

(U86081) root hair defective 3 [Arabidopsis thaliana]，mRNA sequence.

GB_PR2：HS227P17 82951 Z81007 Human DNA sequence from PAC 227P17，between markers DXS6791 Homo sapiens 39,738 23-Nov-99

andDXS8038 on chromosome X contains CpG island，EST.

GB_EST34：AV171099 173 AV171099 AV171099 Mus musculus head C57BL/6J 14，17 day embryo Mus musculus Mus musculus 46,237 6-Jul-99

cDNA clone 3200002M11，mRNA sequence.rxa01361 629GB_RO：AB008915S1 530 AB008915 Mus musculus mGpi1 gene，exon 1. Mus musculus 45,574 28-Sep-99

GB_EST22：AI050532 293 AI050532 uc83d10.y1 Sugano mouse kidney mkia Mue musculus cDNA clone Mus musculus 44,097 9-Jul-98

IMAGE：1432243 5′similar to TR：O35120 035120 MGPI1P.；，mRNA

sequence.

GB_RO：AB008895 3062 AB008895 Mus musculus mRNA for mGpi1p，complete cds. Mus musculus 41,316 23-Nov-97rxa01381 944 GB_PL1：AB005237 87835 AB005237 Arabidopsis thaliana genomic DNA，chromosome 5，P1 clone：MJJ3，complete Arabidopsis thaliana 36,606 20-Nov-99

sequence.

GB_GSS5：AQ766840 491 AQ766840 HS_2026_A2_C09_T7C CIT Approved Human Genomic Sperm Library D Homo sapiens 37,916 28-Jul-99

Homo sapiens genomic clone Plate＝2026 Col＝18 Row＝E，genomic survey

sequence.

GB_BA1：MTV043 68848 AL022004 Mycobacterium tuberculosis H37Rv complete genome；segment 40/162. Mycobacterium 37,419 24-Jun-99

tuberculosisrxa01393 993 GB_BA1：CGLYSEG 2374 X96471 C.glutamicum lysE and lysG genes. Corynebacterium 34,831 24-Feb-97

glutamicum

GB_BA1：SC5A7 40337 AL031107 Streptomyces coelicolor cosmid 5A7. Streptornyces coelicolor 35,138 27-Jul-98

GB_PR3：AC004054 112184 AC004054 Homo sapiens chromosome 4 clone B220G8 map 4q21，complete sequence. Homo sapiens 37,277 9-Jul-98rxa01394 822 GB_BA1：CGLYSEG 2374 X96471 C.glutamicum lysE and lysG genes. Corynebscterium 100,000 24-Feb-97

glutamicum

GB_GSSS：AQ769223 500 AQ769223 HS_3155_B2_G10_T7C CIT Approved Human Genomic Sperm Library D Homo sapiens 38,400 28-Jul-99

Homo sapiens genomic clone ptate＝3155 Col＝20 Row＝N，genomic survey

sequence.

Table 4 (continuation)

GB_BA1：CGLYSEG3 2374 X96471 C.glutamicum lysE and lysG genes. Corynebacterium 33,665 24-Feb-97

glutamicumrxa01416 630 GB_BA1：SC3C3 31382 AL031231 Streptomyces coelicolor cosmid 3C3. Streptomyces coelicolor 62,726 10-Aug-98

GB_BA1：MLCB22 40281 Z98741 Mycobacterium leprae cosmid B22. Mycobacterium leprae 39,159 22-Aug-97

GB_BA1：MTV002 56414 AL008967 Mycobacterium tuberculosis H37Rv complete genome；segment 122/162. Mycobacterium 37,340 17-Jun-98

tuberculosisrxa01442 1347 GB_BA1：D90827 18886 D90827 E.coli genomic DNA，Kohara clone #336(41.2-41.6min.). Escherichia coli 58,517 21-MAR-

1997

GB_BA1：D90828 14590 D90828 E.coli genomic DNA，Kohara clone #336gap(41.6-41.9min.). Escherichia coli 56,151 21-MAR-

1997

GB_BA2：AE000279 10855 AE000279 Escherichia coli K-12 MG1655 section 169 of 400 of the complete genome. Escherichia coli 56,021 12-Nov-98rxa01446 1413 GB_BA1：SCH10 39524 AL049754 Streptomyces coelicolor cosmid H10. Streptomyces coelicolor 39,037 04-MAY-

1999

GB_BA1：MTY13E10 35019 Z95324 Mycobacterium tubercutosis H37Rv complete genome；segment 18/162. Mycobacterium 40,130 17-Jun-98

tuberculosis

GB_BA1：MLCB4 36310 AL023514 Mycobacterium leprae cosmid B4. Mycobacterium leprae 37,752 27-Aug-99rxa01483 1395 GB_BA1：MTCY98 31225 Z83860 Mycobacterium tuberculosis H37Rv complete genome；segment 103/162. Mycobacterium 39,057 17-Jun-98

tuberculosis

GB_BA1：MSGB1229C 30670 L78812 Mycobacterium leprae cosrnid B1229 DNA sequence. Mycobacterium leprae 54,382 15-Jun-96

S

GB_BA2：AF027507 5168 AF027507 Mycobacterium smegmatis dGTPase (dgt)，and primase (dnaG) genes， Mycobacterium smegmatis 52,941 16-Jan-98

complete cds；tRNA-Asn gene，complete sequence.rxa01486 757 GB_BA1：MTV002 56414 AL008967 Mycobacterium tuberculosis H37Rv complete genome；segment 122/162. Mycobacterium 40,941 17-Jun-98

uberculosis

GB_BA1：MLCB22 40281 Z98741 Mycobacterium leprae cosmid B22. Mycobacterium leprae 38,451 22-Aug-97

GB_BA1：SC3C3 31382 AL031231 Streptomyces coelicolorcosmid 3C3. Streptomyces coelicolor 61,194 10-Aug-98rxa01489 1146 GB_BA1：CORFADS 1547 D37967 Corynebacterium ammoniagencs gene for FAD synthetase，complete cds. Corynebacterium 58,021 8-Feb-99

ammoniagenes

GB_BA1：MLCB22 40281 Z98741 Mycobacterium leprae cosmid B22. Mycobacterium leprae 38,414 22-Aug-97

GB_BA1：SC10A7 39739 AL078618 Streptomyces coelicotor cosmid 10A7. Streptomyces coelicolor 36,930 9-Jun-99rxa01491 774 GB_BA1：MTV002 56414 AL008967 Mycobacterium tuberculosis H37Rv complete genome；segment 122/162. Mycobacterium 37,062 17-Jun-98

tuberculosis

GB_EST13：AA356956 255 AA356956 EST65614 Jurkcat T-cells III Homo sapiens cDNA 5′end，mRNA sequence. Homo sapiens 37,647 21-Apr-97

GB_OV：OMDNAPROI 7327 X92380 O.mossambicus prolactin I gene. Tilapia mossambica 38,289 19-OCT-

1995rxa01508 1662 GB_IN1：CEF28C12 14653 Z93380 Caenorhabditis elegans cosmid F28C12，complete sequence. Caenorhabditis elegans 37,984 23-Nov-98

GB_IN1：CEF28C12 14653 Z93380 Caenorhablitis elegans cosmid F28C12，complete sequence. Caenorhabditis elegans 38,469 23-Nov-98rxa01512 723 GB_BA1：SCE9 37730 AL049841 Streptomyces coelicolor cosmid E9. Streptomyces coelicolor 39,021 19-MAY-

1999

GB_BA1：MAU88875 840 U88875 Mycobacterium avium hypoxanthine-guanine phosphoribosyl transferase Mycobacterium avium 57,521 05-MAR-

gene，complete cds. 1997

Table 4 (continuation)

GB_BA1：MTY15C10 33050 Z95436 Mycobacterium tuberculosis H37Rv complete genome；segment 154/162. Mycobacterium 40,086 17-Jun-98

tuberculosisrxa01514 711 GB_BA1：MTCY7H7B 24244 Z95557 Mycobacterium tuberculosis H37Rv complete genome；segment 153/162. Mycobacterium 43,343 18-Jun-98

tuberculosis

GB_BA1：MLCB2548 38916 AL023093 Mycobacterium leprae cosmid B2548. Mycobacterium leprae 38,177 27-Aug-99

GB_PL1：EGGTPCHI 242 Z49757 E.gracilis mRNA for GTP cyclohydrolase I (core region). Euglena gracilis 64,876 20-OCT-

1995rxa01515 975 GB_BA1：ECOUW93 338534 U14003 Escberichia coli K-12 chromosomal region from 92.8 to 00.1 minutes. Escherichia coli 38,943 17-Apr-96

GB_BA1：ECOUW93 338534 U14003 Escherichia coli K-12 chromosomal region from 92.8 to 00.1 minutes. Escherichia coli 37,500 17-Apr-96

GB_BA1：MTCY49 39430 Z73966 Mycobacterium tuberculosis H37Rv complete genome；segment 93/162. Mycobacterium 38,010 24-Jun-99

tuberculosisrxa01516 513 GB_IN1：DME238847 5419 AJ238847 Drosophila melanogaster mRNA for drosophila dodeca-satellite protein 1 Drosophila melanogaster 36,346 13-Aug-99

(DDP-1).

GB_HTG3：AC009210 103814 AC009210 Drosophila melanogaster chromosome 2 clone BACR01106 (D1054) RPCI-98 Drosophila melanogaster 37,897 20-Aug-99

01.1.6 map 55D-55D strain y；cn bw ap，^***SEQUENCING IN PROGRESS

^***，86 unordered pieces.

GB_IN2：AF132179 4842 AF132179 Drosophila melanogaster clone LD21677 unknown mRNA. Drosophila melanogaster 36,149 3-Jun-99rxa01517 600 GB_PL2：F6H8 82596 AF178045 Arabidopsis thaliana BAC F6H8. Arabidopsis thaliana 35,846 19-Aug-99

GB_PL2：AF038831 647 AF038831 Sorosporium saponariae intenal transcribed spacer 1，5.8S ribosornal RNA Sorosporium saponarise 40,566 13-Apr-99

gene；and internal transcribed spacer 2，complete sequence.

GB_PL2：ATAC005957 108355 AC005957 Arabidopsis thaliana chromosome II BAC T15J14 genomic sequence， Arabidopsis thaliana 38,095 7-Jan-99

complete sequence.rxa01521 921 GB_BA1：ANANIFBH 5936 J05111 Anabsena ap. (clone AnH20.1) nitrogen fixation operon nirB，foxN，nitS，nifU， Anabaena sp. 38,206 26-Apr-93

and nifH genes，complete cds.

GB_PR2：AC002461 197273 AC002461 Human BAC clone RG204116 from 7q31，complete sequence. Homo sapiens 36,623 20-Aug-97

GB_PR2：AC002461 197273 AC002461 Human BAC clone RG204116 from 7q31，complete sequence. Homo sapiens 34,719 20-Aug-97rxa01528 651 GB_RO：MM437P9 165901 AL049866 Mus musculus chromosome X，clone 437P9， Mus musculus 37,500 29-Jun-99

GB_PR3：AC005740 186780 AC005740 Homo sapiens chromosome 5p，BAC clone 50g21 (LBNL H154)，complete Homo sapiens 37,031 01-OCT-

sequence. 1998

GB_PR3：AC005740 186780 AC005740 Homo sapiens chromosome 5p，BAC clone 50921 (LBNL H154)，complete Homo sapiens 38,035 01-OCT-

sequence. 1998rxa01551 1998 GB_BA1：MTCY22G10 35420 Z84724 Mycobacterium tuberculosis H37Rv complete genome；segment 21/162. Mycobacterium 38,371 17-Jun-98

tuberculosis

GB_BA2：ECOUW89 176195 U00006 E.coli chromosomal region from 89.2 to 92.8 minutes， Escherichia coli38,064 17-DEC-

1993

GB_BA1：SCQ11 15441 AL096823 Streptomyces coelicolor cosmid Q11. Streptomyces coelicolor 60,775 8-Jul-99rxa01561 1053 GB_IN1：CEY62H9A 47396 AL032630 Caenorhabditis elegans cosmid Y62H9A，complete sequence. Caenorhabditis elegans 38,514 2-Sep-99

GB_PR4：HSU51003 3202 U51003 Homo sapiens DLX-2 (DLX-2) gene，complete cds. Homo sapiens 37,730 07-DEC-

1999

GB_OM：PIGDAO1 395 M18444 Pig D-amino acid oxidase (DAO) gene，exon 1. Sus scrofa 39,340 27-Apr-93rxa01599 1785 GB_BA1：MTCI125 37432 Z98268 Mycobacteriuo tuberculosis H37Rv complete genome；segment 76/162. Mycobacterium 63,300 17-Jun-98

tuberculosis

GB_BA1：U00021 39193 U00021 Mycobacterium leprae cosmid L247. Mycobacterium leprae 36,756 29-Sep-94

Table 4 (continuation)

GB_BA1：MLCB1351 38936 Z95117 Mycobacterium leprae cosmid B1351. Mycobacterium leprae 36,756 24-Jun-97rxa01617 795 GB_PR2：HSMTM0 217657 AL034384 Human chromosome Xq28，cosmid clones 7H3，14D7，C1230，11E7，F1096， Homo sapiens 40,811 5-Jul-99

A12197，12G38，A09100；complete sequence bases 1..217657.

GB_PR2：HS13D10 153147 AL021407 Homo sapiens DNA sequence from PAC 13D10 on chromosome 6p22.3-23. Homo sapiens 38,768 23-Nov-99

Contains CpG island.

GB_PR2：HSMTM0 217657 AL034384 Human chromosome Xq28，cosmid clones 7H3，14D7，C1230，11E7，F1096， Homo sapiens 39,018 5-Jul-99

A12197，12G8，A09100；complete sequence bases 1..217657.rxa01557 723 GB_BA1：MTCY1A10 25949 Z95387 Mycobacterium tuberculosis H37Rv complete genome；segment 117/162. Mycobacterium 40,656 17-Jun-98

tuberculosis

GB_EST6：D79278 392 D79278 HUM213D06B Human aorta polyA+ (TFujiwara) Homo sapiens cDNA clone Homo sapiens 44,262 9-Feb-96

GEN-213D06 5′，mRNA sequence.

GB_BA2：AF129925 10243 AF129925 Thiobacillus ferrooxidans carboxysome operon，complete cds. Thiobacillus ferrooxidans 40,709 17-MAY-

1999rxa01660 675 GB_BA1：MTV013 11364 AL021309 Mycobacterium tuberculosis H37Rv complete genome；segment 134/162 Mycobactetium 40,986 17-Jun-98

tuberculosis

GB_RO：MMFV1 6480 X97719 M.musculus retrovirus restriction gene Fv1. Mus musculus 35,364 29-Aug-96

GB_PAT：A67508 6480 A67508 Sequence 1 from Patent WO9743410. Mus musculus 35,364 05-MAY-

1999rxa01678 651 GB_VI：TVU95309 600 U95309 Tula virus O64 nucleocapsid protein gene，partial cds. Tula virus 41,894 28-OCT-

1997

GB_VI：TVU95303 600 U95303 Tula virus O52 nucleocapsid protein gene，partial cds.Tula virus 41,712 28-OCT-

1997

GB_VI：TVU95302 600 U95302 Tula virus O24 nucleocapsid protein gene，partial cds. Tula virus 39,576 28-OCT-

1997rxa01679 1359 GB_EST5：H91843 362 H91843 ys81e0t.s1 Soares retina N2b4HR Homo sapiens cDNA clone Homo sapiens 39,157 29-Nov-95

IMAGE：221208 3′similar to gb：X63749_ma1 GUANINE NUCLEOTIDE-

BINDING PROTEIN G(T)，ALPHA-1 (HUMAN)；mRNA sequence.

GB_STS：G26925 362 G26925 human STS SHGC-30023，sequence tagged site. Homo sapiens 39, 157 14-Jun-96

GB_PL2：AF139451 1202 AF139451 Gossypium robinsonii CelA2 pseudogene，partial sequence. Gossypium robinsonii 38,910 1-Jun-99rxa01690 1224 GB_BA1：SC1C2 42210 AL031124 Streptomyces coelicolor cosmid 1C2. Streptomyces coelicolor 60,644 15-Jan-99

GB_EST22：AI064232 493 Al064232 GH04563.5prime GH Drosophila melanogaster head pOT2 DrosophilaDrosophila melanogaster 38,037 24-Nov-98

melanogaster cDNA clone GH04563 5prime，mRNA sequence.

GB_IN2：AF117896 1020 AF117896 Drosophila melanogaster neuropeptide F (npf) gene，complete cds. Drosophila melanogaster 36,122 2-Jul-99rxa01692 873 GB_BA2：AF067123 1034 AF067123 Lactobacillus reuteri cobelamin biosynthesis protein J (cbiJ) gene，partial cds； Lactobacillus reuteri 48,079 3-Jun-98

and uroporphyrin-III C-methyltransferase (sumT) gene，complete cds.

GB_RO：RATNFHPEP 3085 M37227 Rat heavy neurofilament (NF-H) polypeptide，partial cds. Rsttus norvegicus 37,093 27-Apr-93

GB_RO：RSNFH 3085 X13804 Rat mRNA for heavy neurofilament polypeptide NF-H C-terminus. Rattus sp 37,093 14-Jul-95rxa01698 1353 GB_BA2：AF124600 4115 AF124600 Corynebacterium glutamicum chorismate synthase (aroC)，shikimate kinase Corynebacterium 100,000 04-MAY-

(aroK)，and 3-dehydroquinate synthase (aroB) genes，complete cds：and glutamicum 1999

putative cytoplasmic peptidase (pepQ) gene，partial cds

GB_BA1 ：MTCY159 33818 Z83863 Mycobacterium tuberculosis H37Rv complete genome；segment 111/162. Mycobacterium 36,323 17-Jun-98

tuberculosis

Table 4 (continuation)

GB_BA1：MSGB937C 38914 L78820 Mycobacterium leirae cosmid B937 DNA sequence. Mycobacterium leprae 62,780 15-Jun-96

Srxa01699 693 GB_BA2：AF124600 4115 AF124500 Corynebacterium glutamicum chorisrnate synthase (aroC)，shikimate kinase Corynebacterium 100,000 04-MAY-

(aroK)，and 3-dehydroquinate synthase (aroB) genes，complete cds；and glutamicum 1999

putative cytoplasmic peptidase (pepQ) gene，partial cds.

GB_BA2：AF016585 41097 AF016585 Streptomyces caelestis cytochrome P-450 hydroxylase homolog (nidi) gene， Streptomyces caelestis 40,260 07-DEC-

partial cds；polyketide synthase modules 1 through 7 (nidA) genes，complete 1997

cds；and N-methyltransferase homolog gene，partial cds.

GB_EST9：C19712 399 C19712 C19712 Rice panicle at ripening stage Oryza sativa cDNA clone E10821_1A， Oryza sativa 45,425 24-OCT-

mRNA sequence. 1996rxa01712 805 GB_EST21：AA952466 278 AA952466 TENS1404 T.cruzi epimastigote normalized cDNA Library Trypanosoma cruzi Trypanosoma cruzi 40,876 29-OCT-

cDNA clone 1404 5′，mRNA sequence. 1998

GB_EST21：AA952466 278 AA952466 TENS1404 T.cruzi epimastigote normalized cDNA Library Trypanosoma cruzi Trypanosoma cruzi 41,367 29-OCT-

cDNA clone 1404 5′，mRNA sequence. 1998rxa01719 684 GB_HTG1：HSDJ534K 154416 AL109925 Homo sapiens chromosome 1 clone RP4-534K7，^***SEQUENCING IN Homo sapiens 35,651 23-Nov-99

7 PROGRESS^***，in unordered pieces.

GB_HTG1：HSDJ534K 154416 AL109925 Homo sapiens chromosome 1 clone RP4-534K7，^***SEQUENCING IN Homo sapiens 35,651 23-Nov-99

7 PROGRESS^***，in unondered pieces.

GB_EST27：AI447108 431 AI447108 mq91e08.x1 Stratagene mouse heart (#937316) Mus musculus cDNA clone Mus musculus 39,671 09-MAR-

IMAGE：586118 3′，mRNA sequence. 1999rxa01720 1332 GB_PR4：AC006322 179640 AC006322 Homo sapiens PAC clone DJ1060B11 from 7q11.23-q21.1，complete Homo sapiens 35,817 18-MAR-

sequence. 1999

GB_PL2：TM018A10 106184 AF013294 Arabidopsis thaliana BAC TM018A10. Arabidopsis thaliana 35,698 12-Jul-97

GB_PR4：AC006322 179640 AC006322 Homo sapiens PAC clone DJ1060B11 from 7q11.23-q21.1，complete Homo sapiens 37,243 18-MAR-

sequence. 1999rxa01746 876 GB_EST3：R46227 443 R46227 yg52a03.s1 Soares infant brain 1NIB Homo sapiens cDNA clone Homo sapiens 42,812 22-MAY-

IMAGE：36000 3′，mRNA sequence. 1995

GB_EST3：R46227 443 R46227 yg52a03.s1 Soares infant brain 1NIB Homo sapiens cDNA clone Homo sapiens 42,655 22-MAY-

IMAGE：36000 3′，mRNA sequence. 1995rxa01747 1167 GB_BA1：MTCY190 34150 Z70283 Mycobacterium tuberculosis H37Rv complete genome；segment 98/162. Mycobacterium 59,294 17-Jun-98

tuberculosis

GB_BA1：MLCB22 40281 Z98741 Mycobacterium leprae cosmid B22. Mycobacterium leprae 57,584 22-Aug-97

GB_BA1：SC5F7 40024 AL096872 Streptomyces coelicolor cosmid 5F7. Streptomyces coelicolor 61,810 22-Jul-99

A3(2)rxa01757 924 GB_EST21：AA918454 416 AA918454 om38c02.s1 Soares_NFL_T_GBC_S1 Homo sapiens cDNA clone Homo sapiens 39,655 23-Jun-98

IMAGE：1543298 3′similar to WP：F28F8.3 CE09757 SMALL NUCLEAR

RIBONUCLEOPROTEIN E ；，mRNA sequence.

GB_EST4：H34042 345 H34042 EST110563 Rat PC-12 cells，NGF-treated (9 days) Rattus sp. cDNA clone Rattus sp. 35,942 2-Apr-98

RPNBI81 5′end，mRNA sequence.

GB_EST20：AA899038 450 AA899038 NCP6G8T7 Perithecial Neurospora crassa cDNA clone NP6G8 3′end，mRNA Neurospora crassa 40,000 12-Apr-98

sequence.

Table 4 (continuation) rxa 01807915 GB _ BA 1: AP 000063185300 AP000063 Aeropyrum pemix genomic DNA, section 6/7 Aeropyrum pemix 40,06722-Jun-99

GB_HTG4：AC010694 115857 AC010694 Drosophila melanogaster clone RPCI98-6H2，^***SEQUENCING IN Drosophila melanogaster 35,450 16-OCT-

PROGRESS^***，75 unordered pieces. 1999

GB_HTG4：AC010694 115857 AC010694 Drosophila melanogaster clone RPCI98-6H2，^***SEQUENCING IN Drosophila melanogaster 35,450 16-OCT-

PROGRESS^***，75 unordererd pieces. 1999rxa01821 401 GB_BA1：CGL007732 4460 AJ007732 Corynebacterium glutanmicum 3′ppc gene，secG gene，amt gene，ocd gene Corynebacterium 100,000 7-Jan-99

and 5′soxA gene. glutamicum

GB_RO：RATALGL 7601 M24108 Rattus norvegicus (clone A2U42) alpha2u globulin gene，exons 1-7. Rattus norvegicus 38,692 15-DEC-

1994

GB_OVAPIGY2 1381 X78272 Anas platyrhynchos (Super M) lgY upsilon heavy chain gene，exon 2. Anas platyrhynchos 36,962 15-Feb-99rxa0t835 654 GB_EST30AI629479 353 AI629479 486101D10.x1 486-leaf primordia cDNA library from Hake lab Zee mays Zea mays 38,109 26-Apr-99

cDNA，mRNA sequence.

GB_STS：G48245 515 G48245 SHGC-62915 Human Homo sapiens STS genomic，sequence tagged site. Homo sapiens 37,021 26-MAR-

1999

GB_GSS3：B49052 515 B49052 RPCI11-4112.TV RPCI-11 Homo sapiens genomic clone RPCI-11-4112， Homo sapiens 37,021 8-Apr-99

genomic survey sequence.rxa01850 1470 GB_BA2：ECOUW67_ 110000 U18997 Escherichia coli K-12 chromosomal region from 67.4 to 76.0 minutes. Escherichia coli 37,196 U18997

0

GB_BA2：AE000392 10345 AE000392 Escherichia coli K-12 MG1655 section 282 of 400 of the complete genome. Escherichia coli 38,021 12-Nov-98

GB_BA2：U32715 13136 U32715 Haemophilus influenzae Rd section 30 of 163 of the complete genome. Haemophilus influenzae 39,860 29-MAY-

Rd 1998rxa01878 1002 GB_HTG1：CEY64F11 177748 Z99776 Caenorhabditis elegans chromosome IV clone Y64F11，^***SEQUENCING IN Caenorhabditis elegans 37,564 14-OCT-

PROGRESS^***，in unordered pieces. 1998

GB_HTG1：CEY64F11 177748 Z99776 Caenorhabditis eiegans chromosome IV clone Y64F11，^***SEQUENCING IN Caenorhabditis elegars 37,564 14-OCT-

PROGRESS^***，in unorderod pieces. 1998

GB_HTG1：CEY64F11 177748 Z99776 Caenorhabditis elegans chromosome IV clone Y64F11，^***SEQUENClNG IN Caenorhabditis elegans 37,576 14-OCT-

PROGRESS^***，in unordered pieces. 1998rxa01892 852 GB_BA1：MTCY274 39991 Z74024 Mycobacterium tuberculosis H37Rv complete genome；segment 126/162. Mycobacterium 35,910 19-Jun-98

tuberculosis

GB_BA1：MLCB250 40603 Z97369 Mycobacterium leprae cosmid B250. Mycobacterium leprae 64,260 27-Aug-99

GB_BA1：MSGB1529C 36985 L78824 Mycobacterium leprae cosmid B1529 DNA sequence. Mycobacterium leprae 64,260 15-Jun-96

Srxa01894 978 GB_BA1：MTCY274 39991 Z74024 Mycobacterium tuberculosis H37Rv complete genome；segmont 126/162. Mycobacterium 37,229 19-Jun-98

tuberculosis

GB_IN1：CELF46H5 38886 U41543 Caenorhabditis elegans cosmid F46H5. Caenorhabditis elegans 38,525 29-Nov-96

GB_HTG3：AC009204 115633 AC009204 Drosophila melanogaster chromosome 2 clone BACR03E19 (D1033) RPCl-98 Drosophila melanogaster 31,579 18-Aug-99

03.E.19 map 36E-37C strain y；cn bw sp，^***SEQUENCING IN PROGRESS

^***，94 unordered pieces.rxa01920 1125 GB_BA2：AF112536 1798 AF112536 Corynebacterium glutamicum ribonucleotide reductase beta-chain(nrdF) Corynebacterium 99,733 5-Aug-99

gene，complete cds. glutamicum

GB_BA1 ：CANRDFGE 6054 Y09572 Corynebacterium ammoniagenes nrdH，nrdI，nrdE，nrdF genes. Corynebacterium 70,321 18-Apr-98

N ammoniagenes

Table 4 (continuation)

GB_BA2：AF050168 1228 AF050168 Corynebacterium ammoniagenes ribonucleoside diphosphate reductase small Corynebacterium 72,082 23-Apr-98

subunit (nrdF) gene，complete cds. ammoniagenesrxa01928 960 GB_BA1：CGPAN 2164 X96580 C.glutamicum panB，panC&xylB genes. Corynebacterium 100,000 11-MAY-

glutamicum 1999

GB_PL1：AP000423 154478 AP000423 Arabkdopsis thaliana chloroplast genomic DNA，complete sequence. Chloroplast Arabidopsis 35,917 15-Sep-99

strain；Columbia. thaliana

GB_PL1：AP000423 154478 AP000423 Arabidopsis thaliana chloroplast genomic DNA，complete sequence， Chloroplast Arabidopsis 33,925 15-Sep-99

strain；Columbia. thalianarxa01929 936GB_BA1：CGPAN 2164 X96580 C.glutamicum panB，panC&xylB genes. Corynebacterium 100,000 11-MAY-

glutamicum 1999

GB_BA1：XCU33548 8429 U33548 Xanthomonas campestris hrpB pathogenity locus proteins HrpB1，HrpB2， Xanthomonas campestris 38,749 19-Sep-96

HrpB3，HrpB4，HrpB5，HrpB6，IrpB7，HrpB8，HrpA1，and ORF62 pv.vesicatoria

genes，complete cds.

GB_BA1：XANHRPB6 1329 M99174 Xanthomonas campestris hrpB6 gene，complete cds. Xanthomonas campestris 39,305 14-Sep-93

Arxa01940 1059 GB_IN2：CFU43371 1060 U43371 Crithidia fasciculata inosine-uridine preferring nucleoside hydrolase (IUNH) Crithidia fasciculata 61,417 18-Jun-96

gene，complele cds.

GB_BA2：AE001467 11601 AE001467 Helicobacter pylori，strain J99 section 28 of 132 of the complete genome. Helicobacter pylori J99 38,560 20-Jan-99

GB_RO：AF175967 3492 AF175967 Homo sapiens Leman coiled-coil protein (LCCP) mRNA，complete cds. Mus musculus 40,275 26-Sep-99rxa02022 1230 GB_BA1：CGDAPE 1966 X81379 C.glutamicum dapE gene and orf2. Corynebacterium 100,000 8-Aug-95

glutamicum

GB_BA1：CGDNAARO 2612 X85965 C.glutamicum ORF3 and aroP gene. Corynebacterium 38,889 30-Nov-97

P glutamicum

GB_BA1：APU47055 6469 U47055 Anabaena PCC7120 nitrogen fixation proteins (nifE，nifN，nifX，nifVV) genes， Anabaena PCC7120 36,647 17-Feb-96

complete cds，and nitrogenase (nifK) and hesA genes；partial cds.rxa02024 859 GB_BA1：MTCI364 29540 Z93777 Mycobacterium tuberculosis H37Rv complete genome；segment 52/162. Mycobacterium 59,415 17-Jun-98

tuberculosis

GB_BA1：MSGB1912C 38503 L01536 M.leprae genomic dna sequence，cosmid b1912. Mycobacterium leprae 57,093 14-Jun-96

S

GB_BA1：MLU15180 38675 U15180 Mycobacterium leprae cosmid B1756. Mycobacterium leprae 57,210 09-MAR-

1995rxa02027rxa02031rxa02072 1464 GB_BA1：CGGDHA 2037 X72855 C.glutamicum GDHA gene. Corynebacterium 99,317 24-MAY-

glutamicum 1993

GB_BA1：CGGDH 2037 X59404 Corynebacterium glutamicum，gdh gen for glutamate dehydrogenase. Corynebacterium 94,387 30-Jul-99

glutamicum

GB_BA1：PAE18494 1628 Y18494 Pseudomonas aeruginosa gdhA gene，strain PAC1. Pseudomonas aeruginosa 62,247 6-Feb-99

Table 4 (continuous) rxa 020852358 GB _ BA 1: MTCY22G 822550Z 95585 Mycobacterium tuberculosis H37Rv complete genome; segment 49/162 Mycobacterium 38,44217-Jun-98

tuberculosis

GB_BA1：MLCB33 42224 Z94723 Mycobacterium leprae cosmid B33. Mycobacterium leprae 56,486 24-Jun-97

GB_BA1：ECOUW85 91414 M87049 E.coli genomic sequence of the region from 84.5 to 86.5 minutes. Escherichia coli 52,127 29-MAY-

1995rxa02093 927 GB_EST14：AA448146 452 AA448146 zw82h01.r1 Soares_testis_NHT Homo sapiens cDNA clone IMAGE：782737 Homo sapiens 34,163 4-Jun-97

5′，mRNA sequence.

GB_EST17：AA641937 444 AA641937 ns18b10.r1 NCI_CGAP_GCB1 Homo sapiens cDNA clone IMAGE：1183963 Homo sapiens 35,586 27-OCT-

5′，mRNA sequence. 1997

GB_PR3：AC003074 143029 AC003074 Human PAC clone DJ0596009 from 7p15，complete sequence. Homo sapiens 31,917 6-Nov-97rxa02106 1179 GB_BA1：SC1A6 37620 AL023496 Streptomyces coelicolorcosmid 1A6. Streptomyces coelicolor 35,818 13-Jan-99

GB_PR4：AC005553 179651 AC005553 Homo sapiens chromosome 17，clone hRPK.112_J_9，complete sequence. Homo sapiens 34,274 31-DEC-

1998

GB_EST3：R49746 397 R49746 yg71g10.r1 Soares infant brain 1NIB Homo sapiens cDNA clone Homo sapiens 41,162 18-MAY-

IMAGE：38768 5′similar to gb：V00567 BETA-2-MICROGLOBULIN 1995

PRECURSOR (HUMAN)；，mRNA sequence.rxa02111 1407 GB_BA1：SC6G10 36734 AL049497 Streptomyces coelicolor cosmid 6G10. Streptomyces coelicolor 50,791 24-MAR-

1999

GB_BA1：U00010 41171 U00010 Mycobacterium leprae cosmid B1170. Mycobacteriun leprae 37,563 01-MAR-

1994

GB_BA1：MTCY336 32437 Z95586 Mycobacterium tuberculosis H37Rv complete genome；segment 70/162. Mycobacterium 39,504 24-Jun-99

tuberculosisrxa02112 960 GB_HTG3：AC010579 157658 AC010579 Drosophile melanogsater chromosome 3 clone BACR09D08 (D1101) RPCl-98 Drosophila melanogaster37,909 24-Sep-99

09.D.8 map 96F-96F strain y；cn bw sp，^***SEQUENCING IN PROGRESS

^***，121 unordered pieces.

GB_GSS3：809839 1191 B09839 T12A12-Sp6 TAMU Arabidopsis thaliana genomic clone T12A12，geromic Arabidopsis thaliana 37,843 14-MAY-

sunvey sequence. 1997

GB_HTG3：AC010579 157658 AC010579 Drosophila melanogaster chromosome 3 clone BACR09D08 (D1101) RPCI-98 Drosophila melanogaster 37,909 24-Sep-99

09.D.8 map 96F-96F strain y；cn bw sp，^***SEQUENCING IN PROGRESS

^***，121 unordered pieces.rxa02134 1044 GB_BA1：SCSECYDN 6154 X83011 S.coelicolor secY locus DNA. Streptomyces coelicolor 36,533 02-MAR-

A 1998

GB_EST32：AI731596 568 AI731596 BNLGHi10185 Six-day Cotton fiber Gossypium hirsutum cDNA 5′similar to Gossypium hirsutum 33,451 11-Jun-99

(AC004005) putative ribosomal protein L7 [Arabidopsis thaliana]，mRNA

sequence.

GB_BA1：SCSECYDN 6154 X83011 S.coelicolor secY locus DNA. Streptomyces coelicolor 36,756 02-MAR-

A 1998rxa02135 1197 GB_PR3：HS525L6 168111 AL023807 Human DNA sequence from clone RP3-525L6 on chromosome 6p22.3-23 Homo sapiens 34,365 23-Nov-99

Contains CA repeat，STSs，GSSs and a CpG Island，complete sequence.

GB_PL2：ATF21P8 85785 AL022347 Arabidopsis thaliana DNA chromosome 4，BAC clone F21P8 (ESSA project). Arabidopsis thaliana 34,325 9-Jun-99

GB_PL2：U89959 106973 U89959 Arabidopsis thaliana BAC T7123，complete sequence. Arabidopsis thaliana 33,874 26-Jun-98

Table 4 (continuation) rxa 02136645 GB _ PL 2: ATAC 00581957752 AC005819 Arabidopsis thaliana chromosome II BAC T3A4 genetic sequence, complete Arabidopsis thaliana 34,1233-Nov-98

sequence.

GB_PL2：F15K9 71097 AC005278 Arabidopsis thaliana chromosome 1 BAC F15K9 sequence，complete Arabidopsis thaliana 31,260 7-Nov-98

sequence.

GB_PL2：U89959 106973 U89959 Arabidopsis thaliana BAC T7123，complete sequence. Arabidopsis thaliana 34,281 26-Jun-98rxa02139 1962 GB_BA1：MTCY190 34150 Z70283 Mycobacterium tuberculosis H37Rv complete genome；segment 98/162. Mycobaclerium 62,904 17-Jun-98

tuberculosis

GB_BA1：MSGB1554C 36548 L78814 Mycobacterium leprae cosmid B1554 DNA sequence. Mycobacterium leprae 36,648 15-Jun-96

S

GB_BA1：MSGB1551C 36548 L78813 Mycobacteriurn leprae cosmid B1551 DNA sequence. Mycobacterium leplae 36,648 15-Jun-96

Srxa02153 903 GB_BA2：AF049897 9196 AF049897 Corynebacterium glutamicum N-acetylglutamylphosphate redtuctase (argC)， Corynebacterium 99,104 1-Jul-98

omithine acetyltransferase (ergJ)，N-acetylglutamate kinese (argB)， glutamicum

acetylornithine transaminase (argD)，omithine carbamoyltransferase

(argF)，arginine repressor (argR)，argininosuccinate syrthase (argG)，and

algininosuccinate lyase (argH) genes，complete cds.

GB_BA1：AF005242 1044 AF005242 Corynebacterium glutamicum N-ecetylglutamate-5-semialdehyde Corynebacterium 99,224 2-Jul-97

dehydrogenase (argC) gene，complete cds. glutamicum

GB_BA1：CGARGCJB 4355 X86157 C.glutamicum ergC，argJ，argB，argD，and argF genes. Corynebacterium 100,000 25-Jul-96

D glutamicumrxa02154 414 GB_BA2：AF049897 9196 AF049897 Corynebacterium glutamicum N-acetylglutamylphosphate reductase (argC)， Corynebacterium 98,551 1-Jul-98

omithine acetyltransferase (arg J)，N-acetylglutamate kinase (argB)， glutamicum

acetylornithine transaminase (argD)，omithine carbamoyltransferase (argF)，

erginine repressor (argR)，argininosuccinate synthase (argG)，and

argininosuccinate lyase (argH) genes，complete cds.

GB_BA1：AF005242 1044 AF005242 Corynebacterium glutamicum N-acetylglutamate-5-semialdehyde Corynebacterium 98,477 2-Jul-97

dehydrogenase (argC) gene，complete cds. glutamicum

GB_BA1：CGARGCJB 4355 X86157 C.glutamicum argC，ergJ，argB，argD，and argF genes. Corynebacterium 100,000 25-Jul-96

D glutarnicumrxa02155 1287 GB_BA1：CGARGCJB 4355 X86157 C.glutamicum argC，erg J，argB，argD，and argF genes. Corynebacterium 99,767 25-Jul-96

D glutanicum

GB_BA2：AF049897 9196 AF049897 Corynebacterium glutamicum N-acetylglutamylphosphate reductase (argC)， Corynebacferium 99,378 1-Jul-98

omithine acetyltransferase (argJ)，N-acetylglutamate kinese (argB)， glutamicum

acetylomithine transaminase (argD)，omithine carbamoyltransferase (argF)，

arginine repressor (argR)，argininosuccinate synthase (argG)，and

argininosuccinate lyase (argH) genes，comptete cds.

GB_BA1：MSGB1133C 42106 L78811 Mycobacterium leprae cosmid B1133 DNA sequence. Mycobacterium leprae 55,504 15-Jun-96

Srxa02156 1074 GB_BA2：AF049897 9196 AF049897 Corynebacterium glutamicum N-acetylglutamylphosphate reductase (argC)， Corynebacterium 100,000 1-Jul-98

omithine acetyltransferase (argJ)，N-acetylglutamate kinase (argB)， glutamicum

acetylomithine transaminase (argD)，omitnine carbamoyltransferase (argF).

arginine repressor (argR)，argininosuccinate synthase (argG)，and

argininosuccinate lyase (argH) genes，complete cds.

Table 4 (continuation)

GB_BA1：CGARGCJB 4355 X86157 C.glutamicum argC，argJ，argB，argD，and argF genes. Corynebacterium 100,000 25-Jul-96

D glutamicum

GB_BA2：AE001816 10007 AE001816 Thermotoga maritima section 128 of 136 of the complete genome. Thermotoga maritima 50,238 2-Jun-99rxa02157 1296 GB_BA2：AF049897 9196 AF049897 Corynebacterium glutamicum N-acetylglutamylphosphate reductase (argC)， Corynebacterium 99,612 1-Jul-98

ornithine acetyltransferase (argJ)，N-acetylglutamate kinase (argB)， glutamicum

acetylomithine transaminase (argD)，omithine carbamoylltransferase (argF)，

arginine repressor (argR)，argininoauccinate synthase (argG)，and

argininosuccinate lyase (argH) genes，comptete cds.

GB_BA1：CGARGCJB 4355 X86157 C.glutamicum argC，argJ，argB，argD，and argF genes. Corynebacterium 99,612 25-Jul-96

D glutamicum

GB_BA1：MTCY06H11 38000 Z85982 Mycobacterium tuberculosis H37Rv complete genome；segment 73/162. Mycobacterium 57,278 17-Jun-98

tuberculosisrxa02158 1080 GB_BA2：AF049897 9196 AF049897 Corynebacterium glutarnicum N-acetylglutamylphosphate reductase (argC). Corynebacterium 100,000 1-Jul-98

ornithine acetyltransferase (argJ)，N-aoetylglutamate kinase (argB)， glutamicum

acetylomithine transaminase (argD)，omithine carboamoyttransferase (argF)，

arginine repressor (argR)，argininosuccinate synthase (argG)，and

argininosucoinete lyase (argH) genes，complete ods.

GB_BA2：AF031518 2045 AF031518 Corynebacterium glutamicum omithine carbamolytransferase (argF) gene， Corynebacterium 99,898 5-Jan-99

complete cds. glutamicum

GB_BA1：CGARGCJB 4355 X86157 C.glutamicum argC，argJ，argB，argD，and argF genes. Corynebacterium 100,000 25-Jul-96

D glutamicumrxa02159 636 GB_BA2：AF049897 9196 AF049897 Corynebacterium glutemicum N-acetylgiutamylphosphate reductase (argC)， Corynebacterium 99,843 1-Jul-98

ornithine acetyltransferase (argJ)，N-acetylglutamate kinase (argB)， glutamicum

acetylomithine transaminase (argD)，ornithine carbamoyltransferase (argF)，

arginine repressor (argR)，argininosuccinate synthase (argG)，and

argininosuccinate lyase (argH) genes，complete cds.

GB_BA2：AF031518 2045 AF031518 Corynebacterium glutamicum omithine carb amolytransferase (argF) gene， Corynebacterium 88,679 5-Jan-99

complete cds. glutamicum

GB_BA2：AF041436 516 AF041436 Corynebacterium glutamicum arginine repressor (argR) gene，complete cds. Corynebacterium 100,000 5-Jan-99

glutamicumrxa02160 1326 GB_BA2：AF049897 9196 AF049897 Corynebacterium glutamicum N-acetylglutamylphosphate reductase (argC)， Corynebacterium 99,774 1-Jul-98

omithine acetyttransferase (argJ)，N-acetylglutamate kinase (argB)， glutamicum

acetylomithine transaminase (argD)，omithine carbamoyltransferase (argF)，

arginine repressor (argR)，argininosuccinate synthase (argG)，and

argininosuccinate lyase (argH) genes，complete cds.

GB_BA2：AF030520 1206 AF030520 Corynebacterium glutamicum argininosuccinate synthetase (argG) gene， Corynebacterium 99,834 19-Nov-97

complete cds.glutamicum

GB_BA1：SCARGGH 1909 Z49111 S.clavuligerus argG gene and argH gene (partial). Streptomyces clavuligerus 65,913 22-Apr-96rxa02162 1554 GB_BA2：AF049897 9196 AF049897 Corynebacterium glutamicum N-acetylglutamylphosphate reductase(argC)， Corynebacterium 88,524 1-Jul-98

omithine acetyltransferase (argJ)，N-acetylglutamate kinase (argB)， glutamicum

acetylornithine transaminase (argD)，omithine carbamoyltransferase (argF)，

arginine repressor (argR)，argininosuccinate synthase (argG)，and

argininosuccinate lyase (argH) genes，complete cds.

Table 4 (continuation)

GB_BA2：AF048764 1437 AF048764 Corynebacterium glutanicum argininosuccinate lyase (argH) gene，complete Corynebacterium 87,561 1-Jul-98

cds. glutamicum

GB_BA1：MTCY06H11 38000 Z85982 Mycobacterium tuberculosis H37Rv complete genome；segment 73/162. Mycobacterium 64,732 17-Jun-98

tuberculosisrxa02176 1251GB_BA1：MTCY31 37630 Z73101 MycobaCterium tuberculosis H37Rv complete genome；segment 41/162. Mycobacterium 36,998 17-Jun-98

tuberculosis

GB_BA1：CGGLTG 3013 X66112 C.glutamicum git gene for citrate synthase and ORF. Corynebacterium 39,910 17-Feb-95

glutamlcum

GB_PL2：PGU65399 2700 U65399 Basidiomycete CECT 20197 phenoloxidase (pox1) gene，complete cds. basidiomycete CECT 38,474 19-Jul-97

20197rxa02189 861 GB_PR3：AC002468 115888 AC002468 Human Chromosome 15q26.1 PAC clone pDJ417d7，complete sequence. Homo sapiens 35,941 16-Sep-98

GB_BA1：MSGB1970C 39399 L78815 Mycobacterium ieprae cosmid B1970 DNA sequence. Mycobacterium leprae 40,286 15-Jun-96

S

GB_PR3：AC002468 115888 AC002468 Human Chromosome 15q26.1 PAC clone pDJ417d7，complete sequence. Homo sapiens 33,689 16-Sep-98rxa02193 1701 GB_BA1 ：BRLASPA 1987 D25316 Brevibacterium flavum aspA gene for aspartase，complete cds. Corynebacterium 99,353 6-Feb-99

glutamicum

GB_PAT：E04307 1581 E04307 DNA encoding Brevibacterium flavum aspartase. Corynebacterium 99,367 29-Sep-97

glutamicum

GB_BA1 ：ECOUW93 338534 U14003 Escherichia coli K-12 chromosomal region from 92.8 to 00.1 minutes. Escherichia coli 37,651 17-Apr-96rxa02194 966 GB_BA2：AF050166 840 AF050166 Corynebacterium glutamicum ATP phosphoribosyltransferase(hisG)gene， Corynebacterium 98,214 5-Jan-99

complete cds. gtutarmicum

GB_BA1：BRLASPA 1987 D25316 Brevibacterium flavum aspA gene for aspartase，complete cds. Corynebacterium 93,805 6-Feb-99

glutamicum

GB_PAT：E08649 188 E08649 DNA encoding part of aspartase from coryneform bacteria. Corynebacterium 100,000 29-Sep-97

glutamicurmrxa02195 393 GB_BA2：AF086704 264 AF086704 Corynebacteriurn glutamicum phosphoribosyl-ATP-pyrophosphohydrolase Corynebacterium100,000 8-Feb-99

(hisE) gene，complete cds. glutamicum

GB_BA1：EAY17145 6019 Y17145 Eubacterium acidaminophilum grdR，grdI，grdH genes and partial ldc，grdT Eubacterium 39,075 5-Aug-98

genes. acidaminophllum

GB_STS：G01195 332 G01195 fruit fly STS Dm1930 clone DS06959 T7. Drosophila melanogaster 35,542 28-Feb-95rxa02197 551 GB_BA1：MTCY261 27322 Z97559 Mycobacterium tuberculosis H37Rv complete genome；segment 95/162. Mycobacterium 33,938 17-Jun-98

tuberculosis

GB_BA1：MLCB2533 40245 AL035310 Mycobacterium leprae cosmid B2533. Mycobacterium leprae 65,517 27-Aug-99

GB_BA1：U00017 42157 U00017 Mycobacterium leprae cosmid B2126. Mycobacterium leprae 36,770 01-MAR-

1994rxa02198 2599 GB_BA1：U00017 42157 U00017 Mycobacterium teprae cosmid B2126. Mycobacterium leprae 38,674 01-MAR-

1994

GB_BA1：MLCB2533 40245 AL035310 Mycobacterium leprae cosmid B2533. Mycobacterium leprae 65,465 27-Aug-99

GB_BA1：MTCY261 27322 Z97559 Mycobacterium tuberculosis H37Rv complete genome；segment 95/162. Mycobacterium 37,577 17-Jun-98

tuberculosisrxa02208 1025 GB_BA1：U00017 42157 U00017 Mycobacterium teprae cosmid B2126 Mycobacterium leprae 59,823 01-MAR-

1994

GB_BA1：AP000063 185300 AP000063 Aeropyrum pemix genomic DNA，section 6/7. Aeropyrum pernix 39,442 22-Jun-99

Table 4 (continuation)

GB_PR4：AC006236 127593 AC006236 Homo sapiens chromosome 17，clone hCIT.162_E_12，complete sequence. Homo sapiens 37,191 29-DEC-

1998rxa02229 948 GB_BA1：MSGY154 40221 AD000002 Mycobacterium tuberculosis sequence from cloney154. Mycobacterium 53,541 03-DEC-

tuberculosis 1996

GB_BA1：MTCY154 13935 Z98209 Mycobacterium tuberculosis H37Rv complete genome；segment 121/162. Mycobacterium 40,407 17-Jun-98

tuberculosis

GB_BA1：U00019 36033 U00019 Mycobacterium leprae cosmid B2235. Mycobacterium leprae 40,541 01-MAR-

1994rxa02234 3462 GB_BA1：MSGB937C 38914 L78820 Mycobacterium leprae cosmid B937 DNA sequence. Mycobacterium leprae 66,027 15-Jun-96

S

GB_BA1：MTCY2B12 20431 Z81011 Mycobacterium tuberculosis H37Rv complete genome；segment 61/162. Mycobaderium 71,723 18-Jun-98

tuberculosis

GB_BA2：U01072 4393 U01072 Mycobacterium bovis BCG orotidine-5′-monophosphate decarboxylase (uraA) Mycobacterium bovis 67,101 22-DEC-

gene. 1993rxa02235 727 GB_BA1：MSU91572 960 U91572 Mycobacterium smegmatis carbamoyl phosphate synthetase (pyrAB) gene. Mycobacterium smegmatis 60,870 22-MAR-

partial cds and orotidine 5′-monophosphate decarboxylase (pyrF) gene， 1997

complete cds.

GB_HTG3：AC009364 192791 AC009364 Homo sapiens chromosome 7，^***SEQUENCING IN PROGRESS^***，57 Homo sapiens 37,994 1-Sep-99

unordered pieces.

GB_HTG3：AC009364 192791 AC009364 Homo sapiens chromosome 7，^***SEQUENCING IN PROGRESS^***，57 Homo sapiens 37,994 1-Sep-99

unordered pieces.rxa02237 693 GB_BA1：MTCY21B4 39150 Z60108 Mycobacterium tuberculosis H37Rv complete genome；segment 62/162. Mycobacterium 55,844 23-Jun-98

tuberculosis

GB_BA2：AF077324 5228 AF077324 Rhodococcus equi strain 103 plasmid RE-VP1 fragment f. Rhodococcus equi 41,185 5-Nov-98

GB_EST22：AU017763 586 AU017763 AU017763 Mousa two-cell stage embryo cDNA Mus musculus cDNA clone Mus musculus 38,616 19-OCT-

J0744A04 3′，mRNA sequence. 1998rxa02239 1389 GB_BA1：MTCY21B4 39150 Z80108 Mycobecterium tuberculosis H37Rv complete genome；segment 62/162. Mycobacterium 56,282 23-Jun-98

tuberculosis

GB_HTG3：AC0t0745 193862 AC010745 Homo sapiens clone NH0549D18，^***SEQUENCING IN PROGRESS^***，30 Homo sapiens 36,772 21-Sep-99

unordered pieces.

GB_HTG3：AC010745 193862 AC010745 Homo sapiens clore NH0549D18，^***SEQUENCING IN PROGRESS^***，30 Homo sapiens 36,772 21-Sep-99

unordered pieces.rxa02240 1344 EM_PAT：E09855 1239 E09855 gDNA encoding S-adenosylmethionine synthetase. Conynebacterium 99,515 07-OCT-

glutamicum 1997(Rel

52，Created)

GB_PAT：A37831 5392 A37831 Sequence 1 from Patent WO9408014. Streptomyces 63,568 05-MAR-

pristinaespiralis 1997

GB_BA2：AF117274 2303 AF117274 Streptomyces spectabilis flavoprotein homolog Dfp (dfp) gene，partial cds；and Streptomyces spectabilis 65,000 31-MAR-

S-adenosylmethionine synthetase (metK) gene，complete cds. 1999rxa02246 1107 EM_BA1：AB003693 5589 AB003693 Corynebacterium ammoniagenes DNA for rib operon，complete cds. Corynebacterium 52,909 03-OCT-

ammoniagenes 1997(Rel.

52，Created)

Table 4 (continuation)

GB_PAT：E07957 5589 E07957 gDNA encoding at least guanosine triphosphate cyclohydrolase and riboflavin Corynebacterium 52,909 29-Sep-97

synthase. ammoniagenes

GB_PAT：I32742 5589 I32742 Sequence 1 from patent US 5589355. Unknown. 52,909 6-Feb-97rxa02247 756 GB_PAT：I32743 2689 I32743 Sequence 2 from patent US 5589355. Unknown. 57,937 6-Feb-97

EM_BA1：AB003693 5589 AB003693 Corynebacterium ammoniagenes DNA for rib operon，complete cds. Corynebacteriurm 57,937 03-OCT-

ammoniagenes 1997(Rel.

52，Created)

GB_PAT：I32742 5589 I32742 Sequence 1 from patent US 5589355. Unknown. 57，937 6-Feb-97rxa02248 1389 GB_PAT：I32742 5589 I32742 Sequence 1 from patent US 5589355. Unknown. 61,843 6-Feb-97

EM_BA1：AB003693 5589 AB003693 Corynebacterium ammoniagenes DNA for rib operon，complete cds. Corynebacterium 61,843 03-OCT-

ammoniagenes 1997(Rel.

52，Created)

GB_PAT：E07957 5589 E07957 gDNA encoding at least guanosine triphosphate cyclohydrolase and niboflavin Corynebacterium 61,843 29-Sep-97

synthase. ammoniagenesrxa02249 600 GB_PAT：E07957 5589 E07957 gDNA encoding at least guanosine triphosphate cyclohydrotase and riboflavin Corynebacterium 64,346 29-Sep-97

synthase. ammoniagenes

GB_PAT：I32742 5589 I32742 Sequence 1 from patent US 5589355. Unknown. 64,346 6-Feb-97

GB_PAT：I32743 2689 I32743 Sequence 2 from patent US 5589355. Unknown. 64,346 6-Feb-97rxa02250 643 GB_PAT：E07957 5589 E07957 gDNA encoding at least guanosine triphosphate cyclohydrolase and riboflavin Corynebacterium 56,318 29-Sep-97

synthase. ammoniagenes

GB_PAT：I32742 5589I32742 Sequence 1 from patent US 5589355. Unknown. 56,318 6-Feb-97

EM_BA1：AB003693 5589 AB003693 Corynebacterium ammoniagenes DNA for rib operon，complete cds. Corynebacterium 56,318 03-OCT-

ammoniagenes 1997(Rel.

52，Created)rxa02262 1269 GB_BA1：CGL007732 4460 AJ007732 Corynebacterium glutamicum 3′ppc gene，secG gene，amt gene，ocd gene Corynebacterium 100,000 7-Jan-99

and 5′soxA gene. glutamicum

GB_BA1：CGAMTGEN 2028 X93513 C.glutamicum amt gene. Corynebacterium 100,000 29-MAY-

E glutamicum 1996

GB_VI：HEHCMVCG 229354 X17403 Human cytomegalovirus strain AD169 complete genome. human herpesvirus 5 38,651 10-Feb-99rxa02263 485 GB_BA1：CGL007732 4460 AJ007732 Corynebacterium glutamicum 3′ppc gene，secG gene，arnt gene，ocd gene Corynebacterium 100,000 7-Jan-99

and 5′soxA gene. glutamicum

GB_BA1：CGL007732 4460 AJ007732 Corynebacterium glutamicum 3′ppc gene，secG gene，arnt gene，ocd gene Corynebacterium 37,526 7-Jan-99

and 5′soxA gene. glutamicumrxa02272 1368 EM_PAT：E09373 1591 E09373 Creatinine deiminase gene. Bacillus sp. 96,928 08-OCT-

1997(Rel.

52，Created)

GB_BA1：D38505 1591 D38505 Bacillus sp. gene for creatinine deaminase，complete cds. Bacilus sp. 96,781 7-Aug-98

GB_HTG2：AC006595 146070 AC006595 Homo sapiens，^***SEQUENCING IN PROGRESS^***，4 unordered pieces. Homo sapiens 36,264 20-Feb-99rxa02281 1545 GB_GSS12：AQ41101 551 AQ411010 HS_2257_B1_H02_MR CIT Approved Human Genomic Sperm Library D Homo sapiens 36,197 17-MAR-

0 Homo sapiens genomic clone Plate＝2257 Col＝3 Row＝P，genomic survey 1999

sequence.

Table 4 (continuation)

GB_EST23：AI128623 363 AI128623 qa62c01.s1 Soares_fetal_heart_NbHH19W Homo sapiens cDNA clone Homo sapiens 37,017 05-OCT-

IMAGE：1691328 3′，mRNA sequence. 1998

GB_PL2：ATAC007019 102335 AC007019 Arabidopsis thaliana chromosome II BAC F7D8 genomic sequence，complete Arabidopsis thaliana 33,988 16-MAR-

sequence. 1999rxa02299 531 GB_BA2：AF116184 540 AF116184 Corynebacterium glutamicum L-aspartate-alpha-decarboxytase precursor Corynebacterium 100,000 02-MAY-

(panD) gene，complete cds. glutamicum 1999

GB_GSS9：AQ164310 507 AQ164310 HS_2171_A2_E01_MR CIT Approved Human Genomic Sperm Library D Homo sapiens 37,278 16-OCT-

Homo sapiens genomic clone Plate＝2171 Col＝2 Row＝l，genomic survey 1998

sequence.

GB_VI：MH68TKH 4557 X93468 Murine herpesvirus type 68 thymidine kinase and glycoprotein H genes， murine herpesvirus 68 40,288 3-Sep-96rxa02311 813 GB_HTG4：AC006091 176878 AC006091 Drosophila melanogaster chromosome 3 clone BACR48G05(D475)RPCI-98 Drosophila melanogaster36,454 27-OCT-

48.G.5 map 91F1-91F13 strain y；cn bw sp，^***SEQUENCING IN 1999

PROGRESS^***，4 unordered pieces.

GB_HTG4：AC006091 176878 AC006091 Drosophila melanogaster chromosome 3 clone BACR48G05 (D475) RPCI-98 Drosophila melanogaster36,454 27-OCT-

48.G.5 map 91F1-91F13 strain y；cn bw sp，^***SEQUENCING IN 1999

PROGRESS^***，4 unordered pieces.

GB_BA2：RRU65510 16259 U65510 Rhodospirillum rubrum CO-induced hydrogenase operon (cooM.cooK，cooL， Rhodospirillum rubrum 37,828 9-Apr-97

cooX，cooU，cooH) genes，iron sulfur protein (cooF) gene，carboln monoxide

dehydrogenase (cooS) gene，carbon monoxide dehydrogesase

accessory proteins (cooC，cooT，cooJ) genes，putative transcriptional actlvator

(cooA) gene，nicotinate-nucleotide pyrophosphorylase (nadC) gene，complete

cds，L-aspartate oxidase (nadB) gene，and alkyl hydroperoxide

reductase (ahpC) gene，partial cds.rxa02315 1752 GB_BA1：MSGY224 40051 AD000004 Mycobacterium tuberculosis sequence from clone y224. Mycobacterium 49,418 03-DEC-

tuberculosis 1996

GB_BA1：MTY25D10 40838 Z95558 Mycobacterium tuberculosis H37Rv complete genome；segment 28/162. Mycobacterium 49,360 17-Jun-98

tuberculosis

GB_BA1：MSGY224 40051 AD000004 Mycobacterium tuberculosis sequence from clone y224. Mycobacterium 38,150 03-DEC-

tuberculosis 1996rxa02318 402 GB_HTG3：AC011348 111083 AC011348 Homo sapiens chromosome 5 clone ClT-HSPC_303E13，^***SEQUENCING Homo sapiens 35,821 06-OCT-

IN PROGRESS^***，3 ordered pieces. 1999

GB_HTG3：AC011348 111083 AC011348 Homo sapiens chromosome 5 clone ClT-HSPC_303E13，^***SEQUENCING Homo sapiens 35,821 06-OCT-

IN PROGRESS^***，3 ordered pieces. 1999

GB_HTG3：AC011412 89234 AC011412 Homo sapiens chromosome 5 clone ClT978SKB_81K21.^***SEQUENCING Homo sapiens 36,181 06-OCT-

IN PROGRESS^***，3 ordered pieces. 1999rxa02319 1080 GB_BA1：MSGY224 40051 AD000004 Mycobacterium tuberculosis sequence from clone y224. Mycobacterium 37,792 03-DEC-

tuberculosis 1996

GB_BA1：MTY25D10 40838 Z95558 Mycobacterium tuberculosis H37Rv complete genome；segment 28/162. Mycobacterium 37,792 17-Jun-98

tuberculosis

GB_EST23：AI117213 476 AI117213 ub83h02.r1 Soares 2NbMT Mus musculus cDNA clone IMAGE：1395123 Mus muscutus 35,084 2-Sep-98

5′，mRNA sequence.

Table 4 (continuation) rxa 023451320 GB _ BA 1: BAPURKE 2582X 91189B. ammoniagenes purK and purE genes. Corynebacterium 61,73114-Jan-97

ammoliagenes

GB_BA1：MTCY71 42729 Z92771 Mycobacterium tuberculosis H37Rv complete genome；segment 141/162. Mycobacterium 39,624 10-Feb-99

tuberculosis

GB_BA1：MTCY71 42729 Z92771 Mycobacterium tuberculosis H37Rv complete genome；segment 141/162. Mycobacterium 39,847 10-Feb-99

tuberculosisrxa02350 618 GB_BA1：BAPURKE 2582 X91189 B.ammoniagenes purK and purE genes. Corynebacterium 64,286 14-Jan-97

ammoniagenes

GB_PL1：SC130KBXV 129528 X94335 S.cerevisiae 130kb DNA fragment from chromosome XV. Saccharomyces cerevisiae36,617 15-Jul-97

GB_PL1：SCXVORFS 50984 X90518 S.cerevisiae DNA of 51 Kb from chromosome XV right arm. Saccharomyces cerevisiae36,617 1-Nov-95rxa02373 1038 GB_PAT：E00311 1853 E00311 DNA coding of 2，5-diketogluconic acid reductase. unidentified 56,123 29-Sap-97

GB_PAT：I06030 1853 I06030 Sequence 4 from Patent EP 0305608. Unknown. 56,220 02-DEC-

1994

GB_PAT：I00836 1853 100836 Sequence 1 from Patent US 4758514. Unknown. 56,220 21-MAY-

1993rxa02375 1350 GB_BA2：CGU31230 3005 U31230 Corynebacterium glutamnicum Obg protein homolog gene，partial cds，gamma Corynebacterium 99,332 2-Aug-96

glutamyl kinase (proB) gene，complete cds，and (unkdh) gene，complete cds， glutamicum

GB_HTG3：AC009946 169072 AC009946 Homo sapiens clone NH0012C17，^***SEQUENCING IN PROGRESS^***，1 Homo sapiens 36,115 8-Sep-99

unordered pieces.

GB_HTG3：AC009946 169072 AC009946 Homo sapiens clone NH0012C17，^***SEQUENCING IN PROGRESS^***，1 Homo sapiens 36,115 8-Sep-99

unordered pieces.rxa02380 777 GB_BA1：MTCY253 41230 Z81368 Mycobacterium tuberculosis H37Rv complete genome；segment 106/162. Mycobacterium 38,088 17-Jun-98

tuberculosis

GB_HTG4：AC010658 120754 AC010658 Drosophila meianogaster chromosome 3L/75C1 clone RPCI98-3B20，^***Drosophila melanogaster 35,817 16-OCT-

SEQUENCING IN PROGRESS^***，78 unordered pieces. 1999

GB_HTG4：AC010658 120754 AC010658 Drosophila melanogaster chromosome 3L/75C1 clone RPCI98-3B20，^***Drosophila melanogaster 35,817 16-OCT-

SEQUENCING IN PROGRESS^***，78 unordered pieces. 1999rxa02382 1419 GB_BA1：CGPROAGE 1783 X82929 C.glutamicum proA gene. Corynebacterium 98,802 23-Jan-97

N glutamicum

GB_BA1：MTCY428 26914 Z81451 Mycobacterium tuberculosis H37Rv complete genome；segment 107/162. Mycobacterium 38,054 17-Jun-98

tuberculosis

GB_BA2：CGU31230 3005 U31230 Corynebacteriumn glutamicum Obg protein homolog gene，partial cds，gamma Corynebacterium 98,529 2-Aug-96

glutamyl kinase (proB) gene，complete cd5，and (unkdh) gene，complete cds. glutamicumrxa02400 693 GB_BA1：CGACEA 2427 X75504 C.glutamicum aceA gene and thiX genes (partial). Corynebacterium 100,000 9-Sep-94

glutamicum

GB_PAT：I86191 2135 I86191 Sequence 3 from patent US 5700661. Unknown. 100,000 10-Jun-98

GB_PAT：I13693 2135 I13693 Sequence 3 from patent US 5439822. Unknown. 100,000 26-Sep-95rxa02432 1098 GB_GSS15：AQ60684 574 AQ606842 HS_5404_B2_E07_T7A RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens39,716 10-Jun-99

2 genomic clone Plate＝980 Col＝14 Row＝J.genomic survey sequence.

Table 4 (continuation)

GB_EST1：T05804 406 T05804 EST03693 Fetal brain，Stratagene (cat#936206) Homo sapiens cDNA clone Homo sapiens 37,915 30-Jun-93

HFBDG63 similar to EST containing Alu repeat，mRNA sequence.

GB_PL1：AB006699 77363 AB006699 Arabidopsis thaliana genomic DNA，chromosome 5，P1 clone：MD J22， Arabidopsis thaliana 35,526 20-Nov-99

complete sequence.rxa02458 1413 GB_BA2：AF114233 1852 AFl14233 Corynebacterium glutamicum 5-enolpyruvyulshikimate 3-phosphate synthase Corynebacterium 100,000 7-Feb-99

(sroA) gene，complete cds. glutamicum

GB_EST37：AW01306 578 AW013061 ODT-0033 Winter flounder ovary pieuronectes amnericanus cDNA clone ODT- Pleuronectes americanus 39,175 10-Sep-99

1 0033 5′similar to FRUCTOSE-BISPHOSPHATE ALDOLASE B (LIVER)，

mRNA sequence.

GB_GSS15：AQ65002 728 AQ650027 Sheared DNA-5L2.TF Sheared DNA Trypanosoma brucei genomic clone Trypanosoma brucei 39,281 22-Jun-99

7 Sheared DNA-5L2，genomic survey sequence.rxa02469 1554 GB_BA1：MTCY359 36021 Z83859 Mycobacterium tuberculosis H37Rv complete genome；segment 84/162. Mycobacterium 39,634 17-Jun-98

tuberculosis

GB_BA1：MLCB1768 39228 AL006609 Mycobacterium teprae cosmid B1788. Mycobacterium leprae 59,343 27-Aug-99

GB_BA1：SCAJ10601 4692 AJ010601 Streptomyces coslicolor A3(2) DNA for whiD and whiK loci. Streptomyces coelicolor 48,899 17-Sep-98rxa02497 1050 GB_BA2：CGU31224 422 U31224 Conynebacterium glutamicum (ppx) gene，partial cds. Corynebacterium 96,445 2-Aug-96

glutandcum

GB_BA1：MTCY20G9 37218 Z77162 Mycobacterium tuberculosis H37Rv complete genome；segment 25/162. Mycobacterium 59,429 17-Jun-98

tuberculosis

GB_BA1：SCE7 16911 AL049819 Streptomyces coelicolor cosmid E7. Streptomyces coelicolor 39,510 10-MAY-

1999rxa02499 933 GB_BA2：CGU31225 1817 U31225 Corynebacterium glutamicum L-proline：NADP+ 5-oxidoreductase (proC) gene，Corynebacterium 97,749 2-Au9-96

complete cds. glutamicum

GB_BA1：NG17PILA 1920 X13965 Neisseria gonorrhoeae pitA gene. Neisseria gonorrhoeae 43,249 30-Sep-93

GB_HTG2：AC007984 129715 AC007984 Drosophila melanogaster chromosome 3 clone BACR05C10 (D781) RPC1-98 Drosophila melanogaster 33,406 2-Aug-99

05.C.10 map 97D-97E strain y；cn bw sp，^***SEQUENCING IN PROG RESS

^***，87 unordered pieces.rxa02501 1188 GB_BA1：MTCY20G9 37218 Z77162 Mycobacterium tuberculosis H37Rv complete genome；segment 25/162. Mycobacterium 39,357 17-Jun-98

tuberculosis

GB_BA1：U00018 42991 U00018 Mycobacterium leprae cosmid B2168. Mycobacterium leprae 51,768 01-MAR-

1994

GB_VI：HE 1CG152261 X14112 Herpes simplex virus (HSV) type 1 complete genome. human herpesvirus 1 39,378 17-Aor-97rxa02503 522 GB_PR3：AC005328 35414 AC005328 Homo sapiens chromosome 19，cosmid R26660，complete sequence. Homo sapiens 39,922 28-Jul-98

GB_PR3：AC005545 43514 AC005545 Homo sapiens chromosome 19，cosmid R26634，complete sequence. Homo sapiens 39,922 3-Sep-98

GB_PR3：AC005328 35414 AC005328 Homo sapiens chromosome 19，cosmid R26660，complete sequence. Homo sapiens 34,911 28-Jul-98rxa02504 681 GB_BA1：MTCY20G9 37218 Z77162 Mycobacterium tuberculosis H37Rv complete genome；segment 25/162. Mycobacterium 54,940 17-Jun-98

tuberculosis

GB_PR3：AC005328 35414 AC005328 Homo sapiens chromosome 19，cosmid R26660，complete sequence. Homo sapiens 41,265 28-Jul-98

GB_PR3：AC005545 43514 AC005545 Homo sapiens chromosome 19，cosmid R26634，complete sequence. Homo sapiens 41,265 3-Sep-98rxa02516 1386 GB_BA1：MLCL536 36224 Z99125 Mycobacterium leprae cosmid L536. Mycobacterium leprae 37,723 04-DEC-

1998

GB_BA1：U00013 35881 U00013 Mycobacterium leprae cosmid B1496. Mycobacterium leprae 37,723 01-MAR-

1994

Table 4 (continuation)

GB_BA1：MTV007 32806 AL021184 Mycobacterium tuberculosis H37Rv complete genome；segment 64/162. Mycobacterium 61,335 17-Jun-98

tuberculosisrxa02517 570 GB_BA1：MLCL536 36224 Z99125 Mycobacterium leprae cosmid L536. Mycobacterium leprae 37,018 04-DEC-

1998

GB_BA1：U00013 35881 U00013 Mycobacterium leprae cosmid B1496. Mycobacterium leprae 37,018 01-MAR-

1994

GB_BA1：SCC22 22115 AL096839 Streptomyces coelicolor cosmid C22. Streptomyces coelicolor37,071 12-Jul-99rxa02532 1170G6_OV：AF137219 831 AF137219 Amia calva mixed lineage leukemia-like protein (MII) gene，pantial cds. Amia calve 36,853 7-Sep-99

GB_EST30：AI645057 301 AI645057 vs52a10.y1 Stratagene mouse Tcell 937311 Mus rnusculus cDNA clone Mus musculus 41,860 29-Apr-99

IMAGE：1149882 5′，mRNA sequence.

GB_EST20：AA822595 429 AA822595 vs52a10.r1 Stratagene mouse Tcell 937311 Mus musculus cDNA clone Mus musculus 42,353 17-Feb-98

IMAGE：1149882 5′，mRNA sequence.rxa02536 879 GB_HTG2：AF130866 118874 AF130866 Homo sapiens chromosome 8 clone PAC 172N13 map 8q24，^***Homo sapiens 40,754 21-MAR-

SEQUENCING IN PROGRESS^***，in unordered pieoss. 1999

GB_HTG2：F130866 118874 AF130866 Homo sapiens chromosome 8 clone PAC 172N13 map 8q24，^***Homo sapiens 40,754 21 -MAR-

SEQUENCING IN PROGRESS^***，in unordered pieces. 1999

GB_PL1：ATT12J5 84499 AL035522 Arabidopsis thaliara DNA chromosome 4，BAC clone T12J5 (ESSAII project). Arabidopsis thaliana 35,063 24-Feb-99rxa02550 1434 GB_BA1：MTCY279 9150 Z97991 Mycobacterium tuberculosis H37Rv complete genome；segment 17/162. Mycobactedum 37,773 17-Jun-98

tuberculosis

GB_BA1：MSGB1970C 39399 L78815 Mycobacterium leprae cosmid B1970 DNA sequence. Mycobacterium leprae 39,024 15-Jun-96

S

GB_BA2：SC2H4 25970 AL031514 Streptomyces coelicolor cosmid 2H4. Streptomyces coelicolor37,906 19-OCT-

A3(2) 1999rxa02559 1026 GB_BA1：MTV004 69350 AL009198 Mycobacterium tuberculosis H37Rv complete genome；segment 144/162. Mycobecterium 47,358 18-Jun-98

tuberculosis

GB_PAT：I28684 5100 I28684 Sequence 1 from patent US 5573915. Unknown. 39,138 6-Feb-97

GB_BA1：MTU27357 5100 U27357 Mycobacterium tuberculosis cycloprcpane mycolic acid synthase (cma1) Mycobacterium 39,138 26-Sep-95

gene，complete cds. tubercuiosisrxa02622 1683 GB_BA2：AE001780 11997 AE001780 Thermotoga maritima section 92 of 136 of the complete genome. Thermotoga martima 44,914 2-Jun-99

GB_OV：AF064564 49254 AF064564 Fugu rubripes neurofibromatosis type 1 (NF1)，A-kinase anchor protein Fugu rubripes 39,732 17-Aug-99

(AKAP84)，BAW protein (BAW)，and WSB1 protein (WSB1) genes，complete

cds.

GB_OV：AF064564 49254 AF064564 Fugu rubripes neurofibromatosis type 1 (NF1)，A-kinase anchor protein Fugu rubripes 36,703 17-Aug-99

(AKAP84)，BAW protein (BAW)，and WSB1 protein (WSB1) genes，complete

cds.rxa02623 714 GB_GSS5：AQ818728 444 AQ818728 HS_5268_A1_G09_SP6E RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 38,801 26-Aug-99

genomic clone Plate＝844 Col＝17 Row＝M，genomic survey sequence.

GB_HTG5：ACO11083 198586 AC011083 Homo sapiens chromosome 9 clone RP11-111M7 map 9，WORKING DRAFT Homo sapiens 35,714 19-Nov-99

SEQUENCE，51 unordered pieces.

GB_GSS6：AQ826948 544 AQ826948 HS_5014_A2_C12_T7A RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 39,146 27-Aug-99

genomic clone Plate＝590 Col＝24 Row＝E，genomic survey sequence.

Table 4 (continuation) rxa 02629708 GB _ VI: BRSMGP 462M 86652 bone respiratory synthetic virus membrane mRNA, complete bone respiratory synthetic 37,01328-Apr-93

ods. virus

GB_VI：BRSMGP 462 M86652 Bovine respiratory syncytial virus membrane glycoprotein mRNA， complete Bovine respiratory syncytial 37,013 28-Apr-93

cds. virusrxa02645 1953 GB_PAT：A45577 1925 A45577 Sequence 1 from Patent WO9519442. Corynebacterium 39,130 07-MAR-

glutamieum 1997

GB_PAT：A45581 1925 A45581 Sequence 5 from Patent WO9519442. Corynebacterium 39,130 07-MAR-

glutamicum 1997

GB_BA1：CORILVA 1925 L01508 Corynebacterium glutamicum threonine dehydratase (ilvA) gene，complete Corynebacterium 39,13026-Apr-93

cds. glutamicumrxa02646 1392 GB_BA1：CORILVA 1925 L01508 Corynebacterium glutamicum threonine dehydratase (ilvA) gene，complete Corynebacterium 99,138 26-Apr-93

cds. glutamicum

GB_PAT：A45585 1925 A45585 Sequence 9 from Patent WO9519442. Corynebacterium 99,066 07-MAR-

glutamicum 1997

GB_PAT：A45583 1925 A45583 Sequence 7 from Patent WO9519442. Corynebacterium 99,066 07-MAR-

glutamicum 1997rxa02648 1326 GB_OV：ICTCNC 2049 M83111 Ictalurus punctatus cyclic nucleotide-gated channel RNA sequence. Ictalurus punctatus 38,402 24-MAY-

1993

GB_EST11：AA265464 345 AA265464 mx91c06.r1 Soares mouse NML Mus musculus cDNA clone IMAGE：693706 Mus musculus 38,655 20-MAR-

5′，mRNA sequence. 1997

GB_GSS8：AQ006950 480 AQ006950 CIT-HSP-2294E14.TR CIT-HSP Homo sapiens genomic clone 2294E14， Homo sapiens 36,074 27-Jun-98

genomic survey sequence.rxa02653rxa02687 1068 GB_BA1：CORPHEA 1088 M13774 C.glutamicum pheA gene encoding prephenate dehydratase，complete cds. Corynebacterium 99,715 26-Apr-93

glutamicum

GB_PAT：E04483 948 E04483 DNA encoding prephenate dehydratase. Corynebacterium 98,523 29-Sep-97

glutamicum

GB_PAT：E06110 948 E06110 DNA encoding prephenate dehydratase. Corynebacterium 98,523 29-Sep-97

glutamicumrxa02717 1005 GB_PL1：HVCH4H 59748 Y14573 Hordeum vulgare DNA for chromosome 4H. Hondeum vulgare 36,593 25-MAR-

1999

GB_PR2：HS310H5 29718 Z69705 Human DNA sequence from cosnid 310H5 from a contig from the tip of the Homo sapiens 36,089 22-Nov-99

short arm of chromosome 16，spanning 2Mb of 16p13.3.Contains EST and

CpG island.

GB_PR3：AC004754 39188 AC004754 Homo sapiens chromosome 16，cosmid done RT286 (LANL)，complete Homo sapiens 36,089 28-MAY-

sequence. 1998rxa02754 1461 GB_HTG2：AC008223 130212 AC008223 Drosophila melanogaster chromosome 3 clone BACR16118 (D815) RPCl-98 Drosophila melanogaster 32,757 2-Aug-99

16.1.18 map 95A-95A strain y；cn bw sp，^***SEQUENCING IN

PROGRESS^***，101 unordered pieces.

Table 4 (continuation)

GB_HTG2：AC008223 130212 AC008223 Drosophila melanogaster chromosome 3 clone BACR16118 (D815) RPCI-98 Drosophila melanogaster 32,757 2-Aug-99

161.18 map 95A-95A strain y；cn bw sp，^***SEQUENCING IN PROGRESS

^***，101 unordered pieces.

GB_BA1：MTCY71 42729 792771 Mycobacterium tuberculosis H37Rv comptete genome；segment 141/162. Mycobacterium 37,838 10-Feb-99

tuberculosisrxa02758 1422 GB_HTG5：5C011678 171967 AC011678 Homo sapiens clone 14_B_7，^***SEQUENCING IN PROGRESS^***，20 Homo sapiens 35,331 5-Nov-99

unordered pieces.

GB_HTG5：AC011678 171967 AC011678 Homo sapiens clone 14_B_7，^***SEQUENCING IN PROGRESS^***，20 Homo sapiens 33,807 5-Nov-99

unordered pieces.

GB_BA2：AF064070 23183 AF064070 Burkholderia pseudomallei putative dibydroorotase (pyrC) gene，partial cds； Burkholderia pseudomallei 36,929 20-Jan-99

putative 1-acyl-sn-glycerol-3-phosphate acyltransferase (plsC)，putative

diadenosine tetraphosphatase (apaH)，complete cds；type II O-antigen

biosynthesis gene duster，complete sequence；putative undecaprenyl

phosphate N-acetytglucosaminyttransferase，and putative UDP-glucose 4-

epimerase genes，complete cds；and putative galactosyl transferase gene，

partial cds.rxa02771 678 GB_BA2：AF038651 4077 AF038651 Corynebacterium glutamicum dipeptide-binding protein (dciAE) gene，partial Corynebacterium 99,852 14-Sep-98

cds；adenine phosphoribosyltransferase (apt) and GTP pyrophosphokinase glutamicum

(rel) genes，complete cds；and unknown gene.

GB_IN1：CELT19B4 37121 U80438 Caenorhabditis elegans cosmid T19B4. Caenorhabditis elegans 43,836 04-DEC-

1996

GB_EST36：AV193572 360 AV193572 AV193572 Yuji Kohara unpublished cDNA：Strain N2 hermaphrodite embryo Caenorhabditis elegans 48,588 22-Jul-99

Caenorhaditis elegans cDNA clone yk618h8 5′，mRNA sequence.rxa02772 1158 GB_BA2：AF038651 4077 AF038651 Corynebacterium glutamicum dlpeptide-binding protein (dciAE) gene，partial Corynebacterium 99,914 14-Sep-98

cds；adenine phosphoribosyttransferase (apt) and GTP pyrophosphokinase glutamicum

(rel) genes，complete cds；and unknown gene.

GB_BA1：MTCY227 35946 Z77724 Mycobacterium tuberculosis H37Rv complete genome；segment 114/162. Mycobacterium 38,339 17-Jun-98

tuberculosis

GB_BA1：U00011 40429 U00011 Mycobacterium leprae cosmid B1177. Mycobacterium leprae 38,996 01-MAR-

1994rxa02790 1266 GB_BA1：MTCY159 33818 Z83863 Mycobacterium tuberculosis H37Rv complete genome；segment 111/162. Mycobacterium 37,640 17-Jun-98

tuberculosis

GB_PR4：AC006581 172931 AC006581 Homo sapiens 12p21 BAC RPCI11-259O18 (Roswell Park Cancer Institute Homo sapiens 37,906 3-Jun-99

Human BAC Library) complete sequence.

GB_PR4：AC006581 172931 AC006581 Homo sapiens 12p21 BAC RPCI11-259O18 (Roswell Park Cancer Institute Homo sapiens 35,280 3-Jun-99

Human BAC Library) complete sequence.rxa02791 951 GB_BA1：MTCY159 33818 Z83863 Mycobacterium tubercuiosis H37Rv comptete genome；segment 111/162. Mycobacterium 39,765 17-Jun-98

tuberculosis

GB_OV：CHKCEK2 3694 M35195 Chicken tyrosine kinase (cek2) mRNA，complete cds. Gallus gallus 38,937 28-Apr-93

GB_BA1：MSASDASK 5037 Z17372 M.smegmatis asd，ask-alpha，and ask-beta genes. Mycobacterium smegmatis 38,495 9-Aug-94

rxa02802 1194 GB_EST24：Al223401 169 AI223401 qg48g01.x1 Soares_testis_NHT Homo sapiens cDNA clone IMAGE：1838448 Homo sapiens 40,828 27-OCT-

3′similar to WP：C25D7.8 CE08394；，mRNA sequence. 1998

Table 4 (continuation)

GB_EST24：AI223401 169 AI223401 qg48g01.x1 Soares_testis_NHT Homo sapiens cDNA clone IMAGE：1838448 Homo sapiens 40,828 27-OCT-

3′similar to WP；C25D7.8 CE08394；，mRNA sequence. 1998rxa02814 494 GB_BA1：MTCY7D11 22070 Z95120 Mycobacterium tuberculosis H37Rv complete genome；segment 138/162. Mycobacterium 58,418 17-Jun-98

tuberculosis

GB_BA1 ：MTCY7D11 22070 Z95120 Mycobacterium tuberculosis H37Rv compfete genome；segment 138/162. Mycobacterium 40,496 17-Jun-98

tuberculosis

GB_PR1：HSAJ2962 778 AJ002962 Homo sapiens mRNA for hB-FABP. Homo sapiens 39,826 8-Jan-98rxa02843 608 GB_BA1：CGAJ4934 1160 AJ004934 Corynebacterium glutamicum dapD gene，complete CDS. Corynebacterium 100,000 17-Jun-98

glutamicum

GB_BA1 ：MTCI364 29540 Z93777 Mycobacterium tuberculosis H37Rv complete genome；segment 52/162. Mycobacterium 37,710 17-Jun-98

tuberculosis

GB_BA1：MLU15180 38675 U15180 Mycobacterium leprae cosmid B1756. Mycobacterium leprae 39,626 09-MAR-

1995rxs03205 963 GB_BA1：BLSIGBGN 2906 Z49824 B.lactofermentum orf1 gene and sigB gene. Corynebacterium glutamicur 88,854 25-Apr-96

GB_EST21：AA980237 377 AA980237 ua32a12.r1 Soares_mammary_gland_NbMMG Mus musculus cDNA clone Mus musculus 41,489 27-MAY-

IMAGE：13484145′similar to TR：Q61025 Q61025 HYPOTHETICAL 15.2 KD 1998

PROTEIN.；，mRNA sequence.

GB_EST23：AI158516 371 AI158316 ud27c05.r1 Soares_thymus_2NbMT Mus musculus cDNA clone Mus musculus 38,005 30-Sep-98

IMAGE：1447112 5′，mRNA sequence.rxs03223 1237 GB_IN1：LMFL2743 38368 AL031910 Leishrnania major Friedlin chromosome 4 cosmid L2743. Leishmania major 39,869 15-DEC-

1999

GB_PR3：HSDJ61B2 119666 AL096710 Human DNA sequence from clone RP1-61B2 on chromosome 6p11.2-12.3 Homo sapiens 34,930 17-DEC-

Contains isoforms 1 and 3 of BPAG1 (bullous pemphigoid antigen 1 1999

(230/240kD)，an exon of a gene similar to murine MACF cytoskeletal protein，

STSs and GSSs，completa sequence.

GB_PR3：HSDJ61B2 119666 AL096710 Human DNA sequence from clone RP1-61B2 on chromosome 6p11.2-12.3 Homo sapiens 34,634 17-DEC-

Contains isoforms 1 and 3 of BPAG1 (bullous pemphigoid antigen 1 1999

(230/240kD)，an exon of a gene similar to murine MACF cytoskeletal protein.

STSs and GSSs. complete sequence.

Examples

Example 1: preparation of Corynebacterium glutamicum ATCC13032 Total genomic DNA

A culture of Corynebacterium glutamicum (ATCC 13032) was cultured overnight in BHI medium (Difco) with vigorous shaking at 30 ℃. The cells were collected by centrifugation, the supernatant discarded and the cells resuspended in 5ml of buffer I (5% of the original culture volume-all volumes indicated are calculated for 100ml of culture volume). Composition of buffer I: 140.34g/l sucrose, 2.46g/l sucrose ×7 ，10ml/l The solution (100g/l, adjusted to pH6.7), 50g/l M12 concentrate (10 g/l) ，1g/l ，2g/l ×7 ，0.2g/l 0.5g/l yeast extract (Difco)), 10ml/l mixture of trace elements (200 mg/l) × ，10mg/l ×7 ，3mg/l ×4 ，30mg/l ，20mg/l ×6 ，1mg/l ×6 ，3mg/l ×2 ) 500mg/l complexing agent (EDTA or citric acid), 100ml/l vitamin mixture (0.2mg/l biotin, 0.2mg/l folic acid, 20mg/l p-aminobenzoic acid, 20mg/l riboflavin, 40mg/l panthothenate, 140mg/l nicotinic acid, 40mg/l pyridoxal hydrochloride, 200mg/l inositol). Lysozyme was added to the suspension to a final concentration of 2.5 mg/ml. After incubation at37 ℃ for about 4 hours, the cell walls were degraded and the resulting protoplasts were collected by centrifugation. The precipitate was washed once with 5ml of buffer I and once with 5ml of TE buffer (10 mM) 1ml EDTA, pH8) was washed once. The pellet was resuspended in 4ml of TE buffer and 0.5ml of SDS solution (10%) and 0.5ml were added Solution (5M). Proteinase K was added to a final concentration of 200g/ml and the suspension was incubated at 37 ℃ for about 18 hours. DNA was purified by extraction with phenol, phenol-chloroform-isoamyl alcohol, chloroform-isoamyl alcohol according to standard procedures. Then, 1/50 volumes of 3M sodium acetate and 2 volumes of ethanol were added and incubated at-20 ℃ for 30 minThe DNA was precipitated by centrifugation at 12,000rpm for 30 minutes using a high speed centrifuge using SS34 rotor (Sorvall). The DNA was dissolved in 1ml of TE buffer containing 20g/ml RNaseA and dialyzed at 4 ℃ for at least 3 hours in 1000ml of TE buffer. During this time, the buffer was changed 3 times. 0.4ml of 2M was added per 0.4ml of dialyzed DNA solution And 0.8ml ethanol. After incubation at-20 ℃ for 30 min, DNA was collected by centrifugation (13,000rpm, Biofuge Freeco, Heraeus, Hanau, Germany). The DNA pellet was dissolved in TE buffer. The DNA prepared according to this procedure can be used for all purposes, including southern hybridization and construction of genomic libraries.

Example 2: construction of genomic library of Corynebacterium glutamicum ATCC13032 in Escherichia coli

Cosmid libraries and plasmid libraries can be constructed using DNA prepared as described in example 1, according to known and well established methods (see, e.g., Sambrook, J.et al (1989) "Molecular Cloning: organic Manual" Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, or Ausubel, F.M.et al (1994) "Current Protocols in Molecular biology", John Wiley&Sons.).

Any plasmid and cosmid may be used. Plasmid pBR322(Sutcliffe, J.G. (1979) Proc. Natl. Acad. Sci. USA, 75: 3737-; pACYl77(Change&Cohen (1978) J. bacteriol 134: 1141-1156), pBS series plasmids (pBSSK +, pBSSK-and others; Stratagene, LaJolla, USA), cosmid SuperCosl (Stratagene, LaJolla, USA) or Lorist6(Gibson, T.J., Rosenthal A. and Waterson, R.H. (1987) Gene 53: 283-286) can be used for special purposes. A gene library exclusively used in Corynebacterium glutamicum can be constructed using the plasmid pSLl09(Lee, H. -S.and A.J.Sinskey (1994) J.Microbiol.Biotechnol.4: 256-263).

Example 3: DNA sequencing and computer functional analysis

DNA Sequencing can be carried out according to standard methods using genomic libraries as described in example 2, in particular using the chain termination method using an ABI377 sequencer (see, e.g., Fleischman, R.D.et al (1995) "batch-genome Random Sequencing and analysis of Haemophilus Influenzae Rd., Science, 269: 496-512). Sequencing primers having the following nucleotide sequences were used: 5'-GGAAACAGTATGACCATG-3' or 5'-GTAAAACGACGGCCAGT-3'.

Example 4: in vivo mutagenesis

In vivo mutagenesis of C.glutamicum may be performed by passage of plasmid (or other vector) DNA from E.coli or other microorganisms (e.g.certain species of Bacillus or yeasts such as Saccharomyces cerevisiae) whose ability to maintain the integrity of their genetic information has been impaired. Typical mutants have mutations in the genes of the DNA repair system (e.g., mutHLS, mutD, mutT, etc.; references to Rupp, W.D (1996) DNA repaires, in: Escherichia coli and Salmonella, p.2277-2294, ASM: Washington.). These strains are well known to the skilled person. The use of these strains is described, for example, in Greener, a.and Callahan, m. (1994) Strategies 7: 32-34.

Example 5: DNA transferred between E.coli and C.glutamicum

Corynebacterium and Brevibacterium species contain endogenous plasmids that replicate spontaneously (such as, for example, pHM1519 or pBL1) (see, e.g., Martin, J.F.et al (1987) Biotechnology, 5: 137-. The shuttle vectors for E.coli and C.glutamicum can be readily constructed using standard vectors for E.coli (Sambrook, J.et al (1989) "Molecular Cloning: A Laboratory Manual" Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press or Ausubel, F.M.et al (1994) "Current Protocols in Molecular Cloning", John Wiley&Sons.), i.e.the replication fork initiation of C.glutamicum and the appropriate marker are added thereto. Such origins of replication are preferably obtained from endogenous plasmids isolated from Corynebacterium and Brevibacterium species. Particular use as transformation markers for these species are kanamycin resistance Genes (such as those From the Tn5 or Tn903 transposons) or chloramphenicol resistance Genes (Winnacker, E.L, (1987) "From Genes to Clones-Introduction to Gene technology, VCH, Weinheim). There are many examples in the literature of the construction of various wild-type shuttle vectors which can be replicated in E.coli and C.glutamicum and which can be used for various purposes, including Gene overexpression (see, for example, Yoshihama, M.et al (1985) J.Bacteriol.162: 591-597, Martin J.F.et al (1987) Biotechnology, 5: 137-146 and Eikmanns, B.J.et a; (1991) Gene, 102: 93-98).

The gene of interest can be cloned into the shuttle vector described above using standard methods, and the hybrid vector can be introduced into a strain of C.glutamicum. Transformation of C.glutamicum can be effected by protoplast transformation (Kastsumata, R.et al (1984) J.Bacteriol.159306-311), electroporation (Liebl, E.et al (1989) FEMS Microbiol.letters, 53: 399-. Shuttle vectors can also be transferred from C.glutamicum to E.coli by preparing plasmid DNA from C.glutamicum (using standard methods known in the art) and transforming it into E.coli. This transformation step can be carried out using standard methods, but it is advantageous to use Mcr-deficient E.coli strains, for example NM522(Gough&Murray (1983) J.mol.biol.166: 1-19).

Overexpression of the gene in C.glutamicum was possible using plasmids containing pCG1(U.S. patent No.4,617,267) or fragments thereof, and selecting the kanamycin resistance gene from TN903 (Gridley, N.D. and Joyce, C.M. (1980) Proc.Vatl.Acad.Sci.USA 77 (12): 7176-7180). In addition, genes can also be overexpressed in C.glutamicum using plasmid pSL109(Lee, H. -S.and A.J.Sinskey (1994) J.Microbiol.Biotechnol.4: 256-263).

In addition to the use of replicable plasmids, overexpression of genes can also be achieved by genomic integration. Genomic integration of C.glutamicum or other Corynebacterium or Brevibacterium species can be achieved by well-known methods, such as homologous recombination of genomic regions, restriction endonuclease-mediated integration (REMI) (see, for example, DE Patent 19823834), or by using transposons. The activity of a gene of interest can also be modulated by modifying regulatory regions (e.g., promoters, repressors, and/or enhancers), by sequence modification, insertion, or deletion using site-directed methods (e.g., homologous recombination) or random event-based methods (e.g., transposon mutagenesis or REMI). Nucleic acid sequences which function as transcription terminators may also be inserted 3' of the coding region of one or more genes of the present invention; such terminators are well known in the art and are described, for example, in Winnacker, E.L, (1987) From Genes to Clones-Introduction to Gene technology, VCH: weinheim.

Example 6: estimation of mutein expression

The observation of the activity of the mutant protein in the transformed host cell relies on the fact that the mutant protein is expressed in a similar manner and in similar amounts as the wild-type protein. One useful method of determining the level of transcription of a mutant gene (an indicator of the amount of mRNA used for translation of the gene product) is by Northern hybridization (see, e.g., Ausubel et al (1988) Current Protocols in Molecular Biology, Wiley: New York) in which primers designed to bind the gene of interest are labeled with a detectable label (usually radioactive or chemiluminescent), such that, when all of the RNA of an organism culture is extracted, run on gel electrophoresis, transferred to a stabilizing medium and incubated with the probe, the binding and amount of the binding probe indicates the presence and amount of mRNA from the gene. This information is evidence of the extent of transcription of the mutated gene. Several methods can be used to prepare total cellular RNA from c.glutamicum, which is well known in the art, for example as described in Bormann, e.r.et al (1992) mol.microbiol.6: 317 and 326.

To estimate the presence and relative amount of protein translated from this mRNA, standard techniques can be used, such as Wesstern hybridization (see, e.g., Ausubel et al (1988) Current protocols in Molecular Biology, Wiley: New York). In this method, whole cellular proteins are extracted, separated by gel electrophoresis, transferred to a medium such as nitrocellulose, and incubated with a probe, such as an antibody, that specifically binds to the desired protein. The probes are typically labeled with a chemiluminescent or colorimetric label for ease of detection. The presence and amount of the observed marker indicates the presence and amount of the desired mutein present in the cell.

Example 7: growth medium and cultureconditions for genetically modified corynebacterium glutamicum

Genetically modified corynebacterium glutamicum may be cultured in synthetic or natural growth media. Various growth media for C.glutamicum are known and readily available (Lieb, et al (1989) appl. Microbiol. Biotechnology, 32: 205-;liebl (1992) "The Genus Corynebacterium, in: procaryotes, Volume II, Balows, a.et al, eds. These media contain one or more carbon sources, nitrogen sources, inorganic salts, vitamins and trace elements. Preferred carbon sources are sugars, such as mono-, di-or polysaccharides. For example, glucose, fructose, mannose, galactose, ribose, sorbose, ribulose, lactose, maltose, sucrose, raffinose, starch or cellulose can be used as a good carbon source. Sugars, such as molasses or other by-products of sugar refining, may also be provided to the medium by complex compounds. It may also be advantageous to increase the mixture of different carbon sources. Other carbon sources that may be used are alcohols and organic acids such as methanol, ethanol, acetic acid or lactic acid. Nitrogen sources are generally organic or inorganic nitrogen compounds, or substances containing these compounds. Representative nitrogen sources include ammonia or ammonium salts, e.g. Or 、 Nitrate, nitrate,Urea, amino acids or complex nitrogen sources such as corn steep liquor, soybean meal, soy protein, yeast extract, meat extract or others.

Inorganic salt compounds which may be included in the medium include calcium, magnesium, sodium, cobalt, molybdenum, potassium, manganese, zinc, copper or iron as hydrochlorides, phosphates or sulfates. Chelating agents may be added to the medium to maintain the metal ions in solution. Particularly useful chelating agents includedihydroxyphenols, such as catechol and protocatechuic acid, or organic acids, such as citric acid. The medium typically also contains growth factors such as vitamins and growth promoters, examples of which include biotin, riboflavin, thiamine, folic acid, nicotinic acid, pantothenate and pyridol. Growth factors and salts are often derived from complex media components such as yeast extract, molasses, corn steep liquor and other components. The exact composition of the medium compounds is strongly dependent on direct experiments and is specifically determined for each specific case. Information on the optimization of the medium is given in the textbook "applied Microbiol. physiology, A Practical Approach" (eds. P.M.Rhodes, P.F.Stanbury, IRL Press (1997) pp.53-73, ISBN 0199635773). Growth media may also be selected from commercial suppliers, such as standard 1(Merck) or BHI (grain heart infusion, DIFCO) or others.

All media components were sterilized by heating (1.5bar, 120 ℃, 20 minutes) or sterile filtration. The components may be sterilized together or, if necessary, separately. All media components may be added at the beginning of growth, or alternatively continuously or in portions.

Culture conditions were determined for each experiment separately. The temperature should be in the range of 15 ℃ to 45 ℃. The temperature may be kept constant or varied during the experiment. The pH of the medium is in the range of 5 to 8.5, preferably at about 7.0, and can be maintained by the addition of a buffer to the medium. A typical buffer for this purpose is potassium phosphate buffer. Synthetic buffers such as MOPS, HEPES, ACES and others may be used instead of or in addition to the buffers.Or by adding during the growth process Or To maintain stable cultureThe pH value. If complex media components like yeast extracts are used, the necessity of adding buffers can be reduced due to the fact that many complex compounds have a strong buffering capacity. If a fermenter is used to grow the microorganisms, ammonia gas may also be used to control the pH.

The incubation time is typically in the range of a few hours to a few days. This time is chosen to allow the maximum amount of product to accumulate in the liquid medium. The growth experiments disclosed may be carried out in various vessels, such as microtiter plates, glass test tubes, glass shake flasks or fermenters of different sizes of glass or metal. To screen large numbers of clones, the microorganisms should be cultured in microtiter plates, glass test tubes or shake flasks with or without baffles. Preferably, a 100ml shake flask is used, to which 10% by volume of the desired medium is added. The flask should be shaken on a shaker (amplitude 25 mm) at a speed in the range of 100 and 300 rpm. Evaporation losses can be reduced by keeping the air moist; alternatively, the evaporation loss is corrected mathematically.

If genetically modified clones are to be detected, unmodified control clones or control clones containing the basic plasmid without any inserts should also be detected. Cells grown on agar plates incubated at 30 ℃ are used, e.g.CM plates (10g/l glucose, 2.5g/l 2g/l urea, 10g/l polypeptone, 5g/l yeast extract, 5g/l meat extract, 22g/l agar, 2M Adjusted to pH6.8), the medium was inoculated to OD₆₀₀The value is 0.5-1.5. Inoculation of the medium can be achieved by introducing a salt suspension of C.glutamicum cells from CM plates, or by adding a liquid preculture of this bacterium.

Example 8: in vitro analysis of mutein function

The activity of the enzyme andthedetermination of kinetic parameters is well established in the art. Any assay for determining the activity of a given altered enzyme must be adapted to the specific activity of the wild-type enzyme and is well within the ability of the skilled person. General comments about enzymes, as well as explicit details about structure, kinetics, principles, methods, applications and determination of many examples of enzymatic activities, can be found, for example, in the following references: dixon, m., and Webb, e.c. (1979) EnzymesLongmans: london; fersht, (1985) Enzyme Structure and Mechanism, Freeman: new York; walsh, (1979) Enzymatic Reaction mechanisms, freeman: SanFrancisco; price, n.c., Stevens, l. (1982) Fundamentals of enzymology.oxforduniv.press: oxford; boyer, P.D., ed. (1983) The Enzymes, 3^rded.Academic Press：New York；Bisswanger，H.，(1994)Enzymkinetik，2^nded.VCH：Weinheim(ISBN3527300325)；Bergmeyer，H.U.，Bergmeyer，J.，Graβl，M.，eds.(1983-1986)Methods of Enzymatic Analysis，3^rded.，vol.I-XII，Verlag Chemie：Weinheim；andUllmann’s Encyclopedia of Industrial Chemistry(1987)vol.A9，“Enzymes”.VCH：Weinheim，p.352-363。

The activity of a protein that binds to DNA can be determined by several methods known in the art, such as a DNA band shift assay (also known as a gel retardation assay). The effect of these proteins on the expression of other molecules can be determined using reporter gene assays (e.g., as described in Kolmar, H.et al (1995) EMBO J.14: 3895-3904, and references cited therein). Reporter assay systems are known and established for use in both prokaryotic and eukaryotic cells, using enzymes such as beta-galactosidase, green fluorescent protein and several other proteins.

The activity of membrane transport proteins can be determined, for example, as described in Gennis, R.B (1989) "ports, Channels and Transporters", in biomebrane, MolecularStructure and Function, Springer: heidelberg, p.85-137; 199->234; and 270, 322.

Example 9: analysis of the Effect of the mutant proteins on the production of the desired product

The effect of a genetic modification of C.glutamicum on the production of a desired compound (e.g.an amino acid) can be estimated by growing the modified microorganism under suitable conditions (e.g.those described above) and analysing the medium and/or cell components which increase the production of the desired product (e.g.an amino acid). These analytical Techniques are well known to the skilled person and include spectroscopic analysis, thin-layer chromatography, various staining methods, enzymatic methods and microbiological methods, and are, for example, high performance liquid chromatography (Ullman, Encyclopedia of Industrial Chemistry, vol. A2, p.89-90 and p.443-613, VCH: Weinheim (1985); Fallon, A.et al. (1987) "Applications of HPLC in Biochemistry" in Laboratory technologies in Biochemistry and Molecular Biology, vol.17; Rehm et al (1993) Biotechnology, vol.3, channel III: "production and purification", page 469-714, VCH: Weinheim, Beer, P.A.8. 1988. and Biotechnology, John, plant 35J.1988. and 5. Biochemical and company, Inc.; 5. and 5. C.7. environmental Chemistry and biological, and 2.5. environmental Chemistry, and 2. J., page 1-27, VCH: weinheim; and Deshow, F.J (1989) Separation and purification techniques in biotechnology, Noyes Publications).

In addition to the determination of the final fermentation product, other components of the metabolic pathway for the production of the desired compound, such as intermediates and by-products, can also be analyzed to determine the overall efficiency of production of the compound. Analytical methods include the determination of nutrient levels (e.g., sugars, hydrocarbons, nitrogen sources, phosphate and other ions) in the culture medium, the determination of biomass composition and growth, the analysis of the production of common metabolites of biosynthetic pathways, and the determination of gas production in the fermentation. Standard methods for these assays are outlined in Applied microbiological biology, a Practical Approach, p.m. rhodes and p.f. stanbury, eds., IRL Press, p.103-163; and 165-192 (ISBN: 0199635773) and the references cited therein.

Example 10: purification of the desired product from cultures of Corynebacterium glutamicum

The recovery of the desired product from the cells of Corynebacterium glutamicum or from the supernatant of the above-mentioned medium can be carried out by various methods known in the art. If the desired product is not secreted by the cells, the cells can be harvested from the culture medium by low speed centrifugation and lysed by standard techniques, such as mechanical force or sonication. Cell debris was removed by centrifugation and the supernatant fraction containing soluble proteins was retained for further purification of the desired compound. If the product is secreted from C.glutamicum cells, the cells are removed from the medium by low-speed centrifugation, and the supernatant fraction is retained for further purification.

The supernatant fraction from any one of the purification methods is subjected to chromatography on a suitable resin, and the desired molecule is retained by the chromatography resin while many impurities in the sample are not retained, or the impurities are retained by the resin while the sample is not retained. This chromatography step can be repeated as desired using the same or different chromatography resins. The selection of suitable chromatography resins is well within the skill of the art and the most effective use of these resins for the particular molecule to be purified is well known. The purified product may be concentrated by filtration or ultrafiltration and stored at a temperature at which product stability is greatest.

There are a great many purification methods known in the art, and the aforementioned purification methods are not meant to be limited thereto. These purification methods are described, for example, in Bailey, j.e.&Ollis, d.f. biochemical Engineering Fundamentals, McGraw-Hill: new York (1986).

The identity and purity of the isolated compound can be estimated by standard techniques in the art. This includes High Performance Liquid Chromatography (HPLC), spectroscopic methods, staining methods, thin layer chromatography, NIRS, enzymatic methods or microbiological methods. These analytical methods are reviewed in the following documents: patek et al (1994) appl.environ.microbiol.60: 133-140; malakhova et al (1996) Biotek technology iya 11: 27-32; and Schmidt et al (1998) Bioprocess Engineer.19: ullmann's Encyclopedia of Industrial Chemistry, (1996) vol.A27, VCH: weinheim, p.89-90, p.521-540, p.540-547, p.559-566, 575-; michal, G. (1999) Biochemical Pathways: an Atlas of Biochemistry and molecular Biology, John Wiley and Sons; fallon, A.et al (1987) Applications of HPLC in Biochemistry in: laboratory Techniques in Biochemistry and molecular biology, vol.17.

Example 11: analysis of the Gene sequence of the present invention

Sequence comparison and determination of percent homology between two sequences is a technique known in the art and can be accomplished using mathematical algorithms, such as Karlin and Altschul (1990) proc.natl.acad.sci.usa 87: 2264-68, described by Karlin and Altschul (1993) Proc.Natl.Acad.Sci.USA 90: 5873-77 there are modifications. This algorithm is incorporated in Altschul, et al (1990) j.mol.biol.215: NBLAST and XBLAST programs (version 2.0) in 403-10. BLAST nucleotide searches can be performed using the NBLAST program, score 100, wotdlength 12, and can result in nucleotide sequences homologous to the MP nucleic acid molecules of the invention. BLAST protein searches can be performed using the XBLAST program, score 50, and wordlength 3, to obtain amino acid sequences homologous to the MP protein molecules of the present invention. For comparison purposes, to obtain gapped alignments, the sequences described in Altschul et al, (1997) Nucleic Acids Res.25 (17): 3389 Gapped BLAST in 3402. When using BLAST and Gapped BLAST programs, one skilled in the art knows how to optimize the parameters of the programs (e.g., XBLAST and NBLAST) for a particular sequence to be analyzed.

Another example of a mathematical algorithm for sequence comparison is the Meyers and Miller algorithms ((1998) Compout. appl. biosci.4: 11-17). This algorithm is incorporated into the ALIGN program (version 2.0), which is part of the GCG sequence alignment software package. When comparing amino acid sequences using the ALIGN program, a PAM120 weight residue table, gap Length penalty of 12, and gap penalty of 4 can be used. Other sequencing algorithms are also known in the art, including ADVANCE and ADAM, described in Torelli and Robotti (1994) Compout.Appl.biosci.10: 3-5; and FASTA, described in Pearson and lipman (1998) p.n.a.s.85: 2444-8.

The percent homology between two amino acid sequences can also be achieved using the GAP program in the GCG software package (http:// www.gcg.com available), using Blosum 62 or PAM 250 matrices, GAP components 12, 10, 8,6 or 4, and length components 2, 3 or 4. The percent homology between two nucleic acid sequences can be achieved using the GAP program in the GCG software package, using standard parameters, such as GAP component 50 and length component 3.

Comparative Analysis between the gene sequences of the invention and those in Genbank can be performed using techniques known in the art (see, e.g., Bexevanis and Ouellette, eds. (1998) Bioinformatics:A Practical Guide to the Analysis of Genes and proteins John Wiley and Sons: New York). The gene sequence of the invention is compared with the sequence in Genbank by a three-step method. In the first step, BLASTN analysis (e.g., local sequence alignment analysis) is performed on each of the sequences of the present invention against nucleotide sequences in Genbank, retaining the top 500 matches for further analysis. These 500 matches are then subjected to a FASTA search (e.g., local versus world-wide combinatorial alignment analysis in which defined sequence regions are aligned). Next, for each gene sequence of the invention, the three highest matches to FASTA, a worldwide alignment was performed using the GAP program (using standard parameters) in the GCG software package. To obtain correct results, the length of the sequence selected from Genbank is adjusted to the length of the query sequence using methods well known in the art. The results of this analysis are listed in table 4. Although the results thus obtained are consistent with the results obtained from a single GAP (worldwide) analysis of each gene of the invention relative to each Genbank control, the computational time required is greatly reduced relative to GAP (worldwide) analysis of large databases. Sequences of the invention that did not get alignments above the cut-off value, lack alignment information, as shown in table 4. One skilled in the art will appreciate further that the percent GAP alignment homology under the heading "% homology (gpa)", listed in table 4, is listed in european numeric format, where ',' stands for decimal point. For example, the value "40,345" in this column represents "40.345%".

Example 12: construction and manipulation of DNA microarrays

The sequences of the invention may also be used for the construction and application of DNA microarrays (the design, methods and uses of DNA arrays are well known in the art and are described, for example, in Schena, M.te., et al (1995) Science 270: 467-.

DNA microarrays use solid or flexible supports, including nitrocellulose, nylon, glass, silicon, or other materials. The nucleic acid molecules may be attached to the surface in an ordered manner. After suitable labeling, other nucleic acids or mixtures of nucleic acids can be hybridized to the immobilized nucleic acid molecules, and the labels can be used to monitor and measure the individual signal intensities of the hybridizing molecules of a defined region. The present method allows for the simultaneous quantification of the relative or absolute amount of all or selected nucleic acids in a suitable nucleic acid sample or mixture. Thus, DNA microarrays allow for the analysis of expression of a variety (up to 6800 or more) of similar nucleic acids (see, e.g., Schena, M. (1996) BioEssays 18 (5): 427-.

The sequences of the invention can be used to design oligonucleotide primers that can amplify a defined region of one or more genes of Corynebacterium glutamicum by a nucleic acid amplification reaction, such as the polymerase chain reaction. The selection and design of the 5 'or 3' oligonucleotide primers or suitable linkers allows the resulting PCR products to be covalently attached to the surface of the support medium described above (also described, for example, in Schena, M.et al. (1995) Science 270: 467-.

Nucleic acid microarrays can also be prepared by methods such as those described in Widiaka, L.et al (1997) AatureBiotechnology 15: 1359-1367 by in situ oligonucleotide synthesis. By the photolithographic method, precisely defined areas of the matrix can be exposed to light. The protecting group is photolabile, being activated and undergoing nucleotide addition, but the region masked from light is not modified at all. Subsequent cycles of protection and photoactivation allow the synthesis of different oligonucleotides at defined positions.The defined small regions of the invention can be synthesized on microarrays by solid phase oligonucleotide synthesis.

Nucleic acid molecules of the invention, present in a sample or a mixture of nucleotides, can be hybridized to a microarray. These nucleic acid molecules can be labeled according to standard methods. Briefly, a nucleic acid molecule (e.g., an mRNA molecule or a DNA molecule) may be labeled by binding to an isotope or a fluorescently labeled nucleotide, for example, in reverse transcription or DNA synthesis. Hybridization of labeled nucleic acids to microarrays is described (e.g., in Schena, M.et al. (1995) supra; Wodicka, L.et al (1997), supra; and DeSaizieu A.et al (1998), supra). Detection and quantification of the hybrid molecule is tailored to the specific binding label. Radioactive labels can be detected, for example, as described in Schena, m.et al (1995) supra, and fluorescent labels can also be detected, for example, using shamon et al (1996) Gemone Research 6: 639-.

As mentioned above, the use of the sequences according to the invention in DNA microarrays allows for comparative analysis of different strains of C.glutamicum or other coryneform bacteria. For example, by nucleic acid array methods, it is possible to facilitate the study of alterations within strains based on individual transcription profiles, as well as to facilitate the identification of genes that are important for specific and/or desired strain properties, such as pathogenicity, productivity and stress tolerance. Similarly, using nucleic acid array technology, partial maps of gene expression of the invention during fermentation reactions can also be compared.

Example 13: analysis of cell protein population dynamics (proteomics)

The genes, compositions and methods of the invention can be used to study the interactions and kinetics of protein populations, referred to as "proteomics". The protein populations of interest include, but are not limited to, the entire protein population of Corynebacterium glutamicum (e.g., as compared to protein populations of other organisms), those proteins that are active under particular environmental or metabolic conditions (e.g., in fermentation, at high or low temperatures, or at high or low pH), or those proteins that are active at particular stages of growth or development.

Protein populations can be analyzed by a variety of well-known techniques, such as gel electrophoresis. Cellular proteins can be obtained, for example, by lysis or extraction, and can also be separated from each other using various electrophoretic techniques. Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) separates proteins, largely based on their molecular weight. Isoelectric focusing polyacrylamide gel electrophoresis (IEF-PAGE) separates proteins by isoelectric focusing, which reflects not only the amino acid sequence but also shows post-translational modifications of the protein. Another more preferred method of protein analysis is a sequential combination of IEF-PAGE and SDS-PAGE, referred to as 2-D-gel Electrophoresis (described in, e.g., Hermann et al (1998) Electrophoresis 19: 3217-3221; Foutoulakis et al (1998) Electrophoresis 19: 1193-1202; Langen et al (1997) Electrophoresis 18: 1184-1192; Antelmann et al (1997) Electrophoresis 18: 1451-1463).

Proteins isolated by these methods can be visualized by standard techniques, e.g., by staining or labeling. Suitable stains are known in the art and include Coomassie Brilliant blue, silver stains or fluorescent dyes, such as Sypro Ruby (Molecular Probes). The culture medium of Corynebacterium glutamicum contains radiolabeled amino acids or other protein precursors (for example³⁵(ii) an amino acid selected from the group consisting of S-methionine,³⁵(ii) an S-cysteine residue, wherein the S-cysteine residue is,¹⁴c-a labeled amino acid, wherein the amino acid is,¹⁵an N-amino acid, wherein the amino acid is, or Or¹³C-labelled amino acids) can be such thatThese cells label the protein prior to its isolation. Similarly, fluorescent labels may also be used. These marker proteins can be extracted, isolated and separated according to the techniques described previously.

Proteins visualized by these techniques can be further analyzed by measuring the dye or label used. The amount of a particular protein can be determined quantitatively using, for example, optical methods, and can be compared to the amount of other proteins on the same gel or on other gels. The proteins on the gel can be compared by, for example, optical comparison, spectroscopic analysis, gel image analysis and scanning, or by using photographic film or a display. These techniques are well known in the art.

To determine the identity of a particular protein, direct sequencing or other standard techniques may be used. For example, N-and/or C-terminal amino acid sequencing (e.g., Edman degradation), as well as mass spectrometry (particularly MALDI or ESI techniques (see, e.g., Langen et al (1997) Electrophoresis 18: 1184-. The protein sequences provided herein can be used for the identification of C.glutamicum proteins by these techniques.

The information obtained by these techniques can be used to compare various patterns of modification between different samples under different biological conditions (e.g., different organisms, fermentation time points, culture conditions, or biological environments among other conditions) in the presence of proteins, activities, or biological environments. The data obtained from these tests can be used alone or in combination with other techniques for various applications, for example to compare the behaviour of various organisms in specific situations, for example metabolic situations, to increase the productivity of strains producing fine chemicals or to increase the efficiency of fine chemical production.

Statement of equivalence

Those skilled in the art will recognize, or be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments of the invention described herein. It is intended that the following claims contain such equivalents.

Sequence listing<110>BASF corporation (BASF Aktiengesellschaft)<120>Corynebacterium glutamicum gene encoding a metabolic pathway protein<130>BGI-121CPPC<140>PCT/00IB/00923<141>2000-06-23<150>US 60/141,031<151>1999-06-25<150>US 60/142,101<151>1999-07-02<150>US 60/148,613<151>1999-08-12<150>US 60/187,970<151>2000-03-09<150>DE 19930476.9<151>1999-07-01<150>DE 19931415.2<1999-07-08<150>DE 19931418.7<151>1999-07-08<150>DE 19931419.5<151>1999-07-08<150>DE 19931420.9<151>1999-07-08<150>DE 19931424.1<1999-07-08<151>1999-07-08<150>DE 36151>1999-07-08<150>DE 19931424.1<151>1999<150>DE 19931428.4<151>1999-07-08<150>DE 19931434.9<151>1999-07-08<150>DE 19931435.7<151>1999-07-08<150>DE 19931443.8<151>1999-07-08<150>DE 19931453.5<151>1999-07-08<150>DE 19931457.8<151>1999-07-08<150>DE 19931465.9<151>1999-07-08<150>DE 19931478.0<151>1999-07-08<150>DE 19931510.8<151>1999-07-08<150>DE 19931541.8<1999-07-08<150>DE 19931573.6<151>1999-07-08<150>DE 19931592.2<151>1999-07-08<150>DE 19931632.5<151>1999-07-08<150>DE 19931634.1<1999-07-08<150>DE 19931636.8<151>1999-151<150>1999-07-08<151>DE 38151>1999-08<151>1999-07-151<150>DE 1999-07-08<150>DE 19932125.6<151>1999-07-09<150>DE 19932126.4<151>1999-07-09<150>DE 19932130.2<151>1999-07-09<150>DE 19932186.8<151>1999-07-09<150>DE 19932206.6<151>1999-07-09<150>DE 19932227.9<151>1999-07-09<150>DE 19932228.7<151>1999-07-09<150>DE 19932229.5<151>1999-07-09<150>DE 19932230.9<151>1999-07-09<150>DE 19932922.2<151>1999-07-14<150>DE 19932926.5<151>1999-07-14<150>DE 19932928.1<151>1999-07-14<150>19933004.2<151>1999-07-151>19933004.2<151>1999-07-14<150>DE 19933005.0<151>1999-07>14<150>DE 19933006.9<151>1999-07-14<150>DE 19940764.9<151>1999-08-27<150>DE 39 19940765.7<151>1999-08-27<150>DE 19940766.5<151>1999-08-27<150>DE 19940832.7<151>1999-08-27<150>DE 19941378.9<151>1999-08-31<150>DE 19941379.7<151>1999-08-31<150>DE 19941380.0<151>1999-08-31<150>DE 19941394.0<151>1999-08-31<150>DE 19941396.7<1999-08-31<150>DE 19942076.9<151>1999-09-03<150>DE 19942077.7<151>1999-09-03<150>1999-19942079.3<151>1999-09-03<150>DE 19942086.6<151>1999-09-03<150>1999-19942087.4<150>DE 19942087.4<150>1999-19942087.4<151>1999-09-03<150>DE 19942088.2<151>1999-09-03<150>DE 19942095.5<151>1999-09-03<150>DE 19942124.2<151>1999-09-03<150>DE 19942129.3<151>1999-09-03<160>1158<210>1<211>948<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<925>RXA02229<400>1gctggttcaa cagagaccac cgcgtgtcct gggtcgacgc ctctggcgat cccaccgcac 60aagccttgga gattttgggt ctacaatagc gagggtgaat ttg acc atc ccc ttt 115

Leu Thr Ile Pro Phe

1 5gcc aaa ggc cac gcc acc gaa aac gac ttc atc atc atc ccc gat gag 163Ala Lys Gly His Ala Thr Glu Asn Asp Phe Ile Ile Ile Pro Asp Glu

10 15 20gat gcg cgc cta gat tta act cca gaa atg gtg gtc acg ctg tgt gac 211Asp Ala Arg Leu Asp Leu Thr Pro Glu Met Val Val Thr Leu Cys Asp

25 30 35cgc cgc gcc ggg atc ggt gct gat ggt atc ctc cgc gtg gtt aaa gct 259Arg Arg Ala Gly Ile Gly Ala Asp Gly Ile Leu Arg Val Val Lys Ala

40 45 50gca gac gta gaa ggc tcc acg gtc gac cca tcg ctg tgg ttc atg gat 307Ala Asp Val Glu Gly Ser Thr Val Asp Pro Ser Leu Trp Phe Met Asp

55 60 65tac cgc aac gcc gat gga tct ttg gct gaa atg tgc ggc aat ggt gtg 355Tyr Arg Asn Ala Asp Gly Ser Leu Ala Glu Met Cys Gly Asn Gly Val 70 75 80 85cgc ctg ttc gcg cac tgg ctg tac tcc cgc ggt ctt gtt gat aat acg 403Arg Leu Phe Ala His Trp Leu Tyr Ser Arg Gly Leu Val Asp Asn Thr

90 95 100agc ttt gat atc ggt acc cgc gcc ggt gtc cgc cac gtt gat att ttg 451Ser Phe Asp Ile Gly Thr Arg Ala Gly Val Arg His Val Asp Ile Leu

105 110 115cag gca gat caa cat tct gcg cag gtc cgc gtt gat atg ggc ate cct 499GlnAla Asp Gln His Ser Ala Gln Val Arg Val Asp Met Gly Ile Pro

120 125 130gac gtc acg gga tta tcc acc tgc gac atc aac ggc caa gta ttc gct 547Asp Val Thr Gly Leu Ser Thr Cys Asp Ile Asn Gly Gln Val Phe Ala

135 140 145ggc ctt ggc gtt gat atg ggt aac cca cac cta gcg tgc gtt gtg ccg 595Gly Leu Gly Val Asp Met Gly Asn Pro His Leu Ala Cys Val Val Pro150 155 160 165ggc tta agt gcg tcg gct ctt gcc gat atg gaa ctg cgc gca cct acg 643Gly Leu Ser Ala Ser Ala Leu Ala Asp Met Glu Leu Arg Ala Pro Thr

170 175 180ttt gat cag gaa ttc ttc ccc cac ggt gtg aac gta gaa atc gtc aca 691Phe Asp Gln Glu Phe Phe Pro His Gly Val Asn Val Glu Ile Val Thr

185 190 195gaa tta gaa gat gac gca gta tcg atg cgc gtg tgg gaa cgc gga gtg 739Glu Leu Glu Asp Asp Ala Val Ser Met Arg Val Trp Glu Arg Gly Val

200 205 210ggc gaa acc cgc tcc tgt ggc acg gga acc gtt gct gca gcg tgt gct 787Gly Glu Thr Arg Ser Cys Gly Thr Gly Thr Val Ala Ala Ala Cys Ala

215 220 225gct tta gct gat gct gga ttg gga gaa ggc aca gct aaa gtg tgc gtt 835Ala Leu Ala Asp Ala Gly Leu Gly Glu Gly Thr Ala Lys Val Cys Val230 235 240 245cca cgt ggg gaa gta gaa gtc cag atc ttt gac gac ggc tcc aca ctc 883Pro Arg Gly Glu Val Glu Val Gln Ile Phe Asp Asp Gly Ser Thr Leu

250 255 260acc ggc cca agc gcc atc atc gca ctc ggt gag gtg cag atc 925Thr Gly Pro Ser Ala Ile Ile Ala Leu Gly Glu Val Gln Ile

265270275 taagattcgc gattgtagttcgg 948<210>2<211>275<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>2Leu Thr Ile Pro Phe Ala Lys Gly His Ala Thr Glu Asn Asp Phe Ile 151015 Ile Ile Pro Asp Glu Asp Ala Arg Leu Asp Leu Thr Pro Glu Met Val

20 25 30Val Thr Leu Cys Asp Arg Arg Ala Gly Ile Gly Ala Asp Gly Ile Leu

35 40 45Arg Val Val Lys Ala Ala Asp Val Glu Gly Ser Thr Val Asp Pro Ser

50 55 60Leu Trp Phe Met Asp Tyr Arg Asn Ala Asp Gly Ser Leu Ala Glu Met 65 70 75 80Cys Gly Asn Gly Val Arg Leu Phe Ala His Trp Leu Tyr Ser Arg Gly

85 90 95Leu Val Asp Asn Thr Ser Phe Asp Ile Gly Thr Arg Ala Gly Val Arg

100 105 110His Val Asp Ile Leu Gln Ala Asp Gln His Ser Ala Gln Val Arg Val

115 120 125Asp Met Gly Ile Pro Asp Val Thr Gly Leu Ser Thr Cys Asp Ile Asn

130 135 140Gly Gln Val Phe Ala Gly Leu Gly Val Asp Met Gly Asn Pro His Leu145 150 155 160Ala Cys Val Val Pro Gly Leu Ser Ala Ser Ala Leu Ala Asp Met Glu

165 170 175Leu Arg Ala Pro Thr Phe Asp Gln Glu Phe Phe Pro His Gly Val Asn

180 185 190Val Glu Ile Val Thr Glu Leu Glu Asp Asp Ala Val Ser Met Arg Val

195 200 205Trp Glu Arg Gly Val Gly Glu Thr Arg Ser Cys Gly Thr Gly Thr Val

210 215 220Ala Ala Ala Cys Ala Ala Leu Ala Asp Ala Gly Leu Gly Glu Gly Thr225 230 235 240Ala Lys Val Cys Val Pro Arg Gly Glu Val Glu Val Gln Ile Phe Asp

245 250 255Asp Gly Ser Thr Leu Thr Gly Pro Ser Ala Ile Ile Ala Leu Gly Glu

260 265 270Val Gln Ile

275<210>3<211>1491<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1468)<223>RXS02970<400>3aaccgacaaa acagccgttc acgtgctaaa gcagctcggc ttgatctagg gtgaggtgag 60ttatttaaag acttcataat attttgggga gtgaactggt ttg gca ttg aag ggt 115

Leu Ala Leu Lys Gly

1 5tac acc aac ttt gac ggt gaa ttc atc gaa ttc gga tct gtg caa gca 163Tyr Thr Asn Phe Asp Gly Glu Phe Ile Glu Phe Gly Ser Val Gln Ala

10 15 20aaa gaa gag gaa aaa cgg gca ttc gac aac gat cgc gcg cac gtt ttc 211Lys Glu Glu Glu Lys Arg Ala Phe Asp Asn Asp Arg Ala His Val Phe

25 30 35cac tcc tgg tcc gcg cag gac aaa atc agc ccc aaa gta tgg gca gct 259His Ser Trp Ser Ala Gln Asp Lys Ile Ser Pro Lys Val Trp Ala Ala

40 45 50gcc gaa ggt tcc acg ctg tac gac ttc gac ggc aac gcc ttc atc gac 307Ala Glu Gly Ser Thr Leu Tyr Asp Phe Asp Gly Asn Ala Phe Ile Asp

55 60 65atg ggt tcc caa ctt gtc tcg gca aac tta ggc cac aac aac cct cga 355Met Gly Ser Gln Leu Val Ser Ala Asn Leu Gly His Asn Asn Pro Arg 70 75 80 85tta gtt gag gcg atc cag cgc caa gca gcc cgg ttg acc aac atc aac 403Leu Val Glu Ala Ile Gln Arg Gln Ala Ala Arg Leu Thr Asn Ile Asn

90 95 100ccg gcc ttc ggc aat gat gtg cgc tct gat gtt gct gca aag atc gtg 451Pro Ala Phe Gly Asn Asp Val Arg Ser Asp Val Ala Ala Lys Ile Val

105 110 115tcg atg gcc cgt ggc gaa ttc tcc cac gtg ttt ttc acc aac ggc ggc 499Ser Met Ala Arg Gly Glu Phe Ser His Val Phe Phe Thr Asn Gly Gly

120 125 130gcc gac gcc atc gag cac tcc atc cgc atg gct cgc ctg cae acc gga 547Ala Asp Ala Ile Glu His Ser Ile Arg Met Ala Arg Leu His Thr Gly

135 140 145cgc aac aaa att ctg tcc gca tac cgc agc tac cac ggc gca acc gga 595Arg Asn Lys Ile Leu Ser Ala Tyr Arg Ser Tyr His Gly Ala Thr Gly150 155 160 165tcc gcg atg atg ctc acc ggc gaa cac cgc cgc ctg ggc aac ccc acc 643Ser Ala Mer Met Leu Thr Gly Glu His Arg Arg Leu Gly Asn Pro Thr

170 175 180acc gac cca gat atc tac cac ttc tgg gca cca ttc ctg cac cac tcc 691Thr Asp Pro Asp Ile Tyr His Phe Trp Ala Pro Phe Leu His His Ser

185 190 195tca ttc ttt gcc acc acc caa gaa gaa gaa tgc gaa cgc gca ctc aag 739Ser Phe Phe Ala Thr Thr Gln Glu Glu Glu Cys Glu Arg Ala Leu Lys

200 205 210cac ttg gaa gat gtc atc gcg ttt gaa ggt gct ggc atg atc gca gcg 787His Leu Glu Asp Val Ile Ala Phe Glu Gly Ala Gly Met Ile Ala Ala

215220 225atc gtc ctg gag cca gtg gtg gga tca tca gga atc atc ctg cca cca 835Ile Val Leu Glu Pro Val Val Gly Ser Ser Gly Ile Ile Leu Pro Pro230 235 240 245gca ggt tac tta aat ggc gtg cgc gaa ctt tgc aac aag cac ggc atc 883Ala Gly Tyr Leu Asn Gly Val Arg Glu Leu Cys Asn Lys His Gly Ile

250 255 260ctc ttc atc gcc gac gaa gtc atg gtc gga ttc gga cgc acc gga aaa 931Leu Phe Ile Ala Asp Glu Val Met Val Gly Phe Gly Arg Thr Gly Lys

265 270 275ctg ttt gct tac gag cat gct ggc gac gat ttc cag cca gac atg atc 979Leu Phe Ala Tyr Glu His Ala Gly Asp Asp Phe Gln Pro Asp Met Ile

280 285 290acc ttc gcc aag ggt gtt aac gca ggt tac gcc cca ctc ggt ggc atc 1027Thr Phe Ala Lys Gly Val Asn Ala Gly Tyr Ala Pro Leu Gly Gly Ile

295 300 305gtg atg acc caa tca atc cgc gat acc ttc gga tca gag gca tac tcc 1075Val Met Thr Gln Ser Ile Arg Asp Thr Phe Gly Ser Glu Ala Tyr Ser310 315 320 325ggc gga ctc acc tac tcc gga cac cca ctt gca gta gca ccc gcc aag 1123Gly Gly Leu Thr Tyr Ser Gly His Pro Leu Ala Val Ala Pro Ala Lys

330 335 340gca gcg ctg gag att tac gcg gaa gga gag atc att cca cgc gta gct 1171Ala Ala Leu Glu Ile Tyr Ala Glu Gly Glu Ile Ile Pro Arg Val Ala

345 350 355cga ctt ggc gct gaa ctg atc gaa cct cgc ctt cgt gaa cta gcg gaa 1219Arg Leu Gly Ala Glu Leu Ile Glu Pro Arg Leu Arg Glu Leu Ala Glu

360 365 370gaa aac gta gcg atc gct gac gtg cgg ggc atc gga ttc ttc tgg gca 1267GluAsn Val Ala Ile Ala Asp Val Arg Gly Ile Gly Phe Phe Trp Ala

375 380 385gtg gag ttc aat gca gac gcc act gcc atg gct gcc ggt gct gca gaa 1315Val Glu Phe Asn Ala Asp Ala Thr Ala Met Ala Ala Gly Ala Ala Glu390 395 400 405ttc aag gaa cgc ggc gtg tgg ccg atg atc tcc ggc aac cga ttc cac 1363Phe Lys Glu Arg Gly Val Trp Pro Met Ile Ser Gly Asn Arg Phe His

410 415 420atc gcg ccg ccg ctg acc acc act gat gac gaa ttg gta gca ctg ctg 1411Ile Ala Pro Pro Leu Thr Thr Thr Asp Asp Glu Leu Val Ala Leu Leu

425 430 435gac gcg gtg gaa gct gca gcc caa gct gtc gag ctg acc ttc gct ggg 1459Asp Ala Val Glu Ala Ala Ala Gln Ala Val Glu Leu Thr Phe Ala Gly

440 445 450gcg ttg ttc taagttttct agataacaag gcc 1491Ala Leu Phe

455<210>4<211>456<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>4Leu Ala Leu Lys Gly Tyr Thr Asn Phe Asp Gly Glu Phe Ile Glu Phe 151015 Gly Ser Val Gln Ala Lys Glu Glu Glu Lys Arg Ala Phe Asp Asn Asp

20 25 30Arg Ala His Val Phe His Ser Trp Ser Ala Gln Asp Lys Ile Ser Pro

35 40 45Lys Val Trp Ala Ala Ala Glu Gly Ser Thr Leu Tyr Asp Phe Asp Gly

50 55 60Asn Ala Phe Ile Asp Met Gly Ser Gln Leu Val Ser Ala Asn Leu Gly 65 70 75 80His Asn Asn Pro Arg Leu Val Glu Ala Ile Gln Arg Gln Ala Ala Arg

85 9095Leu Thr Asn Ile Asn Pro Ala Phe Gly Asn Asp Val Arg Ser Asp Val

100 105 110Ala Ala Lys Ile Val Ser Met Ala Arg Gly Glu Phe Ser His Val Phe

115 120 125Phe Thr Asn Gly Gly Ala Asp Ala Ile Glu His Ser Ile Arg Met Ala

130 135 140Arg Leu His Thr Gly Arg Asn Lys Ile Leu Ser Ala Tyr Arg Ser Tyr145 150 155 160His Gly Ala Thr Gly Ser Ala Met Met Leu Thr Gly Glu His Arg Arg

165 170 175Leu Gly Asn Pro Thr Thr Asp Pro Asp Ile Tyr His Phe Trp Ala Pro

180 185 190Phe Leu His His Ser Ser Phe Phe Ala Thr Thr Gln Glu Glu Glu Cys

195 200 205Glu Arg Ala Leu Lys His Leu Glu Asp Val Ile Ala Phe Glu Gly Ala

210 215 220Gly Met Ile Ala Ala Ile Val Leu Glu Pro Val Val Gly Ser Ser Gly225 230 235 240Ile Ile Leu Pro Pro Ala Gly Tyr Leu Asn Gly Val Arg Glu Leu Cys

245 250 255Asn Lys His Gly Ile Leu Phe Ile Ala Asp Glu Val Met Val Gly Phe

260 265 270Gly Arg Thr Gly Lys Leu Phe Ala Tyr Glu His Ala Gly Asp Asp Phe

275 280 285Gln Pro Asp Met Ile Thr Phe Ala Lys Gly Val Asn Ala Gly Tyr Ala

290 295 300Pro Leu Gly Gly Ile Val Met Thr Gln Ser Ile Arg Asp Thr Phe Gly305 310 315 320Ser Glu Ala Tyr Ser Gly Gly Leu Thr Tyr Ser Gly His Pro Leu Ala

325 330 335Val Ala Pro Ala Lys Ala Ala Leu Glu Ile Tyr Ala Glu Gly Glu Ile

340 345 350Ile Pro Arg Val Ala Arg Leu Gly Ala Glu Leu Ile Glu Pro Arg Leu

355 360 365Arg Glu Leu Ala Glu Glu Asn Val Ala Ile Ala Asp Val Arg Gly Ile

370 375 380Gly Phe Phe Trp Ala Val Glu Phe Asn Ala Asp Ala Thr Ala Met Ala385 390 395 400Ala Gly Ala Ala Glu Phe Lys Glu Arg Gly Val Trp Pro Met Ile Ser

405 410 415Gly Asn Arg Phe His Ile Ala Pro Pro Leu Thr Thr Thr Asp Asp Glu

420 425 430Leu Val Ala Leu Leu Asp Ala Val Glu Ala Ala Ala Gln Ala Val Glu

435 440 445Leu Thr Phe Ala Gly Ala Leu Phe

450455<210>5<211>1330<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1330)<223>FRXA01009<400>5aaccgacaaa acagccgttc acgtgctaaa gcagctcggc ttgatctagg gtgaggtgag 60ttatttaaag acttcataat attttgggga gtgaactggt ttg gca ttg aag ggt 115

Leu Ala Leu Lys Gly

1 5tac acc aac ttt gac ggt gaa ttc atc gaa ttc gga tct gtg caa gca 163Tyr Thr Asn Phe Asp Gly Glu Phe Ile Glu Phe Gly Ser Val Gln Ala

10 15 20aaa gaa gag gaa aaa cgg gca ttc gac aac gat cgc gcg cac gtt ttc 211Lys Glu Glu Glu Lys Arg Ala Phe Asp Asn Asp Arg Ala His Val Phe

25 30 35cac tcc tgg tcc gcg cag gac aaa atc agc ccc aaa gta tgg gca gct 259His Ser Trp Ser Ala Gln Asp Lys Ile Ser Pro Lys Val Trp Ala Ala

40 45 50gcc gaa ggt tcc acg ctg tac gac ttc gac ggc aac gcc ttc atc gac 307Ala Glu Gly Ser Thr Leu Tyr Asp Phe Asp Gly Asn Ala Phe Ile Asp

55 60 65atg ggt tcc caa ctt gtc tcg gca aac tta ggc cac aac aac cct cga 355Met Gly Ser Gln Leu Val Ser Ala Asn Leu Gly His Asn Asn Pro Arg 70 75 80 85tta gtt gag gcg atc cag cgc caa gca gcc cgg ttg acc aac atc aac 403Leu Val Glu Ala Ile Gln Arg Gln Ala Ala Arg Leu Thr Asn Ile Asn

90 95 100ccg gcc ttc ggc aat gat gtg cgc tct gat gtt gct gca aag atc gtg 451Pro Ala Phe Gly Asn Asp Val Arg Ser Asp Val Ala Ala Lys Ile Val

105 110 115tcg atg gcc cgt ggc gaa ttc tcc cac gtg ttt ttc acc aac ggc ggc 499Ser Met Ala Arg Gly Glu Phe Ser His Val Phe Phe Thr Asn Gly Gly

120 125 130gcc gac gcc atc gag cac tcc atc cgc atg gct cgc ctg cac acc gga 547Ala Asp Ala Ile Glu His Ser Ile Arg Met Ala Arg Leu His Thr Gly

135 140 145cgc aac aaa att ctg tcc gca tac cgc agc tac cae ggc gca acc gga 595Arg Asn Lys Ile Leu Ser Ala Tyr Arg Ser Tyr His Gly Ala Thr Gly150 155 160 165tcc gcg atg atg ctc acc ggc gaa cac cgc cgc ctg ggc aac ccc acc 643Ser Ala Met Met Leu Thr Gly Glu His Arg Arg Leu Gly Asn Pro Thr

170 175 180acc gac cca gat atc tac cac ttc tgg gca cca ttc ctg cac cac tcc 691Thr Asp Pro Asp Ile Tyr His Phe Trp Ala Pro Phe Leu His His Ser

185 190 195tca ttc ttt gcc acc acc caa gaa gaa gaa tgc gaa cgc gca ctc aag 739Ser Phe Phe Ala Thr Thr Gln Glu Glu Glu Cys Glu Arg Ala Leu Lys

200 205 210cac ttg gaa gat gtc atc gcg ttt gaa ggt gct ggc atg atc gca gcg 787His Leu Glu Asp Val Ile Ala Phe Glu Gly Ala Gly Met Ile Ala Ala

215 220 225atc gtc ctg gag cca gtg gtg gga tca tca gga atc atc ctg cca cca 835Ile Val Leu Glu Pro Val Val Gly Ser Ser Gly Ile Ile Leu Pro Pro230 235 240 245gca ggt tac tta aat ggc gtg cgc gaa ctt tgc aac aag cac ggc atc 883Ala Gly Tyr Leu Asn Gly Val Arg Glu Leu Cys Asn Lys His Gly Ile

250 255 260ctc ttc atc gcc gac gaa gtc atg gtc gga ttc gga cgc acc gga aaa 931Leu Phe Ile Ala Asp Glu Val Met Val Gly Phe Gly Arg Thr Gly Lys

265 270 275ctg ttt gct tac gag cat gct ggc gac gat ttc cag cca gac atg atc 979Leu Phe Ala Tyr Glu His Ala Gly Asp Asp Phe Gln Pro Asp Met Ile

280 285 290acc ttc gcc aag ggt gtt aac gca ggt tac gcc cca ctc ggt ggc atc 1027Thr Phe Ala Lys Gly Val Asn Ala Gly Tyr Ala Pro Leu Gly Gly Ile

295 300 305gtg atg acc caa tca atc cgc gat acc ttc gga tca gag gca tac tcc 1075Val Met Thr Gln Ser Ile Arg Asp Thr Phe Gly Ser Glu Ala Tyr Ser310 315 320 325ggc gga ctc acc tac tcc gga cac cca ctt gcagta gca ccc gcc aag 1123Gly Gly Leu Thr Tyr Ser Gly His Pro Leu Ala Val Ala Pro Ala Lys

330 335 340gca gcg ctg gag att tac gcg gaa gga gag atc att cca cgc gta gct 1171Ala Ala Leu Glu Ile Tyr Ala Glu Gly Glu Ile Ile Pro Arg Val Ala

345 350 355cga ctt ggc gct gaa ctg atc gaa cct cgc ctt cgt gaa cta gcg gaa 1219Arg Leu Gly Ala Glu Leu Ile Glu Pro Arg Leu Arg Glu Leu Ala Glu

360 365 370gaa aac gta gcg atc gct gac gtg cgg ggc atc gga ttc ttc tgg gca 1267Glu Asn Val Ala Ile Ala Asp Val Arg Gly Ile Gly Phe Phe Trp Ala

375 380 385gtg gag ttc aat gca gac gcc act gcc atg gct gcc ggt gct gca gaa 1315Val Glu Phe Asn Ala Asp Ala Thr Ala Met Ala Ala Gly Ala Ala Glu390 395 400 405ttc aag gaa cgc ggc 1330Phe Lys Glu Arg Gly

410<210>6<211>410<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>6Leu Ala Leu Lys Gly Tyr Thr Asn Phe Asp Gly Glu Phe Ile Glu Phe 151015 Gly Ser Val Gln Ala Lys Glu Glu Glu Lys Arg Ala Phe Asp Asn Asp

20 25 30Arg Ala His Val Phe His Ser Trp Ser Ala Gln Asp Lys Ile Ser Pro

35 40 45Lys Val Trp Ala Ala Ala Glu Gly Ser Thr Leu Tyr Asp Phe Asp Gly

50 55 60Asn Ala Phe Ile Asp Met Gly Ser Gln Leu Val Ser Ala Asn Leu Gly 65 70 75 80His Asn Asn Pro Arg Leu Val Glu Ala Ile Gln Arg Gln Ala Ala Arg

8590 95Leu Thr Asn Ile Asn Pro Ala Phe Gly Asn Asp Val Arg Ser Asp Val

100 105 110Ala Ala Lys Ile Val Ser Met Ala Arg Gly Glu Phe Ser His Val Phe

115 120 125Phe Thr Asn Gly Gly Ala Asp Ala Ile Glu His Ser Ile Arg Met Ala

130 135 140Arg Leu His Thr Gly Arg Asn Lys Ile Leu Ser Ala Tyr Arg Ser Tyr145 150 155 160His Gly Ala Thr Gly Ser Ala Met Met Leu Thr Gly Glu His Arg Arg

165 170 175Leu Gly Asn Pro Thr Thr Asp Pro Asp Ile Tyr His Phe Trp Ala Pro

180 185 190Phe Leu His His Ser Ser Phe Phe Ala Thr Thr Gln Glu Glu Glu Cys

195 200 205Glu Arg Ala Leu Lys His Leu Glu Asp Val Ile Ala Phe Glu Gly Ala

210 215 220Gly Met Ile Ala Ala Ile Val Leu Glu Pro Val Val Gly Ser Ser Gly225 230 235 240Ile Ile Leu Pro Pro Ala Gly Tyr Leu Asn Gly Val Arg Glu Leu Cys

245 250 255Asn Lys His Gly Ile Leu Phe Ile Ala Asp Glu Val Met Val Gly Phe

260 265 270Gly Arg Thr Gly Lys Leu Phe Ala Tyr Glu His Ala Gly Asp Asp Phe

275 280 285Gln Pro Asp Met Ile Thr Phe Ala Lys Gly Val Asn Ala Gly Tyr Ala

290 295 300Pro Leu Gly Gly Ile Val Met Thr Gln Ser Ile Arg Asp Thr Phe Gly305 310 315 320Ser Glu Ala Tyr Ser Gly Gly Leu Thr Tyr Ser Gly His Pro Leu Ala

325 330 335Val Ala Pro Ala Lys Ala Ala Leu Glu Ile Tyr Ala Glu Gly Glu Ile

340 345 350Ile Pro Arg Val Ala Arg Leu Gly Ala Glu Leu Ile Glu Pro Arg Leu

355 360 365Arg Glu Leu Ala Glu Glu Asn Val Ala Ile Ala Asp Val Arg Gly Ile

370 375 380Gly Phe Phe Trp Ala Val Glu Phe Asn Ala Asp Ala Thr Ala Met Ala385 390 395 400Ala Gly Ala Ala Glu Phe Lys Glu Arg Gly

405410<210>7<211>792<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (769)<223>RXC02390<400>7gctggtggtg ctgacccata cgctggaact ccaactgctg ttgataccgc caagatgttt 60ggccgcgagg atctcgtagc tcgcttcgag tcataggccg gtg gag tgg acc gct 115

Val Glu Trp Thr Ala

1 5ttt ggc acc ctg att ctg ctc aat ttg gtg ggc agt tta tcc ccg ggg 163Phe Gly Thr Leu Ile Leu Leu Asn Leu Val Gly Ser Leu Ser Pro Gly

10 15 20cct gat acc ttt ttc ctc ctc cgc tta gcc acc cgc tcc aga gcg cac 211Pro Asp Thr Phe Phe Leu Leu Arg Leu Ala Thr Arg Ser Arg Ala His

25 30 35gcg atc gct ggc gtc gcc ggc atc gtc acc gga ctc acg gtg tgg gtg 259Ala Ile Ala Gly Val Ala Gly Ile Val Thr Gly Leu Thr Val Trp Val

40 45 50acg ctg acg gtc gtggga gca gcg gcg ctg ctc acc act tat ccg tcg 307Thr Leu Thr Val Val Gly Ala Ala Ala Leu Leu Thr Thr Tyr Pro Ser

55 60 65att ctc gga atc atc cag ctc gtc ggc ggc acg tac cta agc ttc att 355Ile Leu Gly Ile Ile Gln Leu Val Gly Gly Thr Tyr Leu Ser Phe Ile 70 75 80 85ggg tac aag ttg ctg cgc tcg gcg tcg aga gag ctt atc gac gcc cgc 403Gly Tyr Lys Leu Leu Arg Ser Ala Ser Arg Glu Leu Ile Asp Ala Arg

90 95 100cag ttc cgt ttc aac gcc gat gcc cga cct atc ccg gat gcg gta gaa 451Gln Phe Arg Phe Asn Ala Asp Ala Arg Pro Ile Pro Asp Ala Val Glu

105 110 115gca ctg gga acc cgc act cag gta tat cga caa ggt ttg gcc acc aac 499Ala Leu Gly Thr Arg Thr Gln Val Tyr Arg Gln Gly Leu Ala Thr Asn

120 125 130ctg tca aac cct aaa gtt gtc atg tac ttc gcg gca att ctg gct ccg 547Leu Ser Asn Pro Lys Val Val Met Tyr Phe Ala Ala Ile Leu Ala Pro

135 140 145ttg atg cca gcg cac cca tca ccg gtg ctg gcg ttc tct atc atc gtg 595Leu Met Pro Ala His Pro Ser Pro Val Leu Ala Phe Ser Ile Ile Val150 155 160 165gcg att tta gtg cag acc ttt gtt acc ttc tct gct gtg tgc ctc att 643Ala Ile Leu Val Gln Thr Phe Val Thr Phe Ser Ala Val Cys Leu Ile

170 175 180gtc tct acg gag cgt gtg cgc aaa gca atg ctg cgt gca ggt ccc tgg 691Val Ser Thr Glu Arg Val Arg Lys Ala Met Leu Arg Ala Gly Pro Trp

185 190 195ttt gac ctg ctt gct ggc gtt gtc ttc ctc gtt gtg ggt gtg act ctg 739Phe Asp Leu Leu Ala Gly Val Val Phe Leu Val Val Gly Val Thr Leu

200 205 210ctg tat gaa ggc ctg gcc ggt tta ctc ggg taaaggcata aaaaatggct 789Leu Tyr Glu Gly Leu Thr Gly Leu Leu Gly

215220 tc 792<210>8<211>223<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>8Val Glu Trp Thr Ala Phe Gly Thr Leu Ile Leu Leu Asn Leu Val Gly 151015 Ser Leu Ser Pro Gly Pro Asp Thr Phe Phe Leu Leu Arg Leu Ala Thr

20 25 30Arg Ser Arg Ala His Ala Ile Ala Gly Val Ala Gly Ile Val Thr Gly

35 40 45Leu Thr Val Trp Val Thr Leu Thr Val Val Gly Ala Ala Ala Leu Leu

50 55 60Thr Thr Tyr Pro Ser Ile Leu Gly Ile Ile Gln Leu Val Gly Gly Thr 65 70 75 80Tyr Leu Ser Phe Ile Gly Tyr Lys Leu Leu Arg Ser Ala Ser Arg Glu

85 90 95Leu Ile Asp Ala Arg Gln Phe Arg Phe Asn Ala Asp Ala Arg Pro Ile

100 105 110Pro Asp Ala Val Glu Ala Leu Gly Thr Arg Thr Gln Val Tyr Arg Gln

115 120 125Gly Leu Ala Thr Asn Leu Ser Asn Pro Lys Val Val Met Tyr Phe Ala

130 135 140Ala Ile Leu Ala Pro Leu Met Pro Ala His Pro Ser Pro Val Leu Ala145 150 155 160Phe Ser Ile Ile Val Ala Ile Leu Val Gln Thr Phe Val Thr Phe Ser

165 170 175Ala Val Cys Leu Ile Val Ser Thr Glu Arg Val Arg Lys Ala Met Leu

180 185 190Arg Ala Gly Pro Trp Phe Asp Leu Leu Ala Gly Val Val Phe Leu Val

195 200 205Val Gly Val Thr Leu Leu Tyr Glu Gly Leu Thr Gly Leu Leu Gly

210215220<210>9<211>897<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (874)<223>RXC01796<400>9atgtaactcg atcaggtgga aatgcccgca aaagtggcgg cggtggccga gggatggccg 60ttggtgcggc atcggtggcc tgctactagt cgggctcttc ttg ctc ctt ggc ggt 115

Leu Leu Leu Gly Gly

1 5aac cct gcc gag atc gac cag gtt tta ggt ggc gat caa acc cag atc 163Asn Pro Ala Glu Ile Asp Gln Val Leu Gly Gly Asp Gln Thr Gln Ile

10 15 20gag tct gga gag tcc acc gga gcc ggc gac ttt gat cac tgc caa acc 211Glu Ser Gly Glu Ser Thr Gly Ala Gly Asp Phe Asp His Cys Gln Thr

25 30 35ggc gca gat gcc aac gcc agt gat gat tgt cgc ctt tac tac acc tca 259Gly Ala Asp Ala Asn Ala Ser Asp Asp Cys Arg Leu Tyr Tyr Thr Ser

40 45 50ttc tcc gtc aat gaa atg tgg cag act ttg ctt cca gct cag gct ggt 307Phe Set Val Asn Glu Met Trp Gln Thr Leu Leu Pro Ala Gln Ala Gly

55 60 65atc gaa tac acc gag ccg aca ttg act ctt ttc aaa aac tcc acc caa 355Ile Glu Tyr Thr Glu Pro Thr Leu Thr Leu Phe Lys Asn Ser Thr Gln 70 75 80 85acc ggc tgc ggt ttc gct tct gcg tcc act ggg ccg ttt tac tgt ccg 403Thr Gly Cys Gly Phe Ala Ser Ala Ser Thr Gly Pro Phe Tyr Cys Pro

90 95 100tca gac caa gat gct tat ttt gac ttg act ttc ttc gat cag atg cgt 451Ser Asp Gln Asp Ala Tyr Phe Asp Leu Thr Phe Phe Asp Gln Met Arg

105 110 115cag ttc ggt gca gaa aac gcc ccg ctt gcc cag atg tac atc gtg gcg 499Gln Phe Gly Ala Glu Asn Ala Pro Leu Ala Gln Met Tyr Ile Val Ala

120 125 130cac gag tac ggc cac cac gtc caa aac ctc gag ggc aca ctc gga ctg 547His Glu Tyr Gly His His Val Gln Asn Leu Glu Gly Thr Leu Gly Leu

135 140 145tcc aat tac aac gat ccg ggc gct gat tcc aac gcc gtc aag atc gag 595Ser Asn Tyr Asn Asp Pro Gly Ala Asp Ser Asn Ala Val Lys Ile Glu150 155 160 165ttg cag gcc gat tgc tac gca ggc att tgg gct aat cac tcc agc gaa 643Leu Gln Ala Asp Cys Tyr Ala Gly Ile Trp Ala Asn His Set Ser Glu

170 175 180ggc ccg gat ccg cta ctc caa ccc atc acc gaa tct gag cta gat tcc 691Gly Pro Asp Pro Leu Leu Gln Pro Ile Thr Glu Ser Glu Leu Asp Ser

185 190 195gct ctc ctt gct gca agc gcc gtg ggc gac gac aat atc cag caa cga 739Ala Leu Leu Ala Ala Ser Ala Val Gly Asp Asp Asn Ile Gln Gln Arg

200 205 210tcc ggt ggc gat gtc aat cct gaa agc tgg act cac ggc tca tcg cag 787Ser Gly Gly Asp Val Asn Pro Glu Ser Trp Thr His Gly Ser Ser Gln

215 220 225cag cgc aaa gac gcg ttc ctc gcc ggc tac aac acc ggc cag atg agc 835Gln Arg Lys Asp Ala Phe Leu Ala Gly Tyr Asn Thr Gly Gln Met Ser230 235 240 245gcc tgc gac ttc ctc ggc cgg ggc gtc tac aac gac gct taaagcattg 884Ala Cys Asp Phe Leu Gly Arg Gly Val Tyr Asn Asp Ala

250255 cttttcgacg tct 897<210>10<211>258<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>10Leu Leu Leu Gly Gly Asn Pro Ala Glu Ile Asp Gln Val Leu Gly Gly 151015 Asp Gln Thr Gln Ile Glu Ser Gly Glu Ser Thr Gly Ala Gly Asp Phe

20 25 30Asp His Cys Gln Thr Gly Ala Asp Ala Asn Ala Ser Asp Asp Cys Arg

35 40 45Leu Tyr Tyr Thr Ser Phe Ser Val Asn Glu Met Trp Gln Thr Leu Leu

50 55 60 Pro Ala Gln Ala Gly Ile Glu Tyr Thr Glu Pro Thr Leu Thr Leu Phe 65 70 75 80Lys Asn Ser Thr Gln Thr Gly Cys Gly Phe Ala Ser Ala Ser Thr Gly

85 90 95Pro Phe Tyr Cys Pro Ser Asp Gln Asp Ala Tyr Phe Asp Leu Thr Phe

100 105 110Phe Asp Gln Met Arg Gln Phe Gly Ala Glu Asn Ala Pro Leu Ala Gln

115 120 125Met Tyr Ile Val Ala His Glu Tyr Gly His His Val Gln Asn Leu Glu

130 135 140Gly Thr Leu Gly Leu Ser Asn Tyr Asn Asp Pro Gly Ala Asp Ser Asn145 150 155 160Ala Val Lys Ile Glu Leu Gln Ala Asp Cys Tyr Ala Gly Ile Trp Ala

165 170 175Asn His Ser Ser Glu Gly Pro Asp Pro Leu Leu Gln Pro Ile Thr Glu

180 185 190Ser Glu Leu Asp Ser Ala Leu Leu Ala Ala Ser Ala Val Gly Asp Asp

195200 205Asn Ile Gln Gln Arg Ser Gly Gly Asp Val Asn Pro Glu Ser Trp Thr

210 215 220His Gly Ser Ser Gln Gln Arg Lys Asp Ala Phe Leu Ala Gly Tyr Asn225 230 235 240Thr Gly Gln Met Ser Ala Cys Asp Phe Leu Gly Arg Gly Val Tyr Asn

245250255 Asp Ala<210>11<211>771<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<748)<223>RXC01207<400>11cttcatgatc tcaccggcag agcgcgtttt gttacagcgc gtaaactgtg actttgaaaa 60atttttgaac aatccgtaca ccaacttcag gagaaaaaca gtg agc aga atc tat 115

Val Ser Arg Ile Tyr

1 5gac tgt gcc gac caa gac tcc cgt gca gca ggc cta aag gcg gct gtc 163Asp Cys Ala Asp Gln Asp Ser Arg Ala Ala Gly Leu Lys Ala Ala Val

10 15 20gat gca gtc aaa gcc ggt cag ctc gtt gtc ctt ccc acg gat acc ctt 211Asp Ala Val Lys Ala Gly Gln Leu Val Val Leu Pro Thr Asp Thr Leu

25 30 35tat gga ctc ggc tgc gac gct ttc aac aac gag gca gta gcc aac ctt 259Tyr Gly Leu Gly Cys Asp Ala Phe Asn Asn Glu Ala Val Ala Asn Leu

40 45 50ctg gcc acc aaa cac cgt ggc ccc gat atg ccc gtt cca gtg ctc gtc 307Leu Ala Thr Lys His Arg Gly Pro Asp Met Pro Val Pro Val Leu Val

55 60 65ggc agc tgg gac acc att caa gga ctt gtg cac tcc tat tct gcg cag 355Gly Ser Trp Asp Thr Ile Gln Gly Leu Val His Ser Tyr Ser Ala Gln 70 75 80 85gca aaa gcg ctt gtg gag gcg ttc tgg cct ggt gga ctg tcc atc atc 403Ala Lys Ala Leu Val Glu Ala Phe Trp Pro Gly Gly Leu Ser Ile Ile

90 95 100gtt ccg cag gca cca agc ctt ccg tgg aac ctt ggc gat acc cgt ggc 451Val Pro Gln Ala Pro Ser Leu Pro Trp Asn Leu Gly Asp Thr Arg Gly

105 110 115acc gta atg ctg cgc atg cca ctg cac cca gtt gcc att gaa ttg ctg 499Thr Val Met Leu Arg Met Pro Leu His Pro Val Ala Ile Glu Leu Leu

120 125 130cgc caa acc gga cca atg gct gtc tcc tcc gcc aac atc tcc gga cat 547Arg Gln Thr Gly Pro Met Ala Val Ser Ser Ala Asn Ile Ser Gly His

135 140 145act cct cca acc acc gtg ctg gag gct cgt cag cag ctc aac caa aat 595Thr Pro Pro Thr Thr Val Leu Glu Ala Arg Gln Gln Leu Ash Gln Asn150 155 160 165gtc gct gtc tac ctc gat ggt ggc gaa tgc gcg ctg gcc acc cct tca 643Val Ala Val Tyr Leu Asp Gly Gly Glu Cys Ala Leu Ala Thr Pro Ser

170 175 180acc atc gtg gat att tca ggc ccc gca cca aag att ttg cgt gag ggt 691Thr Ile Val Asp Ile Ser Gly Pro Ala Pro Lys Ile Leu Arg Glu Gly

185 190 195gcc atc agc gca gaa cgc gtt ggc gaa gta ctt gga gtg tcg gca gaa 739Ala Ile Ser Ala Glu Arg Val Gly Glu Val Leu Gly Val Ser Ala Glu

200 205 210agc ctg cgc taaatgggag tcggtttcgc ggg 771Ser Leu Arg

215<210>12<211>216<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>12 Val Ser Arg Ile Tyr Asp Cys Ala Asp Gln Asp Ser Arg Ala Ala Gly 151015 Leu Lys Ala Ala Val Asp Ala Val Lys Ala Gly Gln Leu Val Val Leu

20 25 30Pro Thr Asp Thr Leu Tyr Gly Leu Gly Cys Asp Ala Phe Asn Asn Glu

35 40 45Ala Val Ala Asn Leu Leu Ala Thr Lys His Arg Gly Pro Asp Met Pro

50 55 60Val Pro Val Leu Val Gly Ser Trp Asp Thr Ile Gln Gly Leu Val His 65 70 75 80Ser Tyr Ser Ala Gln Ala Lys Ala Leu Val Glu Ala Phe Trp Pro Gly

85 90 95Gly Leu Ser Ile Ile Val Pro Gln Ala Pro Ser Leu Pro Trp Asn Leu

100 105 110Gly Asp Thr Arg Gly Thr Val Met Leu Arg Met Pro Leu His Pro Val

115 120 125Ala Ile Glu Leu Leu Arg Gln Thr Gly Pro Met Ala Val Ser Ser Ala

130 135 140Asn Ile Ser Gly His Thr Pro Pro Thr Thr Val Leu Glu Ala Arg Gln145 150 155 160Gln Leu Asn Gln Asn Val Ala Val Tyr Leu Asp Gly Gly Glu Cys Ala

165 170 175Leu Ala Thr Pro Ser Thr Ile Val Asp Ile Ser Gly Pro Ala Pro Lys

180 185 190Ile Leu Arg Glu Gly Ala Ile Ser Ala Glu Arg Val Gly Glu Val Leu

195 200 205Gly Val Ser Ala Glu Ser Leu Arg

210215<210>13<211>1026<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1003)<223>RXC00657<400>13gtgcggatcgggtatccgcg ctacacttag aggtgttaga gatcatgagt ttccacgaac 60tgtaacgcag gattcaccaa tcaatgaaag gtcgaccgac atg agc act gaa gac 115

Met Ser Thr Glu Asp

1 5att gtc gtc gta gca gta gat ggc tcg gac gcc tca aaa caa gct gtt 163Ile Val Val Val Ala Val Asp Gly Ser Asp Ala Ser Lys Gln Ala Val

10 15 20cgg tgg gct gca aat acc gcc aac aaa cgt ggc att cca ctt cgc ttg 211Arg Trp Ala Ala Asn Thr Ala Asn Lys Arg Gly Ile Pro Leu Arg Leu

25 30 35gct tcc agc tac acc atg cct cag ttc ctc tac gca gag gga atg gtt 259Ala Ser Ser Tyr Thr Met Pro Gln Phe Leu Tyr Ala Glu Gly Met Val

40 45 50cca cca caa gag ctt ttc gat gac ctc cag gcc gaa gcc ctg gaa aag 307Pro Pro Gln Glu Leu Phe Asp Asp Leu Gln Ala Glu Ala Leu Glu Lys

55 60 65att aac gaa gcc cgt gac atc gcc cat gag gta gcg cca gaa atc aag 355Ile Asn Glu Ala Arg Asp Ile Ala His Glu Val Ala Pro Glu Ile Lys 70 75 80 85atc ggg cac acc atc gct gaa ggc agt ccc ate gac atg ctg ttg gaa 403Ile Gly His Thr Ile Ala Glu Gly Ser Pro Ile Asp Met Leu Leu Glu

90 95 100atg tct ccc gat gcc aca atg atc gtc atg ggt tcc cgc gga ctc ggc 451Met Ser Pro Asp Ala Thr Met Ile Val Met Gly Ser Arg Gly Leu Gly

105 110 115gga ctc tcc gga atg gtc atg ggc tcc gtc tcc ggt gca gtg gtc agc 499Gly Leu Ser Gly Met Val Met Gly Ser Val Ser Gly Ala Val Val Ser

120 125130cac gca aag tgt cca gtc gtt gtt gtc cgt gaa gac agc gca gtc aac 547His Ala Lys Cys Pro Val Val Val Val Arg Glu Asp Ser Ala Val Asn

135 140 145gaa gac agc aag tac ggc cca gtc gtc gtc ggt gtg gat ggc tcc gaa 595Glu Asp Ser Lys Tyr Gly Pro Val Val Val Gly Val Asp Gly Ser Glu150 155 160 165gtc tcc caa cag gca acc gaa tac gca ttt gcg gaa gct gaa gct cgt 643Val Ser Gln Gln Ala Thr Glu Tyr Ala Phe Ala Glu Ala Glu Ala Arg

170 175 180ggc gcc gaa ctc gtt gca gtt cac acc tgg atg gac atg cag gta cag 691Gly Ala Glu Leu Val Ala Val His Thr Trp Met Asp Met Gln Val Gln

185 190 195gca tca ctt gca ggt ctt gca gct gct caa cag cag tgg gat gaa gtg 739Ala Ser Leu Ala Gly Leu Ala Ala Ala Gln Gln Gln Trp Asp Glu Val

200 205 210gaa cgt cag caa acc gac atg ctg atc gaa cgc ctc gca cca ctg gtg 787Glu Arg Gln Gln Thr Asp Met Leu Ile Glu Arg Leu Ala Pro Leu Val

215 220 225gaa aag tac cca agt gta acc gtc aag aag atc atc acc cgt gac cgc 835Glu Lys Tyr Pro Ser Val Thr Val Lys Lys Ile Ile Thr Arg Asp Arg230 235 240 245cca gtt cgc gca ctt gca gaa gca tct gaa aac gcg cag ctc cta gtc 883Pro Val Arg Ala Leu Ala Glu Ala Ser Glu Asn Ala Gln Leu Leu Val

250 255 260gtt ggt tcc cat ggt cgt ggc gga ttt aag ggc atg ctc ctt ggc tcc 931Val Gly Ser His Gly Arg Gly Gly Phe Lys Gly Met Leu Leu Gly Ser

265 270 275acc tcc cgc gca ctg ctg caa tcc gca ccg tgc cca atg atg gtg gtt 979Thr Ser Arg Ala Leu Leu Gln SerAla Pro Cys Pro Met Met Val Val

280 285 290cgc cca cct gag aag att aag aag tagtttcttt taagtttcga tgc 1026Arg Pro Pro Glu Lys Ile Lys Lys

295300<210>14<211>301<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>14 Met Ser Thr Glu Asp Ile Val Val Val Ala Val Asp Gly Ser Asp Ala 151015 Ser Lys Gln Ala Val Arg Trp Ala Ala Asn Thr Ala Asn Lys Arg Gly

20 25 30Ile Pro Leu Arg Leu Ala Ser Ser Tyr Thr Met Pro Gln Phe Leu Tyr

35 40 45Ala Glu Gly Met Val Pro Pro Gln Glu Leu Phe Asp Asp Leu Gln Ala

50 55 60Glu Ala Leu Glu Lys Ile Asn Glu Ala Arg Asp Ile Ala His Glu Val 65 70 75 80Ala Pro Glu Ile Lys Ile Gly His Thr Ile Ala Glu Gly Ser Pro Ile

85 90 95Asp Met Leu Leu Glu Met Ser Pro Asp Ala Thr Met Ile Val Met Gly

100 105 110Set Arg Gly Leu Gly Gly Leu Ser Gly Met Val Met Gly Ser Val Ser

115 120 125Gly Ala Val Val Ser His Ala Lys Cys Pro Val Val Val Val Arg Glu

130 135 140Asp Ser Ala Val Asn Glu Asp Ser Lys Tyr Gly Pro Val Val Val Gly145 150 155 160Val Asp Gly Ser Glu Val Ser Gln Gln Ala Thr Glu Tyr Ala Phe Ala

165 170 175Glu Ala Glu Ala Arg Gly Ala Glu Leu Val Ala Val His Thr Trp Met

180 185190Asp Met Gln Val Gln Ala Ser Leu Ala Gly Leu Ala Ala Ala Gln Gln

195 200 205Gln Trp Asp Glu Val Glu Arg Gln Gln Thr Asp Met Leu Ile Glu Arg

210 215 220Leu Ala Pro Leu Val Glu Lys Tyr Pro Ser Val Thr Val Lys Lys Ile225 230 235 240Ile Thr Arg Asp Arg Pro Val Arg Ala Leu Ala Glu Ala Ser Glu Asn

245 250 255Ala Gln Leu Leu Val Val Gly Ser His Gly Arg Gly Gly Phe Lys Gly

260 265 270Met Leu Leu Gly Ser Thr Ser Arg Ala Leu Leu Gln Ser Ala Pro Cys

275 280 285Pro Met Met Val Val Arg Pro Pro Glu Lys Ile Lys Lys

290295300<210>15<211>1059<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1036)<223>RXC00552<400>15ccgccaacaa ggcagcaaag ctcgatccaa ttgacgcctt gcgttatgag taaaagcctc 60gtttttaagg tagccacaca tcgcactaga ctgaagaact gtg gct acc tca gag 115

Val Ala Thr Ser Lys

1 5att ctt ctt tat tac gca ttc acc ccg ctc tct gac cct aaa gcg gtt 163Ile Leu Leu Tyr Tyr Ala Phe Thr Pro Leu Ser Asp Pro Lys Ala Val

10 15 20cag ctg tgg cag cgt gag ctc tgc gag tca ctg aat ctt cgt ggc cgc 211Gln Leu Trp Gln Arg Glu Leu Cys Glu Ser Leu Asn Leu Arg Gly Arg

25 30 35atc ctg atc tcc act cac ggc atc aat gga acc gtg ggc gga gat att 259IleLeu Ile Ser Thr His Gly Ile Asn Gly Thr Val Gly Gly Asp Ile

40 45 50gat gat tgc aag gcg tac att aaa aag acc cgc gag tac cca ggt ttc 307Asp Asp Cys Lys Ala Tyr Ile Lys Lys Thr Arg Glu Tyr Pro Gly Phe

55 60 65aac cgc atg cag ttt aag tgg tcc gag ggt ggc gct gag gat ttc cca 355Asn Arg Met Gln Phe Lys Trp Ser Glu Gly Gly Ala Glu Asp Phe Pro 70 75 80 85aag ctc agt gtc aaa gtc cgc gat gag atc gtt gcc ttc ggc gct cca 403Lys Leu Ser Val Lys Val Arg Asp Glu Ile Val Ala Phe Gly Ala Pro

90 95 100gat gag ctc aaa gtg gat gaa aac ggc gtc gtc ggt ggc ggc gtt cac 451Asp Glu Leu Lys Val Asp Glu Asn Gly Val Val Gly Gly Gly Val His

105 110 115ctg aaa cca cag cag gtc aat gag ctt gtg gaa gcc cgt ggc gat gaa 499Leu Lys Pro Gln Gln Val Asn Glu Leu Val Glu Ala Arg Gly Asp Glu

120 125 130gtt gtg ttc ttt gac ggc cgc aac gca atg gaa gcc cag atc ggc aag 547Val Val Phe Phe Asp Gly Arg Asn Ala Met Glu Ala Gln Ile Gly Lys

135 140 145ttc aag gac gct gtt gtc cct gac gta gaa acc act cat gat ttc atc 595Phe Lys Asp Ala Val Val Pro Asp Val Glu Thr Thr His Asp Phe Ile150 155 160 165gca gaa att gag tct gga aaa tac gac gat ctc aaa gac aag cct gtg 643Ala Glu Ile Glu Ser Gly Lys Tyr Asp Asp Leu Lys Asp Lys Pro Val

170 175 180gtc acc tac tgc acc ggc gga att cgt tgt gag atc ctg agt tca ctc 691Val Thr Tyr Cys Thr Gly Gly Ile Arg Cys Glu Ile Leu Ser Ser Leu

185190 195atg atc aac cgt ggt ttc aaa gag gtc tac caa atc gat ggc ggc atc 739Met Ile Asn Arg Gly Phe Lys Glu Val Tyr Gln Ile Asp Gly Gly Ile

200 205 210gtt cgc tac ggc gag cag ttt ggc aac aag ggc ctg tgg gaa ggc tcc 787Val Arg Tyr Gly Glu Gln Phe Gly Asn Lys Gly Leu Trp Glu Gly Ser

215 220 225ctc tac gtt ttc gat aag cgc atg cat atg gaa ttc ggc gag gat tac 835Leu Tyr Val Phe Asp Lys Arg Met His Met Glu Phe Gly Glu Asp Tyr230 235 240 245aaa gag gtc gga cac tgc atc cat tgc gat act ccc acc aac aaa ttt 883Lys Glu Val Gly His Cys Ile His Cys Asp Thr Pro Thr Asn Lys Phe

250 255 260gag cac tgc ctc aac gaa gat gat tgc cgc gag ctc gtg ttg atg tgc 931Glu His Cys Leu Asn Glu Asp Asp Cys Arg Glu Leu Val Leu Met Cys

265 270 275cct gat tgc ttc gcc aat gtt gag acc cgt cat tgc aag cgc gaa cgc 979Pro Asp Cys Phe Ala Asn Val Glu Thr Arg His Cys Lys Arg Glu Arg

280 285 290tgt gca gca att gct gcg gat ttc gct gag caa gga att gat ccg ctc 1027Cys Ala Ala Ile Ala Ala Asp Phe Ala Glu Gln Gly Ile Asp Pro Leu

295300305 gtt act tct taaaaagggt atggtggctg ggt 1059Val Thr Ser310<210>16<211>312<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>16 Val Ala Thr Ser Lys Ile Leu Leu Tyr Tyr Ala Phe Thr Pro Leu Ser 151015 Asp Pro Lys Ala Val Gln Leu Trp Gln Arg Glu Leu Cys Glu Ser Leu

20 25 30Asn Leu Arg Gly Arg Ile Leu Ile Ser Thr His Gly Ile Asn Gly Thr

35 4045Val Gly Gly Asp Ile Asp Asp Cys Lys Ala Tyr Ile Lys Lys Thr Arg

50 55 60Glu Tyr Pro Gly Phe Asn Arg Met Gln Phe Lys Trp Ser Glu Gly Gly 65 70 75 80Ala Glu Asp Phe Pro Lys Leu Ser Val Lys Val Arg Asp Glu Ile Val

85 90 95Ala Phe Gly Ala Pro Asp Glu Leu Lys Val Asp Glu Asn Gly Val Val

100 105 110Gly Gly Gly Val His Leu Lys Pro Gln Gln Val Asn Glu Leu Val Glu

115 120 125Ala Arg Gly Asp Glu Val Val Phe Phe Asp Gly Arg Asn Ala Met Glu

130 135 140Ala Gln Ile Gly Lys Phe Lys Asp Ala Val Val Pro Asp Val Glu Thr145 150 155 160Thr His Asp Phe Ile Ala Glu Ile Glu Ser Gly Lys Tyr Asp Asp Leu

165 170 175Lys Asp Lys Pro Val Val Thr Tyr Cys Thr Gly Gly Ile Arg Cys Glu

180 185 190Ile Leu Ser Ser Leu Met Ile Asn Arg Gly Phe Lys Glu Val Tyr Gln

195 200 205Ile Asp Gly Gly Ile Val Arg Tyr Gly Glu Gln Phe Gly Asn Lys Gly

210 215 220Leu Trp Glu Gly Ser Leu Tyr Val Phe Asp Lys Arg Met His Met Glu225 230 235 240Phe Gly Glu Asp Tyr Lys Glu Val Gly His Cys Ile His Cys Asp Thr

245 250 255Pro Thr Asn Lys Phe Glu His Cys Leu Asn Glu Asp Asp Cys Arg Glu

260 265 270Leu Val Leu Met Cys Pro Asp Cys Phe Ala Asn Val Glu Thr Arg His

275 280 285Cys Lys Arg Glu Arg Cys Ala Ala Ile Ala Ala Asp Phe Ala Glu Gln

290295300 Gly Ile Asp Pro Leu Val Thr Ser 305310<210>17<211>1578<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1555)<223>RXN00351<400>17gaaggctgct gctaagaaaa cgaccaagaa gaccactaag aaaactacta aaaagaccac 60cgcaaagaag accacaaaga agtcttaagc cggatcttat atg gat gat tcc aat 115

Met Asp Asp Ser Asn

1 5agc ttt gta gtt gtt gct aac cgt ctg cca gtg gat atg act gtc cac 163Ser Phe Val Val Val Ala Asn Arg Leu Pro Val Asp Met Thr Val His

10 15 20cca gat ggt agc tat agc atc tcc ccc agc ccc ggt ggc ctt gtc acg 211Pro Asp Gly Ser Tyr Ser Ile Ser Pro Ser Pro Gly Gly Leu Val Thr

25 30 35ggg ctt tcc ccc gtt ctg gaa caa cat cgt gga tgt tgg gtc gga tgg 259Gly Leu Ser Pro Val Leu Glu Gln His Arg Gly Cys Trp Val Gly Trp

40 45 50cct gga act gta gat gtt gca ccc gaa cca ttt cga aca gat acg ggt 307Pro Gly Thr Val Asp Val Ala Pro Glu Pro Phe Arg Thr Asp Thr Gly

55 60 65gtt ttg ctg cac cct gtt gtc ctc act gca agt gac tat gaa ggc ttc 355Val Leu Leu His Pro Val Val Leu Thr Ala Ser Asp Tyr Glu Gly Phe 70 75 80 85tac gag ggc ttt tca aac gca acg ctg tgg cct ctt ttc cac gat ctg 403Tyr Glu Gly Phe Ser Asn Ala Thr Leu Trp Pro Leu Phe His Asp Leu

90 95 100att gtt act ccg gtg tac aac acc gat tgg tgg cat gcg ttt cgg gag 451Ile Val Thr Pro Val Tyr Asn Thr Asp Trp Trp His Ala Phe Arg Glu

105 110 115gta aac ctc aag ttc gct gaa gcc gtg agc caa gtg gcg gca cac ggt 499Val Asn Leu Lys Phe Ala Glu Ala Val Ser Gln Val Ala Ala His Gly

120 125 130gcc act gtg tgg gtg cag gac tat cag ctg ttg ctg gtt cct ggc att 547Ala Thr Val Trp Val Gln Asp Tyr Gln Leu Leu Leu Val Pro Gly Ile

135 140 145ttg cgc cag atg cgc cct gat ttg aag atc ggt ttc ttc ctc cac att 595Leu Arg Gln Met Arg Pro Asp Leu Lys Ile Gly Phe Phe Leu His Ile150 155 160 165ccc ttc cct tcc cct gat ctg ttc cgt cag ctg ccg tgg cgt gaa gag 643Pro Phe Pro Ser Pro Asp Leu Phe Arg Gln Leu Pro Trp Arg Glu Glu

170 175 180att gtt cga ggc atg ctg ggc gca gat ttg gtg gga ttc cat ttg gtt 691Ile Val Arg Gly Met Leu Gly Ala Asp Leu Val Gly Phe His Leu Val

185 190 195caa aac gca gaa aac ttc ctt gcg tta acc cag cag gtt gcc ggc act 739Gln Asn Ala Glu Asn Phe Leu Ala Leu Thr Gln Gln Val Ala Gly Thr

200 205 210gcc ggg tct cat gtg ggt cag ccg gac acc ttg cag gtc agt ggt gaa 787Ala Gly Ser His Val Gly Gln Pro Asp Thr Leu Gln Val Ser Gly Glu

215 220 225gca ttg gtg cgt gag att ggc gct cat gtt gaa acc gct gac gga agg 835Ala Leu Val Arg Glu Ile Gly Ala His Val Glu Thr Ala Asp Gly Arg230 235 240 245cga gtt agc gtc ggg gcg ttc ccg atc tcg att gat gtt gaa atg ttt 883Arg Val Ser Val Gly Ala Phe Pro Ile Ser Ile Asp Val Glu Met Phe

250 255 260ggg gag gcg tcg aaa agc gcc gtt ctt gat ctt tta aaa acg ctc gac 931Gly Glu Ala Ser Lys Ser Ala Val Leu Asp Leu Leu Lys Thr Leu Asp

265 270 275gag ccg gaa acc gta ttc ctg ggc gtt gac cga ctg gac tac acc aag 979Glu Pro Glu Thr Val Phe Leu Gly Val Asp Arg Leu Asp Tyr Thr Lys

280 285 290ggc att ttg cag cgc ctg ctt gcg ttt gag gaa ctg ctg gaa tcc ggc 1027Gly Ile Leu Gln Arg Leu Leu Ala Phe Glu Glu Leu Leu Glu Ser Gly

295 300 305gcg ttg gag gcc gac aaa gct gtg ttg ctg cag gtc gcg acg cct tcg 1075Ala Leu Glu Ala Asp Lys Ala Val Leu Leu Gln Val Ala Thr Pro Ser310 315 320 325cgt gag cgc att gat cac tat cgt gtg tcg cgt tcg cag gtc gag gaa 1123Arg Glu Arg Ile Asp His Tyr Arg Val Ser Arg Ser Gln Val Glu Glu

330 335 340gcc gtc ggc cgt atc aat ggt cgt ttc ggt cgc atg ggg cgt ccc gtg 1171Ala Val Gly Arg Ile Asn Gly Arg Phe Gly Arg Met Gly Arg Pro Val

345 350 355gtg cat tat cta cac agg tca ttg agc aaa aat gat ctc cag gtg ctg 1219Val His Tyr Leu His Arg Ser Leu Ser Lys Asn Asp Leu Gln Val Leu

360 365 370tat acc gca gcc gat gtc atg ctg gtt acg cct ttt aaa gac ggt atg 1267Tyr Thr Ala Ala Asp Val Met Leu Val Thr Pro Phe Lys Asp Gly Met

375 380 385aac ttg gtg gct aaa gaa ttc gtg gcc aac cac cgc gac ggc act ggt 1315Asn Leu Val Ala Lys Glu Phe Val Ala Asn His Arg Asp Gly Thr Gly390 395 400 405gct ttg gtg ctg tcc gaa ttt gcc ggc gcg gcc act gag ctg acc ggt 1363Ala Leu Val Leu Ser Glu Phe Ala Gly Ala Ala Thr Glu Leu Thr Gly

410 415 420gcg tat tta tgc aac cca ttt gat gtg gaa tcc atc aaa cgg caa atg 1411Ala Tyr Leu Cys Asn Pro Phe Asp Val Glu Ser Ile Lys Arg Gln Met

425 430 435gtg gca gct gtc cat gat ttg aag cac aat ccg gaa tct gcg gca acg 1459Val Ala Ala Val His Asp Leu Lys His Asn Pro Glu Ser Ala Ala Thr

440 445 450cga atg aaa acg aac agc gag cag gtc tat acc cac gac gtc aac gtg 1507Arg Met Lys Thr Asn Ser Glu Gln Val Tyr Thr His Asp Val Asn Val

455460465 tgg gct aat agt ttc ctg gat tgt ttg gca cag tcg gga gaa aac tca 1555Trp Ala Asn Ser Phe Leu Asp Cys Leu Ala Gln Ser Gly Glu Asn Ser 470475480485 tgaaccggcc acgaatcgcg acc 1578<210>18<211>485<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>18 Met Asp Asp Ser Asn Ser Phe Val Val Val Ala Asn Arg Leu Pro Val 151015 Asp Met Thr Val His Pro Asp Gly Ser Tyr Ser Ile Ser Pro Ser Pro

20 25 30Gly Gly Leu Val Thr Gly Leu Ser Pro Val Leu Glu Gln His Arg Gly

35 40 45Cys Trp Val Gly Trp Pro Gly Thr Val Asp Val Ala Pro Glu Pro Phe

50 55 60Arg Thr Asp Thr Gly Val Leu Leu His Pro Val Val Leu Thr Ala Ser 65 70 75 80Asp Tyr Glu Gly Phe Tyr Glu Gly Phe Ser Asn Ala Thr Leu Trp Pro

85 90 95Leu Phe HisAsp Leu Ile Val Thr Pro Val Tyr Asn Thr Asp Trp Trp

100 105 110His Ala Phe Arg Glu Val Asn Leu Lys Phe Ala Glu Ala Val Ser Gln

115 120 125Val Ala Ala His Gly Ala Thr Val Trp Val Gln Asp Tyr Gln Leu Leu

130 135 140Leu Val Pro Gly Ile Leu Arg Gln Met Arg Pro Asp Leu Lys Ile Gly145 150 155 160Phe Phe Leu His Ile Pro Phe Pro Ser Pro Asp Leu Phe Arg Gln Leu

165 170 175Pro Trp Arg Glu Glu Ile Val Arg Gly Met Leu Gly Ala Asp Leu Val

180 185 190Gly Phe His Leu Val Gln Asn Ala Glu Asn Phe Leu Ala Leu Thr Gln

195 200 205Gln Val Ala Gly Thr Ala Gly Ser His Val Gly Gln Pro Asp Thr Leu

210 215 220Gln Val Ser Gly Glu Ala Leu Val Arg Glu Ile Gly Ala His Val Glu225 230 235 240Thr Ala Asp Gly Arg Arg Val Ser Val Gly Ala Phe Pro Ile Ser Ile

245 250 255Asp Val Glu Met Phe Gly Glu Ala Ser Lys Ser Ala Val Leu Asp Leu

260 265 270Leu Lys Thr Leu Asp Glu Pro Glu Thr Val Phe Leu Gly Val Asp Arg

275 280 285Leu Asp Tyr Thr Lys Gly Ile Leu Gln Arg Leu Leu Ala Phe Glu Glu

290 295 300Leu Leu Glu Ser Gly Ala Leu Glu Ala Asp Lys Ala Val Leu Leu Gln305 310 315 320Val Ala Thr Pro Ser Arg Glu Arg IleAsp His Tyr Arg Val Ser Arg

325 330 335Ser Gln Val Glu Glu Ala Val Gly Arg Ile Asn Gly Arg Phe Gly Arg

340 345 350Met Gly Arg Pro Val Val His Tyr Leu His Arg Ser Leu Ser Lys Asn

355 360 365Asp Leu Gln Val Leu Tyr Thr Ala Ala Asp Val Met Leu Val Thr Pro

370 375 380Phe Lys Asp Gly Met Asn Leu Val Ala Lys Glu Phe Val Ala Asn His385 390 395 400Arg Asp Gly Thr Gly Ala Leu Val Leu Ser Glu Phe Ala Gly Ala Ala

405 410 415Thr Glu Leu Thr Gly Ala Tyr Leu Cys Asn Pro Phe Asp Val Glu Ser

420 425 430Ile Lys Arg Gln Met Val Ala Ala Val His Asp Leu Lys His Asn Pro

435 440 445Glu Ser Ala Ala Thr Arg Met Lys Thr Asn Ser Glu Gln Val Tyr Thr

450 455 460His Asp Val Asn Val Trp Ala Asn Ser Phe Leu Asp Cys Leu Ala Gln465 470 475 480Ser Gly Glu Asn Ser

485<210>19<211>1546<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1546)<223>FRXA00351<400>19gaaggctgct gctaagaaaa cgaccaagaa gaccactaag aaaactacta aaaagaccac 60cgcaaagaag accacaaaga agtcttaagc cggatcttat atg gat gat tcc aat 115

Met Asp Asp Ser Asn

1 5agc ttt gta gtt gtt gct aaccgt ctg cca gtg gat atg act gtc cac 163Ser Phe Val Val Val Ala Asn Arg Leu Pro Val Asp Met Thr Val His

10 15 20cca gat ggt agc tat agc atc tcc ccc agc ccc ggt ggc ctt gtc acg 211Pro Asp Gly Ser Tyr Ser Ile Ser Pro Ser Pro Gly Gly Leu Val Thr

25 30 35ggg ctt tcc ccc gtt ctg gaa caa cat cgt gga tgt tgg gtc gga tgg 259Gly Leu Ser Pro Val Leu Glu Gln His Arg Gly Cys Trp Val Gly Trp

40 45 50cct gga act gta gat gtt gca ccc gaa cca ttt cga aca gat acg ggt 307Pro Gly Thr Val Asp Val Ala Pro Glu Pro Phe Arg Thr Asp Thr Gly

55 60 65gtt ttg ctg cac cot gtt gtc ctc act gca agt gac tat gaa ggc ttc 355Val Leu Leu His Pro Val Val Leu Thr Ala Ser Asp Tyr Glu Gly Phe70 75 80 85tac gag ggc ttt tca aac gca acg ctg tgg cct ctt ttc cac gat ctg 403Tyr Glu Gly Phe Ser Asn Ala Thr Leu Trp Pro Leu Phe His Asp Leu

90 95 100att gtt act ccg gtg tac aac acc gat tgg tgg cat gcg ttt cgg gag 451Ile Val Thr Pro Val Tyr Asn Thr Asp Trp Trp His Ala Phe Arg Glu

105 110 115gta aac ctc aag ttc gct gaa gcc gtg agc caa gtg gcg gca cac ggt 499Val Asn Leu Lys Phe Ala Glu Ala Val Ser Gln Val Ala Ala His Gly

120 125 130gcc act gtg tgg gtg cag gac tat cag ctg ttg ctg gtt cct ggc att 547Ala Thr Val Trp Val Gln Asp Tyr Gln Leu Leu Leu Val Pro Gly Ile

135 140 145ttg cgc cag atg cgc cct gat ttg aag atc ggt ttc ttc ctc cac att 595Leu Arg Gln Met Arg Pro Asp Leu Lys Ile Gly Phe PheLeu His Ile150 155 160 165ccc ttc cct tcc cct gat ctg ttc cgt cag ctg ccg tgg cgt gaa gag 643Pro Phe Pro Ser Pro Asp Leu Phe Arg Gln Leu Pro Trp Arg Glu Glu

170 175 180att gtt cga ggc atg ctg ggc gca gat ttg gtg gga ttc cat ttg gtt 691Ile Val Arg Gly Met Leu Gly Ala Asp Leu Val Gly Phe His Leu Val

185 190 195caa aac gca gaa aac ttc ctt gcg tta acc cag cag gtt gcc ggc act 739Gln Asn Ala Glu Asn Phe Leu Ala Leu Thr Gln Gln Val Ala Gly Thr

200 205 210gcc ggg tct cat gtg ggt cag ccg gac acc ttg cag gtc agt ggt gaa 787Ala Gly Ser His Val Gly Gln Pro Asp Thr Leu Gln Val Ser Gly Glu

215 220 225gca ttg gtg cgt gag att ggc gct cat gtt gaa acc gct gac gga agg 835Ala Leu Val Arg Glu Ile Gly Ala His Val Glu Thr Ala Asp Gly Arg230 235 240 245cga gtt agc gtc ggg gcg ttc ccg atc tcg att gat gtt gaa atg ttt 883Arg Val Ser Val Gly Ala Phe Pro Ile Ser Ile Asp Val Glu Met Phe

250 255 260ggg gag gcg tcg aaa agc gcc gtt ctt gat ctt tta aaa acg ctc gac 931Gly Glu Ala Ser Lys Ser Ala Val Leu Asp Leu Leu Lys Thr Leu Asp

265 270 275gag ccg gaa acc gta ttc ctg ggc gtt gac cga ctg gac tac acc aag 979Glu Pro Glu Thr Val Phe Leu Gly Val Asp Arg Leu Asp Tyr Thr Lys

280 285 290ggc att ttg cag cgc ctg ctt gcg ttt gag gaa ctg ctg gaa tcc ggc 1027Gly Ile Leu Gln Arg Leu Leu Ala Phe Glu Glu Leu Leu Glu Ser Gly

295 300 305gcg ttggag gcc gac aaa gct gtg ttg ctg cag gtc gcg acg cct tcg 1075Ala Leu Glu Ala Asp Lys Ala Val Leu Leu Gln Val Ala Thr Pro Ser310 315 320 325cgt gag cgc att gat cac tat cgt gtg tcg cgt tcg cag gtc gag gaa 1123Arg Glu Arg Ile Asp His Tyr Arg Val Ser Arg Ser Gln Val Glu Glu

330 335 340gcc gtc ggc cgt atc aat ggt cgt ttc ggt cgc atg ggg cgt ccc gtg 1171Ala Val Gly Arg Ile Asn Gly Arg Phe Gly Arg Met Gly Arg Pro Val

345 350 355gtg cat tat cta cac agg tca ttg agc aaa aat gat ctc cag gtg ctg 1219Val His Tyr Leu His Arg Ser Leu Ser Lys Asn Asp Leu Gln Val Leu

360 365 370tat acc gca gcc gat gtc atg ctg gtt acg cct ttt aaa gac ggt atg 1267Tyr Thr Ala Ala Asp Val Met Leu Val Thr Pro Phe Lys Asp Gly Met

375 380 385aac ttg gtg gct aaa gaa ttc gtg gcc aac cac cgc gac ggc act ggt 1315Asn Leu Val Ala Lys Glu Phe Val Ala Asn His Arg Asp Gly Thr Gly390 395 400 405gct ttg gtg ctg tcc gaa ttt gcc ggc gcg gcc act gag ctg acc ggt 1363Ala Leu Val Leu Ser Glu Phe Ala Gly Ala Ala Thr Glu Leu Thr Gly

410 415 420gcg tat tta tgc aac cca ttt gat gtg gaa tcc atc aaa cgg caa atg 1411Ala Tyr Leu Cys Asn Pro Phe Asp Val Glu Ser Ile Lys Arg Gln Met

425 430 435gtg gca gct gtc cat gat ttg aag cac aat ccg gaa tct gcg gca acg 1459Val Ala Ala Val His Asp Leu Lys His Asn Pro Glu Ser Ala Ala Thr

440 445 450cga atg aaa acg aac agc gag cag gtc tat acc cac gac gtc aac gtg 1507Arg Met Lys Thr Asn Ser Glu GlnVal Tyr Thr His Asp Val Asn Val

455460465 tgg gct aat agt ttc ctg gat tgt ttg gca cag tcg gga 1546Trp Ala Asn Ser Phe Leu Asp Cys Leu Ala Gln Ser Gly 470475480<210>20<211>482<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>20Met Asp Asp Ser Asn Ser Phe Val Val Val Ala Asn Arg Leu Pro Val 15l 015 Asp Met Thr Val His Pro Asp Gly Ser Tyr Ser Ile Ser Pro Ser Pro

20 25 30Gly Gly Leu Val Thr Gly Leu Ser Pro Val Leu Glu Gln His Arg Gly

35 40 45Cys Trp Val Gly Trp Pro Gly Thr Val Asp Val Ala Pro Glu Pro Phe

50 55 60Arg Thr Asp Thr Gly Val Leu Leu His Pro Val Val Leu Thr Ala Ser 65 70 75 80Asp Tyr Glu Gly Phe Tyr Glu Gly Phe Ser Asn Ala Thr Leu Trp Pro

85 90 95Leu Phe His Asp Leu Ile Val Thr Pro Val Tyr Asn Thr Asp Trp Trp

100 105 110His Ala Phe Arg Glu Val Asn Leu Lys Phe Ala Glu Ala Val Ser Gln

115 120 125Val Ala Ala His Gly Ala Thr Val Trp Val Gln Asp Tyr Gln Leu Leu

130 135 140Leu Val Pro Gly Ile Leu Arg Gln Met Arg Pro Asp Leu Lys Ile Gly145 150 155 160Phe Phe Leu His Ile Pro Phe Pro Ser Pro Asp Leu Phe Arg Gln Leu

165 170 175Pro Trp Arg Glu Glu Ile Val Arg Gly Met Leu Gly Ala Asp Leu Val

180 185 190Gly Phe His Leu Val Gln Asn Ala Glu Asn Phe Leu Ala Leu Thr Gln

195 200 205Gln Val Ala Gly Thr Ala Gly Ser His Val Gly Gln Pro Asp Thr Leu

210 215 220Gln Val Ser Gly Glu Ala Leu Val Arg Glu Ile Gly Ala His Val Glu225 230 235 240Thr Ala Asp Gly Arg Arg Val Ser Val Gly Ala Phe Pro Ile Ser Ile

245 250 255Asp Val Glu Met Phe Gly Glu Ala Ser Lys Ser Ala Val Leu Asp Leu

260 265 270Leu Lys Thr Leu Asp Glu Pro Glu Thr Val Phe Leu Gly Val Asp Arg

275 280 285Leu Asp Tyr Thr Lys Gly Ile Leu Gln Arg Leu Leu Ala Phe Glu Glu

290 295 300Leu Leu Glu Ser Gly Ala Leu Glu Ala Asp Lys Ala Val Leu Leu Gln305 310 315 320Val Ala Thr Pro Ser Arg Glu Arg Ile Asp His Tyr Arg Val Ser Arg

325 330 335Ser Gln Val Glu Glu Ala Val Gly Arg Ile Asn Gly Arg Phe Gly Arg

340 345 350Met Gly Arg Pro Val Val His Tyr Leu His Arg Ser Leu Ser Lys Asn

355 360 365Asp Leu Gln Val Leu Tyr Thr Ala Ala Asp Val Met Leu Val Thr Pro

370 375 380Phe Lys Asp Gly Met Asn Leu Val Ala Lys Glu Phe Val Ala Asn His385 390 395 400Arg Asp Gly Thr Gly Ala Leu Val Leu Ser Glu Phe Ala Gly Ale Ala

405 410 415Thr Glu Leu Thr Gly Ala Tyr Leu Cys Asn Pro Phe Asp Val Glu Ser

420 425 430Ile Lys Arg Gln Met Val Ala Ala Val His Asp Leu Lys His Asn Pro

435 440 445Glu Ser Ala Ala Thr Arg Met Lys Thr Asn Ser Glu Gln Val Tyr Thr

450455460 His Asp Val Asn Val Trp Ala Asn Ser Phe Leu Asp Cys Leu Ala Gln 465470475480 Ser Gly<210>21<211>779<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1).<756><223>RXA00873<400>21act gcc caa tgg ggt att ttc ctg cgt aat cat gat gag ctc acc ctt 48Thr Ala Gln Trp Gly Ile Phe Leu Arg Asn His Asp Glu Leu Thr Leu 151015 gaa atg gtc tcc gat gag gaa cgc agc tac atg tac tcc caa ttc gcc 96Glu Met Val Ser Asp Glu Glu Arg Ser Tyr Met Tyr Ser Gln Phe Ala<400>-21 act gcc caa tgg ggt att ttc ctg cgt aat cat gat gag ctc acc ctt Thr Ala Gln Trp Gly Ile Phe Leu Arg Asn His Asp Glu Leu Thr Leu gaa atg gtc tcc gat gag gaa cgc agc tac atg tac tcc caa ttc gcc

20 25 30tcc gaa cct cgc atg cgc gcc aac gta gga atc cgc agg cgc ctt tcc 144Ser Glu Pro Arg Met Arg Ala Asn Val Gly Ile Arg Arg Arg Leu Ser

35 40 45cca ctg ctt gaa ggc gac cgc aac cag ctg gaa ctc ctt cac ggt ttg 192Pro Leu Leu Glu Gly Asp Arg Asn Gln Leu Glu Leu Leu His Gly Leu

50 55 60ttg ctg tct cta cct ggc tca ccc gtg ttg tat tac ggt gat gaa att 240Leu Leu Ser Leu Pro Gly Ser Pro Val Leu Tyr Tyr Gly Asp Glu Ile 65 70 75 80ggc atg ggc gac aat atc tgg ctc cac gac cgc gac gga gtg cgc acc 288Gly Met Gly Asp Asn Ile Trp Leu His Asp Arg Asp Gly Val Arg Thr

8590 95ccc atg cag tgg tcc aac gac cgc aac ggt ggt ttc tcc aaa gct gat 336Pro Met Gln Trp Ser Asn Asp Arg Asn Gly Gly Phe Ser Lys Ala Asp

100 105 110cct gaa cgc ctg tac ctt cca gcg atc caa aat gat caa tac ggc tac 384Pro Glu Arg Leu Tyr Leu Pro Ala Ile Gln Asn Asp Gln Tyr Gly Tyr

115 120 125gcc caa gta aac gtg gaa agc caa ctc aac cgc gaa aac tcc ctg ctg 432Ala Gln Val Asn Val Glu Ser Gln Leu Asn Arg Glu Asn Ser Leu Leu

130 135 140cgc tgg ctc cga aac caa atc ctt atc cgc aag cag tac cgc gca ttt 480Arg Trp Leu Arg Asn Gln Ile Leu Ile Arg Lys Gln Tyr Arg Ala Phe145 150 155 160ggt gcc gga acc tac cgt gaa gtg tcc tcc acc aat gag tca gtg ttg 528Gly Ala Gly Thr Tyr Arg Glu Val Ser Ser Thr Asn Glu Ser Val Leu

165 170 175aca ttt tta cga gaa cac aag ggc caa acc att ttg tgt gtc aac aac 576Thr Phe Leu Arg Glu His Lys Gly Gln Thr Ile Leu Cys Val Asn Asn

180 185 190atg agc aaa tat cct cag gca gtc tcg ctt gat ttg cgt gaa ttt gca 624Met Ser Lys Tyr Pro Gln Ala Val Ser Leu Asp Leu Arg Glu Phe Ala

195 200 205gga cac acc cct cga gag atg tcg ggc ggg cag ctg ttc cct acc att 672Gly His Thr Pro Arg Glu Met Ser Gly Gly Gln Leu Phe Pro Thr Ile

210 215 220gct gaa cgg gag tgg att gtc act tta gcc cct cac gga ttc ttc tgg 720Ala Glu Arg Glu Trp Ile Val Thr Leu Ala Pro His Gly Phe Phe Trp225 230 235 240ttt gat ctc acc gcc gat gaa aag gac gat atg gaa tgagcattgg 766Phe Asp Leu Thr Ala Asp Glu Lys Asp Asp Met Glu

245250 ccaacacatc atc 779<210>22<211>252<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>22Thr Ala Gln Trp Gly Ile Phe Leu Arg Asn His Asp Glu Leu Thr Leu 151015 Glu Met Val Set Asp Glu Glu Arg Ser Tyr Met Tyr Ser Gln Phe Ala

20 25 30Ser Glu Pro Arg Met Arg Ala Asn Val Gly Ile Arg Arg Arg Leu Ser

35 40 45Pro Leu Leu Glu Gly Asp Arg Asn Gln Leu Glu Leu Leu His Gly Leu

50 55 60Leu Leu Ser Leu Pro Gly Ser Pro Val Leu Tyr Tyr Gly Asp Glu Ile 65 70 75 80Gly Met Gly Asp Asn Ile Trp Leu His Asp Arg Asp Gly Val Arg Thr

85 90 95Pro Met Gln Trp Ser Asn Asp Arg Asn Gly Gly Phe Ser Lys Ala Asp

100 105 110Pro Glu Arg Leu Tyr Leu Pro Ala Ile Gln Asn Asp Gln Tyr Gly Tyr

115 120 125Ala Gln Val Asn Val Glu Ser Gln Leu Asn Arg Glu Asn Ser Leu Leu

130 135 140Arg Trp Leu Arg Asn Gln Ile Leu Ile Arg Lys Gln Tyr Arg Ala Phe145 150 155 160Gly Ala Gly Thr Tyr Arg Glu Val Ser Ser Thr Asn Glu Ser Val Leu

165 170 175Thr Phe Leu Arg Glu His Lys Gly Gln Thr Ile Leu Cys Val Asn Asn

180 185 190Met Ser Lys Tyr Pro Gln Ala Val Ser Leu Asp Leu Arg Glu Phe Ala

195 200 205Gly His Thr Pro Arg Glu Met Ser Gly Gly Gln Leu Phe Pro Thr Ile

210 215 220Ala Glu Arg Glu Trp Ile Val Thr Leu Ala Pro His Gly Phe Phe Trp225 230 235 240Phe Asp Leu Thr Ala Asp Glu Lys Asp Asp Met Glu

245250<210>23<211>1102<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1102)<223>RXA00891<400>23tcaatattcc gaagaaaacc gcgcagctct ctcactagtc tcaggtgagg cgaaagtggt 60gaaagacccg ctacgcatgg tgcgcctggc tttttagaat gtg ctg caa acc tcc 115

Val Leu Gln Thr Ser

1 5tgg cat ttc tct atc ctg gca ggc atg act gat acc tct ccg ttg aat 163Trp His Phe Ser Ile Leu Ala Gly Met Thr Asp Thr Ser Pro Leu Asn

10 15 20tct cag ccg agt gca gat cac cac cct gat cac gcg gct cgc cca gtt 211Ser Gln Pro Ser Ala Asp His His Pro Asp His Ala Ala Arg Pro Val

25 30 35ctt gat gcc cac ggc ttg atc gtt gag cac gaa tcg gaa gag ttt cca 259Leu Asp Ala His Gly Leu Ile Val Glu His Glu Ser Glu Glu Phe Pro

40 45 50gtc ccc gca ccc gct ccc ggt gaa cag ccc tgg gag aag aaa aac cgc 307Val Pro Ala Pro Ala Pro Gly Glu Gln Pro Trp Glu Lys Lys Asn Arg

55 60 65gag tgg tac aaa gac gcc gtt ttc tac gaa gtg ctg gtt cgt gcc ttc 355Glu Trp Tyr Lys Asp Ala Val Phe Tyr Glu Val Leu Val Arg Ala Phe 70 75 80 85tac gat cca gaa ggc aac gga gtc gga tcg ttg aaa ggc ctg acc gaa 403TyrAsp Pro Glu Gly Asn Gly Val Gly Ser Leu Lys Gly Leu Thr Glu

90 95 100aaa ctg gat tac atc cag tgg ctc ggc gtg gat tgc att tgg atc cca 451Lys Leu Asp Tyr Ile Gln Trp Leu Gly Val Asp Cys Ile Trp Ile Pro

105 110 115ccg ttt tat gat tcc cca ctg cgc gac ggc ggt tac gat atc cgc aac 499Pro Phe Tyr Asp Ser Pro Leu Arg Asp Gly Gly Tyr Asp Ile Arg Asn

120 125 130ttc cgt gaa atc ctg ccc gaa ttc ggc acc gtc gat gac ttc gtg gaa 547Phe Arg Glu Ile Leu Pro Glu Phe Gly Thr Val Asp Asp Phe Val Glu

135 140 145ctc gtt gac cac gcc cac cgc cgt ggc ctg cgt gtt atc acc gac ttg 595Leu Val Asp His Ala His Arg Arg Gly Leu Arg Val Ile Thr Asp Leu150 155 160 165gtc atg aat cac acc tcc gac cag cac gca tgg ttc caa gaa tcc cgg 643Val Met Asn His Thr Ser Asp Gln His Ala Trp Phe Gln Glu Ser Arg

170 175 180cgc gac cca acc ggc ccc tac gga gat ttc tat gtg tgg agc gat gat 691Arg Asp Pro Thr Gly Pro Tyr Gly Asp Phe Tyr Val Trp Ser Asp Asp

185 190 195ccc acc ctg tac aac gaa gcc cgc atc atc ttt gta gat aca gaa gaa 739Pro Thr Leu Tyr Asn Glu Ala Arg Ile Ile Phe Val Asp Thr Glu Glu

200 205 210tcc aac tgg acc tat gat ccg gtg cgt ggc cag tac ttc tgg cac cgc 787Ser Asn Trp Thr Tyr Asp Pro Val Arg Gly Gln Tyr Phe Trp His Arg

215 220 225ttc ttc tcc cac caa cca gac ctc aac tac gac aac ccc gca gtc caa 835Phe Phe Ser His Gln Pro Asp Leu Asn Tyr Asp Asn Pro Ala Val Gln230 235240 245gag gcc atg cta gat gtc ttg cgt ttc tgg ctg gac ctg gga ctt gat 883Glu Ala Met Leu Asp Val Leu Arg Phe Trp Leu Asp Leu Gly Leu Asp

250 255 260ggt ttc cga cta gat gcc gtt cct tat ctt ttt gaa cgc gaa ggc acc 931Gly Phe Arg Leu Asp Ala Val Pro Tyr Leu Phe Glu Arg Glu Gly Thr

265 270 275aac ggc gaa aac ctc aaa gaa acc cac gat ttc ctc aaa ctg tgt cgc 979Asn Gly Glu Asn Leu Lys Glu Thr His Asp Phe Leu Lys Leu Cys Arg

280 285 290tct gtc att gag aag gaa tac ccc ggc cga atc ctg ctc gca gaa gcc 1027Ser Val Ile Glu Lys Glu Tyr Pro Gly Arg Ile Leu Leu Ala Glu Ala

295 300 305aac caa tgg ccc caa gat gtg gtc gaa tac ttc ggt gaa aaa gac aaa 1075Asn Gln Trp Pro Gln Asp Val Val Glu Tyr Phe Gly Glu Lys Asp Lys310 315 320 325ggc gat gaa tgc cac atg gcc ttc cac 1102Gly Asp Glu Cys His Met Ala Phe His

330<210>24<211>334<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>24Val Leu Gln Thr Ser Trp His Phe Ser Ile Leu Ala Gly Met Thr Asp 151015 Thr Ser Pro Leu Asn Ser Gln Pro Ser Ala Asp His His Pro Asp His

20 25 30Ala Ala Arg Pro Val Leu Asp Ala His Gly Leu Ile Val Glu His Glu

35 40 45Ser Glu Glu Phe Pro Val Pro Ala Pro Ala Pro Gly Glu Gln Pro Trp

50 55 60Glu Lys Lys Asn Arg Glu Trp Tyr Lys Asp Ala Val Phe Tyr Glu Val 65 70 75 80Leu Val Arg Ala Phe Tyr Asp Pro Glu Gly Asn Gly Val Gly Ser Leu

85 90 95Lys Gly Leu Thr Glu Lys Leu Asp Tyr Ile Gln Trp Leu Gly Val Asp

100 105 110Cys Ile Trp Ile Pro Pro Phe Tyr Asp Ser Pro Leu Arg Asp Gly Gly

115 120 125Tyr Asp Ile Arg Asn Phe Arg Glu Ile Leu Pro Glu Phe Gly Thr Val

130 135 140Asp Asp Phe Val Glu Leu Val Asp His Ala His Arg Arg Gly Leu Arg145 150 155 160Val Ile Thr Asp Leu Val Met Asn His Thr Ser Asp Gln His Ala Trp

165 170 175Phe Gln Glu Ser Arg Arg Asp Pro Thr Gly Pro Tyr Gly Asp Phe Tyr

180 185 190Val Trp Ser Asp Asp Pro Thr Leu Tyr Asn Glu Ala Arg Ile Ile Phe

195 200 205Val Asp Thr Glu Glu Ser Asn Trp Thr Tyr Asp Pro Val Arg Gly Gln

210 215 220Tyr Phe Trp His Arg Phe Phe Ser His Gln Pro Asp Leu Asn Tyr Asp225 230 235 240Asn Pro Ala Val Gln Glu Ala Met Leu Asp Val Leu Arg Phe Trp Leu

245 250 255Asp Leu Gly Leu Asp Gly Phe Arg Leu Asp Ala Val Pro Tyr Leu Phe

260 265 270Glu Arg Glu Gly Thr Asn Gly Glu Asn Leu Lys Glu Thr His Asp Phe

275 280 285Leu Lys Leu Cys Arg Ser Val Ile Glu Lys Glu Tyr Pro Gly Arg Ile

290 295 300Leu Leu Ala Glu Ala Asn Gln Trp Pro Gln Asp Val Val Glu Tyr Phe305 310 315 320Gly Glu Lys Asp Lys Gly Asp Glu Cys His Met Ala Phe His

325330<210>25<211>1386<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1363)<223>RXA00534<400>25ctgtgcagaa agaaaacact cctctggcta ggtagacaca gtttataaag gtagagttga 60gcgggtaact gtcagcacgt agatcgaaag gtgcacaaag gtg gcc ctg gtc gta 115

Val Ala Leu Val Val

1 5cag aaa tat ggc ggt tcc tcg ctt gag agt gcg gaa cgc att aga aac 163Gln Lys Tyr Gly Gly Ser Ser Leu Glu Ser Ala Glu Arg Ile Arg Asn

10 15 20gtc gct gaa cgg atc gtt gcc acc aag aag gct gga aat gat gtc gtg 211Val Ala Glu Arg Ile Val Ala Thr Lys Lys Ala Gly Asn Asp Val Val

25 30 35gtt gtc tgc tcc gca atg gga gac acc acg gat gaa ctt cta gaa ctt 259Val Val Cys Ser Ala Met Gly Asp Thr Thr Asp Glu Leu Leu Glu Leu

40 45 50gca gcg gca gtg aat ccc gtt ccg cca gct cgt gaa atg gat atg ctc 307Ala Ala Ala Val Asn Pro Val Pro Pro Ala Arg Glu Met Asp Met Leu

55 60 65ctg act gct ggt gag cgt att tct aac gct ctc gtc gcc atg gct att 355Leu Thr Ala Gly Glu Arg Ile Ser Asn Ala Leu Val Ala Met Ala Ile 70 75 80 85gag tcc ctt ggc gca gaa gcc caa tct ttc acg ggc tct cag gct ggt 403Glu Ser Leu Gly Ala Glu Ala Gln Ser Phe Thr Gly Ser Gln Ala Gly

90 95100gtg ctc acc acc gag cgc cac gga aac gca cgc att gtt gat gtc act 451Val Leu Thr Thr Glu Arg His Gly Asn Ala Arg Ile Val Asp Val Thr

105 110 115cca ggt cgt gtg cgt gaa gca ctc gat gag ggc aag atc tgc att gtt 499Pro Gly Arg Val Arg Glu Ala Leu Asp Glu Gly Lys Ile Cys Ile Val

120 125 130gct ggt ttc cag ggt gtt aat aaa gaa acc cgc gat gtc acc acg ttg 547Ala Gly Phe Gln Gly Val Asn Lys Glu Thr Arg Asp ValThr Thr Leu

135 140 145ggt cgt ggt ggt tct gac acc act gca gtt gcg ttg gca gct gct ttg 595Gly Arg Gly Gly Ser Asp Thr Thr Ala Val Ala Leu Ala Ala Ala Leu150 155 160 165aac gct gat gtg tgt gag att tac tcg gac gtt gac ggt gtg tat acc 643Asn Ala Asp Val Cys Glu Ile Tyr Ser Asp Val Asp Gly Val Tyr Thr

170 175 180gct gac ccg cgc atc gtt cct aat gca cag aag ctg gaa aag ctc agc 691Ala Asp Pro Arg Ile Val Pro Asn Ala Gln Lys Leu Glu Lys Leu Ser

185 190 195ttc gaa gaa atg ctg gaa ctt gct gct gtt ggc tcc aag att ttg gtg 739Phe Glu Glu Met Leu Glu Leu Ala Ala Val Gly Ser Lys Ile Leu Val

200 205 210ctg cgc agt gtt gaa tac gct cgt gca ttc aat gtg cca ctt cgc gta 787Leu Arg Ser Val Glu Tyr Ala Arg Ala Phe Asn Val Pro Leu Arg Val

215 220 225cgc tcg tct tat agt aat gat ccc ggc act ttg att gcc ggc tct atg 835Arg Ser Ser Tyr Ser Asn Asp Pro Gly Thr Leu Ile Ala Gly Ser Met230 235 240 245gag gat att cct gtg gaa gaa gca gtc ctt acc ggt gtc gca acc gac 883Glu Asp Ile Pro Val Glu Glu Ala Val Leu Thr GlyVal Ala Thr Asp

250 255 260aag tcc gaa gcc aaa gta acc gtt ctg ggt att tcc gat aag cca ggc 931Lys Ser Glu Ala Lys Val Thr Val Leu Gly Ile Ser Asp Lys Pro Gly

265 270 275gag gct gcg aag gtt ttc cgt gcg ttg gct gat gca gaa atc aac att 979Glu Ala Ala Lys Val Phe Arg Ala Leu Ala Asp Ala Glu Ile Asn Ile

280 285 290gac atg gtt ctg cag aac gtc tct tct gta gaa gac ggc acc acc gac 1027Asp Met Val Leu Gln Asn Val Ser Ser Val Glu Asp Gly Thr Thr Asp

295 300 305atc acc ttc acc tgc cct cgt tcc gac ggc cgc cgc gcg atg gag atc 1075Ile Thr Phe Thr Cys Pro Arg Ser Asp Gly Arg Arg Ala Met Glu Ile310 315 320 325ttg aag aag ctt cag gtt cag ggc aac tgg acc aat gtg ctt tac gac 1123Leu Lys Lys Leu Gln Val Gln Gly Asn Trp Thr Asn Val Leu Tyr Asp

330 335 340gac cag gtc ggc aaa gtc tcc ctc gtg ggt gct ggc atg aag tct cac 1171Asp Gln Val Gly Lys Val Ser Leu Val Gly Ala Gly Met Lys Ser His

345 350 355cca ggt gtt acc gca gag ttc atg gaa gct ctg cgc gat gtc aac gtg 1219Pro Gly Val Thr Ala Glu Phe Met Glu Ala Leu Arg Asp Val Asn Val

360 365 370aac atc gaa ttg att tcc acc tot gag att cgt att tcc gtg ctg atc 1267Asn Ile Glu Leu Ile Ser Thr Ser Glu Ile Arg Ile Ser Val Leu Ile

375 380 385cgt gaa gat gat ctg gat gct gct gca cgt gca ttg cat gag cag ttc 1315Arg Glu Asp Asp Leu Asp Ala Ala Ala Arg Ala Leu His Glu Gln Phe390 395 400 405cag ctgggc ggc gaa gac gaa gcc gtc gtt tat gca ggc acc gga cgc 1363Gln Leu Gly Gly Glu Asp Glu Ala Val Val Tyr Ala Gly Thr Gly Arg

410415420 taaagtttta aaggagtagt ttt 1385<210>26<211>421<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>26Val Ala Leu Val Val Gln Lys Tyr Gly Gly Ser Ser Leu Glu Ser Ala 151015 Glu Arg Ile Arg Asn Val Ala Glu Arg Ile Val Ala Thr Lys Lys Ala

20 25 30Gly Asn Asp Val Val Val Val Cys Ser Ala Met Gly Asp Thr Thr Asp

35 40 45Glu Leu Leu Glu Leu Ala Ala Ala Val Asn Pro Val Pro Pro Ala Arg

50 55 60Glu Met Asp Met Leu Leu Thr Ala Gly Glu Arg Ile Ser Asn Ala Leu 65 70 75 80Val Ala Met Ala Ile Glu Ser Leu Gly Ala Glu Ala Gln Ser Phe Thr

85 90 95Gly Ser Gln Ala Gly Val Leu Thr Thr Glu Arg His Gly Asn Ala Arg

100 105 110Ile Val Asp Val Thr Pro Gly Arg Val Arg Glu Ala Leu Asp Glu Gly

115 120 125Lys Ile Cys Ile Val Ala Gly Phe Gln Gly Val Asn Lys Glu Thr Arg

130 135 140Asp Val Thr Thr Leu Gly Arg Gly Gly Ser Asp Thr Thr Ala Val Ala145 150 155 160Leu Ala Ala Ala Leu Asn Ala Asp Val Cys Glu Ile Tyr Ser Asp Val

165 170 175Asp Gly Val Tyr Thr Ala Asp Pro Arg Ile Val Pro Asn Ala Gln Lys

180 185 190Leu Glu Lys Leu Ser Phe Glu GluMet Leu Glu Leu Ala Ala Val Gly

195 200 205Ser Lys Ile Leu Val Leu Arg Ser Val Glu Tyr Ala Arg Ala Phe Asn

210 215 220Val Pro Leu Arg Val Arg Ser Ser Tyr Ser Asn Asp Pro Gly Thr Leu225 230 235 240Ile Ala Gly Ser Met Glu Asp Ile Pro Val Glu Glu Ala Val Leu Thr

245 250 255Gly Val Ala Thr Asp Lys Ser Glu Ala Lys Val Thr Val Leu Gly Ile

260 265 270Ser Asp Lys Pro Gly Glu Ala Ala Lys Val Phe Arg Ala Leu Ala Asp

275 280 285Ala Glu Ile Asn Ile Asp Met Val Leu Gln Asn Val Ser Ser Val Glu

290 295 300Asp Gly Thr Thr Asp Ile Thr Phe Thr Cys Pro Arg Ser Asp Gly Arg305 310 315 320Arg Ala Met Glu Ile Leu Lys Lys Leu Gln Val Gln Gly Asn Trp Thr

325 330 335Asn Val Leu Tyr Asp Asp Gln Val Gly Lys Val Ser Leu Val Gly Ala

340 345 350Gly Met Lys Ser His Pro Gly Val Thr Ala Glu Phe Met Glu Ala Leu

355 360 365Arg Asp Val Asn Val Asn Ile Glu Leu Ile Ser Thr Ser Glu Ile Arg

370 375 380Ile Ser Val Leu Ile Arg Glu Asp Asp Leu Asp Ala Ala Ala Arg Ala385 390 395 400Leu His Glu Gln Phe Gln Leu Gly Gly Glu Asp Glu Ala Val Val Tyr

405 410 415Ala Gly Thr Gly Arg

420<210>27<211>1155<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1132)<223>RXA00533<400>27ctgcacgtgc attgcatgag cagttccagc tgggcggcga agacgaagcc gtcgtttatg 60caggcaccgg acgctaaagt tttaaaggag tagttttaca atg acc acc atc gca 115

Met Thr Thr Ile Ala

1 5gtt gtt ggt gca acc ggc cag gtc ggc cag gtt atg cgc acc ctt ttg 163Val Val Gly Ala Thr Gly Gln Val Gly Gln Val Met Arg Thr Leu Leu

10 15 20gaa gag cgc aat ttc cca gct gac act gtt cgt ttc ttt gct tcc cca 211Glu Glu Arg Asn Phe Pro Ala Asp Thr Val Arg Phe Phe Ala Ser Pro

25 30 35cgt tcc gca ggc cgt aag att gaa ttc cgt ggc acg gaa atc gag gta 259Arg Ser Ala Gly Arg Lys Ile Glu Phe Arg Gly Thr Glu Ile Glu Val

40 45 50gaa gac att act cag gca acc gag gag tcc ctc aag gac atc gac gtt 307Glu Asp Ile Thr Gln Ala Thr Glu Glu Ser Leu Lys Asp Ile Asp Val

55 60 65gcg ttg ttc tcc gct gga ggc acc gct tcc aag cag tac gct cca ctg 355Ala Leu Phe Ser Ala Gly Gly Thr Ala Ser Lys Gln Tyr Ala Pro Leu 70 75 80 85ttc gct gct gca ggc gcg act gtt gtg gat aac tct tct gct tgg cgc 403Phe Ala Ala Ala Gly Ala Thr Val Val Asp Asn Ser Ser Ala Trp Arg

90 95 100aag gac gac gag gtt cca cta atc gtc tct gag gtg aac cct tcc gac 451Lys Asp Asp Glu Val Pro Leu Ile Val Ser Glu Val Asn Pro Ser Asp

105 110115aag gat tcc ctg gtc aag ggc att att gcg aac cct aac tgc acc acc 499Lys Asp Ser Leu Val Lys Gly Ile Ile Ala Asn Pro Asn Cys Thr Thr

120 125 130atg gct gcg atg cca gtg ctg aag cca ctt cac gat gcc gct ggt ctt 547Met Ala Ala Met Pro Val Leu Lys Pro Leu His Asp Ala Ala Gly Leu

135 140 145gta aag ctt cac gtt tcc tct tac cag gct gtt tcc ggt tct ggt ctt 595Val Lys Leu His Val Ser Ser Tyr Gln Ala Val Ser Gly Ser Gly Leu150 155 160 165gca ggt gtg gaa acc ttg gca aag cag gtt gct gca gtt gga gac cac 643Ala Gly Val Glu Thr Leu Ala Lys Gln Val Ala Ala Val Gly Asp His

170 175 180aac gtt gag ttc gtc cat gat gga cag gct gct gac gca ggc gat gtc 691Asn Val Glu Phe Val His Asp Gly Gln Ala Ala Asp Ala Gly Asp Val

185 190 195gga cct tat gtt tca cca atc gct tac aac gtg ctg cca ttc gcc gga 739Gly Pro Tyr Val Ser Pro Ile Ala Tyr Asn Val Leu Pro Phe Ala Gly

200 205 210aac ctc gtc gat gac ggc acc ttc gaa acc gat gaa gag cag aag ctg 787Asn Leu Val Asp Asp Gly Thr Phe Glu Thr Asp Glu Glu Gln Lys Leu

215 220 225cgc aac gaa tcc cgc aag att ctc ggt ctc cca gac ctc aag gtc tca 835Arg Asn Glu Ser Arg Lys Ile Leu Gly Leu Pro Asp Leu Lys Val Ser230 235 240 245ggc acc tgc gtc cgc gtg ccg gtt ttc acc ggc cac acg ctg acc att 883Gly Thr Cys Val Arg Val Pro Val Phe Thr Gly His Thr Leu Thr Ile

250 255 260cac gcc gaa ttc gac aag gca atc acc gtg gac cag gcg cag gag ate 931His Ala Glu Phe Asp Lys AlaIle Thr Val Asp Gln Ala Gln Glu Ile

265 270 275ttg ggt gcc gct tca ggc gtc aag ctt gtc gac gtc cca acc cca ctt 979Leu Gly Ala Ala Ser Gly Val Lys Leu Val Asp Val Pro Thr Pro Leu

280 285 290gca gct gcc ggc att gac gaa tcc ctc gtt gga cgc atc cgt cag gac 1027Ala Ala Ala Gly Ile Asp Glu Ser Leu Val Gly Arg Ile Arg Gln Asp

295 300 305tcc act gtc gac gat aac cgc ggt ctg gtt ctc gtc gta tct ggc gac 1075Ser Thr Val Asp Asp Asn Arg Gly Leu Val Leu Val Val Ser Gly Asp310 315 320 325aac ctc cgc aag ggt gct gcg cta aac acc atc cag atc gct gag ctg 1123Asn Leu Arg Lys Gly Ala Ala Leu Asn Thr Ile Gln Ile Ala Glu Leu

330335340 ctg gtt aag taaaaacccg ccattaaaaa ctc 1155Leu Val Lys<210>28<211>344<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>28Met Thr Thr Ile Ala Val Val Gly Ala Thr Gly Gln Val Gly Gln Val 151015 Met Arg Thr Leu Leu Glu Glu Arg Asn Phe Pro Ala Asp Thr Val Arg

20 25 30Phe Phe Ala Ser Pro Arg Ser Ala Gly Arg Lys Ile Glu Phe Arg Gly

35 40 45Thr Glu Ile Glu Val Glu Asp Ile Thr Gln Ala Thr Glu Glu Ser Leu

50 55 60Lys Asp Ile Asp Val Ala Leu Phe Ser Ala Gly Gly Thr Ala Ser Lys 65 70 75 80Gln Tyr Ala Pro Leu Phe Ala Ala Ala Gly Ala Thr Val Val Asp Asn

85 90 95Ser Ser Ala Trp Arg Lys Asp Asp Glu Val Pro Leu Ile Val Ser Glu

100105 110Val Asn Pro Ser Asp Lys Asp Ser Leu Val Lys Gly Ile Ile Ala Asn

115 120 125Pro Asn Cys Thr Thr Met Ala Ala Met Pro Val Leu Lys Pro Leu His

130 135 140Asp Ala Ala Gly Leu Val Lys Leu His Val Ser Ser Tyr Gln Ala Val145 150 155 160Ser Gly Ser Gly Leu Ala Gly Val Glu Thr Leu Ala Lys Gln Val Ala

165 170 175Ala Val Gly Asp His Asn Val Glu Phe Val His Asp Gly Gln Ala Ala

180 185 190Asp Ala Gly Asp Val Gly Pro Tyr Val Ser Pro Ile Ala Tyr Asn Val

195 200 205Leu Pro Phe Ala Gly Asn Leu Val Asp Asp Gly Thr Phe Glu Thr Asp

210 215 220Glu Glu Gln Lys Leu Arg Asn Glu Ser Arg Lys Ile Leu Gly Leu Pro225 230 235 240Asp Leu Lys Val Ser Gly Thr Cys Val Arg Val Pro Val Phe Thr Gly

245 250 255His Thr Leu Thr Ile His Ala Glu Phe Asp Lys Ala Ile Thr Val Asp

260 265 270Gln Ala Gln Glu Ile Leu Gly Ala Ala Ser Gly Val Lys Leu Val Asp

275 280 285Val Pro Thr Pro Leu Ala Ala Ala Gly Ile Asp Glu Ser Leu Val Gly

290 295 300Arg Ile Arg Gln Asp Ser Thr Val Asp Asp Asn Arg Gly Leu Val Leu305 310 315 320Val Val Ser Gly Asp Asn Leu Arg Lys Gly Ala Ala Leu Asn Thr Ile

325 330335Gln Ile Ala Glu Leu Leu Val Lys

340<210>29<211>608<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(69). (608)<223>RXA02843<400>29cccattgcgc ggaggtcgca ccccttccga cttgaactga taggccgata gaaattattc 60tggacgtc atg act act gct tcc gca acc gga att gca aca ctg acc tcc 110

Met Thr Thr Ala Ser Ala Thr Gly Ile Ala Thr Leu Thr Ser

1 5 10acc ggc gac gtc ctg gac gtg tgg tat cca gaa atc ggg tcc acc gac 158Thr Gly Asp Val Leu Asp Val Trp Tyr Pro Glu Ile Gly Ser Thr Asp 15 20 25 30cag tcc gcg ctc aca cct cta gaa ggc gtc gat gaa gat cga aac gtc 206Gln Ser Ala Leu Thr Pro Leu Glu Gly Val Asp Glu Asp Arg Asn Val

35 40 45acc cgc aaa atc gtg acg aca act atc gac acc gac gca gcc ccc acc 254Thr Arg Lys Ile Val Thr Thr Thr Ile Asp Thr Asp Ala Ala Pro Thr

50 55 60gac acc tac gat gca tgg ctg cgc ctt cac ctc ctc tcc cac cgc gtt 302Asp Thr Tyr Asp Ala Trp Leu Arg Leu His Leu Leu Ser His Arg Val

65 70 75ttc cgc cct cac acc arc aac cta gac ggc att ttc ggc ctc ctc aac 350Phe Arg Pro His Thr Ile Asn Leu Asp Gly Ile Phe Gly Leu Leu Asn

80 85 90aat gtc gtg tgg acc aac ttc gga ccg tgc gca gtt gac ggt ttc gca 398Asn Val Val Trp Thr Asn Phe Gly Pro Cys Ala Val Asp Gly Phe Ala 95 100 105 110ctc acc cgc gcg cgc ctg tca cgc cga ggc caa gtt acg gtt tat agc 446Leu Thr Arg Ala Arg Leu Ser Arg Arg Gly Gln Val Thr Val Tyr Ser

115 120 125gtc gac aag ttc cca cgc atg gtc gac tat gtg gtt ccc tcg ggc gtg 494Val Asp Lys Phe Pro Arg Met Val Asp Tyr Val Val Pro Ser Gly Val

130 135 140cgc atc ggt gac gcc gac cgc gtc cga ctt ggc gcg tac ctg gca gat 542Arg Ile Gly Asp Ala Asp Arg Val Arg Leu Gly Ala Tyr Leu Ala Asp

145 150 155ggc acc acc gtg atg cat gag ggc ttc gtg aac ttc aac gct ggc acg 590Gly Thr Thr Val Met His Glu Gly Phe Val Asn Phe Asn Ala Gly Thr

160165170 ctc ggc gct tcc atg gtt 608Leu Gly Ala Ser Met Val 175180<210>30<211>180<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>30Met Thr Thr Ala Ser Ala Thr Gly Ile Ala Thr Leu Thr Ser Thr Gly 151015 Asp Val Leu Asp Val Trp Tyr Pro Glu Ile Gly Ser Thr Asp Gln Ser

20 25 30Ala Leu Thr Pro Leu Glu Gly Val Asp Glu Asp Arg Asn Val Thr Arg

35 40 45Lys Ile Val Thr Thr Thr Ile Asp Thr Asp Ala Ala Pro Thr Asp Thr

50 55 60Tyr Asp Ala Trp Leu Arg Leu His Leu Leu Ser His Arg Val Phe Arg 65 70 75 80Pro His Thr Ile Asn Leu Asp Gly Ile Phe Gly Leu Leu Asn Asn Val

85 90 95Val Trp Thr Asn Phe Gly Pro Cys Ala Val Asp Gly Phe Ala Leu Thr

100 105 110Arg Ala Arg Leu Ser Arg Arg Gly Gln Val Thr Val Tyr Ser Val Asp

115 120 125Lys Phe Pro Arg Met Val Asp Tyr Val Val Pro Ser Gly Val Arg Ile

130 135 140Gly Asp Ala Asp Arg Val Arg Leu Gly Ala Tyr Leu Ala Asp Gly Thr145 150 155 160Thr Val Met His Glu Gly Phe Val Asn Phe Asn Ala Gly Thr Leu Gly

165 170 175Ala Ser Met Val

180<210>31<211>1230<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1207)<223>RXA02022<400>31tatttgcgat tccaactgct tgggctccgc gaatgttttc actcattttt taatcgaccg 60cttccatcat gttttaacta aggtttgtag gcttaaacct gtg aac tct gaa ctc 115

Val Asn Ser Glu Leu

1 5aaa cca gga tta gat ctc ctc ggc gac cca att gtc ctt act caa cgt 163Lys Pro Gly Leu Asp Leu Leu Gly Asp Pro Ile Val Leu Thr Gln Arg

10 15 20ttg gta gat ata ccg agt ccg tcg ggt cag gaa aag cag att gct gat 211Leu Val Asp Ile Pro Ser Pro Ser Gly Gln Glu Lys Gln Ile Ala Asp

25 30 35gaa att gaa gat gcc ctt cgg aac ctt aat cta cct ggt gta gag gtc 259Glu Ile Glu Asp Ala Leu Arg Asn Leu Asn Leu Pro Gly Val Glu Val

40 45 50ttc cgc ttc aac aac aac gtt ctt gct cgc acg aac agg gga ttg gcc 307Phe Arg Phe Asn Asn Asn Val Leu Ala Arg Thr Asn Arg Gly Leu Ala

55 60 65tcg agg gtc atg ctt gct ggt cat atc gat aca gtg ccg atc gcg gac 355Ser Arg Val Met Leu Ala Gly His Ile Asp Thr Val Pro Ile Ala Asp 70 75 80 85aat ctg cca agc cgt gtg gaa gac ggc atc atg tat ggc tgt ggc acc 403Asn Leu Pro Ser Arg Val Glu Asp Gly Ile Met Tyr Gly Cys Gly Thr

90 95 100 gtc gat atg aaa tct ggg ttg gcg gtg tat ttg cat act ttt gcc acc 451Val Asp Met Lys Ser Gly Leu Ala Val Tyr Leu His Thr Phe Ala Thr

105 110 115ttg gcc acg tcg act gag ctt aaa cat gat ctg acg ctg att gcg tat 499Leu Ala Thr Ser Thr Glu Leu Lys His Asp Leu Thr Leu Ile Ala Tyr

120 125 130gag tgc gag gaa gtt gct gat cac ctc aat ggt ttg ggc cac att cgc 547Glu Cys Glu Glu Val Ala Asp His Leu Asn Gly Leu Gly His Ile Arg

135 140 145gat gag cat ccg gag tgg ttg gcg gct gat ttg gcg ttg ttg ggt gag 595Asp Glu His Pro Glu Trp Leu Ala Ala Asp Leu Ala Leu Leu Gly Glu150 155 160 165cct act ggc ggc tgg att gag gcg ggc tgc cag ggc aat ctg cgc atc 643Pro Thr Gly Gly Trp Ile Glu Ala Gly Cys Gln Gly Asn Leu Arg Ile

170 175 180aag gtg acg gcg cat ggt gtg cgt gcc cat tcg gcg aga agc tgg ttg 691Lys Val Thr Ala His Gly Val Arg Ala His Ser Ala Arg Ser Trp Leu

185 190 195ggt gat aat gcg atg cat aag ttg tcg ccg atc att tcg aag gtt gct 739Gly Asp Asn Ala Met His Lys Leu Ser Pro Ile Ile Ser Lys Val Ala

200 205 210gcg tat aag gcc gca gaa gtc aac att gat ggc ttg acc tac cgt gaa 787Ala Tyr Lys Ala Ala Glu Val Asn Ile Asp Gly Leu Thr Tyr Arg Glu

215 220 225ggc ctc aac atc gtt ttc tgc gaa tcg ggc gtg gca aac aac gtc att 835Gly Leu Asn Ile Val Phe Cys Glu Ser Gly Val Ala Asn Asn Val Ile230235 240 245cca gac ctc gcg tgg atg aac ctc aac ttc cgt ttc gcg ccg aat cgc 883Pro Asp Leu Ala Trp Met Asn Leu Asn Phe Arg Phe Ala Pro Asn Arg

250 255 260gat ctc aac gag gcg atc gag cat gtc gtc gaa acg ctt gag ctt gac 931Asp Leu Asn Glu Ala Ile Glu His Val Val Glu Thr Leu Glu Leu Asp

265 270 275ggt caa gac ggc atc gaa tgg gcc gta gaa gac ggg gca ggc ggt gcc 979Gly Gln Asp Gly Ile Glu Trp Ala ValGlu Asp Gly Ala Gly Gly Ala

280 285 290ctt cca ggc ttg ggg cag cag gtg aca agc ggg ctt atc gac gcc gtc 1027Leu Pro Gly Leu Gly Gln Gln Val Thr Ser Gly Leu Ile Asp Ala Val

295 300 305ggc cgc gaa aaa atc cgc gca aaa ttc ggc tgg acc gat gtc tca cgt 1075Gly Arg Glu Lys Ile Arg Ala Lys Phe Gly Trp Thr Asp Val Ser Arg310 315 320 325ttt tca gcc atg gga att cca gcc cta aac ttt ggc gct ggt gat cca 1123Phe Ser Ala Met Gly Ile Pro Ala Leu Asn Phe Gly Ala Gly Asp Pro

330 335 340agt ttc gcg cat aaa cgc gac gag cag tgc cca gtg gag caa atc acg 1171Ser Phe Ala His Lys Arg Asp Glu Gln Cys Pro Val Glu Gln Ile Thr

345 350 355gat gtg gca gca att ttg aag cag tac ctg agc gag taaccgcatt 1217Asp Val Ala Ala Ile Leu Lys Gln Tyr Leu Ser Glu

360365 cggggttatc gtg 1230<210>32<211>369<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>32Val Asn Ser Glu Leu Lys Pro Gly Leu Asp Leu Leu Gly Asp Pro Ile 151015 Val Leu Thr Gln Arg Leu Val Asp Ile Pro Ser Pro Ser Gly Gln Glu

20 25 30Lys Gln Ile Ala Asp Glu Ile Glu Asp Ala Leu Arg Asn Leu Asn Leu

35 40 45Pro Gly Val Glu Val Phe Arg Phe Asn Asn Asn Val Leu Ala Arg Thr

50 55 60Asn Arg Gly Leu Ala Ser Arg Val Met Leu Ala Gly His Ile Asp Thr 65 70 75 80Val Pro Ile Ala Asp Asn Leu Pro Ser Arg Val Glu Asp Gly Ile Met

85 90 95Tyr Gly Cys Gly Thr Val Asp Met Lys Ser Gly Leu Ala Val Tyr Leu

100 105 110His Thr Phe Ala Thr Leu Ala Thr Ser Thr Glu Leu Lys His Asp Leu

115 120 125Thr Leu Ile Ala Tyr Glu Cys Glu Glu Val Ala Asp His Leu Asn Gly

130 135 140Leu Gly His Ile Arg Asp Glu His Pro Glu Trp Leu Ala Ala Asp Leu145 150 155 160Ala Leu Leu Gly Glu Pro Thr Gly Gly Trp Ile Glu Ala Gly Cys Gln

165 170 175Gly Asn Leu Arg Ile Lys Val Thr Ala His Gly Val Arg Ala His Ser

180 185 190Ala Arg Ser Trp Leu Gly Asp Asn Ala Met His Lys Leu Ser Pro Ile

195 200 205Ile Ser Lys Val Ala Ala Tyr Lys Ala Ala Glu Val Asn Ile Asp Gly

210 215 220Leu Thr Tyr Arg Glu Gly Leu Asn Ile Val Phe Cys Glu Ser Gly Val225 230 235 240Ala Asn Asn Val Ile Pro Asp Leu Ala Trp Met Asn Leu Asn Phe Arg

245 250 255Phe Ala Pro Asn Arg Asp Leu Asn Glu Ala Ile Glu His Val Val Glu

260 265 270Thr Leu Glu Leu Asp Gly Gln Asp Gly Ile Glu Trp Ala Val Glu Asp

275 280 285Gly Ala Gly Gly Ala Leu Pro Gly Leu Gly Gln Gln Val Thr Ser Gly

290 295 300Leu Ile Asp Ala Val Gly Arg Glu Lys Ile Arg Ala Lys Phe Gly Trp305 310 315 320Thr Asp Val Ser Arg Phe Ser Ala Met Gly Ile Pro Ala Leu Asn Phe

325 330 335Gly Ala Gly Asp Pro Ser Phe Ala His Lys Arg Asp Glu Gln Cys Pro

340 345 350

Val Glu Gln Ile Thr Asp Val Ala Ala Ile Leu Lys Gln Tyr Leu Ser

355360365 Glu<210>33<211>1059<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1036)<223>RXA00044<400>33attacctcag ccttccaagc tgatgatgca ttacttaaaa actgcagaca cttgaaaaac 60ttctcacccg cactcgttcc ctcaacccac aaggagcacc atg gct tcc gca act 115

Met Ala Ser Ala Thr

1 5ttc acc ggc gtg atc cca ccc gta atg acc cca ctc cac gcc gac ggc 163Phe Thr Gly Val Ile Pro Pro Val Met Thr Pro Leu His Ala Asp Gly

10 15 20agt gtg gat gta gaa agc ctc cgc aag ctc gtt gac cac ctc atc aat 211Ser Val Asp Val Glu Ser Leu Arg Lys Leu Val Asp His Leu Ile Asn

25 3035ggt ggc gtc gac gga ctt ttc gca ctg ggc tcc tca ggc gaa gcg gca 259Gly Gly Val Asp Gly Leu Phe Ala Leu Gly Ser Ser Gly Glu Ala Ala

40 45 50ttc ctc acc cgc gcc cag cgc aaa ctc gca ctg acc acc atc atc gag 307Phe Leu Thr Arg Ala Gln Arg Lys Leu Ala Leu Thr Thr Ile Ile Glu

55 60 65cac acc gca ggc cgc gtt ccc gta act gct ggt gtc att gaa acc acc 355His Thr Ala Gly Arg Val Pro Val Thr Ala Gly Val Ile Glu Thr Thr 70 75 80 85act gct cgc gtg att gag ctc gtg gaa gat gcc ctg gag gct ggt gcc 403Thr Ala Arg Val Ile Glu Leu Val Glu Asp Ala Leu Glu Ala Gly Ala

90 95 100gaa ggc ctc gtt gcc act gca cct ttc tac acc cgc acc cac gat gtg 451Glu Gly Leu Val Ala Thr Ala Pro Phe Tyr Thr Arg Thr His Asp Val

105 110 115gaa att gaa gaa cacttc cgc aag atc cac gcc gcc gct cca gag ctt 499Glu Ile Glu Glu His Phe Arg Lys Ile His Ala Ala Ala Pro Glu Leu

120 125 130cca ctg ttt gcc tac aac atc cca gtg tcg gtg cac tcc aac ctc aac 547Pro Leu Phe Ala Tyr Asn Ile Pro Val Ser Val His Ser Asn Leu Asn

135 140 145cca gtc atg ctt ttg acg ctg gcc aag gat ggc gtt ctt gca ggc acc 595Pro Val Met Leu Leu Thr Leu Ala Lys Asp Gly Val Leu Ala Gly Thr150 155 160 165aag gat tcc agt ggc aat gat ggc gca atc cgc tca ctg atc gaa gct 643Lys Asp Ser Ser Gly Asn Asp Gly Ala Ile Arg Ser Leu Ile Glu Ala

170 175 180cgt gat gat gct gga ctc act gag cag ttc aag atc ctc acc ggc agc 691Arg Asp Asp Ala Gly Leu ThrGlu Gln Phe Lys Ile Leu Thr Gly Ser

185 190 195gaa acc acc gtt gat ttc gcc tac ctt gcg ggt gcc gat gga gtt gtc 739Glu Thr Thr Val Asp Phe Ala Tyr Leu Ala Gly Ala Asp Gly Val Val

200 205 210cca ggc ctg ggc aat gtt gat cct gca gca tac gca gct tta gca aaa 787Pro Gly Leu Gly Asn Val Asp Pro Ala Ala Tyr Ala Ala Leu Ala Lys

215 220 225ctc tgc ctc gat gga aag tgg gca gaa gct gct gct ttg cag aag cgc 835Leu Cys Leu Asp Gly Lys Trp Ala Glu Ala Ala Ala Leu Gln Lys Arg230 235 240 245atc aac cac ctc ttc cac atc gtc ttc gtg gga gac acc tcc cat atg 883Ile Asn His Leu Phe His Ile Val Phe Val Gly Asp Thr Ser His Met

250 255 260tcc gga tcc agc gct ggt ttg ggc ggt ttc aag aca gca ctc gca cac 931Ser Gly Ser Ser Ala Gly Leu Gly Gly Phe Lys Thr Ala Leu Ala His

265 270 275ctt ggc att att gaa tcc aat gcg atg gca gtt cct cac cag agc ctc 979Leu Gly Ile Ile Glu Ser Asn Ala Met Ala Val Pro His Gln Ser Leu

280 285 290agc gac gaa gaa act gct cgc att cac gcc att gtt gat gaa ttc ctg 1027Ser Asp Glu Glu Thr Ala Arg Ile His Ala Ile Val Asp Glu Phe Leu

295300305 tac acc gct taaggcccac acctcatgac tga 1059Tyr Thr Ala310<210>34<211>312<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>34Met Ala Ser Ala Thr Phe Thr Gly Val Ile Pro Pro Val Met Thr Pro 151015 Leu His Ala Asp Gly Ser Val Asp Val Glu Ser Leu Arg Lys Leu Val

20 25 30Asp His Leu Ile Asn Gly Gly Val Asp Gly Leu Phe Ala Leu Gly Ser

35 40 45Ser Gly Glu Ala Ala Phe Leu Thr Arg Ala Gln Arg Lys Leu Ala Leu

50 55 60Thr Thr Ile Ile Glu His Thr Ala Gly Arg Val Pro Val Thr Ala Gly 65 70 75 80Val Ile Glu Thr Thr Thr Ala Arg Val Ile Glu Leu Val Glu Asp Ala

85 90 95Leu Glu Ala Gly Ala Glu Gly Leu Val Ala Thr Ala Pro Phe Tyr Thr

100 105 110Arg Thr His Asp Val Glu Ile Glu Glu His Phe Arg Lys Ile His Ala

115 120 125Ala Ala Pro Glu Leu Pro Leu Phe Ala Tyr Asn Ile Pro Val Ser Val

130 135 140His Ser Asn Leu Asn Pro Val Met Leu Leu Thr Leu Ala Lys Asp Gly145 150 155 160Val Leu Ala Gly Thr Lys Asp Ser Ser Gly Asn Asp Gly Ala Ile Arg

165 170 175Ser Leu Ile Glu Ala Arg Asp Asp Ala Gly Leu Thr Glu Gln Phe Lys

180 185 190Ile Leu Thr Gly Ser Glu Thr Thr Val Asp Phe Ala Tyr Leu Ala Gly

195 200 205Ala Asp Gly Val Val Pro Gly Leu Gly Asn Val Asp Pro Ala Ala Tyr

210 215 220Ala Ala Leu Ala Lys Leu Cys Leu Asp Gly Lys Trp Ala Glu Ala Ala225 230 235 240Ala Leu Gln Lys Arg Ile Asn His Leu Phe His Ile Val Phe Val Gly

245 250 255Asp Thr Ser His Met Ser Gly Ser Ser Ala Gly Leu Gly Gly Phe Lys

260 265 270Thr Ala Leu Ala His Leu Gly Ile Ile Glu Ser Asn Ala Met Ala Val

275 280 285Pro His Gln Ser Leu Ser Asp Glu Glu Thr Ala Arg Ile His Ala Ile

290295300 Val Asp Glu Phe Leu Tyr Thr Ala 305310<210>35<211>867<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) · (844)<223>RXA00863<400>35aacggtcagt taggtatgga tatcagcacc ttctgaacgg gtacgtctag actggtgggc 60gtttgaaaaa ctcttcgccc cacgaaaatg aaggagcata atg gga atc aag gtt 115

Met Gly Ile Lys Val

1 5ggc gtt ctc gga gcc aaa ggc cgt gtt ggt caa act att gtg gca gca 163Gly Val Leu Gly Ala Lys Gly Arg Val Gly Gln Thr Ile Val Ala Ala

10 15 20gtc aat gag tcc gac gat ctg gag ctt gtt gca gag atc ggc gtc gac 211Val Asn Glu Ser Asp Asp Leu Glu Leu Val Ala Glu Ile Gly Val Asp

25 30 35gat gat ttg agc ctt ctg gta gac aac ggc gct gaa gtt gtc gtt gac 259Asp Asp Leu Ser Leu Leu Val Asp Asn Gly Ala Glu Val Val Val Asp

40 45 50ttc acc act cct aac gct gtg atg ggc aac ctg gag ttc tgc atc aac 307Phe Thr Thr Pro Asn Ala Val Met Gly Asn Leu Glu Phe Cys Ile Asn

55 60 65aac ggc att tct gcg gtt gtt gga acc acg ggc ttc gat gat gct cgt 355Asn Gly Ile Ser Ala Val Val Gly Thr Thr Gly Phe Asp Asp Ala Arg 70 75 80 85ttg gag cag gtt cgc gac tgg ctt gaa gga aaa gac aat gtc ggt gtt 403Leu Glu Gln Val Arg Asp Trp Leu Glu Gly Lys Asp Asn Val Gly Val

90 95 100ctg atc gca cct aac ttt gct atc tct gcg gtg ttg acc atg gtc ttt 451Leu Ile Ala Pro Asn Phe Ala Ile Ser Ala Val Leu Thr Met Val Phe

105 110 115tcc aag cag gct gcc cgc ttc ttc gaa tca gct gaa gtt att gag ctg 499Ser Lys Gln Ala Ala Arg Phe Phe Glu Ser Ala Glu Val Ile Glu Leu

120 125 130cac cac ccc aac aag ctg gat gca cct tca ggc acc gcg atc cac act 547His His Pro Asn Lys Leu Asp Ala Pro Ser Gly Thr Ala Ile His Thr

135 140 145gct cag ggc att gct gcg gca cgc aaa gaa gca ggc atg gac gca cag 595Ala Gln Gly Ile Ala Ala Ala Arg Lys Glu Ala Gly Met Asp Ala Gln150 155 160 165cca gat gcg acc gag cag gca ctt gag ggt tcc cgt ggc gca agc gta 643Pro Asp Ala Thr Glu Gln Ala Leu Glu Gly Ser Arg Gly Ala Ser Val

170 175 180gat gga atc ccg gtt cat gca gtc cgc atg tcc ggc atg gtt gct cac 691Asp Gly Ile Pro Val His Ala Val Arg Met Ser Gly Met Val Ala His

185 190 195gag caa gtt atc ttt ggc acc cag ggt cag acc ttg acc atc aag cag 739Glu Gln Val Ile Phe Gly Thr Gln Gly Gln Thr Leu Thr Ile Lys Gln

200 205 210gac tcc tat gat cgc aac tca ttt gca cca ggt gtc ttg gtg ggt gtg 787Asp Ser Tyr Asp Arg Asn Ser Phe Ala Pro Gly Val Leu Val Gly Val

215220225 cgc aac att gca cag cac cca ggc cta gtc gta gga ctt gag cat tac 835Arg Asn Ile Ala Gln His Pro Gly Leu Val Val Gly Leu Glu His Tyr 230235240245 cta ggc ctg taaaggctca tttcagcagc ggg867Leu Gly Leu<210>36<211>248<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>36Met Gly Ile Lys Val Gly Val Leu Gly Ala Lys Gly Arg Val Gly Gln 151015 Thr Ile Val Ala Ala Val Asn Glu Ser Asp Asp Leu Glu Leu Val Ala

20 25 30Glu Ile Gly Val Asp Asp Asp Leu Ser Leu Leu Val Asp Asn Gly Ala

35 40 45Glu Val Val Val Asp Phe Thr Thr Pro Asn Ala Val Met Gly Asn Leu

50 55 60Glu Phe Cys Ile Asn Asn Gly Ile Ser Ala Val Val Gly Thr Thr Gly 65 70 75 80Phe Asp Asp Ala Arg Leu Glu Gln Val Arg Asp Trp Leu Glu Gly Lys

85 90 95Asp Asn Val Gly Val Leu Ile Ala Pro Asn Phe Ala Ile Ser Ala Val

100 105 110Leu Thr Met Val Phe Ser Lys Gln Ala Ala Arg Phe Phe Glu Ser Ala

115 120 125Glu Val Ile Glu Leu His His Pro Asn Lys Leu Asp Ala Pro Ser Gly

130 135 140Thr Ala Ile His Thr Ala Gln Gly Ile Ala Ala Ala Arg Lys Glu Ala145 150 155 160Gly Met Asp Ala Gln Pro Asp Ala Thr Glu Gln Ala Leu Glu Gly Ser

165 170 175Arg Gly Ala Ser Val Asp Gly Ile Pro Val His Ala Val Arg Met Ser

180 185 190Gly Met Val Ala His Glu Gln Val Ile Phe Gly Thr Gln Gly Gln Thr

195 200 205Leu Thr Ile Lys Gln Asp Ser Tyr Asp Arg Asn Ser Phe Ala Pro Gly

210 215 220Val Leu Val Gly Val Arg Asn Ile Ala Gln His Pro Gly Leu Val Val225 230 235 240Gly Leu Glu His Tyr Leu Gly Leu

245<210>37<211>873<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (850)<223>RXA00864<400>37acagcaccca ggcctagtcg taggacttga gcattaccta ggcctgtaaa ggctcatttc 60agcagcgggt ggaatttttt aaaaggagcg tttaaaggct gtg gcc gaa caa gtt 115

Val Ala Glu Gln Val

1 5aaa ttg agc gtg gag ttg ata gcg tgc agt tct ttt act cca ccc gct 163Lys Leu Ser Val Glu Leu Ile Ala Cys Ser Ser Phe Thr Pro Pro Ala

10 15 20gat gtt gag tgg tca act gat gtt gag ggc gcg gaa gca ctc gtc gag 211Asp Val Glu Trp Ser Thr Asp Val Glu Gly Ala Glu Ala Leu Val Glu

25 30 35ttt gcg ggt cgt gcc tgc tac gaa act ttt gat aag ccg aac cct cga 259Phe Ala Gly Arg Ala Cys Tyr Glu Thr Phe Asp Lys Pro Asn Pro Arg

40 45 50act gct tcc aat gct gcg tat ctg cgc cac atc atg gaa gtg ggg cac 307Thr Ala Ser Asn Ala Ala Tyr Leu Arg His Ile Met Glu Val Gly His

55 60 65act gct ttg ctt gag cat gcc aat gcc acg atg tat atc cga ggc att 355Thr Ala Leu Leu Glu His Ala Asn Ala Thr Met Tyr Ile Arg Gly Ile 70 75 80 85tct cgg tcc gcg acc cat gaa ttg gtc cga cac cgc cat ttt tcc ttc 403Ser Arg Ser Ala Thr His Glu Leu Val Arg His Arg His Phe Ser Phe

90 95 100tct caa ctg tct cag cgt ttc gtg cac agc gga gaa tcg gaa gta gtg 451Ser Gln Leu Ser Gln Arg Phe Val His Ser Gly Glu Ser Glu Val Val

105 110 115gtg ccc act ctc atc gat gaa gat ccg cag ttg cgt gaa ctt ttc atg 499Val Pro Thr Leu Ile Asp Glu Asp Pro Gln Leu Arg Glu Leu Phe Met

120 125 130cac gcc atg gat gag tct cgg ttc gct ttc aat gag ctg ctt aat gcg 547His Ala Met Asp Glu Ser Arg Phe Ala Phe Asn Glu Leu Leu Asn Ala

135 140 145ctg gaa gaa aaa ctt ggc gat gaa ccg aat gca ctt tta agg aaa aag 595Leu Glu Glu Lys Leu Gly Asp Glu Pro Asn Ala Leu Leu Arg Lys Lys150 155 160 165cag gct cgt caa gca gct cgc gct gtg ctg ccc aac gct aca gag tcc 643Gln Ala Arg Gln Ala Ala Arg Ala Val Leu Pro Asn Ala Thr Glu Ser

170 175 180aga atc gtg gtg tct gga aac ttc cgc acc tgg agg cat ttc att ggc 691Arg Ile Val Val Ser Gly Asn Phe Arg Thr Trp Arg His Phe Ile Gly

185 190 195atg cga gcc agt gaa cat gca gac gtc gaa atc cgc gaa gta gcg gta 739Met Arg Ala Ser Glu His Ala Asp Val Glu Ile Arg Glu Val Ala Val

200 205 210gaa tgt tta aga aag ctg cag gta gca gcg cca act gtt ttc ggt gat 787Glu Cys Leu Arg Lys Leu Gln Val Ala Ala Pro Thr Val Phe Gly Asp

215 220 225ttt gag att gaa act ttg gca gac gga tcg caa atg gca aca agc ccg 835Phe Glu Ile Glu Thr Leu Ala Asp Gly Ser Gln Met Ala Thr Ser Pro230 235 240 245tat gtc atg gac ttt taacgcaaag ctcacaccca cga873Tyr Val Met Asp Phe

250<210>38<211>250<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>38Val Ala Glu Gln Val Lys Leu Ser Val Glu Leu Ile Ala Cys Ser Ser 151015 Phe Thr Pro Pro Ala Asp Val Glu Trp Ser Thr Asp Val Glu Gly Ala

20 25 30Glu Ala Leu Val Glu Phe Ala Gly Arg Ala Cys Tyr Glu Thr Phe Asp

35 40 45Lys Pro Asn Pro Arg Thr Ala Ser Asn Ala Ala Tyr Leu Arg His Ile

50 55 60Met Glu Val Gly His Thr Ala Leu Leu Glu His Ala Asn Ala Thr Met 65 70 75 80Tyr Ile Arg Gly Ile Ser Arg Ser Ala Thr His Glu Leu Val Arg His

85 90 95Arg His Phe Ser Phe Ser Gln Leu Ser Gln Arg Phe Val His Ser Gly

100 105 110Glu Ser Glu Val Val Val Pro Thr Leu Ile Asp Glu Asp Pro Gln Leu

115 120 125Arg Glu Leu Phe Met His Ala Met Asp Glu Ser Arg Phe Ala Phe Asn

130 135 140Glu Leu Leu Asn Ala Leu Glu Glu Lys Leu Gly Asp Glu Pro Asn Ala145 150 155 160Leu Leu Arg Lys Lys Gln Ala Arg Gln Ala Ala Arg Ala Val Leu Pro

165 170 175Asn Ala Thr Glu Ser Arg Ile Val Val Ser Gly Asn Phe Arg Thr Trp

180 185 190Arg His Phe Ile Gly Met Arg Ala Ser Glu His Ala Asp Val Glu Ile

195 200 205Arg Glu Val Ala ValGlu Cys Leu Arg Lys Leu Gln Val Ala Ala Pro

210 215 220Thr Val Phe Gly Asp Phe Glu Ile Glu Thr Leu Ala Asp Gly Ser Gln225 230 235 240Met Ala Thr Ser Pro Tyr Val Met Asp Phe

245250<210>39<211>608<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(69) } (608)<223>RXA02843<400>39cccattgcgc ggaggtcgca ccccttccga cttgaactga taggccgata gaaattattc 60tggacgtc atg act act gct tcc gca acc gga att gca aca ctg acc tcc 110

Met Thr Thr Ala Ser Ala Thr Gly Ile Ala Thr Leu Thr Ser

1 5 10acc ggc gac gtc ctg gac gtg tgg tat cca gaa atc ggg tcc acc gac 158Thr Gly Asp Val Leu Asp Val Trp Tyr Pro Glu Ile Gly Ser Thr Asp 15 20 25 30cag tcc gcg ctc aca cct cta gaa ggc gtc gat gaa gat cga aac gtc 206Gln Ser Ala Leu Thr Pro Leu Glu Gly Val Asp Glu Asp Arg Asn Val

35 40 45acc cgc aaa atc gtg acg aca act atc gac acc gac gca gcc ccc acc 254Thr Arg Lys Ile Val Thr Thr Thr Ile Asp Thr Asp Ala Ala Pro Thr

50 55 60gac acc tac gat gca tgg ctg cgc ctt cac ctc ctc tcc cac cgc gtt 302Asp Thr Tyr Asp Ala Trp Leu Arg Leu His Leu Leu Ser His Arg Val

65 70 75ttc cgc cct cac acc atc aac cta gac ggc att ttc ggc ctc ctc aac 350Phe Arg Pro His Thr Ile Asn Leu Asp Gly Ile Phe Gly Leu Leu Asn

80 85 90aat gtc gtg tgg acc aac ttc gga ccg tgc gca gtt gac ggt ttc gca 398Asn Val Val Trp Thr Asn Phe Gly Pro Cys Ala Val Asp Gly Phe Ala 95 100 105 110ctc acc cgc gcg cgc ctg tca cgc cga ggc caa gtt acg gtt tat agc 446Leu Thr Arg Ala Arg Leu Ser Arg Arg Gly Gln Val Thr Val Tyr Ser

115 120 125gtc gac aag ttc cca cgc atg gtc gac tat gtg gtt ccc tcg ggc gtg 494Val Asp Lys Phe Pro Arg Met Val Asp Tyr Val Val Pro Ser Gly Val

130 135 140cgc atc ggt gac gcc gac cgc gtc cga ctt ggc gcg tac ctg gca gat 542Arg Ile Gly Asp Ala Asp Arg Val Arg Leu Gly Ala Tyr Leu Ala Asp

145 150 155ggc acc acc gtg atg cat gag ggc ttc gtg aac ttc aac gct ggc acg 590Gly Thr Thr Val Met His Glu Gly Phe Val Asn Phe Asn Ala Gly Thr

160165170 ctc ggc gct tcc atg gtt 608Leu Gly Ala Ser Met Val 175180<210>40<211>180<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>40Met Thr Thr Ala Ser Ala Thr Gly Ile Ala Thr Leu Thr Ser Thr Gly 151015 Asp Val Leu Asp Val Trp Tyr Pro Glu Ile Gly Ser Thr Asp Gln Ser

20 25 30Ala Leu Thr Pro Leu Glu Gly Val Asp Glu Asp Arg Asn Val Thr Arg

35 40 45Lys Ile Val Thr Thr Thr Ile Asp Thr Asp Ala Ala Pro Thr Asp Thr

50 55 60Tyr Asp Ala Trp Leu Arg Leu His Leu Leu Ser His Arg Val Phe Arg 65 70 75 80Pro His Thr Ile Asn Leu Asp Gly Ile Phe Gly Leu Leu Asn Asn Val

85 90 95Val Trp Thr Asn Phe Gly Pro Cys Ala Val Asp Gly Phe Ala Leu Thr

100105 110Arg Ala Arg Leu Ser Arg Arg Gly Gln Val Thr Val Tyr Ser Val Asp

115 120 125Lys Phe Pro Arg Met Val Asp Tyr Val Val Pro Ser Gly Val Arg Ile

130 135 140Gly Asp Ala Asp Arg Val Arg Leu Gly Ala Tyr Leu Ala Asp Gly Thr145 150 155 160Thr Val Met His Glu Gly Phe Val Asn Phe Asn Ala Gly Thr Leu Gly

165 170 175Ala Ser Met Val

180<210>41<211>1143<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1120)<223>RXN00355<400>41aatagatcag cgcatccgtg gtggaaccaa aaggctcaac aatacgaaac gttcgctttc 60ggtcctgatg aaagagatgt ccctgaatca tcatctaagt atg cat ctc ggt aag 115

Met His Leu Gly Lys

1 5ctc gac cag gac agt gcc acc aca att ttg gag gat tac aag aac atg 163Leu Asp Gln Asp Ser Ala Thr Thr Ile Leu Glu Asp Tyr Lys Asn Met

10 15 20acc aac atc cgc gta gct atc gtg ggc tac gga aac ctg gga cgc agc 211Thr Asn Ile Arg Val Ala Ile Val Gly Tyr Gly Asn Leu Gly Arg Ser

25 30 35gtc gaa aag ctt att gcc aag cag ccc gac atg gac ctt gta gga atc 259Val Glu Lys Leu Ile Ala Lys Gln Pro Asp Met Asp Leu Val Gly Ile

40 45 50ttc tcg cgc cgg gcc acc ctc gac aca aag acg cca gtc ttt gat gtc 307Phe Ser Arg Arg Ala Thr Leu Asp Thr Lys Thr Pro Val Phe Asp Val

5560 65gcc gac gtg gac aag cac gcc gac gac gtg gac gtg ctg ttc ctg tgc 355Ala Asp Val Asp Lys His Ala Asp Asp Val Asp Val Leu Phe Leu Cys 70 75 80 85atg ggc tcc gcc acc gac atc cct gag cag gca cca aag ttc gcg cag 403Met Gly Ser Ala Thr Asp Ile Pro Glu Gln Ala Pro Lys Phe Ala Gln

90 95 100ttc gcc tgc acc gta gac acc tac gac aac cac cgc gac atc cca cgc 451Phe Ala Cys Thr Val Asp Thr Tyr Asp Asn His Arg Asp Ile Pro Arg

105 110 115cac cgc cag gtc atg aac gaa gcc gcc acc gca gcc ggc aac gtt gca 499His Arg Gln Val Met Asn Glu Ala Ala Thr Ala Ala Gly Asn Val Ala

120 125 130ctg gtc tct acc ggc tgg gat cca gga atg ttc tcc atc aac cgc gtc 547Leu Val Ser Thr Gly Trp Asp Pro Gly Met Phe Ser Ile Asn Arg Val

135 140 145tac gca gcg gca gtc tta gcc gag cac cag cag cac acc ttc tgg ggc 595Tyr Ala Ala Ala Val Leu Ala Glu His Gln Gln His Thr Phe Trp Gly150 155 160 165cca ggt ttg tca cag ggc cac tcc gat gct ttg cga cgc atc cct ggc 643Pro Gly Leu Ser Gln Gly His Ser Asp Ala Leu Arg Arg Ile Pro Gly

170 175 180gtt caa aag gca gtc cag tac acc ctc cca tcc gaa gac gcc ctg gaa 691Val Gln Lys Ala Val Gln Tyr Thr Leu Pro Ser Glu Asp Ala Leu Glu

185 190 195aag gcc cgc cgc ggc gaa gcc ggc gac ctt acc gga aag caa acc cac 739Lys Ala Arg Arg Gly Glu Ala Gly Asp Leu Thr Gly Lys Gln Thr His

200 205 210aag cgc caa tgc ttc gtg gtt gcc gac gcg gcc gat cac gag cgc atc 787LysArg Gln Cys Phe Val Val Ala Asp Ala Ala Asp His Glu Arg Ile

215 220 225gaa aac gac atc cgc acc atg cct gat tacttc gtt ggc tac gaa gtc 835Glu Asn Asp Ile Arg Thr Met Pro Asp Tyr Phe Val Gly Tyr Glu Val230 235 240 245gaa gtc aac ttc atc gac gaa gca acc ttc gac tcc gag cac acc ggc 883Glu Val Asn Phe Ile Asp Glu Ala Thr Phe Asp Ser Glu His Thr Gly

250 255 260atg cca cac ggt ggc cac gtg att acc acc ggc gac acc ggt ggc ttc 931Met Pro His Gly Gly His Val Ile Thr Thr Gly Asp Thr Gly Gly Phe

265 270 275aac cac acc gtg gaa tac atc ctc aag ctg gac cga aac cca gat ttc 979Asn His Thr Val Glu Tyr Ile Leu Lys Leu Asp Arg Asn Pro Asp Phe

280 285 290acc gct tcc tca cag atc gct ttc ggt cgc gca gct cac cgc atg aag 1027Thr Ala Ser Ser Gln Ile Ala Phe Gly Arg Ala Ala His Arg Met Lys

295 300 305cag cag ggc caa agc gga gct ttc acc gtc ctc gaa gtt gct cca tac 1075Gln Gln Gly Gln Ser Gly Ala Phe Thr Val Leu Glu Val Ala Pro Tyr310 315 320 325ctg ctc tcc cca gag aac ttg gac gat ctg atc gca cgc gac gtc 1120Leu Leu Ser Pro Glu Asn Leu Asp Asp Leu Ile Ala Arg Asp Val

330335340 taatttagct cgaggggcaa gga 1143<210>42<211>340<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>42Met His Leu Gly Lys Leu Asp Gln Asp Ser Ala Thr Thr Ile Leu Glu 151015 Asp Tyr Lys Asn Met Thr Asn Ile Arg Val Ala Ile Val Gly Tyr Gly

20 25 30Asn Leu Gly Arg Ser Val Glu Lys Leu Ile Ala Lys Gln Pro Asp Met

35 40 45Asp Leu Val Gly Ile Phe Ser Arg Arg Ala Thr Leu Asp Thr Lys Thr

50 55 60Pro Val Phe Asp Val Ala Asp Val Asp Lys His Ala Asp Asp Val Asp 65 70 75 80Val Leu Phe Leu Cys Met Gly Ser Ala Thr Asp Ile Pro Glu Gln Ala

85 90 95Pro Lys Phe Ala Gln Phe Ala Cys Thr Val Asp Thr Tyr Asp Asn His

100 105 110Arg Asp Ile Pro Arg His Arg Gln Val Met Asn Glu Ala Ala Thr Ala

115 120 125Ala Gly Asn Val Ala Leu Val Ser Thr Gly Trp Asp Pro Gly Met Phe

130 135 140Ser Ile Asn Arg Val Tyr Ala Ala Ala Val Leu Ala Glu His Gln Gln145 150 155 160His Thr Phe Trp Gly Pro Gly Leu Ser Gln Gly His Ser Asp Ala Leu

165 170 175Arg Arg Ile Pro Gly Val Gln Lys Ala Val Gln Tyr Thr Leu Pro Ser

180 185 190Glu Asp Ala Leu Glu Lys Ala Arg Arg Gly Glu Ala Gly Asp Leu Thr

195 200 205Gly Lys Gln Thr His Lys Arg Gln Cys Phe Val Val Ala Asp Ala Ala

210 215 220Asp His Glu Arg Ile Glu Asn Asp Ile Arg Thr Met Pro Asp Tyr Phe225 230 235 240Val Gly Tyr Glu Val Glu Val Asn Phe Ile Asp Glu Ala Thr Phe Asp

245 250 255Ser Glu His Thr Gly Met Pro His Gly Gly His Val Ile Thr Thr Gly

260 265 270Asp Thr Gly Gly Phe Asn His Thr Val Glu Tyr Ile Leu Lys Leu Asp

275 280 285Arg Asn Pro Asp Phe Thr Ala Ser Ser Gln Ile Ala Phe Gly Arg Ala

290 295 300Ala His Arg Met Lys Gln Gln Gly Gln Ser Gly Ala Phe Thr Val Leu305 310 315 320Glu Val Ala Pro Tyr Leu Leu Ser Pro Glu Asn Leu Asp Asp Leu Ile

325 330 335Ala Arg Asp Val

340<210>43<211>958<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (958)<223>FRXA00352<400>43aatagatcag cgcatccgtg gtggaaccaa aaggctcaac aatacgaaac gttcgctttc 60ggtcctgatg aaagagatgt ccctgaatca tcatctaagt atg cat ctc ggt aag 115

Met His Leu Gly Lys

1 5ctc gac cag gac agt gcc acc aca att ttg gag gat tac aag aac atg 163Leu Asp Gln Asp Ser Ala Thr Thr Ile Leu Glu Asp Tyr Lys Asn Met

10 15 20acc aac atc cgc gta gct atc gtg ggc tac gga aac ctg gga cgc agc 211Thr Asn Ile Arg Val Ala Ile Val Gly Tyr Gly Asn Leu Gly Arg Ser

25 30 35gtc gaa aag ctt att gcc aag cag ccc gac atg gac ctt gta gga atc 259Val Glu Lys Leu Ile Ala Lys Gln Pro Asp Met Asp Leu Val Gly Ile

40 45 50ttc tcg cgc cgg gcc acc ctc gac aca aag acg cca gtc ttt gat gtc 307Phe Ser Arg Arg Ala Thr Leu Asp Thr Lys Thr Pro Val Phe Asp Val

55 60 65gcc gac gtg gac aag cac gcc gac gac gtg gac gtg ctg ttc ctg tgc 355Ala Asp Val Asp Lys His Ala Asp Asp Val Asp Val Leu Phe Leu Cys 70 75 80 85atg ggc tcc gcc acc gac atc cct gag cag gca cca aag ttc gcg cag 403Met Gly Ser Ala Thr Asp Ile Pro Glu Gln Ala Pro Lys Phe Ala Gln

90 95 100ttc gcc tgc acc gta gac acc tac gac aac cac cgc gac atc cca cgc 451Phe Ala Cys Thr Val Asp Thr Tyr Asp Asn His Arg Asp Ile Pro Arg

105 110 115cac cgc cag gtc atg aac gaa gcc gcc acc gca gcc ggc aac gtt gca 499His Arg Gln Val Met Asn Glu Ala Ala Thr Ala Ala Gly Asn Val Ala

120 125 130ctg gtc tct acc ggc tgg gat cca gga atg ttc tcc atc aac cgc gtc 547Leu Val Ser Thr Gly Trp Asp Pro Gly Met Phe Ser Ile Asn Arg Val

135 140 145tac gca gcg gca gtc tta gcc gag cac cag cag cac acc ttc tgg ggc 595Tyr Ala Ala Ala Val Leu Ala Glu His Gln Gln His Thr Phe Trp Gly150 155 160 165cca ggt ttg tca cag ggc cac tcc gat gct ttg cga cgc atc cct ggc 643Pro Gly Leu Ser Gln Gly His Ser Asp Ala Leu Arg Arg Ile Pro Gly

170 175 180gtt caa aag gca gtc cag tac acc ctc cca tcc gaa gac gcc ctg gaa 691Val Gln Lys Ala Val Gln Tyr Thr Leu Pro Ser Glu Asp Ala Leu Glu

185 190 195aag gcc cgc cgc ggc gaa gcc ggc gac ctt acc gga aag caa acc cac 739Lys Ala Arg Arg Gly Glu Ala Gly Asp Leu Thr Gly Lys Gln Thr His

200 205 210aag cgc caa tgc ttc gtg gtt gcc gac gcg gcc gat cac gag cgc atc 787Lys Arg Gln Cys Phe Val Val Ala Asp Ala Ala Asp His Glu Arg Ile

215 220 225gaa aac gac atc cgc acc atg cct gat tac ttc gtt ggc tac gaa gtc 835Glu Asn Asp Ile Arg Thr Met Pro Asp Tyr Phe Val Gly Tyr Glu Val230 235 240 245gaa gtc aac ttc atc gac gaa gca acc ttc gac tcc gag cac acc ggc 883Glu Val Asn Phe Ile Asp Glu Ala Thr Phe Asp Ser Glu His Thr Gly

250 255 260atg cca cac ggt ggc cac gtg att acc acc ggc gac acc ggt ggc ttc 931Met Pro His Gly Gly His Val Ile Thr Thr Gly Asp Thr Gly Gly Phe

265 270 275aac cac acc gtg gaa tac atc ctc aag 958Asn His Thr Val Glu Tyr Ile Leu Lys

280285<210>44<211>286<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>44Met His Leu Gly Lys Leu Asp Gln Asp Ser Ala Thr Thr Ile Leu Glu 151015 Asp Tyr Lys Asn Met Thr Asn Ile Arg Val Ala Ile Val Gly Tyr Gly

20 25 30Asn Leu Gly Arg Ser Val Glu Lys Leu Ile Ala Lys Gln Pro Asp Met

35 40 45Asp Leu Val Gly Ile Phe Ser Arg Arg Ala Thr Leu Asp Thr Lys Thr

50 55 60Pro Val Phe Asp Val Ala Asp Val Asp Lys His Ala Asp Asp Val Asp 65 70 75 80Val Leu Phe Leu Cys Met Gly Ser Ala Thr Asp Ile Pro Glu Gln Ala

85 90 95Pro Lys Phe Ala Gln Phe Ala Cys Thr Val Asp Thr Tyr Asp Asn His

100 105 110Arg Asp Ile Pro Arg His Arg Gln Val Met Asn Glu Ala Ala Thr Ala

115 120 125Ala Gly Asn Val Ala Leu Val Ser Thr Gly Trp Asp Pro Gly Met Phe

130 135 140Ser Ile Asn Arg Val Tyr Ala Ala Ala Val Leu Ala Glu His Gln Gln145 150 155 160His Thr Phe Trp Gly Pro Gly Leu Ser Gln Gly His Ser Asp Ala Leu

165 170 175Arg Arg Ile Pro Gly Val Gln Lys Ala Val Gln Tyr Thr Leu Pro Ser

180 185 190Glu Asp Ala Leu Glu Lys Ala Arg Arg Gly Glu Ala Gly Asp Leu Thr

195 200 205Gly Lys Gln Thr His Lys Arg Gln Cys Phe Val Val Ala Asp Ala Ala

210 215 220Asp His Glu Arg Ile Glu Asn Asp Ile Arg Thr Met Pro Asp Tyr Phe225 230 235 240Val Gly Tyr Glu Val Glu Val Asn Phe Ile Asp Glu Ala Thr Phe Asp

245 250 255Ser Glu His Thr Gly Met Pro His Gly Gly His Val Ile Thr Thr Gly

260 265 270Asp Thr Gly Gly Phe Asn His Thr Val Glu Tyr Ile Leu Lys

275280285<210>45<21l>1400<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) } (1377)<223>RXA00972<400>45cct gca cct ggt tgg cgt ttc cgc acc gga gaa gat gta aca atg gct 48Pro Ala Pro Gly Trp Arg Phe Arg Thr Gly Glu Asp Val Thr Met Ala 151015 aca gtt gaa aat ttc aat gaa ctt ccc gca cac gta tgg cca cgc aat 96Thr Val Glu Asn Phe Asn Glu Leu Pro Ala His Val Trp Pro Arg Asn

20 25 30gcc gtg cgc caa gaa gac ggc gtt gtc acc gtc gct ggt gtg cct ctg 144Ala Val Arg Gln Glu Asp Gly Val Val Thr Val Ala Gly Val Pro Leu

35 40 45cct gac ctc gct gaa gaa tac gga acc cca ctg ttc gta gtc gac gag 192Pro Asp Leu Ala Glu Glu Tyr Gly Thr Pro Leu Phe Val Val Asp Glu

50 55 60gac gat ttc cgt tcc cgc tgt cgc gac atg gct acc gca ttc ggt gga 240Asp Asp Phe Arg Ser Arg Cys Arg Asp Met Ala Thr Ala Phe Gly Gly 65 70 75 80cca ggc aat gtg cac tac gca tct aaa gcg ttc ctg acc aag acc att 288Pro Gly Asn Val His Tyr Ala Ser Lys Ala Phe Leu Thr Lys Thr Ile

85 90 95gca cgt tgg gtt gat gaa gag ggg ctg gca ctg gac att gca tcc atc 336Ala Arg Trp Val Asp Glu Glu Gly Leu Ala Leu Asp Ile Ala Ser Ile

100 105 110aac gaa ctg ggc att gcc ctg gcc gct ggt ttc ccc gcc agc cgt gtc 384Asn Glu Leu Gly Ile Ala Leu Ala Ala Gly Phe Pro Ala Ser Arg Ile

115 120 125acc gcg cac ggc aac aac aaa ggc gta gag ttc ctg cgc gcg ttg gtt 432Thr Ala His Gly Asn Asn Lys Gly Val Glu Phe Leu Arg Ala Leu Val

130 135 140caa aac ggt gtg gga cac gtg gtg ctg gac tcc gca cag gaa cta gaa 480Gln Asn Gly Val Gly His Val Val Leu Asp Ser Ala Gln Glu Leu Glu145 150 155 160ctg ttg gat tac gtt gcc gct ggt gaa ggc aag att cag gac gtg ttg 528Leu Leu Asp Tyr Val Ala Ala Gly Glu Gly Lys Ile Gln Asp Val Leu

165 170 175atc cgc gta aag cca ggc atc gaa gca cac acc cac gag ttc atcgcc 576Ile Arg Val Lys Pro Gly Ile Glu Ala His Thr His Glu Phe Ile Ala

180 185 190act agc cac gaa gac cag aag ttc gga ttc tcc ctg gca tcc ggt tcc 624Thr Ser His Glu Asp Gln Lys Phe Gly Phe Ser Leu Ala Ser Gly Ser

195 200 205gca ttc gaa gca gca aaa gcc gcc aac aac gca gaa aac ctg aac ctg 672Ala Phe Glu Ala Ala Lys Ala Ala Asn Asn Ala Glu Asn Leu Asn Leu

210 215 220gtt ggc ctg cac tgc cac gtt ggt tcc cag gtg ttc gac gcc gaa ggc 720Val Gly Leu His Cys His Val Gly Ser Gln Val Phe Asp Ala Glu Gly225 230 235 240ttc aag ctg gca gca gaa cgc gtg ttg ggc ctg tac tca cag atc cac 768Phe Lys Leu Ala Ala Glu Arg Val Leu Gly Leu Tyr Ser Gln Ile His

245 250 255agc gaa ctg ggc gtt gcc ctt cct gaa ctg gat ctc ggt ggc gga tac 816Ser Glu Leu Gly Val Ala Leu Pro Glu Leu Asp Leu Gly Gly Gly Tyr

260 265 270ggc att gcc tat acc gca gct gaa gaa cca ctc aac gtc gca gaa gtt 864Gly Ile Ala Tyr Thr Ala Ala Glu Glu Pro Leu Asn Val Ala Glu Val

275 280 285gcc tcc gac ctg ctc acc gca gtc gga aaa atg gca gcg gaa cta ggc 912Ala Ser Asp Leu Leu Thr Ala Val Gly Lys Met Ala Ala Glu Leu Gly

290 295 300atc gac gca cca acc gtg ctt gtt gag ccc ggc cgc gct atc gca ggc 960Ile Asp Ala Pro Thr Val Leu Val Glu Pro Gly Arg Ala Ile Ala Gly305 310 315 320ccc tcc acc gtg acc atc tac gaa gtc ggc acc acc aaa gac gtc cac 1008Pro Ser Thr Val Thr Ile Tyr Glu Val Gly Thr Thr Lys Asp Val His

325 330 335gta gac gac gac aaa acc cgc cgt tac atc gcc gtg gac gga ggc atg 1056Val Asp Asp Asp Lys Thr Arg Arg Tyr Ile Ala Val Asp Gly Gly Met

340 345 350tcc gac aac atc cgc cca gca ctc tac ggg tcc gaa tac gac gcc cgc 1104Ser Asp Asn Ile Arg Pro Ala Leu Tyr Gly Ser Glu Tyr Asp Ala Arg

355 360 365gta gta tcc cgc ttc gcc gaa gga gac cca gta agc acc cgc atc gtg 1152Val Val Ser Arg Phe Ala Glu Gly Asp Pro Val Ser Thr Arg Ile Val

370 375 380ggc tcc cac tgc gaa tcc ggc gat atc ctg atc aac gat gaa atc tac 1200Gly Ser His Cys Glu Ser Gly Asp Ile Leu Ile Asn Asp Glu Ile Tyr385 390 395 400cca tct gac atc acc agc ggc gac ttc ctt gca ctc gca gcc acc ggc 1248Pro Ser Asp Ile Thr Ser Gly Asp Phe Leu Ala Leu Ala Ala Thr Gly

405 410 415gca tac tgc tac gcc atg agc tcc cgc tac aac gcc ttc aca cgg ccc 1296Ala Tyr Cys Tyr Ala Met Ser Ser Arg Tyr Asn Ala Phe Thr Arg Pro

420 425 430gcc gtc gtg tcc gtc cgc gct ggc agc tcc cgc ctc atg ctg cgc cgc 1344Ala Val Val Ser Val Arg Ala Gly Ser Ser Arg Leu Met Leu Arg Arg

435 440 445gaa acg ctc gac gac atc ctc tca cta gag gca taacgctttt cgacgcctga 1397Glu Thr Leu Asp Asp Ile Leu Ser Leu Glu Ala

450455 ccc 1400<210>46<211>459<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>46Pro Ala Pro Gly Trp Arg Phe Arg Thr Gly Glu Asp Val Thr Met Ala 151015 Thr Val Glu Asn Phe Asn Glu Leu Pro Ala His Val Trp Pro Arg Asn

2025 30Ala Val Arg Gln Glu Asp Gly Val Val Thr Val Ala Gly Val Pro Leu

35 40 45Pro Asp Leu Ala Glu Glu Tyr Gly Thr Pro Leu Phe Val Val Asp Glu

50 55 60Asp Asp Phe Arg Ser Arg Cys Arg Asp Met Ala Thr Ala Phe Gly Gly 65 70 75 80Pro Gly Asn Val His Tyr Ala Ser Lys Ala Phe Leu Thr Lys Thr Ile

85 90 95Ala Arg Trp Val Asp Glu Glu Gly Leu Ala Leu Asp Ile Ala Ser Ile

100 105 110Asn Glu Leu Gly Ile Ala Leu Ala Ala Gly Phe Pro Ala Ser Arg Ile

115 120 125Thr Ala His Gly Asn Asn Lys Gly Val Glu Phe Leu Arg Ala Leu Val

130 135 140Gln Asn Gly Val Gly His Val Val Leu Asp Ser Ala Gln Glu Leu Glu145 150 155 160Leu Leu Asp Tyr Val Ala Ala Gly Glu Gly Lys Ile Gln Asp Val Leu

165 170 175Ile Arg Val Lys Pro Gly Ile Glu Ala His Thr His Glu Phe Ile Ala

180 185 190Thr Ser His Glu Asp Gln Lys Phe Gly Phe Ser Leu Ala Ser Gly Ser

195 200 205Ala Phe Glu Ala Ala Lys Ala Ala Asn Asn Ala Glu Asn Leu Asn Leu

210 215 220Val Gly Leu His Cys His Val Gly Ser Gln Val Phe Asp Ala Glu Gly225 230 235 240Phe Lys Leu Ala Ala Glu Arg Val Leu Gly Leu Tyr Ser Gln Ile His

245 250255Ser Glu Leu Gly Val Ala Leu Pro Glu Leu Asp Leu Gly Gly Gly Tyr

260 265 270Gly Ile Ala Tyr Thr Ala Ala Glu Glu Pro Leu Asn Val Ala Glu Val

275 280 285Ala Ser Asp Leu Leu Thr Ala Val Gly Lys Met Ala Ala Glu Leu Gly

290 295 300Ile Asp Ala Pro Thr Val Leu Val Glu Pro Gly Arg Ala Ile Ala Gly305 310 315 320Pro Ser Thr Val Thr Ile Tyr Glu Val Gly Thr Thr Lys Asp Val His

325 330 335Val Asp Asp Asp Lys Thr Arg Arg Tyr Ile Ala Val Asp Gly Gly Met

340 345 350Ser Asp Asn Ile Arg Pro Ala Leu Tyr Gly Ser Glu Tyr Asp Ala Arg

355 360 365Val Val Ser Arg Phe Ala Glu Gly Asp Pro Val Ser Thr Arg Ile Val

370 375 380Gly Ser His Cys Glu Ser Gly Asp Ile Leu Ile Asn Asp Glu Ile Tyr385 390 395 400Pro Ser Asp Ile Thr Ser Gly Asp Phe Leu Ala Leu Ala Ala Thr Gly

405 410 415Ala Tyr Cys Tyr Ala Met Ser Ser Arg Tyr Asn Ala Phe Thr Arg Pro

420 425 430Ala Val Val Ser Val Arg Ala Gly Ser Ser Arg Leu Met Leu Arg Arg

435 440 445Glu Thr Leu Asp Asp Ile Leu Ser Leu Glu Ala

450455<210>47<211>2121<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (2098)<223>RXA02653<400>47agacagagtg ttagtgcgtg gggcagctct cactttcatc gacatcactc gagtatgctc 60accggccgta ttcattccaa taacccgcac agggaaacta atg ata ccg aag ccc 115

Met Ile Pro Lys Pro

1 5gac gtg acc gac tta tat tta gag gac ctc tta aat gag ggt tcg gaa 163Asp Val Thr Asp Leu Tyr Leu Glu Asp Leu Leu Asn Glu Gly Ser Glu

10 15 20aag att cgg tcc gcc aag gat ctt tcc gaa ctt agg aca gtt cta aaa 211Lys Ile Arg Ser Ala Lys Asp Leu Ser Glu Leu Arg Thr Val Leu Lys

25 30 35gag gtt tcc tcc caa att cag gaa cga gct ggg aaa aaa gat gaa gaa 259Glu Val Ser Ser Gln Ile Gln Glu Arg Ala Gly Lys Lys Asp Glu Glu

40 45 50tgg gga atg ggg gcc act tgg cgg gag ctg tac ccc agc atc gtg gaa 307Trp Gly Met Gly Ala Thr Trp Arg Glu Leu Tyr Pro Ser Ile Val Glu

55 60 65cgc gct tcc tac gaa ggg cgt gac agc cta atc gga ttt gat cac tta 355Arg Ala Ser Tyr Glu Gly Arg Asp Ser Leu Ile Gly Phe Asp His Leu 70 75 80 85gcc cgg gaa atg gaa aga tta gcc ttc ggc cca cca tcc gaa agt ttt 403Ala Arg Glu Met Glu Arg Leu Ala Phe Gly Pro Pro Ser Glu Ser Phe

90 95 100gaa tac ctc caa gaa ctc gta aaa tcc gga gtg gta gac atc act cac 451Glu Tyr Leu Gln Glu Leu Val Lys Ser Gly Val Val Asp Ile Thr His

105 110 115ctg cat cgt ggc cgg gaa cca ctg aca gat tta gtt cgt gaa ctt gaa 499Leu His Arg Gly Arg Glu Pro Leu Thr Asp Leu Val Arg Glu Leu Glu

120 125 130ata act gtg gtg ata gac gct gtt ctt ccc ccg ccg gga gta gtg cca 547Ile Thr Val Val Ile Asp Ala Val Leu Pro Pro Pro Gly Val Val Pro

135 140 145ggc aca ttg gtg cac aat ttg gta aaa gag gga tat gcc aga atg cgt 595Gly Thr Leu Val His Asn Leu Val Lys Glu Gly Tyr Ala Arg Met Arg150 155 160 165cct ggg act cgg ggg tta gat gta gcg gct gac ggc acc gtt caa ggg 643Pro Gly Thr Arg Gly Leu Asp Val Ala Ala Asp Gly Thr Val Gln Gly

170 175 180caa cga cat ttg gct gca gtc gga cgg atg acg gaa gat gtg gtt ttg 691Gln Arg His Leu Ala Ala Val Gly Arg Met Thr Glu Asp Val Val Leu

185 190 195ggt aat gac aca ttg tcg cga tca tta cat gac ata atc ccg aag tgg 739Gly Asn Asp Thr Leu Ser Arg Ser Leu His Asp Ile Ile Pro Lys Trp

200 205 210gct cgt cga gtt atc cgc gac gcg agc acg tat ccc gat agg gta cat 787Ala Arg Arg Val Ile Arg Asp Ala Ser Thr Tyr Pro Asp Arg Val His

215 220 225ggt act cca ccg ctt ccg gca cgg ttg gaa ccc tgg gcg gaa aag ctc 835Gly Thr Pro Pro Leu Pro Ala Arg Leu Glu Pro Trp Ala Glu Lys Leu230 235 240 245act tca gat ccg gcc aca tgc cgc cac ctg att gaa gaa ttc ggg agt 883Thr Ser Asp Pro Ala Thr Cys Arg His Leu Ile Glu Glu Phe Gly Ser

250 255 260cct gtg aat gta ctc cat tca ggt tct atg cct cgt aat ata aat gag 931Pro Val Asn Val Leu His Ser Gly Ser Met Pro Arg Asn Ile Asn Glu

265 270 275ttg gtt gac gcc ggc att cag atg ggg gtg gat act cga ata ttt ttt 979Leu Val Asp Ala Gly Ile Gln Met Gly Val Asp Thr Arg Ile Phe Phe

280 285 290gcc cgc aaa gcg aat aag ggt ctt acc ttc gtt gat gcc gtt aaa gac 1027Ala Arg Lys Ala Asn Lys Gly Leu Thr Phe Val Asp Ala Val Lys Asp

295 300 305acc ggt cat ggt gta gat gta gcc agt gaa cga gag tta tct cag gtg 1075Thr Gly His Gly Val Asp Val Ala Ser Glu Arg Glu Leu Ser Gln Val310 315 320 325ctt aat cgt gga gtc cca gga gag cgg atc att cta tcc gca gct atc 1123Leu Asn Arg Gly Val Pro Gly Glu Arg Ile Ile Leu Ser Ala Ala Ile

330 335 340aaa ccg gac aga cta ttg gca tta gcg atc gaa aat ggc gtg atc atc 1171Lys Pro Asp Arg Leu Leu Ala Leu Ala Ile Glu Asn Gly Val Ile Ile

345 350 355tct gtg gat tcg cgt gat gaa tta gat cgc att tcg gct ttg gtt ggt 1219Ser Val Asp Ser Arg Asp Glu Leu Asp Arg Ile Ser Ala Leu Val Gly

360 365 370gac cgc gtt gca cga gtt gcg cct aga gta gct cca gat cct gca gtc 1267Asp Arg Val Ala Arg Val Ala Pro Arg Val Ala Pro Asp Pro Ala Val

375 380 385tta cct cca act aga ttt ggt gag cgt gct gca gac tgg ggt aat cgg 1315Leu Pro Pro Thr Arg Phe Gly Glu Arg Ala Ala Asp Trp Gly Asn Arg390 395 400 405ctt acc gag gtg ata ccc ggc gtg gat att gtg ggt ctt cac gtt cac 1363Leu Thr Glu Val Ile Pro Gly Val Asp Ile Val Gly Leu His Val His

410 415 420ctc cat ggc tat gct gca aaa gac cgt gct ctg gct ctg cag gaa tgt 1411Leu His Gly Tyr Ala Ala Lys Asp Arg Ala Leu Ala Leu Gln Glu Cys

425 430435tgc caa ctc gtc gat tct ctc aga gaa tgc ggg cat tcc cca cag ttt 1459Cys Gln Leu Val Asp Ser Leu Arg Glu Cys Gly His Ser Pro Gln Phe

440 445 450att gac ctt gga gga ggg gtg cct atg agc tac att gaa tct gag gaa 1507Ile Asp Leu Gly Gly Gly Val Pro Met Ser Tyr Ile Glu Ser Glu Glu

455 460 465gat tgg atc cgt tat caa tcc gct aaa tct gcg act tca gcc ggg tat 1555Asp Trp Ile Arg Tyr Gln Ser Ala Lys Ser Ala Thr Ser Ala Gly Tyr470 475 480 485gcc gaa tcc ttt acg tgg aaa gac gat ccg tta tct aat acg tac ccg 1603Ala Glu Ser Phe Thr Trp Lys Asp Asp Pro Leu Ser Asn Thr Tyr Pro

490 495 500ttc tat cag acc cca gtg cgc ggt aat tgg ttg aaa gac gtg ctt tct 1651Phe Tyr Gln Thr Pro Val Arg Gly Asn Trp Leu Lys Asp Val Leu Ser

505 510 515aag ggg gta gct cag atg ctc att gac cgg gga ttg cgg tta cac ata 1699Lys Gly Val Ala Gln Met Leu Ile Asp Arg Gly Leu Arg Leu His Ile

520 525 530gag cct ggt cga agt tta cta gat ggg tgt ggc gtc act ctt gcc gaa 1747Glu Pro Gly Arg Ser Leu Leu Asp Gly Cys Gly Val Thr Leu Ala Glu

535 540 545gtt gct ttt gtg aaa acc cga agt gac ggg ttg cct cta gtg gga ctg 1795Val Ala Phe Val Lys Thr Arg Ser Asp Gly Leu Pro Leu Val Gly Leu550 555 560 565gct atg aac cga acg cag tgc cgg act aca tcc gat gat ttt ctc att 1843Ala Met Asn Arg Thr Gln Cys Arg Thr Thr Ser Asp Asp Phe Leu Ile

570 575 580gat ccc ctg cat atc act gac ggt gat gta ggc gag gaa atc gaa gca 1891Asp Pro Leu His Ile Thr Asp Gly Asp Val Gly Glu Glu Ile Glu Ala

585 590 595tat cta gtg ggt gcc tac tgc atc gaa gat gag ctg att tta cgc cgg 1939Tyr Leu Val Gly Ala Tyr Cys Ile Glu Asp Glu Leu Ile Leu Arg Arg

600 605 610cga atc cgc ttc ccg aga gga gtc aaa cca gga gat atc atc gga att 1987Arg Ile Arg Phe Pro Arg Gly Val Lys Pro Gly Asp Ile Ile Gly Ile

615 620 625cct aac acc gca gga tac ttc atg cat atc ttg gaa agt gca tcg cac 2035Pro Asn Thr Ala Gly Tyr Phe Met His Ile Leu Glu Ser Ala Ser His630 635 640 645caa atc ccg ttg gcg aaa aat gta gtg tgg ccg gag ggg cag tta gac 2083Gln Ile Pro Leu Ala Lys Asn Val Val Trp Pro Glu Gly Gln Leu Asp

650 655 660gat atc gat gcg gat taagacataa ccattcgcta atc 2121Asp Ile Asp Ala Asp

665<210>48<211>666<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>48Met Ile Pro Lys Pro Asp Val Thr Asp Leu Tyr Leu Glu Asp Leu Leu 151015 Asn Glu Gly Ser Glu Lys Ile Arg Ser Ala Lys Asp Leu Ser Glu Leu

20 25 30Arg Thr Val Leu Lys Glu Val Ser Ser Gln Ile Gln Glu Arg Ala Gly

35 40 45Lys Lys Asp Glu Glu Trp Gly Met Gly Ala Thr Trp Arg Glu Leu Tyr

50 55 60Pro Ser Ile Val Glu Arg Ala Ser Tyr Glu Gly Arg Asp Ser Leu Ile 65 70 75 80Gly Phe Asp His Leu Ala Arg Glu Met Glu Arg Leu Ala Phe Gly Pro

85 90 95Pro Ser Glu Ser Phe Glu Tyr Leu Gln Glu Leu Val Lys Ser Gly Val

100 105 110Val Asp Ile Thr His Leu His Arg Gly Arg Glu Pro Leu Thr Asp Leu

115 120 125Val Arg Glu Leu Glu Ile Thr Val Val Ile Asp Ala Val Leu Pro Pro

130 135 140Pro Gly Val Val Pro Gly Thr Leu Val His Asn Leu Val Lys Glu Gly145 150 155 160Tyr Ala Arg Met Arg Pro Gly Thr Arg Gly Leu Asp Val Ala Ala Asp

165 170 175Gly Thr Val Gln Gly Gln Arg His Leu Ala Ala Val Gly Arg Met Thr

180 185 190Glu Asp Val Val Leu Gly Asn Asp Thr Leu Ser Arg Ser Leu His Asp

195 200 205Ile Ile Pro Lys Trp Ala Arg Arg Val Ile Arg Asp Ala Ser Thr Tyr

210 215 220Pro Asp Arg Val His Gly Thr Pro Pro Leu Pro Ala Arg Leu Glu Pro225 230 235 240Trp Ala Glu Lys Leu Thr Ser Asp Pro Ala Thr Cys Arg His Leu Ile

245 250 255Glu Glu Phe Gly Ser Pro Val Asn Val Leu His Ser Gly Ser Met Pro

260 265 270Arg Asn Ile Asn Glu Leu Val Asp Ala Gly Ile Gln Met Gly Val Asp

275 280 285Thr Arg Ile Phe Phe Ala Arg Lys Ala Asn Lys Gly Leu Thr Phe Val

290 295 300Asp Ala Val Lys Asp Thr Gly His Gly Val Asp Val Ala Ser Glu Arg305 310 315 320Glu Leu Ser GlnVal Leu Asn Arg Gly Val Pro Gly Glu Arg Ile Ile

325 330 335Leu Ser Ala Ala Ile Lys Pro Asp Arg Leu Leu Ala Leu Ala Ile Glu

340 345 350Asn Gly Val Ile Ile Ser Val Asp Ser Arg Asp Glu Leu Asp Arg Ile

355 360 365Ser Ala Leu Val Gly Asp Arg Val Ala Arg Val Ala Pro Arg Val Ala

370 375 380Pro Asp Pro Ala Val Leu Pro Pro Thr Arg Phe Gly Glu Arg Ala Ala385 390 395 400Asp Trp Gly Asn Arg Leu Thr Glu Val Ile Pro Gly Val Asp Ile Val

405 410 415Gly Leu His Val His Leu His Gly Tyr Ala Ala Lys Asp Arg Ala Leu

420 425 430Ala Leu Gln Glu Cys Cys Gln Leu Val Asp Ser Leu Arg Glu Cys Gly

435 440 445His Ser Pro Gln Phe Ile Asp Leu Gly Gly Gly Val Pro Met Ser Tyr

450 455 460Ile Glu Ser Glu Glu Asp Trp Ile Arg Tyr Gln Ser Ala Lys Ser Ala465 470 475 480Thr Ser Ala Gly Tyr Ala Glu Ser Phe Thr Trp Lys Asp Asp Pro Leu

485 490 495Ser Asn Thr Tyr Pro Phe Tyr Gln Thr Pro Val Arg Gly Asn Trp Leu

500 505 510Lys Asp Val Leu Ser Lys Gly Val Ala Gln Met Leu Ile Asp Arg Gly

515 520 525Leu Arg Leu His Ile Glu Pro Gly Arg Ser Leu Leu Asp Gly Cys Gly

530 535 540Val Thr LeuAla Glu Val Ala Phe Val Lys Thr Arg Ser Asp Gly Leu545 550 555 560Pro Leu Val Gly Leu Ala Met Asn Arg Thr Gln Cys Arg Thr Thr Ser

565 570 575Asp Asp Phe Leu Ile Asp Pro Leu His Ile Thr Asp Gly Asp Val Gly

580 585 590Glu Glu Ile Glu Ala Tyr Leu Val Gly Ala Tyr Cys Ile Glu Asp Glu

595 600 605Leu Ile Leu Arg Arg Arg Ile Arg Phe Pro Arg Gly Val Lys Pro Gly

610 615 620Asp Ile Ile Gly Ile Pro Asn Thr Ala Gly Tyr Phe Met His Ile Leu625 630 635 640Glu Ser Ala Ser His Gln Ile Pro Leu Ala Lys Asn Val Val Trp Pro

645 650 655Glu Gly Gln Leu Asp Asp Ile Asp Ala Asp

660665<210>49<211>993<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (970)<223>RXA01393<400>49caaaagcaga cctgtaatga agatttccat gatcaccatc gtgacctatg gaagtactta 60agtaaaatga ttggttctta acatggttta atatagcttc atg aac ccc att caa 115

Met Asn Pro Ile Gln

1 5 ctg gac act ttg ctc tca atc att gat gaa ggc agc ttc gaa ggc gcc 163Leu Asp Thr Leu Leu Ser Ile Ile Asp Glu Gly Ser Phe Glu Gly Ala

l0 15 20tcc tta gcc ctt tcc att tcc ccc tcg gcg gtg agt cag cgc gtt aaa 211Ser Leu Ala Leu Ser Ile Ser Pro Ser Ala Val Ser Gln Arg Val Lys

25 3035gct ctc gag cat cac gtg ggt cga gtg ttg gta tcg cgc acc caa ccg 259Ala Leu Glu His His Val Gly Arg Val Leu Val Ser Arg Thr Gln Pro

40 45 50gcc aaa gca acc gaa gcg ggt gaa gtc ctt gtg caa gca gcg cgg aaa 307Ala Lys Ala Thr Glu Ala Gly Glu Val Leu Val Gln Ala Ala Arg Lys

55 60 65atg gtg ttg ctg caa gca gaa act aaa gcg caa cta tct gga cgc ctt 355Met Val Leu Leu Gln Ala Glu Thr Lys Ala Gln Leu Ser Gly Arg Leu 70 75 80 85gct gaa atc ccg tta acc atc gcc atc aac gca gat tcg cta tcc aca 403Ala Glu Ile Pro Leu Thr Ile Ala Ile Asn Ala Asp Ser Leu Ser Thr

90 95 100tgg ttt cct ccc gtg ttc aac gag gta gct tct tgg ggt gga gca acg 451Trp Phe Pro Pro Val Phe Asn Glu Val Ala Ser Trp Gly Gly Ala Thr

105 110 115ctc acg ctg cgc ttg gaa gat gaa gcg cac aca tta tcc ttg ctg cgg 499Leu Thr Leu Arg Leu Glu Asp Glu Ala His Thr Leu Ser Leu Leu Arg

120 125 130cgt gga gat gtt tta gga gcg gta acc cgt gaa gct aat ccc gtg gcg 547Arg Gly Asp Val Leu Gly Ala Val Thr Arg Glu Ala Asn Pro Val Ala

135 140 145gga tgt gaa gta gta gaa ctt gga acc atg cgc cac ttg gcc att gca 595Gly Cys Glu Val Val Glu Leu Gly Thr Met Arg His Leu Ala Ile Ala150 155 160 165acc ccc tca ttg cgg gat gcc tac atg gtt gat ggg aaa cta gat tgg 643Thr Pro Ser Leu Arg Asp Ala Tyr Met Val Asp Gly Lys Leu Asp Trp

170 175 180gct gcg atg ccc gtc tta cgc ttc ggt ccc aaa gat gtg ctt caa gac 691Ala Ala Met Pro Val Leu Arg Phe Gly Pro Lys Asp Val Leu Gln Asp

185 190 195cgt gac ctg gac ggg cgc gtc gat ggt cct gtg ggg cgc agg cgc gta 739Arg Asp Leu Asp Gly Arg Val Asp Gly Pro Val Gly Arg Arg Arg Val

200 205 210tcc att gtc ccg tcg gcg gaa ggt ttt ggt gag gca att cgc cga ggc 787Ser Ile Val Pro Ser Ala Glu Gly Phe Gly Glu Ala Ile Arg Arg Gly

215 220 225ctt ggt tgg gga ctt ctt ccc gaa acc caa gct gct ccc atg cta aaa 835Leu Gly Trp Gly Leu Leu Pro Glu Thr Gln Ala Ala Pro Met Leu Lys230 235 240 245gca gga gaa gtg atc ctc ctc gat gag ata ccc att gac aca ccg atg 883Ala Gly Glu Val Ile Leu Leu Asp Glu Ile Pro Ile Asp Thr Pro Met

250 255 260tat tgg caa cga tgg cgc ctg gaa tct aga tct cta gct aga ctc aca 931Tyr Trp Gln Arg Trp Arg Leu Glu Ser Arg Ser Leu Ala Arg Leu Thr

265 270 275gac gcc gtc gtt gat gca gca atc gag gga ttg cgg cct tagttacttc 980Asp Ala Val Val Asp Ala Ala Ile Glu Gly Leu Arg Pro

280285290 tgaaaaggtt cag 993<210>50<211>290<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>50Met Asn Pro Ile Gln Leu Asp Thr Leu Leu Ser Ile Ile Asp Glu Gly 151015 Ser Phe Glu Gly Ala Ser Leu Ala Leu Ser Ile Ser Pro Ser Ala Val

20 25 30Ser Gln Arg Val Lys Ala Leu Glu His His Val Gly Arg Val Leu Val

35 40 45Ser Arg Thr Gln Pro Ala Lys Ala Thr Glu Ala Gly Glu Val Leu Val

50 55 60Gln Ala Ala Arg Lys Met Val Leu Leu Gln Ala Glu Thr Lys Ala Gln 65 70 75 80Leu Ser Gly Arg Leu Ala Glu Ile Pro Leu Thr Ile Ala Ile Asn Ala

85 90 95Asp Ser Leu Ser Thr Trp Phe Pro Pro Val Phe Asn Glu Val Ala Ser

100 105 110Trp Gly Gly Ala Thr Leu Thr Leu Arg Leu Glu Asp Glu Ala His Thr

115 120 125Leu Ser Leu Leu Arg Arg Gly Asp Val Leu Gly Ala Val Thr Arg Glu

130 135 140Ala Asn Pro Val Ala Gly Cys Glu Val Val Glu Leu Gly Thr Met Arg145 150 155 160His Leu Ala Ile Ala Thr Pro Ser Leu Arg Asp Ala Tyr Met Val Asp

165 170 175Gly Lys Leu Asp Trp Ala Ala Met Pro Val Leu Arg Phe Gly Pro Lys

180 185 190Asp Val Leu Gln Asp Arg Asp Leu Asp Gly Arg Val Asp Gly Pro Val

195 200 205Gly Arg Arg Arg Val Ser Ile Val Pro Ser Ala Glu Gly Phe Gly Glu

210 215 220Ala Ile Arg Arg Gly Leu Gly Trp Gly Leu Leu Pro Glu Thr Gln Ala225 230 235 240Ala Pro Met Leu Lys Ala Gly Glu Val Ile Leu Leu Asp Glu Ile Pro

245 250 255Ile Asp Thr Pro Met Tyr Trp Gln Arg Trp Arg Leu Glu Ser Arg Ser

260 265 270Leu Ala Arg Leu Thr Asp Ala Val Val Asp Ala Ala Ile Glu Gly Leu

275 280 285Arg Pro

290<210>51<211>1626<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1603)<223>RXA00241<400>51ggtctccagc ctttctaaac aattcatctg cacttgatta attggcccca agattacgcg 60aagtttagcg acttcgccgt acgtcaacta cgttaaatga gtg aat act caa tca 115

Val Asn Thr Gln Ser

1 5gat tct gcg ggg tct caa ggt gca gcg gcc aca agt cgt act gta tct 163Asp Ser Ala Gly Ser Gln Gly Ala Ala Ala Thr Ser Arg Thr Val Ser

10 15 20att aga acc ctc atc gcg ctg atc atc gga tcg acc gtc ggc gcg gga 211Ile Arg Thr Leu Ile Ala Leu Ile Ile Gly Ser Thr Val Gly Ala Gly

25 30 35att ttc tcc atc cct caa aac atc ggc tca gtc gca ggt ccc ggc gcg 259Ile Phe Ser Ile Pro Gln Asn Ile Gly Ser Val Ala Gly Pro Gly Ala

40 45 50atg ctc atc ggc tgg ctg atc gcc ggt gtg ggc atg ttg tcc gta gcg 307Met Leu Ile Gly Trp Leu Ile Ala Gly Val Gly Met Leu Ser Val Ala

55 60 65ttc gtg ttc cat gtt ctt gcc cgc cgt aaa cct cac ctc gat tct ggc 355Phe Val Phe His Val Leu Ala Arg Arg Lys Pro His Leu Asp Ser Gly 70 75 80 85gtc tac gca tat gcg cgt gtt gga ttg ggc gat tat gta ggt ttc tcc 403Val Tyr Ala Tyr Ala Arg Val Gly Leu Gly Asp Tyr Val Gly Phe Ser

90 95 100tcc gct tgg ggt tat tgg ctg ggt tca gtc atc gcc caa gtt ggc tac 451Ser Ala Trp Gly Tyr Trp Leu Gly Ser Val Ile Ala Gln Val Gly Tyr

105 110115gca acg tta ttt ttc tcc acg ttg ggc cac tac gta ccg ctg ttt tcc 499Ala Thr Leu Phe Phe Ser Thr Leu Gly His Tyr Val Pro Leu Phe Ser

120 125 130caa gat cat cca ttt gtg tca gcg ttg gca gtt agc gct ttg acc tgg 547Gln Asp His Pro Phe Val Ser Ala Leu Ala Val Ser Ala Leu Thr Trp

135 140 145ctg gtg ttt gga gtt gtt tcc cga gga att agc caa gct gct ttc ttg 595Leu Val Phe Gly Val Val Ser Arg Gly Ile Ser Gln Ala Ala Phe Leu150 155 160 165aca acg gtc acc acc gtg gcc aaa att ctg cct ctg ttg tgc ttc atc 643Thr Thr Val Thr Thr Val Ala Lys Ile Leu Pro Leu Leu Cys Phe Ile

170 175 180atc ctt gtt gca ttc ttg ggc ttt agc tgg gag aag ttc act gtt gat 691Ile Leu Val Ala Phe Leu Gly Phe Ser Trp Glu Lys Phe Thr Val Asp

185 190 195tta tgg gcg cgt gat ggt ggc gtg ggc agc att ttt gat cag gtg cgc 739Leu Trp Ala Arg Asp Gly Gly Val Gly Ser Ile Phe Asp Gln Val Arg

200 205 210ggc atc atg gtg tac acc gtg tgg gtg ttc atc ggt atc gaa ggt gca 787Gly Ile Met Val Tyr Thr Val Trp Val Phe Ile Gly Ile Glu Gly Ala

215 220 225tcg gta tat tcc cgc cag gca cgc tca cgc agt gat gtc agc cga gct 835Ser Val Tyr Ser Arg Gln Ala Arg Ser Arg Ser Asp Val Ser Arg Ala230 235 240 245acc gtg att ggt ttt gtg gct gtt ctc ctt ttg ctg gtg tcg att tct 883Thr Val Ile Gly Phe Val Ala Val Leu Leu Leu Leu Val Ser Ile Ser

250 255 260tcg ctg agc ttc ggt gta ctg acc caa caa gag ctc gct gcg tta cca 931Ser Leu Ser Phe Gly Val Leu ThrGln Gln Glu Leu Ala Ala Leu Pro

265 270 275gat aat tcc atg gcg tcg gtg ctc gaa gct gtt gtt ggt cca tgg ggt 979Asp Asn Ser Met Ala Ser Val Leu Glu Ala Val Val Gly Pro Trp Gly

280 285 290gcc gca ttg att tcg ttg ggt ctg tgt ctt tcg gtt ctt ggg gcc tat 1027Ala Ala Leu Ile Ser Leu Gly Leu Cys Leu Ser Val Leu Gly Ala Tyr

295 300 305gtg tcc tgg cag atg ctc tgc gca gaa cca ctg gcg ttg atg gca atg 1075Val Ser Trp Gln Met Leu Cys Ala Glu Pro Leu Ala Leu Met Ala Met310 315 320 325gat ggc ctc att cca agc aaa atc ggg gcc atc aac agc cgc ggt gct 1123Asp Gly Leu Ile Pro Ser Lys Ile Gly Ala Ile Asn Ser Arg Gly Ala

330 335 340gcc tgg atg gct cag ctg atc tcc acc atc gtg att cag att ttc atc 1171Ala Trp Met Ala Gln Leu Ile Ser Thr Ile Val Ile Gln Ile Phe Ile

345 350 355atc att ttc ttc ctc aac gag acc acc tac gtc tcc atg gtg caa ttg 1219Ile Ile Phe Phe Leu Asn Glu Thr Thr Tyr Val Ser Met Val Gln Leu

360 365 370gct acc aac cta tac ttg gtg cct tac ctg ttc tct gcc ttt tat ctg 1267Ala Thr Asn Leu Tyr Leu Val Pro Tyr Leu Phe Ser Ala Phe Tyr Leu

375 380 385gtc atg ctg gca aca cgt gga aaa gga atc acc cac cca cat gcc ggc 1315Val Met Leu Ala Thr Arg Gly Lys Gly Ile Thr His Pro His Ala Gly390 395 400 405aca cgt ttt gat gat tcc ggt cca gag ata tcc cgc cga gaa aac cgc 1363Thr Arg Phe Asp Asp Ser Gly Pro Glu Ile Ser Arg Arg Glu Asn Arg

410 415420aaa cac ctc atc gtc ggt tta gta gca acg gtg tat tca gtg tgg ctg 1411Lys His Leu Ile Val Gly Leu Val Ala Thr Val Tyr Ser Val Trp Leu

425 430 435ttt tac gct gca gaa ccg cag ttt gtc ctc ttc gga gcc atg gcg atg 1459Phe Tyr Ala Ala Glu Pro Gln Phe Val Leu Phe Gly Ala Met Ala Met

440 445 450ctt ccc ggc tta atc ccc tat gtg tgg aca agg att tat cgt ggc gaa 1507Leu Pro Gly Leu Ile Pro Tyr Val Trp Thr Arg Ile Tyr Arg Gly Glu

455 460 465cag gtg ttt aac cgc ttt gaa atc ggc gtg gtt gtt gtc ctg gtc gtt 1555Gln Val Phe Asn Arg Phe Glu Ile Gly Val Val Val Val Leu Val Val470 475 480 485gct gcc agc gcg ggc gtt att ggt ttg gtc aac gga tca cta tcg ctt 1603Ala Ala Ser Ala Gly Val Ile Gly Leu Val Asn Gly Ser Leu Ser Leu

490495500 taaacaccga aaccttcctg cta 1626<210>52<211>501<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>52Val Asn Thr Gln Ser Asp Ser Ala Gly Ser Gln Gly Ala Ala Ala Thr 151015 Ser Arg Thr Val Ser Ile Arg Thr Leu Ile Ala Leu Ile Ile Gly Ser

20 25 30Thr Val Gly Ala Gly Ile Phe Ser Ile Pro Gln Asn Ile Gly Ser Val

35 40 45Ala Gly Pro Gly Ala Met Leu Ile Gly Trp Leu Ile Ala Gly Val Gly

50 55 60Met Leu Ser Val Ala Phe Val Phe His Val Leu Ala Arg Arg Lys Pro 65 70 75 80His Leu Asp Ser Gly Val Tyr Ala Tyr Ala Arg Val Gly Leu Gly Asp

85 90 95Tyr Val Gly Phe Ser Ser Ala Trp Gly Tyr TrpLeu Gly Ser Val Ile

100 105 110Ala Gln Val Gly Tyr Ala Thr Leu Phe Phe Ser Thr Leu Gly His Tyr

115 120 125Val Pro Leu Phe Ser Gln Asp His Pro Phe Val Ser Ala Leu Ala Val

130 135 140Ser Ala Leu Thr Trp Leu Val Phe Gly Val Val Ser Arg Gly Ile Ser145 150 155 160Gln Ala Ala Phe Leu Thr Thr Val Thr Thr Val Ala Lys Ile Leu Pro

165 170 175Leu Leu Cys Phe Ile Ile Leu Val Ala Phe Leu Gly Phe Ser Trp Glu

180 185 190Lys Phe Thr Val Asp Leu Trp Ala Arg Asp Gly Gly Val Gly Ser Ile

195 200 205Phe Asp Gln Val Arg Gly Ile Met Val Tyr Thr Val Trp Val Phe Ile

210 215 220Gly Ile Glu Gly Ala Ser Val Tyr Ser Arg Gln Ala Arg Ser Arg Ser225 230 235 240Asp Val Ser Arg Ala Thr Val Ile Gly Phe Val Ala Val Leu Leu Leu

245 250 255Leu Val Ser Ile Ser Ser Leu Ser Phe Gly Val Leu Thr Gln Gln Glu

260 265 270Leu Ala Ala Leu Pro Asp Asn Ser Met Ala Ser Val Leu Glu Ala Val

275 280 285Val Gly Pro Trp Gly Ala Ala Leu Ile Ser Leu Gly Leu Cys Leu Ser

290 295 300Val Leu Gly Ala Tyr Val Ser Trp Gln Met Leu Cys Ala Glu Pro Leu305 310 315 320Ala Leu Met Ala Met Asp Gly Leu Ile Pro Ser Lys Ile Gly Ala Ile

325 330 335Asn Ser Arg Gly Ala Ala Trp Met Ala Gln Leu Ile Ser Thr Ile Val

340 345 350Ile Gln Ile Phe Ile Ile Ile Phe Phe Leu Asn Glu Thr Thr Tyr Val

355 360 365Ser Met Val Gln Leu Ala Thr Asn Leu Tyr Leu Val Pro Tyr Leu Phe

370 375 380Ser Ala Phe Tyr Leu Val Met Leu Ala Thr Arg Gly Lys Gly Ile Thr385 390 395 400His Pro His Ala Gly Thr Arg Phe Asp Asp Ser Gly Pro Glu Ile Ser

405 410 415 Arg Arg Glu Asn Arg Lys His Leu Ile Val Gly Leu Val Ala Thr Val

420 425 430Tyr Ser Val Trp Leu Phe Tyr Ala Ala Glu Pro Gln Phe Val Leu Phe

435 440 445Gly Ala Met Ala Met Leu Pro Gly Leu Ile Pro Tyr Val Trp Thr Arg

450 455 460Ile Tyr Arg Gly Glu Gln Val Phe Asn Arg Phe Glu Ile Gly Val Val465 470 475 480Val Val Leu Val Val Ala Ala Ser Ala Gly Val Ile Gly Leu Val Asn

485 490 495Gly Ser Leu Ser Leu

500<210>53<21l>822<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (799)<223>RXA01394<400>53gagcaaagtg tccagttgaa tggggttcat gaagctatat taaaccatgt taagaaccaa 60tcattttact taagtacttc cataggtcac gatggtgatc atg gaa atc ttc att 115

Met Glu Ile Phe Ile

1 5aca ggt ctg ctt ttg ggg gcc agt ctt tta ctg tcc atc gga ccg cag 163Thr Gly Leu Leu Leu Gly Ala Ser Leu Leu Leu Ser Ile Gly Pro Gln

10 15 20aat gta ctg gtg att aaa caa gga att aag cgc gaa gga ctc att gcg 211Asn Val Leu Val Ile Lys Gln Gly Ile Lys Arg Glu Gly Leu Ile Ala

25 30 35gtt ctt ctc gtg tgt tta att tct gac gtc ttt ttg ttc atc gcc ggc 259Val Leu Leu Val Cys Leu Ile Ser Asp Val Phe Leu Phe Ile Ala Gly

40 45 50acc ttg ggc gtt gat ctt ttg tcc aat gcc gcg ccg atc gtg ctc gat 307Thr Leu Gly Val Asp Leu Leu Ser Asn Ala Ala Pro Ile Val Leu Asp

55 60 65att atg cgc tgg ggt ggc atc gct tac ctg tta tgg ttt gcc gtc atg 355Ile Met Arg Trp Gly Gly Ile Ala Tyr Leu Leu Trp Phe Ala Val Met 70 75 80 85gca gcg aaa gac gcc atg aca aac aag gtg gaa gcg cca cag atc att 403Ala Ala Lys Asp Ala Met Thr Asn Lys Val Glu Ala Pro Gln Ile Ile

90 95 100gaa gaa aca gaa cca acc gtg ccc gat gac acg cct ttg ggc ggt tcg 451Glu Glu Thr Glu Pro Thr Val Pro Asp Asp Thr Pro Leu Gly Gly Ser

105 110 115gcg gtg gcc act gac acg cgc aac cgg gtg cgg gtg gag gtg agc gtc 499Ala Val Ala Thr Asp Thr Arg Asn Arg Val Arg Val Glu Val Ser Val

120 125 130gat aag cag cgg gtt tgg gta aag ccc atg ttg atg gca atc gtg ctg 547Asp Lys Gln Arg Val Trp Val Lys Pro Met Leu Met Ala Ile Val Leu

135 140145acc tgg ttg aac ccg aat gcg tat ttg gac gcg ttt gtg ttt atc ggc 595Thr Trp Leu Asn Pro Asn Ala Tyr Leu Asp Ala Phe Val Phe Ile Gly150 155 160 165ggc gtc ggc gcg caa tac ggc gac acc gga cgg tgg att ttc gcc gct 643Gly Val Gly Ala Gln Tyr Gly Asp Thr Gly Arg Trp Ile Phe Ala Ala

170 175 180ggc gcg ttc gcg gca agc ctg atc tgg ttc ccg ctg gtg ggt ttc ggc 691Gly Ala Phe Ala Ala Ser Leu Ile Trp Phe Pro Leu Val Gly Phe Gly

185 190 195gca gca gca ttg tca cgc ccg ctg tcc agc ccc aag gtg tgg cgc tgg 739Ala Ala Ala Leu Ser Arg Pro Leu Ser Ser Pro Lys Val Trp Arg Trp

200 205 210atc aac gtc gtc gtg gca gtt gtg atg acc gca ttg gcc atc aaa ctg 787Ile Asn Val Val Val Ala Val Val Met Thr Ala Leu Ala Ile Lys Leu

215220225 atg ttg atg ggt tagttttcgc gggttttgga atc 822Met Leu Met Gly230<210>54<211>233<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>54Met Glu Ile Phe Ile Thr Gly Leu Leu Leu Gly Ala Ser Leu Leu Leu 151015 Ser Ile Gly Pro Gln Asn Val Leu Val Ile Lys Gln Gly Ile Lys Arg

20 25 30Glu Gly Leu Ile Ala Val Leu Leu Val Cys Leu Ile Ser Asp Val Phe

35 40 45Leu Phe Ile Ala Gly Thr Leu Gly Val Asp Leu Leu Ser Asn Ala Ala

50 55 60Pro Ile Val Leu Asp Ile Met Arg Trp Gly Gly Ile Ala Tyr Leu Leu 65 70 75 80Trp Phe Ala Val Met Ala Ala Lys Asp Ala Met Thr Asn Lys Val Glu

85 9095Ala Pro Gln Ile Ile Glu Glu Thr Glu Pro Thr Val Pro Asp Asp Thr

100 105 110Pro Leu Gly Gly Ser Ala Val Ala Thr Asp Thr Arg Asn Arg Val Arg

115 120 125Val Glu Val Ser Val Asp Lys Gln Arg Val Trp Val Lys Pro Met Leu

130 135 140Met Ala Ile Val Leu Thr Trp Leu Asn Pro Asn Ala Tyr Leu Asp Ala145 150 155 160Phe Val Phe Ile Gly Gly Val Gly Ala Gln Tyr Gly Asp Thr Gly Arg

165 170 175Trp Ile Phe Ala Ala Gly Ala Phe Ala Ala Ser Leu Ile Trp Phe Pro

180 185 190Leu Val Gly Phe Gly Ala Ala Ala Leu Ser Arg Pro Leu Ser Ser Pro

195 200 205Lys Val Trp Arg Trp Ile Asn Val Val Val Ala Val Val Met Thr Ala

210215220 Leu Ala Ile Lys Leu Met Leu Met Gly 225230<210>55<211>1026<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<1003><223>RXA00865<400>55ttatcggaat gtggcttggg cgattgttat gcaaaagttg ttaggttttt tgcggggttg 60tttaaccccc aaatgaggga agaaggtaac cttgaactct atg agc aca ggt tta 115

Met Ser Thr Gly Leu

1 5aca gct aag acc gga gta gag cac ttc ggc acc gtt gga gta gca atg 163Thr Ala Lys Thr Gly Val Glu His Phe Gly Thr Val Gly Val Ala Met

10 15 20gtt act cca ttc acg gaa tcc gga gac atc gat atc gct gct ggc cgc 211Val Thr Pro Phe Thr Glu Ser Gly Asp Ile Asp Ile Ala Ala Gly Arg

25 30 35gaa gtc gcg gct tat ttg gtt gat aag ggc ttg gat tct ttg gtt ctc 259Glu Val Ala Ala Tyr Leu Val Asp Lys Gly Leu Asp Ser Leu Val Leu

40 45 50gcg ggc acc act ggt gaa tcc cca acg aca acc gcc gct gaa aaa cta 307Ala Gly Thr Thr Gly Glu Ser Pro Thr Thr Thr Ala Ala Glu Lys Leu

55 60 65gaa ctg ctc aag gcc gtt cgt gag gaa gtt ggg gat cgg gcg aag ctc 355Glu Leu Leu Lys Ala Val Arg Glu Glu Val Gly Asp Arg Ala Lys Leu 70 75 80 85atc gcc ggt gtc gga acc aac aac acg cgg aca tct gtg gaa ctt gcg 403Ile Ala Gly Val Gly Thr Asn Asn Thr Arg Thr Ser Val Glu Leu Ala

90 95 100gaa gct gct gct tct gct ggc gca gac ggc ctt tta gtt gta act cct 451Glu Ala Ala Ala Ser Ala Gly Ala Asp Gly Leu Leu Val Val Thr Pro

105 110 115tat tac tcc aag ccg agc caa gag gga ttg ctg gcg cacttc ggt gca 499Tyr Tyr Ser Lys Pro Ser Gln Glu Gly Leu Leu Ala His Phe Gly Ala

120 125 130att gct gca gca aca gag gtt cca att tgt ctc tat gac att cct ggt 547Ile Ala Ala Ala Thr Glu Val Pro Ile Cys Leu Tyr Asp Ile Pro Gly

135 140 145cgg tca ggt att cca att gag tct gat acc atg aga cgc ctg agt gaa 595Arg Ser Gly Ile Pro Ile Glu Ser Asp Thr Met Arg Arg Leu Ser Glu150 155 160 165tta cct acg att ttg gcg gtc aag gac gcc aag ggt gac ctc gtt gca 643Leu Pro Thr Ile Leu Ala Val Lys Asp Ala Lys Gly Asp Leu Val Ala

170 175180gcc acg tca ttg atc aaa gaa acg gga ctt gcc tgg tat tca ggc gat 691Ala Thr Ser Leu Ile Lys Glu Thr Gly Leu Ala Trp Tyr Ser Gly Asp

185 190 195gac cca cta aac ctt gtt tgg ctt gct ttg ggc gga tca ggt ttc att 739Asp Pro Leu Asn Leu Val Trp Leu Ala Leu Gly Gly Ser Gly Phe Ile

200 205 210tcc gta att gga cat gca gcc ccc aca gca tta cgt gag ttg tac aca 787Ser Val Ile Gly His Ala Ala Pro Thr Ala Leu Arg Glu Leu Tyr Thr

215 220 225agc ttc gag gaa ggc gac ctc gtc cgt gcg cgg gaa atc aac gcc aaa 835Ser Phe Glu Glu Gly Asp Leu Val Arg Ala Arg Glu Ile Asn Ala Lys230 235 240 245cta tca ccg ctg gta gct gcc caa ggt cgc ttg ggt gga gtc agc ttg 883Leu Ser Pro Leu Val Ala Ala Gln Gly Arg Leu Gly Gly Val Ser Leu

250 255 260gca aaa gct gct ctg cgt ctg cag ggc atc aac gta gga gat cct cga 931Ala Lys Ala Ala Leu Arg Leu Gln Gly Ile Asn Val Gly Asp Pro Arg

265 270 275ctt cca att atg gct cca aat gag cag gaa ctt gag gct ctc cga gaa 979Leu Pro Ile Met Ala Pro Asn Glu Gln Glu Leu Glu Ala Leu Arg Glu

280 285 290gac atg aaa aaa gct gga gtt cta taaatatgaa tgattcccga aat 1026Asp Met Lys Lys Ala Gly Val Leu

295300<210>56<211>301<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>56Met Ser Thr Gly Leu Thr Ala Lys Thr Gly Val Glu His Phe Gly Thr 151015 Val Gly Val Ala Met Val Thr Pro Phe Thr Glu Ser Gly Asp Ile Asp

20 25 30Ile Ala Ala Gly Arg Glu Val AlaAla Tyr Leu Val Asp Lys Gly Leu

35 40 45Asp Ser Leu Val Leu Ala Gly Thr Thr Gly Glu Ser Pro Thr Thr Thr

50 55 60Ala Ala Glu Lys Leu Glu Leu Leu Lys Ala Val Arg Glu Glu Val Gly65 70 75 80Asp Arg Ala Lys Leu Ile Ala Gly Val Gly Thr Asn Asn Thr Arg Thr

85 90 95Ser Val Glu Leu Ala Glu Ala Ala Ala Ser Ala Gly Ala Asp Gly Leu

100 105 110Leu Val Val Thr Pro Tyr Tyr Ser Lys Pro Ser Gln Glu Gly Leu Leu

115 120 125Ala His Phe Gly Ala Ile Ala Ala Ala Thr Glu Val Pro Ile Cys Leu

130 135 140Tyr Asp Ile Pro Gly Arg Ser Gly Ile Pro Ile Glu Ser Asp Thr Met145 150 155 160Arg Arg Leu Ser Glu Leu Pro Thr Ile Leu Ala Val Lys Asp Ala Lys

165 170 175Gly Asp Leu Val Ala Ala Thr Ser Leu Ile Lys Glu Thr Gly Leu Ala

l80 185 190Trp Tyr Ser Gly Asp Asp Pro Leu Asn Leu Val Trp Leu Ala Leu Gly

195 200 205Gly Ser Gly Phe Ile Ser Val Ile Gly His Ala Ala Pro Thr Ala Leu

210 215 220Arg Glu Leu Tyr Thr Ser Phe Glu Glu Gly Asp Leu Val Arg Ala Arg225 230 235 240Glu Ile Asn Ala Lys Leu Ser Pro Leu Val Ala Ala Gln Gly Arg Leu

245 250 255Gly Gly Val Ser Leu Ala Lys Ala Ala Leu Arg Leu GlnGly Ile Asn

260 265 270Val Gly Asp Pro Arg Leu Pro Ile Met Ala Pro Asn Glu Gln Glu Leu

275 280 285Glu Ala Leu Arg Glu Asp Met Lys Lys Ala Gly Val Leu

290295300<210>57<211>1071<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1048)<223>RXS02021<400>57ttgggtcgcc gaggagatct aatcctggtt tgagttcaga gttcacaggt ttaagcctac 60aaaccttagt taaaacatga tggaagcggt cgattaaaaa atg agt gaa aac att 115

Met Ser Glu Asn Ile

1 5cgc gga gcc caa gca gtt gga atc gca aat atc gcc atg gac ggg acc 163Arg Gly Ala Gln Ala Val Gly Ile Ala Asn Ile Ala Met Asp Gly Thr

10 15 20atc ctg gac acg tgg tac cca gaa ccc caa att ttc aac ccg gat cag 211Ile Leu Asp Thr Trp Tyr Pro Glu Pro Gln Ile Phe Asn Pro Asp Gln

25 30 35tgg gct gaa cgc tac cca ttg gaa gtg ggc acc aca cgc ctc gga gca 259Trp Ala Glu Arg Tyr Pro Leu Glu Val Gly Thr Thr Arg Leu Gly Ala

40 45 50aac gaa ctc acc cca cgg atg ctg cag ttg gta aaa ctg gac caa gat 307Asn Glu Leu Thr Pro Arg Met Leu Gln Leu Val Lys Leu Asp Gln Asp

55 60 65cgc ctc gtc gaa cag gta gca gtc cgc acc gtt atc ccc gat ctg tct 355Arg Leu Val Glu Gln Val Ala Val Arg Thr Val Ile Pro Asp Leu Ser 70 75 80 85caa cct cca gta gac gcg cac gat gtt tac ctg cgc ctc cac ctg ctt 403Gln Pro Pro Val Asp Ala His Asp Val Tyr Leu Arg Leu His Leu Leu

90 95 100tcc cac cgg ctg gtc cgc ccc cac gaa atg cac atg caa aac acc ttg 451Ser His Arg Leu Val Arg Pro His Glu Met His Met Gln Asn Thr Leu

105 110 115gag ctg ctg tcc gac gtg gtg tgg aca aac aag ggc cct tgc ctt cct 499Glu Leu Leu Ser Asp Val Val Trp Thr Asn Lys Gly Pro Cys Leu Pro

120 125 130gaa aac ttt gag tgg gtg cgt ggt gct ctg cgg tcc cgc gga ctc atc 547Glu Asn Phe Glu Trp Val Arg Gly Ala Leu Arg Ser Arg Gly Leu Ile

135 140 145cac gtc tac tgt gtg gac cgt ctt ccc cgc atg gtc gac tat gtg gtt 595His Val Tyr Cys Val Asp Arg Leu Pro Arg Met Val Asp Tyr Val Val150 155 160 165ccc cct gga gtc cgc atc tcc gaa gca gaa cgc gtg cgc cta ggt gca 643Pro Pro Gly Val Arg Ile Ser Glu Ala Glu Arg Val Arg Leu Gly Ala

170 175 180tac ctt gct ccg ggt acc tct gtg ctg cgt gaa ggt ttc gtg tct ttc 691Tyr Leu Ala Pro Gly Thr Ser Val Leu Arg Glu Gly Phe Val Ser Phe

185 190 195aac tcc ggc acc ttg ggt gcc gca aag gtg gaa ggc cgc ctg agt tcc 739Asn Ser Gly Thr Leu Gly Ala Ala Lys Val Glu Gly Arg Leu Ser Ser

200 205 210ggt gtg gtc atc ggt gaa ggt tcc gag att gga ctg tct tct act att 787Gly Val Val Ile Gly Glu Gly Ser Glu Ile Gly Leu Ser Ser Thr Ile

215 220 225cag tcc ccg aga gat gaa cag cgc cgc cgt ttg ccg ttg agc atc ggc 835Gln Ser Pro Arg Asp Glu Gln Arg Arg Arg Leu Pro Leu Ser Ile Gly230 235 240245caa aac tgc aac ttt ggt gtc agc tcc gga atc atc gga gtc agt ctg 883Gln Asn Cys Asn Phe Gly Val Ser Ser Gly Ile Ile Gly Val Ser Leu

250 255 260gga gac aat tgc gac atc gga aat aac att gtc ttg gat gga gat acc 931Gly Asp Asn Cys Asp Ile Gly Asn Asn Ile Val Leu Asp Gly Asp Thr

265 270 275ccc att tgg ttc gca gcc gat gag gag tta cgc act atc gac tcc atc 979Pro Ile Trp Phe Ala Ala Asp Glu Glu Leu Arg Thr Ile Asp Ser Ile

280 285 290gaa ggc caa gca aat tgg tca atc aag cgt gaa tcc ggc ttc cat gag 1027Glu Gly Gln Ala Asn Trp Ser Ile Lys Arg Glu Ser Gly Phe His Glu

295300305 cca gtt gcc cgc ctc aaa gct tgacccattt tcataaccag tgc 1071Pro Val Ala Arg Leu Lys Ala 310315<210>58<211>316<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>58Met Ser Glu Asn Ile Arg Gly Ala Gln Ala Val Gly Ile Ala Asn Ile l 51015 Ala Met Asp Gly Thr Ile Leu Asp Thr Trp Tyr Pro Glu Pro Gln Ile

20 25 30Phe Asn Pro Asp Gln Trp Ala Glu Arg Tyr Pro Leu Glu Val Gly Thr

35 40 45Thr Arg Leu Gly Ala Asn Glu Leu Thr Pro Arg Met Leu Gln Leu Val

50 55 60Lys Leu Asp Gln Asp Arg Leu Val Glu Gln Val Ala Val Arg Thr Val 65 70 75 80Ile Pro Asp Leu Ser Gln Pro Pro Val Asp Ala His Asp Val Tyr Leu

85 90 95Arg Leu His Leu Leu Ser His Arg Leu Val Arg Pro His Glu Met His

100 105 110Met Gln Asn Thr Leu Glu Leu Leu Ser Asp Val Val Trp Thr Asn Lys

115 120 125Gly Pro Cys Leu Pro Glu Asn Phe Glu Trp Val Arg Gly Ala Leu Arg

130 135 140Ser Arg Gly Leu Ile His Val Tyr Cys Val Asp Arg Leu Pro Arg Met145 150 155 160Val Asp Tyr Val Val Pro Pro Gly Val Arg Ile Ser Glu Ala Glu Arg

165 170 175Val Arg Leu Gly Ala Tyr Leu Ala Pro Gly Thr Ser Val Leu Arg Glu

180 185 190Gly Phe Val Ser Phe Asn Ser Gly Thr Leu Gly Ala Ala Lys Val Glu

195 200 205Gly Arg Leu Ser Ser Gly Val Val Ile Gly Glu Gly Ser Glu Ile Gly

210 215 220Leu Ser Ser Thr Ile Gln Ser Pro Arg Asp Glu Gln Arg Arg Arg Leu225 230 235 240Pro Leu Ser Ile Gly Gln Asn Cys Asn Phe Gly Val Ser Ser Gly Ile

245 250 255Ile Gly Val Ser Leu Gly Asp Asn Cys Asp Ile Gly Asn Asn Ile Val

260 265 270Leu Asp Gly Asp Thr Pro Ile Trp Phe Ala Ala Asp Glu Glu Leu Arg

275 280 285Thr Ile Asp Ser Ile Glu Gly Gln Ala Asn Trp Ser Ile Lys Arg Glu

290295300 Ser Gly Phe His Glu Pro Val Ala Arg Leu Lys Ala 305310315<210>59<211>1296<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1273)<223>RXS02157<400>59gggtggaatt ggcacgatgg tgctgccgga tgtttttgat cgggagaatt atcctgaagg 60caccgttttt agaaaagacg acaaggatgg ggaactgtaa atg agc acg ctg gaa 115

Met Ser Thr Leu Glu

1 5act tgg cca cag gtc att att aat acg tac ggc acc cca cca gtt gag 163Thr Trp Pro Gln Val Ile Ile Asn Thr Tyr Gly Thr Pro Pro Val Glu

10 15 20ctg gtg tcc ggc aag ggc gca acc gtc act gat gac cag ggc aat gtc 211Leu Val Ser Gly Lys Gly Ala Thr Val Thr Asp Asp Gln Gly Asn Val

25 30 35tac atc gac ttg ctc gcg ggc atc gca gtc aac gcg ttg ggc cac gcc 259Tyr Ile Asp Leu Leu Ala Gly Ile Ala Val Asn Ala Leu Gly His Ala

40 45 50cac ccg gcg atc atc gag gcg gtc acc aac cag atc ggc caa ctt ggt 307His Pro Ala Ile Ile Glu Ala Val Thr Asn Gln Ile Gly Gln Leu Gly

55 60 65cac gtc tca aac ttg ttc gca tcc agg ccc gtc gtc gag gtc gcc gag 355His Val Ser Asn Leu Phe Ala Ser Arg Pro Val Val Glu Val Ala Glu 70 75 80 85gag ctc atc aag cgt ttt tcg ctt gac gac gcc acc ctc gcc gcg caa 403Glu Leu Ile Lys Arg Phe Ser Leu Asp Asp Ala Thr Leu Ala Ala Gln

90 95 100acc cgg gtt ttc ttc tgc aac tcg ggc gcc gaa gca aac gag gct gct 451Thr Arg Val Phe Phe Cys Asn Ser Gly Ala Glu Ala Asn Glu Ala Ala

105 110 115ttc aag att gca cgc ttg act ggt cgt tcc cgg att ctg gct gca gtt 499Phe Lys Ile Ala Arg Leu Thr Gly Arg Ser Arg Ile Leu Ala Ala Val

120 125 130cat ggt ttc cac ggc cgc acc atg ggt tcc ctc gcgctg act ggc cag 547His Gly Phe His Gly Arg Thr Met Gly Ser Leu Ala Leu Thr Gly Gln

135 140 145cca gac aag cgt gaa gcg ttc ctg cca atg cca agc ggt gtg gag ttc 595Pro Asp Lys Arg Glu Ala Phe Leu Pro Met Pro Ser Gly Val Glu Phe150 155 160 165tac cct tac ggc gac acc gat tac ttg cgc aaa atg gta gaa acc aac 643Tyr Pro Tyr Gly Asp Thr Asp Tyr Leu Arg Lys Met Val Glu Thr Asn

170 175 180cca acg gat gtg gct gct atc ttc ctc gag cca atc cag ggt gaa acg 691Pro Thr Asp Val Ala Ala Ile Phe Leu Glu Pro Ile Gln Gly Glu Thr

185 190 195ggc gtt gtt cca gca cct gaa gga ttc ctc aag gca gtg cgc gag ctg 739Gly Val Val Pro Ala Pro Glu Gly Phe Leu Lys Ala Val Arg Glu Leu

200 205 210tgc gat gag tac ggc atc ttg atg atc acc gat gaa gtc cag act ggc 787Cys Asp Glu Tyr Gly Ile Leu Met Ile Thr Asp Glu Val Gln Thr Gly

215 220 225gtt ggc cgt acc ggc gat ttc ttt gca cat cag cac gat ggc gtt gtt 835Val Gly Arg Thr Gly Asp Phe Phe Ala His Gln His Asp Gly Val Val230 235 240 245ccc gat gtg gtg acc atg gcc aag gga ctt ggc ggc ggt ctt ccc atc 883Pro Asp Val Val Thr Met Ala Lys Gly Leu Gly Gly Gly Leu Pro Ile

250 255 260ggt gct tgt ttg gcc act ggc cgt gca gct gaa ttg atg acc cca ggc 931Gly Ala Cys Leu Ala Thr Gly Arg Ala Ala Glu Leu Met Thr Pro Gly

265 270 275aag cac ggc acc act ttc ggt ggc aac cca gtt gct tgt gca gct gcc 979Lys His Gly Thr Thr Phe Gly Gly Asn Pro Val Ala Cys Ala Ala Ala

280 285 290aag gca gtg ctg tct gtt gtc gat gac gct ttc tgc gca gaa gtt gcc 1027Lys Ala Val Leu Ser Val Val Asp Asp Ala Phe Cys Ala Glu Val Ala

295 300 305cgc aag ggc gag ctg ttc aag gaa ctt ctt gcc aag gtt gac ggc gtt 1075Arg Lys Gly Glu Leu Phe Lys Glu Leu Leu Ala Lys Val Asp Gly Val310 315 320 325gta gac gtc cgt ggc agg ggc ttg atg ttg ggc gtg gtg ctg gag cgc 1123Val Asp Val Arg Gly Arg Gly Leu Met Leu Gly Val Val Leu Glu Arg

330 335 340gac gtc gca aag caa gct gtt ctt gat ggt ttt aag cac ggc gtt att 1171Asp Val Ala Lys Gln Ala Val Leu Asp Gly Phe Lys His Gly Val Ile

345 350 355ttg aat gca ccg gcg gac aac att atc cgt ttg acc ccg ccg ctg gtg 1219Leu Asn Ala Pro Ala Asp Asn Ile Ile Arg Leu Thr Pro Pro Leu Val

360 365 370atc acc gac gaa gaa atc gca gac gca gtc aag gct att gcc gag aca 1267Ile Thr Asp Glu Glu Ile Ala Asp Ala Val Lys Ala Ile Ala Glu Thr

375380385 atc gca taaaggactc aaacttatga ctt 1296Ile Ala390<210>60<211>391<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>60Met Ser Thr Leu Glu Thr Trp Pro Gln Val Ile Ile Asn Thr Tyr Gly 151015 Thr Pro Pro Val Glu Leu Val Ser Gly Lys Gly Ala Thr Val Thr Asp

20 25 30Asp Gln Gly Asn Val Tyr Ile Asp Leu Leu Ala Gly Ile Ala Val Asn

35 40 45Ala Leu Gly His Ala His Pro Ala Ile Ile Glu Ala Val Thr Asn Gln

50 55 60Ile Gly Gln Leu Gly His Val Ser Asn Leu Phe Ala Ser Arg Pro Val 65 70 75 80Val Glu Val Ala Glu Glu Leu Ile Lys Arg Phe Ser Leu Asp Asp Ala

85 90 95Thr Leu Ala Ala Gln Thr Arg Val Phe Phe Cys Asn Ser Gly Ala Glu

100 105 110Ala Asn Glu Ala Ala Phe Lys Ile Ala Arg Leu Thr Gly Arg Ser Arg

115 120 125Ile Leu Ala Ala Val His Gly Phe His Gly Arg Thr Met Gly Ser Leu

130 135 140Ala Leu Thr Gly Gln Pro Asp Lys Arg Glu Ala Phe Leu Pro Met Pro145 150 155 160Ser Gly Val Glu Phe Tyr Pro Tyr Gly Asp Thr Asp Tyr Leu Arg Lys

165 170 175Met Val Glu Thr Asn Pro Thr Asp Val Ala Ala Ile Phe Leu Glu Pro

180 185 190Ile Gln Gly Glu Thr Gly Val Val Pro Ala Pro Glu Gly Phe Leu Lys

195 200 205Ala Val Arg Glu Leu Cys Asp Glu Tyr Gly Ile Leu Met Ile Thr Asp

210 215 220Glu Val Gln Thr Gly Val Gly Arg Thr Gly Asp Phe Phe Ala His Gln225 230 235 240His Asp Gly Val Val Pro Asp Val Val Thr Met Ala Lys Gly Leu Gly

245 250 255Gly Gly Leu Pro Ile Gly Ala Cys Leu Ala Thr Gly Arg Ala Ala Glu

260 265 270Leu Met Thr Pro Gly Lys His Gly Thr Thr Phe Gly Gly Asn Pro Val

275 280 285Ala Cys Ala Ala Ala Lys Ala Val Leu Ser Val ValAsp Asp Ala Phe

290 295 300Cys Ala Glu Val Ala Arg Lys Gly Glu Leu Phe Lys Glu Leu Leu Ala305 310 315 320Lys Val Asp Gly Val Val Asp Val Arg Gly Arg Gly Leu Met Leu Gly

325 330 335Val Val Leu Glu Arg Asp Val Ala Lys Gln Ala Val Leu Asp Gly Phe

340 345 350Lys His Gly Val Ile Leu Asn Ala Pro Ala Asp Asn Ile Ile Arg Leu

355 360 365Thr Pro Pro Leu Val Ile Thr Asp Glu Glu Ile Ala Asp Ala Val Lys

370375380 Ala Ile Ala Glu Thr Ile Ala 385390<210>61<211>1008<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (985)<223>RXC00733<400>6lacggcgaggt tgtcggtatt ggaacgcaca cgaatttgct gaacacgtgc ggtacctacc 60gtgaaattgt tgaatcccaa gagactgcgc aggcgcaatc atg agt aat act gca 115

Met Ser Asn Thr Ala

1 5ggc ccc cgc ggg cgt tcc cat cag gca gac gcc gcg ccg aat caa aag 163Gly Pro Arg Gly Arg Ser His Gln Ala Asp Ala Ala Pro Asn Gln Lys

l0 15 20gca cag aat ttc gga cca tct gcc aaa agg ctt ttc gga att cta ggc 211Ala Gln Asn Phe Gly Pro Ser Ala Lys Arg Leu Phe Gly Ile Leu Gly

25 30 35cat gac cgt aac acc tta att ttt gtt atc ttc cta gcc gtc ctg agc 259His Asp Arg Asn Thr Leu Ile Phe Val Ile Phe Leu Ala Val Leu Ser

40 45 50gtt gga ctt acc gtc ttg ggc cca tgg ttg ctg ggt aaa gcc acc aac 307Val Gly Leu Thr Val Leu Gly Pro Trp Leu Leu Gly Lys Ala Thr Asn

55 60 65gtg gtg ttt gaa gga ttc cta tct aag cgc atg ccg gct ggt gcg tca 355Val Val Phe Glu Gly Phe Leu Ser Lys Arg Met Pro Ala Gly Ala Ser 70 75 80 85aag gaa gat atc atc gcg cag ttg cag gct gca ggt aaa cat aat cag 403Lys Glu Asp Ile Ile Ala Gln Leu Gln Ala Ala Gly Lys His Asn Gln

90 95 100gct tcc atg atg gaa gac atg aac ctt gtt cca ggc tca ggc att gat 451Ala Ser Met Met Glu Asp Met Asn Leu Val Pro Gly Ser Gly Ile Asp

105 110 115ttt gaa aaa tta gcc atg atc ctc gga ctg gtg atc ggt gct tat ctc 499Phe Glu Lys Leu Ala Met Ile Leu Gly Leu Val Ile Gly Ala Tyr Leu

120 125 130atc ggt agc ctg ttg tcg ttg ttc cag gcg cgg atg ctc aac cgc atc 547Ile Gly Ser Leu Leu Ser Leu Phe Gln Ala Arg Met Leu Asn Arg Ile

135 140 145gtg caa agt gcc atg cac cgg ctg cgc atg gag gtg gag gaa aaa atc 595Val Gln Ser Ala Met His Arg Leu Arg Met Glu Val Glu Glu Lys Ile150 155 160 165cac cgc cta ccg ctg agc tat ttc gat tcc atc aaa cgt ggt gat ctg 643His Arg Leu Pro Leu Ser Tyr Phe Asp Ser Ile Lys Arg Gly Asp Leu

170 175 180ctt agc cgt gtg acc aac gat gtg gat aat atc ggt caa tcc ctg caa 691Leu Ser Arg Val Thr Asn Asp Val Asp Asn Ile Gly Gln Ser Leu Gln

185 190 195caa acc ttg tca cag gcg atc act tcc cta ctg acc gtc atc ggt gtg 739Gln Thr Leu Ser Gln Ala Ile Thr Ser Leu Leu Thr Val Ile Gly Val

200 205 210ttg gtg atg atg ttt atc atc tcc cca ctg ctc gca ctc gtg gcg ctg 787Leu Val Met Met Phe Ile Ile Ser Pro Leu Leu Ala Leu Val Ala Leu

215 220 225gta tcc att ccg gtc acc atc gtg gtc act gtg gtg gtt gcg agc cgt 835Val Ser Ile Pro Val Thr Ile Val Val Thr Val Val Val Ala Ser Arg230 235 240 245tcc cag aaa ctc ttt gcg gaa cag tgg aag cag acc ggt att ttg aat 883Ser Gln Lys Leu Phe Ala Glu Gln Trp Lys Gln Thr Gly Ile Leu Asn

250 255 260gcg cgc ctg gag gaa acc tac tct ggc cac gcc gtg gtt aag gtt ttc 931Ala Arg Leu Glu Glu Thr Tyr Ser Gly His Ala Val Val Lys Val Phe

265 270 275gga cac caa aag gat gtt caa gaa gca ttc gag gaa gaa aat caa gct 979Gly His Gln Lys Asp Val Gln Glu Ala Phe Glu Glu Glu Asn Gln Ala

280 285 290tgt gta taaggccagc tttggtgccc agt 1008Cys Val

295<210>62<211>295<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>62Met Ser Asn Thr Ala Gly Pro Arg Gly Arg Ser His Gln Ala Asp Ala 151015 Ala Pro Asn Gln Lys Ala Gln Asn Phe Gly Pro Ser Ala Lys Arg Leu

20 25 30Phe Gly Ile Leu Gly His Asp Arg Asn Thr Leu Ile Phe Val Ile Phe

35 40 45Leu Ala Val Leu Ser Val Gly Leu Thr Val Leu Gly Pro Trp Leu Leu

50 55 60Gly Lys Ala Thr Asn Val Val Phe Glu Gly Phe Leu Ser Lys Arg Met 65 70 75 80Pro AlaGly Ala Ser Lys Glu Asp Ile Ile Ala Gln Leu Gln Ala Ala

85 90 95Gly Lys His Asn Gln Ala Ser Met Met Glu Asp Met Asn Leu Val Pro

100 105 110Gly Ser Gly Ile Asp Phe Glu Lys Leu Ala Met Ile Leu Gly Leu Val

115 120 125Ile Gly Ala Tyr Leu Ile Gly Ser Leu Leu Ser Leu Phe Gln Ala Arg

130 135 140Met Leu Asn Arg Ile Val Gln Ser Ala Met His Arg Leu Arg Met Glu145 150 155 160Val Glu Glu Lys Ile His Arg Leu Pro Leu Ser Tyr Phe Asp Ser Ile

165 170 175Lys Arg Gly Asp Leu Leu Ser Arg Val Thr Asn Asp Val Asp Asn Ile

180 185 190Gly Gln Ser Leu Gln Gln Thr Leu Ser Gln Ala Ile Thr Ser Leu Leu

195 200 205Thr Val Ile Gly Val Leu Val Met Met Phe Ile Ile Ser Pro Leu Leu

210 215 220Ala Leu Val Ala Leu Val Ser Ile Pro Val Thr Ile Val Val Thr Val225 230 235 240Val Val Ala Ser Arg Ser Gln Lys Leu Phe Ala Glu Gln Trp Lys Gln

245 250 255Thr Gly Ile Leu Asn Ala Arg Leu Glu Glu Thr Tyr Ser Gly His Ala

260 265 270Val Val Lys Val Phe Gly His Gln Lys Asp Val Gln Glu Ala Phe Glu

275 280 285Glu Glu Asn Gln Ala Cys Val

290295<210>63<211>426<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (426)<223>RXC00861<400>63atg gct cct cac aag gtc atg ctg att acc act ggt act cag ggt gag 48Met Ala Pro His Lys Val Met Leu Ile Thr Thr Gly Thr Gln Gly Glu 151015 cct atg gct gcg ctg tct cgc atg gcg cgt cgt gag cac cga cag atc 96Pro Met Ala Ala Leu Ser Arg Met Ala Arg Arg Glu His Arg Gln Ile

20 25 30act gtc cgt gat gga gac ttg att atc ctt tct tcc tcc ctg gtt cca 144Thr Val Arg Asp Gly Asp Leu Ile Ile Leu Ser Ser Ser Leu Val Pro

35 40 45ggt aac gaa gaa gca gtg ttc ggt gtc atc aac atg ctg gct cag atc 192Gly Asn Glu Glu Ala Val Phe Gly Val Ile Asn Met Leu Ala Gln Ile

50 55 60ggt gca act gtt gtt acc ggt cgc gac gcc aag gtg cac acc tcg ggc 240Gly Ala Thr Val Val Thr Gly Arg Asp Ala Lys Val His Thr Ser Gly 65 70 75 80cac ggc tac tcc gga gag ctg ttg ttc ttg tac aac gcc gct cgt ccg 288His Gly Tyr Ser Gly Glu Leu Leu Phe Leu Tyr Asn Ala Ala Arg Pro

85 90 95aag aac gct atg cct gtc cac ggc gag tgg cgc cac ctg cgc gcc aac 336Lys Asn Ala Met Pro Val His Gly Glu Trp Arg His Leu Arg Ala Asn

l00 105 110aag gaa ctg gct atc tcc act ggt gtt aac cgc gac aac gtt gtg ctt 384Lys Glu Leu Ala Ile Ser Thr Gly Val Asn Arg Asp Asn Val Val Leu

115 120 125gca caa aac ggt gtt gtg gtt gat atg gtc aac ggt cgc gca 426Ala Gln Asn Gly Val Val Val Asp Met Val Asn Gly Arg Ala

130135140<210>64<211>142<212>PRT<213>Corynebacteriumglutamicum (Corynebacterium glutamicum)<400>64Met Ala Pro His Lys Val Met Leu Ile Thr Thr Gly Thr Gln Gly Glu 151015 Pro Met Ala Ala Leu Ser Arg Met Ala Arg Arg Glu His Arg Gln Ile

20 25 30Thr Val Arg Asp Gly Asp Leu Ile Ile Leu Ser Ser Ser Leu Val Pro

35 40 45Gly Asn Glu Glu Ala Val Phe Gly Val Ile Asn Met Leu Ala Gln Ile

50 55 60Gly Ala Thr Val Val Thr Gly Arg Asp Ala Lys Val His Thr Ser Gly 65 70 75 80His Gly Tyr Ser Gly Glu Leu Leu Phe Leu Tyr Asn Ala Ala Arg Pro

85 90 95Lys Asn Ala Met Pro Val His Gly Glu Trp Arg His Leu Arg Ala Asn

100 105 110Lys Glu Leu Ala Ile Ser Thr Gly Val Asn Arg Asp Asn Val Val Leu

115 120 125Ala Gln Asn Gly Val Val Val Asp Met Val Asn Gly Arg Ala

130135140<210>65<211>1066<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1066)<223>RXC00866<400>65gcatcaacgt aggagatcct cgacttccaa ttatggctcc aaatgagcag gaacttgagg 60ctctccgaga agacatgaaa aaagctggag ttctataaat atg aat gat tcc cga 115

Met Asn Asp Ser Arg

l 5aat cgc ggc cgg aag gtt acc cgc aag gcg ggc cca cca gaa gct ggt 163Asn Arg Gly Arg Lys Val Thr Arg Lys Ala Gly Pro Pro Glu Ala Gly

10 15 20cag gaa aac cat ctg gat acc cctgtc ttt cag gca cca gat gct tcc 211Gln Glu Asn His Leu Asp Thr Pro Val Phe Gln Ala Pro Asp Ala Ser

25 30 35tct aac cag agc gct gta aaa gct gag acc gcc gga aac gac aat cgg 259Ser Asn Gln Ser Ala Val Lys Ala Glu Thr Ala Gly Asn Asp Asn Arg

40 45 50gat gct gcg caa ggt gct caa gga tcc caa gat tct cag ggt tcc cag 307Asp Ala Ala Gln Gly Ala Gln Gly Ser Gln Asp Ser Gln Gly Ser Gln

55 60 65aac gct caa ggt tcc cag aac cgc gag tcc gga aac aac aac cgc aac 355Asn Ala Gln Gly Ser Gln Asn Arg Glu Ser Gly Asn Asn Asn Arg Asn 70 75 80 85cgt tcc aac aac aac cgt cgc ggt ggt cgt gga cgt cgt gga tcc gga 403Arg Ser Asn Asn Asn Arg Arg Gly Gly Arg Gly Arg Arg Gly Ser Gly

90 95 100aac gcc aat gag ggc gcg aac aac aac agc ggt aac cag aac cgt cag 451Asn Ala Asn Glu Gly Ala Asn Asn Asn Ser Gly Asn Gln Asn Arg Gln

105 110 115ggc gga aac cgt ggc aac cgc ggt ggc gga cgc cga aac gtt gtt aag 499Gly Gly Asn Arg Gly Asn Arg Gly Gly Gly Arg Arg Asn Val Val Lys

120 125 130tcg atg cag ggt gcg gat ctg acc cag cgc ctg cca gag cca cca aag 547Ser Met Gln Gly Ala Asp Leu Thr Gln Arg Leu Pro Glu Pro Pro Lys

135 140 145gca ccg gca aac ggt ctg cgt att tac gca ctt ggt ggc att tcc gaa 595Ala Pro Ala Asn Gly Leu Arg Ile Tyr Ala Leu Gly Gly Ile Ser Glu150 155 160 165atc ggt cgc aac atg acc gtg ttt gag tac aac aac cgt ctg ctc atc 643Ile Gly Arg Asn Met Thr Val Phe Glu Tyr Asn Asn Arg Leu Leu Ile

170 175 180gtg gac tgt ggt gtg ctc ttc cca tct tca ggt gag cca ggc gtt gac 691Val Asp Cys Gly Val Leu Phe Pro Ser Ser Gly Glu Pro Gly Val Asp

185 190 195ctg att ctt cct gac ttc ggc cca att gag gat cac ctg cac cgc gtc 739Leu Ile Leu Pro Asp Phe Gly Pro Ile Glu Asp His Leu His Arg Val

200 205 210gat gca ttg gtg gtt act cac gga cac gaa gac cac att ggt gct att 787Asp Ala Leu Val Val Thr His Gly His Glu Asp His Ile Gly Ala Ile

215 220 225ccc tgg ctg ctg aag ctg cgc aac gat atc cca atc ttg gca tcc cgt 835Pro Trp Leu Leu Lys Leu Arg Asn Asp Ile Pro Ile Leu Ala Ser Arg230 235 240 245ttc acc ttg gct ctg att gca gct aag tgt aag gaa cac cgt cag cgt 883Phe Thr Leu Ala Leu Ile Ala Ala Lys Cys Lys Glu His Arg Gln Arg

250 255 260ccg aag ctg atc gag gtc aac gag cag tcc aat gag gac cgc gga ccg 931Pro Lys Leu Ile Glu Val Asn Glu Gln Ser Asn Glu Asp Arg Gly Pro

265 270 275ttc aac att cgc ttc tgg gct gtt aac cac tcc atc cca gac tgc ctt 979Phe Asn Ile Arg Phe Trp Ala Val Asn His Ser Ile Pro Asp Cys Leu

280 285 290ggt ctt gct atc aag act cct gct ggt ttg gtc atc cac acc ggt gac 1027Gly Leu Ala Ile Lys Thr Pro Ala Gly Leu Val Ile His Thr Gly Asp

295300305 atc aag ctg gat cag act cct cct gat gga cgc cca act 1066Ile Lys Leu Asp Gln Thr Pro Pro Asp Gly Arg Pro Thr 310315320<210>66<211>322<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>66Met Asn Asp Ser Arg Asn Arg Gly Arg Lys Val Thr Arg Lys Ala Gly 151015 Pro Pro Glu Ala Gly Gln Glu Asn His Leu Asp Thr Pro Val Phe Gln

20 25 30Ala Pro Asp Ala Ser Ser Asn Gln Ser Ala Val Lys Ala Glu Thr Ala

35 40 45Gly Asn Asp Asn Arg Asp Ala Ala Gln Gly Ala Gln Gly Ser Gln Asp

50 55 60Ser Gln Gly Ser Gln Asn Ala Gln Gly Ser Gln Asn Arg Glu Ser Gly 65 70 75 80Asn Asn Asn Arg Asn Arg Ser Asn Asn Asn Arg Arg Gly Gly Arg Gly

85 90 95Arg Arg Gly Ser Gly Asn Ala Asn Glu Gly Ala Asn Asn Asn Ser Gly

100 105 110Asn Gln Asn Arg Gln Gly Gly Asn Arg Gly Asn Arg Gly Gly Gly Arg

115 120 125Arg Asn Val Val Lys Ser Met Gln Gly Ala Asp Leu Thr Gln Arg Leu

130 135 140Pro Glu Pro Pro Lys Ala Pro Ala Asn Gly Leu Arg Ile Tyr Ala Leu145 150 155 160Gly Gly Ile Ser Glu Ile Gly Arg Asn Met Thr Val Phe Glu Tyr Asn

165 170 175Asn Arg Leu Leu Ile Val Asp Cys Gly Val Leu Phe Pro Ser Ser Gly

180 185 190Glu Pro Gly Val Asp Leu Ile Leu Pro Asp Phe Gly Pro Ile Glu Asp

195 200 205His Leu His Arg Val Asp Ala Leu Val Val Thr His Gly His Glu Asp

210 215 220His Ile Gly Ala Ile Pro Trp Leu Leu Lys Leu Arg Asn Asp Ile Pro225 230 235240Ile Leu Ala Ser Arg Phe Thr Leu Ala Leu Ile Ala Ala Lys Cys Lys

245 250 255Glu His Arg Gln Arg Pro Lys Leu Ile Glu Val Asn Glu Gln Ser Asn

260 265 270Glu Asp Arg Gly Pro Phe Asn Ile Arg Phe Trp Ala Val Asn His Ser

275 280 285Ile Pro Asp Cys Leu Gly Leu Ala Ile Lys Thr Pro Ala Gly Leu Val

290295300 Ile His Thr Gly Asp Ile Lys Leu Asp Gln Thr Pro Pro Asp Gly Arg 305310315320 Pro Thr<210>67<211>1527<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<1504)<223>RXC02095<400>67ctctcttggt cctctcccca cccattttta agtactcaag acccttccaa cagaaaggat 60tactccccca acaggctcaa aaatactgaa aggctcacgc atg aaa act gag caa 115

Met Lys Thr Glu Gln

1 5tcc caa aaa gca caa tta gcc cct aag aaa gca cct gaa aag cca caa 163Ser Gln Lys Ala Gln Leu Ala Pro Lys Lys Ala Pro Glu Lys Pro Gln

10 15 20cgc atc cgc caa ctt att tcc gtg gcg tgg cag cga cct tgg ctc acc 211Arg Ile Arg Gln Leu Ile Ser Val Ala Trp Gln Arg Pro Trp Leu Thr

25 30 35tca ttc acc gta atc agc gct tta gct gca acg ttg ttt gaa ctt aca 259Ser Phe Thr Val Ile Ser Ala Leu Ala Ala Thr Leu Phe Glu Leu Thr

40 45 50ctt cct ctt ttg acc ggt ggc gcc atc gat atc gcg ctc gga aat acc 307Leu Pro Leu Leu Thr Gly Gly Ala Ile Asp Ile Ala Leu Gly Asn Thr

5560 65gga gat act tta acc act gac ctg ctg gac cgg ttc act ccg agt gga 355Gly Asp Thr Leu Thr Thr Asp Leu Leu Asp Arg Phe Thr Pro Ser Gly 70 75 80 85tta agc gtg ttg acc agc gtc att gcc ctt atc gtg ctt ctc gcg ttg 403Leu Ser Val Leu Thr Ser Val Ile Ala Leu Ile Val Leu Leu Ala Leu

90 95 100ctt cgc tat gcc agt caa ttt gga cgg cga tac acc gca ggc aag ctc 451Leu Arg Tyr Ala Ser Gln Phe Gly Arg Arg Tyr Thr Ala Gly Lys Leu

105 110 115agc atg ggg gta cag cat gat gtc cgg ctt aaa acg atg cgc tca ttg 499Ser Met Gly Val Gln His Asp Val Arg Leu Lys Thr Met Arg Ser Leu

120 125 130cag aac ctc gat ggg cca ggt cag gac tct att cgc aca ggc caa gta 547Gln Asn Leu Asp Gly Pro Gly Gln Asp Ser Ile Arg Thr Gly Gln Val

135 140 145gtc agt cgg tcc att tcg gat atc aac atg gtg caa agc ctt gtg gcg 595Val Ser Arg Ser Ile Ser Asp Ile Asn Met Val Gln Ser Leu Val Ala150 155 160 165atg ttg ccg atg ttg atc gga aat gtg gtc aag ctt gtg ctc act ttg 643Met Leu Pro Met Leu Ile Gly Asn Val Val Lys Leu Val Leu Thr Leu

170 175 180gtg atc atg ctg gct att tcc ccg ccg ctg acc atc atc gct gca gtg 691Val Ile Met Leu Ala Ile Ser Pro Pro Leu Thr Ile Ile Ala Ala Val

185 190 195ttg gtg cct ttg ctg ttg tgg gcc gtg gcc tat tcg cga aaa gcg ctt 739Leu Val Pro Leu Leu Leu Trp Ala Val Ala Tyr Ser Arg Lys Ala Leu

200 205 210ttt gcg tcc acg tgg tcg gcc cag caa aag gct gcg gat ctg acc act 787Phe Ala Ser Thr Trp Ser Ala Gln Gln Lys Ala Ala Asp Leu Thr Thr

215 220 225cat gtg gaa gaa act gtc acg ggt atc cgc gtg gtc aag gca ttt gcg 835His Val Glu Glu Thr Val Thr Gly Ile Arg Val Val Lys Ala Phe Ala230 235 240 245cag gaa gac cgc gag acc gac aaa ttg gat ctc acc gca cgt gag tta 883Gln Glu Asp Arg Glu Thr Asp Lys Leu Asp Leu Thr Ala Arg Glu Leu

250 255 260ttt gcc cag cgc atg cgc act gca cgt ctg acg gca aag ttc atc ccc 931Phe Ala Gln Arg Met Arg Thr Ala Arg Leu Thr Ala Lys Phe Ile Pro

265 270 275atg gtt gag cag ctt ccg cag ctt gct ttg gtg gtc aac att gtt ggc 979Met Val Glu Gln Leu Pro Gln Leu Ala Leu Val Val Asn Ile Val Gly

280 285 290ggt ggc tat ttg gcc atg act ggt cac atc acg gtg ggc acg ttt gtg 1027Gly Gly Tyr Leu Ala Met Thr Gly His Ile Thr Val Gly Thr Phe Val

295 300 305gcg ttt tct tcc tat ctc act agc ttg tcg gcg gtg gct agg tcc ctg 1075Ala Phe Ser Ser Tyr Leu Thr Ser Leu Ser Ala Val Ala Arg Ser Leu310 315 320 325tcg ggc atg ctc atg cgc gtg cag ttg gcg ctg tct tct gtg gag cgc 1123Ser Gly Met Leu Met Arg Val Gln Leu Ala Leu Ser Ser Val Glu Arg

330 335 340atc ttt gaa gtc att gat ctt cag cct gaa cgc acc gat cct gca cae 1171Ile Phe Glu Val Ile Asp Leu Gln Pro Glu Arg Thr Asp Pro Ala His

345 350 355ccc ctg tca ctt ccc gac act ccc ctg ggt ctg tcg ttc aac aac gta 1219Pro Leu Ser Leu Pro Asp Thr Pro Leu Gly Leu Ser Phe Asn Asn Val

360365 370gat ttc cgt ggg att ctc aac ggt ttt gag ctg ggt gtt cag gcc ggt 1267Asp Phe Arg Gly Ile Leu Asn Gly Phe Glu Leu Gly Val Gln Ala Gly

375 380 385gaa acc gtt gtg ttg gtg ggc cct cca ggt tca ggc aag acc atg gct 1315Glu Thr Val Val Leu Val Gly Pro Pro Gly Ser Gly Lys Thr Met Ala390 395 400 405gtg cag ctt gct gga aac ttt tat caa cca gac agc ggc cac atc gcc 1363Val Gln Leu Ala Gly Asn Phe Tyr Gln Pro Asp Ser Gly His Ile Ala

410 415 420ttt gat agc aac ggc cat cgc act cgc ttc gac gac ctc acc cac agc 1411Phe Asp Ser Asn Gly His Arg Thr Arg Phe Asp Asp Leu Thr His Ser

425 430 435gat atc cgc agg aat ctc atc gcg gtt ttt gat gag ccg ttc ttg tac 1459Asp Ile Arg Arg Asn Leu Ile Ala Val Phe Asp Glu Pro Phe Leu Tyr

440 445 450tcc tcc tcc ata ccg cga gaa cat ctc gat ggg ttt gga tgt cag 1504Ser Ser Ser Ile Pro Arg Glu His Leu Asp Gly Phe Gly Cys Gln

455460465 tgatgagcag atcgaacacg cag 1527<210>68<211>468<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>68Met Lys Thr Glu Gln Ser Gln Lys Ala Gln Leu Ala Pro Lys Lys Ala 15l 015 Pro Glu Lys Pro Gln Arg Ile Arg Gln Leu Ile Ser Val Ala Trp Gln

20 25 30Arg Pro Trp Leu Thr Ser Phe Thr Val Ile Ser Ala Leu Ala Ala Thr

35 40 45Leu Phe Glu Leu Thr Leu Pro Leu Leu Thr Gly Gly Ala Ile Asp Ile

50 55 60Ala Leu Gly Asn Thr Gly Asp Thr Leu Thr Thr Asp Leu Leu Asp Arg 6570 75 80Phe Thr Pro Ser Gly Leu Ser Val Leu Thr Ser Val Ile Ala Leu Ile

85 90 95Val Leu Leu Ala Leu Leu Arg Tyr Ala Ser Gln Phe Gly Arg Arg Tyr

100 105 110Thr Ala Gly Lys Leu Ser Met Gly Val Gln His Asp Val Arg Leu Lys

115 120 125Thr Met Arg Ser Leu Gln Asn Leu Asp Gly Pro Gly Gln Asp Ser Ile

130 135 140Arg Thr Gly Gln Val Val Ser Arg Ser Ile Ser Asp Ile Asn Met Val145 150 155 160Gln Ser Leu Val Ala Met Leu Pro Met Leu Ile Gly Asn Val Val Lys

165 170 175Leu Val Leu Thr Leu Val Ile Met Leu Ala Ile Ser Pro Pro Leu Thr

180 185 190Ile Ile Ala Ala Val Leu Val Pro Leu Leu Leu Trp Ala Val Ala Tyr

195 200 205Ser Arg Lys Ala Leu Phe Ala Ser Thr Trp Ser Ala Gln Gln Lys Ala

210 215 220Ala Asp Leu Thr Thr His Val Glu Glu Thr Val Thr Gly Ile Arg Val225 230 235 240Val Lys Ala Phe Ala Gln Glu Asp Arg Glu Thr Asp Lys Leu Asp Leu

245 250 255Thr Ala Arg Glu Leu Phe Ala Gln Arg Met Arg Thr Ala Arg Leu Thr

260 265 270Ala Lys Phe Ile Pro Met Val Glu Gln Leu Pro Gln Leu Ala Leu Val

275 280 285Val Asn Ile Val Gly Gly Gly Tyr Leu Ala Met Thr Gly His Ile Thr

290 295 300Val Gly Thr Phe Val Ala Phe Ser Ser Tyr Leu Thr Ser Leu Ser Ala305 310 315 320Val Ala Arg Ser Leu Ser Gly Met Leu Met Arg Val Gln Leu Ala Leu

325 330 335Ser Ser Val Glu Arg Ile Phe Glu Val Ile Asp Leu Gln Pro Glu Arg

340 345 350Thr Asp Pro Ala His Pro Leu Ser Leu Pro Asp Thr Pro Leu Gly Leu

355 360 365Ser Phe Asn Asn Val Asp Phe Arg Gly Ile Leu Asn Gly Phe Glu Leu

370 375 380Gly Val Gln Ala Gly Glu Thr Val Val Leu Val Gly Pro Pro Gly Ser385 390 395 400Gly Lys Thr Met Ala Val Gln Leu Ala Gly Asn Phe Tyr Gln Pro Asp

405 410 415Ser Gly His Ile Ala Phe Asp Ser Asn Gly His Arg Thr Arg Phe Asp

420 425 430Asp Leu Thr His Ser Asp Ile Arg Arg Asn Leu Ile Ala Val Phe Asp

435 440 445Glu Pro Phe Leu Tyr Ser Ser Ser Ile Pro Arg Glu His Leu Asp Gly

450455460 Phe Gly Cys Gln465<210>69<211>295<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(84). (272)<223>RXC03185<220><221>misc _ failure<222>57<223>n ═ a, c, g, or t<400>69agcgcccaac cgttcagacc agcggtttct ctgaggatgc aaagtccatg atgggtnagg 60tcactgagct gtccgaaacc acc atg aat gat ctt gca gct gaa ggt gaa aac 113

Met Asn Asp Leu Ala Ala Glu Gly Glu Asn

1 5 10gat cct tac cgc atg gtt cag cag ctg cgc cgc aag ctc tct cgc ttc 161Asp Pro Tyr Arg Met Val Gln Gln Leu Arg Arg Lys Leu Ser Arg Phe

15 20 25gtc gag cag aag tgg aag cgc cag ccg gtc atc atg cca acc gtc att 209Val Glu Gln Lys Trp Lys Arg Gln Pro Val Ile Met Pro Thr Val Ile

30 35 40ccg atg act gcg gaa acc acg cac atc ggt gac gat gag gtt cgc gct 257Pro Met Thr Ala Glu Thr Thr His Ile Gly Asp Asp Glu Val Arg Ala

45 50 55tca cgc gag tcc ctg taaaagcatt tcgcttttcg acg 295Ser Arg Glu Ser Leu

60<210>70<211>63<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>70Met Asn Asp Leu Ala Ala Glu Gly Glu Asn Asp Pro Tyr Arg Met Val 151015 Gln Gln Leu Arg Arg Lys Leu Ser Arg Phe Val Glu Gln Lys Trp Lys

20 25 30Arg Gln Pro Val Ile Met Pro Thr Val Ile Pro Met Thr Ala Glu Thr

35 40 45Thr His Ile Gly Asp Asp Glu Val Arg Ala Ser Arg Glu Ser Leu

505560<210>7l<211>4653<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (4630)<223>RXN00367<400>71atcgaaagta acccttttgt tacttgcgtt gcaggtagtg tccctgattt tcttattatc 60gaacgattga tagaaacagg attaaagtga ggtatcccgc atg aaa cca caa gga 115

Met Lys Pro Gln Gly

1 5ctc tac aac cct gcg cat gaa cat gac gcc tgc ggt gtg gcg ttt att 163Leu Tyr Asn Pro Ala His Glu His Asp Ala Cys Gly Val Ala Phe Ile

10 15 20gcg gat atc cac ggt cga ccc agc cgc agc att gtt gat cgt gca ctt 211Ala Asp Ile His Gly Arg Pro Ser Arg Ser Ile Val Asp Arg Ala Leu

25 30 35gag gcg ctt cgc aac att gac cac cga ggt gcc gcc ggt gca gag aag 259Glu Ala Leu Arg Asn Ile Asp His Arg Gly Ala Ala Gly Ala Glu Lys

40 45 50aac act ggc gat ggt gcg ggc atc ctc atg cag att ccg gac ggc ttt 307Asn Thr Gly Asp Gly Ala Gly Ile Leu Met Gln Ile Pro Asp Gly Phe

55 60 65tat cgt gaa gta tct ggc att gag ctt cct gag gca ggg gag tat gcc 355Tyr Arg Glu Val Ser Gly Ile Glu Leu Pro Glu Ala Gly Glu Tyr Ala70 75 80 85act ggt att gcg ttc ttg cct cgc ggt cgc atg gcg atg atg gat gct 403Thr Gly Ile Ala Phe Leu Pro Arg Gly Arg Met Ala Met Met Asp Ala

90 95 100cag aag gaa att gag cgc atc gca aag caa gaa ggt gcc gat gtg ctt 451Gln Lys Glu Ile Glu Arg Ile Ala Lys Gln Glu Gly Ala Asp Val Leu

105 110 115ggt tgg cgc atg gtt cct ttt gat tct cgt gat ttg ggt tcc atg gct 499Gly Trp Arg Met Val Pro Phe Asp Ser Arg Asp Leu Gly Ser Met Ala

120 125 130gag gag gcg atg cct agt ttc gcg cag att ttc ctt act gtg cct gga 547Glu Glu Ala Met Pro Ser Phe Ala Gln Ile Phe Leu Thr Val Pro Gly

135 140 145aaa tct ggt gaa gat ctt gac cgt gtg atg ttc ttt atc cgt aag cgt 595Lys Ser Gly Glu Asp Leu Asp Arg Val Met Phe Phe Ile Arg Lys Arg150 155 160 165tgt gag cgt gag ctg ggc acc acc aat ggt cgc gat acg gtg tat ttc 643Cys Glu Arg Glu Leu Gly Thr Thr Asn Gly Arg Asp Thr Val Tyr Phe

170 175 180ccg tcg cta tct tca cgc acc atc att tac aaa ggc atg ttg acc act 691Pro Ser Leu Ser Ser Arg Thr Ile Ile Tyr Lys Gly Met Leu Thr Thr

185 190 195ctg cag ctt gag ggc ttc ttt gag gat ctg ggt gat gct cgc ctg gag 739Leu Gln Leu Glu Gly Phe Phe Glu Asp Leu Gly Asp Ala Arg Leu Glu

200 205 210tcg gcc att gct att gtg cac tcg cgt ttc tcc acg aac act ttc cca 787Ser Ala Ile Ala Ile Val His Ser Arg Phe Ser Thr Asn Thr Phe Pro

215 220 225agc tgg ccg ctg gcg cac ccg tac cgt ttc gtt gcc cac aac ggt gag 835Ser Trp Pro Leu Ala His Pro Tyr Arg Phe Val Ala His Asn Gly Glu230 235 240 245atc aac act gtg cgt ggc aat gaa aac tgg atg cgc gcc cgc gag gcg 883Ile Asn Thr Val Arg Gly Asn Glu Asn Trp Met Arg Ala Arg Glu Ala

250 255 260ctt atc aaa aac gac aag ctg ggc aat ttg agc agc gtg ctg cct atc 931Leu Ile Lys Asn Asp Lys Leu Gly Asn Leu Ser Ser Val Leu Pro Ile

265 270 275tgc acc ccg gag ggc tcg gat acc gcg cgt ttc gac gag gct ttg gag 979Cys Thr Pro Glu Gly Ser Asp Thr Ala Arg Phe Asp Glu Ala Leu Glu

280 285 290ctt ttg cac ctg ggc gga tac tca ctt ccg cat gct gtt gcg atg atg 1027Leu Leu His Leu Gly Gly Tyr Ser Leu Pro His Ala Val Ala Met Met

295 300 305atc cct cag gcg tgg gaa cac aac aag acg ctg agc cct gag ctg cgt 1075Ile Pro Gln Ala Trp Glu His Asn Lys Thr Leu Ser Pro Glu Leu Arg310 315 320 325gat ttc tac gaa tac cac tct tgt ctg atg gag cca tgg gat ggt cct 1123Asp Phe Tyr Glu Tyr His Ser Cys Leu Met Glu Pro Trp Asp Gly Pro

330 335 340gca gcg ctg gca ttt act gac ggt cgt ttt gtg ggt gcc gtg ctg gac 1171Ala Ala Leu Ala Phe Thr Asp Gly Arg Phe Val Gly Ala Val Leu Asp

345 350 355cgt aat ggc ctg cga cct ggg cga atc acc att act gat tcg ggt ttg 1219Arg Asn Gly Leu Arg Pro Gly Arg Ile Thr Ile Thr Asp Ser Gly Leu

360 365 370gtt gtg atg gct tct gaa tcg gga gtg ttg gac ttg agg gag gag agc 1267Val Val Met Ala Ser Glu Ser Gly Val Leu Asp Leu Arg Glu Glu Ser

375 380 385gtc gta aag cgt act cgc gta cag cct gga cgc atg ttc ctt gtt gac 1315Val Val Lys Arg Thr Arg Val Gln Pro Gly Arg Met Phe Leu Val Asp390 395 400 405act gcc gag ggc cgc atc gtt gaa gac gag gaa atc aag cag aaa tta 1363Thr Ala Glu Gly Arg Ile Val Glu Asp Glu Glu Ile Lys Gln Lys Leu

410 415 420agc gaa gcg cag cca tat ggt gag tgg att cgc gat aat ttt gtg cat 1411Ser Glu Ala Gln Pro Tyr Gly Glu Trp Ile Arg Asp Asn Phe Val His

425 430 435ctg gat cgt ctg cct cag aca cgc tac aac tac atg gcg cac tct cgt 1459Leu Asp Arg Leu Pro Gln Thr Arg Tyr Asn Tyr Met Ala His Ser Arg

440 445 450gct gtg ttg cgt cag cgt gtt ttc gga atc act gaa gaa gat gtg gat 1507Ala Val Leu Arg Gln Arg Val PheGly Ile Thr Glu Glu Asp Val Asp

455 460 465ttg ttg ctg ctg ccg atg gcc cgc cag ggt gct gag gcg att ggt tcc 1555Leu Leu Leu Leu Pro Met Ala Arg Gln Gly Ala Glu Ala Ile Gly Ser470 475 480 485atg ggt tcg gat acg cca att gcg gcg cta tcc cag cga cca cgc atg 1603Met Gly Ser Asp Thr Pro Ile Ala Ala Leu Ser Gln Arg Pro Arg Met

490 495 500ctt tat gat ttc ttc gcg cag cgc ttt gct cag gtg aca aac cca ccg 1651Leu Tyr Asp Phe Phe Ala Gln Arg Phe Ala Gln Val Thr Asn Pro Pro

505 510 515ttg gac tct atc cgc gaa aag cct gtg acc agc atg ttc act ttg ttg 1699Leu Asp Ser Ile Arg Glu Lys Pro Val Thr Ser Met Phe Thr Leu Leu

520 525 530ggt gcg cag tct gac gtg ctc aat ccg ggt cct gat gcg gcg cga cgt 1747Gly Ala Gln Ser Asp Val Leu Asn Pro Gly Pro Asp Ala Ala Arg Arg

535 540 545atc cgt ttg gaa tcg ccg atc att gat aac cat gag ctg gcc acc ttg 1795Ile Arg Leu Glu Ser Pro Ile Ile Asp Asn His Glu Leu Ala Thr Leu550 555 560 565atc aat gcc aac gcg cat ggt gag tgg gat tcc ttt ggt gct gct gta 1843Ile Asn Ala Asn Ala His Gly Glu Trp Asp Ser Phe Gly Ala Ala Val

570 575 580att tct ggt ttg tac cca gtg gct cac cat ggt gcc ggc atg aag gct 1891Ile Ser Gly Leu Tyr Pro Val Ala His His Gly Ala Gly Met Lys Ala

585 590 595gcg att gct cgt gtg cgc cgc gag gtt tct gaa gca atc cgc aat ggc 1939Ala Ile Ala Arg Val Arg Arg Glu Val Ser Glu Ala Ile Arg Asn Gly

600 605610aag acg ttg atc gtg ctg tcg gat cgt gaa tct gat gag cgc atg gca 1987Lys Thr Leu Ile Val Leu Ser Asp Arg Glu Ser Asp Glu Arg Met Ala

615 620 625cct atc cct gcg ctg ctg ctg act tcc gct gtg cat cag tac ttg gtg 2035Pro Ile Pro Ala Leu Leu Leu Thr Ser Ala Val His Gln Tyr Leu Val630 635 640 645cag caa cgt acc cgt acc cag tgc tcc ctg gtg gtg gaa tcc ggc gat 2083Gln Gln Arg Thr Arg Thr Gln Cys Ser Leu Val Val Glu Ser Gly Asp

650 655 660gcc cgc gag gtt cat cac ctg gcg atg ctc att ggt ttt ggt gcc gat 2131Ala Arg Glu Val His His Leu Ala Met Leu Ile Gly Phe Gly Ala Asp

665 670 675gcg atc aac ccg tac atg gca ttt gaa acc atc gat gag ctg cgc atg 2179Ala Ile Asn Pro Tyr Met Ala Phe Glu Thr Ile Asp Glu Leu Arg Met

680 685 690aag ggt cag ttg ggt gat ctt tct ttg gat gag gca tcc cga aac tac 2227Lys Gly Gln Leu Gly Asp Leu Ser Leu Asp Glu Ala Ser Arg Asn Tyr

695 700 705atc aag gca gcc acc act ggt gtg ctg aag gtg atg tcc aag atg ggc 2275Ile Lys Ala Ala Thr Thr Gly Val Leu Lys Val Met Ser Lys Met Gly710 715 720 725att gca acg gtg tct tcg tac cgt ggc gcg cag ctt gcc gat gtc act 2323Ile Ala Thr Val Ser Ser Tyr Arg Gly Ala Gln Leu Ala Asp Val Thr

730 735 740ggt ctg cac cag gat ctc ctg gac aac tac ttc ggt ggt att gct tca 2371Gly Leu His Gln Asp Leu Leu Asp Asn Tyr Phe Gly Gly Ile Ala Ser

745 750 755cca att tct ggc atc ggt ctg gat gaa gtt gca gct gac gta gaa gct 2419Pro Ile Ser Gly Ile Gly Leu Asp Glu Val Ala Ala Asp Val Glu Ala

760 765 770cgt cac cgc agc gca ttt ttg cca cgc cct gaa gag cac gct cac cgt 2467Arg His Arg Ser Ala Phe Leu Pro Arg Pro Glu Glu His Ala His Arg

775 780 785gaa ttg gat ttg ggt ggt gaa tac aag tgg cgc cgc gaa ggt gaa tac 2515Glu Leu Asp Leu Gly Gly Glu Tyr Lys Trp Arg Arg Glu Gly Glu Tyr790 795 800 805cac ctg ttc aac cca gaa acc atc ttc aag ctg cag cat gca acg cgt 2563His Leu Phe Asn Pro Glu Thr Ile Phe Lys Leu Gln His Ala Thr Arg

810 815 820tct ggc agc tac gag att ttc aag gat tac acc cgc aag gtt gat gat 2611Ser Gly Ser Tyr Glu Ile Phe Lys Asp Tyr Thr Arg Lys Val Asp Asp

825 830 835caa tcc act cgc ttg ggt act att cgt gga ctg ttt gag ttc agc acg 2659Gln Ser Thr Arg Leu Gly Thr Ile Arg Gly Leu Phe Glu Phe Ser Thr

840 845 850gac cgc aag cca att tcg gtg tct gag gtg gag ccg gtc agt gag atc 2707Asp Arg Lys Pro Ile Ser Val Ser Glu Val Glu Pro Val Ser Glu Ile

855 860 865gtg aag cgt ttc tcc act ggt gcg atg tct tat ggc tcg att tct gct 2755Val Lys Arg Phe Ser Thr Gly Ala Met Ser Tyr Gly Ser Ile Ser Ala870 875 880 885gaa gcc cat gag gtc ttg gcc atc gcc atg aac cga ctg ggc ggt atg 2803Glu Ala His Glu Val Leu Ala Ile Ala Met Asn Arg Leu Gly Gly Met

890 895 900tcc aac tcc ggc gaa ggt ggc gag gac gcc cgc cga ttt gat gtg gaa 2851Ser Asn Ser Gly Glu Gly Gly Glu Asp Ala Arg Arg Phe Asp Val Glu

905 910915ccc aac ggt gac tgg aag cgc tct gcc att aag cag gtg gcc tcg gga 2899Pro Asn Gly Asp Trp Lys Arg Ser Ala Ile Lys Gln Val Ala Ser Gly

920 925 930cgt ttc ggc gtg acc agc cac tac ttg aac aac tgc acc gat att cag 2947Arg Phe Gly Val Thr Ser His Tyr Leu Asn Asn Cys Thr Asp Ile Gln

935 940 945atc aag atg gca cag ggc gca aag ccc ggt gaa ggt ggc cag ctg cca 2995Ile Lys Met Ala Gln Gly Ala Lys Pro Gly Glu Gly Gly Gln Leu Pro950 955 960 965cca aac aag gtg tac cca tgg gtt gca gaa gtc cgc atc acc acc cca 3043Pro Asn Lys Val Tyr Pro Trp Val Ala Glu Val Arg Ile Thr Thr Pro

970 975 980ggc gtt ggt ctg att tcc cct cca cca cac cac gat att tac tcc att 3091Gly Val Gly Leu Ile Ser Pro Pro Pro His His Asp Ile Tyr Ser Ile

985 990 995gag gat ctg gct cag ctg atc cac gac ctg aag aac gct aac cca cgc 3139Glu Asp Leu Ala Gln Leu Ile His Asp Leu Lys Asn Ala Asn Pro Arg

1000 1005 1010gca cga atc cac gtg aag cta gtg gca gaa caa ggc gtg ggc acc gtt 3187Ala Arg Ile His Val Lys Leu Val Ala Glu Gln Gly Val Gly Thr Val

1015 1020 1025gcc gca ggt gtg tcc aaa gca cac gct gat gtg gtg ctt att tcc ggc 3235Ala Ala Gly Val Ser Lys Ala His Ala Asp Val Val Leu Ile Ser Gly1030 1035 1040 1045cac gat ggc gga act ggc gca tct cct ttg acc tcc ctg aag cat gcc 3283His Asp Gly Gly Thr Gly Ala Ser Pro Leu Thr Ser Leu Lys His Ala

1050 1055 1060ggt ggt cca tgg gag ttg ggc ttg gct gaa acc cag caa acg ttg ctg 3331Gly Gly Pro Trp GluLeu Gly Leu Ala Glu Thr Gln Gln Thr Leu Leu

1065 1070 1075ctc aac ggc ctg cgc gat cgt att cgc gtg cag tgc gat ggt cag ctg 3379Leu Asn Gly Leu Arg Asp Arg Ile Arg Val Gln Cys Asp Gly Gln Leu

1080 1085 1090aaa act ggc cga gac gtg gtt atc gca gct ctt ctc ggt gcc gaa gaa 3427Lys Thr Gly Arg Asp Val Val Ile Ala Ala Leu Leu Gly Ala Glu Glu

1095 1100 1105ttc ggt ttt gcc acc gca ccg ctg gtg gtt gaa ggc tgc atc atg atg 3475Phe Gly Phe Ala Thr Ala Pro Leu Val Val Glu Gly Cys Ile Met Met1110 1115 1120 1125cgc gtc tgc cac ctg gac acc tgc ccg gtg ggt atc gct acc cag aac 3523Arg Val Cys His Leu Asp Thr Cys Pro Val Gly Ile Ala Thr Gln Asn

1130 1135 1140ccg gat ttg cgt tcc aag ttc acc ggc aag gct gaa cac gtg gtc aac 3571Pro Asp Leu Arg Ser Lys Phe Thr Gly Lys Ala Glu His Val Val Asn

1145 1150 1155ttc ttc acc ttc atc gcc cag gaa gtc cgt gag tac ttg gca cag ctt 3619Phe Phe Thr Phe Ile Ala Gln Glu Val Arg Glu Tyr Leu Ala Gln Leu

1160 1165 1170ggt ttc cgc tct att gat gaa gcc gtc gga caa gcc cag gtg ctg cgc 3667Gly Phe Arg Ser Ile Asp Glu Ala Val Gly Gln Ala Gln Val Leu Arg

1175 1180 1185aag cgt tcc gga atc cca gct gat tcc cgc gca gca cac ctg gat ttg 3715Lys Arg Ser Gly Ile Pro Ala Asp Ser Arg Ala Ala His Leu Asp Leu1190 1195 1200 1205agc cca att ttc cat cgc cca gaa act cca cac ttc cca act cag gat 3763Ser Pro Ile Phe His Arg Pro Glu Thr Pro His Phe Pro Thr Gln Asp

12101215 1220gtg cgt tgc acc aag acc cag gaa cac agc cta gaa aaa gcc ctg gac 3811Val Arg Cys Thr Lys Thr Gln Glu His Ser Leu Glu Lys Ala Leu Asp

1225 1230 1235aac gca ttt att gat aag gct tcg gac acg atc acc cgt gcc gca gcg 3859Asn Ala Phe Ile Asp Lys Ala Ser Asp Thr Ile Thr Arg Ala Ala Ala

1240 1245 1250ggt gtg gaa acc agc att gtt att gat agc tcc atc agc aac gtc aac 3907Gly Val Glu Thr Ser Ile Val Ile Asp Ser Ser Ile Ser Asn Val Asn

1255 1260 1265cgt tca gtt ggc acg atg ctg ggt tct gca gtc agc cgc gtg gct ggt 3955Arg Ser Val Gly Thr Met Leu Gly Ser Ala Val Ser Arg Val Ala Gly1270 1275 1280 1285gcc caa ggt ttg cca gac ggc acc atc acc ttg aat ctt caa ggc tgc 4003Ala Gln Gly Leu Pro Asp Gly Thr Ile Thr Leu Asn Leu Gln Gly Cys

1290 1295 1300gcc ggt aac tcc ttt ggc gcg ttc atc cca cga ggc atc acc atc aac 4051Ala Gly Asn Ser Phe Gly Ala Phe Ile Pro Arg Gly Ile Thr Ile Asn

1305 1310 1315ctc acc ggc gat gcc aat gac ttt gtg ggc aag gga tta tct ggc gga 4099Leu Thr Gly Asp Ala Asn Asp Phe Val Gly Lys Gly Leu Ser Gly Gly

1320 1325 1330aag att gtg atc aag cct tcc gct cag gct ccg aag cag ctg aag aac 4147Lys Ile Val Ile Lys Pro Ser Ala Gln Ala Pro Lys Gln Leu Lys Asn

1335 1340 1345aat cca aat atc att gcc gga aac gtg ctt gga tac ggc gca acc agt 4195Asn Pro Asn Ile Ile Ala Gly Asn Val Leu Gly Tyr Gly Ala Thr Ser1350 1355 1360 1365ggt gaa ttg ttc att cgt ggc cag gtc ggc gaa cgt ttc tgc gtc cgt 4243Gly Glu Leu Phe Ile Arg Gly Gln Val Gly Glu Arg Phe Cys Val Arg

1370 1375 1380aac tct ggc gcc acc gca gtg gtt gaa ggt atc gga aac cac ggt tgt 4291Asn Ser Gly Ala Thr Ala Val Val Glu Gly Ile Gly Asn His Gly Cys

1385 1390 1395gag tac atg act ggc ggc cga gtc ctg gtt ttg ggc ccg gtt ggt gag 4339Glu Tyr Met Thr Gly Gly Arg Val Leu Val Leu Gly Pro Val Gly Glu

1400 1405 1410aac ttt ggt gcc ggc atg tct ggt ggc att gca tac ctg gct aat tcc 4387Asn Phe Gly Ala Gly Met Ser Gly Gly Ile Ala Tyr Leu Ala Asn Ser

1415 1420 1425ccg gac cta aac cag aag atc aat ggc gaa ttg gtg gat gtt gtt cca 4435Pro Asp Leu Asn Gln Lys Ile Asn Gly Glu Leu Val Asp Val Val Pro1430 1435 1440 1445ctg agc gct gac gat ctg acg tgg gct gat gag ctc att gct cgc cac 4483Leu Ser Ala Asp Asp Leu Thr Trp Ala Asp Glu Leu Ile Ala Arg His

1450 1455 1460cgc gaa ctc acc gga tcc gag acc aag ctg cgt gca caa gat ttg gtg 4531Arg Glu Leu Thr Gly Ser Glu Thr Lys Leu Arg Ala Gln Asp Leu Val

1465 1470 1475aaa atc atg ccg cgc gat ttc caa aaa gta ctc aac atc atc gaa acg 4579Lys Ile Met Pro Arg Asp Phe Gln Lys Val Leu Asn Ile Ile Glu Thr

1480 1485 1490gcc cac gct gag ggc caa gac cca gca atc aag atc atg gag gca gtg 4627Ala His Ala Glu Gly Gln Asp Pro Ala Ile Lys Ile Met Glu Ala Val

149515001505 agc taatggccga cccacaagga ttc 4653Ser1510<210>72<211>1510<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>72Met Lys Pro Gln Gly Leu TyrAsn Pro Ala His Glu His Asp Ala Cys 151015 Gly Val Ala Phe Ile Ala Asp Ile His Gly Arg Pro Ser Arg Ser Ile

20 25 30Val Asp Arg Ala Leu Glu Ala Leu Arg Asn Ile Asp His Arg Gly Ala

35 40 45Ala Gly Ala Glu Lys Asn Thr Gly Asp Gly Ala Gly Ile Leu Met Gln

50 55 60Ile Pro Asp Gly Phe Tyr Arg Glu Val Ser Gly Ile Glu Leu Pro Glu 65 70 75 80Ala Gly Glu Tyr Ala Thr Gly Ile Ala Phe Leu Pro Arg Gly Arg Met

85 90 95Ala Met Met Asp Ala Gln Lys Glu Ile Glu Arg Ile Ala Lys Gln Glu

100 105 110Gly Ala Asp Val Leu Gly Trp Arg Met Val Pro Phe Asp Ser Arg Asp

115 120 125Leu Gly Ser Met Ala Glu Glu Ala Met Pro Ser Phe Ala Gln Ile Phe

130 135 140Leu Thr Val Pro Gly Lys Ser Gly Glu Asp Leu Asp Arg Val Met Phe145 150 155 160Phe Ile Arg Lys Arg Cys Glu Arg Glu Leu Gly Thr Thr Asn Gly Arg

165 170 175Asp Thr Val Tyr Phe Pro Ser Leu Ser Ser Arg Thr Ile Ile Tyr Lys

180 185 190Gly Met Leu Thr Thr Leu Gln Leu Glu Gly Phe Phe Glu Asp Leu Gly

195 200 205Asp Ala Arg Leu Glu Ser Ala Ile Ala Ile Val His Ser Arg Phe Ser

210 215 220Thr Asn Thr Phe Pro Ser Trp Pro Leu Ala His Pro Tyr Arg Phe Val225 230 235 240Ala His Asn Gly Glu Ile Asn Thr Val Arg Gly Asn Glu Asn Trp Met

245 250 255Arg Ala Arg Glu Ala Leu Ile Lys Asn Asp Lys Leu Gly Asn Leu Ser

260 265 270Ser Val Leu Pro Ile Cys Thr Pro Glu Gly Ser Asp Thr Ala Arg Phe

275 280 285Asp Glu Ala Leu Glu Leu Leu His Leu Gly Gly Tyr Ser Leu Pro His

290 295 300Ala Val Ala Met Met Ile Pro Gln Ala Trp Glu His Asn Lys Thr Leu305 310 315 320Ser Pro Glu Leu Arg Asp Phe Tyr Glu Tyr His Ser Cys Leu Met Glu

325 330 335Pro Trp Asp Gly Pro Ala Ala Leu Ala Phe Thr Asp Gly Arg Phe Val

340 345 350Gly Ala Val Leu Asp Arg Asn Gly Leu Arg Pro Gly Arg Ile Thr Ile

355 360 365Thr Asp Ser Gly Leu Val Val Met Ala Ser Glu Ser Gly Val Leu Asp

370 375 380Leu Arg Glu Glu Ser Val Val Lys Arg Thr Arg Val Gln Pro Gly Arg385 390 395 400Met Phe Leu Val Asp Thr Ala Glu Gly Arg Ile Val Glu Asp Glu Glu

405 410 415Ile Lys Gln Lys Leu Ser Glu Ala Gln Pro Tyr Gly Glu Trp Ile Arg

420 425 430Asp Asn Phe Val His Leu Asp Arg Leu Pro Gin Thr Arg Tyr Asn Tyr

435 440 445Met Ala His Ser Arg Ala Val Leu Arg Gln Arg Val Phe Gly Ile Thr

450455 460Glu Glu Asp Val Asp Leu Leu Leu Leu Pro Met Ala Arg Gln Gly Ala465 470 475 480Glu Ala Ile Gly Ser Met Gly Ser Asp Thr Pro Ile Ala Ala Leu Ser

485 490 495Gln Arg Pro Arg Met Leu Tyr Asp Phe Phe Ala Gln Arg Phe Ala Gln

500 505 510Val Thr Asn Pro Pro Leu Asp Ser Ile Arg Glu Lys Pro Val Thr Ser

515 520 525Met Phe Thr Leu Leu Gly Ala Gln Ser Asp Val Leu Asn Pro Gly Pro

530 535 540Asp Ala Ala Arg Arg Ile Arg Leu Glu Ser Pro Ile Ile Asp Asn His545 550 555 560Glu Leu Ala Thr Leu Ile Asn Ala Asn Ala His Gly Glu Trp Asp Ser

565 570 575Phe Gly Ala Ala Val Ile Ser Gly Leu Tyr Pro Val Ala His His Gly

580 585 590Ala Gly Met Lys Ala Ala Ile Ala Arg Val Arg Arg Glu Val Ser Glu

595 600 605Ala Ile Arg Asn Gly Lys Thr Leu Ile Val Leu Ser Asp Arg Glu Ser

610 615 620Asp Glu Arg Met Ala Pro Ile Pro Ala Leu Leu Leu Thr Ser Ala Val625 630 635 640His Gln Tyr Leu Val Gln Gln Arg Thr Arg Thr Gln Cys Ser Leu Val

645 650 655Val Glu Ser Gly Asp Ala Arg Glu Val His His Leu Ala Met Leu Ile

660 665 670Gly Phe Gly Ala Asp Ala Ile Asn Pro Tyr Met Ala Phe Glu Thr Ile

675680 685Asp Glu Leu Arg Met Lys Gly Gln Leu Gly Asp Leu Ser Leu Asp Glu

690 695 700Ala Ser Arg Asn Tyr Ile Lys Ala Ala Thr Thr Gly Val Leu Lys Val705 710 715 720Met Ser Lys Met Gly Ile Ala Thr Val Ser Ser Tyr Arg Gly Ala Gln

725 730 735Leu Ala Asp Val Thr Gly Leu His Gln Asp Leu Leu Asp Asn Tyr Phe

740 745 750Gly Gly Ile Ala Ser Pro Ile Ser Gly Ile Gly Leu Asp Glu Val Ala

755 760 765Ala Asp Val Glu Ala Arg His Arg Ser Ala Phe Leu Pro Arg Pro Glu

770 775 780Glu His Ala His Arg Glu Leu Asp Leu Gly Gly Glu Tyr Lys Trp Arg785 790 795 800Arg Glu Gly Glu Tyr His Leu Phe Asn Pro Glu Thr Ile Phe Lys Leu

805 810 815Gln His Ala Thr Arg Ser Gly Ser Tyr Glu Ile Phe Lys Asp Tyr Thr

820 825 830Arg Lys Val Asp Asp Gln Ser Thr Arg Leu Gly Thr Ile Arg Gly Leu

835 840 845Phe Glu Phe Ser Thr Asp Arg Lys Pro Ile Ser Val Ser Glu Val Glu

850 855 860Pro Val Ser Glu Ile Val Lys Arg Phe Ser Thr Gly Ala Met Ser Tyr865 870 875 880Gly Ser Ile Ser Ala Glu Ala His Glu Val Leu Ala Ile Ala Met Asn

885 890 895Arg Leu Gly Gly Met Ser Asn Ser Gly Glu Gly Gly Glu Asp Ala Arg

900 905910Arg Phe Asp Val Glu Pro Asn Gly Asp Trp Lys Arg Ser Ala Ile Lys

915 920 925Gln Val Ala Ser Gly Arg Phe Gly Val Thr Ser His Tyr Leu Asn Asn

930 935 940Cys Thr Asp Ile Gln Ile Lys Met Ala Gln Gly Ala Lys Pro Gly Glu945 950 955 960Gly Gly Gln Leu Pro Pro Asn Lys Val Tyr Pro Trp Val Ala Glu Val

965 970 975Arg Ile Thr Thr Pro Gly Val Gly Leu Ile Ser Pro Pro Pro His His

980 985 990Asp Ile Tyr Ser Ile Glu Asp Leu Ala Gln Leu Ile His Asp Leu Lys

995 1000 1005Asn Ala Asn Pro Arg Ala Arg Ile His Val Lys Leu Val Ala Glu Gln

1010 1015 1020Gly Val Gly Thr Val Ala Ala Gly Val Ser Lys Ala His Ala Asp Val1025 1030 1035 1040Val Leu Ile Ser Gly His Asp Gly Gly Thr Gly Ala Ser Pro Leu Thr

1045 1050 1055Ser Leu Lys His Ala Gly Gly Pro Trp Glu Leu Gly Leu Ala Glu Thr

1060 1065 1070Gln Gln Thr Leu Leu Leu Asn Gly Leu Arg Asp Arg Ile Arg Val Gln

1075 1080 1085Cys Asp Gly Gln Leu Lys Thr Gly Arg Asp Val Val Ile Ala Ala Leu

1090 1095 1100Leu Gly Ala Glu Glu Phe Gly Phe Ala Thr Ala Pro Leu Val Val Glu1105 1110 1115 1120Gly Cys Ile Met Met Arg Val Cys His Leu Asp Thr Cys Pro Val Gly

1125 1130 1135Ile Ala Thr Gln Asn Pro Asp Leu Arg Ser Lys Phe Thr Gly Lys Ala

1140 1145 1150Glu His Val Val Asn Phe Phe Thr Phe Ile Ala Gln Glu Val Arg Glu

1155 1160 1165Tyr Leu Ala Gln Leu Gly Phe Arg Ser Ile Asp Glu Ala Val Gly Gln

1170 1175 1180Ala Gln Val Leu Arg Lys Arg Ser Gly Ile Pro Ala Asp Ser Arg Ala1185 1190 1195 1200Ala His Leu Asp Leu Ser Pro Ile Phe His Arg Pro Glu Thr Pro His

1205 1210 1215Phe Pro Thr Gln Asp Val Arg Cys Thr Lys Thr Gln Glu His Ser Leu

1220 1225 1230Glu Lys Ala Leu Asp Asn Ala Phe Ile Asp Lys Ala Ser Asp Thr Ile

1235 1240 1245Thr Arg Ala Ala Ala Gly Val Glu Thr Ser Ile Val Ile Asp Ser Ser

1250 1255 1260Ile Ser Asn Val Asn Arg Ser Val Gly Thr Met Leu Gly Ser Ala Val1265 1270 1275 1280Ser Arg Val Ala Gly Ala Gln Gly Leu Pro Asp Gly Thr Ile Thr Leu

1285 1290 1295Asn Leu Gln Gly Cys Ala Gly Asn Ser Phe Gly Ala Phe Ile Pro Arg

1300 1305 1310Gly Ile Thr Ile Asn Leu Thr Gly Asp Ala Asn Asp Phe Val Gly Lys

1315 1320 1325Gly Leu Ser Gly Gly Lys Ile Val Ile Lys Pro Ser Ala Gln Ala Pro

1330 1335 1340Lys Gln Leu Lys Asn Asn Pro Asn Ile Ile Ala Gly Asn Val Leu Gly1345 1350 1355 1360TyrGly Ala Thr Ser Gly Glu Leu Phe Ile Arg Gly Gln Val Gly Glu

1365 1370 1375Arg Phe Cys Val Arg Asn Ser Gly Ala Thr Ala Val Val Glu Gly Ile

1380 1385 1390Gly Asn His Gly Cys Glu Tyr Met Thr Gly Gly Arg Val Leu Val Leu

1395 1400 1405Gly Pro Val Gly Glu Asn Phe Gly Ala Gly Met Ser Gly Gly Ile Ala

1410 1415 1420Tyr Leu Ala Asn Ser Pro Asp Leu Asn Gln Lys Ile Asn Gly Glu Leu1425 1430 1435 1440Val Asp Val Val Pro Leu Ser Ala Asp Asp Leu Thr Trp Ala Asp Glu

1445 1450 1455Leu Ile Ala Arg His Arg Glu Leu Thr Gly Ser Glu Thr Lys Leu Arg

1460 1465 1470Ala Gln Asp Leu Val Lys Ile Met Pro Arg Asp Phe Gln Lys Val Leu

1475 1480 1485Asn Ile Ile Glu Thr Ala His Ala Glu Gly Gln Asp Pro Ala Ile Lys

149014951500 Ile Met Glu Ala Val Ser 15051510<210>73<211>1906<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1906)<223>FRXA00007<400>73atcgaaagta acccttttgt tacttgcgtt gcaggtagtg tccctgattt tcttattatc 60gaacgattga tagaaacagg attaaagtga ggtatcccgc atg aaa cca caa gga 115

Met Lys Pro Gln Gly

1 5ctc tac aac cct gcg cat gaa cat gac gcc tgc ggt gtg gcg ttt att 163Leu Tyr Asn Pro Ala His Glu His Asp Ala Cys Gly Val Ala Phe Ile

l0 15 20gcg gat atc cac ggt cga ccc agc cgc agc att gtt gat cgt gca ctt 211Ala Asp Ile His Gly Arg Pro Ser Arg Ser Ile Val Asp Arg Ala Leu

25 30 35gag gcg ctt cgc aac att gac cac cga ggt gcc gcc ggt gca gag aag 259Glu Ala Leu Arg Asn Ile Asp His Arg Gly Ala Ala Gly Ala Glu Lys

40 45 50aac act ggc gat ggt gcg ggc atc ctc atg cag att ccg gac ggc ttt 307Asn Thr Gly Asp Gly Ala Gly Ile Leu Met Gln Ile Pro Asp Gly Phe

55 60 65tat cgt gaa gta tct ggc att gag ctt cct gag gca ggg gag tat gcc 355Tyr Arg Glu Val Ser Gly Ile Glu Leu Pro Glu Ala Gly Glu Tyr Ala 70 75 80 85act ggt att gcg ttc ttg cct cgc ggt cgc atg gcg atg atg gat gct 403Thr Gly Ile Ala Phe Leu Pro Arg Gly Arg Met Ala Met Met Asp Ala

90 95 100cag aag gaa att gag cgc atc gca aag caa gaa ggt gcc gat gtg ctt 451Gln Lys Glu Ile Glu Arg Ile Ala Lys Gln Glu Gly Ala Asp Val Leu

105 110 115ggt tgg cgc atg gtt cct ttt gat tct cgt gat ttg ggt tcc atg gct 499Gly Trp Arg Met Val Pro Phe Asp Ser Arg Asp Leu Gly Ser Met Ala

120 125 130gag gag gcg atg cct agt ttc gcg cag att ttc ctt act gtg cct gga 547Glu Glu Ala Met Pro Ser Phe Ala Gln Ile Phe Leu Thr Val Pro Gly

135 140 145aaa tct ggt gaa gat ctt gac cgt gtg atg ttc ttt atc cgt aag cgt 595Lys Ser Gly Glu Asp Leu Asp Arg Val Met Phe Phe Ile Arg Lys Arg150 155 160 165tgt gag cgt gag ctg ggc acc acc aat ggt cgc gat acg gtg tat ttc 643CysGlu Arg Glu Leu Gly Thr Thr Asn Gly Arg Asp Thr Val Tyr Phe

170 175 180ccg tcg cta tct tca cgc acc atc att tac aaa ggc atg ttg acc act 691Pro Ser Leu Ser Ser Arg Thr Ile Ile Tyr Lys Gly Met Leu Thr Thr

185 190 195ctg cag ctt gag ggc ttc ttt gag gat ctg ggt gat gct cgc ctg gag 739Leu Gln Leu Glu Gly Phe Phe Glu Asp Leu Gly Asp Ala Arg Leu Glu

200 205 210tcg gcc att gct att gtg cac tcg cgt ttc tcc acg aac act ttc cca 787Ser Ala Ile Ala Ile Val His Ser Arg Phe Ser Thr Asn Thr Phe Pro

215 220 225agc tgg ccg ctg gcg cac ccg tac cgt ttc gtt gcc cac aac ggt gag 835Ser Trp Pro Leu Ala His Pro Tyr Arg Phe Val Ala His Asn Gly Glu230 235 240 245atc aac act gtg cgt ggc aat gaa aac tgg atg cgc gcc cgc gag gcg 883Ile Asn Thr Val Arg Gly Asn Glu Asn Trp Met Arg Ala Arg Glu Ala

250 255 260ctt atc aaa aac gac aag ctg ggc aat ttg agc agc gtg ctg cct atc 931Leu Ile Lys Asn Asp Lys Leu Gly Asn Leu Ser Ser Val Leu Pro Ile

265 270 275tgc acc ccg gag ggc tcg gat acc gcg cgt ttc gac gag gct ttg gag 979Cys Thr Pro Glu Gly Ser Asp Thr Ala Arg Phe Asp Glu Ala Leu Glu

280 285 290ctt ttg cac ctg ggc gga tac tca ctt ccg cat gct gtt gcg atg atg 1027Leu Leu His Leu Gly Gly Tyr Ser Leu Pro His Ala Val Ala Met Met

295 300 305atc cct cag gcg tgg gaa cac aac aag acg ctg agc cct gag ctg cgt 1075Ile Pro Gln Ala Trp Glu His Asn Lys Thr Leu Ser Pro Glu Leu Arg310 315320 325gat ttc tac gaa tac cac tct tgt ctg atg gag cca tgg gat ggt cct 1123Asp Phe Tyr Glu Tyr His Ser Cys Leu Met Glu Pro Trp Asp Gly Pro

330 335 340gca gcg ctg gca ttt act gac ggt cgt ttt gtg ggt gcc gtg ctg gac 1171Ala Ala Leu Ala Phe Thr Asp Gly Arg Phe Val Gly Ala Val Leu Asp

345 350 355cgt aat ggc ctg cga cct ggg cga atc acc att act gat tcg ggt ttg 1219Arg Asn Gly Leu Arg Pro Gly Arg Ile Thr Ile Thr Asp Ser Gly Leu

360 365 370gtt gtg atg gct tct gaa tcg gga gtg ttg gac ttg agg gag gag agc 1267Val Val Met Ala Ser Glu Ser Gly Val Leu Asp Leu Arg Glu Glu Ser

375 380 385gtc gta aag cgt act cgc gta cag cct gga cgc atg ttc ctt gtt gac 1315Val Val Lys Arg Thr Arg Val Gln Pro Gly Arg Met Phe Leu Val Asp390 395 400 405act gcc gag ggc cgc atc gtt gaa gac gag gaa atc aag cag aaa tta 1363Thr Ala Glu Gly Arg Ile Val Glu Asp Glu Glu Ile Lys Gln Lys Leu

410 415 420agc gaa gcg cag cca tat ggt gag tgg att cgc gat aat ttt gtg cat 1411Ser Glu Ala Gln Pro Tyr Gly Glu Trp Ile Arg Asp Asn Phe Val His

425 430 435ctg gat cgt ctg cct cag aca cgc tac aac tac atg gcg cac tct cgt 1459Leu Asp Arg Leu Pro Gln Thr Arg Tyr Asn Tyr Met Ala His Ser Arg

440 445 450gct gtg ttg cgt cag cgt gtt ttc gga atc act gaa gaa gat gtg gat 1507Ala Val Leu Arg Gln Arg Val Phe Gly Ile Thr Glu Glu Asp Val Asp

455 460 465ttg ttg ctg ctg ccg atg gcc cgc cag ggt gct gag gcg att ggt tcc 1555Leu Leu Leu Leu Pro Met Ala Arg Gln Gly Ala Glu Ala Ile Gly Ser470 475 480 485atg ggt tcg gat acg cca att gcg gcg cta tcc cag cga cca cgc atg 1603Met Gly Ser Asp Thr Pro Ile Ala Ala Leu Ser Gln Arg Pro Arg Met

490 495 500ctt tat gat ttc ttc gcg cag cgc ttt gct cag gtg aca aac cca ccg 1651Leu Tyr Asp Phe Phe Ala Gln Arg Phe Ala Gln Val Thr Asn Pro Pro

505 510 515ttg gac tct atc cgc gaa aag cct gtg acc agc atg ttc act ttg ttg 1699Leu Asp Ser Ile Arg Glu Lys Pro Val Thr Ser Met Phe Thr Leu Leu

520 525 530ggt gcg cag tct gac gtg ctc aat ccg ggt cct gat gcg gcg cga cgt 1747Gly Ala Gln Ser Asp Val Leu Asn Pro Gly Pro Asp Ala Ala Arg Arg

535 540 545att cgt ttg gaa tcg ccg atc att gat aac cat gag ctg gcc acc ttg 1795Ile Arg Leu Glu Ser Pro Ile Ile Asp Asn His Glu Leu Ala Thr Leu550 555 560 565atc aat gcc aac gcg cat ggt gag tgg gat tcc ttt ggt gct gct gta 1843Ile Asn Ala Asn Ala His Gly Glu Trp Asp Ser Phe Gly Ala Ala Val

570 575 580att tct ggt ttg tac cca gtg gct cac cat ggt gcc ggc atg aag gct 1891Ile Ser Gly Leu Tyr Pro Val Ala His His Gly Ala Gly Met Lys Ala

585 590 595gcg att gct cgt gtg 1906Ala Ile Ala Arg Val

600<210>74<211>602<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>74Met Lys Pro Gln Gly Leu Tyr Asn Pro Ala His Glu His Asp Ala Cys 151015 Gly Val Ala Phe Ile Ala Asp Ile His Gly Arg Pro Ser Arg Ser Ile

20 25 30Val Asp Arg Ala Leu Glu Ala Leu Arg Asn Ile Asp His Arg Gly Ala

35 40 45Ala Gly Ala Glu Lys Asn Thr Gly Asp Gly Ala Gly Ile Leu Met Gln

50 55 60Ile Pro Asp Gly Phe Tyr Arg Glu Val Ser Gly Ile Glu Leu Pro Glu 65 70 75 80Ala Gly Glu Tyr Ala Thr Gly Ile Ala Phe Leu Pro Arg Gly Arg Met

85 90 95Ala Met Met Asp Ala Gln Lys Glu Ile Glu Arg Ile Ala Lys Gln Glu

100 105 110Gly Ala Asp Val Leu Gly Trp Arg Met Val Pro Phe Asp Ser Arg Asp

115 120 125Leu Gly Ser Met Ala Glu Glu Ala Met Pro Ser Phe Ala Gln Ile Phe

130 135 140Leu Thr Val Pro Gly Lys Ser Gly Glu Asp Leu Asp Arg Val Met Phe145 150 155 160Phe Ile Arg Lys Arg Cys Glu Arg Glu Leu Gly Thr Thr Asn Gly Arg

165 170 175Asp Thr Val Tyr Phe Pro Ser Leu Ser Ser Arg Thr Ile Ile Tyr Lys

180 185 190Gly Met Leu Thr Thr Leu Gln Leu Glu Gly Phe Phe Glu Asp Leu Gly

195 200 205Asp Ala Arg Leu Glu Ser Ala Ile Ala Ile Val His Ser Arg Phe Ser

210 215 220Thr Asn Thr Phe Pro Ser Trp Pro Leu Ala His Pro Tyr Arg Phe Val225 230 235 240Ala His Asn Gly Glu Ile Asn Thr Val Arg Gly Asn Glu Asn Trp Met

245 250 255Arg Ala Arg Glu Ala Leu Ile Lys Asn Asp Lys Leu Gly Asn Leu Ser

260 265 270Ser Val Leu Pro Ile Cys Thr Pro Glu Gly Ser Asp Thr Ala Arg Phe

275 280 285Asp Glu Ala Leu Glu Leu Leu His Leu Gly Gly Tyr Ser Leu Pro His

290 295 300Ala Val Ala Met Met Ile Pro Gln Ala Trp Glu His Asn Lys Thr Leu305 310 315 320Ser Pro Glu Leu Arg Asp Phe Tyr Glu Tyr His Ser Cys Leu Met Glu

325 330 335Pro Trp Asp Gly Pro Ala Ala Leu Ala Phe Thr Asp Gly Arg Phe Val

340 345 350Gly Ala Val Leu Asp Arg Asn Gly Leu Arg Pro Gly Arg Ile Thr Ile

355 360 365Thr Asp Ser Gly Leu Val Val Met Ala Ser Glu Ser Gly Val Leu Asp

370 375 380Leu Arg Glu Glu Ser Val Val Lys Arg Thr Arg Val Gln Pro Gly Arg385 390 395 400Met Phe Leu Val Asp Thr Ala Glu Gly Arg Ile Val Glu Asp Glu Glu

405 410 415Ile Lys Gln Lys Leu Ser Glu Ala Gln Pro Tyr Gly Glu Trp Ile Arg

420 425 430Asp Asn Phe Val His Leu Asp Arg Leu Pro Gln Thr Arg Tyr Asn Tyr

435 440 445Met Ala His Ser Arg Ala Val Leu Arg Gln Arg Val Phe Gly Ile Thr

450 455 460Glu Glu Asp Val Asp Leu Leu Leu Leu Pro Met Ala Arg Gln Gly Ala465470 475 480Glu Ala Ile Gly Ser Met Gly Ser Asp Thr Pro Ile Ala Ala Leu Ser

485 490 495Gln Arg Pro Arg Met Leu Tyr Asp Phe Phe Ala Gln Arg Phe Ala Gln

500 505 510Val Thr Asn Pro Pro Leu Asp Ser Ile Arg Glu Lys Pro Val Thr Ser

515 520 525Met Phe Thr Leu Leu Gly Ala Gln Ser Asp Val Leu Asn Pro Gly Pro

530 535 540Asp Ala Ala Arg Arg Ile Arg Leu Glu Ser Pro Ile Ile Asp Asn His545 550 555 560Glu Leu Ala Thr Leu Ile Asn Ala Asn Ala His Gly Glu Trp Asp Ser

565 570 575Phe Gly Ala Ala Val Ile Ser Gly Leu Tyr Pro Val Ala His His Gly

580 585 590Ala Gly Met Lys Ala Ala Ile Ala Arg Val

595600<210>75<211>1362<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(70). (1362)<223>FRXA00364<400>75accaatttct ggcatcggtc tggatgaagt tgcagctgac gtagaaagct cgtcaccgca 60gcgcatttt ttg cca cgc cct gaa gag cac gct cac cgt gaa ttg gat ttg 111

Leu Pro Arg Pro Glu Glu His Ala His Arg Glu Leu Asp Leu

1 5 10ggt ggt gaa tac aag tgg cgc cgc gaa ggt gaa tac cac ctg ttc aac 159Gly Gly Glu Tyr Lys Trp Arg Arg Glu Gly Glu Tyr His Leu Phe Asn 15 20 25 30cca gaa acc atc ttc aag ctg cag cat gca acg cgt tct ggc agc tac 207Pro Glu Thr Ile Phe Lys Leu Gln His Ala Thr Arg Ser Gly Ser Tyr

35 40 45gag att ttc aag gat tac acc cgc aag gtt gat gat caa tcc act cgc 255Glu Ile Phe Lys Asp Tyr Thr Arg Lys Val Asp Asp Gln Ser Thr Arg

50 55 60ttg ggt act att cgt gga ctg ttt gag ttc agc acg gac cgc aag cca 303Leu Gly Thr Ile Arg Gly Leu Phe Glu Phe Ser Thr Asp Arg Lys Pro

65 70 75att tcg gtg tct gag gtg gag ccg gtc agt gag atc gtg aag cgt ttc 351Ile Ser Val Ser Glu Val Glu Pro Val Ser Glu Ile Val Lys Arg Phe

80 85 90tcc act ggt gcg atg tct tat ggc tcg att tct gct gaa gcc cat gag 399Ser Thr Gly Ala Met Ser Tyr Gly Ser Ile Ser Ala Glu Ala His Glu 95 100 105 110gtc ttg gcc atc gcc atg aac cga ctg ggc ggt atg tcc aac tcc ggc 447Val Leu Ala Ile Ala Met Asn Arg Leu Gly Gly Met Ser Asn Ser Gly

115 120 125gaa ggt ggc gag gac gcc cgc cga ttt gat gtg gaa ccc aac ggt gac 495Glu Gly Gly Glu Asp Ala Arg Arg Phe Asp Val Glu Pro Asn Gly Asp

130 135 140tgg aag cgc tct gcc att aag cag gtg gcc tcg gga cgt ttc ggc gtg 543Trp Lys Arg Ser Ala Ile Lys Gln Val Ala Ser Gly Arg Phe Gly Val

145 150 155acc agc cac tac ttg aac aac tgc acc gat att cag atc aag atg gca 591Thr Ser His Tyr Leu Asn Asn Cys Thr Asp Ile Gln Ile Lys Met Ala

160 165 170cag ggc gca aag ccc ggt gaa ggt ggc cag ctg cca cca aac aag gtg 639Gln Gly Ala Lys Pro Gly Glu Gly Gly Gln Leu Pro Pro Asn Lys Val175 180 185 190tac cca tgg gtt gca gaa gtc cgc atc acc acc cca ggc gtt ggt ctg 687Tyr Pro Trp Val Ala Glu Val Arg Ile Thr Thr Pro Gly Val Gly Leu

195 200 205att tcc cct cca cca cac cac gat att tac tcc att gag gat ctg gct 735Ile Ser Pro Pro Pro His His Asp Ile Tyr Ser Ile Glu Asp Leu Ala

210 215 220cag ctg atc cac gac ctg aag aac gct aac cca cgc gca cga atc cac 783Gln Leu Ile His Asp Leu Lys Asn Ala Asn Pro Arg Ala Arg Ile His

225 230 235gtg aag cta gtg gca gaa caa ggc gtg ggc acc gtt gcc gca ggt gtg 831Val Lys Leu Val Ala Glu Gln Gly Val Gly Thr Val Ala Ala Gly Val

240 245 250tcc aaa gca cac gct gat gtg gtg ctt att tcc ggc cac gat ggc gga 879Ser Lys Ala His Ala Asp Val Val Leu Ile Ser Gly His Asp Gly Gly255 260 265 270act ggc gca tct cct ttg acc tcc ctg aag cat gcc ggt ggt cca tgg 927Thr Gly Ala Ser Pro Leu Thr Ser Leu Lys His Ala Gly Gly Pro Trp

275 280 285gag ttg ggc ttg gct gaa acc cag caa acg ttg ctg ctc aac ggc ctg 975Glu Leu Gly Leu Ala Glu Thr Gln Gln Thr Leu Leu Leu Asn Gly Leu

290 295 300cgc gat cgt att cgc gtg cag tgc gat ggt cag ctg aaa act ggc cga 1023Arg Asp Arg Ile Arg Val Gln Cys Asp Gly Gln Leu Lys Thr Gly Arg

305 310 315gac gtg gtt atc gca gct ctt ctc ggt gcc gaa gaa ttc ggt ttt gcc 1071Asp Val Val Ile Ala Ala Leu Leu Gly Ala Glu Glu Phe Gly Phe Ala

320 325 330acc gca ccg ctg gtg gtt gaa ggc tgc atc atg atg cgc gtc tgc cac 1119Thr Ala Pro Leu Val Val Glu Gly Cys Ile Met Met Arg Val Cys His335340 345 350ctg gac acc tgc ccg gtg ggt atc gct acc cag aac ccg gat ttg cgt 1167Leu Asp Thr Cys Pro Val Gly Ile Ala Thr Gln Asn Pro Asp Leu Arg

355 360 365tcc aag ttc acc ggc aag gct gaa cac gtg gtc aac ttc ttc acc ttc 1215Ser Lys Phe Thr Gly Lys Ala Glu His Val Val Asn Phe Phe Thr Phe

370 375 380atc gcc cag gaa gtc cgt gag tac ttg gca cag ctt ggt ttc cgc tct 1263Ile Ala Gln Glu Val Arg Glu Tyr Leu Ala Gln Leu Gly Phe Arg Ser

385 390 395att gat gaa gcc gtc gga caa gcc cag gtg ctg cgc aag cgt tcc gga 1311Ile Asp Glu Ala Val Gly Gln Ala Gln Val Leu Arg Lys Arg Ser Gly

400405410 atc cca gct gat tcc cgc gca gca cac ctg gat ttg agc cca att ttc 1359Ile Pro Ala Asp Ser Arg Ala Ala His Leu Asp Leu Ser Pro Ile Phe 415420425430 atc 1362Ile<210>76<211>431<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>76Leu Pro Arg Pro Glu Glu His Ala His Arg Glu Leu Asp Leu Gly Gly 151015 Glu Tyr Lys Trp Arg Arg Glu Gly Glu Tyr His Leu Phe Asn Pro Glu

20 25 30Thr Ile Phe Lys Leu Gln His Ala Thr Arg Ser Gly Ser Tyr Glu Ile

35 40 45Phe Lys Asp Tyr Thr Arg Lys Val Asp Asp Gln Ser Thr Arg Leu Gly

50 55 60Thr Ile Arg Gly Leu Phe Glu Phe Ser Thr Asp Arg Lys Pro Ile Ser 65 70 75 80Val Ser Glu Val Glu Pro Val Ser Glu Ile Val Lys Arg Phe Ser Thr

85 90 95Gly Ala Met Ser Tyr Gly Ser Ile Ser Ala Glu Ala His Glu ValLeu

100 105 110Ala Ile Ala Met Asn Arg Leu Gly Gly Met Ser Asn Ser Gly Glu Gly

115 120 125Gly Glu Asp Ala Arg Arg Phe Asp Val Glu Pro Asn Gly Asp Trp Lys

130 135 140Arg Ser Ala Ile Lys Gln Val Ala Ser Gly Arg Phe Gly Val Thr Ser145 150 155 160His Tyr Leu Asn Asn Cys Thr Asp Ile Gln Ile Lys Met Ala Gln Gly

165 170 175Ala Lys Pro Gly Glu Gly Gly Gln Leu Pro Pro Asn Lys Val Tyr Pro

180 185 190Trp Val Ala Glu Val Arg Ile Thr Thr Pro Gly Val Gly Leu Ile Ser

195 200 205Pro Pro Pro His His Asp Ile Tyr Ser Ile Glu Asp Leu Ala Gln Leu

210 215 220Ile His Asp Leu Lys Asn Ala Asn Pro Arg Ala Arg Ile His Val Lys225 230 235 240Leu Val Ala Glu Gln Gly Val Gly Thr Val Ala Ala Gly Val Ser Lys

245 250 255Ala His Ala Asp Val Val Leu Ile Ser Gly His Asp Gly Gly Thr Gly

260 265 270Ala Ser Pro Leu Thr Ser Leu Lys His Ala Gly Gly Pro Trp Glu Leu

275 280 285Gly Leu Ala Glu Thr Gln Gln Thr Leu Leu Leu Asn Gly Leu Arg Asp

290 295 300Arg Ile Arg Val Gln Cys Asp Gly Gln Leu Lys Thr Gly Arg Asp Val305 310 315 320Val Ile Ala Ala Leu Leu Gly Ala Glu Glu Phe Gly Phe Ala Thr Ala

325 330 335Pro Leu Val Val Glu Gly Cys Ile Met Met Arg Val Cys His Leu Asp

340 345 350Thr Cys Pro Val Gly Ile Ala Thr Gln Asn Pro Asp Leu Arg Ser Lys

355 360 365Phe Thr Gly Lys Ala Glu His Val Val Asn Phe Phe Thr Phe Ile Ala

370 375 380Gln Glu Val Arg Glu Tyr Leu Ala Gln Leu Gly Phe Arg Ser Ile Asp385 390 395 400Glu Ala Val Gly Gln Ala Gln Val Leu Arg Lys Arg Ser Gly Ile Pro

405 410 415Ala Asp Ser Arg Ala Ala His Leu Asp Leu Ser Pro Ile Phe Ile

420425430<210>77<211>866<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) } (843)<223>FRXA00367<400>77cac agc cta gaa aaa gcc ctg gac aac gca ttt att gat aag gct tcg 48His Ser Leu Glu Lys Ala Leu Asp Asn Ala Phe Ile Asp Lys Ala Ser15 l 015 gac acg atc acc cgt gcc gca gcg ggt gtg gaa acc agc att gtt att 96Asp Thr Ile Thr Arg Ala Ala Ala Gly Val Glu Thr Ser Ile Val Ile

20 25 30gat agc tcc atc agc aac gtc aac cgt tca gtt ggc acg atg ctg ggt 144Asp Ser Ser Ile Ser Asn Val Asn Arg Ser Val Gly Thr Met Leu Gly

35 40 45tct gca gtc agc cgc gtg gct ggt gcc caa ggt ttg cca gac ggc acc 192Ser Ala Val Ser Arg Val Ala Gly Ala Gln Gly Leu Pro Asp Gly Thr

50 55 60atc acc ttg aat ctt caa ggc tgc gcc ggt aac tcc ttt ggc gcg ttc 240Ile Thr Leu Asn Leu Gln Gly Cys Ala Gly Asn Ser Phe Gly Ala Phe 65 70 75 80atc cca cga ggc atc acc atc aac ctc acc ggc gat gcc aat gac ttt 288Ile Pro Arg Gly Ile Thr Ile Asn Leu Thr Gly Asp Ala Asn Asp Phe

85 90 95gtg ggc aag gga tta tct ggc gga aag att gtg atc aag cct tcc gct 336Val Gly Lys Gly Leu Ser Gly Gly Lys Ile Val Ile Lys Pro Ser Ala

100 105 110cag gct ccg aag cag ctg aag aac aat cca aat atc att gcc gga aac 384Gln Ala Pro Lys Gln Leu Lys Asn Asn Pro Asn Ile Ile Ala Gly Asn

115 120 125gtg ctt gga tac ggc gca acc agt ggt gaa ttg ttc att cgt ggc cag 432Val Leu Gly Tyr Gly Ala Thr Ser Gly Glu Leu Phe Ile Arg Gly Gln

130 135 140gtc ggc gaa cgt ttc tgc gtc cgt aac tct ggc gcc acc gca gtg gtt 480Val Gly Glu Arg Phe Cys Val Arg Asn Ser Gly Ala Thr Ala Val Val145 150 155 160gaa ggt atc gga aac cac ggt tgt gag tac atg act ggc ggc cga gtc 528Glu Gly Ile Gly Asn His Gly Cys Glu Tyr Met Thr Gly Gly Arg Val

165 170 175ctg gtt ttg ggc ccg gtt ggt gag aac ttt ggt gcc ggc atg tct ggt 576Leu Val Leu Gly Pro Val Gly Glu Asn Phe Gly Ala Gly Met Ser Gly

180 185 190ggc att gca tac ctg gct aat tcc ccg gac cta aac cag aag atc aat 624Gly Ile Ala Tyr Leu Ala Asn Ser Pro Asp Leu Asn Gln Lys Ile Asn

195 200 205ggc gaa ttg gtg gat gtt gtt cca ctg agc gct gac gat ctg acg tgg 672Gly Glu Leu Val Asp Val Val Pro Leu Ser Ala Asp Asp Leu Thr Trp

210 215 220gct gat gag ctc att gct cgc cac cgc gaactc acc gga tcc gag acc 720Ala Asp Glu Leu Ile Ala Arg His Arg Glu Leu Thr Gly Ser Glu Thr225 230 235 240aag ctg cgt gca caa gat ttg gtg aaa atc atg ccg cgc gat ttc caa 768Lys Leu Arg Ala Gln Asp Leu Val Lys Ile Met Pro Arg Asp Phe Gln

245 250 255aaa gta ctc aac atc atc gaa acg gcc cac gct gag ggc caa gac cca 816Lys Val Leu Asn Ile Ile Glu Thr Ala His Ala Glu Gly Gln Asp Pro

260 265 270gca atc aag atc atg gag gca gtg agc taatggccga cccacaagga 863Ala Ile Lys Ile Met Glu Ala Val Ser

275280 ttc 866<210>78<211>281<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>78His Ser Leu Glu Lys Ala Leu Asp Asn Ala Phe Ile Asp Lys Ala Ser 151015 Asp Thr Ile Thr Arg Ala Ala Ala Gly Val Glu Thr Ser Ile Val Ile

20 25 30Asp Ser Ser Ile Ser Asn Val Asn Arg Ser Val Gly Thr Met Leu Gly

35 40 45Ser Ala Val Ser Arg Val Ala Gly Ala Gln Gly Leu Pro Asp Gly Thr

50 55 60Ile Thr Leu Asn Leu Gln Gly Cys Ala Gly Asn Ser Phe Gly Ala Phe 65 70 75 80Ile Pro Arg Gly Ile Thr Ile Asn Leu Thr Gly Asp Ala Asn Asp Phe

85 90 95Val Gly Lys Gly Leu Ser Gly Gly Lys Ile Val Ile Lys Pro Ser Ala

100 105 110Gln Ala Pro Lys Gln Leu Lys Asn Asn Pro Asn Ile Ile Ala Gly Asn

115 120 125Val Leu Gly Tyr Gly Ala Thr Ser Gly Glu Leu Phe Ile Arg Gly Gln

130 135 140Val Gly Glu Arg Phe Cys Val Arg Asn Ser Gly Ala Thr Ala Val Val145 150 155 160Glu Gly Ile Gly Asn His Gly Cys Glu Tyr Met Thr Gly Gly Arg Val

165 170 175Leu Val Leu Gly Pro Val Gly Glu Asn Phe Gly Ala Gly Met Ser Gly

180 185 190Gly Ile Ala Tyr Leu Ala Asn Ser Pro Asp Leu Asn Gln Lys Ile Asn

195 200 205Gly Glu Leu Val Asp Val Val Pro Leu Ser Ala Asp Asp Leu Thr Trp

210 215 220Ala Asp Glu Leu Ile Ala Arg His Arg Glu Leu Thr Gly Ser Glu Thr225 230 235 240Lys Leu Arg Ala Gln Asp Leu Val Lys Ile Met Pro Arg Asp Phe Gln

245 250 255Lys Val Leu Asn Ile Ile Glu Thr Ala His Ala Glu Gly Gln Asp Pro

260 265 270Ala Ile Lys Ile Met Glu Ala Val Ser

275280<210>79<211>1494<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1471)<223>RXN00076<400>79tctaggagtg ttaaacagcc tggacttgaa acacctttaa ctacttgatt ttcacaccct 60tgtttccata aaagggctca cgaaaggcaa cttcaaacac atg aca act ccc ctg 115

Met Thr Thr Pro Leu

1 5cgc gta gcc gtc atc gga gct ggc cct gct ggc att tac gca tcc gac 163Arg Val Ala Val Ile Gly Ala Gly Pro Ala Gly Ile Tyr Ala Ser Asp

10 15 20ctc ctc atc cgc aat gaa gag cgc gaa gtg ttc gtt gac ctt ttc gag 211Leu Leu Ile Arg Asn Glu Glu Arg Glu Val Phe Val Asp Leu Phe Glu

25 30 35caa atg cct gca ccg ttc gga ctc atc cgt tac ggc gtt gct cca gac 259Gln Met Pro Ala Pro Phe Gly Leu Ile Arg Tyr Gly Val Ala Pro Asp

40 45 50cac cca cgc atc aag ggc atc gtt aag tcc ctg cac aac gtg ttg gac 307His Pro Arg Ile Lys Gly Ile Val Lys Ser Leu His Asn Val Leu Asp

55 60 65aag cca cgc ctg cgc ctg ctc ggt aac att gaa atc ggc aaa gac atc 355Lys Pro Arg Leu Arg Leu Leu Gly Asn Ile Glu Ile Gly Lys Asp Ile 70 75 80 85acc gtc gaa gaa ctc cgc gac tac tac gat gca gtc gtg ttc tcc acc 403Thr Val Glu Glu Leu Arg Asp Tyr Tyr Asp Ala Val Val Phe Ser Thr

90 95 100ggc gca gtt gca gac cgc gac ctc aac atc ccc gga att gaa gca gaa 451Gly Ala Val Ala Asp Arg Asp Leu Asn Ile Pro Gly Ile Glu Ala Glu

105 110 115ggc tcc ttc ggt gcc ggc gag ttc gtt ggc ttc tac gac ggc aac cca 499Gly Ser Phe Gly Ala Gly Glu Phe Val Gly Phe Tyr Asp Gly Asn Pro

120 125 130cgc ttc gag cgc tcc tgg gat ctg tct gca cag tcc gtc gct gtt atc 547Arg Phe Glu Arg Ser Trp Asp Leu Ser Ala Gln Ser Val Ala Val Ile

135 140 145ggc gtt ggt aac gtc ggc ctc gac gta gcc cgc atc ctg gct aag aca 595Gly Val Gly Asn Val Gly Leu Asp Val Ala Arg Ile Leu Ala Lys Thr150 155 160 165ggc gac gag ctc aaa gtc acc gaa att tcc gac aac gtc tac gac tcc 643Gly Asp Glu Leu Lys Val Thr Glu Ile Ser Asp Asn Val Tyr Asp Ser

170 175 180ctc aaa gaa aac aag gcc act gaa gtg cac gtt ttc gga cgt cgt ggc 691Leu Lys Glu Asn Lys Ala Thr Glu Val His Val Phe Gly Arg Arg Gly

185 190 195cca gca cag gtc aag ttc acc cca cag gaa ctc aaa gaa ctc gac cac 739Pro Ala Gln Val Lys Phe Thr Pro Gln Glu Leu Lys Glu Leu Asp His

200 205 210tcc ccc acc atc aac gtg gtt gtt gat cca gaa gac atc gac tac gac 787Ser Pro Thr Ile Asn Val Val Val Asp Pro Glu Asp Ile Asp Tyr Asp

215 220 225ggc gcc tct gaa gaa gcc cgc cgc gca tcc aag tcc cag gac ctg gtc 835Gly Ala Ser Glu Glu Ala Arg Arg Ala Ser Lys Ser Gln Asp Leu Val230 235 240 245tgc cag atc ctg gaa cag tac gca atc cgc gag cca aag gac gct ccg 883Cys Gln Ile Leu Glu Gln Tyr Ala Ile Arg Glu Pro Lys Asp Ala Pro

250 255 260cac acc ctg cag atc cac ctc ttt gaa aac cca gtt gag gtt ctt caa 931His Thr Leu Gln Ile His Leu Phe Glu Asn Pro Val Glu Val Leu Gln

265 270 275aag gac ggc aag gtt gtt ggc ctg cgc acc gaa cgc acc tca ctt gat 979Lys Asp Gly Lys Val Val Gly Leu Arg Thr Glu Arg Thr Ser Leu Asp

280 285 290ggc aac ggc ggc gta aac gga acc ggc gaa ttc aag gac tgg cca gtc 1027Gly Asn Gly Gly Val Asn Gly Thr Gly Glu Phe Lys Asp Trp Pro Val

295 300 305cag gct gtc tac cgc gca gtc ggc tac aag tcc gac ccc atc gac ggc 1075Gln Ala Val Tyr Arg Ala Val Gly Tyr Lys Ser Asp Pro Ile Asp Gly310 315 320325gtc cca ttc gat gag aac aag cac gtc atc cct aat gac ggc gga cat 1123Val Pro Phe Asp Glu Asn Lys His Val Ile Pro Asn Asp Gly Gly His

330 335 340gtc ctc acc gct cca ggc gca gaa cca gta cca ggc ctc tat gca acc 1171Val Leu Thr Ala Pro Gly Ala Glu Pro Val Pro Gly Leu Tyr Ala Thr

345 350 355ggc tgg atc aag cgt gga cca atc ggt cta atc ggc aac acc aag tcc 1219Gly Trp Ile Lys Arg Gly Pro Ile Gly Leu Ile Gly Asn Thr Lys Ser

360 365 370gac gcc aag gaa acc acc gac atc ctc atc aag gat gcc gtc gcc ggt 1267Asp Ala Lys Glu Thr Thr Asp Ile Leu Ile Lys Asp Ala Val Ala Gly

375 380 385gta ctt gaa gct cca aag cac cag ggc gaa gaa gcc atc atc gag ctt 1315Val Leu Glu Ala Pro Lys His Gln Gly Glu Glu Ala Ile Ile Glu Leu390 395 400 405ctc gat tcc cgc aac atc cca ttc acc acc tgg gaa ggc tgg tac aaa 1363Leu Asp Ser Arg Asn Ile Pro Phe Thr Thr Trp Glu Gly Trp Tyr Lys

410 415 420ctc gac gca gca gag cgc gca ctc ggt gaa gcc gaa ggc cgc gag cgc 1411Leu Asp Ala Ala Glu Arg Ala Leu Gly Glu Ala Glu Gly Arg Glu Arg

425 430 435aag aag att gtt gat tgg gaa gaa atg gtc cgc cag gcc cgc gaa gct 1459Lys Lys Ile Val Asp Trp Glu Glu Met Val Arg Gln Ala Arg Glu Ala

440 445 450cca gca att gtc taaattgttt taacgcgtga agc 1494Pro Ala Ile Val

455<210>80<21l>457<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>80Met Thr Thr Pro Leu Arg Val Ala Val Ile Gly Ala Gly Pro Ala Gly 151015 Ile Tyr Ala Ser Asp Leu Leu Ile Arg Asn Glu Glu Arg Glu Val Phe

20 25 30Val Asp Leu Phe Glu Gln Met Pro Ala Pro Phe Gly Leu Ile Arg Tyr

35 40 45Gly Val Ala Pro Asp His Pro Arg Ile Lys Gly Ile Val Lys Ser Leu

50 55 60His Asn Val Leu Asp Lys Pro Arg Leu Arg Leu Leu Gly Asn Ile Glu 65 70 75 80Ile Gly Lys Asp Ile Thr Val Glu Glu Leu Arg Asp Tyr Tyr Asp Ala

85 90 95Val Val Phe Ser Thr Gly Ala Val Ala Asp Arg Asp Leu Asn Ile Pro

100 105 110Gly Ile Glu Ala Glu Gly Ser Phe Gly Ala Gly Glu Phe Val Gly Phe

115 120 125Tyr Asp Gly Asn Pro Arg Phe Glu Arg Ser Trp Asp Leu Ser Ala Gln

130 135 140Ser Val Ala Val Ile Gly Val Gly Asn Val Gly Leu Asp Val Ala Arg145 150 155 160Ile Leu Ala Lys Thr Gly Asp Glu Leu Lys Val Thr Glu Ile Ser Asp

165 170 175Asn Val Tyr Asp Ser Leu Lys Glu Asn Lys Ala Thr Glu Val His Val

180 185 190Phe Gly Arg Arg Gly Pro Ala Gln Val Lys Phe Thr Pro Gln Glu Leu

195 200 205Lys Glu Leu Asp His Ser Pro Thr Ile Asn Val Val Val Asp Pro Glu

210 215 220Asp Ile Asp Tyr Asp Gly Ala Ser Glu Glu Ala Arg Arg Ala Ser Lys225 230 235240Ser Gln Asp Leu Val Cys Gln Ile Leu Glu Gln Tyr Ala Ile Arg Glu

245 250 255Pro Lys Asp Ala Pro His Thr Leu Gln Ile His Leu Phe Glu Asn Pro

260 265 270Val Glu Val Leu Gln Lys Asp Gly Lys Val Val Gly Leu Arg Thr Glu

275 280 285Arg Thr Ser Leu Asp Gly Asn Gly Gly ValAsn Gly Thr Gly Glu Phe

290 295 300Lys Asp Trp Pro Val Gln Ala Val Tyr Arg Ala Val Gly Tyr Lys Ser305 310 315 320Asp Pro Ile Asp Gly Val Pro Phe Asp Glu Asn Lys His Val Ile Pro

325 330 335Asn Asp Gly Gly His Val Leu Thr Ala Pro Gly Ala Glu Pro Val Pro

340 345 350Gly Leu Tyr Ala Thr Gly Trp Ile Lys Arg Gly Pro Ile Gly Leu Ile

355 360 365Gly Asn Thr Lys Ser Asp Ala Lys Glu Thr Thr Asp Ile Leu Ile Lys

370 375 380Asp Ala Val Ala Gly Val Leu Glu Ala Pro Lys His Gln Gly Glu Glu385 390 395 400Ala Ile Ile Glu Leu Leu Asp Ser Arg Asn Ile Pro Phe Thr Thr Trp

405 410 415Glu Gly Trp Tyr Lys Leu Asp Ala Ala Glu Arg Ala Leu Gly Glu Ala

420 425 430Glu Gly Arg Glu Arg Lys Lys Ile Val Asp Trp Glu Glu Met Val Arg

435 440 445Gln Ala Arg Glu Ala Pro Ala Ile Val

450455<210>81<211>786<212>DNA<213>corynebacterium glutamicum (corynebacterium glutamicum)<220><221>CDS<222>(101). (763)<223>FRXA00075<220><221>VARIANT<222>187<223>Xaa ═ Val or Ala<220><221>VARIANT<222>188<223>Xaa ═ Thr or Ser<220><221>VARIANT<222>209<223>Xaa ═ Lys or gin<220><221>VARIANT<222>212<223>Xaa ═ Arg<400>81 3860 60tgtttccata aaagggctca cgaaaggcaa cttcaaacac atg aca act ccc ctg 115<222>209<223>Xaa ═ Lys or gin<220><221>VARIANT<212<223>Xaa ═ Arg<400>81tctaggagtg ttaaacagcc tggacttgaa acacctttaa ctacttgatt ttcacaccct 60tgtttccata aaagggctca cgaaaggcaa cttcaaacac atg aca act ccc ctg

Met Thr Thr Pro Leu

1 5cgc gta gcc gtc atc gga gct ggc cct gct ggc att tac gca tcc gac 163Arg Val Ala Val Ile Gly Ala Gly Pro Ala Gly Ile Tyr Ala Ser Asp

10 15 20ctc ctc atc cgc aat gaa gag cgc gaa gtg ttc gtt gac ctt ttc gag 211Leu Leu Ile Arg Asn Glu Glu Arg Glu Val Phe Val Asp Leu Phe Glu

25 30 35caa atg cct gca ccg ttc gga ctc atc cgt tac ggc gtt gct cca gac 259Gln Met Pro Ala Pro Phe Gly Leu Ile Arg Tyr Gly Val Ala Pro Asp

40 45 50cac cca cgc atc aag ggc atc gtt aag tcc ctg cac aac gtg ttg gac 307His Pro Arg Ile Lys Gly Ile Val Lys Ser Leu His Asn Val Leu Asp

55 60 65aag cca cgc ctg cgc ctg ctc ggt aac att gaa atc ggc aaa gac atc 355Lys Pro Arg Leu Arg Leu Leu Gly Asn Ile Glu Ile Gly Lys Asp Ile 7075 80 85acc gtc gaa gaa ctc cgc gac tac tac gat gca gtc gtg ttc tcc acc 403Thr Val Glu Glu Leu Arg Asp Tyr Tyr Asp Ala Val Val Phe Ser Thr

90 95 100ggc gca gtt gca gac cgc gac ctc aac atc ccc gga att gaa gca gaa 451Gly Ala Val Ala Asp Arg Asp Leu Asn Ile Pro Gly Ile Glu Ala Glu

105 110 115ggc tcc ttc ggt gcc ggc gag ttc gtt ggc ttc tac gac ggc aac cca 499Gly Ser Phe Gly Ala Gly Glu Phe Val Gly Phe Tyr Asp Gly Asn Pro

120 125 130cgc ttc gag cgc tcc tgg gat ctg tct gca cag tcc gtc gct gtt atc 547Arg Phe Glu Arg Ser Trp Asp Leu Ser Ala Gln Ser Val Ala Val Ile

135 140 145ggc gtt ggt aac gtc ggc ctc gac gta gcc cgc atc ctg gct aag aca 595Gly Val Gly Asn Val Gly Leu Asp Val Ala Arg Ile Leu Ala Lys Thr150 155 160 165ggc gac gag ctc aaa gtc acc gaa att tcc gac aac gtc tac gac tcc 643Gly Asp Glu Leu Lys Val Thr Glu Ile Ser Asp Asn Val Tyr Asp Ser

170 175 180ctc aaa gaa aac aag gyc wct gaa gtg cac gtt ttc gga cgt cgg tgg 691Leu Lys Glu Asn Lys Xaa Xaa Glu Val His Val Phe Gly Arg Arg Trp

185 190 195ccc agc aca ggt caa gtt cac ccc aca gga act maa aga act cgr cca 739Pro Ser Thr Gly Gln Val His Pro Thr Gly Thr Xaa Arg Thr Xaa Pro

200 205 210ctc ccc cac cat caa cgt ggt tgt tgatccagaa gacatcgact acg 786Leu Pro His His Gln Arg Gly Cys

215220<210>82<211>221<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>VARIANT<222>187<223>Xaa ═ Val or Ala<220><221>VARIANT<222>188<223>Xaa ═ Thr or Ser<220><221>VARIANT<222>209<223>Xaa ═ Lys or Gln<220><221>VARIANT<222>212<223>Xaa ═ Arg<400>82Met Thr Thr Pro Leu Arg Val Ala Val Ile Gly Ala Gly Pro Ala Gly 151015 Ile Tyr Ala Ser Asp Leu Leu Ile Arg Asn Glu Glu Arg Glu Val Phe

20 25 30Val Asp Leu Phe Glu Gln Met Pro Ala Pro Phe Gly Leu Ile Arg Tyr

35 40 45Gly Val Ala Pro Asp His Pro Arg Ile Lys Gly Ile Val Lys Ser Leu

50 55 60His Asn Val Leu Asp Lys Pro Arg Leu Arg Leu Leu Gly Asn Ile Glu 65 70 75 80Ile Gly Lys Asp Ile Thr Val Glu Glu Leu Arg Asp Tyr Tyr Asp Ala

85 90 95Val Val Phe Ser Thr Gly Ala Val Ala Asp Arg Asp Leu Asn Ile Pro

100 105 110Gly Ile Glu Ala Glu Gly Ser Phe Gly Ala Gly Glu Phe Val Gly Phe

115 120 125Tyr Asp Gly Asn Pro Arg Phe Glu Arg Ser Trp Asp Leu Ser Ala Gln

130 135 140Ser Val Ala Val Ile Gly Val Gly Asn Val Gly Leu Asp Val Ala Arg145 150 155 160Ile Leu Ala Lys Thr Gly Asp Glu Leu Lys Val Thr Glu Ile Ser Asp

165 170 175Asn Val Tyr Asp Ser Leu Lys Glu Asn Lys Xaa Xaa Glu Val His Val

180 185 190Phe Gly Arg Arg Trp Pro Ser Thr Gly GlnVal His Pro Thr Gly Thr

195 200 205Xaa Arg Thr Xaa Pro Leu Pro His His Gln Arg Gly Cys

210215220<210>83<211>672<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (649)<223>RXN00198<400>83atgcaggatt agagcagcag caacggagcc agaatcagtc tcccaatttg atatccagcc 60ccgcgctcct ttccagcgcg ccgattccac tccatggccg atg tac ccc aac ctc 115

Met Tyr Pro Asn Leu

1 5ttc cgc acc gca acg gct cac gaa gaa ggc gaa tac atc atc act ggc 163Phe Arg Thr Ala Thr Ala His Glu Glu Gly Glu Tyr Ile Ile Thr Gly

10 15 20gat gaa tca gcc gat gaa atc gca gcc ctg ggc ctc gcc gaa cgt gcc 211Asp Glu Ser Ala Asp Glu Ile Ala Ala Leu Gly Leu Ala Glu Arg Ala

25 30 35gca ggc tcc acg ctt ggt gaa cgt aaa ttt gct gtc aac acc gtg gaa 259Ala Gly Ser Thr Leu Gly Glu Arg Lys Phe Ala Val Asn Thr Val Glu

40 45 50ttc cac ggc aac aac ggc cac gtc acc gga ctc acc ggc aac caa atc 307Phe His Gly Asn Asn Gly His Val Thr Gly Leu Thr Gly Asn Gln Ile

55 60 65cga gtt gtc aac ggc aaa cgt gaa cca atc gaa ggc acc gaa ttc ccc 355Arg Val Val Asn Gly Lys Arg Glu Pro Ile Glu Gly Thr Glu Phe Pro 70 75 80 85ttc gaa gca gac ctc gtt ctt gtt gca ctt ggc ttc acc ggc gca gaa 403Phe Glu Ala Asp Leu Val Leu Val Ala Leu Gly Phe Thr Gly Ala Glu

90 95 100caa ggc gga ttg gca cac gaa cta ggc gta ggt ttc gac gac cgg ggc 451Gln Gly Gly Leu Ala His Glu Leu Gly Val Gly Phe Asp Asp Arg Gly

105 110 115cgc atc ctc cgc gat tcc gaa tac cgc agc ccc acc aac tcc cgc gtt 499Arg Ile Leu Arg Asp Ser Glu Tyr Arg Ser Pro Thr Asn Ser Arg Val

120 125 130tac atc gca ggc gac aac ggc cgt ggc cag tcc ctg atc gtg tgg gca 547Tyr Ile Ala Gly Asp Asn Gly Arg Gly Gln Ser Leu Ile Val Trp Ala

135 140 145atc gcc gaa ggc cgc gca tgc gcc gca gct atc gac gcc gat ctc atg 595Ile Ala Glu Gly Arg Ala Cys Ala Ala Ala Ile Asp Ala Asp Leu Met150 155 160 165ggt gaa act gca ctc cct gta gca gtt gca cca cag gac gtg ccg ctg 643Gly Glu Thr Ala Leu Pro Val Ala Val Ala Pro Gln Asp Val Pro Leu

170175180 gct gtc tagcttgggt agaaaatgct aga 672Ala Val<210>84<211>183<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>84Met Tyr Pro Asn Leu Phe Arg Thr Ala Thr Ala His Glu Glu Gly Glu 151015 Tyr Ile Ile Thr Gly Asp Glu Ser Ala Asp Glu Ile Ala Ala Leu Gly

20 25 30Leu Ala Glu Arg Ala Ala Gly Ser Thr Leu Gly Glu Arg Lys Phe Ala

35 40 45Val Asn Thr Val Glu Phe His Gly Asn Asn Gly His Val Thr Gly Leu

50 55 60Thr Gly Asn Gln Ile Arg Val Val Asn Gly Lys Arg Glu Pro Ile Glu 65 70 75 80Gly Thr Glu Phe Pro Phe Glu Ala Asp Leu Val Leu Val Ala Leu Gly

85 90 95Phe Thr Gly Ala Glu Gln Gly Gly Leu Ala His Glu Leu Gly Val Gly

100 105 110Phe Asp Asp Arg Gly Arg Ile Leu Arg Asp Ser Glu Tyr Arg Ser Pro

115 120 125Thr Asn Ser Arg Val Tyr Ile Ala Gly Asp Asn Gly Arg Gly Gln Ser

130 135 140Leu Ile Val Trp Ala Ile Ala Glu Gly Arg Ala Cys Ala Ala Ala Ile145 150 155 160Asp Ala Asp Leu Met Gly Glu Thr Ala Leu Pro Val Ala Val Ala Pro

165 170 175Gln Asp Val Pro Leu Ala Val

180<210>85<211>305<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (282)<223>FRXA00198<400>85ctc gtt ctt gtt gca ctt ggc ttc acc ggc gca gaa caa ggc gga ttg 48Leu Val Leu Val Ala Leu Gly Phe Thr Gly Ala Glu Gln Gly Gly Leu 151015 gca cac gaa cta ggc gta ggt ttc gac gac cgg ggc cgc atc ctc cgc 96Ala His Glu Leu Gly Val Gly Phe Asp Asp Arg Gly Arg Ile Leu Arg

20 25 30gat tcc gaa tac cgc agc ccc acc aac tcc cgc gtt tac atc gca ggc 144Asp Ser Glu Tyr Arg Ser Pro Thr Asn Ser Arg Val Tyr Ile Ala Gly

35 40 45gac aac ggc cgt ggc cag tcc ctg atc gtg tgg gca atc gcc gaa ggc 192Asp Asn Gly Arg Gly Gln Ser Leu Ile Val Trp Ala Ile Ala Glu Gly

50 55 60cgc gca tgc gcc gca gct atc gac gcc gat ctc atg ggt gaa act gca 240Arg Ala Cys Ala Ala Ala Ile Asp Ala Asp Leu Met Gly Glu Thr Ala 65 70 75 80ctc cct gta gca gtt gca cca cag gac gtg ccg ctg gct gtc 282Leu Pro Val Ala Val Ala Pro Gln Asp Val Pro Leu Ala Val

8590 tagcttgggt agaaaatgct aga 305<210>86<211>94<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>86Leu Val Leu Val Ala Leu Gly Phe Thr Gly Ala Glu Gln Gly Gly Leu l 51015 Ala His Glu Leu Gly Val Gly Phe Asp Asp Arg Gly Arg Ile Leu Arg

20 25 30Asp Ser Glu Tyr Arg Ser Pro Thr Asn Ser Arg Val Tyr Ile Ala Gly

35 40 45Asp Asn Gly Arg Gly Gln Ser Leu Ile Val Trp Ala Ile Ala Glu Gly

50 55 60Arg Ala Cys Ala Ala Ala Ile Asp Ala Asp Leu Met Gly Glu Thr Ala 65 70 75 80Leu Pro Val Ala Val Ala Pro Gln Asp Val Pro Leu Ala Val

8590<210>87<211>727<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (727)<223>RXN00365<400>87gaagcctacg atcgcttgca cgcgaccaac aatttccccg agttcaccgg ccgtttgtgc 60cccgcaccct gcgaaggcgc ctgcgtgctc ggtatcaacg atg att ctg tca cca 115

Met Ile Leu Ser Pro

1 5tca aaa acg ttt gag ctg gaa atc gtc gaa aaa gca ttc cgc gaa ggc 163Ser Lys Thr Phe Glu Leu Glu Ile Val Glu Lys Ala Phe Arg Glu Gly

10 15 20tgg gtg caa cca gta atc cca tcc atg tct acc ggg ctg tca gtc gcc 211Trp Val Gln Pro Val Ile Pro Ser Met Ser Thr Gly Leu Ser Val Ala

25 30 35gtc gtc ggt tcc ggc ccc gct ggc ctt gcc gcc gcg cag cag ctc acc 259Val Val Gly Ser GlyPro Ala Gly Leu Ala Ala Ala Gln Gln Leu Thr

40 45 50cgc gca ggc cac agc gtt acc gtc ttt gaa cgc gac gac cgc ctc ggc 307Arg Ala Gly His Ser Val Thr Val Phe Glu Arg Asp Asp Arg Leu Gly

55 60 65ggc ctc atg cgc tac ggc gtg cca gaa tac aaa atg gag aac cgc tgg 355Gly Leu Met Arg Tyr Gly Val Pro Glu Tyr Lys Met Glu Asn Arg Trp 70 75 80 85atc gac cgc cgc atc gag caa atg gaa gca gag ggc aca act ttc cag 403Ile Asp Arg Arg Ile Glu Gln Met Glu Ala Glu Gly Thr Thr Phe Gln

90 95 100gta ggc acc tcg ccg cgc gcc gct gaa cta gcg ctt ttc gac gcg atc 451Val Gly Thr Ser Pro Arg Ala Ala Glu Leu Ala Leu Phe Asp Ala Ile

105 110 115ctc ctc gca acc ggc acc cca gtg gcc cgc gaa ctc tca gtt cca ggc 499Leu Leu Ala Thr Gly Thr Pro Val Ala Arg Glu Leu Ser Val Pro Gly

120 125 130cac gat ctc aac ggc atc cat gcg gca atg gat tac ctc acc gcc caa 547His Asp Leu Asn Gly Ile His Ala Ala Met Asp Tyr Leu Thr Ala Gln

135 140 145aac cgc atc aac gaa ggc gac ggt gaa gtc tct cca atc aac gcc aaa 595Asn Arg Ile Asn Glu Gly Asp Gly Glu Val Ser Pro Ile Asn Ala Lys150 155 160 165ggc aag aaa gtt gtc atc atc ggt ggc ggc gac acc ggc acc gac tgc 643Gly Lys Lys Val Val Ile Ile Gly Gly Gly Asp Thr Gly Thr Asp Cys

170 175 180ttc ggc acc gca ctg cgc caa gga gca gaa tca gtc acc caa ttt gat 691Phe Gly Thr Ala Leu Arg Gln Gly Ala Glu Ser Val Thr Gln Phe Asp

185 190 195atc cgc ccccgc gct cct ttc cag cgc gcc gat tcc 727Ile Arg Pro Arg Ala Pro Phe Gln Arg Ala Asp Ser

200205<210>88<211>209<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>88Met Ile Leu Ser Pro Ser Lys Thr Phe Glu Leu Glu Ile Val Glu Lys 151015 Ala Phe Arg Glu Gly Trp Val Gln Pro Val Ile Pro Ser Met Ser Thr

20 25 30Gly Leu Ser Val Ala Val Val Gly Ser Gly Pro Ala Gly Leu Ala Ala

35 40 45Ala Gln Gln Leu Thr Arg Ala Gly His Ser Val Thr Val Phe Glu Arg

50 55 60Asp Asp Arg Leu Gly Gly Leu Met Arg Tyr Gly Val Pro Glu Tyr Lys 65 70 75 80Met Glu Asn Arg Trp Ile Asp Arg Arg Ile Glu Gln Met Glu Ala Glu

85 90 95Gly Thr Thr Phe Gln Val Gly Thr Ser Pro Arg Ala Ala Glu Leu Ala

100 105 110Leu Phe Asp Ala Ile Leu Leu Ala Thr Gly Thr Pro Val Ala Arg Glu

115 120 125Leu Ser Val Pro Gly His Asp Leu Asn Gly Ile His Ala Ala Met Asp

130 135 140Tyr Leu Thr Ala Gln Asn Arg Ile Asn Glu Gly Asp Gly Glu Val Ser145 150 155 160Pro Ile Asn Ala Lys Gly Lys Lys Val Val Ile Ile Gly Gly Gly Asp

165 170 175Thr Gly Thr Asp Cys Phe Gly Thr Ala Leu Arg Gln Gly Ala Glu Ser

180 185 190Val Thr Gln Phe Asp Ile Arg Pro Arg Ala Pro Phe Gln Arg Ala Asp

195200205 Ser<210>89<211>727<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (727)<223>FRXA00365<400>89gaagcctacg atcgcttgca cgcgaccaac aatttccccg agttcaccgg ccgtttgtgc 60cccgcaccct gcgaaggcgc ctgcgtgctc ggtatcaacg atg att ctg tca cca 115

Met Ile Leu Ser Pro

1 5tca aaa acg ttt gag ctg gaa atc gtc gaa aaa gca ttc cgc gaa ggc 163Ser Lys Thr Phe Glu Leu Glu Ile Val Glu Lys Ala Phe Arg Glu Gly

10 15 20tgg gtg caa cca gta atc cca tcc atg tct acc ggg ctg tca gtc gcc 211Trp Val Gln Pro Val Ile Pro Ser Met Ser Thr Gly Leu Ser Val Ala

25 30 35gtc gtc ggt tcc ggc ccc gct ggc ctt gcc gcc gcg cag cag ctc acc 259Val Val Gly Ser Gly Pro Ala Gly Leu Ala Ala Ala Gln Gln Leu Thr

40 45 50cgc gca ggc cac agc gtt acc gtc ttt gaa cgc gac gac cgc ctc ggc 307Arg Ala Gly His Ser Val Thr Val Phe Glu Arg Asp Asp Arg Leu Gly

55 60 65ggc ctc atg cgc tac ggc gtg cca gaa tac aaa atg gag aac cgc tgg 355Gly Leu Met Arg Tyr Gly Val Pro Glu Tyr Lys Met Glu Asn Arg Trp70 75 80 85atc gac cgc cgc atc gag caa atg gaa gca gag ggc aca act ttc cag 403Ile Asp Arg Arg Ile Glu Gln Met Glu Ala Glu Gly Thr Thr Phe Gln

90 95 100gta ggc acc tcg ccg cgc gcc gct gaa cta gcg ctt ttc gac gcg atc 451Val Gly Thr Ser Pro Arg Ala Ala Glu Leu Ala Leu Phe Asp Ala Ile

105 110 115ctc ctc gca acc ggc acc cca gtg gcc cgc gaa ctc tca gtt cca ggc 499Leu Leu Ala Thr Gly Thr Pro Val Ala Arg Glu Leu Ser Val Pro Gly

120 125 130cac gat ctc aac ggc atc cat gcg gca atg gat tac ctc acc gcc caa 547His Asp Leu Asn Gly Ile His Ala Ala Met Asp Tyr Leu Thr Ala Gln

135 140 145aac cgc atc aac gaa ggc gac ggt gaa gtc tct cca atc aac gcc aaa 595Asn Arg Ile Asn Glu Gly Asp Gly Glu Val Ser Pro Ile Asn Ala Lys150 155 160 165ggc aag aaa gtt gtc atc atc ggt ggc ggc gac acc ggc acc gac tgc 643Gly Lys Lys Val Val Ile Ile Gly Gly Gly Asp Thr Gly Thr Asp Cys

170 175 180ttc ggc acc gca ctg cgc caa gga gca gaa tca gtc acc caa ttt gat 691Phe Gly Thr Ala Leu Arg Gln Gly Ala Glu Ser Val Thr Gln Phe Asp

185 190 195atc cgc ccc cgc gct cct ttc cag cgc gcc gat tcc 727Ile Arg Pro Arg Ala Pro Phe Gln Arg Ala Asp Ser

200205<210>90<211>209<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>90Met Ile Leu Ser Pro Ser Lys Thr Phe Glu Leu Glu Ile Val Glu Lys 151015 Ala Phe Arg Glu Gly Trp Val Gln Pro Val Ile Pro Ser Met Ser Thr

20 25 30Gly Leu Ser Val Ala Val Val Gly Ser Gly Pro Ala Gly Leu Ala Ala

35 40 45Ala Gln Gln Leu Thr Arg Ala Gly His Ser Val Thr Val Phe Glu Arg

50 55 60Asp Asp Arg Leu Gly Gly Leu Met Arg Tyr Gly Val Pro Glu Tyr Lys 65 7075 80Met Glu Asn Arg Trp Ile Asp Arg Arg Ile Glu Gln Met Glu Ala Glu

85 90 95Gly Thr Thr Phe Gln Val Gly Thr Ser Pro Arg Ala Ala Glu Leu Ala

100 105 110Leu Phe Asp Ala Ile Leu Leu Ala Thr Gly Thr Pro Val Ala Arg Glu

115 120 125Leu Ser Val Pro Gly His Asp Leu Asn Gly Ile His Ala Ala Met Asp

130 135 140Tyr Leu Thr Ala Gln Asn Arg Ile Asn Glu Gly Asp Gly Glu Val Ser145 150 155 160Pro Ile Asn Ala Lys Gly Lys Lys Val Val Ile Ile Gly Gly Gly Asp

165 170 175Thr Gly Thr Asp Cys Phe Gly Thr Ala Leu Arg Gln Gly Ala Glu Ser

180 185 190Val Thr Gln Phe Asp Ile Arg Pro Arg Ala Pro Phe Gln Arg Ala Asp

195200205 Ser<210>91<21l>480<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (457)<223>RXA00366<400>91aaatcatgcc gcgcgatttc caaaaagtac tcaacatcat cgaaacggcc cacgctgagg 60gccaagaccc agcaatcaag atcatggagg cagtgagcta atg gcc gac cca caa 115

Met Ala Asp Pro Gln

1 5gga ttc atc aaa tac tcc cga cgc gag cct gca cac cgc ccg gtc ccg 163Gly Phe Ile Lys Tyr Ser Arg Arg Glu Pro Ala His Arg Pro Va1 Pro

10 15 20ctg cgc ctc atg gac cac tcc gag gtc tac gaa aag gca ccg gca ggt 211Leu Arg Leu Met Asp His Ser Glu Val Tyr Glu Lys Ala Pro Ala Gly

25 30 35cag atc gag gaa cag gct gcc cgc tgc atg gat tgc ggt gtc ccg ttc 259Gln Ile Glu Glu Gln Ala Ala Arg Cys Met Asp Cys Gly Val Pro Phe

40 45 50tgc cac gaa ggc tgc cca ctg ggc aac atc atc cct gag tgg aat gat 307Cys His Glu Gly Cys Pro Leu Gly Asn Ile Ile Pro Glu Trp Asn Asp

55 60 65ctg gta cgc caa ggt cgg tgg aag gaa gcc tac gat cgc ttg cac gcg 355Leu Val Arg Gln Gly Arg Trp Lys Glu Ala Tyr Asp Arg Leu His Ala 70 75 80 85acc aac aat ttc ccc gag ttc acc ggc cgt ttg tgc ccc gca ccc tgc 403Thr Asn Asn Phe Pro Glu Phe Thr Gly Arg Leu Cys Pro Ala Pro Cys

90 95 l00gaa ggc gcc tgc gtg ctc ggt atc aac gat gat tct gtc acc atc aaa 451Glu Gly Ala Cys Val Leu Gly Ile Asn Asp Asp Ser Val Thr Ile Lys

105110115 aac gtt tgagctggaa atcgtcgaaa aag 480Asn Val<210>92<211>119<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>92Met Ala Asp Pro Gln Gly Phe Ile Lys Tyr Ser Arg Arg Glu Pro Ala 151015 His Arg Pro Val Pro Leu Arg Leu Met Asp His Ser Glu Val Tyr Glu

20 25 30Lys Ala Pro Ala Gly Gln Ile Glu Glu Gln Ala Ala Arg Cys Met Asp

35 40 45Cys Gly Val Pro Phe Cys His Glu Gly Cys Pro Leu Gly Asn Ile Ile

50 55 60Pro Glu Trp Asn Asp Leu Val Arg Gln Gly Arg Trp Lys Glu Ala Tyr 65 70 75 80Asp Arg Leu His Ala Thr Asn Asn Phe Pro Glu Phe Thr Gly Arg Leu

85 90 95Cys Pro Ala Pro Cys Glu Gly Ala Cys Val Leu Gly Ile Asn Asp Asp

100 105 110Ser Val Thr Ile Lys Asn Val

115<210>93<211>1464<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1441)<223>RXA02072<400>93tacatggtgc cctcaatggg aaccaccaac atcactaaat ggcccaggta cacactttaa 60aatcgtgcgc gcatgcagcc gagatgggaa cgaggaaatc atg aca gtt gat gag 115

Met Thr Val Asp Glu

1 5cag gtc tct aac tat tac gac atg ctt ctg aag cgc aat gct ggc gag 163Gln Val Ser Asn Tyr Tyr Asp Met Leu Leu Lys Arg Asn Ala Gly Glu

10 15 20cct gaa ttt cac cag gca gtg gca gag gtt ttg gaa tct ttg aag atc 211Pro Glu Phe His Gln Ala Val Ala Glu Val Leu Glu Ser Leu Lys Ile

25 30 35gtc ctg gaa aag gac cct cat tac gct gat tac ggt ctc atc cag cgc 259Val Leu Glu Lys Asp Pro His Tyr Ala Asp Tyr Gly Leu Ile Gln Arg

40 45 50ctg tgc gag cct gag cgt cag ctc atc ttc cgt gtg cct tgg gtt gat 307Leu Cys Glu Pro Glu Arg Gln Leu Ile Phe Arg Val Pro Trp Val Asp

55 60 65gac cag ggc cag gtc cac gtc aac cgt ggt ttc cgc gtg cag ttc aac 355Asp Gln Gly Gln Val His Val Asn Arg Gly Phe Arg Val Gln Phe Asn 70 75 80 85tct gca ctt gga cca tac aag ggc ggc ctg cgc ttc cac cca tct gta 403Ser Ala Leu Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val

90 95 100aac ctg ggc att gtg aag ttc ctg ggc ttt gag cag atc ttt aaa aac 451Asn Leu Gly Ile Val Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn

105 110 115tcc cta acc ggc ctg cca atc ggt ggt ggc aag ggt gga tcc gac ttc 499Ser Leu Thr Gly Leu Pro Ile Gly Gly Gly Lys Gly Gly Ser Asp Phe

120 125 130gac cct aag ggc aag tcc gat ctg gaa atc atg cgt ttc tgc cag tcc 547Asp Pro Lys Gly Lys Ser Asp Leu Glu Ile Met Arg Phe Cys Gln Ser

135 140 145ttc atg acc gag ctg cac cgc cac atc ggt gag tac cgc gac gtt cct 595Phe Met Thr Glu Leu His Arg His Ile Gly Glu Tyr Arg Asp Val Pro150 155 160 165gca ggt aac atc gga gtt ggt ggc cac gag atc ggt tac ctg ttt ggc 643Ala Gly Asn Ile Gly Val Gly Gly His Glu Ile Gly Tyr Leu Phe Gly

170 175 180cac tac cgt cgc atg gct aac cag cac gag tcc ggc gtt ttg acc ggt 691His Tyr Arg Arg Met Ala Asn Gln His Glu Ser Gly Val Leu Thr Gly

185 190 195aag ggc ctg acc tgg ggt gga tcc ctg gtc cgc acc gag gca act ggc 739Lys Gly Leu Thr Trp Gly Gly Ser Leu Val Arg Thr Glu Ala Thr Gly

200 205 210tac ggc tgc gtt tac ttc gtg agt gaa atg atc aag gct aag ggc gag 787Tyr Gly Cys Val Tyr Phe Val Ser Glu Met Ile Lys Ala Lys Gly Glu

215 220 225agc atc agc ggc cag aag atc atc gtt tcc ggt tcc ggc aac gta gca 835Ser Ile Ser Gly Gln Lys Ile Ile Val Ser Gly Ser Gly Asn Val Ala230 235 240 245acc tac gcg att gaa aag gct cag gaa ctc ggc gcaacc gtt att ggt 883Thr Tyr Ala Ile Glu Lys Ala Gln Glu Leu Gly Ala Thr Val Ile Gly

250 255 260ttc tcc gat tcc agc ggt tgg gtt cat acc cct aac ggc gtt gac gtg 931Phe Ser Asp Ser Ser Gly Trp Val His Thr Pro Asn Gly Val Asp Val

265 270 275gct aag ctc cgc gaa atc aag gaa gtt cgt cgc gca cgc gta tcc gtg 979Ala Lys Leu Arg Glu Ile Lys Glu Val Arg Arg Ala Arg Val Ser Val

280 285 290tac gcc gac gaa gtt gaa ggc gca acc tac cac acc gac ggt tcc atc 1027Tyr Ala Asp Glu Val Glu Gly Ala Thr Tyr His Thr Asp Gly Ser Ile

295 300 305tgg gat ctc aag tgc gat atc gct ctt cct tgt gca act cag aac gag 1075Trp Asp Leu Lys Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu310 315 320 325ctc aac ggc gag aac gct aag act ctt gca gac aac ggc tgc cgt ttc 1123Leu Asn Gly Glu Asn Ala Lys Thr Leu Ala Asp Asn Gly Cys Arg Phe

330 335 340gtt gct gaa ggc gcg aac atg cct tcc acc cct gag gct gtt gag gtc 1171Val Ala Glu Gly Ala Asn Met Pro Ser Thr Pro Glu Ala Val Glu Val

345 350 355ttc cgt gag cgc gac atc cgc ttc gga cca ggc aag gca gct aac gct 1219Phe Arg Glu Arg Asp Ile Arg Phe Gly Pro Gly Lys Ala Ala Asn Ala

360 365 370ggt ggc gtt gca acc tcc gct ctg gag atg cag cag aac gct tcg cgc 1267Gly Gly Val Ala Thr Ser Ala Leu Glu Met Gln Gln Asn Ala Ser Arg

375 380 385gat tcc tgg agc ttc gag tac acc gac gag cgc ctc cag gtg atc atg 1315Asp Ser Trp Ser Phe Glu Tyr Thr Asp Glu Arg Leu Gln Val IleMet390 395 400 405aag aac atc ttc aag acc tgt gca gag acc gca gca gag tat gga cac 1363Lys Asn Ile Phe Lys Thr Cys Ala Glu Thr Ala Ala Glu Tyr Gly His

410 415 420gag aac gat tac gtt gtc ggc gct aac att gct ggc ttc aag aag gta 1411Glu Asn Asp Tyr Val Val Gly Ala Asn Ile Ala Gly Phe Lys Lys Val

425 430 435gct gac gcg atg ctg gca cag ggc gtc atc taagacccct gcgctttact 1461Ala Asp Ala Met Leu Ala Gln Gly Val Ile

440445 taa 1464<210>94<211>447<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>94Met Thr Val Asp Glu Gln Val Ser Asn Tyr Tyr Asp Met Leu Leu Lys 151015 Arg Asn Ala Gly Glu Pro Glu Phe His Gln Ala Val Ala Glu Val Leu

20 25 30Glu Ser Leu Lys Ile Val Leu Glu Lys Asp Pro His Tyr Ala Asp Tyr

35 40 45Gly Leu Ile Gln Arg Leu Cys Glu Pro Glu Arg Gln Leu Ile Phe Arg

50 55 60Val Pro Trp Val Asp Asp Gln Gly Gln Val His Val Asn Arg Gly Phe 65 70 75 80Arg Val Gln Phe Asn Ser Ala Leu Gly Pro Tyr Lys Gly Gly Leu Arg

85 90 95Phe His Pro Ser Val Asn Leu Gly Ile Val Lys Phe Leu Gly Phe Glu

100 105 110Gln Ile Phe Lys Asn Ser Leu Thr Gly Leu Pro Ile Gly Gly Gly Lys

115 120 125Gly Gly Ser Asp Phe Asp Pro Lys Gly Lys Ser Asp Leu Glu Ile Met

130 135 140Arg Phe Cys Gln Ser Phe Met Thr Glu Leu His Arg His Ile Gly Glu145 150 155 160Tyr Arg Asp Val Pro Ala Gly Asn Ile Gly Val Gly Gly His Glu Ile

165 170 175Gly Tyr Leu Phe Gly His Tyr Arg Arg Met Ala Asn Gln His Glu Ser

180 185 190Gly Val Leu Thr Gly Lys Gly Leu Thr Trp Gly Gly Ser Leu Val Arg

195 200 205Thr Glu Ala Thr Gly Tyr Gly Cys Val Tyr Phe Val Ser Glu Met Ile

210 215 220Lys Ala Lys Gly Glu Ser Ile Ser Gly Gln Lys Ile Ile Val Ser Gly225 230 235 240Ser Gly Asn Val Ala Thr Tyr Ala Ile Glu Lys Ala Gln Glu Leu Gly

245 250 255Ala Thr Val Ile Gly Phe Ser Asp Ser Ser Gly Trp Val His Thr Pro

260 265 270Asn Gly Val Asp Val Ala Lys Leu Arg Glu Ile Lys Glu Val Arg Arg

275 280 285Ala Arg Val Ser Val Tyr Ala Asp Glu Val Glu Gly Ala Thr Tyr His

290 295 300Thr Asp Gly Ser Ile Trp Asp Leu Lys Cys Asp Ile Ala Leu Pro Cys305 310 315 320Ala Thr Gln Asn Glu Leu Asn Gly Glu Asn Ala Lys Thr Leu Ala Asp

325 330 335Asn Gly Cys Arg Phe Val Ala Glu Gly Ala Asn Met Pro Ser Thr Pro

340 345 350Glu Ala Val Glu Val Phe Arg Glu Arg Asp Ile Arg Phe Gly Pro Gly

355 360 365LysAla Ala Asn Ala Gly Gly Val Ala Thr Ser Ala Leu Glu Met Gln

370 375 380Gln Asn Ala Ser Arg Asp Ser Trp Ser Phe Glu Tyr Thr Asp Glu Arg385 390 395 400Leu Gln Val Ile Met Lys Asn Ile Phe Lys Thr Cys Ala Glu Thr Ala

405 410 415Ala Glu Tyr Gly His Glu Asn Asp Tyr Val Val Gly Ala Asn Ile Ala

420 425 430Gly Phe Lys Lys Val Ala Asp Ala Met Leu Ala Gln Gly Val Ile

435440445<210>95<211>1461<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1438)<223>RXA00323<400>95cgcgacatcc ttgagtaact ctgagaaaaa ctacccccga tgggagtata aaagtggcaa 60atgcgcagtc gatgtcccat cgctgcgtag attagttttc atg aac agc gaa cag 115

Met Asn Ser Glu Gln

1 5gaa ttt gta ctc agc gcc att gaa gaa cgc gac att aag ttt gtg cgt 163Glu Phe Val Leu Ser Ala Ile Glu Glu Arg Asp Ile Lys Phe Val Arg

10 15 20cta tgg ttc act gac att ctt ggc cac ttg aag tca gtg gtt gtg gct 211Leu Trp Phe Thr Asp Ile Leu Gly His Leu Lys Ser Val Val Val Ala

25 30 35cct gca gaa cta gag tct gcg ttg gaa gaa ggc atc gga ttc gat ggc 259Pro Ala Glu Leu Glu Ser Ala Leu Glu Glu Gly Ile Gly Phe Asp Gly

40 45 50tca gcc att gag ggc tac gcg cgt atc tcg gaa gcg gac acc att gcc 307Ser Ala Ile Glu Gly Tyr Ala Arg Ile Ser Glu Ala Asp Thr Ile Ala

55 60 65cgc cca gat cca tcg aca ttc cag gtc ctc cca cta gaa gcg ggc atc 355Arg Pro Asp Pro Ser Thr Phe Gln Val Leu Pro Leu Glu Ala Gly Ile 70 75 80 85tca aaa ctg cag gca gca cgc ctg ttt tgc gat gtc acg atg cca gac 403Ser Lys Leu Gln Ala Ala Arg Leu Phe Cys Asp Val Thr Met Pro Asp

90 95 100gga cag cca tct ttt tct gac ccg cgc caa gtg ctg cgc agg cag gtc 451Gly Gln Pro Ser Phe Ser Asp Pro Arg Gln Val Leu Arg Arg Gln Val

105 110 115caa cta gct gca gat gaa ggc ttg acc tgc atg atc tca cca gag att 499Gln Leu Ala Ala Asp Glu Gly Leu Thr Cys Met Ile Ser Pro Glu Ile

120 125 130gag ttc tat ttg gtg caa agc ctt cgc acc aac gga ctg cca cct gtg 547Glu Phe Tyr Leu Val Gln Ser Leu Arg Thr Asn Gly Leu Pro Pro Val

135 140 145ccc act gac aac ggc gga tat ttc gac caa gcc aca ttc aat gag gcg 595Pro Thr Asp Asn Gly Gly Tyr Phe Asp Gln Ala Thr Phe Asn Glu Ala150 155 160 165ccg aat ttc cgt cga aac gcg atg gta gcg ctg gag gaa ctc ggc atc 643Pro Asn Phe Arg Arg Asn Ala Met Val Ala Leu Glu Glu Leu Gly Ile

170 175 180cct gtc gag ttc tcc cac cat gaa act gca cct ggc cag caa gaa atc 691Pro Val Glu Phe Ser His His Glu Thr Ala Pro Gly Gln Gln Glu Ile

185 190 195gat tta cgc cat gcg gat gcg ctc acc atg gcc gac aac atc atg acc 739Asp Leu Arg His Ala Asp Ala Leu Thr Met Ala Asp Asn Ile Met Thr

200 205 210ttc cgc tac atc atg aaa cag gtg gca agg gac caa ggc gtc ggg gca 787Phe Arg Tyr Ile Met Lys Gln Val Ala Arg Asp Gln Gly Val Gly Ala

215 220 225tca ttt atg ccc aag cca ttc caa gaa cat gca ggc tcc gcc atg cac 835Ser Phe Met Pro Lys Pro Phe Gln Glu His Ala Gly Ser Ala Met His230 235 240 245acg cac atg tcc tta ttt gag ggc gat acc aac gcg ttc cac gat cca 883Thr His Met Ser Leu Phe Glu Gly Asp Thr Asn Ala Phe His Asp Pro

250 255 260gac gat tct tac atg ctg tcc aaa acc gca aaa cag ttc atc gct gga 931Asp Asp Ser Tyr Met Leu Ser Lys Thr Ala Lys Gln Phe Ile Ala Gly

265 270 275atc ttg cat cac gct cca gaa ttc acc gct gtg acc aac cag tgg gtc 979Ile Leu His His Ala Pro Glu Phe Thr Ala Val Thr Asn Gln Trp Val

280 285 290aat tcc tac aaa cgc atc gtg tac gga aac gaa gct cca act gcg gca 1027Asn Ser Tyr Lys Arg Ile Val Tyr Gly Asn Glu Ala Pro Thr Ala Ala

295 300 305acc tgg ggt gta tct aat cgt tct gcg ctg gtt cgt gtt cct acc tac 1075Thr Trp Gly Val Ser Asn Arg Ser Ala Leu Val Arg Val Pro Thr Tyr310 315 320 325cgt ttg aat aag gag gag tcg cgc cgg gtg gag gtg cgt ctt cct gat 1123Arg Leu Asn Lys Glu Glu Ser Arg Arg Val Glu Val Arg Leu Pro Asp

330 335 340acc gct tgt aac cca tat ttg gcg ttt tca gtg atg ctc ggc gct ggt 1171Thr Ala Cys Asn Pro Tyr Leu Ala Phe Ser Val Met Leu Gly Ala Gly

345 350 355ttg aaa ggc att aaa gaa ggt tat gag ctc gac gag cca gct gag gac 1219Leu Lys Gly Ile Lys Glu Gly Tyr Glu Leu Asp Glu Pro Ala Glu Asp

360 365 370gat atc tcc aac ttg agc ttc cgg gaa cgt cgc gcc atg ggc tac aac 1267Asp Ile Ser Asn Leu Ser Phe Arg Glu Arg Arg Ala Met Gly Tyr Asn

375 380 385gat ctg cca agc agc ctt gat cag gca ctg cgc caa atg gaa aag tca 1315Asp Leu Pro Ser Ser Leu Asp Gln Ala Leu Arg Gln Met Glu Lys Ser390 395 400 405gag ctt gtt gct gac atc ctc ggt gag cac gtt ttt gag ttt ttc ttg 1363Glu Leu Val Ala Asp Ile Leu Gly Glu His Val Phe Glu Phe Phe Leu

410 415 420cgc aat aag tgg cgt gaa tgg cgt gac tac caa gag cag atc act ccg 1411Arg Asn Lys Trp Arg Glu Trp Arg Asp Tyr Gln Glu Gln Ile Thr Pro

425 430 435tgg gag ctc cga aac aat ctt gat tac tagacttttg cactccaatg 1458Trp Glu Leu Arg Asn Asn Leu Asp Tyr

440445 gaa 1461<210>96<211>446<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>96Met Asn Ser Glu Gln Glu Phe Val Leu Ser Ala Ile Glu Glu Arg Asp 15l 015 Ile Lys Phe Val Arg Leu Trp Phe Thr Asp Ile Leu Gly His Leu Lys

20 25 30Ser Val Val Val Ala Pro Ala Glu Leu Glu Ser Ala Leu Glu Glu Gly

35 40 45Ile Gly Phe Asp Gly Ser Ala Ile Glu Gly Tyr Ala Arg Ile Ser Glu

50 55 60Ala Asp Thr Ile Ala Arg Pro Asp Pro Ser Thr Phe Gln Val Leu Pro 65 70 75 80Leu Glu Ala Gly Ile Ser Lys Leu Gln Ala Ala Arg Leu Phe Cys Asp

85 90 95Val Thr Met Pro Asp Gly Gln Pro Ser Phe Ser Asp ProArg Gln Val

100 105 110Leu Arg Arg Gln Val Gln Leu Ala Ala Asp Glu Gly Leu Thr Cys Met

115 120 125Ile Ser Pro Glu Ile Glu Phe Tyr Leu Val Gln Ser Leu Arg Thr Asn

130 135 140Gly Leu Pro Pro Val Pro Thr Asp Asn Gly Gly Tyr Phe Asp Gln Ala145 150 155 160Thr Phe Asn Glu Ala Pro Asn Phe Arg Arg Asn Ala Met Val Ala Leu

165 170 175Glu Glu Leu Gly Ile Pro Val Glu Phe Ser His His Glu Thr Ala Pro

180 185 190Gly Gln Gln Glu Ile Asp Leu Arg His Ala Asp Ala Leu Thr Met Ala

195 200 205Asp Asn Ile Met Thr Phe Arg Tyr Ile Met Lys Gln Val Ala Arg Asp

210 215 220Gln Gly Val Gly Ala Ser Phe Met Pro Lys Pro Phe Gln Glu His Ala225 230 235 240Gly Ser Ala Met His Thr His Met Ser Leu Phe Glu Gly Asp Thr Asn

245 250 255Ala Phe His Asp Pro Asp Asp Ser Tyr Met Leu Ser Lys Thr Ala Lys

260 265 270Gln Phe Ile Ala Gly Ile Leu His His Ala Pro Glu Phe Thr Ala Val

275 280 285Thr Asn Gln Trp Val Asn Ser Tyr Lys Arg Ile Val Tyr Gly Asn Glu

290 295 300Ala Pro Thr Ala Ala Thr Trp Gly Val Ser Asn Arg Ser Ala Leu Val305 310 315 320Arg Val Pro Thr Tyr Arg Leu Asn Lys Glu Glu Ser Arg Arg Val Glu

325 330 335Val Arg Leu Pro Asp Thr Ala Cys Asn Pro Tyr Leu Ala Phe Ser Val

340 345 350Met Leu Gly Ala Gly Leu Lys Gly Ile Lys Glu Gly Tyr Glu Leu Asp

355 360 365Glu Pro Ala Glu Asp Asp Ile Ser Asn Leu Ser Phe Arg Glu Arg Arg

370 375 380Ala Met Gly Tyr Asn Asp Leu Pro Ser Ser Leu Asp Gln Ala Leu Arg385 390 395 400Gln Met Glu Lys Ser Glu Leu Val Ala Asp Ile Leu Gly Glu His Val

405 410 415Phe Glu Phe Phe Leu Arg Asn Lys Trp Arg Glu Trp Arg Asp Tyr Gln

420 425 430Glu Gln Ile Thr Pro Trp Glu Leu Arg Asn Asn Leu Asp Tyr

435440445<210>97<211>1554<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1531)<223>RXA00335<400>97actacatttg cagccaagtc tactacttga tcttcaaagg tcagcaattg tgaacaaagc 60tacaaataaa ccgttccgcc catgtcaatg aggagtcacc gtg gcg ttt gaa acc 115

Val Ala Phe Glu Thr

1 5ccg gaa gaa att gtc aag ttc atc aag gat gaa aac gtc gag ttc gtt 163Pro Glu Glu Ile Val Lys Phe Ile Lys Asp Glu Asn Val Glu Phe Val

10 15 20gac gtt cga ttc acc gac ctt ccc ggc acc gag cag cac ttc agc atc 211Asp Val Arg Phe Thr Asp Leu Pro Gly Thr Glu Gln His Phe Ser Ile

25 3035cca gct gcc agc ttc gat gca gat aca atc gaa gaa ggt ctc gca ttc 259Pro Ala Ala Ser Phe Asp Ala Asp Thr Ile Glu Glu Gly Leu Ala Phe

40 45 50gac gga tcc tcg atc cgt ggc ttc acc acg atc gac gaa tct gac atg 307Asp Gly Ser Ser Ile Arg Gly Phe Thr Thr Ile Asp Glu Ser Asp Met

55 60 65aat ctc ctg cca gac ctc gga acg gcc acc ctt gat cca ttc cgc aag 355Asn Leu Leu Pro Asp Leu Gly Thr Ala Thr Leu Asp Pro Phe Arg Lys 70 75 80 85gca aag acc ctg aac gtt aag ttc ttc gtt cac gat cct ttc acc cgc 403Ala Lys Thr Leu Asn Val Lys Phe Phe Val His Asp Pro Phe Thr Arg

90 95 100gag gca ttc tcc cgc gac cca cgc aac gtg gca cgc aag gca gag cag 451Glu Ala Phe Ser Arg Asp Pro Arg Asn Val Ala Arg Lys Ala Glu Gln

105 110 115tac ctg gca tcc acc ggc att gca gac acc tgc aac ttc ggc gcc gag 499Tyr Leu Ala Ser Thr Gly Ile Ala Asp Thr Cys Asn Phe Gly Ala Glu

120 125 130gct gag ttc tac ctc ttc gac tcc gtt cgc tac tcc acc gag atg aac 547Ala Glu Phe Tyr Leu Phe Asp Ser Val Arg Tyr Ser Thr Glu Met Asn

135 140 145tcc ggc ttc tac gaa gta gat acc gaa gaa ggc tgg tgg aac cgt ggc 595Ser Gly Phe Tyr Glu Val Asp Thr Glu Glu Gly Trp Trp Asn Arg Gly150 155 160 165aag gaa acc aac ctc gac ggc acc cca aac ctg ggc gca aag aac cgc 643Lys Glu Thr Asn Leu Asp Gly Thr Pro Asn Leu Gly Ala Lys Asn Arg

170 175 180gtc aag ggt ggc tac ttc cca gta gca cca tac gac caa acc gtt gac 691Val Lys Gly Gly Tyr Phe Pro Val AlaPro Tyr Asp Gln Thr Val Asp

185 190 195gtg cgc gat gac atg gtt cgc aac ctc gca gct tcc ggc ttc gct ctt 739Val Arg Asp Asp Met Val Arg Asn Leu Ala Ala Ser Gly Phe Ala Leu

200 205 210gag cgt ttc cac cac gaa gtc ggt ggc gga cag cag gaa atc aac tac 787Glu Arg Phe His His Glu Val Gly Gly Gly Gln Gln Glu Ile Asn Tyr

215 220 225cgc ttc aac acc atg ctc cac gcg gca gat gat atc cag acc ttc aag 835Arg Phe Asn Thr Met Leu His Ala Ala Asp Asp Ile Gln Thr Phe Lys230 235 240 245tac atc atc aag aac acc gct cgc ctc cac ggc aag gct gca acc ttc 883Tyr Ile Ile Lys Asn Thr Ala Arg Leu His Gly Lys Ala Ala Thr Phe

250 255 260atg cct aag cca ctg gct ggc gac aac ggt tcc ggc atg cac gct cac 931Met Pro Lys Pro Leu Ala Gly Asp Asn Gly Ser Gly Met His Ala His

265 270 275cag tcc ctc tgg aag gac ggc aag cca ctc ttc cac gat gag tcc ggc 979Gln Ser Leu Trp Lys Asp Gly Lys Pro Leu Phe His Asp Glu Ser Gly

280 285 290tac gca ggc ctg tcc gac atc gcc cgc tac tac atc ggc ggc atc ctg 1027Tyr Ala Gly Leu Ser Asp Ile Ala Arg Tyr Tyr Ile Gly Gly Ile Leu

295 300 305cac cac gca ggc gct gtt ctg gcg ttc acc aac gca acc ctg aac tcc 1075His His Ala Gly Ala Val Leu Ala Phe Thr Asn Ala Thr Leu Asn Ser310 315 320 325tac cac cgt ctg gtt cca ggc ttc gag gct cca atc aac ctg gtg tac 1123Tyr His Arg Leu Val Pro Gly Phe Glu Ala Pro Ile Asn Leu Val Tyr

330 335 340tca cag cgc aac cgt tcc gct gct gtc cgt atc cca atc acc gga tcc 1171Ser Gln Arg Asn Arg Ser Ala Ala Val Arg Ile Pro Ile Thr Gly Ser

345 350 355aac ccg aag gca aag cgc atc gaa ttc cgc gct cca gac cca tca ggc 1219Asn Pro Lys Ala Lys Arg Ile Glu Phe Arg Ala Pro Asp Pro Ser Gly

360 365 370aac cca tac ctg ggc ttt gca gcg atg atg atg gcc ggc ctc gac ggc 1267Asn Pro Tyr Leu Gly Phe Ala Ala Met Met Met Ala Gly Leu Asp Gly

375 380 385atc aag aac cgc atc gag cca cac gct cca gtg gac aag gac ctc tac 1315Ile Lys Asn Arg Ile Glu Pro His Ala Pro Val Asp Lys Asp Leu Tyr390 395 400 405gaa cta cca cca gag gaa gct gca tcc att cca cag gca cca acc tcc 1363Glu Leu Pro Pro Glu Glu Ala Ala Ser Ile Pro Gln Ala Pro Thr Ser

410 415 420ctg gaa gca tcc ctg aag gca ctg cag gaa gac acc gac ttc ctc acc 1411Leu Glu Ala Ser Leu Lys Ala Leu Gln Glu Asp Thr Asp Phe Leu Thr

425 430 435gag tct gac gtc ttc acc gag gat ctc atc gag gcg tac atc cag tac 1459Glu Ser Asp Val Phe Thr Glu Asp Leu Ile Glu Ala Tyr Ile Gln Tyr

440 445 450aag tac gac aac gag atc tcc cca gtt cgc ctg cgc cca acc ccg cag 1507Lys Tyr Asp Asn Glu Ile Ser Pro Val Arg Leu Arg Pro Thr Pro Gln

455460465 gaa ttc gaa ttg tac ttc gac tgc taattcactt agctagccga tag 1554Glu Phe Glu Leu Tyr Phe Asp Cys 470475<210>98<211>477<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>98Val Ala Phe Glu Thr Pro Glu Glu Ile Val Lys Phe Ile Lys Asp Glu 151015 Asn Val Glu Phe Val Asp Val Arg Phe ThrAsp Leu Pro Gly Thr Glu

20 25 30Gln His Phe Ser Ile Pro Ala Ala Ser Phe Asp Ala Asp Thr Ile Glu

35 40 45Glu Gly Leu Ala Phe Asp Gly Ser Ser Ile Arg Gly Phe Thr Thr Ile

50 55 60Asp Glu Ser Asp Met Asn Leu Leu Pro Asp Leu Gly Thr Ala Thr Leu 65 70 75 80Asp Pro Phe Arg Lys Ala Lys Thr Leu Asn Val Lys Phe Phe Val His

85 90 95Asp Pro Phe Thr Arg Glu Ala Phe Ser Arg Asp Pro Arg Asn Val Ala

100 105 110Arg Lys Ala Glu Gln Tyr Leu Ala Ser Thr Gly Ile Ala Asp Thr Cys

115 120 125Asn Phe Gly Ala Glu Ala Glu Phe Tyr Leu Phe Asp Ser Val Arg Tyr

130 135 140Ser Thr Glu Met Asn Ser Gly Phe Tyr Glu Val Asp Thr Glu Glu Gly145 150 155 160Trp Trp Asn Arg Gly Lys Glu Thr Asn Leu Asp Gly Thr Pro Asn Leu

165 170 175Gly Ala Lys Asn Arg Val Lys Gly Gly Tyr Phe Pro Val Ala Pro Tyr

180 185 190Asp Gln Thr Val Asp Val Arg Asp Asp Met Val Arg Asn Leu Ala Ala

195 200 205Ser Gly Phe Ala Leu Glu Arg Phe His His Glu Val Gly Gly Gly Gln

210 215 220Gln Glu Ile Asn Tyr Arg Phe Asn Thr Met Leu His Ala Ala Asp Asp225 230 235 240Ile Gln Thr Phe Lys Tyr Ile Ile Lys Asn Thr Ala Arg LeuHis Gly

245 250 255Lys Ala Ala Thr Phe Met Pro Lys Pro Leu Ala Gly Asp Asn Gly Ser

260 265 270Gly Met His Ala His Gln Ser Leu Trp Lys Asp Gly Lys Pro Leu Phe

275 280 285His Asp Glu Ser Gly Tyr Ala Gly Leu Ser Asp Ile Ala Arg Tyr Tyr

290 295 300Ile Gly Gly Ile Leu His His Ala Gly Ala Val Leu Ala Phe Thr Asn305 310 315 320Ala Thr Leu Asn Ser Tyr His Arg Leu Val Pro Gly Phe Glu Ala Pro

325 330 335Ile Asn Leu Val Tyr Ser Gln Arg Asn Arg Ser Ala Ala Val Arg Ile

340 345 350Pro Ile Thr Gly Ser Asn Pro Lys Ala Lys Arg Ile Glu Phe Arg Ala

355 360 365Pro Asp Pro Ser Gly Asn Pro Tyr Leu Gly Phe Ala Ala Met Met Met

370 375 380Ala Gly Leu Asp Gly Ile Lys Asn Arg Ile Glu Pro His Ala Pro Val385 390 395 400Asp Lys Asp Leu Tyr Glu Leu Pro Pro Glu Glu Ala Ala Ser Ile Pro

405 410 415Gln Ala Pro Thr Ser Leu Glu Ala Ser Leu Lys Ala Leu Gln Glu Asp

420 425 430Thr Asp Phe Leu Thr Glu Ser Asp Val Phe Thr Glu Asp Leu Ile Glu

435 440 445Ala Tyr Ile Gln Tyr Lys Tyr Asp Asn Glu Ile Ser Pro Val Arg Leu

450455460 Arg Pro Thr Pro Gln Glu Phe Glu Leu Tyr Phe Asp Cys 465470475<210>99<211>3258<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (3235)<223>RXA00324<400>99tccgtgggag ctccgaaaca atcttgatta ctagactttt gcactccaat ggaaacccta 60cggcgaccca attgcgaccc gatgaaggag gggagaagct atg tca gga ccg tta 115

Met Ser Gly Pro Leu

1 5aga agt gaa cgt aaa gtc gtt ggc ttt gtc aga gac cca ctg cca aaa 163Arg Ser Glu Arg Lys Val Val Gly Phe Val Arg Asp Pro Leu Pro Lys

10 15 20gtt ggt tct tta tcg ctg aaa tct gag cat gcc caa gca gat cta gag 211Val Gly Ser Leu Ser Leu Lys Ser Glu His Ala Gln Ala Asp Leu Glu

25 30 35cat ttg ggt tgg cgc aat gtt gag tct ttg gat ttg ttg tgg ggc ttg 259His Leu Gly Trp Arg Asn Val Glu Ser Leu Asp Leu Leu Trp Gly Leu

40 45 50tca ggt gca ggc gat ccc gat gtc gcg ctg aac ctt ctt att cgg ctg 307Ser Gly Ala Gly Asp Pro Asp Val Ala Leu Asn Leu Leu Ile Arg Leu

55 60 65tat cag gca ctt gaa gca atc ggc gag gat gct cga aac gag ctt gat 355Tyr Gln Ala Leu Glu Ala Ile Gly Glu Asp Ala Arg Asn Glu Leu Asp 70 75 80 85caa gag att cgc cag gat gaa aaa cta cga gtc cgc ctt ttt gca ttg 403Gln Glu Ile Arg Gln Asp Glu Lys Leu Arg Val Arg Leu Phe Ala Leu

90 95 100ttg ggt ggt tcc tcg gct gtc ggt gat cac ttg gtc gcc aat cct ttg 451Leu Gly Gly Ser Ser Ala Val Gly Asp His Leu Val Ala Asn Pro Leu

105 110 115cag tgg aaa ctc tta aaa ctt gat gcg cca tcg agg gaa gag atg ttt 499Gln Trp Lys Leu Leu Lys Leu Asp Ala Pro Ser Arg Glu Glu Met Phe

120 125 130cag gcg ctg ctg gaa tct gtg aaa gct cag cct gct gtg ctt gag gtt 547Gln Ala Leu Leu Glu Ser Val Lys Ala Gln Pro Ala Val Leu Glu Val

135 140 145gag gat ttc agc gat gca cac aac att gcc cga gac gat ttg agc acg 595Glu Asp Phe Ser Asp Ala His Asn Ile Ala Arg Asp Asp Leu Ser Thr150 155 160 165cct ggt ttt tac acg gct agt gtt acc ggg cct gaa gca gag cga gtc 643Pro Gly Phe Tyr Thr Ala Ser Val Thr Gly Pro Glu Ala Glu Arg Val

170 175 180ttg aaa tgg act tat cgc acg ttg ctg acc cgg att gct gcg cat gat 691Leu Lys Trp Thr Tyr Arg Thr Leu Leu Thr Arg Ile Ala Ala His Asp

185 190 195tta gcg ggt acc tat ccc acc gac atg cgg aga aaa ggt ggc gat cct 739Leu Ala Gly Thr Tyr Pro Thr Asp Met Arg Arg Lys Gly Gly Asp Pro

200 205 210gtt ccg ttt agc aca gtg acc atg cag ctc agc gac cta gct gat gct 787Val Pro Phe Ser Thr Val Thr Met Gln Leu Ser Asp Leu Ala Asp Ala

215 220 225gct ttg act gct gct tta gct gtg gca att gcc aat gtt tat ggt gaa 835Ala Leu Thr Ala Ala Leu Ala Val Ala Ile Ala Asn Val Tyr Gly Glu230 235 240 245aag ccg gtt gat tca gct tta tct gtc atc gcg atg ggc aaa tgt ggc 883Lys Pro Val Asp Ser Ala Leu Ser Val Ile Ala Met Gly Lys Cys Gly

250 255 260gcg cag gaa ttg aac tac att tca gat gtg gac gtg gtg ttt gtt gca 931Ala Gln Glu Leu Asn Tyr Ile Ser Asp Val Asp Val Val Phe Val Ala

265 270 275gag ccg gca aac tct aaa tca aca cgc acc gca gca gag ctc att cgc 979Glu Pro Ala Asn Ser Lys Ser Thr Arg Thr Ala Ala Glu Leu Ile Arg

280 285 290atc ggt agc aac tcg ttc ttt gag gtg gat gca gca ctt cgc cca gaa 1027Ile Gly Ser Asn Ser Phe Phe Glu Val Asp Ala Ala Leu Arg Pro Glu

295 300 305ggt aaa agt ggc gct ctt gtg cgc tct ttg gat tcc cat atg gcg tat 1075Gly Lys Ser Gly Ala Leu Val Arg Ser Leu Asp Ser His Met Ala Tyr310 315 320 325tac aag cgc tgg gcg gaa acc tgg gag ttt cag gca ctg ctg aaa gct 1123Tyr Lys Arg Trp Ala Glu Thr Trp Glu Phe Gln Ala Leu Leu Lys Ala

330 335 340cgt ccc atg acg ggt gat att aac ctt ggg cag tcc tat gtg gat gct 1171Arg Pro Met Thr Gly Asp Ile Asn Leu Gly Gln Ser Tyr Val Asp Ala

345 350 355ctt tca ccg ttg att tgg acg gct agc cag cgg gaa tca ttt gtc aca 1219Leu Ser Pro Leu Ile Trp Thr Ala Ser Gln Arg Glu Ser Phe Val Thr

360 365 370gat gtc caa gct atg cgc cgt cga gtg ttg gac aat gtt ccg gaa gac 1267Asp Val Gln Ala Met Arg Arg Arg Val Leu Asp Asn Val Pro Glu Asp

375 380 385ttg cgt gat cgt gag ctg aag ctt ggt cgc ggt ggt ttg agg gat gtg 1315Leu Arg Asp Arg Glu Leu Lys Leu Gly Arg Gly Gly Leu Arg Asp Val390 395 400 405gag ttt gct gtc cag ctc ctt cag atg gtg cat ggt cgc att gat gag 1363Glu Phe Ala Val Gln Leu Leu Gln Met Val His Gly Arg Ile Asp Glu

410 415 420acg ttg cgg gtt cgg tca acg gta aat gctttg cat gtg ttg gtt gat 1411Thr Leu Arg Val Arg Ser Thr Val Asn Ala Leu His Val Leu Val Asp

425 430 435cag gga tat gtg ggt cgt gaa gac ggg cat aat ctc att gag tcg tat 1459Gln Gly Tyr Val Gly Arg Glu Asp Gly His Asn Leu Ile Glu Ser Tyr

440 445 450gag ttt ttg cgt ctg ttg gag cat cgc ctt caa ttg gag cgg atc aag 1507Glu Phe Leu Arg Leu Leu Glu His Arg Leu Gln Leu Glu Arg Ile Lys

455 460 465cgc act cac ttg tta ccg aaa cct gat gac cga atg aat atg cgc tgg 1555Arg Thr His Leu Leu Pro Lys Pro Asp Asp Arg Met Asn Met Arg Trp470 475 480 485ttg gcg cgc gct tct ggg ttt act ggt tcg atg gag caa agt tcg gcc 1603Leu Ala Arg Ala Ser Gly Phe Thr Gly Ser Met Glu Gln Ser Ser Ala

490 495 500aaa gct atg gaa cgg cat ttg cgt aag gtt cgt ttg cag att cag tcg 1651Lys Ala Met Glu Arg His Leu Arg Lys Val Arg Leu Gln Ile Gln Ser

505 510 515ttg cat agt cag ctg ttt tat cgg cca ctg ctg aac tct gtg gtc aac 1699Leu His Ser Gln Leu Phe Tyr Arg Pro Leu Leu Asn Ser Val Val Asn

520 525 530ttg agc gcg gat gcc atc agg ttg tct ccg gat gct gca aag cta caa 1747Leu Ser Ala Asp Ala Ile Arg Leu Ser Pro Asp Ala Ala Lys Leu Gln

535 540 545ttg gcg gca ttg gga tac ctg cat cca tca cgt gct tat gaa cac ctg 1795Leu Ala Ala Leu Gly Tyr Leu His Pro Ser Arg Ala Tyr Glu His Leu550 555 560 565act gct ctt gca tca gga gct agc cgt aaa gcc aag att cag gcg atg 1843Thr Ala Leu Ala Ser Gly Ala Ser Arg Lys Ala Lys Ile Gln Ala Met

570 575 580ttg ctg ccc acg ttg atg gag tgg ctg tct caa aca gct gaa cca gat 1891Leu Leu Pro Thr Leu Met Glu Trp Leu Ser Gln Thr Ala Glu Pro Asp

585 590 595gcg gga ttg ctg aat tac cgc aag ctt tct gat gct tcc tat gat cgc 1939Ala Gly Leu Leu Asn Tyr Arg Lys Leu Ser Asp Ala Ser Tyr Asp Arg

600 605 610agc tgg ttt ttg cgc atg ctg cgt gat gag ggc gta gtg ggg cag cgg 1987Ser Trp Phe Leu Arg Met Leu Arg Asp Glu Gly Val Val Gly Gln Arg

615 620 625ttg atg cgt att ttg gga aat tct ccc tat att tct gaa ctg att atc 2035Leu Met Arg Ile Leu Gly Asn Ser Pro Tyr Ile Ser Glu Leu Ile Ile630 635 640 645tcc act ccg gac ttt atg aaa cag ctg ggt gat gcg gcg tct ggt cct 2083Ser Thr Pro Asp Phe Met Lys Gln Leu Gly Asp Ala Ala Ser Gly Pro

650 655 660aaa ttg ctt gct act gca ccg act cag gtt gtg aaa gca atc aag gca 2131Lys Leu Leu Ala Thr Ala Pro Thr Gln Val Val Lys Ala Ile Lys Ala

665 670 675acg gtg tcg cgt cat gag tca cct gat cgg gcg atc cag gct gca cga 2179Thr Val Ser Arg His Glu Ser Pro Asp Arg Ala Ile Gln Ala Ala Arg

680 685 690tcg ctg agg agg cag gag ctg gca cgc att gcc tct gct gat ttg ctc 2227Ser Leu Arg Arg Gln Glu Leu Ala Arg Ile Ala Ser Ala Asp Leu Leu

695 700 705aac atg ctc act gtt cag gaa gta tgc caa agc ttg tca cta gtc tgg 2275Asn Met Leu Thr Val Gln Glu Val Cys Gln Ser Leu Ser Leu Val Trp710 715 720 725gat gcg gtg ttg gat gct gcc ttg gat gcg gaa atc cgt gct gca ctt 2323Asp Ala Val Leu Asp Ala Ala Leu Asp Ala Glu Ile Arg Ala Ala Leu

730 735 740aac gat cca cag aaa cca gat cag cct ctg gcc aat att tct gtg atc 2371Asn Asp Pro Gln Lys Pro Asp Gln Pro Leu Ala Asn Ile Ser Val Ile

745 750 755ggc atg ggc cgt ttg ggt gga gca gaa ctt gga tac ggt tct gat gcc 2419Gly Met Gly Arg Leu Gly Gly Ala Glu Leu Gly Tyr Gly Ser Asp Ala

760 765 770gat gtg atg ttt gta tgc gag ccg gta gcc ggt gtg gaa gag cat gag 2467Asp Val Met Phe Val Cys Glu Pro Val Ala Gly Val Glu Glu His Glu

775 780 785gcc gtc aca tgg tct att gct atc tgt gat tcc atg cgg tcg agg ctt 2515Ala Val Thr Trp Ser Ile Ala Ile Cys Asp Ser Met Arg Ser Arg Leu790 795 800 805gcg cag cct tcc ggt gat cca cct ttg gag gtg gat ctg ggg ctg cgt 2563Ala Gln Pro Ser Gly Asp Pro Pro Leu Glu Val Asp Leu Gly Leu Arg

810 815 820cct gaa ggg aga tct ggt gcg att gtg cgc acc gtt gat tcc tat gtg 2611Pro Glu Gly Arg Ser Gly Ala Ile Val Arg Thr Val Asp Ser Tyr Val

825 830 835aag tac tac gaa aag tgg ggt gaa act tgg gag att cag gcg ctg ctg 2659Lys Tyr Tyr Glu Lys Trp Gly Glu Thr Trp Glu Ile Gln Ala Leu Leu

840 845 850agg gct gcg tgg gtt gct ggt gat cgt gag ctg ggt att aag ttc ttg 2707Arg Ala Ala Trp Val Ala Gly Asp Arg Glu Leu Gly Ile Lys Phe Leu

855 860 865gag tcg att gat cgt ttc cgc tac cca gtt gac ggg gca acg cag gcg 2755Glu Ser Ile Asp Arg Phe Arg Tyr Pro Val Asp Gly AlaThr Gln Ala870 875 880 885cag ctt cgt gaa gtt cgt cga att aag gcg agg gtg gat aat gag agg 2803Gln Leu Arg Glu Val Arg Arg Ile Lys Ala Arg Val Asp Asn Glu Arg

890 895 900ctt ccg cgc ggg gct gat cga aat acc cat acc aag ctg ggt cgg gga 2851Leu Pro Arg Gly Ala Asp Arg Asn Thr His Thr Lys Leu Gly Arg Gly

905 910 915gcg tta act gac atc gag tgg act gtg cag ttg ttg acc atg atg cat 2899Ala Leu Thr Asp Ile Glu Trp Thr Val Gln Leu Leu Thr Met Met His

920 925 930gct cat gag att ccg gag ctg cac aat acg tcg acg ttg gaa gtt ctt 2947Ala His Glu Ile Pro Glu Leu His Asn Thr Ser Thr Leu Glu Val Leu

935 940 945gaa gtg ctg gaa aag cat cag att att aac cct gtg cag gtg cag acg 2995Glu Val Leu Glu Lys His Gln Ile Ile Asn Pro Val Gln Val Gln Thr950 955 960 965ctt cgg gaa gcg tgg ctg acg gca acg gct gct agg aat gcg ctt gtg 3043Leu Arg Glu Ala Trp Leu Thr Ala Thr Ala Ala Arg Asn Ala Leu Val

970 975 980ctg gtc agg ggt aag aga tta gat cag tta cct act cct ggt ccg cac 3091Leu Val Arg Gly Lys Arg Leu Asp Gln Leu Pro Thr Pro Gly Pro His

985 990 995ctt gcg cag gtg gct ggt gcg tct ggt tgg gat cca aat gag tac cag 3139Leu Ala Gln Val Ala Gly Ala Ser Gly Trp Asp Pro Asn Glu Tyr Gln

1000 1005 1010gag tat ttg gaa aac tat ctg aaa gtg acc agg aag agt cgt cag gtt 3187Glu Tyr Leu Glu Asn Tyr Leu Lys Val Thr Arg Lys Ser Arg Gln Val

101510201025 gtt gat gaa gtc ttc tgg ggt gtg gac tct atg gag caa cgt gag ttt 3235Val Asp Glu Val Phe Trp Gly Val Asp Ser Met Glu Gln Arg Glu Phe 1030103510401045 taggtaggtg gtgggagccc caa 3258<210>100<211>1045<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>100Met Ser Gly Pro Leu Arg Ser Glu Arg Lys Val Val Gly Phe Val Arg l 51015 Asp Pro Leu Pro Lys Val Gly Ser Leu Ser Leu Lys Ser Glu His Ala

20 25 30Gln Ala Asp Leu Glu His Leu Gly Trp Arg Asn Val Glu Ser Leu Asp

35 40 45Leu Leu Trp Gly Leu Ser Gly Ala Gly Asp Pro Asp Val Ala Leu Asn

50 55 60Leu Leu Ile Arg Leu Tyr Gln Ala Leu Glu Ala Ile Gly Glu Asp Ala 65 70 75 80Arg Asn Glu Leu Asp Gln Glu Ile Arg Gln Asp Glu Lys Leu Arg Val

85 90 95Arg Leu Phe Ala Leu Leu Gly Gly Ser Ser Ala Val Gly Asp His Leu

100 105 110Val Ala Asn Pro Leu Gln Trp Lys Leu Leu Lys Leu Asp Ala Pro Ser

115 120 125Arg Glu Glu Met Phe Gln Ala Leu Leu Glu Ser Val Lys Ala Gln Pro

130 135 140Ala Val Leu Glu Val Glu Asp Phe Ser Asp Ala His Asn Ile Ala Arg145 150 155 160Asp Asp Leu Ser Thr Pro Gly Phe Tyr Thr Ala Ser Val Thr Gly Pro

165 170 175Glu Ala Glu Arg Val Leu Lys Trp Thr Tyr Arg Thr Leu Leu Thr Arg

180 185 190Ile Ala Ala His Asp Leu Ala Gly Thr Tyr Pro Thr Asp Met Arg Arg

195 200 205Lys Gly Gly Asp Pro Val Pro Phe Ser Thr Val Thr Met Gln Leu Ser

210 215 220Asp Leu Ala Asp Ala Ala Leu Thr Ala Ala Leu Ala Val Ala Ile Ala225 230 235 240Asn Val Tyr Gly Glu Lys Pro Val Asp Ser Ala Leu Ser Val Ile Ala

245 250 255Met Gly Lys Cys Gly Ala Gln Glu Leu Asn Tyr Ile Ser Asp Val Asp

260 265 270Val Val Phe Val Ala Glu Pro Ala Asn Ser Lys Ser Thr Arg Thr Ala

275 280 285Ala Glu Leu Ile Arg Ile Gly Ser Asn Ser Phe Phe Glu Val Asp Ala

290 295 300Ala Leu Arg Pro Glu Gly Lys Ser Gly Ala Leu Val Arg Ser Leu Asp305 310 315 320Ser His Met Ala Tyr Tyr Lys Arg Trp Ala Glu Thr Trp Glu Phe Gln

325 330 335Ala Leu Leu Lys Ala Arg Pro Met Thr Gly Asp Ile Asn Leu Gly Gln

340 345 350Ser Tyr Val Asp Ala Leu Ser Pro Leu Ile Trp Thr Ala Ser Gln Arg

355 360 365Glu Ser Phe Val Thr Asp Val Gln Ala Met Arg Arg Arg Val Leu Asp

370 375 380Asn Val Pro Glu Asp Leu Arg Asp Arg Glu Leu Lys Leu Gly Arg Gly385 390 395 400Gly Leu Arg Asp Val Glu Phe Ala Val Gln Leu Leu Gln Met Val His

405 410 415Gly Arg Ile Asp Glu Thr Leu Arg Val Arg Ser Thr Val Asn Ala Leu

420425 430His Val Leu Val Asp Gln Gly Tyr Val Gly Arg Glu Asp Gly His Asn

435 440 445Leu Ile Glu Ser Tyr Glu Phe Leu Arg Leu Leu Glu His Arg Leu Gln

450 455 460Leu Glu Arg Ile Lys Arg Thr His Leu Leu Pro Lys Pro Asp Asp Arg465 470 475 480Met Asn Met Arg Trp Leu Ala Arg Ala Ser Gly Phe Thr Gly Ser Met

485 490 495Glu Gln Ser Ser Ala Lys Ala Met Glu Arg His Leu Arg Lys Val Arg

500 505 510Leu Gln Ile Gln Ser Leu His Ser Gln Leu Phe Tyr Arg Pro Leu Leu

515 520 525Asn Ser Val Val Asn Leu Ser Ala Asp Ala Ile Arg Leu Ser Pro Asp

530 535 540Ala Ala Lys Leu Gln Leu Ala Ala Leu Gly Tyr Leu His Pro Ser Arg545 550 555 560Ala Tyr Glu His Leu Thr Ala Leu Ala Ser Gly Ala Ser Arg Lys Ala

565 570 575Lys Ile Gln Ala Met Leu Leu Pro Thr Leu Met Glu Trp Leu Ser Gln

580 585 590Thr Ala Glu Pro Asp Ala Gly Leu Leu Asn Tyr Arg Lys Leu Ser Asp

595 600 605Ala Ser Tyr Asp Arg Ser Trp Phe Leu Arg Met Leu Arg Asp Glu Gly

610 615 620Val Val Gly Gln Arg Leu Met Arg Ile Leu Gly Asn Ser Pro Tyr Ile625 630 635 640Ser Glu Leu Ile Ile Ser Thr Pro Asp Phe Met Lys Gln Leu Gly Asp

645650 655Ala Ala Ser Gly Pro Lys Leu Leu Ala Thr Ala Pro Thr Gln Val Val

660 665 670Lys Ala Ile Lys Ala Thr Val Ser Arg His Glu Ser Pro Asp Arg Ala

675 680 685Ile Gln Ala Ala Arg Ser Leu Arg Arg Gln Glu Leu Ala Arg Ile Ala

690 695 700Ser Ala Asp Leu Leu Asn Met Leu Thr Val Gln Glu Val Cys Gln Ser705 710 715 720Leu Ser Leu Val Trp Asp Ala Val Leu Asp Ala Ala Leu Asp Ala Glu

725 730 735Ile Arg Ala Ala Leu Asn Asp Pro Gln Lys Pro Asp Gln Pro Leu Ala

740 745 750Asn Ile Ser Val Ile Gly Met Gly Arg Leu Gly Gly Ala Glu Leu Gly

755 760 765Tyr Gly Ser Asp Ala Asp Val Met Phe Val Cys Glu Pro Val Ala Gly

770 775 780Val Glu Glu His Glu Ala Val Thr Trp Ser Ile Ala Ile Cys Asp Ser785 790 795 800Met Arg Ser Arg Leu Ala Gln Pro Ser Gly Asp Pro Pro Leu Glu Val

805 810 815Asp Leu Gly Leu Arg Pro Glu Gly Arg Ser Gly Ala Ile Val Arg Thr

820 825 830Val Asp Ser Tyr Val Lys Tyr Tyr Glu Lys Trp Gly Glu Thr Trp Glu

835 840 845Ile Gln Ala Leu Leu Arg Ala Ala Trp Val Ala Gly Asp Arg Glu Leu

850 855 860Gly Ile Lys Phe Leu Glu Ser Ile Asp Arg Phe Arg Tyr Pro Val Asp865 870 875 880Gly Ala Thr Gln Ala Gln Leu Arg Glu Val Arg Arg Ile Lys Ala Arg

885 890 895Val Asp Asn Glu Arg Leu Pro Arg Gly Ala Asp Arg Asn Thr His Thr

900 905 910Lys Leu Gly Arg Gly Ala Leu Thr Asp Ile Glu Trp Thr Val Gln Leu

915 920 925Leu Thr Met Met His Ala His Glu Ile Pro Glu Leu His Asn Thr Ser

930 935 940Thr Leu Glu Val Leu Glu Val Leu Glu Lys His Gln Ile Ile Asn Pro945 950 955 960Val Gln Val Gln Thr Leu Arg Glu Ala Trp Leu Thr Ala Thr Ala Ala

965 970 975Arg Asn Ala Leu Val Leu Val Arg Gly Lys Arg Leu Asp Gln Leu Pro

980 985 990Thr Pro Gly Pro His Leu Ala Gln Val Ala Gly Ala Ser Gly Trp Asp

995 1000 1005Pro Asn Glu Tyr Gln Glu Tyr Leu Glu Asn Tyr Leu Lys Val Thr Arg

1010 1015 1020Lys Ser Arg Gln Val Val Asp Glu Val Phe Trp Gly Val Asp Ser Met1025 1030 1035 1040Glu Gln Arg Glu Phe

1045<210>101<21l>861<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1).<861)<223>RXN03176<400>101gag ttg gcc gat tac atc ccg gaa cta aaa tct gcg gac cca aac ccg 48Glu Leu Ala Asp Tyr Ile Pro Glu Leu Lys Ser Ala Asp Pro Asn Pro 151015 ctg gca gta gcc ctg tgc acc gtt aac gga cac atc tac agc gca ggc 96Leu Ala Val Ala Leu Cys Thr Val Asn Gly His Ile Tyr Ser Ala Gly

2025 30gat gac gac atc gaa ttc acc atg caa agt att tcc aag cca ttt gcc 144Asp Asp Asp Ile Glu Phe Thr Met Gln Ser Ile Ser Lys Pro Phe Ala

35 40 45tac gca ctc gca ctc caa gaa tgc ggc ttt gat gag gtc tct gca tcc 192Tyr Ala Leu Ala Leu Gln Glu Cys Gly Phe Asp Glu Val Ser Ala Ser

50 55 60gtg gcc ttg gag ccc tcc ggt gag gcc ttc aac gaa ctt tcc ctc gac 240Val Ala Leu Glu Pro Ser Gly Glu Ala Phe Asn Glu Leu Ser Leu Asp 65 70 75 80ggc gaa aac cgc ccc atg aac ccc atg atc aac gcc ggc gcg atc gcc 288Gly Glu Asn Arg Pro Met Asn Pro Met Ile Asn Ala Gly Ala Ile Ala

85 90 95atc aac cag ctg atc aac ggc tcc gat tcc acc gtg gaa gac cgc gtg 336Ile Asn Gln Leu Ile Asn Gly Ser Asp Ser Thr Val Glu Asp Arg Val

100 105 110gaa aaa atc cga cac tac ttc tct gaa ctt gct gga cgc gaa ctc acc 384Glu Lys Ile Arg His Tyr Phe Ser Glu Leu Ala Gly Arg Glu Leu Thr

115 120 125atc gac cgc gtg ctt gcc gaa tcc gaa ctc gcc ggc gcc gac cgc aac 432Ile Asp Arg Val Leu Ala Glu Ser Glu Leu Ala Gly Ala Asp Arg Asn

130 135 140ctc tcc atc gcc cac atg ctg cgc aat tac ggc gtc atc gaa gac gaa 480Leu Ser Ile Ala His Met Leu Arg Asn Tyr Gly Val Ile Glu Asp Glu145 150 155 160gcc cac gac gcc gtc ctc agc tac acg ctg caa tgc gcc atc aaa gta 528Ala His Asp Ala Val Leu Ser Tyr Thr Leu Gln Cys Ala Ile Lys Val

165 170 175acc acg cgc gac ctc gca gtc atg acc gcc acg ctc gcc gcc ggc ggc 576Thr Thr Arg Asp Leu Ala Val Met Thr Ala Thr Leu Ala Ala Gly Gly

180 185 190aca cac cca att acc ggc aag aag ctt ctc gac gcc cgc gtc tgc cgc 624Thr His Pro Ile Thr Gly Lys Lys Leu Leu Asp Ala Arg Val Cys Arg

195 200 205ctc acc ctc tcc gtc atg gct tca gca ggc atg tac gac gag gca ggg 672Leu Thr Leu Ser Val Met Ala Ser Ala Gly Met Tyr Asp Glu Ala Gly

210 215 220cag tgg ctc tcc acc gta ggc atc ccc gcg aaa tca gga gtc gcc ggc 720Gln Trp Leu Ser Thr Val Gly Ile Pro Ala Lys Ser Gly Val Ala Gly225 230 235 240gga ctc atc ggc att ctg cca ggt cag ctg ggc atc gcc aca ttt tcc 768Gly Leu Ile Gly Ile Leu Pro Gly Gln Leu Gly Ile Ala Thr Phe Ser

245 250 255cca cgc ctg aac ccc aaa ggc aac agc gtg cgc ggc gta aaa ata ttc 816Pro Arg Leu Asn Pro Lys Gly Asn Ser Val Arg Gly Val Lys Ile Phe

260 265 270aaa cag ctt tcc gac gac atg ggc ctc cac ctc atg tcc acc gag 861Lys Gln Leu Ser Asp Asp Met Gly Leu His Leu Met Ser Thr Glu

275280285<210>102<211>287<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>102Glu Leu Ala Asp Tyr Ile Pro Glu Leu Lys Ser Ala Asp Pro Asn Pro 151015 Leu Ala Val Ala Leu Cys Thr Val Asn Gly His Ile Tyr Ser Ala Gly

20 25 30Asp Asp Asp Ile Glu Phe Thr Met Gln Ser Ile Ser Lys Pro Phe Ala

35 40 45Tyr Ala Leu Ala Leu Gln Glu Cys Gly Phe Asp Glu Val Ser Ala Ser

50 55 60Val Ala Leu Glu Pro Ser Gly Glu Ala Phe Asn Glu Leu Ser Leu Asp 65 70 75 80Gly Glu Asn Arg Pro Met Asn Pro Met Ile Asn Ala Gly Ala Ile Ala

85 90 95Ile Asn Gln Leu Ile Asn Gly Ser Asp Ser Thr Val Glu Asp Arg Val

100 105 110Glu Lys Ile Arg His Tyr Phe Ser Glu Leu Ala Gly Arg Glu Leu Thr

115 120 125Ile Asp Arg Val Leu Ala Glu Ser Glu Leu Ala Gly Ala Asp Arg Asn

130 135 140Leu Ser Ile Ala His Met Leu Arg Asn Tyr Gly Val Ile Glu Asp Glu145 150 155 160Ala His Asp Ala Val Leu Ser Tyr Thr Leu Gln Cys Ala Ile Lys Val

165 170 175Thr Thr Arg Asp Leu Ala Val Met Thr Ala Thr Leu Ala Ala Gly Gly

180 185 190Thr His Pro Ile Thr Gly Lys Lys Leu Leu Asp Ala Arg Val Cys Arg

195 200 205Leu Thr Leu Ser Val Met Ala Ser Ala Gly Met Tyr Asp Glu Ala Gly

210 215 220Gln Trp Leu Ser Thr Val Gly Ile Pro Ala Lys Ser Gly Val Ala Gly225 230 235 240Gly Leu Ile Gly Ile Leu Pro Gly Gln Leu Gly Ile Ala Thr Phe Ser

245 250 255Pro Arg Leu Asn Pro Lys Gly Asn Ser Val Arg Gly Val Lys Ile Phe

260 265 270Lys Gln Leu Ser Asp Asp Met Gly Leu His Leu Met Ser Thr Glu

275280285<210>103<211>861<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) } (861)<223>FRXA02879<400>103gag ttg gcc gat tac atc ccg gaa cta aaa tct gcg gac cca aac ccg 48Glu Leu Ala Asp Tyr Ile Pro Glu Leu Lys Ser Ala Asp Pro Asn Pro 151015 ctg gca gta gcc ctg tgc acc gtt aac gga cac atc tac agc gca ggc 96Leu Ala Val Ala Leu Cys Thr Val Asn Gly His Ile Tyr Ser Ala Gly

20 25 30gat gac gac atc gaa ttc acc atg caa agt att tcc aag cca ttt gcc 144Asp Asp Asp Ile Glu Phe Thr Met Gln Ser Ile Ser Lys Pro Phe Ala

35 40 45tac gca ctc gca ctc caa gaa tgc ggc ttt gat gag gtc tct gca tcc 192Tyr Ala Leu Ala Leu Gln Glu Cys Gly Phe Asp Glu Val Ser Ala Ser

50 55 60gtg gcc ttg gag ccc tcc ggt gag gcc ttc aac gaa ctt tcc ctc gac 240Val Ala Leu Glu Pro Ser Gly Glu Ala Phe Asn Glu Leu Ser Leu Asp 65 70 75 80ggc gaa aac cgc ccc atg aac ccc atg atc aac gcc ggc gcg atc gcc 288Gly Glu Asn Arg Pro Met Asn Pro Met Ile Asn Ala Gly Ala Ile Ala

85 90 95atc aac cag ctg atc aac ggc tcc gat tcc acc gtg gaa gac cgc gtg 336Ile Asn Gln Leu Ile Asn Gly Ser Asp Ser Thr Val Glu Asp Arg Val

100 105 110gaa aaa atc cga cac tac ttc tct gaa ctt gct gga cgc gaa ctc acc 384Glu Lys Ile Arg His Tyr Phe Ser Glu Leu Ala Gly Arg Glu Leu Thr

115 120 125atc gac cgc gtg ctt gcc gaa tcc gaa ctc gcc ggc gcc gac cgc aac 432Ile Asp Arg Val Leu Ala Glu Ser Glu Leu Ala Gly Ala Asp Arg Asn

130 135 140ctc tcc atc gcc cac atgctg cgc aat tac ggc gtc atc gaa gac gaa 480Leu Ser Ile Ala His Met Leu Arg Asn Tyr Gly Val Ile Glu Asp Glu145 150 155 160gcc cac gac gcc gtc ctc agc tac acg ctg caa tgc gcc atc aaa gta 528Ala His Asp Ala Val Leu Ser Tyr Thr Leu Gln Cys Ala Ile Lys Val

165 170 175acc acg cgc gac ctc gca gtc atg acc gcc acg ctc gcc gcc ggc ggc 576Thr Thr Arg Asp Leu Ala Val Met Thr Ala Thr Leu Ala Ala Gly Gly

180 185 190aca cac cca att acc ggc aag aag ctt ctc gac gcc cgc gtc tgc cgc 624Thr His Pro Ile Thr Gly Lys Lys Leu Leu Asp Ala Arg Val Cys Arg

195 200 205ctc acc ctc tcc gtc atg gct tca gca ggc atg tac gac gag gca ggg 672Leu Thr Leu Ser Val Met Ala Ser Ala Gly Met Tyr Asp Glu Ala Gly

210 215 220cag tgg ctc tcc acc gta ggc atc ccc gcg aaa tca gga gtc gcc ggc 720Gln Trp Leu Ser Thr Val Gly Ile Pro Ala Lys Ser Gly Val Ala Gly225 230 235 240gga ctc atc ggc att ctg cca ggt cag ctg ggc atc gcc aca ttt tcc 768Gly Leu Ile Gly Ile Leu Pro Gly Gln Leu Gly Ile Ala Thr Phe Ser

245 250 255cca cgc ctg aac ccc aaa ggc aac agc gtg cgc ggc gta aaa ata ttc 816Pro Arg Leu Asn Pro Lys Gly Asn Ser Val Arg Gly Val Lys Ile Phe

260 265 270aaa cag ctt tcc gac gac atg ggc ctc cac ctc atg tcc acc gag 861Lys Gln Leu Ser Asp Asp Met Gly Leu His Leu Met Ser Thr Glu

275280285<210>104<211>287<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>104Glu Leu Ala Asp Tyr Ile Pro Glu Leu Lys Ser AlaAsp Pro Asn Pro 151015 Leu Ala Val Ala Leu Cys Thr Val Asn Gly His Ile Tyr Ser Ala Gly

20 25 30Asp Asp Asp Ile Glu Phe Thr Met Gln Ser Ile Ser Lys Pro Phe Ala

35 40 45Tyr Ala Leu Ala Leu Gln Glu Cys Gly Phe Asp Glu Val Ser Ala Ser

50 55 60Val Ala Leu Glu Pro Ser Gly Glu Ala Phe Asn Glu Leu Ser Leu Asp 65 70 75 80Gly Glu Asn Arg Pro Met Asn Pro Met Ile Asn Ala Gly Ala Ile Ala

85 90 95Ile Asn Gln Leu Ile Asn Gly Ser Asp Ser Thr Val Glu Asp Arg Val

100 105 110Glu Lys Ile Arg His Tyr Phe Ser Glu Leu Ala Gly Arg Glu Leu Thr

115 120 125Ile Asp Arg Val Leu Ala Glu Ser Glu Leu Ala Gly Ala Asp Arg Asn

130 135 140Leu Ser Ile Ala His Met Leu Arg Asn Tyr Gly Val Ile Glu Asp Glu145 150 155 160Ala His Asp Ala Val Leu Ser Tyr Thr Leu Gln Cys Ala Ile Lys Val

165 170 175Thr Thr Arg Asp Leu Ala Val Met Thr Ala Thr Leu Ala Ala Gly Gly

180 185 190Thr His Pro Ile Thr Gly Lys Lys Leu Leu Asp Ala Arg Val Cys Arg

195 200 205Leu Thr Leu Ser Val Met Ala Ser Ala Gly Met Tyr Asp Glu Ala Gly

210 215 220Gln Trp Leu Ser Thr Val Gly Ile Pro Ala Lys Ser Gly Val Ala Gly225 230 235 240Gly Leu Ile Gly Ile Leu Pro Gly Gln Leu Gly Ile Ala Thr Phe Ser

245 250 255Pro Arg Leu Asn Pro Lys Gly Asn Ser Val Arg Gly Val Lys Ile Phe

260 265 270Lys Gln Leu Ser Asp Asp Met Gly Leu His Leu Met Ser Thr Glu

275280285<210>105<211>1155<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1132)<223>RXA00278<400>105ggccacggag ttggtgtccg tcatggtgat gattctgtct gtcgtttctg tgttggcttt 60gtgggtcggc atccgccccc gtttgcagga gtacttataa atg cac gct ttt cga 115

Met His Ala Phe Arg

1 5cgc ccc cct cca ctc acc acg cga gtc ggc gct gca ttg ctg gcc gca 163Arg Pro Pro Pro Leu Thr Thr Arg Val Gly Ala Ala Leu Leu Ala Ala

10 15 20acg ctg ctt gct tcc tgc act cca aca cct gtg gaa ccg gca gaa acc 211Thr Leu Leu Ala Ser Cys Thr Pro Thr Pro Val Glu Pro Ala Glu Thr

25 30 35ttg act gct ttg gat ccc gat gcc ggt cca cca ctg cca ccg gat tct 259Leu Thr Ala Leu Asp Pro Asp Ala Gly Pro Pro Leu Pro Pro Asp Ser

40 45 50tcg att gaa gct ccc ggt gaa aaa gag ccc att gtg gaa gta ata gag 307Ser Ile Glu Ala Pro Gly Glu Lys Glu Pro Ile Val Glu Val Ile Glu

55 60 65aat tgg cca ggt tct tta cgc ccg gat gat ctg acc cct gag gag cgg 355Asn Trp Pro Gly Ser Leu Arg Pro Asp Asp Leu Thr Pro Glu Glu Arg 70 75 80 85gta cct ggc atc gtcaac cgg ggt cgc atc att gtg ggt gtg gat caa 403Val Pro Gly Ile Val Asn Arg Gly Arg Ile Ile Val Gly Val Asp Gln

90 95 100tcg caa aac ttg ctc agt ttc cgt gat ccg gtg act ggt gag ctg cgc 451Ser Gln Asn Leu Leu Ser Phe Arg Asp Pro Val Thr Gly Glu Leu Arg

105 110 115ggt ttt gaa gtg gaa tta gcg agg gaa att tcc cgc gac att ttc ggt 499Gly Phe Glu Val Glu Leu Ala Arg Glu Ile Ser Arg Asp Ile Phe Gly

120 125 130gac ccc aat aag gtg gat ttc cga ttc gtc ggc tcg tcc gac cgt ctg 547Asp Pro Asn Lys Val Asp Phe Arg Phe Val Gly Ser Ser Asp Arg Leu

135 140 145cgt tcc ctt gac caa ggt gat gta gat att gtg att cgt tcc gtc acg 595Arg Ser Leu Asp Gln Gly Asp Val Asp Ile Val Ile Arg Ser Val Thr150 155 160 165atc acc gac gaa cgc gcc aaa ttg gtg gaa ttt tcc aca ccg tac ctg 643Ile Thr Asp Glu Arg Ala Lys Leu Val Glu Phe Ser Thr Pro Tyr Leu

170 175 180cgc acc caa acc cgc atg ttg acc atg gaa tct tca gga atc acg tcc 691Arg Thr Gln Thr Arg Met Leu Thr Met Glu Ser Ser Gly Ile Thr Ser

185 190 195atc gca gat cta ccc ggc cac acc att tgt gtc acc gat ggc tcc act 739Ile Ala Asp Leu Pro Gly His Thr Ile Cys Val Thr Asp Gly Ser Thr

200 205 210tca ttg cag cga gcc cgc acc att gcg ccg gag gcc tca atc tta aaa 787Ser Leu Gln Arg Ala Arg Thr Ile Ala Pro Glu Ala Ser Ile Leu Lys

215 220 225act cgc aat tgg tcc gat tgt ctc atg gcg ttg cag cag cat cag gct 835Thr Arg Asn Trp Ser Asp Cys Leu MetAla Leu Gln Gln His Gln Ala230 235 240 245cag gtc att ttg ggc gat gat gtc att ttg tcc ggc atc gca gca cag 883Gln Val Ile Leu Gly Asp Asp Val Ile Leu Ser Gly Ile Ala Ala Gln

250 255 260gat ccc tac acc gag att ctt gat acc tcc ctc gat tcc cat tcc tat 931Asp Pro Tyr Thr Glu Ile Leu Asp Thr Ser Leu Asp Ser His Ser Tyr

265 270 275gga gtg gca gcg gca tcg acc act gct gaa aca gac tct tcg ggg ttg 979Gly Val Ala Ala Ala Ser Thr Thr Ala Glu Thr Asp Ser Ser Gly Leu

280 285 290att cgg cag gta aac tac aca att gaa cgg atc cgc aca gac cgc atg 1027Ile Arg Gln Val Asn Tyr Thr Ile Glu Arg Ile Arg Thr Asp Arg Met

295 300 305tgg tgg aca atg ttc gac gat tgg ttc gga cct tat ctc tgg tcc tac 1075Trp Trp Thr Met Phe Asp Asp Trp Phe Gly Pro Tyr Leu Trp Ser Tyr310 315 320 325ggt cca cca cag ctg cag tac atg cca gag gaa gaa ggg aca gaa aac 1123Gly Pro Pro Gln Leu Gln Tyr Met Pro Glu Glu Glu Gly Thr Glu Asn

330335340 gat gaa gga taatgaagat ttcgatccag att 1155Asp Glu Gly<210>106<211>344<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>106Met His Ala Phe Arg Arg Pro Pro Pro Leu Thr Thr Arg Val Gly Ala 151015 Ala Leu Leu Ala Ala Thr Leu Leu Ala Ser Cys Thr Pro Thr Pro Val

20 25 30Glu Pro Ala Glu Thr Leu Thr Ala Leu Asp Pro Asp Ala Gly Pro Pro

35 40 45Leu Pro Pro Asp Ser Ser Ile Glu Ala Pro Gly Glu Lys Glu Pro Ile

50 5560Val Glu Val Ile Glu Asn Trp Pro Gly Ser Leu Arg Pro Asp Asp Leu 65 70 75 80Thr Pro Glu Glu Arg Val Pro Gly Ile Val Asn Arg Gly Arg Ile Ile

85 90 95Val Gly Val Asp Gln Ser Gln Asn Leu Leu Ser Phe Arg Asp Pro Val

100 105 110Thr Gly Glu Leu Arg Gly Phe Glu Val Glu Leu Ala Arg Glu Ile Ser

115 120 125Arg Asp Ile Phe Gly Asp Pro Asn Lys Val Asp Phe Arg Phe Val Gly

130 135 140Ser Ser Asp Arg Leu Arg Ser Leu Asp Gln Gly Asp Val Asp Ile Val145 150 155 160Ile Arg Ser Val Thr Ile Thr Asp Glu Arg Ala Lys Leu Val Glu Phe

165 170 175Ser Thr Pro Tyr Leu Arg Thr Gln Thr Arg Met Leu Thr Met Glu Ser

180 185 190Ser Gly Ile Thr Ser Ile Ala Asp Leu Pro Gly His Thr Ile Cys Val

195 200 205Thr Asp Gly Ser Thr Ser Leu Gln Arg Ala Arg Thr Ile Ala Pro Glu

210 215 220Ala Ser Ile Leu Lys Thr Arg Asn Trp Ser Asp Cys Leu Met Ala Leu225 230 235 240Gln Gln His Gln Ala Gln Val Ile Leu Gly Asp Asp Val Ile Leu Ser

245 250 255Gly Ile Ala Ala Gln Asp Pro Tyr Thr Glu Ile Leu Asp Thr Ser Leu

260 265 270Asp Ser His Ser Tyr Gly Val Ala Ala Ala Ser Thr Thr Ala Glu Thr

275 280 285Asp SerSer Gly Leu Ile Arg Gln Val Asn Tyr Thr Ile Glu Arg Ile

290 295 300Arg Thr Asp Arg Met Trp Trp Thr Met Phe Asp Asp Trp Phe Gly Pro305 310 315 320Tyr Leu Trp Ser Tyr Gly Pro Pro Gln Leu Gln Tyr Met Pro Glu Glu

325 330 335Glu Gly Thr Glu Asn Asp Glu Gly

340<210>107<211>1035<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1012)<223>RXA00727<400>107ttattgcacc atggcaggta gtattttgcc catgattgag agtttcaccc gattgcgaat 60ttcgcagaca ccgcctctga aacggctact gcatagcact ttg cgt ttc ccc aaa 115

Leu Arg Phe Pro Lys

1 5atc ccc aag cgc gct gta gcg gcg acc gtc ggc atc gtg gca acc tca 163Ile Pro Lys Arg Ala Val Ala Ala Thr Val Gly Ile Val Ala Thr Ser

10 15 20ttc acc ttg gct tct tgt gtc acc aat gag gag cag ggc aac cca gat 211Phe Thr Leu Ala Ser Cys Val Thr Asn Glu Glu Gln Gly Asn Pro Asp

25 30 35ggc tgg gag cag atc gtt cca gat cct gta ccg gag att cag gcg atg 259Gly Trp Glu Gln Ile Val Pro Asp Pro Val Pro Glu Ile Gln Ala Met

40 45 50gtt ccc gaa gct ctg gct cag cgc ggt gtg ctc acc gcc ggt gcc aac 307Val Pro Glu Ala Leu Ala Gln Arg Gly Val Leu Thr Ala Gly Ala Asn

55 60 65cca cct ttc cca ccg ttt gag ttt aaa gat tcc gat ggt cag att atc 355Pro Pro Phe Pro Pro Phe Glu Phe Lys Asp Ser Asp Gly Gln Ile Ile 7075 80 85ggt gtg gaa atg gac ctc gtg cgt gca atg gcg ggg gtg atg ggc ttg 403Gly Val Glu Met Asp Leu Val Arg Ala Met Ala Gly Val Met Gly Leu

90 95 100gag ttc agc cct cag gag cag gat ttc tcc ctc atc ctt cca tcg gtt 451Glu Phe Ser Pro Gln Glu Gln Asp Phe Ser Leu Ile Leu Pro Ser Val

105 110 115caa gct ggc acc ctt gat atc gga gcc tct ggc ttc act gac aac gag 499Gln Ala Gly Thr Leu Asp Ile Gly Ala Ser Gly Phe Thr Asp Asn Glu

120 125 130gaa cgc cgc gag aac ttt gat ttc atc gat ttc ctc ttc gca ggt gtg 547Glu Arg Arg Glu Asn Phe Asp Phe Ile Asp Phe Leu Phe Ala Gly Val

135 140 145cag tgg gcg cag gca act gat cgt gaa acc cca atc gat ccg gaa aac 595Gln Trp Ala Gln Ala Thr Asp Arg Glu Thr Pro Ile Asp Pro Glu Asn150 155 160 165gcc tgt ggt ctc acc gtt gct gta cag cgc aca acc gtg gca gag acc 643Ala Cys Gly Leu Thr Val Ala Val Gln Arg Thr Thr Val Ala Glu Thr

170 175 180gac gat gtc cgt cct cgc tca gct caa tgt gaa gcc gaa ggc aaa gag 691Asp Asp Val Arg Pro Arg Ser Ala Gln Cys Glu Ala Glu Gly Lys Glu

185 190 195ccg atc acc att ttg tct tat gaa acc gca gat act gca gct acc gca 739Pro Ile Thr Ile Leu Ser Tyr Glu Thr Ala Asp Thr Ala Ala Thr Ala

200 205 210ttg atc ctg gga cgc gca gac gca ctt gct gcg gac tcc cct gtt tca 787Leu Ile Leu Gly Arg Ala Asp Ala Leu Ala Ala Asp Ser Pro Val Ser

215 220 225gct tgg gct gca gag cgc tcc gaa ggccgc atc gaa gtt gtg ggc gat 835Ala Trp Ala Ala Glu Arg Ser Glu Gly Arg Ile Glu Val Val Gly Asp230 235 240 245atg tac ttg gct gcg cca ttt ggt ttc gca ttc ccg ttg gaa tct gac 883Met Tyr Leu Ala Ala Pro Phe Gly Phe Ala Phe Pro Leu Glu Ser Asp

250 255 260ctc acc cca gca gca gct gcg gcg ttc caa cac ttg att gac acc ggc 931Leu Thr Pro Ala Ala Ala Ala Ala Phe Gln His Leu Ile Asp Thr Gly

265 270 275gat tac cag cgc atc atg gcg caa tgg ggc att gaa gaa ggc ctt ctt 979Asp Tyr Gln Arg Ile Met Ala Gln Trp Gly Ile Glu Glu Gly Leu Leu

280 285 290gat gag gcc ctg atc aac gaa cag cca ctc aac tagagccttc cagcaactaa 1032Asp Glu Ala Leu Ile Asn Glu Gln Pro Leu Asn

295300 aaa 1035<210>108<211>304<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>108Leu Arg Phe Pro Lys Ile Pro Lys Arg Ala Val Ala Ala Thr Val Gly 151015 Ile Val Ala Thr Ser Phe Thr Leu Ala Ser Cys Val Thr Asn Glu Glu

20 25 30Gln Gly Asn Pro Asp Gly Trp Glu Gln Ile Val Pro Asp Pro Val Pro

35 40 45Glu Ile Gln Ala Met Val Pro Glu Ala Leu Ala Gln Arg Gly Val Leu

50 55 60Thr Ala Gly Ala Asn Pro Pro Phe Pro Pro Phe Glu Phe Lys Asp Ser 65 70 75 80Asp Gly Gln Ile Ile Gly Val Glu Met Asp Leu Val Arg Ala Met Ala

85 90 95Gly Val Met Gly Leu Glu Phe Ser Pro Gln Glu Gln Asp Phe Ser Leu

100105 110Ile Leu Pro Ser Val Gln Ala Gly Thr Leu Asp Ile Gly Ala Ser Gly

115 120 125Phe Thr Asp Asn Glu Glu Arg Arg Glu Asn Phe Asp Phe Ile Asp Phe

130 135 140Leu Phe Ala Gly Val Gln Trp Ala Gln Ala Thr Asp Arg Glu Thr Pro145 150 155 160Ile Asp Pro Glu Asn Ala Cys Gly Leu Thr Val Ala Val Gln Arg Thr

165 170 175Thr Val Ala Glu Thr Asp Asp Val Arg Pro Arg Ser Ala Gln Cys Glu

180 185 190Ala Glu Gly Lys Glu Pro Ile Thr Ile Leu Ser Tyr Glu Thr Ala Asp

195 200 205Thr Ala Ala Thr Ala Leu Ile Leu Gly Arg Ala Asp Ala Leu Ala Ala

210 215 220Asp Ser Pro Val Ser Ala Trp Ala Ala Glu Arg Ser Glu Gly Arg Ile225 230 235 240Glu Val Val Gly Asp Met Tyr Leu Ala Ala Pro Phe Gly Phe Ala Phe

245 250 255Pro Leu Glu Ser Asp Leu Thr Pro Ala Ala Ala Ala Ala Phe Gln His

260 265 270Leu Ile Asp Thr Gly Asp Tyr Gln Arg Ile Met Ala Gln Trp Gly Ile

275 280 285Glu Glu Gly Leu Leu Asp Glu Ala Leu Ile Asn Glu Gln Pro Leu Asn

290295300<210>109<211>1962<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1939)<223>RXA02139<400>109tcaggaggat ttttcaatca tgtgcggcct tcttggcata ttgactgcaa atgggaacgc 60tgaagcattc gttcctgcac tcgagcgggc cttgccatgc atg cgc cac cgt ggt 115

Met Arg His Arg Gly

1 5cct gac gat gcc ggc act tgg cat gac gcc gat gca gcg ttt gga ttc 163Pro Asp Asp Ala Gly Thr Trp His Asp Ala Asp Ala Ala Phe Gly Phe

10 15 20aac cgc ctc tcc atc att gat att gca cac tcc cac caa cca ctg cgt 211Asn Arg Leu Ser Ile Ile Asp Ile Ala His Ser His Gln Pro Leu Arg

25 30 35tgg gga cct gcg gat gaa ccc gac cgc tac gca atg act ttc aac ggt 259Trp Gly Pro Ala Asp Glu Pro Asp Arg Tyr Ala Met Thr Phe Asn Gly

40 45 50gag atc tac aac tac gtt gag ctg cgt aaa gag ctc tcg gat ttg gga 307Glu Ile Tyr Asn Tyr Val Glu Leu Arg Lys Glu Leu Ser Asp Leu Gly

55 60 65tat gcc ttt aat act tct ggc gat ggc gag cca att gtt gtc ggt ttc 355Tyr Ala Phe Asn Thr Ser Gly Asp Gly Glu Pro Ile Val Val Gly Phe 70 75 80 85cac cac tgg ggc gag tcc gtg gtc gag cat ctc cgc gga atg ttc ggc 403His His Trp Gly Glu Ser Val Val Glu His Leu Arg Gly Met Phe Gly

90 95 100att gcc att tgg gat aca aag gaa aag tcg ctt ttc ctt gcg cgt gat 451Ile Ala Ile Trp Asp Thr Lys Glu Lys Ser Leu Phe Leu Ala Arg Asp

105 110 115cag ttc ggc att aag cca ctg ttc tac gca acc acc gag cat ggc acc 499Gln Phe Gly Ile Lys Pro Leu Phe Tyr Ala Thr Thr Glu His Gly Thr

120 125 130gtg ttc tcc tca gag aag aag acc atc ttg gag atg gcc gag gag atg 547ValPhe Ser Ser Glu Lys Lys Thr Ile Leu Glu Met Ala Glu Glu Met

135 140 145aat cta gat ctg ggc ctt gat aag cgc acc att gag cac tac gtg gac 595Asn Leu Asp Leu Gly Leu Asp Lys Arg Thr Ile Glu His Tyr Val Asp150 155 160 165ttg cag tac gtg ccc gag cca gat acc ctt cac gcg cag att tcc cgc 643Leu Gln Tyr Val Pro Glu Pro Asp Thr Leu His Ala Gln Ile Ser Arg

170 175 180ttg gag tca ggc tgc acc gca aca gtt cgt ccg ggc ggc aag ctg gaa 691Leu Glu Ser Gly Cys Thr Ala Thr Val Arg Pro Gly Gly Lys Leu Glu

185 190 195cag aag cgt tac ttc aag cct cag ttc cca gta cag aag gtc gta aag 739Gln Lys Arg Tyr Phe Lys Pro Gln Phe Pro Val Gln Lys Val Val Lys

200 205 210ggt aag gag cag gac ctc ttc gat cgc att gcc cag gtg ttg gag gat 787Gly Lys Glu Gln Asp Leu Phe Asp Arg Ile Ala Gln Val Leu Glu Asp

215 220 225agc gtc gaa aag cat atg cgt gcc gac gtg acc gta ggc tcg ttc ctt 835Ser Val Glu Lys His Met Arg Ala Asp Val Thr Val Gly Ser Phe Leu230 235 240 245ttc ggc ggc att gac tca acc gca att gcg gcg ctt gca aag cgc cac 883Phe Gly Gly Ile Asp Set Thr Ala Ile Ala Ala Leu Ala Lys Arg His

250 255 260aac cct gac ctg ctc acc ttc acc acc ggt ttc gag cgt gaa ggc tac 931Asn Pro Asp Leu Leu Thr Phe Thr Thr Gly Phe Glu Arg Glu Gly Tyr

265 270 275tcg gag gtc gat gtg gct gcg gag tcc gcc gct gcg att ggc gct gag 979Ser Glu Val Asp Val Ala Ala Glu Ser Ala Ala Ala Ile Gly Ala Glu

280285 290cac atc gtg aag att gtc tcg cct gag gaa tac gcc aac gcg att cct 1027His Ile Val Lys Ile Val Ser Pro Glu Glu Tyr Ala Asn Ala Ile Pro

295 300 305aag atc atg tgg tac ttg gat gat cct gta gct gac cca tca ttg gtc 1075Lys Ile Met Trp Tyr Leu Asp Asp Pro Val Ala Asp Pro Ser Leu Val310 315 320 325ccg ctg tac ttc gtg gca gcg gaa gca cgt aag cac gtc aag gtt gtg 1123Pro Leu Tyr Phe Val Ala Ala Glu Ala Arg Lys His Val Lys Val Val

330 335 340ctg tct ggc gag ggc gca gat gag ctg ttc ggt gga tac acc att tac 1171Leu Ser Gly Glu Gly Ala Asp Glu Leu Phe Gly Gly Tyr Thr Ile Tyr

345 350 355aag gag ccg cta tcg ctt gct cca ttt gag aag atc cct tcc cca cta 1219Lys Glu Pro Leu Ser Leu Ala Pro Phe Glu Lys Ile Pro Ser Pro Leu

360 365 370cgt aaa ggc ctg gga aag ctc agc aag gtt ctg cca gac ggc atg aag 1267Arg Lys Gly Leu Gly Lys Leu Ser Lys Val Leu Pro Asp Gly Met Lys

375 380 385ggc aag tcc ctt ctt gag cgt ggc tcc atg acc atg gaa gag cgc tac 1315Gly Lys Ser Leu Leu Glu Arg Gly Ser Met Thr Met Glu Glu Arg Tyr390 395 400 405tac ggc aac gct cgc tcc ttc aat ttc gag cag atg caa cgc gtt att 1363Tyr Gly Asn Ala Arg Ser Phe Asn Phe Glu Gln Met Gln Arg Val Ile

410 415 420cca tgg gca aag cgc gaa tgg gac cac cgc gaa gtc act gcg ccg atc 1411Pro Trp Ala Lys Arg Glu Trp Asp His Arg Glu Val Thr Ala Pro Ile

425 430 435tac gca cag tcc cgc aac ttt gat cca gta gcc cgc atg caa cac ctg 1459Tyr Ala Gln Ser Arg Asn Phe Asp Pro Val Ala Arg Met Gln His Leu

440 445 450gat ctg ttc acc tgg atg cgc ggc gac atc ctg gtc aag gct gac aag 1507Asp Leu Phe Thr Trp Met Arg Gly Asp Ile Leu Val Lys Ala Asp Lys

455 460 465atc aac atg gcg aac tcc ctt gag ctg cga gtt cca ttc ttg gat aag 1555Ile Asn Met Ala Asn Ser Leu Glu Leu Arg Val Pro Phe Leu Asp Lys470 475 480 485gaa gtt ttc aag gtt gca gag acc att cct tac gac ctg aag att gcc 1603Glu Val Phe Lys Val Ala Glu Thr Ile Pro Tyr Asp Leu Lys Ile Ala

490 495 500aac ggt acc acc aag tac gcg ctg cgc agg gca ctc gag cag att gtt 1651Asn Gly Thr Thr Lys Tyr Ala Leu Arg Arg Ala Leu Glu Gln Ile Val

505 510 515ccg cct cac gtt ttg cac cgc aag aag ctg ggc ttc cct gtt ccc atg 1699Pro Pro His Val Leu His Arg Lys Lys Leu Gly Phe Pro Val Pro Met

520 525 530cgc cac tgg ctt gcc ggc gat gag ctg ttc ggt tgg gcg cag gac acc 1747Arg His Trp Leu Ala Gly Asp Glu Leu Phe Gly Trp Ala Gln Asp Thr

535 540 545atc aag gaa tcc ggt act gaa gat atc ttc aac aag cag gct gtg ctg 1795Ile Lys Glu Ser Gly Thr Glu Asp Ile Phe Asn Lys Gln Ala Val Leu550 555 560 565gat atg ctg aac gag cac cgc gat ggc gtg tca gat cat tcc cgt cga 1843Asp Met Leu Asn Glu His Arg Asp Gly Val Ser Asp His Ser Arg Arg

570 575 580ctg tgg act gtt ctg tca ttt atg gtg tgg cac ggc att ttt gtg gaa 1891Leu Trp Thr Val Leu Ser Phe Met Val Trp His Gly Ile Phe Val Glu

585 590595aac cgc att gat cca cag att gag gac cgc tcc tac cca gtc gag ctt 1939Asn Arg Ile Asp Pro Gln Ile Glu Asp Arg Ser Tyr Pro Val Glu Leu

600605610 taagtcttaa agcctaaacc ccc 1962<210>110<211>613<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>110Met Arg His Arg Gly Pro Asp Asp Ala Gly Thr Trp His Asp Ala Asp 151015 Ala Ala Phe Gly Phe Asn Arg Leu Ser Ile Ile Asp Ile Ala His Ser

20 25 30His Gln Pro Leu Arg Trp Gly Pro Ala Asp Glu Pro Asp Arg Tyr Ala

35 40 45Met Thr Phe Asn Gly Glu Ile Tyr Asn Tyr Val Glu Leu Arg Lys Glu

50 55 60Leu Ser Asp Leu Gly Tyr Ala Phe Asn Thr Ser Gly Asp Gly Glu Pro 65 70 75 80Ile Val Val Gly Phe His His Trp Gly Glu Ser Val Val Glu His Leu

85 90 95Arg Gly Met Phe Gly Ile Ala Ile Trp Asp Thr Lys Glu Lys Ser Leu

100 105 110Phe Leu Ala Arg Asp Gln Phe Gly Ile Lys Pro Leu Phe Tyr Ala Thr

115 120 125Thr Glu His Gly Thr Val Phe Ser Ser Glu Lys Lys Thr Ile Leu Glu

130 135 140Met Ala Glu Glu Met Asn Leu Asp Leu Gly Leu Asp Lys Arg Thr Ile145 150 155 160Glu His Tyr Val Asp Leu Gln Tyr Val Pro Glu Pro Asp Thr Leu His

165 170 175Ala Gln Ile Ser Arg Leu Glu Ser Gly Cys Thr Ala Thr Val Arg Pro

180 185 190Gly Gly Lys LeuGlu Gln Lys Arg Tyr Phe Lys Pro Gln Phe Pro Val

195 200 205Gln Lys Val Val Lys Gly Lys Glu Gln Asp Leu Phe Asp Arg Ile Ala

210 215 220Gln Val Leu Glu Asp Ser Val Glu Lys His Met Arg Ala Asp Val Thr225 230 235 240Val Gly Ser Phe Leu Phe Gly Gly Ile Asp Ser Thr Ala Ile Ala Ala

245 250 255Leu Ala Lys Arg His Asn Pro Asp Leu Leu Thr Phe Thr Thr Gly Phe

260 265 270Glu Arg Glu Gly Tyr Ser Glu Val Asp Val Ala Ala Glu Ser Ala Ala

275 280 285Ala Ile Gly Ala Glu His Ile Val Lys Ile Val Ser Pro Glu Glu Tyr

290 295 300Ala Asn Ala Ile Pro Lys Ile Met Trp Tyr Leu Asp Asp Pro Val Ala305 310 315 320Asp Pro Ser Leu Val Pro Leu Tyr Phe Val Ala Ala Glu Ala Arg Lys

325 330 335His Val Lys Val Val Leu Ser Gly Glu Gly Ala Asp Glu Leu Phe Gly

340 345 350Gly Tyr Thr Ile Tyr Lys Glu Pro Leu Ser Leu Ala Pro Phe Glu Lys

355 360 365Ile Pro Ser Pro Leu Arg Lys Gly Leu Gly Lys Leu Ser Lys Val Leu

370 375 380Pro Asp Gly Met Lys Gly Lys Ser Leu Leu Glu Arg Gly Ser Met Thr385 390 395 400Met Glu Glu Arg Tyr Tyr Gly Asn Ala Arg Ser Phe Asn Phe Glu Gln

405 410 415Met Gln Arg Val Ile Pro Trp Ala LysArg Glu Trp Asp His Arg Glu

420 425 430Val Thr Ala Pro Ile Tyr Ala Gln Ser Arg Asn Phe Asp Pro Val Ala

435 440 445Arg Met Gln His Leu Asp Leu Phe Thr Trp Met Arg Gly Asp Ile Leu

450 455 460Val Lys Ala Asp Lys Ile Asn Met Ala Asn Ser Leu Glu Leu Arg Val465 470 475 480Pro Phe Leu Asp Lys Glu Val Phe Lys Val Ala Glu Thr Ile Pro Tyr

485 490 495Asp Leu Lys Ile Ala Asn Gly Thr Thr Lys Tyr Ala Leu Arg Arg Ala

500 505 510Leu Glu Gln Ile Val Pro Pro His Val Leu His Arg Lys Lys Leu Gly

515 520 525Phe Pro Val Pro Met Arg His Trp Leu Ala Gly Asp Glu Leu Phe Gly

530 535 540Trp Ala Gln Asp Thr Ile Lys Glu Ser Gly Thr Glu Asp Ile Phe Asn545 550 555 560Lys Gln Ala Val Leu Asp Met Leu Asn Glu His Arg Asp Gly Val Ser

565 570 575Asp His Ser Arg Arg Leu Trp Thr Val Leu Ser Phe Met Val Trp His

580 585 590Gly Ile Phe Val Glu Asn Arg Ile Asp Pro Gln Ile Glu Asp Arg Ser

595 600 605Tyr Pro Val Glu Leu

610<210>111<211>1284<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1261)<223>RXN 00116<400>111cgcggcacgc acgctggggg caagcgtcga caagcacaaa ctttttgctt aattgaatcc 60tttgcgcacc aatcaatggg ggatcaaata tagtagctgc atg agt aat gac ttc 115

Met Ser Asn Asp Phe

1 5gtc gtt tct agg ctt aga ccc ttt ggt gaa acg att ttt gca acc atg 163Val Val Ser Arg Leu Arg Pro Phe Gly Glu Thr Ile Phe Ala Thr Met

10 15 20acc cag cga gct gtt gag gcg ggt gca atc aat ctt ggt cag ggc ttt 211Thr Gln Arg Ala Val Glu Ala Gly Ala Ile Asn Leu Gly Gln Gly Phe

25 30 35cct gat gag gat ggt cct cgt cgg atg tta gag atc gcg tcg gag cag 259Pro Asp Glu Asp Gly Pro Arg Arg Met Leu Glu Ile Ala Ser Glu Gln

40 45 50att ctc ggg gga aat aat cag tat tcg gcg ggg cgt ggg gat gct tcg 307Ile Leu Gly Gly Asn Asn Gln Tyr Ser Ala Gly Arg Gly Asp Ala Ser

55 60 65ttg agg gca gct gtg gct cgt gat cat ttg gag agg ttt gat ctg gag 355Leu Arg Ala Ala Val Ala Arg Asp His Leu Glu Arg Phe Asp Leu Glu 70 75 80 85tac aac cct gat tcg gag gtg ttg atc acg gtg ggg gcc act gag gcg 403Tyr Asn Pro Asp Ser Glu Val Leu Ile Thr Val Gly Ala Thr Glu Ala

90 95 100att acg gcg act gtg ttg ggt ttg gtg gag cct ggg gat gaa gtg atc 451Ile Thr Ala Thr Val Leu Gly Leu Val Glu Pro Gly Asp Glu Val Ile

105 110 115gtt ttg gaa ccg tat tac gat gcg tat gcg gcg gct att gcg ttg gcg 499Val Leu Glu Pro Tyr Tyr Asp Ala Tyr Ala Ala Ala Ile Ala Leu Ala

120 125 130ggg gcg acg cgg gtg gcg gtt cct ttg caggag gtg gag aac tcg tgg 547Gly Ala Thr Arg Val Ala Val Pro Leu Gln Glu Val Glu Asn Ser Trp

135 140 145gat gtg gat gtc gat aag ttg cat gcg gcg gtg act aag aag acg cgg 595Asp Val Asp Val Asp Lys Leu His Ala Ala Val Thr Lys Lys Thr Arg150 155 160 165atg att atc gtt aat tcg ccg cat aat ccg acg ggt tcg gtg ttt tct 643Met Ile Ile Val Asn Ser Pro His Asn Pro Thr Gly Ser Val Phe Ser

170 175 180aag aag gcg ttg aag cag ttg gcg ggt gtt gct cgt gcg tat gac ttg 691Lys Lys Ala Leu Lys Gln Leu Ala Gly Val Ala Arg Ala Tyr Asp Leu

185 190 195ttg gtg ttg tca gat gag gtg tat gag cat ctt gtt ttt gat gat cag 739Leu Val Leu Ser Asp Glu Val Tyr Glu His Leu Val Phe Asp Asp Gln

200 205 210aag cat gtg agt gtc gcg aag ctg ccc ggt atg tgg gat cgc acg gtg 787Lys His Val Ser Val Ala Lys Leu Pro Gly Met Trp Asp Arg Thr Val

215 220 225acg gtg tcg tcg gcg gcg aaa acg ttc aat gtg act ggt tgg aag acg 835Thr Val Ser Ser Ala Ala Lys Thr Phe Asn Val Thr Gly Trp Lys Thr230 235 240 245ggg tgg gcg ttg gca ccg gag ccg ttg ttg gag gcg gtg ttg aag gcg 883Gly Trp Ala Leu Ala Pro Glu Pro Leu Leu Glu Ala Val Leu Lys Ala

250 255 260aag cag ttt atg tct tat gtg ggg gct aca cct ttt cag ccg gct gtg 931Lys Gln Phe Met Ser Tyr Val Gly Ala Thr Pro Phe Gln Pro Ala Val

265 270 275gcg cat gcg att gaa cat gag cag aag tgg gtg tca aag atg tct aag 979Ala His Ala Ile Glu His Glu Gln Lys Trp Val Ser Lys Met Ser Lys

280 285 290ggg ctt gag ctc aag cgg gat att ttg cgt act gcg tta gat aag gcg 1027Gly Leu Glu Leu Lys Arg Asp Ile Leu Arg Thr Ala Leu Asp Lys Ala

295 300 305ggg ctg aag act cat gac agt atg ggc acg tat ttc atc gtt gcg gat 1075Gly Leu Lys Thr His Asp Ser Met Gly Thr Tyr Phe Ile Val Ala Asp310 315 320 325att ggg gat cgt gat ggt gcg gag ttc tgt ttt gag ttg att gag aag 1123Ile Gly Asp Arg Asp Gly Ala Glu Phe Cys Phe Glu Leu Ile Glu Lys

330 335 340gtt ggg gtg gcg gcg att ccg gtg cag gcg ttt gtg gat cat ccg aag 1171Val Gly Val Ala Ala Ile Pro Val Gln Ala Phe Val Asp His Pro Lys

345 350 355aag tgg tcg tcg aag gtt cgt ttt gcg ttt tgc aaa aaa gaa gag acg 1219Lys Trp Ser Ser Lys Val Arg Phe Ala Phe Cys Lys Lys Glu Glu Thr

360 365 370ctc cgc gaa gct gcg gag cgt ctc aag ggg att aag aaa cta 1261Leu Arg Glu Ala Ala Glu Arg Leu Lys Gly Ile Lys Lys Leu

375380385 tagtttgaac aggttgttgg ggg 1284<210>112<211>387<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>112Met Ser Asn Asp Phe Val Val Ser Arg Leu Arg Pro Phe Gly Glu Thr 151015 Ile Phe Ala Thr Met Thr Gln Arg Ala Val Glu Ala Gly Ala Ile Asn

20 25 30Leu Gly Gln Gly Phe Pro Asp Glu Asp Gly Pro Arg Arg Met Leu Glu

35 40 45Ile Ala Ser Glu Gln Ile Leu Gly Gly Asn Asn Gln Tyr Ser Ala Gly

50 55 60Arg Gly Asp Ala Ser Leu Arg Ala Ala Val Ala Arg Asp His Leu Glu 65 70 75 80Arg Phe Asp Leu Glu Tyr Asn Pro Asp Ser Glu Val Leu Ile Thr Val

85 90 95Gly Ala Thr Glu Ala Ile Thr Ala Thr Val Leu Gly Leu Val Glu Pro

100 105 110Gly Asp Glu Val Ile Val Leu Glu Pro Tyr Tyr Asp Ala Tyr Ala Ala

115 120 125Ala Ile Ala Leu Ala Gly Ala Thr Arg Val Ala Val Pro Leu Gln Glu

130 135 140Val Glu Asn Ser Trp Asp Val Asp Val Asp Lys Leu His Ala Ala Val145 150 155 160Thr Lys Lys Thr Arg Met Ile Ile Val Asn Ser Pro His Asn Pro Thr

165 170 175Gly Ser Val Phe Ser Lys Lys Ala Leu Lys Gln Leu Ala Gly Val Ala

180 185 190Arg Ala Tyr Asp Leu Leu Val Leu Ser Asp Glu Val Tyr Glu His Leu

195 200 205Val Phe Asp Asp Gln Lys His Val Ser Val Ala Lys Leu Pro Gly Met

210 215 220Trp Asp Arg Thr Val Thr Val Ser Ser Ala Ala Lys Thr Phe Asn Val225 230 235 240Thr Gly Trp Lys Thr Gly Trp Ala Leu Ala Pro Glu Pro Leu Leu Glu

245 250 255Ala Val Leu Lys Ala Lys Gln Phe Met Ser Tyr Val Gly Ala Thr Pro

260 265 270Phe Gln Pro Ala Val Ala His Ala Ile Glu His Glu Gln Lys Trp Val

275 280 285Ser Lys Met Ser Lys Gly Leu Glu Leu Lys Arg Asp Ile Leu Arg Thr

290 295 300Ala Leu Asp Lys Ala Gly Leu Lys Thr His Asp Ser Met Gly Thr Tyr305 310 315 320Phe Ile Val Ala Asp Ile Gly Asp Arg Asp Gly Ala Glu Phe Cys Phe

325 330 335Glu Leu Ile Glu Lys Val Gly Val Ala Ala Ile Pro Val Gln Ala Phe

340 345 350Val Asp His Pro Lys Lys Trp Ser Ser Lys Val Arg Phe Ala Phe Cys

355 360 365Lys Lys Glu Glu Thr Leu Arg Glu Ala Ala Glu Arg Leu Lys Gly Ile

370375380 Lys Leu385<210>113<211>607<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) · (607)<223>FRXA00116<400>113tttgcgcacc aatcaatggg ggatcaaata tagtagctgc atgagtaatg acttcgtcgt 60ttctaggctt agaccctttg gtgaaacgat ttttgcaacc atg acc cag cga gct 115

Met Thr Gln Arg Ala

1 5gtt gag gcg ggt gca atc aat ctt ggt cag ggc ttt cct gat gag gat 163Val Glu Ala Gly Ala Ile Asn Leu Gly Gln Gly Phe Pro Asp Glu Asp

10 15 20ggt cct cgt cgg atg tta gag atc gcg tcg gag cag att ctc ggg gga 211Gly Pro Arg Arg Met Leu Glu Ile Ala Ser Glu Gln Ile Leu Gly Gly

25 30 35aat aat cag tat tcg gcg ggg cgt ggg gat gct tcg ttg agg gca gct 259Asn Asn Gln Tyr Ser Ala Gly Arg Gly Asp Ala Ser Leu Arg Ala Ala

40 45 50gtg gct cgt gat cat ttg gag agg ttt gat ctg gag tac aac cct gat307Val Ala Arg Asp His Leu Glu Arg Phe Asp Leu Glu Tyr Asn Pro Asp

55 60 65tcg gag gtg ttg atc acg gtg ggg gcc act gag gcg att acg gcg act 355Ser Glu Val Leu Ile Thr Val Gly Ala Thr Glu Ala Ile Thr Ala Thr 70 75 80 85gtg ttg ggt ttg gtg gag cct ggg gat gaa gtg atc gtt ttg gaa ccg 403Val Leu Gly Leu Val Glu Pro Gly Asp Glu Val Ile Val Leu Glu Pro

90 95 100tat tac gat gcg tat gcg gcg gct att gcg ttg gcg ggg gcg acg cgg 451Tyr Tyr Asp Ala Tyr Ala Ala Ala Ile Ala Leu Ala Gly Ala Thr Arg

105 110 115gtg gcg gtt cct ttg cag gag gtg gag aac tcg tgg gat gtg gat gtc 499Val Ala Val Pro Leu Gln Glu Val Glu Asn Ser Trp Asp Val Asp Val

120 125 130gat aag ttg cat gcg gcg gtg act aag aag acg cgg atg att atc gtt 547Asp Lys Leu His Ala Ala Val Thr Lys Lys Thr Arg Met Ile Ile Val

135140145 aat tcg ccg cat aat ccg acg ggt tcg gtg ttt tct aag aag gcg ttg 595Asn Ser Pro His Asn Pro Thr Gly Ser Val Phe Ser Lys Lys Ala Leu 150155160165 aag cag ttg gcg 607Lys Gln Leu Ala<210>114<211>169<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>114Met Thr Gln Arg Ala Val Glu Ala Gly Ala Ile Asn Leu Gly Gln Gly 151015 Phe Pro Asp Glu Asp Gly Pro Arg Arg Met Leu Glu Ile Ala Ser Glu

20 25 30Gln Ile Leu Gly Gly Asn Asn Gln Tyr Ser Ala Gly Arg Gly Asp Ala

35 40 45Ser Leu Arg Ala Ala Val Ala Arg Asp His Leu Glu Arg Phe Asp Leu

50 55 60Glu Tyr Asn ProAsp Ser Glu Val Leu Ile Thr Val Gly Ala Thr Glu 65 70 75 80Ala Ile Thr Ala Thr Val Leu Gly Leu Val Glu Pro Gly Asp Glu Val

85 90 95Ile Val Leu Glu Pro Tyr Tyr Asp Ala Tyr Ala Ala Ala Ile Ala Leu

100 105 110Ala Gly Ala Thr Arg Val Ala Val Pro Leu Gln Glu Val Glu Asn Ser

115 120 125Trp Asp Val Asp Val Asp Lys Leu His Ala Ala Val Thr Lys Lys Thr

130 135 140Arg Met Ile Ile Val Asn Ser Pro His Asn Pro Thr Gly Ser Val Phe145 150 155 160Ser Lys Lys Ala Leu Lys Gln Leu Ala

165<210>115<211>1230<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1207)<223>RXN00618<400>115gctgcattag agggtcgtat ctcgatctaa aagcagtacg cagataggct tgtctcttat 60gaagccaagc actagaagca atgttcagcc gtttcgcgtc atg cag atg ttg gac 115

Met Gln Met Leu Asp

1 5cga gtc cac cgt cgc agg cgc gaa ggc aaa gac acc tta atg ttc tgc 163Arg Val His Arg Arg Arg Arg Glu Gly Lys Asp Thr Leu Met Phe Cys

10 15 20gct ggc cag ccg tca act ggt gcg cca gaa gca gtc atc gaa gaa gca 211Ala Gly Gln Pro Ser Thr Gly Ala Pro Glu Ala Val Ile Glu Glu Ala

25 30 35gag atc gct ctt cgc tcg ggt cct ttg gga tac acc gag gtg att ggt 259Glu Ile Ala Leu Arg Ser Gly Pro Leu Gly Tyr Thr Glu Val Ile Gly

40 45 50gat cgt gag ttc cgt gaa cgc atc gcc gat tgg cac tct gct act tat 307Asp Arg Glu Phe Arg Glu Arg Ile Ala Asp Trp His Ser Ala Thr Tyr

55 60 65gac gta gac acc aac cct gac aat gtt att gtc acc acc ggt tct tca 355Asp Val Asp Thr Asn Pro Asp Asn Val Ile Val Thr Thr Gly Ser Ser 70 75 80 85ggt gga ttc gtg gca tcg ttt atc gcc acc ttg gat cac ggg gat tat 403Gly Gly Phe Val Ala Ser Phe Ile Ala Thr Leu Asp His Gly Asp Tyr

90 95 100gtg gca atg cct acc ccg ggg tac ccg gca tat cgc aat att ctg gaa 451ValAla Met Pro Thr Pro Gly Tyr Pro Ala Tyr Arg Asn Ile Leu Glu

105 110 115tct ttg ggg gcg aag gtt ctg aac ctg cgc tgt act gca gag act cgt 499Ser Leu Gly Ala Lys Val Leu Asn Leu Arg Cys Thr Ala Glu Thr Arg

120 125 130ttc cag cca acc gct caa atg ttg gag gaa ctg cca cac aag ccg aag 547Phe Gln Pro Thr Ala Gln Met Leu Glu Glu Leu Pro His Lys Pro Lys

135 140 145gct gtt att gtc acc agc cca gga aac cca acg ggc acc atc att gat 595Ala Val Ile Val Thr Ser Pro Gly Asn Pro Thr Gly Thr Ile Ile Asp150 155 160 165ccg gaa gag cta gag cgc atc gcc aag tgg tgc gat gac aat gat gct 643Pro Glu Glu Leu Glu Arg Ile Ala Lys Trp Cys Asp Asp Asn Asp Ala

170 175 180gtt ctt atc tct gat gag gac tac cac ggc atg agc ttt ggt cgt ccg 691Val Leu Ile Ser Asp Glu Asp Tyr His Gly Met Ser Phe Gly Arg Pro

185 190 195ctg gca act gcg cat cag ttt tcc aag aac gcc atc gtg gtg ggt acc 739Leu Ala Thr Ala His Gln Phe Ser Lys Asn Ala Ile Val Val Gly Thr

200 205 210ttg tcc aag tac ttc tcc atg acg ggt tgg cgc gtg ggt tgg atc atc 787Leu Ser Lys Tyr Phe Ser Met Thr Gly Trp Arg Val Gly Trp Ile Ile

215 220 225gtt cca gat gag ctg gtc aca ccg att gaa aac ctg cag gct tct ctt 835Val Pro Asp Glu Leu Val Thr Pro Ile Glu Asn Leu Gln Ala Ser Leu230 235 240 245tcc ttg tgt gct cct gcc atc ggg cag gct gcg gga cgc gca gcc ttc 883Ser Leu Cys Ala Pro Ala Ile Gly Gln Ala Ala Gly Arg Ala Ala Phe

250 255 260act ttg gag gct ggg gcc gaa ctt gat gcc cac gtt gaa gcg tat cgc 931Thr Leu Glu Ala Gly Ala Glu Leu Asp Ala His Val Glu Ala Tyr Arg

265 270 275gag gcc cgg gag gtg ttc gtc gat aag ctc cct gaa atc ggg ctt ggc 979Glu Ala Arg Glu Val Phe Val Asp Lys Leu Pro Glu Ile Gly Leu Gly

280 285 290act ttc gcc gac ccg gat ggc ggc ctg tat ttg tgg gtc gat gtt tct 1027Thr Phe Ala Asp Pro Asp Gly Gly Leu Tyr Leu Trp Val Asp Val Ser

295 300 305gca tac acc gat gat tca gag gaa tgg gca ttg cgt ttg ctc gat gaa 1075Ala Tyr Thr Asp Asp Ser Glu Glu Trp Ala Leu Arg Leu Leu Asp Glu310 315 320 325gcg ggc gtg gcc gtc gcg ccg ggt gtt gat ttt gat cct gag gaa ggc 1123Ala Gly Val Ala Val Ala Pro Gly Val Asp Phe Asp Pro Glu Glu Gly

330 335 340cac aag tgg att cgt ttg agc ctg tgc gcg tca aag gaa gac acc att 1171His Lys Trp Ile Arg Leu Ser Leu Cys Ala Ser Lys Glu Asp Thr Ile

345 350 355gaa ggt gtg cgc aaa atc gga gaa ttc atc aaa aaa tagcagcgac 1217Glu Gly Val Arg Lys Ile Gly Glu Phe Ile Lys Lys

360365 taggttagtt tcg 1230<210>116<21l>369<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>116Met Gln Met Leu Asp Arg Val His Arg Arg Arg Arg Glu Gly Lys Asp 151015 Thr Leu Met Phe Cys Ala Gly Gln Pro Ser Thr Gly Ala Pro Glu Ala

20 25 30Val Ile Glu Glu Ala Glu Ile Ala Leu Arg Ser Gly Pro Leu Gly Tyr

35 40 45Thr Glu Val Ile Gly Asp Arg Glu Phe Arg Glu Arg Ile Ala Asp Trp

50 55 60His Ser Ala Thr Tyr Asp Val Asp Thr Asn Pro Asp Asn Val Ile Val 65 70 75 80Thr Thr Gly Ser Ser Gly Gly Phe Val Ala Ser Phe Ile Ala Thr Leu

85 90 95Asp His Gly Asp Tyr Val Ala Met Pro Thr Pro Gly Tyr Pro Ala Tyr

100 105 110Arg Asn Ile Leu Glu Ser Leu Gly Ala Lys Val Leu Asn Leu Arg Cys

115 120 125Thr Ala Glu Thr Arg Phe Gln Pro Thr Ala Gln Met Leu Glu Glu Leu

130 135 140Pro His Lys Pro Lys Ala Val Ile Val Thr Ser Pro Gly Asn Pro Thr145 150 155 160Gly Thr Ile Ile Asp Pro Glu Glu Leu Glu Arg Ile Ala Lys Trp Cys

165 170 175Asp Asp Asn Asp Ala Val Leu Ile Ser Asp Glu Asp Tyr His Gly Met

180 185 190Ser Phe Gly Arg Pro Leu Ala Thr Ala His Gln Phe Ser Lys Asn Ala

195 200 205Ile Val Val Gly Thr Leu Ser Lys Tyr Phe Ser Met Thr Gly Trp Arg

210 215 220Val Gly Trp Ile Ile Val Pro Asp Glu Leu Val Thr Pro Ile Glu Asn225 230 235 240Leu Gln Ala Ser Leu Ser Leu Cys Ala Pro Ala Ile Gly Gln Ala Ala

245 250 255Gly Arg Ala Ala Phe Thr Leu Glu Ala Gly Ala Glu Leu Asp Ala His

260 265 270Val Glu Ala Tyr Arg Glu Ala Arg Glu Val Phe Val Asp Lys Leu Pro

275 280 285Glu Ile Gly Leu Gly Thr Phe Ala Asp Pro Asp Gly Gly Leu Tyr Leu

290 295 300Trp Val Asp Val Ser Ala Tyr Thr Asp Asp Ser Glu Glu Trp Ala Leu305 310 315 320Arg Leu Leu Asp Glu Ala Gly Val Ala Val Ala Pro Gly Val Asp Phe

325 330 335Asp Pro Glu Glu Gly His Lys Trp Ile Arg Leu Ser Leu Cys Ala Ser

340 345 350Lys Glu Asp Thr Ile Glu Gly Val Arg Lys Ile Gly Glu Phe Ile Lys

355360365 Lys<210>117<211>657<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (634)<223>FRXA00618<400>117cccaacgggc accatcattg atccggaaga gctagagcgc atcgccaagt ggtgcgatga 60caatgatgct gttcttatct ctgatgagga ctaccacggc atg agc ttt ggt cgt 115

Met Ser Phe Gly Arg

1 5ccg ctg gca act gcg cat cag ttt tcc aag aac gcc atc gtg gtg ggt 163Pro Leu Ala Thr Ala His Gln Phe Ser Lys Asn Ala Ile Val Val Gly

10 15 20acc ttg tcc aag tac ttc tcc atg acg ggt tgg cgc gtg ggt tgg atc 211Thr Leu Ser Lys Tyr Phe Ser Met Thr Gly Trp Arg Val Gly Trp Ile

25 30 35atc gtt cca gat gag ctg gtc aca ccg att gaa aac ctg cag gct tct 259Ile Val Pro Asp Glu Leu Val Thr Pro Ile Glu Asn Leu Gln Ala Ser

40 45 50ctt tcc ttg tgt gct cct gcc atc ggg cag gct gcg gga cgc gca gcc 307Leu Ser Leu Cys Ala Pro Ala Ile Gly Gln Ala Ala Gly Arg Ala Ala

55 60 65ttc act ttg gag gct ggg gcc gaa ctt gat gcc cac gtt gaa gcg tat 355Phe Thr Leu Glu Ala Gly Ala Glu Leu Asp Ala His Val Glu Ala Tyr 70 75 80 85cgc gag gcc cgg gag gtg ttc gtc gat aag ctc cct gaa atc ggg ctt 403Arg Glu Ala Arg Glu Val Phe Val Asp Lys Leu Pro Glu Ile Gly Leu

90 95 100ggc act ttc gcc gac ccg gat ggc ggc ctg tat ttg tgg gtc gat gtt 451Gly Thr Phe Ala Asp Pro Asp Gly Gly Leu Tyr Leu Trp Val Asp Val

105 110 115tct gca tac acc gat gat tca gag gaa tgg gca ttg cgt ttg ctc gat 499Ser Ala Tyr Thr Asp Asp Ser Glu Glu Trp Ala Leu Arg Leu Leu Asp

120 125 130gaa gcg ggc gtg gcc gtc gcg ccg ggt gtt gat ttt gat cct gag gaa 547Glu Ala Gly Val Ala Val Ala Pro Gly Val Asp Phe Asp Pro Glu Glu

135 140 145ggc cac aag tgg att cgt ttg agc ctgtgc gcg tca aag gaa gac acc 595Gly His Lys Trp Ile Arg Leu Ser Leu Cys Ala Ser Lys Glu Asp Thr150 155 160 165att gaa ggt gtg cgc aaa atc gga gaa ttc atc aaa aaa tagcagcgac 644Ile Glu Gly Val Arg Lys Ile Gly Glu Phe Ile Lys Lys

170175 taggttagtt tcg 657<210>118<211>178<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>118Met Ser Phe Gly Arg Pro Leu Ala Thr Ala His Gln Phe Ser Lys Asn 151015 Ala Ile Val Val Gly Thr Leu Ser Lys Tyr Phe Ser Met Thr Gly Trp

20 25 30Arg Val Gly Trp Ile Ile Val Pro Asp Glu Leu Val Thr Pro Ile Glu

35 40 45Asn Leu Gln Ala Ser Leu Ser Leu Cys Ala Pro Ala Ile Gly Gln Ala

50 55 60Ala Gly Arg Ala Ala Phe Thr Leu Glu Ala Gly Ala Glu Leu Asp Ala 65 70 75 80His Val Glu Ala Tyr Arg Glu Ala Arg Glu Val Phe Val Asp Lys Leu

85 90 95Pro Glu Ile Gly Leu Gly Thr Phe Ala Asp Pro Asp Gly Gly Leu Tyr

100 105 Il0Leu Trp Val Asp Val Ser Ala Tyr Thr Asp Asp Ser Glu Glu Trp Ala

115 120 125Leu Arg Leu Leu Asp Glu Ala Gly Val Ala Val Ala Pro Gly Val Asp

130 135 140Phe Asp Pro Glu Glu Gly His Lys Trp Ile Arg Leu Ser Leu Cys Ala145 150 155 160Ser Lys Glu Asp Thr Ile Glu Gly Val Arg Lys Ile Gly Glu Phe Ile

165170175 Lys Lys<210>119<211>385<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<385><223>FRXA00627<400>119gctgcattag agggtcgtat ctcgatctaa aagcagtacg cagataggct tgtctcttat 60gaagccaagc actagaagca atgttcagcc gtttcgcgtc atg cag atg ttg gac 115

Met Gln Met Leu Asp

1 5cga gtc cac cgt cgc agg cgc gaa ggc aaa gac acc tta atg ttc tgc 163Arg Val His Arg Arg Arg Arg Glu Gly Lys Asp Thr Leu Met Phe Cys

10 15 20gct ggc cag ccg tca act ggt gcg cca gaa gca gtc atc gaa gaa gca 211Ala Gly Gln Pro Ser Thr Gly Ala Pro Glu Ala Val Ile Glu Glu Ala

25 30 35gag atc gct ctt cgc tcg ggt cct ttg gga tac acc gag gtg att ggt 259Glu Ile Ala Leu Arg Ser Gly Pro Leu Gly Tyr Thr Glu Val Ile Gly

40 45 50gat cgt gag ttc cgt gaa cgc atc gcc gat tgg cac tct gct act tat 307Asp Arg Glu Phe Arg Glu Arg Ile Ala Asp Trp His Ser Ala Thr Tyr

55 60 65gac gta gac acc aac cct gac aat gtt att gtc acc acc ggt tct tca 355Asp Val Asp Thr Asn Pro Asp Asn Val Ile Val Thr Thr Gly Ser Ser 70 75 80 85ggt gga ttc gtg gca tcg ttt atc gcc acc 385Gly Gly Phe Val Ala Ser Phe Ile Ala Thr

9095<210>120<211>95<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>120Met Gln Met Leu Asp Arg Val His Arg Arg Arg Arg Glu Gly Lys Asp 15l 015 Thr Leu Met Phe Cys Ala Gly Gln Pro Ser Thr Gly Ala Pro Glu Ala

20 2530Val Ile Glu Glu Ala Glu Ile Ala Leu Arg Ser Gly Pro Leu Gly Tyr

35 40 45Thr Glu Val Ile Gly Asp Arg Glu Phe Arg Glu Arg Ile Ala Asp Trp

50 55 60His Ser Ala Thr Tyr Asp Val Asp Thr Asn Pro Asp Asn Val Ile Val 65 70 75 80Thr Thr Gly Ser Ser Gly Gly Phe Val Ala Ser Phe Ile Ala Thr

859095<210>121<211>1434<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1411)<223>RXA02550<400>121gatcttaggc agccgtggga ttacaccctt ttagagctag aacagtaaaa attcacccaa 60tagctttcaa ctacgcacac aaagtggcaa cattgagcgg gtg act aca gac aag 115

Val Thr Thr Asp Lys

1 5cgc aaa acc tct aag acc acc gac acc gcc aac aag gct gtg ggc gcg 163Arg Lys Thr Ser Lys Thr Thr Asp Thr Ala Asn Lys Ala Val Gly Ala

10 15 20gat cag gca gcg cgt ccc act cgg cga aca act cgc cgc atc ttc gat 211Asp Gln Ala Ala Arg Pro Thr Arg Arg Thr Thr Arg Arg Ile Phe Asp

95 30 35cag tcg gag aag atg aag gac gtg ctg tac gag atc cgt ggc ccg gtg 259Gln Ser Glu Lys Met Lys Asp Val Leu Tyr Glu Ile Arg Gly Pro Val

40 45 50gcc gcg gag gcg gaa cgc atg gag ctt gat ggg cat aac atc tta aag 307Ala Ala Glu Ala Glu Arg Met Glu Leu Asp Gly His Asn Ile Leu Lys

55 60 65ctc aac acg gga aat cca gcc gtg ttc gga ttc gat gcc ccc gac gtg 355Leu Asn Thr Gly Asn Pro Ala Val Phe Gly Phe Asp Ala Pro Asp Val 70 75 80 85att atg cgt gac atg atc gcc aac ctt cca act tcc caa ggg tat tcc 403Ile Met Arg Asp Met Ile Ala Asn Leu Pro Thr Ser Gln Gly Tyr Ser

90 95 100acc tcc aaa ggc att att ccg gcc cgg cga gca gtg gtc acc cgc tac 451Thr Ser Lys Gly Ile Ile Pro Ala Arg Arg Ala Val Val Thr Arg Tyr

105 110 115gaa gtt gtg ccc gga ttc ccc cac ttc gat gtt gat gat gtg ttc tta 499Glu Val Val Pro Gly Phe Pro His Phe Asp Val Asp Asp Val Phe Leu

120 125 130ggc aac ggt gtc tca gaa cta atc acc atg acc acc caa gca ctc ctc 547Gly Asn Gly Val Ser Glu Leu Ile Thr Met Thr Thr Gln Ala Leu Leu

135 140 145aac gac ggc gat gaa gtt ctt atc ccc gca ccg gac tac cca ctg tgg 595Asn Asp Gly Asp Glu Val Leu Ile Pro Ala Pro Asp Tyr Pro Leu Trp150 155 160 165act gcc gca acc tcc ctg gct ggt ggt aag cct gtg cac tac ctc tgt 643Thr Ala Ala Thr Ser Leu Ala Gly Gly Lys Pro Val His Tyr Leu Cys

170 175 180gat gag gaa gat gac tgg aac cca tcc atc gaa gac atc aag tcc aaa 691Asp Glu Glu Asp Asp Trp Asn Pro Ser Ile Glu Asp Ile Lys Ser Lys

185 190 195atc tca gag aaa acc aaa gct att gtg gtg atc aac ccc aac aac ccc 739Ile Ser Glu Lys Thr Lys Ala Ile Val Val Ile Asn Pro Asn Asn Pro

200 205 210acg gga gct gtc tac ccg cgc cgg gtg ttg gaa caa atc gtc gag att 787Thr Gly Ala Val Tyr Pro Arg Arg Val Leu Glu Gln Ile Val Glu Ile

215 220225gca cgc gag cat gac ctg ctg att ttg gcc gat gaa atc tac gac cgc 835Ala Arg Glu His Asp Leu Leu Ile Leu Ala Asp Glu Ile Tyr Asp Arg230 235 240 245att ctc tac gat gat gcc gag cac atc agc ctg gca acc ctt gca cca 883Ile Leu Tyr Asp Asp Ala Glu His Ile Ser Leu Ala Thr Leu Ala Pro

250 255 260gat ctc ctt tgc atc aca tac aac ggt cta tcc aag gca tac cgc gtc 931Asp Leu Leu Cys Ile Thr Tyr Asn Gly Leu Ser Lys Ala Tyr Arg Val

265 270 275gca gga tac cga gct ggc tgg atg gta ttg act gga cca aag caa tac 979Ala Gly Tyr Arg Ala Gly Trp Met Val Leu Thr Gly Pro Lys Gln Tyr

280 285 290gca cgt gga ttt att gag ggc ctc gaa ctc ctc gca ggc act cga ctc 1027Ala Arg Gly Phe Ile Glu Gly Leu Glu Leu Leu Ala Gly Thr Arg Leu

295 300 305tgc cca aat gtc cca gct cag cac gct att cag gta gct ctg ggt gga 1075Cys Pro Asn Val Pro Ala Gln His Ala Ile Gln Val Ala Leu Gly Gly310 315 320 325cgc cag tcc atc tac gac ctc act ggc gaa cac ggc cga ctc ctg gaa 1123Arg Gln Ser Ile Tyr Asp Leu Thr Gly Glu His Gly Arg Leu Leu Glu

330 335 340cag cgc aac atg gca tgg acg aaa ctc aac gaa atc cca ggt gtc agc 1171Gln Arg Asn Met Ala Trp Thr Lys Leu Asn Glu Ile Pro Gly Val Ser

345 350 355tgt gtg aaa cca atg gga gct cta tac gcg ttc ccc aag ctc gac ccc 1219Cys Val Lys Pro Met Gly Ala Leu Tyr Ala Phe Pro Lys Leu Asp Pro

360 365 370aac gtg tac gaa atc cac gac gac acc caa ctc atg ctg gat ctt ctc 1267Asn Val Tyr Glu Ile His Asp Asp Thr Gln Leu Met Leu Asp Leu Leu

375 380 385cgt gcc gag aaa atc ctc atg gtt cag ggc act ggc ttc aac tgg cca 1315Arg Ala Glu Lys Ile Leu Met Val Gln Gly Thr Gly Phe Asn Trp Pro390 395 400 405cat cac gat cac ttc cga gtg gtc acc ctg cca tgg gca tcc cag ttg 1363His His Asp His Phe Arg Val Val Thr Leu Pro Trp Ala Ser Gln Leu

410 415 420gaa aac gca att gag cgc ctg ggt aac ttc ctg tcc act tac aag cag 1411Glu Asn Ala Ile Glu Arg Leu Gly Asn Phe Leu Ser Thr Tyr Lys Gln

425430435 tagtagttgt taggattcac cac 1434<210>122<211>437<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>122Val Thr Thr Asp Lys Arg Lys Thr Ser Lys Thr Thr Asp Thr Ala Asn 151015 Lys Ala Val Gly Ala Asp Gln Ala Ala Arg Pro Thr Arg Arg Thr Thr

20 25 30Arg Arg Ile Phe Asp Gln Ser Glu Lys Met Lys Asp Val Leu Tyr Glu

35 40 45Ile Arg Gly Pro Val Ala Ala Glu Ala Glu Arg Met Glu Leu Asp Gly

50 55 60His Asn Ile Leu Lys Leu Asn Thr Gly Asn Pro Ala Val Phe Gly Phe 65 70 75 80Asp Ala Pro Asp Val Ile Met Arg Asp Met Ile Ala Asn Leu Pro Thr

85 90 95Ser Gln Gly Tyr Ser Thr Ser Lys Gly Ile Ile Pro Ala Arg Arg Ala

100 105 110Val Val Thr Arg Tyr Glu Val Val Pro Gly Phe Pro His Phe Asp Val

115 120 125Asp Asp Val Phe Leu Gly Asn Gly Val Ser Glu Leu Ile Thr Met Thr

130 135 140Thr Gln Ala Leu Leu Asn Asp Gly Asp Glu Val Leu Ile Pro Ala Pro145 150 155 160Asp Tyr Pro Leu Trp Thr Ala Ala Thr Ser Leu Ala Gly Gly Lys Pro

165 170 175Val His Tyr Leu Cys Asp Glu Glu Asp Asp Trp Asn Pro Ser Ile Glu

180 185 190Asp Ile Lys Ser Lys Ile Ser Glu Lys Thr Lys Ala Ile Val Val Ile

195 200 205Asn Pro Asn Asn Pro Thr Gly Ala Val Tyr Pro Arg Arg Val Leu Glu

210 215 220Gln Ile Val Glu Ile Ala Arg Glu His Asp Leu Leu Ile Leu Ala Asp225 230 235 240Glu Ile Tyr Asp Arg Ile Leu Tyr Asp Asp Ala Glu His Ile Ser Leu

245 250 255Ala Thr Leu Ala Pro Asp Leu Leu Cys Ile Thr Tyr Asn Gly Leu Ser

260 265 270Lys Ala Tyr Arg Val Ala Gly Tyr Arg Ala Gly Trp Met Val Leu Thr

275 280 285Gly Pro Lys Gln Tyr Ala Arg Gly Phe Ile Glu Gly Leu Glu Leu Leu

290 295 300Ala Gly Thr Arg Leu Cys Pro Asn Val Pro Ala Gln His Ala Ile Gln305 310 315 320Val Ala Leu Gly Gly Arg Gln Ser Ile Tyr Asp Leu Thr Gly Glu His

325 330 335Gly Arg Leu Leu Glu Gln Arg Asn Met Ala Trp Thr Lys Leu Asn Glu

340 345 350Ile Pro Gly Val Ser Cys Val Lys Pro Met Gly Ala Leu Tyr Ala Phe

355 360 365Pro Lys Leu Asp Pro Asn Val Tyr Glu Ile His Asp Asp Thr Gln Leu

370 375 380Met Leu Asp Leu Leu Arg Ala Glu Lys Ile Leu Met Val Gln Gly Thr385 390 395 400Gly Phe Asn Trp Pro His His Asp His Phe Arg Val Val Thr Leu Pro

405 410 415Trp Ala Ser Gln Leu Glu Asn Ala Ile Glu Arg Leu Gly Asn Phe Leu

420 425 430Ser Thr Tyr Lys Gln

435<210>123<211>1701<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1678)<223>RXA02193<400>123cccccgaaaa tgtagtgggt agttccacac tgcctcttac aagtacgtag gataatccac 60agcaccattg tgatttcctt caacttgtga gaggcagtac atg tct aag acg agc 115

Met Ser Lys Thr Ser

1 5aac aag tct tca gca gac tca aag aat gac gca aaa gcc gaa gac att 163Asn Lys Ser Ser Ala Asp Ser Lys Asn Asp Ala Lys Ala Glu Asp Ile

10 15 20gtg aac ggc gag aac caa atc gcc acg aat gag tcg cag tct tca gac 211Val Asn Gly Glu Asn Gln Ile Ala Thr Asn Glu Ser Gln Ser Ser Asp

25 30 35agc gct gca gtt tcg gaa cgt gtc gtc gaa cca aaa acc acg gtt cag 259Ser Ala Ala Val Ser Glu Arg Val Val Glu Pro Lys Thr Thr Val Gln

40 45 50aaa aag ttc cga atc gaa tcg gat ctg ctt ggt gaa ctt cag atc cca 307Lys Lys Phe Arg Ile Glu Ser Asp Leu Leu Gly Glu Leu Gln IlePro

55 60 65tcc cac gca tat tac ggg gtg cac acc ctt cgt gcg gtg gac aac ttc 355Ser His Ala Tyr Tyr Gly Val His Thr Leu Arg Ala Val Asp Asn Phe 70 75 80 85caa atc tca cga acc acc atc aac cac gtc cca gat ttc att cgc ggc 403Gln Ile Ser Arg Thr Thr Ile Asn His Val Pro Asp Phe Ile Arg Gly

90 95 100atg gtc cag gtg aaa aag gcc gca gct tta gca aac cgc cga ctg cac 451Met Val Gln Val Lys Lys Ala Ala Ala Leu Ala Asn Arg Arg Leu His

105 110 115aca ctt cca gca caa aaa gca gaa gca att gtc tgg gct tgt gat cag 499Thr Leu Pro Ala Gln Lys Ala Glu Ala Ile Val Trp Ala Cys Asp Gln

120 125 130atc ctc att gag gaa cgc tgt atg gat cag ttc ccc atc gat gtg ttc 547Ile Leu Ile Glu Glu Arg Cys Met Asp Gln Phe Pro Ile Asp Val Phe

135 140 145cag ggt ggc gca ggt acc tca ctg aac atg aac acc aac gag gtt gtt 595Gln Gly Gly Ala Gly Thr Ser Leu Asn Met Asn Thr Asn Glu Val Val150 155 160 165gcc aac ctt gca ctt gag ttc tta ggc cat gaa aag ggc gag tac cac 643Ala Asn Leu Ala Leu Glu Phe Leu Gly His Glu Lys Gly Glu Tyr His

170 175 180atc ctg cac ccc atg gat gat gtg aac atg tcc cag tcc acc aac gat 691Ile Leu His Pro Met Asp Asp Val Asn Met Ser Gln Ser Thr Asn Asp

185 190 195tcc tac cca act ggt ttc cgc ctg ggc att tac gct gga ctg cag acc 739Ser Tyr Pro Thr Gly Phe Arg Leu Gly Ile Tyr Ala Gly Leu Gln Thr

200 205 210ctc atc gct gaa att gat gag ctt cag gtt gcg ttc cgc cac aag ggc 787Leu Ile Ala Glu Ile Asp Glu Leu Gln Val Ala Phe Arg His Lys Gly

215 220 225aat gag ttt gtc gac atc atc aag atg ggc cgc acc cag ttg cag gat 835Asn Glu Phe Val Asp Ile Ile Lys Met Gly Arg Thr Gln Leu Gln Asp230 235 240 245gct gtt ccc atg agc ttg ggc gaa gag ttc cga gca ttc gcg cac aac 883Ala Val Pro Met Ser Leu Gly Glu Glu Phe Arg Ala Phe Ala His Asn

250 255 260ctc gca gaa gag cag acc gtg ctg cgt gaa gct gcc aac cgt ctc ctc 931Leu Ala Glu Glu Gln Thr Val Leu Arg Glu Ala Ala Asn Arg Leu Leu

265 270 275gag gtc aat ctt ggt gca acc gca atc ggt act ggt gtg aac act cca 979Glu Val Asn Leu Gly Ala Thr Ala Ile Gly Thr Gly Val Asn Thr Pro

280 285 290gca ggc tac cgc cac cag gtt gtc gct gct ctg tct gag gtc acc gga 1027Ala Gly Tyr Arg His Gln Val Val Ala Ala Leu Ser Glu Val Thr Gly

295 300 305ctg gaa cta aag tcc gca cgt gat ctc atc gag gct acc tct gac acc 1075Leu Glu Leu Lys Ser Ala Arg Asp Leu Ile Glu Ala Thr Ser Asp Thr310 315 320 325ggt gca tat gtt cat gcg cac tcc gca atc aag cgt gca gcc atg aaa 1123Gly Ala Tyr Val His Ala His Ser Ala Ile Lys Arg Ala Ala Met Lys

330 335 340ctg tcc aag atc tgt aac gat cta cgt ctg ctg tct tct ggt cct cgt 1171Leu Ser Lys Ile Cys Asn Asp Leu Arg Leu Leu Ser Ser Gly Pro Arg

345 350 355gct ggc ttg aac gaa atc aac ctg cca cca cgc cag gct ggt tcc tcc 1219Ala Gly Leu Asn Glu Ile Asn Leu Pro Pro Arg Gln Ala Gly Ser Ser

360 365 370atc atg cca gcc aag gtc aac cca gtg atc cca gaa gtg gtc aac cag 1267Ile Met Pro Ala Lys Val Asn Pro Val Ile Pro Glu Val Val Asn Gln

375 380 385gtc tgc ttc aag gtc ttc ggt aac gat ctc acc gtc acc atg gct gcg 1315Val Cys Phe Lys Val Phe Gly Asn Asp Leu Thr Val Thr Met Ala Ala390 395 400 405gaa gct ggc cag ttg cag ctc aac gtc atg gag cca gtc att ggc gaa 1363Glu Ala Gly Gln Leu Gln Leu Asn Val Met Glu Pro Val Ile Gly Glu

410 415 420tcc ctc ttc cag tca ctg cgc atc ctg ggc aat gca gcc aag act ttg 1411Ser Leu Phe Gln Ser Leu Arg Ile Leu Gly Asn Ala Ala Lys Thr Leu

425 430 435cgt gag aag tgc gtc gta gga atc acc gcc aac gct gat gtt tgc cgt 1459Arg Glu Lys Cys Val Val Gly Ile Thr Ala Asn Ala Asp Val Cys Arg

440 445 450gct tac gtt gat aac tcc atc ggg att atc act tac ctg aac cca ttc 1507Ala Tyr Val Asp Asn Ser Ile Gly Ile Ile Thr Tyr Leu Asn Pro Phe

455 460 465ctg ggc cac gac att gga gat cag atc ggt aag gaa gca gcc gaa act 1555Leu Gly His Asp Ile Gly Asp Gln Ile Gly Lys Glu Ala Ala Glu Thr470 475 480 485ggt cga cca gtg cgt gaa ctc atc ctg gaa aag aag ctc atg gat gaa 1603Gly Arg Pro Val Arg Glu Leu Ile Leu Glu Lys Lys Leu Met Asp Glu

490 495 500aag acg ctc gag gca gtc ctg tcc aag gag aac ctc atg cac cca atg 1651Lys Thr Leu Glu Ala Val Leu Ser Lys Glu Asn Leu Met His Pro Met

505 510 515ttc cgc gga agg ctc tac ttg gag aac taatccaaga tctcgtctga 1698Phe Arg Gly Arg Leu Tyr Leu Glu Asn

520525 tac 1701<210>124<211>526<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>124Met Ser Lys Thr Ser Asn Lys Ser Ser Ala Asp Ser Lys Asn Asp Ala 151015 Lys Ala Glu Asp Ile Val Asn Gly Glu Asn Gln Ile Ala Thr Asn Glu

20 25 30Ser Gln Ser Ser Asp Ser Ala Ala Val Ser Glu Arg Val Val Glu Pro

35 40 45Lys Thr Thr Val Gln Lys Lys Phe Arg Ile Glu Ser Asp Leu Leu Gly

50 55 60Glu Leu Gln Ile Pro Ser His Ala Tyr Tyr Gly Val His Thr Leu Arg 65 70 75 80Ala Val Asp Asn Phe Gln Ile Ser Arg Thr Thr Ile Asn His Val Pro

85 90 95Asp Phe Ile Arg Gly Met Val Gln Val Lys Lys Ala Ala Ala Leu Ala

100 105 110Asn Arg Arg Leu His Thr Leu Pro Ala Gln Lys Ala Glu Ala Ile Val

115 120 125Trp Ala Cys Asp Gln Ile Leu Ile Glu Glu Arg Cys Met Asp Gln Phe

130 135 140Pro Ile Asp Val Phe Gln Gly Gly Ala Gly Thr Ser Leu Asn Met Asn145 150 155 160Thr Asn Glu Val Val Ala Asn Leu Ala Leu Glu Phe Leu Gly His Glu

165 170 175Lys Gly Glu Tyr His Ile Leu His Pro Met Asp Asp Val Asn Met Ser

180 185 190Gln Ser Thr Asn Asp Ser Tyr Pro Thr Gly Phe Arg Leu Gly Ile Tyr

195 200205Ala Gly Leu Gln Thr Leu Ile Ala Glu Ile Asp Glu Leu Gln Val Ala

210 215 220Phe Arg His Lys Gly Asn Glu Phe Val Asp Ile Ile Lys Met Gly Arg225 230 235 240Thr Gln Leu Gln Asp Ala Val Pro Met Ser Leu Gly Glu Glu Phe Arg

245 250 255Ala Phe Ala His Asn Leu Ala Glu Glu Gln Thr Val Leu Arg Glu Ala

260 265 270Ala Asn Arg Leu Leu Glu Val Asn Leu Gly Ala Thr Ala Ile Gly Thr

275 280 285Gly Val Asn Thr Pro Ala Gly Tyr Arg His Gln Val Val Ala Ala Leu

290 295 300Ser Glu Val Thr Gly Leu Glu Leu Lys Ser Ala Arg Asp Leu Ile Glu305 310 315 320Ala Thr Ser Asp Thr Gly Ala Tyr Val His Ala His Ser Ala Ile Lys

325 330 335Arg Ala Ala Met Lys Leu Ser Lys Ile Cys Asn Asp Leu Arg Leu Leu

340 345 350Ser Ser Gly Pro Arg Ala Gly Leu Asn Glu Ile Asn Leu Pro Pro Arg

355 360 365Gln Ala Gly Ser Ser Ile Met Pro Ala Lys Val Asn Pro Val Ile Pro

370 375 380Glu Val Val Asn Gln Val Cys Phe Lys Val Phe Gly Asn Asp Leu Thr385 390 395 400Val Thr Met Ala Ala Glu Ala Gly Gln Leu Gln Leu Asn Val Met Glu

405 410 415Pro Val Ile Gly Glu Ser Leu Phe Gln Ser Leu Arg Ile Leu Gly Asn

420 425430Ala Ala Lys Thr Leu Arg Glu Lys Cys Val Val Gly Ile Thr Ala Asn

435 440 445Ala Asp Val Cys Arg Ala Tyr Val Asp Asn Ser Ile Gly Ile Ile Thr

450 455 460Tyr Leu Asn Pro Phe Leu Gly His Asp Ile Gly Asp Gln Ile Gly Lys465 470 475 480Glu Ala Ala Glu Thr Gly Arg Pro Val Arg Glu Leu Ile Leu Glu Lys

485 490 495Lys Leu Met Asp Glu Lys Thr Leu Glu Ala Val Leu Ser Lys Glu Asn

500 505 510Leu Met His Pro Met Phe Arg Gly Arg Leu Tyr Leu Glu Asn

515520525<210>125<211>1098<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1075)<223>RXA02432<400>125cacgtgattc atttgtgacc aacaaccgaa actgagccag aagactgtca atcccctgct 60gtgcacataa caactgcagc tagttgatac gctagagcgc atg tcg aag cag cac 115

Met Ser Lys Gln His

1 5tcc aca cca tta aac aat gat gaa gaa cac act tcc gct cct caa aag 163Ser Thr Pro Leu Asn Asn Asp Glu Glu His Thr Ser Ala Pro Gln Lys

10 15 20gtt gcg gta atc acc acg ggc gga acc atc gcc tgt act tcc gac gca 211Val Ala Val Ile Thr Thr Gly Gly Thr Ile Ala Cys Thr Ser Asp Ala

25 30 35aat ggg cat ctg ctt ccc acc gtc agc ggt gca gac ctg ctt gcg cca 259Asn Gly His Leu Leu Pro Thr Val Ser Gly Ala Asp Leu Leu Ala Pro

40 45 50atc gca cca cgg ttc aat gga gcg cag atc gct ttc gaa atc cac gaa 307Ile Ala Pro Arg Phe Asn Gly Ala Gln Ile Ala Phe Glu Ile His Glu

55 60 65atc aac cgc ctt gat tcc tcc tcc atg acg ttt gag gat ctc gat tcc 355Ile Asn Arg Leu Asp Ser Ser Ser Met Thr Phe Glu Asp Leu Asp Ser 70 75 80 85atc atc gcc acg gtt cat aag gtg ttg gag gat ccg gat gtt gtt ggc 403Ile Ile Ala Thr Val His Lys Val Leu Glu Asp Pro Asp Val Val Gly

90 95 100gta gta gtt acc cac ggc acc gat tcc atg gaa gag tcc gcc atc gcc 451Val Val Val Thr His Gly Thr Asp Ser Met Glu Glu Ser Ala Ile Ala

105 110 115gta gac acc ttc ctt gat gat ccc cgc cca gtc att ttc acc ggc gcc 499Val Asp Thr Phe Leu Asp Asp Pro Arg Pro Val Ile Phe Thr Gly Ala

120 125 130caa aaa ccc ttc gat cat ccc gaa gcc gac ggc cca aac aac ctt ttc 547Gln Lys Pro Phe Asp His Pro Glu Ala Asp Gly Pro Asn Asn Leu Phe

135 140 145gaa gcc tgc ctc atc gca tcc gac ccc tcc gct cgc gga att ggt gca 595Glu Ala Cys Leu Ile Ala Ser Asp Pro Ser Ala Arg Gly Ile Gly Ala150 155 160 165ctc att gtc ttc ggt cac gcc gtc atc cct gct cgc ggc tgc gtt aaa 643Leu Ile Val Phe Gly His Ala Val Ile Pro Ala Arg Gly Cys Val Lys

170 175 180tgg cac acc tct gat gag ctg gcg ttt gca acc aac ggc cct gaa gaa 691Trp His Thr Ser Asp Glu Leu Ala Phe Ala Thr Asn Gly Pro Glu Glu

185 190 195cca gag cgc ccc gat gcg ctg ccc gta gct aaa ttg gcg gat gtc tct 739Pro Glu Arg Pro Asp Ala Leu Pro Val Ala Lys LeuAla Asp Val Ser

200 205 210gtc gaa atc atc ccc gca tac cct ggt gcc acc ggc gca atg gtg gaa 787Val Glu Ile Ile Pro Ala Tyr Pro Gly Ala Thr Gly Ala Met Val Glu

215 220 225gct gcc atc gct gcc ggt gct caa gga ctt gta gtg gaa gca atg gga 835Ala Ala Ile Ala Ala Gly Ala Gln Gly Leu Val Val Glu Ala Met Gly230 235 240 245tca ggc aat gtt ggt tcc cgc atg ggt gat gcc cta ggt aaa gca ctt 883Ser Gly Asn Val Gly Ser Arg Met Gly Asp Ala Leu Gly Lys Ala Leu

250 255 260gac gct gga att ccc gtg gtg atg agc act agg gtt cct cgt ggt gaa 931Asp Ala Gly Ile Pro Val Val Met Ser Thr Arg Val Pro Arg Gly Glu

265 270 275gta tcc gga gtg tat ggc ggt gca ggt gga ggt gcg act ttg gct gcg 979Val Ser Gly Val Tyr Gly Gly Ala Gly Gly Gly Ala Thr Leu Ala Ala

280 285 290aag ggc gct gtg gga tct cgc tac ttc aga gct ggt cag gca cgt att 1027Lys Gly Ala Val Gly Ser Arg Tyr Phe Arg Ala Gly Gln Ala Arg Ile

295300305 ttg ctc gcg att gcc att gcg acg ggc gca cat ccg gtg acg ctt tac 1075Leu Leu Ala Ile Ala Ile Ala Thr Gly Ala His Pro Val Thr Leu Tyr 310315320325 taatttcgcc cttggtcttg cat 1098<210>126<211>325<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>126Met Ser Lys Gln His Ser Thr Pro Leu Asn Asn Asp Glu Glu His Thr 15l 015 Ser Ala Pro Gln Lys Val Ala Val Ile Thr Thr Gly Gly Thr Ile Ala

20 25 30Cys Thr Ser Asp Ala Asn Gly His Leu Leu Pro Thr Val Ser Gly Ala

35 40 45Asp Leu Leu Ala Pro Ile Ala Pro Arg Phe Asn Gly Ala Gln Ile Ala

50 55 60Phe Glu Ile His Glu Ile Asn Arg Leu Asp Ser Ser Ser Met Thr Phe65 70 75 80Glu Asp Leu Asp Ser Ile Ile Ala Thr Val His Lys Val Leu Glu Asp

85 90 95Pro Asp Val Val Gly Val Val Val Thr His Gly Thr Asp Ser Met Glu

100 105 110Glu Ser Ala Ile Ala Val Asp Thr Phe Leu Asp Asp Pro Arg Pro Val

115 120 125Ile Phe Thr Gly Ala Gln Lys Pro Phe Asp His Pro Glu Ala Asp Gly

130 135 140Pro Asn Asn Leu Phe Glu Ala Cys Leu Ile Ala Ser Asp Pro Ser Ala145 150 155 160Arg Gly Ile Gly Ala Leu Ile Val Phe Gly His Ala Val Ile Pro Ala

165 170 175Arg Gly Cys Val Lys Trp His Thr Ser Asp Glu Leu Ala Phe Ala Thr

180 185 190Asn Gly Pro Glu Glu Pro Glu Arg Pro Asp Ala Leu Pro Val Ala Lys

195 200 205Leu Ala Asp Val Ser Val Glu Ile Ile Pro Ala Tyr Pro Gly Ala Thr

210 215 220Gly Ala Met Val Glu Ala Ala Ile Ala Ala Gly Ala Gln Gly Leu Val225 230 235 240Val Glu Ala Met Gly Ser Gly Asn Val Gly Ser Arg Met Gly Asp Ala

245 250 255Leu Gly Lys Ala Leu Asp Ala Gly Ile Pro Val Val Met Ser Thr Arg

260 265 270Val Pro Arg Gly Glu Val Ser Gly Val Tyr Gly Gly Ala Gly Gly Gly

275 280 285Ala Thr Leu Ala Ala Lys Gly Ala Val Gly Ser Arg Tyr Phe Arg Ala

290 295 300

Gly Gln Ala Arg Ile Leu Leu Ala Ile Ala Ile Ala Thr Gly Ala His305 310 315 320Pro Val Thr Leu Tyr

325<210>127<211>775<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (775)<223>RXN03003<400>127tcgatgatct gggctcccca ggtggtgcgg ctaagcttgg accacaagat tttgatcacc 60caatgatcgc tgcgctgccg cctcaggcat aatctaacgc atg acc tct cgc acc 115

Met Thr Ser Arg Thr

1 5ccg ctt gtt tct gtt ctt cct gat ttt ccg tgg gat tcg ctc gct tcc 163Pro Leu Val Ser Val Leu Pro Asp Phe Pro Trp Asp Ser Leu Ala Ser

10 15 20gca aaa gcc aaa gct gcg tct cac ccg gat ggg atc gtg aat ctt tct 211Ala Lys Ala Lys Ala Ala Ser His Pro Asp Gly Ile Val Asn Leu Ser

25 30 35gtt ggc act ccg gtt gat ccg gtc gcg ccc agc att cag atc gcg ttg 259Val Gly Thr Pro Val Asp Pro Val Ala Pro Ser Ile Gln Ile Ala Leu

40 45 50gca gaa gca gcg ggg ttt tcg ggt tac cct caa acc atc ggc acc ccg 307Ala Glu Ala Ala Gly Phe Ser Gly Tyr Pro Gln Thr Ile Gly Thr Pro

55 60 65gaa ctc cgc gca gcc atc agg ggc gcg ctt gag cgg cgc tac aac atg 355Glu Leu Arg Ala Ala Ile Arg Gly Ala Leu Glu Arg Arg Tyr Asn Met 7075 80 85aca aag ctt gtc gac gcc tcc ctc ctc ccc gtc gtg ggt acc aag gag 403Thr Lys Leu Val Asp Ala Ser Leu Leu Pro Val Val Gly Thr Lys Glu

90 95 100gca att gcc ctt ctt cca ttc gcg ttg ggt att tcc ggc acc gtt gtc 451Ala Ile Ala Leu Leu Pro Phe Ala Leu Gly Ile Ser Gly Thr Val Val

105 110 115atc cca gag att gcg tac cca acc tac gaa gtc gct gtc gtg gcc gca 499Ile Pro Glu Ile Ala Tyr Pro Thr Tyr Glu Val Ala Val Val Ala Ala

120 125 130gga tgc acc gtg ttg cgt tct gat tcg ctg ttt aag ctc ggc ccg cag 547Gly Cys Thr Val Leu Arg Ser Asp Ser Leu Phe Lys Leu Gly Pro Gln

135 140 145atc ccg tcg atg atg ttt atc aac tca cca tcc aac ccc aca ggc aag 595Ile Pro Ser Met Met Phe Ile Asn Ser Pro Ser Asn Pro Thr Gly Lys150 155 160 165gtt ctg ggc atc cca cac ttg cgc aag gtt gtg aag tgg gcg cag gaa 643Val Leu Gly Ile Pro His Leu Arg Lys Val Val Lys Trp Ala Gln Glu

170 175 180aac aac gtg atc ctc gca gct gat gaa tgc tac ttg ggt ctt ggc tgg 691Asn Asn Val Ile Leu Ala Ala Asp Glu Cys Tyr Leu Gly Leu Gly Trp

185 190 195gac gat gaa aac cca ccg atc tca att ttg gat cca cgt gtc tgc gat 739Asp Asp Glu Asn Pro Pro Ile Ser Ile Leu Asp Pro Arg Val Cys Asp

200 205 210ggc gac cac acc aac ttg atc gcc att cac tcg ctg 775Gly Asp His Thr Asn Leu Ile Ala Ile His Ser Leu

215220225<210>128<211>225<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>128Met Thr Ser Arg Thr Pro Leu Val Ser Val Leu Pro Asp Phe Pro Trp 151015 Asp Ser Leu Ala Ser Ala Lys Ala Lys Ala Ala Ser His Pro Asp Gly

20 25 30Ile Val Asn Leu Ser Val Gly Thr Pro Val Asp Pro Val Ala Pro Ser

35 40 45Ile Gln Ile Ala Leu Ala Glu Ala Ala Gly Phe Ser Gly Tyr Pro Gln

50 55 60Thr Ile Gly Thr Pro Glu Leu Arg Ala Ala Ile Arg Gly Ala Leu Glu 65 70 75 80Arg Arg Tyr Asn Met Thr Lys Leu Val Asp Ala Ser Leu Leu Pro Val

85 90 95Val Gly Thr Lys Glu Ala Ile Ala Leu Leu Pro Phe Ala Leu Gly Ile

100 105 110Ser Gly Thr Val Val Ile Pro Glu Ile Ala Tyr Pro Thr Tyr Glu Val

115 120 125Ala Val Val Ala Ala Gly Cys Thr Val Leu Arg Ser Asp Ser Leu Phe

130 135 140Lys Leu Gly Pro Gln Ile Pro Ser Met Met Phe Ile Asn Ser Pro Ser145 150 155 160Asn Pro Thr Gly Lys Val Leu Gly Ile Pro His Leu Arg Lys Val Val

165 170 175Lys Trp Ala Gln Glu Asn Asn Val Ile Leu Ala Ala Asp Glu Cys Tyr

180 185 190Leu Gly Leu Gly Trp Asp Asp Glu Asn Pro Pro Ile Ser Ile Leu Asp

195 200 205Pro Arg Val Cys Asp Gly Asp His Thr Asn Leu Ile Ala Ile His Ser

210215220 Leu225<210>129<211>1206<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1183)<223>RXN00508<400>129agccacgtgt ttaaggatag ttgaaagcgt ggggcaatac tggcactaac cccggcacca 60atcgtatttc tgtccgcggt tggtggcaca atagttcaac atg aac ttg ctg acc 115

Met Asn Leu Leu Thr

1 5acc aaa att gac ctg gat gcc atc gcc cat aac acg agg gtg ctt aaa 163Thr Lys Ile Asp Leu Asp Ala Ile Ala His Asn Thr Arg Val Leu Lys

10 15 20caa atg gcg ggt ccg gcg aag ctg atg gcg gtg gtg aag gcg aat gca 211Gln Met Ala Gly Pro Ala Lys Leu Met Ala Val Val Lys Ala Asn Ala

25 30 35tat aac cat ggc gta gag aag gtc gct ccg gtt att gct gct cat ggt 259Tyr Asn His Gly Val Glu Lys Val Ala Pro Val Ile Ala Ala His Gly

40 45 50gcg gat gcg ttt ggt gtg gca act ctt gcg gag gct atg cag ttg cgt 307Ala Asp Ala Phe Gly Val Ala Thr Leu Ala Glu Ala Met Gln Leu Arg

55 60 65gat atc ggc atc agc caa gag gtt ttg tgt tgg att tgg aca ccg gag 355Asp Ile Gly Ile Ser Gln Glu Val Leu Cys Trp Ile Trp Thr Pro Glu 70 75 80 85cag gat ttc cgc gcc gcc att gat cgc aat att gat ttg gct gtt att 403Gln Asp Phe Arg Ala Ala Ile Asp Arg Asn Ile Asp Leu Ala Val Ile

90 95 100tct ccc gcg cat gcc aaa gcc ttg atc gaa act gat gcg gag cat att 451Ser Pro Ala His Ala Lys Ala Leu Ile Glu Thr Asp Ala Glu His Ile

105 110 115cgg gtg tcc atc aag att gattct ggg ttg cat cgt tcg ggt gtg gat 499Arg Val Ser Ile Lys Ile Asp Ser Gly Leu His Arg Ser Gly Val Asp

120 125 130gag cag gag tgg gag ggc gtg ttc agc gcg ttg gct gct gcc ccg cac 547Glu Gln Glu Trp Glu Gly Val Phe Ser Ala Leu Ala Ala Ala Pro His

135 140 145att gag gtc acg ggc atg ttc acg cac ttg gcg tgc gcg gat gag cca 595Ile Glu Val Thr Gly Met Phe Thr His Leu Ala Cys Ala Asp Glu Pro150 155 160 165gag aat ccg gaa act gat cgc caa att att gct ttt cga cgc gcc ctt 643Glu Asn Pro Glu Thr Asp Arg Gln Ile Ile Ala Phe Arg Arg Ala Leu

170 175 180gcg ctc gcc cgc aag cac ggg ctt gag tgc ccg gtc aac cac gta tgc 691Ala Leu Ala Arg Lys His Gly Leu Glu Cys Pro Val Asn His Val Cys

185 190 195aac tca cct gca ttc ttg act cga tct gat tta cac atg gag atg gtc 739Asn Ser Pro Ala Phe Leu Thr Arg Ser Asp Leu His Met Glu Met Val

200 205 210cga ccg ggt ttg gcc ttt tat ggg ttg gaa ccc gtg gcg gga ctg gag 787Arg Pro Gly Leu Ala Phe Tyr Gly Leu Glu Pro Val Ala Gly Leu Glu

215 220 225cat ggt ttg aag ccg gcg atg acg tgg gag gcg aag gtg agc gtc gta 835His Gly Leu Lys Pro Ala Met Thr Trp Glu Ala Lys Val Ser Val Val230 235 240 245aag caa att gaa gct gga caa ggc act tcc tat ggc ctg acc tgg cgc 883Lys Gln Ile Glu Ala Gly Gln Gly Thr Ser Tyr Gly Leu Thr Trp Arg

250 255 260gct gag gat cgc ggc ttt gtg gct gtg gtg cct gcg ggc tat gcc gat 931Ala Glu Asp Arg Gly Phe Val Ala Val Val Pro Ala Gly Tyr Ala Asp

265 270 275ggc atg ccg cgg cat gcc cag ggg aaa ttc tcc gtc acg att gat ggc 979Gly Met Pro Arg His Ala Gln Gly Lys Phe Ser Val Thr Ile Asp Gly

280 285 290ctg gac tat ccg cag gtt ggg cgc gta tgc atg gat cag ttc gtt att 1027Leu Asp Tyr Pro Gln Val Gly Arg Val Cys Met Asp Gln Phe Val Ile

295 300 305tct ttg ggc gac aat cca cac ggc gtg gaa gct ggg gcg aag gcc gtg 1075Ser Leu Gly Asp Asn Pro His Gly Val Glu Ala Gly Ala Lys Ala Val310 315 320 325ata ttc ggt gag aat ggg cat gac gca act gat ttt gcg gag cgt tta 1123Ile Phe Gly Glu Asn Gly His Asp Ala Thr Asp Phe Ala Glu Arg Leu

330 335 340gac acc att aac tat gag gta gtg tgc cga cca acc ggc cga act gtc 1171Asp Thr Ile Asn Tyr Glu Val Val Cys Arg Pro Thr Gly Arg Thr Val

345 350 355cgc gca tat gtt taagtgaata cgtttaagga gca 1206Arg Ala Tyr Val

360<210>130<211>361<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>130Met Asn Leu Leu Thr Thr Lys Ile Asp Leu Asp Ala Ile Ala His Asn 151015 Thr Arg Val Leu Lys Gln Met Ala Gly Pro Ala Lys Leu Met Ala Val

20 25 30Val Lys Ala Asn Ala Tyr Asn His Gly Val Glu Lys Val Ala Pro Val

35 40 45Ile Ala Ala His Gly Ala Asp Ala Phe Gly Val Ala Thr Leu Ala Glu

50 55 60Ala Met Gln Leu Arg Asp Ile Gly Ile Ser Gln Glu Val Leu Cys Trp 65 70 75 80Ile Trp Thr Pro Glu Gln Asp Phe Arg Ala Ala Ile Asp Arg Asn Ile

85 90 95Asp Leu Ala Val Ile Ser Pro Ala His Ala Lys Ala Leu Ile Glu Thr

100 105 110Asp Ala Glu His Ile Arg Val Ser Ile Lys Ile Asp Ser Gly Leu His

115 120 125Arg Ser Gly Val Asp Glu Gln Glu Trp Glu Gly Val Phe Ser Ala Leu

130 135 140Ala Ala Ala Pro His Ile Glu Val Thr Gly Met Phe Thr His Leu Ala145 150 155 160Cys Ala Asp Glu Pro Glu Asn Pro Glu Thr Asp Arg Gln Ile Ile Ala

165 170 175Phe Arg Arg Ala Leu Ala Leu Ala Arg Lys His Gly Leu Glu Cys Pro

180 185 190Val Asn His Val Cys Asn Ser Pro Ala Phe Leu Thr Arg Ser Asp Leu

195 200 205His Met Glu Met Val Arg Pro Gly Leu Ala Phe Tyr Gly Leu Glu Pro

210 215 220Val Ala Gly Leu Glu His Gly Leu Lys Pro Ala Met Thr Trp Glu Ala225 230 235 240Lys Val Ser Val Val Lys Gln Ile Glu Ala Gly Gln Gly Thr Ser Tyr

245 250 255Gly Leu Thr Trp Arg Ala Glu Asp Arg Gly Phe Val Ala Val Val Pro

260 265 270Ala Gly Tyr Ala Asp Gly Met Pro Arg His Ala Gln Gly Lys Phe Ser

275 280 285Val Thr Ile Asp Gly Leu Asp Tyr Pro Gln Val Gly Arg Val Cys Met

290 295 300Asp GlnPhe Val Ile Ser Leu Gly Asp Asn Pro His Gly Val Glu Ala305 310 315 320Gly Ala Lys Ala Val Ile Phe Gly Glu Asn Gly His Asp Ala Thr Asp

325 330 335Phe Ala Glu Arg Leu Asp Thr Ile Asn Tyr Glu Val Val Cys Arg Pro

340 345 350Thr Gly Arg Thr Val Arg Ala Tyr Val

355360<210>131<211>1152<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1129)<223>RXN00636<400>131tcatgggatt cagcaaggcg gccacccgaa ccgtctttgg tggaggagta ggagcgatga 60tcgatctggc ccgttcgaac ataaggaata ttcctactcc atg atg att gat aca 115

Met Met Ile Asp Thr

1 5cct gct gtt ctc att gac cgc gag cgc tta act gcc aac att tcc agg 163Pro Ala Val Leu Ile Asp Arg Glu Arg Leu Thr Ala Asn Ile Ser Arg

10 15 20atg gca gct cac gcc ggt gcc cat gag att gcc ctg cgt ccg cat gtg 211Met Ala Ala His Ala Gly Ala His Glu Ile Ala Leu Arg Pro His Val

25 30 35aaa acg cac aaa atc att gaa att gcg cag atg cag gtc gac gcc ggt 259Lys Thr His Lys Ile Ile Glu Ile Ala Gln Met Gln Val Asp Ala Gly

40 45 50gcc cga ggg atc acc tgc gca acc att ggc gag gcg gaa att ttt gcc 307Ala Arg Gly Ile Thr Cys Ala Thr Ile Gly Glu Ala Glu Ile Phe Ala

55 60 65ggc gca ggt ttt acg gac atc ttt att gca tat ccg ctg tat cta acc 355Gly Ala Gly Phe Thr Asp Ile Phe Ile Ala Tyr Pro Leu Tyr Leu Thr 70 75 80 85gat cat gca gtg caa cgc ctg aac gcg atc ccc gga gaa att tcc att 403Asp His Ala Val Gln Arg Leu Asn Ala Ile Pro Gly Glu Ile Ser Ile

90 95 100ggc gtg gat tcg gta gag atg gca cag gcg acg gcg ggt ttg cgg gaa 451Gly Val Asp Ser Val Glu Met Ala Gln Ala Thr Ala Gly Leu Arg Glu

105 110 115gat atc aag gct ctg att gaa gtg gat tcg gga cat cgt aga agt gga 499Asp Ile Lys Ala Leu Ile Glu Val Asp Ser Gly His Arg Arg Ser Gly

120 125 130gtc acg gcg act gct tca gaa ttg agt cag atc cgc gag gcg ctg ggc 547Val Thr Ala Thr Ala Ser Glu Leu Ser Gln Ile Arg Glu Ala Leu Gly

135 140 145agc agg tat gca gga gtg ttt act ttt cct ggg cat tct tat ggc ccg 595Ser Arg Tyr Ala Gly Val Phe Thr Phe Pro Gly His Ser Tyr Gly Pro150 155 160 165gga aat ggt gag cag gca gca gct gat gag ctt cag gct cta aac aac 643Gly Asn Gly Glu Gln Ala Ala Ala Asp Glu Leu Gln Ala Leu Asn Asn

170 175 180agc gtc cag cga ctt gct ggc ggc ctg act tct ggc ggt tcc tcg ccg 691Ser Val Gln Arg Leu Ala Gly Gly Leu Thr Ser Gly Gly Ser Ser Pro

185 190 195tct gcg cag ttt aca gac gca atc gat gag atg cga cca ggc gtg tat 739Ser Ala Gln Phe Thr Asp Ala Ile Asp Glu Met Arg Pro Gly Val Tyr

200 205 210gtg ttt aac gat tcc cag cag atc acc tcg gga gca tgc act gag aag 787Val Phe Asn Asp Ser Gln Gln Ile Thr Ser Gly Ala Cys Thr Glu Lys

215 220 225cag gtg gca atg acg gtg ctg tct act gtg gtc agc cga aat gtg tca 835Gln Val Ala Met Thr Val Leu Ser Thr Val Val Ser Arg Asn Val Ser230 235 240 245gat cgt cgg atc att ttg gat gcg gga tcc aaa atc ctc agc act gat 883Asp Arg Arg Ile Ile Leu Asp Ala Gly Ser Lys Ile Leu Ser Thr Asp

250 255 260aaa cca gca tgg att gat ggc aat ggt ttt gtt ctg ggg aat cct gaa 931Lys Pro Ala Trp Ile Asp Gly Asn Gly Phe Val Leu Gly Asn Pro Glu

265 270 275gcc cga atc tct gct ttg tcg gag cat cac gca acc att ttc tgg cca 979Ala Arg Ile Ser Ala Leu Ser Glu His His Ala Thr Ile Phe Trp Pro

280 285 290gat aaa gtg cta ctt cca gta atc ggg gag cag ctc aac atc gtg ccc 1027Asp Lys Val Leu Leu Pro Val Ile Gly Glu Gln Leu Asn Ile Val Pro

295 300 305aac cat gcc tgc aac gtg att aat ttg gtg gat gag gtc tac gtt cgg 1075Asn His Ala Cys Asn Val Ile Asn Leu Val Asp Glu Val Tyr Val Arg310 315 320 325gaa gcc gat ggc act ttc cgt acc tgg aag gta gtt gcc cgc ggc aga 1123Glu Ala Asp Gly Thr Phe Arg Thr Trp Lys Val Val Ala Arg Gly Arg

330335340 aac aat tagggaaacc tcttgacctt cac 1152Asn Asn<210>132<211>343<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>132Met Met Ile Asp Thr Pro Ala Val Leu Ile Asp Arg Glu Arg Leu Thr 151015 Ala Asn Ile Ser Arg Met Ala Ala His Ala Gly Ala His Glu Ile Ala

20 25 30Leu Arg Pro His Val Lys Thr His Lys Ile Ile Glu Ile Ala Gln Met

35 40 45Gln Val Asp Ala Gly Ala Arg Gly Ile Thr Cys Ala Thr Ile Gly Glu

50 55 60Ala Glu Ile Phe Ala Gly Ala Gly Phe Thr Asp Ile Phe Ile Ala Tyr 65 70 75 80Pro Leu Tyr Leu Thr Asp His Ala Val Gln Arg Leu Asn Ala Ile Pro

85 90 95Gly Glu Ile Ser Ile Gly Val Asp Ser Val Glu Met Ala Gln Ala Thr

100 105 110Ala Gly Leu Arg Glu Asp Ile Lys Ala Leu Ile Glu Val Asp Ser Gly

115 120 125His Arg Arg Ser Gly Val Thr Ala Thr Ala Ser Glu Leu Ser Gln Ile

130 135 140Arg Glu Ala Leu Gly Ser Arg Tyr Ala Gly Val Phe Thr Phe Pro Gly145 150 155 160His Ser Tyr Gly Pro Gly Asn Gly Glu Gln Ala Ala Ala Asp Glu Leu

165 170 175Gln Ala Leu Asn Asn Ser Val Gln Arg Leu Ala Gly Gly Leu Thr Ser

180 185 190Gly Gly Ser Ser Pro Ser Ala Gln Phe Thr Asp Ala Ile Asp Glu Met

195 200 205Arg Pro Gly Val Tyr Val Phe Asn Asp Ser Gln Gln Ile Thr Ser Gly

210 215 220Ala Cys Thr Glu Lys Gln Val Ala Met Thr Val Leu Ser Thr Val Val225 230 235 240Ser Arg Asn Val Ser Asp Arg Arg Ile Ile Leu Asp Ala Gly Ser Lys

245 250 255Ile Leu Ser Thr Asp Lys Pro Ala Trp Ile Asp Gly Asn Gly Phe Val

260 265 270Leu Gly Asn Pro Glu Ala Arg Ile Ser Ala Leu Ser Glu His His Ala

275 280 285Thr Ile Phe Trp Pro Asp Lys Val Leu Leu Pro Val Ile Gly Glu Gln

290 295 300Leu Asn Ile Val Pro Asn His Ala Cys Asn Val Ile Asn Leu Val Asp305 310 315 320Glu Val Tyr Val Arg Glu Ala Asp Gly Thr Phe Arg Thr Trp Lys Val

325 330 335Val Ala Arg Gly Arg Asn Asn

340<210>133<211>879<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (856)<223>RXA02536<400>133aagaagtgat cacgcgaacc tgtgtataac ttgcctcaaa gcgcctaggc tgtggattat 60gcgtattgcc ttgcttcaga tctcgacgaa ttccgataag atg gac aac ttc gcc 115

Met Asp Asn Phe Ala

1 5ctg ctg cgt gat gct gct gaa aaa gct gcg gaa cag ggg gct cgg gtg 163Leu Leu Arg Asp Ala Ala Glu Lys Ala Ala Glu Gln Gly Ala Arg Val

10 15 20ttg gtg ttt ccg gag gcg act tcg caa agc ttt ggt acg gga agg ctt 211Leu Val Phe Pro Glu Ala Thr Ser Gln Ser Phe Gly Thr Gly Arg Leu

25 30 35gat act cag gcg gag gag ctc gat ggc gaa ttc tcc acc gcg gta cga 259Asp Thr Gln Ala Glu Glu Leu Asp Gly Glu Phe Ser Thr Ala Val Arg

40 45 50aaa tta gcc gat gag ctg gac gtt gtc atc gtt gcg ggc atg ttc acc 307Lys Leu Ala Asp Glu Leu Asp Val Val Ile Val Ala Gly Met Phe Thr

55 60 65cct gct gac acc gtg cag cgc ggt gaa aaa acg atc tcg cgcgtc aac 355Pro Ala Asp Thr Val Gln Arg Gly Glu Lys Thr Ile Ser Arg Val Asn 70 75 80 85aac acc gtg ctg att agt ggc gct gga ttg cat cag gga tac aac aaa 403Asn Thr Val Leu Ile Ser Gly Ala Gly Leu His Gln Gly Tyr Asn Lys

90 95 100att cac aca tat gac gcg ttc ggt tat agg gaa tcc gac act gtg aaa 451Ile His Thr Tyr Asp Ala Phe Gly Tyr Arg Glu Ser Asp Thr Val Lys

105 110 115ccg ggc gat gag ctg gtt gta ttc gag gtc gac gat att aaa ttt ggt 499Pro Gly Asp Glu Leu Val Val Phe Glu Val Asp Asp Ile Lys Phe Gly

120 125 130gtg gcg aca tgc tac gat att cga ttc cca gaa cag ttc aaa gac ctc 547Val Ala Thr Cys Tyr Asp Ile Arg Phe Pro Glu Gln Phe Lys Asp Leu

135 140 145gcc cgc aac ggt gca cag ata att gtg gtt ccc acg tcg tgg caa gac 595Ala Arg Asn Gly Ala Gln Ile Ile Val Val Pro Thr Ser Trp Gln Asp150 155 160 165ggt cct gga aaa tta gaa caa tgg gaa gtc ctc cct cgc gcg cgt gca 643Gly Pro Gly Lys Leu Glu Gln Trp Glu Val Leu Pro Arg Ala Arg Ala

170 175 180ctg gat tcc acc tgc tgg atc gta gcg tgt ggg caa gcg cga ctt cca 691Leu Asp Ser Thr Cys Trp Ile Val Ala Cys Gly Gln Ala Arg Leu Pro

185 190 195gaa gaa tta cgc gat gaa cga aaa ggc cct acg ggg att ggt cat tcc 739Glu Glu Leu Arg Asp Glu Arg Lys Gly Pro Thr Gly Ile Gly His Ser

200 205 210atg gtg aca aac cca cac ggt gaa gta att gct agc gcg ggt tat gag 787Met Val Thr Asn Pro His Gly Glu Val Ile Ala Ser Ala Gly Tyr Glu

215 220 225cca gaa atg ttg atc gcg gat att gat gtc agc ggt ttg gcc aaa att 835Pro Glu Met Leu Ile Ala Asp Ile Asp Val Ser Gly Leu Ala Lys Ile230 235 240 245cgg gag gca ttg cct gtt ctt taaccactgt ctaaggaatc act 879Arg Glu Ala Leu Pro Val Leu

250<210>134<211>252<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>134Met Asp Asn Phe Ala Leu Leu Arg Asp Ala Ala Glu Lys Ala Ala Glu 151015 Gln Gly Ala Arg Val Leu Val Phe Pro Glu Ala Thr Ser Gln Ser Phe

20 25 30Gly Thr Gly Arg Leu Asp Thr Gln Ala Glu Glu Leu Asp Gly Glu Phe

35 40 45Ser Thr Ala Val Arg Lys Leu Ala Asp Glu Leu Asp Val Val Ile Val

50 55 60Ala Gly Met Phe Thr Pro Ala Asp Thr Val Gln Arg Gly Glu Lys Thr 65 70 75 80Ile Ser Arg Val Asn Asn Thr Val Leu Ile Ser Gly Ala Gly Leu His

85 90 95Gln Gly Tyr Asn Lys Ile His Thr Tyr Asp Ala Phe Gly Tyr Arg Glu

100 105 110Ser Asp Thr Val Lys Pro Gly Asp Glu Leu Val Val Phe Glu Val Asp

115 120 125Asp Ile Lys Phe Gly Val Ala Thr Cys Tyr Asp Ile Arg Phe Pro Glu

130 135 140Gln Phe Lys Asp Leu Ala Arg Asn Gly Ala Gln Ile Ile Val Val Pro145 150 155 160Thr Ser Trp Gln Asp Gly Pro Gly Lys Leu Glu Gln Trp Glu Val Leu

165 170 175Pro Arg Ala Arg Ala Leu Asp Ser Thr Cys Trp Ile Val Ala Cys Gly

180 185 190Gln Ala Arg Leu Pro Glu Glu Leu Arg Asp Glu Arg Lys Gly Pro Thr

195 200 205Gly Ile Gly His Ser Met Val Thr Asn Pro His Gly Glu Val Ile Ala

210 215 220Ser Ala Gly Tyr Glu Pro Glu Met Leu Ile Ala Asp Ile Asp Val Ser225 230 235 240Gly Leu Ala Lys Ile Arg Glu Ala Leu Pro Val Leu

245250<210>135<211>1635<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1612)<223>RXS00870<400>135caagacggcg atgtcgccgc cgctgttgat accgcagcgc gacttgttca cacagatatt 60caacaattca cttcgcagag catttaagga atttacacac atg tct gaa cca caa 115

Met Ser Glu Pro Gln

1 5acc atc tcg cac tgg att gac ggc gcg att tcc cca tcc act tcc ggc 163Thr Ile Ser His Trp Ile Asp Gly Ala Ile Ser Pro Ser Thr Ser Gly

10 15 20aag acc gct cct gtc tac aat cct gca act ggc cag gtc acc gcc aat 211Lys Thr Ala Pro Val Tyr Asn Pro Ala Thr Gly Gln Val Thr Ala Asn

25 30 35gtt gcg ctg gct agc cag gaa gag atc gat gcc acc atc gct tct gcc 259Val Ala Leu Ala Ser Gln Glu Glu Ile Asp Ala Thr Ile Ala Ser Ala

40 45 50acc aag gct gct aag acg tgg ggc aac ctg tct atc gct aag cgc caa 307Thr Lys Ala Ala Lys Thr Trp Gly Asn Leu Ser Ile Ala Lys Arg Gln

55 6065gct gtg ctt ttc aac ttc cgt gag ctg ctg aat gct cgc aag ggt gag 355Ala Val Leu Phe Asn Phe Arg Glu Leu Leu Asn Ala Arg Lys Gly Glu 70 75 80 85ctg gcg gag atc atc act gca gag cac ggc aag gtc ttg tcc gat gcc 403Leu Ala Glu Ile Ile Thr Ala Glu His Gly Lys Val Leu Ser Asp Ala

90 95 100atg ggt gaa atc ctg cgc ggc cag gaa gtc gtg gag ctt gct acc ggt 451Met Gly Glu Ile Leu Arg Gly Gln Glu Val Val Glu Leu Ala Thr Gly

105 110 115ttc cca cac ctg ctt aaa ggt gcg ttc aac gag aac gtc tcc acc ggc 499Phe Pro His Leu Leu Lys Gly Ala Phe Asn Glu Asn Val Ser Thr Gly

120 125 130att gat gtg tat tcc ttg aag cag cca ctg ggt gtt gtc ggt atc atc 547Ile Asp Val Tyr Ser Leu Lys Gln Pro Leu Gly Val Val Gly Ile Ile

135 140 145agc ccg ttc aac ttc cct gcg atg gtg ccg atg tgg ttt ttc cca atc 595Ser Pro Phe Asn Phe Pro Ala Met Val Pro Met Trp Phe Phe Pro Ile150 155 160 165gca atc gct gca ggc aac gca gtt att ttg aag cct tca gag aag gat 643Ala Ile Ala Ala Gly Asn Ala Val Ile Leu Lys Pro Ser Glu Lys Asp

170 175 180cct tcg gca gcg ctg tgg atg gct cag atc tgg aag gaa gct ggt ctt 691Pro Ser Ala Ala Leu Trp Met Ala Gln Ile Trp Lys Glu Ala Gly Leu

185 190 195cca gac ggc gta ttc aac gtg ctc cag ggc gac aag ctg gct gtt gat 739Pro Asp Gly Val Phe Asn Val Leu Gln Gly Asp Lys Leu Ala Val Asp

200 205 210ggt ttg ctg aac agc cct gat gtc tct gcg att tcc ttc gtg ggt tcc 787Gly Leu Leu Asn Ser Pro AspVal Ser Ala Ile Ser Phe Val Gly Ser

215 220 225acc cca atc gca aag tac atc tac gag act tcc gcg aag aac ggc aag 835Thr Pro Ile Ala Lys Tyr Ile Tyr Glu Thr Ser Ala Lys Asn Gly Lys230 235 240 245cgc gtc cag gcg ttg ggc ggc gcg aag aac cac atg ctg gtg ctg cca 883Arg Val Gln Ala Leu Gly Gly Ala Lys Asn His Met Leu Val Leu Pro

250 255 260gat gct gat ctg gat ctg gtt gcc gat cag gca atc aac gca ggt tac 931Asp Ala Asp Leu Asp Leu Val Ala Asp Gln Ala Ile Asn Ala Gly Tyr

265 270 275ggc gct gcc ggt gag cgt tgc atg gct gtt tct gtg gtc ttg gct att 979Gly Ala Ala Gly Glu Arg Cys Met Ala Val Ser Val Val Leu Ala Ile

280 285 290gaa tct gtt gcc gac gag ctc att gag aag atc aag gag cgc atc gac 1027Glu Ser Val Ala Asp Glu Leu Ile Glu Lys Ile Lys Glu Arg Ile Asp

295 300 305acc ctg cgc atc ggc aac ggt gcc ggc gac gag cag ggc gag ccg cac 1075Thr Leu Arg Ile Gly Asn Gly Ala Gly Asp Glu Gln Gly Glu Pro His310 315 320 325ctg ggc cca cta atc acc gac gtc cac cgc gac aag gtc gct tct tat 1123Leu Gly Pro Leu Ile Thr Asp Val His Arg Asp Lys Val Ala Ser Tyr

330 335 340gtc gac atc gct gag gcc gac ggc gcc aag atc atc gtg gac ggg cgt 1171Val Asp Ile Ala Glu Ala Asp Gly Ala Lys Ile Ile Val Asp Gly Arg

345 350 355aac tgc gcc gta gac ggg cac gag gag ggc ttc ttc ttc ggc cct acg 1219Asn Cys Ala Val Asp Gly His Glu Glu Gly Phe Phe Phe Gly Pro Thr

360 365 370ctt atc gac gac atc cca ctc acg ttc cgc gcc tac acc gaa gaa atc 1267Leu Ile Asp Asp Ile Pro Leu Thr Phe Arg Ala Tyr Thr Glu Glu Ile

375 380 385ttc ggc ccg gtc ctc tct gtc gtt cgt gtc gca tcc ttc gac gag gca 1315Phe Gly Pro Val Leu Ser Val Val Arg Val Ala Ser Phe Asp Glu Ala390 395 400 405att gag ctg atc aac tcc ggt gaa ttc ggc aac gga acc gca atc ttc 1363Ile Glu Leu Ile Asn Ser Gly Glu Phe Gly Asn Gly Thr Ala Ile Phe

410 415 420acc aac gat ggt gga gcg gca cgc cgc ttc cag cat gag atc gaa gtg 1411Thr Asn Asp Gly Gly Ala Ala Arg Arg Phe Gln His Glu Ile Glu Val

425 430 435ggc atg atc ggc atc aac gta cca atc cca gtg cct gtt gcg tac cac 1459Gly Met Ile Gly Ile Asn Val Pro Ile Pro Val Pro Val Ala Tyr His

440 445 450tcc ttc ggt ggt tgg aag aac tcc ctc ttc ggt gac gcc aag gca tat 1507Ser Phe Gly Gly Trp Lys Asn Ser Leu Phe Gly Asp Ala Lys Ala Tyr

455 460 465ggc act caa ggt ttt gat ttc ttc acc agg gaa aag gcg atc acc agc 1555Gly Thr Gln Gly Phe Asp Phe Phe Thr Arg Glu Lys Ala Ile Thr Ser470 475 480 485cgt tgg ctc gac cca gca acc cac ggt ggc att aac ctc ggt ttc cca 1603Arg Trp Leu Asp Pro Ala Thr His Gly Gly Ile Asn Leu Gly Phe Pro

490495500 cag aac gat taattgaagg agagcacagg act 1635Gln Asn Asp<210>136<211>504<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>136Met Ser Glu Pro Gln Thr Ile Ser His Trp Ile Asp Gly Ala Ile Ser 151015 Pro Ser Thr Ser Gly Lys Thr Ala Pro Val Tyr Asn Pro Ala Thr Gly

20 2530Gln Val Thr Ala Asn Val Ala Leu Ala Ser Gln Glu Glu Ile Asp Ala

35 40 45Thr Ile Ala Ser Ala Thr Lys Ala Ala Lys Thr Trp Gly Asn Leu Ser

50 55 60Ile Ala Lys Arg Gln Ala Val Leu Phe Asn Phe Arg Glu Leu Leu Asn 65 70 75 80Ala Arg Lys Gly Glu Leu Ala Glu Ile Ile Thr Ala Glu His Gly Lys

85 90 95Val Leu Ser Asp Ala Met Gly Glu Ile Leu Arg Gly Gln Glu Val Val

100 105 110Glu Leu Ala Thr Gly Phe Pro His Leu Leu Lys Gly Ala Phe Asn Glu

115 120 125Asn Val Ser Thr Gly Ile Asp Val Tyr Ser Leu Lys Gln Pro Leu Gly

130 135 140Val Val Gly Ile Ile Ser Pro Phe Asn Phe Pro Ala Met Val Pro Met145 150 155 160Trp Phe Phe Pro Ile Ala Ile Ala Ala Gly Asn Ala Val Ile Leu Lys

165 170 175Pro Ser Glu Lys Asp Pro Ser Ala Ala Leu Trp Met Ala Gln Ile Trp

180 185 190Lys Glu Ala Gly Leu Pro Asp Gly Val Phe Asn Val Leu Gln Gly Asp

195 200 205Lys Leu Ala Val Asp Gly Leu Leu Asn Ser Pro Asp Val Ser Ala Ile

210 215 220Ser Phe Val Gly Ser Thr Pro Ile Ala Lys Tyr Ile Tyr Glu Thr Ser225 230 235 240Ala Lys Asn Gly Lys Arg Val Gln Ala Leu Gly Gly Ala Lys Asn His

245 250 255Met Leu Val Leu Pro Asp Ala Asp Leu Asp Leu Val Ala Asp Gln Ala

260 265 270Ile Asn Ala Gly Tyr Gly Ala Ala Gly Glu Arg Cys Met Ala Val Ser

275 280 285Val Val Leu Ala Ile Glu Ser Val Ala Asp Glu Leu Ile Glu Lys Ile

290 295 300Lys Glu Arg Ile Asp Thr Leu Arg Ile Gly Asn Gly Ala Gly Asp Glu305 310 315 320Gln Gly Glu Pro His Leu Gly Pro Leu Ile Thr Asp Val His Arg Asp

325 330 335Lys Val Ala Ser Tyr Val Asp Ile Ala Glu Ala Asp Gly Ala Lys Ile

340 345 350Ile Val Asp Gly Arg Asn Cys Ala Val Asp Gly His Glu Glu Gly Phe

355 360 365Phe Phe Gly Pro Thr Leu Ile Asp Asp Ile Pro Leu Thr Phe Arg Ala

370 375 380Tyr Thr Glu Glu Ile Phe Gly Pro Val Leu Ser Val Val Arg Val Ala385 390 395 400Ser Phe Asp Glu Ala Ile Glu Leu Ile Asn Ser Gly Glu Phe Gly Asn

405 410 415Gly Thr Ala Ile Phe Thr Asn Asp Gly Gly Ala Ala Arg Arg Phe Gln

420 425 430His Glu Ile Glu Val Gly Met Ile Gly Ile Asn Val Pro Ile Pro Val

435 440 445Pro Val Ala Tyr His Ser Phe Gly Gly Trp Lys Asn Ser Leu Phe Gly

450 455 460Asp Ala Lys Ala Tyr Gly Thr Gln Gly Phe Asp Phe Phe Thr Arg Glu465 470 475 480Lys Ala Ile Thr Ser Arg Trp Leu Asp Pro Ala Thr His Gly Gly Ile

485 490 495Asn Leu Gly Phe Pro Gln Asn Asp

500<210>137<211>531<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (508)<223>RXS02299<400>137acgcgggggt tgttgccgga tcgaaatatt cctttccttg tcatctcacg ctatgatttc 60taaaacttgc aggacaaccc ccataaggac accacaggac atg ctg cgc acc atc 115

Met Leu Arg Thr Ile

1 5ctc gga agt aag att cac cga gcc act gtc act caa gct gat cta gat 163Leu Gly Ser Lys Ile His Arg Ala Thr Val Thr Gln Ala Asp Leu Asp

10 15 20tat gtt ggc tct gta acc atc gac gcc gac ctg gtt cac gcc gcc gga 211Tyr Val Gly Ser Val Thr Ile Asp Ala Asp Leu Val His Ala Ala Gly

25 30 35ttg atc gaa ggc gaa aaa gtt gcc atc gta gac ate acc aac ggc gct 259Leu Ile Glu Gly Glu Lys Val Ala Ile Val Asp Ile Thr Asn Gly Ala

40 45 50cgt ctg gaa act tat gtc att gtg ggc gac gcc gga acg ggc aat att 307Arg Leu Glu Thr Tyr Val Ile Val Gly Asp Ala Gly Thr Gly Asn Ile

55 60 65tgc atc aat ggt gcc gct gca cac ctt att aat cct ggc gat ctt gtg 355Cys Ile Asn Gly Ala Ala Ala His Leu Ile Asn Pro Gly Asp Leu Val 70 75 80 85atc atc atg agc tac ctt cag gca act gat gcg gaa gcc aag gcg tat 403Ile Ile Met Ser Tyr Leu Gln Ala Thr Asp Ala Glu Ala Lys Ala Tyr

90 95 100gag cca aag att gtg cac gtg gac gcc gac aac cgc atc gtt gcg ctc 451Glu Pro Lys Ile Val His Val Asp Ala Asp Asn Arg Ile Val Ala Leu

105 110 115ggc aac gat ctt gcg gaa gca cta cct gga tcc ggg ctt ttg acg tcg 499Gly Asn Asp Leu Ala Glu Ala Leu Pro Gly Ser Gly Leu Leu Thr Ser

120 125 130aga agc att tagcgtttta gctcgccaat att 531Arg Ser Ile

135<210>138<211>136<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>138Met Leu Arg Thr Ile Leu Gly Ser Lys Ile His Arg Ala Thr Val Thr 151015 Gln Ala Asp Leu Asp Tyr Val Gly Ser Val Thr Ile Asp Ala Asp Leu

20 25 30Val His Ala Ala Gly Leu Ile Glu Gly Glu Lys Val Ala Ile Val Asp

35 40 45Ile Thr Asn Gly Ala Arg Leu Glu Thr Tyr Val Ile Val Gly Asp Ala

50 55 60Gly Thr Gly Asn Ile Cys Ile Asn Gly Ala Ala Ala His Leu Ile Asn 65 70 75 80Pro Gly Asp Leu Val Ile Ile Met Ser Tyr Leu Gln Ala Thr Asp Ala

85 90 95Glu Ala Lys Ala Tyr Glu Pro Lys Ile Val His Val Asp Ala Asp Asn

100 105 110Arg Ile Val Ala Leu Gly Asn Asp Leu Ala Glu Ala Leu Pro Gly Ser

115 120 125Gly Leu Leu Thr Ser Arg Ser Ile

130135<210>139<211>1053<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1030)<223>RXA01561<400>139gtgcccagaa attctgcttg cactcaccca agccgtttag caaattgaac ctcacgttca 60taataatgtt cattttcatc gagttctaga aaacacaggc atg ctc acc ctc aac 115

Met Leu Thr Leu Asn

1 5gat gtc atc acc gcc caa caa cga acc gcc cct cat gtt cga cga acg 163Asp Val Ile Thr Ala Gln Gln Arg Thr Ala Pro His Val Arg Arg Thr

10 15 20cca ctt ttc gaa gca gac ccc atc gac ggc aca caa atc tgg atc aaa 211Pro Leu Phe Glu Ala Asp Pro Ile Asp Gly Thr Gln Ile Trp Ile Lys

25 30 35gca gag ttc ctc caa aag tgc ggc gtg ttc aaa acg cgt gga gca ttc 259Ala Glu Phe Leu Gln Lys Cys Gly Val Phe Lys Thr Arg Gly Ala Phe

40 45 50aac cgc cag ctc gca gct tcg gaa aac gga cta ctc gac cca acg gtt 307Asn Arg Gln Leu Ala Ala Ser Glu Asn Gly Leu Leu Asp Pro Thr Val

55 60 65ggc atc gtc gcg gca tca ggc gga aac gca gga ctc gca aat gct ttt 355Gly Ile Val Ala Ala Ser Gly Gly Asn Ala Gly Leu Ala Asn Ala Phe70 75 80 85gcc gca gca tcc tta agc gtt ccc gcc acg gta ttg gtg ccc gaa act 403Ala Ala Ala Ser Leu Ser Val Pro Ala Thr Val Leu Val Pro Glu Thr

90 95 100gcc cca caa gta aaa gtt gat cgc ctc aag caa tac ggt gca acc gtg 451Ala Pro Gln Val Lys Val Asp Arg Leu Lys Gln Tyr Gly Ala Thr Val

105 110 115caa caa atc gga tct gaa tat gcg gaa gca ttt gag gca gct caa acc 499Gln Gln Ile Gly Ser Glu Tyr Ala Glu Ala Phe Glu Ala Ala Gln Thr

120 125 130ttt gag tcg gaa act ggt gct ctg ttt tgc cac gcc tac gac cag ccc 547Phe Glu Ser Glu Thr Gly Ala Leu Phe Cys His Ala Tyr Asp Gln Pro

135 140 145gac atc gca gct gga gca ggc gtc att ggg cta gaa att gtc gaa gat 595Asp Ile Ala Ala Gly Ala Gly Val Ile Gly Leu Glu Ile Val Glu Asp150 155 160 165ctt ccc gac gtt gac acc atc gtg gtt gct gtc ggt ggc ggt gga ctc 643Leu Pro Asp Val Asp Thr Ile Val Val Ala Val Gly Gly Gly Gly Leu

170 175 180tat gca gga atc gca gcc gtc gta gca gcc cac gac atc aaa gtg gtg 691Tyr Ala Gly Ile Ala Ala Val Val Ala Ala His Asp Ile Lys Val Val

185 190 195gcc gtt gaa ccc tcc aaa att cca acc ctg cac aac tca ctc att gcc 739Ala Val Glu Pro Ser Lys Ile Pro Thr Leu His Asn Ser Leu Ile Ala

200 205 210ggc caa cca gtc gat gtg aac gtt tct ggt atc gcg gca gat tct ttg 787Gly Gln Pro Val Asp Val Asn Val Ser Gly Ile Ala Ala Asp Ser Leu

215 220 225ggg gct cgc caa att gga cga gaa gcc ttt gac atc gca act gcc cat 835Gly Ala Arg Gln Ile Gly Arg Glu Ala Phe Asp Ile Ala Thr Ala His230 235 240 245ccc cca ata ggc gtc cta gtg gac gat gaa gca atc atc gca gct cga 883Pro Pro Ile Gly Val Leu Val Asp Asp Glu Ala Ile Ile Ala Ala Arg

250 255 260cgc cac ctc tgg gac aac tac cgc atc cct gcc gag cat ggc gct gcc 931Arg His Leu Trp Asp Asn Tyr Arg Ile Pro Ala Glu His Gly Ala Ala

265 270 275gca gca ctc gcc tct ctt acc agt gga gca tac aaa cctgca gca gat 979Ala Ala Leu Ala Ser Leu Thr Ser Gly Ala Tyr Lys Pro Ala Ala Asp

280 285 290gaa aaa gtg gca gtc att gtg tgc gga gcg aac act gac ctc aca aca 1027Glu Lys Val Ala Val Ile Val Cys Gly Ala Asn Thr Asp Leu Thr Thr

295300305 ctg tgatgtgatt tcaaacgatc aca 1053Leu310<210>140<211>310<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>140Met Leu Thr Leu Asn Asp Val Ile Thr Ala Gln Gln Arg Thr Ala Pro 151015 His Val Arg Arg Thr Pro Leu Phe Glu Ala Asp Pro Ile Asp Gly Thr

20 25 30Gln Ile Trp Ile Lys Ala Glu Phe Leu Gln Lys Cys Gly Val Phe Lys

35 40 45Thr Arg Gly Ala Phe Asn Arg Gln Leu Ala Ala Ser Glu Asn Gly Leu

50 55 60Leu Asp Pro Thr Val Gly Ile Val Ala Ala Ser Gly Gly Asn Ala Gly 65 70 75 80Leu Ala Asn Ala Phe Ala Ala Ala Ser Leu Ser Val Pro Ala Thr Val

85 90 95Leu Val Pro Glu Thr Ala Pro Gln Val Lys Val Asp Arg Leu Lys Gln

100 105 110Tyr Gly Ala Thr Val Gln Gln Ile Gly Ser Glu Tyr Ala Glu Ala Phe

115 120 125Glu Ala Ala Gln Thr Phe Glu Ser Glu Thr Gly Ala Leu Phe Cys His

130 135 140Ala Tyr Asp Gln Pro Asp Ile Ala Ala Gly Ala Gly Val Ile Gly Leu145 150 155 160Glu Ile Val Glu Asp Leu Pro Asp Val Asp Thr Ile Val Val Ala Val

165 170 175Gly Gly Gly Gly Leu Tyr Ala Gly Ile Ala Ala Val Val Ala Ala His

180 185 190Asp Ile Lys Val Val Ala Val Glu Pro Ser Lys Ile Pro Thr Leu His

195 200 205Asn Ser Leu Ile Ala Gly Gln Pro Val Asp Val Asn Val Ser Gly Ile

210 215 220Ala Ala Asp Ser Leu Gly Ala Arg Gln Ile Gly Arg Glu Ala Phe Asp225 230 235 240Ile Ala Thr Ala His Pro Pro Ile Gly Val Leu Val Asp Asp Glu Ala

245 250 255Ile Ile Ala Ala Arg Arg His Leu Trp Asp Asn Tyr Arg Ile Pro Ala

260 265 270Glu His Gly Ala Ala Ala Ala Leu Ala Ser Leu Thr Ser Gly Ala Tyr

275 280 285Lys Pro Ala Ala Asp Glu Lys Val Ala Val Ile Val Cys Gly Ala Asn

290295300 Thr Asp Leu Thr Thr Leu 305310<210>141<211>1470<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1447)<223>RXA01850<400>141ttcgtgcaac ttcagactct tacggaggcg atggaccaaa aacaactaca atcaagcaga 60tcaccttgta caccaccaga gaaaaggccc accctcagcc atg gct atc agt gtt 115

Met Ala Ile Ser Val

1 5gtt gat cta ttt agc atc ggt atc gga cca tca tcc tca cat acc gtc 163Val Asp Leu Phe Ser Ile Gly Ile Gly Pro Ser Ser Ser His Thr Val

10 15 20ggc ccc atg aga gcc gcc ctc acg tat atc tct gaa ttt ccc agc tcg 211Gly Pro Met Arg Ala Ala Leu Thr Tyr Ile Ser Glu Phe Pro Ser Ser

25 30 35cat gtc gat atc acg ttg cac gga tcc ctt gcc gcc acc ggt aaa ggc 259His Val Asp Ile Thr Leu His Gly Ser Leu Ala Ala Thr Gly Lys Gly

40 45 50cac tgc act gac cgg gcg gta tta ctg ggt ctg gtg gga tgg gaa cca 307His Cys Thr Asp Arg Ala Val Leu Leu Gly Leu Val Gly Trp Glu Pro

55 60 65acg ata gtt ccc att gat gct gca ccc tca ccc ggc gcg ccg att cct 355Thr Ile Val Pro Ile Asp Ala Ala Pro Ser Pro Gly Ala Pro Ile Pro 70 75 80 85gcg aaa ggt tct gtg aac ggg cca aag gga acg gtg tcg tat tcc ctg 403Ala Lys Gly Ser Val Asn Gly Pro Lys Gly Thr Val Ser Tyr Ser Leu

90 95 100acg ttt gat cct cat cct ctt cca gaa cac ccc aat gcc gtt acc ttt 451Thr Phe Asp Pro His Pro Leu Pro Glu His Pro Asn Ala Val Thr Phe

105 110 115aaa gga tca acc aca agg act tat ttg tcg gtg ggt ggt ggg ttc att 499Lys Gly Ser Thr Thr Arg Thr Tyr Leu Ser Val Gly Gly Gly Phe Ile

120 125 130atg acg ttg gag gat ttc cgg aag ctg gac gat atc gga tca ggt gtg 547Met Thr Leu Glu Asp Phe Arg Lys Leu Asp Asp Ile Gly Ser Gly Val

135 140 145tca acc att cat cca gag gca gag gtg cct tgt cct ttt cag aag agt 595Ser Thr Ile His Pro Glu Ala Glu Val Pro Cys Pro Phe Gln Lys Ser150 155 160 165tcc caa tta ctc gca tat ggt cgc gat ttt gcg gag gtc atg aag gat 643Ser Gln Leu Leu Ala Tyr Gly Arg Asp Phe Ala Glu Val Met Lys Asp

170 175 180aat gag cgc ttaatc cac ggg gat ctt ggc aca gtg gat gcc cat ttg 691Asn Glu Arg Leu Ile His Gly Asp Leu Gly Thr Val Asp Ala His Leu

185 190 195gat cga gtg tgg cag att atg cag gag tgc gtg gca caa ggc atc gca 739Asp Arg Val Trp Gln Ile Met Gln Glu Cys Val Ala Gln Gly Ile Ala

200 205 210acg ccg ggg att tta ccg ggt ggg ttg aat gtg caa cgt cgg gcg ccg 787Thr Pro Gly Ile Leu Pro Gly Gly Leu Asn Val Gln Arg Arg Ala Pro

215 220 225cag gta cac gcg ctg att agc aac ggg gat acg tgt gag ctg ggt gct 835Gln Val His Ala Leu Ile Ser Asn Gly Asp Thr Cys Glu Leu Gly Ala230 235 240 245gat ctt gat gct gtg gag tgg gtg aat ctg tac gcc ttg gcg gtg aat 883Asp Leu Asp Ala Val Glu Trp Val Asn Leu Tyr Ala Leu Ala Val Asn

250 255 260gaa gaa aac gcc gct ggt ggt cgt gtg gtt act gct ccg act aat ggt 931Glu Glu Asn Ala Ala Gly Gly Arg Val Val Thr Ala Pro Thr Asn Gly

265 270 275gct gcg ggg att att ccg gcg gtg atg cac tat gcg cgg gat ttt ttg 979Ala Ala Gly Ile Ile Pro Ala Val Met His Tyr Ala Arg Asp Phe Leu

280 285 290aca ggt ttt ggg gcg gag cag gcg cgg acg ttt ttg tat acc gcg ggt 1027Thr Gly Phe Gly Ala Glu Gln Ala Arg Thr Phe Leu Tyr Thr Ala Gly

295 300 305gcg gtg ggc atc atc att aag gaa aat gcc tcg atc tct ggc gcg gag 1075Ala Val Gly Ile Ile Ile Lys Glu Asn Ala Ser Ile Ser Gly Ala Glu310 315 320 325gtg ggg tgt cag ggt gag gtt ggt tca gcg tcc gcg atg gcg gct gcc 1123Val Gly Cys Gln Gly Glu Val Gly Ser Ala Ser Ala Met Ala Ala Ala

330 335 340ggg ttg tgt gca gtc tta ggt ggt tct ccg caa cag gtg gaa aac gcc 1171Gly Leu Cys Ala Val Leu Gly Gly Ser Pro Gln Gln Val Glu Asn Ala

345 350 355gcg gag att gcg ttg gag cac aat ttg gga ttg acg tgc gat ccg gtg 1219Ala Glu Ile Ala Leu Glu His Asn Leu Gly Leu Thr Cys Asp Pro Val

360 365 370ggc ggg tta gtg cag att ccg tgt att gaa cgc aac gct att gct gcc 1267Gly Gly Leu Val Gln Ile Pro Cys Ile Glu Arg Asn Ala Ile Ala Ala

375 380 385atg aag tcc atc aat gcg gca agg ctt gcc cgg att ggt gat ggc aac 1315Met Lys Ser Ile Asn Ala Ala Arg Leu Ala Arg Ile Gly Asp Gly Asn390 395 400 405aat cgc gtg agt ttg gat gat gtg gtg gtc acg atg gct gcc acc ggc 1363Asn Arg Val Ser Leu Asp Asp Val Val Val Thr Met Ala Ala Thr Gly

410 415 420cgg gac atg ctg acc aaa tat aag gaa acg tcc ctt ggt ggt ttg gca 1411Arg Asp Met Leu Thr Lys Tyr Lys Glu Thr Ser Leu Gly Gly Leu Ala

425 430 435acc acc ttg ggc ttc ccg gtg tcg atg acg gag tgt tagcggtacg 1457Thr Thr Leu Gly Phe Pro Val Ser Met Thr Glu Cys

440445 gctttaacac ggc 1470<210>142<211>449<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>142Met Ala Ile Ser Val Val Asp Leu Phe Ser Ile Gly Ile Gly Pro Ser 151015 Ser Ser His Thr Val Gly Pro Met Arg Ala Ala Leu Thr Tyr Ile Ser

20 25 30Glu Phe Pro Ser Ser His Val Asp Ile Thr Leu His Gly Ser Leu Ala

3540 45Ala Thr Gly Lys Gly His Cys Thr Asp Arg Ala Val Leu Leu Gly Leu

50 55 60Val Gly Trp Glu Pro Thr Ile Val Pro Ile Asp Ala Ala Pro Ser Pro 65 70 75 80Gly Ala Pro Ile Pro Ala Lys Gly Ser Val Asn Gly Pro Lys Gly Thr

85 90 95Val Ser Tyr Ser Leu Thr Phe Asp Pro His Pro Leu Pro Glu His Pro

100 105 110Asn Ala Val Thr Phe Lys Gly Ser Thr Thr Arg Thr Tyr Leu Ser Val

115 120 125Gly Gly Gly Phe Ile Met Thr Leu Glu Asp Phe Arg Lys Leu Asp Asp

130 135 140Ile Gly Ser Gly Val Ser Thr Ile His Pro Glu Ala Glu Val Pro Cys145 150 155 160Pro Phe Gln Lys Ser Ser Gln Leu Leu Ala Tyr Gly Arg Asp Phe Ala

165 170 175Glu Val Met Lys Asp Asn Glu Arg Leu Ile His Gly Asp Leu Gly Thr

180 185 190Val Asp Ala His Leu Asp Arg Val Trp Gln Ile Met Gln Glu Cys Val

195 200 205Ala Gln Gly Ile Ala Thr Pro Gly Ile Leu Pro Gly Gly Leu Asn Val

210 215 220Gln Arg Arg Ala Pro Gln Val His Ala Leu Ile Ser Asn Gly Asp Thr225 230 235 240Cys Glu Leu Gly Ala Asp Leu Asp Ala Val Glu Trp Val Asn Leu Tyr

245 250 255Ala Leu Ala Val Asn Glu Glu Asn Ala Ala Gly Gly Arg Val Val Thr

260 265270Ala Pro Thr Asn Gly Ala Ala Gly Ile Ile Pro Ala Val Met His Tyr

275 280 285Ala Arg Asp Phe Leu Thr Gly Phe Gly Ala Glu Gln Ala Arg Thr Phe

290 295 300Leu Tyr Thr Ala Gly Ala Val Gly Ile Ile Ile Lys Glu Asn Ala Ser305 310 315 320Ile Ser Gly Ala Glu Val Gly Cys Gln Gly Glu Val Gly Ser Ala Ser

325 330 335Ala Met Ala Ala Ala Gly Leu Cys Ala Val Leu Gly Gly Ser Pro Gln

340 345 350Gln Val Glu Asn Ala Ala Glu Ile Ala Leu Glu His Asn Leu Gly Leu

355 360 365Thr Cys Asp Pro Val Gly Gly Leu Val Gln Ile Pro Cys Ile Glu Arg

370 375 380Asn Ala Ile Ala Ala Met Lys Ser Ile Asn Ala Ala Arg Leu Ala Arg385 390 395 400Ile Gly Asp Gly Asn Asn Arg Val Ser Leu Asp Asp Val Val Val Thr

405 410 415Met Ala Ala Thr Gly Arg Asp Met Leu Thr Lys Tyr Lys Glu Thr Ser

420 425 430Leu Gly Gly Leu Ala Thr Thr Leu Gly Phe Pro Val Ser Met Thr Glu

435440445 Cys<210>143<211>1425<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).)

Met Thr Asp Ala His

1 5caa gcg gac gat gtc cgt tac cag cca ctg aac gag ctt gat cct gag 163Gln Ala Asp Asp Val Arg Tyr Gln Pro Leu AsnGlu Leu Asp Pro Glu

10 15 20gtg gct gct gcc atc gct ggg gaa ctt gcc cgt caa cgc gat aca tta 211Val Ala Ala Ala Ile Ala Gly Glu Leu Ala Arg Gln Arg Asp Thr Leu

25 30 35gag atg atc gcg tct gag aac ttc gtt ccc cgt tct gtt ttg cag gcg 259Glu Met Ile Ala Ser Glu Asn Phe Val Pro Arg Ser Val Leu Gln Ala

40 45 50cag ggt tct gtt ctt acc aat aag tat gcc gag ggt tac cct ggc cgc 307Gln Gly Ser Val Leu Thr Asn Lys Tyr Ala Glu Gly Tyr Pro Gly Arg

55 60 65cgt tac tac ggt ggt tgc gaa caa gtt gac atc att gag gat ctt gca 355Arg Tyr Tyr Gly Gly Cys Glu Gln Val Asp Ile Ile Glu Asp Leu Ala 70 75 80 85cgt gat cgt gcg aag gct ctc ttc ggt gca gag ttc gcc aat gtt cag 403Arg Asp Arg Ala Lys Ala Leu Phe Gly Ala Glu Phe Ala Asn Val Gln

90 95 100cct cac tct ggc gca cag gct aat gct gct gtg ctg atg act ttg gct 451Pro His Ser Gly Ala Gln Ala Asn Ala Ala Val Leu Met Thr Leu Ala

105 110 115gag cca ggc gac aag atc atg ggt ctg tct ttg gct cat ggt ggt cac 499Glu Pro Gly Asp Lys Ile Met Gly Leu Ser Leu Ala His Gly Gly His

120 125 130ttg acc cac gga atg aag ttg aac ttc tcc gga aag ctg tac gag gtt 547Leu Thr His Gly Met Lys Leu Asn Phe Ser Gly Lys Leu Tyr Glu Val

135 140 145gtt gcg tac ggt gtt gat cct gag acc atg cgt gtt gat atg gat cag 595Val Ala Tyr Gly Val Asp Pro Glu Thr Met Arg Val Asp Met Asp Gln150 155 160 165gtt cgt gag att gct ctg aag gag cag cca aag gta att atc gct ggc 643Val Arg Glu Ile Ala Leu Lys Glu Gln Pro Lys Val Ile Ile Ala Gly

170 175 180tgg tct gca tac cct cgc cac ctt gat ttc gag gct ttc cag tct att 691Trp Ser Ala Tyr Pro Arg His Leu Asp Phe Glu Ala Phe Gln Ser Ile

185 190 195gct gcg gaa gtt ggc gcg aag ctg tgg gtc gat atg gct cac ttc gct 739Ala Ala Glu Val Gly Ala Lys Leu Trp Val Asp Met Ala His Phe Ala

200 205 210ggt ctt gtt gct gct ggt ttg cac cca agc cca gtt cct tac tct gat 787Gly Leu Val Ala Ala Gly Leu His Pro Ser Pro Val Pro Tyr Ser Asp

215 220 225gtt gtt tct tcc act gtc cac aag act ttg ggt gga cct cgt tcc ggc 835Val Val Ser Ser Thr Val His Lys Thr Leu Gly Gly Pro Arg Ser Gly230 235 240 245atc att ctg gct aag cag gag tac gcg aag aag ctg aac tct tcc gta 883Ile Ile Leu Ala Lys Gln Glu Tyr Ala Lys Lys Leu Asn Ser Ser Val

250 255 260ttc cca ggt cag cag ggt ggt cct ttg atg cac gca gtt gct gcg aag 931Phe Pro Gly Gln Gln Gly Gly Pro Leu Met His Ala Val Ala Ala Lys

265 270 275gct act tct ttg aag att gct ggc act gag cag ttc cgt gac cgt cag 979Ala Thr Ser Leu Lys Ile Ala Gly Thr Glu Gln Phe Arg Asp Arg Gln

280 285 290gct cgc acg ttg gag ggt gct cgc att ctt gct gag cgt ctg act gct 1027Ala Arg Thr Leu Glu Gly Ala Arg Ile Leu Ala Glu Arg Leu Thr Ala

295 300 305tct gat gcg aag gcc gct ggc gtg gat gtc ttg acc ggt ggc act gat 1075Ser Asp Ala Lys Ala Ala GIy Val Asp Val Leu Thr Gly Gly Thr Asp310 315 320 325gtg cac ttg gtt ttg gct gat ctg cgt aac tcc cag atg gat ggc cag 1123Val His Leu Val Leu Ala Asp Leu Arg Asn Ser Gln Met Asp Gly Gln

330 335 340cag gcg gaa gat ctg ctg cac gag gtt ggt atc act gtg aac cgt aac 1171Gln Ala Glu Asp Leu Leu His Glu Val Gly Ile Thr Val Asn Arg Asn

345 350 355gcg gtt cct ttc gat cct cgt cca cca atg gtt act tct ggt ctg cgt 1219Ala Val Pro Phe Asp Pro Arg Pro Pro Met Val Thr Ser Gly Leu Arg

360 365 370att ggt act cct gcg ctg gct acc cgt ggt ttc gat att cct gca ttc 1267Ile Gly Thr Pro Ala Leu Ala Thr Arg Gly Phe Asp Ile Pro Ala Phe

375 380 385act gag gtt gca gac atc att ggt act gct ttg gct aat ggt aag tcc 1315Thr Glu Val Ala Asp Ile Ile Gly Thr Ala Leu Ala Asn Gly Lys Ser390 395 400 405gca gac att gag tct ctg cgt ggc cgt gta gca aag ctt gct gca gat 1363Ala Asp Ile Glu Ser Leu Arg Gly Arg Val Ala Lys Leu Ala Ala Asp

410 415 420tac cca ctg tat gag ggc ttg gaa gac tgg acc atc gtc taagtttttc 1412Tyr Pro Leu Tyr Glu Gly Leu Glu Asp Trp Thr Ile Val

425430 tttgagtttt cat 1425<5<210>144<211>434<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>144Met Thr Asp Ala His Gln Ala Asp Asp Val Arg Tyr Gln Pro Leu Asn 151015 Glu Leu Asp Pro Glu Val Ala Ala Ala Ile Ala Gly Glu Leu Ala Arg

20 25 30Gln Arg Asp Thr Leu Glu Met Ile Ala Ser Glu Asn Phe Val Pro Arg

35 40 45Ser Val Leu Gln Ala Gln Gly Ser Val Leu Thr Asn Lys Tyr Ala Glu

50 55 60Gly Tyr Pro Gly Arg Arg Tyr Tyr Gly Gly Cys Glu Gln Val Asp Ile 65 70 75 80Ile Glu Asp Leu Ala Arg Asp Arg Ala Lys Ala Leu Phe Gly Ala Glu

85 90 95Phe Ala Asn Val Gln Pro His Ser Gly Ala Gln Ala Asn Ala Ala Val

100 105 110Leu Met Thr Leu Ala Glu Pro Gly Asp Lys Ile Met Gly Leu Ser Leu

115 120 125Ala His Gly Gly His Leu Thr His Gly Met Lys Leu Asn Phe Ser Gly

130 135 140Lys Leu Tyr Glu Val Val Ala Tyr Gly Val Asp Pro Glu Thr Met Arg145 150 155 160Val Asp Met Asp Gln Val Arg Glu Ile Ala Leu Lys Glu Gln Pro Lys

165 170 175Val Ile Ile Ala Gly Trp Ser Ala Tyr Pro Arg His Leu Asp Phe Glu

180 185 190Ala Phe Gln Ser Ile Ala Ala Glu Val Gly Ala Lys Leu Trp Val Asp

195 200 205Met Ala His Phe Ala Gly Leu Val Ala Ala Gly Leu His Pro Ser Pro

210 215 220Val Pro Tyr Ser Asp Val Val Ser Ser Thr Val His Lys Thr Leu Gly225 230 235 240Gly Pro Arg Ser Gly Ile Ile Leu Ala Lys Gln Glu Tyr Ala Lys Lys

245 250 255Leu Asn Ser Ser Val Phe Pro Gly Gln Gln Gly Gly Pro Leu Met His

260265 270Ala Val Ala Ala Lys Ala Thr Ser Leu Lys Ile Ala Gly Thr Glu Gln

275 280 285Phe Arg Asp Arg Gln Ala Arg Thr Leu Glu Gly Ala Arg Ile Leu Ala

290 295 300Glu Arg Leu Thr Ala Ser Asp Ala Lys Ala Ala Gly Val Asp Val Leu305 310 315 320Thr Gly Gly Thr Asp Val His Leu Val Leu Ala Asp Leu Arg Asn Ser

325 330 335Gln Met Asp Gly Gln Gln Ala Glu Asp Leu Leu His Glu Val Gly Ile

340 345 350Thr Val Asn Arg Asn Ala Val Pro Phe Asp Pro Arg Pro Pro Met Val

355 360 365Thr Ser Gly Leu Arg Ile Gly Thr Pro Ala Leu Ala Thr Arg Gly Phe

370 375 380Asp Ile Pro Ala Phe Thr Glu Val Ala Asp Ile Ile Gly Thr Ala Leu385 390 395 400Ala Asn Gly Lys Ser Ala Asp Ile Glu Ser Leu Arg Gly Arg Val Ala

405 410 415Lys Leu Ala Ala Asp Tyr Pro Leu Tyr Glu Gly Leu Glu Asp Trp Thr

420425430 Ile Val<210>145<211>401<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) } (378)<223>RXA01821<400>145cga aac agc caa ggc aaa tgg tgc cca agt acg cga tca cca aaa aat 48Arg Asn Ser Gln Gly Lys Trp Cys Pro Ser Thr Arg Ser Pro Lys Asn 151015 acc agc atc gaa gac aac ggc gat cac gta gtc atc caa gca ggc gaa 96Thr Ser Ile Glu Asp Asn Gly Asp His Val Val Ile Gln Ala Gly Glu<400>145cga aac agc caa ggc aaa tgg tgc cca agt acg cga tca cca aaa aat Arg Asn Ser Gln Gly Lys Trp Cys Pro Ser ThrArg Ser Pro Lys Asn 015

20 25 30gaa acc aca atc gtg gac cgc gtt atc gtc acc acc ggc agc tgg aca 144Glu Thr Thr Ile Val Asp Arg Val Ile Val Thr Thr Gly Ser Trp Thr

35 40 45agc gag ctc gtg ccc tcc atc gcg cca ctg ctt gaa gtg cga cgc cta 192Ser Glu Leu Val Pro Ser Ile Ala Pro Leu Leu Glu Val Arg Arg Leu

50 55 60gtg ctc acc tgg ttc ctg ccc aac aat cca gtg gac ttc caa ccg gaa 240Val Leu Thr Trp Phe Leu Pro Asn Asn Pro Val Asp Phe Gln Pro Glu 65 70 75 80aac ctg cca tgc ttc atc cgt gac cgt gat ggc ttc cac gta ttt gga 288Asn Leu Pro Cys Phe Ile Arg Asp Arg Asp Gly Phe His Val Phe Gly

85 90 95gca cca tgc gtc gat ggg tac agc atc aaa att gcc gga ttg gat gag 336Ala Pro Cys Val Asp Gly Tyr Ser Ile Lys Ile Ala Gly Leu Asp Glu

100 105 110tgg ggc gtt cca tta agc ctc gat cca ccg atg tgc cct cgg 378Trp Gly Val Pro Leu Ser Leu Asp Pro Pro Met Cys Pro Arg

115120125 tgatgtcctg atcccggttc cgg 401<210>146<211>126<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>146Arg Asn Ser Gln Gly Lys Trp Cys Pro Ser Thr Arg Ser Pro Lys Asn 151015 Thr Ser Ile Glu Asp Asn Gly Asp His Val Val Ile Gln Ala Gly Glu

20 25 30Glu Thr Thr Ile Val Asp Arg Val Ile Val Thr Thr Gly Ser Trp Thr

35 40 45Ser Glu Leu Val Pro Ser Ile Ala Pro Leu Leu Glu Val Arg Arg Leu

50 55 60Val Leu Thr TrpPhe Leu Pro Asn Asn Pro Val Asp Phe Gln Pro Glu 65 70 75 80Asn Leu Pro Cys Phe Ile Arg Asp Arg Asp Gly Phe His Val Phe Gly

85 90 95Ala Pro Cys Val Asp Gly Tyr Ser Ile Lys Ile Ala Gly Leu Asp Glu

100 105 110Trp Gly Val Pro Leu Ser Leu Asp Pro Pro Met Cys Pro Arg

115120125<210>147<211>488<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (478)<223>RXN02263<400>147cctgggcaac ccaagtgtat gaaaacgccc tggaaaaagg cgtcggcacc acattgaacc 60tgtgggaatc acccgcactg gcttgagaga agaaacaaca atg aaa att gcg gta 115

Met Lys Ile Ala Val

1 5atc ggc ctt gga tca acc ggc tcc atg gca ctg tgg cac tta agt aac 163Ile Gly Leu Gly Ser Thr Gly Ser Met Ala Leu Trp His Leu Ser Asn

10 15 20atc cca ggt gta gag gcc atc ggc ttt gaa caa ttc ggc atc tcc cat 211Ile Pro Gly Val Glu Ala Ile Gly Phe Glu Gln Phe Gly Ile Ser His

25 30 35ggc tac ggc gca ttc aca ggg gag tcc cga ctg ttt cgc atg gcc tac 259Gly Tyr Gly Ala Phe Thr Gly Glu Ser Arg Leu Phe Arg Met Ala Tyr

40 45 50cac gaa ggc agc acc tac gtt ccg ttg ctc aaa cgc gca cga gca cta 307His Glu Gly Ser Thr Tyr Val Pro Leu Leu Lys Arg Ala Arg Ala Leu

55 60 65tgg tca tca ctg agc gag att tcc gga cgc gaa ctc ttc cac aac ttc 355Trp Ser Ser Leu Ser Glu Ile Ser Gly Arg Glu Leu Phe His Asn Phe 70 75 80 85ggt gtc tta agc acc ggc aag gaa gac gaa gca ccc ttc caa cgc ctg 403Gly Val Leu Ser Thr Gly Lys Glu Asp Glu Ala Pro Phe Gln Arg Leu

90 95 100gtg gaa tca gtg gaa cgt tat gag ctg cca cat gaa cga ctt acc gcc 451Val Glu Ser Val Glu Arg Tyr Glu Leu Pro His Glu Arg Leu Thr Ala

105 110 115gcg cag atg cgc agc gtt acc cag gtc tagacttccg 488Ala Gln Met Arg Ser Val Thr Gln Val

120125<210>148<211>126<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>148Met Lys Ile Ala Val Ile Gly Leu Gly Ser Thr Gly Ser Met Ala Leu 151015 Trp His Leu Ser Asn Ile Pro Gly Val Glu Ala Ile Gly Phe Glu Gln

20 25 30Phe Gly Ile Ser His Gly Tyr Gly Ala Phe Thr Gly Glu Ser Arg Leu

35 40 45Phe Arg Met Ala Tyr His Glu Gly Ser Thr Tyr Val Pro Leu Leu Lys

50 55 60Arg Ala Arg Ala Leu Trp Ser Ser Leu Ser Glu Ile Ser Gly Arg Glu 65 70 75 80Leu Phe His Asn Phe Gly Val Leu Ser Thr Gly Lys Glu Asp Glu Ala

85 90 95Pro Phe Gln Arg Leu Val Glu Ser Val Glu Arg Tyr Glu Leu Pro His

100 105 110Glu Arg Leu Thr Ala Ala Gln Met Arg Ser Val Thr Gln Val

115120125<210>149<211>460<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (460)<223>FRXA02263<400>149cctgggcaac ccaagtgtat gaaaacgccc tggaaaaagg cgtcggcacc acattgaacc 60tgtgggaatc acccgcactg gcttgagaga agaaacaaca atg aaa att gcg gta 115

Met Lys Ile Ala Val

1 5atc ggc ctt gga tca acc ggc tcc atg gca ctg tgg cac tta agt aac 163Ile Gly Leu Gly Ser Thr Gly Ser Met Ala Leu Trp His Leu Ser Asn

10 15 20atc cca ggt gta gag gcc atc ggc ttt gaa caa ttc ggc atc tcc cat 211Ile Pro Gly Val Glu Ala Ile Gly Phe Glu Gln Phe Gly Ile Ser His

25 30 35ggc tac ggc gca ttc aca ggg gag tcc cga ctg ttt cgc atg gcc tac 259Gly Tyr Gly Ala Phe Thr Gly Glu Ser Arg Leu Phe Arg Met Ala Tyr

40 45 50cac gaa ggc agc acc tac gtt ccg ttg ctc aaa cgc gca cga gca cta 307His Glu Gly Ser Thr Tyr Val Pro Leu Leu Lys Arg Ala Arg Ala Leu

55 60 65tgg tca tca ctg agc gag att tcc gga cgc gaa ctc ttc cac aac ttc 355Trp Ser Ser Leu Ser Glu Ile Ser Gly Arg Glu Leu Phe His Asn Phe 70 75 80 85ggt gtc tta agc acc ggc aag gaa gac gaa gca ccc ttc caa cgc ctg 403Gly Val Leu Ser Thr Gly Lys Glu Asp Glu Ala Pro Phe Gln Arg Leu

90 95 100gtg gaa tca gtg gaa cgt tat gag ctg cca cat gaa cga ctt acc gcc 451Val Glu Ser Val Glu Arg Tyr Glu Leu Pro His Glu Arg Leu Thr Ala

105 110 115gcg cag atg 460Ala Gln Met

120<210>150<211>120<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>150Met Lys Ile Ala Val Ile Gly Leu Gly Ser Thr Gly Ser Met Ala Leu 151015 Trp His Leu Ser Asn Ile Pro Gly Val Glu Ala Ile Gly Phe Glu Gln

20 25 30Phe Gly Ile Ser His Gly Tyr Gly Ala Phe Thr Gly Glu Ser Arg Leu

35 40 45Phe Arg Met Ala Tyr His Glu Gly Ser Thr Tyr Val Pro Leu Leu Lys

50 55 60Arg Ala Arg Ala Leu Trp Ser Ser Leu Ser Glu Ile Ser Gly Arg Glu 65 70 75 80Leu Phe His Asn Phe Gly Val Leu Ser Thr Gly Lys Glu Asp Glu Ala

85 90 95Pro Phe Gln Arg Leu Val Glu Ser Val Glu Arg Tyr Glu Leu Pro His

100 105 110Glu Arg Leu Thr Ala Ala Gln Met

115120<210>151<211>1251<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1228)<223>RXA02176<400>151gggtgctagg aactgacagc ttcagggtta tagttgttgg gtcagatcgt taacgatccc 60tggccctttt acttccaagc gcagaaagtt gcccgaagac atg acc gac ttc ccc 115

Met Thr Asp Phe Pro

1 5acc ctg ccc tct gag ttc atc cct ggc gac ggc cgt ttc ggc tgc gga 163Thr Leu Pro Ser Glu Phe Ile Pro Gly Asp Gly Arg Phe Gly Cys Gly

10 15 20cct tcc aag gtt cga cca gaa cag att cag gct att gtc gac gga tcc 211Pro Ser Lys Val Arg Pro Glu Gln Ile Gln Ala Ile Val Asp Gly Ser

2530 35gca tcc gtc atc ggt acc tca cac cgt cag ccg gca gta aaa aac gtc 259Ala Ser Val Ile Gly Thr Ser His Arg Gln Pro Ala Val Lys Asn Val

40 45 50gtg ggt tca atc cgc gag gga ctc tcc gac ctc ttc tcc ctt cca gaa 307Val Gly Ser Ile Arg Glu Gly Leu Ser Asp Leu Phe Ser Leu Pro Glu

55 60 65ggc tac gag atc atc ctt tcc cta ggt ggt gcg acc gca ttc tgg gat 355Gly Tyr Glu Ile Ile Leu Ser Leu Gly Gly Ala Thr Ala Phe Trp Asp 70 75 80 85gca gca acc ttc gga ctc att gaa aag aag tcc ggt cac ctt tct ttc 403Ala Ala Thr Phe Gly Leu Ile Glu Lys Lys Ser Gly His Leu Ser Phe

90 95 100ggt gag ttc tcc tcc aag ttc gca aag gct tct aag ctt gct cct tgg 451Gly Glu Phe Ser Ser Lys Phe Ala Lys Ala Ser Lys Leu Ala Pro Trp

105 110 115ctc gac gag cca gag atc gtc acc gca gaa acc ggt gac tct ccg gcc 499Leu Asp Glu Pro Glu Ile Val Thr Ala Glu Thr Gly Asp Ser Pro Ala

120 125 130cca cag gca ttc gaa ggc gcc gat gtt att gca tgg gca cac aac gaa 547Pro Gln Ala Phe Glu Gly Ala Asp Val Ile Ala Trp Ala His Asn Glu

135 140 145acc tcc act ggc gcc atg gtt cca gtt ctt cgc ccc gaa ggc tct gaa 595Thr Ser Thr Gly Ala Met Val Pro Val Leu Arg Pro Glu Gly Ser Glu150 155 160 165ggc tcc ctg gtt gcc att gac gca acc tcc ggc gct ggt gga ctg cca 643Gly Ser Leu Val Ala Ile Asp Ala Thr Ser Gly Ala Gly Gly Leu Pro

170 175 180gta gac atc aag aac tcc gat gtt tac tac ttc tcc cca cag aag tgc 691Val Asp Ile Lys Asn Ser Asp Val Tyr Tyr Phe Ser Pro Gln Lys Cys

185 190 195ttc gca tcc gac ggt ggc ctg tgg ctt gca gcg atg agc cca gca gct 739Phe Ala Ser Asp Gly Gly Leu Trp Leu Ala Ala Met Ser Pro Ala Ala

200 205 210ctc gag cgc atc gag aag atc aac gct tcc gat cgc ttc atc cct gag 787Leu Glu Arg Ile Glu Lys Ile Asn Ala Ser Asp Arg Phe Ile Pro Glu

215 220 225ttc ctc aac ctg cag acc gca gtg gat aac tcc ctg aag aac cag acc 835Phe Leu Asn Leu Gln Thr Ala Val Asp Asn Ser Leu Lys Asn Gln Thr230 235 240 245tac aac acc cca gct gtt gct acc ttg ctg atg ctg gac aac cag gtc 883Tyr Asn Thr Pro Ala Val Ala Thr Leu Leu Met Leu Asp Asn Gln Val

250 255 260aag tgg atg aac tcc aac ggc ggc ctg gat gga atg gtt gct cgc acc 931Lys Trp Met Asn Ser Asn Gly Gly Leu Asp Gly Met Val Ala Arg Thr

265 270 275aca gca agc tcc tcc gcc ctg tac aac tgg gct gag gct cgc gag gag 979Thr Ala Ser Ser Ser Ala Leu Tyr Asn Trp Ala Glu Ala Arg Glu Glu

280 285 290gca tcc cca tac gtg gca gat gca gct aag cgc tcc ctc gtt gtc ggc 1027Ala Ser Pro Tyr Val Ala Asp Ala Ala Lys Arg Ser Leu Val Val Gly

295 300 305acc atc gac ttc gat gac tcc atc gac gca gca gtg atc gct aag ata 1075Thr Ile Asp Phe Asp Asp Ser Ile Asp Ala Ala Val Ile Ala Lys Ile310 315 320 325ctg cgc gca aac ggc atc ctg gac acc gag cct tac cgc aag ctg gga 1123Leu Arg Ala Asn Gly Ile Leu Asp Thr Glu Pro Tyr Arg Lys Leu Gly

330335 340cgc aac cag ctg cgc atc ggt atg ttc cca gcg atc gat tcc acc gat 1171Arg Asn Gln Leu Arg Ile Gly Met Phe Pro Ala Ile Asp Ser Thr Asp

345 350 355gtg gaa aag ctc acc gga gca atc gac ttc atc ctc gat ggc ggt ttt 1219Val Glu Lys Leu Thr Gly Ala Ile Asp Phe Ile Leu Asp Gly Gly Phe

360 365 370gca agg aag taataccccc actttgaaaa aca 1251Ala Arg Lys

375<210>152<211>376<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>152Met Thr Asp Phe Pro Thr Leu Pro Ser Glu Phe Ile Pro Gly Asp Gly 151015 Arg Phe Gly Cys Gly Pro Ser Lys Val Arg Pro Glu Gln Ile Gln Ala

20 25 30Ile Val Asp Gly Ser Ala Ser Val Ile Gly Thr Ser His Arg Gln Pro

35 40 45Ala Val Lys Asn Val Val Gly Ser Ile Arg Glu Gly Leu Ser Asp Leu

50 55 60Phe Ser Leu Pro Glu Gly Tyr Glu Ile Ile Leu Ser Leu Gly Gly Ala 65 70 75 80Thr Ala Phe Trp Asp Ala Ala Thr Phe Gly Leu Ile Glu Lys Lys Ser

85 90 95Gly His Leu Ser Phe Gly Glu Phe Ser Ser Lys Phe Ala Lys Ala Ser

100 105 110Lys Leu Ala Pro Trp Leu Asp Glu Pro Glu Ile Val Thr Ala Glu Thr

115 120 125Gly Asp Ser Pro Ala Pro Gln Ala Phe Glu Gly Ala Asp Val Ile Ala

130 135 140Trp Ala His Asn Glu Thr Ser Thr Gly Ala Met Val Pro Val Leu Arg145150 155 160Pro Glu Gly Ser Glu Gly Ser Leu Val Ala Ile Asp Ala Thr Ser Gly

165 170 175Ala Gly Gly Leu Pro Val Asp Ile Lys Asn Ser Asp Val Tyr Tyr Phe

180 185 190Ser Pro Gln Lys Cys Phe Ala Ser Asp Gly Gly Leu Trp Leu Ala Ala

195 200 205Met Ser Pro Ala Ala Leu Glu Arg Ile Glu Lys Ile Asn Ala Ser Asp

210 215 220Arg Phe Ile Pro Glu Phe Leu Asn Leu Gln Thr Ala Val Asp Asn Ser225 230 235 240Leu Lys Asn Gln Thr Tyr Asn Thr Pro Ala Val Ala Thr Leu Leu Met

245 250 255Leu Asp Asn Gln Val Lys Trp Met Asn Ser Asn Gly Gly Leu Asp Gly

260 265 270Met Val Ala Arg Thr Thr Ala Ser Ser Ser Ala Leu Tyr Asn Trp Ala

275 280 285Glu Ala Arg Glu Glu Ala Ser Pro Tyr Val Ala Asp Ala Ala Lys Arg

290 295 300Ser Leu Val Val Gly Thr Ile Asp Phe Asp Asp Ser Ile Asp Ala Ala305 310 315 320Val Ile Ala Lys Ile Leu Arg Ala Asn Gly Ile Leu Asp Thr Glu Pro

325 330 335Tyr Arg Lys Leu Gly Arg Asn Gln Leu Arg Ile Gly Met Phe Pro Ala

340 345 350Ile Asp Ser Thr Asp Val Glu Lys Leu Thr Gly Ala Ile Asp Phe Ile

355 360 365Leu Asp Gly Gly Phe Ala Arg Lys

370375<210>153<211>1422<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1399)<223>RXN02758<400>153atacatctca cccaattccc cataactaga caattgccca gcaacgactg ataagtctcc 60aatgtcgtgt tccgcgctca gacatgagac aattgttgcc gtg act gaa ctc atc 115

Val Thr Glu Leu Ile

1 5cag aat gaa tcc caa gaa atc gct gag ctg gaa gcc ggc cag cag gtt 163Gln Asn Glu Ser Gln Glu Ile Ala Glu Leu Glu Ala Gly Gln Gln Val

10 15 20gca ttg cgt gaa ggt tat ctt cct gcg gtg atc aca gtg agc ggt aaa 211Ala Leu Arg Glu Gly Tyr Leu Pro Ala Val Ile Thr Val Ser Gly Lys

25 30 35gac cgc cca ggt gtg act gcc gcg ttc ttt agg gtc ttg tcc gct aat 259Asp Arg Pro Gly Val Thr Ala Ala Phe Phe Arg Val Leu Ser Ala Asn

40 45 50cag gtt cag gtc ttg gac gtt gag cag tca atg ttc cgt ggc ttt ttg 307Gln Val Gln Val Leu Asp Val Glu Gln Ser Met Phe Arg Gly Phe Leu

55 60 65aac ttg gcg gcg ttt gtg ggt atc gca cct gag cgt gtc gag acc gtc 355Asn Leu Ala Ala Phe Val Gly Ile Ala Pro Glu Arg Val Glu Thr Val 70 75 80 85acc aca ggc ctg act gac acc ctc aag gtg cat gga cag tcc gtg gtg 403Thr Thr Gly Leu Thr Asp Thr Leu Lys Val His Gly Gln Ser Val Val

90 95 100gtg gag ctg cag gaa act gtg cag tcg tcc cgt cct cgt tct tcc cat 451Val Glu Leu Gln Glu Thr Val Gln Ser Ser Arg Pro Arg Ser Ser His

105 110 115gtt gtt gtggtg ttg ggt gat ccg gtt gat gcg ttg gat att tcc cgc 499Val Val Val Val Leu Gly Asp Pro Val Asp Ala Leu Asp Ile Ser Arg

120 125 130att ggt cag acc ctg gcg gat tac gat gcc aac att gac acc att cgt 547Ile Gly Gln Thr Leu Ala Asp Tyr Asp Ala Asn Ile Asp Thr Ile Arg

135 140 145ggt att tcg gat tac cct gtg acc ggc ctg gag ctg aag gtg act gtg 595Gly Ile Ser Asp Tyr Pro Val Thr Gly Leu Glu Leu Lys Val Thr Val150 155 160 165ccg gat gtc agc cct ggt ggt ggt gaa gcg atg cgt aag gcg ctt gct 643Pro Asp Val Ser Pro Gly Gly Gly Glu Ala Met Arg Lys Ala Leu Ala

170 175 180gct ctt acc tct gag ctg aat gtg gat att gcg att gag cgt tct ggt 691Ala Leu Thr Ser Glu Leu Asn Val Asp Ile Ala Ile Glu Arg Ser Gly

185 190 195ttg ctg cgt cgt tct aag cgt ctg gtg tgc ttc gat tgt gat tcc acg 739Leu Leu Arg Arg Ser Lys Arg Leu Val Cys Phe Asp Cys Asp Ser Thr

200 205 210ttg atc act ggt gag gtc att gag atg ctg gcg gct cac gcg ggc aag 787Leu Ile Thr Gly Glu Val Ile Glu Met Leu Ala Ala His Ala Gly Lys

215 220 225gaa gct gaa gtt gcg gca gtt act gag cgt gcg atg cgc ggt gag ctc 835Glu Ala Glu Val Ala Ala Val Thr Glu Arg Ala Met Arg Gly Glu Leu230 235 240 245gat ttc gag gag tct ctg cgt gag cgt gtg aag gcg ttg gct ggt ttg 883Asp Phe Glu Glu Ser Leu Arg Glu Arg Val Lys Ala Leu Ala Gly Leu

250 255 260gat gcg tcg gtg atc gat gag gtc gct gcc gct att gag ctg acc cct 931Asp Ala Ser Val Ile Asp Glu Val Ala Ala Ala Ile Glu Leu ThrPro

265 270 275ggt gcg cgc acc acg atc cgt acg ctg aac cgc atg ggt tac cag acc 979Gly Ala Arg Thr Thr Ile Arg Thr Leu Asn Arg Met Gly Tyr Gln Thr

280 285 290gct gtt gtt tcc ggt ggt ttc atc cag gtg ttg gaa ggt ttg gct gag 1027Ala Val Val Ser Gly Gly Phe Ile Gln Val Leu Glu Gly Leu Ala Glu

295 300 305gag ttg gag ttg gat tat gtc cgc gcc aac act ttg gaa atc gtt gat 1075Glu Leu Glu Leu Asp Tyr Val Arg Ala Asn Thr Leu Glu Ile Val Asp310 315 320 325ggc aag ctg acc ggc aac gtc acc gga aag atc gtt gac cgc gct gcg 1123Gly Lys Leu Thr Gly Asn Val Thr Gly Lys Ile Val Asp Arg Ala Ala

330 335 340aag gct gag ttc ctc cgt gag ttc gct gcg gat tct ggc ctg aag atg 1171Lys Ala Glu Phe Leu Arg Glu Phe Ala Ala Asp Ser Gly Leu Lys Met

345 350 355tac cag act gtc gct gtc ggt gat ggc gct aat gac atc gat atg ctc 1219Tyr Gln Thr Val Ala Val Gly Asp Gly Ala Asn Asp Ile Asp Met Leu

360 365 370tcc gct gcg ggt ctg ggt gtt gct ttc aac gcg aag cct gcg ctg aag 1267Ser Ala Ala Gly Leu Gly Val Ala Phe Asn Ala Lys Pro Ala Leu Lys

375 380 385gag att gcg gat act tcc gtg aac cac cca ttc ctc gac gag gtt ttg 1315Glu Ile Ala Asp Thr Ser Val Asn His Pro Phe Leu Asp Glu Val Leu390 395 400 405cac atc atg ggc att tcc cgc gac gag atc gat ctg gcg gat cag gaa 1363His Ile Met Gly Ile Ser Arg Asp Glu Ile Asp Leu Ala Asp Gln Glu

410 415 420gac ggc act ttc cac cgc gtt cca ttg acc aat gcc taaagattcg 1409Asp Gly Thr Phe His Arg Val Pro Leu Thr Asn Ala

425430 tttctcgacg ccc 1422<2>154<211>433<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>154Val Thr Glu Leu Ile Gln Asn Glu Ser Gln Glu Ile Ala Glu Leu Glu 151015 Ala Gly Gln Gln Val Ala Leu Arg Glu Gly Tyr Leu Pro Ala Val Ile

20 25 30Thr Val Ser Gly Lys Asp Arg Pro Gly Val Thr Ala Ala Phe Phe Arg

35 40 45Val Leu Ser Ala Asn Gln Val Gln Val Leu Asp Val Glu Gln Ser Met

50 55 60Phe Arg Gly Phe Leu Asn Leu Ala Ala Phe Val Gly Ile Ala Pro Glu 65 70 75 80Arg Val Glu Thr Val Thr Thr Gly Leu Thr Asp Thr Leu Lys Val His

85 90 95Gly Gln Ser Val Val Val Glu Leu Gln Glu Thr Val Gln Ser Ser Arg

100 105 110Pro Arg Ser Ser His Val Val Val Val Leu Gly Asp Pro Val Asp Ala

115 120 125Leu Asp Ile Ser Arg Ile Gly Gln Thr Leu Ala Asp Tyr Asp Ala Asn

130 135 140Ile Asp Thr Ile Arg Gly Ile Ser Asp Tyr Pro Val Thr Gly Leu Glu145 150 155 160Leu Lys Val Thr Val Pro Asp Val Ser Pro Gly Gly Gly Glu Ala Met

165 170 175Arg Lys Ala Leu Ala Ala Leu Thr Ser Glu Leu Asn Val Asp Ile Ala

180 185 190Ile Glu Arg Ser Gly Leu Leu Arg Arg Ser Lys Arg Leu Val Cys Phe

195 200 205Asp Cys Asp Ser Thr Leu Ile Thr Gly Glu Val Ile Glu Met Leu Ala

210 215 220Ala His Ala Gly Lys Glu Ala Glu Val Ala Ala Val Thr Glu Arg Ala225 230 235 240Met Arg Gly Glu Leu Asp Phe Glu Glu Ser Leu Arg Glu Arg Val Lys

245 250 255Ala Leu Ala Gly Leu Asp Ala Ser Val Ile Asp Glu Val Ala Ala Ala

260 265 270Ile Glu Leu Thr Pro Gly Ala Arg Thr Thr Ile Arg Thr Leu Asn Arg

275 280 285Met Gly Tyr Gln Thr Ala Val Val Ser Gly Gly Phe Ile Gln Val Leu

290 295 300Glu Gly Leu Ala Glu Glu Leu Glu Leu Asp Tyr Val Arg Ala Asn Thr305 3l0 315 320Leu Glu Ile Val Asp Gly Lys Leu Thr Gly Asn Val Thr Gly Lys Ile

325 330 335Val Asp Arg Ala Ala Lys Ala Glu Phe Leu Arg Glu Phe Ala Ala Asp

340 345 350Ser Gly Leu Lys Met Tyr Gln Thr Val Ala Val Gly Asp Gly Ala Asn

355 360 365Asp Ile Asp Met Leu Ser Ala Ala Gly Leu Gly Val Ala Phe Asn Ala

370 375 380Lys Pro Ala Leu Lys Glu Ile Ala Asp Thr Ser Val Asn His Pro Phe385 390 395 400Leu Asp Glu Val Leu His Ile Met Gly Ile Ser Arg Asp Glu Ile Asp

405 410 415Leu Ala Asp Gln Glu Asp Gly Thr Phe His Arg Val Pro Leu Thr Asn

420425430 Ala<210>155<211>490<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (490)<223>FRXA02479<400>155atacatctca cccaattccc cataactaga caattgccca gcaacgactg ataagtctcc 60aatgtcgtgt tccgcgctca gacatgagac aattgttgcc gtg act gaa ctc atc 115

Val Thr Glu Leu Ile

1 5cag aat gaa tcc caa gaa atc gct gag ctg gaa gcc ggc cag cag gtt 163Gln Asn Glu Ser Gln Glu Ile Ala Glu Leu Glu Ala Gly Gln Gln Val

10 15 20gca ttg cgt gaa ggt tat ctt cct gcg gtg atc aca gtg agc ggt aaa 211Ala Leu Arg Glu Gly Tyr Leu Pro Ala Val Ile Thr Val Ser Gly Lys

25 30 35gac cgc cca ggt gtg act gcc gcg ttc ttt agg gtc ttg tcc gct aat 259Asp Arg Pro Gly Val Thr Ala Ala Phe Phe Arg Val Leu Ser Ala Asn

40 45 50cag gtt cag gtc ttg gac gtt gag cag tca atg ttc cgt ggc ttt ttg 307Gln Val Gln Val Leu Asp Val Glu Gln Ser Met Phe Arg Gly Phe Leu

55 60 65aac ttg gcg gcg ttt gtg ggt atc gca cct gag cgt gtc gag acc gtc 355Asn Leu Ala Ala Phe Val Gly Ile Ala Pro Glu Arg Val Glu Thr Val 70 75 80 85acc aca ggc ctg act gac acc ctc aag gtg cat gga cag tcc gtg gtg 403Thr Thr Gly Leu Thr Asp Thr Leu Lys Val His Gly Gln Ser Val Val

90 95 l00gtg gag ctg cag gaa act gtg cag tcg tcc cgt cct cgt tct tcc cat 451Val Glu Leu Gln Glu Thr Val Gln Ser Ser Arg Pro Arg Ser Ser His

105110 115gtt gtt gtg gtg ttg ggt gat ccg gtt gat gcg ctg gat 490Val Val Val Val Leu Gly Asp Pro Val Asp Ala Leu Asp

120125130<210>156<211>130<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>156Val Thr Glu Leu Ile Gln Asn Glu Ser Gln Glu Ile Ala Glu Leu Glu 151015 Ala Gly Gln Gln Val Ala Leu Arg Glu Gly Tyr Leu Pro Ala Val Ile

20 25 30Thr Val Ser Gly Lys Asp Arg Pro Gly Val Thr Ala Ala Phe Phe Arg

35 40 45Val Leu Ser Ala Asn Gln Val Gln Val Leu Asp Val Glu Gln Ser Met

50 55 60Phe Arg Gly Phe Leu Asn Leu Ala Ala Phe Val Gly Ile Ala Pro Glu 65 70 75 80Arg Val Glu Thr Val Thr Thr Gly Leu Thr Asp Thr Leu Lys Val His

85 90 95Gly Gln Ser Val Val Val Glu Leu Gln Glu Thr Val Gln Ser Ser Arg

100 105 110Pro Arg Ser Ser His Val Val Val Val Leu Gly Asp Pro Val Asp Ala

115 120 125Leu Asp

130<210>157<211>558<212>DNA<213>Corynebacterium glutamicum (corenebacterium glutamicum)<220><221>CDS<222>(101). (535)<223>FRXA02758<400>157aaggcgttgg ctggtttgga tgcgtcggtg atcgatgagg tcgctgccgc tattgagctg 60acccttggtg cgcgcaccac gatccgtacg gttgaaccgc atg ggt tac cag acc 115

Met Gly Tyr Gln Thr

1 5gct gttgtt tcc ggt ggt ttc atc cag gtg ttg gaa ggt ttg gct gag 163Ala Val Val Ser Gly Gly Phe Ile Gln Val Leu Glu Gly Leu Ala Glu

10 15 20gag ttg gag ttg gat tat gtc cgc gcc aac act ttg gaa atc gtt gat 211Glu Leu Glu Leu Asp Tyr Val Arg Ala Asn Thr Leu Glu Ile Val Asp

25 30 35ggc aag ctg acc ggc aac gtc acc gga aag atc gtt gac cgc gct gcg 259Gly Lys Leu Thr Gly Asn Val Thr Gly Lys Ile Val Asp Arg Ala Ala

40 45 50aag gct gag ttc ctc cgt gag ttc gct gcg gat tct ggc ctg aag atg 307Lys Ala Glu Phe Leu Arg Glu Phe Ala Ala Asp Ser Gly Leu Lys Met

55 60 65tac cag act gtc gct gtc ggt gat ggc gct aat gac atc gat atg ctc 355Tyr Gln Thr Val Ala Val Gly Asp Gly Ala Asn Asp Ile Asp Met Leu 70 75 80 85tcc gct gcg ggt ctg ggt gtt gct ttc aac gcg aag cct gcg ctg aag 403Ser Ala Ala Gly Leu Gly Val Ala Phe Asn Ala Lys Pro Ala Leu Lys

90 95 100gag att gcg gat act tcc gtg aac cac cca ttc ctc gac gag gtt ttg 451Glu Ile Ala Asp Thr Ser Val Asn His Pro Phe Leu Asp Glu Val Leu

105 110 115cac atc atg ggc att tcc cgc gac gag atc gat ctg gcg gat cag gaa 499His Ile Met Gly Ile Ser Arg Asp Glu Ile Asp Leu Ala Asp Gln Glu

120 125 130gac ggc act ttc cac cgc gtt cca ttg acc aat gcc taaagattcg 545Asp Gly Thr Phe His Arg Val Pro Leu Thr Asn Ala

135140145 tttctcgacg ccc 558<210>158<211>145<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>158Met Gly Tyr Gln Thr Ala Val Val Ser Gly Gly Phe Ile Gln Val Leu 151015 Glu Gly Leu Ala Glu Glu Leu Glu Leu Asp Tyr Val Arg Ala Asn Thr

20 25 30Leu Glu Ile Val Asp Gly Lys Leu Thr Gly Asn Val Thr Gly Lys Ile

35 40 45Val Asp Arg Ala Ala Lys Ala Glu Phe Leu Arg Glu Phe Ala Ala Asp

50 55 60Ser Gly Leu Lys Met Tyr Gln Thr Val Ala Val Gly Asp Gly Ala Asn 65 70 75 80Asp Ile Asp Met Leu Ser Ala Ala Gly Leu Gly Val Ala Phe Asn Ala

85 90 95Lys Pro Ala Leu Lys Glu Ile Ala Asp Thr Ser Val Asn His Pro Phe

100 105 110Leu Asp Glu Val Leu His Ile Met Gly Ile Ser Arg Asp Glu Ile Asp

115 120 125Leu Ala Asp Gln Glu Asp Gly Thr Phe His Arg Val Pro Leu Thr Asn

130135140 Ala145<210>159<211>205<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(72) } (182)<223>FRXA02759<400>159tcttacttct aagctgaatg tgatattgcg attaagcgtt ctggtttgct gcgtcgttct 60aagcgtctgg t gtg ctt cga ttg tat ccc acg ttg atc act ggt gag gtc 110

Val Leu Arg Leu Tyr Pro Thr Leu Ile Thr Gly Glu Val

1 5 10att gag atg ctg gcg gct cac gcg ggc aag gaa gct aaa gtt gcg gca 158Ile Glu Met Leu Ala Ala His Ala Gly Lys Glu Ala Lys Val Ala Ala

152025 gtt act gag cgt gcg atg cgc ggg tgagctcgat ttcgaggagt ctc 205Val Thr Glu Arg Ala Met Arg Gly 3035<210>160<211>37<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>160Val Leu Arg Leu Tyr Pro Thr Leu Ile Thr Gly Glu Val Ile Glu Met 151015 Leu Ala Ala His Ala Gly Lys Glu Ala Lys Val Ala Ala Val Thr Glu

20 25 30Arg Ala Met Arg Gly

35<210>161<211>1188<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1165)<223>RXA02501<400>161cgccccgaaa gctttaccat ggatacgata ctcaatggag atatccatta tcggtttggc 60gtctgtgcgc tcatgaacca ggaaggtttt tgtttgtctc atg agc tct gaa gga 115

Met Ser Ser Glu Gly

1 5aga aac cac aac tgg gac tac gcc gcc atc ggc acc cca gag gat ttc 163Arg Asn His Asn Trp Asp Tyr Ala Ala Ile Gly Thr Pro Glu Asp Phe

10 15 20ctc gcc agc tgg agc gca tcc cgc gga aat cta cga cgc ttt ttc gaa 211Leu Ala Ser Trp Ser Ala Ser Arg Gly Asn Leu Arg Arg Phe Phe Glu

25 30 35gac cac gca gcc gcc ccc ata aac gat gcc gcc cag cgc caa gca ggt 259Asp His Ala Ala Ala Pro Ile Asn Asp Ala Ala Gln Arg Gln Ala Gly

40 45 50gaa gcc gca gca acc caa gcc gtc gca gcg atc tac ggc atg gag ctc 307Glu Ala Ala Ala Thr Gln Ala Val Ala Ala Ile Tyr Gly Met Glu Leu

55 60 65aac gaa ttc aac gca ggt gtc gac gcc gtc gcc ggc gcc atc gaa tct 355Asn Glu Phe Asn Ala Gly Val Asp Ala Val Ala Gly Ala Ile Glu Ser 70 75 80 85gcc ggc gcc atc cac gtc agc atc ccc gat ccc gat gtc ccc caa gat 403Ala Gly Ala Ile His Val Ser Ile Pro Asp Pro Asp Val Pro Gln Asp

90 95 100gtc gga gcc gca gca ttt ttc gac gtc gac aac acc ctc atc caa ggc 451Val Gly Ala Ala Ala Phe Phe Asp Val Asp Asn Thr Leu Ile Gln Gly

105 110 115tcc tcc ctc atc gtt ttc gcc caa gga ctc ttc cgg aag aaa ttc ttc 499Ser Ser Leu Ile Val Phe Ala Gln Gly Leu Phe Arg Lys Lys Phe Phe

120 125 130acc atc aaa gaa atc ctc ccc gtg gtg tgg aaa caa gtg aaa ttc aaa 547Thr Ile Lys Glu Ile Leu Pro Val Val Trp Lys Gln Val Lys Phe Lys

135 140 145ctc acc ggc tcc gaa aac gcc gac gac gtc tcc cgc ggc cgc gaa caa 595Leu Thr Gly Ser Glu Asn Ala Asp Asp Val Ser Arg Gly Arg Glu Gln150 155 160 165gcc ctc gaa ttc atc aaa ggc cgc ccc gtc caa gaa cta gtt gac ctc 643Ala Leu Glu Phe Ile Lys Gly Arg Pro Val Gln Glu Leu Val Asp Leu

170 175 180tgc gaa gaa atc gtc gac caa cgc atg gcc gac aaa atg tgg ccc ggc 691Cys Glu Glu Ile Val Asp Gln Arg Met Ala Asp Lys Met Trp Pro Gly

185 190 195acc aaa caa ctc gcc gac atg cac atc gcc gcc ggc cac caa gtc tgg 739Thr Lys Gln Leu Ala Asp Met His Ile Ala Ala Gly His Gln Val Trp

200 205 210ctc gtc tcc gca acc ccc gtc caa ctc gcc caa atc ctg gca caa cgc 787Leu Val Ser Ala Thr Pro Val Gln Leu Ala Gln Ile Leu Ala Gln Arg

215 220 225ctc ggc ttc acc gga gcg atc ggc aca gtc gca gaa gca aaa gat gga 835Leu Gly Phe Thr Gly Ala Ile Gly Thr Val Ala Glu Ala Lys Asp Gly230 235240 245gta ttc acc ggc cga ctc gtc ggc gac atc ctc cac gga ccc ggc aaa 883Val Phe Thr Gly Arg Leu Val Gly Asp Ile Leu His Gly Pro Gly Lys

250 255 260aga cac gca gtc gca gca ctc gca tcc atc gaa caa ctc gac ctc acc 931Arg His Ala Val Ala Ala Leu Ala Ser Ile Glu Gln Leu Asp Leu Thr

265 270 275cga tgc acc gcc tac tcc gac tcc atc aac gac ctc ccc atg ctc tcc 979Arg Cys Thr Ala Tyr Ser Asp Ser Ile Asn Asp Leu Pro Met Leu Ser

280 285 290atg gtc ggc acc gcc gtc gca gta aac ccc gac tcc aaa ctc cgc aaa 1027Met Val Gly Thr Ala Val Ala Val Asn Pro Asp Ser Lys Leu Arg Lys

295 300 305gaa gcc gaa acc cga ggc tgg gac gtc cgc gat ttc cga agc atc cgc 1075Glu Ala Glu Thr Arg Gly Trp Asp Val Arg Asp Phe Arg Ser Ile Arg310 315 320 325aaa gcc acc cgc gaa tac gga atc ccc gcc ctg gtc acc gcc gca ttc 1123Lys Ala Thr Arg Glu Tyr Gly Ile Pro Ala Leu Val Thr Ala Ala Phe

330 335 340agt gtc gcc ggc tgg agt cta cgc cgc cga tgg aga aaa caa 1165Ser Val Ala Gly Trp Ser Leu Arg Arg Arg Trp Arg Lys Gln

345350355 taacgcacag gagccgtttt aag 1188<210>162<211>355<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>162Met Ser Ser Glu Gly Arg Asn His Asn Trp Asp Tyr Ala Ala Ile Gly 151015 Thr Pro Glu Asp Phe Leu Ala Ser Trp Ser Ala Ser Arg Gly Asn Leu

20 25 30Arg Arg Phe Phe Glu Asp His Ala Ala Ala Pro Ile Asn Asp Ala Ala

35 40 45Gln Arg Gln Ala Gly Glu Ala Ala Ala Thr Gln Ala Val Ala Ala Ile

50 55 60Tyr Gly Met Glu Leu Asn Glu Phe Asn Ala Gly Val Asp Ala Val Ala 65 70 75 80Gly Ala Ile Glu Ser Ala Gly Ala Ile His Val Ser Ile Pro Asp Pro

85 90 95Asp Val Pro Gln Asp Val Gly Ala Ala Ala Phe Phe Asp Val Asp Asn

100 105 110Thr Leu Ile Gln Gly Ser Ser Leu Ile Val Phe Ala Gln Gly Leu Phe

115 120 125Arg Lys Lys Phe Phe Thr Ile Lys Glu Ile Leu Pro Val Val Trp Lys

130 135 140Gln Val Lys Phe Lys Leu Thr Gly Ser Glu Asn Ala Asp Asp Val Ser145 150 155 160Arg Gly Arg Glu Gln Ala Leu Glu Phe Ile Lys Gly Arg Pro Val Gln

165 170 175Glu Leu Val Asp Leu Cys Glu Glu Ile Val Asp Gln Arg Met Ala Asp

180 185 190Lys Met Trp Pro Gly Thr Lys Gln Leu Ala Asp Met His Ile Ala Ala

195 200 205Gly His Gln Val Trp Leu Val Ser Ala Thr Pro Val Gln Leu Ala Gln

210 215 220Ile Leu Ala Gln Arg Leu Gly Phe Thr Gly Ala Ile Gly Thr Val Ala225 230 235 240Glu Ala Lys Asp Gly Val Phe Thr Gly Arg Leu Val Gly Asp Ile Leu

245 250 255His Gly Pro Gly Lys Arg His Ala Val Ala Ala Leu Ala Ser Ile Glu

260 265 270Gln Leu Asp Leu Thr Arg Cys Thr Ala Tyr Ser Asp Ser Ile Asn Asp

275 280 285Leu Pro Met Leu Ser Met Val Gly Thr Ala Val Ala Val Asn Pro Asp

290 295 300Ser Lys Leu Arg Lys Glu Ala Glu Thr Arg Gly Trp Asp Val Arg Asp305 310 315 320Phe Arg Ser Ile Arg Lys Ala Thr Arg Glu Tyr Gly Ile Pro Ala Leu

325 330 335Val Thr Ala Ala Phe Ser Val Ala Gly Trp Ser Leu Arg Arg Arg Trp

340 345 350Arg Lys Gln

355<210>163<211>558<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (535)<223>RXN03105<400>163ggttggggtc atcaaaggat gcggacatcg ctgtggggtt gtgtaataat tgcacctgtg 60aggtgccttt ctggcaggtg aatcaggact ctaagcaagc ttg att ctt cca gtt 115

Leu Ile Leu Pro Val

1 5cag gag ggc att tcc tat ttt ccc acg ccg tta cac ctg aat cac atc 163Gln Glu Gly Ile Ser Tyr Phe Pro Thr Pro Leu His Leu Asn His Ile

10 15 20ggt gga tcc agg tta agc gca cat gta gaa gat gaa gat ctc cgc ctc 211Gly Gly Ser Arg Leu Ser Ala His Val Glu Asp Glu Asp Leu Arg Leu

25 30 35gac cgg gac gca gtc tct gaa ttt ggt cgg aaa acc cac gaa ctc ttc 259Asp Arg Asp Ala Val Ser Glu Phe Gly Arg Lys Thr His Glu Leu Phe

40 45 50ccc ggg gtc aac cca gag ccc aac cgt ttc agc gtc cac tat gac acc 307Pro Gly Val Asn Pro Glu Pro Asn Arg Phe Ser Val His Tyr Asp Thr

55 60 65tac act gca gac aaa tct cca att atc gac gcg gtt gac aat gtc att 355Tyr Thr Ala Asp Lys Ser Pro Ile Ile Asp Ala Val Asp Asn Val Ile 70 75 80 85gtg ctc acc gga gga tcc gga cac gcc ttc aag ctc tct cca gct tat 403Val Leu Thr Gly Gly Ser Gly His Ala Phe Lys Leu Ser Pro Ala Tyr

90 95 100ggc gaa ctc gca gca caa cga gcg gtc gga aac acc tcg ccg ctg tac 451Gly Glu Leu Ala Ala Gln Arg Ala Val Gly Asn Thr Ser Pro Leu Tyr

105 110 115agc gaa gac ttt cgg atc gcc tcg cat gaa cca atc aaa gag cgg tgc 499Ser Glu Asp Phe Arg Ile Ala Ser His Glu Pro Ile Lys Glu Arg Cys

120 125 130acg tat aga aag cta acc ttt tta agt gcg cgg ttt tagggtgaga 545Thr Tyr Arg Lys Leu Thr Phe Leu Ser Ala Arg Phe

135140145 atctaacgct gag 558<210>164<211>145<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>164Leu Ile Leu Pro Val Gln Glu Gly Ile Ser Tyr Phe Pro Thr Pro Leu 151015 His Leu Asn His Ile Gly Gly Ser Arg Leu Ser Ala His Val Glu Asp

20 25 30Glu Asp Leu Arg Leu Asp Arg Asp Ala Val Ser Glu Phe Gly Arg Lys

35 40 45Thr His Glu Leu Phe Pro Gly Val Asn Pro Glu Pro Asn Arg Phe Ser

50 55 60Val His Tyr Asp Thr Tyr Thr Ala Asp Lys Ser Pro Ile Ile Asp Ala 65 70 75 80Val Asp Asn Val Ile Val Leu Thr Gly Gly Ser Gly His Ala Phe Lys

8590 95Leu Ser Pro Ala Tyr Gly Glu Leu Ala Ala Gln Arg Ala Val Gly Asn

100 105 110Thr Ser Pro Leu Tyr Ser Glu Asp Phe Arg Ile Ala Ser His Glu Pro

115 120 125Ile Lys Glu Arg Cys Thr Tyr Arg Lys Leu Thr Phe Leu Ser Ala Arg

130135140 Phe145<210>165<211>687<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(62) } (664)<223>RXS01130<400>165agttcgtggc ggatgctgtg aacgtttccg gtggtcgcgt gggcgaagag gttctgtgtg 60g atg gat ctg gct cgc aag ctt ggt ctt ctt gct ggc aag ctt gtc gac 109 Met Asp Leu Ala Arg Lys Leu Gly Leu Leu Ala Gly Lys Leu Val Asp

1 5 10 15gcc gcc cca gtc tcc att gag gtt gag gct cga ggc gag ctt tct tcc 157Ala Ala Pro Val Ser Ile Glu Val Glu Ala Arg Gly Glu Leu Ser Ser

20 25 30gag cag gtc aat gca ctt ggt ttg tcc gct gtt cgt ggt ttg ttc tcc 205Glu Gln Val Asn Ala Leu Gly Leu Ser Ala Val Arg Gly Leu Phe Ser

35 40 45gga att atc gaa gag tcc gtt act ttc gtc aac gct cct cgc att gct 253Gly Ile Ile Glu Glu Ser Val Thr Phe Val Asn Ala Pro Arg Ile Ala

50 55 60gaa gag cgt ggc ctg gac atc tcc gtg aag acc aac tct gag tct gtt 301Glu Glu Arg Gly Leu Asp Ile Ser Val Lys Thr Asn Ser Glu Ser Val 65 70 75 80act cac cgt tcc gtc ctg cag gtc aag gtc att act ggc agc ggc gcg 349Thr His Arg Ser Val Leu Gln Val Lys Val Ile Thr Gly Ser Gly Ala

85 90 95agc gca act gtt gtt ggtgcc ctg act ggt ctt gag cgc gtt gag aag 397Ser Ala Thr Val Val Gly Ala Leu Thr Gly Leu Glu Arg Val Glu Lys

100 105 110atc acc cgc atc aat ggc cgt ggc ctg gat ctg cgc gca gag ggt ctg 445Ile Thr Arg Ile Asn Gly Arg Gly Leu Asp Leu Arg Ala Glu Gly Leu

115 120 125aac ctc ttc ctg cag tac act gac gct cct ggt gca ctg ggt acc gtt 493Asn Leu Phe Leu Gln Tyr Thr Asp Ala Pro Gly Ala Leu Gly Thr Val

130 135 140ggt acc aag ctg ggt gct gct ggc atc aac atc gag gct gct gcg ttg 541Gly Thr Lys Leu Gly Ala Ala Gly Ile Asn Ile Glu Ala Ala Ala Leu145 150 155 160act cag gct gag aag ggt gac ggc gct gtc ctg atc ctg cgt gtt gag 589Thr Gln Ala Glu Lys Gly Asp Gly Ala Val Leu Ile Leu Arg Val Glu

165 170 175tcc gct gtc tct gaa gag ctg gaa gct gaa atc aac gct gag ttg ggt 637Ser Ala Val Ser Glu Glu Leu Glu Ala Glu Ile Asn Ala Glu Leu Gly

180 185 190gct act tcc ttc cag gtt gat ctt gac taattagaga tccatttgct 684Ala Thr Ser Phe Gln Val Asp Leu Asp

195200 tga 687<210>166<211>201<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>166Met Asp Leu Ala Arg Lys Leu Gly Leu Leu Ala Gly Lys Leu Val Asp 151015 Ala Ala Pro Val Ser Ile Glu Val Glu Ala Arg Gly Glu Leu Ser Ser

20 25 30Glu Gln Val Asn Ala Leu Gly Leu Ser Ala Val Arg Gly Leu Phe Ser

35 40 45Gly Ile Ile Glu Glu Ser Val Thr Phe Val Asn Ala Pro Arg Ile Ala

5055 60Glu Glu Arg Gly Leu Asp Ile Ser Val Lys Thr Asn Ser Glu Ser Val65 70 75 80Thr His Arg Ser Val Leu Gln Val Lys Val Ile Thr Gly Ser Gly Ala

85 90 95Ser Ala Thr Val Val Gly Ala Leu Thr Gly Leu Glu Arg Val Glu Lys

100 105 110Ile Thr Arg Ile Asn Gly Arg Gly Leu Asp Leu Arg Ala Glu Gly Leu

115 120 125Asn Leu Phe Leu Gln Tyr Thr Asp Ala Pro Gly Ala Leu Gly Thr Val

130 135 140Gly Thr Lys Leu Gly Ala Ala Gly Ile Asn Ile Glu Ala Ala Ala Leu145 150 155 160Thr Gln Ala Glu Lys Gly Asp Gly Ala Val Leu Ile Leu Arg Val Glu

165 170 175Ser Ala Val Ser Glu Glu Leu Glu Ala Glu Ile Asn Ala Glu Leu Gly

180 185 190Ala Thr Ser Phe Gln Val Asp Leu Asp

195200<210>167<211>604<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (604)<223>RXS03112<400>167gtgagcacgc aatttctttg ctgctgtcta ctgctcgcca gatcctgctg ctgatgcgac 60gctgcgtgag ggcgagtgga agcggtcttc tttcaacggt gtg gaa att ttc gga 115

Val Glu Ile Phe Gly

1 5aaa act gtc ggt atc gtc ggt ttt ggc cac att ggt cag ttg ttt gct 163Lys Thr Val Gly Ile Val Gly Phe Gly His Ile Gly Gln Leu Phe Ala

10 1520cag cgt ctt gct gcg ttt gag acc acc att gtt gct tac gat cct tac 211Gln Arg Leu Ala Ala Phe Glu Thr Thr Ile Val Ala Tyr Asp Pro Tyr

25 30 35gct aac cct gct cgt gcg gct cag ctg aac gtt gag ttg gtt gag ttg 259Ala Asn Pro Ala Arg Ala Ala Gln Leu Asn Val Glu Leu Val Glu Leu

40 45 50gat gag ctg atg agc cgt tct gac ttt gtc acc att cac ctt cct aag 307Asp Glu Leu Met Ser Arg Ser Asp Phe Val Thr Ile His Leu Pro Lys

55 60 65acc aag gaa act gct ggc atg ttt gat gcg cac ctc ctt gct aag tcc 355Thr Lys Glu Thr Ala Gly Met Phe Asp Ala His Leu Leu Ala Lys Ser 70 75 80 85aag aag ggc cag atc atc atc aac gct gct cgt ggt ggc ctt gtt gat 403Lys Lys Gly Gln Ile Ile Ile Asn Ala Ala Arg Gly Gly Leu Val Asp

90 95 100gag cag gct ttg gct gat gcg att gag tcc ggt cac att cgt ggc gct 451Glu Gln Ala Leu Ala Asp Ala Ile Glu Ser Gly His Ile Arg Gly Ala

105 110 115ggt ttc gat gtg tac tcc acc gag cct tgc act gat tct cct ttg ttc 499Gly Phe Asp Val Tyr Ser Thr Glu Pro Cys Thr Asp Ser Pro Leu Phe

120 125 130aag ttg cct cag gtt gtt gtg act cct cac ttg ggt gct tct act gaa 547Lys Leu Pro Gln Val Val Val Thr Pro His Leu Gly Ala Ser Thr Glu

135140145 gag gct caa gat cgt gcg ggt act gac att gct gat tct gtg ctc aag 595Glu Ala Gln Asp Arg Ala Gly Thr Asp Ile Ala Asp Ser Val Leu Lys 150155160165 gcg ctg gct 604Ala Leu Ala<210>168<211>168<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>168Val Glu Ile Phe Gly Lys Thr Val Gly Ile Val Gly Phe Gly His Ile 151015 Gly Gln Leu Phe Ala Gln Arg Leu Ala Ala Phe Glu Thr Thr Ile Val

20 25 30Ala Tyr Asp Pro Tyr Ala Asn Pro Ala Arg Ala Ala Gln Leu Asn Val

35 40 45Glu Leu Val Glu Leu Asp Glu Leu Met Ser Arg Ser Asp Phe Val Thr

50 55 60Ile His Leu Pro Lys Thr Lys Glu Thr Ala Gly Met Phe Asp Ala His 65 70 75 80Leu Leu Ala Lys Ser Lys Lys Gly Gln Ile Ile Ile Asn Ala Ala Arg

85 90 95Gly Gly Leu Val Asp Glu Gln Ala Leu Ala Asp Ala Ile Glu Ser Gly

100 105 110His Ile Arg Gly Ala Gly Phe Asp Val Tyr Ser Thr Glu Pro Cys Thr

115 120 125Asp Ser Pro Leu Phe Lys Leu Pro Gln Val Val Val Thr Pro His Leu

130 135 140Gly Ala Ser Thr Glu Glu Ala Gln Asp Arg Ala Gly Thr Asp Ile Ala145 150 155 160Asp Ser Val Leu Lys Ala Leu Ala

165<210>169<211>1458<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1435)<223>RXN00969<400>169ctatagtggc taggtaccct ttttgttttg gacacatgta gggtggccga aacaaagtaa 60taggacaaca acgctcgacc gcgattattt ttggagaatc atg acc tca gca tct 115

Met Thr Ser Ala Ser

1 5gcc cca agc ttt aac ccc ggc aag ggt ccc ggc tca gca gtc gga att 163Ala Pro Ser Phe Asn Pro Gly Lys Gly Pro Gly Ser Ala Val Gly Ile

10 15 20gcc ctt tta gga ttc gga aca gtc ggc act gag gtg atg cgt ctg atg 211Ala Leu Leu Gly Phe Gly Thr Val Gly Thr Glu Val Met Arg Leu Met

25 30 35acc gag tac ggt gat gaa ctt gcg cac cgc att ggt ggc cca ctg gag 259Thr Glu Tyr Gly Asp Glu Leu Ala His Arg Ile Gly Gly Pro Leu Glu

40 45 50gtt cgt ggc att gct gtt tct gat atc tca aag cca cgt gaa ggc gtt 307Val Arg Gly Ile Ala Val Ser Asp Ile Ser Lys Pro Arg Glu Gly Val

55 60 65gca cct gag ctg ctc act gag gac gct ttt gca ctc atc gag cgc gag 355Ala Pro Glu Leu Leu Thr Glu Asp Ala Phe Ala Leu Ile Glu Arg Glu 70 75 80 85gat gtt gac atc gtc gtt gag gtt atc ggc ggc att gag tac cca cgt 403Asp Val Asp Ile Val Val Glu Val Ile Gly Gly Ile Glu Tyr Pro Arg

90 95 100gag gta gtt ctc gca gct ctg aag gcc ggc aag tct gtt gtt acc gcc 451Glu Val Val Leu Ala Ala Leu Lys Ala Gly Lys Ser Val Val Thr Ala

105 110 115aat aag gct ctt gtt gca gct cac tct gct gag ctt gct gat gca gcg 499Asn Lys Ala Leu Val Ala Ala His Ser Ala Glu Leu Ala Asp Ala Ala

120 125 130gaa gcc gca aac gtt gac ctg tac ttc gag gct gct gtt gca tgc gca 547Glu Ala Ala Asn Val Asp Leu Tyr Phe Glu Ala Ala Val Ala Cys Ala 135 140 145att cca gtg gtt ggc cca ctg cgt cgc tcc ctg gct ggc gat cag atc 595Ile Pro Val Val Gly Pro Leu Arg Arg Ser Leu Ala Gly Asp Gln Ile150 155 160 165cag tct gtg atg ggc atc gtt aac ggcacc acc aac ttc atc ttg gac 643Gln Ser Val Met Gly Ile Val Asn Gly Thr Thr Asn Phe Ile Leu Asp

170 175 180gcc atg gat tcc acc ggc gct gac tat gca gat tct ttg gct gag gca 691Ala Met Asp Ser Thr Gly Ala Asp Tyr Ala Asp Ser Leu Ala Glu Ala

185 190 195act cgt ttg ggt tac gcc gaa gct gat cca act gca aac gtc gaa ggc 739Thr Arg Leu Gly Tyr Ala Glu Ala Asp Pro Thr Ala Asn Val Glu Gly

200 205 210cat gac gcc gca tcc aag gct gca att ttg gca tgc atc gct ttc cac 787His Asp Ala Ala Ser Lys Ala Ala Ile Leu Ala Cys Ile Ala Phe His

215 220 225acc cgt gtt acc gcg gat gat gtg tac tgc gaa ggt att agg aac atc 835Thr Arg Val Thr Ala Asp Asp Val Tyr Cys Glu Gly Ile Arg Asn Ile230 235 240 245aac gct gcc gac att gag gca gca cag cag gca ggc cac acc atc aag 883Asn Ala Ala Asp Ile Glu Ala Ala Gln Gln Ala Gly His Thr Ile Lys

250 255 260ttg ttg gcc atc tgt gag aag ttc acc aac aag gaa gga aag tcg gct 931Leu Leu Ala Ile Cys Glu Lys Phe Thr Asn Lys Glu Gly Lys Ser Ala

265 270 275att tct gct cgc gtg cac ccg act cta tta cct gtg tcc cac cca ctg 979Ile Ser Ala Arg Val His Pro Thr Leu Leu Pro Val Ser His Pro Leu

280 285 290gcg tcg gta aac aag tcc ttt aat gca atc ttt gtt gaa gca gaa gca 1027Ala Ser Val Asn Lys Ser Phe Asn Ala Ile Phe Val Glu Ala Glu Ala

295 300 305gct ggt cgc ctg atg ttc tac gga aac ggt gca ggt ggc gcg cca acc 1075Ala Gly Arg Leu Met Phe Tyr Gly Asn Gly Ala GlyGly Ala Pro Thr310 315 320 325gcg tct gct gtg ctt ggc gac gtc gtt ggt gcc gca cga aac aag gtg 1123Ala Ser Ala Val Leu Gly Asp Val Val Gly Ala Ala Arg Asn Lys Val

330 335 340cac ggt ggc cgt gct cca ggt gag tcc acc tac gct aac ctg ccg atc 1171His Gly Gly Arg Ala Pro Gly Glu Ser Thr Tyr Ala Asn Leu Pro Ile

345 350 355gct gat ttc ggt gag acc acc act cgt tac cac ctc gac atg gat gtg 1219Ala Asp Phe Gly Glu Thr Thr Thr Arg Tyr His Leu Asp Met Asp Val

360 365 370gaa gat cgc gtg ggg gtt ttg gct gaa ttg gct agc ctg ttc tct gag 1267Glu Asp Arg Val Gly Val Leu Ala Glu Leu Ala Ser Leu Phe Ser Glu

375 380 385caa gga atc tcc ctg cgt aca atc cga cag gaa gag cgc gat gat gat 1315Gln Gly Ile Ser Leu Arg Thr Ile Arg Gln Glu Glu Arg Asp Asp Asp390 395 400 405gca cgt ctg atc gtg gtc acc cac tct gcg ctg gaa tct gat ctt tcc 1363Ala Arg Leu Ile Val Val Thr His Ser Ala Leu Glu Ser Asp Leu Ser

410 415 420cgc acc gtt gaa ctg ctg aag gct aag cct gtt gtt aag gca atc aac 1411Arg Thr Val Glu Leu Leu Lys Ala Lys Pro Val Val Lys Ala Ile Asn

425 430 435agt gtg atc cgc ctc gaa agg gac taattttact gacatggcaa ttg 1458Ser Val Ile Arg Leu Glu Arg Asp

440445<210>170<211>445<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>170Met Thr Ser Ala Ser Ala Pro Ser Phe Asn Pro Gly Lys Gly Pro Gly 151015 Ser Ala Val Gly Ile Ala Leu Leu Gly Phe Gly Thr Val Gly Thr Glu

20 25 30Val Met Arg Leu Met Thr Glu Tyr Gly Asp Glu Leu Ala His Arg Ile

35 40 45Gly Gly Pro Leu Glu Val Arg Gly Ile Ala Val Ser Asp Ile Ser Lys

50 55 60Pro Arg Glu Gly Val Ala Pro Glu Leu Leu Thr Glu Asp Ala Phe Ala 65 70 75 80Leu Ile Glu Arg Glu Asp Val Asp Ile Val Val Glu Val Ile Gly Gly

85 90 95Ile Glu Tyr Pro Arg Glu Val Val Leu Ala Ala Leu Lys Ala Gly Lys

100 105 110Ser Val Val Thr Ala Asn Lys Ala Leu Val Ala Ala His Ser Ala Glu

115 120 125Leu Ala Asp Ala Ala Glu Ala Ala Asn Val Asp Leu Tyr Phe Glu Ala

130 135 140Ala Val Ala Cys Ala Ile Pro Val Val Gly Pro Leu Arg Arg Ser Leu145 150 155 160Ala Gly Asp Gln Ile Gln Ser Val Met Gly Ile Val Asn Gly Thr Thr

165 170 175Asn Phe Ile Leu Asp Ala Met Asp Ser Thr Gly Ala Asp Tyr Ala Asp

180 185 190Ser Leu Ala Glu Ala Thr Arg Leu Gly Tyr Ala Glu Ala Asp Pro Thr

195 200 205Ala Asn Val Glu Gly His Asp Ala Ala Ser Lys Ala Ala Ile Leu Ala

210 215 220Cys Ile Ala Phe His Thr Arg Val Thr Ala Asp Asp Val Tyr Cys Glu225 230 235 240Gly Ile Arg Asn Ile Asn Ala Ala Asp Ile Glu Ala Ala Gln Gln Ala

245250 255Gly His Thr Ile Lys Leu Leu Ala Ile Cys Glu Lys Phe Thr Asn Lys

260 265 270Glu Gly Lys Ser Ala Ile Ser Ala Arg Val His Pro Thr Leu Leu Pro

275 280 285Val Ser His Pro Leu Ala Ser Val Asn Lys Ser Phe Asn Ala Ile Phe

290 295 300Val Glu Ala Glu Ala Ala Gly Arg Leu Met Phe Tyr Gly Asn Gly Ala305 310 315 320Gly Gly Ala Pro Thr Ala Ser Ala Val Leu Gly Asp Val Val Gly Ala

325 330 335Ala Arg Asn Lys Val His Gly Gly Arg Ala Pro Gly Glu Ser Thr Tyr

340 345 350Ala Asn Leu Pro Ile Ala Asp Phe Gly Glu Thr Thr Thr Arg Tyr His

355 360 365Leu Asp Met Asp Val Glu Asp Arg Val Gly Val Leu Ala Glu Leu Ala

370 375 380Ser Leu Phe Ser Glu Gln Gly Ile Ser Leu Arg Thr Ile Arg Gln Glu385 390 395 400Glu Arg Asp Asp Asp Ala Arg Leu Ile Val Val Thr His Ser Ala Leu

405 410 415Glu Ser Asp Leu Ser Arg Thr Val Glu Leu Leu Lys Ala Lys Pro Val

420 425 430Val Lys Ala Ile Asn Ser Val Ile Arg Leu Glu Arg Asp

435440445<210>171<211>493<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (493)<223>FRXA00974<400>171ctatagtggc taggtaccct ttttgttttg gacacatgta gggtggccga aacaaagtaa 60taggacaaca acgctcgacc gcgattatttttggagaatc atg acc tca gca tct 115

Met Thr Ser Ala Ser

1 5gcc cca agc ttt aac ccc ggc aag ggt ccc ggc tca gca gtc gga att 163Ala Pro Ser Phe Asn Pro Gly Lys Gly Pro Gly Ser Ala Val Gly Ile

10 15 20gcc ctt tta gga ttc gga aca gtc ggc act gag gtg atg cgt ctg atg 211Ala Leu Leu Gly Phe Gly Thr Val Gly Thr Glu Val Met Arg Leu Met

25 30 35acc gag tac ggt gat gaa ctt gcg cac cgc att ggt ggc cca ctg gag 259Thr Glu Tyr Gly Asp Glu Leu Ala His Arg Ile Gly Gly Pro Leu Glu

40 45 50gtt cgt ggc att gct gtt tct gat atc tca aag cca cgt gaa ggc gtt 307Val Arg Gly Ile Ala Val Ser Asp Ile Ser Lys Pro Arg Glu Gly Val

55 60 65gca cct gag ctg ctc act gag gac gct ttt gca ctc atc gag cgc gag 355Ala Pro Glu Leu Leu Thr Glu Asp Ala Phe Ala Leu Ile Glu Arg Glu 70 75 80 85gat gtt gac atc gtc gtt gag gtt atc ggc ggc att gag tac cca cgt 403Asp Val Asp Ile Val Val Glu Val Ile Gly Gly Ile Glu Tyr Pro Arg

90 95 100gag gta gtt ctc gca gct ctg aag gcc ggc aag tct gtt gtt acc gcc 451Glu Val Val Leu Ala Ala Leu Lys Ala Gly Lys Ser Val Val Thr Ala

105 110 115aat aag gct ctt gtt gca gct cac tct gct gag ctt gct gat 493Asn Lys Ala Leu Val Ala Ala His Ser Ala Glu Leu Ala Asp

120125130<210>172<211>131<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>172Met Thr Ser Ala Ser Ala Pro Ser Phe Asn Pro Gly Lys Gly Pro Gly 151015 Ser Ala Val Gly Ile Ala Leu Leu Gly Phe Gly Thr Val Gly Thr Glu

20 25 30Val Met Arg Leu Met Thr Glu Tyr Gly Asp Glu Leu Ala His Arg Ile

35 40 45Gly Gly Pro Leu Glu Val Arg Gly Ile Ala Val Ser Asp Ile Ser Lys

50 55 60Pro Arg Glu Gly Val Ala Pro Glu Leu Leu Thr Glu Asp Ala Phe Ala 65 70 75 80Leu Ile Glu Arg Glu Asp Val Asp Ile Val Val Glu Val Ile Gly Gly

85 90 95Ile Glu Tyr Pro Arg Glu Val Val Leu Ala Ala Leu Lys Ala Gly Lys

100 105 110Ser Val Val Thr Ala Asn Lys Ala Leu Val Ala Ala His Ser Ala Glu

115 120 125Leu Ala Asp

130<210>173<211>1050<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1027)<223>RXA00970<400>173gaatctgatc tttcccgcac cgttgaactg ctgaaggcta agcctgttgt taaggcaatc 60aacagtgtga tccgcctcga aagggactaa ttttactgac atg gca att gaa ctg 115

Met Ala Ile Glu Leu

1 5aac gtc ggt cgt aag gtt acc gtc acg gta cct gga tct tct gca aac 163Asn Val Gly Arg Lys Val Thr Val Thr Val Pro Gly Ser Ser Ala Asn

10 15 20ctc gga cct ggc ttt gac act tta ggt ttg gca ctg tcg gta tac gac 211Leu Gly Pro Gly Phe Asp Thr Leu Gly Leu Ala Leu Ser Val Tyr Asp

25 30 35act gtc gaa gtg gaa att att cca tct ggc ttg gaa gtg gaa gtt ttt 259Thr Val Glu Val Glu Ile Ile Pro Ser Gly Leu Glu Val Glu Val Phe

40 45 50ggc gaa ggc caa ggc gaa gtc cct ctt gat ggc tcc cac ctg gtg gtt 307Gly Glu Gly Gln Gly Glu Val Pro Leu Asp Gly Ser His Leu Val Val

55 60 65aaa gct att cgt gct ggc ctg aag gca gct gac gct gaa gtt cct gga 355Lys Ala Ile Arg Ala Gly Leu Lys Ala Ala Asp Ala Glu Val Pro Gly 70 75 80 85ttg cga gtg gtg tgc cac aac aac att ccg cag tct cgt ggt ctt ggc 403Leu Arg Val Val Cys His Asn Asn Ile Pro Gln Ser Arg Gly Leu Gly

90 95 100tcc tct gct gca gcg gcg gtt gct ggt gtt gct gca gct aat ggt ttg 451Ser Ser Ala Ala Ala Ala Val Ala Gly Val Ala Ala Ala Asn Gly Leu

105 110 115gcg gat ttc ccg ctg act caa gag cag att gtt cag ttg tcc tct gcc 499Ala Asp Phe Pro Leu Thr Gln Glu Gln Ile Val Gln Leu Ser Ser Ala

120 125 130ttt gaa ggc cac cca gat aat gct gcg gct tct gtg ctg ggt gga gca 547Phe Glu Gly His Pro Asp Asn Ala Ala Ala Ser Val Leu Gly Gly Ala

135 140 145gtg gtg tcg tgg aca aat ctg tct atc gac ggc aag agc cag cca cag 595Val Val Ser Trp Thr Asn Leu Ser Ile Asp Gly Lys Ser Gln Pro Gln150 155 160 165tat gct gct gta cca ctt gag gtg cag gac aat att cgt gcg act gcg 643Tyr Ala Ala Val Pro Leu Glu Val Gln Asp Asn Ile Arg Ala Thr Ala

170 175 180ctg gtt cct aat ttc cac gca tcc acc gaa gct gtg cgc cga gtc ctt 691Leu Val Pro Asn Phe His Ala Ser Thr Glu Ala Val Arg Arg Val Leu

185 190 195ccc act gaa gtc act cac atc gat gcg cga ttt aac gtg tcc cgc gtt 739Pro Thr Glu Val Thr His Ile Asp Ala Arg Phe Asn Val Ser Arg Val

200 205 210gca gtg atg atc gtt gcg ttg cag cag cgt cct gat ttg ctg tgg gag 787Ala Val Met Ile Val Ala Leu Gln Gln Arg Pro Asp Leu Leu Trp Glu

215 220 225ggt act cgt gac cgt ctg cac cag cct tat cgt gca gaa gtg ttg cct 835Gly Thr Arg Asp Arg Leu His Gln Pro Tyr Arg Ala Glu Val Leu Pro230 235 240 245att acc tct gag tgg gta aac cgc ctg cgc aac cgt ggc tac gcg gca 883Ile Thr Ser Glu Trp Val Asn Arg Leu Arg Asn Arg Gly Tyr Ala Ala

250 255 260tac ctt tcc ggt gcc ggc cca acc gcc atg gtg ctg tcc act gag cca 931Tyr Leu Ser Gly Ala Gly Pro Thr Ala Met Val Leu Ser Thr Glu Pro

265 270 275att cca gac aag gtt ttg gaa gat gct cgt gag tct ggc att aag gtg 979Ile Pro Asp Lys Val Leu Glu Asp Ala Arg Glu Ser Gly Ile Lys Val

280 285 290ctt gag ctt gag gtt gcg gga cca gtc aag gtt gaa gtt aac caa cct 1027Leu Glu Leu Glu Val Ala Gly Pro Val Lys Val Glu Val Asn Gln Pro

295300305 taggcccaac aaggaaggcc ccc 1050<210>174<21l>309<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>174Met Ala Ile Glu Leu Asn Val Gly Arg Lys Val Thr Val Thr Val Pro 151015 Gly Ser Ser Ala Asn Leu Gly Pro Gly Phe Asp Thr Leu Gly Leu Ala

20 25 30Leu Ser Val Tyr Asp Thr Val Glu Val Glu Ile Ile Pro Ser Gly Leu

35 40 45Glu Val Glu Val Phe Gly Glu Gly Gln Gly Glu Val Pro Leu Asp Gly

50 55 60Ser His Leu Val Val Lys Ala Ile Arg Ala Gly Leu Lys Ala Ala Asp 65 70 75 80Ala Glu Val Pro Gly Leu Arg Val Val Cys His Asn Asn Ile Pro Gln

85 90 95Ser Arg Gly Leu Gly Ser Ser Ala Ala Ala Ala Val Ala Gly Val Ala

100 105 110Ala Ala Asn Gly Leu Ala Asp Phe Pro Leu Thr Gln Glu Gln Ile Val

115 120 125Gln Leu Ser Ser Ala Phe Glu Gly His Pro Asp Asn Ala Ala Ala Ser

130 135 140Val Leu Gly Gly Ala Val Val Ser Trp Thr Asn Leu Ser Ile Asp Gly145 150 155 160Lys Ser Gln Pro Gln Tyr Ala Ala Val Pro Leu Glu Val Gln Asp Asn

165 170 175Ile Arg Ala Thr Ala Leu Val Pro Asn Phe His Ala Ser Thr Glu Ala

180 185 190Val Arg Arg Val Leu Pro Thr Glu Val Thr His Ile Asp Ala Arg Phe

195 200 205Asn Val Ser Arg Val Ala Val Met Ile Val Ala Leu Gln Gln Arg Pro

210 215 220Asp Leu Leu Trp Glu Gly Thr Arg Asp Arg Leu His Gln Pro Tyr Arg225 230 235 240Ala Glu Val Leu Pro Ile Thr Ser Glu Trp Val Asn Arg Leu Arg Asn

245 250 255Arg Gly Tyr Ala Ala Tyr Leu Ser Gly Ala Gly Pro Thr Ala Met Val

260 265 270Leu Ser Thr Glu Pro Ile Pro Asp Lys Val Leu Glu Asp Ala Arg Glu

275 280 285Ser Gly Ile Lys Val Leu Glu Leu Glu Val Ala Gly Pro Val Lys Val

290295300 Glu Val Asn Gln Pro305<210>175<211>1566<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1543)<223>RXA00330<400>175gcaacacttt agggtatcgc gtgggcgaag tcaccttttt caacatattt gagacggtgt 60gggggagtat tgtgtcaccc cttgggatag ggttatatcc gtg gac tac att tcg 115

Val Asp Tyr Ile Ser

1 5acg cgt gat gcc agc cgt acc cct gcc cgc ttc agt gat att ttg ctg 163Thr Arg Asp Ala Ser Arg Thr Pro Ala Arg Phe Ser Asp Ile Leu Leu

10 15 20ggc ggt cta gca cca gac ggc gga ctg tac ctg cct gca acc tac cct 211Gly Gly Leu Ala Pro Asp Gly Gly Leu Tyr Leu Pro Ala Thr Tyr Pro

25 30 35caa cta gat gat gcc cag ctg agt aaa tgg cgt gag gta tta gcc aac 259Gln Leu Asp Asp Ala Gln Leu Ser Lys Trp Arg Glu Val Leu Ala Asn

40 45 50gaa gga tac gca gct ttg gct gct gaa gtt atc tcc ctg ttt gtt gat 307Glu Gly Tyr Ala Ala Leu Ala Ala Glu Val Ile Ser Leu Phe Val Asp

55 60 65gac atc cca gta gaa gac atc aag gcg atc acc gca cgc gcc tac acc 355Asp Ile Pro Val Glu Asp Ile Lys Ala Ile Thr Ala Arg Ala Tyr Thr 70 75 80 85tac ccg aag ttc aac agcgaa gac atc gtt cct gtc acc gaa ctc gag 403Tyr Pro Lys Phe Asn Ser Glu Asp Ile Val Pro Val Thr Glu Leu Glu

90 95 100gac aac att tac ctg ggc cac ctt tcc gaa ggc cca acc gct gca ttc 451Asp Asn Ile Tyr Leu Gly His Leu Ser Glu Gly Pro Thr Ala Ala Phe

105 110 115aaa gac atg gcc atg cag ctg ctc ggc gaa ctt ttc gaa tac gag ctt 499Lys Asp Met Ala Met Gln Leu Leu Gly Glu Leu Phe Glu Tyr Glu Leu

120 125 130cgc cgc cgc aac gaa acc atc aac atc ctg ggc gct acc tct ggc gat 547Arg Arg Arg Asn Glu Thr Ile Asn Ile Leu Gly Ala Thr Ser Gly Asp

135 140 145acc ggc tcc tct gcg gaa tac gcc atg cgc ggc cgc gag gga atc cgc 595Thr Gly Ser Ser Ala Glu Tyr Ala Met Arg Gly Arg Glu Gly Ile Arg150 155 160 165gta ttc atg ctg acc cca gct ggc cgc atg acc cca ttc cag caa gca 643Val Phe Met Leu Thr Pro Ala Gly Arg Met Thr Pro Phe Gln Gln Ala

170 175 180cag atg ttt ggc ctt gac gat cca aac atc ttc aac atc gcc ctc gac 691Gln Met Phe Gly Leu Asp Asp Pro Asn Ile Phe Asn Ile Ala Leu Asp

185 190 195ggc gtt ttc gac gat tgc caa gac gta gtc aag gct gtc tcc gcc gac 739Gly Val Phe Asp Asp Cys Gln Asp Val Val Lys Ala Val Ser Ala Asp

200 205 210gca gaa ttc aaa aaa gac aac cgc atc ggt gcc gtg aac tcc atc aac 787Ala Glu Phe Lys Lys Asp Asn Arg Ile Gly Ala Val Asn Ser Ile Asn

215 220 225tgg gca cgc ctt atg gca cag gtt gtg tac tac gtt tcc tca tgg atc 835Trp Ala Arg Leu Met Ala Gln Val Val Tyr Tyr Val Ser Ser Trp Ile230 235 240 245cgc acc aca acc agc aat gac caa aag gtc agc ttc tcc gta cca acc 883Arg Thr Thr Thr Ser Asn Asp Gln Lys Val Ser Phe Ser Val Pro Thr

250 255 260ggc aac ttc ggt gac att tgc gca ggc cac atc gcc cgc caa atg gga 931Gly Asn Phe Gly Asp Ile Cys Ala Gly His Ile Ala Arg Gln Met Gly

265 270 275ctt ccc atc gat cgc ctc atc gtg gcc acc aac gaa aac gat gtg ctc 979Leu Pro Ile Asp Arg Leu Ile Val Ala Thr Asn Glu Asn Asp Val Leu

280 285 290gac gag ttc ttc cgt acc ggc gac tac cga gtc cgc agc tcc gca gac 1027Asp Glu Phe Phe Arg Thr Gly Asp Tyr Arg Val Arg Ser Ser Ala Asp

295 300 305acc cac gag acc tcc tca cct tcg atg gat atc tcc cgc gcc tcc aac 1075Thr His Glu Thr Ser Ser Pro Ser Met Asp Ile Ser Arg Ala Ser Asn310 315 320 325ttc gag cgt ttc atc ttc gac ctg ctc ggc cgc gac gcc acc cgc gtc 1123Phe Glu Arg Phe Ile Phe Asp Leu Leu Gly Arg Asp Ala Thr Arg Val

330 335 340aac gat cta ttt ggt acc cag gtt cgc caa ggc gga ttc tca ctg gct 1171Asn Asp Leu Phe Gly Thr Gln Val Arg Gln Gly Gly Phe Ser Leu Ala

345 350 355gat gac gcc aac ttt gag aag gct gca gca gaa tac ggt ttc gcc tcc 1219Asp Asp Ala Asn Phe Glu Lys Ala Ala Ala Glu Tyr Gly Phe Ala Ser

360 365 370gga cga tcc acc cat gct gac cgt gtg gca acc atc gct gac gtg cat 1267Gly Arg Ser Thr His Ala Asp Arg Val Ala Thr Ile Ala Asp Val His

375 380385tcc cgc ctc gac gta cta atc gat ccc cac acc gcc gac ggc gtt cac 1315Ser Arg Leu Asp Val Leu Ile Asp Pro His Thr Ala Asp Gly Val His390 395 400 405gtg gca cgc cag tgg agg gac gag gtc aac acc cca atc atc gtc cta 1363Val Ala Arg Gln Trp Arg Asp Glu Val Asn Thr Pro Ile Ile Val Leu

410 415 420gaa act gca ctc cca gtg aaa ttt gcc gac acc atc gtc gaa gca att 1411Glu Thr Ala Leu Pro Val Lys Phe Ala Asp Thr Ile Val Glu Ala Ile

425 430 435ggt gaa gca cct caa act cca gag cgt ttc gcc gcg atc atg gat gct 1459Gly Glu Ala Pro Gln Thr Pro Glu Arg Phe Ala Ala Ile Met Asp Ala

440 445 450cca ttc aag gtt tcc gac cta cca aac gac acc gat gca gtt aag cag 1507Pro Phe Lys Val Ser Asp Leu Pro Asn Asp Thr Asp Ala Val Lys Gln

455460465 tac ata gtc gat gcg att gca aac act tcc gtg aag taacttgctt 1553Tyr Ile Val Asp Ala Ile Ala Asn Thr Ser Val Lys 470475480 tacgccaagg cct 1566<210>176<211>481<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>176Val Asp Tyr Ile Ser Thr Arg Asp Ala Ser Arg Thr Pro Ala Arg Phe 151015 Ser Asp Ile Leu Leu Gly Gly Leu Ala Pro Asp Gly Gly Leu Tyr Leu

20 25 30Pro Ala Thr Tyr Pro Gln Leu Asp Asp Ala Gln Leu Ser Lys Trp Arg

35 40 45Glu Val Leu Ala Asn Glu Gly Tyr Ala Ala Leu Ala Ala Glu Val Ile

50 55 60Ser Leu Phe Val Asp Asp Ile Pro Val Glu Asp Ile Lys Ala Ile Thr 65 70 75 80Ala Arg Ala Tyr Thr Tyr Pro Lys Phe Asn Ser Glu Asp Ile Val Pro

85 90 95Val Thr Glu Leu Glu Asp Asn Ile Tyr Leu Gly His Leu Ser Glu Gly

100 105 110Pro Thr Ala Ala Phe Lys Asp Met Ala Met Gln Leu Leu Gly Glu Leu

115 120 125Phe Glu Tyr Glu Leu Arg Arg Arg Asn Glu Thr Ile Asn Ile Leu Gly

130 135 140Ala Thr Ser Gly Asp Thr Gly Ser Ser Ala Glu Tyr Ala Met Arg Gly145 150 155 160Arg Glu Gly Ile Arg Val Phe Met Leu Thr Pro Ala Gly Arg Met Thr

165 170 175Pro Phe Gln Gln Ala Gln Met Phe Gly Leu Asp Asp Pro Asn Ile Phe

180 185 190Asn Ile Ala Leu Asp Gly Val Phe Asp Asp Cys Gln Asp Val Val Lys

195 200 205Ala Val Ser Ala Asp Ala Glu Phe Lys Lys Asp Asn Arg Ile Gly Ala

210 215 220Val Asn Ser Ile Asn Trp Ala Arg Leu Met Ala Gln Val Val Tyr Tyr225 230 235 240Val Ser Ser Trp Ile Arg Thr Thr Thr Ser Asn Asp Gln Lys Val Ser

245 250 255Phe Ser Val Pro Thr Gly Asn Phe Gly Asp Ile Cys Ala Gly His Ile

260 265 270Ala Arg Gln Met Gly Leu Pro Ile Asp Arg Leu Ile Val Ala Thr Asn

275 280 285Glu Asn Asp Val Leu Asp Glu Phe Phe Arg Thr Gly Asp Tyr Arg Val

290 295 300Arg Ser Ser Ala Asp Thr His Glu Thr Ser Ser Pro Ser Met Asp Ile305 310 315 320Ser Arg Ala Ser Asn Phe Glu Arg Phe Ile Phe Asp Leu Leu Gly Arg

325 330 335Asp Ala Thr Arg Val Asn Asp Leu Phe Gly Thr Gln Val Arg Gln Gly

340 345 350Gly Phe Ser Leu Ala Asp Asp Ala Asn Phe Glu Lys Ala Ala Ala Glu

355 360 365Tyr Gly Phe Ala Ser Gly Arg Ser Thr His Ala Asp Arg Val Ala Thr

370 375 380Ile Ala Asp Val His Ser Arg Leu Asp Val Leu Ile Asp Pro His Thr385 390 395 400Ala Asp Gly Val His Val Ala Arg Gln Trp Arg Asp Glu Val Asn Thr

405 410 415Pro Ile Ile Val Leu Glu Thr Ala Leu Pro Val Lys Phe Ala Asp Thr

420 425 430Ile Val Glu Ala Ile Gly Glu Ala Pro Gln Thr Pro Glu Arg Phe Ala

435 440 445Ala Ile Met Asp Ala Pro Phe Lys Val Ser Asp Leu Pro Asn Asp Thr

450455460 Asp Ala Val Lys Gln Tyr Ile Val Asp Ala Ile Ala Asn Thr Ser Val 465470475480 Lys<210>177<21l>1254<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1231)<223>RXN00403<400>177tttttcagac tcgtgagaat gcaaactaga ctagacagag ctgtccatat acactggacg 60aagttttagt cttgtccacc cagaacaggc ggttattttc atg ccc acc ctc gcg 115

Met Pro Thr Leu Ala

1 5cct tca ggt caa ctt gaa atc caa gcg atc ggt gat gtc tcc acc gaa 163Pro SerGly Gln Leu Glu Ile Gln Ala Ile Gly Asp Val Ser Thr Glu

10 15 20gcc gga gca atc att aca aac gct gaa atc gcc tat cac cgc tgg ggt 211Ala Gly Ala Ile Ile Thr Asn Ala Glu Ile Ala Tyr His Arg Trp Gly

25 30 35gaa tac cgc gta gat aaa gaa gga cgc agc aat gtc gtt ctc atc gaa 259Glu Tyr Arg Val Asp Lys Glu Gly Arg Ser Asn Val Val Leu Ile Glu

40 45 50cac gcc ctc act gga gat tcc aac gca gcc gat tgg tgg gct gac ttg 307His Ala Leu Thr Gly Asp Ser Asn Ala Ala Asp Trp Trp Ala Asp Leu

55 60 65ctc ggt ccc ggc aaa gcc atc aac act gat att tac tgc gtg atc tgt 355Leu Gly Pro Gly Lys Ala Ile Asn Thr Asp Ile Tyr Cys Val Ile Cys 70 75 80 85acc aac gtc atc ggt ggt tgc aac ggt tcc acc gga cct ggc tcc atg 403Thr Asn Val Ile Gly Gly Cys Asn Gly Ser Thr Gly Pro Gly Ser Met

90 95 100cat cca gat gga aat ttc tgg ggt aat cgc ttc ccc gcc acg tcc att 451His Pro Asp Gly Asn Phe Trp Gly Asn Arg Phe Pro Ala Thr Ser Ile

105 110 115cgt gat cag gta aac gcc gaa aaa caa ttc ctc gac gca ctc ggc atc 499Arg Asp Gln Val Asn Ala Glu Lys Gln Phe Leu Asp Ala Leu Gly Ile

120 125 130acc acg gtc gcc gca gta ctt ggt ggt tcc atg ggt ggt gcc cgc acc 547Thr Thr Val Ala Ala Val Leu Gly Gly Ser Met Gly Gly Ala Arg Thr

135 140 145cta gag tgg gcc gca atg tac cca gaa act gtt ggc gca gct gct gtt 595Leu Glu Trp Ala Ala Met Tyr Pro Glu Thr Val Gly Ala Ala Ala Val150 155160 165ctt gca gtt tct gca cgc gcc agc gcc tgg caa atc ggc att caa tcc 643Leu Ala Val Ser Ala Arg Ala Ser Ala Trp Gln Ile Gly Ile Gln Ser

170 175 180gcc caa att aag gcg att gaa aac gac cac cac tgg cac gaa ggc aac 691Ala Gln Ile Lys Ala Ile Glu Asn Asp His His Trp His Glu Gly Asn

185 190 195tac tac gaa tcc ggc tgc aac cca gcc acc gga ctc ggc gcc gcc cga 739Tyr Tyr Glu Ser Gly Cys Asn Pro Ala Thr Gly Leu Gly Ala Ala Arg

200 205 210cgc atc gcc cac ctc acc tac cgt ggc gaa cta gaa atc gac gaa cgc 787Arg Ile Ala His Leu Thr Tyr Arg Gly Glu Leu Glu Ile Asp Glu Arg

215 220 225ttc ggc acc aaa gcc caa aag aac gaa aac cca ctc ggt ccc tac cgc 835Phe Gly Thr Lys Ala Gln Lys Asn Glu Asn Pro Leu Gly Pro Tyr Arg230 235 240 245aag ccc gac cag cgc ttc gcc gtg gaa tcc tac ttg gac tac caa gca 883Lys Pro Asp Gln Arg Phe Ala Val Glu Ser Tyr Leu Asp Tyr Gln Ala

250 255 260gac aag cta gta cag cgt ttc gac gcc ggc tcc tac gtc ttg ctc acc 931Asp Lys Leu Val Gln Arg Phe Asp Ala Gly Ser Tyr Val Leu Leu Thr

265 270 275gac gcc ctc aac cgc cac gac att ggt cgc gac cgc gga ggc ctc aac 979Asp Ala Leu Asn Arg His Asp Ile Gly Arg Asp Arg Gly Gly Leu Asn

280 285 290aag gca ctc gaa tcc atc aaa gtt cca gtc ctt gtc gca ggc gta gat 1027Lys Ala Leu Glu Ser Ile Lys Val Pro Val Leu Val Ala Gly Val Asp

295 300 305acc gat att ttg tac ccc tac cac cag caa gaa cacctc tcc aga aac 1075Thr Asp Ile Leu Tyr Pro Tyr His Gln Gln Glu His Leu Ser Arg Asn310 315 320 325ctg gga aat cta ctg gca atg gca aaa atc gta tcc cct gtc ggc cac 1123Leu Gly Asn Leu Leu Ala Met Ala Lys Ile Val Ser Pro Val Gly His

330 335 340gat gct ttc ctc acc gaa agc cgc caa atg gat cgc atc gtg agg aac 1171Asp Ala Phe Leu Thr Glu Ser Arg Gln Met Asp Arg Ile Val Arg Asn

345 350 355ttc ttc agc ctc atc tcc cca gac gaa gac aac cct tcg acc tac atc 1219Phe Phe Ser Leu Ile Ser Pro Asp Glu Asp Asn Pro Ser Thr Tyr Ile

360 365 370gag ttc tac atc taataggtat ttacgacaaa tag 1254Glu Phe Tyr Ile

375<210>178<211>377<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>178Met Pro Thr Leu Ala Pro Ser Gly Gln Leu Glu Ile Gln Ala Ile Gly 151015 Asp Val Ser Thr Glu Ala Gly Ala Ile Ile Thr Asn Ala Glu Ile Ala

20 25 30Tyr His Arg Trp Gly Glu Tyr Arg Val Asp Lys Glu Gly Arg Ser Asn

35 40 45Val Val Leu Ile Glu His Ala Leu Thr Gly Asp Ser Asn Ala Ala Asp

50 55 60Trp Trp Ala Asp Leu Leu Gly Pro Gly Lys Ala Ile Asn Thr Asp Ile 65 70 75 80Tyr Cys Val Ile Cys Thr Asn Val Ile Gly Gly Cys Asn Gly Ser Thr

85 90 95Gly Pro Gly Ser Met His Pro Asp Gly Asn Phe Trp Gly Asn Arg Phe

100 105 110Pro Ala Thr Ser Ile Arg Asp Gln Val Asn Ala Glu Lys Gln Phe Leu

115 120 125Asp Ala Leu Gly Ile Thr Thr Val Ala Ala Val Leu Gly Gly Ser Met

130 135 140Gly Gly Ala Arg Thr Leu Glu Trp Ala Ala Met Tyr Pro Glu Thr Val145 150 155 160Gly Ala Ala Ala Val Leu Ala Val Ser Ala Arg Ala Ser Ala Trp Gln

165 170 175Ile Gly Ile Gln Ser Ala Gln Ile Lys Ala Ile Glu Asn Asp His His

180 185 190Trp His Glu Gly Asn Tyr Tyr Glu Ser Gly Cys Asn Pro Ala Thr Gly

195 200 205Leu Gly Ala Ala Arg Arg Ile Ala His Leu Thr Tyr Arg Gly Glu Leu

210 215 220Glu Ile Asp Glu Arg Phe Gly Thr Lys Ala Gln Lys Asn Glu Asn Pro225 230 235 240Leu Gly Pro Tyr Arg Lys Pro Asp Gln Arg Phe Ala Val Glu Ser Tyr

245 250 255Leu Asp Tyr Gln Ala Asp Lys Leu Val Gln Arg Phe Asp Ala Gly Ser

260 265 270Tyr Val Leu Leu Thr Asp Ala Leu Asn Arg His Asp Ile Gly Arg Asp

275 280 285Arg Gly Gly Leu Asn Lys Ala Leu Glu Ser Ile Lys Val Pro Val Leu

290 295 300Val Ala Gly Val Asp Thr Asp Ile Leu Tyr Pro Tyr His Gln Gln Glu305 310 315 320His Leu Ser Arg Asn Leu Gly Asn Leu Leu Ala Met Ala Lys Ile Val

325 330 335Ser Pro Val Gly His Asp Ala Phe Leu Thr Glu Ser Arg Gln Met Asp

340 345 350Arg Ile Val Arg Asn Phe Phe Ser Leu Ile Ser Pro Asp Glu Asp Asn

355 360 365Pro Ser Thr Tyr Ile Glu Phe Tyr Ile

370375<210>179<211>1210<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1210)<223>FRXA00403<400>179tttttcagac tcgtgagaat gcaaactaga ctagacagag ctgtccatat acactggacg 60aagttttagt cttgtccacc cagaacaggc ggttattttc atg ccc acc ctc gcg 115

Met Pro Thr Leu Ala

1 5cct tca ggt caa ctt gaa atc caa gcg atc ggt gat gtc tcc acc gaa 163Pro Ser Gly Gln Leu Glu Ile Gln Ala Ile Gly Asp Val Ser Thr Glu

10 15 20gcc gga gca atc att aca aac gct gaa atc gcc tat cac cgc tgg ggt 211Ala Gly Ala Ile Ile Thr Asn Ala Glu Ile Ala Tyr His Arg Trp Gly

25 30 35gaa tac cgc gta gat aaa gaa gga cgc agc aat gtc gtt ctc atc gaa 259Glu Tyr Arg Val Asp Lys Glu Gly Arg Ser Asn Val Val Leu Ile Glu

40 45 50cac gcc ctc act gga gat tcc aac gca gcc gat tgg tgg gct gac ttg 307His Ala Leu Thr Gly Asp Ser Asn Ala Ala Asp Trp Trp Ala Asp Leu

55 60 65ctc ggt ccc ggc aaa gcc atc aac act gat att tac tgc gtg atc tgt 355Leu Gly Pro Gly Lys Ala Ile Asn Thr Asp Ile Tyr Cys Val Ile Cys 70 75 80 85acc aac gtc atc ggt ggt tgc aac ggt tcc acc gga cct ggc tcc atg 403Thr Asn Val Ile Gly Gly Cys Asn Gly Ser Thr Gly Pro Gly Ser Met

90 95 100cat cca gat gga aat ttc tgg ggt aat cgc ttc ccc gcc acg tcc att 451His Pro Asp Gly Asn Phe Trp Gly Asn Arg Phe Pro Ala Thr Ser Ile

105 110 115cgt gat cag gta aac gcc gaa aaa caa ttc ctc gac gca ctc ggc atc 499Arg Asp Gln Val Asn Ala Glu Lys Gln Phe Leu Asp Ala Leu Gly Ile

120 125 130acc acg gtc gcc gca gta ctt ggt ggt tcc atg ggt ggt gcc cgc acc 547Thr Thr Val Ala Ala Val Leu Gly Gly Ser Met Gly Gly Ala Arg Thr

135 140 145cta gag tgg gcc gca atg tac cca gaa act gtt ggc gca gct gct gtt 595Leu Glu Trp Ala Ala Met Tyr Pro Glu Thr Val Gly Ala Ala Ala Val150 155 160 165ctt gca gtt tct gca cgc gcc agc gcc tgg caa atc ggc att caa tcc 643Leu Ala Val Ser Ala Arg Ala Ser Ala Trp Gln Ile Gly Ile Gln Ser

170 175 180gcc caa att aag gcg att gaa aac gac cac cac tgg cac gaa ggc aac 691Ala Gln Ile Lys Ala Ile Glu Asn Asp His His Trp His Glu Gly Asn

185 190 195tac tac gaa tcc ggc tgc aac cca gcc acc gga ctc ggc gcc gcc cga 739Tyr Tyr Glu Ser Gly Cys Asn Pro Ala Thr Gly Leu Gly Ala Ala Arg

200 205 210cgc atc gcc cac ctc acc tac cgt ggc gaa cta gaa atc gac gaa cgc 787Arg Ile Ala His Leu Thr Tyr Arg Gly Glu Leu Glu Ile Asp Glu Arg

215 220 225ttc ggc acc aaa gcc caa aag aac gaa aac cca ctc ggt ccc tac cgc 835Phe Gly Thr Lys Ala Gln Lys Asn Glu Asn Pro Leu Gly Pro Tyr Arg230 235 240245aag ccc gac cag cgc ttc gcc gtg gaa tcc tac ttg gac tac caa gca 883Lys Pro Asp Gln Arg Phe Ala Val Glu Ser Tyr Leu Asp Tyr Gln Ala

250 255 260gac aag cta gta cag cgt ttc gac gcc ggc tcc tac gtc ttg ctc acc 931Asp Lys Leu Val Gln Arg Phe Asp Ala Gly Ser Tyr Val Leu Leu Thr

265 270 275gac gcc ctc aac cgc cac gac att ggt cgc gac cgc gga ggc ctc aac 979Asp Ala Leu Asn Arg His Asp Ile Gly Arg Asp Arg Gly Gly Leu Asn

280 285 290aag gca ctc gaa tcc atc aaa gtt cca gtc ctt gtc gca ggc gta gat 1027Lys Ala Leu Glu Ser Ile Lys Val Pro Val Leu Val Ala Gly Val Asp

295 300 305acc gat att ttg tac ccc tac cac cag caa gaa cac ctc tcc aga aac 1075Thr Asp Ile Leu Tyr Pro Tyr His Gln Gln Glu His Leu Ser Arg Asn310 315 320 325ctg gga aat cta ctg gca atg gca aaa atc gta tcc cct gtc ggc cac 1123Leu Gly Asn Leu Leu Ala Met Ala Lys Ile Val Ser Pro Val Gly His

330 335 340gat gct ttc ctc acc gaa agc cgc caa atg gat cgc atc gtg agg aac 1171Asp Ala Phe Leu Thr Glu Ser Arg Gln Met Asp Arg Ile Val Arg Asn

345 350 355ttc ttc agc ctc atc tcc cca gac gaa gac aac cct tcg 1210Phe Phe Ser Leu Ile Ser Pro Asp Glu Asp Asn Pro Ser

360365370<210>180<211>370<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>180Met Pro Thr Leu Ala Pro Ser Gly Gln Leu Glu Ile Gln Ala Ile Gly 151015 Asp Val Ser Thr Glu Ala Gly Ala Ile Ile Thr Asn Ala Glu Ile Ala

20 2530Tyr His Arg Trp Gly Glu Tyr Arg Val Asp Lys Glu Gly Arg Ser Asn

35 40 45Val Val Leu Ile Glu His Ala Leu Thr Gly Asp Ser Asn Ala Ala Asp

50 55 60Trp Trp Ala Asp Leu Leu Gly Pro Gly Lys Ala Ile Asn Thr Asp Ile 65 70 75 80Tyr Cys Val Ile Cys Thr Asn Val Ile Gly Gly Cys Asn Gly Ser Thr

85 90 95Gly Pro Gly Ser Met His Pro Asp Gly Asn Phe Trp Gly Asn Arg Phe

100 105 110Pro Ala Thr Ser Ile Arg Asp Gln Val Asn Ala Glu Lys Gln Phe Leu

115 120 125Asp Ala Leu Gly Ile Thr Thr Val Ala Ala Val Leu Gly Gly Ser Met

130 135 140Gly Gly Ala Arg Thr Leu Glu Trp Ala Ala Met Tyr Pro Glu Thr Val145 150 155 160Gly Ala Ala Ala Val Leu Ala Val Ser Ala Arg Ala Ser Ala Trp Gln

165 170 175Ile Gly Ile Gln Ser Ala Gln Ile Lys Ala Ile Glu Asn Asp His His

180 185 190Trp His Glu Gly Asn Tyr Tyr Glu Ser Gly Cys Asn Pro Ala Thr Gly

195 200 205Leu Gly Ala Ala Arg Arg Ile Ala His Leu Thr Tyr Arg Gly Glu Leu

210 215 220Glu Ile Asp Glu Arg Phe Gly Thr Lys Ala Gln Lys Asn Glu Asn Pro225 230 235 240Leu Gly Pro Tyr Arg Lys Pro Asp Gln Arg Phe Ala Val Glu Ser Tyr

245 250 255Leu Asp TyrGln Ala Asp Lys Leu Val Gln Arg Phe Asp Ala Gly Ser

260 265 270Tyr Val Leu Leu Thr Asp Ala Leu Asn Arg His Asp Ile Gly Arg Asp

275 280 285Arg Gly Gly Leu Asn Lys Ala Leu Glu Ser Ile Lys Val Pro Val Leu

290 295 300Val Ala Gly Val Asp Thr Asp Ile Leu Tyr Pro Tyr His Gln Gln Glu305 310 315 320His Leu Ser Arg Asn Leu Gly Asn Leu Leu Ala Met Ala Lys Ile Val

325 330 335Ser Pro Val Gly His Asp Ala Phe Leu Thr Glu Ser Arg Gln Met Asp

340 345 350Arg Ile Val Arg Asn Phe Phe Ser Leu Ile Ser Pro Asp Glu Asp Asn

355 360 365Pro Ser

370<210>181<211>771<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (748)<223>RXC01207<400>181cttcatgatc tcaccggcag agcgcgtttt gttacagcgc gtaaactgtg actttgaaaa 60atttttgaac aatccgtaca ccaacttcag gagaaaaaca gtg agc aga atc tat 115

Val Ser Arg Ile Tyr

1 5gac tgt gcc gac caa gac tcc cgt gca gca ggc cta aag gcg gct gtc 163Asp Cys Ala Asp Gln Asp Ser Arg Ala Ala Gly Leu Lys Ala Ala Val

10 15 20gat gca gtc aaa gcc ggt cag ctc gtt gtc ctt ccc acg gat acc ctt 211Asp Ala Val Lys Ala Gly Gln Leu Val Val Leu Pro Thr Asp Thr Leu

25 30 35tat ggactc ggc tgc gac gct ttc aac aac gag gca gta gcc aac ctt 259Tyr Gly Leu Gly Cys Asp Ala Phe Asn Asn Glu Ala Val Ala Asn Leu

40 45 50ctg gcc acc aaa cac cgt ggc ccc gat atg ccc gtt cca gtg ctc gtc 307Leu Ala Thr Lys His Arg Gly Pro Asp Met Pro Val Pro Val Leu Val

55 60 65ggc agc tgg gac acc att caa gga ctt gtg cac tcc tat tct gcg cag 355Gly Ser Trp Asp Thr Ile Gln Gly Leu Val His Ser Tyr Ser Ala Gln 70 75 80 85gca aaa gcg ctt gtg gag gcg ttc tgg cct ggt gga ctg tcc atc atc 403Ala Lys Ala Leu Val Glu Ala Phe Trp Pro Gly Gly Leu Ser Ile Ile

90 95 100gtt ccg cag gca cca agc ctt ccg tgg aac ctt ggc gat acc cgt ggc 451Val Pro Gln Ala Pro Ser Leu Pro Trp Asn Leu Gly Asp Thr Arg Gly

105 110 115acc gta atg ctg cgc atg cca ctg cac cca gtt gcc att gaa ttg ctg 499Thr Val Met Leu Arg Met Pro Leu His Pro Val Ala Ile Glu Leu Leu

120 125 130cgc caa acc gga cca atg gct gtc tcc tcc gcc aac atc tcc gga cat 547Arg Gln Thr Gly Pro Met Ala Val Ser Ser Ala Asn Ile Ser Gly His

135 140 145act cct cca acc acc gtg ctg gag gct cgt cag cag ctc aac caa aat 595Thr Pro Pro Thr Thr Val Leu Glu Ala Arg Gln Gln Leu Asn Gln Asn150 155 160 165gtc gct gtc tac ctc gat ggt ggc gaa tgc gcg ctg gcc acc cct tca 643Val Ala Val Tyr Leu Asp Gly Gly Glu Cys Ala Leu Ala Thr Pro Ser

170 175 180acc atc gtg gat att tca ggc ccc gca cca aag att ttg cgt gag ggt 691Thr Ile Val Asp Ile Ser Gly Pro Ala Pro Lys Ile Leu ArgGlu Gly

185 190 195gcc atc agc gca gaa cgc gtt ggc gaa gta ctt gga gtg tcg gca gaa 739Ala Ile Ser Ala Glu Arg Val Gly Glu Val Leu Gly Val Ser Ala Glu

200 205 210agc ctg cgc taaatgggag tcggtttcgc ggg 771Ser Leu Arg

215<210>182<211>216<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>182Val Ser Arg Ile Tyr Asp Cys Ala Asp Gln Asp Ser Arg Ala Ala Gly 151015 Leu Lys Ala Ala Val Asp Ala Val Lys Ala Gly Gln Leu Val Val Leu

20 25 30Pro Thr Asp Thr Leu Tyr Gly Leu Gly Cys Asp Ala Phe Asn Asn Glu

35 40 45Ala Val Ala Asn Leu Leu Ala Thr Lys His Arg Gly Pro Asp Met Pro

50 55 60Val Pro Val Leu Val Gly Ser Trp Asp Thr Ile Gln Gly Leu Val His 65 70 75 80Ser Tyr Ser Ala Gln Ala Lys Ala Leu Val Glu Ala Phe Trp Pro Gly

85 90 95Gly Leu Ser Ile Ile Val Pro Gln Ala Pro Ser Leu Pro Trp Asn Leu

100 105 110Gly Asp Thr Arg Gly Thr Val Met Leu Arg Met Pro Leu His Pro Val

115 120 125Ala Ile Glu Leu Leu Arg Gln Thr Gly Pro Met Ala Val Ser Ser Ala

130 135 140Asn Ile Ser Gly His Thr Pro Pro Thr Thr Val Leu Glu Ala Arg Gln145 150 155 160Gln Leu Asn Gln Asn Val Ala Val Tyr Leu Asp Gly Gly Glu Cys Ala

165170 175Leu Ala Thr Pro Ser Thr Ile Val Asp Ile Ser Gly Pro Ala Pro Lys

180 185 190Ile Leu Arg Glu Gly Ala Ile Ser Ala Glu Arg Val Gly Glu Val Leu

195 200 205Gly Val Ser Ala Glu Ser Leu Arg

210215<210>183<211>1419<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1396)<223>RXC00152<400>183gtcattgata tccaaggcac gaccgcgatt gtatggaaag aagcctaaat ttttaacaat 60caaatagtac tggccattcc caactaaaac tggagtaacg atg aca gga cta atc 115

Met Thr Gly Leu Ile

1 5ctc gcc ata gtt ttc ctg gtc ttt gtc gcc gtc gtg gtg atc aag tcc 163Leu Ala Ile Val Phe Leu Val Phe Val Ala Val Val Val Ile Lys Ser

10 15 20ata gcc ctg att ccc cag ggt gaa gcc gcc gtc att gaa cgc ctt ggt 211Ile Ala Leu Ile Pro Gln Gly Glu Ala Ala Val Ile Glu Arg Leu Gly

25 30 35agc tac acc cgc acc gtt tca ggt ggc ctg acc ctg ctg gtt cca ttc 259Ser Tyr Thr Arg Thr Val Ser Gly Gly Leu Thr Leu Leu Val Pro Phe

40 45 50gtg gac cga gta cgc gca agg atc gac acc cgt gag cgc gtg gtc tca 307Val Asp Arg Val Arg Ala Arg Ile Asp Thr Arg Glu Arg Val Val Ser

55 60 65ttc cca ccg cag gct gtt att acc caa gac aac ctg acc gtg gcc atc 355Phe Pro Pro Gln Ala Val Ile Thr Gln Asp Asn Leu Thr Val Ala Ile 70 75 80 85gat atc gtg gtg acc ttc caa atc aac gaa cca gag cgc gcc atc tac 403Asp Ile Val Val Thr Phe Gln Ile Asn Glu Pro Glu Arg Ala Ile Tyr

90 95 100ggc gtg gac aac tac atc gtc ggt gtg gag cag att tct gta gca aca 451Gly Val Asp Asn Tyr Ile Val Gly Val Glu Gln Ile Ser Val Ala Thr

105 110 115ctt cga gac gtt gtc ggt ggc atg acc ctg gaa gaa acc ctc act tca 499Leu Arg Asp Val Val Gly Gly Met Thr Leu Glu Glu Thr Leu Thr Ser

120 125 130cgt gac gtg atc aac cgc cgc ctc cgt ggc gag ctc gat gca gca acc 547Arg Asp Val Ile Asn Arg Arg Leu Arg Gly Glu Leu Asp Ala Ala Thr

135 140 145acc aaa tgg ggc ctg cgc atc agc cgt gtg gaa cta aag gca att gat 595Thr Lys Trp Gly Leu Arg Ile Ser Arg Val Glu Leu Lys Ala Ile Asp150 155 160 165ccg cca cca tcc atc cag caa tcg atg gaa aag cag atg aag gca gac 643Pro Pro Pro Ser Ile Gln Gln Ser Met Glu Lys Gln Met Lys Ala Asp

170 175 180cgt gaa aag cgc gcc acc att ttg acc gca gaa ggt cag cgc gaa gcc 691Arg Glu Lys Arg Ala Thr Ile Leu Thr Ala Glu Gly Gln Arg Glu Ala

185 190 195gac atc aaa act gcc gaa ggt gaa aag caa gcc aag atc ctc caa gct 739Asp Ile Lys Thr Ala Glu Gly Glu Lys Gln Ala Lys Ile Leu Gln Ala

200 205 210gag ggt gaa aag cac gca tcc atc ctg aac gca gaa gca gaa cgc caa 787Glu Gly Glu Lys His Ala Ser Ile Leu Asn Ala Glu Ala Glu Arg Gln

215 220 225gcg atg atc ctg cgc gcc gaa ggt gaa cgc gca gca cgc tac ctc cag 835Ala Met Ile Leu Arg Ala Glu Gly Glu Arg Ala AlaArg Tyr Leu Gln230 235 240 245gcg cag ggt gaa gcc cga gca atc caa aag gtc aac gca gca atc aag 883Ala Gln Gly Glu Ala Arg Ala Ile Gln Lys Val Asn Ala Ala Ile Lys

250 255 260tct gcc aag ttg acc cca gag gtt ctt gct tat caa tac ctc gaa aag 931Ser Ala Lys Leu Thr Pro Glu Val Leu Ala Tyr Gln Tyr Leu Glu Lys

265 270 275ctt cct aag atc gca gag ggc aac gcc tcc aag atg tgg gtc atc cca 979Leu Pro Lys Ile Ala Glu Gly Asn Ala Ser Lys Met Trp Val Ile Pro

280 285 290agc cag ttc tcc gat tct ctg gaa ggt ttt gcg aag cag ttc ggc gca 1027Ser Gln Phe Ser Asp Ser Leu Glu Gly Phe Ala Lys Gln Phe Gly Ala

295 300 305aag gat gca gaa ggt gtc ttc cgc tac gaa cca aac acc gtg gat gaa 1075Lys Asp Ala Glu Gly Val Phe Arg Tyr Glu Pro Asn Thr Val Asp Glu310 315 320 325gaa acc cgc gac atc gca aac gcc gac aac gtg gaa gac tgg ttc tcc 1123Glu Thr Arg Asp Ile Ala Asn Ala Asp Asn Val Glu Asp Trp Phe Ser

330 335 340acc gaa tca gac cct gaa atc gca gca gca gtc gcc gca gca aac gcc 1171Thr Glu Ser Asp Pro Glu Ile Ala Ala Ala Val Ala Ala Ala Asn Ala

345 350 355gtg gcc aac aag cca gtc gat cca gaa ccc ggt gag atc ctt tcc aag 1219Val Ala Asn Lys Pro Val Asp Pro Glu Pro Gly Glu Ile Leu Ser Lys

360 365 370aag acc gca cga cgc gtt gaa cct gaa gca gta ttg gag gct ttg caa 1267Lys Thr Ala Arg Arg Val Glu Pro Glu Ala Val Leu Glu Ala Leu Gln

375 380 385aac ggaacc act aca caa cct gag gtt gag gca gca cct cct acc gca 1315Asn Gly Thr Thr Thr Gln Pro Glu Val Glu Ala Ala Pro Pro Thr Ala390 395 400 405aac ttc gcc caa gaa ttc cct gca cca cag gca aac cct gaa gat tac 1363Asn Phe Ala Gln Glu Phe Pro Ala Pro Gln Ala Asn Pro Glu Asp Tyr

410 415 420tcc gac caa cac cga gag aat cct tac gga aac taatcaggca taagaaaagg 1416Ser Asp Gln His Arg Glu Asn Pro Tyr Gly Asn

425430 cgg 1419<210>184<211>432<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>184Met Thr Gly Leu Ile Leu Ala Ile Val Phe Leu Val Phe Val Ala Val 151015 Val Val Ile Lys Ser Ile Ala Leu Ile Pro Gln Gly Glu Ala Ala Val

20 25 30Ile Glu Arg Leu Gly Ser Tyr Thr Arg Thr Val Ser Gly Gly Leu Thr

35 40 45Leu Leu Val Pro Phe Val Asp Arg Val Arg Ala Arg Ile Asp Thr Arg

50 55 60Glu Arg Val Val Ser Phe Pro Pro Gln Ala Val Ile Thr Gln Asp Asn 65 70 75 80Leu Thr Val Ala Ile Asp Ile Val Val Thr Phe Gln Ile Asn Glu Pro

85 90 95Glu Arg Ala Ile Tyr Gly Val Asp Asn Tyr Ile Val Gly Val Glu Gln

100 105 110Ile Ser Val Ala Thr Leu Arg Asp Val Val Gly Gly Met Thr Leu Glu

115 120 125Glu Thr Leu Thr Ser Arg Asp Val Ile Asn Arg Arg Leu Arg Gly Glu

130 135 140Leu Asp Ala Ala Thr Thr Lys Trp Gly Leu Arg Ile Ser Arg Val Glu145 150155 160Leu Lys Ala Ile Asp Pro Pro Pro Ser Ile Gln Gln Ser Met Glu Lys

165 170 175Gln Met Lys Ala Asp Arg Glu Lys Arg Ala Thr Ile Leu Thr Ala Glu

180 185 190Gly Gln Arg Glu Ala Asp Ile Lys Thr Ala Glu Gly Glu Lys Gln Ala

195 200 205Lys Ile Leu Gln Ala Glu Gly Glu Lys His Ala Ser Ile Leu Asn Ala

210 215 220Glu Ala Glu Arg Gln Ala Met Ile Leu Arg Ala Glu Gly Glu Arg Ala225 230 235 240Ala Arg Tyr Leu Gln Ala Gln Gly Glu Ala Arg Ala Ile Gln Lys Val

245 250 255Asn Ala Ala Ile Lys Ser Ala Lys Leu Thr Pro Glu Val Leu Ala Tyr

260 265 270Gln Tyr Leu Glu Lys Leu Pro Lys Ile Ala Glu Gly Asn Ala Ser Lys

275 280 285Met Trp Val Ile Pro Ser Gln Phe Ser Asp Ser Leu Glu Gly Phe Ala

290 295 300Lys Gln Phe Gly Ala Lys Asp Ala Glu Gly Val Phe Arg Tyr Glu Pro305 310 315 320Asn Thr Val Asp Glu Glu Thr Arg Asp Ile Ala Asn Ala Asp Asn Val

325 330 335Glu Asp Trp Phe Ser Thr Glu Ser Asp Pro Glu Ile Ala Ala Ala Val

340 345 350Ala Ala Ala Asn Ala Val Ala Asn Lys Pro Val Asp Pro Glu Pro Gly

355 360 365Glu Ile Leu Ser Lys Lys Thr Ala Arg Arg Val Glu Pro Glu Ala Val

370 375 380Leu Glu Ala Leu Gln Asn Gly Thr Thr Thr Gln Pro Glu Val Glu Ala385 390 395 400Ala Pro Pro Thr Ala Asn Phe Ala Gln Glu Phe Pro Ala Pro Gln Ala

405 410 415Asn Pro Glu Asp Tyr Ser Asp Gln His Arg Glu Asn Pro Tyr Gly Asn

420425430<210>185<211>1170<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1147)<223>RXA00115<400>185tggattctcg agtctgtaca cccttgatca aagcccgagt gttccgtaga ttaactttgt 60cgtatattgt gacctacacc ccatactgtt aggagttttc atg ctc gac aat agt 115

Met Leu Asp Asn Ser

1 5ttt tac acc gca gag gtt cag ggc cca tac gaa acc gct tcc att ggc 163Phe Tyr Thr Ala Glu Val Gln Gly Pro Tyr Glu Thr Ala Ser Ile Gly

10 15 20cgg ctc gaa ctc gaa gaa ggg ggt gtg att gag gat tgc tgg ttg gct 211Arg Leu Glu Leu Glu Glu Gly Gly Val Ile Glu Asp Cys Trp Leu Ala

25 30 35tac gct aca gct gga acg ctc aac gag gac aag tcc aac gcc atc ctc 259Tyr Ala Thr Ala Gly Thr Leu Asn Glu Asp Lys Ser Asn Ala Ile Leu

40 45 50att ccg acg tgg tac tcc gga acc cat cag acc tgg ttc cag cag tac 307Ile Pro Thr Trp Tyr Ser Gly Thr His Gln Thr Trp Phe Gln Gln Tyr

55 60 65atc ggc act gat cat gcg ctg gat cca tca aag tat ttc atc atc tcc 355Ile Gly Thr Asp His Ala Leu Asp Pro Ser Lys Tyr Phe Ile Ile Ser 70 75 8085atc aac caa atc ggt aat ggt ttg tcg gtc tcc cct gcc aac acg gct 403Ile Asn Gln Ile Gly Asn Gly Leu Ser Val Ser Pro Ala Asn Thr Ala

90 95 100gat gac agc atc tcg atg tcc aag ttc ccg aat gtt cgc att ggt gat 451Asp Asp Ser Ile Ser Met Ser Lys Phe Pro Asn Val Arg Ile Gly Asp

105 110 115gat gtc gtt gcc cag gac cgg ctc ttg cgc caa gag ttt ggt att acc 499Asp Val Val Ala Gln Asp Arg Leu Leu Arg Gln Glu Phe Gly Ile Thr

120 125 130gag ctc ttt gcc gtc gtt ggt ggt tcg atg ggt gcg cag caa acc tat 547Glu Leu Phe Ala Val Val Gly Gly Ser Met Gly Ala Gln Gln Thr Tyr

135 140 145gag tgg att gtt cgc ttc cct gac caa gtt cat cga gca gct ccg atc 595Glu Trp Ile Val Arg Phe Pro Asp Gln Val His Arg Ala Ala Pro Ile150 155 160 165gcg ggc act gcg aag aac act cct cat gat ttc atc ttc acc cag act 643Ala Gly Thr Ala Lys Asn Thr Pro His Asp Phe Ile Phe Thr Gln Thr

170 175 180ctt aat gag acc gtt gag gcc gat cca ggg ttc aat ggc ggc gaa tac 691Leu Asn Glu Thr Val Glu Ala Asp Pro Gly Phe Asn Gly Gly Glu Tyr

185 190 195tcc tcc cat gaa gag gta gct gat gga ctt cgc cgt caa tcg cat ctt 739Ser Ser His Glu Glu Val Ala Asp Gly Leu Arg Arg Gln Ser His Leu

200 205 210tgg gct gcc atg gga ttt tcc aca gag ttc tgg aag cag gag gca tgg 787Trp Ala Ala Met Gly Phe Ser Thr Glu Phe Trp Lys Gln Glu Ala Trp

215 220 225cgt cgc ctg gga ctt gaa agt aag gag tca gtg ctc gcg gac ttc ctg 835Arg ArgLeu Gly Leu Glu Ser Lys Glu Ser Val Leu Ala Asp Phe Leu230 235 240 245gat ccg ctg ttc atg tcc atg gat cct aat acc ttg ctc aac aac gct 883Asp Pro Leu Phe Met Ser Met Asp Pro Asn Thr Leu Leu Asn Asn Ala

250 255 260tgg aag tgg cag cat ggc gat gtc tct cgc cac acc ggc ggc gac ttg 931Trp Lys Trp Gln His Gly Asp Val Ser Arg His Thr Gly Gly Asp Leu

265 270 275gca gcg gct ctt ggc cga gtg aag gct aag acc ttc gtt atg ccc atc 979Ala Ala Ala Leu Gly Arg Val Lys Ala Lys Thr Phe Val Met Pro Ile

280 285 290agc gag gac atg ttc ttt cct gtt cgt gac tgt gcc gca gaa caa gca 1027Ser Glu Asp Met Phe Phe Pro Val Arg Asp Cys Ala Ala Glu Gln Ala

295 300 305ctc atc cca ggc agc gag ctt cga gtg atc gaa gac atc gcc ggt cac 1075Leu Ile Pro Gly Ser Glu Leu Arg Val Ile Glu Asp Ile Ala Gly His310 315 320 325ctt ggg ctt ttt aac gtc tct gag aat tac atc cca cag atc gac aaa 1123Leu Gly Leu Phe Asn Val Ser Glu Asn Tyr Ile Pro Gln Ile Asp Lys

330 335 340aat ctg aaa gag ctg ttc gag agc taaacactga tgtcaaagag cct 1170Asn Leu Lys Glu Leu Phe Glu Ser

345<210>186<211>349<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>186Met Leu Asp Asn Ser Phe Tyr Thr Ala Glu Val Gln Gly Pro Tyr Glu 151015 Thr Ala Ser Ile Gly Arg Leu Glu Leu Glu Glu Gly Gly Val Ile Glu

20 25 30Asp Cys Trp Leu Ala Tyr Ala Thr Ala Gly Thr Leu Asn Glu Asp Lys

35 4045Ser Asn Ala Ile Leu Ile Pro Thr Trp Tyr Ser Gly Thr His Gln Thr

50 55 60Trp Phe Gln Gln Tyr Ile Gly Thr Asp His Ala Leu Asp Pro Ser Lys 65 70 75 80Tyr Phe Ile Ile Ser Ile Asn Gln Ile Gly Asn Gly Leu Ser Val Ser

85 90 95Pro Ala Asn Thr Ala Asp Asp Ser Ile Ser Met Ser Lys Phe Pro Asn

100 105 110Val Arg Ile Gly Asp Asp Val Val Ala Gln Asp Arg Leu Leu Arg Gln

115 120 125Glu Phe Gly Ile Thr Glu Leu Phe Ala Val Val Gly Gly Ser Met Gly

130 135 140Ala Gln Gln Thr Tyr Glu Trp Ile Val Arg Phe Pro Asp Gln Val His145 150 155 160Arg Ala Ala Pro Ile Ala Gly Thr Ala Lys Asn Thr Pro His Asp Phe

165 170 175Ile Phe Thr Gln Thr Leu Asn Glu Thr Val Glu Ala Asp Pro Gly Phe

180 185 190Asn Gly Gly Glu Tyr Ser Ser His Glu Glu Val Ala Asp Gly Leu Arg

195 200 205Arg Gln Ser His Leu Trp Ala Ala Met Gly Phe Ser Thr Glu Phe Trp

210 215 220Lys Gln Glu Ala Trp Arg Arg Leu Gly Leu Glu Ser Lys Glu Ser Val225 230 235 240Leu Ala Asp Phe Leu Asp Pro Leu Phe Met Ser Met Asp Pro Asn Thr

245 250 255Leu Leu Asn Asn Ala Trp Lys Trp Gln His Gly Asp Val Ser Arg His

260 265270Thr Gly Gly Asp Leu Ala Ala Ala Leu Gly Arg Val Lys Ala Lys Thr

275 280 285Phe Val Met Pro Ile Ser Glu Asp Met Phe Phe Pro Val Arg Asp Cys

290 295 300Ala Ala Glu Gln Ala Leu Ile Pro Gly Ser Glu Leu Arg Val Ile Glu305 310 315 320Asp Ile Ala Gly His Leu Gly Leu Phe Asn Val Ser Glu Asn Tyr Ile

325 330 335Pro Gln Ile Asp Lys Asn Leu Lys Glu Leu Phe Glu Ser

340345<210>187<211>1254<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1231)<223>RXN00403<400>187tttttcagac tcgtgagaat gcaaactaga ctagacagag ctgtccatat acactggacg 60aagttttagt cttgtccacc cagaacaggc ggttattttc atg ccc acc ctc gcg 115

Met Pro Thr Leu Ala

1 5cct tca ggt caa ctt gaa atc caa gcg atc ggt gat gtc tcc acc gaa 163Pro Ser Gly Gln Leu Glu Ile Gln Ala Ile Gly Asp Val Ser Thr Glu

10 15 20gcc gga gca atc att aca aac gct gaa atc gcc tat cac cgc tgg ggt 211Ala Gly Ala Ile Ile Thr Asn Ala Glu Ile Ala Tyr His Arg Trp Gly

25 30 35gaa tac cgc gta gat aaa gaa gga cgc agc aat gtc gtt ctc atc gaa 259Glu Tyr Arg Val Asp Lys Glu Gly Arg Ser Asn Val Val Leu Ile Glu

40 45 50cac gcc ctc act gga gat tcc aac gca gcc gat tgg tgg gct gac ttg 307His Ala Leu Thr Gly Asp Ser Asn Ala Ala Asp Trp Trp Ala Asp Leu

5560 65ctc ggt ccc ggc aaa gcc atc aac act gat att tac tgc gtg atc tgt 355Leu Gly Pro Gly Lys Ala Ile Asn Thr Asp Ile Tyr Cys Val Ile Cys 70 75 80 85acc aac gtc atc ggt ggt tgc aac ggt tcc acc gga cct ggc tcc atg 403Thr Asn Val Ile Gly Gly Cys Asn Gly Ser Thr Gly Pro Gly Ser Met

90 95 100cat cca gat gga aat ttc tgg ggt aat cgc ttc ccc gcc acg tcc att 451His Pro Asp Gly Asn Phe Trp Gly Asn Arg Phe Pro Ala Thr Ser Ile

105 110 115cgt gat cag gta aac gcc gaa aaa caa ttc ctc gac gca ctc ggc atc 499Arg Asp Gln Val Asn Ala Glu Lys Gln Phe Leu Asp Ala Leu Gly Ile

120 125 130acc acg gtc gcc gca gta ctt ggt ggt tcc atg ggt ggt gcc cgc acc 547Thr Thr Val Ala Ala Val Leu Gly Gly Ser Met Gly Gly Ala Arg Thr

135 140 145cta gag tgg gcc gca atg tac cca gaa act gtt ggc gca gct gct gtt 595Leu Glu Trp Ala Ala Met Tyr Pro Glu Thr Val Gly Ala Ala Ala Val150 155 160 165ctt gca gtt tct gca cgc gcc agc gcc tgg caa atc ggc att caa tcc 643Leu Ala Val Ser Ala Arg Ala Ser Ala Trp Gln Ile Gly Ile Gln Ser

170 175 180gcc caa att aag gcg att gaa aac gac cac cac tgg cac gaa ggc aac 691Ala Gln Ile Lys Ala Ile Glu Asn Asp His His Trp His Glu Gly Asn

185 190 195tac tac gaa tcc ggc tgc aac cca gcc acc gga ctc ggc gcc gcc cga 739Tyr Tyr Glu Ser Gly Cys Asn Pro Ala Thr Gly Leu Gly Ala Ala Arg

200 205 210cgc atc gcc cac ctc acc tac cgt ggc gaa cta gaa atc gac gaa cgc 787Arg Ile Ala His Leu Thr Tyr Arg Gly Glu Leu Glu Ile Asp Glu Arg

215 220 225ttc ggc acc aaa gcc caa aag aac gaa aac cca ctc ggt ccc tac cgc 835Phe Gly Thr Lys Ala Gln Lys Asn Glu Asn Pro Leu Gly Pro Tyr Arg230 235 240 245aag ccc gac cag cgc ttc gcc gtg gaa tcc tac ttg gac tac caa gca 883Lys Pro Asp Gln Arg Phe Ala Val Glu Ser Tyr Leu Asp Tyr Gln Ala

250 255 260gac aag cta gta cag cgt ttc gac gcc ggc tcc tac gtc ttg ctc acc 931Asp Lys Leu Val Gln Arg Phe Asp Ala Gly Ser Tyr Val Leu Leu Thr

265 270 275gac gcc ctc aac cgc cac gac att ggt cgc gac cgc gga ggc ctc aac 979Asp Ala Leu Asn Arg His Asp Ile Gly Arg Asp Arg Gly Gly Leu Asn

280 285 290aag gca ctc gaa tcc atc aaa gtt cca gtc ctt gtc gca ggc gta gat 1027Lys Ala Leu Glu Ser Ile Lys Val Pro Val Leu Val Ala Gly Val Asp

295 300 305acc gat att ttg tac ccc tac cac cag caa gaa cac ctc tcc aga aac 1075Thr Asp Ile Leu Tyr Pro Tyr His Gln Gln Glu His Leu Ser Arg Asn310 315 320 325ctg gga aat cta ctg gca atg gca aaa atc gta tcc cct gtc ggc cac 1123Leu Gly Asn Leu Leu Ala Met Ala Lys Ile Val Ser Pro Val Gly His

330 335 340gat gct ttc ctc acc gaa agc cgc caa atg gat cgc atc gtg agg aac 1171Asp Ala Phe Leu Thr Glu Ser Arg Gln Met Asp Arg Ile Val Arg Asn

345 350 355ttc ttc agc ctc atc tcc cca gac gaa gac aac cct tcg acc tac atc 1219Phe Phe Ser Leu Ile Ser Pro Asp Glu Asp Asn Pro Ser Thr Tyr Ile

360 365370gag ttc tac atc taataggtat ttacgacaaa tag 1254Glu Phe Tyr Ile

375<210>188<211>377<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>188Met Pro Thr Leu Ala Pro Ser Gly Gln Leu Glu Ile Gln Ala Ile Gly 151015 Asp Val Ser Thr Glu Ala Gly Ala Ile Ile Thr Asn Ala Glu Ile Ala

20 25 30Tyr His Arg Trp Gly Glu Tyr Arg Val Asp Lys Glu Gly Arg Ser Asn

35 40 45Val Val Leu Ile Glu His Ala Leu Thr Gly Asp Ser Asn Ala Ala Asp

50 55 60Trp Trp Ala Asp Leu Leu Gly Pro Gly Lys Ala Ile Asn Thr Asp Ile 65 70 75 80Tyr Cys Val Ile Cys Thr Asn Val Ile Gly Gly Cys Asn Gly Ser Thr

85 90 95Gly Pro Gly Ser Met His Pro Asp Gly Asn Phe Trp Gly Asn Arg Phe

100 105 110Pro Ala Thr Ser Ile Arg Asp Gln Val Asn Ala Glu Lys Gln Phe Leu

115 120 125Asp Ala Leu Gly Ile Thr Thr Val Ala Ala Val Leu Gly Gly Ser Met

130 135 140Gly Gly Ala Arg Thr Leu Glu Trp Ala Ala Met Tyr Pro Glu Thr Val145 150 155 160Gly Ala Ala Ala Val Leu Ala Val Ser Ala Arg Ala Ser Ala Trp Gln

165 170 175Ile Gly Ile Gln Ser Ala Gln Ile Lys Ala Ile Glu Asn Asp His His

180 185 190Trp His Glu Gly Asn Tyr Tyr Glu Ser Gly Cys Asn Pro Ala Thr Gly

195 200 205Leu Gly Ala Ala Arg Arg Ile Ala His Leu Thr Tyr Arg Gly Glu Leu

210 215 220Glu Ile Asp Glu Arg Phe Gly Thr Lys Ala Gln Lys Asn Glu Asn Pro225 230 235 240Leu Gly Pro Tyr Arg Lys Pro Asp Gln Arg Phe Ala Val Glu Ser Tyr

245 250 255Leu Asp Tyr Gln Ala Asp Lys Leu Val Gln Arg Phe Asp Ala Gly Ser

260 265 270Tyr Val Leu Leu Thr Asp Ala Leu Asn Arg His Asp Ile Gly Arg Asp

275 280 285Arg Gly Gly Leu Asn Lys Ala Leu Glu Ser Ile Lys Val Pro Val Leu

290 295 300Val Ala Gly Val Asp Thr Asp Ile Leu Tyr Pro Tyr His Gln Gln Glu305 310 315 320His Leu Ser Arg Asn Leu Gly Asn Leu Leu Ala Met Ala Lys Ile Val

325 330 335Ser Pro Val Gly His Asp Ala Phe Leu Thr Glu Ser Arg Gln Met Asp

340 345 350Arg Ile Val Arg Asn Phe Phe Ser Leu Ile Ser Pro Asp Glu Asp Asn

355 360 365Pro Ser Thr Tyr Ile Glu Phe Tyr Ile

370375<210>189<211>1210<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1210)<223>FRXA00403<400>189tttttcagac tcgtgagaat gcaaactaga ctagacagag ctgtccatat acactggacg 60aagttttagt cttgtccacc cagaacaggc ggttattttc atg ccc acc ctc gcg 115

Met Pro Thr Leu Ala

1 5cct tca ggt caa ctt gaa atc caa gcg atc ggt gat gtc tcc acc gaa 163Pro Ser Gly Gln Leu Glu Ile Gln Ala Ile Gly Asp Val Ser Thr Glu

10 15 20gcc gga gca atc att aca aac gct gaa atc gcc tat cac cgc tgg ggt 211Ala Gly Ala Ile Ile Thr Asn Ala Glu Ile Ala Tyr His Arg Trp Gly

25 30 35gaa tac cgc gta gat aaa gaa gga cgc agc aat gtc gtt ctc atc gaa 259Glu Tyr Arg Val Asp Lys Glu Gly Arg Ser Asn Val Val Leu Ile Glu

40 45 50cac gcc ctc act gga gat tcc aac gca gcc gat tgg tgg gct gac ttg 307His Ala Leu Thr Gly Asp Ser Asn Ala Ala Asp Trp Trp Ala Asp Leu

55 60 65ctc ggt ccc ggc aaa gcc atc aac act gat att tac tgc gtg atc tgt 355Leu Gly Pro Gly Lys Ala Ile Asn Thr Asp Ile Tyr Cys Val Ile Cys 70 75 80 85acc aac gtc atc ggt ggt tgc aac ggt tcc acc gga cct ggc tcc atg 403Thr Asn Val Ile Gly Gly Cys Asn Gly Ser Thr Gly Pro Gly Ser Met

90 95 100cat cca gat gga aat ttc tgg ggt aat cgc ttc ccc gcc acg tcc att 451His Pro Asp Gly Asn Phe Trp Gly Asn Arg Phe Pro Ala Thr Ser Ile

105 110 115cgt gat cag gta aac gcc gaa aaa caa ttc ctc gac gca ctc ggc atc 499Arg Asp Gln Val Asn Ala Glu Lys Gln Phe Leu Asp Ala Leu Gly Ile

120 125 130acc acg gtc gcc gca gta ctt ggt ggt tcc atg ggt ggt gcc cgc acc 547Thr Thr Val Ala Ala Val Leu Gly Gly Ser Met Gly Gly Ala Arg Thr

135 140 145cta gag tgg gcc gca atg tac cca gaa act gtt ggc gca gct gct gtt 595Leu Glu Trp Ala Ala Met Tyr Pro Glu Thr Val Gly Ala Ala Ala Val150 155 160 165ctt gca gtt tct gca cgc gcc agc gcc tgg caa atc ggc att caa tcc 643Leu Ala Val Ser Ala Arg Ala Ser Ala Trp Gln Ile Gly Ile Gln Ser

170 175 180gcc caa att aag gcg att gaa aac gac cac cac tgg cac gaa ggc aac 691Ala Gln Ile Lys Ala Ile Glu Asn Asp His His Trp His Glu Gly Asn

185 190 195tac tac gaa tcc ggc tgc aac cca gcc acc gga ctc ggc gcc gcc cga 739Tyr Tyr Glu Ser Gly Cys Asn Pro Ala Thr Gly Leu Gly Ala Ala Arg

200 205 210cgc atc gcc cac ctc acc tac cgt ggc gaa cta gaa atc gac gaa cgc 787Arg Ile Ala His Leu Thr Tyr Arg Gly Glu Leu Glu Ile Asp Glu Arg

215 220 225ttc ggc acc aaa gcc caa aag aac gaa aac cca ctc ggt ccc tac cgc 835Phe Gly Thr Lys Ala Gln Lys Asn Glu Asn Pro Leu Gly Pro Tyr Arg230 235 240 245aag ccc gac cag cgc ttc gcc gtg gaa tcc tac ttg gac tac caa gca 883Lys Pro Asp Gln Arg Phe Ala Val Glu Ser Tyr Leu Asp Tyr Gln Ala

250 255 260gac aag cta gta cag cgt ttc gac gcc ggc tcc tac gtc ttg ctc acc 931Asp Lys Leu Val Gln Arg Phe Asp Ala Gly Ser Tyr Val Leu Leu Thr

265 270 275gac gcc ctc aac cgc cac gac att ggt cgc gac cgc gga ggc ctc aac 979Asp Ala Leu Asn Arg His Asp Ile Gly Arg Asp Arg Gly Gly Leu Asn

280 285 290aag gca ctc gaa tcc atc aaa gtt cca gtc ctt gtc gca ggc gta gat 1027Lys Ala Leu Glu Ser Ile Lys Val Pro Val Leu Val Ala Gly Val Asp

295 300 305acc gat att ttg tac ccc tac cac cag caa gaa cac ctc tcc aga aac 1075Thr Asp Ile Leu Tyr Pro Tyr His Gln Gln Glu His Leu Ser Arg Asn310 315 320 325ctg gga aat cta ctg gca atg gca aaa atc gta tcc cct gtc ggc cac 1123Leu Gly Asn Leu Leu Ala Met Ala Lys Ile Val Ser Pro Val Gly His

330 335 340gat gct ttc ctc acc gaa agc cgc caa atg gat cgc atc gtg agg aac 1171Asp Ala Phe Leu Thr Glu Ser Arg Gln Met Asp Arg Ile Val Arg Asn

345 350 355ttc ttc agc ctc atc tcc cca gac gaa gac aac cct tcg 1210Phe Phe Ser Leu Ile Ser Pro Asp Glu Asp Asn Pro Ser

360365370<210>190<211>370<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>190Met Pro Thr Leu Ala Pro Ser Gly Gln Leu Glu Ile Gln Ala Ile Gly 151015 Asp Val Ser Thr Glu Ala Gly Ala Ile Ile Thr Asn Ala Glu Ile Ala

20 25 30Tyr His Arg Trp Gly Glu Tyr Arg Val Asp Lys Glu Gly Arg Ser Asn

35 40 45Val Val Leu Ile Glu His Ala Leu Thr Gly Asp Ser Asn Ala Ala Asp

50 55 60Trp Trp Ala Asp Leu Leu Gly Pro Gly Lys Ala Ile Asn Thr Asp Ile 65 70 75 80Tyr Cys Val Ile Cys Thr Asn Val Ile Gly Gly Cys Asn Gly Ser Thr

85 90 95Gly Pro Gly Ser Met His Pro Asp Gly Asn Phe Trp Gly Asn Arg Phe

100 105 110Pro Ala Thr Ser Ile Arg Asp GlnVal Asn Ala Glu Lys Gln Phe Leu

115 120 125Asp Ala Leu Gly Ile Thr Thr Val Ala Ala Val Leu Gly Gly Ser Met

130 135 140Gly Gly Ala Arg Thr Leu Glu Trp Ala Ala Met Tyr Pro Glu Thr Val145 150 155 160Gly Ala Ala Ala Val Leu Ala Val Ser Ala Arg Ala Ser Ala Trp Gln

165 170 175Ile Gly Ile Gln Ser Ala Gln Ile Lys Ala Ile Glu Asn Asp His His

180 185 190Trp His Glu Gly Asn Tyr Tyr Glu Ser Gly Cys Asn Pro Ala Thr Gly

195 200 205Leu Gly Ala Ala Arg Arg Ile Ala His Leu Thr Tyr Arg Gly Glu Leu

210 215 220Glu Ile Asp Glu Arg Phe Gly Thr Lys Ala Gln Lys Asn Glu Asn Pro225 230 235 240Leu Gly Pro Tyr Arg Lys Pro Asp Gln Arg Phe Ala Val Glu Ser Tyr

245 250 255Leu Asp Tyr Gln Ala Asp Lys Leu Val Gln Arg Phe Asp Ala Gly Ser

260 265 270Tyr Val Leu Leu Thr Asp Ala Leu Asn Arg His Asp Ile Gly Arg Asp

275 280 285Arg Gly Gly Leu Asn Lys Ala Leu Glu Ser Ile Lys Val Pro Val Leu

290 295 300Val Ala Gly Val Asp Thr Asp Ile Leu Tyr Pro Tyr His Gln Gln Glu305 310 315 320His Leu Ser Arg Asn Leu Gly Asn Leu Leu Ala Met Ala Lys Ile Val

325 330 335Ser Pro Val Gly His Asp Ala Phe Leu Thr Glu Ser Arg Gln Met Asp

340 345 350Arg Ile Val Arg Asn Phe Phe Ser Leu Ile Ser Pro Asp Glu Asp Asn

355 360 365Pro Ser

370<210>191<211>687<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (664)<223>RXS03158<400>191caaagctcac cgaaggcacc aacgccaagt tggttgttga caacaccttg gcatccccat 60acctgcagca gccactaaaa ctcggcgcac acgcaagtcc ttg cac tcc acc acc 115

Leu His Ser Thr Thr

1 5aag tac atc gaa gga cac tcc gac gtt gtt ggc ggc ctt gtg ggt acc 163Lys Tyr Ile Glu Gly His Ser Asp Val Val Gly Gly Leu Val Gly Thr

10 15 20aac gac cag gaa atg gac gaa gaa ctg ctg ttc atg cag ggc ggc atc 211Asn Asp Gln Glu Met Asp Glu Glu Leu Leu Phe Met Gln Gly Gly Ile

25 30 35gga ccg atc cca tca gtt ttc gat gca tac ctg acc gcc cgt ggc ctc 259Gly Pro Ile Pro Ser Val Phe Asp Ala Tyr Leu Thr Ala Arg Gly Leu

40 45 50aag acc ctt gca gtg cgc atg gat cgc cac tgc gac aac gca gaa aag 307Lys Thr Leu Ala Val Arg Met Asp Arg His Cys Asp Asn Ala Glu Lys

55 60 65atc gcg gaa ttc ctg gac tcc cgc cca gag gtc tcc acc gtg ctc tac 355Ile Ala Glu Phe Leu Asp Ser Arg Pro Glu Val Ser Thr Val Leu Tyr 70 75 80 85cca ggt ctg aag aac cac cca ggc cac gaa gtc gca gcg aag cag atg 403Pro Gly Leu Lys Asn His Pro Gly His Glu Val Ala Ala Lys Gln Met

90 95 100aag cgc ttc ggc ggc atg atc tcc gtc cgt ttc gca ggc ggc gaa gaa 451Lys Arg Phe Gly Gly Met Ile Ser Val Arg Phe Ala Gly Gly Glu Glu

105 110 115gca gct aag aag ttc tgt acc tcc acc aaa ctg atc tgt ctg gcc gag 499Ala Ala Lys Lys Phe Cys Thr Ser Thr Lys Leu Ile Cys Leu Ala Glu

120 125 130tcc ctc ggt ggc gtg gaa tcc ctc ctg gag cac cca gca acc atg acc 547Ser Leu Gly Gly Val Glu Ser Leu Leu Glu His Pro Ala Thr Met Thr

135 140 145cac cag tca gct gcc ggc tct cag ctc gag gtt ccc cgc gac ctc gtg 595His Gln Ser Ala Ala Gly Ser Gln Leu Glu Val Pro Arg Asp Leu Val150 155 160 165cgc atc tcc att ggt att gaa gac att gaa gac ctg ctc gca gat gtc 643Arg Ile Ser Ile Gly Ile Glu Asp Ile Glu Asp Leu Leu Ala Asp Val

170 175 180gag cag gcc ctc aat aac ctt tagaaactat ttggcggcaa gca 687Glu Gln Ala Leu Asn Asn Leu

185<210>192<211>188<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>192Leu His Ser Thr Thr Lys Tyr Ile Glu Gly His Ser Asp Val Val Gly 151015 Gly Leu Val Gly Thr Asn Asp Gln Glu Met Asp Glu Glu Leu Leu Phe

20 25 30Met Gln Gly Gly Ile Gly Pro Ile Pro Ser Val Phe Asp Ala Tyr Leu

35 40 45Thr Ala Arg Gly Leu Lys Thr Leu Ala Val Arg Met Asp Arg His Cys

50 55 60Asp Asn Ala Glu Lys Ile Ala Glu Phe Leu Asp Ser Arg Pro Glu Val 65 70 7580Ser Thr Val Leu Tyr Pro Gly Leu Lys Asn His Pro Gly His Glu Val

85 90 95Ala Ala Lys Gln Met Lys Arg Phe Gly Gly Met Ile Ser Val Arg Phe

100 105 110Ala Gly Gly Glu Glu Ala Ala Lys Lys Phe Cys Thr Ser Thr Lys Leu

115 120 125Ile Cys Leu Ala Glu Ser Leu Gly Gly Val Glu Ser Leu Leu Glu His

130 135 140Pro Ala Thr Met Thr His Gln Ser Ala Ala Gly Ser Gln Leu Glu Val145 150 155 160Pro Arg Asp Leu Val Arg Ile Ser Ile Gly Ile Glu Asp Ile Glu Asp

165 170 175Leu Leu Ala Asp Val Glu Gln Ala Leu Asn Asn Leu

180185<210>193<211>617<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (594)<223>FRXA00254<400>193cag cca cta aaa ctc ggc gca cac gca gtc ttg cac tcc acc acc aag 48Gln Pro Leu Lys Leu Gly Ala His Ala Val Leu His Ser Thr Thr Lys 151015 tac atc gga gga cac tcc gac gtt gtt ggc ggc ctt gtg gtt acc aac 96Tyr Ile Gly Gly His Ser Asp Val Val Gly Gly Leu Val Val Thr Asn

20 25 30gac cag gaa atg gac gaa gaa ctg ctg ttc atg cag ggc ggc atc gga 144Asp Gln Glu Met Asp Glu Glu Leu Leu Phe Met Gln Gly Gly Ile Gly

35 40 45ccg atc cca tca gtt ttc gat gca tac ctg acc gcc cgt ggc ctc aag 192Pro Ile Pro Ser Val Phe Asp Ala Tyr Leu Thr Ala Arg Gly Leu Lys

50 55 60acc ctt gca gtg cgc atg gat cgc cac tgc gac aac gca gaa aag atc 240Thr Leu Ala Val Arg Met Asp Arg His Cys Asp Asn Ala Glu Lys Ile 65 70 75 80gcg gaa ttc ctg gac tcc cgc cca gag gtc tcc acc gtg ctc tac cca 288Ala Glu Phe Leu Asp Ser Arg Pro Glu Val Ser Thr Val Leu Tyr Pro

85 90 95ggt ctg aag aac cac cca ggc cac gaa gtc gca gcg aag cag atg aag 336Gly Leu Lys Asn His Pro Gly His Glu Val Ala Ala Lys Gln Met Lys

100 105 110cgc ttc ggc ggc atg atc tcc gtc cgt ttc gca ggc ggc gaa gaa gca 384Arg Phe Gly Gly Met Ile Ser Val Arg Phe Ala Gly Gly Glu Glu Ala

115 120 125gct aag aag ttc tgt acc tcc acc aaa ctg atc tgt ctg gcc gag tcc 432Ala Lys Lys Phe Cys Thr Ser Thr Lys Leu Ile Cys Leu Ala Glu Ser

130 135 140ctc ggt ggc gtg gaa tcc ctc ctg gag cac cca gca acc atg acc cac 480Leu Gly Gly Val Glu Ser Leu Leu Glu His Pro Ala Thr Met Thr His145 150 155 160cag tca gct gcc ggc tct cag ctc gag gtt ccc cgc gac ctc gtg cgc 528Gln Ser Ala Ala Gly Ser Gln Leu Glu Val Pro Arg Asp Leu Val Arg

165 170 175atc tcc att ggt att gaa gac att gaa gac ctg ctc gca gat gtc gag 576Ile Ser Ile Gly Ile Glu Asp Ile Glu Asp Leu Leu Ala Asp Val Glu

180 185 190cag gcc ctc aat aac ctt tagaaactat ttggcggcaa gca 617Gln Ala Leu Asn Asn Leu

195<210>194<211>198<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>194Gln Pro Leu Lys Leu Gly Ala His Ala Val Leu His Ser Thr Thr Lys 151015 Tyr Ile Gly Gly His Ser Asp Val Val Gly Gly Leu Val Val Thr Asn

20 25 30Asp Gln Glu Met Asp Glu Glu Leu Leu Phe Met Gln Gly Gly Ile Gly

35 40 45Pro Ile Pro Ser Val Phe Asp Ala Tyr Leu Thr Ala Arg Gly Leu Lys

50 55 60Thr Leu Ala Val Arg Met Asp Arg His Cys Asp Asn Ala Glu Lys Ile 65 70 75 80Ala Glu Phe Leu Asp Ser Arg Pro Glu Val Ser Thr Val Leu Tyr Pro

85 90 95Gly Leu Lys Asn His Pro Gly His Glu Val Ala Ala Lys Gln Met Lys

100 105 110Arg Phe Gly Gly Met Ile Ser Val Arg Phe Ala Gly Gly Glu Glu Ala

115 120 125Ala Lys Lys Phe Cys Thr Ser Thr Lys Leu Ile Cys Leu Ala Glu Ser

130 135 140Leu Gly Gly Val Glu Ser Leu Leu Glu His Pro Ala Thr Met Thr His145 150 155 160Gln Ser Ala Ala Gly Ser Gln Leu Glu Val Pro Arg Asp Leu Val Arg

165 170 175Ile Ser Ile Gly Ile Glu Asp Ile Glu Asp Leu Leu Ala Asp Val Glu

180 185 190Gln Ala Leu Asn Asn Leu

195<210>195<211>1170<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1147)<223>RXA02532<400>195gatgaatttt tacccaccat ctgtacctat taaccctgcg tggcgtccac ccacagtaac 60tgtgcaagcg ggacggccag ccagaactcc tggtgcgccg atg aac cca cct atc 115

Met Asn Pro Pro Ile

1 5acg ttg tcc agc act tat gtt cat gat tca gaa aaa gct tat ggg cgc 163Thr Leu Ser Ser Thr Tyr Val His Asp Ser Glu Lys Ala Tyr Gly Arg

10 15 20gat ggc aat gat gga tgg ggt gca ttt gag gct gcc atg gga act cta 211Asp Gly Asn Asp Gly Trp Gly Ala Phe Glu Ala Ala Met Gly Thr Leu

25 30 35gat ggt ggg ttc gcg gta tct tat tct tca ggt ttg gca gcg gca acg 259Asp Gly Gly Phe Ala Val Ser Tyr Ser Ser Gly Leu Ala Ala Ala Thr

40 45 50tcg att gct gat ttg gtt cct act ggt ggc aca gtt gtt tta cct aaa 307Ser Ile Ala Asp Leu Val Pro Thr Gly Gly Thr Val Val Leu Pro Lys

55 60 65gct gcc tat tat ggc gtg acc aat att ttc gcc agg atg gaa gcc cgc 355Ala Ala Tyr Tyr Gly Val Thr Asn Ile Phe Ala Arg Met Glu Ala Arg70 75 80 85gga agg ctg aag gtt cga act gtt gat gca gac aat acc gaa gaa gtg 403Gly Arg Leu Lys Val Arg Thr Val Asp Ala Asp Asn Thr Glu Glu Val

90 95 100att gct gct gct caa ggt gca gat gtg gtg tgg gtg gaa tcg atc gct 451Ile Ala Ala Ala Gln Gly Ala Asp Val Val Trp Val Glu Ser Ile Ala

105 110 115aat ccg acg atg gtg gta gct gat atc cct gca ata gtc gac ggt gtg 499Asn Pro Thr Met Val Val Ala Asp Ile Pro Ala Ile Val Asp Gly Val

120 125 130cgt ggg ctt gga gtt ttg act gtc gtt gac gcg act ttc gca acg cca 547Arg Gly Leu Gly Val Leu Thr Val Val Asp Ala Thr Phe Ala Thr Pro

135 140145ctt cgt caa cgt cca ttg gaa ctt ggt gct gat att gtg ctt tac tcg 595Leu Arg Gln Arg Pro Leu Glu Leu Gly Ala Asp Ile Val Leu Tyr Ser150 155 160 165gca acc aaa ctt atc ggt gga cac tct gat ctt ctt ctt gga gtc gca 643Ala Thr Lys Leu Ile Gly Gly His Ser Asp Leu Leu Leu Gly Val Ala

170 175 180gtg tgc aag tct gag cac cat gcg cag ttt ctt gcc act cac cgt cat 691Val Cys Lys Ser Glu His His Ala Gln Phe Leu Ala Thr His Arg His

185 190 195gat cat ggt tca gtg ccg gga ggt ctt gaa gcg ttt ctt gct ctc cgt 739Asp His Gly Ser Val Pro Gly Gly Leu Glu Ala Phe Leu Ala Leu Arg

200 205 210gga ttg tat tcc ttg gcg gtg cgt ctt gat cga gca gaa tcc aac gca 787Gly Leu Tyr Ser Leu Ala Val Arg Leu Asp Arg Ala Glu Ser Asn Ala

215 220 225gca gaa ctt tcg cgg cga ctt aac gcg cat cct tcg gtt acc cgc gtc 835Ala Glu Leu Ser Arg Arg Leu Asn Ala His Pro Ser Val Thr Arg Val230 235 240 245aat tat cca gga ctt cct gat gat ccc caa cat gaa aaa gcc gtg cga 883Asn Tyr Pro Gly Leu Pro Asp Asp Pro Gln His Glu Lys Ala Val Arg

250 255 260gtc cta ccc tct gga tgt gga aac atg ttg tca ttt gag ctt gat gca 931Val Leu Pro Ser Gly Cys Gly Asn Met Leu Ser Phe Glu Leu Asp Ala

265 270 275aca cct gaa cga act gat gag att ctc gaa agc ctg tca ctt tta acc 979Thr Pro Glu Arg Thr Asp Glu Ile Leu Glu Ser Leu Ser Leu Leu Thr

280 285 290cac gcg acc agt tgg gga ggt gtg gaa aca gcc att gaa cgt cgc acc 1027His Ala Thr Ser Trp Gly Gly Val Glu Thr Ala Ile Glu Arg Arg Thr

295 300 305agg cgg gat gct gaa gtg gtg gca gaa gta ccg atg act ctt tgc cgc 1075Arg Arg Asp Ala Glu Val Val Ala Glu Val Pro Met Thr Leu Cys Arg310 315 320 325gtt tcc gta gga att gaa gac gtt gaa gat cta tgg gaa gac ctc aac 1123Val Ser Val Gly Ile Glu Asp Val Glu Asp Leu Trp Glu Asp Leu Asn

330 335 340gcc tca atc gac aaa gtt ctg ggt tagaactcgt agccagtaac cag 1170Ala Ser Ile Asp Lys Val Leu Gly

345<210>196<211>349<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>196Met Asn Pro Pro Ile Thr Leu Ser Ser Thr Tyr Val His Asp Ser Glu 151015 Lys Ala Tyr Gly Arg Asp Gly Asn Asp Gly Trp Gly Ala Phe Glu Ala

20 25 30Ala Met Gly Thr Leu Asp Gly Gly Phe Ala Val Ser Tyr Ser Ser Gly

35 40 45Leu Ala Ala Ala Thr Ser Ile Ala Asp Leu Val Pro Thr Gly Gly Thr

50 55 60Val Val Leu Pro Lys Ala Ala Tyr Tyr Gly Val Thr Asn Ile Phe Ala 65 70 75 80Arg Met Glu Ala Arg Gly Arg Leu Lys Val Arg Thr Val Asp Ala Asp

85 90 95Asn Thr Glu Glu Val Ile Ala Ala Ala Gln Gly Ala Asp Val Val Trp

100 105 110Val Glu Ser Ile Ala Asn Pro Thr Met Val Val Ala Asp Ile Pro Ala

115 120 125Ile Val Asp Gly Val Arg Gly Leu Gly Val Leu Thr Val Val Asp Ala

130 135140Thr Phe Ala Thr Pro Leu Arg Gln Arg Pro Leu Glu Leu Gly Ala Asp145 150 155 160Ile Val Leu Tyr Ser Ala Thr Lys Leu Ile Gly Gly His Ser Asp Leu

165 170 175Leu Leu Gly Val Ala Val Cys Lys Ser Glu His His Ala Gln Phe Leu

180 185 190Ala Thr His Arg His Asp His Gly Ser Val Pro Gly Gly Leu Glu Ala

195 200 205Phe Leu Ala Leu Arg Gly Leu Tyr Ser Leu Ala Val Arg Leu Asp Arg

210 215 220Ala Glu Ser Asn Ala Ala Glu Leu Ser Arg Arg Leu Asn Ala His Pro225 230 235 240Ser Val Thr Arg Val Asn Tyr Pro Gly Leu Pro Asp Asp Pro Gln His

245 250 255Glu Lys Ala Val Arg Val Leu Pro Ser Gly Cys Gly Asn Met Leu Ser

260 265 270Phe Glu Leu Asp Ala Thr Pro Glu Arg Thr Asp Glu Ile Leu Glu Ser

275 280 285Leu Ser Leu Leu Thr His Ala Thr Ser Trp Gly Gly Val Glu Thr Ala

290 295 300Ile Glu Arg Arg Thr Arg Arg Asp Ala Glu Val Val Ala Glu Val Pro305 310 315 320Met Thr Leu Cys Arg Val Ser Val Gly Ile Glu Asp Val Glu Asp Leu

325 330 335Trp Glu Asp Leu Asn Ala Ser Ile Asp Lys Val Leu Gly

340345<210>197<211>861<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (838)<223>RXS03159<400>197aggggctagt tttacacaaa agtggacagc ttggtctatc attgccagaa gaccggtcct 60tttagggcca tagaattctg attacaggag ttgatctacc ttg tct ttt gac cca 115

Leu Ser Phe Asp Pro

1 5aac acc cag ggt ttc tcc act gca tcg att cac gct ggg tat gag cca 163Asn Thr Gln Gly Phe Ser Thr Ala Ser Ile His Ala Gly Tyr Glu Pro

10 15 20gac gac tac tac ggt tcg att aac acc cca atc tat gcc tcc acc acc 211Asp Asp Tyr Tyr Gly Ser Ile Asn Thr Pro Ile Tyr Ala Ser Thr Thr

25 30 35ttc gcg cag aac gct cca aac gaa ctg cgc aaa ggc tac gag tac acc 259Phe Ala Gln Asn Ala Pro Asn Glu Leu Arg Lys Gly Tyr Glu Tyr Thr

40 45 50cgt gtg ggc aac ccc acc atc gtg gca tta gag cag acc gtc gca gca 307Arg Val Gly Asn Pro Thr Ile Val Ala Leu Glu Gln Thr Val Ala Ala

55 60 65ctc gaa ggc gca aag tat ggc cgc gca ttc tcc tcc ggc atg gct gca 355Leu Glu Gly Ala Lys Tyr Gly Arg Ala Phe Ser Ser Gly Met Ala Ala 70 75 80 85acc gac atc ctg ttc cgc atc atc ctc aag ccg ggc gat cac atc gtc 403Thr Asp Ile Leu Phe Arg Ile Ile Leu Lys Pro Gly Asp His Ile Val

90 95 100ctc ggc aac gat gct tac ggc gga acc tac cgc ctg atc gac acc gta 451Leu Gly Asn Asp Ala Tyr Gly Gly Thr Tyr Arg Leu Ile Asp Thr Val

105 110 115ttc acc gca tgg ggc gtc gaa tac acc gtt gtt gat acc tcc gtc gtg 499Phe Thr Ala Trp Gly Val Glu Tyr Thr Val Val Asp Thr Ser Val Val

120125 130gaa gag gtc aag gca gcg atc aag gac aac acc aag ctg atc tgg gtg 547Glu Glu Val Lys Ala Ala Ile Lys Asp Asn Thr Lys Leu Ile Trp Val

135 140 145gaa acc cca acc aac cca gca ctt ggc atc acc gac atc gaa gca gta 595Glu Thr Pro Thr Asn Pro Ala Leu Gly Ile Thr Asp Ile Glu Ala Val150 155 160 165gca aag ctc acc gaa ggc acc aac gcc aag ttg gtt gtt gac aac acc 643Ala Lys Leu Thr Glu Gly Thr Asn Ala Lys Leu Val Val Asp Asn Thr

170 175 180ttg gca tcc cca tac ctg cag cag cca cta aaa ctc ggc gca cac gca 691Leu Ala Ser Pro Tyr Leu Gln Gln Pro Leu Lys Leu Gly Ala His Ala

185 190 195agt cct tgc act cca cca cca agt aca tcg aag gac act ccg acg ttg 739Ser Pro Cys Thr Pro Pro Pro Ser Thr Ser Lys Asp Thr Pro Thr Leu

200 205 210ttg gcg gcc ttg tgg gta cca acg acc agg aaa tgg acg aag aac tgc 787Leu Ala Ala Leu Trp Val Pro Thr Thr Arg Lys Trp Thr Lys Asn Cys

215220225 tgt tca tgc agg gcg gca tcg gac cga tcc cat cag ttt tcg atg cat 835Cys Ser Cys Arg Ala Ala Ser Asp Arg Ser His Gln Phe Ser Met His 230235240245 acc tgaccgcccg tggcctcaag acc 861Thr<210>198<211>246<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>198Leu Ser Phe Asp Pro Asn Thr Gln Gly Phe Ser Thr Ala Ser Ile His 151015 Ala Gly Tyr Glu Pro Asp Asp Tyr Tyr Gly Ser Ile Asn Thr Pro Ile

20 25 30Tyr Ala Ser Thr Thr Phe Ala Gln Asn Ala Pro Asn Glu Leu Arg Lys

35 40 45Gly Tyr Glu Tyr Thr Arg Val Gly Asn Pro Thr Ile Val Ala Leu Glu

50 55 60Gln Thr Val Ala Ala Leu Glu Gly Ala Lys Tyr Gly Arg Ala Phe Ser 65 70 75 80Ser Gly Met Ala Ala Thr Asp Ile Leu Phe Arg Ile Ile Leu Lys Pro

85 90 95Gly Asp His Ile Val Leu Gly Asn Asp Ala Tyr Gly Gly Thr Tyr Arg

100 105 1l0Leu Ile Asp Thr Val Phe Thr Ala Trp Gly Val Glu Tyr Thr Val Val

115 120 125Asp Thr Ser Val Val Glu Glu Val Lys Ala Ala Ile Lys Asp Asn Thr

130 135 140Lys Leu Ile Trp Val Glu Thr Pro Thr Asn Pro Ala Leu Gly Ile Thr145 150 155 160Asp Ile Glu Ala Val Ala Lys Leu Thr Glu Gly Thr Asn Ala Lys Leu

165 170 175Val Val Asp Asn Thr Leu Ala Ser Pro Tyr Leu Gln Gln Pro Leu Lys

180 185 190Leu Gly Ala His Ala Ser Pro Cys Thr Pro Pro Pro Ser Thr Ser Lys

195 200 205Asp Thr Pro Thr Leu Leu Ala Ala Leu Trp Val Pro Thr Thr Arg Lys

210 215 220Trp Thr Lys Asn Cys Cys Ser Cys Arg Ala Ala Ser Asp Arg Ser His225 230 235 240Gln Phe Ser Met His Thr

245<210>199<211>703<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (703)<223>FRXA02768<220><221>misc feature<222>676, 687, 690, 691, 693<223>n ═ a, c, g, or t<220><221>VARIANT<222>192<223>Xaa ═ His or Gln<220><221>VARIANT<222>196>Xaa ═ Ile, Thr, Asn, or Ser<220><221>VARIANT<222>197<223>Xaa ═ Phe, Leu, Ser, Tyr, Cys, 223>Trp, or STOP CODON<220>221>VARIAT<222>Xaa<115>Xaa<8584>Gly<85115, Ala<8584>Gly<85223>Gly<115>Glu>199, Val<8560>Gly<85115>Gly<aggggctagt tttacacaaa agtggacagc ttggtctatc attgccagaa gaccggtcct, Gly<aggggctagt tttacacaaa agtggacagc ttggtctatc attgccagaa gaccggtcct>Gly<85115>Glu

Leu Ser Phe Asp Pro

1 5aac acc cag ggt ttc tcc act gca tog att cac gct ggg tat gag cca 163Asn Thr Gln Gly Phe Ser Thr Ala Ser Ile His Ala Gly Tyr Glu Pro

10 15 20gac gac tac tac ggt tcg att aac acc cca atc tat gcc tcc acc acc 211Asp Asp Tyr Tyr Gly Ser Ile Asn Thr Pro Ile Tyr Ala Ser Thr Thr

25 30 35ttc gcg cag aac gct cca aac gaa ctg cgc aaa ggc tac gag tac acc 259Phe Ala Gln Asn Ala Pro Asn Glu Leu Arg Lys Gly Tyr Glu Tyr Thr

40 45 50cgt gtg ggc aac ccc acc atc gtg gca tta gag cag acc gtc gca gca 307Arg Val Gly Asn Pro Thr Ile Val Ala Leu Glu Gln Thr Val Ala Ala

55 60 65crc gaa ggc gca aag tat ggc cgc gca ttc tcc tcc ggc atg gct gca 355Leu Glu Gly Ala Lys Tyr Gly Arg Ala Phe Ser Ser Gly Met Ala Ala 70 75 80 85acc gac atc ctg ttc cgc atc atc ctc aag ccg ggc gat cac atc gtc 403Thr Asp Ile Leu Phe Arg Ile Ile Leu Lys Pro Gly Asp His Ile Val

90 95 100ctc ggc aac gat gct tac ggc gga acc tac cgc ctg atc gac acc gta 451Leu Gly Asn Asp Ala Tyr Gly Gly Thr Tyr Arg Leu Ile Asp Thr Val

105 110 115ttc acc gca tgg ggc gtc gaa tac acc gtt gtt gat acc tcc gtc gtg 499Phe Thr Ala Trp Gly Val Glu Tyr Thr Val Val Asp Thr Ser Val Val

120 125 130gaa gag gtc aag gca gcg atc aag gac aac acc aag gct gat ctt ggt 547Glu Glu Val Lys Ala Ala Ile Lys Asp Asn Thr Lys Ala Asp Leu Gly

135 140 145gga aac ccc aac caa ccc agc act ttg gca tta ccc gac atc gaa gca 595Gly Asn Pro Asn Gln Pro Ser Thr Leu Ala Leu Pro Asp Ile Glu Ala150 155 160 165gtn tgc aaa act tca ccc gaa agg cac caa ccc caa gct tgt tgt ttg 643Val Cys Lys Thr Ser Pro Glu Arg His Gln Pro Gln Ala Cys Cys Leu

170 175 180aca aca cct tcg cat tcc cca tac ctg cag can cca ctt aaa ant tnn 691Thr Thr Pro Ser His Ser Pro Tyr Leu Gln Xaa Pro Leu Lys Xaa Xaa

185 190 195gng cac acg cag 703Xaa His Thr Gln

200<210>200<211>201<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>VARIANT<222>192<223>Xaa ═ His or Gln<220><221>VARIANT<222>196<223>Xaa ═ Ile, Thr, Asn, or Ser<220><221>VARIANT<222>197<223>Xaa ═ Phe, Leu, Ser, Tyr, Cys,<223>Trp, or STOP CODON<220><221>VARIANT<222>198<223>Xaa ═ Val, Ala, Glu, or Gly<400>200Leu Ser Phe Asp Pro Asn Thr Gln Gly Phe Ser Thr Ala Ser Ile His 151015 151 151015 Ala Gly Tyr Glu Pro Asp Asp Tyr Tyr Gly Ser Ile Asn Thr Pro Ile Val 015

20 25 30Tyr Ala Ser Thr Thr Phe Ala Gln Asn Ala Pro Asn Glu Leu Arg Lys

35 40 45Gly Tyr Glu Tyr Thr Arg Val Gly Asn Pro Thr Ile Val Ala Leu Glu

50 55 60Gln Thr Val Ala Ala Leu Glu Gly Ala Lys Tyr Gly Arg Ala Phe Ser 65 70 75 80Ser Gly Met Ala Ala Thr Asp Ile Leu Phe Arg Ile Ile Leu Lys Pro

85 90 95Gly Asp His Ile Val Leu Gly Asn Asp Ala Tyr Gly Gly Thr Tyr Arg

100 105 110Leu Ile Asp Thr Val Phe Thr Ala Trp Gly Val Glu Tyr Thr Val Val

115 120 125Asp Thr Ser Val Val Glu Glu Val Lys Ala Ala Ile Lys Asp Asn Thr

130 135 140Lys Ala Asp Leu Gly Gly Asn Pro Asn Gln Pro Ser Thr Leu Ala Leu145 150 155 160Pro Asp Ile Glu Ala Val Cys Lys Thr Ser Pro Glu Arg His Gln Pro

165 170 175Gln Ala Cys Cys Leu Thr Thr Pro Ser His Ser Pro Tyr Leu Gln Xaa

180 185 190Pro Leu Lys Xaa Xaa Xaa His Thr Gln

195200<210>201<211>1113<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1090)<223>RXA00216<400>201gtgttgctcg cggccaggca gcagtgctgt acctgcctga cgcggatggt gacatcgttc 60ttggatcagg caccatctgc cacacggagt cttaagaaaa ttg ggc gct tat ggt 115

Leu Gly Ala Tyr Gly

1 5tta ggt gag ctt cct gga aaa tcc gcc gcg gaa gcc gcc gac att att 163Leu Gly Glu Leu Pro Gly Lys Ser Ala Ala Glu Ala Ala Asp Ile Ile

10 15 20cag ggt gaa acg ggc gat ctt ctc cat att cct cag ctt ccg gcg cga 211Gln Gly Glu Thr Gly Asp Leu Leu His Ile Pro Gln Leu Pro Ala Arg

25 30 35ggt ttg ggt gct gat ctg atc ggt cga acc gtc ggt ctg ctg gac atg 259Gly Leu Gly Ala Asp Leu Ile Gly Arg Thr Val Gly Leu Leu Asp Met

40 45 50atc aac gtt gat cgc ggg gcc cga tct tgg gtg atg agc aca cgc ccc 307Ile Asn Val Asp Arg Gly Ala Arg Ser Trp Val Met Ser Thr Arg Pro

55 60 65agc aga ttg acg cac ctg acc ggc gat ttc ctt gac atg gat ttg gat 355Ser Arg Leu Thr His Leu Thr Gly Asp Phe Leu Asp Met Asp Leu Asp 70 75 80 85gcg tgc gag gaa acc tgg gga acg ggc gtc gac aag cta aaa atc caa 403Ala Cys Glu Glu Thr Trp Gly Thr Gly Val Asp Lys Leu Lys Ile Gln

90 95 100gtt gct ggt ccc tgg act tta ggt gcg cgc att gag ttg gcc aat ggc 451Val Ala Gly Pro Trp Thr Leu Gly Ala Arg Ile Glu Leu Ala Asn Gly

105 110 115cat cgc gtt ttg tct gat cgc ggt gcg atg cgt gat ctc acg cag gcg 499His Arg Val Leu Ser Asp Arg Gly Ala Met Arg Asp Leu Thr Gln Ala

120 125 130ctg atc gcc ggc atc gat gcg cat gca cgc aag gtt gct ggg cga ttt 547Leu Ile Ala Gly Ile Asp Ala His Ala Arg Lys Val Ala Gly Arg Phe

135 140 145cgc gcc gaa gtg cag gtg caa att gat gag ccg gag ctg aaa tcg ctt 595Arg Ala Glu Val Gln Val Gln Ile Asp Glu Pro Glu Leu Lys Ser Leu150 155 160 165atc gac ggc tcc ctc cct ggc act tcc acc ttt gac att att cct gcg 643Ile Asp Gly Ser Leu Pro Gly Thr Ser Thr Phe Asp Ile Ile Pro Ala

170 175 180gtg aat gtc gct gat gcc agt gaa cgt ttg cag cag gtc ttt agc tcg 691Val Asn Val Ala Asp Ala Ser Glu Arg Leu Gln Gln Val Phe Ser Ser

185 190 195att gag ggg ccg aca tat ctc aac ctc acc ggc cag att cct act tgg 739Ile Glu Gly Pro Thr Tyr Leu Asn Leu Thr Gly Gln Ile Pro Thr Trp

200 205 210gat gtg gct cgg ggt gcg ggc gcc gat act gtg cag att tcc atg gat 787Asp Val Ala Arg Gly Ala Gly Ala Asp Thr Val Gln Ile Ser Met Asp

215 220 225caa gtc cgt gga aat gaa cat ttg gat ggt ttt ggt gaa acc atc acc 835Gln Val Arg Gly Asn Glu His Leu Asp Gly Phe Gly Glu Thr Ile Thr230 235 240 245agt gga att cgt ctt ggt ttg ggc att acg aca gga aaa gat gtc gta 883Ser Gly Ile Arg Leu Gly Leu Gly Ile Thr Thr Gly Lys Asp Val Val

250 255 260gat gaa ctg ctc gag cga ccg cgg caa aag gcc gtt gag gta gca cgc 931Asp Glu Leu Leu Glu Arg Pro Arg Gln Lys Ala Val Glu Val Ala Arg

265 270 275ttt ttt gat cgt tta ggt gtg ggc cga aac tat ctc gtg gat gct gtt 979Phe Phe Asp Arg Leu Gly Val Gly Arg Asn Tyr Leu Val Asp Ala Val

280285 290gat att cat ccg ggt gag gat ttg gtg cag ggg acc atc acc gag gcc 1027Asp Ile His Pro Gly Glu Asp Leu Val Gln Gly Thr Ile Thr Glu Ala

295 300 305gcg cag gct tat cgc atg gcc cgg gtg atg tcg gag atg ttg tcg aag 1075Ala Gln Ala Tyr Arg Met Ala Arg Val Met Ser Glu Met Leu Ser Lys310 315 320 325gat tca tgc gac ctt taaggcttta ccggcgctgg gtg 1113Asp Ser Cys Asp Leu

330<210>202<211>330<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>202Leu Gly Ala Tyr Gly Leu Gly Glu Leu Pro Gly Lys Ser Ala Ala Glu 151015 Ala Ala Asp Ile Ile Gln Gly Glu Thr Gly Asp Leu Leu His Ile Pro

20 25 30Gln Leu Pro Ala Arg Gly Leu Gly Ala Asp Leu Ile Gly Arg Thr Val

35 40 45Gly Leu Leu Asp Met Ile Asn Val Asp Arg Gly Ala Arg Ser Trp Val

50 55 60Met Ser Thr Arg Pro Ser Arg Leu Thr His Leu Thr Gly Asp Phe Leu 65 70 75 80Asp Met Asp Leu Asp Ala Cys Glu Glu Thr Trp Gly Thr Gly Val Asp

85 90 95Lys Leu Lys Ile Gln Val Ala Gly Pro Trp Thr Leu Gly Ala Arg Ile

100 105 110Glu Leu Ala Asn Gly His Arg Val Leu Ser Asp Arg Gly Ala Met Arg

115 120 125Asp Leu Thr Gln Ala Leu Ile Ala Gly Ile Asp Ala His Ala Arg Lys

130 135 140Val Ala Gly Arg Phe Arg Ala Glu Val Gln Val Gln Ile Asp Glu Pro145 150 155160Glu Leu Lys Ser Leu Ile Asp Gly Ser Leu Pro Gly Thr Ser Thr Phe

165 170 175Asp Ile Ile Pro Ala Val Asn Val Ala Asp Ala Ser Glu Arg Leu Gln

180 185 190Gln Val Phe Ser Ser Ile Glu Gly Pro Thr Tyr Leu Asn Leu Thr Gly

195 200 205Gln Ile Pro Thr Trp Asp Val Ala Arg Gly Ala Gly Ala Asp Thr Val

210 215 220Gln Ile Ser Met Asp Gln Val Arg Gly Asn Glu His Leu Asp Gly Phe225 230 235 240Gly Glu Thr Ile Thr Ser Gly Ile Arg Leu Gly Leu Gly Ile Thr Thr

245 250 255Gly Lys Asp Val Val Asp Glu Leu Leu Glu Arg Pro Arg Gln Lys Ala

260 265 270Val Glu Val Ala Arg Phe Phe Asp Arg Leu Gly Val Gly Arg Asn Tyr

275 280 285Leu Val Asp Ala Val Asp Ile His Pro Gly Glu Asp Leu Val Gln Gly

290 295 300Thr Ile Thr Glu Ala Ala Gln Ala Tyr Arg Met Ala Arg Val Met Ser305 310 315 320Glu Met Leu Ser Lys Asp Ser Cys Asp Leu

325330<210>203<211>623<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (600)<223>RXN00402<400>203act gac gaa aag gat gga aag cca gta ttg ccc tac ttc gtc act cca 48Thr Asp Glu Lys Asp Gly Lys Pro Val Leu Pro Tyr Phe Val Thr Pro 151015 gat gct gct tac cac gga ttg aag tac gca gac ctt ggt gca cca gcc 96Asp Ala Ala Tyr His Gly Leu Lys Tyr Ala Asp Leu Gly Ala Pro Ala

20 25 30ttc ggc ctc aag gtt cgc gtt ggc ctt cta cgc gac acc ggc tcc acc 144Phe Gly Leu Lys Val Arg Val Gly Leu Leu Arg Asp Thr Gly Ser Thr

35 40 45ctc tcc gca ttc aac gca tgg gct gca gtc cag ggc atc gac acc ctt 192Leu Ser Ala Phe Asn Ala Trp Ala Ala Val Gln Gly Ile Asp Thr Leu

50 55 60tcc ctg cgc ctg gag cgc cac aac gaa aac gcc atc aag gtt gca gaa 240Ser Leu Arg Leu Glu Arg His Asn Glu Asn Ala Ile Lys Val Ala Glu 65 70 75 80ttc ctc aac aac cac gag aag gtg gaa aag gtt aac ttc gca ggc ctg 288Phe Leu Asn Asn His Glu Lys Val Glu Lys Val Asn Phe Ala Gly Leu

85 90 95aag gat tcc cct tgg tac gca acc aag gaa aag ctt ggc ctg aag tac 336Lys Asp Ser Pro Trp Tyr Ala Thr Lys Glu Lys Leu Gly Leu Lys Tyr

100 105 110acc ggc tcc gtt ctc acc ttc gag atc aag ggc ggc aag gat gag gct 384Thr Gly Ser Val Leu Thr Phe Glu Ile Lys Gly Gly Lys Asp Glu Ala

115 120 125tgg gca ttt atc gac gcc ctg aag cta cac tcc aac ctt gca aac atc 432Trp Ala Phe Ile Asp Ala Leu Lys Leu His Ser Asn Leu Ala Asn Ile

130 135 140ggc gat gtt cgc tcc ctc gtt gtt cac cca gca acc acc acc cat tca 480Gly Asp Val Arg Ser Leu Val Val His Pro Ala Thr Thr Thr His Ser145 150 155 160cag tcc gac gaa gct ggc ctg gca cgc gcg ggc gtt acc cag tcc acc 528Gln Ser Asp Glu Ala Gly Leu Ala Arg Ala Gly Val Thr Gln Ser Thr

165 170 175gtc cgc ctg tcc gtt ggc atc gag acc att gat gat atcatc gct gac 576Val Arg Leu Ser Val Gly Ile Glu Thr Ile Asp Asp Ile Ile Ala Asp

180 185 190ctc gaa ggc ggc ttt gct gca atc tagctttaaa tagactcacc cca 623Leu Glu Gly Gly Phe Ala Ala Ile

195200<210>204<211>200<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>204Thr Asp Glu Lys Asp Gly Lys Pro Val Leu Pro Tyr Phe Val Thr Pro 151015 Asp Ala Ala Tyr His Gly Leu Lys Tyr Ala Asp Leu Gly Ala Pro Ala

20 25 30Phe Gly Leu Lys Val Arg Val Gly Leu Leu Arg Asp Thr Gly Ser Thr

35 40 45Leu Ser Ala Phe Asn Ala Trp Ala Ala Val Gln Gly Ile Asp Thr Leu

50 55 60Ser Leu Arg Leu Glu Arg His Asn Glu Asn Ala Ile Lys Val Ala Glu 65 70 75 80Phe Leu Asn Asn His Glu Lys Val Glu Lys Val Asn Phe Ala Gly Leu

85 90 95Lys Asp Ser Pro Trp Tyr Ala Thr Lys Glu Lys Leu Gly Leu Lys Tyr

100 105 110Thr Gly Ser Val Leu Thr Phe Glu Ile Lys Gly Gly Lys Asp Glu Ala

115 120 125Trp Ala Phe Ile Asp Ala Leu Lys Leu His Ser Asn Leu Ala Asn Ile

130 135 140Gly Asp Val Arg Ser Leu Val Val His Pro Ala Thr Thr Thr His Ser145 150 155 160Gln Ser Asp Glu Ala Gly Leu Ala Arg Ala Gly Val Thr Gln Ser Thr

165 170 175Val Arg Leu Ser Val Gly Ile Glu Thr Ile Asp Asp Ile Ile Ala Asp

180 185 190Leu Glu Gly Gly Phe Ala Ala Ile

195200<2l0>205<211>599<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220>CDS<222>(1). (576)<223>FRXA00402<400>205gta ttg ccc tac ttc gtc act cca gat gct gct tac cac gga ttg aag 48Val Leu Pro Tyr Phe Val Thr Pro Asp Ala Ala Tyr His Gly Leu Lys 151015 tac gca gac ctt ggt gca cca gcc ttc ggc ctc aag gtt cgc gtt ggc 96Tyr Ala Asp Leu Gly Ala Pro Ala Phe Gly Leu Lys Val Arg Val Gly

20 25 30ctt cta cgc gac acc ggc tcc acc ctc tcc gca ttc aac gca tgg gct 144Leu Leu Arg Asp Thr Gly Ser Thr Leu Ser Ala Phe Asn Ala Trp Ala

35 40 45gca gtc cag ggc atc gac acc ctt tcc ctg cgc ctg gag cgc cac aac 192Ala Val Gln Gly Ile Asp Thr Leu Ser Leu Arg Leu Glu Arg His Asn

50 55 60gaa aac gcc atc aag gtt gca gaa ttc ctc aac aac cac gag aag gtg 240Glu Asn Ala Ile Lys Val Ala Glu Phe Leu Asn Asn His Glu Lys Val 65 70 75 80gaa aag gtt aac ttc gca ggc ctg aag gat tcc cct tgg tac gca acc 288Glu Lys Val Asn Phe Ala Gly Leu Lys Asp Ser Pro Trp Tyr Ala Thr

85 90 95aag gaa aag ctt ggc ctg aag tac acc ggc tcc gtt ctc acc ttc gag 336Lys Glu Lys Leu Gly Leu Lys Tyr Thr Gly Ser Val Leu Thr Phe Glu

100 105 110atc aag ggc ggc aag gat gag gct tgg gca ttt atc gac gcc ctg aag 384Ile Lys Gly Gly Lys Asp Glu Ala Trp Ala Phe Ile Asp Ala Leu Lys

115 120 125cta cac tcc aac ctt gca aac atc ggc gat gtt cgc tcc ctc gttgtt 432Leu His Ser Asn Leu Ala Asn Ile Gly Asp Val Arg Ser Leu Val Val

130 135 140cac cca gca acc acc acc cat tca cag tcc gac gaa gct ggc ctg gca 480His Pro Ala Thr Thr Thr His Ser Gln Ser Asp Glu Ala Gly Leu Ala145 150 155 160cgc gcg ggc gtt acc cag tcc acc gtc cgc ctg tcc gtt ggc atc gag 528Arg Ala Gly Val Thr Gln Ser Thr Val Arg Leu Ser Val Gly Ile Glu

165 170 175acc att gat gat atc atc gct gac ctc gaa ggc ggc ttt gct gca atc 576Thr Ile Asp Asp Ile Ile Ala Asp Leu Glu Gly Gly Phe Ala Ala Ile

180185190 tagctttaaa tagactcacc cca 599<210>206<211>192<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>206Val Leu Pro Tyr Phe Val Thr Pro Asp Ala Ala Tyr His Gly Leu Lys 151015 Tyr Ala Asp Leu Gly Ala Pro Ala Phe Gly Leu Lys Val Arg Val Gly

20 25 30Leu Leu Arg Asp Thr Gly Ser Thr Leu Ser Ala Phe Asn Ala Trp Ala

35 40 45Ala Val Gln Gly Ile Asp Thr Leu Ser Leu Arg Leu Glu Arg His Asn

50 55 60Glu Asn Ala Ile Lys Val Ala Glu Phe Leu Asn ASn His Glu Lys Val 65 70 75 80Glu Lys Val Asn Phe Ala Gly Leu Lys Asp Ser Pro Trp Tyr Ala Thr

85 90 95Lys Glu Lys Leu Gly Leu Lys Tyr Thr Gly Ser Val Leu Thr Phe Glu

100 105 110Ile Lys Gly Gly Lys Asp Glu Ala Trp Ala Phe Ile Asp Ala Leu Lys

115 120 125Leu His Ser Asn Leu Ala Asn Ile GlyAsp Val Arg Ser Leu Val Val

130 135 140His Pro Ala Thr Thr Thr His Ser Gln Ser Asp Glu Ala Gly Leu Ala145 150 155 160Arg Ala Gly Val Thr Gln Ser Thr Val Arg Leu Ser Val Gly Ile Glu

165 170 175Thr Ile Asp Asp Ile Ile Ala Asp Leu Glu Gly Gly Phe Ala Ala Ile

180185190<210>207<211>613<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (613)<223>RXA00405<400>207agaataaatt tataccacac agtctattgc aatagaccaa gctgttcagt agggtgcatg 60ggagaagaat ttcctaataa aaactcttaa ggacctccaa atg cca aag tac gac 115

Met Pro Lys Tyr Asp

1 5aat tcc aat gct gac cag tgg ggc ttt gaa acc cgc tcc att cac gca 163Asn Ser Asn Ala Asp Gln Trp Gly Phe Glu Thr Arg Ser Ile His Ala

10 15 20ggc cag tca gta gac gca cag acc agc gca cga aac ctt ccg atc tac 211Gly Gln Ser Val Asp Ala Gln Thr Ser Ala Arg Asn Leu Pro Ile Tyr

25 30 35caa tcc acc gct ttc gtg ttc gac tcc gct gag cac gcc aag cag cgt 259Gln Ser Thr Ala Phe Val Phe Asp Ser Ala Glu His Ala Lys Gln Arg

40 45 50ttc gca ctt gag gat eta ggc cct gtt tac tcc cgc ctc acc aac cca 307Phe Ala Leu Glu Asp Leu Gly Pro Val Tyr Ser Arg Leu Thr Asn Pro

55 60 65acc gtt gag gct ttg gaa aac cgc atc gct tcc ctc gaa ggt ggc gtc 355Thr Val Glu Ala Leu Glu Asn Arg Ile Ala Ser Leu Glu Gly Gly Val 7075 80 85cac gct gta gcg ttc tcc tcc gga cag gcc gca acc acc aac gcc att 403His Ala Val Ala Phe Ser Ser Gly Gln Ala Ala Thr Thr Asn Ala Ile

90 95 100ttg aac ctg gca gga gcg ggc gac cac atc gtc acc tcc cca cgc ctc 451Leu Asn Leu Ala Gly Ala Gly Asp His Ile Val Thr Ser Pro Arg Leu

105 110 115tac ggt ggc acc gag act cta ttc ctt atc act ctt aac cgc ctg ggt 499Tyr Gly Gly Thr Glu Thr Leu Phe Leu Ile Thr Leu Asn Arg Leu Gly

120 125 130atc gat gtt tcc ttc gtg gaa aac ccc gac gac cct gag tcc tgg cag 547Ile Asp Val Ser Phe Val Glu Asn Pro Asp Asp Pro Glu Ser Trp Gln

135 140 145gca gcc gtt cag cca aac acc aaa gca ttc ttc ggc gag act ttc gcc 595Ala Ala Val Gln Pro Asn Thr Lys Ala Phe Phe Gly Glu Thr Phe Ala150 155 160 165aac cca cag gca gac gtc 613Asn Pro Gln Ala Asp Val

170<210>208<211>171<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>208Met Pro Lys Tyr Asp Asn Ser Asn Ala Asp Gln Trp Gly Phe Glu Thr 151015 Arg Ser Ile His Ala Gly Gln Ser Val Asp Ala Gln Thr Ser Ala Arg

20 25 30Asn Leu Pro Ile Tyr Gln Ser Thr Ala Phe Val Phe Asp Ser Ala Glu

35 40 45His Ala Lys Gln Arg Phe Ala Leu Glu Asp Leu Gly Pro Val Tyr Ser

50 55 60Arg Leu Thr Asn Pro Thr Val Glu Ala Leu Glu Asn Arg Ile Ala Ser 65 70 75 80Leu Glu Gly Gly Val His Ala Val Ala Phe Ser Ser Gly Gln Ala Ala

85 90 95Thr Thr Asn Ala Ile Leu Asn Leu Ala Gly Ala Gly Asp His Ile Val

100 105 110Thr Ser Pro Arg Leu Tyr Gly Gly Thr Glu Thr Leu Phe Leu Ile Thr

115 120 125Leu Asn Arg Leu Gly Ile Asp Val Ser Phe Val Glu Asn Pro Asp Asp

130 135 140Pro Glu Ser Trp Gln Ala Ala Val Gln Pro Asn Thr Lys Ala Phe Phe145 150 155 160Gly Glu Thr Phe Ala Asn Pro Gln Ala Asp Val

165170<210>209<211>551<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) } (528)<223>RXA02197<400>209gcc gaa cgc atg cgc ttt agc ttc cca cgc cag cag cgc ggc agg ttc 48Ala Glu Arg Met Arg Phe Ser Phe Pro Arg Gln Gln Arg Gly Arg Phe 151015 ttg tgc atc gcg gat ttc att cgc cca cgc gag caa gct gtc aag gac 96Leu Cys Ile Ala Asp Phe Ile Arg Pro Arg Glu Gln Ala Val Lys Asp

20 25 30ggc caa gtg gac gtc atg cca ttc cag ctg gtc acc atg ggt aat cct 144Gly Gln Val Asp Val Met Pro Phe Gln Leu Val Thr Met Gly Asn Pro

35 40 45att gct gat ttc gcc aac gag ttg ttc gca gcc aat gaa tac cgc gag 192Ile Ala Asp Phe Ala Asn Glu Leu Phe Ala Ala Asn Glu Tyr Arg Glu

50 55 60tac ttg gaa gtt cac ggc atc ggc gtg cag ctc acc gaa gca ttg gcc 240Tyr Leu Glu Val His Gly Ile Gly Val Gln Leu Thr Glu Ala Leu Ala 65 70 75 80gag tac tgg cac tcc cga gtg cgc agc gaa ctc aagctg aac gac ggt 288Glu Tyr Trp His Ser Arg Val Arg Ser Glu Leu Lys Leu Asn Asp Gly

85 90 95gga tct gtc gct gat ttt gat cca gaa gac aag acc aag ttc ttc gac 336Gly Ser Val Ala Asp Phe Asp Pro Glu Asp Lys Thr Lys Phe Phe Asp

100 105 110ctg gat tac cgc ggc gcc cgc ttc tcc ttt ggt tac ggt tct tgc cct 384Leu Asp Tyr Arg Gly Ala Arg Phe Ser Phe Gly Tyr Gly Ser Cys Pro

115 120 125gat ctg gaa gac cgc gca aag ctg gtg gaa ttg ctc gag cca ggc cgt 432Asp Leu Glu Asp Arg Ala Lys Leu Val Glu Leu Leu Glu Pro Gly Arg

130 135 140atc ggc gtg gag ttg tcc gag gaa ctc cag ctg cac cca gag cag tcc 480Ile Gly Val Glu Leu Ser Glu Glu Leu Gln Leu His Pro Glu Gln Ser145 150 155 160aca gac gcg ttt gtg ctc tac cac cca gag gca aag tac ttt aac gtc 528Thr Asp Ala Phe Val Leu Tyr His Pro Glu Ala Lys Tyr Phe Asn Val

165170175 taacaccttt gagagggaaa act 551<210>210<211>176<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>210Ala Glu Arg Met Arg Phe Ser Phe Pro Arg Gln Gln Arg Gly Arg Phe 151015 Leu Cys Ile Ala Asp Phe Ile Arg Pro Arg Glu Gln Ala Val Lys Asp

20 25 30Gly Gln Val Asp Val Met Pro Phe Gln Leu Val Thr Met Gly Asn Pro

35 40 45Ile Ala Asp Phe Ala Asn Glu Leu Phe Ala Ala Asn Glu Tyr Arg Glu

50 55 60Tyr Leu Glu Val His Gly Ile Gly Val Gln Leu Thr Glu Ala Leu Ala 65 70 75 80Glu Tyr Trp HisSer Arg Val Arg Ser Glu Leu Lys Leu Asn Asp Gly

85 90 95Gly Ser Val Ala Asp Phe Asp Pro Glu Asp Lys Thr Lys Phe Phe Asp

100 105 110Leu Asp Tyr Arg Gly Ala Arg Phe Ser Phe Gly Tyr Gly Ser Cys Pro

115 120 125Asp Leu Glu Asp Arg Ala Lys Leu Val Glu Leu Leu Glu Pro Gly Arg

130 135 140Ile Gly Val Glu Leu Ser Glu Glu Leu Gln Leu His Pro Glu Gln Ser145 150 155 160Thr Asp Ala Phe Val Leu Tyr His Pro Glu Ala Lys Tyr Phe Asn Val

165170175<210>211<211>2599<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (2599)<223>RXN02198<400>211agactagtgg cgctttgcct gtgttgctta ggcggcgttg aaaatgaact acgaatgaaa 60agttcgggaa ttgtctaatc cgtactaagc tgtctacaca atg tct act tca gtt 115

Met Ser Thr Ser Val

1 5act tca cca gcc cac aac aac gca cat tcc tcc gaa ttt ttg gat gcg 163Thr Ser Pro Ala His Asn Asn Ala His Ser Ser Glu Phe Leu Asp Ala

10 15 20ttg gca aac cat gtg ttg atc ggc gac ggc gcc atg ggc acc cag ctc 211Leu Ala Asn His Val Leu Ile Gly Asp Gly Ala Met Gly Thr Gln Leu

25 30 35caa ggc ttt gac ctg gac gtg gaa aag gat ttc ctt gat ctg gag ggg 259Gln Gly Phe Asp Leu Asp Val Glu Lys Asp Phe Leu Asp Leu Glu Gly

40 45 50tgt aat gag att ctcaac gac acc cgc cct gat gtg ttg agg cag att 307Cys Asn Glu Ile Leu Asn Asp Thr Arg Pro Asp Val Leu Arg Gln Ile

55 60 65cac cgc gcc tac ttt gag gcg gga gct gac ttg gtt gag acc aat act 355His Arg Ala Tyr Phe Glu Ala Gly Ala Asp Leu Val Glu Thr Asn Thr 70 75 80 85ttt ggt tgc aac ctg ccg aac ttg gcg gat tat gac atc gct gat cgt 403Phe Gly Cys Asn Leu Pro Asn Leu Ala Asp Tyr Asp Ile Ala Asp Arg

90 95 100tgc cgt gag ctt gcc tac aag ggc act gca gtg gct agg gaa gtg gct 451Cys Arg Glu Leu Ala Tyr Lys Gly Thr Ala Val Ala Arg Glu Val Ala

105 110 115gat gag atg ggg ccg ggc cga aac ggc atg cgg cgt ttc gtg gtt ggt 499Asp Glu Met Gly Pro Gly Arg Asn Gly Met Arg Arg Phe Val Val Gly

120 125 130tcc ctg gga cct gga acg aag ctt cca tcg ctg ggc cat gca ccg tat 547Ser Leu Gly Pro Gly Thr Lys Leu Pro Ser Leu Gly His Ala Pro Tyr

135 140 145gca gat ttg cgt ggg cac tac aag gaa gca gcg ctt ggc atc atc gac 595Ala Asp Leu Arg Gly His Tyr Lys Glu Ala Ala Leu Gly Ile Ile Asp150 155 160 165ggt ggt ggc gat gcc ttt ttg att gag act gct cag gac ttg ctt cag 643Gly Gly Gly Asp Ala Phe Leu Ile Glu Thr Ala Gln Asp Leu Leu Gln

170 175 180gtc aag gct gcg gtt cac ggc gtt caa gat gcc atg gct gaa ctt gat 691Val Lys Ala Ala Val His Gly Val Gln Asp Ala Met Ala Glu Leu Asp

185 190 195aca ttc ttg ccc att att tgc cac gtc acc gta gag acc acc ggc acc 739Thr Phe Leu Pro Ile Ile Cys His Val Thr Val Glu Thr Thr Gly Thr

200 205 210atg ctc atg ggt tct gag atc ggt gcc gcg ttg aca gcg ctg cag cca 787Met Leu Met Gly Ser Glu Ile Gly Ala Ala Leu Thr Ala Leu Gln Pro

215 220 225ctg ggt atc gac atg att ggt ctg aac tgc gcc acc ggc cca gat gag 835Leu Gly Ile Asp Met Ile Gly Leu Asn Cys Ala Thr Gly Pro Asp Glu230 235 240 245atg agc gag cac ctg cgt tac ctg tcc aag cac gcc gat att cct gtg 883Met Ser Glu His Leu Arg Tyr Leu Ser Lys His Ala Asp Ile Pro Val

250 255 260tcg gtg atg cct aac gca ggt ctt cct gtc ctg ggt aaa aac ggt gca 931Ser Val Met Pro Asn Ala Gly Leu Pro Val Leu Gly Lys Asn Gly Ala

265 270 275gaa tac cca ctt gag gct gag gat ttg gcg cag gcg ctg gct gga ttc 979Glu Tyr Pro Leu Glu Ala Glu Asp Leu Ala Gln Ala Leu Ala Gly Phe

280 285 290gtc tcc gaa tat ggc ctg tcc atg gtg ggt ggt tgt tgt ggc acc aca 1027Val Ser Glu Tyr Gly Leu Ser Met Val Gly Gly Cys Cys Gly Thr Thr

295 300 305cct gag cac atc cgt gcg gtc cgc gat gcg gtg gtt ggt gtt cca gag 1075Pro Glu His Ile Arg Ala Val Arg Asp Ala Val Val Gly Val Pro Glu310 315 320 325cag gaa acc tcc aca ctg acc aag atc cct gca ggc cct gtt gag cag 1123Gln Glu Thr Ser Thr Leu Thr Lys Ile Pro Ala Gly Pro Val Glu Gln

330 335 340gcc tcc cgc gag gtg gag aaa gag gac tcc gtc gcg tcg ctg tac acc 1171Ala Ser Arg Glu Val Glu Lys Glu Asp Ser Val Ala Ser Leu Tyr Thr

345 350 355tcg gtg cca ttg tcc cag gaa acc ggc att tcc atg atc ggt gag cgc 1219Ser Val Pro Leu Ser Gln Glu Thr Gly Ile Ser Met Ile Gly Glu Arg

360 365 370acc aac tcc aac ggt tcc aag gca ttc cgt gag gca atg ctg tct ggc 1267Thr Asn Ser Asn Gly Ser Lys Ala Phe Arg Glu Ala Met Leu Ser Gly

375 380 385gat tgg gaa aag tgt gtg gat att gcc aag cag caa acc cgc gat ggt 1315Asp Trp Glu Lys Cys Val Asp Ile Ala Lys Gln Gln Thr Arg Asp Gly390 395 400 405gca cac atg ctg gat ctt tgt gtg gat tac gtg gga cga gac ggc acc 1363Ala His Met Leu Asp Leu Cys Val Asp Tyr Val Gly Arg Asp Gly Thr

410 415 420gcc gat atg gcg acc ttg gca gca ctt ctt gct acc agc tcc act ttg 1411Ala Asp Met Ala Thr Leu Ala Ala Leu Leu Ala Thr Ser Ser Thr Leu

425 430 435cca atc atg att gac tcc acc gag cca gag gtt att cgc aca ggc ctt 1459Pro Ile Met Ile Asp Ser Thr Glu Pro Glu Val Ile Arg Thr Gly Leu

440 445 450gag cac ttg ggt gga cga agc atc gtt aac tcc gtc aac ttt gaa gac 1507Glu His Leu Gly Gly Arg Ser Ile Val Asn Ser Val Asn Phe Glu Asp

455 460 465ggc gat ggc cct gag tcc cgc tac cag cgc atc atg aaa ctg gta aag 1555Gly Asp Gly Pro Glu Ser Arg Tyr Gln Arg Ile Met Lys Leu Val Lys470 475 480 485cag cac ggt gcg gcc gtg gtt gcg ctg acc att gat gag gaa ggc cag 1603Gln His Gly Ala Ala Val Val Ala Leu Thr Ile Asp Glu Glu Gly Gln

490 495 500gca cgt acc gct gag cac aag gtg cgc att gct aaa cga ctg att gac 1651Ala Arg Thr Ala Glu His Lys Val Arg Ile Ala Lys Arg Leu Ile Asp

505 510 515gat atc acc ggc agc tac ggc ctg gat atc aaa gac atc gtt gtg gac 1699Asp Ile Thr Gly Ser Tyr Gly Leu Asp Ile Lys Asp Ile Val Val Asp

520 525 530tgc ctg acc ttc ccg atc tct act ggc cag gaa gaa acc agg cga gat 1747Cys Leu Thr Phe Pro Ile Ser Thr Gly Gln Glu Glu Thr Arg Arg Asp

535 540 545ggc att gaa acc atc gaa gcc atc cgc gag ctg aag aag ctc tac cca 1795Gly Ile Glu Thr Ile Glu Ala Ile Arg Glu Leu Lys Lys Leu Tyr Pro550 555 560 565gaa atc cac acc acc ctg ggt ctg tcc aat att tcc ttc ggc ctg aac 1843Glu Ile His Thr Thr Leu Gly Leu Ser Asn Ile Ser Phe Gly Leu Asn

570 575 580cct gct gca cgc cag gtt ctt aac tct gtg ttc ctc aat gag tgc att 1891Pro Ala Ala Arg Gln Val Leu Asn Ser Val Phe Leu Asn Glu Cys Ile

585 590 595gag gct ggt ctg gac tct gcg att gcg cac agc tcc aag att ttg ccg 1939Glu Ala Gly Leu Asp Ser Ala Ile Ala His Ser Ser Lys Ile Leu Pro

600 605 610atg aac cgc att gat gat cgc cag cgc gaa gtg gcg ttg gat atg gtc 1987Met Asn Arg Ile Asp Asp Arg Gln Arg Glu Val Ala Leu Asp Met Val

615 620 625tat gat cgc cgc acc gag gat tac gat ccg ctg cag gaa ttc atg cag 2035Tyr Asp Arg Arg Thr Glu Asp Tyr Asp Pro Leu Gln Glu Phe Met Gln630 635 640 645ctg ttt gag ggc gtt tct gct gcc gat gcc aag gat gct cgc gct gaa 2083Leu Phe Glu Gly Val Ser Ala Ala Asp Ala Lys Asp Ala Arg Ala Glu

650 655 660cag ctg gcc gct atgcct ttg ttt gag cgt ttg gca cag cgc atc atc 2131Gln Leu Ala Ala Met Pro Leu Phe Glu Arg Leu Ala Gln Arg Ile Ile

665 670 675gac ggc gat aag aat ggc ctt gag gat gat ctg gaa gca ggc atg aag 2179Asp Gly Asp Lys Asn Gly Leu Glu Asp Asp Leu Glu Ala Gly Met Lys

680 685 690gag aag tct cct att gcg atc atc aac gag gac ctt ctc aac ggc atg 2227Glu Lys Ser Pro Ile Ala Ile Ile Asn Glu Asp Leu Leu Asn Gly Met

695 700 705aag acc gtg ggt gag ctg ttt ggt tcc gga cag atg cag ctg cca ttc 2275Lys Thr Val Gly Glu Leu Phe Gly Ser Gly Gln Met Gln Leu Pro Phe710 715 720 725gtg ctg caa tcg gca gaa acc atg aaa act gcg gtg gcc tat ttg gaa 2323Val Leu Gln Ser Ala Glu Thr Met Lys Thr Ala Val Ala Tyr Leu Glu

730 735 740ccg ttc atg gaa gag gaa gca gaa gct acc gga tct gcg cag gca gag 2371Pro Phe Met Glu Glu Glu Ala Glu Ala Thr Gly Ser Ala Gln Ala Glu

745 750 755ggc aag ggc aaa atc gtc gtg gcc acc gtc aag ggt gac gtg cac gat 2419Gly Lys Gly Lys Ile Val Val Ala Thr Val Lys Gly Asp Val His Asp

760 765 770atc ggc aag aac ttg gtg gac atc att ttg tcc aac aac ggt tac gac 2467Ile Gly Lys Asn Leu Val Asp Ile Ile Leu Ser Asn Asn Gly Tyr Asp

775 780 785gtg gtg aac ttg ggc atc aag cag cca ctg tcc gcc atg ttg gaa gca 2515Val Val Asn Leu Gly Ile Lys Gln Pro Leu Ser Ala Met Leu Glu Ala790 795 800 805gcg gaa gaa cac aaa gca gac gtc atc ggc atg tcg gga ctt ctt gtg 2563Ala Glu Glu His Lys Ala Asp Val Ile Gly Met Ser Gly Leu LeuVal

810 815 820aag tcc acc gtg gtg atg aag caa acc atc agc gac 2599Lys Ser Thr Val Val Met Lys Gln Thr Ile Ser Asp

825830<210>212<211>833<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>212Met Ser Thr Ser Val Thr Ser Pro Ala His Asn Asn Ala His Ser Ser 151015 Glu Phe Leu Asp Ala Leu Ala Asn His Val Leu Ile Gly Asp Gly Ala

20 25 30Met Gly Thr Gln Leu Gln Gly Phe Asp Leu Asp Val Glu Lys Asp Phe

35 40 45Leu Asp Leu Glu Gly Cys Asn Glu Ile Leu Asn Asp Thr Arg Pro Asp

50 55 60Val Leu Arg Gln Ile His Arg Ala Tyr Phe Glu Ala Gly Ala Asp Leu 65 70 75 80Val Glu Thr Asn Thr Phe Gly Cys Asn Leu Pro Asn Leu Ala Asp Tyr

85 90 95Asp Ile Ala Asp Arg Cys Arg Glu Leu Ala Tyr Lys Gly Thr Ala Val

100 105 110Ala Arg Glu Val Ala Asp Glu Met Gly Pro Gly Arg Asn Gly Met Arg

115 120 125Arg Phe Val Val Gly Ser Leu Gly Pro Gly Thr Lys Leu Pro Ser Leu

130 135 140Gly His Ala Pro Tyr Ala Asp Leu Arg Gly His Tyr Lys Glu Ala Ala145 150 155 160Leu Gly Ile Ile Asp Gly Gly Gly Asp Ala Phe Leu Ile Glu Thr Ala

165 170 175Gln Asp Leu Leu Gln Val Lys Ala Ala Val His Gly Val Gln Asp Ala

180 185 190Met Ala Glu Leu Asp Thr Phe Leu Pro Ile Ile Cys His Val Thr Val

195 200 205Glu Thr Thr Gly Thr Met Leu Met Gly Ser Glu Ile Gly Ala Ala Leu

210 215 220Thr Ala Leu Gln Pro Leu Gly Ile Asp Met Ile Gly Leu Asn Cys Ala225 230 235 240Thr Gly Pro Asp Glu Met Ser Glu His Leu Arg Tyr Leu Ser Lys His

245 250 255Ala Asp Ile Pro Val Ser Val Met Pro Asn Ala Gly Leu Pro Val Leu

260 265 270Gly Lys Asn Gly Ala Glu Tyr Pro Leu Glu Ala Glu Asp Leu Ala Gln

275 280 285Ala Leu Ala Gly Phe Val Ser Glu Tyr Gly Leu Ser Met Val Gly Gly

290 295 300Cys Cys Gly Thr Thr Pro Glu His Ile Arg Ala Val Arg Asp Ala Val305 310 315 320Val Gly Val Pro Glu Gln Glu Thr Ser Thr Leu Thr Lys Ile Pro Ala

325 330 335Gly Pro Val Glu Gln Ala Ser Arg Glu Val Glu Lys Glu Asp Ser Val

340 345 350Ala Ser Leu Tyr Thr Ser Val Pro Leu Ser Gln Glu Thr Gly Ile Ser

355 360 365Met Ile Gly Glu Arg Thr Asn Ser Asn Gly Ser Lys Ala Phe Arg Glu

370 375 380Ala Met Leu Ser Gly Asp Trp Glu Lys Cys Val Asp Ile Ala Lys Gln385 390 395 400Gln Thr Arg Asp Gly Ala His Met Leu Asp Leu Cys Val Asp Tyr Val

405 410415Gly Arg Asp Gly Thr Ala Asp Met Ala Thr Leu Ala Ala Leu Leu Ala

420 425 430Thr Ser Ser Thr Leu Pro Ile Met Ile Asp Ser Thr Glu Pro Glu Val

435 440 445Ile Arg Thr Gly Leu Glu His Leu Gly Gly Arg Ser Ile Val Asn Ser

450 455 460Val Asn Phe Glu Asp Gly Asp Gly Pro Glu Ser Arg Tyr Gln Arg Ile465 470 475 480Met Lys Leu Val Lys Gln His Gly Ala Ala Val Val Ala Leu Thr Ile

485 490 495Asp Glu Glu Gly Gln Ala Arg Thr Ala Glu His Lys Val Arg Ile Ala

500 505 510Lys Arg Leu Ile Asp Asp Ile Thr Gly Ser Tyr Gly Leu Asp Ile Lys

515 520 525Asp Ile Val Val Asp Cys Leu Thr Phe Pro Ile Ser Thr Gly Gln Glu

530 535 540Glu Thr Arg Arg Asp Gly Ile Glu Thr Ile Glu Ala Ile Arg Glu Leu545 550 555 560Lys Lys Leu Tyr Pro Glu Ile His Thr Thr Leu Gly Leu Ser Asn Ile

565 570 575Ser Phe Gly Leu Asn Pro Ala Ala Arg Gln Val Leu Asn Ser Val Phe

580 585 590Leu Asn Glu Cys Ile Glu Ala Gly Leu Asp Ser Ala Ile Ala His Ser

595 600 605Ser Lys Ile Leu Pro Met Asn Arg Ile Asp Asp Arg Gln Arg Glu Val

610 615 620Ala Leu Asp Met Val Tyr Asp Arg Arg Thr Glu Asp Tyr Asp Pro Leu625 630 635 640Gln Glu Phe Met GlnLeu Phe Glu Gly Val Ser Ala Ala Asp Ala Lys

645 650 655Asp Ala Arg Ala Glu Gln Leu Ala Ala Met Pro Leu Phe Glu Arg Leu

660 665 670Ala Gln Arg Ile Ile Asp Gly Asp Lys Asn Gly Leu Glu Asp Asp Leu

675 680 685Glu Ala Gly Met Lys Glu Lys Ser Pro Ile Ala Ile Ile Asn Glu Asp

690 695 700Leu Leu Asn Gly Met Lys Thr Val Gly Glu Leu Phe Gly Ser Gly Gln705 710 715 720Met Gln Leu Pro Phe Val Leu Gln Ser Ala Glu Thr Met Lys Thr Ala

725 730 735Val Ala Tyr Leu Glu Pro Phe Met Glu Glu Glu Ala Glu Ala Thr Gly

740 745 750Ser Ala Gln Ala Glu Gly Lys Gly Lys Ile Val Val Ala Thr Val Lys

755 760 765Gly Asp Val His Asp Ile Gly Lys Asn Leu Val Asp Ile Ile Leu Ser

770 775 780Asn Asn Gly Tyr Asp Val Val Asn Leu Gly Ile Lys Gln Pro Leu Ser785 790 795 800Ala Met Leu Glu Ala Ala Glu Glu His Lys Ala Asp Val Ile Gly Met

805 810 815Ser Gly Leu Leu Val Lys Ser Thr Val Val Met Lys Gln Thr Ile Ser

820825830 Asp<210>213<211>2578<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (2578)<223>FRXA02198<400>213agactagtgg cgctttgcct gtgttgctta ggcggcgttg aaaatgaact acgaatgaaa 60agttcgggaa ttgtctaatc cgtactaagc tgtctacaca atg tct act tca gtt 115

Met Ser Thr Ser Val

1 5act tca cca gcc cac aac aac gca cat tcc tcc gaa ttt ttg gat gcg 163Thr Ser Pro Ala His Asn Asn Ala His Ser Ser Glu Phe Leu Asp Ala

10 15 20ttg gca aac cat gtg ttg atc ggc gac ggc gcc atg ggc acc cag ctc 211Leu Ala Asn His Val Leu Ile Gly Asp Gly Ala Met Gly Thr Gln Leu

25 30 35caa ggc ttt gac ctg gac gtg gaa aag gat ttc ctt gat ctg gag ggg 259Gln Gly Phe Asp Leu Asp Val Glu Lys Asp Phe Leu Asp Leu Glu Gly

40 45 50tgt aat gag att ctc aac gac acc cgc cct gat gtg ttg agg cag att 307Cys Asn Glu Ile Leu Asn Asp Thr Arg Pro Asp Val Leu Arg Gln Ile

55 60 65cac cgc gcc tac ttt gag gcg gga gct gac ttg gtt gag acc aat act 355His Arg Ala Tyr Phe Glu Ala Gly Ala Asp Leu Val Glu Thr Asn Thr 70 75 80 85ttt ggt tgc aac ctg ccg aac ttg gcg gat tat gac atc gct gat cgt 403Phe Gly Cys Asn Leu Pro Asn Leu Ala Asp Tyr Asp Ile Ala Asp Arg

90 95 100tgc cgt gag ctt gcc tac aag ggc act gca gtg gct agg gaa gtg gct 451Cys Arg Glu Leu Ala Tyr Lys Gly Thr Ala Val Ala Arg Glu Val Ala

105 110 115gat gag atg ggg ccg ggc cga aac ggc atg cgg cgt ttc gtg gtt ggt 499Asp Glu Met Gly Pro Gly Arg Asn Gly Met Arg Arg Phe Val Val Gly

120 125 130tcc ctg gga cct gga acg aag ctt cca tcg ctg ggc cat gca ccg tat 547Ser Leu Gly Pro Gly Thr Lys LeuPro Ser Leu Gly His Ala Pro Tyr

135 140 145gca gat ttg cgt ggg cac tac aag gaa gca gcg ctt ggc atc atc gac 595Ala Asp Leu Arg Gly His Tyr Lys Glu Ala Ala Leu Gly Ile Ile Asp150 155 160 165ggt ggt ggc gat gcc ttt ttg att gag act gct cag gac ttg ctt cag 643Gly Gly Gly Asp Ala Phe Leu Ile Glu Thr Ala Gln Asp Leu Leu Gln

170 175 180gtc aag gct gcg gtt cac ggc gtt caa gat gcc atg gct gaa ctt gat 691Val Lys Ala Ala Val His Gly Val Gln Asp Ala Met Ala Glu Leu Asp

185 190 195aca ttc ttg ccc att att tgc cac gtc acc gta gag acc acc ggc acc 739Thr Phe Leu Pro Ile Ile Cys His Val Thr Val Glu Thr Thr Gly Thr

200 205 210atg ctc atg ggt tct gag atc ggt gcc gcg ttg aca gcg ctg cag cca 787Met Leu Met Gly Ser Glu Ile Gly Ala Ala Leu Thr Ala Leu Gln Pro

215 220 225ctg ggt atc gac atg att ggt ctg aac tgc gcc acc ggc cca gat gag 835Leu GIy Ile Asp Met Ile Gly Leu Asn Cys Ala Thr Gly Pro Asp Glu230 235 240 245atg agc gag cac ctg cgt tac ctg tcc aag cac gcc gat att cct gtg 883Met Ser Glu His Leu Arg Tyr Leu Ser Lys His Ala Asp Ile Pro Val

250 255 260tcg gtg atg cct aac gca ggt ctt cct gtc ctg ggt aaa aac ggt gca 931Ser Val Met Pro Asn Ala Gly Leu Pro Val Leu Gly Lys Asn Gly Ala

265 270 275gaa tac cca ctt gag gct gag gat ttg gcg cag gcg ctg gct gga ttc 979Glu Tyr Pro Leu Glu Ala Glu Asp Leu Ala Gln Ala Leu Ala Gly Phe

280 285290gtc tcc gaa tat ggc ctg tcc atg gtg ggt ggt tgt tgt ggc acc aca 1027Val Ser Glu Tyr Gly Leu Ser Met Val Gly Gly Cys Cys Gly Thr Thr

295 300 305cct gag cac atc cgt gcg gtc cgc gat gcg gtg gtt ggt gtt cca gag 1075Pro Glu His Ile Arg Ala Val Arg Asp Ala Val Val Gly Val Pro Glu310 315 320 325cag gaa acc tcc aca ctg acc aag atc cct gca ggc cct gtt gag cag 1123Gln Glu Thr Ser Thr Leu Thr Lys Ile Pro Ala Gly Pro Val Glu Gln

330 335 340gcc tcc cgc gag gtg gag aaa gag gac tcc gtc gcg tcg ctg tac acc 1171Ala Ser Arg Glu Val Glu Lys Glu Asp Ser Val Ala Ser Leu Tyr Thr

345 350 355tcg gtg cca ttg tcc cag gaa acc ggc att tcc atg atc ggt gag cgc 1219Ser Val Pro Leu Ser Gln Glu Thr Gly Ile Ser Met Ile Gly Glu Arg

360 365 370acc aac tcc aac ggt tcc aag gca ttc cgt gag gca atg ctg tct ggc 1267Thr Asn Ser Asn Gly Ser Lys Ala Phe Arg Glu Ala Met Leu Ser Gly

375 380 385gat tgg gaa aag tgt gtg gat att gcc aag cag caa acc cgc gat ggt 1315Asp Trp Glu Lys Cys Val Asp Ile Ala Lys Gln Gln Thr Arg Asp Gly390 395 400 405gca cac atg ctg gat ctt tgt gtg gat tac gtg gga cga gac ggc acc 1363Ala His Met Leu Asp Leu Cys Val Asp Tyr Val Gly Arg Asp Gly Thr

410 415 420gcc gat atg gcg acc ttg gca gca ctt ctt gct acc agc tcc act ttg 1411Ala Asp Met Ala Thr Leu Ala Ala Leu Leu Ala Thr Ser Ser Thr Leu

425 430 435cca atc atg att gac tcc acc gag cca gag gtt att cgc aca ggc ctt 1459Pro Ile Met Ile Asp Ser Thr Glu Pro Glu Val Ile Arg Thr Gly Leu

440 445 450gag cac ttg ggt gga cga agc atc gtt aac tcc gtc aac ttt gaa gac 1507Glu His Leu Gly Gly Arg Ser Ile Val Asn Ser Val Asn Phe Glu Asp

455 460 465ggc gat ggc cct gag tcc cgc tac cag cgc atc atg aaa ctg gta aag 1555Gly Asp Gly Pro Glu Ser Arg Tyr Gln Arg Ile Met Lys Leu Val Lys470 475 480 485cag cac ggt gcg gcc gtg gtt gcg ctg acc att gat gag gaa ggc cag 1603Gln His Gly Ala Ala Val Val Ala Leu Thr Ile Asp Glu Glu Gly Gln

490 495 500gca cgt acc gct gag cac aag gtg cgc att gct aaa cga ctg att gac 1651Ala Arg Thr Ala Glu His Lys Val Arg Ile Ala Lys Arg Leu Ile Asp

505 510 515gat atc acc ggc agc tac ggc ctg gat atc aaa gac atc gtt gtg gac 1699Asp Ile Thr Gly Ser Tyr Gly Leu Asp Ile Lys Asp Ile Val Val Asp

520 525 530tgc ctg acc ttc ccg atc tct act ggc cag gaa gaa acc agg cga gat 1747Cys Leu Thr Phe Pro Ile Ser Thr Gly Gln Glu Glu Thr Arg Arg Asp

535 540 545ggc att gaa acc atc gaa gcc atc cgc gag ctg aag aag ctc tac cca 1795Gly Ile Glu Thr Ile Glu Ala Ile Arg Glu Leu Lys Lys Leu Tyr Pro550 555 560 565gaa atc cac acc acc ctg ggt ctg tcc aat att tcc ttc ggc ctg aac 1843Glu Ile His Thr Thr Leu Gly Leu Ser Asn Ile Ser Phe Gly Leu Asn

570 575 580cct gct gca cgc cag gtt ctt aac tct gtg ttc ctc aat gag tgc att 1891Pro Ala Ala Arg Gln Val Leu Asn Ser Val Phe Leu Asn Glu Cys Ile

585590 595gag gct ggt ctg gac tct gcg att gcg cac agc tcc aag att ttg ccg 1939Glu Ala Gly Leu Asp Ser Ala Ile Ala His Ser Ser Lys Ile Leu Pro

600 605 610atg aac cgc att gat gat cgc cag cgc gaa gtg gcg ttg gat atg gtc 1987Met Asn Arg Ile Asp Asp Arg Gln Arg Glu Val Ala Leu Asp Met Val

615 620 625tat gat cgc cgc acc gag gat tac gat ccg ctg cag gaa ttc atg cag 2035Tyr Asp Arg Arg Thr Glu Asp Tyr Asp Pro Leu Gln Glu Phe Met Gln630 635 640 645ctg ttt gag ggc gtt tct gct gcc gat gcc aag gat gct cgc gct gaa 2083Leu Phe Glu Gly Val Ser Ala Ala Asp Ala Lys Asp Ala Arg Ala Glu

650 655 660cag ctg gcc gct atg cct ttg ttt gag cgt ttg gca cag cgc atc atc 2131Gln Leu Ala Ala Met Pro Leu Phe Glu Arg Leu Ala Gln Arg Ile Ile

665 670 675gac ggc gat aag aat ggc ctt gag gat gat ctg gaa gca ggc atg aag 2179Asp Gly Asp Lys Asn Gly Leu Glu Asp Asp Leu Glu Ala Gly Met Lys

680 685 690gag aag tct cct att gcg atc atc aac gag gac ctt ctc aac ggc atg 2227Glu Lys Ser Pro Ile Ala Ile Ile Asn Glu Asp Leu Leu Asn Gly Met

695 700 705aag acc gtg ggt gag ctg ttt ggt tcc gga cag atg cag ctg cca ttc 2275Lys Thr Val Gly Glu Leu Phe Gly Ser Gly Gln Met Gln Leu Pro Phe710 715 720 725gtg ctg caa tcg gca gaa acc atg aaa act gcg gtg gcc tat ttg gaa 2323Val Leu Gln Ser Ala Glu Thr Met Lys Thr Ala Val Ala Tyr Leu Glu

730 735 740ccg ttc atg gaa gag gaa gca gaa gct acc gga tct gcg cag gca gag 2371Pro Phe Met Glu Glu Glu Ala Glu Ala Thr Gly Ser Ala Gln Ala Glu

745 750 755ggc aag ggc aaa atc gtc gtg gcc acc gtc aag ggt gac gtg cac gat 2419Gly Lys Gly Lys Ile Val Val Ala Thr Val Lys Gly Asp Val His Asp

760 765 770atc ggc aag aac ttg gtg gac atc att ttg tcc aac aac ggt tac gac 2467Ile Gly Lys Asn Leu Val Asp Ile Ile Leu Ser Asn Asn Gly Tyr Asp

775 780 785gtg gtg aac ttg ggc atc aag cag cca ctg tcc gcc atg ttg gaa gca 2515Val Val Asn Leu Gly Ile Lys Gln Pro Leu Ser Ala Met Leu Glu Ala790 795 800 805gcg gaa gaa cac aaa gca gac gtc atc ggc atg tcg gga ctt ctt gtg 2563Ala Glu Glu His Lys Ala Asp Val Ile Gly Met Ser Gly Leu Leu Val

810 815 820aag tcc acc gtg gtg 2578Lys Ser Thr Val Val

825<210>214<211>826<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>214Met Ser Thr Ser Val Thr Ser Pro Ala His Asn Asn Ala His Ser Ser 151015 Glu Phe Leu Asp Ala Leu Ala Asn His Val Leu Ile Gly Asp Gly Ala

20 25 30Met Gly Thr Gln Leu Gln Gly Phe Asp Leu Asp Val Glu Lys Asp Phe

35 40 45Leu Asp Leu Glu Gly Cys Asn Glu Ile Leu Asn Asp Thr Arg Pro Asp

50 55 60Val Leu Arg Gln Ile His Arg Ala Tyr Phe Glu Ala Gly Ala Asp Leu 65 70 75 80Val Glu Thr Asn Thr Phe Gly Cys Asn Leu Pro Asn Leu Ala Asp Tyr

85 9095Asp Ile Ala Asp Arg Cys Arg Glu Leu Ala Tyr Lys Gly Thr Ala Val

100 105 110Ala Arg Glu Val Ala Asp Glu Met Gly Pro Gly Arg Asn Gly Met Arg

115 120 125Arg Phe Val Val Gly Ser Leu Gly Pro Gly Thr Lys Leu Pro Ser Leu

130 135 140Gly His Ala Pro Tyr Ala Asp Leu Arg Gly His Tyr Lys Glu Ala Ala145 150 155 160Leu Gly Ile Ile Asp Gly Gly Gly Asp Ala Phe Leu Ile Glu Thr Ala

165 170 175Gln Asp Leu Leu Gln Val Lys Ala Ala Val His Gly Val Gln Asp Ala

180 185 190Met Ala Glu Leu Asp Thr Phe Leu Pro Ile Ile Cys His Val Thr Val

195 200 205Glu Thr Thr Gly Thr Met Leu Met Gly Ser Glu Ile Gly Ala Ala Leu

210 215 220Thr Ala Leu Gln Pro Leu Gly Ile Asp Met Ile Gly Leu Asn Cys Ala225 230 235 240Thr Gly Pro Asp Glu Met Ser Glu His Leu Arg Tyr Leu Ser Lys His

245 250 255Ala Asp Ile Pro Val Ser Val Met Pro Asn Ala Gly Leu Pro Val Leu

260 265 270Gly Lys Asn Gly Ala Glu Tyr Pro Leu Glu Ala Glu Asp Leu Ala Gln

275 280 285Ala Leu Ala Gly Phe Val Ser Glu Tyr Gly Leu Ser Met Val Gly Gly

290 295 300Cys Cys Gly Thr Thr Pro Glu His Ile Arg Ala Val Arg Asp Ala Val305 310 315320Val Gly Val Pro Glu Gln Glu Thr Ser Thr Leu Thr Lys Ile Pro Ala

325 330 335Gly Pro Val Glu Gln Ala Ser Arg Glu Val Glu Lys Glu Asp Ser Val

340 345 350Ala Ser Leu Tyr Thr Ser Val Pro Leu Ser Gln Glu Thr Gly Ile Ser

355 360 365Met Ile Gly Glu Arg Thr Asn Ser Asn Gly Ser Lys Ala Phe Arg Glu

370 375 380Ala Met Leu Ser Gly Asp Trp Glu Lys Cys Val Asp Ile Ala Lys Gln385 390 395 400Gln Thr Arg Asp Gly Ala His Met Leu Asp Leu Cys Val Asp Tyr Val

405 410 415Gly Arg Asp Gly Thr Ala Asp Met Ala Thr Leu Ala Ala Leu Leu Ala

420 425 430Thr Ser Ser Thr Leu Pro Ile Met Ile Asp Ser Thr Glu Pro Glu Val

435 440 445Ile Arg Thr Gly Leu Glu His Leu Gly Gly Arg Ser Ile Val Asn Ser

450 455 460Val Asn Phe Glu Asp Gly Asp Gly Pro Glu Ser Arg Tyr Gln Arg Ile465 470 475 480Met Lys Leu Val Lys Gln His Gly Ala Ala Val Val Ala Leu Thr Ile

485 490 495Asp Glu Glu Gly Gln Ala Arg Thr Ala Glu His Lys Val Arg Ile Ala

500 505 510Lys Arg Leu Ile Asp Asp Ile Thr Gly Ser Tyr Gly Leu Asp Ile Lys

515 520 525Asp Ile Val Val Asp Cys Leu Thr Phe Pro Ile Ser Thr Gly Gln Glu

530 535540Glu Thr Arg Arg Asp Gly Ile Glu Thr Ile Glu Ala Ile Arg Glu Leu545 550 555 560Lys Lys Leu Tyr Pro Glu Ile His Thr Thr Leu Gly Leu Ser Asn Ile

565 570 575Ser Phe Gly Leu Asn Pro Ala Ala Arg Gln Val Leu Asn Ser Val Phe

580 585 590Leu Asn Glu Cys Ile Glu Ala Gly Leu Asp Ser Ala Ile Ala His Ser

595 600 605Ser Lys Ile Leu Pro Met Asn Arg Ile Asp Asp Arg Gln Arg Glu Val

610 615 620Ala Leu Asp Met Val Tyr Asp Arg Arg Thr Glu Asp Tyr Asp Pro Leu625 630 635 640Gln Glu Phe Met Gln Leu Phe Glu Gly Val Ser Ala Ala Asp Ala Lys

645 650 655Asp Ala Arg Ala Glu Gln Leu Ala Ala Met Pro Leu Phe Glu Arg Leu

660 665 670Ala Gln Arg Ile Ile Asp Gly Asp Lys Asn Gly Leu Glu Asp Asp Leu

675 680 685Glu Ala Gly Met Lys Glu Lys Ser Pro Ile Ala Ile Ile Asn Glu Asp

690 695 700Leu Leu Asn Gly Met Lys Thr Val Gly Glu Leu Phe Gly Ser Gly Gln705 710 715 720Met Gln Leu Pro Phe Val Leu Gln Ser Ala Glu Thr Met Lys Thr Ala

725 730 735Val Ala Tyr Leu Glu Pro Phe Met Glu Glu Glu Ala Glu Ala Thr Gly

740 745 750Ser Ala Gln Ala Glu Gly Lys Gly Lys Ile Val Val Ala Thr Val Lys

755 760 765GlyAsp Val His Asp Ile Gly Lys Asn Leu Val Asp Ile Ile Leu Ser

770 775 780Asn Asn Gly Tyr Asp Val Val Asn Leu Gly Ile Lys Gln Pro Leu Ser785 790 795 800Ala Met Leu Glu Ala Ala Glu Glu His Lys Ala Asp Val Ile Gly Met

805 810 815Ser Gly Leu Leu Val Lys Ser Thr Val Val

820825<210>215<211>621<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (598)<223>RXN03074<400>215tttgtgggca atctggtttt ttcgtaattg tgtgggatga atctcttaaa aattcacatt 60tagcaggaca agcatactgt tttagttcta tgctgtgggc atg act caa agt gct 115

Met Thr Gln Ser Ala

1 5cca gaa ttc att gcc acc gca gac ctc gta gac atc atc ggc gac aac 163Pro Glu Phe Ile Ala Thr Ala Asp Leu Val Asp Ile Ile Gly Asp Asn

10 15 20gcg caa tca tgc gac act cag ttt caa aac ctt gga ggt gcc aca gaa 211Ala Gln Ser Cys Asp Thr Gln Phe Gln Asn Leu Gly Gly Ala Thr Glu

25 30 35ttc cac gga ata ata acc acc gtg aaa tgc ttc caa gac aac gcc ctc 259Phe His Gly Ile Ile Thr Thr Val Lys Cys Phe Gln Asp Asn Ala Leu

40 45 50ctg aaa tcc atc ctg agc gag gat aat cct ggg gga gtg ctg gtt atc 307Leu Lys Ser Ile Leu Ser Glu Asp Asn Pro Gly Gly Val Leu Val Ile

55 60 65gat ggc gac gca tcc gtg cac acc gcg cta gtt ggc gac atc att gca 355Asp Gly Asp Ala Ser Val His Thr Ala Leu Val Gly Asp Ile IleAla 70 75 80 85gga ctt gga aaa gat cat ggt tgg tcc gga gta att gtc aac gga gca 403Gly Leu Gly Lys Asp His Gly Trp Ser Gly Val Ile Val Asn Gly Ala

90 95 100att cga gac tcc gca gtc atc ggc acc atg acc ttt ggt tgt aaa gcc 451Ile Arg Asp Ser Ala Val Ile Gly Thr Met Thr Phe Gly Cys Lys Ala

105 110 115ctt gga acc aac ccg cgg aaa tcc act aaa act ggt tcc ggc gaa cga 499Leu Gly Thr Asn Pro Arg Lys Ser Thr Lys Thr Gly Ser Gly Glu Arg

120 125 130gac gta gtg gta tcg att ggt ggc att gac ttc att cct ggt cat tac 547Asp Val Val Val Ser Ile Gly Gly Ile Asp Phe Ile Pro Gly His Tyr

135140145 gtc tac gcg gac tct gac gga att atc gtc acc gag gcg cca att aag 595Val Tyr Ala Asp Ser Asp Gly Ile Ile Val Thr Glu Ala Pro Ile Lys 150155160165 cag taatttgttt tgacgacgca gta 621Gln<210>216<211>166<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>216Met Thr Gln Ser Ala Pro Glu Phe Ile Ala Thr Ala Asp Leu Val Asp 151015 Ile Ile Gly Asp Asn Ala Gln Ser Cys Asp Thr Gln Phe Gln Asn Leu

20 25 30Gly Gly Ala Thr Glu Phe His Gly Ile Ile Thr Thr Val Lys Cys Phe

35 40 45Gln Asp Asn Ala Leu Leu Lys Ser Ile Leu Ser Glu Asp Asn Pro Gly

50 55 60Gly Val Leu Val Ile Asp Gly Asp Ala Ser Val His Thr Ala Leu Val 65 70 75 80Gly Asp Ile Ile Ala Gly Leu Gly Lys Asp His Gly Trp Ser Gly Val

85 90 95Ile Val Asn Gly Ala Ile Arg Asp Ser Ala Val Ile Gly Thr Met Thr

100 105 110Phe Gly Cys Lys Ala Leu Gly Thr Asn Pro Arg Lys Ser Thr Lys Thr

115 120 125Gly Ser Gly Glu Arg Asp Val Val Val Ser Ile Gly Gly Ile Asp Phe

130 135 140Ile Pro Gly His Tyr Val Tyr Ala Asp Ser Asp Gly Ile Ile Val Thr145 150 155 160Glu Ala Pro Ile Lys Gln

165<210>217<211>621<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (598)<223>FRXA02906<400>217tttgtgggca atctggtttt ttcgtaattg tgtgggatga atctcttaaa aattcacatt 60tagcaggaca agcatactgt tttagttcta tgctgtgggc atg act caa agt gct 115

Met Thr Gln Ser Ala

1 5cca gaa ttc att gcc acc gca gac ctc gta gac atc atc ggc gac aac 163Pro Glu Phe Ile Ala Thr Ala Asp Leu Val Asp Ile Ile Gly Asp Asn

10 15 20gcg caa tca tgc gac act cag ttt caa aac ctt gga ggt gcc aca gaa 211Ala Gln Ser Cys Asp Thr Gln Phe Gln Asn Leu Gly Gly Ala Thr Glu

25 30 35ttc cac gga ata ata acc acc gtg aaa tgc ttc caa gac aac gcc ctc 259Phe His Gly Ile Ile Thr Thr Val Lys Cys Phe Gln Asp Asn Ala Leu

40 45 50ctg aaa tcc atc ctg agc gag gat aat cct ggg gga gtg ctg gtt atc 307Leu Lys Ser Ile Leu Ser Glu Asp Asn Pro Gly Gly Val Leu Val Ile

55 60 65gat ggc gac gca tcc gtg cac acc gcg cta gtt ggc gac atc att gca 355Asp Gly Asp Ala Ser Val His Thr Ala Leu Val Gly Asp Ile Ile Ala 70 75 80 85gga ctt gga aaa gat cat ggt tgg tcc gga gta att gtc aac gga gca 403Gly Leu Gly Lys Asp His Gly Trp Ser Gly Val Ile Val Asn Gly Ala

90 95 100att cga gac tcc gca gtc atc ggc acc atg acc ttt ggt tgt aaa gcc 451Ile Arg Asp Ser Ala Val Ile Gly Thr Met Thr Phe Gly Cys Lys Ala

105 110 115ctt gga acc aac ccg cgg aaa tcc act aaa act ggt tcc ggc gaa cga 499Leu Gly Thr Asn Pro Arg Lys Ser Thr Lys Thr Gly Ser Gly Glu Arg

120 125 130gac gta gtg gta tcg att ggt ggc att gac ttc att cct ggt cat tac 547Asp Val Val Val Ser Ile Gly Gly Ile Asp Phe Ile Pro Gly His Tyr

135140145 gtc tac gcg gac tct gac gga att atc gtc acc gag gcg cca att aag 595Val Tyr Ala Asp Ser Asp Gly Ile Ile Val Thr Glu Ala Pro Ile Lys 150155160165 cag taatttgttt tgacgacgca gta 621Gln<210>218<211>166<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>218Met Thr Gln Ser Ala Pro Glu Phe Ile Ala Thr Ala Asp Leu Val Asp 151015 Ile Ile Gly Asp Asn Ala Gln Ser Cys Asp Thr Gln Phe Gln Asn Leu

20 25 30Gly Gly Ala Thr Glu Phe His Gly Ile Ile Thr Thr Val Lys Cys Phe

35 40 45Gln Asp Asn Ala Leu Leu Lys Ser Ile Leu Ser Glu Asp Asn Pro Gly

50 55 60Gly Val Leu Val Ile Asp Gly Asp Ala Ser Val His Thr Ala Leu Val 65 70 75 80Gly Asp Ile Ile Ala Gly Leu Gly Lys Asp His Gly Trp Ser Gly Val

85 90 95Ile Val Asn Gly Ala Ile Arg Asp Ser Ala Val Ile Gly Thr Met Thr

100 105 110Phe Gly Cys Lys Ala Leu Gly Thr Asn Pro Arg Lys Ser Thr Lys Thr

115 120 125Gly Ser Gly Glu Arg Asp Val Val Val Ser Ile Gly Gly Ile Asp Phe

130 135 140Ile Pro Gly His Tyr Val Tyr Ala Asp Ser Asp Gly Ile Ile Val Thr145 150 155 160Glu Ala Pro Ile Lys Gln

165<210>219<211>1557<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1534)<223>RXN00132<400>219aacagcttca atcaattcgg tgtccactcc aacatgtaga gtggtgcgcg ttaaaaaagt 60tttcctaatt ttcattttct taaaaggagc tcgccaggac atg gca cag gtt atg 115

Met Ala Gln Val Met

1 5gac ttc aag gtt gcc gat ctt tea cta gca gag gca gga cgt cac cag 163Asp Phe Lys Val Ala Asp Leu Ser Leu Ala Glu Ala Gly Arg His Gln

10 15 20att cgt ctt gca gag tat gag atg cca ggt ctc atg cag ttg cgc aag 211Ile Arg Leu Ala Glu Tyr Glu Met Pro Gly Leu Met Gln Leu Arg Lys

25 30 35gaa ttc gca gac gag cag cct ttg aag ggc gcc cga att gct ggt tct 259Glu Phe Ala Asp Glu Gln Pro Leu Lys Gly Ala Arg Ile Ala Gly Ser

40 45 50atc cac atg acg gtc cag acc gcc gtg ctt att gag acc ctc act gct 307Ile His Met Thr Val Gln Thr Ala Val Leu Ile Glu Thr Leu Thr Ala

55 60 65ttg ggc gct gag gtt cgt tgg gct tcc tgc aac att ttc tcc acc cag 355Leu Gly Ala Glu Val Arg Trp Ala Ser Cys Asn Ile Phe Ser Thr Gln 70 75 80 85gat gag gct gca gcg gct atc gtt gtc ggc tcc ggc acc gtc gaa gag 403Asp Glu Ala Ala Ala Ala Ile Val Val Gly Ser Gly Thr Val Glu Glu

90 95 100cca gct ggt gtt cca gta ttc gcg tgg aag ggt gag tca ctg gag gag 451Pro Ala Gly Val Pro Val Phe Ala Trp Lys Gly Glu Ser Leu Glu Glu

105 110 115tac tgg tgg tgc atc aac cag atc ttc agc tgg ggc gat gag ctg cca 499Tyr Trp Trp Cys Ile Asn Gln Ile Phe Ser Trp Gly Asp Glu Leu Pro

120 125 130aac atg atc ctc gac gac ggc ggt gac gcc acc atg gct gtt att cgc 547Asn Met Ile Leu Asp Asp Gly Gly Asp Ala Thr Met Ala Val Ile Arg

135 140 145ggt cgc gaa tac gag cag gct ggt ctg gtt cca cca gca gag gcc aac 595Gly Arg Glu Tyr Glu Gln Ala Gly Leu Val Pro Pro Ala Glu Ala Asn150 155 160 165gat tcc gat gag tac atc gca ttc ttg ggc atg ctg cgt gag gtt ctt 643Asp Ser Asp Glu Tyr Ile Ala Phe Leu Gly Met Leu Arg Glu Val Leu

170 175 180gct gca gag cct ggc aag tgg ggc aag atc gct gag gcc gtt aag ggt 691Ala Ala Glu Pro Gly Lys Trp Gly Lys Ile Ala Glu Ala Val Lys Gly

185 190 195gtc acc gag gaa acc acc acc ggt gtg cac cgc ctg tac cac ttc gct 739Val Thr Glu Glu Thr Thr Thr Gly Val His Arg Leu Tyr His Phe Ala

200 205 210gaa gaa ggc gtg ctg cct ttc cca gcg atg aac gtc aac gac gct gtc 787Glu Glu Gly Val Leu Pro Phe Pro Ala Met Asn Val Asn Asp Ala Val

215 220 225acc aag tcc aag ttt gat aac aag tac ggc acc cgc cac tcc ctg atc 835Thr Lys Ser Lys Phe Asp Asn Lys Tyr Gly Thr Arg His Ser Leu Ile230 235 240 245gac ggc atc aac cgc gcc act gac atg ctc atg ggc ggc aag aac gtg 883Asp Gly Ile Asn Arg Ala Thr Asp Met Leu Met Gly Gly Lys Asn Val

250 255 260ctt gtc tgc ggt tac ggc gat gtc ggc aag ggc tgc gct gag gct ttc 931Leu Val Cys Gly Tyr Gly Asp Val Gly Lys Gly Cys Ala Glu Ala Phe

265 270 275gac ggc cag ggc gct cgc gtc aag gtc acc gaa gct gac cca atc aac 979Asp Gly Gln Gly Ala Arg Val Lys Val Thr Glu Ala Asp Pro Ile Asn

280 285 290gct ctt cag gct ctg atg gat ggc tac tct gtg gtc acc gtt gat gag 1027Ala Leu Gln Ala Leu Met Asp Gly Tyr Ser Val Val Thr Val Asp Glu

295 300 305gcc atc gag gac gcc gac arc gtg atc acc gcg acc ggc aac aag gac 1075Ala Ile Glu Asp Ala Asp Ile Val Ile Thr Ala Thr Gly Asn Lys Asp310 315 320 325atc att tcc ttc gag cag atg ctc aag atg aag gat cac gct ctg ctg 1123Ile Ile Ser Phe Glu Gln Met Leu Lys Met Lys Asp His Ala Leu Leu

330 335 340ggc aac atc ggt cac ttt gat aat gag atc gat atg cat tcc ctg ttg 1171Gly Asn Ile Gly His Phe Asp Asn Glu Ile Asp Met His Ser Leu Leu

345 350 355cac cgc gac gac gtc acc cgc acc acg atc aag cca cag gtc gac gag 1219His Arg Asp Asp Val Thr Arg Thr Thr Ile Lys Pro Gln Val Asp Glu

360 365 370ttc acc ttc tcc acc ggt cgc tcc atc atc gtc ctg tcc gaa ggt cgc 1267Phe Thr Phe Ser Thr Gly Arg Ser Ile Ile Val Leu Ser Glu Gly Arg

375 380 385ctg ttg aac ctt ggc aac gcc acc gga cac cca tca ttt gtc atg tcc 1315Leu Leu Asn Leu Gly Asn Ala Thr Gly His Pro Ser Phe Val Met Ser390 395 400 405aac tct ttc gcc gat cag acc att gcg cag atc gaa ctg ttc caa aac 1363Asn Ser Phe Ala Asp Gln Thr Ile Ala Gln Ile Glu Leu Phe Gln Asn

410 415 420gaa gga cag tac gag aac gag gtc tac cgt ctg cct aag gtt ctc gac 1411Glu Gly Gln Tyr Glu Asn Glu Val Tyr Arg Leu Pro Lys Val Leu Asp

425 430 435gaa aag gtg gca cgc atc cac gtt gag gct ctc ggc ggt cag ctc acc 1459Glu Lys Val Ala Arg Ile His Val Glu Ala Leu Gly Gly Gln Leu Thr

440 445 450gaa ctg acc aag gag cag gct gag tac atc ggc gtt gac gtt gca ggc 1507Glu Leu Thr Lys Glu Gln Ala Glu Tyr Ile Gly Val Asp Val Ala Gly

455460465 cca ttc aag ccg gag cac tac cgc tac taatgattgt cagcattgag 1554Pro Phe Lys Pro Glu His Tyr Arg Tyr 470475 gga 1557<210>220<211>478<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>220Met Ala Gln Val Met Asp Phe Lys Val Ala Asp Leu Ser Leu Ala Glu 151015 Ala Gly Arg His Gln Ile Arg Leu Ala Glu Tyr Glu Met Pro Gly Leu

20 25 30Met Gln Leu Arg Lys Glu Phe Ala Asp Glu Gln Pro Leu Lys Gly Ala

35 40 45Arg Ile Ala Gly Ser Ile His Met Thr Val Gln Thr Ala Val Leu Ile

50 55 60Glu Thr Leu Thr Ala Leu Gly Ala Glu Val Arg Trp Ala Ser Cys Asn 65 70 75 80Ile Phe Ser Thr Gln Asp Glu Ala Ala Ala Ala Ile Val Val Gly Ser

85 90 95Gly Thr Val Glu Glu Pro Ala Gly Val Pro Val Phe Ala Trp Lys Gly

100 105 110Glu Ser Leu Glu Glu Tyr Trp Trp Cys Ile Asn Gln Ile Phe Ser Trp

115 120 125Gly Asp Glu Leu Pro Asn Met Ile Leu Asp Asp Gly Gly Asp Ala Thr

130 135 140Met Ala Val Ile Arg Gly Arg Glu Tyr Glu Gln Ala Gly Leu Val Pro145 150 155 160Pro Ala Glu Ala Asn Asp Ser Asp Glu Tyr Ile Ala Phe Leu Gly Met

165 170 175Leu Arg Glu Val Leu Ala Ala Glu Pro Gly Lys Trp Gly Lys Ile Ala

180 185 190Glu Ala Val Lys Gly Val Thr Glu Glu Thr Thr Thr Gly Val His Arg

195 200 205Leu Tyr His Phe Ala Glu Glu Gly Val Leu Pro Phe Pro Ala Met Asn

210 215 220Val Asn Asp Ala Val Thr Lys Ser Lys Phe Asp Asn Lys Tyr Gly Thr225 230 235 240Arg His Ser Leu Ile Asp Gly Ile Asn Arg Ala Thr Asp Met Leu Met

245 250 255Gly Gly Lys Asn Val Leu Val Cys Gly Tyr Gly Asp Val Gly Lys Gly

260 265 270Cys Ala Glu Ala Phe Asp Gly Gln Gly Ala Arg Val Lys Val Thr Glu

275280 285Ala Asp Pro Ile Asn Ala Leu Gln Ala Leu Met Asp Gly Tyr Ser Val

290 295 300Val Thr Val Asp Glu Ala Ile Glu Asp Ala Asp Ile Val Ile Thr Ala305 310 315 320Thr Gly Asn Lys Asp Ile Ile Ser Phe Glu Gln Met Leu Lys Met Lys

325 330 335Asp His Ala Leu Leu Gly Asn Ile Gly His Phe Asp Asn Glu Ile Asp

340 345 350Met His Ser Leu Leu His Arg Asp Asp Val Thr Arg Thr Thr Ile Lys

355 360 365Pro Gln Val Asp Glu Phe Thr Phe Ser Thr Gly Arg Ser Ile Ile Val

370 375 380Leu Ser Glu Gly Arg Leu Leu Asn Leu Gly Asn Ala Thr Gly His Pro385 390 395 400Ser Phe Val Met Ser Asn Ser Phe Ala Asp Gln Thr Ile Ala Gln Ile

405 410 415Glu Leu Phe Gln Asn Glu Gly Gln Tyr Glu Asn Glu Val Tyr Arg Leu

420 425 430Pro Lys Val Leu Asp Glu Lys Val Ala Arg Ile His Val Glu Ala Leu

435 440 445Gly Gly Gln Leu Thr Glu Leu Thr Lys Glu Gln Ala Glu Tyr Ile Gly

450455460 Val Asp Val Ala Gly Pro Phe Lys Pro Glu His Tyr Arg Tyr 465470475<210>221<211>128<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (105)<223>FRXA00132<400>221cac gtt gag gct ctc ggc ggt cag ctc acc gaa ctg acc aag gag cag 48His Val Glu Ala Leu Gly Gly Gln Leu Thr Glu Leu Thr Lys Glu Gln 151015 gct gag tac atc ggc gtt gac gtt gca ggc cca ttc aag ccg gag cac 96Ala Glu Tyr Ile Gly Val Asp Val Ala Gly Pro Phe Lys Pro Glu His

20 25 30tac cgc tac taatgattgt cagcattgag gga 128Tyr Arg Tyr

35<210>222<211>35<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>222His Val Glu Ala Leu Gly Gly Gln Leu Thr Glu Leu Thr Lys Glu Gln 151015 Ala Glu Tyr Ile Gly Val Asp Val Ala Gly Pro Phe Lys Pro Glu His

20 25 30Tyr Arg Tyr

35<210>223<211>1396<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1396)<223>FRXA0l371<400>223aacagcttca atcaattcgg tgtccactcc aacatgtaga gtggtgcgcg ttaaaaaagt 60tttcctaatt ttcattttct taaaaggagc tcgccaggac atg gca cag gtt atg 115

Met Ala Gln Val Met

1 5gac ttc aag gtt gcc gat ctt tca cta gca gag gca gga cgt cac cag 163Asp Phe Lys Val Ala Asp Leu Ser Leu Ala Glu Ala Gly Arg His Gln

10 15 20att cgt ctt gca gag tat gag atg cca ggt ctc atg cag ttg cgc aag 211Ile Arg Leu Ala Glu Tyr Glu Met Pro Gly Leu Met Gln Leu Arg Lys

25 30 35gaa ttc gca gac gag cag cct ttg aag ggc gcc cga att gct ggt tct 259Glu Phe Ala Asp Glu Gln Pro Leu Lys Gly Ala Arg Ile Ala Gly Ser

40 45 50atc cac atg acg gtc cag acc gcc gtg ctt att gag acc ctc act gct 307Ile His Met Thr Val Gln Thr Ala Val Leu Ile Glu Thr Leu Thr Ala

55 60 65ttg ggc gct gag gtt cgt tgg gct tcc tgc aac att ttc tcc acc cag 355Leu Gly Ala Glu Val Arg Trp Ala Ser Cys Asn Ile Phe Ser Thr Gln 70 75 80 85gat gag gct gca gcg gct atc gtt gtc ggc tcc ggc acc gtc gaa gag 403Asp Glu Ala Ala Ala Ala Ile Val Val Gly Ser Gly Thr Val Glu Glu

90 95 100cca gct ggt gtt cca gta ttc gcg tgg aag ggt gag tca ctg gag gag 451Pro Ala Gly Val Pro Val Phe Ala Trp Lys Gly Glu Ser Leu Glu Glu

105 110 115tac tgg tgg tgc atc aac cag atc ttc agc tgg ggc gat gag ctg cca 499Tyr Trp Trp Cys Ile Asn Gln Ile Phe Ser Trp Gly Asp Glu Leu Pro

120 125 130aac atg atc ctc gac gac ggc ggt gac gcc acc atg gct gtt att cgc 547Asn Met Ile Leu Asp Asp Gly Gly Asp Ala Thr Met Ala Val Ile Arg

135 140 145ggt cgc gaa tac gag cag gct ggt ctg gtt cca cca gca gag gcc aac 595Gly Arg Glu Tyr Glu Gln Ala Gly Leu Val Pro Pro Ala Glu Ala Asn150 155 160 165gat tcc gat gag tac atc gca ttc ttg ggc atg ctg cgt gag gtt ctt 643Asp Ser Asp Glu Tyr Ile Ala Phe Leu Gly Met Leu Arg Glu Val Leu

170 175 180gct gca gag cct ggc aag tgg ggc aag atc gct gag gcc gtt aag ggt 691Ala Ala Glu Pro Gly Lys Trp Gly Lys Ile Ala Glu Ala Val Lys Gly

185 190 195gtc acc gag gaa acc acc acc ggt gtg cac cgc ctg tac cac ttc gct 739Val Thr Glu Glu Thr Thr Thr Gly Val His Arg Leu Tyr His Phe Ala

200 205 210gaa gaa ggc gtg ctg cct ttc cca gcg atg aac gtc aac gac gct gtc 787Glu Glu Gly Val Leu Pro Phe Pro Ala Met Asn Val Asn Asp Ala Val

215 220 225acc aag tcc aag ttt gat aac aag tac ggc acc cgc cac tcc ctg atc 835Thr Lys Ser Lys Phe Asp Asn Lys Tyr Gly Thr Arg His Ser Leu Ile230 235 240 245gac ggc atc aac cgc gcc act gac atg ctc atg ggc ggc aag aac gtg 883Asp Gly Ile Asn Arg Ala Thr Asp Met Leu Met Gly Gly Lys Asn Val

250 255 260ctt gtc tgc ggt tac ggc gat gtc ggc aag ggc tgc gct gag gct ttc 931Leu Val Cys Gly Tyr Gly Asp Val Gly Lys Gly Cys Ala Glu Ala Phe

265 270 275gac ggc cag ggc gct cgc gtc aag gtc acc gaa gct gac cca atc aac 979Asp Gly Gln Gly Ala Arg Val Lys Val Thr Glu Ala Asp Pro Ile Asn

280 285 290gct ctt cag gct ctg atg gat ggc tac tct gtg gtc acc gtt gat gag 1027Ala Leu Gln Ala Leu Met Asp Gly Tyr Ser Val Val Thr Val Asp Glu

295 300 305gcc atc gag gac gcc gac atc gtg atc acc gcg acc ggc aac aag gac 1075Ala Ile Glu Asp Ala Asp Ile Val Ile Thr Ala Thr Gly Asn Lys Asp310 315 320 325atc att tcc ttc gag cag atg ctc aag atg aag gat cac gct ctg ctg 1123Ile Ile Ser Phe Glu Gln Met Leu Lys Met Lys Asp His Ala Leu Leu

330 335 340ggc aac atc ggt cac ttt gat aat gag atc gat atg cat tcc ctg ttg 1171Gly Asn Ile Gly His Phe Asp Asn Glu Ile Asp Met His Ser Leu Leu

345 350 355cac cgc gac gac gtc acc cgc acc acg atc aag cca cag gtc gac gag 1219His Arg Asp Asp Val Thr Arg Thr Thr Ile Lys Pro Gln Val Asp Glu

360 365 370ttc acc ttc tcc acc ggt cgc tcc atc atc gtc ctg tcc gaa ggt cgc 1267Phe Thr Phe Ser Thr Gly Arg Ser Ile Ile Val Leu Ser Glu Gly Arg

375 380 385ctg ttg aac ctt ggc aac gcc acc gga cac cca tca ttt gtc atg tcc 13l5Leu Leu Asn Leu Gly Asn Ala Thr Gly His Pro Ser Phe Val Met Ser390 395 400 405aac tct ttc gcc gat cag acc att gcg cag atc gaa ctg ttc caa aac 1363Asn Ser Phe Ala Asp Gln Thr Ile Ala Gln Ile Glu Leu Phe Gln Asn

410 415 420gaa gga cag tac gag aac gag gtc tac cgt ctg 1396Glu Gly Gln Tyr Glu Asn Glu Val Tyr Arg Leu

425430<210>224<211>432<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>224Met Ala Gln Val Met Asp Phe Lys Val Ala Asp Leu Ser Leu Ala Glu 151015 Ala Gly Arg His Gln Ile Arg Leu Ala Glu Tyr Glu Met Pro Gly Leu

20 25 30Met Gln Leu Arg Lys Glu Phe Ala Asp Glu Gln Pro Leu Lys Gly Ala

35 40 45Arg Ile Ala Gly Ser Ile His Met Thr Val Gln Thr Ala Val Leu Ile

50 55 60Glu Thr Leu Thr Ala Leu Gly Ala Glu Val Arg Trp Ala Ser Cys Asn 65 70 75 80Ile Phe Ser Thr Gln Asp Glu Ala Ala Ala Ala Ile Val Val Gly Ser

85 90 95Gly Thr Val Glu Glu Pro Ala Gly Val Pro Val Phe Ala Trp Lys Gly

100 105 110Glu Ser Leu Glu Glu Tyr Trp Trp Cys Ile Asn Gln Ile Phe Ser Trp

115 120 125Gly Asp Glu Leu Pro Asn Met Ile Leu Asp Asp Gly Gly Asp Ala Thr

130 135 140Met Ala Val Ile Arg Gly Arg Glu Tyr Glu Gln Ala Gly Leu Val Pro145 150 155 160Pro Ala Glu Ala Asn Asp Ser Asp Glu Tyr Ile Ala Phe Leu Gly Met

165 170 175Leu Arg Glu Val Leu Ala Ala Glu Pro Gly Lys Trp Gly Lys Ile Ala

180 185 190Glu Ala Val Lys Gly Val Thr Glu Glu Thr Thr Thr Gly Val His Arg

195 200 205Leu Tyr His Phe Ala Glu Glu Gly Val Leu Pro Phe Pro Ala Met Asn

210 215 220Val Asn Asp Ala Val Thr Lys Ser Lys Phe Asp Asn Lys Tyr Gly Thr225 230 235 240Arg His Ser Leu Ile Asp Gly Ile Asn Arg Ala Thr Asp Met Leu Met

245 250 255Gly Gly Lys Asn Val Leu Val Cys Gly Tyr Gly Asp Val Gly Lys Gly

260 265 270Cys Ala Glu Ala Phe Asp Gly Gln Gly Ala Arg Val Lys Val Thr Glu

275 280 285Ala Asp Pro Ile Asn Ala Leu Gln Ala Leu Met Asp Gly Tyr Ser Val

290 295 300Val Thr Val Asp Glu Ala Ile Glu Asp Ala Asp Ile Val Ile Thr Ala305 310 315 320Thr Gly Asn Lys Asp Ile Ile Ser Phe Glu Gln Met Leu Lys Met Lys

325 330 335Asp His Ala Leu Leu Gly Asn Ile Gly His Phe Asp Asn Glu Ile Asp

340345 350Met His Ser Leu Leu His Arg Asp Asp Val Thr Arg Thr Thr Ile Lys

355 360 365Pro Gln Val Asp Glu Phe Thr Phe Ser Thr Gly Arg Ser Ile Ile Val

370 375 380Leu Ser Glu Gly Arg Leu Leu Asn Leu Gly Asn Ala Thr Gly His Pro385 390 395 400Ser Phe Val Met Ser Asn Ser Phe Ala Asp Gln Thr Ile Ala Gln Ile

405 410 415Glu Leu Phe Gln Asn Glu Gly Gln Tyr Glu Asn Glu Val Tyr Arg Leu

420425430<210>225<211>2358<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (2335)<223>RXN02085<400>225cacccggtga tttcgcgaac cttgaaacat cgtcagaaga ttgccgtgcg tcctagccgg 60gatccgcacg ttcggctcaa gcagaaagtc tttaactcac atg act tcc aac ttt 115

Met Thr Ser Asn Phe

1 5tct tcc act gtc gct ggt ctt cct cgc atc gga gcg aag cgt gaa ctg 163Ser Ser Thr Val Ala Gly Leu Pro Arg Ile Gly Ala Lys Arg Glu Leu

10 15 20aag ttc gcg ctc gaa ggc tac tgg aat gga tca att gaa ggt cgc gaa 211Lys Phe Ala Leu Glu Gly Tyr Trp Asn Gly Ser Ile Glu Gly Arg Glu

25 30 35ctt gcg cag acc gcc cgc caa ttg gtc aac act gca tcg gat tct ttg 259Leu Ala Gln Thr Ala Arg Gln Leu Val Asn Thr Ala Ser Asp Ser Leu

40 45 50tct gga ttg gat tcc gtt ccg ttt gca gga cgt tcc tac tac gac gca 307Ser Gly Leu Asp Ser Val Pro Phe Ala Gly Arg Ser Tyr Tyr Asp Ala

55 60 65atg ctc gat acc gcc gct att ttg ggt gtg ctg ccg gag cgt ttt gat 355Met Leu Asp Thr Ala Ala Ile Leu Gly Val Leu Pro Glu Arg Phe Asp 70 75 80 85gac atc gct gat cat gaa aac gat ggt ctc cca ctg tgg att gac cgc 403Asp Ile Ala Asp His Glu Asn Asp Gly Leu Pro Leu Trp Ile Asp Arg

90 95 100tac ttt ggc gct gct cgc ggt act gag acc ctg cct gca cag gca atg 451Tyr Phe Gly Ala Ala Arg Gly Thr Glu Thr Leu Pro Ala Gln Ala Met

105 110 115acc aag tgg ttt gat acc aac tac cac tac ctc gtg ccg gag ttg tct 499Thr Lys Trp Phe Asp Thr Asn Tyr His Tyr Leu Val Pro Glu Leu Ser

120 125 130gcg gat aca cgt ttc gtt ttg gat gcg tcc gcg ctg att gag gat ctc 547Ala Asp Thr Arg Phe Val Leu Asp Ala Ser Ala Leu Ile Glu Asp Leu

135 140 145cgt tgc cag cag gtt cgt ggc gtt aat gcc cgc cct gtt ctg gtt ggt 595Arg Cys Gln Gln Val Arg Gly Val Asn Ala Arg Pro Val Leu Val Gly150 155 160 165cca ctg act ttc ctt tcc ctt gct cgc acc act gat ggt tcc aat cct 643Pro Leu Thr Phe Leu Ser Leu Ala Arg Thr Thr Asp Gly Ser Asn Pro

170 175 180ttg gat cac ctg cct gca ctg ttt gag gtc tac gag cgc ctc atc aag 691Leu Asp His Leu Pro Ala Leu Phe Glu Val Tyr Glu Arg Leu Ile Lys

185 190 195tct ttc gat act gag tgg gtt cag atc gat gag cct gcg ttg gtc acc 739Ser Phe Asp Thr Glu Trp Val Gln Ile Asp Glu Pro Ala Leu Val Thr

200 205 210gat gtt gct cct gag gtt ttg gagcag gtc cgc gct ggt tac acc act 787Asp Val Ala Pro Glu Val Leu Glu Gln Val Arg Ala Gly Tyr Thr Thr

215 220 225ttg gct aag cgc gat ggc gtg ttt gtc aat act tac ttc ggc tct ggc 835Leu Ala Lys Arg Asp Gly Val Phe Val Asn Thr Tyr Phe Gly Ser Gly230 235 240 245gat cag gcg ctg aac act ctt gcg ggc atc ggc ctt ggc gcg att ggc 883Asp Gln Ala Leu Asn Thr Leu Ala Gly Ile Gly Leu Gly Ala Ile Gly

250 255 260gtt gac ttg gtc acc cat ggc gtc act gag ctt gct gcg tgg aag ggt 931Val Asp Leu Val Thr His Gly Val Thr Glu Leu Ala Ala Trp Lys Gly

265 270 275gag gag ctg ctg gtt gcg ggc atc gtt gat ggt cgt aac att tgg cgc 979Glu Glu Leu Leu Val Ala Gly Ile Val Asp Gly Arg Asn Ile Trp Arg

280 285 290acc gac ctg tgt gct gct ctt gct tcc ctg aag cgc ctg gca gct cgc 1027Thr Asp Leu Cys Ala Ala Leu Ala Ser Leu Lys Arg Leu Ala Ala Arg

295 300 305ggc cca atc gca gtg tct acc tct tgt tca ctg ctg cac gtt cct tac 1075Gly Pro Ile Ala Val Ser Thr Ser Cys Ser Leu Leu His Val Pro Tyr310 315 320 325acc ctc gag gct gag aac att gag cct gag gtc cgc gac tgg ctt gcc 1123Thr Leu Glu Ala Glu Asn Ile Glu Pro Glu Val Arg Asp Trp Leu Ala

330 335 340ttc ggc tcg gag aag atc acc gag gtc aag ctg ctt gcc gac gcc cta 1171Phe Gly Ser Glu Lys Ile Thr Glu Val Lys Leu Leu Ala Asp Ala Leu

345 350 355gcc ggc aac atc gac gcg gct gcg ttc gat gcg gcg tcc gca gca att 1219Ala Gly Asn Ile Asp Ala Ala Ala Phe Asp Ala Ala Ser Ala Ala Ile

360 365 370gct tct cga cgc acc tcc cca cgc acc gca cca atc acg cag gaa ctc 1267Ala Ser Arg Arg Thr Ser Pro Arg Thr Ala Pro Ile Thr Gln Glu Leu

375 380 385cct ggc cgt agc cgt gga tcc ttc gac act cgt gtt acg ctg cag gag 1315Pro Gly Arg Ser Arg Gly Ser Phe Asp Thr Arg Val Thr Leu Gln Glu390 395 400 405aag tca ctg gag ctt cca gct ctg cca acc acc acc att ggt tct ttc 1363Lys Ser Leu Glu Leu Pro Ala Leu Pro Thr Thr Thr Ile Gly Ser Phe

410 415 420cca cag acc cca tcc att cgt tct gct cgc gct cgt ctg cgc aag gaa 1411Pro Gln Thr Pro Ser Ile Arg Ser Ala Arg Ala Arg Leu Arg Lys Glu

425 430 435tcc atc act ttg gag cag tac gaa gag gca atg cgc gaa gaa atc gat 1459Ser Ile Thr Leu Glu Gln Tyr Glu Glu Ala Met Arg Glu Glu Ile Asp

440 445 450ctg gtc atc gcc aag cag gaa gaa ctt ggt ctt gat gtg ttg gtt cac 1507Leu Val Ile Ala Lys Gln Glu Glu Leu Gly Leu Asp Val Leu Val His

455 460 465ggt gag cca gag cgc aac gac atg gtt cag tac ttc tct gaa ctt ctc 1555Gly Glu Pro Glu Arg Asn Asp Met Val Gln Tyr Phe Ser Glu Leu Leu470 475 480 485gac ggt ttc ctc tca acc gcc aac ggc tgg gtc caa agc tac ggc tcc 1603Asp Gly Phe Leu Ser Thr Ala Asn Gly Trp Val Gln Ser Tyr Gly Ser

490 495 500cgc tgt gtt cgt cct cca gtg ttg ttc gga aac gtt tcc cgc cca gcg 1651Arg Cys Val Arg Pro Pro Val Leu Phe Gly Asn Val Ser Arg Pro Ala

505 510 515cca atg act gtc aag tgg ttc cag tac gca cag agc ctg acc cag aag 1699Pro Met Thr Val Lys Trp Phe Gln Tyr Ala Gln Ser Leu Thr Gln Lys

520 525 530cat gtc aag gga atg ctc acc ggt cca gtc acc atc ctt gca tgg tcc 1747His Val Lys Gly Met Leu Thr Gly Pro Val Thr Ile Leu Ala Trp Ser

535 540 545ttc gtt cgc gat gat cag ccg ctg gct acc act gct gac cag gtt gca 1795Phe Val Arg Asp Asp Gln Pro Leu Ala Thr Thr Ala Asp Gln Val Ala550 555 560 565ctg gca ctg cgc gat gaa att aac gat ctc atc gag gct ggc gcg aag 1843Leu Ala Leu Arg Asp Glu Ile Asn Asp Leu Ile Glu Ala Gly Ala Lys

570 575 580atc atc cag gtg gat gag cct gcg att cgt gaa ctg ttg ccg cta cga 1891Ile Ile Gln Val Asp Glu Pro Ala Ile Arg Glu Leu Leu Pro Leu Arg

585 590 595gac gtc gat aag cot gcc tac ctg cag tgg tcc gtg gac tcc ttc cgc 1939Asp Val Asp Lys Pro Ala Tyr Leu Gln Trp Ser Val Asp Ser Phe Arg

600 605 610ctg gcg act gcc ggc gca ccc gac gac gtc caa atc cac acc cac atg 1987Leu Ala Thr Ala Gly Ala Pro Asp Asp Val Gln Ile His Thr His Met

615 620 625tgc tac tcc gag ttc aac gaa gtg atc tcc tcg gtc atc gcg ttg gat 2035Cys Tyr Ser Glu Phe Asn Glu Val Ile Ser Ser Val Ile Ala Leu Asp630 635 640 645gcc gat gtc acc acc atc gaa gca gca cgt tcc gac atg cag gtc ctc 2083Ala Asp Val Thr Thr Ile Glu Ala Ala Arg Ser Asp Met Gln Val Leu

650 655 660gct gct ctg aaa tct tcc ggc ttc gag ctc ggc gtc gga cct ggt gtg 2131Ala Ala Leu Lys Ser Ser Gly Phe Glu Leu Gly Val Gly Pro Gly Val

665 670 675tgg gat atc cac tcc ccg cgc gtt cct tcc gcg cag aaa gtg gac ggt 2179Trp Asp Ile His Ser Pro Arg Val Pro Ser Ala Gln Lys Val Asp Gly

680 685 690ctc ctc gag gct gca ctg cag tcc gtg gat cct cgc cag ctg tgg gtc 2227Leu Leu Glu Ala Ala Leu Gln Ser Val Asp Pro Arg Gln Leu Trp Val

695 700 705aac cca gac tgt ggt ctg aag acc cgt gga tgg cca gaa gtg gaa gct 2275Asn Pro Asp Cys Gly Leu Lys Thr Arg Gly Trp Pro Glu Val Glu Ala710 715 720 725tcc cta aag gtt ctc gtt gag tcc gct aag cag gct cgt gag aaa atc 2323Ser Leu Lys Val Leu Val Glu Ser Ala Lys Gln Ala Arg Glu Lys Ile

730 735 740gga gca act atc taaattgggt taccgctagg aac 2358Gly Ala Thr Ile

745<210>226<211>745<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>226Met Thr Ser Asn Phe Ser Ser Thr Val Ala Gly Leu Pro Arg Ile Gly 151015 Ala Lys Arg Glu Leu Lys Phe Ala Leu Glu Gly Tyr Trp Asn Gly Ser

20 25 30Ile Glu Gly Arg Glu Leu Ala Gln Thr Ala Arg Gln Leu Val Asn Thr

35 40 45Ala Ser Asp Ser Leu Ser Gly Leu Asp Ser Val Pro Phe Ala Gly Arg

50 55 60Ser Tyr Tyr Asp Ala Met Leu Asp Thr Ala Ala Ile Leu Gly Val Leu 65 70 75 80Pro Glu Arg Phe Asp Asp Ile Ala Asp His Glu Asn Asp Gly Leu Pro

85 90 95Leu Trp Ile Asp Arg Tyr Phe Gly Ala Ala Arg GlyThr Glu Thr Leu

100 105 110Pro Ala Gln Ala Met Thr Lys Trp Phe Asp Thr Asn Tyr His Tyr Leu

115 120 125Val Pro Glu Leu Ser Ala Asp Thr Arg Phe Val Leu Asp Ala Ser Ala

130 135 140Leu Ile Glu Asp Leu Arg Cys Gln Gln Val Arg Gly Val Asn Ala Arg145 150 155 160Pro Val Leu Val Gly Pro Leu Thr Phe Leu Ser Leu Ala Arg Thr Thr

165 170 175Asp Gly Ser Asn Pro Leu Asp His Leu Pro Ala Leu Phe Glu Val Tyr

180 185 190Glu Arg Leu Ile Lys Ser Phe Asp Thr Glu Trp Val Gln Ile Asp Glu

195 200 205Pro Ala Leu Val Thr Asp Val Ala Pro Glu Val Leu Glu Gln Val Arg

210 215 220Ala Gly Tyr Thr Thr Leu Ala Lys Arg Asp Gly Val Phe Val Asn Thr225 230 235 240Tyr Phe Gly Ser Gly Asp Gln Ala Leu Asn Thr Leu Ala Gly Ile Gly

245 250 255Leu Gly Ala Ile Gly Val Asp Leu Val Thr His Gly Val Thr Glu Leu

260 265 270Ala Ala Trp Lys Gly Glu Glu Leu Leu Val Ala Gly Ile Val Asp Gly

275 280 285Arg Asn Ile Trp Arg Thr Asp Leu Cys Ala Ala Leu Ala Ser Leu Lys

290 295 300Arg Leu Ala Ala Arg Gly Pro Ile Ala Val Ser Thr Ser Cys Ser Leu305 310 315 320Leu His Val Pro Tyr Thr Leu Glu Ala Glu Asn Ile Glu Pro Glu Val

325 330 335Arg Asp Trp Leu Ala Phe Gly Ser Glu Lys Ile Thr Glu Val Lys Leu

340 345 350Leu Ala Asp Ala Leu Ala Gly Asn Ile Asp Ala Ala Ala Phe Asp Ala

355 360 365Ala Ser Ala Ala Ile Ala Ser Arg Arg Thr Ser Pro Arg Thr Ala Pro

370 375 380Ile Thr Gln Glu Leu Pro Gly Arg Ser Arg Gly Ser Phe Asp Thr Arg385 390 395 400Val Thr Leu Gln Glu Lys Ser Leu Glu Leu Pro Ala Leu Pro Thr Thr

405 410 415Thr Ile Gly Ser Phe Pro Gln Thr Pro Ser Ile Arg Ser Ala Arg Ala

420 425 430Arg Leu Arg Lys Glu Ser Ile Thr Leu Glu Gln Tyr Glu Glu Ala Met

435 440 445Arg Glu Glu Ile Asp Leu Val Ile Ala Lys Gln Glu Glu Leu Gly Leu

450 455 460Asp Val Leu Val His Gly Glu Pro Glu Arg Asn Asp Met Val Gln Tyr465 470 475 480Phe Ser Glu Leu Leu Asp Gly Phe Leu Ser Thr Ala Asn Gly Trp Val

485 490 495Gln Ser Tyr Gly Ser Arg Cys Val Arg Pro Pro Val Leu Phe Gly Asn

500 505 510Val Ser Arg Pro Ala Pro Met Thr Val Lys Trp Phe Gln Tyr Ala Gln

515 520 525Ser Leu Thr Gln Lys His Val Lys Gly Met Leu Thr Gly Pro Val Thr

530 535 540Ile Leu Ala Trp Ser Phe Val Arg Asp Asp Gln Pro Leu Ala Thr Thr545550 555 560Ala Asp Gln Val Ala Leu Ala Leu Arg Asp Glu Ile Asn Asp Leu Ile

565 570 575Glu Ala Gly Ala Lys Ile Ile Gln Val Asp Glu Pro Ala Ile Arg Glu

580 585 590Leu Leu Pro Leu Arg Asp Val Asp Lys Pro Ala Tyr Leu Gln Trp Ser

595 600 605Val Asp Ser Phe Arg Leu Ala Thr Ala Gly Ala Pro Asp Asp Val Gln

610 615 620Ile His Thr His Met Cys Tyr Ser Glu Phe Asn Glu Val Ile Ser Ser625 630 635 640Val Ile Ala Leu Asp Ala Asp Val Thr Thr Ile Glu Ala Ala Arg Ser

645 650 655Asp Met Gln Val Leu Ala Ala Leu Lys Ser Ser Gly Phe Glu Leu Gly

660 665 670Val Gly Pro Gly Val Trp Asp Ile His Ser Pro Arg Val Pro Ser Ala

675 680 685Gln Lys Val Asp Gly Leu Leu Glu Ala Ala Leu Gln Ser Val Asp Pro

690 695 700Arg Gln Leu Trp Val Asn Pro Asp Cys Gly Leu Lys Thr Arg Gly Trp705 710 715 720Pro Glu Val Glu Ala Ser Leu Lys Val Leu Val Glu Ser Ala Lys Gln

725 730 735Ala Arg Glu Lys Ile Gly Ala Thr Ile

740745<210>227<211>1923<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1900)<223>FRXA02085<400>227cacccggtga tttcgcgaac cttgaaacat cgtcagaaga ttgccgtgcg tcctagccgg 60gatccgcacg ttcggctcaa gcagaaagtc tttaactcac atg act tcc aac ttt 115

Met Thr Ser Asn Phe

1 5tct tcc act gtc gct ggt ctt cct cgc atc gga gcg aag cgt gaa ctg 163Ser Ser Thr Val Ala Gly Leu Pro Arg Ile Gly Ala Lys Arg Glu Leu

10 15 20aag ttc gcg ctc gaa ggc tac tgg aat gga tca att gaa ggt cgc gaa 211Lys Phe Ala Leu Glu Gly Tyr Trp Asn Gly Ser Ile Glu Gly Arg Glu

25 30 35ctt gcg cag acc gcc cgc caa ttg gtc aac act gca tcg gat tct ttg 259Leu Ala Gln Thr Ala Arg Gln Leu Val Asn Thr Ala Ser Asp Ser Leu

40 45 50tct gga ttg gat tcc gtt ccg ttt gca gga cgt tcc tac tac gac gca 307Ser Gly Leu Asp Ser Val Pro Phe Ala Gly Arg Ser Tyr Tyr Asp Ala

55 60 65atg ctc gat acc gcc gct att ttg ggt gtg ctg ccg gag cgt ttt gat 355Met Leu Asp Thr Ala Ala Ile Leu Gly Val Leu Pro Glu Arg Phe Asp 70 75 80 85gac atc gct gat cat gaa aac gat ggt ctc cca ctg tgg att gac cgc 403Asp Ile Ala Asp His Glu Asn Asp Gly Leu Pro Leu Trp Ile Asp Arg

90 95 100tac ttt ggc gct gct cgc ggt act gag acc ctg cct gca cag gca atg 451Tyr Phe Gly Ala Ala Arg Gly Thr Glu Thr Leu Pro Ala Gln Ala Met

105 110 115acc aag tgg ttt gat acc aac tac cac tac ctc gtg ccg gag ttg tct 499Thr Lys Trp Phe Asp Thr Asn Tyr His Tyr Leu Val Pro Glu Leu Ser

120 125 130gcg gat aca cgt ttc gtt ttg gat gcg tcc gcg ctg att gag gat ctc 547Ala Asp Thr Arg Phe Val Leu Asp Ala Ser Ala Leu Ile Glu Asp Leu

135 140 145cgt tgc cag cag gtt cgt ggc gtt aat gcc cgc cct gtt ctg gtt ggt 595Arg Cys Gln Gln Val Arg Gly Val Asn Ala Arg Pro Val Leu Val Gly150 155 160 165cca ctg act ttc ctt tcc ctt gct cgc acc act gat ggt tcc aat cct 643Pro Leu Thr Phe Leu Ser Leu Ala Arg Thr Thr Asp Gly Ser Asn Pro

170 175 180ttg gat cac ctg cct gca ctg ttt gag gtc tac gag cgc ctc atc aag 691Leu Asp His Leu Pro Ala Leu Phe Glu Val Tyr Glu Arg Leu Ile Lys

185 190 195tct ttc gat act gag tgg gtt cag atc gat gag cct gcg ttg gtc acc 739Ser Phe Asp Thr Glu Trp Val Gln Ile Asp Glu Pro Ala Leu Val Thr

200 205 210gat gtt gct cct gag gtt ttg gag cag gtc cgc gct ggt tac acc act 787Asp Val Ala Pro Glu Val Leu Glu Gln Val Arg Ala Gly Tyr Thr Thr

215 220 225ttg gct aag cgc gat ggc gtg ttt gtc aat act tac ttc ggc tct ggc 835Leu Ala Lys Arg Asp Gly Val Phe Val Asn Thr Tyr Phe Gly Ser Gly230 235 240 245gat cag gcg ctg aac act ctt gcg ggc atc ggc ctt ggc gcg att ggc 883Asp Gln Ala Leu Asn Thr Leu Ala Gly Ile Gly Leu Gly Ala Ile Gly

250 255 260gtt gac ttg gtc acc cat ggc gtc act gag ctt gct gcg tgg aag ggt 931Val Asp Leu Val Thr His Gly Val Thr Glu Leu Ala Ala Trp Lys Gly

265 270 275gag gag ctg ctg gtt gcg ggc atc gtt gat ggt cgt aac att tgg cgc 979Glu Glu Leu Leu Val Ala Gly Ile Val Asp Gly Arg Asn Ile Trp Arg

280285 290acc gac ctg tgt gct gct ctt gct tcc ctg aag cgc ctg gca gct cgc 1027Thr Asp Leu Cys Ala Ala Leu Ala Ser Leu Lys Arg Leu Ala Ala Arg

295 300 305ggc cca atc gca gtg tct acc tct tgt tca ctg ctg cac gtt cct tac 1075Gly Pro Ile Ala Val Ser Thr Ser Cys Ser Leu Leu His Val Pro Tyr310 315 320 325acc ctc gag gct gag aac att gag cct gag gtc cgc gac tgg ctt gcc 1123Thr Leu Glu Ala Glu Asn Ile Glu Pro Glu Val Arg Asp Trp Leu Ala

330 335 340ttc ggc tcg gag aag atc acc gag gtc aag ctg ctt gcc gac gcc cta 1171Phe Gly Ser Glu Lys Ile Thr Glu Val Lys Leu Leu Ala Asp Ala Leu

345 350 355gcc ggc aac atc gac gcg gct gcg ttc gat gcg gcg tcc gca gca att 1219Ala Gly Asn Ile Asp Ala Ala Ala Phe Asp Ala Ala Ser Ala Ala Ile

360 365 370gct tct cga cgc acc tcc cca cgc acc gca cca atc acg cag gaa ctc 1267Ala Ser Arg Arg Thr Ser Pro Arg Thr Ala Pro Ile Thr Gln Glu Leu

375 380 385cct ggc cgt agc cgt gga tcc ttc gac act cgt gtt acg ctg cag gag 1315Pro Gly Arg Ser Arg Gly Ser Phe Asp Thr Arg Val Thr Leu Gln Glu390 395 400 405aag tca ctg gag ctt cca gct ctg cca acc acc acc att ggt tct ttc 1363Lys Ser Leu Glu Leu Pro Ala Leu Pro Thr Thr Thr Ile Gly Ser Phe

410 415 420cca cag acc cca tcc att cgt tct gct cgc gct cgt ctg cgc aag gaa 1411Pro Gln Thr Pro Ser Ile Arg Ser Ala Arg Ala Arg Leu Arg Lys Glu

425 430 435tcc atc act ttg gag cag tac gaa gag gca atg cgc gaa gaa atc gat 1459Ser Ile Thr Leu Glu Gln Tyr Glu Glu Ala Met Arg Glu Glu Ile Asp

440 445 450ctg gtc atc gcc aag cag gaa gaa ctt ggt ctt gat gtg ttg gtt cac 1507Leu Val Ile Ala Lys Gln Glu Glu Leu Gly Leu Asp Val Leu Val His

455 460 465ggt gag cca gag cgc aac gac atg gtt cag tac ttc tct gaa ctt ctc 1555Gly Glu Pro Glu Arg Asn Asp Met Val Gln Tyr Phe Ser Glu Leu Leu470 475 480 485gac ggt ttc ctc tca acc gcc aac ggc tgg gtc caa agc tac ggc tcc 1603Asp Gly Phe Leu Ser Thr Ala Asn Gly Trp Val Gln Ser Tyr Gly Ser

490 495 500cgc tgt gtt cgt cct cca gtg ttg ttc gga aac gtt tcc cgc cca gcg 1651Arg Cys Val Arg Pro Pro Val Leu Phe Gly Asn Val Ser Arg Pro Ala

505 510 515cca atg act gtc aag tgg ttc cag tac gca cag agc ctg acc cag aag 1699Pro Met Thr Val Lys Trp Phe Gln Tyr Ala Gln Ser Leu Thr Gln Lys

520 525 530cat gtc aag gga atg ctc acc ggt cca gtc acc atc ctt gca tgg tcc 1747His Val Lys Gly Met Leu Thr Gly Pro Val Thr Ile Leu Ala Trp Ser

535 540 545ttc gtt cgc gat gat cag ccg ctg gct acc act gct gac cag gtt gca 1795Phe Val Arg Asp Asp Gln Pro Leu Ala Thr Thr Ala Asp Gln Val Ala550 555 560 565ctg gca ctg cgc gat gaa att aac gat ctc atc gag gct ggc gcg aag 1843Leu Ala Leu Arg Asp Glu Ile Asn Asp Leu Ile Glu Ala Gly Ala Lys

570 575 580atc atc cag gtg gat gag cct gcg att cgt gaa ctg ttg ccc gct acg 1891Ile Ile Gln Val Asp Glu Pro Ala Ile Arg Glu Leu Leu Pro Ala Thr

585 590595aga cgt cga taagcctgcc tacctgcagt ggt 1923Arg Arg Arg

600<210>228<211>600<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>228Met Thr Ser Asn Phe Ser Ser Thr Val Ala Gly Leu Pro Arg Ile Gly 151015 Ala Lys Arg Glu Leu Lys Phe Ala Leu Glu Gly Tyr Trp Asn Gly Ser

20 25 30Ile Glu Gly Arg Glu Leu Ala Gln Thr Ala Arg Gln Leu Val Asn Thr

35 40 45Ala Ser Asp Ser Leu Ser Gly Leu Asp Ser Val Pro Phe Ala Gly Arg

50 55 60Ser Tyr Tyr Asp Ala Met Leu Asp Thr Ala Ala Ile Leu Gly Val Leu 65 70 75 80Pro Glu Arg Phe Asp Asp Ile Ala Asp His Glu Asn Asp Gly Leu Pro

85 90 95Leu Trp Ile Asp Arg Tyr Phe Gly Ala Ala Arg Gly Thr Glu Thr Leu

100 105 110Pro Ala Gln Ala Met Thr Lys Trp Phe Asp Thr Asn Tyr His Tyr Leu

115 120 125Val Pro Glu Leu Ser Ala Asp Thr Arg Phe Val Leu Asp Ala Ser Ala

130 135 140Leu Ile Glu Asp Leu Arg Cys Gln Gln Val Arg Gly Val Asn Ala Arg145 150 155 160Pro Val Leu Val Gly Pro Leu Thr Phe Leu Ser Leu Ala Arg Thr Thr

165 170 175Asp Gly Ser Asn Pro Leu Asp His Leu Pro Ala Leu Phe Glu Val Tyr

180 185 190Glu Arg Leu Ile Lys Ser Phe Asp Thr Glu Trp Val Gln Ile Asp Glu

195 200 205Pro Ala Leu Val Thr Asp Val Ala Pro Glu Val Leu Glu Gln Val Arg

210 215 220Ala Gly Tyr Thr Thr Leu Ala Lys Arg Asp Gly Val Phe Val Asn Thr225 230 235 240Tyr Phe Gly Ser Gly Asp Gln Ala Leu Asn Thr Leu Ala Gly Ile Gly

245 250 255Leu Gly Ala Ile Gly Val Asp Leu Val Thr His Gly Val Thr Glu Leu

260 265 270Ala Ala Trp Lys Gly Glu Glu Leu Leu Val Ala Gly Ile Val Asp Gly

275 280 285Arg Asn Ile Trp Arg Thr Asp Leu Cys Ala Ala Leu Ala Ser Leu Lys

290 295 300Arg Leu Ala Ala Arg Gly Pro Ile Ala Val Ser Thr Ser Cys Ser Leu305 310 315 320Leu His Val Pro Tyr Thr Leu Glu Ala Glu Asn Ile Glu Pro Glu Val

325 330 335Arg Asp Trp Leu Ala Phe Gly Ser Glu Lys Ile Thr Glu Val Lys Leu

340 345 350Leu Ala Asp Ala Leu Ala Gly Asn Ile Asp Ala Ala Ala Phe Asp Ala

355 360 365Ala Ser Ala Ala Ile Ala Ser Arg Arg Thr Ser Pro Arg Thr Ala Pro

370 375 380Ile Thr Gln Glu Leu Pro Gly Arg Ser Arg Gly Ser Phe Asp Thr Arg385 390 395 400Val Thr Leu Gln Glu Lys Ser Leu Glu Leu Pro Ala Leu Pro Thr Thr

405 410 415Thr Ile Gly Ser Phe Pro Gln Thr Pro Ser Ile Arg Ser Ala Arg Ala

420 425 430Arg Leu Arg Lys Glu Ser Ile Thr Leu Glu Gln Tyr Glu Glu Ala Met

435 440 445Arg Glu Glu Ile Asp Leu Val Ile Ala Lys Gln Glu Glu Leu Gly Leu

450 455 460Asp Val Leu Val His Gly Glu Pro Glu Arg Asn Asp Met Val Gln Tyr465 470 475 480Phe Ser Glu Leu Leu Asp Gly Phe Leu Ser Thr Ala Asn Gly Trp Val

485 490 495Gln Ser Tyr Gly Ser Arg Cys Val Arg Pro Pro Val Leu Phe Gly Asn

500 505 510Val Ser Arg Pro Ala Pro Met Thr Val Lys Trp Phe Gln Tyr Ala Gln

515 520 525Ser Leu Thr Gln Lys His Val Lys Gly Met Leu Thr Gly Pro Val Thr

530 535 540Ile Leu Ala Trp Ser Phe Val Arg Asp Asp Gln Pro Leu Ala Thr Thr545 550 555 560Ala Asp Gln Val Ala Leu Ala Leu Arg Asp Glu Ile Asn Asp Leu Ile

565 570 575Glu Ala Gly Ala Lys Ile Ile Gln Val Asp Glu Pro Ala Ile Arg Glu

580 585 590Leu Leu Pro Ala Thr Arg Arg Arg

595600<210>229<211>603<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (580)<223>FRXA02086<400>229gatgatcagc cgctggctac cactgctgac caggttgcac tggcactgcg cgatgaaatt 60aacgatctca tcgaggctgg cgcgaagatc atccaggtgg atg agc ctg cga ttc 115

Met Ser Leu Arg Phe

1 5gtg aac tgt tgc ccg cta cga gac gtc gat aag cct gcc tac ctg cag 163Val Asn Cys Cys Pro Leu Arg Asp Val Asp Lys Pro Ala Tyr Leu Gln

10 15 20tgg tcc gtg gac tcc ttc cgc ctg gcg act gcc ggc gca ccc gac gac 211Trp Ser Val Asp Ser Phe Arg Leu Ala Thr Ala Gly Ala Pro Asp Asp

25 30 35gtc caa atc cac acc cac atg tgc tac tcc gag ttc aac gaa gtg atc 259Val Gln Ile His Thr His Met Cys Tyr Ser Glu Phe Asn Glu Val Ile

40 45 50tcc tcg gtc atc gcg ttg gat gcc gat gtc acc acc atc gaa gca gca 307Ser Ser Val Ile Ala Leu Asp Ala Asp Val Thr Thr Ile Glu Ala Ala

55 60 65cgt tcc gac atg cag gtc ctc gct gct ctg aaa tct tcc ggc ttc gag 355Arg Ser Asp Met Gln Val Leu Ala Ala Leu Lys Ser Ser Gly Phe Glu 70 75 80 85ctc ggc gtc gga cct ggt gtg tgg gat atc cac tcc ccg cgc gtt cct 403Leu Gly Val Gly Pro Gly Val Trp Asp Ile His Ser Pro Arg Val Pro

90 95 100tcc gcg cag aaa gtg gac ggt ctc ctc gag gct gca ctg cag tcc gtg 451Ser Ala Gln Lys Val Asp Gly Leu Leu Glu Ala Ala Leu Gln Ser Val

105 110 115gat cct cgc cag ctg tgg gtc aac cca gac tgt ggt ctg aag acc cgt 499Asp Pro Arg Gln Leu Trp Val Asn Pro Asp Cys Gly Leu Lys Thr Arg

120 125 130gga tgg cca gaa gtg gaa gct tcc cta aag gtt ctc gtt gag tcc gct 547Gly Trp Pro Glu Val Glu Ala Ser Leu Lys Val Leu Val Glu Ser Ala

135140145 aag cag gct cgt gag aaa atc gga gca act atctaaattgggt taccgctagg 600Lys Gln Ala Arg Glu Lys Ile Gly Ala Thr Ile 150155160 aac 603<210>230<211>160<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>230Met Ser Leu Arg Phe Val Asn Cys Cys Pro Leu Arg Asp Val Asp Lys 151015 Pro Ala Tyr Leu Gln Trp Ser Val Asp Ser Phe Arg Leu Ala Thr Ala

20 25 30Gly Ala Pro Asp Asp Val Gln Ile His Thr His Met Cys Tyr Ser Glu

35 40 45Phe Asn Glu Val Ile Ser Ser Val Ile Ala Leu Asp Ala Asp Val Thr

50 55 60Thr Ile Glu Ala Ala Arg Ser Asp Met Gln Val Leu Ala Ala Leu Lys 65 70 75 80Ser Ser Gly Phe Glu Leu Gly Val Gly Pro Gly Val Trp Asp Ile His

85 90 95Ser Pro Arg Val Pro Ser Ala Gln Lys Val Asp Gly Leu Leu Glu Ala

100 105 110Ala Leu Gln Ser Val Asp Pro Arg Gln Leu Trp Val Asn Pro Asp Cys

115 120 125Gly Leu Lys Thr Arg Gly Trp Pro Glu Val Glu Ala Ser Leu Lys Val

130135140 Leu Val Glu Ser Ala Lys Gln Ala Arg Glu Lys Ile Gly Ala Thr Ile 145150155160<210>231<211>1326<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1303)<223>RXN02648<400>231atgaataaaa ttccgggtgc agtgaccgta ggtgaggtaa acgcggttag agtcgaatga 60gagtttgata ctttctttcg acttttagat tggattttca atg agc cag aac cgc 115

Met Ser Gln Asn Arg

1 5atc agg accact cac gtt ggt tcc ttg ccc cgt acc cca gag cta ctt 163Ile Arg Thr Thr His Val Gly Ser Leu Pro Arg Thr Pro Glu Leu Leu

10 15 20gat gca aac atc aag cgt tct aac ggt gag att ggg gag gag gaa ttc 211Asp Ala Asn Ile Lys Arg Ser Asn Gly Glu Ile Gly Glu Glu Glu Phe

25 30 35ttc cag att ctg cag tct tct gta gat gac gtg atc aag cgc cag gtt 259Phe Gln Ile Leu Gln Ser Ser Val Asp Asp Val Ile Lys Arg Gln Val

40 45 50gac ctg ggt atc gac atc ctt aac gag ggc gaa tac ggc cac gtc acc 307Asp Leu Gly Ile Asp Ile Leu Asn Glu Gly Glu Tyr Gly His Val Thr

55 60 65tcc ggt gca gtt gac ttc ggt gca tgg tgg aac tac tcc ttc acc cgc 355Ser Gly Ala Val Asp Phe Gly Ala Trp Trp Asn Tyr Ser Phe Thr Arg 70 75 80 85ctg ggc gga ctg acc atg acc gat acc gac cgt tgg gca agc cag gaa 403Leu Gly Gly Leu Thr Met Thr Asp Thr Asp Arg Trp Ala Ser Gln Glu

90 95 100gca gtg cgt tcc acc cct ggc aac atc gag ctg acc agc ttc tct gat 451Ala Val Arg Ser Thr Pro Gly Asn Ile Glu Leu Thr Ser Phe Ser Asp

105 110 115cgt cgc gac cgc gca ttg ttc agc gaa gca tac gag gat cca gta tct 499Arg Arg Asp Arg Ala Leu Phe Ser Glu Ala Tyr Glu Asp Pro Val Ser

120 125 130ggc atc ttc acc ggt cgc gct tct gtg ggc aac cca gag ttc acc gga 547Gly Ile Phe Thr Gly Arg Ala Ser Val Gly Asn Pro Glu Phe Thr Gly

135 140 145cct att acc tac att ggc cag gaa gaa act cag acg gat gtt gat ctg 595Pro Ile Thr Tyr Ile Gly Gln Glu Glu Thr Gln Thr Asp Val Asp Leu150 155 160 165ctg aag aag ggc atg aac gca gcg gga gct acc gac ggc ttc gtt gca 643Leu Lys Lys Gly Met Asn Ala Ala Gly Ala Thr Asp Gly Phe Val Ala

170 175 180gca cta tcc cca gga tct gca gct cga ttg acc aac aag ttc tac gac 691Ala Leu Ser Pro Gly Ser Ala Ala Arg Leu Thr Asn Lys Phe Tyr Asp

185 190 195act gat gaa gaa gtc gtc gca gca tgt gct gat gcg ctt tcc cag gaa 739Thr Asp Glu Glu Val Val Ala Ala Cys Ala Asp Ala Leu Ser Gln Glu

200 205 210tac aag atc atc acc gat gca ggt ctg acc gtt cag ctc gac gca ccg 787Tyr Lys Ile Ile Thr Asp Ala Gly Leu Thr Val Gln Leu Asp Ala Pro

215 220 225gac ttg gca gaa gca tgg gat cag atc aac cca gag cca agc gtg aag 835Asp Leu Ala Glu Ala Trp Asp Gln Ile Asn Pro Glu Pro Ser Val Lys230 235 240 245gat tac ttg gac tgg atc ggt aca cgc atc gat gcc atc aac agt gca 883Asp Tyr Leu Asp Trp Ile Gly Thr Arg Ile Asp Ala Ile Asn Ser Ala

250 255 260gtg aag ggc ctt cca aag gaa cag acc cgc ctg cac atc tgc tgg ggc 931Val Lys Gly Leu Pro Lys Glu Gln Thr Arg Leu His Ile Cys Trp Gly

265 270 275tct tgg cac gga cca cac gtc act gac atc cca ttc ggt gac atc att 979Ser Trp His Gly Pro His Val Thr Asp Ile Pro Phe Gly Asp Ile Ile

280 285 290ggt gag atc ctg cgc gca gag gtc ggt ggc ttc tcc ttc gaa ggc gca 1027Gly Glu Ile Leu Arg Ala Glu Val Gly Gly Phe Ser Phe Glu Gly Ala

295 300305tct cct cgt cac gca cac gag tgg cgt gta tgg gaa gaa aac aag ctt 1075Ser Pro Arg His Ala His Glu Trp Arg Val Trp Glu Glu Asn Lys Leu310 315 320 325cct gaa ggc tct gtt atc tac cct ggt gtt gtg tct cac tcc atc aac 1123Pro Glu Gly Ser Val Ile Tyr Pro Gly Val Val Ser His Ser Ile Asn

330 335 340gct gtg gag cac cca cgc ctg gtt gct gat cgt atc gtt cag ttc gcc 1171Ala Val Glu His Pro Arg Leu Val Ala Asp Arg Ile Val Gln Phe Ala

345 350 355aag ctt gtt ggc cct gag aac gtc att gcg tcc act gac tgt ggt ctg 1219Lys Leu Val Gly Pro Glu Asn Val Ile Ala Ser Thr Asp Cys Gly Leu

360 365 370ggc gga cgt ctg cat tcc cag atc gca tgg gca aag ctg gag tcc cta 1267Gly Gly Arg Leu His Ser Gln Ile Ala Trp Ala Lys Leu Glu Ser Leu

375380385 gta gag ggc gct cgc att gca tca aag gaa ctg ttc taagctagac 1313Val Glu Gly Ala Arg Ile Ala Ser Lys Glu Leu Phe 390395400 aacgagggttt gct 1326<210>232<211>401<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>232Met Ser Gln Asn Arg Ile Arg Thr Thr His Val Gly Ser Leu Pro Arg 151015 Thr Pro Glu Leu Leu Asp Ala Asn Ile Lys Arg Ser Asn Gly Glu Ile

20 25 30Gly Glu Glu Glu Phe Phe Gln Ile Leu Gln Ser Ser Val Asp Asp Val

35 40 45Ile Lys Arg Gln Val Asp Leu Gly Ile Asp Ile Leu Asn Glu Gly Glu

50 55 60Tyr Gly His Val Thr Ser Gly Ala Val Asp Phe Gly Ala Trp Trp Asn 65 70 75 80Tyr Ser Phe Thr Arg Leu Gly Gly Leu Thr Met Thr Asp Thr Asp Arg

85 90 95Trp Ala Ser Gln Glu Ala Val Arg Ser Thr Pro Gly Asn Ile Glu Leu

100 105 110Thr Ser Phe Ser Asp Arg Arg Asp Arg Ala Leu Phe Ser Glu Ala Tyr

115 120 125Glu Asp Pro Val Ser Gly Ile Phe Thr Gly Arg Ala Ser Val Gly Asn

130 135 140Pro Glu Phe Thr Gly Pro Ile Thr Tyr Ile Gly Gln Glu Glu Thr Gln145 150 155 160Thr Asp Val Asp Leu Leu Lys Lys Gly Met Asn Ala Ala Gly Ala Thr

165 170 175Asp Gly Phe Val Ala Ala Leu Ser Pro Gly Ser Ala Ala Arg Leu Thr

180 185 190Asn Lys Phe Tyr Asp Thr Asp Glu Glu Val Val Ala Ala Cys Ala Asp

195 200 205Ala Leu Ser Gln Glu Tyr Lys Ile Ile Thr Asp Ala Gly Leu Thr Val

210 215 220Gln Leu Asp Ala Pro Asp Leu Ala Glu Ala Trp Asp Gln Ile Asn Pro225 230 235 240Glu Pro Ser Val Lys Asp Tyr Leu Asp Trp Ile Gly Thr Arg Ile Asp

245 250 255Ala Ile Asn Ser Ala Val Lys Gly Leu Pro Lys Glu Gln Thr Arg Leu

260 265 270His Ile Cys Trp Gly Ser Trp His Gly Pro His Val Thr Asp Ile Pro

275 280 285Phe Gly Asp Ile Ile Gly Glu Ile Leu Arg Ala Glu Val Gly Gly Phe

290 295 300Ser Phe Glu Gly Ala Ser Pro Arg His Ala His Glu Trp Arg Val Trp305 310 315 320Glu Glu Asn Lys Leu Pro Glu Gly Ser Val Ile Tyr Pro Gly Val Val

325 330 335Ser His Ser Ile Asn Ala Val Glu His Pro Arg Leu Val Ala Asp Arg

340 345 350Ile Val Gln Phe Ala Lys Leu Val Gly Pro Glu Asn Val Ile Ala Ser

355 360 365Thr Asp Cys Gly Leu Gly Gly Arg Leu His Ser Gln Ile Ala Trp Ala

370375380 Lys Leu Glu Ser Leu Val Glu Gly Ala Arg Ile Ala Ser Lys Glu Leu 385390395400 Phe<210>233<211>548<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (525)<223>FRXA02648<400>233gac gca ccg gac ttg gca gaa gca tgg gat cag atc aac cca gag cca 48Asp Ala Pro Asp Leu Ala Glu Ala Trp Asp Gln Ile Asn Pro Glu Pro 151015 agc gtg aag gat tac ttg gac tgg atc ggt aca cgc atc gat gcc atc 96Ser Val Lys Asp Tyr Leu Asp Trp Ile Gly Thr Arg Ile Asp Ala Ile

20 25 30aac agt gca gtg aag ggc ctt cca aag gaa cag acc cgc ctg cac atc 144Asn Ser Ala Val Lys Gly Leu Pro Lys Glu Gln Thr Arg Leu His Ile

35 40 45tgc tgg ggc tct tgg cac gga cca cac gtc act gac atc cca ttc ggt 192Cys Trp Gly Ser Trp His Gly Pro His Val Thr Asp Ile Pro Phe Gly

50 55 60gac atc att ggt gag atc ctg cgc gca gag gtc ggt ggc ttc tcc ttc 240Asp Ile Ile Gly Glu Ile Leu Arg Ala Glu Val Gly Gly Phe Ser Phe 65 70 75 80gaa ggc gca tct cct cgt cac gca cac gag tgg cgt gta tgg gaa gaa 288Glu Gly Ala Ser Pro Arg His Ala His Glu Trp Arg Val Trp Glu Glu

85 90 95aac aag ctt cct gaa ggc tct gtt atc tac cct ggt gtt gtg tct cac 336Asn Lys Leu Pro Glu Gly Ser Val Ile Tyr Pro Gly Val Val Ser His

100 105 110tcc atc aac gct gtg gag cac cca cgc ctg gtt gct gat cgt atc gtt 384Ser Ile Asn Ala Val Glu His Pro Arg Leu Val Ala Asp Arg Ile Val

115 120 125cag ttc gcc aag ctt gtt ggc cct gag aac gtc att gcg tcc act gac 432Gln Phe Ala Lys Leu Val Gly Pro Glu Asn Val Ile Ala Ser Thr Asp

130 135 140tgt ggt ctg ggc gga cgt ctg cat tcc cag atc gca tgg gca aag ctg 480Cys Gly Leu Gly Gly Arg Leu His Ser Gln Ile Ala Trp Ala Lys Leu145 150 155 160gag tcc cta gta gag ggc gct cgc att gca tca aag gaa ctg ttc 525Glu Ser Leu Val Glu Gly Ala Arg Ile Ala Ser Lys Glu Leu Phe

165170175 taagctagac aacgagggtt gct 548<210>234<211>175<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>234Asp Ala Pro Asp Leu Ala Glu Ala Trp Asp Gln Ile Asn Pro Glu Pro 151015 Ser Val Lys Asp Tyr Leu Asp Trp Ile Gly Thr Arg Ile Asp Ala Ile

20 25 30Asn Ser Ala Val Lys Gly Leu Pro Lys Glu Gln Thr Arg Leu His Ile

35 40 45Cys Trp Gly Ser Trp His Gly Pro His Val Thr Asp Ile Pro Phe Gly

50 55 60Asp Ile Ile Gly Glu Ile Leu Arg Ala Glu Val Gly Gly Phe Ser Phe 65 70 75 80Glu Gly Ala Ser Pro Arg His Ala His Glu Trp Arg Val Trp Glu Glu

85 9095Asn Lys Leu Pro Glu Gly Ser Val Ile Tyr Pro Gly Val Val Ser His

100 105 110Ser Ile Asn Ala Val Glu His Pro Arg Leu Val Ala Asp Arg Ile Val

115 120 125Gln Phe Ala Lys Leu Val Gly Pro Glu Asn Val Ile Ala Ser Thr Asp

130 135 140Cys Gly Leu Gly Gly Arg Leu His Ser Gln Ile Ala Trp Ala Lys Leu145 150 155 160Glu Ser Leu Val Glu Gly Ala Arg Ile Ala Ser Lys Glu Leu Phe

165170175<210>235<211>784<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (784)<223>FRXA02658<400>235atgaataaaa ttccgggtgc agtgaccgta ggtgaggtaa acgcggttag agtcgaatga 60gagtttgata ctttctttcg acttttagat tggattttca atg agc cag aac cgc 115

Met Ser Gln Asn Arg

1 5atc agg acc act cac gtt ggt tcc ttg ccc cgt acc cca gag cta ctt 163Ile Arg Thr Thr His Val Gly Ser Leu Pro Arg Thr Pro Glu Leu Leu

10 15 20gat gca aac atc aag cgt tct aac ggt gag att ggg gag gag gaa ttc 211Asp Ala Asn Ile Lys Arg Ser Asn Gly Glu Ile Gly Glu Glu Glu Phe

25 30 35ttc cag att ctg cag tct tct gta gat gac gtg atc aag cgc cag gtt 259Phe Gln Ile Leu Gln Ser Ser Val Asp Asp Val Ile Lys Arg Gln Val

40 45 50gac ctg ggt atc gac atc ctt aac gag ggc gaa tac ggc cac gtc acc 307Asp Leu Gly Ile Asp Ile Leu Asn Glu Gly Glu Tyr Gly His Val Thr

55 60 65tcc ggt gca gtt gac ttc ggt gca tgg tgg aac tac tcc ttc acc cgc 355Ser Gly Ala Val Asp Phe Gly Ala Trp Trp Asn Tyr Ser Phe Thr Arg 70 75 80 85ctg ggc gga ctg acc atg acc gat acc gac cgt tgg gca agc cag gaa 403Leu Gly Gly Leu Thr Met Thr Asp Thr Asp Arg Trp Ala Ser Gln Glu

90 95 100gca gtg cgt tcc acc cct ggc aac atc gag ctg acc agc ttc tct gat 451Ala Val Arg Ser Thr Pro Gly Asn Ile Glu Leu Thr Ser Phe Ser Asp

105 110 115

cgt cgc gac cgc gca ttg ttc agc gaa gca tac gag gat cca gta tct 499Arg Arg Asp Arg Ala Leu Phe Ser Glu Ala Tyr Glu Asp Pro Val Ser

120 125 130ggc atc ttc acc ggt cgc gct tct gtg ggc aac cca gag ttc acc gga 547Gly Ile Phe Thr Gly Arg Ala Ser Val Gly Asn Pro Glu Phe Thr Gly

135 140 145cct att acc tac att ggc cag gaa gaa act cag acg gat gtt gat ctg 595Pro Ile Thr Tyr Ile Gly Gln Glu Glu Thr Gln Thr Asp Val Asp Leu150 155 160 165ctg aag aag ggc atg aac gca gcg gga gct acc gac ggc ttc gtt gca 643Leu Lys Lys Gly Met Asn Ala Ala Gly Ala Thr Asp Gly Phe Val Ala

170 175 180gca cta tcc cca gga tct gca gct cga ttg acc aac aag ttc tac gac 691Ala Leu Ser Pro Gly Ser Ala Ala Arg Leu Thr Asn Lys Phe Tyr Asp

185 190 195act gat gaa gaa gtc gtc gca gca tgt gct gat gcg ctt tcc cag gaa 739Thr Asp Glu Glu Val Val Ala Ala Cys Ala Asp Ala Leu Ser Gln Glu

200 205 210tac aag atc atc acc gat gca ggt ctg acc gtt cag ctc gac gca 784Tyr Lys Ile Ile Thr Asp Ala Gly Leu Thr Val Gln Leu Asp Ala

215220225<210>236<211>228<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>236Met Ser Gln Asn Arg Ile Arg Thr Thr His Val Gly Ser Leu Pro Arg 151015 Thr Pro Glu Leu Leu Asp Ala Asn Ile Lys Arg Ser Asn Gly Glu Ile

20 25 30Gly Glu Glu Glu Phe Phe Gln Ile Leu Gln Ser Ser Val Asp Asp Val

35 40 45Ile Lys Arg Gln Val Asp Leu Gly Ile Asp Ile Leu Asn Glu Gly Glu

50 55 60Tyr Gly His Val Thr Ser Gly Ala Val Asp Phe Gly Ala Trp Trp Asn 65 70 75 80Tyr Ser Phe Thr Arg Leu Gly Gly Leu Thr Met Thr Asp Thr Asp Arg

85 90 95Trp Ala Ser Gln Glu Ala Val Arg Ser Thr Pro Gly Asn Ile Glu Leu

100 105 110Thr Ser Phe Ser Asp Arg Arg Asp Arg Ala Leu Phe Ser Glu Ala Tyr

115 120 125Glu Asp Pro Val Ser Gly Ile Phe Thr Gly Arg Ala Ser Val Gly Asn

130 135 140Pro Glu Phe Thr Gly Pro Ile Thr Tyr Ile Gly Gln Glu Glu Thr Gln145 150 155 160Thr Asp Val Asp Leu Leu Lys Lys Gly Met Asn Ala Ala Gly Ala Thr

165 170 175Asp Gly Phe Val Ala Ala Leu Ser Pro Gly Ser Ala Ala Arg Leu Thr

180 185 190Asn Lys Phe Tyr Asp Thr Asp Glu Glu Val Val Ala Ala Cys Ala Asp

195 200 205Ala Leu Ser Gln Glu Tyr Lys Ile Ile Thr Asp Ala Gly Leu Thr Val

210215220 Gln Leu Asp Ala225<210>237<211>408<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (385)<223>RXC02238<400>237ggcgcttagc caaaacatag agcggtaggg tatgcttatc cgattgagca acctttcccg 60ctcttaacac tactgtccat atacttttga aaaggtgtca gtg acc aac gtg agc 115

Val Thr Asn Val Ser

1 5aac gag acc aac gcc acc aag gcc gtc ttc gat ccg cca gtg ggc att 163Asn Glu Thr Asn Ala Thr Lys Ala Val Phe Asp Pro Pro Val Gly Ile

10 15 20acc gct cct ccg atc gat gaa ctg ctg gat aag gtc act tcc aag tac 211Thr Ala Pro Pro Ile Asp Glu Leu Leu Asp Lys Val Thr Ser Lys Tyr

25 30 35gcc ctc gtg atc ttc gca gcc aag cgt gcg cgc cag atc aac agc ttc 259Ala Leu Val Ile Phe Ala Ala Lys Arg Ala Arg Gln Ile Asn Ser Phe

40 45 50tac cat cag gca gat gag gga gta ttc gag ttc atc gga cca ttg gtt 307Tyr His Gln Ala Asp Glu Gly Val Phe Glu Phe Ile Gly Pro Leu Val

55 60 65act ccg cag cca ggc gaa aag cca ctt tct att gct ctg cgt gag atc 355Thr Pro Gln Pro Gly Glu Lys Pro Leu Ser Ile Ala Leu Arg Glu Ile 70 75 80 85aat gca ggt ctg ttg gac cac gag gaa ggt taaaagacct tataacttca 405Asn Ala Gly Leu Leu Asp His Glu Glu Gly

9095 cac 408<210>238<211>95<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>238Val Thr Asn Val Ser Asn Glu Thr Asn Ala Thr Lys Ala Val Phe Asp 151015 Pro Pro Val Gly Ile Thr Ala Pro Pro Ile Asp Glu Leu Leu Asp Lys

20 25 30Val Thr Ser Lys Tyr Ala Leu Val Ile Phe Ala Ala Lys Arg Ala Arg

35 40 45Gln Ile Asn Ser Phe Tyr His Gln Ala Asp Glu Gly Val Phe Glu Phe

50 55 60Ile Gly Pro Leu Val Thr Pro Gln Pro Gly Glu Lys Pro Leu Ser Ile 65 70 75 80Ala Leu Arg Glu Ile Asn Ala Gly Leu Leu Asp His Glu Glu Gly

859095<210>239<211>1827<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1804)<223>RXC00128<400>239ccattttccg tttggtcttg cctaaagaac cgcatggaaa ttatcgtgaa gcaccgatcc 60cgttgatcgc tccagagaca ccgtgggaag gggagcagca gtg agt aaa att tcg 115

Val Ser Lys Ile Ser

1 5acg aaa ctg aag gcc ctc acc gcg gtg ctg tct gtg acc act ctg gtg 163Thr Lys Leu Lys Ala Leu Thr Ala Val Leu Ser Val Thr Thr Leu Val

10 15 20gct ggg tgt tcc acg ctt ccg cag aac acg gat ccg caa gtg ctg cgc 211Ala Gly Cys Ser Thr Leu Pro Gln Asn Thr Asp Pro Gln Val Leu Arg

25 30 35tca ttt tcc ggg tcc caa agc aca caa gag ata gca ggg ccg acc ccg 259Ser Phe Ser Gly Ser Gln Ser Thr Gln Glu Ile Ala Gly Pro Thr Pro

40 45 50aat caa gat ccg gat ttg ttg atc cgc ggc ttc ttc agc gca ggt gcg 307Asn Gln Asp Pro Asp Leu Leu Ile Arg Gly Phe Phe Ser Ala Gly Ala

55 60 65tat ccg act cag cag tat gaa gcg gcg aag gcg tat ctg acg gaa ggg 355Tyr Pro Thr Gln Gln Tyr Glu Ala Ala Lys Ala Tyr Leu Thr Glu Gly 70 75 80 85acg cgc agc acg tgg aat ccg gct gcg tcg act cgt att ttg gat cgc 403Thr Arg Ser Thr Trp Asn Pro Ala Ala Ser Thr Arg Ile Leu Asp Arg

90 95 100att gat ctg aac act ctg cca ggt tcg acg aat gcg gaa cga acg att 451Ile Asp Leu Asn Thr Leu Pro Gly Ser Thr Asn Ala Glu Arg Thr Ile

105 110 115gcg atc cgt gga acg cag gtc gga acg ttg ctc agc ggt ggc gtg tat 499Ala Ile Arg Gly Thr Gln Val Gly Thr Leu Leu Ser Gly Gly Val Tyr

120 125 130cag ccg gag aat gcg gag ttt gaa gct gag atc acg atg cgt cgg gaa 547Gln Pro Glu Asn Ala Glu Phe Glu Ala Glu Ile Thr Met Arg Arg Glu

135 140 145gat ggg gag tgg cgt atc gat gct ttg ccg gac ggg att tta tta gag 595Asp Gly Glu Trp Arg Ile Asp Ala Leu Pro Asp Gly Ile Leu Leu Glu150 155 160 165aga aac gat ctg cgg aac cat tac act ccg cac gat gtg tat ttc ttt 643Arg Asn Asp Leu Arg Asn His Tyr Thr Pro His Asp Val Tyr Phe Phe

170 175 180gat cct tct ggc cag gtg ttg gtg ggg gat cgg cgt tgg ttg ttc aat 691Asp Pro Ser Gly Gln Val Leu Val Gly Asp Arg Arg Trp Leu Phe Asn

185 190 195gag tcg cag tcg atg tcc acg gtg ctg atg gcc ctt ctg gtt aat ggt 739Glu Ser Gln Ser Met Ser Thr Val Leu Met Ala Leu Leu Val Asn Gly

200 205 210cct tcg ccg gca att tct cct ggt gtg gtc aat cag ctg tcc acg gat 787Pro Ser Pro Ala Ile Ser Pro Gly Val Val Asn Gln Leu Ser Thr Asp

215 220 225gcg tcg ttc gtg ggg ttc aat gat ggg gag tat cag ttc act ggt ttg 835Ala Ser Phe Val Gly Phe Asn Asp Gly Glu Tyr Gln Phe Thr Gly Leu230 235 240 245gga aat ttg gat gat gat gcg cgt ttg cgt ttc gcc gcc cag gcc gtg 883Gly Asn Leu Asp Asp Asp Ala Arg Leu Arg Phe Ala Ala Gln Ala Val

250 255 260tgg acg ttg gcg cat gct gat gtc gca ggc ccc tac act ttg gtc gct 931Trp Thr Leu Ala His Ala Asp Val Ala Gly Pro Tyr Thr Leu Val Ala

265 270 275gac ggc gcg ccg ttg ctg tcg gag ttc cca acg ctc acc acc gat gac 979Asp Gly Ala Pro Leu Leu Ser Glu Phe Pro Thr Leu Thr Thr Asp Asp

280 285 290ctc gcc gaa tac aac cca gag gct tac acc aac acg gtg tcc acg ttg 1027Leu Ala Glu Tyr Asn Pro Glu Ala Tyr Thr Asn Thr Val Ser Thr Leu

295 300 305ttt gcg ttg cag gat gga tcg ttg tcg agg gtc agt tcc ggc aat gtg 1075Phe Ala Leu Gln Asp Gly Ser Leu Ser Arg Val Ser Ser Gly Asn Val310 315 320 325agt cca cta cag ggc att tgg agc ggt gga gat atc gat tct gca gcg 1123Ser Pro Leu Gln Gly Ile Trp Ser Gly Gly Asp Ile Asp Ser Ala Ala

330 335 340att tcc tcc tcc gcc aat gtg gtg gca gcg gta cgc cac gaa aac aac 1171Ile Ser Ser Ser Ala Asn Val Val Ala Ala Val Arg His Glu Asn Asn

345 350 355gag gca gtg ctt act gtt ggc tcc atg gaa ggc gtg act tca gat gcg1219Glu Ala Val Leu Thr Val Gly Ser Met Glu Gly Val Thr Ser Asp Ala

360 365 370ttg agg agt gaa acg atc act cgt ccc acc ttt gaa tac gcg tcg agt 1267Leu Arg Ser Glu Thr Ile Thr Arg Pro Thr Phe Glu Tyr Ala Ser Ser

375 380 385ggg ttg tgg gct gtg gtg gat ggg gag acg cct gtc cga gtc gca cga 1315Gly Leu Trp Ala Val Val Asp Gly Glu Thr Pro Val Arg Val Ala Arg390 395 400 405tcg gca aca acc ggt gag ctc gtc cag acg gag gcg gag att gtg ctg 1363Ser Ala Thr Thr Gly Glu Leu Val Gln Thr Glu Ala Glu Ile Val Leu

410 415 420cca agg gat gtg acg ggt ccg atc tct gaa ttc caa ctg tca cga act 1411Pro Arg Asp Val Thr Gly Pro Ile Ser Glu Phe Gln Leu Ser Arg Thr

425 430 435ggg gtc cgg gcc gcc atg atc att gaa ggc aag gtg tac gtg ggc gtc 1459Gly Val Arg Ala Ala Met Ile Ile Glu Gly Lys Val Tyr Val Gly Val

440 445 450gta acg cgt cct ggt ccg ggc gag cgg cgc gtg aca aat atc acg gag 1507Val Thr Arg Pro Gly Pro Gly Glu Arg Arg Val Thr Asn Ile Thr Glu

455 460 465gtg gcg ccg agc ttg ggc gag gcg gcg ctg tcg atc aac tgg cgc cca 1555Val Ala Pro Ser Leu Gly Glu Ala Ala Leu Ser Ile Asn Trp Arg Pro470 475 480 485gac ggc att ttg ctt gtg ggc acg tca att cca gag acg ccg ctg tgg 1603Asp Gly Ile Leu Leu Val Gly Thr Ser Ile Pro Glu Thr Pro Leu Trp

490 495 500cgc gtc gag cag gac gga tcg gcg att tcg tcg atg ccg agc ggg aat 1651Arg Val Glu Gln Asp Gly Ser Ala Ile Ser Ser Met Pro Ser Gly Asn

505 510 515ctc agc gcg ccg gtg gtg gcg gtg gca agt tcc gcg acg acg gtc tac 1699Leu Ser Ala Pro Val Val Ala Val Ala Ser Ser Ala Thr Thr Val Tyr

520 525 530gtc act gat tcg cat gcg atg ctt cag ctg ccg act gcc gat aat gat 1747Val Thr Asp Ser His Ala Met Leu Gln Leu Pro Thr Ala Asp Asn Asp

535540545 att tgg cgc gag gtg ccc ggt ttg ctg ggc acg cgt gcg gcg ccg gtg 1795Ile Trp Arg Glu Val Pro Gly Leu Leu Gly Thr Arg Ala Ala Pro Val 550555560565 gtt gcg tac tgatggagct gttcttcccg cgc 1827Val Ala Tyr<210>240<211>568<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>240Val Ser Lys Ile Ser Thr Lys Leu Lys Ala Leu Thr Ala Val Leu Ser 151015 Val Thr Thr Leu Val Ala Gly Cys Ser Thr Leu Pro Gln Asn Thr Asp

20 25 30Pro Gln Val Leu Arg Ser Phe Ser Gly Ser Gln Ser Thr Gln Glu Ile

35 40 45Ala Gly Pro Thr Pro Asn Gln Asp Pro Asp Leu Leu Ile Arg Gly Phe

50 55 60Phe Ser Ala Gly Ala Tyr Pro Thr Gln Gln Tyr Glu Ala Ala Lys Ala 65 70 75 80Tyr Leu Thr Glu Gly Thr Arg Ser Thr Trp Asn Pro Ala Ala Ser Thr

85 90 95Arg Ile Leu Asp Arg Ile Asp Leu Asn Thr Leu Pro Gly Ser Thr Asn

100 105 110Ala Glu Arg Thr Ile Ala Ile Arg Gly Thr Gln Val Gly Thr Leu Leu

115 120 125Ser Gly Gly Val Tyr Gln Pro Glu Asn Ala Glu Phe Glu Ala Glu Ile

130 135 140Thr Met Arg Arg Glu Asp Gly Glu Trp Arg Ile Asp Ala Leu Pro Asp145 150 155 160Gly Ile Leu Leu Glu Arg Asn Asp Leu Arg Asn His Tyr Thr Pro His

165 170 175Asp Val Tyr Phe Phe Asp Pro Ser Gly Gln Val Leu Val Gly Asp Arg

180 185 190Arg Trp Leu Phe Asn Glu Ser Gln Ser Met Ser Thr Val Leu Met Ala

195 200 205Leu Leu Val Asn Gly Pro Ser Pro Ala Ile Ser Pro Gly Val Val Asn

210 215 220Gln Leu Ser Thr Asp Ala Ser Phe Val Gly Phe Asn Asp Gly Glu Tyr225 230 235 240Gln Phe Thr Gly Leu Gly Asn Leu Asp Asp Asp Ala Arg Leu Arg Phe

245 250 255Ala Ala Gln Ala Val Trp Thr Leu Ala His Ala Asp Val Ala Gly Pro

260 265 270Tyr Thr Leu Val Ala Asp Gly Ala Pro Leu Leu Ser Glu Phe Pro Thr

275 280 285Leu Thr Thr Asp Asp Leu Ala Glu Tyr Asn Pro Glu Ala Tyr Thr Asn

290 295 300Thr Val Ser Thr Leu Phe Ala Leu Gln Asp Gly Ser Leu Ser Arg Val305 310 315 320Ser Ser Gly Asn Val Ser Pro Leu Gln Gly Ile Trp Ser Gly Gly Asp

325 330 335Ile Asp Ser Ala Ala Ile Ser Ser Ser Ala Asn Val Val Ala Ala Val

340 345 350Arg His Glu Asn Asn Glu Ala Val Leu Thr Val Gly Ser Met Glu Gly

355 360 365Val Thr Ser Asp Ala Leu Arg Ser GluThr Ile Thr Arg Pro Thr Phe

370 375 380Glu Tyr Ala Ser Ser Gly Leu Trp Ala Val Val Asp Gly Glu Thr Pro385 390 395 400Val Arg Val Ala Arg Ser Ala Thr Thr Gly Glu Leu Val Gln Thr Glu

405 410 415Ala Glu Ile Val Leu Pro Arg Asp Val Thr Gly Pro Ile Ser Glu Phe

420 425 430Gln Leu Ser Arg Thr Gly Val Arg Ala Ala Met Ile Ile Glu Gly Lys

435 440 445Val Tyr Val Gly Val Val Thr Arg Pro Gly Pro Gly Glu Arg Arg Val

450 455 460Thr Asn Ile Thr Glu Val Ala Pro Ser Leu Gly Glu Ala Ala Leu Ser465 470 475 480Ile Asn Trp Arg Pro Asp Gly Ile Leu Leu Val Gly Thr Ser Ile Pro

485 490 495Glu Thr Pro Leu Trp Arg Val Glu Gln Asp Gly Ser Ala Ile Ser Ser

500 505 510Met Pro Ser Gly Asn Leu Ser Ala Pro Val Val Ala Val Ala Ser Ser

515 520 525Ala Thr Thr Val Tyr Val Thr Asp Ser His Ala Met Leu Gln Leu Pro

530 535 540Thr Ala Asp Asn Asp Ile Trp Arg Glu Val Pro Gly Leu Leu Gly Thr545 550 555 560Arg Ala Ala Pro Val Val Ala Tyr

565<210>241<211>1344<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1321)<223>RXA02240<400>241cagctagacc actgacattg cagttttaga cagcttggtc tatattggtt ttttgtattt 60aagactattt attctcaact tcttcgaaag aagggtattt gtg gct cag cca acc 115

Val Ala Gln Pro Thr

1 5gcc gtc cgt ttg ttc acc agt gaa tct gta act gag gga cat cca gac 163Ala Val Arg Leu Phe Thr Ser Glu Ser Val Thr Glu Gly His Pro Asp

10 15 20aaa ata tgt gat gct att tcc gat acc att ttg gac gcg ctg ctc gaa 211Lys Ile Cys Asp Ala Ile Ser Asp Thr Ile Leu Asp Ala Leu Leu Glu

25 30 35aaa gat ccg cag tcg cgc gtc gca gtg gaa act gtg gtc acc acc gga 259Lys Asp Pro Gln Ser Arg Val Ala Val Glu Thr Val Val Thr Thr Gly

40 45 50atc gtc cat gtt gtt ggc gag gtc cgt acc agc gct tac gta gag atc 307Ile Val His Val Val Gly Glu Val Arg Thr Ser Ala Tyr Val Glu Ile

55 60 65cct caa tta gtc cgc aac aag ctc atc gaa atc gga ttc aac tcc tct 355Pro Gln Leu Val Arg Asn Lys Leu Ile Glu Ile Gly Phe Asn Ser Ser 70 75 80 85gag gtt gga ttc gac gga cgc acc tgt ggc gtc tca gta tcc atc ggt 403Glu Val Gly Phe Asp Gly Arg Thr Cys Gly Val Ser Val Ser Ile Gly

90 95 100gag cag tcc cag gaa atc gct gac ggc gtg gat aac tcc gac gaa gcc 451Glu Gln Ser Gln Glu Ile Ala Asp Gly Val Asp Asn Ser Asp Glu Ala

105 110 115cgc acc aac ggc gac gtt gaa gaa gac gac cgc gca ggt gct ggc gac 499Arg Thr Asn Gly Asp Val Glu Glu Asp Asp Arg Ala Gly Ala Gly Asp

120 125 130cag ggc ctg atg ttc ggc tac gcc acc aac gaa acc gaa gag tac atg 547Gln Gly Leu Met Phe Gly Tyr Ala Thr Asn Glu Thr Glu Glu Tyr Met

135 140 145cct ctt cct atc gcg ttg gcg cac cga ctg tca cgt cgt ctg acc cag 595Pro Leu Pro Ile Ala Leu Ala His Arg Leu Ser Arg Arg Leu Thr Gln150 155 160 165gtt cgt aaa gag ggc atc gtt cct cac ctg cgt cca gac gga aaa acc 643Val Arg Lys Glu Gly Ile Val Pro His Leu Arg Pro Asp Gly Lys Thr

170 175 180cag gtc acc ttc gca tac gat gcg caa gac cgc cct agc cac ctg gat 691Gln Val Thr Phe Ala Tyr Asp Ala Gln Asp Arg Pro Ser His Leu Asp

185 190 195acc gtt gtc atc tcc acc cag cac gac cca gaa gtt gac cgt gca tgg 739Thr Val Val Ile Ser Thr Gln His Asp Pro Glu Val Asp Arg Ala Trp

200 205 210ttg gaa acc caa ctg cgc gaa cac gtc att gat tgg gta atc aaa gac 787Leu Glu Thr Gln Leu Arg Glu His Val Ile Asp Trp Val Ile Lys Asp

215 220 225gca ggc att gag gat ctg gca acc ggt gag atc acc gtg ttg atc aac 835Ala Gly Ile Glu Asp Leu Ala Thr Gly Glu Ile Thr Val Leu Ile Asn230 235 240 245cct tca ggt tcc ttc att ctg ggt ggc ccc atg ggt gat gcg ggt ctg 883Pro Ser Gly Ser Phe Ile Leu Gly Gly Pro Met Gly Asp Ala Gly Leu

250 255 260acc ggc cgc aag atc atc gtg gat acc tac ggt ggc atg gct cgc cat 931Thr Gly Arg Lys Ile Ile Val Asp Thr Tyr Gly Gly Met Ala Arg His

265 270 275ggt ggt gga gca ttc tcc ggt aag gat cca agc aag gtg gac cgc tct 979Gly Gly Gly Ala Phe Ser Gly Lys Asp Pro Ser Lys Val Asp Arg Ser

280 285 290gct gca tac gcc atg cgt tgg gta gca aag aac atc gtg gca gca ggc 1027Ala Ala Tyr Ala Met Arg Trp Val Ala Lys Asn Ile Val Ala Ala Gly

295 300 305ctt gct gat cgc gct gaa gtt cag gtt gca tac gcc att gga cgc gca 1075Leu Ala Asp Arg Ala Glu Val Gln Val Ala Tyr Ala Ile Gly Arg Ala310 315 320 325aag cca gtc gga ctt tac gtt gaa acc ttt gac acc aac aag gaa ggc 1123Lys Pro Val Gly Leu Tyr Val Glu Thr Phe Asp Thr Asn Lys Glu Gly

330 335 340ctg agc gac gag cag att cag gct gcc gtg ttg gag gtc ttt gac ctg 1171Leu Ser Asp Glu Gln Ile Gln Ala Ala Val Leu Glu Val Phe Asp Leu

345 350 355cgt cca gca gca att atc cgt gag ctt gat ctg ctt cgt ccg atc tac 1219Arg Pro Ala Ala Ile Ile Arg Glu Leu Asp Leu Leu Arg Pro Ile Tyr

360 365 370gct gac act gct gcc tac ggc cac ttt ggt cgc act gat ttg gac ctt 1267Ala Asp Thr Ala Ala Tyr Gly His Phe Gly Arg Thr Asp Leu Asp Leu

375380385 cct tgg gag gct atc gac cgc gtt gat gaa ctt cgc gca gcc ctc aag 1315Pro Trp Glu Ala Ile Asp Arg Val Asp Glu Leu Arg Ala Ala Leu Lys 390395400405 ttg gcc taaaaatctg atgtagtatc ttc 1344Leu Ala<210>242<211>407<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>242Val Ala Gln Pro Thr Ala Val Arg Leu Phe Thr Ser Glu Ser Val Thr 151015 Glu Gly His Pro Asp Lys Ile Cys Asp Ala Ile Ser Asp Thr Ile Leu

20 25 30Asp Ala Leu Leu Glu Lys Asp Pro Gln Ser Arg Val Ala Val Glu Thr

35 40 45Val Val Thr Thr Gly Ile Val His Val Val Gly Glu Val Arg Thr Ser

50 55 60Ala Tyr Val Glu Ile Pro Gln Leu Val Arg Asn Lys Leu Ile Glu Ile 65 70 75 80Gly Phe Asn Ser Ser Glu Val Gly Phe Asp Gly Arg Thr Cys Gly Val

85 90 95Ser Val Ser Ile Gly Glu Gln Ser Gln Glu Ile Ala Asp Gly Val Asp

100 105 110Asn Ser Asp Glu Ala Arg Thr Asn Gly Asp Val Glu Glu Asp Asp Arg

115 120 125Ala Gly Ala Gly Asp Gln Gly Leu Met Phe Gly Tyr Ala Thr Asn Glu

130 135 140Thr Glu Glu Tyr Met Pro Leu Pro Ile Ala Leu Ala His Arg Leu Ser145 150 155 160Arg Arg Leu Thr Gln Val Arg Lys Glu Gly Ile Val Pro His Leu Arg

165 170 175Pro Asp Gly Lys Thr Gln Val Thr Phe Ala Tyr Asp Ala Gln Asp Arg

180 185 190Pro Ser His Leu Asp Thr Val Val Ile Ser Thr Gln His Asp Pro Glu

195 200 205Val Asp Arg Ala Trp Leu Glu Thr Gln Leu Arg Glu His Val Ile Asp

210 215 220Trp Val Ile Lys Asp Ala Gly Ile Glu Asp Leu Ala Thr Gly Glu Ile225 230 235 240Thr Val Leu Ile Asn Pro Ser Gly Ser Phe Ile Leu Gly Gly Pro Met

245 250 255Gly Asp Ala Gly Leu Thr Gly Arg Lys Ile Ile Val Asp Thr Tyr Gly

260 265 270Gly Met Ala Arg His Gly Gly Gly Ala Phe Ser Gly Lys Asp ProSer

275 280 285Lys Val Asp Arg Ser Ala Ala Tyr Ala Met Arg Trp Val Ala Lys Asn

290 295 300Ile Val Ala Ala Gly Leu Ala Asp Arg Ala Glu Val Gln Val Ala Tyr305 310 315 320Ala Ile Gly Arg Ala Lys Pro Val Gly Leu Tyr Val Glu Thr Phe Asp

325 330 335Thr Asn Lys Glu Gly Leu Ser Asp Glu Gln Ile Gln Ala Ala Val Leu

340 345 350Glu Val Phe Asp Leu Arg Pro Ala Ala Ile Ile Arg Glu Leu Asp Leu

355 360 365Leu Arg Pro Ile Tyr Ala Asp Thr Ala Ala Tyr Gly His Phe Gly Arg

370 375 380Thr Asp Leu Asp Leu Pro Trp Glu Ala Ile Asp Arg Val Asp Glu Leu385 390 395 400Arg Ala Ala Leu Lys Leu Ala

405<210>243<211>669<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (646)<223>RXA00780<400>243ccttttaagt ccttctttgc ccgtgaataa ttctctggat agtttccacg tgcagttaag 60tcacgctgtt agacttgcct gcatgctctc gacaataaaa atg atc cgt gaa gat 115

Met Ile Arg Glu Asp

1 5ctc gca aac gct cgt gaa cac gat cca gca gcc cga ggc gat tta gaa 163Leu Ala Asn Ala Arg Glu His Asp Pro Ala Ala Arg Gly Asp Leu Glu

10 15 20aac gca gtg gtt tac tcc gga ctc cac gcc atc tgg gca cat cga gtt 211Asn Ala Val Val Tyr Ser Gly Leu His Ala Ile Trp Ala His Arg Val

25 30 35gcc aac agc tgg tgg aaa tcc ggt ttc cgc ggc ccc gcc cgc gta tta 259Ala Asn Ser Trp Trp Lys Ser Gly Phe Arg Gly Pro Ala Arg Val Leu

40 45 50gcc caa ttc acc cga ttc ctc acc ggc att gaa att cac ccc ggt gcc 307Ala Gln Phe Thr Arg Phe Leu Thr Gly Ile Glu Ile His Pro Gly Ala

55 60 65acc att ggt cgt cgc ttt ttt att gac cac gga atg gga atc gtc atc 355Thr Ile Gly Arg Arg Phe Phe Ile Asp His Gly Met Gly Ile Val Ile 70 75 80 85ggc gaa acc gct gaa atc ggc gaa ggc gtc atg ctc tac cac ggc gtc 403Gly Glu Thr Ala Glu Ile Gly Glu Gly Val Met Leu Tyr His Gly Val

90 95 100acc ctc ggc gga cag gtt ctc acc caa acc aag cgc cac ccc acg ctc 451Thr Leu Gly Gly Gln Val Leu Thr Gln Thr Lys Arg His Pro Thr Leu

105 110 115tgc gac aac gtg aca gtc ggc gcg ggc gca aaa atc tta ggt ccc atc 499Cys Asp Asn Val Thr Val Gly Ala Gly Ala Lys Ile Leu Gly Pro Ile

120 125 130acc atc ggc gaa ggc tcc gca att ggc gcc aat gca gtt gtc acc aaa 547Thr Ile Gly Glu Gly Ser Ala Ile Gly Ala Asn Ala Val Val Thr Lys

135 140 145gac gtg ccg gca gaa cac atc gca gtc gga att cct gcg gta gca cgc 595Asp Val Pro Ala Glu His Ile Ala Val Gly Ile Pro Ala Val Ala Arg150 155 160 165cca cgt ggc aag aca gag aag atc aag ctc gtc gat ccg gac tat tac 643Pro Arg Gly Lys Thr Glu Lys Ile Lys Leu Val Asp Pro Asp Tyr Tyr

170175180 att taagaacagt tagcgcccta cct 669Ile<210>244<211>182<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>244Met Ile Arg Glu Asp Leu Ala Asn Ala Arg Glu His Asp Pro Ala Ala 151015 Arg Gly Asp Leu Glu Asn Ala Val Val Tyr Ser Gly Leu His Ala Ile

20 25 30Trp Ala His Arg Val Ala Asn Ser Trp Trp Lys Ser Gly Phe Arg Gly

35 40 45Pro Ala Arg Val Leu Ala Gln Phe Thr Arg Phe Leu Thr Gly Ile Glu

50 55 60Ile His Pro Gly Ala Thr Ile Gly Arg Arg Phe Phe Ile Asp His Gly 65 70 75 80Met Gly Ile Val Ile Gly Glu Thr Ala Glu Ile Gly Glu Gly Val Met

85 90 95Leu Tyr His Gly Val Thr Leu Gly Gly Gln Val Leu Thr Gln Thr Lys

100 105 110Arg His Pro Thr Leu Cys Asp Asn Val Thr Val Gly Ala Gly Ala Lys

115 120 125Ile Leu Gly Pro Ile Thr Ile Gly Glu Gly Ser Ala Ile Gly Ala Asn

130 135 140Ala Val Val Thr Lys Asp Val Pro Ala Glu His Ile Ala Val Gly Ile145 150 155 160Pro Ala Val Ala Arg Pro Arg Gly Lys Thr Glu Lys Ile Lys Leu Val

165 170 175Asp Pro Asp Tyr Tyr Ile

180<210>245<211>1056<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1033)<223>RXA00779<400>245cagaggccac ttcaagtaga tgtttcgtaa ttgtttacag cgtttacgca agcggtcgac 60caacaaaaac agcacttcaa tgattggagc accacccgac atg ggc aat gtg tac 115

Met Gly Asn Val Tyr

1 5aac aac atc acc gaa acc atc ggc cac acc cca ctg gta aag ctg aac 163Asn Asn Ile Thr Glu Thr Ile Gly His Thr Pro Leu Val Lys Leu Asn

10 15 20aag ctc acc gaa ggc ctc gac gca act gtc ctg gtc aag ctt gag tca 211Lys Leu Thr Glu Gly Leu Asp Ala Thr Val Leu Val Lys Leu Glu Ser

25 30 35ttc aac cca gca aac tcc gtc aag gac cgt atc ggt ctg gcc atc gtt 259Phe Asn Pro Ala Asn Ser Val Lys Asp Arg Ile Gly Leu Ala Ile Val

40 45 50gaa gat gca gag aag tcc ggt gca ctg aag cca ggc ggc acc atc gtt 307Glu Asp Ala Glu Lys Ser Gly Ala Leu Lys Pro Gly Gly Thr Ile Val

55 60 65gaa gca acc tcc ggc aac acc ggt atc gca ctg gca atg gtc ggc gct 355Glu Ala Thr Ser Gly Asn Thr Gly Ile Ala Leu Ala Met Val Gly Ala 70 75 80 85gca cgc gga tac aac gtt gtt ctc acc atg ccg gag acc atg tcc aac 403Ala Arg Gly Tyr Asn Val Val Leu Thr Met Pro Glu Thr Met Ser Asn

90 95 100gag cgt cgc gtt ctc ctc cgc gct tac ggt gca gag atc gtt ctt acc 451Glu Arg Arg Val Leu Leu Arg Ala Tyr Gly Ala Glu Ile Val Leu Thr

105 110 115cca ggt gca gca ggc atg cag ggt gca aag gac aag gca gac gaa atc 499Pro Gly Ala Ala Gly Met Gln Gly Ala Lys Asp Lys Ala Asp Glu Ile

120 125 130gtc gct gaa cgc gaa aac gca gtc ctt gct cgc cag ttc gag aac gag 547Val Ala Glu Arg Glu Asn Ala Val Leu Ala Arg Gln PheGlu Asn Glu

135 140 145gca aac cca cgc gtc aac cgc gac acc acc gcg aag gaa atc ctc gaa 595Ala Asn Pro Arg Val Asn Arg Asp Thr Thr Ala Lys Glu Ile Leu Glu150 155 160 165gac acc gac ggc acc gtt gat atc ttc gtt gca agc ttc ggc acc ggc 643Asp Thr Asp Gly Thr Val Asp Ile Phe Val Ala Ser Phe Gly Thr Gly

170 175 180gga acc gtc acc ggc gtt ggc cag gtc ctg aag gaa aac aac gca gac 691Gly Thr Val Thr Gly Val Gly Gln Val Leu Lys Glu Asn Asn Ala Asp

185 190 195gta cag gtc tac acc gtc gag cca gaa gcg tcc cca ctt ctg acc gct 739Val Gln Val Tyr Thr Val Glu Pro Glu Ala Ser Pro Leu Leu Thr Ala

200 205 210ggc aag gct ggt cca cac aag atc cag ggc atc ggc gca aac ttc atc 787Gly Lys Ala Gly Pro His Lys Ile Gln Gly Ile Gly Ala Asn Phe Ile

215 220 225ccc gag gtc ctg gac cgc aag gtt ctc gac gac gtg ctg acc gtc tcc 835Pro Glu Val Leu Asp Arg Lys Val Leu Asp Asp Val Leu Thr Val Ser230 235 240 245aac gaa gac gca atc gca ttc tcc cgc aag ctc gct acc gaa gag ggc 883Asn Glu Asp Ala Ile Ala Phe Ser Arg Lys Leu Ala Thr Glu Glu Gly

250 255 260atc ctc ggc ggt atc tcc acc ggc gca aac atc aag gca gct ctt gac 931Ile Leu Gly Gly Ile Ser Thr Gly Ala Asn Ile Lys Ala Ala Leu Asp

265 270 275ctt gca gca aag cca gag aac gct ggc aaa acc atc gtc acc gtt gtc 979Leu Ala Ala Lys Pro Glu Asn Ala Gly Lys Thr Ile Val Thr Val Val

280 285 290acc gac ttc ggc gag cgc tac gtc tcc acc gtt ctt tac gaa gac atc 1027Thr Asp Phe Gly Glu Arg Tyr Val Ser Thr Val Leu Tyr Glu Asp Ile

295300305 cgc gac taattcttag cgactgttaa cca 1056Arg Asp310<210>246<211>311<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>246Met Gly Asn Val Tyr Asn Asn Ile Thr Glu Thr Ile Gly His Thr Pro 151015 Leu Val Lys Leu Asn Lys Leu Thr Glu Gly Leu Asp Ala Thr Val Leu

20 25 30Val Lys Leu Glu Ser Phe Asn Pro Ala Asn Ser Val Lys Asp Arg Ile

35 40 45Gly Leu Ala Ile Val Glu Asp Ala Glu Lys Ser Gly Ala Leu Lys Pro

50 55 60Gly Gly Thr Ile Val Glu Ala Thr Ser Gly Asn Thr Gly Ile Ala Leu 65 70 75 80Ala Met Val Gly Ala Ala Arg Gly Tyr Asn Val Val Leu Thr Met Pro

85 90 95Glu Thr Met Ser Asn Glu Arg Arg Val Leu Leu Arg Ala Tyr Gly Ala

100 105 110Glu Ile Val Leu Thr Pro Gly Ala Ala Gly Met Gln Gly Ala Lys Asp

115 120 125Lys Ala Asp Glu Ile Val Ala Glu Arg Glu Asn Ala Val Leu Ala Arg

130 135 140Gln Phe Glu Asn Glu Ala Asn Pro Arg Val Asn Arg Asp Thr Thr Ala145 150 155 160Lys Glu Ile Leu Glu Asp Thr Asp Gly Thr Val Asp Ile Phe Val Ala

165 170 175Ser Phe Gly Thr Gly Gly Thr Val Thr Gly Val Gly Gln Val Leu Lys

180 185 190Glu Asn Asn Ala Asp Val Gln Val Tyr Thr Val Glu Pro Glu Ala Ser

195 200 205Pro Leu Leu Thr Ala Gly Lys Ala Gly Pro His Lys Ile Gln Gly Ile

210 215 220Gly Ala Asn Phe Ile Pro Glu Val Leu Asp Arg Lys Val Leu Asp Asp225 230 235 240Val Leu Thr Val Ser Asn Glu Asp Ala Ile Ala Phe Ser Arg Lys Leu

245 250 255Ala Thr Glu Glu Gly Ile Leu Gly Gly Ile Ser Thr Gly Ala Asn Ile

260 265 270Lys Ala Ala Leu Asp Leu Ala Ala Lys Pro Glu Asn Ala Gly Lys Thr

275 280 285Ile Val Thr Val Val Thr Asp Phe Gly Glu Arg Tyr Val Ser Thr Val

290295300 Leu Tyr Glu Asp Ile Arg Asp 305310<210>247<211>623<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1).<600)<223>RXN00402<400>247act gac gaa aag gat gga aag cca gta ttg ccc tac ttc gtc act cca 48Thr Asp Glu Lys Asp Gly Lys Pro Val Leu Pro Tyr Phe Val Thr Pro 151015 gat gct gct tac cac gga ttg aag tac gca gac ctt ggt gca cca gcc 96Asp Ala Ala Tyr His Gly Leu Lys Tyr Ala Asp Leu Gly Ala Pro Ala>247,52,213

20 25 30ttc ggc ctc aag gtt cgc gtt ggc ctt cta cgc gac acc ggc tcc acc 144Phe Gly Leu Lys Val Arg Val Gly Leu Leu Arg Asp Thr Gly Ser Thr

35 40 45ctc tcc gca ttc aac gca tgg gct gca gtc cag ggc atc gac acc ctt 192Leu Ser Ala Phe Asn Ala Trp Ala Ala Val Gln Gly Ile Asp Thr Leu

50 55 60tcc ctg cgc ctg gag cgc cac aac gaa aac gcc atc aag gtt gca gaa 240Ser Leu Arg Leu Glu Arg His Asn Glu Asn Ala Ile Lys Val Ala Glu 65 70 75 80ttc ctc aac aac cac gag aag gtg gaa aag gtt aac ttc gca ggc ctg 288Phe Leu Asn Asn His Glu Lys Val Glu Lys Val Asn Phe Ala Gly Leu

85 90 95aag gat tcc cct tgg tac gca acc aag gaa aag ctt ggc ctg aag tac 336Lys Asp Ser Pro Trp Tyr Ala Thr Lys Glu Lys Leu Gly Leu Lys Tyr

100 105 110acc ggc tcc gtt ctc acc ttc gag atc aag ggc ggc aag gat gag gct 384Thr Gly Ser Val Leu Thr Phe Glu Ile Lys Gly Gly Lys Asp Glu Ala

115 120 125tgg gca ttt atc gac gcc ctg aag cta cac tcc aac ctt gca aac atc 432Trp Ala Phe Ile Asp Ala Leu Lys Leu His Ser Asn Leu Ala Asn Ile

130 135 140ggc gat gtt cgc tcc ctc gtt gtt cac cca gca acc acc acc cat tca 480Gly Asp Val Arg Ser Leu Val Val His Pro Ala Thr Thr Thr His Ser145 150 155 160cag tcc gac gaa gct ggc ctg gca cgc gcg ggc gtt acc cag tcc acc 528Gln Ser Asp Glu Ala Gly Leu Ala Arg Ala Gly Val Thr Gln Ser Thr

165 170 175gtc cgc ctg tcc gtt ggc atc gag acc att gat gat atc atc gct gac 576Val Arg Leu Ser Val Gly Ile Glu Thr Ile Asp Asp Ile Ile Ala Asp

180 185 190ctc gaa ggc ggc ttt gct gca atc tagctttaaa tagactcacc cca 623Leu Glu Gly Gly Phe Ala Ala Ile

195200<210>248<211>200<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>248Thr Asp Glu Lys Asp Gly Lys Pro Val Leu Pro Tyr Phe Val Thr Pro 151015 Asp Ala Ala Tyr His Gly Leu Lys TyrAla Asp Leu Gly Ala Pro Ala

20 25 30Phe Gly Leu Lys Val Arg Val Gly Leu Leu Arg Asp Thr Gly Ser Thr

35 40 45Leu Ser Ala Phe Asn Ala Trp Ala Ala Val Gln Gly Ile Asp Thr Leu

50 55 60Ser Leu Arg Leu Glu Arg His Asn Glu Asn Ala Ile Lys Val Ala Glu 65 70 75 80Phe Leu Asn Asn His Glu Lys Val Glu Lys Val Asn Phe Ala Gly Leu

85 90 95Lys Asp Ser Pro Trp Tyr Ala Thr Lys Glu Lys Leu Gly Leu Lys Tyr

100 105 110Thr Gly Ser Val Leu Thr Phe Glu Ile Lys Gly Gly Lys Asp Glu Ala

115 120 125Trp Ala Phe Ile Asp Ala Leu Lys Leu His Ser Asn Leu Ala Asn Ile

130 135 140Gly Asp Val Arg Ser Leu Val Val His Pro Ala Thr Thr Thr His Ser145 150 155 160Gln Ser Asp Glu Ala Gly Leu Ala Arg Ala Gly Val Thr Gln Ser Thr

165 170 175Val Arg Leu Ser Val Gly Ile Glu Thr Ile Asp Asp Ile Ile Ala Asp

180 185 190Leu Glu Gly Gly Phe Ala Ala Ile

195200<210>249<211>599<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) } (576)<223>FRXA00402<400>249gta ttg ccc tac ttc gtc act cca gat gct gct tac cac gga ttg aag 48Val Leu Pro Tyr Phe Val Thr Pro Asp Ala Ala Tyr His Gly Leu Lys 151015 tac gca gac ctt ggt gca cca gcc ttc ggc ctc aag gtt cgc gtt ggc 96Tyr Ala Asp Leu Gly Ala Pro Ala Phe Gly Leu Lys Val Arg Val Gly

20 25 30ctt cta cgc gac acc ggc tcc acc ctc tcc gca ttc aac gca tgg gct 144Leu Leu Arg Asp Thr Gly Ser Thr Leu Ser Ala Phe Asn Ala Trp Ala

35 40 45gca gtc cag ggc atc gac acc ctt tcc ctg cgc ctg gag cgc cac aac 192Ala Val Gln Gly Ile Asp Thr Leu Ser Leu Arg Leu Glu Arg His Asn

50 55 60gaa aac gcc atc aag gtt gca gaa ttc ctc aac aac cac gag aag gtg 240Glu Asn Ala Ile Lys Val Ala Glu Phe Leu Asn Asn His Glu Lys Val 65 70 75 80gaa aag gtt aac ttc gca ggc ctg aag gat tcc cct tgg tac gca acc 288Glu Lys Val Asn Phe Ala Gly Leu Lys Asp Ser Pro Trp Tyr Ala Thr

85 90 95aag gaa aag ctt ggc ctg aag tac acc ggc tcc gtt ctc acc ttc gag 336Lys Glu Lys Leu Gly Leu Lys Tyr Thr Gly Ser Val Leu Thr Phe Glu

100 105 110atc aag ggc ggc aag gat gag gct tgg gca ttt atc gac gcc ctg aag 384Ile Lys Gly Gly Lys Asp Glu Ala Trp Ala Phe Ile Asp Ala Leu Lys

115 120 125cta cac tcc aac ctt gca aac atc ggc gat gtt cgc tcc ctc gtt gtt 432Leu His Ser Asn Leu Ala Asn Ile Gly Asp Val Arg Ser Leu Val Val

130 135 140cac cca gca acc acc acc cat tca cag tcc gac gaa gct ggc ctg gca 480His Pro Ala Thr Thr Thr His Ser Gln Ser Asp Glu Ala Gly Leu Ala145 150 155 160cgc gcg ggc gtt acc cag tcc acc gtc cgc ctg tcc gtt ggc atc gag 528Arg Ala Gly Val Thr Gln Ser Thr Val Arg Leu Ser Val Gly Ile Glu

165 170 175acc att gat gat atc atc gct gac ctc gaa ggc ggc ttt gct gca atc 576Thr Ile Asp Asp Ile Ile Ala Asp Leu Glu Gly Gly Phe Ala Ala Ile

180185190 tagctttaaa tagactcacc cca 599<210>250<211>192<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>250Val Leu Pro Tyr Phe Val Thr Pro Asp Ala Ala Tyr His Gly Leu Lys 151015 Tyr Ala Asp Leu Gly Ala Pro Ala Phe Gly Leu Lys Val Arg Val Gly

20 25 30Leu Leu Arg Asp Thr Gly Ser Thr Leu Ser Ala Phe Asn Ala Trp Ala

35 40 45Ala Val Gln Gly Ile Asp Thr Leu Ser Leu Arg Leu Glu Arg His Asn

50 55 60Glu Asn Ala Ile Lys Val Ala Glu Phe Leu Asn Asn His Glu Lys Val65 70 75 80Glu Lys Val Asn Phe Ala Gly Leu Lys Asp Ser Pro Trp Tyr Ala Thr

85 90 95Lys Glu Lys Leu Gly Leu Lys Tyr Thr Gly Ser Val Leu Thr Phe Glu

100 105 110Ile Lys Gly Gly Lys Asp Glu Ala Trp Ala Phe Ile Asp Ala Leu Lys

115 120 125Leu His Ser Asn Leu Ala Asn Ile Gly Asp Val Arg Ser Leu Val Val

130 135 140His Pro Ala Thr Thr Thr His Ser Gln Ser Asp Glu Ala Gly Leu Ala145 150 155 160Arg Ala Gly Val Thr Gln Ser Thr Val Arg Leu Ser Val Gly Ile Glu

165 170 175Thr Ile Asp Asp Ile Ile Ala Asp Leu Glu Gly Gly Phe Ala Ala Ile

180185190<210>251<211>613<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (613)<223>RXS00405<400>251agaataaatt tataccacac agtctattgc aatagaccaa gctgttcagt agggtgcatg 60ggagaagaat ttcctaataa aaactcttaa ggacctccaa atg cca aag tac gac 115

Met Pro Lys Tyr Asp

1 5aat tcc aat gct gac cag tgg ggc ttt gaa acc cgc tcc att cac gca 163Asn Ser Asn Ala Asp Gln Trp Gly Phe Glu Thr Arg Ser Ile His Ala

10 15 20ggc cag tca gta gac gca cag acc agc gca cga aac ctt ccg atc tac 211Gly Gln Ser Val Asp Ala Gln Thr Ser Ala Arg Asn Leu Pro Ile Tyr

25 30 35caa tcc acc gct ttc gtg ttc gac tcc gct gag cac gcc aag cag cgt 259Gln Ser Thr Ala Phe Val Phe Asp Ser Ala Glu His Ala Lys Gln Arg

40 45 50ttc gca ctt gag gat cta ggc cct gtt tac tcc cgc ctc acc aac cca 307Phe Ala Leu Glu Asp Leu Gly Pro Val Tyr Ser Arg Leu Thr Asn Pro

55 60 65acc gtt gag gct ttg gaa aac cgc atc gct tcc ctc gaa ggt ggc gtc 355Thr Val Glu Ala Leu Glu Asn Arg Ile Ala Ser Leu Glu Gly Gly Val 70 75 80 85cac gct gta gcg ttc tcc tcc gga cag gcc gca acc acc aac gcc att 403His Ala Val Ala Phe Ser Ser Gly Gln Ala Ala Thr Thr Asn Ala Ile

90 95 100ttg aac ctg gca gga gcg ggc gac cac atc gtc acc tcc cca cgc ctc 451Leu Asn Leu Ala Gly Ala Gly Asp His Ile Val Thr Ser Pro Arg Leu

105 110 115tac ggt ggc acc gag act cta ttc ctt atc act ctt aac cgc ctg ggt 499Tyr Gly Gly Thr Glu Thr Leu Phe Leu Ile Thr Leu Asn Arg Leu Gly

120 125 130atc gat gtt tcc ttc gtg gaa aac ccc gac gac cct gag tcc tgg cag 547Ile Asp Val Ser Phe Val Glu Asn Pro Asp Asp Pro Glu Ser Trp Gln

135 140 145gca gcc gtt cag cca aac acc aaa gca ttc ttc ggc gag act ttc gcc 595Ala Ala Val Gln Pro Asn Thr Lys Ala Phe Phe Gly Glu Thr Phe Ala150 155 160 165aac cca cag gca gac gtc 613Asn Pro Gln Ala Asp Val

170<210>252<211>171<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>252Met Pro Lys Tyr Asp Asn Ser Asn Ala Asp Gln Trp Gly Phe Glu Thr 151015 Arg Ser Ile His Ala Gly Gln Ser Val Asp Ala Gln Thr Ser Ala Arg

20 25 30Asn Leu Pro Ile Tyr Gln Ser Thr Ala Phe Val Phe Asp Ser Ala Glu

35 40 45His Ala Lys Gln Arg Phe Ala Leu Glu Asp Leu Gly Pro Val Tyr Ser

50 55 60Arg Leu Thr Asn Pro Thr Val Glu Ala Leu Glu Asn Arg Ile Ala Ser 65 70 75 80Leu Glu Gly Gly Val His Ala Val Ala Phe Ser Ser Gly Gln Ala Ala

85 90 95Thr Thr Asn Ala Ile Leu Asn Leu Ala Gly Ala Gly Asp His Ile Val

100 105 110Thr Ser Pro Arg Leu Tyr Gly Gly Thr Glu Thr Leu Phe Leu Ile Thr

115 120 125Leu Asn Arg Leu Gly Ile Asp Val Ser Phe Val Glu Asn Pro Asp Asp

130 135 140Pro Glu Ser Trp Gln Ala Ala Val Gln Pro Asn Thr Lys Ala Phe Phe145 150 155 160Gly Glu Thr Phe Ala Asn Pro Gln Ala Asp Val

165170<210>253<211>1812<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1789)<223>RXC00164<400>253ctgctttgcg ggaggttatg aaatgagtgg ggagacgtcg aaaagcatgc gctttccgtt 60ggccagcctg ccgcaagtgc ggcgcgaggt ggcccggcag gtg ggt cgt att ccg 115

Val Gly Arg Ile Pro

1 5cgg gcg aag tgg tgg ttt tta ggc gcg ctg gtg ttg ctg agt gcg ggc 163Arg Ala Lys Trp Trp Phe Leu Gly Ala Leu Val Leu Leu Ser Ala Gly

10 15 20gct tat gcg tcg gtg ctg gtg ccg cag gtg ctg ggg cgg att gtg gat 211Ala Tyr Ala Ser Val Leu Val Pro Gln Val Leu Gly Arg Ile Val Asp

25 30 35ctg gtg tcc gat ggc gcg cag atg cgt gat ttt gtt gag ctc agt gtg 259Leu Val Ser Asp Gly Ala Gln Met Arg Asp Phe Val Glu Leu Ser Val

40 45 50att ctc att gcg gtg gca att gcc ggc gcg gtg ctc agt gcg tgc ggg 307Ile Leu Ile Ala Val Ala Ile Ala Gly Ala Val Leu Ser Ala Cys Gly

55 60 65ttc tat gtg gtg tcg cgg att tct gag aag att atc gcc aat ttg agg 355Phe Tyr Val Val Ser Arg Ile Ser Glu Lys Ile Ile Ala Asn Leu Arg 70 75 80 85gaa gat atg gtg ggc acc gcg ctt ggg ttg ccc acg cac cag gtg gaa 403Glu Asp Met Val Gly Thr Ala Leu Gly Leu Pro Thr His Gln Val Glu

90 95 100gat gcg ggc tct ggc gat ttg gtg agc cgc tcc acc gat gat gtc tcc 451Asp Ala Gly Ser Gly Asp Leu Val Ser Arg Ser Thr Asp Asp Val Ser

105 110 115gag cta tcc gca gcg gtg aca gag acc gtc ccg att tta agt tcc tca 499Glu Leu Ser Ala Ala Val Thr Glu Thr Val Pro Ile Leu Ser Ser Ser

120 125 130ctg ttt acc att gcc gcg acg atc att gcg ctg ttt tct ttg gac tgg 547Leu Phe Thr Ile Ala Ala Thr Ile Ile Ala Leu Phe Ser Leu Asp Trp

135 140 145caa ttt gtg ctc att cct gtc gtg gtg gcg ccg gtg tac tac ttc gcg 595Gln Phe Val Leu Ile Pro Val Val Val Ala Pro Val Tyr Tyr Phe Ala150 155 160 165tcc aag cac tat ttg agc aag gcg ccg gat cgg tat gcg gca gaa cgc 643Ser Lys His Tyr Leu Ser Lys Ala Pro Asp Arg Tyr Ala Ala Glu Arg

170 175 180gcg gcg atg gcg gag cgt gcg cga aag gta ctt gag gct att cgc ggg 691Ala Ala Met Ala Glu Arg Ala Arg Lys Val Leu Glu Ala Ile Arg Gly

185 190 195cgt gca act gtg cgg gcg tat tcc atg gaa gat gcc atg cat aat cag 739Arg Ala Thr Val Arg Ala Tyr Ser Met Glu Asp Ala Met His Asn Gln

200 205 210att gat cag gcg tcg tgg tct gtg gtg gtc aag ggt att cgt gcg cgc 787Ile Asp Gln Ala Ser Trp Ser Val Val Val Lys Gly Ile Arg Ala Arg

215 220 225acc acc atg ttg att ttg aac atg tgg atg ctg ttt gcg gaa ttc ctc 835Thr Thr Met Leu Ile Leu Asn Met Trp Met Leu Phe Ala Glu Phe Leu230 235 240 245atg ctc gcg gtc gcg ttg gtg atc ggc tac aag ctg gtc att gat aat 883Met Leu Ala Val Ala Leu Val Ile Gly Tyr Lys Leu Val Ile Asp Asn

250 255 260gcg ctg acg atc ggc gcg gtt acc ggt gcc gtg ctg atg att att cgt 931Ala Leu Thr Ile Gly Ala Val Thr Gly Ala Val Leu Met Ile Ile Arg

265 270 275ctg cgt ggc ccg atg aat atg ttc atg cgc gtg ctc gac acc att caa 979Leu Arg Gly Pro Met Asn Met Phe Met Arg Val Leu Asp Thr Ile Gln

280 285 290tcc ggc tat gcg tcg ctg gcg cgc atc gtg gga gtt gtt gcg gat ccg 1027Ser Gly Tyr Ala Ser Leu Ala Arg Ile Val Gly Val Val Ala Asp Pro

295 300 305ccg att cct gtg ccc gac agc ggt gtg aaa gca cct cag ggc aaa gtg 1075Pro Ile Pro Val Pro Asp Ser Gly Val Lys Ala Pro Gln Gly Lys Val310 315 320 325gaa ttg cgc aac gtc agc ttt agc tat ggc gat tcc tgg gcg gtg aaa 1123Glu Leu Arg Asn Val Ser Phe Ser Tyr Gly Asp Ser Trp Ala Val Lys

330 335 340gac atc gac atc acg atc aat tcc ggc gaa act gtc gcg ctc gtg ggc 1171Asp Ile Asp Ile Thr Ile Asn Ser Gly Glu Thr Val Ala Leu Val Gly

345 350 355gca tct ggc gca ggt aag acg acg gtc gcc gcc ttg ctg gcg ggc ttg 1219Ala Ser Gly Ala Gly Lys Thr Thr Val Ala Ala Leu Leu Ala Gly Leu

360 365 370cgg gtg cca gat caa ggg caa gtg ctt gtc gac gac ttc ccc gtc tct 1267Arg Val Pro Asp Gln Gly Gln Val Leu Val Asp Asp Phe Pro Val Ser

375 380 385cac ctc tct gac cgc gag cgt atc gcc cgc ttg gcc atg gtc agc cag 1315His Leu Ser Asp Arg Glu Arg Ile Ala Arg Leu Ala Met Val Ser Gln390 395 400 405gag gtt cat gtt ttc tcc ggc acg ctg cgc cag gat ctc acc ttg gct 1363Glu Val His Val Phe Ser Gly Thr Leu Arg Gln Asp Leu Thr Leu Ala

410 415 420aaa cca gat gcc tcc gat gag gaa tta gcg cat gct ctt ggg caa gtt 1411Lys Pro Asp Ala Ser Asp Glu Glu Leu Ala His Ala Leu Gly Gln Val

425 430 435aat gcc ctt gac tgg ttg gag agt ctt cca gaa gga ctg gac acg gtc 1459Asn Ala Leu Asp Trp Leu Glu Ser Leu Pro Glu Gly Leu Asp Thr Val

440 445 450gtt ggt gcg cga gga atc cag cta gaa cca gtg gtg gct cag cag ttg 1507Val Gly Ala Arg Gly Ile Gln Leu Glu Pro Val Val Ala Gln Gln Leu

455 460 465gcg ttg gcc cgg gtg ttg ttg ctc aat ccg gcg atc gtc atc atg gat 1555Ala Leu Ala Arg Val Leu Leu Leu Asn Pro Ala Ile Val Ile Met Asp470 475 480 485gaa gcc acg gca gaa gca gga tcg gcg ggt gcc agc gca ctg gaa gag 1603Glu Ala Thr Ala Glu Ala Gly Ser Ala Gly Ala Ser Ala Leu Glu Glu

490 495 500gct gca gat gca gtg agc aag aac cgt tcc gca ttg gtg gtg gcg cac 1651Ala Ala Asp Ala Val Ser Lys Asn Arg Ser Ala Leu Val Val Ala His

505 510 515cgg ttg gat cag gca tcg cgg gct gat cag att ctg gtg atg gat aag 1699Arg Leu Asp Gln Ala Ser Arg Ala Asp Gln Ile Leu Val Met Asp Lys

520 525 530ggg gag gtt gtg gaa tcc ggt act cac cag gag tta ttg gat cac ggg 1747Gly Glu Val Val Glu Ser Gly Thr His Gln Glu Leu Leu Asp His Gly

535540545 ggt att tat cag cgt ctg tgg act gcg tgg agtgtc gga aga 1789Gly Ile Tyr Gln Arg Leu Trp Thr Ala Trp Ser Val Gly Arg 550555560 taggttgactg ttcaatgcgt tga 1812<210>254<211>563<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>254Val Gly Arg Ile Pro Arg Ala Lys Trp Trp Phe Leu Gly Ala Leu Val 151015 Leu Leu Ser Ala Gly Ala Tyr Ala Ser Val Leu Val Pro Gln Val Leu

20 25 30Gly Arg Ile Val Asp Leu Val Ser Asp Gly Ala Gln Met Arg Asp Phe

35 40 45Val Glu Leu Ser Val Ile Leu Ile Ala Val Ala Ile Ala Gly Ala Val

50 55 60Leu Ser Ala Cys Gly Phe Tyr Val Val Ser Arg Ile Ser Glu Lys Ile65 70 75 80Ile Ala Asn Leu Arg Glu Asp Met Val Gly Thr Ala Leu Gly Leu Pro

85 90 95Thr His Gln Val Glu Asp Ala Gly Ser Gly Asp Leu Val Ser Arg Ser

100 105 110Thr Asp Asp Val Ser Glu Leu Ser Ala Ala Val Thr Glu Thr Val Pro

115 120 125Ile Leu Ser Ser Ser Leu Phe Thr Ile Ala Ala Thr Ile Ile Ala Leu

130 135 140Phe Ser Leu Asp Trp Gln Phe Val Leu Ile Pro Val Val Val Ala Pro145 150 155 160Val Tyr Tyr Phe Ala Ser Lys His Tyr Leu Ser Lys Ala Pro Asp Arg

165 170 175Tyr Ala Ala Glu Arg Ala Ala Met Ala Glu Arg Ala Arg Lys Val Leu

180 185 190Glu Ala Ile Arg Gly Arg Ala Thr Val Arg Ala Tyr Ser Met Glu Asp

195 200205Ala Met His Asn Gln Ile Asp Gln Ala Ser Trp Ser Val Val Val Lys

210 215 220Gly Ile Arg Ala Arg Thr Thr Met Leu Ile Leu Asn Met Trp Met Leu225 230 235 240Phe Ala Glu Phe Leu Met Leu Ala Val Ala Leu Val Ile Gly Tyr Lys

245 250 255Leu Val Ile Asp Asn Ala Leu Thr Ile Gly Ala Val Thr Gly Ala Val

260 265 270Leu Met Ile Ile Arg Leu Arg Gly Pro Met Asn Met Phe Met Arg Val

275 280 285Leu Asp Thr Ile Gln Ser Gly Tyr Ala Ser Leu Ala Arg Ile Val Gly

290 295 300Val Val Ala Asp Pro Pro Ile Pro Val Pro Asp Ser Gly Val Lys Ala305 310 315 320Pro Gln Gly Lys Val Glu Leu Arg Asn Val Ser Phe Ser Tyr Gly Asp

325 330 335Ser Trp Ala Val Lys Asp Ile Asp Ile Thr Ile Asn Ser Gly Glu Thr

340 345 350Val Ala Leu Val Gly Ala Ser Gly Ala Gly Lys Thr Thr Val Ala Ala

355 360 365Leu Leu Ala Gly Leu Arg Val Pro Asp Gln Gly Gln Val Leu Val Asp

370 375 380Asp Phe Pro Val Ser His Leu Ser Asp Arg Glu Arg Ile Ala Arg Leu385 390 395 400Ala Met Val Ser Gln Glu Val His Val Phe Ser Gly Thr Leu Arg Gln

405 410 415Asp Leu Thr Leu Ala Lys Pro Asp Ala Ser Asp Glu Glu Leu Ala His

420 425430Ala Leu Gly Gln Val Asn Ala Leu Asp Trp Leu Glu Ser Leu Pro Glu

435 440 445Gly Leu Asp Thr Val Val Gly Ala Arg Gly Ile Gln Leu Glu Pro Val

450 455 460Val Ala Gln Gln Leu Ala Leu Ala Arg Val Leu Leu Leu Asn Pro Ala465 470 475 480Ile Val Ile Met Asp Glu Ala Thr Ala Glu Ala Gly Ser Ala Gly Ala

485 490 495Ser Ala Leu Glu Glu Ala Ala Asp Ala Val Ser Lys Asn Arg Ser Ala

500 505 510Leu Val Val Ala His Arg Leu Asp Gln Ala Ser Arg Ala Asp Gln Ile

515 520 525Leu Val Met Asp Lys Gly Glu Val Val Glu Ser Gly Thr His Gln Glu

530535540 Leu Leu Asp His Gly Gly Ile Tyr Gln Arg Leu Trp Thr Ala Trp Ser 545550555560 Val Gly Arg<210>255<211>1713<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1690)<223>RXC01191<400>255cgctgctttc acgcaactga aaccgcaccg gatcaagtta tttggggttg ttctttgtgg 60cgtgttggtg gccgtcgcgg ggttggtagg gccctgggcg gtg ggt gga ctc gtc 115

Val Gly Gly Leu Val

1 5gat aag ctc ctt gca acc ccg agc atg cgc gac gtt gta gtg ttc gcg 163Asp Lys Leu Leu Ala Thr Pro Ser Met Arg Asp Val Val Val Phe Ala

10 15 20ctg ctt atc gtg gct ggc ggc gtt gtt tcg agc ctg ggc acg tgg tgg 211Leu Leu Ile Val Ala Gly Gly Val Val Ser Ser Leu Gly Thr Trp Trp

25 3035ggc agc gcg ctg atg gcg cgc gcg ttg gag ccg gcg atc gcg ggg ctg 259Gly Ser Ala Leu Met Ala Arg Ala Leu Glu Pro Ala Ile Ala Gly Leu

40 45 50cgc gag gat gtg ttg cgc gcg gcg gtg agt ttg gat gcg aac acg att 307Arg Glu Asp Val Leu Arg Ala Ala Val Ser Leu Asp Ala Asn Thr Ile

55 60 65gaa acg gcg ggg cgc ggc gac gtg att tcg cgt atc gcg gat gat tcg 355Glu Thr Ala Gly Arg Gly Asp Val Ile Ser Arg Ile Ala Asp Asp Ser 70 75 80 85cgg gag gtg tcc act gcg gcg agc acc gtg gtg ccg ctg atg gtg cag 403Arg Glu Val Ser Thr Ala Ala Ser Thr Val Val Pro Leu Met Val Gln

90 95 100gcg ggc ttt acc gtg gtg att tcc gcg ttt ggc atg gcg gcg gtt gat 451Ala Gly Phe Thr Val Val Ile Ser Ala Phe Gly Met Ala Ala Val Asp

105 110 115tgg cgc ctc ggc ctt gtc ggt ttg gtc gcg atc ccg ctg tat tgg acc 499Trp Arg Leu Gly Leu Val Gly Leu Val Ala Ile Pro Leu Tyr Trp Thr

120 125 130acg ttg cgc gtc tat tta ccc cgc tca ggt ccg ctt tat acg cgt gag 547Thr Leu Arg Val Tyr Leu Pro Arg Ser Gly Pro Leu Tyr Thr Arg Glu

135 140 145cgc gag gcc ttt ggg gtg cgc acg cag cgg ctt gtc ggc gca gtc gaa 595Arg Glu Ala Phe Gly Val Arg Thr Gln Arg Leu Val Gly Ala Val Glu150 155 160 165ggc gcg gaa acc ttg cgc gct ttc cgc gca gaa gat aca gaa tta aag 643Gly Ala Glu Thr Leu Arg Ala Phe Arg Ala Glu Asp Thr Glu Leu Lys

170 175 180cgt atc gac gca gcc tcc ggc gaa gcc cgc gac att tcc att tct gtt 691Arg Ile Asp Ala Ala Ser Gly Glu AlaArg Asp Ile Ser Ile Ser Val

185 190 195ttc agg ttc ctc aca tgg gca ttt tcc cgc aac aac cgc gcg gaa tgc 739Phe Arg Phe Leu Thr Trp Ala Phe Ser Arg Asn Asn Arg Ala Glu Cys

200 205 210atc acc ctc gtg ctc atc ttg ggc acc ggc ttt tac ctg gtc aac atc 787Ile Thr Leu Val Leu Ile Leu Gly Thr Gly Phe Tyr Leu Val Asn Ile

215 220 225gat ctg gtc acc gtc ggc gca gtc tca acc gcc gca ctg atc ttc cac 835Asp Leu Val Thr Val Gly Ala Val Ser Thr Ala Ala Leu Ile Phe His230 235 240 245cga ctc ttc ggt cca atc ggc acg ctc gtg ggc atg ttc tcc gac atc 883Arg Leu Phe Gly Pro Ile Gly Thr Leu Val Gly Met Phe Ser Asp Ile

250 255 260caa tcc gcc agc gca tcg ctg atc cgc atg gtg ggc gtt att aac gcg 931Gln Ser Ala Ser Ala Ser Leu Ile Arg Met Val Gly Val Ile Asn Ala

265 270 275gca tcg aac cag gtc agc ggc acc tcg ccg gcg tct gcc agc acc gct 979Ala Ser Asn Gln Val Ser Gly Thr Ser Pro Ala Ser Ala Ser Thr Ala

280 285 290tta acg ctt ttc gac gtc tcc cac cac tat cac act gca ccc gtc atc 1027Leu Thr Leu Phe Asp Val Ser His His Tyr His Thr Ala Pro Val Ile

295 300 305aag aat gca tcc gtg cag ctg gaa cca ggg gaa cac atc gcc att gtg 1075Lys Asn Ala Ser Val Gln Leu Glu Pro Gly Glu His Ile Ala Ile Val310 315 320 325ggt gcg acc ggc gct ggt aaa agc acg ctc gcc ctc att gcg gca ggc 1123Gly Ala Thr Gly Ala Gly Lys Ser Thr Leu Ala Leu Ile Ala Ala Gly

330 335 340ctg ctc agc cca act tcc ggg cag gtg gct ctc ggc gga tcg agt ttt 1171Leu Leu Ser Pro Thr Ser Gly Gln Val Ala Leu Gly Gly Ser Ser Phe

345 350 355tct aac gtc gaa ccg gaa gca ttg cgc cag aag atc gcg atg gtc agc 1219Ser Asn Val Glu Pro Glu Ala Leu Arg Gln Lys Ile Ala Met Val Ser

360 365 370caa gaa atc cac tgc ttc cga gga tct gtt tta gat aat ctt cgt atc 1267Gln Glu Ile His Cys Phe Arg Gly Ser Val Leu Asp Asn Leu Arg Ile

375 380 385gca cgc ccc gaa gcc acc gat gcg gac atc cac gcc gtt ctc gcc gat 1315Ala Arg Pro Glu Ala Thr Asp Ala Asp Ile His Ala Val Leu Ala Asp390 395 400 405att ggt gat tcc tgg ttg gag cgc tta ccg caa ggc ata gac acc atc 1363Ile Gly Asp Ser Trp Leu Glu Arg Leu Pro Gln Gly Ile Asp Thr Ile

410 415 420gtg ggt gat ggc gct ttc cgt tta acc tct gtg gaa aac cag atc atg 1411Val Gly Asp Gly Ala Phe Arg Leu Thr Ser Val Glu Asn Gln Ile Met

425 430 435gcg ctt gct cgc gta cat ttg gcc gac cta gca atc gtc atc ctt gat 1459Ala Leu Ala Arg Val His Leu Ala Asp Leu Ala Ile Val Ile Leu Asp

440 445 450gaa gca acg gct gaa tca ggc tct gat cat gca aaa cag ctt gaa gat 1507Glu Ala Thr Ala Glu Ser Gly Ser Asp His Ala Lys Gln Leu Glu Asp

455 460 465gca gcc ctt aaa gtc act gaa aac aga tca gcc atc atc gtg gct cac 1555Ala Ala Leu Lys Val Thr Glu Asn Arg Ser Ala Ile Ile Val Ala His470 475 480 485cgc ctc aac caa gcg aaa acc gcc gat cgc atc atc gtc atg gac tcc 1603Arg Leu Asn Gln Ala Lys Thr Ala Asp ArgIle Ile Val Met Asp Ser

490 495 500gga gaa atc ata gaa tct gga acc cat gaa gag ctt cga gcg atc ggc 1651Gly Glu Ile Ile Glu Ser Gly Thr His Glu Glu Leu Arg Ala Ile Gly

505 510 515ggc cga tat gaa caa ctg tgg act gcg tgg tct gcg cgc taattagcca 1700Gly Arg Tyr Glu Gln Leu Trp Thr Ala Trp Ser Ala Arg

520525530 cccaagacca cgc 1713<210>256<211>530<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>256Val Gly Gly Leu Val Asp Lys Leu Leu Ala Thr Pro Ser Met Arg Asp 151015 Val Val Val Phe Ala Leu Leu Ile Val Ala Gly Gly Val Val Ser Ser

20 25 30Leu Gly Thr Trp Trp Gly Ser Ala Leu Met Ala Arg Ala Leu Glu Pro

35 40 45Ala Ile Ala Gly Leu Arg Glu Asp Val Leu Arg Ala Ala Val Ser Leu

50 55 60Asp Ala Asn Thr Ile Glu Thr Ala Gly Arg Gly Asp Val Ile Ser Arg 65 70 75 80Ile Ala Asp Asp Ser Arg Glu Val Ser Thr Ala Ala Ser Thr Val Val

85 90 95Pro Leu Met Val Gln Ala Gly Phe Thr Val Val Ile Ser Ala Phe Gly

100 105 110Met Ala Ala Val Asp Trp Arg Leu Gly Leu Val Gly Leu Val Ala Ile

115 120 125Pro Leu Tyr Trp Thr Thr Leu Arg Val Tyr Leu Pro Arg Ser Gly Pro

130 135 140Leu Tyr Thr Arg Glu Arg Glu Ala Phe Gly Val Arg Thr Gln Arg Leu145 150 155 160ValGly Ala Val Glu Gly Ala Glu Thr Leu Arg Ala Phe Arg Ala Glu

165 170 175Asp Thr Glu Leu Lys Arg Ile Asp Ala Ala Ser Gly Glu Ala Arg Asp

180 185 190Ile Ser Ile Ser Val Phe Arg Phe Leu Thr Trp Ala Phe Ser Arg Asn

195 200 205Asn Arg Ala Glu Cys Ile Thr Leu Val Leu Ile Leu Gly Thr Gly Phe

210 215 220Tyr Leu Val Asn Ile Asp Leu Val Thr Val Gly Ala Val Ser Thr Ala225 230 235 240Ala Leu Ile Phe His Arg Leu Phe Gly Pro Ile Gly Thr Leu Val Gly

245 250 255Met Phe Ser Asp Ile Gln Ser Ala Ser Ala Ser Leu Ile Arg Met Val

260 265 270Gly Val Ile Asn Ala Ala Ser Asn Gln Val Ser Gly Thr Ser Pro Ala

275 280 285Ser Ala Ser Thr Ala Leu Thr Leu Phe Asp Val Ser His His Tyr His

290 295 300Thr Ala Pro Val Ile Lys Asn Ala Ser Val Gln Leu Glu Pro Gly Glu305 310 315 320His Ile Ala Ile Val Gly Ala Thr Gly Ala Gly Lys Ser Thr Leu Ala

325 330 335Leu Ile Ala Ala Gly Leu Leu Ser Pro Thr Ser Gly Gln Val Ala Leu

340 345 350Gly Gly Ser Ser Phe Ser Asn Val Glu Pro Glu Ala Leu Arg Gln Lys

355 360 365Ile Ala Met Val Ser Gln Glu Ile His Cys Phe Arg Gly Ser Val Leu

370 375 380Asp Asn Leu Arg Ile Ala Arg Pro Glu Ala Thr Asp Ala Asp Ile His385 390 395 400Ala Val Leu Ala Asp Ile Gly Asp Ser Trp Leu Glu Arg Leu Pro Gln

405 410 415Gly Ile Asp Thr Ile Val Gly Asp Gly Ala Phe Arg Leu Thr Ser Val

420 425 430Glu Asn Gln Ile Met Ala Leu Ala Arg Val His Leu Ala Asp Leu Ala

435 440 445Ile Val Ile Leu Asp Glu Ala Thr Ala Glu Ser Gly Ser Asp His Ala

450 455 460Lys Gln Leu Glu Asp Ala Ala Leu Lys Val Thr Glu Asn Arg Ser Ala465 470 475 480Ile Ile Val Ala His Arg Leu Asn Gln Ala Lys Thr Ala Asp Arg Ile

485 490 495Ile Val Met Asp Ser Gly Glu Ile Ile Glu Ser Gly Thr His Glu Glu

500 505 510Leu Arg Ala Ile Gly Gly Arg Tyr Glu Gln Leu Trp Thr Ala Trp Ser

515 520 525Ala Arg

530<210>257<211>1392<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1369)<223>RXA02646<400>257ttggaaataa aacctatgcc aaagtaggtg caattctagg agaagattac actagtcaac 60catgagtgaa acatacgtgt ctgagaaaag tccaggagtg atg gct agc gga gcg 115

Met Ala Ser Gly Ala

1 5gag ctg att cgt gcc gcc gac att caa acg gcg cag gca cga att tcc 163Glu Leu Ile Arg Ala Ala Asp Ile Gln Thr Ala Gln Ala Arg Ile Ser

10 15 20tcc gtc att gca cca act cca ttg cag tat tgc cct cgt ctt tct gag 211Ser Val Ile Ala Pro Thr Pro Leu Gln Tyr Cys Pro Arg Leu Ser Glu

25 30 35gaa acc gga gcg gaa atc tac ctt aag cgt gag gat ctg cag gat gtt 259Glu Thr Gly Ala Glu Ile Tyr Leu Lys Arg Glu Asp Leu Gln Asp Val

40 45 50cgt tcc tac aag atc cgc ggt gcg ctg aac tct gga gcg cag ctc acc 307Arg Ser Tyr Lys Ile Arg Gly Ala Leu Asn Ser Gly Ala Gln Leu Thr

55 60 65caa gag cag cgc gat gca ggt atc gtt gcc gca tct gca ggt aac cat 355Gln Glu Gln Arg Asp Ala Gly Ile Val Ala Ala Ser Ala Gly Asn His 70 75 80 85gcc cag ggc gtg gcc tat gtg tgc aag tcc ttg ggc gtt cag gga cgc 403Ala Gln Gly Val Ala Tyr Val Cys Lys Ser Leu Gly Val Gln Gly Arg

90 95 100atc tat gtt cct gtg cag act cca aag caa aag cgt gac cgc atc atg 451Ile Tyr Val Pro Val Gln Thr Pro Lys Gln Lys Arg Asp Arg Ile Met

105 110 115gtt cac ggc gga gag ttt gtc tcc ttg gtg gtc act ggc aat aac ttc 499Val His Gly Gly Glu Phe Val Ser Leu Val Val Thr Gly Asn Asn Phe

120 125 130gac gaa gca tcg gct gca gcg cat gaa gat gca gag cgc acc ggc gca 547Asp Glu Ala Ser Ala Ala Ala His Glu Asp Ala Glu Arg Thr Gly Ala

135 140 145acg ctg atc gag cct ttc gat gct cgc aac acc gtc atc ggt cag ggc 595Thr Leu Ile Glu Pro Phe Asp Ala Arg Asn Thr Val Ile Gly Gln Gly150 155 160 165acc gtg gct gct gag atc ttg tcg cag ctg act tcc atg ggc aagagt 643Thr Val Ala Ala Glu Ile Leu Ser Gln Leu Thr Ser Met Gly Lys Ser

170 175 180gca gat cac gtg atg gtt cca gtc ggc ggt ggc gga ctt ctt gca ggt 691Ala Asp His Val Met Val Pro Val Gly Gly Gly Gly Leu Leu Ala Gly

185 190 195gtg gtc agc tac atg gct gat atg gca cct cgc act gcg atc gtt ggt 739Val Val Ser Tyr Met Ala Asp Met Ala Pro Arg Thr Ala Ile Val Gly

200 205 210atc gaa cca gcg gga gca gca tcc atg cag gct gca ttg cac aat ggt 787Ile Glu Pro Ala Gly Ala Ala Ser Met Gln Ala Ala Leu His Asn Gly

215 220 225gga cca atc act ttg gag act gtt gat ccc ttt gtg gac ggc gca gca 835Gly Pro Ile Thr Leu Glu Thr Val Asp Pro Phe Val Asp Gly Ala Ala230 235 240 245gtc aaa cgt gtc gga gat ctc aac tac acc atc gtg gag aag aac cag 883Val Lys Arg Val Gly Asp Leu Asn Tyr Thr Ile Val Glu Lys Asn Gln

250 255 260ggt cgc gtg cac atg atg agc gcg acc gag ggc gct gtg tgt act gag 931Gly Arg Val His Met Met Ser Ala Thr Glu Gly Ala Val Cys Thr Glu

265 270 275atg ctc gat ctt tac caa aac gaa ggc atc atc gcg gag cct gct ggc 979Met Leu Asp Leu Tyr Gln Asn Glu Gly Ile Ile Ala Glu Pro Ala Gly

280 285 290gcg ctg tct atc gct ggg ttg aag gaa atg tcc ttt gca gct cgc tct 1027Ala Leu Ser Ile Ala Gly Leu Lys Glu Met Ser Phe Ala Ala Arg Ser

295 300 305gtc gtg gtg tgc atc atc tct ggt ggc aac aac gat gtg ctg cgt tat 1075Val Val Val Cys Ile Ile Ser Gly Gly Asn Asn Asp Val Leu Arg Tyr310315 320 325gcg gaa atc gct gag cgc tcc ttg gtg cgc cgc ggt tta aag cac tac 1123Ala Glu Ile Ala Glu Arg Ser Leu Val Arg Arg Gly Leu Lys His Tyr

330 335 340ttc ttg gtg aac ttc ccg caa aag cct ggt cag ttg cgt cac ttc ctg 1171Phe Leu Val Asn Phe Pro Gln Lys Pro Gly Gln Leu Arg His Phe Leu

345 350 355gaa gat atc ctg gga ccg gat gat gac atc acg ctg ttt gag tac ctc 1219Glu Asp Ile Leu Gly Pro Asp Asp Asp Ile Thr Leu Phe Glu Tyr Leu

360 365 370aag cgc aac aac cgt gag acc ggt act gcg ttg gtg ggt att cac ttg 1267Lys Arg Asn Asn Arg Glu Thr Gly Thr Ala Leu Val Gly Ile His Leu

375 380 385agt gaa gca tca gga ttg gat tct ttg ctg gaa cgt atg gag gaa tcg 1315Ser Glu Ala Ser Gly Leu Asp Ser Leu Leu Glu Arg Met Glu Glu Ser390 395 400 405gca att gat tcc cgt cgc ctc gag ccg ggc acc cct gag tac gaa tac 1363Ala Ile Asp Ser Arg Arg Leu Glu Pro Gly Thr Pro Glu Tyr Glu Tyr

410415420 ttg acc taaacatagc tgaaggccac ctc 1392Leu Thr<210>258<211>423<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>258Met Ala Ser Gly Ala Glu Leu Ile Arg Ala Ala Asp Ile Gln Thr Ala 151015 Gln Ala Arg Ile Ser Ser Val Ile Ala Pro Thr Pro Leu Gln Tyr Cys

20 25 30Pro Arg Leu Ser Glu Glu Thr Gly Ala Glu Ile Tyr Leu Lys Arg Glu

35 40 45Asp Leu Gln Asp Val Arg Ser Tyr Lys Ile Arg Gly Ala Leu Asn Ser

50 55 60Gly Ala Gln Leu Thr Gln Glu Gln Arg Asp Ala Gly Ile Val Ala Ala 65 70 75 80Ser Ala Gly Asn His Ala Gln Gly Val Ala Tyr Val Cys Lys Ser Leu

85 90 95Gly Val Gln Gly Arg Ile Tyr Val Pro Val Gln Thr Pro Lys Gln Lys

100 105 110Arg Asp Arg Ile Met Val His Gly Gly Glu Phe Val Ser Leu Val Val

115 120 125Thr Gly Asn Asn Phe Asp Glu Ala Ser Ala Ala Ala His Glu Asp Ala

130 135 140Glu Arg Thr Gly Ala Thr Leu Ile Glu Pro Phe Asp Ala Arg Asn Thr145 150 155 160Val Ile Gly Gln Gly Thr Val Ala Ala Glu Ile Leu Ser Gln Leu Thr

165 170 175Ser Met Gly Lys Ser Ala Asp His Val Met Val Pro Val Gly Gly Gly

180 185 190Gly Leu Leu Ala Gly Val Val Ser Tyr Met Ala Asp Met Ala Pro Arg

195 200 205Thr Ala Ile Val Gly Ile Glu Pro Ala Gly Ala Ala Ser Met Gln Ala

210 215 220Ala Leu His Asn Gly Gly Pro Ile Thr Leu Glu Thr Val Asp Pro Phe225 230 235 240Val Asp Gly Ala Ala Val Lys Arg Val Gly Asp Leu Asn Tyr Thr Ile

245 250 255Val Glu Lys Asn Gln Gly Arg Val His Met Met Ser Ala Thr Glu Gly

260 265 270Ala Val Cys Thr Glu Met Leu Asp Leu Tyr Gln Asn Glu Gly Ile Ile

275 280 285Ala Glu Pro Ala Gly Ala Leu Ser Ile Ala Gly Leu LysGlu Met Ser

290 295 300Phe Ala Ala Arg Ser Val Val Val Cys Ile Ile Ser Gly Gly Asn Asn305 310 315 320Asp Val Leu Arg Tyr Ala Glu Ile Ala Glu Arg Ser Leu Val Arg Arg

325 330 335Gly Leu Lys His Tyr Phe Leu Val Asn Phe Pro Gln Lys Pro Gly Gln

340 345 350Leu Arg His Phe Leu Glu Asp Ile Leu Gly Pro Asp Asp Asp Ile Thr

355 360 365Leu Phe Glu Tyr Leu Lys Arg Asn Asn Arg Glu Thr Gly Thr Ala Leu

370 375 380Val Gly Ile His Leu Ser Glu Ala Ser Gly Leu Asp Ser Leu Leu Glu385 390 395 400Arg Met Glu Glu Ser Ala Ile Asp Ser Arg Arg Leu Glu Pro Gly Thr

405 410 415Pro Glu Tyr Glu Tyr Leu Thr

420<210>259<211>966<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (943)<223>RXA00766<400>259tatggcgctt gaaccacaaa taaagtctgc accgacgccg gtgatcttaa ttgtcgaacc 60ctacggcggg tccatccggc aacaaaaccc caacctacca atg gtt ttt tgg gac 115

Met Val Phe Trp Asp

1 5gat gca gcc tta acc cga ggc gat ggc atc ttt gaa aca ctc ctc atc 163Asp Ala Ala Leu Thr Arg Gly Asp Gly Ile Phe Glu Thr Leu Leu Ile

10 15 20cgc gac gga cat gcc tgc aac gtg cgc cga cac gga gaa cgc ttc aaa 211Arg Asp Gly His Ala Cys Asn Val Arg Arg His Gly Glu Arg Phe Lys

25 30 35gca tcg gca gca cta ttg gga ctg cca gag ccg atc ctg gaa gac tgg 259Ala Ser Ala Ala Leu Leu Gly Leu Pro Glu Pro Ile Leu Glu Asp Trp

40 45 50gaa aaa gcc acc caa atg ggc atc gaa tcc tgg tac tcc cac ccc aac 307Glu Lys Ala Thr Gln Met Gly Ile Glu Ser Trp Tyr Ser His Pro Asn

55 60 65gca ggc gag gcc tca tgc acc tgg acg ctc agc cga ggt cgt tcc tcc 355Ala Gly Glu Ala Ser Cys Thr Trp Thr Leu Ser Arg Gly Arg Ser Ser 70 75 80 85acg ggg ctg gcc tca gga tgg tta acc atc acc cca gtc tcc tcc gac 403Thr Gly Leu Ala Ser Gly Trp Leu Thr Ile Thr Pro Val Ser Ser Asp

90 95 100aaa ctg gcg caa cgt gaa cac ggt gta tcg gtc atg acc agt tca aga 451Lys Leu Ala Gln Arg Glu His Gly Val Ser Val Met Thr Ser Ser Arg

105 110 115gga tat tcc atc gac acc ggc ctc ccc gga atc gga aaa gcc acc cga 499Gly Tyr Ser Ile Asp Thr Gly Leu Pro Gly Ile Gly Lys Ala Thr Arg

120 125 130ggc gag cta tct aaa gtg gaa cga acc ccc gca cca tgg ctg aca gtc 547Gly Glu Leu Ser Lys Val Glu Arg Thr Pro Ala Pro Trp Leu Thr Val

135 140 145ggc gcc aaa aca cta gcc tac gca gca aac atg gca gcc ctg cgc tac 595Gly Ala Lys Thr Leu Ala Tyr Ala Ala Asn Met Ala Ala Leu Arg Tyr150 155 160 165gcc aaa tca aac gga ttc gac gat gtg atc ttc acc gat ggc gac cgc 643Ala Lys Ser Asn Gly Phe Asp Asp Val Ile Phe Thr Asp Gly Asp Arg

170 175 180gtt cta gaa ggc gccacc tcc acc gta gtg agt ttc aaa ggc gac aaa 691Val Leu Glu Gly Ala Thr Ser Thr Val Val Ser Phe Lys Gly Asp Lys

185 190 195atc cgc acc cct tca ccc ggt ggc gac att ctc ccc gga acc acc caa 739Ile Arg Thr Pro Ser Pro Gly Gly Asp Ile Leu Pro Gly Thr Thr Gln

200 205 210gca gca ctc ttt gca cac gca acc gaa aaa gga tgg cga tgt aaa gaa 787Ala Ala Leu Phe Ala His Ala Thr Glu Lys Gly Trp Arg Cys Lys Glu

215 220 225aaa gac tta agc att gac gat ctt ttc gga gcc gac agc gtg tgg cta 835Lys Asp Leu Ser Ile Asp Asp Leu Phe Gly Ala Asp Ser Val Trp Leu230 235 240 245gtg tcc tcc gtc cgc gga cca gtt cgg gtg acc agg ctc gat gga cac 883Val Ser Ser Val Arg Gly Pro Val Arg Val Thr Arg Leu Asp Gly His

250 255 260aaa tta cgg aaa cca gac aat gaa aaa gaa atc aag gcg ctg att acc 931Lys Leu Arg Lys Pro Asp Asn Glu Lys Glu Ile Lys Ala Leu Ile Thr

265 270 275aaa gct ctg ggg tagaggctgg cgctgggact tgc 966Lys Ala Leu Gly

280<210>260<211>281<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>260Met Val Phe Trp Asp Asp Ala Ala Leu Thr Arg Gly Asp Gly Ile Phe 151015 Glu Thr Leu Leu Ile Arg Asp Gly His Ala Cys Asn Val Arg Arg His

20 25 30Gly Glu Arg Phe Lys Ala Ser Ala Ala Leu Leu Gly Leu Pro Glu Pro

35 40 45Ile Leu Glu Asp Trp Glu Lys Ala Thr Gln Met Gly Ile Glu Ser Trp

50 55 60Tyr Ser His Pro Asn Ala Gly Glu Ala Ser Cys Thr Trp Thr Leu Ser 65 70 75 80Arg Gly Arg Ser Ser Thr Gly Leu Ala Ser Gly Trp Leu Thr Ile Thr

85 90 95Pro Val Ser Ser Asp Lys Leu Ala Gln Arg Glu His Gly Val Ser Val

100 105 110Met Thr Ser Ser Arg Gly Tyr Ser Ile Asp Thr Gly Leu Pro Gly Ile

115 120 125Gly Lys Ala Thr Arg Gly Glu Leu Ser Lys Val Glu Arg Thr Pro Ala

130 135 140Pro Trp Leu Thr Val Gly Ala Lys Thr Leu Ala Tyr Ala Ala Asn Met145 150 155 160Ala Ala Leu Arg Tyr Ala Lys Ser Asn Gly Phe Asp Asp Val Ile Phe

165 170 175Thr Asp Gly Asp Arg Val Leu Glu Gly Ala Thr Ser Thr Val Val Ser

180 185 190Phe Lys Gly Asp Lys Ile Arg Thr Pro Ser Pro Gly Gly Asp Ile Leu

195 200 205Pro Gly Thr Thr Gln Ala Ala Leu Phe Ala His Ala Thr Glu Lys Gly

210 215 220Trp Arg Cys Lys Glu Lys Asp Leu Ser Ile Asp Asp Leu Phe Gly Ala225 230 235 240Asp Ser Val Trp Leu Val Ser Ser Val Arg Gly Pro Val Arg Val Thr

245 250 255Arg Leu Asp Gly His Lys Leu Arg Lys Pro Asp Asn Glu Lys Glu Ile

260 265 270Lys Ala Leu Ile Thr Lys Ala Leu Gly

275280<210>261<211>1224<212>DNA<213>Corynebacteriumglutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1201)<223>RXN01690<400>261cctagccatt cctcaaaacc gtgagacgaa attggctatt catcccataa aatggggctg 60actagtgtat ctgtcaggta gcaggtgtac cttaaaatcc atg acg tca tta gag 115

Met Thr Ser Leu Glu

1 5ttc aca gta acc cgt acc gaa aat ccg acg tca ccc gat cgt ctg aag 163Phe Thr Val Thr Arg Thr Glu Asn Pro Thr Ser Pro Asp Arg Leu Lys

10 15 20gaa att ctt gcc gca ccg aag ttc ggt aag ttc ttc acc gac cac atg 211Glu Ile Leu Ala Ala Pro Lys Phe Gly Lys Phe Phe Thr Asp His Met

25 30 35gtg acc att gac tgg aac gag tcg gaa ggc tgg cac aac gcc caa tta 259Val Thr Ile Asp Trp Asn Glu Ser Glu Gly Trp His Asn Ala Gln Leu

40 45 50gtg cca tac gcg ccg att cct atg gat cct gcc acc acc gta ttc cac 307Val Pro Tyr Ala Pro Ile Pro Met Asp Pro Ala Thr Thr Val Phe His

55 60 65tac gga cag gca att ttt gag gga att aag gcc tac cgc cat tcg gac 355Tyr Gly Gln Ala Ile Phe Glu Gly Ile Lys Ala Tyr Arg His Ser Asp 70 75 80 85gaa acc atc aag act ttc cgt cct gat gaa aac gcc gag cgt atg cag 403Glu Thr Ile Lys Thr Phe Arg Pro Asp Glu Asn Ala Glu Arg Met Gln

90 95 100cgt tca gca gct cga atg gca atg cca cag ttg cca acc gag gac ttt 451Arg Ser Ala Ala Arg Met Ala Met Pro Gln Leu Pro Thr Glu Asp Phe

105 110 115att aaa gca ctt gaa ctg ctg gta gac gcg gat cag gat tgg gtt cct499Ile Lys Ala Leu Glu Leu Leu Val Asp Ala Asp Gln Asp Trp Val Pro

120 125 130gag tac ggc gga gaa gct tcc ctc tac ctg cgc cca ttc atg atc tcc 547Glu Tyr Gly Gly Glu Ala Ser Leu Tyr Leu Arg Pro Phe Met Ile Ser

135 140 145acc gaa att ggc ttg ggt gtc agc cca gct gat gcc tac aag ttc ctg 595Thr Glu Ile Gly Leu Gly Val Ser Pro Ala Asp Ala Tyr Lys Phe Leu150 155 160 165gtc atc gca tcc cca gtc ggc gct tac ttc acc ggt gga atc aag cct 643Val Ile Ala Ser Pro Val Gly Ala Tyr Phe Thr Gly Gly Ile Lys Pro

170 175 180gtt tcc gtc tgg ctg agc gaa gat tac gtc cgc gct gca ccc ggc gga 691Val Ser Val Trp Leu Ser Glu Asp Tyr Val Arg Ala Ala Pro Gly Gly

185 190 195act ggt gac gcc aaa ttt gct ggc aac tac gcg gct tct ttg ctt gcc 739Thr Gly Asp Ala Lys Phe Ala Gly Asn Tyr Ala Ala Ser Leu Leu Ala

200 205 210cag tcc cag gct gcg gaa aag ggc tgt gac cag gtc gta tgg ttg gat 787Gln Ser Gln Ala Ala Glu Lys Gly Cys Asp Gln Val Val Trp Leu Asp

215 220 225gcc atc gag cac aag tac atc gaa gaa atg ggt ggc atg aac ctt ggg 835Ala Ile Glu His Lys Tyr Ile Glu Glu Met Gly Gly Met Asn Leu Gly230 235 240 245ttc atc tac cgc aac ggc gac caa gtc aag cta gtc acc cct gaa ctt 883Phe Ile Tyr Arg Asn Gly Asp Gln Val Lys Leu Val Thr Pro Glu Leu

250 255 260tcc ggc tca cta ctt cca ggc atc acc cgc aag tca ctt cta caa gta 931Ser Gly Ser Leu Leu Pro Gly Ile Thr Arg Lys Ser Leu Leu Gln Val

265270 275gca cgc gac ttg gga tac gaa gta gaa gag cga aag atc acc acc acc 979Ala Arg Asp Leu Gly Tyr Glu Val Glu Glu Arg Lys Ile Thr Thr Thr

280 285 290gag tgg gaa gaa gac gca aag tct ggc gcc atg acc gag gca ttt gct 1027Glu Trp Glu Glu Asp Ala Lys Ser Gly Ala Met Thr Glu Ala Phe Ala

295 300 305tgc ggt act gca gct gtt atc acc cct gtt ggc acc gtg aaa tca gct 1075Cys Gly Thr Ala Ala Val Ile Thr Pro Val Gly Thr Val Lys Ser Ala310 315 320 325cac ggc acc ttc gaa gtg aac aac aat gaa gtc gga gaa atc acg atg 1123His Gly Thr Phe Glu Val Asn Asn Asn Glu Val Gly Glu Ile Thr Met

330 335 340aag ctt cgt gaa acc ctc acc gga att cag caa gga aac gtt gaa gac 1171Lys Leu Arg Glu Thr Leu Thr Gly Ile Gln Gln Gly Asn Val Glu Asp

345 350 355caa aac gga tgg ctt tac cca ctg gtt ggc taaatcaacc ggttttaaga 1221Gln Asn Gly Trp Leu Tyr Pro Leu Val Gly

360365 ccc 1224<210>262<211>367<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>262Met Thr Ser Leu Glu Phe Thr Val Thr Arg Thr Glu Asn Pro Thr Ser 151015 Pro Asp Arg Leu Lys Glu Ile Leu Ala Ala Pro Lys Phe Gly Lys Phe

20 25 30Phe Thr Asp His Met Val Thr Ile Asp Trp Asn Glu Ser Glu Gly Trp

35 40 45His Asn Ala Gln Leu Val Pro Tyr Ala Pro Ile Pro Met Asp Pro Ala

50 55 60Thr Thr Val Phe His Tyr Gly Gln Ala Ile Phe Glu Gly Ile Lys Ala 65 70 7580Tyr Arg His Ser Asp Glu Thr Ile Lys Thr Phe Arg Pro Asp Glu Asn

85 90 95Ala Glu Arg Met Gln Arg Ser Ala Ala Arg Met Ala Met Pro Gln Leu

100 105 110Pro Thr Glu Asp Phe Ile Lys Ala Leu Glu Leu Leu Val Asp Ala Asp

115 120 125Gln Asp Trp Val Pro Glu Tyr Gly Gly Glu Ala Ser Leu Tyr Leu Arg

130 135 140Pro Phe Met Ile Ser Thr Glu Ile Gly Leu Gly Val Ser Pro Ala Asp145 150 155 160Ala Tyr Lys Phe Leu Val Ile Ala Ser Pro Val Gly Ala Tyr Phe Thr

165 170 175Gly Gly Ile Lys Pro Val Ser Val Trp Leu Ser Glu Asp Tyr Val Arg

180 185 190Ala Ala Pro Gly Gly Thr Gly Asp Ala Lys Phe Ala Gly Asn Tyr Ala

195 200 205Ala Ser Leu Leu Ala Gln Ser Gln Ala Ala Glu Lys Gly Cys Asp Gln

210 215 220Val Val Trp Leu Asp Ala Ile Glu His Lys Tyr Ile Glu Glu Met Gly225 230 235 240Gly Met Asn Leu Gly Phe Ile Tyr Arg Asn Gly Asp Gln Val Lys Leu

245 250 255Val Thr Pro Glu Leu Ser Gly Ser Leu Leu Pro Gly Ile Thr Arg Lys

260 265 270Ser Leu Leu Gln Val Ala Arg Asp Leu Gly Tyr Glu Val Glu Glu Arg

275 280 285Lys Ile Thr Thr Thr Glu Trp Glu Glu Asp Ala Lys Ser Gly Ala Met

290 295300Thr Glu Ala Phe Ala Cys Gly Thr Ala Ala Val Ile Thr Pro Val Gly305 310 315 320Thr Val Lys Ser Ala His Gly Thr Phe Glu Val Asn Asn Asn Glu Val

325 330 335Gly Glu Ile Thr Met Lys Leu Arg Glu Thr Leu Thr Gly Ile Gln Gln

340 345 350Gly Asn Val Glu Asp Gln Asn Gly Trp Leu Tyr Pro Leu Val Gly

355360365<210>263<211>1076<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (1053)<223>FRXA01690<400>263ccc gat cgt ctg aag gaa att ctt gcc gca ccg aag ttc ggt aag ttc 48Pro Asp Arg Leu Lys Glu Ile Leu Ala Ala Pro Lys Phe Gly Lys Phe 151015 ttc acc gac cac atg gtg acc att gac tgg aac gag tcg gaa ggc tgg 96Phe Thr Asp His Met Val Thr Ile Asp Trp Asn Glu Ser Glu Gly Trp

20 25 30cac aac gcc caa tta gtg cca tac gcg ccg att cct atg gat cct gcc 144His Asn Ala Gln Leu Val Pro Tyr Ala Pro Ile Pro Met Asp Pro Ala

35 40 45acc acc gta ttc cac tac gga cag gca att ttt gag gga att aag gcc 192Thr Thr Val Phe His Tyr Gly Gln Ala Ile Phe Glu Gly Ile Lys Ala

50 55 60tac cgc cat tcg gac gaa acc atc aag act ttc cgt cct gat gaa aac 240Tyr Arg His Ser Asp Glu Thr Ile Lys Thr Phe Arg Pro Asp Glu Asn 65 70 75 80gcc gag cgt atg cag cgt tca gca gct cga atg gca atg cca cag ttg 288Ala Glu Arg Met Gln Arg Ser Ala Ala Arg Met Ala Met Pro Gln Leu

85 90 95cca acc gag gac ttt att aaa gca ctt gaa ctg ctg gta gac gcg gat 336Pro Thr Glu Asp Phe Ile Lys Ala Leu Glu Leu Leu Val Asp Ala Asp

100 105 110cag gat tgg gtt cct gag tac ggc gga gaa gct tcc ctc tac ctg cgc 384Gln Asp Trp Val Pro Glu Tyr Gly Gly Glu Ala Ser Leu Tyr Leu Arg

115 120 125cca ttc atg atc tcc acc gaa att ggc ttg ggt gtc agc cca gct gat 432Pro Phe Met Ile Ser Thr Glu Ile Gly Leu Gly Val Ser Pro Ala Asp

130 135 140gcc tac aag ttc ctg gtc atc gca tcc cca gtc ggc gct tac ttc acc 480Ala Tyr Lys Phe Leu Val Ile Ala Ser Pro Val Gly Ala Tyr Phe Thr145 150 155 160ggt gga atc aag cct gtt tcc gtc tgg ctg agc gaa gat tac gtc cgc 528Gly Gly Ile Lys Pro Val Ser Val Trp Leu Ser Glu Asp Tyr Val Arg

165 170 175gct gca ccc ggc gga act ggt gac gcc aaa ttt gct ggc aac tac gcg 576Ala Ala Pro Gly Gly Thr Gly Asp Ala Lys Phe Ala Gly Asn Tyr Ala

180 185 190gct tct ttg ctt gcc cag tcc cag gct gcg gaa aag ggc tgt gac cag 624Ala Ser Leu Leu Ala Gln Ser Gln Ala Ala Glu Lys Gly Cys Asp Gln

195 200 205gtc gta tgg ttg gat gcc atc gag cac aag tac atc gaa gaa atg ggt 672Val Val Trp Leu Asp Ala Ile Glu His Lys Tyr Ile Glu Glu Met Gly

210 215 220ggc atg aac ctt ggg ttc atc tac cgc aac ggc gac caa gtc aag cta 720Gly Met Asn Leu Gly Phe Ile Tyr Arg Asn Gly Asp Gln Val Lys Leu225 230 235 240gtc acc cct gaa ctt tcc ggc tca cta ctt cca ggc atc acc cgc aag 768Val Thr Pro Glu Leu Ser Gly Ser Leu Leu Pro Gly Ile Thr Arg Lys

245250 255tca ctt cta caa gta gca cgc gac ttg gga tac gaa gta gaa gag cga 816Ser Leu Leu Gln Val Ala Arg Asp Leu Gly Tyr Glu Val Glu Glu Arg

260 265 270aag atc acc acc acc gag tgg gaa gaa gac gca aag tct ggc gcc atg 864Lys Ile Thr Thr Thr Glu Trp Glu Glu Asp Ala Lys Ser Gly Ala Met

275 280 285acc gag gca ttt gct tgc ggt act gca gct gtt atc acc cct gtt ggc 912Thr Glu Ala Phe Ala Cys Gly Thr Ala Ala Val Ile Thr Pro Val Gly

290 295 300acc gtg aaa tca gct cac ggc acc ttc gaa gtg aac aac aat gaa gtc 960Thr Val Lys Ser Ala His Gly Thr Phe Glu Val Asn Asn Asn Glu Val305 310 315 320gga gaa atc acg atg aag ctt cgt gaa acc ctc acc gga att cag caa 1008Gly Glu Ile Thr Met Lys Leu Arg Glu Thr Leu Thr Gly Ile Gln Gln

325 330 335gga aac gtt gaa gac caa aac gga tgg ctt tac cca ctg gtt ggc 1053Gly Asn Val Glu Asp Gln Asn Gly Trp Leu Tyr Pro Leu Val Gly

340345350 taaatcaacc ggttttaaga ccc 1076<6>264<211>351<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>264Pro Asp Arg Leu Lys Glu Ile Leu Ala Ala Pro Lys Phe Gly Lys Phe 151015 Phe Thr Asp His Met Val Thr Ile Asp Trp Asn Glu Ser Glu Gly Trp

20 25 30His Asn Ala Gln Leu Val Pro Tyr Ala Pro Ile Pro Met Asp Pro Ala

35 40 45Thr Thr Val Phe His Tyr Gly Gln Ala Ile Phe Glu Gly Ile Lys Ala

50 55 60Tyr Arg His Ser Asp Glu Thr Ile Lys Thr Phe Arg Pro Asp Glu Asn 65 7075 80Ala Glu Arg Met Gln Arg Ser Ala Ala Arg Met Ala Met Pro Gln Leu

85 90 95Pro Thr Glu Asp Phe Ile Lys Ala Leu Glu Leu Leu Val Asp Ala Asp

100 105 110Gln Asp Trp Val Pro Glu Tyr Gly Gly Glu Ala Ser Leu Tyr Leu Arg

115 120 125Pro Phe Met Ile Ser Thr Glu Ile Gly Leu Gly Val Ser Pro Ala Asp

130 135 140Ala Tyr Lys Phe Leu Val Ile Ala Ser Pro Val Gly Ala Tyr Phe Thr145 150 155 160Gly Gly Ile Lys Pro Val Ser Val Trp Leu Ser Glu Asp Tyr Val Arg

165 170 175Ala Ala Pro Gly Gly Thr Gly Asp Ala Lys Phe Ala Gly Asn Tyr Ala

180 185 190Ala Ser Leu Leu Ala Gln Ser Gln Ala Ala Glu Lys Gly Cys Asp Gln

195 200 205Val Val Trp Leu Asp Ala Ile Glu His Lys Tyr Ile Glu Glu Met Gly

210 215 220Gly Met Asn Leu Gly Phe Ile Tyr Arg Asn Gly Asp Gln Val Lys Leu225 230 235 240Val Thr Pro Glu Leu Ser Gly Ser Leu Leu Pro Gly Ile Thr Arg Lys

245 250 255Ser Leu Leu Gln Val Ala Arg Asp Leu Gly Tyr Glu Val Glu Glu Arg

260 265 270Lys Ile Thr Thr Thr Glu Trp Glu Glu Asp Ala Lys Ser Gly Ala Met

275 280 285Thr Glu Ala Phe Ala Cys Gly Thr Ala Ala Val Ile Thr Pro Val Gly

290 295 300Thr Val Lys Ser Ala His Gly Thr Phe Glu Val Asn Asn Asn Glu Val305 310 315 320Gly Glu Ile Thr Met Lys Leu Arg Glu Thr Leu Thr Gly Ile Gln Gln

325 330 335Gly Asn Val Glu Asp Gln Asn Gly Trp Leu Tyr Pro Leu Val Gly

340345350<210>265<211>1782<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1759)<223>RXN01026<400>265gaggtgacat ttatgcctct taatagctat actgtcccat gaaacgatat tttaatctca 60tatagtgaga tttacagatt tttaaaggac ggtgagttcc atg acc agc ccc gtg 115

Met Thr Ser Pro Val

1 5gag aac agc acc tca act gag aag ctg acc ctg gca gag aag gtg tgg 163Glu Asn Ser Thr Ser Thr Glu Lys Leu Thr Leu Ala Glu Lys Val Trp

10 15 20cgc gac cat gtc gtg tcc aag gga gaa aac ggc gag ccc gac ctc ctc 211Arg Asp His Val Val Ser Lys Gly Glu Asn Gly Glu Pro Asp Leu Leu

25 30 35tac atc gac ctg cag ctg ctg cat gaa gtg acc tca cca cag gca ttt 259Tyr Ile Asp Leu Gln Leu Leu His Glu Val Thr Ser Pro Gln Ala Phe

40 45 50gac ggc ctg cgc atg acc ggc cgt aaa ctg cgc cac cca gaa ctg cac 307Asp Gly Leu Arg Met Thr Gly Arg Lys Leu Arg His Pro Glu Leu His

55 60 65ctg gcc acc gaa gac cac aac gtg cca acc gaa ggc atc aag act ggc 355Leu Ala Thr Glu Asp His Asn Val Pro Thr Glu Gly Ile Lys Thr Gly 70 75 80 85tca ctg ctg gaa atc aac gac aag att tcc cgc ctg cag gta tct act 403Ser Leu Leu Glu Ile Asn Asp Lys Ile Ser Arg Leu Gln Val Ser Thr

90 95 100ctg cgc gac aac tgt gaa gaa ttc ggc gtg cgc ctg cac cca atg ggt 451Leu Arg Asp Asn Cys Glu Glu Phe Gly Val Arg Leu His Pro Met Gly

105 110 115gat gtc cga cag ggc atc gtg cac acc gtc ggc cca cag ctc ggc gca 499Asp Val Arg Gln Gly Ile Val His Thr Val Gly Pro Gln Leu Gly Ala

120 125 130acc cag cca ggc atg acc att gtg tgc ggt gac tcc cac acc tcc acc 547Thr Gln Pro Gly Met Thr Ile Val Cys Gly Asp Ser His Thr Ser Thr

135 140 145cac ggt gct ttt ggc tcc atg gca ttc ggc atc ggt acc tca gag gtt 595His Gly Ala Phe Gly Ser Met Ala Phe Gly Ile Gly Thr Ser Glu Val150 155 160 165gag cac gtc atg gct act caa acc ctg cca ctg aag cct ttc aag acc 643Glu His Val Met Ala Thr Gln Thr Leu Pro Leu Lys Pro Phe Lys Thr

170 175 180atg gcc att gaa gtt act ggt gaa ctg cag cca ggt gtt tcc tcc aag 691Met Ala Ile Glu Val Thr Gly Glu Leu Gln Pro Gly Val Ser Ser Lys

185 190 195gac ctg att ctg gcg att atc gcc aag atc ggc acc ggc ggc gga cag 739Asp Leu Ile Leu Ala Ile Ile Ala Lys Ile Gly Thr Gly Gly Gly Gln

200 205 210ggc tac gtt ctg gaa tac cgc ggc gaa gca atc cgt aag atg tcc atg 787Gly Tyr Val Leu Glu Tyr Arg Gly Glu Ala Ile Arg Lys Met Ser Met

215 220 225gat gca cgc atg acc atg tgc aac atg tcc atc gaa gct ggc gca cgt 835Asp Ala Arg Met Thr Met Cys Asn Met Ser Ile Glu Ala Gly Ala Arg230 235 240 245gcc ggc atg atc gcc cca gac caa acc acc ttc gac tac gtt gaa ggc 883Ala Gly Met Ile Ala Pro Asp Gln Thr Thr Phe Asp Tyr Val Glu Gly

250 255 260cgc gaa atg gca cca aag ggc gcc gac tgg gac gaa gca gtt gct tac 931Arg Glu Met Ala Pro Lys Gly Ala Asp Trp Asp Glu Ala Val Ala Tyr

265 270 275tgg aag acc ctg cca acc gac gaa ggc gca acc ttt gac aag gtc gta 979Trp Lys Thr Leu Pro Thr Asp Glu Gly Ala Thr Phe Asp Lys Val Val

280 285 290gaa atc gat ggc tcg gca ctg acc cca ttc atc acc tgg ggc acc aac 1027Glu Ile Asp Gly Ser Ala Leu Thr Pro Phe Ile Thr Trp Gly Thr Asn

295 300 305cca ggc cag ggc ctg cca ctg ggc gaa tcc gta cca agc cca gaa gac 1075Pro Gly Gln Gly Leu Pro Leu Gly Glu Ser Val Pro Ser Pro Glu Asp310 315 320 325ttc acc aac gac aac gac aag gca gca gcc gaa aag gca ctg cag tac 1123Phe Thr Asn Asp Asn Asp Lys Ala Ala Ala Glu Lys Ala Leu Gln Tyr

330 335 340atg gac ctg gta cca gga acc cca ctg cgc gac atc aag atc gac acc 1171Met Asp Leu Val Pro Gly Thr Pro Leu Arg Asp Ile Lys Ile Asp Thr

345 350 355gtc ttc ctg gga tcc tgc acc aac gcc cgc atc gaa gac ctg cag atc 1219Val Phe Leu Gly Ser Cys Thr Asn Ala Arg Ile Glu Asp Leu Gln Ile

360 365 370gcc gct gac atc ctc aag ggc cac aaa atc gcc gac ggc atg cgc atg 1267Ala Ala Asp Ile Leu Lys Gly His Lys Ile Ala Asp Gly Met Arg Met

375380 385atg gtc gtg cct tcc tcc acc tgg atc aag caa gag gca gaa gcg ctc 1315Met Val Val Pro Ser Ser Thr Trp Ile Lys Gln Glu Ala Glu Ala Leu390 395 400 405gga ctg gac aaa atc ttc acc gac gct ggc gct gaa tgg cgt acc gca 1363Gly Leu Asp Lys Ile Phe Thr Asp Ala Gly Ala Glu Trp Arg Thr Ala

410 415 420ggc tgc tcc atg tgc ctg ggc atg aac cca gac caa ctg aag cca ggc 1411Gly Cys Ser Met Cys Leu Gly Met Asn Pro Asp Gln Leu Lys Pro Gly

425 430 435gag cgc tcc gca ttc acc tcc aac cga aac ttc gaa gga cgc caa gga 1459Glu Arg Ser Ala Phe Thr Ser Asn Arg Asn Phe Glu Gly Arg Gln Gly

440 445 450cca gga ggc cgc acc cac ctg gta tcc cca gca gtc gca gcc gcc acc 1507Pro Gly Gly Arg Thr His Leu Val Ser Pro Ala Val Ala Ala Ala Thr

455 460 465gaa tcc gcg gac cct gtc ctc acc tgc aga tat cta agg aag gct aga 1555Glu Ser Ala Asp Pro Val Leu Thr Cys Arg Tyr Leu Arg Lys Ala Arg470 475 480 485aaa caa tgg aaa aat tta cca cct aca ccg gcg ttg gcg ttc cac tgc 1603Lys Gln Trp Lys Asn Leu Pro Pro Thr Pro Ala Leu Ala Phe His Cys

490 495 500agc gat cca acg tgg aca ccg acc aga tca tcc cag ccg tct acc tca 1651Ser Asp Pro Thr Trp Thr Pro Thr Arg Ser Ser Gln Pro Ser Thr Ser

505 510 515agc gcg tca ccc gga ccg gct tcg aag acg gac tgt ttt cca act ggc 1699Ser Ala Ser Pro Gly Pro Ala Ser Lys Thr Asp Cys Phe Pro Thr Gly

520 525 530gcc aaa acg acc cca act ttg tcc tca aca ccg aca cct aca aga acg 1747Ala Lys Thr Thr Pro Thr Leu Ser Ser Thr Pro Thr Pro Thr Arg Thr

535540545 gct ccg ttc tcg tagcaggccc tgactttggc acc 1782Ala Pro Phe Ser550<210>266<211>553<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>266Met Thr Ser Pro Val Glu Asn Ser Thr Ser Thr Glu Lys Leu Thr Leu 151015 Ala Glu Lys Val Trp Arg Asp His Val Val Ser Lys Gly Glu Asn Gly

20 25 30Glu Pro Asp Leu Leu Tyr Ile Asp Leu Gln Leu Leu His Glu Val Thr

35 40 45Ser Pro Gln Ala Phe Asp Gly Leu Arg Met Thr Gly Arg Lys Leu Arg

50 55 60His Pro Glu Leu His Leu Ala Thr Glu Asp His Asn Val Pro Thr Glu 65 70 75 80Gly Ile Lys Thr Gly Ser Leu Leu Glu Ile Asn Asp Lys Ile Ser Arg

85 90 95Leu Gln Val Ser Thr Leu Arg Asp Asn Cys Glu Glu Phe Gly Val Arg

100 105 110Leu His Pro Met Gly Asp Val Arg Gln Gly Ile Val His Thr Val Gly

115 120 125Pro Gln Leu Gly Ala Thr Gln Pro Gly Met Thr Ile Val Cys Gly Asp

130 135 140Ser His Thr Ser Thr His Gly Ala Phe Gly Ser Met Ala Phe Gly Ile145 150 155 160Gly Thr Ser Glu Val Glu His Val Met Ala Thr Gln Thr Leu Pro Leu

165 170 175Lys Pro Phe Lys Thr Met Ala Ile Glu Val Thr Gly Glu Leu Gln Pro

180 185 190Gly Val Ser Ser Lys Asp Leu Ile Leu Ala Ile Ile Ala Lys Ile Gly

195 200 205Thr Gly Gly Gly Gln Gly Tyr Val Leu Glu Tyr Arg Gly Glu Ala Ile

210 215 220Arg Lys Met Ser Met Asp Ala Arg Met Thr Met Cys Asn Met Ser Ile225 230 235 240Glu Ala Gly Ala Arg Ala Gly Met Ile Ala Pro Asp Gln Thr Thr Phe

245 250 255Asp Tyr Val Glu Gly Arg Glu Met Ala Pro Lys Gly Ala Asp Trp Asp

260 265 270Glu Ala Val Ala Tyr Trp Lys Thr Leu Pro Thr Asp Glu Gly Ala Thr

275 280 285Phe Asp Lys Val Val Glu Ile Asp Gly Ser Ala Leu Thr Pro Phe Ile

290 295 300Thr Trp Gly Thr Asn Pro Gly Gln Gly Leu Pro Leu Gly Glu Ser Val305 310 315 320Pro Ser Pro Glu Asp Phe Thr Asn Asp Asn Asp Lys Ala Ala Ala Glu

325 330 335Lys Ala Leu Gln Tyr Met Asp Leu Val Pro Gly Thr Pro Leu Arg Asp

340 345 350Ile Lys Ile Asp Thr Val Phe Leu Gly Ser Cys Thr Asn Ala Arg Ile

355 360 365Glu Asp Leu Gln Ile Ala Ala Asp Ile Leu Lys Gly His Lys Ile Ala

370 375 380Asp Gly Met Arg Met Met Val Val Pro Ser Ser Thr Trp Ile Lys Gln385 390 395 400Glu Ala Glu Ala Leu Gly Leu Asp Lys Ile Phe Thr Asp Ala Gly Ala

405 410 415Glu Trp Arg Thr Ala Gly Cys Ser Met Cys Leu Gly Met Asn Pro Asp

420 425 430Gln Leu Lys Pro Gly Glu Arg Ser Ala Phe Thr Ser Asn Arg Asn Phe

435 440 445Glu Gly Arg Gln Gly Pro Gly Gly Arg Thr His Leu Val Ser Pro Ala

450 455 460Val Ala Ala Ala Thr Glu Ser Ala Asp Pro Val Leu Thr Cys Arg Tyr465 470 475 480Leu Arg Lys Ala Arg Lys Gln Trp Lys Asn Leu Pro Pro Thr Pro Ala

485 490 495Leu Ala Phe His Cys Ser Asp Pro Thr Trp Thr Pro Thr Arg Ser Ser

500 505 510Gln Pro Ser Thr Ser Ser Ala Ser Pro Gly Pro Ala Ser Lys Thr Asp

515 520 525Cys Phe Pro Thr Gly Ala Lys Thr Thr Pro Thr Leu Ser Ser Thr Pro

530535540 Thr Pro Thr Arg Thr Ala Pro Phe Ser 545550<210>267<211>1625<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (1602)<223>FRXA01026<400>267gtg tgg cgc gac cat gtc gtg tcc aag gga gaa aac ggc gag ccc gac 48Val Trp Arg Asp His Val Val Ser Lys Gly Glu Asn Gly Glu Pro Asp 151015 ctc ctc tac atc gac ctg cag ctg ctg cat gaa gtg acc tca cca cag 96Leu Leu Tyr Ile Asp Leu Gln Leu Leu His Glu Val Thr Ser Pro Gln<25>CDS<222>(1).)

20 25 30gca ttt gac ggc ctg cgc atg acc ggc cgt aaa ctg cgc cac cca gaa 144Ala Phe Asp Gly Leu Arg Met Thr Gly Arg Lys Leu Arg His Pro Glu

35 40 45ctg cac ctg gcc acc gaa gac cac aac gtg cca acc gaa ggc atc aag 192Leu His Leu Ala Thr Glu Asp His Asn Val Pro Thr Glu Gly Ile Lys

50 55 60act ggc tca ctg ctg gaa atc aac gac aag att tcc cgc ctg cag gta 240Thr Gly Ser Leu Leu Glu Ile Asn Asp Lys Ile Ser Arg Leu Gln Val 65 70 75 80tct act ctg cgc gac aac tgt gaa gaa ttc ggc gtg cgc ctg cac cca 288Ser Thr Leu Arg Asp Asn Cys Glu Glu Phe Gly Val Arg Leu His Pro

85 90 95atg ggt gat gtc cga cag ggc atc gtg cac acc gtc ggc cca cag ctc 336Met Gly Asp Val Arg Gln Gly Ile Val His Thr Val Gly Pro Gln Leu

100 105 110ggc gca acc cag cca ggc atg acc att gtg tgc ggt gac tcc cac acc 384Gly Ala Thr Gln Pro Gly Met Thr Ile Val Cys Gly Asp Ser His Thr

115 120 125tcc acc cac ggt gct ttt ggc tcc atg gca ttc ggc atc ggt acc tca 432Ser Thr His Gly Ala Phe Gly Ser Met Ala Phe Gly Ile Gly Thr Ser

130 135 140gag gtt gag cac gtc atg gct act caa acc ctg cca ctg aag cct ttc 480Glu Val Glu His Val Met Ala Thr Gln Thr Leu Pro Leu Lys Pro Phe145 150 155 160aag acc atg gcc att gaa gtt act ggt gaa ctg cag cca ggt gtt tcc 528Lys Thr Met Ala Ile Glu Val Thr Gly Glu Leu Gln Pro Gly Val Ser

165 170 175tcc aag gac ctg att ctg gcg att atc gcc aag atc ggc acc ggc ggc 576Ser Lys Asp Leu Ile Leu Ala Ile Ile Ala Lys Ile Gly Thr Gly Gly

180 185 190gga cag ggc tac gtt ctg gaa tac cgc ggc gaa gca atc cgt aag atg 624Gly Gln Gly Tyr Val Leu Glu Tyr Arg Gly Glu Ala Ile Arg Lys Met

195 200 205tcc atg gat gcacgc atg acc atg tgc aac atg tcc atc gaa gct ggc 672Ser Met Asp Ala Arg Met Thr Met Cys Asn Met Ser Ile Glu Ala Gly

210 215 220gca cgt gcc ggc atg atc gcc cca gac caa acc acc ttc gac tac gtt 720Ala Arg Ala Gly Met Ile Ala Pro Asp Gln Thr Thr Phe Asp Tyr Val225 230 235 240gaa ggc cgc gaa atg gca cca aag ggc gcc gac tgg gac gaa gca gtt 768Glu Gly Arg Glu Met Ala Pro Lys Gly Ala Asp Trp Asp Glu Ala Val

245 250 255gct tac tgg aag acc ctg cca acc gac gaa ggc gca acc ttt gac aag 816Ala Tyr Trp Lys Thr Leu Pro Thr Asp Glu Gly Ala Thr Phe Asp Lys

260 265 270gtc gta gaa atc gat ggc tcg gca ctg acc cca ttc atc acc tgg ggc 864Val Val Glu Ile Asp Gly Ser Ala Leu Thr Pro Phe Ile Thr Trp Gly

275 280 285acc aac cca ggc cag ggc ctg cca ctg ggc gaa tcc gta cca agc cca 912Thr Asn Pro Gly Gln Gly Leu Pro Leu Gly Glu Ser Val Pro Ser Pro

290 295 300gaa gac ttc acc aac gac aac gac aag gca gca gcc gaa aag gca ctg 960Glu Asp Phe Thr Asn Asp Asn Asp Lys Ala Ala Ala Glu Lys Ala Leu305 310 315 320cag tac atg gac ctg gta cca gga acc cca ctg cgc gac atc aag atc 1008Gln Tyr Met Asp Leu Val Pro Gly Thr Pro Leu Arg Asp Ile Lys Ile

325 330 335gac acc gtc ttc ctg gga tcc tgc acc aac gcc cgc atc gaa gac ctg 1056Asp Thr Val Phe Leu Gly Ser Cys Thr Asn Ala Arg Ile Glu Asp Leu

340 345 350cag atc gcc gct gac atc ctc aag ggc cac aaa atc gcc gac ggc atg 1104Gln Ile Ala Ala Asp Ile Leu Lys Gly His Lys IleAla Asp Gly Met

355 360 365cgc atg atg gtc gtg cct tcc tcc acc tgg atc aag caa gag gca gaa 1152Arg Met Met Val Val Pro Ser Ser Thr Trp Ile Lys Gln Glu Ala Glu

370 375 380gcg ctc gga ctg gac aaa atc ttc acc gac gct ggc gct gaa tgg cgt 1200Ala Leu Gly Leu Asp Lys Ile Phe Thr Asp Ala Gly Ala Glu Trp Arg385 390 395 400acc gca ggc tgc tcc atg tgc ctg ggc atg aac cca gac caa ctg aag 1248Thr Ala Gly Cys Ser Met Cys Leu Gly Met Asn Pro Asp Gln Leu Lys

405 410 415cca ggc gag cgc tcc gca ttc acc tcc aac cga aac ttc gaa gga cgc 1296Pro Gly Glu Arg Ser Ala Phe Thr Ser Asn Arg Asn Phe Glu Gly Arg

420 425 430caa gga cca gga ggc cgc acc cac ctg gta tcc cca gca gtc gca gcc 1344Gln Gly Pro Gly Gly Arg Thr His Leu Val Ser Pro Ala Val Ala Ala

435 440 445gcc acc gaa tcc gcg gac cct gtc ctc acc tgc aga tat cta agg aag 1392Ala Thr Glu Ser Ala Asp Pro Val Leu Thr Cys Arg Tyr Leu Arg Lys

450 455 460gct aga aaa caa tgg aaa aat tta cca cct aca ccg gcg ttg gcg ttc 1440Ala Arg Lys Gln Trp Lys Asn Leu Pro Pro Thr Pro Ala Leu Ala Phe465 470 475 480cac tgc agc gat cca acg tgg aca ccg acc aga tca tcc cag ccg tct 1488His Cys Ser Asp Pro Thr Trp Thr Pro Thr Arg Ser Ser Gln Pro Ser

485 490 495acc tca agc gcg tca ccc gga ccg gct tcg aag acg gac tgt ttt cca 1536Thr Ser Ser Ala Ser Pro Gly Pro Ala Ser Lys Thr Asp Cys Phe Pro

500 505 510act ggc gcc aaa acg acc cca act ttg tcc tca aca ccg aca cct aca 1584Thr Gly Ala Lys Thr Thr Pro Thr Leu Ser Ser Thr Pro Thr Pro Thr

515 520 525aga acg gct ccg ttc tcg tagcaggccc tgactttggc acc 1625Arg Thr Ala Pro Phe Ser

530<210>268<211>534<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>268Val Trp Arg Asp His Val Val Ser Lys Gly Glu Asn Gly Glu Pro Asp 151015 Leu Leu Tyr Ile Asp Leu Gln Leu Leu His Glu Val Thr Ser Pro Gln

20 25 30Ala Phe Asp Gly Leu Arg Met Thr Gly Arg Lys Leu Arg His Pro Glu

35 40 45Leu His Leu Ala Thr Glu Asp His Asn Val Pro Thr Glu Gly Ile Lys

50 55 60Thr Gly Ser Leu Leu Glu Ile Asn Asp Lys Ile Ser Arg Leu Gln Val 65 70 75 80Ser Thr Leu Arg Asp Asn Cys Glu Glu Phe Gly Val Arg Leu His Pro

85 90 95Met Gly Asp Val Arg Gln Gly Ile Val His Thr Val Gly Pro Gln Leu

100 105 110Gly Ala Thr Gln Pro Gly Met Thr Ile Val Cys Gly Asp Ser His Thr

115 120 125Ser Thr His Gly Ala Phe Gly Ser Met Ala Phe Gly Ile Gly Thr Ser

130 135 140Glu Val Glu His Val Met Ala Thr Gln Thr Leu Pro Leu Lys Pro Phe145 150 155 160Lys Thr Met Ala Ile Glu Val Thr Gly Glu Leu Gln Pro Gly Val Ser

165 170 175Ser Lys Asp Leu Ile Leu Ala Ile Ile Ala Lys Ile Gly Thr Gly Gly

180 185 190Gly Gln Gly Tyr Val Leu Glu Tyr Arg Gly Glu Ala Ile Arg Lys Met

195 200 205Ser Met Asp Ala Arg Met Thr Met Cys Asn Met Ser Ile Glu Ala Gly

210 215 220Ala Arg Ala Gly Met Ile Ala Pro Asp Gln Thr Thr Phe Asp Tyr Val225 230 235 240Glu Gly Arg Glu Met Ala Pro Lys Gly Ala Asp Trp Asp Glu Ala Val

245 250 255Ala Tyr Trp Lys Thr Leu Pro Thr Asp Glu Gly Ala Thr Phe Asp Lys

260 265 270Val Val Glu Ile Asp Gly Ser Ala Leu Thr Pro Phe Ile Thr Trp Gly

275 280 285Thr Asn Pro Gly Gln Gly Leu Pro Leu Gly Glu Ser Val Pro Ser Pro

290 295 300Glu Asp Phe Thr Asn Asp Asn Asp Lys Ala Ala Ala Glu Lys Ala Leu305 310 315 320Gln Tyr Met Asp Leu Val Pro Gly Thr Pro Leu Arg Asp Ile Lys Ile

325 330 335Asp Thr Val Phe Leu Gly Ser Cys Thr Asn Ala Arg Ile Glu Asp Leu

340 345 350Gln Ile Ala Ala Asp Ile Leu Lys Gly His Lys Ile Ala Asp Gly Met

355 360 365Arg Met Met Val Val Pro Ser Ser Thr Trp Ile Lys Gln Glu Ala Glu

370 375 380Ala Leu Gly Leu Asp Lys Ile Phe Thr Asp Ala Gly Ala Glu Trp Arg385 390 395 400Thr Ala Gly Cys Ser Met Cys Leu Gly Met Asn Pro Asp Gln Leu Lys

405 410 415Pro Gly Glu Arg Ser Ala Phe Thr Ser Asn Arg Asn Phe Glu Gly Arg

420 425 430Gln Gly Pro Gly Gly Arg Thr His Leu Val Ser Pro Ala Val Ala Ala

435 440 445Ala Thr Glu Ser Ala Asp Pro Val Leu Thr Cys Arg Tyr Leu Arg Lys

450 455 460Ala Arg Lys Gln Trp Lys Asn Leu Pro Pro Thr Pro Ala Leu Ala Phe465 470 475 480His Cys Ser Asp Pro Thr Trp Thr Pro Thr Arg Ser Ser Gln Pro Ser

485 490 495Thr Ser Ser Ala Ser Pro Gly Pro Ala Ser Lys Thr Asp Cys Phe Pro

500 505 510Thr Gly Ala Lys Thr Thr Pro Thr Leu Ser Ser Thr Pro Thr Pro Thr

515 520 525Arg Thr Ala Pro Phe Ser

530<210>269<211>1143<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). - (1120)<223>RXN01127<400>269gccctgcatg atggggtagt gggggttgtt gggcaggtac gagctgtgat caatcagcta 60cactagtgaa gtccatatag tgagaaggga atcccacaac atg aaa ctt gct gtt 115

Met Lys Leu Ala Val

1 5att ggt gga gat ggt atc ggc cca gag gtt act gca gaa gcc ctc aag 163Ile Gly Gly Asp Gly Ile Gly Pro Glu Val Thr Ala Glu Ala Leu Lys

10 15 20gtt cta aac gct gtc cgc gac gac atc gag acc acc gat tat gac ctt 211Val Leu Asn Ala Val Arg Asp Asp Ile Glu Thr Thr Asp Tyr Asp Leu

25 30 35ggc gca cgc cgt tac ctc aaa aat ggc gag ctg ctc acc gac gag gat 259Gly Ala Arg Arg Tyr Leu Lys Asn Gly Glu Leu Leu Thr Asp Glu Asp

40 45 50ctg gca tcc ctg cgc gag cat gac gcg atc ctt ctt ggc gct atc ggt 307Leu Ala Ser Leu Arg Glu His Asp Ala Ile Leu Leu Gly Ala Ile Gly

55 60 65gca cca ggt tcc gtc cct cca gga att ctc gag cgt ggt ttg ctg ctg 355Ala Pro Gly Ser Val Pro Pro Gly Ile Leu Glu Arg Gly Leu Leu Leu 70 75 80 85aag atg cga ttc gca ctg gat cac cac gtg aac ctg cgc cca tcc aag 403Lys Met Arg Phe Ala Leu Asp His His Val Asn Leu Arg Pro Ser Lys

90 95 100ctg tac gac ggc gtg gag tcc cca ctg cgt aac cca ggc aag att gat 451Leu Tyr Asp Gly Val Glu Ser Pro Leu Arg Asn Pro Gly Lys Ile Asp

105 110 115ttc gtt gtg gtc cgc gaa ggt acc gaa ggc gcc tac act ggc aac ggt 499Phe Val Val Val Arg Glu Gly Thr Glu Gly Ala Tyr Thr Gly Asn Gly

120 125 130gga gca atc cgc gtg gga acc cct cac gag att gcc aat gaa acc tcc 547Gly Ala Ile Arg Val Gly Thr Pro His Glu Ile Ala Asn Glu Thr Ser

135 140 145gtg aac act cgc tac ggc gct gag cgc gtt att cgc tac gca ttc gag 595Val Asn Thr Arg Tyr Gly Ala Glu Arg Val Ile Arg Tyr Ala Phe Glu150 155 160 165ctg gca cag agc cgc cgc aag aag ctc acc ctc gtg cac aag acc aac 643Leu Ala Gln Ser Arg Arg Lys Lys Leu Thr Leu Val His Lys Thr Asn

170 175 180gtc ctg gtt cac ggt ggt ggc ctg tgg cag cgc acc gta gat gag gtt 691Val Leu Val His Gly Gly Gly Leu Trp Gln Arg Thr Val Asp Glu Val

185 190 195gca aag gaa tac cca gag gta gcc gtc gat tac aac cac atc gat gca 739Ala Lys Glu Tyr Pro Glu Val Ala Val Asp Tyr Asn His Ile Asp Ala

200 205 210gca acc atc tat ctg gtc act gat cct tcc cgc ttc gat gtg att gtt 787Ala Thr Ile Tyr Leu Val Thr Asp Pro Ser Arg Phe Asp Val Ile Val

215 220 225acc gat aac ctc ttc ggc gac atc ctc acc gat gag gca ggc gca gtc 835Thr Asp Asn Leu Phe Gly Asp Ile Leu Thr Asp Glu Ala Gly Ala Val230 235 240 245tct ggc gga att ggc ctc gca gca tcc ggc aac atc gat gcc acg ggc 883Ser Gly Gly Ile Gly Leu Ala Ala Ser Gly Asn Ile Asp Ala Thr Gly

250 255 260acc aac cct tcc atg ttc gag cca gtc cac ggc tct gca cca gat atc 931Thr Asn Pro Ser Met Phe Glu Pro Val His Gly Ser Ala Pro Asp Ile

265 270 275gca ggc cag gga atc gca gac cca acg gca gca atc cta tcc gct gcg 979Ala Gly Gln Gly Ile Ala Asp Pro Thr Ala Ala Ile Leu Ser Ala Ala

280 285 290atg ctg ctg cgt cac tta ggt gat gaa gac aac gca gta cgt att gaa 1027Met Leu Leu Arg His Leu Gly Asp Glu Asp Asn Ala Val Arg Ile Glu

295 300 305aca gcc atc gca gct gat gtg gct ggc cga gat aac tct cag ccg att 1075Thr Ala Ile Ala Ala Asp Val Ala Gly Arg Asp Asn Ser Gln Pro Ile310 315 320 325tct acc act gag gtg gga gac cgc atc gtc aag gcg ctg caa agc 1120Ser Thr Thr Glu Val Gly Asp Arg Ile Val Lys Ala Leu Gln Ser

330335340 taaatttcaa cgccgacccc ctt 1143<210>270<211>340<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>270Met Lys Leu Ala Val Ile Gly Gly Asp Gly Ile Gly Pro Glu Val Thr 151015 Ala Glu Ala Leu Lys Val Leu Asn Ala Val Arg Asp Asp Ile Glu Thr

20 25 30Thr Asp Tyr Asp Leu Gly Ala Arg Arg Tyr Leu Lys Asn Gly Glu Leu

35 40 45Leu Thr Asp Glu Asp Leu Ala Ser Leu Arg Glu His Asp Ala Ile Leu

50 55 60Leu Gly Ala Ile Gly Ala Pro Gly Ser Val Pro Pro Gly Ile Leu Glu 65 70 75 80Arg Gly Leu Leu Leu Lys Met Arg Phe Ala Leu Asp His His Val Asn

85 90 95Leu Arg Pro Ser Lys Leu Tyr Asp Gly Val Glu Ser Pro Leu Arg Asn

100 105 110Pro Gly Lys Ile Asp Phe Val Val Val Arg Glu Gly Thr Glu Gly Ala

115 120 125Tyr Thr Gly Asn Gly Gly Ala Ile Arg Val Gly Thr Pro His Glu Ile

130 135 140Ala Asn Glu Thr Ser Val Asn Thr Arg Tyr Gly Ala Glu Arg Val Ile145 150 155 160Arg Tyr Ala Phe Glu Leu Ala Gln Ser Arg Arg Lys Lys Leu Thr Leu

165 170 175Val His Lys Thr Asn Val Leu Val His Gly Gly Gly Leu Trp Gln Arg

180 185 190Thr Val Asp Glu Val Ala Lys Glu Tyr Pro Glu Val Ala Val Asp Tyr

195 200 205Asn His Ile Asp Ala Ala Thr Ile Tyr Leu Val Thr Asp Pro Ser Arg

210 215 220Phe Asp Val Ile Val Thr Asp Asn Leu Phe Gly Asp Ile Leu Thr Asp225 230 235 240Glu Ala Gly Ala Val Ser Gly Gly Ile Gly Leu Ala Ala Ser Gly Asn

245 250 255Ile Asp Ala Thr Gly Thr Asn Pro Ser Met Phe Glu Pro Val His Gly

260 265 270Ser Ala Pro Asp Ile Ala Gly Gln Gly Ile Ala Asp Pro Thr Ala Ala

275 280 285Ile Leu Ser Ala Ala Met Leu Leu Arg His Leu Gly Asp Glu Asp Asn

290 295 300Ala Val Arg Ile Glu Thr Ala Ile Ala Ala Asp Val Ala Gly Arg Asp305 310 315 320Asn Ser Gln Pro Ile Ser Thr Thr Glu Val Gly Asp Arg Ile Val Lys

325 330 335Ala Leu Gln Ser

340<210>271<211>403<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (403)<223>FRXA01132<400>271gccctgcatg atggggtagt gggggttgtt gggcaggtac gagctgtgat caatcagcta 60cactagtgaa gtccatatag tgagaaggga atcccacaac atg aaa ctt gct gtt 115

Met Lys Leu Ala Val

1 5att ggt gga gat ggt atc ggc cca gag gtt act gca gaa gcc ctc aag 163Ile Gly Gly Asp Gly Ile Gly Pro Glu Val Thr Ala Glu Ala Leu Lys

10 15 20gtt cta aac gct gtc cgc gac gac atc gag acc acc gat tat gac ctt 211Val Leu Asn Ala Val Arg Asp Asp Ile Glu Thr Thr Asp Tyr Asp Leu

25 30 35ggc gca cgc cgt tac ctc aaa aat ggc gag ctg ctc acc gac gag gat 259Gly Ala Arg Arg Tyr Leu Lys Asn Gly Glu Leu Leu Thr Asp Glu Asp

40 45 50ctg gca tcc ctg cgc gag cat gac gcg atc ctt ctt ggc gct atc ggt 307Leu Ala Ser Leu Arg Glu His Asp Ala Ile Leu Leu Gly Ala Ile Gly

55 60 65gca cca ggt tcc gtc cct cca gga att ctc gag cgt ggt ttg ctg ctg 355Ala Pro Gly Ser Val Pro Pro Gly Ile Leu Glu Arg Gly Leu Leu Leu 70 75 80 85aag atg cga ttc gca ctg gat cac cac gtg aac ctg cgc cca tcc aag 403Lys Met Arg Phe Ala Leu Asp His His Val Asn Leu Arg Pro Ser Lys

9095100<210>272<211>101<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>272Met Lys Leu Ala Val Ile Gly Gly Asp Gly Ile Gly Pro Glu Val Thr 151015 Ala Glu Ala Leu Lys Val Leu Asn Ala Val Arg Asp Asp Ile Glu Thr

20 25 30Thr Asp Tyr Asp Leu Gly Ala Arg Arg Tyr Leu Lys Asn Gly Glu Leu

35 40 45Leu Thr Asp Glu Asp Leu Ala Ser Leu Arg Glu His Asp Ala Ile Leu

50 55 60Leu Gly Ala Ile Gly Ala Pro Gly Ser Val Pro Pro Gly Ile Leu Glu 65 70 75 80Arg Gly Leu Leu Leu Lys Met Arg Phe Ala Leu Asp His His Val Asn

85 90 95Leu Arg Pro Ser Lys

100<210>273<211>1494<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1471)<223>RXN00536<400>273cggcgggtcc cagaggtctt aacacgaccg gcatcccgtc gcggagtttg gtgttgccgg 60tcgtggaccc acccaaaact ttttaagaag gttgaacaca atg tct cct aac gat 115

Met Ser Pro Asn Asp

1 5gca ttc atc tcc gca cct gcc aag atc gaa acc cca gtt ggg cct cgc 163Ala Phe Ile Ser Ala Pro Ala Lys Ile Glu Thr Pro Val Gly Pro Arg

10 15 20aac gaa ggc cag cca gca tgg aat aag cag cgt ggc tcc tca atg cca 211Asn Glu Gly Gln Pro Ala Trp Asn Lys Gln Arg Gly Ser Ser Met Pro

25 30 35gtt aac cgc tac atg cct ttc gag gtt gag gta gaa gat att tct ctg 259Val Asn Arg Tyr Met Pro Phe Glu Val Glu Val Glu Asp Ile Ser Leu

40 45 50ccg gac cgc act tgg cca gat aaa aaa atc acc gtt gca cct cag tgg 307Pro Asp Arg Thr Trp Pro Asp Lys Lys Ile Thr Val Ala Pro Gln Trp

55 60 65tgt gct gtt gac ctg cgt gac ggc aac cag gct ctg att gat ccg atg 355Cys Ala Val Asp Leu Arg Asp Gly Asn Gln Ala Leu Ile Asp Pro Met 70 75 80 85tct cct gag cgt aag cgc cgc atg ttt gag ctg ctg gtt cag atg ggc 403Ser Pro Glu Arg Lys Arg Arg Met Phe Glu Leu Leu Val Gln Met Gly

90 95 100ttc aaa gaa atc gag gtc ggt ttc cct tca gct tcc cag act gat ttt 451Phe Lys Glu Ile Glu Val Gly Phe Pro Ser Ala Ser Gln Thr Asp Phe

105 110 115gat ttc gtt cgt gag atc atc gaa aag ggc atg atc cct gac gat gtc 499Asp Phe Val Arg Glu Ile IleGlu Lys Gly Met Ile Pro Asp Asp Val

120 125 130acc att cag gtt ctg gtt cag gct cgt gag cac ctg att cgc cgt act 547Thr Ile Gln Val Leu Val Gln Ala Arg Glu His Leu Ile Arg Arg Thr

135 140 145ttt gaa gct tgc gaa ggc gca aaa aac gtt atc gtg cac ttc tac aac 595Phe Glu Ala Cys Glu Gly Ala Lys Asn Val Ile Val His Phe Tyr Asn150 155 160 165tcc acc tcc atc ctg cag cgc aac gtg gtg ttc cgc atg gac aag gtg 643Ser Thr Ser Ile Leu Gln Arg Asn Val Val Phe Arg Met Asp Lys Val

170 175 180cag gtg aag aag ctg gct acc gat gcc gct gaa cta atc aag acc atc 691Gln Val Lys Lys Leu Ala Thr Asp Ala Ala Glu Leu Ile Lys Thr Ile

185 190 195gct cag gat tac cca gac acc aac tgg cgc tgg cag tac tcc cct gag 739Ala Gln Asp Tyr Pro Asp Thr Asn Trp Arg Trp Gln Tyr Ser Pro Glu

200 205 210tcc ttc acc ggc act gag gtt gag tac gcc aag gaa gtt gtg gac gca 787Ser Phe Thr Gly Thr Glu Val Glu Tyr Ala Lys Glu Val Val Asp Ala

215 220 225gtt gtt gag gtc atg gat cca act cct gag aac cca atg atc atc aac 835Val Val Glu Val Met Asp Pro Thr Pro Glu Asn Pro Met Ile Ile Asn230 235 240 245ctg cct tcc acc gtt gag atg atc acc cct aac gtt tac gca gac tcc 883Leu Pro Ser Thr Val Glu Met Ile Thr Pro Asn Val Tyr Ala Asp Ser

250 255 260att gaa tgg atg cac cgc aat cta aac cgt cgt gat tcc att atc ctg 931Ile Glu Trp Met His Arg Asn Leu Asn Arg Arg Asp Ser Ile Ile Leu

265 270275tcc ctg cac ccg cac aat gac cgt ggc acc ggc gtt ggc gca gct gag 979Ser Leu His Pro His Asn Asp Arg Gly Thr Gly Val Gly Ala Ala Glu

280 285 290ctg ggc tac atg gct ggc gct gac cgc atc gaa ggc tgc ctg ttc ggc 1027Leu Gly Tyr Met Ala Gly Ala Asp Arg Ile Glu Gly Cys Leu Phe Gly

295 300 305aac ggc gag cgc acc ggc aac gtc tgc ctg gtc acc ctg gca ctg aac 1075Asn Gly Glu Arg Thr Gly Asn Val Cys Leu Val Thr Leu Ala Leu Asn310 315 320 325atg ctg acc cag ggc gtt gac cct cag ctg gac ttc acc gat ata cgc 1123Met Leu Thr Gln Gly Val Asp Pro Gln Leu Asp Phe Thr Asp Ile Arg

330 335 340cag atc cgc agc acc gtt gaa tac tgc aac cag ctg cgc gtt cct gag 1171Gln Ile Arg Ser Thr Val Glu Tyr Cys Asn Gln Leu Arg Val Pro Glu

345 350 355cgc cac cca tac ggc ggt gac ctg gtc ttc acc gct ttc tcc ggt tcc 1219Arg His Pro Tyr Gly Gly Asp Leu Val Phe Thr Ala Phe Ser Gly Ser

360 365 370cac cag gac gct gtg aac aag ggt ctg gac gcc atg gct gcc aag gtt 1267His Gln Asp Ala Val Asn Lys Gly Leu Asp Ala Met Ala Ala Lys Val

375 380 385cag cca ggt gct agc tcc act gaa gtt tct tgg gag cag ctg cgc gac 1315Gln Pro Gly Ala Ser Ser Thr Glu Val Ser Trp Glu Gln Leu Arg Asp390 395 400 405acc cga atg gga ggt tcc tta cct gcc tat cga tcc aaa gga tgt cgg 1363Thr Arg Met Gly Gly Ser Leu Pro Ala Tyr Arg Ser Lys Gly Cys Arg

410 415 420tcg cga cta cga ggc tgt tat ccg cgt gaa ctc cca gtc cgg caa ggg 1411Ser Arg Leu Arg Gly Cys Tyr ProArg Glu Leu Pro Val Arg Gln Gly

425 430 435cgg cgt tgc tta cat cat gaa gac cga tca cgg tct gca gat ccc tcg 1459Arg Arg Cys Leu His His Glu Asp Arg Ser Arg Ser Ala Asp Pro Ser

440 445 450ctc cat gca ggt tgagttctcc accgttgtcc aga 1494Leu His Ala Gly

455<210>274<211>457<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>274Met Ser Pro Asn Asp Ala Phe Ile Ser Ala Pro Ala Lys Ile Glu Thr 151015 Pro Val Gly Pro Arg Asn Glu Gly Gln Pro Ala Trp Asn Lys Gln Arg

20 25 30Gly Ser Ser Met Pro Val Asn Arg Tyr Met Pro Phe Glu Val Glu Val

35 40 45Glu Asp Ile Ser Leu Pro Asp Arg Thr Trp Pro Asp Lys Lys Ile Thr

50 55 60Val Ala Pro Gln Trp Cys Ala Val Asp Leu Arg Asp Gly Asn Gln Ala 65 70 75 80Leu Ile Asp Pro Met Ser Pro Glu Arg Lys Arg Arg Met Phe Glu Leu

85 90 95Leu Val Gln Met Gly Phe Lys Glu Ile Glu Val Gly Phe Pro Ser Ala

100 105 110Ser Gln Thr Asp Phe Asp Phe Val Arg Glu Ile Ile Glu Lys Gly Met

115 120 125Ile Pro Asp Asp Val Thr Ile Gln Val Leu Val Gln Ala Arg Glu His

130 135 140Leu Ile Arg Arg Thr Phe Glu Ala Cys Glu Gly Ala Lys Asn Val Ile145 150 155 160Val His Phe Tyr Asn Ser Thr Ser Ile Leu Gln Arg Asn Val Val Phe

165 170 175Arg Met Asp Lys Val Gln Val Lys Lys Leu Ala Thr Asp Ala Ala Glu

180 185 190Leu Ile Lys Thr Ile Ala Gln Asp Tyr Pro Asp Thr Asn Trp Arg Trp

195 200 205Gln Tyr Ser Pro Glu Ser Phe Thr Gly Thr Glu Val Glu Tyr Ala Lys

210 215 220Glu Val Val Asp Ala Val Val Glu Val Met Asp Pro Thr Pro Glu Asn225 230 235 240Pro Met Ile Ile Asn Leu Pro Ser Thr Val Glu Met Ile Thr Pro Asn

245 250 255Val Tyr Ala Asp Ser Ile Glu Trp Met His Arg Asn Leu Asn Arg Arg

260 265 270Asp Ser Ile Ile Leu Ser Leu His Pro His Asn Asp Arg Gly Thr Gly

275 280 285Val Gly Ala Ala Glu Leu Gly Tyr Met Ala Gly Ala Asp Arg Ile Glu

290 295 300Gly Cys Leu Phe Gly Asn Gly Glu Arg Thr Gly Asn Val Cys Leu Val305 310 315 320Thr Leu Ala Leu Asn Met Leu Thr Gln Gly Val Asp Pro Gln Leu Asp

325 330 335Phe Thr Asp Ile Arg Gln Ile Arg Ser Thr Val Glu Tyr Cys Asn Gln

340 345 350Leu Arg Val Pro Glu Arg His Pro Tyr Gly Gly Asp Leu Val Phe Thr

355 360 365Ala Phe Ser Gly Ser His Gln Asp Ala Val Asn Lys Gly Leu Asp Ala

370 375 380Met Ala Ala Lys Val Gln Pro Gly Ala Ser Ser Thr Glu Val Ser Trp385390 395 400Glu Gln Leu Arg Asp Thr Arg Met Gly Gly Ser Leu Pro Ala Tyr Arg

405 410 415Ser Lys Gly Cys Arg Ser Arg Leu Arg Gly Cys Tyr Pro Arg Glu Leu

420 425 430Pro Val Arg Gln Gly Arg Arg Cys Leu His His Glu Asp Arg Ser Arg

435 440 445Ser Ala Asp Pro Ser Leu His Ala Gly

450455<210>275<211>1333<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1333)<223>FRXA00536<400>275cggcgggtcc cagaggtctt aacacgaccg gcatcccgtc gcggagtttg gtgttgccgg 60tcgtggaccc acccaaaact ttttaagaag gttgaacaca atg tct cct aac gat 115

Met Ser Pro Asn Asp

1 5gca ttc atc tcc gca cct gcc aag atc gaa acc cca gtt ggg cct cgc 163Ala Phe Ile Ser Ala Pro Ala Lys Ile Glu Thr Pro Val Gly Pro Arg

10 15 20aac gaa ggc cag cca gca tgg aat aag cag cgt ggc tcc tca atg cca 211Asn Glu Gly Gln Pro Ala Trp Asn Lys Gln Arg Gly Ser Ser Met Pro

25 30 35gtt aac cgc tac atg cct ttc gag gtt gag gta gaa gat att tct ctg 259Val Asn Arg Tyr Met Pro Phe Glu Val Glu Val Glu Asp Ile Ser Leu

40 45 50ccg gac cgc act tgg cca gat aaa aaa atc acc gtt gca cct cag tgg 307Pro Asp Arg Thr Trp Pro Asp Lys Lys Ile Thr Val Ala Pro Gln Trp

55 60 65tgt gct gtt gac ctg cgt gac ggc aac cag gct ctg att gat ccg atg 355Cys Ala Val Asp Leu Arg Asp Gly Asn Gln Ala Leu Ile Asp Pro Met 70 75 80 85tct cct gag cgt aag cgc cgc atg ttt gag ctg ctg gtt cag atg ggc 403Ser Pro Glu Arg Lys Arg Arg Met Phe Glu Leu Leu Val Gln Met Gly

90 95 100ttc aaa gaa atc gag gtc ggt ttc cct tca gct tcc cag act gat ttt 451Phe Lys Glu Ile Glu Val Gly Phe Pro Ser Ala Ser Gln Thr Asp Phe

105 110 115gat ttc gtt cgt gag atc atc gaa aag ggc atg atc cct gac gat gtc 499Asp Phe Val Arg Glu Ile Ile Glu Lys Gly Met Ile Pro Asp Asp Val

120 125 130acc att cag gtt ctg gtt cag gct cgt gag cac ctg att cgc cgt act 547Thr Ile Gln Val Leu Val Gln Ala Arg Glu His Leu Ile Arg Arg Thr

135 140 145ttt gaa gct tgc gaa ggc gca aaa aac gtt atc gtg cac ttc tac aac 595Phe Glu Ala Cys Glu Gly Ala Lys Asn Val Ile Val His Phe Tyr Asn150 155 160 165tcc acc tcc atc ctg cag cgc aac gtg gtg ttc cgc atg gac aag gtg 643Ser Thr Ser Ile Leu Gln Arg Asn Val Val Phe Arg Met Asp Lys Val

170 175 180cag gtg aag aag ctg gct acc gat gcc gct gaa cta atc aag acc atc 691Gln Val Lys Lys Leu Ala Thr Asp Ala Ala Glu Leu Ile Lys Thr Ile

185 190 195gct cag gat tac cca gac acc aac tgg cgc tgg cag tac tcc cct gag 739Ala Gln Asp Tyr Pro Asp Thr Asn Trp Arg Trp Gln Tyr Ser Pro Glu

200 205 210tcc ttc acc ggc act gag gtt gag tac gcc aag gaa gtt gtg gac gca 787Ser Phe Thr Gly Thr Glu Val Glu Tyr Ala Lys Glu Val Val Asp Ala

215 220 225gtt gtt gag gtc atg gat cca act cct gag aac cca atg atc atc aac 835Val Val Glu Val Met Asp Pro Thr Pro Glu Asn Pro Met Ile Ile Asn230 235 240 245ctg cct tcc acc gtt gag atg atc acc cct aac gtt tac gca gac tcc 883Leu Pro Ser Thr Val Glu Met Ile Thr Pro Asn Val Tyr Ala Asp Ser

250 255 260att gaa tgg atg cac cgc aat cta aac cgt cgt gat tcc att atc ctg 931Ile Glu Trp Met His Arg Asn Leu Asn Arg Arg Asp Ser Ile Ile Leu

265 270 275tcc ctg cac ccg cac aat gac cgt ggc acc ggc gtt ggc gca gct gag 979Ser Leu His Pro His Asn Asp Arg Gly Thr Gly Val Gly Ala Ala Glu

280 285 290ctg ggc tac atg gct ggc gct gac cgc atc gaa ggc tgc ctg ttc ggc 1027Leu Gly Tyr Met Ala Gly Ala Asp Arg Ile Glu Gly Cys Leu Phe Gly

295 300 305aac ggc gag cgc acc ggc aac gtc tgc ctg gtc acc ctg gca ctg aac 1075Asn Gly Glu Arg Thr Gly Asn Val Cys Leu Val Thr Leu Ala Leu Asn310 315 320 325atg ctg acc cag ggc gtt gac cct cag ctg gac ttc acc gat ata cgc 1123Met Leu Thr Gln Gly Val Asp Pro Gln Leu Asp Phe Thr Asp Ile Arg

330 335 340cag atc cgc agc acc gtt gaa tac tgc aac cag ctg cgc gtt cct gag 1171Gln Ile Arg Ser Thr Val Glu Tyr Cys Asn Gln Leu Arg Val Pro Glu

345 350 355cgc cac cca tac ggc ggt gac ctg gtc ttc acc gct ttc tcc ggt tcc 1219Arg His Pro Tyr Gly Gly Asp Leu Val Phe Thr Ala Phe Ser Gly Ser

360 365 370cac cag gac gct gtg aac aag ggt ctg gac gcc atg gct gcc aag gtt 1267His Gln Asp Ala Val Asn Lys Gly Leu Asp Ala Met Ala Ala Lys Val

375 380 385cag cca ggt gct agc tcc act gaa gtt tct tgg gag cag ctg cgc gac 1315Gln Pro Gly Ala Ser Ser Thr Glu Val Ser Trp Glu Gln Leu Arg Asp390 395 400 405acc gaa tgg gag gtt cct 1333Thr Glu Trp Glu Val Pro

410<210>276<211>411<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>276Met Ser Pro Asn Asp Ala Phe Ile Ser Ala Pro Ala Lys Ile Glu Thr 151015 Pro Val Gly Pro Arg Asn Glu Gly Gln Pro Ala Trp Asn Lys Gln Arg

20 25 30Gly Ser Ser Met Pro Val Asn Arg Tyr Met Pro Phe Glu Val Glu Val

35 40 45Glu Asp Ile Ser Leu Pro Asp Arg Thr Trp Pro Asp Lys Lys Ile Thr

50 55 60Val Ala Pro Gln Trp Cys Ala Val Asp Leu Arg Asp Gly Asn Gln Ala 65 70 75 80Leu Ile Asp Pro Met Ser Pro Glu Arg Lys Arg Arg Met Phe Glu Leu

85 90 95Leu Val Gln Met Gly Phe Lys Glu Ile Glu Val Gly Phe Pro Ser Ala

100 105 110Ser Gln Thr Asp Phe Asp Phe Val Arg Glu Ile Ile Glu Lys Gly Met

115 120 125Ile Pro Asp Asp Val Thr Ile Gln Val Leu Val Gln Ala Arg Glu His

130 135 140Leu Ile Arg Arg Thr Phe Glu Ala Cys Glu Gly Ala Lys Asn Val Ile145 150 155 160Val His Phe Tyr Asn Ser Thr Ser Ile Leu Gln Arg Asn Val Val Phe

165 170 175Arg Met Asp Lys Val Gln Val Lys Lys Leu Ala Thr Asp Ala Ala Glu

180 185 190Leu Ile Lys Thr Ile Ala Gln Asp Tyr Pro Asp Thr Asn Trp Arg Trp

195 200 205Gln Tyr Ser Pro Glu Ser Phe Thr Gly Thr Glu Val Glu Tyr Ala Lys

210 215 220Glu Val Val Asp Ala Val Val Glu Val Met Asp Pro Thr Pro Glu Asn225 230 235 240Pro Met Ile Ile Asn Leu Pro Ser Thr Val Glu Met Ile Thr Pro Asn

245 250 255Val Tyr Ala Asp Ser Ile Glu Trp Met His Arg Asn Leu Asn Arg Arg

260 265 270Asp Ser Ile Ile Leu Ser Leu His Pro His Asn Asp Arg Gly Thr Gly

275 280 285Val Gly Ala Ala Glu Leu Gly Tyr Met Ala Gly Ala Asp Arg Ile Glu

290 295 300Gly Cys Leu Phe Gly Asn Gly Glu Arg Thr Gly Asn Val Cys Leu Val305 310 315 320Thr Leu Ala Leu Asn Met Leu Thr Gln Gly Val Asp Pro Gln Leu Asp

325 330 335Phe Thr Asp Ile Arg Gln Ile Arg Ser Thr Val Glu Tyr Cys Asn Gln

340 345 350Leu Arg Val Pro Glu Arg His Pro Tyr Gly Gly Asp Leu Val Phe Thr

355 360 365Ala Phe Ser Gly Ser His Gln Asp Ala Val Asn Lys Gly Leu Asp Ala

370 375 380Met Ala Ala Lys Val Gln Pro Gly Ala Ser Ser Thr Glu Val Ser Trp385 390 395 400Glu Gln Leu Arg Asp Thr Glu Trp Glu Val Pro

405410<210>277<211>714<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (691)<223>RXN02965<400>277caggaggccg cacccacctg gtatccccag cagtcgcagc cgccaccgaa tccgcggacc 60ctgtcctcac ctgcagatat ctaaggaagg ctagaaaaca atg gaa aaa ttt acc 115

Met Glu Lys Phe Thr

1 5acc tac acc ggc gtt ggc gtt cca ctg cag cga tcc aac gtg gac acc 163Thr Tyr Thr Gly Val Gly Val Pro Leu Gln Arg Ser Asn Val Asp Thr

10 15 20gac cag atc atc cca gcc gtc tac ctc aag cgc gtc acc cgg acc ggc 211Asp Gln Ile Ile Pro Ala Val Tyr Leu Lys Arg Val Thr Arg Thr Gly

25 30 35ttc gaa gac gga ctg ttt tcc aac tgg cgc caa aac gac ccc aac ttt 259Phe Glu Asp Gly Leu Phe Ser Asn Trp Arg Gln Asn Asp Pro Asn Phe

40 45 50gtc ctc aac acc gac acc tac aag aac ggc tcc gtt ctc gta gca ggc 307Val Leu Asn Thr Asp Thr Tyr Lys Asn Gly Ser Val Leu Val Ala Gly

55 60 65cct gac ttt ggc acc ggc tcc tcc cgc gag cac gcc gtc tgg gca ctc 355Pro Asp Phe Gly Thr Gly Ser Ser Arg Glu His Ala Val Trp Ala Leu 70 75 80 85atg gac tac ggc ttc cgc gct gtc ttc tcc tca cga ttc gcc gac atc 403Met Asp Tyr Gly Phe Arg Ala Val Phe Ser Ser Arg Phe Ala Asp Ile

90 95 100ttc cgc ggc aac tcc gga aaa gcg ggc atg ctc acc ggc atc atg gaa 451Phe Arg Gly Asn Ser Gly Lys Ala Gly Met Leu Thr Gly Ile Met Glu

105 110 115cag tcc gac atc gaa ctt ctg tgg aag ctc atg gaa caa acc cca ggc 499Gln Ser Asp Ile Glu Leu Leu Trp Lys Leu Met Glu Gln Thr Pro Gly

120 125 130ctc gaa ctg acc gtg aac ctg gaa aag cag atc gtc acc gca ggc gac 547Leu Glu Leu Thr Val Asn Leu Glu Lys Gln Ile Val Thr Ala Gly Asp

135 140 145gta gtg atc agc ttc gaa gtt gac ccc tac atc cgc tgg cgt ttg atg 595Val Val Ile Ser Phe Glu Val Asp Pro Tyr Ile Arg Trp Arg Leu Met150 155 160 165gaa ggc ctc gac gac gct ggc ctg acc ctg cgc aag ctc gat gaa att 643Glu Gly Leu Asp Asp Ala Gly Leu Thr Leu Arg Lys Leu Asp Glu Ile

170 175 180gaa gac tac gag gct aag cgc cct gcg ttt aag cca cgc act aac gct 691Glu Asp Tyr Glu Ala Lys Arg Pro Ala Phe Lys Pro Arg Thr Asn Ala

185190195 taagtttcag tctgatagcg aaa 714<210>278<211>197<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>278Met Glu Lys Phe Thr Thr Tyr Thr Gly Val Gly Val Pro Leu Gln Arg 151015 Ser Asn Val Asp Thr Asp Gln Ile Ile Pro Ala Val Tyr Leu Lys Arg

20 25 30Val Thr Arg Thr Gly Phe Glu Asp Gly Leu Phe Ser Asn Trp Arg Gln

35 40 45Asn Asp Pro Asn Phe Val Leu Asn Thr Asp Thr Tyr Lys Asn Gly Ser

50 55 60Val Leu Val Ala Gly Pro Asp Phe Gly Thr Gly Ser Ser Arg Glu His

70 75 80Ala Val Trp Ala Leu Met Asp Tyr Gly Phe Arg Ala Val Phe Ser Ser

85 90 95Arg Phe Ala Asp Ile Phe Arg Gly Asn Ser Gly Lys Ala Gly Met Leu

100 105 110Thr Gly Ile Met Glu Gln Ser Asp Ile Glu Leu Leu Trp Lys Leu Met

115 120 125Glu Gln Thr Pro Gly Leu Glu Leu Thr Val Asn Leu Glu Lys Gln Ile

130 135 140Val Thr Ala Gly Asp Val Val Ile Ser Phe Glu Val Asp Pro Tyr Ile145 150 155 160Arg Trp Arg Leu Met Glu Gly Leu Asp Asp Ala Gly Leu Thr Leu Arg

165 170 175Lys Leu Asp Glu Ile Glu Asp Tyr Glu Ala Lys Arg Pro Ala Phe Lys

180 185 190Pro Arg Thr Asn Ala

195<210>279<211>936<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (913)<223>RXN01929<400>279aaaatttgac tccataacga gaacttaatc gagcaacacc cctgaacagt gaatcaaatc 60ggaatttatt tattctgagc tggtcatcac atctatactc atg ccc atg tca ggc 115

Met Pro Met Ser Gly

1 5att gat gca aag aaa atc cgc acc cgt cat ttc cgc gaa gct aaa gta 163Ile Asp Ala Lys Lys Ile Arg Thr Arg His Phe Arg Glu Ala Lys Val

10 15 20aac ggc cag aaa gtt tcg gtt ctc acc agc tat gat gcg ctt tcg gcg 211Asn Gly Gln Lys Val Ser Val Leu Thr Ser Tyr Asp Ala Leu Ser Ala

25 30 35cgc att ttt gat gag gct ggc gtc gat atg ctc ctt gtt ggt gat tcc 259Arg Ile Phe Asp Glu Ala Gly Val Asp Met Leu Leu Val Gly Asp Ser

40 45 50gct gcc aac gtt gtg ctg ggt cgc gat acc acc ttg tcg atc acc ttg 307Ala Ala Asn Val Val Leu Gly Arg Asp Thr Thr Leu Ser Ile Thr Leu

55 60 65gat gag atg att gtg ctg gcc aag gcg gtg acg atc gct acg aag cgt 355Asp Glu Met Ile Val Leu Ala Lys Ala Val Thr Ile Ala Thr Lys Arg 70 75 80 85gcg ctt gtg gtg gtt gat ctg ccg ttt ggt acc tat gag gtg agc cca 403Ala Leu Val Val Val Asp Leu Pro Phe Gly Thr Tyr Glu Val Ser Pro

90 95 100aat cag gcg gtg gag tcc gcg atc cgg gtc atg cgt gaa acg ggt gcg 451Asn Gln Ala Val Glu Ser Ala Ile Arg Val Met Arg Glu Thr Gly Ala

105 110 115gct gcg gtg aag atc gag ggt ggc gtg gag atc gcg cag acg att cga 499Ala Ala Val Lys Ile Glu Gly Gly Val Glu Ile Ala Gln Thr Ile Arg

120 125 130cgc att gtt gat gct gga att ccg gtt gtc ggc cac atc ggg tac acc 547Arg Ile Val Asp Ala Gly Ile Pro Val Val Gly His Ile Gly Tyr Thr

135 140 145ccg cag tcc gag cat tcc ttg ggc ggc cac gtg gtt cag ggt cgt ggc 595Pro Gln Ser Glu His Ser Leu Gly Gly His Val Val Gln Gly Arg Gly150 155 160 165gcg agt tct gga aag ctc atc gcc gat gcc cgc gcg ttg gag cag gcg 643Ala Ser Ser Gly Lys Leu Ile Ala Asp Ala Arg Ala Leu Glu Gln Ala

170 175 180ggt gcg ttt gcg gtt gtg ttg gag atg gtt cca gca gag gca gcg cgc 691Gly Ala Phe Ala Val Val Leu Glu Met Val Pro Ala Glu Ala Ala Arg

185 190 195gag gtt acc gag gat ctt tcc atc acc act atc gga atc ggt gcc ggc 739Glu Val Thr Glu Asp Leu Ser Ile Thr Thr Ile Gly Ile Gly Ala Gly

200 205 210aat ggc aca gat ggg cag gtt ttg gtg tgg cag gat gcc ttc ggc ctc 787Asn Gly Thr Asp Gly Gln Val Leu Val Trp Gln Asp Ala Phe Gly Leu

215 220 225aac cgc ggc aag aag cca cgc ttc gtc cgc gag tac gcc acc ttg ggc 835Asn Arg Gly Lys Lys Pro Arg Phe Val Arg Glu Tyr Ala Thr Leu Gly230 235 240 245gat tcc ttg cac gac gcc gcg cag gcc tac atc gcc gat atc cac gcg 883Asp Ser Leu His Asp Ala Ala Gln Ala Tyr Ile Ala Asp Ile His Ala

250 255 260ggt acc ttc cca ggc gaa gcg gag tcc ttt taatgcaggt agcaaccaca 933Gly Thr Phe Pro Gly Glu Ala Glu Ser Phe

265270 aag 936<210>280<211>271<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>280Met Pro Met Ser Gly Ile Asp Ala Lys Lys Ile Arg Thr Arg His Phe 151015 Arg Glu Ala Lys Val Asn Gly Gln Lys Val Ser Val Leu Thr Ser Tyr

20 25 30Asp Ala Leu Ser Ala Arg Ile Phe Asp Glu Ala Gly Val Asp Met Leu

35 40 45Leu Val Gly Asp Ser Ala Ala Asn Val Val Leu Gly Arg Asp Thr Thr

50 55 60Leu Ser Ile Thr Leu Asp Glu Met Ile Val Leu Ala Lys Ala Val Thr 65 70 75 80Ile Ala Thr Lys Arg Ala Leu Val Val Val Asp Leu Pro Phe Gly Thr

85 9095Tyr Glu Val Ser Pro Asn Gln Ala Val Glu Ser Ala Ile Arg Val Met

100 105 110Arg Glu Thr Gly Ala Ala Ala Val Lys Ile Glu Gly Gly Val Glu Ile

115 120 125Ala Gln Thr Ile Arg Arg Ile Val Asp Ala Gly Ile Pro Val Val Gly

130 135 140His Ile Gly Tyr Thr Pro Gln Ser Glu His Ser Leu Gly Gly His Val145 150 155 160Val Gln Gly Arg Gly Ala Ser Ser Gly Lys Leu Ile Ala Asp Ala Arg

165 170 175Ala Leu Glu Gln Ala Gly Ala Phe Ala Val Val Leu Glu Met Val Pro

180 185 190Ala Glu Ala Ala Arg Glu Val Thr Glu Asp Leu Ser Ile Thr Thr Ile

195 200 205Gly Ile Gly Ala Gly Asn Gly Thr Asp Gly Gln Val Leu Val Trp Gln

210 215 220Asp Ala Phe Gly Leu Asn Arg Gly Lys Lys Pro Arg Phe Val Arg Glu225 230 235 240Tyr Ala Thr Leu Gly Asp Ser Leu His Asp Ala Ala Gln Ala Tyr Ile

245 250 255Ala Asp Ile His Ala Gly Thr Phe Pro Gly Glu Ala Glu Ser Phe

260265270<210>281<211>930<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (907)<223>FRXA01929<400>281tgactccata acgagaactt aatcgagcaa cacccctgaa cagtgaatca aatcggaatt 60tatttattct gagctggtca tcacatctat actcatgccc atg tca ggc att gat 115

Met Ser Gly Ile Asp

1 5gca aag aaa atc cgc acc cgt cat ttc cgc gaa gct aaa gta aac ggc 163Ala Lys Lys Ile Arg Thr Arg His Phe Arg Glu Ala Lys Val Asn Gly

10 15 20cag aaa gtt tcg gtt ctc acc agc tat gat gcg ctt tcg gcg cgc att 211Gln Lys Val Ser Val Leu Thr Ser Tyr Asp Ala Leu Ser Ala Arg Ile

25 30 35ttt gat gag gct ggc gtc gat atg ctc ctt gtt ggt gat tcc gct gcc 259Phe Asp Glu Ala Gly Val Asp Met Leu Leu Val Gly Asp Ser Ala Ala

40 45 50aac gtt gtg ctg ggt cgc gat acc acc ttg tcg atc acc ttg gat gag 307Asn Val Val Leu Gly Arg Asp Thr Thr Leu Ser Ile Thr Leu Asp Glu

55 60 65atg att gtg ctg gcc aag gcg gtg acg atc gct acg aag cgt gcg ctt 355Met Ile Val Leu Ala Lys Ala Val Thr Ile Ala Thr Lys Arg Ala Leu 70 75 80 85gtg gtg gtt gat ctg ccg ttt ggt acc tat gag gtg agc cca aat cag 403Val Val Val Asp Leu Pro Phe Gly Thr Tyr Glu Val Ser Pro Asn Gln

90 95 100gcg gtg gag tcc gcg atc cgg gtc atg cgt gaa acg ggt gcg gct gcg 451Ala Val Glu Ser Ala Ile Arg Val Met Arg Glu Thr Gly Ala Ala Ala

105 110 115gtg aag atc gag ggt ggc gtg gag atc gcg cag acg att cga cgc att 499Val Lys Ile Glu Gly Gly Val Glu Ile Ala Gln Thr Ile Arg Arg Ile

120 125 130gtt gat gct gga att ccg gtt gtc ggc cac atc ggg tac acc ccg cag 547Val Asp Ala Gly Ile Pro Val Val Gly His Ile Gly Tyr Thr Pro Gln

135 140 145tcc gag cat tcc ttg ggc ggc cacgtg gtt cag ggt cgt ggc gcg agt 595Ser Glu His Ser Leu Gly Gly His Val Val Gln Gly Arg Gly Ala Ser150 155 160 165tct gga aag ctc atc gcc gat gcc cgc gcg ttg gag cag gcg ggt gcg 643Ser Gly Lys Leu Ile Ala Asp Ala Arg Ala Leu Glu Gln Ala Gly Ala

170 175 180ttt gcg gtt gtg ttg gag atg gtt cca gca gag gca gcg cgc gag gtt 691Phe Ala Val Val Leu Glu Met Val Pro Ala Glu Ala Ala Arg Glu Val

185 190 195acc gag gat ctt tcc atc acc act atc gga atc ggt gcc ggc aat ggc 739Thr Glu Asp Leu Ser Ile Thr Thr Ile Gly Ile Gly Ala Gly Asn Gly

200 205 210aca gat ggg cag gtt ttg gtg tgg cag gat gcc ttc ggc ctc aac cgc 787Thr Asp Gly Gln Val Leu Val Trp Gln Asp Ala Phe Gly Leu Asn Arg

215 220 225ggc aag aag cca cgc ttc gtc cgc gag tac gcc acc ttg ggc gat tcc 835Gly Lys Lys Pro Arg Phe Val Arg Glu Tyr Ala Thr Leu Gly Asp Ser230 235 240 245ttg cac gac gcc gcg cag gcc tac atc gcc gat atc cac gcg ggt acc 883Leu His Asp Ala Ala Gln Ala Tyr Ile Ala Asp Ile His Ala Gly Thr

250 255 260ttc cca ggc gaa gcg gag tcc ttt taatgcaggt agcaaccaca aag 930Phe Pro Gly Glu Ala Glu Ser Phe

265<210>282<211>269<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>282Met Ser Gly Ile Asp Ala Lys Lys Ile Arg Thr Arg His Phe Arg Glu 151015 Ala Lys Val Asn Gly Gln Lys Val Ser Val Leu Thr Ser Tyr Asp Ala

20 25 30Leu Ser Ala Arg Ile Phe Asp Glu Ala Gly Val Asp Met Leu Leu Val

35 40 45Gly Asp Ser Ala Ala Asn Val Val Leu Gly Arg Asp Thr Thr Leu Ser

50 55 60Ile Thr Leu Asp Glu Met Ile Val Leu Ala Lys Ala Val Thr Ile Ala 65 70 75 80Thr Lys Arg Ala Leu Val Val Val Asp Leu Pro Phe Gly Thr Tyr Glu

85 90 95Val Ser Pro Asn Gln Ala Val Glu Ser Ala Ile Arg Val Met Arg Glu

100 105 110Thr Gly Ala Ala Ala Val Lys Ile Glu Gly Gly Val Glu Ile Ala Gln

115 120 125Thr Ile Arg Arg Ile Val Asp Ala Gly Ile Pro Val Val Gly His Ile

130 135 140Gly Tyr Thr Pro Gln Ser Glu His Ser Leu Gly Gly His Val Val Gln145 150 155 160Gly Arg Gly Ala Ser Ser Gly Lys Leu Ile Ala Asp Ala Arg Ala Leu

165 170 175Glu Gln Ala Gly Ala Phe Ala Val Val Leu Glu Met Val Pro Ala Glu

180 185 190Ala Ala Arg Glu Val Thr Glu Asp Leu Ser Ile Thr Thr Ile Gly Ile

195 200 205Gly Ala Gly Asn Gly Thr Asp Gly Gln Val Leu Val Trp Gln Asp Ala

210 215 220Phe Gly Leu Asn Arg Gly Lys Lys Pro Arg Phe Val Arg Glu Tyr Ala225 230 235 240Thr Leu Gly Asp Ser Leu His Asp Ala Ala Gln Ala Tyr Ile Ala Asp

245 250 255Ile His Ala Gly Thr Phe Pro Gly Glu Ala Glu Ser Phe

260265<210>283<211>1065<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).)

Val Thr Leu Gly Gly

1 5ttg aat gta cca tcg tgg tcg ctg ggc gcg gaa atg ctg ttc tac ctg 163Leu Asn Val Pro Ser Trp Ser Leu Gly Ala Glu Met Leu Phe Tyr Leu

10 15 20acg ttc ccg ctg ttt att ccg tta gtg cgc aaa gtg aag ggc gtg ggc 211Thr Phe Pro Leu Phe Ile Pro Leu Val Arg Lys Val Lys Gly Val Gly

25 30 35aac tgg tgg gca ttt ggc atc acc ttt gcc gtg agc ctg gcg ctg att 259Asn Trp Trp Ala Phe Gly Ile Thr Phe Ala Val Ser Leu Ala Leu Ile

40 45 50aca gtg att cac ttt tat gcg gac gga cca aag ggg att gag aac ttc 307Thr Val Ile His Phe Tyr Ala Asp Gly Pro Lys Gly Ile Glu Asn Phe

55 60 65ttt gtt cct cgc ctg tgg gac acc aat gtg tca ccg gtc gcg gaa gtt 355Phe Val Pro Arg Leu Trp Asp Thr Asn Val Ser Pro Val Ala Glu Val 70 75 80 85cac gcc gat cca gtg tgg ttt atg cag gaa gaa att ccc gtg ctg gaa 403His Ala Asp Pro Val Trp Phe Met Gln Glu Glu Ile Pro Val Leu Glu

90 95 100tct tac tgg ctg tct tac tac ttc ccg ctg acc aga ctc atc gag ttc 451Ser Tyr Trp Leu Ser Tyr Tyr Phe Pro Leu Thr Arg Leu Ile Glu Phe

105 110 115tac ctc ggt gtg ttt ggc gcg aag ctg gtt gct gaa ggc atg ttt aaa 499Tyr Leu Gly Val Phe Gly Ala Lys Leu Val Ala Glu Gly Met Phe Lys

120125 130aac acc aac atc acc atc ccg ctg atc gca ctg gct gtt tct ttt gtt 547Asn Thr Asn Ile Thr Ile Pro Leu Ile Ala Leu Ala Val Ser Phe Val

135 140 145gct act tgg ttt gtg cca ctg gca ttc aag atg tct gtc atc atg tcc 595Ala Thr Trp Phe Val Pro Leu Ala Phe Lys Met Ser Val Ile Met Ser150 155 160 165ctg cca atg gct ttt gtt gtg gca acg ctt gcg gtg aga gac att gaa 643Leu Pro Met Ala Phe Val Val Ala Thr Leu Ala Val Arg Asp Ile Glu

170 175 180ggc aag agt ggg gaa atc gcc tcg cct cgc gca gtt ttg ttg ggt aat 691Gly Lys Ser Gly Glu Ile Ala Ser Pro Arg Ala Val Leu Leu Gly Asn

185 190 195att tcc ttt gcc ttc tac atg gtg caa ttc ccc gtc atg gtg ttt gtg 739Ile Ser Phe Ala Phe Tyr Met Val Gln Phe Pro Val Met Val Phe Val

200 205 210cag cgc tat ttc att gct ggc aaa gaa tac ggc ttc ctt ggc tgg gca 787Gln Arg Tyr Phe Ile Ala Gly Lys Glu Tyr Gly Phe Leu Gly Trp Ala

215 220 225ttc tat gca gtg gtg tgt ttc atc gtg tcg gtc att ctc gcg tgg gtg 835Phe Tyr Ala Val Val Cys Phe Ile Val Ser Val Ile Leu Ala Trp Val230 235 240 245ctg ttt acc ttc gtt gat gat cct ttg atg aag gcc acg gcg cgc aag 883Leu Phe Thr Phe Val Asp Asp Pro Leu Met Lys Ala Thr Ala Arg Lys

250 255 260aag ggg agt agg cgc ttg aag cag tcc aat att ttg gtc cgt gac ctg 931Lys Gly Ser Arg Arg Leu Lys Gln Ser Asn Ile Leu Val Arg Asp Leu

265 270 275aaa gtt ctc ttc ggc aaa agc ccc gaa aag ccg tta aaa gtt gag act 979Lys ValLeu Phe Gly Lys Ser Pro Glu Lys Pro Leu Lys Val Glu Thr

280 285 290cgc gct gag aat ctc aca gaa aac tcc gaa gct ccc gct aag gta gct 1027Arg Ala Glu Asn Leu Thr Glu Asn Ser Glu Ala Pro Ala Lys Val Ala

295300305 acc gga atc aaa tct tagggaagga aaacatatgg cta 1065Thr Gly Ile Lys Ser310<210>284<211>314<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>284Val Thr Leu Gly Gly Leu Asn Val Pro Ser Trp Ser Leu Gly Ala Glu 151015 Met Leu Phe Tyr Leu Thr Phe Pro Leu Phe Ile Pro Leu Val Arg Lys

20 25 30Val Lys Gly Val Gly Asn Trp Trp Ala Phe Gly Ile Thr Phe Ala Val

35 40 45Ser Leu Ala Leu Ile Thr Val Ile His Phe Tyr Ala Asp Gly Pro Lys

50 55 60Gly Ile Glu Asn Phe Phe Val Pro Arg Leu Trp Asp Thr Asn Val Ser 65 70 75 80Pro Val Ala Glu Val His Ala Asp Pro Val Trp Phe Met Gln Glu Glu

85 90 95Ile Pro Val Leu Glu Ser Tyr Trp Leu Ser Tyr Tyr Phe Pro Leu Thr

100 105 110Arg Leu Ile Glu Phe Tyr Leu Gly Val Phe Gly Ala Lys Leu Val Ala

115 120 125Glu Gly Met Phe Lys Asn Thr Asn Ile Thr Ile Pro Leu Ile Ala Leu

130 135 140Ala Val Ser Phe Val Ala Thr Trp Phe Val Pro Leu Ala Phe Lys Met145 150 155 160Ser Val Ile Met Ser Leu Pro Met Ala Phe Val Val Ala Thr Leu Ala

165 170 175Val Arg Asp Ile Glu Gly Lys Ser Gly Glu Ile Ala Ser Pro Arg Ala

180 185 190Val Leu Leu Gly Asn Ile Ser Phe Ala Phe Tyr Met Val Gln Phe Pro

195 200 205Val Met Val Phe Val Gln Arg Tyr Phe Ile Ala Gly Lys Glu Tyr Gly

210 215 220Phe Leu Gly Trp Ala Phe Tyr Ala Val Val Cys Phe Ile Val Ser Val225 230 235 240Ile Leu Ala Trp Val Leu Phe Thr Phe Val Asp Asp Pro Leu Met Lys

245 250 255Ala Thr Ala Arg Lys Lys Gly Ser Arg Arg Leu Lys Gln Ser Asn Ile

260 265 270Leu Val Arg Asp Leu Lys Val Leu Phe Gly Lys Ser Pro Glu Lys Pro

275 280 285Leu Lys Val Glu Thr Arg Ala Glu Asn Leu Thr Glu Asn Ser Glu Ala

290295300 Pro Ala Lys Val Ala Thr Gly Ile Lys Ser 305310<210>285<211>1137<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1114)<223>RXS01145<400>285taatgtagtt gtctgcccaa gcgagttaaa ctcccacgat ttacagtggg gggcagacat 60cttttcacca aaatttttac gaaaggcgag attttctccc atg gct att gaa ctg 115

Met Ala Ile Glu Leu

1 5ctt tat gat gct gac gct gac ctc tcc ttg atc cag ggc cgt aag gtt 163Leu Tyr Asp Ala Asp Ala Asp Leu Ser Leu Ile Gln Gly Arg Lys Val

10 15 20gcc atc gtt ggc tac ggc tcc cag ggc cac gca cac tcc cag aac ctc 211Ala Ile Val Gly Tyr Gly Ser Gln Gly His Ala His Ser Gln Asn Leu

25 30 35cgc gat tct ggc gtt gag gtt gtc att ggt ctg cgc gag ggc tcc aag 259Arg Asp Ser Gly Val Glu Val Val Ile Gly Leu Arg Glu Gly Ser Lys

40 45 50tcc gca gag aag gca aag gaa gca ggc ttc gag gtc aag acc acc gct 307Ser Ala Glu Lys Ala Lys Glu Ala Gly Phe Glu Val Lys Thr Thr Ala

55 60 65gag gct gca gct tgg gct gac gtc atc atg ctc ctg gct cca gac acc 355Glu Ala Ala Ala Trp Ala Asp Val Ile Met Leu Leu Ala Pro Asp Thr 70 75 80 85tcc cag gca gaa atc ttc acc aac gac atc gag cca aac ctg aac gca 403Ser Gln Ala Glu Ile Phe Thr Asn Asp Ile Glu Pro Asn Leu Asn Ala

90 95 100ggc gac gca ctg ctg ttc ggc cac ggc ctg aac att cac ttc gac ctg 451Gly Asp Ala Leu Leu Phe Gly His Gly Leu Asn Ile His Phe Asp Leu

105 110 115atc aag cca gct gac gac atc atc gtt ggc atg gtt gcg cca aag ggc 499Ile Lys Pro Ala Asp Asp Ile Ile Val Gly Met Val Ala Pro Lys Gly

120 125 130cca ggc cac ttg gtt cgc cgt cag ttc gtt gat ggc aag ggt gtt cct 547Pro Gly His Leu Val Arg Arg Gln Phe Val Asp Gly Lys Gly Val Pro

135 140 145tgc ctc atc gca gtc gac cag gac cca acc gga acc gca cag gct ctg 595Cys Leu Ile Ala Val Asp Gln Asp Pro Thr Gly Thr Ala Gln Ala Leu150 155 160 165acc ctg tcc tac gca gca gca atc ggt ggc gca cgc gca ggc gtt atc 643Thr Leu Ser Tyr Ala Ala Ala Ile Gly Gly Ala Arg Ala Gly Val Ile

170 175 180cca acc acc ttc gaa gct gag acc gtc acc gac ctc ttc ggc gag cag 691Pro Thr Thr Phe Glu Ala Glu Thr Val Thr Asp Leu Phe Gly Glu Gln

185 190 195gct gtt ctc tgc ggt ggc acc gag gaa ctg gtc aag gtt ggc ttc gag 739Ala Val Leu Cys Gly Gly Thr Glu Glu Leu Val Lys Val Gly Phe Glu

200 205 210gtt ctc acc gaa gct ggc tac gag cca gag atg gca tac ttc gag gtt 787Val Leu Thr Glu Ala Gly Tyr Glu Pro Glu Met Ala Tyr Phe Glu Val

215 220 225ctt cac gag ctc aag ctc atc gtt gac ctc atg ttc gaa ggt ggc atc 835Leu His Glu Leu Lys Leu Ile Val Asp Leu Met Phe Glu Gly Gly Ile230 235 240 245agc aac atg aac tac tct gtt tct gac acc gct gag ttc ggt ggc tac 883Ser Asn Met Asn Tyr Ser Val Ser Asp Thr Ala Glu Phe Gly Gly Tyr

250 255 260ctc tcc ggc cca cgc gtc atc gat gca gac acc aag tcc cgc atg aag 931Leu Ser Gly Pro Arg Val Ile Asp Ala Asp Thr Lys Ser Arg Met Lys

265 270 275gac atc ctg acc gat atc cag gac ggc acc ttc acc aag cgc ctc atc 979Asp Ile Leu Thr Asp Ile Gln Asp Gly Thr Phe Thr Lys Arg Leu Ile

280 285 290gca aac gtt gag aac ggc aac acc gag ctt gag ggc ctt cgt gct tcc 1027Ala Asn Val Glu Asn Gly Asn Thr Glu Leu Glu Gly Leu Arg Ala Ser

295 300 305tac aac aac cac cca atc gag gag acc ggc gct aag ctc cgc gac ctc 1075Tyr Asn Asn His Pro Ile Glu Glu Thr Gly Ala Lys Leu Arg Asp Leu310 315 320 325atg agc tgg gtc aag gtt gac gct cgc gca gaa acc gct taagtttcac 1124Met Ser Trp Val Lys Val Asp Ala Arg Ala Glu ThrAla

330335 ccctttgacg gct 1137<210>286<211>338<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>286Met Ala Ile Glu Leu Leu Tyr Asp Ala Asp Ala Asp Leu Ser Leu Ile 151015 Gln Gly Arg Lys Val Ala Ile Val Gly Tyr Gly Ser Gln Gly His Ala

20 25 30His Ser Gln Asn Leu Arg Asp Ser Gly Val Glu Val Val Ile Gly Leu

35 40 45Arg Glu Gly Ser Lys Ser Ala Glu Lys Ala Lys Glu Ala Gly Phe Glu

50 55 60Val Lys Thr Thr Ala Glu Ala Ala Ala Trp Ala Asp Val Ile Met Leu 65 70 75 80Leu Ala Pro Asp Thr Ser Gln Ala Glu Ile Phe Thr Asn Asp Ile Glu

85 90 95Pro Asn Leu Asn Ala Gly Asp Ala Leu Leu Phe Gly His Gly Leu Asn

100 105 110Ile His Phe Asp Leu Ile Lys Pro Ala Asp Asp Ile Ile Val Gly Met

115 120 125Val Ala Pro Lys Gly Pro Gly His Leu Val Arg Arg Gln Phe Val Asp

130 135 140Gly Lys Gly Val Pro Cys Leu Ile Ala Val Asp Gln Asp Pro Thr Gly145 150 155 160Thr Ala Gln Ala Leu Thr Leu Ser Tyr Ala Ala Ala Ile Gly Gly Ala

165 170 175Arg Ala Gly Val Ile Pro Thr Thr Phe Glu Ala Glu Thr Val Thr Asp

180 185 190Leu Phe Gly Glu Gln Ala Val Leu Cys Gly Gly Thr Glu Glu Leu Val

195 200 205Lys Val Gly Phe Glu Val Leu Thr Glu Ala Gly Tyr Glu Pro Glu Met

210 215 220Ala Tyr Phe Glu Val Leu His Glu Leu Lys Leu Ile Val Asp Leu Met225 230 235 240Phe Glu Gly Gly Ile Ser Asn Met Asn Tyr Ser Val Ser Asp Thr Ala

245 250 255Glu Phe Gly Gly Tyr Leu Ser Gly Pro Arg Val Ile Asp Ala Asp Thr

260 265 270Lys Ser Arg Met Lys Asp Ile Leu Thr Asp Ile Gln Asp Gly Thr Phe

275 280 285Thr Lys Arg Leu Ile Ala Asn Val Glu Asn Gly Asn Thr Glu Leu Glu

290 295 300Gly Leu Arg Ala Ser Tyr Asn Asn His Pro Ile Glu Glu Thr Gly Ala305 310 315 320Lys Leu Arg Asp Leu Met Ser Trp Val Lys Val Asp Ala Arg Ala Glu

325330335 Thr Ala<210>287<211>556<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (556)<223>FRXA01145<400>287taatgtagtt gtctgcccaa gcgagttaaa ctcccacgat ttacagtggg gggcagacat 60cttttcacca aaatttttac gaaaggcgag attttctccc atg gct att gaa ctg 115

Met Ala Ile Glu Leu

1 5ctt tat gat gct gac gct gac ctc tcc ttg atc cag ggc cgt aag gtt 163Leu Tyr Asp Ala Asp Ala Asp Leu Ser Leu Ile Gln Gly Arg Lys Val

10 15 20gcc atc gtt ggc tac ggc tcc cag ggc cac gca cac tcc cag aac ctc 211Ala Ile Val Gly Tyr Gly Ser Gln Gly His Ala His Ser Gln Asn Leu

2530 35cgc gat tct ggc gtt gag gtt gtc att ggt ctg cgc gag ggc tcc aag 259Arg Asp Ser Gly Val Glu Val Val Ile Gly Leu Arg Glu Gly Ser Lys

40 45 50tcc gca gag aag gca aag gaa gca ggc ttc gag gtc aag acc acc gct 307Ser Ala Glu Lys Ala Lys Glu Ala Gly Phe Glu Val Lys Thr Thr Ala

55 60 65gag gct gca gct tgg gct gac gtc atc atg ctc ctg gct cca gac acc 355Glu Ala Ala Ala Trp Ala Asp Val Ile Met Leu Leu Ala Pro Asp Thr 70 75 80 85tcc cag gca gaa atc ttc acc aac gac atc gag cca aac ctg aac gca 403Ser Gln Ala Glu Ile Phe Thr Asn Asp Ile Glu Pro Asn Leu Asn Ala

90 95 100ggc gac gca ctg ctg ttc ggc cac ggc ctg aac att cac ttc gac ctg 451Gly Asp Ala Leu Leu Phe Gly His Gly Leu Asn Ile His Phe Asp Leu

105 110 115atc aag cca gct gac gac atc atc gtt ggc atg gtt gcg cca aag ggc 499Ile Lys Pro Ala Asp Asp Ile Ile Val Gly Met Val Ala Pro Lys Gly

120 125 130cca ggc cac ttg gtt cgc cgt cag ttc gtt gat ggc aag ggt gtt cct 547Pro Gly His Leu Val Arg Arg Gln Phe Val Asp Gly Lys Gly Val Pro

135140145 tgc ctc atc 556Cys Leu Ile150<210>288<211>152<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>288Met Ala Ile Glu Leu Leu Tyr Asp Ala Asp Ala Asp Leu Ser Leu Ile 151015 Gln Gly Arg Lys Val Ala Ile Val Gly Tyr Gly Ser Gln Gly His Ala

20 25 30His Ser Gln Asn Leu Arg Asp Ser Gly Val Glu Val Val Ile Gly Leu

35 40 45Arg Glu Gly Ser LysSer Ala Glu Lys Ala Lys Glu Ala Gly Phe Glu

50 55 60Val Lys Thr Thr Ala Glu Ala Ala Ala Trp Ala Asp Val Ile Met Leu 65 70 75 80Leu Ala Pro Asp Thr Ser Gln Ala Glu Ile Phe Thr Asn Asp Ile Glu

85 90 95Pro Asn Leu Asn Ala Gly Asp Ala Leu Leu Phe Gly His Gly Leu Asn

100 105 110Ile His Phe Asp Leu Ile Lys Pro Ala Asp Asp Ile Ile Val Gly Met

115 120 125Val Ala Pro Lys Gly Pro Gly His Leu Val Arg Arg Gln Phe Val Asp

130135140 Gly Lys Gly Val Pro Cys Leu Ile 145150<210>289<211>1350<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<1327><223>RXA02375<400>289cttttcaggt ctacgtgtat acgatggtaa cgctatgaat gatacgcaga acacacctga 60aagcgttcga ttacgggata atctcccaac gccaacccaa atg gcg ccg gtg aca 115

Met Ala Pro Val Thr

1 5ggg ctt cct gtc acc ccc tac agc cag gaa gca agc atc ggt gcg agc 163Gly Leu Pro Val Thr Pro Tyr Ser Gln Glu Ala Ser Ile Gly Ala Ser

10 15 20ttc ccg gca gtg gat ccg gac acc aaa gac agc gcc gca tac gga cat 211Phe Pro Ala Val Asp Pro Asp Thr Lys Asp Ser Ala Ala Tyr Gly His

25 30 35gaa tcc gga atg cgt gag cgc atc tcc aac gct aag cga gtg gtg gtg 259Glu Ser Gly Met Arg Glu Arg Ile Ser Asn Ala Lys Arg Val Val Val

40 4550aaa att ggt tcg tcc tca ttg act aac gat gag gac gga cac acc gtc 307Lys Ile Gly Ser Ser Ser Leu Thr Asn Asp Glu Asp Gly His Thr Val

55 60 65gat ccc aac cgc atc aac act att gtc aat gcc ttg caa gca cgc atg 355Asp Pro Asn Arg Ile Asn Thr Ile Val Asn Ala Leu Gln Ala Arg Met 70 75 80 85gaa gct ggc tcg gac ctc atc gtt gtg tcc tct ggc gca gtg gcc gcg 403Glu Ala Gly Ser Asp Leu Ile Val Val Ser Ser Gly Ala Val Ala Ala

90 95 100gga atg gcc ccg ctt gga ttg agc acc cgg ccc acg gaa ttg gca gtc 451Gly Met Ala Pro Leu Gly Leu Ser Thr Arg Pro Thr Glu Leu Ala Val

105 110 115aag cag gct gca gca gca gtg ggg caa gtt cac ctc atg cac cag tgg 499Lys Gln Ala Ala Ala Ala Val Gly Gln Val His Leu Met His Gln Trp

120 125 130gga cgt tct ttt gcc cgg tat ggt cgc ccc atc ggc cag gtg ctt ctt 547Gly Arg Ser Phe Ala Arg Tyr Gly Arg Pro Ile Gly Gln Val Leu Leu

135 140 145acc gca gct gat gca gga aag cgt gat cgt gcg agg aat gcg cag cgt 595Thr Ala Ala Asp Ala Gly Lys Arg Asp Arg Ala Arg Asn Ala Gln Arg150 155 160 165acc atc gac aag ctg cgc att ttg ggc gcg gtt cct atc gtc aat gaa 643Thr Ile Asp Lys Leu Arg Ile Leu Gly Ala Val Pro Ile Val Asn Glu

170 175 180aat gac acc gtg gca acc acc ggt gtg aat ttt ggt gac aac gac cga 691Asn Asp Thr Val Ala Thr Thr Gly Val Asn Phe Gly Asp Asn Asp Arg

185 190 195ctt gct gca att gtg gcg cac ctg gtg tcg gct gat gct ttg gtg ctg 739Leu Ala Ala Ile Val Ala HisLeu Val Ser Ala Asp Ala Leu Val Leu

200 205 210ctc agt gac gtg gat gga ctt ttt gat aaa aac cct act gat ccc acc 787Leu Ser Asp Val Asp Gly Leu Phe Asp Lys Asn Pro Thr Asp Pro Thr

215 220 225gcg aag ttt att tcc gag gtt cgt gac ggc aat gat ttg aaa ggt gtc 835Ala Lys Phe Ile Ser Glu Val Arg Asp Gly Asn Asp Leu Lys Gly Val230 235 240 245att gcc ggc gac ggc gga aaa gtg ggc acc ggt ggc atg gca tca aag 883Ile Ala Gly Asp Gly Gly Lys Val Gly Thr Gly Gly Met Ala Ser Lys

250 255 260gtg tct gct gca cgt ttg gct tcc cga agt ggc gtg cct gtg ctg ttg 931Val Ser Ala Ala Arg Leu Ala Ser Arg Ser Gly Val Pro Val Leu Leu

265 270 275acc tct gcg gca aac att ggc cca gca ctg gaa gac gcc cag gtg ggc 979Thr Ser Ala Ala Asn Ile Gly Pro Ala Leu Glu Asp Ala Gln Val Gly

280 285 290act gta ttc cac ccc aag gac aac cgc ctc tcc gcg tgg aag ttc tgg 1027Thr Val Phe His Pro Lys Asp Asn Arg Leu Ser Ala Trp Lys Phe Trp

295 300 305gct ttg tat gcc gca gat act gca gga aag atc cga ctc gat gac ggc 1075Ala Leu Tyr Ala Ala Asp Thr Ala Gly Lys Ile Arg Leu Asp Asp Gly310 315 320 325gcg gtg gaa gca gtg acc tcc ggt ggt aaa tct ttg ctg gct gtg ggc 1123Ala Val Glu Ala Val Thr Ser Gly Gly Lys Ser Leu Leu Ala Val Gly

330 335 340att act gaa atc att ggt gat ttc cag cag ggt gag atc gtg gag atc 1171Ile Thr Glu Ile Ile Gly Asp Phe Gln Gln Gly Glu Ile Val Glu Ile

345 350355ttg gga cct gcc ggc caa atc atc ggg cga ggc gag gtg tcc tac gat 1219Leu Gly Pro Ala Gly Gln Ile Ile Gly Arg Gly Glu Val Ser Tyr Asp

360 365 370tct gat acc ttg caa tca atg gtt ggt atg caa acg cag gac ctt cca 1267Ser Asp Thr Leu Gln Ser Met Val Gly Met Gln Thr Gln Asp Leu Pro

375380385 gat ggc atg cag cgc ccg gta gtg cat gca gat tat ctg tcc aac tac 1315Asp Gly Met Gln Arg Pro Val Val His Ala Asp Tyr Leu Ser Asn Tyr 390395400405 gcc agc cgc gcg taaagcgcgg gcctgctggt ggc 1350Ala Ser Arg Ala<210>290<211>409<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>290Met Ala Pro Val Thr Gly Leu Pro Val Thr Pro Tyr Ser Gln Glu Ala 151015 Ser Ile Gly Ala Ser Phe Pro Ala Val Asp Pro Asp Thr Lys Asp Ser

20 25 30Ala Ala Tyr Gly His Glu Ser Gly Met Arg Glu Arg Ile Ser Asn Ala

35 40 45Lys Arg Val Val Val Lys Ile Gly Ser Ser Ser Leu Thr Asn Asp Glu

50 55 60Asp Gly His Thr Val Asp Pro Asn Arg Ile Asn Thr Ile Val Asn Ala 65 70 75 80Leu Gln Ala Arg Met Glu Ala Gly Ser Asp Leu Ile Val Val Ser Ser

85 90 95Gly Ala Val Ala Ala Gly Met Ala Pro Leu Gly Leu Ser Thr Arg Pro

100 105 110Thr Glu Leu Ala Val Lys Gln Ala Ala Ala Ala Val Gly Gln Val His

115 120 125Leu Met His Gln Trp Gly Arg Ser Phe Ala Arg Tyr Gly Arg Pro Ile

130 135 140Gly Gln Val Leu Leu Thr Ala Ala Asp Ala Gly Lys Arg Asp Arg Ala145 150 155 160Arg Asn Ala Gln Arg Thr Ile Asp Lys Leu Arg Ile Leu Gly Ala Val

165 170 175Pro Ile Val Asn Glu Asn Asp Thr Val Ala Thr Thr Gly Val Asn Phe

180 185 190Gly Asp Asn Asp Arg Leu Ala Ala Ile Val Ala His Leu Val Ser Ala

195 200 205Asp Ala Leu Val Leu Leu Ser Asp Val Asp Gly Leu Phe Asp Lys Asn

210 215 220Pro Thr Asp Pro Thr Ala Lys Phe Ile Ser Glu Val Arg Asp Gly Asn225 230 235 240Asp Leu Lys Gly Val Ile Ala Gly Asp Gly Gly Lys Val Gly Thr Gly

245 250 255Gly Met Ala Ser Lys Val Ser Ala Ala Arg Leu Ala Ser Arg Ser Gly

260 265 270Val Pro Val Leu Leu Thr Ser Ala Ala Asn Ile Gly Pro Ala Leu Glu

275 280 285Asp Ala Gln Val Gly Thr Val Phe His Pro Lys Asp Asn Arg Leu Ser

290 295 300Ala Trp Lys Phe Trp Ala Leu Tyr Ala Ala Asp Thr Ala Gly Lys Ile305 310 315 320Arg Leu Asp Asp Gly Ala Val Glu Ala Val Thr Ser Gly Gly Lys Ser

325 330 335Leu Leu Ala Val Gly Ile Thr Glu Ile Ile Gly Asp Phe Gln Gln Gly

340 345 350Glu Ile Val Glu Ile Leu Gly Pro Ala Gly Gln Ile Ile Gly Arg Gly

355 360 365Glu Val Ser Tyr Asp Ser Asp Thr Leu Gln Ser Met Val Gly Met Gln

370 375 380Thr Gln Asp Leu Pro Asp Gly Met Gln Arg Pro Val Val His Ala Asp385 390 395 400Tyr Leu Ser Asn Tyr Ala Ser Arg Ala

405<210>291<211>1419<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1396)<223>RXN02382<400>291gagcagatgg ccaccgaggt cgatgtggtg gctggctact aggcctttta tggtgtgatc 60cgacactgtt gcttcttaag ggtctgtata gtgggcaacc atg agt tca acg acc 115

Met Ser Ser Thr Thr

1 5cta act gat gac caa att cgc gac aat gag cgg acc gaa gtt cta gct 163Leu Thr Asp Asp Gln Ile Arg Asp Asn Glu Arg Thr Glu Val Leu Ala

10 15 20aaa gca act gca gct aag aac atc gtc ccg gat att gca gtg ttg ggc 211Lys Ala Thr Ala Ala Lys Asn Ile Val Pro Asp Ile Ala Val Leu Gly

25 30 35acc gga ccg aag aac gca atc ctg cgt gcg gcg gca gat gaa ctc gtt 259Thr Gly Pro Lys Asn Ala Ile Leu Arg Ala Ala Ala Asp Glu Leu Val

40 45 50gca cgc agc gca gaa atc atc gaa gcc aac gct tcc gat atc gaa gcg 307Ala Arg Ser Ala Glu Ile Ile Glu Ala Asn Ala Ser Asp Ile Glu Ala

55 60 65ggt cgc gca aac ggc atg gaa gaa tcc atg att gat cgc ctt gcc ctt 355Gly Arg Ala Asn Gly Met Glu Glu Ser Met Ile Asp Arg Leu Ala Leu 70 75 80 85gat gaa tct cgc att gag ggc atc gct ggc ggt ttg cgc cag gtt gct 403Asp Glu Ser Arg Ile Glu Gly Ile Ala Gly Gly Leu Arg Gln Val Ala

90 95 100ggc ctg acc gac cca gtg ggt gaa gta ctg cgc gga cat gtc atg gaa 451Gly Leu Thr Asp Pro Val Gly Glu Val Leu Arg Gly His Val Met Glu

105 110 115aac ggc att cag atg aag cag gtc cgt gtg cct ttg ggc gtg atg ggc 499Asn Gly Ile Gln Met Lys Gln Val Arg Val Pro Leu Gly Val Met Gly

120 125 130atg gtc tat gaa gcc cgc cct aac gtc acc gtc gac gcc ttc ggc ctg 547Met Val Tyr Glu Ala Arg Pro Asn Val Thr Val Asp Ala Phe Gly Leu

135 140 145gca ctc aag tcc gga aac gta gct ttg ctg cgc ggt tcc tcc aca gct 595Ala Leu Lys Ser Gly Asn Val Ala Leu Leu Arg Gly Ser Ser Thr Ala150 155 160 165gtg cat tcc aac acc aag ctc gtg gaa atc ctg cag gac gtc ctc gag 643Val His Ser Asn Thr Lys Leu Val Glu Ile Leu Gln Asp Val Leu Glu

170 175 180cgt ttc gag ctg cca cgc gaa acc gtg cag ttg ctg cct tgc caa acc 691Arg Phe Glu Leu Pro Arg Glu Thr Val Gln Leu Leu Pro Cys Gln Thr

185 190 195cgc gga tcc gtc caa gat ttg atc acc gca cgc ggc ctc gtt gac gtg 739Arg Gly Ser Val Gln Asp Leu Ile Thr Ala Arg Gly Leu Val Asp Val

200 205 210gtc atc cca cgc ggc ggc gca gga cta atc aac gca gtg gtc acc ggt 787Val Ile Pro Arg Gly Gly Ala Gly Leu Ile Asn Ala Val Val Thr Gly

215 220 225gcg acc gtg ccc acc att gaa acc ggc acc ggc aac tgc cac ttc tac 835Ala Thr Val Pro Thr Ile Glu Thr Gly Thr Gly Asn Cys His Phe Tyr230 235 240 245atc gat gcc gaa gcc aag ctt gat cag gca atc gcc atg gtc atc aac 883Ile Asp Ala Glu Ala Lys Leu Asp Gln Ala Ile Ala Met Val Ile Asn

250 255 260ggc aag acc cgc cgc tgc agc gtg tgc aac gct act gaa acc gcg ctt 931Gly Lys Thr Arg Arg Cys Ser Val Cys Asn Ala Thr Glu Thr Ala Leu

265 270 275ctc gac gcc gcc ctc agc gac tca gac aag ctt gca gtc gtc cag gcg 979Leu Asp Ala Ala Leu Ser Asp Ser Asp Lys Leu Ala Val Val Gln Ala

280 285 290ctc cag gaa gca gga gtc aca att cat gga cgg gtg gcc gaa ttg gaa 1027Leu Gln Glu Ala Gly Val Thr Ile His Gly Arg Val Ala Glu Leu Glu

295 300 305gca ttc ggt gca acc gac gtg gtg gaa gca act gaa act gac tgg gat 1075Ala Phe Gly Ala Thr Asp Val Val Glu Ala Thr Glu Thr Asp Trp Asp310 315 320 325tct gag tac ctg tcc ttc gat atc gct gtc gct gtg gtt gac ggt gtg 1123Ser Glu Tyr Leu Ser Phe Asp Ile Ala Val Ala Val Val Asp Gly Val

330 335 340gat gga gct ctg gca cac atc gct aag tac agc acc aag cac acc gaa 1171Asp Gly Ala Leu Ala His Ile Ala Lys Tyr Ser Thr Lys His Thr Glu

345 350 355gcg atc gcc acc caa aac att gaa acc gct cag cgc ttt gca gat cgc 1219Ala Ile Ala Thr Gln Asn Ile Glu Thr Ala Gln Arg Phe Ala Asp Arg

360 365 370gtc gat gca gca gcg gtg atg ata aac gca tcc acc gcc tac acc gat 1267Val Asp Ala Ala Ala Val Met Ile Asn Ala Ser Thr Ala Tyr Thr Asp

375 380 385ggg gag cag tac ggc atg ggc gcg gag atc ggc att tcc acc cag aaa 1315Gly Glu Gln Tyr Gly Met Gly Ala Glu Ile Gly Ile Ser Thr Gln Lys390395 400 405ctg cat gca cgt gga cca atg gcc ctg cca gag ctg acc tcc acc aag 1363Leu His Ala Arg Gly Pro Met Ala Leu Pro Glu Leu Thr Ser Thr Lys

410 415 420tgg att ctg cag ggc aca gga caa att agg cct taagtttgaa gaagtaatca 1416Trp Ile Leu Gln Gly Thr Gly Gln Ile Arg Pro

425430 agc 1419<210>292<211>432<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>292Met Ser Ser Thr Thr Leu Thr Asp Asp Gln Ile Arg Asp Asn Glu Arg 151015 Thr Glu Val Leu Ala Lys Ala Thr Ala Ala Lys Asn Ile Val Pro Asp

20 25 30Ile Ala Val Leu Gly Thr Gly Pro Lys Asn Ala Ile Leu Arg Ala Ala

35 40 45Ala Asp Glu Leu Val Ala Arg Ser Ala Glu Ile Ile Glu Ala Asn Ala

50 55 60Ser Asp Ile Glu Ala Gly Arg Ala Asn Gly Met Glu Glu Ser Met Ile 65 70 75 80Asp Arg Leu Ala Leu Asp Glu Ser Arg Ile Glu Gly Ile Ala Gly Gly

85 90 95Leu Arg Gln Val Ala Gly Leu Thr Asp Pro Val Gly Glu Val Leu Arg

100 105 110Gly His Val Met Glu Asn Gly Ile Gln Met Lys Gln Val Arg Val Pro

115 120 125Leu Gly Val Met Gly Met Val Tyr Glu Ala Arg Pro Asn Val Thr Val

130 135 140Asp Ala Phe Gly Leu Ala Leu Lys Ser Gly Asn Val Ala Leu Leu Arg145 150 155 160Gly Ser Ser Thr Ala Val His Ser Asn Thr Lys Leu Val Glu Ile Leu

165 170 175Gln Asp Val Leu Glu Arg Phe Glu Leu Pro Arg Glu Thr Val Gln Leu

180 185 190Leu Pro Cys Gln Thr Arg Gly Ser Val Gln Asp Leu Ile Thr Ala Arg

195 200 205Gly Leu Val Asp Val Val Ile Pro Arg Gly Gly Ala Gly Leu Ile Asn

210 215 220Ala Val Val Thr Gly Ala Thr Val Pro Thr Ile Glu Thr Gly Thr Gly225 230 235 240Asn Cys His Phe Tyr Ile Asp Ala Glu Ala Lys Leu Asp Gln Ala Ile

245 250 255Ala Met Val Ile Asn Gly Lys Thr Arg Arg Cys Ser Val Cys Asn Ala

260 265 270Thr Glu Thr Ala Leu Leu Asp Ala Ala Leu Ser Asp Ser Asp Lys Leu

275 280 285Ala Val Val Gln Ala Leu Gln Glu Ala Gly Val Thr Ile His Gly Arg

290 295 300Val Ala Glu Leu Glu Ala Phe Gly Ala Thr Asp Val Val Glu Ala Thr305 310 315 320Glu Thr Asp Trp Asp Ser Glu Tyr Leu Ser Phe Asp Ile Ala Val Ala

325 330 335Val Val Asp Gly Val Asp Gly Ala Leu Ala His Ile Ala Lys Tyr Ser

340 345 350Thr Lys His Thr Glu Ala Ile Ala Thr Gln Asn Ile Glu Thr Ala Gln

355 360 365Arg Phe Ala Asp Arg Val Asp Ala Ala Ala Val Met Ile Asn Ala Ser

370 375 380Thr Ala Tyr Thr Asp Gly Glu Gln Tyr Gly Met Gly Ala Glu Ile Gly385 390395 400Ile Ser Thr Gln Lys Leu His Ala Arg Gly Pro Met Ala Leu Pro Glu

405 410 415Leu Thr Ser Thr Lys Trp Ile Leu Gln Gly Thr Gly Gln Ile Arg Pro

420425430<210>293<211>724<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (709)<223>FRXA02378<400>293gagcagatgg ccaccgaggt cgatgtggtg gctggctact aggcctttta tggtgtgatc 60cgacactgtt gcttcttaag ggtctgtata gtgggcaacc atg agt tca acg acc 115

Met Ser Ser Thr Thr

1 5cta act gat gac caa att cgc gac aat gag cgg acc gaa gtt cta gct 163Leu Thr Asp Asp Gln Ile Arg Asp Asn Glu Arg Thr Glu Val Leu Ala

10 15 20aaa gca act gca gct aag aac atc gtc ccg gat att gca gtg ttg ggc 211Lys Ala Thr Ala Ala Lys Asn Ile Val Pro Asp Ile Ala Val Leu Gly

25 30 35acc gga ccg aag aac gca atc ctg cgt gcg gcg gca gat gaa ctc gtt 259Thr Gly Pro Lys Asn Ala Ile Leu Arg Ala Ala Ala Asp Glu Leu Val

40 45 50gca cgc agc gca gaa atc atc gaa gcc aac gct tcc gat atc gaa gcg 307Ala Arg Ser Ala Glu Ile Ile Glu Ala Asn Ala Ser Asp Ile Glu Ala

55 60 65ggt cgc gca aac ggc atg gaa gaa tcc atg att gat cgc ctt gcc ctt 355Gly Arg Ala Asn Gly Met Glu Glu Ser Met Ile Asp Arg Leu Ala Leu 70 75 80 85gat gaa tct cgc att gag ggc atc gct ggc ggt ttg cgc cag gtt gct 403Asp Glu Ser Arg Ile Glu Gly Ile Ala Gly Gly Leu Arg Gln Val Ala

90 95 100ggc ctg acc gac cca gtg ggt gaa gta ctg cgc gga cat gtc atg gaa 451Gly Leu Thr Asp Pro Val Gly Glu Val Leu Arg Gly His Val Met Glu

105 110 115aac ggc att cag atg aag cag gtc cgt gtg cct ttg ggc gtg atg ggc 499Asn Gly Ile Gln Met Lys Gln Val Arg Val Pro Leu Gly Val Met Gly

120 125 130atg gtc tat gaa gcc cgc cct aac gtc acc gtc gac gcc ttc ggc ctg 547Met Val Tyr Glu Ala Arg Pro Asn Val Thr Val Asp Ala Phe Gly Leu

135 140 145gca ctc aag tcc gga aac gta gct ttg ctg cgc ggt tcc tcc aca gct 595Ala Leu Lys Ser Gly Asn Val Ala Leu Leu Arg Gly Ser Ser Thr Ala150 155 160 165gtg cat tcc aac acc aag ctc gtg gaa atc ctg cag gac gta ctc gag 643Val His Ser Asn Thr Lys Leu Val Glu Ile Leu Gln Asp Val Leu Glu

170 175 180cgt ttc gag ctg cca cgc gaa acc gtg cag ttg ctg ctt gcc aaa ccc 691Arg Phe Glu Leu Pro Arg Glu Thr Val Gln Leu Leu Leu Ala Lys Pro

185 190 195gcg gat ccg tcc aag att tgatcaccgg acgcg 724Ala Asp Pro Ser Lys Ile

200<210>294<211>203<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>294Met Ser Ser Thr Thr Leu Thr Asp Asp Gln Ile Arg Asp Asn Glu Arg 151015 Thr Glu Val Leu Ala Lys Ala Thr Ala Ala Lys Asn Ile Val Pro Asp

20 25 30Ile Ala Val Leu Gly Thr Gly Pro Lys Asn Ala Ile Leu Arg Ala Ala

35 40 45Ala Asp Glu Leu Val Ala Arg Ser Ala Glu Ile Ile Glu Ala Asn Ala

50 55 60Ser Asp Ile Glu Ala Gly Arg Ala Asn Gly Met Glu Glu Ser Met Ile 65 70 75 80Asp Arg Leu Ala Leu Asp Glu Ser Arg Ile Glu Gly Ile Ala Gly Gly

85 90 95Leu Arg Gln Val Ala Gly Leu Thr Asp Pro Val Gly Glu Val Leu Arg

100 105 110Gly His Val Met Glu Asn Gly Ile Gln Met Lys Gln Val Arg Val Pro

115 120 125Leu Gly Val Met Gly Met Val Tyr Glu Ala Arg Pro Asn Val Thr Val

130 135 140Asp Ala Phe Gly Leu Ala Leu Lys Ser Gly Asn Val Ala Leu Leu Arg145 150 155 160Gly Ser Ser Thr Ala Val His Ser Asn Thr Lys Leu Val Glu Ile Leu

165 170 175Gln Asp Val Leu Glu Arg Phe Glu Leu Pro Arg Glu Thr Val Gln Leu

180 185 190Leu Leu Ala Lys Pro Ala Asp Pro Ser Lys Ile

195200<210>295<211>623<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (600)<223>FRXA02382<400>295ccc acc att gaa acc ggc acc ggc aac tgc cacttc tac atc gat gcc 48Pro Thr Ile Glu Thr Gly Thr Gly Asn Cys His Phe Tyr Ile Asp Ala 151015 gaa gcc aag ctt gat cag gca atc gcc atg gtc atc aac ggc aag acc 96Glu Ala Lys Leu Asp Gln Ala Ile Ala Met Val Ile Asn Gly Lys Thr

20 25 30cgc cgc tgc agc gtg tgc aac gct act gaa acc gcg ctt ctc gac gcc 144Arg Arg Cys Ser Val Cys Asn Ala Thr Glu Thr Ala Leu Leu Asp Ala

35 40 45gcc ctc agc gac tca gac aag ctt gca gtc gtc cag gcg ctc cag gaa 192Ala Leu Ser Asp Ser Asp Lys Leu Ala Val Val Gln Ala Leu Gln Glu

50 55 60gca gga gtc aca att cat gga cgg gtg gcc gaa ttg gaa gca ttc ggt 240Ala Gly Val Thr Ile His Gly Arg Val Ala Glu Leu Glu Ala Phe Gly 65 70 75 80gca acc gac gtg gtg gaa gca act gaa act gac tgg gat tct gag tac 288Ala Thr Asp Val Val Glu Ala Thr Glu Thr Asp Trp Asp Ser Glu Tyr

85 90 95ctg tcc ttc gat atc gct gtc gct gtg gtt gac ggt gtg gat gga gct 336Leu Ser Phe Asp Ile Ala Val Ala Val Val Asp Gly Val Asp Gly Ala

100 105 110ctg gca cac atc gct aag tac agc acc aag cac acc gaa gcg atc gcc 384Leu Ala His Ile Ala Lys Tyr Ser Thr Lys His Thr Glu Ala Ile Ala

115 120 125acc caa aac att gaa acc gct cag cgc ttt gca gat cgc gtc gat gca 432Thr Gln Asn Ile Glu Thr Ala Gln Arg Phe Ala Asp Arg Val Asp Ala

130 135 140gca gcg gtg atg ata aac gca tcc acc gcc tac acc gat ggg gag cag 480Ala Ala Val Met Ile Asn Ala Ser Thr Ala Tyr Thr Asp Gly Glu Gln145 150 155 160tac ggc atg ggc gcg gag atc ggc att tcc acc cag aaa ctg cat gca 528Tyr Gly Met Gly Ala Glu Ile Gly Ile Ser Thr Gln Lys Leu His Ala

165 170 175cgt gga cca atg gcc ctg cca gag ctg acc tcc acc aag tgg att ctg 576Arg Gly Pro Met Ala Leu Pro Glu Leu Thr Ser Thr Lys Trp Ile Leu

180 185 190cag ggc aca ggacaa att agg cct taagtttgaa gaagtaatca agc 623Gln Gly Thr Gly Gln Ile Arg Pro

195200<210>296<211>200<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>296Pro Thr Ile Glu Thr Gly Thr Gly Asn Cys His Phe Tyr Ile Asp Ala 151015 Glu Ala Lys Leu Asp Gln Ala Ile Ala Met Val Ile Asn Gly Lys Thr

20 25 30Arg Arg Cys Ser Val Cys Asn Ala Thr Glu Thr Ala Leu Leu Asp Ala

35 40 45Ala Leu Ser Asp Ser Asp Lys Leu Ala Val Val Gln Ala Leu Gln Glu

50 55 60Ala Gly Val Thr Ile His Gly Arg Val Ala Glu Leu Glu Ala Phe Gly 65 70 75 80Ala Thr Asp Val Val Glu Ala Thr Glu Thr Asp Trp Asp Ser Glu Tyr

85 90 95Leu Ser Phe Asp Ile Ala Val Ala Val Val Asp Gly Val Asp Gly Ala

100 105 110Leu Ala His Ile Ala Lys Tyr Ser Thr Lys His Thr Glu Ala Ile Ala

115 120 125Thr Gln Asn Ile Glu Thr Ala Gln Arg Phe Ala Asp Arg Val Asp Ala

130 135 140Ala Ala Val Met Ile Asn Ala Ser Thr Ala Tyr Thr Asp Gly Glu Gln145 150 155 160Tyr Gly Met Gly Ala Glu Ile Gly Ile Ser Thr Gln Lys Leu His Ala

165 170 175Arg Gly Pro Met Ala Leu Pro Glu Leu Thr Ser Thr Lys Trp Ile Leu

180 185 190Gln Gly Thr Gly Gln Ile Arg Pro

195200<210>297<211>933<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (910)<223>RXA02499<400>297cctggtcatg acgttcgggc cgctggcaat cgtcatgtaa tttgtcgttt tgggcccccg 60ctgctgcaaa acaggggtgg ttagtggcag tgtgggaacc atg aca aca att gct 115

Met Thr Thr Ile Ala

1 5gta atc ggc ggc gga caa atc ggc gag gct tta gtc tca ggt ttg atc 163Val Ile Gly Gly Gly Gln Ile Gly Glu Ala Leu Val Ser Gly Leu Ile

10 15 20gcg gcc aac atg aat cca caa aat att cgc gtc acc aac cgt tcg gaa 211Ala Ala Asn Met Asn Pro Gln Asn Ile Arg Val Thr Asn Arg Ser Glu

25 30 35gag cgc ggc caa gag ctg cgt gac cgc tac ggc atc ctc aac atg acg 259Glu Arg Gly Gln Glu Leu Arg Asp Arg Tyr Gly Ile Leu Asn Met Thr

40 45 50gat aat tcc caa gcc gca gac gaa gcc gac gtg gtg ttc ctg tgc gtg 307Asp Asn Ser Gln Ala Ala Asp Glu Ala Asp Val Val Phe Leu Cys Val

55 60 65aag ccg aaa ttt atc gtc gaa gtg ctc tcc gaa atc acc ggc act ttg 355Lys Pro Lys Phe Ile Val Glu Val Leu Ser Glu Ile Thr Gly Thr Leu 70 75 80 85gat aac aac tcc gca caa agt gtt gtg gtc agc atg gcc gca ggc atc 403Asp Asn Asn Ser Ala Gln Ser Val Val Val Ser Met Ala Ala Gly Ile

90 95 100agc atc gct gcc atg gaa gaa agc gcc tct gcg ggg ctc ccc gtc gtg 451Ser Ile Ala Ala Met Glu Glu Ser Ala Ser Ala Gly Leu Pro Val Val

105 110 115cgc gtc atg ccg aac act cca atg ctc gtg ggc aag ggc atg tcg act 499Arg Val Met Pro Asn Thr Pro Met Leu Val Gly Lys Gly Met Ser Thr

120 125 130gtc acc aaa ggc cgc tac gtt gac gcg gaa cag ttg gaa caa gtc aag 547Val Thr Lys Gly Arg Tyr Val Asp Ala Glu Gln Leu Glu Gln Val Lys

135 140 145gac ttg ttg agc acc gtt gga gac gtc ctc gaa gtc gcg gaa tca gac 595Asp Leu Leu Ser Thr Val Gly Asp Val Leu Glu Val Ala Glu Ser Asp150 155 160 165atc gac gca gtc acc gcg atg tcc gga tcc tcc cct gca tac ctg ttc 643Ile Asp Ala Val Thr Ala Met Ser Gly Ser Ser Pro Ala Tyr Leu Phe

170 175 180ctt gtg acc gaa gcg ctc att gag gca gga gtt aat cta ggc ctg ccc 691Leu Val Thr Glu Ala Leu Ile Glu Ala Gly Val Asn Leu Gly Leu Pro

185 190 195cgc gcg acc gct aaa aag ctc gct gtg gcc tca ttc gaa ggt gct gca 739Arg Ala Thr Ala Lys Lys Leu Ala Val Ala Ser Phe Glu Gly Ala Ala

200 205 210acc atg atg aag gaa acc ggc aaa gaa ccc tca gaa ttg cgc gca ggc 787Thr Met Met Lys Glu Thr Gly Lys Glu Pro Ser Glu Leu Arg Ala Gly

215 220 225gtt tcc tca ccc gca ggc acc acc gtc gca gcc atc cga gaa ctc gaa 835Val Ser Ser Pro Ala Gly Thr Thr Val Ala Ala Ile Arg Glu Leu Glu230 235 240 245gaa agc gga atc cga ggc gct ttc tac cgc gca gcc caa gct tgc gcc 883Glu Ser Gly Ile Arg Gly Ala Phe Tyr Arg Ala Ala Gln Ala Cys Ala

250 255 260gac cga tct gaa gaa ctc gga aag cgc tagaaaccgt tatttccccg 930Asp Arg Ser Glu Glu Leu Gly Lys Arg

265270 tta 933<210>298<211>270<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>298Met Thr Thr Ile Ala Val Ile Gly Gly Gly Gln Ile Gly Glu Ala Leu 151015 Val Ser Gly Leu Ile Ala Ala Asn Met Asn Pro Gln Asn Ile Arg Val

20 25 30Thr Asn Arg Ser Glu Glu Arg Gly Gln Glu Leu Arg Asp Arg Tyr Gly

35 40 45Ile Leu Asn Met Thr Asp Asn Ser Gln Ala Ala Asp Glu Ala Asp Val

50 55 60Val Phe Leu Cys Val Lys Pro Lys Phe Ile Val Glu Val Leu Ser Glu 65 70 75 80Ile Thr Gly Thr Leu Asp Asn Asn Ser Ala Gln Ser Val Val Val Ser

85 90 95Met Ala Ala Gly Ile Ser Ile Ala Ala Met Glu Glu Ser Ala Ser Ala

100 105 110Gly Leu Pro Val Val Arg Val Met Pro Asn Thr Pro Met Leu Val Gly

115 120 125Lys Gly Met Ser Thr Val Thr Lys Gly Arg Tyr Val Asp Ala Glu Gln

130 135 140Leu Glu Gln Val Lys Asp Leu Leu Ser Thr Val Gly Asp Val Leu Glu145 150 155 160Val Ala Glu Ser Asp Ile Asp Ala Val Thr Ala Met Ser Gly Ser Ser

165 170 175Pro Ala Tyr Leu Phe Leu Val Thr Glu Ala Leu Ile Glu Ala Gly Val

180 185 190Asn Leu Gly Leu Pro Arg Ala Thr Ala Lys Lys Leu Ala Val Ala Ser

195 200 205Phe Glu Gly Ala Ala Thr Met Met Lys Glu Thr Gly Lys GluPro Ser

210 215 220Glu Leu Arg Ala Gly Val Ser Ser Pro Ala Gly Thr Thr Val Ala Ala225 230 235 240Ile Arg Glu Leu Glu Glu Ser Gly Ile Arg Gly Ala Phe Tyr Arg Ala

245 250 255Ala Gln Ala Cys Ala Asp Arg Ser Glu Glu Leu Gly Lys Arg

260265270<210>299<211>1296<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1273)<223>RXS02157<400>299gggtggaatt ggcacgatgg tgctgccgga tgtttttgat cgggagaatt atcctgaagg 60caccgttttt agaaaagacg acaaggatgg ggaactgtaa atg agc acg ctg gaa 115

Met Ser Thr Leu Glu

1 5act tgg cca cag gtc att att aat acg tac ggc acc cca cca gtt gag 163Thr Trp Pro Gln Val Ile Ile Asn Thr Tyr Gly Thr Pro Pro Val Glu

10 15 20ctg gtg tcc ggc aag ggc gca acc gtc act gat gac cag ggc aat gtc 211Leu Val Ser Gly Lys Gly Ala Thr Val Thr Asp Asp Gln Gly Asn Val

25 30 35tac atc gac ttg ctc gcg ggc atc gca gtc aac gcg ttg ggc cac gcc 259Tyr Ile Asp Leu Leu Ala Gly Ile Ala Val Asn Ala Leu Gly His Ala

40 45 50cac ccg gcg atc atc gag gcg gtc acc aac cag atc ggc caa ctt ggt 307His Pro Ala Ile Ile Glu Ala Val Thr Asn Gln Ile Gly Gln Leu Gly

55 60 65cac gtc tca aac ttg ttc gca tcc agg ccc gtc gtc gag gtc gcc gag 355His Val Ser Asn Leu Phe Ala Ser Arg Pro Val Val Glu Val Ala Glu 7075 80 85gag ctc atc aag cgt ttt tcg ctt gac gac gcc acc ctc gcc gcg caa 403Glu Leu Ile Lys Arg Phe Ser Leu Asp Asp Ala Thr Leu Ala Ala Gln

90 95 100acc cgg gtt ttc ttc tgc aac tcg ggc gcc gaa gca aac gag gct gct 451Thr Arg Val Phe Phe Cys Asn Ser Gly Ala Glu Ala Asn Glu Ala Ala

105 110 115ttc aag att gca cgc ttg act ggt cgt tcc cgg att ctg gct gca gtt 499Phe Lys Ile Ala Arg Leu Thr Gly Arg Ser Arg Ile Leu Ala Ala Val

120 125 130cat ggt ttc cac ggc cgc acc atg ggt tcc ctc gcg ctg act ggc cag 547His Gly Phe His Gly Arg Thr Met Gly Ser Leu Ala Leu Thr Gly Gln

135 140 145cca gac aag cgt gaa gcg ttc ctg cca atg cca agc ggt gtg gag ttc 595Pro Asp Lys Arg Glu Ala Phe Leu Pro Met Pro Ser Gly Val Glu Phe150 155 160 165tac cct tac ggc gac acc gat tac ttg cgc aaa atg gta gaa acc aac 643Tyr Pro Tyr Gly Asp Thr Asp Tyr Leu Arg Lys Met Val Glu Thr Asn

170 175 180cca acg gat gtg gct gct atc ttc ctc gag cca atc cag ggt gaa acg 691Pro Thr Asp Val Ala Ala Ile Phe Leu Glu Pro Ile Gln Gly Glu Thr

185 190 195ggc gtt gtt cca gca cct gaa gga ttc ctc aag gca gtg cgc gag ctg 739Gly Val Val Pro Ala Pro Glu Gly Phe Leu Lys Ala Val Arg Glu Leu

200 205 210tgc gat gag tac ggc atc ttg atg atc acc gat gaa gtc cag act ggc 787Cys Asp Glu Tyr Gly Ile Leu Met Ile Thr Asp Glu Val Gln Thr Gly

215 220 225gtt ggc cgt acc ggc gat ttc ttt gca cat cag cac gat ggc gtt gtt 835Val Gly Arg Thr Gly Asp Phe Phe Ala His Gln His Asp Gly Val Val230 235 240 245ccc gat gtg gtg acc atg gcc aag gga ctt ggc ggc ggt ctt ccc atc 883Pro Asp Val Val Thr Met Ala Lys Gly Leu Gly Gly Gly Leu Pro Ile

250 255 260ggt gct tgt ttg gcc act ggc cgt gca gct gaa ttg atg acc cca ggc 931Gly Ala Cys Leu Ala Thr Gly Arg Ala Ala Glu Leu Met Thr Pro Gly

265 270 275aag cac ggc acc act ttc ggt ggc aac cca gtt gct tgt gca gct gcc 979Lys His Gly Thr Thr Phe Gly Gly Asn Pro Val Ala Cys Ala Ala Ala

280 285 290aag gca gtg ctg tct gtt gtc gat gac gct ttc tgc gca gaa gtt gcc 1027Lys Ala Val Leu Ser Val Val Asp Asp Ala Phe Cys Ala Glu Val Ala

295 300 305cgc aag ggc gag ctg ttc aag gaa ctt ctt gcc aag gtt gac ggc gtt 1075Arg Lys Gly Glu Leu Phe Lys Glu Leu Leu Ala Lys Val Asp Gly Val310 315 320 325gta gac gtc cgt ggc agg ggc ttg atg ttg ggc gtg gtg ctg gag cgc 1123Val Asp Val Arg Gly Arg Gly Leu Met Leu Gly Val Val Leu Glu Arg

330 335 340gac gtc gca aag caa gct gtt ctt gat ggt ttt aag cac ggc gtt att 1171Asp Val Ala Lys Gln Ala Val Leu Asp Gly Phe Lys His Gly Val Ile

345 350 355ttg aat gca ccg gcg gac aac att atc cgt ttg acc ccg ccg ctg gtg 1219Leu Asn Ala Pro Ala Asp Asn Ile Ile Arg Leu Thr Pro Pro Leu Val

360 365 370atc acc gac gaa gaa atc gca gac gca gtc aag gct att gcc gag aca 1267Ile Thr Asp Glu Glu Ile Ala Asp Ala Val Lys Ala Ile Ala Glu Thr

375380385 atc gca taaaggactc aaacttatga ctt 1296Ile Ala390<210>300<211>391<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>300Met Ser Thr Leu Glu Thr Trp Pro Gln Val Ile Ile Asn Thr Tyr Gly 151015 Thr Pro Pro Val Glu Leu Val Ser Gly Lys Gly Ala Thr Val Thr Asp

20 25 30Asp Gln Gly Asn Val Tyr Ile Asp Leu Leu Ala Gly Ile Ala Val Asn

35 40 45Ala Leu Gly His Ala His Pro Ala Ile Ile Glu Ala Val Thr Asn Gln

50 55 60Ile Gly Gln Leu Gly His Val Ser Asn Leu Phe Ala Ser Arg Pro Val 65 70 75 80Val Glu Val Ala Glu Glu Leu Ile Lys Arg Phe Ser Leu Asp Asp Ala

85 90 95Thr Leu Ala Ala Gln Thr Arg Val Phe Phe Cys Asn Ser Gly Ala Glu

100 105 110Ala Asn Glu Ala Ala Phe Lys Ile Ala Arg Leu Thr Gly Arg Ser Arg

115 120 125Ile Leu Ala Ala Val His Gly Phe His Gly Arg Thr Met Gly Ser Leu

130 135 140Ala Leu Thr Gly Gln Pro Asp Lys Arg Glu Ala Phe Leu Pro Met Pro145 150 155 160Ser Gly Val Glu Phe Tyr Pro Tyr Gly Asp Thr Asp Tyr Leu Arg Lys

165 170 175Met Val Glu Thr Asn Pro Thr Asp Val Ala Ala Ile Phe Leu Glu Pro

180 185 190Ile Gln Gly Glu Thr Gly Val Val Pro Ala Pro Glu Gly Phe Leu Lys

195 200 205Ala Val ArgGlu Leu Cys Asp Glu Tyr Gly Ile Leu Met Ile Thr Asp

210 215 220Glu Val Gln Thr Gly Val Gly Arg Thr Gly Asp Phe Phe Ala His Gln225 230 235 240His Asp Gly Val Val Pro Asp Val Val Thr Met Ala Lys Gly Leu Gly

245 250 255Gly Gly Leu Pro Ile Gly Ala Cys Leu Ala Thr Gly Arg Ala Ala Glu

260 265 270Leu Met Thr Pro Gly Lys His Gly Thr Thr Phe Gly Gly Asn Pro Val

275 280 285Ala Cys Ala Ala Ala Lys Ala Val Leu Ser Val Val Asp Asp Ala Phe

290 295 300Cys Ala Glu Val Ala Arg Lys Gly Glu Leu Phe Lys Glu Leu Leu Ala305 310 315 320Lys Val Asp Gly Val Val Asp Val Arg Gly Arg Gly Leu Met Leu Gly

325 330 335Val Val Leu Glu Arg Asp Val Ala Lys Gln Ala Val Leu Asp Gly Phe

340 345 350Lys His Gly Val Ile Leu Asn Ala Pro Ala Asp Asn Ile Ile Arg Leu

355 360 365Thr Pro Pro Leu Val Ile Thr Asp Glu Glu Ile Ala Asp Ala Val Lys

370375380 Ala Ile Ala Glu Thr Ile Ala 385390<210>301<211>1269<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1246)<223>RXS02262<400>301gcaccaattt cggacctgaa atccccgagg aaaccgtgcc cgacgccgtg caggtgggcg 60tcgataagca aaaaatcgct gatactcgaa aggcctcaaa atg acc gca acc tac 115

Met Thr Ala Thr Tyr

1 5acc act gaa acc gcc atc aat ttc ttg ttc ttg agc gaa ccg gac atg 163Thr Thr Glu Thr Ala Ile Asn Phe Leu Phe Leu Ser Glu Pro Asp Met

10 15 20atc gcg gcc gga gtc aaa gac gtc gcg caa tgc gtc gat gtc atg gag 211Ile Ala Ala Gly Val Lys Asp Val Ala Gln Cys Val Asp Val Met Glu

25 30 35gaa acg ctc gtg ctc ttg gcg cag ggc gac tac aaa atg gcc ggt ttg 259Glu Thr Leu Val Leu Leu Ala Gln Gly Asp Tyr Lys Met Ala Gly Leu

40 45 50aac tcc aac tcg cat ggc gcg atg atc acc ttc ccg gaa aac cca gaa 307Asn Ser Asn Ser His Gly Ala Met Ile Thr Phe Pro Glu Asn Pro Glu

55 60 65ttt gaa ggc atg ccc aag gac ggc ccc gac cgc cga ttc atg gcg atg 355Phe Glu Gly Met Pro Lys Asp Gly Pro Asp Arg Arg Phe Met Ala Met 70 75 80 85ccc gca tac ctc ggc ggg cga ttc aaa aac acc ggc gtg aag tgg tac 403Pro Ala Tyr Leu Gly Gly Arg Phe Lys Asn Thr Gly Val Lys Trp Tyr

90 95 100gga tcc aac gcg gaa aac aag gcc tca ggc ttg cct cgc tcg atc cac 451Gly Ser Asn Ala Glu Asn Lys Ala Ser Gly Leu Pro Arg Ser Ile His

105 110 115acc ttc gtc ctc aac gac acg gtc acc ggt gca ccg aag gcc atc atg 499Thr Phe Val Leu Asn Asp Thr Val Thr Gly Ala Pro Lys Ala Ile Met

120 125 130tcc gcg aac ctg ctg tcc gcc tac cgc acc ggc gcg gtt ccc ggc gtg 547Ser Ala Asn Leu Leu Ser Ala Tyr Arg Thr Gly Ala Val Pro Gly Val

135 140 145ggc gtg aag cac tta gcg gtc gcc gac gcg aca acc ttg gct gtc gtc 595Gly Val Lys His Leu Ala Val Ala Asp Ala Thr Thr Leu Ala Val Val150 155 160 165gga cct ggt gtc atg gcg aaa acc atc acc gaa gcg tgc atc gca gag 643Gly Pro Gly Val Met Ala Lys Thr Ile Thr Glu Ala Cys Ile Ala Glu

170 175 180cgc cca gga atc acc acc atc aag atc aag gga cgc agc gaa cgc ggc 691Arg Pro Gly Ile Thr Thr Ile Lys Ile Lys Gly Arg Ser Glu Arg Gly

185 190 195atc aac gcc ttt gca aca tgg gcg ttg gaa aaa ttc ccc gag atc gaa 739Ile Asn Ala Phe Ala Thr Trp Ala Leu Glu Lys Phe Pro Glu Ile Glu

200 205 210gtg gtc gcc gtc gga tct gaa gaa gac gtg gtc aaa gac gcc gac atc 787Val Val Ala Val Gly Ser Glu Glu Asp Val Val Lys Asp Ala Asp Ile

215 220 225gtc atc gcc gcc acc acc acg gac gcc gcc ggc tcc tcc gcc ttc cca 835Val Ile Ala Ala Thr Thr Thr Asp Ala Ala Gly Ser Ser Ala Phe Pro230 235 240 245tac ttc aaa aaa gaa tgg ctc aag ccg ggc gca ttg ctg ctg ctt cca 883Tyr Phe Lys Lys Glu Trp Leu Lys Pro Gly Ala Leu Leu Leu Leu Pro

250 255 260gcc gcc ggt cgc ttc gac gac gct tat ttg ctt gac gac gcc cgc ctc 931Ala Ala Gly Arg Phe Asp Asp Ala Tyr Leu Leu Asp Asp Ala Arg Leu

265 270 275gtt gtt gac tac atg ggg ctc tac gaa gcc tgg gca gaa gaa tac ggc 979Val Val Asp Tyr Met Gly Leu Tyr Glu Ala Trp Ala Glu Glu Tyr Gly

280 285 290cca cag gcc tac caa cta ctc ggc att cca gga acc cac tgg tac gac 1027Pro Gln Ala Tyr Gln Leu Leu Gly Ile Pro Gly Thr His Trp Tyr Asp

295 300 305ctg gcg ctg caa gga aaa ctc gac ctt gca aag att tcc cag att ggc 1075Leu Ala Leu Gln Gly Lys Leu Asp Leu Ala Lys Ile Ser Gln Ile Gly310 315 320 325gat atc tgc tcc ggc aag cta ccc gga cgc acc aac gat gag gaa atc 1123Asp Ile Cys Ser Gly Lys Leu Pro Gly Arg Thr Asn Asp Glu Glu Ile

330 335 340atc ctc tat tcc gtc ggc ggc atg cca gta gaa gac gtc gcc tgg gca 1171Ile Leu Tyr Ser Val Gly Gly Met Pro Val Glu Asp Val Ala Trp Ala

345 350 355acc caa gtg tat gaa aac gcc ctg gaa aaa ggc gtc ggc acc aca ttg 1219Thr Gln Val Tyr Glu Asn Ala Leu Glu Lys Gly Val Gly Thr Thr Leu

360 365 370aac ctg tgg gaa tca ccc gca ctg gct tgagagaaga aacaacaatg 1266Asn Leu Trp Glu Ser Pro Ala Leu Ala

375380 aaa 1269<210>302<211>382<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>302Met Thr Ala Thr Tyr Thr Thr Glu Thr Ala Ile Asn Phe Leu Phe Leu 151015 Ser Glu Pro Asp Met Ile Ala Ala Gly Val Lys Asp Val Ala Gln Cys

20 25 30Val Asp Val Met Glu Glu Thr Leu Val Leu Leu Ala Gln Gly Asp Tyr

35 40 45Lys Met Ala Gly Leu Asn Ser Asn Ser His Gly Ala Met Ile Thr Phe

50 55 60Pro Glu Asn Pro Glu Phe Glu Gly Met Pro Lys Asp Gly Pro Asp Arg65 70 75 80Arg Phe Met Ala Met Pro Ala Tyr Leu Gly Gly Arg Phe Lys Asn Thr

85 9095Gly Val Lys Trp Tyr Gly Ser Asn Ala Glu Asn Lys Ala Ser Gly Leu

100 105 110Pro Arg Ser Ile His Thr Phe Val Leu Asn Asp Thr Val Thr Gly Ala

115 120 125Pro Lys Ala Ile Met Ser Ala Asn Leu Leu Ser Ala Tyr Arg Thr Gly

130 135 140Ala Val Pro Gly Val Gly Val Lys His Leu Ala Val Ala Asp Ala Thr145 150 155 160Thr Leu Ala Val Val Gly Pro Gly Val Met Ala Lys Thr Ile Thr Glu

165 170 175Ala Cys Ile Ala Glu Arg Pro Gly Ile Thr Thr Ile Lys Ile Lys Gly

180 185 190Arg Ser Glu Arg Gly Ile Asn Ala Phe Ala Thr Trp Ala Leu Glu Lys

195 200 205Phe Pro Glu Ile Glu Val Val Ala Val Gly Ser Glu Glu Asp Val Val

210 215 220Lys Asp Ala Asp Ile Val Ile Ala Ala Thr Thr Thr Asp Ala Ala Gly225 230 235 240Ser Ser Ala Phe Pro Tyr Phe Lys Lys Glu Trp Leu Lys Pro Gly Ala

245 250 255Leu Leu Leu Leu Pro Ala Ala Gly Arg Phe Asp Asp Ala Tyr Leu Leu

260 265 270Asp Asp Ala Arg Leu Val Val Asp Tyr Met Gly Leu Tyr Glu Ala Trp

275 280 285Ala Glu Glu Tyr Gly Pro Gln Ala Tyr Gln Leu Leu Gly Ile Pro Gly

290 295 300Thr His Trp Tyr Asp Leu Ala Leu Gln Gly Lys Leu Asp Leu Ala Lys305 310 315 320Ile Ser Gln Ile Gly Asp Ile Cys Ser Gly Lys Leu Pro Gly Arg Thr

325 330 335Asn Asp Glu Glu Ile Ile Leu Tyr Ser Val Gly Gly Met Pro Val Glu

340 345 350Asp Val Ala Trp Ala Thr Gln Val Tyr Glu Asn Ala Leu Glu Lys Gly

355 360 365Val Gly Thr Thr Leu Asn Leu Trp Glu Ser Pro Ala Leu Ala

370375380<210>303<211>1491<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1468)<223>RXS02970<400>303aaccgacaaa acagccgttc acgtgctaaa gcagctcggc ttgatctagg gtgaggtgag 60ttatttaaag acttcataat attttgggga gtgaactggt ttg gca ttg aag ggt 115

Leu Ala Leu Lys Gly

1 5tac acc aac ttt gac ggt gaa ttc atc gaa ttc gga tct gtg caa gca 163Tyr Thr Asn Phe Asp Gly Glu Phe Ile Glu Phe Gly Ser Val Gln Ala

10 15 20aaa gaa gag gaa aaa cgg gca ttc gac aac gat cgc gcg cac gtt ttc 211Lys Glu Glu Glu Lys Arg Ala Phe Asp Asn Asp Arg Ala His Val Phe

25 30 35cac tcc tgg tcc gcg cag gac aaa atc agc ccc aaa gta tgg gca gct 259His Ser Trp Ser Ala Gln Asp Lys Ile Ser Pro Lys Val Trp Ala Ala

40 45 50gcc gaa ggt tcc acg ctg tac gac ttc gac ggc aac gcc ttc atc gac 307Ala Glu Gly Ser Thr Leu Tyr Asp Phe Asp Gly Asn Ala Phe Ile Asp

55 60 65atg ggt tcc caa ctt gtc tcg gca aac tta ggc cac aac aac cct cga 355Met Gly Ser Gln Leu Val Ser Ala Asn Leu Gly His Asn Asn Pro Arg 70 75 80 85tta gtt gag gcg atc cag cgc caa gca gcc cgg ttg acc aac atc aac 403Leu Val Glu Ala Ile Gln Arg Gln Ala Ala Arg Leu Thr Asn Ile Asn

90 95 100ccg gcc ttc ggc aat gat gtg cgc tct gat gtt gct gca aag atc gtg 451Pro Ala Phe Gly Asn Asp Val Arg Ser Asp Val Ala Ala Lys Ile Val

105 110 115tcg atg gcc cgt ggc gaa ttc tcc cac gtg ttt ttc acc aac ggc ggc 499Ser Met Ala Arg Gly Glu Phe Ser His Val Phe Phe Thr Asn Gly Gly

120 125 130gcc gac gcc atc gag cac tcc atc cgc atg gct cgc ctg cac acc gga 547Ala Asp Ala Ile Glu His Ser Ile Arg Met Ala Arg Leu His Thr Gly

135 140 145cgc aac aaa att ctg tcc gca tac cgc agc tac cac ggc gca acc gga 595Arg Asn Lys Ile Leu Ser Ala Tyr Arg Ser Tyr His Gly Ala Thr Gly150 155 160 165tcc gcg atg atg ctc acc ggc gaa cac cgc cgc ctg ggc aac ccc acc 643Ser Ala Met Met Leu Thr Gly Glu His Arg Arg Leu Gly Asn Pro Thr

170 175 180acc gac cca gat atc tac cac ttc tgg gca cca ttc ctg cac cac tcc 691Thr Asp Pro Asp Ile Tyr His Phe Trp Ala Pro Phe Leu His His Ser

185 190 195tca ttc ttt gcc acc acc caa gaa gaa gaa tgc gaa cgc gca ctc aag 739Ser Phe Phe Ala Thr Thr Gln Glu Glu Glu Cys Glu Arg Ala Leu Lys

200 205 210cac ttg gaa gat gtc atc gcg ttt gaa ggt gct ggc atg atc gca gcg 787His Leu Glu Asp Val Ile Ala Phe Glu Gly Ala Gly Met Ile Ala Ala

215 220 225atc gtc ctg gag cca gtg gtg gga tca tca gga atc atc ctg cca cca 835Ile Val Leu Glu Pro Val Val Gly Ser Ser Gly Ile Ile Leu Pro Pro230 235 240 245gca ggt tac tta aat ggc gtg cgc gaa ctt tgc aac aag cac ggc atc 883Ala Gly Tyr Leu Asn Gly Val Arg Glu Leu Cys Asn Lys His Gly Ile

250 255 260ctc ttc atc gcc gac gaa gtc atg gtc gga ttc gga cgc acc gga aaa 931Leu Phe Ile Ala Asp Glu Val Met Val Gly Phe Gly Arg Thr Gly Lys

265 270 275ctg ttt gct tac gag cat gct ggc gac gat ttc cag cca gac atg atc 979Leu Phe Ala Tyr Glu His Ala Gly Asp Asp Phe Gln Pro Asp Met Ile

280 285 290acc ttc gcc aag ggt gtt aac gca ggt tac gcc cca ctc ggt ggc atc 1027Thr Phe Ala Lys Gly Val Asn Ala Gly Tyr Ala Pro Leu Gly Gly Ile

295 300 305gtg atg acc caa tca atc cgc gat acc ttc gga tca gag gca tac tcc 1075Val Met Thr Gln Ser Ile Arg Asp Thr Phe Gly Ser Glu Ala Tyr Ser310 315 320 325ggc gga ctc acc tac tcc gga cac cca ctt gca gta gca ccc gcc aag 1123Gly Gly Leu Thr Tyr Ser Gly His Pro Leu Ala Val Ala Pro Ala Lys

330 335 340gca gcg ctg gag att tac gcg gaa gga gag atc att cca cgc gta gct 1171Ala Ala Leu Glu Ile Tyr Ala Glu Gly Glu Ile Ile Pro Arg Val Ala

345 350 355cga ctt ggc gct gaa ctg atc gaa cct cgc ctt cgt gaa cta gcg gaa 1219Arg Leu Gly Ala Glu Leu Ile Glu Pro Arg Leu Arg Glu Leu Ala Glu

360 365 370gaa aac gta gcg atc gct gac gtg cgg ggc atc gga ttc ttc tgg gca 1267Glu Asn Val Ala Ile Ala Asp Val Arg Gly Ile Gly Phe Phe Trp Ala

375 380 385gtg gag ttc aat gca gac gcc act gcc atg gct gcc ggt gct gca gaa 1315Val Glu Phe Asn Ala Asp Ala Thr Ala Met Ala Ala Gly Ala Ala Glu390 395 400 405ttc aag gaa cgc ggc gtg tgg ccg atg atc tcc ggc aac cga ttc cac 1363Phe Lys Glu Arg Gly Val Trp Pro Met Ile Ser Gly Asn Arg Phe His

410 415 420atc gcg ccg ccg ctg acc acc act gat gac gaa ttg gta gca ctg ctg 1411Ile Ala Pro Pro Leu Thr Thr Thr Asp Asp Glu Leu Val Ala Leu Leu

425 430 435gac gcg gtg gaa gct gca gcc caa gct gtc gag ctg acc ttc gct ggg 1459Asp Ala Val Glu Ala Ala Ala Gln Ala Val Glu Leu Thr Phe Ala Gly

440 445 450gcg ttg ttc taagttttct agataacaag gcc 1491Ala Leu Phe

455<210>304<211>456<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>304Leu Ala Leu Lys Gly Tyr Thr Asn Phe Asp Gly Glu Phe Ile Glu Phe 151015 Gly Ser Val Gln Ala Lys Glu Glu Glu Lys Arg Ala Phe Asp Asn Asp

20 25 30Arg Ala His Val Phe His Ser Trp Ser Ala Gln Asp Lys Ile Ser Pro

35 40 45Lys Val Trp Ala Ala Ala Glu Gly Ser Thr Leu Tyr Asp Phe Asp Gly

50 55 60Asn Ala Phe Ile Asp Met Gly Ser Gln Leu Val Ser Ala Asn Leu Gly 65 70 75 80His Asn Asn Pro Arg Leu Val Glu Ala Ile Gln Arg Gln Ala Ala Arg

85 90 95Leu Thr Asn Ile Asn Pro Ala Phe Gly AsnAsp Val Arg Ser Asp Val

100 105 110Ala Ala Lys Ile Val Ser Met Ala Arg Gly Glu Phe Ser His Val Phe

115 120 125Phe Thr Asn Gly Gly Ala Asp Ala Ile Glu His Ser Ile Arg Met Ala

130 135 140Arg Leu His Thr Gly Arg Asn Lys Ile Leu Ser Ala Tyr Arg Ser Tyr145 150 155 160His Gly Ala Thr Gly Ser Ala Met Met Leu Thr Gly Glu His Arg Arg

165 170 175Leu Gly Asn Pro Thr Thr Asp Pro Asp Ile Tyr His Phe Trp Ala Pro

180 185 190Phe Leu His His Ser Ser Phe Phe Ala Thr Thr Gln Glu Glu Glu Cys

195 200 205Glu Arg Ala Leu Lys His Leu Glu Asp Val Ile Ala Phe Glu Gly Ala

210 215 220Gly Met Ile Ala Ala Ile Val Leu Glu Pro Val Val Gly Ser Ser Gly225 230 235 240Ile Ile Leu Pro Pro Ala Gly Tyr Leu Asn Gly Val Arg Glu Leu Cys

245 250 255Asn Lys His Gly Ile Leu Phe Ile Ala Asp Glu Val Met Val Gly Phe

260 265 270Gly Arg Thr Gly Lys Leu Phe Ala Tyr Glu His Ala Gly Asp Asp Phe

275 280 285Gln Pro Asp Met Ile Thr Phe Ala Lys Gly Val Asn Ala Gly Tyr Ala

290 295 300Pro Leu Gly Gly Ile Val Met Thr Gln Ser Ile Arg Asp Thr Phe Gly305 310 315 320Ser Glu Ala Tyr Ser Gly Gly Leu Thr Tyr Ser Gly His Pro Leu Ala

325 330 335Val Ala Pro Ala Lys Ala Ala Leu Glu Ile Tyr Ala Glu Gly Glu Ile

340 345 350Ile Pro Arg Val Ala Arg Leu Gly Ala Glu Leu Ile Glu Pro Arg Leu

355 360 365Arg Glu Leu Ala Glu Glu Asn Val Ala Ile Ala Asp Val Arg Gly Ile

370 375 380Gly Phe Phe Trp Ala Val Glu Phe Asn Ala Asp Ala Thr Ala Met Ala385 390 395 400Ala Gly Ala Ala Glu Phe Lys Glu Arg Gly Val Trp Pro Met Ile Ser

405 410 415Gly Asn Arg Phe His Ile Ala Pro Pro Leu Thr Thr Thr Asp Asp Glu

420 425 430Leu Val Ala Leu Leu Asp Ala Val Glu Ala Ala Ala Gln Ala Val Glu

435 440 445Leu Thr Phe Ala Gly Ala Leu Phe

450455<210>305<211>1330<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1330)<223>FRXA01009<400>305aaccgacaaa acagccgttc acgtgctaaa gcagctcggc ttgatctagg gtgaggtgag 60ttatttaaag acttcataat attttgggga gtgaactggt ttg gca ttg aag ggt 115

Leu Ala Leu Lys Gly

1 5tac acc aac ttt gac ggt gaa ttc atc gaa ttc gga tct gtg caa gca 163Tyr Thr Asn Phe Asp Gly Glu Phe Ile Glu Phe Gly Ser Val Gln Ala

10 15 20aaa gaa gag gaa aaa cgg gca ttc gac aac gat cgc gcg cac gttttc 211Lys Glu Glu Glu Lys Arg Ala Phe Asp Asn Asp Arg Ala His Val Phe

25 30 35cac tcc tgg tcc gcg cag gac aaa atc agc ccc aaa gta tgg gca gct 259His Ser Trp Ser Ala Gln Asp Lys Ile Ser Pro Lys Val Trp Ala Ala

40 45 50gcc gaa ggt tcc acg ctg tac gac ttc gac ggc aac gcc ttc atc gac 307Ala Glu Gly Ser Thr Leu Tyr Asp Phe Asp Gly Asn Ala Phe Ile Asp

55 60 65atg ggt tcc caa ctt gtc tcg gca aac tta ggc cac aac aac cct cga 355Met Gly Ser Gln Leu Val Ser Ala Asn Leu Gly His Asn Asn Pro Arg 70 75 80 85tta gtt gag gcg atc cag cgc caa gca gcc cgg ttg acc aac atc aac 403Leu Val Glu Ala Ile Gln Arg Gln Ala Ala Arg Leu Thr Asn Ile Asn

90 95 100ccg gcc ttc ggc aat gat gtg cgc tct gat gtt gct gca aag atc gtg 451Pro Ala Phe Gly Asn Asp Val Arg Ser Asp Val Ala Ala Lys Ile Val

105 110 115tcg atg gcc cgt ggc gaa ttc tcc cac gtg ttt ttc acc aac ggc ggc 499Ser Met Ala Arg Gly Glu Phe Ser His Val Phe Phe Thr Asn Gly Gly

120 125 130gcc gac gcc atc gag cac tcc atc cgc atg gct cgc ctg cac acc gga 547Ala Asp Ala Ile Glu His Ser Ile Arg Met Ala Arg Leu His Thr Gly

135 140 145cgc aac aaa att ctg tcc gca tac cgc agc tac cac ggc gca acc gga 595Arg Asn Lys Ile Leu Ser Ala Tyr Arg Ser Tyr His Gly Ala Thr Gly150 155 160 165tcc gcg atg atg ctc acc ggc gaa cac cgc cgc ctg ggc aac ccc acc 643Ser Ala Met Met Leu Thr Gly Glu His Arg Arg Leu Gly Asn Pro Thr

170 175180acc gac cca gat atc tac cac ttc tgg gca cca ttc ctg cac cac tcc 691Thr Asp Pro Asp Ile Tyr His Phe Trp Ala Pro Phe Leu His His Ser

185 190 195tca ttc ttt gcc acc acc caa gaa gaa gaa tgc gaa cgc gca ctc aag 739Ser Phe Phe Ala Thr Thr Gln Glu Glu Glu Cys Glu Arg Ala Leu Lys

200 205 210cac ttg gaa gat gtc atc gcg ttt gaa ggt gct ggc atg atc gca gcg 787His Leu Glu Asp Val Ile Ala Phe Glu Gly Ala Gly Met Ile Ala Ala

215 220 225atc gtc ctg gag cca gtg gtg gga tca tca gga atc atc ctg cca cca 835Ile Val Leu Glu Pro Val Val Gly Ser Ser Gly Ile Ile Leu Pro Pro230 235 240 245gca ggt tac tta aat ggc gtg cgc gaa ctt tgc aac aag cac ggc atc 883Ala Gly Tyr Leu Asn Gly Val Arg Glu Leu Cys Asn Lys His Gly Ile

250 255 260ctc ttc atc gcc gac gaa gtc atg gtc gga ttc gga cgc acc gga aaa 931Leu Phe Ile Ala Asp Glu Val Met Val Gly Phe Gly Arg Thr Gly Lys

265 270 275ctg ttt gct tac gag cat gct ggc gac gat ttc cag cca gac atg atc 979Leu Phe Ala Tyr Glu His Ala Gly Asp Asp Phe Gln Pro Asp Met Ile

280 285 290acc ttc gcc aag ggt gtt aac gca ggt tac gcc cca ctc ggt ggc atc 1027Thr Phe Ala Lys Gly Val Asn Ala Gly Tyr Ala Pro Leu Gly Gly Ile

295 300 305gtg atg acc caa tca atc cgc gat acc ttc gga tca gag gca tac tcc 1075Val Met Thr Gln Ser Ile Arg Asp Thr Phe Gly Ser Glu Ala Tyr Ser310 315 320 325ggc gga ctc acc tac tcc gga cac cca ctt gca gta gca ccc gcc aag 1123Gly Gly Leu Thr Tyr Ser Gly HisPro Leu Ala Val Ala Pro Ala Lys

330 335 340gca gcg ctg gag att tac gcg gaa gga gag atc att cca cgc gta gct 1171Ala Ala Leu Glu Ile Tyr Ala Glu Gly Glu Ile Ile Pro Arg Val Ala

345 350 355cga ctt ggc gct gaa ctg atc gaa cct cgc ctt cgt gaa cta gcg gaa 1219Arg Leu Gly Ala Glu Leu Ile Glu Pro Arg Leu Arg Glu Leu Ala Glu

360 365 370gaa aac gta gcg atc gct gac gtg cgg ggc atc gga ttc ttc tgg gca 1267Glu Asn Val Ala Ile Ala Asp Val Arg Gly Ile Gly Phe Phe Trp Ala

375 380 385gtg gag ttc aat gca gac gcc act gcc atg gct gcc ggt gct gca gaa 1315Val Glu Phe Asn Ala Asp Ala Thr Ala Met Ala Ala Gly Ala Ala Glu390 395 400 405ttc aag gaa cgc ggc 1330Phe Lys Glu Arg Gly

410<210>306<211>410<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>306Leu Ala Leu Lys Gly Tyr Thr Asn Phe Asp Gly Glu Phe Ile Glu Phe 151015 Gly Ser Val Gln Ala Lys Glu Glu Glu Lys Arg Ala Phe Asp Asn Asp

20 25 30Arg Ala His Val Phe His Ser Trp Ser Ala Gln Asp Lys Ile Ser Pro

35 40 45Lys Val Trp Ala Ala Ala Glu Gly Ser Thr Leu Tyr Asp Phe Asp Gly

50 55 60Asn Ala Phe Ile Asp Met Gly Ser Gln Leu Val Ser Ala Asn Leu Gly 65 70 75 80His Asn Asn Pro Arg Leu Val Glu Ala Ile Gln Arg Gln Ala Ala Arg

85 90 95Leu Thr Asn Ile Asn Pro Ala Phe Gly Asn Asp Val Arg Ser Asp Val

100 105 110Ala Ala Lys Ile Val Ser Met Ala Arg Gly Glu Phe Ser His Val Phe

115 120 125Phe Thr Asn Gly Gly Ala Asp Ala Ile Glu His Ser Ile Arg Met Ala

130 135 140Arg Leu His Thr Gly Arg Asn Lys Ile Leu Ser Ala Tyr Arg Ser Tyr145 150 155 160His Gly Ala Thr Gly Ser Ala Met Met Leu Thr Gly Glu His Arg Arg

165 170 175Leu Gly Asn Pro Thr Thr Asp Pro Asp Ile Tyr His Phe Trp Ala Pro

180 185 190Phe Leu His His Ser Ser Phe Phe Ala Thr Thr Gln Glu Glu Glu Cys

195 200 205Glu Arg Ala Leu Lys His Leu Glu Asp Val Ile Ala Phe Glu Gly Ala

210 215 220Gly Met Ile Ala Ala Ile Val Leu Glu Pro Val Val Gly Ser Ser Gly225 230 235 240Ile Ile Leu Pro Pro Ala Gly Tyr Leu Asn Gly Val Arg Glu Leu Cys

245 250 255Asn Lys His Gly Ile Leu Phe Ile Ala Asp Glu Val Met Val Gly Phe

260 265 270Gly Arg Thr Gly Lys Leu Phe Ala Tyr Glu His Ala Gly Asp Asp Phe

275 280 285Gln Pro Asp Met Ile Thr Phe Ala Lys Gly Val Asn Ala Gly Tyr Ala

290 295 300Pro Leu Gly Gly Ile Val Met Thr Gln Ser Ile Arg Asp Thr Phe Gly305 310 315 320Ser Glu Ala Tyr Ser Gly Gly Leu ThrTyr Ser Gly His Pro Leu Ala

325 330 335Val Ala Pro Ala Lys Ala Ala Leu Glu Ile Tyr Ala Glu Gly Glu Ile

340 345 350Ile Pro Arg Val Ala Arg Leu Gly Ala Glu Leu Ile Glu Pro Arg Leu

355 360 365Arg Glu Leu Ala Glu Glu Asn Val Ala Ile Ala Asp Val Arg Gly Ile

370 375 380Gly Phe Phe Trp Ala Val Glu Phe Asn Ala Asp Ala Thr Ala Met Ala385 390 395 400Ala Gly Ala Ala Glu Phe Lys Glu Arg Gly

405410<210>307<211>3579<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (3556)<223>RXN00023<400>307gggattatgt tgggggccac atctgaaaat agttgctggg atccatcaca cctacgatgc 60gaaacggcac ccacaccgct gatcttgaag gagaaccacc atg acg tcg atg aat 115

Met Thr Ser Met Asn

1 5ctg cct att gag ttg gct acg ctg tct gac cag gct gtg gac aag gtg 163Leu Pro Ile Glu Leu Ala Thr Leu Ser Asp Gln Ala Val Asp Lys Val

10 15 20cgc tcc tgg ctg gag tac agc aaa aag gaa agc gtg ccc aat gcc gat 211Arg Ser Trp Leu Glu Tyr Ser Lys Lys Glu Ser Val Pro Asn Ala Asp

25 30 35gcg aag cgt cta gct gca gtg ttg cag gat cct aat ggt ttg gaa ttc 259Ala Lys Arg Leu Ala Ala Val Leu Gln Asp Pro Asn Gly Leu Glu Phe

40 45 50acg gtt ggt ttc gtg gat cga gtg gtt cga act gag gat cgt gaa gcg 307Thr Val Gly Phe Val Asp Arg Val Val Arg Thr Glu Asp Arg Glu Ala

55 60 65gca gcg cat gcg ttg tat gag ttg ggc aag att gct ccg tcg acg atg 355Ala Ala His Ala Leu Tyr Glu Leu Gly Lys Ile Ala Pro Ser Thr Met 70 75 80 85tcc ttt ttg gat cgg gcg cag att cag gcc ggt tct ttg gtg ggg cgg 403Ser Phe Leu Asp Arg Ala Gln Ile Gln Ala Gly Ser Leu Val Gly Arg

90 95 100gcg ttg ccg cag gtt gtg gtt cct gcg gcg cgg gct cga atc cgg cag 451Ala Leu Pro Gln Val Val Val Pro Ala Ala Arg Ala Arg Ile Arg Gln

105 110 115atg gtt ggg cac atg att gtg gat gcc cgc gac aag cag ttc gcc aag 499Met Val Gly His Met Ile Val Asp Ala Arg Asp Lys Gln Phe Ala Lys

120 125 130gct gtc gct gag att cag tcg gat ggg cac cgc ctg aac atc aat ttg 547Ala Val Ala Glu Ile Gln Ser Asp Gly His Arg Leu Asn Ile Asn Leu

135 140 145cta ggt gaa gcg gtg ttg ggc cga aag gag gca gcg aag cat ttg gat 595Leu Gly Glu Ala Val Leu Gly Arg Lys Glu Ala Ala Lys His Leu Asp150 155 160 165gac acg gtg cgg ttg ttg cgc cgt ccg gat gtg gaa tat gtg tcc atc 643Asp Thr Val Arg Leu Leu Arg Arg Pro Asp Val Glu Tyr Val Ser Ile

170 175 180aag gtc tct tcg gtg gca tcg cag att tcg atg tgg ggt ttc gaa gac 691Lys Val Ser Ser Val Ala Ser Gln Ile Ser Met Trp Gly Phe Glu Asp

185 190 195acc gtt aat tat gtt gtg gaa cag ctg aca cct tta tat ata gag gcc 739Thr Val Asn Tyr Val Val Glu Gln Leu Thr Pro Leu Tyr Ile Glu Ala

200205 210gcg cgg gcg ccg aaa ggc acg aag ttc atc aac ctg gac atg gag gaa 787Ala Arg Ala Pro Lys Gly Thr Lys Phe Ile Asn Leu Asp Met Glu Glu

215 220 225tac cgc gat ctg cgc ctg act atg gag gtg ttc aag cgg ctg ctc tcc 835Tyr Arg Asp Leu Arg Leu Thr Met Glu Val Phe Lys Arg Leu Leu Ser230 235 240 245aat cca gag ctg cat gaa cta gaa gcc gga att gtg ttg cag gcg tac 883Asn Pro Glu Leu His Glu Leu Glu Ala Gly Ile Val Leu Gln Ala Tyr

250 255 260ctt ccc gat gcc ctc ggt gca atc cag gac ttg gcg cag ttc ggc cgc 931Leu Pro Asp Ala Leu Gly Ala Ile Gln Asp Leu Ala Gln Phe Gly Arg

265 270 275gag cgc gtc aac aca ggc ggg gcg ggc gtt aag gtt cgc ctg gtc aag 979Glu Arg Val Asn Thr Gly Gly Ala Gly Val Lys Val Arg Leu Val Lys

280 285 290ggt gct aat ttg cct atg gag cac gtc cac gcg cag atc acc ggc tgg 1027Gly Ala Asn Leu Pro Met Glu His Val His Ala Gln Ile Thr Gly Trp

295 300 305cca gtt gcc aca gaa cct tcc aaa caa gcc acc gat gcc aat tac aag 1075Pro Val Ala Thr Glu Pro Ser Lys Gln Ala Thr Asp Ala Asn Tyr Lys310 315 320 325cgc gtc ctc tat tgg acg atg cgc aaa gaa aac atg gag ggc ctg cgc 1123Arg Val Leu Tyr Trp Thr Met Arg Lys Glu Asn Met Glu Gly Leu Arg

330 335 340ctg ggc gtt gcc ggc cac aac ctt ttc gac ata gca ttc gca cat ttg 1171Leu Gly Val Ala Gly His Asn Leu Phe Asp Ile Ala Phe Ala His Leu

345 350 355ctc tct gtg gag cgt ggg gta gcg gac cgt gtg gag ttc gaa atg ctg 1219Leu Ser Val Glu Arg Gly Val Ala Asp Arg Val Glu Phe Glu Met Leu

360 365 370cag ggc atg gcg tcc gat cag gcg cgc gcc gtc agc gtt gac gtc ggt 1267Gln Gly Met Ala Ser Asp Gln Ala Arg Ala Val Ser Val Asp Val Gly

375 380 385gag ctg ctg ctt tac gta cca gcc gtg cgc cca caa gaa ttc gac gtg 1315Glu Leu Leu Leu Tyr Val Pro Ala Val Arg Pro Gln Glu Phe Asp Val390 395 400 405gcc att tct tac ctc gtg cgc cgc ctc gag gaa aac gcc gcg agc gaa 1363Ala Ile Ser Tyr Leu Val Arg Arg Leu Glu Glu Asn Ala Ala Ser Glu

410 415 420aac ttc atg tcc gcc atc ttc gac ctc gac gcc gac aac ccg tcc ttc 1411Asn Phe Met Ser Ala Ile Phe Asp Leu Asp Ala Asp Asn Pro Ser Phe

425 430 435aag cga gag gag agc cgc ttc cgc gcc tcc ata tct gac ctc gcc acg 1459Lys Arg Glu Glu Ser Arg Phe Arg Ala Ser Ile Ser Asp Leu Ala Thr

440 445 450ctc atc gac gtg ccc gcg ccc ggc ccc aac cac aca caa gac cgc agc 1507Leu Ile Asp Val Pro Ala Pro Gly Pro Asn His Thr Gln Asp Arg Ser

455 460 465aaa gag acg ctt ctc gac gcc ccc ctc gtc cca ttt atc aac gag ccc 1555Lys Glu Thr Leu Leu Asp Ala Pro Leu Val Pro Phe Ile Asn Glu Pro470 475 480 485gac acc aac cca gcg ctc atc caa aac caa cag tgg gcc aca aaa gcc 1603Asp Thr Asn Pro Ala Leu Ile Gln Asn Gln Gln Trp Ala Thr Lys Ala

490 495 500gtc gcc acc gca gca gag ccc ggt tgg ttg gaa aaa caa aca aag ccg 1651Val Ala Thr Ala Ala Glu Pro Gly Trp Leu Glu Lys Gln Thr Lys Pro

505510 515gag gtg ttg gaa gag ggg gac gtc gac aag cta att aac gat gtg cgc 1699Glu Val Leu Glu Glu Gly Asp Val Asp Lys Leu Ile Asn Asp Val Arg

520 525 530gac gct gct gaa gcg tgg gca gcg cgc cca gcc cgt gaa cgc gct gag 1747Asp Ala Ala Glu Ala Trp Ala Ala Arg Pro Ala Arg Glu Arg Ala Glu

535 540 545att ttg tac aag acc gcc gag att ttg cgc gtg cga cgc gga cac ctg 1795Ile Leu Tyr Lys Thr Ala Glu Ile Leu Arg Val Arg Arg Gly His Leu550 555 560 565atc tca gtg acg gcc gcg gag gtg ggc aaa gct gtg gaa caa acc gac 1843Ile Ser Val Thr Ala Ala Glu Val Gly Lys Ala Val Glu Gln Thr Asp

570 575 580ccg gaa atc tct gaa gcc att gat ttc gcc cgc tac tac gcg cat ttg 1891Pro Glu Ile Ser Glu Ala Ile Asp Phe Ala Arg Tyr Tyr Ala His Leu

585 590 595gcc ctg gaa ttg gac gac gta gac aat gcg gaa ttc acc cca gat cgc 1939Ala Leu Glu Leu Asp Asp Val Asp Asn Ala Glu Phe Thr Pro Asp Arg

600 605 610gtc gtt gtg gtg acc ccg ccc tgg aat ttc ccc atc gcg atc ccc gct 1987Val Val Val Val Thr Pro Pro Trp Asn Phe Pro Ile Ala Ile Pro Ala

615 620 625gga tcg act ttc gca gca ctc gcg gcg ggc gct ggc gtg atc cac aaa 2035Gly Ser Thr Phe Ala Ala Leu Ala Ala Gly Ala Gly Val Ile His Lys630 635 640 645ccc tca aag cct agc caa cat tgc tcc gct gca gtg gtc gaa gcc ctc 2083Pro Ser Lys Pro Ser Gln His Cys Ser Ala Ala Val Val Glu Ala Leu

650 655 660tgg gaa gcc ggc gtt ccc cgc gag gtt ctg cat tgc att tac cca gct 2131TrpGlu Ala Gly Val Pro Arg Glu Val Leu His Cys Ile Tyr Pro Ala

665 670 675aat cgc gat gtt gga tgt gcg ttg atc agc cat gaa cac gtc gac cgc 2179Asn Arg Asp Val Gly Cys Ala Leu Ile Ser His Glu His Val Asp Arg

680 685 690gtc att ttg acc ggc tcc tcc gag acc gcc gcg atg ttc tcc tcc tgg 2227Val Ile Leu Thr Gly Ser Ser Glu Thr Ala Ala Met Phe Ser Ser Trp

695 700 705cga cca gaa ctc acc atc aac ggc gaa acc tcc ggc aaa aac gcc atc 2275Arg Pro Glu Leu Thr Ile Asn Gly Glu Thr Ser Gly Lys Asn Ala Ile710 715 720 725gtg gtc acc cca tct gcc gac cgc gac ctc gcc gtc gcc gac ctg gtg 2323Val Val Thr Pro Ser Ala Asp Arg Asp Leu Ala Val Ala Asp Leu Val

730 735 740aaa tcc gcc ttc ggc cat gca gga caa aaa tgt tcc gca gcc tcc ctc 2371Lys Ser Ala Phe Gly His Ala Gly Gln Lys Cys Ser Ala Ala Ser Leu

745 750 755ggc atc ttg gta ggc agc gtc tac gaa tca gaa cgc ttc cgg aaa cag 2419Gly Ile Leu Val Gly Ser Val Tyr Glu Ser Glu Arg Phe Arg Lys Gln

760 765 770ctg gta gac gcc gca tcc tca ctc atc gtc gac tgg cct acc aac ccc 2467Leu Val Asp Ala Ala Ser Ser Leu Ile Val Asp Trp Pro Thr Asn Pro

775 780 785tcc gca acc gtc gga cca ctc acc gaa ctc ccc agc gat aaa ctc cac 2515Ser Ala Thr Val Gly Pro Leu Thr Glu Leu Pro Ser Asp Lys Leu His790 795 800 805cac gcc cta acc acc ctc gaa gaa gga gaa agc tgg ctg ctg aaa ccc 2563His Ala Leu Thr Thr Leu Glu Glu Gly Glu Ser Trp Leu Leu Lys Pro

810815 820cga caa ctc gac gac acc ggc cga ctc tgg tca ccc ggc atc aaa gaa 2611Arg Gln Leu Asp Asp Thr Gly Arg Leu Trp Ser Pro Gly Ile Lys Glu

825 830 835ggc gtc aaa cca gga acc ttc ttc cac ctc aca gaa gta ttc gga cca 2659Gly Val Lys Pro Gly Thr Phe Phe His Leu Thr Glu Val Phe Gly Pro

840 845 850gtc ctc ggc ctg atg aaa gcc acc gac ctc aat gaa gcc atc gaa ttc 2707Val Leu Gly Leu Met Lys Ala Thr Asp Leu Asn Glu Ala Ile Glu Phe

855 860 865caa aac ggc aac gac ttc gga ctc acc ggc gga ctc caa tcc ctc gac 2755Gln Asn Gly Asn Asp Phe Gly Leu Thr Gly Gly Leu Gln Ser Leu Asp870 875 880 885gcc gac gaa gtc cgc acc tgg ctt gac cac gtc gat gtc gga aac gcc 2803Ala Asp Glu Val Arg Thr Trp Leu Asp His Val Asp Val Gly Asn Ala

890 895 900tac gtc aac cgc ggc atc acc ggc gcc att gtc caa cgc caa tcc ttc 2851Tyr Val Asn Arg Gly Ile Thr Gly Ala Ile Val Gln Arg Gln Ser Phe

905 910 915gga ggc tgg aaa aaa tcc tcc gtc ggc ctc gga tcc aaa gcc gga gga 2899Gly Gly Trp Lys Lys Ser Ser Val Gly Leu Gly Ser Lys Ala Gly Gly

920 925 930ccc aac tat gtc atg ctc atg gga acc tgg gcc gac gcg cca agc cac 2947Pro Asn Tyr Val Met Leu Met Gly Thr Trp Ala Asp Ala Pro Ser His

935 940 945cac gcc cca cgc gaa aca aac ccg ctg atc agc aaa ctg gat ctc ccc 2995His Ala Pro Arg Glu Thr Asn Pro Leu Ile Ser Lys Leu Asp Leu Pro950 955 960 965gga gaa gag ctc gaa tgg ctc gaa aaa gcc aac gcc agc gat gaa aca 3043Gly Glu Glu Leu Glu Trp Leu Glu Lys Ala Asn Ala Ser Asp Glu Thr

970 975 980gca tgg aac acg gaa ttc ggc agc cca cgc gac ccc tcc ggc ctc gat 3091Ala Trp Asn Thr Glu Phe Gly Ser Pro Arg Asp Pro Ser Gly Leu Asp

985 990 995gta gaa gcc aac att ttc cgc tac cga cca gca gag gta gta ctc cga 3139Val Glu Ala Asn Ile Phe Arg Tyr Arg Pro Ala Glu Val Val Leu Arg

1000 1005 1010ctc gac gat tcc gcc aca ccc cga gaa act gcc cgc gca ttg ttg gca 3187Leu Asp Asp Ser Ala Thr Pro Arg Glu Thr Ala Arg Ala Leu Leu Ala

1015 1020 1025gcc cgt cgc gcc ggg gtt act ccg cga gtt ctt caa aca cca ggt gtt 3235Ala Arg Arg Ala Gly Val Thr Pro Arg Val Leu Gln Thr Pro Gly Val1030 1035 1040 1045tca gag caa gtc cgc gaa gta ttg tcc gct gct gga gtg agt gca gaa 3283Ser Glu Gln Val Arg Glu Val Leu Ser Ala Ala Gly Val Ser Ala Glu

1050 1055 1060aca gtc gat gat tcg gta ttt att tcc aac gtg ttg cgc ggc gaa tac 3331Thr Val Asp Asp Ser Val Phe Ile Ser Asn Val Leu Arg Gly Glu Tyr

1065 1070 1075gac gag aac tcc agc gtc cga gtc cgc tac ctg ggc aaa gtt agc gac 3379Asp Glu Asn Ser Ser Val Arg Val Arg Tyr Leu Gly Lys Val Ser Asp

1080 1085 1090act gtc cgt gaa cgc cta tct gta cgg ccc gaa gtt gtt ctg ctt gac 3427Thr Val Arg Glu Arg Leu Ser Val Arg Pro Glu Val Val Leu Leu Asp

1095 1100 1105gat gca gta act gcc tcc ggt cga gtt gaa tta cgt tac tgg ctc aaa 3475Asp Ala Val Thr Ala Ser Gly Arg Val Glu Leu Arg Tyr Trp Leu Lys1110 11151120 1125gaa caa gca att tcc atg acg ttg cac cgt ttt gga aac cca gtt gcg 3523Glu Gln Ala Ile Ser Met Thr Leu His Arg Phe Gly Asn Pro Val Ala

1130 1135 1140gcc ttc cac gag ttg gcg gag gaa ctt aaa cgt tgatcgtttt gcgcatgggt 3576Ala Phe His Glu Leu Ala Glu Glu Leu Lys Arg

11451150 cgc 3579<210>308<211>1152<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>308Met Thr Ser Met Asn Leu Pro Ile Glu Leu Ala Thr Leu Ser Asp Gln 151015 Ala Val Asp Lys Val Arg Ser Trp Leu Glu Tyr Ser Lys Lys Glu Ser

20 25 30Val Pro Asn Ala Asp Ala Lys Arg Leu Ala Ala Val Leu Gln Asp Pro

35 40 45Asn Gly Leu Glu Phe Thr Val Gly Phe Val Asp Arg Val Val Arg Thr

50 55 60Glu Asp Arg Glu Ala Ala Ala His Ala Leu Tyr Glu Leu Gly Lys Ile 65 70 75 80Ala Pro Ser Thr Met Ser Phe Leu Asp Arg Ala Gln Ile Gln Ala Gly

85 90 95Ser Leu Val Gly Arg Ala Leu Pro Gln Val Val Val Pro Ala Ala Arg

100 105 110Ala Arg Ile Arg Gln Met Val Gly His Met Ile Val Asp Ala Arg Asp

115 120 125Lys Gln Phe Ala Lys Ala Val Ala Glu Ile Gln Ser Asp Gly His Arg

130 135 140Leu Asn Ile Asn Leu Leu Gly Glu Ala Val Leu Gly Arg Lys Glu Ala145 150 155 160Ala Lys His Leu Asp Asp Thr Val Arg Leu Leu Arg Arg Pro Asp Val

165 170 175Glu Tyr Val Ser Ile Lys Val Ser Ser Val Ala Ser Gln Ile Ser Met

180 185 190Trp Gly Phe Glu Asp Thr Val Asn Tyr Val Val Glu Gln Leu Thr Pro

195 200 205Leu Tyr Ile Glu Ala Ala Arg Ala Pro Lys Gly Thr Lys Phe Ile Asn

210 215 220Leu Asp Met Glu Glu Tyr Arg Asp Leu Arg Leu Thr Met Glu Val Phe225 230 235 240Lys Arg Leu Leu Ser Asn Pro Glu Leu His Glu Leu Glu Ala Gly Ile

245 250 255Val Leu Gln Ala Tyr Leu Pro Asp Ala Leu Gly Ala Ile Gln Asp Leu

260 265 270Ala Gln Phe Gly Arg Glu Arg Val Asn Thr Gly Gly Ala Gly Val Lys

275 280 285Val Arg Leu Val Lys Gly Ala Asn Leu Pro Met Glu His Val His Ala

290 295 300Gln Ile Thr Gly Trp Pro Val Ala Thr Glu Pro Ser Lys Gln Ala Thr305 310 315 320Asp Ala Asn Tyr Lys Arg Val Leu Tyr Trp Thr Met Arg Lys Glu Asn

325 330 335Met Glu Gly Leu Arg Leu Gly Val Ala Gly His Asn Leu Phe Asp Ile

340 345 350Ala Phe Ala His Leu Leu Ser Val Glu Arg Gly Val Ala Asp Arg Val

355 360 365Glu Phe Glu Met Leu Gln Gly Met Ala Ser Asp Gln Ala Arg Ala Val

370 375 380Ser Val Asp Val Gly Glu Leu Leu Leu Tyr Val Pro Ala Val Arg Pro385 390395 400Gln Glu Phe Asp Val Ala Ile Ser Tyr Leu Val Arg Arg Leu Glu Glu

405 410 415Asn Ala Ala Ser Glu Asn Phe Met Ser Ala Ile Phe Asp Leu Asp Ala

420 425 430Asp Asn Pro Ser Phe Lys Arg Glu Glu Ser Arg Phe Arg Ala Ser Ile

435 440 445Ser Asp Leu Ala Thr Leu Ile Asp Val Pro Ala Pro Gly Pro Asn His

450 455 460Thr Gln Asp Arg Ser Lys Glu Thr Leu Leu Asp Ala Pro Leu Val Pro465 470 475 480Phe Ile Asn Glu Pro Asp Thr Asn Pro Ala Leu Ile Gln Asn Gln Gln

485 490 495Trp Ala Thr Lys Ala Val Ala Thr Ala Ala Glu Pro Gly Trp Leu Glu

500 505 510Lys Gln Thr Lys Pro Glu Val Leu Glu Glu Gly Asp Val Asp Lys Leu

515 520 525Ile Asn Asp Val Arg Asp Ala Ala Glu Ala Trp Ala Ala Arg Pro Ala

530 535 540Arg Glu Arg Ala Glu Ile Leu Tyr Lys Thr Ala Glu Ile Leu Arg Val545 550 555 560Arg Arg Gly His Leu Ile Ser Val Thr Ala Ala Glu Val Gly Lys Ala

565 570 575Val Glu Gln Thr Asp Pro Glu Ile Ser Glu Ala Ile Asp Phe Ala Arg

580 585 590Tyr Tyr Ala His Leu Ala Leu Glu Leu Asp Asp Val Asp Asn Ala Glu

595 600 605Phe Thr Pro Asp Arg Val Val Val Val Thr Pro Pro Trp Asn Phe Pro

610 615 620Ile Ala Ile Pro Ala Gly Ser Thr Phe Ala Ala Leu Ala Ala Gly Ala625 630 635 640Gly Val Ile His Lys Pro Ser Lys Pro Ser Gln His Cys Ser Ala Ala

645 650 655Val Val Glu Ala Leu Trp Glu Ala Gly Val Pro Arg Glu Val Leu His

660 665 670Cys Ile Tyr Pro Ala Asn Arg Asp Val Gly Cys Ala Leu Ile Ser His

675 680 685Glu His Val Asp Arg Val Ile Leu Thr Gly Ser Ser Glu Thr Ala Ala

690 695 700Met Phe Ser Ser Trp Arg Pro Glu Leu Thr Ile Asn Gly Glu Thr Ser705 710 715 720Gly Lys Asn Ala Ile Val Val Thr Pro Ser Ala Asp Arg Asp Leu Ala

725 730 735Val Ala Asp Leu Val Lys Ser Ala Phe Gly His Ala Gly Gln Lys Cys

740 745 750Ser Ala Ala Ser Leu Gly Ile Leu Val Gly Ser Val Tyr Glu Ser Glu

755 760 765Arg Phe Arg Lys Gln Leu Val Asp Ala Ala Ser Ser Leu Ile Val Asp

770 775 780Trp Pro Thr Asn Pro Ser Ala Thr Val Gly Pro Leu Thr Glu Leu Pro785 790 795 800Ser Asp Lys Leu His His Ala Leu Thr Thr Leu Glu Glu Gly Glu Ser

805 810 815Trp Leu Leu Lys Pro Arg Gln Leu Asp Asp Thr Gly Arg Leu Trp Ser

820 825 830Pro Gly Ile Lys Glu Gly Val Lys Pro Gly Thr Phe Phe His Leu Thr

835 840845Glu Val Phe Gly Pro Val Leu Gly Leu Met Lys Ala Thr Asp Leu Asn

850 855 860Glu Ala Ile Glu Phe Gln Asn Gly Asn Asp Phe Gly Leu Thr Gly Gly865 870 875 880Leu Gln Ser Leu Asp Ala Asp Glu Val Arg Thr Trp Leu Asp His Val

885 890 895Asp Val Gly Asn Ala Tyr Val Asn Arg Gly Ile Thr Gly Ala Ile Val

900 905 910Gln Arg Gln Ser Phe Gly Gly Trp Lys Lys Ser Ser Val Gly Leu Gly

915 920 925Ser Lys Ala Gly Gly Pro Asn Tyr Val Met Leu Met Gly Thr Trp Ala

930 935 940Asp Ala Pro Ser His His Ala Pro Arg Glu Thr Asn Pro Leu Ile Ser945 950 955 960Lys Leu Asp Leu Pro Gly Glu Glu Leu Glu Trp Leu Glu Lys Ala Asn

965 970 975Ala Ser Asp Glu Thr Ala Trp Asn Thr Glu Phe Gly Ser Pro Arg Asp

980 985 990Pro Ser Gly Leu Asp Val Glu Ala Asn Ile Phe Arg Tyr Arg Pro Ala

995 1000 1005Glu Val Val Leu Arg Leu Asp Asp Ser Ala Thr Pro Arg Glu Thr Ala

1010 1015 1020Arg Ala Leu Leu Ala Ala Arg Arg Ala Gly Val Thr Pro Arg Val Leu1025 1030 1035 1040Gln Thr Pro Gly Val Ser Glu Gln Val Arg Glu Val Leu Ser Ala Ala

1045 1050 1055Gly Val Ser Ala Glu Thr Val Asp Asp Ser Val Phe Ile Ser Asn Val

1060 1065 1070LeuArg Gly Glu Tyr Asp Glu Asn Ser Ser Val Arg Val Arg Tyr Leu

1075 1080 1085Gly Lys Val Ser Asp Thr Val Arg Glu Arg Leu Ser Val Arg Pro Glu

1090 1095 1100Val Val Leu Leu Asp Asp Ala Val Thr Ala Ser Gly Arg Val Glu Leu1105 1110 1115 1120Arg Tyr Trp Leu Lys Glu Gln Ala Ile Ser Met Thr Leu His Arg Phe

1125 1130 1135Gly Asn Pro Val Ala Ala Phe His Glu Leu Ala Glu Glu Leu Lys Arg

114011451150<210>309<211>476<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (453)<223>FRXA00023<400>309cat ttt ccg ctc cga cca gca gag gta gta ctc cga ctc gac gat tcc 48His Phe Pro Leu Arg Pro Ala Glu Val Val Leu Arg Leu Asp Asp Ser 151015 gcc aca ccc cga gaa act gcc cgc gca ttg ttg gca gcc cgt cgc gcc 96Ala Thr Pro Arg Glu Thr Ala Arg Ala Leu Leu Ala Ala Arg Arg Ala

20 25 30ggg gtt act ccg cga gtt ctt caa aca cca ggt gtt tca gag caa gtc 144Gly Val Thr Pro Arg Val Leu Gln Thr Pro Gly Val Ser Glu Gln Val

35 40 45cgc gaa gta ttg tcc gct gct gga gtg agt gca gaa aca gtc gat gat 192Arg Glu Val Leu Ser Ala Ala Gly Val Ser Ala Glu Thr Val Asp Asp

50 55 60tcg gta ttt att tcc aac gtg ttg cgc ggc gaa tac gac gag aac tcc 240Ser Val Phe Ile Ser Asn Val Leu Arg Gly Glu Tyr Asp Glu Asn Ser 65 70 75 80agc gtc cga gtc cgc tac ctg ggc aaa gtt agc gac act gtc cgt gaa 288Ser Val Arg Val Arg Tyr Leu Gly Lys Val Ser Asp Thr Val Arg Glu

85 90 95cgc cta tct gta cgg ccc gaa gtt gtt ctg ctt gac gat gca gta act 336Arg Leu Ser Val Arg Pro Glu Val Val Leu Leu Asp Asp Ala Val Thr

100 105 110gcc tcc ggt cga gtt gaa tta cgt tac tgg ctc aaa gaa caa gca att 384Ala Ser Gly Arg Val Glu Leu Arg Tyr Trp Leu Lys Glu Gln Ala Ile

115 120 125tcc atg acg ttg cac cgt ttt gga aac cca gtt gcg gcc ttc cac gag 432Ser Met Thr Leu His Arg Phe Gly Asn Pro Val Ala Ala Phe His Glu

130135140 ttg gcg gag gaa ctt aaa cgt tgatcgtttt gcgcatgggt cgc 476Leu Ala Glu Glu Leu Lys Arg 145150<210>310<211>151<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>310His Phe Pro Leu Arg Pro Ala Glu Val Val Leu Arg Leu Asp Asp Ser 151015 Ala Thr Pro Arg Glu Thr Ala Arg Ala Leu Leu Ala Ala Arg Arg Ala

20 25 30Gly Val Thr Pro Arg Val Leu Gln Thr Pro Gly Val Ser Glu Gln Val

35 40 45Arg Glu Val Leu Ser Ala Ala Gly Val Ser Ala Glu Thr Val Asp Asp

50 55 60Ser Val Phe Ile Ser Asn Val Leu Arg Gly Glu Tyr Asp Glu Asn Ser 65 70 75 80Ser Val Arg Val Arg Tyr Leu Gly Lys Val Ser Asp Thr Val Arg Glu

85 90 95Arg Leu Ser Val Arg Pro Glu Val Val Leu Leu Asp Asp Ala Val Thr

100 105 110Ala Ser Gly Arg Val Glu Leu Arg Tyr Trp Leu Lys Glu Gln Ala Ile

115 120 125Ser Met Thr Leu His Arg Phe Gly Asn Pro Val Ala Ala Phe His Glu

130135140 Leu Ala Glu Glu Leu Lys Arg 145150<210>311<211>3124<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (3124)<223>FRXA02284<220><221>misc _ feature<222>641-647<223>n ═ a, c, g, or t<220><221>VARIANT<222>181, 182<223>Xaa ═ any amino acid<220><221>VARIANT<222>183>Xaa Phe, Ser, Tyr, or Cys<400>311gggattatgt tgggggccac atctgaaaat agttgctggg atccatcaca cctacgatgc 60gaaacggcac ccacaccgct gatcttgaag gagaaccacc atg acg tcg atg aat 115

Met Thr Ser Met Asn

1 5ctg cct att gag ttg gct acg ctg tct gac cag gct gtg gac aag gtg 163Leu Pro Ile Glu Leu Ala Thr Leu Ser Asp Gln Ala Val Asp Lys Val

10 15 20cgc tcc tgg ctg gag tac agc aaa aag gaa agc gtg ccc aat gcc gat 211Arg Ser Trp Leu Glu Tyr Ser Lys Lys Glu Ser Val Pro Asn Ala Asp

25 30 35gcg aag cgt cta gct gca gtg ttg cag gat cct aat ggt ttg gaa ttc 259Ala Lys Arg Leu Ala Ala Val Leu Gln Asp Pro Asn Gly Leu Glu Phe

40 45 50acg gtt ggt ttc gtg gat cga gtg gtt cga act gag gat cgt gaa gcg 307Thr Val Gly Phe Val Asp Arg Val Val Arg Thr Glu Asp Arg Glu Ala

55 60 65gca gcg cat gcg ttg tat gag ttg ggc aag att gct ccg tcg acg atg 355Ala Ala His Ala Leu Tyr Glu Leu Gly Lys Ile Ala Pro Ser Thr Met 70 75 80 85tcc ttt ttg gat cgg gcg cag att cag gcc ggt tct ttg gtg ggg cgg403Ser Phe Leu Asp Arg Ala Gln Ile Gln Ala Gly Ser Leu Val Gly Arg

90 95 100gcg ttg ccg cag gtt gtg gtt cct gcg gcg cgg gct cga atc cgg cag 451Ala Leu Pro Gln Val Val Val Pro Ala Ala Arg Ala Arg Ile Arg Gln

105 110 115atg gtt ggg cac atg att gtg gat gcc cgc gac aag cag ttc gcc aag 499Met Val Gly His Met Ile Val Asp Ala Arg Asp Lys Gln Phe Ala Lys

120 125 130gct gtc gct gag att cag tcg gat ggg cac cgc ctg aac atc aat ttg 547Ala Val Ala Glu Ile Gln Ser Asp Gly His Arg Leu Asn Ile Asn Leu

135 140 145cta ggt gaa gcg gtg ttg ggc cga aag gaa gca gcg aag cat ttg gat 595Leu Gly Glu Ala Val Leu Gly Arg Lys Glu Ala Ala Lys His Leu Asp150 155 160 165gac acg gtg cgg ttg ttg cgc cgt ccg gat gtg gaa tat gtg tcn nnn 643Asp Thr Val Arg Leu Leu Arg Arg Pro Asp Val Glu Tyr Val Ser Xaa

170 175 180nnn ntc tct tcg gtg gca tcg cag att tcg atg tgg ggt ttc gaa gac 691Xaa Xaa Ser Ser Val Ala Ser Gln Ile Ser Met Trp Gly Phe Glu Asp

185 190 195acc gtt aat tat gtt gtg gaa cag ctg aca cct tta tat ata gag ccc 739Thr Val Asn Tyr Val Val Glu Gln Leu Thr Pro Leu Tyr Ile Glu Pro

200 205 210gcg cgg gcg ccg aaa ggc acg aag ttc atc aac ctg gac atg gag gaa 787Ala Arg Ala Pro Lys Gly Thr Lys Phe Ile Asn Leu Asp Met Glu Glu

215 220 225tac cgc gat ctg cgc ctg act atg gag gtg ttc aag cgg ctg ctc tcc 835Tyr Arg Asp Leu Arg Leu Thr Met Glu Val Phe Lys Arg Leu Leu Ser230 235240 245aat cca gag ctg cat gaa cta gaa gcc gga att gtg ttg cag gcg tac 883Asn Pro Glu Leu His Glu Leu Glu Ala Gly Ile Val Leu Gln Ala Tyr

250 255 260ctt ccc gat gcc ctc ggt gca atc cag gac ttg gcg cag ttc ggc cgc 931Leu Pro Asp Ala Leu Gly Ala Ile Gln Asp Leu Ala Gln Phe Gly Arg

265 270 275gag cgc gtc aac aca ggc ggg gcg ggc gtt aag gtt cgc ctg gtc aag 979Glu Arg Val Asn Thr Gly Gly Ala Gly Val Lys Val Arg Leu Val Lys

280 285 290ggt gct aat ttg cct atg gag cac gtc cac gcg cag atc acc ggc tgg 1027Gly Ala Asn Leu Pro Met Glu His Val His Ala Gln Ile Thr Gly Trp

295 300 305cca gtt gcc aca gaa cct tcc aaa caa gcc acc gat gcc aat tac aag 1075Pro Val Ala Thr Glu Pro Ser Lys Gln Ala Thr Asp Ala Asn Tyr Lys310 315 320 325cgc gtc ctc tat tgg acg atg cgc aaa gaa aac atg gag ggc ctg cgc 1123Arg Val Leu Tyr Trp Thr Met Arg Lys Glu Asn Met Glu Gly Leu Arg

330 335 340ctg ggc gtt gcc ggc cac aac ctt ttc gac ata gca ttc gca cat ttg 1171Leu Gly Val Ala Gly His Asn Leu Phe Asp Ile Ala Phe Ala His Leu

345 350 355ctc tct gtg gag cgt ggg gta gcg gac cgt gtg gag ttc gaa atg ctg 1219Leu Ser Val Glu Arg Gly Val Ala Asp Arg Val Glu Phe Glu Met Leu

360 365 370cag ggc atg gcg tcc gat cag gcg cgc gcc gtc agc gtt gac gtc ggt 1267Gln Gly Met Ala Ser Asp Gln Ala Arg Ala Val Ser Val Asp Val Gly

375 380 385gag ctg ctg ctt tac gta cca gcc gtg cgc cca caagaa ttc gac gtg 1315Glu Leu Leu Leu Tyr Val Pro Ala Val Arg Pro Gln Glu Phe Asp Val390 395 400 405gcc att tct tac ctc gtg cgc cgc ctc gag gaa aac gcc gcg agc gaa 1363Ala Ile Ser Tyr Leu Val Arg Arg Leu Glu Glu Asn Ala Ala Ser Glu

410 415 420aac ttc atg tcc gcc atc ttc gac ctc gac gcc gac aac ccg tcc ttc 1411Asn Phe Met Ser Ala Ile Phe Asp Leu Asp Ala Asp Asn Pro Ser Phe

425 430 435aag cga gag gag agc cgc ttc cgc gcc tcc ata tct gac ctc gcc acg 1459Lys Arg Glu Glu Ser Arg Phe Arg Ala Ser Ile Ser Asp Leu Ala Thr

440 445 450ctc atc gac gtg ccc gcg ccc ggc ccc aac cac aca caa gac cgc agc 1507Leu Ile Asp Val Pro Ala Pro Gly Pro Asn His Thr Gln Asp Arg Ser

455 460 465aaa gag acg ctt ctc gac gcc ccc ctc gtc cca ttt atc aac gag ccc 1555Lys Glu Thr Leu Leu Asp Ala Pro Leu Val Pro Phe Ile Asn Glu Pro470 475 480 485gac acc aac cca gcg ctc atc caa aac caa cag tgg gcc aca aaa gcc 1603Asp Thr Asn Pro Ala Leu Ile Gln Asn Gln Gln Trp Ala Thr Lys Ala

490 495 500gtc gcc acc gca gca gag ccc ggt tgg ttg gaa aaa caa aca aag ccg 1651Val Ala Thr Ala Ala Glu Pro Gly Trp Leu Glu Lys Gln Thr Lys Pro

505 510 515gag gtg ttg gaa gag ggg gac gtc gac aag cta att aac gat gtg cgc 1699Glu Val Leu Glu Glu Gly Asp Val Asp Lys Leu Ile Asn Asp Val Arg

520 525 530gac gct gct gaa gcg tgg gca gcg cgc cca gcc cgt gaa cgc gct gag 1747Asp Ala Ala Glu Ala Trp Ala Ala Arg Pro Ala Arg Glu Arg Ala Glu

535 540 545att ttg tac aag acc gcc gag att ttg cgc gtg cga cgc gga cac ctg 1795Ile Leu Tyr Lys Thr Ala Glu Ile Leu Arg Val Arg Arg Gly His Leu550 555 560 565atc tca gtg acg gcc gcg gag gtg ggc aaa gct gtg gaa caa acc gac 1843Ile Ser Val Thr Ala Ala Glu Val Gly Lys Ala Val Glu Gln Thr Asp

570 575 580ccg gaa atc tct gaa gcc att gat ttc gcc cgc tac tac gcg cat ttg 1891Pro Glu Ile Ser Glu Ala Ile Asp Phe Ala Arg Tyr Tyr Ala His Leu

585 590 595gcc ctg gaa ttg gac gac gta gac aat gcg gaa ttc acc cca gat cgc 1939Ala Leu Glu Leu Asp Asp Val Asp Asn Ala Glu Phe Thr Pro Asp Arg

600 605 610gtc gtt gtg gtg acc ccg ccc tgg aat ttc ccc atc gcg atc ccc gct 1987Val Val Val Val Thr Pro Pro Trp Asn Phe Pro Ile Ala Ile Pro Ala

615 620 625gga tcg act ttc gca gca ctc gcg gcg ggc gct ggc gtg atc cac aaa 2035Gly Ser Thr Phe Ala Ala Leu Ala Ala Gly Ala Gly Val Ile His Lys630 635 640 645ccc tca aag cct agc caa cat tgc tcc gct gca gtg gtc gaa gcc ctc 2083Pro Ser Lys Pro Ser Gln His Cys Ser Ala Ala Val Val Glu Ala Leu

650 655 660tgg gaa gcc ggc gtt ccc cgc gag gtt ctg cat tgc att tac cca gct 2131Trp Glu Ala Gly Val Pro Arg Glu Val Leu His Cys Ile Tyr Pro Ala

665 670 675aat cgc gat gtt gga tgt gcg ttg atc agc cat gaa cac gtc gac cgc 2179Asn Arg Asp Val Gly Cys Ala Leu Ile Ser His Glu His Val Asp Arg

680 685 690gtc att ttg acc ggc tcc tcc gag acc gcc gcg atg ttc tcc tcctgg 2227Val Ile Leu Thr Gly Ser Ser Glu Thr Ala Ala Met Phe Ser Ser Trp

695 700 705cga cca gaa ctc acc atc aac ggc gaa acc tcc ggc aaa aac gcc atc 2275Arg Pro Glu Leu Thr Ile Asn Gly Glu Thr Ser Gly Lys Asn Ala Ile710 715 720 725gtg gtc acc cca tct gcc gac cgc gac ctc gcc gtc gcc gac ctg gtg 2323Val Val Thr Pro Ser Ala Asp Arg Asp Leu Ala Val Ala Asp Leu Val

730 735 740aaa tcc gcc ttc ggc cat gca gga caa aaa tgt tcc gca gcc tcc ctc 2371Lys Ser Ala Phe Gly His Ala Gly Gln Lys Cys Ser Ala Ala Ser Leu

745 750 755ggc atc ttg gta ggc agc gtc tac gaa tca gaa cgc ttc cgg aaa cag 2419Gly Ile Leu Val Gly Ser Val Tyr Glu Ser Glu Arg Phe Arg Lys Gln

760 765 770ctg gta gac gcc gca tcc tca ctc atc gtc gac tgg cct acc aac ccc 2467Leu Val Asp Ala Ala Ser Ser Leu Ile Val Asp Trp Pro Thr Asn Pro

775 780 785tcc gca acc gtc gga cca ctc acc gaa ctc ccc agc gat aaa ctc cac 2515Ser Ala Thr Val Gly Pro Leu Thr Glu Leu Pro Ser Asp Lys Leu His790 795 800 805cac gcc cta acc acc ctc gaa gaa gga gaa agc tgg ctg ctg aaa ccc 2563His Ala Leu Thr Thr Leu Glu Glu Gly Glu Ser Trp Leu Leu Lys Pro

810 815 820cga caa ctc gac gac acc ggc cga ctc tgg tca ccc ggc atc aaa gaa 2611Arg Gln Leu Asp Asp Thr Gly Arg Leu Trp Ser Pro Gly Ile Lys Glu

825 830 835ggc gtc aaa cca gga acc ttc ttc cac ctc aca gaa gta ttc gga cca 2659Gly Val Lys Pro Gly Thr Phe Phe His Leu Thr Glu Val Phe Gly Pro

840 845 850gtc ctc ggc ctg atg aaa gcc acc gac ctc aat gaa gcc atc gaa ttc 2707Val Leu Gly Leu Met Lys Ala Thr Asp Leu Asn Glu Ala Ile Glu Phe

855 860 865caa aac ggc aac gac ttc gga ctc acc ggc gga ctc caa tcc ctc gac 2755Gln Asn Gly Asn Asp Phe Gly Leu Thr Gly Gly Leu Gln Ser Leu Asp870 875 880 885gcc gac gaa gtc cgc acc tgg ctt gac cac gtc gat gtc gga aac gcc 2803Ala Asp Glu Val Arg Thr Trp Leu Asp His Val Asp Val Gly Asn Ala

890 895 900tac gtc aac cgc ggc atc acc ggc gcc att gtc caa cgc caa tcc ttc 2851Tyr Val Asn Arg Gly Ile Thr Gly Ala Ile Val Gln Arg Gln Ser Phe

905 910 915gga ggc tgg aaa aaa tcc tcc gtc ggc ctc gga tcc aaa gcc gga gga 2899Gly Gly Trp Lys Lys Ser Ser Val Gly Leu Gly Ser Lys Ala Gly Gly

920 925 930ccc aac tat gtc atg ctc atg gga acc tgg gcc gac gcg cca agc cac 2947Pro Asn Tyr Val Met Leu Met Gly Thr Trp Ala Asp Ala Pro Ser His

935 940 945cac gcc cca cgc gaa aca aac ccg ctg atc agc aaa ctg gat ctc ccc 2995His Ala Pro Arg Glu Thr Asn Pro Leu Ile Ser Lys Leu Asp Leu Pro950 955 960 965gga gaa gag ctc gaa tgg ctc gaa aaa gcc aac gcc agc gat gaa aca 3043Gly Glu Glu Leu Glu Trp Leu Glu Lys Ala Asn Ala Ser Asp Glu Thr

970 975 980gca tgg aac acg gaa ttc ggc agc cca cgc gac ccc tcc ggc ctc gat 3091Ala Trp Asn Thr Glu Phe Gly Ser Pro Arg Asp Pro Ser Gly Leu Asp

985 990 995gta gaa gcc aac att ttc cgc tac cga cca gca3124Val Glu Ala Asn Ile Phe Arg Tyr Arg Pro Ala

10001005<210>312<211>1008<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>VARIANT<222>181, 182<223>Xaa ═ and amino acid<220><221>VARIANT<222>183<223>Xaa ═ Phe, Ser, Tyr, or Cys<400>312Met Thr Ser Met Asn Leu Pro Ile Glu Leu Ala Thr Leu Ser Asp Gln 151015 Ala Val Asp Lys Val Arg Ser Trp Leu Glu Tyr Ser Lys Lys Glu Ser

20 25 30Val Pro Asn Ala Asp Ala Lys Arg Leu Ala Ala Val Leu Gln Asp Pro

35 40 45Asn Gly Leu Glu Phe Thr Val Gly Phe Val Asp Arg Val Val Arg Thr

50 55 60Glu Asp Arg Glu Ala Ala Ala His Ala Leu Tyr Glu Leu Gly Lys Ile 65 70 75 80Ala Pro Ser Thr Met Ser Phe Leu Asp Arg Ala Gln Ile Gln Ala Gly

85 90 95Ser Leu Val Gly Arg Ala Leu Pro Gln Val Val Val Pro Ala Ala Arg

100 105 110Ala Arg Ile Arg Gln Met Val Gly His Met Ile Val Asp Ala Arg Asp

115 120 125Lys Gln Phe Ala Lys Ala Val Ala Glu Ile Gln Ser Asp Gly His Arg

130 135 140Leu Asn Ile Asn Leu Leu Gly Glu Ala Val Leu Gly Arg Lys Glu Ala145 150 155 160Ala Lys His Leu Asp Asp Thr Val Arg Leu Leu Arg Arg Pro Asp Val

165 170 175Glu Tyr Val Ser Xaa Xaa Xaa Ser Ser Val Ala Ser Gln Ile Ser Met

180 185 190Trp Gly Phe Glu Asp Thr Val Asn Tyr Val Val Glu Gln Leu Thr Pro

195 200 205Leu Tyr Ile Glu Pro Ala Arg Ala Pro Lys Gly Thr Lys Phe Ile Asn

210 215 220Leu Asp Met Glu Glu Tyr Arg Asp Leu Arg Leu Thr Met Glu Val Phe225 230 235 240Lys Arg Leu Leu Ser Asn Pro Glu Leu His Glu Leu Glu Ala Gly Ile

245 250 255Val Leu Gln Ala Tyr Leu Pro Asp Ala Leu Gly Ala Ile Gln Asp Leu

260 265 270Ala Gln Phe Gly Arg Glu Arg Val Asn Thr Gly Gly Ala Gly Val Lys

275 280 285Val Arg Leu Val Lys Gly Ala Asn Leu Pro Met Glu His Val His Ala

290 295 300Gln Ile Thr Gly Trp Pro Val Ala Thr Glu Pro Ser Lys Gln Ala Thr305 310 315 320Asp Ala Asn Tyr Lys Arg Val Leu Tyr Trp Thr Met Arg Lys Glu Asn

325 330 335Met Glu Gly Leu Arg Leu Gly Val Ala Gly His Asn Leu Phe Asp Ile

340 345 350Ala Phe Ala His Leu Leu Ser Val Glu Arg Gly Val Ala Asp Arg Val

355 360 365Glu Phe Glu Met Leu Gln Gly Met Ala Ser Asp Gln Ala Arg Ala Val

370 375 380Ser Val Asp Val Gly Glu Leu Leu Leu Tyr Val Pro Ala Val Arg Pro385 390 395 400Gln Glu Phe Asp Val Ala Ile Ser Tyr Leu Val Arg Arg Leu Glu Glu

405410 415Asn Ala Ala Ser Glu Asn Phe Met Ser Ala Ile Phe Asp Leu Asp Ala

420 425 430Asp Asn Pro Ser Phe Lys Arg Glu Glu Ser Arg Phe Arg Ala Ser Ile

435 440 445Ser Asp Leu Ala Thr Leu Ile Asp Val Pro Ala Pro Gly Pro Asn His

450 455 460Thr Gln Asp Arg Ser Lys Glu Thr Leu Leu Asp Ala Pro Leu Val Pro465 470 475 480Phe Ile Asn Glu Pro Asp Thr Asn Pro Ala Leu Ile Gln Asn Gln Gln

485 490 495Trp Ala Thr Lys Ala Val Ala Thr Ala Ala Glu Pro Gly Trp Leu Glu

500 505 510Lys Gln Thr Lys Pro Glu Val Leu Glu Glu Gly Asp Val Asp Lys Leu

515 520 525Ile Asn Asp Val Arg Asp Ala Ala Glu Ala Trp Ala Ala Arg Pro Ala

530 535 540Arg Glu Arg Ala Glu Ile Leu Tyr Lys Thr Ala Glu Ile Leu Arg Val545 550 555 560Arg Arg Gly His Leu Ile Ser Val Thr Ala Ala Glu Val Gly Lys Ala

565 570 575Val Glu Gln Thr Asp Pro Glu Ile Ser Glu Ala Ile Asp Phe Ala Arg

580 585 590Tyr Tyr Ala His Leu Ala Leu Glu Leu Asp Asp Val Asp Asn Ala Glu

595 600 605Phe Thr Pro Asp Arg Val Val Val Val Thr Pro Pro Trp Asn Phe Pro

610 615 620Ile Ala Ile Pro Ala Gly Ser Thr Phe Ala Ala Leu Ala Ala Gly Ala625 630 635 640Gly Val Ile His Lys Pro Ser Lys Pro Ser Gln His Cys Ser Ala Ala

645 650 655Val Val Glu Ala Leu Trp Glu Ala Gly Val Pro Arg Glu Val Leu His

660 665 670Cys Ile Tyr Pro Ala Asn Arg Asp Val Gly Cys Ala Leu Ile Ser His

675 680 685Glu His Val Asp Arg Val Ile Leu Thr Gly Ser Ser Glu Thr Ala Ala

690 695 700Met Phe Ser Ser Trp Arg Pro Glu Leu Thr Ile Asn Gly Glu Thr Ser705 710 715 720Gly Lys Asn Ala Ile Val Val Thr Pro Ser Ala Asp Arg Asp Leu Ala

725 730 735Val Ala Asp Leu Val Lys Ser Ala Phe Gly His Ala Gly Gln Lys Cys

740 745 750Ser Ala Ala Ser Leu Gly Ile Leu Val Gly Ser Val Tyr Glu Ser Glu

755 760 765Arg Phe Arg Lys Gln Leu Val Asp Ala Ala Ser Ser Leu Ile Val Asp

770 775 780Trp Pro Thr Asn Pro Ser Ala Thr Val Gly Pro Leu Thr Glu Leu Pro785 790 795 800Ser Asp Lys Leu His His Ala Leu Thr Thr Leu Glu Glu Gly Glu Ser

805 810 815Trp Leu Leu Lys Pro Arg Gln Leu Asp Asp Thr Gly Arg Leu Trp Ser

820 825 830Pro Gly Ile Lys Glu Gly Val Lys Pro Gly Thr Phe Phe His Leu Thr

835 840 845Glu Val Phe Gly Pro Val Leu Gly Leu Met Lys Ala Thr Asp Leu Asn

850 855860Glu Ala Ile Glu Phe Gln Asn Gly Asn Asp Phe Gly Leu Thr Gly Gly865 870 875 880Leu Gln Ser Leu Asp Ala Asp Glu Val Arg Thr Trp Leu Asp His Val

885 890 895Asp Val Gly Asn Ala Tyr Val Asn Arg Gly Ile Thr Gly Ala Ile Val

900 905 910Gln Arg Gln Ser Phe Gly Gly Trp Lys Lys Ser Ser Val Gly Leu Gly

915 920 925Ser Lys Ala Gly Gly Pro Asn Tyr Val Met Leu Met Gly Thr Trp Ala

930 935 940Asp Ala Pro Ser His His Ala Pro Arg Glu Thr Asn Pro Leu Ile Ser945 950 955 960Lys Leu Asp Leu Pro Gly Glu Glu Leu Glu Trp Leu Glu Lys Ala Asn

965 970 975Ala Ser Asp Glu Thr Ala Trp Asn Thr Glu Phe Gly Ser Pro Arg Asp

980 985 990Pro Ser Gly Leu Asp Val Glu Ala Asn Ile Phe Arg Tyr Arg Pro Ala

99510001005<210>313<211>927<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (904)<223>RXC02498<400>313caaggtagaa atttgtccgt gggcacttcg tgaaggtgtg atcctcacca ggatcgacaa 60aggactcgag taacatttac ccggaaagga gttggcgaaa atg agt gaa gag aaa 115

Met Ser Glu Glu Lys

1 5ctc aca gtc gct gag ctg atg gcg cgt gcc gcg aaa gag gga cgc tcc 163Leu Thr Val Ala Glu Leu Met Ala Arg Ala Ala Lys Glu Gly Arg Ser

10 15 20acc gat gct ccc cga cga cgc agg cgc cgc agc atc gaa gac ggt ggc 211Thr Asp Ala Pro Arg Arg Arg Arg Arg Arg Ser Ile Glu Asp Gly Gly

25 30 35gta tcc gtt gct gag ctg acc ggc tcc att cct gcc gtt aag gaa aag 259Val Ser Val Ala Glu Leu Thr Gly Ser Ile Pro Ala Val Lys Glu Lys

40 45 50ccc gcg gag tcc aag cac tcc agc gtg ccc atc gat gca cca gca gaa 307Pro Ala Glu Ser Lys His Ser Ser Val Pro Ile Asp Ala Pro Ala Glu

55 60 65cct gag gtt gtt gag gcc ccc aag cct gag ccc gcc gaa gaa gta gaa 355Pro Glu Val Val Glu Ala Pro Lys Pro Glu Pro Ala Glu Glu Val Glu 70 75 80 85gtg gct tcg gtg gag ggc gac gtc gat aag cag gaa acc cct gag cgt 403Val Ala Ser Val Glu Gly Asp Val Asp Lys Gln Glu Thr Pro Glu Arg

90 95 100ccg gcg ccg agc aac gaa gaa acc atg gtg ctg cgc atc gtg gat gaa 451Pro Ala Pro Ser Asn Glu Glu Thr Met Val Leu Arg Ile Val Asp Glu

105 110 115aaa gat cca att agc ttg acg acg ggc gcg ttc ccc gtg gtt ccg gca 499Lys Asp Pro Ile Ser Leu Thr Thr Gly Ala Phe Pro Val Val Pro Ala

120 125 130gtt gcc gcc aag ccg gcg ccc gta gtg cgc gcg gag aag gac gcc gat 547Val Ala Ala Lys Pro Ala Pro Val Val Arg Ala Glu Lys Asp Ala Asp

135 140 145gtg gag act gcc gta aag gca gat ttc gca gag gtg gaa gtc gat aac 595Val Glu Thr Ala Val Lys Ala Asp Phe Ala Glu Val Glu Val Asp Asn150 155 160 165act gac acc acg cag atg gct gtg gtg gaa gaa gtt gac gag gag cca 643Thr Asp Thr Thr Gln Met Ala Val Val Glu Glu Val Asp Glu Glu Pro

170 175 180gag caa gaa aac aaa atg tcc gta ttc gcg atc atc atg atg gcg atc 691Glu Gln Glu Asn Lys Met Ser Val Phe Ala Ile Ile Met Met Ala Ile

185 190 195gtc gga gtt gtt ctc ggt gtc gtt gta ttc ctc ggc ttt gaa atg ctg 739Val Gly Val Val Leu Gly Val Val Val Phe Leu Gly Phe Glu Met Leu

200 205 210tgg gag cgc ctg aac aag tgg atc gtc gct gtt ctg gca gtc ggc gtg 787Trp Glu Arg Leu Asn Lys Trp Ile Val Ala Val Leu Ala Val Gly Val

215 220 225acc ttg gga atg gtg ggc atc atc cac gct ttg cgc acc tca cgt gat 835Thr Leu Gly Met Val Gly Ile Ile His Ala Leu Arg Thr Ser Arg Asp230 235 240 245ggt ttc agc atg gtt ctc gca gga atc gtg ggc ctg gtc atg acg ttc 883Gly Phe Ser Met Val Leu Ala Gly Ile Val Gly Leu Val Met Thr Phe

250 255 260ggg ccg ctg gca atc gtc atg taatttgtcg ttttgggccc ccg 927Gly Pro Leu Ala Ile Val Met

265<210>314<211>268<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>314Met Ser Glu Glu Lys Leu Thr Val Ala Glu Leu Met Ala Arg Ala Ala 151015 Lys Glu Gly Arg Ser Thr Asp Ala Pro Arg Arg Arg Arg Arg Arg Ser

20 25 30Ile Glu Asp Gly Gly Val Ser Val Ala Glu Leu Thr Gly Ser Ile Pro

35 40 45Ala Val Lys Glu Lys Pro Ala Glu Ser Lys His Ser Ser Val Pro Ile

50 55 60Asp Ala Pro Ala Glu Pro Glu Val Val Glu Ala Pro Lys Pro Glu Pro 65 7075 80Ala Glu Glu Val Glu Val Ala Ser Val Glu Gly Asp Val Asp Lys Gln

85 90 95Glu Thr Pro Glu Arg Pro Ala Pro Ser Asn Glu Glu Thr Met Val Leu

100 105 110Arg Ile Val Asp Glu Lys Asp Pro Ile Ser Leu Thr Thr Gly Ala Phe

115 120 125Pro Val Val Pro Ala Val Ala Ala Lys Pro Ala Pro Val Val Arg Ala

130 135 140Glu Lys Asp Ala Asp Val Glu Thr Ala Val Lys Ala Asp Phe Ala Glu145 150 155 160Val Glu Val Asp Asn Thr Asp Thr Thr Gln Met Ala Val Val Glu Glu

165 170 175Val Asp Glu Glu Pro Glu Gln Glu Asn Lys Met Ser Val Phe Ala Ile

180 185 190Ile Met Met Ala Ile Val Gly Val Val Leu Gly Val Val Val Phe Leu

195 200 205Gly Phe Glu Met Leu Trp Glu Arg Leu Asn Lys Trp Ile Val Ala Val

210 215 220Leu Ala Val Gly Val Thr Leu Gly Met Val Gly Ile Ile His Ala Leu225 230 235 240Arg Thr Ser Arg Asp Gly Phe Ser Met Val Leu Ala Gly Ile Val Gly

245 250 255Leu Val Met Thr Phe Gly Pro Leu Ala Ile Val Met

260265<210>315<211>774<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (751)<223>RXA01491<400>315aacggtgtga aacacattga agtgtcgttg ggttatccgc gcgaatggga gcattggtct 60gggcagcatg tgtggccata tccagtgatg gaggtggaca atg ctg gat gag tct 115

Met Leu Asp Glu Ser

1 5ttg ttt cca aat tcg gca aag ttt tct ttc att aaa act ggc gat gct 163Leu Phe Pro Asn Ser Ala Lys Phe Ser Phe Ile Lys Thr Gly Asp Ala

10 15 20gtt aat tta gac cat ttc cat cag ttg cat ccg ttg gaa aag gca ctg 211Val Asn Leu Asp His Phe His Gln Leu His Pro Leu Glu Lys Ala Leu

25 30 35gta gcg cac tcg gtt gat att aga aaa gca gag ttt gga gat gcc agg 259Val Ala His Ser Val Asp Ile Arg Lys Ala Glu Phe Gly Asp Ala Arg

40 45 50tgg tgt gca cat cag gca ctc caa gct ttg gga cga gat agc ggt gat 307Trp Cys Ala His Gln Ala Leu Gln Ala Leu Gly Arg Asp Ser Gly Asp

55 60 65ccc att ttg cgt ggg gaa cga gga atg cca ttg tgg cct tct tcg gtg 355Pro Ile Leu Arg Gly Glu Arg Gly Met Pro Leu Trp Pro Ser Ser Val 70 75 80 85tct ggt tca ttg acc cac act gac gga ttc cga gct gct gtt gtg gcg 403Ser Gly Ser Leu Thr His Thr Asp Gly Phe Arg Ala Ala Val Val Ala

90 95 100cca cga ttg ttg gtg cgt tct atg gga ttg gat gcc gaa cct gcg gag 451Pro Arg Leu Leu Val Arg Ser Met Gly Leu Asp Ala Glu Pro Ala Glu

105 110 115ccg ttg ccc aag gat gtt ttg ggt tca atc gct cgg gtg ggg gag att 499Pro Leu Pro Lys Asp Val Leu Gly Ser Ile Ala Arg Val Gly Glu Ile

120 125 130cct caa ctt aag cgc ttg gag gaa caa ggt gtg cac tgc gcg gat cgc 547Pro Gln Leu LysArg Leu Glu Glu Gln Gly Val His Cys Ala Asp Arg

135 140 145ctg ctg ttt tgt gcc aag gaa gca aca tac aaa gcg tgg ttc ccg ctg 595Leu Leu Phe Cys Ala Lys Glu Ala Thr Tyr Lys Ala Trp Phe Pro Leu150 155 160 165acg cat agg tgg ctt ggt ttt gaa caa gct gag atc gac ttg cgt gat 643Thr His Arg Trp Leu Gly Phe Glu Gln Ala Glu Ile Asp Leu Arg Asp

170 175 180gat ggc act ttt gtg tcc tat ttg ctg gtt cga cca act cca gtg ccg 691Asp Gly Thr Phe Val Ser Tyr Leu Leu Val Arg Pro Thr Pro Val Pro

185 190 195ttt att tca ggt aaa tgg gta ctg cgt gat ggt tat gtc ata gct gcg 739Phe Ile Ser Gly Lys Trp Val Leu Arg Asp Gly Tyr Val Ile Ala Ala

200 205 210act gca gtg act tgaactggat ggagaggata cct 774Thr Ala Val Thr

215<210>316<211>217<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>316Met Leu Asp Glu Ser Leu Phe Pro Asn Ser Ala Lys Phe Ser Phe Ile 151015 Lys Thr Gly Asp Ala Val Asn Leu Asp His Phe His Gln Leu His Pro

20 25 30Leu Glu Lys Ala Leu Val Ala His Ser Val Asp Ile Arg Lys Ala Glu

35 40 45Phe Gly Asp Ala Arg Trp Cys Ala His Gln Ala Leu Gln Ala Leu Gly

50 55 60Arg Asp Ser Gly Asp Pro Ile Leu Arg Gly Glu Arg Gly Met Pro Leu 65 70 75 80Trp Pro Ser Ser Val Ser Gly Ser Leu Thr His Thr Asp Gly Phe Arg

85 90 95Ala Ala Val Val Ala Pro Arg Leu Leu Val Arg Ser Met Gly Leu Asp

100 105 110Ala Glu Pro Ala Glu Pro Leu Pro Lys Asp Val Leu Gly Ser Ile Ala

115 120 125Arg Val Gly Glu Ile Pro Gln Leu Lys Arg Leu Glu Glu Gln Gly Val

130 135 140His Cys Ala Asp Arg Leu Leu Phe Cys Ala Lys Glu Ala Thr Tyr Lys145 150 155 160Ala Trp Phe Pro Leu Thr His Arg Trp Leu Gly Phe Glu Gln Ala Glu

165 170 175Ile Asp Leu Arg Asp Asp Gly Thr Phe Val Ser Tyr Leu Leu Val Arg

180 185 190Pro Thr Pro Val Pro Phe Ile Ser Gly Lys Trp Val Leu Arg Asp Gly

195 200 205Tyr Val Ile Ala Ala Thr Ala Val Thr

210215<210>317<211>1287<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1264)<223>RXA02155<400>317tcggcgtcgc accttaaagt agcgccttaa agcggcgctt caaaccaagc gccctaacca 60gcaaacacaa caaacacatc taattcagta ggagttccac atg gca gaa aaa ggc 115

Met Ala Glu Lys Gly

1 5att acc gcg ccg aaa ggc ttc gtt gct tct gca acg acc gcg ggt att 163Ile Thr Ala Pro Lys Gly Phe Val Ala Ser Ala Thr Thr Ala Gly Ile

10 15 20aaa gct tct ggc aat cct gac atg gcg ttg gtg gtt aac cag ggt cca 211Lys Ala Ser Gly Asn Pro Asp Met Ala Leu Val Val Asn Gln Gly Pro

25 30 35gag ttt tcc gca gcg gcc gtg ttt aca cgt aac cga gtt ttc gca gcg 259Glu Phe Ser Ala Ala Ala Val Phe Thr Arg Asn Arg Val Phe Ala Ala

40 45 50cct gtg aag gtg agc cga gag aac gtt gct gat ggc cag atc agg gct 307Pro Val Lys Val Ser Arg Glu Asn Val Ala Asp Gly Gln Ile Arg Ala

55 60 65gtt ttg tac aac gct ggt aat gct aat gcg tgt aat ggt ctg cag ggt 355Val Leu Tyr Asn Ala Gly Asn Ala Asn Ala Cys Asn Gly Leu Gln Gly 70 75 80 85gag aag gat gct cgt gag tct gtt tct cat cta gct caa aat ttg ggc 403Glu Lys Asp Ala Arg Glu Ser Val Ser His Leu Ala Gln Asn Leu Gly

90 95 100ttg gag gat tcc gat att ggt gtg tgt tcc act ggt ctt att ggt gag 451Leu Glu Asp Ser Asp Ile Gly Val Cys Ser Thr Gly Leu Ile Gly Glu

105 110 115ttg ctt ccg atg gat aag ctc aat gca ggt att gat cag ctg acc gct 499Leu Leu Pro Met Asp Lys Leu Asn Ala Gly Ile Asp Gln Leu Thr Ala

120 125 130gag ggc gct ttg ggt gac aat ggt gca gct gct gcc aag gcg atc atg 547Glu Gly Ala Leu Gly Asp Asn Gly Ala Ala Ala Ala Lys Ala Ile Met

135 140 145acc act gac acg gtg gat aag gaa acc gtc gtg ttt gct gat ggt tgg 595Thr Thr Asp Thr Val Asp Lys Glu Thr Val Val Phe Ala Asp Gly Trp150 155 160 165act gtc ggc gga atg ggc aag ggc gtg ggc atg atg gcg ccg tct ctt 643Thr Val Gly Gly Met Gly Lys Gly Val Gly Met Met Ala Pro Ser Leu

170 175 180gcc acc atg ctg gtc tgc ttg acc act gat gca tcc gtt act cag gaa 691Ala Thr Met Leu Val Cys Leu Thr Thr Asp Ala Ser Val Thr Gln Glu

185 190 195atg gct cag atc gcg ctg gct aat gct acg gcc gtt acg ttt gac acc 739Met Ala Gln Ile Ala Leu Ala Asn Ala Thr Ala Val Thr Phe Asp Thr

200 205 210ctg gat att gat gga tca acc tcc acc aat gac acc gtg ttc ctg ctg 787Leu Asp Ile Asp Gly Ser Thr Ser Thr Asn Asp Thr Val Phe Leu Leu

215 220 225gca tct ggc gct agc gga atc acc cca act cag gat gaa ctc aac gat 835Ala Ser Gly Ala Ser Gly Ile Thr Pro Thr Gln Asp Glu Leu Asn Asp230 235 240 245gcg gtg tac gca gct tgt tct gat atc gca gcg aag ctt cag gct gat 883Ala Val Tyr Ala Ala Cys Ser Asp Ile Ala Ala Lys Leu Gln Ala Asp

250 255 260gca gag ggt gtg acc aag cgc gtt gct gtg aca gtg gtg gga acc acc 931Ala Glu Gly Val Thr Lys Arg Val Ala Val Thr Val Val Gly Thr Thr

265 270 275aac aac gag cag gcg att aat gcg gct cgc act gtt gct cgt gac aat 979Asn Asn Glu Gln Ala Ile Asn Ala Ala Arg Thr Val Ala Arg Asp Asn

280 285 290ttg ttc aag tgc gca atg ttt gga tct gat cca aac tgg ggt cgc gtg 1027Leu Phe Lys Cys Ala Met Phe Gly Ser Asp Pro Asn Trp Gly Arg Val

295 300 305ttg gct gca gtc ggc atg gct gat gct gat atg gaa cca gag aag att 1075Leu Ala Ala Val Gly Met Ala Asp Ala Asp Met Glu Pro Glu Lys Ile310 315 320 325tct gtg ttc ttc aat ggt caa gca gta tgc ctt gat tcc act ggc gct 1123Ser Val Phe Phe Asn Gly Gln Ala Val Cys Leu Asp Ser Thr Gly Ala

330335 340cct ggt gct cgt gag gtg gat ctt tcc ggc gct gac att gat gtc cga 1171Pro Gly Ala Arg Glu Val Asp Leu Ser Gly Ala Asp Ile Asp Val Arg

345 350 355att gat ttg ggc acc agt ggg gaa ggc cag gca aca gtt cga acc act 1219Ile Asp Leu Gly Thr Ser Gly Glu Gly Gln Ala Thr Val Arg Thr Thr

360 365 370gac ctg agc ttc tcc tac gtg gag atc aac tcc gcg tac agc tct 1264Asp Leu Ser Phe Ser Tyr Val Glu Ile Asn Ser Ala Tyr Ser Ser

375380385 taaaaagaaa cagcactcca act 1287<210>318<211>388<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>318Met Ala Glu Lys Gly Ile Thr Ala Pro Lys Gly Phe Val Ala Ser Ala 151015 Thr Thr Ala Gly Ile Lys Ala Ser Gly Asn Pro Asp Met Ala Leu Val

20 25 30Val Asn Gln Gly Pro Glu Phe Ser Ala Ala Ala Val Phe Thr Arg Asn

35 40 45Arg Val Phe Ala Ala Pro Val Lys Val Ser Arg Glu Asn Val Ala Asp

50 55 60Gly Gln Ile Arg Ala Val Leu Tyr Asn Ala Gly Asn Ala Asn Ala Cys 65 70 75 80Asn Gly Leu Gln Gly Glu Lys Asp Ala Arg Glu Ser Val Ser His Leu

85 90 95Ala Gln Asn Leu Gly Leu Glu Asp Ser Asp Ile Gly Val Cys Ser Thr

100 105 110Gly Leu Ile Gly Glu Leu Leu Pro Met Asp Lys Leu Asn Ala Gly Ile

115 120 125Asp Gln Leu Thr Ala Glu Gly Ala Leu Gly Asp Asn Gly Ala Ala Ala

130 135140Ala Lys Ala Ile Met Thr Thr Asp Thr Val Asp Lys Glu Thr Val Val145 150 155 160Phe Ala Asp Gly Trp Thr Val Gly Gly Met Gly Lys Gly Val Gly Met

165 170 175Met Ala Pro Ser Leu Ala Thr Met Leu Val Cys Leu Thr Thr Asp Ala

180 185 190Ser Val Thr Gln Glu Met Ala Gln Ile Ala Leu Ala Asn Ala Thr Ala

195 200 205Val Thr Phe Asp Thr Leu Asp Ile Asp Gly Ser Thr Ser Thr Asn Asp

210 215 220Thr Val Phe Leu Leu Ala Ser Gly Ala Ser Gly Ile Thr Pro Thr Gln225 230 235 240Asp Glu Leu Asn Asp Ala Val Tyr Ala Ala Cys Ser Asp Ile Ala Ala

245 250 255Lys Leu Gln Ala Asp Ala Glu Gly Val Thr Lys Arg Val Ala Val Thr

260 265 270Val Val Gly Thr Thr Asn Asn Glu Gln Ala Ile Asn Ala Ala Arg Thr

275 280 285Val Ala Arg Asp Asn Leu Phe Lys Cys Ala Met Phe Gly Ser Asp Pro

290 295 300Asn Trp Gly Arg Val Leu Ala Ala Val Gly Met Ala Asp Ala Asp Met305 310 315 320Glu Pro Glu Lys Ile Ser Val Phe Phe Asn Gly Gln Ala Val Cys Leu

325 330 335Asp Ser Thr Gly Ala Pro Gly Ala Arg Glu Val Asp Leu Ser Gly Ala

340 345 350Asp Ile Asp Val Arg Ile Asp Leu Gly Thr Ser Gly Glu Gly Gln Ala

355 360365Thr Val Arg Thr Thr Asp Leu Ser Phe Ser Tyr Val Glu Ile Asn Ser

370375380 Ala Tyr Ser Ser385<210>319<211>1074<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1051)<223>RXA02156<400>319aaccactgac ctgagcttct cctacgtgga gatcaactcc gcgtacagct cttaaaaaga 60aacagcactc caactaacaa gcagggaaaa gggcacaggc atg aat gac ttg atc 115

Met Asn Asp Leu Ile

1 5aaa gat tta ggc tct gag gtg cgc gca aat gtc ctc gct gag gcg ttg 163Lys Asp Leu Gly Ser Glu Val Arg Ala Asn Val Leu Ala Glu Ala Leu

10 15 20cca tgg ttg cag cac ttc cgc gac aag att gtt gtc gtg aaa tat ggc 211Pro Trp Leu Gln His Phe Arg Asp Lys Ile Val Val Val Lys Tyr Gly

25 30 35gga aac gcc atg gtg gat gat gat ctc aag gct gct ttt gct gcc gac 259Gly Asn Ala Met Val Asp Asp Asp Leu Lys Ala Ala Phe Ala Ala Asp

40 45 50atg gtc ttc ttg cgc acc gtg ggc gca aaa cca gtg gtg gtg cac ggt 307Met Val Phe Leu Arg Thr Val Gly Ala Lys Pro Val Val Val His Gly

55 60 65ggt gga cct cag att tct gag atg cta aac cgt gtg ggt ctc cag ggc 355Gly Gly Pro Gln Ile Ser Glu Met Leu Asn Arg Val Gly Leu Gln Gly 70 75 80 85gag ttc aag ggt ggt ttc cgt gtg acc act cct gag gtc atg gac att 403Glu Phe Lys Gly Gly Phe Arg Val Thr Thr Pro Glu Val Met Asp Ile

90 95 100gtg cgc atg gtg ctc ttt ggt cag gtc ggt cgc gat tta gttggt ttg 451Val Arg Met Val Leu Phe Gly Gln Val Gly Arg Asp Leu Val Gly Leu

105 110 115atc aac tct cat ggc cct tac gct gtg gga acc tcc ggt gag gat gcc 499Ile Asn Ser His Gly Pro Tyr Ala Val Gly Thr Ser Gly Glu Asp Ala

120 125 130ggc ctg ttt acc gcg cag aag cgc atg gtc aac atc gat ggc gta ccc 547Gly Leu Phe Thr Ala Gln Lys Arg Met Val Asn Ile Asp Gly Val Pro

135 140 145act gat att ggt ttg gtc gga gac atc att aat gtc gat gcc tct tcc 595Thr Asp Ile Gly Leu Val Gly Asp Ile Ile Asn Val Asp Ala Ser Ser150 155 160 165ttg atg gat atc atc gag gcc ggt cgc att cct gtg gtc tct acg att 643Leu Met Asp Ile Ile Glu Ala Gly Arg Ile Pro Val Val Ser Thr Ile

170 175 180gct cca ggc gaa gac ggc cag att tac aac att aac gcc gat acc gca 691Ala Pro Gly Glu Asp Gly Gln Ile Tyr Asn Ile Asn Ala Asp Thr Ala

185 190 195gca ggt gct ttg gct gca gcg att ggt gca gaa cgc ctg ctg gtt ctc 739Ala Gly Ala Leu Ala Ala Ala Ile Gly Ala Glu Arg Leu Leu Val Leu

200 205 210acc aat gtg gaa ggt ctg tac acc gat tgg cct gat aag agc tca ctg 787Thr Asn Val Glu Gly Leu Tyr Thr Asp Trp Pro Asp Lys Ser Ser Leu

215 220 225gtg tcc aag atc aag gcc acc gag ctg gag gcc att ctt ccg gga ctt 835Val Ser Lys Ile Lys Ala Thr Glu Leu Glu Ala Ile Leu Pro Gly Leu230 235 240 245gat tcc ggc atg att cca aag atg gag tct tgc ttg aac gcg gtg cgt 883Asp Ser Gly Met Ile Pro Lys Met Glu Ser Cys Leu Asn Ala Val Arg

250255 260ggg gga gta agc gct gct cat gtc att gac ggc cgc atc gcg cac tcg 931Gly Gly Val Ser Ala Ala His Val Ile Asp Gly Arg Ile Ala His Ser

265 270 275gtg ttg ctg gag ctt ttg acc atg ggt gga att ggc acg atg gtg ctg 979Val Leu Leu Glu Leu Leu Thr Met Gly Gly Ile Gly Thr Met Val Leu

280 285 290ccg gat gtt ttt gat cgg gag aat tat cct gaa ggc acc gtt ttt aga 1027Pro Asp Val Phe Asp Arg Glu Asn Tyr Pro Glu Gly Thr Val Phe Arg

295300305 aaa gac gac aag gat ggg gaa ctg taaatgagca cgctggaaac ttg 1074Lys Asp Asp Lys Asp Gly Glu Leu 310315<210>320<211>317<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>320Met Asn Asp Leu Ile Lys Asp Leu Gly Ser Glu Val Arg Ala Asn Val 151015 Leu Ala Glu Ala Leu Pro Trp Leu Gln His Phe Arg Asp Lys Ile Val

20 25 30Val Val Lys Tyr Gly Gly Asn Ala Met Val Asp Asp Asp Leu Lys Ala

35 40 45Ala Phe Ala Ala Asp Met Val Phe Leu Arg Thr Val Gly Ala Lys Pro

50 55 60Val Val Val His Gly Gly Gly Pro Gln Ile Ser Glu Met Leu Asn Arg 65 70 75 80Val Gly Leu Gln Gly Glu Phe Lys Gly Gly Phe Arg Val Thr Thr Pro

85 90 95Glu Val Met Asp Ile Val Arg Met Val Leu Phe Gly Gln Val Gly Arg

100 105 110Asp Leu Val Gly Leu Ile Asn Ser His Gly Pro Tyr Ala Val Gly Thr

115 120 125Ser Gly Glu Asp Ala Gly Leu Phe Thr Ala Gln Lys Arg Met Val Asn

130 135 140Ile Asp Gly Val Pro Thr Asp Ile Gly Leu Val Gly Asp Ile Ile Asn145 150 155 160Val Asp Ala Ser Ser Leu Met Asp Ile Ile Glu Ala Gly Arg Ile Pro

165 170 175Val Val Ser Thr Ile Ala Pro Gly Glu Asp Gly Gln Ile Tyr Asn Ile

180 185 190Asn Ala Asp Thr Ala Ala Gly Ala Leu Ala Ala Ala Ile Gly Ala Glu

195 200 205Arg Leu Leu Val Leu Thr Asn Val Glu Gly Leu Tyr Thr Asp Trp Pro

210 215 220Asp Lys Ser Ser Leu Val Ser Lys Ile Lys Ala Thr Glu Leu Glu Ala225 230 235 240Ile Leu Pro Gly Leu Asp Ser Gly Met Ile Pro Lys Met Glu Ser Cys

245 250 255Leu Asn Ala Val Arg Gly Gly Val Ser Ala Ala His Val Ile Asp Gly

260 265 270Arg Ile Ala His Ser Val Leu Leu Glu Leu Leu Thr Met Gly Gly Ile

275 280 285Gly Thr Met Val Leu Pro Asp Val Phe Asp Arg Glu Asn Tyr Pro Glu

290295300 Gly Thr Val Phe Arg Lys Asp Asp Lys Asp Gly Glu Leu 305310315<210>321<211>903<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (880)<223>RXN02153<400>321cccacttgca gttttagctg taggtgggtt tttgcatgtc taacccgtct tttatgcaca 60cccccgcaat gaatcaaaaa tttatgcatg aataatttgc atg atc atg cat aac 115

Met Ile Met His Asn

1 5gtg tat ggt gta act atg aca atc aag gtt gca atc gca gga gcc agt 163Val Tyr Gly Val Thr Met Thr Ile Lys Val Ala Ile Ala Gly Ala Ser

10 15 20gga tat gcc ggc gga gaa atc ctt cgt ctc ctt tta ggc cat cca gct 211Gly Tyr Ala Gly Gly Glu Ile Leu Arg Leu Leu Leu Gly His Pro Ala

25 30 35tat gca tct ggt gaa cta gaa atc gga gca ctc acc gcg gca tca acc 259Tyr Ala Ser Gly Glu Leu Glu Ile Gly Ala Leu Thr Ala Ala Ser Thr

40 45 50gca ggc agc acg ctc ggt gaa ttg atg cca cac att ccg cag ttg gcg 307Ala Gly Ser Thr Leu Gly Glu Leu Met Pro His Ile Pro Gln Leu Ala

55 60 65gat cgt gtt att caa gac acc aca gct gaa act cta gcc ggt cat gat 355Asp Arg Val Ile Gln Asp Thr Thr Ala Glu Thr Leu Ala Gly His Asp 70 75 80 85gtc gta ttt cta gga ctt cca cac gga ttc tct gca gaa att gca ctt 403Val Val Phe Leu Gly Leu Pro His Gly Phe Ser Ala Glu Ile Ala Leu

90 95 100cag ctc gga cca gat gtc aca gtg att gac tgt gca gct gac ttt cgt 451Gln Leu Gly Pro Asp Val Thr Val Ile Asp Cys Ala Ala Asp Phe Arg

105 110 115ctg caa aat gct gca gat tgg gag aag ttc tac ggc tca gag cac cag 499Leu Gln Asn Ala Ala Asp Trp Glu Lys Phe Tyr Gly Ser Glu His Gln

120 125 130gga aca tgg cct tat ggc att cca gaa atg cca gga cac cgc gag gct 547Gly Thr Trp Pro Tyr Gly Ile Pro Glu Met Pro Gly His Arg Glu Ala

135 140 145ctt cgt ggt gct aag cgt gta gca gtg cca gga tgt ttc cca acc ggt 595Leu Arg Gly Ala Lys Arg Val Ala Val Pro Gly Cys Phe Pro Thr Gly150 155 160 165gca acc ttg gct ctt ctt cct gcg gtt caa gcg gga ctt atc gag cca 643Ala Thr Leu Ala Leu Leu Pro Ala Val Gln Ala Gly Leu Ile Glu Pro

170 175 180gat gtt tcc gta gtg tcc atc acc ggc gta tca ggt gca ggt aag aaa 691Asp Val Ser Val Val Ser Ile Thr Gly Val Ser Gly Ala Gly Lys Lys

185 190 195gca tct gtt gca cta ctt ggc tcg gaa acc atg ggt tca ctc aag gcg 739Ala Ser Val Ala Leu Leu Gly Ser Glu Thr Met Gly Ser Leu Lys Ala

200 205 210tac aac acc tcc gga aag cac cgc cac acc ccg gaa att gcc cag aac 787Tyr Asn Thr Ser Gly Lys His Arg His Thr Pro Glu Ile Ala Gln Asn

215 220 225ctc ggc gaa gtc agc gac aag cca gtc aag gtg agc ttc acc cca gtg 835Leu Gly Glu Val Ser Asp Lys Pro Val Lys Val Ser Phe Thr Pro Val230 235 240 245ctt gca ccg tta cct cgc gaa ttc tca cca ctg caa ccg cac ctt 880Leu Ala Pro Leu Pro Arg Glu Phe Ser Pro Leu Gln Pro His Leu

250255260 tgaaagaagg cgttaccgca gaa 903<210>322<211>260<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>322Met Ile Met His Asn Val Tyr Gly Val Thr Met Thr Ile Lys Val Ala 151015 Ile Ala Gly Ala Ser Gly Tyr Ala Gly Gly Glu Ile Leu Arg Leu Leu

20 25 30Leu Gly His Pro Ala Tyr Ala Ser Gly Glu Leu Glu Ile Gly Ala Leu

35 40 45Thr Ala Ala Ser Thr Ala Gly Ser Thr Leu Gly Glu Leu Met Pro His

50 55 60Ile Pro Gln Leu Ala Asp Arg Val Ile Gln Asp Thr Thr Ala Glu Thr 65 70 75 80Leu Ala Gly His Asp Val Val Phe Leu Gly Leu Pro His Gly Phe Ser

85 90 95Ala Glu Ile Ala Leu Gln Leu Gly Pro Asp Val Thr Val Ile Asp Cys

100 105 110Ala Ala Asp Phe Arg Leu Gln Asn Ala Ala Asp Trp Glu Lys Phe Tyr

115 120 125Gly Ser Glu His Gln Gly Thr Trp Pro Tyr Gly Ile Pro Glu Met Pro

130 135 140Gly His Arg Glu Ala Leu Arg Gly Ala Lys Arg Val Ala Val Pro Gly145 150 155 160Cys Phe Pro Thr Gly Ala Thr Leu Ala Leu Leu Pro Ala Val Gln Ala

165 170 175Gly Leu Ile Glu Pro Asp Val Ser Val Val Ser Ile Thr Gly Val Ser

180 185 190Gly Ala Gly Lys Lys Ala Ser Val Ala Leu Leu Gly Ser Glu Thr Met

195 200 205Gly Ser Leu Lys Ala Tyr Asn Thr Ser Gly Lys His Arg His Thr Pro

210 215 220Glu Ile Ala Gln Asn Leu Gly Glu Val Ser Asp Lys Pro Val Lys Val225 230 235 240Ser Phe Thr Pro Val Leu Ala Pro Leu Pro Arg Glu Phe Ser Pro Leu

245 250 255Gln Pro His Leu

260<210>323<211>903<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (880)<223>FRXA02153<400>323cccacttgca gttttagctg taggtgggtt tttgcatgtc taacccgtct tttatgcaca 60cccccgcaat gaatcaaaaa tttatgcatg aataatttgc atg atc atg cat aac 115

Met Ile Met His Asn

1 5gtg tat ggt gta act atg aca atc aag gtt gca atc gca gga gcc agt 163Val Tyr Gly Val Thr Met Thr Ile Lys Val Ala Ile Ala Gly Ala Ser

10 15 20gga tat gcc ggc gga gaa atc ctt cgt ctc ctt tta ggc cat cca gct 211Gly Tyr Ala Gly Gly Glu Ile Leu Arg Leu Leu Leu Gly His Pro Ala

25 30 35tat gca tct ggt gaa cta gaa atc gga gca ctc acc gcg gca tca acc 259Tyr Ala Ser Gly Glu Leu Glu Ile Gly Ala Leu Thr Ala Ala Ser Thr

40 45 50gca ggc agc acg ctc ggt gaa ttg atg cca cac att ccg cag ttg gcg 307Ala Gly Ser Thr Leu Gly Glu Leu Met Pro His Ile Pro Gln Leu Ala

55 60 65gat cgt gtt att caa gac acc aca gct gaa act cta gcc ggt cat gat 355Asp Arg Val Ile Gln Asp Thr Thr Ala Glu Thr Leu Ala Gly His Asp 70 75 80 85gtc gta ttt cta gga ctt cca cac gga ttc tct gca gaa att gca ctt 403Val Val Phe Leu Gly Leu Pro His Gly Phe Ser Ala Glu Ile Ala Leu

90 95 100cag ctc gga cca gat gtc aca gtg att gac tgt gca gct gac ttt cgt 451Gln Leu Gly Pro Asp Val Thr Val Ile Asp Cys Ala Ala Asp Phe Arg

105 110 115ctg caa aat gct gca gat tgg gag aag ttc tac ggc tca gag cac cag 499Leu Gln Asn Ala Ala Asp Trp Glu Lys Phe Tyr Gly Ser Glu His Gln

120125 130gga aca tgg cct tat ggc att cca gaa atg cca gga cac cgc gag gct 547Gly Thr Trp Pro Tyr Gly Ile Pro Glu Met Pro Gly His Arg Glu Ala

135 140 145ctt cgt ggt gct aag cgt gta gca gtg cca gga tgt ttc cca acc ggt 595Leu Arg Gly Ala Lys Arg Val Ala Val Pro Gly Cys Phe Pro Thr Gly150 155 160 165gca acc ttg gct ctt ctt cct gcg gtt caa gcg gga ctt atc gag cca 643Ala Thr Leu Ala Leu Leu Pro Ala Val Gln Ala Gly Leu Ile Glu Pro

170 175 180gat gtt tcc gta gtg tcc atc acc ggc gta tca ggt gca ggt aag aaa 691Asp Val Ser Val Val Ser Ile Thr Gly Val Ser Gly Ala Gly Lys Lys

185 190 195gca tct gtt gca cta ctt ggc tcg gaa acc atg ggt tca ctc aag gcg 739Ala Ser Val Ala Leu Leu Gly Ser Glu Thr Met Gly Ser Leu Lys Ala

200 205 210tac aac acc tcc gga aag cac cgc cac acc ccg gaa att gcc cag aac 787Tyr Asn Thr Ser Gly Lys His Arg His Thr Pro Glu Ile Ala Gln Asn

215 220 225ctc ggc gaa gtc agc gac aag cca gtc aag gtg agc ttc acc cca gtg 835Leu Gly Glu Val Ser Asp Lys Pro Val Lys Val Ser Phe Thr Pro Val230 235 240 245ctt gca ccg tta cct cgc gaa ttc tca cca ctg caa ccg cac ctt 880Leu Ala Pro Leu Pro Arg Glu Phe Ser Pro Leu Gln Pro His Leu

250255260 tgaaagaagg cgttaccgca gaa 903<210>324<211>260<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>324Met Ile Met His Asn Val Tyr Gly Val Thr Met Thr Ile Lys Val Ala 151015 Ile Ala Gly Ala Ser Gly Tyr Ala Gly Gly Glu Ile Leu Arg Leu Leu

20 2530Leu Gly His Pro Ala Tyr Ala Ser Gly Glu Leu Glu Ile Gly Ala Leu

35 40 45Thr Ala Ala Ser Thr Ala Gly Ser Thr Leu Gly Glu Leu Met Pro His

50 55 60Ile Pro Gln Leu Ala Asp Arg Val Ile Gln Asp Thr Thr Ala Glu Thr 65 70 75 80Leu Ala Gly His Asp Val Val Phe Leu Gly Leu Pro His Gly Phe Ser

85 90 95Ala Glu Ile Ala Leu Gln Leu Gly Pro Asp Val Thr Val Ile Asp Cys

100 105 110Ala Ala Asp Phe Arg Leu Gln Asn Ala Ala Asp Trp Glu Lys Phe Tyr

115 120 125Gly Ser Glu His Gln Gly Thr Trp Pro Tyr Gly Ile Pro Glu Met Pro

130 135 140Gly His Arg Glu Ala Leu Arg Gly Ala Lys Arg Val Ala Val Pro Gly145 150 155 160Cys Phe Pro Thr Gly Ala Thr Leu Ala Leu Leu Pro Ala Val Gln Ala

165 170 175Gly Leu Ile Glu Pro Asp Val Ser Val Val Ser Ile Thr Gly Val Ser

180 185 190Gly Ala Gly Lys Lys Ala Ser Val Ala Leu Leu Gly Ser Glu Thr Met

195 200 205Gly Ser Leu Lys Ala Tyr Asn Thr Ser Gly Lys His Arg His Thr Pro

210 215 220Glu Ile Ala Gln Asn Leu Gly Glu Val Ser Asp Lys Pro Val Lys Val225 230 235 240Ser Phe Thr Pro Val Leu Ala Pro Leu Pro Arg Glu Phe Ser Pro Leu

245 250255Gln Pro His Leu

260<210>325<211>414<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (391)<223>RXA02154<400>325cccagaacct cggcgaagtc agcgacaagc cagtcaaggt gagcttcacc ccagtgcttg 60caccgttacc tcgcgaattc tcaccactgc aaccgcacct ttg aaa gaa ggc gtt 115

Leu Lys Glu Gly Val

1 5acc gca gaa cag gct cgc gca gta tat gaa gag ttc tat gca cag gaa 163Thr Ala Glu Gln Ala Arg Ala Val Tyr Glu Glu Phe Tyr Ala Gln Glu

10 15 20acc ttc gtg cat gtt ctt cca gaa ggt gca cag cca caa acc caa gca 211Thr Phe Val His Val Leu Pro Glu Gly Ala Gln Pro Gln Thr Gln Ala

25 30 35gtt ctt ggc tcc aac atg tgc cac gtg cag gta gaa att gat gag gaa 259Val Leu Gly Ser Asn Met Cys His Val Gln Val Glu Ile Asp Glu Glu

40 45 50gca ggc aaa gtc ctt gtt acc tcc gca atc gat aac ctc acc aag gga 307Ala Gly Lys Val Leu Val Thr Ser Ala Ile Asp Asn Leu Thr Lys Gly

55 60 65act gcc ggc gcc gct gtt cag tgc atg aac tta agc gtt ggt ttt gat 355Thr Ala Gly Ala Ala Val Gln Cys Met Asn Leu Ser Val Gly Phe Asp 70 75 80 85gag gca gca ggc ctg cca cag gtc ggc gtc gca cct taaagtagcg 401Glu Ala Ala Gly Leu Pro Gln Val Gly Val Ala Pro

9095 ccttaaagcg gcg 414<210>326<211>97<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>326Leu Lys Glu Gly Val Thr Ala Glu Gln Ala Arg Ala Val Tyr Glu Glu 151015 PheTyr Ala Gln Glu Thr Phe Val His Val Leu Pro Glu Gly Ala Gln

20 25 30Pro Gln Thr Gln Ala Val Leu Gly Ser Asn Met Cys His Val Gln Val

35 40 45Glu Ile Asp Glu Glu Ala Gly Lys Val Leu Val Thr Ser Ala Ile Asp

50 55 60Asn Leu Thr Lys Gly Thr Ala Gly Ala Ala Val Gln Cys Met Asn Leu 65 70 75 80Ser Val Gly Phe Asp Glu Ala Ala Gly Leu Pro Gln Val Gly Val Ala

859095 Pro<210>327<211>1296<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1273)<223>RXA02157<400>327<327gggtggaatt ggcacgatgg tgctgccgga tgtttttgat cgggagaatt atcctgaagg 60caccgttttt agaaaagacg acaaggatgg ggaactgtaa atg agc acg ctg gaa 115

Met Ser Thr Leu Glu

1 5act tgg cca cag gtc att att aat acg tac ggc acc cca cca gtt gag 163Thr Trp Pro Gln Val Ile Ile Asn Thr Tyr Gly Thr Pro Pro Val Glu

10 15 20ctg gtg tcc ggc aag ggc gca acc gtc act gat gac cag ggc aat gtc 211Leu Val Ser Gly Lys Gly Ala Thr Val Thr Asp Asp Gln Gly Asn Val

25 30 35tac atc gac ttg ctc gcg ggc atc gca gtc aac gcg ttg ggc cac gcc 259Tyr Ile Asp Leu Leu Ala Gly Ile Ala Val Asn Ala Leu Gly His Ala

40 45 50cac ccg gcg atc atc gag gcg gtc acc aac cag atc ggc caa ctt ggt 307His Pro Ala Ile Ile Glu Ala Val Thr Asn Gln Ile Gly Gln Leu Gly

55 60 65cac gtc tca aac ttg ttc gca tcc agg ccc gtc gtc gag gtc gcc gag 355His Val Ser Asn Leu Phe Ala Ser Arg Pro Val Val Glu Val Ala Glu 70 75 80 85gag ctc atc aag cgt ttt tcg ctt gac gac gcc acc ctc gcc gcg caa 403Glu Leu Ile Lys Arg Phe Ser Leu Asp Asp Ala Thr Leu Ala Ala Gln

90 95 100acc cgg gtt ttc ttc tgc aac tcg ggc gcc gaa gca aac gag gct gct 451Thr Arg Val Phe Phe Cys Asn Ser Gly Ala Glu Ala Asn Glu Ala Ala

105 110 115ttc aag att gca cgc ttg act ggt cgt tcc cgg att ctg gct gca gtt 499Phe Lys Ile Ala Arg Leu Thr Gly Arg Ser Arg Ile Leu Ala Ala Val

120 125 130cat ggt ttc cac ggc cgc acc atg ggt tcc ctc gcg ctg act ggc cag 547His Gly Phe His Gly Arg Thr Met Gly Ser Leu Ala Leu Thr Gly Gln

135 140 145cca gac aag cgt gaa gcg ttc ctg cca atg cca agc ggt gtg gag ttc 595Pro Asp Lys Arg Glu Ala Phe Leu Pro Met Pro Ser Gly Val Glu Phe150 155 160 165tac cct tac ggc gac acc gat tac ttg cgc aaa atg gta gaa acc aac 643Tyr Pro Tyr Gly Asp Thr Asp Tyr Leu Arg Lys Met Val Glu Thr Asn

170 175 180cca acg gat gtg gct gct atc ttc ctc gag cca atc cag ggt gaa acg 691Pro Thr Asp Val Ala Ala Ile Phe Leu Glu Pro Ile Gln Gly Glu Thr

185 190 195ggc gtt gtt cca gca cct gaa gga ttc ctc aag gca gtg cgc gag ctg 739Gly Val Val Pro Ala Pro Glu Gly Phe Leu Lys Ala Val Arg Glu Leu

200 205 210tgc gat gag tac ggc atc ttg atg atc acc gat gaa gtc cag act ggc 787Cys Asp Glu Tyr Gly Ile Leu Met Ile Thr Asp Glu Val Gln Thr Gly

215 220 225gtt ggc cgt acc ggc gat ttc ttt gca cat cag cac gat ggc gtt gtt 835Val Gly Arg Thr Gly Asp Phe Phe Ala His Gln His Asp Gly Val Val230 235 240 245ccc gat gtg gtg acc atg gcc aag gga ctt ggc ggc ggt ctt ccc atc 883Pro Asp Val Val Thr Met Ala Lys Gly Leu Gly Gly Gly Leu Pro Ile

250 255 260ggt gct tgt ttg gcc act ggc cgt gca gct gaa ttg atg acc cca ggc 931Gly Ala Cys Leu Ala Thr Gly Arg Ala Ala Glu Leu Met Thr Pro Gly

265 270 275aag cac ggc acc act ttc ggt ggc aac cca gtt gct tgt gca gct gcc 979Lys His Gly Thr Thr Phe Gly Gly Asn Pro Val Ala Cys Ala Ala Ala

280 285 290aag gca gtg ctg tct gtt gtc gat gac gct ttc tgc gca gaa gtt gcc 1027Lys Ala Val Leu Ser Val Val Asp Asp Ala Phe Cys Ala Glu Val Ala

295 300 305cgc aag ggc gag ctg ttc aag gaa ctt ctt gcc aag gtt gac ggc gtt 1075Arg Lys Gly Glu Leu Phe Lys Glu Leu Leu Ala Lys Val Asp Gly Val310 315 320 325gta gac gtc cgt ggc agg ggc ttg atg ttg ggc gtg gtg ctg gag cgc 1123Val Asp Val Arg Gly Arg Gly Leu Met Leu Gly Val Val Leu Glu Arg

330 335 340gac gtc gca aag caa gct gtt ctt gat ggt ttt aag cac ggc gtt att 1171Asp Val Ala Lys Gln Ala Val Leu Asp Gly Phe Lys His Gly Val Ile

345 350 355ttg aat gca ccg gcg gac aac att atc cgt ttg acc ccg ccg ctg gtg 1219Leu Asn Ala Pro Ala Asp Asn Ile Ile Arg Leu Thr Pro Pro Leu Val

360 365 370atc acc gac gaa gaa atc gca gac gca gtc aag gct att gcc gag aca 1267Ile Thr Asp Glu Glu Ile Ala Asp Ala Val Lys Ala Ile Ala Glu Thr

375380385 atc gca taaaggactc aaacttatga ctt 1296Ile Ala390<210>328<211>391<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>328Met Ser Thr Leu Glu Thr Trp Pro Gln Val Ile Ile Asn Thr Tyr Gly 151015 Thr Pro Pro Val Glu Leu Val Ser Gly Lys Gly Ala Thr Val Thr Asp

20 25 30Asp Gln Gly Asn Val Tyr Ile Asp Leu Leu Ala Gly Ile Ala Val Asn

35 40 45Ala Leu Gly His Ala His Pro Ala Ile Ile Glu Ala Val Thr Asn Gln

50 55 60Ile Gly Gln Leu Gly His Val Ser Asn Leu Phe Ala Ser Arg Pro Val 65 70 75 80Val Glu Val Ala Glu Glu Leu Ile Lys Arg Phe Ser Leu Asp Asp Ala

85 90 95Thr Leu Ala Ala Gln Thr Arg Val Phe Phe Cys Asn Ser Gly Ala Glu

100 105 110Ala Asn Glu Ala Ala Phe Lys Ile Ala Arg Leu Thr Gly Arg Ser Arg

115 120 125Ile Leu Ala Ala Val His Gly Phe His Gly Arg Thr Met Gly Ser Leu

130 135 140Ala Leu Thr Gly Gln Pro Asp Lys Arg Glu Ala Phe Leu Pro Met Pro145 150 155 160Ser Gly Val Glu Phe Tyr Pro Tyr Gly Asp Thr Asp Tyr Leu Arg Lys

165 170 175Met Val Glu Thr Asn Pro Thr Asp Val Ala Ala Ile Phe Leu Glu Pro

180 185 190Ile Gln Gly Glu Thr Gly Val Val Pro Ala Pro Glu Gly Phe Leu Lys

195 200 205Ala Val Arg Glu Leu Cys Asp Glu Tyr Gly Ile Leu Met Ile Thr Asp

210 215 220Glu Val Gln Thr Gly Val Gly Arg Thr Gly Asp Phe Phe Ala His Gln225 230 235 240His Asp Gly Val Val Pro Asp Val Val Thr Met Ala Lys Gly Leu Gly

245 250 255Gly Gly Leu Pro Ile Gly Ala Cys Leu Ala Thr Gly Arg Ala Ala Glu

260 265 270Leu Met Thr Pro Gly Lys His Gly Thr Thr Phe Gly Gly Asn Pro Val

275 280 285Ala Cys Ala Ala Ala Lys Ala Val Leu Ser Val Val Asp Asp Ala Phe

290 295 300Cys Ala Glu Val Ala Arg Lys Gly Glu Leu Phe Lys Glu Leu Leu Ala305 310 315 320Lys Val Asp Gly Val Val Asp Val Arg Gly Arg Gly Leu Met Leu Gly

325 330 335Val Val Leu Glu Arg Asp Val Ala Lys Gln Ala Val Leu Asp Gly Phe

340 345 350Lys His Gly Val Ile Leu Asn Ala Pro Ala Asp Asn Ile Ile Arg Leu

355 360 365Thr Pro Pro Leu Val Ile Thr Asp Glu Glu Ile Ala Asp Ala Val Lys

370375380 Ala Ile Ala Glu Thr Ile Ala 385390<210>329<211>1491<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1468)<223>RXS02970<400>329aaccgacaaa acagccgttc acgtgctaaa gcagctcggc ttgatctagggtgaggtgag 60ttatttaaag acttcataat attttgggga gtgaactggt ttg gca ttg aag ggt 115

Leu Ala Leu Lys Gly

1 5tac acc aac ttt gac ggt gaa ttc atc gaa ttc gga tct gtg caa gca 163Tyr Thr Asn Phe Asp Gly Glu Phe Ile Glu Phe Gly Ser Val Gln Ala

10 15 20aaa gaa gag gaa aaa cgg gca ttc gac aac gat cgc gcg cac gtt ttc 211Lys Glu Glu Glu Lys Arg Ala Phe Asp Asn Asp Arg Ala His Val Phe

25 30 35cac tcc tgg tcc gcg cag gac aaa atc agc ccc aaa gta tgg gca gct 259His Ser Trp Ser Ala Gln Asp Lys Ile Ser Pro Lys Val Trp Ala Ala

40 45 50gcc gaa ggt tcc acg ctg tac gac ttc gac ggc aac gcc ttc atc gac 307Ala Glu Gly Ser Thr Leu Tyr Asp Phe Asp Gly Asn Ala Phe Ile Asp

55 60 65atg ggt tcc caa ctt gtc tcg gca aac tta ggc cac aac aac cct cga 355Met Gly Ser Gln Leu Val Ser Ala Asn Leu Gly His Asn Asn Pro Arg 70 75 80 85tta gtt gag gcg atc cag cgc caa gca gcc cgg ttg acc aac atc aac 403Leu Val Glu Ala Ile Gln Arg Gln Ala Ala Arg Leu Thr Asn Ile Asn

90 95 100ccg gcc ttc ggc aat gat gtg cgc tct gat gtt gct gca aag atc gtg 451Pro Ala Phe Gly Asn Asp Val Arg Ser Asp Val Ala Ala Lys Ile Val

105 110 115tcg atg gcc cgt ggc gaa ttc tcc cac gtg ttt ttc acc aac ggc ggc 499Ser Met Ala Arg Gly Glu Phe Ser His Val Phe Phe Thr Asn Gly Gly

120 125 130gcc gac gcc atc gag cac tcc atccgc atg gct cgc ctg cac acc gga 547Ala Asp Ala Ile Glu His Ser Ile Arg Met Ala Arg Leu His Thr Gly

135 140 145cgc aac aaa att ctg tcc gca tac cgc agc tac cac ggc gca acc gga 595Arg Asn Lys Ile Leu Ser Ala Tyr Arg Ser Tyr His Gly Ala Thr Gly150 155 160 165tcc gcg atg atg ctc acc ggc gaa cac cgc cgc ctg ggc aac ccc acc 643Ser Ala Met Met Leu Thr Gly Glu His Arg Arg Leu Gly Asn Pro Thr

170 175 180acc gac cca gat atc tac cac ttc tgg gca cca ttc ctg cac cac tcc 691Thr Asp Pro Asp Ile Tyr His Phe Trp Ala Pro Phe Leu His His Ser

185 190 195tca ttc ttt gcc acc acc caa gaa gaa gaa tgc gaa cgc gca ctc aag 739Ser Phe Phe Ala Thr Thr Gln Glu Glu Glu Cys Glu Arg Ala Leu Lys

200 205 210cac ttg gaa gat gtc atc gcg ttt gaa ggt gct ggc atg atc gca gcg 787His Leu Glu Asp Val Ile Ala Phe Glu Gly Ala Gly Met Ile Ala Ala

215 220 225atc gtc ctg gag cca gtg gtg gga tca tca gga atc atc ctg cca cca 835Ile Val Leu Glu Pro Val Val Gly Ser Ser Gly Ile Ile Leu Pro Pro230 235 240 245gca ggt tac tta aat ggc gtg cgc gaa ctt tgc aac aag cac ggc atc 883Ala Gly Tyr Leu Asn Gly Val Arg Glu Leu Cys Asn Lys His Gly Ile

250 255 260ctc ttc atc gcc gac gaa gtc atg gtc gga ttc gga cgc acc gga aaa 931Leu Phe Ile Ala Asp Glu Val Met Val Gly Phe Gly Arg Thr Gly Lys

265 270 275ctg ttt gct tac gag cat gct ggc gac gat ttc cag cca gac atg atc 979Leu Phe Ala Tyr Glu His Ala Gly Asp Asp Phe Gln Pro Asp Met Ile

280 285 290acc ttc gcc aag ggt gtt aac gca ggt tac gcc cca ctc ggt ggc atc 1027Thr Phe Ala Lys Gly Val Asn Ala Gly Tyr Ala Pro Leu Gly Gly Ile

295 300 305gtg atg acc caa tca atc cgc gat acc ttc gga tca gag gca tac tcc 1075Val Met Thr Gln Ser Ile Arg Asp Thr Phe Gly Ser Glu Ala Tyr Ser310 315 320 325ggc gga ctc acc tac tcc gga cac cca ctt gca gta gca ccc gcc aag 1123Gly Gly Leu Thr Tyr Ser Gly His Pro Leu Ala Val Ala Pro Ala Lys

330 335 340gca gcg ctg gag att tac gcg gaa gga gag atc att cca cgc gta gct 1171Ala Ala Leu Glu Ile Tyr Ala Glu Gly Glu Ile Ile Pro Arg Val Ala

345 350 355cga ctt ggc gct gaa ctg atc gaa cct cgc ctt cgt gaa cta gcg gaa 1219Arg Leu Gly Ala Glu Leu Ile Glu Pro Arg Leu Arg Glu Leu Ala Glu

360 365 370gaa aac gta gcg atc gct gac gtg cgg ggc atc gga ttc ttc tgg gca 1267Glu Asn Val Ala Ile Ala Asp Val Arg Gly Ile Gly Phe Phe Trp Ala

375 380 385gtg gag ttc aat gca gac gcc act gcc atg gct gcc ggt gct gca gaa 1315Val Glu Phe Asn Ala Asp Ala Thr Ala Met Ala Ala Gly Ala Ala Glu390 395 400 405ttc aag gaa cgc ggc gtg tgg ccg atg atc tcc ggc aac cga ttc cac 1363Phe Lys Glu Arg Gly Val Trp Pro Met Ile Ser Gly Asn Arg Phe His

410 415 420atc gcg ccg ccg ctg acc acc act gat gac gaa ttg gta gca ctg ctg 1411Ile Ala Pro Pro Leu Thr Thr Thr Asp Asp Glu Leu Val Ala Leu Leu

425 430 435gac gcg gtg gaa gct gca gcc caagct gtc gag ctg acc ttc gct ggg 1459Asp Ala Val Glu Ala Ala Ala Gln Ala Val Glu Leu Thr Phe Ala Gly

440 445 450gcg ttg ttc taagttttct agataacaag gcc 1491Ala Leu Phe

455<210>330<211>456<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>330Leu Ala Leu Lys Gly Tyr Thr Asn Phe Asp Gly Glu Phe Ile Glu Phe 151015 Gly Ser Val Gln Ala Lys Glu Glu Glu Lys Arg Ala Phe Asp Asn Asp

20 25 30Arg Ala His Val Phe His Ser Trp Ser Ala Gln Asp Lys Ile Ser Pro

35 40 45Lys Val Trp Ala Ala Ala Glu Gly Ser Thr Leu Tyr Asp Phe Asp Gly

50 55 60Asn Ala Phe Ile Asp Met Gly Ser Gln Leu Val Ser Ala Asn Leu Gly 65 70 75 80His Asn Asn Pro Arg Leu Val Glu Ala Ile Gln Arg Gln Ala Ala Arg

85 90 95Leu Thr Asn Ile Asn Pro Ala Phe Gly Asn Asp Val Arg Ser Asp Val

100 105 110Ala Ala Lys Ile Val Ser Met Ala Arg Gly Glu Phe Ser His Val Phe

115 120 125Phe Thr Asn Gly Gly Ala Asp Ala Ile Glu His Ser Ile Arg Met Ala

130 135 140Arg Leu His Thr Gly Arg Asn Lys Ile Leu Ser Ala Tyr Arg Ser Tyr145 150 155 160His Gly Ala Thr Gly Ser Ala Met Met Leu Thr Gly Glu His Arg Arg

165 170 175Leu Gly Asn Pro Thr Thr Asp Pro Asp Ile Tyr His Phe Trp Ala Pro

180 185 190Phe Leu His His Ser Ser Phe Phe Ala Thr Thr Gln Glu Glu Glu Cys

195 200 205Glu Arg Ala Leu Lys His Leu Glu Asp Val Ile Ala Phe Glu Gly Ala

210 215 220Gly Met Ile Ala Ala Ile Val Leu Glu Pro Val Val Gly Ser Ser Gly225 230 235 240Ile Ile Leu Pro Pro Ala Gly Tyr Leu Asn Gly Val Arg Glu Leu Cys

245 250 255Asn Lys His Gly Ile Leu Phe Ile Ala Asp Glu Val Met Val Gly Phe

260 265 270Gly Arg Thr Gly Lys Leu Phe Ala Tyr Glu His Ala Gly Asp Asp Phe

275 280 285Gln Pro Asp Met Ile Thr Phe Ala Lys Gly Val Asn Ala Gly Tyr Ala

290 295 300Pro Leu Gly Gly Ile Val Met Thr Gln Ser Ile Arg Asp Thr Phe Gly305 310 315 320Ser Glu Ala Tyr Ser Gly Gly Leu Thr Tyr Ser Gly His Pro Leu Ala

325 330 335Val Ala Pro Ala Lys Ala Ala Leu Glu Ile Tyr Ala Glu Gly Glu Ile

340 345 350Ile Pro Arg Val Ala Arg Leu Gly Ala Glu Leu Ile Glu Pro Arg Leu

355 360 365Arg Glu Leu Ala Glu Glu Asn Val Ala Ile Ala Asp Val Arg Gly Ile

370 375 380Gly Phe Phe Trp Ala Val Glu Phe Asn Ala Asp Ala Thr Ala Met Ala385 390 395 400Ala Gly Ala Ala Glu Phe Lys Glu Arg Gly Val Trp Pro Met Ile Ser

405 410 415Gly Asn Arg Phe His Ile Ala Pro Pro Leu Thr Thr Thr Asp Asp Glu

420 425 430Leu Val Ala Leu Leu Asp Ala Val Glu Ala Ala Ala Gln Ala Val Glu

435 440 445Leu Thr Phe Ala Gly Ala Leu Phe

450455<210>331<211>1330<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1330)<223>FRXA01009<400>331aaccgacaaa acagccgttc acgtgctaaa gcagctcggc ttgatctagg gtgaggtgag 60ttatttaaag acttcataat attttgggga gtgaactggt ttg gca ttg aag ggt 115

Leu Ala Leu Lys Gly

1 5tac acc aac ttt gac ggt gaa ttc atc gaa ttc gga tct gtg caa gca 163Tyr Thr Asn Phe Asp Gly Glu Phe Ile Glu Phe Gly Ser Val Gln Ala

10 15 20aaa gaa gag gaa aaa cgg gca ttc gac aac gat cgc gcg cac gtt ttc 211Lys Glu Glu Glu Lys Arg Ala Phe Asp Asn Asp Arg Ala His Val Phe

25 30 35cac tcc tgg tcc gcg cag gac aaa atc agc ccc aaa gta tgg gca gct 259His Ser Trp Ser Ala Gln Asp Lys Ile Ser Pro Lys Val Trp Ala Ala

40 45 50gcc gaa ggt tcc acg ctg tac gac ttc gac ggc aac gcc ttc atc gac 307Ala Glu Gly Ser Thr Leu Tyr Asp Phe Asp Gly Asn Ala Phe Ile Asp

55 60 65atg ggt tcc caa ctt gtc tcg gca aac tta ggc cac aac aac cct cga 355Met Gly Ser Gln Leu Val Ser Ala Asn Leu Gly His Asn Asn Pro Arg 70 75 80 85tta gttgag gcg atc cag cgc caa gca gcc cgg ttg acc aac atc aac 403Leu Val Glu Ala Ile Gln Arg Gln Ala Ala Arg Leu Thr Asn Ile Asn

90 95 100ccg gcc ttc ggc aat gat gtg cgc tct gat gtt gct gca aag atc gtg 451Pro Ala Phe Gly Asn Asp Val Arg Ser Asp Val Ala Ala Lys Ile Val

105 110 115tcg atg gcc cgt ggc gaa ttc tcc cac gtg ttt ttc acc aac ggc ggc 499Ser Met Ala Arg Gly Glu Phe Ser His Val Phe Phe Thr Asn Gly Gly

120 125 130gcc gac gcc atc gag cac tcc atc cgc atg gct cgc ctg cac acc gga 547Ala Asp Ala Ile Glu His Ser Ile Arg Met Ala Arg Leu His Thr Gly

135 140 145cgc aac aaa att ctg tcc gca tac cgc agc tac cac ggc gca acc gga 595Arg Asn Lys Ile Leu Ser Ala Tyr Arg Ser Tyr His Gly Ala Thr Gly150 155 160 165tcc gcg atg atg ctc acc ggc gaa cac cgc cgc ctg ggc aac ccc acc 643Ser Ala Met Met Leu Thr Gly Glu His Arg Arg Leu Gly Asn Pro Thr

170 175 180acc gac cca gat atc tac cac ttc tgg gca cca ttc ctg cac cac tcc 691Thr Asp Pro Asp Ile Tyr His Phe Trp Ala Pro Phe Leu His His Ser

185 190 195tca ttc ttt gcc acc acc caa gaa gaa gaa tgc gaa cgc gca ctc aag 739Ser Phe Phe Ala Thr Thr Gln Glu Glu Glu Cys Glu Arg Ala Leu Lys

200 205 210cac ttg gaa gat gtc atc gcg ttt gaa ggt gct ggc atg atc gca gcg 787His Leu Glu Asp Val Ile Ala Phe Glu Gly Ala Gly Met Ile Ala Ala

215 220 225atc gtc ctg gag cca gtg gtg gga tca tca gga atc atc ctg cca cca 835Ile Val Leu Glu Pro Val Val GlySer Ser Gly Ile Ile Leu Pro Pro230 235 240 245gca ggt tac tta aat ggc gtg cgc gaa ctt tgc aac aag cac ggc atc 883Ala Gly Tyr Leu Asn Gly Val Arg Glu Leu Cys Asn Lys His Gly Ile

250 255 260ctc ttc atc gcc gac gaa gtc atg gtc gga ttc gga cgc acc gga aaa 931Leu Phe Ile Ala Asp Glu Val Met Val Gly Phe Gly Arg Thr Gly Lys

265 270 275ctg ttt gct tac gag cat gct ggc gac gat ttc cag cca gac atg atc 979Leu Phe Ala Tyr Glu His Ala Gly Asp Asp Phe Gln Pro Asp Met Ile

280 285 290acc ttc gcc aag ggt gtt aac gca ggt tac gcc cca ctc ggt ggc atc 1027Thr Phe Ala Lys Gly Val Asn Ala Gly Tyr Ala Pro Leu Gly Gly Ile

295 300 305gtg atg acc caa tca atc cgc gat acc ttc gga tca gag gca tac tcc 1075Val Met Thr Gln Ser Ile Arg Asp Thr Phe Gly Ser Glu Ala Tyr Ser310 315 320 325ggc gga ctc acc tac tcc gga cac cca ctt gca gta gca ccc gcc aag 1123Gly Gly Leu Thr Tyr Ser Gly His Pro Leu Ala Val Ala Pro Ala Lys

330 335 340gca gcg ctg gag att tac gcg gaa gga gag atc att cca cgc gta gct 1171Ala Ala Leu Glu Ile Tyr Ala Glu Gly Glu Ile Ile Pro Arg Val Ala

345 350 355

cga ctt ggc gct gaa ctg atc gaa cct cgc ctt cgt gaa cta gcg gaa 1219Arg Leu Gly Ala Glu Leu Ile Glu Pro Arg Leu Arg Glu Leu Ala Glu

360 365 370gaa aac gta gcg atc gct gac gtg cgg ggc atc gga ttc ttc tgg gca 1267Glu Asn Val Ala Ile Ala Asp Val Arg Gly Ile Gly Phe Phe Trp Ala

375 380 385gtg gag ttc aat gca gac gcc act gcc atg gct gcc ggt gct gca gaa 1315Val Glu Phe Asn Ala Asp Ala Thr Ala Met Ala Ala Gly Ala Ala Glu390 395 400 405ttc aag gaa cgc ggc 1330Phe Lys Glu Arg Gly

410<210>332<211>410<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>332Leu Ala Leu Lys Gly Tyr Thr Asn Phe Asp Gly Glu Phe Ile Glu Phe 151015 Gly Ser Val Gln Ala Lys Glu Glu Glu Lys Arg Ala Phe Asp Asn Asp

20 25 30Arg Ala His Val Phe His Ser Trp Ser Ala Gln Asp Lys Ile Ser Pro

35 40 45Lys Val Trp Ala Ala Ala Glu Gly Ser Thr Leu Tyr Asp Phe Asp Gly

50 55 60Asn Ala Phe Ile Asp Met Gly Ser Gln Leu Val Ser Ala Asn Leu Gly 65 70 75 80His Asn Asn Pro Arg Leu Val Glu Ala Ile Gln Arg Gln Ala Ala Arg

85 90 95Leu Thr Asn Ile Asn Pro Ala Phe Gly Asn Asp Val Arg Ser Asp Val

100 105 110Ala Ala Lys Ile Val Ser Met Ala Arg Gly Glu Phe Ser His Val Phe

115 120 125Phe Thr Asn Gly Gly Ala Asp Ala Ile Glu His Ser Ile Arg Met Ala

130 135 140Arg Leu His Thr Gly Arg Asn Lys Ile Leu Ser Ala Tyr Arg Ser Tyr145 150 155 160His Gly Ala Thr Gly Ser Ala Met Met Leu Thr Gly Glu His Arg Arg

165 170 175Leu Gly AsnPro Thr Thr Asp Pro Asp Ile Tyr His Phe Trp Ala Pro

180 185 190Phe Leu His His Ser Ser Phe Phe Ala Thr Thr Gln Glu Glu Glu Cys

195 200 205Glu Arg Ala Leu Lys His Leu Glu Asp Val Ile Ala Phe Glu Gly Ala

210 215 220Gly Met Ile Ala Ala Ile Val Leu Glu Pro Val Val Gly Ser Ser Gly225 230 235 240Ile Ile Leu Pro Pro Ala Gly Tyr Leu Asn Gly Val Arg Glu Leu Cys

245 250 255Asn Lys His Gly Ile Leu Phe Ile Ala Asp Glu Val Met Val Gly Phe

260 265 270Gly Arg Thr Gly Lys Leu Phe Ala Tyr Glu His Ala Gly Asp Asp Phe

275 280 285Gln Pro Asp Met Ile Thr Phe Ala Lys Gly Val Asn Ala Gly Tyr Ala

290 295 300Pro Leu Gly Gly Ile Val Met Thr Gln Ser Ile Arg Asp Thr Phe Gly305 310 315 320Ser Glu Ala Tyr Ser Gly Gly Leu Thr Tyr Ser Gly His Pro Leu Ala

325 330 335Val Ala Pro Ala Lys Ala Ala Leu Glu Ile Tyr Ala Glu Gly Glu Ile

340 345 350Ile Pro Arg Val Ala Arg Leu Gly Ala Glu Leu Ile Glu Pro Arg Leu

355 360 365Arg Glu Leu Ala Glu Glu Asn Val Ala Ile Ala Asp Val Arg Gly Ile

370 375 380Gly Phe Phe Trp Ala Val Glu Phe Asn Ala Asp Ala Thr Ala Met Ala385 390 395 400Ala Gly Ala Ala Glu Phe LysGlu Arg Gly

405410<210>333<211>1080<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1057)<223>RXA02158<400>333aacattatcc gtttgacccc gccgctggtg atcaccgacg aagaaatcgc agacgcagtc 60aaggctattg ccgagacaat cgcataaagg actcaaactt atg act tca caa cca 115

Met Thr Ser Gln Pro

1 5cag gtt cgc cat ttt ctg gct gat gat gat ctc acc cct gca gag cag 163Gln Val Arg His Phe Leu Ala Asp Asp Asp Leu Thr Pro Ala Glu Gln

10 15 20gca gag gtt ttg acc cta gcc gca aag ctc aag gca gcg ccg ttt tcg 211Ala Glu Val Leu Thr Leu Ala Ala Lys Leu Lys Ala Ala Pro Phe Ser

25 30 35gag cgt cca ctc gag gga cca aag tcc gtt gca gtt ctt ttt gat aag 259Glu Arg Pro Leu Glu Gly Pro Lys Ser Val Ala Val Leu Phe Asp Lys

40 45 50act tca act cgt act cgc ttc tcc ttc gac gcg ggc atc gct cat ttg 307Thr Ser Thr Arg Thr Arg Phe Ser Phe Asp Ala Gly Ile Ala His Leu

55 60 65ggt gga cac gcc atc gtc gtg gat tcc ggt agc tca cag atg ggt aag 355Gly Gly His Ala Ile Val Val Asp Ser Gly Ser Ser Gln Met Gly Lys 70 75 80 85ggc gag tcc ctg cag gac acc gca gct gta ttg tcc cgc tac gtg gaa 403Gly Glu Ser Leu Gln Asp Thr Ala Ala Val Leu Ser Arg Tyr Val Glu

90 95 100gca att gtg tgg cgc acc tac gca cac agc aat ttc cac gcc atg gcg 451Ala Ile Val Trp Arg Thr Tyr Ala His Ser Asn Phe His Ala Met Ala

105 110 115gag acg tcc act gtg ccg ctg gtg aac tcc ttg tcc gat gat ctg cac 499Glu Thr Ser Thr Val Pro Leu Val Asn Ser Leu Ser Asp Asp Leu His

120 125 130cca tgc cag att ctg gct gat ctg cag act atc gtg gaa aac ctc agc 547Pro Cys Gln Ile Leu Ala Asp Leu Gln Thr Ile Val Glu Asn Leu Ser

135 140 145cct gaa gaa ggc cca gca ggc ctt aag ggt aag aag gct gtg tac ctg 595Pro Glu Glu Gly Pro Ala Gly Leu Lys Gly Lys Lys Ala Val Tyr Leu150 155 160 165ggc gat ggc gac aac aac atg gcc aac tcc tac atg att ggc ttt gcc 643Gly Asp Gly Asp Asn Asn Met Ala Asn Ser Tyr Met Ile Gly Phe Ala

170 175 180acc gcg ggc atg gat att tcc atc atc gct cct gaa ggg ttc cag cct 691Thr Ala Gly Met Asp Ile Ser Ile Ile Ala Pro Glu Gly Phe Gln Pro

185 190 195cgt gcg gaa ttc gtg gag cgc gcg gaa aag cgt ggc cag gaa acc ggc 739Arg Ala Glu Phe Val Glu Arg Ala Glu Lys Arg Gly Gln Glu Thr Gly

200 205 210gcg aag gtt gtt gtc acc gac agc ctc gac gag gtt gcc ggc gcc gat 787Ala Lys Val Val Val Thr Asp Ser Leu Asp Glu Val Ala Gly Ala Asp

215 220 225gtt gtc atc acc gat acc tgg gta tcc atg ggt atg gaa aac gac ggc 835Val Val Ile Thr Asp Thr Trp Val Ser Met Gly Met Glu Asn Asp Gly230 235 240 245atc gat cgc acc aca cct ttc gtt cct tac cag gtc aac gat gag gtc 883Ile Asp Arg Thr Thr Pro Phe Val Pro Tyr Gln Val Asn Asp Glu Val

250 255 260atg gcg aaa gct aac gac ggc gcc atc ttc ctg cac tgcctt cct gcc 931Met Ala Lys Ala Asn Asp Gly Ala Ile Phe Leu His Cys Leu Pro Ala

265 270 275tac cgt ggc aaa gaa gtg gca gcc tcc gtg att gat gga cca gcg tcc 979Tyr Arg Gly Lys Glu Val Ala Ala Ser Val Ile Asp Gly Pro Ala Ser

280 285 290aaa gtt ttc gat gaa gca gaa aac cgc ctc cac gct cag aaa gca ctg 1027Lys Val Phe Asp Glu Ala Glu Asn Arg Leu His Ala Gln Lys Ala Leu

295300305 ctg gtg tgg ctg ctg gcc aac cag ccg agg taagacatgt cccttggctc 1077Leu Val Trp Leu Leu Ala Asn Gln Pro Arg 310315 aac 1080<210>334<211>319<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>334Met Thr Ser Gln Pro Gln Val Arg His Phe Leu Ala Asp Asp Asp Leu 151015 Thr Pro Ala Glu Gln Ala Glu Val Leu Thr Leu Ala Ala Lys Leu Lys

20 25 30Ala Ala Pro Phe Ser Glu Arg Pro Leu Glu Gly Pro Lys Ser Val Ala

35 40 45Val Leu Phe Asp Lys Thr Ser Thr Arg Thr Arg Phe Set Phe Asp Ala

50 55 60Gly Ile Ala His Leu Gly Gly His Ala Ile Val Val Asp Ser Gly Ser 65 70 75 80Ser Gln Met Gly Lys Gly Glu Ser Leu Gln Asp Thr Ala Ala Val Leu

85 90 95Ser Arg Tyr Val Glu Ala Ile Val Trp Arg Thr Tyr Ala His Ser Asn

100 105 110Phe His Ala Met Ala Glu Thr Ser Thr Val Pro Leu Val Asn Ser Leu

115 120 125Ser Asp Asp Leu His Pro Cys Gln Ile Leu Ala Asp Leu Gln Thr Ile

130 135140Val Glu Asn Leu Ser Pro Glu Glu Gly Pro Ala Gly Leu Lys Gly Lys145 150 155 160Lys Ala Val Tyr Leu Gly Asp Gly Asp Asn Asn Met Ala Asn Ser Tyr

165 170 175Met Ile Gly Phe Ala Thr Ala Gly Met Asp Ile Ser Ile Ile Ala Pro

180 185 190Glu Gly Phe Gln Pro Arg Ala Glu Phe Val Glu Arg Ala Glu Lys Arg

195 200 205Gly Gln Glu Thr Gly Ala Lys Val Val Val Thr Asp Ser Leu Asp Glu

210 215 220Val Ala Gly Ala Asp Val Val Ile Thr Asp Thr Trp Val Ser Met Gly225 230 235 240Met Glu Asn Asp Gly Ile Asp Arg Thr Thr Pro Phe Val Pro Tyr Gln

245 250 255Val Asn Asp Glu Val Met Ala Lys Ala Asn Asp Gly Ala Ile Phe Leu

260 265 270His Cys Leu Pro Ala Tyr Arg Gly Lys Glu Val Ala Ala Ser Val Ile

275 280 285Asp Gly Pro Ala Ser Lys Val Phe Asp Glu Ala Glu Asn Arg Leu His

290295300 Ala Gln Lys Ala Leu Leu Val Trp Leu Leu Ala Asn Gln Pro Arg 305310315<210>335<211>1326<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1303)<223>RXA02160<400>335ttttcgagga ataccaaccc tttcaacaca ataattttct ttaaacatcc ttgctgtcca 60ccacggctgg caaggaactt aaaatgaagg agcacacctc atg act aac cgc atc 115

Met Thr Asn Arg Ile

1 5gtt ctt gca tac tcc ggc ggt ctg gac acc act gtg gca att cca tac 163Val Leu Ala Tyr Ser Gly Gly Leu Asp Thr Thr Val Ala Ile Pro Tyr

10 15 20ctg aag aag atg att gat ggt gaa gtc atc gca gtt tcc ctc gac ctg 211Leu Lys Lys Met Ile Asp Gly Glu Val Ile Ala Val Ser Leu Asp Leu

25 30 35ggc cag ggt gga gag aac atg gac aac gtt cgc cag cgt gca ttg gat 259Gly Gln Gly Gly Glu Asn Met Asp Asn Val Arg Gln Arg Ala Leu Asp

40 45 50gcc ggt gca gct gag tcc atc gtt gtt gat gca aag gat gag ttc gct 307Ala Gly Ala Ala Glu Ser Ile Val Val Asp Ala Lys Asp Glu Phe Ala

55 60 65gag gag tac tgc ctg cca acc atc aag gca aac ggc atg tac atg aag 355Glu Glu Tyr Cys Leu Pro Thr Ile Lys Ala Asn Gly Met Tyr Met Lys 70 75 80 85cag tac cca ctg gtt tct gca atc tcc cgc cca ctg atc gtc aag cac 403Gln Tyr Pro Leu Val Ser Ala Ile Ser Arg Pro Leu Ile Val Lys His

90 95 100ctc gtt gag gct ggc aag cag ttc aac ggt acc cac gtt gca cac ggc 451Leu Val Glu Ala Gly Lys Gln Phe Asn Gly Thr His Val Ala His Gly

105 110 115tgc act ggt aag ggc aac gac cag gtt cgt ttc gag gtc ggc ttc atg 499Cys Thr Gly Lys Gly Asn Asp Gln Val Arg Phe Glu Val Gly Phe Met

120 125 130gac acc gat cca aac ctg gag atc att gca cct gct cgt gac ttc gca 547Asp Thr Asp Pro Asn Leu Glu Ile Ile Ala Pro Ala Arg Asp Phe Ala

135 140 145tgg acc cgc gac aag gct atc gcc ttc gcc gag gag aac aac gtt cca 595Trp Thr Arg Asp Lys Ala Ile Ala Phe Ala Glu Glu Asn Asn Val Pro150 155 160 165atc gag cag tcc gtg aag tcc cca ttc tcc atc gac cag aac gtc tgg 643Ile Glu Gln Ser Val Lys Ser Pro Phe Ser Ile Asp Gln Asn Val Trp

170 175 180ggc cgc gct att gag acc ggt tac ctg gaa gat ctg tgg aat gct cca 691Gly Arg Ala Ile Glu Thr Gly Tyr Leu Glu Asp Leu Trp Asn Ala Pro

185 190 195acc aag gac atc tac gca tac acc gag gat cca gct ctg ggt aac gct 739Thr Lys Asp Ile Tyr Ala Tyr Thr Glu Asp Pro Ala Leu Gly Asn Ala

200 205 210cca gat gag gtc atc atc tcc ttc gag ggt ggc aag cca gtc tcc atc 787Pro Asp Glu Val Ile Ile Ser Phe Glu Gly Gly Lys Pro Val Ser Ile

215 220 225gat ggc cgt cca gtc tcc gta ctg cag gct att gaa gag ctg aac cgt 835Asp Gly Arg Pro Val Ser Val Leu Gln Ala Ile Glu Glu Leu Asn Arg230 235 240 245cgt gca ggc gca cag ggc gtt ggc cgc ctt gac atg gtt gag gac cgt 883Arg Ala Gly Ala Gln Gly Val Gly Arg Leu Asp Met Val Glu Asp Arg

250 255 260ctc gtg ggc atc aag tcc cgc gaa atc tac gaa gca cca ggc gca atc 931Leu Val Gly Ile Lys Ser Arg Glu Ile Tyr Glu Ala Pro Gly Ala Ile

265 270 275gca ctg att aag gct cac gag gct ttg gaa gat gtc acc atc gag cgc 979Ala Leu Ile Lys Ala His Glu Ala Leu Glu Asp Val Thr Ile Glu Arg

280 285 290gaa ctg gct cgc tac aag cgc ggc gtt gac gca cgt tgg gct gag gaa 1027Glu Leu Ala Arg Tyr Lys Arg Gly Val Asp Ala Arg Trp Ala Glu Glu

295 300305gta tac gac ggc ctg tgg ttc gga cct ctg aag cgc tcc ctg gac gcg 1075Val Tyr Asp Gly Leu Trp Phe Gly Pro Leu Lys Arg Ser Leu Asp Ala310 315 320 325ttc att gat tcc acc cag gag cac gtc acc ggc gat atc cgc atg gtt 1123Phe Ile Asp Ser Thr Gln Glu His Val Thr Gly Asp Ile Arg Met Val

330 335 340ctg cac gca ggt tcc atc acc atc aat ggt cgt cgt tcc agc cac tcc 1171Leu His Ala Gly Ser Ile Thr Ile Asn Gly Arg Arg Ser Ser His Ser

345 350 355ctg tac gac ttc aac ctg gct acc tac gac acc ggc gac acc ttc gac 1219Leu Tyr Asp Phe Asn Leu Ala Thr Tyr Asp Thr Gly Asp Thr Phe Asp

360 365 370cag acc ctg gct aag ggc ttt gtc cag ctg cac ggt ctg tcc tcc aag 1267Gln Thr Leu Ala Lys Gly Phe Val Gln Leu His Gly Leu Ser Ser Lys

375380385 atc gct aac aag cgc gat cgc gaa gct ggc aac aac taagccacct 1313Ile Ala Asn Lys Arg Asp Arg Glu Ala Gly Asn Asn 390395400 tttcaagcat cca 1326<210>336<211>401<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>336Met Thr Asn Arg Ile Val Leu Ala Tyr Ser Gly Gly Leu Asp Thr Thr 151015 Val Ala Ile Pro Tyr Leu Lys Lys Met Ile Asp Gly Glu Val Ile Ala

20 25 30Val Ser Leu Asp Leu Gly Gln Gly Gly Glu Asn Met Asp Asn Val Arg

35 40 45Gln Arg Ala Leu Asp Ala Gly Ala Ala Glu Ser Ile Val Val Asp Ala

50 55 60Lys Asp Glu Phe Ala Glu Glu Tyr Cys Leu Pro Thr Ile Lys Ala Asn 65 70 75 80Gly Met Tyr Met Lys Gln Tyr Pro Leu Val Ser Ala Ile Ser Arg Pro

85 90 95Leu Ile Val Lys His Leu Val Glu Ala Gly Lys Gln Phe Asn Gly Thr

100 105 110His Val Ala His Gly Cys Thr Gly Lys Gly Asn Asp Gln Val Arg Phe

115 120 125Glu Val Gly Phe Met Asp Thr Asp Pro Asn Leu Glu Ile Ile Ala Pro

130 135 140Ala Arg Asp Phe Ala Trp Thr Arg Asp Lys Ala Ile Ala Phe Ala Glu145 150 155 160Glu Asn Asn Val Pro Ile Glu Gln Ser Val Lys Ser Pro Phe Ser Ile

165 170 175Asp Gln Asn Val Trp Gly Arg Ala Ile Glu Thr Gly Tyr Leu Glu Asp

180 185 190Leu Trp Asn Ala Pro Thr Lys Asp Ile Tyr Ala Tyr Thr Glu Asp Pro

195 200 205Ala Leu Gly Asn Ala Pro Asp Glu Val Ile Ile Ser Phe Glu Gly Gly

210 215 220Lys Pro Val Ser Ile Asp Gly Arg Pro Val Ser Val Leu Gln Ala Ile225 230 235 240Glu Glu Leu Asn Arg Arg Ala Gly Ala Gln Gly Val Gly Arg Leu Asp

245 250 255Met Val Glu Asp Arg Leu Val Gly Ile Lys Ser Arg Glu Ile Tyr Glu

260 265 270Ala Pro Gly Ala Ile Ala Leu Ile Lys Ala His Glu Ala Leu Glu Asp

275 280 285Val Thr Ile Glu Arg Glu Leu Ala Arg Tyr Lys Arg Gly Val Asp Ala

290 295 300Arg Trp Ala Glu Glu Val Tyr Asp Gly Leu Trp Phe Gly Pro Leu Lys305310 315 320Arg Ser Leu Asp Ala Phe Ile Asp Ser Thr Gln Glu His Val Thr Gly

325 330 335Asp Ile Arg Met Val Leu His Ala Gly Ser Ile Thr Ile Asn Gly Arg

340 345 350Arg Ser Ser His Ser Leu Tyr Asp Phe Asn Leu Ala Thr Tyr Asp Thr

355 360 365Gly Asp Thr Phe Asp Gln Thr Leu Ala Lys Gly Phe Val Gln Leu His

370375380 Gly Leu Ser Ser Lys Ile Ala Asn Lys Arg Asp Arg Glu Ala Gly Asn 385390395400 Asn<210>337<211>1554<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1531)<223>RXN02162<400>337gatcgctaac aagcgcgatc gcgaagctgg caacaactaa gccacctttt caagcatcca 60gactagaact tcaagtattt agaaagtaga agaacaccac atg gaa cag cac gga 115

Met Glu Gln His Gly

1 5acc aat gaa ggt gcg ctg tgg ggc ggc cgc ttc tcc ggt gga ccc tcc 163Thr Asn Glu Gly Ala Leu Trp Gly Gly Arg Phe Ser Gly Gly Pro Ser

10 15 20gag gcc atg ttc gcc ttg agt gtc tcc act cat ttc gac tgg gtt ttg 211Glu Ala Met Phe Ala Leu Ser Val Ser Thr His Phe Asp Trp Val Leu

25 30 35gcc cct tat gat gtg ttg gcc tcc aag gca cac gcc aag gtt ttg cac 259Ala Pro Tyr Asp Val Leu Ala Ser Lys Ala His Ala Lys Val Leu His

40 45 50caa gca gat cta ctt tct gat gaa gat cta gcc acc atg ctg gct ggg 307Gln Ala Asp Leu Leu Ser Asp Glu Asp Leu Ala Thr Met Leu Ala Gly

55 60 65ctt gat cag ctg ggc aag gat gtc gcc gac gga acc ttc ggt ccg ctg 355Leu Asp Gln Leu Gly Lys Asp Val Ala Asp Gly Thr Phe Gly Pro Leu 70 75 80 85cct tct gat gag gat gtg cac ggc gcg atg gaa cgc ggt gtg att gac 403Pro Ser Asp Glu Asp Val His Gly Ala Met Glu Arg Gly Val Ile Asp

90 95 100cgc gtt ggt cct gag gtg ggc ggc cgt ctg cgc gct ggt cgt tcc cgc 451Arg Val Gly Pro Glu Val Gly Gly Arg Leu Arg Ala Gly Arg Ser Arg

105 110 115aac gac cag gtg gca acc ctg ttc cgc atg tgg gtc cgc gac gca gtg 499Asn Asp Gln Val Ala Thr Leu Phe Arg Met Trp Val Arg Asp Ala Val

120 125 130cgc gac atc gcg ctg gga aca acc gag ctt gtc gac gcc ctc agc gcc 547Arg Asp Ile Ala Leu Gly Thr Thr Glu Leu Val Asp Ala Leu Ser Ala

135 140 145caa gct aag gca cat gca ggc gcg atc atg cca ggc aag acc cac ttc 595Gln Ala Lys Ala His Ala Gly Ala Ile Met Pro Gly Lys Thr His Phe150 155 160 165cag gca gct cag ccg gtc ctt ctg gca cac cag ctg ctg gca cac gca 643Gln Ala Ala Gln Pro Val Leu Leu Ala His Gln Leu Leu Ala His Ala

170 175 180cag cct ttg ctg cgc gat att gat cgt atc cgt gac ctg gac aag cgt 691Gln Pro Leu Leu Arg Asp Ile Asp Arg Ile Arg Asp Leu Asp Lys Arg

185 190 195ctt gcg gtg tct cct tac ggt tcc ggc gca ctt gct ggt tcc tct ttg 739Leu Ala Val Ser Pro Tyr Gly Ser Gly Ala Leu Ala Gly Ser Ser Leu

200 205 210aag ctc aac cct gaa gca atc gct gaa gaa ctc ggc ttt gat tcc gca 787Lys Leu Asn Pro Glu Ala Ile Ala Glu Glu Leu Gly Phe Asp Ser Ala

215 220 225gca gat aac tcc att gat gcc acc agc tcc cgc gat ttc gca tct gaa 835Ala Asp Asn Ser Ile Asp Ala Thr Ser Ser Arg Asp Phe Ala Ser Glu230 235 240 245acc gcc ttc gtg ctg gcg cag ctt gca gtg gat atg tcc cgc ttg gct 883Thr Ala Phe Val Leu Ala Gln Leu Ala Val Asp Met Ser Arg Leu Ala

250 255 260gaa gaa atc atc gca tgg tgc acc cca gaa ttt ggt tac atc acc ttg 931Glu Glu Ile Ile Ala Trp Cys Thr Pro Glu Phe Gly Tyr Ile Thr Leu

265 270 275tct gat tcc tgg tcc aca ggc agc tca atc atg ccg cag aag aag aac 979Ser Asp Ser Trp Ser Thr Gly Ser Ser Ile Met Pro Gln Lys Lys Asn

280 285 290cct gac gtg gca gag ctg acc cgt ggc aag tct ggt cgc ttg atc ggt 1027Pro Asp Val Ala Glu Leu Thr Arg Gly Lys Ser Gly Arg Leu Ile Gly

295 300 305aac ctc acc ggt ctg ctg gct acc ctg aag gca cag cct tta gcg tac 1075Asn Leu Thr Gly Leu Leu Ala Thr Leu Lys Ala Gln Pro Leu Ala Tyr310 315 320 325aac cgc gac ctg cag gaa gat aag gaa cca atc gta gat tcc gtg gcg 1123Asn Arg Asp Leu Gln Glu Asp Lys Glu Pro Ile Val Asp Ser Val Ala

330 335 340cag ctc aac ctg ctg ctc cct gca atg act ggt ttg gtt tcc acc ttg 1171Gln Leu Asn Leu Leu Leu Pro Ala Met Thr Gly Leu Val Ser Thr Leu

345 350 355acc ttc aac acc gag cgc atg cgt gaa ctt gca cca gca ggt ttc acc 1219Thr Phe Asn Thr Glu Arg Met Arg Glu Leu Ala Pro Ala Gly Phe Thr

360 365 370ctt gcc acc gac ttg gct gag tgg atg gtg cgc cag ggc gtt cca ttc 1267Leu Ala Thr Asp Leu Ala Glu Trp Met Val Arg Gln Gly Val Pro Phe

375 380 385cgt gag gca cac gaa gca tcc ggc gct tgc gtg cgg atc gcg gag tcc 1315Arg Glu Ala His Glu Ala Ser Gly Ala Cys Val Arg Ile Ala Glu Ser390 395 400 405agg gga gtg gac ctt atc gat ctc act gat gaa gaa ctc agt ggc gtt 1363Arg Gly Val Asp Leu Ile Asp Leu Thr Asp Glu Glu Leu Ser Gly Val

410 415 420gat gca cgt ctg acc cca gag gta cgg gaa gtg ctc acc att gat ggt 1411Asp Ala Arg Leu Thr Pro Glu Val Arg Glu Val Leu Thr Ile Asp Gly

425 430 435gca gtg gct tcc cgt gca acg cgc ggt gga acc gcg ggc gtg cgg gtt 1459Ala Val Ala Ser Arg Ala Thr Arg Gly Gly Thr Ala Gly Val Arg Val

440 445 450gcg gag caa cgc gca cgt gtc gat gcc gca agt acc gct cac gcg gag 1507Ala Glu Gln Arg Ala Arg Val Asp Ala Ala Ser Thr Ala His Ala Glu

455460465 tgg gca cgt gcg ggg gta cgt cga taagcattag tttatggcct gtg 1554Trp Ala Arg Ala Gly Val Arg Arg 470475<210>338<211>477<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>338Met Glu Gln His Gly Thr Asn Glu Gly Ala Leu Trp Gly Gly Arg Phe 151015 Ser Gly Gly Pro Ser Glu Ala Met Phe Ala Leu Ser Val Ser Thr His

20 25 30Phe Asp Trp Val Leu Ala Pro Tyr Asp Val Leu Ala Ser Lys Ala His

35 40 45Ala Lys Val Leu His Gln Ala Asp Leu Leu Ser Asp Glu Asp Leu Ala

5055 60Thr Met Leu Ala Gly Leu Asp Gln Leu Gly Lys Asp Val Ala Asp Gly 65 70 75 80Thr Phe Gly Pro Leu Pro Ser Asp Glu Asp Val His Gly Ala Met Glu

85 90 95Arg Gly Val Ile Asp Arg Val Gly Pro Glu Val Gly Gly Arg Leu Arg

100 105 110Ala Gly Arg Ser Arg Asn Asp Gln Val Ala Thr Leu Phe Arg Met Trp

115 120 125Val Arg Asp Ala Val Arg Asp Ile Ala Leu Gly Thr Thr Glu Leu Val

130 135 140Asp Ala Leu Ser Ala Gln Ala Lys Ala His Ala Gly Ala Ile Met Pro145 150 155 160Gly Lys Thr His Phe Gln Ala Ala Gln Pro Val Leu Leu Ala His Gln

165 170 175Leu Leu Ala His Ala Gln Pro Leu Leu Arg Asp Ile Asp Arg Ile Arg

180 185 190Asp Leu Asp Lys Arg Leu Ala Val Ser Pro Tyr Gly Ser Gly Ala Leu

195 200 205Ala Gly Ser Ser Leu Lys Leu Asn Pro Glu Ala Ile Ala Glu Glu Leu

210 215 220Gly Phe Asp Ser Ala Ala Asp Asn Ser Ile Asp Ala Thr Ser Ser Arg225 230 235 240Asp Phe Ala Ser Glu Thr Ala Phe Val Leu Ala Gln Leu Ala Val Asp

245 250 255Met Ser Arg Leu Ala Glu Glu Ile Ile Ala Trp Cys Thr Pro Glu Phe

260 265 270Gly Tyr Ile Thr Leu Ser Asp Ser Trp Ser Thr Gly Ser Ser Ile Met

275 280285Pro Gln Lys Lys Asn Pro Asp Val Ala Glu Leu Thr Arg Gly Lys Ser

290 295 300Gly Arg Leu Ile Gly Asn Leu Thr Gly Leu Leu Ala Thr Leu Lys Ala305 310 315 320Gln Pro Leu Ala Tyr Asn Arg Asp Leu Gln Glu Asp Lys Glu Pro Ile

325 330 335Val Asp Ser Val Ala Gln Leu Asn Leu Leu Leu Pro Ala Met Thr Gly

340 345 350Leu Val Ser Thr Leu Thr Phe Asn Thr Glu Arg Met Arg Glu Leu Ala

355 360 365Pro Ala Gly Phe Thr Leu Ala Thr Asp Leu Ala Glu Trp Met Val Arg

370 375 380Gln Gly Val Pro Phe Arg Glu Ala His Glu Ala Ser Gly Ala Cys Val385 390 395 400Arg Ile Ala Glu Ser Arg Gly Val Asp Leu Ile Asp Leu Thr Asp Glu

405 410 415Glu Leu Ser Gly Val Asp Ala Arg Leu Thr Pro Glu Val Arg Glu Val

420 425 430Leu Thr Ile Asp Gly Ala Val Ala Ser Arg Ala Thr Arg Gly Gly Thr

435 440 445Ala Gly Val Arg Val Ala Glu Gln Arg Ala Arg Val Asp Ala Ala Ser

450455460 Thr Ala His Ala Glu Trp Ala Arg Ala Gly Val Arg Arg 465470475<210>339<211>906<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (883)<223>FRXA02161<220><221><misc _ feature<222>863<223>n ═ a, c, g, or t<220><221>VARIANT<222>255<223>Xaa ═ Cys, Arg, Ser, or Gly<400>339gatcgctaac aagcgcgatc gcgaagctgg caacaactaa gccacctttt caagcatcca 60gactagaact tcaagtattt agaaagtaga agaacaccac atg gaa cag cac gga 115

Met Glu Gln His Gly

1 5acc aat gaa ggt gcg ctg tgg ggc ggc cgc ttc tcc ggt gga ccc tcc 163Thr Asn Glu Gly Ala Leu Trp Gly Gly Arg Phe Ser Gly Gly Pro Ser

10 15 20gag gcc atg ttc gcc ttg agt gtc tcc act cat ttc gac tgg gtt ttg 211Glu Ala Met Phe Ala Leu Ser Val Ser Thr His Phe Asp Trp Val Leu

25 30 35gcc cct tat gat gtg ttg gcc tcc aag gca cac gcc aag gtt ttg cac 259Ala Pro Tyr Asp Val Leu Ala Ser Lys Ala His Ala Lys Val Leu His

40 45 50caa gca gat cta ctt tct gat gaa gat cta gcc acc atg ctg gct ggg 307Gln Ala Asp Leu Leu Ser Asp Glu Asp Leu Ala Thr Met Leu Ala Gly

55 60 65ctt gat cag ctg ggc aag gat gtc gcc gac gga acc ttc ggt ccg ctg 355Leu Asp Gln Leu Gly Lys Asp Val Ala Asp Gly Thr Phe Gly Pro Leu 70 75 80 85cct tct gat gag gat gtg cac ggc gcg atg gaa cgc ggt gtg att gac 403Pro Ser Asp Glu Asp Val His Gly Ala Met Glu Arg Gly Val Ile Asp

90 95 100cgc gtt ggt cct gag gtg ggc ggc cgt ctg cgc gct ggt cgt tcc cgc 451Arg Val Gly Pro Glu Val Gly Gly Arg Leu Arg Ala Gly Arg Ser Arg

105 110 115aac gac cag gtg gca acc ctg ttc cgc atg tgg gtc cgc gac gca gtg 499Asn Asp Gln Val Ala Thr Leu Phe Arg Met Trp Val Arg Asp Ala Val

120 125130cgc gac atc gcg ctg gga aca acc gag ctt gtc gac gcc ctc agc gcc 547Arg Asp Ile Ala Leu Gly Thr Thr Glu Leu Val Asp Ala Leu Ser Ala

135 140 145caa gct aag gca cat gca ggc gcg atc atg cca ggc aag acc cac ttc 595Gln Ala Lys Ala His Ala Gly Ala Ile Met Pro Gly Lys Thr His Phe150 155 160 165cag gca gct cag ccg gtc ctt ctg gca cac cag ctg ctg gca cac gca 643Gln Ala Ala Gln Pro Val Leu Leu Ala His Gln Leu Leu Ala His Ala

170 175 180cag cct ttg ctg cgc gat att gat cgt atc cgt gac ctg gac aag cgt 691Gln Pro Leu Leu Arg Asp Ile Asp Arg Ile Arg Asp Leu Asp Lys Arg

185 190 195ctt gcg gtg tct cct tac ggt tcc ggc gca ctt gct ggt tcc tct ttg 739Leu Ala Val Ser Pro Tyr Gly Ser Gly Ala Leu Ala Gly Ser Ser Leu

200 205 210aag ctc aac cct gaa gca atc gct gaa gaa ctc ggc ttt gat tcc gca 787Lys Leu Asn Pro Glu Ala Ile Ala Glu Glu Leu Gly Phe Asp Ser Ala

215 220 225gca gat aac tcc att gat gcc acc agc tcc cgc gat ttc gca tct gaa 835Ala Asp Asn Ser Ile Asp Ala Thr Ser Ser Arg Asp Phe Ala Ser Glu230 235 240 245acc gcc ttc gtg ctg gcg cag ctt gca ngt gga tat gtc ccg ctt ggc 883Thr Ala Phe Val Leu Ala Gln Leu Ala Xaa Gly Tyr Val Pro Leu Gly

250255260 tgaagaaatc atcgcatggt gca 906<210>340<211>261<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>VARIANT<222>255<223>Xaa ═ Cys, Arg, Ser, or Gly<400>340Met Glu Gln His Gly Thr Asn Glu Gly Ala Leu Trp Gly Gly Arg Phe 151015 Ser Gly Gly Pro Ser Glu Ala Met Phe Ala Leu Ser Val Ser Thr His

20 25 30Phe Asp Trp Val Leu Ala Pro Tyr Asp Val Leu Ala Ser Lys Ala His

35 40 45Ala Lys Val Leu His Gln Ala Asp Leu Leu Ser Asp Glu Asp Leu Ala

50 55 60Thr Met Leu Ala Gly Leu Asp Gln Leu Gly Lys Asp Val Ala Asp Gly 65 70 75 80Thr Phe Gly Pro Leu Pro Ser Asp Glu Asp Val His Gly Ala Met Glu

85 90 95Arg Gly Val Ile Asp Arg Val Gly Pro Glu Val Gly Gly Arg Leu Arg

100 105 110Ala Gly Arg Ser Arg Asn Asp Gln Val Ala Thr Leu Phe Arg Met Trp

115 120 125Val Arg Asp Ala Val Arg Asp Ile Ala Leu Gly Thr Thr Glu Leu Val

130 135 140Asp Ala Leu Ser Ala Gln Ala Lys Ala His Ala Gly Ala Ile Met Pro145 150 155 160Gly Lys Thr His Phe Gln Ala Ala Gln Pro Val Leu Leu Ala His Gln

165 170 175Leu Leu Ala His Ala Gln Pro Leu Leu Arg Asp Ile Asp Arg Ile Arg

180 185 190Asp Leu Asp Lys Arg Leu Ala Val Ser Pro Tyr Gly Ser Gly Ala Leu

195 200 205Ala Gly Ser Ser Leu Lys Leu Asn Pro Glu Ala Ile Ala Glu Glu Leu

210 215 220Gly Phe Asp Ser Ala Ala Asp Asn Ser Ile Asp Ala Thr Ser Ser Arg225 230 235 240Asp Phe Ala Ser Glu Thr Ala Phe Val Leu Ala Gln Leu Ala Xaa Gly

245 250 255Tyr Val Pro Leu Gly

260<210>341<211>786<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (763)<223>FRXA02162<220><221>misc _ failure<222>94<223>n ═ a, c, g, or t<400>341ctcggctttg attccgcagc agataactcc attgatgcca ccagctcccg cgatttcgca 60 3860 60tctgaaaccg ccttcgtgct ggcgcagctt gcancgtggat atg tcc cgc ttg gct 115

Met Ser Arg Leu Ala

1 5gaa gaa atc atc gca tgg tgc acc cca gaa ttt ggt tac atc acc ttg 163Glu Glu Ile Ile Ala Trp Cys Thr Pro Glu Phe Gly Tyr Ile Thr Leu

10 15 20tct gat tcc tgg tcc aca ggc agc tca atc atg ccg cag aag aag aac 211Ser Asp Ser Trp Ser Thr Gly Ser Ser Ile Met Pro Gln Lys Lys Asn

25 30 35cct gac gtg gca gag ctg acc cgt ggc aag tct ggt cgc ttg atc ggt 259Pro Asp Val Ala Glu Leu Thr Arg Gly Lys Ser Gly Arg Leu Ile Gly

40 45 50aac ctc acc ggt ctg ctg gct acc ctg aag gca cag cct tta gcg tac 307Asn Leu Thr Gly Leu Leu Ala Thr Leu Lys Ala Gln Pro Leu Ala Tyr

55 60 65aac cgc gac ctg cag gaa gat aag gaa cca atc gta gat tcc gtg gcg 355Asn Arg Asp Leu Gln Glu Asp Lys Glu Pro Ile Val Asp Ser Val Ala 70 75 80 85cag ctc aac ctg ctg ctc cct gca atg act ggt ttg gtt tcc acc ttg 403Gln Leu Asn Leu Leu Leu Pro Ala Met Thr Gly Leu Val Ser Thr Leu

90 95100acc ttc aac acc gag cgc atg cgt gaa ctt gca cca gca ggt ttc acc 451Thr Phe Asn Thr Glu Arg Met Arg Glu Leu Ala Pro Ala Gly Phe Thr

105 110 115ctt gcc acc gac ttg gct gag tgg atg gtg cgc cag ggc gtt cca ttc 499Leu Ala Thr Asp Leu Ala Glu Trp Met Val Arg Gln Gly Val Pro Phe

120 125 130cgt gag gca cac gaa gca tcc ggc gct tgc gtg cgg atc gcg gag tcc 547Arg Glu Ala His Glu Ala Ser Gly Ala Cys Val Arg Ile Ala Glu Ser

135 140 145agg gga gtg gac ctt atc gat ctc act gat gaa gaa ctc agt ggc gtt 595Arg Gly Val Asp Leu Ile Asp Leu Thr Asp Glu Glu Leu Ser Gly Val150 155 160 165gat gca cgt ctg acc cca gag gta cgg gaa gtg ctc acc att gat ggt 643Asp Ala Arg Leu Thr Pro Glu Val Arg Glu Val Leu Thr Ile Asp Gly

170 175 180gca gtg gct tcc cgt gca acg cgc ggt gga acc gcg ggc gtg cgg gtt 691Ala Val Ala Ser Arg Ala Thr Arg Gly Gly Thr Ala Gly Val Arg Val

185 190 195gcg gag caa cgc gca cgt gtc gat gcc gca agt acc gct cac gcg gag 739Ala Glu Gln Arg Ala Arg Val Asp Ala Ala Ser Thr Ala His Ala Glu

200 205 210tgg gca cgt gcg ggg gta cgt cga taagcattag tttatggcct gtg 786Trp Ala Arg Ala Gly Val Arg Arg

215220<210>342<211>221<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>342Met Ser Arg Leu Ala Glu Glu Ile Ile Ala Trp Cys Thr Pro Glu Phe 151015 Gly Tyr Ile Thr Leu Ser Asp Ser Trp Ser Thr Gly Ser Ser Ile Met

20 25 30Pro Gln Lys Lys AsnPro Asp Val Ala Glu Leu Thr Arg Gly Lys Ser

35 40 45Gly Arg Leu Ile Gly Asn Leu Thr Gly Leu Leu Ala Thr Leu Lys Ala

50 55 60Gln Pro Leu Ala Tyr Asn Arg Asp Leu Gln Glu Asp Lys Glu Pro Ile 65 70 75 80Val Asp Ser Val Ala Gln Leu Asn Leu Leu Leu Pro Ala Met Thr Gly

85 90 95Leu Val Ser Thr Leu Thr Phe Asn Thr Glu Arg Met Arg Glu Leu Ala

100 105 110Pro Ala Gly Phe Thr Leu Ala Thr Asp Leu Ala Glu Trp Met Val Arg

115 120 125Gln Gly Val Pro Phe Arg Glu Ala His Glu Ala Ser Gly Ala Cys Val

130 135 140Arg Ile Ala Glu Ser Arg Gly Val Asp Leu Ile Asp Leu Thr Asp Glu145 150 155 160Glu Leu Ser Gly Val Asp Ala Arg Leu Thr Pro Glu Val Arg Glu Val

165 170 175Leu Thr Ile Asp Gly Ala Val Ala Ser Arg Ala Thr Arg Gly Gly Thr

180 185 190Ala Gly Val Arg Val Ala Glu Gln Arg Ala Arg Val Asp Ala Ala Ser

195 200 205Thr Ala His Ala Glu Trp Ala Arg Ala Gly Val Arg Arg

210215220<210>343<211>1269<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1246)<223>RXA02262<400>343gcaccaattt cggacctgaa atccccgagg aaaccgtgcc cgacgccgtg caggtgggcg 60tcgataagca aaaaatcgct gatactcgaa aggcctcaaa atg acc gca acc tac 115

Met Thr Ala Thr Tyr

1 5acc act gaa acc gcc atc aat ttc ttg ttc ttg agc gaa ccg gac atg 163Thr Thr Glu Thr Ala Ile Asn Phe Leu Phe Leu Ser Glu Pro Asp Met

10 15 20atc gcg gcc gga gtc aaa gac gtc gcg caa tgc gtc gat gtc atg gag 211Ile Ala Ala Gly Val Lys Asp Val Ala Gln Cys Val Asp Val Met Glu

25 30 35gaa acg ctc gtg ctc ttg gcg cag ggc gac tac aaa atg gcc ggt ttg 259Glu Thr Leu Val Leu Leu Ala Gln Gly Asp Tyr Lys Met Ala Gly Leu

40 45 50aac tcc aac tcg cat ggc gcg atg atc acc ttc ccg gaa aac cca gaa 307Asn Ser Asn Ser His Gly Ala Met Ile Thr Phe Pro Glu Asn Pro Glu

55 60 65ttt gaa ggc atg ccc aag gac ggc ccc gac cgc cga ttc atg gcg atg 355Phe Glu Gly Met Pro Lys Asp Gly Pro Asp Arg Arg Phe Met Ala Met 70 75 80 85ccc gca tac ctc ggc ggg cga ttc aaa aac acc ggc gtg aag tgg tac 403Pro Ala Tyr Leu Gly Gly Arg Phe Lys Asn Thr Gly Val Lys Trp Tyr

90 95 100gga tcc aac gcg gaa aac aag gcc tca ggc ttg cct cgc tcg atc cac 451Gly Ser Asn Ala Glu Asn Lys Ala Ser Gly Leu Pro Arg Ser Ile His

105 110 115acc ttc gtc ctc aac gac acg gtc acc ggt gca ccg aag gcc atc atg 499Thr Phe Val Leu Asn Asp Thr Val Thr Gly Ala Pro Lys Ala Ile Met

120 125 130tcc gcg aac ctg ctg tcc gcc tac cgc acc ggc gcg gtt ccc ggc gtg 547Ser Ala Asn Leu Leu Ser Ala Tyr Arg Thr Gly Ala Val Pro Gly Val

135 140 145ggc gtg aag cac tta gcg gtc gcc gac gcg aca acc ttg gct gtc gtc 595Gly Val Lys His Leu Ala Val Ala Asp Ala Thr Thr Leu Ala Val Val150 155 160 165gga cct ggt gtc atg gcg aaa acc atc acc gaa gcg tgc atc gca gag 643Gly Pro Gly Val Met Ala Lys Thr Ile Thr Glu Ala Cys Ile Ala Glu

170 175 180cgc cca gga atc acc acc atc aag atc aag gga cgc agc gaa cgc ggc 691Arg Pro Gly Ile Thr Thr Ile Lys Ile Lys Gly Arg Ser Glu Arg Gly

185 190 195atc aac gcc ttt gca aca tgg gcg ttg gaa aaa ttc ccc gag atc gaa 739Ile Asn Ala Phe Ala Thr Trp Ala Leu Glu Lys Phe Pro Glu Ile Glu

200 205 210gtg gtc gcc gtc gga tct gaa gaa gac gtg gtc aaa gac gcc gac atc 787Val Val Ala Val Gly Ser Glu Glu Asp Val Val Lys Asp Ala Asp Ile

215 220 225gtc atc gcc gcc acc acc acg gac gcc gcc ggc tcc tcc gcc ttc cca 835Val Ile Ala Ala Thr Thr Thr Asp Ala Ala Gly Ser Ser Ala Phe Pro230 235 240 245tac ttc aaa aaa gaa tgg ctc aag ccg ggc gca ttg ctg ctg ctt cca 883Tyr Phe Lys Lys Glu Trp Leu Lys Pro Gly Ala Leu Leu Leu Leu Pro

250 255 260gcc gcc ggt cgc ttc gac gac gct tat ttg ctt gac gac gcc cgc ctc 931Ala Ala Gly Arg Phe Asp Asp Ala Tyr Leu Leu Asp Asp Ala Arg Leu

265 270 275gtt gtt gac tac atg ggg ctc tac gaa gcc tgg gca gaa gaa tac ggc 979Val Val Asp Tyr Met Gly Leu Tyr Glu Ala Trp Ala Glu Glu Tyr Gly

280 285 290cca cag gcc tac caa cta ctcggc att cca gga acc cac tgg tac gac 1027Pro Gln Ala Tyr Gln Leu Leu Gly Ile Pro Gly Thr His Trp Tyr Asp

295 300 305ctg gcg ctg caa gga aaa ctc gac ctt gca aag att tcc cag att ggc 1075Leu Ala Leu Gln Gly Lys Leu Asp Leu Ala Lys Ile Ser Gln Ile Gly310 315 320 325gat atc tgc tcc ggc aag cta ccc gga cgc acc aac gat gag gaa atc 1123Asp Ile Cys Ser Gly Lys Leu Pro Gly Arg Thr Asn Asp Glu Glu Ile

330 335 340atc ctc tat tcc gtc ggc ggc atg cca gta gaa gac gtc gcc tgg gca 1171Ile Leu Tyr Ser Val Gly Gly Met Pro Val Glu Asp Val Ala Trp Ala

345 350 355acc caa gtg tat gaa aac gcc ctg gaa aaa ggc gtc ggc acc aca ttg 1219Thr Gln Val Tyr Glu Asn Ala Leu Glu Lys Gly Val Gly Thr Thr Leu

360 365 370aac ctg tgg gaa tca ccc gca ctg gct tgagagaaga aacaacaatg 1266Asn Leu Trp Glu Ser Pro Ala Leu Ala

375380 aaa 1269<210>344<211>382<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>344Met Thr Ala Thr Tyr Thr Thr Glu Thr Ala Ile Asn Phe Leu Phe Leu 151015 Ser Glu Pro Asp Met Ile Ala Ala Gly Val Lys Asp Val Ala Gln Cys

20 25 30Val Asp Val Met Glu Glu Thr Leu Val Leu Leu Ala Gln Gly Asp Tyr

35 40 45Lys Met Ala Gly Leu Asn Ser Asn Ser His Gly Ala Met Ile Thr Phe

50 55 60Pro Glu Asn Pro Glu Phe Glu Gly Met Pro Lys Asp Gly Pro Asp Arg 65 70 75 80Arg Phe Met Ala Met Pro Ala Tyr Leu Gly Gly Arg Phe Lys Asn Thr

85 90 95Gly Val Lys Trp Tyr Gly Ser Asn Ala Glu Asn Lys Ala Ser Gly Leu

100 105 110Pro Arg Ser Ile His Thr Phe Val Leu Asn Asp Thr Val Thr Gly Ala

115 120 125Pro Lys Ala Ile Met Ser Ala Asn Leu Leu Ser Ala Tyr Arg Thr Gly

130 135 140Ala Val Pro Gly Val Gly Val Lys His Leu Ala Val Ala Asp Ala Thr145 150 155 160Thr Leu Ala Val Val Gly Pro Gly Val Met Ala Lys Thr Ile Thr Glu

165 170 175Ala Cys Ile Ala Glu Arg Pro Gly Ile Thr Thr Ile Lys Ile Lys Gly

180 185 190Arg Ser Glu Arg Gly Ile Asn Ala Phe Ala Thr Trp Ala Leu Glu Lys

195 200 205Phe Pro Glu Ile Glu Val Val Ala Val Gly Ser Glu Glu Asp Val Val

210 215 220Lys Asp Ala Asp Ile Val Ile Ala Ala Thr Thr Thr Asp Ala Ala Gly225 230 235 240Ser Ser Ala Phe Pro Tyr Phe Lys Lys Glu Trp Leu Lys Pro Gly Ala

245 250 255Leu Leu Leu Leu Pro Ala Ala Gly Arg Phe Asp Asp Ala Tyr Leu Leu

260 265 270Asp Asp Ala Arg Leu Val Val Asp Tyr Met Gly Leu Tyr Glu Ala Trp

275 280 285Ala Glu Glu Tyr Gly Pro Gln Ala Tyr Gln Leu Leu Gly Ile Pro Gly

290 295 300Thr His Trp Tyr Asp Leu Ala Leu Gln Gly Lys Leu Asp Leu Ala Lys305 310 315 320Ile Ser Gln Ile Gly Asp Ile Cys Ser Gly Lys Leu Pro Gly Arg Thr

325 330 335Asn Asp Glu Glu Ile Ile Leu Tyr Ser Val Gly Gly Met Pro Val Glu

340 345 350Asp Val Ala Trp Ala Thr Gln Val Tyr Glu Asn Ala Leu Glu Lys Gly

355 360 365Val Gly Thr Thr Leu Asn Leu Trp Glu Ser Pro Ala Leu Ala

370375380<210>345<211>1065<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1042)<223>RXA00219<400>345tttgccgtac atgcgcgagc acctcctcaa cagcccgcac caccgaccaa tcacataaga 60cacaagcact aaaacagcat taaagaaaga aagctttttc gtg gcc cgt aag aaa 115

Val Ala Arg Lys Lys

1 5aac acg tcc gat caa tcc cgc tcc caa gct gcc aac acg ccc att gct 163Asn Thr Ser Asp Gln Ser Arg Ser Gln Ala Ala Asn Thr Pro Ile Ala

10 15 20ggc acc tat gag ggt gaa tat tcc gtc atc gag ttg gag gcc gat tcc 211Gly Thr Tyr Glu Gly Glu Tyr Ser Val Ile Glu Leu Glu Ala Asp Ser

25 30 35tac acc acc gat ggc tgg ttg atc agc att aat ggc gtg ccc agc tct 259Tyr Thr Thr Asp Gly Trp Leu Ile Ser Ile Asn Gly Val Pro Ser Ser

40 45 50cat att gtc ctg ggg caa ccg cag gca ctg gaa ttt gag tac atg cgg 307His Ile Val Leu Gly Gln Pro Gln Ala Leu Glu Phe Glu Tyr Met Arg

55 60 65tgg atc gct acc ggc gct cgg gcg ttc atc gat gcg cat cag gat gca 355Trp Ile Ala Thr Gly Ala Arg Ala Phe Ile Asp Ala His Gln Asp Ala 70 75 80 85tcc aag ctg cgg att act cac ctc ggc ggc ggt gcg tgc acg atg gcc 403Ser Lys Leu Arg Ile Thr His Leu Gly Gly Gly Ala Cys Thr Met Ala

90 95 100agg tat ttc gcg gat gtt tac ccg cag tca cgc aac act gtc gtg gaa 451Arg Tyr Phe Ala Asp Val Tyr Pro Gln Ser Arg Asn Thr Val Val Glu

105 110 115ttg gat gca gag ctt gcc cgc ctg tcg cgt gaa tgg ttc gac att ccg 499Leu Asp Ala Glu Leu Ala Arg Leu Ser Arg Glu Trp Phe Asp Ile Pro

120 125 130cgc gcg cca cgg gta aag att cgt gtg gat gat gcc cga atg gtg gca 547Arg Ala Pro Arg Val Lys Ile Arg Val Asp Asp Ala Arg Met Val Ala

135 140 145gaa tct ttc act ccc gca agc cgc gat gtg atc atc cgt gac gtt ttt 595Glu Ser Phe Thr Pro Ala Ser Arg Asp Val Ile Ile Arg Asp Val Phe150 155 160 165gcc gga gct atc acg ccg cag aac ttc acc acc gtg gag ttc ttt gag 643Ala Gly Ala Ile Thr Pro Gln Asn Phe Thr Thr Val Glu Phe Phe Glu

170 175 180cac tgt cac cgt ggc ctt gct ccc ggc gga ttg tac gtt gcc aac tgt 691His Cys His Arg Gly Leu Ala Pro Gly Gly Leu Tyr Val Ala Asn Cys

185 190 195ggc gat cat tcg gat ctg cgc gga gct aaa tct gag ctc gcg gga atg 739Gly Asp His Ser Asp Leu Arg Gly Ala Lys Ser Glu Leu Ala Gly Met

200 205 210atg gag gtg ttc gag cac gtc gcg gtc atc gcc gat ccc ccg atg ctt 787Met Glu Val Phe Glu His Val Ala Val Ile Ala Asp ProPro Met Leu

215 220 225aaa ggg cgc cgt tac ggc aac atc att ttg atg ggt tca gac acc gag 835Lys Gly Arg Arg Tyr Gly Asn Ile Ile Leu Met Gly Ser Asp Thr Glu230 235 240 245ttc ttt agc tcc aac agc acg gaa gcg tcc gcg att acc cgt gag ctt 883Phe Phe Ser Ser Asn Ser Thr Glu Ala Ser Ala Ile Thr Arg Glu Leu

250 255 260ctt ggc ggc ggc gtt cca gcg cag tac aag gat gaa tcc tgg gtg cgg 931Leu Gly Gly Gly Val Pro Ala Gln Tyr Lys Asp Glu Ser Trp Val Arg

265 270 275aaa ttc gcc tcg gga gcc cag gcc cgc cac gat ggg gtc tct acc ctc 979Lys Phe Ala Ser Gly Ala Gln Ala Arg His Asp Gly Val Ser Thr Leu

280 285 290caa atg ccg agt gat act cca caa cac cct gcg gaa acg ccg gag cat 1027Gln Met Pro Ser Asp Thr Pro Gln His Pro Ala Glu Thr Pro Glu His

295300305 tca aac aca cag cca taaaaaattc cgctggcgcg tcc 1065Ser Asn Thr Gln Pro310<210>346<211>314<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>346Val Ala Arg Lys Lys Asn Thr Ser Asp Gln Ser Arg Ser Gln Ala Ala 151015 Asn Thr Pro Ile Ala Gly Thr Tyr Glu Gly Glu Tyr Ser Val Ile Glu

20 25 30Leu Glu Ala Asp Ser Tyr Thr Thr Asp Gly Trp Leu Ile Ser Ile Asn

35 40 45Gly Val Pro Ser Ser His Ile Val Leu Gly Gln Pro Gln Ala Leu Glu

50 55 60Phe Glu Tyr Met Arg Trp Ile Ala Thr Gly Ala Arg Ala Phe Ile Asp 65 70 75 80Ala His Gln Asp Ala Ser Lys Leu Arg Ile Thr His Leu Gly Gly Gly

85 90 95Ala Cys Thr Met Ala Arg Tyr Phe Ala Asp Val Tyr Pro Gln Ser Arg

100 105 110Asn Thr Val Val Glu Leu Asp Ala Glu Leu Ala Arg Leu Ser Arg Glu

115 120 125Trp Phe Asp Ile Pro Arg Ala Pro Arg Val Lys Ile Arg Val Asp Asp

130 135 140Ala Arg Met Val Ala Glu Ser Phe Thr Pro Ala Ser Arg Asp Val Ile145 150 155 160Ile Arg Asp Val Phe Ala Gly Ala Ile Thr Pro Gln Asn Phe Thr Thr

165 170 175Val Glu Phe Phe Glu His Cys His Arg Gly Leu Ala Pro Gly Gly Leu

180 185 190Tyr Val Ala Asn Cys Gly Asp His Ser Asp Leu Arg Gly Ala Lys Ser

195 200 205Glu Leu Ala Gly Met Met Glu Val Phe Glu His Val Ala Val Ile Ala

210 215 220Asp Pro Pro Met Leu Lys Gly Arg Arg Tyr Gly Asn Ile Ile Leu Met225 230 235 240Gly Ser Asp Thr Glu Phe Phe Ser Ser Asn Ser Thr Glu Ala Ser Ala

245 250 255Ile Thr Arg Glu Leu Leu Gly Gly Gly Val Pro Ala Gln Tyr Lys Asp

260 265 270Glu Ser Trp Val Arg Lys Phe Ala Ser Gly Ala Gln Ala Arg His Asp

275 280 285Gly Val Ser Thr Leu Gln Met Pro Ser Asp Thr Pro Gln His Pro Ala

290295300 Glu Thr Pro Glu His Ser Asn Thr Gln Pro 305310<210>347<211>1662<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1639)<223>RXA01508<400>347ttccgggacg tttccgtgat ctcgtggaag atcccaaact ccgttccggt gccgtcgtgg 60ccgccgtcat cttgatcgtg gtgggaaccg taaacgctgc atg tct gat tta gga 115

Met Ser Asp Leu Gly

1 5ccc atc tgg cgc tgg ctg tta tta gtt tcc gtc tcc att tgt gcg gca 163Pro Ile Trp Arg Trp Leu Leu Leu Val Ser Val Ser Ile Cys Ala Ala

10 15 20tcg ggg ctg gtc tat gag cta gcc ctg gta tcg ctt tcc acc agc ttg 211Ser Gly Leu Val Tyr Glu Leu Ala Leu Val Ser Leu Ser Thr Ser Leu

25 30 35aac ggt ggc gga att gta gaa acc tcc ctc atc gtc gca ggt tat gta 259Asn Gly Gly Gly Ile Val Glu Thr Ser Leu Ile Val Ala Gly Tyr Val

40 45 50gct gcc ctt gga ctt ggt gca ctg ctg gtc aag ccg ttt ctc aac tgg 307Ala Ala Leu Gly Leu Gly Ala Leu Leu Val Lys Pro Phe Leu Asn Trp

55 60 65cct gcg caa acc ttc ctc ggt gtg gaa acc ctc ctt gga ctt att ggt 355Pro Ala Gln Thr Phe Leu Gly Val Glu Thr Leu Leu Gly Leu Ile Gly 70 75 80 85ggt tgt tcc gcg ctg gtg ctg tat ttc acc ttc gcg acc atc ggc caa 403Gly Cys Ser Ala Leu Val Leu Tyr Phe Thr Phe Ala Thr Ile Gly Gln

90 95 100tcc ctg tgg att ctg gtg att gcc acc gct gca att ggc atc ctg gtc 451Ser Leu Trp Ile Leu Val Ile Ala Thr Ala Ala Ile Gly Ile Leu Val

105 110 115ggc gct gaa ctt cca ctg ctg atg acc atg atc cag caa ggc cgc ctc 499Gly Ala Glu Leu Pro Leu Leu Met Thr Met Ile Gln Gln Gly Arg Leu

120 125 130gcc gac gcc aaa acc aca gga tct ctg gtt gcc acc ttg aat gct gct 547Ala Asp Ala Lys Thr Thr Gly Ser Leu Val Ala Thr Leu Asn Ala Ala

135 140 145gat tac ctt ggc gca ctt tta ggt ggc ctg gcc tgg cct ttt gtg ttg 595Asp Tyr Leu Gly Ala Leu Leu Gly Gly Leu Ala Trp Pro Phe Val Leu150 155 160 165ctg ccg tgg ctt ggc atg atg cgc ggt gcc gca gca gcc gga atg atc 643Leu Pro Trp Leu Gly Met Met Arg Gly Ala Ala Ala Ala Gly Met Ile

170 175 180aac ctc gtt gca gca cta ttc gtg ggc tgt gtg ctg ctg cga cat ttg 691Asn Leu Val Ala Ala Leu Phe Val Gly Cys Val Leu Leu Arg His Leu

185 190 195ctt ccg cgc acc cac ttc ttc gta tcc gtg gtg gcg ctt ctt ctc gcg 739Leu Pro Arg Thr His Phe Phe Val Ser Val Val Ala Leu Leu Leu Ala

200 205 210atc gca gcg cta gcc acc gtg ttg gtg aaa tcc gac ggg atc gtt gcc 787Ile Ala Ala Leu Ala Thr Val Leu Val Lys Ser Asp Gly Ile Val Ala

215 220 225acc gcc cgc gca cag ctc tac cgc gac ccc gtg atc tat tca cac caa 835Thr Ala Arg Ala Gln Leu Tyr Arg Asp Pro Val Ile Tyr Ser His Gln230 235 240 245tct gac tac caa gac atc gta gtg aca gaa cga ggc aaa gac cga cgc 883Ser Asp Tyr Gln Asp Ile Val Val Thr Glu Arg Gly Lys Asp Arg Arg

250 255 260ctc tac ctc aat ggc ggt ttg cag tat tcc act cgt gac cag cat aga 931Leu Tyr Leu Asn Gly Gly Leu Gln Tyr Ser Thr Arg Asp Gln His Arg

265 270 275tat aca gaa tca ctg gtg tat cca agc ctt aat cca gag gca gaa tcg 979Tyr Thr Glu Ser Leu Val Tyr Pro Ser Leu Asn Pro Glu Ala Glu Ser

280 285 290gtg tta atc atc ggc ggt ggc gat ggc ctc gca gca cgg gaa ctc ctc 1027Val Leu Ile Ile Gly Gly Gly Asp Gly Leu Ala Ala Arg Glu Leu Leu

295 300 305cga ttc cca tca atg cag atc acc caa gtt gaa tta gac cca gaa gtc 1075Arg Phe Pro Ser Met Gln Ile Thr Gln Val Glu Leu Asp Pro Glu Val310 315 320 325atc gaa gta gcc aac aca gtg ctg cgc tct gac aat ggg gga gcg atg 1123Ile Glu Val Ala Asn Thr Val Leu Arg Ser Asp Asn Gly Gly Ala Met

330 335 340gaa gat ccc cgc gtc tcc atc atc gtt gac gac gct ttc acc tgg ctg 1171Glu Asp Pro Arg Val Ser Ile Ile Val Asp Asp Ala Phe Thr Trp Leu

345 350 355cgc tcc ggc gga aat aat ggc gaa act tac gat tcc atc atc atc gat 1219Arg Ser Gly Gly Asn Asn Gly Glu Thr Tyr Asp Ser Ile Ile Ile Asp

360 365 370ctt ccc gac cca aac aac gac acc atg gcc agg ctg tat tca gaa gag 1267Leu Pro Asp Pro Asn Asn Asp Thr Met Ala Arg Leu Tyr Ser Glu Glu

375 380 385ttc tac acc ttg gcc cga gca cga ctg aac gaa caa ggc cgc atg gtg 1315Phe Tyr Thr Leu Ala Arg Ala Arg Leu Asn Glu Gln Gly Arg Met Val390 395 400 405gtg caa tcc tcc agc gcc tac acc act cca gat gtg ttc tgg cga gtt 1363Val Gln Ser Ser Ser Ala Tyr Thr Thr Pro Asp Val Phe Trp Arg Val

410 415 420gga gca acc ttg aaa tcg gcg ggc tgt gaa caa gtc atc cca tat cac 1411Gly Ala Thr Leu Lys Ser Ala Gly Cys Glu Gln Val Ile Pro Tyr His

425 430 435gtg cat gtt ccc aca ttt ggc gac tgg ggc ttc caa ctg tgt ggc cct 1459Val His Val Pro Thr Phe Gly Asp Trp Gly Phe Gln Leu Cys Gly Pro

440 445 450gcc gac atg gaa tta gag ctt cgg gaa gac acc ccg cca ctg act ttc 1507Ala Asp Met Glu Leu Glu Leu Arg Glu Asp Thr Pro Pro Leu Thr Phe

455 460 465ctt aat gat gaa gtt ctg gtg gct gct ggg gtg ttt ggg ttg gat aat 1555Leu Asn Asp Glu Val Leu Val Ala Ala Gly Val Phe Gly Leu Asp Asn470 475 480 485cag cct cgt gaa ttg gaa cct tcc acg ctg gat cat ccc cgc gtg gtg 1603Gln Pro Arg Glu Leu Glu Pro Ser Thr Leu Asp His Pro Arg Val Val

490 495 500gag gat ctg cgc aag gga tac cgc gaa tca ggc gac tagctgcaac 1649Glu Asp Leu Arg Lys Gly Tyr Arg Glu Ser Gly Asp

505510 gatgcgctgt gtg 1662<210>348<211>513<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>348Met Ser Asp Leu Gly Pro Ile Trp Arg Trp Leu Leu Leu Val Ser Val 151015 Ser Ile Cys Ala Ala Ser Gly Leu Val Tyr Glu Leu Ala Leu Val Ser

20 25 30Leu Ser Thr Ser Leu Asn Gly Gly Gly Ile Val Glu Thr Ser Leu Ile

35 40 45Val Ala Gly Tyr Val Ala Ala Leu Gly Leu Gly Ala Leu Leu Val Lys

50 55 60Pro Phe Leu Asn Trp Pro Ala Gln Thr Phe Leu Gly Val Glu Thr Leu 65 70 75 80Leu Gly Leu Ile Gly Gly Cys Ser Ala Leu Val Leu Tyr Phe ThrPhe

85 90 95Ala Thr Ile Gly Gln Ser Leu Trp Ile Leu Val Ile Ala Thr Ala Ala

100 105 110Ile Gly Ile Leu Val Gly Ala Glu Leu Pro Leu Leu Met Thr Met Ile

115 120 125Gln Gln Gly Arg Leu Ala Asp Ala Lys Thr Thr Gly Ser Leu Val Ala

130 135 140Thr Leu Asn Ala Ala Asp Tyr Leu Gly Ala Leu Leu Gly Gly Leu Ala145 150 155 160Trp Pro Phe Val Leu Leu Pro Trp Leu Gly Met Met Arg Gly Ala Ala

165 170 175Ala Ala Gly Met Ile Asn Leu Val Ala Ala Leu Phe Val Gly Cys Val

180 185 190Leu Leu Arg His Leu Leu Pro Arg Thr His Phe Phe Val Ser Val Val

195 200 205Ala Leu Leu Leu Ala Ile Ala Ala Leu Ala Thr Val Leu ValLys Ser

210 215 220Asp Gly Ile Val Ala Thr Ala Arg Ala Gln Leu Tyr Arg Asp Pro Val225 230 235 240Ile Tyr Ser His Gln Ser Asp Tyr Gln Asp Ile Val Val Thr Glu Arg

245 250 255Gly Lys Asp Arg Arg Leu Tyr Leu Asn Gly Gly Leu Gln Tyr Ser Thr

260 265 270Arg Asp Gln His Arg Tyr Thr Glu Ser Leu Val Tyr Pro Ser Leu Asn

275 280 285Pro Glu Ala Glu Ser Val Leu Ile Ile Gly Gly Gly Asp Gly Leu Ala

290 295 300Ala Arg Glu Leu Leu Arg Phe Pro Ser Met Gln IleThr Gln Val Glu305 310 315 320Leu Asp Pro Glu Val Ile Glu Val Ala Asn Thr Val Leu Arg Ser Asp

325 330 335Asn Gly Gly Ala Met Glu Asp Pro Arg Val Ser Ile Ile Val Asp Asp

340 345 350Ala Phe Thr Trp Leu Arg Ser Gly Gly Asn Asn Gly Glu Thr Tyr Asp

355 360 365Ser Ile Ile Ile Asp Leu Pro Asp Pro Asn Asn Asp Thr Met Ala Arg

370 375 380Leu Tyr Ser Glu Glu Phe Tyr Thr Leu Ala Arg Ala Arg Leu Asn Glu385 390 395 400Gln Gly Arg Met Val Val Gln Ser Ser Ser Ala Tyr Thr Thr Pro Asp

405 410 415Val Phe Trp Arg Val Gly Ala Thr Leu Lys Ser Ala Gly Cys Glu Gln

420 425 430Val Ile Pro Tyr His Val His Val Pro Thr Phe Gly Asp Trp Gly Phe

435 440 445Gln Leu Cys Gly Pro Ala Asp Met Glu Leu Glu Leu Arg Glu Asp Thr

450 455 460Pro Pro Leu Thr Phe Leu Asn Asp Glu Val Leu Val Ala Ala Gly Val465 470 475 480Phe Gly Leu Asp Asn Gln Pro Arg Glu Leu Glu Pro Ser Thr Leu Asp

485 490 495His Pro Arg Val Val Glu Asp Leu Arg Lys Gly Tyr Arg Glu Ser Gly

500505510 Asp<210>349<211>924<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<901><223>RXA01757<400>349cgcttattga acggatgcct ctcgatcaag ccaacgaggc tattgcacgt atttcagctg 60gtaaaccacg tttccgtatt gtcttggagc cgaattcata atg cca aca gca agc 115

Met Pro Thr Ala Ser

1 5cca att tat gat gtc gtt gtc gtc gga gcc ggc att tct ggc ctc atc 163Pro Ile Tyr Asp Val Val Val Val Gly Ala Gly Ile Ser Gly Leu Ile

10 15 20gcc acg caa ctg ttg gac cgc gca ggt cta aac atc aaa tgc ttc gaa 211Ala Thr Gln Leu Leu Asp Arg Ala Gly Leu Asn Ile Lys Cys Phe Glu

25 30 35gcc tgc tca aga gtt ggc ggc cga gca gtg tct gtc caa cag tcc gat 259Ala Cys Ser Arg Val Gly Gly Arg Ala Val Ser Val Gln Gln Ser Asp

40 45 50ttg ttc ctg gac ctc ggc gca aca tgg ttc tgg ctc aac gaa cca ctt 307Leu Phe Leu Asp Leu Gly Ala Thr Trp Phe Trp Leu Asn Glu Pro Leu

55 60 65gtg cag caa ctc gtc aat aat ctc ggc ctc ggc aca ttc cct cag gcc 355Val Gln Gln Leu Val Asn Asn Leu Gly Leu Gly Thr Phe Pro Gln Ala 70 75 80 85atc gag ggt gat gcg ctt ttt gag acg ctt gtc gac gcc ccg agc cgc 403Ile Glu Gly Asp Ala Leu Phe Glu Thr Leu Val Asp Ala Pro Ser Arg

90 95 100ctg cgg ggt aac ccc ata gac gct gct tca ggc agg ttc caa gca ggg 451Leu Arg Gly Asn Pro Ile Asp Ala Ala Ser Gly Arg Phe Gln Ala Gly

105 110 115gcc tcc tcg ctt gcg ctc ggg ctt gca gcc cag ctc aag cca gga gtt 499Ala Ser Ser Leu Ala Leu Gly Leu Ala Ala Gln Leu Lys Pro Gly Val

120 125 130tta gaa ctc ggg gac ccc gtc cat tct ctc agt gag gaa gat ggg gaa 547Leu Glu Leu Gly Asp Pro Val His Ser Leu Ser Glu Glu Asp Gly Glu

135 140 145atc gtt gtg aag tct tcc aaa cag att gtg agg gca aag cac gtc atc 595Ile Val Val Lys Ser Ser Lys Gln Ile Val Arg Ala Lys His Val Ile150 155 160 165att gcg gtt cca ccg gca ctc gct gcc gag ttg att ggt ttc acc cta 643Ile Ala Val Pro Pro Ala Leu Ala Ala Glu Leu Ile Gly Phe Thr Leu

170 175 180gat tta cca gct gac gtg cga aaa gca gcg cat cca caa cat ata gct 691Asp Leu Pro Ala Asp Val Arg Lys Ala Ala His Pro Gln His Ile Ala

185 190 195gtg atg aat tgg gca aag gag aaa tac acc tta ccc aca caa gcc gca 739Val Met Asn Trp Ala Lys Glu Lys Tyr Thr Leu Pro Thr Gln Ala Ala

200 205 210tcg gct ggg ggt ttt ggg cat gag ctg ttc caa caa cca ctc gga cat 787Ser Ala Gly Gly Phe Gly His Glu Leu Phe Gln Gln Pro Leu Gly His

215 220 225ggg cga att cat tgg gca tca acg gaa gtt gcc act gag ttt ggt gga 835Gly Arg Ile His Trp Ala Ser Thr Glu Val Ala Thr Glu Phe Gly Gly230 235 240 245cac ctt gaa ggc gca gtt cgt gca gga att cag gct gcg ctt caa aca 883His Leu Glu Gly Ala Val Arg Ala Gly Ile Gln Ala Ala Leu Gln Thr

250 255 260gga ttt aat cta aaa tct taaacctcgt attttccctg ata 924Gly Phe Asn Leu Lys Ser

265<210>350<211>267<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>350Met Pro Thr Ala Ser Pro Ile Tyr Asp Val Val Val Val Gly Ala Gly 151015Ile Ser Gly Leu Ile Ala Thr Gln Leu Leu Asp Arg Ala Gly Leu Asn

20 25 30Ile Lys Cys Phe Glu Ala Cys Ser Arg Val Gly Gly Arg Ala Val Ser

35 40 45Val Gln Gln Ser Asp Leu Phe Leu Asp Leu Gly Ala Thr Trp Phe Trp

50 55 60Leu Asn Glu Pro Leu Val Gln Gln Leu Val Asn Asn Leu Gly Leu Gly 65 70 75 80Thr Phe Pro Gln Ala Ile Glu Gly Asp Ala Leu Phe Glu Thr Leu Val

85 90 95Asp Ala Pro Ser Arg Leu Arg Gly Asn Pro Ile Asp Ala Ala Ser Gly

100 105 110Arg Phe Gln Ala Gly Ala Ser Ser Leu Ala Leu Gly Leu Ala Ala Gln

115 120 125Leu Lys Pro Gly Val Leu Glu Leu Gly Asp Pro Val His Ser Leu Ser

130 135 140Glu Glu Asp Gly Glu Ile Val Val Lys Ser Ser Lys Gln Ile Val Arg145 150 155 160Ala Lys His Val Ile Ile Ala Val Pro Pro Ala Leu Ala Ala Glu Leu

165 170 175Ile Gly Phe Thr Leu Asp Leu Pro Ala Asp Val Arg Lys Ala Ala His

180 185 190Pro Gln His Ile Ala Val Met Asn Trp Ala Lys Glu Lys Tyr Thr Leu

195 200 205Pro Thr Gln Ala Ala Ser Ala Gly Gly Phe Gly His Glu Leu Phe Gln

210 215 220Gln Pro Leu Gly His Gly Arg Ile His Trp Ala Ser Thr Glu Val Ala225 230 235 240Thr Glu Phe Gly Gly HisLeu Glu Gly Ala Val Arg Ala Gly Ile Gln

245 250 255Ala Ala Leu Gln Thr Gly Phe Asn Leu Lys Ser

260265<210>351<211>636<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (613)<223>RXA02159<400>351tgatggacca gcgtccaaag ttttcgatga agcagaaaac cgcctccacg ctcagaaagc 60actgctggtg tggctgctgg ccaaccagcc gaggtaagac atg tcc ctt ggc tca 115

Met Ser Leu Gly Ser

1 5acc ccg tca aca ccg gaa aac tta aat ccc gtg act cgc act gca cgc 163Thr Pro Ser Thr Pro Glu Asn Leu Asn Pro Val Thr Arg Thr Ala Arg

10 15 20caa gct ctc att ttg cag att ttg gac aaa caa aaa gtc acc agc cag 211Gln Ala Leu Ile Leu Gln Ile Leu Asp Lys Gln Lys Val Thr Ser Gln

25 30 35gta caa ctg tct gaa ttg ctg ctg gat gaa ggc atc gat atc acc cag 259Val Gln Leu Ser Glu Leu Leu Leu Asp Glu Gly Ile Asp Ile Thr Gln

40 45 50gcc acc ttg tcc cga gat ctc gat gaa ctc ggt gca cgc aag gtt cgc 307Ala Thr Leu Ser Arg Asp Leu Asp Glu Leu Gly Ala Arg Lys Val Arg

55 60 65ccc gat ggg gga cgc gcc tac tac gcg gtc ggc cca gta gat agc atc 355Pro Asp Gly Gly Arg Ala Tyr Tyr Ala Val Gly Pro Val Asp Ser Ile 70 75 80 85gcc cgc gaa gat ctc cgg ggt ccg tcg gag aag ctg cgc cgc atg ctt 403Ala Arg Glu Asp Leu Arg Gly Pro Ser Glu Lys Leu Arg Arg Met Leu

90 95100gat gaa ctg ctg gtt tct aca gat cat tcc ggc aac atc gcg atg ctg 451Asp Glu Leu Leu Val Ser Thr Asp His Ser Gly Asn Ile Ala Met Leu

105 110 115cgc acc ccg ccg gga gct gcc cag tac ctg gca agt ttc atc gat agg 499Arg Thr Pro Pro Gly Ala Ala Gln Tyr Leu Ala Ser Phe Ile Asp Arg

120 125 130gtg ggg ctg aaa gaa gtc gtt ggc acc atc gct ggt gat gac acc gtt 547Val Gly Leu Lys Glu Val Val Gly Thr Ile Ala Gly Asp Asp Thr Val

135 140 145ttc gtt ctc gcc cgt gat ccg ctc aca ggt aaa gaa cta ggt gaa tta 595Phe Val Leu Ala Arg Asp Pro Leu Thr Gly Lys Glu Leu Gly Glu Leu150 155 160 165ctc agc ggg cgc acc act taaagcgccc ctagttcaag gct 636Leu Ser Gly Arg Thr Thr

170<210>352<211>171<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>352Met Ser Leu Gly Ser Thr Pro Ser Thr Pro Glu Asn Leu Asn Pro Val 151015 Thr Arg Thr Ala Arg Gln Ala Leu Ile Leu Gln Ile Leu Asp Lys Gln

20 25 30Lys Val Thr Ser Gln Val Gln Leu Ser Glu Leu Leu Leu Asp Glu Gly

35 40 45Ile Asp Ile Thr Gln Ala Thr Leu Ser Arg Asp Leu Asp Glu Leu Gly

50 55 60Ala Arg Lys Val Arg Pro Asp Gly Gly Arg Ala Tyr Tyr Ala Val Gly 65 70 75 80Pro Val Asp Ser Ile Ala Arg Glu Asp Leu Arg Gly Pro Ser Glu Lys

85 90 95Leu Arg Arg Met Leu Asp Glu Leu Leu Val Ser Thr Asp His Ser Gly

100105 110Asn Ile Ala Met Leu Arg Thr Pro Pro Gly Ala Ala Gln Tyr Leu Ala

115 120 125Ser Phe Ile Asp Arg Val Gly Leu Lys Glu Val Val Gly Thr Ile Ala

130 135 140Gly Asp Asp Thr Val Phe Val Leu Ala Arg Asp Pro Leu Thr Gly Lys145 150 155 160Glu Leu Gly Glu Leu Leu Ser Gly Arg Thr Thr

165170<210>353<211>414<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (391)<223>RXN02154<400>353cccagaacct cggcgaagtc agcgacaagc cagtcaaggt gagcttcacc ccagtgcttg 60caccgttacc tcgcgaattc tcaccactgc aaccgcacct ttg aaa gaa ggc gtt 115

Leu Lys Glu Gly Val

1 5acc gca gaa cag gct cgc gca gta tat gaa gag ttc tat gca cag gaa 163Thr Ala Glu Gln Ala Arg Ala Val Tyr Glu Glu Phe Tyr Ala Gln Glu

10 15 20acc ttc gtg cat gtt ctt cca gaa ggt gca cag cca caa acc caa gca 211Thr Phe Val His Val Leu Pro Glu Gly Ala Gln Pro Gln Thr Gln Ala

25 30 35gtt ctt ggc tcc aac atg tgc cac gtg cag gta gaa att gat gag gaa 259Val Leu Gly Ser Asn Met Cys His Val Gln Val Glu Ile Asp Glu Glu

40 45 50gca ggc aaa gtc ctt gtt acc tcc gca atc gat aac ctc acc aag gga 307Ala Gly Lys Val Leu Val Thr Ser Ala Ile Asp Asn Leu Thr Lys Gly

55 60 65act gcc ggc gcc gct gtt cag tgc atg aac tta agc gtt ggt ttt gat 355Thr Ala Gly Ala Ala Val Gln Cys MetAsn Leu Ser Val Gly Phe Asp 70 75 80 85gag gca gca ggc ctg cca cag gtc ggc gtc gca cct taaagtagcg 401Glu Ala Ala Gly Leu Pro Gln Val Gly Val Ala Pro

9095 ccttaaagcg gcg 414<414>354<211>97<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>354Leu Lys Glu Gly Val Thr Ala Glu Gln Ala Arg Ala Val Tyr Glu Glu 151015 Phe Tyr Ala Gln Glu Thr Phe Val His Val Leu Pro Glu Gly Ala Gln

20 25 30Pro Gln Thr Gln Ala Val Leu Gly Ser Asn Met Cys His Val Gln Val

35 40 45Glu Ile Asp Glu Glu Ala Gly Lys Val Leu Val Thr Ser Ala Ile Asp

50 55 60Asn Leu Thr Lys Gly Thr Ala Gly Ala Ala Val Gln Cys Met Asn Leu 65 70 75 80Ser Val Gly Phe Asp Glu Ala Ala Gly Leu Pro Gln Val Gly Val Ala

859095 Pro<210>355<211>1302<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1279)<223>RXS00147<400>355attgcatata atgcaatgaa ttgaataaac tacattcagg gttatcaacc agccaatttc 60ttttaaaaag gcagacacac gaaaggcgac aacagtcacc gtg agt aaa gac acc 115

Val Ser Lys Asp Thr

1 5acc acc tac cag gga gtc acc gag atc gga tcc gtt ccg gca tac ctg 163Thr Thr Tyr Gln Gly Val Thr Glu Ile Gly Ser Val Pro Ala Tyr Leu

10 15 20gtt ctt gca gac gga cgt acc ttc acc gga ttt ggc ttt gga gct atc 211Val Leu Ala Asp Gly Arg Thr Phe Thr GlyPhe Gly Phe Gly Ala Ile

25 30 35ggc acc acc ctt ggt gag gca gtg ttc act acc gcc atg acc ggt tac 259Gly Thr Thr Leu Gly Glu Ala Val Phe Thr Thr Ala Met Thr Gly Tyr

40 45 50caa gaa acc atg acc gat cct tcc tat cac cgc cag att gtt gtg gct 307Gln Glu Thr Met Thr Asp Pro Ser Tyr His Arg Gln Ile Val Val Ala

55 60 65acc gca cca cag atc ggc aac acc ggc tgg aac gat gag gac aac gag 355Thr Ala Pro Gln Ile Gly Asn Thr Gly Trp Asn Asp Glu Asp Asn Glu 70 75 80 85tcc cgc gac ggc aag att tgg gtt gca ggc ctt gtt atc cgc gac ctc 403Ser Arg Asp Gly Lys Ile Trp Val Ala Gly Leu Val Ile Arg Asp Leu

90 95 100gca gca cgt gtg tcc aac tgg cgc gcc acc acc tcc ttg cag cag gaa 451Ala Ala Arg Val Ser Asn Trp Arg Ala Thr Thr Ser Leu Gln Gln Glu

105 110 115atg gca ggc cag ggc atc gtc ggc atc ggc gga atc gac acc cgc gca 499Met Ala Gly Gln Gly Ile Val Gly Ile Gly Gly Ile Asp Thr Arg Ala

120 125 130ctg gtt cgc cac ctg cgc aat gaa ggt tcc att gca gcg ggc atc ttc 547Leu Val Arg His Leu Arg Asn Glu Gly Ser Ile Ala Ala Gly Ile Phe

135 140 145tcc ggc gct gac gca cag cgc cca gtt gaa gaa ctc gta gag atc gtc 595Ser Gly Ala Asp Ala Gln Arg Pro Val Glu Glu Leu Val Glu Ile Val150 155 160 165aag aat cag cca gca atg acc ggc gca aac ctc tcc gtt gag gtc tct 643Lys Asn Gln Pro Ala Met Thr Gly Ala Asn Leu Ser Val Glu Val Ser

170 175 180gct gat gaa acc tac gtc atc gaa gct gaa ggc gaa gag cgc cac acc 691Ala Asp Glu Thr Tyr Val Ile Glu Ala Glu Gly Glu Glu Arg His Thr

185 190 195gtc gtg gcc tac gac ctg ggc att aag caa aac acc cca cgt cgt ttc 739Val Val Ala Tyr Asp Leu Gly Ile Lys Gln Asn Thr Pro Arg Arg Phe

200 205 210tct gca cgc ggt gtt cgc acc gtc atc gtg cct gct gaa acc cca ttc 787Ser Ala Arg Gly Val Arg Thr Val Ile Val Pro Ala Glu Thr Pro Phe

215 220 225gag gat atc aag cag tac aac cca tca ggc gtg ttc atc tcc aac ggc 835Glu Asp Ile Lys Gln Tyr Asn Pro Ser Gly Val Phe Ile Ser Asn Gly230 235 240 245cct ggc gat cct gca gca gca gac gtc atg gtt gat atc gtc cgc gaa 883Pro Gly Asp Pro Ala Ala Ala Asp Val Met Val Asp Ile Val Arg Glu

250 255 260gtt ctt gaa gcc gac att cca ttc ttt ggc atc tgc ttc ggc aac cag 931Val Leu Glu Ala Asp Ile Pro Phe Phe Gly Ile Cys Phe Gly Asn Gln

265 270 275att ctt ggc cgc gca ttc ggc atg gag acc tac aag ctg aag ttc ggc 979Ile Leu Gly Arg Ala Phe Gly Met Glu Thr Tyr Lys Leu Lys Phe Gly

280 285 290cac cgc ggc atc aac gtt cca gtg aag aac cac atc acc ggc aag atc 1027His Arg Gly Ile Asn Val Pro Val Lys Asn His Ile Thr Gly Lys Ile

295 300 305gac atc acc gcc cag aac cac ggc ttc gca ctc aag ggt gaa gca ggc 1075Asp Ile Thr Ala Gln Asn His Gly Phe Ala Leu Lys Gly Glu Ala Gly310 315 320 325cag gaa ttc gag acc gat ttc ggc act gca att gtc acc cac acc tgc 1123Gln Glu Phe Glu Thr Asp Phe Gly Thr Ala Ile Val Thr His Thr Cys

330 335 340ctc aac gac ggc gtc gtt gaa ggt att gcg ctg aag tcc gga cgc gca 1171Leu Asn Asp Gly Val Val Glu Gly Ile Ala Leu Lys Ser Gly Arg Ala

345 350 355tac tcc gtt cag tac cac cca gag gcc gct gcc ggc cca aat gat gca 1219Tyr Ser Val Gln Tyr His Pro Glu Ala Ala Ala Gly Pro Asn Asp Ala

360 365 370agc ccc ctg ttt gac cag ttt gtt gag ctg atg gat gca gac gct cag 1267Ser Pro Leu Phe Asp Gln Phe Val Glu Leu Met Asp Ala Asp Ala Gln

375380385 aag aaa ggc gca taaataacat gccaaagcgt tca 1302Lys Lys Gly Ala390<210>356<211>393<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>356Val Ser Lys Asp Thr Thr Thr Tyr Gln Gly Val Thr Glu Ile Gly Ser 151015 Val Pro Ala Tyr Leu Val Leu Ala Asp Gly Arg Thr Phe Thr Gly Phe

20 25 30Gly Phe Gly Ala Ile Gly Thr Thr Leu Gly Glu Ala Val Phe Thr Thr

35 40 45Ala Met Thr Gly Tyr Gln Glu Thr Met Thr Asp Pro Ser Tyr His Arg

50 55 60Gln Ile Val Val Ala Thr Ala Pro Gln Ile Gly Asn Thr Gly Trp Asn 65 70 75 80Asp Glu Asp Asn Glu Ser Arg Asp Gly Lys Ile Trp Val Ala Gly Leu

85 90 95Val Ile Arg Asp Leu Ala Ala Arg Val Ser Asn Trp Arg Ala Thr Thr

100 105 110Ser Leu Gln Gln Glu Met Ala Gly Gln Gly Ile Val Gly Ile Gly Gly

115 120 125Ile Asp Thr Arg Ala Leu Val ArgHis Leu Arg Asn Glu Gly Ser Ile

130 135 140Ala Ala Gly Ile Phe Ser Gly Ala Asp Ala Gln Arg Pro Val Glu Glu145 150 155 160Leu Val Glu Ile Val Lys Asn Gln Pro Ala Met Thr Gly Ala Asn Leu

165 170 175Ser Val Glu Val Ser Ala Asp Glu Thr Tyr Val Ile Glu Ala Glu Gly

180 185 190Glu Glu Arg His Thr Val Val Ala Tyr Asp Leu Gly Ile Lys Gln Asn

195 200 205Thr Pro Arg Arg Phe Ser Ala Arg Gly Val Arg Thr Val Ile Val Pro

210 215 220Ala Glu Thr Pro Phe Glu Asp Ile Lys Gln Tyr Asn Pro Ser Gly Val225 230 235 240Phe Ile Ser Asn Gly Pro Gly Asp Pro Ala Ala Ala Asp Val Met Val

245 250 255Asp Ile Val Arg Glu Val Leu Glu Ala Asp Ile Pro Phe Phe Gly Ile

260 265 270Cys Phe Gly Asn Gln Ile Leu Gly Arg Ala Phe Gly Met Glu Thr Tyr

275 280 285Lys Leu Lys Phe Gly His Arg Gly Ile Asn Val Pro Val Lys Asn His

290 295 300Ile Thr Gly Lys Ile Asp Ile Thr Ala Gln Asn His Gly Phe Ala Leu305 310 315 320Lys Gly Glu Ala Gly Gln Glu Phe Glu Thr Asp Phe Gly Thr Ala Ile

325 330 335Val Thr His Thr Cys Leu Asn Asp Gly Val Val Glu Gly Ile Ala Leu

340 345 350Lys Ser Gly Arg Ala Tyr Ser Val Gln TyrHis Pro Glu Ala Ala Ala

355 360 365Gly Pro Asn Asp Ala Ser Pro Leu Phe Asp Gln Phe Val Glu Leu Met

370375380 Asp Ala Asp Ala Gln Lys Lys Gly Ala 385390<210>357<211>924<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).)

Met Thr Gln Phe Glu

1 5aac gcg caa gta ctt aaa gag aac atc gaa aac caa cgc gag cag atc 163Asn Ala Gln Val Leu Lys Glu Asn Ile Glu Asn Gln Arg Glu Gln Ile

10 15 20ttt acc cag ttg aaa gaa att gtg tct ttc aac tcc gtg cac agc gat 211Phe Thr Gln Leu Lys Glu Ile Val Ser Phe Asn Ser Val His Ser Asp

25 30 35cca aac cta ctg gag gac tac gcc ggc gcg aaa gaa tgg gta aaa gaa 259Pro Asn Leu Leu Glu Asp Tyr Ala Gly Ala Lys Glu Trp Val Lys Glu

40 45 50aca ctg acc aac gca ggt ctc acc gtc agc gaa ttc gct gcc gaa gat 307Thr Leu Thr Asn Ala Gly Leu Thr Val Ser Glu Phe Ala Ala Glu Asp

55 60 65gga acc acc aac ttc atc ggc acc cgc aag ggc tcc gaa ggt gca cca 355Gly Thr Thr Asn Phe Ile Gly Thr Arg Lys Gly Ser Glu Gly Ala Pro 70 75 80 85aag gta ctg ctg tac agc cac ttc gac gtt gtc cca tcc ggc cct ttg 403Lys Val Leu Leu Tyr Ser His Phe Asp Val Val Pro Ser Gly Pro Leu

90 95 100gat ctc tgg gac acc aat cct ttt gaa ctc acc gag cgc gac gct ggc 451Asp Leu Trp Asp Thr Asn Pro Phe Glu Leu Thr Glu Arg Asp AlaGly

105 110 115cac ggc acc cgc tgg tac ggc cgc ggc gcc gct gac tgc aag ggc aac 499His Gly Thr Arg Trp Tyr Gly Arg Gly Ala Ala Asp Cys Lys Gly Asn

120 125 130ctg gtc atg cac ctc gca gca ctg cgc gcc gtc gaa gcc agc ggc gac 547Leu Val Met His Leu Ala Ala Leu Arg Ala Val Glu Ala Ser Gly Asp

135 140 145acc aca ctc aac ctc acc tac gtg gtc gag ggc tcc gag gaa atg gga 595Thr Thr Leu Asn Leu Thr Tyr Val Val Glu Gly Ser Glu Glu Met Gly150 155 160 165ggc gga gcg ctc agc gcg ctc atc aag gac aag cct gag ctt ttc gac 643Gly Gly Ala Leu Ser Ala Leu Ile Lys Asp Lys Pro Glu Leu Phe Asp

170 175 180gca gat gtc atc ttg att gca gac agc gga aac gct tcc gtg ggc acc 691Ala Asp Val Ile Leu Ile Ala Asp Ser Gly Asn Ala Ser Val Gly Thr

185 190 195cca acc ttg acc act acc ctg cgc ggt ggc gga cag gtc acc gtc acc 739Pro Thr Leu Thr Thr Thr Leu Arg Gly Gly Gly Gln Val Thr Val Thr

200 205 210gtg gac acc ctt gaa ggc gct gtt cac tcc ggc cag aac ggt ggc gct 787Val Asp Thr Leu Glu Gly Ala Val His Ser Gly Gln Asn Gly Gly Ala

215 220 225gcc cca gat gct gtt gct gct ctc gtg cgc gtt ctg gat act ttg cgc 835Ala Pro Asp Ala Val Ala Ala Leu Val Arg Val Leu Asp Thr Leu Arg230 235 240 245gat gaa cac gga cgc acc gtt atc gac ggc tgt caa cac cac cgc aaa 883Asp Glu His Gly Arg Thr Val Ile Asp Gly Cys Gln His His Arg Lys

250 255 260ctg gaa ggg cga gcc tta tgatccagag actttccgca gcg 924Leu Glu Gly Arg Ala Leu

265<210>358<211>267<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>358Met Thr Gln Phe Glu Asn Ala Gln Val Leu Lys Glu Asn Ile Glu Asn 151015 Gln Arg Glu Gln Ile Phe Thr Gln Leu Lys Glu Ile Val Ser Phe Asn

20 25 30Ser Val His Ser Asp Pro Asn Leu Leu Glu Asp Tyr Ala Gly Ala Lys

35 40 45Glu Trp Val Lys Glu Thr Leu Thr Asn Ala Gly Leu Thr Val Ser Glu

50 55 60Phe Ala Ala Glu Asp Gly Thr Thr Asn Phe Ile Gly Thr Arg Lys Gly 65 70 75 80Ser Glu Gly Ala Pro Lys Val Leu Leu Tyr Ser His Phe Asp Val Val

85 90 95Pro Ser Gly Pro Leu Asp Leu Trp Asp Thr Asn Pro Phe Glu Leu Thr

100 105 110Glu Arg Asp Ala Gly His Gly Thr Arg Trp Tyr Gly Arg Gly Ala Ala

115 120 125Asp Cys Lys Gly Asn Leu Val Met His Leu Ala Ala Leu Arg Ala Val

130 135 140Glu Ala Ser Gly Asp Thr Thr Leu Asn Leu Thr Tyr Val Val Glu Gly145 150 155 160Ser Glu Glu Met Gly Gly Gly Ala Leu Ser Ala Leu Ile Lys Asp Lys

165 170 175Pro Glu Leu Phe Asp Ala Asp Val Ile Leu Ile Ala Asp Ser Gly Asn

180 185 190Ala Ser Val Gly Thr Pro Thr Leu Thr Thr Thr Leu Arg Gly Gly Gly

195 200205Gln Val Thr Val Thr Val Asp Thr Leu Glu Gly Ala Val His Ser Gly

210 215 220Gln Asn Gly Gly Ala Ala Pro Asp Ala Val Ala Ala Leu Val Arg Val225 230 235 240Leu Asp Thr Leu Arg Asp Glu His Gly Arg Thr Val Ile Asp Gly Cys

245 250 255Gln His His Arg Lys Leu Glu Gly Arg Ala Leu

260265<210>359<211>627<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (604)<223>RXS00906<400>359accgtggaca cccttgaagg cgctgttcac tccggccaga acggtggcgc tgccccagat 60gctgttgctg ctctcgtgcg cgttctggat actttgcgcg atg aac acg gac gca 115

Met Asn Thr Asp Ala

1 5ccg tta tcg acg gct gtc aac acc acc gca aac tgg aag ggc gag cct 163Pro Leu Ser Thr Ala Val Asn Thr Thr Ala Asn Trp Lys Gly Glu Pro

l0 15 20tat gat cca gag act ttc cgc agc gat gcc ggc atc ctc gac ggt gta 211Tyr Asp Pro Glu Thr Phe Arg Ser Asp Ala Gly Ile Leu Asp Gly Val

25 30 35gac atc atg ggc gac ggc gac aac cca gca agc atg ctg tgg tcc agg 259Asp Ile Met Gly Asp Gly Asp Asn Pro Ala Ser Met Leu Trp Ser Arg

40 45 50cct gca atc tcc atc acc gga ttc act tcc acc cca gtg gca gaa gca 307Pro Ala Ile Ser Ile Thr Gly Phe Thr Ser Thr Pro Val Ala Glu Ala

55 60 65ctc aac gca gtg ccc gca acg gcg tcc gcc aag cta aac ctt cgc gtg 355Leu Asn Ala Val Pro Ala Thr Ala Ser Ala Lys Leu Asn Leu Arg Val 70 75 80 85cca gca ggc ctg gaa gca aac gat gtg gcc gag aag ctg aag cag cac 403Pro Ala Gly Leu Glu Ala Asn Asp Val Ala Glu Lys Leu Lys Gln His

90 95 100ctg atc aat cac aca cct tgg ggc gca aag atc acg gtg gag atc gat 451Leu Ile Asn His Thr Pro Trp Gly Ala Lys Ile Thr Val Glu Ile Asp

105 110 115gac att aac caa ccg ttc tcc acc gat att acc ggc cct gca atg tcc 499Asp Ile Asn Gln Pro Phe Ser Thr Asp Ile Thr Gly Pro Ala Met Ser

120 125 130acc ctg gcg tcc tgc ctg agc gct gcg tac gag ggc aag gat ctt gtc 547Thr Leu Ala Ser Cys Leu Ser Ala Ala Tyr Glu Gly Lys Asp Leu Val

135140145 acc gaa ggc agc ggc gga tcc att cca ctg tgt acc gaa ctg att gag 595Thr Glu Gly Ser Gly Gly Ser Ile Pro Leu Cys Thr Glu Leu Ile Glu 150155160165 gtc aac cca taagcagaat tggcactcta cgg 627Val Asn Pro<210>360<211>168<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>360Met Asn Thr Asp Ala Pro Leu Ser Thr Ala Val Asn Thr Thr Ala Asn 151015 Trp Lys Gly Glu Pro Tyr Asp Pro Glu Thr Phe Arg Ser Asp Ala Gly

20 25 30Ile Leu Asp Gly Val Asp Ile Met Gly Asp Gly Asp Asn Pro Ala Ser

35 40 45Met Leu Trp Ser Arg Pro Ala Ile Ser Ile Thr Gly Phe Thr Ser Thr

50 55 60Pro Val Ala Glu Ala Leu Asn Ala Val Pro Ala Thr Ala Ser Ala Lys 65 70 75 80Leu Asn Leu Arg Val Pro Ala Gly Leu Glu Ala Asn Asp Val Ala Glu

85 9095Lys Leu Lys Gln His Leu Ile Asn His Thr Pro Trp Gly Ala Lys Ile

100 105 110Thr Val Glu Ile Asp Asp Ile Asn Gln Pro Phe Ser Thr Asp Ile Thr

115 120 125Gly Pro Ala Met Ser Thr Leu Ala Ser Cys Leu Ser Ala Ala Tyr Glu

130 135 140Gly Lys Asp Leu Val Thr Glu Gly Ser Gly Gly Ser Ile Pro Leu Cys145 150 155 160Thr Glu Leu Ile Glu Val Asn Pro

165<210>361<211>246<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (223)<223>RXS00907<400>361cctgagcgct gcgtacgagg gcaaggatct tgtcaccgaa ggcagcggcg gatccattcc 60actgtgtacc gaactgattg aggtcaaccc ataagcagaa ttg gca ctc tac ggt 115

Leu Ala Leu Tyr Gly

1 5gtg gaa gaa ccc ctc acc gtt atc cac tcc gct aat gaa tct gtt gac 163Val Glu Glu Pro Leu Thr Val Ile His Ser Ala Asn Glu Ser Val Asp

10 15 20ccc aat gag att cgc gat atc gcc acc gca gaa gca ttg ttc ctg ctc 211Pro Asn Glu Ile Arg Asp Ile Ala Thr Ala Glu Ala Leu Phe Leu Leu

25 30 35aac tac acc aag tagacccaaa agcaggcgtt aac 246Asn Tyr Thr Lys

40<210>362<211>41<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>362Leu Ala Leu Tyr Gly Val Glu Glu Pro Leu Thr Val Ile His Ser Ala 151015 Asn Glu Ser Val Asp Pro Asn Glu Ile Arg Asp Ile Ala Thr Ala Glu

20 25 30Ala Leu Phe Leu Leu Asn Tyr Thr Lys

3540<210>363<211>1281<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1258)<223>RXS02001<400>363gcggtttcgt catggataag gactgtgttc gggaccattg cgatactcgt gtcaaaaggc 60gatagtccag catagaccgt gctttatcga aggtgaaccc atg ccc gtt atc aat 115

Met Pro Val Ile Asn

1 5agt atc gcc agt ttt tcc gac gag atg acc cgc tgg cgg cgt cac ctg 163Ser Ile Ala Ser Phe Ser Asp Glu Met Thr Arg Trp Arg Arg His Leu

10 15 20cat caa aac ccc gaa atc agc ttt gat tgt gtg gaa act gcg gcc ttc 211His Gln Asn Pro Glu Ile Ser Phe Asp Cys Val Glu Thr Ala Ala Phe

25 30 35gtg gcc gag cag ctg cgc agc ttc ggg gtg gat gaa att cac acc ggc 259Val Ala Glu Gln Leu Arg Ser Phe Gly Val Asp Glu Ile His Thr Gly

40 45 50atc gcg aaa acc ggt atc atc gcc ctg att cac ggg cgc gag gct ggc 307Ile Ala Lys Thr Gly Ile Ile Ala Leu Ile His Gly Arg Glu Ala Gly

55 60 65ccc gtc gtc ggc ctg cgc gcc gat atg gac gcg ctg ccg ctg acc gag 355Pro Val Val Gly Leu Arg Ala Asp Met Asp Ala Leu Pro Leu Thr Glu 70 75 80 85att acc ggc gtc gac tat gcc tcg acc acc ccc gga aaa atg cac gcc 403Ile Thr Gly Val Asp Tyr Ala Ser Thr Thr Pro Gly Lys Met His Ala

90 95 100tgc ggc cac gac ggc cac acg acc atg ctg ctg ggc gcc gcc aaa tat 451CysGly His Asp Gly His Thr Thr Met Leu Leu Gly Ala Ala Lys Tyr

105 110 115ctg gcc gag acg cgc aat ttc gca ggt acc gtc gcg ctg atc ttc cag 499Leu Ala Glu Thr Arg Asn Phe Ala Gly Thr Val Ala Leu Ile Phe Gln

120 125 130cct gcg gaa gaa aac ggc ggc ggc gcg ggc gtt atg gtc gat gaa ggc 547Pro Ala Glu Glu Asn Gly Gly Gly Ala Gly Val Met Val Asp Glu Gly

135 140 145gtc ctc gac cgc ttt gcc atc gcc gaa gtc tac gcc ctg cac aac cag 595Val Leu Asp Arg Phe Ala Ile Ala Glu Val Tyr Ala Leu His Asn Gln150 155 160 165ccc ggc ctg ccg ctt ggc cat ttt atg acg aca gcc ggc ccg atc atg 643Pro Gly Leu Pro Leu Gly His Phe Met Thr Thr Ala Gly Pro Ile Met

170 175 180gcc gct gtc gac acg ttc gac atc aac att acc gga cgc ggc ggc cac 691Ala Ala Val Asp Thr Phe Asp Ile Asn Ile Thr Gly Arg Gly Gly His

185 190 195ggt gcc aaa ccg cac caa acc cgc gac ccc atc gtc gca gcc gtc gga 739Gly Ala Lys Pro His Gln Thr Arg Asp Pro Ile Val Ala Ala Val Gly

200 205 210att gtc caa gcg ttt caa acg ata gtc agc cgg aat cac aat ccg gtc 787Ile Val Gln Ala Phe Gln Thr Ile Val Ser Arg Asn His Asn Pro Val

215 220 225gag gac ctt gtc gtg tcg gtc acg caa atc cac acc ggc agc gcc gat 835Glu Asp Leu Val Val Ser Val Thr Gln Ile His Thr Gly Ser Ala Asp230 235 240 245aat atc atc ccc gaa acc gcc tat atc aac ggc act gtc cgc acc ttc 883Asn Ile Ile Pro Glu Thr Ala Tyr Ile Asn Gly Thr Val Arg Thr Phe

250255 260aac aaa gac gtg cag gcc atg gtc atc acg cgg atg gaa gaa atc gtc 931Asn Lys Asp Val Gln Ala Met Val Ile Thr Arg Met Glu Glu Ile Val

265 270 275gcg ggc caa gct gca gcc tat ggg gtc gag gcg acg ctg acc tac aac 979Ala Gly Gln Ala Ala Ala Tyr Gly Val Glu Ala Thr Leu Thr Tyr Asn

280 285 290cgc aac tat ccc gcc acc att aac gac gcc gcc aaa gcc gcc atc gct 1027Arg Asn Tyr Pro Ala Thr Ile Asn Asp Ala Ala Lys Ala Ala Ile Ala

295 300 305gcc gaa gtc gcg ggc gag gtc ggc ctc ggg gtc aac ccg aac ggc tcg 1075Ala Glu Val Ala Gly Glu Val Gly Leu Gly Val Asn Pro Asn Gly Ser310 315 320 325cgc ggg atg ggg gcc gag gat ttc tcg tat ttc ctc gaa aag cgc ccg 1123Arg Gly Met Gly Ala Glu Asp Phe Ser Tyr Phe Leu Glu Lys Arg Pro

330 335 340ggt gcc tac ctg ttc gtc ggt aat ggc gac agc gcg ggc ctt cac aac 1171Gly Ala Tyr Leu Phe Val Gly Asn Gly Asp Ser Ala Gly Leu His Asn

345 350 355ccc gcc tat aat ttc aac gac gag gcc gcg ccc tac ggc gca tcg ttc 1219Pro Ala Tyr Asn Phe Asn Asp Glu Ala Ala Pro Tyr Gly Ala Ser Phe

360 365 370ttg gcc cgc atg gca gaa cgc ccc ttg ccg tta aag ggc tgatccatgg 1268Leu Ala Arg Met Ala Glu Arg Pro Leu Pro Leu Lys Gly

375380385 cgctcgaaga tgc 1281<210>364<211>386<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>364Met Pro Val Ile Asn Ser Ile Ala Set Phe Ser Asp Glu Met Thr Arg 151015 Trp Arg Arg His Leu His Gln Asn Pro Glu Ile Ser Phe Asp Cys Val

20 25 30Glu Thr Ala Ala Phe Val Ala Glu Gln Leu Arg Ser Phe Gly Val Asp

35 40 45Glu Ile His Thr Gly Ile Ala Lys Thr Gly Ile Ile Ala Leu Ile His

50 55 60Gly Arg Glu Ala Gly Pro Val Val Gly Leu Arg Ala Asp Met Asp Ala 65 70 75 80Leu Pro Leu Thr Glu Ile Thr Gly Val Asp Tyr Ala Ser Thr Thr Pro

85 90 95Gly Lys Met His Ala Cys Gly His Asp Gly His Thr Thr Met Leu Leu

100 105 110Gly Ala Ala Lys Tyr Leu Ala Glu Thr Arg Asn Phe Ala Gly Thr Val

115 120 125Ala Leu Ile Phe Gln Pro Ala Glu Glu Asn Gly Gly Gly Ala Gly Val

130 135 140Met Val Asp Glu Gly Val Leu Asp Arg Phe Ala Ile Ala Glu Val Tyr145 150 155 160Ala Leu His Asn Gln Pro Gly Leu Pro Leu Gly His Phe Met Thr Thr

165 170 175Ala Gly Pro Ile Met Ala Ala Val Asp Thr Phe Asp Ile Asn Ile Thr

180 185 190Gly Arg Gly Gly His Gly Ala Lys Pro His Gln Thr Arg Asp Pro Ile

195 200 205Val Ala Ala Val Gly Ile Val Gln Ala Phe Gln Thr Ile Val Ser Arg

210 215 220Asn His Asn Pro Val Glu Asp Leu Val Val Ser Val Thr Gln Ile His225 230 235 240Thr Gly Ser Ala Asp Asn Ile Ile Pro Glu Thr Ala Tyr Ile Asn Gly

245250 255Thr Val Arg Thr Phe Asn Lys Asp Val Gln Ala Met Val Ile Thr Arg

260 265 270Met Glu Glu Ile Val Ala Gly Gln Ala Ala Ala Tyr Gly Val Glu Ala

275 280 285Thr Leu Thr Tyr Asn Arg Asn Tyr Pro Ala Thr Ile Asn Asp Ala Ala

290 295 300Lys Ala Ala Ile Ala Ala Glu Val Ala Gly Glu Val Gly Leu Gly Val305 310 315 320Asn Pro Asn Gly Ser Arg Gly Met Gly Ala Glu Asp Phe Ser Tyr Phe

325 330 335Leu Glu Lys Arg Pro Gly Ala Tyr Leu Phe Val Gly Asn Gly Asp Ser

340 345 350Ala Gly Leu His Asn Pro Ala Tyr Asn Phe Asn Asp Glu Ala Ala Pro

355 360 365Tyr Gly Ala Ser Phe Leu Ala Arg Met Ala Glu Arg Pro Leu Pro Leu

370375380 Lys Gly385<210>365<211>1386<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1363)<223>RXS02101<400>365gccatggaat gctccgttga acgcaacagc cttaaataca atcccctcct ataagccaag 60agttttagtg tcgctgcgca ggtactctac tatctaatcc atg agc cgc att tca 115

Met Ser Arg Ile Ser

1 5gaa ctt cta aac aat cat ggt gtt gat ctg tcg tgg caa gag gcc gca 163Glu Leu Leu Asn Asn His Gly Val Asp Leu Ser Trp Gln Glu Ala Ala

10 15 20tat cag gat ttc cac gaa cat cct gag ctc tcc ggc ttc gaa tca gag 211Tyr Gln Asp Phe His Glu His Pro Glu LeuSer Gly Phe Glu Ser Glu

25 30 35acc gca gat cgc att cag aaa tac ctc gag cgt ttt gat tgt gag gtg 259Thr Ala Asp Arg Ile Gln Lys Tyr Leu Glu Arg Phe Asp Cys Glu Val

40 45 50att cca aat gtt ggc ggt tac ggc att ctg gcc gtg ttc cga aat ggg 307Ile Pro Asn Val Gly Gly Tyr Gly Ile Leu Ala Val Phe Arg Asn Gly

55 60 65tcg aca gat cct ggt gcc cct gtt gcg tta atg cgc gca gat ttc gat 355Ser Thr Asp Pro Gly Ala Pro Val Ala Leu Met Arg Ala Asp Phe Asp 70 75 80 85ggc ctt ccc gtc aag gaa atc acc gga gtt ccg ttt gct tcc act cgt 403Gly Leu Pro Val Lys Glu Ile Thr Gly Val Pro Phe Ala Ser Thr Arg

90 95 100atg cgt ccg cat gat ggg gca aat gtc cat gtc atg cac gca tgc ggc 451Met Arg Pro His Asp Gly Ala Asn Val His Val Met His Ala Cys Gly

105 110 115cac gat gtc cac gtc acc gcg ctg ctt ggt gcg tgt gcc att tta gat 499His Asp Val His Val Thr Ala Leu Leu Gly Ala Cys Ala Ile Leu Asp

120 125 130gag cgt cgc gat gca tgg gaa ggc acg ttc atc gcg ttg ttc cag cca 547Glu Arg Arg Asp Ala Trp Glu Gly Thr Phe Ile Ala Leu Phe Gln Pro

135 140 145tcg gag gaa aac tcc caa ggc gct aac aag atg gtc gcc ggc ggt tta 595Ser Glu Glu Asn Ser Gln Gly Ala Asn Lys Met Val Ala Gly Gly Leu150 155 160 165gtt gat ctg atc cca cgc cct gat gtg tgc ttt ggc cag cat gta gtc 643Val Asp Leu Ile Pro Arg Pro Asp Val Cys Phe Gly Gln His Val Val

170 175 180ccc ggt gct gca gga acc gtg atg agc atg cct ggc ggt gct ctc gct 691Pro Gly Ala Ala Gly Thr Val Met Ser Met Pro Gly Gly Ala Leu Ala

185 190 195gcc tgc gat tcc att gaa atc cgc att cag ggt cgc agc gcc cat ggt 739Ala Cys Asp Ser Ile Glu Ile Arg Ile Gln Gly Arg Ser Ala His Gly

200 205 210tcc atg cct cat aat tcc atc gat ccc act tat gtt gca gcg atg att 787Ser Met Pro His Asn Ser Ile Asp Pro Thr Tyr Val Ala Ala Met Ile

215 220 225gtc gtg cga ctc caa gga atc gtg ggc cgc gag gtt tct cca gag gat 835Val Val Arg Leu Gln Gly Ile Val Gly Arg Glu Val Ser Pro Glu Asp230 235 240 245ttc gcc gtt att tct gtg ggc acc ctc cag tcg ggc aac acc aac aac 883Phe Ala Val Ile Ser Val Gly Thr Leu Gln Ser Gly Asn Thr Asn Asn

250 255 260acc att cca gca agt gct cgt ttg gtg ttg aac tgc cgt ttc tac aac 931Thr Ile Pro Ala Ser Ala Arg Leu Val Leu Asn Cys Arg Phe Tyr Asn

265 270 275gac aaa gtc aag cac aag gtc tac cga gcc atc gaa cgt gtt gtc cgt 979Asp Lys Val Lys His Lys Val Tyr Arg Ala Ile Glu Arg Val Val Arg

280 285 290ggt gaa tgc ctt gct tcc ggt att gag gaa gaa cct gtc att gag tac 1027Gly Glu Cys Leu Ala Ser Gly Ile Glu Glu Glu Pro Val Ile Glu Tyr

295 300 305ttc gcc cac ggt gat ctc acc aac aac acc cct gtt gtc ttc gat act 1075Phe Ala His Gly Asp Leu Thr Asn Asn Thr Pro Val Val Phe Asp Thr310 315 320 325gtg cgc cct gtc ttc gac gat gtt ttc ggc gag gat tct att gac gct 1123Val Arg Pro Val Phe Asp Asp Val Phe Gly Glu Asp Ser Ile Asp Ala

330 335 340tac cgg tgg act gcg tcg gag gat ttc ccc tcc att cct aag gca ttc 1171Tyr Arg Trp Thr Ala Ser Glu Asp Phe Pro Ser Ile Pro Lys Ala Phe

345 350 355aac agc cct tac ctg tac tgg acg att ggt gtc acg ccg cgc gat cag 1219Asn Ser Pro Tyr Leu Tyr Trp Thr Ile Gly Val Thr Pro Arg Asp Gln

360 365 370tgg aca gaa gcc gta gaa aga gac cgc gtg gca tcg gat gtg cca gcc 1267Trp Thr Glu Ala Val Glu Arg Asp Arg Val Ala Ser Asp Val Pro Ala

375 380 385aat cac atg gga gat ttc ctc cct gat tat gcg ccg acg atg tcc gct 1315Asn His Met Gly Asp Phe Leu Pro Asp Tyr Ala Pro Thr Met Ser Ala390 395 400 405gcc acc cgc gca gcc gca gcc gcg ctg ctg acc tac ttg gga act aac 1363Ala Thr Arg Ala Ala Ala Ala Ala Leu Leu Thr Tyr Leu Gly Thr Asn

410415420 taatcatcta gttttctgcg acg 1386<210>366<211>421<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>366Met Ser Arg Ile Ser Glu Leu Leu Asn Asn His Gly Val Asp Leu Ser 151015 Trp Gln Glu Ala Ala Tyr Gln Asp Phe His Glu His Pro Glu Leu Ser

20 25 30Gly Phe Glu Ser Glu Thr Ala Asp Arg Ile Gln Lys Tyr Leu Glu Arg

35 40 45Phe Asp Cys Glu Val Ile Pro Asn Val Gly Gly Tyr Gly Ile Leu Ala

50 55 60Val Phe Arg Asn Gly Ser Thr Asp Pro Gly Ala Pro Val Ala Leu Met 65 70 75 80Arg Ala Asp Phe Asp Gly Leu Pro Val Lys Glu Ile Thr Gly Val Pro

85 90 95Phe Ala Ser Thr Arg Met Arg Pro His Asp Gly Ala Asn Val His Val

100 105 110Met His Ala Cys Gly His Asp Val His Val Thr Ala Leu Leu Gly Ala

115 120 125Cys Ala Ile Leu Asp Glu Arg Arg Asp Ala Trp Glu Gly Thr Phe Ile

130 135 140Ala Leu Phe Gln Pro Ser Glu Glu Asn Ser Gln Gly Ala Asn Lys Met145 150 155 160Val Ala Gly Gly Leu Val Asp Leu Ile Pro Arg Pro Asp Val Cys Phe

165 170 175Gly Gln His Val Val Pro Gly Ala Ala Gly Thr Val Met Ser Met Pro

180 185 190Gly Gly Ala Leu Ala Ala Cys Asp Ser Ile Glu Ile Arg Ile Gln Gly

195 200 205Arg Ser Ala His Gly Ser Met Pro His Asn Ser Ile Asp Pro Thr Tyr

210 215 220Val Ala Ala Met Ile Val Val Arg Leu Gln Gly Ile Val Gly Arg Glu225 230 235 240Val Ser Pro Glu Asp Phe Ala Val Ile Ser Val Gly Thr Leu Gln Ser

245 250 255Gly Asn Thr Asn Asn Thr Ile Pro Ala Ser Ala Arg Leu Val Leu Asn

260 265 270Cys Arg Phe Tyr Asn Asp Lys Val Lys His Lys Val Tyr Arg Ala Ile

275 280 285Glu Arg Val Val Arg Gly Glu Cys Leu Ala Ser Gly Ile Glu Glu Glu

290 295 300Pro Val Ile Glu Tyr Phe Ala His Gly Asp Leu Thr Asn Asn Thr Pro305310 315 320Val Val Phe Asp Thr Val Arg Pro Val Phe Asp Asp Val Phe Gly Glu

325 330 335Asp Ser Ile Asp Ala Tyr Arg Trp Thr Ala Ser Glu Asp Phe Pro Ser

340 345 350Ile Pro Lys Ala Phe Asn Ser Pro Tyr Leu Tyr Trp Thr Ile Gly Val

355 360 365Thr Pro Arg Asp Gln Trp Thr Glu Ala Val Glu Arg Asp Arg Val Ala

370 375 380Ser Asp Val Pro Ala Asn His Met Gly Asp Phe Leu Pro Asp Tyr Ala385 390 395 400Pro Thr Met Ser Ala Ala Thr Arg Ala Ala Ala Ala Ala Leu Leu Thr

405 410 415Tyr Leu Gly Thr Asn

420<210>367<211>3462<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (3439)<223>RXS02234<400>367acccagaggc cgctgccggc ccaaatgatg caagccccct gtttgaccag tttgttgagc 60tgatggatgc agacgctcag aagaaaggcg cataaataac atg cca aag cgt tca 115

Met Pro Lys Arg Ser

1 5gat att aac cac gtc ctc gtc atc ggt tcc ggc ccc atc gtc att ggc 163Asp Ile Asn His Val Leu Val Ile Gly Ser Gly Pro Ile Val Ile Gly

10 15 20cag gca tgt gaa ttc gac tac tcc ggc acc cag gct tgc cgc gtg ctg 211Gln Ala Cys Glu Phe Asp Tyr Ser Gly Thr Gln Ala Cys Arg Val Leu

25 30 35aag gaa gag gga ctg cgc gtc acc ctc atc aac tcc aac cca gca acg 259Lys Glu Glu Gly Leu Arg Val Thr Leu Ile Asn Ser Asn Pro Ala Thr

40 45 50atc atg acc gac cca gaa atg gct gac cac acc tac gtg gag cca atc 307Ile Met Thr Asp Pro Glu Met Ala Asp His Thr Tyr Val Glu Pro Ile

55 60 65gag ccg gaa tac atc gac aag att ttc gct aag gaa atc gag cag ggc 355Glu Pro Glu Tyr Ile Asp Lys Ile Phe Ala Lys Glu Ile Glu Gln Gly 70 75 80 85cac cca atc gac gcc gtc ctg gca acc ctt ggt ggc cag act gca ctt 403His Pro Ile Asp Ala Val Leu Ala Thr Leu Gly Gly Gln Thr Ala Leu

90 95 100aac gca gct atc cag ctg gat cgc ctc ggc atc ctg gaa aag tac ggc 451Asn Ala Ala Ile Gln Leu Asp Arg Leu Gly Ile Leu Glu Lys Tyr Gly

105 110 115gtt gaa ctc atc ggt gca gac atc gat gcc att gag cgc ggc gaa gat 499Val Glu Leu Ile Gly Ala Asp Ile Asp Ala Ile Glu Arg Gly Glu Asp

120 125 130cgc cag aag ttc aag gat att gtc acc acc atc ggt ggc gaa tcc gcg 547Arg Gln Lys Phe Lys Asp Ile Val Thr Thr Ile Gly Gly Glu Ser Ala

135 140 145cgt tcc cgc gtc tgc cac aac atg gaa gaa gtc cac gag act gtc gca 595Arg Ser Arg Val Cys His Asn Met Glu Glu Val His Glu Thr Val Ala150 155 160 165gaa ctc ggc ctt cca gta gtc gtg cgt cca tcc ttc act atg ggt ggc 643Glu Leu Gly Leu Pro Val Val Val Arg Pro Ser Phe Thr Met Gly Gly

170 175 180ctg ggc tcc ggt ctt gca tac aac acc gaa gac ctt gag cgc atc gct 691Leu Gly Ser Gly Leu Ala Tyr Asn Thr Glu Asp Leu Glu Arg Ile Ala

185 190 195ggt ggc gga ctt gct gca tct cct gaa gca aac gtc ttg atc gaa gaa 739Gly Gly Gly Leu Ala Ala Ser Pro Glu Ala Asn Val Leu Ile Glu Glu

200 205 210tcc atc ctt ggt tgg aag gaa ttc gag ctc gag ctc atg cgc gat acc 787Ser Ile Leu Gly Trp Lys Glu Phe Glu Leu Glu Leu Met Arg Asp Thr

215 220 225gca gac aac gtt gtg gtt atc tgc tcc att gaa aac gtc gac gca ctg 835Ala Asp Asn Val Val Val Ile Cys Ser Ile Glu Asn Val Asp Ala Leu230 235 240 245ggc gtg cac acc ggc gac tct gtc acc gtg gca cct gcc ctg acc ctg 883Gly Val His Thr Gly Asp Ser Val Thr Val Ala Pro Ala Leu Thr Leu

250 255 260act gac cgt gaa ttc cag aag atg cgc gat cag ggt atc gcc atc atc 931Thr Asp Arg Glu Phe Gln Lys Met Arg Asp Gln Gly Ile Ala Ile Ile

265 270 275cgc gag gtc ggc gtg gac acc ggt gga tgt aac atc cag ttc gcc atc 979Arg Glu Val Gly Val Asp Thr Gly Gly Cys Asn Ile Gln Phe Ala Ile

280 285 290aac cca gtt gat ggc cgc atc atc acc att gag atg aac cca cgt gtg 1027Asn Pro Val Asp Gly Arg Ile Ile Thr Ile Glu Met Asn Pro Arg Val

295 300 305tct cgt tcc tcc gct ctg gca tcc aag gca acg ggc ttc cca att gcc 1075Ser Arg Ser Ser Ala Leu Ala Ser Lys Ala Thr Gly Phe Pro Ile Ala310 315 320 325aag atg gct gcc aag ctg gct atc gga tac acc ctg gat gag atc acc 1123Lys Met Ala Ala Lys Leu Ala Ile Gly Tyr Thr Leu Asp Glu Ile Thr

330 335 340aac gac atc act ggt gaa acc cca gct gcg ttt gag ccc acc atc gac 1171Asn Asp Ile Thr Gly Glu Thr Pro Ala Ala Phe Glu Pro Thr Ile Asp

345 350 355tac gtc gtg gtc aag gcc cca cgc ttt gct ttc gag aag ttt gtc ggc 1219Tyr Val Val Val Lys Ala Pro Arg Phe Ala Phe Glu Lys Phe Val Gly

360 365 370gct gat gac act ttg acc acc acc atg aag tcc gtc ggt gag gtc atg 1267Ala Asp Asp Thr Leu Thr Thr Thr Met Lys Ser Val Gly Glu Val Met

375 380 385tcc ctg ggc cgc aac tac att gca gca ctg aac aag gca ctg cgt tcc 1315Ser Leu Gly Arg Asn Tyr Ile Ala Ala Leu Asn Lys Ala Leu Arg Ser390 395 400 405ctg gaa acc aag cag cag ggt ttc tgg acc aag cct gat gag ttc ttc 1363Leu Glu Thr Lys Gln Gln Gly Phe Trp Thr Lys Pro Asp Glu Phe Phe

410 415 420gca ggg gag cgc gct acc gat aag gca gct gtt ctg gaa gat ctc aag 1411Ala Gly Glu Arg Ala Thr Asp Lys Ala Ala Val Leu Glu Asp Leu Lys

425 430 435cgc cca acc gaa ggc cgc ctc tac gac gtt gag ctg gca atg cgc ctt 1459Arg Pro Thr Glu Gly Arg Leu Tyr Asp Val Glu Leu Ala Met Arg Leu

440 445 450ggc gca agc gtg gaa gaa ctc tac gaa gca tct tct att gat cct tgg 1507Gly Ala Ser Val Glu Glu Leu Tyr Glu Ala Ser Ser Ile Asp Pro Trp

455 460 465ttc ctc gcc gag ctt gaa gct ctc gtg cag ttc cgc cag aag ctc gtt 1555Phe Leu Ala Glu Leu Glu Ala Leu Val Gln Phe Arg Gln Lys Leu Val470 475 480 485gac gca cca ttc cta aac gaa gat ctc ctg cgc gaa gca aag ttc atg 1603Asp Ala Pro Phe Leu Asn Glu Asp Leu Leu Arg Glu Ala Lys Phe Met

490 495 500ggt ctg tcc gac etg cag atc gca gcc ctt cgc cca gag ttc gct ggc 1651Gly Leu Ser Asp Leu Gln Ile Ala Ala Leu Arg Pro Glu Phe Ala Gly

505 510 515gaa gac ggc gta cgc acc ttg cgt ctg tcc cta ggc atc cgc cca gta 1699Glu Asp Gly Val Arg Thr Leu Arg Leu Ser Leu Gly Ile Arg Pro Val

520 525 530ttc aag act gtg gat acc tgt gca gca gag ttt gaa gct aag act ccg 1747Phe Lys Thr Val Asp Thr Cys Ala Ala Glu Phe Glu Ala Lys Thr Pro

535 540 545tac cac tac tcc gca tac gag ctg gat cca gca gct gag tct gag gtc 1795Tyr His Tyr Ser Ala Tyr Glu Leu Asp Pro Ala Ala Glu Ser Glu Val550 555 560 565gca cca cag act gag cgt gaa aag gtc ctg atc ttg ggc tcc ggt cca 1843Ala Pro Gln Thr Glu Arg Glu Lys Val Leu Ile Leu Gly Ser Gly Pro

570 575 580aac cgc atc ggc cag ggc atc gag ttc gac tac tcc tgt gtt cac gca 1891Asn Arg Ile Gly Gln Gly Ile Glu Phe Asp Tyr Ser Cys Val His Ala

585 590 595gct ctt gag ctc tcc cgc gtc ggc tac gaa act gtc atg gtc aac tgc 1939Ala Leu Glu Leu Ser Arg Val Gly Tyr Glu Thr Val Met Val Asn Cys

600 605 610aac cca gag acc gtg tcc acc gac tac gac acc gct gac cgc ctg tac 1987Asn Pro Glu Thr Val Ser Thr Asp Tyr Asp Thr Ala Asp Arg Leu Tyr

615 620 625ttc gag cca ctg acc ttc gaa gac gtc atg gag gtc tac cac gct gag 2035Phe Glu Pro Leu Thr Phe Glu Asp Val Met Glu Val Tyr His Ala Glu630 635 640 645gcg cag tcc ggc acc gtc gca ggt gtt atc gtc cag ctt ggt ggc cag 2083Ala Gln Ser Gly Thr Val Ala Gly Val Ile Val Gln Leu Gly Gly Gln

650 655 660act cct ctg ggc ttg gca gat cgt ttg aag aag gct ggc gtc cct gtc 2131Thr Pro Leu Gly Leu Ala Asp Arg Leu Lys Lys Ala Gly Val Pro Val

665 670 675att ggt acc tcc cca gag gca atc gac atg gct gag gac cgt ggc gag 2179Ile Gly Thr Ser Pro Glu Ala Ile Asp Met Ala Glu Asp Arg Gly Glu

680 685 690ttc ggt gca ctg ctg aac cgc gag cag ctt cct gct cca gca ttc ggc 2227Phe Gly Ala Leu Leu Asn Arg Glu Gln Leu Pro Ala Pro Ala Phe Gly

695 700 705acc gca acc tct ttc gaa gag gct cgc aca gta gcc gat gag atc agc 2275Thr Ala Thr Ser Phe Glu Glu Ala Arg Thr Val Ala Asp Glu Ile Ser710 715 720 725tac cca gtg ctg gtt cgc cct tcc tac gtc ttg ggt ggc cgt ggc atg 2323Tyr Pro Val Leu Val Arg Pro Ser Tyr Val Leu Gly Gly Arg Gly Met

730 735 740gag att gtc tac gat gag gct tcc ctc gag gat tac atc aac cgc gca 2371Glu Ile Val Tyr Asp Glu Ala Ser Leu Glu Asp Tyr Ile Asn Arg Ala

745 750 755act gag ttg tct tct gac cac cca gtg ctg gtt gac cgc ttc cta gac 2419Thr Glu Leu Ser Ser Asp His Pro Val Leu Val Asp Arg Phe Leu Asp

760 765 770aac gct att gag atc gac gtc gac gca ctg tgc gac ggc gac gag gtc 2467Asn Ala Ile Glu Ile Asp Val Asp Ala Leu Cys Asp Gly Asp Glu Val

775 780 785tac ctg gca ggc gtc atg gag cac atc gag gaa gcc ggc att cac tcc 2515Tyr Leu Ala Gly Val Met Glu His Ile Glu Glu Ala Gly Ile His Ser790 795 800 805ggt gac tcc gca tgt gca ctt cct cca atg act ttg ggc gca cag gac 2563Gly Asp Ser Ala Cys Ala Leu Pro Pro Met Thr Leu Gly Ala Gln Asp

810 815 820atc gag aag gtc cgc gaa gca acc aag aag ctg gct ctg ggc atc ggt 2611Ile Glu Lys Val Arg Glu Ala Thr Lys Lys Leu Ala Leu Gly Ile Gly

825 830 835gta cag ggc ctg atg aac gtc cag tac gca ctc aag gac gac atc ctc 2659Val Gln Gly Leu Met Asn Val Gln Tyr Ala Leu Lys Asp Asp Ile Leu

840 845 850tac gtc atc gag gca aac cca cgt gca tcc cgc acc gtg ccg ttc gtc 2707Tyr Val Ile Glu Ala Asn Pro Arg Ala Ser Arg Thr Val Pro Phe Val

855 860 865tcc aag gca acg ggc gtc aac ctg gcc aag gca gca tcc cgt atc gca 2755Ser Lys Ala Thr Gly Val Asn Leu Ala Lys Ala Ala Ser Arg Ile Ala870 875 880 885gtg ggc gcc acc atc aag gat ctc caa gat gag ggc atg att cct acc 2803Val Gly Ala Thr Ile Lys Asp Leu Gln Asp Glu Gly Met Ile Pro Thr

890 895 900gag tac gac ggc ggc tcc ttg cca ctg gac gct cca atc gct gtg aag 2851Glu Tyr Asp Gly Gly Ser Leu Pro Leu Asp Ala Pro Ile Ala Val Lys

905 910 915gaa gca gtg ttg ccg ttc aac cgc ttc cgt cgc cca gat gga aag acc 2899Glu Ala Val Leu Pro Phe Asn Arg Phe Arg Arg Pro Asp Gly Lys Thr

920 925 930ctg gac acc ctg ctt tcc cca gag atg aag tcc act ggc gag gtc atg 2947Leu Asp Thr Leu Leu Ser Pro Glu Met Lys Ser Thr Gly Glu Val Met

935 940 945ggc ttggcc aac aac ttc ggc gct gca tat gca aag gct gaa gct ggc 2995Gly Leu Ala Asn Asn Phe Gly Ala Ala Tyr Ala Lys Ala Glu Ala Gly950 955 960 965gcg ttt ggt gca ttg cca acc gaa ggc acc gtc ttc gtg acc gtg gct 3043Ala Phe Gly Ala Leu Pro Thr Glu Gly Thr Val Phe Val Thr Val Ala

970 975 980aac cgc gac aag cgc acc ctg atc ctg cca atc cag cgc ctg gcg ttg 3091Asn Arg Asp Lys Arg Thr Leu Ile Leu Pro Ile Gln Arg Leu Ala Leu

985 990 995atg ggc tac aag atc ctc gcc acc gaa ggc acc gca ggc atg ctg cgc 3139Met Gly Tyr Lys Ile Leu Ala Thr Glu Gly Thr Ala Gly Met Leu Arg

1000 1005 1010cgc aac ggc att gag tgt gaa gtt gtg ctc aag gct tcc gac atc cgc 3187Arg Asn Gly Ile Glu Cys Glu Val Val Leu Lys Ala Ser Asp Ile Arg

1015 1020 1025gaa ggt gta gag ggc aag tcc atc gtg gat cgt atc cgc gaa ggc gaa 3235Glu Gly Val Glu Gly Lys Ser Ile Val Asp Arg Ile Arg Glu Gly Glu1030 1035 1040 1045gtt gac ctc atc ctc aac acc cca gct ggt tct gct ggc gct cgc cac 3283Val Asp Leu Ile Leu Asn Thr Pro Ala Gly Ser Ala Gly Ala Arg His

1050 1055 1060gat ggc tac gat atc cgc gca gca gca gtg acc gtg ggt gtt ccg ctg 3331Asp Gly Tyr Asp Ile Arg Ala Ala Ala Val Thr Val Gly Val Pro Leu

1065 1070 1075atc acc act gtt cag ggt gtc acc gca gct gtc cag ggc ata gag gcc 3379Ile Thr Thr Val Gln Gly Val Thr Ala Ala Val Gln Gly Ile Glu Ala

1080 1085 1090ctg cgt gag ggc gtt gtc agc gtc cgc gcg ctg cag gaa ctc gac cac 3427Leu Arg Glu Gly Val Val Ser Val Arg Ala Leu Gln Glu Leu Asp His

109511001105 gca gtc aag gct taagccctat gacattcggc gag 3462Ala Val Lys Ala1110<210>368<211>1113<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>368Met Pro Lys Arg Ser Asp Ile Asn His Val Leu Val Ile Gly Ser Gly 151015 Pro Ile Val Ile Gly Gln Ala Cys Glu Phe Asp Tyr Ser Gly Thr Gln

20 25 30Ala Cys Arg Val Leu Lys Glu Glu Gly Leu Arg Val Thr Leu Ile Asn

35 40 45Ser Asn Pro Ala Thr Ile Met Thr Asp Pro Glu Met Ala Asp His Thr

50 55 60Tyr Val Glu Pro Ile Glu Pro Glu Tyr Ile Asp Lys Ile Phe Ala Lys 65 70 75 80Glu Ile Glu Gln Gly His Pro Ile Asp Ala Val Leu Ala Thr Leu Gly

85 90 95Gly Gln Thr Ala Leu Asn Ala Ala Ile Gln Leu Asp Arg Leu Gly Ile

100 105 110Leu Glu Lys Tyr Gly Val Glu Leu Ile Gly Ala Asp Ile Asp Ala Ile

115 120 125Glu Arg Gly Glu Asp Arg Gln Lys Phe Lys Asp Ile Val Thr Thr Ile

130 135 140Gly Gly Glu Ser Ala Arg Ser Arg Val Cys His Asn Met Glu Glu Val145 150 155 160His Glu Thr Val Ala Glu Leu Gly Leu Pro Val Val Val Arg Pro Ser

165 170 175Phe Thr Met Gly Gly Leu Gly Ser Gly Leu Ala Tyr Asn Thr Glu Asp

180 185 190Leu Glu Arg Ile Ala Gly Gly Gly Leu Ala Ala Ser Pro Glu Ala Asn

195 200 205Val Leu Ile Glu Glu Ser Ile Leu Gly Trp Lys Glu Phe Glu Leu Glu

210 215 220Leu Met Arg Asp Thr Ala Asp Asn Val Val Val Ile Cys Ser Ile Glu225 230 235 240Asn Val Asp Ala Leu Gly Val His Thr Gly Asp Ser Val Thr Val Ala

245 250 255Pro Ala Leu Thr Leu Thr Asp Arg Glu Phe Gln Lys Met Arg Asp Gln

260 265 270Gly Ile Ala Ile Ile Arg Glu Val Gly Val Asp Thr Gly Gly Cys Asn

275 280 285Ile Gln Phe Ala Ile Asn Pro Val Asp Gly Arg Ile Ile Thr Ile Glu

290 295 300Met Asn Pro Arg Val Ser Arg Ser Ser Ala Leu Ala Ser Lys Ala Thr305 310 315 320Gly Phe Pro Ile Ala Lys Met Ala Ala Lys Leu Ala Ile Gly Tyr Thr

325 330 335Leu Asp Glu Ile Thr Asn Asp Ile Thr Gly Glu Thr Pro Ala Ala Phe

340 345 350Glu Pro Thr Ile Asp Tyr Val Val Val Lys Ala Pro Arg Phe Ala Phe

355 360 365Glu Lys Phe Val Gly Ala Asp Asp Thr Leu Thr Thr Thr Met Lys Ser

370 375 380Val Gly Glu Val Met Ser Leu Gly Arg Asn Tyr Ile Ala Ala Leu Asn385 390 395 400Lys Ala Leu Arg Ser Leu Glu Thr Lys Gln Gln Gly Phe Trp Thr Lys

405 410 415Pro Asp Glu Phe Phe Ala Gly Glu Arg Ala Thr Asp Lys Ala Ala Val

420425 430Leu Glu Asp Leu Lys Arg Pro Thr Glu Gly Arg Leu Tyr Asp Val Glu

435 440 445Leu Ala Met Arg Leu Gly Ala Ser Val Glu Glu Leu Tyr Glu Ala Ser

450 455 460Ser Ile Asp Pro Trp Phe Leu Ala Glu Leu Glu Ala Leu Val Gln Phe465 470 475 480Arg Gln Lys Leu Val Asp Ala Pro Phe Leu Asn Glu Asp Leu Leu Arg

485 490 495Glu Ala Lys Phe Met Gly Leu Ser Asp Leu Gln Ile Ala Ala Leu Arg

500 505 510Pro Glu Phe Ala Gly Glu Asp Gly Val Arg Thr Leu Arg Leu Ser Leu

515 520 525Gly Ile Arg Pro Val Phe Lys Thr Val Asp Thr Cys Ala Ala Glu Phe

530 535 540Glu Ala Lys Thr Pro Tyr His Tyr Ser Ala Tyr Glu Leu Asp Pro Ala545 550 555 560Ala Glu Ser Glu Val Ala Pro Gln Thr Glu Arg Glu Lys Val Leu Ile

565 570 575Leu Gly Ser Gly Pro Asn Arg Ile Gly Gln Gly Ile Glu Phe Asp Tyr

580 585 590Ser Cys Val His Ala Ala Leu Glu Leu Ser Arg Val Gly Tyr Glu Thr

595 600 605Val Met Val Asn Cys Asn Pro Glu Thr Val Ser Thr Asp Tyr Asp Thr

610 615 620Ala Asp Arg Leu Tyr Phe Glu Pro Leu Thr Phe Glu Asp Val Met Glu625 630 635 640Val Tyr His Ala Glu Ala Gln Ser Gly Thr Val Ala Gly Val Ile Val

645 650 655Gln Leu Gly Gly Gln Thr Pro Leu Gly Leu Ala Asp Arg Leu Lys Lys

660 665 670Ala Gly Val Pro Val Ile Gly Thr Ser Pro Glu Ala Ile Asp Met Ala

675 680 685Glu Asp Arg Gly Glu Phe Gly Ala Leu Leu Asn Arg Glu Gln Leu Pro

690 695 700Ala Pro Ala Phe Gly Thr Ala Thr Ser Phe Glu Glu Ala Arg Thr Val705 710 715 720Ala Asp Glu Ile Ser Tyr Pro Val Leu Val Arg Pro Ser Tyr Val Leu

725 730 735Gly Gly Arg Gly Met Glu Ile Val Tyr Asp Glu Ala Ser Leu Glu Asp

740 745 750Tyr Ile Asn Arg Ala Thr Glu Leu Ser Ser Asp His Pro Val Leu Val

755 760 765Asp Arg Phe Leu Asp Asn Ala Ile Glu Ile Asp Val Asp Ala Leu Cys

770 775 780Asp Gly Asp Glu Val Tyr Leu Ala Gly Val Met Glu His Ile Glu Glu785 790 795 800Ala Gly Ile His Ser Gly Asp Ser Ala Cys Ala Leu Pro Pro Met Thr

805 810 815Leu Gly Ala Gln Asp Ile Glu Lys Val Arg Glu Ala Thr Lys Lys Leu

820 825 830Ala Leu Gly Ile Gly Val Gln Gly Leu Met Asn Val Gln Tyr Ala Leu

835 840 845Lys Asp Asp Ile Leu Tyr Val Ile Glu Ala Asn Pro Arg Ala Ser Arg

850 855 860Thr Val Pro Phe Val Ser Lys Ala Thr Gly Val Asn Leu Ala Lys Ala865 870 875 880Ala Ser Arg Ile Ala Val Gly Ala Thr Ile Lys Asp Leu Gln Asp Glu

885 890 895Gly Met Ile Pro Thr Glu Tyr Asp Gly Gly Ser Leu Pro Leu Asp Ala

900 905 910Pro Ile Ala Val Lys Glu Ala Val Leu Pro Phe Asn Arg Phe Arg Arg

915 920 925Pro Asp Gly Lys Thr Leu Asp Thr Leu Leu Ser Pro Glu Met Lys Ser

930 935 940Thr Gly Glu Val Met Gly Leu Ala Asn Asn Phe Gly Ala Ala Tyr Ala945 950 955 960Lys Ala Glu Ala Gly Ala Phe Gly Ala Leu Pro Thr Glu Gly Thr Val

965 970 975Phe Val Thr Val Ala Asn Arg Asp Lys Arg Thr Leu Ile Leu Pro Ile

980 985 990Gln Arg Leu Ala Leu Met Gly Tyr Lys Ile Leu Ala Thr Glu Gly Thr

995 1000 1005Ala Gly Met Leu Arg Arg Asn Gly Ile Glu Cys Glu Val Val Leu Lys

1010 1015 1020Ala Ser Asp Ile Arg Glu Gly Val Glu Gly Lys Ser Ile Val Asp Arg1025 1030 1035 1040Ile Arg Glu Gly Glu Val Asp Leu Ile Leu Asn Thr Pro Ala Gly Ser

1045 1050 1055Ala Gly Ala Arg His Asp Gly Tyr Asp Ile Arg Ala Ala Ala Val Thr

1060 1065 1070Val Gly Val Pro Leu Ile Thr Thr Val Gln Gly Val Thr Ala Ala Val

1075 1080 1085Gln Gly Ile Glu Ala Leu Arg Glu Gly Val Val Ser Val Arg Ala Leu

109010951100 Gln Glu Leu Asp His Ala ValLys Ala 11051110<210>369<211>3221<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) } (3198)<223>FRXA02234<400>369ggc tcc aac cca gca acg atc atg acc gac cca gaa atg gct gac cac 48Gly Ser Asn Pro Ala Thr Ile Met Thr Asp Pro Glu Met Ala Asp His l 51015 acc tac gtg gag cca atc gag ccg gaa tac atc gac aag att ttc gct 96Thr Tyr Val Glu Pro Ile Glu Pro Glu Tyr Ile Asp Lys Ile Phe Ala<400>369ggc tcc aac cca gca acg atc atg acc gac cca gaa atg gct gac cac

20 25 30aag gaa atc gag cag ggc cac cca atc gac gcc gtc ctg gca acc ctt 144Lys Glu Ile Glu Gln Gly His Pro Ile Asp Ala Val Leu Ala Thr Leu

35 40 45ggt ggc cag act gca ctt aac gca gct atc cag ctg gat cgc ctc ggc 192Gly Gly Gln Thr Ala Leu Asn Ala Ala Ile Gln Leu Asp Arg Leu Gly

50 55 60atc ctg gaa aag tac ggc gtt gaa ctc atc ggt gca gac atc gat gcc 240Ile Leu Glu Lys Tyr Gly Val Glu Leu Ile Gly Ala Asp Ile Asp Ala 65 70 75 80att gag cgc ggc gaa gat cgc cag aag ttc aag gat att gtc acc acc 288Ile Glu Arg Gly Glu Asp Arg Gln Lys Phe Lys Asp Ile Val Thr Thr

85 90 95atc ggt ggc gaa tcc gcg cgt tcc cgc gtc tgc cac aac atg gaa gaa 336Ile Gly Gly Glu Ser Ala Arg Ser Arg Val Cys His Asn Met Glu Glu

100 105 110gtc cac gag act gtc gca gaa ctc ggc ctt cca gta gtc gtg cgt cca 384Val His Glu Thr Val Ala Glu Leu Gly Leu Pro Val Val Val Arg Pro

115 120 125tcc ttc act atg ggt ggc ctg ggc tcc ggt ctt gca tac aac acc gaa 432Ser Phe Thr Met Gly Gly Leu Gly Ser Gly Leu Ala Tyr Asn Thr Glu

130 135 140gac ctt gag cgc atc gct ggt ggc gga ctt gct gca tct cct gaa gca 480Asp Leu Glu Arg Ile Ala Gly Gly Gly Leu Ala Ala Ser Pro Glu Ala145 150 155 160aac gtc ttg atc gaa gaa tcc atc ctt ggt tgg aag gaa ttc gag ctc 528Asn Val Leu Ile Glu Glu Ser Ile Leu Gly Trp Lys Glu Phe Glu Leu

165 170 175gag ctc atg cgc gat acc gca gac aac gtt gtg gtt atc tgc tcc att 576Glu Leu Met Arg Asp Thr Ala Asp Asn Val Val Val Ile Cys Ser Ile

180 185 190gaa aac gtc gac gca ctg ggc gtg cac acc ggc gac tct gtc acc gtg 624Glu Asn Val Asp Ala Leu Gly Val His Thr Gly Asp Ser Val Thr Val

195 200 205gca cct gcc ctg acc ctg act gac cgt gaa ttc cag aag atg cgc gat 672Ala Pro Ala Leu Thr Leu Thr Asp Arg Glu Phe Gln Lys Met Arg Asp

210 215 220cag ggt atc gcc atc atc cgc gag gtc ggc gtg gac acc ggt gga tgt 720Gln Gly Ile Ala Ile Ile Arg Glu Val Gly Val Asp Thr Gly Gly Cys225 230 235 240aac atc cag ttc gcc atc aac cca gtt gat ggc cgc atc atc acc att 768Asn Ile Gln Phe Ala Ile Asn Pro Val Asp Gly Arg Ile Ile Thr Ile

245 250 255gag atg aac cca cgt gtg tct cgt tcc tcc gct ctg gca tcc aag gca 816Glu Met Asn Pro Arg Val Ser Arg Ser Ser Ala Leu Ala Ser Lys Ala

260 265 270acg ggc ttc cca att gcc aag atg gct gcc aag ctg gct atc gga tac 864Thr Gly Phe Pro Ile Ala Lys Met Ala Ala Lys Leu Ala Ile Gly Tyr

275 280 285acc ctg gat gagatc acc aac gac atc act ggt gaa acc cca gct gcg 912Thr Leu Asp Glu Ile Thr Asn Asp Ile Thr Gly Glu Thr Pro Ala Ala

290 295 300ttt gag ccc acc atc gac tac gtc gtg gtc aag gcc cca cgc ttt gct 960Phe Glu Pro Thr Ile Asp Tyr Val Val Val Lys Ala Pro Arg Phe Ala305 310 315 320ttc gag aag ttt gtc ggc gct gat gac act ttg acc acc acc atg aag 1008Phe Glu Lys Phe Val Gly Ala Asp Asp Thr Leu Thr Thr Thr Met Lys

325 330 335tcc gtc ggt gag gtc atg tcc ctg ggc cgc aac tac att gca gca ctg 1056Ser Val Gly Glu Val Met Ser Leu Gly Arg Asn Tyr Ile Ala Ala Leu

340 345 350aac aag gca ctg cgt tcc ctg gaa acc aag cag cag ggt ttc tgg acc 1104Asn Lys Ala Leu Arg Ser Leu Glu Thr Lys Gln Gln Gly Phe Trp Thr

355 360 365aag cct gat gag ttc ttc gca ggg gag cgc gct acc gat aag gca gct 1152Lys Pro Asp Glu Phe Phe Ala Gly Glu Arg Ala Thr Asp Lys Ala Ala

370 375 380gtt ctg gaa gat ctc aag cgc cca acc gaa ggc cgc ctc tac gac gtt 1200Val Leu Glu Asp Leu Lys Arg Pro Thr Glu Gly Arg Leu Tyr Asp Val385 390 395 400gag ctg gca atg cgc ctt ggc gca agc gtg gaa gaa ctc tac gaa gca 1248Glu Leu Ala Met Arg Leu Gly Ala Ser Val Glu Glu Leu Tyr Glu Ala

405 410 415tct tct att gat cct tgg ttc ctc gcc gag ctt gaa gct ctc gtg cag 1296Ser Ser Ile Asp Pro Trp Phe Leu Ala Glu Leu Glu Ala Leu Val Gln

420 425 430ttc cgc cag aag ctc gtt gac gca cca ttc cta aac gaa gat ctc ctg 1344Phe Arg Gln Lys Leu Val Asp Ala Pro Phe Leu Asn GluAsp Leu Leu

435 440 445cgc gaa gca aag ttc atg ggt ctg tcc gac ctg cag atc gca gcc ctt 1392Arg Glu Ala Lys Phe Met Gly Leu Ser Asp Leu Gln Ile Ala Ala Leu

450 455 460cgc cca gag ttc gct ggc gaa gac ggc gta cgc acc ttg cgt ctg tcc 1440Arg Pro Glu Phe Ala Gly Glu Asp Gly Val Arg Thr Leu Arg Leu Ser465 470 475 480cta ggc atc cgc cca gta ttc aag act gtg gat acc tgt gca gca gag 1488Leu Gly Ile Arg Pro Val Phe Lys Thr Val Asp Thr Cys Ala Ala Glu

485 490 495ttt gaa gct aag act ccg tac cac tac tcc gca tac gag ctg gat cca 1536Phe Glu Ala Lys Thr Pro Tyr His Tyr Ser Ala Tyr Glu Leu Asp Pro

500 505 510gca gct gag tct gag gtc gca cca cag act gag cgt gaa aag gtc ctg 1584Ala Ala Glu Ser Glu Val Ala Pro Gln Thr Glu Arg Glu Lys Val Leu

515 520 525atc ttg ggc tcc ggt cca aac cgc atc ggc cag ggc atc gag ttc gac 1632Ile Leu Gly Ser Gly Pro Asn Arg Ile Gly Gln Gly Ile Glu Phe Asp

530 535 540tac tcc tgt gtt cac gca gct ctt gag ctc tcc cgc gtc ggc tac gaa 1680Tyr Ser Cys Val His Ala Ala Leu Glu Leu Ser Arg Val Gly Tyr Glu545 550 555 560act gtc atg gtc aac tgc aac cca gag acc gtg tcc acc gac tac gac 1728Thr Val Met Val Asn Cys Asn Pro Glu Thr Val Ser Thr Asp Tyr Asp

565 570 575acc gct gac cgc ctg tac ttc gag cca ctg acc ttc gaa gac gtc atg 1776Thr Ala Asp Arg Leu Tyr Phe Glu Pro Leu Thr Phe Glu Asp Val Met

580 585 590gag gtctac cac gct gag gcg cag tcc ggc acc gtc gca ggt gtt atc 1824Glu Val Tyr His Ala Glu Ala Gln Ser Gly Thr Val Ala Gly Val Ile

595 600 605gtc cag ctt ggt ggc cag act cct ctg ggc ttg gca gat cgt ttg aag 1872Val Gln Leu Gly Gly Gln Thr Pro Leu Gly Leu Ala Asp Arg Leu Lys

610 615 620aag gct ggc gtc cct gtc att ggt acc tcc cca gag gca atc gac atg 1920Lys Ala Gly Val Pro Val Ile Gly Thr Ser Pro Glu Ala Ile Asp Met625 630 635 640gct gag gac cgt ggc gag ttc ggt gca ctg ctg aac cgc gag cag ctt 1968Ala Glu Asp Arg Gly Glu Phe Gly Ala Leu Leu Asn Arg Glu Gln Leu

645 650 655cct gct cca gca ttc ggc acc gca acc tct ttc gaa gag gct cgc aca 2016Pro Ala Pro Ala Phe Gly Thr Ala Thr Ser Phe Glu Glu Ala Arg Thr

660 665 670gta gcc gat gag atc agc tac cca gtg ctg gtt cgc cct tcc tac gtc 2064Val Ala Asp Glu Ile Ser Tyr Pro Val Leu Val Arg Pro Ser Tyr Val

675 680 685ttg ggt ggc cgt ggc atg gag att gtc tac gat gag gct tcc ctc gag 2112Leu Gly Gly Arg Gly Met Glu Ile Val Tyr Asp Glu Ala Ser Leu Glu

690 695 700gat tac atc aac cgc gca act gag ttg tct tct gac cac cca gtg ctg 2160Asp Tyr Ile Asn Arg Ala Thr Glu Leu Ser Ser Asp His Pro Val Leu705 710 715 720gtt gac cgc ttc cta gac aac gct att gag atc gac gtc gac gca ctg 2208Val Asp Arg Phe Leu Asp Asn Ala Ile Glu Ile Asp Val Asp Ala Leu

725 730 735tgc gac ggc gac gag gtc tac ctg gca ggc gtc atg gag cac atc gag 2256Cys Asp Gly Asp Glu Val Tyr Leu Ala Gly Val Met Glu His Ile Glu

740 745 750gaa gcc ggc att cac tcc ggt gac tcc gca tgt gca ctt cct cca atg 2304Glu Ala Gly Ile His Ser Gly Asp Ser Ala Cys Ala Leu Pro Pro Met

755 760 765act ttg ggc gca cag gac atc gag aag gtc cgc gaa gca acc aag aag 2352Thr Leu Gly Ala Gln Asp Ile Glu Lys Val Arg Glu Ala Thr Lys Lys

770 775 780ctg gct ctg ggc atc ggt gta cag ggc ctg atg aac gtc cag tac gca 2400Leu Ala Leu Gly Ile Gly Val Gln Gly Leu Met Asn Val Gln Tyr Ala785 790 795 800ctc aag gac gac atc ctc tac gtc atc gag gca aac cca cgt gca tcc 2448Leu Lys Asp Asp Ile Leu Tyr Val Ile Glu Ala Asn Pro Arg Ala Ser

805 810 815cgc acc gtg ccg ttc gtc tcc aag gca acg ggc gtc aac ctg gcc aag 2496Arg Thr Val Pro Phe Val Ser Lys Ala Thr Gly Val Asn Leu Ala Lys

820 825 830gca gca tcc cgt atc gca gtg ggc gcc acc atc aag gat ctc caa gat 2544Ala Ala Ser Arg Ile Ala Val Gly Ala Thr Ile Lys Asp Leu Gln Asp

835 840 845gag ggc atg att cct acc gag tac gac ggc ggc tcc ttg cca ctg gac 2592Glu Gly Met Ile Pro Thr Glu Tyr Asp Gly Gly Ser Leu Pro Leu Asp

850 855 860gct cca atc gct gtg aag gaa gca gtg ttg ccg ttc aac cgc ttc cgt 2640Ala Pro Ile Ala Val Lys Glu Ala Val Leu Pro Phe Asn Arg Phe Arg865 870 875 880cgc cca gat gga aag acc ctg gac acc ctg ctt tcc cca gag atg aag 2688Arg Pro Asp Gly Lys Thr Leu Asp Thr Leu Leu Ser Pro Glu Met Lys

885 890 895tcc act ggc gag gtc atg ggc ttg gcc aac aac ttc ggc gct gca tat 2736Ser Thr Gly Glu Val Met Gly Leu Ala Asn Asn Phe Gly Ala Ala Tyr

900 905 910gca aag gct gaa gct ggc gcg ttt ggt gca ttg cca acc gaa ggc acc 2784Ala Lys Ala Glu Ala Gly Ala Phe Gly Ala Leu Pro Thr Glu Gly Thr

915 920 925gtc ttc gtg acc gtg gct aac cgc gac aag cgc acc ctg atc ctg cca 2832Val Phe Val Thr Val Ala Asn Arg Asp Lys Arg Thr Leu Ile Leu Pro

930 935 940atc cag cgc ctg gcg ttg atg ggc tac aag atc ctc gcc acc gaa ggc 2880Ile Gln Arg Leu Ala Leu Met Gly Tyr Lys Ile Leu Ala Thr Glu Gly945 950 955 960acc gca ggc atg ctg cgc cgc aac ggc att gag tgt gaa gtt gtg ctc 2928Thr Ala Gly Met Leu Arg Arg Asn Gly Ile Glu Cys Glu Val Val Leu

965 970 975aag gct tcc gac atc cgc gaa ggt gta gag ggc aag tcc atc gtg gat 2976Lys Ala Ser Asp Ile Arg Glu Gly Val Glu Gly Lys Ser Ile Val Asp

980 985 990cgt atc cgc gaa ggc gaa gtt gac ctc atc ctc aac acc cca gct ggt 3024Arg Ile Arg Glu Gly Glu Val Asp Leu Ile Leu Asn Thr Pro Ala Gly

995 1000 1005tct gct ggc gct cgc cac gat ggc tac gat atc cgc gca gca gca gtg 3072Ser Ala Gly Ala Arg His Asp Gly Tyr Asp Ile Arg Ala Ala Ala Val

1010 1015 1020acc gtg ggt gtt ccg ctg atc acc act gtt cag ggt gtc acc gca gct 3120Thr Val Gly Val Pro Leu Ile Thr Thr Val Gln Gly Val Thr Ala Ala1025 1030 1035 1040gtc cag ggc ata gag gcc ctg cgt gag ggc gtt gtc agc gtc cgc gcg 3168Val Gln Gly Ile Glu Ala Leu Arg Glu Gly ValVal Ser Val Arg Ala

1045 1050 1055ctg cag gaa ctc gac cac gca gtc aag gct taagccctat gacattcggc 3218Leu Gln Glu Leu Asp His Ala Val Lys Ala

10601065 gag 3221<210>370<211>1066<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>370Gly Ser Asn Pro Ala Thr Ile Met Thr Asp Pro Glu Met Ala Asp His 151015 Thr Tyr Val Glu Pro Ile Glu Pro Glu Tyr Ile Asp Lys Ile Phe Ala

20 25 30Lys Glu Ile Glu Gln Gly His Pro Ile Asp Ala Val Leu Ala Thr Leu

35 40 45Gly Gly Gln Thr Ala Leu Asn Ala Ala Ile Gln Leu Asp Arg Leu Gly

50 55 60Ile Leu Glu Lys Tyr Gly Val Glu Leu Ile Gly Ala Asp Ile Asp Ala 65 70 75 80Ile Glu Arg Gly Glu Asp Arg Gln Lys Phe Lys Asp Ile Val Thr Thr

85 90 95Ile Gly Gly Glu Ser Ala Arg Ser Arg Val Cys His Asn Met Glu Glu

100 105 110Val His Glu Thr Val Ala Glu Leu Gly Leu Pro Val Val Val Arg Pro

115 120 125Ser Phe Thr Met Gly Gly Leu Gly Ser Gly Leu Ala Tyr Asn Thr Glu

130 135 140Asp Leu Glu Arg Ile Ala Gly Gly Gly Leu Ala Ala Ser Pro Glu Ala145 150 155 160Asn Val Leu Ile Glu Glu Ser Ile Leu Gly Trp Lys Glu Phe Glu Leu

165 170 175Glu Leu Met Arg Asp Thr Ala Asp Asn Val Val Val Ile Cys Ser Ile

180185 190Glu Asn Val Asp Ala Leu Gly Val His Thr Gly Asp Ser Val Thr Val

195 200 205Ala Pro Ala Leu Thr Leu Thr Asp Arg Glu Phe Gln Lys Met Arg Asp

210 215 220Gln Gly Ile Ala Ile Ile Arg Glu Val Gly Val Asp Thr Gly Gly Cys225 230 235 240Asn Ile Gln Phe Ala Ile Asn Pro Val Asp Gly Arg Ile Ile Thr Ile

245 250 255Glu Met Asn Pro Arg Val Ser Arg Ser Ser Ala Leu Ala Ser Lys Ala

260 265 270Thr Gly Phe Pro Ile Ala Lys Met Ala Ala Lys Leu Ala Ile Gly Tyr

275 280 285Thr Leu Asp Glu Ile Thr Asn Asp Ile Thr Gly Glu Thr Pro Ala Ala

290 295 300Phe Glu Pro Thr Ile Asp Tyr Val Val Val Lys Ala Pro Arg Phe Ala305 310 315 320Phe Glu Lys Phe Val Gly Ala Asp Asp Thr Leu Thr Thr Thr Met Lys

325 330 335Ser Val Gly Glu Val Met Ser Leu Gly Arg Asn Tyr Ile Ala Ala Leu

340 345 350Asn Lys Ala Leu Arg Ser Leu Glu Thr Lys Gln Gln Gly Phe Trp Thr

355 360 365Lys Pro Asp Glu Phe Phe Ala Gly Glu Arg Ala Thr Asp Lys Ala Ala

370 375 380Val Leu Glu Asp Leu Lys Arg Pro Thr Glu Gly Arg Leu Tyr Asp Val385 390 395 400Glu Leu Ala Met Arg Leu Gly Ala Ser Val Glu Glu Leu Tyr Glu Ala

405 410 415Ser Ser Ile Asp Pro Trp Phe Leu Ala Glu Leu Glu Ala Leu Val Gln

420 425 430Phe Arg Gln Lys Leu Val Asp Ala Pro Phe Leu Asn Glu Asp Leu Leu

435 440 445Arg Glu Ala Lys Phe Met Gly Leu Ser Asp Leu Gln Ile Ala Ala Leu

450 455 460Arg Pro Glu Phe Ala Gly Glu Asp Gly Val Arg Thr Leu Arg Leu Ser465 470 475 480Leu Gly Ile Arg Pro Val Phe Lys Thr Val Asp Thr Cys Ala Ala Glu

485 490 495Phe Glu Ala Lys Thr Pro Tyr His Tyr Ser Ala Tyr Glu Leu Asp Pro

500 505 510Ala Ala Glu Ser Glu Val Ala Pro Gln Thr Glu Arg Glu Lys Val Leu

515 520 525Ile Leu Gly Ser Gly Pro Asn Arg Ile Gly Gln Gly Ile Glu Phe Asp

530 535 540Tyr Ser Cys Val His Ala Ala Leu Glu Leu Ser Arg Val Gly Tyr Glu545 550 555 560Thr Val Met Val Asn Cys Asn Pro Glu Thr Val Ser Thr Asp Tyr Asp

565 570 575Thr Ala Asp Arg Leu Tyr Phe Glu Pro Leu Thr Phe Glu Asp Val Met

580 585 590Glu Val Tyr His Ala Glu Ala Gln Ser Gly Thr Val Ala Gly Val Ile

595 600 605Val Gln Leu Gly Gly Gln Thr Pro Leu Gly Leu Ala Asp Arg Leu Lys

610 615 620Lys Ala Gly Val Pro Val Ile Gly Thr Ser Pro Glu Ala Ile Asp Met625 630 635 640Ala Glu Asp Arg Gly Glu Phe Gly Ala Leu Leu Asn Arg Glu Gln Leu

645 650 655Pro Ala Pro Ala Phe Gly Thr Ala Thr Ser Phe Glu Glu Ala Arg Thr

660 665 670Val Ala Asp Glu Ile Ser Tyr Pro Val Leu Val Arg Pro Ser Tyr Val

675 680 685Leu Gly Gly Arg Gly Met Glu Ile Val Tyr Asp Glu Ala Ser Leu Glu

690 695 700Asp Tyr Ile Asn Arg Ala Thr Glu Leu Ser Ser Asp His Pro Val Leu705 710 715 720Val Asp Arg Phe Leu Asp Asn Ala Ile Glu Ile Asp Val Asp Ala Leu

725 730 735Cys Asp Gly Asp Glu Val Tyr Leu Ala Gly Val Met Glu His Ile Glu

740 745 750Glu Ala Gly Ile His Ser Gly Asp Ser Ala Cys Ala Leu Pro Pro Met

755 760 765Thr Leu Gly Ala Gln Asp Ile Glu Lys Val Arg Glu Ala Thr Lys Lys

770 775 780Leu Ala Leu Gly Ile Gly Val Gln Gly Leu Met Asn Val Gln Tyr Ala785 790 795 800Leu Lys Asp Asp Ile Leu Tyr Val Ile Glu Ala Asn Pro Arg Ala Ser

805 810 815Arg Thr Val Pro Phe Val Ser Lys Ala Thr Gly Val Asn Leu Ala Lys

820 825 830Ala Ala Ser Arg Ile Ala Val Gly Ala Thr Ile Lys Asp Leu Gln Asp

835 840 845Glu Gly Met Ile Pro Thr Glu Tyr Asp Gly Gly Ser Leu Pro Leu Asp

850 855860Ala Pro Ile Ala Val Lys Glu Ala Val Leu Pro Phe Asn Arg Phe Arg865 870 875 880Arg Pro Asp Gly Lys Thr Leu Asp Thr Leu Leu Ser Pro Glu Met Lys

885 890 895Ser Thr Gly Glu Val Met Gly Leu Ala Asn Asn Phe Gly Ala Ala Tyr

900 905 910Ala Lys Ala Glu Ala Gly Ala Phe Gly Ala Leu Pro Thr Glu Gly Thr

915 920 925Val Phe Val Thr Val Ala Asn Arg Asp Lys Arg Thr Leu Ile Leu Pro

930 935 940Ile Gln Arg Leu Ala Leu Met Gly Tyr Lys Ile Leu Ala Thr Glu Gly945 950 955 960Thr Ala Gly Met Leu Arg Arg Asn Gly Ile Glu Cys Glu Val Val Leu

965 970 975Lys Ala Ser Asp Ile Arg Glu Gly Val Glu Gly Lys Ser Ile Val Asp

980 985 990Arg Ile Arg Glu Gly Glu Val Asp Leu Ile Leu Asn Thr Pro Ala Gly

995 1000 1005Ser Ala Gly Ala Arg His Asp Gly Tyr Asp Ile Arg Ala Ala Ala Val

1010 1015 1020Thr Val Gly Val Pro Leu Ile Thr Thr Val Gln Gly Val Thr Ala Ala1025 1030 1035 1040Val Gln Gly Ile Glu Ala Leu Arg Glu Gly Val Val Ser Val Arg Ala

1045 1050 1055Leu Gln Glu Leu Asp His Ala Val Lys Ala

10601065<210>371<211>1389<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1366)<223>RXS02565<400>371ggaaattcga tacagtgcga tgacgcgata ttagaaagaa aaagatgcgc tttacgacga 60aaccctcacc ctccttcagg aacttatccg caacgcctgc gtg aat gat cta acc 115

Val Asn Asp Leu Thr

1 5cca gat tca ggt cag gaa att aga aac gcg gaa agc cta gaa cgt ttc 163Pro Asp Ser Gly Gln Glu Ile Arg Asn Ala Glu Ser Leu Glu Arg Phe

10 15 20ttt gaa gga acc ccc aac gtt aaa atc acc aag ctg gaa ccg cat ccg 211Phe Glu Gly Thr Pro Asn Val Lys Ile Thr Lys Leu Glu Pro His Pro

25 30 35ggc cgg acc tca att atc gtg act gtt cca ggc agc gat cca gat gct 259Gly Arg Thr Ser Ile Ile Val Thr Val Pro Gly Ser Asp Pro Asp Ala

40 45 50gag cct tta aca ctg ctt gga cat act gat gtt gtg cct gtt gat ctg 307Glu Pro Leu Thr Leu Leu Gly His Thr Asp Val Val Pro Val Asp Leu

55 60 65cct aaa tgg act aaa gat cca ttc ggt gcg gag att tcg gat gga cag 355Pro Lys Trp Thr Lys Asp Pro Phe Gly Ala Glu Ile Ser Asp Gly Gln 70 75 80 85att tgg ggt aga ggg tcc gtc gat atg ctc ttt att acc gca acc caa 403Ile Trp Gly Arg Gly Ser Val Asp Met Leu Phe Ile Thr Ala Thr Gln

90 95 100gcg gcc gtc acc cgt caa gta gcc cgt gaa ggc ggc ctg cgt ggc acg 451Ala Ala Val Thr Arg Gln Val Ala Arg Glu Gly Gly Leu Arg Gly Thr

105 110 115ctg aca ttc gtt ggc gtt gct gat gag gaa gcc cgc ggc gga ctc gga 499Leu Thr Phe Val Gly Val Ala Asp Glu Glu Ala Arg Gly Gly Leu Gly

120 125130gcg aag tgg ctt tcc gaa gaa cac caa aac ctc ttc agc tgg aaa aac 547Ala Lys Trp Leu Ser Glu Glu His Gln Asn Leu Phe Ser Trp Lys Asn

135 140 145tgc ctc tcc gaa tcc ggt gga tcg cac ctt cca gtc cac gac ggc agc 595Cys Leu Ser Glu Ser Gly Gly Ser His Leu Pro Val His Asp Gly Ser150 155 160 165gac gca gta gta att aac gtt gga gaa aaa ggt gca gct caa cgt cgt 643Asp Ala Val Val Ile Asn Val Gly Glu Lys Gly Ala Ala Gln Arg Arg

170 175 180att cac gtc aat ggc gat gct ggt cat ggt tcc att cct ttc gac cgt 691Ile His Val Asn Gly Asp Ala Gly His Gly Ser Ile Pro Phe Asp Arg

185 190 195gac agc gct att gtc aag atc ggt gaa gtc gcc cgc cga atc gct gcc 739Asp Ser Ala Ile Val Lys Ile Gly Glu Val Ala Arg Arg Ile Ala Ala

200 205 210gcc gat ctg aag gta gcc aag gac gat atc tgg caa ggc ttc gtc caa 787Ala Asp Leu Lys Val Ala Lys Asp Asp Ile Trp Gln Gly Phe Val Gln

215 220 225gcg cac cgt ttc gac cca gaa acg gag cag gcg ctt ctt agc ggg acc 835Ala His Arg Phe Asp Pro Glu Thr Glu Gln Ala Leu Leu Ser Gly Thr230 235 240 245tcc cct gag gcc tac gca gag ttc ggc gga ctc tcc cgc ttc gcc cac 883Ser Pro Glu Ala Tyr Ala Glu Phe Gly Gly Leu Ser Arg Phe Ala His

250 255 260gcg gtg tct cat ctc acg atc gcc caa act gtg gtt cgt gca ggt caa 931Ala Val Ser His Leu Thr Ile Ala Gln Thr Val Val Arg Ala Gly Gln

265 270 275gcc atc aat gta ttg cca tcg cat gcg tac ttg gaa ctg gat atc cgt 979Ala Ile Asn Val Leu Pro SerHis Ala Tyr Leu Glu Leu Asp Ile Arg

280 285 290acc ctt cca ggc caa acc aat gac tat gtt gat gac acc ctg cgt gct 1027Thr Leu Pro Gly Gln Thr Asn Asp Tyr Val Asp Asp Thr Leu Arg Ala

295 300 305gct ctg ggc gat ctt gcc gat gaa gta gaa atc gaa cac ctc atc tct 1075Ala Leu Gly Asp Leu Ala Asp Glu Val Glu Ile Glu His Leu Ile Ser310 315 320 325gaa gaa gca acg gtg agc cca act gat tcc agg ttg tat aac acc ttg 1123Glu Glu Ala Thr Val Ser Pro Thr Asp Ser Arg Leu Tyr Asn Thr Leu

330 335 340gaa aaa gtt ctt ggt gat ttc ttc ccc gat gcg cct gtg gtc cca att 1171Glu Lys Val Leu Gly Asp Phe Phe Pro Asp Ala Pro Val Val Pro Ile

345 350 355att tcc tct ggt ggc tct gac ctg cgc ttt ggt cgt cga cta ggc ggt 1219Ile Ser Ser Gly Gly Ser Asp Leu Arg Phe Gly Arg Arg Leu Gly Gly

360 365 370gtt ggt tat ggt ttt gca gtt cat gca cgt gaa cga act ttg gcg gaa 1267Val Gly Tyr Gly Phe Ala Val His Ala Arg Glu Arg Thr Leu Ala Glu

375 380 385gca atg ggg caa ctt cac tcc cat gac gag gcg ctg tac ctg gaa gat 1315Ala Met Gly Gln Leu His Ser His Asp Glu Ala Leu Tyr Leu Glu Asp390 395 400 405ctt gaa ctg act gtt cgg ggt tat gac tcc gtc gtg cgt gaa ttc cta 1363Leu Glu Leu Thr Val Arg Gly Tyr Asp Ser Val Val Arg Glu Phe Leu

410415420 ggc taaaaacatg aagcaggagt ctt 1389Gly<210>372<211>422<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>372Val Asn Asp Leu Thr Pro Asp Ser Gly Gln Glu Ile Arg Asn Ala Glu 151015 Ser Leu Glu ArgPhe Phe Glu Gly Thr Pro Asn Val Lys Ile Thr Lys

20 25 30Leu Glu Pro His Pro Gly Arg Thr Ser Ile Ile Val Thr Val Pro Gly

35 40 45Ser Asp Pro Asp Ala Glu Pro Leu Thr Leu Leu Gly His Thr Asp Val

50 55 60Val Pro Val Asp Leu Pro Lys Trp Thr Lys Asp Pro Phe Gly Ala Glu 65 70 75 80Ile Ser Asp Gly Gln Ile Trp Gly Arg Gly Ser Val Asp Met Leu Phe

85 90 95Ile Thr Ala Thr Gln Ala Ala Val Thr Arg Gln Val Ala Arg Glu Gly

100 105 110Gly Leu Arg Gly Thr Leu Thr Phe Val Gly Val Ala Asp Glu Glu Ala

115 120 125Arg Gly Gly Leu Gly Ala Lys Trp Leu Ser Glu Glu His Gln Asn Leu

130 135 140Phe Ser Trp Lys Asn Cys Leu Ser Glu Ser Gly Gly Ser His Leu Pro145 150 155 160Val His Asp Gly Ser Asp Ala Val Val Ile Asn Val Gly Glu Lys Gly

165 170 175Ala Ala Gln Arg Arg Ile His Val Asn Gly Asp Ala Gly His Gly Ser

180 185 190Ile Pro Phe Asp Arg Asp Ser Ala Ile Val Lys Ile Gly Glu Val Ala

195 200 205Arg Arg Ile Ala Ala Ala Asp Leu Lys Val Ala Lys Asp Asp Ile Trp

210 215 220Gln Gly Phe Val Gln Ala His Arg Phe Asp Pro Glu Thr Glu Gln Ala225 230 235 240Leu Leu Ser Gly Thr Ser Pro Glu Ala Tyr Ala Glu Phe Gly Gly Leu

245 250 255Ser Arg Phe Ala His Ala Val Ser His Leu Thr Ile Ala Gln Thr Val

260 265 270Val Arg Ala Gly Gln Ala Ile Asn Val Leu Pro Ser His Ala Tyr Leu

275 280 285Glu Leu Asp Ile Arg Thr Leu Pro Gly Gln Thr Asn Asp Tyr Val Asp

290 295 300Asp Thr Leu Arg Ala Ala Leu Gly Asp Leu Ala Asp Glu Val Glu Ile305 310 315 320Glu His Leu Ile Ser Glu Glu Ala Thr Val Ser Pro Thr Asp Ser Arg

325 330 335Leu Tyr Asn Thr Leu Glu Lys Val Leu Gly Asp Phe Phe Pro Asp Ala

340 345 350Pro Val Val Pro Ile Ile Ser Ser Gly Gly Ser Asp Leu Arg Phe Gly

355 360 365Arg Arg Leu Gly Gly Val Gly Tyr Gly Phe Ala Val His Ala Arg Glu

370 375 380Arg Thr Leu Ala Glu Ala Met Gly Gln Leu His Ser His Asp Glu Ala385 390 395 400Leu Tyr Leu Glu Asp Leu Glu Leu Thr Val Arg Gly Tyr Asp Ser Val

405 410 415Val Arg Glu Phe Leu Gly

420<210>373<211>525<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (502)<223>RXS02937<400>373gctaccgcga agaactgtac tagttcttcc atcagcaccc gcagttgtct ttgcaagagt 60tcgaaacatc caacgcattg gtgacaccgg tgttgtcgcg gtg atc agc aat ggg 115

Val Ile Ser Asn Gly

1 5gaa ggt ccg gtt gtt gcg ctt cgt ggc gac att gat gcg ttg ccc atg 163Glu Gly Pro Val Val Ala Leu Arg Gly Asp Ile Asp Ala Leu Pro Met

10 15 20gcg gag cga tcc ggc aaa gaa tac gca gca acc gga gtg aca cag gtg 211Ala Glu Arg Ser Gly Lys Glu Tyr Ala Ala Thr Gly Val Thr Gln Val

25 30 35gat aac acc acc ggt caa gaa act ccg gtg gcg cat acc tgt ggc cac 259Asp Asn Thr Thr Gly Gln Glu Thr Pro Val Ala His Thr Cys Gly His

40 45 50gat gtg cat att tca tca ctg ttg ggt gcg gtg cag gcg ttc aat tct 307Asp Val His Ile Ser Ser Leu Leu Gly Ala Val Gln Ala Phe Asn Ser

55 60 65cat cgg gaa ttg tgg aac gga acg ttg atg gcc gtt ttc cag cca gcg 355His Arg Glu Leu Trp Asn Gly Thr Leu Met Ala Val Phe Gln Pro Ala 70 75 80 85gaa gag acg gca gct ggt gcg agg atg atg gcg gat cag gac aac gcg 403Glu Glu Thr Ala Ala Gly Ala Arg Met Met Ala Asp Gln Asp Asn Ala

90 95 100ccg gga aat cac tct cca gcg ttc gcg cca gat atg cag cca act ctt 451Pro Gly Asn His Ser Pro Ala Phe Ala Pro Asp Met Gln Pro Thr Leu

105 110 115gat cgt ggt gtg gaa gcg ctg gtt gta gct gct tct gcg tgg cta gta 499Asp Arg Gly Val Glu Ala Leu Val Val Ala Ala Ser Ala Trp Leu Val

120125130 aaa taattggcta atgaatcctt ttc 525Lys<210>374<211>134<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>374Val Ile Ser Asn Gly Glu Gly Pro Val Val Ala Leu Arg Gly Asp Ile 151015 Asp Ala Leu Pro Met Ala Glu Arg Ser Gly Lys Glu Tyr Ala Ala Thr

20 25 30Gly Val Thr Gln Val Asp Asn Thr Thr Gly Gln Glu Thr Pro Val Ala

35 40 45His Thr Cys Gly His Asp Val His Ile Ser Ser Leu Leu Gly Ala Val

50 55 60Gln Ala Phe Asn Ser His Arg Glu Leu Trp Asn Gly Thr Leu Met Ala 65 70 75 80Val Phe Gln Pro Ala Glu Glu Thr Ala Ala Gly Ala Arg Met Met Ala

85 90 95Asp Gln Asp Asn Ala Pro Gly Asn His Ser Pro Ala Phe Ala Pro Asp

100 105 110Met Gln Pro Thr Leu Asp Arg Gly Val Glu Ala Leu Val Val Ala Ala

115 120 125Ser Ala Trp Leu Val Lys

130<210>375<211>966<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (943)<223>RXA02194<400>375gaaatctccc agctcattta ttggacccag gtcatcatgg ttgctcgcgg cctgaagcca 60gaagatatct acaagaacct gtaggagttt taaagcaatc atg ttg aaa atc gct 115

Met Leu Lys Ile Ala

1 5gtc cca aac aaa ggc tcg ctg tcc gag cgc gcc atg gaa atc ctc gcc 163Val Pro Asn Lys Gly Ser Leu Ser Glu Arg Ala Met Glu Ile Leu Ala

10 15 20gaa gca ggc tac gca ggc cgt gga gat tcc aaa tcc ctc aac gtt ttt 211Glu Ala Gly Tyr Ala Gly Arg Gly Asp Ser Lys Ser Leu Asn Val Phe

2530 35gat gaa gca aac aac gtt gaa ttc ttc ttc ctt cgc cct aaa gat atc 259Asp Glu Ala Asn Asn Val Glu Phe Phe Phe Leu Arg Pro Lys Asp Ile

40 45 50gcc atc tac gtt gct ggt ggc cag ctc gat ttg ggt atc acc ggc cgc 307Ala Ile Tyr Val Ala Gly Gly Gln Leu Asp Leu Gly Ile Thr Gly Arg

55 60 65gac ctt gct cgc gat tcc cag gct gat gtc cac gaa gtt ctt tcc ctc 355Asp Leu Ala Arg Asp Ser Gln Ala Asp Val His Glu Val Leu Ser Leu 70 75 80 85ggc ttc ggt tcc tcc act ttc cgt tac gca gca cca gct gat gaa gag 403Gly Phe Gly Ser Ser Thr Phe Arg Tyr Ala Ala Pro Ala Asp Glu Glu

90 95 100tgg agc atc gaa aag ctc gac ggc aag cgc atc gct acc tct tac ccc 451Trp Ser Ile Glu Lys Leu Asp Gly Lys Arg Ile Ala Thr Ser Tyr Pro

105 110 115aac ctt gtt cgc gat gac ctc gca gca cgt ggg ctt tcc gct gag gtg 499Asn Leu Val Arg Asp Asp Leu Ala Ala Arg Gly Leu Ser Ala Glu Val

120 125 130ctc cgc ctc gac ggt gca gta gag gta tcc atc aag ctt ggt gtc gca 547Leu Arg Leu Asp Gly Ala Val Glu Val Ser Ile Lys Leu Gly Val Ala

135 140 145gat gcc atc gcc gat gtt gta tcc acc ggc cgc acg ctg cgt cag caa 595Asp Ala Ile Ala Asp Val Val Ser Thr Gly Arg Thr Leu Arg Gln Gln150 155 160 165ggt ctt gca cct ttc ggc gag gtt ctg tgc acc tct gag gct gtc att 643Gly Leu Ala Pro Phe Gly Glu Val Leu Cys Thr Ser Glu Ala Val Ile

170 175 180gtt ggc cgc aag gat gaa aag gtc acc cca gag cag cag atc ctg ctt 691Val Gly Arg Lys Asp Glu Lys Val Thr Pro Glu Gln Gln Ile Leu Leu

185 190 195cgc cgc atc cag gga att ttg cac gcg cag aac ttc ctc atg ctg gat 739Arg Arg Ile Gln Gly Ile Leu His Ala Gln Asn Phe Leu Met Leu Asp

200 205 210tac aac gtc gac cgc gac aac ctg gac gct gcc act gca gta acc cca 787Tyr Asn Val Asp Arg Asp Asn Leu Asp Ala Ala Thr Ala Val Thr Pro

215 220 225ggc tta tcc ggc cca acg gta tcc cca ctg gca cgc gac aac tgg gtt 835Gly Leu Ser Gly Pro Thr Val Ser Pro Leu Ala Arg Asp Asn Trp Val230 235 240 245gct gta cgc gcc atg gtg cca cgc agg tca gct aac gcc atc atg gat 883Ala Val Arg Ala Met Val Pro Arg Arg Ser Ala Asn Ala Ile Met Asp

250 255 260aag ctt gct gga ctc ggc gct gaa gcc atc ctg gct tct gaa atc cgc 931Lys Leu Ala Gly Leu Gly Ala Glu Ala Ile Leu Ala Ser Glu Ile Arg

265 270 275atc gcc cgc atc tagttttaac tacccccgaa aat 966Ile Ala Arg Ile

280<210>376<211>281<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>376Met Leu Lys Ile Ala Val Pro Asn Lys Gly Ser Leu Ser Glu Arg Ala 151015 Met Glu Ile Leu Ala Glu Ala Gly Tyr Ala Gly Arg Gly Asp Ser Lys

20 25 30Ser Leu Asn Val Phe Asp Glu Ala Asn Asn Val Glu Phe Phe Phe Leu

35 40 45Arg Pro Lys Asp Ile Ala Ile Tyr Val Ala Gly Gly Gln Leu Asp Leu

50 55 60Gly Ile Thr Gly Arg Asp Leu Ala Arg Asp Ser Gln Ala Asp Val His 6570 75 80Glu Val Leu Ser Leu Gly Phe Gly Ser Ser Thr Phe Arg Tyr Ala Ala

85 90 95Pro Ala Asp Glu Glu Trp Ser Ile Glu Lys Leu Asp Gly Lys Arg Ile

100 105 110Ala Thr Ser Tyr Pro Asn Leu Val Arg Asp Asp Leu Ala Ala Arg Gly

115 120 125Leu Ser Ala Glu Val Leu Arg Leu Asp Gly Ala Val Glu Val Ser Ile

130 135 140Lys Leu Gly Val Ala Asp Ala Ile Ala Asp Val Val Ser Thr Gly Arg145 150 155 160Thr Leu Arg Gln Gln Gly Leu Ala Pro Phe Gly Glu Val Leu Cys Thr

165 170 175Ser Glu Ala Val Ile Val Gly Arg Lys Asp Glu Lys Val Thr Pro Glu

180 185 190Gln Gln Ile Leu Leu Arg Arg Ile Gln Gly Ile Leu His Ala Gln Asn

195 200 205Phe Leu Met Leu Asp Tyr Asn Val Asp Arg Asp Asn Leu Asp Ala Ala

210 215 220Thr Ala Val Thr Pro Gly Leu Ser Gly Pro Thr Val Ser Pro Leu Ala225 230 235 240Arg Asp Asn Trp Val Ala Val Arg Ala Met Val Pro Arg Arg Ser Ala

245 250 255Asn Ala Ile Met Asp Lys Leu Ala Gly Leu Gly Ala Glu Ala Ile Leu

260 265 270Ala Ser Glu Ile Arg Ile Ala Arg Ile

275280<210>377<211>393<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (370)<223>RXA02195<400>377tcgagccggc aggtgtcgca aaataaaacc aggtggggga gtgaaattat tcgactaata 60tcctccccca aacacacatt gataactgtt gtgtggaaga atg tac cga gtg aag 115

Met Tyr Arg Val Lys

1 5aca ttt gac tcg ctg tac gaa gaa ctt ctt aac cgt gct cag acc cgc 163Thr Phe Asp Ser Leu Tyr Glu Glu Leu Leu Asn Arg Ala Gln Thr Arg

10 15 20cct gaa ggg tct gga acc gtg gcc gcc ttg gat aaa ggc atc cat cat 211Pro Glu Gly Ser Gly Thr Val Ala Ala Leu Asp Lys Gly Ile His His

25 30 35cta ggt aag aag gtc atc gaa gaa gcc gga gag gtc tgg att gca gcc 259Leu Gly Lys Lys Val Ile Glu Glu Ala Gly Glu Val Trp Ile Ala Ala

40 45 50gag tat gag acc gat gaa gag cta gcc gga gaa atc tcc cag ctc att 307Glu Tyr Glu Thr Asp Glu Glu Leu Ala Gly Glu Ile Ser Gln Leu Ile

55 60 65tat tgg acc cag gtc atc atg gtt gct cgc ggc ctg aag cca gaa gat 355Tyr Trp Thr Gln Val Ile Met Val Ala Arg Gly Leu Lys Pro Glu Asp 70 75 80 85atc tac aag aac ctg taggagtttt aaagcaatca tgt 393Ile Tyr Lys Asn Leu

90<210>378<211>90<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>378Met Tyr Arg Val Lys Thr Phe Asp Ser Leu Tyr Glu Glu Leu Leu Asn 151015 Arg Ala Gln Thr Arg Pro Glu Gly Ser Gly Thr Val Ala Ala Leu Asp

20 25 30Lys Gly Ile His His Leu Gly Lys Lys Val Ile Glu Glu Ala Gly Glu

3540 45Val Trp Ile Ala Ala Glu Tyr Glu Thr Asp Glu Glu Leu Ala Gly Glu

50 55 60Ile Ser Gln Leu Ile Tyr Trp Thr Gln Val Ile Met Val Ala Arg Gly 65 70 75 80Leu Lys Pro Glu Asp Ile Tyr Lys Asn Leu

8590<210>379<211>477<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (454)<223>RXA01097<400>379gcgccaacgc agtgcttgcc gcgaccattt tccacttccg cgaagtaacc atcgccgaag 60taaagggagc cattaaagat gcaggatttg aggtgcggaa atg agt gac aat cca 115

Met Ser Asp Asn Pro

1 5caa gag tat gag ctg gat tgg gac gtc gaa aag cga tta aag ctt aac 163Gln Glu Tyr Glu Leu Asp Trp Asp Val Glu Lys Arg Leu Lys Leu Asn

10 15 20gac gcc ggc ctg gtg ccg gca atc gtc cag gcc gac ggg acc aac gag 211Asp Ala Gly Leu Val Pro Ala Ile Val Gln Ala Asp Gly Thr Asn Glu

25 30 35gtc ctc atg atg gcc tgg atg gat acc cac gcg cta gcc tat act ttg 259Val Leu Met Met Ala Trp Met Asp Thr His Ala Leu Ala Tyr Thr Leu

40 45 50gcg acc cgc cgt gga acc tat ttt tct agg tcc cgc aac gag tac tgg 307Ala Thr Arg Arg Gly Thr Tyr Phe Ser Arg Ser Arg Asn Glu Tyr Trp

55 60 65atc aag ggc ctg acc tct gga aac gtc caa gaa gtc acc gga ctt gcc 355Ile Lys Gly Leu Thr Ser Gly Asn Val Gln Glu Val Thr Gly Leu Ala 70 75 80 85ctc gac tgc gac ggc gac acc gtc ctt ctg acc gtg aaa caa acc ggc 403Leu Asp Cys Asp Gly Asp Thr Val Leu Leu Thr Val Lys Gln Thr Gly

90 95 100ggt gcg tgc cac act ggt gcc cac aca tgt ttc gac aat gac gtt ttg 451Gly Ala Cys His Thr Gly Ala His Thr Cys Phe Asp Asn Asp Val Leu

105110115 ctg taaaagcaac aacgattaag gaa 477Leu<210>380<211>118<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>380Met Ser Asp Asn Pro Gln Glu Tyr Glu Leu Asp Trp Asp Val Glu Lys 151015 Arg Leu Lys Leu Asn Asp Ala Gly Leu Val Pro Ala Ile Val Gln Ala

20 25 30Asp Gly Thr Asn Glu Val Leu Met Met Ala Trp Met Asp Thr His Ala

35 40 45Leu Ala Tyr Thr Leu Ala Thr Arg Arg Gly Thr Tyr Phe Ser Arg Ser

50 55 60Arg Asn Glu Tyr Trp Ile Lys Gly Leu Thr Ser Gly Asn Val Gln Glu 65 70 75 80Val Thr Gly Leu Ala Leu Asp Cys Asp Gly Asp Thr Val Leu Leu Thr

85 90 95Val Lys Gln Thr Gly Gly Ala Cys His Thr Gly Ala His Thr Cys Phe

100 105 110Asp Asn Asp Val Leu Leu

115<210>381<211>861<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (838)<223>RXA01100<400>381gctgtgggct actcaattcc acccagaaaa atcaggtgac gcaggcgcac agctactgcg 60aaactggatc aactacatct aacagatagg atcaatattc atg acc ttc act att 115

Met Thr Phe Thr Ile

1 5ctt cct gca gtc gat gta gtt aac gga caa gca gtt cgc cta gat cag 163Leu Pro Ala Val Asp Val Val Asn Gly Gln Ala Val Arg Leu Asp Gln

10 15 20ggc gag gcc ggc act gaa aag tct tat ggc acc cct ttg gaa tcc gca 211Gly Glu Ala Gly Thr Glu Lys Ser Tyr Gly Thr Pro Leu Glu Ser Ala

25 30 35ctg aag tgg cag gag cag ggt gca aag tgg ttg cac ttt gtg gac ctg 259Leu Lys Trp Gln Glu Gln Gly Ala Lys Trp Leu His Phe Val Asp Leu

40 45 50gac gca gcg ttc aac cgt ggt tcc aac cat gag atg atg gcg gaa att 307Asp Ala Ala Phe Asn Arg Gly Ser Asn His Glu Met Met Ala Glu Ile

55 60 65gtc ggc aag ctc gat gtt gat gtg gag ctc act ggc ggt atc cgt gat 355Val Gly Lys Leu Asp Val Asp Val Glu Leu Thr Gly Gly Ile Arg Asp 70 75 80 85gat gag tct ctg gag cgc gcg ctg gca acc ggt gca cgt cgt gta aac 403Asp Glu Ser Leu Glu Arg Ala Leu Ala Thr Gly Ala Arg Arg Val Asn

90 95 100att ggt acc gct gct ctg gag aag cca gag tgg att gct tct gcg att 451Ile Gly Thr Ala Ala Leu Glu Lys Pro Glu Trp Ile Ala Ser Ala Ile

105 110 115caa cgc tat ggc gag aag att gct gtc gat atc gct gtg cgt ttg gaa 499Gln Arg Tyr Gly Glu Lys Ile Ala Val Asp Ile Ala Val Arg Leu Glu

120 125 130gat ggt gaa tgg cgc acc cgt gga aac ggt tgg gtc tcc gat ggt ggc 547Asp Gly Glu Trp Arg Thr Arg Gly Asn Gly Trp Val Ser Asp Gly Gly

135 140 145gat ctg tgg gaa gtt ctc gag cgt ttg gat tcc caa ggt tgtgca cgt 595Asp Leu Trp Glu Val Leu Glu Arg Leu Asp Ser Gln Gly Cys Ala Arg150 155 160 165ttc gtg gtt acc gat gtg tcc aag gac ggc acc ttg agt ggt cca aat 643Phe Val Val Thr Asp Val Ser Lys Asp Gly Thr Leu Ser Gly Pro Asn

170 175 180gtt gag ctg ctg cgt gag gtt gct gca gct aca gac gca cct atc gtg 691Val Glu Leu Leu Arg Glu Val Ala Ala Ala Thr Asp Ala Pro Ile Val

185 190 195gca tct ggt gga att tct gtt ttg gaa gat gtt ttg gaa cta gcc aag 739Ala Ser Gly Gly Ile Ser Val Leu Glu Asp Val Leu Glu Leu Ala Lys

200 205 210tac cag gat gag ggc att gat tcc gtc atc att ggc aag gca ctt tat 787Tyr Gln Asp Glu Gly Ile Asp Ser Val Ile Ile Gly Lys Ala Leu Tyr

215220225 gag cac aag ttc acc ctc gaa gag gct ttg gct gca gta gaa aag ctc 835Glu His Lys Phe Thr Leu Glu Glu Ala Leu Ala Ala Val Glu Lys Leu 230235240245 ggt taatacatgg atgctcgtgg gat 861Gly<210>382<211>246<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>382Met Thr Phe Thr Ile Leu Pro Ala Val Asp Val Val Asn Gly Gln Ala 151015 Val Arg Leu Asp Gln Gly Glu Ala Gly Thr Glu Lys Ser Tyr Gly Thr

20 25 30Pro Leu Glu Ser Ala Leu Lys Trp Gln Glu Gln Gly Ala Lys Trp Leu

35 40 45His Phe Val Asp Leu Asp Ala Ala Phe Asn Arg Gly Ser Asn His Glu

50 55 60Met Met Ala Glu Ile Val Gly Lys Leu Asp Val Asp Val Glu Leu Thr 65 70 75 80Gly Gly Ile Arg Asp Asp Glu Ser Leu Glu Arg Ala Leu Ala Thr Gly

85 90 95Ala Arg Arg Val Asn Ile Gly Thr Ala Ala Leu Glu Lys Pro Glu Trp

100 105 110Ile Ala Ser Ala Ile Gln Arg Tyr Gly Glu Lys Ile Ala Val Asp Ile

115 120 125Ala Val Arg Leu Glu Asp Gly Glu Trp Arg Thr Arg Gly Asn Gly Trp

130 135 140Val Ser Asp Gly Gly Asp Leu Trp Glu Val Leu Glu Arg Leu Asp Ser145 150 155 160Gln Gly Cys Ala Arg Phe Val Val Thr Asp Val Ser Lys Asp Gly Thr

165 170 175Leu Ser Gly Pro Asn Val Glu Leu Leu Arg Glu Val Ala Ala Ala Thr

180 185 190Asp Ala Pro Ile Val Ala Ser Gly Gly Ile Ser Val Leu Glu Asp Val

195 200 205Leu Glu Leu Ala Lys Tyr Gln Asp Glu Gly Ile Asp Ser Val Ile Ile

210 215 220Gly Lys Ala Leu Tyr Glu His Lys Phe Thr Leu Glu Glu Ala Leu Ala225 230 235 240Ala Val Glu Lys Leu Gly

245<210>383<211>756<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (733)<223>RXA01101<400>383atcgcagcta ggccagtgtg gtggatataa aacccttttg gggagaaaga aactcgactg 60cggttcttga tcctgaaagc acgtgacata aactatcggc atg acc aaa act gtc 115

Met Thr Lys Thr Val

1 5gcc ctt ctc gac tac gga tct gga aac ctt cgt tct gct caa cgc gca 163Ala Leu Leu Asp Tyr Gly Ser Gly Asn LeuArg Ser Ala Gln Arg Ala

10 15 20cta gag cgt gcc ggt gca gaa gtt atc gtg agc tcc gat cca gaa gtt 211Leu Glu Arg Ala Gly Ala Glu Val Ile Val Ser Ser Asp Pro Glu Val

25 30 35tgc acc aac gct gat ggc ctc cta gtt cct gga gtg ggc gca ttt gat 259Cys Thr Asn Ala Asp Gly Leu Leu Val Pro Gly Val Gly Ala Phe Asp

40 45 50gcc tgc atg aag ggt ttg aaa aac gtc ttc gga cat cgc att atc gga 307Ala Cys Met Lys Gly Leu Lys Asn Val Phe Gly His Arg Ile Ile Gly

55 60 65cag cgt ctt gct ggt gga cgt cca gtg atg ggt att tgt gtg ggc atg 355Gln Arg Leu Ala Gly Gly Arg Pro Val Met Gly Ile Cys Val Gly Met 70 75 80 85cag atc ctg ttc gat gaa ggc gat gag cac ggc att aag tca gct ggt 403Gln Ile Leu Phe Asp Glu Gly Asp Glu His Gly Ile Lys Ser Ala Gly

90 95 100tgc ggc gag tgg cct ggc aaa gtg gaa cgc ctc caa gcg gag atc ctg 451Cys Gly Glu Trp Pro Gly Lys Val Glu Arg Leu Gln Ala Glu Ile Leu

105 110 115cct cac atg ggg tgg aac aca ctt gaa atg cct acc aac tca cca atg 499Pro His Met Gly Trp Asn Thr Leu Glu Met Pro Thr Asn Ser Pro Met

120 125 130ttt gag gga att tca cct gat gag cgt ttc tac ttc gtg cac tcc tat 547Phe Glu Gly Ile Ser Pro Asp Glu Arg Phe Tyr Phe Val His Ser Tyr

135 140 145ggt gtg cgc aag tgg acg ttg gaa acc gac gat ctg acc acg cct cca 595Gly Val Arg Lys Trp Thr Leu Glu Thr Asp Asp Leu Thr Thr Pro Pro150 155 160 165gag gtt gtg tgg gcg aag cac gaa aat gat cgt ttt gtg gca gct gtg 643Glu Val Val Trp Ala Lys His Glu Asn Asp Arg Phe Val Ala Ala Val

170 175 180gaa aac ggc acg ctg tgg gct act caa ttc cac cca gaa aaa tca ggt 691Glu Asn Gly Thr Leu Trp Ala Thr Gln Phe His Pro Glu Lys Ser Gly

185 190 195gac gca ggc gca cag cta ctg cga aac tgg atc aac tac atc 733Asp Ala Gly Ala Gln Leu Leu Arg Asn Trp Ile Asn Tyr Ile

200205210 taacagatag gatcaatatt cat 756<210>384<211>211<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>384Met Thr Lys Thr Val Ala Leu Leu Asp Tyr Gly Ser Gly Asn Leu Arg 151015 Ser Ala Gln Arg Ala Leu Glu Arg Ala Gly Ala Glu Val Ile Val Ser

20 25 30Ser Asp Pro Glu Val Cys Thr Asn Ala Asp Gly Leu Leu Val Pro Gly

35 40 45Val Gly Ala Phe Asp Ala Cys Met Lys Gly Leu Lys Asn Val Phe Gly

50 55 60His Arg Ile Ile Gly Gln Arg Leu Ala Gly Gly Arg Pro Val Met Gly 65 70 75 80Ile Cys Val Gly Met Gln Ile Leu Phe Asp Glu Gly Asp Glu His Gly

85 90 95Ile Lys Ser Ala Gly Cys Gly Glu Trp Pro Gly Lys Val Glu Arg Leu

100 105 110Gln Ala Glu Ile Leu Pro His Met Gly Trp Asn Thr Leu Glu Met Pro

115 120 125Thr Asn Ser Pro Met Phe Glu Gly Ile Ser Pro Asp Glu Arg Phe Tyr

130 135 140Phe Val His Ser Tyr Gly Val Arg Lys Trp Thr Leu Glu Thr Asp Asp145 150 155 160Leu Thr Thr Pro Pro Glu Val Val Trp Ala Lys His Glu Asn Asp Arg

165 170 175Phe Val Ala Ala Val Glu Asn Gly Thr Leu Trp Ala Thr Gln Phe His

180 185 190Pro Glu Lys Ser Gly Asp Ala Gly Ala Gln Leu Leu Arg Asn Trp Ile

195 200 205Asn Tyr Ile

210<210>385<211>723<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (700)<223>RXN01657<400>385cctccgtcat tgccgacgta tcccgcggcc tgggtgaagc catggtgggc atcaacgtat 60ccgacgttcc agcaccacac cgactcgccg agcgcggctg gtg atc gtt gga gtt 115

Val Ile Val Gly Val

1 5tta gct ctc cag ggc ggg gtg gaa gaa cac ctc acc gcc ttg gaa gct 163Leu Ala Leu Gln Gly Gly Val Glu Glu His Leu Thr Ala Leu Glu Ala

10 15 20ctc gga gcg acg acc cga aaa gta cgt gtg cca aag gac ctt gat ggt 211Leu Gly Ala Thr Thr Arg Lys Val Arg Val Pro Lys Asp Leu Asp Gly

25 30 35ctc gaa ggc atc gtc atc ccc ggc ggg gaa tcc acc gtg ttg gac aaa 259Leu Glu Gly Ile Val Ile Pro Gly Gly Glu Ser Thr Val Leu Asp Lys

40 45 50ctg gct cgg aca ttc gac gtg gta gaa cct cta gcg aat ctc att cgc 307Leu Ala Arg Thr Phe Asp Val Val Glu Pro Leu Ala Asn Leu Ile Arg

55 60 65gac ggc cta ccc gtt ttc gct acc tgc gct ggc ctg atc tat ctg gcg 355Asp Gly Leu Pro Val Phe Ala Thr Cys Ala Gly Leu Ile Tyr Leu Ala 70 75 80 85aaa cac ctc gac aac cca gca agg gga caa caa acc ttg gcg gta gtg 403Lys His Leu Asp Asn Pro Ala Arg Gly Gln Gln Thr Leu Ala Val Val

90 95 100gac gtg gtg gtg cgt cga aac gca ttt ggc gcc caa cgc gaa tcc ttc 451Asp Val Val Val Arg Arg Asn Ala Phe Gly Ala Gln Arg Glu Ser Phe

105 110 115gac acc acc gtg gat gtt tcc ttc gac ggt gca aca ttc ccc gga gtg 499Asp Thr Thr Val Asp Val Ser Phe Asp Gly Ala Thr Phe Pro Gly Val

120 125 130cag gcc tcg ttt atc cga gct ccc atc gtc act gct ttt ggt cct acg 547Gln Ala Ser Phe Ile Arg Ala Pro Ile Val Thr Ala Phe Gly Pro Thr

135 140 145gta gaa gcg atc gct gct ctc aac ggt ggg gag gtg gtt ggt gta cgc 595Val Glu Ala Ile Ala Ala Leu Asn Gly Gly Glu Val Val Gly Val Arg150 155 160 165caa ggc aac atc atc gcg ctg tct ttc cat ccc gaa gaa acc ggc gat 643Gln Gly Asn Ile Ile Ala Leu Ser Phe His Pro Glu Glu Thr Gly Asp

170 175 180tac cgc atc cac caa gcc tgg ctg gac ctg gtg aga aaa cac gct gaa 691Tyr Arg Ile His Gln Ala Trp Leu Asp Leu Val Arg Lys His Ala Glu

185 190 195ctg gcg att tgatgttttc ggtagcgctc tgt 723Leu Ala Ile

200<210>386<211>200<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>386Val Ile Val Gly Val Leu Ala Leu Gln Gly Gly Val Glu Glu His Leu 151015 Thr Ala Leu Glu Ala Leu GlyAla Thr Thr Arg Lys Val Arg Val Pro

20 25 30Lys Asp Leu Asp Gly Leu Glu Gly Ile Val Ile Pro Gly Gly Glu Ser

35 40 45Thr Val Leu Asp Lys Leu Ala Arg Thr Phe Asp Val Val Glu Pro Leu

50 55 60Ala Asn Leu Ile Arg Asp Gly Leu Pro Val Phe Ala Thr Cys Ala Gly 65 70 75 80Leu Ile Tyr Leu Ala Lys His Leu Asp Asn Pro Ala Arg Gly Gln Gln

85 90 95Thr Leu Ala Val Val Asp Val Val Val Arg Arg Asn Ala Phe Gly Ala

100 105 110Gln Arg Glu Ser Phe Asp Thr Thr Val Asp Val Ser Phe Asp Gly Ala

115 120 125Thr Phe Pro Gly Val Gln Ala Ser Phe Ile Arg Ala Pro Ile Val Thr

130 135 140Ala Phe Gly Pro Thr Val Glu Ala Ile Ala Ala Leu Asn Gly Gly Glu145 150 155 160Val Val Gly Val Arg Gln Gly Asn Ile Ile Ala Leu Ser Phe His Pro

165 170 175Glu Glu Thr Gly Asp Tyr Arg Ile His Gln Ala Trp Leu Asp Leu Val

180 185 190Arg Lys His Ala Glu Leu Ala Ile

195200<210>387<211>601<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (601)<223>FRXA01657<400>387cctccgtcat tgccgacgta tcccgcggcc tgggtgaagc catggtgggc atcaacgtat 60ccgacgttcc agcaccacac cgactcgccg agcgcggctg gtg atc gtt gga gtt 115

Val Ile Val Gly Val

1 5tta gct ctc cag ggc ggg gtg gaa gaa cac ctc acc gcc ttg gaa gct 163Leu Ala Leu Gln Gly Gly Val Glu Glu His Leu Thr Ala Leu Glu Ala

10 15 20ctc gga gcg acg acc cga aaa gta cgt gtg cca aag gac ctt gat ggt 211Leu Gly Ala Thr Thr Arg Lys Val Arg Val Pro Lys Asp Leu Asp Gly

25 30 35ctc gaa ggc atc gtc atc ccc ggc ggg gaa tcc acc gtg ttg gac aaa 259Leu Glu Gly Ile Val Ile Pro Gly Gly Glu Ser Thr Val Leu Asp Lys

40 45 50ctg gct cgg aca ttc gac gtg gta gaa cct cta gcg aat ctc att cgc 307Leu Ala Arg Thr Phe Asp Val Val Glu Pro Leu Ala Asn Leu Ile Arg

55 60 65gac ggc cta ccc gtt ttc gct acc tgc gct ggc ctg atc tat ctg gcg 355Asp Gly Leu Pro Val Phe Ala Thr Cys Ala Gly Leu Ile Tyr Leu Ala 70 75 80 85aaa cac ctc gac aac cca gca agg gga caa caa acc ttg gcg gta gtg 403Lys His Leu Asp Asn Pro Ala Arg Gly Gln Gln Thr Leu Ala Val Val

90 95 100gac gtg gtg gtg cgt cga aac gca ttt ggc gcc caa cgc gaa tcc ttc 451Asp Val Val Val Arg Arg Asn Ala Phe Gly Ala Gln Arg Glu Ser Phe

105 110 115gac acc acc gtg gat gtt tcc ttc gac ggt gca aca ttc ccc gga gtg 499Asp Thr Thr Val Asp Val Ser Phe Asp Gly Ala Thr Phe Pro Gly Val

120 125 130cag gcc tcg ttt atc cga gct ccc atc gtc act gct ttt ggt cct acg 547Gln Ala Ser Phe Ile Arg Ala Pro Ile Val Thr Ala Phe Gly Pro Thr

135140145 gta gaa gcg atc gct gct ctc aac ggt ggg gag gtg gtt ggt gta cgc 595Val Glu Ala Ile Ala Ala Leu Asn Gly Gly Glu Val Val Gly Val Arg 150155160165 caa ggc 601Gln Gly<210>388<211>167<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>388Val Ile Val Gly Val Leu Ala Leu Gln Gly Gly Val Glu Glu His Leu 151015 Thr Ala Leu Glu Ala Leu Gly Ala Thr Thr Arg Lys Val Arg Val Pro

20 25 30Lys Asp Leu Asp Gly Leu Glu Gly Ile Val Ile Pro Gly Gly Glu Ser

35 40 45Thr Val Leu Asp Lys Leu Ala Arg Thr Phe Asp Val Val Glu Pro Leu

50 55 60Ala Asn Leu Ile Arg Asp Gly Leu Pro Val Phe Ala Thr Cys Ala Gly 65 70 75 80Leu Ile Tyr Leu Ala Lys His Leu Asp Asn Pro Ala Arg Gly Gln Gln

85 90 95Thr Leu Ala Val Val Asp Val Val Val Arg Arg Asn Ala Phe Gly Ala

100 105 110Gln Arg Glu Ser Phe Asp Thr Thr Val Asp Val Ser Phe Asp Gly Ala

115 120 125Thr Phe Pro Gly Val Gln Ala Ser Phe Ile Arg Ala Pro Ile Val Thr

130 135 140Ala Phe Gly Pro Thr Val Glu Ala Ile Ala Ala Leu Asn Gly Gly Glu145 150 155 160Val Val Gly Val Arg Gln Gly

165<210>389<21l>897<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<874><223>RXA01098<400>389aaaagggctc acgatgtgct gttaagtaag attgaaaaag ttcggttgat gcatgcagat 60gcaggtaatg accagtcgtt aaatgaggag tacaagtaaa atg ggc gtg gca att 115

Met Gly Val Ala Ile

1 5cga gtt att cct tgc ctg gac gtg gac aac ggc cgg gtt gtt aaa ggc 163Arg Val Ile Pro Cys Leu Asp Val Asp Asn Gly Arg Val Val Lys Gly

10 15 20gtg aac ttt gaa aac ctc cgc gat gct ggc gat cct gtg gag ttg gca 211Val Asn Phe Glu Asn Leu Arg Asp Ala Gly Asp Pro Val Glu Leu Ala

25 30 35aag cgc tat gac gag gaa ggg gca gat gag ctg acc ttc ctg gat gtc 259Lys Arg Tyr Asp Glu Glu Gly Ala Asp Glu Leu Thr Phe Leu Asp Val

40 45 50acc gcc tcg aag cat ggt cgc ggc acc atg ctg gat gtt gtt cga cgc 307Thr Ala Ser Lys His Gly Arg Gly Thr Met Leu Asp Val Val Arg Arg

55 60 65acc gct gat cag gtg ttc atc cct ctg act gtc ggt ggc ggc gtg cgc 355Thr Ala Asp Gln Val Phe Ile Pro Leu Thr Val Gly Gly Gly Val Arg 70 75 80 85agc gaa gaa gat gtt gat caa ttg ctg cgc gct ggc gcc gac aag gtt 403Ser Glu Glu Asp Val Asp Gln Leu Leu Arg Ala Gly Ala Asp Lys Val

90 95 100tcg gtg aac acg tct gcg att gcc cgt cca gaa ctg ctg tca gag ctg 451Ser Val Asn Thr Ser Ala Ile Ala Arg Pro Glu Leu Leu Ser Glu Leu

105 110 115tcc aag cgt ttt ggt gct cag tgc atc gtg ttg tct gtg gat gcc agg 499Ser Lys Arg Phe Gly Ala Gln Cys Ile Val Leu Ser Val Asp Ala Arg

120 125 130cgc gtt cct gaa ggt gga act cct cag cca tct ggt ttt gaa gtc acc 547Arg Val Pro Glu Gly Gly Thr Pro Gln Pro Ser Gly Phe Glu Val Thr

135 140 145acc cac ggc ggt tcc aag tcc gca gaa ctt gat gca atc gag tgg gca 595Thr His Gly Gly Ser Lys Ser Ala Glu Leu Asp Ala Ile Glu Trp Ala150 155 160 165aag cgc ggc gaa gag ctg ggc gtt ggc gaa att ctg ctc aac tcc atg 643Lys Arg Gly Glu Glu Leu Gly Val Gly Glu Ile Leu Leu Asn Ser Met

170 175 180gac ggc gac ggc acc aaa aac ggc ttt gac cta gag ctg ctg gaa aaa 691Asp Gly Asp Gly Thr Lys Asn Gly Phe Asp Leu Glu Leu Leu Glu Lys

185 190 195gtt cgc gca gcc gta tcc att cct gta atc gcc tcc ggc ggc gct ggc 739Val Arg Ala Ala Val Ser Ile Pro Val Ile Ala Set Gly Gly Ala Gly

200 205 210aag gcg gag cat ttc cca cca gct gtt gca gct ggc gcc aac gca gtg 787Lys Ala Glu His Phe Pro Pro Ala Val Ala Ala Gly Ala Asn Ala Val

215 220 225ctt gcc gcg acc att ttc cac ttc cgc gaa gta acc atc gcc gaa gta 835Leu Ala Ala Thr Ile Phe His Phe Arg Glu Val Thr Ile Ala Glu Val230 235 240 245aag gga gcc att aaa gat gca gga ttt gag gtg cgg aaa tgagtgacaa 884Lys Gly Ala Ile Lys Asp Ala Gly Phe Glu Val Arg Lys

250255 tccacaagag tat 897<210>390<211>258<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>390Met Gly Val Ala Ile Arg Val Ile Pro Cys Leu Asp Val Asp Asn Gly 151015 Arg Val Val Lys Gly Val Asn Phe Glu Asn Leu Arg Asp Ala Gly Asp

20 25 30Pro Val Glu Leu Ala Lys Arg Tyr Asp Glu Glu Gly Ala Asp Glu Leu

35 40 45Thr Phe Leu Asp Val Thr Ala Ser Lys His Gly Arg Gly Thr Met Leu

50 55 60Asp Val Val Arg Arg Thr Ala Asp Gln Val Phe Ile Pro Leu Thr Val 65 70 75 80Gly Gly Gly Val Arg Ser Glu Glu Asp Val Asp Gln Leu Leu Arg Ala

85 90 95Gly Ala Asp Lys Val Ser Val Asn Thr Ser Ala Ile Ala Arg Pro Glu

100 105 110Leu Leu Ser Glu Leu Ser Lys Arg Phe Gly Ala Gln Cys Ile Val Leu

115 120 125Ser Val Asp Ala Arg Arg Val Pro Glu Gly Gly Thr Pro Gln Pro Ser

130 135 140Gly Phe Glu Val Thr Thr His Gly Gly Ser Lys Ser Ala Glu Leu Asp145 150 155 160Ala Ile Glu Trp Ala Lys Arg Gly Glu Glu Leu Gly Val Gly Glu Ile

165 170 175Leu Leu Asn Ser Met Asp Gly Asp Gly Thr Lys Asn Gly Phe Asp Leu

180 185 190Glu Leu Leu Glu Lys Val Arg Ala Ala Val Ser Ile Pro Val Ile Ala

195 200 205Ser Gly Gly Ala Gly Lys Ala Glu His Phe Pro Pro Ala Val Ala Ala

210 215 220Gly Ala Asn Ala Val Leu Ala Ala Thr Ile Phe His Phe Arg Glu Val225 230 235 240Thr Ile Ala Glu Val Lys Gly Ala Ile Lys Asp Ala Gly Phe Glu Val

245250255 Arg Lys<210>391<211>729<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<706>RXN01104<400>391cacttgcgca ctaccattgg tgtgcctgag gaaaatgatg cgtttttgga cgcagctgca 60gagatcatca agctgaacct gtaagagaga agaatttttc atg act gtc gca cca 115

Met Thr Val Ala Pro

l 5aga att ggt acc gca acc cgc acc acc agc gaa tcc gac atc acc gtc 163Arg Ile Gly Thr Ala Thr Arg Thr Thr Ser Glu Ser Asp Ile Thr Val

10 15 20gag atc aac ctg gac ggc acc ggc aaa gta gat atc gat acc ggc ctg 211Glu Ile Asn Leu Asp Gly Thr Gly Lys Val Asp Ile Asp Thr Gly Leu

25 30 35cca ttt ttc gac cac atg ctc act gca ttc ggc gtg cac ggc agt ttt 259Pro Phe Phe Asp His Met Leu Thr Ala Phe Gly Val His Gly Ser Phe

40 45 50gat ctg aaa gtc cat gcc aag ggc gac atc gag atc gac gca cac cac 307Asp Leu Lys Val His Ala Lys Gly Asp Ile Glu Ile Asp Ala His His

55 60 65acc gtg gaa gat acc gcc atc gtg ctc ggc caa gca ctc ctt gac gct 355Thr Val Glu Asp Thr Ala Ile Val Leu Gly Gln Ala Leu Leu Asp Ala 70 75 80 85att ggc gac aag aaa ggc atc cgc cgt ttc gca tcc tgc cag ctg ccc 403Ile Gly Asp Lys Lys Gly Ile Arg Arg Phe Ala Ser Cys Gln Leu Pro

90 95 100atg gat gag gca tta gtg gag tcc gtg gtg gat atc tcc ggt cgc cca 451Met Asp Glu Ala Leu Val Glu Ser Val Val Asp Ile Ser Gly Arg Pro

105 110 115tac ttc gtg atc tcc ggc gaa cca gac cac atg atc acc tcc gtg atc 499Tyr Phe Val Ile Ser Gly Glu Pro Asp His Met Ile Thr Ser Val Ile

120 125 130ggt gga cac tac gca acc gtg atc aac gag cacttc ttt gaa acc ctc 547Gly Gly His Tyr Ala Thr Val Ile Asn Glu His Phe Phe Glu Thr Leu

135 140 145gcg ctc aac tcc cga atc acc ctc cac gtg atc tgc cac tac ggc cgc 595Ala Leu Asn Ser Arg Ile Thr Leu His Val Ile Cys His Tyr Gly Arg150 155 160 165gac cct cac cac atc acc gaa gca gag tac aag gct gtt gcc cgt gcg 643Asp Pro His His Ile Thr Glu Ala Glu Tyr Lys Ala Val Ala Arg Ala

170 175 180ctg cgc ggt gcc gta gag atg gat cct cgt caa aca gga atc cca tcc 691Leu Arg Gly Ala Val Glu Met Asp Pro Arg Gln Thr Gly Ile Pro Ser

185 190 195act aag gga gcg ctc tagacatgaa ctcttctccc atc 729Thr Lys Gly Ala Leu

200<210>392<211>202<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>392Met Thr Val Ala Pro Arg Ile Gly Thr Ala Thr Arg Thr Thr Ser Glu 151015 Ser Asp Ile Thr Val Glu Ile Asn Leu Asp Gly Thr Gly Lys Val Asp

20 25 30Ile Asp Thr Gly Leu Pro Phe Phe Asp His Met Leu Thr Ala Phe Gly

35 40 45Val His Gly Ser Phe Asp Leu Lys Val His Ala Lys Gly Asp Ile Glu

50 55 60Ile Asp Ala His His Thr Val Glu Asp Thr Ala Ile Val Leu Gly Gln 65 70 75 80Ala Leu Leu Asp Ala Ile Gly Asp Lys Lys Gly Ile Arg Arg Phe Ala

85 90 95Ser Cys Gln Leu Pro Met Asp Glu Ala Leu Val Glu SerVal Val Asp

100 105 110Ile Ser Gly Arg Pro Tyr Phe Val Ile Ser Gly Glu Pro Asp His Met

115 120 125Ile Thr Ser Val Ile Gly Gly His Tyr Ala Thr Val Ile Asn Glu His

130 135 140Phe Phe Glu Thr Leu Ala Leu Asn Ser Arg Ile Thr Leu His Val Ile145 150 155 160Cys His Tyr Gly Arg Asp Pro His His Ile Thr Glu Ala Glu Tyr Lys

165 170 175Ala Val Ala Arg Ala Leu Arg Gly Ala Val Glu Met Asp Pro Arg Gln

180 185 190Thr Gly Ile Pro Ser Thr Lys Gly Ala Leu

195200<210>393<211>729<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (706)<223>FRXA01104<400>393cacttgcgca ctaccattgg tgtgcctgag gaaaatgatg cgtttttgga cgcagctgca 60gagatcatca agctgaacct gtaagagaga agaatttttc atg act gtc gca cca 115

Met Thr Val Ala Pro

1 5aga att ggt acc gca acc cgc acc acc agc gaa tcc gac atc acc gtc 163Arg Ile Gly Thr Ala Thr Arg Thr Thr Ser Glu Ser Asp Ile Thr Val

10 15 20gag atc aac ctg gac ggc acc ggc aaa gta gat atc gat acc ggc ctg 211Glu Ile Asn Leu Asp Gly Thr Gly Lys Val Asp Ile Asp Thr Gly Leu

25 30 35cca ttt ttc gac cac atg ctc act gca ttc ggc gtg cac ggc agt ttt 259Pro Phe Phe Asp His Met Leu Thr Ala Phe Gly ValHis Gly Ser Phe

40 45 50gat ctg aaa gtc cat gcc aag ggc gac atc gag atc gac gca cac cac 307Asp Leu Lys Val His Ala Lys Gly Asp Ile Glu Ile Asp Ala His His

55 60 65acc gtg gaa gat acc gcc atc gtg ctc ggc caa gca ctc ctt gac gct 355Thr Val Glu Asp Thr Ala Ile Val Leu Gly Gln Ala Leu Leu Asp Ala 70 75 80 85att ggc gac aag aaa ggc atc cgc cgt ttc gca tcc tgc cag ctg ccc 403Ile Gly Asp Lys Lys Gly Ile Arg Arg Phe Ala Ser Cys Gln Leu Pro

90 95 100atg gat gag gca tta gtg gag tcc gtg gtg gat atc tcc ggt cgc cca 451Met Asp Glu Ala Leu Val Glu Ser Val Val Asp Ile Ser Gly Arg Pro

105 110 115tac ttc gtg atc tcc ggc gaa cca gac cac atg atc acc tcc gtg atc 499Tyr Phe Val Ile Ser Gly Glu Pro Asp His Met Ile Thr Ser Val Ile

120 125 130ggt gga cac tac gca acc gtg atc aac gag cac ttc ttt gaa acc ctc 547Gly Gly His Tyr Ala Thr Val Ile Asn Glu His Phe Phe Glu Thr Leu

135 140 145gcg ctc aac tcc cga atc acc ctc cac gtg atc tgc cac tac ggc cgc 595Ala Leu Asn Ser Arg Ile Thr Leu His Val Ile Cys His Tyr Gly Arg150 155 160 165gac cct cac cac atc acc gaa gca gag tac aag gct gtt gcc cgt gcg 643Asp Pro His His Ile Thr Glu Ala Glu Tyr Lys Ala Val Ala Arg Ala

170 175 180ctg cgc ggt gcc gta gag atg gat cct cgt caa aca gga atc cca tcc 691Leu Arg Gly Ala Val Glu Met Asp Pro Arg Gln Thr Gly Ile Pro Set

185 190 195act aag gga gcg ctc tagacatgaa ctcttctccc atc 729Thr Lys Gly Ala Leu

200<210>394<211>202<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>394Met Thr Val Ala Pro Arg Ile Gly Thr Ala Thr Arg Thr Thr Ser Glu 151015 Ser Asp Ile Thr Val Glu Ile Asn Leu Asp Gly Thr Gly Lys Val Asp

20 25 30Ile Asp Thr Gly Leu Pro Phe Phe Asp His Met Leu Thr Ala Phe Gly

35 40 45Val His Gly Ser Phe Asp Leu Lys Val His Ala Lys Gly Asp Ile Glu

50 55 60Ile Asp Ala His His Thr Val Glu Asp Thr Ala Ile Val Leu Gly Gln 65 70 75 80Ala Leu Leu Asp Ala Ile Gly Asp Lys Lys Gly Ile Arg Arg Phe Ala

85 90 95Ser Cys Gln Leu Pro Met Asp Glu Ala Leu Val Glu Ser Val Val Asp

100 105 110Ile Ser Gly Arg Pro Tyr Phe Val Ile Ser Gly Glu Pro Asp His Met

115 120 125Ile Thr Ser Val Ile Gly Gly His Tyr Ala Thr Val Ile Asn Glu His

130 135 140Phe Phe Glu Thr Leu Ala Leu Asn Ser Arg Ile Thr Leu His Val Ile145 150 155 160Cys His Tyr Gly Arg Asp Pro His His Ile Thr Glu Ala Glu Tyr Lys

165 170 175Ala Val Ala Arg Ala Leu Arg Gly Ala Val Glu Met Asp Pro Arg Gln

180 185 190Thr Gly Ile Pro Ser Thr Lys Gly Ala Leu

195200<210>395<211>987<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (964)<223>RXN00446<400>395tgctacgaag ttatctagta atgaagttag tttttcccct ctcccggcag cagttgatgc 60ggtgacggag gctacttggg gggctaatcg gtacccggat atg ggt gcg gtt gag 115

Met Gly Ala Val Glu

1 5ctc cgt gag gct ctt gca gag cat tta gag gtt gag ttt gac cag gtc 163Leu Arg Glu Ala Leu Ala Glu His Leu Glu Val Glu Phe Asp Gln Val

10 15 20acg gta ggt tgc ggc tcg tct gcg ctg tgt caa cag ctg gtt cag gca 211Thr Val Gly Cys Gly Ser Ser Ala Leu Cys Gln Gln Leu Val Gln Ala

25 30 35acg tgc gct cag ggc gat gag gtc att ttt cca tgg cgc agc ttt gag 259Thr Cys Ala Gln Gly Asp Glu Val Ile Phe Pro Trp Arg Ser Phe Glu

40 45 50gct tat cca att ttc gcg cag gtc gcg ggc gcc act cct gtt gcc att 307Ala Tyr Pro Ile Phe Ala Gln Val Ala Gly Ala Thr Pro Val Ala Ile

55 60 65ccg ctg act gct gat cag aat cat gat ctt gat gcg atg gca gcc gcg 355Pro Leu Thr Ala Asp Gln Asn His Asp Leu Asp Ala Met Ala Ala Ala 70 75 80 85atc act gat aag acc cgc ctc att ttc atc tgc aac ccc aac aat cct 403Ile Thr Asp Lys Thr Arg Leu Ile Phe Ile Cys Asn Pro Asn Asn Pro

90 95 100tcg ggc ace acc atc acc cag gcg cag ttt gat aat ttc atg gaa aag 451Ser Gly Thr Thr Ile Thr Gln Ala Gln Phe Asp Asn Phe Met Glu Lys

105 110 115gtt cca aac gat gtc gtt gtt ggg ctg gat gag gct tat ttt gag ttc 499Val Pro Asn Asp Val Val Val Gly Leu Asp Glu Ala Tyr Phe Glu Phe

120 125 130aac cgc gcg gac gac acc cca gtt gcc act gag gaa atc cac cgc cac 547Asn Arg Ala Asp Asp Thr Pro Val Ala Thr Glu Glu Ile His Arg His

135 140 145gac aac gtg att ggt ttg cgc acg ttc tcc aag gcg tat ggc ctg gcg 595Asp Asn Val Ile Gly Leu Arg Thr Phe Ser Lys Ala Tyr Gly Leu Ala150 155 160 165ggc ttg cgt gtt ggt tac gcc ttc gga aac gca gag atc atc gca gcg 643Gly Leu Arg Val Gly Tyr Ala Phe Gly Asn Ala Glu Ile Ile Ala Ala

170 175 180atg aat aag gtg gct att cct ttc gcg gtg aat tca gca gct cag gcg 691Met Asn Lys Val Ala Ile Pro Phe Ala Val Asn Sec Ala Ala Gln Ala

185 190 195gca gcg ctt gcg agt ttg aat tct gcc gat gag ttg atg gaa cgg gtg 739Ala Ala Leu Ala Sec Leu Asn Ser Ala Asp Glu Leu Met Glu Arg Val

200 205 210gag gaa acc gtc gaa aag cgt gat gct gtg gtg tca gcg ctt ggt gct 787Glu Glu Thr Val Glu Lys Arg Asp Ala Val Val Sec Ala Leu Gly Ala

215 220 225gcg ccg acg cag gcc aat ttc gtc tgg ctg ccg ggc gag ggc gcc gct 835Ala Pro Thr Gln Ala Asn Phe Val Trp Leu Pro Gly Glu Gly Ala Ala230 235 240 245gag ttg gcg gct aaa ttg gcc gag cac ggc atc gtg att cgc gcg ttc 883Glu Leu Ala Ala Lys Leu Ala Glu His Gly Ile Val Ile Arg Ala Phe

250 255 260ccc gag ggt gcg cgc att tcg gtg acc aac gcc gag gaa act gac aag 931Pro Glu Gly Ala Arg Ile Ser Val Thr Asn Ala Glu Glu Thr Asp Lys

265 270 275ctg ctg cgc gcg tgg gag gcc atc aat gct ggg tagtctttgg cgttttgcgg 984Leu Leu Arg Ala Trp Glu Ala Ile Asn Ala Gly

280285 tgc 987<210>396<211>288<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>396Met Gly Ala Val Glu Leu Arg Glu Ala Leu Ala Glu His Leu Glu Val 151015 Glu Phe Asp Gln Val Thr Val Gly Cys Gly Ser Ser Ala Leu Cys Gln

20 25 30Gln Leu Val Gln Ala Thr Cys Ala Gln Gly Asp Glu Val Ile Phe Pro

35 40 45Trp Arg Ser Phe Glu Ala Tyr Pro Ile Phe Ala Gln Val Ala Gly Ala

50 55 60Thr Pro Val Ala Ile Pro Leu Thr Ala Asp Gln Asn His Asp Leu Asp 65 70 75 80Ala Met Ala Ala Ala Ile Thr Asp Lys Thr Arg Leu Ile Phe Ile Cys

85 90 95Asn Pro Asn Asn Pro Ser Gly Thr Thr Ile Thr Gln Ala Gln Phe Asp

100 105 110Asn Phe Met Glu Lys Val Pro Asn Asp Val Val Val Gly Leu Asp Glu

115 120 125Ala Tyr Phe Glu Phe Asn Arg Ala Asp Asp Thr Pro Val Ala Thr Glu

130 135 140Glu Ile His Arg His Asp Asn Val Ile Gly Leu Arg Thr Phe Ser Lys145 150 155 160Ala Tyr Gly Leu Ala Gly Leu Arg Val Gly Tyr Ala Phe Gly Asn Ala

165 170 175Glu Ile Ile Ala Ala Met Asn Lys Val Ala Ile Pro Phe Ala Val Asn

180 185190Ser Ala Ala Gln Ala Ala Ala Leu Ala Ser Leu Asn Ser Ala Asp Glu

195 200 205Leu Met Glu Arg Val Glu Glu Thr Val Glu Lys Arg Asp Ala Val Val

210 215 220Ser Ala Leu Gly Ala Ala Pro Thr Gln Ala Asn Phe Val Trp Leu Pro225 230 235 240Gly Glu Gly Ala Ala Glu Leu Ala Ala Lys Leu Ala Glu His Gly Ile

245 250 255Val Ile Arg Ala Phe Pro Glu Gly Ala Arg Ile Ser Val Thr Asn Ala

260 265 270Glu Glu Thr Asp Lys Leu Leu Arg Ala Trp Glu Ala Ile Asn Ala Gly

275280285<210>397<211>545<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) } (522)<223>FRXA00446<400>397<397atg gaa aag gtt cca aac gat gtc gtt gtt ggg ctg gat gag gct tat 48Met Glu Lys Val Pro Asn Asp Val Val Val Gly Leu Asp Glu Ala Tyr 151015 ttt gag ttc aac cgc gcg gac gac acc cca gtt gcc act gag gaa atc 96Phe Glu Phe Asn Arg Ala Asp Asp Thr Pro Val Ala Thr Glu Glu Ile

20 25 30cac cgc cac gac aac gtg att ggt ttg cgc acg ttc tcc aag gcg tat 144His Arg His Asp Asn Val Ile Gly Leu Arg Thr Phe Ser Lys Ala Tyr

35 40 45ggc ctg gcg ggc ttg cgt gtt ggt tac gcc ttc gga aac gca gag atc 192Gly Leu Ala Gly Leu Arg Val Gly Tyr Ala Phe Gly Asn Ala Glu Ile

50 55 60atc gca gcg atg aat aag gtg gct att cct ttc gcg gtg aat tca gca 240Ile Ala Ala Met Asn Lys Val Ala Ile Pro Phe Ala Val Asn Ser Ala 65 70 75 80gct cag gcg gca gcg ctt gcg agt ttg aat tct gcc gat gag ttg atg 288Ala Gln Ala Ala Ala Leu Ala Ser Leu Asn Ser Ala Asp Glu Leu Met

85 90 95gaa cgg gtg gag gaa acc gtc gaa aag cgt gat gct gtg gtg tca gcg 336Glu Arg Val Glu Glu Thr Val Glu Lys Arg Asp Ala Val Val Ser Ala

100 105 110ctt ggt gct gcg ccg acg cag gcc aat ttc gtc tgg ctg ccg ggc gag 384Leu Gly Ala Ala Pro Thr Gln Ala Asn Phe Val Trp Leu Pro Gly Glu

115 120 125ggc gcc gct gag ttg gcg gct aaa ttg gcc gag cac ggc atc gtg att 432Gly Ala Ala Glu Leu Ala Ala Lys Leu Ala Glu His Gly Ile Val Ile

130 135 140cgc gcg ttc ccc gag ggt gcg cgc att tcg gtg acc aac gcc gag gaa 480Arg Ala Phe Pro Glu Gly Ala Arg Ile Ser Val Thr Asn Ala Glu Glu145 150 155 160act gac aag ctg ctg cgc gcg tgg gag gcc atc aat gct ggg 522Thr Asp Lys Leu Leu Arg Ala Trp Glu Ala Ile Asn Ala Gly

165170 tagtctttgg cgttttgcgg tgc 545<210>398<211>174<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>398Met Glu Lys Val Pro Asn Asp Val Val Val Gly Leu Asp Glu Ala Tyr l 51015 Phe Glu Phe Asn Arg Ala Asp Asp Thr Pro Val Ala Thr Glu Glu Ile

20 25 30His Arg His Asp Asn Val Ile Gly Leu Arg Thr Phe Ser Lys Ala Tyr

35 40 45Gly Leu Ala Gly Leu Arg Val Gly Tyr Ala Phe Gly Asn Ala Glu Ile

50 55 60Ile Ala Ala Met Asn Lys Val Ala Ile Pro Phe Ala Val Asn Ser Ala 65 70 75 80AlaGln Ala Ala Ala Leu Ala Ser Leu Asn Ser Ala Asp Glu Leu Met

85 90 95Glu Arg Val Glu Glu Thr Val Glu Lys Arg Asp Ala Val Val Ser Ala

100 105 110Leu Gly Ala Ala Pro Thr Gln Ala Asn Phe Val Trp Leu Pro Gly Glu

115 120 125Gly Ala Ala Glu Leu Ala Ala Lys Leu Ala Glu His Gly Ile Val Ile

130 135 140Arg Ala Phe Pro Glu Gly Ala Arg Ile Ser Val Thr Asn Ala Glu Glu145 150 155 160Thr Asp Lys Leu Leu Arg Ala Trp Glu Ala Ile Asn Ala Gly

165170<210>399<211>1221<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1198)<223>RXA01105<400>399ttgtcatcaa ctttgccaac gccgaagatc ttccagcgca cggcgaagca atccgtgcac 60gctttgaaaa cctccccacc accgacgagg cctaagaaaa atg acc aaa att act 115

Met Thr Lys Ile Thr

1 5ttg agc gat ttg cca ttg cgt gaa gaa ctg cgc ggt gag cae gct tac 163Leu Ser Asp Leu Pro Leu Arg Glu Glu Leu Arg Gly Glu His Ala Tyr

10 15 20ggc gca ccc cag ctc aac gtt gat att cgc ctc aac acc aac gaa aac 211Gly Ala Pro Gln Leu Asn Val Asp Ile Arg Leu Asn Thr Asn Glu Asn

25 30 35cct tac cca ccg tca gag gca ttg gtc gct gac ttg gtt gcc acc gtg 259Pro Tyr Pro Pro Ser Glu Ala Leu Val Ala Asp Leu Val Ala Thr Val

40 45 50gat aag atc gcc acc gag ctgaac cgc tac cca gag cgc gat gct gtg 307Asp Lys Ile Ala Thr Glu Leu Asn Arg Tyr Pro Glu Arg Asp Ala Val

55 60 65gaa ctg cgt gat gag ttg gct gcg tac atc acc aag caa acc ggc gtg 355Glu Leu Arg Asp Glu Leu Ala Ala Tyr Ile Thr Lys Gln Thr Gly Val 70 75 80 85gct gtc acc agg gat aac ctg tgg gct gcc aat ggt tcc aat gaa att 403Ala Val Thr Arg Asp Asn Leu Trp Ala Ala Asn Gly Ser Asn Glu Ile

90 95 100ctg cag cag ctg ctg cag gct ttt ggt gga cct gga cgc acc gcg ttg 451Leu Gln Gln Leu Leu Gln Ala Phe Gly Gly Pro Gly Arg Thr Ala Leu

105 110 115gga ttc caa ccc agc tat tcc atg cac cca att ttg gct aaa ggc acc 499Gly Phe Gln Pro Ser Tyr Ser Met His Pro Ile Leu Ala Lys Gly Thr

120 125 130cac act gaa ttc att gcg gtg tcc cga ggt gct gat ttc cgc atc gat 547His Thr Glu Phe Ile Ala Val Ser Arg Gly Ala Asp Phe Arg Ile Asp

135 140 145atg gat gtg gcg ctg gaa gaa att cgt gca aag cag cct gac att gtt 595Met Asp Val Ala Leu Glu Glu Ile Arg Ala Lys Gln Pro Asp Ile Val150 155 160 165ttt gtc acc acc ccg aac aac ccg acc ggt gat gtg acc tcg ctg gac 643Phe Val Thr Thr Pro Asn Asn Pro Thr Gly Asp Val Thr Ser Leu Asp

170 175 180gat gtt gag cgc atc atc aac gtt gcc cca ggc atc gtg atc gtg gat 691Asp Val Glu Arg Ile Ile Asn Val Ala Pro Gly Ile Val Ile Val Asp

185 190 195gaa gct tat gcg gaa ttc tcc cca tca cct tca gca acc act ctt ctg 739Glu Ala Tyr Ala Glu Phe Ser Pro Ser Pro Ser Ala Thr Thr Leu Leu

200 205 210gag aag tac cca acc aag ctg gtg gtg tcc cgc acc atg agt aag gct 787Glu Lys Tyr Pro Thr Lys Leu Val Val Ser Arg Thr Met Ser Lys Ala

215 220 225ttt gat ttc gca ggt gga cgc ctc ggc tac ttc gtg gcc aac cca gcg 835Phe Asp Phe Ala Gly Gly Arg Leu Gly Tyr Phe Val Ala Asn Pro Ala230 235 240 245ttt atc gac gcc gtg atg cta gtc cgc ctt ccg tat cat ctt tca gcg 883Phe Ile Asp Ala Val Met Leu Val Arg Leu Pro Tyr His Leu Ser Ala

250 255 260ctg agc caa gca gcc gca atc gta gcg ctg cgt cac tcc gct gac acg 931Leu Ser Gln Ala Ala Ala Ile Val Ala Leu Arg His Ser Ala Asp Thr

265 270 275ctg gga acc gtc gaa aag ctc tct gta gag cgt gtt cgc gtg gca gca 979Leu Gly Thr Val Glu Lys Leu Ser Val Glu Arg Val Arg Val Ala Ala

280 285 290cgc ttg gag gaa ctg ggc tac gct gtg gtt cca agt gag tcc aac ttt 1027Arg Leu Glu Glu Leu Gly Tyr Ala Val Val Pro Ser Glu Ser Asn Phe

295 300 305gtg ttc ttt gga gat ttc tcc gat cag cac gcg gca tgg cag gca ttt 1075Val Phe Phe Gly Asp Phe Ser Asp Gln His Ala Ala Trp Gln Ala Phe310 315 320 325ttg gat agg gga gtg ctc atc cgc gat gtg gga atc gct ggg cac ttg 1123Leu Asp Arg Gly Val Leu Ile Arg Asp Val Gly Ile Ala Gly His Leu

330 335 340cgc act acc att ggt gtg cct gag gaa aat gat gcg ttt ttg gac gca 1171Arg Thr Thr Ile Gly Val Pro Glu Glu Asn Asp Ala Phe Leu Asp Ala

345 350 355get gca gag atc atc aag ctg aacctg taagagagaa gaatttttca 1218Ala Ala Glu Ile Ile Lys Leu Asn Leu

360365 tga 1221<210>400<211>366<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>400Met Thr Lys Ile Thr Leu Ser Asp Leu Pro Leu Arg Glu Glu Leu Arg 151015 Gly Glu His Ala Tyr Gly Ala Pro Gln Leu Asn Val Asp Ile Arg Leu

20 25 30Asn Thr Asn Glu Asn Pro Tyr Pro Pro Ser Glu Ala Leu Val Ala Asp

35 40 45Leu Val Ala Thr Val Asp Lys Ile Ala Thr Glu Leu Asn Arg Tyr Pro

50 55 60Glu Arg Asp Ala Val Glu Leu Arg Asp Glu Leu Ala Ala Tyr Ile Thr 65 70 75 80Lys Gln Thr Gly Val Ala Val Thr Arg Asp Asn Leu Trp Ala Ala Asn

85 90 95Gly Ser Asn Glu Ile Leu Gln Gln Leu Leu Gln Ala Phe Gly Gly Pro

100 105 110Gly Arg Thr Ala Leu Gly Phe Gln Pro Ser Tyr Ser Met His Pro Ile

115 120 125Leu Ala Lys Gly Thr His Thr Glu Phe Ile Ala Val Ser Arg Gly Ala

130 135 140Asp Phe Arg Ile Asp Met Asp Val Ala Leu Glu Glu Ile Arg Ala Lys145 150 155 160Gln Pro Asp Ile Val Phe Val Thr Thr Pro Asn Asn Pro Thr Gly Asp

165 170 175Val Thr Ser Leu Asp Asp Val Glu Arg Ile Ile Asn Val Ala Pro Gly

180 185 190Ile Val Ile Val Asp Glu Ala Tyr Ala Glu Phe Ser Pro Ser Pro Ser

195200 205Ala Thr Thr Leu Leu Glu Lys Tyr Pro Thr Lys Leu Val Val Ser Arg

210 215 220Thr Met Ser Lys Ala Phe Asp Phe Ala Gly Gly Arg Leu Gly Tyr Phe225 230 235 240Val Ala Asn Pro Ala Phe Ile Asp Ala Val Met Leu Val Arg Leu Pro

245 250 255Tyr His Leu Ser Ala Leu Ser Gln Ala Ala Ala Ile Val Ala Leu Arg

260 265 270His Ser Ala Asp Thr Leu Gly Thr Val Glu Lys Leu Ser Val Glu Arg

275 280 285Val Arg Val Ala Ala Arg Leu Glu Glu Leu Gly Tyr Ala Val Val Pro

290 295 300Ser Glu Ser Asn Phe Val Phe Phe Gly Asp Phe Ser Asp Gln His Ala305 310 315 320Ala Trp Gln Ala Phe Leu Asp Arg Gly Val Leu Ile Arg Asp Val Gly

325 330 335Ile Ala Gly His Leu Arg Thr Thr Ile Gly Val Pro Glu Glu Asn Asp

340 345 350Ala Phe Leu Asp Ala Ala Ala Glu Ile Ile Lys Leu Asn Leu

355360365<210>401<211>1449<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1426)<223>RXA01106<400>401ggtaaacatg cgggcttaag aacttgtgtt gaggccgctt ggattcgggc accgagctcg 60aagaatttcg attcaacctt ttaagggaga acttttcgcc atg ttg aat gtc act 115

Met Leu Asn Val Thr

1 5gac ctg cga ggt caa aca cca tcc aag agc gac atc cga cgt gct ttg 163Asp Leu Arg Gly Gln Thr Pro Ser Lys Ser Asp Ile Arg Arg Ala Leu

10 15 20cca cgt ggt ggc act gac gtg tgg tct gtg ctt ccc ata gtg cag cct 211Pro Arg Gly Gly Thr Asp Val Trp Ser Val Leu Pro Ile Val Gln Pro

25 30 35gtt gta gaa gat gtc caa aac cgc ggc gct gaa gct gct ttg gat tac 259Val Val Glu Asp Val Gln Asn Arg Gly Ala Glu Ala Ala Leu Asp Tyr

40 45 50ggc gag aag ttc gac cat att cgc ccc gcc tcg gtg cgg gtg cca gct 307Gly Glu Lys Phe Asp His Ile Arg Pro Ala Ser Val Arg Val Pro Ala

55 60 65gag gtt att gct gca gca gaa aac acc tta gat ccg ttg gtg cgt gaa 355Glu Val Ile Ala Ala Ala Glu Asn Thr Leu Asp Pro Leu Val Arg Glu 70 75 80 85tcg att gaa gag tcg att cgt cgc gtc cgc aag gtt cac gct gag caa 403Ser Ile Glu Glu Ser Ile Arg Arg Val Arg Lys Val His Ala Glu Gln

90 95 100aag cca tcc gag cac acc act gaa ctt tca cca ggt ggc acc gtc act 451Lys Pro Ser Glu His Thr Thr Glu Leu Ser Pro Gly Gly Thr Val Thr

105 110 115gag cgt ttc atg ccg att gat cgc gtg gga ctg tac gtt cca ggc ggc 499Glu Arg Phe Met Pro Ile Asp Arg Val Gly Leu Tyr Val Pro Gly Gly

120 125 130aat gcg gtg tac cca tca agc gtg att atg aat act gtc cca gct caa 547Asn Ala Val Tyr Pro Ser Ser Val Ile Met Asn Thr Val Pro Ala Gln

135 140 145gag gct ggt gtg aac tcc ctt gtg gtt gcg tcg cct cct cag gct gag 595Glu Ala Gly Val Asn Ser Leu Val Val Ala Ser Pro Pro Gln Ala Glu150 155160 165cac ggt ggc tgg cct cac ccc acc att ttg gcg gcg tgt tcc atc ttg 643His Gly Gly Trp Pro His Pro Thr Ile Leu Ala Ala Cys Ser Ile Leu

170 175 180ggt gtt gat gag gtg tgg gct gtc ggc ggc ggt cag gcc gtg gcg ttg 691Gly Val Asp Glu Val Trp Ala Val Gly Gly Gly Gln Ala Val Ala Leu

185 190 195ctg gct tat ggt gat gac gct gca ggt ctc gag cct gtg gat atg atc 739Leu Ala Tyr Gly Asp Asp Ala Ala Gly Leu Glu Pro Val Asp Met Ile

200 205 210act gga cct ggc aat atc ttt gtc acc gct gcg aag cgc ctg gtc agg 787Thr Gly Pro Gly Asn Ile Phe Val Thr Ala Ala Lys Arg Leu Val Arg

215 220 225gga gtg gta ggt act gat tct gag gct ggc cct aca gaa atc gct gtg 835Gly Val Val Gly Thr Asp Ser Glu Ala Gly Pro Thr Glu Ile Ala Val230 235 240 245ctt gct gat gcc tct gcc aac gcc gtc aac gtt gcc tac gat ctg atc 883Leu Ala Asp Ala Ser Ala Asn Ala Val Asn Val Ala Tyr Asp Leu Ile

250 255 260agc caa gca gaa cac gat gtc atg gct gcg tcc gtg ctc atc act gac 931Ser Gln Ala Glu His Asp Val Met Ala Ala Ser Val Leu Ile Thr Asp

265 270 275tcc gag cag ctt gcc aag gac gta aac agg gaa atc gag gcg cgt tac 979Ser Glu Gln Leu Ala Lys Asp Val Asn Arg Glu Ile Glu Ala Arg Tyr

280 285 290tca atc acg cgc aac gcc gag cgc gtc gca gaa gct ttg cgc ggg gcc 1027Ser Ile Thr Arg Asn Ala Glu Arg Val Ala Glu Ala Leu Arg Gly Ala

295 300 305cag agt ggc atc gtg ctt gtc gac gac att tcc gtg ggt atccaa gta 1075Gln Ser Gly Ile Val Leu Val Asp Asp Ile Ser Val Gly Ile Gln Val310 315 320 325gcc gat caa tac gca gcg gaa cac ctg gaa atc cac act gag aac gcg 1123Ala Asp Gln Tyr Ala Ala Glu His Leu Glu Ile His Thr Glu Asn Ala

330 335 340cgc gcc gta gca gag cag atc acc aac gcg ggt gcg atc ttc gtg ggc 1171Arg Ala Val Ala Glu Gln Ile Thr Asn Ala Gly Ala Ile Phe Val Gly

345 350 355gat ttc tca cca gta cca ctg ggt gat tac tcc gca gga tcc aac cac 1219Asp Phe Ser Pro Val Pro Leu Gly Asp Tyr Ser Ala Gly Ser Asn His

360 365 370gtg ctg cca acc tct gga tcc gct cgt ttc tcc gca ggt cta tcc acg 1267Val Leu Pro Thr Ser Gly Ser Ala Arg Phe Ser Ala Gly Leu Ser Thr

375 380 385cac acg ttc ctt cgc cca gtc aac ctc att gaa tac gat gag gct gct 1315His Thr Phe Leu Arg Pro Val Asn Leu Ile Glu Tyr Asp Glu Ala Ala390 395 400 405ctg aag gac gtc tcg cag gtt gtc atc aac ttt gcc aac gcc gaa gat 1363Leu Lys Asp Val Ser Gln Val Val Ile Asn Phe Ala Asn Ala Glu Asp

410 415 420ctt cca gcg cac ggc gaa gca atc cgt gca cgc ttt gaa aac ctc ccc 1411Leu Pro Ala His Gly Glu Ala Ile Arg Ala Arg Phe Glu Asn Leu Pro

425 430 435acc acc gac gag gcc taagaaaaat gaccaaaatt act 1449Thr Thr Asp Glu Ala

440<210>402<211>442<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>402Met Leu Asn Val Thr Asp Leu Arg Gly Gln Thr Pro Ser Lys Ser Asp 151015 Ile Arg Arg Ala Leu Pro Arg Gly Gly Thr Asp Val Trp Ser Val Leu

20 25 30Pro Ile Val Gln Pro Val Val Glu Asp Val Gln Asn Arg Gly Ala Glu

35 40 45Ala Ala Leu Asp Tyr Gly Glu Lys Phe Asp His Ile Arg Pro Ala Ser

50 55 60Val Arg Val Pro Ala Glu Val Ile Ala Ala Ala Glu Asn Thr Leu Asp 65 70 75 80Pro Leu Val Arg Glu Ser Ile Glu Glu Ser Ile Arg Arg Val Arg Lys

85 90 95Val His Ala Glu Gln Lys Pro Ser Glu His Thr Thr Glu Leu Ser Pre

100 105 110Gly Gly Thr Val Thr Glu Arg Phe Met Pro Ile Asp Arg Val Gly Leu

115 120 125Tyr Val Pro Gly Gly Asn Ala Val Tyr Pro Ser Ser Val Ile Met Asn

130 135 140Thr Val Pro Ala Gln Glu Ala Gly Val Asn Ser Leu Val Val Ala Ser145 150 155 160Pro Pro Gln Ala Glu His Gly Gly Trp Pro His Pro Thr Ile Leu Ala

165 170 175Ala Cys Ser Ile Leu Gly Val Asp Glu Val Trp Ala Val Gly Gly Gly

180 185 190Gln Ala Val Ala Leu Leu Ala Tyr Gly Asp Asp Ala Ala Gly Leu Glu

195 200 205Pro Val Asp Met Ile Thr Gly Pro Gly Asn Ile Phe Val Thr Ala Ala

210 215 220Lys Arg Leu Val Arg Gly Val Val Gly Thr Asp Ser Glu Ala Gly Pro225 230 235 240Thr Glu Ile Ala Val Leu Ala Asp Ala Ser Ala Asn Ala Val Asn Val

245 250 255Ala Tyr Asp Leu Ile Ser Gln Ala Glu His Asp Val Met Ala Ala Ser

260 265 270Val Leu Ile Thr Asp Ser Glu Gln Leu Ala Lys Asp Val Asn Arg Glu

275 280 285Ile Glu Ala Arg Tyr Ser Ile Thr Arg Asn Ala Glu Arg Val Ala Glu

290 295 300Ala Leu Arg Gly Ala Gln Ser Gly Ile Val Leu Val Asp Asp Ile Ser305 310 315 320Val Gly Ile Gln Val Ala Asp Gln Tyr Ala Ala Glu His Leu Glu Ile

325 330 335His Thr Glu Asn Ala Arg Ala Val Ala Glu Gln Ile Thr Asn Ala Gly

340 345 350Ala Ile Phe Val Gly Asp Phe Ser Pro Val Pro Leu Gly Asp Tyr Ser

355 360 365Ala Gly Ser Asn His Val Leu Pro Thr Ser Gly Ser Ala Arg Phe Ser

370 375 380Ala Gly Leu Ser Thr His Thr Phe Leu Arg Pro Val Asn Leu Ile Glu385 390 395 400Tyr Asp Glu Ala Ala Leu Lys Asp Val Ser Gln Val Val Ile Asn Phe

405 410 415Ala Asn Ala Glu Asp Leu Pro Ala His Gly Glu Ala Ile Arg Ala Arg

420 425 430Phe Glu Asn Leu Pro Thr Thr Asp Glu Ala

435440<210>403<211>876<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (853)<223>RXC00930<400>403acggcgcacc acacatttgg tggtgtattg agctatctct gggctgcgtg agaaaccatt 60ttccggtgga tgatggaagc tagacgacga aagggagcat atg tct ggc cac tca 115

Met Ser Gly His Ser

1 5aaa tgg gcg act acc aag cac aag aag gct gct aac gac gcc aag cga 163Lys Trp Ala Thr Thr Lys His Lys Lys Ala Ala Asn Asp Ala Lys Arg

10 15 20ggc aag gaa ttt gcc aag ctg atc aag aac atc gaa gtt gcg gca cgt 211Gly Lys Glu Phe Ala Lys Leu Ile Lys Asn Ile Glu Val Ala Ala Arg

25 30 35aca ggc ggt gga gat ccg tct gcg aac cca acg ctt gat gac atg atc 259Thr Gly Gly Gly Asp Pro Ser Ala Asn Pro Thr Leu Asp Asp Met Ile

40 45 50aag aaa gcc aag aag gct tct gtg ccg aac gat aac atc gaa cgt gca 307Lys Lys Ala Lys Lys Ala Ser Val Pro Asn Asp Asn Ile Glu Arg Ala

55 60 65cgc aag cgt ggc tcc ggc gaa gaa gct ggt ggc gct gac tgg atg aac 355Arg Lys Arg Gly Ser Gly Glu Glu Ala Gly Gly Ala Asp Trp Met Asn 70 75 80 85atc atg tac gag gga tac ggc ccc aac ggc gtt gcc atg ctt atc gag 403Ile Met Tyr Glu Gly Tyr Gly Pro Asn Gly Val Ala Met Leu Ile Glu

90 95 100tgt ctg acc gac aac cgt aac cgc gca gct acc gaa gtt cgc acc gca 451Cys Leu Thr Asp Asn Arg Asn Arg Ala Ala Thr Glu Val Arg Thr Ala

105 110 115atg acc aaa aac ggt ggc aac ttg ggc gag tcc ggt tcc gtg tcc tac 499Met Thr Lys Asn Gly Gly Asn Leu Gly Glu Ser Gly Ser Val Ser Tyr

120 125 130atg ttc acc cgc acc ggt gtc gtc acc gtacaa aag ggc gat ctt agt 547Met Phe Thr Arg Thr Gly Val Val Thr Val Gln Lys Gly Asp Leu Ser

135 140 145gaa gat gac gtg ctc atg gct gtt ctt gaa gct ggt gct gaa gaa gtc 595Glu Asp Asp Val Leu Met Ala Val Leu Glu Ala Gly Ala Glu Glu Val150 155 160 165aac gac aac ggc gat ctg ttc gag gtt acc tgc gca cca act gac att 643Asn Asp Asn Gly Asp Leu Phe Glu Val Thr Cys Ala Pro Thr Asp Ile

170 175 180cag gct gtt cgc gac gca ctc gtg gaa gct ggc att gaa gta gaa gat 691Gln Ala Val Arg Asp Ala Leu Val Glu Ala Gly Ile Glu Val Glu Asp

185 190 195tct gaa tca gac ttc cgg gca tct gtt cag gtc ccc ctg gac gct gac 739Ser Glu Set Asp Phe Arg Ala Ser Val Gln Val Pro Leu Asp Ala Asp

200 205 210ggt gca cgc aag atc ttc aag ctt gtg gac gcg ttg gaa gat tcc gac 787Gly Ala Arg Lys Ile Phe Lys Leu Val Asp Ala Leu Glu Asp Ser Asp

215 220 225gat gtg caa aac gtc tac acc aac atc gac ttg agc gat gag gtt ttg 835Asp Val Gln Asn Val Tyr Thr Asn Ile Asp Leu Ser Asp Glu Val Leu230 235 240 245aca gag ctg gaa aac gac tagttcgtat tttccgcact ccg 876Thr Glu Leu Glu Asn Asp

250<210>404<211>251<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>404Met Ser Gly His Ser Lys Trp Ala Thr Thr Lys His Lys Lys Ala Ala 151015 Asn Asp Ala Lys Arg Gly Lys Glu Phe Ala Lys Leu Ile Lys Asn Ile

20 25 30Glu Val Ala Ala Arg Thr Gly Gly Gly Asp Pro Ser Ala Asn Pro Thr

3540 45Leu Asp Asp Met Ile Lys Lys Ala Lys Lys Ala Ser Val Pro Asn Asp

50 55 60Asn Ile Glu Arg Ala Arg Lys Arg Gly Ser Gly Glu Glu Ala Gly Gly 65 70 75 80Ala Asp Trp Met Asn Ile Met Tyr Glu Gly Tyr Gly Pro Asn Gly Val

85 90 95Ala Met Leu Ile Glu Cys Leu Thr Asp Asn Arg Asn Arg Ala Ala Thr

100 105 110Glu Val Arg Thr Ala Met Thr Lys Asn Gly Gly Asn Leu Gly Glu Ser

115 120 125Gly Ser Val Ser Tyr Met Phe Thr Arg Thr Gly Val Val Thr Val Gln

130 135 140Lys Gly Asp Leu Ser Glu Asp Asp Val Leu Met Ala Val Leu Glu Ala145 150 155 160Gly Ala Glu Glu Val Asn Asp Asn Gly Asp Leu Phe Glu Val Thr Cys

165 170 175Ala Pro Thr Asp Ile Gln Ala Val Arg Asp Ala Leu Val Glu Ala Gly

180 185 190Ile Glu Val Glu Asp Ser Glu Ser Asp Phe Arg Ala Ser Val Gln Val

195 200 205Pro Leu Asp Ala Asp Gly Ala Arg Lys Ile Phe Lys Leu Val Asp Ala

210 215 220Leu Glu Asp Ser Asp Asp Val Gln Asn Val Tyr Thr Asn Ile Asp Leu225 230 235 240Ser Asp Glu Val Leu Thr Glu Leu Glu Asn Asp

245250<210>405<211>547<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (547)<223>RXC01096<400>405accgtgaaac aaaccggcgg tgcgtgccac actggtgccc acacatgttt cgacaatgac 60gttttgctgt aaaagcaaca acgattaagg aagaaatctt atg aag cca cgc gtg 115

Met Lys Pro Arg Val

1 5ctg tca gca tta ggc att gga gct ggc gcc ctg gtt gtc tgg atc agc 163Leu Ser Ala Leu Gly Ile Gly Ala Gly Ala Leu Val Val Trp Ile Ser

10 15 20tca cgc atg aac tgg gta acc atc gag gct ttc gac gat aaa tca ggt 211Ser Arg Met Asn Trp Val Thr Ile Glu Ala Phe Asp Asp Lys Ser Gly

25 30 35agt gtc acc caa tct att gtg ggt gca acc tgg tct aca gaa atc atg 259Ser Val Thr Gln Ser Ile Val Gly Ala Thr Trp Ser Thr Glu Ile Met

40 45 50gcg ctt gca ctt gct ttg ctc gct gcc ttc gcc gcc gcg ttg gtg ctc 307Ala Leu Ala Leu Ala Leu Leu Ala Ala Phe Ala Ala Ala Leu Val Leu

55 60 65aag cgc atg ggt egg cgc atc att ggt ggt att tcg gcg ctg atc gcg 355Lys Arg Met Gly Arg Arg Ile Ile Gly Gly Ile Ser Ala Leu Ile Ala 70 75 80 85gtg ggt gcc agc ctg tct cca ctc gcg ctt ctc acc caa gac cca gac 403Val Gly Ala Ser Leu Ser Pro Leu Ala Leu Leu Thr Gln Asp Pro Asp

90 95 100gca gaa cgg gcc cga acc ctg ctg acc tcc ggt gtg gcc tca cag aag 451Ala Glu Arg Ala Arg Thr Leu Leu Thr Ser Gly Val Ala Ser Gln Lys

105 110 115gct aat tcc gga acc ctg ctg tct gat tgg gcg gag atc atc aat acc 499Ala Asn Ser Gly Thr Leu Leu Ser Asp Trp Ala Glu Ile Ile Asn Thr

120125 130acc acc cat cca ctg gcg gca gtg gta gcc atg att ggc tgc gcg cta 547Thr Thr His Pro Leu Ala Ala Val Val Ala Met Ile Gly Cys Ala Leu

135140145<210>406<211>149<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>406Met Lys Pro Arg Val Leu Ser Ala Leu Gly Ile Gly Ala Gly Ala Leu 151015 Val Val Trp Ile Ser Ser Arg Met Asn Trp Val Thr Ile Glu Ala Phe

20 25 30Asp Asp Lys Ser Gly Ser Val Thr Gln Ser Ile Val Gly Ala Thr Trp

35 40 45Ser Thr Glu Ile Met Ala Leu Ala Leu Ala Leu Leu Ala Ala Phe Ala

50 55 60Ala Ala Leu Val Leu Lys Arg Met Gly Arg Arg Ile Ile Gly Gly Ile 65 70 75 80Ser Ala Leu Ile Ala Val Gly Ala Ser Leu Ser Pro Leu Ala Leu Leu

85 90 95Thr Gln Asp Pro Asp Ala Glu Arg Ala Arg Thr Leu Leu Thr Ser Gly

100 105 110Val Ala Ser Gln Lys Ala Asn Ser Gly Thr Leu Leu Ser Asp Trp Ala

115 120 125Glu Ile Ile Asn Thr Thr Thr His Pro Leu Ala Ala Val Val Ala Met

130135140 Ile Gly Cys Ala Leu145<210>407<211>1020<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (997)<223>RXC01656<400>407tcggcaagca tggcttcatc gtcctcaaaa aagtggtcta atgcaagtga ctgaaagtgg 60atctaccgct agtccacttt gtggcgttgg atcatctgtc atg acc gaa act caa 115

Met Thr Glu Thr Gln

1 5gaa act tac caa gca acc act cgt gtg aag cgc ggc ctt gcc gac atg 163Glu Thr Tyr Gln Ala Thr Thr Arg Val Lys Arg Gly Leu Ala Asp Met

10 15 20ctc aag ggt ggt gtg atc atg gat gtg gtc acc cct gaa caa gcg cgc 211Leu Lys Gly Gly Val Ile Met Asp Val Val Thr Pro Glu Gln Ala Arg

25 30 35atc gcc gaa gat gca ggt gcc agc gca gtt atg gca ctc gag cgc gtt 259Ile Ala Glu Asp Ala Gly Ala Ser Ala Val Met Ala Leu Glu Arg Val

40 45 50ccc gcc gat atc cgt tct cag ggc ggc gtt gct cgc atg agt gat cct 307Pro Ala Asp Ile Arg Ser Gln Gly Gly Val Ala Arg Met Ser Asp Pro

55 60 65gac ctg atc gaa gga atc gtc aat gcg gtc tcc atc ccg gtc atg gcg 355Asp Leu Ile Glu Gly Ile Val Asn Ala Val Ser Ile Pro Val Met Ala 70 75 80 85aaa gct cgc atc ggt cac ttc gtg gaa gct cag gtt ctg gaa gct ctc 403Lys Ala Arg Ile Gly His Phe Val Glu Ala Gln Val Leu Glu Ala Leu

90 95 100ggt gtt gat ttc atc gac gag tcc gaa gtt ctc agc cct gcc gac tac 451Gly Val Asp Phe Ile Asp Glu Ser Glu Val Leu Ser Pro Ala Asp Tyr

105 110 115acg cac cac atc aac aag tgg aag ttc gac gtt cct ttc gtc tgt ggc 499Thr His His Ile Asn Lys Trp Lys Phe Asp Val Pro Phe Val Cys Gly

120 125 130gcg acc aac ctc ggc gaa gct ttg cga cgc atc acc gaa ggc gct gca 547Ala Thr Asn Leu Gly Glu Ala Leu Arg Arg Ile Thr Glu Gly Ala Ala

135 140 145atg atc cgt tcc aag ggc gaa gcc ggc acc ggcgat gtc tct gaa gct 595Met Ile Arg Ser Lys Gly Glu Ala Gly Thr Gly Asp Val Ser Glu Ala150 155 160 165gtc cgt cac ctg cgc acc atc cgc ggc gac atc aat cgc ctg cgc tcc 643Val Arg His Leu Arg Thr Ile Arg Gly Asp Ile Asn Arg Leu Arg Ser

170 175 180ctg gat gag gat gaa ctc ttc gtc gcc gcc aag gaa ttc cag gca cca 691Leu Asp Glu Asp Glu Leu Phe Val Ala Ala Lys Glu Phe Gln Ala Pro

185 190 195tac gac ctg gtc cgc gaa gtc gcc tcc acc ggc aag ctc cct gtg gtc 739Tyr Asp Leu Val Arg Glu Val Ala Ser Thr Gly Lys Leu Pro Val Val

200 205 210acc ttc gtt gca ggt ggc gtc gca acc cca gcc gac gct gca ctc gtg 787Thr Phe Val Ala Gly Gly Val Ala Thr Pro Ala Asp Ala Ala Leu Val

215 220 225cgc caa atg ggc gcc gaa ggc gtc ttt gtc ggc tcc ggc atc ttc aaa 835Arg Gln Met Gly Ala Glu Gly Val Phe Val Gly Ser Gly Ile Phe Lys230 235 240 245tcc ggc aat cca gcc gcc cgc gcc gca gcg atc gtc aag gct gca acg 883Ser Gly Asn Pro Ala Ala Arg Ala Ala Ala Ile Val Lys Ala Ala Thr

250 255 260ctt ttc gac gac ccc tcc gtc att gcc gac gta tcc cgc ggc ctg ggt 931Leu Phe Asp Asp Pro Ser Val Ile Ala Asp Val Ser Arg Gly Leu Gly

265 270 275gaa gcc atg gtg ggc atc aac gta tcc gac gtt cca gca cca cac cga 979Glu Ala Met Val Gly Ile Asn Val Ser Asp Val Pro Ala Pro His Arg

280 285 290ctc gcc gag cgc ggc tgg tgatcgttgg agttttagct ctc 1020Leu Ala Glu Arg Gly Trp

295<210>408<211>299<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>408Met Thr Glu Thr Gln Glu Thr Tyr Gln Ala Thr Thr Arg Val Lys Arg 151015 Gly Leu Ala Asp Met Leu Lys Gly Gly Val Ile Met Asp Val Val Thr

20 25 30Pro Glu Gln Ala Arg Ile Ala Glu Asp Ala Gly Ala Ser Ala Val Met

35 40 45Ala Leu Glu Arg Val Pro Ala Asp Ile Arg Ser Gln Gly Gly Val Ala

50 55 60Arg Met Ser Asp Pro Asp Leu Ile Glu Gly Ile Val Asn Ala Val Ser 65 70 75 80Ile Pro Val Met Ala Lys Ala Arg Ile Gly His Phe Val Glu Ala Gln

85 90 95Val Leu Glu Ala Leu Gly Val Asp Phe Ile Asp Glu Ser Glu Val Leu

100 105 110Ser Pro Ala Asp Tyr Thr His His Ile Asn Lys Trp Lys Phe Asp Val

115 120 125Pro Phe Val Cys Gly Ala Thr Asn Leu Gly Glu Ala Leu Arg Arg Ile

130 135 140Thr Glu Gly Ala Ala Met Ile Arg Ser Lys Gly Glu Ala Gly Thr Gly145 150 155 160Asp Val Ser Glu Ala Val Arg His Leu Arg Thr Ile Arg Gly Asp Ile

165 170 175Asn Arg Leu Arg Ser Leu Asp Glu Asp Glu Leu Phe Val Ala Ala Lys

180 185 190Glu Phe Gln Ala Pro Tyr Asp Leu Val Arg Glu Val Ala Ser Thr Gly

195 200 205Lys Leu Pro Val Val Thr Phe Val Ala Gly Gly Val Ala Thr Pro Ala

210215 220Asp Ala Ala Leu Val Arg Gln Met Gly Ala Glu Gly Val Phe Val Gly225 230 235 240Ser Gly Ile Phe Lys Ser Gly Asn Pro Ala Ala Arg Ala Ala Ala Ile

245 250 255Val Lys Ala Ala Thr Leu Phe Asp Asp Pro Ser Val Ile Ala Asp Val

260 265 270Ser Arg Gly Leu Gly Glu Ala Met Val Gly Ile Asn Val Ser Asp Val

275 280 285Pro Ala Pro His Arg Leu Ala Glu Arg Gly Trp

290295<210>409<211>1065<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1042)<223>RXC01158<400>409taggacgttc aaggaattgg ctgaatcaac aagcgccaag gtggttaagc gccctcggcg 60agttatctca aaaaagaaga agaagtctcc tacgggagag atg tcc att gtt gag 115

Met Ser Ile Val Glu

1 5cac atc aaa gag ttt cga cgc cga ctt ctt atc get ctg gcg ggc atc 163His Ile Lys Glu Phe Arg Arg Arg Leu Leu Ile Ala Leu Ala Gly Ile

10 15 20ctc gtg ggc acc att atc ggc ttt att tgg tac gat ttc tca ttt tgg 211Leu Val Gly Thr Ile Ile Gly Phe Ile Trp Tyr Asp Phe Ser Phe Trp

25 30 35cag atc ccc act ttg ggc gag ctg ctg agg gat ccg tac tgt tct ctg 259Gln Ile Pro Thr Leu Gly Glu Leu Leu Arg Asp Pro Tyr Cys Ser Leu

40 45 50cct gct gaa tcc cgc tgg gcc atg agc gac tca gag gaa tgt cga ctg 307Pro Ala Glu Ser Arg Trp Ala Met Ser Asp Ser Glu Glu Cys Arg Leu

55 60 65ctc gca acc ggc ccg ttt gat cca ttc atg ctt cgc ctt aaa gta gcg 355Leu Ala Thr Gly Pro Phe Asp Pro Phe Met Leu Arg Leu Lys Val Ala 70 75 80 85gcg ttg gtg ggt atg gtt ctt ggc tca ccc gtg tgg ctg agc cag ctg 403Ala Leu Val Gly Met Val Leu Gly Ser Pro Val Trp Leu Ser Gln Leu

90 95 100tgg ggc ttt atc acc cca ggt ttg atg aag aat gag cgc cgt tac acc 451Trp Gly Phe Ile Thr Pro Gly Leu Met Lys Asn Glu Arg Arg Tyr Thr

105 110 115gca atc ttc gtc acg att gct gtt gtg ctg ttt gtc ggc ggt gct gtt 499Ala Ile Phe Val Thr Ile Ala Val Val Leu Phe Val Gly Gly Ala Val

120 125 130ctt gcg tac ttc gtc gtt gca tat ggt ttg gag ttc ctc ctt acc att 547Leu Ala Tyr Phe Val Val Ala Tyr Gly Leu Glu Phe Leu Leu Thr Ile

135 140 145ggt gga gac acc cag gca gcg gcc ctg act ggt gat aag tacttc gga 595Gly Gly Asp Thr Gln Ala Ala Ala Leu Thr Gly Asp Lys Tyr Phe Gly150 155 160 165ttc ttg ctc gcg ttg ttg gcg att ttc ggc gtg agc ttc gaa gtt cca 643Phe Leu Leu Ala Leu Leu Ala Ile Phe Gly Val Ser Phe Glu Val Pro

170 175 180ctg gtg atc ggc atg ctc aac att gtg ggt atc ttg cct tac gat gcc 691Leu Val Ile Gly Met Leu Asn Ile Val Gly Ile Leu Pro Tyr Asp Ala

185 190 195att aaa gat aag cga cgc atg atc atc atg att ttg ttc gtg ttc gct 739Ile Lys Asp Lys Arg Arg Met Ile Ile Met Ile Leu Phe Val Phe Ala

200 205 210gct ttc atg aca ccc ggc cag gat cct ttcacc atg ttg gtg ttg gcg 787Ala Phe Met Thr Pro Gly Gln Asp Pro Phe Thr Met Leu Val Leu Ala

215 220 225ctt tca ctc acc gtt ctg gta gag ctt gcc ctg cag ttc tgt cgc ttc 835Leu Ser Leu Thr Val Leu Val Glu Leu Ala Leu Gln Phe Cys Arg Phe230 235 240 245aac gac aaa cgc cgg gac aag aag cgc cca gaa tgg ctt gat ggc gat 883Asn Asp Lys Arg Arg Asp Lys Lys Arg Pro Glu Trp Leu Asp Gly Asp

250 255 260gac ctc tct gca tca cca ctg gat act tct gct ggt gga gaa gat gct 931Asp Leu Ser Ala Ser Pro Leu Asp Thr Ser Ala Gly Gly Glu Asp Ala

265 270 275cca agc cca gtc gaa acc cca gag gcg gtg gag cct tcg cgg atg ctg 979Pro Ser Pro Val Glu Thr Pro Glu Ala Val Glu Pro Ser Arg Met Leu

280 285 290aac cca agt ggg gag gcg tcg ata agc tat aaa ccc ggg cgc gcc gac 1027Asn Pro Ser Gly Glu Ala Ser Ile Ser Tyr Lys Pro Gly Arg Ala Asp

295300305 ttc ggt gac gtg ctc tagggcctag ccaggtaccc tta 1065Phe Gly Asp Val Leu310<210>410<211>314<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>410Met Ser Ile Val Glu His Ile Lys Glu Phe Arg Arg Arg Leu Leu Ile 151015 Ala Leu Ala Gly Ile Leu Val Gly Thr Ile Ile Gly Phe Ile Trp Tyr

20 25 30Asp Phe Ser Phe Trp Gln Ile Pro Thr Leu Gly Glu Leu Leu Arg Asp

35 40 45Pro Tyr Cys Ser Leu Pro Ala Glu Ser Arg Trp Ala Met Ser Asp Ser

50 55 60Glu Glu Cys Arg Leu Leu Ala Thr Gly Pro Phe Asp Pro Phe Met Leu 65 70 7580Arg Leu Lys Val Ala Ala Leu Val Gly Met Val Leu Gly Ser Pro Val

85 90 95Trp Leu Ser Gln Leu Trp Gly Phe Ile Thr Pro Gly Leu Met Lys Asn

100 105 110Glu Arg Arg Tyr Thr Ala Ile Phe Val Thr Ile Ala Val Val Leu Phe

115 120 125Val Gly Gly Ala Val Leu Ala Tyr Phe Val Val Ala Tyr Gly Leu Glu

130 135 140Phe Leu Leu Thr Ile Gly Gly Asp Thr Gln Ala Ala Ala Leu Thr Gly145 150 155 160Asp Lys Tyr Phe Gly Phe Leu Leu Ala Leu Leu Ala Ile Phe Gly Val

165 170 175Ser Phe Glu Val Pro Leu Val Ile Gly Met Leu Asn Ile Val Gly Ile

180 185 190Leu Pro Tyr Asp Ala Ile Lys Asp Lys Arg Arg Met Ile Ile Met Ile

195 200 205Leu Phe Val Phe Ala Ala Phe Met Thr Pro Gly Gln Asp Pro Phe Thr

210 215 220Met Leu Val Leu Ala Leu Ser Leu Thr Val Leu Val Glu Leu Ala Leu225 230 235 240Gln Phe Cys Arg Phe Asn Asp Lys Arg Arg Asp Lys Lys Arg Pro Glu

245 250 255Trp Leu Asp Gly Asp Asp Leu Ser Ala Ser Pro Leu Asp Thr Ser Ala

260 265 270Gly Gly Glu Asp Ala Pro Ser Pro Val Glu Thr Pro Glu Ala Val Glu

275 280 285Pro Ser Arg Met Leu Asn Pro Ser Gly Glu Ala Ser Ile Ser Tyr Lys

290295300 Pro Gly Arg Ala Asp Phe Gly Asp Val Leu 305310<210>411<211>1413<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) · (1390)<223>RXA02458<400>411ttgcggagcc acgactgatc ggtcaagtgc tatctcggtt gcatcaataa gcgaatcacc 60ggtggtgaac aaaacaaatc ttccacacat aacatctatt atg gtc ttt gtg tct 115

Met Val Phe Val Ser

1 5gat tcg tct atc tct ttg ccc att tgg gat gct ccg cgc gct cgc ggc 163Asp Ser Ser Ile Ser Leu Pro Ile Trp Asp Ala Pro Arg Ala Arg Gly

10 15 20ccc ata gtc tcg gac ctg gct atc cct ggt tcc aag tcg atc acc aac 211Pro Ile Val Ser Asp Leu Ala Ile Pro Gly Ser Lys Ser Ile Thr Asn

25 30 35cgc gcc ctc atc ttg gct gcg ctc gca tca act cca tcc acc atc att 259Arg Ala Leu Ile Leu Ala Ala Leu Ala Ser Thr Pro Ser Thr Ile Ile

40 45 50gat gtc ctt cgt agt cgt gat acc gat ctc atg act gat ggt cta cgc 307Asp Val Leu Arg Ser Arg Asp Thr Asp Leu Met Thr Asp Gly Leu Arg

55 60 65agc ctc gga atc acc att act gaa gag gca gtc gat cgc tac cgc gtt 355Ser Leu Gly Ile Thr Ile Thr Glu Glu Ala Val Asp Arg Tyr Arg Val 70 75 80 85gag ccc gga cag ttg tct gct ggc tcc gtt gag tgt ggt ctt gct ggt 403Glu Pro Gly Gln Leu Ser Ala Gly Ser Val Glu Cys Gly Leu Ala Gly

90 95 100acg gtc atg cgc ttt ttg cct cct gtt gct gct ttc gct gat ggt cct 451Thr Val Met Arg Phe Leu Pro Pro Val Ala Ala Phe Ala Asp Gly Pro

105110 115gtt cat ttt gat ggc gat cct caa gct cgt gtt cgt ccg atg acc agc 499Val His Phe Asp Gly Asp Pro Gln Ala Arg Val Arg Pro Met Thr Ser

120 125 130att ttg gat gcg ctg cgt tcg ctt ggt gtg gag gta gac aac aac aat 547Ile Leu Asp Ala Leu Arg Ser Leu Gly Val Glu Val Asp Asn Asn Asn

135 140 145ctg cct ttc act gtt aat gct ggt gag gtc cct gag ggt ggc gtg gtt 595Leu Pro Phe Thr Val Asn Ala Gly Glu Val Pro Glu Gly Gly Val Val150 155 160 165gag att gat gct tcc ggc tca tct cag ttt gtt tct ggt ctt ttg ctt 643Glu Ile Asp Ala Ser Gly Ser Ser Gln Phe Val Ser Gly Leu Leu Leu

170 175 180tca gcg cct cgt ttt aaa aat ggc gtc acc gtt aag cac gtc ggt ggt 691Ser Ala Pro Arg Phe Lys Asn Gly Val Thr Val Lys His Val Gly Gly

185 190 195cgt ctg ccg agc atg ccg cat att gag atg acc gtc gat atg ctt cgt 739Arg Leu Pro Ser Met Pro His Ile Glu Met Thr Val Asp Met Leu Arg

200 205 210tcc gca ggc att gag atc gaa gag tca gaa aat cag tgg gtt gtt cat 787Ser Ala Gly Ile Glu Ile Glu Glu Ser Glu Asn Gln Trp Val Val His

215 220 225cct ggt gag atc ttg ggt cgg acc tgg cgc att gag ccg gat ctt tct 835Pro Gly Glu Ile Leu Gly Arg Thr Trp Arg Ile Glu Pro Asp Leu Ser230 235 240 245aat gcg act ccg ttc cta gct gcc gct gcg gtc act ggt gga acc atc 883Asn Ala Thr Pro Phe Leu Ala Ala Ala Ala Val Thr Gly Gly Thr Ile

250 255 260aag att aac cac tgg cca atc aaa act act cag cct ggc gat gct att 931Lys Ile Asn His Trp Pro Ile Lys Thr Thr Gln Pro Gly Asp Ala Ile

265 270 275cgt tcg att ctt gag cgc atg ggc tgc gaa gtt gag ctg gtt gct cag 979Arg Ser Ile Leu Glu Arg Met Gly Cys Glu Val Glu Leu Val Ala Gln

280 285 290ggt gaa ggt tac gat ctg tcg gtg act ggt ccg gtt gct ctc aag ggc 1027Gly Glu Gly Tyr Asp Leu Ser Val Thr Gly Pro Val Ala Leu Lys Gly

295 300 305att gag atc gat atg tcc gat atc ggt gag ttg acc cct acc gtg gcg 1075Ile Glu Ile Asp Met Ser Asp Ile Gly Glu Leu Thr Pro Thr Val Ala310 315 320 325gcg ttg gct gcg ttg gcg tcg aca gag tct cgt ttg acc ggt att gct 1123Ala Leu Ala Ala Leu Ala Ser Thr Glu Ser Arg Leu Thr Gly Ile Ala

330 335 340cat ctt cgt ggc cat gag acg gat cgt ttg gct gcg ttg act gcg gag 1171His Leu Arg Gly His Glu Thr Asp Arg Leu Ala Ala Leu Thr Ala Glu

345 350 355atc aac aaa ctt ggt gga aag tgc act gag ctt aag gat ggt ctg ttg 1219Ile Asn Lys Leu Gly Gly Lys Cys Thr Glu Leu Lys Asp Gly Leu Leu

360 365 370att gag cct gcg tcg ctg cac ggt ggt gtg tgg cat tca tat gct gat 1267Ile Glu Pro Ala Ser Leu His Gly Gly Val Trp His Ser Tyr Ala Asp

375 380 385cac cgt atg gct act gct ggt gcg atc att ggc ctc gcg gtt gat ggc 1315His Arg Met Ala Thr Ala Gly Ala Ile Ile Gly Leu Ala Val Asp Gly390 395 400 405gtt cag gtt gaa gac att aag acc act tcc aaa act ttc cct ggt ttt 1363Val Gln Val Glu Asp Ile Lys Thr Thr Ser Lys Thr Phe Pro Gly Phe

410415 420gaa aat gtt tgg gag gag atg gtt ggc tagacgcagc tatgacgaat 1410Glu Asn Val Trp Glu Glu Met Val Gly

425430 ccg 1413<210>412<211>430<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>412Met Val Phe Val Ser Asp Ser Ser Ile Ser Leu Pro Ile Trp Asp Ala l 51015 Pro Arg Ala Arg Gly Pro Ile Val Ser Asp Leu Ala Ile Pro Gly Ser

20 25 30Lys Ser Ile Thr Asn Arg Ala Leu Ile Leu Ala Ala Leu Ala Ser Thr

35 40 45Pro Ser Thr Ile Ile Asp Val Leu Arg Ser Arg Asp Thr Asp Leu Met

50 55 60Thr Asp Gly Leu Arg Ser Leu Gly Ile Thr Ile Thr Glu Glu Ala Val 65 70 75 80Asp Arg Tyr Arg Val Glu Pro Gly Gln Leu Ser Ala Gly Ser Val Glu

85 90 95Cys Gly Leu Ala Gly Thr Val Met Arg Phe Leu Pro Pro Val Ala Ala

100 105 110Phe Ala Asp Gly Pro Val His Phe Asp Gly Asp Pro Gln Ala Arg Val

115 120 125Arg Pro Met Thr Ser Ile Leu Asp Ala Leu Arg Ser Leu Gly Val Glu

130 135 140Val Asp Asn Asn Asn Leu Pro Phe Thr Val Asn Ala Gly Glu Val Pro145 150 155 160Glu Gly Gly Val Val Glu Ile Asp Ala Ser Gly Ser Ser Gln Phe Val

165 170 175Ser Gly Leu Leu Leu Ser Ala Pro Arg Phe Lys Asn Gly Val Thr Val

180 185 190Lys His Val Gly Gly Arg Leu Pro Ser Met Pro His Ile Glu Met Thr

195 200 205Val Asp Met Leu Arg Ser Ala Gly Ile Glu Ile Glu Glu Ser Glu Asn

210 215 220Gln Trp Val Val His Pro Gly Glu Ile Leu Gly Arg Thr Trp Arg Ile225 230 235 240Glu Pro Asp Leu Ser Asn Ala Thr Pro Phe Leu Ala Ala Ala Ala Val

245 250 255Thr Gly Gly Thr Ile Lys Ile Asn His Trp Pro Ile Lys Thr Thr Gln

260 265 270Pro Gly Asp Ala Ile Arg Ser Ile Leu Glu Arg Met Gly Cys Glu Val

275 280 285Glu Leu Val Ala Gln Gly Glu Gly Tyr Asp Leu Ser Val Thr Gly Pro

290 295 300Val Ala Leu Lys Gly Ile Glu Ile Asp Met Ser Asp Ile Gly Glu Leu305 310 315 320Thr Pro Thr Val Ala Ala Leu Ala Ala Leu Ala Ser Thr Glu Ser Arg

325 330 335Leu Thr Gly Ile Ala His Leu Arg Gly His Glu Thr Asp Arg Leu Ala

340 345 350Ala Leu Thr Ala Glu Ile Asn Lys Leu Gly Gly Lys Cys Thr Glu Leu

355 360 365Lys Asp Gly Leu Leu Ile Glu Pro Ala Ser Leu His Gly Gly Val Trp

370 375 380His Ser Tyr Ala Asp His Arg Met Ala Thr Ala Gly Ala Ile Ile Gly385 390 395 400Leu Ala Val Asp Gly Val Gln Val Glu Asp Ile Lys Thr Thr Ser Lys

405 410 415Thr Phe Pro Gly Phe Glu Asn Val Trp Glu Glu Met Val Gly

420425430<210>413<211>1266<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1243)<223>RXA02790<400>413tggatgctcg cacccgagcc cttgaaccac aatccacaga cacccaagat ttcgacgaga 60agggaaattt cccaggatga accaaatccg aaaccgccgg atg gag ccc gtc tac 115

Met Glu Pro Val Tyr

1 5gta aag cgc cgc caa cgg ttt att gcc gtg acg atc gct tca ctc atc 163Val Lys Arg Arg Gln Arg Phe Ile Ala Val Thr Ile Ala Ser Leu Ile

10 15 20ctc att atc ggt gcc atc atc tat atc ggt gta gcc acc tca aac cgg 211Leu Ile Ile Gly Ala Ile Ile Tyr Ile Gly Val Ala Thr Ser Asn Arg

25 30 35acg cca cat gac tat gaa ggc tcc gga aac ggt gtg gtt cag ctg gtc 259Thr Pro His Asp Tyr Glu Gly Ser Gly Asn Gly Val Val Gln Leu Val

40 45 50gaa atc cct gaa ggt tcc tcc ata tca gag ctc ggc cca gag ttg gaa 307Glu Ile Pro Glu Gly Ser Ser Ile Ser Glu Leu Gly Pro Glu Leu Glu

55 60 65gaa cga gat atc gtg gcc acc aac tca gcg ttc caa aca gcg gcc agc 355Glu Arg Asp Ile Val Ala Thr Asn Ser Ala Phe Gln Thr Ala Ala Ser 70 75 80 85aac aac ccc aac gcg ggt agt gta cag cca ggt ttc tac cgt ctg cag 403Asn Asn Pro Asn Ala Gly Ser Val Gln Pro Gly Phe Tyr Arg Leu Gln

90 95 100gaa caa atg aac gca gca gct gca gtg tcg gct ctg ctt gat cca gac 451Glu Gln Met Asn Ala Ala Ala Ala Val Ser Ala Leu Leu Asp Pro Asp

105 110 115aac cag gtt gat ctc ctc gac att cac ggc ggc gcc acc ttg atg gac 499Asn Gln Val Asp Leu Leu Asp Ile His Gly Gly Ala Thr Leu Met Asp

120 125 130gtc act gtt gtc ggc gga aac acc cgc gcg gga atc tac tcc cag atc 547Val Thr Val Val Gly Gly Asn Thr Arg Ala Gly Ile Tyr Ser Gln Ile

135 140 145gca gcc gtg acc tgc acc gaa ggc tcc gcc aac tgc atc acc gct gag 595Ala Ala Val Thr Cys Thr Glu Gly Ser Ala Asn Cys Ile Thr Ala Glu150 155 160 165gat ttg cag cag gtt gcc tcc acc gtg tcg cct gca gaa ttg ggt gtc 643Asp Leu Gln Gln Val Ala Ser Thr Val Ser Pro Ala Glu Leu Gly Val

170 175 180cca gat tgg gca atc gct gct gtg gaa gct cgc gga act gat cca aag 691Pro Asp Trp Ala Ile Ala Ala Val Glu Ala Arg Gly Thr Asp Pro Lys

185 190 195cgc ctc gaa ggc ctg atc atg cct ggc caa tac gtg gtg gat cca tcc 739Arg Leu Glu Gly Leu Ile Met Pro Gly Gln Tyr Val Val Asp Pro Ser

200 205 210aac gac gcc cag gga atc ctc acc gat ctg atc acg cga tca gca aac 787Asn Asp Ala Gln Gly Ile Leu Thr Asp Leu Ile Thr Arg Ser Ala Asn

215 220 225cat ttc caa gaa acc gac atc acg ggc cgt gca gat gcc atc gga ctt 835His Phe Gln Glu Thr Asp Ile Thr Gly Arg Ala Asp Ala Ile Gly Leu230 235 240 245act cca tat gag ctg gtc acc gca gca tct tta atc gag cgc gaa gca 883Thr Pro Tyr Glu Leu Val Thr Ala Ala Ser Leu Ile Glu Arg Glu Ala

250 255 260cca gca gga gat ttt gat aag gtc gcc cgc gtc atc ttg aac cgt ctc931Pro Ala Gly Asp Phe Asp Lys Val Ala Arg Val Ile Leu Asn Arg Leu

265 270 275gcc gag cca atg cag ctg caa ttc gac tcc acc gtc aac tac ggt ctg 979Ala Glu Pro Met Gln Leu Gln Phe Asp Ser Thr Val Asn Tyr Gly Leu

280 285 290tct gaa caa gaa gta gca acc acc gac gaa gac cgt cag acc gtc acc 1027Ser Glu Gln Glu Val Ala Thr Thr Asp Glu Asp Arg Gln Thr Val Thr

295 300 305cca tgg aac act tac gcc atg gac ggc ctg cca caa acc ccc atc gcc 1075Pro Trp Asn Thr Tyr Ala Met Asp Gly Leu Pro Gln Thr Pro Ile Ala310 315 320 325gca gta tcc acc gaa gca ctc caa gcc atg gaa aac cct gca gaa gga 1123Ala Val Ser Thr Glu Ala Leu Gln Ala Met Glu Asn Pro Ala Glu Gly

330 335 340aac tgg ctg tac ttt gtc acc atc gac acc gat gga acc acc gtg ttc 1171Asn Trp Leu Tyr Phe Val Thr Ile Asp Thr Asp Gly Thr Thr Val Phe

345 350 355aac gac acc ttc gaa gag cac gaa gcc gac att gag caa gct ttg aac 1219Asn Asp Thr Phe Glu Glu His Glu Ala Asp Ile Glu Gln Ala Leu Asn

360 365 370agt ggc gtt cta gac agc aac cga taaggatcag cgaataaaat tgg 1266Ser Gly Val Leu Asp Ser Asn Arg

375380<210>414<211>381<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>414Met Glu Pro Val Tyr Val Lys Arg Arg Gln Arg Phe Ile Ala Val Thr 151015 Ile Ala Ser Leu Ile Leu Ile Ile Gly Ala Ile Ile Tyr Ile Gly Val

20 25 30Ala Thr Ser Asn Arg Thr Pro His Asp Tyr Glu Gly Ser Gly Asn Gly

35 40 45Val Val Gln Leu Val Glu Ile Pro Glu Gly Ser Ser Ile Ser Glu Leu

50 55 60Gly Pro Glu Leu Glu Glu Arg Asp Ile Val Ala Thr Asn Ser Ala Phe 65 70 75 80Gln Thr Ala Ala Ser Asn Asn Pro Asn Ala Gly Ser Val Gln Pro Gly

85 90 95Phe Tyr Arg Leu Gln Glu Gln Met Asn Ala Ala Ala Ala Val Ser Ala

100 105 110Leu Leu Asp Pro Asp Asn Gln Val Asp Leu Leu Asp Ile His Gly Gly

115 120 125Ala Thr Leu Met Asp Val Thr Val ValGly Gly Asn Thr Arg Ala Gly

130 135 140Ile Tyr Ser Gln Ile Ala Ala Val Thr Cys Thr Glu Gly Ser Ala Asn145 150 155 160Cys Ile Thr Ala Glu Asp Leu Gln Gln Val Ala Ser Thr Val Ser Pro

165 170 175Ala Glu Leu Gly Val Pro Asp Trp Ala Ile Ala Ala Val Glu Ala Arg

180 185 190Gly Thr Asp Pro Lys Arg Leu Glu Gly Leu Ile Met Pro Gly Gln Tyr

195 200 205Val Val Asp Pro Ser Asn Asp Ala Gln Gly Ile Leu Thr Asp Leu Ile

210 215 220Thr Arg Ser Ala Asn His Phe Gln Glu Thr Asp Ile Thr Gly Arg Ala225 230 235 240Asp Ala Ile Gly Leu Thr Pro Tyr Glu Leu Val Thr Ala Ala Ser Leu

245 250 255Ile Glu Arg Glu Ala Pro Ala Gly Asp Phe Asp Lys Val Ala Arg Val

260265 270Ile Leu Asn Arg Leu Ala Glu Pro Met Gln Leu Gln Phe Asp Ser Thr

275 280 285Val Asn Tyr Gly Leu Ser Glu Gln Glu Val Ala Thr Thr Asp Glu Asp

290 295 300Arg Gln Thr Val Thr Pro Trp Asn Thr Tyr Ala Met Asp Gly Leu Pro305 310 315 320Gln Thr Pro Ile Ala Ala Val Ser Thr Glu Ala Leu Gln Ala Met Glu

325 330 335Asn Pro Ala Glu Gly Asn Trp Leu Tyr Phe Val Thr Ile Asp Thr Asp

340 345 350Gly Thr Thr Val Phe Asn Asp Thr Phe Glu Glu His Glu Ala Asp Ile

355 360 365Glu Gln Ala Leu Asn Ser Gly Val Leu Asp Ser Asn Arg

370375380<210>415<211>644<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) }, (621)<223>RXN00954<400>415gct gtg aag tgg ttc gaa gcg tcc aac ttc acc ttc ctg ttc gca cct 48Ala Val Lys Trp Phe Glu Ala Ser Asn Phe Thr Phe Leu Phe Ala Pro 151015 gcg tac aac cct gcg att gcg cat gtg cag ccg gtt cgc cag gcg ctg 96Ala Tyr Asn Pro Ala Ile Ala His Val Gln Pro Val Arg Gln Ala Leu

20 25 30aaa ttc ccc acc atc ttc aac acg ctt gga cca ttg ctg tcc ccg gcg 144Lys Phe Pro Thr Ile Phe Asn Thr Leu Gly Pro Leu Leu Ser Pro Ala

35 40 45cgc ccg gag cgt cag atc atg ggc gtg gcc aat gcc aat cat gga cag 192Arg Pro Glu Arg Gln Ile Met Gly Val Ala Asn Ala Asn His Gly Gln

50 55 60ctc atc gcc gag gtc ttc cgc gag ttg ggc cgt aca cgc gcg ctt gtt 240Leu Ile Ala Glu Val Phe Arg Glu Leu Gly Arg Thr Arg Ala Leu Val 65 70 75 80gtg cat ggc gca ggc acc gat gag atc gca gtc cac ggc acc acc ttg 288Val His Gly Ala Gly Thr Asp Glu Ile Ala Val His Gly Thr Thr Leu

85 90 95gtg tgg gag ctt aaa gaa gac ggc acc atc gag cat tac acc atc gag 336Val Trp Glu Leu Lys Glu Asp Gly Thr Ile Glu His Tyr Thr Ile Glu

100 105 110cct gag gac ctt ggc ctt ggc cgc tac acc ctt gag gat ctc gta ggt 384Pro Glu Asp Leu Gly Leu Gly Arg Tyr Thr Leu Glu Asp Leu Val Gly

115 120 125ggc ctc ggc act gag aac gcc gaa gct atg cgc gct act ttc gcg ggc 432Gly Leu Gly Thr Glu Asn Ala Glu Ala Met Arg Ala Thr Phe Ala Gly

130 135 140acc ggc cct gat gca cac cgt gat gcg ttg gct gcg tcc gca ggt gcg 480Thr Gly Pro Asp Ala His Arg Asp Ala Leu Ala Ala Ser Ala Gly Ala145 150 155 160atg ttc tac ctc aac ggc gat gtc gac tcc ttg aaa gat ggt gca caa 528Met Phe Tyr Leu Asn Gly Asp Val Asp Ser Leu Lys Asp Gly Ala Gln

165 170 175aag gcg ctt tcc ttg ctt gcc gac ggc acc acc cag gca tgg ttg gcc 576Lys Ala Leu Ser Leu Leu Ala Asp Gly Thr Thr Gln Ala Trp Leu Ala

180 185 190aag cac gaa gag atc gat tac tca gaa aag gag tct tcc aat gac 621Lys His Glu Glu Ile Asp Tyr Ser Glu Lys Glu Ser Ser Asn Asp

195200205 tagtaataat ctgcccacag tgt 644<210>416<211>207<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>416Ala Val Lys Trp Phe Glu Ala Ser Asn Phe ThrPhe Leu Phe Ala Pro 151015 Ala Tyr Asn Pro Ala Ile Ala His Val Gln Pro Val Arg Gln Ala Leu

20 25 30Lys Phe Pro Thr Ile Phe Asn Thr Leu Gly Pro Leu Leu Ser Pro Ala

35 40 45Arg Pro Glu Arg Gln Ile Met Gly Val Ala Asn Ala Asn His Gly Gln

50 55 60Leu Ile Ala Glu Val Phe Arg Glu Leu Gly Arg Thr Arg Ala Leu Val 65 70 75 80Val His Gly Ala Gly Thr Asp Glu Ile Ala Val His Gly Thr Thr Leu

85 90 95Val Trp Glu Leu Lys Glu Asp Gly Thr Ile Glu His Tyr Thr Ile Glu

100 105 110Pro Glu Asp Leu Gly Leu Gly Arg Tyr Thr Leu Glu Asp Leu Val Gly

115 120 125Gly Leu Gly Thr Glu Asn Ala Glu Ala Met Arg Ala Thr Phe Ala Gly

130 135 140Thr Gly Pro Asp Ala His Arg Asp Ala Leu Ala Ala Ser Ala Gly Ala145 150 155 160Met Phe Tyr Leu Asn Gly Asp Val Asp Ser Leu Lys Asp Gly Ala Gln

165 170 175Lys Ala Leu Ser Leu Leu Ala Asp Gly Thr Thr Gln Ala Trp Leu Ala

180 185 190Lys His Glu Glu Ile Asp Tyr Ser Glu Lys Glu Ser Ser Asn Asp

195200205<210>417<211>611<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (588)<223>FRXA00954<400>417ttc ctg ttc gca cct gcg tac aac cct gcg att gcg cat gtg cag ccg 48Phe Leu Phe Ala Pro Ala Tyr AsnPro Ala Ile Ala His Val Gln Pro 151015 gtt cgc cag gcg ctg aaa ttc ccc acc atc ttc aac acg ctt gga cca 96Val Arg Gln Ala Leu Lys Phe Pro Thr Ile Phe Asn Thr Leu Gly Pro

20 25 30ttg ctg tcc ccg gcg cgc ccg gag cgt cag atc atg ggc gtg gcc aat 144Leu Leu Ser Pro Ala Arg Pro Glu Arg Gln Ile Met Gly Val Ala Asn

35 40 45gcc aat cat gga cag ctc atc gcc gag gtc ttc cgc gag ttg ggc cgt 192Ala Asn His Gly Gln Leu Ile Ala Glu Val Phe Arg Glu Leu Gly Arg

50 55 60aca cgc gcg ctt gtt gtg cat ggc gca ggc acc gat gag atc gca gtc 240Thr Arg Ala Leu Val Val His Gly Ala Gly Thr Asp Glu Ile Ala Val 65 70 75 80cac ggc acc acc ttg gtg tgg gag ctt aaa gaa gac ggc acc atc gag 288His Gly Thr Thr Leu Val Trp Glu Leu Lys Glu Asp Gly Thr Ile Glu

85 90 95cat tac acc atc gag cct gag gac ctt ggc ctt ggc cgc tac acc ctt 336His Tyr Thr Ile Glu Pro Glu Asp Leu Gly Leu Gly Arg Tyr Thr Leu

100 105 110gag gat ctc gta ggt ggc ctc ggc act gag aac gcc gaa gct atg cgc 384Glu Asp Leu Val Gly Gly Leu Gly Thr Glu Asn Ala Glu Ala Met Arg

115 120 125gct act ttc gcg ggc acc ggc cct gat gca cac cgt gat gcg ttg gct 432Ala Thr Phe Ala Gly Thr Gly Pro Asp Ala His Arg Asp Ala Leu Ala

130 135 140gcg tcc gca ggt gcg atg ttc tac ctc aac ggc gat gtc gac tcc ttg 480Ala Ser Ala Gly Ala Met Phe Tyr Leu Asn Gly Asp Val Asp Ser Leu145 150 155 160aaa gat ggt gca caa aag gcg ctt tcc ttg ctt gcc gac ggc acc acc 528Lys Asp Gly AlaGln Lys Ala Leu Ser Leu Leu Ala Asp Gly Thr Thr

165 170 175cag gca tgg ttg gcc aag cac gaa gag atc gat tac tca gaa aag gag 576Gln Ala Trp Leu Ala Lys His Glu Glu Ile Asp Tyr Ser Glu Lys Glu

180 185 190tct tcc aat gac tagtaataat ctgcccacag tgt 611Ser Ser Asn Asp

195<210>418<211>196<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>418Phe Leu Phe Ala Pro Ala Tyr Asn Pro Ala Ile Ala His Val Gln Pro 151015 Val Arg Gln Ala Leu Lys Phe Pro Thr Ile Phe Asn Thr Leu Gly Pro

20 25 30Leu Leu Ser Pro Ala Arg Pro Glu Arg Gln Ile Met Gly Val Ala Asn

35 40 45Ala Asn His Gly Gln Leu Ile Ala Glu Val Phe Arg Glu Leu Gly Arg

50 55 60Thr Arg Ala Leu Val Val His Gly Ala Gly Thr Asp Glu Ile Ala Val 65 70 75 80His Gly Thr Thr Leu Val Trp Glu Leu Lys Glu Asp Gly Thr Ile Glu

85 90 95His Tyr Thr Ile Glu Pro Glu Asp Leu Gly Leu Gly Arg Tyr Thr Leu

100 105 110Glu Asp Leu Val Gly Gly Leu Gly Thr Glu Asn Ala Glu Ala Met Arg

115 120 125Ala Thr Phe Ala Gly Thr Gly Pro Asp Ala His Arg Asp Ala Leu Ala

130 135 140Ala Ser Ala Gly Ala Met Phe Tyr Leu Asn Gly Asp Val Asp Ser Leu145 150 155 160Lys Asp Gly Ala Gln Lys Ala Leu Ser Leu Leu Ala Asp Gly Thr Thr

165 170 175Gln Ala Trp Leu Ala Lys His Glu Glu Ile Asp Tyr Ser Glu Lys Glu

180 185 190Ser Ser Asn Asp

195<210>419<211>1677<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). - (1654)<223>RXN00957<400>419aaccggcaag ccctggatcg aatgaagctc gcagcgagta attatttgat gtttcccaga 60aaggcttcag ccccacaatg atttcctcgg taggtgcccc atg agc acg aat ccc 115

Met Ser Thr Asn Pro

1 5cat gtt ttc tcc cta gat gtc cgc tat cac gag gat gct tct gca ttg 163His Val Phe Ser Leu Asp Val Arg Tyr His Glu Asp Ala Ser Ala Leu

10 15 20ttt gcc cac ttg ggt ggc aca acc gca gat gat gca gcc ctg ttg gaa 211Phe Ala His Leu Gly Gly Thr Thr Ala Asp Asp Ala Ala Leu Leu Glu

25 30 35agc gct gat atc acc acc aag aat ggt att tct tcc ctc gcg gtg ttg 259Ser Ala Asp Ile Thr Thr Lys Asn Gly Ile Ser Ser Leu Ala Val Leu

40 45 50aag agt tcg gtg cgc att acg tgc acg ggc aac acg gtg gta acg cag 307Lys Ser Ser Val Arg Ile Thr Cys Thr Gly Asn Thr Val Val Thr Gln

55 60 65ccg ctg acg gac tcg ggt agg gca gtg gtt gcg cgc cta acg cag cag 355Pro Leu Thr Asp Ser Gly Arg Ala Val Val Ala Arg Leu Thr Gln Gln 70 75 80 85ctt ggc cag tac aac acc gca gag aac acc ttt agc ttc ccc gcc tca 403Leu Gly Gln Tyr Asn Thr Ala Glu Asn Thr Phe Ser Phe Pro Ala Ser

90 95 100gat gcg gtt gat gag cgc gag cgc ctc acc gca cca agc acc atc gaa 451Asp Ala Val Asp Glu Arg Glu Arg Leu Thr Ala Pro Ser Thr Ile Glu

105 110 115gtg ctg cgc aag ttg cag ttc gag tcc ggt tac agc gac gcg tcc ctg 499Val Leu Arg Lys Leu Gln Phe Glu Ser Gly Tyr Ser Asp Ala Ser Leu

120 125 130cca ctg ctc atg ggc ggt ttc gcg ttt gat ttc tta gaa acc ttt gaa 547Pro Leu Leu Met Gly Gly Phe Ala Phe Asp Phe Leu Glu Thr Phe Glu

135 140 145acg ctc ccc gct gtc gag gag agc gtc aac act tac ccc gat tac cag 595Thr Leu Pro Ala Val Glu Glu Ser Val Asn Thr Tyr Pro Asp Tyr Gln150 155 160 165ttc gtc ctc gcg gaa atc gtc ctg gac atc aat cac cag gac cag acc 643Phe Val Leu Ala Glu Ile Val Leu Asp Ile Asn His Gln Asp Gln Thr

170 175 180gcc aaa ctc gcc ggc gtc tcc aac gcc cca ggc gag ctc gag gcc gag 691Ala Lys Leu Ala Gly Val Ser Asn Ala Pro Gly Glu Leu Glu Ala Glu

185 190 195ctc aac aag ctt tca ttg ctt atc gac gcc gcc ctc ccc gca acc gaa 739Leu Asn Lys Leu Ser Leu Leu Ile Asp Ala Ala Leu Pro Ala Thr Glu

200 205 210cac gcc tac caa acc acc cct cac gac ggc gac act ctt cgc gtt gtg 787His Ala Tyr Gln Thr Thr Pro His Asp Gly Asp Thr Leu Arg Val Val

215 220 225gct gat att ccc gat gct cag ttc cgc acc cag atc aat gag ctg aaa 835Ala Asp Ile Pro Asp Ala Gln Phe Arg Thr Gln Ile Asn Glu Leu Lys230 235 240 245gaa aac att tac aac ggt gac atc tac caa gtt gtc ccg gcg cgc act 883Glu Asn Ile Tyr Asn Gly Asp Ile Tyr Gln Val Val Pro Ala Arg Thr

250 255 260ttc acc gca cca tgt cct gat gca ttc gct gct tat ctg cag ctg cgt 931Phe Thr Ala Pro Cys Pro Asp Ala Phe Ala Ala Tyr Leu Gln Leu Arg

265 270 275gcc acc aac ccg tcg ccg tac atg ttc tat atc cgt ggc ctc aac gaa 979Ala Thr Asn Pro Ser Pro Tyr Met Phc Tyr Ile Arg Gly Leu Asn Glu

280 285 290ggc cgc tcc tat gaa ctt ttt ggc gca tcc cct gag tcc aac ctc aag 1027Gly Arg Ser Tyr Glu Leu Phe Gly Ala Ser Pro Glu Set Asn Leu Lys

295 300 305ttc acc gct gct aac cgt gag ctg cag ctg tac cca atc gca ggt acc 1075Phe Thr Ala Ala Asn Arg Glu Leu Gln Leu Tyr Pro Ile Ala Gly Thr310 315 320 325cgc ccc cgt gga ctc aac cca gat ggc tcc atc aac gat gag cta gat 1123Arg Pro Arg Gly Leu Asn Pro Asp Gly Ser Ile Asn Asp Glu Leu Asp

330 335 340atc cgc aat gag ttg gat atg cgc act gat gcc aaa gag atc gcg gag 1171Ile Arg Asn Glu Leu Asp Met Arg Thr Asp Ala Lys Glu Ile Ala Glu

345 350 355cac acc atg ctt gtc gat ctc gcc cgc aac gac ctg gcc cgc gtc tcg 1219His Thr Met Leu Val Asp Leu Ala Arg Asn Asp Leu Ala Arg Val Ser

360 365 370gtc cca gcg tcg cgc cgg gtt gcg gat ctt ttg cag gtg gat cgc tat 1267Val Pro Ala Ser Arg Arg Val Ala Asp Leu Leu Gln Val Asp Arg Tyr

375 380 385tcc cgc gtg atg cac ttg gtg tcc cgt gtg acg gcg acg ttg gac cca 1315Ser Arg Val Met His Leu Val Ser Arg Val Thr Ala Thr Leu Asp Pro390 395 400 405gag ctt gat gct ttg gac gcc tat cgg gcg tgc atg aat atg ggc acg 1363Glu Leu Asp Ala Leu Asp Ala Tyr Arg Ala Cys Met Asn Met Gly Thr

410 415 420ttg acc ggc gct ccg aag ttg cgc gct atg gag ctg ttg cgc ggc gtc 1411Leu Thr Gly Ala Pro Lys Leu Arg Ala Met Glu Leu Leu Arg Gly Val

425 430 435gaa aag cgc agg cgt ggt tct tat ggt ggg gca gtg ggg tac ctg cgc 1459Glu Lys Arg Arg Arg Gly Ser Tyr Gly Gly Ala Val Gly Tyr Leu Arg

440 445 450ggc aat ggc gat atg gat aat tgc att gtt att cgt tcg gcg ttt gtc 1507Gly Asn Gly Asp Met Asp Asn Cys Ile Val Ile Arg Ser Ala Phe Val

455 460 465cag gat ggt gtg gct gct gtg cag gct ggt gct ggt gtg gtc cgc gat 1555Gln Asp Gly Val Ala Ala Val Gln Ala Gly Ala Gly Val Val Arg Asp470 475 480 485tct aat cct caa tct gaa gcc gat gag acg ttg cac aag gcg tat gcc 1603Ser Asn Pro Gln Ser Glu Ala Asp Glu Thr Leu His Lys Ala Tyr Ala

490 495 500gtg ttg aat gcc att gcg ctt gct gct ggt tcc act ttg gag gtc atc 1651Val Leu Asn Ala Ile Ala Leu Ala Ala Gly Ser Thr Leu Glu Val Ile

505510515 cga tgacacacgt tgttctcatt gat 1677Arg<210>420<211>518<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>420Met Ser Thr Asn Pro His Val Phe Ser Leu Asp Val Arg Tyr His Glu 151015 Asp Ala Ser Ala Leu Phe Ala His Leu Gly Gly Thr Thr Ala Asp Asp

20 25 30Ala Ala Leu Leu Glu Ser Ala Asp Ile Thr Thr Lys Asn Gly Ile Ser

35 40 45Ser Leu Ala Val Leu Lys Ser Ser Val Arg Ile Thr Cys Thr Gly Asn

50 55 60Thr Val Val Thr Gln Pro Leu Thr Asp Ser Gly Arg Ala Val Val Ala 65 70 75 80Arg Leu Thr Gln Gln Leu Gly Gln Tyr Asn Thr Ala Glu Asn Thr Phe

85 90 95Ser Phe Pro Ala Ser Asp Ala Val Asp Glu Arg Glu Arg Leu Thr Ala

100 105 110Pro Ser Thr Ile Glu Val Leu Arg Lys Leu Gln Phe Glu Ser Gly Tyr

115 120 125Ser Asp Ala Ser Leu Pro Leu Leu Met Gly Gly Phe Ala Phe Asp Phe

130 135 140Leu Glu Thr Phe Glu Thr Leu Pro Ala Val Glu Glu Ser Val Asn Thr145 150 155 160Tyr Pro Asp Tyr Gln Phe Val Leu Ala Glu Ile Val Leu Asp Ile Asn

165 170 175His Gln Asp Gln Thr Ala Lys Leu Ala Gly Val Ser Asn Ala Pro Gly

180 185 190Glu Leu Glu Ala Glu Leu Asn Lys Leu Ser Leu Leu Ile Asp Ala Ala

195 200 205Leu Pro Ala Thr Glu His Ala Tyr Gln Thr Thr Pro His Asp Gly Asp

210 215 220Thr Leu Arg Val Val Ala Asp Ile Pro Asp Ala Gln Phe Arg Thr Gln225 230 235 240Ile Asn Glu Leu Lys Glu Asn Ile Tyr Asn Gly Asp Ile Tyr Gln Val

245 250 255Val Pro Ala Arg Thr Phe Thr Ala Pro Cys Pro Asp Ala Phe Ala Ala

260 265 270Tyr Leu Gln Leu Arg Ala Thr Asn Pro Ser Pro Tyr Met Phe Tyr Ile

275 280 285Arg Gly Leu Asn Glu Gly Arg Ser Tyr Glu Leu Phe Gly Ala Ser Pro

290 295 300Glu Ser Asn Leu Lys Phe Thr Ala Ala Asn Arg Glu Leu Gln Leu Tyr305 310 315 320Pro Ile Ala Gly Thr Arg Pro Arg Gly Leu Asn Pro Asp Gly Ser Ile

325 330 335Asn Asp Glu Leu Asp Ile Arg Asn Glu Leu Asp Met Arg Thr Asp Ala

340 345 350Lys Glu Ile Ala Glu His Thr Met Leu Val Asp Leu Ala Arg Asn Asp

355 360 365Leu Ala Arg Val Ser Val Pro Ala Ser Arg Arg Val Ala Asp Leu Leu

370 375 380Gln Val Asp Arg Tyr Ser Arg Val Met His Leu Val Ser Arg Val Thr385 390 395 400Ala Thr Leu Asp Pro Glu Leu Asp Ala Leu Asp Ala Tyr Arg Ala Cys

405 410 415Met Asn Met Gly Thr Leu Thr Gly Ala Pro Lys Leu Arg Ala Met Glu

420 425 430Leu Leu Arg Gly Val Glu Lys Arg Arg Arg Gly Ser Tyr Gly Gly Ala

435 440 445Val Gly Tyr Leu Arg Gly Asn Gly Asp Met Asp Asn Cys Ile Val Ile

450 455 460Arg Ser Ala Phe Val Gln Asp Gly Val Ala Ala Val Gln Ala Gly Ala465 470 475 480Gly Val Val Arg Asp Ser Asn Pro Gln Ser Glu Ala Asp Glu Thr Leu

485490 495His Lys Ala Tyr Ala Val Leu Asn Ala Ile Ala Leu Ala Ala Gly Ser

500 505 510Thr Leu Glu Val Ile Arg

515<210>421<211>1151<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (1128)<223>FRXA00957<400>421gat ttc tta gaa acc ttt gaa acg ctc ccc gct gtc gag gag agc gtc 48Asp Phe Leu Glu Thr Phe Glu Thr Leu Pro Ala Val Glu Glu Set Val 151015 aac act tac ccc gat tac cag ttc gtc ctc gcg gaa atc gtc ctg gac 96<10>421 96Asn Thr Tyr Pro Asp Tyr Gln Phe Val Leu Ala Glu Ile Val Leu Asp

20 25 30atc aat cac cag gac cag acc gcc aaa ctc gcc ggc gtc tcc aac gcc 144Ile Asn His Gln Asp Gln Thr Ala Lys Leu Ala Gly Val Ser Asn Ala

35 40 45cca ggc gag ctc gag gcc gag ctc aac aag ctt tca ttg ctt atc gac 192Pro Gly Glu Leu Glu Ala Glu Leu Asn Lys Leu Ser Leu Leu Ile Asp

50 55 60gcc gcc ctc ccc gca acc gaa cac gcc tac caa acc acc cct cac gac 240Ala Ala Leu Pro Ala Thr Glu His Ala Tyr Gln Thr Thr Pro His Asp 65 70 75 80ggc gac act ctt cgc gtt gtg gct gat att ccc gat gct cag ttc cgc 288Gly Asp Thr Leu Arg Val Val Ala Asp Ile Pro Asp Ala Gln Phe Arg

85 90 95acc cag atc aat gag ctg aaa gaa aac att tac aac ggt gac atc tac 336Thr Gln Ile Asn Glu Leu Lys Glu Asn Ile Tyr Asn Gly Asp Ile Tyr

100 105 110caa gtt gtc ccg gcg cgc act ttc acc gca cca tgt cct gat gca ttc 384Gln Val Val Pro Ala Arg Thr Phe Thr Ala Pro Cys Pro Asp Ala Phe

115 120 125gct gct tat ctg cag ctg cgt gcc acc aac ccg tcg ccg tac atg ttc 432Ala Ala Tyr Leu Gln Leu Arg Ala Thr Asn Pro Ser Pro Tyr Met Phe

130 135 140tat atc cgt ggc ctc aac gaa ggc cgc tcc tat gaa ctt ttt ggc gca 480Tyr Ile Arg Gly Leu Asn Glu Gly Arg Ser Tyr Glu Leu Phe Gly Ala145 150 155 160tcc cct gag tcc aac ctc aag ttc acc gct gct aac cgt gag ctg cag 528Ser Pro Glu Ser Asn Leu Lys Phe Thr Ala Ala Asn Arg Glu Leu Gln

165 170 175ctg tac cca atc gca ggt acc cgc ccc cgt gga ctc aac cca gat ggc 576Leu Tyr Pro Ile Ala Gly Thr Arg Pro Arg Gly Leu Asn Pro Asp Gly

180 185 190tcc atc aac gat gag cta gat atc cgc aat gag ttg gat atg cgc act 624Ser Ile Asn Asp Glu Leu Asp Ile Arg Asn Glu Leu Asp Met Arg Thr

195 200 205gat gcc aaa gag atc gcg gag cac acc atg ctt gtc gat ctc gcc cgc 672Asp Ala Lys Glu Ile Ala Glu His Thr Met Leu Val Asp Leu Ala Arg

210 215 220aac gac ctg gcc cgc gtc tcg gtc cca gcg tcg cgc cgg gtt gcg gat 720Asn Asp Leu Ala Arg Val Ser Val Pro Ala Ser Arg Arg Val Ala Asp225 230 235 240ctt ttg cag gtg gat cgc tat tcc cgc gtg atg cac ttg gtg tcc cgt 768Leu Leu Gln Val Asp Arg Tyr Ser Arg Val Met His Leu Val Ser Arg

245 250 255gtg acg gcg acg ttg gac cca gag ctt gat gct ttg gac gcc tat cgg 816Val Thr Ala Thr Leu Asp Pro Glu Leu Asp Ala Leu Asp Ala Tyr Arg

260 265 270gcg tgc atg aat atg ggc acg ttg acc ggc gct ccg aagttg cgc gct 864Ala Cys Met Asn Met Gly Thr Leu Thr Gly Ala Pro Lys Leu Arg Ala

275 280 285atg gag ctg ttg cgc ggc gtc gaa aag cgc agg cgt ggt tct tat ggt 912Met Glu Leu Leu Arg Gly Val Glu Lys Arg Arg Arg Gly Ser Tyr Gly

290 295 300ggg gca gtg ggg tac ctg cgc ggc aat ggc gat atg gat aat tgc att 960Gly Ala Val Gly Tyr Leu Arg Gly Asn Gly Asp Met Asp Asn Cys Ile305 310 315 320gtt att cgt tcg gcg ttt gtc cag gat ggt gtg gct gct gtg cag gct 1008Val Ile Arg Ser Ala Phe Val Gln Asp Gly Val Ala Ala Val Gln Ala

325 330 335ggt gct ggt gtg gtc cgc gat tct aat cct caa tct gaa gcc gat gag 1056Gly Ala Gly Val Val Arg Asp Ser Asn Pro Gln Ser Glu Ala Asp Glu

340 345 350acg ttg cac aag gcg tat gcc gtg ttg aat gcc att gcg ctt gct gct 1104Thr Leu His Lys Ala Tyr Ala Val Leu Asn Ala Ile Ala Leu Ala Ala

355 360 365ggt tcc act ttg gag gtc atc cga tgacacacgt tgttctcatt gat 1151Gly Ser Thr Leu Glu Val Ile Arg

370375<210>422<211>376<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>422Asp Phe Leu Glu Thr Phe Glu Thr Leu Pro Ala Val Glu Glu Ser Val 151015 Asn Thr Tyr Pro Asp Tyr Gln Phe Val Leu Ala Glu Ile Val Leu Asp

20 25 30Ile Asn His Gln Asp Gln Thr Ala Lys Leu Ala Gly Val Ser Asn Ala

35 40 45Pro Gly Glu Leu Glu Ala Glu Leu Asn Lys Leu Ser Leu Leu Ile Asp

50 55 60Ala Ala Leu ProAla Thr Glu His Ala Tyr Gln Thr Thr Pro His Asp 65 70 75 80Gly Asp Thr Leu Arg Val Val Ala Asp Ile Pro Asp Ala Gln Phe Arg

85 90 95Thr Gln Ile Asn Glu Leu Lys Glu Asn Ile Tyr Asn Gly Asp Ile Tyr

100 105 110Gln Val Val Pro Ala Arg Thr Phe Thr Ala Pro Cys Pro Asp Ala Phe

115 120 125Ala Ala Tyr Leu Gln Leu Arg Ala Thr Asn Pro Ser Pro Tyr Met Phe

130 135 140Tyr Ile Arg Gly Leu Asn Glu Gly Arg Ser Tyr Glu Leu Phe Gly Ala145 150 155 160Ser Pro Glu Ser Asn Leu Lys Phe Thr Ala Ala Asn Arg Glu Leu Gln

165 170 175Leu Tyr Pro Ile Ala Gly Thr Arg Pro Arg Gly Leu Asn Pro Asp Gly

180 185 190Ser Ile Asn Asp Glu Leu Asp Ile Arg Asn Glu Leu Asp Met Arg Thr

195 200 205Asp Ala Lys Glu Ile Ala Glu His Thr Met Leu Val Asp Leu Ala Arg

210 215 220Asn Asp Leu Ala Arg Val Ser Val Pro Ala Ser Arg Arg Val Ala Asp225 230 235 240Leu Leu Gln Val Asp Arg Tyr Ser Arg Val Met His Leu Val Ser Arg

245 250 255Val Thr Ala Thr Leu Asp Pro Glu Leu Asp Ala Leu Asp Ala Tyr Arg

260 265 270Ala Cys Met Asn Met Gly Thr Leu Thr Gly Ala Pro Lys Leu Arg Ala

275 280 285Met Glu Leu Leu Arg Gly Val Glu Lys Arg Arg Arg Gly Ser Tyr Gly

290 295 300Gly Ala Val Gly Tyr Leu Arg Gly Asn Gly Asp Met Asp Asn Cys Ile305 310 315 320Val Ile Arg Ser Ala Phe Val Gln Asp Gly Val Ala Ala Val Gln Ala

325 330 335Gly Ala Gly Val Val Arg Asp Ser Asn Pro Gln Ser Glu Ala Asp Glu

340 345 350Thr Leu His Lys Ala Tyr Ala Val Leu Asn Ala Ile Ala Leu Ala Ala

355 360 365Gly Ser Thr Leu Glu Val Ile Arg

370375<210>423<211>1068<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1045)<223>RXA02687<400>423caaaaccatg ctcggcgggg gagagttggg ccaagcggtt cgctaattga gcaacagaca 60tggacaccca ccttagttcg gcgggttaag ctgtgtaacc atg agc gac gca cca 115

Met Ser Asp Ala Pro

1 5act gtt gtg gcc tat ttg ggg cct gcc gga acc ttc acc gaa gaa gcc 163Thr Val Val Ala Tyr Leu Gly Pro Ala Gly Thr Phe Thr Glu Glu Ala

10 15 20ctc tac aaa ttt gcc gac gcc ggc gta ttc ggc gac ggt gag atc gag 211Leu Tyr Lys Phe Ala Asp Ala Gly Val Phe Gly Asp Gly Glu Ile Glu

25 30 35cag cta cca gcc aaa tcg cca caa gaa gct gtc gac gcc gtc cgc cac 259Gln Leu Pro Ala Lys Ser Pro Gln Glu Ala Val Asp Ala Val Arg His

40 45 50ggc acc gcc cag ttc gcg gtg gtc gcc atc gaa aac ttc gtc gac ggc 307GlyThr Ala Gln Phe Ala Val Val Ala Ile Glu Asn Phe Val Asp Gly

55 60 65ccc gtc acc ccc acc ttc gac gcc ctt gac cag ggc tcc aac gtg caa 355Pro Val Thr Pro Thr Phe Asp Ala Leu Asp Gln Gly Ser Asn Val Gln 70 75 80 85atc atc gcc gaa gaa gaa ctc gac atc gcc ttt tcc atc atg gtc cgg 403Ile Ile Ala Glu Glu Glu Leu Asp Ile Ala Phe Ser Ile Met Val Arg

90 95 100cca ggg act tcg ctt gcc gac gtc aaa acc ctc gcc acc cac ccg gtt 451Pro Gly Thr Ser Leu Ala Asp Val Lys Thr Leu Ala Thr His Pro Val

105 110 115ggg tac caa caa gtg aaa aac tgg atg gca acc acc att ccg gac gcc 499Gly Tyr Gln Gln Val Lys Asn Trp Met Ala Thr Thr Ile Pro Asp Ala

120 125 130atg tat ctt tca gca agc tcc aac ggc gcc ggc gca caa atg gtt gcc 547Met Tyr Leu Ser Ala Ser Ser Asn Gly Ala Gly Ala Gln Met Val Ala

135 140 145gaa gga acc gcc gac gca gcc gca gcg ccc tcc cgc gca gcc gaa ctc 595Glu Gly Thr Ala Asp Ala Ala Ala Ala Pro Ser Arg Ala Ala Glu Leu150 155 160 165ttc gga ctg gaa cgc ctt gtt gat gat gtc gcc gac gtc cgt ggc gcc 643Phe Gly Leu Glu Arg Leu Val Asp Asp Val Ala Asp Val Arg Gly Ala

170 175 180cgc acc cgc ttc gtt gct gtc caa gcc caa gca gcc gtt tcc gaa ccg 691Arg Thr Arg Phe Val Ala Val Gln Ala Gln Ala Ala Val Ser Glu Pro

185 190 195acc ggc cac gac cgc acc tcc gtc att ttc tcc cta ccg aat gtg cca 739Thr Gly His Asp Arg Thr Ser Val Ile Phe Ser Leu Pro Asn Val Pro

200205 210ggc agc ctc gtg cgc gcc ctc aac gaa ttc gcc atc cgc ggc gtt gac 787Gly Ser Leu Val Arg Ala Leu Asn Glu Phe Ala Ile Arg Gly Val Asp

215 220 225ctc acc cgc atc gaa tcc cgc ccc acc cgc aaa gtc ttc gga acc tac 835Leu Thr Arg Ile Glu Ser Arg Pro Thr Arg Lys Val Phe Gly Thr Tyr230 235 240 245cgc ttc cac ctg gac ata tcc gga cat atc cgc gat atc ccc gtc gcc 883Arg Phe His Leu Asp Ile Ser Gly His Ile Arg Asp Ile Pro Val Ala

250 255 260gaa gcc ctc cgc gca ctc cac ctc caa gcc gaa gaa ctc gtc ttc gtc 931Glu Ala Leu Arg Ala Leu His Leu Gln Ala Glu Glu Leu Val Phe Val

265 270 275ggc tcc tgg ccc tcc aac cgt gcg gaa gac agc acg ccc caa acc gac 979Gly Ser Trp Pro Ser Asn Arg Ala Glu Asp Ser Thr Pro Gln Thr Asp

280 285 290caa cta gct aag cta cac aag gcg gac gaa tgg gtt cgc gca gca agc 1027Gln Leu Ala Lys Leu His Lys Ala Asp Glu Trp Val Arg Ala Ala Ser

295300305 gaa gga agg aaa ctt aac tagccatggc cggccggatt att 1068Glu Gly Arg Lys Leu Asn 310315 310210<210>424<211>315<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>424Met Ser Asp Ala Pro Thr Val Val Ala Tyr Leu Gly Pro Ala Gly Thr 151015 Phe Thr Glu Glu Ala Leu Tyr Lys Phe Ala Asp Ala Gly Val Phe Gly

20 25 30Asp Gly Glu Ile Glu Gln Leu Pro Ala Lys Ser Pro Gln Glu Ala Val

35 40 45Asp Ala Val Arg His Gly Thr Ala Gln Phe Ala Val Val Ala Ile Glu

50 55 60Asn PheVal Asp Gly Pro Val Thr Pro Thr Phe Asp Ala Leu Asp Gln 65 70 75 80Gly Ser Asn Val Gln Ile Ile Ala Glu Glu Glu Leu Asp Ile Ala Phe

85 90 95Ser Ile Met Val Arg Pro Gly Thr Ser Leu Ala Asp Val Lys Thr Leu

100 105 110Ala Thr His Pro Val Gly Tyr Gln Gln Val Lys Asn Trp Met Ala Thr

115 120 125Thr Ile Pro Asp Ala Met Tyr Leu Ser Ala Ser Ser Asn Gly Ala Gly

130 135 140Ala Gln Met Val Ala Glu Gly Thr Ala Asp Ala Ala Ala Ala Pro Ser145 150 155 160Arg Ala Ala Glu Leu Phe Gly Leu Glu Arg Leu Val Asp Asp Val Ala

165 170 175Asp Val Arg Gly Ala Arg Thr Arg Phe Val Ala Val Gln Ala Gln Ala

180 185 190Ala Val Ser Glu Pro Thr Gly His Asp Arg Thr Ser Val Ile Phe Ser

195 200 205Leu Pro Asn Val Pro Gly Ser Leu Val Arg Ala Leu Asn Glu Phe Ala

210 215 220Ile Arg Gly Val Asp Leu Thr Arg Ile Glu Ser Arg Pro Thr Arg Lys225 230 235 240Val Phe Gly Thr Tyr Arg Phe His Leu Asp Ile Ser Gly His Ile Arg

245 250 255Asp Ile Pro Val Ala Glu Ala Leu Arg Ala Leu His Leu Gln Ala Glu

260 265 270Glu Leu Val Phe Val Gly Ser Trp Pro Ser Asn Arg Ala Glu Asp Ser

275 280 285Thr Pro Gln Thr Asp Gln Leu Ala Lys Leu His Lys Ala Asp Glu Trp

290295300 Val Arg Ala Ala Ser Glu Gly Arg Lys Leu Asn 305310315<210>425<211>1353<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) · (1330)<223>RXN01698<400>425cgctagtgcc tgcagttatg tcgctttttg acgtcgaaaa gcaattttaa aaagcccttg 60gggtgggctg gatacgtctt ctgcggcctt tcgtgcgata atg cta ggc atg ctt 115

Met Leu Gly Met Leu

1 5cga tgg act aca gca ggt gaa tcc cac ggc cag gcg ctt atc gcc acg 163Arg Trp Thr Thr Ala Gly Glu Ser His Gly Gln Ala Leu Ile Ala Thr

10 15 20gtt gaa cac atg cca gca ggc gtg ccc gtg act aaa gat gag gtc tcg 211Val Glu His Met Pro Ala Gly Val Pro Val Thr Lys Asp Glu Val Ser

25 30 35tat caa ttg gcg cgc cga cgc ctt gga tat ggt cgc ggc gct cgc atg 259Tyr Gln Leu Ala Arg Arg Arg Leu Gly Tyr Gly Arg Gly Ala Arg Met

40 45 50aag ttt gag caa gac gcg ttg acc ttc ctc acc ggc atc cgc cac ggc 307Lys Phe Glu Gln Asp Ala Leu Thr Phe Leu Thr Gly Ile Arg His Gly

55 60 65ctc act ttg ggt agc ccc atc tca atc atg atc ggc aac act gag tgg 355Leu Thr Leu Gly Ser Pro Ile Ser Ile Met Ile Gly Asn Thr Glu Trp 70 75 80 85gat aag tgg acc acc atc atg tcc tct gac gct ttg gac atg gaa gac 403Asp Lys Trp Thr Thr Ile Met Ser Ser Asp Ala Leu Asp Met Glu Asp

90 95 100cca gat aac gtt gcg gcg atg tct tcg ggt cgg ggc gca aaa ctg act451Pro Asp Asn Val Ala Ala Met Ser Ser Gly Arg Gly Ala Lys Leu Thr

105 110 115cgt ccg cgt cca ggc cac gct gat tac gca ggc atg ctc aag tac gga 499Arg Pro Arg Pro Gly His Ala Asp Tyr Ala Gly Met Leu Lys Tyr Gly

120 125 130ttc gat gat gcc cgc aac gtg ctg gag cgt tct tca gcc cgt gag acg 547Phe Asp Asp Ala Arg Asn Val Leu Glu Arg Ser Ser Ala Arg Glu Thr

135 140 145gca gca cgc gtg gca gca gca acc gtt gcg cgt tcc ttc ctg cgt gaa 595Ala Ala Arg Val Ala Ala Ala Thr Val Ala Arg Ser Phe Leu Arg Glu150 155 160 165acc ttg ggc gtg gaa gtg ctt tcc cac gta att tcc att ggt gcg tcc 643Thr Leu Gly Val Glu Val Leu Ser His Val Ile Ser Ile Gly Ala Ser

170 175 180gag cct tac act ggc gcg gag cca acc ttt gca gat att caa gca atc 691Glu Pro Tyr Thr Gly Ala Glu Pro Thr Phe Ala Asp Ile Gln Ala Ile

185 190 195gat gat tcc cca gtt cgt gca ttc ggt aaa gac gct gaa gaa tcc atg 739Asp Asp Ser Pro Val Arg Ala Phe Gly Lys Asp Ala Glu Glu Ser Met

200 205 210atc gcg gaa atc gag gcc gca aag aaa gcc ggc gat acc ctc ggt ggc 787Ile Ala Glu Ile Glu Ala Ala Lys Lys Ala Gly Asp Thr Leu Gly Gly

215 220 225atc gtg gaa gtg att gtt gaa ggc ctg ccc atc ggt ttg ggc tca cac 835Ile Val Glu Val Ile Val Glu Gly Leu Pro Ile Gly Leu Gly Ser His230 235 240 245att tct ggc gaa gat cgc ctc gat gcg cag atc gca gct gca ctc atg 883Ile Ser Gly Glu Asp Arg Leu Asp Ala Gln Ile Ala Ala Ala Leu Met

250255 260ggc att cag gcc atc aag ggc gtg gaa atc ggt gac ggt ttc gaa gaa 931Gly Ile Gln Ala Ile Lys Gly Val Glu Ile Gly Asp Gly Phe Glu Glu

265 270 275gct cgt cga cgt ggc tcc gaa gcc cac gat gaa gtg ttc ctg gat gac 979Ala Arg Arg Arg Gly Ser Glu Ala His Asp Glu Val Phe Leu Asp Asp

280 285 290aac ggc gta tac cgc aac acc aac cgt gca ggt ggc ctc gaa ggc ggc 1027Asn Gly Val Tyr Arg Asn Thr Asn Arg Ala Gly Gly Leu Glu Gly Gly

295 300 305atg acc aac ggt gaa acc ctg cgc gtt cgt gct ggc atg aag cca att 1075Met Thr Asn Gly Glu Thr Leu Arg Val Arg Ala Gly Met Lys Pro Ile310 315 320 325tct act gtg cct cgc gcc ctg aaa acc att gat atg gaa aac ggc aag 1123Ser Thr Val Pro Arg Ala Leu Lys Thr Ile Asp Met Glu Asn Gly Lys

330 335 340gca gca acc gga atc cac cag cgt tcc gac gtg tgc gct gtt cca gcc 1171Ala Ala Thr Gly Ile His Gln Arg Ser Asp Val Cys Ala Val Pro Ala

345 350 355gcc ggt gtc gtt gca gaa gca atg gtc acc ctg gtt ctc gcc cgc gca 1219Ala Gly Val Val Ala Glu Ala Met Val Thr Leu Val Leu Ala Arg Ala

360 365 370gtc ctg cag aaa ttc ggc ggt gac tcc ctg agc gaa acc aag agc aac 1267Val Leu Gln Lys Phe Gly Gly Asp Ser Leu Ser Glu Thr Lys Ser Asn

375 380 385att gac acc tac ctc aaa aac att gag gaa cga atg aaa ttc gaa ggt 1315Ile Asp Thr Tyr Leu Lys Asn Ile Glu Glu Arg Met Lys Phe Glu Gly390 395 400 405tta gag gat gga gcg taatgaagtg aatgatcaaa ttc 1353LeuGlu Asp Gly Ala

410<210>426<211>410<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>426Met Leu Gly Met Leu Arg Trp Thr Thr Ala Gly Glu Ser His Gly Gln 151015 Ala Leu Ile Ala Thr Val Glu His Met Pro Ala Gly Val Pro Val Thr

20 25 30Lys Asp Glu Val Ser Tyr Gln Leu Ala Arg Arg Arg Leu Gly Tyr Gly

35 40 45Arg Gly Ala Arg Met Lys Phe Glu Gln Asp Ala Leu Thr Phe Leu Thr

50 55 60Gly Ile Arg His Gly Leu Thr Leu Gly Ser Pro Ile Ser Ile Met Ile 65 70 75 80Gly Asn Thr Glu Trp Asp Lys Trp Thr Thr Ile Met Ser Ser Asp Ala

85 90 95Leu Asp Met Glu Asp Pro Asp Asn Val Ala Ala Met Ser Ser Gly Arg

100 105 110Gly Ala Lys Leu Thr Arg Pro Arg Pro Gly His Ala Asp Tyr Ala Gly

115 120 125Met Leu Lys Tyr Gly Phe Asp Asp Ala Arg Asn Val Leu Glu Arg Ser

130 135 140Ser Ala Arg Glu Thr Ala Ala Arg Val Ala Ala Ala Thr Val Ala Arg145 150 155 160Ser Phe Leu Arg Glu Thr Leu Gly Val Glu Val Leu Ser His Val Ile

165 170 175Ser Ile Gly Ala Ser Glu Pro Tyr Thr Gly Ala Glu Pro Thr Phe Ala

180 185 190Asp Ile Gln Ala Ile Asp Asp Ser Pro Val Arg Ala Phe Gly Lys Asp

195 200 205Ala Glu Glu Ser Met Ile Ala GluIle Glu Ala Ala Lys Lys Ala Gly

210 215 220Asp Thr Leu Gly Gly Ile Val Glu Val Ile Val Glu Gly Leu Pro Ile225 230 235 240Gly Leu Gly Ser His Ile Ser Gly Glu Asp Arg Leu Asp Ala Gln Ile

245 250 255Ala Ala Ala Leu Met Gly Ile Gln Ala Ile Lys Gly Val Glu Ile Gly

260 265 270Asp Gly Phe Glu Glu Ala Arg Arg Arg Gly Ser Glu Ala His Asp Glu

275 280 285Val Phe Leu Asp Asp Asn Gly Val Tyr Arg Asn Thr Asn Arg Ala Gly

290 295 300Gly Leu Glu Gly Gly Met Thr Asn Gly Glu Thr Leu Arg Val Arg Ala305 310 315 320Gly Met Lys Pro Ile Ser Thr Val Pro Arg Ala Leu Lys Thr Ile Asp

325 330 335Met Glu Asn Gly Lys Ala Ala Thr Gly Ile His Gln Arg Ser Asp Val

340 345 350Cys Ala Val Pro Ala Ala Gly Val Val Ala Glu Ala Met Val Thr Leu

355 360 365Val Leu Ala Arg Ala Val Leu Gln Lys Phe Gly Gly Asp Ser Leu Ser

370 375 380Glu Thr Lys Ser Asn Ile Asp Thr Tyr Leu Lys Asn Ile Glu Glu Arg385 390 395 400Met Lys Phe Glu Gly Leu Glu Asp Gly Ala

405410<210>427<211>1013<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (990)<223>FRXA01698<400>427ggc aac act gag tgg gat aag tgg acc acc atc atg tcc tct gac gct 48GlyAsn Thr Glu Trp Asp Lys Trp Thr Thr Ile Met Ser Ser Asp Ala 151015 ttg gac atg gaa gac cca gat aac gtt gcg gcg atg tct tcg ggt cgg 96Leu Asp Met Glu Asp Pro Asp Asn Val Ala Ala Met Ser Ser Gly Arg

20 25 30ggc gca aaa ctg act cgt ccg cgt cca ggc cac gct gat tac gca ggc 144Gly Ala Lys Leu Thr Arg Pro Arg Pro Gly His Ala Asp Tyr Ala Gly

35 40 45atg ctc aag tac gga ttc gat gat gcc cgc aac gtg ctg gag cgt tct 192Met Leu Lys Tyr Gly Phe Asp Asp Ala Arg Asn Val Leu Glu Arg Ser

50 55 60tca gcc cgt gag acg gca gca cgc gtg gca gca gca acc gtt gcg cgt 240Ser Ala Arg Glu Thr Ala Ala Arg Val Ala Ala Ala Thr Val Ala Arg 65 70 75 80tcc ttc ctg cgt gaa acc ttg ggc gtg gaa gtg ctt tcc cac gta att 288Ser Phe Leu Arg Glu Thr Leu Gly Val Glu Val Leu Ser His Val Ile

85 90 95tcc att ggt gcg tcc gag cct tac act ggc gcg gag cca acc ttt gca 336Ser Ile Gly Ala Ser Glu Pro Tyr Thr Gly Ala Glu Pro Thr Phe Ala

100 105 110gat att caa gca atc gat gat tcc cca gtt cgt gca ttc ggt aaa gac 384Asp Ile Gln Ala Ile Asp Asp Ser Pro Val Arg Ala Phe Gly Lys Asp

115 120 125gct gaa gaa tcc atg atc gcg gaa atc gag gcc gca aag aaa gcc ggc 432Ala Glu Glu Ser Met Ile Ala Glu Ile Glu Ala Ala Lys Lys Ala Gly

130 135 140gat acc ctc ggt ggc atc gtg gaa gtg att gtt gaa ggc ctg ccc atc 480Asp Thr Leu Gly Gly Ile Val Glu Val Ile Val Glu Gly Leu Pro Ile145 150 155 160ggt ttg ggc tca cac att tct ggc gaa gat cgc ctc gat gcgcag atc 528Gly Leu Gly Ser His Ile Ser Gly Glu Asp Arg Leu Asp Ala Gln Ile

165 170 175gca gct gca ctc atg ggc att cag gcc atc aag ggc gtg gaa atc ggt 576Ala Ala Ala Leu Met Gly Ile Gln Ala Ile Lys Gly Val Glu Ile Gly

180 185 190gac ggt ttc gaa gaa gct cgt cga cgt ggc tcc gaa gcc cac gat gaa 624Asp Gly Phe Glu Glu Ala Arg Arg Arg Gly Ser Glu Ala His Asp Glu

195 200 205gtg ttc ctg gat gac aac ggc gta tac cgc aac acc aac cgt gca ggt 672Val Phe Leu Asp Asp Asn Gly Val Tyr Arg Asn Thr Asn Arg Ala Gly

210 215 220ggc ctc gaa ggc ggc atg acc aac ggt gaa acc ctg cgc gtt cgt gct 720Gly Leu Glu Gly Gly Met Thr Asn Gly Glu Thr Leu Arg Val Arg Ala225 230 235 240ggc atg aag cca att tct act gtg cct cgc gcc ctg aaa acc att gat 768Gly Met Lys Pro Ile Ser Thr Val Pro Arg Ala Leu Lys Thr Ile Asp

245 250 255atg gaa aac ggc aag gca gca acc gga atc cac cag cgt tcc gac gtg 816Met Glu Asn Gly Lys Ala Ala Thr Gly Ile His Gln Arg Ser Asp Val

260 265 270tgc gct gtt cca gcc gcc ggt gtc gtt gca gaa gca atg gtc acc ctg 864Cys Ala Val Pro Ala Ala Gly Val Val Ala Glu Ala Met Val Thr Leu

275 280 285gtt ctc gcc cgc gca gtc ctg cag aaa ttc ggc ggt gac tcc ctg agc 912Val Leu Ala Arg Ala Val Leu Gln Lys Phe Gly Gly Asp Ser Leu Ser

290 295 300gaa acc aag agc aac att gac acc tac ctc aaa aac att gag gaa cga 960Glu Thr Lys Ser Asn Ile Asp Thr Tyr Leu Lys Asn Ile Glu Glu Arg305310 315 320atg aaa ttc gaa ggt tta gag gat gga gcg taatgaagtg aatgatcaaa 1010Met Lys Phe Glu Gly Leu Glu Asp Gly Ala

325330 ttc 1013<210>428<211>330<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>428Gly Asn Thr Glu Trp Asp Lys Trp Thr Thr Ile Met Ser Ser Asp Ala 151015 Leu Asp Met Glu Asp Pro Asp Asn Val Ala Ala Met Ser Ser Gly Arg

20 25 30Gly Ala Lys Leu Thr Arg Pro Arg Pro Gly His Ala Asp Tyr Ala Gly

35 40 45Met Leu Lys Tyr Gly Phe Asp Asp Ala Arg Asn Val Leu Glu Arg Ser

50 55 60Ser Ala Arg Glu Thr Ala Ala Arg Val Ala Ala Ala Thr Val Ala Arg 65 70 75 80Ser Phe Leu Arg Glu Thr Leu Gly Val Glu Val Leu Ser His Val Ile

85 90 95Ser Ile Gly Ala Ser Glu Pro Tyr Thr Gly Ala Glu Pro Thr Phe Ala

100 105 110Asp Ile Gln Ala Ile Asp Asp Ser Pro Val Arg Ala Phe Gly Lys Asp

115 120 125Ala Glu Glu Ser Met Ile Ala Glu Ile Glu Ala Ala Lys Lys Ala Gly

130 135 140Asp Thr Leu Gly Gly Ile Val Glu Val Ile Val Glu Gly Leu Pro Ile145 150 155 160Gly Leu Gly Ser His Ile Ser Gly Glu Asp Arg Leu Asp Ala Gln Ile

165 170 175Ala Ala Ala Leu Met Gly Ile Gln Ala Ile Lys Gly Val Glu Ile Gly

180 185 190Asp Gly Phe Glu Glu Ala Arg ArgArg Gly Ser Glu Ala His Asp Glu

195 200 205Val Phe Leu Asp Asp Asn Gly Val Tyr Arg Asn Thr Asn Arg Ala Gly

210 215 220Gly Leu Glu Gly Gly Met Thr Asn Gly Glu Thr Leu Arg Val Arg Ala225 230 235 240Gly Met Lys Pro Ile Ser Thr Val Pro Arg Ala Leu Lys Thr Ile Asp

245 250 255Met Glu Asn Gly Lys Ala Ala Thr Gly Ile His Gln Arg Ser Asp Val

260 265 270Cys Ala Val Pro Ala Ala Gly Val Val Ala Glu Ala Met Val Thr Leu

275 280 285Val Leu Ala Arg Ala Val Leu Gln Lys Phe Gly Gly Asp Ser Leu Ser

290 295 300Glu Thr Lys Ser Asn Ile Asp Thr Tyr Leu Lys Asn Ile Glu Glu Arg305 310 315 320Met Lys Phe Glu Gly Leu Glu Asp Gly Ala

325330<210>429<211>906<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (883)<223>RXA01095<400>429gaaaccccag gtcaaagcta gggtgtggca ccctgatttc tttcgccatg tgtgttcggg 60ataaccttaa acacagcatt ggttggaagg aggttggggc atg gtt gca aca gag 115

Met Val Ala Thr Glu

1 5aac cgc atg ttg atg gaa atc gct gcg gaa ata tcg gct cgg gaa gca 163Asn Arg Met Leu Met Glu Ile Ala Ala Glu Ile Ser Ala Arg Glu Ala

10 15 20acg ctt ggt ttt caa gaa gtc aaa act aaa tct cga tca gca ggt ctc 211Thr Leu Gly Phe Gln GluVal Lys Thr Lys Ser Arg Ser Ala Gly Leu

25 30 35acg gcg gct ttc gat att gct tca gtc ttt ttt tcg tct gga tgt aat 259Thr Ala Ala Phe Asp Ile Ala Ser Val Phe Phe Ser Ser Gly Cys Asn

40 45 50gtc gta gtc gcc ttt gat cgt ttt gca tcc aat tgg tct gat cat tcg 307Val Val Val Ala Phe Asp Arg Phe Ala Ser Asn Trp Ser Asp His Ser

55 60 65gat cat gtg gac tac gct gca cag gtt gcg ggt ttt ggc gca tca atg 355Asp His Val Asp Tyr Ala Ala Gln Val Ala Gly Phe Gly Ala Ser Met 70 75 80 85ctt gca tat acg gtg cgc agg gga cag ttt gat acc gca gta cgc gat 403Leu Ala Tyr Thr Val Arg Arg Gly Gln Phe Asp Thr Ala Val Arg Asp

90 95 100atc agg gac atc aaa tct gaa gta gac att ccc att ctg ctt cat gat 451Ile Arg Asp Ile Lys Ser Glu Val Asp Ile Pro Ile Leu Leu His Asp

105 110 115ccc atc atc gat ccg tat caa atc cac gaa gcc cgc gtc atg ggc atc 499Pro Ile Ile Asp Pro Tyr Gln Ile His Glu Ala Arg Val Met Gly Ile

120 125 130gac gct ctt caa ttc ccc gta tgg gcg atg gaa caa gct cga ctg gaa 547Asp Ala Leu Gln Phe Pro Val Trp Ala Met Glu Gln Ala Arg Leu Glu

135 140 145tct ttg gtg gac cgc acc gaa tca ttg ggc atg aca gcc atc gtg tct 595Ser Leu Val Asp Arg Thr Glu Ser Leu Gly Met Thr Ala Ile Val Ser150 155 160 165gtg cga aac cac gaa gaa gcg cat cgt gca gtg gac gca gga gcg aca 643Val Arg Asn His Glu Glu Ala His Arg Ala Val Asp Ala Gly Ala Thr

170 175180gtg gta gca att gat att act ggt tat acc ggc tca ctc act ttg cct 691Val Val Ala Ile Asp Ile Thr Gly Tyr Thr Gly Ser Leu Thr Leu Pro

185 190 195gaa gcg ttt tcg ggt atc acc caa ttc atg ccc aaa gag gta gcc cgc 739Glu Ala Phe Ser Gly Ile Thr Gln Phe Met Pro Lys Glu Val Ala Arg

200 205 210att gtg ctc gga ggt tgc agc agc cct aaa gaa ctc atg cgg ttt gca 787Ile Val Leu Gly Gly Cys Ser Ser Pro Lys Glu Leu Met Arg Phe Ala

215 220 225cga cat tct gca gac gcc atc ttt gtt cca cat gca gac ctc gcc acc 835Arg His Ser Ala Asp Ala Ile Phe Val Pro His Ala Asp Leu Ala Thr230 235 240 245aca aaa tct ctt gtg aca gca ggt atg cat cca gcg tgc cca tcg cgt 883Thr Lys Ser Leu Val Thr Ala Gly Met His Pro Ala Cys Pro Ser Arg

250255260 tgaagaggtg ctctgtggtc agc 906<210>430<21l>261<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>430Met Val Ala Thr Glu Asn Arg Met Leu Met Glu Ile Ala Ala Glu Ile15 l 015 Ser Ala Arg Glu Ala Thr Leu Gly Phe Gln Glu Val Lys Thr Lys Ser

20 25 30Arg Ser Ala Gly Leu Thr Ala Ala Phe Asp Ile Ala Ser Val Phe Phe

35 40 45Ser Ser Gly Cys Asn Val Val Val Ala Phe Asp Arg Phe Ala Ser Asn

50 55 60Trp Ser Asp His Ser Asp His Val Asp Tyr Ala Ala Gln Val Ala Gly 65 70 75 80Phe Gly Ala Ser Met Leu Ala Tyr Thr Val Arg Arg Gly Gln Phe Asp

85 90 95Thr Ala Val Arg Asp Ile Arg Asp Ile Lys Ser Glu Val Asp Ile Pro

100 105 110Ile Leu Leu His Asp Pro Ile Ile Asp Pro Tyr Gln Ile His Glu Ala

115 120 125Arg Val Met Gly Ile Asp Ala Leu Gln Phe Pro Val Trp Ala Met Glu

130 135 140Gln Ala Arg Leu Glu Ser Leu Val Asp Arg Thr Glu Ser Leu Gly Met145 150 155 160Thr Ala Ile Val Ser Val Ara Asn His Glu Glu Ala His Arg Ala Val

165 170 175Asp Ala Gly Ala Thr Val Val Ala Ile Asp Ile Thr Gly Tyr Thr Gly

180 185 190Ser Leu Thr Leu Pro Glu Ala Phe Ser Gly Ile Thr Gln Phe Met Pro

195 200 205Lys Glu Val Ala Arg Ile Val Leu Gly Gly Cys Ser Ser Pro Lys Glu

210 215 220Leu Met Arg Phe Ala Arg His Ser Ala Asp Ala Ile Phe Val Pro His225 230 235 240Ala Asp Leu Ala Thr Thr Lys Ser Leu Val Thr Ala Gly Met His Pro

245 250 255Ala Cys Pro Ser Arg

260<210>431<211>1545<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1522)<223>RXA00955<400>431gatggtgcac aaaaggcgct ttccttgctt gccgacggca ccacccaggc atggttggcc 60aagcacgaag agatcgatta ctcagaaaag gagtcttcca atg act agt aat aat 115

Met Thr Ser Asn Asn

l 5ctgccc aca gtg ttg gaa agc atc gtc gag ggt cgt cgc gga cac ctg 163Leu Pro Thr Val Leu Glu Ser Ile Val Glu Gly Arg Arg Gly His Leu

10 15 20gag gaa att cgc gct cgc atc gct cac gtg gat gtg gat gcg ctt cca 211Glu Glu Ile Arg Ala Arg Ile Ala His Val Asp Val Asp Ala Leu Pro

25 30 35aaa tcc acc cgt tct ctg ttt gat tcc ctc aac cag ggt agg gga ggg 259Lys Ser Thr Arg Ser Leu Phe Asp Ser Leu Asn Gln Gly Arg Gly Gly

40 45 50gcg cgt ttc atc atg gag tgc aag tcc gca tcg cct tct ttg gga atg 307Ala Arg Phe Ile Met Glu Cys Lys Ser Ala Ser Pro Ser Leu Gly Met

55 60 65att cgt gag cac tac cag ccg ggt gaa atc gct cgc gtg tac tct cgc 355Ile Arg Glu His Tyr Gln Pro Gly Glu Ile Ala Arg Val Tyr Ser Arg 70 75 80 85tac gcc agc ggc att tcc gtg ctg tgc gag ccg gat cgt ttt ggt ggc 403Tyr Ala Ser Gly Ile Ser Val Leu Cys Glu Pro Asp Arg Phe Gly Gly

90 95 100gat tac gat cac ctc gct acc gtt gcc gct acc tct cat ctt ccg gtg 451Asp Tyr Asp His Leu Ala Thr Val Ala Ala Thr Ser His Leu Pro Val

105 110 115ctg tgc aaa gac ttc atc att gat cct gtc cag gta cac gcg gcg cgt 499Leu Cys Lys Asp Phe Ile Ile Asp Pro Val Gln Val His Ala Ala Arg

120 125 130tac ttt ggt gct gat gcc atc ctg ctc atg ctc tct gtg ctt gat gat 547Tyr Phe Gly Ala Asp Ala Ile Leu Leu Met Leu Ser Val Leu Asp Asp

135 140 145gaa gag tac gca gca ctc gct gcc gag gct gcg cgt ttt gat ctg gat 595Glu Glu Tyr Ala Ala Leu Ala Ala Glu Ala Ala Arg PheAsp Leu Asp150 155 160 165atc ctc acc gag gtt att gat gag gag gaa gtc gcc cgc gcc atc aag 643Ile Leu Thr Glu Val Ile Asp Glu Glu Glu Val Ala Arg Ala Ile Lys

170 175 180ctg ggt gcg aag atc ttt ggc gtc aac cac cgc aac ctg cat gat ctg 691Leu Gly Ala Lys Ile Phe Gly Val Asn His Arg Asn Leu His Asp Leu

185 190 195tcc att gat ttg gat cgt tca cgt cgc ctg tcc aag ctc att cca gca 739Ser Ile Asp Leu Asp Arg Ser Arg Arg Leu Ser Lys Leu Ile Pro Ala

200 205 210gat gcc gtg ctc gtg tct gag tct ggc gtg cgc gat acc gaa acc gtc 787Asp Ala Val Leu Val Ser Glu Ser Gly Val Arg Asp Thr Glu Thr Val

215 220 225cgc cag cta ggt ggg cac tcc aat gca ttc ctc gtt ggc tcc cag ctg 835Arg Gln Leu Gly Gly His Ser Asn Ala Phe Leu Val Gly Ser Gln Leu230 235 240 245acc agc cag gaa aac gtc gat ctg gca gcc cgc gaa tta gtc tac ggc 883Thr Ser Gln Glu Asn Val Asp Leu Ala Ala Arg Glu Leu Val Tyr Gly

250 255 260ccc aac aaa gtc tgc gga ctc acc tca cca agt gca gca caa acc gct 931Pro Asn Lys Val Cys Gly Leu Thr Ser Pro Ser Ala Ala Gln Thr Ala

265 270 275cgc gca gcg ggt gcg gtc tac ggc ggg ctc atc ttc gaa gag gca tcg 979Arg Ala Ala Gly Ala ValTyr Gly Gly Leu Ile Phe Glu Glu Ala Ser

280 285 290cca cgc aat gtt tca cgt gaa aca ttg caa aaa atc atc gcc gca gag 1027Pro Arg Asn Val Ser Arg Glu Thr Leu Gln Lys Ile Ile Ala Ala Glu

295 300 305ccc aac ctg cgc tacgtc gcg gtc agc cgt cgc acc tcc ggg tac aag 1075Pro Asn Leu Arg Tyr Val Ala Val Ser Arg Arg Thr Ser Gly Tyr Lys310 315 320 325gat ttg ctt gtc gac ggc atc ttc gcc gta caa atc cac gcc cca ctg 1123Asp Leu Leu Val Asp Gly Ile Phe Ala Val Gln Ile His Ala Pro Leu

330 335 340cag gac agc gtc gaa gca gaa aag gca ttg atc gcc gcc gtt cgt gaa 1171Gln Asp Ser Val Glu Ala Glu Lys Ala Leu Ile Ala Ala Val Arg Glu

345 350 355gag gtt gga ccg cag gtc cag gtc tgg cgc gcg atc tcg atg tcc agc 1219Glu Val Gly Pro Gln Val Gln Val Trp Arg Ala Ile Ser Met Ser Ser

360 365 370ccc ttg ggg gct gaa gtg gca gct gcg gtg gag ggt gac gtc gat aag 1267Pro Leu Gly Ala Glu Val Ala Ala Ala Val Glu Gly Asp Val Asp Lys

375 380 385cta att ctt gat gcc cat gaa ggt ggc agc ggg gaa gta ttc gac tgg 1315Leu Ile Leu Asp Ala His Glu Gly Gly Ser Gly Glu Val Phe Asp Trp390 395 400 405gct acg gtg ccg gcc gct gtg aag gca aag tct ttg ctc gcg gga ggc 1363Ala Thr Val Pro Ala Ala Val Lys Ala Lys Ser Leu Leu Ala Gly Gly

410 415 420atc tct ccg gac aac gct gcg cag gca ctc gct gtg ggc tgc gca ggt 1411Ile Ser Pro Asp Asn Ala Ala Gln Ala Leu Ala Val Gly Cys Ala Gly

425 430 435ttg gac atc aac tct ggc gtg gaa tac ccc gcc ggt gca ggc acg tgg 1459Leu Asp Ile Asn Ser Gly Val Glu Tyr Pro Ala Gly Ala Gly Thr Trp

440 445 450gct ggg gcg aaa gac gcc ggc gcg ctg ctg aaa att tta gcg acc atc 1507Ala Gly Ala Lys Asp Ala Gly Ala Leu Leu Lys IleLeu Ala Thr Ile

455460465 tcc aca ttc cat tac taaaggttta aataggatca tga 1545Ser Thr Phe His Tyr470<210>432<211>474<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>432Met Thr Ser Asn Asn Leu Pro Thr Val Leu Glu Ser Ile Val Glu Gly 151015 Arg Arg Gly His Leu Glu Glu Ile Arg Ala Arg Ile Ala His Val Asp

20 25 30Val Asp Ala Leu Pro Lys Ser Thr Arg Ser Leu Phe Asp Ser Leu Asn

35 40 45Gln Gly Arg Gly Gly Ala Arg Phe Ile Met Glu Cys Lys Ser Ala Ser

50 55 60Pro Ser Leu Gly Met Ile Arg Glu His Tyr Gln Pro Gly Glu Ile Ala 65 70 75 80Arg Val Tyr Ser Arg Tyr Ala Ser Gly Ile Ser Val Leu Cys Glu Pro

85 90 95Asp Arg Phe Gly Gly Asp Tyr Asp His Leu Ala Thr Val Ala Ala Thr

100 105 110Ser His Leu Pro Val Leu Cys Lys Asp Phe Ile Ile Asp Pro Val Gln

115 120 125Val His Ala Ala Arg Tyr Phe Gly Ala Asp Ala Ile Leu Leu Met Leu

130 135 140Ser Val Leu Asp Asp Glu Glu Tyr Ala Ala Leu Ala Ala Glu Ala Ala145 150 155 160Arg Phe Asp Leu Asp Ile Leu Thr Glu Val Ile Asp Glu Glu Glu Val

165 170 175Ala Arg Ala Ile Lys Leu Gly Ala Lys Ile Phe Gly Val Asn His Arg

180 185 190Asn Leu His Asp Leu Ser Ile Asp Leu Asp Arg Ser Arg Arg Leu Ser

195200 205Lys Leu Ile Pro Ala Asp Ala Val Leu Val Ser Glu Ser Gly Val Arg

210 215 220Asp Thr Glu Thr Val Arg Gln Leu Gly Gly His Ser Asn Ala Phe Leu225 230 235 240Val Gly Ser Gln Leu Thr Ser Gln Glu Asn Val Asp Leu Ala Ala Arg

245 250 255Glu Leu Val Tyr Gly Pro Asn Lys Val Cys Gly Leu Thr Ser Pro Ser

260 265 270Ala Ala Gln Thr Ala Arg Ala Ala Gly Ala Val Tyr Gly Gly Leu Ile

275 280 285Phe Glu Glu Ala Ser Pro Arg Asn Val Ser Arg Glu Thr Leu Gln Lys

290 295 300Ile Ile Ala Ala Glu Pro Asn Leu Arg Tyr Val Ala Val Ser Arg Arg305 310 315 320Thr Ser Gly Tyr Lys Asp Leu Leu Val Asp Gly Ile Phe Ala Val Gln

325 330 335Ile His Ala Pro Leu Gln Asp Ser Val Glu Ala Glu Lys Ala Leu Ile

340 345 350Ala Ala Val Arg Glu Glu Val Gly Pro Gln Val Gln Val Trp Arg Ala

355 360 365Ile Ser Met Ser Ser Pro Leu Gly Ala Glu Val Ala Ala Ala Val Glu

370 375 380Gly Asp Val Asp Lys Leu Ile Leu Asp Ala His Glu Gly Gly Ser Gly385 390 395 400Glu Val Phe Asp Trp Ala Thr Val Pro Ala Ala Val Lys Ala Lys Ser

405 410 415Leu Leu Ala Gly Gly Ile Ser Pro Asp Asn Ala Ala Gln Ala Leu Ala

420425 430Val Gly Cys Ala Gly Leu Asp Ile Asn Ser Gly Val Glu Tyr Pro Ala

435 440 445Gly Ala Gly Thr Trp Ala Gly Ala Lys Asp Ala Gly Ala Leu Leu Lys

450455460 Ile Leu Ala Thr Ile Ser Thr Phe His Tyr 465470<210>433<211>494<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) · (471)<223>RXA02814<400>433gcc aaa aac cta gaa gaa cac tcc tac gtg gtc aac cac ctg cgc acc 48Ala Lys Asn Leu Glu Glu His Ser Tyr Val Val Asn His Leu Arg Thr 151015 atc ctg gaa cca ctg tgc tca caa ttc gac gcc cca aca gtt cct gaa 96Ile Leu Glu Pro Leu Cys Ser Gln Phe Asp Ala Pro Thr Val Pro Glu<400>433 3532,015

20 25 30ctg acc aaa acc aac gaa atg tgg cac ctc gca aca ccc atc gtt ggc 144Leu Thr Lys Thr Asn Glu Met Trp His Leu Ala Thr Pro Ile Val Gly

35 40 45acc ctc aag tac cca cac atc acc gca cta gaa cta gcc ata cga aca 192Thr Leu Lys Tyr Pro His Ile Thr Ala Leu Glu Leu Ala Ile Arg Thr

50 55 60cac ccc acc ccc gcg atc tgt ggc acc ccc acc gac gcc gcc gaa gcc 240His Pro Thr Pro Ala Ile Cys Gly Thr Pro Thr Asp Ala Ala Glu Ala 65 70 75 80ctc atc atc gaa gcg gaa tcc ccc cga aac ttc tac gcc gga gca gcc 288Leu Ile Ile Glu Ala Glu Ser Pro Arg Asn Phe Tyr Ala Gly Ala Ala

85 90 95ggc tgg tgt gac tcc acc gga gac ggc gaa tac atg gta gcc atc cgc 336Gly Trp Cys Asp Ser Thr Gly Asp Gly Glu Tyr Met Val Ala Ile Arg

100 105 110tgc gcc gaa gta tcc gaa gac gga acc tgg gcc aga gca tgg gca ggc 384Cys Ala Glu Val Ser Glu Asp Gly Thr Trp Ala Arg Ala Trp Ala Gly

115 120 125gga ggc atc gtc gcc gaa tca gac gcc caa gaa gag ttt gat gaa acc 432Gly Gly Ile Val Ala Glu Ser Asp Ala Gln Glu Glu Phe Asp Glu Thr

130135140 acc gcg aag ctc caa acc atc atg cgc tcg ctt ggt ttg tgagatgtgg 481Thr Ala Lys Leu Gln Thr Ile Met Arg Ser Leu Gly Leu 145150155 tcttaaaaca ccg 494<210>434<211>157<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>434Ala Lys Asn Leu Glu Glu His Ser Tyr Val Val Asn His Leu Arg Thr 151015 Ile Leu Glu Pro Leu Cys Ser Gln Phe Asp Ala Pro Thr Val Pro Glu

20 25 30Leu Thr Lys Thr Asn Glu Met Trp His Leu Ala Thr Pro Ile Val Gly

35 40 45Thr Leu Lys Tyr Pro His Ile Thr Ala Leu Glu Leu Ala Ile Arg Thr

50 55 60His Pro Thr Pro Ala Ile Cys Gly Thr Pro Thr Asp Ala Ala Glu Ala 65 70 75 80Leu Ile Ile Glu Ala Glu Ser Pro Arg Asn Phe Tyr Ala Gly Ala Ala

85 90 95Gly Trp Cys Asp Ser Thr Gly Asp Gly Glu Tyr Met Val Ala Ile Arg

100 105 110Cys Ala Glu Val Ser Glu Asp Gly Thr Trp Ala Arg Ala Trp Ala Gly

115 120 125Gly Gly Ile Val Ala Glu Ser Asp Ala Gln Glu Glu Phe Asp Glu Thr

130135140 Thr Ala Lys Leu Gln Thr Ile Met Arg Ser Leu Gly Leu 145150155<210>435<211>803<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1).<780)<223>RXA00229<400>435gag gcg aaa ggc ctc gcg cag gga cgt gcg acg gtg tac agg cgc atc 48Glu Ala Lys Gly Leu Ala Gln Gly Arg Ala Thr Val Tyr Arg Arg Ile 151015 gac acg ctt ggg tcg cgt gct tcc ggg caa gat tta aat acg ctt ctc 96Asp Thr Leu Gly Ser Arg Ala Ser Gly Gln Asp Leu Asn Thr Leu Leu

20 25 30gac gcc gcc ctc tac ctt ggc ttc agc ggc ctg aac atc act cac ccg 144Asp Ala Ala Leu Tyr Leu Gly Phe Ser Gly Leu Asn Ile Thr His Pro

35 40 45tac aag caa gca gta tta ccc ctg ctt ggc gaa gtc tcc gaa caa gcc 192Tyr Lys Gln Ala Val Leu Pro Leu Leu Gly Glu Val Ser Glu Gln Ala

50 55 60acc caa ctc ggc gca gtg aat act gtc gtt atg gac gcc acc ggc cac 240Thr Gln Leu Gly Ala Val Asn Thr Val Val Met Asp Ala Thr Gly His 65 70 75 80acc acc ggc cac aac acc gac gtc tcc gga ttt ggc cgc gga atg gaa 288Thr Thr Gly His Asn Thr Asp Val Ser Gly Phe Gly Arg Gly Met Glu

85 90 95gaa ggc ctc ccc aac gcc aag ctc gat tcc gtc gtg cag gtc ggc gcc 336Glu Gly Leu Pro Asn Ala Lys Leu Asp Ser Val Val Gln Val Gly Ala

100 105 110ggc ggc gta gaa aac gca gtg gca tac gcc ctg gtc acc cac ggt gtg 384Gly Gly Val Glu Asn Ala Val Ala Tyr Ala Leu Val Thr His Gly Val

115 120 125cag aaa ctt cag gtc gct gac ctc gac act tcc cgc gcg cag gca ctg 432Gln Lys Leu Gln Val Ala Asp Leu Asp Thr Ser Arg Ala Gln Ala Leu

130 135 140gca gat gtc atc aac aac gca gtc ggc cgt gaa gcc gtc gtg gga gta 480Ala Asp Val Ile Asn Asn Ala Val Gly ArgGlu Ala Val Val Gly Val145 150 155 160gac gcc cgc ggc atc gaa gac gtc atc gcc gcc gcc gac gga gta gtc 528Asp Ala Arg Gly Ile Glu Asp Val Ile Ala Ala Ala Asp Gly Val Val

165 170 175aac gca acc ccc atg gga atg cca gca cac ccc ggc acc gcc ttt gat 576Asn Ala Thr Pro Met Gly Met Pro Ala His Pro Gly Thr Ala Phe Asp

180 185 190gtc agc tgc ctc acc aag gat cac tgg gtt ggc gac gtc gtg tac atg 624Val Ser Cys Leu Thr Lys Asp His Trp Val Gly Asp Val Val Tyr Met

195 200 205ccc atc gaa act gaa ctt ctc aaa gcc gcc cgt gcc ctc ggc tgc gaa 672Pro Ile Glu Thr Glu Leu Leu Lys Ala Ala Arg Ala Leu Gly Cys Glu

210 215 220acc ctc gac gga acc cgc atg gca atc cac caa gcc gtc gat gcc ttc 720Thr Leu Asp Gly Thr Arg Met Ala Ile His Gln Ala Val Asp Ala Phe225 230 235 240cga ctg ttc acc ggc ctc gaa ccc gac gtc tcc cgc atg cgg gaa act 768Arg Leu Phe Thr Gly Leu Glu Pro Asp Val Ser Arg Met Arg Glu Thr

245 250 255ttc ctg tcc ctc taaaagagtc agtaaaacct cga 803Phe Leu Ser Leu

260<210>436<211>260<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>436Glu Ala Lys Gly Leu Ala Gln Gly Arg Ala Thr Val Tyr Arg Arg Ile 151015 Asp Thr Leu Gly Ser Arg Ala Ser Gly Gln Asp Leu Asn Thr Leu Leu

20 25 30Asp Ala Ala Leu Tyr Leu Gly Phe Ser Gly Leu Asn Ile Thr His Pro

35 40 45Tyr Lys Gln Ala Val Leu Pro Leu LeuGly Glu Val Ser Glu Gln Ala

50 55 60Thr Gln Leu Gly Ala Val Asn Thr Val Val Met Asp Ala Thr Gly His 65 70 75 80Thr Thr Gly His Asn Thr Asp Val Ser Gly Phe Gly Arg Gly Met Glu

85 90 95Glu Gly Leu Pro Asn Ala Lys Leu Asp Ser Val Val Gln Val Gly Ala

100 105 110Gly Gly Val Glu Asn Ala Val Ala Tyr Ala Leu Val Thr His Gly Val

115 120 125Gln Lys Leu Gln Val Ala Asp Leu Asp Thr Ser Arg Ala Gln Ala Leu

130 135 140Ala Asp Val Ile Asn Asn Ala Val Gly Arg Glu Ala Val Val Gly Val145 150 155 160Asp Ala Arg Gly Ile Glu Asp Val Ile Ala Ala Ala Asp Gly Val Val

165 170 175Asn Ala Thr Pro Met Gly Met Pro Ala His Pro Gly Thr Ala Phe Asp

180 185 190Val Ser Cys Leu Thr Lys Asp His Trp Val Gly Asp Val Val Tyr Met

195 200 205Pro Ile Glu Thr Glu Leu Leu Lys Ala Ala Arg Ala Leu Gly Cys Glu

210 215 220Thr Leu Asp Gly Thr Arg Met Ala Ile His Gln Ala Val Asp Ala Phe225 230 235 240Arg Leu Phe Thr Gly Leu Glu Pro Asp Val Ser Arg Met Arg Glu Thr

245 250 255Phe Leu Ser Leu

260<210>437<211>927<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (904)<223>RXA02093<400>437ggcaggaatt tcccgaaaac ttccaccaat aatcaagcca tatcccacac aatcaggcat 60ttgctcttcc tttgctccgc atgagtataa aatcactgtc atg gtc aac tac gtc 115

Met Val Asn Tyr Val

1 5gac agg gaa aca acc ctg tgc atc tct ctc gct gct cgt cca tcc aac 163Asp Arg Glu Thr Thr Leu Cys Ile Ser Leu Ala Ala Arg Pro Ser Asn

10 15 20cat ggt gtt cgt ttc cac aac tgg ctt tac gct gaa ctt gga ttg aac 211His Gly Val Arg Phe His Asn Trp Leu Tyr Ala Glu Leu Gly Leu Asn

25 30 35tac ctg tac aag gct gtt gcc cca gca gat atc acc gct gca gtc gca 259Tyr Leu Tyr Lys Ala Val Ala Pro Ala Asp Ile Thr Ala Ala Val Ala

40 45 50ggt atc cgt ggt ctg aac att cgc ggc gca ggt gtc tcc atg cca tac 307Gly Ile Arg Gly Leu Asn Ile Arg Gly Ala Gly Val Ser Met Pro Tyr

55 60 65aag agc gat gtc atc cca ctc atc gat gag ttg cat cct tcc gca gag 355Lys Ser Asp Val Ile Pro Leu Ile Asp Glu Leu His Pro Ser Ala Glu 70 75 80 85cgc ata cgt tct gtt aac acc atc gtc aac aat gac gga cac ctt gtc 403Arg Ile Arg Ser Val Asn Thr Ile Val Asn Asn Asp Gly His Leu Val

90 95 100gga tac aac acc gac tac act gcg gtg tac cac ctc ctt gaa gaa cac 451Gly Tyr Asn Thr Asp Tyr Thr Ala Val Tyr His Leu Leu Glu Glu His

105 110 115cgc gtg aac ccc aat gca cga gta gct atc aag gga tcc ggc ggc atg 499Arg Val Asn Pro Asn Ala Arg Val Ala Ile Lys Gly Ser Gly Gly Met

120 125 130gcc aat gct gtt gtt gca gct ctt gct gag tat ggt ctg agt ggc acc 547Ala Asn Ala Val Val Ala Ala Leu Ala Glu Tyr Gly Leu Ser Gly Thr

135 140 145gtc gtt gcc cgc aac cac acc acc ggt tct gcg cta gct tcc cgt tac 595Val Val Ala Arg Asn His Thr Thr Gly Ser Ala Leu Ala Ser Arg Tyr150 155 160 165ggt tgg gaa tac tcc gca act gtt ccg gaa gac gca aaa att ttg gtt 643Gly Trp Glu Tyr Ser Ala Thr Val Pro Glu Asp Ala Lys Ile Leu Val

170 175 180aat gta acc cca atg gga atg aat gga cct gac caa gac gtt gta tct 691Asn Val Thr Pro Met Gly Met Asn Gly Pro Asp Gln Asp Val Val Ser

185 190 195ttt ggt gag gat gaa gta gac cga gcc gac gta atc ttt gac tgc gta 739Phe Gly Glu Asp Glu Val Asp Arg Ala Asp Val Ile Phe Asp Cys Val

200 205 210gca ttc ccc gtc gag acc cca ctg att aag ttg gcc aag gaa aag ggt 787Ala Phe Pro Val Glu Thr Pro Leu Ile Lys Leu Ala Lys Glu Lys Gly

215 220 225aag caa acc atc gac ggc gga gaa gtt gcc gct ctt cag gca gca gag 835Lys Gln Thr Ile Asp Gly Gly Glu Val Ala Ala Leu Gln Ala Ala Glu230 235 240 245cag ttc cac ctc tac acc gga gtt ctt cca acc aac gac cag atc att 883Gln Phe His Leu Tyr Thr Gly Val Leu Pro Thr Asn Asp Gln Ile Ile

250 255 260

gct gcg gag gag ttc tcc aag taaatttctc tcccctattt tta 927Ala Ala Glu Glu Phe Ser Lys

265<210>438<211>268<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>438Met Val Asn Tyr Val Asp Arg Glu Thr Thr Leu Cys Ile Ser Leu Ala 151015 Ala Arg Pro Ser Asn His Gly Val Arg Phe His Asn Trp Leu Tyr Ala

20 25 30Glu Leu Gly Leu Asn Tyr Leu Tyr Lys Ala Val Ala Pro Ala Asp Ile

35 40 45Thr Ala Ala Val Ala Gly Ile Arg Gly Leu Asn Ile Arg Gly Ala Gly

50 55 60Val Ser Met Pro Tyr Lys Ser Asp Val Ile Pro Leu Ile Asp Glu Leu 65 70 75 80His Pro Ser Ala Glu Arg Ile Arg Ser Val Asn Thr Ile Val Asn Asn

85 90 95Asp Gly His Leu Val Gly Tyr Asn Thr Asp Tyr Thr Ala Val Tyr His

100 105 110Leu Leu Glu Glu His Arg Val Asn Pro Asn Ala Arg Val Ala Ile Lys

115 120 125Gly Ser Gly Gly Met Ala Asn Ala Val Val Ala Ala Leu Ala Glu Tyr

130 135 140Gly Leu Ser Gly Thr Val Val Ala Arg Asn His Thr Thr Gly Ser Ala145 150 155 160Leu Ala Ser Arg Tyr Gly Trp Glu Tyr Ser Ala Thr Val Pro Glu Asp

165 170 175Ala Lys Ile Leu Val Asn Val Thr Pro Met Gly Met Asn Gly Pro Asp

180 185 190Gln Asp Val Val Ser Phe Gly Glu Asp Glu Val Asp Arg Ala Asp Val

195 200 205Ile Phe Asp Cys Val Ala Phe Pro Val Glu Thr Pro Leu Ile Lys Leu

210 215 220Ala Lys Glu Lys Gly Lys Gln Thr Ile Asp Gly Gly Glu Val Ala Ala225 230 235 240Leu Gln Ala Ala Glu Gln Phe His Leu Tyr Thr Gly Val Leu Pro Thr

245 250 255Asn Asp Gln Ile Ile Ala Ala Glu Glu Phe Ser Lys

260265<210>439<211>951<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (928)<223>RXA02791<400>439accgtgttca acgacacctt cgaagagcac gaagccgaca ttgagcaagc tttgaacagt 60ggcgttctag acagcaaccg ataaggatca gcgaataaaa ttg ggt tct cac atc 115

Leu Gly Ser His Ile

1 5act cac cgg gcg gcc gta ctc ggc tca ccc atc gag cat tcc aaa tcc 163Thr His Arg Ala Ala Val Leu Gly Ser Pro Ile Glu His Ser Lys Ser

10 15 20cca gtc ctc cac aac acc ggc tat aaa gcc ctc gga ctg gac caa tgg 211Pro Val Leu His Asn Thr Gly Tyr Lys Ala Leu Gly Leu Asp Gln Trp

25 30 35gaa tac gac cgc ttt gag tgc acc ggc gac atg ctc ccc ggc atc gtc 259Glu Tyr Asp Arg Phe Glu Cys Thr Gly Asp Met Leu Pro Gly Ile Val

40 45 50tcc ggc gct gat gaa acc tac tgc gga ttc tcc gtc acc atg ccg tct 307Ser Gly Ala Asp Glu Thr Tyr Cys Gly Phe Ser Val Thr Met Pro Ser

55 60 65aaa ttc gca gct ctt gaa ttc gcc gac gaa gta acc gaa cgc gcc tgc 355Lys Phe Ala Ala Leu Glu Phe Ala Asp Glu Val Thr Glu Arg Ala Cys 70 75 80 85gcc atc ggc tcc gca aac acc ttg ctg cgc acg gcc acc gga tgg cgc 403Ala Ile Gly Ser Ala Asn Thr Leu Leu Arg Thr Ala Thr Gly Trp Arg

90 95 100gcc gac aac acc gac gtc gac ggc atc agg gga gct ctc ggt gaa ctc 451Ala Asp Asn Thr Asp Val Asp Gly Ile Arg Gly Ala Leu Gly Glu Leu

105 110 115ctc ggc ggc gca tca ctg gcc ggc aaa cac gcc atc gtc atc ggc tcc 499Leu Gly Gly Ala Ser Leu Ala Gly Lys His Ala Ile Val Ile Gly Ser

120 125 130ggc ggc acc gca cgc ccc gcc atc tgg gca ctc atc gaa gcc ggg gtc 547Gly Gly Thr Ala Arg Pro Ala Ile Trp Ala Leu Ile Glu Ala Gly Val

135 140 145gcc cgg atc acg gtg ctc aac cgc tcc gat cgc acc gcc gaa ctg caa 595Ala Arg Ile Thr Val Leu Asn Arg Ser Asp Arg Thr Ala Glu Leu Gln150 155 160 165acg ctt ttc gac gaa acc ccc acc acc ttg gcc tac gcc ccg ctc gag 643Thr Leu Phe Asp Glu Thr Pro Thr Thr Leu Ala Tyr Ala Pro Leu Glu

170 175 180cat ctc cac atc gaa gcc gac gtc gta gtc tct aca gtg ccc tcc gca 691His Leu His Ile Glu Ala Asp Val Val Val Ser Thr Val Pro Ser Ala

185 190 195gca atc gca ggc ctc gaa gac acc ctt gcg atc gcc cca gtc ctc gac 739Ala Ile Ala Gly Leu Glu Asp Thr Leu Ala Ile Ala Pro Val Leu Asp

200 205 210gtc atc tac gac ccc tgg cca aca cca ctc gta gaa gtc aca cga gcc 787Val Ile Tyr Asp Pro Trp Pro Thr Pro Leu Val Glu Val Thr Arg Ala

215 220 225aaa ggc ctc aaa gct gtc gga ggc cac gtc atg ctg gca cac cag tcc 835Lys Gly Leu Lys Ala Val Gly Gly His Val Met Leu Ala His Gln Ser230 235 240245tac gga cag ttt gaa caa ttc acc gga atg gat gca ccc cgc gat gcc 883Tyr Gly Gln Phe Glu Gln Phe Thr Gly Met Asp Ala Pro Arg Asp Ala

250 255 260atg cgt gag gct ttg gaa gag tct tta ggc atc tca gaa gaa cac 928Met Arg Glu Ala Leu Glu Glu Ser Leu Gly Ile Ser Glu Glu His

265270275 taagtccccg ccacctcctc aac 951<210>440<211>276<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>440Leu Gly Ser His Ile Thr His Arg Ala Ala Val Leu Gly Ser Pro Ile 151015 Glu His Ser Lys Ser Pro Val Leu His Asn Thr Gly Tyr Lys Ala Leu

20 25 30Gly Leu Asp Gln Trp Glu Tyr Asp Arg Phe Glu Cys Thr Gly Asp Met

35 40 45Leu Pro Gly Ile Val Ser Gly Ala Asp Glu Thr Tyr Cys Gly Phe Ser

50 55 60Val Thr Met Pro Ser Lys Phe Ala Ala Leu Glu Phe Ala Asp Glu Val 65 70 75 80Thr Glu Arg Ala Cys Ala Ile Gly Ser Ala Asn Thr Leu Leu Arg Thr

85 90 95Ala Thr Gly Trp Arg Ala Asp Asn Thr Asp Val Asp Gly Ile Arg Gly

100 105 110Ala Leu Gly Glu Leu Leu Gly Gly Ala Ser Leu Ala Gly Lys His Ala

115 120 125Ile Val Ile Gly Ser Gly Gly Thr Ala Arg Pro Ala Ile Trp Ala Leu

130 135 140Ile Glu Ala Gly Val Ala Arg Ile Thr Val Leu Asn Arg Ser Asp Arg145 150 155 160Thr Ala Glu Leu Gln Thr Leu Phe Asp Glu Thr Pro Thr Thr Leu Ala

165 170 175Tyr Ala Pro Leu Glu His Leu His Ile Glu Ala Asp Val Val Val Ser

180 185 190Thr Val Pro Ser Ala Ala Ile Ala Gly Leu Glu Asp Thr Leu Ala Ile

195 200 205Ala Pro Val Leu Asp Val Ile Tyr Asp Pro Trp Pro Thr Pro Leu Val

210 215 220Glu Val Thr Arg Ala Lys Gly Leu Lys Ala Val Gly Gly His Val Met225 230 235 240Leu Ala His Gln Ser Tyr Gly Gln Phe Glu Gln Phe Thr Gly Met Asp

245 250 255Ala Pro Arg Asp Ala Met Arg Glu Ala Leu Glu Glu Ser Leu Gly Ile

260 265 270Ser Glu Glu His

275<210>441<211>693<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). - (670)<223>RXA01699<400>441ctgcagaaat tcggcggtga ctccctgagc gaaaccaaga gcaacattga cacctacctc 60aaaaacattg aggaacgaat gaaattcgaa ggtttagagg atg gag cgt aat gaa 115

Met Glu Arg Asn Glu

1 5gtg aat gat caa att cac tta gat cat caa tca gat gac acc tct gaa 163Val Asn Asp Gln Ile His Leu Asp His Gln Ser Asp Asp Thr Ser Glu

10 15 20tgc tcc tgc ccg atc gtg gtt ctt gtg ggt ttg cca gga gct gga aaa 211Cys Ser Cys Pro Ile Val Val Leu Val Gly Leu Pro Gly Ala Gly Lys

25 30 35tcc acc att gga cgt cga tta gcg cgc gcc tta aac act gaa ctc gtc 259Ser Thr Ile Gly Arg Arg Leu Ala Arg Ala Leu Asn Thr Glu Leu Val

40 45 50gac tcc gac gaa ctg att gag cgc gcc acc gga aaa gcc tgt ggc gcc 307Asp Ser Asp Glu Leu Ile Glu Arg Ala Thr Gly Lys Ala Cys Gly Ala

55 60 65gtg ttc agc gag ctc ggc gag cca gcc ttc cgc gag ctc gag gcc atc 355Val Phe Ser Glu Leu Gly Glu Pro Ala Phe Arg Glu Leu Glu Ala Ile 70 75 80 85cac gtg gcc gaa gca ctg aaa tcc tcc gga gtg gtg agc ttg gga ggc 403His Val Ala Glu Ala Leu Lys Ser Ser Gly Val Val Ser Leu Gly Gly

90 95 100gga tct gtg ctg aca gaa tcc acc cgt gaa ctg ctc aaa ggc cag gac 451Gly Ser Val Leu Thr Glu Ser Thr Arg Glu Leu Leu Lys Gly Gln Asp

105 110 115gtg gtc tgg atc gac gtg cca gta gaa gaa ggc atc agg cgc acc gca 499Val Val Trp Ile Asp Val Pro Val Glu Glu Gly Ile Arg Arg Thr Ala

120 125 130aac gag cgt tcc cgc ccc gtg ctg caa gcc gcc gac ccc gcc gag cac 547Asn Glu Arg Ser Arg Pro Val Leu Gln Ala Ala Asp Pro Ala Glu His

135 140 145tac cgc aac ctg gtg aaa gtg cgc acc ccg ttg tac gaa gag gtg gca 595Tyr Arg Asn Leu Val Lys Val Arg Thr Pro Leu Tyr Glu Glu Val Ala150 155 160 165acc tac cga ctt cgc acc aac aac cgc agc ccc cag caa gtg gtg gca 643Thr Tyr Arg Leu Arg Thr Asn Asn Arg Ser Pro Gln Gln Val Val Ala

170 175 180gca gtg ttg cat cat cta gaa atc gat taattaaacc gggcacctga 690Ala Val Leu His His Leu Glu Ile Asp

185190 tta 693<210>442<211>190<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>442Met Glu Arg Asn Glu Val Asn Asp Gln Ile His Leu Asp His Gln Ser 151015 Asp Asp Thr Ser Glu Cys Ser Cys Pro Ile Val Val Leu Val Gly Leu

20 25 30Pro Gly Ala Gly Lys Ser Thr Ile Gly Arg Arg Leu Ala Arg Ala Leu

35 40 45Asn Thr Glu Leu Val Asp Ser Asp Glu Leu Ile Glu Arg Ala Thr Gly

50 55 60Lys Ala Cys Gly Ala Val Phe Ser Glu Leu Gly Glu Pro Ala Phe Arg 65 70 75 80Glu Leu Glu Ala Ile His Val Ala Glu Ala Leu Lys Ser Ser Gly Val

85 90 95Val Ser Leu Gly Gly Gly Ser Val Leu Thr Glu Ser Thr Arg Glu Leu

100 105 110Leu Lys Gly Gln Asp Val Val Trp Ile Asp Val Pro Val Glu Glu Gly

115 120 125Ile Arg Arg Thr Ala Asn Glu Arg Ser Arg Pro Val Leu Gln Ala Ala

130 135 140Asp Pro Ala Glu His Tyr Arg Asn Leu Val Lys Val Arg Thr Pro Leu145 150 155 160Tyr Glu Glu Val Ala Thr Tyr Arg Leu Arg Thr Asn Asn Arg Ser Pro

165 170 175Gln Gln Val Val Ala Ala Val Leu His His Leu Glu Ile Asp

180185190<210>443<211>959<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(97) } (936)<223>RXA00952<400>443catcctcgtc tccctatccg gccgtggcga caaggacgtt gaccacgtgc gccgcaccct 60cgaagaaaat ccagaactga tcctgaagga caaccg atg agccgt tac gac gat 114

Met Ser Arg Tyr Asp Asp

1 5ctt ttt gca cgc ctc gac acg gca ggg gag ggc gcc ttt gtt ccc ttc 162Leu Phe Ala Arg Leu Asp Thr Ala Gly Glu Gly Ala Phe Val Pro Phe

10 15 20atc atg ctg agc gac cct tca cca gag gag gct ttc cag atc atc tcc 210Ile Met Leu Ser Asp Pro Ser Pro Glu Glu Ala Phe Gln Ile Ile Ser

25 30 35aca gca atc gaa gct ggc gca gat gca ctg gaa ctt ggc gta cct ttc 258Thr Ala Ile Glu Ala Gly Ala Asp Ala Leu Glu Leu Gly Val Pro Phe

40 45 50tcc gac cca gtt gcc gat ggc ccc acc gtc gcg gaa tcc cac ctc cgc 306Ser Asp Pro Val Ala Asp Gly Pro Thr Val Ala Glu Ser His Leu Arg 55 60 65 70gca ctc gac ggc ggc gcc acc gta gac agc gca ctc gag cag atc aag 354Ala Leu Asp Gly Gly Ala Thr Val Asp Ser Ala Leu Glu Gln Ile Lys

75 80 85cgc gtg cgc gca gcc tac cca gag gtt ccc atc gga atg ctc atc tac 402Arg Val Arg Ala Ala Tyr Pro Glu Val Pro Ile Gly Met Leu Ile Tyr

90 95 100ggc aac gtt cct ttc acc cgt ggc ttg gat cgc ttc tac caa gag ttc 450Gly Asn Val Pro Phe Thr Arg Gly Leu Asp Arg Phe Tyr Gln Glu Phe

105 110 115gct gaa gct ggc gca gac tcc atc ctc ctg cca gac gtc cca gtc cga 498Ala Glu Ala Gly Ala Asp Ser Ile Leu Leu Pro Asp Val Pro Val Arg

120 125 130gaa ggc gca ccg ttt tct gca gca gct gca gca gcc gga att gat ccc 546Glu Gly Ala Pro Phe Ser Ala Ala Ala AlaAla Ala Gly Ile Asp Pro135 140 145 150att tac atc gct ccg gcc aac gcc agc gag aaa acc ctc gag ggt gtc 594Ile Tyr Ile Ala Pro Ala Asn Ala Ser Glu Lys Thr Leu Glu Gly Val

155 160 165tcc gcc gca tca aag ggc tac atc tac gcc atc tcc cgc gac ggc gtc 642Ser Ala Ala Ser Lys Gly Tyr Ile Tyr Ala Ile Ser Arg Asp Gly Val

170 175 180acc ggc acc gaa cgt gaa tca tcc acc gac ggc ctg tcc gca gtg gtg 690Thr Gly Thr Glu Arg Glu Ser Ser Thr Asp Gly Leu Ser Ala Val Val

185 190 195gac aac atc aag aaa ttt gat ggc gca ccc atc ctc ttg ggc ttc ggc 738Asp Asn Ile Lys Lys Phe Asp Gly Ala Pro Ile Leu Leu Gly Phe Gly

200 205 210atc tca tcc cct cag cac gtg gca gac gcg att gca gcg ggt gct tcc 786Ile Ser Ser Pro Gln His Val Ala Asp Ala Ile Ala Ala Gly Ala Ser215 220 225 230ggt gcg atc acg ggt tcc gcg atc acc aag atc att gct tcc cac tgc 834Gly Ala Ile Thr Gly Ser Ala Ile Thr Lys Ile Ile Ala Ser His Cys

235 240 245gaa ggt gag cac ccg aac ccg tcc acc att cga gat atg gac ggt ttg 882Glu Gly Glu His Pro Asn Pro Ser Thr Ile Arg Asp Met Asp Gly Leu

250 255 260aag aag gat ctc act gag ttc atc tct gcg atg aag gca gcg acc aag 930Lys Lys Asp Leu Thr Glu Phe Ile Ser Ala Met Lys Ala Ala Thr Lys

265 270 275aag gtt taggccttta aatgtggcaa tgt 959Lys Val

280<210>444<211>280<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>444Met Ser Arg Tyr Asp Asp Leu Phe Ala Arg Leu Asp Thr Ala Gly Glu 151015 Gly Ala Phe Val Pro Phe Ile Met Leu Ser Asp Pro Ser Pro Glu Glu

20 25 30Ala Phe Gln Ile Ile Ser Thr Ala Ile Glu Ala Gly Ala Asp Ala Leu

35 40 45Glu Leu Gly Val Pro Phe Ser Asp Pro Val Ala Asp Gly Pro Thr Val

50 55 60Ala Glu Ser His Leu Arg Ala Leu Asp Gly Gly Ala Thr Val Asp Ser 65 70 75 80Ala Leu Glu Gln Ile Lys Arg Val Arg Ala Ala Tyr Pro Glu Val Pro

85 90 95Ile Gly Met Leu Ile Tyr Gly Asn Val Pro Phe Thr Arg Gly Leu Asp

100 105 110Arg Phe Tyr Gln Glu Phe Ala Glu Ala Gly Ala Asp Ser Ile Leu Leu

115 120 125Pro Asp Val Pro Val Arg Glu Gly Ala Pro Phe Ser Ala Ala Ala Ala

130 135 140Ala Ala Gly Ile Asp Pro Ile Tyr Ile Ala Pro Ala Asn Ala Ser Glu145 150 155 160Lys Thr Leu Glu Gly Val Ser Ala Ala Ser Lys Gly Tyr Ile Tyr Ala

165 170 175Ile Ser Arg Asp Gly Val Thr Gly Thr Glu Arg Glu Ser Ser Thr Asp

180 185 190Gly Leu Ser Ala Val Val Asp Asn Ile Lys Lys Phe Asp Gly Ala Pro

195 200 205Ile Leu Leu Gly Phe Gly Ile Ser Ser Pro Gln His Val Ala Asp Ala

210 215 220Ile Ala Ala Gly Ala Ser Gly Ala Ile Thr Gly Ser AlaIle Thr Lys225 230 235 240Ile Ile Ala Ser His Cys Glu Gly Glu His Pro Asn Pro Ser Thr Ile

245 250 255Arg Asp Met Asp Gly Leu Lys Lys Asp Leu Thr Glu Phe Ile Ser Ala

260 265 270Met Lys Ala Ala Thr Lys Lys Val

275280<210>445<211>1237<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1237)<223>RXN00956<400>445gccggtgcag gcacgtgggc tggggcgaaa gacgccggcg cgctgctgaa aattttagcg 60accatctcca cattccatta ctaaaggttt aaataggatc atg act gaa aaa gaa 115

Met Thr Glu Lys Glu

1 5aac ttg ggc ggc tcc acg ctg ctg cct gca tac ttc ggt gaa ttc ggc 163Asn Leu Gly Gly Ser Thr Leu Leu Pro Ala Tyr Phe Gly Glu Phe Gly

10 15 20ggc cag ttc gtc gcg gaa tcc ctc ctg cct gct ctc gac cag ctg gag 211Gly Gln Phe Val Ala Glu Ser Leu Leu Pro Ala Leu Asp Gln Leu Glu

25 30 35aag gcc ttc gtt gac gcg acc aac agc cca gag ttc cgc gaa gaa ctc 259Lys Ala Phe Val Asp Ala Thr Asn Ser Pro Glu Phe Arg Glu Glu Leu

40 45 50ggc ggc tac ctc cgc gat tac ctc ggc cgc cca acc ccg ctg acc gaa 307Gly Gly Tyr Leu Arg Asp Tyr Leu Gly Arg Pro Thr Pro Leu Thr Glu

55 60 65tgc tcc aac ctg cca ctc gca ggc gaa ggc aaa ggc ttt gcg cgg atc 355Cys Ser Asn Leu Pro Leu Ala Gly Glu Gly Lys Gly Phe Ala Arg Ile 70 7580 85ttc ctc aag cgc gaa gac ctc gtc cac ggc ggt gca cac aaa act aac 403Phe Leu Lys Arg Glu Asp Leu Val His Gly Gly Ala His Lys Thr Asn

90 95 100cag gtg atc ggc cag gtg ctg ctt gcc aag cgc atg ggc aaa acc cgc 451Gln Val Ile Gly Gln Val Leu Leu Ala Lys Arg Met Gly Lys Thr Arg

105 110 115atc atc gca gag acc ggc gca ggc cag cac ggc acc gcc acc gct ctc 499Ile Ile Ala Glu Thr Gly Ala Gly Gln His Gly Thr Ala Thr Ala Leu

120 125 130gca tgt gcg ctc atg ggc ctc gag tgc gtt gtc tac atg ggc gcc aag 547Ala Cys Ala Leu Met Gly Leu Glu Cys Val Val Tyr Met Gly Ala Lys

135 140 145gac gtt gcc cgc cag cag ccc aac gtc tac cgc atg cag ctg cac ggc 595Asp Val Ala Arg Gln Gln Pro Asn Val Tyr Arg Met Gln Leu His Gly150 155 160 165gcg aag gtc atc ccc gtg gaa tct ggt tcc ggc acc ctg aag gac gcc 643Ala Lys Val Ile Pro Val Glu Ser Gly Ser Gly Thr Leu Lys Asp Ala

170 175 180gtg aat gaa gcg ctg cgc gat tgg acc gca acc ttc cac gag tcc cac 691Val Asn Glu Ala Leu Arg Asp Trp Thr Ala Thr Phe His Glu Ser His

185 190 195tac ctt ctc ggc acc ccc gcc ggc ccg cac cca ttc cca acc atc gtg 739Tyr Leu Leu Gly Thr Pro Ala Gly Pro His Pro Phe Pro Thr Ile Val

200 205 210cgt gaa ttc cac aag gtg atc tct gag gaa gcc aag gca cag atg cta 787Arg Glu Phe His Lys Val Ile Ser Glu Glu Ala Lys Ala Gln Met Leu

215 220 225gag cgc acc ggc aag ctt ccc gac gtt gtg gtc gcc tgt gtc ggt ggt 835Glu Arg Thr Gly Lys Leu Pro Asp Val Val Val Ala Cys Val Gly Gly230 235 240 245ggc tcc aac gcc atc ggc atg ttc gca gac ttc att gac gat gaa ggt 883Gly Ser Asn Ala Ile Gly Met Phe Ala Asp Phe Ile Asp Asp Glu Gly

250 255 260gta gag ctc gtc ggc gct gag cca gcc ggt gaa ggc ctc gac tcc ggc 931Val Glu Leu Val Gly Ala Glu Pro Ala Gly Glu Gly Leu Asp Ser Gly

265 270 275aag cac ggc gca acc atc acc aac ggt cag atc ggc atc ctg cac ggc 979Lys His Gly Ala Thr Ile Thr Asn Gly Gln Ile Gly Ile Leu His Gly

280 285 290acc cgt tcc tac ctg atg cgc aac tcc gac ggc caa gtg gaa gag tcc 1027Thr Arg Ser Tyr Leu Met Arg Asn Ser Asp Gly Gln Val Glu Glu Ser

295 300 305tac tcc atc tcc gcc gga ctt gat tac cca ggc gtc ggc cca cag cac 1075Tyr Ser Ile Ser Ala Gly Leu Asp Tyr Pro Gly Val Gly Pro Gln His310 315 320 325gca cac ctg cac gcc acc ggc cgc gcc acc tac gtt ggt atc acc gac 1123Ala His Leu His Ala Thr Gly Arg Ala Thr Tyr Val Gly Ile Thr Asp

330 335 340gcc gaa gcc ctc caa gca ttc cag tac ctc gcc cgc tac gaa ggc atc 1171Ala Glu Ala Leu Gln Ala Phe Gln Tyr Leu Ala Arg Tyr Glu Gly Ile

345 350 355atc ccc gca ctg gaa tcc tca cac gcg ttc gcc tac gca ctc aag cgc 1219Ile Pro Ala Leu Glu Ser Ser His Ala Phe Ala Tyr Ala Leu Lys Arg

360 365 370gcc aag acc gcc gaa gta 1237Ala Lys Thr Ala Glu Val

375<210>446<211>379<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>446Met Thr Glu Lys Glu Asn Leu Gly Gly Ser Thr Leu Leu Pro Ala Tyr 151015 Phe Gly Glu Phe Gly Gly Gln Phe Val Ala Glu Ser Leu Leu Pro Ala

20 25 30Leu Asp Gln Leu Glu Lys Ala Phe Val Asp Ala Thr Asn Ser Pro Glu

35 40 45Phe Arg Glu Glu Leu Gly Gly Tyr Leu Arg Asp Tyr Leu Gly Arg Pro

50 55 60Thr Pro Leu Thr Glu Cys Ser Asn Leu Pro Leu Ala Gly Glu Gly Lys 65 70 75 80Gly Phe Ala Arg Ile Phe Leu Lys Arg Glu Asp Leu Val His Gly Gly

85 90 95Ala His Lys Thr Asn Gln Val Ile Gly Gln Val Leu Leu Ala Lys Arg

100 105 110Met Gly Lys Thr Arg Ile Ile Ala Glu Thr Gly Ala Gly Gln His Gly

115 120 125Thr Ala Thr Ala Leu Ala Cys Ala Leu Met Gly Leu Glu Cys Val Val

130 135 140Tyr Met Gly Ala Lys Asp Val Ala Arg Gln Gln Pro Asn Val Tyr Arg145 150 155 160Met Gln Leu His Gly Ala Lys Val Ile Pro Val Glu Ser Gly Ser Gly

165 170 175Thr Leu Lys Asp Ala Val Asn Glu Ala Leu Arg Asp Trp Thr Ala Thr

180 185 190Phe His Glu Ser His Tyr Leu Leu Gly Thr Pro Ala Gly Pro His Pro

195 200 205Phe Pro Thr Ile Val Arg Glu Phe His Lys Val Ile Ser Glu Glu Ala

210 215220Lys Ala Gln Met Leu Glu Arg Thr Gly Lys Leu Pro Asp Val Val Val225 230 235 240Ala Cys Val Gly Gly Gly Ser Asn Ala Ile Gly Met Phe Ala Asp Phe

245 250 255Ile Asp Asp Glu Gly Val Glu Leu Val Gly Ala Glu Pro Ala Gly Glu

260 265 270Gly Leu Asp Ser Gly Lys His Gly Ala Thr Ile Thr Asn Gly Gln Ile

275 280 285Gly Ile Leu His Gly Thr Arg Ser Tyr Leu Met Arg Asn Ser Asp Gly

290 295 300Gln Val Glu Glu Ser Tyr Ser Ile Ser Ala Gly Leu Asp Tyr Pro Gly305 310 315 320Val Gly Pro Gln His Ala His Leu His Ala Thr Gly Arg Ala Thr Tyr

325 330 335Val Gly Ile Thr Asp Ala Glu Ala Leu Gln Ala Phe Gln Tyr Leu Ala

340 345 350Arg Tyr Glu Gly Ile Ile Pro Ala Leu Glu Ser Ser His Ala Phe Ala

355 360 365Tyr Ala Leu Lys Arg Ala Lys Thr Ala Glu Val

370375<210>447<211>1231<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1231)<223>FRXA00956<400>447gccggtgcag gcacgtgggc tggggcgaaa gacgccggcg cgctgctgaa aattttagcg 60accatctcca cattccatta ctaaaggttt aaataggatc atg act gaa aaa gaa 115

Met Thr Glu Lys Glu

1 5aac ttg ggc ggc tcc acg ctg ctg cct gca tac ttc ggt gaa ttc ggc 163Asn Leu Gly Gly Ser Thr LeuLeu Pro Ala Tyr Phe Gly Glu Phe Gly

10 15 20ggc cag ttc gtc gcg gaa tcc ctc ctg cct gct ctc gac cag ctg gag 211Gly Gln Phe Val Ala Glu Ser Leu Leu Pro Ala Leu Asp Gln Leu Glu

25 30 35aag gcc ttc gtt gac gcg acc aac agc cca gag ttc cgc gaa gaa ctc 259Lys Ala Phe Val Asp Ala Thr Asn Ser Pro Glu Phe Arg Glu Glu Leu

40 45 50ggc ggc tac ctc cgc gat tac ctc ggc cgc cca acc ccg ctg acc gaa 307Gly Gly Tyr Leu Arg Asp Tyr Leu Gly Arg Pro Thr Pro Leu Thr Glu

55 60 65tgc tcc aac ctg cca ctc gca ggc gaa ggc aaa ggc ttt gcg cgg atc 355Cys Ser Asn Leu Pro Leu Ala Gly Glu Gly Lys Gly Phe Ala Arg Ile 70 75 80 85ttc ctc aag cgc gaa gac ctc gtc cac ggc ggt gca cac aaa act aac 403Phe Leu Lys Arg Glu Asp Leu Val His Gly Gly Ala His Lys Thr Asn

90 95 100cag gtg atc ggc cag gtg ctg ctt gcc aag cgc atg ggc aaa acc cgc 451Gln Val Ile Gly Gln Val Leu Leu Ala Lys Arg Met Gly Lys Thr Arg

105 110 115atc atc gca gag acc ggc gca ggc cag cac ggc acc gcc acc gct ctc 499Ile Ile Ala Glu Thr Gly Ala Gly Gln His Gly Thr Ala Thr Ala Leu

120 125 130gca tgt gcg ctc atg ggc ctc gag tgc gtt gtc tac atg ggc gcc aag 547Ala Cys Ala Leu Met Gly Leu Glu Cys Val Val Tyr Met Gly Ala Lys

135 140 145gac gtt gcc cgc cag cag ccc aac gtc tac cgc atg cag ctg cac ggc 595Asp Val Ala Arg Gln Gln Pro Asn Val Tyr Arg Met Gln Leu His Gly150 155 160165gcg aag gtc atc ccc gtg gaa tct ggt tcc ggc acc ctg aag gac gcc 643Ala Lys Val Ile Pro Val Glu Ser Gly Ser Gly Thr Leu Lys Asp Ala

170 175 180gtg aat gaa gcg ctg cgc gat tgg acc gca acc ttc cac gag tcc cac 691Val Asn Glu Ala Leu Arg Asp Trp Thr Ala Thr Phe His Glu Ser His

185 190 195tac ctt ctc ggc acc ccc gcc ggc ccg cac cca ttc cca acc atc gtg 739Tyr Leu Leu Gly Thr Pro Ala Gly Pro His Pro Phe Pro Thr Ile Val

200 205 210cgt gaa ttc cac aag gtg atc tct gag gaa gcc aag gca cag atg cta 787Arg Glu Phe His Lys Val Ile Ser Glu Glu Ala Lys Ala Gln Met Leu

215 220 225gag cgc acc ggc aag ctt ccc gac gtt gtg gtc gcc tgt gtc ggt ggt 835Glu Arg Thr Gly Lys Leu Pro Asp Val Val Val Ala Cys Val Gly Gly230 235 240 245ggc tcc aac gcc atc ggc atg ttc gca gac ttc att gac gat gaa ggt 883Gly Ser Asn Ala Ile Gly Met Phe Ala Asp Phe Ile Asp Asp Glu Gly

250 255 260gta gag ctc gtc ggc gct gag cca gcc ggt gaa ggc ctc gac tcc ggc 931Val Glu Leu Val Gly Ala Glu Pro Ala Gly Glu Gly Leu Asp Ser Gly

265 270 275aag cac ggc gca acc atc acc aac ggt cag atc ggc atc ctg cac ggc 979Lys His Gly Ala Thr Ile Thr Asn Gly Gln Ile Gly Ile Leu His Gly

280 285 290acc cgt tcc tac ctg atg cgc aac tcc gac ggc caa gtg gaa gag tcc 1027Thr Arg Ser Tyr Leu Met Arg Asn Ser Asp Gly Gln Val Glu Glu Ser

295 300 305tac tcc atc tcc gcc gga ctt gat tac cca ggc gtc ggc cca cag cac 1075Tyr Ser IleSer Ala Gly Leu Asp Tyr Pro Gly Val Gly Pro Gln His310 315 320 325gca cac ctg cac gcc acc ggc cgc gcc acc tac gtt ggt atc acc gac 1123Ala His Leu His Ala Thr Gly Arg Ala Thr Tyr Val Gly Ile Thr Asp

330 335 340gcc gaa gcc ctc caa gca ttc cag tac ctc gcc cgc tac gaa ggc atc 1171Ala Glu Ala Leu Gln Ala Phe Gln Tyr Leu Ala Arg Tyr Glu Gly Ile

345 350 355atc ccc gca ctg gaa tcc tca cac gcg ttc gcc tac gca ctc aag cgc 1219Ile Pro Ala Leu Glu Ser Ser His Ala Phe Ala Tyr Ala Leu Lys Arg

360 365 370gcc aag acc gcc 1231Ala Lys Thr Ala

375<210>448<211>377<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>448Met Thr Glu Lys Glu Asn Leu Gly Gly Ser Thr Leu Leu Pro Ala Tyr 151015 Phe Gly Glu Phe Gly Gly Gln Phe Val Ala Glu Ser Leu Leu Pro Ala

20 25 30Leu Asp Gln Leu Glu Lys Ala Phe Val Asp Ala Thr Asn Ser Pro Glu

35 40 45Phe Arg Glu Glu Leu Gly Gly Tyr Leu Arg Asp Tyr Leu Gly Arg Pro

50 55 60Thr Pro Leu Thr Glu Cys Ser Asn Leu Pro Leu Ala Gly Glu Gly Lys 65 70 75 80Gly Phe Ala Arg Ile Phe Leu Lys Arg Glu Asp Leu Val His Gly Gly

85 90 95Ala His Lys Thr Asn Gln Val Ile Gly Gln Val Leu Leu Ala Lys Arg

100 105 110Met Gly Lys Thr Arg Ile Ile Ala Glu Thr Gly Ala Gly Gln HisGly

115 120 125Thr Ala Thr Ala Leu Ala Cys Ala Leu Met Gly Leu Glu Cys Val Val

130 135 140Tyr Met Gly Ala Lys Asp Val Ala Arg Gln Gln Pro Asn Val Tyr Arg145 150 155 160Met Gln Leu His Gly Ala Lys Val Ile Pro Val Glu Ser Gly Ser Gly

165 170 175Thr Leu Lys Asp Ala Val Asn Glu Ala Leu Arg Asp Trp Thr Ala Thr

180 185 190Phe His Glu Ser His Tyr Leu Leu Gly Thr Pro Ala Gly Pro His Pro

195 200 205Phe Pro Thr Ile Val Arg Glu Phe His Lys Val Ile Ser Glu Glu Ala

210 215 220Lys Ala Gln Met Leu Glu Arg Thr Gly Lys Leu Pro Asp Val Val Val225 230 235 240Ala Cys Val Gly Gly Gly Ser Asn Ala Ile Gly Met Phe Ala Asp Phe

245 250 255Ile Asp Asp Glu Gly Val Glu Leu Val Gly Ala Glu Pro Ala Gly Glu

260 265 270Gly Leu Asp Ser Gly Lys His Gly Ala Thr Ile Thr Asn Gly Gln Ile

275 280 285Gly Ile Leu His Gly Thr Arg Ser Tyr Leu Met Arg Asn Ser Asp Gly

290 295 300Gln Val Glu Glu Ser Tyr Ser Ile Ser Ala Gly Leu Asp Tyr Pro Gly305 310 315 320Val Gly Pro Gln His Ala His Leu His Ala Thr Gly Arg Ala Thr Tyr

325 330 335Val Gly Ile Thr Asp Ala Glu Ala Leu Gln Ala Phe Gln Tyr Leu Ala

340 345 350Arg Tyr Glu Gly Ile Ile Pro Ala Leu Glu Ser Ser His Ala Phe Ala

355 360 365Tyr Ala Leu Lys Arg Ala Lys Thr Ala

370375<210>449<211>1401<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1378)<223>RXA00064<400>449tcccctaaaa cgtctagagt agtggcttga ggtcactgct ctttttttgt gccctttttt 60ggtccgtcta ttttgccacc acatgcggag gtacgcagtt atg agt tca gtt tcg 115

Met Ser Ser Val Ser

1 5ctg cag gat ttt gat gca gag cga att ggt ttg ttc cac gag gac att 163Leu Gln Asp Phe Asp Ala Glu Arg Ile Gly Leu Phe His Glu Asp Ile

10 15 20aag cgc aag ttt gat gag ctc aag tca aaa aat ctg aag ctg gat ctt 211Lys Arg Lys Phe Asp Glu Leu Lys Ser Lys Asn Leu Lys Leu Asp Leu

25 30 35act cgc ggt aag cct tcg tcg gag cag ttg gat ttc gct gat gag ttg 259Thr Arg Gly Lys Pro Ser Ser Glu Gln Leu Asp Phe Ala Asp Glu Leu

40 45 50ttg gcg ttg cct ggt aag ggt gat ttc aag gct gcg gat ggt act gat 307Leu Ala Leu Pro Gly Lys Gly Asp Phe Lys Ala Ala Asp Gly Thr Asp

55 60 65gtc cgt aac tat ggc ggg ctg gat ggc atc gtt gat att cgc cag att 355Val Arg Asn Tyr Gly Gly Leu Asp Gly Ile Val Asp Ile Arg Gln Ile 70 75 80 85tgg gcg gat ttg ctg ggt gtt cct gtg gag cag gtc ttg gcg ggg gat 403Trp Ala Asp Leu Leu Gly Val Pro Val Glu Gln Val Leu Ala Gly Asp

90 95 100gct tcg agc ttg aac atc atg ttt gat gtg atc agc tgg tcg tac att 451Ala Ser Ser Leu Asn Ile Met Phe Asp Val Ile Ser Trp Ser Tyr Ile

105 110 115ttc ggt aac aat gat tcg gtt cag cct tgg tcg aag gaa gaa acc gtt 499Phe Gly Asn Asn Asp Ser Val Gln Pro Trp Ser Lys Glu Glu Thr Val

120 125 130aag tgg att tgc cct gtt ccg ggc tat gat cgc cat ttc tcc atc acg 547Lys Trp Ile Cys Pro Val Pro Gly Tyr Asp Arg His Phe Ser Ile Thr

135 140 145gag cgt ttc ggc ttt gag atg att tct gtg cca atg aat gaa gac ggc 595Glu Arg Phe Gly Phe Glu Met Ile Ser Val Pro Met Asn Glu Asp Gly150 155 160 165cct gat atg gat gct gtt gag gaa ttg gtg aag aat ccg cag gtt aag 643Pro Asp Met Asp Ala Val Glu Glu Leu Val Lys Asn Pro Gln Val Lys

170 175 180ggc atg tgg gtt gtt ccg gtg ttt tct aac ccg act ggt ttc acg gtg 691Gly Met Trp Val Val Pro Val Phe Ser Asn Pro Thr Gly Phe Thr Val

185 190 195aca gaa gac gtc gca aag cgt cta agc gca atg gaa acc gca gct ccg 739Thr Glu Asp Val Ala Lys Arg Leu Ser Ala Met Glu Thr Ala Ala Pro

200 205 210gac ttc cgc gtt gtg tgg gat aat gcc tac gcc gtt cat acg ctg acc 787Asp Phe Arg Val Val Trp Asp Asn Ala Tyr Ala Val His Thr Leu Thr

215 220 225gat gaa ttc cct gag gtt atc gat atc gtc ggg ctt ggt gag gcc gct 835Asp Glu Phe Pro Glu Val Ile Asp Ile Val Gly Leu Gly Glu Ala Ala230 235 240 245ggc aac ccg aac cgtttc tgg gcg ttc act tct act tcg aag atc act 883Gly Asn Pro Asn Arg Phe Trp Ala Phe Thr Ser Thr Ser Lys Ile Thr

250 255 260ctc gcg ggt gcg ggc gtg tcg ttc ttc ctc acc tct gcg gag aac cgc 931Leu Ala Gly Ala Gly Val Ser Phe Phe Leu Thr Ser Ala Glu Asn Arg

265 270 275aag tgg tac acc ggc cat gcg ggt atc cgt ggc att ggc cct aac aag 979Lys Trp Tyr Thr Gly His Ala Gly Ile Arg Gly Ile Gly Pro Asn Lys

280 285 290gtc aat cag ttg gct cat gcg cgt tac ttt ggc gat gct gag gga gtg 1027Val Asn Gln Leu Ala His Ala Arg Tyr Phe Gly Asp Ala Glu Gly Val

295 300 305cgc gcg gtg atg cgt aag cat gct gcg tcg ttg gct ccg aag ttc aac 1075Arg Ala Val Met Arg Lys His Ala Ala Ser Leu Ala Pro Lys Phe Asn310 315 320 325aag gtt ctg gag att ctg gat tct cgc ctt gct gag tac ggt gtc gcg 1123Lys Val Leu Glu Ile Leu Asp Ser Arg Leu Ala Glu Tyr Gly Val Ala

330 335 340cag tgg act gtc cct gcg ggc ggt tac ttc att tcc ctt gat gtg gtt 1171Gln Trp Thr Val Pro Ala Gly Gly Tyr Phe Ile Ser Leu Asp Val Val

345 350 355cct ggt acg gcg tct cgc gtg gct gag ttg gct aag gaa gcc ggc atc 1219Pro Gly Thr Ala Ser Arg Val Ala Glu Leu Ala Lys Glu Ala Gly Ile

360 365 370gcg ttg acg ggt gcg ggt tct tct tac ccg ctg cgt cag gat ccg gag 1267Ala Leu Thr Gly Ala Gly Ser Ser Tyr Pro Leu Arg Gln Asp Pro Glu

375 380 385aac aaa aat ctc cgt ttg gca ccg tcg ctg cct cca gtt gag gaa ctt 1315Asn Lys Asn Leu Arg Leu AlaPro Ser Leu Pro Pro Val Glu Glu Leu390 395 400 405gag gtt gcc atg gat ggc gtg gct acc tgt gtg ctg ttg gca gca gcg 1363Glu Val Ala Met Asp Gly Val Ala Thr Cys Val Leu Leu Ala Ala Ala

410 415 420gag cat tac gct aac taaaagtgaa tacagcggag aca 1401Glu His Tyr Ala Asn

425<210>450<211>426<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>450Met Ser Ser Val Ser Leu Gln Asp Phe Asp Ala Glu Arg Ile Gly Leu 151015 Phe His Glu Asp Ile Lys Arg Lys Phe Asp Glu Leu Lys Ser Lys Asn

20 25 30Leu Lys Leu Asp Leu Thr Arg Gly Lys Pro Ser Ser Glu Gln Leu Asp

35 40 45Phe Ala Asp Glu Leu Leu Ala Leu Pro Gly Lys Gly Asp Phe Lys Ala

50 55 60Ala Asp Gly Thr Asp Val Arg Asn Tyr Gly Gly Leu Asp Gly Ile Val 65 70 75 80Asp Ile Arg Gln Ile Trp Ala Asp Leu Leu Gly Val Pro Val Glu Gln

85 90 95Val Leu Ala Gly Asp Ala Ser Ser Leu Asn Ile Met Phe Asp Val Ile

100 105 110Ser Trp Ser Tyr Ile Phe Gly Asn Asn Asp Ser Val Gln Pro Trp Ser

115 120 125Lys Glu Glu Thr Val Lys Trp Ile Cys Pro Val Pro Gly Tyr Asp Arg

130 135 140His Phe Ser Ile Thr Glu Arg Phe Gly Phe Glu Met Ile Ser Val Pro145 150 155 160Met Asn Glu Asp Gly Pro Asp Met Asp Ala Val Glu Glu Leu Val Lys

165 170 175Asn Pro Gln Val Lys Gly Met Trp Val Val Pro Val Phe Ser Asn Pro

180 185 190Thr Gly Phe Thr Val Thr Glu Asp Val Ala Lys Arg Leu Ser Ala Met

195 200 205Glu Thr Ala Ala Pro Asp Phe Arg Val Val Trp Asp Asn Ala Tyr Ala

210 215 220Val His Thr Leu Thr Asp Glu Phe Pro Glu Val Ile Asp Ile Val Gly225 230 235 240Leu Gly Glu Ala Ala Gly Asn Pro Asn Arg Phe Trp Ala Phe Thr Ser

245 250 255Thr Ser Lys Ile Thr Leu Ala Gly Ala Gly Val Ser Phe Phe Leu Thr

260 265 270Ser Ala Glu Asn Arg Lys Trp Tyr Thr Gly His Ala Gly Ile Arg Gly

275 280 285Ile Gly Pro Asn Lys Val Asn Gln Leu Ala His Ala Arg Tyr Phe Gly

290 295 300Asp Ala Glu Gly Val Arg Ala Val Met Arg Lys His Ala Ala Ser Leu305 310 315 320Ala Pro Lys Phe Asn Lys Val Leu Glu Ile Leu Asp Ser Arg Leu Ala

325 330 335Glu Tyr Gly Val Ala Gln Trp Thr Val Pro Ala Gly Gly Tyr Phe Ile

340 345 350Ser Leu Asp Val Val Pro Gly Thr Ala Ser Arg Val Ala Glu Leu Ala

355 360 365Lys Glu Ala Gly Ile Ala Leu Thr Gly Ala Gly Ser Ser Tyr Pro Leu

370 375 380Arg Gln Asp Pro Glu Asn Lys Asn Leu Arg Leu Ala Pro Ser Leu Pro385 390 395 400Pro Val Glu Glu Leu Glu Val Ala Met Asp Gly Val Ala Thr Cys Val

405 410 415Leu Leu Ala Ala Ala Glu His Tyr Ala Asn

420425<210>451<211>1143<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1120)<223>RXN00448<400>451ccatttacct tcaactaagg tagccgtaac tgcaaagctc aggccatcct cttcagtgtt 60catagagata accgtagtag gtatgtgcca cacttgtcag gtg act acc aaa gac 115

Val Thr Thr Lys Asp

1 5att tcc cgc cca gta tgc atc ctg ggc ctc ggc ctc atc ggc gga tcc 163Ile Ser Arg Pro Val Cys Ile Leu Gly Leu Gly Leu Ile Gly Gly Ser

10 15 20ctc ctc cgc gac ctc cat gca gcc aac cac tcc gtc ttc ggc tac aac 211Leu Leu Arg Asp Leu His Ala Ala Asn His Ser Val Phe Gly Tyr Asn

25 30 35cgc tca cgc tcc ggc gct aaa tca gcc gtc gac gaa ggc ttc gac gtt 259Arg Ser Arg Ser Gly Ala Lys Ser Ala Val Asp Glu Gly Phe Asp Val

40 45 50tcc gcc gat ctt gaa gca acc ctc cag cgt gca gcc gcc gaa gat gcg 307Ser Ala Asp Leu Glu Ala Thr Leu Gln Arg Ala Ala Ala Glu Asp Ala

55 60 65ctc atc gtc ctc gcg gtc ccc atg acc gca atc gat tcg ctt ctc gac 355Leu Ile Val Leu Ala Val Pro Met Thr Ala Ile Asp Ser Leu Leu Asp 70 75 80 85gcc gtc cac acc cac gca cca aac aac ggc ttc acc gac gtc gta tcc 403Ala Val His Thr His Ala Pro Asn Asn Gly Phe Thr Asp Val Val Ser

90 95 100gta aaa acc gcc gtc tac gac gca gta aaa gcc cgc aac atg caa cac 451Val Lys Thr Ala Val Tyr Asp Ala Val Lys Ala Arg Asn Met Gln His

105 110 115cgt tat gtg gga tcc cac ccc atg gca ggc acc gcc aac tcc ggc tgg 499Arg Tyr Val Gly Ser His Pro Met Ala Gly Thr Ala Asn Ser Gly Trp

120 125 130agc gca tcc atg gac gga ctg ttc aaa cga gca gta tgg gtg gtc acc 547Ser Ala Ser Met Asp Gly Leu Phe Lys Arg Ala Val Trp Val Val Thr

135 140 145ttc gac cag ctt ttc gac ggc acc gac atc aac tcc acc tgg atc agc 595Phe Asp Gln Leu Phe Asp Gly Thr Asp Ile Asn Ser Thr Trp Ile Ser150 155 160 165atc tgg aaa gac gtc gtc caa atg gca ctc gcc gtg ggc gct gaa gtt 643Ile Trp Lys Asp Val Val Gln Met Ala Leu Ala Val Gly Ala Glu Val

170 l75 180gtc cca tcc cga gtt ggc cca cac gat gca gca gca gca cga gtg tct 691Val Pro Ser Arg Val Gly Pro His Asp Ala Ala Ala Ala Arg Val Ser

185 190 195cat tta aca cac atc ctg gct gaa acc ctc gcc atc gtc ggt gac aac 739His Leu Thr His Ile Leu Ala Glu Thr Leu Ala Ile Val Gly Asp Asn

200 205 210ggt ggc gca ctg tct ctc tct tta gcc gct ggc agc tac cgc gac tcc 787Gly Gly Ala Leu Ser Leu Ser Leu Ala Ala Gly Ser Tyr Arg Asp Ser

215 220 225acc cgc gtt gca ggc acc gac cca gga ctc gtc cgc gcc atg tgt gaa 835Thr Arg Val Ala Gly Thr Asp Pro Gly Leu Val Arg Ala Met Cys Glu230 235 240 245agc aac gcc ggc cca ctg gtc aaa gcc ctc gac gaa gca ctg gcg atc 883Ser Asn Ala Gly Pro Leu Val Lys Ala Leu Asp Glu Ala Leu Ala Ile

250 255 260ctc cac gaa gcc cgc gaa ggc ctc acc gca gaa cag cca aac atc gag 931Leu His Glu Ala Arg Glu Gly Leu Thr Ala Glu Gln Pro Asn Ile Glu

265 270 275caa ctt gcc gac aac ggc tac cga tcc cgc atc cgc tac gaa gcc cgc 979Gln Leu Ala Asp Asn Gly Tyr Arg Ser Arg Ile Arg Tyr Glu Ala Arg

280 285 290tcc ggc cag cga cgc gcc aaa gaa tcc gtt agc cct acc atc acc tca 1027Ser Gly Gln Arg Arg Ala Lys Glu Ser Val Ser Pro Thr Ile Thr Ser

295 300 305tcc agg cca gtg ctc cgt ctc cac ccg ggc aca cca aac tgg gag aag 1075Ser Arg Pro Val Leu Arg Leu His Pro Gly Thr Pro Asn Trp Glu Lys310 315 320 325cag ctc atc cac gct gaa acc ctc ggc gca cgg atc gaa gtg ttc 1120Gln Leu Ile His Ala Glu Thr Leu Gly Ala Arg Ile Glu Val Phe

330335340 tagttttatc ggctgatgat tct 1143<210>452<211>340<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>452Val Thr Thr Lys Asp Ile Ser Arg Pro Val Cys Ile Leu Gly Leu Gly 151015 Leu Ile Gly Gly Ser Leu Leu Arg Asp Leu His Ala Ala Asn His Ser

20 25 30Val Phe Gly Tyr Asn Arg Ser Arg Ser Gly Ala Lys Ser Ala Val Asp

35 40 45Glu Gly Phe Asp Val Ser Ala Asp Leu Glu Ala Thr Leu Gln Arg Ala

50 55 60Ala Ala Glu Asp Ala Leu Ile Val Leu Ala Val Pro Met Thr Ala Ile 65 70 7580Asp Ser Leu Leu Asp Ala Val His Thr His Ala Pro Asn Asn Gly Phe

85 90 95Thr Asp Val Val Ser Val Lys Thr Ala Val Tyr Asp Ala Val Lys Ala

100 105 110Arg Asn Met Gln His Arg Tyr Val Gly Ser His Pro Met Ala Gly Thr

115 120 125Ala Asn Ser Gly Trp Ser Ala Ser Met Asp Gly Leu Phe Lys Arg Ala

130 135 140Val Trp Val Val Thr Phe Asp Gln Leu Phe Asp Gly Thr Asp Ile Asn145 150 155 160Ser Thr Trp Ile Ser Ile Trp Lys Asp Val Val Gln Met Ala Leu Ala

165 170 175Val Gly Ala Glu Val Val Pro Ser Arg Val Gly Pro His Asp Ala Ala

180 185 190Ala Ala Arg Val Ser His Leu Thr His Ile Leu Ala Glu Thr Leu Ala

195 200 205Ile Val Gly Asp Asn Gly Gly Ala Leu Ser Leu Ser Leu Ala Ala Gly

210 215 220Ser Tyr Arg Asp Ser Thr Arg Val Ala Gly Thr Asp Pro Gly Leu Val225 230 235 240Arg Ala Met Cys Glu Ser Asn Ala Gly Pro Leu Val Lys Ala Leu Asp

245 250 255Glu Ala Leu Ala Ile Leu His Glu Ala Arg Glu Gly Leu Thr Ala Glu

260 265 270Gln Pro Asn Ile Glu Gln Leu Ala Asp Asn Gly Tyr Arg Ser Arg Ile

275 280 285Arg Tyr Glu Ala Arg Ser Gly Gln Arg Arg Ala Lys Glu Ser Val Ser

290295 300Pro Thr Ile Thr Ser Ser Arg Pro Val Leu Arg Leu His Pro Gly Thr305 310 315 320Pro Asn Trp Glu Lys Gln Leu Ile His Ala Glu Thr Leu Gly Ala Arg

325 330 335Ile Glu Val Phe

340<210>453<211>689<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (666)<223>FRXA00448<400>453tat gtg gga tcc cac ccc atg gca ggc acc gcc aac tcc ggc tgg agc 48Tyr Val Gly Ser His Pro Met Ala Gly Thr Ala Asn Ser Gly Trp Ser 151015 gca tcc atg gac gga ctg ttc aaa cga gca gta tgg gtg gtc acc ttc 96Ala Ser Met Asp Gly Leu Phe Lys Arg Ala Val Trp Val Val Thr Phe

20 25 30gac cag ctt ttc gac ggc acc gac atc aac tcc acc tgg atc agc atc 144Asp Gln Leu Phe Asp Gly Thr Asp Ile Asn Ser Thr Trp Ile Ser Ile

35 40 45tgg aaa gac gtc gtc caa atg gca ctc gcc gtg ggc gct gaa gtt gtc 192Trp Lys Asp Val Val Gln Met Ala Leu Ala Val Gly Ala Glu Val Val

50 55 60cca tcc cga gtt ggc cca cac gat gca gca gca gca cga gtg tct cat 240Pro Ser Arg Val Gly Pro His Asp Ala Ala Ala Ala Arg Val Ser His 65 70 75 80tta aca cac atc ctg gct gaa acc ctc gcc atc gtc ggt gac aac ggt 288Leu Thr His Ile Leu Ala Glu Thr Leu Ala Ile Val Gly Asp Asn Gly

85 90 95ggc gca ctg tct ctc tct tta gcc gct ggc agc tac cgc gac tcc acc 336Gly Ala Leu Ser Leu Ser Leu Ala Ala Gly Ser Tyr Arg Asp Ser Thr

100 105 110cgc gtt gca ggc acc gaccca gga ctc gtc cgc gcc atg tgt gaa agc 384Arg Val Ala Gly Thr Asp Pro Gly Leu Val Arg Ala Met Cys Glu Ser

115 120 125aac gcc ggc cca ctg gtc aaa gcc ctc gac gaa gca ctg gcg atc ctc 432Asn Ala Gly Pro Leu Val Lys Ala Leu Asp Glu Ala Leu Ala Ile Leu

130 135 140cac gaa gcc cgc gaa ggc ctc acc gca gaa cag cca aac atc gag caa 480His Glu Ala Arg Glu Gly Leu Thr Ala Glu Gln Pro Asn Ile Glu Gln145 150 155 160ctt gcc gac aac ggc tac cga tcc cgc atc cgc tac gaa gcc cgc tcc 528Leu Ala Asp Asn Gly Tyr Arg Ser Arg Ile Arg Tyr Glu Ala Arg Ser

165 170 175ggc cag cga cgc gcc aaa gaa tcc gtt agc cct acc atc acc tca tcc 576Gly Gln Arg Arg Ala Lys Glu Ser Val Ser Pro Thr Ile Thr Ser Ser

180 185 190agg cca gtg ctc cgt ctc cac ccg ggc aca cca aac tgg gag aag cag 624Arg Pro Val Leu Arg Leu His Pro Gly Thr Pro Asn Trp Glu Lys Gln

195 200 205ctc atc cac gct gaa acc ctc ggc gca cgg atc gaa gtg ttc 666Leu Ile His Ala Glu Thr Leu Gly Ala Arg Ile Glu Val Phe

210215220 tagttttatc ggctgatgat tct 689<210>454<211>222<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>454Tyr Val Gly Ser His Pro Met Ala Gly Thr Ala Asn Ser Gly Trp Ser 151015 Ala Ser Met Asp Gly Leu Phe Lys Arg Ala Val Trp Val Val Thr Phe

20 25 30Asp Gln Leu Phe Asp Gly Thr Asp Ile Asn Ser Thr Trp Ile Ser Ile

35 40 45Trp Lys Asp Val Val Gln Met Ala Leu Ala Val Gly Ala Glu Val Val

50 55 60Pro Ser Arg Val Gly Pro His Asp Ala Ala Ala Ala Arg Val Ser His 65 70 75 80Leu Thr His Ile Leu Ala Glu Thr Leu Ala Ile Val Gly Asp Asn Gly

85 90 95Gly Ala Leu Ser Leu Ser Leu Ala Ala Gly Ser Tyr Arg Asp Ser Thr

100 105 110Arg Val Ala Gly Thr Asp Pro Gly Leu Val Arg Ala Met Cys Glu Ser

115 120 125Asn Ala Gly Pro Leu Val Lys Ala Leu Asp Glu Ala Leu Ala Ile Leu

130 135 140His Glu Ala Arg Glu Gly Leu Thr Ala Glu Gln Pro Asn Ile Glu Gln145 150 155 160Leu Ala Asp Asn Gly Tyr Arg Ser Arg Ile Arg Tyr Glu Ala Arg Ser

165 170 175Gly Gln Arg Arg Ala Lys Glu Ser Val Ser Pro Thr Ile Thr Ser Ser

180 185 190Arg Pro Val Leu Arg Leu His Pro Gly Thr Pro Asn Trp Glu Lys Gln

195 200 205Leu Ile His Ala Glu Thr Leu Gly Ala Arg Ile Glu Val Phe

210215220<210>455<211>346<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (346)<223>FRXA00452<400>455ccatttacct tcaactaagg tagccgtaac tgcaaagctc aggccatcct cttcagtgtt 60catagagata accgtagtag gtatgtgcca cacttgtcag gtg act acc aaa gac 115

Val Thr Thr Lys Asp

1 5att tcc cgc cca gta tgc atc ctg ggc ctc ggc ctc atc ggc gga tcc 163Ile Ser Arg Pro Val Cys Ile Leu Gly Leu Gly Leu Ile Gly Gly Ser

10 15 20ctc ctc cgc gac ctc cat gca gcc aac cac tcc gtc ttc ggc tac aac 211Leu Leu Arg Asp Leu His Ala Ala Asn His Ser Val Phe Gly Tyr Asn

25 30 35cgc tca cgc tcc ggc gct aaa tca gcc gtc gac gaa ggc ttc gac gtt 259Arg Ser Arg Ser Gly Ala Lys Ser Ala Val Asp Glu Gly Phe Asp Val

40 45 50tcc gcc gat ctt gaa gca acc ctc cag cgt gca gcc gcc gaa gat gcg 307Ser Ala Asp Leu Glu Ala Thr Leu Gln Arg Ala Ala Ala Glu Asp Ala

556065 ctc atc gtc ctc gcg gtc ccc atg acc gca atc gat tcg 346Leu Ile Val Leu Ala Val Pro Met Thr Ala Ile Asp Ser 707580<210>456<211>82<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>456Val Thr Thr Lys Asp Ile Ser Arg Pro Val Cys Ile Leu Gly Leu Gly 151015 Leu Ile Gly Gly Ser Leu Leu Arg Asp Leu His Ala Ala Asn His Ser

20 25 30Val Phe Gly Tyr Asn Arg Ser Arg Ser Gly Ala Lys Ser Ala Val Asp

35 40 45Glu Gly Phe Asp Val Ser Ala Asp Leu Glu Ala Thr Leu Gln Arg Ala

505560 Ala Ala Glu Asp Ala Leu Ile Val Leu Ala Val Pro Met Thr Ala Ile 65707580 Asp Ser<210>457<211>1248<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1225)<223>RXA00584<400>457tagttgtgcc acctaaaacg cgaacagaac cggagtcgag cagcacctcc ccgcaagggt 60agaggggctg cttttttgtt tcctaaattc accccatccc atg cat agc cct gaa 115

Met His Ser Pro Glu

1 5agg caa gaa aaa atg agt tct cca gtc tca ctc gaa aac gcg gcg tca 163Arg Gln Glu Lys Met Ser Ser Pro Val Ser Leu Glu Asn Ala Ala Ser

10 15 20acc agc aac aag cgc gtc gtg gct ttc cac gag ctg cct agc cct aca 211Thr Ser Asn Lys Arg Val Val Ala Phe His Glu Leu Pro Ser Pro Thr

25 30 35gat ctc atc gcc gca aac cca ctg aca cca aag cag gct tcc aag gtg 259Asp Leu Ile Ala Ala Asn Pro Leu Thr Pro Lys Gln Ala Ser Lys Val

40 45 50gag cag gat cgc cag gac atc gct gat atc ttc gct ggc gac gat gac 307Glu Gln Asp Arg Gln Asp Ile Ala Asp Ile Phe Ala Gly Asp Asp Asp

55 60 65cgc ctc gtt gtc gtt gtg gga cct tgc tca gtt cac gat cct gaa gca 355Arg Leu Val Val Val Val Gly Pro Cys Ser Val His Asp Pro Glu Ala 70 75 80 85gcc atc gat tac gca aac cgc ctg gct ccg ctg gca aag cgc ctt gat 403Ala Ile Asp Tyr Ala Asn Arg Leu Ala Pro Leu Ala Lys Arg Leu Asp

90 95 100cag gac ctc aag att gtc atg cgc gtg tac ttc gag aag cct cgc acc 451Gln Asp Leu Lys Ile Val Met Arg Val Tyr Phe Glu Lys Pro Arg Thr

105 110 115atc gtc gga tgg aag gga ttg atc aat gat cct cac ctc aac gaa acc 499Ile Val Gly Trp Lys Gly Leu Ile Asn Asp Pro His Leu Asn Glu Thr

120 125 130tac gac atc cca gag ggc ttg cgc att gcg cgc aaa gtg ctt atc gac 547Tyr Asp Ile Pro Glu Gly Leu Arg Ile Ala Arg Lys Val Leu Ile Asp

135 140 145gtt gtg aac ctt gat ctc cca gtc ggc tgc gaa ttc ctc gaa cca aac 595Val Val Asn Leu Asp Leu Pro Val Gly Cys Glu Phe Leu Glu Pro Asn150 155 160 165agc cct cag tac tac gcc gac act gtc gca tgg gga gca atc ggc gct 643Ser Pro Gln Tyr Tyr Ala Asp Thr Val Ala Trp Gly Ala Ile Gly Ala

170 175 180cgt acc acc gaa tct cag gtg cac cgc cag ctg gct tct ggg atg tct 691Arg Thr Thr Glu Ser Gln Val His Arg Gln Leu Ala Ser Gly Met Ser

185 190 195atg cca att ggt ttc aag aac gga act gac gga aac atc cag gtt gca 739Met Pro Ile Gly Phe Lys Asn Gly Thr Asp Gly Asn Ile Gln Val Ala

200 205 210gtc gac gcg gta cag gct gcc cag aac cca cac ttc ttc ttc gga acc 787Val Asp Ala Val Gln Ala Ala Gln Asn Pro His Phe Phe Phe Gly Thr

215 220 225tcc gac gac ggc gcg ctg agc gtc gtg gag acc gca ggc aac agc aac 835Ser Asp Asp Gly Ala Leu Ser Val Val Glu Thr Ala Gly Asn Ser Asn230 235 240 245tcc cac atc att ttg cgc ggc ggt acc tcc ggc ccg aat cat gat gca 883Ser His Ile Ile Leu Arg Gly Gly Thr Ser Gly Pro Asn His Asp Ala

250 255 260gct tcg gtg gag gcc gtc gtc gag aag ctt ggt gaa aac gct cgt ctc 931Ala Ser Val Glu Ala Val Val Glu Lys Leu Gly Glu Asn Ala Arg Leu

265 270 275atg atc gat gct tcc cat gct aac tcc ggc aag gat cat atc cga cag 979Met Ile Asp Ala Ser His Ala Asn Ser Gly Lys Asp His Ile Arg Gln

280 285 290gtt gag gtt gtt cgt gaa atc gca gagcag att tct ggc ggt tct gaa 1027Val Glu Val Val Arg Glu Ile Ala Glu Gln Ile Ser Gly Gly Ser Glu

295 300 305gct gtg gct gga atc atg att gag tcc ttc ctc gtt ggt ggc gca cag 1075Ala Val Ala Gly Ile Met Ile Glu Ser Phe Leu Val Gly Gly Ala Gln310 315 320 325aac ctt gat cct gcg aaa ttg cgc atc aat ggc ggt gaa ggc ctg gtg 1123Asn Leu Asp Pro Ala Lys Leu Arg Ile Asn Gly Gly Glu Gly Leu Val

330 335 340tac gga cag tct gtg acc gat aag tgc atc gat att gac acc acc atc 1171Tyr Gly Gln Ser Val Thr Asp Lys Cys Ile Asp Ile Asp Thr Thr Ile

345 350 355gat ttg ctc gct gag ctg gcc gca gca gta agg gaa cgc cga gca gca 1219Asp Leu Leu Ala Glu Leu Ala Ala Ala Val Arg Glu Arg Arg Ala Ala

360 365 370gcc aag taattaaggg cgctagactg tta 1248Ala Lys

375<210>458<211>375<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>458Met His Ser Pro Glu Arg Gln Glu Lys Met Ser Ser Pro Val Ser Leu 151015 Glu Asn Ala Ala Ser Thr Ser Asn Lys Arg Val Val Ala Phe His Glu

20 25 30Leu Pro Ser Pro Thr Asp Leu Ile Ala Ala Asn Pro Leu Thr Pro Lys

35 40 45Gln Ala Ser Lys Val Glu Gln Asp Arg Gln Asp Ile Ala Asp Ile Phe

50 55 60Ala Gly Asp Asp Asp Arg Leu Val Val Val Val Gly Pro Cys Ser Val 65 70 75 80His Asp Pro Glu Ala Ala Ile Asp Tyr Ala Asn Arg Leu Ala Pro Leu

85 90 95Ala Lys Arg Leu Asp Gln Asp Leu Lys Ile Val Met Arg Val Tyr Phe

100 105 110Glu Lys Pro Arg Thr Ile Val Gly Trp Lys Gly Leu Ile Asn Asp Pro

115 120 125His Leu Asn Glu Thr Tyr Asp Ile Pro Glu Gly Leu Arg Ile Ala Arg

130 135 140Lys Val Leu Ile Asp Val Val Asn Leu Asp Leu Pro Val Gly Cys Glu145 150 155 160Phe Leu Glu Pro Asn Ser Pro Gln Tyr Tyr Ala Asp Thr Val Ala Trp

165 170 175Gly Ala Ile Gly Ala Arg Thr Thr Glu Ser Gln Val His Arg Gln Leu

180 185 190Ala Ser Gly Met Ser Met Pro Ile Gly Phe Lys Asn Gly Thr Asp Gly

195 200 205Asn Ile Gln Val Ala Val Asp Ala Val Gln Ala Ala Gln Asn Pro His

210 215 220Phe Phe Phe Gly Thr Ser Asp Asp Gly Ala Leu Ser Val Val Glu Thr225 230 235 240Ala Gly Asn Ser Asn Ser His Ile Ile Leu Arg Gly Gly Thr Ser Gly

245 250 255Pro Asn His Asp Ala Ala Ser Val Glu Ala Val Val Glu Lys Leu Gly

260 265 270Glu Asn Ala Arg Leu Met Ile Asp Ala Ser His Ala Asn Ser Gly Lys

275 280 285Asp His Ile Arg Gln Val Glu Val Val Arg Glu Ile Ala Glu Gln Ile

290 295 300Ser Gly Gly Ser Glu Ala Val Ala Gly Ile Met Ile Glu Ser Phe Leu305310 315 320Val Gly Gly Ala Gln Asn Leu Asp Pro Ala Lys Leu Arg Ile Asn Gly

325 330 335Gly Glu Gly Leu Val Tyr Gly Gln Ser Val Thr Asp Lys Cys Ile Asp

340 345 350Ile Asp Thr Thr Ile Asp Leu Leu Ala Glu Leu Ala Ala Ala Val Arg

355 360 365Glu Arg Arg Ala Ala Ala Lys

370375<210>459<211>1983<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1960)<223>RXA00579<400>459tcgtctaagt ttttctttga gttttcatat gtagaaggca tcgtcggctt cggcctggcg 60gtgcttttct cgttgttttg tggttttgtc agaggatgtc atg cgc gtt tta att 115

Met Arg Val Leu Ile

1 5att gat aat tat gat tct ttc acg ttt aat ctc gcc acc tat gtg gaa 163Ile Asp Asn Tyr Asp Ser Phe Thr Phe Asn Leu Ala Thr Tyr Val Glu

10 15 20gag gtt acg ggt cag gca cct gtg gtg gtg cct aat gat caa gaa ata 211Glu Val Thr Gly Gln Ala Pro Val Val Val Pro Asn Asp Gln Glu Ile

25 30 35gat gag atg ctt ttc gac gcc gtc atc ctc tca cct ggc ccg ggc cac 259Asp Glu Met Leu Phe Asp Ala Val Ile Leu Ser Pro Gly Pro Gly His

40 45 50gcc ggc gtt gcg gct gat ttt ggt atc tgt gca ggc gtc att gag cgt 307Ala Gly Val Ala Ala Asp Phe Gly Ile Cys Ala Gly Val Ile Glu Arg

55 60 65gca cgc gtt ccg att ttg ggt gtg tgt tta ggccac cag ggc att gcg 355Ala Arg Val Pro Ile Leu Gly Val Cys Leu Gly His Gln Gly Ile Ala 70 75 80 85ttg gcc tat ggc ggt gat gtt gat ttg gcg ccc agg ccg gtc cac ggt 403Leu Ala Tyr Gly Gly Asp Val Asp Leu Ala Pro Arg Pro Val His Gly

90 95 100gag gtt tcg cag atc acc cat gat ggt tca ggt tta ttt gca ggc atc 451Glu Val Ser Gln Ile Thr His Asp Gly Ser Gly Leu Phe Ala Gly Ile

105 110 115cct gaa acg ttt gag gcg gtg cgt tat cac tcg atg gtg gca acc cgc 499Pro Glu Thr Phe Glu Ala Val Arg Tyr His Ser Met Val Ala Thr Arg

120 125 130ttg ccg gag tca ttg aaa gct aca gct acc agc gat gat ggt ttg atc 547Leu Pro Glu Ser Leu Lys Ala Thr Ala Thr Ser Asp Asp Gly Leu Ile

135 140 145atg gca ttg gca cat gaa gtg ctt ccg cag tgg ggt gtg caa ttt cat 595Met Ala Leu Ala His Glu Val Leu Pro Gln Trp Gly Val Gln Phe His150 155 160 165ccg gaa tct att ggt gga caa ttc ggc cat cag atc att aag aac ttc 643Pro Glu Ser Ile Gly Gly Gln Phe Gly His Gln Ile Ile Lys Asn Phe

170 175 180ctt aat tta gcg cgc aca tat cgc tgg caa ctc acg gag aaa act att 691Leu Asn Leu Ala Arg Thr Tyr Arg Trp Gln Leu Thr Glu Lys Thr Ile

185 190 195ccg ctc agc gtt gat tca gca gcg gtt ttt gaa aca ttc ttt gcc cat 739Pro Leu Ser Val Asp Ser Ala Ala Val Phe Glu Thr Phe Phe Ala His

200 205 210tcc tcc cat gct ttt tgg ctc gat gat gcc caa gga acc agc tat ctt 787Ser Ser His Ala Phe Trp Leu Asp Asp Ala Gln Gly Thr Ser Tyr Leu

215 220 225ggt gat gcc agc ggt cct ctc gca cgc aca aaa acc cat aat gtc ggc 835Gly Asp Ala Ser Gly Pro Leu Ala Arg Thr Lys Thr His Asn Val Gly230 235 240 245gag ggg gat ttc ttc acc tgg cta aag gag gat ctc gcc gcc aac tca 883Glu Gly Asp Phe Phe Thr Trp Leu Lys Glu Asp Leu Ala Ala Asn Ser

250 255 260gtt gcg ccc ggt caa ggt ttt cgt ctt ggc tgg gtt ggt tac gtt ggt 931Val Ala Pro Gly Gln Gly Phe Arg Leu Gly Trp Val Gly Tyr Val Gly

265 270 275tat gag ctt aaa gcg gaa gct ggc gca cgg gct gcg cac act tcg agt 979Tyr Glu Leu Lys Ala Glu Ala Gly Ala Arg Ala Ala His Thr Ser Ser

280 285 290ctt ccg gat gcg cac ctc att ttt gcc gat cgc gcc atc gca gtg gaa 1027Leu Pro Asp Ala His Leu Ile Phe Ala Asp Arg Ala Ile Ala Val Glu

295 300 305tcg gat cag gtt cgg ttg ctg gcg ttg ggg gag cag gac gag tgg ttt 1075Ser Asp Gln Val Arg Leu Leu Ala Leu Gly Glu Gln Asp Glu Trp Phe310 315 320 325gaa gaa acc atc aag aag ctg cat aat ctt gtc gcc ccg cgg ata cct 1123Glu Glu Thr Ile Lys Lys Leu His Asn Leu Val Ala Pro Arg Ile Pro

330 335 340gcg tcc gga cac ctc gct ttg cag gtt cga gat tcc aaa gat gag tat 1171Ala Ser Gly His Leu Ala Leu Gln Val Arg Asp Ser Lys Asp Glu Tyr

345 350 355ctc gac aaa att cgc aga gcc cag gag ctg att act cgc ggc gaa tcg 1219Leu Asp Lys Ile Arg Arg Ala Gln Glu Leu Ile Thr Arg Gly Glu Ser

360 365 370tat gaa atc tgc ctg acc aca aaa ctt cag ggc acc act gat gtg gcc 1267Tyr Glu Ile Cys Leu Thr Thr Lys Leu Gln Gly Thr Thr Asp Val Ala

375 380 385cct ctg gct gcc tat cta gca ctg cgt ggg gcc aat ccc acc gca tat 1315Pro Leu Ala Ala Tyr Leu Ala Leu Arg Gly Ala Asn Pro Thr Ala Tyr390 395 400 405ggt gcg tat ctt cag ctg ggg gat acc tct att ttg agt tcc tcg ccg 1363Gly Ala Tyr Leu Gln Leu Gly Asp Thr Ser Ile Leu Ser Ser Ser Pro

410 415 420gag cgg ttc atc acc att gat tcg gca ggg tat gtg gaa tca aag ccc 1411Glu Arg Phe Ile Thr Ile Asp Ser Ala Gly Tyr Val Glu Ser Lys Pro

425 430 435att aaa ggc acc agg ccg cgt ggg cga aca gcg caa gaa gac caa gaa 1459Ile Lys Gly Thr Arg Pro Arg Gly Arg Thr Ala Gln Glu Asp Gln Glu

440 445 450atc att gct gag ctg cgc agt aat cct aaa gat cgt gca gaa aac ttg 1507Ile Ile Ala Glu Leu Arg Ser Asn Pro Lys Asp Arg Ala Glu Asn Leu

455 460 465atg atc gtg gat ttg gtc cgc aac gac tta gcc cgc ggc gct ttg ccc 1555Met Ile Val Asp Leu Val Arg Asn Asp Leu Ala Arg Gly Ala Leu Pro470 475 480 485acc aca gtt aaa aca tcc aag ctt ttc gac gtc gaa acc tac gcc aca 1603Thr Thr Val Lys Thr Ser Lys Leu Phe Asp Val Glu Thr Tyr Ala Thr

490 495 500gtc cac caa ctt gtc agc acc gtc tct gca gag ttg ggg cca cgc agt 1651Val His Gln Leu Val Ser Thr Val Ser Ala Glu Leu Gly Pro Arg Ser

505 510 515ccg att gag tgc gtg cgc gca gca ttc ccc ggt ggt tcg atg act ggt 1699Pro Ile Glu Cys Val Arg Ala Ala Phe Pro Gly Gly SerMet Thr Gly

520 525 530gcc cca aag ctg cgc acc atg gag atc atc gat gag ctg gag gca gct 1747Ala Pro Lys Leu Arg Thr Met Glu Ile Ile Asp Glu Leu Glu Ala Ala

535 540 545cct cgc ggt att tac tca ggt ggc ttg gga tat ttt tcc ctc gac ggc 1795Pro Arg Gly Ile Tyr Ser Gly Gly Leu Gly Tyr Phe Ser Leu Asp Gly550 555 560 565gca gtt gat ctc tcc atg gtg atc aga act ctc gtc atc cag aac aat 1843Ala Val Asp Leu Ser Met Val Ile Arg Thr Leu Val Ile Gln Asn Asn

570 575 580cac gtg gag tac gga gtg ggc ggt gca ctt ctt gct ctg tct gat ccg 1891His Val Glu Tyr Gly Val Gly Gly Ala Leu Leu Ala Leu Ser Asp Pro

585 590 595gag gct gag tgg gag gaa atc cgc gtt aaa tca cgg cct ctg ctg aat 1939Glu Ala Glu Trp Glu Glu Ile Arg Val Lys Ser Arg Pro Leu Leu Asn

600 605 610ttg ttt ggg gtt gaa ttc cca tgacgtacct cgtgtgggac ggt 1983Leu Phe Gly Val Glu Phe Pro

615620<210>460<211>620<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>460Met Arg Val Leu Ile Ile Asp Asn Tyr Asp Ser Phe Thr Phe Asn Leu 151015 Ala Thr Tyr Val Glu Glu Val Thr Gly Gln Ala Pro Val Val Val Pro

20 25 30Asn Asp Gln Glu Ile Asp Glu Met Leu Phe Asp Ala Val Ile Leu Ser

35 40 45Pro Gly Pro Gly His Ala Gly Val Ala Ala Asp Phe Gly Ile Cys Ala

50 55 60Gly Val Ile Glu Arg Ala Arg Val Pro Ile Leu Gly Val Cys Leu Gly 6570 75 80His Gln Gly Ile Ala Leu Ala Tyr Gly Gly Asp Val Asp Leu Ala Pro

85 90 95Arg Pro Val His Gly Glu Val Ser Gln Ile Thr His Asp Gly Ser Gly

100 105 110Leu Phe Ala Gly Ile Pro Glu Thr Phe Glu Ala Val Arg Tyr His Ser

115 120 125Met Val Ala Thr Arg Leu Pro Glu Ser Leu Lys Ala Thr Ala Thr Ser

130 135 140Asp Asp Gly Leu Ile Met Ala Leu Ala His Glu Val Leu Pro Gln Trp145 150 155 160Gly Val Gln Phe His Pro Glu Ser Ile Gly Gly Gln Phe Gly His Gln

165 170 175Ile Ile Lys Asn Phe Leu Asn Leu Ala Arg Thr Tyr Arg Trp Gln Leu

180 185 190Thr Glu Lys Thr Ile Pro Leu Ser Val Asp Ser Ala Ala Val Phe Glu

195 200 205Thr Phe Phe Ala His Ser Ser His Ala Phe Trp Leu Asp Asp Ala Gln

210 215 220Gly Thr Ser Tyr Leu Gly Asp Ala Ser Gly Pro Leu Ala Arg Thr Lys225 230 235 240Thr His Asn Val Gly Glu Gly Asp Phe Phe Thr Trp Leu Lys Glu Asp

245 250 255Leu Ala Ala Asn Ser Val Ala Pro Gly Gln Gly Phe Arg Leu Gly Trp

260 265 270Val Gly Tyr Val Gly Tyr Glu Leu Lys Ala Glu Ala Gly Ala Arg Ala

275 280 285Ala His Thr Ser Ser Leu Pro Asp Ala His Leu Ile Phe Ala Asp Arg

290 295 300Ala Ile Ala Val Glu Ser Asp Gln Val Arg Leu Leu Ala Leu Gly Glu305 310 315 320Gln Asp Glu Trp Phe Glu Glu Thr Ile Lys Lys Leu His Asn Leu Val

325 330 335Ala Pro Arg Ile Pro Ala Ser Gly His Leu Ala Leu Gln Val Arg Asp

340 345 350Ser Lys Asp Glu Tyr Leu Asp Lys Ile Arg Arg Ala Gln Glu Leu Ile

355 360 365Thr Arg Gly Glu Ser Tyr Glu Ile Cys Leu Thr Thr Lys Leu Gln Gly

370 375 380Thr Thr Asp Val Ala Pro Leu Ala Ala Tyr Leu Ala Leu Arg Gly Ala385 390 395 400Asn Pro Thr Ala Tyr Gly Ala Tyr Leu Gln Leu Gly Asp Thr Ser Ile

405 410 415Leu Ser Ser Ser Pro Glu Arg Phe Ile Thr Ile Asp Ser Ala Gly Tyr

420 425 430Val Glu Ser Lys Pro Ile Lys Gly Thr Arg Pro Arg Gly Arg Thr Ala

435 440 445Gln Glu Asp Gln Glu Ile Ile Ala Glu Leu Arg Ser Asn Pro Lys Asp

450 455 460Arg Ala Glu Asn Leu Met Ile Val Asp Leu Val Arg Asn Asp Leu Ala465 470 475 480Arg Gly Ala Leu Pro Thr Thr Val Lys Thr Ser Lys Leu Phe Asp Val

485 490 495Glu Thr Tyr Ala Thr Val His Gln Leu Val Ser Thr Val Ser Ala Glu

500 505 510Leu Gly Pro Arg Ser Pro Ile Glu Cys Val Arg Ala Ala Phe Pro Gly

515 520 525Gly Ser Met Thr Gly Ala Pro Lys Leu Arg Thr Met Glu Ile Ile Asp

530 535 540Glu Leu Glu Ala Ala Pro Arg Gly Ile Tyr Ser Gly Gly Leu Gly Tyr545 550 555 560Phe Ser Leu Asp Gly Ala Val Asp Leu Ser Met Val Ile Arg Thr Leu

565 570 575Val Ile Gln Asn Asn His Val Glu Tyr Gly Val Gly Gly Ala Leu Leu

580 585 590Ala Leu Ser Asp Pro Glu Ala Glu Trp Glu Glu Ile Arg Val Lys Ser

595 600 605Arg Pro Leu Leu Asn Leu Phe Gly Val Glu Phe Pro

610615620<210>461<211>747<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (724)<223>RXA00958<400>461attctaatcc tcaatctgaa gccgatgaga cgttgcacaa ggcgtatgcc gtgttgaatg 60ccattgcgct tgctgctggt tccactttgg aggtcatccg atg aca cac gtt gtt 115

Met Thr His Val Val

1 5ctc att gat aat cac gat tct ttt gtc tac aac ctg gtg gat gcg ttc 163Leu Ile Asp Asn His Asp Ser Phe Val Tyr Asn Leu Val Asp Ala Phe

10 15 20gcc gtg gcc ggt tat aag tgc acg gtg ttc cgc aat acg gtg cca gtg 211Ala Val Ala Gly Tyr Lys Cys Thr Val Phe Arg Asn Thr Val Pro Val

25 30 35gaa acc att ttg gca gcc aac ccg gac ctg atc tgc ctt tca cct gga 259Glu Thr Ile Leu Ala Ala Asn Pro Asp Leu Ile Cys Leu Ser Pro Gly

40 45 50cct ggt tac cct gcc gat gcg ggc aac atg atg gcg ctg atc gag cgc 307Pro Gly Tyr Pro Ala Asp Ala Gly Asn Met Met Ala Leu Ile Glu Arg

55 60 65aca ctc ggc cag att cct tta ctg ggt att tgc ctc ggc tac cag gca 355Thr Leu Gly Gln Ile Pro Leu Leu Gly Ile Cys Leu Gly Tyr Gln Ala 70 75 80 85ctc atc gaa tac cac ggc ggc aag gtt gag cct tgt ggc cct gtg cac 403Leu Ile Glu Tyr His Gly Gly Lys Val Glu Pro Cys Gly Pro Val His

90 95 100ggc acc acc gac aac atg atc ctt act gat gca ggt gtg cag agc cct 451Gly Thr Thr Asp Asn Met Ile Leu Thr Asp Ala Gly Val Gln Ser Pro

105 110 115gtt ttt gca ggt ctt gcc act gat gtt gag cct gat cat cca gaa atc 499Val Phe Ala Gly Leu Ala Thr Asp Val Glu Pro Asp His Pro Glu Ile

120 125 130cca ggc cgc aag gtt cca att ggc cgt tat cac tca ctg ggc tgc gtg 547Pro Gly Arg Lys Val Pro Ile Gly Arg Tyr His Ser Leu Gly Cys Val

135 140 145gtt gcc cca gac ggt att gaa tca cta ggt acc tgt tcc tcg gag att 595Val Ala Pro Asp Gly Ile Glu Ser Leu Gly Thr Cys Ser Ser Glu Ile150 155 160 165ggt gat gtc atc atg gcg gca cgc acc acc gat gga aag gcc att ggc 643Gly Asp Val Ile Met Ala Ala Arg Thr Thr Asp Gly Lys Ala Ile Gly

170 175 180ctg cag ttt cac cct gag tca gtg cta agc cca acg ggt cct gtc att 691Leu Gln Phe His Pro Glu Ser Val Leu Ser Pro Thr Gly Pro Val Ile

185 190 195ttg tcc cgc tgt gtc gaa cag ctt ctc gcg aac taataaaaaa aggatttgat 744Leu Ser Arg Cys Val Glu Gln Leu Leu Ala Asn

200205 tca 747<210>462<211>208<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>462Met Thr His Val Val Leu Ile Asp Asn His Asp Ser Phe Val Tyr Asn 151015 Leu Val Asp Ala Phe Ala Val Ala Gly Tyr Lys Cys Thr Val Phe Arg

20 25 30Asn Thr Val Pro Val Glu Thr Ile Leu Ala Ala Asn Pro Asp Leu Ile

35 40 45Cys Leu Ser Pro Gly Pro Gly Tyr Pro Ala Asp Ala Gly Asn Met Met

50 55 60Ala Leu Ile Glu Arg Thr Leu Gly Gln Ile Pro Leu Leu Gly Ile Cys 65 70 75 80Leu Gly Tyr Gln Ala Leu Ile Glu Tyr His Gly Gly Lys Val Glu Pro

85 90 95Cys Gly Pro Val His Gly Thr Thr Asp Asn Met Ile Leu Thr Asp Ala

100 105 110Gly Val Gln Ser Pro Val Phe Ala Gly Leu Ala Thr Asp Val Glu Pro

115 120 125Asp His Pro Glu Ile Pro Gly Arg Lys Val Pro Ile Gly Arg Tyr His

130 135 140Ser Leu Gly Cys Val Val Ala Pro Asp Gly Ile Glu Ser Leu Gly Thr145 150 155 160Cys Ser Ser Glu Ile Gly Asp Val Ile Met Ala Ala Arg Thr Thr Asp

165 170 175Gly Lys Ala Ile Gly Leu Gln Phe His Pro Glu Ser Val Leu Ser Pro

180 185 190Thr Gly Pro Val Ile Leu Ser Arg Cys Val Glu Gln Leu Leu Ala Asn

195200205<210>463<211>469<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (469)<223>RXN03007<400>463cagtttcacc ctgagtcagt gctaagccca acgggtcctg tcattttgtc ccgctgtgtc 60gaacagcttc tcgcgaacta ataaaaaaag gatttgattc atg act tct cca gca 115

Met Thr Ser Pro Ala

1 5aca ctg aaa gtt ctc aac gcc tac ttg gat aac ccc act cca acc ctg 163Thr Leu Lys Val Leu Asn Ala Tyr Leu Asp Asn Pro Thr Pro Thr Leu

10 15 20gag gag gca att gag gtg ttc acc ccg ctg acc gtg ggt gaa tac gat 211Glu Glu Ala Ile Glu Val Phe Thr Pro Leu Thr Val Gly Glu Tyr Asp

25 30 35gac gtg cac atc gca gcg ctg ctt gcc acc atc cgt act cgc ggt gag 259Asp Val His Ile Ala Ala Leu Leu Ala Thr Ile Arg Thr Arg Gly Glu

40 45 50cag ttc gct gat att gcc ggc gct gcc aag gcg ttc ctc gcg gcg gct 307Gln Phe Ala Asp Ile Ala Gly Ala Ala Lys Ala Phe Leu Ala Ala Ala

55 60 65cgt ccg ttc ccg att act ggc gca ggt ttg cta gat tcc gct ggt act 355Arg Pro Phe Pro Ile Thr Gly Ala Gly Leu Leu Asp Ser Ala Gly Thr 70 75 80 85ggt ggc gac ggt gcc aac acc atc aac atc acc acc ggc gca tcc ctg 403Gly Gly Asp Gly Ala Asn Thr Ile Asn Ile Thr Thr Gly Ala Ser Leu

90 95 100atc gca gca tcc ggt gga gtg aag ctg gtt aag cac ggc aac cgt tcg 451Ile Ala Ala Ser Gly Gly Val Lys Leu Val Lys His Gly Asn Arg Ser

105110 115gtg agc tcc aag tcc ggc 469Val Ser Ser Lys Ser Gly

120<210>464<211>123<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>464Met Thr Ser Pro Ala Thr Leu Lys Val Leu Asn Ala Tyr Leu Asp Asn 151015 Pro Thr Pro Thr Leu Glu Glu Ala Ile Glu Val Phe Thr Pro Leu Thr

20 25 30Val Gly Glu Tyr Asp Asp Val His Ile Ala Ala Leu Leu Ala Thr Ile

35 40 45Arg Thr Arg Gly Glu Gln Phe Ala Asp Ile Ala Gly Ala Ala Lys Ala

50 55 60Phe Leu Ala Ala Ala Arg Pro Phe Pro Ile Thr Gly Ala Gly Leu Leu 65 70 75 80Asp Ser Ala Gly Thr Gly Gly Asp Gly Ala Asn Thr Ile Asn Ile Thr

85 90 95Thr Gly Ala Ser Leu Ile Ala Ala Ser Gly Gly Val Lys Leu Val Lys

100 105 110His Gly Asn Arg Ser Val Ser Ser Lys Ser Gly

115120<210>465<211>564<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (541)<223>RXN02918<400>465agattgtcgc ttttcccatt tctccgggtt ttctggaact ttttgggcgt atgctgggaa 60tgattctatt attgccaaat cagaaagcag gagagacccg atg agc gaa atc cta 115

Met Ser Glu Ile Leu

1 5gaa acc tat tgg gca ccc cac ttt gga aaa acc gaa gaa gcc aca gca 163Glu Thr Tyr Trp Ala Pro His Phe Gly Lys Thr Glu Glu Ala Thr Ala

10 15 20ctc gtt tca tac ctg gca caa gct tcc ggc gat ccc att gag gtt cac 211Leu Val Ser Tyr Leu Ala Gln Ala Ser Gly Asp Pro Ile Glu Val His

25 30 35acc ctg ttc ggg gat tta ggt tta gac gga ctc tct gga aac tac acc 259Thr Leu Phe Gly Asp Leu Gly Leu Asp Gly Leu Ser Gly Asn Tyr Thr

40 45 50gac act gag att gac ggc tac ggc gac gca ttc ctg ctg gtt gca gcg 307Asp Thr Glu Ile Asp Gly Tyr Gly Asp Ala Phe Leu Leu Val Ala Ala

55 60 65cta tcc gtg ttg atg gct gaa aac aaa gca aca ggt ggc gtg aat ctg 355Leu Ser Val Leu Met Ala Glu Asn Lys Ala Thr Gly Gly Val Asn Leu 70 75 80 85ggt gag ctt ggg gga gct gat aaa tcg atc cgg ctg cat gtt gaa tcc 403Gly Glu Leu Gly Gly Ala Asp Lys Ser Ile Arg Leu His Val Glu Ser

90 95 100aag gag aac acc caa atc aac acc gca ttg aag tat ttt gcg ctc tcc 451Lys Glu Asn Thr Gln Ile Asn Thr Ala Leu Lys Tyr Phe Ala Leu Ser

105 110 115cca gaa gac cac gca gca gca gat cgc ttc gat gag gat gac ctg tct 499Pro Glu Asp His Ala Ala Ala Asp Arg Phe Asp Glu Asp Asp Leu Ser

120 125 130gag ctt gcc aac ttg agt gaa gag ctg cgc gga cag ctg gac 541Glu Leu Ala Asn Leu Ser Glu Glu Leu Arg Gly Gln Leu Asp

135140145 taattgtctc ccatttaagg agt 564<210>466<211>147<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>466Met Ser Glu Ile Leu Glu Thr Tyr Trp Ala Pro His Phe Gly Lys Thr 151015 Glu Glu Ala Thr Ala Leu Val Ser Tyr Leu Ala Gln Ala Ser Gly Asp

20 25 30Pro Ile Glu Val His Thr Leu Phe Gly Asp Leu Gly Leu Asp Gly Leu

35 40 45Ser Gly Asn Tyr Thr Asp Thr Glu Ile Asp Gly Tyr Gly Asp Ala Phe

50 55 60Leu Leu Val Ala Ala Leu Ser Val Leu Met Ala Glu Asn Lys Ala Thr 65 70 75 80Gly Gly Val Asn Leu Gly Glu Leu Gly Gly Ala Asp Lys Ser Ile Arg

85 90 95Leu His Val Glu Ser Lys Glu Asn Thr Gln Ile Asn Thr Ala Leu Lys

100 105 110Tyr Phe Ala Leu Ser Pro Glu Asp His Ala Ala Ala Asp Arg Phe Asp

115 120 125Glu Asp Asp Leu Ser Glu Leu Ala Asn Leu Ser Glu Glu Leu Arg Gly

130135140 Gln Leu Asp145<210>467<211>735<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (712)<223>RXN01116<400>467tgccaggaat ttacgtcaac cgcgtcgtcc acgttggacc gcaggaaacc ggaatcgaaa 60acaggacggt gtctaactaa tgacttggga tcataaccaa atg gca gcc cgc gtt 115

Met Ala Ala Arg Val

1 5gcc cag gaa ctt gaa gac ggc cag tac gtc aac ctc ggc atc ggc atg 163Ala Gln Glu Leu Glu Asp Gly Gln Tyr Val Asn Leu Gly Ile Gly Met

10 15 20cct aca ctt atc ccc ggc tac ctg cct gag gga cta gag gtt atc ctt 211Pro Thr Leu Ile Pro Gly Tyr Leu Pro Glu Gly Leu Glu Val Ile Leu

25 3035cac tcc gaa aac ggt gtg ctg ggc gtt gga cct tac cca act gaa gag 259His Ser Glu Asn Gly Val Leu Gly Val Gly Pro Tyr Pro Thr Glu Glu

40 45 50gaa ctt gat cct gag ctg atc aac gcc ggc aag gaa acc atc acg gtt 307Glu Leu Asp Pro Glu Leu Ile Asn Ala Gly Lys Glu Thr Ile Thr Val

55 60 65gca cct ggc gca tcc tac ttc tcc tct tct gat tct ttc gcc atg atc 355Ala Pro Gly Ala Ser Tyr Phe Ser Ser Ser Asp Ser Phe Ala Met Ile 70 75 80 85cgc tcc aag tct gtc gac gtt gca gtc ttg ggc gtt atg gaa gtc tcc 403Arg Ser Lys Ser Val Asp Val Ala Val Leu Gly Val Met Glu Val Ser

90 95 100cag tac ggc gac ctg gcc aac tgg atg att ccc ggc aag ctg gtc aag 451Gln Tyr Gly Asp Leu Ala Asn Trp Met Ile Pro Gly Lys Leu Val Lys

105 110 115ggt atg ggt ggc gca atg gat ctg gtg cac ggc gca tcc aag atc atc 499Gly Met Gly Gly Ala Met Asp Leu Val His Gly Ala Ser Lys Ile Ile

120 125 130gcc atg acc gat cac atc acc aag aag ggc gct ccg aag atc ctt aag 547Ala Met Thr Asp His Ile Thr Lys Lys Gly Ala Pro Lys Ile Leu Lys

135 140 145gag tgt cgc ctc cca ctg act ggc gcg aag tgc gtg gac atg att gtc 595Glu Cys Arg Leu Pro Leu Thr Gly Ala Lys Cys Val Asp Met Ile Val150 155 160 165acc acc cac gct gtg ttc tct gtg gac cct gaa gaa ggc ctc acg ctc 643Thr Thr His Ala Val Phe Ser Val Asp Pro Glu Glu Gly Leu Thr Leu

170 175 180atc gag tgc gcc gac ggt gtc acc gtt gag gaa ctc cgc gaa atc acc 691Ile Glu Cys Ala Asp Gly ValThr Val Glu Glu Leu Arg Glu Ile Thr

185 190 195gaa gcc gat ttc aaa gtt gct taagcaaacg ctgcgcaatt aag 735Glu Ala Asp Phe Lys Val Ala

200<210>468<211>204<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>468Met Ala Ala Arg Val Ala Gln Glu Leu Glu Asp Gly Gln Tyr Val Asn 151015 Leu Gly Ile Gly Met Pro Thr Leu Ile Pro Gly Tyr Leu Pro Glu Gly

20 25 30Leu Glu Val Ile Leu His Ser Glu Asn Gly Val Leu Gly Val Gly Pro

35 40 45Tyr Pro Thr Glu Glu Glu Leu Asp Pro Glu Leu Ile Asn Ala Gly Lys

50 55 60Glu Thr Ile Thr Val Ala Pro Gly Ala Ser Tyr Phe Ser Ser Ser Asp 65 70 75 80Ser Phe Ala Met Ile Arg Ser Lys Ser Val Asp Val Ala Val Leu Gly

85 90 95Val Met Glu Val Ser Gln Tyr Gly Asp Leu Ala Asn Trp Met Ile Pro

100 105 110Gly Lys Leu Val Lys Gly Met Gly Gly Ala Met Asp Leu Val His Gly

115 120 125Ala Ser Lys Ile Ile Ala Met Thr Asp His Ile Thr Lys Lys Gly Ala

130 135 140Pro Lys Ile Leu Lys Glu Cys Arg Leu Pro Leu Thr Gly Ala Lys Cys145 150 155 160Val Asp Met Ile Val Thr Thr His Ala Val Phe Ser Val Asp Pro Glu

165 170 175Glu Gly Leu Thr Leu Ile Glu Cys Ala Asp Gly Val Thr Val Glu Glu

180185 190Leu Arg Glu Ile Thr Glu Ala Asp Phe Lys Val Ala

195200<210>469<211>876<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (853)<223>RXN01115<400>469<469ctcaccgcat gcagcgtgaa aacactcagt acggactggc caccatgtgc atcggtggcg 60gccagggtct tgcagctgtc tttgaaaagg agaactaaaa atg gct att ttg cac 115

Met Ala Ile Leu His

1 5agc gtt tcc tac gga act tcc gac aac acc ttg gtg ttc att ggc tcg 163Ser Val Ser Tyr Gly Thr Ser Asp Asn Thr Leu Val Phe Ile Gly Ser

10 15 20ttg ggt tcc acc acc gac atg tgg ctg cca cag ctg gat gcc ttg cat 211Leu Gly Ser Thr Thr Asp Met Trp Leu Pro Gln Leu Asp Ala Leu His

25 30 35aag gat ttc cgc gtc atc gct gtt gat cac cgc gga cat ggt ctg tct 259Lys Asp Phe Arg Val Ile Ala Val Asp His Arg Gly His Gly Leu Ser

40 45 50gaa ctc atc gaa ggc acc ccc act gtg gcg gat ctg gcg cag gat gtg 307Glu Leu Ile Glu Gly Thr Pro Thr Val Ala Asp Leu Ala Gln Asp Val

55 60 65ctg gat acc ctc gat gac ctg ggt gtc gga aac ttc ggc gtc atc gga 355Leu Asp Thr Leu Asp Asp Leu Gly Val Gly Asn Phe Gly Val Ile Gly 70 75 80 85cta tct ctc ggc gga gcg gtt gca caa tac ttg gcg gcc acc tct gat 403Leu Ser Leu Gly Gly Ala Val Ala Gln Tyr Leu Ala Ala Thr Ser Asp

90 95 100cgt gtc acc aag gca gca ttc atg tgt acc gct gca aaa ttc ggc gag 451Arg Val Thr Lys Ala Ala Phe Met Cys Thr Ala Ala Lys Phe Gly Glu

105 110 115ccc cag ggc tgg cta gat cgc gcc gca gcg tgc cgc gaa aac ggc act 499Pro Gln Gly Trp Leu Asp Arg Ala Ala Ala Cys Arg Glu Asn Gly Thr

120 125 130ggt tct ctg tcc gaa gct gtg atc cag cgc tgg ttc tcc ccc act tgg 547Gly Ser Leu Ser Glu Ala Val Ile Gln Arg Trp Phe Ser Pro Thr Trp

135 140 145ttg gag aac aac cca gcg tcc cgc gag cac ttc gaa gcc atg gtt gcc 595Leu Glu Asn Asn Pro Ala Ser Arg Glu His Phe Glu Ala Met Val Ala150 155 160 165ggc acc cca tct gag ggt tac gcg ctg tgc tgc gag gcg ttg gca acc 643Gly Thr Pro Ser Glu Gly Tyr Ala Leu Cys Cys Glu Ala Leu Ala Thr

170 175 180tgg gat ttc acc gat cgc ctg gga gaa atc acc gtg cca gtg ctc acc 691Trp Asp Phe Thr Asp Arg Leu Gly Glu Ile Thr Val Pro Val Leu Thr

185 190 195atc gca ggt gcc gat gac ccc tcc act cct cca gca acc gtg cag atc 739Ile Ala Gly Ala Asp Asp Pro Ser Thr Pro Pro Ala Thr Val Gln Ile

200 205 210att gcc gat ggc gtt ggc ggc gag tcc cgc gca gag gtc cta agc cca 787Ile Ala Asp Gly Val Gly Gly Glu Ser Arg Ala Glu Val Leu Ser Pro

215 220 225gcc gcg cac gta cca acc gtg gaa cgt cca aac gag gta aat gaa ctg 835Ala Ala His Val Pro Thr Val Glu Arg Pro Asn Glu Val Asn Glu Leu230 235 240 245cta gca cag cat ttc gct taatgttgta ggcatgttca caa 876Leu Ala Gln His Phe Ala

250<210>470<211>251<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>470Met Ala Ile Leu His Ser Val Ser Tyr Gly Thr Ser Asp Asn Thr Leu 151015 Val Phe Ile Gly Ser Leu Gly Ser Thr Thr Asp Met Trp Leu Pro Gln

20 25 30Leu Asp Ala Leu His Lys Asp Phe Arg Val Ile Ala Val Asp His Arg

35 40 45Gly His Gly Leu Ser Glu Leu Ile Glu Gly Thr Pro Thr Val Ala Asp

50 55 60Leu Ala Gln Asp Val Leu Asp Thr Leu Asp Asp Leu Gly Val Gly Asn 65 70 75 80Phe Gly Val Ile Gly Leu Ser Leu Gly Gly Ala Val Ala Gln Tyr Leu

85 90 95Ala Ala Thr Ser Asp Arg Val Thr Lys Ala Ala Phe Met Cys Thr Ala

100 105 110Ala Lys Phe Gly Glu Pro Gln Gly Trp Leu Asp Arg Ala Ala Ala Cys

115 120 125Arg Glu Asn Gly Thr Gly Ser Leu Ser Glu Ala Val Ile Gln Arg Trp

130 135 140Phe Ser Pro Thr Trp Leu Glu Asn Asn Pro Ala Ser Arg Glu His Phe145 150 155 160Glu Ala Met Val Ala Gly Thr Pro Ser Glu Gly Tyr Ala Leu Cys Cys

165 170 175Glu Ala Leu Ala Thr Trp Asp Phe Thr Asp Arg Leu Gly Glu Ile Thr

180 185 190Val Pro Val Leu Thr Ile Ala Gly Ala Asp Asp Pro Ser Thr Pro Pro

195 200 205Ala Thr Val Gln Ile Ile Ala Asp Gly Val Gly Gly Glu Ser Arg Ala

210 215220Glu Val Leu Ser Pro Ala Ala His Val Pro Thr Val Glu Arg Pro Asn225 230 235 240Glu Val Asn Glu Leu Leu Ala Gln His Phe Ala

245250<210>471<211>1284<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1261)<223>RXS00116<400>471cgcggcacgc acgctggggg caagcgtcga caagcacaaa ctttttgctt aattgaatcc 60tttgcgcacc aatcaatggg ggatcaaata tagtagctgc atg agt aat gac ttc 115

Met Ser Asn Asp Phe

1 5gtc gtt tct agg ctt aga ccc ttt ggt gaa acg att ttt gca acc atg 163Val Val Ser Arg Leu Arg Pro Phe Gly Glu Thr Ile Phe Ala Thr Met

10 15 20acc cag cga gct gtt gag gcg ggt gca atc aat ctt ggt cag ggc ttt 211Thr Gln Arg Ala Val Glu Ala Gly Ala Ile Asn Leu Gly Gln Gly Phe

25 30 35cct gat gag gat ggt cct cgt cgg atg tta gag atc gcg tcg gag cag 259Pro Asp Glu Asp Gly Pro Arg Arg Met Leu Glu Ile Ala Ser Glu Gln

40 45 50att ctc ggg gga aat aat cag tat tcg gcg ggg cgt ggg gat gct tcg 307Ile Leu Gly Gly Asn Asn Gln Tyr Ser Ala Gly Arg Gly Asp Ala Ser

55 60 65ttg agg gca gct gtg gct cgt gat cat ttg gag agg ttt gat ctg gag 355Leu Arg Ala Ala Val Ala Arg Asp His Leu Glu Arg Phe Asp Leu Glu 70 75 80 85tac aac cct gat tcg gag gtg ttg atc acg gtg ggg gcc act gag gcg 403Tyr Asn Pro Asp Ser Glu Val Leu Ile Thr Val Gly Ala Thr Glu Ala

90 95 100att acg gcg act gtg ttg ggt ttg gtg gag cct ggg gat gaa gtg atc 451Ile Thr Ala Thr Val Leu Gly Leu Val Glu Pro Gly Asp Glu Val Ile

105 110 115gtt ttg gaa ccg tat tac gat gcg tat gcg gcg gct att gcg ttg gcg 499Val Leu Glu Pro Tyr Tyr Asp Ala Tyr Ala Ala Ala Ile Ala Leu Ala

120 125 130ggg gcg acg cgg gtg gcg gtt cct ttg cag gag gtg gag aac tcg tgg 547Gly Ala Thr Arg Val Ala Val Pro Leu Gln Glu Val Glu Asn Ser Trp

135 140 145gat gtg gat gtc gat aag ttg cat gcg gcg gtg act aag aag acg cgg 595Asp Val Asp Val Asp Lys Leu His Ala Ala Val Thr Lys Lys Thr Arg150 155 160 165atg att atc gtt aat tcg ccg cat aat ccg acg ggt tcg gtg ttt tct 643Met Ile Ile Val Asn Ser Pro His Asn Pro Thr Gly Ser Val Phe Ser

170 175 180aag aag gcg ttg aag cag ttg gcg ggt gtt gct cgt gcg tat gac ttg 691Lys Lys Ala Leu Lys Gln Leu Ala Gly Val Ala Arg Ala Tyr Asp Leu

185 190 195ttg gtg ttg tca gat gag gtg tat gag cat ctt gtt ttt gat gat cag 739Leu Val Leu Ser Asp Glu Val Tyr Glu His Leu Val Phe Asp Asp Gln

200 205 210aag cat gtg agt gtc gcg aag ctg ccc ggt atg tgg gat cgc acg gtg 787Lys His Val Ser Val Ala Lys Leu Pro Gly Met Trp Asp Arg Thr Val

215 220 225acg gtg tcg tcg gcg gcg aaa acg ttc aat gtg act ggt tgg aag acg 835Thr Val Ser Ser Ala Ala Lys Thr Phe Asn Val Thr Gly Trp Lys Thr230 235 240 245ggg tgg gcg ttg gca ccg gag ccg ttg ttg gag gcg gtg ttg aag gcg 883Gly Trp Ala Leu Ala Pro Glu Pro Leu Leu Glu Ala Val Leu Lys Ala

250 255 260aag cag ttt atg tct tat gtg ggg gct aca cct ttt cag ccg gct gtg 931Lys Gln Phe Met Ser Tyr Val Gly Ala Thr Pro Phe Gln Pro Ala Val

265 270 275gcg cat gcg att gaa cat gag cag aag tgg gtg tca aag atg tct aag 979Ala His Ala Ile Glu His Glu Gln Lys Trp Val Ser Lys Met Ser Lys

280 285 290ggg ctt gag ctc aag cgg gat att ttg cgt act gcg tta gat aag gcg 1027Gly Leu Glu Leu Lys Arg Asp Ile Leu Arg Thr Ala Leu Asp Lys Ala

295 300 305ggg ctg aag act cat gac agt atg ggc acg tat ttc atc gtt gcg gat 1075Gly Leu Lys Thr His Asp Ser Met Gly Thr Tyr Phe Ile Val Ala Asp310 315 320 325att ggg gat cgt gat ggt gcg gag ttc tgt ttt gag ttg att gag aag 1123Ile Gly Asp Arg Asp Gly Ala Glu Phe Cys Phe Glu Leu Ile Glu Lys

330 335 340gtt ggg gtg gcg gcg att ccg gtg cag gcg ttt gtg gat cat ccg aag 1171Val Gly Val Ala Ala Ile Pro Val Gln Ala Phe Val Asp His Pro Lys

345 350 355aag tgg tcg tcg aag gtt cgt ttt gcg ttt tgc aaa aaa gaa gag acg 1219Lys Trp Ser Ser Lys Val Arg Phe Ala Phe Cys Lys Lys Glu Glu Thr

360 365 370ctc cgc gaa gct gcg gag cgt ctc aag ggg att aag aaa cta 1261Leu Arg Glu Ala Ala Glu Arg Leu Lys Gly Ile Lys Lys Leu

375380385 tagtttgaac aggttgttgg ggg 1284<210>472<211>387<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>472Met Ser Asn Asp Phe Val ValSer Arg Leu Arg Pro Phe Gly Glu Thr 151015 Ile Phe Ala Thr Met Thr Gln Arg Ala Val Glu Ala Gly Ala Ile Asn

20 25 30Leu Gly Gln Gly Phe Pro Asp Glu Asp Gly Pro Arg Arg Met Leu Glu

35 40 45Ile Ala Ser Glu Gln Ile Leu Gly Gly Asn Asn Gln Tyr Ser Ala Gly

50 55 60Arg Gly Asp Ala Ser Leu Arg Ala Ala Val Ala Arg Asp His Leu Glu 65 70 75 80Arg Phe Asp Leu Glu Tyr Asn Pro Asp Ser Glu Val Leu Ile Thr Val

85 90 95Gly Ala Thr Glu Ala Ile Thr Ala Thr Val Leu Gly Leu Val Glu Pro

100 105 110Gly Asp Glu Val Ile Val Leu Glu Pro Tyr Tyr Asp Ala Tyr Ala Ala

115 120 125Ala Ile Ala Leu Ala Gly Ala Thr Arg Val Ala Val Pro Leu Gln Glu

130 135 140Val Glu Asn Ser Trp Asp Val Asp Val Asp Lys Leu His Ala Ala Val145 150 155 160Thr Lys Lys Thr Arg Met Ile Ile Val Asn Ser Pro His Asn Pro Thr

165 170 175Gly Ser Val Phe Ser Lys Lys Ala Leu Lys Gln Leu Ala Gly Val Ala

180 185 190Arg Ala Tyr Asp Leu Leu Val Leu Ser Asp Glu Val Tyr Glu His Leu

195 200 205Val Phe Asp Asp Gln Lys His Val Ser Val Ala Lys Leu Pro Gly Met

210 215 220Trp Asp Arg Thr Val Thr Val Ser Ser Ala Ala Lys Thr Phe Asn Val225 230 235240Thr Gly Trp Lys Thr Gly Trp Ala Leu Ala Pro Glu Pro Leu Leu Glu

245 250 255Ala Val Leu Lys Ala Lys Gln Phe Met Ser Tyr Val Gly Ala Thr Pro

260 265 270Phe Gln Pro Ala Val Ala His Ala Ile Glu His Glu Gln Lys Trp Val

275 280 285Ser Lys Met Ser Lys Gly Leu Glu Leu Lys Arg Asp Ile Leu Arg Thr

290 295 300Ala Leu Asp Lys Ala Gly Leu Lys Thr His Asp Ser Met Gly Thr Tyr305 310 315 320Phe Ile Val Ala Asp Ile Gly Asp Arg Asp Gly Ala Glu Phe Cys Phe

325 330 335Glu Leu Ile Glu Lys Val Gly Val Ala Ala Ile Pro Val Gln Ala Phe

340 345 350Val Asp His Pro Lys Lys Trp Ser Ser Lys Val Arg Phe Ala Phe Cys

355 360 365Lys Lys Glu Glu Thr Leu Arg Glu Ala Ala Glu Arg Leu Lys Gly Ile

370375380 Lys Leu385<210>473<211>607<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) · (607)<223>FRXA00116<400>473tttgcgcacc aatcaatggg ggatcaaata tagtagctgc atgagtaatg acttcgtcgt 60ttctaggctt agaccctttg gtgaaacgat ttttgcaacc atg acc cag cga gct 115

Met Thr Gln Arg Ala

1 5gtt gag gcg ggt gca atc aat ctt ggt cag ggc ttt cct gat gag gat 163Val Glu Ala Gly Ala Ile Asn Leu Gly Gln Gly Phe Pro Asp Glu Asp

10 15 20ggt cct cgt cgg atg tta gag atc gcg tcg gag cag att ctc ggg gga 211Gly Pro Arg Arg Met Leu Glu Ile Ala Ser Glu Gln Ile Leu Gly Gly

25 30 35aat aat cag tat tcg gcg ggg cgt ggg gat gct tcg ttg agg gca gct 259Asn Asn Gln Tyr Ser Ala Gly Arg Gly Asp Ala Ser Leu Arg Ala Ala

40 45 50gtg gct cgt gat cat ttg gag agg ttt gat ctg gag tac aac cct gat 307Val Ala Arg Asp His Leu Glu Arg Phe Asp Leu Glu Tyr Asn Pro Asp

55 60 65tcg gag gtg ttg atc acg gtg ggg gcc act gag gcg att acg gcg act 355Ser Glu Val Leu Ile Thr Val Gly Ala Thr Glu Ala Ile Thr Ala Thr 70 75 80 85gtg ttg ggt ttg gtg gag cct ggg gat gaa gtg atc gtt ttg gaa ccg 403Val Leu Gly Leu Val Glu Pro Gly Asp Glu Val Ile Val Leu Glu Pro

90 95 100tat tac gat gcg tat gcg gcg gct att gcg ttg gcg ggg gcg acg cgg 451Tyr Tyr Asp Ala Tyr Ala Ala Ala Ile Ala Leu Ala Gly Ala Thr Arg

105 110 115gtg gcg gtt cct ttg cag gag gtg gag aac tcg tgg gat gtg gat gtc 499Val Ala Val Pro Leu Gln Glu Val Glu Asn Ser Trp Asp Val Asp Val

120 125 130gat aag ttg cat gcg gcg gtg act aag aag acg cgg atg att atc gtt 547Asp Lys Leu His Ala Ala Val Thr Lys Lys Thr Arg Met Ile Ile Val

135140145 aat tcg ccg cat aat ccg acg ggt tcg gtg ttt tct aag aag gcg ttg 595Asn Ser Pro His Asn Pro Thr Gly Ser Val Phe Ser Lys Lys Ala Leu 150155160165 aag cag ttg gcg 607Lys Gln Leu Ala<210>474<211>169<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>474Met Thr Gln Arg Ala Val Glu Ala Gly Ala Ile Asn Leu Gly Gln Gly 151015 Phe Pro Asp Glu Asp Gly Pro Arg Arg Met Leu Glu Ile Ala Ser Glu

20 25 30Gln Ile Leu Gly Gly Asn Asn Gln Tyr Ser Ala Gly Arg Gly Asp Ala

35 40 45Ser Leu Arg Ala Ala Val Ala Arg Asp His Leu Glu Arg Phe Asp Leu

50 55 60Glu Tyr Asn Pro Asp Ser Glu Val Leu Ile Thr Val Gly Ala Thr Glu 65 70 75 80Ala Ile Thr Ala Thr Val Leu Gly Leu Val Glu Pro Gly Asp Glu Val

85 90 95Ile Val Leu Glu Pro Tyr Tyr Asp Ala Tyr Ala Ala Ala Ile Ala Leu

100 105 110Ala Gly Ala Thr Arg Val Ala Val Pro Leu Gln Glu Val Glu Asn Ser

115 120 125Trp Asp Val Asp Val Asp Lys Leu His Ala Ala Val Thr Lys Lys Thr

130 135 140Arg Met Ile Ile Val Asn Ser Pro His Asn Pro Thr Gly Ser Val Phe145 150 155 160Ser Lys Lys Ala Leu Lys Gln Leu Ala

165<210>475<211>843<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (820)<223>RXS00391<400>475atcttgtaga tcccaccgca attctgggag atctcgagga cgcaatctct ggaagaaaac 60tttcctcccc atccctgtac aagataaaac ccgtgcacag ttg ctg cgc gat tct 115

Leu Leu Arg Asp Ser

1 5caa cga gtt ggc ctc gcc atc gat cct tcg atc gct ttg gtg atg gcc 163Gln Arg Val Gly Leu Ala Ile Asp Pro Ser Ile Ala Leu Val Met Ala

10 15 20act tct ggt tct aca ggt acc ccg aag ggc gct cag ctc act ccg ttg 211Thr Ser Gly Ser Thr Gly Thr Pro Lys Gly Ala Gln Leu Thr Pro Leu

25 30 35aat ttg gtg agt tcc gcc gat gct acg cat cag ttt tta ggt ggc gaa 259Asn Leu Val Ser Ser Ala Asp Ala Thr His Gln Phe Leu Gly Gly Glu

40 45 50ggc cag tgg ttg ctt gcc atg cca gca cac cac att gca ggc atg cag 307Gly Gln Trp Leu Leu Ala Met Pro Ala His His Ile Ala Gly Met Gln

55 60 65gtg ctt ctt cga agc ctc att gct gga gtt gag cca cta gct att gat 355Val Leu Leu Arg Ser Leu Ile Ala Gly Val Glu Pro Leu Ala Ile Asp 70 75 80 85ctc agc aca ggt ttt cac att gac gct ttc gca ggc gcc gcg gca gaa 403Leu Ser Thr Gly Phe His Ile Asp Ala Phe Ala Gly Ala Ala Ala Glu

90 95 100ctg aaa aat acc ggc gac cgc gtc tat aca tcc ttg act cca atg cag 451Leu Lys Asn Thr Gly Asp Arg Val Tyr Thr Ser Leu Thr Pro Met Gln

105 110 115tta ctt aaa gca atg gac tcc ttg caa ggc att gaa gcc ctg aaa ctt 499Leu Leu Lys Ala Met Asp Ser Leu Gln Gly Ile Glu Ala Leu Lys Leu

120 125 130ttt gat gtc att ctt gtt ggc ggt gct gca ttg tct aag cag gcc cga 547Phe Asp Val Ile Leu Val Gly Gly Ala Ala Leu Ser Lys Gln Ala Arg

135 140 145att tct gcg gag cag cta gac atc aac att gtc acc acc tac ggc tcc 595Ile Ser Ala Glu Gln Leu Asp Ile AsnIle Val Thr Thr Tyr Gly Ser150 155 160 165tca gag act tca ggt ggc tgc gtt tat gat ggc aag ccc att ccc ggc 643Ser Glu Thr Ser Gly Gly Cys Val Tyr Asp Gly Lys Pro Ile Pro Gly

170 175 180gcg aaa gtc cgt att tcg gat gag cgc att gag ttg ggt ggc ccg atg 691Ala Lys Val Arg Ile Ser Asp Glu Arg Ile Glu Leu Gly Gly Pro Met

185 190 195att gcg cag ggc tac aga aat gca cct gaa cat ccg gat ttc gcc aac 739Ile Ala Gln Gly Tyr Arg Asn Ala Pro Glu His Pro Asp Phe Ala Asn

200 205 210gag ggt tgg ttt acc acc tct gat tca ggt gaa ctc cac gac ggg att 787Glu Gly Trp Phe Thr Thr Ser Asp Ser Gly Glu Leu His Asp Gly Ile

215220225 ctc acc gtg act ggt cgc gtg gat acc cgt cat tgattccggt ggattgaagt 840Leu Thr Val Thr Gly Arg Val Asp Thr Arg His 230235240 tgc 843<210>476<211>240<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>476Leu Leu Arg Asp Ser Gln Arg Val Gly Leu Ala Ile Asp Pro Ser Ile 151015 Ala Leu Val Met Ala Thr Ser Gly Ser Thr Gly Thr Pro Lys Gly Ala

20 25 30Gln Leu Thr Pro Leu Asn Leu Val Ser Ser Ala Asp Ala Thr His Gln

35 40 45Phe Leu Gly Gly Glu Gly Gln Trp Leu Leu Ala Met Pro Ala His His

50 55 60Ile Ala Gly Met Gln Val Leu Leu Arg Ser Leu Ile Ala Gly Val Glu 65 70 75 80Pro Leu Ala Ile Asp Leu Ser Thr Gly Phe His Ile Asp Ala Phe Ala

85 90 95Gly Ala Ala Ala Glu Leu Lys Asn Thr Gly AspArg Val Tyr Thr Ser

100 105 110Leu Thr Pro Met Gln Leu Leu Lys Ala Met Asp Ser Leu Gln Gly Ile

115 120 125Glu Ala Leu Lys Leu Phe Asp Val Ile Leu Val Gly Gly Ala Ala Leu

130 135 140Ser Lys Gln Ala Arg Ile Ser Ala Glu Gln Leu Asp Ile Asn Ile Val145 150 155 160Thr Thr Tyr Gly Ser Ser Glu Thr Ser Gly Gly Cys Val Tyr Asp Gly

165 170 175Lys Pro Ile Pro Gly Ala Lys Val Arg Ile Ser Asp Glu Arg Ile Glu

180 185 190Leu Gly Gly Pro Met Ile Ala Gln Gly Tyr Arg Asn Ala Pro Glu His

195 200 205Pro Asp Phe Ala Asn Glu Gly Trp Phe Thr Thr Ser Asp Ser Gly Glu

210215220 Leu His Asp Gly Ile Leu Thr Val Thr Gly Arg Val Asp Thr Arg His 225230235240<210>477<211>1017<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (994)<223>RXS00393<400>477tctattcatt tcacaatagc gtttcacact cccccatagc ctgccgaacg tatttcaagc 60aattgcgcga tcgagtatgt gatggggaaa gatagaggtt atg tct cac acg gaa 115

Met Ser His Thr Glu

1 5ccc cag ccg aat tct gta act ttg tcc gat tgg att caa ggc gca cgc 163Pro Gln Pro Asn Ser Val Thr Leu Ser Asp Trp Ile Gln Gly Ala Arg

10 15 20ccg cgt acc tgg gca aat gcg ttc gcg cct gtc att gcc ggt tca ggt 211Pro Arg Thr Trp Ala Asn Ala Phe AlaPro Val Ile Ala Gly Ser Gly

25 30 35gtc gcc gct ttt cat gat ggt ttt gtg tgg tgg aag gcc ttg ctg gcg 259Val Ala Ala Phe His Asp Gly Phe Val Trp Trp Lys Ala Leu Leu Ala

40 45 50ctt gtc gtg gcg tgg gct ttg atc atc ggt gtg aat tac gcc aat gat 307Leu Val Val Ala Trp Ala Leu Ile Ile Gly Val Asn Tyr Ala Asn Asp

55 60 65tac tct gat ggc att cgt ggc acc gat gaa gac cgc acc ggt cct ctg 355Tyr Ser Asp Gly Ile Arg Gly Thr Asp Glu Asp Arg Thr Gly Pro Leu 70 75 80 85cga ctc act ggt tct ggg ttg gct gag ccg aag aaa gtg aaa gct gcg 403Arg Leu Thr Gly Ser Gly Leu Ala Glu Pro Lys Lys Val Lys Ala Ala

90 95 100gcg ttt att tct ttc ggt atc gca ggt gtc gcc ggc acc gcg ctg agc 451Ala Phe Ile Ser Phe Gly Ile Ala Gly Val Ala Gly Thr Ala Leu Ser

105 110 115ctg ttg agc gcg tgg tgg ctg atc ctc atc ggc atc ctg tgt gtg ctg 499Leu Leu Ser Ala Trp Trp Leu Ile Leu Ile Gly Ile Leu Cys Val Leu

120 125 130ggc gcg tgg ttc tac acc ggc ggt aaa aat cct tat ggt tac cgc ggg 547Gly Ala Trp Phe Tyr Thr Gly Gly Lys Asn Pro Tyr Gly Tyr Arg Gly

135 140 145ctc ggc gag att gct gtg ttc atc ttc ttc ggc ctc gtc gcg gtc atg 595Leu Gly Glu Ile Ala Val Phe Ile Phe Phe Gly Leu Val Ala Val Met150 155 160 165gga acg cag ttc acc caa acc ggt tcc gtc agc tgg gcc ggt ttg gcc 643Gly Thr Gln Phe Thr Gln Thr Gly Ser Val Ser Trp Ala Gly Leu Ala

170 175180gcc gca gtt ggc gtg ggg tcg atg tct gct ggc gtg aac ttg gcc aac 691Ala Ala Val Gly Val Gly Ser Met Ser Ala Gly Val Asn Leu Ala Asn

185 190 195aat att cgc gat att cca acc gat agc aag acc gga aaa att acc ctc 739Asn Ile Arg Asp Ile Pro Thr Asp Ser Lys Thr Gly Lys Ile Thr Leu

200 205 210gcg gtc cgc ctg ggc gat gcg ggt gct cgt aag ctg ttc ctc gcg ctg 787Ala Val Arg Leu Gly Asp Ala Gly Ala Arg Lys Leu Phe Leu Ala Leu

215 220 225att tcc acg ccg ttc atc atg tcc atc tgc ctg gcg ttt gtc gcc tgg 835Ile Ser Thr Pro Phe Ile Met Ser Ile Cys Leu Ala Phe Val Ala Trp230 235 240 245cca gcg ctg atc gcg atc atc gtt ttc ccg ctg gca ctg aaa gcc gca 883Pro Ala Leu Ile Ala Ile Ile Val Phe Pro Leu Ala Leu Lys Ala Ala

250 255 260ggg ccg atc cgc aac aac gcc acc ggc aag gat ctc atc ccc gtc atc 931Gly Pro Ile Arg Asn Asn Ala Thr Gly Lys Asp Leu Ile Pro Val Ile

265 270 275ggc tca aca ggg cgc gcc atg gcg ttg tgg gcc gtg ctc acg ggc ctg 979Gly Ser Thr Gly Arg Ala Met Ala Leu Trp Ala Val Leu Thr Gly Leu

280 285 290gca tta gcg ttt agc taaaacgctt ttcgacgctc ccc 1017Ala Leu Ala Phe Ser

295<210>478<211>298<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>478Met Ser His Thr Glu Pro Gln Pro Asn Ser Val Thr Leu Ser Asp Trp 151015 Ile Gln Gly Ala Arg Pro Arg Thr Trp Ala Asn Ala Phe Ala Pro Val

20 25 30Ile Ala Gly Ser Gly Val Ala Ala PheHis Asp Gly Phe Val Trp Trp

35 40 45Lys Ala Leu Leu Ala Leu Val Val Ala Trp Ala Leu Ile Ile Gly Val

50 55 60Asn Tyr Ala Asn Asp Tyr Ser Asp Gly Ile Arg Gly Thr Asp Glu Asp 65 70 75 80Arg Thr Gly Pro Leu Arg Leu Thr Gly Ser Gly Leu Ala Glu Pro Lys

85 90 95Lys Val Lys Ala Ala Ala Phe Ile Ser Phe Gly Ile Ala Gly Val Ala

100 105 110Gly Thr Ala Leu Ser Leu Leu Ser Ala Trp Trp Leu Ile Leu Ile Gly

115 120 125Ile Leu Cys Val Leu Gly Ala Trp Phe Tyr Thr Gly Gly Lys Asn Pro

130 135 140Tyr Gly Tyr Arg Gly Leu Gly Glu Ile Ala Val Phe Ile Phe Phe Gly145 150 155 160Leu Val Ala Val Met Gly Thr Gln Phe Thr Gln Thr Gly Ser Val Ser

165 170 175Trp Ala Gly Leu Ala Ala Ala Val Gly Val Gly Ser Met Ser Ala Gly

180 185 190Val Asn Leu Ala Asn Asn Ile Arg Asp Ile Pro Thr Asp Ser Lys Thr

195 200 205Gly Lys Ile Thr Leu Ala Val Arg Leu Gly Asp Ala Gly Ala Arg Lys

210 215 220Leu Phe Leu Ala Leu Ile Ser Thr Pro Phe Ile Met Ser Ile Cys Leu225 230 235 240Ala Phe Val Ala Trp Pro Ala Leu Ile Ala Ile Ile Val Phe Pro Leu

245 250 255Ala Leu Lys Ala Ala Gly Pro Ile Arg Asn Asn Ala Thr Gly Lys Asp

260 265 270Leu Ile Pro Val Ile Gly Ser Thr Gly Arg Ala Met Ala Leu Trp Ala

275 280 285Val Leu Thr Gly Leu Ala Leu Ala Phe Ser

290295<210>479<211>1005<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (982)<223>FRXA00393<400>479tctattcatt tcacaatagc gtttcacact cccccatagc ctgccgaacg tatttcaagc 60aattgcgcga tcgagtatgt gatggggaaa gatagaggtt atg tct cac acg gaa 115

Met Ser His Thr Glu

1 5ccc cag ccg aat tct gta act ttg tcc gat tgg att caa ggc gca cgc 163Pro Gln Pro Asn Ser Val Thr Leu Ser Asp Trp Ile Gln Gly Ala Arg

10 15 20ccg cgt acc tgg gca aat gcg ttc gcg cct gtc att gcc ggt tca ggt 211Pro Arg Thr Trp Ala Asn Ala Phe Ala Pro Val Ile Ala Gly Ser Gly

25 30 35gtc gcc gct ttt cat gat ggt ttt gtg tgg tgg aag gcc ttg ctg gcg 259Val Ala Ala Phe His Asp Gly Phe Val Trp Trp Lys Ala Leu Leu Ala

40 45 50ctt gtc gtg gcg tgg gct ttg atc atc ggt gtg aat tac gcc aat gat 307Leu Val Val Ala Trp Ala Leu Ile Ile Gly Val Asn Tyr Ala Asn Asp

55 60 65tac tct gat ggc att cgt ggc acc gat gaa gac cgc acc ggt cct ctg 355Tyr Ser Asp Gly Ile Arg Gly Thr Asp Glu Asp Arg Thr Gly Pro Leu 70 75 80 85cga ctc act ggt tct ggg ttg gct gag ccg aag aaa gtg aaa gct gcg 403Arg Leu Thr Gly Ser Gly Leu Ala Glu Pro Lys Lys Val Lys Ala Ala

90 95 100gcg ttt att tct ttc ggt atc gca ggt gtc gcc ggc acc gcg ctg agc 451Ala Phe Ile Ser Phe Gly Ile Ala Gly Val Ala Gly Thr Ala Leu Ser

105 110 115ctg ttg agc gcg tgg tgg ctg atc ctc atc ggc atc ctg tgt gtg ctg 499Leu Leu Ser Ala Trp Trp Leu Ile Leu Ile Gly Ile Leu Cys Val Leu

120 125 130ggc gcg tgg ttc tac acc ggc ggt aaa aat cct tat ggt tac cgc ggg 547Gly Ala Trp Phe Tyr Thr Gly Gly Lys Asn Pro Tyr Gly Tyr Arg Gly

135 140 145ctc ggc gag att gct gtg ttc atc ttc ttc ggc ctc gtc gcg gtc atg 595Leu Gly Glu Ile Ala Val Phe Ile Phe Phe Gly Leu Val Ala Val Met150 155 160 165gga acg cag ttc acc caa acc ggt tcc gtc agc tgg gcc ggt ttg gcc 643Gly Thr Gln Phe Thr Gln Thr Gly Ser Val Ser Trp Ala Gly Leu Ala

170 175 180gcc gca gtt ggc gtg ggg tcg atg tct gct ggc gtg aac ttg gcc aac 691Ala Ala Val Gly Val Gly Ser Met Ser Ala Gly Val Asn Leu Ala Asn

185 190 195aat att cgc gat att cca acc gat agc aag acc gga aaa att acc ctc 739Asn Ile Arg Asp Ile Pro Thr Asp Ser Lys Thr Gly Lys Ile Thr Leu

200 205 210gcg gtc cgc ctg ggc gat gcg ggt gct cgt aag ctg ttc ctc gcg ctg 787Ala Val Arg Leu Gly Asp Ala Gly Ala Arg Lys Leu Phe Leu Ala Leu

215 220 225att tcc acg ccg ttc atc atg tcc atc tgc ctg gcg ttt gtc gcc tgg 835Ile Ser Thr Pro Phe Ile Met Ser Ile Cys Leu Ala Phe Val Ala Trp230 235 240 245cca gcg ctg atc gcg atc atc gtt ttc ccg ctg gca ctg aaa gcc gca 883Pro Ala Leu Ile Ala Ile Ile Val Phe Pro Leu Ala Leu Lys Ala Ala

250 255 260ggg ccg atc cgc aac aac gcc acc ggc aag gat ctc atc ccg tca tcg 931Gly Pro Ile Arg Asn Asn Ala Thr Gly Lys Asp Leu Ile Pro Ser Ser

265 270 275gct caa cag ggc gcg cca tgg cgt tgt ggg ccg tgc tca cgg gcc tgg 979Ala Gln Gln Gly Ala Pro Trp Arg Cys Gly Pro Cys Ser Arg Ala Trp

280285290 cat tagcgtttag ctaaaacgct ttt 1005His<210>480<211>294<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>480Met Ser His Thr Glu Pro Gln Pro Asn Ser Val Thr Leu Ser Asp Trp 151015 Ile Gln Gly Ala Arg Pro Arg Thr Trp Ala Asn Ala Phe Ala Pro Val

20 25 30Ile Ala Gly Ser Gly Val Ala Ala Phe His Asp Gly Phe Val Trp Trp

35 40 45Lys Ala Leu Leu Ala Leu Val Val Ala Trp Ala Leu Ile Ile Gly Val

50 55 60Asn Tyr Ala Asn Asp Tyr Ser Asp Gly Ile Arg Gly Thr Asp Glu Asp 65 70 75 80Arg Thr Gly Pro Leu Arg Leu Thr Gly Ser Gly Leu Ala Glu Pro Lys

85 90 95Lys Val Lys Ala Ala Ala Phe Ile Ser Phe Gly Ile Ala Gly Val Ala

100 105 110Gly Thr Ala Leu Ser Leu Leu Ser Ala Trp Trp Leu Ile Leu Ile Gly

115 120 125Ile Leu Cys Val Leu Gly Ala Trp Phe Tyr Thr Gly Gly Lys Asn Pro

130135 140Tyr Gly Tyr Arg Gly Leu Gly Glu Ile Ala Val Phe Ile Phe Phe Gly145 150 155 160Leu Val Ala Val Met Gly Thr Gln Phe Thr Gln Thr Gly Ser Val Ser

165 170 175Trp Ala Gly Leu Ala Ala Ala Val Gly Val Gly Ser Met Ser Ala Gly

180 185 190Val Asn Leu Ala Asn Asn Ile Arg Asp Ile Pro Thr Asp Ser Lys Thr

195 200 205Gly Lys Ile Thr Leu Ala Val Arg Leu Gly Asp Ala Gly Ala Arg Lys

210 215 220Leu Phe Leu Ala Leu Ile Ser Thr Pro Phe Ile Met Ser Ile Cys Leu225 230 235 240Ala Phe Val Ala Trp Pro Ala Leu Ile Ala Ile Ile Val Phe Pro Leu

245 250 255Ala Leu Lys Ala Ala Gly Pro Ile Arg Asn Asn Ala Thr Gly Lys Asp

260 265 270Leu Ile Pro Ser Ser Ala Gln Gln Gly Ala Pro Trp Arg Cys Gly Pro

275 280 285Cys Ser Arg Ala Trp His

290<210>481<211>987<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (964)<223>RXS00446<400>481tgctacgaag ttatctagta atgaagttag tttttcccct ctcccggcag cagttgatgc 60ggtgacggag gctacttggg gggctaatcg gtacccggat atg ggt gcg gtt gag 115

Met Gly Ala Val Glu

1 5ctc cgt gag gct ctt gca gag cat tta gag gtt gag ttt gac cag gtc 163Leu Arg Glu Ala Leu AlaGlu His Leu Glu Val Glu Phe Asp Gln Val

10 15 20acg gta ggt tgc ggc tcg tct gcg ctg tgt caa cag ctg gtt cag gca 211Thr Val Gly Cys Gly Ser Ser Ala Leu Cys Gln Gln Leu Val Gln Ala

25 30 35acg tgc gct cag ggc gat gag gtc att ttt cca tgg cgc agc ttt gag 259Thr Cys Ala Gln Gly Asp Glu Val Ile Phe Pro Trp Arg Ser Phe Glu

40 45 50gct tat cca att ttc gcg cag gtc gcg ggc gcc act cct gtt gcc att 307Ala Tyr Pro Ile Phe Ala Gln Val Ala Gly Ala Thr Pro Val Ala Ile

55 60 65ccg ctg act gct gat cag aat cat gat ctt gat gcg atg gca gcc gcg 355Pro Leu Thr Ala Asp Gln Asn His Asp Leu Asp Ala Met Ala Ala Ala 70 75 80 85atc act gat aag acc cgc ctc att ttc atc tgc aac ccc aac aat cct 403Ile Thr Asp Lys Thr Arg Leu Ile Phe Ile Cys Asn Pro Asn Asn Pro

90 95 100tcg ggc acc acc atc acc cag gcg cag ttt gat aat ttc atg gaa aag 451Ser Gly Thr Thr Ile Thr Gln Ala Gln Phe Asp Asn Phe Met Glu Lys

105 110 115gtt cca aac gat gtc gtt gtt ggg ctg gat gag gct tat ttt gag ttc 499Val Pro Asn Asp Val Val Val Gly Leu Asp Glu Ala Tyr Phe Glu Phe

120 125 130aac cgc gcg gac gac acc cca gtt gcc act gag gaa atc cac cgc cac 547Asn Arg Ala Asp Asp Thr Pro Val Ala Thr Glu Glu Ile His Arg His

135 140 145gac aac gtg att ggt ttg cgc acg ttc tcc aag gcg tat ggc ctg gcg 595Asp Asn Val Ile Gly Leu Arg Thr Phe Ser Lys Ala Tyr Gly Leu Ala150 155 160165ggc ttg cgt gtt ggt tac gcc ttc gga aac gca gag atc atc gca gcg 643Gly Leu Arg Val Gly Tyr Ala Phe Gly Asn Ala Glu Ile Ile Ala Ala

170 175 180atg aat aag gtg gct att cct ttc gcg gtg aat tca gca gct cag gcg 691Met Asn Lys Val Ala Ile Pro Phe Ala Val Asn Ser Ala Ala Gln Ala

185 190 195gca gcg ctt gcg agt ttg aat tct gcc gat gag ttg atg gaa cgg gtg 739Ala Ala Leu Ala Ser Leu Asn Ser Ala Asp Glu Leu Met Glu Arg Val

200 205 210gag gaa acc gtc gaa aag cgt gat gct gtg gtg tca gcg ctt ggt gct 787Glu Glu Thr Val Glu Lys Arg Asp Ala Val Val Ser Ala Leu Gly Ala

215 220 225gcg ccg acg cag gcc aat ttc gtc tgg ctg ccg ggc gag ggc gcc gct 835Ala Pro Thr Gln Ala Asn Phe Val Trp Leu Pro Gly Glu Gly Ala Ala230 235 240 245gag ttg gcg gct aaa ttg gcc gag cac ggc atc gtg att cgc gcg ttc 883Glu Leu Ala Ala Lys Leu Ala Glu His Gly Ile Val Ile Arg Ala Phe

250 255 260ccc gag ggt gcg cgc att tcg gtg acc aac gcc gag gaa act gac aag 931Pro Glu Gly Ala Arg Ile Ser Val Thr Asn Ala Glu Glu Thr Asp Lys

265 270 275ctg ctg cgc gcg tgg gag gcc atc aat gct ggg tagtctttgg cgttttgcgg 984Leu Leu Arg Ala Trp Glu Ala Ile Asn Ala Gly

280285 tgc 987<210>482<211>288<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>482Met Gly Ala Val Glu Leu Arg Glu Ala Leu Ala Glu His Leu Glu Val 151015 Glu Phe Asp Gln Val Thr Val Gly Cys Gly Ser Ser Ala Leu Cys Gln

20 25 30Gln Leu Val Gln Ala Thr Cys Ala Gln Gly Asp Glu Val Ile Phe Pro

35 40 45Trp Arg Ser Phe Glu Ala Tyr Pro Ile Phe Ala Gln Val Ala Gly Ala

50 55 60Thr Pro Val Ala Ile Pro Leu Thr Ala Asp Gln Asn His Asp Leu Asp 65 70 75 80Ala Met Ala Ala Ala Ile Thr Asp Lys Thr Arg Leu Ile Phe Ile Cys

85 90 95Asn Pro Asn Asn Pro Ser Gly Thr Thr Ile Thr Gln Ala Gln Phe Asp

100 105 110Asn Phe Met Glu Lys Val Pro Asn Asp Val Val Val Gly Leu Asp Glu

115 120 125Ala Tyr Phe Glu Phe Asn Arg Ala Asp Asp Thr Pro Val Ala Thr Glu

130 135 140Glu Ile His Arg His Asp Asn Val Ile Gly Leu Arg Thr Phe Ser Lys145 150 155 160Ala Tyr Gly Leu Ala Gly Leu Arg Val Gly Tyr Ala Phe Gly Asn Ala

165 170 175Glu Ile Ile Ala Ala Met Asn Lys Val Ala Ile Pro Phe Ala Val Asn

180 185 190Ser Ala Ala Gln Ala Ala Ala Leu Ala Ser Leu Asn Ser Ala Asp Glu

195 200 205Leu Met Glu Arg Val Glu Glu Thr Val Glu Lys Arg Asp Ala Val Val

210 215 220Ser Ala Leu Gly Ala Ala Pro Thr Gln Ala Asn Phe Val Trp Leu Pro225 230 235 240Gly Glu Gly Ala Ala Glu Leu Ala Ala Lys Leu Ala Glu His Gly Ile

245 250255Val Ile Arg Ala Phe Pro Glu Gly Ala Arg Ile Ser Val Thr Asn Ala

260 265 270Glu Glu Thr Asp Lys Leu Leu Arg Ala Trp Glu Ala Ile Asn Ala Gly

275280285<210>483<211>545<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) } (522)<223>FRXA00446<400>483atg gaa aag gtt cca aac gat gtc gtt gtt ggg ctg gat gag gct tat 48Met Glu Lys Val Pro Asn Asp Val Val Val Gly Leu Asp Glu Ala Tyr 151015 ttt gag ttc aac cgc gcg gac gac acc cca gtt gcc act gag gaa atc 96Phe Glu Phe Asn Arg Ala Asp Asp Thr Pro Val Ala Thr Glu Glu Ile

20 25 30cac cgc cac gac aac gtg att ggt ttg cgc acg ttc tcc aag gcg tat 144His Arg His Asp Asn Val Ile Gly Leu Arg Thr Phe Ser Lys Ala Tyr

35 40 45ggc ctg gcg ggc ttg cgt gtt ggt tac gcc ttc gga aac gca gag atc 192Gly Leu Ala Gly Leu Arg Val Gly Tyr Ala Phe Gly Asn Ala Glu Ile

50 55 60atc gca gcg atg aat aag gtg gct att cct ttc gcg gtg aat tca gca 240Ile Ala Ala Met Asn Lys Val Ala Ile Pro Phe Ala Val Asn Ser Ala 65 70 75 80gct cag gcg gca gcg ctt gcg agt ttg aat tct gcc gat gag ttg atg 288Ala Gln Ala Ala Ala Leu Ala Ser Leu Asn Ser Ala Asp Glu Leu Met

85 90 95gaa cgg gtg gag gaa acc gtc gaa aag cgt gat gct gtg gtg tca gcg 336Glu Arg Val Glu Glu Thr Val Glu Lys Arg Asp Ala Val Val Ser Ala

100 105 110ctt ggt gct gcg ccg acg cag gcc aat ttc gtc tgg ctg ccg ggc gag 384Leu Gly Ala Ala Pro Thr Gln Ala Asn Phe Val Trp Leu Pro Gly Glu

115 120 125ggc gcc gct gag ttg gcg gct aaa ttg gcc gag cac ggc atc gtg att 432Gly Ala Ala Glu Leu Ala Ala Lys Leu Ala Glu His Gly Ile Val Ile

130 135 140cgc gcg ttc ccc gag ggt gcg cgc att tcg gtg acc aac gcc gag gaa 480Arg Ala Phe Pro Glu Gly Ala Arg Ile Ser Val Thr Asn Ala Glu Glu145 150 155 160act gac aag ctg ctg cgc gcg tgg gag gcc atc aat gct ggg 522Thr Asp Lys Leu Leu Arg Ala Trp Glu Ala Ile Asn Ala Gly

165170 tagtctttgg cgttttgcgg tgc 545<210>484<211>174<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>484Met Glu Lys Val Pro Asn Asp Val Val Val Gly Leu Asp Glu Ala Tyr 151015 Phe Glu Phe Asn Arg Ala Asp Asp Thr Pro Val Ala Thr Glu Glu Ile

20 25 30His Arg His Asp Asn Val Ile Gly Leu Arg Thr Phe Ser Lys Ala Tyr

35 40 45Gly Leu Ala Gly Leu Arg Val Gly Tyr Ala Phe Gly Asn Ala Glu Ile

50 55 60Ile Ala Ala Met Asn Lys Val Ala Ile Pro Phe Ala Val Asn Ser Ala 65 70 75 80Ala Gln Ala Ala Ala Leu Ala Ser Leu Asn Ser Ala Asp Glu Leu Met

85 90 95Glu Arg Val Glu Glu Thr Val Glu Lys Arg Asp Ala Val Val Ser Ala

100 105 110Leu Gly Ala Ala Pro Thr Gln Ala Asn Phe Val Trp Leu Pro Gly Glu

115 120 125Gly Ala Ala Glu Leu Ala Ala Lys Leu Ala Glu His Gly Ile Val Ile

130135 140Arg Ala Phe Pro Glu Gly Ala Arg Ile Ser Val Thr Asn Ala Glu Glu145 150 155 160Thr Asp Lys Leu Leu Arg Ala Trp Glu Ala Ile Asn Ala Gly

165170<210>485<211>1230<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1207)<223>RXS00618<400>485gctgcattag agggtcgtat ctcgatctaa aagcagtacg cagataggct tgtctcttat 60gaagccaagc actagaagca atgttcagcc gtttcgcgtc atg cag atg ttg gac 115

Met Gln Met Leu Asp

1 5cga gtc cac cgt cgc agg cgc gaa ggc aaa gac acc tta atg ttc tgc 163Arg Val His Arg Arg Arg Arg Glu Gly Lys Asp Thr Leu Met Phe Cys

10 15 20gct ggc cag ccg tca act ggt gcg cca gaa gca gtc atc gaa gaa gca 211Ala Gly Gln Pro Ser Thr Gly Ala Pro Glu Ala Val Ile Glu Glu Ala

25 30 35gag atc gct ctt cgc tcg ggt cct ttg gga tac acc gag gtg att ggt 259Glu Ile Ala Leu Arg Ser Gly Pro Leu Gly Tyr Thr Glu Val Ile Gly

40 45 50gat cgt gag ttc cgt gaa cgc atc gcc gat tgg cac tct gct act tat 307Asp Arg Glu Phe Arg Glu Arg Ile Ala Asp Trp His Ser Ala Thr Tyr

55 60 65gac gta gac acc aac cct gac aat gtt att gtc acc acc ggt tct tca 355Asp Val Asp Thr Asn Pro Asp Asn Val Ile Val Thr Thr Gly Ser Ser 70 75 80 85ggt gga ttc gtg gca tcg ttt atc gcc acc ttg gat cac ggg gat tat 403Gly Gly Phe Val Ala Ser Phe Ile Ala Thr Leu Asp His Gly Asp Tyr

90 95 100gtg gca atg cct acc ccg ggg tac ccg gca tat cgc aat att ctg gaa 451Val Ala Met Pro Thr Pro Gly Tyr Pro Ala Tyr Arg Asn Ile Leu Glu

105 110 115tct ttg ggg gcg aag gtt ctg aac ctg cgc tgt act gca gag act cgt 499Ser Leu Gly Ala Lys Val Leu Asn Leu Arg Cys Thr Ala Glu Thr Arg

120 125 130ttc cag cca acc gct caa atg ttg gag gaa ctg cca cac aag ccg aag 547Phe Gln Pro Thr Ala Gln Met Leu Glu Glu Leu Pro His Lys Pro Lys

135 140 145gct gtt att gtc acc agc cca gga aac cca acg ggc acc atc att gat 595Ala Val Ile Val Thr Ser Pro Gly Asn Pro Thr Gly Thr Ile Ile Asp150 155 160 165ccg gaa gag cta gag cgc atc gcc aag tgg tgc gat gac aat gat gct 643Pro Glu Glu Leu Glu Arg Ile Ala Lys Trp Cys Asp Asp Asn Asp Ala

170 175 180gtt ctt atc tct gat gag gac tac cac ggc atg agc ttt ggt cgt ccg 691Val Leu Ile Ser Asp Glu Asp Tyr His Gly Met Ser Phe Gly Arg Pro

185 190 195ctg gca act gcg cat cag ttt tcc aag aac gcc atc gtg gtg ggt acc 739Leu Ala Thr Ala His Gln Phe Ser Lys Asn Ala Ile Val Val Gly Thr

200 205 210ttg tcc aag tac ttc tcc atg acg ggt tgg cgc gtg ggt tgg atc atc 787Leu Ser Lys Tyr Phe Ser Met Thr Gly Trp Arg Val Gly Trp Ile Ile

215 220 225gtt cca gat gag ctg gtc aca ccg att gaa aac ctg cag gct tct ctt 835Val Pro Asp Glu Leu Val Thr Pro Ile Glu Asn Leu Gln Ala Ser Leu230 235 240 245tcc ttg tgt gct cct gcc atc ggg cag gct gcggga cgc gca gcc ttc 883Ser Leu Cys Ala Pro Ala Ile Gly Gln Ala Ala Gly Arg Ala Ala Phe

250 255 260act ttg gag gct ggg gcc gaa ctt gat gcc cac gtt gaa gcg tat cgc 931Thr Leu Glu Ala Gly Ala Glu Leu Asp Ala His Val Glu Ala Tyr Arg

265 270 275gag gcc cgg gag gtg ttc gtc gat aag ctc cct gaa atc ggg ctt ggc 979Glu Ala Arg Glu Val Phe Val Asp Lys Leu Pro Glu Ile Gly Leu Gly

280 285 290act ttc gcc gac ccg gat ggc ggc ctg tat ttg tgg gtc gat gtt tct 1027Thr Phe Ala Asp Pro Asp Gly Gly Leu Tyr Leu Trp Val Asp Val Ser

295 300 305gca tac acc gat gat tca gag gaa tgg gca ttg cgt ttg ctc gat gaa 1075Ala Tyr Thr Asp Asp Ser Glu Glu Trp Ala Leu Arg Leu Leu Asp Glu310 315 320 325gcg ggc gtg gcc gtc gcg ccg ggt gtt gat ttt gat cct gag gaa ggc 1123Ala Gly Val Ala Val Ala Pro Gly Val Asp Phe Asp Pro Glu Glu Gly

330 335 340cac aag tgg att cgt ttg agc ctg tgc gcg tca aag gaa gac acc att 1171His Lys Trp Ile Arg Leu Ser Leu Cys Ala Ser Lys Glu Asp Thr Ile

345 350 355gaa ggt gtg cgc aaa atc gga gaa ttc atc aaa aaa tagcagcgac 1217Glu Gly Val Arg Lys Ile Gly Glu Phe Ile Lys Lys

360365 taggttagtt tcg 1230<210>486<211>369<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>486Met Gln Met Leu Asp Arg Val His Arg Arg Arg Arg Glu Gly Lys Asp 151015 Thr Leu Met Phe Cys Ala Gly Gln Pro Ser Thr Gly Ala Pro Glu Ala

20 25 30Val Ile GluGlu Ala Glu Ile Ala Leu Arg Ser Gly Pro Leu Gly Tyr

35 40 45Thr Glu Val Ile Gly Asp Arg Glu Phe Arg Glu Arg Ile Ala Asp Trp

50 55 60His Ser Ala Thr Tyr Asp Val Asp Thr Asn Pro Asp Asn Val Ile Val65 70 75 80Thr Thr Gly Ser Ser Gly Gly Phe Val Ala Ser Phe Ile Ala Thr Leu

85 90 95Asp His Gly Asp Tyr Val Ala Met Pro Thr Pro Gly Tyr Pro Ala Tyr

100 105 1l0Arg Asn Ile Leu Glu Ser Leu Gly Ala Lys Val Leu Asn Leu Arg Cys

115 120 125Thr Ala Glu Thr Arg Phe Gln Pro Thr Ala Gln Met Leu Glu Glu Leu

130 135 140Pro His Lys Pro Lys Ala Val Ile Val Thr Ser Pro Gly Asn Pro Thr145 150 155 160Gly Thr Ile Ile Asp Pro Glu Glu Leu Glu Arg Ile Ala Lys Trp Cys

165 170 175Asp Asp Asn Asp Ala Val Leu Ile Ser Asp Glu Asp Tyr His Gly Met

180 185 190Ser Phe Gly Arg Pro Leu Ala Thr Ala His Gln Phe Ser Lys Asn Ala

195 200 205Ile Val Val Gly Thr Leu Ser Lys Tyr Phe Ser Met Thr Gly Trp Arg

210 215 220Val Gly Trp Ile Ile Val Pro Asp Glu Leu Val Thr Pro Ile Glu Asn225 230 235 240Leu Gln Ala Ser Leu Ser Leu Cys Ala Pro Ala Ile Gly Gln Ala Ala

245 250 255Gly ArgAla Ala Phe Thr Leu Glu Ala Gly Ala Glu Leu Asp Ala His

260 265 270Val Glu Ala Tyr Arg Glu Ala Arg Glu Val Phe Val Asp Lys Leu Pro

275 280 285Glu Ile Gly Leu Gly Thr Phe Ala Asp Pro Asp Gly Gly Leu Tyr Leu

290 295 300Trp Val Asp Val Ser Ala Tyr Thr Asp Asp Ser Glu Glu Trp Ala Leu305 310 315 320Arg Leu Leu Asp Glu Ala Gly Val Ala Val Ala Pro Gly Val Asp Phe

325 330 335Asp Pro Glu Glu Gly His Lys Trp Ile Arg Leu Ser Leu Cys Ala Ser

340 345 350Lys Glu Asp Thr Ile Glu Gly Val Arg Lys Ile Gly Glu Phe Ile Lys

355360365 Lys<210>487<211>657<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (634)<223>FRXA00618<400>487cccaacgggc accatcattg atccggaaga gctagagcgc atcgccaagt ggtgcgatga 60caatgatgct gttcttatct ctgatgagga ctaccacggc atg agc ttt ggt cgt 115

Met Ser Phe Gly Arg

1 5ccg ctg gca act gcg cat cag ttt tcc aag aac gcc atc gtg gtg ggt 163Pro Leu Ala Thr Ala His Gln Phe Ser Lys Asn Ala Ile Val Val Gly

l0 15 20acc ttg tcc aag tac ttc tcc atg acg ggt tgg cgc gtg ggt tgg atc 211Thr Leu Ser Lys Tyr Phe Ser Met Thr Gly Trp Arg Val Gly Trp Ile

25 30 35atc gtt cca gat gag ctg gtc aca ccg att gaa aac ctg cag gct tct 259Ile Val Pro Asp Glu Leu Val Thr Pro Ile Glu Asn Leu Gln Ala Ser

40 45 50ctt tcc ttg tgt gct cct gcc atc ggg cag gct gcg gga cgc gca gcc 307Leu Ser Leu Cys Ala Pro Ala Ile Gly Gln Ala Ala Gly Arg Ala Ala

55 60 65ttc act ttg gag gct ggg gcc gaa ctt gat gcc cac gtt gaa gcg tat 355Phe Thr Leu Glu Ala Gly Ala Glu Leu Asp Ala His Val Glu Ala Tyr 70 75 80 85cgc gag gcc cgg gag gtg ttc gtc gat aag ctc cct gaa atc ggg ctt 403Arg Glu Ala Arg Glu Val Phe Val Asp Lys Leu Pro Glu Ile Gly Leu

90 95 100ggc act ttc gcc gac ccg gat ggc ggc ctg tat ttg tgg gtc gat gtt 451Gly Thr Phe Ala Asp Pro Asp Gly Gly Leu Tyr Leu Trp Val Asp Val

105 110 115tct gca tac acc gat gat tca gag gaa tgg gca ttg cgt ttg ctc gat 499Ser Ala Tyr Thr Asp Asp Ser Glu Glu Trp Ala Leu Arg Leu Leu Asp

120 125 130gaa gcg ggc gtg gcc gtc gcg ccg ggt gtt gat ttt gat cct gag gaa 547Glu Ala Gly Val Ala Val Ala Pro Gly Val Asp Phe Asp Pro Glu Glu

135 140 145ggc cac aag tgg att cgt ttg agc ctg tgc gcg tca aag gaa gac acc 595Gly His Lys Trp Ile Arg Leu Ser Leu Cys Ala Ser Lys Glu Asp Thr150 155 160 165att gaa ggt gtg cgc aaa atc gga gaa ttc atc aaa aaa tagcagcgac 644Ile Glu Gly Val Arg Lys Ile Gly Glu Phe Ile Lys Lys

170175 taggttagtt tcg 657<210>488<211>178<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>488Met Ser Phe Gly Arg Pro Leu Ala Thr Ala His Gln Phe SerLys Asn 151015 Ala Ile Val Val Gly Thr Leu Ser Lys Tyr Phe Ser Met Thr Gly Trp

20 25 30Arg Val Gly Trp Ile Ile Val Pro Asp Glu Leu Val Thr Pro Ile Glu

35 40 45Asn Leu Gln Ala Ser Leu Ser Leu Cys Ala Pro Ala Ile Gly Gln Ala

50 55 60Ala Gly Arg Ala Ala Phe Thr Leu Glu Ala Gly Ala Glu Leu Asp Ala 65 70 75 80His Val Glu Ala Tyr Arg Glu Ala Arg Glu Val Phe Val Asp Lys Leu

85 90 95Pro Glu Ile Gly Leu Gly Thr Phe Ala Asp Pro Asp Gly Gly Leu Tyr

100 105 110Leu Trp Val Asp Val Ser Ala Tyr Thr Asp Asp Ser Glu Glu Trp Ala

115 120 125Leu Arg Leu Leu Asp Glu Ala Gly Val Ala Val Ala Pro Gly Val Asp

130 135 140Phe Asp Pro Glu Glu Gly His Lys Trp Ile Arg Leu Ser Leu Cys Ala145 150 155 160Ser Lys Glu Asp Thr Ile Glu Gly Val Arg Lys Ile Gly Glu Phe Ile

165170175 Lys Lys<210>489<211>385<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<385><223>FRXA00627<400>489gctgcattag agggtcgtat ctcgatctaa aagcagtacg cagataggct tgtctcttat 60gaagccaagc actagaagca atgttcagcc gtttcgcgtc atg cag atg ttg gac 115

Met Gln Met Leu Asp

1 5cga gtc cac cgt cgc agg cgc gaa ggc aaa gac acc tta atgttc tgc 163Arg Val His Arg Arg Arg Arg Glu Gly Lys Asp Thr Leu Met Phe Cys

10 15 20gct ggc cag ccg tca act ggt gcg cca gaa gca gtc atc gaa gaa gca 211Ala Gly Gln Pro Ser Thr Gly Ala Pro Glu Ala Val Ile Glu Glu Ala

25 30 35gag atc gct ctt cgc tcg ggt cct ttg gga tac acc gag gtg att ggt 259Glu Ile Ala Leu Arg Ser Gly Pro Leu Gly Tyr Thr Glu Val Ile Gly

40 45 50gat cgt gag ttc cgt gaa cgc atc gcc gat tgg cac tct gct act tat 307Asp Arg Glu Phe Arg Glu Arg Ile Ala Asp Trp His Ser Ala Thr Tyr

55 60 65gac gta gac acc aac cct gac aat gtt att gtc acc acc ggt tct tca 355Asp Val Asp Thr Asn Pro Asp Asn Val Ile Val Thr Thr Gly Ser Ser 70 75 80 85ggt gga ttc gtg gca tcg ttt atc gcc acc 385Gly Gly Phe Val Ala Ser Phe Ile Ala Thr

9095<210>490<211>95<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>490Met Gln Met Leu Asp Arg Val His Arg Arg Arg Arg Glu Gly Lys Asp 151015 Thr Leu Met Phe Cys Ala Gly Gln Pro Ser Thr Gly Ala Pro Glu Ala

20 25 30Val Ile Glu Glu Ala Glu Ile Ala Leu Arg Ser Gly Pro Leu Gly Tyr

35 40 45Thr Glu Val Ile Gly Asp Arg Glu Phe Arg Glu Arg Ile Ala Asp Trp

50 55 60His Ser Ala Thr Tyr Asp Val Asp Thr Asn Pro Asp Asn Val Ile Val 65 70 75 80Thr Thr Gly Ser Ser Gly Gly Phe Val Ala Ser Phe Ile Ala Thr

859095<210>491<211>1221<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1198)<223>RXS01105<400>491ttgtcatcaa ctttgccaac gccgaagatc ttccagcgca cggcgaagca atccgtgcac 60gctttgaaaa cctccccacc accgacgagg cctaagaaaa atg acc aaa att act 115

Met Thr Lys Ile Thr

1 5ttg agc gat ttg cca ttg cgt gaa gaa ctg cgc ggt gag cac gct tac 163Leu Ser Asp Leu Pro Leu Arg Glu Glu Leu Arg Gly Glu His Ala Tyr

10 15 20ggc gca ccc cag ctc aac gtt gat att cgc ctc aac acc aac gaa aac 211Gly Ala Pro Gln Leu Asn Val Asp Ile Arg Leu Asn Thr Asn Glu Asn

25 30 35cct tac cca ccg tca gag gca ttg gtc gct gac ttg gtt gcc acc gtg 259Pro Tyr Pro Pro Ser Glu Ala Leu Val Ala Asp Leu Val Ala Thr Val

40 45 50gat aag atc gcc acc gag ctg aac cgc tac cca gag cgc gat gct gtg 307Asp Lys Ile Ala Thr Glu Leu Asn Arg Tyr Pro Glu Arg Asp Ala Val

55 60 65gaa ctg cgt gat gag ttg gct gcg tac atc acc aag caa acc ggc gtg 355Glu Leu Arg Asp Glu Leu Ala Ala Tyr Ile Thr Lys Gln Thr Gly Val 70 75 80 85gct gtc acc agg gat aac ctg tgg gct gcc aat ggt tcc aat gaa att 403Ala Val Thr Arg Asp Asn Leu Trp Ala Ala Asn Gly Ser Asn Glu Ile

90 95 100ctg cag cag ctg ctg cag gct ttt ggt gga cct gga cgc acc gcg ttg 451Leu Gln Gln Leu Leu Gln Ala Phe Gly Gly Pro Gly Arg Thr Ala Leu

105 110 115gga ttc caa ccc agc tat tcc atg cac cca att ttg gct aaa ggc acc 499Gly Phe Gln Pro Ser Tyr Ser Met His Pro Ile Leu Ala Lys Gly Thr

120 125 130cac act gaa ttc att gcg gtg tcc cga ggt gct gat ttc cgc atc gat 547His Thr Glu Phe Ile Ala Val Ser Arg Gly Ala Asp Phe Arg Ile Asp

135 140 145atg gat gtg gcg ctg gaa gaa att cgt gca aag cag cct gac att gtt 595Met Asp Val Ala Leu Glu Glu Ile Arg Ala Lys Gln Pro Asp Ile Val150 155 160 165ttt gtc acc acc ccg aac aac ccg acc ggt gat gtg acc tcg ctg gac 643Phe Val Thr Thr Pro Asn Asn Pro Thr Gly Asp Val Thr Ser Leu Asp

170 175 180gat gtt gag cgc atc atc aac gtt gcc cca ggc atc gtg atc gtg gat 691Asp Val Glu Arg Ile Ile Asn Val Ala Pro Gly Ile Val Ile Val Asp

185 190 195gaa gct tat gcg gaa ttc tcc cca tca cct tca gca acc act ctt ctg 739Glu Ala Tyr Ala Glu Phe Ser Pro Ser Pro Ser Ala Thr Thr Leu Leu

200 205 210gag aag tac cca acc aag ctg gtg gtg tcc cgc acc atg agt aag gct 787Glu Lys Tyr Pro Thr Lys Leu Val Val Ser Arg Thr Met Ser Lys Ala

215 220 225ttt gat ttc gca ggt gga cgc ctc ggc tac ttc gtg gcc aac cca gcg 835Phe Asp Phe Ala Gly Gly Arg Leu Gly Tyr Phe Val Ala Asn Pro Ala230 235 240 245ttt atc gac gcc gtg atg cta gtc cgc ctt ccg tat cat ctt tca gcg 883Phe Ile Asp Ala Val Met Leu Val Arg Leu Pro Tyr His Leu Ser Ala

250 255 260ctg agc caa gca gcc gca atc gta gcg ctg cgt cac tcc gctgac acg 931Leu Ser Gln Ala Ala Ala Ile Val Ala Leu Arg His Ser Ala Asp Thr

265 270 275ctg gga acc gtc gaa aag ctc tct gta gag cgt gtt cgc gtg gca gca 979Leu Gly Thr Val Glu Lys Leu Ser Val Glu Arg Val Arg Val Ala Ala

280 285 290cgc ttg gag gaa ctg ggc tac gct gtg gtt cca agt gag tcc aac ttt 1027Arg Leu Glu Glu Leu Gly Tyr Ala Val Val Pro Ser Glu Ser Asn Phe

295 300 305gtg ttc ttt gga gat ttc tcc gat cag cac gcg gca tgg cag gca ttt 1075Val Phe Phe Gly Asp Phe Ser Asp Gln His Ala Ala Trp Gln Ala Phe310 315 320 325ttg gat agg gga gtg ctc atc cgc gat gtg gga atc gct ggg cac ttg 1123Leu Asp Arg Gly Val Leu Ile Arg Asp Val Gly Ile Ala Gly His Leu

330 335 340cgc act acc att ggt gtg cct gag gaa aat gat gcg ttt ttg gac gca 1171Arg Thr Thr Ile Gly Val Pro Glu Glu Asn Asp Ala Phe Leu Asp Ala

345 350 355gct gca gag atc atc aag ctg aac ctg taagagagaa gaatttttca 1218Ala Ala Glu Ile Ile Lys Leu Asn Leu

360365 tga 1221<210>492<211>366<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>492Met Thr Lys Ile Thr Leu Ser Asp Leu Pro Leu Arg Glu Glu Leu Arg 151015 Gly Glu His Ala Tyr Gly Ala Pro Gln Leu Asn Val Asp Ile Arg Leu

20 25 30Asn Thr Asn Glu Asn Pro Tyr Pro Pro Ser Glu Ala Leu Val Ala Asp

35 40 45Leu Val Ala Thr Val Asp Lys Ile Ala Thr Glu Leu Asn Arg Tyr Pro

50 5560Glu Arg Asp Ala Val Glu Leu Arg Asp Glu Leu Ala Ala Tyr Ile Thr 65 70 75 80Lys Gln Thr Gly Val Ala Val Thr Arg Asp Asn Leu Trp Ala Ala Asn

85 90 95Gly Ser Asn Glu Ile Leu Gln Gln Leu Leu Gln Ala Phe Gly Gly Pro

100 105 1l0Gly Arg Thr Ala Leu Gly Phe Gln Pro Ser Tyr Ser Met His Pro Ile

115 120 125Leu Ala Lys Gly Thr His Thr Glu Phe Ile Ala Val Ser Arg Gly Ala

130 135 140Asp Phe Arg Ile Asp Met Asp Val Ala Leu Glu Glu Ile Arg Ala Lys145 150 155 160Gln Pro Asp Ile Val Phe Val Thr Thr Pro Asn Asn Pro Thr Gly Asp

165 170 175Val Thr Ser Leu Asp Asp Val Glu Arg Ile Ile Asn Val Ala Pro Gly

180 185 190Ile Val Ile Val Asp Glu Ala Tyr Ala Glu Phe Ser Pro Ser Pro Ser

195 200 205Ala Thr Thr Leu Leu Glu Lys Tyr Pro Thr Lys Leu Val Val Ser Arg

210 215 220Thr Met Ser Lys Ala Phe Asp Phe Ala Gly Gly Arg Leu Gly Tyr Phe225 230 235 240Val Ala Asn Pro Ala Phe Ile Asp Ala Val Met Leu Val Arg Leu Pro

245 250 255Tyr His Leu Ser Ala Leu Ser Gln Ala Ala Ala Ile Val Ala Leu Arg

260 265 270His Ser Ala Asp Thr Leu Gly Thr Val Glu Lys Leu Ser Val Glu Arg

275280 285Val Arg Val Ala Ala Arg Leu Glu Glu Leu Gly Tyr Ala Val Val Pro

290 295 300Ser Glu Ser Asn Phe Val Phe Phe Gly Asp Phe Ser Asp Gln His Ala305 310 315 320Ala Trp Gln Ala Phe Leu Asp Arg Gly Val Leu Ile Arg Asp Val Gly

325 330 335Ile Ala Gly His Leu Arg Thr Thr Ile Gly Val Pro Glu Glu Asn Asp

340 345 350Ala Phe Leu Asp Ala Ala Ala Glu Ile Ile Lys Leu Asn Leu

355360365<210>493<211>1752<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1729)<223>RXS02315<400>493cgtttggaaa cgcttgctgc cagcaaagat aggcgtgatt ggtggtttga gcgcgtgcgt 60gaatcgtatc cgtacctgga gacgatctag actgttgtgc atg tcc agc acg cca 115

Met Ser Ser Thr Pro

1 5gct caa gat ctt gcc cgc gcc gtt att gat tcc ctc gca cca cac gtc 163Ala Gln Asp Leu Ala Arg Ala Val Ile Asp Ser Leu Ala Pro His Val

10 15 20act gac gtg gtg tta tgc cca gga tcc agg aac tca ccg ttg tcg ctt 211Thr Asp Val Val Leu Cys Pro Gly Ser Arg Asn Ser Pro Leu Ser Leu

25 30 35gag ttg ctg gcg cgg cag gat ctg cgt gtc cat gtg cgt atc gac gag 259Glu Leu Leu Ala Arg Gln Asp Leu Arg Val His Val Arg Ile Asp Glu

40 45 50cgc agc gcc tca ttt ttg gcg ctg tcc cta gcg cgt acc cag gcc cgg 307Arg Ser Ala Ser Phe Leu Ala Leu Ser Leu Ala Arg Thr Gln Ala Arg

55 60 65ccg gtg gct gtg gtg atg acc tcc ggc acg gct gta gct aac tgc ctg 355Pro Val Ala Val Val Met Thr Ser Gly Thr Ala Val Ala Asn Cys Leu 70 75 80 85cct gct gtt gct gaa gct gcg cat gcc cat atc ccg ttg att gtg ctc 403Pro Ala Val Ala Glu Ala Ala His Ala His Ile Pro Leu Ile Val Leu

90 95 100tct gct gac cgt cct gca cat ttg gtg gga acg ggg gcg agc caa acg 451Ser Ala Asp Arg Pro Ala His Leu Val Gly Thr Gly Ala Ser Gln Thr

105 110 115att aac cag acc ggt att ttt ggt gat ctt gca ccg acg gtc ggt atc 499Ile Asn Gln Thr Gly Ile Phe Gly Asp Leu Ala Pro Thr Val Gly Ile

120 125 130act gag ctg gat cag gta gcg cag att gct gaa agc ctt gct cag ggg 547Thr Glu Leu Asp Gln Val Ala Gln Ile Ala Glu Ser Leu Ala Gln Gly

135 140 145gct tcc cag att ccg cgt cat ttc aat ctt gca ctt gat gtt cct ttg 595Ala Ser Gln Ile Pro Arg His Phe Asn Leu Ala Leu Asp Val Pro Leu150 155 160 165gtt gct cct gaa ctg cca gag ctt cat ggt gag gca gtt gga gca tca 643Val Ala Pro Glu Leu Pro Glu Leu His Gly Glu Ala Val Gly Ala Ser

170 175 180tgg acg cat cgc tgg atc aac cac ggt gag gtg acc gtg gac ctg ggg 691Trp Thr His Arg Trp Ile Asn His Gly Glu Val Thr Val Asp Leu Gly

185 190 195gag cac acc ctc gtg att gcc ggt gat gaa gca tgg gaa gtg gaa ggg 739Glu His Thr Leu Val Ile Ala Gly Asp Glu Ala Trp Glu Val Glu Gly

200 205 210ctg gaa gat gtg ccc acc atc gct gaa cct act gca cca aag cct tat 787Leu Glu Asp Val Pro Thr Ile Ala Glu Pro Thr Ala Pro Lys Pro Tyr

215 220 225aat ccg gtg cac cca ctg gct gct gaa atc ttg ctg aag gag cag gtc 835Asn Pro Val His Pro Leu Ala Ala Glu Ile Leu Leu Lys Glu Gln Val230 235 240 245tcc gcg gaa ggc tat gtg gta aac acc agg cct gat cat gtg atc gtg 883Ser Ala Glu Gly Tyr Val Val Asn Thr Arg Pro Asp His Val Ile Val

250 255 260gtg gga cac ccc acg ctg cac cgc gga gtg ttg aag ttg atg tca gat 931Val Gly His Pro Thr Leu His Arg Gly Val Leu Lys Leu Met Ser Asp

265 270 275cct ggc att aaa tta act gtg ctt tca cgc acc gat atc atc act gat 979Pro Gly Ile Lys Leu Thr Val Leu Ser Arg Thr Asp Ile Ile Thr Asp

280 285 290ccc ggc cgc cat gcc gat cag gtg ggc agc aca gtg aaa gtc acc ggc 1027Pro Gly Arg His Ala Asp Gln Val Gly Ser Thr Val Lys Val Thr Gly

295 300 305acc cag gaa aag cag tgg cta aag atc tgt tcg gca gca tca gaa ctt 1075Thr Gln Glu Lys Gln Trp Leu Lys Ile Cys Ser Ala Ala Ser Glu Leu310 315 320 325gcg gcc gat ggt gtg cgt gac gtc ctg gac aac caa gaa ttc ggt ttc 1123Ala Ala Asp Gly Val Arg Asp Val Leu Asp Asn Gln Glu Phe Gly Phe

330 335 340acc ggc ctc cat gtt gcc gca gcc gtg gcg gat acc tta ggc acc ggc 1171Thr Gly Leu His Val Ala Ala Ala Val Ala Asp Thr Leu Gly Thr Gly

345 350 355gat act ctc ttt gct gca gca tcc aac tca atc cgt gac ctc tcc ctg 1219Asp Thr Leu Phe Ala Ala Ala Ser Asn Ser Ile Arg Asp Leu Ser Leu

360 365 370gtg ggt atg cct ttt gat ggc gtg gat acc ttc tcc cca cga ggt gtc 1267Val Gly Met Pro Phe Asp Gly Val Asp Thr Phe Ser Pro Arg Gly Val

375 380 385gca ggc att gat ggt tct gtt gct caa gca atc ggc act tca ctt gct 1315Ala Gly Ile Asp Gly Ser Val Ala Gln Ala Ile Gly Thr Ser Leu Ala390 395 400 405gtg cag tcc cgc cac ccc gat gaa atc cgc gcg cca cgc act gtg gcc 1363Val Gln Ser Arg His Pro Asp Glu Ile Arg Ala Pro Arg Thr Val Ala

410 415 420ctt ctg ggc gat ctg tcg ttc ctt cac gat att ggc gga ctg ctc atc 1411Leu Leu Gly Asp Leu Ser Phe Leu His Asp Ile Gly Gly Leu Leu Ile

425 430 435ggc cct gat gaa cca cgc cca gaa aac ctc acc atc gtg gtc tcc aac 1459Gly Pro Asp Glu Pro Arg Pro Glu Asn Leu Thr Ile Val Val Ser Asn

440 445 450gac aac ggt ggc gga atc ttc gaa ctc cta gaa acc ggc gca gat ggt 1507Asp Asn Gly Gly Gly Ile Phe Glu Leu Leu Glu Thr Gly Ala Asp Gly

455 460 465ctc cgc ccc aac ttc gag cgt gct ttc ggt acc cca cac gac gcg tcc 1555Leu Arg Pro Asn Phe Glu Arg Ala Phe Gly Thr Pro His Asp Ala Ser470 475 480 485atc gcg gat ctc tgc gca ggc tac ggc att gaa cac caa gtg gta gac 1603Ile Ala Asp Leu Cys Ala Gly Tyr Gly Ile Glu His Gln Val Val Asp

490 495 500aac ctc caa gac ctc atc atc gcg cta gtt gat acc acc gaa gta tcc 1651Asn Leu Gln Asp Leu Ile Ile Ala Leu Val Asp Thr Thr Glu Val Ser

505 510515gga ttc acc att att gaa gct tcg acc gtc cga gat acc cgc cgt gca 1699Gly Phe Thr Ile Ile Glu Ala Ser Thr Val Arg Asp Thr Arg Arg Ala

520 525 530caa cag caa gct ctc atg gac acg gtg cac taaatggagt ggtaccaagt 1749Gln Gln Gln Ala Leu Met Asp Thr Val His

535540 gcg 1752<210>494<211>543<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>494Met Ser Ser Thr Pro Ala Gln Asp Leu Ala Arg Ala Val Ile Asp Ser 151015 Leu Ala Pro His Val Thr Asp Val Val Leu Cys Pro Gly Ser Arg Asn

20 25 30Ser Pro Leu Ser Leu Glu Leu Leu Ala Arg Gln Asp Leu Arg Val His

35 40 45Val Arg Ile Asp Glu Arg Ser Ala Ser Phe Leu Ala Leu Ser Leu Ala

50 55 60Arg Thr Gln Ala Arg Pro Val Ala Val Val Met Thr Ser Gly Thr Ala 65 70 75 80Val Ala Asn Cys Leu Pro Ala Val Ala Glu Ala Ala His Ala His Ile

85 90 95Pro Leu Ile Val Leu Ser Ala Asp Arg Pro Ala His Leu Val Gly Thr

100 105 110Gly Ala Ser Gln Thr Ile Asn Gln Thr Gly Ile Phe Gly Asp Leu Ala

115 120 125Pro Thr Val Gly Ile Thr Glu Leu Asp Gln Val Ala Gln Ile Ala Glu

130 135 140Ser Leu Ala Gln Gly Ala Ser Gln Ile Pro Arg His Phe Asn Leu Ala145 150 155 160Leu Asp Val Pro Leu Val Ala Pro Glu Leu Pro Glu Leu His Gly Glu

165 170175Ala Val Gly Ala Ser Trp Thr His Arg Trp Ile Asn His Gly Glu Val

180 185 190Thr Val Asp Leu Gly Glu His Thr Leu Val Ile Ala Gly Asp Glu Ala

195 200 205Trp Glu Val Glu Gly Leu Glu Asp Val Pro Thr Ile Ala Glu Pro Thr

210 215 220Ala Pro Lys Pro Tyr Asn Pro Val His Pro Leu Ala Ala Glu Ile Leu225 230 235 240Leu Lys Glu Gln Val Ser Ala Glu Gly Tyr Val Val Asn Thr Arg Pro

245 250 255Asp His Val Ile Val Val Gly His Pro Thr Leu His Arg Gly Val Leu

260 265 270Lys Leu Met Ser Asp Pro Gly Ile Lys Leu Thr Val Leu Ser Arg Thr

275 280 285Asp Ile Ile Thr Asp Pro Gly Arg His Ala Asp Gln Val Gly Ser Thr

290 295 300Val Lys Val Thr Gly Thr Gln Glu Lys Gln Trp Leu Lys Ile Cys Ser305 310 315 320Ala Ala Ser Glu Leu Ala Ala Asp Gly Val Arg Asp Val Leu Asp Asn

325 330 335Gln Glu Phe Gly Phe Thr Gly Leu His Val Ala Ala Ala Val Ala Asp

340 345 350Thr Leu Gly Thr Gly Asp Thr Leu Phe Ala Ala Ala Ser Asn Ser Ile

355 360 365Arg Asp Leu Ser Leu Val Gly Met Pro Phe Asp Gly Val Asp Thr Phe

370 375 380Ser Pro Arg Gly Val Ala Gly Ile Asp Gly Ser Val Ala Gln Ala Ile385 390 395400Gly Thr Ser Leu Ala Val Gln Ser Arg His Pro Asp Glu Ile Arg Ala

405 410 415Pro Arg Thr Val Ala Leu Leu Gly Asp Leu Ser Phe Leu His Asp Ile

420 425 430Gly Gly Leu Leu Ile Gly Pro Asp Glu Pro Arg Pro Glu Asn Leu Thr

435 440 445Ile Val Val Ser Asn Asp Asn Gly Gly Gly Ile Phe Glu Leu Leu Glu

450 455 460Thr Gly Ala Asp Gly Leu Arg Pro Asn Phe Glu Arg Ala Phe Gly Thr465 470 475 480Pro His Asp Ala Ser Ile Ala Asp Leu Cys Ala Gly Tyr Gly Ile Glu

485 490 495His Gln Val Val Asp Asn Leu Gln Asp Leu Ile Ile Ala Leu Val Asp

500 505 510Thr Thr Glu Val Ser Gly Phe Thr Ile Ile Glu Ala Ser Thr Val Arg

515 520 525Asp Thr Arg Arg Ala Gln Gln Gln Ala Leu Met Asp Thr Val His

530535540<210>495<211>1434<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1411)<223>RXS02550<400>495gatcttaggc agccgtggga ttacaccctt ttagagctag aacagtaaaa attcacccaa 60tagctttcaa ctacgcacac aaagtggcaa cattgagcgg gtg act aca gac aag 115

Val Thr Thr Asp Lys

1 5cgc aaa acc tct aag acc acc gac acc gcc aac aag gct gtg ggc gcg 163Arg Lys Thr ser Lys Thr Thr Asp Thr Ala Asn Lys Ala Val Gly Ala

10 15 20gat cag gca gcg cgt ccc act cgg cga aca act cgc cgc atc ttc gat 211Asp Gln Ala Ala Arg Pro Thr Arg Arg Thr Thr Arg Arg Ile Phe Asp

25 30 35cag tcg gag aag atg aag gac gtg ctg tac gag atc cgt ggc ccg gtg 259Gln Ser Glu Lys Met Lys Asp Val Leu Tyr Glu Ile Arg Gly Pro Val

40 45 50gcc gcg gag gcg gaa cgc atg gag ctt gat ggg cat aac atc tta aag 307Ala Ala Glu Ala Glu Arg Met Glu Leu Asp Gly His Asn Ile Leu Lys

55 60 65ctc aac acg gga aat cca gcc gtg ttc gga ttc gat gcc ccc gac gtg 355Leu Asn Thr Gly Asn Pro Ala Val Phe Gly Phe Asp Ala Pro Asp Val 70 75 80 85att atg cgt gac atg atc gcc aac ctt cca act tcc caa ggg tat tcc 403Ile Met Arg Asp Met Ile Ala Asn Leu Pro Thr Ser Gln Gly Tyr Ser

90 95 100acc tcc aaa ggc att att ccg gcc cgg cga gca gtg gtc acc cgc tac 451Thr Ser Lys Gly Ile Ile Pro Ala Arg Arg Ala Val Val Thr Arg Tyr

105 110 115gaa gtt gtg ccc gga ttc ccc cac ttc gat gtt gat gat gtg ttc tta 499Glu Val Val Pro Gly Phe Pro His Phe Asp Val Asp Asp Val Phe Leu

120 125 130ggc aac ggt gtc tca gaa cta atc acc atg acc acc caa gca ctc ctc 547Gly Asn Gly Val Ser Glu Leu Ile Thr Met Thr Thr Gln Ala Leu Leu

135 140 145aac gac ggc gat gaa gtt ctt atc ccc gca ccg gac tac cca ctg tgg 595Asn Asp Gly Asp Glu Val Leu Ile Pro Ala Pro Asp Tyr Pro Leu Trp150 155 160 165act gcc gca acc tcc ctg gct ggt ggt aag cct gtg cac tacctc tgt 643Thr Ala Ala Thr Ser Leu Ala Gly Gly Lys Pro Val His Tyr Leu Cys

170 175 180gat gag gaa gat gac tgg aac cca tcc atc gaa gac atc aag tcc aaa 691Asp Glu Glu Asp Asp Trp Asn Pro Ser Ile Glu Asp Ile Lys Ser Lys

185 190 195atc tca gag aaa acc aaa gct att gtg gtg atc aac ccc aac aac ccc 739Ile Ser Glu Lys Thr Lys Ala Ile Val Val Ile Asn Pro Asn Asn Pro

200 205 210acg gga gct gtc tac ccg cgc cgg gtg ttg gaa caa atc gtc gag att 787Thr Gly Ala Val Tyr Pro Arg Arg Val Leu Glu Gln Ile Val Glu Ile

215 220 225gca cgc gag cat gac ctg ctg att ttg gcc gat gaa atc tac gac cgc 835Ala Arg Glu His Asp Leu Leu Ile Leu Ala Asp Glu Ile Tyr Asp Arg230 235 240 245att ctc tac gat gat gcc gag cac atc agc ctg gca acc ctt gca cca 883Ile Leu Tyr Asp Asp Ala Glu His Ile Ser Leu Ala Thr Leu Ala Pro

250 255 260gat ctc ctt tgc atc aca tac aac ggt cta tcc aag gca tac cgc gtc 931Asp Leu Leu Cys Ile Thr Tyr Asn Gly Leu Ser Lys Ala Tyr Arg Val

265 270 275gca gga tac cga gct ggc tgg atg gta ttg act gga cca aag caa tac 979Ala Gly Tyr Arg Ala Gly Trp Met Val Leu Thr Gly Pro Lys Gln Tyr

280 285 290gca cgt gga ttt att gag ggc ctc gaa ctc ctc gca ggc act cga ctc 1027Ala Arg Gly Phe Ile Glu Gly Leu Glu Leu Leu Ala Gly Thr Arg Leu

295 300 305tgc cca aat gtc cca gct cag cac gct att cag gta gct ctg ggt gga 1075Cys Pro Asn Val Pro Ala Gln His Ala Ile Gln Val Ala Leu GlyGly310 315 320 325cgc cag tcc atc tac gac ctc act ggc gaa cac ggc cga ctc ctg gaa 1123Arg Gln Ser Ile Tyr Asp Leu Thr Gly Glu His Gly Arg Leu Leu Glu

330 335 340cag cgc aac atg gca tgg acg aaa ctc aac gaa atc cca ggt gtc agc 1171Gln Arg Asn Met Ala Trp Thr Lys Leu Asn Glu Ile Pro Gly Val Ser

345 350 355tgt gtg aaa cca atg gga gct cta tac gcg ttc ccc aag ctc gac ccc 1219Cys Val Lys Pro Met Gly Ala Leu Tyr Ala Phe Pro Lys Leu Asp Pro

360 365 370aac gtg tac gaa atc cac gac gac acc caa ctc atg ctg gat ctt ctc 1267Asn Val Tyr Glu Ile His Asp Asp Thr Gln Leu Met Leu Asp Leu Leu

375 380 385cgt gcc gag aaa atc ctc atg gtt cag ggc act ggc ttc aac tgg cca 1315Arg Ala Glu Lys Ile Leu Met Val Gln Gly Thr Gly Phe Asn Trp Pro390 395 400 405cat cac gat cac ttc cga gtg gtc acc ctg cca tgg gca tcc cag ttg 1363His His Asp His Phe Arg Val Val Thr Leu Pro Trp Ala Ser Gln Leu

410 415 420gaa aac gca att gag cgc ctg ggt aac ttc ctg tcc act tac aag cag 1411Glu Asn Ala Ile Glu Arg Leu Gly Asn Phe Leu Ser Thr Tyr Lys Gln

425430435 tagtagttgt taggattcac cac 1434<210>496<211>437<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>496Val Thr Thr Asp Lys Arg Lys Thr Ser Lys Thr Thr Asp Thr Ala Asn 151015 Lys Ala Val Gly Ala Asp Gln Ala Ala Arg Pro Thr Arg Arg Thr Thr

20 25 30Arg Arg Ile Phe Asp Gln Ser Glu Lys Met Lys Asp Val Leu Tyr Glu

35 40 45Ile Arg Gly Pro Val Ala Ala Glu Ala Glu Arg Met Glu Leu Asp Gly

50 55 60His Asn Ile Leu Lys Leu Asn Thr Gly Asn Pro Ala Val Phe Gly Phe 65 70 75 80Asp Ala Pro Asp Val Ile Met Arg Asp Met Ile Ala Asn Leu Pro Thr

85 90 95Ser Gln Gly Tyr Ser Thr Ser Lys Gly Ile Ile Pro Ala Arg Arg Ala

100 105 110Val Val Thr Arg Tyr Glu Val Val Pro Gly Phe Pro His Phe Asp Val

115 120 125Asp Asp Val Phe Leu Gly Asn Gly Val Ser Glu Leu Ile Thr Met Thr

130 135 140Thr Gln Ala Leu Leu Asn Asp Gly Asp Glu Val Leu Ile Pro Ala Pro145 150 155 160Asp Tyr Pro Leu Trp Thr Ala Ala Thr Ser Leu Ala Gly Gly Lys Pro

165 170 175Val His Tyr Leu Cys Asp Glu Glu Asp Asp Trp Asn Pro Ser Ile Glu

180 185 190Asp Ile Lys Ser Lys Ile Ser Glu Lys Thr Lys Ala Ile Val Val Ile

195 200 205Asn Pro Asn Asn Pro Thr Gly Ala Val Tyr Pro Arg Arg Val Leu Glu

210 215 220Gln Ile Val Glu Ile Ala Arg Glu His Asp Leu Leu Ile Leu Ala Asp225 230 235 240Glu Ile Tyr Asp Arg Ile Leu Tyr Asp Asp Ala Glu His Ile Ser Leu

245 250 255Ala Thr Leu Ala Pro Asp Leu Leu Cys Ile Thr Tyr Asn Gly Leu Ser

260 265 270Lys Ala Tyr Arg Val Ala Gly Tyr Arg Ala Gly Trp Met Val Leu Thr

275 280 285Gly Pro Lys Gln Tyr Ala Arg Gly Phe Ile Glu Gly Leu Glu Leu Leu

290 295 300Ala Gly Thr Arg Leu Cys Pro Asn Val Pro Ala Gln His Ala Ile Gln305 310 315 320Val Ala Leu Gly Gly Arg Gln Ser Ile Tyr Asp Leu Thr Gly Glu His

325 330 335Gly Arg Leu Leu Glu Gln Arg Asn Met Ala Trp Thr Lys Leu Asn Glu

340 345 350Ile Pro Gly Val Ser Cys Val Lys Pro Met Gly Ala Leu Tyr Ala Phe

355 360 365Pro Lys Leu Asp Pro Asn Val Tyr Glu Ile His Asp Asp Thr Gln Leu

370 375 380Met Leu Asp Leu Leu Arg Ala Glu Lys Ile Leu Met Val Gln Gly Thr385 390 395 400Gly Phe Asn Trp Pro His His Asp His Phe Arg Val Val Thr Leu Pro

405 410 415Trp Ala Ser Gln Leu Glu Asn Ala Ile Glu Arg Leu Gly Asn Phe Leu

420 425 430Ser Thr Tyr Lys Gln

435<210>497<211>1080<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1057)<223>RXS02319<400>497atgtgggtga gataaccgac cgtgatgtcg ccctagcaaa agtcatcgac gcccacgcca 60agaccttggc catttcggca gaggcttaag gttaaagatt atg agc aac tac agc 115

Met Ser Asn Tyr Ser

1 5acc gac aac cct ttt gat ccc acc caa tgg gcc acc gtt cca ggt ttt 163Thr Asp Asn Pro Phe Asp Pro Thr Gln Trp Ala Thr Val Pro Gly Phe

10 15 20gaa gaa ttc acc gac atc acc tac cac cgc cac gtg ggc acc acc cgc 211Glu Glu Phe Thr Asp Ile Thr Tyr His Arg His Val Gly Thr Thr Arg

25 30 35gcc gat ggc atc gtg cgc atc gcc ttc gac cgc ccc gaa gtt cgc aat 259Ala Asp Gly Ile Val Arg Ile Ala Phe Asp Arg Pro Glu Val Arg Asn

40 45 50gct ttc cgc ccc cac acc gtc gac gag ctt tac caa gcc ctc gac cac 307Ala Phe Arg Pro His Thr Val Asp Glu Leu Tyr Gln Ala Leu Asp His

55 60 65gcg cgc cgg acc cca gat gtt gga acc atc ctg ctc acc ggc aac ggc 355Ala Arg Arg Thr Pro Asp Val Gly Thr Ile Leu Leu Thr Gly Asn Gly 70 75 80 85ccc agc gaa aaa gac ggt ggc tgg gcg ttc tgc tcc ggc ggc gac caa 403Pro Ser Glu Lys Asp Gly Gly Trp Ala Phe Cys Ser Gly Gly Asp Gln

90 95 100cgc atc cgc ggg cgc tcc ggc tac caa tac gcc acc gaa cac gcg cgc 451Arg Ile Arg Gly Arg Ser Gly Tyr Gln Tyr Ala Thr Glu His Ala Arg

105 110 115gac gat gcc acc gct gat gtc ttc acg gta gat att gcc cgc acc aaa 499Asp Asp Ala Thr Ala Asp Val Phe Thr Val Asp Ile Ala Arg Thr Lys

120 125 130gtt gaa ggc gga cgc ctc cac att ttg gaa gtc caa cgc ctc atc cgc 547Val Glu Gly Gly Arg Leu His Ile Leu Glu Val Gln Arg Leu Ile Arg

135 140145acc atg cct aaa gtt gtc atc gca gta gtc aac ggc tgg gca gcc ggc 595Thr Met Pro Lys Val Val Ile Ala Val Val Asn Gly Trp Ala Ala Gly150 155 160 165ggt ggg cac tcc ctc cat gtc gtt tgc gac ctc acc atc gct tcc cgc 643Gly Gly His Ser Leu His Val Val Cys Asp Leu Thr Ile Ala Ser Arg

170 175 180caa gaa gca cgc ttc aag caa acc gac gct gac gtg gga tcc ttc gac 691Gln Glu Ala Arg Phe Lys Gln Thr Asp Ala Asp Val Gly Ser Phe Asp

185 190 195gct ggc tac ggc tcc gcc tac cta gcg aaa atg gtc gga cag aaa aac 739Ala Gly Tyr Gly Ser Ala Tyr Leu Ala Lys Met Val Gly Gln Lys Asn

200 205 210gcc cgc gaa atc ttc ttc ctc gga cgc acc tac gac gcc gaa cgc atg 787Ala Arg Glu Ile Phe Phe Leu Gly Arg Thr Tyr Asp Ala Glu Arg Met

215 220 225caa caa atg ggc gca gtc aac atc gtg gcc gac cac ggc gac cta gaa 835Gln Gln Met Gly Ala Val Asn Ile Val Ala Asp His Gly Asp Leu Glu230 235 240 245aaa gaa gcc atc caa gca gcc cgc gaa atc aac acc aaa tcc ccc acc 883Lys Glu Ala Ile Gln Ala Ala Arg Glu Ile Asn Thr Lys Ser Pro Thr

250 255 260ggg caa cgc atg ctg aaa ttc gcc ttc aat ctc acc gac gat ggc ctc 931Gly Gln Arg Met Leu Lys Phe Ala Phe Asn Leu Thr Asp Asp Gly Leu

265 270 275atg gga caa caa gtc ttc gcc ggc gaa gcc acc cgc ctg gcc tac atg 979Met Gly Gln Gln Val Phe Ala Gly Glu Ala Thr Arg Leu Ala Tyr Met

280 285 290acg gat gaa gcc gta gag ggt aag gaa gca ttc cta gaa aag cgc gaa 1027Thr Asp Glu AlaVal Glu Gly Lys Glu Ala Phe Leu Glu Lys Arg Glu

295300305 ccc aac tgg aat gaa ttc cct tac tac tac tagtgagttc atggggtcct 1077Pro Asn Trp Asn Glu Phe Pro Tyr Tyr Tyr 310315 aaa 1080<210>498<211>319<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>498Met Ser Asn Tyr Ser Thr Asp Asn Pro Phe Asp Pro Thr Gln Trp Ala 151015 Thr Val Pro Gly Phe Glu Glu Phe Thr Asp Ile Thr Tyr His Arg His

20 25 30Val Gly Thr Thr Arg Ala Asp Gly Ile Val Arg Ile Ala Phe Asp Arg

35 40 45Pro Glu Val Arg Asn Ala Phe Arg Pro His Thr Val Asp Glu Leu Tyr

50 55 60Gln Ala Leu Asp His Ala Arg Arg Thr Pro Asp Val Gly Thr Ile Leu 65 70 75 80Leu Thr Gly Asn Gly Pro Ser Glu Lys Asp Gly Gly Trp Ala Phe Cys

85 90 95Ser Gly Gly Asp Gln Arg Ile Arg Gly Arg Ser Gly Tyr Gln Tyr Ala

100 105 110Thr Glu His Ala Arg Asp Asp Ala Thr Ala Asp Val Phe Thr Val Asp

115 120 125Ile Ala Arg Thr Lys Val Glu Gly Gly Arg Leu His Ile Leu Glu Val

130 135 140Gln Arg Leu Ile Arg Thr Met Pro Lys Val Val Ile Ala Val Val Asn145 150 155 160Gly Trp Ala Ala Gly Gly Gly His Ser Leu His Val Val Cys Asp Leu

165 170 175Thr Ile Ala Ser Arg Gln Glu Ala Arg Phe Lys Gln Thr Asp Ala Asp

180 185 190ValGly Ser Phe Asp Ala Gly Tyr Gly Ser Ala Tyr Leu Ala Lys Met

195 200 205Val Gly Gln Lys Asn Ala Arg Glu Ile Phe Phe Leu Gly Arg Thr Tyr

210 215 220Asp Ala Glu Arg Met Gln Gln Met Gly Ala Val Asn Ile Val Ala Asp225 230 235 240His Gly Asp Leu Glu Lys Glu Ala Ile Gln Ala Ala Arg Glu Ile Asn

245 250 255Thr Lys Ser Pro Thr Gly Gln Arg Met Leu Lys Phe Ala Phe Asn Leu

260 265 270Thr Asp Asp Gly Leu Met Gly Gln Gln Val Phe Ala Gly Glu Ala Thr

275 280 285Arg Leu Ala Tyr Met Thr Asp Glu Ala Val Glu Gly Lys Glu Ala Phe

290295300 Leu Glu Lys Arg Glu Pro Asn Trp Asn Glu Phe Pro Tyr Tyr Tyr 305310315<210>499<211>384<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) · (361)<223>RXS02908<400>499gccaacgagg gttggtttac cacctctgat tcaggtgaac tccacgacgg gattctcacc 60gtgactggtc gcgtggatac ccgtcattga ttccggtgga ttg aag ttg cac cca 115

Leu Lys Leu His Pro

1 5gag gta ctg gaa cgt gcc atc gca gat att aaa ggt gtc acc gcg gcg 163Glu Val Leu Glu Arg Ala Ile Ala Asp Ile Lys Gly Val Thr Ala Ala

10 15 20tgt gtt gtg ggt att ccc gat ccc cga tta ggc caa gca att gtg gcc 211Cys Val Val Gly Ile Pro Asp Pro Arg Leu Gly Gln Ala Ile Val Ala

25 3035gcg tac tcc gga tcg atc agt ccg tct gaa gtt att gaa ggc ctc gac 259Ala Tyr Ser Gly Ser Ile Ser Pro Ser Glu Val Ile Glu Gly Leu Asp

40 45 50gat cta cct cgt tgg cag ctt ccc aaa cgg ctg aag cat ctg gaa tct 307Asp Leu Pro Arg Trp Gln Leu Pro Lys Arg Leu Lys His Leu Glu Ser

556065 ttg ccc agc att ggt cct gga aaa gct gat cga cgt gct atc gcg aag 355Leu Pro Ser Ile Gly Pro Gly Lys Ala Asp Arg Arg Ala Ile Ala Lys 70758085 ctg ttt tagtcttcat tcttgctggc tgc 384Leu Phe<210>500<211>87<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>500Leu Lys Leu His Pro Glu Val Leu Glu Arg Ala Ile Ala Asp Ile Lys 151015 Gly Val Thr Ala Ala Cys Val Val Gly Ile Pro Asp Pro Arg Leu Gly

20 25 30Gln Ala Ile Val Ala Ala Tyr Ser Gly Ser Ile Ser Pro Ser Glu Val

35 40 45Ile Glu Gly Leu Asp Asp Leu Pro Arg Trp Gln Leu Pro Lys Arg Leu

50 55 60Lys His Leu Glu Ser Leu Pro Ser Ile Gly Pro Gly Lys Ala Asp Arg 65 70 75 80Arg Ala Ile Ala Lys Leu Phe

85<210>501<211>775<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (775)<223>RXS03003<400>501tcgatgatct gggctcccca ggtggtgcgg ctaagcttgg accacaagat tttgatcacc 60caatgatcgc tgcgctgccg cctcaggcat aatctaacgc atg acc tct cgc acc 115

Met Thr Ser Arg Thr

1 5ccg ctt gtt tct gtt ctt cct gat ttt ccg tgggat tcg ctc gct tcc 163Pro Leu Val Ser Val Leu Pro Asp Phe Pro Trp Asp Ser Leu Ala Ser

10 15 20gca aaa gcc aaa gct gcg tct cac ccg gat ggg atc gtg aat ctt tct 211Ala Lys Ala Lys Ala Ala Ser His Pro Asp Gly Ile Val Asn Leu Ser

25 30 35gtt ggc act ccg gtt gat ccg gtc gcg ccc agc att cag atc gcg ttg 259Val Gly Thr Pro Val Asp Pro Val Ala Pro Ser Ile Gln Ile Ala Leu

40 45 50gca gaa gca gcg ggg ttt tcg ggt tac cct caa acc atc ggc acc ccg 307Ala Glu Ala Ala Gly Phe Ser Gly Tyr Pro Gln Thr Ile Gly Thr Pro

55 60 65gaa ctc cgc gca gcc atc agg ggc gcg ctt gag cgg cgc tac aac atg 355Glu Leu Arg Ala Ala Ile Arg Gly Ala Leu Glu Arg Arg Tyr Asn Met 70 75 80 85aca aag ctt gtc gac gcc tcc ctc ctc ccc gtc gtg ggt acc aag gag 403Thr Lys Leu Val Asp Ala Ser Leu Leu Pro Val Val Gly Thr Lys Glu

90 95 100gca att gcc ctt ctt cca ttc gcg ttg ggt att tcc ggc acc gtt gtc 451Ala Ile Ala Leu Leu Pro Phe Ala Leu Gly Ile Ser Gly Thr Val Val

105 110 115atc cca gag att gcg tac cca acc tac gaa gtc gct gtc gtg gcc gca 499Ile Pro Glu Ile Ala Tyr Pro Thr Tyr Glu Val Ala Val Val Ala Ala

120 125 130gga tgc acc gtg ttg cgt tct gat tcg ctg ttt aag ctc ggc ccg cag 547Gly Cys Thr Val Leu Arg Ser Asp Ser Leu Phe Lys Leu Gly Pro Gln

135 140 145atc ccg tcg atg atg ttt atc aac tca cca tcc aac ccc aca ggc aag 595Ile Pro Ser Met Met Phe Ile Asn Ser Pro Ser Asn Pro Thr Gly Lys150 155 160 165gtt ctg ggc atc cca cac ttg cgc aag gtt gtg aag tgg gcg cag gaa 643Val Leu Gly Ile Pro His Leu Arg Lys Val Val Lys Trp Ala Gln Glu

170 175 180aac aac gtg atc ctc gca gct gat gaa tgc tac ttg ggt ctt ggc tgg 691Asn Asn Val Ile Leu Ala Ala Asp Glu Cys Tyr Leu Gly Leu Gly Trp

185 190 195gac gat gaa aac cca ccg atc tca att ttg gat cca cgt gtc tgc gat 739Asp Asp Glu Asn Pro Pro Ile Ser Ile Leu Asp Pro Arg Val Cys Asp

200 205 210ggc gac cac acc aac ttg atc gcc att cac tcg ctg 775Gly Asp His Thr Asn Leu lle Ala Ile His Ser Leu

215220225<210>502<211>225<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>502Met Thr Ser Arg Thr Pro Leu Val Ser Val Leu Pro Asp Phe Pro Trp 151015 Asp Ser Leu Ala Ser Ala Lys Ala Lys Ala Ala Ser His Pro Asp Gly

20 25 30Ile Val Asn Leu Ser Val Gly Thr Pro Val Asp Pro Val Ala Pro Ser

35 40 45Ile Gln Ile Ala Leu Ala Glu Ala Ala Gly Phe Ser Gly Tyr Pro Gln

50 55 60Thr Ile Gly Thr Pro Glu Leu Arg Ala Ala Ile Arg Gly Ala Leu Glu 65 70 75 80Arg Arg Tyr Asn Met Thr Lys Leu Val Asp Ala Ser Leu Leu Pro Val

85 90 95Val Gly Thr Lys Glu Ala Ile Ala Leu Leu Pro Phe Ala Leu Gly Ile

100 105 110Ser Gly Thr Val Val Ile Pro Glu Ile Ala TyrPro Thr Tyr Glu Val

115 120 125Ala Val Val Ala Ala Gly Cys Thr Val Leu Arg Ser Asp Ser Leu Phe

130 135 140Lys Leu Gly Pro Gln Ile Pro Ser Met Met Phe Ile Asn Ser Pro Ser145 150 155 160Asn Pro Thr Gly Lys Val Leu Gly Ile Pro His Leu Arg Lys Val Val

165 170 175Lys Trp Ala Gln Glu Asn Asn Val Ile Leu Ala Ala Asp Glu Cys Tyr

180 185 190Leu Gly Leu Gly Trp Asp Asp Glu Asn Pro Pro Ile Ser Ile Leu Asp

195 200 205Pro Arg Val Cys Asp Gly Asp His Thr Asn Leu Ile Ala Ile His Ser

210215220 Leu225<210>503<211>390<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220>CDS<222>(101) · (367)<223>RXS03026<400>503gttggcggcg cagtatcgtg aggtgcggga cctcgagcgg ggaatcccaa actagcatcc 60cgaactagcc ccccaacaac aattagaaat ggaacctaaa atg cct gga aaa att 115

Met Pro Gly Lys Ile

1 5ctc ctt ctc aac ggc cca aac ctg aac atg ctg ggc aaa cgc gag cct 163Leu Leu Leu Asn Gly Pro Asn Leu Asn Met Leu Gly Lys Arg Glu Pro

10 15 20gac att tac gga cac gac acc ttg gaa gac gtc gtc gcg ctg gca acc 211Asp Ile Tyr Gly His Asp Thr Leu Glu Asp Val Val Ala Leu Ala Thr

25 30 35gct gag gct gcg aaa cac ggc ctt gag gtt gag gcg ctg cag agc aat 259Ala Glu Ala Ala Lys His Gly Leu Glu ValGlu Ala Leu Gln Ser Asn

40 45 50cac caa ggt gag cta atc gat gcg ctg cac aac gct cgc ggg acc cac 307His Gln Gly Glu Leu Ile Asp Ala Leu His Asn Ala Arg Gly Thr His

556065 atc ggt tgc gtg att aac ccc ggc ggc ctg act aca ctt cgg tgg cgc 355Ile Gly Cys Val Ile Asn Pro Gly Gly Leu Thr Thr Leu Arg Trp Arg 70758085 ttt tgg atg ctg tgaaggcgtc tgagcttcct acc 390Phe Trp Met Leu<210>504<211>89<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>504Met Pro Gly Lys Ile Leu Leu Leu Asn Gly Pro Asn Leu Asn Met Leu 151015 Gly Lys Arg Glu Pro Asp Ile Tyr Gly His Asp Thr Leu Glu Asp Val

20 25 30Val Ala Leu Ala Thr Ala Glu Ala Ala Lys His Gly Leu Glu Val Glu

35 40 45Ala Leu Gln Ser Asn His Gln Gly Glu Leu Ile Asp Ala Leu His Asn

50 55 60Ala Arg Gly Thr His Ile Gly Cys Val Ile Asn Pro Gly Gly Leu Thr 65 70 75 80Thr Leu Arg Trp Arg Phe Trp Met Leu

85<210>505<211>621<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (598)<223>RXS03074<400>505tttgtgggca atctggtttt ttcgtaattg tgtgggatga atctcttaaa aattcacatt 60tagcaggaca agcatactgt tttagttcta tgctgtgggc atg act caa agt gct 115

Met Thr Gln Ser Ala

1 5cca gaa ttc att gcc acc gca gac ctc gta gac atc atc ggc gac aac 163Pro Glu Phe Ile Ala Thr Ala Asp Leu Val Asp Ile Ile Gly Asp Asn

10 15 20gcg caa tca tgc gac act cag ttt caa aac ctt gga ggt gcc aca gaa 211Ala Gln Ser Cys Asp Thr Gln Phe Gln Asn Leu Gly Gly Ala Thr Glu

25 30 35ttc cac gga ata ata acc acc gtg aaa tgc ttc caa gac aac gcc ctc 259Phe His Gly Ile Ile Thr Thr Val Lys Cys Phe Gln Asp Asn Ala Leu

40 45 50ctg aaa tcc atc ctg agc gag gat aat cct ggg gga gtg ctg gtt atc 307Leu Lys Ser Ile Leu Ser Glu Asp Asn Pro Gly Gly Val Leu Val Ile

55 60 65gat ggc gac gca tcc gtg cac acc gcg cta gtt ggc gac atc att gca 355Asp Gly Asp Ala Ser Val His Thr Ala Leu Val Gly Asp Ile Ile Ala 70 75 80 85gga ctt gga aaa gat cat ggt tgg tcc gga gta att gtc aac gga gca 403Gly Leu Gly Lys Asp His Gly Trp Ser Gly Val Ile Val Asn Gly Ala

90 95 100att cga gac tcc gca gtc atc ggc acc atg acc ttt ggt tgt aaa gcc 451Ile Arg Asp Ser Ala Val Ile Gly Thr Met Thr Phe Gly Cys Lys Ala

105 110 115ctt gga acc aac ccg cgg aaa tcc act aaa act ggt tcc ggc gaa cga 499Leu Gly Thr Asn Pro Arg Lys Ser Thr Lys Thr Gly Ser Gly Glu Arg

120 125 130gac gta gtg gta tcg att ggt ggc att gac ttc att cct ggt cat tac 547Asp Val Val Val Ser Ile Gly Gly Ile Asp Phe Ile Pro Gly His Tyr

135140145 gtc tac gcg gac tct gac gga att atc gtc acc gag gcg cca att aag 595Val Tyr Ala Asp Ser Asp Gly Ile Ile Val Thr Glu Ala Pro Ile Lys 150155160165 cag taatttgttt tgacgacgca gta 621Gln<210>506<211>166<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>506Met Thr Gln Ser Ala Pro Glu Phe Ile Ala Thr Ala Asp Leu Val Asp 151015 Ile Ile Gly Asp Asn Ala Gln Ser Cys Asp Thr Gln Phe Gln Asn Leu

20 25 30Gly Gly Ala Thr Glu Phe His Gly Ile Ile Thr Thr Val Lys Cys Phe

35 40 45Gln Asp Asn Ala Leu Leu Lys Ser Ile Leu Ser Glu Asp Asn Pro Gly

50 55 60Gly Val Leu Val Ile Asp Gly Asp Ala Ser Val His Thr Ala Leu Val 65 70 75 80Gly Asp Ile Ile Ala Gly Leu Gly Lys Asp His Gly Trp Ser Gly Val

85 90 95Ile Val Asn Gly Ala Ile Arg Asp Ser Ala Val Ile Gly Thr Met Thr

100 105 110Phe Gly Cys Lys Ala Leu Gly Thr Asn Pro Arg Lys Ser Thr Lys Thr

115 120 125Gly Ser Gly Glu Arg Asp Val Val Val Ser Ile Gly Gly Ile Asp Phe

130 135 140Ile Pro Gly His Tyr Val Tyr Ala Asp Ser Asp Gly Ile Ile Val Thr145 150 155 160Glu Ala Pro Ile Lys Gln

165<210>507<211>3075<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). - (3052)<223>RXC01434<400>507ggtttcctgc gcaccgtgat gattggtgcg gcgctgtcgc cggccatcgc ttcggcgttc 60aacactgcca acacgctgcc caacctgatc actggaaatc gtg ttg ggt gcg gtg 115

Val Leu Gly Ala Val

1 5ctg aca tcg ctg gtt att ccg gtc ctt acc cgc gcg gaa aaa gaa gac 163Leu Thr Ser Leu Val Ile Pro Val Leu Thr Arg Ala Glu Lys Glu Asp

10 15 20gcc gac ggc ggt tcc ggg ttc ttc agg cgg ctg ctc acc ctg tcg gtg 211Ala Asp Gly Gly Ser Gly Phe Phe Arg Arg Leu Leu Thr Leu Ser Val

25 30 35acg ctg ctg ggt ggt gtc acc atc ctg tcg att atc ggc gcg ccg ctg 259Thr Leu Leu Gly Gly Val Thr Ile Leu Ser Ile Ile Gly Ala Pro Leu

40 45 50ctg aca cgg atg atg ctg tcc tct gag gga caa gtc aac gtg gtc atg 307Leu Thr Arg Met Met Leu Ser Ser Glu Gly Gln Val Asn Val Val Met

55 60 65tcc acg gcc ttt gcg tat tgg ctg ctg cca cag att ttc ttc tac ggc 355Ser Thr Ala Phe Ala Tyr Trp Leu Leu Pro Gln Ile Phe Phe Tyr Gly 70 75 80 85ctg ttt gcc ctg ttc atg gct gtg ttg aac acc cgt gaa gtg ttc aaa 403Leu Phe Ala Leu Phe Met Ala Val Leu Asn Thr Arg Glu Val Phe Lys

90 95 100ccc ggc gcg tgg gca cct gtt gtc aac aat gtg atc acc ttg acc gtg 451Pro Gly Ala Trp Ala Pro Val Val Asn Asn Val Ile Thr Leu Thr Val

105 110 115ctg ggc gtg tac atg gtg ctg cct gcg cgt ttg cac ccg cat gag cag 499Leu Gly Val Tyr Met Val Leu Pro Ala Arg Leu His Pro His Glu Gln

120 125 130gtg ggc att ttt gat ccg cag atc att ttc ctc ggc gtg ggc acc acc 547Val Gly Ile Phe Asp Pro Gln Ile Ile Phe Leu Gly Val Gly Thr Thr

135 140 145ctt ggt gtg gtt gca cag tgt cta atc atg att ccg tac ctg cgt cgc 595Leu Gly Val Val Ala Gln Cys Leu Ile Met Ile Pro Tyr Leu Arg Arg150 155 160 165gcg ggc att gat atg cgc cct ctg tgg ggt atc gat gcg cgt ttg aag 643Ala Gly Ile Asp Met Arg Pro Leu Trp Gly Ile Asp Ala Arg Leu Lys

170 175 180caa ttc ggt ggc atg gcg atg gcg atc atc gtg tac gtg gca atc tcc 691Gln Phe Gly Gly Met Ala Met Ala Ile Ile Val Tyr Val Ala Ile Ser

185 190 195cag ttc ggt tac atc atc acc act cgc att gcg tcg att gca gac gat 739Gln Phe Gly Tyr Ile Ile Thr Thr Arg Ile Ala Ser Ile Ala Asp Asp

200 205 210gct gcg ccg ttt att tat cag cag cac tgg atg ttg ctg caa gtt cct 787Ala Ala Pro Phe Ile Tyr Gln Gln His Trp Met Leu Leu Gln Val Pro

215 220 225tat ggc atc atc ggc gtc acc ttg ctc acc gcg att atg ccg cga ctg 835Tyr Gly Ile Ile Gly Val Thr Leu Leu Thr Ala Ile Met Pro Arg Leu230 235 240 245tcc cgc aac gcg gca gac ggc gat gat agg gca gta gtc tct gac ctt 883Ser Arg Asn Ala Ala Asp Gly Asp Asp Arg Ala Val Val Ser Asp Leu

250 255 260cag ttg ggt tcc aag cta acc ttc atc gca ctg atc ccc atc gtg gtg 931Gln Leu Gly Ser Lys Leu Thr Phe Ile Ala Leu Ile Pro Ile Val Val

265 270 275ttc ttc acc gcc ttc ggt gtc cct att gcc aat ggc ctt ttt gcc tac 979Phe Phe Thr Ala Phe Gly Val Pro Ile Ala Asn Gly Leu Phe Ala Tyr

280 285 290ggc caa ttc gat gcc aac gcc gcc aac atc ctt ggt tgg act ctg agc 1027Gly Gln Phe Asp Ala Asn Ala Ala Asn Ile Leu Gly Trp Thr Leu Ser

295300 305ttc tct gct ttc acg ctg att cct tac gct ttg gtg ctg cta cat ctg 1075Phe Ser Ala Phe Thr Leu Ile Pro Tyr Ala Leu Val Leu Leu His Leu310 315 320 325cgt gtg ttt tat gcg cgt gaa gag gtc tgg acc cca acc ttc atc atc 1123Arg Val Phe Tyr Ala Arg Glu Glu Val Trp Thr Pro Thr Phe Ile Ile

330 335 340gcc ggc atc acc gcc acc aag gtc gtg ctt tcc ctg ttg gca ccg ctg 1171Ala Gly Ile Thr Ala Thr Lys Val Val Leu Ser Leu Leu Ala Pro Leu

345 350 355ctg tcg agc tcc ccg gag cgt gtg gtg gtg ctt ctt ggt gcg gcc aac 1219Leu Ser Ser Ser Pro Glu Arg Val Val Val Leu Leu Gly Ala Ala Asn

360 365 370ggt ttc agt ttc atc acc ggc gcg gtc atc ggc gcg tat ctg ttg cgc 1267Gly Phe Ser Phe Ile Thr Gly Ala Val Ile Gly Ala Tyr Leu Leu Arg

375 380 385aac aaa ctc ggc ctg ttg ggt atg cgc tct ttg gct aaa acc tcc ctg 1315Asn Lys Leu Gly Leu Leu Gly Met Arg Ser Leu Ala Lys Thr Ser Leu390 395 400 405tgg gcg ttg ggc tct gcg gcg gtt ggt gca gca gca gca tgg gcg ttg 1363Trp Ala Leu Gly Ser Ala Ala Val Gly Ala Ala Ala Ala Trp Ala Leu

410 415 420ggg tgg ctg att caa gcc gtc gtg ggc gat ttc ttg ctg ggc act cta 1411Gly Trp Leu Ile Gln Ala Val Val Gly Asp Phe Leu Leu Gly Thr Leu

425 430 435agc tcc gta ggc tac ttg ttg aac ctg gct gtg ttg ggt gtc ttc ttc 1459Ser Ser Val Gly Tyr Leu Leu Asn Leu Ala Val Leu Gly Val Phe Phe

440 445 450atc ttc gtc acc ggc atc gtg ttg tca cgt tct ggt ttg ccg gag gtc 1507Ile Phe Val Thr Gly Ile Val Leu Ser Arg Ser Gly Leu Pro Glu Val

455 460 465caa aac ttg ggc cag gca ctg acc cgc atc cca ggt ttg agc cgg ttt 1555Gln Asn Leu Gly Gln Ala Leu Thr Arg Ile Pro Gly Leu Ser Arg Phe470 475 480 485att cgc ccg aat acc aag atc tct ttg gat gtc ggc gaa gtc tcc gag 1603Ile Arg Pro Asn Thr Lys Ile Ser Leu Asp Val Gly Glu Val Ser Glu

490 495 500cag gat ttc tcc acc cag ctg gtc gcg cca agc gag ttc gca gca acc 1651Gln Asp Phe Ser Thr Gln Leu Val Ala Pro Ser Glu Phe Ala Ala Thr

505 510 515cct gtg ccg cca ccg atg tcc gcc ggt att gtc cgc gga cct cgc ctg 1699Pro Val Pro Pro Pro Met Ser Ala Gly Ile Val Arg Gly Pro Arg Leu

520 525 530gtt ccc ggc gcc cca gtc ggc gac ggt cgt ttc cgt ctg ctc gcc gat 1747Val Pro Gly Ala Pro Val Gly Asp Gly Arg Phe Arg Leu Leu Ala Asp

535 540 545cac ggc ggc gtc caa ggc gcg cgt ttc tgg cag gcc cgc gag atc gcc 1795His Gly Gly Val Gln Gly Ala Arg Phe Trp Gln Ala Arg Glu Ile Ala550 555 560 565acc ggc aag gaa gtc gcg ctg atc ttt gtg gat act tcc ggc aac gcc 1843Thr Gly Lys Glu Val Ala Leu Ile Phe Val Asp Thr Ser Gly Asn Ala

570 575 580cca ttt gcg cca ctg tct tcg gca gcc gca gcg ggc atc gcc tac gag 1891Pro Phe Ala Pro Leu Ser Ser Ala Ala Ala Ala Gly Ile Ala Tyr Glu

585 590 595gtg cag cgc cgc acc aag aag ctg gcc agc ttg ggc agc ttg gcg gta 1939Val Gln Arg Arg Thr Lys Lys Leu Ala Ser Leu Gly Ser Leu Ala Val

600 605 610gcc ccc aac atc cac tcc gag gcg tac cgc aac ggt tgc ctc att gtg 1987Ala Pro Asn Ile His Ser Glu Ala Tyr Arg Asn Gly Cys Leu Ile Val

615 620 625gcc gat tgg gtg cct ggc tcc agc ttg agc gcc gtc gcg gaa tcc ggt 2035Ala Asp Trp Val Pro Gly Ser Ser Leu Ser Ala Val Ala Glu Ser Gly630 635 640 645gcc gat ccc cgc gcc gcc gcg ttc gcg ctc gcg gaa cta act gaa acc 2083Ala Asp Pro Arg Ala Ala Ala Phe Ala Leu Ala Glu Leu Thr Glu Thr

650 655 660atc ggc gag gcc cac gag atg ggt atc ccg gcc ggc ttg gac aac aag 2131Ile Gly Glu Ala His Glu Met Gly Ile Pro Ala Gly Leu Asp Asn Lys

665 670 675tgc cga att cgt atc aac acc gac ggc cat gcc gtc ctc gcc ttg ccg 2179Cys Arg Ile Arg Ile Asn Thr Asp Gly His Ala Val Leu Ala Leu Pro

680 685 690gcg att ttg ccc gat gcc tca gag ctc cgc gac gcc aag tcc ctg gcc 2227Ala Ile Leu Pro Asp Ala Ser Glu Leu Arg Asp Ala Lys Ser Leu Ala

695 700 705tcg gcc gcc gag atg ctt atc gac gcg acc ctc gct ccc agc gac gtc 2275Ser Ala Ala Glu Met Leu Ile Asp Ala Thr Leu Ala Pro Ser Asp Val710 715 720 725aag gca atg gtc act gaa gcc cag ggg cta gct aca gaa gac aat ccc 2323Lys Ala Met Val Thr Glu Ala Gln Gly Leu Ala Thr Glu Asp Asn Pro

730 735 740gat tac gca tca ctt gcc atg gcg atg cgc acc tgc gga ctg ttc acc 2371Asp Tyr Ala Ser Leu Ala Met Ala Met Arg Thr Cys Gly Leu Phe Thr

745 750 755gag gaacca acc cac ctt gtg gtg aag aag gaa aag aca cca aag cct 2419Glu Glu Pro Thr His Leu Val Val Lys Lys Glu Lys Thr Pro Lys Pro

760 765 770gcg aca cgt gat ggt ttc ggt gcc tcc gac tac acc gtc aag ggc atg 2467Ala Thr Arg Asp Gly Phe Gly Ala Ser Asp Tyr Thr Val Lys Gly Met

775 780 785gca gcc atc gcc gct gtg gtg atc atc ttg gtt tcc ctg gtg gcc gcc 2515Ala Ala Ile Ala Ala Val Val Ile Ile Leu Val Ser Leu Val Ala Ala790 795 800 805ggt acc gcg ttc ctc acc agc ttc ttc ggc agc agc acc aac gaa caa 2563Gly Thr Ala Phe Leu Thr Ser Phe Phe Gly Ser Ser Thr Asn Glu Gln

810 815 820tcc ccg ttg gcc tct gtt gaa gcc acc acc tct gca aca cca gaa cct 2611Ser Pro Leu Ala Ser Val Glu Ala Thr Thr Ser Ala Thr Pro Glu Pro

825 830 835gtg ggg cca ccg gtc tac ctg gat ctg gat caa gcc cgc acg tgg gat 2659Val Gly Pro Pro Val Tyr Leu Asp Leu Asp Gln Ala Arg Thr Trp Asp

840 845 850gac ggt gca gga aca gat gtc acc gac gtc acc gac ggc aac acc tcc 2707Asp Gly Ala Gly Thr Asp Val Thr Asp Val Thr Asp Gly Asn Thr Ser

855 860 865acc gca tgg acc tcc acc ggc ggc gac ggc ctc cta gtt gac ctg tcc 2755Thr Ala Trp Thr Ser Thr Gly Gly Asp Gly Leu Leu Val Asp Leu Ser870 875 880 885acg cct gcc cgc ctc gac cgc gtc atc ttg acc acc ggc acc ggc tcc 2803Thr Pro Ala Arg Leu Asp Arg Val Ile Leu Thr Thr Gly Thr Gly Ser

890 895 900gac agc aac gtg acc tcg acc gtg aag atc tac gca ttc aac gac gcc 2851Asp Ser Asn Val Thr Ser Thr Val Lys Ile Tyr Ala Phe Asn Asp Ala

905 910 915tca cca cac tcc ctg tcg gaa ggc atc gag atc ggc acc gtg gat tat 2899Ser Pro His Ser Leu Ser Glu Gly Ile Glu Ile Gly Thr Val Asp Tyr

920 925 930tcc ggc cgc agt ctc agc cac agc atc cgc gat tcc tcc aag ctt ccg 2947Ser Gly Arg Ser Leu Ser His Ser Ile Arg Asp Ser Ser Lys Leu Pro

935 940 945ggt cag gtg gaa tcc gtg gtg att ctg gtc gat gag gtt cgt tcc tca 2995Gly Gln Val Glu Ser Val Val Ile Leu Val Asp Glu Val Arg Ser Ser950 955 960 965caa acc tca gac acc aat cca cag atg cag atc gct gaa gta caa ctt 3043Gln Thr Ser Asp Thr Asn Pro Gln Met Gln Ile Ala Glu Val Gln Leu

970975980 gtt ggt tgg taaattacgc gtttgtgatt gac 3075Val Gly Trp<210>508<211>984<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>508Val Leu Gly Ala Val Leu Thr Ser Leu Val Ile Pro Val Leu Thr Arg 151015 Ala Glu Lys Glu Asp Ala Asp Gly Gly Ser Gly Phe Phe Arg Arg Leu

20 25 30Leu Thr Leu Ser Val Thr Leu Leu Gly Gly Val Thr Ile Leu Ser Ile

35 40 45Ile Gly Ala Pro Leu Leu Thr Arg Met Met Leu Ser Ser Glu Gly Gln

50 55 60Val Asn Val Val Met Ser Thr Ala Phe Ala Tyr Trp Leu Leu Pro Gln65 70 75 80Ile Phe Phe Tyr Gly Leu Phe Ala Leu Phe Met Ala Val Leu Asn Thr

85 90 95Arg Glu Val Phe Lys Pro Gly Ala Trp Ala Pro Val Val Asn Asn Val

100105 110Ile Thr Leu Thr Val Leu Gly Val Tyr Met Val Leu Pro Ala Arg Leu

115 120 125His Pro His Glu Gln Val Gly Ile Phe Asp Pro Gln Ile Ile Phe Leu

130 135 140Gly Val Gly Thr Thr Leu Gly Val Val Ala Gln Cys Leu Ile Met Ile145 150 155 160Pro Tyr Leu Arg Arg Ala Gly Ile Asp Met Arg Pro Leu Trp Gly Ile

165 170 175Asp Ala Arg Leu Lys Gln Phe Gly Gly Met Ala Met Ala Ile Ile Val

180 185 190Tyr Val Ala Ile Ser Gln Phe Gly Tyr Ile Ile Thr Thr Arg Ile Ala

195 200 205Ser Ile Ala Asp Asp Ala Ala Pro Phe Ile Tyr Gln Gln His Trp Met

210 215 220Leu Leu Gln Val Pro Tyr Gly Ile Ile Gly Val Thr Leu Leu Thr Ala225 230 235 240Ile Met Pro Arg Leu Ser Arg Asn Ala Ala Asp Gly Asp Asp Arg Ala

245 250 255Val Val Ser Asp Leu Gln Leu Gly Ser Lys Leu Thr Phe Ile Ala Leu

260 265 270Ile Pro Ile Val Val Phe Phe Thr Ala Phe Gly Val Pro Ile Ala Asn

275 280 285Gly Leu Phe Ala Tyr Gly Gln Phe Asp Ala Asn Ala Ala Asn Ile Leu

290 295 300Gly Trp Thr Leu Ser Phe Ser Ala Phe Thr Leu Ile Pro Tyr Ala Leu305 310 315 320Val Leu Leu His Leu Arg Val Phe Tyr Ala Arg Glu Glu Val Trp Thr

325 330 335Pro Thr Phe Ile Ile Ala Gly Ile Thr Ala Thr Lys Val Val Leu Ser

340 345 350Leu Leu Ala Pro Leu Leu Ser Ser Ser Pro Glu Arg Val Val Val Leu

355 360 365Leu Gly Ala Ala Asn Gly Phe Ser Phe Ile Thr Gly Ala Val Ile Gly

370 375 380Ala Tyr Leu Leu Arg Asn Lys Leu Gly Leu Leu Gly Met Arg Ser Leu385 390 395 400Ala Lys Thr Ser Leu Trp Ala Leu Gly Ser Ala Ala Val Gly Ala Ala

405 410 415Ala Ala Trp Ala Leu Gly Trp Leu Ile Gln Ala Val Val Gly Asp Phe

420 425 430Leu Leu Gly Thr Leu Ser Ser Val Gly Tyr Leu Leu Asn Leu Ala Val

435 440 445Leu Gly Val Phe Phe Ile Phe Val Thr Gly Ile Val Leu Ser Arg Ser

450 455 460Gly Leu Pro Glu Val Gln Asn Leu Gly Gln Ala Leu Thr Arg Ile Pro465 470 475 480Gly Leu Ser Arg Phe Ile Arg Pro Asn Thr Lys Ile Ser Leu Asp Val

485 490 495Gly Glu Val Ser Glu Gln Asp Phe Ser Thr Gln Leu Val Ala Pro Ser

500 505 510Glu Phe Ala Ala Thr Pro Val Pro Pro Pro Met Ser Ala Gly Ile Val

515 520 525Arg Gly Pro Arg Leu Val Pro Gly Ala Pro Val Gly Asp Gly Arg Phe

530 535 540Arg Leu Leu Ala Asp His Gly Gly Val Gln Gly Ala Arg Phe Trp Gln545550 555 560Ala Arg Glu Ile Ala Thr Gly Lys Glu Val Ala Leu Ile Phe Val Asp

565 570 575Thr Ser Gly Asn Ala Pro Phe Ala Pro Leu Ser Ser Ala Ala Ala Ala

580 585 590Gly Ile Ala Tyr Glu Val Gln Arg Arg Thr Lys Lys Leu Ala Ser Leu

595 600 605Gly Ser Leu Ala Val Ala Pro Asn Ile His Ser Glu Ala Tyr Arg Asn

610 615 620Gly Cys Leu Ile Val Ala Asp Trp Val Pro Gly Ser Ser Leu Ser Ala625 630 635 640Val Ala Glu Ser Gly Ala Asp Pro Arg Ala Ala Ala Phe Ala Leu Ala

645 650 655Glu Leu Thr Glu Thr Ile Gly Glu Ala His Glu Met Gly Ile Pro Ala

660 665 670Gly Leu Asp Asn Lys Cys Arg Ile Arg Ile Asn Thr Asp Gly His Ala

675 680 685Val Leu Ala Leu Pro Ala Ile Leu Pro Asp Ala Ser Glu Leu Arg Asp

690 695 700Ala Lys Ser Leu Ala Ser Ala Ala Glu Met Leu Ile Asp Ala Thr Leu705 710 715 720Ala Pro Ser Asp Val Lys Ala Met Val Thr Glu Ala Gln Gly Leu Ala

725 730 735Thr Glu Asp Asn Pro Asp Tyr Ala Ser Leu Ala Met Ala Met Arg Thr

740 745 750Cys Gly Leu Phe Thr Glu Glu Pro Thr His Leu Val Val Lys Lys Glu

755 760 765Lys Thr Pro Lys Pro Ala Thr Arg Asp Gly Phe Gly Ala Ser Asp Tyr

770 775 780Thr Val Lys Gly Met Ala Ala Ile Ala Ala Val Val Ile Ile Leu Val785 790 795 800Ser Leu Val Ala Ala Gly Thr Ala Phe Leu Thr Ser Phe Phe Gly Ser

805 810 815Ser Thr Asn Glu Gln Ser Pro Leu Ala Ser Val Glu Ala Thr Thr Ser

820 825 830Ala Thr Pro Glu Pro Val Gly Pro Pro Val Tyr Leu Asp Leu Asp Gln

835 840 845Ala Arg Thr Trp Asp Asp Gly Ala Gly Thr Asp Val Thr Asp Val Thr

850 855 860Asp Gly Asn Thr Ser Thr Ala Trp Thr Ser Thr Gly Gly Asp Gly Leu865 870 875 880Leu Val Asp Leu Ser Thr Pro Ala Arg Leu Asp Arg Val Ile Leu Thr

885 890 895Thr Gly Thr Gly Ser Asp Ser Asn Val Thr Ser Thr Val Lys Ile Tyr

900 905 910Ala Phe Asn Asp Ala Ser Pro His Ser Leu Ser Glu Gly Ile Glu Ile

915 920 925Gly Thr Val Asp Tyr Ser Gly Arg Ser Leu Ser His Ser Ile Arg Asp

930 935 940Ser Ser Lys Leu Pro Gly Gln Val Glu Ser Val Val Ile Leu Val Asp945 950 955 960Glu Val Arg Ser Ser Gln Thr Ser Asp Thr Asn Pro Gln Met Gln Ile

965 970 975Ala Glu Val Gln Leu Val Gly Trp

980<210>509<211>930<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) · (907)<223>RXC02080<400>509cgtaaattcg aagcgagctt ctaattctag caagcttggt gatggagtat cctgccaaaa 60tttgtcctgt tgcttattgt gcaggaattc ggaggcggac atg tca atc gag tgg 115

Met Ser Ile Glu Trp

1 5tta caa att gtt gaa tta gga gcg atc ttt ggt gca ggt ttc ctc gca 163Leu Gln Ile Val Glu Leu Gly Ala Ile Phe Gly Ala Gly Phe Leu Ala

10 15 20gga agc atc aat gta att gtc gga gca gga aca tta gtg tcg ttt cct 211Gly Ser Ile Asn Val Ile Val Gly Ala Gly Thr Leu Val Ser Phe Pro

25 30 35att ctc gtg ttc ctg ggc ctt cca ccg ttg act gcc acc atc gcc aac 259Ile Leu Val Phe Leu Gly Leu Pro Pro Leu Thr Ala Thr Ile Ala Asn

40 45 50acc atc ggc atc gtt cct gga agt att tcg ggt gtg gtt gct tat aga 307Thr Ile Gly Ile Val Pro Gly Ser Ile Ser Gly Val Val Ala Tyr Arg

55 60 65cgt gaa cta cac gcc cat gta aaa acc atc aga ttt ctg ctg cca gca 355Arg Glu Leu His Ala His Val Lys Thr Ile Arg Phe Leu Leu Pro Ala 70 75 80 85tca atc ctc gga ggg atc acc ggc gcc tcg ctc ttg ctg cat ttc tcc 403Ser Ile Leu Gly Gly Ile Thr Gly Ala Ser Leu Leu Leu His Phe Ser

90 95 100gca gat gtt ttt aca gca gta att ccc tgg ctg att gga ttc ggc acg 451Ala Asp Val Phe Thr Ala Val Ile Pro Trp Leu Ile Gly Phe Gly Thr

105 110 115ctg ttg gtt atc gca ggt cca tca att aag aag cat gtt ggc gct cat 499Leu Leu Val Ile Ala Gly Pro Ser Ile Lys Lys His Val Gly Ala His

120 125 130act tca ggt ggc atc tct gct ggg ttt agg caa ttg cct ttc ccg agc 547Thr Ser Gly Gly Ile Ser Ala Gly Phe Arg Gln Leu Pro Phe Pro Ser

135 140 145cga acc acc ttc atc gtc tca gta tgt ggt gcc ctg ttg ctg ggc atg 595Arg Thr Thr Phe Ile Val Ser Val Cys Gly Ala Leu Leu Leu Gly Met150 155 160 165tat gga ggg tac ttc agc gca gct caa ggc att ctt ctc atc gca ttg 643Tyr Gly Gly Tyr Phe Ser Ala Ala Gln Gly Ile Leu Leu Ile Ala Leu

170 175 180ctt ggc atc aca tca acg ctg cag atg cag gaa ctc aac gcc atc aaa 691Leu Gly Ile Thr Ser Thr Leu Gln Met Gln Glu Leu Asn Ala Ile Lys

185 190 195aac ctc aca gtg gcg gca gtt aat ctc atc gca gcc agt gtt ttt ata 739Asn Leu Thr Val Ala Ala Val Asn Leu Ile Ala Ala Ser Val Phe Ile

200 205 210atc atc tcc cct gag ttg atc tcc tgg ccg acc gtt gcc tta atc gcg 787Ile Ile Ser Pro Glu Leu Ile Ser Trp Pro Thr Val Ala Leu Ile Ala

215 220 225ctt ggc tca gct tta ggt gga tac atc ggc gga cgg tac gcc cgc cga 835Leu Gly Ser Ala Leu Gly Gly Tyr Ile Gly Gly Arg Tyr Ala Arg Arg230 235 240 245ctt cgc ccc agt gtt ttt aga gca ttt gtg gtc atc gtc gga atc acc 883Leu Arg Pro Ser Val Phe Arg Ala Phe Val Val Ile Val Gly Ile Thr

250 255 260acg gtc atc gtt atg acg atc ggt taatgcagca gactagtaac ccc 930Thr Val Ile Val Met Thr Ile Gly

265<210>510<211>269<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>510Met Ser Ile Glu Trp Leu Gln Ile Val Glu Leu Gly Ala Ile Phe Gly 151015 Ala Gly Phe Leu Ala Gly Ser Ile Asn Val Ile Val Gly Ala Gly Thr

20 25 30Leu Val Ser Phe Pro Ile Leu Val Phe Leu Gly Leu Pro Pro Leu Thr

35 40 45Ala Thr Ile Ala Asn Thr Ile Gly Ile Val Pro Gly Ser Ile Ser Gly

50 55 60Val Val Ala Tyr Arg Arg Glu Leu His Ala His Val Lys Thr Ile Arg 65 70 75 80Phe Leu Leu Pro Ala Ser Ile Leu Gly Gly Ile Thr Gly Ala Ser Leu

85 90 95Leu Leu His Phe Ser Ala Asp Val Phe Thr Ala Val Ile Pro Trp Leu

100 105 110Ile Gly Phe Gly Thr Leu Leu Val Ile Ala Gly Pro Ser Ile Lys Lys

115 120 125His Val Gly Ala His Thr Ser Gly Gly Ile Ser Ala Gly Phe Arg Gln

130 135 140Leu Pro Phe Pro Ser Arg Thr Thr Phe Ile Val Ser Val Cys Gly Ala145 150 155 160Leu Leu Leu Gly Met Tyr Gly Gly Tyr Phe Ser Ala Ala Gln Gly Ile

165 170 175Leu Leu Ile Ala Leu Leu Gly Ile Thr Ser Thr Leu Gln Met Gln Glu

180 185 190Leu Asn Ala Ile Lys Asn Leu Thr Val Ala Ala Val Asn Leu Ile Ala

195 200 205Ala Ser Val Phe Ile Ile Ile Ser Pro Glu Leu Ile Ser Trp Pro Thr

210 215220Val Ala Leu Ile Ala Leu Gly Ser Ala Leu Gly Gly Tyr Ile Gly Gly225 230 235 240Arg Tyr Ala Arg Arg Leu Arg Pro Ser Val Phe Arg Ala Phe Val Val

245 250 255Ile Val Gly Ile Thr Thr Val Ile Val Met Thr Ile Gly

260265<210>511<211>669<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<646>rxC02789<400>511ttcttccgta cggctatgct taaaagctaa atttgtcttt gtgccttgca acacattaat 60ttcttaacac taaacaatgg aaaggtaagc gggtttttct atg aag gtt tcc gcc 115

Met Lys Val Ser Ala

1 5gat aca ccc ggt cac gat gat cca ggc cca ggc cgg cgc ctt ggc tta 163Asp Thr Pro Gly His Asp Asp Pro Gly Pro Gly Arg Arg Leu Gly Leu

10 15 20gat gtc ggc acc gtg cgc atc gga gtg gca gcc tct gac cgc gat gcc 211Asp Val Gly Thr Val Arg Ile Gly Val Ala Ala Ser Asp Arg Asp Ala

25 30 35aag ctt gcc atg cct gtg gaa acc gtt ccg cgg gaa act gga ttc aaa 259Lys Leu Ala Met Pro Val Glu Thr Val Pro Arg Glu Thr Gly Phe Lys

40 45 50ggg cca gac ctg gcc gat att gat cgg ttg gtc gcc atc gtt gag gaa 307Gly Pro Asp Leu Ala Asp Ile Asp Arg Leu Val Ala Ile Val Glu Glu

55 60 65tac aac gcc gtg gaa gtc att gtt ggt cta ccc aca gat ctg cag gga 355Tyr Asn Ala Val Glu Val Ile Val Gly Leu Pro Thr Asp Leu Gln Gly 70 75 80 85aat ggc tcc gcc agt gtg aag cat gca aag gaa att gct ttc cgc gtc 403Asn Gly Ser Ala Ser Val Lys His Ala Lys Glu Ile Ala Phe Arg Val

90 95 100cgt cgg cgc ctc acc aat gct gga aag aac att ccg gta cgg ctt ggc 451Arg Arg Arg Leu Thr Asn Ala Gly Lys Asn Ile Pro Val Arg Leu Gly

105 110 115gac gaa cgc ctc acc acc gtc gtg gcc acc caa gcc ttg cgg gcc tca 499Asp Glu Arg Leu Thr Thr Val Val Ala Thr Gln Ala Leu Arg Ala Ser

120 125 130gga gtc agc gaa aaa gcg gga cgt aaa gtt att gat caa gct gcc gca 547Gly Val Ser Glu Lys Ala Gly Arg Lys Val Ile Asp Gln Ala Ala Ala

135 140 145gta gaa atc ctt caa acc tgg ttg gat gct cgc acc cga gcc ctt gaa 595Val Glu Ile Leu Gln Thr Trp Leu Asp Ala Arg Thr Arg Ala Leu Glu150 155 160 165cca caa tcc aca gac acc caa gat ttc gac gag aag gga aat ttc cca 643Pro Gln Ser Thr Asp Thr Gln Asp Phe Asp Glu Lys Gly Asn Phe Pro

170175180 gga tgaaccaaat ccgaaaccgc cgg 669Gly<210>512<211>182<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>512Met Lys Val Ser Ala Asp Thr Pro Gly His Asp Asp Pro Gly Pro Gly 151015 Arg Arg Leu Gly Leu Asp Val Gly Thr Val Arg Ile Gly Val Ala Ala

20 25 30Ser Asp Arg Asp Ala Lys Leu Ala Met Pro Val Glu Thr Val Pro Arg

35 40 45Glu Thr Gly Phe Lys Gly Pro Asp Leu Ala Asp Ile Asp Arg Leu Val

50 55 60Ala Ile Val Glu Glu Tyr Asn Ala Val Glu Val Ile Val Gly Leu Pro 65 70 75 80Thr Asp Leu Gln Gly Asn Gly Ser Ala Ser Val Lys His Ala Lys Glu

85 90 95Ile Ala Phe Arg Val Arg Arg Arg Leu Thr Asn Ala Gly Lys Asn Ile

100 105 110Pro Val Arg Leu Gly Asp Glu Arg Leu Thr Thr Val Val Ala Thr Gln

115 120 125Ala Leu Arg Ala Ser Gly Val Ser Glu Lys Ala Gly Arg Lys Val Ile

130 135 140Asp Gln Ala Ala Ala Val Glu Ile Leu Gln Thr Trp Leu Asp Ala Arg145 150 155 160Thr Arg Ala Leu Glu Pro Gln Ser Thr Asp Thr Gln Asp Phe Asp Glu

165 170 175Lys Gly Asn Phe Pro Gly

180<210>513<211>903<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (880)<223>RXC02295<400>513ttcccatgct aatccgcgaa aatggcactt caacagccat atactttaaa caacacaaat 60gatgcaagac tgataccggg atgtgatagg agcgcaccac atg ggg ttg gaa tta 115

Met Gly Leu Glu Leu

1 5gca gct agc ggg tgg ggc atc ctc atc gca ggc gcc gcc gta gcc gga 163Ala Ala Ser Gly Trp Gly Ile Leu Ile Ala Gly Ala Ala Val Ala Gly

10 15 20tgg atc gac gca gta atc ggc ggt ggc gga ctc gtc ctc atc ccg ctg 211Trp Ile Asp Ala Val Ile Gly Gly Gly Gly Leu Val Leu Ile Pro Leu

25 30 35atc ctc gcg gtc atg ccg caa ctc gca cct gtg aca gcg ctg gcc tcc 259Ile Leu Ala Val Met Pro Gln Leu Ala Pro Val Thr Ala Leu Ala Ser

40 45 50aac aaa ctg gca gcc gtc acc ggc acg gca tcg gcg gca ttc acc ctg 307Asn Lys Leu Ala Ala Val Thr Gly Thr Ala Ser Ala Ala Phe Thr Leu

55 60 65gtc agg cgc gtc aaa ccc gac aaa aaa ctg ctt gcg ctc tac gtt ctg 355Val Arg Arg Val Lys Pro Asp Lys Lys Leu Leu Ala Leu Tyr Val Leu 70 75 80 85gtg gca gct gtg tgc tcc ggt gca ggc gcc ctg gct gcg agt ctc att 403Val Ala Ala Val Cys Ser Gly Ala Gly Ala Leu Ala Ala Ser Leu Ile

90 95 100gac aaa caa atc atg cga ccg ctg atc atc gtg ttg atg ctg gtc gtt 451Asp Lys Gln Ile Met Arg Pro Leu Ile Ile Val Leu Met Leu Val Val

105 110 115ggc ctg atc gtg gtg ttc aaa cca aac ttc gga acc ggc gaa agc aaa 499Gly Leu Ile Val Val Phe Lys Pro Asn Phe Gly Thr Gly Glu Ser Lys

120 125 130gcc ctg ccc acc gga tgg aaa cgc tgg gcc gcc atc gtt gca gtc gga 547Ala Leu Pro Thr Gly Trp Lys Arg Trp Ala Ala Ile Val Ala Val Gly

135 140 145ctc atc gca gcc tac gac ggc atc ttc gga ccc gga acc ggc atg ttc 595Leu Ile Ala Ala Tyr Asp Gly Ile Phe Gly Pro Gly Thr Gly Met Phe150 155 160 165ctc atc atg gcg ttc acc gca ctg ctc tcc caa aat ttc ctg tcc tcc 643Leu Ile Met Ala Phe Thr Ala Leu Leu Ser Gln Asn Phe Leu Ser Ser

170 175 180gca gcc atg gcg aag gtc gta aac acc gca aca aac ctg ggt gcg cta 691Ala Ala Met Ala Lys Val Val Asn Thr Ala Thr Asn Leu Gly Ala Leu

185 190195att gta ttc atc atc ggc ggc cac atg tgg tgg acc cta gga ctc gtg 739Ile Val Phe Ile Ile Gly Gly His Met Trp Trp Thr Leu Gly Leu Val

200 205 210ctg gca gtc gcc aat gtc gca ggc gca caa ctc ggt gcc cga acg gtg 787Leu Ala Val Ala Asn Val Ala Gly Ala Gln Leu Gly Ala Arg Thr Val

215 220 225ctt ggt ggc ggt acc agg cta att aga tac gca cta cta acc ctg gtt 835Leu Gly Gly Gly Thr Arg Leu Ile Arg Tyr Ala Leu Leu Thr Leu Val230 235 240 245gtc gtc atg agc gtc tac ctc acc tgg caa caa atc caa gga atg 880Val Val Met Ser Val Tyr Leu Thr Trp Gln Gln Ile Gln Gly Met

250255260 tagataagtc ggggcaaact cta 903<903>210<211>260<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>514Met Gly Leu Glu Leu Ala Ala Ser Gly Trp Gly Ile Leu Ile Ala Gly 151015 Ala Ala Val Ala Gly Trp Ile Asp Ala Val Ile Gly Gly Gly Gly Leu

20 25 30Val Leu Ile Pro Leu Ile Leu Ala Val Met Pro Gln Leu Ala Pro Val

35 40 45Thr Ala Leu Ala Ser Asn Lys Leu Ala Ala Val Thr Gly Thr Ala Ser

50 55 60Ala Ala Phe Thr Leu Val Arg Arg Val Lys Pro Asp Lys Lys Leu Leu 65 70 75 80Ala Leu Tyr Val Leu Val Ala Ala Val Cys Ser Gly Ala Gly Ala Leu

85 90 95Ala Ala Ser Leu Ile Asp Lys Gln Ile Met Arg Pro Leu Ile Ile Val

100 105 110Leu Met Leu Val Val Gly Leu Ile Val Val Phe Lys Pro Asn Phe Gly

115 120 125Thr Gly Glu Ser Lys Ala Leu Pro Thr Gly Trp Lys Arg Trp Ala Ala

130 135 140Ile Val Ala Val Gly Leu Ile Ala Ala Tyr Asp Gly Ile Phe Gly Pro145 150 155 160Gly Thr Gly Met Phe Leu Ile Met Ala Phe Thr Ala Leu Leu Ser Gln

165 170 175Asn Phe Leu Ser Ser Ala Ala Met Ala Lys Val Val Asn Thr Ala Thr

180 185 190Asn Leu Gly Ala Leu Ile Val Phe Ile Ile Gly Gly His Met Trp Trp

195 200 205Thr Leu Gly Leu Val Leu Ala Val Ala Asn Val Ala Gly Ala Gln Leu

210 215 220Gly Ala Arg Thr Val Leu Gly Gly Gly Thr Arg Leu Ile Arg Tyr Ala225 230 235 240Leu Leu Thr Leu Val Val Val Met Ser Val Tyr Leu Thr Trp Gln Gln

245 250 255Ile Gln Gly Met

260<210>515<211>1132<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1132)<223>RXN03063<400>515tgtctacaac ttcgccctca tggacatatt aacttcgttg cctcggagag aatactcatc 60acctagacaa cagtttgtat ctcacctcac aggaggaacc gtg gaa gat ctc tca 115

Val Glu Asp Leu Ser

1 5tac cgc atc ccg cag tcg cgc acc gtg gcc gag cag gtg cca ggg ccg 163Tyr Arg Ile Pro Gln Ser Arg Thr Val Ala Glu Gln Val Pro Gly Pro

10 15 20aag tcg aaagcg ctg gat gag cgt cga caa gca gca gta gca cga gca 211Lys Ser Lys Ala Leu Asp Glu Arg Arg Gln Ala Ala Val Ala Arg Ala

25 30 35ctt gca ccg ggt ctg cct gga tac gtg gtg gac gca gac ggt ggc atc 259Leu Ala Pro Gly Leu Pro Gly Tyr Val Val Asp Ala Asp Gly Gly Ile

40 45 50ttg gct gac gcg gac ggc aac cgt ttc atc gac ctg gcc tcc ggc atc 307Leu Ala Asp Ala Asp Gly Asn Arg Phe Ile Asp Leu Ala Ser Gly Ile

55 60 65gcc gtg acc acg gtc ggc gga tcc aac gcg gcc gtc gcg aaa gcc gtc 355Ala Val Thr Thr Val Gly Gly Ser Asn Ala Ala Val Ala Lys Ala Val 70 75 80 85ggc gcc gca gct gcc cgc ttc acc cac acc tgc ttc atg gtc tca cct 403Gly Ala Ala Ala Ala Arg Phe Thr His Thr Cys Phe Met Val Ser Pro

90 95 100tat gaa act tac gtg gcc atg gcg gag aga ctc aac gcc ttg act cca 451Tyr Glu Thr Tyr Val Ala Met Ala Glu Arg Leu Asn Ala Leu Thr Pro

105 110 115ggc gat cac gac aag aag agc gcg ctg ttt aac tct ggc gcc gaa gcc 499Gly Asp His Asp Lys Lys Ser Ala Leu Phe Asn Ser Gly Ala Glu Ala

120 125 130gtg gaa aac gcc gtc aag gtg gca cgc gcc tac acc ggc aag ggc gcg 547Val Glu Asn Ala Val Lys Val Ala Arg Ala Tyr Thr Gly Lys Gly Ala

135 140 145gtc gtg gtg ttc gac aac gcg tac cac gga cgg acc aac ctc acc atg 595Val Val Val Phe Asp Asn Ala Tyr His Gly Arg Thr Asn Leu Thr Met150 155 160 165gcg atg acc gcg aag aac cgc cca tac aag tcc gga ttc gga cca cta 643Ala Met Thr Ala Lys Asn Arg Pro Tyr Lys Ser Gly Phe Gly Pro Leu

170 175 180gcc gca gac gtc tac cgt gca cca atg tct tac cca ctg cgc gac gga 691Ala Ala Asp Val Tyr Arg Ala Pro Met Ser Tyr Pro Leu Arg Asp Gly

185 190 195ctg tcc ggc ccg gaa gcc gca gag cgc gcg atc tcc gtg atc gaa tcc 739Leu Ser Gly Pro Glu Ala Ala Glu Arg Ala Ile Ser Val Ile Glu Ser

200 205 210cag gtc gga gcc gaa aac ctc gcc tgc gtg gtc att gaa ccg atc cag 787Gln Val Gly Ala Glu Asn Leu Ala Cys Val Val Ile Glu Pro Ile Gln

215 220 225ggc gaa ggc gga ttc atc gtc ccc gca cca gga ttc ctc gca gcc att 835Gly Glu Gly Gly Phe Ile Val Pro Ala Pro Gly Phe Leu Ala Ala Ile230 235 240 245tcc acc tgg tgc cgc gag aac gac gtg gtg ttc atc gcc gat gaa atc 883Ser Thr Trp Cys Arg Glu Asn Asp Val Val Phe Ile Ala Asp Glu Ile

250 255 260caa tct ggc ttc ctg cgc acc ggc gac tgg ttc gcc agc gac gca gaa 931Gln Ser Gly Phe Leu Arg Thr Gly Asp Trp Phe Ala Ser Asp Ala Glu

265 270 275ggt gtg atc ccc gac gtc atc acc acc gca aaa ggc atc gcc ggc ggc 979Gly Val Ile Pro Asp Val Ile Thr Thr Ala Lys Gly Ile Ala Gly Gly

280 285 290atg cca cta tcc gca gtg acc ggc cgc gca gaa atc atg gac gca ccc 1027Met Pro Leu Ser Ala Val Thr Gly Arg Ala Glu Ile Met Asp Ala Pro

295 300 305ggc ccc ggc gcg ctc ggc gga acc tac ggc gga aac ccc gtt gct tgc 1075Gly Pro Gly Ala Leu Gly Gly Thr Tyr Gly Gly Asn Pro Val Ala Cys310 315 320325gcc gcg gca ctt gca gcc att gaa gtg atg gaa caa gcc gac ctt aag 1123Ala Ala Ala Leu Ala Ala Ile Glu Val Met Glu Gln Ala Asp Leu Lys

330335340 acc cgc gcg 1132Thr Arg Ala<210>516<211>344<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>516Val Glu Asp Leu Ser Tyr Arg Ile Pro Gln Ser Arg Thr Val Ala Glu 151015 Gln Val Pro Gly Pro Lys Ser Lys Ala Leu Asp Glu Arg Arg Gln Ala

20 25 30Ala Val Ala Arg Ala Leu Ala Pro Gly Leu Pro Gly Tyr Val Val Asp

35 40 45Ala Asp Gly Gly Ile Leu Ala Asp Ala Asp Gly Asn Arg Phe Ile Asp

50 55 60Leu Ala Ser Gly Ile Ala Val Thr Thr Val Gly Gly Ser Asn Ala Ala 65 70 75 80Val Ala Lys Ala Val Gly Ala Ala Ala Ala Arg Phe Thr His Thr Cys

85 90 95Phe Met Val Ser Pro Tyr Glu Thr Tyr Val Ala Met Ala Glu Arg Leu

100 105 110Asn Ala Leu Thr Pro Gly Asp His Asp Lys Lys Ser Ala Leu Phe Asn

115 120 125Ser Gly Ala Glu Ala Val Glu Asn Ala Val Lys Val Ala Arg Ala Tyr

130 135 140Thr Gly Lys Gly Ala Val Val Val Phe Asp Asn Ala Tyr His Gly Arg145 150 155 160Thr Asn Leu Thr Met Ala Met Thr Ala Lys Asn Arg Pro Tyr Lys Ser

165 170 175Gly Phe Gly Pro Leu Ala Ala Asp Val Tyr Arg Ala Pro Met Ser Tyr

180 185190Pro Leu Arg Asp Gly Leu Ser Gly Pro Glu Ala Ala Glu Arg Ala Ile

195 200 205Ser Val Ile Glu Ser Gln Val Gly Ala Glu Asn Leu Ala Cys Val Val

210 215 220Ile Glu Pro Ile Gln Gly Glu Gly Gly Phe Ile Val Pro Ala Pro Gly225 230 235 240Phe Leu Ala Ala Ile Ser Thr Trp Cys Arg Glu Asn Asp Val Val Phe

245 250 255Ile Ala Asp Glu Ile Gln Ser Gly Phe Leu Arg Thr Gly Asp Trp Phe

260 265 270Ala Ser Asp Ala Glu Gly Val Ile Pro Asp Val Ile Thr Thr Ala Lys

275 280 285Gly Ile Ala Gly Gly Met Pro Leu Ser Ala Val Thr Gly Arg Ala Glu

290 295 300Ile Met Asp Ala Pro Gly Pro Gly Ala Leu Gly Gly Thr Tyr Gly Gly305 310 315 320Asn Pro Val Ala Cys Ala Ala Ala Leu Ala Ala Ile Glu Val Met Glu

325 330 335Gln Ala Asp Leu Lys Thr Arg Ala

340<210>517<211>1491<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1468)<223>RXN02970<400>517aaccgacaaa acagccgttc acgtgctaaa gcagctcggc ttgatctagg gtgaggtgag 60ttatttaaag acttcataat attttgggga gtgaactggt ttg gca ttg aag ggt 115

Leu Ala Leu Lys Gly

1 5tac acc aac ttt gac ggt gaa ttc atc gaa ttc gga tct gtg caa gca 163Tyr Thr Asn Phe Asp Gly Glu Phe IleGlu Phe Gly Ser Val Gln Ala

10 15 20aaa gaa gag gaa aaa cgg gca ttc gac aac gat cgc gcg cac gtt ttc 211Lys Glu Glu Glu Lys Arg Ala Phe Asp Asn Asp Arg Ala His Val Phe

25 30 35cac tcc tgg tcc gcg cag gac aaa atc agc ccc aaa gta tgg gca gct 259His Ser Trp Ser Ala Gln Asp Lys Ile Ser Pro Lys Val Trp Ala Ala

40 45 50gcc gaa ggt tcc acg ctg tac gac ttc gac ggc aac gcc ttc atc gac 307Ala Glu Gly Ser Thr Leu Tyr Asp Phe Asp Gly Asn Ala Phe Ile Asp

55 60 65atg ggt tcc caa ctt gtc tcg gca aac tta ggc cac aac aac cct cga 355Met Gly Ser Gln Leu Val Ser Ala Asn Leu Gly His Asn Asn Pro Arg 70 75 80 85tta gtt gag gcg atc cag cgc caa gca gcc cgg ttg acc aac atc aac 403Leu Val Glu Ala Ile Gln Arg Gln Ala Ala Arg Leu Thr Asn Ile Asn

90 95 l00ccg gcc ttc ggc aat gat gtg cgc tct gat gtt gct gca aag atc gtg 451Pro Ala Phe Gly Asn Asp Val Arg Ser Asp Val Ala Ala Lys Ile Val

105 110 115tcg atg gcc cgt ggc gaa ttc tcc cac gtg ttt ttc acc aac ggc ggc 499Ser Met Ala Arg Gly Glu Phe Ser His Val Phe Phe Thr Asn Gly Gly

120 125 130gcc gac gcc atc gag cac tcc atc cgc atg gct cgc ctg cac acc gga 547Ala Asp Ala Ile Glu His Ser Ile Arg Met Ala Arg Leu His Thr Gly

135 140 145cgc aac aaa att ctg tcc gca tac cgc agc tac cac ggc gca acc gga 595Arg Asn Lys Ile Leu Ser Ala Tyr Arg Ser Tyr His Gly Ala Thr Gly150 155 160165tcc gcg atg atg ctc acc ggc gaa cac cgc cgc ctg ggc aac ccc acc 643Ser Ala Met Met Leu Thr Gly Glu His Arg Arg Leu Gly Asn Pro Thr

170 175 180acc gac cca gat atc tac cac ttc tgg gca cca ttc ctg cac cac tcc 691Thr Asp Pro Asp Ile Tyr His Phe Trp Ala Pro Phe Leu His His Ser

185 190 195tca ttc ttt gcc acc acc caa gaa gaa gaa tgc gaa cgc gca ctc aag 739Ser Phe Phe Ala Thr Thr Gln Glu Glu Glu Cys Glu Arg Ala Leu Lys

200 205 210cac ttg gaa gat gtc atc gcg ttt gaa ggt gct ggc atg atc gca gcg 787His Leu Glu Asp Val Ile Ala Phe Glu Gly Ala Gly Met Ile Ala Ala

215 220 225atc gtc ctg gag cca gtg gtg gga tca tca gga atc atc ctg cca cca 835Ile Val Leu Glu Pro Val Val Gly Ser Ser Gly Ile Ile Leu Pro Pro230 235 240 245gca ggt tac tta aat ggc gtg cgc gaa ctt tgc aac aag cac ggc atc 883Ala Gly Tyr Leu Asn Gly Val Arg Glu Leu Cys Asn Lys His Gly Ile

250 255 260ctc ttc atc gcc gac gaa gtc atg gtc gga ttc gga cgc acc gga aaa 931Leu Phe Ile Ala Asp Glu Val Met Val Gly Phe Gly Arg Thr Gly Lys

265 270 275ctg ttt gct tac gag cat gct ggc gac gat ttc cag cca gac atg atc 979Leu Phe Ala Tyr Glu His Ala Gly Asp Asp Phe Gln Pro Asp Met Ile

280 285 290acc ttc gcc aag ggt gtt aac gca ggt tac gcc cca ctc ggt ggc atc 1027Thr Phe Ala Lys Gly Val Asn Ala Gly Tyr Ala Pro Leu Gly Gly Ile

295 300 305gtg atg acc caa tca atc cgc gat acc ttc gga tca gag gca tac tcc 1075Val Met Thr Gln Ser Ile Arg Asp Thr Phe Gly Ser Glu Ala Tyr Ser310 315 320 325ggc gga ctc acc tac tcc gga cac cca ctt gca gta gca ccc gcc aag 1123Gly Gly Leu Thr Tyr Ser Gly His Pro Leu Ala Val Ala Pro Ala Lys

330 335 340gca gcg ctg gag att tac gcg gaa gga gag atc att cca cgc gta gct 1171Ala Ala Leu Glu Ile Tyr Ala Glu Gly Glu Ile Ile Pro Arg Val Ala

345 350 355cga ctt ggc gct gaa ctg atc gaa cct cgc ctt cgt gaa cta gcg gaa 1219Arg Leu Gly Ala Glu Leu Ile Glu Pro Arg Leu Arg Glu Leu Ala Glu

360 365 370gaa aac gta gcg atc gct gac gtg cgg ggc atc gga ttc ttc tgg gca 1267Glu Asn Val Ala Ile Ala Asp Val Arg Gly Ile Gly Phe Phe Trp Ala

375 380 385gtg gag ttc aat gca gac gcc act gcc atg gct gcc ggt gct gca gaa 1315Val Glu Phe Asn Ala Asp Ala Thr Ala Met Ala Ala Gly Ala Ala Glu390 395 400 405ttc aag gaa cgc ggc gtg tgg ccg atg atc tcc ggc aac cga ttc cac 1363Phe Lys Glu Arg Gly Val Trp Pro Met Ile Ser Gly Asn Arg Phe His

410 415 420atc gcg ccg ccg ctg acc acc act gat gac gaa ttg gta gca ctg ctg 1411Ile Ala Pro Pro Leu Thr Thr Thr Asp Asp Glu Leu Val Ala Leu Leu

425 430 435gac gcg gtg gaa gct gca gcc caa gct gtc gag ctg acc ttc gct ggg 1459Asp Ala Val Glu Ala Ala Ala Gln Ala Val Glu Leu Thr Phe Ala Gly

440 445 450gcg ttg ttc taagttttct agataacaag gcc 1491Ala Leu Phe

455<210>518<211>456<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>518Leu Ala Leu Lys Gly Tyr Thr Asn Phe Asp Gly Glu Phe Ile Glu Phe 151015 Gly Ser Val Gln Ala Lys Glu Glu Glu Lys Arg Ala Phe Asp Asn Asp

20 25 30Arg Ala His Val Phe His Ser Trp Ser Ala Gln Asp Lys Ile Ser Pro

35 40 45Lys Val Trp Ala Ala Ala Glu Gly Ser Thr Leu Tyr Asp Phe Asp Gly

50 55 60Asn Ala Phe Ile Asp Met Gly Ser Gln Leu Val Ser Ala Asn Leu Gly 65 70 75 80His Asn Asn Pro Arg Leu Val Glu Ala Ile Gln Arg Gln Ala Ala Arg

85 90 95Leu Thr Asn Ile Asn Pro Ala Phe Gly Asn Asp Val Arg Ser Asp Val

100 105 110Ala Ala Lys Ile Val Ser Met Ala Arg Gly Glu Phe Ser His Val Phe

115 120 125Phe Thr Asn Gly Gly Ala Asp Ala Ile Glu His Ser Ile Arg Met Ala

130 135 140Arg Leu His Thr Gly Arg Asn Lys Ile Leu Ser Ala Tyr Arg Ser Tyr145 150 155 160His Gly Ala Thr Gly Ser Ala Met Met Leu Thr Gly Glu His Arg Arg

165 170 175Leu Gly Asn Pro Thr Thr Asp Pro Asp Ile Tyr His Phe Trp Ala Pro

180 185 190Phe Leu His His Ser Ser Phe Phe Ala Thr Thr Gln Glu Glu Glu Cys

195 200 205Glu Arg Ala Leu Lys His Leu Glu Asp Val Ile Ala Phe Glu Gly Ala

210 215 220Gly Met Ile Ala Ala Ile Val Leu Glu Pro Val Val Gly Ser Ser Gly225 230 235 240Ile Ile Leu Pro Pro Ala Gly Tyr Leu Asn Gly Val Arg Glu Leu Cys

245 250 255Asn Lys His Gly Ile Leu Phe Ile Ala Asp Glu Val Met Val Gly Phe

260 265 270Gly Arg Thr Gly Lys Leu Phe Ala Tyr Glu His Ala Gly Asp Asp Phe

275 280 285Gln Pro Asp Met Ile Thr Phe Ala Lys Gly Val Asn Ala Gly Tyr Ala

290 295 300Pro Leu Gly Gly Ile Val Met Thr Gln Ser Ile Arg Asp Thr Phe Gly305 310 315 320Ser Glu Ala Tyr Ser Gly Gly Leu Thr Tyr Ser Gly His Pro Leu Ala

325 330 335Val Ala Pro Ala Lys Ala Ala Leu Glu Ile Tyr Ala Glu Gly Glu Ile

340 345 350Ile Pro Arg Val Ala Arg Leu Gly Ala Glu Leu Ile Glu Pro Arg Leu

355 360 365Arg Glu Leu Ala Glu Glu Asn Val Ala Ile Ala Asp Val Arg Gly Ile

370 375 380Gly Phe Phe Trp Ala Val Glu Phe Asn Ala Asp Ala Thr Ala Met Ala385 390 395 400Ala Gly Ala Ala Glu Phe Lys Glu Arg Gly Val Trp Pro Met Ile Ser

405 410 415Gly Asn Arg Phe His Ile Ala Pro Pro Leu Thr Thr Thr Asp Asp Glu

420 425 430Leu Val Ala Leu Leu Asp Ala Val Glu Ala Ala Ala Gln Ala Val Glu

435 440 445Leu Thr Phe Ala Gly Ala Leu Phe

450455<210>519<211>1330<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1330)<223>FRXA01009<400>519aaccgacaaa acagccgttc acgtgctaaa gcagctcggc ttgatctagg gtgaggtgag 60ttatttaaag acttcataat attttgggga gtgaactggt ttg gca ttg aag ggt 115

Leu Ala Leu Lys Gly

1 5tac acc aac ttt gac ggt gaa ttc atc gaa ttc gga tct gtg caa gca 163Tyr Thr Asn Phe Asp Gly Glu Phe Ile Glu Phe Gly Ser Val Gln Ala

10 15 20aaa gaa gag gaa aaa cgg gca ttc gac aac gat cgc gcg cac gtt ttc 211Lys Glu Glu Glu Lys Arg Ala Phe Asp Asn Asp Arg Ala His Val Phe

25 30 35cac tcc tgg tcc gcg cag gac aaa atc agc ccc aaa gta tgg gca gct 259His Ser Trp Ser Ala Gln Asp Lys Ile Ser Pro Lys Val Trp Ala Ala

40 45 50gcc gaa ggt tcc acg ctg tac gac ttc gac ggc aac gcc ttc atc gac 307Ala Glu Gly Ser Thr Leu Tyr Asp Phe Asp Gly Asn Ala Phe Ile Asp

55 60 65atg ggt tcc caa ctt gtc tcg gca aac tta ggc cac aac aac cct cga 355Met Gly Ser Gln Leu Val Ser Ala Asn Leu Gly His Asn Asn Pro Arg 70 75 80 85tta gtt gag gcg atc cag cgc caa gca gcc cgg ttg acc aac atc aac 403Leu Val Glu Ala Ile Gln Arg Gln Ala Ala Arg Leu Thr Asn Ile Asn

90 95 100ccg gcc ttc ggc aat gat gtg cgc tct gat gtt gctgca aag atc gtg 451Pro Ala Phe Gly Asn Asp Val Arg Ser Asp Val Ala Ala Lys Ile Val

105 110 115tcg atg gcc cgt ggc gaa ttc tcc cac gtg ttt ttc acc aac ggc ggc 499Ser Met Ala Arg Gly Glu Phe Ser His Val Phe Phe Thr Asn Gly Gly

120 125 130gcc gac gcc atc gag cac tcc atc cgc atg gct cgc ctg cac acc gga 547Ala Asp Ala Ile Glu His Ser Ile Arg Met Ala Arg Leu His Thr Gly

135 140 145cgc aac aaa att ctg tcc gca tac cgc agc tac cac ggc gca acc gga 595Arg Asn Lys Ile Leu Ser Ala Tyr Arg Ser Tyr His Gly Ala Thr Gly150 155 160 165tcc gcg atg atg ctc acc ggc gaa cac cgc cgc ctg ggc aac ccc acc 643Ser Ala Met Met Leu Thr Gly Glu His Arg Arg Leu Gly Asn Pro Thr

170 175 180acc gac cca gat atc tac cac ttc tgg gca cca ttc ctg cac cac tcc 691Thr Asp Pro Asp Ile Tyr His Phe Trp Ala Pro Phe Leu His His Ser

185 190 195tca ttc ttt gcc acc acc caa gaa gaa gaa tgc gaa cgc gca ctc aag 739Ser Phe Phe Ala Thr Thr Gln Glu Glu Glu Cys Glu Arg Ala Leu Lys

200 205 210cac ttg gaa gat gtc atc gcg ttt gaa ggt gct ggc atg atc gca gcg 787His Leu Glu Asp Val Ile Ala Phe Glu Gly Ala Gly Met Ile Ala Ala

215 220 225atc gtc ctg gag cca gtg gtg gga tca tca gga atc atc ctg cca cca 835Ile Val Leu Glu Pro Val Val Gly Ser Ser Gly Ile Ile Leu Pro Pro230 235 240 245gca ggt tac tta aat ggc gtg cgc gaa ctt tgc aac aag cac ggc atc 883Ala Gly Tyr Leu Asn Gly Val Arg Glu Leu Cys Asn Lys His Gly Ile

250 255 260ctc ttc atc gcc gac gaa gtc atg gtc gga ttc gga cgc acc gga aaa 931Leu Phe Ile Ala Asp Glu Val Met Val Gly Phe Gly Arg Thr Gly Lys

265 270 275ctg ttt gct tac gag cat gct ggc gac gat ttc cag cca gac atg atc 979Leu Phe Ala Tyr Glu His Ala Gly Asp Asp Phe Gln Pro Asp Met Ile

280 285 290acc ttc gcc aag ggt gtt aac gca ggt tac gcc cca ctc ggt ggc atc 1027Thr Phe Ala Lys Gly Val Asn Ala Gly Tyr Ala Pro Leu Gly Gly Ile

295 300 305gtg atg acc caa tca atc cgc gat acc ttc gga tca gag gca tac tcc 1075Val Met Thr Gln Ser Ile Arg Asp Thr Phe Gly Ser Glu Ala Tyr Ser310 315 320 325ggc gga ctc acc tac tcc gga cac cca ctt gca gta gca ccc gcc aag 1123Gly Gly Leu Thr Tyr Ser Gly His Pro Leu Ala Val Ala Pro Ala Lys

330 335 340gca gcg ctg gag att tac gcg gaa gga gag atc att cca cgc gta gct 1171Ala Ala Leu Glu Ile Tyr Ala Glu Gly Glu Ile Ile Pro Arg Val Ala

345 350 355cga ctt ggc gct gaa ctg atc gaa cct cgc ctt cgt gaa cta gcg gaa 1219Arg Leu Gly Ala Glu Leu Ile Glu Pro Arg Leu Arg Glu Leu Ala Glu

360 365 370gaa aac gta gcg atc gct gac gtg cgg ggc atc gga ttc ttc tgg gca 1267Glu Asn Val Ala Ile Ala Asp Val Arg Gly Ile Gly Phe Phe Trp Ala

375 380 385gtg gag ttc aat gca gac gcc act gcc atg gct gcc ggt gct gca gaa 1315Val Glu Phe Asn Ala Asp Ala Thr Ala Met Ala Ala Gly Ala Ala Glu390 395 400 405ttc aag gaa cgc ggc1330Phe Lys Glu Arg Gly

410<210>520<211>410<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>520Leu Ala Leu Lys Gly Tyr Thr Asn Phe Asp Gly Glu Phe Ile Glu Phe 151015 Gly Ser Val Gln Ala Lys Glu Glu Glu Lys Arg Ala Phe Asp Asn Asp

20 25 30Arg Ala His Val Phe His Ser Trp Ser Ala Gln Asp Lys Ile Ser Pro

35 40 45Lys Val Trp Ala Ala Ala Glu Gly Ser Thr Leu Tyr Asp Phe Asp Gly

50 55 60Asn Ala Phe Ile Asp Met Gly Ser Gln Leu Val Ser Ala Asn Leu Gly 65 70 75 80His Asn Asn Pro Arg Leu Val Glu Ala Ile Gln Arg Gln Ala Ala Arg

85 90 95Leu Thr Asn Ile Asn Pro Ala Phe Gly Asn Asp Val Arg Ser Asp Val

100 105 110Ala Ala Lys Ile Val Ser Met Ala Arg Gly Glu Phe Ser His Val Phe

115 120 125Phe Thr Asn Gly Gly Ala Asp Ala Ile Glu His Ser Ile Arg Met Ala

130 135 140Arg Leu His Thr Gly Arg Asn Lys Ile Leu Ser Ala Tyr Arg Ser Tyr145 150 155 160His Gly Ala Thr Gly Ser Ala Met Met Leu Thr Gly Glu His Arg Arg

165 170 175Leu Gly Asn Pro Thr Thr Asp Pro Asp Ile Tyr His Phe Trp Ala Pro

180 185 190Phe Leu His His Ser Ser Phe Phe Ala Thr Thr Gln Glu Glu Glu Cys

195200 205Glu Arg Ala Leu Lys His Leu Glu Asp Val Ile Ala Phe Glu Gly Ala

210 215 220Gly Met Ile Ala Ala Ile Val Leu Glu Pro Val Val Gly Ser Ser Gly225 230 235 240Ile Ile Leu Pro Pro Ala Gly Tyr Leu Asn Gly Val Arg Glu Leu Cys

245 250 255Asn Lys His Gly Ile Leu Phe Ile Ala Asp Glu Val Met Val Gly Phe

260 265 270Gly Arg Thr Gly Lys Leu Phe Ala Tyr Glu His Ala Gly Asp Asp Phe

275 280 285Gln Pro Asp Met Ile Thr Phe Ala Lys Gly Val Asn Ala Gly Tyr Ala

290 295 300Pro Leu Gly Gly Ile Val Met Thr Gln Ser Ile Arg Asp Thr Phe Gly305 310 315 320Ser Glu Ala Tyr Ser Gly Gly Leu Thr Tyr Ser Gly His Pro Leu Ala

325 330 335Val Ala Pro Ala Lys Ala Ala Leu Glu Ile Tyr Ala Glu Gly Glu Ile

340 345 350Ile Pro Arg Val Ala Arg Leu Gly Ala Glu Leu Ile Glu Pro Arg Leu

355 360 365Arg Glu Leu Ala Glu Glu Asn Val Ala Ile Ala Asp Val Arg Gly Ile

370 375 380Gly Phe Phe Trp Ala Val Glu Phe Asn Ala Asp Ala Thr Ala Met Ala385 390 395 400Ala Gly Ala Ala Glu Phe Lys Glu Arg Gly

405410<210>521<211>1998<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1975)<223>RXA01551<400>521cactacgtag gcgtacccca ccatcaccgc gtcgaaaagc gccctctctt aacccccgca 60agggggtaac ttttacgcgc acgcgtgcaa cgcgctagtt ttg aag gca gtc ccc 115

Leu Lys Ala Val Pro

1 5acg ggc gcc cga gca cgg gct gag atc gcg ctg att gct gcg cga gca 163Thr Gly Ala Arg Ala Arg Ala Glu Ile Ala Leu Ile Ala Ala Arg Ala

10 15 20ccg ttt gaa cct gtc cgg tta gca ccg gcg aag gaa gag agg aat ggt 211Pro Phe Glu Pro Val Arg Leu Ala Pro Ala Lys Glu Glu Arg Asn Gly

25 30 35gca atg acg cct acc caa aat gag atc cac ccg aaa cat agc tac tcc 259Ala Met Thr Pro Thr Gln Asn Glu Ile His Pro Lys His Ser Tyr Ser

40 45 50ccc atc cgc aag gac ggt ctc gag gtc ccg gag acc gaa atc cgc ctc 307Pro Ile Arg Lys Asp Gly Leu Glu Val Pro Glu Thr Glu Ile Arg Leu

55 60 65gat gac tcg cca agc ggc ccc aac gaa ccc ttc cgc atc tac cgc acc 355Asp Asp Ser Pro Ser Gly Pro Asn Glu Pro Phe Arg Ile Tyr Arg Thr 70 75 80 85cgt ggc cca gaa acc aac ccc aag cag gga ctt ccg cgg ctg cgc gag 403Arg Gly Pro Glu Thr Asn Pro Lys Gln Gly Leu Pro Arg Leu Arg Glu

90 95 100tca tgg atc acc gcc cgc ggc gac gtt gcc acc tat cag ggg cgc gag 451Ser Trp Ile Thr Ala Arg Gly Asp Val Ala Thr Tyr Gln Gly Arg Glu

105 110 115cgt ttg ctt atc gac gac ggc cgc tcg gca atg cgt cga ggt caa gct 499Arg Leu Leu Ile Asp Asp Gly Arg Ser Ala Met Arg Arg Gly Gln Ala

120 125 130tcg gct gag tgg aaa ggc caa aaa cca gct cct ttg aag gcg cta cct 547Ser Ala Glu Trp Lys Gly Gln Lys Pro Ala Pro Leu Lys Ala Leu Pro

135 140 145ggc aaa aga gtc acc caa atg gcc tat gca cgt gct ggc gtg att act 595Gly Lys Arg Val Thr Gln Met Ala Tyr Ala Arg Ala Gly Val Ile Thr150 155 160 165cgt gaa atg gag ttt gta gcg ctg cgc gaa cac gtt gat gcg gag ttt 643Arg Glu Met Glu Phe Val Ala Leu Arg Glu His Val Asp Ala Glu Phe

170 175 180gtg cgc tct gag gtg gcg cgc ggt cgg gcc att att ccc aac aac gtc 691Val Arg Ser Glu Val Ala Arg Gly Arg Ala Ile Ile Pro Asn Asn Val

185 190 195aac cac ccc gaa tct gaa ccg atg att att ggt cgc aaa ttt ttg acc 739Asn His Pro Glu Ser Glu Pro Met Ile Ile Gly Arg Lys Phe Leu Thr

200 205 210aaa atc aac gcc aat att ggc aat tct gcg gtc acc tct tca atc gag 787Lys Ile Asn Ala Asn Ile Gly Asn Ser Ala Val Thr Ser Ser Ile Glu

215 220 225gaa gag gtg tcc aag ctg cag tgg gcc acg cgc tgg ggt gcc gat acc 835Glu Glu Val Ser Lys Leu Gln Trp Ala Thr Arg Trp Gly Ala Asp Thr230 235 240 245gtg atg gat cta tcc acc ggc gat gat att cac acc acc cgc gaa tgg 883Val Met Asp Leu Ser Thr Gly Asp Asp Ile His Thr Thr Arg Glu Trp

250 255 260att atc cgc aac tcc ccc gtt cct atc ggc acc gtc ccg atc tac caa 931Ile Ile Arg Asn Ser Pro Val Pro Ile Gly Thr Val Pro Ile Tyr Gln

265 270 275gcg ctg gaa aaa gta aat ggc gtg gcc gca gac ctt aac tgg gaa gta979Ala Leu Glu Lys Val Asn Gly Val Ala Ala Asp Leu Asn Trp Glu Val

280 285 290ttc cgc gat acc atc att gag cag tgt gaa caa ggc gtg gac tat atg 1027Phe Arg Asp Thr Ile Ile Glu Gln Cys Glu Gln Gly Val Asp Tyr Met

295 300 305acc atc cac gcc ggc gtc ctg ctg gct tat atc cca ctg act acc cgt 1075Thr Ile His Ala Gly Val Leu Leu Ala Tyr Ile Pro Leu Thr Thr Arg310 315 320 325cgt gtc acc ggc att gtc tcc cgc ggc gga tcc att atg gcc ggt tgg 1123Arg Val Thr Gly Ile Val Ser Arg Gly Gly Ser Ile Met Ala Gly Trp

330 335 340tgt ctg gcg cat cac cgc gaa tca ttc ctc tac gag cat ttc gac gag 1171Cys Leu Ala His His Arg Glu Ser Phe Leu Tyr Glu His Phe Asp Glu

345 350 355ctg tgc gaa atc ttt gca caa tat gac gtc gca ttc tcc ctc ggt gat 1219Leu Cys Glu Ile Phe Ala Gln Tyr Asp Val Ala Phe Ser Leu Gly Asp

360 365 370ggc cta cgc ccc gga tcg ctt gcc gat gcc aac gac gcc gcg caa ttc 1267Gly Leu Arg Pro Gly Ser Leu Ala Asp Ala Asn Asp Ala Ala Gln Phe

375 380 385gcc gag ctg aaa acc att ggt gag ctc acc caa cgc gcc tgg gaa tac 1315Ala Glu Leu Lys Thr Ile Gly Glu Leu Thr Gln Arg Ala Trp Glu Tyr390 395 400 405gat gta caa gta atg gtc gaa gga cct gga cac gtg cca cta aac atg 1363Asp Val Gln Val Met Val Glu Gly Pro Gly His Val Pro Leu Asn Met

410 415 420atc cag gaa aac aac gag ctg gaa caa aag tgg gca gcg gac gca cct 1411Ile Gln Glu Asn Asn Glu Leu Glu Gln Lys Trp Ala Ala Asp Ala Pro

425 430 435ttt tac act ctt gga cca cta gtt acc gac atc gct cca ggt tat gac 1459Phe Tyr Thr Leu Gly Pro Leu Val Thr Asp Ile Ala Pro Gly Tyr Asp

440 445 450cac atc act tct gcc att ggt gca gct cac atc gcc atg ggt ggc acc 1507His Ile Thr Ser Ala Ile Gly Ala Ala His Ile Ala Met Gly Gly Thr

455 460 465gcc atg ctg tgt tat gtc acc ccg aaa gaa cac ctt ggc ctg ccc aac 1555Ala Met Leu Cys Tyr Val Thr Pro Lys Glu His Leu Gly Leu Pro Asn470 475 480 485cgt gac gac gtc aaa acc ggc gta atc acc tac aag ctc gct gcc cac 1603Arg Asp Asp Val Lys Thr Gly Val Ile Thr Tyr Lys Leu Ala Ala His

490 495 500gca gca gat gtg gcc aag ggt cat ccc ggc gcg cgt gcc tgg gac gac 1651Ala Ala Asp Val Ala Lys Gly His Pro Gly Ala Arg Ala Trp Asp Asp

505 510 515gcc atg agt aaa gcg cgt ttt gaa ttc cgt tgg aat gat cag ttt gcg 1699Ala Met Ser Lys Ala Arg Phe Glu Phe Arg Trp Asn Asp Gln Phe Ala

520 525 530ctc tcc ctc gac ccc gac act gca atc gct tat cac gac gaa acc ctg 1747Leu Ser Leu Asp Pro Asp Thr Ala Ile Ala Tyr His Asp Glu Thr Leu

535 540 545ccg gca gag cct gcg aaa acc gca cac ttc tgt tca atg tgt ggc ccg 1795Pro Ala Glu Pro Ala Lys Thr Ala His Phe Cys Ser Met Cys Gly Pro550 555 560 565aag ttc tgc tcc atg cga att agc cag gac att cgc gat atg ttt ggc 1843Lys Phe Cys Ser Met Arg Ile Ser Gln Asp Ile Arg Asp Met Phe Gly

570 575 580gat caa atc gcg gaa ttg gggatg cct ggg gtt ggg gat tct tct agt 1891Asp Gln Ile Ala Glu Leu Gly Met Pro Gly Val Gly Asp Ser Ser Ser

585 590 595gct gtt gct tct agt ggg gca cgg gag ggg atg gct gag aaa tcc cgg 1939Ala Val Ala Ser Ser Gly Ala Arg Glu Gly Met Ala Glu Lys Ser Arg

600 605 610gaa ttt att gct ggt ggt gcg gag gtt tat cgg cgt tagacagagc 1985Glu Phe Ile Ala Gly Gly Ala Glu Val Tyr Arg Arg

615620625 gatcccagat agc 1998<210>522<211>625<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>522Leu Lys Ala Val Pro Thr Gly Ala Arg Ala Arg Ala Glu Ile Ala Leu 151015 Ile Ala Ala Arg Ala Pro Phe Glu Pro Val Arg Leu Ala Pro Ala Lys

20 25 30Glu Glu Arg Asn Gly Ala Met Thr Pro Thr Gln Asn Glu Ile His Pro

35 40 45Lys His Ser Tyr Ser Pro Ile Arg Lys Asp Gly Leu Glu Val Pro Glu

50 55 60Thr Glu Ile Arg Leu Asp Asp Ser Pro Ser Gly Pro Asn Glu Pro Phe 65 70 75 80Arg Ile Tyr Arg Thr Arg Gly Pro Glu Thr Asn Pro Lys Gln Gly Leu

85 90 95Pro Arg Leu Arg Glu Ser Trp Ile Thr Ala Arg Gly Asp Val Ala Thr

100 105 110Tyr Gln Gly Arg Glu Arg Leu Leu Ile Asp Asp Gly Arg Ser Ala Met

115 120 125Arg Arg Gly Gln Ala Ser Ala Glu Trp Lys Gly Gln Lys Pro Ala Pro

130 135 140Leu Lys Ala Leu Pro Gly Lys Arg Val Thr Gln Met Ala Tyr Ala Arg145 150 155 160Ala Gly Val Ile Thr Arg Glu Met Glu Phe Val Ala Leu Arg Glu His

165 170 175Val Asp Ala Glu Phe Val Arg Ser Glu Val Ala Arg Gly Arg Ala Ile

180 185 190Ile Pro Asn Asn Val Asn His Pro Glu Ser Glu Pro Met Ile Ile Gly

195 200 205Arg Lys Phe Leu Thr Lys Ile Asn Ala Asn Ile Gly Asn Ser Ala Val

210 215 220Thr Ser Ser Ile Glu Glu Glu Val Ser Lys Leu Gln Trp Ala Thr Arg225 230 235 240Trp Gly Ala Asp Thr Val Met Asp Leu Ser Thr Gly Asp Asp Ile His

245 250 255Thr Thr Arg Glu Trp Ile Ile Arg Asn Ser Pro Val Pro Ile Gly Thr

260 265 270Val Pro Ile Tyr Gln Ala Leu Glu Lys Val Asn Gly Val Ala Ala Asp

275 280 285Leu Asn Trp Glu Val Phe Arg Asp Thr Ile Ile Glu Gln Cys Glu Gln

290 295 300Gly Val Asp Tyr Met Thr Ile His Ala Gly Val Leu Leu Ala Tyr Ile305 310 315 320Pro Leu Thr Thr Arg Arg Val Thr Gly Ile Val Ser Arg Gly Gly Ser

325 330 335Ile Met Ala Gly Trp Cys Leu Ala His His Arg Glu Ser Phe Leu Tyr

340 345 350Glu His Phe Asp Glu Leu Cys Glu Ile Phe Ala Gln Tyr Asp Val Ala

355 360 365Phe Ser Leu Gly Asp Gly Leu Arg Pro Gly Ser Leu Ala Asp Ala Asn

370 375 380Asp Ala Ala Gln Phe Ala Glu Leu Lys Thr Ile Gly Glu Leu Thr Gln385 390 395 400Arg Ala Trp Glu Tyr Asp Val Gln Val Met Val Glu Gly Pro Gly His

405 410 415Val Pro Leu Asn Met Ile Gln Glu Asn Asn Glu Leu Glu Gln Lys Trp

420 425 430Ala Ala Asp Ala Pro Phe Tyr Thr Leu Gly Pro Leu Val Thr Asp Ile

435 440 445Ala Pro Gly Tyr Asp His Ile Thr Ser Ala Ile Gly Ala Ala His Ile

450 455 460Ala Met Gly Gly Thr Ala Met Leu Cys Tyr Val Thr Pro Lys Glu His465 470 475 480Leu Gly Leu Pro Asn Arg Asp Asp Val Lys Thr Gly Val Ile Thr Tyr

485 490 495Lys Leu Ala Ala His Ala Ala Asp Val Ala Lys Gly His Pro Gly Ala

500 505 510Arg Ala Trp Asp Asp Ala Met Ser Lys Ala Arg Phe Glu Phe Arg Trp

515 520 525Asn Asp Gln Phe Ala Leu Ser Leu Asp Pro Asp Thr Ala Ile Ala Tyr

530 535 540His Asp Glu Thr Leu Pro Ala Glu Pro Ala Lys Thr Ala His Phe Cys545 550 555 560Ser Met Cys Gly Pro Lys Phe Cys Ser Met Arg Ile Ser Gln Asp Ile

565 570 575Arg Asp Met Phe Gly Asp Gln Ile Ala Glu Leu Gly Met Pro Gly Val

580 585 590Gly Asp Ser Ser Ser Ala Val Ala Ser SerGly Ala Arg Glu Gly Met

595 600 605Ala Glu Lys Ser Arg Glu Phe Ile Ala Gly Gly Ala Glu Val Tyr Arg

610615620 Arg625<210>523<211>1013<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) · (990)<223>RXA01019<400>523act ttg gcg cac tca ctt tca ttc ccg gat tcg ctt cgc gac ggg cca 48Thr Leu Ala His Ser Leu Ser Phe Pro Asp Ser Leu Arg Asp Gly Pro 151015 acc gtt gga gac ctc ggg gaa ttt gaa gtg att cgg gta atc acg gag 96Thr Val Gly Asp Leu Gly Glu Phe Glu Val Ile Arg Val Ile Thr Glu

20 25 30caa gct gga tca tct ctc aac ggc gat gac gca gct gtg ctt cgg cat 144Gln Ala Gly Ser Ser Leu Asn Gly Asp Asp Ala Ala Val Leu Arg His

35 40 45gca tca ccc aat tcc agg gct gtt gtc acc acc gac atg ttg gtt gcg 192Ala Ser Pro Asn Ser Arg Ala Val Val Thr Thr Asp Met Leu Val Ala

50 55 60ggt agg cat ttc caa ttg gat tgg tcc acc ccg gaa caa ata ggg cag 240Gly Arg His Phe Gln Leu Asp Trp Ser Thr Pro Glu Gln Ile Gly Gln 65 70 75 80aag gcg att gtg cag aac ttt gct gat att gag gcg atg ggt gca cgt 288Lys Ala Ile Val Gln Asn Phe Ala Asp Ile Glu Ala Met Gly Ala Arg

85 90 95cca gta gcc gca ttg ttg gcg att tcc gcc ccc aca cac acc ccc gtg 336Pro Val Ala Ala Leu Leu Ala Ile Ser Ala Pro Thr His Thr Pro Val

100 105 110gag ttt gtc cga ggc tta gcc cgt ggc atg aat caa cgc ttg gag gag 384Glu Phe Val Arg Gly Leu Ala Arg Gly Met Asn Gln Arg Leu Glu Glu

115 120 125tac tcc gcg gaa ctt gtt ggc gga gac atc acc agc ggg gac tcc ttg 432Tyr Ser Ala Glu Leu Val Gly Gly Asp Ile Thr Ser Gly Asp Ser Leu

130 135 140gtt att gct gta act gca att ggt caa ctg ggt gga tcc ttg cca gag 480Val Ile Ala Val Thr Ala Ile Gly Gln Leu Gly Gly Ser Leu Pro Glu145 150 155 160ctg acg ttg gga cgt gcc cga cca gga cag acc ctg gtg gcc cac gga 528Leu Thr Leu Gly Arg Ala Arg Pro Gly Gln Thr Leu Val Ala His Gly

165 170 175aag atc ggt tac tcc gca gca ggc ctt gct cta ctg cag cac ttt ggt 576Lys Ile Gly Tyr Ser Ala Ala Gly Leu Ala Leu Leu Gln His Phe Gly

180 185 190cca gac aac gtt cca gag cac ctt cgc ccc ttg gtg gat gca cac tgc 624Pro Asp Asn Val Pro Glu His Leu Arg Pro Leu Val Asp Ala His Cys

195 200 205gca cca gtt ctc acc cca ggc cga ggc atg gtg gca cgc gct gct gga 672Ala Pro Val Leu Thr Pro Gly Arg Gly Met Val Ala Arg Ala Ala Gly

210 215 220gcg acc gcc atg act gat aac tcg gac gga ctg att gtg gat ctt aac 720Ala Thr Ala Met Thr Asp Asn Ser Asp Gly Leu Ile Val Asp Leu Asn225 230 235 240caa atg gcc atg aag tct ggt gtg cgc atc gat gtg gat tcc tgt agc 768Gln Met Ala Met Lys Ser Gly Val Arg Ile Asp Val Asp Ser Cys Ser

245 250 255atc agc ccc gat gaa ctc ctt agc gaa gcc gct tcc gta ctc gga aca 816Ile Ser Pro Asp Glu Leu Leu Ser Glu Ala Ala Ser Val Leu Gly Thr

260 265 270gac gcc tgg cga tgg atc tta agc ggc ggg gaa gac cac acc ctg ctc 864Asp Ala Trp Arg Trp Ile Leu Ser Gly Gly Glu Asp His Thr Leu Leu

275 280 285tct acg acg ttt ggc gat gcc ccc tct gga ttc cgc acc atc ggc caa 912Ser Thr Thr Phe Gly Asp Ala Pro Ser Gly Phe Arg Thr Ile Gly Gln

290 295 300gtc acc aaa aca cgc cac gaa gac ctc gtc acc gta gat aag aaa acc 960Val Thr Lys Thr Arg His Glu Asp Leu Val Thr Val Asp Lys Lys Thr305 310 315 320ccc gca ttt tcc gat gga tgg aga agc ttc taatgaccaa caccctatgg 1010Pro Ala Phe Ser Asp Gly Trp Arg Ser Phe

325330 aat 1013<210>524<211>330<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>524Thr Leu Ala His Ser Leu Ser Phe Pro Asp Ser Leu Arg Asp Gly Pro 151015 Thr Val Gly Asp Leu Gly Glu Phe Glu Val Ile Arg Val Ile Thr Glu

20 25 30Gln Ala Gly Ser Ser Leu Asn Gly Asp Asp Ala Ala Val Leu Arg His

35 40 45Ala Ser Pro Asn Ser Arg Ala Val Val Thr Thr Asp Met Leu Val Ala

50 55 60Gly Arg His Phe Gln Leu Asp Trp Ser Thr Pro Glu Gln Ile Gly Gln 65 70 75 80Lys Ala Ile Val Gln Asn Phe Ala Asp Ile Glu Ala Met Gly Ala Arg

85 90 95Pro Val Ala Ala Leu Leu Ala Ile Ser Ala Pro Thr His Thr Pro Val

100 105 110Glu Phe Val Arg Gly Leu Ala Arg Gly Met Asn Gln Arg Leu Glu Glu

115 120 125Tyr Ser Ala Glu Leu Val Gly Gly Asp Ile Thr Ser Gly Asp Ser Leu

130 135 140Val Ile Ala Val Thr Ala Ile Gly Gln Leu Gly Gly Ser Leu Pro Glu145 150 155 160Leu Thr Leu Gly Arg Ala Arg Pro Gly Gln Thr Leu Val Ala His Gly

165 170 175Lys Ile Gly Tyr Ser Ala Ala Gly Leu Ala Leu Leu Gln His Phe Gly

180 185 190Pro Asp Asn Val Pro Glu His Leu Arg Pro Leu Val Asp Ala His Cys

195 200 205Ala Pro Val Leu Thr Pro Gly Arg Gly Met Val Ala Arg Ala Ala Gly

210 215 220Ala Thr Ala Met Thr Asp Asn Ser Asp Gly Leu Ile Val Asp Leu Asn225 230 235 240Gln Met Ala Met Lys Ser Gly Val Arg Ile Asp Val Asp Ser Cys Ser

245 250 255Ile Ser Pro Asp Glu Leu Leu Ser Glu Ala Ala Ser Val Leu Gly Thr

260 265 270Asp Ala Trp Arg Trp Ile Leu Ser Gly Gly Glu Asp His Thr Leu Leu

275 280 285Ser Thr Thr Phe Gly Asp Ala Pro Ser Gly Phe Arg Thr Ile Gly Gln

290 295 300Val Thr Lys Thr Arg His Glu Asp Leu Val Thr Val Asp Lys Lys Thr305 310 315 320Pro Ala Phe Ser Asp Gly Trp Arg Ser Phe

325330<210>525<211>706<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (706)<223>RXA01352<400>525gtgcccaatg cattgggctg agattgcgcg ctgttgctgc gcgggaccgt tcgaacctgt 60ctggttaaca ccagcgaagg aagcgaggat tgattgtccc gtg ttt gaa aat cgt 115

Val Phe Glu Asn Arg

1 5ttt gac ctg cgt tgt tat gtt gtg act ggt gcg ggc tcg gtg gat gag 163Phe Asp Leu Arg Cys Tyr Val Val Thr Gly Ala Gly Ser Val Asp Glu

10 15 20gtt gtg cac act gcg tct gct gcg gct cgt ggt ggc gcg ggt gtg gtg 211Val Val His Thr Ala Ser Ala Ala Ala Arg Gly Gly Ala Gly Val Val

25 30 35cag gtg cgt tca aag cct att tcg cca gaa gcg atg agg gag ttg gca 259Gln Val Arg Ser Lys Pro Ile Ser Pro Glu Ala Met Arg Glu Leu Ala

40 45 50tca aag gtt gcg ctt gag gtt gcg cgg tgc agc cca aca acg agg gtg 307Ser Lys Val Ala Leu Glu Val Ala Arg Cys Ser Pro Thr Thr Arg Val

55 60 65ctt atc gac gac cac ctc cac gtt gct tct tcc tta atg cgc gaa gga 355Leu Ile Asp Asp His Leu His Val Ala Ser Ser Leu Met Arg Glu Gly 70 75 80 85ctc ccg att cac ggt gtg cat ctt ggg cag gat gat atg tcg gtg ctt 403Leu Pro Ile His Gly Val His Leu Gly Gln Asp Asp Met Ser Val Leu

90 95 100gag gct cgt gag ttg ttg ggg cct gag gcg atc att ggg ttg act act 451Glu Ala Arg Glu Leu Leu Gly Pro Glu Ala Ile Ile Gly Leu Thr Thr

105 110 115gga acc cta gaa ctt gtg gcg gcg gcg aat gag ctg tcc gat gtg ttg 499Gly Thr Leu Glu Leu Val Ala Ala Ala Asn Glu Leu Ser Asp Val Leu

120 125 130gat tac atc ggt gctggg ccg ttt cgg aag act ccc acc aag gat tca 547Asp Tyr Ile Gly Ala Gly Pro Phe Arg Lys Thr Pro Thr Lys Asp Ser

135 140 145ggt cgg cca ccg att ggc ctt gcg ggt tat ccc cct ttg gtg gaa ttg 595Gly Arg Pro Pro Ile Gly Leu Ala Gly Tyr Pro Pro Leu Val Glu Leu150 155 160 165tcc aag gtg ccg atc gtt gcg att ggt gat gtc acc cct gcc gat gtg 643Ser Lys Val Pro Ile Val Ala Ile Gly Asp Val Thr Pro Ala Asp Val

170 175 180cgc gct ctc agc gca acc ggt gtg gct ggc gtt gcc atg gtg cgg gct 691Arg Ala Leu Ser Ala Thr Gly Val Ala Gly Val Ala Met Val Arg Ala

185 190 195ttt tct gaa tct gat 706Phe Ser Glu Ser Asp

200<210>526<211>202<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>526Val Phe Glu Asn Arg Phe Asp Leu Arg Cys Tyr Val Val Thr Gly Ala 151015 Gly Ser Val Asp Glu Val Val His Thr Ala Ser Ala Ala Ala Arg Gly

20 25 30Gly Ala Gly Val Val Gln Val Arg Ser Lys Pro Ile Ser Pro Glu Ala

35 40 45Met Arg Glu Leu Ala Ser Lys Val Ala Leu Glu Val Ala Arg Cys Ser

50 55 60Pro Thr Thr Arg Val Leu Ile Asp Asp His Leu His Val Ala Ser Ser 65 70 75 80Leu Met Arg Glu Gly Leu Pro Ile His Gly Val His Leu Gly Gln Asp

85 90 95Asp Met Ser Val Leu Glu Ala Arg Glu Leu Leu Gly Pro Glu Ala Ile

100 105110Ile Gly Leu Thr Thr Gly Thr Leu Glu Leu Val Ala Ala Ala Asn Glu

115 120 125Leu Ser Asp Val Leu Asp Tyr Ile Gly Ala Gly Pro Phe Arg Lys Thr

130 135 140Pro Thr Lys Asp Ser Gly Arg Pro Pro Ile Gly Leu Ala Gly Tyr Pro145 150 155 160Pro Leu Val Glu Leu Ser Lys Val Pro Ile Val Ala Ile Gly Asp Val

165 170 175Thr Pro Ala Asp Val Arg Ala Leu Ser Ala Thr Gly Val Ala Gly Val

180 185 190Ala Met Val Arg Ala Phe Ser Glu Ser Asp

195200<210>527<211>944<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (921)<223>RXA01381<400>527tcc gca ggc gtt gga acc atc acg gtc atc gat gac gac acc gtc gac 48Ser Ala Gly Val Gly Thr Ile Thr Val Ile Asp Asp Asp Thr Val Asp 151015 att tcc aac att cac cgc caa atc ctc ttc ggc gca agc gat gtc ggt 96Ile Ser Asn Ile His Arg Gln Ile Leu Phe Gly Ala Ser Asp Val Gly

20 25 30cga ccc aag gtc gag gtt gcc gcc gag cgc ctc aaa gaa ctc caa cca 144Arg Pro Lys Val Glu Val Ala Ala Glu Arg Leu Lys Glu Leu Gln Pro

35 40 45gac atc acc gtc aac gcg ttg cac gaa cgg atc act cca gaa aac gcc 192Asp Ile Thr Val Asn Ala Leu His Glu Arg Ile Thr Pro Glu Asn Ala

50 55 60tgc gag ctg ctc aat tcc gtg gac ctc gtc tta gac ggc tcc gat tct 240Cys Glu Leu Leu Asn Ser Val Asp Leu Val Leu Asp Gly Ser Asp Ser 65 70 75 80ttc tcc aca aaa tac tta gtg tct gat gcc gcc gaa atc acc gga act 288Phe Ser Thr Lys Tyr Leu Val Ser Asp Ala Ala Glu Ile Thr Gly Thr

85 90 95ccc ctc atc tgg gca acg gta ctg cgc ttt cac ggc gaa ctg gca ctc 336Pro Leu Ile Trp Ala Thr Val Leu Arg Phe His Gly Glu Leu Ala Leu

100 105 110ttc aac tct ggc ccc gac cac cgc gga gtc ggc ctg cgc gac gtc ttc 384Phe Asn Ser Gly Pro Asp His Arg Gly Val Gly Leu Arg Asp Val Phe

115 120 125ccc gaa caa ccc tcc gcc gat ttc gtc cct gac tgc gcc acc gct ggt 432Pro Glu Gln Pro Ser Ala Asp Phe Val Pro Asp Cys Ala Thr Ala Gly

130 135 140gtt ctt ggc gcc acc aca gcc acc atc ggc gca ctc atg gcc act cac 480Val Leu Gly Ala Thr Thr Ala Thr Ile Gly Ala Leu Met Ala Thr His145 150 155 160gcc atc gga ttt ctc aca gaa atc ggc gac gtc caa cca ggc aca atc 528Ala Ile Gly Phe Leu Thr Glu Ile Gly Asp Val Gln Pro Gly Thr Ile

165 170 175ctc tcc tac gac gca ttc ccc gcc gcc acg cgc agc ttc cgc gtc tcc 576Leu Ser Tyr Asp Ala Phe Pro Ala Ala Thr Arg Ser Phe Arg Val Ser

180 185 190gcc gac ccg gcg cgc cca ctg gtc acc cgc ctc cgc gcc tcc tac gag 624Ala Asp Pro Ala Arg Pro Leu Val Thr Arg Leu Arg Ala Ser Tyr Glu

195 200 205gca gcg cgc acc gat aca act tcg ctt atc gac gcc acc ctc aac ggc 672Ala Ala Arg Thr Asp Thr Thr Ser Leu Ile Asp Ala Thr Leu Asn Gly

210 215 220tcc ctc acc gcc ctc gat atc cga gag cca cat gaa gtt ctg ctc aaa 720Ser Leu Thr Ala Leu Asp Ile Arg Glu Pro His Glu Val Leu Leu Lys225 230 235 240gac ctc ccc gag ggc gca acg tca ctg aag ctc ccc tta agc cag atc 768Asp Leu Pro Glu Gly Ala Thr Ser Leu Lys Leu Pro Leu Ser Gln Ile

245 250 255acc tcg gac agc gac att tta gag gca ctg tct gga atc gac ggc gac 816Thr Ser Asp Ser Asp Ile Leu Glu Ala Leu Ser Gly Ile Asp Gly Asp

260 265 270att ttg gtc tac tgc gct tcg gga atc cgc agt tcc gac ttc atc gac 864Ile Leu Val Tyr Cys Ala Ser Gly Ile Arg Ser Ser Asp Phe Ile Asp

275 280 285aac tac tcc cac ctc ggc cac aaa ttt gtg aat ctt ccc ggt ggg gtc 912Asn Tyr Ser His Leu Gly His Lys Phe Val Asn Leu Pro Gly Gly Val

290295300 aac gcg ctg tagctgtcaa tttaagaggc cag 944Asn Ala Leu305<210>528<211>307<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>528Ser Ala Gly Val Gly Thr Ile Thr Val Ile Asp Asp Asp Thr Val Asp 151015 Ile Ser Asn Ile His Arg Gln Ile Leu Phe Gly Ala Ser Asp Val Gly

20 25 30Arg Pro Lys Val Glu Val Ala Ala Glu Arg Leu Lys Glu Leu Gln Pro

35 40 45Asp Ile Thr Val Asn Ala Leu His Glu Arg Ile Thr Pro Glu Asn Ala

50 55 60Cys Glu Leu Leu Asn Ser Val Asp Leu Val Leu Asp Gly Ser Asp Ser 65 70 75 80Phe Ser Thr Lys Tyr Leu Val Ser Asp Ala Ala Glu Ile Thr Gly Thr

85 90 95Pro Leu Ile Trp Ala Thr Val Leu Arg Phe His Gly Glu Leu Ala Leu

100 105 110Phe Asn Ser Gly Pro Asp His Arg Gly Val Gly Leu Arg Asp Val Phe

115 120 125Pro Glu Gln Pro Ser Ala Asp Phe Val Pro Asp Cys Ala Thr Ala Gly

130 135 140Val Leu Gly Ala Thr Thr Ala Thr Ile Gly Ala Leu Met Ala Thr His145 150 155 160Ala Ile Gly Phe Leu Thr Glu Ile Gly Asp Val Gln Pro Gly Thr Ile

165 170 175Leu Ser Tyr Asp Ala Phe Pro Ala Ala Thr Arg Ser Phe Arg Val Ser

180 185 190Ala Asp Pro Ala Arg Pro Leu Val Thr Arg Leu Arg Ala Ser Tyr Glu

195 200 205Ala Ala Arg Thr Asp Thr Thr Ser Leu Ile Asp Ala Thr Leu Asn Gly

210 215 220Ser Leu Thr Ala Leu Asp Ile Arg Glu Pro His Glu Val Leu Leu Lys225 230 235 240Asp Leu Pro Glu Gly Ala Thr Ser Leu Lys Leu Pro Leu Ser Gln Ile

245 250 255Thr Ser Asp Ser Asp Ile Leu Glu Ala Leu Ser Gly Ile Asp Gly Asp

260 265 270Ile Leu Val Tyr Cys Ala Ser Gly Ile Arg Ser Ser Asp Phe Ile Asp

275 280 285Asn Tyr Ser His Leu Gly His Lys Phe Val Asn Leu Pro Gly Gly Val

290295300 Asn Ala Leu305<210>529<211>259<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (259)<223>RXA01360<400>529gtggcaatca acgccgcggt cgtacccaga tcccagtggt cacgcgccat ttgtgacaac 60gattccgtag aagttctcac cgcaattcag ggaggttaaa atg ctg cat att gct 115

Met Leu His Ile Ala

1 5gat aaa act ttc gat tcc cac ctc atc atg ggc acc ggc gga gcc acc 163Asp Lys Thr Phe Asp Ser His Leu Ile Met Gly Thr Gly Gly Ala Thr

10 15 20tct cag gcg ttg ctg gag gaa tcc ctt gtc gcc agt gga act caa ttg 211Ser Gln Ala Leu Leu Glu Glu Ser Leu Val Ala Ser Gly Thr Gln Leu

25 30 35acc acc gtg gcg atg cgt cga cac caa gca acc acc tct agc gga gaa 259Thr Thr Val Ala Met Arg Arg His Gln Ala Thr Thr Ser Ser Gly Glu

404550<210>530<211>53<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>530Met Leu His Ile Ala Asp Lys Thr Phe Asp Ser His Leu Ile Met Gly 151015 Thr Gly Gly Ala Thr Ser Gln Ala Leu Leu Glu Glu Ser Leu Val Ala

20 25 30Ser Gly Thr Gln Leu Thr Thr Val Ala Met Arg Arg His Gln Ala Thr

35 40 45Thr Ser Ser Gly Glu

50<210>531<211>629<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (606)<223>RXA01361<400>531gcc gac gct gtg atc tct att gat ggc cac gat ccg tgt ttg acc gtg 48Ala Asp Ala Val Ile Ser Ile Asp Gly His Asp Pro Cys Leu Thr Val 151015 acg atg aat tcg ggg gtg agg gtt gcg tcg aaa agc gtt gtt gtt ttg 96Thr Met Asn Ser Gly Val Arg Val Ala Ser Lys Ser Val Val Val Leu

20 2530gcg gcg ggc ctg ggc gcc gca agc att ccc ggc tgg ttt gag ggc gcg 144Ala Ala Gly Leu Gly Ala Ala Ser Ile Pro Gly Trp Phe Glu Gly Ala

35 40 45aac cca ttg cag ttg agg ccg gtg tac ggc gat att gtg cgc gtg cgc 192Asn Pro Leu Gln Leu Arg Pro Val Tyr Gly Asp Ile Val Arg Val Arg

50 55 60gtg ccg gag cga ctg cag ccg atg gtc acc aag gtg gtg cgc ggg ttt 240Val Pro Glu Arg Leu Gln Pro Met Val Thr Lys Val Val Arg Gly Phe 65 70 75 80gtg gaa gat cgt cag att tat atc att ccg cgt acc gat ggc acc ctc 288Val Glu Asp Arg Gln Ile Tyr Ile Ile Pro Arg Thr Asp Gly Thr Leu

85 90 95gcg atc ggc gcg aca agc cgt gag gat cac ccg caa cct cga acg ggc 336Ala Ile Gly Ala Thr Ser Arg Glu Asp His Pro Gln Pro Arg Thr Gly

100 105 110gca gtg cat gat ttg cta cgc gat gct atc cgt ttg att ccg ggc att 384Ala Val His Asp Leu Leu Arg Asp Ala Ile Arg Leu Ile Pro Gly Ile

115 120 125gaa gaa acc gaa ttt atc gaa gtc acc tgc ggc gcc cgc ccc ggc acc 432Glu Glu Thr Glu Phe Ile Glu ValThr Cys Gly Ala Arg Pro Gly Thr

130 135 140ccg gat gac ctg ccg tac ctg gga tgg gtt gga tcc aat gtg att gcg 480Pro Asp Asp Leu Pro Tyr Leu Gly Trp Val Gly Ser Asn Val Ile Ala145 150 155 160tcc aca gga tat ttc cgc cat gga att ttg ctg tca gcc ctt ggt gca 528Ser Thr Gly Tyr Phe Arg His Gly Ile Leu Leu Ser Ala Leu Gly Ala

165 170 175cgc gct gcc gtt gat atg gca acc aac cag cca ctg ttc ccc act ctt 576Arg Ala Ala ValAsp Met Ala Thr Asn Gln Pro Leu Phe Pro Thr Leu

180 185 190gat gtg tgc gat ccg ttt cgc cac caa att taaggatttt tcacaagtga 626Asp Val Cys Asp Pro Phe Arg His Gln Ile

195200 tta 629<210>532<211>202<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>532Ala Asp Ala Val Ile Ser Ile Asp Gly His Asp Pro Cys Leu Thr Val 151015 Thr Met Asn Ser Gly Val Arg Val Ala Ser Lys Ser Val Val Val Leu

20 25 30Ala Ala Gly Leu Gly Ala Ala Ser Ile Pro Gly Trp Phe Glu Gly Ala

35 40 45Asn Pro Leu Gln Leu Arg Pro Val Tyr Gly Asp Ile Val Arg Val Arg

50 55 60Val Pro Glu Arg Leu Gln Pro Met Val Thr Lys Val Val Arg Gly Phe 65 70 75 80Val Glu Asp Arg Gln Ile Tyr Ile Ile Pro Arg Thr Asp Gly Thr Leu

85 90 95Ala Ile Gly Ala Thr Ser Arg Glu Asp His Pro Gln Pro Arg Thr Gly

100 105 110Ala Val His Asp Leu Leu Arg Asp Ala Ile Arg Leu Ile Pro Gly Ile

115 120 125Glu Glu Thr Glu Phe Ile Glu Val Thr Cys Gly Ala Arg Pro Gly Thr

130 135 140Pro Asp Asp Leu Pro Tyr Leu Gly Trp Val Gly Ser Asn Val Ile Ala145 150 155 160Ser Thr Gly Tyr Phe Arg His Gly Ile Leu Leu Ser Ala Leu Gly Ala

165 170 175Arg Ala Ala Val Asp Met Ala Thr Asn Gln Pro Leu Phe Pro Thr Leu

180 185 190Asp Val Cys Asp Pro Phe Arg His Gln Ile

195200<210>533<211>927<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (904)<223>RXA01208<400>533tactaggcac ggggtgccaa ccggatggaa aaattccgga ggctgagaaa acacccgttg 60aacctgctct agctcgtact agcgaaggga tggccttaac gtg gct aac tcg ttt 115

Val Ala Asn Ser Phe

1 5ttg gat tct tta act ctt gtt cga caa aac act ccc ctt gtt cag tgt 163Leu Asp Ser Leu Thr Leu Val Arg Gln Asn Thr Pro Leu Val Gln Cys

10 15 20ttg acc aac tct gtg gtc atg caa ttc acg gcc aat gtg ttg ctt gcc 211Leu Thr Asn Ser Val Val Met Gln Phe Thr Ala Asn Val Leu Leu Ala

25 30 35gcg ggt gcg acc cct gcg atg gtg gat act cca gct gaa tcg gca gaa 259Ala Gly Ala Thr Pro Ala Met Val Asp Thr Pro Ala Glu Ser Ala Glu

40 45 50ttc gcc gct gtg gcc aat gga gtg ctc atc aat gcg gga act cct tct 307Phe Ala Ala Val Ala Asn Gly Val Leu Ile Asn Ala Gly Thr Pro Ser

55 60 65gcg gag caa tac caa ggc atg acc aag gcc att gag ggt gca cga aaa 355Ala Glu Gln Tyr Gln Gly Met Thr Lys Ala Ile Glu Gly Ala Arg Lys 70 75 80 85gct ggc aca cca tgg gtg tta gac cca gtt gct gtg ggt ggg ttg tcg 403Ala Gly Thr Pro Trp Val Leu Asp Pro Val Ala Val Gly Gly Leu Ser

90 95 100gag agg acc aag tat gcg gag gga atc gtc gat aag cag cct gcc gca 451Glu Arg Thr Lys Tyr Ala Glu Gly Ile Val Asp Lys Gln Pro Ala Ala

105 110 115att cgt gga aac gcc tca gag gtc gtg gcg ctt gcg ggg ctc ggt gcc 499Ile Arg Gly Asn Ala Ser Glu Val Val Ala Leu Ala Gly Leu Gly Ala

120 125 130ggt ggg cgc ggc gta gac gcg acc gat tcc gtg gaa gtg gcg ttg gag 547Gly Gly Arg Gly Val Asp Ala Thr Asp Ser Val Glu Val Ala Leu Glu

135 140 145gcg gcg caa ttg ttg gcc aag cgc act ggt ggc gtc gtg gct gtc tct 595Ala Ala Gln Leu Leu Ala Lys Arg Thr Gly Gly Val Val Ala Val Ser150 155 160 165ggt gcg gag gac ttg att gtg tct gcg gat cgg gtg acg tgg ttg cgt 643Gly Ala Glu Asp Leu Ile Val Ser Ala Asp Arg Val Thr Trp Leu Arg

170 175 180tcg ggg gat ccg atg ttg cag ctg gtg att ggc act gga tgc tct ttg 691Ser Gly Asp Pro Met Leu Gln Leu Val Ile Gly Thr Gly Cys Ser Leu

185 190 195ggc gcg ctg aca gct gca tat cta ggc gcc acg gtt gac tca gat att 739Gly Ala Leu Thr Ala Ala Tyr Leu Gly Ala Thr Val Asp Ser Asp Ile

200 205 210tcc gcg cac gat gct gtg ttg gct gcg cat gcc cat gtg ggt gct gct 787Ser Ala His Asp Ala Val Leu Ala Ala His Ala His Val Gly Ala Ala

215 220 225ggc cag att gca gca cag aag gca tcg gcg cca ggc agc ttt gcg gtg 835Gly Gln Ile Ala Ala Gln Lys Ala Ser Ala Pro Gly Ser Phe Ala Val230 235 240 245gcg ttt att gat gcg ctt tat gac gtg gat gcc cag gct gtg gcc tcg 883Ala Phe Ile Asp Ala Leu Tyr Asp Val Asp Ala Gln Ala Val Ala Ser

250 255 260ttg gtt gat gtg cga gag gcc tgaaaagtac gtgactgatt ttt 927Leu Val Asp Val Arg Glu Ala

265<210>534<211>268<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>534Val Ala Asn Ser Phe Leu Asp Ser Leu Thr Leu Val Arg Gln Asn Thr 151015 Pro Leu Val Gln Cys Leu Thr Asn Ser Val Val Met Gln Phe Thr Ala

20 25 30Asn Val Leu Leu Ala Ala Gly Ala Thr Pro Ala Met Val Asp Thr Pro

35 40 45Ala Glu Ser Ala Glu Phe Ala Ala Val Ala Asn Gly Val Leu Ile Asn

50 55 60Ala Gly Thr Pro Ser Ala Glu Gln Tyr Gln Gly Met Thr Lys Ala Ile 65 70 75 80Glu Gly Ala Arg Lys Ala Gly Thr Pro Trp Val Leu Asp Pro Val Ala

85 90 95Val Gly Gly Leu Ser Glu Arg Thr Lys Tyr Ala Glu Gly Ile Val Asp

100 105 110Lys Gln Pro Ala Ala Ile Arg Gly Asn Ala Ser Glu Val Val Ala Leu

115 120 125Ala Gly Leu Gly Ala Gly Gly Arg Gly Val Asp Ala Thr Asp Ser Val

130 135 140Glu Val Ala Leu Glu Ala Ala Gln Leu Leu Ala Lys Arg Thr Gly Gly145 150 155 160Val Val Ala Val Ser Gly Ala Glu Asp Leu Ile Val Ser Ala Asp Arg

165 170 175Val Thr Trp Leu Arg Ser Gly Asp Pro Met Leu Gln Leu Val Ile Gly

180 185 190ThrGly Cys Ser Leu Gly Ala Leu Thr Ala Ala Tyr Leu Gly Ala Thr

195 200 205Val Asp Ser Asp Ile Ser Ala His Asp Ala Val Leu Ala Ala His Ala

210 215 220His Val Gly Ala Ala Gly Gln Ile Ala Ala Gln Lys Ala Ser Ala Pro225 230 235 240Gly Ser Phe Ala Val Ala Phe Ile Asp Ala Leu Tyr Asp Val Asp Ala

245 250 255Gln Ala Val Ala Ser Leu Val Asp Val Arg Glu Ala

260265<210>535<211>1023<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1000)<223>RXA00838<400>535tcgtctaata gtgctgccaa tccaccggcc attgatgact cctttgtaga gaaggggtag 60tgcttacaaa tcttatctgt gctcaggcaa gatagcaggt atg aaa att gcg atc 115

Met Lys Ile Ala Ile

1 5gtt ggc gct ggt gca gtt ggt gga tat ttc gga gcg ttg tta caa gaa 163Val Gly Ala Gly Ala Val Gly Gly Tyr Phe Gly Ala Leu Leu Gln Glu

10 15 20tct ggt gca gat atc acg atg gtt gca cgt gga cga aca tta gaa gcc 211Ser Gly Ala Asp Ile Thr Met Val Ala Arg Gly Arg Thr Leu Glu Ala

25 30 35ttg aag tct aaa gga ctc cac atc aac gat gca aga ggc gaa cgc tac 259Leu Lys Ser Lys Gly Leu His Ile Asn Asp Ala Arg Gly Glu Arg Tyr

40 45 50gta cca att cct gca gtt gcg agc gtg caa gaa cta aaa gat gca gat 307Val Pro Ile Pro Ala Val Ala Ser Val Gln Glu Leu Lys Asp Ala Asp

55 60 65gta gtg atg att gct act aaa gca tta tcg cgg tct tta gat ctc gct 355Val Val Met Ile Ala Thr Lys Ala Leu Ser Arg Ser Leu Asp Leu Ala 70 75 80 85gaa ctt ttg ggt ggg ata cct gcg aat tcg gtg gtc gcg att act cag 403Glu Leu Leu Gly Gly Ile Pro Ala Asn Ser Val Val Ala Ile Thr Gln

90 95 100aat tcg att gaa tct gct gat cta gca gcg aag agt atc ggt gct gat 451Asn Ser Ile Glu Ser Ala Asp Leu Ala Ala Lys Ser Ile Gly Ala Asp

105 110 115cgt gtg tgg cct ggt gtg gtt cgt ggg ttc ttt gtt cat gag ggg cca 499Arg Val Trp Pro Gly Val Val Arg Gly Phe Phe Val His Glu Gly Pro

120 125 130gcc tca gtg tca tac aag gga ggc cca ctg tcc tac acg ttt ggt gat 547Ala Ser Val Ser Tyr Lys Gly Gly Pro Leu Ser Tyr Thr Phe Gly Asp

135 140 145tct ggt gaa ctt tct agg caa ttc gca agc act ctt gaa cag gcc ggt 595Ser Gly Glu Leu Ser Arg Gln Phe Ala Ser Thr Leu Glu Gln Ala Gly150 155 160 165att gac gga gtt ctg cat ccc gat att ttg gtg gat gtg tgg gag aaa 643Ile Asp Gly Val Leu His Pro Asp Ile Leu Val Asp Val Trp Glu Lys

170 175 180gcc atg ttc gta gag gtt ttc ggc ggg ttg ggg gct ttc gtc gaa aag 691Ala Met Phe Val Glu Val Phe Gly Gly Leu Gly Ala Phe Val Glu Lys

185 190 195caa tta ggt acc ttg cgt acg cat ttt agg gct tcc ctg gaa gcc ttg 739Gln Leu Gly Thr Leu Arg Thr His Phe Arg Ala Ser Leu Glu Ala Leu

200 205 210atg gaa gag gtg gct gag gtg gct cgc gcg gcaggt gtt gcg ttg ccg 787Met Glu Glu Val Ala Glu Val Ala Arg Ala Ala Gly Val Ala Leu Pro

215 220 225agc gat gcg gtg gag cgc acc atg aat ttt gcg gat cgg atg cct gag 835Ser Asp Ala Val Glu Arg Thr Met Asn Phe Ala Asp Arg Met Pro Glu230 235 240 245aat tcg acg agt tcg atg cag cgt gat ttg gcc gcg gga gtg gct agt 883Asn Ser Thr Ser Ser Met Gln Arg Asp Leu Ala Ala Gly Val Ala Ser

250 255 260gag ctt gag gct cag aca ggt gca att gtg cgg gca gcg cac aaa gtg 931Glu Leu Glu Ala Gln Thr Gly Ala Ile Val Arg Ala Ala His Lys Val

265 270 275ggt gtg aaa act ccg ctt cat gac ctt att tat gct ggt ctt aag ctg 979Gly Val Lys Thr Pro Leu His Asp Leu Ile Tyr Ala Gly Leu Lys Leu

280 285 290aaa gaa gag gaa aat tca ctt tagggataga atcaagatcc atg 1023Lys Glu Glu Glu Asn Ser Leu

295300<210>536<211>300<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>536Met Lys Ile Ala Ile Val Gly Ala Gly Ala Val Gly Gly Tyr Phe Gly 151015 Ala Leu Leu Gln Glu Ser Gly Ala Asp Ile Thr Met Val Ala Arg Gly

20 25 30Arg Thr Leu Glu Ala Leu Lys Ser Lys Gly Leu His Ile Asn Asp Ala

35 40 45Arg Gly Glu Arg Tyr Val Pro Ile Pro Ala Val Ala Ser Val Gln Glu

50 55 60Leu Lys Asp Ala Asp Val Val Met Ile Ala Thr Lys Ala Leu Ser Arg 65 70 75 80Ser Leu Asp Leu Ala Glu Leu Leu Gly Gly Ile Pro Ala Asn Ser Val

85 90 95Val Ala Ile Thr Gln Asn Ser Ile Glu Ser Ala Asp Leu Ala Ala Lys

100 105 110Ser Ile Gly Ala Asp Arg Val Trp Pro Gly Val Val Arg Gly Phe Phe

115 120 125Val His Glu Gly Pro Ala Ser Val Ser Tyr Lys Gly Gly Pro Leu Ser

130 135 140Tyr Thr Phe Gly Asp Ser Gly Glu Leu Ser Arg Gln Phe Ala Ser Thr145 150 155 160Leu Glu Gln Ala Gly Ile Asp Gly Val Leu His Pro Asp Ile Leu Val

165 170 175Asp Val Trp Glu Lys Ala Met Phe Val Glu Val Phe Gly Gly Leu Gly

180 185 190Ala Phe Val Glu Lys Gln Leu Gly Thr Leu Arg Thr His Phe Arg Ala

195 200 205Ser Leu Glu Ala Leu Met Glu Glu Val Ala Glu Val Ala Arg Ala Ala

210 215 220Gly Val Ala Leu Pro Ser Asp Ala Val Glu Arg Thr Met Asn Phe Ala225 230 235 240Asp Arg Met Pro Glu Asn Ser Thr Ser Ser Met Gln Arg Asp Leu Ala

245 250 255Ala Gly Val Ala Ser Glu Leu Glu Ala Gln Thr Gly Ala Ile Val Arg

260 265 270Ala Ala His Lys Val Gly Val Lys Thr Pro Leu His Asp Leu Ile Tyr

275 280 285Ala Gly Leu Lys Leu Lys Glu Glu Glu Asn Ser Leu

290295300<210>537<211>693<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (670)<223>RXA02400<400>537aggtgccccc aacgttgcct gttgactgca aattttccga aagaatccat aaactacttc 60tttaagtcgc cagattaaag tcgtcaatga aaggacatac atg tct att tcc cgc 115

Met Ser Ile Ser Arg

1 5acc gtc ttc ggc atc gca gcc acc gca gcc ctg tct gca gct ctc gtt 163Thr Val Phe Gly Ile Ala Ala Thr Ala Ala Leu Ser Ala Ala Leu Val

10 15 20gcg tgt tct cca cct cac cag cag gat tcc cca gtc cag cgc acc aat 211Ala Cys Ser Pro Pro His Gln Gln Asp Ser Pro Val Gln Arg Thr Asn

25 30 35gag atc ttg act act tct cag aac cca act tct gcg agc agc acc tca 259Glu Ile Leu Thr Thr Ser Gln Asn Pro Thr Ser Ala Ser Ser Thr Ser

40 45 50acc tct tcc gca acg act act tcc tca gct cct gtg gaa gag gac gta 307Thr Ser Ser Ala Thr Thr Thr Ser Ser Ala Pro Val Glu Glu Asp Val

55 60 65gag atc gtt gtt tca cca gca gcg ttg gtg gac ggt gag cag gtt acc 355Glu Ile Val Val Ser Pro Ala Ala Leu Val Asp Gly Glu Gln Val Thr 70 75 80 85ttc gaa atc tct gga ctt gat cca gag ggc ggc tac tac gca gcg atc 403Phe Glu Ile Ser Gly Leu Asp Pro Glu Gly Gly Tyr Tyr Ala Ala Ile

90 95 100tgc gat tcc gta gcg aac cct ggt aac cca gtt cct tct tgc acc ggc 451Cys Asp Ser Val Ala Asn Pro Gly Asn Pro Val Pro Ser Cys Thr Gly

105 110 115gaa atg gct gat ttc acg tcc cag gca tgg ttg agc aac tcc cag ccc 499Glu Met Ala Asp Phe Thr Ser Gln Ala Trp Leu Ser Asn Ser Gln Pro

120 125 130ggc gcg act gta gag atc gca gaa gac ggc acc gca act gtg gag ctt 547Gly Ala Thr Val Glu Ile Ala Glu Asp Gly Thr Ala Thr Val Glu Leu

135 140 145gaa gct acc gca acc ggc act ggc ttg gac tgc acc act cag gct tgt 595Glu Ala Thr Ala Thr Gly Thr Gly Leu Asp Cys Thr Thr Gln Ala Cys150 155 160 165gta gcg aag gtc ttc ggc gat cat acc gaa ggt ttc cgc gat gtt gct 643Val Ala Lys Val Phe Gly Asp His Thr Glu Gly Phe Arg Asp Val Ala

170 175 180gaa gtc cca gtt act ttc gca gcc gct taagttttct taaaacgcac 690Glu Val Pro Val Thr Phe Ala Ala Ala

185190 tca 693<210>538<211>190<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>538Met Ser Ile Ser Arg Thr Val Phe Gly Ile Ala Ala Thr Ala Ala Leu 151015 Ser Ala Ala Leu Val Ala Cys Ser Pro Pro His Gln Gln Asp Ser Pro

20 25 30Val Gln Arg Thr Asn Glu Ile Leu Thr Thr Ser Gln Asn Pro Thr Ser

35 40 45Ala Ser Ser Thr Ser Thr Ser Ser Ala Thr Thr Thr Ser Ser Ala Pro

50 55 60Val Glu Glu Asp Val Glu Ile Val Val Ser Pro Ala Ala Leu Val Asp 65 70 75 80Gly Glu Gln Val Thr Phe Glu Ile Ser Gly Leu Asp Pro Glu Gly Gly

85 90 95Tyr Tyr Ala Ala Ile Cys Asp Ser Val Ala Asn Pro Gly Asn Pro Val

100 105 110Pro Ser Cys Thr GlyGlu Met Ala Asp Phe Thr Ser Gln Ala Trp Leu

115 120 125Ser Asn Ser Gln Pro Gly Ala Thr Val Glu Ile Ala Glu Asp Gly Thr 130 135 140Ala Thr Val Glu Leu Glu Ala Thr Ala Thr Gly Thr Gly Leu Asp Cys145 150 155 160Thr Thr Gln Ala Cys Val Ala Lys Val Phe Gly Asp His Thr Glu Gly

165 170 175Phe Arg Asp Val Ala Glu Val Pro Val Thr Phe Ala Ala Ala

180185190<210>539<211>1528<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1528)<223>RXN01209<400>539cagattgcag cacagaaggc atcggcgcca ggcagctttg cggtggcgtt tattgatgcg 60ctttatgacg tggatgccca ggctgtggcc tcgttggttg atg tgc gag agg cct 115

Met Cys Glu Arg Pro

1 5gaa aag tac gtg act gat ttt tct ttg tat ctg gtc acc gat ccc gtt 163Glu Lys Tyr Val Thr Asp Phe Ser Leu Tyr Leu Val Thr Asp Pro Val

10 15 20ttg ggt ggc ggg cca aaa aaa gta gct gga att gtt gac agc gca att 211Leu Gly Gly Gly Pro Lys Lys Val Ala Gly Ile Val Asp Ser Ala Ile

25 30 35tcc ggc gga gtt tct gtg gtg cag ctg cgc gat aag aac tca ggc gtg 259Ser Gly Gly Val Ser Val Val Gln Leu Arg Asp Lys Asn Ser Gly Val

40 45 50gaa gat gtt cgt gcg gca gca aag gag ctg aaa gaa ctc tgc gat gct 307Glu Asp Val Arg Ala Ala Ala Lys Glu Leu Lys Glu Leu Cys Asp Ala

55 6065cgc ggg gtg gcg ctt gtt gtc aac gat tac tta gat atc gcc gtt gag 355Arg Gly Val Ala Leu Val Val Asn Asp Tyr Leu Asp Ile Ala Val Glu 70 75 80 85ctg ggt ctt cac ctg cac att ggt caa ggc gat aca cct tat acg caa 403Leu Gly Leu His Leu His Ile Gly Gln Gly Asp Thr Pro Tyr Thr Gln

90 95 100gca cgg gag ctg ctt cca gct cat ctt gaa ttg ggt ttg agc att gaa 451Ala Arg Glu Leu Leu Pro Ala His Leu Glu Leu Gly Leu Ser Ile Glu

105 110 115aac ctg gat caa ttg cat gct gtg atc gcg cag tgc gcc gag act ggt 499Asn Leu Asp Gln Leu His Ala Val Ile Ala Gln Cys Ala Glu Thr Gly

120 125 130gtg gca ttg ccc gat gtg att ggc att ggt ccg gtg gcc tct act gcg 547Val Ala Leu Pro Asp Val Ile Gly Ile Gly Pro Val Ala Ser Thr Ala

135 140 145acc aaa cca gat gcg gca ccc gca ttg ggt gtg gag ggc atc gct gag 595Thr Lys Pro Asp Ala Ala Pro Ala Leu Gly Val Glu Gly Ile Ala Glu150 155 160 165atc gcc gct gta gct caa gac cac ggc atc gca tca gta gct att gga 643Ile Ala Ala Val Ala Gln Asp His Gly Ile Ala Ser Val Ala Ile Gly

170 175 180ggc gtt ggt cta cgc aac gcg gcc gaa ctc gct gct acg ccc atc gac 691Gly Val Gly Leu Arg Asn Ala Ala Glu Leu Ala Ala Thr Pro Ile Asp

185 190 195ggt ctg tgc gtg gtc tct gaa atc atg acc gcc gcc aat cca gca gct 739Gly Leu Cys Val Val Ser Glu Ile Met Thr Ala Ala Asn Pro Ala Ala

200 205 210gcg gca act cgc ctg cgg act gct ttt caa cct act ttc tcg cct gaa 787Ala Ala Thr ArgLeu Arg Thr Ala Phe Gln Pro Thr Phe Ser Pro Glu

215 220 225act caa act gaa ctc tct caa aca gaa ctc caa gga gcc ttc gtg aat 835Thr Gln Thr Glu Leu Ser Gln Thr Glu Leu Gln Gly Ala Phe Val Asn230 235 240 245tcg cct tct gcc cca cgt gtg ttg tct att gca ggc act gat ccc aca 883Ser Pro Ser Ala Pro Arg Val Leu Ser Ile Ala Gly Thr Asp Pro Thr

250 255 260ggt ggt gca ggt att cag gct gat ctg aag tcc att gca gca ggt ggc 931Gly Gly Ala Gly Ile Gln Ala Asp Leu Lys Ser Ile Ala Ala Gly Gly

265 270 275ggc tac ggc atg tgc gtt gtg acc tcg ctg gtc gcg caa aac acc cac 979Gly Tyr Gly Met Cys Val Val Thr Ser Leu Val Ala Gln Asn Thr His

280 285 290ggc gtc aac acg atc cac acc cca ccc ttg acc ttt ttg gaa gaa cag 1027Gly Val Asn Thr Ile His Thr Pro Pro Leu Thr Phe Leu Glu Glu Gln

295 300 305ctg gaa gcg gtc ttt tcc gat gtc acc gtc gat gcc atc aag ctc ggc 1075Leu Glu Ala Val Phe Ser Asp Val Thr Val Asp Ala Ile Lys Leu Gly310 315 320 325atg ttg ggc tct gcc gac acc gtc gat ctg gtg gct tca tgg ctt ggt 1123Met Leu Gly Ser Ala Asp Thr Val Asp Leu Val Ala Ser Trp Leu Gly

330 335 340tcc cac gag cac ggt ccc gtg gtg ctt gat ccc gtc atg atc gcc acc 1171Ser His Glu His Gly Pro Val Val Leu Asp Pro Val Met Ile Ala Thr

345 350 355agc ggt gat cgc cta ctg gat gcg agc gct gaa gaa tcg ctg cgc cgc 1219Ser Gly Asp Arg Leu Leu Asp Ala Ser Ala Glu Glu Ser Leu Arg Arg

360365 370ctg gcc gtg cac gtc gat gtg gtc acc ccg aat atc ccc gaa ctt gcc 1267Leu Ala Val His Val Asp Val Val Thr Pro Asn Ile Pro Glu Leu Ala

375 380 385gtg ttg tgc gac agt gct cct gcc atc acc atg gat gag gcc att gct 1315Val Leu Cys Asp Ser Ala Pro Ala Ile Thr Met Asp Glu Ala Ile Ala390 395 400 405cag gct cag gga ttt gcg cgg act cat gac acc atc gtc att gtc aag 1363Gln Ala Gln Gly Phe Ala Arg Thr His Asp Thr Ile Val Ile Val Lys

410 415 420ggt gga cat ctg act ggc gcg ctt gct gat aac gct gtc gtg cgc ccc 1411Gly Gly His Leu Thr Gly Ala Leu Ala Asp Asn Ala Val Val Arg Pro

425 430 435gac ggc tcg gtg ttc cag gtg gaa aac ctg cgt gtc aac acc acc aac 1459Asp Gly Ser Val Phe Gln Val Glu Asn Leu Arg Val Asn Thr Thr Asn

440 445 450tcc cat ggc aca ggc tgt tcg ctc tct gcg tca ctt gcc acc aag atc 1507Ser His Gly Thr Gly Cys Ser Leu Ser Ala Ser Leu Ala Thr Lys Ile

455460465 gcc gcc ggc gaa agc gtg gaa 1528Ala Ala Gly Glu Ser Val Glu 470475<210>540<211>476<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>540Met Cys Glu Arg Pro Glu Lys Tyr Val Thr Asp Phe Ser Leu Tyr Leu 151015 Val Thr Asp Pro Val Leu Gly Gly Gly Pro Lys Lys Val Ala Gly Ile

20 25 30Val Asp Ser Ala Ile Ser Gly Gly Val Ser Val Val Gln Leu Arg Asp

35 40 45Lys Asn Ser Gly Val Glu Asp Val Arg Ala Ala Ala Lys Glu Leu Lys

50 55 60Glu Leu Cys Asp Ala Arg Gly Val Ala Leu Val Val Asn Asp Tyr Leu 65 70 75 80Asp Ile Ala Val Glu Leu Gly Leu His Leu His Ile Gly Gln Gly Asp

85 90 95Thr Pro Tyr Thr Gln Ala Arg Glu Leu Leu Pro Ala His Leu Glu Leu

100 105 110Gly Leu Ser Ile Glu Asn Leu Asp Gln Leu His Ala Val Ile Ala Gln

115 120 125Cys Ala Glu Thr Gly Val Ala Leu Pro Asp Val Ile Gly Ile Gly Pro

130 135 140Val Ala Ser Thr Ala Thr Lys Pro Asp Ala Ala Pro Ala Leu Gly Val145 150 155 160Glu Gly Ile Ala Glu Ile Ala Ala Val Ala Gln Asp His Gly Ile Ala

165 170 175Ser Val Ala Ile Gly Gly Val Gly Leu Arg Asn Ala Ala Glu Leu Ala

180 185 190Ala Thr Pro Ile Asp Gly Leu Cys Val Val Ser Glu Ile Met Thr Ala

195 200 205Ala Asn Pro Ala Ala Ala Ala Thr Arg Leu Arg Thr Ala Phe Gln Pro

210 215 220Thr Phe Ser Pro Glu Thr Gln Thr Glu Leu Ser Gln Thr Glu Leu Gln225 230 235 240Gly Ala Phe Val Asn Ser Pro Ser Ala Pro Arg Val Leu Ser Ile Ala

245 250 255Gly Thr Asp Pro Thr Gly Gly Ala Gly Ile Gln Ala Asp Leu Lys Ser

260 265 270Ile Ala Ala Gly Gly Gly Tyr Gly Met Cys Val Val Thr Ser Leu Val

275 280 285Ala Gln Asn Thr His Gly Val Asn Thr Ile His Thr Pro Pro Leu Thr

290 295 300Phe Leu Glu Glu Gln Leu Glu Ala Val Phe Ser Asp Val Thr Val Asp305 310 315 320Ala Ile Lys Leu Gly Met Leu Gly Ser Ala Asp Thr Val Asp Leu Val

325 330 335Ala Ser Trp Leu Gly Ser His Glu His Gly Pro Val Val Leu Asp Pro

340 345 350Val Met Ile Ala Thr Ser Gly Asp Arg Leu Leu Asp Ala Ser Ala Glu

355 360 365Glu Ser Leu Arg Arg Leu Ala Val His Val Asp Val Val Thr Pro Asn

370 375 380Ile Pro Glu Leu Ala Val Leu Cys Asp Ser Ala Pro Ala Ile Thr Met385 390 395 400Asp Glu Ala Ile Ala Gln Ala Gln Gly Phe Ala Arg Thr His Asp Thr

405 410 415Ile Val Ile Val Lys Gly Gly His Leu Thr Gly Ala Leu Ala Asp Asn

420 425 430Ala Val Val Arg Pro Asp Gly Ser Val Phe Gln Val Glu Asn Leu Arg

435 440 445Val Asn Thr Thr Asn Ser His Gly Thr Gly Cys Ser Leu Ser Ala Ser

450455460 Leu Ala Thr Lys Ile Ala Ala Gly Glu Ser Val Glu 465470475<210>541<211>1528<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1528)<223>FRXA01209<400>541cagattgcag cacagaaggc atcggcgcca ggcagctttg cggtggcgtt tattgatgcg 60ctttatgacg tggatgccca ggctgtggcc tcgttggttg atg tgc gag agg cct 115

Met Cys Glu Arg Pro

1 5gaa aag tac gtg act gat ttt tct ttg tat ctg gtc acc gat ccc gtt 163Glu Lys Tyr Val Thr Asp Phe Ser Leu Tyr Leu Val Thr Asp Pro Val

10 15 20ttg ggt ggc ggg cca aaa aaa gta gct gga att gtt gac agc gca att 211Leu Gly Gly Gly Pro Lys Lys Val Ala Gly Ile Val Asp Ser Ala Ile

25 30 35tcc ggc gga gtt tct gtg gtg cag ctg cgc gat aag aac tca ggc gtg 259Ser Gly Gly Val Ser Val Val Gln Leu Arg Asp Lys Asn Ser Gly Val

40 45 50gaa gat gtt cgt gcg gca gca aag gag ctg aaa gaa ctc tgc gat gct 307Glu Asp Val Arg Ala Ala Ala Lys Glu Leu Lys Glu Leu Cys Asp Ala

55 60 65cgc ggg gtg gcg ctt gtt gtc aac gat tac tta gat atc gcc gtt gag 355Arg Gly Val Ala Leu Val Val Asn Asp Tyr Leu Asp Ile Ala Val Glu 70 75 80 85ctg ggt ctt cac ctg cac att ggt caa ggc gat aca cct tat acg caa 403Leu Gly Leu His Leu His Ile Gly Gln Gly Asp Thr Pro Tyr Thr Gln

90 95 100gca cgg gag ctg ctt cca gct cat ctt gaa ttg ggt ttg agc att gaa 451Ala Arg Glu Leu Leu Pro Ala His Leu Glu Leu Gly Leu Ser Ile Glu

105 110 115aac ctg gat caa ttg cat gct gtg atc gcg cag tgc gcc gag act ggt 499Asn Leu Asp Gln Leu His Ala Val Ile Ala Gln Cys Ala Glu Thr Gly

120 125 130gtg gca ttg ccc gat gtg att ggc att ggt ccg gtg gcc tct act gcg 547Val Ala Leu Pro Asp Val Ile Gly Ile Gly Pro Val Ala Ser Thr Ala

135 140 145acc aaa cca gat gcg gca ccc gca ttg ggt gtg gag ggc atc gct gag 595Thr Lys Pro Asp Ala Ala Pro Ala Leu Gly Val Glu Gly Ile Ala Glu150 155 160 165atc gcc gct gta gct caa gac cac ggc atc gca tca gta gct att gga 643Ile Ala Ala Val Ala Gln Asp His Gly Ile Ala Ser Val Ala Ile Gly

170 175 180ggc gtt ggt cta cgc aac gcg gcc gaa ctc gct gct acg ccc atc gac 691Gly Val Gly Leu Arg Asn Ala Ala Glu Leu Ala Ala Thr Pro Ile Asp

185 190 195ggt ctg tgc gtg gtc tct gaa atc atg acc gcc gcc aat cca gca gct 739Gly Leu Cys Val Val Ser Glu Ile Met Thr Ala Ala Asn Pro Ala Ala

200 205 210gcg gca act cgc ctg cgg act gct ttt caa cct act ttc tcg cct gaa 787Ala Ala Thr Arg Leu Arg Thr Ala Phe Gln Pro Thr Phe Ser Pro Glu

215 220 225act caa act gaa ctc tct caa aca gaa ctc caa gga gcc ttc gtg aat 835Thr Gln Thr Glu Leu Ser Gln Thr Glu Leu Gln Gly Ala Phe Val Asn230 235 240 245tcg cct tct gcc cca cgt gtg ttg tct att gca ggc act gat ccc aca 883Ser Pro Ser Ala Pro Arg Val Leu Ser Ile Ala Gly Thr Asp Pro Thr

250 255 260ggt ggt gca ggt att cag gct gat ctg aag tcc att gca gca ggt ggc 931Gly Gly Ala Gly Ile Gln Ala Asp Leu Lys Ser Ile Ala Ala Gly Gly

265 270 275ggc tac ggc atg tgc gtt gtg acc tcg ctg gtc gcg caa aac acc cac 979Gly Tyr Gly Met Cys Val Val Thr Ser Leu Val Ala Gln Asn Thr His

280 285 290ggc gtc aac acg atc cac acc cca ccc ttg accttt ttg gaa gaa cag 1027Gly Val Asn Thr Ile His Thr Pro Pro Leu Thr Phe Leu Glu Glu Gln

295 300 305ctg gaa gcg gtc ttt tcc gat gtc acc gtc gat gcc atc aag ctc ggc 1075Leu Glu Ala Val Phe Ser Asp Val Thr Val Asp Ala Ile Lys Leu Gly310 315 320 325atg ttg ggc tct gcc gac acc gtc gat ctg gtg gct tca tgg ctt ggt 1123Met Leu Gly Ser Ala Asp Thr Val Asp Leu Val Ala Ser Trp Leu Gly

330 335 340tcc cac gag cac ggt ccc gtg gtg ctt gat ccc gtc atg atc gcc acc 1171Ser His Glu His Gly Pro Val Val Leu Asp Pro Val Met Ile Ala Thr

345 350 355agc ggt gat cgc cta ctg gat gcg agc gct gaa gaa tcg ctg cgc cgc 1219Ser Gly Asp Arg Leu Leu Asp Ala Ser Ala Glu Glu Ser Leu Arg Arg

360 365 370ctg gcc gtg cac gtc gat gtg gtc acc ccg aat atc ccc gaa ctt gcc 1267Leu Ala Val His Val Asp Val Val Thr Pro Asn Ile Pro Glu Leu Ala

375 380 385gtg ttg tgc gac agt gct cct gcc atc acc atg gat gag gcc att gct 1315Val Leu Cys Asp Ser Ala Pro Ala Ile Thr Met Asp Glu Ala Ile Ala390 395 400 405cag gct cag gga ttt gcg cgg act cat gac acc atc gtc att gtc aag 1363Gln Ala Gln Gly Phe Ala Arg Thr His Asp Thr Ile Val Ile Val Lys

410 415 420ggt gga cat ctg act ggc gcg ctt gct gat aac gct gtc gtg cgc ccc 1411Gly Gly His Leu Thr Gly Ala Leu Ala Asp Asn Ala Val Val Arg Pro

425 430 435gac ggc tcg gtg ttc cag gtg gaa aac ctg cgt gtc aac acc acc aac 1459Asp Gly Ser Val Phe Gln Val Glu Asn Leu Arg Val Asn Thr Thr Asn

440 445 450tcc cat ggc aca ggc tgt tcg ctc tct gcg tca ctt gcc acc aag atc 1507Ser His Gly Thr Gly Cys Ser Leu Ser Ala Ser Leu Ala Thr Lys Ile

455460465 gcc gcc ggc gaa agc gtg gaa 1528Ala Ala Gly Glu Ser Val Glu 470475<210>542<211>476<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>542Met Cys Glu Arg Pro Glu Lys Tyr Val Thr Asp Phe Ser Leu Tyr Leu 151015 Val Thr Asp Pro Val Leu Gly Gly Gly Pro Lys Lys Val Ala Gly Ile

20 25 30Val Asp Ser Ala Ile Ser Gly Gly Val Ser Val Val Gln Leu Arg Asp

35 40 45Lys Asn Ser Gly Val Glu Asp Val Arg Ala Ala Ala Lys Glu Leu Lys

50 55 60Glu Leu Cys Asp Ala Arg Gly Val Ala Leu Val Val Asn Asp Tyr Leu 65 70 75 80Asp Ile Ala Val Glu Leu Gly Leu His Leu His Ile Gly Gln Gly Asp

85 90 95Thr Pro Tyr Thr Gln Ala Arg Glu Leu Leu Pro Ala His Leu Glu Leu

100 105 110Gly Leu Ser Ile Glu Asn Leu Asp Gln Leu His Ala Val Ile Ala Gln

115 120 125Cys Ala Glu Thr Gly Val Ala Leu Pro Asp Val Ile Gly Ile Gly Pro

130 135 140Val Ala Ser Thr Ala Thr Lys Pro Asp Ala Ala Pro Ala Leu Gly Val145 150 155 160Glu Gly Ile Ala Glu Ile Ala Ala Val Ala Gln Asp His Gly Ile Ala

165 170 175Ser Val Ala Ile Gly Gly Val Gly Leu Arg Asn Ala Ala Glu Leu Ala

180 185 190Ala Thr Pro Ile Asp Gly Leu Cys Val Val Ser Glu Ile Met Thr Ala

195 200 205Ala Asn Pro Ala Ala Ala Ala Thr Arg Leu Arg Thr Ala Phe Gln Pro

210 215 220Thr Phe Ser Pro Glu Thr Gln Thr Glu Leu Ser Gln Thr Glu Leu Gln225 230 235 240Gly Ala Phe Val Asn Ser Pro Ser Ala Pro Arg Val Leu Ser Ile Ala

245 250 255Gly Thr Asp Pro Thr Gly Gly Ala Gly Ile Gln Ala Asp Leu Lys Ser

260 265 270Ile Ala Ala Gly Gly Gly Tyr Gly Met Cys Val Val Thr Ser Leu Val

275 280 285Ala Gln Asn Thr His Gly Val Asn Thr Ile His Thr Pro Pro Leu Thr

290 295 300Phe Leu Glu Glu Gln Leu Glu Ala Val Phe Ser Asp Val Thr Val Asp305 310 315 320Ala Ile Lys Leu Gly Met Leu Gly Ser Ala Asp Thr Val Asp Leu Val

325 330 335Ala Ser Trp Leu Gly Ser His Glu His Gly Pro Val Val Leu Asp Pro

340 345 350Val Met Ile Ala Thr Ser Gly Asp Arg Leu Leu Asp Ala Ser Ala Glu

355 360 365Glu Ser Leu Arg Arg Leu Ala Val His Val Asp Val Val Thr Pro Asn

370 375 380Ile Pro Glu Leu Ala Val Leu Cys Asp Ser Ala Pro Ala Ile Thr Met385 390 395 400Asp Glu Ala Ile Ala Gln Ala Gln Gly Phe Ala Arg Thr His Asp Thr

405 410 415Ile Val Ile Val Lys Gly Gly His Leu Thr Gly Ala Leu Ala Asp Asn

420 425 430Ala Val Val Arg Pro Asp Gly Ser Val Phe Gln Val Glu Asn Leu Arg

435 440 445Val Asn Thr Thr Asn Ser His Gly Thr Gly Cys Ser Leu Ser Ala Ser

450455460 Leu Ala Thr Lys Ile Ala Ala Gly Glu Ser Val Glu 465470475<210>543<211>723<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<700><223>RXN01413<400>543tttgccctat tggaagaagt aaattccaca ccttcacttt ccaatacttc ttttggtgag 60cgggtttcct cagcgtttaa ccatctgaaa ccatctgaga ttg acc cat ctg ttc 115

Leu Thr His Leu Phe

1 5tta gaa ctc gat gag cgt tta gta ctg ggt gtt cag caa gat ggt tac 163Leu Glu Leu Asp Glu Arg Leu Val Leu Gly Val Gln Gln Asp Gly Tyr

10 15 20caa tgg act gag cat ttg ttc cgg ctg cca ctg caa cat ctc cgt aac 211Gln Trp Thr Glu His Leu Phe Arg Leu Pro Leu Gln His Leu Arg Asn

25 30 35tcg ccc aat gac ctg cag gga ttg aag ata cga tgg tgt gaa ctt tat 259Ser Pro Asn Asp Leu Gln Gly Leu Lys Ile Arg Trp Cys Glu Leu Tyr

40 45 50tcc aca acg ggg aaa gat caa ggg gta gaa ctt ctg cct caa gca acc 307Ser Thr Thr Gly Lys Asp Gln Gly Val Glu Leu Leu Pro Gln Ala Thr

55 60 65gtc gtt acc ccaaat aac ttc gag gct tcc acc ctc tcc ggc ctt gag 355Val Val Thr Pro Asn Asn Phe Glu Ala Ser Thr Leu Ser Gly Leu Glu 70 75 80 85aag ctt gag acc gtc gag gac ctc aag gag gct gcc cgc ctc att tat 403Lys Leu Glu Thr Val Glu Asp Leu Lys Glu Ala Ala Arg Leu Ile Tyr

90 95 100gag caa ggc ccc cag tac gta gtc gtc aag ggt ggc atg gac ttc ccc 451Glu Gln Gly Pro Gln Tyr Val Val Val Lys Gly Gly Met Asp Phe Pro

105 110 115ggc gag aac gcc gtg gat gtg ctt ttc gac gga tcc tcc tac cac gtc 499Gly Glu Asn Ala Val Asp Val Leu Phe Asp Gly Ser Ser Tyr His Val

120 125 130ttc tct gag cca aag att ggt gaa gag cgc gtt tcc ggc gca gtc tgc 547Phe Ser Glu Pro Lys Ile Gly Glu Glu Arg Val Ser Gly Ala Val Cys

135 140 145acc ttc gca gct gtt atc acc gca gag cta gca aag ggt gct gag gtt 595Thr Phe Ala Ala Val Ile Thr Ala Glu Leu Ala Lys Gly Ala Glu Val150 155 160 165gta gac cca gtg gca acc gca aag cgt gtg gtc acc cgt gcg gtt caa 643Val Asp Pro Val Ala Thr Ala Lys Arg Val Val Thr Arg Ala Val Gln

170 175 180gat gct gtt gca tcc aac gca cct ttt acc tcc gta tgg ctt gct gag 691Asp Ala Val Ala Ser Asn Ala Pro Phe Thr Ser Val Trp Leu Ala Glu

185 190 195gac aac aag tagagtttta aaataccgat caa 723Asp Asn Lys

200<210>544<211>200<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>544Leu Thr His Leu Phe Leu Glu Leu Asp Glu Arg Leu Val Leu Gly Val 151015 Gln Gln Asp Gly Tyr Gln Trp Thr Glu His Leu Phe Arg Leu Pro Leu

20 25 30Gln His Leu Arg Asn Ser Pro Asn Asp Leu Gln Gly Leu Lys Ile Arg

35 40 45Trp Cys Glu Leu Tyr Ser Thr Thr Gly Lys Asp Gln Gly Val Glu Leu

50 55 60Leu Pro Gln Ala Thr Val Val Thr Pro Asn Asn Phe Glu Ala Ser Thr 65 70 75 80Leu Ser Gly Leu Glu Lys Leu Glu Thr Val Glu Asp Leu Lys Glu Ala

85 90 95Ala Arg Leu Ile Tyr Glu Gln Gly Pro Gln Tyr Val Val Val Lys Gly

100 105 110Gly Met Asp Phe Pro Gly Glu Asn Ala Val Asp Val Leu Phe Asp Gly

115 120 125Ser Ser Tyr His Val Phe Ser Glu Pro Lys Ile Gly Glu Glu Arg Val

130 135 140Ser Gly Ala Val Cys Thr Phe Ala Ala Val Ile Thr Ala Glu Leu Ala145 150 155 160Lys Gly Ala Glu Val Val Asp Pro Val Ala Thr Ala Lys Arg Val Val

165 170 175Thr Arg Ala Val Gln Asp Ala Val Ala Ser Asn Ala Pro Phe Thr Ser

180 185 190Val Trp Leu Ala Glu Asp Asn Lys

195200<210>545<211>795<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<772)<223>RXN01617<400>545tcagaagcta ccggcggcgc cggcatccag gttgatttga agaccttcca gcatttaaga 60tgtttatggc attgggtcca tcacatgctt gggtggcctt ttg atc cta aag aca 115

Leu Ile Leu Lys Thr

1 5act gga atc acc gtt ttg tcc cgg ttt gat gcg cag gtt atc gct aat 163Thr Gly Ile Thr Val Leu Ser Arg Phe Asp Ala Gln Val Ile Ala Asn

10 15 20cag att gag gcc gcc acc gca gcg cac gat ctt gat gtg gtg aag atc 211Gln Ile Glu Ala Ala Thr Ala Ala His Asp Leu Asp Val Val Lys Ile

25 30 35ggt atg ttg ggt act cct gca acg atc gat act gtg gca acc gct ttg 259Gly Met Leu Gly Thr Pro Ala Thr Ile Asp Thr Val Ala Thr Ala Leu

40 45 50gag gaa aac agc ttc aag cac gtt gtc cta gac ccg gta ctg atc tgc 307Glu Glu Asn Ser Phe Lys His Val Val Leu Asp Pro Val Leu Ile Cys

55 60 65aag ggc cag gag ccc ggc gcg gca ctt gat act gac act gcc ctt cgc 355Lys Gly Gln Glu Pro Gly Ala Ala Leu Asp Thr Asp Thr Ala Leu Arg 70 75 80 85gcg aag gtg ctg cca cag gca acc gtg gtt act cca aac aac ttc gag 403Ala Lys Val Leu Pro Gln Ala Thr Val Val Thr Pro Asn Asn Phe Glu

90 95 100gcc acc acc ctg tct ggc cta gac aag ctg gag acc atc gac gac ctg 451Ala Thr Thr Leu Ser Gly Leu Asp Lys Leu Glu Thr Ile Asp Asp Leu

105 110 115aag gaa gca gcc cgc ctc att cat gag caa gga cct cag tac gtc gtt 499Lys Glu Ala Ala Arg Leu Ile His Glu Gln Gly Pro Gln Tyr Val Val

120 125 130gtt aag ggt ggc atc gac ttc cca ggc gac aac gct gtg gac gta ctt 547Val Lys Gly Gly Ile Asp Phe Pro Gly Asp Asn Ala Val Asp Val Leu

135 140 145ttc gac ggc acc gac tac cac gtg ttc tct gaa cca aag atc ggc gac 595Phe Asp Gly Thr Asp Tyr His Val Phe Ser Glu Pro Lys Ile Gly Asp150 155 160 165gag cgc gtc tcc ggc gct ggc tgt acc ttc gca gct gtc atc acc gca 643Glu Arg Val Ser Gly Ala Gly Cys Thr Phe Ala Ala Val Ile Thr Ala

170 175 180gag ctg gcc aag ggc aac tct gcc gtt gat gca gtg acc acc gct aag 691Glu Leu Ala Lys Gly Asn Ser Ala Val Asp Ala Val Thr Thr Ala Lys

185 190 195cgc gta gtc acc cgc gca gtg aag gac gct gtc gca tcc aac gca ccg 739Arg Val Val Thr Arg Ala Val Lys Asp Ala Val Ala Ser Asn Ala Pro

200 205 210ttt acc tct gtg tgg ttg gcg gaa gac aac aag tagaaatctt aaacaagctc 792Phe Thr Ser Val Trp Leu Ala Glu Asp Asn Lys

215220 cct 795<210>546<211>224<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>546Leu Ile Leu Lys Thr Thr Gly Ile Thr Val Leu Ser Arg Phe Asp Ala 151015 Gln Val Ile Ala Asn Gln Ile Glu Ala Ala Thr Ala Ala His Asp Leu

20 25 30Asp Val Val Lys Ile Gly Met Leu Gly Thr Pro Ala Thr Ile Asp Thr

35 40 45Val Ala Thr Ala Leu Glu Glu Asn Ser Phe Lys His Val Val Leu Asp

50 55 60Pro Val Leu Ile Cys Lys Gly Gln Glu Pro Gly Ala Ala Leu Asp Thr 65 70 75 80Asp Thr Ala Leu Arg Ala Lys Val Leu Pro Gln Ala Thr Val Val Thr

85 90 95Pro Asn Asn Phe Glu Ala Thr Thr Leu Ser Gly Leu Asp Lys Leu Glu

100 105 110Thr Ile Asp Asp Leu Lys Glu Ala Ala Arg Leu Ile His Glu Gln Gly

115 120 125Pro Gln Tyr Val Val Val Lys Gly Gly Ile Asp Phe Pro Gly Asp Asn

130 135 140Ala Val Asp Val Leu Phe Asp Gly Thr Asp Tyr His Val Phe Ser Glu145 150 155 160Pro Lys Ile Gly Asp Glu Arg Val Ser Gly Ala Gly Cys Thr Phe Ala

165 170 175Ala Val Ile Thr Ala Glu Leu Ala Lys Gly Asn Ser Ala Val Asp Ala

180 185 190Val Thr Thr Ala Lys Arg Val Val Thr Arg Ala Val Lys Asp Ala Val

195 200 205Ala Ser Asn Ala Pro Phe Thr Ser Val Trp Leu Ala Glu Asp Asn Lys

210215220<210>547<211>638<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (615)<223>FRXA01617<400>547gct aat cag att gag gcc gcc acc gca gcg cac gat ctt gat gtg gtg 48Ala Asn Gln Ile Glu Ala Ala Thr Ala Ala His Asp Leu Asp Val Val 151015 aag atc ggt atg ttg ggt act cct gca acg atc gat act gtg gca acc 96Lys Ile Gly Met Leu Gly Thr Pro Ala Thr Ile Asp Thr Val Ala Thr

20 25 30gct ttg gag gaa aac agc ttc aag cac gtt gtc cta gac ccg gta ctg 144Ala Leu Glu Glu Asn Ser Phe Lys His Val Val Leu Asp Pro Val Leu

35 40 45atc tgc aag ggc cag gag ccc ggc gcg gca ctt gat act gac act gcc 192Ile Cys Lys Gly Gln Glu Pro Gly Ala Ala Leu Asp Thr Asp Thr Ala

50 55 60ctt cgc gcg aag gtg ctg cca cag gca acc gtg gtt act cca aac aac 240Leu Arg Ala Lys Val Leu Pro Gln Ala Thr Val Val Thr Pro Asn Asn 65 70 75 80ttc gag gcc acc acc ctg tct ggc cta gac aag ctg gag acc atc gac 288Phe Glu Ala Thr Thr Leu Ser Gly Leu Asp Lys Leu Glu Thr Ile Asp

85 90 95gac ctg aag gaa gca gcc cgc ctc att cat gag caa gga cct cag tac 336Asp Leu Lys Glu Ala Ala Arg Leu Ile His Glu Gln Gly Pro Gln Tyr

100 105 110gtc gtt gtt aag ggt ggc atc gac ttc cca ggc gac aac gct gtg gac 384Val Val Val Lys Gly Gly Ile Asp Phe Pro Gly Asp Asn Ala Val Asp

115 120 125gta ctt ttc gac ggc acc gac tac cac gtg ttc tct gaa cca aag atc 432Val Leu Phe Asp Gly Thr Asp Tyr His Val Phe Ser Glu Pro Lys Ile

130 135 140ggc gac gag cgc gtc tcc ggc gct ggc tgt acc ttc gca gct gtc atc 480Gly Asp Glu Arg Val Ser Gly Ala Gly Cys Thr Phe Ala Ala Val Ile145 150 155 160acc gca gag ctg gcc aag ggc aac tct gcc gtt gat gca gtg acc acc 528Thr Ala Glu Leu Ala Lys GIy Asn Ser Ala Val Asp Ala Val Thr Thr

165 170 175gct aag cgc gta gtc acc cgc gca gtg aag gac gct gtc gca tcc aac 576Ala Lys Arg Val Val Thr Arg Ala Val Lys Asp Ala Val Ala Ser Asn

180 185 190gca ccg ttt acc tct gtg tgg ttg gcg gaa gac aac aag tagaaatctt 625Ala Pro Phe Thr Ser Val Trp Leu Ala Glu Asp Asn Lys

195200205 aaacaagctc cct 638<210>548<211>205<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>548Ala Asn Gln Ile Glu Ala Ala Thr Ala Ala His Asp Leu Asp Val Val 151015 Lys Ile Gly Met Leu Gly Thr Pro Ala Thr Ile Asp Thr Val Ala Thr

20 25 30Ala Leu Glu Glu Asn Ser Phe Lys His Val Val Leu Asp Pro Val Leu

35 40 45Ile Cys Lys Gly Gln Glu Pro Gly Ala Ala Leu Asp Thr Asp Thr Ala

50 55 60Leu Arg Ala Lys Val Leu Pro Gln Ala Thr Val Val Thr Pro Asn Asn 65 70 75 80Phe Glu Ala Thr Thr Leu Ser Gly Leu Asp Lys Leu Glu Thr Ile Asp

85 90 95Asp Leu Lys Glu Ala Ala Arg Leu Ile His Glu Gln Gly Pro Gln Tyr

100 105 110Val Val Val Lys Gly Gly Ile Asp Phe Pro Gly Asp Asn Ala Val Asp

115 120 125Val Leu Phe Asp Gly Thr Asp Tyr His Val Phe Ser Glu Pro Lys Ile

130 135 140Gly Asp Glu Arg Val Ser Gly Ala Gly Cys Thr Phe Ala Ala Val Ile145 150 155 160Thr Ala Glu Leu Ala Lys Gly Asn Ser Ala Val Asp Ala Val Thr Thr

165 170 175Ala Lys Arg Val Val Thr Arg Ala Val Lys Asp Ala Val Ala Ser Asn

180 185 190Ala Pro Phe Thr Ser Val Trp Leu Ala Glu Asp Asn Lys

195200205<210>549<211>915<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (892)<223>RXS01807<400>549gctcaccgag ctggacacca agctccgcgc agtgcaggaa gaacacggcg agctggaaat 60gcagtggctg gaactcggcg aggaaatcga gggctagttc atg ccg tcg gca ggc 115

Met Pro Ser Ala Gly

1 5gag gag att tta gag cag cgc gca cag ctg gag ttt gat cag cgc cgc 163Glu Glu Ile Leu Glu Gln Arg Ala Gln Leu Glu Phe Asp Gln Arg Arg

10 15 20gcc gat gtg gtg atg atc ggc agc cag gtg gtt tat ggt tcc gtg ggg 211Ala Asp Val Val Met Ile Gly Ser Gln Val Val Tyr Gly Ser Val Gly

25 30 35ctc agt gct gcc att ccg gtg atg cac aac gaa ggc ctc cgc gtg gtc 259Leu Ser Ala Ala Ile Pro Val Met His Asn Glu Gly Leu Arg Val Val

40 45 50gct gtc ccc acc gtg gtg tta agt tcc atg ccg cgt tat gca agt tct 307Ala Val Pro Thr Val Val Leu Ser Ser Met Pro Arg Tyr Ala Ser Ser

55 60 65cac cgc cag ccg atg tcg gac caa tgg ctc gcc gac gcg ctg caa gac 355His Arg Gln Pro Met Ser Asp Gln Trp Leu Ala Asp Ala Leu Gln Asp 70 75 80 85ctg gtg gat ctg ggg att atc gat gag gtt tcc acc att tcc acc ggc 403Leu Val Asp Leu Gly Ile Ile Asp Glu Val Ser Thr Ile Ser Thr Gly

90 95 100tat ttt acc tcc gct tct cag gtg cgt gtg gtc gct gcg tgg ctg cag 451Tyr Phe Thr Ser Ala Ser Gln Val Arg Val Val Ala Ala Trp Leu Gln

105 110 115aaa atc cgc gaa acc cat ccg cat gtg cgc atc gtg gtg gat ccc atc 499Lys Ile Arg Glu Thr His Pro His Val Arg Ile Val Val Asp Pro Ile

120 125 130atg ggg gac agt gac gtg gga att tat gtc gcc gac gag atc gca acc 547Met Gly Asp Ser Asp Val Gly Ile Tyr Val Ala Asp Glu Ile Ala Thr

135 140 145gcc atc tgc cag gac tta tgc cct ctg gct acc gga atc att ccc aat 595Ala Ile Cys Gln Asp Leu Cys Pro Leu Ala Thr Gly Ile Ile Pro Asn150 155 160 165gct ttc gag ctc tcc cac atg gtt ggc tcc ggc gat ccg cgc tcg ctg 643Ala Phe Glu Leu Ser His Met Val Gly Ser Gly Asp Pro Arg Ser Leu

170 175 180ctc ggc ccg ttt ggc gag tgg atc atc atc acc agc gcc act gaa act 691Leu Gly Pro Phe Gly Glu Trp Ile Ile Ile Thr Ser Ala Thr Glu Thr

185 190 195gtg ggc acc acc gtc acc cgc atc gtc acc cgt gac agc gtc cag gaa 739Val Gly Thr Thr Val Thr Arg Ile Val Thr Arg Asp Ser Val Gln Glu

200 205 210atc gcc tcc gcc acc gtc gat acc acg gcc aaa ggg gca ggc gac gtc 787Ile Ala Ser Ala Thr Val Asp Thr Thr Ala Lys Gly Ala Gly Asp Val

215 220 225tac gcc gca gca tta atc gcc gcc ctg cat aaa gat ttt tcg ctt atc 835Tyr Ala Ala Ala Leu Ile Ala Ala Leu His Lys Asp Phe Ser Leu Ile230 235 240 245gac gcc gcc agc cac gca tcc aac acc gtc tgc gcc ggc ctg cag acc 883Asp Ala Ala Ser His Ala Ser Asn Thr Val Cys Ala Gly Leu Gln Thr

250255260 aaa gcg ctt taggtttcgt ccgtctctga cag 915Lys Ala Leu<210>550<211>264<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>550Met Pro Ser Ala Gly Glu Glu Ile Leu Glu Gln Arg Ala Gln Leu Glu 151015 Phe Asp Gln Arg Arg Ala Asp Val Val Met Ile Gly Ser Gln Val Val

20 25 30Tyr Gly Ser Val Gly Leu Ser Ala Ala Ile Pro Val Met His Asn Glu

35 40 45Gly Leu Arg Val Val Ala Val Pro Thr Val Val Leu Ser Ser Met Pro

50 55 60Arg Tyr Ala Ser Ser His Arg Gln Pro Met Ser Asp Gln Trp Leu Ala 65 70 75 80Asp Ala Leu Gln Asp Leu Val Asp Leu Gly Ile Ile Asp Glu Val Ser

85 90 95Thr Ile Ser Thr Gly Tyr Phe Thr Ser Ala Ser Gln Val Arg Val Val

100 105 110Ala Ala Trp Leu Gln Lys Ile Arg Glu Thr His Pro His Val Arg Ile

115 120 125Val Val Asp Pro Ile Met Gly Asp Ser Asp Val Gly Ile Tyr Val Ala

130 135 140Asp Glu Ile Ala Thr Ala Ile Cys Gln Asp Leu Cys Pro Leu Ala Thr145 150 155 160Gly Ile Ile Pro Asn Ala Phe Glu Leu Ser His Met Val Gly Ser Gly

165 170 175Asp Pro Arg Ser Leu Leu Gly Pro Phe Gly Glu Trp Ile Ile Ile Thr

180 185 190Ser Ala Thr Glu Thr Val Gly Thr Thr Val Thr Arg Ile Val Thr Arg

195 200 205Asp Ser Val Gln Glu Ile Ala Ser Ala Thr Val Asp Thr Thr Ala Lys

210 215 220Gly Ala Gly Asp Val Tyr Ala Ala Ala Leu Ile Ala Ala Leu His Lys225230 235 240Asp Phe Ser Leu Ile Asp Ala Ala Ser His Ala Ser Asn Thr Val Cys

245 250 255Ala Gly Leu Gln Thr Lys Ala Leu

260

<210>551<211>622<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (622)<223>RXC01021<400>551cgagaggctt ttttggctct aagcctttta gtcgtgcgaa cgaaatctta agcagcctcg 60gtgccaccga gatcgattgg tcgctgtaag gtatctgatt atg tcc agt tcc gaa 115

Met Ser Ser Ser Glu

1 5agc tcg cgt tcc gaa ggc tcg cag cca gca ccg tct gta cag cct gaa 163Ser Ser Arg Ser Glu Gly Ser Gln Pro Ala Pro Ser Val Gln Pro Glu

10 15 20cgc cgt gct gat tca acg ggg gct cct gcg gca gct tcc aag gaa gct 211Arg Arg Ala Asp Ser Thr Gly Ala Pro Ala Ala Ala Ser Lys Glu Ala

25 30 35tcc caa caa atg gac gct gcc gga gtt ctt gag tgg gcc agg acc gct 259Ser Gln Gln Met Asp Ala Ala Gly Val Leu Glu Trp Ala Arg Thr Ala

40 45 50gtc gag cag ctt tct gaa cgt cgt gca gag atc aat gca ctg aat gtc 307Val Glu Gln Leu Ser Glu Arg Arg Ala Glu Ile Asn Ala Leu Asn Val

55 60 65ttt cct gtt cca gat gca gac act gga tca aac atg acc tac acc atg 355Phe Pro Val Pro Asp Ala Asp Thr Gly Ser Asn Met Thr Tyr Thr Met 70 75 80 85aca gct gcg ttg gat gaa gcg ctg aaa ctg ggg gag ttg ggt gat gtc 403Thr Ala Ala Leu Asp Glu Ala Leu Lys Leu Gly Glu Leu Gly Asp Val

90 95 100gca agg att act gag gct ttg gct gtt ggt tct gtg cgt gga gcc cga 451Ala Arg Ile Thr Glu Ala Leu Ala Val Gly Ser Val Arg Gly Ala Arg

105 110 115gga aat tct gga gta gtc ctt agt cag gtc ctt cgc gct att gct cag 499Gly Asn Ser Gly Val Val Leu Ser Gln Val Leu Arg Ala Ile Ala Gln

120 125 130gca gct gct gac ggg gtt att gat ggc cac aca atc caa gaa gcg cta 547Ala Ala Ala Asp Gly Val Ile Asp Gly His Thr Ile Gln Glu Ala Leu

135 140 145tcc att gct cgc tcc cta gtt gat cgc gca att aca gat cct gtg gag 595Ser Ile Ala Arg Ser Leu Val Asp Arg Ala Ile Thr Asp Pro Val Glu150 155 160 165ggc act gtt gtc act gtg ttg cgt tct 622Gly Thr Val Val Thr Val Leu Arg Ser

170<210>552<211>174<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>552Met Ser Ser Ser Glu Ser Ser Arg Ser Glu Gly Ser Gln Pro Ala Pro 151015 Ser Val Gln Pro Glu Arg Arg Ala Asp Ser Thr Gly Ala Pro Ala Ala

20 25 30Ala Ser Lys Glu Ala Ser Gln Gln Met Asp Ala Ala Gly Val Leu Glu

35 40 45Trp Ala Arg Thr Ala Val Glu Gln Leu Ser Glu Arg Arg Ala Glu Ile

50 55 60Asn Ala Leu Asn Val Phe Pro Val Pro Asp Ala Asp Thr Gly Ser Asn 65 70 75 80Met Thr Tyr Thr Met Thr Ala Ala Leu Asp Glu Ala Leu Lys Leu Gly

8590 95Glu Leu Gly Asp Val Ala Arg Ile Thr Glu Ala Leu Ala Val Gly Ser

100 105 110Val Arg Gly Ala Arg Gly Asn Ser Gly Val Val Leu Ser Gln Val Leu

115 120 125Arg Ala Ile Ala Gln Ala Ala Ala Asp Gly Val Ile Asp Gly His Thr

130 135 140Ile Gln Glu Ala Leu Ser Ile Ala Arg Ser Leu Val Asp Arg Ala Ile145 150 155 160Thr Asp Pro Val Glu Gly Thr Val Val Thr Val Leu Arg Ser

165170<210>553<211>1107<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1084)<223>RXN02246<400>553tgccgacgct ggcgtggatg ccttcgttgc aggttccgct gtgtacggcg ctgaggatcc 60caacaaggcg atccaggagt tgcgagcact cgcgcagtaa atg gat gtt gcg cac 115

Met Asp Val Ala His

1 5gcg tta gat ctg gcc cac cac gtg tca gat caa gtc cga ggc acc acc 163Ala Leu Asp Leu Ala His His Val Ser Asp Gln Val Arg Gly Thr Thr

10 15 20agc cct aat ccg cca gtc ggc gct gtc att ttg gac gcc gac ggc gag 211Ser Pro Asn Pro Pro Val Gly Ala Val Ile Leu Asp Ala Asp Gly Glu

25 30 35gtc gtt ggc gtt ggc gcc acg gca cct cct ggt ggc ccg cac gcc gaa 259Val Val Gly Val Gly Ala Thr Ala Pro Pro Gly Gly Pro His Ala Glu

40 45 50gtg gtg gcg ctt gca gct gcc gga gtg cgt gcc aac ggg ggc acg gcg 307Val Val Ala Leu Ala Ala Ala Gly Val Arg Ala Asn Gly Gly Thr Ala

55 60 65gtg gtc acc ctc gag ccg tgc aac cat tac ggc cgc acg ggt cca tgt 355Val Val Thr Leu Glu Pro Cys Asn His Tyr Gly Arg Thr Gly Pro Cys 70 75 80 85tcc aag gcg ctt ctc gac gcc ggg atc gca cac gtg ttt tac gcc aat 403Ser Lys Ala Leu Leu Asp Ala Gly Ile Ala His Val Phe Tyr Ala Asn

90 95 100gcg gat ccc ttc ccg tca gcc gct ggg ggc ggt gcc ttt ttg gcg gag 451Ala Asp Pro Phe Pro Ser Ala Ala Gly Gly Gly Ala Phe Leu Ala Glu

105 110 115gcg ggc gtc gat acg cat ttt tta gat gag cgg atc agg gca ctg gag 499Ala Gly Val Asp Thr His Phe Leu Asp Glu Arg Ile Arg Ala Leu Glu

120 125 130ccc tgg ctg gtt gcg acg cgt ctg ggc agg ccc cat gtc acg ttg aag 547Pro Trp Leu Val Ala Thr Arg Leu Gly Arg Pro His Val Thr Leu Lys

135 140 145ttt gcg tcc acc gtg gac ggt ttt gct ggt gcc acc gat ggc acc agc 595Phe Ala Ser Thr Val Asp Gly Phe Ala Gly Ala Thr Asp Gly Thr Ser150 155 160 165cag tgg att acc ggg ccg gat gcg cgg gcg ttt gtg cac gaa gat cga 643Gln Trp Ile Thr Gly Pro Asp Ala Arg Ala Phe Val His Glu Asp Arg

170 175 180agt aaa aga gat gcg atc atc gtg ggt acc ggt act gcg ttg act gat 691Ser Lys Arg Asp Ala Ile Ile Val Gly Thr Gly Thr Ala Leu Thr Asp

185 190 195aat ccc tcc ttg acg gcg cgg acc gat acg ggt ctt tat gaa aat caa 739Asn Pro Ser Leu Thr Ala Arg Thr Asp Thr Gly Leu Tyr Glu Asn Gln

200 205 210ccc agg cgc gtt gtt att ggc tcc cgc gag gtt cca gca gat tcc aac 787Pro Arg Arg Val Val Ile Gly Ser Arg Glu Val Pro Ala Asp Ser Asn

215 220 225ttg gct cgc ttg gga tat gag cag tac gcg gga ata cca gag gct tta 835Leu Ala Arg Leu Gly Tyr Glu Gln Tyr Ala Gly Ile Pro Glu Ala Leu230 235 240 245tca gcg ctg tgg gat aaa ggg tgc cga gac att tta atc gaa ggt ggc 883Ser Ala Leu Trp Asp Lys Gly Cys Arg Asp Ile Leu Ile Glu Gly Gly

250 255 260cca acg tta gct ggg gca gcg ctg cgc tta ggc att gtt gat cag gtg 931Pro Thr Leu Ala Gly Ala Ala Leu Arg Leu Gly Ile Val Asp Gln Val

265 270 275cag gcc tat gtt gcc ccc gct ttg ttg ggc gct gga cga tca gtg att 979Gln Ala Tyr Val Ala Pro Ala Leu Leu Gly Ala Gly Arg Ser Val Ile

280 285 290aac tgg cca caa gaa acc acg atg gat cag att atg cgt ttt gac acc 1027Asn Trp Pro Gln Glu Thr Thr Met Asp Gln Ile Met Arg Phe Asp Thr

295300305 acg tcc gtg aga cag ttg ggt tca gat gta ttg ata gaa atg atg aga 1075Thr Ser Val Arg Gln Leu Gly Ser Asp Val Leu Ile Glu Met Met Arg 310315320325 aag gaa cac taaatgttca caggtattgt cga 1107Lys Glu His<210>554<211>328<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>554Met Asp Val Ala His Ala Leu Asp Leu Ala His His Val Ser Asp Gln 151015 Val Arg Gly Thr Thr Ser Pro Asn Pro Pro Val Gly Ala Val Ile Leu

20 25 30Asp Ala Asp Gly Glu Val Val Gly Val Gly Ala Thr Ala Pro Pro Gly

35 40 45Gly Pro His Ala Glu Val Val Ala Leu Ala Ala AlaGly Val Arg Ala

50 55 60Asn Gly Gly Thr Ala Val Val Thr Leu Glu Pro Cys Asn His Tyr Gly 65 70 75 80Arg Thr Gly Pro Cys Ser Lys Ala Leu Leu Asp Ala Gly Ile Ala His

85 90 95Val Phe Tyr Ala Asn Ala Asp Pro Phe Pro Ser Ala Ala Gly Gly Gly

100 105 110Ala Phe Leu Ala Glu Ala Gly Val Asp Thr His Phe Leu Asp Glu Arg

115 120 125Ile Arg Ala Leu Glu Pro Trp Leu Val Ala Thr Arg Leu Gly Arg Pro

130 135 140His Val Thr Leu Lys Phe Ala Ser Thr Val Asp Gly Phe Ala Gly Ala145 150 155 160Thr Asp Gly Thr Ser Gln Trp Ile Thr Gly Pro Asp Ala Arg Ala Phe

165 170 175Val His Glu Asp Arg Ser Lys Arg Asp Ala Ile Ile Val Gly Thr Gly

180 185 190Thr Ala Leu Thr Asp Asn Pro Ser Leu Thr Ala Arg Thr Asp Thr Gly

195 200 205Leu Tyr Glu Asn Gln Pro Arg Arg Val Val Ile Gly Ser Arg Glu Val

210 215 220Pro Ala Asp Ser Asn Leu Ala Arg Leu Gly Tyr Glu Gln Tyr Ala Gly225 230 235 240Ile Pro Glu Ala Leu Ser Ala Leu Trp Asp Lys Gly Cys Arg Asp Ile

245 250 255Leu Ile Glu Gly Gly Pro Thr Leu Ala Gly Ala Ala Leu Arg Leu Gly

260 265 270Ile Val Asp Gln Val Gln Ala Tyr Val Ala Pro Ala Leu Leu Gly Ala

275 280 285Gly Arg Ser Val Ile Asn Trp Pro Gln Glu Thr Thr Met Asp Gln Ile

290 295 300Met Arg Phe Asp Thr Thr Ser Val Arg Gln Leu Gly Ser Asp Val Leu305 310 315 320Ile Glu Met Met Arg Lys Glu His

325<210>555<211>1107<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1084)<223>FRXA02246<400>555tgccgacgct ggcgtggatg ccttcgttgc aggttccgct gtgtacggcg ctgaggatcc 60caacaaggcg atccaggagt tgcgagcact cgcgcagtaa atg gat gtt gcg cac 115

Met Asp Val Ala His

1 5gcg tta gat ctg gcc cac cac gtg tca gat caa gtc cga ggc acc acc 163Ala Leu Asp Leu Ala His His Val Ser Asp Gln Val Arg Gly Thr Thr

10 15 20agc cct aat ccg cca gtc ggc gct gtc att ttg gac gcc gac ggc gag 211Ser Pro Asn Pro Pro Val Gly Ala Val Ile Leu Asp Ala Asp Gly Glu

25 30 35gtc gtt ggc gtt ggc gcc acg gca cct cct ggt ggc ccg cac gcc gaa 259Val Val Gly Val Gly Ala Thr Ala Pro Pro Gly Gly Pro His Ala Glu

40 45 50gtg gtg gcg ctt gca gct gcc gga gtg cgt gcc aac ggg ggc acg gcg 307Val Val Ala Leu Ala Ala Ala Gly Val Arg Ala Asn Gly Gly Thr Ala

55 60 65gtg gtc acc ctc gag ccg tgc aac cat tac ggc cgc acg ggt cca tgt 355Val Val Thr Leu Glu Pro Cys Asn His Tyr Gly Arg Thr Gly Pro Cys 70 7580 85tcc aag gcg ctt ctc gac gcc ggg atc gca cac gtg ttt tac gcc aat 403Ser Lys Ala Leu Leu Asp Ala Gly Ile Ala His Val Phe Tyr Ala Asn

90 95 100gcg gat ccc ttc ccg tca gcc gct ggg ggc ggt gcc ttt ttg gcg gag 451Ala Asp Pro Phe Pro Ser Ala Ala Gly Gly Gly Ala Phe Leu Ala Glu

105 110 115gcg ggc gtc gat acg cat ttt tta gat gag cgg atc agg gca ctg gag 499Ala Gly Val Asp Thr His Phe Leu Asp Glu Arg Ile Arg Ala Leu Glu

120 125 130ccc tgg ctg gtt gcg acg cgt ctg ggc agg ccc cat gtc acg ttg aag 547Pro Trp Leu Val Ala Thr Arg Leu Gly Arg Pro His Val Thr Leu Lys

135 140 145ttt gcg tcc acc gtg gac ggt ttt gct ggt gcc acc gat ggc acc agc 595Phe Ala Ser Thr Val Asp Gly Phe Ala Gly Ala Thr Asp Gly Thr Ser150 155 160 165cag tgg att acc ggg ccg gat gcg cgg gcg ttt gtg cac gaa gat cga 643Gln Trp Ile Thr Gly Pro Asp Ala Arg Ala Phe Val His Glu Asp Arg

170 175 180agt aaa aga gat gcg atc atc gtg ggt acc ggt act gcg ttg act gat 691Ser Lys Arg Asp Ala Ile Ile Val Gly Thr Gly Thr Ala Leu Thr Asp

185 190 195aat ccc tcc ttg acg gcg cgg acc gat acg ggt ctt tat gaa aat caa 739Asn Pro Ser Leu Thr Ala Arg Thr Asp Thr Gly Leu Tyr Glu Asn Gln

200 205 210ccc agg cgc gtt gtt att ggc tcc cgc gag gtt cca gca gat tcc aac 787Pro Arg Arg Val Val Ile Gly Ser Arg Glu Val Pro Ala Asp Ser Asn

215 220 225ttg gct cgc ttg gga tat gag cag tac gcg gga ata cca gag gct tta 835Leu Ala Arg Leu Gly Tyr Glu Gln Tyr Ala Gly Ile Pro Glu Ala Leu230 235 240 245tca gcg ctg tgg gat aaa ggg tgc cga gac att tta atc gaa ggt ggc 883Ser Ala Leu Trp Asp Lys Gly Cys Arg Asp Ile Leu Ile Glu Gly Gly

250 255 260cca acg tta gct ggg gca gcg ctg cgc tta ggc att gtt gat cag gtg 931Pro Thr Leu Ala Gly Ala Ala Leu Arg Leu Gly Ile Val Asp Gln Val

265 270 275cag gcc tat gtt gcc ccc gct ttg ttg ggc gct gga cga tca gtg att 979Gln Ala Tyr Val Ala Pro Ala Leu Leu Gly Ala Gly Arg Ser Val Ile

280 285 290aac tgg cca caa gaa acc acg atg gat cag att atg cgt ttt gac acc 1027Asn Trp Pro Gln Glu Thr Thr Met Asp Gln Ile Met Arg Phe Asp Thr

295300305 acg tcc gtg aga cag ttg ggt tca gat gta ttg ata gaa atg atg aga 1075Thr Ser Val Arg Gln Leu Gly Ser Asp Val Leu Ile Glu Met Met Arg 310315320325 aag gaa cac taaatgttca caggtattgt cga 1107Lys Glu His<210>556<211>328<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>556Met Asp Val Ala His Ala Leu Asp Leu Ala His His Val Ser Asp Gln 151015 Val Arg Gly Thr Thr Ser Pro Asn Pro Pro Val Gly Ala Val Ile Leu

20 25 30Asp Ala Asp Gly Glu Val Val Gly Val Gly Ala Thr Ala Pro Pro Gly

35 40 45Gly Pro His Ala Glu Val Val Ala Leu Ala Ala Ala Gly Val Arg Ala

50 55 60Asn Gly Gly Thr Ala Val Val Thr Leu Glu Pro Cys Asn His Tyr Gly65 70 75 80Arg Thr Gly Pro Cys Ser Lys Ala Leu Leu Asp Ala Gly Ile Ala His

85 90 95Val Phe Tyr Ala Asn Ala Asp Pro Phe Pro Ser Ala Ala Gly Gly Gly

100 105 110Ala Phe Leu Ala Glu Ala Gly Val Asp Thr His Phe Leu Asp Glu Arg

115 120 125Ile Arg Ala Leu Glu Pro Trp Leu Val Ala Thr Arg Leu Gly Arg Pro

130 135 140His Val Thr Leu Lys Phe Ala Ser Thr Val Asp Gly Phe Ala Gly Ala145 150 155 160Thr Asp Gly Thr Ser Gln Trp Ile Thr Gly Pro Asp Ala Arg Ala Phe

165 170 175Val His Glu Asp Arg Ser Lys Arg Asp Ala Ile Ile Val Gly Thr Gly

180 185 190Thr Ala Leu Thr Asp Asn Pro Ser Leu Thr Ala Arg Thr Asp Thr Gly

195 200 205Leu Tyr Glu Asn Gln Pro Arg Arg Val Val Ile Gly Ser Arg Glu Val

210 215 220Pro Ala Asp Ser Asn Leu Ala Arg Leu Gly Tyr Glu Gln Tyr Ala Gly225 230 235 240lle Pro Glu Ala Leu Ser Ala Leu Trp Asp Lys Gly Cys Arg Asp Ile

245 250 255Leu Ile Glu Gly Gly Pro Thr Leu Ala Gly Ala Ala Leu Arg Leu Gly

260 265 270Ile Val Asp Gln Val Gln Ala Tyr Val Ala Pro Ala Leu Leu Gly Ala

275 280 285Gly Arg Ser Val Ile Asn Trp Pro Gln Glu Thr Thr Met Asp Gln Ile

290 295 300Met Arg Phe Asp Thr Thr Ser ValArg Gln Leu Gly Ser Asp Val Leu305 310 315 320Ile Glu Met Met Arg Lys Glu His

325<210>557<211>756<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (733)<223>RXA02247<400>557acaagaaacc acgatggatc agattatgcg ttttgacacc acgtccgtga gacagttggg 60ttcagatgta ttgatagaaa tgatgagaaa ggaacactaa atg ttc aca ggt att 115

Met Phe Thr Gly Ile

1 5gtc gag gag ctt ggc tcc gtt gca ggc gtg gaa cat ctg gga gat tcc 163Val Glu Glu Leu Gly Ser Val Ala Gly Val Glu His Leu Gly Asp Ser

10 15 20atc cgg atg cag att tcc gcg tcc acc gtt tta gag ggt gtg cat ttg 211Ile Arg Met Gln Ile Ser Ala Ser Thr Val Leu Glu Gly Val His Leu

25 30 35ggg gat tcc att tct gtc aat ggt gtg tgc ttg aca gtg gcg tcc ttt 259Gly Asp Ser Ile Ser Val Asn Gly Val Cys Leu Thr Val Ala Ser Phe

40 45 50ggc gag gga cat ttc act gca gac ctc atg cag gaa acc tta gat cgc 307Gly Glu Gly His Phe Thr Ala Asp Leu Met Gln Glu Thr Leu Asp Arg

55 60 65agc tcc ctg ggc gca tta tcc acc ggt agc aaa gtc aac crt gag cgc 355Ser Ser Leu Gly Ala Leu Ser Thr Gly Ser Lys Val Asn Leu Glu Arg 70 75 80 85gcc atg gca gcc gat ggc cgt ctg ggt gga cac atc atg caa ggc cat 403Ala Met Ala Ala Asp Gly Arg Leu Gly Gly His Ile Met Gln Gly His

90 95 100gtt gat gcc acc acc tcg ctg atcaag cgc acc agc tca gag aac tgg 451Val Asp Ala Thr Thr Ser Leu Ile Lys Arg Thr Ser Ser Glu Asn Trp

105 110 115gat gtt ctg cgt ttt gag ctg cca gct gat ttg gct cgc tat gtg gtg 499Asp Val Leu Arg Phe Glu Leu Pro Ala Asp Leu Ala Arg Tyr Val Val

120 125 130gaa aaa ggc tcc atc gca ctc aat ggc aca tcc ttg act gta tcg tct 547Glu Lys Gly Ser Ile Ala Leu Asn Gly Thr Ser Leu Thr Val Ser Ser

135 140 145ttg ggt gat gat tgg ttt gag gtt tcc ctg att ccc acc acc ttg cgc 595Leu Gly Asp Asp Trp Phe Glu Val Ser Leu Ile Pro Thr Thr Leu Arg150 155 160 165gac acc acc cac ggc gaa ctg gcg gta ggg gat atc gta aac att gag 643Asp Thr Thr His Gly Glu Leu Ala Val Gly Asp Ile Val Asn Ile Glu

170 175 180gtt gat gtg atc gct aag tac gtc gaa cgc atg atg acg cgc ggc gtg 691Val Asp Val Ile Ala Lys Tyr Val Glu Arg Met Met Thr Arg Gly Val

185 190 195gct gga aac act ccc aat gac tac acc gat ttc acg aga gac 733Ala Gly Asn Thr Pro Asn Asp Tyr Thr Asp Phe Thr Arg Asp

200205210 taggttagac aacgtgagtg aac 756<210>558<211>211<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>558Met Phe Thr Gly Ile Val Glu Glu Leu Gly Ser Val Ala Gly Val Glu 151015 His Leu Gly Asp Ser Ile Arg Met Gln Ile Ser Ala Ser Thr Val Leu

20 25 30Glu Gly Val His Leu Gly Asp Ser Ile Ser Val Asn Gly Val Cys Leu

35 40 45Thr Val Ala Ser Phe Gly Glu Gly His Phe Thr Ala Asp Leu Met Gln

50 55 60Glu Thr Leu Asp Arg Ser Ser Leu Gly Ala Leu Ser Thr Gly Ser Lys 65 70 75 80Val Asn Leu Glu Arg Ala Met Ala Ala Asp Gly Arg Leu Gly Gly His

85 90 95Ile Met Gln Gly His Val Asp Ala Thr Thr Ser Leu Ile Lys Arg Thr

100 105 110Ser Ser Glu Asn Trp Asp Val Leu Arg Phe Glu Leu Pro Ala Asp Leu

115 120 125Ala Arg Tyr Val Val Glu Lys Gly Ser Ile Ala Leu Asn Gly Thr Ser

130 135 140Leu Thr Val Ser Ser Leu Gly Asp Asp Trp Phe Glu Val Ser Leu Ile145 150 155 160Pro Thr Thr Leu Arg Asp Thr Thr His Gly Glu Leu Ala Val Gly Asp

165 170 175Ile Val Asn Ile Glu Val Asp Val Ile Ala Lys Tyr Val Glu Arg Met

180 185 190Met Thr Arg Gly Val Ala Gly Asn Thr Pro Asn Asp Tyr Thr Asp Phe

195 200 205Thr Arg Asp

210<210>559<211>1389<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1366)<223>RXN02248<400>559gatgtgatcg ctaagtacgt cgaacgcatg atgacgcgcg gcgtggctgg aaacactccc 60aatgactaca ccgatttcac gagagactag gttagacaac gtg agt gaa cat gag 115

Val Ser Glu His Glu

1 5cag gca cac agc caa tta gat tct gtt gaa gag gcc atcgct gac atc 163Gln Ala His Ser Gln Leu Asp Ser Val Glu Glu Ala Ile Ala Asp Ile

10 15 20gct gcg ggt aaa gcc gtc gtg gtg gta gat gat gaa gat cgt gaa aat 211Ala Ala Gly Lys Ala Val Val Val Val Asp Asp Glu Asp Arg Glu Asn

25 30 35gaa ggc gac atc atc ttt gcc gcc gaa tta gcc act cca gaa tta gtc 259Glu Gly Asp Ile Ile Phe Ala Ala Glu Leu Ala Thr Pro Glu Leu Val

40 45 50gct ttc atg gtg cgt tat tcc tcg gga tac atc tgt gcg cca tta acc 307Ala Phe Met Val Arg Tyr Ser Ser Gly Tyr Ile Cys Ala Pro Leu Thr

55 60 65gca aag gat gca gat cgt ctt gat ctg cct ccg atg acc gcg cac aat 355Ala Lys Asp Ala Asp Arg Leu Asp Leu Pro Pro Met Thr Ala His Asn 70 75 80 85cag gat gcc cgc ggc acc gct tac acc gtg acc gtt gat gcc aac acc 403Gln Asp Ala Arg Gly Thr Ala Tyr Thr Val Thr Val Asp Ala Asn Thr

90 95 100ggc acc aca ggc att tct gca aca gac cgc gcc cac act ttg cgc ttg 451Gly Thr Thr Gly Ile Ser Ala Thr Asp Arg Ala His Thr Leu Arg Leu

105 110 115ctt gct gat cca gaa gcc gac cgc acg gat ttc acc cgt ccc gga cac 499Leu Ala Asp Pro Glu Ala Asp Arg Thr Asp Phe Thr Arg Pro Gly His

120 125 130gtt gtg cca ctg cgt gct cgt gaa ggt ggc gtc ttg gtg cgc gct gga 547Val Val Pro Leu Arg Ala Arg Glu Gly Gly Val Leu Val Arg Ala Gly

135 140 145cac acc gaa gca gct gtc gat ttg gct cgc gct gca ggc ctg cgc cca 595His Thr Glu Ala Ala Val Asp Leu Ala Arg Ala Ala Gly Leu Arg Pro150 155 160 165gca ggt gtt atc tgc gaa gtg gtc agt gaa gag gac ccc acc ggc atg 643Ala Gly Val Ile Cys Glu Val Val Ser Glu Glu Asp Pro Thr Gly Met

170 175 180gct cgg gtt cct gag ctg cgc cgc ttc tgc gat gag cac gat ctg aag 691Ala Arg Val Pro Glu Leu Arg Arg Phe Cys Asp Glu His Asp Leu Lys

185 190 195ctg atc tct att gag cag ctc att gag tgg cgt cgc aag aat gaa att 739Leu Ile Ser Ile Glu Gln Leu Ile Glu Trp Arg Arg Lys Asn Glu Ile

200 205 210ttg gtg gag cgc cag gtg gaa act gtg ctg cct acc gat ttc ggc acg 787Leu Val Glu Arg Gln Val Glu Thr Val Leu Pro Thr Asp Phe Gly Thr

215 220 225ttc aag gct gtt ggt tac cgt tcc atc atc gat ggc acc gag ctt gtt 835Phe Lys Ala Val Gly Tyr Arg Ser Ile Ile Asp Gly Thr Glu Leu Val230 235 240 245gcc att gtt gcc ggc gac gtg gca tcc gac ggt ggc gaa aac gtc ctg 883Ala Ile Val Ala Gly Asp Val Ala Ser Asp Gly Gly Glu Asn Val Leu

250 255 260gtt cga gtc cac tct gag tgc ttg act ggt gat gtt ttt gga tcc cgg 931Val Arg Val His Ser Glu Cys Leu Thr Gly Asp Val Phe Gly Ser Arg

265 270 275cgc tgc gac tgt gga cag cag ctg cac gag tct ttg cgc ctg atc cag 979Arg Cys Asp Cys Gly Gln Gln Leu His Glu Ser Leu Arg Leu Ile Gln

280 285 290gaa gct ggt cgg gga gta gtg gtg tac atg cgt ggg cat gag gga cga 1027Glu Ala Gly Arg Gly Val Val Val Tyr Met Arg Gly His Glu Gly Arg

295 300 305ggc att ggt ctg ctc gcc aag cta cgc gcc tac caa ctc cag gat gaa 1075Gly Ile Gly Leu Leu Ala Lys Leu Arg Ala Tyr Gln Leu Gln Asp Glu310 315 320 325ggt gcc gac acc gtc gat gcc aac ctc gca ctt ggt ctt cca gcc gat 1123Gly Ala Asp Thr Val Asp Ala Asn Leu Ala Leu Gly Leu Pro Ala Asp

330 335 340gcc cgc gaa ttt ggc acc agc gcc cag att ctc tac gac ttg ggt gtg 1171Ala Arg Glu Phe Gly Thr Ser Ala Gln Ile Leu Tyr Asp Leu Gly Val

345 350 355cgc tcg ctc aac ttg atc agc aac aac cca gcc aag aag gtg gga ctt 1219Arg Ser Leu Asn Leu Ile Ser Asn Asn Pro Ala Lys Lys Val Gly Leu

360 365 370gaa ggc cac ggc att tcc att gcc agc cga acc ccc atc cct gtt gct 1267Glu Gly His Gly Ile Ser Ile Ala Ser Arg Thr Pro Ile Pro Val Ala

375 380 385gtt cat gaa gac aat gtt cga tac ctg aaa acc aag cgt gac cgc atg 1315Val His Glu Asp Asn Val Arg Tyr Leu Lys Thr Lys Arg Asp Arg Met390 395 400 405gga cat gac ctc cca gat gtc gca ctg tgg gaa caa gag cac cca gaa 1363Gly His Asp Leu Pro Asp Val Ala Leu Trp Glu Gln Glu His Pro Glu

410415420 aac taaggagcac aacaatggct aaa 1389Asn<210>560<211>422<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>560Val Ser Glu His Glu Gln Ala His Ser Gln Leu Asp Ser Val Glu Glu 151015 Ala Ile Ala Asp Ile Ala Ala Gly Lys Ala Val Val Val Val Asp Asp

20 25 30Glu Asp Arg Glu Asn Glu Gly Asp Ile Ile Phe Ala Ala Glu Leu Ala

35 40 45Thr Pro Glu Leu Val Ala Phe MetVal Arg Tyr Ser Ser Gly Tyr Ile

50 55 60Cys Ala Pro Leu Thr Ala Lys Asp Ala Asp Arg Leu Asp Leu Pro Pro 65 70 75 80Met Thr Ala His Asn Gln Asp Ala Arg Gly Thr Ala Tyr Thr Val Thr

85 90 95Val Asp Ala Asn Thr Gly Thr Thr Gly Ile Ser Ala Thr Asp Arg Ala

100 105 110His Thr Leu Arg Leu Leu Ala Asp Pro Glu Ala Asp Arg Thr Asp Phe

115 120 125Thr Arg Pro Gly His Val Val Pro Leu Arg Ala Arg Glu Gly Gly Val

130 135 140Leu Val Arg Ala Gly His Thr Glu Ala Ala Val Asp Leu Ala Arg Ala145 150 155 160Ala Gly Leu Arg Pro Ala Gly Val Ile Cys Glu Val Val Ser Glu Glu

165 170 175Asp Pro Thr Gly Met Ala Arg Val Pro Glu Leu Arg Arg Phe Cys Asp

180 185 190Glu His Asp Leu Lys Leu Ile Ser Ile Glu Gln Leu Ile Glu Trp Arg

195 200 205Arg Lys Asn Glu Ile Leu Val Glu Arg Gln Val Glu Thr Val Leu Pro

210 215 220Thr Asp Phe Gly Thr Phe Lys Ala Val Gly Tyr Arg Ser Ile Ile Asp225 230 235 240Gly Thr Glu Leu Val Ala Ile Val Ala Gly Asp Val Ala Ser Asp Gly

245 250 255Gly Glu Asn Val Leu Val Arg Val His Ser Glu Cys Leu Thr Gly Asp

260 265 270Val Phe Gly Ser Arg ArgCys Asp Cys Gly Gln Gln Leu His Glu Ser

275 280 285Leu Arg Leu Ile Gln Glu Ala Gly Arg Gly Val Val Val Tyr Met Arg

290 295 300Gly His Glu Gly Arg Gly Ile Gly Leu Leu Ala Lys Leu Arg Ala Tyr305 310 315 320Gln Leu Gln Asp Glu Gly Ala Asp Thr Val Asp Ala Asn Leu Ala Leu

325 330 335Gly Leu Pro Ala Asp Ala Arg Glu Phe Gly Thr Ser Ala Gln Ile Leu

340 345 350Tyr Asp Leu Gly Val Arg Ser Leu Asn Leu Ile Ser Asn Asn Pro Ala

355 360 365Lys Lys Val Gly Leu Glu Gly His Gly Ile Ser Ile Ala Ser Arg Thr

370 375 380Pro Ile Pro Val Ala Val His Glu Asp Asn Val Arg Tyr Leu Lys Thr385 390 395 400Lys Arg Asp Arg Met Gly His Asp Leu Pro Asp Val Ala Leu Trp Glu

405 410 415Gln Glu His Pro Glu Asn

420<210>561<211>1389<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1366)<223>FRXA02248<400>561gatgtgatcg ctaagtacgt cgaacgcatg atgacgcgcg gcgtggctgg aaacactccc 60aatgactaca ccgatttcac gagagactag gttagacaac gtg agt gaa cat gag 115

Val Ser Glu His Glu

1 5cag gca cac agc caa tta gat tct gtt gaa gag gcc atc gct gac atc 163Gln Ala His Ser Gln Leu Asp Ser Val Glu Glu Ala Ile Ala Asp Ile

10 15 20gct gcg ggt aaa gcc gtc gtg gtg gta gat gat gaa gat cgt gaa aat 211Ala Ala Gly Lys Ala Val Val Val Val Asp Asp Glu Asp Arg Glu Asn

25 30 35gaa ggc gac atc atc ttt gcc gcc gaa tta gcc act cca gaa tta gtc 259Glu Gly Asp Ile Ile Phe Ala Ala Glu Leu Ala Thr Pro Glu Leu Val

40 45 50gct ttc atg gtg cgt tat tcc tcg gga tac atc tgt gcg cca tta acc 307Ala Phe Met Val Arg Tyr Ser Ser Gly Tyr Ile Cys Ala Pro Leu Thr

55 60 65gca aag gat gca gat cgt ctt gat ctg cct ccg atg acc gcg cac aat 355Ala Lys Asp Ala Asp Arg Leu Asp Leu Pro Pro Met Thr Ala His Asn 70 75 80 85cag gat gcc cgc ggc acc gct tac acc gtg acc gtt gat gcc aac acc 403Gln Asp Ala Arg Gly Thr Ala Tyr Thr Val Thr Val Asp Ala Asn Thr

90 95 100ggc acc aca ggc att tct gca aca gac cgc gcc cac act ttg cgc ttg 451Gly Thr Thr Gly Ile Ser Ala Thr Asp Arg Ala His Thr Leu Arg Leu

105 110 115ctt gct gat cca gaa gcc gac cgc acg gat ttc acc cgt ccc gga cac 499Leu Ala Asp Pro Glu Ala Asp Arg Thr Asp Phe Thr Arg Pro Gly His

120 125 130gtt gtg cca ctg cgt gct cgt gaa ggt ggc gtc ttg gtg cgc gct gga 547Val Val Pro Leu Arg Ala Arg Glu Gly Gly Val Leu Val Arg Ala Gly

135 140 145cac acc gaa gca gct gtc gat ttg gct cgc gct gca ggc ctg cgc cca 595His Thr Glu Ala Ala Val Asp Leu Ala Arg Ala Ala Gly Leu Arg Pro150 155 160 165gca ggt gtt atc tgc gaa gtg gtc agt gaa gag gac ccc acc ggc atg 643Ala Gly Val Ile Cys Glu Val Val Ser Glu Glu Asp Pro Thr Gly Met

170 175 180gct cgg gtt cct gag ctg cgc cgc ttc tgc gat gag cac gat ctg aag 691Ala Arg Val Pro Glu Leu Arg Arg Phe Cys Asp Glu His Asp Leu Lys

185 190 195ctg atc tct att gag cag ctc att gag tgg cgt cgc aag aat gaa att 739Leu Ile Ser Ile Glu Gln Leu Ile Glu Trp Arg Arg Lys Asn Glu Ile

200 205 210ttg gtg gag cgc cag gtg gaa act gtg ctg cct acc gat ttc ggc acg 787Leu Val Glu Arg Gln Val Glu Thr Val Leu Pro Thr Asp Phe Gly Thr

215 220 225ttc aag gct gtt ggt tac cgt tcc atc atc gat ggc acc gag ctt gtt 835Phe Lys Ala Val Gly Tyr Arg Ser Ile Ile Asp Gly Thr Glu Leu Val230 235 240 245gcc att gtt gcc ggc gac gtg gca tcc gac ggt ggc gaa aac gtc ctg 883Ala Ile Val Ala Gly Asp Val Ala Ser Asp Gly Gly Glu Asn Val Leu

250 255 260gtt cga gtc cac tct gag tgc ttg act ggt gat gtt ttt gga tcc cgg 931Val Arg Val His Ser Glu Cys Leu Thr Gly Asp Val Phe Gly Ser Arg

265 270 275cgc tgc gac tgt gga cag cag ctg cac gag tct ttg cgc ctg atc cag 979Arg Cys Asp Cys Gly Gln Gln Leu His Glu Ser Leu Arg Leu Ile Gln

280 285 290gaa gct ggt cgg gga gta gtg gtg tac atg cgt ggg cat gag gga cga 1027Glu Ala Gly Arg Gly Val Val Val Tyr Met Arg Gly His Glu Gly Arg

295 300 305ggc att ggt ctg ctc gcc aag cta cgc gcc tac caa ctc cag gat gaa 1075Gly Ile Gly Leu Leu Ala Lys Leu Arg Ala Tyr Gln Leu Gln AspGlu310 315 320 325ggt gcc gac acc gtc gat gcc aac ctc gca ctt ggt ctt cca gcc gat 1123Gly Ala Asp Thr Val Asp Ala Asn Leu Ala Leu Gly Leu Pro Ala Asp

330 335 340gcc cgc gaa ttt ggc acc agc gcc cag att ctc tac gac ttg ggt gtg 1171Ala Arg Glu Phe Gly Thr Ser Ala Gln Ile Leu Tyr Asp Leu Gly Val

345 350 355cgc tcg ctc aac ttg atc agc aac aac cca gcc aag aag gtg gga ctt 1219Arg Ser Leu Asn Leu Ile Ser Asn Asn Pro Ala Lys Lys Val Gly Leu

360 365 370gaa ggc cac ggc att tcc att gcc agc cga acc ccc atc cct gtt gct 1267Glu Gly His Gly Ile Ser Ile Ala Ser Arg Thr Pro Ile Pro Val Ala

375 380 385gtt cat gaa gac aat gtt cga tac ctg aaa acc aag cgt gac cgc atg 1315Val His Glu Asp Asn Val Arg Tyr Leu Lys Thr Lys Arg Asp Arg Met390 395 400 405gga cat gac ctc cca gat gtc gca ctg tgg gaa caa gag cac cca gaa 1363Gly His Asp Leu Pro Asp Val Ala Leu Trp Glu Gln Glu His Pro Glu

410415420 aac taaggagcac aacaatggct aaa 1389Asn<210>562<211>422<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>562Val Ser Glu His Glu Gln Ala His Ser Gln Leu Asp Ser Val Glu Glu 151015 Ala Ile Ala Asp Ile Ala Ala Gly Lys Ala Val Val Val Val Asp Asp

20 25 30Glu Asp Arg Glu Asn Glu Gly Asp Ile Ile Phe Ala Ala Glu Leu Ala

35 40 45Thr Pro Glu Leu Val Ala Phe Met Val Arg Tyr Ser Ser Gly Tyr Ile

50 5560Cys Ala Pro Leu Thr Ala Lys Asp Ala Asp Arg Leu Asp Leu Pro Pro 65 70 75 80Met Thr Ala His Asn Gln Asp Ala Arg Gly Thr Ala Tyr Thr Val Thr

85 90 95Val Asp Ala Asn Thr Gly Thr Thr Gly Ile Ser Ala Thr Asp Arg Ala

100 105 110His Thr Leu Arg Leu Leu Ala Asp Pro Glu Ala Asp Arg Thr Asp Phe

115 120 125Thr Arg Pro Gly His Val Val Pro Leu Arg Ala Arg Glu Gly Gly Val

130 135 140Leu Val Arg Ala Gly His Thr Glu Ala Ala Val Asp Leu Ala Arg Ala145 150 155 160Ala Gly Leu Arg Pro Ala Gly Val Ile Cys Glu Val Val Ser Glu Glu

165 170 175Asp Pro Thr Gly Met Ala Arg Val Pro Glu Leu Arg Arg Phe Cys Asp

180 185 190Glu His Asp Leu Lys Leu Ile Ser Ile Glu Gln Leu Ile Glu Trp Arg

195 200 205Arg Lys Asn Glu Ile Leu Val Glu Arg Gln Val Glu Thr Val Leu Pro

210 215 220Thr Asp Phe Gly Thr Phe Lys Ala Val Gly Tyr Arg Ser Ile Ile Asp225 230 235 240Gly Thr Glu Leu Val Ala Ile Val Ala Gly Asp Val Ala Ser Asp Gly

245 250 255Gly Glu Asn Val Leu Val Arg Val His Ser Glu Cys Leu Thr Gly Asp

260 265 270Val Phe Gly Ser Arg Arg Cys Asp Cys Gly Gln Gln Leu His Glu Ser

275 280 285Leu Arg Leu Ile Gln Glu Ala Gly Arg Gly Val Val Val Tyr Met Arg

290 295 300Gly His Glu Gly Arg Gly Ile Gly Leu Leu Ala Lys Leu Arg Ala Tyr305 310 315 320Gln Leu Gln Asp Glu Gly Ala Asp Thr Val Asp Ala Asn Leu Ala Leu

325 330 335Gly Leu Pro Ala Asp Ala Arg Glu Phe Gly Thr Ser Ala Gln Ile Leu

340 345 350Tyr Asp Leu Gly Val Arg Ser Leu Asn Leu Ile Ser Asn Asn Pro Ala

355 360 365Lys Lys Val Gly Leu Glu Gly His Gly Ile Ser Ile Ala Ser Arg Thr

370 375 380Pro Ile Pro Val Ala Val His Glu Asp Asn Val Arg Tyr Leu Lys Thr385 390 395 400Lys Arg Asp Arg Met Gly His Asp Leu Pro Asp Val Ala Leu Trp Glu

405 410 415Gln Glu His Pro Glu Asn

420<210>563<211>600<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (577)<223>RXN02249<400>563atgttcgata cctgaaaacc aagcgtgacc gcatgggaca tgacctccca gatgtcgcac 60tgtgggaaca agagcaccca gaaaactaag gagcacaaca atg gct aaa gaa gga 115

Met Ala Lys Glu Gly

1 5ttg ccg gca gtc gaa ctc ccc gac gcc agc gga tta aaa gtc gcc gta 163Leu Pro Ala Val Glu Leu Pro Asp Ala Ser Gly Leu Lys Val Ala Val

10 15 20gtc acc gca cgg tgg aac gcagaa atc tgc gac cgc ctg cac aag cac 211Val Thr Ala Arg Trp Asn Ala Glu Ile Cys Asp Arg Leu His Lys His

25 30 35gca gta gat gcg gga cgt gca gca gga gca acg gtg agc gaa tac cgc 259Ala Val Asp Ala Gly Arg Ala Ala Gly Ala Thr Val Ser Glu Tyr Arg

40 45 50gtc atc ggc gcc ctg gaa ctt cca gtc gta gtg caa gaa ctg gca cgc 307Val Ile Gly Ala Leu Glu Leu Pro Val Val Val Gln Glu Leu Ala Arg

55 60 65acc cat gac gca gta gtt gcc ttg ggc tgt gtc gtt cgt ggc ggc acc 355Thr His Asp Ala Val Val Ala Leu Gly Cys Val Val Arg Gly Gly Thr 70 75 80 85cca cac ttt gat tac gtg tgc gac tct gtc acc gaa ggc ctc acc cgc 403Pro His Phe Asp Tyr Val Cys Asp Ser Val Thr Glu Gly Leu Thr Arg

90 95 100att gct ctt gat act tcc acc cca atc ggc aac ggt gtg ttg act acc 451Ile Ala Leu Asp Thr Ser Thr Pro Ile Gly Asn Gly Val Leu Thr Thr

105 110 115aac acc gaa gag caa gcc gtg gaa cgc tcc ggt gga gaa ggc tct gta 499Asn Thr Glu Glu Gln Ala Val Glu Arg Ser Gly Gly Glu Gly Ser Val

120 125 130gag gac aaa ggc gca gag gca atg gtc gct gca ctc gat act gcc ctc 547Glu Asp Lys Gly Ala Glu Ala Met Val Ala Ala Leu Asp Thr Ala Leu

135140145 gtg ctt tct caa att cgt gca act gag ggt tagactgttc tttaaaaggt 597Val Leu Ser Gln Ile Arg Ala Thr Glu Gly 150155 ttg 600<210>564<211>159<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>564Met Ala Lys Glu Gly Leu Pro Ala Val Glu Leu Pro Asp Ala Ser Gly 151015 Leu Lys Val Ala Val Val Thr Ala Arg Trp AsnAla Glu Ile Cys Asp

20 25 30Arg Leu His Lys His Ala Val Asp Ala Gly Arg Ala Ala Gly Ala Thr

35 40 45Val Ser Glu Tyr Arg Val Ile Gly Ala Leu Glu Leu Pro Val Val Val

50 55 60Gln Glu Leu Ala Arg Thr His Asp Ala Val Val Ala Leu Gly Cys Val 65 70 75 80Val Arg Gly Gly Thr Pro His Phe Asp Tyr Val Cys Asp Ser Val Thr

85 90 95Glu Gly Leu Thr Arg Ile Ala Leu Asp Thr Ser Thr Pro Ile Gly Asn

100 105 110Gly Val Leu Thr Thr Asn Thr Glu Glu Gln Ala Val Glu Arg Ser Gly

115 120 125Gly Glu Gly Ser Val Glu Asp Lys Gly Ala Glu Ala Met Val Ala Ala

130135140 Leu Asp Thr Ala Leu Val Leu Ser Gln Ile Arg Ala Thr Glu Gly 145150155<210>565<211>600<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (577)<223>FRXA02249<400>565atgttcgata cctgaaaacc aagcgtgacc gcatgggaca tgacctccca gatgtcgcac 60tgtgggaaca agagcaccca gaaaactaag gagcacaaca atg gct aaa gaa gga 115

Met Ala Lys Glu Gly

1 5ttg ccg gca gtc gaa ctc ccc gac gcc agc gga tta aaa gtc gcc gta 163Leu Pro Ala Val Glu Leu Pro Asp Ala Ser Gly Leu Lys Val Ala Val

10 15 20gtc acc gca cgg tgg aac gca gaa atc tgc gac cgc ctg cac aag cac 211Val Thr Ala Arg Trp Asn Ala Glu Ile Cys Asp Arg Leu His Lys His

25 30 35gca gta gat gcg gga cgt gca gca gga gca acg gtg agc gaa tac cgc 259Ala Val Asp Ala Gly Arg Ala Ala Gly Ala Thr Val Ser Glu Tyr Arg

40 45 50gtc atc ggc gcc ctg gaa ctt cca gtc gta gtg caa gaa ctg gca cgc 307Val Ile Gly Ala Leu Glu Leu Pro Val Val Val Gln Glu Leu Ala Arg

55 60 65acc cat gac gca gta gtt gcc ttg ggc tgt gtc gtt cgt ggc ggc acc 355Thr His Asp Ala Val Val Ala Leu Gly Cys Val Val Arg Gly Gly Thr 70 75 80 85cca cac ttt gat tac gtg tgc gac tct gtc acc gaa ggc ctc acc cgc 403Pro His Phe Asp Tyr Val Cys Asp Ser Val Thr Glu Gly Leu Thr Arg

90 95 100att gct ctt gat act tcc acc cca atc ggc aac ggt gtg ttg act acc 451Ile Ala Leu Asp Thr Ser Thr Pro Ile Gly Asn Gly Val Leu Thr Thr

105 110 115aac acc gaa gag caa gcc gtg gaa cgc tcc ggt gga gaa ggc tct gta 499Asn Thr Glu Glu Gln Ala Val Glu Arg Ser Gly Gly Glu Gly Ser Val

120 125 130gag gac aaa ggc gca gag gca atg gtc gct gca ctc gat act gcc ctc 547Glu Asp Lys Gly Ala Glu Ala Met Val Ala Ala Leu Asp Thr Ala Leu

135140145 gtg ctt tct caa att cgt gca act gag ggt tagactgttc tttaaaaggt 597Val Leu Ser Gln Ile Arg Ala Thr Glu Gly 150155 ttg 600<210>566<211>159<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>566Met Ala Lys Glu Gly Leu Pro Ala Val Glu Leu Pro Asp Ala Ser Gly 151015 Leu Lys Val Ala Val Val Thr Ala Arg Trp Asn Ala Glu Ile Cys Asp

2025 30Arg Leu His Lys His Ala Val Asp Ala Gly Arg Ala Ala Gly Ala Thr

35 40 45Val Ser Glu Tyr Arg Val Ile Gly Ala Leu Glu Leu Pro Val Val Val

50 55 60Gln Glu Leu Ala Arg Thr His Asp Ala Val Val Ala Leu Gly Cys Val 65 70 75 80Val Arg Gly Gly Thr Pro His Phe Asp Tyr Val Cys Asp Ser Val Thr

85 90 95Glu Gly Leu Thr Arg Ile Ala Leu Asp Thr Ser Thr Pro Ile Gly Asn

100 105 110Gly Val Leu Thr Thr Asn Thr Glu Glu Gln Ala Val Glu Arg Ser Gly

115 120 125Gly Glu Gly Ser Val Glu Asp Lys Gly Ala Glu Ala Met Val Ala Ala

130135140 Leu Asp Thr Ala Leu Val Leu Ser Gln Ile Arg Ala Thr Glu Gly 145150155<210>567<211>702<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (679)<223>RXA02250<400>567caactgaggg ttagactgtt ctttaaaagg tttgacgcct cggtttaatg cctagcagga 60tgcgcgccac cgctaattag ttctaaggat ttgtgaaatc gtg aca acc aac gcc 115

Val Thr Thr Asn Ala

1 5ccc gac gga gca acg aac aac atc aac aac gca cat tcg ggc gct gtc 163Pro Asp Gly Ala Thr Asn Asn Ile Asn Asn Ala His Ser Gly Ala Val

10 15 20ggg aag cca aag gta cag ctc agc gat gcg gaa att cag gaa tac acc 211Gly Lys Pro Lys Val Gln Leu Ser Asp Ala Glu Ile Gln Glu Tyr Thr

25 30 35gca gct ttc gct ggc acc acc aca acc aag cca tgg gag ctg gag gtg 259Ala Ala Phe Ala Gly Thr Thr Thr Thr Lys Pro Trp Glu Leu Glu Val

40 45 50acc aca aag ttt ctg aaa aag atc gcg tgg gta gcc gtg gtt gtc atc 307Thr Thr Lys Phe Leu Lys Lys Ile Ala Trp Val Ala Val Val Val Ile

55 60 65atg gcc gtt cac atc ttc atg ggt gcc gtg gtg gac gtc gat ttc acc 355Met Ala Val His Ile Phe Met Gly Ala Val Val Asp Val Asp Phe Thr 70 75 80 85ggt gca gcg gtc acc ttt gtt gac act ctg gca ttc cca gcg ttg ggc 403Gly Ala Ala Val Thr Phe Val Asp Thr Leu Ala Phe Pro Ala Leu Gly

90 95 100atc atc ttc tcc gtt ctt gtg ttc ttg gga ctg act cgc cct cgc gtg 451Ile Ile Phe Ser Val Leu Val Phe Leu Gly Leu Thr Arg Pro Arg Val

105 110 115cgt gcc aac gaa gac ggc gtt gag gtg cgt aac ttc atc gga act cgt 499Arg Ala Asn Glu Asp Gly Val Glu Val Arg Asn Phe Ile Gly Thr Arg

120 125 130ttc tac cca tgg gtt gtc atc tac ggc atg tct ttc ccc aag ggc agc 547Phe Tyr Pro Trp Val Val Ile Tyr Gly Met Ser Phe Pro Lys Gly Ser

135 140 145agc gtg gca cgt ttg gag ctt cca gac ttt gaa ttc gtt ccc atg tgg 595Ser Val Ala Arg Leu Glu Leu Pro Asp Phe Glu Phe Val Pro Met Trp150 155 160 165gct ttc cag tcc cgc gat gga gaa gat gtg gtg cgc gcg gtt gcg acc 643Ala Phe Gln Ser Arg Asp Gly Glu Asp Val Val Arg Ala Val Ala Thr

170 175 180ttc cgc gac ctc gaa aac aag tac atg cca gag gac taattaagct 689Phe Arg Asp Leu Glu Asn Lys Tyr Met Pro Glu Asp

185190 gtggctgatc caa 702<210>568<211>193<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>568Val Thr Thr Asn Ala Pro Asp Gly Ala Thr Asn Asn Ile Asn Asn Ala 151015 His Ser Gly Ala Val Gly Lys Pro Lys Val Gln Leu Ser Asp Ala Glu

20 25 30Ile Gln Glu Tyr Thr Ala Ala Phe Ala Gly Thr Thr Thr Thr Lys Pro

35 40 45Trp Glu Leu Glu Val Thr Thr Lys Phe Leu Lys Lys Ile Ala Trp Val

50 55 60Ala Val Val Val Ile Met Ala Val His Ile Phe Met Gly Ala Val Val 65 70 75 80Asp Val Asp Phe Thr Gly Ala Ala Val Thr Phe Val Asp Thr Leu Ala

85 90 95Phe Pro Ala Leu Gly Ile Ile Phe Ser Val Leu Val Phe Leu Gly Leu

100 105 110Thr Arg Pro Arg Val Arg Ala Asn Glu Asp Gly Val Glu Val Arg Asn

115 120 125Phe Ile Gly Thr Arg Phe Tyr Pro Trp Val Val Ile Tyr Gly Met Ser

130 135 140Phe Pro Lys Gly Ser Ser Val Ala Arg Leu Glu Leu Pro Asp Phe Glu145 150 155 160Phe Val Pro Met Trp Ala Phe Gln Ser Arg Asp Gly Glu Asp Val Val

165 170 175Arg Ala Val Ala Thr Phe Arg Asp Leu Glu Asn Lys Tyr Met Pro Glu

180185190 Asp<210>569<211>1146<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<1123><223>RXA01489<400>569gtcatgggat gtcattccgg cgggcttgtc gacgatcacg agtccaggtt taggggcagg 60agcattcatg tctgttgagt ctatgccgta gtctaaaaca gtg gat att tgg agt 115

Val Asp Ile Trp Ser

1 5gga cta gac agc gtt ccg gct gat ctt caa gga tca gta gtc acc att 163Gly Leu Asp Ser Val Pro Ala Asp Leu Gln Gly Ser Val Val Thr Ile

10 15 20ggt gtg ttt gat ggg ctc cac cgg ggg cat caa agt tta atc ggc gag 211Gly Val Phe Asp Gly Leu His Arg Gly His Gln Ser Leu Ile Gly Glu

25 30 35gcc aag aag cag gcc gag gag ctg ggt gtg cct tgt gtc atg gtg acc 259Ala Lys Lys Gln Ala Glu Glu Leu Gly Val Pro Cys Val Met Val Thr

40 45 50ttt gac ccg cat ccg atc gct gtg ttt ttg cca ggt aaa gag cca acc 307Phe Asp Pro His Pro Ile Ala Val Phe Leu Pro Gly Lys Glu Pro Thr

55 60 65cgt ttg gct cct ttg gat tat cgc ctt aat ttg gct gcg gaa tgt ggc 355Arg Leu Ala Pro Leu Asp Tyr Arg Leu Asn Leu Ala Ala Glu Cys Gly 70 75 80 85gtc gat gct gcg ttg gtt att gat ttc act aaa gaa ctc gca ggt ctg 403Val Asp Ala Ala Leu Val Ile Asp Phe Thr Lys Glu Leu Ala Gly Leu

90 95 100agc gct gaa gag tat ttc aca acc atg atc gtg gat acg ctg cat gcg 451Ser Ala Glu Glu Tyr Phe Thr Thr Met Ile Val Asp Thr Leu His Ala

105 110 115cgt tca gtt gtg gtg ggg gag aac ttc acc ttc ggt gtc aat ggc gct 499Arg Ser Val Val Val Gly Glu Asn Phe Thr Phe Gly Val Asn Gly Ala

120 125 130ggc act gag tcc acg atg cgg gaa ttg gga caa aag ttt ggc gtg aat 547Gly Thr Glu Ser Thr Met Arg Glu Leu Gly Gln Lys Phe Gly Val Asn

135 140 145gtc acg att gct ccg ctg ctg cat gat gat gac cag cgt att tgc tcc 595Val Thr Ile Ala Pro Leu Leu His Asp Asp Asp Gln Arg Ile Cys Ser150 155 160 165acc ttg gtg cgc gat tac ttg gat cag ggc gag gtt gag cgc gcg aac 643Thr Leu Val Arg Asp Tyr Leu Asp Gln Gly Glu Val Glu Arg Ala Asn

170 175 180tgg gcg ctt ggt cga cgc tat gcc gtg cgc ggc gaa gtt gtc cgt ggt 691Trp Ala Leu Gly Arg Arg Tyr Ala Val Arg Gly Glu Val Val Arg Gly

185 190 195gct ggc cgt ggc ggc aaa gaa ttg ggc tat ccc acc gcg aat ctc tac 739Ala Gly Arg Gly Gly Lys Glu Leu Gly Tyr Pro Thr Ala Asn Leu Tyr

200 205 210ctg ccg acc tct gtg gcg ctg ccc gcc gat ggc gtg tat gca ggc tgg 787Leu Pro Thr Ser Val Ala Leu Pro Ala Asp Gly Val Tyr Ala Gly Trp

215 220 225ttc acc atc acc gat gac cgc gaa atc gac aag gaa atc tcc cgc gat 835Phe Thr Ile Thr Asp Asp Arg Glu Ile Asp Lys Glu Ile Ser Arg Asp230 235 240 245atc gac ggc acc atg gtt cca ggc gtg cgt tac caa act gcc att tcc 883Ile Asp Gly Thr Met Val Pro Gly Val Arg Tyr Gln Thr Ala Ile Ser

250 255 260gtg ggc acc aat ccc acc ttc ggc gat gag cga cgc agc gtc gag gca 931Val Gly Thr Asn Pro Thr Phe Gly Asp Glu Arg Arg Ser Val Glu Ala

265 270 275ttc atc ctc gac cag gaa gcc gac ctg tac ggt cac cat gtc atg gtg 979Phe Ile Leu Asp Gln Glu Ala Asp Leu Tyr Gly His His Val Met Val

280 285 290gaa ttc gtg gga cac ttg cgc gac atg gtc aaa ttc aac ggc gtc gac 1027Glu Phe Val Gly His Leu Arg Asp Met Val Lys Phe Asn Gly Val Asp

295 300 305gag cta cta gac gcc atg gcc cga gat gtc acc aac gcc cgc gac atc 1075Glu Leu Leu Asp Ala Met Ala Arg Asp Val Thr Asn Ala Arg Asp Ile310 315 320 325ctt gcc aaa gac aaa ttg ctt ctc gac gcc gac acc cag ccc agc gct 1123Leu Ala Lys Asp Lys Leu Leu Leu Asp Ala Asp Thr Gln Pro Ser Ala

330335340 taaggccggt caccggccat caa 1146<210>570<211>341<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>570Val Asp Ile Trp Ser Gly Leu Asp Ser Val Pro Ala Asp Leu Gln Gly 151015 Ser Val Val Thr Ile Gly Val Phe Asp Gly Leu His Arg Gly His Gln

20 25 30Ser Leu Ile Gly Glu Ala Lys Lys Gln Ala Glu Glu Leu Gly Val Pro

35 40 45Cys Val Met Val Thr Phe Asp Pro His Pro Ile Ala Val Phe Leu Pro

50 55 60Gly Lys Glu Pro Thr Arg Leu Ala Pro Leu Asp Tyr Arg Leu Asn Leu 65 70 75 80Ala Ala Glu Cys Gly Val Asp Ala Ala Leu Val Ile Asp Phe Thr Lys

85 90 95Glu Leu Ala Gly Leu Ser Ala Glu Glu Tyr Phe Thr Thr Met Ile Val

100 105 110Asp Thr Leu His Ala Arg Ser Val Val Val Gly Glu Asn Phe Thr Phe

115 120 125Gly Val Asn Gly Ala Gly Thr Glu Ser Thr Met Arg Glu Leu Gly Gln

130 135 140Lys Phe Gly Val Asn Val Thr Ile Ala Pro Leu Leu His Asp Asp Asp145 150 155 160Gln Arg Ile Cys Ser Thr Leu Val Arg Asp Tyr Leu Asp Gln Gly Glu

165 170 175Val Glu Arg Ala Asn Trp Ala Leu Gly Arg Arg Tyr Ala Val Arg Gly

180 185 190Glu Val Val Arg Gly Ala Gly Arg Gly Gly Lys Glu Leu Gly Tyr Pro

195 200 205Thr Ala Asn Leu Tyr Leu Pro Thr Ser Val Ala Leu Pro Ala Asp Gly

210 215 220Val Tyr Ala Gly Trp Phe Thr Ile Thr Asp Asp Arg Glu Ile Asp Lys225 230 235 240Glu Ile Ser Arg Asp Ile Asp Gly Thr Met Val Pro Gly Val Arg Tyr

245 250 255Gln Thr Ala Ile Ser Val Gly Thr Asn Pro Thr Phe Gly Asp Glu Arg

260 265 270Arg Ser Val Glu Ala Phe Ile Leu Asp Gln Glu Ala Asp Leu Tyr Gly

275 280 285His His Val Met Val Glu Phe Val Gly His Leu Arg Asp Met Val Lys

290 295 300Phe Asn Gly Val Asp Glu Leu Leu Asp Ala Met Ala Arg Asp Val Thr305 310 315 320Asn Ala Arg Asp Ile Leu Ala Lys Asp Lys Leu Leu Leu Asp Ala Asp

325 330 335Thr Gln Pro Ser Ala

340<210>571<211>1197<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1174)<223>RXA02135<400>571cgtgtcgcag cgatttgcga gagggttgtc ttcgtggttg ctggtctgcc actagagttg 60aaaacgtttt aagaaaacag tcggtttgaa ggagttgtta atg gtt cca gca gag 115

Met Val Pro Ala Glu

1 5ctt ttt gcg cgt gtg gaa ttt ccg gat cat aaa atc ctg gct cag acg 163Leu Phe Ala Arg Val Glu Phe Pro Asp His Lys Ile Leu Ala Gln Thr

10 15 20aag gat ttc cat gac tcc ctc acc aag cca ccc gga tct ttg ggc aag 211Lys Asp Phe His Asp Ser Leu Thr Lys Pro Pro Gly Ser Leu Gly Lys

25 30 35ttg gag cag atc ggc tgt ttc att tcc gca tgc cag ggc cag att ccg 259Leu Glu Gln Ile Gly Cys Phe Ile Ser Ala Cys Gln Gly Gln Ile Pro

40 45 50cca cgt cca ctc aac aac tca aag atc gtt gtt ttc gct ggc gat cac 307Pro Arg Pro Leu Asn Asn Ser Lys Ile Val Val Phe Ala Gly Asp His

55 60 65ggc gtt gca act aaa ggc gtg tcc gcg tac cca tcc tca gta agc ttg 355Gly Val Ala Thr Lys Gly Val Ser Ala Tyr Pro Ser Ser Val Ser Leu 70 75 80 85cag atg gct gaa aac att aca aac ggt ggc gcc gcc atc aac gtg att 403Gln Met Ala Glu Asn Ile Thr Asn Gly Gly Ala Ala Ile Asn Val Ile

90 95 100gca cgc acc acc ggc acg tcc gtc cga ctt att gat acc tcc ctc gac 451Ala Arg Thr Thr Gly Thr Ser Val Arg Leu Ile Asp Thr Ser Leu Asp

105 110115cac gaa gca tgg ggc gac gag cgc gta tct agg tcc tgc gga tcc atc 499His Glu Ala Trp Gly Asp Glu Arg Val Ser Arg Ser Cys Gly Ser Ile

120 125 130gat gtt gaa gac gcc atg acc caa gaa cag gtc gaa cgc gca ctg aag 547Asp Val Glu Asp Ala Met Thr Gln Glu Gln Val Glu Arg Ala Leu Lys

135 140 145atc ggt aag cgc att gcg gat caa gaa gtg gac gca ggc gcc gac att 595Ile Gly Lys Arg Ile Ala Asp Gln Glu Val Asp Ala Gly Ala Asp Ile150 155 160 165tta atc ccc ggc gat tta gga att ggc aac acc acc acc gcc gct gcc 643Leu Ile Pro Gly Asp Leu Gly Ile Gly Asn Thr Thr Thr Ala Ala Ala

170 175 180ctc gtt gga acg ttc acc ctc gca gag cct gtt gtt gtc gta ggc cgc 691Leu Val Gly Thr Phe Thr Leu Ala Glu Pro Val Val Val Val Gly Arg

185 190 195ggc acc gga atc gac gat gaa gcc tgg aaa ctc aaa gtc tcc gcg atc 739Gly Thr Gly Ile Asp Asp Glu Ala Trp Lys Leu Lys Val Ser Ala Ile

200 205 210cgc gac gcc atg ttc cgc gcc cgc gac ctg cgc caa gac ccc atc gcc 787Arg Asp Ala Met Phe Arg Ala Arg Asp Leu Arg Gln Asp Pro Ile Ala

215 220 225atc gcc cgg aaa atc tct tcc cca gac ctt gca gcc atg gca gca ttc 835Ile Ala Arg Lys Ile Ser Ser Pro Asp Leu Ala Ala Met Ala Ala Phe230 235 240 245att gcc caa gca gca gtt cga cgc acc ccc gtg ctt ctc gac ggc gtt 883Ile Ala Gln Ala Ala Val Arg Arg Thr Pro Val Leu Leu Asp Gly Val

250 255 260gta gtc acc gcc gca gcc ctc cta gcc aac aaa ctg gcc cca ggt gcc 931Val Val Thr Ala Ala Ala Leu Leu Ala Asn Lys Leu Ala Pro Gly Ala

265 270 275agg cgt tgg ttc atc gca gga cac cgc tcc acc gaa cca gcg cat tcc 979Arg Arg Trp Phe Ile Ala Gly His Arg Ser Thr Glu Pro Ala His Ser

280 285 290gta gct cta aac gca ctg gcc ctt gat ccc atc ctg gaa ctt gga atg 1027Val Ala Leu Asn Ala Leu Ala Leu Asp Pro Ile Leu Glu Leu Gly Met

295 300 305tcc ctt ggc gaa ggc tcc ggc gca gcc acc gca ctc ccc ctg gtc aag 1075Ser Leu Gly Glu Gly Ser Gly Ala Ala Thr Ala Leu Pro Leu Val Lys310 315 320 325att gcc gtt gac ctg atg aac gac atg tcg aca ttt tct tcc gcc ggc 1123Ile Ala Val Asp Leu Met Asn Asp Met Ser Thr Phe Ser Ser Ala Gly

330 335 340gtc gat gga ccc cta aac gcc tct tcc gaa gcg ccc gag caa aac acg 1171Val Asp Gly Pro Leu Asn Ala Ser Ser Glu Ala Pro Glu Gln Asn Thr

345350355 gag taactttcta agcgatgtcc ggc 1197Glu<210>572<211>358<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>572Met Val Pro Ala Glu Leu Phe Ala Arg Val Glu Phe Pro Asp His Lys 151015 Ile Leu Ala Gln Thr Lys Asp Phe His Asp Ser Leu Thr Lys Pro Pro

20 25 30Gly Ser Leu Gly Lys Leu Glu Gln Ile Gly Cys Phe Ile Ser Ala Cys

35 40 45Gln Gly Gln Ile Pro Pro Arg Pro Leu Asn Asn Ser Lys Ile Val Val

50 55 60Phe Ala Gly Asp His Gly Val Ala Thr Lys Gly Val Ser Ala Tyr Pro 65 70 75 80Ser Ser Val Ser Leu Gln Met Ala GluAsn Ile Thr Asn Gly Gly Ala

85 90 95Ala Ile Asn Val Ile Ala Arg Thr Thr Gly Thr Ser Val Arg Leu Ile

100 105 110Asp Thr Ser Leu Asp His Glu Ala Trp Gly Asp Glu Arg Val Ser Arg

115 120 125Ser Cys Gly Ser Ile Asp Val Glu Asp Ala Met Thr Gln Glu Gln Val

130 135 140Glu Arg Ala Leu Lys Ile Gly Lys Arg Ile Ala Asp Gln Glu Val Asp145 150 155 160Ala Gly Ala Asp Ile Leu Ile Pro Gly Asp Leu Gly Ile Gly Asn Thr

165 170 175Thr Thr Ala Ala Ala Leu Val Gly Thr Phe Thr Leu Ala Glu Pro Val

180 185 190Val Val Val Gly Arg Gly Thr Gly Ile Asp Asp Glu Ala Trp Lys Leu

195 200 205Lys Val Ser Ala Ile Arg Asp Ala Met Phe Arg Ala Arg Asp Leu Arg

210 215 220Gln Asp Pro Ile Ala Ile Ala Arg Lys Ile Ser Ser Pro Asp Leu Ala225 230 235 240Ala Met Ala Ala Phe Ile Ala Gln Ala Ala Val Arg Arg Thr Pro Val

245 250 255Leu Leu Asp Gly Val Val Val Thr Ala Ala Ala Leu Leu Ala Asn Lys

260 265 270Leu Ala Pro Gly Ala Arg Arg Trp Phe Ile Ala Gly His Arg Ser Thr

275 280 285Glu Pro Ala His Ser Val Ala Leu Asn Ala Leu Ala Leu Asp Pro Ile

290 295 300Leu Glu Leu Gly Met Ser Leu Gly Glu Gly Ser Gly Ala Ala Thr Ala305 310 315 320Leu Pro Leu Val Lys Ile Ala Val Asp Leu Met Asn Asp Met Ser Thr

325 330 335Phe Ser Ser Ala Gly Val Asp Gly Pro Leu Asn Ala Ser Ser Glu Ala

340 345 350Pro Glu Gln Asn Thr Glu

355<210>573<211>1146<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). - (1123)<223>RXA01489<400>573gtcatgggat gtcattccgg cgggcttgtc gacgatcacg agtccaggtt taggggcagg agcattcatg tctgttgagt ctatgccgta gtctaaaaca gtg gat att tgg agt 115

Val Asp Ile Trp Ser

1 5gga cta gac agc gtt ccg gct gat ctt caa gga tca gta gtc acc att 163Gly Leu Asp Ser Val Pro Ala Asp Leu Gln Gly Ser Val Val Thr Ile

10 15 20ggt gtg ttt gat ggg ctc cac cgg ggg cat caa agt tta atc ggc gag 211Gly Val Phc Asp Gly Leu His Arg Gly His Gln Ser Leu Ile Gly Glu

25 30 35gcc aag aag cag gcc gag gag ctg ggt gtg cct tgt gtc atg gtg acc 259Ala Lys Lys Gln Ala Glu Glu Leu Gly Val Pro Cys Val Met Val Thr

40 45 50ttt gac ccg cat ccg atc gct gtg ttt ttg cca ggt aaa gag cca acc 307Phe Asp Pro His Pro Ile Ala Val Phe Leu Pro Gly Lys Glu Pro Thr

55 60 65cgt ttg gct cct ttg gat tat cgc ctt aat ttg gct gcg gaa tgt ggc 355Arg Leu Ala Pro Leu Asp Tyr Arg Leu Asn Leu AlaAla Glu Cys Gly 70 75 80 85gtc gat gct gcg ttg gtt att gat ttc act aaa gaa ctc gca ggt ctg 403Val Asp Ala Ala Leu Val Ile Asp Phe Thr Lys Glu Leu Ala Gly Leu

90 95 100agc gct gaa gag tat ttc aca acc atg atc gtg gat acg ctg cat gcg 451Ser Ala Glu Glu Tyr Phe Thr Thr Met Ile Val Asp Thr Leu His Ala

105 110 115cgt tca gtt gtg gtg ggg gag aac ttc acc ttc ggt gtc aat ggc gct 499Arg Ser Val Val Val Gly Glu Asn Phe Thr Phe Gly Val Asn Gly Ala

120 125 130ggc act gag tcc acg atg cgg gaa ttg gga caa aag ttt ggc gtg aat 547Gly Thr Glu Ser Thr Met Arg Glu Leu Gly Gln Lys Phe Gly Val Asn

135 140 145gtc acg att gct ccg ctg ctg cat gat gat gac cag cgt att tgc tcc 595Val Thr Ile Ala Pro Leu Leu His Asp Asp Asp Gln Arg Ile Cys Ser150 155 160 165acc ttg gtg cgc gat tac ttg gat cag ggc gag gtt gag cgc gcg aac 643Thr Leu Val Arg Asp Tyr Leu Asp Gln Gly Glu Val Glu Arg Ala Asn

170 175 180tgg gcg ctt ggt cga cgc tat gcc gtg cgc ggc gaa gtt gtc cgt ggt 691Trp Ala Leu Gly Arg Arg Tyr Ala Val Arg Gly Glu Val Val Arg Gly

185 190 195gct ggc cgt ggc ggc aaa gaa ttg ggc tat ccc acc gcg aat ctc tac 739Ala Gly Arg Gly Gly Lys Glu Leu Gly Tyr Pro Thr Ala Asn Leu Tyr

200 205 210ctg ccg acc tct gtg gcg ctg ccc gcc gat ggc gtg tat gca ggc tgg 787Leu Pro Thr Ser Val Ala Leu Pro Ala Asp Gly Val Tyr Ala Gly Trp

215 220225ttc acc atc acc gat gac cgc gaa atc gac aag gaa atc tcc cgc gat 835Phe Thr Ile Thr Asp Asp Arg Glu Ile Asp Lys Glu Ile Ser Arg Asp230 235 240 245atc gac ggc acc atg gtt cca ggc gtg cgt tac caa act gcc att tcc 883Ile Asp Gly Thr Met Val Pro Gly Val Arg Tyr Gln Thr Ala Ile Ser

250 255 260gtg ggc acc aat ccc acc ttc ggc gat gag cga cgc agc gtc gag gca 931Val Gly Thr Asn Pro Thr Phe Gly Asp Glu Arg Arg Ser Val Glu Ala

265 270 275ttc atc ctc gac cag gaa gcc gac ctg tac ggt cac cat gtc atg gtg 979Phe Ile Leu Asp Gln Glu Ala Asp Leu Tyr Gly His His Val Met Val

280 285 290gaa ttc gtg gga cac ttg cgc gac atg gtc aaa ttc aac ggc gtc gac 1027Glu Phe Val Gly His Leu Arg Asp Met Val Lys Phe Asn Gly Val Asp

295 300 305gag cta cta gac gcc atg gcc cga gat gtc acc aac gcc cgc gac atc 1075Glu Leu Leu Asp Ala Met Ala Arg Asp Val Thr Asn Ala Arg Asp Ile310 315 320 325ctt gcc aaa gac aaa ttg ctt ctc gac gcc gac acc cag ccc agc gct 1123Leu Ala Lys Asp Lys Leu Leu Leu Asp Ala Asp Thr Gln Pro Ser Ala

330335340 taaggccggt caccggccat caa 1146<210>574<211>341<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>574Val Asp Ile Trp Ser Gly Leu Asp Ser Val Pro Ala Asp Leu Gln Gly 151015 Ser Val Val Thr Ile Gly Val Phe Asp Gly Leu His Arg Gly His Gln

20 25 30Ser Leu Ile Gly Glu Ala Lys Lys Gln Ala Glu Glu Leu Gly Val Pro

35 40 45Cys Val Met Val Thr Phe Asp Pro His Pro Ile Ala Val Phe Leu Pro

50 55 60Gly Lys Glu Pro Thr Arg Leu Ala Pro Leu Asp Tyr Arg Leu Asn Leu 65 70 75 80Ala Ala Glu Cys Gly Val Asp Ala Ala Leu Val Ile Asp Phe Thr Lys

85 90 95Glu Leu Ala Gly Leu Ser Ala Glu Glu Tyr Phe Thr Thr Met Ile Val

100 105 110Asp Thr Leu His Ala Arg Ser Val Val Val Gly Glu Asn Phe Thr Phe

115 120 125Gly Val Asn Gly Ala Gly Thr Glu Ser Thr Met Arg Glu Leu Gly Gln

130 135 140Lys Phe Gly Val Asn Val Thr Ile Ala Pro Leu Leu His Asp Asp Asp145 150 155 160Gln Arg Ile Cys Ser Thr Leu Val Arg Asp Tyr Leu Asp Gln Gly Glu

165 170 175Val Glu Arg Ala Asn Trp Ala Leu Gly Arg Arg Tyr Ala Val Arg Gly

180 185 190Glu Val Val Arg Gly Ala Gly Arg Gly Gly Lys Glu Leu Gly Tyr Pro

195 200 205Thr Ala Asn Leu Tyr Leu Pro Thr Ser Val Ala Leu Pro Ala Asp Gly

210 215 220Val Tyr Ala Gly Trp Phe Thr Ile Thr Asp Asp Arg Glu Ile Asp Lys225 230 235 240Glu Ile Ser Arg Asp Ile Asp Gly Thr Met Val Pro Gly Val Arg Tyr

245 250 255Gln Thr Ala Ile Ser Val Gly Thr Asn Pro Thr Phe Gly Asp Glu Arg

260 265 270Arg Ser Val Glu Ala Phe Ile Leu Asp Gln Glu Ala Asp Leu Tyr Gly

275 280 285His His Val Met Val Glu Phe Val Gly His Leu Arg Asp Met Val Lys

290 295 300Phe Asn Gly Val Asp Glu Leu Leu Asp Ala Met Ala Arg Asp Val Thr305 310 315 320Asn Ala Arg Asp Ile Leu Ala Lys Asp Lys Leu Leu Leu Asp Ala Asp

325 330 335Thr Gln Pro Ser Ala

340<210>575<211>805<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(87). (782)<223>RXN01712<400>575gccggcttag gctcctccga ccagaacccc actggcacct ttggataaca ccattccgtg 60taaacaagct ggcctagact tgaaac atg gtc gat atc ttg gaa ctc atc ggt 113

Met Val Asp Ile Leu Glu Leu Ile Gly

1 5ccc cta cct ttt gtg tct acg cca gag tta agg gca att gtc gtg act 161Pro Leu Pro Phe Val Ser Thr Pro Glu Leu Arg Ala Ile Val Val Thr 10 15 20 25gcc att aat ggt tcc acc act att aat ggc acg tct ggt cag ctt gga 209Ala Ile Asn Gly Ser Thr Thr Ile Asn Gly Thr Ser Gly Gln Leu Gly

30 35 40aat tcc acg gat acg gaa ctt ctg ttg gcg ctt cgc agg tgg tcg gac 257Asn Ser Thr Asp Thr Glu Leu Leu Leu Ala Leu Arg Arg Trp Ser Asp

45 50 55gtg gtg ttg gtt ggg tcg agc acg gtg aag gct gaa aat tat ggt ggc 305Val Val Leu Val Gly Ser Ser Thr Val Lys Ala Glu Asn Tyr Gly Gly

60 65 70gtg gag gtt tcg cct gaa atc cag aag caa cgc cag gag ttg ggt cag 353Val Glu Val Ser Pro Glu Ile Gln Lys Gln Arg Gln Glu Leu Gly Gln

75 80 85gaa gcg att ccg ccg att gcg gtg atg tca ggg tcg ttg aat ttt gat 401Glu Ala Ile Pro Pro Ile Ala Val Met Ser Gly Ser Leu Asn Phe Asp 90 95 100 105gtg gat act cgc ttt ttc ctt gag gcc gaa gtg ccg ccg atc atc atc 449Val Asp Thr Arg Phe Phe Leu Glu Ala Glu Val Pro Pro Ile Ile Ile

110 115 120acg gat aat tcc gat caa gca aag cag cag cgg ctt gtg gat gct ggg 497Thr Asp Asn Ser Asp Gln Ala Lys Gln Gln Arg Leu Val Asp Ala Gly

125 130 135gct cag gtt att gag gtg gag acg ttg acg gcg gag gtt ggc gtc gaa 545Ala Gln Val Ile Glu Val Glu Thr Leu Thr Ala Glu Val Gly Val Glu

140 145 150aag ctt agg tct ttg ggt tac gcc cgc att gat tgt gag ggc ggt gca 593Lys Leu Arg Ser Leu Gly Tyr Ala Arg Ile Asp Cys Glu Gly Gly Ala

155 160 165acg ttg tat ggg cag atg ttg gcc gcc gat ctt gtt gat gtg tgg cat 641Thr Leu Tyr Gly Gln Met Leu Ala Ala Asp Leu Val Asp Val Trp His170 175 180 185cac acg att gat ccg acg ttg tcg ggc agc gtg gag cgc ccc acg gtg 689His Thr Ile Asp Pro Thr Leu Ser Gly Ser Val Glu Arg Pro Thr Val

190 195 200aag ggc ggc gat gat gcg ccg cgc cga ttc gcg ttg gag cac gtc ttt 737Lys Gly Gly Asp Asp Ala Pro Arg Arg Phe Ala Leu Glu His Val Phe

205 210 215gtc gat gat gac agc acc cta ttc ttg cgg tat aag cgc gcc aag 782Val Asp Asp Asp Ser Thr Leu Phe Leu Arg Tyr Lys Arg Ala Lys

220225230 tgagtgttgg actctccgga tct 805<805>576<211>232<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>576Met Val Asp Ile Leu Glu Leu Ile Gly Pro Leu Pro Phe Val Ser Thr 151015 Pro Glu Leu Arg Ala Ile Val Val Thr Ala Ile Asn Gly Ser Thr Thr

20 25 30Ile Asn Gly Thr Ser Gly Gln Leu Gly Asn Ser Thr Asp Thr Glu Leu

35 40 45Leu Leu Ala Leu Arg Arg Trp Ser Asp Val Val Leu Val Gly Ser Ser

50 55 60Thr Val Lys Ala Glu Asn Tyr Gly Gly Val Glu Val Ser Pro Glu Ile 65 70 75 80Gln Lys Gln Arg Gln Glu Leu Gly Gln Glu Ala Ile Pro Pro Ile Ala

85 90 95Val Met Ser Gly Ser Leu Asn Phe Asp Val Asp Thr Arg Phe Phe Leu

100 105 110Glu Ala Glu Val Pro Pro Ile Ile Ile Thr Asp Asn Ser Asp Gln Ala

115 120 125Lys Gln Gln Arg Leu Val Asp Ala Gly Ala Gln Val Ile Glu Val Glu

130 135 140Thr Leu Thr Ala Glu Val Gly Val Glu Lys Leu Arg Ser Leu Gly Tyr145 150 155 160Ala Arg Ile Asp Cys Glu Gly Gly Ala Thr Leu Tyr Gly Gln Met Leu

165 170 175Ala Ala Asp Leu Val Asp Val Trp His His Thr Ile Asp Pro Thr Leu

180 185 190Ser Gly Ser Val Glu Arg Pro Thr Val Lys Gly Gly Asp Asp Ala Pro

195 200 205ArgArg Phe Ala Leu Glu His Val Phe Val Asp Asp Asp Ser Thr Leu

210215220 Phe Leu Arg Tyr Lys Arg Ala Lys 225230<210>577<211>578<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(55) } (555)<223>FRXA01712<400>577cttctgttgg cgcttcgcag gtggtcggac gtggtgttgg ttgggtcgag cacg gtg 57

Val

1aag gct gaa aat tat ggt ggc gtg gag gtt tcg cct gaa atc cag aag 105Lys Ala Glu Asn Tyr Gly Gly Val Glu Val Ser Pro Glu Ile Gln Lys

5 10 15caa cgc cag gag ttg ggt cag gaa gcg att ccg ccg att gcg gtg atg 153Gln Arg Gln Glu Leu Gly Gln Glu Ala Ile Pro Pro Ile Ala Val Met

20 25 30tca ggg tcg ttg aat ttt gat gtg gat act cgc ttt ttc ctt gag gcc 201Ser Gly Ser Leu Asn Phe Asp Val Asp Thr Arg Phe Phe Leu Glu Ala

35 40 45gaa gtg ccg ccg atc atc atc acg gat aat tcc gat caa gca aag cag 249Glu Val Pro Pro Ile Ile Ile Thr Asp Asn Ser Asp Gln Ala Lys Gln 50 55 60 65cag cgg ctt gtg gat gct ggg gct cag gtt att gag gtg gag acg ttg 297Gln Arg Leu Val Asp Ala Gly Ala Gln Val Ile Glu Val Glu Thr Leu

70 75 80acg gcg gag gtt ggc gtc gaa aag ctt agg tct ttg ggt tac gcc cgc 345Thr Ala Glu Val Gly Val Glu Lys Leu Arg Ser Leu Gly Tyr Ala Arg

85 90 95att gat tgt gag ggc ggt gca acg ttg tat ggg cag atg ttg gcc gcc 393Ile Asp Cys Glu Gly Gly Ala Thr Leu Tyr Gly Gln Met LeuAla Ala

100 105 110gat ctt gtt gat gtg tgg cat cac acg att gat ccg acg ttg tcg ggc 441Asp Leu Val Asp Val Trp His His Thr Ile Asp Pro Thr Leu Ser Gly

115 120 125agc gtg gag cgc ccc acg gtg aag ggc ggc gat gat gcg ccg cgc cga 489Ser Val Glu Arg Pro Thr Val Lys Gly Gly Asp Asp Ala Pro Arg Arg130 135 140 145ttc gcg ttg gag cac gtc ttt gtc gat gat gac agc acc cta ttc ttg 537Phe Ala Leu Glu His Val Phe Val Asp Asp Asp Ser Thr Leu Phe Leu

150 155 160cgg tat aag cgc gcc aag tgagtgttgg actctccgga tct 578Arg Tyr Lys Arg Ala Lys

165<210>578<211>167<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>578Val Lys Ala Glu Asn Tyr Gly Gly Val Glu Val Ser Pro Glu Ile Gln 151015 Lys Gln Arg Gln Glu Leu Gly Gln Glu Ala Ile Pro Pro Ile Ala Val

20 25 30Met Ser Gly Ser Leu Asn Phe Asp Val Asp Thr Arg Phe Phe Leu Glu

35 40 45Ala Glu Val Pro Pro Ile Ile Ile Thr Asp Asn Ser Asp Gln Ala Lys

50 55 60Gln Gln Arg Leu Val Asp Ala Gly Ala Gln Val Ile Glu Val Glu Thr 65 70 75 80Leu Thr Ala Glu Val Gly Val Glu Lys Leu Arg Ser Leu Gly Tyr Ala

85 90 95Arg Ile Asp Cys Glu Gly Gly Ala Thr Leu Tyr Gly Gln Met Leu Ala

100 105 110Ala Asp Leu Val Asp Val Trp His His Thr Ile Asp Pro Thr Leu Ser

115 120 125Gly Ser Val Glu Arg Pro Thr Val Lys Gly Gly Asp Asp Ala Pro Arg

130 135 140Arg Phe Ala Leu Glu His Val Phe Val Asp Asp Asp Ser Thr Leu Phe145 150 155 160Leu Arg Tyr Lys Arg Ala Lys

165<210>579<211>831<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (808)<223>RXN02384<400>579ctgatgaggc ggatatccgc aacatcgaca gcattgatga actcccacct ttgccagctg 60aatacgagcc tggctacgag gacgattaag aggtagtcct gtg act cgt cgc ctg 115

Val Thr Arg Arg Leu

1 5att ctg ctc cga cac ggg cag act gaa tac aac gcc acg tcc cga atg 163Ile Leu Leu Arg His Gly Gln Thr Glu Tyr Asn Ala Thr Ser Arg Met

10 15 20cag gga caa ttg gac aca gag ctg tct gac ctg ggc ttt caa cag gcg 211Gln Gly Gln Leu Asp Thr Glu Leu Ser Asp Leu Gly Phe Gln Gln Ala

25 30 35gcc agc gca gcc tca gtg ctg gtt caa aaa aac atc acc cat gtg ttc 259Ala Ser Ala Ala Ser Val Leu Val Gln Lys Asn Ile Thr His Val Phe

40 45 50agc tcg gat ctt tcc cgc gcc ttc aac acc gca agc gcg gtt gcg gcg 307Ser Ser Asp Leu Ser Arg Ala Phe Asn Thr Ala Ser Ala Val Ala Ala

55 60 65ctg att gac gcg gag gtg cgc gtc gat aag cgt ctt cgg gaa acg cat 355Leu Ile Asp Ala Glu Val Arg Val Asp Lys Arg Leu Arg Glu Thr His 70 75 80 85ttg ggt gag tgg cag gccaaa acc cac act gag gtg gat tcc gaa tat 403Leu Gly Glu Trp Gln Ala Lys Thr His Thr Glu Val Asp Ser Glu Tyr

90 95 100cca ggt gcg cgc gct caa tgg cgc cac gat ccg cag tgg gca cca ccc 451Pro Gly Ala Arg Ala Gln Trp Arg His Asp Pro Gln Trp Ala Pro Pro

105 110 115ggc ggc gaa tcg cgc gtg gat gtt gcg cgc cgg gca cgc caa gtt gtc 499Gly Gly Glu Ser Arg Val Asp Val Ala Arg Arg Ala Arg Gln Val Val

120 125 130gac gag ttg atg gtg tcg ctt gat gat tgg gat gaa ggc acc gtg ctc 547Asp Glu Leu Met Val Ser Leu Asp Asp Trp Asp Glu Gly Thr Val Leu

135 140 145atc gtg gct cac ggt ggc acg att aat gcg ctg acc tcg aat ctt ttg 595Ile Val Ala His Gly Gly Thr Ile Asn Ala Leu Thr Ser Asn Leu Leu150 155 160 165gac ctg gcg tat gat cag tac ccc atg ttc tct gga ctt gga aat acc 643Asp Leu Ala Tyr Asp Gln Tyr Pro Met Phe Ser Gly Leu Gly Asn Thr

170 175 180tgt tgg gca caa ttg acc gcc cga cct cgc tat tat gca ggt agt gag 691Cys Trp Ala Gln Leu Thr Ala Arg Pro Arg Tyr Tyr Ala Gly Ser Glu

185 190 195aac cca gaa gat gac ctc aag att tct tcg gcg gtt tcc aac agc cct 739Asn Pro Glu Asp Asp Leu Lys Ile Ser Ser Ala Val Ser Asn Ser Pro

200 205 210cat ttt gag ggc aac aat gtg gaa aac gcc cag tgg tat ctt gac ggc 787His Phe Glu G1y Asn Asn Val Glu Asn Ala Gln Trp Tyr Leu Asp Gly

215220225 tgg aac atg ggt gtt acg cag taaagaagat ggcaataaaa atg 831Trp Asn Met Gly Val Thr Gln 230235<210>580<211>236<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>580Val Thr Arg Arg Leu Ile Leu Leu Arg His Gly Gln Thr Glu Tyr Asn 151015 Ala Thr Ser Arg Met Gln Gly Gln Leu Asp Thr Glu Leu Ser Asp Leu

20 25 30Gly Phe Gln Gln Ala Ala Ser Ala Ala Ser Val Leu Val Gln Lys Asn

35 40 45Ile Thr His Val Phe Ser Ser Asp Leu Ser Arg Ala Phe Asn Thr Ala

50 55 60Ser Ala Val Ala Ala Leu Ile Asp Ala Glu Val Arg Val Asp Lys Arg 65 70 75 80Leu Arg Glu Thr His Leu Gly Glu Trp Gln Ala Lys Thr His Thr Glu

85 90 95Val Asp Ser Glu Tyr Pro Gly Ala Arg Ala Gln Trp Arg His Asp Pro

100 105 110Gln Trp Ala Pro Pro Gly Gly Glu Ser Arg Val Asp Val Ala Arg Arg

115 120 125Ala Arg Gln Val Val Asp Glu Leu Met Val Ser Leu Asp Asp Trp Asp

130 135 140Glu Gly Thr Val Leu Ile Val Ala His Gly Gly Thr Ile Asn Ala Leu145 150 155 160Thr Ser Asn Leu Leu Asp Leu Ala Tyr Asp Gln Tyr Pro Met Phe Ser

165 170 175Gly Leu Gly Asn Thr Cys Trp Ala Gln Leu Thr Ala Arg Pro Arg Tyr

180 185 190Tyr Ala Gly Ser Glu Asn Pro Glu Asp Asp Leu Lys Ile Ser Ser Ala

195 200 205Val Ser Asn Ser Pro His Phe Glu Gly Asn Asn Val Glu Asn Ala Gln

210215220 Trp Tyr Leu Asp Gly Trp Asn Met Gly Val Thr Gln 225230235<210>581<211>453<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (430)<223>RXN01560<400>581atgggagcaa ggctcattta gctacttcga cgtggaagcg cacatcgttg agttgattcc 60tgcatcagta agcgatgcgt tttaggcaca tctgcgatcc gtg ggc gtg tcc tac 115

Val Gly Val Ser Tyr

1 5atc atc gcc ggc gat gag cag ctg gat atg gca gaa gcc gtt cgc aaa 163Ile Ile Ala Gly Asp Glu Gln Leu Asp Met Ala Glu Ala Val Arg Lys

10 15 20att ggg gag acc ttt aaa act gag gaa att atc ctt ggt ggc gga gga 211Ile Gly Glu Thr Phe Lys Thr Glu Glu Ile Ile Leu Gly Gly Gly Gly

25 30 35acc ctg aac tgg tcc atg ctc cgc gac ggt ttg tgc gac gag gtt agc 259Thr Leu Asn Trp Ser Met Leu Arg Asp Gly Leu Cys Asp Glu Val Ser

40 45 50atc gtg atg atg cca atc gcc gat ggt gaa aag cac acc cac tct ttg 307Ile Val Met Met Pro Ile Ala Asp Gly Glu Lys His Thr His Ser Leu

55 60 65ttc gaa gcc gat gaa aaa tac tca gca ccg ttg ccg atc ggt ttt tca 355Phe Glu Ala Asp Glu Lys Tyr Ser Ala Pro Leu Pro Ile Gly Phe Ser 70 75 80 85ctc gcc agc gtt gaa cca cta gaa gat gga agc gtt tgg atg cgt tac 403Leu Ala Ser Val Glu Pro Leu Glu Asp Gly Ser Val Trp Met Arg Tyr

90 95 100ggg gtc aat ggc cca gtg gac gcg aac taggtagcaa atactcgctc 450Gly Val Asn Gly Pro Val Asp Ala Asn

105110 ttt 453<210>582<211>110<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>582Val Gly Val Ser Tyr Ile Ile Ala Gly Asp Glu Gln Leu Asp Met Ala 151015 Glu Ala Val Arg Lys Ile Gly Glu Thr Phe Lys Thr Glu Glu Ile Ile

20 25 30Leu Gly Gly Gly Gly Thr Leu Asn Trp Ser Met Leu Arg Asp Gly Leu

35 40 45Cys Asp Glu Val Ser Ile Val Met Met Pro Ile Ala Asp Gly Glu Lys

50 55 60His Thr His Ser Leu Phe Glu Ala Asp Glu Lys Tyr Ser Ala Pro Leu 65 70 75 80Pro Ile Gly Phe Ser Leu Ala Ser Val Glu Pro Leu Glu Asp Gly Ser

85 90 95Val Trp Met Arg Tyr Gly Val Asn Gly Pro Val Asp Ala Asn

100105110<210>583<211>1137<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<1114><223>RXN00667<400>583ggcatcagtg tttgaaggga aaagcaggtc aaacaaggtg cggctgattt gagcgatcac 60agcaccgaga tctgtgctga agaattcaat gattgggttg atg att gcg ttg aag 115

Met Ile Ala Leu Lys

1 5tcc atg tct aac agg gta gta caa aag cca aaa atg aaa gcg ccg cta 163Ser Met Ser Asn Arg Val Val Gln Lys Pro Lys Met Lys Ala Pro Leu

10 15 20ccc atc cgc gac ggc ctc aac cct tcc cgt gtg cgc ttg ccg ctc gac 211Pro Ile Arg Asp Gly Leu Asn Pro Ser Arg Val Arg Leu Pro Leu Asp

2530 35gcg gcg ccg atc cgc gcc atc gat ttt gtt gaa tac ctc att tcc acg 259Ala Ala Pro Ile Arg Ala Ile Asp Phe Val Glu Tyr Leu Ile Ser Thr

40 45 50cag cgc cac cgc aat ccg gcc gac aac gcc gaa gcg ctt caa gcg cgt 307Gln Arg His Arg Asn Pro Ala Asp Asn Ala Glu Ala Leu Gln Ala Arg

55 60 65ttc gac gcc gac ctt gtt gtc aac cac tac ggc gag ccc tac gcc ccc 355Phe Asp Ala Asp Leu Val Val Asn His Tyr Gly Glu Pro Tyr Ala Pro 70 75 80 85gac acc atg gtt cag ccc gac gac gac att tgg ttc tac cgc atg ccc 403Asp Thr Met Val Gln Pro Asp Asp Asp Ile Trp Phe Tyr Arg Met Pro

90 95 100gcc gcc gaa cgg ccg atc cct tac aaa att cat gtc att cac gaa gac 451Ala Ala Glu Arg Pro Ile Pro Tyr Lys Ile His Val Ile His Glu Asp

105 110 115gat gac atc ctc gtc att gac aag cca ccc tac cta gca acc atg cct 499Asp Asp Ile Leu Val Ile Asp Lys Pro Pro Tyr Leu Ala Thr Met Pro

120 125 130cgt ggc cgc cac atc acc gaa acc gct ctg gtg aaa atg cgt gtg ctg 547Arg Gly Arg His Ile Thr Glu Thr Ala Leu Val Lys Met Arg Val Leu

135 140 145act gga aac aac gat ctc acc cca gct cac cgc ctc gat cgc ctg act 595Thr Gly Asn Asn Asp Leu Thr Pro Ala His Arg Leu Asp Arg Leu Thr150 155 160 165tcc ggt gtg tta gtc atg gtg aaa aaa cca gaa ctc cgt ggc gct tac 643Ser Gly Val Leu Val Met Val Lys Lys Pro Glu Leu Arg Gly Ala Tyr

170 175 180caa acc ttg ttt gcc cga cgt gag gcg tcc aaa acc tat gag gca atc 691GlnThr Leu Phe Ala Arg Arg Glu Ala Ser Lys Thr Tyr Glu Ala Ile

185 190 195gca gaa ttc gtt cca ggg cta ctt gat gat ggt ccc gcg att tgg gaa 739Ala Glu Phe Val Pro Gly Leu Leu Asp Asp Gly Pro Ala Ile Trp Glu

200 205 210tcc cgc atc gaa aaa gaa cgc ggc atc gtg caa gcc ttc gtc gtg gaa 787Ser Arg Ile Glu Lys Glu Arg Gly Ile Val Gln Ala Phe Val Val Glu

215 220 225ggc ccc gtc aac gca cgc act gaa ctg gtg tca gtc acc cca gtc gaa 835Gly Pro Val Asn Ala Arg Thr Glu Leu Val Ser Val Thr Pro Val Glu230 235 240 245gac gcc gaa cag agc atc ctc gaa gaa atg cac ggg cca ctc ccc cgc 883Asp Ala Glu Gln Ser Ile Leu Glu Glu Met His Gly Pro Leu Pro Arg

250 255 260caa gcg cgc tac gtt cta gcc ccc tca aca ggc aaa acc cac cag ctg 931Gln Ala Arg Tyr Val Leu Ala Pro Ser Thr Gly Lys Thr His Gln Leu

265 270 275cgc atc cac atg cgc gac ttc gca gcc ccc atc ctc ggc gac ccc ctc 979Arg Ile His Met Arg Asp Phe Ala Ala Pro Ile Leu Gly Asp Pro Leu

280 285 290tac ccc gtc ctc cac gca gtc gac gat gag gac tac acc acc cca atg 1027Tyr Pro Val Leu His Ala Val Asp Asp Glu Asp Tyr Thr Thr Pro Met

295 300 305cac ctc atc gcc cgc acg cta acc ttc gtg gat cct caa acc aac gag 1075His Leu Ile Ala Arg Thr Leu Thr Phe Val Asp Pro Gln Thr Asn Glu310 315 320 325gaa cgt acc ttt gtg agt aat cga cct acg gga agt ttg taggcctcgt 1124Glu Arg Thr Phe Val Ser Asn Arg Pro Thr Gly Ser Leu

330335 agacatcacc cag 1137<210>584<211>338<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>584Met Ile Ala Leu Lys Ser Met Ser Asn Arg Val Val Gln Lys Pro Lys 151015 Met Lys Ala Pro Leu Pro Ile Arg Asp Gly Leu Asn Pro Ser Arg Val

20 25 30Arg Leu Pro Leu Asp Ala Ala Pro Ile Arg Ala Ile Asp Phe Val Glu

35 40 45Tyr Leu Ile Ser Thr Gln Arg His Arg Asn Pro Ala Asp Asn Ala Glu

50 55 60Ala Leu Gln Ala Arg Phe Asp Ala Asp Leu Val Val Asn His Tyr Gly 65 70 75 80Glu Pro Tyr Ala Pro Asp Thr Met Val Gln Pro Asp Asp Asp Ile Trp

85 90 95Phe Tyr Arg Met Pro Ala Ala Glu Arg Pro Ile Pro Tyr Lys Ile His

100 105 110Val Ile His Glu Asp Asp Asp Ile Leu Val Ile Asp Lys Pro Pro Tyr

115 120 125Leu Ala Thr Met Pro Arg Gly Arg His Ile Thr Glu Thr Ala Leu Val

130 135 140Lys Met Arg Val Leu Thr Gly Asn Asn Asp Leu Thr Pro Ala His Arg145 150 155 160Leu Asp Arg Leu Thr Ser Gly Val Leu Val Met Val Lys Lys Pro Glu

165 170 175Leu Arg Gly Ala Tyr Gln Thr Leu Phe Ala Arg Arg Glu Ala Ser Lys

180 185 190Thr Tyr Glu Ala Ile Ala Glu Phe Val Pro Gly Leu Leu Asp Asp Gly

195 200 205Pro Ala Ile Trp Glu Ser Arg Ile Glu Lys Glu Arg Gly Ile Val Gln

210 215 220Ala Phe Val Val Glu Gly Pro Val Asn Ala Arg Thr Glu Leu Val Ser225 230 235 240Val Thr Pro Val Glu Asp Ala Glu Gln Ser Ile Leu Glu Glu Met His

245 250 255Gly Pro Leu Pro Arg Gln Ala Arg Tyr Val Leu Ala Pro Ser Thr Gly

260 265 270Lys Thr His Gln Leu Arg Ile His Met Arg Asp Phe Ala Ala Pro Ile

275 280 285Leu Gly Asp Pro Leu Tyr Pro Val Leu His Ala Val Asp Asp Glu Asp

290 295 300Tyr Thr Thr Pro Met His Leu Ile Ala Arg Thr Leu Thr Phe Val Asp305 310 315 320Pro Gln Thr Asn Glu Glu Arg Thr Phe Val Ser Asn Arg Pro Thr Gly

325330335 Ser Leu<210>585<211>1281<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1258)<223>RXC01711<400>585tctcgtgagt ttctccccgg tagcaccttc tatatcagcc cccacgccgc gtcggagcag 60gtgggatagc atcggcaacg cggttgcatg gccgttggcc atg ttg ttg atg gcg 115

Met Leu Leu Met Ala

1 5cat cgc ttc ttc gtg ctt gcg att aac ggc gca gtc acc gac gat ttc 163His Arg Phe Phe Val Leu Ala Ile Asn Gly Ala Val Thr Asp Asp Phe

10 15 20acg acg gtt tat agt gct tta cga cgt ttc gtt gaa ggt att ccg gtc 211Thr Thr Val Tyr Ser Ala Leu Arg Arg Phe Val Glu Gly Ile Pro Val

25 3035tac aac gag gtc tac cac ttc gtc gat ccg cac tac ctc tat aac ccg 259Tyr Asn Glu Val Tyr His Phe Val Asp Pro His Tyr Leu Tyr Asn Pro

40 45 50ggc gcc acc ctc cta ttg gca cca ttg gga tat atc acc cat ttc acg 307Gly Ala Thr Leu Leu Leu Ala Pro Leu Gly Tyr Ile Thr His Phe Thr

55 60 65ttg gct cgg tgg atg ttc atc gcg gtg aac ctc ctt gcc att gtt tta 355Leu Ala Arg Trp Met Phe Ile Ala Val Asn Leu Leu Ala Ile Val Leu 70 75 80 85gcg ttc ggg ctg ctg acc aga ctc tcc ggt tgg gcg ctg cgc agc atg 403Ala Phe Gly Leu Leu Thr Arg Leu Ser Gly Trp Ala Leu Arg Ser Met

90 95 100gtg tgg ccg att gcg atc gcc ttg gcg atg ctg aca gaa acc gtg caa 451Val Trp Pro Ile Ala Ile Ala Leu Ala Met Leu Thr Glu Thr Val Gln

105 110 115aac acc ctc att ttc tcc aac atc aac ggc atc ctg ctg ctc atg ttg 499Asn Thr Leu Ile Phe Ser Asn Ile Asn Gly Ile Leu Leu Leu Met Leu

120 125 130gcg att ttc ctg tgg tgc gtg gtg cac aaa aaa tcc tgg ttg ggc gga 547Ala Ile Phe Leu Trp Cys Val Val His Lys Lys Ser Trp Leu Gly Gly

135 140 145cta gtc att ggt ttg gcc att ttg atc aaa ccc atg ttc ctg cca ctt 595Leu Val Ile Gly Leu Ala Ile Leu Ile Lys Pro Met Phe Leu Pro Leu150 155 160 165ctc ttc cta cct ttg gtg aaa aag caa tgg gga tcg ctc atc ctc ggc 643Leu Phe Leu Pro Leu Val Lys Lys Gln Trp Gly Ser Leu Ile Leu Gly

170 175 180att tta acc cca gtg att ttc aat gca gtg gcc tgg ttc tta gtt ccg 691Ile Leu Thr Pro Val Ile Phe Asn Ala Val Ala Trp Phe Leu Val Pro

185 190 195gga gca tct gaa tac gtc acc cgc acg atg ccc tac ctt ggt gaa act 739Gly Ala Ser Glu Tyr Val Thr Arg Thr Met Pro Tyr Leu Gly Glu Thr

200 205 210cga gat ttt gcc aac agc tca ctc cca ggc ttg gcc atc tat ttc gga 787Arg Asp Phe Ala Asn Ser Ser Leu Pro Gly Leu Ala Ile Tyr Phe Gly

215 220 225atg ccc acc tgg atg gaa atc acc tgg ttc ctc atc ttc ggc gca atg 835Met Pro Thr Trp Met Glu Ile Thr Trp Phe Leu Ile Phe Gly Ala Met230 235 240 245gtc ggc ctc gca gtg ctg gca ctc ctg aga ttc cgt aac acc gag cca 883Val Gly Leu Ala Val Leu Ala Leu Leu Arg Phe Arg Asn Thr Glu Pro

250 255 260tac ttc tgg gca gca acc acc acc ggt gta ctc ctg act ggc gta ttc 931Tyr Phe Trp Ala Ala Thr Thr Thr Gly Val Leu Leu Thr Gly Val Phe

265 270 275ttc ctg tcc tca ctg gga cag atg tac tac tcc atg atg atc ttc cct 979Phe Leu Ser Ser Leu Gly Gln Met Tyr Tyr Ser Met Met Ile Phe Pro

280 285 290atg atc ttc acc ctg ctc gga agc cga tcc gta ttc cac aac tgg gtt 1027Met Ile Phe Thr Leu Leu Gly Ser Arg Ser Val Phe His Asn Trp Val

295 300 305gcc tgg gtc gcc gcc tac ttc tta cta tcc cct gac act ttc acc tcc 1075Ala Trp Val Ala Ala Tyr Phe Leu Leu Ser Pro Asp Thr Phe Thr Ser310 315 320 325cag cga cta ccc gat gta gcc cgc tgg atg gaa ttt ttc agc gcg acc 1123Gln Arg Leu Pro Asp Val Ala Arg Trp Met Glu Phe Phe Ser Ala Thr

330335 340gtt ggt tgg gga cta ttg ata gtg gtt aca ttt gtc tcg gcg cta atc 1171Val Gly Trp Gly Leu Leu Ile Val Val Thr Phe Val Ser Ala Leu Ile

345 350 355tgg ttt att ggt gat atc cga gcc aag gga act ccg agc tca ccc att 1219Trp Phe Ile Gly Asp Ile Arg Ala Lys Gly Thr Pro Ser Ser Pro Ile

360 365 370acc act gat cca acg cac gac cat ctt gag agg aca gca tgacagactt 1268Thr Thr Asp Pro Thr His Asp His Leu Glu Arg Thr Ala

375380385 caaactcatc agc 1281<210>586<211>386<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>586Met Leu Leu Met Ala His Arg Phe Phe Val Leu Ala Ile Asn Gly Ala 151015 Val Thr Asp Asp Phe Thr Thr Val Tyr Ser Ala Leu Arg Arg Phe Val

20 25 30Glu Gly Ile Pro Val Tyr Asn Glu Val Tyr His Phe Val Asp Pro His

35 40 45Tyr Leu Tyr Asn Pro Gly Ala Thr Leu Leu Leu Ala Pro Leu Gly Tyr

50 55 60Ile Thr His Phe Thr Leu Ala Arg Trp Met Phe Ile Ala Val Asn Leu 65 70 75 80Leu Ala Ile Val Leu Ala Phe Gly Leu Leu Thr Arg Leu Ser Gly Trp

85 90 95Ala Leu Arg Ser Met Val Trp Pro Ile Ala Ile Ala Leu Ala Met Leu

100 105 110Thr Glu Thr Val Gln Asn Thr Leu Ile Phe Ser Asn Ile Asn Gly Ile

115 120 125Leu Leu Leu Met Leu Ala Ile Phe Leu Trp Cys Val Val His Lys Lys

130 135140Ser Trp Leu Gly Gly Leu Val Ile Gly Leu Ala Ile Leu Ile Lys Pro145 150 155 160Met Phe Leu Pro Leu Leu Phe Leu Pro Leu Val Lys Lys Gln Trp Gly

165 170 175Ser Leu Ile Leu Gly Ile Leu Thr Pro Val Ile Phe Asn Ala Val Ala

180 185 190Trp Phe Leu Val Pro Gly Ala Ser Glu Tyr Val Thr Arg Thr Met Pro

195 200 205Tyr Leu Gly Glu Thr Arg Asp Phe Ala Asn Ser Ser Leu Pro Gly Leu

210 215 220Ala Ile Tyr Phe Gly Met Pro Thr Trp Met Glu Ile Thr Trp Phe Leu225 230 235 240Ile Phe Gly Ala Met Val Gly Leu Ala Val Leu Ala Leu Leu Arg Phe

245 250 255Arg Asn Thr Glu Pro Tyr Phe Trp Ala Ala Thr Thr Thr Gly Val Leu

260 265 270Leu Thr Gly Val Phe Phe Leu Ser Ser Leu Gly Gln Met Tyr Tyr Ser

275 280 285Met Met Ile Phe Pro Met Ile Phe Thr Leu Leu Gly Ser Arg Ser Val

290 295 300Phe His Asn Trp Val Ala Trp Val Ala Ala Tyr Phe Leu Leu Ser Pro305 310 315 320Asp Thr Phe Thr Ser Gln Arg Leu Pro Asp Val Ala Arg Trp Met Glu

325 330 335Phe Phe Ser Ala Thr Val Gly Trp Gly Leu Leu Ile Val Val Thr Phe

340 345 350Val Ser Ala Leu Ile Trp Phe Ile Gly Asp Ile Arg Ala Lys Gly Thr

355 360 365Pro Ser Ser Pro Ile Thr Thr Asp Pro Thr His Asp His Leu Glu Arg

370375380 Thr Ala385<210>587<211>777<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (754)<223>RXC02380<400>587gcagattttt gacgaagtcg catcgtggat tgaagctgcc taaaaactcg cgaggacgca 60tgctcagcaa ggtggtgtgc gaacactata ctgtccactc atg act aca acg gtg 115

Met Thr Thr Thr Val

1 5aaa cgc cgc gct cgc att ggc atc atg ggt ggc aca ttt gac ccc att 163Lys Arg Arg Ala Arg Ile Gly Ile Met Gly Gly Thr Phe Asp Pro Ile

10 15 20cat aat ggt cac ctt gtg gcg ggc tca gag gta gcg gat cga ttc gat 211His Asn Gly His Leu Val Ala Gly Ser Glu Val Ala Asp Arg Phe Asp

25 30 35ctt gat ctg gtg gtg tac gtt ccc acc gga cag cca tgg caa aag gcg 259Leu Asp Leu Val Val Tyr Val Pro Thr Gly Gln Pro Trp Gln Lys Ala

40 45 50aac aag aaa gtc agc cca gcg gaa gat cgt tac ctg atg acg gtg atc 307Asn Lys Lys Val Ser Pro Ala Glu Asp Arg Tyr Leu Met Thr Val Ile

55 60 65gcc act gcc tct aat cca cgg ttt atg gta tcg cgg gtt gat att gat 355Ala Thr Ala Ser Asn Pro Arg Phe Met Val Ser Arg Val Asp Ile Asp 70 75 80 85cgg gga ggg gat act tac acg atc gat acc ctg caa gat ttg agc aag 403Arg Gly Gly Asp Thr Tyr Thr Ile Asp Thr Leu Gln Asp Leu Ser Lys

90 95 100caa tac ccg gac gcc cag ctg tac ttc atc acc ggt gcc gat gca ctg 451Gln Tyr Pro Asp Ala Gln Leu Tyr Phe Ile Thr Gly Ala Asp Ala Leu

105 110 115gca cag atc gtg acg tgg cgc gat tgg gag aaa acc ttc gaa ctt gcc 499Ala Gln Ile Val Thr Trp Arg Asp Trp Glu Lys Thr Phe Glu Leu Ala

120 125 130cac ttc gtt gga gtg act cga ccc ggt tat gaa ttg gat gga aac atc 547His Phe Val Gly Val Thr Arg Pro Gly Tyr Glu Leu Asp Gly Asn Ile

135 140 145att ccg gaa atg cac caa gat cga gtc tca ttg gtg gat atc ccc gcc 595Ile Pro Glu Met His Gln Asp Arg Val Ser Leu Val Asp Ile Pro Ala150 155 160 165atg gct att tcc tcc acg gac tgc aga gaa cgc tcc agc gaa gaa cgc 643Met Ala Ile Ser Ser Thr Asp Cys Arg Glu Arg Ser Ser Glu Glu Arg

170 175 180cct gtt tgg tat ctt gtc cct gat ggc gtg gtg caa tac att gcc aaa 691Pro Val Trp Tyr Leu Val Pro Asp Gly Val Val Gln Tyr Ile Ala Lys

185 190 195cgc caa ctc tat cga cct gaa gga tcc gat aag gat atg gat ccc aag 739Arg Gln Leu Tyr Arg Pro Glu Gly Ser Asp Lys Asp Met Asp Pro Lys

200 205 210ggc caa aac caa gca taaatctagt caaaagtttc aac 777Gly Gln Asn Gln Ala

215<210>588<211>218<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>588Met Thr Thr Thr Val Lys Arg Arg Ala Arg Ile Gly Ile Met Gly Gly 151015 Thr Phe Asp Pro Ile His Asn Gly His Leu Val Ala Gly Ser Glu Val

20 25 30Ala Asp Arg Phe Asp Leu Asp Leu Val Val Tyr Val Pro Thr Gly Gln

35 40 45Pro Trp Gln Lys Ala Asn Lys Lys Val Ser Pro Ala Glu Asp Arg Tyr

50 55 60Leu Met Thr Val Ile Ala Thr Ala Ser Asn Pro Arg Phe Met Val Ser 65 70 75 80Arg Val Asp Ile Asp Arg Gly Gly Asp Thr Tyr Thr Ile Asp Thr Leu

85 90 95Gln Asp Leu Ser Lys Gln Tyr Pro Asp Ala Gln Leu Tyr Phe Ile Thr

100 105 110Gly Ala Asp Ala Leu Ala Gln Ile Val Thr Trp Arg Asp Trp Glu Lys

115 120 125Thr Phe Glu Leu Ala His Phe Val Gly Val Thr Arg Pro Gly Tyr Glu

130 135 140Leu Asp Gly Asn Ile Ile Pro Glu Met His Gln Asp Arg Val Ser Leu145 150 155 160Val Asp Ile Pro Ala Met Ala Ile Ser Ser Thr Asp Cys Arg Glu Arg

165 170 175Ser Ser Glu Glu Arg Pro Val Trp Tyr Leu Val Pro Asp Gly Val Val

180 185 190Gln Tyr Ile Ala Lys Arg Gln Leu Tyr Arg Pro Glu Gly Ser Asp Lys

195 200 205Asp Met Asp Pro Lys Gly Gln Asn Gln Ala

210215<210>589<211>777<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220>CDS<222>(101).<754>FRXA02380<400>589gcagattttt gacgaagtcg catcgtggat tgaagctgcc taaaaactcg cgaggacgca 60tgctcagcaa ggtggtgtgc gaacactata ctgtccactc atg act aca acg gtg 115

Met Thr Thr Thr Val

1 5aaa cgc cgc gct cgc att ggc atc atg ggt ggc aca ttt gac ccc att 163Lys Arg Arg Ala Arg Ile Gly Ile Met Gly Gly Thr Phe Asp Pro Ile

10 15 20cat aat ggt cac ctt gtg gcg ggc tca gag gta gcg gat cga ttc gat 211His Asn Gly His Leu Val Ala Gly Ser Glu Val Ala Asp Arg Phe Asp

25 30 35ctt gat ctg gtg gtg tac gtt ccc acc gga cag cca tgg caa aag gcg 259Leu Asp Leu Val Val Tyr Val Pro Thr Gly Gln Pro Trp Gln Lys Ala

40 45 50aac aag aaa gtc agc cca gcg gaa gat cgt tac ctg atg acg gtg atc 307Asn Lys Lys Val Ser Pro Ala Glu Asp Arg Tyr Leu Met Thr Val Ile

55 60 65gcc act gcc tct aat cca cgg ttt atg gta tcg cgg gtt gat att gat 355Ala Thr Ala Ser Asn Pro Arg Phe Met Val Ser Arg Val Asp Ile Asp 70 75 80 85cgg gga ggg gat act tac acg atc gat acc ctg caa gat ttg agc aag 403Arg Gly Gly Asp Thr Tyr Thr Ile Asp Thr Leu Gln Asp Leu Ser Lys

90 95 100caa tac ccg gac gcc cag ctg tac ttc atc acc ggt gcc gat gca ctg 451Gln Tyr Pro Asp Ala Gln Leu Tyr Phe Ile Thr Gly Ala Asp Ala Leu

105 110 115gca cag atc gtg acg tgg cgc gat tgg gag aaa acc ttc gaa ctt gcc 499Ala Gln Ile Val Thr Trp Arg Asp Trp Glu Lys Thr Phe Glu Leu Ala

120 125 130cac ttc gtt gga gtg act cga ccc ggt tat gaa ttg gat gga aac atc 547His Phe Val Gly Val Thr Arg Pro Gly Tyr Glu Leu Asp Gly Asn Ile

135 140145att ccg gaa atg cac caa gat cga gtc tca ttg gtg gat atc ccc gcc 595Ile Pro Glu Met His Gln Asp Arg Val Ser Leu Val Asp Ile Pro Ala150 155 160 165atg gct att tcc tcc acg gac tgc aga gaa cgc tcc agc gaa gaa cgc 643Met Ala Ile Ser Ser Thr Asp Cys Arg Glu Arg Ser Ser Glu Glu Arg

170 175 180cct gtt tgg tat ctt gtc cct gat ggc gtg gtg caa tac att gcc aaa 691Pro Val Trp Tyr Leu Val Pro Asp Gly Val Val Gln Tyr Ile Ala Lys

185 190 195cgc caa ctc tat cga cct gaa gga tcc gat aag gat atg gat ccc aag 739Arg Gln Leu Tyr Arg Pro Glu Gly Ser Asp Lys Asp Met Asp Pro Lys

200 205 210ggc caa aac caa gca taaatctagt caaaagtttc aac 777Gly Gln Asn Gln Ala

215<210>590<211>218<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>590Met Thr Thr Thr Val Lys Arg Arg Ala Arg Ile Gly Ile Met Gly Gly 151015 Thr Phe Asp Pro Ile His Asn Gly His Leu Val Ala Gly Ser Glu Val

20 25 30Ala Asp Arg Phe Asp Leu Asp Leu Val Val Tyr Val Pro Thr Gly Gln

35 40 45Pro Trp Gln Lys Ala Asn Lys Lys Val Ser Pro Ala Glu Asp Arg Tyr

50 55 60Leu Met Thr Val Ile Ala Thr Ala Ser Asn Pro Arg Phe Met Val Ser 65 70 75 80Arg Val Asp Ile Asp Arg Gly Gly Asp Thr Tyr Thr Ile Asp Thr Leu

85 90 95Gln Asp Leu Ser Lys Gln Tyr Pro Asp Ala Gln Leu Tyr Phe Ile Thr

100 105 110Gly Ala Asp Ala Leu Ala Gln Ile Val Thr Trp Arg Asp Trp Glu Lys

115 120 125Thr Phe Glu Leu Ala His Phe Val Gly Val Thr Arg Pro Gly Tyr Glu

130 135 140Leu Asp Gly Asn Ile Ile Pro Glu Met His Gln Asp Arg Val Ser Leu145 150 155 160Val Asp Ile Pro Ala Met Ala Ile Ser Ser Thr Asp Cys Arg Glu Arg

165 170 175Ser Ser Glu Glu Arg Pro Val Trp Tyr Leu Val Pro Asp Gly Val Val

180 185 190Gln Tyr Ile Ala Lys Arg Gln Leu Tyr Arg Pro Glu Gly Ser Asp Lys

195 200 205Asp Met Asp Pro Lys Gly Gln Asn Gln Ala

210215<210>591<211>594<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CPS<222>(101). (571)<223>RXC02921<400>591tggaaaactg ggaagggttg acgttgcgga atctctccgc agcgtcggtt cggaccctaa 60aaaagggtga ggaaccacat gagctgtttt aaggaatttt gtg tct gca ctt gaa 115

Val Ser Ala Leu Glu

1 5gag tcg atc cgc atc gcg acc atc gcg gcg aaa gca gcg gat gaa aag 163Glu Ser Ile Arg Ile Ala Thr Ile Ala Ala Lys Ala Ala Asp Glu Lys

10 15 20aag gcc gat gac atc gct gtc atc gat gtc tct gac atg atc gca atc 211Lys Ala Asp Asp Ile Ala Val Ile Asp Val Ser Asp Met Ile Ala Ile

25 30 35acc gat tgc ttt gtt gttgca tct gct gac aat gag cgc cag gtg ggc 259Thr Asp Cys Phe Val Val Ala Ser Ala Asp Asn Glu Arg Gln Val Gly

40 45 50gcc att gtt gag gag atc gaa gat gag atg acc aag gct ggt ttc gag 307Ala Ile Val Glu Glu Ile Glu Asp Glu Met Thr Lys Ala Gly Phe Glu

55 60 65cct aag cgc cgt gaa ggc aac cgc gaa aac cgt tgg gtt ctc ctt gac 355Pro Lys Arg Arg Glu Gly Asn Arg Glu Asn Arg Trp Val Leu Leu Asp 70 75 80 85tac gga ttg gtt gtt atc cac gtt cag cga cag gca gag cgc gag ttc 403Tyr Gly Leu Val Val Ile His Val Gln Arg Gln Ala Glu Arg Glu Phe

90 95 100tac gga ctg gat cgt ctg tac cgc gac tgc cca ctc att gaa att gaa 451Tyr Gly Leu Asp Arg Leu Tyr Arg Asp Cys Pro Leu Ile Glu Ile Glu

105 110 115gga ctt gaa acc ttc aag cgt gaa tcc tcc tgg tct gat gag gcg gat 499Gly Leu Glu Thr Phe Lys Arg Glu Ser Ser Trp Ser Asp Glu Ala Asp

120 125 130atc cgc aac atc gac agc att gat gaa ctc cca cct ttg cca gct gaa 547Ile Arg Asn Ile Asp Ser Ile Asp Glu Leu Pro Pro Leu Pro Ala Glu

135140145 tac gag cct ggc tac gag gac gat taagaggtag tcctgtgact cgt 594Tyr Glu Pro Gly Tyr Glu Asp Asp 150155<210>592<211>157<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>592Val Ser Ala Leu Glu Glu Ser Ile Arg Ile Ala Thr Ile Ala Ala Lys 151015 Ala Ala Asp Glu Lys Lys Ala Asp Asp Ile Ala Val Ile Asp Val Ser

20 25 30Asp Met Ile Ala Ile Thr Asp Cys Phe Val Val Ala Ser Ala Asp Asn

35 4045Glu Arg Gln Val Gly Ala Ile Val Glu Glu Ile Glu Asp Glu Met Thr

50 55 60Lys Ala Gly Phe Glu Pro Lys Arg Arg Glu Gly Asn Arg Glu Asn Arg 65 70 75 80Trp Val Leu Leu Asp Tyr Gly Leu Val Val Ile His Val Gln Arg Gln

85 90 95Ala Glu Arg Glu Phe Tyr Gly Leu Asp Arg Leu Tyr Arg Asp Cys Pro

100 105 110Leu Ile Glu Ile Glu Gly Leu Glu Thr Phe Lys Arg Glu Ser Ser Trp

115 120 125Ser Asp Glu Ala Asp Ile Arg Asn Ile Asp Ser Ile Asp Glu Leu Pro

130135140 Pro Leu Pro Ala Glu Tyr Glu Pro Gly Tyr Glu Asp Asp 145150155<210>593<211>3075<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (3052)<223>RXC01434<400>593ggtttcctgc gcaccgtgat gattggtgcg gcgctgtcgc cggccatcgc ttcggcgttc 60aacactgcca acacgctgcc caacctgatc actggaaatc gtg ttg ggt gcg gtg 115

Val Leu Gly Ala Val

1 5ctg aca tcg ctg gtt att ccg gtc ctt acc cgc gcg gaa aaa gaa gac 163Leu Thr Ser Leu Val Ile Pro Val Leu Thr Arg Ala Glu Lys Glu Asp

10 15 20gcc gac ggc ggt tcc ggg ttc ttc agg cgg ctg ctc acc ctg tcg gtg 211Ala Asp Gly Gly Ser Gly Phe Phe Arg Arg Leu Leu Thr Leu Ser Val

25 30 35acg ctg ctg ggt ggt gtc acc atc ctg tcg att atc ggc gcg ccg ctg 259Thr Leu Leu Gly Gly Val Thr Ile Leu Ser Ile Ile Gly AlaPro Leu

40 45 50ctg aca cgg atg atg ctg tcc tct gag gga caa gtc aac gtg gtc atg 307Leu Thr Arg Met Met Leu Ser Ser Glu Gly Gln Val Asn Val Val Met

55 60 65tcc acg gcc ttt gcg tat tgg ctg ctg cca cag att ttc ttc tac ggc 355Ser Thr Ala Phe Ala Tyr Trp Leu Leu Pro Gln Ile Phe Phe Tyr Gly 70 75 80 85ctg ttt gcc ctg ttc atg gct gtg ttg aac acc cgt gaa gtg ttc aaa 403Leu Phe Ala Leu Phe Met Ala Val Leu Asn Thr Arg Glu Val Phe Lys

90 95 100ccc ggc gcg tgg gca cct gtt gtc aac aat gtg atc acc ttg acc gtg 451Pro Gly Ala Trp Ala Pro Val Val Asn Asn Val Ile Thr Leu Thr Val

105 110 115ctg ggc gtg tac atg gtg ctg cct gcg cgt ttg cac ccg cat gag cag 499Leu Gly Val Tyr Met Val Leu Pro Ala Arg Leu His Pro His Glu Gln

120 125 130gtg ggc att ttt gat ccg cag atc att ttc ctc ggc gtg ggc acc acc 547Val Gly Ile Phe Asp Pro Gln Ile Ile Phe Leu Gly Val Gly Thr Thr

135 140 145ctt ggt gtg gtt gca cag tgt cta atc atg att ccg tac ctg cgt cgc 595Leu Gly Val Val Ala Gln Cys Leu Ile Met Ile Pro Tyr Leu Arg Arg150 155 160 165gcg ggc att gat atg cgc cct ctg tgg ggt atc gat gcg cgt ttg aag 643Ala Gly Ile Asp Met Arg Pro Leu Trp Gly Ile Asp Ala Arg Leu Lys

170 175 180caa ttc ggt ggc atg gcg atg gcg atc atc gtg tac gtg gca atc tcc 691Gln Phe Gly Gly Met Ala Met Ala Ile Ile Val Tyr Val Ala Ile Ser

185 190 195cag ttc ggt tac atc atc acc act cgc att gcg tcg att gca gac gat 739Gln Phe Gly Tyr Ile Ile Thr Thr Arg Ile Ala Ser Ile Ala Asp Asp

200 205 210gct gcg ccg ttt att tat cag cag cac tgg atg ttg ctg caa gtt cct 787Ala Ala Pro Phe Ile Tyr Gln Gln His Trp Met Leu Leu Gln Val Pro

215 220 225tat ggc atc atc ggc gtc acc ttg ctc acc gcg att atg ccg cga ctg 835Tyr Gly Ile Ile Gly Val Thr Leu Leu Thr Ala Ile Met Pro Arg Leu230 235 240 245tcc cgc aac gcg gca gac ggc gat gat agg gca gta gtc tct gac ctt 883Ser Arg Asn Ala Ala Asp Gly Asp Asp Arg Ala Val Val Ser Asp Leu

250 255 260cag ttg ggt tcc aag cta acc ttc atc gca ctg atc ccc atc gtg gtg 931Gln Leu Gly Ser Lys Leu Thr Phe Ile Ala Leu Ile Pro Ile Val Val

265 270 275ttc ttc acc gcc ttc ggt gtc cct att gcc aat ggc ctt ttt gcc tac 979Phe Phe Thr Ala Phe Gly Val Pro Ile Ala Asn Gly Leu Phe Ala Tyr

280 285 290ggc caa ttc gat gcc aac gcc gcc aac atc ctt ggt tgg act ctg agc 1027Gly Gln Phe Asp Ala Asn Ala Ala Asn Ile Leu Gly Trp Thr Leu Ser

295 300 305ttc tct gct ttc acg ctg att cct tac gct ttg gtg ctg cta cat ctg 1075Phe Ser Ala Phe Thr Leu Ile Pro Tyr Ala Leu Val Leu Leu His Leu310 315 320 325cgt gtg ttt tat gcg cgt gaa gag gtc tgg acc cca acc ttc atc atc 1123Arg Val Phe Tyr Ala Arg Glu Glu Val Trp Thr Pro Thr Phe Ile Ile

330 335 340gcc ggc atc acc gcc acc aag gtc gtg ctt tcc ctg ttg gca ccg ctg 1171Ala Gly Ile Thr Ala Thr Lys Val Val Leu Ser Leu Leu Ala Pro Leu

345 350 355ctg tcg agc tcc ccg gag cgt gtg gtg gtg ctt ctt ggt gcg gcc aac 1219Leu Ser Ser Ser Pro Glu Arg Val Val Val Leu Leu Gly Ala Ala Asn

360 365 370ggt ttc agt ttc atc acc ggc gcg gtc atc ggc gcg tat ctg ttg cgc 1267Gly Phe Ser Phe Ile Thr Gly Ala Val Ile Gly Ala Tyr Leu Leu Arg

375 380 385aac aaa ctc ggc ctg ttg ggt atg cgc tct ttg gct aaa acc tcc ctg 1315Asn Lys Leu Gly Leu Leu Gly Met Arg Ser Leu Ala Lys Thr Ser Leu390 395 400 405tgg gcg ttg ggc tct gcg gcg gtt ggt gca gca gca gca tgg gcg ttg 1363Trp Ala Leu Gly Ser Ala Ala Val Gly Ala Ala Ala Ala Trp Ala Leu

410 415 420ggg tgg ctg att caa gcc gtc gtg ggc gat ttc ttg ctg ggc act cta 1411Gly Trp Leu Ile Gln Ala Val Val Gly Asp Phe Leu Leu Gly Thr Leu

425 430 435agc tcc gta ggc tac ttg ttg aac ctg gct gtg ttg ggt gtc ttc ttc 1459Ser Ser Val Gly Tyr Leu Leu Asn Leu Ala Val Leu Gly Val Phe Phe

440 445 450atc ttc gtc acc ggc atc gtg ttg tca cgt tct ggt ttg ccg gag gtc 1507Ile Phe Val Thr Gly Ile Val Leu Ser Arg Ser Gly Leu Pro Glu Val

455 460 465caa aac ttg ggc cag gca ctg acc cgc atc cca ggt ttg agc cgg ttt 1555Gln Asn Leu Gly Gln Ala Leu Thr Arg Ile Pro Gly Leu Ser Arg Phe470 475 480 485att cgc ccg aat acc aag atc tct ttg gat gtc ggc gaa gtc tcc gag 1603Ile Arg Pro Asn Thr Lys Ile Ser Leu Asp Val Gly Glu Val Ser Glu

490495 500cag gat ttc tcc acc cag ctg gtc gcg cca agc gag ttc gca gca acc 1651Gln Asp Phe Ser Thr Gln Leu Val Ala Pro Ser Glu Phe Ala Ala Thr

505 510 515cct gtg ccg cca ccg atg tcc gcc ggt att gtc cgc gga cct cgc ctg 1699Pro Val Pro Pro Pro Met Ser Ala Gly Ile Val Arg Gly Pro Arg Leu

520 525 530gtt ccc ggc gcc cca gtc ggc gac ggt cgt ttc cgt ctg ctc gcc gat 1747Val Pro Gly Ala Pro Val Gly Asp Gly Arg Phe Arg Leu Leu Ala Asp

535 540 545cac ggc ggc gtc caa ggc gcg cgt ttc tgg cag gcc cgc gag atc gcc 1795His Gly Gly Val Gln Gly Ala Arg Phe Trp Gln Ala Arg Glu Ile Ala550 555 560 565acc ggc aag gaa gtc gcg ctg atc ttt gtg gat act tcc ggc aac gcc 1843Thr Gly Lys Glu Val Ala Leu Ile Phe Val Asp Thr Ser Gly Asn Ala

570 575 580cca ttt gcg cca ctg tct tcg gca gcc gca gcg ggc atc gcc tac gag 1891Pro Phe Ala Pro Leu Ser Ser Ala Ala Ala Ala Gly Ile Ala Tyr Glu

585 590 595gtg cag cgc cgc acc aag aag ctg gcc agc ttg ggc agc ttg gcg gta 1939Val Gln Arg Arg Thr Lys Lys Leu Ala Ser Leu Gly Ser Leu Ala Val

600 605 610gcc ccc aac atc cac tcc gag gcg tac cgc aac ggt tgc ctc att gtg 1987Ala Pro Asn Ile His Ser Glu Ala Tyr Arg Asn Gly Cys Leu Ile Val

615 620 625gcc gat tgg gtg cct ggc tcc agc ttg agc gcc gtc gcg gaa tcc ggt 2035Ala Asp Trp Val Pro Gly Ser Ser Leu Ser Ala Val Ala Glu Ser Gly630 635 640 645gcc gat ccc cgc gcc gcc gcg ttc gcg ctc gcg gaa cta act gaa acc 2083Ala Asp Pro Arg Ala Ala Ala Phe Ala Leu Ala Glu Leu Thr Glu Thr

650 655 660atc ggc gag gcc cac gag atg ggt atc ccg gcc ggc ttg gac aac aag 2131Ile Gly Glu Ala His Glu Met Gly Ile Pro Ala Gly Leu Asp Asn Lys

665 670 675tgc cga att cgt atc aac acc gac ggc cat gcc gtc ctc gcc ttg ccg 2179Cys Arg Ile Arg Ile Asn Thr Asp Gly His Ala Val Leu Ala Leu Pro

680 685 690gcg att ttg ccc gat gcc tca gag ctc cgc gac gcc aag tcc ctg gcc 2227Ala Ile Leu Pro Asp Ala Ser Glu Leu Arg Asp Ala Lys Ser Leu Ala

695 700 705tcg gcc gcc gag atg ctt atc gac gcg acc ctc gct ccc agc gac gtc 2275Ser Ala Ala Glu Met Leu Ile Asp Ala Thr Leu Ala Pro Ser Asp Val710 715 720 725aag gca atg gtc act gaa gcc cag ggg cta gct aca gaa gac aat ccc 2323Lys Ala Met Val Thr Glu Ala Gln Gly Leu Ala Thr Glu Asp Asn Pro

730 735 740gat tac gca tca ctt gcc atg gcg atg cgc acc tgc gga ctg ttc acc 2371Asp Tyr Ala Ser Leu Ala Met Ala Met Arg Thr Cys Gly Leu Phe Thr

745 750 755gag gaa cca acc cac ctt gtg gtg aag aag gaa aag aca cca aag cct 2419Glu Glu Pro Thr His Leu Val Val Lys Lys Glu Lys Thr Pro Lys Pro

760 765 770gcg aca cgt gat ggt ttc ggt gcc tcc gac tac acc gtc aag ggc atg 2467Ala Thr Arg Asp Gly Phe Gly Ala Ser Asp Tyr Thr Val Lys Gly Met

775 780 785gca gcc atc gcc gct gtg gtg atc atc ttg gtt tcc ctg gtg gcc gcc 2515Ala Ala Ile Ala Ala Val Val Ile Ile Leu Val Ser Leu Val Ala Ala790 795800 805ggt acc gcg ttc ctc acc agc ttc ttc ggc agc agc acc aac gaa caa 2563Gly Thr Ala Phe Leu Thr Ser Phe Phe Gly Ser Ser Thr Asn Glu Gln

810 815 820tcc ccg ttg gcc tct gtt gaa gcc acc acc tct gca aca cca gaa cct 2611Ser Pro Leu Ala Ser Val Glu Ala Thr Thr Ser Ala Thr Pro Glu Pro

825 830 835gtg ggg cca ccg gtc tac ctg gat ctg gat caa gcc cgc acg tgg gat 2659Val Gly Pro Pro Val Tyr Leu Asp Leu Asp Gln Ala Arg Thr Trp Asp

840 845 850gac ggt gca gga aca gat gtc acc gac gtc acc gac ggc aac acc tcc 2707Asp Gly Ala Gly Thr Asp Val Thr Asp Val Thr Asp Gly Asn Thr Ser

855 860 865acc gca tgg acc tcc acc ggc ggc gac ggc ctc cta gtt gac ctg tcc 2755Thr Ala Trp Thr Ser Thr Gly Gly Asp Gly Leu Leu Val Asp Leu Ser870 875 880 885acg cct gcc cgc ctc gac cgc gtc atc ttg acc acc ggc acc ggc tcc 2803Thr Pro Ala Arg Leu Asp Arg Val Ile Leu Thr Thr Gly Thr Gly Ser

890 895 900gac agc aac gtg acc tcg acc gtg aag atc tac gca ttc aac gac gcc 2851Asp Ser Asn Val Thr Ser Thr Val Lys Ile Tyr Ala Phe Asn Asp Ala

905 910 915tca cca cac tcc ctg tcg gaa ggc atc gag atc ggc acc gtg gat tat 2899Ser Pro His Ser Leu Ser Glu Gly Ile Glu Ile Gly Thr Val Asp Tyr

920 925 930tcc ggc cgc agt ctc agc cac agc atc cgc gat tcc tcc aag ctt ccg 2947Ser Gly Arg Ser Leu Ser His Ser Ile Arg Asp Ser Ser Lys Leu Pro

935 940 945ggt cag gtg gaa tcc gtg gtg attctg gtc gat gag gtt cgt tcc tca 2995Gly Gln Val Glu Ser Val Val Ile Leu Val Asp Glu Val Arg Ser Ser950 955 960 965caa acc tca gac acc aat cca cag atg cag atc gct gaa gta caa ctt 3043Gln Thr Ser Asp Thr Asn Pro Gln Met Gln Ile Ala Glu Val Gln Leu

970975980 gtt ggt tgg taaattacgc gtttgtgatt gac 3075Val Gly Trp<210>594<211>984<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>594Val Leu Gly Ala Val Leu Thr Ser Leu Val Ile Pro Val Leu Thr Arg 151015 Ala Glu Lys Glu Asp Ala Asp Gly Gly Ser Gly Phe Phe Arg Arg Leu

20 25 30Leu Thr Leu Ser Val Thr Leu Leu Gly Gly Val Thr Ile Leu Ser Ile

35 40 45Ile Gly Ala Pro Leu Leu Thr Arg Met Met Leu Ser Ser Glu Gly Gln

50 55 60Val Asn Val Val Met Ser Thr Ala Phe Ala Tyr Trp Leu Leu Pro Gln 65 70 75 80Ile Phe Phe Tyr Gly Leu Phe Ala Leu Phe Met Ala Val Leu Asn Thr

85 90 95Arg Glu Val Phe Lys Pro Gly Ala Trp Ala Pro Val Val Asn Asn Val

100 105 110Ile Thr Leu Thr Val Leu Gly Val Tyr Met Val Leu Pro Ala Arg Leu

115 120 125His Pro His Glu Gln Val Gly Ile Phe Asp Pro Gln Ile Ile Phe Leu

130 135 140Gly Val Gly Thr Thr Leu Gly Val Val Ala Gln Cys Leu Ile Met Ile145 150 155 160Pro Tyr Leu Arg Arg Ala Gly Ile Asp Met Arg Pro Leu Trp Gly Ile

165170 175Asp Ala Arg Leu Lys Gln Phe Gly Gly Met Ala Met Ala Ile Ile Val

180 185 190Tyr Val Ala Ile Ser Gln Phe Gly Tyr Ile Ile Thr Thr Arg Ile Ala

195 200 205Ser Ile Ala Asp Asp Ala Ala Pro Phe Ile Tyr Gln Gln His Trp Met

210 215 220Leu Leu Gln Val Pro Tyr Gly Ile Ile Gly Val Thr Leu Leu Thr Ala225 230 235 240Ile Met Pro Arg Leu Ser Arg Asn Ala Ala Asp Gly Asp Asp Arg Ala

245 250 255Val Val Ser Asp Leu Gln Leu Gly Ser Lys Leu Thr Phe Ile Ala Leu

260 265 270Ile Pro Ile Val Val Phe Phe Thr Ala Phe Gly Val Pro Ile Ala Asn

275 280 285Gly Leu Phe Ala Tyr Gly Gln Phe Asp Ala Asn Ala Ala Asn Ile Leu

290 295 300Gly Trp Thr Leu Ser Phe Ser Ala Phe Thr Leu Ile Pro Tyr Ala Leu305 310 315 320Val Leu Leu His Leu Arg Val Phe Tyr Ala Arg Glu Glu Val Trp Thr

325 330 335Pro Thr Phe Ile Ile Ala Gly Ile Thr Ala Thr Lys Val Val Leu Ser

340 345 350Leu Leu Ala Pro Leu Leu Ser Ser Ser Pro Glu Arg Val Val Val Leu

355 360 365Leu Gly Ala Ala Asn Gly Phe Ser Phe Ile Thr Gly Ala Val Ile Gly

370 375 380Ala Tyr Leu Leu Arg Asn Lys Leu Gly Leu Leu Gly Met Arg Ser Leu385 390395 400Ala Lys Thr Ser Leu Trp Ala Leu Gly Ser Ala Ala Val Gly Ala Ala

405 410 415Ala Ala Trp Ala Leu Gly Trp Leu Ile Gln Ala Val Val Gly Asp Phe

420 425 430Leu Leu Gly Thr Leu Ser Ser Val Gly Tyr Leu Leu Asn Leu Ala Val

435 440 445Leu Gly Val Phe Phe Ile Phe Val Thr Gly Ile Val Leu Ser Arg Ser

450 455 460Gly Leu Pro Glu Val Gln Asn Leu Gly Gln Ala Leu Thr Arg Ile Pro465 470 475 480Gly Leu Ser Arg Phe Ile Arg Pro Asn Thr Lys Ile Ser Leu Asp Val

485 490 495Gly Glu Val Ser Glu Gln Asp Phe Ser Thr Gln Leu Val Ala Pro Ser

500 505 510Glu Phe Ala Ala Thr Pro Val Pro Pro Pro Met Ser Ala Gly Ile Val

515 520 525Arg Gly Pro Arg Leu Val Pro Gly Ala Pro Val Gly Asp Gly Arg Phe

530 535 540Arg Leu Leu Ala Asp His Gly Gly Val Gln Gly Ala Arg Phe Trp Gln545 550 555 560Ala Arg Glu Ile Ala Thr Gly Lys Glu Val Ala Leu Ile Phe Val Asp

565 570 575Thr Ser Gly Asn Ala Pro Phe Ala Pro Leu Ser Ser Ala Ala Ala Ala

580 585 590Gly Ile Ala Tyr Glu Val Gln Arg Arg Thr Lys Lys Leu Ala Ser Leu

595 600 605Gly Ser Leu Ala Val Ala Pro Asn Ile His Ser Glu Ala Tyr Arg Asn

610 615 620Gly Cys Leu Ile Val Ala Asp Trp Val Pro Gly Ser Ser Leu Ser Ala625 630 635 640Val Ala Glu Ser Gly Ala Asp Pro Arg Ala Ala Ala Phe Ala Leu Ala

645 650 655Glu Leu Thr Glu Thr Ile Gly Glu Ala His Glu Met Gly Ile Pro Ala

660 665 670Gly Leu Asp Asn Lys Cys Arg Ile Arg Ile Asn Thr Asp Gly His Ala

675 680 685Val Leu Ala Leu Pro Ala Ile Leu Pro Asp Ala Ser Glu Leu Arg Asp

690 695 700Ala Lys Ser Leu Ala Ser Ala Ala Glu Met Leu Ile Asp Ala Thr Leu705 710 715 720Ala Pro Ser Asp Val Lys Ala Met Val Thr Glu Ala Gln Gly Leu Ala

725 730 735Thr Glu Asp Asn Pro Asp Tyr Ala Ser Leu Ala Met Ala Met Arg Thr

740 745 750Cys Gly Leu Phe Thr Glu Glu Pro Thr His Leu Val Val Lys Lys Glu

755 760 765Lys Thr Pro Lys Pro Ala Thr Arg Asp Gly Phe Gly Ala Ser Asp Tyr

770 775 780Thr Val Lys Gly Met Ala Ala Ile Ala Ala Val Val Ile Ile Leu Val785 790 795 800Ser Leu Val Ala Ala Gly Thr Ala Phe Leu Thr Ser Phe Phe Gly Ser

805 810 815Ser Thr Asn Glu Gln Ser Pro Leu Ala Ser Val Glu Ala Thr Thr Ser

820 825 830Ala Thr Pro Glu Pro Val Gly Pro Pro Val Tyr Leu Asp Leu Asp Gln

835 840 845Ala Arg Thr Trp Asp Asp Gly Ala Gly Thr Asp Val Thr Asp Val Thr

850 855 860Asp Gly Asn Thr Ser Thr Ala Trp Thr Ser Thr Gly Gly Asp Gly Leu865 870 875 880Leu Val Asp Leu Ser Thr Pro Ala Arg Leu Asp Arg Val Ile Leu Thr

885 890 895Thr Gly Thr Gly Ser Asp Ser Asn Val Thr Ser Thr Val Lys Ile Tyr

900 905 910Ala Phe Asn Asp Ala Ser Pro His Ser Leu Ser Glu Gly Ile Glu Ile

915 920 925Gly Thr Val Asp Tyr Ser Gly Arg Ser Leu Ser His Ser Ile Arg Asp

930 935 940Ser Ser Lys Leu Pro Gly Gln Val Glu Ser Val Val Ile Leu Val Asp945 950 955 960Glu Val Arg Ser Ser Gln Thr Ser Asp Thr Asn Pro Gln Met Gln Ile

965 970 975Ala Glu Val Gln Leu Val Gly Trp

980<210>595<211>915<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (892)<223>RXA01807<400>595gctcaccgag ctggacacca agctccgcgc agtgcaggaa gaacacggcg agctggaaat 60gcagtggctg gaactcggcg aggaaatcga gggctagttc atg ccg tcg gca ggc 115

Met Pro Ser Ala Gly

1 5gag gag att tta gag cag cgc gca cag ctg gag ttt gat cag cgc cgc 163Glu Glu Ile Leu Glu Gln Arg Ala Gln Leu Glu Phe Asp Gln Arg Arg

10 15 20gcc gat gtg gtg atg atc ggc agc cag gtg gtt tat ggt tcc gtg ggg 211Ala Asp Val Val Met Ile Gly Ser Gln Val Val Tyr Gly Ser Val Gly

25 30 35ctc agt gct gcc att ccg gtg atg cac aac gaa ggc ctc cgc gtg gtc 259Leu Ser Ala Ala Ile Pro Val Met His Asn Glu Gly Leu Arg Val Val

40 45 50gct gtc ccc acc gtg gtg tta agt tcc atg ccg cgt tat gca agt tct 307Ala Val Pro Thr Val Val Leu Ser Ser Met Pro Arg Tyr Ala Ser Ser

55 60 65cac cgc cag ccg atg tcg gac caa tgg ctc gcc gac gcg ctg caa gac 355His Arg Gln Pro Met Ser Asp Gln Trp Leu Ala Asp Ala Leu Gln Asp 70 75 80 85ctg gtg gat ctg ggg att atc gat gag gtt tcc acc att tcc acc ggc 403Leu Val Asp Leu Gly Ile Ile Asp Glu Val Ser Thr Ile Ser Thr Gly

90 95 100tat ttt acc tcc gct tct cag gtg cgt gtg gtc gct gcg tgg ctg cag 451Tyr Phe Thr Ser Ala Ser Gln Val Arg Val Val Ala Ala Trp Leu Gln

105 110 115aaa atc cgc gaa acc cat ccg cat gtg cgc atc gtg gtg gat ccc atc 499Lys Ile Arg Glu Thr His Pro His Val Arg Ile Val Val Asp Pro Ile

120 125 130atg ggg gac agt gac gtg gga att tat gtc gcc gac gag atc gca acc 547Met Gly Asp Ser Asp Val Gly Ile Tyr Val Ala Asp Glu Ile Ala Thr

135 140 145gcc atc tgc cag gac tta tgc cct ctg gct acc gga atc att ccc aat 595Ala Ile Cys Gln Asp Leu Cys Pro Leu Ala Thr Gly Ile Ile Pro Asn150 155 160 165gct ttc gag ctc tcc cac atg gtt ggc tcc ggc gat ccg cgc tcg ctg 643Ala Phe Glu Leu Ser His Met Val Gly Ser Gly Asp Pro Arg Ser Leu

170 175 180ctc ggc ccg ttt ggc gag tgg atc atc atc acc agc gcc act gaa act 691Leu Gly Pro Phe Gly Glu Trp Ile Ile Ile Thr Ser Ala Thr Glu Thr

185 190 195gtg ggc acc acc gtc acc cgc atc gtc acc cgt gac agc gtc cag gaa 739Val Gly Thr Thr Val Thr Arg Ile Val Thr Arg Asp Ser Val Gln Glu

200 205 210atc gcc tcc gcc acc gtc gat acc acg gcc aaa ggg gca ggc gac gtc 787Ile Ala Ser Ala Thr Val Asp Thr Thr Ala Lys Gly Ala Gly Asp Val

215 220 225tac gcc gca gca tta atc gcc gcc ctg cat aaa gat ttt tcg ctt atc 835Tyr Ala Ala Ala Leu Ile Ala Ala Leu His Lys Asp Phe Ser Leu Ile230 235 240 245gac gcc gcc agc cac gca tcc aac acc gtc tgc gcc ggc ctg cag acc 883Asp Ala Ala Ser His Ala Ser Asn Thr Val Cys Ala Gly Leu Gln Thr

250255260 aaa gcg ctt taggtttcgt ccgtctctga cag 915Lys Ala Leu<210>596<211>264<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>596Met Pro Ser Ala Gly Glu Glu Ile Leu Glu Gln Arg Ala Gln Leu Glu 151015 Phe Asp Gln Arg Arg Ala Asp Val Val Met Ile Gly Ser Gln Val Val

20 25 30Tyr Gly Ser Val Gly Leu Ser Ala Ala Ile Pro Val Met His Asn Glu

35 40 45Gly Leu Arg Val Val Ala Val Pro Thr Val Val Leu Ser Ser Met Pro

50 55 60Arg Tyr Ala Ser Ser His Arg Gln Pro Met Ser Asp Gln Trp Leu Ala 65 70 7580 Asp Ala Leu Gln Asp Leu Val Asp Leu Gly Ile Ile Asp Glu Val Ser

85 90 95Thr Ile Ser Thr Gly Tyr Phe Thr Ser Ala Ser Gln Val Arg Val Val

100 105 110Ala Ala Trp Leu Gln Lys Ile Arg Glu Thr His Pro His Val Arg Ile

115 120 125Val Val Asp Pro Ile Met Gly Asp Ser Asp Val Gly Ile Tyr Val Ala

130 135 140Asp Glu Ile Ala Thr Ala Ile Cys Gln Asp Leu Cys Pro Leu Ala Thr145 150 155 160Gly Ile Ile Pro Asn Ala Phe Glu Leu Ser His Met Val Gly Ser Gly

165 170 175Asp Pro Arg Ser Leu Leu Gly Pro Phe Gly Glu Trp Ile Ile Ile Thr

180 185 190Ser Ala Thr Glu Thr Val Gly Thr Thr Val Thr Arg Ile Val Thr Arg

195 200 205Asp Ser Val Gln Glu Ile Ala Ser Ala Thr Val Asp Thr Thr Ala Lys

210 215 220Gly Ala Gly Asp Val Tyr Ala Ala Ala Leu Ile Ala Ala Leu His Lys225 230 235 240Asp Phe Ser Leu Ile Asp Ala Ala Ser His Ala Ser Asn Thr Val Cys

245 250 255Ala Gly Leu Gln Thr Lys Ala Leu

260<210>597<211>1461<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1438)<223>RXN02754<400>597attatgaagc catcggagtt ggtgtggcct acaagggtga tcatgcgtgg atagtggtgg 60agttcactgt agctcccgct gattccgtag aatcaacaga gtg aat acc aat ccg 115

Val Asn Thr Asn Pro

1 5tct gaa ttc tcc tca aac cgt tca aca gct ctc ctt act gat aaa tat 163Ser Glu Phe Ser Ser Asn Arg Ser Thr Ala Leu Leu Thr Asp Lys Tyr

10 15 20gag ctg acc atg ctt caa gca gcg ctc gct gat ggt tct gca gaa cgc 211Glu Leu Thr Met Leu Gln Ala Ala Leu Ala Asp Gly Ser Ala Glu Arg

25 30 35ccc tca acg ttt gag gtc ttt agc cgc cgc ctc ccc aac gag cgc cga 259Pro Ser Thr Phe Glu Val Phe Ser Arg Arg Leu Pro Asn Glu Arg Arg

40 45 50tac ggt gtc gtc gca gga aca gca cga gtg ctg aag gcg att cgt gac 307Tyr Gly Val Val Ala Gly Thr Ala Arg Val Leu Lys Ala Ile Arg Asp

55 60 65ttt gta ttc aca gag gaa caa ctc gcc gat ctt gac ttt tta gac gac 355Phe Val Phe Thr Glu Glu Gln Leu Ala Asp Leu Asp Phe Leu Asp Asp 70 75 80 85cgt acc ctg gaa tac ctc cgc aac tac cga ttc acc ggc caa gtt gat 403Arg Thr Leu Glu Tyr Leu Arg Asn Tyr Arg Phe Thr Gly Gln Val Asp

90 95 100ggc tac cgc gaa ggc gaa atc tac ttc ccg cag tcc cct ctt ctg act 451Gly Tyr Arg Glu Gly Glu Ile Tyr Phe Pro Gln Ser Pro Leu Leu Thr

105 110 115gtg cgt ggc acg ttt gca gaa tgc gtc atc cta gaa act gtc att ttg 499Val Arg Gly Thr Phe Ala Glu Cys Val Ile Leu Glu Thr Val Ile Leu

120 125 130tcc atc atg aat gca gat tct gcc gtc gct tcc gcc gct gcg cgc atg 547Ser Ile Met Asn Ala Asp Ser Ala Val Ala Ser Ala Ala Ala Arg Met

135 140 145gtc acc gca gct gat ggt cgc ccc atc atc gaa atg gga tcc agg cgc 595Val Thr Ala Ala Asp Gly Arg Pro Ile Ile Glu Met Gly Ser Arg Arg150 155 160 165acc cac gaa tac tcg gca gtc acc gca tcc cgc gca gca tac ctc gct 643Thr His Glu Tyr Ser Ala Val Thr Ala Ser Arg Ala Ala Tyr Leu Ala

170 175 180gga ttc tcc acc acc tcc aac ctc gag gcg gcc tac cgc tac gga att 691Gly Phe Ser Thr Thr Ser Asn Leu Glu Ala Ala Tyr Arg Tyr Gly Ile

185 190 195cca gca tcc gga acc tcc gcc cac gca tgg act ttg ctg cac atc aac 739Pro Ala Ser Gly Thr Ser Ala His Ala Trp Thr Leu Leu His Ile Asn

200 205 210gat gac ggc acc ccc aac gaa gca gca gct ttc aaa gca cag gtt gaa 787Asp Asp Gly Thr Pro Asn Glu Ala Ala Ala Phe Lys Ala Gln Val Glu

215 220 225tcc ctc ggc gtg gac acc acc ttg ctg gta gat act tat gac atc acc 835Ser Leu Gly Val Asp Thr Thr Leu Leu Val Asp Thr Tyr Asp Ile Thr230 235 240 245caa ggt gtg gcc acc gcc att gaa gtt gca ggt cca gac ctt ggt ggc 883Gln Gly Val Ala Thr Ala Ile Glu Val Ala Gly Pro Asp Leu Gly Gly

250 255 260gta cgt atc gac tcc ggc gac cta ggt gtg ctt gcc cga aag gtc cgc 931Val Arg Ile Asp Ser Gly Asp Leu Gly Val Leu Ala Arg Lys Val Arg

265 270 275aag cag ctc gac gat ctc aac gcc cac aac acc aag att gtg gtc tcc 979Lys Gln Leu Asp Asp Leu Asn Ala His Asn Thr Lys Ile Val Val Ser

280285 290tcc gac ctg gat gaa ttc gcc atc gcg ggt ctt cgc ggc gaa cca gtt 1027Ser Asp Leu Asp Glu Phe Ala Ile Ala Gly Leu Arg Gly Glu Pro Val

295 300 305gac gtc ttt ggc gtt ggc acc tcc gtt gtc aca ggt tct ggc gca cca 1075Asp Val Phe Gly Val Gly Thr Ser Val Val Thr Gly Ser Gly Ala Pro310 315 320 325acc gct ggc ctc gtg tac aag atc ggg gaa gtt gcc ggt cac cct gtg 1123Thr Ala Gly Leu Val Tyr Lys Ile Gly Glu Val Ala Gly His Pro Val

330 335 340gcc aag cgt tcc cga aac aag gaa agc tac ggt ggt ggc aag aag gct 1171Ala Lys Arg Ser Arg Asn Lys Glu Ser Tyr Gly Gly Gly Lys Lys Ala

345 350 355gtg cgc acc cac cgc aag tcc ggt acc gca atc gaa gaa atc gtc tac 1219Val Arg Thr His Arg Lys Ser Gly Thr Ala Ile Glu Glu Ile Val Tyr

360 365 370cca ttc aat gcc gaa gca cca gat act gga aag ctc gac act ttg agc 1267Pro Phe Asn Ala Glu Ala Pro Asp Thr Gly Lys Leu Asp Thr Leu Ser

375 380 385ctg acc atc cca ttg atg cgc gac ggt gaa atc gtt cca ggt ttg cct 1315Leu Thr Ile Pro Leu Met Arg Asp Gly Glu Ile Val Pro Gly Leu Pro390 395 400 405act ttg gaa gat tcc cga gcg tat ttg gcc aag caa ttg gtc tct tta 1363Thr Leu Glu Asp Ser Arg Ala Tyr Leu Ala Lys Gln Leu Val Ser Leu

410 415 420cca tgg gaa ggc ctt gca ctg tct cgc gat gag cct gtt ttg cac act 1411Pro Trp Glu Gly Leu Ala Leu Ser Arg Asp Glu Pro Val Leu His Thr

425 430 435cgt ttc gtg ggt ttc ccg ccg gcc gct tagacaattcggtctcacca 1458Arg Phe Val Gly Phe Pro Pro Ala Ala

440445 aac 1461<210>598<211>446<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>598Val Asn Thr Asn Pro Ser Glu Phe Ser Ser Asn Arg Ser Thr Ala Leu 151015 Leu Thr Asp Lys Tyr Glu Leu Thr Met Leu Gln Ala Ala Leu Ala Asp

20 25 30Gly Ser Ala Glu Arg Pro Ser Thr Phe Glu Val Phe Ser Arg Arg Leu

35 40 45Pro Asn Glu Arg Arg Tyr Gly Val Val Ala Gly Thr Ala Arg Val Leu

50 55 60Lys Ala Ile Arg Asp Phe Val Phe Thr Glu Glu Gln Leu Ala Asp Leu 65 70 75 80Asp Phe Leu Asp Asp Arg Thr Leu Glu Tyr Leu Arg Asn Tyr Arg Phe

85 90 95Thr Gly Gln Val Asp Gly Tyr Arg Glu Gly Glu Ile Tyr Phe Pro Gln

100 105 110Ser Pro Leu Leu Thr Val Arg Gly Thr Phe Ala Glu Cys Val Ile Leu

115 120 125Glu Thr Val Ile Leu Ser Ile Met Asn Ala Asp Ser Ala Val Ala Ser

130 135 140Ala Ala Ala Arg Met Val Thr Ala Ala Asp Gly Arg Pro Ile Ile Glu145 150 155 160Met Gly Ser Arg Arg Thr His Glu Tyr Ser Ala Val Thr Ala Ser Arg

165 170 175Ala Ala Tyr Leu Ala Gly Phe Ser Thr Thr Ser Asn Leu Glu Ala Ala

180 185 190Tyr Arg Tyr Gly Ile Pro Ala Ser Gly Thr Ser Ala His Ala Trp Thr

195200 205Leu Leu His Ile Asn Asp Asp Gly Thr Pro Asn Glu Ala Ala Ala Phe

210 215 220Lys Ala Gln Val Glu Ser Leu Gly Val Asp Thr Thr Leu Leu Val Asp225 230 235 240Thr Tyr Asp Ile Thr Gln Gly Val Ala Thr Ala Ile Glu Val Ala Gly

245 250 255Pro Asp Leu Gly Gly Val Arg Ile Asp Ser Gly Asp Leu Gly Val Leu

260 265 270Ala Arg Lys Val Arg Lys Gln Leu Asp Asp Leu Asn Ala His Asn Thr

275 280 285Lys Ile Val Val Ser Ser Asp Leu Asp Glu Phe Ala Ile Ala Gly Leu

290 295 300Arg Gly Glu Pro Val Asp Val Phe Gly Val Gly Thr Ser Val Val Thr305 310 315 320Gly Ser Gly Ala Pro Thr Ala Gly Leu Val Tyr Lys Ile Gly Glu Val

325 330 335Ala Gly His Pro Val Ala Lys Arg Ser Arg Asn Lys Glu Ser Tyr Gly

340 345 350Gly Gly Lys Lys Ala Val Arg Thr His Arg Lys Ser Gly Thr Ala Ile

355 360 365Glu Glu Ile Val Tyr Pro Phe Asn Ala Glu Ala Pro Asp Thr Gly Lys

370 375 380Leu Asp Thr Leu Ser Leu Thr Ile Pro Leu Met Arg Asp Gly Glu Ile385 390 395 400Val Pro Gly Leu Pro Thr Leu Glu Asp Ser Arg Ala Tyr Leu Ala Lys

405 410 415Gln Leu Val Ser Leu Pro Trp Glu Gly Leu Ala Leu Ser Arg Asp Glu

420 425 430Pro Val Leu His Thr Arg Phe Val Gly Phe Pro Pro Ala Ala

435440445<210>599<211>871<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (871)<223>FRXA02405<400>599attatgaagc catcggagtt ggtgtggcct acaagggtga tcatgcgtgg atagtggtgg 60agttcactgt agctcccgct gattccgtag aatcaacaga gtg aat acc aat ccg 115

Val Asn Thr Asn Pro

1 5tct gaa ttc tcc tca aac cgt tca aca gct ctc ctt act gat aaa tat 163Ser Glu Phe Ser Ser Asn Arg Ser Thr Ala Leu Leu Thr Asp Lys Tyr

10 15 20gag ctg acc atg ctt caa gca gcg ctc gct gat ggt tct gca gaa cgc 211Glu Leu Thr Met Leu Gln Ala Ala Leu Ala Asp Gly Ser Ala Glu Arg

25 30 35ccc tca acg ttt gag gtc ttt agc cgc cgc ctc ccc aac gag cgc cga 259Pro Ser Thr Phe Glu Val Phe Ser Arg Arg Leu Pro Asn Glu Arg Arg

40 45 50tac ggt gtc gtc gca gga aca gca cga gtg ctg aag gcg att cgt gac 307Tyr Gly Val Val Ala Gly Thr Ala Arg Val Leu Lys Ala Ile Arg Asp

55 60 65ttt gta ttc aca gag gaa caa ctc gcc gat ctt gac ttt tta gac gac 355Phe Val Phe Thr Glu Glu Gln Leu Ala Asp Leu Asp Phe Leu Asp Asp 70 75 80 85cgt acc ctg gaa tac ctc cgc aac tac cga ttc acc ggc caa gtt gat 403Arg Thr Leu Glu Tyr Leu Arg Asn Tyr Arg Phe Thr Gly Gln Val Asp

90 95 100ggc tac cgc gaa ggc gaa atc tac ttc ccgcag tcc cct ctt ctg act 451Gly Tyr Arg Glu Gly Glu Ile Tyr Phe Pro Gln Ser Pro Leu Leu Thr

105 110 115gtg cgt ggc acg ttt gca gaa tgc gtc atc cta gaa act gtc att ttg 499Val Arg Gly Thr Phe Ala Glu Cys Val Ile Leu Glu Thr Val Ile Leu

120 125 130tcc atc atg aat gca gat tct gcc gtc gct tcc gcc gct gcg cgc atg 547Ser Ile Met Asn Ala Asp Ser Ala Val Ala Ser Ala Ala Ala Arg Met

135 140 145gtc acc gca gct gat ggt cgc ccc atc atc gaa atg gga tcc agg cgc 595Val Thr Ala Ala Asp Gly Arg Pro Ile Ile Glu Met Gly Ser Arg Arg150 155 160 165acc cac gaa tac tcg gca gtc acc gca tcc cgc gca gca tac ctc gct 643Thr His Glu Tyr Ser Ala Val Thr Ala Ser Arg Ala Ala Tyr Leu Ala

170 175 180gga ttc tcc acc acc tcc aac ctc gag gcg gcc tac cgc tac gga att 691Gly Phe Ser Thr Thr Ser Asn Leu Glu Ala Ala Tyr Arg Tyr Gly Ile

185 190 195cca gca tcc gga acc tcc gcc cac gca tgg act ttg ctg cac atc aac 739Pro Ala Ser Gly Thr Ser Ala His Ala Trp Thr Leu Leu His Ile Asn

200 205 210gat gac ggc acc ccc aac gaa gca gca gct ttc aaa gca cag gtt gaa 787Asp Asp Gly Thr Pro Asn Glu Ala Ala Ala Phe Lys Ala Gln Val Glu

215 220 225tcc ctc ggc gtg gac acc acc ttg ctg gta gat act tat gac atc acc 835Ser Leu Gly Val Asp Thr Thr Leu Leu Val Asp Thr Tyr Asp Ile Thr230 235 240 245caa ggt gtg gcc acc gcc att gaa gtt gca ggt cca 871Gln Gly Val Ala Thr Ala Ile Glu Val Ala Gly Pro

250255<210>600<211>257<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>600Val Asn Thr Asn Pro Ser Glu Phe Ser Ser Asn Arg Ser Thr Ala Leu 151015 Leu Thr Asp Lys Tyr Glu Leu Thr Met Leu Gln Ala Ala Leu Ala Asp

20 25 30Gly Ser Ala Glu Arg Pro Ser Thr Phe Glu Val Phe Ser Arg Arg Leu

35 40 45Pro Asn Glu Arg Arg Tyr Gly Val Val Ala Gly Thr Ala Arg Val Leu

50 55 60Lys Ala Ile Arg Asp Phe Val Phe Thr Glu Glu Gln Leu Ala Asp Leu 65 70 75 80Asp Phe Leu Asp Asp Arg Thr Leu Glu Tyr Leu Arg Asn Tyr Arg Phe

85 90 95Thr Gly Gln Val Asp Gly Tyr Arg Glu Gly Glu Ile Tyr Phe Pro Gln

100 105 110Ser Pro Leu Leu Thr Val Arg Gly Thr Phe Ala Glu Cys Val Ile Leu

115 120 125Glu Thr Val Ile Leu Ser Ile Met Asn Ala Asp Ser Ala Val Ala Ser

130 135 140Ala Ala Ala Arg Met Val Thr Ala Ala Asp Gly Arg Pro Ile Ile Glu145 150 155 160Met Gly Ser Arg Arg Thr His Glu Tyr Ser Ala Val Thr Ala Ser Arg

165 170 175Ala Ala Tyr Leu Ala Gly Phe Ser Thr Thr Ser Asn Leu Glu Ala Ala

180 185 190Tyr Arg Tyr Gly Ile Pro Ala Ser Gly Thr Ser Ala His Ala Trp Thr

195 200 205Leu Leu His Ile Asn Asp Asp Gly Thr Pro Asn Glu Ala Ala Ala Phe

210 215 220Lys Ala Gln Val Glu Ser Leu Gly Val Asp Thr Thr Leu Leu Val Asp225 230 235 240Thr Tyr Asp Ile Thr Gln Gly Val Ala Thr Ala Ile Glu Val Ala Gly

245250255 Pro<210>601<211>509<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) } (486)<223>FRXA02754<400>601ccc aca aac acc aag att gtg gtc tcc tcc gac ctg gat gaa ttc gcc 48Pro Thr Asn Thr Lys Ile Val Val Ser Ser Asp Leu Asp Glu Phe Ala 151015 atc gcg ggt ctt cgc ggc gaa cca gtt gac gtc ttt ggc gtt ggc acc 96Ile Ala Gly Leu Arg Gly Glu Pro Val Asp Val Phe Gly Val Gly Thr

20 25 30tcc gtt gtc aca ggt tct ggc gca cca acc gct ggc ctc gtg tac aag 144Ser Val Val Thr Gly Ser Gly Ala Pro Thr Ala Gly Leu Val Tyr Lys

35 40 45atc ggg gaa gtt gcc ggt cac cct gtg gcc aag cgt tcc cga aac aag 192Ile Gly Glu Val Ala Gly His Pro Val Ala Lys Arg Ser Arg Asn Lys

50 55 60gaa agc tac ggt ggt ggc aag aag gct gtg cgc acc cac cgc aag tcc 240Glu Ser Tyr Gly Gly Gly Lys Lys Ala Val Arg Thr His Arg Lys Ser 65 70 75 80ggt acc gca atc gaa gaa atc gtc tac cca ttc aat gcc gaa gca cca 288Gly Thr Ala Ile Glu Glu Ile Val Tyr Pro Phe Asn Ala Glu Ala Pro

85 90 95gat act gga aag ctc gac act ttg agc ctg acc atc cca ttg atg cgc 336Asp Thr Gly Lys Leu Asp Thr Leu Ser Leu Thr Ile Pro Leu Met Arg

100 105 110gac ggt gaa atc gtt cca ggt ttg cct act ttg gaa gat tcc cga gcg384Asp Gly Glu Ile Val Pro Gly Leu Pro Thr Leu Glu Asp Ser Arg Ala

115 120 125tat ttg gcc aag caa ttg gtc tct tta cca tgg gaa ggc ctt gca ctg 432Tyr Leu Ala Lys Gln Leu Val Ser Leu Pro Trp Glu Gly Leu Ala Leu

130135140 tct cgc gat gag cct gtt ttg cac act cgt ttc gtg ggt ttc ccg ccg 480Ser Arg Asp Glu Pro Val Leu His Thr Arg Phe Val Gly Phe Pro Pro 145150155160 gcc gct tagacaattc ggtctcacca aac 509Ala<210>602<211>162<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>602Pro Thr Asn Thr Lys Ile Val Val Ser Ser Asp Leu Asp Glu Phe Ala 151015 Ile Ala Gly Leu Arg Gly Glu Pro Val Asp Val Phe Gly Val Gly Thr

20 25 30Ser Val Val Thr Gly Ser Gly Ala Pro Thr Ala Gly Leu Val Tyr Lys

35 40 45Ile Gly Glu Val Ala Gly His Pro Val Ala Lys Arg Ser Arg Asn Lys

50 55 60Glu Ser Tyr Gly Gly Gly Lys Lys Ala Val Arg Thr His Arg Lys Ser 65 70 75 80Gly Thr Ala Ile Glu Glu Ile Val Tyr Pro Phe Asn Ala Glu Ala Pro

85 90 95Asp Thr Gly Lys Leu Asp Thr Leu Ser Leu Thr Ile Pro Leu Met Arg

100 105 110Asp Gly Glu Ile Val Pro Gly Leu Pro Thr Leu Glu Asp Ser Arg Ala

115 120 125Tyr Leu Ala Lys Gln Leu Val Ser Leu Pro Trp Glu Gly Leu Ala Leu

130135140 Ser Arg Asp Glu Pro Val Leu His Thr Arg Phe Val Gly Phe Pro Pro 145150155160 Ala Ala<210>603<211>960<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (937)<223>RXA02112<400>603tgaatccgtg gcggcaccgg cgcgagtcgc tttggaaagg atgctatctg ttgttccagc 60agctcctgtt actcctagct cctcgaagga tgcgtaattt atg act acc cat att 115

Met Thr Thr His Ile

1 5gac cgc atc gtt ggc gca gcg tta tcc gag gat gcg cca tgg ggc gac 163Asp Arg Ile Val Gly Ala Ala Leu Ser Glu Asp Ala Pro Trp Gly Asp

10 15 20att acc tcc gac act ttt atc cca gga tcg gcg cag ctg agc gcc aag 211Ile Thr Ser Asp Thr Phe Ile Pro Gly Ser Ala Gln Leu Ser Ala Lys

25 30 35gtt gtt gcc cgg gag cca ggt gtg ttc agc ggg cag gcg ctt tta gac 259Val Val Ala Arg Glu Pro Gly Val Phe Ser Gly Gln Ala Leu Leu Asp

40 45 50gcc tcc ttc cgg ctc gtc gat cct agg ata aac gca tcc ctt aag gtg 307Ala Ser Phe Arg Leu Val Asp Pro Arg Ile Asn Ala Ser Leu Lys Val

55 60 65gct gat ggt gac agc ttt gaa acc ggg gac atc cta gga aca att acc 355Ala Asp Gly Asp Ser Phe Glu Thr Gly Asp Ile Leu Gly Thr Ile Thr 70 75 80 85ggc agt gct aga agc atc ctc cgt tca gag cgc att gct ctc aac ttc 403Gly Ser Ala Arg Ser Ile Leu Arg Ser Glu Arg Ile Ala Leu Asn Phe

90 95 100att cag agg acg tcc ggc atc gct aca ttg aca tcg tgc tat gtt gca 451Ile Gln Arg Thr Ser Gly Ile Ala Thr Leu Thr Ser Cys Tyr Val Ala

105 110 115gag gtt aaa ggc acc aaa gcc cgc att gtt gat acc cgg aaa acc aca 499Glu Val Lys Gly Thr Lys Ala Arg Ile Val Asp Thr Arg Lys Thr Thr

120 125 130ccc ggc ctg cgc atc att gaa cgc caa gct gtc cgt gac ggt ggc gga 547Pro Gly Leu Arg Ile Ile Glu Arg Gln Ala Val Arg Asp Gly Gly Gly

135 140 145ttt aat cac cga gcc acc ttg tcc gat gct gtc atg gtg aaa gat aac 595Phe Asn His Arg Ala Thr Leu Ser Asp Ala Val Met Val Lys Asp Asn150 155 160 165cat ctc gca gcc atc gca tcc cag ggg ctc agc atc act gaa gcg ctg 643His Leu Ala Ala Ile Ala Ser Gln Gly Leu Ser Ile Thr Glu Ala Leu

170 175 180tcg aat atg aaa gct aaa ctc ccc cac acc acc cat gtg gaa gtc gaa 691Ser Asn Met Lys Ala Lys Leu Pro His Thr Thr His Val Glu Val Glu

185 190 195gtt gat cat ata gag cag atc gaa cca gtt ctt gct gct ggt gtg gac 739Val Asp His Ile Glu Gln Ile Glu Pro Val Leu Ala Ala Gly Val Asp

200 205 210acc atc atg ttg gat aat ttc acc att gat cag ctc atc gaa ggc gtt 787Thr Ile Met Leu Asp Asn Phe Thr Ile Asp Gln Leu Ile Glu Gly Val

215 220 225gat ctc att ggt gga cgt gca ctg gtg gaa gca tct ggc gga gtc aac 835Asp Leu Ile Gly Gly Arg Ala Leu Val Glu Ala Ser Gly Gly Val Asn230 235 240 245ctc aac acc gcg gga aag att gca tca acc ggt gtc gac gtc att tcc 883Leu Asn Thr Ala Gly Lys Ile Ala Ser Thr Gly Val Asp Val Ile Ser

250 255 260gtt gga gcg ctt acc cat tct gtg cat gca ctt gac cta gga ctc gat 931Val Gly Ala Leu Thr His Ser Val His Ala Leu Asp Leu Gly Leu Asp

265270275 att ttc taatgctcta ccttgataat gca 960Ile Phe<210>604<211>279<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>604Met Thr Thr His Ile Asp Arg Ile Val Gly Ala Ala Leu Ser Glu Asp 151015 Ala Pro Trp Gly Asp Ile Thr Ser Asp Thr Phe Ile Pro Gly Ser Ala

20 25 30Gln Leu Ser Ala Lys Val Val Ala Arg Glu Pro Gly Val Phe Ser Gly

35 40 45Gln Ala Leu Leu Asp Ala Ser Phe Arg Leu Val Asp Pro Arg Ile Asn

50 55 60Ala Ser Leu Lys Val Ala Asp Gly Asp Ser Phe Glu Thr Gly Asp Ile 65 70 75 80Leu Gly Thr Ile Thr Gly Ser Ala Arg Ser Ile Leu Arg Ser Glu Arg

85 90 95Ile Ala Leu Asn Phe Ile Gln Arg Thr Ser Gly Ile Ala Thr Leu Thr

100 105 110Ser Cys Tyr Val Ala Glu Val Lys Gly Thr Lys Ala Arg Ile Val Asp

115 120 125Thr Arg Lys Thr Thr Pro Gly Leu Arg Ile Ile Glu Arg Gln Ala Val

130 135 140Arg Asp Gly Gly Gly Phe Asn His Arg Ala Thr Leu Ser Asp Ala Val145 150 155 160Met Val Lys Asp Asn His Leu Ala Ala Ile Ala Ser Gln Gly Leu Ser

165 170 175Ile Thr Glu Ala Leu Ser Asn Met Lys Ala Lys Leu Pro His Thr Thr

180 185 190His Val Glu Val Glu Val Asp His Ile Glu Gln Ile Glu Pro Val Leu

195 200205Ala Ala Gly Val Asp Thr Ile Met Leu Asp Asn Phe Thr Ile Asp Gln

210 215 220Leu Ile Glu Gly Val Asp Leu Ile Gly Gly Arg Ala Leu Val Glu Ala225 230 235 240Ser Gly Gly Val Asn Leu Asn Thr Ala Gly Lys Ile Ala Ser Thr Gly

245 250 255Val Asp Val Ile Ser Val Gly Ala Leu Thr His Ser Val His Ala Leu

260 265 270Asp Leu Gly Leu Asp Ile Phe

275<210>605<211>1407<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1384)<223>RXA02111<400>605gcttgcggga acaccgcacc gcccacccaa actgttcaga ttccaaagat aaattctgac 60gctcattcca gcccaccgtt tagaagaaaa gaccccaatc atg acc acc tca atc 115

Met Thr Thr Ser Ile

1 5acc cca tct gtc aac ctt gca ttg aaa aat gcc aat agc tgc aac agt 163Thr Pro Ser Val Asn Leu Ala Leu Lys Asn Ala Asn Ser Cys Asn Ser

10 15 20gaa ctc aaa gac gga ccc tgg ttc ctc gac cag ccc gga atg ccg gat 211Glu Leu Lys Asp Gly Pro Trp Phe Leu Asp Gln Pro Gly Met Pro Asp

25 30 35gtc tac ggc ccc ggc gcg tca caa aac gat ccg atc cct gcg cat gct 259Val Tyr Gly Pro Gly Ala Ser Gln Asn Asp Pro Ile Pro Ala His Ala

40 45 50ccg cgc cag cag gtt ctc ccc gag gag tac cag cgc gca agt gat gac 307Pro Arg Gln Gln Val Leu Pro Glu Glu Tyr Gln Arg Ala Ser Asp Asp

55 60 65gaa ctg cat cgt agg atc cgg gaa gcg aaa gac acc ctg ggt gac aaa 355Glu Leu His Arg Arg Ile Arg Glu Ala Lys Asp Thr Leu Gly Asp Lys 70 75 80 85gtg gtt atc cta gga cac ttc tac cag cgc gat gaa gtt atc caa cac 403Val Val Ile Leu Gly His Phe Tyr Gln Arg Asp Glu Val Ile Gln His

90 95 100gca gat ttt gtt ggt gac tct ttc caa ctt gcc cgc gct gcc aaa acc 451Ala Asp Phe Val Gly Asp Ser Phe Gln Leu Ala Arg Ala Ala Lys Thr

105 110 115cga ccc gag gcg gaa gcg att gtg ttc tgc ggt gtg cac ttc atg gct 499Arg Pro Glu Ala Glu Ala Ile Val Phe Cys Gly Val His Phe Met Ala

120 125 130gaa acc gct gat ctg tta tcc acg gat gaa caa tca gtg atc ctc ccc 547Glu Thr Ala Asp Leu Leu Ser Thr Asp Glu Gln Ser Val Ile Leu Pro

135 140 145aac ctt gcc gca ggt tgc tcc atg gca gac atg gct gac ctt gat tcc 595Asn Leu Ala Ala Gly Cys Ser Met Ala Asp Met Ala Asp Leu Asp Ser150 155 160 165gtc gaa gac tgc tgg gag caa ctc acc tca att tat ggc gat gac acc 643Val Glu Asp Cys Trp Glu Gln Leu Thr Ser Ile Tyr Gly Asp Asp Thr

170 175 180ctg atc cct gtg acc tac atg aat tcc tct gca gcg ctc aaa ggt ttc 691Leu Ile Pro Val Thr Tyr Met Asn Ser Ser Ala Ala Leu Lys Gly Phe

185 190 195gtg ggt gag cac ggc gga att gta tgc acc tcc tca aat gca cgt tcc 739Val Gly Glu His Gly Gly Ile Val Cys Thr Ser Ser Asn Ala Arg Ser

200 205 210gta ttg gag tgg gcg ttt gaa cgc ggc caa cga gtc ctg ttc ttc ccc 787Val Leu Glu Trp Ala Phe Glu Arg Gly Gln Arg Val Leu Phe Phe Pro

215 220 225gat cag cac ttg ggt cga aac acc gcg aaa gcc atg ggc att ggg atc 835Asp Gln His Leu Gly Arg Asn Thr Ala Lys Ala Met Gly Ile Gly Ile230 235 240 245gat caa atg ccc ctg tgg aat ccc aac aaa cca ctg ggt ggc aac acc 883Asp Gln Met Pro Leu Trp Asn Pro Asn Lys Pro Leu Gly Gly Asn Thr

250 255 260gtt tcc gag cta gaa aac gca aag gta ctg ctc tgg cat ggt ttc tgc 931Val Ser Glu Leu Glu Asn Ala Lys Val Leu Leu Trp His Gly Phe Cys

265 270 275tct gta cac aag cgc ttt act gtc gag cag atc aac aaa gcc cgc gcc 979Ser Val His Lys Arg Phe Thr Val Glu Gln Ile Asn Lys Ala Arg Ala

280 285 290gag tac ccc gac gtt cac gtc atc gtg cac cct gaa tcc ccc atg cca 1027Glu Tyr Pro Asp Val His Val Ile Val His Pro Glu Ser Pro Met Pro

295 300 305gtt gtt gac gcc gcc gac tca tcc gga tcc act gac ttc att gtg aaa 1075Val Val Asp Ala Ala Asp Ser Ser Gly Ser Thr Asp Phe Ile Val Lys310 315 320 325gcc att caa gca gca ccg gca gga tct acc ttt gcg atc ggc acc gaa 1123Ala Ile Gln Ala Ala Pro Ala Gly Ser Thr Phe Ala Ile Gly Thr Glu

330 335 340atc aac ttg gtt cag cgc ctg gca gcc cag tac ccg cag cac acc atc 1171Ile Asn Leu Val Gln Arg Leu Ala Ala Gln Tyr Pro Gln His Thr Ile

345 350 355ttc tgc ctc gac cct gtc atc tgc cca tgc tcc acc atg tat cgc att 1219Phe Cys Leu Asp Pro Val Ile Cys Pro Cys Ser Thr Met Tyr Arg Ile

360 365 370cac cct ggt tac ctg gcc tgg gca ctt gag gag ttg gtg gct gga aac 1267His Pro Gly Tyr Leu Ala Trp Ala Leu Glu Glu Leu Val Ala Gly Asn

375 380 385gtg att aac cag att tct gtc tct gaa tcc gtg gcg gca ccg gcg cga 1315Val Ile Asn Gln Ile Ser Val Ser Glu Ser Val Ala Ala Pro Ala Arg390 395 400 405gtc gct ttg gaa agg atg cta tct gtt gtt cca gca gct cct gtt act 1363Val Ala Leu Glu Arg Met Leu Ser Val Val Pro Ala Ala Pro Val Thr

410 415 420cct agc tcc tcg aag gat gcg taatttatga ctacccatat tga 1407Pro Ser Ser Ser Lys Asp Ala

425<210>606<211>428<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>606Met Thr Thr Ser Ile Thr Pro Ser Val Asn Leu Ala Leu Lys Asn Ala 151015 Asn Ser Cys Asn Ser Glu Leu Lys Asp Gly Pro Trp Phe Leu Asp Gln

20 25 30Pro Gly Met Pro Asp Val Tyr Gly Pro Gly Ala Ser Gln Asn Asp Pro

35 40 45Ile Pro Ala His Ala Pro Arg Gln Gln Val Leu Pro Glu Glu Tyr Gln

50 55 60Arg Ala Ser Asp Asp Glu Leu His Arg Arg Ile Arg Glu Ala Lys Asp 65 70 75 80Thr Leu Gly Asp Lys Val Val Ile Leu Gly His Phe Tyr Gln Arg Asp

85 90 95Glu Val Ile Gln His Ala Asp Phe Val Gly Asp Ser Phe Gln Leu Ala

100 105 110Arg Ala Ala Lys Thr Arg Pro Glu Ala Glu Ala Ile Val Phe Cys Gly

115 120 125Val His Phe Met Ala Glu Thr Ala Asp Leu Leu Ser Thr Asp Glu Gln

130 135 140Ser Val Ile Leu Pro Asn Leu Ala Ala Gly Cys Ser Met Ala Asp Met145 150 155 160Ala Asp Leu Asp Ser Val Glu Asp Cys Trp Glu Gln Leu Thr Ser Ile

165 170 175Tyr Gly Asp Asp Thr Leu Ile Pro Val Thr Tyr Met Asn Ser Ser Ala

180 185 190Ala Leu Lys Gly Phe Val Gly Glu His Gly Gly Ile Val Cys Thr Ser

195 200 205Ser Asn Ala Arg Ser Val Leu Glu Trp Ala Phe Glu Arg Gly Gln Arg

210 215 220Val Leu Phe Phe Pro Asp Gln His Leu Gly Arg Asn Thr Ala Lys Ala225 230 235 240Met Gly Ile Gly Ile Asp Gln Met Pro Leu Trp Asn Pro Asn Lys Pro

245 250 255Leu Gly Gly Asn Thr Val Ser Glu Leu Glu Asn Ala Lys Val Leu Leu

260 265 270Trp His Gly Phe Cys Ser Val His Lys Arg Phe Thr Val Glu Gln Ile

275 280 285Asn Lys Ala Arg Ala Glu Tyr Pro Asp Val His Val Ile Val His Pro

290 295 300Glu Ser Pro Met Pro Val Val Asp Ala Ala Asp Ser Ser Gly Ser Thr305 310 315 320Asp Phe Ile Val Lys Ala Ile Gln Ala Ala Pro Ala Gly Ser Thr Phe

325 330 335Ala Ile Gly Thr Glu Ile Asn Leu Val Gln Arg Leu Ala Ala Gln Tyr

340 345 350Pro Gln His Thr Ile Phe Cys Leu Asp Pro Val Ile Cys Pro Cys Ser

355 360 365Thr Met Tyr Arg Ile His Pro Gly Tyr Leu Ala Trp Ala Leu Glu Glu

370 375 380Leu Val Ala Gly Asn Val Ile Asn Gln Ile Ser Val Ser Glu Ser Val385 390 395 400Ala Ala Pro Ala Arg Val Ala Leu Glu Arg Met Leu Ser Val Val Pro

405 410 415Ala Ala Pro Val Thr Pro Ser Ser Ser Lys Asp Ala

420425<210>607<211>954<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (931)<223>RXA01073<400>607taaccgactc cagcactaaa ctccaaaccc ttggcccgca ccgccaaagt ttagcgcgcc 60ccaagacacc accgcgccat gtttgcctag gattaggtac atg aca aac act caa 115

Met Thr Asn Thr Gln

1 5acc gag atc att aat gaa cta aag gtg agc cca gca atc gac gtg gcc 163Thr Glu Ile Ile Asn Glu Leu Lys Val Ser Pro Ala Ile Asp Val Ala

10 15 20aag gaa gtt gaa ttc cgt gtg cag ttc ctc gtc gat tac ctg cgg gct 211Lys Glu Val Glu Phe Arg Val Gln Phe Leu Val Asp Tyr Leu Arg Ala

25 30 35tcc cat aca aaa ggc ttt gtt ctt ggt att tca ggt ggc cag gat tcc 259Ser His Thr Lys Gly Phe Val Leu Gly Ile Ser Gly Gly Gln Asp Ser

40 45 50act ctt gcg gga cga ctc acg cag ctg gca gta gag cgc att cgt gcg 307Thr Leu Ala Gly Arg Leu Thr Gln Leu Ala Val Glu Arg Ile Arg Ala

55 60 65gaa gaa aac agc acg gat tat gtc ttc tac gca gtt cgc ctc ccc tac 355Glu Glu Asn Ser Thr Asp Tyr Val Phe Tyr Ala Val Arg Leu Pro Tyr 70 75 80 85gcg atc cag gca gat gag gac gat gcg caa gtt gca ttg gaa ttc atc 403Ala Ile Gln Ala Asp Glu Asp Asp Ala Gln Val Ala Leu Glu Phe Ile

90 95 100gca cct gac aag agc gtg acc gtc aac gtt aaa gac gca acg gac gcc 451Ala Pro Asp Lys Ser Val Thr Val Asn Val Lys Asp Ala Thr Asp Ala

105 110 115acc gaa gca act gtt gca gct gct ttg gaa ctt cct gag ctg acc gac 499Thr Glu Ala Thr Val Ala Ala Ala Leu Glu Leu Pro Glu Leu Thr Asp

120 125 130ttc aat cgg ggc aat att aaa gct cgc caa cgc atg gtt gcc cag tac 547Phe Asn Arg Gly Asn Ile Lys Ala Arg Gln Arg Met Val Ala Gln Tyr

135 140 145gca atc gca ggc cag ttg ggc ttg ctg gtt att ggc act gat cac gcg 595Ala Ile Ala Gly Gln Leu Gly Leu Leu Val Ile Gly Thr Asp His Ala150 155 160 165gct gaa aac gtc acg ggg ttc ttc acc aaa ttc ggt gat ggc gca gct 643Ala Glu Asn Val Thr Gly Phe Phe Thr Lys Phe Gly Asp Gly Ala Ala

170 175 180gac ctg ctt cct ttg gca ggt ttg agc aag cgt caa gga gct gcc att 691Asp Leu Leu Pro Leu Ala Gly Leu Ser Lys Arg Gln Gly Ala Ala Ile

185 190 195ctg gag cac ctg ggt gca cct tca agc acg tgg acc aag gtt cct acc 739Leu Glu His Leu Gly Ala Pro Ser Ser Thr Trp Thr Lys Val Pro Thr

200205 210gct gat ttg gaa gag gat cgc cca gcg ttg cca gat gag gaa gca ctt 787Ala Asp Leu Glu Glu Asp Arg Pro Ala Leu Pro Asp Glu Glu Ala Leu

215 220 225ggt gtg tcg tat gcg gac atc gat aat tac ctg gaa aac aag ccc gat 835Gly Val Ser Tyr Ala Asp Ile Asp Asn Tyr Leu Glu Asn Lys Pro Asp230 235 240 245gtc agt gaa aaa gcc cag cag cgc att gag cac ctg tgg aag gtg ggc 883Val Ser Glu Lys Ala Gln Gln Arg Ile Glu His Leu Trp Lys Val Gly

250 255 260cag cac aag cgc cac ctc cct gct acc ccg cag gaa aat tgg tgg cgt 931Gln His Lys Arg His Leu Pro Ala Thr Pro Gln Glu Asn Trp Trp Arg

265270275 taatccaaca gtttgagtgt cgc 954<210>608<211>277<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>608Met Thr Asn Thr Gln Thr Glu Ile Ile Asn Glu Leu Lys Val Ser Pro 151015 Ala Ile Asp Val Ala Lys Glu Val Glu Phe Arg Val Gln Phe Leu Val

20 25 30Asp Tyr Leu Arg Ala Ser His Thr Lys Gly Phe Val Leu Gly Ile Ser

35 40 45Gly Gly Gln Asp Ser Thr Leu Ala Gly Arg Leu Thr Gln Leu Ala Val

50 55 60Glu Arg Ile Arg Ala Glu Glu Asn Ser Thr Asp Tyr Val Phe Tyr Ala5 70 75 80Val Arg Leu Pro Tyr Ala Ile Gln Ala Asp Glu Asp Asp Ala Gln Val

85 90 95Ala Leu Glu Phe Ile Ala Pro Asp Lys Ser Val Thr Val Asn Val Lys

100 105 110Asp Ala Thr Asp Ala Thr Glu Ala Thr Val Ala Ala Ala Leu Glu Leu

115 120 125Pro Glu Leu Thr Asp Phe Asn Arg Gly Asn Ile Lys Ala Arg Gln Arg

130 135 140Met Val Ala Gln Tyr Ala Ile Ala Gly Gln Leu Gly Leu Leu Val Ile145 150 155 160Gly Thr Asp His Ala Ala Glu Asn Val Thr Gly Phe Phe Thr Lys Phe

165 170 175Gly Asp Gly Ala Ala Asp Leu Leu Pro Leu Ala Gly Leu Ser Lys Arg

180 185 190Gln Gly Ala Ala Ile Leu Glu His Leu Gly Ala Pro Ser Ser Thr Trp

195 200 205Thr Lys Val Pro Thr Ala Asp Leu Glu Glu Asp Arg Pro Ala Leu Pro

210 215 220Asp Glu Glu Ala Leu Gly Val Ser Tyr Ala Asp Ile Asp Asn Tyr Leu225 230 235 240Glu Asn Lys Pro Asp Val Ser Glu Lys Ala Gln Gln Arg Ile Glu His

245 250 255Leu Trp Lys Val Gly Gln His Lys Arg His Leu Pro Ala Thr Pro Gln

260 265 270Glu Asn Trp Trp Arg

275<210>609<211>1461<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1438)<223>RXN02754<400>609attatgaagc catcggagtt ggtgtggcct acaagggtga tcatgcgtgg atagtggtgg 60agttcactgt agctcccgct gattccgtag aatcaacaga gtg aat acc aat ccg 115

Val Asn Thr Asn Pro

1 5tct gaa ttc tcc tca aac cgt tca aca gct ctc cttact gat aaa tat 163Ser Glu Phe Ser Ser Asn Arg Ser Thr Ala Leu Leu Thr Asp Lys Tyr

10 15 20gag ctg acc atg ctt caa gca gcg ctc gct gat ggt tct gca gaa cgc 211Glu Leu Thr Met Leu Gln Ala Ala Leu Ala Asp Gly Ser Ala Glu Arg

25 30 35ccc tca acg ttt gag gtc ttt agc cgc cgc ctc ccc aac gag cgc cga 259Pro Ser Thr Phe Glu Val Phe Ser Arg Arg Leu Pro Asn Glu Arg Arg

40 45 50tac ggt gtc gtc gca gga aca gca cga gtg ctg aag gcg att cgt gac 307Tyr Gly Val Val Ala Gly Thr Ala Arg Val Leu Lys Ala Ile Arg Asp

55 60 65ttt gta ttc aca gag gaa caa ctc gcc gat ctt gac ttt tta gac gac 355Phe Val Phe Thr Glu Glu Gln Leu Ala Asp Leu Asp Phe Leu Asp Asp 70 75 80 85cgt acc ctg gaa tac ctc cgc aac tac cga ttc acc ggc caa gtt gat 403Arg Thr Leu Glu Tyr Leu Arg Asn Tyr Arg Phe Thr Gly Gln Val Asp

90 95 100ggc tac cgc gaa ggc gaa atc tac ttc ccg cag tcc cct ctt ctg act 451Gly Tyr Arg Glu Gly Glu Ile Tyr Phe Pro Gln Ser Pro Leu Leu Thr

105 110 115gtg cgt ggc acg ttt gca gaa tgc gtc atc cta gaa act gtc att ttg 499Val Arg Gly Thr Phe Ala Glu Cys Val Ile Leu Glu Thr Val Ile Leu

120 125 130tcc atc atg aat gca gat tct gcc gtc gct tcc gcc gct gcg cgc atg 547Ser Ile Met Asn Ala Asp Ser Ala Val Ala Ser Ala Ala Ala Arg Met

135 140 145gtc acc gca gct gat ggt cgc ccc atc atc gaa atg gga tcc agg cgc 595Val Thr Ala Ala Asp Gly Arg Pro Ile Ile Glu Met Gly Ser Arg Arg150 155 160 165acc cac gaa tac tcg gca gtc acc gca tcc cgc gca gca tac ctc gct 643Thr His Glu Tyr Ser Ala Val Thr Ala Ser Arg Ala Ala Tyr Leu Ala

170 175 180gga ttc tcc acc acc tcc aac ctc gag gcg gcc tac cgc tac gga att 691Gly Phe Ser Thr Thr Ser Asn Leu Glu Ala Ala Tyr Arg Tyr Gly Ile

185 190 195cca gca tcc gga acc tcc gcc cac gca tgg act ttg ctg cac atc aac 739Pro Ala Ser Gly Thr Ser Ala His Ala Trp Thr Leu Leu His Ile Asn

200 205 210gat gac ggc acc ccc aac gaa gca gca gct ttc aaa gca cag gtt gaa 787Asp Asp Gly Thr Pro Asn Glu Ala Ala Ala Phe Lys Ala Gln Val Glu

215 220 225tcc ctc ggc gtg gac acc acc ttg ctg gta gat act tat gac atc acc 835Ser Leu Gly Val Asp Thr Thr Leu Leu Val Asp Thr Tyr Asp Ile Thr230 235 240 245caa ggt gtg gcc acc gcc att gaa gtt gca ggt cca gac ctt ggt ggc 883Gln Gly Val Ala Thr Ala Ile Glu Val Ala Gly Pro Asp Leu Gly Gly

250 255 260gta cgt atc gac tcc ggc gac cta ggt gtg ctt gcc cga aag gtc cgc 931Val Arg Ile Asp Ser Gly Asp Leu Gly Val Leu Ala Arg Lys Val Arg

265 270 275aag cag ctc gac gat ctc aac gcc cac aac acc aag att gtg gtc tcc 979Lys Gln Leu Asp Asp Leu Asn Ala His Asn Thr Lys Ile Val Val Ser

280 285 290tcc gac ctg gat gaa ttc gcc atc gcg ggt ctt cgc ggc gaa cca gtt 1027Ser Asp Leu Asp Glu Phe Ala Ile Ala Gly Leu Arg Gly Glu Pro Val

295 300 305gac gtc ttt ggc gtt ggc acctcc gtt gtc aca ggt tct ggc gca cca 1075Asp Val Phe Gly Val Gly Thr Ser Val Val Thr Gly Ser Gly Ala Pro310 315 320 325acc gct ggc ctc gtg tac aag atc ggg gaa gtt gcc ggt cac cct gtg 1123Thr Ala Gly Leu Val Tyr Lys Ile Gly Glu Val Ala Gly His Pro Val

330 335 340gcc aag cgt tcc cga aac aag gaa agc tac ggt ggt ggc aag aag gct 1171Ala Lys Arg Ser Arg Asn Lys Glu Ser Tyr Gly Gly Gly Lys Lys Ala

345 350 355gtg cgc acc cac cgc aag tcc ggt acc gca atc gaa gaa atc gtc tac 1219Val Arg Thr His Arg Lys Ser Gly Thr Ala Ile Glu Glu Ile Val Tyr

360 365 370cca ttc aat gcc gaa gca cca gat act gga aag ctc gac act ttg agc 1267Pro Phe Asn Ala Glu Ala Pro Asp Thr Gly Lys Leu Asp Thr Leu Ser

375 380 385ctg acc arc cca ttg atg cgc gac ggt gaa atc gtt cca ggt ttg cct 1315Leu Thr Ile Pro Leu Met Arg Asp Gly Glu Ile Val Pro Gly Leu Pro390 395 400 405act ttg gaa gat tcc cga gcg tat ttg gcc aag caa ttg gtc tct tta 1363Thr Leu Glu Asp Ser Arg Ala Tyr Leu Ala Lys Gln Leu Val Ser Leu

410 415 420cca tgg gaa ggc ctt gca ctg tct cgc gat gag cct gtt ttg cac act 1411Pro Trp Glu Gly Leu Ala Leu Ser Arg Asp Glu Pro Val Leu His Thr

425 430 435cgt ttc gtg ggt ttc ccg ccg gcc gct tagacaattc ggtctcacca 1458Arg Phe Val Gly Phe Pro Pro Ala Ala

440445 aac 1461<210>610<211>446<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>610Val Asn Thr Asn ProSer Glu Phe Ser Ser Asn Arg Ser Thr Ala Leu 151015 Leu Thr Asp Lys Tyr Glu Leu Thr Met Leu Gln Ala Ala Leu Ala Asp

20 25 30Gly Ser Ala Glu Arg Pro Ser Thr Phe Glu Val Phe Ser Arg Arg Leu

35 40 45Pro Asn Glu Arg Arg Tyr Gly Val Val Ala Gly Thr Ala Arg Val Leu

50 55 60Lys Ala Ile Arg Asp Phe Val Phe Thr Glu Glu Gln Leu Ala Asp Leu 65 70 75 80Asp Phe Leu Asp Asp Arg Thr Leu Glu Tyr Leu Arg Asn Tyr Arg Phe

85 90 95Thr Gly Gln Val Asp Gly Tyr Arg Glu Gly Glu Ile Tyr Phe Pro Gln

100 105 110Ser Pro Leu Leu Thr Val Arg Gly Thr Phe Ala Glu Cys Val Ile Leu

115 120 125Glu Thr Val Ile Leu Ser Ile Met Asn Ala Asp Ser Ala Val Ala Ser

130 135 140Ala Ala Ala Arg Met Val Thr Ala Ala Asp Gly Arg Pro Ile Ile Glu145 150 155 160Met Gly Ser Arg Arg Thr His Glu Tyr Ser Ala Val Thr Ala Ser Arg

165 170 175Ala Ala Tyr Leu Ala Gly Phe Ser Thr Thr Ser Asn Leu Glu Ala Ala

180 185 190Tyr Arg Tyr Gly Ile Pro Ala Ser Gly Thr Ser Ala His Ala Trp Thr

195 200 205Leu Leu His Ile Asn Asp Asp Gly Thr Pro Asn Glu Ala Ala Ala Phe

210 215 220Lys Ala Gln Val Glu Ser Leu Gly Val Asp Thr Thr Leu Leu Val Asp225 230235 240Thr Tyr Asp Ile Thr Gln Gly Val Ala Thr Ala Ile Glu Val Ala Gly

245 250 255Pro Asp Leu Gly Gly Val Arg Ile Asp Ser Gly Asp Leu Gly Val Leu

260 265 270Ala Arg Lys Val Arg Lys Gln Leu Asp Asp Leu Asn Ala His Asn Thr

275 280 285Lys Ile Val Val Ser Ser Asp Leu Asp Glu Phe Ala Ile Ala Gly Leu

290 295 300Arg Gly Glu Pro Val Asp Val Phe Gly Val Gly Thr Ser Val Val Thr305 310 315 320Gly Ser Gly Ala Pro Thr Ala Gly Leu Val Tyr Lys Ile Gly Glu Val

325 330 335Ala Gly His Pro Val Ala Lys Arg Ser Arg Asn Lys Glu Ser Tyr Gly

340 345 350Gly Gly Lys Lys Ala Val Arg Thr His Arg Lys Ser Gly Thr Ala Ile

355 360 365Glu Glu Ile Val Tyr Pro Phe Asn Ala Glu Ala Pro Asp Thr Gly Lys

370 375 380Leu Asp Thr Leu Ser Leu Thr Ile Pro Leu Met Arg Asp Gly Glu Ile385 390 395 400Val Pro Gly Leu Pro Thr Leu Glu Asp Ser Arg Ala Tyr Leu Ala Lys

405 410 415Gln Leu Val Ser Leu Pro Trp Glu Gly Leu Ala Leu Ser Arg Asp Glu

420 425 430Pro Val Leu His Thr Arg Phe Val Gly Phe Pro Pro Ala Ala

435440445<210>611<211>531<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (508)<223>RXA02299<400>611acgcgggggt tgttgccgga tcgaaatatt cctttccttg tcatctcacg ctatgatttc 60taaaacttgc aggacaaccc ccataaggac accacaggac atg ctg cgc acc atc 115

Met Leu Arg Thr Ile

1 5ctc gga agt aag att cac cga gcc act gtc act caa gct gat cta gat 163Leu Gly Ser Lys Ile His Arg Ala Thr Val Thr Gln Ala Asp Leu Asp

10 15 20tat gtt ggc tct gta acc atc gac gcc gac ctg gtt cac gcc gcc gga 211Tyr Val Gly Ser Val Thr Ile Asp Ala Asp Leu Val His Ala Ala Gly

25 30 35ttg atc gaa ggc gaa aaa gtt gcc atc gta gac atc acc aac ggc gct 259Leu Ile Glu Gly Glu Lys Val Ala Ile Val Asp Ile Thr Asn Gly Ala

40 45 50cgt ctg gaa act tat gtc att gtg ggc gac gcc gga acg ggc aat att 307Arg Leu Glu Thr Tyr Val Ile Val Gly Asp Ala Gly Thr Gly Asn Ile

55 60 65tgc atc aat ggt gcc gct gca cac ctt att aat cct ggc gat ctt gtg 355Cys Ile Asn Gly Ala Ala Ala His Leu Ile Asn Pro Gly Asp Leu Val 70 75 80 85atc atc atg agc tac ctt cag gca act gat gcg gaa gcc aag gcg tat 403Ile Ile Met Ser Tyr Leu Gln Ala Thr Asp Ala Glu Ala Lys Ala Tyr

90 95 100gag cca aag att gtg cac gtg gac gcc gac aac cgc atc gtt gcg ctc 451Glu Pro Lys Ile Val His Val Asp Ala Asp Asn Arg Ile Val Ala Leu

105 110 115ggc aac gat ctt gcg gaa gca cta cct gga tcc ggg ctt ttg acg tcg 499Gly Asn Asp Leu Ala Glu Ala Leu Pro GlySer Gly Leu Leu Thr Ser

120 25 130aga agc att tagcgtttta gctcgccaat att 531Arg Ser Ile

135<210>612<211>136<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>612Met Leu Arg Thr Ile Leu Gly Ser Lys Ile His Arg Ala Thr Val Thr 151015 Gln Ala Asp Leu Asp Tyr Val Gly Ser Val Thr Ile Asp Ala Asp Leu

20 25 30Val His Ala Ala Gly Leu Ile Glu Gly Glu Lys Val Ala Ile Val Asp

35 40 45Ile Thr Asn Gly Ala Arg Leu Glu Thr Tyr Val Ile Val Gly Asp Ala

50 55 60Gly Thr Gly Asn Ile Cys Ile Asn Gly Ala Ala Ala His Leu Ile Asn 65 70 75 80Pro Gly Asp Leu Val Ile Ile Met Ser Tyr Leu Gln Ala Thr Asp Ala

85 90 95Glu Ala Lys Ala Tyr Glu Pro Lys Ile Val His Val Asp Ala Asp Asn

100 105 110Arg Ile Val Ala Leu Gly Asn Asp Leu Ala Glu Ala Leu Pro Gly Ser

115 120 125Gly Leu Leu Thr Ser Arg Ser Ile

130135<210>613<211>960<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (937)<223>RXA01928<400>613gcgagtacgc caccttgggc gattccttgc acgacgccgc gcaggcctac atcgccgata 60tccacgcggg taccttccca ggcgaagcgg agtcctttta atg cag gta gca acc 115

Met Gln Val Ala Thr

1 5aca aag cag gcg crt atc gac gcc ctc ctc cac cac aaa tcc gtc ggg 163Thr Lys Gln Ala Leu Ile Asp Ala Leu Leu His His Lys Ser Val Gly

10 15 20ctc gtc ccc acc atg ggt gcg cta cac agc gga cac gcc tcg ttg gtt 211Leu Val Pro Thr Met Gly Ala Leu His Ser Gly His Ala Ser Leu Val

25 30 35aaa gca gca cgc gct gaa aac gac act gtt gta gcc agt att ttt gtc 259Lys Ala Ala Arg Ala Glu Asn Asp Thr Val Val Ala Ser Ile Phe Val

40 45 50aat ccc ctg cag ttt gaa gca ctc ggt gat tgc gat gat tac cgc aac 307Asn Pro Leu Gln Phe Glu Ala Leu Gly Asp Cys Asp Asp Tyr Arg Asn

55 60 65tat ccc cgc caa ctc gac gcc gat tta gca ctg ctt gaa gag gca ggt 355Tyr Pro Arg Gln Leu Asp Ala Asp Leu Ala Leu Leu Glu Glu Ala Gly 70 75 80 85gtg gat att gtg ttc gca ccc gat gtg gag gaa atg tac ccc ggt ggc 403Val Asp Ile Val Phe Ala Pro Asp Val Glu Glu Met Tyr Pro Gly Gly

90 95 100ttg cca cta gtg tgg gcg cgc acc ggt tcc atc gga aca aaa ttg gag 451Leu Pro Leu Val Trp Ala Arg Thr Gly Ser Ile Gly Thr Lys Leu Glu

105 110 115ggt gcc agc agg cct ggc cat ttc gat ggt gtg gct acc gtg gtg gcg 499Gly Ala Ser Arg Pro Gly His Phe Asp Gly Val Ala Thr Val Val Ala

120 125 130aag ctg ttc aat ttg gtg cgc cct gat cgt gca tat ttt gga caa aaa 547Lys Leu Phe Asn Leu Val Arg Pro Asp Arg Ala Tyr Phe Gly Gln Lys

135 140145gat gct cag cag gtt gcg gtg att cgg cga ttg gtt gcc gat cta gac 595Asp Ala Gln Gln Val Ala Val Ile Arg Arg Leu Val Ala Asp Leu Asp150 155 160 165att ccc gtg gag att cgt ccc gtt ccg att att cgt ggc gcc gat ggc 643Ile Pro Val Glu Ile Arg Pro Val Pro Ile Ile Arg Gly Ala Asp Gly

170 175 180tta gcc gaa tcc agc cgc aat caa cgt ctt tct gcg gat cag cga gcg 691Leu Ala Glu Ser Ser Arg Asn Gln Arg Leu Ser Ala Asp Gln Arg Ala

185 190 195caa gct ctg gtg ctg ccg cag gtg ttg agt ggg ttg cag cgt cga aaa 739Gln Ala Leu Val Leu Pro Gln Val Leu Ser Gly Leu Gln Arg Arg Lys

200 205 210gca gct ggt gaa gcg cta gat atc caa ggt gcg cgc gac acc ttg gcc 787Ala Ala Gly Glu Ala Leu Asp Ile Gln Gly Ala Arg Asp Thr Leu Ala

215 220 225agc gcc gac ggc gtg cgc ttg gat cac ctg gaa att gtc gat cca gcc 835Ser Ala Asp Gly Val Arg Leu Asp His Leu Glu Ile Val Asp Pro Ala230 235 240 245acc ctc gaa cca tta gaa atc gac ggc ctg ctc acc caa cca gcg ttg 883Thr Leu Glu Pro Leu Glu Ile Asp Gly Leu Leu Thr Gln Pro Ala Leu

250 255 260gtg gtc ggc gcg att ttc gtg ggg ccg gtg cgg ttg atc gac aat atc 931Val Val Gly Ala Ile Phe Val Gly Pro Val Arg Leu Ile Asp Asn Ile

265270275 gag ctc tagtaccaac cctgcgttgc agc 960Glu Leu<210>614<211>279<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>614Met Gln Val Ala Thr Thr Lys Gln Ala Leu Ile Asp Ala Leu Leu His 151015 His Lys Ser Val Gly Leu Val Pro Thr Met Gly Ala Leu His Ser Gly

20 25 30His Ala Ser Leu Val Lys Ala Ala Arg Ala Glu Asn Asp Thr Val Val

35 40 45Ala Ser Ile Phe Val Asn Pro Leu Gln Phe Glu Ala Leu Gly Asp Cys

50 55 60Asp Asp Tyr Arg Asn Tyr Pro Arg Gln Leu Asp Ala Asp Leu Ala Leu 65 70 75 80Leu Glu Glu Ala Gly Val Asp Ile Val Phe Ala Pro Asp Val Glu Glu

85 90 95Met Tyr Pro Gly Gly Leu Pro Leu Val Trp Ala Arg Thr Gly Ser Ile

100 105 110Gly Thr Lys Leu Glu Gly Ala Ser Arg Pro Gly His Phe Asp Gly Val

115 120 125Ala Thr Val Val Ala Lys Leu Phe Asn Leu Val Arg Pro Asp Arg Ala

130 135 140Tyr Phe Gly Gln Lys Asp Ala Gln Gln Val Ala Val Ile Arg Arg Leu145 150 155 160Val Ala Asp Leu Asp Ile Pro Val Glu Ile Arg Pro Val Pro Ile Ile

165 170 175Arg Gly Ala Asp Gly Leu Ala Glu Ser Ser Arg Asn Gln Arg Leu Ser

180 185 190Ala Asp Gln Arg Ala Gln Ala Leu Val Leu Pro Gln Val Leu Ser Gly

195 200 205Leu Gln Arg Arg Lys Ala Ala Gly Glu Ala Leu Asp Ile Gln Gly Ala

210 215 220Arg Asp Thr Leu Ala Ser Ala Asp Gly Val Arg Leu Asp His Leu Glu225 230 235 240Ile Val Asp Pro Ala Thr Leu Glu Pro Leu Glu Ile Asp Gly Leu Leu

245 250 255Thr Gln Pro Ala Leu Val Val Gly Ala Ile Phe Val Gly Pro Val Arg

260 265 270Leu Ile Asp Asn Ile Glu Leu

275<210>615<211>936<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (913)<223>RXN01929<400>615aaaatttgac tccataacga gaacttaatc gagcaacacc cctgaacagt gaatcaaatc 60ggaatttatt tattctgagc tggtcatcac atctatactc atg ccc atg tca ggc 115

Met Pro Met Ser Gly

1 5att gat gca aag aaa atc cgc acc cgt cat ttc cgc gaa gct aaa gta 163Ile Asp Ala Lys Lys Ile Arg Thr Arg His Phe Arg Glu Ala Lys Val

10 15 20aac ggc cag aaa gtt tcg gtt ctc acc agc tat gat gcg ctt tcg gcg 211Asn Gly Gln Lys Val Ser Val Leu Thr Ser Tyr Asp Ala Leu Ser Ala

25 30 35cgc att ttt gat gag gct ggc gtc gat atg ctc ctt gtt ggt gat tcc 259Arg Ile Phe Asp Glu Ala Gly Val Asp Met Leu Leu Val Gly Asp Ser

40 45 50gct gcc aac gtt gtg ctg ggt cgc gat acc acc ttg tcg atc acc ttg 307Ala Ala Asn Val Val Leu Gly Arg Asp Thr Thr Leu Ser Ile Thr Leu

55 60 65gat gag atg att gtg ctg gcc aag gcg gtg acg atc gct acg aag cgt 355Asp Glu Met Ile Val Leu Ala Lys Ala Val Thr Ile Ala Thr Lys Arg 70 75 80 85gcg ctt gtg gtg gtt gat ctg ccg ttt ggt acc tat gag gtg agc cca 403Ala Leu Val Val Val Asp Leu Pro Phe Gly Thr Tyr Glu Val Ser Pro

90 95 100aat cag gcg gtg gag tcc gcg atc cgg gtc atg cgt gaa acg ggt gcg 451Asn Gln Ala Val Glu Ser Ala Ile Arg Val Met Arg Glu Thr Gly Ala

105 110 115gct gcg gtg aag atc gag ggt ggc gtg gag atc gcg cag acg att cga 499Ala Ala Val Lys Ile Glu Gly Gly Val Glu Ile Ala Gln Thr Ile Arg

120 125 130cgc att gtt gat gct gga att ccg gtt gtc ggc cac atc ggg tac acc 547Arg Ile Val Asp Ala Gly Ile Pro Val Val Gly His Ile Gly Tyr Thr

135 140 145ccg cag tcc gag cat tcc ttg ggc ggc cac gtg gtt cag ggt cgt ggc 595Pro Gln Ser Glu His Ser Leu Gly Gly His Val Val Gln Gly Arg Gly150 155 160 165gcg agt tct gga aag ctc atc gcc gat gcc cgc gcg ttg gag cag gcg 643Ala Ser Ser Gly Lys Leu Ile Ala Asp Ala Arg Ala Leu Glu Gln Ala

170 175 180ggt gcg ttt gcg gtt gtg ttg gag atg gtt cca gca gag gca gcg cgc 691Gly Ala Phe Ala Val Val Leu Glu Met Val Pro Ala Glu Ala Ala Arg

185 190 195gag gtt acc gag gat ctt tcc atc acc act atc gga atc ggt gcc ggc 739Glu Val Thr Glu Asp Leu Ser Ile Thr Thr Ile Gly Ile Gly Ala Gly

200 205 210aat ggc aca gat ggg cag gtt ttg gtg tgg cag gat gcc ttc ggc ctc 787Asn Gly Thr Asp Gly Gln Val Leu Val Trp Gln Asp Ala Phe Gly Leu

215 220 225aac cgc ggc aag aag cca cgc ttc gtc cgc gag tac gcc acc ttg ggc 835Asn Arg Gly Lys Lys Pro Arg Phe Val Arg Glu Tyr Ala Thr Leu Gly230 235 240 245gat tcc ttg cac gac gcc gcg caggcc tac atc gcc gat atc cac gcg 883Asp Ser Leu His Asp Ala Ala Gln Ala Tyr Ile Ala Asp Ile His Ala

250 255 260ggt acc ttc cca ggc gaa gcg gag tcc ttt taatgcaggt agcaaccaca 933Gly Thr Phe Pro Gly Glu Ala Glu Ser Phe

265270 aag 936<210>616<211>271<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>616Met Pro Met Ser Gly Ile Asp Ala Lys Lys Ile Arg Thr Arg His Phe 151015 Arg Glu Ala Lys Val Asn Gly Gln Lys Val Ser Val Leu Thr Ser Tyr

20 25 30Asp Ala Leu Ser Ala Arg Ile Phe Asp Glu Ala Gly Val Asp Met Leu

35 40 45Leu Val Gly Asp Ser Ala Ala Asn Val Val Leu Gly Arg Asp Thr Thr

50 55 60Leu Ser Ile Thr Leu Asp Glu Met Ile Val Leu Ala Lys Ala Val Thr 65 70 75 80Ile Ala Thr Lys Arg Ala Leu Val Val Val Asp Leu Pro Phe Gly Thr

85 90 95Tyr Glu Val Ser Pro Asn Gln Ala Val Glu Ser Ala Ile Arg Val Met

100 105 110Arg Glu Thr Gly Ala Ala Ala Val Lys Ile Glu Gly Gly Val Glu Ile

115 120 125Ala Gln Thr Ile Arg Arg Ile Val Asp Ala Gly Ile Pro Val Val Gly

130 135 140His Ile Gly Tyr Thr Pro Gln Ser Glu His Ser Leu Gly Gly His Val145 150 155 160Val Gln Gly Arg Gly Ala Ser Ser Gly Lys Leu Ile Ala Asp Ala Arg

165 170 175Ala Leu GluGln Ala Gly Ala Phe Ala Val Val Leu Glu Met Val Pro

180 185 190Ala Glu Ala Ala Arg Glu Val Thr Glu Asp Leu Ser Ile Thr Thr Ile

195 200 205Gly Ile Gly Ala Gly Asn Gly Thr Asp Gly Gln Val Leu Val Trp Gln

210 215 220Asp Ala Phe Gly Leu Asn Arg Gly Lys Lys Pro Arg Phe Val Arg Glu225 230 235 240Tyr Ala Thr Leu Gly Asp Ser Leu His Asp Ala Ala Gln Ala Tyr Ile

245 250 255Ala Asp Ile His Ala Gly Thr Phe Pro Gly Glu Ala Glu Ser Phe

260265270<210>617<211>930<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (907)<223>FRXA01929<400>617tgactccata acgagaactt aatcgagcaa cacccctgaa cagtgaatca aatcggaatt 60tatttattct gagctggtca tcacatctat actcatgccc atg tca ggc att gat 115

Met Ser Gly Ile Asp

1 5gca aag aaa atc cgc acc cgt cat ttc cgc gaa gct aaa gta aac ggc 163Ala Lys Lys Ile Arg Thr Arg His Phe Arg Glu Ala Lys Val Asn Gly

10 15 20cag aaa gtt tcg gtt ctc acc agc tat gat gcg ctt tcg gcg cgc att 211Gln Lys Val Ser Val Leu Thr Ser Tyr Asp Ala Leu Ser Ala Arg Ile

25 30 35ttt gat gag gct ggc gtc gat atg ctc ctt gtt ggt gat tcc gct gcc 259Phe Asp Glu Ala Gly Val Asp Met Leu Leu Val Gly Asp Ser Ala Ala

40 45 50aac gtt gtg ctg ggt cgc gat acc acc ttg tcg atc acc ttg gat gag 307Asn Val Val Leu Gly Arg Asp Thr Thr Leu Ser Ile Thr Leu Asp Glu

55 60 65atg att gtg ctg gcc aag gcg gtg acg atc gct acg aag cgt gcg ctt 355Met Ile Val Leu Ala Lys Ala Val Thr Ile Ala Thr Lys Arg Ala Leu 70 75 80 85gtg gtg gtt gat ctg ccg ttt ggt acc tat gag gtg agc cca aat cag 403Val Val Val Asp Leu Pro Phe Gly Thr Tyr Glu Val Ser Pro Asn Gln

90 95 100gcg gtg gag tcc gcg atc cgg gtc atg cgt gaa acg ggt gcg gct gcg 451Ala Val Glu Ser Ala Ile Arg Val Met Arg Glu Thr Gly Ala Ala Ala

105 110 115gtg aag atc gag ggt ggc gtg gag atc gcg cag acg att cga cgc att 499Val Lys Ile Glu Gly Gly Val Glu Ile Ala Gln Thr Ile Arg Arg Ile

120 125 130gtt gat gct gga att ccg gtt gtc ggc cac atc ggg tac acc ccg cag 547Val Asp Ala Gly Ile Pro Val Val Gly His Ile Gly Tyr Thr Pro Gln

135 140 145tcc gag cat tcc ttg ggc ggc cac gtg gtt cag ggt cgt ggc gcg agt 595Ser Glu His Ser Leu Gly Gly His Val Val Gln Gly Arg Gly Ala Ser150 155 160 165tct gga aag ctc atc gcc gat gcc cgc gcg ttg gag cag gcg ggt gcg 643Ser Gly Lys Leu Ile Ala Asp Ala Arg Ala Leu Glu Gln Ala Gly Ala

170 175 180ttt gcg gtt gtg ttg gag atg gtt cca gca gag gca gcg cgc gag gtt 691Phe Ala Val Val Leu Glu Met Val Pro Ala Glu Ala Ala Arg Glu Val

185 190 195acc gag gat ctt tcc atc acc act atc gga atc ggt gcc ggc aat ggc 739Thr Glu Asp Leu Ser Ile Thr Thr Ile Gly Ile Gly Ala Gly Asn Gly

200 205 210aca gat ggg cag gtt ttg gtg tgg cag gat gcc ttc ggc crc aac cgc 787Thr Asp Gly Gln Val Leu Val Trp Gln Asp Ala Phe Gly Leu Asn Arg

215 220 225ggc aag aag cca cgc ttc gtc cgc gag tac gcc acc ttg ggc gat tcc 835Gly Lys Lys Pro Arg Phe Val Arg Glu Tyr Ala Thr Leu Gly Asp Ser230 235 240 245ttg cac gac gcc gcg cag gcc tac atc gcc gat atc cac gcg ggt acc 883Leu His Asp Ala Ala Gln Ala Tyr Ile Ala Asp Ile His Ala Gly Thr

250 255 260ttc cca ggc gaa gcg gag tcc ttt taatgcaggt agcaaccaca aag 930Phe Pro Gly Glu Ala Glu Ser Phe

265<210>618<211>269<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>618Met Ser Gly Ile Asp Ala Lys Lys Ile Arg Thr Arg His Phe Arg Glu 151015 Ala Lys Val Asn Gly Gln Lys Val Ser Val Leu Thr Ser Tyr Asp Ala

20 25 30Leu Ser Ala Arg Ile Phe Asp Glu Ala Gly Val Asp Met Leu Leu Val

35 40 45Gly Asp Ser Ala Ala Asn Val Val Leu Gly Arg Asp Thr Thr Leu Ser

50 55 60Ile Thr Leu Asp Glu Met Ile Val Leu Ala Lys Ala Val Thr Ile Ala 65 70 75 80Thr Lys Arg Ala Leu Val Val Val Asp Leu Pro Phe Gly Thr Tyr Glu

85 90 95Val Ser Pro Asn Gln Ala Val Glu Ser Ala Ile Arg Val Met Arg Glu

100 105 110Thr Gly Ala Ala Ala Val Lys Ile Glu Gly Gly Val Glu Ile Ala Gln

115 120 125Thr Ile Arg Arg Ile Val Asp Ala Gly Ile Pro Val Val Gly His Ile

130 135 140Gly Tyr Thr Pro Gln Ser Glu His Ser Leu Gly Gly His Val Val Gln145 150 155 160Gly Arg Gly Ala Ser Ser Gly Lys Leu Ile Ala Asp Ala Arg Ala Leu

165 170 175Glu Gln Ala Gly Ala Phe Ala Val Val Leu Glu Met Val Pro Ala Glu

180 185 190Ala Ala Arg Glu Val Thr Glu Asp Leu Ser Ile Thr Thr Ile Gly Ile

195 200 205Gly Ala Gly Asn Gly Thr Asp Gly Gln Val Leu Val Trp Gln Asp Ala

210 215 220Phe Gly Leu Asn Arg Gly Lys Lys Pro Arg Phe Val Arg Glu Tyr Ala225 230 235 240Thr Leu Gly Asp Ser Leu His Asp Ala Ala Gln Ala Tyr Ile Ala Asp

245 250 255Ile His Ala Gly Thr Phe Pro Gly Glu Ala Glu Ser Phe

260265<210>619<211>921<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (898)<223>RXA01521<400>619accccggcag gcaacgcctt ttccgggatt tggcgcgcag gcaggcagag atttcccgcg 60cgcaagatat tgagctgtgg gcaattcaga aggaggaccg ttg agt ttc acg cat 115

Leu Ser Phe Thr His

1 5ggt cag ggc aga gtt ttt gat acc gtc gag cag atc cgc atg ttc ggc 163Gly Gln Gly Arg Val Phe Asp Thr Val Glu Gln Ile Arg Met Phe Gly

10 15 20agc gcc ctg cgc aaa acc ggc aaa cca gtg gtg ctc gta ccc ttg gga 211Ser Ala Leu Arg Lys Thr Gly Lys Pro Val Val Leu Val Pro Leu Gly

25 30 35aat ggc ctc cac gca ggc cat att gcg ctc atc cgc gca gca aaa cgc 259Asn Gly Leu His Ala Gly His Ile Ala Leu Ile Arg Ala Ala Lys Arg

40 45 50atc ccc ggt gcg gtg gtc gtc gtc gcc tat gcc ggc ccg gaa tcg gat 307Ile Pro Gly Ala Val Val Val Val Ala Tyr Ala Gly Pro Glu Ser Asp

55 60 65cac gca cgt tta agg gaa gag ctt atc gac gcg atc ttc ccg ttc aat 355His Ala Arg Leu Arg Glu Glu Leu Ile Asp Ala Ile Phe Pro Phe Asn 70 75 80 85ccc gaa acg cta tgg cct cac ggc atc cgg gtg gaa gtt aca ggt ggc 403Pro Glu Thr Leu Trp Pro His Gly Ile Arg Val Glu Val Thr Gly Gly

90 95 100cca aca ctt acc cca caa ggt gcg gaa gta acc aag gtg ctg ggg ctg 451Pro Thr Leu Thr Pro Gln Gly Ala Glu Val Thr Lys Val Leu Gly Leu

105 110 115ttg gga atc acc gga gca act gat gtg gtg ctc ggt gaa aag gac tat 499Leu Gly Ile Thr Gly Ala Thr Asp Val Val Leu Gly Glu Lys Asp Tyr

120 125 130gag ctg gtg gtt cta gtc cag cgc gcc ctt aat gat ctg cat att cca 547Glu Leu Val Val Leu Val Gln Arg Ala Leu Asn Asp Leu His Ile Pro

135 140 145gta aaa ctg cat tct gtt cca acc gtg cgc atg cca gat gga cta gcc 595Val Lys Leu His Ser Val Pro Thr Val Arg Met Pro Asp Gly Leu Ala150 155 160 165att tcc ctg cgt aat att tca gtg ccc gaa gac tcc cgc gaa acg gca 643Ile Ser Leu Arg Asn Ile Ser Val Pro Glu Asp Ser Arg Glu Thr Ala

170 175 180ttg agc ctg gca gca gcc ctc acc gcc ggt gcg cat tcg gca gaa cac 691Leu Ser Leu Ala Ala Ala Leu Thr Ala Gly Ala His Ser Ala Glu His

185 190 195ggc gag gca gtg gtt aaa gaa aca gtc acg caa gtg ctc aaa gcc gca 739Gly Glu Ala Val Val Lys Glu Thr Val Thr Gln Val Leu Lys Ala Ala

200 205 210ggc gtg acc ccc gat tat gta gaa atc cgt ggc ctg gat ctt gga cca 787Gly Val Thr Pro Asp Tyr Val Glu Ile Arg Gly Leu Asp Leu Gly Pro

215 220 225gcc ccc gaa atc gga gac gcc cga ctc ttc gca gcc atc acg ctt ggc 835Ala Pro Glu Ile Gly Asp Ala Arg Leu Phe Ala Ala Ile Thr Leu Gly230 235 240 245gat gtc caa ctc cac gac aac gtc ggc cta ccc ctt gga atc ggc ttc 883Asp Val Gln Leu His Asp Asn Val Gly Leu Pro Leu Gly Ile Gly Phe

250 255 260aaa aac atc gaa ggc tgatcccggt ttacccagtt cgc 921Lys Asn Ile Glu Gly

265<210>620<211>266<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>620Leu Ser Phe Thr His Gly Gln Gly Arg Val Phe Asp Thr Val Glu Gln 151015 Ile Arg Met Phe Gly Ser Ala Leu Arg Lys Thr Gly Lys Pro Val Val

20 25 30Leu Val Pro Leu Gly Asn Gly Leu His Ala Gly His Ile Ala Leu Ile

35 40 45Arg Ala Ala Lys Arg Ile Pro Gly Ala Val Val Val Val Ala Tyr Ala

5055 60Gly Pro Glu Ser Asp His Ala Arg Leu Arg Glu Glu Leu Ile Asp Ala 65 70 75 80Ile Phe Pro Phe Asn Pro Glu Thr Leu Trp Pro His Gly Ile Arg Val

85 90 95Glu Val Thr Gly Gly Pro Thr Leu Thr Pro Gln Gly Ala Glu Val Thr

100 105 110Lys Val Leu Gly Leu Leu Gly Ile Thr Gly Ala Thr Asp Val Val Leu

115 120 125Gly Glu Lys Asp Tyr Glu Leu Val Val Leu Val Gln Arg Ala Leu Asn

130 135 140Asp Leu His Ile Pro Val Lys Leu His Ser Val Pro Thr Val Arg Met145 150 155 160Pro Asp Gly Leu Ala Ile Ser Leu Arg Asn Ile Ser Val Pro Glu Asp

165 170 175Ser Arg Glu Thr Ala Leu Ser Leu Ala Ala Ala Leu Thr Ala Gly Ala

180 185 190His Ser Ala Glu His Gly Glu Ala Val Val Lys Glu Thr Val Thr Gln

195 200 205Val Leu Lys Ala Ala Gly Val Thr Pro Asp Tyr Val Glu Ile Arg Gly

210 215 220Leu Asp Leu Gly Pro Ala Pro Glu Ile Gly Asp Ala Arg Leu Phe Ala225 230 235 240Ala Ile Thr Leu Gly Asp Val Gln Leu His Asp Asn Val Gly Leu Pro

245 250 255Leu Gly Ile Gly Phe Lys Asn Ile Glu Gly

260265<210>621<211>1137<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1114)<223>RXS01145<400>621taatgtagtt gtctgcccaa gcgagttaaa ctcccacgat ttacagtggg gggcagacat 60cttttcacca aaatttttac gaaaggcgag attttctccc atg gct att gaa ctg 115

Met Ala Ile Glu Leu

1 5ctt tat gat gct gac gct gac ctc tcc ttg atc cag ggc cgt aag gtt 163Leu Tyr Asp Ala Asp Ala Asp Leu Ser Leu Ile Gln Gly Arg Lys Val

10 15 20gcc atc gtt ggc tac ggc tcc cag ggc cac gca cac tcc cag aac ctc 211Ala Ile Val Gly Tyr Gly Ser Gln Gly His Ala His Ser Gln Asn Leu

25 30 35cgc gat tct ggc gtt gag gtt gtc att ggt ctg cgc gag ggc tcc aag 259Arg Asp Ser Gly Val Glu Val Val Ile Gly Leu Arg Glu Gly Ser Lys

40 45 50tcc gca gag aag gca aag gaa gca ggc ttc gag gtc aag acc acc gct 307Ser Ala Glu Lys Ala Lys Glu Ala Gly Phe Glu Val Lys Thr Thr Ala

55 60 65gag gct gca gct tgg gct gac gtc atc atg ctc ctg gct cca gac acc 355Glu Ala Ala Ala Trp Ala Asp Val Ile Met Leu Leu Ala Pro Asp Thr 70 75 80 85tcc cag gca gaa atc ttc acc aac gac atc gag cca aac ctg aac gca 403Ser Gln Ala Glu Ile Phe Thr Asn Asp Ile Glu Pro Asn Leu Asn Ala

90 95 100ggc gac gca ctg ctg ttc ggc cac ggc ctg aac att cac ttc gac ctg 451Gly Asp Ala Leu Leu Phe Gly His Gly Leu Asn Ile His Phe Asp Leu

105 110 115atc aag cca gct gac gac atc atc gtt ggc atg gtt gcg cca aag ggc 499Ile Lys Pro Ala Asp Asp Ile Ile Val Gly Met Val Ala Pro Lys Gly

120 125 130cca ggc cac ttg gtt cgc cgt cag ttc gtt gat ggc aag ggt gtt cct 547Pro Gly His Leu Val Arg Arg Gln Phe Val Asp Gly Lys Gly Val Pro

135 140 145tgc ctc atc gca gtc gac cag gac cca acc gga acc gca cag gct ctg 595Cys Leu Ile Ala Val Asp Gln Asp Pro Thr Gly Thr Ala Gln Ala Leu150 155 160 165acc ctg tcc tac gca gca gca atc ggt ggc gca cgc gca ggc gtt atc 643Thr Leu Ser Tyr Ala Ala Ala Ile Gly Gly Ala Arg Ala Gly Val Ile

170 175 180cca acc acc ttc gaa gct gag acc gtc acc gac ctc ttc ggc gag cag 691Pro Thr Thr Phe Glu Ala Glu Thr Val Thr Asp Leu Phe Gly Glu Gln

185 190 195gct gtt ctc tgc ggt ggc acc gag gaa ctg gtc aag gtt ggc ttc gag 739Ala Val Leu Cys Gly Gly Thr Glu Glu Leu Val Lys Val Gly Phe Glu

200 205 210gtt ctc acc gaa gct ggc tac gag cca gag atg gca tac ttc gag gtt 787Val Leu Thr Glu Ala Gly Tyr Glu Pro Glu Met Ala Tyr Phe Glu Val

215 220 225ctt cac gag ctc aag ctc atc gtt gac ctc atg ttc gaa ggt ggc atc 835Leu His Glu Leu Lys Leu Ile Val Asp Leu Met Phe Glu Gly Gly Ile230 235 240 245agc aac atg aac tac tct gtt tct gac acc gct gag ttc ggt ggc tac 883Ser Asn Met Asn Tyr Ser Val Ser Asp Thr Ala Glu Phe Gly Gly Tyr

250 255 260ctc tcc ggc cca cgc gtc atc gat gca gac acc aag tcc cgc atg aag 931Leu Ser Gly Pro Arg Val Ile Asp Ala Asp Thr Lys Ser Arg Met Lys

265 270 275gac atc ctg acc gat atc cag gac ggc acc ttc acc aag cgc ctc atc 979Asp Ile Leu Thr Asp Ile Gln Asp Gly Thr Phe Thr Lys Arg Leu Ile

280 285 290gca aac gtt gag aac ggc aac acc gag ctt gag ggc ctt cgt gct tcc 1027Ala Asn Val Glu Asn Gly Asn Thr Glu Leu Glu Gly Leu Arg Ala Ser

295 300 305tac aac aac cac cca atc gag gag acc ggc gct aag ctc cgc gac ctc 1075Tyr Asn Asn His Pro Ile Glu Glu Thr Gly Ala Lys Leu Arg Asp Leu310 315 320 325atg agc tgg gtc aag gtt gac gct cgc gca gaa acc gct taagtttcac 1124Met Ser Trp Val Lys Val Asp Ala Arg Ala Glu Thr Ala

330335 ccctttgacg gct 1137<210>622<211>338<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>622Met Ala Ile Glu Leu Leu Tyr Asp Ala Asp Ala Asp Leu Ser Leu Ile 151015 Gln Gly Arg Lys Val Ala Ile Val Gly Tyr Gly Ser Gln Gly His Ala

20 25 30His Ser Gln Asn Leu Arg Asp Ser Gly Val Glu Val Val Ile Gly Leu

35 40 45Arg Glu Gly Ser Lys Ser Ala Glu Lys Ala Lys Glu Ala Gly Phe Glu

50 55 60Val Lys Thr Thr Ala Glu Ala Ala Ala Trp Ala Asp Val Ile Met Leu 65 70 75 80Leu Ala Pro Asp Thr Ser Gln Ala Glu Ile Phe Thr Asn Asp Ile Glu

85 90 95Pro Asn Leu Asn Ala Gly Asp Ala Leu Leu Phe Gly His Gly Leu Asn

100 105 110Ile His Phe Asp Leu Ile Lys Pro Ala Asp Asp Ile Ile Val Gly Met

115 120 125Val Ala Pro Lys Gly Pro Gly His Leu Val Arg Arg Gln Phe Val Asp

130 135 140Gly Lys Gly Val Pro Cys Leu Ile Ala Val Asp Gln Asp Pro Thr Gly145 150 155 160Thr Ala Gln Ala Leu Thr Leu Ser Tyr Ala Ala Ala Ile Gly Gly Ala

165 170 175Arg Ala Gly Val Ile Pro Thr Thr Phe Glu Ala Glu Thr Val Thr Asp

180 185 190Leu Phe Gly Glu Gln Ala Val Leu Cys Gly Gly Thr Glu Glu Leu Val

195 200 205Lys Val Gly Phe Glu Val Leu Thr Glu Ala Gly Tyr Glu Pro Glu Met

210 215 220Ala Tyr Phe Glu Val Leu His Glu Leu Lys Leu Ile Val Asp Leu Met225 230 235 240Phe Glu Gly Gly Ile Ser Asn Met Asn Tyr Ser Val Ser Asp Thr Ala

245 250 255Glu Phe Gly Gly Tyr Leu Ser Gly Pro Arg Val Ile Asp Ala Asp Thr

260 265 270Lys Ser Arg Met Lys Asp Ile Leu Thr Asp Ile Gln Asp Gly Thr Phe

275 280 285Thr Lys Arg Leu Ile Ala Asn Val Glu Asn Gly Asn Thr Glu Leu Glu

290 295 300Gly Leu Arg Ala Ser Tyr Asn Asn His Pro Ile Glu Glu Thr Gly Ala305 310 315 320Lys Leu Arg Asp Leu Met Ser Trp Val Lys Val Asp Ala Arg Ala Glu

325330335 Thr Ala<210>623<211>556<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (556)<223>FRXA01145<400>623taatgtagtt gtctgcccaa gcgagttaaa ctcccacgat ttacagtggg gggcagacat 60cttttcacca aaatttttac gaaaggcgag attttctccc atg gct att gaa ctg 115

Met Ala Ile Glu Leu

1 5ctt tat gat gct gac gct gac ctc tcc ttg atc cag ggc cgt aag gtt 163Leu Tyr Asp Ala Asp Ala Asp Leu Ser Leu Ile Gln Gly Arg Lys Val

10 15 20gcc atc gtt ggc tac ggc tcc cag ggc cac gca cac tcc cag aac ctc 211Ala Ile Val Gly Tyr Gly Ser Gln Gly His Ala His Ser Gln Asn Leu

25 30 35cgc gat tct ggc gtt gag gtt gtc att ggt ctg cgc gag ggc tcc aag 259Arg Asp Ser Gly Val Glu Val Val Ile Gly Leu Arg Glu Gly Ser Lys

40 45 50tcc gca gag aag gca aag gaa gca ggc ttc gag gtc aag acc acc gct 307Ser Ala Glu Lys Ala Lys Glu Ala Gly Phe Glu Val Lys Thr Thr Ala

55 60 65gag gct gca gct tgg gct gac gtc atc atg ctc ctg gct cca gac acc 355Glu Ala Ala Ala Trp Ala Asp Val Ile Met Leu Leu Ala Pro A sp Thr 70 75 80 85tcc cag gca gaa atc ttc acc aac gac atc gag cca aac ctg aac gca 403Ser Gln Ala Glu Ile Phe Thr Asn Asp Ile Glu Pro Asn Leu Asn Ala

90 95 100ggc gac gca ctg ctg ttc ggc cac ggc ctg aac att cac ttc gac ctg 451Gly Asp Ala Leu Leu Phe Gly His Gly Leu Asn Ile His Phe Asp Leu

105 110 115atc aag cca gct gac gac atc atc gtt ggc atg gtt gcg cca aag ggc 499Ile Lys Pro Ala Asp Asp Ile Ile Val Gly Met Val Ala Pro Lys Gly

120 125 130cca ggc cac ttg gtt cgc cgt cag ttc gtt gat ggc aag ggt gtt cct 547Pro Gly His Leu Val Arg Arg Gln Phe Val Asp Gly Lys Gly Val Pro

135140145 tgc ctc atc 556Cys Leu Ile150<210>624<211>152<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>624Met Ala Ile Glu Leu Leu Tyr Asp Ala Asp Ala Asp Leu Ser Leu Ile 151015 Gln Gly Arg Lys Val Ala Ile Val Gly Tyr Gly Ser Gln Gly His Ala

20 25 30His Ser Gln Asn Leu Arg Asp Ser Gly Val Glu Val Val Ile Gly Leu

35 40 45Arg Glu Gly Ser Lys Ser Ala Glu Lys Ala Lys Glu Ala Gly Phe Glu

50 55 60Val Lys Thr Thr Ala Glu Ala Ala Ala Trp Ala Asp Val Ile Met Leu65 70 75 80Leu Ala Pro Asp Thr Ser Gln Ala Glu Ile Phe Thr Asn Asp Ile Glu

85 90 95Pro Asn Leu Asn Ala Gly Asp Ala Leu Leu Phe Gly His Gly Leu Asn

100 105 110Ile His Phe Asp Leu Ile Lys Pro Ala Asp Asp Ile Ile Val Gly Met

115 120 125Val Ala Pro Lys Gly Pro Gly His Leu Val Arg Arg Gln Phe Val Asp

130135140 Gly Lys Gly Val Pro Cys Leu Ile 145150<210>625<211>1389<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220>CDS<222>(101).)

Val Pro Met Thr His

1 5gtt tca agc ccc tcc gca ccc cgc aac gtg gtt gtt ggt gtt gcc ggc 163Val Ser Ser Pro Ser Ala Pro Arg Asn Val Val Val Gly Val Ala Gly

10 15 20gga atc gca gcg tac aag gcg tgt cac atc gtg cgc gcg ttt aaa gaa 211Gly Ile Ala Ala Tyr Lys Ala Cys His Ile Val Arg Ala Phe Lys Glu

25 30 35gcg ggc gat aat gtg cgg gtg gtt cct acg gaa tcc gcg ttg aag ttt 259Ala Gly Asp Asn Val Arg Val Val Pro Thr Glu Ser Ala Leu Lys Phe

40 45 50gtg ggg aag gcg acg ttt gaa gcg ttg tct ggc aat ccg gtg tct aca 307Val Gly Lys Ala Thr Phe Glu Ala Leu Ser Gly Asn Pro Val Ser Thr

55 60 65acg gtg ttt gat gcg gtg gat tcg gtg cag cat gtg aaa gtt ggc cag 355Thr Val Phe Asp Ala Val Asp Ser Val Gln His Val Lys Val Gly Gln 70 75 80 85gaa gct gat ttg atc gtg att gcg ccg gcg aca gcc gat ttg atg gcg 403Glu Ala Asp Leu Ile Val Ile Ala Pro Ala Thr Ala Asp Leu Met Ala

90 95 100cgt gtg gtg gca ggt ctc ggt gac gat ctg ttg gcg gcg acg ctg ctg 451Arg Val Val Ala Gly Leu Gly Asp Asp Leu Leu Ala Ala Thr Leu Leu

105 110 115gtg gca acg tgc ccc gtg gtt att gcg ccg gcc atg cat acg gag atg 499Val Ala Thr Cys Pro Val Val Ile Ala Pro Ala Met His Thr Glu Met

120 125 130tgg ttt aat ccg gct acc gta gcc aat gtg gca acg ctg agg cag cgg 547Trp Phe Asn Pro Ala Thr Val Ala Asn Val Ala Thr Leu Arg Gln Arg

135 140 145ggg att acc gtg att gag cct gcg cat ggt cga ctc acc ggt aaa gat 595Gly Ile Thr Val Ile Glu Pro Ala His Gly Arg Leu Thr Gly Lys Asp150 155 160 165aca ggc cct ggc cgg ctg ccg gat cca gag cag att gtt gat tta gcc 643Thr Gly Pro Gly Arg Leu Pro Asp Pro Glu Gln Ile Val Asp Leu Ala

170 175 180aat gcg gtg cac gcc ggg gcg agg ttg cct cag gat ttg gcg ggc aag 691Asn Ala Val His Ala Gly Ala Arg Leu Pro Gln Asp Leu Ala Gly Lys

185 190 195aaa gtg ctg atc act gct ggt ggc acg cat gag cat att gat cct gtg 739Lys Val Leu Ile Thr Ala Gly Gly Thr His Glu His Ile Asp Pro Val

200 205 210cgc ttt att ggc aat agt tcc tcg ggc cgt caa ggt ttt gcg ttg ggt 787Arg Phe Ile Gly Asn Ser Ser Ser Gly Arg Gln Gly Phe Ala Leu Gly

215 220 225gaa atc gca gca cag cga ggt gct cat gtc agc atc gtg gcg gga aat 835Glu Ile Ala Ala Gln Arg Gly Ala His Val Ser Ile Val Ala Gly Asn230 235 240 245gct gcg gag ctg ccc act ccg gca ggc gca gag atc gtg ccg gtg gtg 883Ala Ala Glu Leu Pro Thr Pro Ala Gly Ala Glu Ile Val Pro Val Val

250 255 260tcc aca caa gac atg ttt gat gca gtc cag gaa cga gct ggc caa tct 931Ser Thr Gln Asp Met Phe Asp Ala Val Gln Glu Arg Ala Gly Gln Ser

265 270 275gat ttc atc gtc atg gcg gca gcg gta gct gat ttc acg ccc gca tcg 979Asp Phe Ile Val Met Ala Ala Ala Val Ala Asp Phe Thr Pro Ala Ser

280 285 290cag gcg aca tcg aag ttg aag aag ggc tca gat tct gat gaa gac gca 1027Gln Ala Thr Ser Lys Leu Lys Lys Gly Ser Asp Ser Asp Glu Asp Ala

295 300 305ttg agc accatc tcg ttg gtg gaa aac ccg gat att ttg gct acc acg 1075Leu Ser Thr Ile Ser Leu Val Glu Asn Pro Asp Ile Leu Ala Thr Thr310 315 320 325gtg aag cgt cgt gaa gca gga gag ctg gac agt aat cct gtc atc gtg 1123Val Lys Arg Arg Glu Ala Gly Glu Leu Asp Ser Asn Pro Val Ile Val

330 335 340ggt ttt gct gcg gaa act gga gac gag cac acc acc gcc ttg gag tat 1171Gly Phe Ala Ala Glu Thr Gly Asp Glu His Thr Thr Ala Leu Glu Tyr

345 350 355gcg cgc aag aaa ctg cag aag aag ggc tgc gac ctc ctc atg tgt aat 1219Ala Arg Lys Lys Leu Gln Lys Lys Gly Cys Asp Leu Leu Met Cys Asn

360 365 370gag gtg ggc atg ggc aaa gtg ttt ggg caa aag cac aat gag ggc tgg 1267Glu Val Gly Met Gly Lys Val Phe Gly Gln Lys His Asn Glu Gly Trp

375 380 385att ttg gat gct cac ggt ggg gta gtc gat gtg gag cac ggc agc aaa 1315Ile Leu Asp Ala His Gly Gly Val Val Asp Val Glu His Gly Ser Lys390 395 400 405atc gag gtt gct gcg caa att tgg gac gcg gca ctg gcg tat cgc gaa 1363Ile Glu Val Ala Ala Gln Ile Trp Asp Ala Ala Leu Ala Tyr Arg Glu

410415420 gtc tagaaaaatc cagctagacc act 1389Val<210>626<211>422<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>626Val Pro Met Thr His Val Ser Ser Pro Ser Ala Pro Arg Asn Val Val 151015 Val Gly Val Ala Gly Gly Ile Ala Ala Tyr Lys Ala Cys His Ile Val

20 25 30Arg Ala Phe Lys Glu Ala Gly Asp Asn Val Arg Val Val Pro Thr Glu

35 40 45Ser Ala Leu Lys Phe Val Gly Lys Ala Thr Phe Glu Ala Leu Ser Gly

50 55 60Asn Pro Val Ser Thr Thr Val Phe Asp Ala Val Asp Ser Val Gln His 65 70 75 80Val Lys Val Gly Gln Glu Ala Asp Leu Ile Val Ile Ala Pro Ala Thr

85 90 95Ala Asp Leu Met Ala Arg Val Val Ala Gly Leu Gly Asp Asp Leu Leu

100 105 110Ala Ala Thr Leu Leu Val Ala Thr Cys Pro Val Val Ile Ala Pro Ala

115 120 125Met His Thr Glu Met Trp Phe Asn Pro Ala Thr Val Ala Asn Val Ala

130 135 140Thr Leu Arg Gln Arg Gly Ile Thr Val Ile Glu Pro Ala His Gly Arg145 150 155 160Leu Thr Gly Lys Asp Thr Gly Pro Gly Arg Leu Pro Asp Pro Glu Gln

165 170 175Ile Val Asp Leu Ala Asn Ala Val His Ala Gly Ala Arg Leu Pro Gln

180 185 190Asp Leu Ala Gly Lys Lys Val Leu Ile Thr Ala Gly Gly Thr His Glu

195 200 205His Ile Asp Pro Val Arg Phe Ile Gly Asn Ser Ser Ser Gly Arg Gln

210 215 220Gly Phe Ala Leu Gly Glu Ile Ala Ala Gln Arg Gly Ala His Val Ser225 230 235 240Ile Val Ala Gly Asn Ala Ala Glu Leu Pro Thr Pro Ala Gly Ala Glu

245 250 255Ile Val Pro Val Val Ser Thr Gln Asp Met Phe Asp Ala Val Gln Glu

260 265 270Arg Ala Gly Gln Ser Asp Phe Ile Val Met Ala Ala Ala Val Ala Asp

275 280 285Phe Thr Pro Ala Ser Gln Ala Thr Ser Lys Leu Lys Lys Gly Ser Asp

290 295 300Ser Asp Glu Asp Ala Leu Ser Thr Ile Ser Leu Val Glu Asn Pro Asp305 310 315 320Ile Leu Ala Thr Thr Val Lys Arg Arg Glu Ala Gly Glu Leu Asp Ser

325 330 335Asn Pro Val Ile Val Gly Phe Ala Ala Glu Thr Gly Asp Glu His Thr

340 345 350Thr Ala Leu Glu Tyr Ala Arg Lys Lys Leu Gln Lys Lys Gly Cys Asp

355 360 365Leu Leu Met Cys Asn Glu Val Gly Met Gly Lys Val Phe Gly Gln Lys

370 375 380His Asn Glu Gly Trp Ile Leu Asp Ala His Gly Gly Val Val Asp Val385 390 395 400Glu His Gly Ser Lys Ile Glu Val Ala Ala Gln Ile Trp Asp Ala Ala

405 410 415Leu Ala Tyr Arg Glu Val

420<210>627<211>1092<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1069)<223>RXA00581<400>627gcatgagttt actcacgtgc ccacgtcttt tagccaccca ttgaagtgaa aaaataaccc 60cgatcacact agtggagtag ctaaggtgca caatggattc atg gca gag caa aac 115

Met Ala Glu Gln Asn

1 5gct gca agc aca act ggt gtg aaa cct tcc cca cgc aca cca gat ttc 163Ala Ala Ser Thr Thr Gly Val Lys Pro Ser Pro Arg Thr Pro Asp Phe

10 15 20agc ccc tac ctt gat ttc gac cgc gca caa tgg cgc gag ctg aga aac 211Ser Pro Tyr Leu Asp Phe Asp Arg Ala Gln Trp Arg Glu Leu Arg Asn

25 30 35tca atg cct cag gtg ctg acc caa aaa gaa gtc att gaa ctt cga ggc 259Ser Met Pro Gln Val Leu Thr Gln Lys Glu Val Ile Glu Leu Arg Gly

40 45 50atc gga gaa aac att gac ctc gct gaa gtg gca gaa gtc tac ctt ccg 307Ile Gly Glu Asn Ile Asp Leu Ala Glu Val Ala Glu Val Tyr Leu Pro

55 60 65ctg tcc cgt ctg att cac ctc cag gta gcg gcc cga cag caa ctt act 355Leu Ser Arg Leu Ile His Leu Gln Val Ala Ala Arg Gln Gln Leu Thr 70 75 80 85gca gcc acc gaa acc ttc ctc gga act tcc ccc tct atc tct gtg ccg 403Ala Ala Thr Glu Thr Phe Leu Gly Thr Ser Pro Ser Ile Ser Val Pro

90 95 100ttt gtc att ggt gtc gcg gga tcc gtc gcc gtc ggt aaa tca acc acc 451Phe Val Ile Gly Val Ala Gly Ser Val Ala Val Gly Lys Ser Thr Thr

105 110 115gcc cga ctc ctc caa gtt ctg ctt cag cgc tgg aat tcc cac ccc cgc 499Ala Arg Leu Leu Gln Val Leu Leu Gln Arg Trp Asn Ser His Pro Arg

120 125 130gtg gac ctc gtc acc acc gac gga ttc ctc tat ccc ggc gcg gaa cta 547Val Asp Leu Val Thr Thr Asp Gly Phe Leu Tyr Pro Gly Ala Glu Leu

135 140 145atc cgc cgc gga tta atg tcc cga aaa gga ttc ccc gaa agc tac gac 595Ile Arg Arg Gly Leu Met Ser Arg Lys Gly Phe Pro Glu Ser Tyr Asp150 155 160 165caa cgt gca ctc ctc cgc ttt gtc acc gac gta aaa tcc gga aaa ctc 643Gln Arg Ala Leu Leu Arg Phe Val Thr Asp Val Lys Ser Gly Lys Leu

170 175 180gaa gtc aac gca cct gtc tac tcc cac acc gcg tac gac cga gtt cca 691Glu Val Asn Ala Pro Val Tyr Ser His Thr Ala Tyr Asp Arg Val Pro

185 190 195ggc gaa ttc acc aca gtc cgc caa ccc gac att ttg atc gtc gaa ggc 739Gly Glu Phe Thr Thr Val Arg Gln Pro Asp Ile Leu Ile Val Glu Gly

200 205 210tta aac gtc ctc caa act ggc cca aca ttg atg gtc agt gac ctt ttc 787Leu Asn Val Leu Gln Thr Gly Pro Thr Leu Met Val Ser Asp Leu Phe

215 220 225gac ttc agc gtc tac gta gat gcc cgc acc gaa gat atc gaa aaa tgg 835Asp Phe Ser Val Tyr Val Asp Ala Arg Thr Glu Asp Ile Glu Lys Trp230 235 240 245tac atc gac cgc ttc ctc aaa ctc cgc gac act gca ttc cgt cgc ccc 883Tyr Ile Asp Arg Phe Leu Lys Leu Arg Asp Thr Ala Phe Arg Arg Pro

250 255 260ggt gcc cac ttc tcc cat tac gcc gac atg gct gat cca gag tcc atc 931Gly Ala His Phe Ser His Tyr Ala Asp Met Ala Asp Pro Glu Ser Ile

265 270 275gcc gtc gct cga gaa ctg tgg caa tcg atc aac ctg ccc aac ttg gtg 979Ala Val Ala Arg Glu Leu Trp Gln Ser Ile Asn Leu Pro Asn Leu Val

280 285 290gag aat att ctt ccc acc cga gtt cgc gcg tcg ttg gta ctg aaa aaa 1027Glu Asn Ile Leu Pro Thr Arg Val Arg Ala Ser Leu Val Leu Lys Lys

295300305 ggt agc gat cac ttg gtg gaa cgg gtg agg atg cgc aag atc 1069Gly Ser Asp His Leu Val Glu Arg Val Arg Met Arg Lys Ile 310315320 tagggttct tgctggtttt gag 1092<210>628<211>323<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>628Met Ala Glu Gln Asn Ala Ala Ser Thr Thr Gly Val Lys Pro Ser Pro 151015 Arg Thr Pro Asp Phe Ser Pro Tyr Leu Asp Phe Asp Arg Ala Gln Trp

20 25 30Arg Glu Leu Arg Asn Ser Met Pro Gln Val Leu Thr Gln Lys Glu Val

35 40 45Ile Glu Leu Arg Gly Ile Gly Glu Asn Ile Asp Leu Ala Glu Val Ala

50 55 60Glu Val Tyr Leu Pro Leu Ser Arg Leu Ile His Leu Gln Val Ala Ala 65 70 75 80Arg Gln Gln Leu Thr Ala Ala Thr Glu Thr Phe Leu Gly Thr Ser Pro

85 90 95Ser Ile Ser Val Pro Phe Val Ile Gly Val Ala Gly Ser Val Ala Val

100 105 110Gly Lys Ser Thr Thr Ala Arg Leu Leu Gln Val Leu Leu Gln Arg Trp

115 120 125Asn Ser His Pro Arg Val Asp Leu Val Thr Thr Asp Gly Phe Leu Tyr

130 135 140Pro Gly Ala Glu Leu Ile Arg Arg Gly Leu Met Ser Arg Lys Gly Phe145 150 155 160Pro Glu Ser Tyr Asp Gln Arg Ala Leu Leu Arg Phe Val Thr Asp Val

165 170 175Lys Ser Gly Lys Leu Glu Val Asn Ala Pro Val Tyr Ser His Thr Ala

180 185 190Tyr Asp Arg Val Pro Gly Glu Phe Thr Thr Val Arg Gln Pro Asp Ile

195 200 205Leu Ile Val Glu Gly Leu Asn Val Leu Gln Thr Gly Pro Thr Leu Met

210 215 220Val Ser Asp Leu Phe Asp Phe Ser Val Tyr Val Asp Ala Arg Thr Glu225 230 235 240Asp Ile Glu Lys Trp Tyr Ile Asp Arg Phe Leu Lys Leu Arg Asp Thr

245 250 255Ala Phe Arg Arg Pro Gly Ala His Phe Ser His Tyr Ala Asp Met Ala

260 265 270Asp Pro Glu Ser Ile Ala Val Ala Arg Glu Leu Trp Gln Ser Ile Asn

275 280 285Leu Pro Asn Leu Val Glu Asn Ile Leu Pro Thr Arg Val Arg Ala Ser

290295300 Leu Val Leu Lys Lys Gly Ser Asp His Leu Val Glu Arg Val Arg Met 305310315320 Arg Lys Ile<210>629<211>1023<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1000)<223>RXS00838<400>629tcgtctaata gtgctgccaa tccaccggcc attgatgact cctttgtaga gaaggggtag 60tgcttacaaa tcttatctgt gctcaggcaa gatagcaggt atg aaa att gcg atc 115

Met Lys Ile Ala Ile

1 5gtt ggc gct ggt gca gtt ggt gga tat ttc gga gcg ttg tta caa gaa 163Val Gly Ala Gly Ala Val Gly Gly Tyr Phe Gly Ala Leu Leu Gln Glu

10 15 20tct ggt gca gat ate acg atg gtt gca cgt gga cga aca tta gaa gcc 211Ser Gly Ala Asp Ile Thr Met Val Ala Arg Gly Arg Thr Leu Glu Ala

25 30 35ttg aag tct aaa gga ctc cac atc aac gat gca aga ggc gaa cgc tac 259Leu Lys Ser Lys Gly Leu His Ile Asn Asp Ala Arg Gly Glu Arg Tyr

4045 50gta cca att cct gca gtt gcg agc gtg caa gaa cta aaa gat gca gat 307Val Pro Ile Pro Ala Val Ala Ser Val Gln Glu Leu Lys Asp Ala Asp

55 60 65gta gtg atg att gct act aaa gca tta tcg cgg tct tta gat ctc gct 355Val Val Met Ile Ala Thr Lys Ala Leu Ser Arg Ser Leu Asp Leu Ala 70 75 80 85gaa ctt ttg ggt ggg ata cct gcg aat tcg gtg gtc gcg att act cag 403Glu Leu Leu Gly Gly Ile Pro Ala Asn Ser Val Val Ala Ile Thr Gln

90 95 100aat tcg att gaa tct gct gat cta gca gcg aag agt atc ggt gct gat 451Asn Ser Ile Glu Ser Ala Asp Leu Ala Ala Lys Ser Ile Gly Ala Asp

105 110 115cgt gtg tgg cct ggt gtg gtt cgt ggg ttc ttt gtt cat gag ggg cca 499Arg Val Trp Pro Gly Val Val Arg Gly Phe Phe Val His Glu Gly Pro

120 125 130gcc tca gtg tca tac aag gga ggc cca ctg tcc tac acg ttt ggt gat 547Ala Ser Val Ser Tyr Lys Gly Gly Pro Leu Ser Tyr Thr Phe Gly Asp

135 140 145tct ggt gaa ctt tct agg caa ttc gca agc act ctt gaa cag gcc ggt 595Ser Gly Glu Leu Ser Arg Gln Phe Ala Ser Thr Leu Glu Gln Ala Gly150 155 160 165att gac gga gtt ctg cat ccc gat att ttg gtg gat gtg tgg gag aaa 643Ile Asp Gly Val Leu His Pro Asp Ile Leu Val Asp Val Trp Glu Lys

170 175 180gcc atg ttc gta gag gtt ttc ggc ggg ttg ggg gct ttc gtc gaa aag 691Ala Met Phe Val Glu Val Phe Gly Gly Leu Gly Ala Phe Val Glu Lys

185 190 195caa tta ggt acc ttg cgt acg cat ttt agg gct tcc ctg gaa gcc ttg 739Gln Leu Gly Thr Leu Arg Thr His Phe Arg Ala Ser Leu Glu Ala Leu

200 205 210atg gaa gag gtg gct gag gtg gct cgc gcg gca ggt gtt gcg ttg ccg 787Met Glu Glu Val Ala Glu Val Ala Arg Ala Ala Gly Val Ala Leu Pro

215 220 225agc gat gcg gtg gag cgc acc atg aat ttt gcg gat cgg atg cct gag 835Ser Asp Ala Val Glu Arg Thr Met Asn Phe Ala Asp Arg Met Pro Glu230 235 240 245aat tcg acg agt tcg atg cag cgt gat ttg gcc gcg gga gtg gct agt 883Asn Ser Thr Ser Ser Met Gln Arg Asp Leu Ala Ala Gly Val Ala Ser

250 255 260gag ctt gag gct cag aca ggt gca att gtg cgg gca gcg cac aaa gtg 931Glu Leu Glu Ala Gln Thr Gly Ala Ile Val Arg Ala Ala His Lys Val

265 270 275ggt gtg aaa act ccg ctt cat gac ctt att tat gct ggt ctt aag ctg 979Gly Val Lys Thr Pro Leu His Asp Leu Ile Tyr Ala Gly Leu Lys Leu

280 285 290aaa gaa gag gaa aat tca ctt tagggataga atcaagatcc atg 1023Lys Glu Glu Glu Asn Ser Leu

295300<210>630<211>300<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>630Met Lys Ile Ala Ile Val Gly Ala Gly Ala Val Gly Gly Tyr Phe Gly 151015 Ala Leu Leu Gln Glu Ser Gly Ala Asp Ile Thr Met Val Ala Arg Gly

20 25 30Arg Thr Leu Glu Ala Leu Lys Ser Lys Gly Leu His Ile Asn Asp Ala

35 40 45Arg Gly Glu Arg Tyr Val Pro Ile Pro Ala Val Ala Ser Val Gln Glu

50 55 60Leu Lys Asp Ala Asp Val Val Met Ile Ala Thr Lys Ala Leu Ser Arg 65 70 75 80Ser Leu Asp Leu Ala Glu Leu Leu Gly Gly Ile Pro Ala Asn Ser Val

85 90 95Val Ala Ile Thr Gln Asn Ser Ile Glu Ser Ala Asp Leu Ala Ala Lys

100 105 110Ser Ile Gly Ala Asp Arg Val Trp Pro Gly Val Val Arg Gly Phe Phe

115 120 125Val His Glu Gly Pro Ala Ser Val Ser Tyr Lys Gly Gly Pro Leu Ser

130 135 140Tyr Thr Phe Gly Asp Ser Gly Glu Leu Ser Arg Gln Phe Ala Ser Thr145 150 155 160Leu Glu Gln Ala Gly Ile Asp Gly Val Leu His Pro Asp Ile Leu Val

165 170 175Asp Val Trp Glu Lys Ala Met Phe Val Glu Val Phe Gly Gly Leu Gly

180 185 190Ala Phe Val Glu Lys Gln Leu Gly Thr Leu Arg Thr His Phe Arg Ala

195 200 205Ser Leu Glu Ala Leu Met Glu Glu Val Ala Glu Val Ala Arg Ala Ala

210 215 220Gly Val Ala Leu Pro Ser Asp Ala Val Glu Arg Thr Met Asn Phe Ala225 230 235 240Asp Arg Met Pro Glu Asn Ser Thr Ser Ser Met Gln Arg Asp Leu Ala

245 250 255Ala Gly Val Ala Ser Glu Leu Glu Ala Gln Thr Gly Ala Ile Val Arg

260 265 270Ala Ala His Lys Val Gly Val Lys Thr Pro Leu His Asp Leu Ile Tyr

275 280 285Ala Gly Leu Lys Leu Lys Glu Glu Glu Asn Ser Leu

290295300<210>631<211>408<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (385)<223>RXC02238<400>631ggcgcttagc caaaacatag agcggtaggg tatgcttatc cgattgagca acctttcccg 60ctcttaacac tactgtccat atacttttga aaaggtgtca gtg acc aac gtg agc 115

Val Thr Asn Val Ser

1 5aac gag acc aac gcc acc aag gcc gtc ttc gat ccg cca gtg ggc att 163Asn Glu Thr Asn Ala Thr Lys Ala Val Phe Asp Pro Pro Val Gly Ile

10 15 20acc gct cct ccg atc gat gaa ctg ctg gat aag gtc act tcc aag tac 211Thr Ala Pro Pro Ile Asp Glu Leu Leu Asp Lys Val Thr Ser Lys Tyr

25 30 35gcc ctc gtg atc ttc gca gcc aag cgt gcg cgc cag atc aac agc ttc 259Ala Leu Val Ile Phe Ala Ala Lys Arg Ala Arg Gln Ile Asn Ser Phe

40 45 50tac cat cag gca gat gag gga gta ttc gag ttc atc gga cca ttg gtt 307Tyr His Gln Ala Asp Glu Gly Val Phe Glu Phe Ile Gly Pro Leu Val

55 60 65act ccg cag cca ggc gaa aag cca ctt tct att gct ctg cgt gag atc 355Thr Pro Gln Pro Gly Glu Lys Pro Leu Ser Ile Ala Leu Arg Glu Ile 70 75 80 85aat gca ggt ctg ttg gac cac gag gaa ggt taaaagacct tataacttca 405Asn Ala Gly Leu Leu Asp His Glu Glu Gly

9095 cac 408<210>632<211>95<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>632Val Thr Asn Val Ser Asn Glu Thr Asn Ala Thr Lys Ala Val Phe Asp 151015 Pro Pro Val Gly Ile Thr Ala Pro Pro Ile Asp Glu Leu Leu Asp Lys

20 25 30Val Thr Ser Lys Tyr Ala Leu Val Ile Phe Ala Ala Lys Arg Ala Arg

35 40 45Gln Ile Asn Ser Phe Tyr His Gln Ala Asp Glu Gly Val Phe Glu Phe

50 55 60Ile Gly Pro Leu Val Thr Pro Gln Pro Gly Glu Lys Pro Leu Ser Ile 65 70 75 80Ala Leu Arg Glu Ile Asn Ala Gly Leu Leu Asp His Glu Glu Gly

859095<210>633<211>606<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (583)<223>RXN03058<400>633acgagcttcc gctctgcaca agccgctaga agccccgcat agccctaatg tagagctcat 60gcccatttgg aatcacaaca ccgcatatcg gccatggctg gtg tca aag ctc aaa 115

Val Ser Lys Leu Lys

1 5ggc tca aga tcg ctt ctc gac gtc ggc tcc ggc gat cac tcc ttc gcc 163Gly Ser Arg Ser Leu Leu Asp Val Gly Ser Gly Asp His Ser Phe Ala

10 15 20gac ctg gcc ggc cgc cag gtc gcg cat gtc gat gtc gtg gat cct ctt 211Asp Leu Ala Gly Arg Gln Val Ala His Val Asp Val Val Asp Pro Leu

25 30 35att aat aca acc ttt gaa gaa ttc cag ccg acc caa agc tac gat gcc 259Ile Asn Thr Thr Phe Glu Glu Phe Gln Pro Thr Gln Ser Tyr Asp Ala

40 45 50atc acg ttc atc gcg tcc ctc cat cac atg aac gcg gaa gaa gga ctt 307Ile Thr Phe Ile Ala Ser Leu His His Met Asn Ala Glu Glu Gly Leu

55 60 65aac aaa gca gtc cga atc ctc aat cct ggc ggc aag ctc ctc atc gta 355Asn Lys Ala Val Arg Ile Leu Asn Pro Gly Gly Lys Leu Leu Ile Val 70 75 80 85ggc ctc gcc aaa aac aaa acc gcc tcc gac tgg atc atc tcc gga cta 403Gly Leu Ala Lys Asn Lys Thr Ala Ser Asp Trp Ile Ile Ser Gly Leu

90 95 100caa gct ttt ctc tcc cga cca atc agc ctc atc aat agg gaa caa caa 451Gln Ala Phe Leu Ser Arg Pro Ile Ser Leu Ile Asn Arg Glu Gln Gln

105 110 115atc tac ccc ttc cct acc aaa gaa ccc tca gag agt ctc cac gaa ata 499Ile Tyr Pro Phe Pro Thr Lys Glu Pro Ser Glu Ser Leu His Glu Ile

120 125 130cga caa ctc acc aag cag ctc ctc cct cac cgc cgt att cgc cgt gga 547Arg Gln Leu Thr Lys Gln Leu Leu Pro His Arg Arg Ile Arg Arg Gly

135140145 atc cac ttc cga tac ctc ctc gag tgg aca aag cct taaacagccc 593Ile His Phe Arg Tyr Leu Leu Glu Trp Thr Lys Pro 150155160 tatataaacacaa 606<210>634<211>161<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>634Val Ser Lys Leu Lys Gly Ser Arg Ser Leu Leu Asp Val Gly Ser Gly 151015 Asp His Ser Phe Ala Asp Leu Ala Gly Arg Gln Val Ala His Val Asp

20 25 30Val Val Asp Pro Leu Ile Asn Thr Thr Phe Glu Glu Phe Gln Pro Thr

35 40 45Gln Ser Tyr Asp Ala Ile Thr Phe Ile Ala Ser Leu His His Met Asn

50 55 60Ala Glu Glu Gly Leu Asn Lys Ala Val Arg Ile Leu Asn Pro Gly Gly 65 7075 80Lys Leu Leu Ile Val Gly Leu Ala Lys Asn Lys Thr Ala Ser Asp Trp

85 90 95Ile Ile Ser Gly Leu Gln Ala Phe Leu Ser Arg Pro Ile Ser Leu Ile

100 105 110Asn Arg Glu Gln Gln Ile Tyr Pro Phe Pro Thr Lys Glu Pro Ser Glu

115 120 125Ser Leu His Glu Ile Arg Gln Leu Thr Lys Gln Leu Leu Pro His Arg

130135140 Arg Ile Arg Arg Gly Ile His Phe Arg Tyr Leu Leu Glu Trp Thr Lys 145150155160 Pro<210>635<211>606<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (583)<223>FRXA02903<400>635acgagcttcc gctctgcaca agccgctaga agccccgcat agccctaatg tagagctcat 60gcccatttgg aatcacaaca ccgcatatcg gccatggctg gtg tca aag ctc aaa 115

Val Ser Lys Leu Lys

1 5ggc tca aga tcg ctt ctc gac gtc ggc tcc ggc gat cac tcc ttc gcc 163Gly Ser Arg Ser Leu Leu Asp Val Gly Ser Gly Asp His Ser Phe Ala

10 15 20gac ctg gcc ggc cgc cag gtc gcg cat gtc gat gtc gtg gat cct ctt 211Asp Leu Ala Gly Arg Gln Val Ala His Val Asp Val Val Asp Pro Leu

25 30 35att aat aca acc ttt gaa gaa ttc cag ccg acc caa agc tac gat gcc 259Ile Asn Thr Thr Phe Glu Glu Phe Gln Pro Thr Gln Ser Tyr Asp Ala

40 45 50atc acg ttc atc gcg tcc ctc cat cac atg aac gcg gaa gaa gga ctt 307Ile Thr Phe Ile Ala Ser Leu His His Met Asn Ala Glu Glu Gly Leu

55 60 65aac aaa gca gtc cga atc ctc aat cct ggc ggc aag ctc ctc atc gta 355Asn Lys Ala Val Arg Ile Leu Asn Pro Gly Gly Lys Leu Leu Ile Val 70 75 80 85ggc ctc gcc aaa aac aaa acc gcc tcc gac tgg atc atc tcc gga cta 403Gly Leu Ala Lys Asn Lys Thr Ala Ser Asp Trp Ile Ile Ser Gly Leu

90 95 100caa gct ttt ctc tcc cga cca atc agc ctc atc aat agg gaa caa caa 451Gln Ala Phe Leu Ser Arg Pro Ile Ser Leu Ile Asn Arg Glu Gln Gln

105 110 115atc tac ccc ttc cct acc aaa gaa ccc tca gag agt ctc cac gaa ata 499Ile Tyr Pro Phe Pro Thr Lys Glu Pro Ser Glu Ser Leu His Glu Ile

120 125 130cga caa ctc acc aag cag ctc ctc cct cac cgc cgt att cgc cgt gga 547Arg Gln Leu Thr Lys Gln Leu Leu Pro His Arg Arg Ile Arg Arg Gly

135140145 atc cac ttc cga tac ctc ctc gag tgg aca aag cct taaacagccc 593Ile His Phe Arg Tyr Leu Leu Glu Trp Thr Lys Pro 150155160 tatataaaccaa 606<210>636<211>161<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>636Val Ser Lys Leu Lys Gly Ser Arg Ser Leu Leu Asp Val Gly Ser Gly 151015 Asp His Ser Phe Ala Asp Leu Ala Gly Arg Gln Val Ala His Val Asp

20 25 30Val Val Asp Pro Leu Ile Asn Thr Thr Phe Glu Glu Phe Gln Pro Thr

35 40 45Gln Ser Tyr Asp Ala Ile Thr Phe Ile Ala Ser Leu His His Met Asn

50 55 60Ala Glu Glu Gly Leu Asn Lys Ala Val Arg Ile Leu Asn Pro Gly Gly 65 70 75 80LysLeu Leu Ile Val Gly Leu Ala Lys Asn Lys Thr Ala Ser Asp Trp

85 90 95Ile Ile Ser Gly Leu Gln Ala Phe Leu Ser Arg Pro Ile Ser Leu Ile

100 105 110Asn Arg Glu Gln Gln Ile Tyr Pro Phe Pro Thr Lys Glu Pro Ser Glu

115 120 125Ser Leu His Glu Ile Arg Gln Leu Thr Lys Gln Leu Leu Pro His Arg

130135140 Arg Ile Arg Arg Gly Ile His Phe Arg Tyr Leu Leu Glu Trp Thr Lys 145150155160 Pro<210>637<211>783<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (760)<223>RXA00166<400>637ggcgtttagc gatcttcaac atcgagcaac cagcgccagc gcttttaccc aaggcagcac 60gacttatcac gatgtccgac ctggatatcc ggctgaggcc gtg gag tta gcc cgt 115

Val Glu Leu Ala Arg

1 5ggg ttt ggc cga gtc ctg gat gtc ggt gca ggt acc gga aaa cta acc 163Gly Phe Gly Arg Val Leu Asp Val Gly Ala Gly Thr Gly Lys Leu Thr

10 15 20agt gag cta aca gct gat cag gtc cta gcc ctt gat cca agc atg gac 211Ser Glu Leu Thr Ala Asp Gln Val Leu Ala Leu Asp Pro Ser Met Asp

25 30 35atg ttg cgg gtg ttt cgc tcc gcg ctt ccg gcg gtt ccc tgc tgg caa 259Met Leu Arg Val Phe Arg Ser Ala Leu Pro Ala Val Pro Cys Trp Gln

40 45 50gcg aca gca gaa cac aca gga ata cgt gac aac gcg gtt gat ctg att 307Ala Thr Ala Glu His Thr Gly Ile Arg Asp Asn Ala Val Asp Leu Ile

5560 65acg tgc gca caa acg tgg cat tgg gtt gac gtg acg gct gcc tca gcg 355Thr Cys Ala Gln Thr Trp His Trp Val Asp Val Thr Ala Ala Ser Ala 70 75 80 85gaa ttt gat cgg gtg att gca cct gag ggt gca gtc ctg ctc gtg tgg 403Glu Phe Asp Arg Val Ile Ala Pro Glu Gly Ala Val Leu Leu Val Trp

90 95 100aat aac ctg gac acc tcc atc gcg tgg gta cac cga ctc agt cgc att 451Asn Asn Leu Asp Thr Ser Ile Ala Trp Val His Arg Leu Ser Arg Ile

105 110 115atg cat gcc ggc gat gta ctc aag ccg gga ttc acc cca gaa acc gca 499Met His Ala Gly Asp Val Leu Lys Pro Gly Phe Thr Pro Glu Thr Ala

120 125 130gct ccc tgg ata att gat cga gaa att cgc acc acg tgg aat cag cac 547Ala Pro Trp Ile Ile Asp Arg Glu Ile Arg Thr Thr Trp Asn Gln His

135 140 145ctc acc cct gaa gaa atc atc cag ctc gct cac acg agg tcc tac tgg 595Leu Thr Pro Glu Glu Ile Ile Gln Leu Ala His Thr Arg Ser Tyr Trp150 155 160 165tta aac gcg tca gag aaa atc aaa gag cgt gtt gat cag aac ctt cag 643Leu Asn Ala Ser Glu Lys Ile Lys Glu Arg Val Asp Gln Asn Leu Gln

170 175 180tgg tat ctc tac gag cat ttg ggt ttc agt ccc gac aat cca gtg gaa 691Trp Tyr Leu Tyr Glu His Leu Gly Phe Ser Pro Asp Asn Pro Val Glu

185 190 195ctt ccc tat cgc tgt gat gca ttt tta ctt tca cgt tcc ggt acc ctg 739Leu Pro Tyr Arg Cys Asp Ala Phe Leu Leu Ser Arg Ser Gly Thr Leu

200 205 210gca ggc aga tct tcc aat ctt taggagccct cgccatgtac ctg783Ala Gly Arg Ser Ser Asn Leu

215220<210>638<211>220<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>638Val Glu Leu Ala Arg Gly Phe Gly Arg Val Leu Asp Val Gly Ala Gly 151015 Thr Gly Lys Leu Thr Ser Glu Leu Thr Ala Asp Gln Val Leu Ala Leu

20 25 30Asp Pro Ser Met Asp Met Leu Arg Val Phe Arg Ser Ala Leu Pro Ala

35 40 45Val Pro Cys Trp Gln Ala Thr Ala Glu His Thr Gly Ile Arg Asp Asn

50 55 60Ala Val Asp Leu Ile Thr Cys Ala Gln Thr Trp His Trp Val Asp Val 65 70 75 80Thr Ala Ala Ser Ala Glu Phe Asp Arg Val Ile Ala Pro Glu Gly Ala

85 90 95Val Leu Leu Val Trp Asn Asn Leu Asp Thr Ser Ile Ala Trp Val His

100 105 110Arg Leu Ser Arg Ile Met His Ala Gly Asp Val Leu Lys Pro Gly Phe

115 120 125Thr Pro Glu Thr Ala Ala Pro Trp Ile Ile Asp Arg Glu Ile Arg Thr

130 135 140Thr Trp Asn Gln His Leu Thr Pro Glu Glu Ile Ile Gln Leu Ala His145 150 155 160Thr Arg Ser Tyr Trp Leu Asn Ala Ser Glu Lys Ile Lys Glu Arg Val

165 170 175Asp Gln Asn Leu Gln Trp Tyr Leu Tyr Glu His Leu Gly Phe Ser Pro

180 185 190Asp Asn Pro Val Glu Leu Pro Tyr Arg Cys Asp Ala Phe Leu Leu Ser

195 200205Arg Ser Gly Thr Leu Ala Gly Arg Ser Ser Asn Leu

210215220<210>639<211>1392<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<1369><223>RXA00633<400>639aaagctgcgg taattaaaaa cacttagcgc caaaaattga acactgttca attaacctat 60tacactgcag atatacatcc aaaccaagtg acggaggaaa atg gaa aac ccc agc 115

Met Glu Asn Pro Ser

1 5ttg cgc gag ctt gat cac cga aac atc tgg cac ccg tat gcc gcg ccg 163Leu Arg Glu Leu Asp His Arg Asn Ile Trp His Pro Tyr Ala Ala Pro

10 15 20ggc gtg cgc aat aga ctc gtc acc aaa acc gat gga gtg ttt ttg acg 211Gly Val Arg Asn Arg Leu Val Thr Lys Thr Asp Gly Val Phe Leu Thr

25 30 35ctg gaa gat ggc agc acc gtg att gac gcg atg agc tcc tgg tgg tcg 259Leu Glu Asp Gly Ser Thr Val Ile Asp Ala Met Ser Ser Trp Trp Ser

40 45 50gca att cat gga cac gga cac ccc cga ctg aaa gct gcc gcc caa aaa 307Ala Ile His Gly His Gly His Pro Arg Leu Lys Ala Ala Ala Gln Lys

55 60 65caa atc gac acc atg agt cac gtc atg ttt ggc gga cta acc cac gag 355Gln Ile Asp Thr Met Ser His Val Met Phe Gly Gly Leu Thr His Glu 70 75 80 85ccc gcc att aag ctc acc cac aaa ctc ctc aat ctc act gga aat tcc 403Pro Ala Ile Lys Leu Thr His Lys Leu Leu Asn Leu Thr Gly Asn Ser

90 95 100ttt gac cac gtc ttt tat tcc gat tcg ggc tcg gtc tca gtg gag gtc 451Phe Asp His Val Phe Tyr Ser Asp Ser Gly Ser Val Ser Val Glu Val

105 110 115gcc atc aaa atg gca ctg cag gcc tcc aaa gga caa ggc cac ccg gaa 499Ala Ile Lys Met Ala Leu Gln Ala Ser Lys Gly Gln Gly His Pro Glu

120 125 130cgg aca aaa ctc ctc acc tgg cgg tcc ggc tac cac gga gac aca ttc 547Arg Thr Lys Leu Leu Thr Trp Arg Ser Gly Tyr His Gly Asp Thr Phe

135 140 145acc gcg atg agc gtg tgc gac cca gaa aat ggc atg cat agc ctc tgg 595Thr Ala Met Ser Val Cys Asp Pro Glu Asn Gly Met His Ser Leu Trp150 155 160 165aaa ggc aca ctc ccc gag cag att ttc gcc ccc gcc cca cca gtt cgg 643Lys Gly Thr Leu Pro Glu Gln Ile Phe Ala Pro Ala Pro Pro Val Arg

170 175 180ggg tca tcg ccg cag gcg att tcc gag tac ctg cgc agc atg gaa ttg 691Gly Ser Ser Pro Gln Ala Ile Ser Glu Tyr Leu Arg Ser Met Glu Leu

185 190 195ctt atc gac gag gcg gtc tcc gca atc atc atc gaa ccg atc gtc caa 739Leu Ile Asp Glu Ala Val Ser Ala Ile Ile Ile Glu Pro Ile Val Gln

200 205 210ggc gct gga ggc atg cgc ttt cac gat gtc gca ctc att gaa gga gtc 787Gly Ala Gly Gly Met Arg Phe His Asp Val Ala Leu Ile Glu Gly Val

215 220 225gcc aca ctg tgc aag aag cac gat cgt ttc ttg atc gtc gat gaa att 835Ala Thr Leu Cys Lys Lys His Asp Arg Phe Leu Ile Val Asp Glu Ile230 235 240 245gcc act ggt ttc ggc cgc acc ggt gaa cta ttt gcc acg tta agc aat 883Ala Thr Gly Phe Gly Arg Thr Gly Glu Leu Phe Ala Thr Leu Ser Asn

250255 260ggc cta caa cca gac atc atg tgt gtg ggc aag gcc ctc acc ggt gga 931Gly Leu Gln Pro Asp Ile Met Cys Val Gly Lys Ala Leu Thr Gly Gly

265 270 275ttc atg tcc ttc gcc gct act tta tgc acg gac aag gtg gct caa tta 979Phe Met Ser Phe Ala Ala Thr Leu Cys Thr Asp Lys Val Ala Gln Leu

280 285 290atc agc acc cca aat ggc gga ggt gcg ctg atg cac ggc ccc act ttt 1027Ile Ser Thr Pro Asn Gly Gly Gly Ala Leu Met His Gly Pro Thr Phe

295 300 305atg gct aat cct ctg gcc tgt gcg gtt tcg cat gct tca tta gaa atc 1075Met Ala Asn Pro Leu Ala Cys Ala Val Ser His Ala Ser Leu Glu Ile310 315 320 325att gag acc ggc atg tgg cag aaa cag gta aaa aga atc gaa gcc gaa 1123Ile Glu Thr Gly Met Trp Gln Lys Gln Val Lys Arg Ile Glu Ala Glu

330 335 340ctt atc gca ggc ctt tcc cca ctt caa cac ctt cca ggg gtt gcc gat 1171Leu Ile Ala Gly Leu Ser Pro Leu Gln His Leu Pro Gly Val Ala Asp

345 350 355gtc cgg gtt ctc ggc gcg att ggt gtc atc gaa atg gaa caa aat gtc 1219Val Arg Val Leu Gly Ala Ile Gly Val Ile Glu Met Glu Gln Asn Val

360 365 370aat gtc gaa gaa gct act cag gct gca tta gat cac ggt gtg tgg atc 1267Asn Val Glu Glu Ala Thr Gln Ala Ala Leu Asp His Gly Val Trp Ile

375 380 385cgc ccc ttt gga cgc ttg ctc tat gtc atg cct cca tat atc acc acg 1315Arg Pro Phe Gly Arg Leu Leu Tyr Val Met Pro Pro Tyr Ile Thr Thr390 395 400 405tca gag cag tgc gca cag atc tgc act gcg ctt cat gct gca gtt aaa 1363Ser Glu Gln Cys Ala Gln Ile Cys Thr Ala Leu His Ala Ala Val Lys

410415420 ggg aaa taaaccatgc catttttatt tgt 1392Gly Lys<210>640<211>423<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>640Met Glu Asn Pro Ser Leu Arg Glu Leu Asp His Arg Asn Ile Trp His 151015 Pro Tyr Ala Ala Pro Gly Val Arg Asn Arg Leu Val Thr Lys Thr Asp

20 25 30Gly Val Phe Leu Thr Leu Glu Asp Gly Ser Thr Val Ile Asp Ala Met

35 40 45Ser Ser Trp Trp Ser Ala Ile His Gly His Gly His Pro Arg Leu Lys

50 55 60Ala Ala Ala Gln Lys Gln Ile Asp Thr Met Ser His Val Met Phe Gly 65 70 75 80Gly Leu Thr His Glu Pro Ala Ile Lys Leu Thr His Lys Leu Leu Asn

85 90 95Leu Thr Gly Asn Ser Phe Asp His Val Phe Tyr Ser Asp Ser Gly Ser

100 105 110Val Ser Val Glu Val Ala Ile Lys Met Ala Leu Gln Ala Ser Lys Gly

115 120 125Gln Gly His Pro Glu Arg Thr Lys Leu Leu Thr Trp Arg Ser Gly Tyr

130 135 140His Gly Asp Thr Phe Thr Ala Met Ser Val Cys Asp Pro Glu Asn Gly145 150 155 160Met His Ser Leu Trp Lys Gly Thr Leu Pro Glu Gln Ile Phe Ala Pro

165 170 175Ala Pro Pro Val Arg Gly Ser Ser Pro Gln Ala Ile Ser Glu Tyr Leu

180 185 190Arg Ser Met Glu Leu Leu Ile Asp Glu Ala Val SerAla Ile Ile Ile

195 200 205Glu Pro Ile Val Gln Gly Ala Gly Gly Met Arg Phe His Asp Val Ala

210 215 220Leu Ile Glu Gly Val Ala Thr Leu Cys Lys Lys His Asp Arg Phe Leu225 230 235 240Ile Val Asp Glu Ile Ala Thr Gly Phe Gly Arg Thr Gly Glu Leu Phe

245 250 255Ala Thr Leu Ser Asn Gly Leu Gln Pro Asp Ile Met Cys Val Gly Lys

260 265 270Ala Leu Thr Gly Gly Phe Met Ser Phe Ala Ala Thr Leu Cys Thr Asp

275 280 285Lys Val Ala Gln Leu Ile Ser Thr Pro Asn Gly Gly Gly Ala Leu Met

290 295 300His Gly Pro Thr Phe Met Ala Asn Pro Leu Ala Cys Ala Val Ser His305 310 315 320Ala Ser Leu Glu Ile Ile Glu Thr Gly Met Trp Gln Lys Gln Val Lys

325 330 335Arg Ile Glu Ala Glu Leu Ile Ala Gly Leu Ser Pro Leu Gln His Leu

340 345 350Pro Gly Val Ala Asp Val Arg Val Leu Gly Ala Ile Gly Val Ile Glu

355 360 365Met Glu Gln Asn Val Asn Val Glu Glu Ala Thr Gln Ala Ala Leu Asp

370 375 380His Gly Val Trp Ile Arg Pro Phe Gly Arg Leu Leu Tyr Val Met Pro385 390 395 400Pro Tyr Ile Thr Thr Ser Glu Gln Cys Ala Gln Ile Cys Thr Ala Leu

405 410 415His Ala Ala Val Lys Gly Lys

420<210>641<211>795<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (772)<223>RXA00632<400>641tggacgcttg ctctatgtca tgcctccata tatcaccacg tcagagcagt gcgcacagat 60ctgcactgcg cttcatgctg cagttaaagg gaaataaacc atg cca ttt tta ttt 115

Met Pro Phe Leu Phe

1 5gtc agc ggt acc gga act ggg gtt ggg aaa acc ttc tcc aca gcc gtt 163Val Ser Gly Thr Gly Thr Gly Val Gly Lys Thr Phe Ser Thr Ala Val

10 15 20ttg gtt cga tac tta gcc gat caa gga cac gat gtt ctg ccc gta aag 211Leu Val Arg Tyr Leu Ala Asp Gln Gly His Asp Val Leu Pro Val Lys

25 30 35cta gtc caa acc ggt gaa ctt cca ggc gag gga gac atc ttt aac att 259Leu Val Gln Thr Gly Glu Leu Pro Gly Glu Gly Asp Ile Phe Asn Ile

40 45 50gaa cgc ttg act gga att gct gga gag gaa ttt gct cgt ttc aaa gac 307Glu Arg Leu Thr Gly Ile Ala Gly Glu Glu Phe Ala Arg Phe Lys Asp

55 60 65cct ctt gcg cca aat ctg gca gcc cga cga gag ggg gtc gag cca ata 355Pro Leu Ala Pro Asn Leu Ala Ala Arg Arg Glu Gly Val Glu Pro Ile 70 75 80 85cag ttt gat cag att atc tcg tgg ctt cgt ggt ttt gac gac cca gat 403Gln Phe Asp Gln Ile Ile Ser Trp Leu Arg Gly Phe Asp Asp Pro Asp

90 95 100cgc atc att gtg gtg gag ggc gct ggt ggc ctg ctg gtc aga tta ggg 451Arg Ile Ile Val Val Glu Gly Ala Gly Gly Leu Leu Val Arg Leu Gly

105 110 115gaa gat ttc acc ctg gca gat gtt gcc tcc gct ttg aat gca ccc tta 499Glu Asp Phe Thr Leu Ala Asp Val Ala Ser Ala Leu Asn Ala Pro Leu

120 125 130gtg att gtg aca agc acc gga ttg gga agc ctc aac gct gct gaa tta 547Val Ile Val Thr Ser Thr Gly Leu Gly Ser Leu Asn Ala Ala Glu Leu

135 140 145agc gtt gag gca gca aac cgc cga gga ctc aca gtg ttg gga gtc ctc 595Ser Val Glu Ala Ala Asn Arg Arg Gly Leu Thr Val Leu Gly Val Leu150 155 160 165ggc ggt tcg atc cct caa aat cct gat cta gct acg atg ctt aat ctc 643Gly Gly Ser Ile Pro Gln Asn Pro Asp Leu Ala Thr Met Leu Asn Leu

170 175 180gaa gaa ttt gag aga gtc acc ggc gtg ccc ttt tgg gga gct ttg ccg 691Glu Glu Phe Glu Arg Val Thr Gly Val Pro Phe Trp Gly Ala Leu Pro

185 190 195gaa ggg ttg tca cgg gtg gag ggg ttc gtc gaa aag caa tct ttt ccg 739Glu Gly Leu Ser Arg Val Glu Gly Phe Val Glu Lys Gln Ser Phe Pro

200 205 210gcc ctt gat gcc ttt aag aaa ccg ccg gca agg tgatcgtgaa caccgtgcct 792Ala Leu Asp Ala Phe Lys Lys Pro Pro Ala Arg

215220 tcg 795<210>642<211>224<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>642Met Pro Phe Leu Phe Val Ser Gly Thr Gly Thr Gly Val Gly Lys Thr 151015 Phe Ser Thr Ala Val Leu Val Arg Tyr Leu Ala Asp Gln Gly His Asp

20 25 30Val Leu Pro Val Lys Leu Val Gln Thr Gly G1u Leu Pro Gly Glu Gly

35 40 45Asp Ile Phe Asn Ile Glu Arg Leu Thr Gly Ile Ala Gly Glu Glu Phe

50 55 60Ala Arg Phe Lys Asp Pro Leu Ala Pro Asn Leu Ala Ala Arg Arg Glu 65 70 75 80Gly Val Glu Pro Ile Gln Phe Asp Gln Ile Ile Ser Trp Leu Arg Gly

85 90 95Phe Asp Asp Pro Asp Arg Ile Ile Val Val Glu Gly Ala Gly Gly Leu

100 105 110Leu Val Arg Leu Gly Glu Asp Phe Thr Leu Ala Asp Val Ala Ser Ala

115 120 125Leu Asn Ala Pro Leu Val Ile Val Thr Ser Thr Gly Leu Gly Ser Leu

130 135 140Asn Ala Ala Glu Leu Ser Val Glu Ala Ala Asn Arg Arg Gly Leu Thr145 150 155 160Val Leu Gly Val Leu Gly Gly Ser Ile Pro Gln Asn Pro Asp Leu Ala

165 170 175Thr Met Leu Asn Leu Glu Glu Phe Glu Arg Val Thr Gly Val Pro Phe

180 185 190Trp Gly Ala Leu Pro Glu Gly Leu Ser Arg Val Glu Gly Phe Val Glu

195 200 205Lys Gln Ser Phe Pro Ala Leu Asp Ala Phe Lys Lys Pro Pro Ala Arg

210215220<210>643<211>1125<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1102)<223>RXA00295<400>643gtttaaggca cgtgtcattt tgcatgcgcg tgcccaattc ttcttaagtg tgctcaattt 60ttaagcgcgc agttattgac aaccagcctc taggagatcc atg acc atc ccc ggc 115

Met Thr Ile Pro Gly

1 5acc atc ctt gac acc gcc cgc acc caa gtt ctg gaa cag gga att ggc 163Thr Ile Leu Asp Thr Ala Arg Thr Gln Val Leu Glu Gln Gly Ile Gly

10 15 20ctt aat cag cag cag ttg atg gag gtt ctc acc ttg cct gaa gag caa 211Leu Asn Gln Gln Gln Leu Met Glu Val Leu Thr Leu Pro Glu Glu Gln

25 30 35atc cca gac ttg atg gaa tta gcc cac cag gtt cgg ttg aag tgg tgt 259Ile Pro Asp Leu Met Glu Leu Ala His Gln Val Arg Leu Lys Trp Cys

40 45 50ggg gaa gaa atc gag gtc gag ggc att att tcc ctc aaa act ggc ggt 307Gly Glu Glu Ile Glu Val Glu Gly Ile Ile Ser Leu Lys Thr Gly Gly

55 60 65tgc cct gaa gat tgt cat ttc tgc tca cag tct ggg ttg ttt gaa tcg 355Cys Pro Glu Asp Cys His Phe Cys Ser Gln Ser Gly Leu Phe Glu Ser 70 75 80 85ccg gtg cgt tcg gtg tgg ctg gat att ccg aat ctg gtt gaa gcc gct 403Pro Val Arg Ser Val Trp Leu Asp Ile Pro Asn Leu Val Glu Ala Ala

90 95 100aaa cag acc gca aaa act ggc gct acc gaa ttc tgt atc gtc gcc gca 451Lys Gln Thr Ala Lys Thr Gly Ala Thr Glu Phe Cys Ile Val Ala Ala

105 110 115gtc aag ggg cct gat gag agg ctc atg acc cag ctg gag gaa gca gtc 499Val Lys Gly Pro Asp Glu Arg Leu Met Thr Gln Leu Glu Glu Ala Val

120 125 130ctc gcg att cac tct gaa gtt gaa att gaa gtc gca gca tcg atc gga 547Leu Ala Ile His Ser Glu Val Glu Ile Glu Val Ala Ala Ser Ile Gly

135 140 145acg tta aat aag gaa cag gtg gat cgc ctc gct gct gcc ggc gtg cac 595Thr Leu Asn Lys Glu Gln Val Asp Arg Leu Ala Ala Ala Gly Val His150 155 160 165cgc tac aac cat aat ttg gaa act gcg cgt tcc tat ttc cct gaa gtt 643Arg Tyr Asn His Asn Leu Glu Thr Ala Arg Ser Tyr Phe Pro Glu Val

170 175 180gtc acc act cat aca tgg gaa gag cgc cgc gaa act ttg cgc ctg gtg 691Val Thr Thr His Thr Trp Glu Glu Arg Arg Glu Thr Leu Arg Leu Val

185 190 195gca gaa gct gga atg gaa gtc tgt tcc ggc gga atc tta gga atg ggc 739Ala Glu Ala Gly Met Glu Val Cys Ser Gly Gly Ile Leu Gly Met Gly

200 205 210gaa act tta gag cag cgc gcc gag ttt gcc gtg cag ctg gcg gag ctt 787Glu Thr Leu Glu Gln Arg Ala Glu Phe Ala Val Gln Leu Ala Glu Leu

215 220 225gat ccg cac gaa gtc ccc atg aac ttc ctt gat cct cgc ccg ggc acc 835Asp Pro His Glu Val Pro Met Asn Phe Leu Asp Pro Arg Pro Gly Thr230 235 240 245cca ttt gcc gat agg gaa ttg atg gac agc cgt gac gct ctg cgc tct 883Pro Phe Ala Asp Arg Glu Leu Met Asp Ser Arg Asp Ala Leu Arg Ser

250 255 260att ggt gcg ttc cgc ctt gcg atg cct cac acc atg ctt cgt ttt gct 931Ile Gly Ala Phe Arg Leu Ala Met Pro His Thr Met Leu Arg Phe Ala

265 270 275ggc ggt cgc gag ctg act ttg ggc gac aag ggt tcc gag caa gcc ctc 979Gly Gly Arg Glu Leu Thr Leu Gly Asp Lys Gly Ser Glu Gln Ala Leu

280 285 290ctg gga ggc atc aat gcg atg atc gtc gga aac tac ctg act acg ctc 1027Leu Gly Gly Ile Asn Ala Met Ile Val Gly Asn Tyr Leu Thr Thr Leu

295 300 305ggc cgc cca atg gaa gat gac ctc gac atg atg gat cgt ctc cag ctg 1075Gly Arg Pro Met Glu Asp Asp Leu Asp Met Met Asp Arg Leu Gln Leu310 315 320 325ccc atc aaa gtc ctt aat aag gtc atc taagaagcac gcgcatgaac 1122Pro Ile Lys Val Leu Asn Lys Val Ile

330gac 1125<210>644<211>334<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>644Met Thr Ile Pro Gly Thr Ile Leu Asp Thr Ala Arg Thr Gln Val Leu 151015 Glu Gln Gly Ile Gly Leu Asn Gln Gln Gln Leu Met Glu Val Leu Thr

20 25 30Leu Pro Glu Glu Gln Ile Pro Asp Leu Met Glu Leu Ala His Gln Val

35 40 45Arg Leu Lys Trp Cys Gly Glu Glu Ile Glu Val Glu Gly Ile Ile Ser

50 55 60Leu Lys Thr Gly Gly Cys Pro Glu Asp Cys His Phe Cys Ser Gln Ser 65 70 75 80Gly Leu Phe Glu Ser Pro Val Arg Ser Val Trp Leu Asp Ile Pro Asn

85 90 95Leu Val Glu Ala Ala Lys Gln Thr Ala Lys Thr Gly Ala Thr Glu Phe

100 105 110Cys Ile Val Ala Ala Val Lys Gly Pro Asp Glu Arg Leu Met Thr Gln

115 120 125Leu Glu Glu Ala Val Leu Ala Ile His Ser Glu Val Glu Ile Glu Val

130 135 140Ala Ala Ser Ile Gly Thr Leu Asn Lys Glu Gln Val Asp Arg Leu Ala145 150 155 160Ala Ala Gly Val His Arg Tyr Asn His Asn Leu Glu Thr Ala Arg Ser

165 170 175Tyr Phe Pro Glu Val Val Thr Thr His Thr Trp Glu Glu Arg Arg Glu

180 185 190Thr Leu Arg Leu Val Ala Glu Ala Gly Met Glu Val Cys Ser Gly Gly

195 200 205Ile Leu Gly Met Gly Glu Thr Leu Glu Gln Arg Ala Glu Phe Ala Val

210 215 220Gln Leu Ala Glu Leu Asp Pro His Glu Val Pro Met Asn Phe Leu Asp225 230 235 240Pro Arg Pro Gly Thr Pro Phe Ala Asp Arg Glu Leu Met Asp Ser Arg

245 250 255Asp Ala Leu Arg Ser Ile Gly Ala Phe Arg Leu Ala Met Pro His Thr

260 265 270Met Leu Arg Phe Ala Gly Gly Arg Glu Leu Thr Leu Gly Asp Lys Gly

275 280 285Ser Glu Gln Ala Leu Leu Gly Gly Ile Asn Ala Met Ile Val Gly Asn

290 295 300Tyr Leu Thr Thr Leu Gly Arg Pro Met Glu Asp Asp Leu Asp Met Met305 310 315 320Asp Arg Leu Gln Leu Pro Ile Lys Val Leu Asn Lys Val Ile

325330<210>645<211>1212<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1189)<223>RXA00223<400>645gcgacctctt tgacatcgcc cctgcgctca tcgaagagat caacaagcgc aagtaggagt 60tttgaacact ttttatctgg accatgcagc caccacacca atg cgt gag gtg gcc 115

Met Arg Glu Val Ala

1 5gca gct gcg tgg atg gaa aac gcg cag gca ttg aat ccc gcg agt cag 163Ala Ala Ala Trp Met Glu Asn Ala Gln Ala Leu Asn Pro Ala Ser Gln

10 15 20tac ggt tcg ggg cgt aag gcg cgc agc gtt gcg gat tcg gct cgt gaa 211Tyr Gly Ser Gly Arg Lys Ala Arg Ser Val Ala Asp Ser Ala Arg Glu

25 30 35gaa att gct tct ttg ctg ggc tgt gaa cct atc gag gtt gtg ttt acc 259Glu Ile Ala Ser Leu Leu Gly Cys Glu Pro Ile Glu Val Val Phe Thr

40 45 50gcg tcc ggc acg gag gca gat aac ctc gct gtg cag ggg tta ttc cac 307Ala Ser Gly Thr Glu Ala Asp Asn Leu Ala Val Gln Gly Leu Phe His

55 60 65gca tcg cct ctc aat cgg att att tct acg ccg atc gag cac ccc ggg 355Ala Ser Pro Leu Asn Arg Ile Ile Ser Thr Pro Ile Glu His Pro Gly 70 75 80 85att ctg gaa acc gtc aag gct cta gaa ctt ggc ggg gca gag gcg gag 403Ile Leu Glu Thr Val Lys Ala Leu Glu Leu Gly Gly Ala Glu Ala Glu

90 95 100ctc atg ccg atc ggt cca gat gga cga gtg tct tcc ttc gaa gcg ctg 451Leu Met Pro Ile Gly Pro Asp Gly Arg Val Ser Ser Phe Glu Ala Leu

105 110 115gac aag cct gcc gcg gtt gcc act atg atg tgg gcg aac aat gag acc 499Asp Lys Pro Ala Ala Val Ala Thr Met Met Trp Ala Asn Asn Glu Thr

120 125 130ggc gcg att cag ccg gtt tct gag ttc atc gcc gcc gcg cag gcg tcc 547Gly Ala Ile Gln Pro Val Ser Glu Phe Ile Ala Ala Ala Gln Ala Ser

135 140 145ggc acg cca aca cac atc gat gcg gtt cag gtc gtt ggc cat ctg ccg 595Gly Thr Pro Thr HisIle Asp Ala Val Gln Val Val Gly His Leu Pro150 155 160 165gtc aat ttt gat gag ctc ggc gcc acc act ttg gct gcc tcc gcg cac 643Val Asn Phe Asp Glu Leu Gly Ala Thr Thr Leu Ala Ala Ser Ala His

170 175 180aaa ttc ggt gga cca cgt ggc gtc ggc ctg ctg ttg gtg agg cgc tca 691Lys Phe Gly Gly Pro Arg Gly Val Gly Leu Leu Leu Val Arg Arg Ser

185 190 195cca gca cct tca gcc gta ttg cac gga ggt ggt cag gag cgc ggc atc 739Pro Ala Pro Ser Ala Val Leu His Gly Gly Gly Gln Glu Arg Gly Ile

200 205 210cgt cca ggc acc ctt gat gtc gcc ggc gca gct gcc acc gca gcc gca 787Arg Pro Gly Thr Leu Asp Val Ala Gly Ala Ala Ala Thr Ala Ala Ala

215 220 225tta cgc gaa gca gtg gcc gag ctt gac ggc gaa gcc acc cgc ctg cgc 835Leu Arg Glu Ala Val Ala Glu Leu Asp Gly Glu Ala Thr Arg Leu Arg230 235 240 245gga ctt aaa aag atg ctt ctc gac gcc atc ctc cac acc atc ccc aac 883Gly Leu Lys Lys Met Leu Leu Asp Ala Ile Leu His Thr Ile Pro Asn

250 255 260gta ctg gtc cac acc acc gaa cca tcc ctg cca gga cac ctg cat ctc 931Val Leu Val His Thr Thr Glu Pro Ser Leu Pro Gly His Leu His Leu

265 270 275tcc ttc cca gga gca gaa ggc gat agt ttg atc atg ctg ctc gac tcc 979Ser Phe Pro Gly Ala Glu Gly Asp Ser Leu Ile Met Leu Leu Asp Ser

280 285 290ttg cgg atc gaa gcc tcc aca ggt tcg gcc tgc tcc aac ggt gta aac 1027Leu Arg Ile Glu Ala Ser Thr Gly Ser Ala Cys Ser Asn Gly Val Asn

295300 305cgt gcc agc cac gtc ctt ttg gcc atg gga att tcc gaa acc gac gcc 1075Arg Ala Ser His Val Leu Leu Ala Met Gly Ile Ser Glu Thr Asp Ala310 315 320 325cgt ggt gcc atc cga ttc acc ctc gga aga acc acc act gaa gaa tcc 1123Arg Gly Ala Ile Arg Phe Thr Leu Gly Arg Thr Thr Thr Glu Glu Ser

330 335 340atc aag gca gtg atc gcc gtg atc gaa gac gta gtg acc agg gct cgt 1171Ile Lys Ala Val Ile Ala Val Ile Glu Asp Val Val Thr Arg Ala Arg

345 350 355act gcg gga atg get ttt tagcgaccgt aaatcgcata gtg 1212Thr Ala Gly Met Ala Phe

360<210>646<211>363<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>646Met Arg Glu Val Ala Ala Ala Ala Trp Met Glu Asn Ala Gln Ala Leu 151015 Asn Pro Ala Ser Gln Tyr Gly Ser Gly Arg Lys Ala Arg Ser Val Ala

20 25 30Asp Ser Ala Arg Glu Glu Ile Ala Ser Leu Leu Gly Cys Glu Pro Ile

35 40 45Glu Val Val Phe Thr Ala Ser Gly Thr Glu Ala Asp Asn Leu Ala Val

50 55 60Gln Gly Leu Phe His Ala Ser Pro Leu Asn Arg Ile Ile Ser Thr Pro 65 70 75 80Ile Glu His Pro Gly Ile Leu Glu Thr Val Lys Ala Leu Glu Leu Gly

85 90 95Gly Ala Glu Ala Glu Leu Met Pro Ile Gly Pro Asp Gly Arg Val Ser

100 105 110Ser Phe Glu Ala Leu Asp Lys Pro Ala Ala Val Ala Thr Met Met Trp

115 120125Ala Asn Asn Glu Thr Gly Ala Ile Gln Pro Val Ser Glu Phe Ile Ala

130 135 140Ala Ala Gln Ala Ser Gly Thr Pro Thr His Ile Asp Ala Val Gln Val145 150 155 160Val Gly His Leu Pro Val Asn Phe Asp Glu Leu Gly Ala Thr Thr Leu

165 170 175Ala Ala Ser Ala His Lys Phe Gly Gly Pro Arg Gly Val Gly Leu Leu

180 185 190Leu Val Arg Arg Ser Pro Ala Pro Ser Ala Val Leu His Gly Gly Gly

195 200 205Gln Glu Arg Gly Ile Arg Pro Gly Thr Leu Asp Val Ala Gly Ala Ala

210 215 220Ala Thr Ala Ala Ala Leu Arg Glu Ala Val Ala Glu Leu Asp Gly Glu225 230 235 240Ala Thr Arg Leu Arg Gly Leu Lys Lys Met Leu Leu Asp Ala Ile Leu

245 250 255His Thr Ile Pro Asn Val Leu Val His Thr Thr Glu Pro Ser Leu Pro

260 265 270Gly His Leu His Leu Ser Phe Pro Gly Ala Glu Gly Asp Ser Leu Ile

275 280 285Met Leu Leu Asp Ser Leu Arg Ile Glu Ala Ser Thr Gly Ser Ala Cys

290 295 300Ser Asn Gly Val Asn Arg Ala Ser His Val Leu Leu Ala Met Gly Ile305 310 315 320Ser Glu Thr Asp Ala Arg Gly Ala Ile Arg Phe Thr Leu Gly Arg Thr

325 330 335Thr Thr Glu Glu Ser Ile Lys Ala Val Ile Ala Val Ile Glu Asp Val

340 345350Val Thr Arg Ala Arg Thr Ala Gly Met Ala Phe

355360<210>647<211>1197<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1174)<223>RXN00262<400>647acaccgcggg aaagattgca tcaaccggtg tcgacgtcat ttccgttgga gcgcttaccc 60attctgtgca tgcacttgac ctaggactcg atattttcta atg ctc tac ctt gat 115

Met Leu Tyr Leu Asp

1 5aat gca gcc acc acc agt gtg cgc aat gaa gca ctt gag gcc atg tgg 163Asn Ala Ala Thr Thr Ser Val Arg Asn Glu Ala Leu Glu Ala Met Trp

10 15 20cct tat ctc acc gga gcg ttt ggc aat ccg tca agt ccc cat gag gtg 211Pro Tyr Leu Thr Gly Ala Phe Gly Asn Pro Ser Ser Pro His Glu Val

25 30 35gga aga ctc gcc tct gcg ggg ctg gag gat gct cga act cgg gtg gcc 259Gly Arg Leu Ala Ser Ala Gly Leu Glu Asp Ala Arg Thr Arg Val Ala

40 45 50cgc att atc gga gga cgc ccc aca cag gtg acg ttt acg tcg ggt gga 307Arg Ile Ile Gly Gly Arg Pro Thr Gln Val Thr Phe Thr Ser Gly Gly

55 60 65rca gaa gcc aac aac ctc gct atc aaa gga gcg tgc tta gct aat cct 355Ser Glu Ala Asn Asn Leu Ala Ile Lys Gly Ala Cys Leu Ala Asn Pro 70 75 80 85cgt ggc cgg cac ctc atc acc acc ccg atc gag cat gac agt gtc cta 403Arg Gly Arg His Leu Ile Thr Thr Pro Ile Glu His Asp Ser Val Leu

90 95 100gaa act gct gct tat ctt gaa agg ttt cat gat ttc gag atc acc tac 451Glu Thr Ala Ala TyrLeu Glu Arg Phe His Asp Phe Glu Ile Thr Tyr

105 110 115cta tcc ccc gat cac act ggg ctg atc tcc ccg gag ggt ctc cgc aaa 499Leu Ser Pro Asp His Thr Gly Leu Ile Ser Pro Glu Gly Leu Arg Lys

120 125 130gca gtc agg ccg gac acc aca ttg atc agc att ggt tat gcc aac aat 547Ala Val Arg Pro Asp Thr Thr Leu Ile Ser Ile Gly Tyr Ala Asn Asn

135 140 145gag gtg gga acc att cag ccg ata gct gag ttg gcg gcg gta agc agt 595Glu Val Gly Thr Ile Gln Pro Ile Ala Glu Leu Ala Ala Val Ser Ser150 155 160 165acg cct ttt cac acc gat gca gtg caa gct gca cat tta acc ttt gac 643Thr Pro Phe His Thr Asp Ala Val Gln Ala Ala His Leu Thr Phe Asp

170 175 180ttg gga gtt gac gcg tta agt ttg tcg ggt cat aaa ttc ggt gcg cct 691Leu Gly Val Asp Ala Leu Ser Leu Ser Gly His Lys Phe Gly Ala Pro

185 190 195aaa ggg att gga gtg tta tgg tca aag ctt ccc ctg gag ccg gta atc 739Lys Gly Ile Gly Val Leu Trp Ser Lys Leu Pro Leu Glu Pro Val Ile

200 205 210cat ggc ggc ggc cag gaa aaa ggg cgg cgt agt ggc acg gaa aac gtt 787His Gly Gly Gly Gln Glu Lys Gly Arg Arg Ser Gly Thr Glu Asn Val

215 220 225gcg ggg gct atc gcc ttt gcc act gcc ttg gaa ttg gcc agg gcg gaa 835Ala Gly Ala Ile Ala Phe Ala Thr Ala Leu Glu Leu Ala Arg Ala Glu230 235 240 245tcc tat cca gat ctt ggc gaa ttc atc gag gaa gtt ctc act atc ccg 883Ser Tyr Pro Asp Leu Gly Glu Phe Ile Glu Glu Val Leu Thr Ile Pro

250255 260gga gca cac ctg act gga cat cct agg atg cgc att gat gga cac gca 931Gly Ala His Leu Thr Gly His Pro Arg Met Arg Ile Asp Gly His Ala

265 270 275tct ttt ctc ttc gac agc ata gga tct gaa act gtt ctt ctg gaa ttg 979Ser Phe Leu Phe Asp Ser Ile Gly Ser Glu Thr Val Leu Leu Glu Leu

280 285 290gaa cgc caa ggc att gtg tgc tcc cct ggt tct gcc tgt ggt tcc gga 1027Glu Arg Gln Gly Ile Val Cys Ser Pro Gly Ser Ala Cys Gly Ser Gly

295 300 305gag gta tcc cat gtg ttg ctg gcg ttg ggg ctt gag gag gat caa gca 1075Glu Val Ser His Val Leu Leu Ala Leu Gly Leu Glu Glu Asp Gln Ala310 315 320 325cga acg gct gtg cgc tgt act ttt agt aca aca cac agc cgt gaa gat 1123Arg Thr Ala Val Arg Cys Thr Phe Ser Thr Thr His Ser Arg Glu Asp

330 335 340gcg ctc gtg gca gcc tct gct ctt aaa tcc gcg gtc gcc tta atc aga 1171Ala Leu Val Ala Ala Ser Ala Leu Lys Ser Ala Val Ala Leu Ile Arg

345350355 ggg tgacgctagt cagaggttta cgg 1197Gly<210>648<211>358<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>648Met Leu Tyr Leu Asp Asn Ala Ala Thr Thr Ser Val Arg Asn Glu Ala 151015 Leu Glu Ala Met Trp Pro Tyr Leu Thr Gly Ala Phe Gly Asn Pro Ser

20 25 30Ser Pro His Glu Val Gly Arg Leu Ala Ser Ala Gly Leu Glu Asp Ala

35 40 45Arg Thr Arg Val Ala Arg Ile Ile Gly Gly Arg Pro Thr Gln Val Thr

50 55 60Phe Thr Ser Gly Gly Ser Glu Ala Asn Asn Leu Ala Ile LysGly Ala 65 70 75 80Cys Leu Ala Asn Pro Arg Gly Arg His Leu Ile Thr Thr Pro Ile Glu

85 90 95His Asp Ser Val Leu Glu Thr Ala Ala Tyr Leu Glu Arg Phe His Asp

100 105 110Phe Glu Ile Thr Tyr Leu Ser Pro Asp His Thr Gly Leu Ile Ser Pro

115 120 125Glu Gly Leu Arg Lys Ala Val Arg Pro Asp Thr Thr Leu Ile Ser Ile

130 135 140Gly Tyr Ala Asn Asn Glu Val Gly Thr Ile Gln Pro Ile Ala Glu Leu145 150 155 160Ala Ala Val Ser Ser Thr Pro Phe His Thr Asp Ala Val Gln Ala Ala

165 170 175His Leu Thr Phe Asp Leu Gly Val Asp Ala Leu Ser Leu Ser Gly His

180 185 190Lys Phe Gly Ala Pro Lys Gly Ile Gly Val Leu Trp Ser Lys Leu Pro

195 200 205Leu Glu Pro Val Ile His Gly Gly Gly Gln Glu Lys Gly Arg Arg Ser

210 215 220Gly Thr Glu Asn Val Ala Gly Ala Ile Ala Phe Ala Thr Ala Leu Glu225 230 235 240Leu Ala Arg Ala Glu Ser Tyr Pro Asp Leu Gly Glu Phe Ile Glu Glu

245 250 255Val Leu Thr Ile Pro Gly Ala His Leu Thr Gly His Pro Arg Met Arg

260 265 270Ile Asp Gly His Ala Ser Phe Leu Phe Asp Ser Ile Gly Ser Glu Thr

275 280 285Val Leu Leu Glu Leu Glu Arg Gln GlyIle Val Cys Ser Pro Gly Ser

290 295 300Ala Cys Gly Ser Gly Glu Val Ser His Val Leu Leu Ala Leu Gly Leu305 310 315 320Glu Glu Asp Gln Ala Arg Thr Ala Val Arg Cys Thr Phe Ser Thr Thr

325 330 335His Ser Arg Glu Asp Ala Leu Val Ala Ala Ser Ala Leu Lys Ser Ala

340 345 350Val Ala Leu Ile Arg Gly

355<210>649<211>920<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(79). (897)<223>FRXA00262<400>649cacacaggtg acgtttacgt cgggtggatc agaagccaac aacctcgctt atcaaaggag 60cgtgcttagc taatccta gtg gcc ggg cac ctc atc acc acc ccg atc gag 111

Val Ala Gly His Leu Ile Thr Thr Pro Ile Glu

1 5 10cat gac agt gtc cta gaa act gct gct tat ctt gaa agg ttt cat gat 159His Asp Ser Val Leu Glu Thr Ala Ala Tyr Leu Glu Arg Phe His Asp

15 20 25ttc gag atc acc tac cta tcc ccc gat cac act ggg ctg atc tcc ccg 207Phe Glu Ile Thr Tyr Leu Ser Pro Asp His Thr Gly Leu Ile Ser Pro

30 35 40gag ggt ctc cgc aaa gca gtc agg ccg gac acc aca ttg atc agc att 255Glu Gly Leu Arg Lys Ala Val Arg Pro Asp Thr Thr Leu Ile Ser Ile

45 50 55ggt tat gcc aac aat gag gtg gga acc att cag ccg ata gct gag ttg 303Gly Tyr Ala Asn Asn Glu Val Gly Thr Ile Gln Pro Ile Ala Glu Leu 60 65 70 75gcg gcg gta agc agt acg cct ttt cac acc gat gca gtg caa gct gca 351Ala Ala Val Ser Ser Thr Pro Phe His Thr Asp Ala Val Gln Ala Ala

80 85 90cat tta acc ttt gac ttg gga gtt gac gcg tta agt ttg tcg ggt cat 399His Leu Thr Phe Asp Leu Gly Val Asp Ala Leu Ser Leu Ser Gly His

95 100 105aaa ttc ggt gcg cct aaa ggg att gga gtg tta tgg tca aag ctt ccc 447Lys Phe Gly Ala Pro Lys Gly Ile Gly Val Leu Trp Ser Lys Leu Pro

110 115 120ctg gag ccg gta atc cat ggc ggc ggc cag gaa aaa ggg cgg cgt agt 495Leu Glu Pro Val Ile His Gly Gly Gly Gln Glu Lys Gly Arg Arg Ser

125 130 135ggc acg gaa aac gtt gcg ggg gct atc gcc ttt gcc act gcc ttg gaa 543Gly Thr Glu Asn Val Ala Gly Ala Ile Ala Phe Ala Thr Ala Leu Glu140 145 150 155ttg gcc agg gcg gaa tcc tat cca gat ctt ggc gaa ttc atc gag gaa 591Leu Ala Arg Ala Glu Ser Tyr Pro Asp Leu Gly Glu Phe Ile Glu Glu

160 165 170gtt ctc act atc ccg gga gca cac ctg act gga cat cct agg atg cgc 639Val Leu Thr Ile Pro Gly Ala His Leu Thr Gly His Pro Arg Met Arg

175 180 185att gat gga cac gca tct ttt ctc ttc gac agc ata gga tct gaa act 687Ile Asp Gly His Ala Ser Phe Leu Phe Asp Ser Ile Gly Ser Glu Thr

190 195 200gtt ctt ctg gaa ttg gaa cgc caa ggc att gtg tgc tcc cct ggt tct 735Val Leu Leu Glu Leu Glu Arg Gln Gly Ile Val Cys Ser Pro Gly Ser

205 210 215gcc tgt ggt tcc gga gag gta tcc cat gtg ttg ctg gcg ttg ggg ctt 783Ala Cys Gly Ser Gly Glu Val Ser His Val Leu Leu AlaLeu Gly Leu220 225 230 235gag gag gat caa gca cga acg gct gtg cgc tgt act ttt agt aca aca 831Glu Glu Asp Gln Ala Arg Thr Ala Val Arg Cys Thr Phe Ser Thr Thr

240 245 250cac agc cgt gaa gat gcg ctc gtg gca gcc tct gct ctt aaa tcc gcg 879His Ser Arg Glu Asp Ala Leu Val Ala Ala Ser Ala Leu Lys Ser Ala

255 260 265gtc gcc tta atc aga ggg tgacgctagt cagaggttta cgg 920Val Ala Leu Ile Arg Gly

270<210>650<211>273<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>650Val Ala Gly His Leu Ile Thr Thr Pro Ile Glu His Asp Ser Val Leu 151015 Glu Thr Ala Ala Tyr Leu Glu Arg Phe His Asp Phe Glu Ile Thr Tyr

20 25 30Leu Ser Pro Asp His Thr Gly Leu Ile Ser Pro Glu Gly Leu Arg Lys

35 40 45Ala Val Arg Pro Asp Thr Thr Leu Ile Ser Ile Gly Tyr Ala Asn Asn

50 55 60Glu Val Gly Thr Ile Gln Pro Ile Ala Glu Leu Ala Ala Val Ser Ser 65 70 75 80Thr Pro Phe His Thr Asp Ala Val Gln Ala Ala His Leu Thr Phe Asp

85 90 95Leu Gly Val Asp Ala Leu Ser Leu Ser Gly His Lys Phe Gly Ala Pro

100 105 110Lys Gly Ile Gly Val Leu Trp Ser Lys Leu Pro Leu Glu Pro Val Ile

115 120 125His Gly Gly Gly Gln Glu Lys Gly Arg Arg Ser Gly Thr Glu Asn Val

130 135140Ala Gly Ala Ile Ala Phe Ala Thr Ala Leu Glu Leu Ala Arg Ala Glu145 150 155 160Ser Tyr Pro Asp Leu Gly Glu Phe Ile Glu Glu Val Leu Thr Ile Pro

165 170 175Gly Ala His Leu Thr Gly His Pro Arg Met Arg Ile Asp G1y His Ala

180 185 190Ser Phe Leu Phe Asp Ser Ile Gly Ser Glu Thr Val Leu Leu Glu Leu

195 200 205Glu Arg Gln Gly Ile Val Cys Ser Pro Gly Ser Ala Cys Gly Ser Gly

210 215 220Glu Val Ser His Val Leu Leu Ala Leu Gly Leu Glu Glu Asp Gln Ala225 230 235 240Arg Thr Ala Val Arg Cys Thr Phe Ser Thr Thr His Ser Arg Glu Asp

245 250 255Ala Leu Val Ala Ala Ser Ala Leu Lys Ser Ala Val Ala Leu Ile Arg

260265270 Gly<210>651<211>1296<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1273)<223>RXN00435<400>651cgacaggtga attcatgcac gtttgagtgt cccgtgtgtg gggtaatgtt gtccaagaga 60gtggaaggaa atgctgtggc ggttgaaagg agtgcctttc gtg ggt ttt gat gtg 115

Val Gly Phe Asp Val

1 5gcc agg gtt cgg ggg ctt tat acc tct ttg ggc gat ggc tgg acg tac 163Ala Arg Val Arg Gly Leu Tyr Thr Ser Leu Gly Asp Gly Trp Thr Tyr

10 15 20ctt aat tca cat caa att ccg cag gtt ccg gag cgg gtg gcg tcg gga 211Leu Asn Ser His Gln Ile Pro Gln Val Pro Glu Arg Val Ala Ser Gly

25 30 35gtt gcg gcg gct ttc cgc acg cat gcg cag att tct gag gtg acg tcg 259Val Ala Ala Ala Phe Arg Thr His Ala Gln Ile Ser Glu Val Thr Ser

40 45 50cag ccg att gcg gtg gat cag ttg gag gct gct cgc gag gca gtt gcg 307Gln Pro Ile Ala Val Asp Gln Leu Glu Ala Ala Arg Glu Ala Val Ala

55 60 65tcg ttg gcg ggt gtg gat ccg gac tgt gtt gtg ctg ggt ccc acg agg 355Ser Leu Ala Gly Val Asp Pro Asp Cys Val Val Leu Gly Pro Thr Arg 70 75 80 85cag ttt ttg gct cat aca ttg gcg cgc ggt ttg ggt ggg ttt gta cgt 403Gln Phe Leu Ala His Thr Leu Ala Arg Gly Leu Gly Gly Phe Val Arg

90 95 100cga aaa gcg ggc gtg gtg ttg tcg cgc gcg gac gcg gac tgg ctg acc 451Arg Lys Ala Gly Val Val Leu Ser Arg Ala Asp Ala Asp Trp Leu Thr

105 110 115gcg ccg ttc cgc tcc ctc gac ggc gtt ttt agc tgg gcc gag ccc gat 499Ala Pro Phe Arg Ser Leu Asp Gly Val Phe Ser Trp Ala Glu Pro Asp

120 125 130ttg ggc acc ggc atg ctg ccg gat tgg cag tac gag aag ctt gtt gac 547Leu Gly Thr Gly Met Leu Pro Asp Trp Gln Tyr Glu Lys Leu Val Asp

135 140 145ggc tcg acg cgc ctt gtc gtg ctc agc gcc gcg cac ccg ctg ctc ggc 595Gly Ser Thr Arg Leu Val Val Leu Ser Ala Ala His Pro Leu Leu Gly150 155 160 165acg gtc gcc cca gtg ggc aag att gtg gat aaa gtg cgg gcg cgt tcg 643Thr Val Ala Pro Val Gly Lys Ile Val Asp Lys Val Arg Ala Arg Ser

170 175 180cgt gcc tgg gtgctt gtc gac gcc acc acc tac gca gcc tac cgc ccc 691Arg Ala Trp Val Leu Val Asp Ala Thr Thr Tyr Ala Ala Tyr Arg Pro

185 190 195ctg cgc cta gac gag tgg gaa gcc gat atc gtc atg cLt gat ctc ggc 739Leu Arg Leu Asp Glu Trp Glu Ala Asp Ile Val Met Leu Asp Leu Gly

200 205 210gag ttg ggc ggc ccg cag att tcg gcg ttg att ttc cgt gat acc tcg 787Glu Leu Gly Gly Pro Gln Ile Ser Ala Leu Ile Phe Arg Asp Thr Ser

215 220 225atg ttc ccg cgc ctg gat cgc acc gtt cca ctc gaa ctg ccc gca agc 835Met Phe Pro Arg Leu Asp Arg Thr Val Pro Leu Glu Leu Pro Ala Ser230 235 240 245tcc ctg ccg cat ggg ctg ctc ggc ggc gtg ccc aac ctg gtg cgg cac 883Ser Leu Pro His Gly Leu Leu Gly Gly Val Pro Asn Leu Val Arg His

250 255 260ctg gga aac ctg gat gaa aac gcc ccg tcc gtc gtt gag gcg atg ggg 931Leu Gly Asn Leu Asp Glu Asn Ala Pro Ser Val Val Glu Ala Met Gly

265 270 275gag atg gcg aaa ttc cac aag gga ctt ttt gag cat ctt gtg gaa tcg 979Glu Met Ala Lys Phe His Lys Gly Leu Phe Glu His Leu Val Glu Ser

280 285 290ctc gaa gga ctt cac gcg gtg cat atc gtg gga att tcc ggc gat gcc 1027Leu Glu Gly Leu His Ala Val His Ile ValGly Ile Ser Gly Asp Ala

295 300 305gca ggt caa gac gcc ccg ttc ctg gat cga gtg ccc cgc ttg acc ttc 1075Ala Gly Gln Asp Ala Pro Phe Leu Asp Arg Val Pro Arg Leu Thr Phe310 315 320 325acc atg gaa ggc gtg ccc gca gat atg gtg tac cgc cga ttg gtg gac 1123Thr Met Glu Gly Val Pro Ala Asp Met Val Tyr Arg ArgLeu Val Asp

330 335 340aat cgt ttg atc act acc gtc agc cct gct gac ccg ctg ctc gaa gca 1171Asn Arg Leu Ile Thr Thr Val Ser Pro Ala Asp Pro Leu Leu Glu Ala

345 350 355atg ggt gtg act gaa gct ggc gga tcg atc act atc gga cta agc ccg 1219Met Gly Val Thr Glu Ala Gly Gly Ser Ile Thr Ile Gly Leu Ser Pro

360 365 370ttt agc acc tac tat gaa gtg gat cag ctg acc agg gtg ctg gca tcg 1267Phe Ser Thr Tyr Tyr Glu Val Asp Gln Leu Thr Arg Val Leu Ala Ser

375380385 ctt gcc taaaccgcaa gcacgagctt gcc 1296Leu Ala390<210>652<211>391<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>652Val Gly Phe Asp Val Ala Arg Val Arg Gly Leu Tyr Thr Ser Leu Gly 151015 Asp Gly Trp Thr Tyr Leu Asn Ser His Gln Ile Pro Gln Val Pro Glu

20 25 30Arg Val Ala Ser Gly Val Ala Ala Ala Phe Arg Thr His Ala Gln Ile

35 40 45Ser Glu Val Thr Ser Gln Pro Ile Ala Val Asp Gln Leu Glu Ala Ala

50 55 60Arg Glu Ala Val Ala Ser Leu Ala Gly Val Asp Pro Asp Cys Val Val 65 70 75 80Leu Gly Pro Thr Arg Gln Phe Leu Ala His Thr Leu Ala Arg Gly Leu

85 90 95Gly Gly Phe Val Arg Arg Lys Ala Gly Val Val Leu Ser Arg Ala Asp

100 105 110Ala Asp Trp Leu Thr Ala Pro Phe Arg Ser Leu Asp Gly Val Phe Ser

115 120 125Trp Ala Glu Pro Asp Leu Gly Thr Gly Met Leu Pro Asp Trp Gln Tyr

130 135 140Glu Lys Leu Val Asp Gly Ser Thr Arg Leu Val Val Leu Ser Ala Ala145 150 155 160His Pro Leu Leu Gly Thr Val Ala Pro Val Gly Lys Ile Val Asp Lys

165 170 175Val Arg Ala Arg Ser Arg Ala Trp Val Leu Val Asp Ala Thr Thr Tyr

180 185 190Ala Ala Tyr Arg Pro Leu Arg Leu Asp Glu Trp Glu Ala Asp Ile Val

195 200 205Met Leu Asp Leu Gly Glu Leu Gly Gly Pro Gln Ile Ser Ala Leu Ile

210 215 220Phe Arg Asp Thr Ser Met Phe Pro Arg Leu Asp Arg Thr Val Pro Leu225 230 235 240Glu Leu Pro Ala Ser Ser Leu Pro His Gly Leu Leu Gly Gly Val Pro

245 250 255Asn Leu Val Arg His Leu Gly Asn Leu Asp Glu Asn Ala Pro Ser Val

260 265 270Val Glu Ala Met Gly Glu Met Ala Lys Phe His Lys Gly Leu Phe Glu

275 280 285His Leu Val Glu Ser Leu Glu Gly Leu His Ala Val His Ile Val Gly

290 295 300Ile Ser Gly Asp Ala Ala Gly Gln Asp Ala Pro Phe Leu Asp Arg Val305 310 315 320Pro Arg Leu Thr Phe Thr Met Glu Gly Val Pro Ala Asp Met Val Tyr

325 330 335Arg Arg Leu Val Asp Asn Arg Leu Ile Thr Thr Val Ser Pro Ala Asp

340 345 350Pro Leu Leu Glu Ala Met Gly Val Thr Glu Ala Gly Gly Ser Ile Thr

355 360 365Ile Gly Leu Ser Pro Phe Ser Thr Tyr Tyr Glu Val Asp Gln Leu Thr

370375380 Arg Val Leu Ala Ser Leu Ala 385390<210>653<211>638<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1).<615)<223>FRXA00435<400>653gtc gac gcc acc acc tac gca gcc tac cgc ccc ctg cgc cta gac gag 48Val Asp Ala Thr Thr Tyr Ala Ala Tyr Arg Pro Leu Arg Leu Asp Glu 151015 tgg gaa gcc gat atc gtc atg ctt gat ctc ggc gag ttg ggc ggc ccg 96Trp Glu Ala Asp Ile Val Met Leu Asp Leu Gly Glu Leu Gly Gly Pro<400>653gtc gac gcc acc acc tac gca gcc tac cgc ccc ctg cgc cta gac gag

20 25 30cag att tcg gcg ttg att ttc cgt gat acc tcg atg ttc ccg cgc ctg 144Gln Ile Ser Ala Leu Ile Phe Arg Asp Thr Ser Met Phe Pro Arg Leu

35 40 45gat cgc acc gtt cca ctc gaa ctg ccc gca agc tcc ctg ccg cat ggg 192Asp Arg Thr Val Pro Leu Glu Leu Pro Ala Ser Ser Leu Pro His Gly

50 55 60ctg ctc ggc ggc gtg ccc aac ctg gtg cgg cac ctg gga aac ctg gat 240Leu Leu Gly Gly Val Pro Asn Leu Val Arg His Leu Gly Asn Leu Asp 65 70 75 80gaa aac gcc ccg tcc gtc gtt gag gcg atg ggg gag atg gcg aaa ttc 288Glu Asn Ala Pro Ser Val Val Glu Ala Met Gly Glu Met Ala Lys Phe

85 90 95cac aag gga ctt ttt gag cat ctt gtg gaa tcg ctc gaa gga ctt cac 336His Lys Gly Leu Phe Glu His Leu Val Glu Ser Leu Glu Gly Leu His

100 105 110gcg gtg cat atc gtg gga att tcc ggc gatgcc gca ggt caa gac gcc 384Ala Val His Ile Val Gly Ile Ser Gly Asp Ala Ala Gly Gln Asp Ala

115 120 125ccg ttc ctg gat cga gtg ccc cgc ttg acc ttc acc atg gaa ggc gtg 432Pro Phe Leu Asp Arg Val Pro Arg Leu Thr Phe Thr Met Glu Gly Val

130 135 140ccc gca gat atg gtg tac cgc cga ttg gtg gac aat cgt ttg atc act 480Pro Ala Asp Met Val Tyr Arg Arg Leu Val Asp Asn Arg Leu Ile Thr145 150 155 160acc gtc agc cct gct gac ccg ctg ctc gaa gca atg ggt gtg act gaa 528Thr Val Ser Pro Ala Asp Pro Leu Leu Glu Ala Met Gly Val Thr Glu

165 170 175gct ggc gga tcg atc act atc gga cta agc ccg ttt agc acc tac tat 576Ala Gly Gly Ser Ile Thr Ile Gly Leu Ser Pro Phe Ser Thr Tyr Tyr

180 185 190gaa gtg gat cag ctg acc agg gtg ctg gca tcg ctt gcc taaaccgcaa 625Glu Val Asp Gln Leu Thr Arg Val Leu Ala Ser Leu Ala

195200205 gcacgagctt gcc 638<210>654<211>205<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>654Val Asp Ala Thr Thr Tyr Ala Ala Tyr Arg Pro Leu Arg Leu Asp Glu 151015 Trp Glu Ala Asp Ile Val Met Leu Asp Leu Gly Glu Leu Gly Gly Pro

20 25 30Gln Ile Ser Ala Leu Ile Phe Arg Asp Thr Ser Met Phe Pro Arg Leu

35 40 45Asp Arg Thr Val Pro Leu Glu Leu Pro Ala Ser Ser Leu Pro His Gly

50 55 60Leu Leu Gly Gly Val Pro Asn Leu Val Arg His Leu Gly Asn Leu Asp 65 70 75 80Glu Asn Ala Pro Ser Val Val Glu Ala Met Gly Glu Met Ala Lys Phe

85 90 95His Lys Gly Leu Phe Glu His Leu Val Glu Ser Leu Glu Gly Leu His

100 105 110Ala Val His Ile Val Gly Ile Ser Gly Asp Ala Ala Gly Gln Asp Ala

115 120 125Pro Phe Leu Asp Arg Val Pro Arg Leu Thr Phe Thr Met Glu Gly Val

130 135 140Pro Ala Asp Met Val Tyr Arg Arg Leu Val Asp Asn Arg Leu Ile Thr145 150 155 160Thr Val Ser Pro Ala Asp Pro Leu Leu Glu Ala Met Gly Val Thr Glu

165 170 175Ala Gly Gly Ser Ile Thr Ile Gly Leu Ser Pro Phe Ser Thr Tyr Tyr

180 185 190Glu Val Asp Gln Leu Thr Arg Val Leu Ala Ser Leu Ala

195200205<210>655<211>535<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (535)<223>FRXA02801<400>655cgacaggtga attcatgcac gtttgagtgt cccgtgtgtg gggtaatgtt gtccaagaga 60gtggaaggaa atgctgtggc ggttgaaagg agtgcctttc gtg ggt ttt gat gtg 115

Val Gly Phe Asp Val

1 5gcc agg gtt cgg ggg ctt tat acc tct ttg ggc gat ggc tgg acg tac 163Ala Arg Val Arg Gly Leu Tyr Thr Ser Leu Gly Asp Gly Trp Thr Tyr

10 15 20ctt aat tca cat caa att ccg cag gtt ccg gag cgg gtg gcg tcg gga 211Leu Asn Ser His Gln Ile Pro Gln Val Pro Glu Arg Val Ala Ser Gly

25 30 35gtt gcg gcg gct ttc cgc acg cat gcg cag att tct gag gtg acg tcg 259Val Ala Ala Ala Phe Arg Thr His Ala Gln Ile Ser Glu Val Thr Ser

40 45 50cag ccg att gcg gtg gat cag ttg gag gct gct cgc gag gca gtt gcg 307Gln Pro Ile Ala Val Asp Gln Leu Glu Ala Ala Arg Glu Ala Val Ala

55 60 65tcg ttg gcg ggt gtg gat ccg gac tgt gtt gtg ctg ggt ccc acg agg 355Ser Leu Ala Gly Val Asp Pro Asp Cys Val Val Leu Gly Pro Thr Arg 70 75 80 85cag ttt ttg gct cat aca ttg gcg cgc ggt ttg ggt ggg ttt gta cgt 403Gln Phe Leu Ala His Thr Leu Ala Arg Gly Leu Gly Gly Phe Val Arg

90 95 100cga aaa gcg ggc gtg gtg ttg tcg cgc gcg gac gcg gac tgg ctg acc 451Arg Lys Ala Gly Val Val Leu Ser Arg Ala Asp Ala Asp Trp Leu Thr

105 110 115gcg ccg ttc cgc tcc ctc gac ggc gtt ttt agc tgg gcc gag ccc gat 499Ala Pro Phe Arg Ser Leu Asp Gly Val Phe Ser Trp Ala Glu Pro Asp

120 125 130ttg ggc acc ggc atg ctg ccg gat tgg cag tac cag 535Leu Gly Thr Gly Met Leu Pro Asp Trp Gln Tyr Gln

135140145<210>656<211>145<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>656Val Gly Phe Asp Val Ala Arg Val Arg Gly Leu Tyr Thr Ser Leu Gly 151015 Asp Gly Trp Thr Tyr Leu Asn Ser His Gln Ile Pro Gln Val Pro Glu

20 25 30Arg Val Ala Ser Gly Val Ala Ala Ala Phe Arg Thr His Ala Gln Ile

35 40 45Ser Glu Val ThrSer Gln Pro Ile Ala Val Asp Gln Leu Glu Ala Ala

50 55 60Arg Glu Ala Val Ala Ser Leu Ala Gly Val Asp Pro Asp Cys Val Val 65 70 75 80Leu Gly Pro Thr Arg Gln Phe Leu Ala His Thr Leu Ala Arg Gly Leu

85 90 95Gly Gly Phe Val Arg Arg Lys Ala Gly Val Val Leu Ser Arg Ala Asp

100 105 110Ala Asp Trp Leu Thr Ala Pro Phe Arg Ser Leu Asp Gly Val Phe Ser

115 120 125Trp Ala Glu Pro Asp Leu Gly Thr Gly Met Leu Pro Asp Trp Gln Tyr

130135140 Gln145<210>657<211>1386<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1363)<223>RXA02516<400>657ttcattcacg ttttcgcgaa tggccagatt gtgaccaccg gtggcgctga gcttgctgac 60aagctcgagg ctgacggcta cgaccagttc atcaagtaac atg tcc gat ttc ctc 115

Met Ser Asp Phe Leu

1 5aat gca gat gga tcc ctc aat gtg gat aag gtg cgg gaa gaa ttc cca 163Asn Ala Asp Gly Ser Leu Asn Val Asp Lys Val Arg Glu Glu Phe Pro

10 15 20atc ctg aag cgc act gtt agg gat ggg aaa ccg ctt gct tac ctg gac 211Ile Leu Lys Arg Thr Val Arg Asp Gly Lys Pro Leu Ala Tyr Leu Asp

25 30 35tca ggt gcg aca tcg cag cga ccc gag cgg gtg tgg cgt gca gag gag 259Ser Gly Ala Thr Ser Gln Arg Pro Glu Arg Val Trp Arg Ala Glu Glu

40 45 50cac ttt gtg ctg cac acc aac gcc ccc gtg cac cgc ggt gcc tac caa 307His Phe Val Leu His Thr Asn Ala Pro Val His Arg Gly Ala Tyr Gln

55 60 65ctg gct gag gaa gca acg gat gct tat gaa ggt gcc cgc gag aag atc 355Leu Ala Glu Glu Ala Thr Asp Ala Tyr Glu Gly Ala Arg Glu Lys Ile 70 75 80 85gct gcc ttt gtt ggt gcc gag cag cat gaa att gcg ttc act aag aat 403Ala Ala Phe Val Gly Ala Glu Gln His Glu Ile Ala Phe Thr Lys Asn

90 95 100gca act gaa gca ctc aat ctt gtt gcg tac acc ttg ggt gat gac cgt 451Ala Thr Glu Ala Leu Asn Leu Val Ala Tyr Thr Leu Gly Asp Asp Arg

105 110 115tcc ggt aag tat cgt gtc cag gcc ggg gat acc gtg gtc atc acg gag 499Ser Gly Lys Tyr Arg Val Gln Ala Gly Asp Thr Val Val Ile Thr Glu

120 125 130cta gag cac cac gca aac ttg gtg cca tgg cag gag ctg tgc cgt cga 547Leu Glu His His Ala Asn Leu Val Pro Trp Gln Glu Leu Cys Arg Arg

135 140 145acc ggt gcg aca ttg aag tgg tac aag gtg act gaa gat ggt cgc att 595Thr Gly Ala Thr Leu Lys Trp Tyr Lys Val Thr Glu Asp Gly Arg Ile150 155 160 165gat ctc gat tca ctc gag ctt gat gaa act gtc aag gtc gtt gcc ttc 643Asp Leu Asp Ser Leu Glu Leu Asp Glu Thr Val Lys Val Val Ala Phe

170 175 180act cac cag tcc aat gtg acc ggt gct gtg gct gat gtt cca gag ttg 691Thr His Gln Ser Asn Val Thr Gly Ala Val Ala Asp Val Pro Glu Leu

185 190 195gtt cgt cgt gcc aag gct gtc ggc gct ctc acg gtg ctt gat gcg tgc 739Val Arg Arg Ala Lys Ala Val Gly Ala Leu Thr Val Leu Asp Ala Cys

200 205 210cag tct gtt cct cat atg cca gtg aat ttc cac gag ctg gat gta gat 787Gln Ser Val Pro His Met Pro Val Asn Phe His Glu Leu Asp Val Asp

215 220 225ttc tct gca ttc tct ggc cat aag atg ctg gga cct gca ggc gtg ggc 835Phe Ser Ala Phe Ser Gly His Lys Met Leu Gly Pro Ala Gly Val Gly230 235 240 245gtt gtg tat gca aag tcc cca atc ttg gat gaa ctg cca cca ttt ttg 883Val Val Tyr Ala Lys Ser Pro Ile Leu Asp Glu Leu Pro Pro Phe Leu

250 255 260act ggt ggt tcc atg att gaa gtt gtc acc atg gag ggt tcc acc tac 931Thr Gly Gly Ser Met Ile Glu Val Val Thr Met Glu Gly Ser Thr Tyr

265 270 275gct gcc gca cct caa cgt ttt gag gcc ggc acg cag atg acc agc cag 979Ala Ala Ala Pro Gln Arg Phe Glu Ala Gly Thr Gln Met Thr Ser Gln

280 285 290gtt gtg ggc ttg ggt gct gcc gtg gac atg ctg aat gaa atc ggt atg 1027Val Val Gly Leu Gly Ala Ala Val Asp Met Leu Asn Glu Ile Gly Met

295 300 305gaa gca atc gca gcg cat gag cac gca ttg act gct tac gcg ttg gaa 1075Glu Ala Ile Ala Ala His Glu His Ala Leu Thr Ala Tyr Ala Leu Glu310 315 320 325aag ctc acg gca att aag gga cta acc att gct ggt cct ttg act gca 1123Lys Leu Thr Ala Ile Lys Gly Leu Thr Ile Ala Gly Pro Leu Thr Ala

330 335 340gag cag cgc ggc ggt gca atc agc ttc ggt gtc gag ggc att cac cca 1171Glu Gln Arg Gly Gly Ala Ile Ser Phe Gly Val Glu Gly Ile His Pro

345350 355cac gat cta ggc caa gtg ctt gac gat cag ggc gtg aat atc cgc gtc 1219His Asp Leu Gly Gln Val Leu Asp Asp Gln Gly Val Asn Ile Arg Val

360 365 370ggc cac cac tgc gcg tgg ccc gtg cac cgc agc atg aac gta caa tcg 1267Gly His His Cys Ala Trp Pro Val His Arg Ser Met Asn Val Gln Ser

375 380 385aca gca aga gca tct ttc tat ctc tat aac acc ttc gaa gaa atc gac 1315Thr Ala Arg Ala Ser Phe Tyr Leu Tyr Asn Thr Phe Glu Glu Ile Asp390 395 400 405cgc ctc gcg gca gcg atc gag aag gcc aag caa ttc ttt gga gtt gag 1363Arg Leu Ala Ala Ala Ile Glu Lys Ala Lys Gln Phe Phe Gly Val Glu

410415420 taatgaacct tgagcagatg tac 1386<210>658<211>421<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>658Met Ser Asp Phe Leu Asn Ala Asp Gly Ser Leu Asn Val Asp Lys Val 151015 Arg Glu Glu Phe Pro Ile Leu Lys Arg Thr Val Arg Asp Gly Lys Pro

20 25 30Leu Ala Tyr Leu Asp Ser Gly Ala Thr Ser Gln Arg Pro Glu Arg Val

35 40 45Trp Arg Ala Glu Glu His Phe Val Leu His Thr Asn Ala Pro Val His

50 55 60Arg Gly Ala Tyr Gln Leu Ala Glu Glu Ala Thr Asp Ala Tyr Glu Gly 65 70 75 80Ala Arg Glu Lys Ile Ala Ala Phe Val Gly Ala Glu Gln His Glu Ile

85 90 95Ala Phe Thr Lys Asn Ala Thr Glu Ala Leu Asn Leu Val Ala Tyr Thr

100 105 110Leu Gly Asp Asp Arg Ser Gly Lys Tyr Arg Val Gln Ala Gly Asp Thr

115 120 125Val Val Ile Thr Glu Leu Glu His His Ala Asn Leu Val Pro Trp Gln

130 135 140Glu Leu Cys Arg Arg Thr Gly Ala Thr Leu Lys Trp Tyr Lys Val Thr145 150 155 160Glu Asp Gly Arg Ile Asp Leu Asp Ser Leu Glu Leu Asp Glu Thr Val

165 170 175Lys Val Val Ala Phe Thr His Gln Ser Asn Val Thr Gly Ala Val Ala

180 185 190Asp Val Pro Glu Leu Val Arg Arg Ala Lys Ala Val Gly Ala Leu Thr

195 200 205Val Leu Asp Ala Cys Gln Ser Val Pro His Met Pro Val Asn Phe His

210 215 220Glu Leu Asp Val Asp Phe Ser Ala Phe Ser Gly His Lys Met Leu Gly225 230 235 240Pro Ala Gly Val Gly Val Val Tyr Ala Lys Ser Pro Ile Leu Asp Glu

245 250 255Leu Pro Pro Phe Leu Thr Gly Gly Ser Met Ile Glu Val Val Thr Met

260 265 270Glu Gly Ser Thr Tyr Ala Ala Ala Pro Gln Arg Phe Glu Ala Gly Thr

275 280 285Gln Met Thr Ser Gln Val Val Gly Leu Gly Ala Ala Val Asp Met Leu

290 295 300Asn Glu Ile Gly Met Glu Ala Ile Ala Ala His Glu His Ala Leu Thr305 310 315 320Ala Tyr Ala Leu Glu Lys Leu Thr Ala Ile Lys Gly Leu Thr Ile Ala

325 330 335Gly Pro Leu Thr Ala Glu Gln Arg Gly Gly Ala Ile Ser Phe Gly Val

340 345 350Glu Gly Ile His Pro His Asp Leu Gly Gln Val Leu Asp Asp Gln Gly

355 360 365Val Ash Ile Arg Val Gly His His Cys Ala Trp Pro Val His Arg Ser

370 375 380Met Asn Val Gln Ser Thr Ala Arg Ala Ser Phe Tyr Leu Tyr Asn Thr385 390 395 400Phe Glu Glu Ile Asp Arg Leu Ala Ala Ala Ile Glu Lys Ala Lys Gln

405 410 415Phe Phe Gly Val Glu

420<210>659<211>570<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (547)<223>RXA02517<400>659cgacagcaag agcatctttc tatctctata acaccttcga agaaatcgac cgcctcgcgg 60cagcgatcga gaaggccaag caattctttg gagttgagta atg aac ctt gag cag 115

Met Asn Leu Glu Gln

1 5atg tac cag gag gtg atc ctg gac cac tac aaa aac cca cag cac aag 163Met Tyr Gln Glu Val Ile Leu Asp His Tyr Lys Asn Pro Gln His Lys

10 15 20ggc ctt cgg gat cct ttc gat gct gag gtt cac cac gtc aac cct tct 211Gly Leu Arg Asp Pro Phe Asp Ala Glu Val His His Val Asn Pro Ser

25 30 35tgt ggc gac gaa ttg act ctg cgc gtg aag ctg tct gag gac ggc tcc 259Cys Gly Asp Glu Leu Thr Leu Arg Val Lys Leu Ser Glu Asp Gly Ser

40 45 50acc gtg gag gac gtc tcc tac gaa gca gtt ggt tgc tca atc agc cag 307Thr Val Glu Asp Val Ser Tyr Glu Ala Val Gly CysSer Ile Ser Gln

55 60 65gcc tcc acg tcc gtt atg gcc gag gag atc gtg ggc caa ccc gtc gac 355Ala Ser Thr Ser Val Met Ala Glu Glu Ile Val Gly Gln Pro Val Asp 70 75 80 85aag gcg ctg gaa aag ctc aca gaa ttt gag aag atg atc gtt tcc cgc 403Lys Ala Leu Glu Lys Leu Thr Glu Phe Glu Lys Met Ile Val Ser Arg

90 95 100ggt cag ttt gtt ggc gat gaa gat ctc atc gga gat ggc gtt gct ttc 451Gly Gln Phe Val Gly Asp Glu Asp Leu Ile Gly Asp Gly Val Ala Phe

105 110 115tcc gga gtc gcc aag tac ccg gca cgc gtg aag tgc gcg ctg ctt ggg 499Ser Gly Val Ala Lys Tyr Pro Ala Arg Val Lys Cys Ala Leu Leu Gly

120 125 130tgg aag gct ttc cag gcg gca acc gct gac gct gtt gcg cac gca cat 547Trp Lys Ala Phe Gln Ala Ala Thr Ala Asp Ala Val Ala His Ala His

135140145 tagcccgctg tattaattgg agg 570<210>660<211>149<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>660Met Asn Leu Glu Gln Met Tyr Gln Glu Val Ile Leu Asp His Tyr Lys 151015 Asn Pro Gln His Lys Gly Leu Arg Asp Pro Phe Asp Ala Glu Val His

20 25 30His Val Asn Pro Ser Cys Gly Asp Glu Leu Thr Leu Arg Val Lys Leu

35 40 45Ser Glu Asp Gly Ser Thr Val Glu Asp Val Ser Tyr Glu Ala Val Gly

50 55 60Cys Ser Ile Ser Gln Ala Ser Thr Ser Val Met Ala Glu Glu Ile Val 65 70 75 80Gly Gln Pro Val Asp Lys Ala Leu Glu Lys Leu Thr Glu Phe Glu Lys

85 90 95Met Ile Val Ser Arg Gly Gln Phe Val Gly Asp Glu Asp Leu Ile Gly

100 105 110Asp Gly Val Ala Phe Ser Gly Val Ala Lys Tyr Pro Ala Arg Val Lys

115 120 125Cys Ala Leu Leu Gly Trp Lys Ala Phe Gln Ala Ala Thr Ala Asp Ala

130135140 Val Ala His Ala His145<210>661<211>1167<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1144)<223>RXA01747<400>661cgaagtagag ccgattgcag aatcggcgga atgagacgtc gaaaagcgtt taagctttcc 60ctaaaaatat cactaactcg aaagatgtaa ggttgcattt gtg act atc gca cct 115

Val Thr Ile Ala Pro

1 5gaa gga cga cga ctg cta cgc gtc gaa gct cga aac tca gaa acc ccg 163Glu Gly Arg Arg Leu Leu Arg Val Glu Ala Arg Asn Ser Glu Thr Pro

10 15 20att gag acg aag cct cga tgg att aga aac cag gtc aaa aac gga cct 211Ile Glu Thr Lys Pro Arg Trp Ile Arg Asn Gln Val Lys Asn Gly Pro

25 30 35gag tat cag gat atg aag gaa cgt gtc gct ggc gca tca cta cac act 259Glu Tyr Gln Asp Met Lys Glu Arg Val Ala Gly Ala Ser Leu His Thr

40 45 50gtg tgt cag gag gct ggc tgt cct aat atc cat gag tgt tgg gaa tcc 307Val Cys Gln Glu Ala Gly Cys Pro Asn Ile His Glu Cys Trp Glu Ser

55 60 65cgt gag gca acc ttc ctc att ggt ggc gcc aac tgc tct cgc cgc tgt 355Arg Glu Ala Thr Phe Leu Ile Gly Gly Ala Asn Cys Ser Arg Arg Cys 70 75 80 85gat ttc tgc atg atc aac tcg gct cgc cct gag cca ctc gac cgc ggt 403Asp Phe Cys Met Ile Asn Ser Ala Arg Pro Glu Pro Leu Asp Arg Gly

90 95 100gag cca ctg cgt gtc gct gag tct gtt cgt gag atg cag ctg aat tac 451Glu Pro Leu Arg Val Ala Glu Ser Val Arg Glu Met Gln Leu Asn Tyr

105 110 115tcc acc atc acc ggt gtt acc cgt gat gat ctg gat gat gaa ggc gca 499Ser Thr Ile Thr Gly Val Thr Arg Asp Asp Leu Asp Asp Glu Gly Ala

120 125 130tgg ctg tac tca gaa gtg gtt cgt aag atc cac gag ctg aac cca cac 547Trp Leu Tyr Ser Glu Val Val Arg Lys Ile His Glu Leu Asn Pro His

135 140 145acc ggt gtg gaa aac ctg gtg cct gat ttc tcc ggc aag aag gat ctg 595Thr Gly Val Glu Asn Leu Val Pro Asp Phe Ser Gly Lys Lys Asp Leu150 155 160 165ctg cag gaa gtt ttt gaa tcc cgc cca gag gtt ttc gct cac aac gtg 643Leu Gln Glu Val Phe Glu Ser Arg Pro Glu Val Phe Ala His Asn Val

170 175 180gaa act gtg cca cgt att ttc aag cgc att cgc cca gca ttc cgc tac 691Glu Thr Val Pro Arg Ile Phe Lys Arg Ile Arg Pro Ala Phe Arg Tyr

185 190 195gag cgt tca ctt gat gtg atc cgt cag gct cgc gat ttc ggt ctg gtg 739Glu Arg Ser Leu Asp Val Ile Arg Gln Ala Arg Asp Phe Gly Leu Val

200 205 210acc aag tcc aac ctg att ttg ggc atg ggt gaa acc aag gaa gaa atc 787Thr Lys Ser Asn Leu Ile Leu Gly Met Gly Glu Thr Lys Glu Glu Ile

215 220 225acc gag gcg ctg cag gat ctg cac gac gct ggc tgt gac atc atc acc 835Thr Glu Ala Leu Gln Asp Leu His Asp Ala Gly Cys Asp Ile Ile Thr230 235 240 245atc acc cag tac ctg cgt cct ggt cct ttg ttc cac ccc atc gag cgt 883Ile Thr Gln Tyr Leu Arg Pro Gly Pro Leu Phe His Pro Ile Glu Arg

250 255 260tgg gtg aag cct gag gag ttc ctc gag cac gct gat gct gca aag gaa 931Trp Val Lys Pro Glu Glu Phe Leu Glu His Ala Asp Ala Ala Lys Glu

265 270 275atg ggc ttc gct gct gtt atg tcc ggc cca ttg gtt cgt tcc tct tac 979Met Gly Phe Ala Ala Val Met Ser Gly Pro Leu Val Arg Ser Ser Tyr

280 285 290cgt gca ggc cgt ctg tac gcg cag gcc atg gag ttc cgt ggc gag gaa 1027Arg Ala Gly Arg Leu Tyr Ala Gln Ala Met Glu Phe Arg Gly Glu Glu

295 300 305atc cca gca cac ctc gcg cac ctg aag gat act tcc gga gga tcc acc 1075Ile Pro Ala His Leu Ala His Leu Lys Asp Thr Ser Gly Gly Ser Thr310 315 320 325gcc cag gaa gca tct aca ctt ctg gag cgt tac ggt gct tcc gaa gac 1123Ala Gln Glu Ala Ser Thr Leu Leu Glu Arg Tyr Gly Ala Ser Glu Asp

330 335 340acc cca gtg gtg tcc ttc aac taagcccgaa gttttttaac cgc 1167Thr Pro Val Val Ser Phe Asn

345<210>662<211>348<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>662Val Thr Ile Ala Pro Glu Gly Arg Arg Leu Leu Arg Val Glu Ala Arg 151015 Asn Ser Glu Thr Pro Ile Glu Thr Lys Pro Arg Trp Ile Arg Asn Gln

20 25 30Val Lys Asn Gly Pro Glu Tyr Gln Asp Met Lys Glu Arg Val Ala Gly

35 40 45Ala Ser Leu His Thr Val Cys Gln Glu Ala Gly Cys Pro Asn Ile His

50 55 60Glu Cys Trp Glu Ser Arg Glu Ala Thr Phe Leu Ile Gly Gly Ala Asn 65 70 75 80Cys Ser Arg Arg Cys Asp Phe Cys Met Ile Asn Ser Ala Arg Pro Glu

85 90 95Pro Leu Asp Arg Gly Glu Pro Leu Arg Val Ala Glu Ser Val Arg Glu

100 105 110Met Gln Leu Asn Tyr Ser Thr Ile Thr Gly Val Thr Arg Asp Asp Leu

115 120 125Asp Asp Glu Gly Ala Trp Leu Tyr Ser Glu Val Val Arg Lys Ile His

130 135 140Glu Leu Asn Pro His Thr Gly Val Glu Asn Leu Val Pro Asp Phe Ser145 150 155 160Gly Lys Lys Asp Leu Leu Gln Glu Val Phe Glu Ser Arg Pro Glu Val

165 170 175Phe Ala His Asn Val Glu Thr Val Pro Arg Ile Phe Lys Arg Ile Arg

180 185 190Pro Ala Phe Arg Tyr Glu Arg Ser Leu Asp Val Ile Arg Gln Ala Arg

195 200 205Asp Phe Gly Leu Val Thr Lys Ser Asn Leu Ile Leu Gly Met Gly Glu

210 215 220Thr Lys Glu Glu Ile Thr Glu Ala Leu Gln Asp Leu His Asp Ala Gly225 230 235 240Cys Asp Ile Ile Thr Ile Thr Gln Tyr Leu Arg Pro Gly Pro Leu Phe

245 250 255His Pro Ile Glu Arg Trp Val Lys Pro Glu Glu Phe Leu Glu His Ala

260 265 270Asp Ala Ala Lys Glu Met Gly Phe Ala Ala Val Met Ser Gly Pro Leu

275 280 285Val Arg Ser Ser Tyr Arg Ala Gly Arg Leu Tyr Ala Gln Ala Met Glu

290 295 300Phe Arg Gly Glu Glu Ile Pro Ala His Leu Ala His Leu Lys Asp Thr305 310 315 320Ser Gly Gly Ser Thr Ala Gln Glu Ala Ser Thr Leu Leu Glu Arg Tyr

325 330 335Gly Ala Ser Glu Asp Thr Pro Val Val Ser Phe Asn

340345<210>663<211>876<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (853)<223>RXA01746<400>663aaaccgccac tcccctttca ctggggagtg gcggttttgt cgtttcatgc atgcagtgtg 60tgacttatca accttgttag ggctagggtg gatatctatc atg act gca cca aga 115

Met Thr Ala Pro Arg

1 5gat cct ttt ttc ccc gca gat ctt tct atc cgc gcg tct gca gag ccc 163Asp Pro Phe Phe Pro Ala Asp Leu Ser Ile Arg Ala Ser Ala Glu Pro

10 15 20att gaa att cag cgg ttg ggt ttg atc gat tat caa gag gcc tgg gat 211Ile Glu Ile Gln Arg Leu Gly Leu Ile Asp Tyr Gln Glu Ala Trp Asp

25 30 35tat caa gca gag ctt gct acc cgt agg gct aat gat gaa atc cct gat 259Tyr Gln Ala Glu Leu Ala Thr Arg Arg Ala Asn Asp Glu Ile Pro Asp

40 45 50cag ctg ctt att ttg gag cac ccg tcg gtg tat acc gcaggt aag cgc 307Gln Leu Leu Ile Leu Glu His Pro Ser Val Tyr Thr Ala Gly Lys Arg

55 60 65acc cag ccg gaa gat ctt ccc acc aac gga ctg ccg gtg atc aat gct 355Thr Gln Pro Glu Asp Leu Pro Thr Asn Gly Leu Pro Val Ile Asn Ala 70 75 80 85gat cgt ggt ggt cgc atc acg tgg cat ggt cct ggc caa ttg gtg atc 403Asp Arg Gly Gly Arg Ile Thr Trp His Gly Pro Gly Gln Leu Val Ile

90 95 100tat ccg atc atc aaa tta gcc gat ccg atc gat gtg gtt gat tac gta 451Tyr Pro Ile Ile Lys Leu Ala Asp Pro Ile Asp Val Val Asp Tyr Val

105 110 115aga cgc ctc gag gaa gcg ctc atc caa gtt gtc ggc gat atg ggt gtt 499Arg Arg Leu Glu Glu Ala Leu Ile Gln Val ValGly Asp Met Gly Val

120 125 130gcc ggc gct ggg cgc att gat ggg cgt tcg ggt gtg tgg gtg cca gct 547Ala Gly Ala Gly Arg Ile Asp Gly Arg Ser Gly Val Trp Val Pro Ala

135 140 145cat gat ggt tgg gtg gac agc aag gtt gcg gcc atc ggc att cga ata 595His Asp Gly Trp Val Asp Ser Lys Val Ala Ala Ile Gly Ile Arg Ile150 155 160 165act cgt ggt gtt gca atg cac ggt gtg gcc atc aac tgc aac aac acg 643Thr Arg Gly Val Ala Met His Gly Val Ala Ile Asn Cys Asn Asn Thr

170 175 180ttg gat ttc tat gag cac atc att ccg tgt ggc att gct gat gca ggc 691Leu Asp Phe Tyr Glu His Ile Ile Pro Cys Gly Ile Ala Asp Ala Gly

185 190 195ttg agc aca ctc tcg agg gaa ctg aaa agg gac gtt tca gtt gag gaa 739Leu Ser Thr Leu Ser Arg Glu Leu Lys Arg Asp Val Ser Val Glu Glu

200 205 210tta gtc gag cca tcg atc cgc gca ttg gat gat gct ttg gct ggt cgg 787Leu Val Glu Pro Ser Ile Arg Ala Leu Asp Asp Ala Leu Ala Gly Arg

215 220 225ctg gtt gtt tct gat cat tct ttc ggc agc gcg ccc gac cca act aag 835Leu Val Val Ser Asp His Ser Phe Gly Ser Ala Pro Asp Pro Thr Lys230 235 240 245aat ctc cct aaa cgg ggg tagtacgagg aattttgtcg gtg 876Asn Leu Pro Lys Arg Gly

250<210>664<211>251<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>664Met Thr Ala Pro Arg Asp Pro Phe Phe Pro Ala Asp Leu Ser Ile Arg 151015 Ala Ser Ala Glu Pro Ile Glu Ile Gln Arg Leu Gly Leu Ile Asp Tyr

20 25 30Gln Glu Ala Trp Asp Tyr Gln Ala Glu Leu Ala Thr Arg Arg Ala Asn

35 40 45Asp Glu Ile Pro Asp Gln Leu Leu Ile Leu Glu His Pro Ser Val Tyr

50 55 60Thr Ala Gly Lys Arg Thr Gln Pro Glu Asp Leu Pro Thr Asn Gly Leu 65 70 75 80Pro Val Ile Asn Ala Asp Arg Gly Gly Arg Ile Thr Trp His Gly Pro

85 90 95Gly Gln Leu Val Ile Tyr Pro Ile Ile Lys Leu Ala Asp Pro Ile Asp

100 105 110Val Val Asp Tyr Val Arg Arg Leu Glu Glu Ala Leu Ile Gln Val Val

115 120 125Gly Asp Met Gly Val Ala Gly Ala Gly Arg Ile Asp Gly Arg Ser Gly

130 135 140Val Trp Val Pro Ala His Asp Gly Trp Val Asp SerLys Val Ala Ala145 150 155 160Ile Gly Ile Arg Ile Thr Arg Gly Val Ala Met His Gly Val Ala Ile

165 170 175Asn Cys Asn Asn Thr Leu Asp Phe Tyr Glu His Ile Ile Pro Cys Gly

180 185 190Ile Ala Asp Ala Gly Leu Ser Thr Leu Ser Arg Glu Leu Lys Arg Asp

195 200 205Val Ser Val Glu Glu Leu Val Glu Pro Ser Ile Arg Ala Leu Asp Asp

210 215 220Ala Leu Ala Gly Arg Leu Val Val Ser Asp His Ser Phe Gly Ser Ala225 230 235 240Pro Asp Pro Thr Lys Asn Leu Pro Lys Arg Gly

245250<210>665<211>1179<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1156)<223>RXA02106<400>665ggtcgccgct tttcgacgcc cgcctgcggc gggatgactg tgatggaggg gcgcgtcgac 60aagcaaaatc tctttagcaa attcggttac tgtggggcgc atg aat aac cat ttt 115

Met Asn Asn His Phe

1 5gag ctc aaa gta cct ggt gga aag ctt gtc gtc gtt gat gtg acc acc 163Glu Leu Lys Val Pro Gly Gly Lys Leu Val Val Val Asp Val Thr Thr

10 15 20gat ctg gat tcc att gct gac gtg aag att tcc ggc gat ttc ttc ctc 211Asp Leu Asp Ser Ile Ala Asp Val Lys Ile Ser Gly Asp Phe Phe Leu

25 30 35gaa ccc gat gag gca ttc ttc gcc ctt ggc cgg gcg ctg cag ggg gcg 259Glu Pro Asp Glu Ala Phe Phe Ala Leu Gly Arg Ala Leu GlnGly Ala

40 45 50tcg gtg ggt gat aac act gat cgt ttg cag gca aag ttg gat gca gcg 307Ser Val Gly Asp Asn Thr Asp Arg Leu Gln Ala Lys Leu Asp Ala Ala

55 60 65ttg gcg gaa tat gat gac gtt gag cta cac ggc ttt agc act gcg gat 355Leu Ala Glu Tyr Asp Asp Val Glu Leu His Gly Phe Ser Thr Ala Asp 70 75 80 85att gct tta gct gtg cgt cgg gca gtc acc ggc gcg caa gat ttc acc 403Ile Ala Leu Ala Val Arg Arg Ala Val Thr Gly Ala Gln Asp Phe Thr

90 95 100gat tat gaa tgg gaa atc ctg cac cca ggg gtg ctt cct acc cca ctt 451Asp Tyr Glu Trp Glu Ile Leu His Pro Gly Val Leu Pro Thr Pro Leu

105 110 115aac gtt gcg ttg gat gag ctc ctt ttg gac caa gtt gcc agt ggt cag 499Asn Val Ala Leu Asp Glu Leu Leu Leu Asp Gln Val Ala Ser Gly Gln

120 125 130cgt ggc ccg acg atg cgc att tgg gat tgg gat gat cgc gcc aca gtg 547Arg Gly Pro Thr Met Arg Ile Trp Asp Trp Asp Asp Arg Ala Thr Val

135 140 145atc ggt agt ttc cag tca tat gtc aat gaa atc aac caa gaa ggc gtt 595Ile Gly Ser Phe Gln Ser Tyr Val Asn Glu Ile Asn Gln Glu Gly Val150 155 160 165aat gaa cat ggt gtg acc gtg gta cga cgc atg tct ggt ggc ggt gca 643Asn Glu His Gly Val Thr Val Val Arg Arg Met Ser Gly Gly Gly Ala

170 175 180atg ttt atg gag ggc ggc aac tgc atc acc tat tcc ctg tat gca ccg 691Met Phe Met Glu Gly Gly Asn Cys Ile Thr Tyr Ser Leu Tyr Ala Pro

185 190 195gaa tct ctc gtt gct ggt ttg agc tat gag cag tcc tat gaa tat ttg 739Glu Ser Leu Val Ala Gly Leu Ser Tyr Glu Gln Ser Tyr Glu Tyr Leu

200 205 210

gat cgt tgg gtg att gct gcg ctg aag aca cac gat gtt gac gct tgg 787Asp Arg Trp Val Ile Ala Ala Leu Lys Thr His Asp Val Asp Ala Trp

215 220 225tac gtg cct atc aat gac atc acc tcc acc ggc gga aaa atc ggt ggc 835Tyr Val Pro Ile Asn Asp Ile Thr Ser Thr Gly Gly Lys Ile Gly Gly230 235 240 245gct gca cag aaa cgt cgc agt ggc gca gtc ctc cac cac gtg acc atg 883Ala Ala Gln Lys Arg Arg Ser Gly Ala Val Leu His His Val Thr Met

250 255 260tcc tat gac atc gat gcg gac atg atg acc cag gtg ttg cgc att gga 931Ser Tyr Asp Ile Asp Ala Asp Met Met Thr Gln Val Leu Arg Ile Gly

265 270 275aag gtg aag att tcc gac aag ggt ctt cgc agc gca aag aag cgc gtt 979Lys Val Lys Ile Ser Asp Lys Gly Leu Arg Ser Ala Lys Lys Arg Val

280 285 290gat cct ctg cgc cgc caa aca ggt gca tca cgt gag caa atc atc gac 1027Asp Pro Leu Arg Arg Gln Thr Gly Ala Ser Arg Glu Gln Ile Ile Asp

295 300 305acc cta aag tcc aca ttc agt gct agg tac ggc gcg caa gaa gta gag 1075Thr Leu Lys Ser Thr Phe Ser Ala Arg Tyr Gly Ala Gln Glu Val Glu310 315 320 325ctc agc gat gaa gat ttc gcg gca ggc cac gac cta gta aaa acc aaa 1123Leu Ser Asp Glu Asp Phe Ala Ala Gly His Asp Leu Val Lys Thr Lys

330 335 340tac gcc acc gag gag tgg act aag cga gtt caa tagtttctat ggatctgcac 1176Tyr Ala ThrGlu Glu Trp Thr Lys Arg Val Gln

345350 aag 1179<210>666<211>352<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>666Met Asn Asn His Phe Glu Leu Lys Val Pro Gly Gly Lys Leu Val Val 151015 Val Asp Val Thr Thr Asp Leu Asp Ser Ile Ala Asp Val Lys Ile Ser

20 25 30Gly Asp Phe Phe Leu Glu Pro Asp Glu Ala Phe Phe Ala Leu Gly Arg

35 40 45Ala Leu Gln Gly Ala Ser Val Gly Asp Asn Thr Asp Arg Leu Gln Ala

50 55 60Lys Leu Asp Ala Ala Leu Ala Glu Tyr Asp Asp Val Glu Leu His Gly 65 70 75 80Phe Ser Thr Ala Asp Ile Ala Leu Ala Val Arg Arg Ala Val Thr Gly

85 90 95Ala Gln Asp Phe Thr Asp Tyr Glu Trp Glu Ile Leu His Pro Gly Val

100 105 110Leu Pro Thr Pro Leu Asn Val Ala Leu Asp Glu Leu Leu Leu Asp Gln

115 120 125Val Ala Ser Gly Gln Arg Gly Pro Thr Met Arg Ile Trp Asp Trp Asp

130 135 140Asp Arg Ala Thr Val Ile Gly Ser Phe Gln Ser Tyr Val Asn Glu Ile145 150 155 160Asn Gln Glu Gly Val Asn Glu His Gly Val Thr Val Val Arg Arg Met

165 170 175Ser Gly Gly Gly Ala Met Phe Met Glu Gly Gly Asn Cys Ile Thr Tyr

180 185 190Ser Leu Tyr Ala Pro Glu Ser Leu Val Ala Gly Leu Ser Tyr Glu Gln

195 200205Ser Tyr Glu Tyr Leu Asp Arg Trp Val Ile Ala Ala Leu Lys Thr His

210 215 220Asp Val Asp Ala Trp Tyr Val Pro Ile Asn Asp Ile Thr Ser Thr Gly225 230 235 240Gly Lys Ile Gly Gly Ala Ala Gln Lys Arg Arg Ser Gly Ala Val Leu

245 250 255His His Val Thr Met Ser Tyr Asp Ile Asp Ala Asp Met Met Thr Gln

260 265 270Val Leu Arg Ile Gly Lys Val Lys Ile Ser Asp Lys Gly Leu Arg Ser

275 280 285Ala Lys Lys Arg Val Asp Pro Leu Arg Arg Gln Thr Gly Ala Ser Arg

290 295 300Glu Gln Ile Ile Asp Thr Leu Lys Ser Thr Phe Ser Ala Arg Tyr Gly305 310 315 320Ala Gln Glu Val Glu Leu Ser Asp Glu Asp Phe Ala Ala Gly His Asp

325 330 335Leu Val Lys Thr Lys Tyr Ala Thr Glu Glu Trp Thr Lys Arg Val Gln

340345350<210>667<211>403<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (403)<223>RXS01183<400>667cttgatatga cccgaacacc acacatcaca aattgaatcg gtatcctttg gggtattagt 60ttccgtttta acgacacgac ttgcgaggag tcttaaaata atg gcg ttc tcc gta 115

Met Ala Phe Ser Val

1 5gag atg ccc gag ctg ggc gaa tca gta acc gaa ggc acg atc acc cag 163Glu Met Pro Glu Leu Gly Glu Ser Val Thr Glu Gly Thr Ile Thr Gln

1015 20tgg ttg aag tct gtt ggt gac act gtt gag gta gat gag ccg ttg ctc 211Trp Leu Lys Ser Val Gly Asp Thr Val Glu Val Asp Glu Pro Leu Leu

25 30 35gag gtc tca act gac aag gtc gac acc gag att ccc tct cct gtc gcc 259Glu Val Ser Thr Asp Lys Val Asp Thr Glu Ile Pro Ser Pro Val Ala

40 45 50ggt gtc atc cta gag att aag gct gaa gag gat gac acc gtc gac gtc 307Gly Val Ile Leu Glu Ile Lys Ala Glu Glu Asp Asp Thr Val Asp Val

55 60 65ggc ggt gtc att gca ata atc ggc gat gct gat gag act cct gcc aac 355Gly Gly Val Ile Ala Ile Ile Gly Asp Ala Asp Glu Thr Pro Ala Asn 70 75 80 85gaa gct cct gcc gac gag gca cca gct cct gcc gaa gag gaa gaa cca 403Glu Ala Pro Ala Asp Glu Ala Pro Ala Pro Ala Glu Glu Glu Glu Pro

9095100<210>668<211>101<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>668Met Ala Phe Ser Val Glu Met Pro Glu Leu Gly Glu Ser Val Thr Glu 151015 Gly Thr Ile Thr Gln Trp Leu Lys Ser Val Gly Asp Thr Val Glu Val

20 25 30Asp Glu Pro Leu Leu Glu Val Ser Thr Asp Lys Val Asp Thr Glu Ile

35 40 45Pro Ser Pro Val Ala Gly Val Ile Leu Glu Ile Lys Ala Glu Glu Asp

50 55 60Asp Thr Val Asp Val Gly Gly Val Ile Ala Ile Ile Gly Asp Ala Asp65 70 75 80Glu Thr Pro Ala Asn Glu Ala Pro Ala Asp Glu Ala Pro Ala Pro Ala

85 90 95Glu Glu Glu Glu Pro

100<210>669<211>1305<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1282)<223>RXS01260<400>669ctaaacgtgg gctgcattcc ttccaaagtc tctgatcaaa aacgctgaag ttgcccatac 60ctttacccat gagaagaaga ccttcggcat caatggcgaa gtg acc ttc aac tat 115

Val Thr Phe Asn Tyr

1 5gag gat gct cac aag cgt tcc cgt ggc gtt tcc gac aag atc gtt gga 163Glu Asp Ala His Lys Arg Ser Arg Gly Val Ser Asp Lys Ile Val Gly

10 15 20ggc gtt cat tac ttg atg aag aag aac aag atc atc gaa att cat ggt 211Gly Val His Tyr Leu Met Lys Lys Asn Lys Ile Ile Glu Ile His Gly

25 30 35ctt gga aac ttc aag gat gct aag act ctt gag gtc acc gac ggt aag 259Leu Gly Asn Phe Lys Asp Ala Lys Thr Leu Glu Val Thr Asp Gly Lys

40 45 50gat gct ggc aag acc atc acc ttt gat gac tgc atc atc gca acc ggt 307Asp Ala Gly Lys Thr Ile Thr Phe Asp Asp Cys Ile Ile Ala Thr Gly

55 60 65tcg gta gtc aac acc ctc cgt ggc gtt gac ttc tca gag aac gtt gtg 355Ser Val Val Asn Thr Leu Arg Gly Val Asp Phe Ser Glu Asn Val Val70 75 80 85tct ttt gaa gag cag att ctt aac cct gtt gcg cca aag aag atg gtc 403Ser Phe Glu Glu Gln Ile Leu Asn Pro Val Ala Pro Lys Lys Met Val

90 95 100att gtt ggt gca ggc gca att gga atg gaa ttc gcc tac gtt ctt ggt 451Ile Val Gly Ala Gly Ala Ile Gly Met Glu Phe Ala Tyr Val Leu Gly

105 110 115aac tac ggt gta gat gta acc gtc atc gag ttc atg gat cgt gtg ctt 499Asn Tyr Gly Val Asp Val Thr Val Ile Glu Phe Met Asp Arg Val Leu

120 125 130cca aat gaa gat gct gaa gtc tcc aag gtt att gca aag gcc tac aag 547Pro Asn Glu Asp Ala Glu Val Ser Lys Val Ile Ala Lys Ala Tyr Lys

135 140 145aag atg ggc gtt aag ctt ctt cct ggc cat gca acc act gct gtt cgg 595Lys Met Gly Val Lys Leu Leu Pro Gly His Ala Thr Thr Ala Val Arg150 155 160 165gac aac ggt gac ttt gtc gag gtt gat tac cag aag aag ggc tct gac 643Asp Asn Gly Asp Phe Val Glu Val Asp Tyr Gln Lys Lys Gly Ser Asp

170 175 180aag aca gag act ctt act gtt gat cga gtc atg gtt tcc gtt ggt ttc 691Lys Thr Glu Thr Leu Thr Val Asp Arg Val Met Val Ser Val Gly Phe

185 190 195cgt cca cgc gtt gag gga ttt ggt ctt gaa aac act ggc gtt aag ctc 739Arg Pro Arg Val Glu Gly Phe Gly Leu Glu Asn Thr Gly Val Lys Leu

200 205 210acc gag cgt ggc gca atc gag atc gat gat tac atg cgt acc aac gtc 787Thr Glu Arg Gly Ala Ile Glu Ile Asp Asp Tyr Met Arg Thr Asn Val

215 220 225gat ggc att tac gcc atc ggt gac gtg acc gcc aag ctt cag ctt gct 835Asp Gly Ile Tyr Ala Ile Gly Asp Val Thr Ala Lys Leu Gln Leu Ala230 235 240 245cac gtc gca gaa gca cag ggc att gtt gcc gca gag act att gct ggt 883His Val Ala Glu Ala Gln Gly Ile Val Ala Ala Glu Thr Ile Ala Gly

250 255 260gca gaa act cag act ctt ggt gat tac atg atg atg cca cgt gca acc 931Ala Glu Thr Gln Thr Leu Gly Asp Tyr Met Met Met Pro Arg Ala Thr

265 270 275ttc tgc aac cca cag gtt tct tcc ttt ggt tac acc gaa gag cag gcc 979Phe Cys Asn Pro Gln Val Ser Ser Phe Gly Tyr Thr Glu Glu Gln Ala

280 285 290aag gag aag tgg cca gat cgt gag atc aag gtt gct tcc ttc cca ttc 1027Lys Glu Lys Trp Pro Asp Arg Glu Ile Lys Val Ala Ser Phe Pro Phe

295 300 305tct gca aac ggt aaa gca gtt ggc ctg gca gaa act gat ggt ttc gca 1075Ser Ala Asn Gly Lys Ala Val Gly Leu Ala Glu Thr Asp Gly Phe Ala310 315 320 325aag atc gtt gct gat gca gaa ttc ggt gag ctg ctc ggt gca cac ctg 1123Lys Ile Val Ala Asp Ala Glu Phe Gly Glu Leu Leu Gly Ala His Leu

330 335 340gtt gga gca aat gca tca gag ctc atc aat gaa ttg gtg ctt gct cag 1171Val Gly Ala Asn Ala Ser Glu Leu Ile Asn Glu Leu Val Leu Ala Gln

345 350 355aac tgg gat ctc acc act gaa gag atc tct cgt agc gtc cat att cac 1219Asn Trp Asp Leu Thr Thr Glu Glu Ile Ser Arg Ser Val His Ile His

360 365 370cca acg cta tct gag gca gtt aag gaa gct gca cac ggt atc tct gga 1267Pro Thr Leu Ser Glu Ala Val Lys Glu Ala Ala His Gly Ile Ser Gly

375380385 cac atg atc aac ttc tagaatccac ctcgttggcc ctg 1305His Met Ile Asn Phe390<210>670<211>394<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>670Val Thr Phe Asn Tyr Glu Asp Ala His Lys Arg Ser Arg Gly Val Ser 151015 Asp Lys Ile Val Gly Gly Val His Tyr Leu Met Lys Lys Asn Lys Ile

20 25 30Ile Glu Ile His Gly Leu Gly Asn Phe Lys Asp Ala Lys Thr Leu Glu

35 40 45Val Thr Asp Gly Lys Asp Ala Gly Lys Thr Ile Thr Phe Asp Asp Cys

50 55 60Ile Ile Ala Thr Gly Ser Val Val Asn Thr Leu Arg Gly Val Asp Phe 65 70 75 80Ser Glu Asn Val Val Ser Phe Glu Glu Gln Ile Leu Asn Pro Val Ala

85 90 95Pro Lys Lys Met Val Ile Val Gly Ala Gly Ala Ile Gly Met Glu Phe

100 105 110Ala Tyr Val Leu Gly Asn Tyr Gly Val Asp Val Thr Val Ile Glu Phe

115 120 125Met Asp Arg Val Leu Pro Asn Glu Asp Ala Glu Val Ser Lys Val Ile

130 135 140Ala Lys Ala Tyr Lys Lys Met Gly Val Lys Leu Leu Pro Gly His Ala145 150 155 160Thr Thr Ala Val Arg Asp Asn Gly Asp Phe Val Glu Val Asp Tyr Gln

165 170 175Lys Lys Gly Ser Asp Lys Thr Glu Thr Leu Thr Val Asp Arg Val Met

180 185 190Val Ser Val Gly Phe Arg Pro Arg Val Glu Gly Phe Gly Leu Glu Asn

195 200 205Thr Gly Val Lys Leu Thr Glu Arg Gly Ala Ile Glu Ile Asp Asp Tyr

210 215 220Met Arg Thr Asn Val Asp Gly Ile Tyr Ala Ile Gly Asp Val Thr Ala225 230 235 240Lys Leu Gln Leu Ala His Val Ala Glu Ala Gln Gly Ile Val Ala Ala

245 250 255Glu Thr Ile Ala Gly Ala Glu Thr Gln Thr Leu Gly Asp Tyr Met Met

260 265 270Met Pro Arg Ala Thr Phe Cys Asn Pro Gln Val Ser Ser Phe Gly Tyr

275 280 285Thr Glu Glu Gln Ala Lys Glu Lys Trp Pro Asp Arg Glu Ile Lys Val

290 295 300Ala Ser Phe Pro Phe Ser Ala Asn Gly Lys Ala Val Gly Leu Ala Glu305 310 315 320Thr Asp Gly Phe Ala Lys Ile Val Ala Asp Ala Glu Phe Gly Glu Leu

325 330 335Leu Gly Ala His Leu Val Gly Ala Asn Ala Ser Glu Leu Ile Asn Glu

340 345 350Leu Val Leu Ala Gln Asn Trp Asp Leu Thr Thr Glu Glu Ile Ser Arg

355 360 365Ser Val His Ile His Pro Thr Leu Ser Glu Ala Val Lys Glu Ala Ala

370375380 His Gly Ile Ser Gly His Met Ile Asn Phe 385390<210>671<211>294<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) · (271)<223>RXS01261<400>671gtgggtgttt ttcattttct tccactctaa aattaagtat ggaaaaccaa ccgcacccgg 60atgcacgaca atgacccact aaacacgtat ccttgaatgc gtg act gaa cat tat 115

Val Thr Glu His Tyr

1 5gac gta gta gta ctc gga gcc ggc ccc ggt ggc tat gtc tcc gcc atc 163Asp Val Val Val Leu Gly Ala Gly Pro Gly Gly Tyr Val Ser Ala Ile

10 15 20cgt gca gcg cag ctt ggc aag aag gttgct gta att gag aag cag tac 211Arg Ala Ala Gln Leu Gly Lys Lys Val Ala Val Ile Glu Lys Gln Tyr

25 30 35tgg ggt ggt gtt tgc cta aac gtg ggc tgc att cct tcc aaa gtc tct 259Trp Gly Gly Val Cys Leu Asn Val Gly Cys Ile Pro Ser Lys Val Ser

40 45 50gat caa aaa cgc tgaagttgcc cataccttta ccc 294Asp Gln Lys Arg

55<210>672<211>57<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>672Val Thr Glu His Tyr Asp Val Val Val Leu Gly Ala Gly Pro Gly Gly 151015 Tyr Val Ser Ala Ile Arg Ala Ala Gln Leu Gly Lys Lys Val Ala Val

20 25 30Ile Glu Lys Gln Tyr Trp Gly Gly Val Cys Leu Asn Val Gly Cys Ile

35 40 45Pro Ser Lys Val Ser Asp Gln Lys Arg

5055<210>673<211>1005<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (982)<223>RXA02717<400>673aggcatgtcc ctaacgaaca tcccagcctc atctcaatgg gcaattagcg acgttttgaa 60gcgtccttca cccggccgag tacctttttc tgtcgagttt atg cca ccc cgc gac 115

Met Pro Pro Arg Asp

1 5gat gca gct gaa gag cgt ctt tac cgc gca gca gag gtc ttc cat gac 163Asp Ala Ala Glu Glu Arg Leu Tyr Arg Ala Ala Glu Val Phe His Asp

10 15 20ctc ggt gca tcg ttt gtc tcc gtg act tat ggt gct ggc gga tca acc 211Leu Gly Ala Ser Phe Val Ser Val Thr Tyr Gly Ala Gly Gly Ser Thr

25 30 35cgt gag aga acc tca cgt att gct cga cga tta gcg aaa caa ccg ttg 259Arg Glu Arg Thr Ser Arg Ile Ala Arg Arg Leu Ala Lys Gln Pro Leu

40 45 50acc act ctg gtg cac ctg acc ctg gtt aac cac act cgc gaa gag atg 307Thr Thr Leu Val His Leu Thr Leu Val Asn His Thr Arg Glu Glu Met

55 60 65aag gca att ctt cgg gaa tac cta gag ctg gga tta aca aac ctg ttg 355Lys Ala Ile Leu Arg Glu Tyr Leu Glu Leu Gly Leu Thr Asn Leu Leu 70 75 80 85gcg ctt cga gga gat ccg cct gga gac cca tta ggc gat tgg gtg agc 403Ala Leu Arg Gly Asp Pro Pro Gly Asp Pro Leu Gly Asp Trp Val Ser

90 95 100acc gat gga gga ctg aac tat gcc tct gag ctc atc gat ctt att aag 451Thr Asp Gly Gly Leu Asn Tyr Ala Ser Glu Leu Ile Asp Leu Ile Lys

105 110 115tcc act cct gag ttc cgg gaa ttc gac ctc ggt atc gcc tcc ttc ccc 499Ser Thr Pro Glu Phe Arg Glu Phe Asp Leu Gly Ile Ala Ser Phe Pro

120 125 130gaa ggg cat ttc cgg gcg aaa act cta gaa gaa gac acc aaa tac act 547Glu Gly His Phe Arg Ala Lys Thr Leu Glu Glu Asp Thr Lys Tyr Thr

135 140 145ctg gcg aag ctg cgt gga ggg gca gag tac tcc atc acg cag atg ttc 595Leu Ala Lys Leu Arg Gly Gly Ala Glu Tyr Ser Ile Thr Gln Met Phe150 155 160 165ttt gat gtg gaa gac tac ctg cga ctt cgt gat cgc ctt gtc gct gca 643Phe Asp Val Glu Asp Tyr Leu Arg Leu Arg Asp Arg Leu Val Ala Ala

170 175 180gac ccc att cat ggt gcg aag cca atc att cct ggcatc atg ccc att 691Asp Pro Ile His Gly Ala Lys Pro Ile Ile Pro Gly Ile Met Pro Ile

185 190 195acg agc ctg cgg tct gtg cgt cga cag gtc gaa ctc tct ggt gct caa 739Thr Ser Leu Arg Ser Val Arg Arg Gln Val Glu Leu Ser Gly Ala Gln

200 205 210ttg ccg agc caa cta gaa gaa tca ctt gtt cga gct gca aac ggc aat 787Leu Pro Ser Gln Leu Glu Glu Ser Leu Val Arg Ala Ala Asn Gly Asn

215 220 225gaa gaa gcg aac aaa gac gag atc cgc aag gtg ggc att gaa tat tcc 835Glu Glu Ala Asn Lys Asp Glu Ile Arg Lys Val Gly Ile Glu Tyr Ser230 235 240 245acc aat atg gca gag cga ctc att gcc gaa ggt gcg gaa gat ctg cac 883Thr Asn Met Ala Glu Arg Leu Ile Ala Glu Gly Ala Glu Asp Leu His

250 255 260ttc atg acg ctt aac ttc acc cgt gca acc caa gaa gtg ttg tac aac 931Phe Met Thr Leu Asn Phe Thr Arg Ala Thr Gln Glu Val Leu Tyr Asn

265 270 275ctt ggc atg gcg cct gct tgg gga gca gag cac ggc caa gac gcg gtg 979Leu Gly Met Ala Pro Ala Trp Gly Ala Glu His Gly Gln Asp Ala Val

280285290 cgt taagccctct taggaatcat gaa 1005Arg<210>674<211>294<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>674Met Pro Pro Arg Asp Asp Ala Ala Glu Glu Arg Leu Tyr Arg Ala Ala 151015 Glu Val Phe His Asp Leu Gly Ala Ser Phe Val Ser Val Thr Tyr Gly

20 25 30Ala Gly Gly Ser Thr Arg Glu Arg Thr Ser Arg Ile Ala Arg Arg Leu

35 40 45Ala Lys Gln Pro Leu Thr Thr Leu Val His Leu Thr Leu Val Asn His

50 55 60Thr Arg Glu Glu Met Lys Ala Ile Leu Arg Glu Tyr Leu Glu Leu Gly 65 70 75 80Leu Thr Asn Leu Leu Ala Leu Arg Gly Asp Pro Pro Gly Asp Pro Leu

85 90 95Gly Asp Trp Val Ser Thr Asp Gly Gly Leu Asn Tyr Ala Ser Glu Leu

100 105 110Ile Asp Leu Ile Lys Ser Thr Pro Glu Phe Arg Glu Phe Asp Leu Gly

115 120 125Ile Ala Ser Phe Pro Glu Gly His Phe Arg Ala Lys Thr Leu Glu Glu

130 135 140Asp Thr Lys Tyr Thr Leu Ala Lys Leu Arg Gly Gly Ala Glu Tyr Ser145 150 155 160Ile Thr Gln Met Phe Phe Asp Val Glu Asp Tyr Leu Arg Leu Arg Asp

165 170 175Arg Leu Val Ala Ala Asp Pro Ile His Gly Ala Lys Pro Ile Ile Pro

180 185 190Gly Ile Met Pro Ile Thr Ser Leu Arg Ser Val Arg Arg Gln Val Glu

195 200 205Leu Ser Gly Ala Gln Leu Pro Ser Gln Leu Glu Glu Ser Leu Val Arg

210 215 220Ala Ala Asn Gly Asn Glu Glu Ala Asn Lys Asp Glu Ile Arg Lys Val225 230 235 240Gly Ile Glu Tyr Ser Thr Asn Met Ala Glu Arg Leu Ile Ala Glu Gly

245 250 255Ala Glu Asp Leu His Phe Met Thr Leu Asn Phe Thr Arg Ala Thr Gln

260 265 270Glu Val Leu Tyr Asn Leu Gly Met Ala Pro Ala Trp Gly Ala Glu His

275 280 285Gly Gln Asp Ala Val Arg

290<210>675<211>601<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (601)<223>RXN02027<400>675tcacgtgctc atcgataggc aaactcatgg aaccaagagt acctgccccc gcaaccccaa 60tcgtcgtacc cctccgaaaa taacggttat ccttagattt atg agc caa act aag 115

Met Ser Gln Thr Lys

1 5cag gaa ctg cgc acg aag ctt cgg gaa gcg cgc acc aat atg gat gag 163Gln Glu Leu Arg Thr Lys Leu Arg Glu Ala Arg Thr Asn Met Asp Glu

10 15 20gct tct cgc acg cga gaa aac gca gcc atc att gcc aac gtt tct tat 211Ala Ser Arg Thr Arg Glu Asn Ala Ala Ile Ile Ala Asn Val Ser Tyr

25 30 35tac atc cgc tca aag cag cca aaa agg att gcc gct tac gtg ccg gtg 259Tyr Ile Arg Ser Lys Gln Pro Lys Arg Ile Ala Ala Tyr Val Pro Val

40 45 50cgt acc gaa cct ggt ggg cga ttg ctt ctt gac gcc ctc cac gcc gaa 307Arg Thr Glu Pro Gly Gly Arg Leu Leu Leu Asp Ala Leu His Ala Glu

55 60 65act tcc gcg ctt att ttg cca gtc tcc ctc gag gat cga cgc ctc gac 355Thr Ser Ala Leu Ile Leu Pro Val Ser Leu Glu Asp Arg Arg Leu Asp 70 75 80 85tgg gct ctt tat gaa ggc cca acc agc ctt gtt cct ggc gca ttt ggc 403Trp Ala Leu Tyr Glu Gly Pro Thr Ser Leu Val Pro Gly Ala Phe Gly

90 95 100atc cag gaa ccc ggt ggc act cgcctt gga cct gaa gct ctc aac ttc 451Ile Gln Glu Pro Gly Gly Thr Arg Leu Gly Pro Glu Ala Leu Asn Phe

105 110 115tgc gac ctt gtc atc gcc ccc gca ctg gca tgc acc ccc agt gga atc 499Cys Asp Leu Val Ile Ala Pro Ala Leu Ala Cys Thr Pro Ser Gly Ile

120 125 130agg cta ggt aaa ggt ggc ggt ttc tac gac cgc gct cta gcc acc gga 547Arg Leu Gly Lys Gly Gly Gly Phe Tyr Asp Arg Ala Leu Ala Thr Gly

135140145 gtc aag gct gac gtg att act ttg ctc ttc aac gga gaa atc cgc gac 595Val Lys Ala Asp Val Ile Thr Leu Leu Phe Asn Gly Glu Ile Arg Asp 150155160165 gat atc 601Asp Ile<210>676<211>167<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>676Met Ser Gln Thr Lys Gln Glu Leu Arg Thr Lys Leu Arg Glu Ala Arg 151015 Thr Asn Met Asp Glu Ala Ser Arg Thr Arg Glu Asn Ala Ala Ile Ile

20 25 30Ala Asn Val Ser Tyr Tyr Ile Arg Ser Lys Gln Pro Lys Arg Ile Ala

35 40 45Ala Tyr Val Pro Val Arg Thr Glu Pro Gly Gly Arg Leu Leu Leu Asp

50 55 60Ala Leu His Ala Glu Thr Ser Ala Leu Ile Leu Pro Val Ser Leu Glu 65 70 75 80Asp Arg Arg Leu Asp Trp Ala Leu Tyr Glu Gly Pro Thr Ser Leu Val

85 90 95Pro Gly Ala Phe Gly Ile Gln Glu Pro Gly Gly Thr Arg Leu Gly Pro

100 105 110Glu Ala Leu Asn Phe Cys Asp Leu Val Ile Ala Pro Ala Leu Ala Cys

115 120 125Thr Pro Ser Gly Ile Arg Leu Gly Lys Gly Gly Gly Phe Tyr Asp Arg

130 135 140Ala Leu Ala Thr Gly Val Lys Ala Asp Val Ile Thr Leu Leu Phe Asn145 150 155 160Gly Glu Ile Arg Asp Asp Ile

165<210>677<211>595<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (595)<223>FRXA02027<400>677tcacgtgctc atcgataggc aaactcatgg aaccaagagt acctgccccc gcaaccccaa 60tcgtcgtacc cctccgaaaa taacggttat ccttagattt atg agc caa act aag 115

Met Ser Gln Thr Lys

1 5cag gaa ctg cgc acg aag ctt cgg gaa gcg cgc acc aat atg gat gag 163Gln Glu Leu Arg Thr Lys Leu Arg Glu Ala Arg Thr Asn Met Asp Glu

10 15 20gct tct cgc acg cga gaa aac gca gcc atc att gcc aac gtt tct tat 211Ala Ser Arg Thr Arg Glu Asn Ala Ala Ile Ile Ala Asn Val Ser Tyr

25 30 35tac atc cgc tca aag cag cca aaa agg att gcc gct tac gtg ccg gtg 259Tyr Ile Arg Ser Lys Gln Pro Lys Arg Ile Ala Ala Tyr Val Pro Val

40 45 50cgt acc gaa cct ggt ggg cga ttg ctt ctt gac gcc ctc cac gcc gaa 307Arg Thr Glu Pro Gly Gly Arg Leu Leu Leu Asp Ala Leu His Ala Glu

55 60 65act tcc gcg ctt att ttg cca gtc tcc ctc gag gat cga cgc ctc gac 355Thr Ser Ala Leu Ile Leu Pro Val Ser Leu Glu Asp Arg Arg Leu Asp 70 75 80 85tgg gct ctt tat gaa ggc cca acc agc ctt gtt cct ggc gca ttt ggc 403Trp Ala Leu Tyr Glu Gly Pro Thr Ser Leu Val Pro Gly Ala Phe Gly

90 95 100atc cag gaa ccc ggt ggc act cgc ctt gga cct gaa gct ctc aac ttc 451Ile Gln Glu Pro Gly Gly Thr Arg Leu Gly Pro Glu Ala Leu Asn Phe

105 110 115tgc gac ctt gtc atc gcc ccc gca ctg gca tgc acc ccc agt gga atc 499Cys Asp Leu Val Ile Ala Pro Ala Leu Ala Cys Thr Pro Ser Gly Ile

120 125 130agg cta ggt aaa ggt ggc ggt ttc tac gac cgc gct cta gcc acc gga 547Arg Leu Gly Lys Gly Gly Gly Phe Tyr Asp Arg Ala Leu Ala Thr Gly

135140145 gtc aag gct gac gtg att act ttg ctc ttc aac gga gaa atc cgc gac 595Val Lys Ala Asp Val Ile Thr Leu Leu Phe Asn Gly Glu Ile Arg Asp 150155160165<210>678<211>165<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>678Met Ser Gln Thr Lys Gln Glu Leu Arg Thr Lys Leu Arg Glu Ala Arg 151015 Thr Asn Met Asp Glu Ala Ser Arg Thr Arg Glu Asn Ala Ala Ile Ile

20 25 30Ala Asn Val Ser Tyr Tyr Ile Arg Ser Lys Gln Pro Lys Arg Ile Ala

35 40 45Ala Tyr Val Pro Val Arg Thr Glu Pro Gly Gly Arg Leu Leu Leu Asp

50 55 60Ala Leu His Ala Glu Thr Ser Ala Leu Ile Leu Pro Val Ser Leu Glu 65 70 75 80Asp Arg Arg Leu Asp Trp Ala Leu Tyr Glu Gly Pro Thr Ser Leu Val

85 90 95Pro Gly Ala Phe Gly Ile Gln Glu Pro Gly Gly Thr Arg Leu Gly Pro

100 105 110Glu Ala Leu Asn Phe Cys Asp Leu Val Ile Ala Pro Ala Leu Ala Cys

115 120 125Thr Pro Ser Gly Ile Arg Leu Gly Lys Gly Gly Gly Phe Tyr Asp Arg

130 135 140Ala Leu Ala Thr Gly Val Lys Ala Asp Val Ile Thr Leu Leu Phe Asn145 150 155 160Gly Glu Ile Arg Asp

165<210>679<211>579<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (556)<223>RXA00106<400>679tggagctcaa caaggcagcg tacatgtttg agtacagctt cgatgacatc accgtgtccg 60gctacgatcc acacccattg atccgcggca aggtcgccgt atg atc ggt gcg att 115

Met Ile Gly Ala Ile

1 5tgg gca caa ggc cgt gac ggc atc atc ggc gac ggc acc gac atg ccc 163Trp Ala Gln Gly Arg Asp Gly Ile Ile Gly Asp Gly Thr Asp Met Pro

10 15 20tgg cac atc ccg gaa gac ctc aaa cac ttc aag aaa acc acc atg ggc 211Trp His Ile Pro Glu Asp Leu Lys His Phe Lys Lys Thr Thr Met Gly

25 30 35cag ccg gtc atc atg ggt cgt cgc acg tgg gag tct ttg ccg ttc aag 259Gln Pro Val Ile Met Gly Arg Arg Thr Trp Glu Ser Leu Pro Phe Lys

40 45 50ccg ctt ccc ggc cgc gag aac ttc att ctc tcc tca cgc gag ccc ggc 307Pro Leu Pro Gly Arg Glu Asn Phe Ile Leu Ser Ser Arg Glu Pro Gly

55 60 65gac tgg tcc gcc ggc ggc aca gtg gtc acc gaa atc cct aaa agc ggc 355Asp Trp Ser Ala Gly Gly Thr Val Val Thr Glu Ile Pro Lys Ser Gly 70 75 80 85tgg atc atg ggc ggc ggc gag gtc tac aag gcc acc gtc ggc agc gcc 403Trp Ile Met Gly Gly Gly Glu Val Tyr Lys Ala Thr Val Gly Ser Ala

90 95 100gac gtt tta gaa ata acg ctt atc gac gcc acc ttc gat gtt tcc act 451Asp Val Leu Glu Ile Thr Leu Ile Asp Ala Thr Phe Asp Val Ser Thr

105 110 115ccc gtc tac gca ccc gaa atc ccg gcg aac ttc aac ctc gat gac gaa 499Pro Val Tyr Ala Pro Glu Ile Pro Ala Asn Phe Asn Leu Asp Asp Glu

120 125 130tcc gag tgg ttt acc tca ggc gag tat cgt tac aag ttc cag cgc tac 547Ser Glu Trp Phe Thr Ser Gly Glu Tyr Arg Tyr Lys Phe Gln Arg Tyr

135140145 atc aag gtt taaggagcaa acaacatgag caa 579Ile Lys Val150<210>680<211>152<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>680Met Ile Gly Ala Ile Trp Ala Gln Gly Arg Asp Gly Ile Ile Gly Asp 151015 Gly Thr Asp Met Pro Trp His Ile Pro Glu Asp Leu Lys His Phe Lys

20 25 30Lys Thr Thr Met Gly Gln Pro Val Ile Met Gly Arg Arg Thr Trp Glu

35 40 45Ser Leu Pro Phe Lys Pro Leu Pro Gly Arg Glu Asn Phe Ile Leu Ser

50 55 60Ser Arg Glu Pro Gly Asp Trp Ser Ala Gly Gly Thr Val Val Thr Glu 65 70 75 80Ile Pro Lys Ser Gly Trp Ile Met Gly Gly Gly Glu Val Tyr Lys Ala

85 90 95Thr Val Gly Ser Ala Asp Val Leu Glu Ile Thr Leu Ile Asp Ala Thr

100 105 110Phe Asp Val Ser Thr Pro Val Tyr Ala Pro Glu Ile Pro Ala Asn Phe

115 120 125Asn Leu Asp Asp Glu Ser Glu Trp Phe Thr Ser Gly Glu Tyr Arg Tyr

130135140 Lys Phe Gln Arg Tyr Ile Lys Val 145150<210>681<211>1044<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220>CDS<222>(101).)

Met Gln Arg Met Thr

1 5ccg agt tct cct gaa gtt cgt aat cgt ccg agc gct gcg cct gaa gag 163Pro Ser Ser Pro Glu Val Arg Asn Arg Pro Ser Ala Ala Pro Glu Glu

10 15 20cgt cag ttt gtg ctc act ttt ggc tgc cct gac tcc act gga att gtg 211Arg Gln Phe Val Leu Thr Phe Gly Cys Pro Asp Ser Thr Gly Ile Val

25 30 35gcg aag ttg tcg tcg ttc cta gct gag cgt ggg ggt tgg att act gag 259Ala Lys Leu Ser Ser Phe Leu Ala Glu Arg Gly Gly Trp Ile Thr Glu

40 45 50gct gga tat ttc acg gat cct gat tcg aat tgg ttc ttt act cgt cag 307Ala Gly Tyr Phe Thr Asp Pro Asp Ser Asn Trp Phe Phe Thr Arg Gln

55 60 65gcg att cgc gct gag tcg att gat acc acg att gag cag ttg cgg gag 355Ala Ile Arg Ala Glu Ser Ile Asp Thr Thr Ile Glu Gln Leu Arg Glu 70 75 80 85gag ttc gct ccg ctt gcg gag gag ttc ggc ccg agg gct aag tgg agt 403Glu Phe Ala Pro Leu Ala Glu Glu Phe Gly Pro Arg Ala Lys Trp Ser

90 95 100ttc act gac act gcg cag gtg aag aag gct gtg ttg ttg gtg tct aag 451Phe Thr Asp Thr Ala Gln Val Lys Lys Ala Val Leu Leu Val Ser Lys

105 110 115gag ggc cac tgc ttg cac gat ttg tta ggt cgt gtg gct gag aat gat 499Glu Gly His Cys Leu His Asp Leu Leu Gly Arg Val Ala Glu Asn Asp

120 125 130tat ccg atg gaa gtt gtt gcg gtt gtg ggt aac cat gag aac ttg cgt 547Tyr Pro Met Glu Val Val Ala Val Val Gly Asn His Glu Asn Leu Arg

135 140 145tat att gcg gag aac cat aat gtt ccg ttt ttc cat gtg ccg ttt cct 595Tyr Ile Ala Glu Asn His Asn Val Pro Phe Phe His Val Pro Phe Pro150 155 160 165aag gat gcg gtt ggt aag cgg aag gcg ttt gac cag gtc gct gag att 643Lys Asp Ala Val Gly Lys Arg Lys Ala Phe Asp Gln Val Ala Glu Ile

170 175 180gtg aat ggt tat gat ccg gat gcg att gtt ttg gct cgt ttt atg cag 691Val Asn Gly Tyr Asp Pro Asp Ala Ile Val Leu Ala Arg Phe Met Gln

185 190 195att ttg ccg ccg gat ttg tgt gag atg tgg gct ggt cgt gtg ttg aat 739Ile Leu Pro Pro Asp Leu Cys Glu Met Trp Ala Gly Arg Val Leu Asn

200 205 210att cat cac agt ttc ttg ccg tcg ttt atg ggt gcg cgc ccg tat cat 787Ile His His Ser Phe Leu Pro Ser Phe Met Gly Ala Arg Pro Tyr His

215 220 225cag gcg tat agc cgt ggt gtg aag ttg att ggt gcg acc tgc cat tat 835Gln Ala Tyr Ser Arg Gly Val Lys Leu Ile Gly Ala Thr Cys His Tyr230 235 240 245gcg act ggg gat ctg gat gat ggt ccg atc att gag cag gat gtt att 883Ala Thr Gly Asp Leu Asp Asp Gly Pro Ile Ile Glu Gln Asp Val Ile

250 255 260cgt gtg acg cat aag gat acg ccg act gag atg cag cgt ttg ggc cgc 931Arg Val Thr His Lys Asp Thr Pro Thr Glu Met Gln Arg Leu Gly Arg

265 270 275gat gcg gag aag cag gtg ctg gct cgc ggt ttg cgt ttc cac ttg gag 979Asp Ala Glu Lys Gln Val Leu Ala Arg Gly Leu Arg Phe His Leu Glu

280 285 290gac cgg gtg ctg gtt tac ggt aac cgc acg gtt gtc ttt gat 1021Asp Arg Val Leu Val Tyr Gly Asn Arg Thr Val Val Phe Asp

295300305 taaggctttt tgcttttcga cgc 1044<210>682<211>307<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>682Met Gln Arg Met Thr Pro Ser Ser Pro Glu Val Arg Asn Arg Pro Ser 151015 Ala Ala Pro Glu Glu Arg Gln Phe Val Leu Thr Phe Gly Cys Pro Asp

20 25 30Ser Thr Gly Ile Val Ala Lys Leu Ser Ser Phe Leu Ala Glu Arg Gly

35 40 45Gly Trp Ile Thr Glu Ala Gly Tyr Phe Thr Asp Pro Asp Ser Asn Trp

50 55 60Phe Phe Thr Arg Gln Ala Ile Arg Ala Glu Ser Ile Asp Thr Thr Ile 65 70 75 80Glu Gln Leu Arg Glu Glu Phe Ala Pro Leu Ala Glu Glu Phe Gly Prc

85 90 95Arg Ala Lys Trp Ser Phe Thr Asp Thr Ala Gln Val Lys Lys Ala Val

100 105 110Leu Leu Val Ser Lys Glu Gly His Cys Leu His Asp Leu Leu Gly Arg

115 120 125Val Ala Glu Asn Asp Tyr Pro Met Glu Val Val Ala Val Val Gly Asn

130 135 140His Glu Asn Leu Arg Tyr Ile AlaGlu Asn His Asn Val Pro Phe Phe145 150 155 160His Val Pro Phe Pro Lys Asp Ala Val Gly Lys Arg Lys Ala Phe Asp

165 170 175Gln Val Ala Glu Ile Val Asn Gly Tyr Asp Pro Asp Ala Ile Val Leu

180 185 190Ala Arg Phe Met Gln Ile Leu Pro Pro Asp Leu Cys Glu Met Trp Ala

195 200 205Gly Arg Val Leu Asn Ile His His Ser Phe Leu Pro Ser Phe Met Gly

210 215 220Ala Arg Pro Tyr His Gln Ala Tyr Ser Arg Gly Val Lys Leu Ile Gly225 230 235 240Ala Thr Cys His Tyr Ala Thr Gly Asp Leu Asp Asp Gly Pro Ile Ile

245 250 255Glu Gln Asp Val Ile Arg Val Thr His Lys Asp Thr Pro Thr Glu Met

260 265 270Gln Arg Leu Gly Arg Asp Ala Glu Lys Gln Val Leu Ala Arg Gly Leu

275 280 285Arg Phe His Leu Glu Asp Arg Val Leu Val Tyr Gly Asn Arg Thr Val

290295300 ValPhe Asp305<210>683<211>582<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(23). (559)<223>FRXA01321<400>683cttgcacgat ttgttaggtc gt gtg gct gag aat gat tat ccg atg gaa gtt 52

Val Ala Glu Asn Asp Tyr Pro Met Glu Val

1 5 10gtt gcg gtt gtg ggt aac cat gag aac ttg cgt tat att gcg gag aac 100Val Ala Val Val Gly Asn His Glu Asn Leu Arg Tyr Ile Ala Glu Asn

15 20 25cat aat gtt ccg ttt ttc cat gtg ccg ttt cct aag gat gcg gtt ggt 148His Asn Val Pro Phe Phe His Val Pro Phe Pro Lys Asp Ala Val Gly

30 35 40aag cgg aag gcg ttt gac cag gtc gct gag att gtg aat ggt tat gat 196Lys Arg Lys Ala Phe Asp Gln Val Ala Glu Ile Val Asn Gly Tyr Asp

45 50 55ccg gat gcg att gtt ttg gct cgt ttt atg cag att ttg ccg ccg gat 244Pro Asp Ala Ile Val Leu Ala Arg Phe Met Gln Ile Leu Pro Pro Asp

60 65 70ttg tgt gag atg tgg gct ggt cgt gtg ttg aat att cat cac agt ttc 292Leu Cys Glu Met Trp Ala Gly Arg Val Leu Asn Ile His His Ser Phe 75 80 85 90ttg ccg tcg ttt atg ggt gcg cgc ccg tat cat cag gcg tat agc cgt 340Leu Pro Ser Phe Met Gly Ala Arg Pro Tyr His Gln Ala Tyr Ser Arg

95 100 105ggt gtg aag ttg att ggt gcg acc tgc cat tat gcg act ggg gat ctg 388Gly Val Lys Leu Ile Gly Ala Thr Cys His Tyr Ala Thr Gly Asp Leu

110 115 120gat gat ggt ccg atc att gag cag gat gtt att cgt gtg acg cat aag 436Asp Asp Gly Pro Ile Ile Glu Gln Asp Val Ile Arg Val Thr His Lys

125 130 135gat acg ccg act gag atg cag cgt ttg ggc cgc gat gcg gag aag cag 484Asp Thr Pro Thr Glu Met Gln Arg Leu Gly Arg Asp Ala Glu Lys Gln

140 145 150gtg ctg gct cgc ggt ttg cgt ttc cac ttg gag gac cgg gtg ctg gtt 532Val Leu Ala Arg Gly Leu Arg Phe His Leu Glu Asp Arg Val Leu Val155 160 165 170tac ggt aac cgc acg gtt gtc ttt gat taaggctttt tgcttttcga 579Tyr Gly Asn Arg Thr Val Val Phe Asp

175cgc 582<210>684<211>179<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>684Val Ala Glu Asn Asp Tyr Pro Met Glu Val Val Ala Val Val Gly Asn 151015 His Glu Asn Leu Arg Tyr Ile Ala Glu Asn His Asn Val Pro Phe Phe

20 25 30His Val Pro Phe Pro Lys Asp Ala Val Gly Lys Arg Lys Ala Phe Asp

35 40 45Gln Val Ala Glu Ile Val Asn Gly Tyr Asp Pro Asp Ala Ile Val Leu

50 55 60Ala Arg Phe Met Gln Ile Leu Pro Pro Asp Leu Cys Glu Met Trp Ala 65 70 75 80Gly Arg Val Leu Asn Ile His His Ser Phe Leu Pro Ser Phe Met Gly

85 90 95Ala Arg Pro Tyr His Gln Ala Tyr Ser Arg Gly Val Lys Leu Ile Gly

100 105 110Ala Thr Cys His Tyr Ala Thr Gly Asp Leu Asp Asp Gly Pro Ile Ile

115 120 125Glu Gln Asp Val Ile Arg Val Thr His Lys Asp Thr Pro Thr Glu Met

130 135 140Gln Arg Leu Gly Arg Asp Ala Glu Lys Gln Val Leu Ala Arg Gly Leu145 150 155 160Arg Phe His Leu Glu Asp Arg Val Leu Val Tyr Gly Asn Arg Thr Val

165170175 Val Phe Asp<210>685<211>975<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (952)<223>RXA00461<400>685tgttgggagg gatgacagga ttgtcgaaga taacgtgaag tgggtgttcc ggcatgtgtt 60tgattgtaag gccttggaaa agggtggaat aatagcgggc gtg act gca atc aaa 115

Val Thr Ala Ile Lys

1 5ctt gat gga aac tta tac cgc ggg gaa att ttc gcc gac ttg gaa cag 163Leu Asp Gly Asn Leu Tyr Arg Gly Glu Ile Phe Ala Asp Leu Glu Gln

10 15 20cgc gtt gct gcg ttg aag gag aaa ggg att gtg ccg ggg ctt gcc acc 211Arg Val Ala Ala Leu Lys Glu Lys Gly Ile Val Pro Gly Leu Ala Thr

25 30 35gtg ctg gtg ggt gat gac cca gcg agc cac tct tac gtg aag atg aag 259Val Leu Val Gly Asp Asp Pro Ala Ser His Ser Tyr Val Lys Met Lys

40 45 50cat cgt gac tgt gag cag att ggt gtg aac tcg atc cgt aag gat ctg 307His Arg Asp Cys Glu Gln Ile Gly Val Asn Ser Ile Arg Lys Asp Leu

55 60 65cct gct gat gtc acg cag gaa gag ctt ttc gct gtc atc gat gaa ctg 355Pro Ala Asp Val Thr Gln Glu Glu Leu Phe Ala Val Ile Asp Glu Leu 70 75 80 85aac aac gat gat tct tgc act ggt tac att gtg cag ctt cct ttg cct 403Asn Asn Asp Asp Ser Cys Thr Gly Tyr Ile Val Gln Leu Pro Leu Pro

90 95 100aag cac ttg gac gaa aac gct gtg ctg gag cgc att gat cca gct aag 451Lys His Leu Asp Glu Asn Ala Val Leu Glu Arg Ile Asp Pro Ala Lys

105 110 115gat gct gat ggc ctg cac cct gta aac ctg ggc aag ctt gtg ctc aac 499Asp Ala Asp Gly Leu His Pro Val Asn Leu Gly Lys Leu Val Leu Asn

120 125 130gag cca gct cca ctg cca tgc acc ccg aat ggttcc atc agc ttg ttg 547Glu Pro Ala Pro Leu Pro Cys Thr Pro Asn Gly Ser Ile Ser Leu Leu

135 140 145cgt cgt ttc ggc gtt gag ctt gat ggc gcg aag gtt gtt gtc att ggc 595Arg Arg Phe Gly Val Glu Leu Asp Gly Ala Lys Val Val Val Ile Gly150 155 160 165cgt ggc gtc acc gtt ggt cgc cca att ggc ctg atg ctg acc cgc cgt 643Arg Gly Val Thr Val Gly Arg Pro Ile Gly Leu Met Leu Thr Arg Arg

170 175 180tcc gag aac tcc acg gtt act ttg tgc cac act ggc acg aag gat ctg 691Ser Glu Asn Ser Thr Val Thr Leu Cys His Thr Gly Thr Lys Asp Leu

185 190 195gct gcg gag acc cgt gcg gct gac gtc atc att gct gca gct ggt cag 739Ala Ala Glu Thr Arg Ala Ala Asp Val Ile Ile Ala Ala Ala Gly Gln

200 205 210ccg cac atg ctg acc gca gac atg gtc aag cca ggc gca gcg gtg ctc 787Pro His Met Leu Thr Ala Asp Met Val Lys Pro Gly Ala Ala Val Leu

215 220 225gat gtc ggc gtc tcc cgc aag gac ggc aag ttg ctt ggc gac gtc cac 835Asp Val Gly Val Ser Arg Lys Asp Gly Lys Leu Leu Gly Asp Val His230 235 240 245ccc gac gtg tgg gaa gtc gcc ggc gcg gtc tca cca aac cca ggc ggc 883Pro Asp Val Trp Glu Val Ala Gly Ala Val Ser Pro Asn Pro Gly Gly

250 255 260gtt ggc cct ctg acc cgt gca ttc ttg gtg cac aat gtt gtc gag cgc 931Val Gly Pro Leu Thr Arg Ala Phe Leu Val His Asn Val Val Glu Arg

265 270 275gct gaa aag ctg gct gga ctc taaaaacaca tgactaatcc cgg 975Ala Glu Lys Leu Ala Gly Leu

280<210>686<211>284<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>686Val Thr Ala Ile Lys Leu Asp Gly Asn Leu Tyr Arg Gly Glu Ile Phe 151015 Ala Asp Leu Glu Gln Arg Val Ala Ala Leu Lys Glu Lys Gly Ile Val

20 25 30Pro Gly Leu Ala Thr Val Leu Val Gly Asp Asp Pro Ala Ser His Ser

35 40 45Tyr Val Lys Met Lys His Arg Asp Cys Glu Gln Ile Gly Val Asn Ser

50 55 60Ile Arg Lys Asp Leu Pro Ala Asp Val Thr Gln Glu Glu Leu Phe Ala 65 70 75 80Val Ile Asp Glu Leu Asn Asn Asp Asp Ser Cys Thr Gly Tyr Ile Val

85 90 95Gln Leu Pro Leu Pro Lys His Leu Asp Glu Asn Ala Val Leu Glu Arg

100 105 110Ile Asp Pro Ala Lys Asp Ala Asp Gly Leu His Pro Val Asn Leu Gly

115 120 125Lys Leu Val Leu Asn Glu Pro Ala Pro Leu Pro Cys Thr Pro Asn Gly

130 135 140Ser Ile Ser Leu Leu Arg Arg Phe Gly Val Glu Leu Asp Gly Ala Lys145 150 155 160Val Val Val Ile Gly Arg Gly Val Thr Val Gly Arg Pro Ile Gly Leu

165 170 175Met Leu Thr Arg Arg Ser Glu Asn Ser Thr Val Thr Leu Cys His Thr

180 185 190Gly Thr Lys Asp Leu Ala Ala Glu Thr Arg Ala Ala Asp Val Ile Ile

195 200 205Ala Ala Ala Gly Gln Pro His Met Leu Thr Ala Asp Met Val Lys Pro

210 215 220Gly Ala Ala Val Leu Asp Val Gly Val Ser Arg Lys Asp Gly Lys Leu225 230 235 240Leu Gly Asp Val His Pro Asp Val Trp Glu Val Ala Gly Ala Val Ser

245 250 255Pro Asn Pro Gly Gly Val Gly Pro Leu Thr Arg Ala Phe Leu Val His

260 265 270Asn Val Val Glu Arg Ala Glu Lys Leu Ala Gly Leu

275280<210>687<211>711<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (688)<223>RXA01514<400>687accacagaaa tgcctgtcgt tccagatcag cccatcgatg gtgattccgg gaagtccgct 60gagggcacac aggagaatcc ggaaaatgaa ggagacaacc gtg gat aac cac gct 115

Val Asp Asn His Ala

1 5gca gtt cgc gag ttc gat gag gag cgc gca aca gct gcg att cgt gag 163Ala Val Arg Glu Phe Asp Glu Glu Arg Ala Thr Ala Ala Ile Arg Glu

10 15 20ttg ctc atc gct gtg ggt gag gat cca gat cgc gaa ggc ctg ttg gaa 211Leu Leu Ile Ala Val Gly Glu Asp Pro Asp Arg Glu Gly Leu Leu Glu

25 30 35acc cca gct cga gtg gct agg gcg tac aag gaa act ttc gcg ggt ctg 259Thr Pro Ala Arg Val Ala Arg Ala Tyr Lys Glu Thr Phe Ala Gly Leu

40 45 50cat gag gat ccc acc act gtg ctg gag aag acg ttc tct gag ggc cat 307His Glu Asp Pro Thr Thr Val Leu Glu Lys Thr Phe Ser Glu Gly His

55 60 65gaa gag ttg gtt ctg gtt cgt gag atc ccg att tac tcc atg tgt gag 355Glu Glu Leu Val Leu Val Arg Glu Ile Pro Ile Tyr Ser Met Cys Glu 70 75 80 85cac cac ttg gtg ccg ttc ttt ggc gtg gcg cac att ggt tac att ccg 403His His Leu Val Pro Phe Phe Gly Val Ala His Ile Gly Tyr Ile Pro

90 95 100ggt aag tcc ggc aag gtg act ggc ctg tcc aag ctg gcg cgt tta gcg 451Gly Lys Ser Gly Lys Val Thr Gly Leu Ser Lys Leu Ala Arg Leu Ala

105 110 115gat atg ttt gct aag cga cct cag gtt cag gag cgc ttg acc tcc caa 499Asp Met Phe Ala Lys Arg Pro Gln Val Gln Glu Arg Leu Thr Ser Gln

120 125 130att gcg gat gct ctc gtc gaa aag ctt gat gcc cag gcc gtg gcc gtg 547Ile Ala Asp Ala Leu Val Glu Lys Leu Asp Ala Gln Ala Val Ala Val

135 140 145gtg att gaa gct gag cac ctg tgc atg gcc atg cgc gga atc cgt aag 595Val Ile Glu Ala Glu His Leu Cys Met Ala Met Arg Gly Ile Arg Lys150 155 160 165cct ggt gct gtg acc acg acg tct gcg gtg cgc ggc ggt ttt aag aac 643Pro Gly Ala Val Thr Thr Thr Ser Ala Val Arg Gly Gly Phe Lys Asn

170 175 180aac gct gcc tcc cgc gct gag gtg ttc tcc ctg att cgg ggg cac 688Asn Ala Ala Ser Arg Ala Glu Val Phe Ser Leu Ile Arg Gly His

185190195 taaatgaacg tatcctcttt gac 711<711>688<211>196<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>688Val Asp Asn His Ala Ala Val Arg Glu Phe Asp Glu Glu Arg Ala Thr 151015 Ala Ala Ile Arg Glu Leu Leu Ile Ala Val Gly Glu Asp Pro Asp Arg

20 2530Glu Gly Leu Leu Glu Thr Pro Ala Arg Val Ala Arg Ala Tyr Lys Glu

35 40 45Thr Phe Ala Gly Leu His Glu Asp Pro Thr Thr Val Leu Glu Lys Thr

50 55 60Phe Ser Glu Gly His Glu Glu Leu Val Leu Val Arg Glu Ile Pro Ile 65 70 75 80Tyr Ser Met Cys Glu His His Leu Val Pro Phe Phe Gly Val Ala His

85 90 95Ile Gly Tyr Ile Pro Gly Lys Ser Gly Lys Val Thr Gly Leu Ser Lys

100 105 110Leu Ala Arg Leu Ala Asp Met Phe Ala Lys Arg Pro Gln Val Gln Glu

115 120 125Arg Leu Thr Ser Gln Ile Ala Asp Ala Leu Val Glu Lys Leu Asp Ala

130 135 140Gln Ala Val Ala Val Val Ile Glu Ala Glu His Leu Cys Met Ala Met145 150 155 160Arg Gly Ile Arg Lys Pro Gly Ala Val Thr Thr Thr Ser Ala Val Arg

165 170 175Gly Gly Phe Lys Asn Asn Ala Ala Ser Arg Ala Glu Val Phe Ser Leu

180 185 190Ile Arg Gly His

195<210>689<211>513<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (490)<223>RXA01516<400>689tctgcacata tgggagcatg gggtgtgcgc gtgcacgatg tcccagtatc aagggacgct 60gttgatgttg ccgcattgtg gcgaagtgga ggaactcacc atg gct gat cgt att 115

Met Ala Asp Arg Ile

1 5gaa ctt aaa ggc ctt gaa tgc ttc gga cac cac ggt gtg ttc gac ttt 163Glu Leu Lys Gly Leu Glu Cys Phe Gly His His Gly Val Phe Asp Phe

10 15 20gaa aaa gag caa ggc cag ccc ttc att gtg gat gtc acc tgc tgg atg 211Glu Lys Glu Gln Gly Gln Pro Phe Ile Val Asp Val Thr Cys Trp Met

25 30 35gat ttc gat gcc gca ggt gcc agc gat gac ctt tcc gac acc gta gat 259Asp Phe Asp Ala Ala Gly Ala Ser Asp Asp Leu Ser Asp Thr Val Asp

40 45 50tac ggc gcg ttg gca ttg ttg gtt gct gaa atc gtg gaa ggc cca tcc 307Tyr Gly Ala Leu Ala Leu Leu Val Ala Glu Ile Val Glu Gly Pro Ser

55 60 65agg gat ttg atc gag acg gtg gcc acg gaa tct gcg gat gct gtg atg 355Arg Asp Leu Ile Glu Thr Val Ala Thr Glu Ser Ala Asp Ala Val Met 70 75 80 85gct aaa ttt gat gcg ctt cat gcg gtg gaa gta acc atc cat aag ccc 403Ala Lys Phe Asp Ala Leu His Ala Val Glu Val Thr Ile His Lys Pro

90 95 100aaa gca ccg atc cca cgt act ttt gct gac gtc gcg gtg gtt gcc cga 451Lys Ala Pro Ile Pro Arg Thr Phe Ala Asp Val Ala Val Val Ala Arg

105 110 115cgt tcc agg aaa tcc atg gct gct gga agg agc aac gcc taatgcatgc 500Arg Ser Arg Lys Ser Met Ala Ala Gly Arg Ser Asn Ala

120125130 agttttgtcc atc 513<210>690<211>130<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>690Met Ala Asp Arg Ile Glu Leu Lys Gly Leu Glu Cys Phe Gly His His 151015 Gly Val Phe Asp Phe Glu Lys Glu Gln Gly Gln Pro Phe Ile Val Asp

20 25 30Val Thr Cys Trp Met Asp Phe Asp Ala Ala Gly Ala Ser Asp Asp Leu

35 40 45Ser Asp Thr Val Asp Tyr Gly Ala Leu Ala Leu Leu Val Ala Glu Ile

50 55 60Val Glu Gly Pro Ser Arg Asp Leu Ile Glu Thr Val Ala Thr Glu Ser 65 70 75 80Ala Asp Ala Val Met Ala Lys Phe Asp Ala Leu His Ala Val Glu Val

85 90 95Thr Ile His Lys Pro Lys Ala Pro Ile Pro Arg Thr Phe Ala Asp Val

100 105 110Ala Val Val Ala Arg Arg Ser Arg Lys Ser Met Ala Ala Gly Arg Ser

115 120 125Asn Ala

130<210>691<211>975<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (952)<223>RXA01515<400>691taagcctggt gctgtgacca cgacgtctgc ggtgcgcggc ggttttaaga acaacgctgc 60ctcccgcgct gaggtgttct ccctgattcg ggggcactaa atg aac gta tcc tct 115

Met Asn Val Ser Ser

1 5ttg acc atc ccg gga cgc tgt ttg gtc atg gga att gtc aat gtc act 163Leu Thr Ile Pro Gly Arg Cys Leu Val Met Gly Ile Val Asn Val Thr

10 15 20gag gat tcc ttt tcg gac ggt ggc aag tac att gac gtt gat cag gcg 211Glu Asp Ser Phe Ser Asp Gly Gly Lys Tyr Ile Asp Val Asp Gln Ala

25 30 35atc gcg cat gcc aag gaa ttg gtg gct gct ggc gcc gac atg att gat 259Ile AlaHis Ala Lys Glu Leu Val Ala Ala Gly Ala Asp Met Ile Asp

40 45 50gtc ggc ggc gag tcc acc cgg cct ggg gca gtg cgc gtc gac gcg tcc 307Val Gly Gly Glu Ser Thr Arg Pro Gly Ala Val Arg Val Asp Ala Ser

55 60 65gtg gaa cgg gac cgg gtt gtg ccg gtc att aag gcg ctt cac gac gcc 355Val Glu Arg Asp Arg Val Val Pro Val Ile Lys Ala Leu His Asp Ala 70 75 80 85ggc atc cac act tcc gta gac acc atg cgg gcc tcc gtg gcg cag gct 403Gly Ile His Thr Ser Val Asp Thr Met Arg Ala Ser Val Ala Gln Ala

90 95 100gcc gcg ggc gct ggc gtc tcc atg atc aac gac gtc tct ggc ggt ttg 451Ala Ala Gly Ala Gly Val Ser Met Ile Asn Asp Val Ser Gly Gly Leu

105 110 115gct gat cct gag atg ttt tct gtc atg gcg gaa gcg caa att ccc gtg 499Ala Asp Pro Glu Met Phe Ser Val Met Ala Glu Ala Gln Ile Pro Val

120 125 130tgt ttg atg cac tgg cgc acc ctc caa ttc ggt gat gcc gca ggt cag 547Cys Leu Met His Trp Arg Thr Leu Gln Phe Gly Asp Ala Ala Gly Gln

135 140 145gca gat cac ggt gga gac gtt gta gcc gat gtg cac gca gtg ctt gat 595Ala Asp His Gly Gly Asp Val Val Ala Asp Val His Ala Val Leu Asp150 155 160 165gat ctt gtc gcc cgc gcc acc gct gct ggt gtg gcc gaa aac cag atc 643Asp Leu Val Ala Arg Ala Thr Ala Ala Gly Val Ala Glu Asn Gln Ile

170 175 180gtg ctt gat cca ggt ttg ggt ttt gcc aaa tca cgt gaa gac aac tgg 691Val Leu Asp Pro Gly Leu Gly Phe Ala Lys Ser Arg Glu Asp Asn Trp

185 190 195cgt ttg ctg caa gca ctg ccc gag ttt att tct gga cct ttc ccc atc 739Arg Leu Leu Gln Ala Leu Pro Glu Phe Ile Ser Gly Pro Phe Pro Ile

200 205 210ctg gtg gga gca tcc cgg aag cga ttc ctg gct ggc gtg cgc aaa gac 787Leu Val Gly Ala Ser Arg Lys Arg Phe Leu Ala Gly Val Arg Lys Asp

215 220 225cgt ggc cta gat gtc acc ccc att gat gcc gac cca gca acc gca gcg 835Arg Gly Leu Asp Val Thr Pro Ile Asp Ala Asp Pro Ala Thr Ala Ala230 235 240 245gtg acc gca gtg tct gca cat atg gga gca tgg ggt gtg cgc gtg cac 883Val Thr Ala Val Ser Ala His Met Gly Ala Trp Gly Val Arg Val His

250 255 260gat gtc cca gta tca agg gac gct gtt gat gtt gcc gca ttg tgg cga 931Asp Val Pro Val Ser Arg Asp Ala Val Asp Val Ala Ala Leu Trp Arg

265 270 275agt gga gga act cac cat ggc tgatcgtatt gaacttaaag gcc 975Ser Gly Gly Thr His His Gly

280<210>692<211>284<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>692Met Asn Val Ser Ser Leu Thr Ile Pro Gly Arg Cys Leu Val Met Gly 151015 Ile Val Asn Val Thr Glu Asp Ser Phe Ser Asp Gly Gly Lys Tyr Ile

20 25 30Asp Val Asp Gln Ala Ile Ala His Ala Lys Glu Leu Val Ala Ala Gly

35 40 45Ala Asp Met Ile Asp Val Gly Gly Glu Ser Thr Arg Pro Gly Ala Val

50 55 60Arg Val Asp Ala Ser Val Glu Arg Asp Arg Val Val Pro Val Ile Lys 65 70 75 80AlaLeu His Asp Ala Gly Ile His Thr Ser Val Asp Thr Met Arg Ala

85 90 95Ser Val Ala Gln Ala Ala Ala Gly Ala Gly Val Ser Met Ile Asn Asp

100 105 110Val Ser Gly Gly Leu Ala Asp Pro Glu Met Phe Ser Val Met Ala Glu

115 120 125Ala Gln Ile Pro Val Cys Leu Met His Trp Arg Thr Leu Gln Phe Gly

130 135 140Asp Ala Ala Gly Gln Ala Asp His Gly Gly Asp Val Val Ala Asp Val145 150 155 160His Ala Val Leu Asp Asp Leu Val Ala Arg Ala Thr Ala Ala Gly Val

165 170 175Ala Glu Asn Gln Ile Val Leu Asp Pro Gly Leu Gly Phe Ala Lys Ser

180 185 190Arg Glu Asp Asn Trp Arg Leu Leu Gln Ala Leu Pro Glu Phe Ile Ser

195 200 205Gly Pro Phe Pro Ile Leu Val Gly Ala Ser Arg Lys Arg Phe Leu Ala

210 215 220Gly Val Arg Lys Asp Arg Gly Leu Asp Val Thr Pro Ile Asp Ala Asp225 230 235 240Pro Ala Thr Ala Ala Val Thr Ala Val Ser Ala His Met Gly Ala Trp

245 250 255Gly Val Arg Val His Asp Val Pro Val Ser Arg Asp Ala Val Asp Val

260 265 270Ala Ala Leu Trp Arg Ser Gly Gly Thr His His Gly

275280<210>693<211>859<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (859)<223>RXA02024<400>693cactgatgac ctggatcagg ccgtcaaatt catcgtcgat gcacacgctg gattggacgt 60agcgcgtctc cacaattaag cagtggctac attaggtgtt atg agt tct ttg ccg 115

Met Ser Ser Leu Pro

1 5gtc atc atg gcc atc gtc aat cgc acc ccg gat tct ttc tat gac aag 163Val Ile Met Ala Ile Val Asn Arg Thr Pro Asp Ser Phe Tyr Asp Lys

10 15 20ggt gcg aca ttt gag gac acc gct gcg cta aac agg gca gcg gag gtc 211Gly Ala Thr Phe Glu Asp Thr Ala Ala Leu Asn Arg Ala Ala Glu Val

25 30 35att gaa caa ggc gcc ggc att gtc gat atc ggt ggg gtg aaa gcc ggc 259Ile Glu Gln Gly Ala Gly Ile Val Asp Ile Gly Gly Val Lys Ala Gly

40 45 50ccg ggg gat ttc gtg tcg gcg gag gaa gag atc gac cgc gtg gtg cca 307Pro Gly Asp Phe Val Ser Ala Glu Glu Glu Ile Asp Arg Val Val Pro

55 60 65atc atc gct gcg gtg cga gaa cgt ttt cct gac att gat att tct gtt 355Ile Ile Ala Ala Val Arg Glu Arg Phe Pro Asp Ile Asp Ile Ser Val 70 75 80 85gat acc tgg cgg gcg tcg gtg gct gat gtc gca gtg gcg cat gga gca 403Asp Thr Trp Arg Ala Ser Val Ala Asp Val Ala Val Ala His Gly Ala

90 95 100acg ctg atc aat gac act tgg gcc ggc cat gat cat gag ttg gtg cag 451Thr Leu Ile Asn Asp Thr Trp Ala Gly His Asp His Glu Leu Val Gln

105 110 115gta gca ggg cag cac aag gtg ggt tat gtc tgc tcg cac acc ggc ggg 499Val Ala Gly Gln His Lys Val Gly Tyr Val Cys Ser His Thr Gly Gly

120 125 130gtg att cca aga acg cga cca tat cgg gtg cat ttc gat gac atc gtg 547Val Ile Pro Arg Thr Arg Pro Tyr Arg Val His Phe Asp Asp Ile Val

135 140 145gcc gat gta att acg gag acc acc aaa ttg gca gag caa gct gtt cgt 595Ala Asp Val Ile Thr Glu Thr Thr Lys Leu Ala Glu Gln Ala Val Arg150 155 160 165gcc ggg gtg cca gag gaa cgg gtg ttt att gat ccc acc cat gat ttc 643Ala Gly Val Pro Glu Glu Arg Val Phe Ile Asp Pro Thr His Asp Phe

170 175 180ggg aaa aac acc ttc cac gga ctg gag ctt tta cga cgg atc gat gag 691Gly Lys Asn Thr Phe His Gly Leu Glu Leu Leu Arg Arg Ile Asp Glu

185 190 195gtg gtt gcc acg ggc tgg ccg gtg ctg atg gcc ttg agt aat aag gat 739Val Val Ala Thr Gly Trp Pro Val Leu Met Ala Leu Ser Asn Lys Asp

200 205 210ttc att ggg gaa act ttg gaa agg ggc gtc gat aag cgt gtt gct ggc 787Phe Ile Gly Glu Thr Leu Glu Arg Gly Val Asp Lys Arg Val Ala Gly

215 220 225acg ctt gct gcc act gcc tgg gcg gcg gcg cgc ggc gtt gcg gct ttt 835Thr Leu Ala Ala Thr Ala Trp Ala Ala Ala Arg Gly Val Ala Ala Phe230 235 240 245cgc gtg cat gaa gtt gcg gaa acc 859Arg Val His Glu Val Ala Glu Thr

250<210>694<211>253<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>694Met Ser Ser Leu Pro Val Ile Met Ala Ile Val Asn Arg Thr Pro Asp 151015 Ser Phe Tyr Asp Lys Gly Ala Thr Phe Glu Asp Thr Ala Ala Leu Asn

20 25 30Arg Ala Ala Glu Val Ile Glu Gln Gly Ala Gly Ile Val Asp Ile Gly

35 40 45Gly Val Lys Ala Gly Pro Gly Asp Phe Val Ser Ala Glu Glu Glu Ile

50 55 60Asp Arg Val Val Pro Ile Ile Ala Ala Val Arg Glu Arg Phe Pro Asp 65 70 75 80Ile Asp Ile Ser Val Asp Thr Trp Arg Ala Ser Val Ala Asp Val Ala

85 90 95Val Ala His Gly Ala Thr Leu Ile Asn Asp Thr Trp Ala Gly His Asp

100 105 110His Glu Leu Val Gln Val Ala Gly Gln His Lys Val Gly Tyr Val Cys

115 120 125Ser His Thr Gly Gly Val Ile Pro Arg Thr Arg Pro Tyr Arg Val His

130 135 140Phe Asp Asp Ile Val Ala Asp Val Ile Thr Glu Thr Thr Lys Leu Ala145 150 155 160Glu Gln Ala Val Arg Ala Gly Val Pro Glu Glu Arg Val Phe Ile Asp

165 170 175Pro Thr His Asp Phe Gly Lys Asn Thr Phe His Gly Leu Glu Leu Leu

180 185 190Arg Arg Ile Asp Glu Val Val Ala Thr Gly Trp Pro Val Leu Met Ala

195 200 205Leu Ser Asn Lys Asp Phe Ile Gly Glu Thr Leu Glu Arg Gly Val Asp

210 215 220Lys Arg Val Ala Gly Thr Leu Ala Ala Thr Ala Trp Ala Ala Ala Arg225 230 235240Gly Val Ala Ala Phe Arg Val His Glu Val Ala Glu Thr

245250<210>695<211>579<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (556)<223>RXA00106<400>695tggagctcaa caaggcagcg tacatgtttg agtacagctt cgatgacatc accgtgtccg 60gctacgatcc acacccattg atccgcggca aggtcgccgt atg atc ggt gcg att 115

Met Ile Gly Ala Ile

1 5tgg gca caa ggc cgt gac ggc atc atc ggc gac ggc acc gac atg ccc 163Trp Ala Gln Gly Arg Asp Gly Ile Ile Gly Asp Gly Thr Asp Met Pro

10 15 20tgg cac atc ccg gaa gac ctc aaa cac ttc aag aaa acc acc atg ggc 211Trp His Ile Pro Glu Asp Leu Lys His Phe Lys Lys Thr Thr Met Gly

25 30 35cag ccg gtc atc atg ggt cgt cgc acg tgg gag tct ttg ccg ttc aag 259Gln Pro Val Ile Met Gly Arg Arg Thr Trp Glu Ser Leu Pro Phe Lys

40 45 50ccg ctt ccc ggc cgc gag aac ttc att ctc tcc tca cgc gag ccc ggc 307Pro Leu Pro Gly Arg Glu Asn Phe Ile Leu Ser Ser Arg Glu Pro Gly

55 60 65gac tgg tcc gcc ggc ggc aca gtg gtc acc gaa atc cct aaa agc ggc 355Asp Trp Ser Ala Gly Gly Thr Val Val Thr Glu Ile Pro Lys Ser Gly 70 75 80 85tgg atc atg ggc ggc ggc gag gtc tac aag gcc acc gtc ggc agc gcc 403Trp Ile Met Gly Gly Gly Glu Val Tyr Lys Ala Thr Val Gly Ser Ala

90 95 100gac gtt tta gaa ata acg ctt atc gac gcc acc ttc gat gtt tcc act 451Asp Val Leu Glu IleThr Leu Ile Asp Ala Thr Phe Asp Val Ser Thr

105 110 115ccc gtc tac gca ccc gaa atc ccg gcg aac ttc aac ctc gat gac gaa 499Pro Val Tyr Ala Pro Glu Ile Pro Ala Asn Phe Asn Leu Asp Asp Glu

120 125 130tcc gag tgg ttt acc tca ggc gag tat cgt tac aag ttc cag cgc tac 547Ser Glu Trp Phe Thr Ser Gly Glu Tyr Arg Tyr Lys Phe Gln Arg Tyr

135140145 atc aag gtt taaggagcaa acaacatgag caa 579Ile Lys Val150<210>696<211>152<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>696Met Ile Gly Ala Ile Trp Ala Gln Gly Arg Asp Gly Ile Ile Gly Asp 151015 Gly Thr Asp Met Pro Trp His Ile Pro Glu Asp Leu Lys His Phe Lys

20 25 30Lys Thr Thr Met Gly Gln Pro Val Ile Met Gly Arg Arg Thr Trp Glu

35 40 45Ser Leu Pro Phe Lys Pro Leu Pro Gly Arg Glu Asn Phe Ile Leu Ser

50 55 60Ser Arg Glu Pro Gly Asp Trp Ser Ala Gly Gly Thr Val Val Thr Glu 65 70 75 80Ile Pro Lys Ser Gly Trp Ile Met Gly Gly Gly Glu Val Tyr Lys Ala

85 90 95Thr Val Gly Ser Ala Asp Val Leu Glu Ile Thr Leu Ile Asp Ala Thr

100 105 110Phe Asp Val Ser Thr Pro Val Tyr Ala Pro Glu Ile Pro Ala Asn Phe

115 120 125Asn Leu Asp Asp Glu Ser Glu Trp Phe Thr Ser Gly Glu Tyr Arg Tyr

130135140 Lys Phe Gln Arg Tyr Ile Lys Val 145150<210>697<211>1556<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220>CDS<222>(1).)

20 25 30ttg ccc atc gat ctc gcc ggt gag gta gaa gca cct gcc tcc gag gag 144Leu Pro Ile Asp Leu Ala Gly Glu ValGlu Ala Pro Ala Ser Glu Glu

35 40 45atc acc caa gaa gat ttg ctg cgc ctt gcc cag gtg gaa gca gag ttg 192Ile Thr Gln Glu Asp Leu Leu Arg Leu Ala Gln Val Glu Ala Glu Leu

50 55 60gat caa cgt tgg ttg gaa acc aaa att gat ccc act ttc cga cgc atg 240Asp Gln Arg Trp Leu Glu Thr Lys Ile Asp Pro Thr Phe Arg Arg Met 65 70 75 80agc tac atg atg gat ctc atg ggc caa cca cag aat tcc ttc cca gca 288Ser Tyr Met Met Asp Leu Met Gly Gln Pro Gln Asn Ser Phe Pro Ala

85 90 95att cac gtg gct ggc acc aac ggt aag acc tcc acc acc cgc atg atc 336Ile His Val Ala Gly Thr Asn Gly Lys Thr Ser Thr Thr Arg Met Ile

100 105 110gag tcg ttg ctg cgc gca ttc cac cgc cgc acc ggc cgg acc acc agc 384Glu Ser Leu Leu Arg Ala Phe His Arg Arg Thr Gly Arg Thr Thr Ser

115 120 125ccg cac ctg cag ctg gta acc gaa cgc atc gcg att gat ggc aag ccc 432Pro His Leu Gln Leu Val Thr Glu Arg Ile Ala Ile Asp Gly Lys Pro

130 135 140atc cac ccg cgt gat ttc gtg cgg atc tac gaa gag att aag ccc tac 480Ile His Pro Arg Asp Phe Val Arg Ile Tyr Glu Glu Ile Lys Pro Tyr145 150 155 160atg gag atg acc gac gcc tgg tca gag gcc gag ggc gga ccg aag atg 528Met Glu Met Thr Asp Ala Trp Ser Glu Ala Glu Gly Gly Pro LysMet

165 170 175agc aag ttt gag gca ctc gtg gcc ctc gct tac gca ggt ttt gcc gac 576Ser Lys Phe Glu Ala Leu Val Ala Leu Ala Tyr Ala Gly Phe Ala Asp

180 185 190gct cct gtt gac gtc gcc gtc gtt gag gtt ggt ctt ggc gga cgc tgg 624Ala Pro Val Asp Val Ala Val Val Glu Val Gly Leu Gly Gly Arg Trp

195 200 205gat gcc act aac gtg atc aac gca gct gtt tcc gtg atc acc ccg gtg 672Asp Ala Thr Asn Val Ile Asn Ala Ala Val Ser Val Ile Thr Pro Val

210 215 220ggc atg gac cac gtg gat cgc ctg ggc aac acc att ggt gaa atc gct 720Gly Met Asp His Val Asp Arg Leu Gly Asn Thr Ile Gly Glu Ile Ala225 230 235 240ggt gaa aag gcc ggc atc atc aag gct cgt cct gca tct gag gat ggc 768Gly Glu Lys Ala Gly Ile Ile Lys Ala Arg Pro Ala Ser Glu Asp Gly

245 250 255acc gag cct gag ggc aac gtt gtc atc gtg ggc aag cag gag cca gaa 816Thr Glu Pro Glu Gly Asn Val Val Ile Val Gly Lys Gln Glu Pro Glu

260 265 270gca atg aac gtg att ctg cag caa gcc gtg gac gtg gac gca gct gtt 864Ala Met Asn Val Ile Leu Gln Gln Ala Val Asp Val Asp Ala Ala Val

275 280 285gct cgt ttg aac atg gaa ttc ggc gtg gtg gaa tcc gcc att gcc gtt 912Ala Arg Leu Asn Met Glu Phe Gly Val Val Glu Ser Ala Ile Ala Val

290 295 300ggt gga cag cag ctc acc ctg aag ggt ttg ggc ggc gaa tac acc gac 960Gly Gly Gln Gln Leu Thr Leu Lys Gly Leu Gly Gly Glu Tyr Thr Asp305 310 315 320atc ttc ctc cca ctg tct ggc gcg cac caa gca gat aat gcc gcg gtt 1008Ile Phe Leu Pro Leu Ser Gly Ala His Gln Ala Asp Asn Ala Ala Val

325 330 335gct ctc gca gca gtg gaa gca ttt ttc ggt gca tcc gcc gga cgc cca 1056Ala Leu Ala Ala Val Glu Ala Phe Phe Gly Ala Ser Ala Gly Arg Pro

340 345 350ttg gat atc gac acg gtg cgc gaa ggc ttc gca caa gtt cag tcc cca 1104Leu Asp Ile Asp Thr Val Arg Glu Gly Phe Ala Gln Val Gln Ser Pro

355 360 365ggt cgc ctc gag cgc ctg cgc tct gca cca acc gtg ttc atc gac gca 1152Gly Arg Leu Glu Arg Leu Arg Ser Ala Pro Thr Val Phe Ile Asp Ala

370 375 380gct cac aac cca cac ggt gcc gca gca ctt ggt gca gca cta gac cgt 1200Ala His Asn Pro His Gly Ala Ala Ala Leu Gly Ala Ala Leu Asp Arg385 390 395 400gac ttt gag ttc cgt cgc ctc atc ggt gtc atc gga gtg ctc tgc gac 1248Asp Phe Glu Phe Arg Arg Leu Ile Gly Val Ile Gly Val Leu Cys Asp

405 410 415aag gat gcc cgc ggc atc ttg gaa tca ctt gag cca tac ctg cat gaa 1296Lys Asp Ala Arg Gly Ile Leu Glu Ser Leu Glu Pro Tyr Leu His Glu

420 425 430att gtg tgc acc cag act gcc tca gag cgc gca ttg gac gca tac gat 1344Ile Val Cys Thr Gln Thr Ala Ser Glu Arg Ala Leu Asp Ala Tyr Asp

435 440 445tta gct gaa tat gct cga gag atc tac ggc gat gag cgt gtg cac gtc 1392Leu Ala Glu Tyr Ala Arg Glu Ile Tyr Gly Asp Glu Arg Val His Val

450 455 460caa gaa gat ctt gct ggc gcg gta gaa ctc gct att gaa cta gca gaa 1440Gln Glu Asp Leu Ala Gly Ala ValGlu Leu Ala Ile Glu Leu Ala Glu465 470 475 480gac acc gat gta cag tcc gga tca ggt gtt gtg atc acc ggt tca atc 1488Asp Thr Asp Val Gln Ser Gly Ser Gly Val Val Ile Thr Gly Ser Ile

485 490 495gtg acc gcc ggc gat gcg cgc acg ctg ttt gga aag gaa cct gca 1533Val Thr Ala Gly Asp Ala Arg Thr Leu Phe Gly Lys Glu Pro Ala

500505510 tgagcaagcg tgaagaatca att 1556<210>698<211>511<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>698Gly Ile Gly Leu Val Ala Asn Asn Asp Gly Ile Phe Asp Ser Glu Asn 151015 Asp Asp Ile Thr Val Gly Asp Val Thr Leu Gly Glu Thr Gly Leu Ser

20 25 30Leu Pro Ile Asp Leu Ala Gly Glu Val Glu Ala Pro Ala Ser Glu Glu

35 40 45Ile Thr Gln Glu Asp Leu Leu Arg Leu Ala Gln Val Glu Ala Glu Leu

50 55 60Asp Gln Arg Trp Leu Glu Thr Lys Ile Asp Pro Thr Phe Arg Arg Met 65 70 75 80Ser Tyr Met Met Asp Leu Met Gly Gln Pro Gln Asn Ser Phe Pro Ala

85 90 95Ile His Val Ala Gly Thr Asn Gly Lys Thr Ser Thr Thr Arg Met Ile

100 105 110Glu Ser Leu Leu Arg Ala Phe His Arg Arg Thr Gly Arg Thr Thr Ser

115 120 125Pro His Leu Gln Leu Val Thr Glu Arg Ile Ala Ile Asp Gly Lys Pro

130 135 140Ile His Pro Arg Asp Phe Val Arg Ile Tyr Glu Glu Ile Lys Pro Tyr145 150155 160Met Glu Met Thr Asp Ala Trp Ser Glu Ala Glu Gly Gly Pro Lys Met

165 170 175Ser Lys Phe Glu Ala Leu Val Ala Leu Ala Tyr Ala Gly Phe Ala Asp

180 185 190Ala Pro Val Asp Val Ala Val Val Glu Val Gly Leu Gly Gly Arg Trp

195 200 205Asp Ala Thr Asn Val Ile Asn Ala Ala Val Ser Val Ile Thr Pro Val

210 215 220Gly Met Asp His Val Asp Arg Leu Gly Asn Thr Ile Gly Glu Ile Ala225 230 235 240Gly Glu Lys Ala Gly Ile Ile Lys Ala Arg Pro Ala Ser Glu Asp Gly

245 250 255Thr Glu Pro Glu Gly Asn Val Val Ile Val Gly Lys Gln Glu Pro Glu

260 265 270Ala Met Asn Val Ile Leu Gln Gln Ala Val Asp Val Asp Ala Ala Val

275 280 285Ala Arg Leu Asn Met Glu Phe Gly Val Val Glu Ser Ala Ile Ala Val

290 295 300Gly Gly Gln Gln Leu Thr Leu Lys Gly Leu Gly Gly Glu Tyr Thr Asp305 310 315 320Ile Phe Leu Pro Leu Ser Gly Ala His Gln Ala Asp Asn Ala Ala Val

325 330 335Ala Leu Ala Ala Val Glu Ala Phe Phe Gly Ala Ser Ala Gly Arg Pro

340 345 350Leu Asp Ile Asp Thr Val Arg Glu Gly Phe Ala Gln Val Gln Ser Pro

355 360 365Gly Arg Leu Glu Arg Leu Arg Ser Ala Pro Thr Val Phe Ile Asp Ala

370375 380Ala His Asn Pro His Gly Ala Ala Ala Leu Gly Ala Ala Leu Asp Arg385 390 395 400Asp Phe Glu Phe Arg Arg Leu Ile Gly Val Ile Gly Val Leu Cys Asp

405 410 415Lys Asp Ala Arg Gly Ile Leu Glu Ser Leu Glu Pro Tyr Leu His Glu

420 425 430Ile Val Cys Thr Gln Thr Ala Ser Glu Arg Ala Leu Asp Ala Tyr Asp

435 440 445Leu Ala Glu Tyr Ala Arg Glu Ile Tyr Gly Asp Glu Arg Val His Val

450 455 460Gln Glu Asp Leu Ala Gly Ala Val Glu Leu Ala Ile Glu Leu Ala Glu465 470 475 480Asp Thr Asp Val Gln Ser Gly Ser Gly Val Val Ile Thr Gly Ser Ile

485 490 495Val Thr Ala Gly Asp Ala Arg Thr Leu Phe Gly Lys Glu Pro Ala

500505510<210>699<211>600<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (577)<223>RXA01517<400>699tccataagcc caaagcaccg atcccacgta cttttgctga cgtcgcggtg gttgcccgac 60gttccaggaa atccatggct gctggaagga gcaacgccta atg cat gca gtt ttg 115

Met His Ala Val Leu

1 5tcc atc ggt tcc aac atg gat gat cgc tac gcg ctg ctc aac aca gtg 163Ser Ile Gly Ser Asn Met Asp Asp Arg Tyr Ala Leu Leu Asn Thr Val

10 15 20atc gag gaa ttc aaa gat gag atc gtg gcg cag tct gcg atc tac tca 211Ile Glu Glu Phe Lys Asp Glu Ile Val Ala Gln Ser Ala Ile Tyr Ser

25 30 35acc cca ccg tgg ggc att gag gat cag gat gaa ttc ctc aac gca gtg 259Thr Pro Pro Trp Gly Ile Glu Asp Gln Asp Glu Phe Leu Asn Ala Val

40 45 50ctc gtt gtt gag gtt gaa gaa acc ccc atc gag ttg ctg cgc cgt ggc 307Leu Val Val Glu Val Glu Glu Thr Pro Ile Glu Leu Leu Arg Arg Gly

55 60 65caa aaa ctc gaa gaa gcc gcc gag cgg gtc cgc gtc cgc aaa tgg ggg 355Gln Lys Leu Glu Glu Ala Ala Glu Arg Val Arg Val Arg Lys Trp Gly 70 75 80 85cca cgc acc ctc gat gtg gat atc gtg cag atc att aaa gat ggg gaa 403Pro Arg Thr Leu Asp Val Asp Ile Val Gln Ile Ile Lys Asp Gly Glu

90 95 100gag atc ctt tct gag gat ccc gaa ctg acc ttg cca cac cct tgg gct 451Glu Ile Leu Ser Glu Asp Pro Glu Leu Thr Leu Pro His Pro Trp Ala

105 110 115tgg cag cgt gcc ttc gtg ttg atc cct tgg ttg gaa gca gaa cct gat 499Trp Gln Arg Ala Phe Val Leu Ile Pro Trp Leu Glu Ala Glu Pro Asp

120 125 130gcc gtc ctg cac ggc acg acc att gca gaa cat gtg gat aat ctt gat 547Ala Val Leu His Gly Thr Thr Ile Ala Glu His Val Asp Asn Leu Asp

135140145 ccc aca gac att gaa ggt gtc acc aag att taaggagtcg tggctttcat 597Pro Thr Asp Ile Glu Gly Val Thr Lys Ile 150155 gca 600<210>700<211>159<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>700Met His Ala Val Leu Ser Ile Gly Ser Asn Met Asp Asp Arg Tyr Ala 151015 Leu Leu Asn Thr Val Ile Glu Glu Phe Lys Asp Glu Ile Val Ala Gln

2025 30Ser Ala Ile Tyr Ser Thr Pro Pro Trp Gly Ile Glu Asp Gln Asp Glu

35 40 45Phe Leu Asn Ala Val Leu Val Val Glu Val Glu Glu Thr Pro Ile Glu

50 55 60Leu Leu Arg Arg Gly Gln Lys Leu Glu Glu Ala Ala Glu Arg Val Arg 65 70 75 80Val Arg Lys Trp Gly Pro Arg Thr Leu Asp Val Asp Ile Val Gln Ile

85 90 95Ile Lys Asp Gly Glu Glu Ile Leu Ser Glu Asp Pro Glu Leu Thr Leu

100 105 110Pro His Pro Trp Ala Trp Gln Arg Ala Phe Val Leu Ile Pro Trp Leu

115 120 125Glu Ala Glu Pro Asp Ala Val Leu His Gly Thr Thr Ile Ala Glu His

130135140 Val Asp Asn Leu Asp Pro Thr Asp Ile Glu Gly Val Thr Lys Ile 145150155<210>701<211>1983<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1960)<223>RXA00579<400>701tcgtctaagt ttttctttga gttttcatat gtagaaggca tcgtcggctt cggcctggcg 60gtgcttttct cgttgttttg tggttttgtc agaggatgtc atg cgc gtt tta att 115

Met Arg Val Leu Ile

1 5att gat aat tat gat tct ttc acg ttt aat ctc gcc acc tat gtg gaa 163Ile Asp Asn Tyr Asp Ser Phe Thr Phe Asn Leu Ala Thr Tyr Val Glu

10 15 20gag gtt acg ggt cag gca cct gtg gtg gtg cct aat gat caa gaa ata 211Glu Val Thr Gly Gln Ala Pro Val Val Val Pro Asn Asp Gln Glu Ile

25 30 35gat gag atg ctt ttc gac gcc gtc atc ctc tca cct ggc ccg ggc cac 259Asp Glu Met Leu Phe Asp Ala Val Ile Leu Ser Pro Gly Pro Gly His

40 45 50gcc ggc gtt gcg gct gat ttt ggt atc tgt gca ggc gtc att gag cgt 307Ala Gly Val Ala Ala Asp Phe Gly Ile Cys Ala Gly Val Ile Glu Arg

55 60 65gca cgc gtt ccg att ttg ggt gtg tgt tta ggc cac cag ggc att gcg 355Ala Arg Val Pro Ile Leu Gly Val Cys Leu Gly His Gln Gly Ile Ala 70 75 80 85ttg gcc tat ggc ggt gat gtt gat ttg gcg ccc agg ccg gtc cac ggt 403Leu Ala Tyr Gly Gly Asp Val Asp Leu Ala Pro Arg Pro Val His Gly

90 95 100gag gtt tcg cag atc acc cat gat ggt tca ggt tta ttt gca ggc atc 451Glu Val Ser Gln Ile Thr His Asp Gly Ser Gly Leu Phe Ala Gly Ile

105 110 115cct gaa acg ttt gag gcg gtg cgt tat cac tcg atg gtg gca acc cgc 499Pro Glu Thr Phe Glu Ala Val Arg Tyr His Ser Met Val Ala Thr Arg

120 125 130ttg ccg gag tca ttg aaa gct aca gct acc agc gat gat ggt ttg atc 547Leu Pro Glu Ser Leu Lys Ala Thr Ala Thr Ser Asp Asp Gly Leu Ile

135 140 145atg gca ttg gca cat gaa gtg ctt ccg cag tgg ggt gtg caa ttt cat 595Met Ala Leu Ala His Glu Val Leu Pro Gln Trp Gly Val Gln Phe His150 155 160 165ccg gaa tct att ggt gga caa ttc ggc cat cag atc att aag aac ttc 643Pro Glu Ser Ile Gly Gly Gln Phe Gly His Gln Ile Ile Lys Asn Phe

170 175 180ctt aat tta gcg cgc aca tat cgc tgg caa ctc acg gag aaa act att 691Leu Asn Leu Ala Arg Thr Tyr Arg Trp Gln Leu Thr Glu Lys Thr Ile

185 190 195ccg ctc agc gtt gat tca gca gcg gtt ttt gaa aca ttc ttt gcc cat 739Pro Leu Ser Val Asp Set Ala Ala Val Phe Glu Thr Phe Phe Ala His

200 205 210tcc tcc cat gct ttt tgg ctc gat gat gcc caa gga acc agc tat ctt 787Ser Ser His Ala Phe Trp Leu Asp Asp Ala Gln Gly Thr Ser Tyr Leu

215 220 225ggt gat gcc agc ggt cct ctc gca cgc aca aaa acc cat aat gtc ggc 835Gly Asp Ala Ser Gly Pro Leu Ala Arg Thr Lys Thr His Asn Val Gly230 235 240 245gag ggg gat ttc ttc acc tgg cta aag gag gat ctc gcc gcc aac tca 883Glu Gly Asp Phe Phe Thr Trp Leu Lys Glu Asp Leu Ala Ala Asn Ser

250 255 260gtt gcg ccc ggt caa ggt ttt cgt ctt ggc tgg gtt ggt tac gtt ggt 931Val Ala Pro Gly Gln Gly Phe Arg Leu Gly Trp Val Gly Tyr Val Gly

265 270 275tat gag ctt aaa gcg gaa gct ggc gca cgg gct gcg cac act tcg agt 979Tyr Glu Leu Lys Ala Glu Ala Gly Ala Arg Ala Ala His Thr Ser Ser

280 285 290ctt ccg gat gcg cac ctc att ttt gcc gat cgc gcc atc gca gtg gaa 1027Leu Pro Asp Ala His Leu Ile Phe Ala Asp Arg Ala Ile Ala Val Glu

295 300 305tcg gat cag gtt cgg ttg ctg gcg ttg ggg gag cag gac gag tgg ttt 1075Ser Asp Gln Val Arg Leu Leu Ala Leu Gly Glu Gln Asp Glu Trp Phe310 315 320 325gaa gaa acc atc aag aag ctg cat aat ctt gtc gcc ccg cgg ata cct 1123Glu Glu Thr Ile Lys Lys Leu His Asn Leu Val Ala Pro Arg Ile Pro

330 335 340gcg tcc gga cac ctc gct ttg cag gtt cga gat tcc aaa gat gag tat 1171Ala Ser Gly His Leu Ala Leu Gln Val Arg Asp Ser Lys Asp Glu Tyr

345 350 355ctc gac aaa att cgc aga gcc cag gag ctg att act cgc ggc gaa tcg 1219Leu Asp Lys Ile Arg Arg Ala Gln Glu Leu Ile Thr Arg Gly Glu Ser

360 365 370tat gaa atc tgc ctg acc aca aaa ctt cag ggc acc act gat gtg gcc 1267Tyr Glu Ile Cys Leu Thr Thr Lys Leu Gln Gly Thr Thr Asp Val Ala

375 380 385cct ctg gct gcc tat cta gca ctg cgt ggg gcc aat ccc acc gca tat 1315Pro Leu Ala Ala Tyr Leu Ala Leu Arg Gly Ala Asn Pro Thr Ala Tyr390 395 400 405ggt gcg tat ctt cag ctg ggg gat acc tct att ttg agt tcc tcg ccg 1363Gly Ala Tyr Leu Gln Leu Gly Asp Thr Ser Ile Leu Ser Ser Ser Pro

410 415 420gag cgg ttc atc acc att gat tcg gca ggg tat gtg gaa tca aag ccc 1411Glu Arg Phe Ile Thr Ile Asp Ser Ala Gly Tyr Val Glu Ser Lys Pro

425 430 435att aaa ggc acc agg ccg cgt ggg cga aca gcg caa gaa gac caa gaa 1459Ile Lys Gly Thr Arg Pro Arg Gly Arg Thr Ala Gln Glu Asp Gln Glu

440 445 450atc att gct gag ctg cgc agt aat cct aaa gat cgt gca gaa aac ttg 1507Ile Ile Ala Glu Leu Arg Ser Asn Pro Lys Asp Arg Ala Glu Asn Leu

455 460 465atg atc gtg gat ttg gtc cgc aac gac tta gcc cgc ggc gct ttg ccc 1555Met Ile Val Asp Leu Val Arg Asn Asp Leu Ala Arg Gly Ala Leu Pro470 475 480 485acc aca gtt aaa aca tcc aag ctt ttc gac gtc gaa acc tacgcc aca 1603Thr Thr Val Lys Thr Ser Lys Leu Phe Asp Val Glu Thr Tyr Ala Thr

490 495 500gtc cac caa ctt gtc agc acc gtc tct gca gag ttg ggg cca cgc agt 1651Val His Gln Leu Val Ser Thr Val Ser Ala Glu Leu Gly Pro Arg Ser

505 510 515ccg att gag tgc gtg cgc gca gca ttc ccc ggt ggt tcg atg act ggt 1699Pro Ile Glu Cys Val Arg Ala Ala Phe Pro Gly Gly Ser Met Thr Gly

520 525 530gcc cca aag ctg cgc acc atg gag atc atc gat gag ctg gag gca gct 1747Ala Pro Lys Leu Arg Thr Met Glu Ile Ile Asp Glu Leu Glu Ala Ala

535 540 545cct cgc ggt att tac tca ggt ggc ttg gga tat ttt tcc ctc gac ggc 1795Pro Arg Gly Ile Tyr Ser Gly Gly Leu Gly Tyr Phe Ser Leu Asp Gly550 555 560 565gca gtt gat ctc tcc atg gtg atc aga act ctc gtc atc cag aac aat 1843Ala Val Asp Leu Ser Met Val Ile Arg Thr Leu Val Ile Gln Asn Asn

570 575 580cac gtg gag tac gga gtg ggc ggt gca ctt ctt gct ctg tct gat ccg 1891His Val Glu Tyr Gly Val Gly Gly Ala Leu Leu Ala Leu Ser Asp Pro

585 590 595gag gct gag tgg gag gaa atc cgc gtt aaa tca cgg cct ctg ctg aat 1939Glu Ala Glu Trp Glu Glu Ile Arg Val Lys Ser Arg Pro Leu Leu Asn

600 605 610ttg ttt ggg gtt gaa ttc cca tgacgtacct cgtgtgggac ggt 1983Leu Phe Gly Val Glu Phe Pro

615620<210>702<211>620<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>702Met Arg Val Leu Ile Ile Asp Asn Tyr Asp Ser Phe Thr Phe Asn Leu 151015 Ala Thr Tyr Val Glu Glu Val Thr Gly Gln Ala Pro Val Val Val Pro

20 25 30Asn Asp Gln Glu Ile Asp Glu Met Leu Phe Asp Ala Val Ile Leu Ser

35 40 45Pro Gly Pro Gly His Ala Gly Val Ala Ala Asp Phe Gly Ile Cys Ala

50 55 60Gly Val Ile Glu Arg Ala Arg Val Pro Ile Leu Gly Val Cys Leu Gly 65 70 75 80His Gln Gly Ile Ala Leu Ala Tyr Gly Gly Asp Val Asp Leu Ala Pro

85 90 95Arg Pro Val His Gly Glu Val Ser Gln Ile Thr His Asp Gly Ser Gly

100 105 110Leu Phe Ala Gly Ile Pro Glu Thr Phe Glu Ala Val Arg Tyr His Ser

115 120 125Met Val Ala Thr Arg Leu Pro Glu Ser Leu Lys Ala Thr Ala Thr Ser

130 135 140Asp Asp Gly Leu Ile Met Ala Leu Ala His Glu Val Leu Pro Gln Trp145 150 155 160Gly Val Gln Phe His Pro Glu Ser Ile Gly Gly Gln Phe Gly His Gln

165 170 175Ile Ile Lys Asn Phe Leu Asn Leu Ala Arg Thr Tyr Arg Trp Gln Leu

180 185 190Thr Glu Lys Thr Ile Pro Leu Ser Val Asp Ser Ala Ala Val Phe Glu

195 200 205Thr Phe Phe Ala His Ser Ser His Ala Phe Trp Leu Asp Asp Ala Gln

210 215 220Gly Thr Ser Tyr Leu Gly Asp Ala Ser Gly Pro Leu Ala Arg Thr Lys225 230 235240Thr His Asn Val Gly Glu Gly Asp Phe Phe Thr Trp Leu Lys Glu Asp

245 250 255Leu Ala Ala Asn Ser Val Ala Pro Gly Gln Gly Phe Arg Leu Gly Trp

260 265 270Val Gly Tyr Val Gly Tyr Glu Leu Lys Ala Glu Ala Gly Ala Arg Ala

275 280 285Ala His Thr Ser Ser Leu Pro Asp Ala His Leu Ile Phe Ala Asp Arg

290 295 300Ala Ile Ala Val Glu Ser Asp Gln Val Arg Leu Leu Ala Leu Gly Glu305 310 315 320Gln Asp Glu Trp Phe Glu Glu Thr Ile Lys Lys Leu His Asn Leu Val

325 330 335Ala Pro Arg Ile Pro Ala Ser Gly His Leu Ala Leu Gln Val Arg Asp

340 345 350Ser Lys Asp Glu Tyr Leu Asp Lys Ile Arg Arg Ala Gln Glu Leu Ile

355 360 365Thr Arg Gly Glu Ser Tyr Glu Ile Cys Leu Thr Thr Lys Leu Gln Gly

370 375 380Thr Thr Asp Val Ala Pro Leu Ala Ala Tyr Leu Ala Leu Arg Gly Ala385 390 395 400Asn Pro Thr Ala Tyr Gly Ala Tyr Leu Gln Leu Gly Asp Thr Ser Ile

405 410 415Leu Ser Ser Ser Pro Glu Arg Phe Ile Thr Ile Asp Ser Ala Gly Tyr

420 425 430Val Glu Ser Lys Pro Ile Lys Gly Thr Arg Pro Arg Gly Arg Thr Ala

435 440 445Gln Glu Asp Gln Glu Ile Ile Ala Glu Leu Arg Ser Asn Pro Lys Asp

450 455 460Arg Ala Glu Asn Leu Met Ile Val Asp Leu Val Arg Asn Asp Leu Ala465 470 475 480Arg Gly Ala Leu Pro Thr Thr Val Lys Thr Ser Lys Leu Phe Asp Val

485 490 495Glu Thr Tyr Ala Thr Val His Gln Leu Val Ser Thr Val Ser Ala Glu

500 505 510Leu Gly Pro Arg Ser Pro Ile Glu Cys Val Arg Ala Ala Phe Pro Gly

515 520 525Gly Ser Met Thr Gly Ala Pro Lys Leu Arg Thr Met Glu Ile Ile Asp

530 535 540Glu Leu Glu Ala Ala Pro Arg Gly Ile Tyr Ser Gly Gly Leu Gly Tyr545 550 555 560Phe Ser Leu Asp Gly Ala Val Asp Leu Ser Met Val Ile Arg Thr Leu

565 570 575Val Ile Gln Asn Asn His Val Glu Tyr Gly Val Gly Gly Ala Leu Leu

580 585 590Ala Leu Ser Asp Pro Glu Ala Glu Trp Glu Glu Ile Arg Val Lys Ser

595 600 605Arg Pro Leu Leu Asn Leu Phe Gly Val Glu Phe Pro

610615620<210>703<211>747<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (724)<223>RXA00958<400>703attctaatcc tcaatctgaa gccgatgaga cgttgcacaa ggcgtatgcc gtgttgaatg 60ccattgcgct tgctgctggt tccactttgg aggtcatccg atg aca cac gtt gtt 115

Met Thr His Val Val

1 5ctc att gat aat cac gat tct ttt gtc tac aac ctggtg gat gcg ttc 163Leu Ile Asp Asn His Asp Ser Phe Val Tyr Asn Leu Val Asp Ala Phe

10 15 20gcc gtg gcc ggt tat aag tgc acg gtg ttc cgc aat acg gtg cca gtg 211Ala Val Ala Gly Tyr Lys Cys Thr Val Phe Arg Asn Thr Val Pro Val

25 30 35gaa acc att ttg gca gcc aac ccg gac ctg atc tgc ctt tca cct gga 259Glu Thr Ile Leu Ala Ala Asn Pro Asp Leu Ile Cys Leu Ser Pro Gly

40 45 50cct ggt tac cct gcc gat gcg ggc aac atg atg gcg ctg atc gag cgc 307Pro Gly Tyr Pro Ala Asp Ala Gly Asn Met Met Ala Leu Ile Glu Arg

55 60 65aca ctc ggc cag att cct tta ctg ggt att tgc ctc ggc tac cag gca 355Thr Leu Gly Gln Ile Pro Leu Leu Gly Ile Cys Leu Gly Tyr Gln Ala 70 75 80 85ctc atc gaa tac cac ggc ggc aag gtt gag cct tgt ggc cct gtg cac 403Leu Ile Glu Tyr His Gly Gly Lys Val Glu Pro Cys Gly Pro Val His

90 95 100ggc acc acc gac aac atg atc ctt act gat gca ggt gtg cag agc cct 451Gly Thr Thr Asp Asn Met Ile Leu Thr Asp Ala Gly Val Gln Ser Pro

105 110 115gtt ttt gca ggt ctt gcc act gat gtt gag cct gat cat cca gaa atc 499Val Phe Ala Gly Leu Ala Thr Asp Val Glu Pro Asp His Pro Glu Ile

120 125 130cca ggc cgc aag gtt cca att ggc cgt tat cac tca ctg ggc tgc gtg 547Pro Gly Arg Lys Val Pro Ile Gly Arg Tyr His Ser Leu Gly Cys Val

135 140 145gtt gcc cca gac ggt att gaa tca cta ggt acc tgt tcc tcg gag att 595Val Ala Pro Asp Gly Ile Glu Ser Leu Gly Thr Cys Ser Ser Glu Ile150 155 160 165ggt gat gtc atc atg gcg gca cgc acc acc gat gga aag gcc att ggc 643Gly Asp Val Ile Met Ala Ala Arg Thr Thr Asp Gly Lys Ala Ile Gly

170 175 180ctg cag ttt cac cct gag tca gtg cta agc cca acg ggt cct gtc att 691Leu Gln Phe His Pro Glu Ser Val Leu Ser Pro Thr Gly Pro Val Ile

185 190 195ttg tcc cgc tgt gtc gaa cag ctt ctc gcgaac taataaaaaa aggatttgat 744Leu Ser Arg Cys Val Glu Gln Leu Leu Ala Asn

200205 tca 747<210>704<211>208<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>704Met Thr His Val Val Leu Ile Asp Asn His Asp Ser Phe Val Tyr Asn 151015 Leu Val Asp Ala Phe Ala Val Ala Gly Tyr Lys Cys Thr Val Phe Arg

20 25 30Asn Thr Val Pro Val Glu Thr Ile Leu Ala Ala Asn Pro Asp Leu Ile

35 40 45Cys Leu Ser Pro Gly Pro Gly Tyr Pro Ala Asp Ala Gly Asn Met Met

50 55 60Ala Leu Ile Glu Arg Thr Leu Gly Gln Ile Pro Leu Leu Gly Ile Cys 65 70 75 80Leu Gly Tyr Gln Ala Leu Ile Glu Tyr His Gly Gly Lys Val Glu Pro

85 90 95Cys Gly Pro Val His Gly Thr Thr Asp Asn Met Ile Leu Thr Asp Ala

100 105 110Gly Val Gln Ser Pro Val Phe Ala Gly Leu Ala Thr Asp Val Glu Pro

115 120 125Asp His Pro Glu Ile Pro Gly Arg Lys Val Pro Ile Gly Arg Tyr His

130 135 140Ser Leu Gly Cys Val Val Ala Pro Asp Gly Ile Glu Ser Leu Gly Thr145 150 155 160Cys Ser Ser Glu Ile Gly Asp Val Ile Met Ala Ala Arg Thr Thr Asp

165 170 175Gly Lys Ala Ile Gly Leu Gln Phe His Pro Glu Ser Val Leu Ser Pro

180 185 190Thr Gly Pro Val Ile Leu Ser Arg Cys Val Glu Gln Leu Leu Ala Asn

195200205<210>705<211>1266<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1243)<223>RXA02790<400>705tggatgctcg cacccgagcc cttgaaccac aatccacaga cacccaagat ttcgacgaga 60agggaaattt cccaggatga accaaatccg aaaccgccgg atg gag ccc gtc tac 115

Met Glu Pro Val Tyr

1 5gta aag cgc cgc caa cgg ttt att gcc gtg acg atc gct tca ctc atc 163Val Lys Arg Arg Gln Arg Phe Ile Ala Val Thr Ile Ala Ser Leu Ile

10 15 20ctc att atc ggt gcc atc atc tat atc ggt gta gcc acc tca aac cgg 211Leu Ile Ile Gly Ala Ile Ile Tyr Ile Gly Val Ala Thr Ser Asn Arg

25 30 35acg cca cat gac tat gaa ggc tcc gga aac ggt gtg gtt cag ctg gtc 259Thr Pro His Asp Tyr Glu Gly Ser Gly Asn Gly Val Val Gln Leu Val

40 45 50gaa atc cct gaa ggt tcc tcc ata tca gag ctc ggc cca gag ttg gaa 307Glu Ile Pro Glu Gly Ser Ser Ile Ser Glu Leu Gly Pro Glu Leu Glu

55 60 65gaa cga gat atc gtg gcc acc aac tca gcg ttc caa aca gcg gcc agc 355Glu Arg Asp Ile Val Ala Thr Asn Ser Ala Phe Gln Thr Ala Ala Ser 70 75 80 85aac aac ccc aac gcg ggt agt gta cag cca ggt ttc tac cgt ctg cag 403Asn Asn Pro Asn Ala Gly Ser Val Gln Pro Gly Phe Tyr Arg Leu Gln

90 95 100gaa caa atg aac gca gca gct gca gtg tcg gct ctg ctt gat cca gac 451Glu Gln Met Asn Ala Ala Ala Ala Val Ser Ala Leu Leu Asp Pro Asp

105 110 115aac cag gtt gat ctc ctc gac att cac ggc ggc gcc acc ttg atg gac 499Asn Gln Val Asp Leu Leu Asp Ile His Gly Gly Ala Thr Leu Met Asp

120 125 130gtc act gtt gtc ggc gga aac acc cgc gcg gga atc tac tcc cag atc 547Val Thr Val Val Gly Gly Asn Thr Arg Ala Gly Ile Tyr Ser Gln Ile

135 140 145gca gcc gtg acc tgc acc gaa ggc tcc gcc aac tgc atc acc gct gag 595Ala Ala Val Thr Cys Thr Glu Gly Ser Ala Asn Cys Ile Thr Ala Glu150 155 160 165gat ttg cag cag gtt gcc tcc acc gtg tcg cct gca gaa ttg ggt gtc 643Asp Leu Gln Gln Val Ala Ser Thr Val Ser Pro Ala Glu Leu Gly Val

170 175 180cca gat tgg gca atc gct gct gtg gaa gct cgc gga act gat cca aag 691Pro Asp Trp Ala Ile Ala Ala Val Glu Ala Arg Gly Thr Asp Pro Lys

185 190 195cgc ctc gaa ggc ctg atc atg cct ggc caa tac gtg gtg gat cca tcc 739Arg Leu Glu Gly Leu Ile Met Pro Gly Gln Tyr Val Val Asp Pro Ser

200 205 210aac gac gcc cag gga atc ctc acc gat ctg atc acg cga tca gca aac 787Asn Asp Ala Gln Gly Ile Leu Thr Asp Leu Ile Thr ArgSer Ala Asn

215 220 225cat ttc caa gaa acc gac atc acg ggc cgt gca gat gcc atc gga ctt 835His Phe Gln Glu Thr Asp Ile Thr Gly Arg Ala Asp Ala Ile Gly Leu230 235 240 245act cca tat gag ctg gtc acc gca gca tct tta atc gag cgc gaa gca 883Thr Pro Tyr Glu Leu Val Thr Ala Ala Ser Leu Ile Glu Arg Glu Ala

250 255 260cca gca gga gat ttt gat aag gtc gcc cgc gtc atc ttg aac cgt ctc 931Pro Ala Gly Asp Phe Asp Lys Val Ala Arg Val Ile Leu Asn Arg Leu

265 270 275gcc gag cca atg cag ctg caa ttc gac tcc acc gtc aac tac ggt ctg 979Ala Glu Pro Met Gln Leu Gln Phe Asp Ser Thr Val Asn Tyr Gly Leu

280 285 290tct gaa caa gaa gta gca acc acc gac gaa gac cgt cag acc gtc acc 1027Ser Glu Gln Glu Val Ala Thr Thr Asp Glu Asp Arg Gln Thr Val Thr

295 300 305cca tgg aac act tac gcc atg gac ggc ctg cca caa acc ccc atc gcc 1075Pro Trp Asn Thr Tyr Ala Met Asp Gly Leu Pro Gln Thr Pro Ile Ala310 315 320 325gca gta tcc acc gaa gca ctc caa gcc atg gaa aac cct gca gaa gga 1123Ala Val Ser Thr Glu Ala Leu Gln Ala Met Glu Asn Pro Ala Glu Gly

330 335 340aac tgg ctg tac ttt gtc acc atc gac acc gat gga acc acc gtg ttc 1171Asn Trp Leu Tyr Phe Val Thr Ile Asp Thr Asp Gly Thr Thr Val Phe

345 350 355aac gac acc ttc gaa gag cac gaa gcc gac att gag caa gct ttg aac 1219Asn Asp Thr Phe Glu Glu His Glu Ala Asp Ile Glu Gln Ala Leu Asn

360 365370agt ggc gtt cta gac agc aac cga taaggatcag cgaataaaat tgg 1266Ser Gly Val Leu Asp Ser Asn Arg

375380<210>706<211>381<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>706Met Glu Pro Val Tyr Val Lys Arg Arg Gln Arg Phe Ile Ala Val Thr 151015 Ile Ala Ser Leu Ile Leu Ile Ile Gly Ala Ile Ile Tyr Ile Gly Val

20 25 30Ala Thr Ser Asn Arg Thr Pro His Asp Tyr Glu Gly Ser Gly Asn Gly

35 40 45Val Val Gln Leu Val Glu Ile Pro Glu Gly Ser Ser Ile Ser Glu Leu

50 55 60Gly Pro Glu Leu Glu Glu Arg Asp Ile Val Ala Thr Asn Ser Ala Phe 65 70 75 80Gln Thr Ala Ala Ser Asn Asn Pro Asn Ala Gly Ser Val Gln Pro Gly

85 90 95Phe Tyr Arg Leu Gln Glu Gln Met Asn Ala Ala Ala Ala Val Ser Ala

100 105 110Leu Leu Asp Pro Asp Asn Gln Val Asp Leu Leu Asp Ile His Gly Gly

115 120 125Ala Thr Leu Met Asp Val Thr Val Val Gly Gly Asn Thr Arg Ala Gly

130 135 140Ile Tyr Ser Gln Ile Ala Ala Val Thr Cys Thr Glu Gly Ser Ala Asn145 150 155 160Cys Ile Thr Ala Glu Asp Leu Gln Gln Val Ala Ser Thr Val Ser Pro

165 170 175Ala Glu Leu Gly Val Pro Asp Trp Ala Ile Ala Ala Val Glu Ala Arg

180 185 190Gly Thr Asp Pro Lys Arg Leu Glu Gly Leu Ile Met Pro Gly Gln Tyr

195 200 205Val Val Asp Pro Ser Asn Asp Ala Gln Gly Ile Leu Thr Asp Leu Ile

210 215 220Thr Arg Ser Ala Asn His Phe Gln Glu Thr Asp Ile Thr Gly Arg Ala225 230 235 240Asp Ala Ile Gly Leu Thr Pro Tyr Glu Leu Val Thr Ala Ala Ser Leu

245 250 255Ile Glu Arg Glu Ala Pro Ala Gly Asp Phe Asp Lys Val Ala Arg Val

260 265 270Ile Leu Asn Arg Leu Ala Glu Pro Met Gln Leu Gln Phe Asp Ser Thr

275 280 285Val Asn Tyr Gly Leu Ser Glu Gln Glu Val Ala Thr Thr Asp Glu Asp

290 295 300Arg Gln Thr Val Thr Pro Trp Asn Thr Tyr Ala Met Asp Gly Leu Pro305 310 315 320Gln Thr Pro Ile Ala Ala Val Ser Thr Glu Ala Leu Gln Ala Met Glu

325 330 335Asn Pro Ala Glu Gly Asn Trp Leu Tyr Phe Val Thr Ile Asp Thr Asp

340 345 350Gly Thr Thr Val Phe Asn Asp Thr Phe Glu Glu His Glu Ala Asp Ile

355 360 365Glu Gln Ala Leu Asn Ser Gly Val Leu Asp Ser Asn Arg

370375380<210>707<211>579<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (556)<223>RXA00106<400>707tggagctcaa caaggcagcg tacatgtttg agtacagctt cgatgacatc accgtgtccg 60gctacgatcc acacccattg atccgcggca aggtcgccgt atg atc ggt gcg att 115

Met Ile Gly Ala Ile

1 5tgg gca caa ggc cgt gac ggc atc atc ggc gac ggc acc gac atg ccc 163Trp Ala Gln Gly Arg Asp Gly Ile Ile Gly Asp Gly Thr Asp Met Pro

10 15 20tgg cac atc ccg gaa gac ctc aaa cac ttc aag aaa acc acc atg ggc 211Trp His Ile Pro Glu Asp Leu Lys His Phe Lys Lys Thr Thr Met Gly

25 30 35cag ccg gtc atc atg ggt cgt cgc acg tgg gag tct ttg ccg ttc aag 259Gln Pro Val Ile Met Gly Arg Arg Thr Trp Glu Ser Leu Pro Phe Lys

40 45 50ccg ctt ccc ggc cgc gag aac ttc att ctc tcc tca cgc gag ccc ggc 307Pro Leu Pro Gly Arg Glu Asn Phe Ile Leu Ser Ser Arg Glu Pro Gly

55 60 65gac tgg tcc gcc ggc ggc aca gtg gtc acc gaa atc cct aaa agc ggc 355Asp Trp Ser Ala Gly Gly Thr Val Val Thr Glu Ile Pro Lys Ser Gly 70 75 80 85tgg atc atg ggc ggc ggc gag gtc tac aag gcc acc gtc ggc agc gcc 403Trp Ile Met Gly Gly Gly Glu ValTyr Lys Ala Thr Val Gly Ser Ala

90 95 100gac gtt tta gaa ata acg ctt atc gac gcc acc ttc gat gtt tcc act 451Asp Val Leu Glu Ile Thr Leu Ile Asp Ala Thr Phe Asp Val Ser Thr

105 110 115ccc gtc tac gca ccc gaa atc ccg gcg aac ttc aac ctc gat gac gaa 499Pro Val Tyr Ala Pro Glu Ile Pro Ala Asn Phe Asn Leu Asp Asp Glu

120 125 130tcc gag tgg ttt acc tca ggc gag tat cgt tac aag ttc cag cgc tac 547Ser Glu Trp Phe Thr Ser Gly Glu Tyr Arg Tyr Lys Phe Gln Arg Tyr

135140145 atc aag gtt taaggagcaa acaacatgag caa 579Ile Lys Val150<210>708<211>152<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>708Met Ile Gly Ala Ile Trp Ala Gln Gly Arg Asp Gly Ile Ile Gly Asp 151015 Gly Thr Asp Met Pro Trp His Ile Pro Glu Asp Leu Lys His Phe Lys

20 25 30Lys Thr Thr Met Gly Gln Pro Val Ile Met Gly Arg Arg Thr Trp Glu

35 40 45Ser Leu Pro Phe Lys Pro Leu Pro Gly Arg Glu Asn Phe Ile Leu Ser

50 55 60Ser Arg Glu Pro Gly Asp Trp Ser Ala Gly Gly Thr Val Val Thr Glu 65 70 75 80Ile Pro Lys Ser Gly Trp Ile Met Gly Gly Gly Glu Val Tyr Lys Ala

85 90 95Thr Val Gly Ser Ala Asp Val Leu Glu Ile Thr Leu Ile Asp Ala Thr

100 105 110Phe Asp Val Ser Thr Pro Val Tyr Ala Pro Glu Ile Pro Ala Asn Phe

115 120 125Asn Leu Asp Asp Glu Ser Glu Trp Phe Thr Ser Gly Glu Tyr Arg Tyr

130135140 Lys Phe Gln Arg Tyr Ile Lys Val 145150<210>709<211>2599<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220>CDS<222>(101). (2599)<223>RXN02198<400>709agactagtgg cgctttgcct gtgttgctta ggcggcgttg aaaatgaact acgaatgaaa 60agttcgggaa ttgtctaatc cgtactaagc tgtctacaca atg tct act tca gtt 115

Met Ser Thr Ser Val

1 5act tca cca gcc cac aac aac gca cat tcc tcc gaa ttt ttg gat gcg 163Thr Ser Pro Ala His Asn Asn Ala His Ser Ser Glu Phe Leu Asp Ala

10 15 20ttg gca aac cat gtg ttg atc ggc gac ggc gcc atg ggc acc cag ctc 211Leu Ala Asn His Val Leu Ile Gly Asp Gly Ala Met Gly Thr Gln Leu

25 30 35caa ggc ttt gac ctg gac gtg gaa aag gat ttc ctt gat ctg gag ggg 259Gln Gly Phe Asp Leu Asp Val Glu Lys Asp Phe Leu Asp Leu Glu Gly

40 45 50tgt aat gag att ctc aac gac acc cgc cct gat gtg ttg agg cag att 307Cys Asn Glu Ile Leu Asn Asp Thr Arg Pro Asp Val Leu Arg Gln Ile

55 60 65cac cgc gcc tac ttt gag gcg gga gct gac ttg gtt gag acc aat act 355His Arg Ala Tyr Phe Glu Ala Gly Ala Asp Leu Val Glu Thr Asn Thr 70 75 80 85ttt ggt tgc aac ctg ccg aac ttg gcg gat tat gac atc gct gat cgt 403Phe Gly Cys Asn Leu Pro Asn Leu Ala Asp Tyr Asp Ile Ala Asp Arg

90 95 100tgc cgt gag ctt gcc tac aag ggc act gca gtg gct agg gaa gtg gct 451Cys Arg Glu Leu Ala Tyr Lys Gly Thr Ala Val Ala Arg Glu Val Ala

105 110 115gat gag atg ggg ccg ggc cga aac ggc atg cgg cgt ttc gtg gtt ggt 499Asp Glu Met Gly Pro Gly Arg Asn Gly Met Arg Arg Phe Val Val Gly

120 125 130tcc ctg gga cct gga acg aag ctt cca tcg ctg ggc cat gca ccg tat 547Ser Leu Gly Pro Gly Thr Lys Leu Pro Ser Leu Gly His Ala Pro Tyr

135 140 145gca gat ttg cgt ggg cac tac aag gaa gca gcg ctt ggc atc atc gac 595Ala Asp Leu Arg Gly His Tyr LysGlu Ala Ala Leu Gly Ile Ile Asp150 155 160 165ggt ggt ggc gat gcc ttt ttg att gag act gct cag gac ttg ctt cag 643Gly Gly Gly Asp Ala Phe Leu Ile Glu Thr Ala Gln Asp Leu Leu Gln

170 175 180gtc aag gct gcg gtt cac ggc gtt caa gat gcc atg gct gaa ctt gat 691Val Lys Ala Ala Val His Gly Val Gln Asp Ala Met Ala Glu Leu Asp

185 190 195aca ttc ttg ccc att att tgc cac gtc acc gta gag acc acc ggc acc 739Thr Phe Leu Pro Ile Ile Cys His Val Thr Val Glu Thr Thr Gly Thr

200 205 210atg ctc atg ggt tct gag atc ggt gcc gcg ttg aca gcg ctg cag cca 787Met Leu Met Gly Ser Glu Ile Gly Ala Ala Leu Thr Ala Leu Gln Pro

215 220 225ctg ggt atc gac atg att ggt ctg aac tgc gcc acc ggc cca gat gag 835Leu Gly Ile Asp Met Ile Gly Leu Asn Cys Ala Thr Gly Pro Asp Glu230 235 240 245atg agc gag cac ctg cgt tac ctg tcc aag cac gcc gat att cct gtg 883Met Ser Glu His Leu Arg Tyr Leu Ser Lys His Ala Asp Ile Pro Val

250 255 260tcg gtg atg cct aac gca ggt ctt cct gtc ctg ggt aaa aac ggt gca 931Ser Val Met Pro Asn Ala Gly Leu Pro Val Leu Gly Lys Asn Gly Ala

265 270 275gaa tac cca ctt gag gct gag gat ttg gcg cag gcg ctg gct gga ttc 979Glu Tyr Pro Leu Glu Ala Glu Asp Leu Ala Gln Ala Leu Ala Gly Phe

280 285 290gtc tcc gaa tat ggc ctg tcc atg gtg ggt ggt tgt tgt ggc acc aca 1027Val Ser Glu Tyr Gly Leu Ser Met Val Gly Gly Cys Cys Gly Thr Thr

295 300 305cct gag cac atc cgt gcg gtc cgc gat gcg gtg gtt ggt gtt cca gag 1075Pro Glu His Ile Arg Ala Val Arg Asp Ala Val Val Gly Val Pro Glu310 315 320 325cag gaa acc tcc aca ctg acc aag atc cct gca ggc cct gtt gag cag 1123Gln Glu Thr Ser Thr Leu Thr Lys Ile Pro Ala Gly Pro Val Glu Gln

330 335 340gcc tcc cgc gag gtg gag aaa gag gac tcc gtc gcg tcg ctg tac acc 1171Ala Ser Arg Glu Val Glu Lys Glu Asp Ser Val Ala Ser Leu Tyr Thr

345 350 355tcg gtg cca ttg tcc cag gaa acc ggc att tcc atg atc ggt gag cgc 1219Ser Val Pro Leu Ser Gln Glu Thr Gly Ile Ser Met Ile Gly Glu Arg

360 365 370acc aac tcc aac ggt tcc aag gca ttc cgt gag gca atg ctg tct ggc 1267Thr Asn Ser Asn Gly Ser Lys Ala Phe Arg Glu Ala Met Leu Ser Gly

375 380 385gat tgg gaa aag tgt gtg gat att gcc aag cag caa acc cgc gat ggt 1315Asp Trp Glu Lys Cys Val Asp Ile Ala Lys Gln Gln Thr Arg Asp Gly390 395 400 405gca cac atg ctg gat ctt tgt gtg gat tac gtg gga cga gac ggc acc 1363Ala His Met Leu Asp Leu Cys Val Asp Tyr Val Gly Arg Asp Gly Thr

410 415 420gcc gat atg gcg acc ttg gca gca ctt ctt gct acc agc tcc act ttg 1411Ala Asp Met Ala Thr Leu Ala Ala Leu Leu Ala Thr Ser Ser Thr Leu

425 430 435cca atc atg att gac tcc acc gag cca gag gtt att cgc aca ggc ctt 1459Pro Ile Met Ile Asp Ser Thr Glu Pro Glu Val Ile Arg Thr Gly Leu

440 445 450gag cac ttg ggt gga cga agc atc gtt aac tcc gtc aac ttt gaa gac 1507Glu His Leu Gly GlyArg Ser Ile Val Asn Ser Val Asn Phe Glu Asp

455 460 465ggc gat ggc cct gag tcc cgc tac cag cgc atc atg aaa ctg gta aag 1555Gly Asp Gly Pro Glu Ser Arg Tyr Gln Arg Ile Met Lys Leu Val Lys470 475 480 485cag cac ggt gcg gcc gtg gtt gcg ctg acc att gat gag gaa ggc cag 1603Gln His Gly Ala Ala Val Val Ala Leu Thr Ile Asp Glu Glu Gly Gln

490 495 500gca cgt acc gct gag cac aag gtg cgc att gct aaa cga ctg att gac 1651Ala Arg Thr Ala Glu His Lys Val Arg Ile Ala Lys Arg Leu Ile Asp

505 510 515gat atc acc ggc agc tac ggc ctg gat atc aaa gac atc gtt gtg gac 1699Asp Ile Thr Gly Ser Tyr Gly Leu Asp Ile Lys Asp Ile Val Val Asp

520 525 530tgc ctg acc ttc ccg atc tct act ggc cag gaa gaa acc agg cga gat 1747Cys Leu Thr Phe Pro Ile Ser Thr Gly Gln Glu Glu Thr Arg Arg Asp

535 540 545ggc att gaa acc atc gaa gcc atc cgc gag ctg aag aag ctc tac cca 1795Gly Ile Glu Thr Ile Glu Ala Ile Arg Glu Leu Lys Lys Leu Tyr Pro550 555 560 565gaa atc cac acc acc ctg ggt ctg tcc aat att tcc ttc ggc ctg aac 1843Glu Ile His Thr Thr Leu Gly Leu Ser Asn Ile Ser Phe Gly Leu Asn

570 575 580cct gct gca cgc cag gtt ctt aac tct gtg ttc ctc aat gag tgc att 1891Pro Ala Ala Arg Gln Val Leu Asn Ser Val Phe Leu Asn Glu Cys Ile

585 590 595gag gct ggt ctg gac tct gcg att gcg cac agc tcc aag att ttg ccg 1939Glu Ala Gly Leu Asp Ser Ala Ile Ala His Ser Ser Lys Ile Leu Pro

600 605 610atg aac cgc att gat gat cgc cag cgc gaa gtg gcg ttg gat atg gtc 1987Met Asn Arg Ile Asp Asp Arg Gln Arg Glu Val Ala Leu Asp Met Val

615 620 625tat gat cgc cgc acc gag gat tac gat ccg ctg cag gaa ttc atg cag 2035Tyr Asp Arg Arg Thr Glu Asp Tyr Asp Pro Leu Gln Glu Phe Met Gln630 635 640 645ctg ttt gag ggc gtt tct gct gcc gat gcc aag gat gct cgc gct gaa 2083Leu Phe Glu Gly Val Ser Ala Ala Asp Ala Lys Asp Ala Arg Ala Glu

650 655 660cag ctg gcc gct atg cct ttg ttt gag cgt ttg gca cag cgc atc atc 2131Gln Leu Ala Ala Met Pro Leu Phe Glu Arg Leu Ala Gln Arg Ile Ile

665 670 675gac ggc gat aag aat ggc ctt gag gat gat ctg gaa gca ggc atg aag 2179Asp Gly Asp Lys Asn Gly Leu Glu Asp Asp Leu Glu Ala Gly Met Lys

680 685 690gag aag tct cct att gcg atc atc aac gag gac ctt ctc aac ggc atg 2227Glu Lys Ser Pro Ile Ala Ile Ile Asn Glu Asp Leu Leu Asn Gly Met

695 700 705aag acc gtg ggt gag ctg ttt ggt tcc gga cag atg cag ctg cca ttc 2275Lys Thr Val Gly Glu Leu Phe Gly Ser Gly Gln Met Gln Leu Pro Phe710 715 720 725gtg ctg caa tcg gca gaa acc atg aaa act gcg gtg gcc tat ttg gaa 2323Val Leu Gln Ser Ala Glu Thr Met Lys Thr Ala Val Ala Tyr Leu Glu

730 735 740ccg ttc atg gaa gag gaa gca gaa gct acc gga tct gcg cag gca gag 2371Pro Phe Met Glu Glu Glu Ala Glu Ala Thr Gly Ser Ala Gln Ala Glu

745 750 755ggc aag ggc aaa atc gtc gtg gcc acc gtc aag ggtgac gtg cac gat 2419Gly Lys Gly Lys Ile Val Val Ala Thr Val Lys Gly Asp Val His Asp

760 765 770atc ggc aag aac ttg gtg gac atc att ttg tcc aac aac ggt tac gac 2467Ile Gly Lys Asn Leu Val Asp Ile Ile Leu Ser Asn Asn Gly Tyr Asp

775 780 785gtg gtg aac ttg ggc atc aag cag cca ctg tcc gcc atg ttg gaa gca 2515Val Val Asn Leu Gly Ile Lys Gln Pro Leu Ser Ala Met Leu Glu Ala790 795 800 805gcg gaa gaa cac aaa gca gac gtc atc ggc atg tcg gga ctt ctt gtg 2563Ala Glu Glu His Lys Ala Asp Val Ile Gly Met Ser Gly Leu Leu Val

810 815 820aag tcc acc gtg gtg atg aag caa acc atc agc gac 2599Lys Ser Thr Val Val Met Lys Gln Thr Ile Ser Asp

825830<210>710<211>833<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>710Met Ser Thr Ser Val Thr Ser Pro Ala His Asn Asn Ala His Ser Ser 151015 Glu Phe Leu Asp Ala Leu Ala Asn His Val Leu Ile Gly Asp Gly Ala

20 25 30Met Gly Thr Gln Leu Gln Gly Phe Asp Leu Asp Val Glu Lys Asp Phe

35 40 45Leu Asp Leu Glu Gly Cys Asn Glu Ile Leu Asn Asp Thr Arg Pro Asp

50 55 60Val Leu Arg Gln Ile His Arg Ala Tyr Phe Glu Ala Gly Ala Asp Leu 65 70 75 80Val Glu Thr Asn Thr Phe Gly Cys Asn Leu Pro Asn Leu Ala Asp Tyr

85 90 95Asp Ile Ala Asp Arg Cys Arg Glu Leu Ala Tyr Lys Gly Thr Ala Val

100 105 110Ala Arg Glu Val Ala Asp Glu Met Gly Pro Gly Arg Asn Gly Met Arg

115 120 125Arg Phe Val Val Gly Ser Leu Gly Pro Gly Thr Lys Leu Pro Ser Leu

130 135 140Gly His Ala Pro Tyr Ala Asp Leu Arg Gly His Tyr Lys Glu Ala Ala145 150 155 160Leu Gly Ile Ile Asp Gly Gly Gly Asp Ala Phe Leu Ile Glu Thr Ala

165 170 175Gln Asp Leu Leu Gln Val Lys Ala Ala Val His Gly Val Gln Asp Ala

180 185 190Met Ala Glu Leu Asp Thr Phe Leu Pro Ile Ile Cys His Val Thr Val

195 200 205Glu Thr Thr Gly Thr Met Leu Met Gly Ser Glu Ile Gly Ala Ala Leu

210 215 220Thr Ala Leu Gln Pro Leu Gly Ile Asp Met Ile Gly Leu Asn Cys Ala225 230 235 240Thr Gly Pro Asp Glu Met Ser Glu His Leu Arg Tyr Leu Ser Lys His

245 250 255Ala Asp Ile Pro Val Ser Val Met Pro Asn Ala Gly Leu Pro Val Leu

260 265 270Gly Lys Asn Gly Ala Glu Tyr Pro Leu Glu Ala Glu Asp Leu Ala Gln

275 280 285Ala Leu Ala Gly Phe Val Ser Glu Tyr Gly Leu Ser Met Val Gly Gly

290 295 300Cys Cys Gly Thr Thr Pro Glu His Ile Arg Ala Val Arg Asp Ala Val305 310 315 320Val Gly Val Pro Glu Gln Glu Thr Ser Thr Leu Thr Lys Ile Pro Ala

325330 335Gly Pro Val Glu Gln Ala Ser Arg Glu Val Glu Lys Glu Asp Ser Val

340 345 350Ala Ser Leu Tyr Thr Ser Val Pro Leu Ser Gln Glu Thr Gly Ile Ser

355 360 365Met Ile Gly Glu Arg Thr Asn Ser Asn Gly Ser Lys Ala Phe Arg Glu

370 375 380Ala Met Leu Ser Gly Asp Trp Glu Lys Cys Val Asp Ile Ala Lys Gln385 390 395 400 Gln Thr Arg Asp Gly Ala His Met Leu Asp Leu Cys Val Asp Tyr Val

405 410 415Gly Arg Asp Gly Thr Ala Asp Met Ala Thr Leu Ala Ala Leu Leu Ala

420 425 430Thr Ser Ser Thr Leu Pro Ile Met Ile Asp Ser Thr Glu Pro Glu Val

435 440 445Ile Arg Thr Gly Leu Glu His Leu Gly Gly Arg Ser Ile Val Asn Ser

450 455 460Val Asn Phe Glu Asp Gly Asp Gly Pro Glu Ser Arg Tyr Gln Arg Ile465 470 475 480Met Lys Leu Val Lys Gln His Gly Ala Ala Val Val Ala Leu Thr Ile

485 490 495Asp Glu Glu Gly Gln Ala Arg Thr Ala Glu His Lys Val Arg Ile Ala

500 505 510Lys Arg Leu Ile Asp Asp Ile Thr Gly Ser Tyr Gly Leu Asp Ile Lys

515 520 525Asp Ile Val Val Asp Cys Leu Thr Phe Pro Ile Ser Thr Gly Gln Glu

530 535 540Glu Thr Arg Arg Asp Gly Ile Glu Thr Ile Glu Ala Ile Arg Glu Leu545 550555 560Lys Lys Leu Tyr Pro Glu Ile His Thr Thr Leu Gly Leu Ser Asn Ile

565 570 575Ser Phe Gly Leu Asn Pro Ala Ala Arg Gln Val Leu Asn Ser Val Phe

580 585 590Leu Asn Glu Cys Ile Glu Ala Gly Leu Asp Ser Ala Ile Ala His Ser

595 600 605Ser Lys Ile Leu Pro Met Asn Arg Ile Asp Asp Arg Gln Arg Glu Val

610 615 620Ala Leu Asp Met Val Tyr Asp Arg Arg Thr Glu Asp Tyr Asp Pro Leu625 630 635 640Gln Glu Phe Met Gln Leu Phe Glu Gly Val Ser Ala Ala Asp Ala Lys

645 650 655Asp Ala Arg Ala Glu Gln Leu Ala Ala Met Pro Leu Phe Glu Arg Leu

660 665 670Ala Gln Arg Ile Ile Asp Gly Asp Lys Asn Gly Leu Glu Asp Asp Leu

675 680 685Glu Ala Gly Met Lys Glu Lys Ser Pro Ile Ala Ile Ile Asn Glu Asp

690 695 700Leu Leu Asn Gly Met Lys Thr Val Gly Glu Leu Phe Gly Ser Gly Gln705 710 715 720Met Gln Leu Pro Phe Val Leu Gln Ser Ala Glu Thr Met Lys Thr Ala

725 730 735ValAla Tyr Leu Glu Pro Phe Met Glu Glu Glu Ala Glu Ala Thr Gly

740 745 750Ser Ala Gln Ala Glu Gly Lys Gly Lys Ile Val Val Ala Thr Val Lys

755 760 765Gly Asp Val His Asp Ile Gly Lys Asn Leu Val Asp Ile Ile Leu Ser

770 775 780Asn Asn Gly Tyr Asp Val Val Asn Leu Gly Ile Lys Gln Pro Leu Ser785 790 795 800Ala Met Leu Glu Ala Ala Glu Glu His Lys Ala Asp Val Ile Gly Met

805 810 815Ser Gly Leu Leu Val Lys Ser Thr Val Val Met Lys Gln Thr Ile Ser

820825830 Asp<210>711<211>2578<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (2578)<223>FRXA02198<400>711agactagtgg cgctttgcct gtgttgctta ggcggcgttg aaaatgaact acgaatgaaa 60agttcgggaa ttgtctaatc cgtactaagc tgtctacaca atg tct act tca gtt 115

Met Ser Thr Ser Val

1 5act tca cca gcc cac aac aac gca cat tcc tcc gaa ttt ttg gat gcg 163Thr Ser Pro Ala His Asn Asn Ala His Ser Ser Glu Phe Leu Asp Ala

10 15 20ttg gca aac cat gtg ttg atc ggc gac ggc gcc atg ggc acc cag ctc 211Leu Ala Asn His Val Leu Ile Gly Asp Gly Ala Met Gly Thr Gln Leu

25 30 35caa ggc ttt gac ctg gac gtg gaa aag gat ttc ctt gat ctg gag ggg 259Gln Gly Phe Asp Leu Asp Val Glu Lys Asp Phe Leu Asp Leu Glu Gly

40 45 50tgt aat gag att ctc aac gac acc cgc cct gat gtg ttg agg cag att 307Cys Asn Glu Ile Leu Asn Asp Thr Arg Pro Asp Val Leu Arg Gln Ile

55 60 65cac cgc gcc tac ttt gag gcg gga gct gac ttg gtt gag acc aat act 355His Arg Ala Tyr Phe Glu Ala Gly Ala Asp Leu Val Glu Thr Asn Thr 70 7580 85ttt ggt tgc aac ctg ccg aac ttg gcg gat tat gac atc gct gat cgt 403Phe Gly Cys Asn Leu Pro Asn Leu Ala Asp Tyr Asp Ile Ala Asp Arg

90 95 100tgc cgt gag ctt gcc tac aag ggc act gca gtg gct agg gaa gtg gct 451Cys Arg Glu Leu Ala Tyr Lys Gly Thr Ala Val Ala Arg Glu Val Ala

105 110 115gat gag atg ggg ccg ggc cga aac ggc atg cgg cgt ttc gtg gtt ggt 499Asp Glu Met Gly Pro Gly Arg Asn Gly Met Arg Arg Phe Val Val Gly

120 125 130tcc ctg gga cct gga acg aag ctt cca tcg ctg ggc cat gca ccg tat 547Ser Leu Gly Pro Gly Thr Lys Leu Pro Ser Leu Gly His Ala Pro Tyr

135 140 145gca gat ttg cgt ggg cac tac aag gaa gca gcg ctt ggc atc atc gac 595Ala Asp Leu Arg Gly His Tyr Lys Glu Ala Ala Leu Gly Ile Ile Asp150 155 160 165ggt ggt ggc gat gcc ttt ttg att gag act gct cag gac ttg ctt cag 643Gly Gly Gly Asp Ala Phe Leu Ile Glu Thr Ala Gln Asp Leu Leu Gln

170 175 180gtc aag gct gcg gtt cac ggc gtt caa gat gcc atg gct gaa ctt gat 691Val Lys Ala Ala Val His Gly Val Gln Asp Ala Met Ala Glu Leu Asp

185 190 195aca ttc ttg ccc att att tgc cac gtc acc gta gag acc acc ggc acc 739Thr Phe Leu Pro Ile Ile Cys His Val Thr Val Glu Thr Thr Gly Thr

200 205 210atg ctc atg ggt tct gag atc ggt gcc gcg ttg aca gcg ctg cag cca 787Met Leu Met Gly Ser Glu Ile Gly Ala Ala Leu Thr Ala Leu Gln Pro

215 220 225ctg ggt atc gac atg att ggt ctg aactgc gcc acc ggc cca gat gag 835Leu Gly Ile Asp Met Ile Gly Leu Asn Cys Ala Thr Gly Pro Asp Glu230 235 240 245atg agc gag cac ctg cgt tac ctg tcc aag cac gcc gat att cct gtg 883Met Ser Glu His Leu Arg Tyr Leu Ser Lys His Ala Asp Ile Pro Val

250 255 260tcg gtg atg cct aac gca ggt ctt cct gtc ctg ggt aaa aac ggt gca 931Ser Val Met Pro Asn Ala Gly Leu Pro Val Leu Gly Lys Asn Gly Ala

265 270 275gaa tac cca ctt gag gct gag gat ttg gcg cag gcg ctg gct gga ttc 979Glu Tyr Pro Leu Glu Ala Glu Asp Leu Ala Gln Ala Leu Ala Gly Phe

280 285 290gtc tcc gaa tat ggc ctg tcc atg gtg ggt ggt tgt tgt ggc acc aca 1027Val Ser Glu Tyr Gly Leu Ser Met Val Gly Gly Cys Cys Gly Thr Thr

295 300 305cct gag cac atc cgt gcg gtc cgc gat gcg gtg gtt ggt gtt cca gag 1075Pro Glu His Ile Arg Ala Val Arg Asp Ala Val Val Gly Val Pro Glu310 315 320 325cag gaa acc tcc aca ctg acc aag atc cct gca ggc cct gtt gag cag 1123Gln Glu Thr Ser Thr Leu Thr Lys Ile Pro Ala Gly Pro Val Glu Gln

330 335 340gcc tcc cgc gag gtg gag aaa gag gac tcc gtc gcg tcg ctg tac acc 1171Ala Ser Arg Glu Val Glu Lys Glu Asp Ser Val Ala Ser Leu Tyr Thr

345 350 355tcg gtg cca ttg tcc cag gaa acc ggc att tcc atg atc ggt gag cgc 1219Ser Val Pro Leu Ser Gln Glu Thr Gly Ile Ser Met Ile Gly Glu Arg

360 365 370acc aac tcc aac ggt tcc aag gca ttc cgt gag gca atg ctg tct ggc 1267Thr Asn Ser Asn Gly Ser Lys Ala Phe Arg Glu Ala Met Leu Ser Gly

375 380 385gat tgg gaa aag tgt gtg gat att gcc aag cag caa acc cgc gat ggt 1315Asp Trp Glu Lys Cys Val Asp Ile Ala Lys Gln Gln Thr Arg Asp Gly390 395 400 405gca cac atg ctg gat ctt tgt gtg gat tac gtg gga cga gac ggc acc 1363Ala His Met Leu Asp Leu Cys Val Asp Tyr Val Gly Arg Asp Gly Thr

410 415 420gcc gat atg gcg acc ttg gca gca ctt ctt gct acc agc tcc act ttg 1411Ala Asp Met Ala Thr Leu Ala Ala Leu Leu Ala Thr Ser Ser Thr Leu

425 430 435cca atc atg att gac tcc acc gag cca gag gtt att cgc aca ggc ctt 1459Pro Ile Met Ile Asp Ser Thr Glu Pro Glu Val Ile Arg Thr Gly Leu

440 445 450gag cac ttg ggt gga cga agc atc gtt aac tcc gtc aac ttt gaa gac 1507Glu His Leu Gly Gly Arg Ser Ile Val Asn Ser Val Asn Phe Glu Asp

455 460 465ggc gat ggc cct gag tcc cgc tac cag cgc atc atg aaa ctg gta aag 1555Gly Asp Gly Pro Glu Ser Arg Tyr Gln Arg Ile Met Lys Leu Val Lys470 475 480 485cag cac ggt gcg gcc gtg gtt gcg ctg acc att gat gag gaa ggc cag 1603Gln His Gly Ala Ala Val Val Ala Leu Thr Ile Asp Glu Glu Gly Gln

490 495 500gca cgt acc gct gag cac aag gtg cgc att gct aaa cga ctg att gac 1651Ala Arg Thr Ala Glu His Lys Val Arg Ile Ala Lys Arg Leu Ile Asp

505 510 515gat atc acc ggc agc tac ggc ctg gat atc aaa gac atc gtt gtg gac 1699Asp Ile Thr Gly Ser Tyr Gly Leu Asp Ile Lys Asp Ile Val Val Asp

520 525530tgc ctg acc ttc ccg atc tct act ggc cag gaa gaa acc agg cga gat 1747Cys Leu Thr Phe Pro Ile Ser Thr Gly Gln Glu Glu Thr Arg Arg Asp

535 540 545ggc att gaa acc atc gaa gcc atc cgc gag ctg aag aag ctc tac cca 1795Gly Ile Glu Thr Ile Glu Ala Ile Arg Glu Leu Lys Lys Leu Tyr Pro550 555 560 565gaa atc cac acc acc ctg ggt ctg tcc aat att tcc ttc ggc ctg aac 1843Glu Ile His Thr Thr Leu Gly Leu Ser Asn Ile Ser Phe Gly Leu Asn

570 575 580cct gct gca cgc cag gtt ctt aac tct gtg ttc ctc aat gag tgc att 1891Pro Ala Ala Arg Gln Val Leu Asn Ser Val Phe Leu Asn Glu Cys Ile

585 590 595gag gct ggt ctg gac tct gcg att gcg cac agc tcc aag att ttg ccg 1939Glu Ala Gly Leu Asp Ser Ala Ile Ala His Ser Ser Lys Ile Leu Pro

600 605 610atg aac cgc att gat gat cgc cag cgc gaa gtg gcg ttg gat atg gtc 1987Met Asn Arg Ile Asp Asp Arg Gln Arg Glu Val Ala Leu Asp Met Val

615 620 625tat gat cgc cgc acc gag gat tac gat ccg ctg cag gaa ttc atg cag 2035Tyr Asp Arg Arg Thr Glu Asp Tyr Asp Pro Leu Gln Glu Phe Met Gln630 635 640 645ctg ttt gag ggc gtt tct gct gcc gat gcc aag gat gct cgc gct gaa 2083Leu Phe Glu Gly Val Ser Ala Ala Asp Ala Lys Asp Ala Arg Ala Glu

650 655 660cag ctg gcc gct atg cct ttg ttt gag cgt ttg gca cag cgc atc atc 2131Gln Leu Ala Ala Met Pro Leu Phe Glu Arg Leu Ala Gln Arg Ile Ile

665 670 675gac ggc gat aag aat ggc ctt gag gat gat ctg gaa gca ggc atg aag 2179Asp Gly AspLys Asn Gly Leu Glu Asp Asp Leu Glu Ala Gly Met Lys

680 685 690gag aag tct cct att gcg atc atc aac gag gac ctt ctc aac ggc atg 2227Glu Lys Ser Pro Ile Ala Ile Ile Asn Glu Asp Leu Leu Asn Gly Met

695 700 705aag acc gtg ggt gag ctg ttt ggt tcc gga cag atg cag ctg cca ttc 2275Lys Thr Val Gly Glu Leu Phe Gly Ser Gly Gln Met Gln Leu Pro Phe710 715 720 725gtg ctg caa tcg gca gaa acc atg aaa act gcg gtg gcc tat ttg gaa 2323Val Leu Gln Ser Ala Glu Thr Met Lys Thr Ala Val Ala Tyr Leu Glu

730 735 740ccg ttc atg gaa gag gaa gca gaa gct acc gga tct gcg cag gca gag 2371Pro Phe Met Glu Glu Glu Ala Glu Ala Thr Gly Ser Ala Gln Ala Glu

745 750 755ggc aag ggc aaa atc gtc gtg gcc acc gtc aag ggt gac gtg cac gat 2419Gly Lys Gly Lys Ile Val Val Ala Thr Val Lys Gly Asp Val His Asp

760 765 770atc ggc aag aac ttg gtg gac atc att ttg tcc aac aac ggt tac gac 2467Ile Gly Lys Asn Leu Val Asp Ile Ile Leu Ser Asn Asn Gly Tyr Asp

775 780 785gtg gtg aac ttg ggc atc aag cag cca ctg tcc gcc atg ttg gaa gca 2515Val Val Asn Leu Gly Ile Lys Gln Pro Leu Ser Ala Met Leu Glu Ala790 795 800 805gcg gaa gaa cac aaa gca gac gtc atc ggc atg tcg gga ctt ctt gtg 2563Ala Glu Glu His Lys Ala Asp Val Ile Gly Met Ser Gly Leu Leu Val

810 815 820aag tcc acc gtg gtg 2578Lys Ser Thr Val Val

825<210>712<211>826<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>712Met Ser Thr Ser Val Thr Ser Pro Ala His Asn Asn Ala His Ser Ser 151015 Glu Phe Leu Asp Ala Leu Ala Asn His Val Leu Ile Gly Asp Gly Ala

20 25 30Met Gly Thr Gln Leu Gln Gly Phe Asp Leu Asp Val Glu Lys Asp Phe

35 40 45Leu Asp Leu Glu Gly Cys Asn Glu Ile Leu Asn Asp Thr Arg Pro Asp

50 55 60Val Leu Arg Gln Ile His Arg Ala Tyr Phe Glu Ala Gly Ala Asp Leu 65 70 75 80Val Glu Thr Asn Thr Phe Gly Cys Asn Leu Pro Asn Leu Ala Asp Tyr

85 90 95Asp Ile Ala Asp Arg Cys Arg Glu Leu Ala Tyr Lys Gly Thr Ala Val

100 105 110Ala Arg Glu Val Ala Asp Glu Met Gly Pro Gly Arg Asn Gly Met Arg

115 120 125Arg Phe Val Val Gly Ser Leu Gly Pro Gly Thr Lys Leu Pro Ser Leu

130 135 140Gly His Ala Pro Tyr Ala Asp Leu Arg Gly His Tyr Lys Glu Ala Ala145 150 155 160Leu Gly Ile Ile Asp Gly Gly Gly Asp Ala Phe Leu Ile Glu Thr Ala

165 170 175Gln Asp Leu Leu Gln Val Lys Ala Ala Val His Gly Val Gln Asp Ala

180 185 190Met Ala Glu Leu Asp Thr Phe Leu Pro Ile Ile Cys His Val Thr Val

195 200 205Glu Thr Thr Gly Thr Met Leu Met Gly Ser Glu Ile Gly Ala Ala Leu

210 215 220Thr Ala Leu Gln Pro Leu Gly Ile Asp Met Ile Gly Leu Asn Cys Ala225 230 235 240Thr Gly Pro Asp Glu Met Ser Glu His Leu Arg Tyr Leu Ser Lys His

245 250 255Ala Asp Ile Pro Val Ser Val Met Pro Asn Ala Gly Leu Pro Val Leu

260 265 270Gly Lys Asn Gly Ala Glu Tyr Pro Leu Glu Ala Glu Asp Leu Ala Gln

275 280 285Ala Leu Ala Gly Phe Val Ser Glu Tyr Gly Leu Ser Met Val Gly Gly

290 295 300Cys Cys Gly Thr Thr Pro Glu His Ile Arg Ala Val Arg Asp Ala Val305 310 315 320Val Gly Val Pro Glu Gln Glu Thr Ser Thr Leu Thr Lys Ile Pro Ala

325 330 335Gly Pro Val Glu Gln Ala Ser Arg Glu Val Glu Lys Glu Asp Ser Val

340 345 350Ala Ser Leu Tyr Thr Ser Val Pro Leu Ser Gln Glu Thr Gly Ile Ser

355 360 365Met Ile Gly Glu Arg Thr Asn Ser Asn Gly Ser Lys Ala Phe Arg Glu

370 375 380Ala Met Leu Ser Gly Asp Trp Glu Lys Cys Val Asp Ile Ala Lys Gln385 390 395 400Gln Thr Arg Asp Gly Ala His Met Leu Asp Leu Cys Val Asp Tyr Val

405 410 415Gly Arg Asp Gly Thr Ala Asp Met Ala Thr Leu Ala Ala Leu Leu Ala

420 425 430Thr Ser Ser Thr Leu Pro Ile Met Ile Asp Ser Thr Glu Pro Glu Val

435 440445Ile Arg Thr Gly Leu Glu His Leu Gly Gly Arg Ser Ile Val Asn Ser

450 455 460Val Asn Phe Glu Asp Gly Asp Gly Pro Glu Ser Arg Tyr Gln Arg Ile465 470 475 480Met Lys Leu Val Lys Gln His Gly Ala Ala Val Val Ala Leu Thr Ile

485 490 495Asp Glu Glu Gly Gln Ala Arg Thr Ala Glu His Lys Val Arg Ile Ala

500 505 510Lys Arg Leu Ile Asp Asp Ile Thr Gly Ser Tyr Gly Leu Asp Ile Lys

515 520 525Asp Ile Val Val Asp Cys Leu Thr Phe Pro Ile Ser Thr Gly Gln Glu

530 535 540Glu Thr Arg Arg Asp Gly Ile Glu Thr Ile Glu Ala Ile Arg Glu Leu545 550 555 560Lys Lys Leu Tyr Pro Glu Ile His Thr Thr Leu Gly Leu Ser Asn Ile

565 570 575Ser Phe Gly Leu Asn Pro Ala Ala Arg Gln Val Leu Asn Ser Val Phe

580 585 590Leu Asn Glu Cys Ile Glu Ala Gly Leu Asp Ser Ala Ile Ala His Ser

595 600 605Ser Lys Ile Leu Pro Met Asn Arg Ile Asp Asp Arg Gln Arg Glu Val

610 615 620Ala Leu Asp Met Val Tyr Asp Arg Arg Thr Glu Asp Tyr Asp Pro Leu625 630 635 640Gln Glu Phe Met Gln Leu Phe Glu Gly Val Ser Ala Ala Asp Ala Lys

645 650 655Asp Ala Arg Ala Glu Gln Leu Ala Ala Met Pro Leu Phe Glu Arg Leu

660 665 670Ala Gln Arg Ile Ile Asp Gly Asp Lys Asn Gly Leu Glu Asp Asp Leu

675 680 685Glu Ala Gly Met Lys Glu Lys Ser Pro Ile Ala Ile Ile Asn Glu Asp

690 695 700Leu Leu Asn Gly Met Lys Thr Val Gly Glu Leu Phe Gly Ser Gly Gln705 710 715 720Met Gln Leu Pro Phe Val Leu Gln Ser Ala Glu Thr Met Lys Thr Ala

725 730 735Val Ala Tyr Leu Glu Pro Phe Met Glu Glu Glu Ala Glu Ala Thr Gly

740 745 750Ser Ala Gln Ala Glu Gly Lys Gly Lys Ile Val Val Ala Thr Val Lys

755 760 765Gly Asp Val His Asp Ile Gly Lys Asn Leu Val Asp Ile Ile Leu Ser

770 775 780Asn Asn Gly Tyr Asp Val Val Asn Leu Gly Ile Lys Gln Pro Leu Ser785 790 795 800Ala Met Leu Glu Ala Ala Glu Glu His Lys Ala Asp Val Ile Gly Met

805 810 815Ser Gly Leu Leu Val Lys Ser Thr Val Val

820825<210>713<211>2358<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (2335)<223>RXN02085<400>713cacccggtga tttcgcgaac cttgaaacat cgtcagaaga ttgccgtgcg tcctagccgg 60gatccgcacg ttcggctcaa gcagaaagtc tttaactcac atg act tcc aac ttt 115

Met Thr Ser Asn Phe

1 5tct tcc act gtc gct ggt ctt cct cgc atc gga gcg aagcgt gaa ctg 163Ser Ser Thr Val Ala Gly Leu Pro Arg Ile Gly Ala Lys Arg Glu Leu

10 15 20aag ttc gcg ctc gaa ggc tac tgg aat gga tca att gaa ggt cgc gaa 211Lys Phe Ala Leu Glu Gly Tyr Trp Asn Gly Ser Ile Glu Gly Arg Glu

25 30 35ctt gcg cag acc gcc cgc caa ttg gtc aac act gca tcg gat tct ttg 259Leu Ala Gln Thr Ala Arg Gln Leu Val Asn Thr Ala Ser Asp Ser Leu

40 45 50tct gga ttg gat tcc gtt ccg ttt gca gga cgt tcc tac tac gac gca 307Ser Gly Leu Asp Ser Val Pro Phe Ala Gly Arg Ser Tyr Tyr Asp Ala

55 60 65atg ctc gat acc gcc gct att ttg ggt gtg ctg ccg gag cgt ttt gat 355Met Leu Asp Thr Ala Ala Ile Leu Gly Val Leu Pro Glu Arg Phe Asp 70 75 80 85gac atc gct gat cat gaa aac gat ggt ctc cca ctg tgg att gac cgc 403Asp Ile Ala Asp His Glu Asn Asp Gly Leu Pro Leu Trp Ile Asp Arg

90 95 100tac ttt ggc gct gct cgc ggt act gag acc ctg cct gca cag gca atg 451Tyr Phe Gly Ala Ala Arg Gly Thr Glu Thr Leu Pro Ala Gln Ala Met

105 110 115acc aag tgg ttt gat acc aac tac cac tac ctc gtg ccg gag ttg tct 499Thr Lys Trp Phe Asp Thr Asn Tyr His Tyr Leu Val Pro Glu Leu Ser

120 125 130gcg gat aca cgt ttc gtt ttg gat gcg tcc gcg ctg att gag gat ctc 547Ala Asp Thr Arg Phe Val Leu Asp Ala Ser Ala Leu Ile Glu Asp Leu

135 140 145cgt tgc cag cag gtt cgt ggc gtt aat gcc cgc cct gtt ctg gtt ggt 595Arg Cys Gln Gln Val Arg Gly Val Asn Ala Arg Pro Val Leu Val Gly150 155 160 165cca ctg act ttc ctt tcc ctt gct cgc acc act gat ggt tcc aat cct 643Pro Leu Thr Phe Leu Ser Leu Ala Arg Thr Thr Asp Gly Ser Asn Pro

170 175 180ttg gat cac ctg cct gca ctg ttt gag gtc tac gag cgc ctc atc aag 691Leu Asp His Leu Pro Ala Leu Phe Glu Val Tyr Glu Arg Leu Ile Lys

185 190 195tct ttc gat act gag tgg gtt cag atc gat gag cct gcg ttg gtc acc 739Ser Phe Asp Thr Glu Trp Val Gln Ile Asp Glu Pro Ala Leu Val Thr

200 205 210gat gtt gct cct gag gtt ttg gag cag gtc cgc gct ggt tac acc act 787Asp Val Ala Pro Glu Val Leu Glu Gln Val Arg Ala Gly Tyr Thr Thr

215 220 225ttg gct aag cgc gat ggc gtg ttt gtc aat act tac ttc ggc tct ggc 835Leu Ala Lys Arg Asp Gly Val Phe Val Asn Thr Tyr Phe Gly Ser Gly230 235 240 245gat cag gcg ctg aac act ctt gcg ggc atc ggc ctt ggc gcg att ggc 883Asp Gln Ala Leu Asn Thr Leu Ala Gly Ile Gly Leu Gly Ala Ile Gly

250 255 260gtt gac ttg gtc acc cat ggc gtc act gag ctt gct gcg tgg aag ggt 931Val Asp Leu Val Thr His Gly Val Thr Glu Leu Ala Ala Trp Lys Gly

265 270 275gag gag ctg ctg gtt gcg ggc atc gtt gat ggt cgt aac att tgg cgc 979Glu Glu Leu Leu Val Ala Gly Ile Val Asp Gly Arg Asn Ile Trp Arg

280 285 290acc gac ctg tgt gct gct ctt gct tcc ctg aag cgc ctg gca gct cgc 1027Thr Asp Leu Cys Ala Ala Leu Ala Ser Leu Lys Arg Leu Ala Ala Arg

295 300 305ggc cca atc gca gtg tct acc tct tgt tca ctg ctg cac gtt cct tac 1075Gly Pro Ile Ala Val Ser Thr Ser Cys Ser Leu Leu His Val Pro Tyr310 315 320 325acc ctc gag gct gag aac att gag cct gag gtc cgc gac tgg ctt gcc 1123Thr Leu Glu Ala Glu Asn Ile Glu Pro Glu Val Arg Asp Trp Leu Ala

330 335 340ttc ggc tcg gag aag atc acc gag gtc aag ctg ctt gcc gac gcc cta 1171Phe Gly Ser Glu Lys Ile Thr Glu Val Lys Leu Leu Ala Asp Ala Leu

345 350 355gcc ggc aac atc gac gcg gct gcg ttc gat gcg gcg tcc gca gca att 1219Ala Gly Asn Ile Asp Ala Ala Ala Phe Asp Ala Ala Ser Ala Ala Ile

360 365 370gct tct cga cgc acc tcc cca cgc acc gca cca atc acg cag gaa ctc 1267Ala Ser Arg Arg Thr Ser Pro Arg Thr Ala Pro Ile Thr Gln Glu Leu

375 380 385cct ggc cgt agc cgt gga tcc ttc gac act cgt gtt acg ctg cag gag 1315Pro Gly Arg Ser Arg Gly Ser Phe Asp Thr Arg Val Thr Leu Gln Glu390 395 400 405aag tca ctg gag ctt cca gct ctg cca acc acc acc att ggt tct ttc 1363Lys Ser Leu Glu Leu Pro Ala Leu Pro Thr Thr Thr Ile Gly Ser Phe

410 415 420cca cag acc cca tcc att cgt tct gct cgc gct cgt ctg cgc aag gaa 1411Pro Gln Thr Pro Ser Ile Arg Ser Ala Arg Ala Arg Leu Arg Lys Glu

425 430 435tcc atc act ttg gag cag tac gaa gag gca atg cgc gaa gaa atc gat 1459Ser Ile Thr Leu Glu Gln Tyr Glu Glu Ala Met Arg Glu Glu Ile Asp

440 445 450ctg gtc atc gcc aag cag gaa gaa ctt ggt ctt gat gtg ttg gtt cac 1507Leu Val Ile Ala Lys Gln Glu Glu Leu Gly Leu AspVal Leu Val His

455 460 465ggt gag cca gag cgc aac gac atg gtt cag tac ttc tct gaa ctt ctc 1555Gly Glu Pro Glu Arg Asn Asp Met Val Gln Tyr Phe Ser Glu Leu Leu470 475 480 485gac ggt ttc ctc tca acc gcc aac ggc tgg gtc caa agc tac ggc tcc 1603Asp Gly Phe Leu Ser Thr Ala Asn Gly Trp Val Gln Ser Tyr Gly Ser

490 495 500cgc tgt gtt cgt cct cca gtg ttg ttc gga aac gtt tcc cgc cca gcg 1651Arg Cys Val Arg Pro Pro Val Leu Phe Gly Asn Val Ser Arg Pro Ala

505 510 515cca atg act gtc aag tgg ttc cag tac gca cag agc ctg acc cag aag 1699Pro Met Thr Val Lys Trp Phe Gln Tyr Ala Gln Ser Leu Thr Gln Lys

520 525 530cat gtc aag gga atg ctc acc ggt cca gtc acc atc ctt gca tgg tcc 1747His Val Lys Gly Met Leu Thr Gly Pro Val Thr Ile Leu Ala Trp Ser

535 540 545ttc gtt cgc gat gat cag ccg ctg gct acc act gct gac cag gtt gca 1795Phe Val Arg Asp Asp Gln Pro Leu Ala Thr Thr Ala Asp Gln Val Ala550 555 560 565ctg gca ctg cgc gat gaa att aac gat ctc atc gag gct ggc gcg aag 1843Leu Ala Leu Arg Asp Glu Ile Asn Asp Leu Ile Glu Ala Gly Ala Lys

570 575 580atc atc cag gtg gat gag cct gcg att cgt gaa ctg ttg ccg cta cga 1891Ile Ile Gln Val Asp Glu Pro Ala Ile Arg Glu Leu Leu Pro Leu Arg

585 590 595gac gtc gat aag cct gcc tac ctg cag tgg tcc gtg gac tcc ttc cgc 1939Asp Val Asp Lys Pro Ala Tyr Leu Gln Trp Ser Val Asp Ser Phe Arg

600 605610ctg gcg act gcc ggc gca ccc gac gac gtc caa atc cac acc cac atg 1987Leu Ala Thr Ala Gly Ala Pro Asp Asp Val Gln Ile His Thr His Met

615 620 625tgc tac tcc gag ttc aac gaa gtg atc tcc tcg gtc atc gcg ttg gat 2035Cys Tyr Ser Glu Phe Asn Glu Val Ile Ser Ser Val Ile Ala Leu Asp630 635 640 645gcc gat gtc acc acc atc gaa gca gca cgt tcc gac atg cag gtc ctc 2083Ala Asp Val Thr Thr Ile Glu Ala Ala Arg Ser Asp Met Gln Val Leu

650 655 660gct gct ctg aaa tct tcc ggc ttc gag ctc ggc gtc gga cct ggt gtg 2131Ala Ala Leu Lys Ser Ser Gly Phe Glu Leu Gly Val Gly Pro Gly Val

665 670 675tgg gat atc cac tcc ccg cgc gtt cct tcc gcg cag aaa gtg gac ggt 2179Trp Asp Ile His Ser Pro Arg Val Pro Ser Ala Gln Lys Val Asp Gly

680 685 690ctc ctc gag gct gca ctg cag tcc gtg gat cct cgc cag ctg tgg gtc 2227Leu Leu Glu Ala Ala Leu Gln Ser Val Asp Pro Arg Gln Leu Trp Val

695 700 705aac cca gac tgt ggt ctg aag acc cgt gga tgg cca gaa gtg gaa gct 2275Asn Pro Asp Cys Gly Leu Lys Thr Arg Gly Trp Pro Glu Val Glu Ala710 715 720 725tcc cta aag gtt ctc gtt gag tcc gct aag cag gct cgt gag aaa atc 2323Ser Leu Lys Val Leu Val Glu Ser Ala Lys Gln Ala Arg Glu Lys Ile

730 735 740gga gca act atc taaattgggt taccgctagg aac 2358Gly Ala Thr Ile

745<210>714<211>745<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>714Met Thr Ser Asn Phe Ser Ser Thr Val Ala Gly Leu Pro Arg Ile Gly 151015 Ala Lys Arg Glu Leu Lys Phe Ala Leu Glu Gly Tyr Trp Asn Gly Ser

20 25 30Ile Glu Gly Arg Glu Leu Ala Gln Thr Ala Arg Gln Leu Val Asn Thr

35 40 45Ala Ser Asp Ser Leu Ser Gly Leu Asp Ser Val Pro Phe Ala Gly Arg

50 55 60Ser Tyr Tyr Asp Ala Met Leu Asp Thr Ala Ala Ile Leu Gly Val Leu 65 70 75 80Pro Glu Arg Phe Asp Asp Ile Ala Asp His Glu Asn Asp Gly Leu Pro

85 90 95Leu Trp Ile Asp Arg Tyr Phe Gly Ala Ala Arg Gly Thr Glu Thr Leu

100 105 110Pro Ala Gln Ala Met Thr Lys Trp Phe Asp Thr Asn Tyr His Tyr Leu

115 120 125Val Pro Glu Leu Ser Ala Asp Thr Arg Phe Val Leu Asp Ala Ser Ala

130 135 140Leu Ile Glu Asp Leu Arg Cys Gln Gln Val Arg Gly Val Asn Ala Arg145 150 155 160Pro Val Leu Val Gly Pro Leu Thr Phe Leu Ser Leu Ala Arg Thr Thr

165 170 175Asp Gly Ser Asn Pro Leu Asp His Leu Pro Ala Leu Phe Glu Val Tyr

180 185 190Glu Arg Leu Ile Lys Ser Phe Asp Thr Glu Trp Val Gln Ile Asp Glu

195 200 205Pro Ala Leu Val Thr Asp Val Ala Pro Glu Val Leu Glu Gln Val Arg

210 215 220Ala Gly Tyr Thr Thr Leu Ala Lys Arg Asp Gly Val Phe Val Asn Thr225 230235 240Tyr Phe Gly Ser Gly Asp Gln Ala Leu Asn Thr Leu Ala Gly Ile Gly

245 250 255Leu Gly Ala Ile Gly Val Asp Leu Val Thr His Gly Val Thr Glu Leu

260 265 270Ala Ala Trp Lys Gly Glu Glu Leu Leu Val Ala Gly Ile Val Asp Gly

275 280 285Arg Asn Ile Trp Arg Thr Asp Leu Cys Ala Ala Leu Ala Ser Leu Lys

290 295 300Arg Leu Ala Ala Arg Gly Pro Ile Ala Val Ser Thr Ser Cys Ser Leu305 310 315 320Leu His Val Pro Tyr Thr Leu Glu Ala Glu Asn Ile Glu Pro Glu Val

325 330 335Arg Asp Trp Leu Ala Phe Gly Ser Glu Lys Ile Thr Glu Val Lys Leu

340 345 350Leu Ala Asp Ala Leu Ala Gly Asn Ile Asp Ala Ala Ala Phe Asp Ala

355 360 365Ala Ser Ala Ala Ile Ala Ser Arg Arg Thr Ser Pro Arg Thr Ala Pro

370 375 380Ile Thr Gln Glu Leu Pro Gly Arg Ser Arg Gly Ser Phe Asp Thr Arg385 390 395 400Val Thr Leu Gln Glu Lys Ser Leu Glu Leu Pro Ala Leu Pro Thr Thr

405 410 415Thr Ile Gly Ser Phe Pro Gln Thr Pro Ser Ile Arg Ser Ala Arg Ala

420 425 430Arg Leu Arg Lys Glu Ser Ile Thr Leu Glu Gln Tyr Glu Glu Ala Met

435 440 445Arg Glu Glu Ile Asp Leu Val Ile Ala Lys Gln Glu Glu Leu Gly Leu

450 455 460Asp Val Leu Val His Gly Glu Pro Glu Arg Asn Asp Met Val Gln Tyr465 470 475 480Phe Ser Glu Leu Leu Asp Gly Phe Leu Ser Thr Ala Asn Gly Trp Val

485 490 495Gln Ser Tyr Gly Ser Arg Cys Val Arg Pro Pro Val Leu Phe Gly Asn

500 505 510Val Ser Arg Pro Ala Pro Met Thr Val Lys Trp Phe Gln Tyr Ala Gln

515 520 525Ser Leu Thr Gln Lys His Val Lys Gly Met Leu Thr Gly Pro Val Thr

530 535 540Ile Leu Ala Trp Ser Phe Val Arg Asp Asp Gln Pro Leu Ala Thr Thr545 550 555 560Ala Asp Gln Val Ala Leu Ala Leu Arg Asp Glu Ile Asn Asp Leu Ile

565 570 575Glu Ala Gly Ala Lys Ile Ile Gln Val Asp Glu Pro Ala Ile Arg Glu

580 585 590Leu Leu Pro Leu Arg Asp Val Asp Lys Pro Ala Tyr Leu Gln Trp Ser

595 600 605Val Asp Ser Phe Arg Leu Ala Thr Ala Gly Ala Pro Asp Asp Val Gln

610 615 620Ile His Thr His Met Cys Tyr Ser Glu Phe Asn Glu Val Ile Ser Ser625 630 635 640Val Ile Ala Leu Asp Ala Asp Val Thr Thr Ile Glu Ala Ala Arg Ser

645 650 655Asp Met Gln Val Leu Ala Ala Leu Lys Ser Ser Gly Phe Glu Leu Gly

660 665 670Val Gly Pro Gly Val Trp Asp Ile His Ser Pro Arg Val Pro Ser Ala

675 680 685Gln Lys Val Asp Gly Leu Leu Glu Ala Ala Leu Gln Ser Val Asp Pro

690 695 700Arg Gln Leu Trp Val Asn Pro Asp Cys Gly Leu Lys Thr Arg Gly Trp705 710 715 720Pro Glu Val Glu Ala Ser Leu Lys Val Leu Val Glu Ser Ala Lys Gln

725 730 735Ala Arg Glu Lys Ile Gly Ala Thr Ile

740745<210>715<211>1923<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1900)<223>FRXA02085<400>715cacccggtga tttcgcgaac cttgaaacat cgtcagaaga ttgccgtgcg tcctagccgg 60gatccgcacg ttcggctcaa gcagaaagtc tttaactcac atg act tcc aac ttt 115

Met Thr Ser Asn Phe

1 5tct tcc act gtc gct ggt ctt cct cgc atc gga gcg aag cgt gaa ctg 163Ser Ser Thr Val Ala Gly Leu Pro Arg Ile Gly Ala Lys Arg Glu Leu

10 15 20aag ttc gcg ctc gaa ggc tac tgg aat gga tca att gaa ggt cgc gaa 211Lys Phe Ala Leu Glu Gly Tyr Trp Asn Gly Ser Ile Glu Gly Arg Glu

25 30 35ctt gcg cag acc gcc cgc caa ttg gtc aac act gca tcg gat tct ttg 259Leu Ala Gln Thr Ala Arg Gln Leu Val Asn Thr Ala Ser Asp Ser Leu

40 45 50tct gga ttg gat tcc gtt ccg ttt gca gga cgt tcc tac tac gac gca 307Ser Gly Leu Asp Ser Val Pro Phe Ala Gly Arg Ser Tyr Tyr Asp Ala

55 60 65atg ctc gat acc gcc gct att ttg ggt gtg ctg ccg gag cgt ttt gat 355Met Leu Asp Thr Ala Ala Ile Leu Gly Val Leu Pro Glu Arg Phe Asp 70 75 80 85gac atc gct gat cat gaa aac gat ggt ctc cca ctg tgg att gac cgc 403Asp Ile Ala Asp His Glu Asn Asp Gly Leu Pro Leu Trp Ile Asp Arg

90 95 100tac ttt ggc gct gct cgc ggt act gag acc ctg cct gca cag gca atg 451Tyr Phe Gly Ala Ala Arg Gly Thr Glu Thr Leu Pro Ala Gln Ala Met

105 110 115acc aag tgg ttt gat acc aac tac cac tac ctc gtg ccg gag ttg tct 499Thr Lys Trp Phe Asp Thr Asn Tyr His Tyr Leu Val Pro Glu Leu Ser

120 125 130gcg gat aca cgt ttc gtt ttg gat gcg tcc gcg ctg att gag gat ctc 547Ala Asp Thr Arg Phe Val Leu Asp Ala Ser Ala Leu Ile Glu Asp Leu

135 140 145cgt tgc cag cag gtt cgt ggc gtt aat gcc cgc cct gtt ctg gtt ggt 595Arg Cys Gln Gln Val Arg Gly Val Asn Ala Arg Pro Val Leu Val Gly150 155 160 165cca ctg act ttc ctt tcc ctt gct cgc acc act gat ggt tcc aat cct 643Pro Leu Thr Phe Leu Ser Leu Ala Arg Thr Thr Asp Gly Ser Asn Pro

170 175 180ttg gat cac ctg cct gca ctg ttt gag gtc tac gag cgc ctc atc aag 691Leu Asp His Leu Pro Ala Leu Phe Glu Val Tyr Glu Arg Leu Ile Lys

185 190 195tct ttc gat act gag tgg gtt cag atc gat gag cct gcg ttg gtc acc 739Ser Phe Asp Thr Glu Trp Val Gln Ile Asp Glu Pro Ala Leu Val Thr

200 205 210gat gtt gct cct gag gtt ttg gag cag gtc cgc gct ggt tac acc act 787Asp Val Ala Pro Glu Val Leu Glu Gln Val Arg Ala Gly Tyr Thr Thr

215 220 225ttg gct aag cgc gat ggc gtg ttt gtc aat act tac ttc ggc tct ggc 835Leu Ala Lys Arg Asp Gly Val Phe Val Asn Thr Tyr Phe Gly Ser Gly230 235 240 245gat cag gcg ctg aac act ctt gcg ggc atc ggc ctt ggc gcg att ggc 883Asp Gln Ala Leu Asn Thr Leu Ala Gly Ile Gly Leu Gly Ala Ile Gly

250 255 260gtt gac ttg gtc acc cat ggc gtc act gag ctt gct gcg tgg aag ggt 931Val Asp Leu Val Thr His Gly Val Thr Glu Leu Ala Ala Trp Lys Gly

265 270 275gag gag ctg ctg gtt gcg ggc atc gtt gat ggt cgt aac att tgg cgc 979Glu Glu Leu Leu Val Ala Gly Ile Val Asp Gly Arg Asn Ile Trp Arg

280 285 290acc gac ctg tgt gct gct ctt gct tcc ctg aag cgc ctg gca gct cgc 1027Thr Asp Leu Cys Ala Ala Leu Ala Ser Leu Lys Arg Leu Ala Ala Arg

295 300 305ggc cca atc gca gtg tct acc tct tgt tca ctg ctg cac gtt cct tac 1075Gly Pro Ile Ala Val Ser Thr Ser Cys Ser Leu Leu His Val Pro Tyr310 315 320 325acc ctc gag gct gag aac att gag cct gag gtc cgc gac tgg ctt gcc 1123Thr Leu Glu Ala Glu Asn Ile Glu Pro Glu Val Arg Asp Trp Leu Ala

330 335 340ttc ggc tcg gag aag atc acc gag gtc aag ctg ctt gcc gac gcc cta 1171Phe Gly Ser Glu Lys Ile Thr Glu Val Lys Leu Leu Ala Asp Ala Leu

345 350 355gcc ggc aac atc gac gcg gct gcg ttc gat gcg gcg tcc gca gca att 1219Ala Gly Asn Ile Asp Ala Ala Ala Phe Asp Ala Ala Ser Ala Ala Ile

360365 370gct tct cga cgc acc tcc cca cgc acc gca cca atc acg cag gaa ctc 1267Ala Ser Arg Arg Thr Ser Pro Arg Thr Ala Pro Ile Thr Gln Glu Leu

375 380 385cct ggc cgt agc cgt gga tcc ttc gac act cgt gtt acg ctg cag gag 1315Pro Gly Arg Ser Arg Gly Ser Phe Asp Thr Arg Val Thr Leu Gln Glu390 395 400 405aag tca ctg gag ctt cca gct ctg cca acc acc acc att ggt tct ttc 1363Lys Ser Leu Glu Leu Pro Ala Leu Pro Thr Thr Thr Ile Gly Ser Phe

410 415 420cca cag acc cca tcc att cgt tct gct cgc gct cgt ctg cgc aag gaa 1411Pro Gln Thr Pro Ser Ile Arg Ser Ala Arg Ala Arg Leu Arg Lys Glu

425 430 435tcc atc act ttg gag cag tac gaa gag gca atg cgc gaa gaa atc gat 1459Ser Ile Thr Leu Glu Gln Tyr Glu Glu Ala Met Arg Glu Glu Ile Asp

440 445 450ctg gtc atc gcc aag cag gaa gaa ctt ggt ctt gat gtg ttg gtt cac 1507Leu Val Ile Ala Lys Gln Glu Glu Leu Gly Leu Asp Val Leu Val His

455 460 465ggt gag cca gag cgc aac gac atg gtt cag tac ttc tct gaa ctt ctc 1555Gly Glu Pro Glu Arg Asn Asp Met Val Gln Tyr Phe Ser Glu Leu Leu470 475 480 485gac ggt ttc ctc tca acc gcc aac ggc tgg gtc caa agc tac ggc tcc 1603Asp Gly Phe Leu Ser Thr Ala Asn Gly Trp Val Gln Ser Tyr Gly Ser

490 495 500cgc tgt gtt cgt cct cca gtg ttg ttc gga aac gtt tcc cgc cca gcg 1651Arg Cys Val Arg Pro Pro Val Leu Phe Gly Asn Val Ser Arg Pro Ala

505 510 515cca atg act gtc aag tgg ttc cag tac gca cag agc ctg acc cag aag 1699Pro Met Thr Val Lys Trp Phe Gln Tyr Ala Gln Ser Leu Thr Gln Lys

520 525 530cat gtc aag gga atg ctc acc ggt cca gtc acc atc ctt gca tgg tcc 1747His Val Lys Gly Met Leu Thr Gly Pro Val Thr Ile Leu Ala Trp Ser

535 540 545ttc gtt cgc gat gat cag ccg ctg gct acc act gct gac cag gtt gca 1795Phe Val Arg Asp Asp Gln Pro Leu Ala Thr Thr Ala Asp Gln Val Ala550 555 560 565ctg gca ctg cgc gat gaa att aac gat ctc atc gag gct ggc gcg aag 1843Leu Ala Leu Arg Asp Glu Ile Asn Asp Leu Ile Glu Ala Gly Ala Lys

570 575 580atc atc cag gtg gat gag cct gcg att cgt gaa ctg ttg ccc gct acg 1891Ile Ile Gln Val Asp Glu Pro Ala Ile Arg Glu Leu Leu Pro Ala Thr

585 590 595aga cgt cga taagcctgcc tacctgcagt ggt 1923Arg Arg Arg

600<210>716<211>600<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>716Met Thr Ser Asn Phe Ser Ser Thr Val Ala Gly Leu Pro Arg Ile Gly 151015 Ala Lys Arg Glu Leu Lys Phe Ala Leu Glu Gly Tyr Trp Asn Gly Ser

20 25 30Ile Glu Gly Arg Glu Leu Ala Gln Thr Ala Arg Gln Leu Val Asn Thr

35 40 45Ala Ser Asp Ser Leu Ser Gly Leu Asp Ser Val Pro Phe Ala Gly Arg

50 55 60Ser Tyr Tyr Asp Ala Met Leu Asp Thr Ala Ala Ile Leu Gly Val Leu 65 70 75 80Pro Glu Arg Phe Asp Asp Ile Ala Asp His Glu Asn Asp Gly Leu Pro

85 90 95Leu Trp Ile Asp Arg Tyr Phe Gly Ala Ala Arg Gly Thr Glu Thr Leu

100 105 110Pro Ala Gln Ala Met Thr Lys Trp Phe Asp Thr Asn Tyr His Tyr Leu

115 120 125Val Pro Glu Leu Ser Ala Asp Thr Arg Phe Val Leu Asp Ala Ser Ala

130 135 140Leu Ile Glu Asp Leu Arg Cys Gln Gln Val Arg Gly Val Asn Ala Arg145 150 155 160Pro Val Leu Val Gly Pro Leu Thr Phe Leu Ser Leu Ala Arg Thr Thr

165 170 175Asp Gly Ser Asn Pro Leu Asp His Leu Pro Ala Leu Phe Glu Val Tyr

180 185 190Glu Arg Leu Ile Lys Ser Phe Asp Thr Glu Trp Val Gln Ile Asp Glu

195 200 205Pro Ala Leu Val Thr Asp Val Ala Pro Glu Val Leu Glu Gln Val Arg

210 215 220Ala Gly Tyr Thr Thr Leu Ala Lys Arg Asp Gly Val Phe Val Asn Thr225 230 235 240Tyr Phe Gly Ser Gly Asp Gln Ala Leu Asn Thr Leu Ala Gly Ile Gly

245 250 255Leu Gly Ala Ile Gly Val Asp Leu Val Thr His Gly Val Thr Glu Leu

260 265 270Ala Ala Trp Lys Gly Glu Glu Leu Leu Val Ala Gly Ile Val Asp Gly

275 280 285Arg Asn Ile Trp Arg Thr Asp Leu Cys Ala Ala Leu Ala Ser Leu Lys

290 295 300Arg Leu Ala Ala Arg Gly Pro Ile Ala Val Ser Thr Ser Cys Ser Leu305 310 315320Leu His Val Pro Tyr Thr Leu Glu Ala Glu Asn Ile Glu Pro Glu Val

325 330 335Arg Asp Trp Leu Ala Phe Gly Ser Glu Lys Ile Thr Glu Val Lys Leu

340 345 350Leu Ala Asp Ala Leu Ala Gly Asn Ile Asp Ala Ala Ala Phe Asp Ala

355 360 365Ala Ser Ala Ala Ile Ala Ser Arg Arg Thr Ser Pro Arg Thr Ala Pro

370 375 380Ile Thr Gln Glu Leu Pro Gly Arg Ser Arg Gly Ser Phe Asp Thr Arg385 390 395 400Val Thr Leu Gln Glu Lys Ser Leu Glu Leu Pro Ala Leu Pro Thr Thr

405 410 415Thr Ile Gly Ser Phe Pro Gln Thr Pro Ser Ile Arg Ser Ala Arg Ala

420 425 430Arg Leu Arg Lys Glu Ser Ile Thr Leu Glu Gln Tyr Glu Glu Ala Met

435 440 445Arg Glu Glu Ile Asp Leu Val Ile Ala Lys Gln Glu Glu Leu Gly Leu

450 455 460Asp Val Leu Val His Gly Glu Pro Glu Arg Asn Asp Met Val Gln Tyr465 470 475 480Phe Ser Glu Leu Leu Asp Gly Phe Leu Ser Thr Ala Asn Gly Trp Val

485 490 495Gln Ser Tyr Gly Ser Arg Cys Val Arg Pro Pro Val Leu Phe Gly Asn

500 505 510Val Ser Arg Pro Ala Pro Met Thr Val Lys Trp Phe Gln Tyr Ala Gln

515 520 525Ser Leu Thr Gln Lys His Val Lys Gly Met Leu Thr Gly Pro Val Thr

530 535 540Ile Leu Ala Trp Ser Phe Val Arg Asp Asp Gln Pro Leu Ala Thr Thr545 550 555 560Ala Asp Gln Val Ala Leu Ala Leu Arg Asp Glu Ile Asn Asp Leu Ile

565 570 575Glu Ala Gly Ala Lys Ile Ile Gln Val Asp Glu Pro Ala Ile Arg Glu

580 585 590Leu Leu Pro Ala Thr Arg Arg Arg

595600<210>717<211>603<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (580)<223>FRXA02086<400>717gatgatcagc cgctggctac cactgctgac caggttgcac tggcactgcg cgatgaaatt 60aacgatctca tcgaggctgg cgcgaagatc atccaggtgg atg agc ctg cga ttc 115

Met Ser Leu Arg Phe

1 5gtg aac tgt tgc ccg cta cga gac gtc gat aag cct gcc tac ctg cag 163Val Asn Cys Cys Pro Leu Arg Asp Val Asp Lys Pro Ala Tyr Leu Gln

10 15 20tgg tcc gtg gac tcc ttc cgc ctg gcg act gcc ggc gca ccc gac gac 211Trp Ser Val Asp Ser Phe Arg Leu Ala Thr Ala Gly Ala Pro Asp Asp

25 30 35gtc caa atc cac acc cac atg tgc tac tcc gag ttc aac gaa gtg atc 259Val Gln Ile His Thr His Met Cys Tyr Ser Glu Phe Asn Glu Val Ile

40 45 50tcc tcg gtc atc gcg ttg gat gcc gat gtc acc acc atc gaa gca gca 307Ser Ser Val Ile Ala Leu Asp Ala Asp Val Thr Thr Ile Glu Ala Ala

55 60 65cgt tcc gac atg cag gtc ctc gct gctctg aaa tct tcc ggc ttc gag 355Arg Ser Asp Met Gln Val Leu Ala Ala Leu Lys Ser Ser Gly Phe Glu 70 75 80 85ctc ggc gtc gga cct ggt gtg tgg gat atc cac tcc ccg cgc gtt cct 403Leu Gly Val Gly Pro Gly Val Trp Asp Ile His Ser Pro Arg Val Pro

90 95 100tcc gcg cag aaa gtg gac ggt ctc ctc gag gct gca ctg cag tcc gtg 451Ser Ala Gln Lys Val Asp Gly Leu Leu Glu Ala Ala Leu Gln Ser Val

105 110 115gat cct cgc cag ctg tgg gtc aac cca gac tgt ggt ctg aag acc cgt 499Asp Pro Arg Gln Leu Trp Val Asn Pro Asp Cys Gly Leu Lys Thr Arg

120 125 130gga tgg cca gaa gtg gaa gct tcc cta aag gtt ctc gtt gag tcc gct 547Gly Trp Pro Glu Val Glu Ala Ser Leu Lys Val Leu Val Glu Ser Ala

135140145 aag cag gct cgt gag aaa atc gga gca act atc taaattgggt taccgctagg 600Lys Gln Ala Arg Glu Lys Ile Gly Ala Thr Ile 150155160 aac 603<210>718<211>160<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>718Met Ser Leu Arg Phe Val Asn Cys Cys Pro Leu Arg Asp Val Asp Lys 151015 Pro Ala Tyr Leu Gln Trp Ser Val Asp Ser Phe Arg Leu Ala Thr Ala

20 25 30Gly Ala Pro Asp Asp Val Gln Ile His Thr His Met Cys Tyr Ser Glu

35 40 45Phe Asn Glu Val Ile Ser Ser Val Ile Ala Leu Asp Ala Asp Val Thr

50 55 60Thr Ile Glu Ala Ala Arg Ser Asp Met Gln Val Leu Ala Ala Leu Lys 65 70 75 80Ser Ser Gly Phe Glu Leu Gly Val Gly Pro Gly Val Trp Asp Ile His

85 90 95Ser Pro Arg Val Pro Ser Ala Gln Lys Val Asp Gly Leu Leu Glu Ala

100 105 110Ala Leu Gln Ser Val Asp Pro Arg Gln Leu Trp Val Asn Pro Asp Cys

115 120 125Gly Leu Lys Thr Arg Gly Trp Pro Glu Val Glu Ala Ser Leu Lys Val

130135140 Leu Val Glu Ser Ala Lys Gln Ala Arg Glu Lys Ile Gly Ala Thr Ile 145150155160<210>719<211>1326<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1303)<223>RXN02648<400>719atgaataaaa ttccgggtgc agtgaccgta ggtgaggtaa acgcggttag agtcgaatga 60gagtttgata ctttctttcg acttttagat tggattttca atg agc cag aac cgc 115

Met Ser Gln Asn Arg

1 5atc agg acc act cac gtt ggt tcc ttg ccc cgt acc cca gag cta ctt 163Ile Arg Thr Thr His Val Gly Ser Leu Pro Arg Thr Pro Glu Leu Leu

10 15 20gat gca aac atc aag cgt tct aac ggt gag att ggg gag gag gaa ttc 211Asp Ala Asn Ile Lys Arg Ser Asn Gly Glu Ile Gly Glu Glu Glu Phe

25 30 35ttc cag att ctg cag tct tct gta gat gac gtg atc aag cgc cag gtt 259Phe Gln Ile Leu Gln Ser Ser Val Asp Asp Val Ile Lys Arg Gln Val

40 45 50gac ctg ggt atc gac atc ctt aac gag ggc gaa tac ggc cac gtc acc 307Asp Leu Gly Ile Asp Ile Leu Asn Glu Gly Glu Tyr Gly His Val Thr

55 60 65tcc ggt gca gtt gac ttc ggt gca tgg tgg aac tac tcc ttc acc cgc 355Ser Gly Ala ValAsp Phe Gly Ala Trp Trp Asn Tyr Ser Phe Thr Arg 70 75 80 85ctg ggc gga ctg acc atg acc gat acc gac cgt tgg gca agc cag gaa 403Leu Gly Gly Leu Thr Met Thr Asp Thr Asp Arg Trp Ala Ser Gln Glu

90 95 100gca gtg cgt tcc acc cct ggc aac atc gag ctg acc agc ttc tct gat 451Ala Val Arg Ser Thr Pro Gly Asn Ile Glu Leu Thr Ser Phe Ser Asp

105 110 115cgt cgc gac cgc gca ttg ttc agc gaa gca tac gag gat cca gta tct 499Arg Arg Asp Arg Ala Leu Phe Ser Glu Ala Tyr Glu Asp Pro Val Ser

120 125 130ggc atc ttc acc ggt cgc gct tct gtg ggc aac cca gag ttc acc gga 547Gly Ile Phe Thr Gly Arg Ala Ser Val Gly Asn Pro Glu Phe Thr Gly

135 140 145cct att acc tac att ggc cag gaa gaa act cag acg gat gtt gat ctg 595Pro Ile Thr Tyr Ile Gly Gln Glu Glu Thr Gln Thr Asp Val Asp Leu150 155 160 165ctg aag aag ggc atg aac gca gcg gga gct acc gac ggc ttc gtt gca 643Leu Lys Lys Gly Met Asn Ala Ala Gly Ala Thr Asp Gly Phe Val Ala

170 175 180gca cta tcc cca gga tct gca gct cga ttg acc aac aag ttc tac gac 691Ala Leu Ser Pro Gly Ser Ala Ala Arg Leu Thr Asn Lys Phe Tyr Asp

185 190 195act gat gaa gaa gtc gtc gca gca tgt gct gat gcg ctt tcc cag gaa 739Thr Asp Glu Glu Val Val Ala Ala Cys Ala Asp Ala Leu Ser Gln Glu

200 205 210tac aag atc atc acc gat gca ggt ctg acc gtt cag ctc gac gca ccg 787Tyr Lys Ile Ile Thr Asp Ala Gly Leu Thr Val Gln Leu Asp Ala Pro

215220 225gac ttg gca gaa gca tgg gat cag atc aac cca gag cca agc gtg aag 835Asp Leu Ala Glu Ala Trp Asp Gln Ile Asn Pro Glu Pro Ser Val Lys230 235 240 245gat tac ttg gac tgg atc ggt aca cgc atc gat gcc atc aac agt gca 883Asp Tyr Leu Asp Trp Ile Gly Thr Arg Ile Asp Ala Ile Asn Ser Ala

250 255 260gtg aag ggc ctt cca aag gaa cag acc cgc ctg cac atc tgc tgg ggc 931Val Lys Gly Leu Pro Lys Glu Gln Thr Arg Leu His Ile Cys Trp Gly

265 270 275tct tgg cac gga cca cac gtc act gac atc cca ttc ggt gac atc att 979Ser Trp His Gly Pro His Val Thr Asp Ile Pro Phe Gly Asp Ile Ile

280 285 290ggt gag atc ctg cgc gca gag gtc ggt ggc ttc tcc ttc gaa ggc gca 1027Gly Glu Ile Leu Arg Ala Glu Val Gly Gly Phe Ser Phe Glu Gly Ala

295 300 305tct cct cgt cac gca cac gag tgg cgt gta tgg gaa gaa aac aag ctt 1075Ser Pro Arg His Ala His Glu Trp Arg Val Trp Glu Glu Asn Lys Leu310 315 320 325cct gaa ggc tct gtt atc tac cct ggt gtt gtg tct cac tcc atc aac 1123Pro Glu Gly Ser Val Ile Tyr Pro Gly Val Val Ser His Ser Ile Asn

330 335 340gct gtg gag cac cca cgc ctg gtt gct gat cgt atc gtt cag ttc gcc 1171Ala Val Glu His Pro Arg Leu Val Ala Asp Arg Ile Val Gln Phe Ala

345 350 355aag ctt gtt ggc cct gag aac gtc att gcg tcc act gac tgt ggt ctg 1219Lys Leu Val Gly Pro Glu Asn Val Ile Ala Ser Thr Asp Cys Gly Leu

360 365 370ggc gga cgt ctg cat tcc cag atc gca tgg gca aag ctg gag tcc cta 1267Gly Gly Arg Leu His Ser Gln Ile Ala Trp Ala Lys Leu Glu Ser Leu

375380385 gta gag ggc gct cgc att gca tca aag gaa ctg ttc taagctagac 1313Val Glu Gly Ala Arg Ile Ala Ser Lys Glu Leu Phe 390395400 aacgagggttt gct 1326<210>720<211>401<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>720Met Ser Gln Asn Arg Ile Arg Thr Thr His Val Gly Ser Leu Pro Arg 151015 Thr Pro Glu Leu Leu Asp Ala Asn Ile Lys Arg Ser Asn Gly Glu Ile

20 25 30Gly Glu Glu Glu Phe Phe Gln Ile Leu Gln Ser Ser Val Asp Asp Val

35 40 45Ile Lys Arg Gln Val Asp Leu Gly Ile Asp Ile Leu Asn Glu Gly Glu

50 55 60Tyr Gly His Val Thr Ser Gly Ala Val Asp Phe Gly Ala Trp Trp Asn 65 70 75 80Tyr Ser Phe Thr Arg Leu Gly Gly Leu Thr Met Thr Asp Thr Asp Arg

85 90 95Trp Ala Ser Gln Glu Ala Val Arg Ser Thr Pro Gly Asn Ile Glu Leu

100 105 110Thr Ser Phe Ser Asp Arg Arg Asp Arg Ala Leu Phe Ser Glu Ala Tyr

115 120 125Glu Asp Pro Val Ser Gly Ile Phe Thr Gly Arg Ala Ser Val Gly Asn

130 135 140Pro Glu Phe Thr Gly Pro Ile Thr Tyr Ile Gly Gln Glu Glu Thr Gln145 150 155 160Thr Asp Val Asp Leu Leu Lys Lys Gly Met Asn Ala Ala Gly Ala Thr

165 170 175Asp Gly Phe Val Ala Ala Leu Ser Pro Gly Ser Ala Ala Arg Leu Thr

180 185 190Asn Lys Phe Tyr Asp Thr Asp Glu Glu Val Val Ala Ala Cys Ala Asp

195 200 205Ala Leu Ser Gln Glu Tyr Lys Ile Ile Thr Asp Ala Gly Leu Thr Val

210 215 220Gln Leu Asp Ala Pro Asp Leu Ala Glu Ala Trp Asp Gln Ile Asn Pro225 230 235 240Glu Pro Ser Val Lys Asp Tyr Leu Asp Trp Ile Gly Thr Arg Ile Asp

245 250 255Ala Ile Asn Ser Ala Val Lys Gly Leu Pro Lys Glu Gln Thr Arg Leu

260 265 270His Ile Cys Trp Gly Ser Trp His Gly Pro His Val Thr Asp Ile Pro

275 280 285Phe Gly Asp Ile Ile Gly Glu Ile Leu Arg Ala Glu Val Gly Gly Phe

290 295 300Ser Phe Glu Gly Ala Ser Pro Arg His Ala His Glu Trp Arg Val Trp305 310 315 320Glu Glu Asn Lys Leu Pro Glu Gly Ser Val Ile Tyr Pro Gly Val Val

325 330 335Ser His Ser Ile Asn Ala Val Glu His Pro Arg Leu Val Ala Asp Arg

340 345 350Ile Val Gln Phe Ala Lys Leu Val Gly Pro Glu Asn Val Ile Ala Ser

355 360 365Thr Asp Cys Gly Leu Gly Gly Arg Leu His Ser Gln Ile Ala Trp Ala

370375380 Lys Leu Glu Ser Leu Val Glu Gly Ala Arg Ile Ala Ser Lys Glu Leu 385390395400 Phe<210>721<211>548<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (525)<223>FRXA02648<400>721gac gca ccg gac ttg gca gaa gca tgg gat cag atc aac cca gag cca 48Asp Ala Pro Asp Leu Ala Glu Ala Trp Asp Gln Ile Asn Pro Glu Pro 151015 agc gtg aag gat tac ttg gac tgg atc ggt aca cgc atc gat gcc atc 96Ser Val Lys Asp Tyr Leu Asp Trp Ile Gly Thr Arg Ile Asp Ala Ile

20 25 30aac agt gca gtg aag ggc ctt cca aag gaa cag acc cgc ctg cac atc 144Asn Ser Ala Val Lys Gly Leu Pro Lys Glu Gln Thr Arg Leu His Ile

35 40 45tgc tgg ggc tct tgg cac gga cca cac gtc act gac atc cca ttc ggt 192Cys Trp Gly Ser Trp His Gly Pro His Val Thr Asp Ile Pro Phe Gly

50 55 60gac atc att ggt gag atc ctg cgc gca gag gtc ggt ggc ttc tcc ttc 240Asp Ile Ile Gly Glu Ile Leu Arg Ala Glu Val Gly Gly Phe Ser Phe 65 70 75 80gaa ggc gca tct cct cgt cac gca cac gag tgg cgt gta tgg gaa gaa 288Glu Gly Ala Ser Pro Arg His Ala His Glu Trp Arg Val Trp Glu Glu

85 90 95aac aag ctt cct gaa ggc tct gtt atc tac cct ggt gtt gtg tct cac 336Asn Lys Leu Pro Glu Gly Ser Val Ile Tyr Pro Gly Val Val Ser His

100 105 110tcc atc aac gct gtg gag cac cca cgc ctg gtt gct gat cgt atc gtt 384Ser Ile Asn Ala Val Glu His Pro Arg Leu Val Ala Asp Arg Ile Val

115 120 125cag ttc gcc aag ctt gtt ggc cct gag aac gtc att gcg tcc act gac 432Gln Phe Ala Lys Leu Val Gly Pro Glu Asn Val Ile Ala Ser Thr Asp

130 135 140tgt ggt ctg ggc gga cgt ctg cat tcc cag atc gca tgg gca aag ctg 480Cys Gly Leu Gly Gly Arg Leu His Ser Gln Ile Ala Trp Ala Lys Leu145150 155 160gag tcc cta gta gag ggc gct cgc att gca tca aag gaa ctg ttc 525Glu Ser Leu Val Glu Gly Ala Arg Ile Ala Ser Lys Glu Leu Phe

165170175 taagctagac aacgagggtt gct 548<210>722<211>175<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>722Asp Ala Pro Asp Leu Ala Glu Ala Trp Asp Gln Ile Asn Pro Glu Pro 151015 Ser Val Lys Asp Tyr Leu Asp Trp Ile Gly Thr Arg Ile Asp Ala Ile

20 25 30Asn Ser Ala Val Lys Gly Leu Pro Lys Glu Gln Thr Arg Leu His Ile

35 40 45Cys Trp Gly Ser Trp His Gly Pro His Val Thr Asp Ile Pro Phe Gly

50 55 60Asp Ile Ile Gly Glu Ile Leu Arg Ala Glu Val Gly Gly Phe Ser Phe 65 70 75 80Glu Gly Ala Ser Pro Arg His Ala His Glu Trp Arg Val Trp Glu Glu

85 90 95Asn Lys Leu Pro Glu Gly Ser Val Ile Tyr Pro Gly Val Val Ser His

100 105 110Ser Ile Asn Ala Val Glu His Pro Arg Leu Val Ala Asp Arg Ile Val

115 120 125Gln Phe Ala Lys Leu Val Gly Pro Glu Asn Val Ile Ala Ser Thr Asp

130 135 140Cys Gly Leu Gly Gly Arg Leu His Ser Gln Ile Ala Trp Ala Lys Leu145 150 155 160Glu Ser Leu Val Glu Gly Ala Arg Ile Ala Ser Lys Glu Leu Phe

165170175<210>723<211>784<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101)}, (784)<223>FRXA02658<400>723atgaataaaa ttccgggtgc agtgaccgta ggtgaggtaa acgcggttag agtcgaatga 60gagtttgata ctttctttcg acttttagat tggattttca atg agc cag aac cgc 115

Met Ser Gln Asn Arg

1 5atc agg acc act cac gtt ggt tcc ttg ccc cgt acc cca gag cta ctt 163Ile Arg Thr Thr His Val Gly Ser Leu Pro Arg Thr Pro Glu Leu Leu

10 15 20gat gca aac atc aag cgt tct aac ggt gag att ggg gag gag gaa ttc 211Asp Ala Asn Ile Lys Arg Ser Asn Gly Glu Ile Gly Glu Glu Glu Phe

25 30 35ttc cag att ctg cag tct tct gta gat gac gtg atc aag cgc cag gtt 259Phe Gln Ile Leu Gln Ser Ser Val Asp Asp Val Ile Lys Arg Gln Val

40 45 50gac ctg ggt atc gac atc ctt aac gag ggc gaa tac ggc cac gtc acc 307Asp Leu Gly Ile Asp Ile Leu Asn Glu Gly Glu Tyr Gly His Val Thr

55 60 65tcc ggt gca gtt gac ttc ggt gca tgg tgg aac tac tcc ttc acc cgc 355Ser Gly Ala Val Asp Phe Gly Ala Trp Trp Asn Tyr Ser Phe Thr Arg 70 75 80 85ctg ggc gga ctg acc atg acc gat acc gac cgt tgg gca agc cag gaa 403Leu Gly Gly Leu Thr Met Thr Asp Thr Asp Arg Trp Ala Ser Gln Glu

90 95 100gca gtg cgt tcc acc cct ggc aac atc gag ctg acc agc ttc tct gat 451Ala Val Arg Ser Thr Pro Gly Asn Ile Glu Leu Thr Ser Phe Ser Asp

105 110 115cgt cgc gac cgc gca ttg ttc agc gaa gca tac gag gat cca gta tct 499Arg Arg Asp Arg Ala Leu Phe Ser Glu Ala Tyr Glu Asp Pro Val Ser

120 125 130ggc atc ttc acc ggt cgc gct tct gtg ggc aac cca gag ttc acc gga 547Gly Ile Phe Thr Gly Arg Ala Ser Val Gly Asn Pro Glu Phe Thr Gly

135 140 145cct att acc tac att ggc cag gaa gaa act cag acg gat gtt gat ctg 595Pro Ile Thr Tyr Ile Gly Gln Glu Glu Thr Gln Thr Asp Val Asp Leu150 155 160 165ctg aag aag ggc atg aac gca gcg gga gct acc gac ggc ttc gtt gca 643Leu Lys Lys Gly Met Asn Ala Ala Gly Ala Thr Asp Gly Phe Val Ala

170 175 180gca cta tcc cca gga tct gca gct cga ttg acc aac aag ttc tac gac 691Ala Leu Ser Pro Gly Ser Ala Ala Arg Leu Thr Asn Lys Phe Tyr Asp

185 190 195act gat gaa gaa gtc gtc gca gca tgt gct gat gcg ctt tcc cag gaa 739Thr Asp Glu Glu Val Val Ala Ala Cys Ala Asp Ala Leu Ser Gln Glu

200 205 210tac aag atc atc acc gat gca ggt ctg acc gtt cag ctc gac gca 784Tyr Lys Ile Ile Thr Asp Ala Gly Leu Thr Val Gln Leu Asp Ala

215220225<210>724<211>228<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>724Met Ser Gln Asn Arg Ile Arg Thr Thr His Val Gly Ser Leu Pro Arg 151015 Thr Pro Glu Leu Leu Asp Ala Asn Ile Lys Arg Ser Asn Gly Glu Ile

20 25 30Gly Glu Glu Glu Phe Phe Gln Ile Leu Gln Ser Ser Val Asp Asp Val

35 40 45Ile Lys Arg Gln Val Asp Leu Gly Ile Asp Ile Leu Asn Glu Gly Glu

50 55 60Tyr Gly His Val Thr Ser Gly Ala Val Asp Phe Gly Ala Trp Trp Asn 65 70 75 80Tyr Ser Phe Thr Arg Leu Gly Gly Leu Thr Met Thr Asp Thr Asp Arg

85 90 95Trp Ala Ser Gln Glu Ala Val Arg Ser Thr Pro Gly Asn Ile Glu Leu

100 105 110Thr Ser Phe Ser Asp Arg Arg Asp Arg Ala Leu Phe Ser Glu Ala Tyr

115 120 125Glu Asp Pro Val Ser Gly Ile Phe Thr Gly Arg Ala Ser Val Gly Asn

130 135 140Pro Glu Phe Thr Gly Pro Ile Thr Tyr Ile Gly Gln Glu Glu Thr Gln145 150 155 160Thr Asp Val Asp Leu Leu Lys Lys Gly Met Asn Ala Ala Gly Ala Thr

165 170 175Asp Gly Phe Val Ala Ala Leu Ser Pro Gly Ser Ala Ala Arg Leu Thr

180 185 190Asn Lys Phe Tyr Asp Thr Asp Glu Glu Val Val Ala Ala Cys Ala Asp

195 200 205Ala Leu Ser Gln Glu Tyr Lys Ile Ile Thr Asp Ala Gly Leu Thr Val

210215220 Gln Leu Asp Ala225<225>725<211>551<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) } (528)<223>RXS02197<400>725gcc gaa cgc atg cgc ttt agc ttc cca cgc cag cag cgc ggc agg ttc 48Ala Glu Arg Met Arg Phe Ser Phe Pro Arg Gln Gln Arg Gly Arg Phe 151015 ttg tgc atc gcg gat ttc att cgc cca cgc gag caa gct gtc aag gac 96Leu Cys Ile Ala Asp Phe Ile Arg Pro Arg Glu Gln Ala Val Lys Asp

20 25 30ggc caa gtg gac gtc atg cca ttc cag ctg gtc acc atg ggt aat cct 144Gly Gln Val Asp Val Met Pro Phe Gln Leu Val Thr Met Gly Asn Pro

35 40 45att gct gat ttc gcc aac gag ttg ttc gca gcc aat gaa tac cgc gag 192Ile Ala Asp Phe Ala Asn Glu Leu Phe Ala Ala Asn Glu Tyr Arg Glu

50 55 60tac ttg gaa gtt cac ggc atc ggc gtg cag ctc acc gaa gca ttg gcc 240Tyr Leu Glu Val His Gly Ile Gly Val Gln Leu Thr Glu Ala Leu Ala 65 70 75 80gag tac tgg cac tcc cga gtg cgc agc gaa ctc aag ctg aac gac ggt 288Glu Tyr Trp His Ser Arg Val Arg Ser Glu Leu Lys Leu Asn Asp Gly

85 90 95gga tct gtc gct gat ttt gat cca gaa gac aag acc aag ttc ttc gac 336Gly Ser Val Ala Asp Phe Asp Pro Glu Asp Lys Thr Lys Phe Phe Asp

100 105 110ctg gat tac cgc ggc gcc cgc ttc tcc ttt ggt tac ggt tct tgc cct 384Leu Asp Tyr Arg Gly Ala Arg Phe Ser Phe Gly Tyr Gly Ser Cys Pro

115 120 125gat ctg gaa gac cgc gca aag ctg gtg gaa ttg ctc gag cca ggc cgt 432Asp Leu Glu Asp Arg Ala Lys Leu Val Glu Leu Leu Glu Pro Gly Arg

130 135 140atc ggc gtg gag ttg tcc gag gaa ctc cag ctg cac cca gag cag tcc 480Ile Gly Val Glu Leu Ser Glu Glu Leu Gln Leu His Pro Glu Gln Ser145 150 155 160aca gac gcg ttt gtg ctc tac cac cca gag gca aag tac ttt aac gtc 528Thr Asp Ala Phe Val Leu Tyr His Pro Glu Ala Lys Tyr Phe Asn Val

165170175 taacaccttt gagagggaaa act 551<210>726<211>176<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>726Ala Glu Arg Met Arg Phe Ser Phe Pro Arg Gln Gln Arg Gly Arg Phe 151015 LeuCys Ile Ala Asp Phe Ile Arg Pro Arg Glu Gln Ala Val Lys Asp

20 25 30Gly Gln Val Asp Val Met Pro Phe Gln Leu Val Thr Met Gly Asn Pro

35 40 45Ile Ala Asp Phe Ala Asn Glu Leu Phe Ala Ala Asn Glu Tyr Arg Glu

50 55 60Tyr Leu Glu Val His Gly Ile Gly Val Gln Leu Thr Glu Ala Leu Ala 65 70 75 80Glu Tyr Trp His Ser Arg Val Arg Ser Glu Leu Lys Leu Asn Asp Gly

85 90 95Gly Ser Val Ala Asp Phe Asp Pro Glu Asp Lys Thr Lys Phe Phe Asp

100 105 110Leu Asp Tyr Arg Gly Ala Arg Phe Ser Phe Gly Tyr Gly Ser Cys Pro

115 120 125Asp Leu Glu Asp Arg Ala Lys Leu Val Glu Leu Leu Glu Pro Gly Arg

130 135 140Ile Gly Val Glu Leu Ser Glu Glu Leu Gln Leu His Pro Glu Gln Ser145 150 155 160Thr Asp Ala Phe Val Leu Tyr His Pro Glu Ala Lys Tyr Phe Asn Val

165170175<210>727<211>546<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (523)<223>RXC00988<400>727tagcagaaga caccgatgta cagtccggat caggtgttgt gatcaccggt tcaatcgtga 60ccgccggcga tgcgcgcacg ctgtttggaa aggaacctgc atg agc aag cgt gaa 115

Met Ser Lys Arg Glu

1 5gaa tca att gag tac gga cca tta ggc aaa ggc cac gat cca tta aag 163Glu Ser Ile Glu Tyr Gly Pro Leu Gly Lys Gly His Asp Pro Leu Lys

10 15 20gat ccc atg aag ggt atc cga ggt gtc atg gcc ggc acc tta gtg atg 211Asp Pro Met Lys Gly Ile Arg Gly Val Met Ala Gly Thr Leu Val Met

25 30 35gaa gca atc acc tta ggt ctt gtt ctc acc gtg att ctg cgc gtg gac 259Glu Ala Ile Thr Leu Gly Leu Val Leu Thr Val Ile Leu Arg Val Asp

40 45 50gac ggc atc tac tgg acc acc ttc aac tgg gtc tat gta tca gca gtc 307Asp Gly Ile Tyr Trp Thr Thr Phe Asn Trp Val Tyr Val Ser Ala Val

55 60 65gcg atc gca cac ttt gtt gct gca ttt ctg caa agg ttt agt tgg tcc 355Ala Ile Ala His Phe Val Ala Ala Phe Leu Gln Arg Phe Ser Trp Ser 70 75 80 85atc ccg atg aac atc gtg ctg cag gtt ctt gca ctt gcc ggt ttc ttt 403Ile Pro Met Asn Ile Val Leu Gln Val Leu Ala Leu Ala Gly Phe Phe

90 95 100gtt cac ccc gcg atg ggc ttc gcc gcc atc atc ttc atc atc gcg tgg 451Val His Pro Ala Met Gly Phe Ala Ala Ile Ile Phe Ile Ile Ala Trp

105 110 115gcg tac ctg ttc tac ctg cgc tct aat ctg att gat cgc atg aaa cgc 499Ala Tyr Leu Phe Tyr Leu Arg Ser Asn Leu Ile Asp Arg Met Lys Arg

120 125 130ggg ctg ctt acc acg cag cac agc taagctttaa ggccctccgg ggc 546Gly Leu Leu Thr Thr Gln His Ser

135140<210>728<211>141<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>728Met Ser Lys Arg Glu Glu Ser Ile Glu Tyr Gly Pro Leu Gly Lys Gly 151015 His AspPro Leu Lys Asp Pro Met Lys Gly Ile Arg Gly Val Met Ala

20 25 30Gly Thr Leu Val Met Glu Ala Ile Thr Leu Gly Leu Val Leu Thr Val

35 40 45Ile Leu Arg Val Asp Asp Gly Ile Tyr Trp Thr Thr Phe Asn Trp Val

50 55 60Tyr Val Ser Ala Val Ala Ile Ala His Phe Val Ala Ala Phe Leu Gln 65 70 75 80Arg Phe Ser Trp Ser Ile Pro Met Asn Ile Val Leu Gln Val Leu Ala

85 90 95Leu Ala Gly Phe Phe Val His Pro Ala Met Gly Phe Ala Ala Ile Ile

100 105 110Phe Ile Ile Ala Trp Ala Tyr Leu Phe Tyr Leu Arg Ser Asn Leu Ile

115 120 125Asp Arg Met Lys Arg Gly Leu Leu Thr Thr Gln His Ser

130135140<210>729<211>597<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<574)<223>RXC01518<400>729agcagaacct gatgccgtcc tgcacggcac gaccattgca gaacatgtgg ataatcttga 60tcccacagac attgaaggtg tcaccaagat ttaaggagtc gtg gct ttc atg cag 115

Val Ala Phe Met Gln

1 5aaa acg tca gcg ggt tgg ttg atc gca acg gga ggt ttc ctc gcc gct 163Lys Thr Ser Ala Gly Trp Leu Ile Ala Thr Gly Gly Phe Leu Ala Ala

10 15 20gtg tcc gcc att ttg acg tgg cgt ttt tat gga tcc atg acc tct att 211Val Ser Ala Ile Leu Thr Trp Arg Phe Tyr Gly Ser Met Thr Ser Ile

25 30 35tcc atc acg gta tcc atc act ttt tgg ttg ttg gcc gtg gtg tgt ggt 259Ser Ile Thr Val Ser Ile Thr Phe Trp Leu Leu Ala Val Val Cys Gly

40 45 50ttc gca ggt gtg aag gtc caa ggt cgc ctc gat gag ggg ctg atc ggc 307Phe Ala Gly Val Lys Val Gln Gly Arg Leu Asp Glu Gly Leu Ile Gly

55 60 65cag gac aaa tcc caa atg aac ccc gtg acc att gcc tat ctg gcc atg 355Gln Asp Lys Ser Gln Met Asn Pro Val Thr Ile Ala Tyr Leu Ala Met 70 75 80 85ctg ggt cga gcg tgt gcg tgg ggt ggc gca att ttc ggc ggc gtt tat 403Leu Gly Arg Ala Cys Ala Trp Gly Gly Ala Ile Phe Gly Gly Val Tyr

90 95 100gtg gga att ggc agt tat gta atc cca cgc gcc ggt gag ttg tcc gca 451Val Gly Ile Gly Ser Tyr Val Ile Pro Arg Ala Gly Glu Leu Ser Ala

105 110 115gca tcg aat gat ctt ccg gga gtt att gcc tgt gcg ctg ggc gga atc 499Ala Ser Asn Asp Leu Pro Gly Val Ile Ala Cys Ala Leu Gly Gly Ile

120 125 130gca ctc tca gct gcc gga ctt tat tta gag cga agc tgt gag gct ccg 547Ala Leu Ser Ala Ala Gly Leu Tyr Leu Glu Arg Ser Cys Glu Ala Pro

135140145 cct ccc caa tct ggc gaa gcg atc agc tagattggaa ttcatgaatc 594Pro Pro Gln Ser Gly Glu Ala Ile Ser 150155 aag 597<210>730<211>158<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>730Val Ala Phe Met Gln Lys Thr Ser Ala Gly Trp Leu Ile Ala Thr Gly 151015 Gly Phe Leu Ala Ala Val Ser Ala Ile Leu Thr Trp Arg Phe Tyr Gly

20 25 30Ser Met Thr Ser IleSer Ile Thr Val Ser Ile Thr Phe Trp Leu Leu

35 40 45Ala Val Val Cys Gly Phe Ala Gly Val Lys Val Gln Gly Arg Leu Asp

50 55 60Glu Gly Leu Ile Gly Gln Asp Lys Ser Gln Met Asn Pro Val Thr Ile 65 70 75 80Ala Tyr Leu Ala Met Leu Gly Arg Ala Cys Ala Trp Gly Gly Ala Ile

85 90 95Phe Gly Gly Val Tyr Val Gly Ile Gly Ser Tyr Val Ile Pro Arg Ala

100 105 110Gly Glu Leu Ser Ala Ala Ser Asn Asp Leu Pro Gly Val Ile Ala Cys

115 120 125Ala Leu Gly Gly Ile Ala Leu Ser Ala Ala Gly Leu Tyr Leu Glu Arg

130135140 Ser Cys Glu Ala Pro Pro Pro Gln Ser Gly Glu Ala Ile Ser 145150155<210>731<211>723<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).)

Met Leu Arg Ile Gly

1 5cta aca gga ggg atc ggc agc ggt aaa tct acc gtt gcc gat ctt ttg 163Leu Thr Gly Gly Ile Gly Ser Gly Lys Ser Thr Val Ala Asp Leu Leu

10 15 20tca tct gaa gga ttt ctc atc gtc gac gcg gac caa gtt gcc cgc gat 211Ser Ser Glu Gly Phe Leu Ile Val Asp Ala Asp Gln Val Ala Arg Asp

25 30 35atc gtc gaa ccc gga caa ccg gca tta gca gag cta gct gaa gct ttt 259Ile Val Glu Pro Gly Gln Pro Ala Leu Ala Glu Leu Ala Glu Ala Phe

4045 50ggc caa gac atc tta aaa ccc gac ggc act cta gac cgc gcg gga tta 307Gly Gln Asp Ile Leu Lys Pro Asp Gly Thr Leu Asp Arg Ala Gly Leu

55 60 65gca gcc aaa gca ttt gtc agc gaa gaa caa aca gcg ctg ctc aat gcc 355Ala Ala Lys Ala Phe Val Ser Glu Glu Gln Thr Ala Leu Leu Asn Ala 70 75 80 85att acc cac cct cgt atc gcc gaa gag tca gct cgt cga ttc aac gaa 403Ile Thr His Pro Arg Ile Ala Glu Glu Ser Ala Arg Arg Phe Asn Glu

90 95 100gcc gaa gat caa ggc gcc aaa gtt gcg gtt tat gac atg cct ttg ctt 451Ala Glu Asp Gln Gly Ala Lys Val Ala Val Tyr Asp Met Pro Leu Leu

105 110 115gta gaa aaa ggc ctt gac cgc aag atg gac ctt gtc gtc gta gtt gat 499Val Glu Lys Gly Leu Asp Arg Lys Met Asp Leu Val Val Val Val Asp

120 125 130gtt gac gta gag gaa cgc gtc cgc aga ctt gtg gaa aaa cgt ggc ctc 547Val Asp Val Glu Glu Arg Val Arg Arg Leu Val Glu Lys Arg Gly Leu

135 140 145aca gag gac gac gtg cgg cgt cga atc gct tct caa gtg ccc gac gac 595Thr Glu Asp Asp Val Arg Arg Arg Ile Ala Ser Gln Val Pro Asp Asp150 155 160 165gtc aga ctt aaa gcc gct gac atc gtt gtg gac aat aac ggc acg cta 643Val Arg Leu Lys Ala Ala Asp Ile Val Val Asp Asn Asn Gly Thr Leu

170 175 180gag gac ctt cat gct gaa gca agc aag ctg att gct gag att ctt agt 691Glu Asp Leu His Ala Glu Ala Ser Lys Leu Ile Ala Glu Ile Leu Ser

185 190 195cgc gtg aat tagcactaaa acatcgtcaa agt 723Arg Val Asn

200<210>732<211>200<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>732Met Leu Arg Ile Gly Leu Thr Gly Gly Ile Gly Ser Gly Lys Ser Thr 151015 Val Ala Asp Leu Leu Ser Ser Glu Gly Phe Leu Ile Val Asp Ala Asp

20 25 30Gln Val Ala Arg Asp Ile Val Glu Pro Gly Gln Pro Ala Leu Ala Glu

35 40 45Leu Ala Glu Ala Phe Gly Gln Asp Ile Leu Lys Pro Asp Gly Thr Leu

50 55 60Asp Arg Ala Gly Leu Ala Ala Lys Ala Phe Val Ser Glu Glu Gln Thr 65 70 75 80Ala Leu Leu Asn Ala Ile Thr His Pro Arg Ile Ala Glu Glu Ser Ala

85 90 95Arg Arg Phe Asn Glu Ala Glu Asp Gln Gly Ala Lys Val Ala Val Tyr

100 105 110Asp Met Pro Leu Leu Val Glu Lys Gly Leu Asp Arg Lys Met Asp Leu

115 120 125Val Val Val Val Asp Val Asp Val Glu Glu Arg Val Arg Arg Leu Val

130 135 140Glu Lys Arg Gly Leu Thr Glu Asp Asp Val Arg Arg Arg Ile Ala Ser145 150 155 160Gln Val Pro Asp Asp Val Arg Leu Lys Ala Ala Asp Ile Val Val Asp

165 170 175Asn Asn Gly Thr Leu Glu Asp Leu His Ala Glu Ala Ser Lys Leu Ile

180 185 190Ala Glu Ile Leu Ser Arg Val Asn

195200<210>733<211>1194<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1171)<223>RXN02802<400>733ccttcgccgc ctgctccgac ctcgccgacg ccgtcaaagc ccaggtcccg atctggaaag 60agcaaacgcg cctcgacggc tccaccgatt gggtcggcct gtg aaa aac ctc gac 115

Val Lys Asn Leu Asp

1 5atc gcc cgc tac cgc cgc caa att atg ctc ggc gaa atc ggc cag caa 163Ile Ala Arg Tyr Arg Arg Gln Ile Met Leu Gly Glu Ile Gly Gln Gln

10 15 20aaa caa caa tcg ctt ttc gac gct aag gtc tcc gtc atc ggc gca ggc 211Lys Gln Gln Ser Leu Phe Asp Ala Lys Val Ser Val Ile Gly Ala Gly

25 30 35ggc ctc ggg tca ccc gcc ctg ctc tac ctt gct ggc gct ggc gtc ggc 259Gly Leu Gly Ser Pro Ala Leu Leu Tyr Leu Ala Gly Ala Gly Val Gly

40 45 50cac atc cac atc att gac gat gac ctc gtc gac ctc tcc aac ctc cac 307His Ile His Ile Ile Asp Asp Asp Leu Val Asp Leu Ser Asn Leu His

55 60 65cgc cag gtc att cac acc acc gct ggc gtt gga aca ccc aag gcc gag 355Arg Gln Val Ile His Thr Thr Ala Gly Val Gly Thr Pro Lys Ala Glu 70 75 80 85tcc gcg cgc gaa gca atg ctg gca ctg aac cct tcc gtt aaa gtg acg 403Ser Ala Arg Glu Ala Met Leu Ala Leu Asn Pro Ser Val Lys Val Thr

90 95 100gtt tct gtc agg cga ctg gac tgg tca aat gca ctt tct gag ctg gca 451Val Ser Val Arg Arg Leu Asp Trp Ser Asn Ala Leu Ser Glu Leu Ala

105 110 115gat tcc gat gtg att ttg gat ggc tcc gat aac ttc gac acc cga cac 499Asp Ser Asp Val Ile Leu Asp Gly Ser Asp Asn Phe Asp Thr Arg His

120 125 130ctc gca tcc tgg gcc gcc gca aaa ctt ggc atc ccc cac gtc tgg gca 547Leu Ala Ser Trp Ala Ala Ala Lys Leu Gly Ile Pro His Val Trp Ala

135 140 145tcc atc ctg ggt ttc gac gcc caa ctc tcc gtc ttc cac gcc ggc cac 595Ser Ile Leu Gly Phe Asp Ala Gln Leu Ser Val Phe His Ala Gly His150 155 160 165ggc ccc atc tac gaa gac ctc ttc ccc acc ccg cca cca ccc gga tcc 643Gly Pro Ile Tyr Glu Asp Leu Phe Pro Thr Pro Pro Pro Pro Gly Ser

170 175 180gtc cca tca tgt tcc caa gca ggc gtt ttg ggt cca gtt gtc ggc gta 691Val Pro Ser Cys Ser Gln Ala Gly Val Leu Gly Pro Val Val Gly Val

185 190 195atg ggc tcc gcg atg gcc atg gaa gcc ctg aaa atc atc acc ggc gtg 739Met Gly Ser Ala Met Ala Met Glu Ala Leu Lys Ile Ile Thr Gly Val

200 205 210ggc aca ccc ttg atc gga aaa ctc ggc tac tac tcc tcc ctc gac ggc 787Gly Thr Pro Leu Ile Gly Lys Leu Gly Tyr Tyr Ser Ser Leu Asp Gly

215 220 225acc tgg gaa tac atc ccc gtc gtc ggt tcg ccg gag gtg ctg gaa cgg 835Thr Trp Glu Tyr Ile Pro Val Val Gly Ser Pro Glu Val Leu Glu Arg230 235 240 245gtg ctt ggg tct gct ggt gtt tcg ggg att tct ggc ggt ttt ggt gag 883Val Leu Gly Ser Ala Gly Val Ser Gly Ile Ser Gly Gly Phe Gly Glu

250 255 260gtg ctc gat gtt cct cga gtt tcc gcg ctg gtt gac ggc gtt tcg ctc 931Val Leu Asp Val Pro Arg Val Ser Ala Leu Val Asp Gly Val Ser Leu

265 270 275atc gac gtc cgc gaa ccc tcc gaa ttc tcc gcc tac tcc atc ccc ggc 979Ile Asp Val Arg Glu Pro Ser Glu Phe Ser Ala Tyr Ser Ile Pro Gly

280 285 290gcg cac aac acc cca ctg tcc gcc atc cgc gaa ggc gcc atc cca ccc 1027Ala His Asn Thr Pro Leu Ser Ala Ile Arg Glu Gly Ala Ile Pro Pro

295 300 305tcc gtt tcc gca ggt aaa gag gtt atc gtc tac tgc gca gct ggt gtc 1075Ser Val Ser Ala Gly Lys Glu Val Ile Val Tyr Cys Ala Ala Gly Val310 315 320 325cgc tcc gca caa gcc atc gca att tta gaa tcc gca ggc tac acc gga 1123Arg Ser Ala Gln Ala Ile Ala Ile Leu Glu Ser Ala Gly Tyr Thr Gly

330 335 340atg agc agc ctc gac ggc gga atc gaa ggc tgg cta gat tcc cta ggg 1171Met Ser Ser Leu Asp Gly Gly Ile Glu Gly Trp Leu Asp Ser Leu Gly

345350355 taaaaccaag gcgttgtgcc acc 1194<210>734<211>357<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>734Val Lys Asn Leu Asp Ile Ala Arg Tyr Arg Arg Gln Ile Met Leu Gly 151015 Glu Ile Gly Gln Gln Lys Gln Gln Ser Leu Phe Asp Ala Lys Val Ser

20 25 30Val Ile Gly Ala Gly Gly Leu Gly Ser Pro Ala Leu Leu Tyr Leu Ala

35 40 45Gly Ala Gly Val Gly His Ile His Ile Ile Asp Asp Asp Leu Val Asp

50 55 60Leu Ser Asn Leu His Arg Gln Val Ile His Thr Thr Ala Gly Val Gly 65 70 75 80Thr Pro Lys Ala Glu Ser Ala Arg Glu Ala Met Leu Ala Leu Asn Pro

85 9095Ser Val Lys Val Thr Val Ser Val Arg Arg Leu Asp Trp Ser Asn Ala

100 105 110Leu Ser Glu Leu Ala Asp Ser Asp Val Ile Leu Asp Gly Ser Asp Asn

115 120 125Phe Asp Thr Arg His Leu Ala Ser Trp Ala Ala Ala Lys Leu Gly Ile

130 135 140Pro His Val Trp Ala Ser Ile Leu Gly Phe Asp Ala Gln Leu Ser Val145 150 155 160Phe His Ala Gly His Gly Pro Ile Tyr Glu Asp Leu Phe Pro Thr Pro

165 170 175Pro Pro Pro Gly Ser Val Pro Ser Cys Ser Gln Ala Gly Val Leu Gly

180 185 190Pro Val Val Gly Val Met Gly Ser Ala Met Ala Met Glu Ala Leu Lys

195 200 205Ile Ile Thr Gly Val Gly Thr Pro Leu Ile Gly Lys Leu Gly Tyr Tyr

210 215 220Ser Ser Leu Asp Gly Thr Trp Glu Tyr Ile Pro Val Val Gly Ser Pro225 230 235 240Glu Val Leu Glu Arg Val Leu Gly Ser Ala Gly Val Ser Gly Ile Ser

245 250 255Gly Gly Phe Gly Glu Val Leu Asp Val Pro Arg Val Ser Ala Leu Val

260 265 270Asp Gly Val Ser Leu Ile Asp Val Arg Glu Pro Ser Glu Phe Ser Ala

275 280 285Tyr Ser Ile Pro Gly Ala His Asn Thr Pro Leu Ser Ala Ile Arg Glu

290 295 300Gly Ala Ile Pro Pro Ser Val Ser Ala Gly Lys Glu Val Ile Val Tyr305 310 315320Cys Ala Ala Gly Val Arg Ser Ala Gln Ala Ile Ala Ile Leu Glu Ser

325 330 335Ala Gly Tyr Thr Gly Met Ser Ser Leu Asp Gly Gly Ile Glu Gly Trp

340 345 350Leu Asp Ser Leu Gly

355<210>735<211>497<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(7). (474)<223>FRXA02802<400>735tccgcg atg gcc atg gaa gcc ctg aaa atc atc acc ggc gtg ggc aca ccc 51

Met Ala Met Glu Ala Leu Lys Ile Ile Thr Gly Val Gly Thr Pro

1 5 10 15ttg atc gga aaa ctc ggc tac tac tcc tcc ctc gac ggc acc tgg gaa 99Leu Ile Gly Lys Leu Gly Tyr Tyr Ser Ser Leu Asp Gly Thr Trp Glu

20 25 30tac atc ccc gtc gtc ggt tcg ccg gag gtg ctg gaa cgg gtg ctt ggg 147Tyr Ile Pro Val Val Gly Ser Pro Glu Val Leu Glu Arg Val Leu Gly

35 40 45tct gct ggt gtt tcg ggg att tct ggc ggt ttt ggt gag gtg ctc gat 195Ser Ala Gly Val Ser Gly Ile Ser Gly Gly Phe Gly Glu Val Leu Asp

50 55 60gtt cct cga gtt tcc gcg ctg gtt gac ggc gtt tcg ctc atc gac gtc 243Val Pro Arg Val Ser Ala Leu Val Asp Gly Val Ser Leu Ile Asp Val

65 70 75cgc gaa ccc tcc gaa ttc tcc gcc tac tcc atc ccc ggc gcg cac aac 291Arg Glu Pro Ser Glu Phe Ser Ala Tyr Ser Ile Pro Gly Ala His Asn 80 85 90 95acc cca ctg tcc gcc atc cgc gaa ggc gcc atc cca ccc tcc gtt tcc 339Thr Pro Leu Ser Ala IleArg Glu Gly Ala Ile Pro Pro Ser Val Ser

100 105 110gca ggt aaa gag gtt atc gtc tac tgc gca gct ggt gtc cgc tcc gca 387Ala Gly Lys Glu Val Ile Val Tyr Cys Ala Ala Gly Val Arg Ser Ala

115 120 125caa gcc atc gca att tta gaa tcc gca ggc tac acc gga atg agc agc 435Gln Ala Ile Ala Ile Leu Glu Ser Ala Gly Tyr Thr Gly Met Ser Ser

130 135 140ctc gac ggc gga atc gaa ggc tgg cta gat tcc cta ggg taaaaccaag 484Leu Asp Gly Gly Ile Glu Gly Trp Leu Asp Ser Leu Gly

145150155 gcgttgtgcc acc 497<210>736<211>156<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>736Met Ala Met Glu Ala Leu Lys Ile Ile Thr Gly Val Gly Thr Pro Leu 151015 Ile Gly Lys Leu Gly Tyr Tyr Ser Ser Leu Asp Gly Thr Trp Glu Tyr

20 25 30Ile Pro Val Val Gly Ser Pro Glu Val Leu Glu Arg Val Leu Gly Ser

35 40 45Ala Gly Val Ser Gly Ile Ser Gly Gly Phe Gly Glu Val Leu Asp Val

50 55 60Pro Arg Val Ser Ala Leu Val Asp Gly Val Ser Leu Ile Asp Val Arg 65 70 75 80Glu Pro Ser Glu Phe Ser Ala Tyr Ser Ile Pro Gly Ala His Asn Thr

85 90 95Pro Leu Ser Ala Ile Arg Glu Gly Ala Ile Pro Pro Ser Val Ser Ala

100 105 110Gly Lys Glu Val Ile Val Tyr Cys Ala Ala Gly Val Arg Ser Ala Gln

115 120 125Ala Ile Ala Ile Leu Glu Ser Ala Gly Tyr Thr Gly Met Ser Ser Leu

130135140 Asp Gly Gly Ile Glu Gly Trp Leu Asp Ser Leu Gly 145150155<210>737<211>535<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (535)<223>FRXA00438<400>737ccttcgccgc ctgctccgac ctcgccgacg ccgtcaaagc ccaggtcccg atctggaaag 60agcaaacgcg cctcgacggc tccaccgatt gggtcggcct gtg aaa aac ctc gac 115

Val Lys Asn Leu Asp

1 5atc gcc cgc tac cgc cgc caa att atg ctc ggc gaa atc ggc cag caa 163Ile Ala Arg Tyr Arg Arg Gln Ile Met Leu Gly Glu Ile Gly Gln Gln

10 15 20aaa caa caa tcg ctt ttc gac gct aag gtc tcc gtc atc ggc gca ggc 211Lys Gln Gln Ser Leu Phe Asp Ala Lys Val Ser Val Ile Gly Ala Gly

25 30 35ggc ctc ggg tca ccc gcc ctg ctc tac ctt gct ggc gct ggc gtc ggc 259Gly Leu Gly Ser Pro Ala Leu Leu Tyr Leu Ala Gly Ala Gly Val Gly

40 45 50cac atc cac atc att gac gat gac ctc gtc gac ctc tcc aac ctc cac 307His Ile His Ile Ile Asp Asp Asp Leu Val Asp Leu Ser Asn Leu His

55 60 65cgc cag gtc att cac acc acc gct ggc gtt gga aca ccc aag gcc gag 355Arg Gln Val Ile His Thr Thr Ala Gly Val Gly Thr Pro Lys Ala Glu 70 75 80 85tcc gcg cgc gaa gca atg ctg gca ctg aac cct tcc gtt aaa gtg acg 403Ser Ala Arg Glu Ala Met Leu Ala Leu Asn Pro Ser Val Lys Val Thr

90 95 100gtt tct gtc agg cga ctg gac tgg tca aat gca ctt tct gag ctggca 451Val Ser Val Arg Arg Leu Asp Trp Ser Asn Ala Leu Ser Glu Leu Ala

105 110 115gat tcc gat gtg att ttg gat ggc tcc gat aac ttc gac acc cga cac 499Asp Ser Asp Val Ile Leu Asp Gly Ser Asp Asn Phe Asp Thr Arg His

120 125 130ctc gca tcc tgg gcc gcc gca aaa ctt ggc atc ccc 535Leu Ala Ser Trp Ala Ala Ala Lys Leu Gly Ile Pro

135140145<210>738<211>145<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>738Val Lys Asn Leu Asp Ile Ala Arg Tyr Arg Arg Gln Ile Met Leu Gly 151015 Glu Ile Gly Gln Gln Lys Gln Gln Ser Leu Phe Asp Ala Lys Val Ser

20 25 30Val Ile Gly Ala Gly Gly Leu Gly Ser Pro Ala Leu Leu Tyr Leu Ala

35 40 45Gly Ala Gly Val Gly His Ile His Ile Ile Asp Asp Asp Leu Val Asp

50 55 60Leu Ser Asn Leu His Arg Gln Val Ile His Thr Thr Ala Gly Val Gly 65 70 75 80Thr Pro Lys Ala Glu Ser Ala Arg Glu Ala Met Leu Ala Leu Asn Pro

85 90 95Ser Val Lys Val Thr Val Ser Val Arg Arg Leu Asp Trp Ser Asn Ala

100 105 110Leu Ser Glu Leu Ala Asp Ser Asp Val Ile Leu Asp Gly Ser Asp Asn

115 120 125Phe Asp Thr Arg His Leu Ala Ser Trp Ala Ala Ala Lys Leu Gly Ile

130135140 Pro145<210>739<211>579<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (556)<223>RXN00437<400>739ttcatcatgg cgctgcccgg ctccacgggt gcggcgcgcg atgccaccgc tgtcctcgac 60ccactcattg atcacatcac tggaactctg caaggccacc atg aac act gac ccc 115

Met Asn Thr Asp Pro

1 5gct tac gtc gcc gaa caa acc ggc aaa ctc atc gac gct ttc ctc acc 163Ala Tyr Val Ala Glu Gln Thr Gly Lys Leu Ile Asp Ala Phe Leu Thr

10 15 20acc gac ccc ctc gaa ccg ctg ctc gac gcc gcc aaa aac ggc gtc tgc 211Thr Asp Pro Leu Glu Pro Leu Leu Asp Ala Ala Lys Asn Gly Val Cys

25 30 35aca gag gcg atg ggc gcg ctg gtc acc ttc gaa ggc atc gtc cgc gac 259Thr Glu Ala Met Gly Ala Leu Val Thr Phe Glu Gly Ile Val Arg Asp

40 45 50cac gac ggc ggc gcc cgc gtg acc tcc ctg acc tac acc gcg cat ccc 307His Asp Gly Gly Ala Arg Val Thr Ser Leu Thr Tyr Thr Ala His Pro

55 60 65acc gcg ccg cag gtc ctt tct gct gtc gcg gac tcc atc gtt gaa aaa 355Thr Ala Pro Gln Val Leu Ser Ala Val Ala Asp Ser Ile Val Glu Lys 70 75 80 85cac ccg cgc acc cgc ctc tgg acc gcg cac cgc acc ggc gcc ttg aaa 403His Pro Arg Thr Arg Leu Trp Thr Ala His Arg Thr Gly Ala Leu Lys

90 95 100atc ggt gac gcc gcc ttc ctc gtc gtc gcc gcc tcc gcc cac cgc gcc 451Ile Gly Asp Ala Ala Phe Leu Val Val Ala Ala Ser Ala His Arg Ala

105 110 115gac gcc ttc gcc gcc tgc tcc gac ctc gcc gac gcc gtc aaa gcc cag 499Asp Ala Phe Ala Ala Cys Ser Asp Leu Ala Asp Ala Val Lys Ala Gln

120 125 130gtc ccg atc tgg aaa gag caa acg cgc ctc gac ggc tcc acc gat tgg 547Val Pro Ile Trp Lys Glu Gln Thr Arg Leu Asp Gly Ser Thr Asp Trp

135140145 gtc ggc ctg tgaaaaacct cgacatcgcc cgc 579Val Gly Leu150<210>740<211>152<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>740Met Asn Thr Asp Pro Ala Tyr Val Ala Glu Gln Thr Gly Lys Leu Ile 151015 Asp Ala Phe Leu Thr Thr Asp Pro Leu Glu Pro Leu Leu Asp Ala Ala

20 25 30Lys Asn Gly Val Cys Thr Glu Ala Met Gly Ala Leu Val Thr Phe Glu

35 40 45Gly Ile Val Arg Asp His Asp Gly Gly Ala Arg Val Thr Ser Leu Thr

50 55 60Tyr Thr Ala His Pro Thr Ala Pro Gln Val Leu Ser Ala Val Ala Asp 65 70 75 80Ser Ile Val Glu Lys His Pro Arg Thr Arg Leu Trp Thr Ala His Arg

85 90 95Thr Gly Ala Leu Lys Ile Gly Asp Ala Ala Phe Leu Val Val Ala Ala

100 105 110Ser Ala His Arg Ala Asp Ala Phe Ala Ala Cys Ser Asp Leu Ala Asp

115 120 125Ala Val Lys Ala Gln Val Pro Ile Trp Lys Glu Gln Thr Arg Leu Asp

130135140 Gly Ser Thr Asp Trp Val Gly Leu 145150<210>741<211>383<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220>CDS<222>(1). (360)<223>FRXA00437<400>741aaa aac ggc gtc tgc aca gag gcg atg ggc gcg ctg gtc acc ttc gaa 48Lys Asn Gly Val Cys Thr Glu Ala Met Gly Ala Leu Val Thr Phe Glu 151015 ggc atc gtc cgc gac cac gac ggc ggc gcc cgc gtg acc tcc ctg acc 96Gly Ile Val Arg Asp His Asp Gly Gly Ala Arg Val Thr Ser Leu Thr

20 25 30tac acc gcg cat ccc acc gcg ccg cag gtc ctt tct gct gtc gcg gac 144Tyr Thr Ala His Pro Thr Ala Pro Gln Val Leu Ser Ala Val Ala Asp

35 40 45tcc atc gtt gaa aaa cac ccg cgc acc cgc ctc tgg acc gcg cac cgc 192Ser Ile Val Glu Lys His Pro Arg Thr Arg Leu Trp Thr Ala His Arg

50 55 60acc ggc gcc ttg aaa atc ggt gac gcc gcc ttc ctc gtc gtc gcc gcc 240Thr Gly Ala Leu Lys Ile Gly Asp Ala Ala Phe Leu Val Val Ala Ala 65 70 75 80tcc gcc cac cgc gcc gac gcc ttc gcc gcc tgc tcc gac ctc gcc gac 288Ser Ala His Arg Ala Asp Ala Phe Ala Ala Cys Ser Asp Leu Ala Asp

85 90 95gcc gtc aaa gcc cag gtc ccg atc tgg aaa gag caa acg cgc ctc gac 336Ala Val Lys Ala Gln Val Pro Ile Trp Lys Glu Gln Thr Arg Leu Asp

100 105 110ggc tcc acc gat tgg gtc ggc ctg tgaaaaacct cgacatcgcc cgc 383Gly Ser Thr Asp Trp Val Gly Leu

115120<210>742<211>120<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>742Lys Asn Gly Val Cys Thr Glu Ala Met Gly Ala Leu Val Thr Phe Glu 151015 Gly Ile Val Arg Asp His Asp Gly Gly Ala Arg Val Thr Ser Leu Thr

20 25 30Tyr Thr Ala His Pro Thr Ala Pro Gln Val Leu Ser Ala Val Ala Asp

35 40 45Ser Ile Val Glu Lys His Pro Arg Thr Arg Leu Trp Thr Ala His Arg

50 55 60Thr Gly Ala Leu Lys Ile Gly Asp Ala Ala Phe Leu Val Val Ala Ala 65 70 75 80Ser Ala His Arg Ala Asp Ala Phe Ala Ala Cys Ser Asp Leu Ala Asp

85 90 95Ala Val Lys Ala Gln Val Pro Ile Trp Lys Glu Gln Thr Arg Leu Asp

100 105 110Gly Ser Thr Asp Trp Val Gly Leu

115120<210>743<211>591<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<568)<223>RXN00439<400>743ctgccaccgc agactgtctg atcaggatcc cggcgcggac tacggtggag gaaaacgaca 60tcgttaagat ttacccattc aactaacagg agttaattta atg agc gag otc acc 115

Met Ser Glu Leu Thr

1 5cac gtt cga gca gac ggt tcc gca cat atg gtg gat gtg acg ggc aaa 163His Val Arg Ala Asp Gly Ser Ala His Met Val Asp Val Thr Gly Lys

10 15 20aat gaa aca tcg aga act gct gtt gcc gaa ggg ttt gtg aag atg agg 211Asn Glu Thr Ser Arg Thr Ala Val Ala Glu Gly Phe Val Lys Met Arg

25 30 35ggg gac gtc gta aag cag ctt ttt agt gct ggt ctg cct aaa ggc gac 259Gly Asp Val Val Lys Gln Leu Phe Ser Ala Gly Leu Pro Lys Gly Asp

40 45 50gcg cta cct gtg gcg cgg att gcg ggt atc atg ggt gcg aag aag acg 307Ala Leu Pro Val Ala Arg Ile Ala Gly Ile Met Gly Ala Lys Lys Thr

55 60 65ccg gac att atccct tta tgc cac ccg ttg ccg ctg ggc aaa att act 355Pro Asp Ile Ile Pro Leu Cys His Pro Leu Pro Leu Gly Lys Ile Thr 70 75 80 85gtg gat ttt ttt gag ctt act gat ggt gtt cgg att gag gct tcg gtg 403Val Asp Phe Phe Glu Leu Thr Asp Gly Val Arg Ile Glu Ala Ser Val

90 95 100aaa acg cgt ggg gtt act ggt gtg gaa atg gag gcg ttg acg gcc gtg 451Lys Thr Arg Gly Val Thr Gly Val Glu Met Glu Ala Leu Thr Ala Val

105 110 115agc act gcg gcg ctg acg gta tac gac atg atc aag gct gtg gat aag 499Ser Thr Ala Ala Leu Thr Val Tyr Asp Met Ile Lys Ala Val Asp Lys

120 125 130atg gcc gtg att gat ggc att cgt gtg ctg tcg aaa act ggc ggt aaa 547Met Ala Val Ile Asp Gly Ile Arg Val Leu Ser Lys Thr Gly Gly Lys

135140145 tct ggg gat tgg tct gtt cag tgacagctct ggttatcgtt gcg 591Ser Gly Asp Trp Ser Val Gln 150155<210>744<211>156<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>744Met Ser Glu Leu Thr His Val Arg Ala Asp Gly Ser Ala His Met Val 151015 Asp Val Thr Gly Lys Asn Glu Thr Ser Arg Thr Ala Val Ala Glu Gly

20 25 30Phe Val Lys Met Arg Gly Asp Val Val Lys Gln Leu Phe Ser Ala Gly

35 40 45Leu Pro Lys Gly Asp Ala Leu Pro Val Ala Arg Ile Ala Gly Ile Met

50 55 60Gly Ala Lys Lys Thr Pro Asp Ile Ile Pro Leu Cys His Pro Leu Pro 65 70 75 80Leu Gly Lys Ile Thr Val Asp Phe Phe Glu Leu Thr Asp Gly Val Arg

85 9095Ile Glu Ala Ser Val Lys Thr Arg Gly Val Thr Gly Val Glu Met Glu

100 105 110Ala Leu Thr Ala Val Ser Thr Ala Ala Leu Thr Val Tyr Asp Met Ile

115 120 125Lys Ala Val Asp Lys Met Ala Val Ile Asp Gly Ile Arg Val Leu Ser

130135140 Lys Thr Gly Gly Lys Ser Gly Asp Trp Ser Val Gln 145150155<210>745<211>218<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (195)<223>FRXA00439<400>745act gat ggt gtt cgg att gag gct tcg gtg aaa acg cgt ggg gtt act 48Thr Asp Gly Val Arg Ile Glu Ala Ser Val Lys Thr Arg Gly Val Thr 151015 ggt gtg gaa atg gag gcg ttg acg gcc gtg agc act gcg gcg ctg acg 96Gly Val Glu Met Glu Ala Leu Thr Ala Val Ser Thr Ala Ala Leu Thr

20 25 30gta tac gac atg atc aag gct gtg gat aag atg gcc gtg att gat ggc 144Val Tyr Asp Met Ile Lys Ala Val Asp Lys Met Ala Val Ile Asp Gly

35 40 45att cgt gtg ctg tcg aaa act ggc ggt aaa tct ggg gat tgg tct gtt 192Ile Arg Val Leu Ser Lys Thr Gly Gly Lys Ser Gly Asp Trp Ser Val

505560 cag tgacagctct ggttatcgtt gcg 218Gln 65<210>746<211>65<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>746Thr Asp Gly Val Arg Ile Glu Ala Ser Val Lys Thr Arg Gly Val Thr 151015 Gly Val Glu Met Glu Ala Leu Thr Ala Val Ser Thr Ala Ala Leu Thr

20 25 30Val Tyr Asp Met Ile Lys Ala Val Asp Lys Met Ala Val Ile Asp Gly

35 40 45Ile Arg Val Leu Ser Lys Thr Gly Gly Lys Ser Gly Asp TrpSer Val

505560 Gln 65<210>747<211>358<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (358)<223>FRXA00442<400>747ctgccaccgc agactgtctg atcaggatcc cggcgcggac tacggtggag gaaaacgaca 60tcgttaagat ttacccattc aactaacagg agttaattta atg agc gag ctc acc 115

Met Ser Glu Leu Thr

1 5cac gtt cga gca gac ggt tcc gca cat atg gtg gat gtg acg ggc aaa 163His Val Arg Ala Asp Gly Ser Ala His Met Val Asp Val Thr Gly Lys

10 15 20aat gaa aca tcg aga act gct gtt gcc gaa ggg ttt gtg aag atg agg 211Asn Glu Thr Ser Arg Thr Ala Val Ala Glu Gly Phe Val Lys Met Arg

25 30 35ggg gac gtc gta aag cag ctt ttt agt gct ggt ctg cct aaa ggg gac 259Gly Asp Val Val Lys Gln Leu Phe Ser Ala Gly Leu Pro Lys Gly Asp

40 45 50gcg cta cct gtg gcg cgg att gcg ggt atc atg ggt gcg aag aag acg 307Ala Leu Pro Val Ala Arg Ile Ala Gly Ile Met Gly Ala Lys Lys Thr

556065 ccg gac att atc cct tta tgc cac ccg ttg ccg ctg ggc aaa att act 355Pro Asp Ile Ile Pro Leu Cys His Pro Leu Pro Leu Gly Lys Ile Thr 70758085 gtg 358Val<210>748<211>86<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>748Met Ser Glu Leu Thr His Val Arg Ala Asp Gly Ser Ala His Met Val 151015 Asp Val Thr Gly Lys Asn Glu Thr Ser Arg Thr Ala Val Ala Glu Gly

20 25 30Phe Val Lys Met Arg Gly Asp Val Val Lys Gln Leu Phe Ser Ala Gly

35 40 45Leu Pro Lys Gly Asp Ala Leu Pro Val Ala Arg Ile Ala Gly Ile Met

50 55 60Gly Ala Lys Lys Thr Pro Asp Ile Ile Pro Leu Cys His Pro Leu Pro 65 70 75 80Leu Gly Lys Ile Thr Val

85<210>749<211>582<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (559)<223>RXA00440<400>749cggtatacga catgatcaag gctgtggata agatggccgt gattgatggc attcgtgtgc 60tgtcgaaaac tggcggtaaa tctggggatt ggtctgttca gtg aca gct ctg gtt 115

Val Thr Ala Leu Val

1 5atc gtt gcg tcc act cgc gcc gct gcc ggg gtg tat gag gat cgc tct 163Ile Val Ala Ser Thr Arg Ala Ala Ala Gly Val Tyr Glu Asp Arg Ser

10 15 20ggc cca att ttg gtg tcg tgg ctg cgt gca aaa ggt ttt gac aca ccc 211Gly Pro Ile Leu Val Ser Trp Leu Arg Ala Lys Gly Phe Asp Thr Pro

25 30 35gcc ccc gtg atc gtg gcg gac gcc aac ctg ccc gca ttc ctg gac gag 259Ala Pro Val Ile Val Ala Asp Ala Asn Leu Pro Ala Phe Leu Asp Glu

40 45 50ctg gaa ttt ccg cag gta gta ctt att tca ggc ggc acc gga ctc acg 307Leu Glu Phe Pro Gln Val Val Leu Ile Ser Gly Gly Thr Gly Leu Thr

55 60 65cct gat gac atc acc gtg gac act tta atc ccg cgc ctc gac aaa gaa 355Pro Asp Asp Ile Thr Val Asp Thr Leu Ile Pro Arg Leu Asp Lys Glu 70 75 80 85atc ccc ggc atc gcc cac gct ttt tgg aat tac agc atg gac gcc gtc 403Ile Pro Gly Ile Ala His Ala Phe Trp Asn Tyr Ser Met Asp Ala Val

90 95 100ccg acc gca gta ttg tcg cgc acc gtc gcg ggc acc atc ggc ggc agt 451Pro Thr Ala Val Leu Ser Arg Thr Val Ala Gly Thr Ile Gly Gly Ser

105 110 115ttc atc atg gcg ctg ccc ggc tcc acg ggt gcg gcg cgc gat gcc acc 499Phe Ile Met Ala Leu Pro Gly Ser Thr Gly Ala Ala Arg Asp Ala Thr

120 125 130gct gtc ctc gac cca ctc att gat cac atc act gga act ctg caa ggc 547Ala Val Leu Asp Pro Leu Ile Asp His Ile Thr Gly Thr Leu Gln Gly

135140145 cac cat gaa cac tgaccccgct tacgtcgccg aac 582His His Glu His150<210>750<211>153<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>750Val Thr Ala Leu Val Ile Val Ala Ser Thr Arg Ala Ala Ala Gly Val 151015 Tyr Glu Asp Arg Ser Gly Pro Ile Leu Val Ser Trp Leu Arg Ala Lys

20 25 30Gly Phe Asp Thr Pro Ala Pro Val Ile Val Ala Asp Ala Asn Leu Pro

35 40 45Ala Phe Leu Asp Glu Leu Glu Phe Pro Gln Val Val Leu Ile Ser Gly

50 55 60Gly Thr Gly Leu Thr Pro Asp Asp Ile Thr Val Asp Thr Leu Ile Pro 65 70 75 80Arg Leu Asp Lys Glu Ile Pro Gly Ile Ala His Ala Phe Trp Asn Tyr

85 90 95Ser Met Asp Ala Val Pro Thr Ala Val Leu Ser Arg Thr Val Ala Gly

100 105 110Thr Ile Gly Gly Ser Phe Ile Met Ala Leu Pro Gly Ser Thr Gly Ala

115 120 125Ala Arg Asp Ala Thr Ala Val Leu Asp Pro Leu Ile Asp His Ile Thr

130135140 Gly Thr Leu Gln Gly His His Glu His 145150<210>751<211>1287<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220>CDS<222>(101).)

Met Ser Arg Ser Pro

1 5gag caa cat ttg gca gaa att tca gcg ctg ctt ccc cca caa aag tcc 163Glu Gln His Leu Ala Glu Ile Ser Ala Leu Leu Pro Pro Gln Lys Ser

10 15 20acg ttc gtg aat ctg cgc gaa gcg ttg gga cgc cgc acg ttt tca gcg 211Thr Phe Val Asn Leu Arg Glu Ala Leu Gly Arg Arg Thr Phe Ser Ala

25 30 35gtc act gcg cag tgg gat tcg cca cgt ttt gat aat tcc caa atg gat 259Val Thr Ala Gln Trp Asp Ser Pro Arg Phe Asp Asn Ser Gln Met Asp

40 45 50ggc ttc gcg ctt ggc ccc tca cat ctt aac ggt ggc acc ttc gca gtc 307Gly Phe Ala Leu Gly Pro Ser His Leu Asn Gly Gly Thr Phe Ala Val

55 60 65ggt cca acc att ccc gct ggt cat gat cct gat cag tgg tac cca cga 355Gly Pro Thr Ile Pro Ala Gly His Asp Pro Asp Gln Trp Tyr Pro Arg 70 75 80 85ggc atc gaa aaa gac atc gcg ccg att atg acg ggt gcg cgc ctt cct 403Gly Ile Glu Lys Asp Ile Ala Pro Ile Met Thr Gly Ala Arg Leu Pro

90 95 100aaa aac acc gcc gcg atc att cct gtg gag aaa acc aca ccg gga aat 451Lys Asn Thr Ala Ala Ile Ile Pro Val Glu Lys Thr Thr ProGly Asn

105 110 115ttc gac gcc cca cag gta gaa atc ccc gcc acc ccg caa ggt cag ttc 499Phe Asp Ala Pro Gln Val Glu Ile Pro Ala Thr Pro Gln Gly Gln Phe

120 125 130ata cgg ttg cag ggt tcg gat att act gcc ggc gac gag atc att cca 547Ile Arg Leu Gln Gly Ser Asp Ile Thr Ala Gly Asp Glu Ile Ile Pro

135 140 145gca ggt acg gag ctt aac tcg gtg cac atc ggg gtg ttg gct agt cag 595Ala Gly Thr Glu Leu Asn Ser Val His Ile Gly Val Leu Ala Ser Gln150 155 160 165tcg atc aag agc att gaa gtc gca gca aag cca cgt gtc ctc atc atc 643Ser Ile Lys Ser Ile Glu Val Ala Ala Lys Pro Arg Val Leu Ile Ile

170 175 180acc ggc ggg tct gaa att tca gaa cag cac gga ccc gcc acg atc cct 691Thr Gly Gly Ser Glu Ile Ser Glu Gln His Gly Pro Ala Thr Ile Pro

185 190 195gat gcc aac ggc cct ctg ctt cgt tcc ctg tgc gcc cgc aac aat atc 739Asp Ala Asn Gly Pro Leu Leu Arg Ser Leu Cys Ala Arg Asn Asn Ile

200 205 210gag gtc atc gcg gga ctg cac acc aac gac gat cct gaa cga ctc cgc 787Glu Val Ile Ala Gly Leu His Thr Asn Asp Asp Pro Glu Arg Leu Arg

215 220 225ttt gaa ctg gaa aac gcc att gac cag tat caa ccg gat gtc atc atc 835Phe Glu Leu Glu Asn Ala Ile Asp Gln Tyr Gln Pro Asp Val Ile Ile230 235 240 245acc tct ggc ggt atc agc cac ggt aaa ttt gag gtg ttt agg cag atc 883Thr Ser Gly Gly Ile Ser His Gly Lys Phe Glu Val Phe Arg Gln Ile

250 255 260ctcgaa ggc acc ccg aac tcc tgg ttt gga cat gtc gat cag cag cct 931Leu Glu Gly Thr Pro Asn Ser Trp Phe Gly His Val Asp Gln Gln Pro

265 270 275ggc ggt cct caa ggc atc tcc act ttt gct gaa act cct gtc att tca 979Gly Gly Pro Gln Gly Ile Ser Thr Phe Ala Glu Thr Pro Val Ile Ser

280 285 290ctt ccc gga aat ccg att tcc acc ttg gtg agt ttc aca ctt ttg gtc 1027Leu Pro Gly Asn Pro Ile Ser Thr Leu Val Ser Phe Thr Leu Leu Val

295 300 305gcg cca gcg ctc aac cgc cag ccg ctc cgc cac ctc gat gcc cgc atc 1075Ala Pro Ala Leu Asn Arg Gln Pro Leu Arg His Leu Asp Ala Arg Ile310 315 320 325acc gct ccg gtc cag ggc ttg caa gac aat cgc gag caa ttc ctt cgc 1123Thr Ala Pro Val Gln Gly Leu Gln Asp Asn Arg Glu Gln Phe Leu Arg

330 335 340ggc acc atc agt tac cgc aac ggg cca cgt cct cgc cac gcc tct cct 1171Gly Thr Ile Ser Tyr Arg Asn Gly Pro Arg Pro Arg His Ala Ser Pro

345 350 355ggg cac cag ttc cca cct gct ggt tca agc tgc cac cgc aga ctg tct 1219Gly His Gln Phe Pro Pro Ala Gly Ser Ser Cys His Arg Arg Leu Ser

360 365 370gat cag gat ccc ggc gcg gac tac ggt gga gga aaa cga cat cgt 1264Asp Gln Asp Pro Gly Ala Asp Tyr Gly Gly Gly Lys Arg His Arg

375380385 taagatttac ccattcaact aac 1287<210>752<211>388<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>752Met Ser Arg Ser Pro Glu Gln His Leu Ala Glu Ile Ser Ala Leu Leu 151015 Pro Pro Gln Lys Ser Thr Phe Val Asn Leu Arg Glu Ala Leu Gly Arg

20 25 30Arg Thr Phe Ser Ala Val Thr Ala Gln Trp Asp Ser Pro Arg Phe Asp

35 40 45Asn Ser Gln Met Asp Gly Phe Ala Leu Gly Pro Ser His Leu Asn Gly

50 55 60Gly Thr Phe Ala Val Gly Pro Thr Ile Pro Ala Gly His Asp Pro Asp 65 70 75 80Gln Trp Tyr Pro Arg Gly Ile Glu Lys Asp Ile Ala Pro Ile Met Thr

85 90 95Gly Ala Arg Leu Pro Lys Asn Thr Ala Ala Ile Ile Pro Val Glu Lys

100 105 110Thr Thr Pro Gly Asn Phe Asp Ala Pro Gln Val Glu Ile Pro Ala Thr

115 120 125Pro Gln Gly Gln Phe Ile Arg Leu Gln Gly Ser Asp Ile Thr Ala Gly

130 135 140Asp Glu Ile Ile Pro Ala Gly Thr Glu Leu Asn Ser Val His Ile Gly145 150 155 160Val Leu Ala Ser Gln Ser Ile Lys Ser Ile Glu Val Ala Ala Lys Pro

165 170 175Arg Val Leu Ile Ile Thr Gly Gly Ser Glu Ile Ser Glu Gln His Gly

180 185 190Pro Ala Thr Ile Pro Asp Ala Asn Gly Pro Leu Leu Arg Ser Leu Cys

195 200 205Ala Arg Asn Asn Ile Glu Val Ile Ala Gly Leu His Thr Asn Asp Asp

210 215 220Pro Glu Arg Leu Arg Phe Glu Leu Glu Asn Ala Ile Asp Gln Tyr Gln225 230 235 240Pro Asp Val Ile Ile Thr Ser Gly Gly Ile Ser His Gly Lys Phe Glu

245 250 255Val Phe Arg Gln Ile Leu Glu Gly Thr Pro Asn Ser Trp Phe Gly His

260 265 270Val Asp Gln Gln Pro Gly Gly Pro Gln Gly Ile Ser Thr Phe Ala Glu

275 280 285Thr Pro Val Ile Ser Leu Pro Gly Asn Pro Ile Ser Thr Leu Val Ser

290 295 300Phe Thr Leu Leu Val Ala Pro Ala Leu Asn Arg Gln Pro Leu Arg His305 310 315 320Leu Asp Ala Arg Ile Thr Ala Pro Val Gln Gly Leu Gln Asp Asn Arg

325 330 335Glu Gln Phe Leu Arg Gly Thr Ile Ser Tyr Arg Asn Gly Pro Arg Pro

340 345 350Arg His Ala Ser Pro Gly His Gln Phe Pro Pro Ala Gly Ser Ser Cys

355 360 365His Arg Arg Leu Ser Asp Gln Asp Pro Gly Ala Asp Tyr Gly Gly Gly

370375380 Lys Arg His Arg385<210>753<211>815<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (792)<223>FRXA00441<400>753atc ccc gcc acc ccg caa ggt cag ttc ata cgg ttg cag ggt tcg gat 48Ile Pro Ala Thr Pro Gln Gly Gln Phe Ile Arg Leu Gln Gly Ser Asp 151015 att act gcc ggc gac gag atc att cca gca ggt acg gag ctt aac tcg 96Ile Thr Ala Gly Asp Glu Ile Ile Pro Ala Gly Thr Glu Leu Asn Ser

20 25 30gtg cac atc ggg gtg ttg gct agt cag tcg atc aag agc att gaa gtc 144Val His Ile Gly Val Leu Ala Ser Gln Ser Ile Lys Ser Ile Glu Val

35 40 45gca gca aag cca cgt gtc ctc atc atc acc ggc ggg tct gaa att tca 192Ala Ala Lys Pro Arg Val Leu Ile Ile Thr Gly Gly Ser Glu Ile Ser

50 55 60gaa cag cac gga ccc gcc acg atc cct gat gcc aac ggc cct ctg ctt 240Glu Gln His Gly Pro Ala Thr Ile Pro Asp Ala Asn Gly Pro Leu Leu 65 70 75 80cgt tcc ctg tgc gcc cgc aac aat atc gag gtc atc gcg gga ctg cac 288Arg Ser Leu Cys Ala Arg Asn Asn Ile Glu Val Ile Ala Gly Leu His

85 90 95acc aac gac gat cct gaa cga ctc cgc ttt gaa ctg gaa aac gcc att 336Thr Asn Asp Asp Pro Glu Arg Leu Arg Phe Glu Leu Glu Asn Ala Ile

100 105 110gac cag tat caa ccg gat gtc atc atc acc tct ggc ggt atc agc cac 384Asp Gln Tyr Gln Pro Asp Val Ile Ile Thr Ser Gly Gly Ile Ser His

115 120 125ggt aaa ttt gag gtg ttt agg cag atc ctc gaa ggc acc ccg aac tcc 432Gly Lys Phe Glu Val Phe Arg Gln Ile Leu Glu Gly Thr Pro Asn Ser

130 135 140tgg ttt gga cat gtc gat cag cag cct ggc ggt cct caa ggc atc tcc 480Trp Phe Gly His Val Asp Gln Gln Pro Gly Gly Pro Gln Gly Ile Ser145 150 155 160act ttt gct gaa act cct gtc att tca ctt ccc gga aat ccg att tcc 528Thr Phe Ala Glu Thr Pro Val Ile Ser Leu Pro Gly Asn Pro Ile Ser

165 170 175acc ttg gtg agt ttc aca ctt ttg gtc gcg cca gcg ctc aac cgc cag 576Thr Leu Val Ser Phe Thr Leu Leu Val Ala Pro Ala Leu Asn Arg Gln

180 185 190ccg ctc cgc cac ctc gat gcc cgc atc acc gct ccg gtc cag ggc ttg 624Pro Leu Arg His Leu Asp Ala Arg Ile Thr Ala Pro Val Gln Gly Leu

195 200 205caa gac aat cgc gag caa ttc ctt cgc ggc acc atc agt tac cgc aac 672Gln Asp Asn Arg Glu Gln Phe Leu Arg Gly Thr Ile Ser Tyr Arg Asn

210 215 220ggg cca cgt cct cgc cac gcc tct cct ggg cac cag ttc cca cct gct 720Gly Pro Arg Pro Arg His Ala Ser Pro Gly His Gln Phe Pro Pro Ala225 230 235 240ggt tca agc tgc cac cgc aga ctg tct gat cag gat ccc ggc gcg gac 768Gly Ser Ser Cys His Arg Arg Leu Ser Asp Gln Asp Pro Gly Ala Asp

245 250 255tac ggt gga gga aaa cga cat cgt taagatttac ccattcaact aac 815Tyr Gly Gly Gly Lys Arg His Arg

260<210>754<211>264<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>754Ile Pro Ala Thr Pro Gln Gly Gln Phe Ile Arg Leu Gln Gly Ser Asp 151015 Ile Thr Ala Gly Asp Glu Ile Ile Pro Ala Gly Thr Glu Leu Asn Ser

20 25 30Val His Ile Gly Val Leu Ala Ser Gln Ser Ile Lys Ser Ile Glu Val

35 40 45Ala Ala Lys Pro Arg Val Leu Ile Ile Thr Gly Gly Ser Glu Ile Ser

50 55 60Glu Gln His Gly Pro Ala Thr Ile Pro Asp Ala Asn Gly Pro Leu Leu 65 70 75 80Arg Ser Leu Cys Ala Arg Asn Asn Ile Glu Val Ile Ala Gly Leu His

85 90 95Thr Asn Asp Asp Pro Glu Arg Leu Arg Phe Glu Leu Glu Asn Ala Ile

100 105 110Asp Gln Tyr Gln Pro Asp Val Ile Ile Thr Ser Gly Gly Ile Ser His

115 120 125Gly Lys Phe Glu Val Phe Arg Gln Ile Leu Glu Gly Thr Pro Asn Ser

130 135 140Trp Phe Gly His Val Asp Gln Gln Pro Gly Gly Pro Gln Gly Ile Ser145 150 155 160Thr Phe Ala Glu Thr Pro Val Ile Ser Leu Pro Gly Asn Pro Ile Ser

165 170 175Thr Leu Val Ser Phe Thr Leu Leu Val Ala Pro Ala Leu Asn Arg Gln

180 185 190Pro Leu Arg His Leu Asp Ala Arg Ile Thr Ala Pro Val Gln Gly Leu

195 200 205Gln Asp Asn Arg Glu Gln Phe Leu Arg Gly Thr Ile Ser Tyr Arg Asn

210 215 220Gly Pro Arg Pro Arg His Ala Ser Pro Gly His Gln Phe Pro Pro Ala225 230 235 240Gly Ser Ser Cys His Arg Arg Leu Ser Asp Gln Asp Pro Gly Ala Asp

245 250 255Tyr Gly Gly Gly Lys Arg His Arg

260<210>755<211>2358<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (2335)<223>RXN02085<400>755cacccggtga tttcgcgaac cttgaaacat cgtcagaaga ttgccgtgcg tcctagccgg 60gatccgcacg ttcggctcaa gcagaaagtc tttaactcac atg act tcc aac ttt 115

Met Thr Ser Asn Phe

1 5tct tcc act gtc gct ggt ctt cct cgc atc gga gcg aag cgt gaa ctg 163Ser Ser Thr Val Ala Gly Leu Pro Arg Ile Gly Ala Lys Arg Glu Leu

10 1520aag ttc gcg ctc gaa ggc tac tgg aat gga tca att gaa ggt cgc gaa 211Lys Phe Ala Leu Glu Gly Tyr Trp Asn Gly Ser Ile Glu Gly Arg Glu

25 30 35ctt gcg cag acc gcc cgc caa ttg gtc aac act gca tcg gat tct ttg 259Leu Ala Gln Thr Ala Arg Gln Leu Val Asn Thr Ala Ser Asp Ser Leu

40 45 50tct gga ttg gat tcc gtt ccg ttt gca gga cgt tcc tac tac gac gca 307Ser Gly Leu Asp Ser Val Pro Phe Ala Gly Arg Ser Tyr Tyr Asp Ala

55 60 65atg ctc gat acc gcc gct att ttg ggt gtg ctg ccg gag cgt ttt gat 355Met Leu Asp Thr Ala Ala Ile Leu Gly Val Leu Pro Glu Arg Phe Asp 70 75 80 85gac atc gct gat cat gaa aac gat ggt ctc cca ctg tgg att gac cgc 403Asp Ile Ala Asp His Glu Asn Asp Gly Leu Pro Leu Trp Ile Asp Arg

90 95 100tac ttt ggc gct gct cgc ggt act gag acc ctg cct gca cag gca atg 451Tyr Phe Gly Ala Ala Arg Gly Thr Glu Thr Leu Pro Ala Gln Ala Met

105 110 115acc aag tgg ttt gat acc aac tac cac tac ctc gtg ccg gag ttg tct 499Thr Lys Trp Phe Asp Thr Asn Tyr His Tyr Leu Val Pro Glu Leu Ser

120 125 130gcg gat aca cgt ttc gtt ttg gat gcg tcc gcg ctg att gag gat ctc 547Ala Asp Thr Arg Phe Val Leu Asp Ala Ser Ala Leu Ile Glu Asp Leu

135 140 145cgt tgc cag cag gtt cgt ggc gtt aat gcc cgc cct gtt ctg gtt ggt 595Arg Cys Gln Gln Val Arg Gly Val Asn Ala Arg Pro Val Leu Val Gly150 155 160 165cca ctg act ttc ctt tcc ctt gct cgc acc act gat ggt tcc aat cct 643Pro Leu Thr Phe Leu Ser Leu AlaArg Thr Thr Asp Gly Ser Asn Pro

170 175 180ttg gat cac ctg cct gca ctg ttt gag gtc tac gag cgc ctc atc aag 691Leu Asp His Leu Pro Ala Leu Phe Glu Val Tyr Glu Arg Leu Ile Lys

185 190 195tct ttc gat act gag tgg gtt cag atc gat gag cct gcg ttg gtc acc 739Ser Phe Asp Thr Glu Trp Val Gln Ile Asp Glu Pro Ala Leu Val Thr

200 205 210gat gtt gct cct gag gtt ttg gag cag gtc cgc gct ggt tac acc act 787Asp Val Ala Pro Glu Val Leu Glu Gln Val Arg Ala Gly Tyr Thr Thr

215 220 225ttg gct aag cgc gat ggc gtg ttt gtc aat act tac ttc ggc tct ggc 835Leu Ala Lys Arg Asp Gly Val Phe Val Asn Thr Tyr Phe Gly Ser Gly230 235 240 245gat cag gcg ctg aac act ctt gcg ggc atc ggc ctt ggc gcg att ggc 883Asp Gln Ala Leu Asn Thr Leu Ala Gly Ile Gly Leu Gly Ala Ile Gly

250 255 260gtt gac ttg gtc acc cat ggc gtc act gag ctt gct gcg tgg aag ggt 931Val Asp Leu Val Thr His Gly Val Thr Glu Leu Ala Ala Trp Lys Gly

265 270 275gag gag ctg ctg gtt gcg ggc atc gtt gat ggt cgt aac att tgg cgc 979Glu Glu Leu Leu Val Ala Gly Ile Val Asp Gly Arg Asn Ile Trp Arg

280 285 290acc gac ctg tgt gct gct ctt gct tcc ctg aag cgc ctg gca gct cgc 1027Thr Asp Leu Cys Ala Ala Leu Ala Ser Leu Lys Arg Leu Ala Ala Arg

295 300 305ggc cca atc gca gtg tct acc tct tgt tca ctg ctg cac gtt cct tac 1075Gly Pro Ile Ala Val Ser Thr Ser Cys Ser Leu Leu His Val Pro Tyr310 315 320 325acc ctc gag gct gag aac att gag cct gag gtc cgc gac tgg ctt gcc 1123Thr Leu Glu Ala Glu Asn Ile Glu Pro Glu Val Arg Asp Trp Leu Ala

330 335 340ttc ggc tcg gag aag atc acc gag gtc aag ctg ctt gcc gac gcc cta 1171Phe Gly Ser Glu Lys Ile Thr Glu Val Lys Leu Leu Ala Asp Ala Leu

345 350 355gcc ggc aac atc gac gcg gct gcg ttc gat gcg gcg tcc gca gca att 1219Ala Gly Asn Ile Asp Ala Ala Ala Phe Asp Ala Ala Ser Ala Ala Ile

360 365 370gct tct cga cgc acc tcc cca cgc acc gca cca atc acg cag gaa ctc 1267Ala Ser Arg Arg Thr Ser Pro Arg Thr Ala Pro Ile Thr Gln Glu Leu

375 380 385cct ggc cgt agc cgt gga tcc ttc gac act cgt gtt acg ctg cag gag 1315Pro Gly Arg Ser Arg Gly Ser Phe Asp Thr Arg Val Thr Leu Gln Glu390 395 400 405aag tca ctg gag ctt cca gct ctg cca acc acc acc att ggt tct ttc 1363Lys Ser Leu Glu Leu Pro Ala Leu Pro Thr Thr Thr Ile Gly Ser Phe

410 415 420cca cag acc cca tcc att cgt tct gct cgc gct cgt ctg cgc aag gaa 1411Pro Gln Thr Pro Ser Ile Arg Ser Ala Arg Ala Arg Leu Arg Lys Glu

425 430 435tcc atc act ttg gag cag tac gaa gag gca atg cgc gaa gaa atc gat 1459Ser Ile Thr Leu Glu Gln Tyr Glu Glu Ala Met Arg Glu Glu Ile Asp

440 445 450ctg gtc atc gcc aag cag gaa gaa ctt ggt ctt gat gtg ttg gtt cac 1507Leu Val Ile Ala Lys Gln Glu Glu Leu Gly Leu Asp Val Leu Val His

455 460 465ggt gag cca gag cgc aac gac atg gtt cag tac ttc tct gaa ctt ctc 1555Gly Glu Pro Glu Arg Asn Asp Met Val Gln Tyr Phe Ser Glu Leu Leu470 475 480 485gac ggt ttc ctc tca acc gcc aac ggc tgg gtc caa agc tac ggc tcc 1603Asp Gly Phe Leu Ser Thr Ala Asn Gly Trp Val Gln Ser Tyr Gly Ser

490 495 500cgc tgt gtt cgt cct cca gtg ttg ttc gga aac gtt tcc cgc cca gcg 1651Arg Cys Val Arg Pro Pro Val Leu Phe Gly Asn Val Ser Arg Pro Ala

505 510 515cca atg act gtc aag tgg ttc cag tac gca cag agc ctg acc cag aag 1699Pro Met Thr Val Lys Trp Phe Gln Tyr Ala Gln Ser Leu Thr Gln Lys

520 525 530cat gtc aag gga atg ctc acc ggt cca gtc acc atc ctt gca tgg tcc 1747His Val Lys Gly Met Leu Thr Gly Pro Val Thr Ile Leu Ala Trp Ser

535 540 545ttc gtt cgc gat gat cag ccg ctg gct acc act gct gac cag gtt gca 1795Phe Val Arg Asp Asp Gln Pro Leu Ala Thr Thr Ala Asp Gln Val Ala550 555 560 565ctg gca ctg cgc gat gaa att aac gat ctc atc gag gct ggc gcg aag 1843Leu Ala Leu Arg Asp Glu Ile Asn Asp Leu Ile Glu Ala Gly Ala Lys

570 575 580atc atc cag gtg gat gag cct gcg att cgt gaa ctg ttg ccg cta cga 1891Ile Ile Gln Val Asp Glu Pro Ala Ile Arg Glu Leu Leu Pro Leu Arg

585 590 595gac gtc gat aag cct gcc tac ctg cag tgg tcc gtg gac tcc ttc cgc 1939Asp Val Asp Lys Pro Ala Tyr Leu Gln Trp Ser Val Asp Ser Phe Arg

600 605 610ctg gcg act gcc ggc gca ccc gac gac gtc caa atc cac acc cac atg 1987Leu Ala Thr Ala Gly Ala Pro Asp Asp Val Gln Ile His Thr HisMet

615 620 625tgc tac tcc gag ttc aac gaa gtg atc tcc tcg gtc atc gcg ttg gat 2035Cys Tyr Ser Glu Phe Asn Glu Val Ile Ser Ser Val Ile Ala Leu Asp630 635 640 645gcc gat gtc acc acc atc gaa gca gca cgt tcc gac atg cag gtc ctc 2083Ala Asp Val Thr Thr Ile Glu Ala Ala Arg Ser Asp Met Gln Val Leu

650 655 660gct gct ctg aaa tct tcc ggc ttc gag ctc ggc gtc gga cct ggt gtg 2131Ala Ala Leu Lys Ser Ser Gly Phe Glu Leu Gly Val Gly Pro Gly Val

665 670 675tgg gat atc cac tcc ccg cgc gtt cct tcc gcg cag aaa gtg gac ggt 2179Trp Asp Ile His Ser Pro Arg Val Pro Ser Ala Gln Lys Val Asp Gly

680 685 690ctc ctc gag gct gca ctg cag tcc gtg gat cct cgc cag ctg tgg gtc 2227Leu Leu Glu Ala Ala Leu Gln Ser Val Asp Pro Arg Gln Leu Trp Val

695 700 705aac cca gac tgt ggt ctg aag acc cgt gga tgg cca gaa gtg gaa gct 2275Asn Pro Asp Cys Gly Leu Lys Thr Arg Gly Trp Pro Glu Val Glu Ala710 715 720 725tcc cta aag gtt ctc gtt gag tcc gct aag cag gct cgt gag aaa atc 2323Ser Leu Lys Val Leu Val Glu Ser Ala Lys Gln Ala Arg Glu Lys Ile

730 735 740gga gca act atc taaattgggt taccgctagg aac 2358Gly Ala Thr Ile

745<210>756<211>745<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>756Met Thr Ser Asn Phe Ser Ser Thr Val Ala Gly Leu Pro Arg Ile Gly 151015 Ala Lys Arg Glu Leu Lys Phe Ala Leu Glu Gly Tyr Trp Asn Gly Ser

2025 30Ile Glu Gly Arg Glu Leu Ala Gln Thr Ala Arg Gln Leu Val Asn Thr

35 40 45Ala Ser Asp Ser Leu Ser Gly Leu Asp Ser Val Pro Phe Ala Gly Arg

50 55 60Ser Tyr Tyr Asp Ala Met Leu Asp Thr Ala Ala Ile Leu Gly Val Leu 65 70 75 80Pro Glu Arg Phe Asp Asp Ile Ala Asp His Glu Asn Asp Gly Leu Pro

85 90 95Leu Trp Ile Asp Arg Tyr Phe Gly Ala Ala Arg Gly Thr Glu Thr Leu

100 105 110Pro Ala Gln Ala Met Thr Lys Trp Phe Asp Thr Asn Tyr His Tyr Leu

115 120 125Val Pro Glu Leu Ser Ala Asp Thr Arg Phe Val Leu Asp Ala Ser Ala

130 135 140Leu Ile Glu Asp Leu Arg Cys Gln Gln Val Arg Gly Val Asn Ala Arg145 150 155 160Pro Val Leu Val Gly Pro Leu Thr Phe Leu Ser Leu Ala Arg Thr Thr

165 170 175Asp Gly Ser Asn Pro Leu Asp His Leu Pro Ala Leu Phe Glu Val Tyr

180 185 190Glu Arg Leu Ile Lys Ser Phe Asp Thr Glu Trp Val Gln Ile Asp Glu

195 200 205Pro Ala Leu Val Thr Asp Val Ala Pro Glu Val Leu Glu Gln Val Arg

210 215 220Ala Gly Tyr Thr Thr Leu Ala Lys Arg Asp Gly Val Phe Val Asn Thr225 230 235 240Tyr Phe Gly Ser Gly Asp Gln Ala Leu Asn Thr Leu Ala Gly Ile Gly

245250 255Leu Gly Ala Ile Gly Val Asp Leu Val Thr His Gly Val Thr Glu Leu

260 265 270Ala Ala Trp Lys Gly Glu Glu Leu Leu Val Ala Gly Ile Val Asp Gly

275 280 285Arg Asn Ile Trp Arg Thr Asp Leu Cys Ala Ala Leu Ala Ser Leu Lys

290 295 300Arg Leu Ala Ala Arg Gly Pro Ile Ala Val Ser Thr Ser Cys Ser Leu305 310 315 320Leu His Val Pro Tyr Thr Leu Glu Ala Glu Asn Ile Glu Pro Glu Val

325 330 335Arg Asp Trp Leu Ala Phe Gly Ser Glu Lys Ile Thr Glu Val Lys Leu

340 345 350Leu Ala Asp Ala Leu Ala Gly Asn Ile Asp Ala Ala Ala Phe Asp Ala

355 360 365Ala Ser Ala Ala Ile Ala Ser Arg Arg Thr Ser Pro Arg Thr Ala Pro

370 375 380Ile Thr Gln Glu Leu Pro Gly Arg Ser Arg Gly Ser Phe Asp Thr Arg385 390 395 400Val Thr Leu Gln Glu Lys Ser Leu Glu Leu Pro Ala Leu Pro Thr Thr

405 410 415Thr Ile Gly Ser Phe Pro Gln Thr Pro Ser Ile Arg Ser Ala Arg Ala

420 425 430Arg Leu Arg Lys Glu Ser Ile Thr Leu Glu Gln Tyr Glu Glu Ala Met

435 440 445Arg Glu Glu Ile Asp Leu Val Ile Ala Lys Gln Glu Glu Leu Gly Leu

450 455 460 Asp Val Leu Val His Gly Glu Pro Glu Arg Asn Asp Met Val Gln Tyr465470 475 480Phe Ser Glu Leu Leu Asp Gly Phe Leu Ser Thr Ala Asn Gly Trp Val

485 490 495Gln Ser Tyr Gly Ser Arg Cys Val Arg Pro Pro Val Leu Phe Gly Asn

500 505 510Val Ser Arg Pro Ala Pro Met Thr Val Lys Trp Phe Gln Tyr Ala Gln

515 520 525Ser Leu Thr Gln Lys His Val Lys Gly Met Leu Thr Gly Pro Val Thr

530 535 540Ile Leu Ala Trp Ser Phe Val Arg Asp Asp Gln Pro Leu Ala Thr Thr545 550 555 560Ala Asp Gln Val Ala Leu Ala Leu Arg Asp Glu Ile Asn Asp Leu Ile

565 570 575Glu Ala Gly Ala Lys Ile Ile Gln Val Asp Glu Pro Ala Ile Arg Glu

580 585 590Leu Leu Pro Leu Arg Asp Val Asp Lys Pro Ala Tyr Leu Gln Trp Ser

595 600 605Val Asp Ser Phe Arg Leu Ala Thr Ala Gly Ala Pro Asp Asp Val Gln

610 615 620Ile His Thr His Met Cys Tyr Ser Glu Phe Asn Glu Val Ile Ser Ser625 630 635 640Val Ile Ala Leu Asp Ala Asp Val Thr Thr Ile Glu Ala Ala Arg Ser

645 650 655Asp Met Gln Val Leu Ala Ala Leu Lys Ser Ser Gly Phe Glu Leu Gly

660 665 670Val Gly Pro Gly Val Trp Asp Ile His Ser Pro Arg Val Pro Ser Ala

675 680 685Gln Lys Val Asp Gly Leu Leu Glu Ala Ala Leu Gln Ser Val Asp Pro

690 695 700Arg Gln Leu Trp Val Asn Pro Asp Cys Gly Leu Lys Thr Arg Gly Trp705 710 715 720Pro Glu Val Glu Ala Ser Leu Lys Val Leu Val Glu Ser Ala Lys Gln

725 730 735Ala Arg Glu Lys Ile Gly Ala Thr Ile

740745<210>757<211>1923<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<1900><223>FRXA02085<400>757cacccggtga tttcgcgaac cttgaaacat cgtcagaaga ttgccgtgcg tcctagccgg 60gatccgcacg ttcggctcaa gcagaaagtc tttaactcac atg act tcc aac ttt 115

Met Thr Ser Asn Phe

1 5tct tcc act gtc gct ggt ctt cct cgc atc gga gcg aag cgt gaa ctg 163Ser Ser Thr Val Ala Gly Leu Pro Arg Ile Gly Ala Lys Arg Glu Leu

10 15 20aag ttc gcg ctc gaa ggc tac tgg aat gga tca att gaa ggt cgc gaa 211Lys Phe Ala Leu Glu Gly Tyr Trp Asn Gly Ser Ile Glu Gly Arg Glu

25 30 35ctt gcg cag acc gcc cgc caa ttg gtc aac act gca tcg gat tct ttg 259Leu Ala Gln Thr Ala Arg Gln Leu Val Asn Thr Ala Ser Asp Ser Leu

40 45 50tct gga ttg gat tcc gtt ccg ttt gca gga cgt tcc tac tac gac gca 307Ser Gly Leu Asp Ser Val Pro Phe Ala Gly Arg Ser Tyr Tyr Asp Ala

55 60 65atg ctc gat acc gcc gct att ttg ggt gtg ctg ccg gag cgt ttt gat 355Met Leu Asp Thr Ala Ala Ile Leu Gly Val Leu Pro Glu Arg Phe Asp 70 7580 85gac atc gct gat cat gaa aac gat ggt ctc cca ctg tgg att gac cgc 403 Asp Ile Ala Asp His Glu Asn Asp Gly Leu Pro Leu Trp Ile Asp Arg

90 95 100tac ttt ggc gct gct cgc ggt act gag acc ctg cct gca cag gca atg 451Tyr Phe Gly Ala Ala Arg Gly Thr Glu Thr Leu Pro Ala Gln Ala Met

105 110 115acc aag tgg ttt gat acc aac tac cac tac ctc gtg ccg gag ttg tct 499Thr Lys Trp Phe Asp Thr Asn Tyr His Tyr Leu Val Pro Glu Leu Ser

120 125 130gcg gat aca cgt ttc gtt ttg gat gcg tcc gcg ctg att gag gat ctc 547Ala Asp Thr Arg Phe Val Leu Asp Ala Ser Ala Leu Ile Glu Asp Leu

135 140 145cgt tgc cag cag gtt cgt ggc gtt aat gcc cgc cct gtt ctg gtt ggt 595Arg Cys Gln Gln Val Arg Gly Val Asn Ala Arg Pro Val Leu Val Gly150 155 160 165cca ctg act ttc ctt tcc ctt gct cgc acc act gat ggt tcc aat cct 643Pro Leu Thr Phe Leu Ser Leu Ala Arg Thr Thr Asp Gly Ser Asn Pro

170 175 180ttg gat cac ctg cct gca ctg ttt gag gtc tac gag cgc ctc atc aag 691Leu Asp His Leu Pro Ala Leu Phe Glu Val Tyr Glu Arg Leu Ile Lys

185 190 195tct ttc gat act gag tgg gtt cag atc gat gag cct gcg ttg gtc acc 739Ser Phe Asp Thr Glu Trp Val Gln Ile Asp Glu Pro Ala Leu Val Thr

200 205 210gat gtt gct cct gag gtt ttg gag cag gtc cgc gct ggt tac acc act 787Asp Val Ala Pro Glu Val Leu Glu Gln Val Arg Ala Gly Tyr Thr Thr

215 220 225ttg gct aag cgc gat ggc gtg ttt gtc aat act tac ttc ggc tct ggc 835Leu Ala Lys Arg Asp Gly Val Phe Val Asn Thr Tyr Phe Gly Ser Gly230 235 240 245gat cag gcg ctg aac act ctt gcg ggc atc ggc ctt ggc gcg att ggc 883Asp Gln Ala Leu Asn Thr Leu Ala Gly Ile Gly Leu Gly Ala Ile Gly

250 255 260gtt gac ttg gtc acc cat ggc gtc act gag ctt gct gcg tgg aag ggt 931Val Asp Leu Val Thr His Gly Val Thr Glu Leu Ala Ala Trp Lys Gly

265 270 275gag gag ctg ctg gtt gcg ggc atc gtt gat ggt cgt aac att tgg cgc 979Glu Glu Leu Leu Val Ala Gly Ile Val Asp Gly Arg Asn Ile Trp Arg

280 285 290acc gac ctg tgt gct gct ctt gct tcc ctg aag cgc ctg gca gct cgc 1027Thr Asp Leu Cys Ala Ala Leu Ala Ser Leu Lys Arg Leu Ala Ala Arg

295 300 305ggc cca atc gca gtg tct acc tct tgt tca ctg ctg cac gtt cct tac 1075Gly Pro Ile Ala Val Ser Thr Ser Cys Ser Leu Leu His Val Pro Tyr310 315 320 325acc ctc gag gct gag aac att gag cct gag gtc cgc gac tgg ctt gcc 1123Thr Leu Glu Ala Glu Asn Ile Glu Pro Glu Val Arg Asp Trp Leu Ala

330 335 340ttc ggc tcg gag aag atc acc gag gtc aag ctg ctt gcc gac gcc cta 1171Phe Gly Ser Glu Lys Ile Thr Glu Val Lys Leu Leu Ala Asp Ala Leu

345 350 355gcc ggc aac atc gac gcg gct gcg ttc gat gcg gcg tcc gca gca att 1219Ala Gly Asn Ile Asp Ala Ala Ala Phe Asp Ala Ala Ser Ala Ala Ile

360 365 370gct tct cga cgc acc tcc cca cgc acc gca cca atc acg cag gaa ctc 1267Ala Ser Arg Arg Thr Ser Pro Arg Thr Ala Pro Ile Thr Gln Glu Leu

375 380 385cct ggc cgt agc cgt gga tcc ttc gac act cgt gtt acg ctg cag gag 1315Pro Gly Arg Ser Arg Gly Ser Phe Asp Thr Arg Val Thr Leu Gln Glu390 395 400 405aag tca ctg gag ctt cca gct ctg cca acc acc acc att ggt tct ttc 1363Lys Ser Leu Glu Leu Pro Ala Leu Pro Thr Thr Thr Ile Gly Ser Phe

410 415 420cca cag acc cca tcc att cgt tct gct cgc gct cgt ctg cgc aag gaa 1411Pro Gln Thr Pro Ser Ile Arg Ser Ala Arg Ala Arg Leu Arg Lys Glu

425 430 435tcc atc act ttg gag cag tac gaa gag gca atg cgc gaa gaa atc gat 1459Ser Ile Thr Leu Glu Gln Tyr Glu Glu Ala Met Arg Glu Glu Ile Asp

440 445 450ctg gtc atc gcc aag cag gaa gaa ctt ggt ctt gat gtg ttg gtt cac 1507Leu Val Ile Ala Lys Gln Glu Glu Leu Gly Leu Asp Val Leu Val His

455 460 465ggt gag cca gag cgc aac gac atg gtt cag tac ttc tct gaa ctt ctc 1555Gly Glu Pro Glu Arg Asn Asp Met Val Gln Tyr Phe Ser Glu Leu Leu470 475 480 485gac ggt ttc ctc tca acc gcc aac ggc tgg gtc caa agc tac ggc tcc 1603Asp Gly Phe Leu Ser Thr Ala Asn Gly Trp Val Gln Ser Tyr Gly Ser

490 495 500cgc tgt gtt cgt cct cca gtg ttg ttc gga aac gtt tcc cgc cca gcg 1651Arg Cys Val Arg Pro Pro Val Leu Phe Gly Asn Val Ser Arg Pro Ala

505 510 515cca atg act gtc aag tgg ttc cag tac gca cag agc ctg acc cag aag 1699Pro Met Thr Val Lys Trp Phe Gln Tyr Ala Gln Ser Leu Thr Gln Lys

520 525 530cat gtc aag gga atg ctc acc ggt cca gtc acc atc ctt gca tgg tcc 1747His Val Lys Gly Met Leu Thr Gly Pro Val Thr Ile Leu Ala Trp Ser

535 540 545ttc gtt cgc gat gat cag ccg ctg gct acc act gct gac cag gtt gca 1795Phe Val Arg Asp Asp Gln Pro Leu Ala Thr Thr Ala Asp Gln Val Ala550 555 560 565ctg gca ctg cgc gat gaa att aac gat ctc atc gag gct ggc gcg aag 1843Leu Ala Leu Arg Asp Glu Ile Asn Asp Leu Ile Glu Ala Gly Ala Lys

570 575 580atc atc cag gtg gat gag cct gcg att cgt gaa ctg ttg ccc gct acg 1891Ile Ile Gln Val Asp Glu Pro Ala Ile Arg Glu Leu Leu Pro Ala Thr

585 590 595aga cgt cga taagcctgcc tacctgcagt ggt 1923Arg Arg Arg

600<210>758<211>600<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>758Met Thr Ser Asn Phe Ser Ser Thr Val Ala Gly Leu Pro Arg Ile Gly 151015 Ala Lys Arg Glu Leu Lys Phe Ala Leu Glu Gly Tyr Trp Asn Gly Ser

20 25 30Ile Glu Gly Arg Glu Leu Ala Gln Thr Ala Arg Gln Leu Val Asn Thr

35 40 45Ala Ser Asp Ser Leu Ser Gly Leu Asp Ser Val Pro Phe Ala Gly Arg

50 55 60Ser Tyr Tyr Asp Ala Met Leu Asp Thr Ala Ala Ile Leu Gly Val Leu 65 70 75 80Pro Glu Arg Phe Asp Asp Ile Ala Asp His Glu Asn Asp Gly Leu Pro

85 90 95Leu Trp Ile Asp Arg Tyr Phe Gly Ala Ala Arg Gly Thr Glu Thr Leu

100 105 110Pro Ala Gln Ala Met Thr Lys Trp Phe Asp Thr Asn Tyr His Tyr Leu

115 120 125Val Pro Glu Leu Ser Ala Asp Thr Arg Phe Val Leu Asp Ala Ser Ala

130 135 140Leu Ile Glu Asp Leu Arg Cys Gln Gln Val Arg Gly Val Asn Ala Arg145 150 155 160Pro Val Leu Val Gly Pro Leu Thr Phe Leu Ser Leu Ala Arg Thr Thr

165 170 175Asp Gly Ser Asn Pro Leu Asp His Leu Pro Ala Leu Phe Glu Val Tyr

180 185 190Glu Arg Leu Ile Lys Ser Phe Asp Thr Glu Trp Val Gln Ile Asp Glu

195 200 205Pro Ala Leu Val Thr Asp Val Ala Pro Glu Val Leu Glu Gln Val Arg

210 215 220Ala Gly Tyr Thr Thr Leu Ala Lys Arg Asp Gly Val Phe Val Asn Thr225 230 235 240Tyr Phe Gly Ser Gly Asp Gln Ala Leu Asn Thr Leu Ala Gly Ile Gly

245 250 255Leu Gly Ala Ile Gly Val Asp Leu Val Thr His Gly Val Thr Glu Leu

260 265 270Ala Ala Trp Lys Gly Glu Glu Leu Leu Val Ala Gly Ile Val Asp Gly

275 280 285Arg Asn Ile Trp Arg Thr Asp Leu Cys Ala Ala Leu Ala Ser Leu Lys

290 295 300Arg Leu Ala Ala Arg Gly Pro Ile Ala Val Ser Thr Ser Cys Ser Leu305 310 315 320Leu His Val Pro Tyr Thr Leu Glu Ala Glu Asn Ile Glu Pro Glu Val

325 330 335Arg Asp Trp Leu Ala Phe Gly Ser Glu Lys Ile Thr Glu Val Lys Leu

340 345 350Leu Ala Asp Ala Leu Ala Gly Asn Ile Asp Ala Ala Ala Phe Asp Ala

355 360 365Ala Ser Ala Ala Ile Ala Ser Arg Arg Thr Ser Pro Arg Thr Ala Pro

370 375 380Ile Thr Gln Glu Leu Pro Gly Arg Ser Arg Gly Ser Phe Asp Thr Arg385 390 395 400Val Thr Leu Gln Glu Lys Ser Leu Glu Leu Pro Ala Leu Pro Thr Thr

405 410 415Thr Ile Gly Ser Phe Pro Gln Thr Pro Ser Ile Arg Ser Ala Arg Ala

420 425 430Arg Leu Arg Lys Glu Ser Ile Thr Leu Glu Gln Tyr Glu Glu Ala Met

435 440 445Arg Glu Glu Ile Asp Leu Val Ile Ala Lys Gln Glu Glu Leu Gly Leu

450 455 460Asp Val Leu Val His Gly Glu Pro Glu Arg Asn Asp Met Val Gln Tyr465 470 475 480Phe Ser Glu Leu Leu Asp Gly Phe Leu Ser Thr Ala Asn Gly Trp Val

485 490 495Gln Ser Tyr Gly Ser Arg Cys Val Arg Pro Pro Val Leu Phe Gly Asn

500 505 510Val Ser Arg Pro Ala Pro Met Thr Val Lys Trp Phe Gln Tyr Ala Gln

515 520 525Ser Leu Thr Gln Lys His Val Lys Gly Met Leu Thr Gly Pro Val Thr

530 535 540IleLeu Ala Trp Ser Phe Val Arg Asp Asp Gln Pro Leu Ala Thr Thr545 550 555 560Ala Asp Gln Val Ala Leu Ala Leu Arg Asp Glu Ile Asn Asp Leu Ile

565 570 575Glu Ala Gly Ala Lys Ile Ile Gln Val Asp Glu Pro Ala Ile Arg Glu

580 585 590Leu Leu Pro Ala Thr Arg Arg Arg

595600<210>759<211>603<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (580)<223>FRXA02086<400>759gatgatcagc cgctggctac cactgctgac caggttgcac tggcactgcg cgatgaaatt 60aacgatctca tcgaggctgg cgcgaagatc atccaggtgg atg agc ctg cga ttc 115

Met Ser Leu Arg Phe

1 5gtg aac tgt tgc ccg cta cga gac gtc gat aag cct gcc tac ctg cag 163Val Asn Cys Cys Pro Leu Arg Asp Val Asp Lys Pro Ala Tyr Leu Gln

10 15 20tgg tcc gtg gac tcc ttc cgc ctg gcg act gcc ggc gca ccc gac gac 211Trp Ser Val Asp Ser Phe Arg Leu Ala Thr Ala Gly Ala Pro Asp Asp

25 30 35gtc caa atc cac acc cac atg tgc tac tcc gag ttc aac gaa gtg atc 259Val Gln Ile His Thr His Met Cys Tyr Ser Glu Phe Asn Glu Val Ile

40 45 50tcc tcg gtc atc gcg ttg gat gcc gat gtc acc acc atc gaa gca gca 307Ser Ser Val Ile Ala Leu Asp Ala Asp Val Thr Thr Ile Glu Ala Ala

55 60 65cgt tcc gac atg cag gtc ctc gct gct ctg aaa tct tcc ggc ttc gag 355Arg Ser Asp Met Gln Val Leu Ala Ala Leu Lys Ser Ser Gly Phe Glu 70 75 80 85ctc ggc gtc gga cct ggt gtg tgg gat atc cac tcc ccg cgc gtt cct 403Leu Gly Val Gly Pro Gly Val Trp Asp Ile His Ser Pro Arg Val Pro

90 95 100tcc gcg cag aaa gtg gac ggt ctc ctc gag gct gca ctg cag tcc gtg 451Ser Ala Gln Lys Val Asp Gly Leu Leu Glu Ala Ala Leu Gln Ser Val

105 110 115gat cct cgc cag ctg tgg gtc aac cca gac tgt ggt ctg aag acc cgt 499Asp Pro Arg Gln Leu Trp Val Asn Pro Asp Cys Gly Leu Lys Thr Arg

120 125 130gga tgg cca gaa gtg gaa gct tcc cta aag gtt ctc gtt gag tcc gct 547Gly Trp Pro Glu Val Glu Ala Ser Leu Lys Val Leu Val Glu Ser Ala

135140145 aag cag gct cgt gag aaa atc gga gca act atc taaattgggt taccgctagg 600Lys Gln Ala Arg Glu Lys Ile Gly Ala Thr Ile 150155160 aac 603<210>760<211>160<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>760Met Ser Leu Arg Phe Val Asn Cys Cys Pro Leu Arg Asp Val Asp Lys 151015 Pro Ala Tyr Leu Gln Trp Ser Val Asp Ser Phe Arg Leu Ala Thr Ala

20 25 30Gly Ala Pro Asp Asp Val Gln Ile His Thr His Met Cys Tyr Ser Glu

35 40 45Phe Asn Glu Val Ile Ser Ser Val Ile Ala Leu Asp Ala Asp Val Thr

50 55 60Thr Ile Glu Ala Ala Arg Ser Asp Met Gln Val Leu Ala Ala Leu Lys 65 70 75 80Ser Ser Gly Phe Glu Leu Gly Val Gly Pro Gly Val Trp Asp Ile His

85 90 95Ser Pro Arg Val Pro Ser Ala Gln Lys Val Asp Gly Leu Leu Glu Ala

100 105 110Ala Leu Gln Ser Val Asp Pro Arg Gln Leu Trp Val Asn Pro Asp Cys

115 120 125Gly Leu Lys Thr Arg Gly Trp Pro Glu Val Glu Ala Ser Leu Lys Val

130135140 Leu Val Glu Ser Ala Lys Gln Ala Arg Glu Lys Ile Gly Ala Thr Ile 145150155160<210>761<211>1326<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1303)<223>RXN02648<400>761atgaataaaa ttccgggtgc agtgaccgta ggtgaggtaa acgcggttag agtcgaatga 60gagtttgata ctttctttcg acttttagat tggattttca atg agc cag aac cgc 115

Met Ser Gln Asn Arg

1 5atc agg acc act cac gtt ggt tcc ttg ccc cgt acc cca gag cta ctt 163Ile Arg Thr Thr His Val Gly Ser Leu Pro Arg Thr Pro Glu Leu Leu

10 15 20gat gca aac atc aag cgt tct aac ggt gag att ggg gag gag gaa ttc 211Asp Ala Asn Ile Lys Arg Ser Asn Gly Glu Ile Gly Glu Glu Glu Phe

25 30 35ttc cag att ctg cag tct tct gta gat gac gtg atc aag cgc cag gtt 259Phe Gln Ile Leu Gln Ser Ser Val Asp Asp Val Ile Lys Arg Gln Val

40 45 50gac ctg ggt atc gac atc ctt aac gag ggc gaa tac ggc cac gtc acc 307Asp Leu Gly Ile Asp Ile Leu Asn Glu Gly Glu Tyr Gly His Val Thr

55 60 65tcc ggt gca gtt gac ttc ggt gca tgg tgg aac tac tcc ttc acc cgc 355Ser Gly Ala Val Asp Phe Gly Ala Trp Trp Asn Tyr Ser Phe Thr Arg 7075 80 85ctg ggc gga ctg acc atg acc gat acc gac cgt tgg gca agc cag gaa 403Leu Gly Gly Leu Thr Met Thr Asp Thr Asp Arg Trp Ala Ser Gln Glu

90 95 100gca gtg cgt tcc acc cct ggc aac atc gag ctg acc agc ttc tct gat 451Ala Val Arg Ser Thr Pro Gly Asn Ile Glu Leu Thr Ser Phe Ser Asp

105 110 115cgt cgc gac cgc gca ttg ttc agc gaa gca tac gag gat cca gta tct 499Arg Arg Asp Arg Ala Leu Phe Ser Glu Ala Tyr Glu Asp Pro Val Ser

120 125 130ggc atc ttc acc ggt cgc gct tct gtg ggc aac cca gag ttc acc gga 547Gly Ile Phe Thr Gly Arg Ala Ser Val Gly Asn Pro Glu Phe Thr Gly

135 140 145cct att acc tac att ggc cag gaa gaa act cag acg gat gtt gat ctg 595Pro Ile Thr Tyr Ile Gly Gln Glu Glu Thr Gln Thr Asp Val Asp Leu150 155 160 165ctg aag aag ggc atg aac gca gcg gga gct acc gac ggc ttc gtt gca 643Leu Lys Lys Gly Met Asn Ala Ala Gly Ala Thr Asp Gly Phe Val Ala

170 175 180gca cta tcc cca gga tct gca gct cga ttg acc aac aag ttc tac gac 691Ala Leu Ser Pro Gly Ser Ala Ala Arg Leu Thr Asn Lys Phe Tyr Asp

185 190 195act gat gaa gaa gtc gtc gca gca tgt gct gat gcg ctt tcc cag gaa 739Thr Asp Glu Glu Val Val Ala Ala Cys Ala Asp Ala Leu Ser Gln Glu

200 205 210tac aag atc atc acc gat gca ggt ctg acc gtt cag ctc gac gca ccg 787Tyr Lys Ile Ile Thr Asp Ala Gly Leu Thr Val Gln Leu Asp Ala Pro

215 220 225gac ttg gca gaa gca tgg gat cag atc aac cca gag cca agc gtg aag 835Asp Leu Ala Glu Ala Trp Asp Gln Ile Asn Pro Glu Pro Ser Val Lys230 235 240 245gat tac ttg gac tgg atc ggt aca cgc atc gat gcc atc aac agt gca 883Asp Tyr Leu Asp Trp Ile Gly Thr Arg Ile Asp Ala Ile Asn Ser Ala

250 255 260gtg aag ggc ctt cca aag gaa cag acc cgc ctg cac atc tgc tgg ggc 931Val Lys Gly Leu Pro Lys Glu Gln Thr Arg Leu His Ile Cys Trp Gly

265 270 275tct tgg cac gga cca cac gtc act gac atc cca ttc ggt gac atc att 979Ser Trp His Gly Pro His Val Thr Asp Ile Pro Phe Gly Asp Ile Ile

280 285 290ggt gag atc ctg cgc gca gag gtc ggt ggc ttc tcc ttc gaa ggc gca 1027Gly Glu Ile Leu Arg Ala Glu Val Gly Gly Phe Ser Phe Glu Gly Ala

295 300 305tct cct cgt cac gca cac gag tgg cgt gta tgg gaa gaa aac aag ctt 1075Ser Pro Arg His Ala His Glu Trp Arg Val Trp Glu Glu Asn Lys Leu310 315 320 325cct gaa ggc tct gtt atc tac cct ggt gtt gtg tct cac tcc atc aac 1123Pro Glu Gly Ser Val Ile Tyr Pro Gly Val Val Ser His Ser Ile Asn

330 335 340gct gtg gag cac cca cgc ctg gtt gct gat cgt atc gtt cag ttc gcc 1171Ala Val Glu His Pro Arg Leu Val Ala Asp Arg Ile Val Gln Phe Ala

345 350 355aag ctt gtt ggc cct gag aac gtc att gcg tcc act gac tgt ggt ctg 1219Lys Leu Val Gly Pro Glu Asn Val Ile Ala Ser Thr Asp Cys Gly Leu

360 365 370ggc gga cgt ctg cat tcc cag atc gca tgg gca aag ctg gag tcc cta 1267Gly Gly Arg Leu His Ser Gln Ile Ala Trp Ala Lys Leu Glu Ser Leu

375380385 gta gag ggc gct cgc att gca tca aag gaa ctg ttc taagctagac 1313Val Glu Gly Ala Arg Ile Ala Ser Lys Glu Leu Phe 390395400 aacgagggttt gct 1326<210>762<211>401<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>762Met Ser Gln Asn Arg Ile Arg Thr Thr His Val Gly Ser Leu Pro Arg 151015 Thr Pro Glu Leu Leu Asp Ala Asn Ile Lys Arg Ser Asn Gly Glu Ile

20 25 30Gly Glu Glu Glu Phe Phe Gln Ile Leu Gln Ser Ser Val Asp Asp Val

35 40 45Ile Lys Arg Gln Val Asp Leu Gly Ile Asp Ile Leu Asn Glu Gly Glu

50 55 60Tyr Gly His Val Thr Ser Gly Ala Val Asp Phe Gly Ala Trp Trp Asn 65 70 75 80Tyr Ser Phe Thr Arg Leu Gly Gly Leu Thr Met Thr Asp Thr Asp Arg

85 90 95Trp Ala Ser Gln Glu Ala Val Arg Ser Thr Pro Gly Asn Ile Glu Leu

100 105 110Thr Ser Phe Ser Asp Arg Arg Asp Arg Ala Leu Phe Ser Glu Ala Tyr

115 120 125Glu Asp Pro Val Ser Gly Ile Phe Thr Gly Arg Ala Ser Val Gly Asn

130 135 140Pro Glu Phe Thr Gly Pro Ile Thr Tyr Ile Gly Gln Glu Glu Thr Gln145 150 155 160Thr Asp Val Asp Leu Leu Lys Lys Gly Met Asn Ala Ala Gly Ala Thr

165 170 175Asp Gly Phe Val Ala Ala Leu Ser Pro Gly Ser Ala Ala Arg Leu Thr

180 185 190Asn Lys Phe Tyr Asp Thr Asp Glu GluVal Val Ala Ala Cys Ala Asp

195 200 205Ala Leu Ser Gln Glu Tyr Lys Ile Ile Thr Asp Ala Gly Leu Thr Val

210 215 220Gln Leu Asp Ala Pro Asp Leu Ala Glu Ala Trp Asp Gln Ile Asn Pro225 230 235 240Glu Pro Ser Val Lys Asp Tyr Leu Asp Trp Ile Gly Thr Arg Ile Asp

245 250 255Ala Ile Asn Ser Ala Val Lys Gly Leu Pro Lys Glu Gln Thr Arg Leu

260 265 270His Ile Cys Trp Gly Ser Trp His Gly Pro His Val Thr Asp Ile Pro

275 280 285Phe Gly Asp Ile Ile Gly Glu Ile Leu Arg Ala Glu Val Gly Gly Phe

290 295 300Ser Phe Glu Gly Ala Ser Pro Arg His Ala His Glu Trp Arg Val Trp305 310 315 320Glu Glu Asn Lys Leu Pro Glu Gly Ser Val Ile Tyr Pro Gly Val Val

325 330 335Ser His Ser Ile Asn Ala Val Glu His Pro Arg Leu Val Ala Asp Arg

340 345 350Ile Val Gln Phe Ala Lys Leu Val Gly Pro Glu Asn Val Ile Ala Ser

355 360 365Thr Asp Cys Gly Leu Gly Gly Arg Leu His Ser Gln Ile Ala Trp Ala

370375380 Lys Leu Glu Ser Leu Val Glu Gly Ala Arg Ile Ala Ser Lys Glu Leu 385390395400 Phe<210>763<211>548<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (525)<223>FRXA02648<400>763gac gca ccg gac ttg gca gaa gca tgg gat cag atc aac cca gag cca 48Asp Ala Pro Asp Leu Ala Glu Ala Trp Asp Gln Ile Asn Pro Glu Pro 151015 agc gtg aag gat tac ttg gac tgg atc ggt aca cgc atc gat gcc atc 96Ser Val Lys Asp Tyr Leu Asp Trp Ile Gly Thr Arg Ile Asp Ala Ile

20 25 30aac agt gca gtg aag ggc ctt cca aag gaa cag acc cgc ctg cac atc 144Asn Ser Ala Val Lys Gly Leu Pro Lys Glu Gln Thr Arg Leu His Ile

35 40 45tgc tgg ggc tct tgg cac gga cca cac gtc act gac atc cca ttc ggt 192Cys Trp Gly Ser Trp His Gly Pro His Val Thr Asp Ile Pro Phe Gly

50 55 60gac atc att ggt gag atc ctg cgc gca gag gtc ggt ggc ttc tcc ttc 240Asp Ile Ile Gly Glu Ile Leu Arg Ala Glu Val Gly Gly Phe Ser Phe 65 70 75 80gaa ggc gca tct cct cgt cac gca cac gag tgg cgt gta tgg gaa gaa 288Glu Gly Ala Ser Pro Arg His Ala His Glu Trp Arg Val Trp Glu Glu

85 90 95aac aag ctt cct gaa ggc tct gtt atc tac cct ggt gtt gtg tct cac 336Asn Lys Leu Pro Glu Gly Ser Val Ile Tyr Pro Gly Val Val Ser His

100 105 110tcc atc aac gct gtg gag cac cca cgc ctg gtt gct gat cgt atc gtt 384Ser Ile Asn Ala Val Glu His Pro Arg Leu Val Ala Asp Arg Ile Val

115 120 125cag ttc gcc aag ctt gtt ggc cct gag aac gtc att gcg tcc act gac 432Gln Phe Ala Lys Leu Val Gly Pro Glu Asn Val Ile Ala Ser Thr Asp

130 135 140tgt ggt ctg ggc gga cgt ctg cat tcc cag atc gca tgg gca aag ctg 480Cys Gly Leu Gly Gly Arg Leu His Ser Gln Ile Ala Trp Ala Lys Leu145 150 155 160gag tcc cta gta gag ggc gct cgc att gca tca aag gaa ctg ttc 525Glu Ser Leu Val Glu Gly Ala Arg Ile Ala Ser Lys Glu Leu Phe

165170175 taagctagac aacgagggtt gct 548<210>764<211>175<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>764Asp Ala Pro Asp Leu Ala Glu Ala Trp Asp Gln Ile Asn Pro Glu Pro 151015 Ser Val Lys Asp Tyr Leu Asp Trp Ile Gly Thr Arg Ile Asp Ala Ile

20 25 30Asn Ser Ala Val Lys Gly Leu Pro Lys Glu Gln Thr Arg Leu His Ile

35 40 45Cys Trp Gly Ser Trp His Gly Pro His Val Thr Asp Ile Pro Phe Gly

50 55 60Asp Ile Ile Gly Glu Ile Leu Arg Ala Glu Val Gly Gly Phe Ser Phe 65 70 75 80Glu Gly Ala Ser Pro Arg His Ala His Glu Trp Arg Val Trp Glu Glu

85 90 95Asn Lys Leu Pro Glu Gly Ser Val Ile Tyr Pro Gly Val Val Ser His

100 105 110Ser Ile Asn Ala Val Glu His Pro Arg Leu Val Ala Asp Arg Ile Val

115 120 125Gln Phe Ala Lys Leu Val Gly Pro Glu Asn Val Ile Ala Ser Thr Asp

130 135 140Cys Gly Leu Gly Gly Arg Leu His Ser Gln Ile Ala Trp Ala Lys Leu145 150 155 160Glu Ser Leu Val Glu Gly Ala Arg Ile Ala Ser Lys Glu Leu Phe

165170175<210>765<211>784<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (784)<223>FRXA02658<400>765atgaataaaa ttccgggtgc agtgaccgta ggtgaggtaa acgcggttag agtcgaatga 60gagtttgata ctttctttcg acttttagat tggattttca atg agc cag aac cgc 115

Met Ser Gln Asn Arg

1 5atc agg acc act cac gtt ggt tcc ttg ccc cgt acc cca gag cta ctt 163Ile Arg Thr Thr His Val Gly Ser Leu Pro Arg Thr Pro Glu Leu Leu

10 15 20gat gca aac atc aag cgt tct aac ggt gag att ggg gag gag gaa ttc 211Asp Ala Asn Ile Lys Arg Ser Asn Gly Glu Ile Gly Glu Glu Glu Phe

25 30 35ttc cag att ctg cag tct tct gta gat gac gtg atc aag cgc cag gtt 259Phe Gln Ile Leu Gln Ser Ser Val Asp Asp Val Ile Lys Arg Gln Val

40 45 50gac ctg ggt atc gac atc ctt aac gag ggc gaa tac ggc cac gtc acc 307Asp Leu Gly Ile Asp Ile Leu Asn Glu Gly Glu Tyr Gly His Val Thr

55 60 65tcc ggt gca gtt gac ttc ggt gca tgg tgg aac tac tcc ttc acc cgc 355Ser Gly Ala Val Asp Phe Gly Ala Trp Trp Asn Tyr Ser Phe Thr Arg 70 75 80 85ctg ggc gga ctg acc atg acc gat acc gac cgt tgg gca agc cag gaa 403Leu Gly Gly Leu Thr Met Thr Asp Thr Asp Arg Trp Ala Ser Gln Glu

90 95 100gca gtg cgt tcc acc cct ggc aac atc gag ctg acc agc ttc tct gat 451Ala Val Arg Ser Thr Pro Gly Asn Ile Glu Leu Thr Ser Phe Ser Asp

105 110 115cgt cgc gac cgc gca ttg ttc agc gaa gca tac gag gat cca gta tct 499Arg Arg Asp Arg Ala Leu Phe Ser Glu Ala Tyr Glu Asp Pro Val Ser

120 125130ggc atc ttc acc ggt cgc gct tct gtg ggc aac cca gag ttc acc gga 547Gly Ile Phe Thr Gly Arg Ala Ser Val Gly Asn Pro Glu Phe Thr Gly

135 140 145cct att acc tac att ggc cag gaa gaa act cag acg gat gtt gat ctg 595Pro Ile Thr Tyr Ile Gly Gln Glu Glu Thr Gln Thr Asp Val Asp Leu150 155 160 165ctg aag aag ggc atg aac gca gcg gga gct acc gac ggc ttc gtt gca 643Leu Lys Lys Gly Met Asn Ala Ala Gly Ala Thr Asp Gly Phe Val Ala

170 175 180gca cta tcc cca gga tct gca gct cga ttg acc aac aag ttc tac gac 691Ala Leu Ser Pro Gly Ser Ala Ala Arg Leu Thr Asn Lys Phe Tyr Asp

185 190 195act gat gaa gaa gtc gtc gca gca tgt gct gat gcg ctt tcc cag gaa 739Thr Asp Glu Glu Val Val Ala Ala Cys Ala Asp Ala Leu Ser Gln Glu

200 205 210tac aag atc atc acc gat gca ggt ctg acc gtt cag ctc gac gca 784Tyr Lys Ile Ile Thr Asp Ala Gly Leu Thr Val Gln Leu Asp Ala

215220225<210>766<211>228<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>766Met Ser Gln Asn Arg Ile Arg Thr Thr His Val Gly Ser Leu Pro Arg 151015 Thr Pro Glu Leu Leu Asp Ala Asn Ile Lys Arg Ser Asn Gly Glu Ile

20 25 30Gly Glu Glu Glu Phe Phe Gln Ile Leu Gln Ser Ser Val Asp Asp Val

35 40 45Ile Lys Arg Gln Val Asp Leu Gly Ile Asp Ile Leu Asn Glu Gly Glu

50 55 60Tyr Gly His Val Thr Ser Gly Ala Val Asp Phe Gly Ala Trp Trp Asn 65 70 7580Tyr Ser Phe Thr Arg Leu Gly Gly Leu Thr Met Thr Asp Thr Asp Arg

85 90 95Trp Ala Ser Gln Glu Ala Val Arg Ser Thr Pro Gly Asn Ile Glu Leu

100 105 110Thr Ser Phe Ser Asp Arg Arg Asp Arg Ala Leu Phe Ser Glu Ala Tyr

115 120 125Glu Asp Pro Val Ser Gly Ile Phe Thr Gly Arg Ala Ser Val Gly Asn

130 135 140Pro Glu Phe Thr Gly Pro Ile Thr Tyr Ile Gly Gln Glu Glu Thr Gln145 150 155 160Thr Asp Val Asp Leu Leu Lys Lys Gly Met Asn Ala Ala Gly Ala Thr

165 170 175Asp Gly Phe Val Ala Ala Leu Ser Pro Gly Ser Ala Ala Arg Leu Thr

180 185 190Asn Lys Phe Tyr Asp Thr Asp Glu Glu Val Val Ala Ala Cys Ala Asp

195 200 205Ala Leu Ser Gln Glu Tyr Lys Ile Ile Thr Asp Ala Gly Leu Thr Val

210215220 Gln Leu Asp Ala225<210>767<211>513<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<490>RXA01516<400>767tctgcacata tgggagcatg gggtgtgcgc gtgcacgatg tcccagtatc aagggacgct 60gttgatgttg ccgcattgtg gcgaagtgga ggaactcacc atg gct gat cgt att 115

Met Ala Asp Arg Ile

1 5gaa ctt aaa ggc ctt gaa tgc ttc gga cac cac ggt gtg ttc gac ttt 163Glu Leu Lys Gly Leu Glu Cys Phe Gly His His Gly Val Phe Asp Phe

10 15 20gaa aaa gag caa ggc cag ccc ttc att gtg gat gtc acc tgc tgg atg 211Glu Lys Glu Gln Gly Gln Pro Phe Ile Val Asp Val Thr Cys Trp Met

25 30 35gat ttc gat gcc gca ggt gcc agc gat gac ctt tcc gac acc gta gat 259Asp Phe Asp Ala Ala Gly Ala Ser Asp Asp Leu Ser Asp Thr Val Asp

40 45 50tac ggc gcg ttg gca ttg ttg gtt gct gaa atc gtg gaa ggc cca tcc 307Tyr Gly Ala Leu Ala Leu Leu Val Ala Glu Ile Val Glu Gly Pro Ser

55 60 65agg gat ttg atc gag acg gtg gcc acg gaa tct gcg gat gct gtg atg 355Arg Asp Leu Ile Glu Thr Val Ala Thr Glu Ser Ala Asp Ala Val Met 70 75 80 85gct aaa ttt gat gcg ctt cat gcg gtg gaa gta acc atc cat aag ccc 403Ala Lys Phe Asp Ala Leu His Ala Val Glu Val Thr Ile His Lys Pro

90 95 100aaa gca ccg atc cca cgt act ttt gct gac gtc gcg gtg gtt gcc cga 451Lys Ala Pro Ile Pro Arg Thr Phe Ala Asp Val Ala Val Val Ala Arg

105 110 115cgt tcc agg aaa tcc atg gct gct gga agg agc aac gcc taatgcatgc 500Arg Ser Arg Lys Ser Met Ala Ala Gly Arg Ser Asn Ala

120125130 agttttgtcc atc 513<210>768<211>130<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>768Met Ala Asp Arg Ile Glu Leu Lys Gly Leu Glu Cys Phe Gly His His 151015 Gly Val Phe Asp Phe Glu Lys Glu Gln Gly Gln Pro Phe Ile Val Asp

20 25 30Val Thr Cys Trp Met Asp Phe Asp Ala Ala Gly Ala Ser Asp Asp Leu

35 40 45Ser Asp Thr Val Asp Tyr Gly Ala Leu Ala Leu Leu Val Ala Glu Ile

50 55 60Val Glu Gly Pro Ser Arg Asp Leu Ile Glu Thr Val Ala Thr Glu Ser 65 70 75 80Ala Asp Ala Val Met Ala Lys Phe Asp Ala Leu His Ala Val Glu Val

85 90 95Thr Ile His Lys Pro Lys Ala Pro Ile Pro Arg Thr Phe Ala Asp Val

100 105 110Ala Val Val Ala Arg Arg Ser Arg Lys Ser Met Ala Ala Gly Arg Ser

115 120 125Asn Ala

130<210>769<211>975<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (952)<223>RXA01515<400>769taagcctggt gctgtgacca cgacgtctgc ggtgcgcggc ggttttaaga acaacgctgc 60ctcccgcgct gaggtgttct ccctgattcg ggggcactaa atg aac gta tcc tct 115

Met Asn Val Ser Ser

1 5ttg acc atc ccg gga cgc tgt ttg gtc atg gga att gtc aat gtc act 163Leu Thr Ile Pro Gly Arg Cys Leu Val Met Gly Ile Val Asn Val Thr

10 15 20gag gat tcc ttt tcg gac ggt ggc aag tac att gac gtt gat cag gcg 211Glu Asp Ser Phe Ser Asp Gly Gly Lys Tyr Ile Asp Val Asp Gln Ala

25 30 35atc gcg cat gcc aag gaa ttg gtg gct gct ggc gcc gac atg att gat 259Ile Ala His Ala Lys Glu Leu Val Ala Ala Gly Ala Asp Met Ile Asp

40 45 50gtc ggc ggc gag tcc acc cgg cct ggg gca gtg cgc gtc gac gcg tcc307Val Gly Gly Glu Ser Thr Arg Pro Gly Ala Val Arg Val Asp Ala Ser

55 60 65gtg gaa cgg gac cgg gtt gtg ccg gtc att aag gcg ctt cac gac gcc 355Val Glu Arg Asp Arg Val Val Pro Val Ile Lys Ala Leu His Asp Ala 70 75 80 85ggc atc cac act tcc gta gac acc atg cgg gcc tcc gtg gcg cag gct 403Gly Ile His Thr Ser Val Asp Thr Met Arg Ala Ser Val Ala Gln Ala

90 95 100gcc gcg ggc gct ggc gtc tcc atg atc aac gac gtc tct ggc ggt ttg 451Ala Ala Gly Ala Gly Val Ser Met Ile Asn Asp Val Ser Gly Gly Leu

105 110 115gct gat cct gag atg ttt tct gtc atg gcg gaa gcg caa att ccc gtg 499Ala Asp Pro Glu Met Phe Ser Val Met Ala Glu Ala Gln Ile Pro Val

120 125 130tgt ttg atg cac tgg cgc acc ctc caa ttc ggt gat gcc gca ggt cag 547Cys Leu Met His Trp Arg Thr Leu Gln Phe Gly Asp Ala Ala Gly Gln

135 140 145gca gat cac ggt gga gac gtt gta gcc gat gtg cac gca gtg ctt gat 595Ala Asp His Gly Gly Asp Val Val Ala Asp Val His Ala Val Leu Asp150 155 160 165gat ctt gtc gcc cgc gcc acc gct gct ggt gtg gcc gaa aac cag atc 643Asp Leu Val Ala Arg Ala Thr Ala Ala Gly Val Ala Glu Asn Gln Ile

170 175 180gtg ctt gat cca ggt ttg ggt ttt gcc aaa tea cgt gaa gac aac tgg 691Val Leu Asp Pro Gly Leu Gly Phe Ala Lys Ser Arg Glu Asp Asn Trp

185 190 195cgt ttg ctg caa gca ctg ccc gag ttt att tct gga cct ttc ccc atc 739Arg Leu Leu Gln Ala Leu Pro Glu Phe Ile Ser Gly Pro Phe Pro Ile

200 205 210ctg gtg gga gca tcc cgg aag cga ttc ctg gct ggc gtg cgc aaa gac 787Leu Val Gly Ala Ser Arg Lys Arg Phe Leu Ala Gly Val Arg Lys Asp

215 220 225cgt ggc cta gat gtc acc ccc att gat gcc gac cca gca acc gca gcg 835Arg Gly Leu Asp Val Thr Pro Ile Asp Ala Asp Pro Ala Thr Ala Ala230 235 240 245gtg acc gca gtg tct gca cat atg gga gca tgg ggt gtg cgc gtg cac 883Val Thr Ala Val Ser Ala His Met Gly Ala Trp Gly Val Arg Val His

250 255 260gat gtc cca gta tca agg gac gct gtt gat gtt gcc gca ttg tgg cga 931Asp Val Pro Val Ser Arg Asp Ala Val Asp Val Ala Ala Leu Trp Arg

265 270 275agt gga gga act cac cat ggc tgatcgtatt gaacttaaag gcc 975Ser Gly Gly Thr His His Gly

280<210>770<211>284<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>770Met Asn Val Ser Ser Leu Thr Ile Pro Gly Arg Cys Leu Val Met Gly 151015 Ile Val Asn Val Thr Glu Asp Ser Phe Ser Asp Gly Gly Lys Tyr Ile

20 25 30Asp Val Asp Gln Ala Ile Ala His Ala Lys Glu Leu Val Ala Ala Gly

35 40 45Ala Asp Met Ile Asp Val Gly Gly Glu Ser Thr Arg Pro Gly Ala Val

50 55 60Arg Val Asp Ala Ser Val Glu Arg Asp Arg Val Val Pro Val Ile Lys 65 70 75 80Ala Leu His Asp Ala Gly Ile His Thr Ser Val Asp Thr Met Arg Ala

85 90 95Ser Val Ala Gln Ala Ala Ala Gly Ala Gly Val Ser Met Ile Asn Asp

100 105 110Val Ser Gly Gly Leu Ala Asp Pro Glu Met Phe Ser Val Met Ala Glu

115 120 125Ala Gln Ile Pro Val Cys Leu Met His Trp Arg Thr Leu Gln Phe Gly

130 135 140Asp Ala Ala Gly Gln Ala Asp His Gly Gly Asp Val Val Ala Asp Val145 150 155 160His Ala Val Leu Asp Asp Leu Val Ala Arg Ala Thr Ala Ala Gly Val

165 170 175Ala Glu Asn Gln Ile Val Leu Asp Pro Gly Leu Gly Phe Ala Lys Ser

180 185 190Arg Glu Asp Asn Trp Arg Leu Leu Gln Ala Leu Pro Glu Phe Ile Ser

195 200 205Gly Pro Phe Pro Ile Leu Val Gly Ala Ser Arg Lys Arg Phe Leu Ala

210 215 220Gly Val Arg Lys Asp Arg Gly Leu Asp Val Thr Pro Ile Asp Ala Asp225 230 235 240Pro Ala Thr Ala Ala Val Thr Ala Val Ser Ala His Met Gly Ala Trp

245 250 255Gly Val Arg Val His Asp Val Pro Val Ser Arg Asp Ala Val Asp Val

260 265 270Ala Ala Leu Trp Arg Ser Gly Gly Thr His His Gly

275280<210>771<211>859<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (859)<223>RXA02024<400>771cactgatgac ctggatcagg ccgtcaaatt catcgtcgat gcacacgctg gattggacgt 60agcgcgtctc cacaattaag cagtggctac attaggtgtt atg agt tct ttg ccg 115

Met Ser Ser Leu Pro

1 5gtc atc atg gcc atc gtc aat cgc acc ccg gat tct ttc tat gac aag 163Val Ile Met Ala Ile Val Asn Arg Thr Pro Asp Ser Phe Tyr Asp Lys

10 15 20ggt gcg aca ttt gag gac acc gct gcg cta aac agg gca gcg gag gtc 211Gly Ala Thr Phe Glu Asp Thr Ala Ala Leu Asn Arg Ala Ala Glu Val

25 30 35att gaa caa ggc gcc ggc att gtc gat atc ggt ggg gtg aaa gcc ggc 259Ile Glu Gln Gly Ala Gly Ile Val Asp Ile Gly Gly Val Lys Ala Gly

40 45 50ccg ggg gat ttc gtg tcg gcg gag gaa gag atc gac cgc gtg gtg cca 307Pro Gly Asp Phe Val Ser Ala Glu Glu Glu Ile Asp Arg Val Val Pro

55 60 65atc atc gct gcg gtg cga gaa cgt ttt cct gac att gat att tct gtt 355Ile Ile Ala Ala Val Arg Glu Arg Phe Pro Asp Ile Asp Ile Ser Val 70 75 80 85gat acc tgg cgg gcg tcg gtg gct gat gtc gca gtg gcg cat gga gca 403Asp Thr Trp Arg Ala Ser Val Ala Asp Val Ala Val Ala His Gly Ala

90 95 100acg ctg atc aat gac act tgg gcc ggc cat gat cat gag ttg gtg cag 451Thr Leu Ile Asn Asp Thr Trp Ala Gly His Asp His Glu Leu Val Gln

105 110 115gta gca ggg cag cac aag gtg ggt tat gtc tgc tcg cac acc ggc ggg 499Val Ala Gly Gln His Lys Val Gly Tyr Val Cys Ser His Thr Gly Gly

120 125 130gtg att cca aga acg cga cca tat cgg gtg cat ttc gat gac atc gtg 547Val Ile Pro Arg Thr Arg Pro Tyr Arg Val His Phe Asp Asp Ile Val

135 140 145gcc gat gta att acg gag acc acc aaa ttg gca gag caa gct gtt cgt 595Ala Asp Val Ile Thr Glu Thr Thr Lys Leu Ala Glu Gln Ala Val Arg150 155 160 165gcc ggg gtg cca gag gaa cgg gtg ttt att gat ccc acc cat gat ttc 643Ala Gly Val Pro Glu Glu Arg Val Phe Ile Asp Pro Thr His Asp Phe

170 175 180ggg aaa aac acc ttc cac gga ctg gag ctt tta cga cgg atc gat gag 691Gly Lys Asn Thr Phe His Gly Leu Glu Leu Leu Arg Arg Ile Asp Glu

185 190 195gtg gtt gcc acg ggc tgg ccg gtg ctg atg gcc ttg agt aat aag gat 739Val Val Ala Thr Gly Trp Pro Val Leu Met Ala Leu Ser Asn Lys Asp

200 205 210ttc att ggg gaa act ttg gaa agg ggc gtc gat aag cgt gtt gct ggc 787Phe Ile Gly Glu Thr Leu Glu Arg Gly Val Asp Lys Arg Val Ala Gly

215 220 225acg ctt gct gcc act gcc tgg gcg gcg gcg cgc ggc gtt gcg gct ttt 835Thr Leu Ala Ala Thr Ala Trp Ala Ala Ala Arg Gly Val Ala Ala Phe230 235 240 245cgc gtg cat gaa gtt gcg gaa acc 859Arg Val His Glu Val Ala Glu Thr

250<210>772<211>253<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>772Met Ser Ser Leu Pro Val Ile Met Ala Ile Val Asn Arg Thr Pro Asp 151015 Ser Phe Tyr Asp Lys Gly Ala Thr Phe Glu Asp Thr Ala Ala Leu Asn

20 25 30Arg Ala Ala Glu Val Ile Glu Gln Gly Ala Gly Ile Val Asp Ile Gly

35 40 45Gly Val Lys Ala Gly Pro GlyAsp Phe Val Ser Ala Glu Glu Glu Ile

50 55 60Asp Arg Val Val Pro Ile Ile Ala Ala Val Arg Glu Arg Phe Pro Asp 65 70 75 80Ile Asp Ile Ser Val Asp Thr Trp Arg Ala Ser Val Ala Asp Val Ala

85 90 95Val Ala His Gly Ala Thr Leu Ile Asn Asp Thr Trp Ala Gly His Asp

100 105 110His Glu Leu Val Gln Val Ala Gly Gln His Lys Val Gly Tyr Val Cys

115 120 125Ser His Thr Gly Gly Val Ile Pro Arg Thr Arg Pro Tyr Arg Val His

130 135 140Phe Asp Asp Ile Val Ala Asp Val Ile Thr Glu Thr Thr Lys Leu Ala145 150 155 160Glu Gln Ala Val Arg Ala Gly Val Pro Glu Glu Arg Val Phe Ile Asp

165 170 175Pro Thr His Asp Phe Gly Lys Asn Thr Phe His Gly Leu Glu Leu Leu

180 185 190Arg Arg Ile Asp Glu Val Val Ala Thr Gly Trp Pro Val Leu Met Ala

195 200 205Leu Ser Asn Lys Asp Phe Ile Gly Glu Thr Leu Glu Arg Gly Val Asp

210 215 220Lys Arg Val Ala Gly Thr Leu Ala Ala Thr Ala Trp Ala Ala Ala Arg225 230 235 240Gly Val Ala Ala Phe Arg Val His Glu Val Ala Glu Thr

245250<210>773<211>684<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<661>RXA01719<400>773ccatatggtc ggtgcactgg ctggaagtgg cggtattgca ctggtgactt cgtcgattgc 60cgaggacggt ctggttgatg ttgtgctggg gagaatgtaa atg aat atc atc att 115

Met Asn Ile Ile Ile

1 5ctt gct ggt ggc gag ggt aaa cgc atg ggt ggg gtg gat aag gct gct 163Leu Ala Gly Gly Glu Gly Lys Arg Met Gly Gly Val Asp Lys Ala Ala

10 15 20gtg gcg gtg gat ggt cgc acg ctg ctg gat atc ctg ctt tca cag ctg 211Val Ala Val Asp Gly Arg Thr Leu Leu Asp Ile Leu Leu Ser Gln Leu

25 30 35gat cca gaa gat gac gtc gtg gtg gtt tcc ccc gcg atc atc gac gga 259Asp Pro Glu Asp Asp Val Val Val Val Ser Pro Ala Ile Ile Asp Gly

40 45 50atc acg act gtc tgc gag gaa cct ccg ctt ggc ggg ccg gtc gcg gga 307Ile Thr Thr Val Cys Glu Glu Pro Pro Leu Gly Gly Pro Val Ala Gly

55 60 65atc gag gca ggg ctg aat tct ttt gag cac gcc cat gaa ttc act gcg 355Ile Glu Ala Gly Leu Asn Ser Phe Glu His Ala His Glu Phe Thr Ala 70 75 80 85att ctt gcc gtg gac gcg cct tat tct gca gcg atg ctg ccc cta ctt 403Ile Leu Ala Val Asp Ala Pro Tyr Ser Ala Ala Met Leu Pro Leu Leu

90 95 100cag gca cag att ggc aaa gcc gat gtg gcc gta acc ctt gct gcc gat 451Gln Ala Gln Ile Gly Lys Ala Asp Val Ala Val Thr Leu Ala Ala Asp

105 110 115ggc tgg gta caa ccg ttg tgc gcg ctg tgg aga agt ggc agc cta gaa 499Gly Trp Val Gln Pro Leu Cys Ala Leu Trp Arg Ser Gly Ser Leu Glu

120 125130gcg gtg att cac agc ctg ggc gag act aga aat cga ccg gca aaa gcg 547Ala Val Ile His Ser Leu Gly Glu Thr Arg Asn Arg Pro Ala Lys Ala

135 140 145tta ctg aag caa gcg gga cac att gtg gaa gtg ggt ggc gat ggc act 595Leu Leu Lys Gln Ala Gly His Ile Val Glu Val Gly Gly Asp Gly Thr150 155 160 165gaa aaa gac tac gat acg gtg gct gaa ctg gag gta ttg ggc aac gta 643Glu Lys Asp Tyr Asp Thr Val Ala Glu Leu Glu Val Leu Gly Asn Val

170 175 180acg ctc cct aaa gcc cac tgatgagaaa cgtgagctct gct 684Thr Leu Pro Lys Ala His

185<210>774<211>187<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>774Met Asn Ile Ile Ile Leu Ala Gly Gly Glu Gly Lys Arg Met Gly Gly 151015 Val Asp Lys Ala Ala Val Ala Val Asp Gly Arg Thr Leu Leu Asp Ile

20 25 30Leu Leu Ser Gln Leu Asp Pro Glu Asp Asp Val Val Val Val Ser Pro

35 40 45Ala Ile Ile Asp Gly Ile Thr Thr Val Cys Glu Glu Pro Pro Leu Gly

50 55 60Gly Pro Val Ala Gly Ile Glu Ala Gly Leu Asn Ser Phe Glu His Ala 65 70 75 80His Glu Phe Thr Ala Ile Leu Ala Val Asp Ala Pro Tyr Ser Ala Ala

85 90 95Met Leu Pro Leu Leu Gln Ala Gln Ile Gly Lys Ala Asp Val Ala Val

100 105 110Thr Leu Ala Ala Asp Gly Trp Val Gln Pro Leu Cys Ala Leu Trp Arg

115 120 125Ser Gly Ser Leu Glu Ala ValIle His Ser Leu Gly Glu Thr Arg Asn

130 135 140Arg Pro Ala Lys Ala Leu Leu Lys Gln Ala Gly His Ile Val Glu Val145 150 155 160Gly Gly Asp Gly Thr Glu Lys Asp Tyr Asp Thr Val Ala Glu Leu Glu

165 170 175Val Leu Gly Asn Val Thr Leu Pro Lys Ala His

180185<210>775<211>1332<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1309)<223>RXA01720<400>775acacccgttt gagaatctca acctcttaaa acagcgcgaa ctattgattt ggcaactacc 60ctatatattt gagtgtttat tgtcgaaaaa ggggtttcaa gtg gca cag caa cgc 115

Val Ala Gln Gln Arg

1 5agc gtc gat gac tat ctt tcc att ttg ata gac agc gtc gca ccg ctt 163Ser Val Asp Asp Tyr Leu Ser Ile Leu Ile Asp Ser Val Ala Pro Leu

10 15 20ccg cca gta aaa acc cct atc ctc ggc gcg cat ccg tta agt cac ctt 211Pro Pro Val Lys Thr Pro Ile Leu Gly Ala His Pro Leu Ser His Leu

25 30 35gca gag gat gtt gtc gcg aca att cct atc ccg aaa ttt act aat tct 259Ala Glu Asp Val Val Ala Thr Ile Pro Ile Pro Lys Phe Thr Asn Ser

40 45 50gct gtt gat ggt tac gcc att ttg aaa gaa gac atc cat ggc agc ggg 307Ala Val Asp Gly Tyr Ala Ile Leu Lys Glu Asp Ile His Gly Ser Gly

55 60 65ccg tgg aca ttt ctt gtg ggc ggt gat act ccg gcg ggt tct gcg ccg 355Pro Trp Thr Phe Leu Val Gly Gly Asp Thr Pro Ala Gly Ser Ala Pro 70 75 80 85gcg agc att aat aat gga aaa gcc atc cgt gtg atg aca ggt gga ccc 403Ala Ser Ile Asn Asn Gly Lys Ala Ile Arg Val Met Thr Gly Gly Pro

90 95 100gtc cca tcc acc aac aag gac atg atc gtg gtt cca gtg gag ctc acc 451Val Pro Ser Thr Asn Lys Asp Met Ile Val Val Pro Val Glu Leu Thr

105 110 115aat gct ccg gtg gat cac tcg ctt cct aca gaa atc acg atc aat gag 499Asn Ala Pro Val Asp His Ser Leu Pro Thr Glu Ile Thr Ile Asn Glu

120 125 130cta cca ggt gag agg aat aat att cgc cat gct ggt gag cat ctt aaa 547Leu Pro Gly Glu Arg Asn Asn Ile Arg His Ala Gly Glu His Leu Lys

135 140 145gaa ggc gaa att gcg gtt gct gcg ggg acg gca ttt gat gcg ggt act 595Glu Gly Glu Ile Ala Val Ala Ala Gly Thr Ala Phe Asp Ala Gly Thr150 155 160 165gtg tcg acg gtg att tca gtt ggc cat gac act gta aaa gcc cat cct 643Val Ser Thr Val Ile Ser Val Gly His Asp Thr Val Lys Ala His Pro

170 175 180tgc cct cgg gtt gcg gtg atc act acc ggt gat gag cta aac cag gga 691Cys Pro Arg Val Ala Val Ile Thr Thr Gly Asp Glu Leu Asn Gln Gly

185 190 195aat ccc tgg ggt atc cct aat tcc aat ggg ccg atg ctg gtt gcg gag 739Asn Pro Trp Gly Ile Pro Asn Ser Asn Gly Pro Met Leu Val Ala Glu

200 205 210cta aaa cgc gtg ggg att aag gat ccg cag cat ttc cat tcc gat gat 787Leu Lys Arg Val Gly Ile Lys Asp Pro Gln His Phe His Ser Asp Asp

215 220 225tct gag act gca ttg agg gag acg ctc gat aag cct gca gag gtt gcg 835Ser Glu Thr Ala Leu Arg Glu Thr Leu Asp Lys Pro Ala Glu Val Ala230 235 240 245gat gtg atc atc act gtg ggt ggg atc tcg gcg ggc gcg ttc gat gtg 883Asp Val Ile Ile Thr Val Gly Gly Ile Ser Ala Gly Ala Phe Asp Val

250 255 260gtc aaa gcc gtg gga act aag act ggt ggt ttt gaa ttc ttc ccc att 931Val Lys Ala Val Gly Thr Lys Thr Gly Gly Phe Glu Phe Phe Pro Ile

265 270 275gcg atg aag ccg ggt aaa ccg caa ggt cat ggg cag tgg ggc gac gca 979Ala Met Lys Pro Gly Lys Pro Gln Gly His Gly Gln Trp Gly Asp Ala

280 285 290aaa gtg gtg tgt ctg ccg gga aac ccg gtg gcg gcg tgg gtt agt ttt 1027Lys Val Val Cys Leu Pro Gly Asn Pro Val Ala Ala Trp Val Ser Phe

295 300 305agg ctc ttt gtt gtt ccg gta att gag aga tta ggg ggt gga aag agg 1075Arg Leu Phe Val Val Pro Val Ile Glu Arg Leu Gly Gly Gly Lys Arg310 315 320 325ctg gcg tcg ata agc gaa ctc cct gtg gtg gcg ctg cgc tcg aac cgg 1123Leu Ala Ser Ile Ser Glu Leu Pro Val Val Ala Leu Arg Ser Asn Arg

330 335 340gcg ctg aag gcg cgg gag ggc ccc gta ttg gcg ata ccg gtg gcg att 1171Ala Leu Lys Ala Arg Glu Gly Pro Val Leu Ala Ile Pro Val Ala Ile

345 350 355gat tgg gag aaa aga atg gca aat tct cag gca cat cga tcc cat atg 1219Asp Trp Glu Lys Arg Met Ala Asn Ser Gln Ala His Arg Ser His Met

360 365 370gtc ggt gca ctg gct gga agt ggc ggt att gca ctg gtg act tcg tcg 1267Val Gly Ala Leu Ala Gly Ser Gly Gly Ile Ala Leu Val Thr Ser Ser

375380385 att gcc gag gac ggt ctg gtt gat gtt gtg ctg ggg aga atg 1309Ile Ala Glu Asp Gly Leu Val Asp Val Val Leu Gly Arg Met 390395400 taaatgaata tcatcattct tgc 1332<210>776<211>403<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>776Val Ala Gln Gln Arg Ser Val Asp Asp Tyr Leu Ser Ile Leu Ile Asp 151015 Ser Val Ala Pro Leu Pro Pro Val Lys Thr Pro Ile Leu Gly Ala His

20 25 30Pro Leu Ser His Leu Ala Glu Asp Val Val Ala Thr Ile Pro Ile Pro

35 40 45Lys Phe Thr Asn Ser Ala Val Asp Gly Tyr Ala Ile Leu Lys Glu Asp

50 55 60Ile His Gly Ser Gly Pro Trp Thr Phe Leu Val Gly Gly Asp Thr Pro 65 70 75 80Ala Gly Ser Ala Pro Ala Ser Ile Asn Asn Gly Lys Ala Ile Arg Val

85 90 95Met Thr Gly Gly Pro Val Pro Ser Thr Asn Lys Asp Met Ile Val Val

100 105 110Pro Val Glu Leu Thr Asn Ala Pro Val Asp His Ser Leu Pro Thr Glu

115 120 125Ile Thr Ile Asn Glu Leu Pro Gly Glu Arg Asn Asn Ile Arg His Ala

130 135 140Gly Glu His Leu Lys Glu Gly Glu Ile Ala Val Ala Ala Gly Thr Ala145 150 155 160Phe Asp Ala Gly Thr Val Ser Thr Val Ile Ser Val Gly His Asp Thr

165 170 175Val Lys Ala His Pro Cys Pro Arg Val Ala Val Ile Thr Thr Gly Asp

180185 190Glu Leu Asn Gln Gly Asn Pro Trp Gly Ile Pro Asn Ser Asn Gly Pro

195 200 205Met Leu Val Ala Glu Leu Lys Arg Val Gly Ile Lys Asp Pro Gln His

210 215 220Phe His Ser Asp Asp Ser Glu Thr Ala Leu Arg Glu Thr Leu Asp Lys225 230 235 240Pro Ala Glu Val Ala Asp Val Ile Ile Thr Val Gly Gly Ile Ser Ala

245 250 255Gly Ala Phe Asp Val Val Lys Ala Val Gly Thr Lys Thr Gly Gly Phe

260 265 270Glu Phe Phe Pro Ile Ala Met Lys Pro Gly Lys Pro Gln Gly His Gly

275 280 285Gln Trp Gly Asp Ala Lys Val Val Cys Leu Pro Gly Asn Pro Val Ala

290 295 300Ala Trp Val Ser Phe Arg Leu Phe Val Val Pro Val Ile Glu Arg Leu305 310 315 320Gly Gly Gly Lys Arg Leu Ala Ser Ile Ser Glu Leu Pro Val Val Ala

325 330 335Leu Arg Ser Asn Arg Ala Leu Lys Ala Arg Glu Gly Pro Val Leu Ala

340 345 350Ile Pro Val Ala Ile Asp Trp Glu Lys Arg Met Ala Asn Ser Gln Ala

355 360 365His Arg Ser His Met Val Gly Ala Leu Ala Gly Ser Gly Gly Ile Ala

370375380 Leu Val Thr Ser Ser Ile Ala Glu Asp Gly Leu Val Asp Val Val Leu 385390395400 Gly Arg Met<210>777<211>1237<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(2). (1207)<223>RXS03223<400>777t cca gag cca gtg cgt att gct att gca gag gca ctg ggt ttg atg tgc 49 Pro Glu Pro Val Arg Ile Ala Ile Ala Glu Ala Leu Gly Leu Met Cys

1 5 10 15gcg gaa gag gtt caa gct agt cgt gct ttg ccg ggt ttc gcg caa gca 97Ala Glu Glu Val Gln Ala Ser Arg Ala Leu Pro Gly Phe Ala Gln Ala

20 25 30gcg att gat ggt tat gcg gtt cga gca gtc gat gtc ggc ggc gag aag 145Ala Ile Asp Gly Tyr Ala Val Arg Ala Val Asp Val Gly Gly Glu Lys

35 40 45tcg ttt agc cag caa ctg ccg gtt gct cct ccg gaa aaa tcc ctg ccc 193Ser Phe Ser Gln Gln Leu Pro Val Ala Pro Pro Glu Lys Ser Leu Pro

50 55 60gtg gtg ggt gaa gta gct gcg ggt tct cag cag ccg ttg cgc ctg cag 241Val Val Gly Glu Val Ala Ala Gly Ser Gln Gln Pro Leu Arg Leu Gln 65 70 75 80cct aaa caa gca gtc atg gtc cac acc ggt gcg cca ctg ccg atg ctt 289Pro Lys Gln Ala Val Met Val His Thr Gly Ala Pro Leu Pro Met Leu

85 90 95gcg gat gcg gtg ctg ccc atg gcg tgg tca gat cgt ggc cgc aaa cga 337Ala Asp Ala Val Leu Pro Met Ala Trp Ser Asp Arg Gly Arg Lys Arg

100 105 110gta acc gcg cag cga cct gtg cgc tct ggc gag ttt gtg cgc aaa gaa 385Val Thr Ala Gln Arg Pro Val Arg Ser Gly Glu Phe Val Arg Lys Glu

115 120 125ggc gat gac atc caa ccg gga gac atc gca gtc agc gcc ggc gcg gtc 433Gly Asp Asp Ile Gln Pro Gly Asp Ile Ala Val Ser Ala Gly Ala Val

130 135 140tta ggc cct gcc caa att ggt ttg ctc gca gct gtt ggt cgc tcc aaa 481Leu Gly Pro Ala Gln Ile Gly Leu Leu Ala Ala Val Gly Arg Ser Lys145 150 155 160gtg ttg gtg tac cca cgc cca cgc atg tcg gtt atc tcc gta ggc gct 529Val Leu Val Tyr Pro Arg Pro Arg Met Ser Val Ile Ser Val Gly Ala

165 170 175gaa ctt gtt gat att gat cgc cag cca ggc ctc ggc cag gtt tat gat 577Glu Leu Val Asp Ile Asp Arg Gln Pro Gly Leu Gly Gln Val Tyr Asp

180 185 190gtc aat tcc tat tct ctg gct gcc gcc ggt agg gaa gcg ggc gca gat 625Val Asn Ser Tyr Ser Leu Ala Ala Ala Gly Arg Glu Ala Gly Ala Asp

195 200 205gtg tac cgc tac ggc att gct gcc ggt gaa cct cgt cgc atc aaa gag 673Val Tyr Arg Tyr Gly Ile Ala Ala Gly Glu Pro Arg Arg Ile Lys Glu

210 215 220atc att gaa tcc cag atg ctg cgc tcg gaa atc atc gtc atc acc gga 721Ile Ile Glu Ser Gln Met Leu Arg Ser Glu Ile Ile Val Ile Thr Gly225 230 235 240gct gtt ggc ggt gct ggt tca gct ggc gtg cgc cag gtt ctc aac gag 769Ala Val Gly Gly Ala Gly Ser Ala Gly Val Arg Gln Val Leu Asn Glu

245 250 255cta ggc gat atc gac acc gaa cgc gtc gca atg cac ccc ggt tct gtc 817Leu Gly Asp Ile Asp Thr Glu Arg Val Ala Met His Pro Gly Ser Val

260 265 270caa gga ttc ggt ctg ctc ggc gag aac aag att cca tgc ttc ctt ctg 865Gln Gly Phe Gly Leu Leu Gly Glu Asn Lys Ile Pro Cys Phe Leu Leu

275 280 285cct tcc aat ccg gtg gcg tcg tta gtt att ttt gaa acc ttc gtc cgc 913Pro Ser Asn Pro Val Ala Ser Leu Val Ile Phe Glu Thr Phe Val Arg

290 295 300ccg gtc gtg cgc atg agc ctg ggc aag agc aat gcg gcg cgc cgg gtt 961Pro Val Val Arg Met Ser Leu Gly Lys Ser Asn Ala Ala Arg Arg Val305 310 315 320gtt cga gct cga gcg ctc aac cac gtt gtg tct gtg gcg ggt cga aaa 1009Val Arg Ala Arg Ala Leu Asn His Val Val Ser Val Ala Gly Arg Lys

325 330 335ggt ttc atc agg tcc agg ctc atg cgc gat gca gaa acc cag gac tac 1057Gly Phe Ile Arg Ser Arg Leu Met Arg Asp Ala Glu Thr Gln Asp Tyr

340 345 350ctc gtg gag gct ttg ggt ggt gca acg ggc gca cca tcg cac cta ttg 1105Leu Val Glu Ala Leu Gly Gly Ala Thr Gly Ala Pro Ser His Leu Leu

355 360 365gca gga ttg tcc gaa gca aac ggt atg atc cgc att cca gaa gat gtc 1153Ala Gly Leu Ser Glu Ala Asn Gly Met Ile Arg Ile Pro Glu Asp Val

370375380 aca gaa atc cga ccg gga gat gtc gtg gac gtg atc ttc ctt gcc caa 1201Thr Glu Ile Arg Pro Gly Asp Val Val Asp Val Ile Phe Leu Ala Gln 385390395400 ggt cga tagttcgatg cgtaatgcac cgtcaggtcc 1237Gly Arg<210>778<211>402<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>778Pro Glu Pro Val Arg Ile Ala Ile Ala Glu Ala Leu Gly Leu Met Cys 151015 Ala Glu Glu Val Gln Ala Ser Arg Ala Leu Pro Gly Phe Ala Gln Ala

20 25 30Ala Ile Asp Gly Tyr Ala Val Arg Ala Val Asp Val Gly Gly Glu Lys

35 40 45Ser Phe Ser Gln Gln Leu Pro Val AlaPro Pro Glu Lys Ser Leu Pro

50 55 60Val Val Gly Glu Val Ala Ala Gly Ser Gln Gln Pro Leu Arg Leu Gln 65 70 75 80Pro Lys Gln Ala Val Met Val His Thr Gly Ala Pro Leu Pro Met Leu

85 90 95Ala Asp Ala Val Leu Pro Met Ala Trp Ser Asp Arg Gly Arg Lys Arg

100 105 110Val Thr Ala Gln Arg Pro Val Arg Ser Gly Glu Phe Val Arg Lys Glu

115 120 125Gly Asp Asp Ile Gln Pro Gly Asp Ile Ala Val Ser Ala Gly Ala Val

130 135 140Leu Gly Pro Ala Gln Ile Gly Leu Leu Ala Ala Val Gly Arg Ser Lys145 150 155 160Val Leu Val Tyr Pro Arg Pro Arg Met Ser Val Ile Ser Val Gly Ala

165 170 175Glu Leu Val Asp Ile Asp Arg Gln Pro Gly Leu Gly Gln Val Tyr Asp

180 185 190Val Asn Ser Tyr Ser Leu Ala Ala Ala Gly Arg Glu Ala Gly Ala Asp

195 200 205Val Tyr Arg Tyr Gly Ile Ala Ala Gly Glu Pro Arg Arg Ile Lys Glu

210 215 220Ile Ile Glu Ser Gln Met Leu Arg Ser Glu Ile Ile Val Ile Thr Gly225 230 235 240Ala Val Gly Gly Ala Gly Ser Ala Gly Val Arg Gln Val Leu Asn Glu

245 250 255Leu Gly Asp Ile Asp Thr Glu Arg Val Ala Met His Pro Gly Ser Val

260 265 270Gln Gly Phe Gly Leu Leu GlyGlu Asn Lys Ile Pro Cys Phe Leu Leu

275 280 285Pro Ser Asn Pro Val Ala Ser Leu Val Ile Phe Glu Thr Phe Val Arg

290 295 300Pro Val Val Arg Met Ser Leu Gly Lys Ser Asn Ala Ala Arg Arg Val305 310 315 320Val Arg Ala Arg Ala Leu Asn His Val Val Ser Val Ala Gly Arg Lys

325 330 335Gly Phe Ile Arg Ser Arg Leu Met Arg Asp Ala Glu Thr Gln Asp Tyr

340 345 350Leu Val Glu Ala Leu Gly Gly Ala Thr Gly Ala Pro Ser His Leu Leu

355 360 365Ala Gly Leu Ser Glu Ala Asn Gly Met Ile Arg Ile Pro Glu Asp Val

370375380 Thr Glu Ile Arg Pro Gly Asp Val Val Asp Val Ile Phe Leu Ala Gln 385390395400 Gly Arg<210>779<211>1229<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (1206)<223>FRXA01970<400>77 779cca gag cca gtg cgt att gct att gca gag gca ctg ggt ttg atg tgc 48Pro Glu Pro Val Arg Ile Ala Ile Ala Glu Ala Leu Gly Leu Met Cys 151015 gcg gaa gag gtt caa gct agt cgt gct ttg ccg ggt ttc gcg caa gca 96Ala Glu Glu Val Gln Ala Ser Arg Ala Leu Pro Gly Phe Ala Gln Ala

20 25 30gcg att gat ggt tat gcg gtt cga gca gtc gat gtc ggc ggc gag aag 144Ala Ile Asp Gly Tyr Ala Val Arg Ala Val Asp Val Gly Gly Glu Lys

35 40 45tcg ttt agc cag caa ctg ccg gtt gct cct ccg gaa aaa tcc ctg ccc 192Ser Phe Ser Gln Gln Leu Pro Val Ala Pro Pro Glu Lys Ser Leu Pro

50 5560gtg gtg ggt gaa gta gct gcg ggt tct cag cag ccg ttg cgc ctg cag 240Val Val Gly Glu Val Ala Ala Gly Ser Gln Gln Pro Leu Arg Leu Gln 65 70 75 80cct aaa caa gca gtc atg gtc cac acc ggt gcg cca ctg ccg atg ctt 288Pro Lys Gln Ala Val Met Val His Thr Gly Ala Pro Leu Pro Met Leu

85 90 95gcg gat gcg gtg ctg ccc atg gcg tgg tca gat cgt ggc cgc aaa cga 336Ala Asp Ala Val Leu Pro Met Ala Trp Ser Asp Arg Gly Arg Lys Arg

100 105 110gta acc gcg cag cga cct gtg cgc tct ggc gag ttt gtg cgc aaa gaa 384Val Thr Ala Gln Arg Pro Val Arg Ser Gly Glu Phe Val Arg Lys Glu

115 120 125ggc gat gac atc caa ccg gga gac atc gca gtc agc gcc ggc gcg gtc 432Gly Asp Asp Ile Gln Pro Gly Asp Ile Ala Val Ser Ala Gly Ala Val

130 135 140tta ggc cct gcc caa att ggt ttg ctc gca gct gtt ggt cgc tcc aaa 480Leu Gly Pro Ala Gln Ile Gly Leu Leu Ala Ala Val Gly Arg Ser Lys145 150 155 160gtg ttg gtg tac cca cgc cca cgc atg tcg gtt atc tcc gta ggc gct 528Val Leu Val Tyr Pro Arg Pro Arg Met Ser Val Ile Ser Val Gly Ala

165 170 175gaa ctt gtt gat att gat cgc cag cca ggc ctc ggc cag gtt tat gat 576Glu Leu Val Asp Ile Asp Arg Gln Pro Gly Leu Gly Gln Val Tyr Asp

180 185 190gtc aat tcc tat tct ctg gct gcc gcc ggt agg gaa gcg ggc gca gat 624Val Asn Ser Tyr Ser Leu Ala Ala Ala Gly Arg Glu Ala Gly Ala Asp

195 200 205gtg tac cgc tac ggc att gct gcc ggt gaa cct cgt cgc atc aaa gag 672Val TyrArg Tyr Gly Ile Ala Ala Gly Glu Pro Arg Arg Ile Lys Glu

210 215 220atc att gaa tcc cag atg ctg cgc tcg gaa atc atc gtc atc acc gga 720Ile Ile Glu Ser Gln Met Leu Arg Ser Glu Ile Ile Val Ile Thr Gly225 230 235 240gct gtt ggc ggt gct ggt tca gct ggc gtg cgc cag gtt ctc aac gag 768Ala Val Gly Gly Ala Gly Ser Ala Gly Val Arg Gln Val Leu Asn Glu

245 250 255cta ggc gat atc gac acc gaa cgc gtc gca atg cac ccc ggt tct gtc 816Leu Gly Asp Ile Asp Thr Glu Arg Val Ala Met His Pro Gly Ser Val

260 265 270caa gga ttc ggt ctg ctc ggc gag aac aag att cca tgc ttc ctt ctg 864Gln Gly Phe Gly Leu Leu Gly Glu Asn Lys Ile Pro Cys Phe Leu Leu

275 280 285cct tcc aat ccg gtg gcg tcg tta gtt att ttt gaa acc ttc gtc cgc 912Pro Ser Asn Pro Val Ala Ser Leu Val Ile Phe Glu Thr Phe Val Arg

290 295 300ccg gtc gtg cgc atg agc ctg ggc aag agc aat gcg gcg cgc cgg gtt 960Pro Val Val Arg Met Ser Leu Gly Lys Ser Asn Ala Ala Arg Arg Val305 310 315 320gtt cga gct cga gcg ctc aac cac gtt gtg tct gtg gcg ggt cga aaa 1008Val Arg Ala Arg Ala Leu Asn His Val Val Ser Val Ala Gly Arg Lys

325 330 335ggt ttc atc agg tcc agg ctc atg cgc gat gca gaa acc cag gac tac 1056Gly Phe Ile Arg Ser Arg Leu Met Arg Asp Ala Glu Thr Gln Asp Tyr

340 345 350ctc gtg gag gct ttg ggt ggt gca acg ggc gca cca tcg cac cta ttg 1104Leu Val Glu Ala Leu Gly Gly Ala Thr Gly Ala Pro Ser His Leu Leu

355 360 365gca gga ttg tcc gaa gca aac ggt atg atc cgc att cca gaa gat gtc 1152Ala Gly Leu Ser Glu Ala Asn Gly Met Ile Arg Ile Pro Glu Asp Val

370375380 aca gaa atc cga ccg gga gat gtc gtg gac gtg atc ttc ctt gcc caa 1200Thr Glu Ile Arg Pro Gly Asp Val Val Asp Val Ile Phe Leu Ala Gln 385390395400 ggt cga tagttcgatg cgtaatgcac cgt 1229Gly Arg<210>780<211>402<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>780Pro Glu Pro Val Arg Ile Ala Ile Ala Glu Ala Leu Gly Leu Met Cys 151015 Ala Glu Glu Val Gln Ala Ser Arg Ala Leu Pro Gly Phe Ala Gln Ala

20 25 30Ala Ile Asp Gly Tyr Ala Val Arg Ala Val Asp Val Gly Gly Glu Lys

35 40 45Ser Phe Ser Gln Gln Leu Pro Val Ala Pro Pro Glu Lys Ser Leu Pro

50 55 60Val Val Gly Glu Val Ala Ala Gly Ser Gln Gln Pro Leu Arg Leu Gln 65 70 75 80Pro Lys Gln Ala Val Met Val His Thr Gly Ala Pro Leu Pro Met Leu

85 90 95Ala Asp Ala Val Leu Pro Met Ala Trp Ser Asp Arg Gly Arg Lys Arg

100 105 110Val Thr Ala Gln Arg Pro Val Arg Ser Gly Glu Phe Val Arg Lys Glu

115 120 125Gly Asp Asp Ile Gln Pro Gly Asp Ile Ala Val Ser Ala Gly Ala Val

130 135 140Leu Gly Pro Ala Gln Ile Gly Leu Leu Ala Ala Val Gly Arg Ser Lys145 150 155 160Val Leu Val Tyr Pro Arg Pro Arg Met Ser Val Ile Ser Val Gly Ala

165 170 175Glu Leu Val Asp Ile Asp Arg Gln Pro Gly Leu Gly Gln Val Tyr Asp

180 185 190Val Asn Ser Tyr Ser Leu Ala Ala Ala Gly Arg Glu Ala Gly Ala Asp

195 200 205Val Tyr Arg Tyr Gly Ile Ala Ala Gly Glu Pro Arg Arg Ile Lys Glu

210 215 220Ile Ile Glu Ser Gln Met Leu Arg Ser Glu Ile Ile Val Ile Thr Gly225 230 235 240Ala Val Gly Gly Ala Gly Ser Ala Gly Val Arg Gln Val Leu Asn Glu

245 250 255Leu Gly Asp Ile Asp Thr Glu Arg Val Ala Met His Pro Gly Ser Val

260 265 270Gln Gly Phe Gly Leu Leu Gly Glu Asn Lys Ile Pro Cys Phe Leu Leu

275 280 285Pro Ser Asn Pro Val Ala Ser Leu Val Ile Phe Glu Thr Phe Val Arg

290 295 300Pro Val Val Arg Met Ser Leu Gly Lys Ser Asn Ala Ala Arg Arg Val305 310 315 320Val Arg Ala Arg Ala Leu Asn His Val Val Ser Val Ala Gly Arg Lys

325 330 335Gly Phe Ile Arg Ser Arg Leu Met Arg Asp Ala Glu Thr Gln Asp Tyr

340 345 350Leu Val Glu Ala Leu Gly Gly Ala Thr Gly Ala Pro Ser His Leu Leu

355 360 365Ala Gly Leu Ser Glu Ala Asn Gly Met Ile Arg Ile Pro Glu Asp Val

370375380 Thr Glu Ile Arg Pro Gly Asp Val Val Asp Val Ile Phe Leu Ala Gln 385390395400 Gly Arg<210>781<211>708<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (685)<223>RXA02629<400>781tacctcgcag agccgggagg tagaggttac tctgacgagt gagtaggttt aaaagagtta 60atctgcatct aatcaagtag ccaagtatga gtgaggaaca atg agc aag gat cca 115

Met Ser Lys Asp Pro

1 5ttg gga agt ctt acc gat gtt gta gac aca cga gtt ccg ctt ccg gat 163Leu Gly Ser Leu Thr Asp Val Val Asp Thr Arg Val Pro Leu Pro Asp

10 15 20gtt gaa ccg gat ccg gag ttc ctg aag gct acg gaa aaa gaa ttc cac 211Val Glu Pro Asp Pro Glu Phe Leu Lys Ala Thr Glu Lys Glu Phe His

25 30 35atg gca tcc cag aag cgc gct ctt gtt gtc ctg gtg ggc gat cat gtc 259Met Ala Ser Gln Lys Arg Ala Leu Val Val Leu Val Gly Asp His Val

40 45 50gct gag gca gat ggg act ggc cgt ttg gtt acg gag ctg ctc tta gag 307Ala Glu Ala Asp Gly Thr Gly Arg Leu Val Thr Glu Leu Leu Leu Glu

55 60 65tct ggc ttc aac gtg gac gct gtg gtc agc gtg aag tct aag aag tct 355Ser Gly Phe Asn Val Asp Ala Val Val Ser Val Lys Ser Lys Lys Ser 70 75 80 85cag att agg caa gct att gaa acc gca gtt gtt ggc ggc gct gac ctt 403Gln Ile Arg Gln Ala Ile Glu Thr Ala Val Val Gly Gly Ala Asp Leu

90 95 100gtg ctg acc atc ggc gga gtg ggc gtt ggt cct cgg gat aaa act cct 451Val Leu Thr Ile Gly Gly Val Gly Val Gly Pro Arg Asp Lys Thr Pro

105 110 115gaggca acc agc gct gtg ttg gac cag gac gtc cca gga atc gcg cag 499Glu Ala Thr Ser Ala Val Leu Asp Gln Asp Val Pro Gly Ile Ala Gln

120 125 130gcg ctt cgt tcc tcc ggt ttg gcc tgt ggc gcg gtg gat gca agt gtt 547Ala Leu Arg Ser Ser Gly Leu Ala Cys Gly Ala Val Asp Ala Ser Val

135 140 145tcc cga ggc gta gcg ggc gta tcc ggc tca acc gtg gtg gtc aac ctc 595

Ser Arg Gly Val Ala Gly Val Ser Gly Ser Thr Val Val Val Asn Leu150 155 160 165gct gag tct cgt tcg gca att cgt gat ggc atg gca act ctg aca ccg 643Ala Glu Ser Arg Ser Ala Ile Arg Asp Gly Met Ala Thr Leu Thr Pro

170 175 180ttg gtt gat ttt gtt gta gat cag ctt cgc act tcc gtg gtt 685Leu Val Asp Phe Val Val Asp Gln Leu Arg Thr Ser Val Val

185190195 tgagttggtc gggtgtgagt aga 708<210>782<211>195<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>782Met Ser Lys Asp Pro Leu Gly Ser Leu Thr Asp Val Val Asp Thr Arg 151015 Val Pro Leu Pro Asp Val Glu Pro Asp Pro Glu Phe Leu Lys Ala Thr

20 25 30Glu Lys Glu Phe His Met Ala Ser Gln Lys Arg Ala Leu Val Val Leu

35 40 45Val Gly Asp His Val Ala Glu Ala Asp Gly Thr Gly Arg Leu Val Thr

50 55 60Glu Leu Leu Leu Glu Ser Gly Phe Asn Val Asp Ala Val Val Ser Val 65 70 75 80Lys Ser Lys Lys Ser Gln Ile Arg Gln Ala Ile Glu Thr Ala Val Val

85 90 95Gly Gly Ala Asp Leu Val Leu Thr Ile Gly Gly Val Gly Val Gly Pro

100 105 110Arg Asp Lys Thr Pro Glu Ala Thr Ser Ala Val Leu Asp Gln Asp Val

115 120 125Pro Gly Ile Ala Gln Ala Leu Arg Ser Ser Gly Leu Ala Cys Gly Ala

130 135 140Val Asp Ala Ser Val Ser Arg Gly Val Ala Gly Val Ser Gly Ser Thr145 150 155 160Val Val Val Asn Leu Ala Glu Ser Arg Ser Ala Ile Arg Asp Gly Met

165 170 175Ala Thr Leu Thr Pro Leu Val Asp Phe Val Val Asp Gln Leu Arg Thr

180 185 190Ser Val Val

195<210>783<211>402<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (379)<223>RXA02318<400>783gatatacgcc acggtaccgc gtacaaaatc ccgaatatga tcatggccaa aggaggtcag 60cagtaagcgc atgtgcgcca ttttaaggca agatggggcc atg aat tcg ctt ttc 115

Met Asn Ser Leu Phe

1 5gac gtc tcc cca cac tgg tcc tcc gcc aac gcc aag ctc acc gca cat 163Asp Val Ser Pro His Trp Ser Ser Ala Asn Ala Lys Leu Thr Ala His

10 15 20ttt aac acc gga aaa ttc tcc act ggc atg aaa ttt gtc aac ctc att 211Phe Asn Thr Gly Lys Phe Ser Thr Gly Met Lys Phe Val Asn Leu Ile

25 30 35gcc gac tcc gca gaa gaa gcc aac cac cac ccc gat atc ctt ctc acc 259Ala Asp Ser Ala Glu Glu Ala Asn His His Pro Asp Ile Leu Leu Thr

40 45 50tat ggt ttt gtg gaa atc acc ctc acc agc cac gat gtg ggt gag ata 307Tyr Gly Phe Val Glu Ile Thr Leu Thr Ser His Asp Val Gly Glu Ile

55 60 65acc gac cgt gat gtc gcc cta gca aaa gtc atc gac gcc cac gcc aag 355Thr Asp Arg Asp Val Ala Leu Ala Lys Val Ile Asp Ala His Ala Lys 70 75 80 85acc ttg gcc att tcg gca gag gct taaggttaaa gattatgagc aac 402Thr Leu Ala Ile Ser Ala Glu Ala

90<210>784<211>93<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>784Met Asn Ser Leu Phe Asp Val Ser Pro His Trp Ser Ser Ala Asn Ala 151015 Lys Leu Thr Ala His Phe Asn Thr Gly Lys Phe Ser Thr Gly Met Lys

20 25 30Phe Val Asn Leu Ile Ala Asp Ser Ala Glu Glu Ala Asn His His Pro

35 40 45Asp Ile Leu Leu Thr Tyr Gly Phe Val Glu Ile Thr Leu Thr Ser His

50 55 60Asp Val Gly Glu Ile Thr Asp Arg Asp Val Ala Leu Ala Lys Val Ile 65 70 75 80Asp Ala His Ala Lys Thr Leu Ala Ile Ser Ala Glu Ala

8590<210>785<211>600<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (577)<223>RXA01517<400>785tccataagcc caaagcaccg atcccacgta cttttgctga cgtcgcggtg gttgcccgac 60gttccaggaa atccatggct gctggaagga gcaacgccta atg cat gca gtt ttg 115

Met His Ala Val Leu

1 5tcc atc ggt tcc aac atg gat gat cgc tac gcg ctg ctc aac aca gtg 163Ser Ile Gly Ser Asn Met Asp Asp Arg Tyr Ala Leu Leu Asn Thr Val

10 15 20atc gag gaa ttc aaa gat gag atc gtg gcg cag tct gcg atc tac tca 211Ile Glu Glu Phe Lys Asp Glu Ile Val Ala Gln Ser Ala Ile Tyr Ser

25 30 35acc cca ccg tgg ggc att gag gat cag gat gaa ttc ctc aac gca gtg 259Thr Pro Pro Trp Gly Ile Glu Asp Gln Asp Glu Phe Leu Asn Ala Val

40 45 50ctc gtt gtt gag gtt gaa gaa acc ccc atc gag ttg ctg cgc cgt ggc 307Leu Val Val Glu Val Glu Glu Thr Pro Ile Glu Leu Leu Arg Arg Gly

55 60 65caa aaa ctc gaa gaa gcc gcc gag cgg gtc cgc gtc cgc aaa tgg ggg 355Gln Lys Leu Glu Glu Ala Ala Glu Arg Val Arg Val Arg Lys Trp Gly 70 75 80 85 cca cgc acc ctc gat gtg gat atc gtg cag atc att aaa gat ggg gaa 403Pro Arg Thr Leu Asp Val Asp Ile Val Gln Ile Ile Lys Asp Gly Glu

90 95 100gag atc ctt tct gag gat ccc gaa ctg acc ttg cca cac cct tgg gct 451Glu Ile Leu Ser Glu Asp Pro Glu Leu Thr Leu Pro His Pro Trp Ala

105 110 115tgg cag cgt gcc ttc gtg ttg atc cct tgg ttg gaa gca gaa cct gat 499Trp Gln Arg Ala Phe Val Leu Ile Pro Trp Leu Glu Ala Glu Pro Asp

120 125 130gcc gtc ctg cac ggc acg acc att gca gaa cat gtg gat aat ctt gat 547Ala Val Leu His Gly Thr Thr Ile Ala Glu His Val Asp Asn Leu Asp

135140145 ccc aca gac att gaa ggt gtc acc aag att taaggagtcg tggctttcat 597Pro Thr Asp Ile Glu Gly Val Thr Lys Ile 150155 gca 600<210>786<211>159<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>786Met His Ala Val Leu Ser Ile Gly Ser Asn Met Asp Asp Arg Tyr Ala 151015 Leu Leu Asn Thr Val Ile Glu Glu Phe Lys Asp Glu Ile Val Ala Gln

20 25 30Ser Ala Ile Tyr Ser Thr Pro Pro Trp Gly Ile Glu Asp Gln Asp Glu

35 40 45Phe Leu Asn Ala Val Leu Val Val Glu Val Glu Glu Thr Pro Ile Glu

50 55 60Leu Leu Arg Arg Gly Gln Lys Leu Glu Glu Ala Ala Glu Arg Val Arg 65 70 75 80Val Arg Lys Trp Gly Pro Arg Thr Leu Asp Val Asp Ile Val Gln Ile

85 90 95Ile Lys Asp Gly Glu Glu Ile Leu Ser Glu Asp Pro Glu Leu Thr Leu

100 105 110Pro His Pro Trp Ala Trp Gln Arg Ala Phe Val Leu Ile Pro Trp Leu

115 120 125Glu Ala Glu Pro Asp Ala Val Leu His Gly Thr Thr Ile Ala Glu His

130135140 Val Asp Asn Leu Asp Pro Thr Asp Ile Glu Gly Val Thr Lys Ile 145150155<210>787<211>609<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (586)<223>RXN01304<400>787atgcaggtaa acgaatttgt gcttatatca acattcgtga ttcggcaaaa ttaattaaac 60tgaaaaaggg gattaattac ccccacttga ggagaaattg atg ccc gca cag aac 115

Met Pro Ala Gln Asn

1 5aaa aac ctc cca gga tcc gtc atc gtt gtg tct gat cgg att aaa tcg 163Lys Asn Leu Pro Gly Ser Val Ile Val Val Ser Asp Arg Ile Lys Ser

10 15 20gga gaa aga att gat aaa gca gga ccc gta gca gta gac ctt ctt cag 211Gly Glu Arg Ile Asp Lys Ala Gly Pro Val Ala Val Asp Leu Leu Gln

25 30 35gaa tca ggc gtg gag att tcc aca ttc acc gtc gtg gag gag ggc ttt 259Glu Ser Gly Val Glu Ile Ser Thr Phe Thr Val Val Glu Glu Gly Phe

40 45 50gaa cct gtc cat caa gaa ttg gtt aag gcg ttg gcg cgc cgg gat cgc 307Glu Pro Val His Gln Glu Leu Val Lys Ala Leu Ala Arg Arg Asp Arg

55 60 65gtc atc atc acc atc ggc gga acg ggc gtg ggg cct aga aat cgg acg 355Val Ile Ile Thr Ile Gly Gly Thr Gly Val Gly Pro Arg Asn Arg Thr 70 75 80 85ccg gag gcc aca gaa ccg cac atc gat acg cta ctg ccg ggt ctg atg 403Pro Glu Ala Thr Glu Pro His Ile Asp Thr Leu Leu Pro Gly Leu Met

90 95 100acg cag att ttg ttc tct gga ctg tcc aat acc gcg cag gcg ggg tta 451Thr Gln Ile Leu Phe Ser Gly Leu Ser Asn Thr Ala Gln Ala Gly Leu

105 110 115tct cgg ggg ctg gtg ggc ttg agt gct cgc gat tcc acg gcc gcg ctc 499Ser Arg Gly Leu Val Gly Leu Ser Ala Arg Asp Ser Thr Ala Ala Leu

120 125 130atc gtc aac gcg ccg agt tct tcc ggg ggc gtg cgc gac gcg ctc ggg 547Ile Val Asn Ala Pro Ser Ser Ser Gly Gly Val Arg Asp Ala Leu Gly

135140145 gtg gtc tgc ccg ctt ttc ggt tcc att ttt gag cgt ctt taaaagattt 596Val Val Cys Pro Leu Phe Gly Ser Ile Phe Glu Arg Leu 150155160 ttgcttatcg acg 609<210>788<211>162<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>788Met Pro Ala Gln Asn Lys Asn Leu Pro Gly Ser Val Ile Val Val Ser 151015 Asp Arg Ile Lys Ser Gly Glu Arg Ile Asp Lys Ala Gly Pro Val Ala

20 25 30Val Asp Leu Leu Gln Glu Ser Gly Val Glu Ile Ser Thr Phe Thr Val

35 40 45Val Glu Glu Gly Phe Glu Pro Val His Gln Glu Leu Val Lys Ala Leu

50 55 60Ala Arg Arg Asp Arg Val Ile Ile Thr Ile Gly Gly Thr Gly Val Gly 65 70 75 80Pro Arg Asn Arg Thr Pro Glu Ala Thr Glu Pro His Ile Asp Thr Leu

85 90 95Leu Pro Gly Leu Met Thr Gln Ile Leu Phe Ser Gly Leu Ser Asn Thr

100 105 110 Ala Gln Ala Gly Leu Ser Arg Gly Leu Val Gly Leu Ser Ala Arg Asp

115 120 125Ser Thr Ala Ala Leu Ile Val Asn Ala Pro Ser Ser Ser Gly Gly Val

130135140 Arg Asp Ala Leu Gly Val Val Cys Pro Leu Phe Gly Ser Ile Phe Glu 145150155160 Arg Leu<210>789<211>1281<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1258)<223>RXS02556<400>789tgccatcata ttaaggccaa attgcttgga tcctgggatt tatttaatta gattaaatcc 60gtagaaatta gcccatgaag catggaaagg cgaaaacccc ttg atc gtt tcc acc 115

Leu Ile Val Ser Thr

1 5cag ccc att act gat cgc agc gca ctc tcg gca gaa cac gca gag gtg 163GlnPro Ile Thr Asp Arg Ser Ala Leu Ser Ala Glu His Ala Glu Val

10 15 20atc aaa gca acg ctt cct ctc gtg ggc ggc aag att aat gag atc acg 211Ile Lys Ala Thr Leu Pro Leu Val Gly Gly Lys Ile Asn Glu Ile Thr

25 30 35ccg gtt ttc tac aac aag atg ttt gcg gct cac cca gaa ttg atc gct 259Pro Val Phe Tyr Asn Lys Met Phe Ala Ala His Pro Glu Leu Ile Ala

40 45 50aac acc ttc aac cgt ggc aat cag aag caa ggc gat cag cag aag gcg 307Asn Thr Phe Asn Arg Gly Asn Gln Lys Gln Gly Asp Gln Gln Lys Ala

55 60 65ctg gcg gct tcg att gca acg ttt gcc acc atg ctc gtt act cct gat 355Leu Ala Ala Ser Ile Ala Thr Phe Ala Thr Met Leu Val Thr Pro Asp 70 75 80 85gct cct gac cca gtt cag ctg ctg tcc cgc att ggc cac aag cac gtg 403Ala Pro Asp Pro Val Gln Leu Leu Ser Arg Ile Gly His Lys His Val

90 95 100tcc ctc ggc att act gct gat cag tac gac att gtt cac gag cac ctg 451Ser Leu Gly Ile Thr Ala Asp Gln Tyr Asp Ile Val His Glu His Leu

105 110 115ttc gcc gca atc gtt gag gtt ttg gga gcg gaa act gtc acc gca cct 499Phe Ala Ala Ile Val Glu Val Leu Gly Ala Glu Thr Val Thr Ala Pro

120 125 130gtc gct gaa gcc tgg gat gct gtc tac tgg atc atg gca aat gtg ctg 547Val Ala Glu Ala Trp Asp Ala Val Tyr Trp Ile Met Ala Asn Val Leu

135 140 145atc ggt ttt gag aac aac ctt tat gct tcc aac gat ctg gag cct ggc 595Ile Gly Phe Glu Asn Asn Leu Tyr Ala Ser Asn Asp Leu Glu Pro Gly150155 160 165gac gtc ttc cgc gaa gtc acc gtg acc gcg aag aag cag ctc agc gca 643Asp Val Phe Arg Glu Val Thr Val Thr Ala Lys Lys Gln Leu Ser Ala

170 175 180acc gtc tgg gaa tac acc ctg gca ggt gag ctg gtt gcc cca gag cca 691Thr Val Trp Glu Tyr Thr Leu Ala Gly Glu Leu Val Ala Pro Glu Pro

185 190 195ggt cag tac acc tcc atc gga gta gtg ctt gac gac ggc gcc cgc cag 739Gly Gln Tyr Thr Ser Ile Gly Val Val Leu Asp Asp Gly Ala Arg Gln

200 205 210ctg cgc cag tac agc ttg ctc ggc ggc tcc gac acc gag tac cgc att 787Leu Arg Gln Tyr Ser Leu Leu Gly Gly Ser Asp Thr Glu Tyr Arg Ile

215 220 225gcg gtt gag gat aac ggc gag gtt tct gga ttc ctg cgt gat cgc gta 835Ala Val Glu Asp Asn Gly Glu Val Ser Gly Phe Leu Arg Asp Arg Val230 235 240 245tcc gtt ggt gac aag att gaa gcc acc atc gcg gcc ggc gac ctg gtt 883Ser Val Gly Asp Lys Ile Glu Ala Thr Ile Ala Ala Gly Asp Leu Val

250 255 260ctt aac aag gac acc aat cca gtt gtg ctg att tcc cag ggc atc ggc 931Leu Asn Lys Asp Thr Asn Pro Val Val Leu Ile Ser Gln Gly Ile Gly

265 270 275tcc acc cca atg gtg ggc atg ctc gca ggt atg aac cct gaa cgt gac 979Ser Thr Pro Met Val Gly Met Leu Ala Gly Met Asn Pro Glu Arg Asp

280 285 290gtt gtg gtt ttg cat gct gac cag gcc gag tcc acc tac gcg cag gtg 1027Val Val Val Leu His Ala Asp Gln Ala Glu Ser Thr Tyr Ala Gln Val

295 300 305gag gaa gtg cag ggg ctc gtc gaa aag ctc cct aag gct gcg ttt gaa 1075Glu Glu Val Gln Gly Leu Val Glu Lys Leu Pro Lys Ala Ala Phe Glu310 315 320 325atc ttc tac cgc gac aac gac cag tgg ctc gag gtc gct ggc cgc att 1123Ile Phe Tyr Arg Asp Asn Asp Gln Trp Leu Glu Val Ala Gly Arg Ile

330 335 340cca tca ggt gcg tcc gtg tac ctg tgc ggt ggc gtg gaa ttc ttg aag 1171Pro Ser Gly Ala Ser Val Tyr Leu Cys Gly Gly Val Glu Phe Leu Lys

345 350 355aac gtg cgt gag cag atc gag gcg ctc gat gag cag cct cgc gac gta 1219Asn Val Arg Glu Gln Ile Glu Ala Leu Asp Glu Gln Pro Arg Asp Val

360 365 370aac ttc gag ctc ttc gca cca aac gac tgg ctg att tcc taagcccaca 1268Asn Phe Glu Leu Phe Ala Pro Asn Asp Trp Leu Ile Ser

375380385 ccccagaact tcc 1281<210>790<211>386<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>790Leu Ile Val Ser Thr Gln Pro Ile Thr Asp Arg Ser Ala Leu Ser Ala 151015 Glu His Ala Glu Val Ile Lys Ala Thr Leu Pro Leu Val Gly Gly Lys

20 25 30Ile Asn Glu Ile Thr Pro Val Phe Tyr Asn Lys Met Phe Ala Ala His

35 40 45Pro Glu Leu Ile Ala Asn Thr Phe Asn Arg Gly Asn Gln Lys Gln Gly

50 55 60Asp Gln Gln Lys Ala Leu Ala Ala Ser Ile Ala Thr Phe Ala Thr Met 65 70 75 80Leu Val Thr Pro Asp Ala Pro Asp Pro Val Gln Leu Leu Ser Arg Ile

85 90 95Gly His Lys His Val Ser Leu Gly Ile Thr Ala Asp Gln Tyr Asp Ile

100 105 110Val His Glu His Leu Phe Ala Ala Ile Val Glu Val Leu Gly Ala Glu

115 120 125Thr Val Thr Ala Pro Val Ala Glu Ala Trp Asp Ala Val Tyr Trp Ile

130 135 140Met Ala Asn Val Leu Ile Gly Phe Glu Asn Asn Leu Tyr Ala Ser Asn145 150 155 160Asp Leu Glu Pro Gly Asp Val Phe Arg Glu Val Thr Val Thr Ala Lys

165 170 175Lys Gln Leu Ser Ala Thr Val Trp Glu Tyr Thr Leu Ala Gly Glu Leu

180 185 190Val Ala Pro Glu Pro Gly Gln Tyr Thr Ser Ile Gly Val Val Leu Asp

195 200 205Asp Gly Ala Arg Gln Leu Arg Gln Tyr Ser Leu Leu Gly Gly Ser Asp

210 215 220Thr Glu Tyr Arg Ile Ala Val Glu Asp Asn Gly Glu Val Ser Gly Phe225 230 235 240Leu Arg Asp Arg Val Ser Val Gly Asp Lys Ile Glu Ala Thr Ile Ala

245 250 255Ala Gly Asp Leu Val Leu Asn Lys Asp Thr Asn Pro Val Val Leu Ile

260 265 270Ser Gln Gly Ile Gly Ser Thr Pro Met Val Gly Met Leu Ala Gly Met

275 280 285Asn Pro Glu Arg Asp Val Val Val Leu His Ala Asp Gln Ala Glu Ser

290 295 300Thr Tyr Ala Gln Val Glu Glu Val Gln Gly Leu Val Glu Lys Leu Pro305 310 315 320Lys Ala Ala Phe Glu Ile Phe Tyr Arg Asp Asn Asp Gln Trp Leu Glu

325 330 335Val Ala Gly Arg Ile Pro Ser Gly Ala Ser Val Tyr Leu Cys Gly Gly

340 345 350Val Glu Phe Leu Lys Asn Val Arg Glu Gln Ile Glu Ala Leu Asp Glu

355 360 365Gln Pro Arg Asp Val Asn Phe Glu Leu Phe Ala Pro Asn Asp Trp Leu

370375380 Ile Ser385<210>791<211>990<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (967)<223>RXS02560<400>791ttggggcaag ccagctaacg catttcttgt ggaaaccgca gacattgagg ccgcccacgc 60ggaacttcta agagcagtgg aatgaaataa tccggtgctg atg cag ggc aac tcg 115

Met Gln Gly Asn Ser

1 5ctt aat ctg gca gac aac agc gag aga aag aag ccc atg ccg tca cca 163Leu Asn Leu Ala Asp Asn Ser Glu Arg Lys Lys Pro Met Pro Ser Pro

10 15 20gga gaa ctt tta gcc gcc cgc tac gga caa cct gca acc tgg acg cca 211Gly Glu Leu Leu Ala Ala Arg Tyr Gly Gln Pro Ala Thr Trp Thr Pro

25 30 35ccg cag tgg aat gag acg ctt gat gtc att cac cag cat cga tca gtt 259Pro Gln Trp Asn Glu Thr Leu Asp Val Ile His Gln His Arg Ser Val

40 45 50cgc agg tgg ttg gat aaa ccg gtt gat gat gac acc atc cgc acc att 307Arg Arg Trp Leu Asp Lys Pro Val Asp Asp Asp Thr Ile Arg Thr Ile

55 60 65att tcc gcc gca caa tcg gct gga acc tct tcc aat aag cag gtc att 355Ile Ser Ala Ala Gln Ser Ala Gly Thr Ser Ser Asn Lys Gln Val Ile 70 75 80 85tct gtc atc gtg gtt aaa gat cct gag ctg agg aaa ggc ctc gcg ggg 403Ser Val Ile Val Val Lys Asp Pro Glu Leu Arg Lys Gly Leu Ala Gly

90 95 100atc act cgc cag atg ttt ccg cac ctt gag cag gtt ccc gcg gtg ctg 451Ile Thr Arg Gln Met Phe Pro His Leu Glu Gln Val Pro Ala Val Leu

105 110 115att tgg ttg att gat tat tcc cga atc agt gcg gtg gca gcc aga gaa 499Ile Trp Leu Ile Asp Tyr Ser Arg Ile Ser Ala Val Ala Ala Arg Glu

120 125 130gat ctc cca aca ggg gct ctt gat tat ctc gat gag gcc gcg tgg ggg 547Asp Leu Pro Thr Gly Ala Leu Asp Tyr Leu Asp Glu Ala Ala Trp Gly

135 140 145ttc ctc gac gcc gga atc gca gct caa aac gct gca att gct gcg gag 595Phe Leu Asp Ala Gly Ile Ala Ala Gln Asn Ala Ala Ile Ala Ala Glu150 155 160 165tca ctt gga ttg gga acg ctc tat ttg ggt tcg gtg cgc aac gat gcg 643Ser Leu Gly Leu Gly Thr Leu Tyr Leu Gly Ser Val Arg Asn Asp Ala

170 175 180gaa gcc gtg cac aaa ttg ctt ggc ctt cca cct gag atc gtg cct gtc 691Glu Ala Val His Lys Leu Leu Gly Leu Pro Pro Glu Ile Val Pro Val

185 190 195gtg ggc ttg gaa atg ggg cat gcg gat ccg cct gaa cct gcc gga att 739Val Gly Leu Glu Met Gly His Ala Asp Pro Pro Glu Pro Ala Gly Ile

200 205 210aaa cct ccc ctg cca caa gaa gcc att gtt cac tgg gat acc tac acc 787Lys Pro Pro Leu Pro Gln Glu Ala Ile Val His Trp Asp Thr Tyr Thr

215 220225gag aaa aac ctc gaa ctt atc gat tcc tac gac cgc gcc ctc gac act 835Glu Lys Asn Leu Glu Leu Ile Asp Ser Tyr Asp Arg Ala Leu Asp Thr230 235 240 245tac tat tct cgc tac ggc cag cac cag ctc tgg tcg aag cag acg gcg 883Tyr Tyr Ser Arg Tyr Gly Gln His Gln Leu Trp Ser Lys Gln Thr Ala

250 255 260cat agg gcg gcg tcg aaa agc ttt tca aaa acc aac agg cag ttc ctt 931His Arg Ala Ala Ser Lys Ser Phe Ser Lys Thr Asn Arg Gln Phe Leu

265 270 275agg ggc gtg ttt gag cgc gcc ggg ttt ggg ctg aga taaaagcatg 977Arg Gly Val Phe Glu Arg Ala Gly Phe Gly Leu Arg

280285 attatggacg cct 990<210>792<211>289<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>792Met Gln Gly Asn Ser Leu Asn Leu Ala Asp Asn Ser Glu Arg Lys Lys 151015 Pro Met Pro Ser Pro Gly Glu Leu Leu Ala Ala Arg Tyr Gly Gln Pro

20 25 30Ala Thr Trp Thr Pro Pro Gln Trp Asn Glu Thr Leu Asp Val Ile His

35 40 45Gln His Arg Ser Val Arg Arg Trp Leu Asp Lys Pro Val Asp Asp Asp

50 55 60Thr Ile Arg Thr Ile Ile Ser Ala Ala Gln Ser Ala Gly Thr Ser Ser 65 70 75 80Asn Lys Gln Val Ile Ser Val Ile Val Val Lys Asp Pro Glu Leu Arg

85 90 95Lys Gly Leu Ala Gly Ile Thr Arg Gln Met Phe Pro His Leu Glu Gln

100 105 110Val Pro Ala Val Leu Ile Trp Leu Ile Asp Tyr Ser Arg Ile Ser Ala

115120 125Val Ala Ala Arg Glu Asp Leu Pro Thr Gly Ala Leu Asp Tyr Leu Asp

130 135 140Glu Ala Ala Trp Gly Phe Leu Asp Ala Gly Ile Ala Ala Gln Asn Ala145 150 155 160Ala Ile Ala Ala Glu Ser Leu Gly Leu Gly Thr Leu Tyr Leu Gly Ser

165 170 175Val Arg Asn Asp Ala Glu Ala Val His Lys Leu Leu Gly Leu Pro Pro

180 185 190Glu Ile Val Pro Val Val Gly Leu Glu Met Gly His Ala Asp Pro Pro

195 200 205Glu Pro Ala Gly Ile Lys Pro Pro Leu Pro Gln Glu Ala Ile Val His

210 215 220Trp Asp Thr Tyr Thr Glu Lys Asn Leu Glu Leu Ile Asp Ser Tyr Asp225 230 235 240Arg Ala Leu Asp Thr Tyr Tyr Ser Arg Tyr Gly Gln His Gln Leu Trp

245 250 255Ser Lys Gln Thr Ala His Arg Ala Ala Ser Lys Ser Phe Ser Lys Thr

260 265 270Asn Arg Gln Phe Leu Arg Gly Val Phe Glu Arg Ala Gly Phe Gly Leu

275280285 Arg<210>793<211>1425<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1402)<223>RXA00382<400>793aaaacactat tgaccacccc aatcgctgtt gagagtttgt aaagttcgac tgtcaacgag 60ctggattggc ttcacagatt gaattaatac aatgacgcac atg aca tcg tcc aat 115

Met Thr Ser Ser Asn

1 5acg gct cga tcc gca gag tgg ttt gaa aag gct cag aag ctc acc cct 163Thr Ala Arg Ser Ala Glu Trp Phe Glu Lys Ala Gln Lys Leu Thr Pro

10 15 20ggt ggt gtg aat tct cct gtt cgc gct ttc ggt tca gtt ggc gga caa 211Gly Gly Val Asn Ser Pro Val Arg Ala Phe Gly Ser Val Gly Gly Gln

25 30 35gcc cgt ttc atc gaa aaa gct cac ggt tca acg ctg atc gat gtg gac 259Ala Arg Phe Ile Glu Lys Ala His Gly Ser Thr Leu Ile Asp Val Asp

40 45 50gga aat gaa tac gtt gac ctg gtc tgt tct tgg ggc ccc atg ctg atg 307Gly Asn Glu Tyr Val Asp Leu Val Cys Ser Trp Gly Pro Met Leu Met

55 60 65ggt cac gct cac cca gca gtg gtc gag gct gtg cag aag gcc gtc gtg 355Gly His Ala His Pro Ala Val Val Glu Ala Val Gln Lys Ala Val Val 70 75 80 85gat ggt ctt tct ttc ggc gct ccc acc atc ggt gag gtt gag ttg gcc 403Asp Gly Leu Ser Phe Gly Ala Pro Thr Ile Gly Glu Val Glu Leu Ala

90 95 100caa gat atc gtc aag cgc act tct gtg gag gaa gtc cgc ctg gtc aac 451Gln Asp Ile Val Lys Arg Thr Ser Val Glu Glu Val Arg Leu Val Asn

105 110 115tcc ggc act gag gcc acc atg tcg gcg gtt cgt ctg gcg cgc ggt tac 499Ser Gly Thr Glu Ala Thr Met Ser Ala Val Arg Leu Ala Arg Gly Tyr

120 125 130act cag cgt tcc aag att ttg aag ttt gag ggc tgc tac cac ggc cac 547Thr Gln Arg Ser Lys Ile Leu Lys Phe Glu Gly Cys Tyr His Gly His

135 140 145gtc gat gcg ctg ctc gca tct gct ggt tct ggt gtc gca act ttc gct 595Val Asp Ala Leu Leu Ala Ser Ala Gly Ser GlyVal Ala Thr Phe Ala150 155 160 165ctg cct gat tcc cca ggc atc acc ggc gct cag act tct gac act att 643Leu Pro Asp Ser Pro Gly Ile Thr Gly Ala Gln Thr Ser Asp Thr Ile

170 175 180gtt gtt cct tac aac gac att gaa gcc gtg cgc aac gct ttt gcg gag 691Val Val Pro Tyr Asn Asp Ile Glu Ala Val Arg Asn Ala Phe Ala Glu

185 190 195tac cca ggc gag atc gcc tgc atc atc gca gag gca gcc ggt ggc aac 739Tyr Pro Gly Glu Ile Ala Cys Ile Ile Ala Glu Ala Ala Gly Gly Asn

200 205 210atg ggc acc gtc gct cca aag gac aac ttt aac gac aag ctt ctc gcg 787Met Gly Thr Val Ala Pro Lys Asp Asn Phe Asn Asp Lys Leu Leu Ala

215 220 225atc gct cac gct gac ggc gcg ctg ctg atc ctc gat gaa gtc atg acc 835Ile Ala His Ala Asp Gly Ala Leu Leu Ile Leu Asp Glu Val Met Thr230 235 240 245ggc ttc cgc acc tct tac cgt ggc tgg ttc ggc gta gac aag gtt gcc 883Gly Phe Arg Thr Ser Tyr Arg Gly Trp Phe Gly Val Asp Lys Val Ala

250 255 260gct gac ctg gtc acc ttc ggc aag gtc gtc tcc ggc ggc cta cct gcc 931Ala Asp Leu Val Thr Phe Gly Lys Val Val Ser Gly Gly Leu Pro Ala

265 270 275gca gcg ttt ggc ggc aag gct gaa atc atg aac atg ctg gcc cca cag 979Ala Ala Phe Gly Gly Lys Ala Glu Ile Met Asn Met Leu Ala Pro Gln

280 285 290ggc ccc gtc tac caa gca ggc aca ctg tcc ggc aac ccg gtt gcg gtc 1027Gly Pro Val Tyr Gln Ala Gly Thr Leu Ser Gly Asn Pro Val Ala Val

295 300305gca gct ggt cgg gca tcg ctt aag ctt gcc gac gaa tcc ctc tac aca 1075Ala Ala Gly Arg Ala Ser Leu Lys Leu Ala Asp Glu Ser Leu Tyr Thr310 315 320 325acc atc aac gcc aac gca gat cgt ctc cac ggt ttg atc tct gat gcc 1123Thr Ile Asn Ala Asn Ala Asp Arg Leu His Gly Leu Ile Ser Asp Ala

330 335 340tta acc cac gaa ggc gta gcc cac cac att cag cgt gcc tca aac atg 1171Leu Thr His Glu Gly Val Ala His His Ile Gln Arg Ala Ser Asn Met

345 350 355ctg tct atc cgt ttt gca gaa ggt gag ggc cac aac ttc tct gat atg 1219Leu Ser Ile Arg Phe Ala Glu Gly Glu Gly His Asn Phe Ser Asp Met

360 365 370aag gca gcc gac atc ttc cgc ttc gca ccg ttc ttc cac act ttg ctg 1267Lys Ala Ala Asp Ile Phe Arg Phe Ala Pro Phe Phe His Thr Leu Leu

375 380 385gac aac ggc gtc tac gca cca cca agc gtt ttc gaa acc tgg ttt gtg 1315Asp Asn Gly Val Tyr Ala Pro Pro Ser Val Phe Glu Thr Trp Phe Val390 395 400 405tct tcc gct ctc acg gac gat gat ttc tcc aag atc gag cag gca ctc 1363Ser Ser Ala Leu Thr Asp Asp Asp Phe Ser Lys Ile Glu Gln Ala Leu

410 415 420aag ccc gcc gca cgt gca gca gca gaa gcg aag gca tca tgacgcaaac 1412Lys Pro Ala Ala Arg Ala Ala Ala Glu Ala Lys Ala Ser

425430 cattgtccat cta 1425<5>794<211>434<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>794Met Thr Ser Ser Asn Thr Ala Arg Ser Ala Glu Trp Phe Glu Lys Ala 151015 Gln Lys Leu Thr Pro Gly Gly Val Asn Ser Pro Val Arg Ala Phe Gly

20 2530Ser Val Gly Gly Gln Ala Arg Phe Ile Glu Lys Ala His Gly Ser Thr

35 40 45Leu Ile Asp Val Asp Gly Asn Glu Tyr Val Asp Leu Val Cys Ser Trp

50 55 60Gly Pro Met Leu Met Gly His Ala His Pro Ala Val Val Glu Ala Val 65 70 75 80Gln Lys Ala Val Val Asp Gly Leu Ser Phe Gly Ala Pro Thr Ile Gly

85 90 95Glu Val Glu Leu Ala Gln Asp Ile Val Lys Arg Thr Ser Val Glu Glu

100 105 110Val Arg Leu Val Asn Ser Gly Thr Glu Ala Thr Met Ser Ala Val Arg

115 120 125Leu Ala Arg Gly Tyr Thr Gln Arg Ser Lys Ile Leu Lys Phe Glu Gly

130 135 140Cys Tyr His Gly His Val Asp Ala Leu Leu Ala Ser Ala Gly Ser Gly145 150 155 160Val Ala Thr Phe Ala Leu Pro Asp Ser Pro Gly Ile Thr Gly Ala Gln

165 170 175Thr Ser Asp Thr Ile Val Val Pro Tyr Asn Asp Ile Glu Ala Val Arg

180 185 190Asn Ala Phe Ala Glu Tyr Pro Gly Glu Ile Ala Cys Ile Ile Ala Glu

195 200 205Ala Ala Gly Gly Asn Met Gly Thr Val Ala Pro Lys Asp Asn Phe Asn

210 215 220Asp Lys Leu Leu Ala Ile Ala His Ala Asp Gly Ala Leu Leu Ile Leu225 230 235 240Asp Glu Val Met Thr Gly Phe Arg Thr Ser Tyr Arg Gly Trp Phe Gly

245250 255Val Asp Lys Val Ala Ala Asp Leu Val Thr Phe Gly Lys Val Val Ser

260 265 270Gly Gly Leu Pro Ala Ala Ala Phe Gly Gly Lys Ala Glu Ile Met Asn

275 280 285Met Leu Ala Pro Gln Gly Pro Val Tyr Gln Ala Gly Thr Leu Ser Gly

290 295 300Asn Pro Val Ala Val Ala Ala Gly Arg Ala Ser Leu Lys Leu Ala Asp305 310 315 320Glu Ser Leu Tyr Thr Thr Ile Asn Ala Asn Ala Asp Arg Leu His Gly

325 330 335Leu Ile Ser Asp Ala Leu Thr His Glu Gly Val Ala His His Ile Gln

340 345 350Arg Ala Ser Asn Met Leu Ser Ile Arg Phe Ala Glu Gly Glu Gly His

355 360 365Asn Phe Ser Asp Met Lys Ala Ala Asp Ile Phe Arg Phe Ala Pro Phe

370 375 380Phe His Thr Leu Leu Asp Asn Gly Val Tyr Ala Pro Pro Ser Val Phe385 390 395 400Glu Thr Trp Phe Val Ser Ser Ala Leu Thr Asp Asp Asp Phe Ser Lys

405 410 415Ile Glu Gln Ala Leu Lys Pro Ala Ala Arg Ala Ala Ala Glu Ala Lys

420425430 Ala Ser<210>795<211>1233<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1210)<223>RXA00156<400>795accgagagcg tggtacgcct catttagttt cctcctatga atcttgatgt ggttcatgcg 60tttttatgca atatcaacca aaagttggta cgatcctcat atg aat gaa cgc aca 115

Met Asn Glu Arg Thr

1 5tcg gat gca ttt gac gcc ctc ctt gtg ctc tcc ttc ggt ggt ccc gaa 163Ser Asp Ala Phe Asp Ala Leu Leu Val Leu Ser Phe Gly Gly Pro Glu

10 15 20ggg cac gag gag gtt cgt ccg ttt ttg gag aat gtc act cac gga agg 211Gly His Glu Glu Val Arg Pro Phe Leu Glu Asn Val Thr His Gly Arg

25 30 35ggg att ccg ccg gaa cgt cta gat gaa gtg gcg gtt cat tac cac cac 259Gly Ile Pro Pro Glu Arg Leu Asp Glu Val Ala Val His Tyr His His

40 45 50ttc ggt ggt atc agc ccc atc aat gcg ctg aac agg gaa att atc gcc 307Phe Gly Gly Ile Ser Pro Ile Asn Ala Leu Asn Arg Glu Ile Ile Ala

55 60 65aat gtg gaa aaa gaa ttg gcg tct cgc gat cac aag ctg cct gtt tat 355Asn Val Glu Lys Glu Leu Ala Ser Arg Asp His Lys Leu Pro Val Tyr 70 75 80 85ttt ggt aac cgc aac tgg aag ccg ttt gat aat gag gcc gct gaa caa 403Phe Gly Asn Arg Asn Trp Lys Pro Phe Asp Asn Glu Ala Ala Glu Gln

90 95 100atg gct gat gac ggc gtg aaa aac gcg ctg gtg ttg gca act tcc gct 451Met Ala Asp Asp Gly Val Lys Asn Ala Leu Val Leu Ala Thr Ser Ala

105 110 115tgg ggt ggc tac tcc ggt tgt cgg cag tac cag gaa gat att cag ggc 499Trp Gly Gly Tyr Ser Gly Cys Arg Gln Tyr Gln Glu Asp Ile Gln Gly

120 125 130atg atc aag cac ctg gag tct cag ggg cag tcg atc acg ttc acc aag 547Met Ile Lys His Leu Glu Ser Gln Gly Gln Ser Ile Thr Phe Thr Lys

135140 145ctg cgt cag ttc tac gat cac cct cgt ttt gtc tcc acc atg gct caa 595Leu Arg Gln Phe Tyr Asp His Pro Arg Phe Val Ser Thr Met Ala Gln150 155 160 165ttg gtt cag gat tcc tac gcg aag ctt ccc gat gag ctg cga gat gag 643Leu Val Gln Asp Ser Tyr Ala Lys Leu Pro Asp Glu Leu Arg Asp Glu

170 175 180gcg cgt ctg gtc ttc acc gcg cac tcc att cca ctg act gcg gac aat 691Ala Arg Leu Val Phe Thr Ala His Ser Ile Pro Leu Thr Ala Asp Asn

185 190 195gct gcg gga acc cct gag gat ggc tcc ttg tat tcc aca cag gtc aag 739Ala Ala Gly Thr Pro Glu Asp Gly Ser Leu Tyr Ser Thr Gln Val Lys

200 205 210gaa gcg tca gca ctg att gct gag gct gtt ggt gtg tca gat ttt gat 787Glu Ala Ser Ala Leu Ile Ala Glu Ala Val Gly Val Ser Asp Phe Asp

215 220 225gtg gtg tgg cag tcc cgc tcg ggt agc ccg cac act ccg tgg ctg gag 835Val Val Trp Gln Ser Arg Ser Gly Ser Pro His Thr Pro Trp Leu Glu230 235 240 245cct gac atc gtg gat cac gca gtg gag ctc aac gag aag ggt caa aaa 883Pro Asp Ile Val Asp His Ala Val Glu Leu Asn Glu Lys Gly Gln Lys

250 255 260gcg ctc gtt gtc tgc cct gta ggc ttt att tct gat cat atg gaa gtc 931Ala Leu Val Val Cys Pro Val Gly Phe Ile Ser Asp His Met Glu Val

265 270 275att tgg gat ctt gat tcc gag ctg atg gaa gaa gcc gag aag cgc aac 979Ile Trp Asp Leu Asp Ser Glu Leu Met Glu Glu Ala Glu Lys Arg Asn

280 285 290atg gtg gtc gag cgt gtc gct acc gtt ggc ccc acc gat gaa ttc gca 1027Met Val Val Glu Arg Val Ala Thr Val Gly Pro Thr Asp Glu Phe Ala

295 300 305gcc ctt gtg gtt gat ctc atc gag gag gca gag ctc aag cgc gtt atc 1075Ala Leu Val Val Asp Leu Ile Glu Glu Ala Glu Leu Lys Arg Val Ile310 315 320 325gag cgc ctt gga aag ctg cca gca cgc gga agt tcc gtc aac ggc gca 1123Glu Arg Leu Gly Lys Leu Pro Ala Arg Gly Ser Ser Val Asn Gly Ala

330 335 340ccg tgt ggc gac ggc tgc tgt ggt acc gcc aag cat aaa acc gcg cgg 1171Pro Cys Gly Asp Gly Cys Cys Gly Thr Ala Lys His Lys Thr Ala Arg

345 350 355gtg aac ccc aac gct cgc tca gcg gcg cca gct gcc aac taggagtgat 1220Val Asn Pro Asn Ala Arg Ser Ala Ala Pro Ala Ala Asn

360365370 agtccctcgc aaa 1233<210>796<211>370<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>796Met Asn Glu Arg Thr Ser Asp Ala Phe Asp Ala Leu Leu Val Leu Ser 151015 Phe Gly Gly Pro Glu Gly His Glu Glu Val Arg Pro Phe Leu Glu Asn

20 25 30Val Thr His Gly Arg Gly Ile Pro Pro Glu Arg Leu Asp Glu Val Ala

35 40 45Val His Tyr His His Phe Gly Gly Ile Ser Pro Ile Asn Ala Leu Asn

50 55 60Arg Glu Ile Ile Ala Asn Val Glu Lys Glu Leu Ala Ser Arg Asp His 65 70 75 80Lys Leu Pro Val Tyr Phe Gly Asn Arg Asn Trp Lys Pro Phe Asp Asn

85 90 95Glu Ala Ala Glu Gln Met Ala Asp Asp Gly Val Lys Asn Ala Leu Val

100 105 110Leu Ala Thr Ser Ala Trp Gly Gly Tyr Ser Gly Cys Arg Gln Tyr Gln

115 120 125Glu Asp Ile Gln Gly Met Ile Lys His Leu Glu Ser Gln Gly Gln Ser

130 135 140Ile Thr Phe Thr Lys Leu Arg Gln Phe Tyr Asp His Pro Arg Phe Val145 150 155 160Ser Thr Met Ala Gln Leu Val Gln Asp Ser Tyr Ala Lys Leu Pro Asp

165 170 175Glu Leu Arg Asp Glu Ala Arg Leu Val Phe Thr Ala His Ser Ile Pro

180 185 190Leu Thr Ala Asp Asn Ala Ala Gly Thr Pro Glu Asp Gly Ser Leu Tyr

195 200 205Ser Thr Gln Val Lys Glu Ala Ser Ala Leu Ile Ala Glu Ala Val Gly

210 215 220Val Ser Asp Phe Asp Val Val Trp Gln Ser Arg Ser Gly Ser Pro His225 230 235 240Thr Pro Trp Leu Glu Pro Asp Ile Val Asp His Ala Val Glu Leu Asn

245 250 255Glu Lys Gly Gln Lys Ala Leu Val Val Cys Pro Val Gly Phe Ile Ser

260 265 270Asp His Met Glu Val Ile Trp Asp Leu Asp Ser Glu Leu Met Glu Glu

275 280 285Ala Glu Lys Arg Asn Met Val Val Glu Arg Val Ala Thr Val Gly Pro

290 295 300Thr Asp Glu Phe Ala Ala Leu Val Val Asp Leu Ile Glu Glu Ala Glu305 310 315 320Leu Lys Arg Val Ile Glu Arg Leu Gly Lys Leu Pro Ala Arg Gly Ser

325 330 335Ser Val Asn Gly Ala Pro Cys Gly Asp Gly Cys Cys Gly Thr Ala Lys

340 345 350His Lys Thr Ala Arg Val Asn Pro Asn Ala Arg Ser Ala Ala Pro Ala

355 360 365Ala Asn

370<210>797<211>810<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (787)<223>RXA00624<400>797tccatgacgt tttgaatgga aaatctccat ttgtggagtt agaagaagac cactagtttt 60caacaggacg acaacggccg gacatgcgac aatacaatgc atg tcc ggc cgt ctt 115

Met Ser Gly Arg Leu

1 5ctt gtt tca gtt tct agt att ttc gac cag acc cga tcg gcg gct gac 163Leu Val Ser Val Ser Ser Ile Phe Asp Gln Thr Arg Ser Ala Ala Asp

10 15 20agg ctc att tca gac ctg cga gcc gac ggc atc gag gtc tca tta ctt 211Arg Leu Ile Ser Asp Leu Arg Ala Asp Gly Ile Glu Val Ser Leu Leu

25 30 35gtc gca ccc cgc atc gat ggg gac tgg cgt ctc gcc aaa gac aaa ggg 259Val Ala Pro Arg Ile Asp Gly Asp Trp Arg Leu Ala Lys Asp Lys Gly

40 45 50acc ctc gcg tgg atg gaa caa caa cgc gaa cgc ggc cac gaa ctc atc 307Thr Leu Ala Trp Met Glu Gln Gln Arg Glu Arg Gly His Glu Leu Ile

55 60 65ctc aac ggt ttc gac caa gca gtt cag gga cgt cgc tca gaa ttc gcc 355Leu Asn Gly Phe Asp Gln Ala Val Gln Gly Arg Arg Ser Glu Phe Ala 70 75 80 85aac ctt gaa cgg cac gaa gca cgt ctt cgc ctt acc ggt gcc att agg 403Asn Leu Glu Arg His Glu Ala Arg Leu Arg Leu Thr Gly Ala Ile Arg

90 95 100caa atg cag aaa att ggc ttc gaa ttc caa atc ttt gcc cca cct cgt 451Gln Met Gln Lys Ile Gly Phe Glu Phe Gln Ile Phe Ala Pro Pro Arg

105 110 115tgg aga atg tca gaa ggc acc ttc gcg gta ctc cca gaa ttt gat ttc 499Trp Arg Met Ser Glu Gly Thr Phe Ala Val Leu Pro Glu Phe Asp Phe

120 125 130aac gtc gcc gcc tcg acc agg gga tta cat aac ctc gac acc ggc gaa 547Asn Val Ala Ala Ser Thr Arg Gly Leu His Asn Leu Asp Thr Gly Glu

135 140 145ttc ttg gcg tgt aga aac ctc tcc gtg ggt gaa ggt ttt ggt gct gca 595Phe Leu Ala Cys Arg Asn Leu Ser Val Gly Glu Gly Phe Gly Ala Ala150 155 160 165aaa tgg tgg cgc aag aat gtc atc aag gct gtc act cgt gga gcg gaa 643Lys Trp Trp Arg Lys Asn Val Ile Lys Ala Val Thr Arg Gly Ala Glu

170 175 180aaa gga aat aca gtg cgc ttg tcc gca tcg gcg cga aat ctc acc aac 691Lys Gly Asn Thr Val Arg Leu Ser Ala Ser Ala Arg Asn Leu Thr Asn

185 190 195cct aaa gtc gca gct gac ttc cgg gaa gct gca tta gct gcc ttg gat 739Pro Lys Val Ala Ala Asp Phe Arg Glu Ala Ala Leu Ala Ala Leu Asp

200 205 210ttg ggt gct cag gtg caa acc tat tct cag gcg gcc gca caa ctg gcc 787Leu Gly Ala Gln Val Gln Thr Tyr Ser Gln Ala Ala Ala Gln Leu Ala

215220225 tagttgggga ggttcggggc acc 810<810>798<211>229<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>798Met Ser Gly Arg Leu Leu Val Ser Val Ser Ser Ile Phe Asp Gln Thr 151015 Arg Ser Ala Ala Asp Arg Leu Ile Ser Asp Leu Arg Ala Asp Gly Ile

20 25 30Glu Val Ser Leu Leu Val Ala Pro Arg Ile Asp Gly Asp Trp Arg Leu

35 40 45Ala Lys Asp Lys Gly Thr Leu Ala Trp Met Glu Gln Gln Arg Glu Arg

50 55 60Gly His Glu Leu Ile Leu Asn Gly Phe Asp Gln Ala Val Gln Gly Arg 65 70 75 80Arg Ser Glu Phe Ala Asn Leu Glu Arg His Glu Ala Arg Leu Arg Leu

85 90 95Thr Gly Ala Ile Arg Gln Met Gln Lys Ile Gly Phe Glu Phe Gln Ile

100 105 110Phe Ala Pro Pro Arg Trp Arg Met Ser Glu Gly Thr Phe Ala Val Leu

115 120 125Pro Glu Phe Asp Phe Asn Val Ala Ala Ser Thr Arg Gly Leu His Asn

130 135 140Leu Asp Thr Gly Glu Phe Leu Ala Cys Arg Asn Leu Ser Val Gly Glu145 150 155 160Gly Phe Gly Ala Ala Lys Trp Trp Arg Lys Asn Val Ile Lys Ala Val

165 170 175Thr Arg Gly Ala Glu Lys Gly Asn Thr Val Arg Leu Ser Ala Ser Ala

180 185 190Arg Asn Leu Thr Asn Pro Lys Val Ala Ala Asp Phe Arg Glu Ala Ala

195 200 205Leu Ala Ala Leu Asp Leu Gly Ala Gln Val Gln Thr Tyr Ser Gln Ala

210215220 Ala Ala Gln Leu Ala225<210>799<211>956<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1).<933)<223>RXA00306<400>799gat tcc ggc att ccc acg cag ttg gtg gag ggc agc tgg ttt gaa ccg 48Asp Ser Gly Ile Pro Thr Gln Leu Val Glu Gly Ser Trp Phe Glu Pro 151015 gtt cgc ggg cgc acc ttt gac cgc atc atc gcc aac ccg ccg ttc gtg 96Val Arg Gly Arg Thr Phe Asp Arg Ile Ile Ala Asn Pro Pro Phe Val<2>DNA<213>(Corynebacterium glutamicum)<220><CDS<222>(1).<933)<223><60><2>DNA<400><2>DNA<2><2

20 25 30gtg gga cca ccg gaa att ggg cat gtg tac cgc gat tcc ggc atg gat 144Val Gly Pro Pro Glu Ile Gly His Val Tyr Arg Asp Ser Gly Met Asp

35 40 45cta gac ggc gcg acc gcg ttg gtg gtc aaa gaa gcc tgc gcg cat ctc 192Leu Asp Gly Ala Thr Ala Leu Val Val Lys Glu Ala Cys Ala His Leu

50 55 60aac cct ggt ggc acc gct cac ctg ctc ggc gca tgg gtg cat tcc gcg 240Asn Pro Gly Gly Thr Ala His Leu Leu Gly Ala Trp Val His Ser Ala 65 70 75 80gat caa tcg tgg cag cag cgc gtt gca gaa tgg ttg ccg gat aac ggt 288Asp Gln Ser Trp Gln Gln Arg Val Ala Glu Trp Leu Pro Asp Asn Gly

85 90 95tat gtt gct tgg gtt att gag cgc gac gcc gtg agc ccc gcg cag tat 336Tyr Val Ala Trp Val Ile Glu Arg Asp Ala Val Ser Pro Ala Gln Tyr

100 105 110gtg ggc acg tgg ctt agt gat gag tcc ctc gat ctg cgt agc ccc gag 384Val Gly Thr Trp Leu Ser Asp Glu Ser Leu Asp Leu Arg Ser Pro Glu

115 120 125gca gca gca cgc acc accgcg tgg ctt aac cac ttt gaa aaa gcc aag 432Ala Ala Ala Arg Thr Thr Ala Trp Leu Asn His Phe Glu Lys Ala Lys

130 135 140gtt caa ggc gtt ggt ttt ggt ttc atc gcc atc caa cgt ctg gag gaa 480Val Gln Gly Val Gly Phe Gly Phe Ile Ala Ile Gln Arg Leu Glu Glu145 150 155 160gac gag gcg gat gag aaa tcc gat atc ttg gct gaa tcc atg acc cag 528Asp Glu Ala Asp Glu Lys Ser Asp Ile Leu Ala Glu Ser Met Thr Gln

165 170 175tac ttc gag gat cct ctc ggc cct gaa att gag gag tac ttc acc cgc 576Tyr Phe Glu Asp Pro Leu Gly Pro Glu Ile Glu Glu Tyr Phe Thr Arg

180 185 190acc gca tgg ctt cgt gaa caa act cgc gat tcc att ctg agc tcc cgc 624Thr Ala Trp Leu Arg Glu Gln Thr Arg Asp Ser Ile Leu Ser Ser Arg

195 200 205ttc aaa gtt cgc cct ggc gtg gcc cgg gaa caa atc agc ctg gcc gat 672Phe Lys Val Arg Pro Gly Val Ala Arg Glu Gln Ile Ser Leu Ala Asp

210 215 220gcg gaa gaa ggc atg ggc ttt agt cct gtc acg ttg agg ctc acc cgc 720Ala Glu Glu Gly Met Gly Phe Ser Pro Val Thr Leu Arg Leu Thr Arg225 230 235 240acc gat ggt cct cgt tgg tcc cat gat gtt gat gag cat gtg gct tcc 768Thr Asp Gly Pro Arg Trp Ser His Asp Val Asp Glu His Val Ala Ser

245 250 255atc gtc gca gga ctt aac cca cat gga ctc ccc ttt gaa gaa atc ctg 816Ile Val Ala Gly Leu Asn Pro His Gly Leu Pro Phe Glu Glu Ile Leu

260 265 270gaa atg tac gcg atg gct caa ggt atc gag gga gaa tcc ctg cac aac 864Glu Met Tyr Ala Met Ala Gln Gly Ile Glu Gly Glu SerLeu His Asn

275 280 285ggc gcc att gcg gcg ttg gtg gat ctc atc cgc cac gga ttg gtg ttg 912Gly Ala Ile Ala Ala Leu Val Asp Leu Ile Arg His Gly Leu Val Leu

290295300 ccc gct gat ctt ctc gat tct taaataagga ctgattgtga aag 956Pro Ala Asp Leu Leu Asp Ser 305310<210>800<211>311<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>800Asp Ser Gly Ile Pro Thr Gln Leu Val Glu Gly Ser Trp Phe Glu Pro 151015 Val Arg Gly Arg Thr Phe Asp Arg Ile Ile Ala Asn Pro Pro Phe Val

20 25 30Val Gly Pro Pro Glu Ile Gly His Val Tyr Arg Asp Ser Gly Met Asp

35 40 45Leu Asp Gly Ala Thr Ala Leu Val Val Lys Glu Ala Cys Ala His Leu

50 55 60Asn Pro Gly Gly Thr Ala His Leu Leu Gly Ala Trp Val His Ser Ala 65 70 75 80Asp Gln Ser Trp Gln Gln Arg Val Ala Glu Trp Leu Pro Asp Asn Gly

85 90 95Tyr Val Ala Trp Val Ile Glu Arg Asp Ala Val Ser Pro Ala Gln Tyr

100 105 110Val Gly Thr Trp Leu Ser Asp Glu Ser Leu Asp Leu Arg Ser Pro Glu

115 120 125Ala Ala Ala Arg Thr Thr Ala Trp Leu Asn His Phe Glu Lys Ala Lys

130 135 140Val Gln Gly Val Gly Phe Gly Phe Ile Ala Ile Gln Arg Leu Glu Glu145 150 155 160Asp Glu Ala Asp Glu Lys Ser Asp Ile Leu Ala Glu Ser Met Thr Gln

165 170 175Tyr Phe Glu Asp Pro Leu Gly Pro Glu Ile Glu Glu Tyr Phe Thr Arg

180 185 190Thr Ala Trp Leu Arg Glu Gln Thr Arg Asp Ser Ile Leu Ser Ser Arg

195 200 205Phe Lys Val Arg Pro Gly Val Ala Arg Glu Gln Ile Ser Leu Ala Asp

210 215 220Ala Glu Glu Gly Met Gly Phe Ser Pro Val Thr Leu Arg Leu Thr Arg225 230 235 240Thr Asp Gly Pro Arg Trp Ser His Asp Val Asp Glu His Val Ala Ser

245 250 255Ile Val Ala Gly Leu Asn Pro His Gly Leu Pro Phe Glu Glu Ile Leu

260 265 270Glu Met Tyr Ala Met Ala Gln Gly Ile Glu Gly Glu Ser Leu His Asn

275 280 285Gly Ala Ile Ala Ala Leu Val Asp Leu Ile Arg His Gly Leu Val Leu

290295300 Pro Ala Asp Leu Leu Asp Ser 305310<210>801<211>1263<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<1240>RXA00884<400>801catcttccgt ttcataccct gcactctacc ctgttcttag gaattcgcta tgtttaacat 60caattaatca tgtatagggg gcaggcacta ggcttggggc atg tca gtt ttt ggt 115

Met Ser Val Phe Gly

1 5gtg tat att cat gtg ccg ttt tgt tca act cgg tgc ggt tat tgc gat 163Val Tyr Ile His Val Pro Phe Cys Ser Thr Arg Cys Gly Tyr Cys Asp

10 15 20ttc aac acc tat act gct ggg gaa tta ggt agt act gca ggc ccg gac 211Phe Asn Thr Tyr Thr Ala Gly Glu LeuGly Ser Thr Ala Gly Pro Asp

25 30 35acc tat ctt gac tcg ttg gaa gtt gag ttg gag atg gct gtg gct tcg 259Thr Tyr Leu Asp Ser Leu Glu Val Glu Leu Glu Met Ala Val Ala Ser

40 45 50ctg gat aat cct cgg cag gcg gaa act atc ttt att ggc ggg ggt acc 307Leu Asp Asn Pro Arg Gln Ala Glu Thr Ile Phe Ile Gly Gly Gly Thr

55 60 65ccg tcg ttg att ggt gcg gac ggt ttg gcc agg gtt ttg ggg gct gtg 355Pro Ser Leu Ile Gly Ala Asp Gly Leu Ala Arg Val Leu Gly Ala Val 70 75 80 85cgc aat act ttt ggc att gcg gat ggt gcg gaa gtc acc acg gag tcc 403Arg Asn Thr Phe Gly Ile Ala Asp Gly Ala Glu Val Thr Thr Glu Ser

90 95 100aat ccg gag tct acc tcg cct gag ttt ttt gat ggc ctg cgt gag gcg 451Asn Pro Glu Ser Thr Ser Pro Glu Phe Phe Asp Gly Leu Arg Glu Ala

105 110 115ggc tac aac agg att tcg tta ggg atg cag tcg gcg tcg tca agc gtt 499Gly Tyr Asn Arg Ile Ser Leu Gly Met Gln Ser Ala Ser Ser Ser Val

120 125 130ttg aag gtg ctg gac cgc acg cac acc cca ggg cgc ccg gtg gcg gcg 547Leu Lys Val Leu Asp Arg Thr His Thr Pro Gly Arg Pro Val Ala Ala

135 140 145gcc aag gag gca cgt gag gcg ggg ttt gag cat gtc aat ttg gac atg 595Ala Lys Glu Ala Arg Glu Ala Gly Phe Glu His Val Asn Leu Asp Met150 155 160 165att tat ggc acg ccg aca gag acc gat gat gat gtc cgc aag acg ctg 643Ile Tyr Gly Thr Pro Thr Glu Thr Asp Asp Asp Val Arg Lys Thr Leu

170 175180aat gcg gtg ctc gaa gcg aac gtg gat cac gtg tct gcc tat tcc ttg 691Asn Ala Val Leu Glu Ala Asn Val Asp His Val Ser Ala Tyr Ser Leu

185 190 195atc gtg aaa gat ggc acg gcg atg gcg cgc aag gtg cac aag ggc gag 739Ile Val Lys Asp Gly Thr Ala Met Ala Arg Lys Val His Lys Gly Glu

200 205 210ctg cca gcg ccg gac gag gat gtc tac gct gat cgt ttt gag ctt atc 787Leu Pro Ala Pro Asp Glu Asp Val Tyr Ala Asp Arg Phe Glu Leu Ile

215 220 225gac gct cgc ctg cgc tca gct ggt ttc gat tgg tac gag gtg tcc aac 835Asp Ala Arg Leu Arg Ser Ala Gly Phe Asp Trp Tyr Glu Val Ser Asn230 235 240 245tgg gcg aaa ccc ggc gga gaa tgc aag cac aac atg ggc tat tgg gtc 883Trp Ala Lys Pro Gly Gly Glu Cys Lys His Asn Met Gly Tyr Trp Val

250 255 260gac ggc gac tgg tgg ggc gcg ggc ccg ggc gcg cac tcg cac atc ggc 931Asp Gly Asp Trp Trp Gly Ala Gly Pro Gly Ala His Ser His Ile Gly

265 270 275gac cgc cgc ttc tac aac atc aag cac cca gcg cgt tac tcc gcg cag 979Asp Arg Arg Phe Tyr Asn Ile Lys His Pro Ala Arg Tyr Ser Ala Gln

280 285 290att gcg gcc ggc gag ctg ccc att aag gaa aca gag cgg ctg acg gcg 1027Ile Ala Ala Gly Glu Leu Pro Ile Lys Glu Thr Glu Arg Leu Thr Ala

295 300 305gaa gat cac cac acc gag cgc gtc atg ctt ggt ttg cgc ctg aaa caa 1075Glu Asp His His Thr Glu Arg Val Met Leu Gly Leu Arg Leu Lys Gln310 315 320 325ggc gtg ccg ctg aac ctt ttc gca ccc gca gcg cgc ccg gtc atc gac 1123Gly Val Pro Leu Asn Leu Phe Ala Pro Ala Ala Arg Pro Val Ile Asp

330 335 340cgt cat atc gca ggg ggc ctg ctg cac gtc aat gcg ctg ggc aac ctg 1171Arg His Ile Ala Gly Gly Leu Leu His Val Asn Ala Leu Gly Asn Leu

345 350 355gcg gtg acc gat gcg gga cgt ttg ctt gcc gac ggc atc atc gcc gac 1219Ala Val Thr Asp Ala Gly Arg Leu Leu Ala Asp Gly Ile Ile Ala Asp

360 365 370att ttg ctt agt gaa gaa gac taaatattta gtagggttac aga 1263Ile Leu Leu Ser Glu Glu Asp

375380<210>802<211>380<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>802Met Ser Val Phe Gly Val Tyr Ile His Val Pro Phe Cys Ser Thr Arg 151015 Cys Gly Tyr Cys Asp Phe Asn Thr Tyr Thr Ala Gly Glu Leu Gly Ser

20 25 30Thr Ala Gly Pro Asp Thr Tyr Leu Asp Ser Leu Glu Val Glu Leu Glu

35 40 45Met Ala Val Ala Ser Leu Asp Asn Pro Arg Gln Ala Glu Thr Ile Phe

50 55 60Ile Gly Gly Gly Thr Pro Ser Leu Ile Gly Ala Asp Gly Leu Ala Arg 65 70 75 80Val Leu Gly Ala Val Arg Asn Thr Phe Gly Ile Ala Asp Gly Ala Glu

85 90 95Val Thr Thr Glu Ser Asn Pro Glu Ser Thr Ser Pro Glu Phe Phe Asp

100 105 110Gly Leu Arg Glu Ala Gly Tyr Asn Arg Ile Ser Leu Gly Met Gln Ser

115 120 125Ala Ser Ser Ser Val Leu Lys Val Leu Asp Arg Thr His Thr Pro Gly

130 135 140Arg Pro Val Ala Ala Ala Lys Glu Ala Arg Glu Ala Gly Phe Glu His145 150 155 160Val Asn Leu Asp Met Ile Tyr Gly Thr Pro Thr Glu Thr Asp Asp Asp

165 170 175Val Arg Lys Thr Leu Asn Ala Val Leu Glu Ala Asn Val Asp His Val

180 185 190Ser Ala Tyr Ser Leu Ile Val Lys Asp Gly Thr Ala Met Ala Arg Lys

195 200 205Val His Lys Gly Glu Leu Pro Ala Pro Asp Glu Asp Val Tyr Ala Asp

210 215 220Arg Phe Glu Leu Ile Asp Ala Arg Leu Arg Ser Ala Gly Phe Asp Trp225 230 235 240Tyr Glu Val Ser Asn Trp Ala Lys Pro Gly Gly Glu Cys Lys His Asn

245 250 255Met Gly Tyr Trp Val Asp Gly Asp Trp Trp Gly Ala Gly Pro Gly Ala

260 265 270His Ser His Ile Gly Asp Arg Arg Phe Tyr Asn Ile Lys His Pro Ala

275 280 285Arg Tyr Ser Ala Gln Ile Ala Ala Gly Glu Leu Pro Ile Lys Glu Thr

290 295 300Glu Arg Leu Thr Ala Glu Asp His His Thr Glu Arg Val Met Leu Gly305 310 315 320Leu Arg Leu Lys Gln Gly Val Pro Leu Asn Leu Phe Ala Pro Ala Ala

325 330 335Arg Pro Val Ile Asp Arg His Ile Ala Gly Gly Leu Leu His Val Asn

340 345 350Ala Leu Gly Asn Leu Ala Val Thr Asp Ala Gly Arg Leu Leu Ala Asp

355 360 365Gly Ile Ile Ala Asp Ile Leu Leu Ser Glu Glu Asp

370375380<210>803<211>522<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (499)<223>RXN02503<400>803gcagcaccgg caaccacgtc cgtcaacgcg tcagaactgc cggatgcggg tatcgtcgca 60ttcgtgaacg caccttctgc cacacaaacg agggagtaac atg acc tta aaa att 115

Met Thr Leu Lys Ile

1 5ggt acc cga gga tcc aaa ctt gcc acc acc caa gct ggc acc atc cgc 163Gly Thr Arg Gly Ser Lys Leu Ala Thr Thr Gln Ala Gly Thr Ile Arg

10 15 20gac cag ctg aaa cac tac gga cgc gac gct gaa ctg cac atc gtg acc 211Asp Gln Leu Lys His Tyr Gly Arg Asp Ala Glu Leu His Ile Val Thr

25 30 35acc cct ggt gat gtc aac atg tcc cca gtc gag cgt atc ggc gtc ggc 259Thr Pro Gly Asp Val Asn Met Ser Pro Val Glu Arg Ile Gly Val Gly

40 45 50gtg ttc acc cag gcg ctg cgc gat gtg ttg cat tcc ggt gaa tgc gat 307Val Phe Thr Gln Ala Leu Arg Asp Val Leu His Ser Gly Glu Cys Asp

55 60 65gtg gct gtg cac tcc atg aag gat ctg ccg acc gcc acc gat cct cga 355Val Ala Val His Ser Met Lys Asp Leu Pro Thr Ala Thr Asp Pro Arg 70 75 80 85ttc cac ctg gtc gtg cca act cgt gcg gac tcg cgc gag gcc ctt atc 403Phe His Leu Val Val Pro Thr Arg Ala Asp Ser Arg Glu Ala Leu Ile

90 95 100gcc cgc gac ggc ctg actctg gct gag ctt cca gaa agg cgc aaa ggt 451Ala Arg Asp Gly Leu Thr Leu Ala Glu Leu Pro Glu Arg Arg Lys Gly

105 110 115ggg aac ttc cgc tcc tcg acg cat ctc cca gct caa ggc aat ccg ccc 499Gly Asn Phe Arg Ser Ser Thr His Leu Pro Ala Gln Gly Asn Pro Pro

120125130 tgacctggag attctcccac tgc 522<210>804<211>133<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>804Met Thr Leu Lys Ile Gly Thr Arg Gly Ser Lys Leu Ala Thr Thr Gln 151015 Ala Gly Thr Ile Arg Asp Gln Leu Lys His Tyr Gly Arg Asp Ala Glu

20 25 30Leu His Ile Val Thr Thr Pro Gly Asp Val Asn Met Ser Pro Val Glu

35 40 45Arg Ile Gly Val Gly Val Phe Thr Gln Ala Leu Arg Asp Val Leu His

50 55 60Ser Gly Glu Cys Asp Val Ala Val His Ser Met Lys Asp Leu Pro Thr 65 70 75 80Ala Thr Asp Pro Arg Phe His Leu Val Val Pro Thr Arg Ala Asp Ser

85 90 95Arg Glu Ala Leu Ile Ala Arg Asp Gly Leu Thr Leu Ala Glu Leu Pro

100 105 110Glu Arg Arg Lys Gly Gly Asn Phe Arg Ser Ser Thr His Leu Pro Ala

115 120 125Gln Gly Asn Pro Pro

130<210>805<211>558<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) · (535)<223>FRXA02503<220><221>misc _ feature<222>409, 421<223>n<a, c, t, or g<220><221>VARIANT<222>96<223>Xaa<Ser<220><221>VARIANT<222>99<223>Xaa Gly<220><221>VARIANT<222>106<223>Ala<220><221>VARIANT<222>107<223>Xaa<220>Asp<220>va<221>va<222>ant<222>107<223>Xaa<220>va<222>ant<222>Leu<220>Xaa<220>va<221>va<222>ant<222>Leu<220>va<221>va<220>ant<220>va<222>ant<223>Leu<220>ant<220>Leu<16>ant<220>Leu<16>Leu<220>Leu<16>ant<16>Leu<220>Leu<16>Leu<14>ant<14>Leu<16>Leu<220 cacacaaacg agggagtaac atg acc tta aaa att 115

Met Thr Leu Lys Ile

1 5ggt acc cga gga tcc aaa ctt gcc acc acc caa gct ggc acc atc cgc 163Gly Thr Arg Gly Ser Lys Leu Ala Thr Thr Gln Ala Gly Thr Ile Arg

10 15 20gac cag ctg aaa cac tac gga cgc gac gct gaa ctg cac atc gtg acc 211Asp Gln Leu Lys His Tyr Gly Arg Asp Ala Glu Leu His Ile Val Thr

25 30 35acc cct ggt gat gtc aac atg tcc cca gtc gag cgt atc ggc gtc ggc 259Thr Pro Gly Asp Val Asn Met Ser Pro Val Glu Arg Ile Gly Val Gly

40 45 50gtg ttc acc cag gcg ctg cgc gat gtg ttg cat tcc ggt gaa tgc gat 307Val Phe Thr Gln Ala Leu Arg Asp Val Leu His Ser Gly Glu Cys Asp

55 60 65gtg gct gtg cac tcc atg aag gat ctg ccg acc gcc acc gat cct cga 355Val Ala Val His Ser Met Lys Asp Leu Pro Thr Ala Thr Asp Pro Arg 7075 80 85ttc cac ctg gtc gtg cca act cgt gcg gac tck cgc cga ggs cct tat 403Phe His Leu Val Val Pro Thr Arg Ala Asp Xaa Arg Arg Xaa Pro Tyr

90 95 100cgc ccn cga cgg sct gan ttt kgg ttr agc tty caa aar gsg saa agg 451Arg Pro Arg Arg Xaa Xaa Phe Xaa Xaa Ser Xaa Gln Xaa Xaa Xaa Arg

105 110 115tgg gaa ctt tcc gct cct cga cgc atc tcc cag ctc aag gca atc cgc 499Trp Glu Leu Ser Ala Pro Arg Arg Ile Ser Gln Leu Lys Ala Ile Arg

120 125 130cct gac ctg gag att ctc cca ctt gcg cgg aaa cat tgacaccggc 545Pro Asp Leu Glu Ile Leu Pro Leu Ala Arg Lys His

135140145 atgggcaagg tca<210>806<211>145<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>VARIANT<222>96<223>Xaa ═ Ser<220><221>VARIANT<222>99<223>Xaa ═ Gly<220><221>VARIANT<222>106<223>Xaa ═ Ala or Pro<220><221>VARIANT<222>107<223>Xaa ═ Asp or<220><221>VARIANT<222>109<Xaa ═ Gly or<220><221>VARIANT<222>110<223>Xaa ═ Leu<220><221>VARIANT<222>112<220>Xaa<220>Gly<221>VARIANT<222>Xaa<223>Gly<220>Xaa<221>VARIANT<222>Xaa<223>Gly<220>Xaa<221>VARIANT<221>Xaa<222<223>VARIANT<220>Xaa<220>Gly<220>Xaa<220>VARIANT<220>Xaa<221>VARIANT<Glu (glutamic acid)

20 25 30Leu His Ile Val Thr Thr Pro Gly Asp Val Asn Met Ser Pro Val Glu

35 40 45Arg Ile Gly Val Gly Val Phe Thr Gln Ala Leu Arg Asp Val Leu His

50 55 60Ser Gly Glu Cys Asp Val Ala Val His Ser Met Lys Asp Leu Pro Thr 65 70 75 80Ala Thr Asp Pro Arg Phe His Leu Val Val Pro Thr Arg Ala Asp Xaa

85 90 95Arg Arg Xaa Pro Tyr Arg Pro Arg Arg Xaa Xaa Phe Xaa Xaa Ser Xaa

100 105 110Gln Xaa Xaa Xaa Arg Trp Glu Leu Ser Ala Pro Arg Arg Ile Ser Gln

115 120 125Leu Lys Ala Ile Arg Pro Asp Leu Glu Ile Leu Pro Leu Ala Arg Lys

130135140 His145<210>807<211>1245<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1222)<223>RXA00377<400>807aatggcgctc gggcagggcg cgcaagtact aaccagcaat tcccaagccc aaaaacccct 60cccatatagt tctttttact gatgcattgt cctcaattag gtg tgg ctt ctt ttc 115

Val Trp Leu Leu Phe

1 5cta aat tgg gat aaa tgg ggc aag att gag cgc atg tct gct ctt act 163Leu Asn Trp Asp Lys Trp Gly Lys Ile Glu Arg Met Ser Ala Leu Thr

10 15 20att cca gct gcg cgt cgc acg cta aat aac gcg ccc att att gat gcc 211Ile Pro Ala Ala Arg Arg Thr Leu Asn Asn Ala Pro Ile Ile Asp Ala

25 30 35gct aat ggc aag acc ccg act cgc act ccg gtg tgg ttt atg cgc cag 259Ala Asn Gly Lys Thr Pro Thr Arg Thr Pro Val Trp Phe MetArg Gln

40 45 50gcg ggt agg tcg ttg cct gag tac aag aag gtc cgt gag gga atc agc 307Ala Gly Arg Ser Leu Pro Glu Tyr Lys Lys Val Arg Glu Gly Ile Ser

55 60 65atg ttg gat tcc tgt ttc atg ccg gag ttg ttg gcg gag att act ttg 355Met Leu Asp Ser Cys Phe Met Pro Glu Leu Leu Ala Glu Ile Thr Leu 70 75 80 85cag ccg gtt cgt cgt cat gat gtg gat gct gcg att ttg ttc tct gac 403Gln Pro Val Arg Arg His Asp Val Asp Ala Ala Ile Leu Phe Ser Asp

90 95 100att gtg gtg ccg ttg cgt gct gcg ggt gtt ggt gtg gaa atc gtg gcg 451Ile Val Val Pro Leu Arg Ala Ala Gly Val Gly Val Glu Ile Val Ala

105 110 115ggt cgt gga cct gtg ttg gat gcg ccg gtg cgg agc cgt ggg gat gtg 499Gly Arg Gly Pro Val Leu Asp Ala Pro Val Arg Ser Arg Gly Asp Val

120 125 130ttg aat ctt cct att ttg gag ggc aac gtt ccg gag gtg gag cag ggt 547Leu Asn Leu Pro Ile Leu Glu Gly Asn Val Pro Glu Val Glu Gln Gly

135 140 145att ggc atc att ttg gat gag ttg tct gat tct cag gcg ttg att ggt 595Ile Gly Ile Ile Leu Asp Glu Leu Ser Asp Ser Gln Ala Leu Ile Gly150 155 160 165ttt gct ggt gcg ccg ttt acg ttg gcg agt tac ttg gtt gag ggt ggt 643Phe Ala Gly Ala Pro Phe Thr Leu Ala Ser Tyr Leu Val Glu Gly Gly

170 175 180cct tcc aag aat cat gag aag acc aaa gca atg atg cat ggt gat cct 691Pro Ser Lys Asn His Glu Lys Thr Lys Ala Met Met His Gly Asp Pro

185 190 195gag acg tgg cat gcg ttg atg gct cgt ttg gtg ccg acg att gtg aat 739Glu Thr Trp His Ala Leu Met Ala Arg Leu Val Pro Thr Ile Val Asn

200 205 210tct ttg aag tcg cag atc gat gcg ggt atc gat gcg gtg cag ttg ttt 787Ser Leu Lys Ser Gln Ile Asp Ala Gly Ile Asp Ala Val Gln Leu Phe

215 220 225gat tcg tgg gct ggg ttc ctc act gag cgt gat tac acc gag ttc gtg 835Asp Ser Trp Ala Gly Phe Leu Thr Glu Arg Asp Tyr Thr Glu Phe Val230 235 240 245ttg ccg tat tcc act gag att ttg gag gaa gtg ggc aag tac cag ctg 883Leu Pro Tyr Ser Thr Glu Ile Leu Glu Glu Val Gly Lys Tyr Gln Leu

250 255 260cct cgt att cac ttt ggt gtg ggt act ggt gag ttg ctt ggt gcg atg 931Pro Arg Ile His Phe Gly Val Gly Thr Gly Glu Leu Leu Gly Ala Met

265 270 275agc aag gct ggc tca gag gtc atg ggt gtg gat tgg cgg gtg ccg ttg 979Ser Lys Ala Gly Ser Glu Val Met Gly Val Asp Trp Arg Val Pro Leu

280 285 290gat aag gct gcg gag cgt att gct gcg gta tca ggt cct aag gtg ttg 1027Asp Lys Ala Ala Glu Arg Ile Ala Ala Val Ser Gly Pro Lys Val Leu

295 300 305cag ggt aac ctc gat cct gcg ttg ttg ttt gcg ggt cgc gca cct ttg 1075Gln Gly Asn Leu Asp Pro Ala Leu Leu Phe Ala Gly Arg Ala Pro Leu310 315 320 325act aag gaa att gag cgc atc aag gca gag gct cag act gct gtt gat 1123Thr Lys Glu Ile Glu Arg Ile Lys Ala Glu Ala Gln Thr Ala Val Asp

330 335 340gca ggt cat gca acg ggc cat atc ttt aac ctt ggt cat ggt gtg ctt 1171Ala Gly His Ala Thr Gly His Ile Phe Asn Leu Gly His Gly Val Leu

345 350 355cct aat acg gtg gcg gaa gat att act gaa gcc gtc tcc atc att cat 1219Pro Asn Thr Val Ala Glu Asp Ile Thr Glu Ala Val Ser Ile Ile His

360365370 tct taaactaaga ggagtttcat gcg 1245Ser<210>808<211>374<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>808Val Trp Leu Leu Phe Leu Asn Trp Asp Lys Trp Gly Lys Ile Glu Arg 151015 Met Ser Ala Leu Thr Ile Pro Ala Ala Arg Arg Thr Leu Asn Asn Ala

20 25 30Pro Ile Ile Asp Ala Ala Asn Gly Lys Thr Pro Thr Arg Thr Pro Val

35 40 45Trp Phe Met Arg Gln Ala Gly Arg Ser Leu Pro Glu Tyr Lys Lys Val

50 55 60Arg Glu Gly Ile Ser Met Leu Asp Ser Cys Phe Met Pro Glu Leu Leu 65 70 75 80Ala Glu Ile Thr Leu Gln Pro Val Arg Arg His Asp Val Asp Ala Ala

85 90 95Ile Leu Phe Ser Asp Ile Val Val Pro Leu Arg Ala Ala Gly Val Gly

100 105 110Val Glu Ile Val Ala Gly Arg Gly Pro Val Leu Asp Ala Pro Val Arg

115 120 125Ser Arg Gly Asp Val Leu Asn Leu Pro Ile Leu Glu Gly Asn Val Pro

130 135 140Glu Val Glu Gln Gly Ile Gly Ile Ile Leu Asp Glu Leu Ser Asp Ser145 150 155 160Gln Ala Leu Ile Gly Phe Ala Gly Ala Pro Phe Thr Leu Ala Ser Tyr

165 170 175Leu Val Glu Gly Gly Pro Ser Lys AsnHis Glu Lys Thr Lys Ala Met

180 185 190Met His Gly Asp Pro Glu Thr Trp His Ala Leu Met Ala Arg Leu Val

195 200 205Pro Thr Ile Val Asn Ser Leu Lys Ser Gln Ile Asp Ala Gly Ile Asp

210 215 220Ala Val Gln Leu Phe Asp Ser Trp Ala Gly Phe Leu Thr Glu Arg Asp225 230 235 240Tyr Thr Glu Phe Val Leu Pro Tyr Ser Thr Glu Ile Leu Glu Glu Val

245 250 255Gly Lys Tyr Gln Leu Pro Arg Ile His Phe Gly Val Gly Thr Gly Glu

260 265 270Leu Leu Gly Ala Met Ser Lys Ala Gly Ser Glu Val Met Gly Val Asp

275 280 285Trp Arg Val Pro Leu Asp Lys Ala Ala Glu Arg Ile Ala Ala Val Ser

290 295 300Gly Pro Lys Val Leu Gln Gly Asn Leu Asp Pro Ala Leu Leu Phe Ala305 310 315 320Gly Arg Ala Pro Leu Thr Lys Glu Ile Glu Arg Ile Lys Ala Glu Ala

325 330 335Gln Thr Ala Val Asp Ala Gly His Ala Thr Gly His Ile Phe Asn Leu

340 345 350Gly His Gly Val Leu Pro Asn Thr Val Ala Glu Asp Ile Thr Glu Ala

355 360 365Val Ser Ile Ile His Ser

370<210>809<211>681<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (658)<223>RXN02504<400>809cctcgattcc acctggtcgt gccaactcgtgcggactcgc gcgaggccct tatcgcccgc 60gacggcctga ctctggctga gcttccagaa aggcgcaaag gtg gga act tcc gct 115

Val Gly Thr Ser Ala

1 5cct cga cgc atc tcc cag ctc aag gca atc cgc cct gac ctg gag att 163Pro Arg Arg Ile Ser Gln Leu Lys Ala Ile Arg Pro Asp Leu Glu Ile

10 15 20ctc cca ctg cgc gga aac att gac acc ggc atg ggc aag gtc acc tcc 211Leu Pro Leu Arg Gly Asn Ile Asp Thr Gly Met Gly Lys Val Thr Ser

25 30 35ggt gaa ctc gat gct gtg atg ctc gcc tac gca ggc ctc acc cgc gtc 259Gly Glu Leu Asp Ala Val Met Leu Ala Tyr Ala Gly Leu Thr Arg Val

40 45 50ggc atg cag gac cgc gca acg gaa gtt ttc gac gcc gac atc atc atg 307Gly Met Gln Asp Arg Ala Thr Glu Val Phe Asp Ala Asp Ile Ile Met

55 60 65ccc gcc ccc gca cag ggc gca ctt gcg atc gaa tgc cgc gcc gac gac 355Pro Ala Pro Ala Gln Gly Ala Leu Ala Ile Glu Cys Arg Ala Asp Asp 70 75 80 85act gaa acc gtc cgc gcg ctc aac atg ctg atg cac gcc gac acg ttt 403Thr Glu Thr Val Arg Ala Leu Asn Met Leu Met His Ala Asp Thr Phe

90 95 100gtt tcc gcg gtt gca gaa cgc acc gtg ctc aac cgc ctc gaa gct ggc 451Val Ser Ala Val Ala Glu Arg Thr Val Leu Asn Arg Leu Glu Ala Gly

105 110 115tgt acc gcg cct gtc gca gcg cac gcc acc ttg gac ggc tac tcc ggc 499Cys Thr Ala Pro Val Ala Ala His Ala Thr Leu Asp Gly Tyr Ser Gly

120 125130gac acc atg act ctc acc gcc ggc gtc tac gca ctt gac ggc tct gac 547Asp Thr Met Thr Leu Thr Ala Gly Val Tyr Ala Leu Asp Gly Ser Asp

135 140 145cag ctg gta ttc tcc gcc gaa ggt gac ggc gcc cgc cca gaa gag ctc 595Gln Leu Val Phe Ser Ala Glu Gly Asp Gly Ala Arg Pro Glu Glu Leu150 155 160 165ggc gag ctc gtt gca caa cag ctt atc gac gcc gga gcc gcc aat ttg 643Gly Glu Leu Val Ala Gln Gln Leu Ile Asp Ala Gly Ala Ala Asn Leu

170 175 180ctc ggc gac cgc agc taattagggc ccgaaatttc cat 681Leu Gly Asp Arg Ser

185<210>810<211>186<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>810Val Gly Thr Ser Ala Pro Arg Arg Ile Ser Gln Leu Lys Ala Ile Arg 151015 Pro Asp Leu Glu Ile Leu Pro Leu Arg Gly Asn Ile Asp Thr Gly Met

20 25 30Gly Lys Val Thr Ser Gly Glu Leu Asp Ala Val Met Leu Ala Tyr Ala

35 40 45Gly Leu Thr Arg Val Gly Met Gln Asp Arg Ala Thr Glu Val Phe Asp

50 55 60Ala Asp Ile Ile Met Pro Ala Pro Ala Gln Gly Ala Leu Ala Ile Glu 65 70 75 80Cys Arg Ala Asp Asp Thr Glu Thr Val Arg Ala Leu Asn Met Leu Met

85 90 95His Ala Asp Thr Phe Val Ser Ala Val Ala Glu Arg Thr Val Leu Asn

100 105 110Arg Leu Glu Ala Gly Cys Thr Ala Pro Val Ala Ala His Ala Thr Leu

115 120 125Asp Gly Tyr Ser Gly Asp Thr Met Thr Leu Thr Ala Gly Val Tyr Ala

130 135 140Leu Asp Gly Ser Asp Gln Leu Val Phe Ser Ala Glu Gly Asp Gly Ala145 150 155 160Arg Pro Glu Glu Leu Gly Glu Leu Val Ala Gln Gln Leu Ile Asp Ala

165 170 175Gly Ala Ala Asn Leu Leu Gly Asp Arg Ser

180185<210>811<211>561<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (538)<223>FRXA02504<400>811gcatctccca gctcaaggca atccgccctg acctggagat tctcccactt gcgcggaaac 60attgacaccg gcatgggcaa ggtcacctcc ggtgaactcg atg ctt gtg atg ctc 115

Met Leu Val Met Leu

1 5gcc tac gca ggc ctc acc cgc gtc ggc atg cag gac cgc gca acg gaa 163Ala Tyr Ala Gly Leu Thr Arg Val Gly Met Gln Asp Arg Ala Thr Glu

10 15 20gtt ttc gac gcc gac atc atc atg ccc gcc ccc gca cag ggc gca ctt 211Val Phe Asp Ala Asp Ile Ile Met Pro Ala Pro Ala Gln Gly Ala Leu

25 30 35gcg atc gaa tgc cgc gcc gac gac act gaa acc gtc cgc gcg ctc aac 259Ala Ile Glu Cys Arg Ala Asp Asp Thr Glu Thr Val Arg Ala Leu Asn

40 45 50atg ctg atg cac gcc gac acg ttt gtt tcc gcg gtt gca gaa cgc acc 307Met Leu Met His Ala Asp Thr Phe Val Ser Ala Val Ala Glu Arg Thr

55 60 65gtg ctc aac cgc ctc gaa gct ggc tgt acc gcg cct gtc gca gcg cac 355Val Leu Asn Arg Leu Glu Ala Gly Cys Thr Ala Pro Val Ala AlaHis 70 75 80 85gcc acc ttg gac ggc tac tcc ggc gac acc atg act ctc acc gcc ggc 403Ala Thr Leu Asp Gly Tyr Ser Gly Asp Thr Met Thr Leu Thr Ala Gly

90 95 100gtc tac gca ctt gac ggc tct gac cag ctg gta ttc tcc gcc gaa ggt 451Val Tyr Ala Leu Asp Gly Ser Asp Gln Leu Val Phe Ser Ala Glu Gly

105 110 115gac ggc gcc cgc cca gaa gag ctc ggc gag ctc gtt gca caa cag ctt 499Asp Gly Ala Arg Pro Glu Glu Leu Gly Glu Leu Val Ala Gln Gln Leu

120 125 130atc gac gcc gga gcc gcc aat ttg ctc ggc gac cgc agc taattagggc 548Ile Asp Ala Gly Ala Ala Asn Leu Leu Gly Asp Arg Ser

135140145 ccgaaatttc cat 561<210>812<211>146<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>812Met Leu Val Met Leu Ala Tyr Ala Gly Leu Thr Arg Val Gly Met Gln 151015 Asp Arg Ala Thr Glu Val Phe Asp Ala Asp Ile Ile Met Pro Ala Pro

20 25 30Ala Gln Gly Ala Leu Ala Ile Glu Cys Arg Ala Asp Asp Thr Glu Thr

35 40 45Val Arg Ala Leu Asn Met Leu Met His Ala Asp Thr Phe Val Ser Ala

50 55 60Val Ala Glu Arg Thr Val Leu Asn Arg Leu Glu Ala Gly Cys Thr Ala 65 70 75 80Pro Val Ala Ala His Ala Thr Leu Asp Gly Tyr Ser Gly Asp Thr Met

85 90 95Thr Leu Thr Ala Gly Val Tyr Ala Leu Asp Gly Ser Asp Gln Leu Val

100 105 110Phe Ser Ala Glu Gly Asp Gly Ala Arg Pro Glu Glu Leu Gly Glu Leu

115 120 125Val Ala Gln Gln Leu Ile Asp Ala Gly Ala Ala Asn Leu Leu Gly Asp

130135140 Arg Ser145<210>813<211>1449<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1426)<223>RXN01162<400>813catcgaatac gtgccctgct gaatagatga catcgcagag atctataaga gtcagtggtt 60gtcggggttt cacagtcact tattctatgc aggattcacc atg tat atc gtg ggg 115

Met Tyr Ile Val Gly

1 5att tgt cta caa tta gtg gtt atg agc caa ccg atg tca gca ccc gac 163Ile Cys Leu Gln Leu Val Val Met Ser Gln Pro Met Ser Ala Pro Asp

10 15 20tcc gct cca gga aca gag cgc ggt cat gaa cgc acc cat ttt gcg gta 211Ser Ala Pro Gly Thr Glu Arg Gly His Glu Arg Thr His Phe Ala Val

25 30 35gtc ggt gac tcc cag gat cca gca cag gca aca gct cct aga gcg cca 259Val Gly Asp Ser Gln Asp Pro Ala Gln Ala Thr Ala Pro Arg Ala Pro

40 45 50gca gaa tca att act ttg att ggt att ggt acc gat ggg ttt gag ggg 307Ala Glu Ser Ile Thr Leu Ile Gly Ile Gly Thr Asp Gly Phe Glu Gly

55 60 65ctc gga ctc aag gca cag caa gca tta caa cgt gcc tct gtg gtg att 355Leu Gly Leu Lys Ala Gln Gln Ala Leu Gln Arg Ala Ser Val Val Ile 70 75 80 85gga tca tgg cgc cag ctc aat ctc gta cct gat gcc att aag gca gag 403Gly Ser Trp Arg Gln Leu Asn Leu Val Pro Asp Ala Ile Lys Ala Glu

90 95 100cgt cgc cca tgg ccg ggt aat acc aag cat cct gat tta gat gcc ttg 451Arg Arg Pro Trp Pro Gly Asn Thr Lys His Pro Asp Leu Asp Ala Leu

105 110 115ttt aaa gag ttc ctc ggt cgg cat gtt gct gtt ctg gcc tct ggc gat 499Phe Lys Glu Phe Leu Gly Arg His Val Ala Val Leu Ala Ser Gly Asp

120 125 130cca ctg ttt tac ggc gtg ggc acc gca atg gtc cat gtg ctg ggg atg 547Pro Leu Phe Tyr Gly Val Gly Thr Ala Met Val His Val Leu Gly Met

135 140 145gat aga ctc acg gtt att ccg gga cca tca tcc gcg tcg ctt gct tgc 595Asp Arg Leu Thr Val Ile Pro Gly Pro Ser Ser Ala Ser Leu Ala Cys150 155 160 165gcc cgc ttg ggt tgg aca gtc aac cgc aca cgg gtg gtg tac cta gga 643Ala Arg Leu Gly Trp Thr Val Asn Arg Thr Arg Val Val Tyr Leu Gly

170 175 180caa gaa ccc att gag aca ctc atc ccg att att gaa tca ggc gct caa 691Gln Glu Pro Ile Glu Thr Leu Ile Pro Ile Ile Glu Ser Gly Ala Gln

185 190 195ttc ctc gtc ttg ggt aaa gat gaa ttc agt aca gct caa gtt gcc acg 739Phe Leu Val Leu Gly Lys Asp Glu Phe Ser Thr Ala Gln Val Ala Thr

200 205 210ttg ttg aat gaa ctc gga ctg ggg gag act cca ctg act gtg ctc agc 787Leu Leu Asn Glu Leu Gly Leu Gly Glu Thr Pro Leu Thr Val Leu Ser

215 220 225gat ttg ggc agt act gat gag gag atc acc caa ggc aca gct tca cat 835Asp Leu Gly Ser Thr Asp Glu Glu Ile Thr Gln Gly Thr Ala Ser His230 235 240 245cca cca gct gca gtg tct gtt ctc aac gtg att gct gtg gga gct cgc883Pro Pro Ala Ala Val Ser Val Leu Asn Val Ile Ala Val Gly Ala Arg

250 255 260acc gca atg ccg aaa ccc cac ttt gaa ggc gac gta tca aac gaa gac 931Thr Ala Met Pro Lys Pro His Phe Glu Gly Asp Val Ser Asn Glu Asp

265 270 275ctt cgg gca ctg acc gtg gca gct cta gaa ccc acc cag gga caa atg 979Leu Arg Ala Leu Thr Val Ala Ala Leu Glu Pro Thr Gln Gly Gln Met

280 285 290ctg tgg acc ttc ggg gat att gga gca gca ctt gcc tgc gat tgg cta 1027Leu Trp Thr Phe Gly Asp Ile Gly Ala Ala Leu Ala Cys Asp Trp Leu

295 300 305cgc gca gcc ggc aac aag gcg cac gcc att agt ttt gcc tcc atg gtt 1075Arg Ala Ala Gly Asn Lys Ala His Ala Ile Ser Phe Ala Ser Met Val310 315 320 325gag caa agc caa agg aat gct cgc aaa cta ggt gta tcc acc ctc agt 1123Glu Gln Ser Gln Arg Asn Ala Arg Lys Leu Gly Val Ser Thr Leu Ser

330 335 340gtg aaa gag acc ctg tca ccc aaa acg ctc aaa gat atc cgc tat gta 1171Val Lys Glu Thr Leu Ser Pro Lys Thr Leu Lys Asp Ile Arg Tyr Val

345 350 355caa gga cca gaa tca gca agc cca cat gcc atc ttc atg aac aaa ggc 1219Gln Gly Pro Glu Ser Ala Ser Pro His Ala Ile Phe Met Asn Lys Gly

360 365 370cta ggc atc gat cta gtt cct gaa acc gca tgg atg atg ctg cgg cct 1267Leu Gly Ile Asp Leu Val Pro Glu Thr Ala Trp Met Met Leu Arg Pro

375 380 385gga gga aag ctc att gcg caa gcc tcc aca gaa gac aac atc gca aag 1315Gly Gly Lys Leu Ile Ala Gln Ala Ser Thr Glu Asp Asn Ile Ala Lys390 395 400 405ctt cac aca ctc caa gaa caa cac ggc gga atc atc aaa cac atc cgc 1363Leu His Thr Leu Gln Glu Gln His Gly Gly Ile Ile Lys His Ile Arg

410 415 420atc gac gac aca gac gtg cac caa tgg cga gtt aca aag ccg gtg act 1411Ile Asp Asp Thr Asp Val His Gln Trp Arg Val Thr Lys Pro Val Thr

425 430 435cca gaa gcg gtg aat tagcatcaaa aaccaacccc atg 1449Pro Glu Ala Val Asn

440<210>814<211>442<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>814Met Tyr Ile Val Gly Ile Cys Leu Gln Leu Val Val Met Ser Gln Pro 151015 Met Ser Ala Pro Asp Ser Ala Pro Gly Thr Glu Arg Gly His Glu Arg

20 25 30Thr His Phe Ala Val Val Gly Asp Ser Gln Asp Pro Ala Gln Ala Thr

35 40 45Ala Pro Arg Ala Pro Ala Glu Ser Ile Thr Leu Ile Gly Ile Gly Thr

50 55 60Asp Gly Phe Glu Gly Leu Gly Leu Lys Ala Gln Gln Ala Leu Gln Arg 65 70 75 80Ala Ser Val Val Ile Gly Ser Trp Arg Gln Leu Asn Leu Val Pro Asp

85 90 95Ala Ile Lys Ala Glu Arg Arg Pro Trp Pro Gly Asn Thr Lys His Pro

100 105 110Asp Leu Asp Ala Leu Phe Lys Glu Phe Leu Gly Arg His Val Ala Val

115 120 125Leu Ala Ser Gly Asp Pro Leu Phe Tyr Gly Val Gly Thr Ala Met Val

130 135 140His Val Leu Gly Met Asp Arg Leu Thr Val Ile Pro Gly Pro Ser Ser145 150 155 160Ala Ser Leu Ala Cys Ala Arg Leu Gly Trp Thr Val Asn Arg Thr Arg

165 170 175Val Val Tyr Leu Gly Gln Glu Pro Ile Glu Thr Leu Ile Pro Ile Ile

180 185 190Glu Ser Gly Ala Gln Phe Leu Val Leu Gly Lys Asp Glu Phe Ser Thr

195 200 205Ala Gln Val Ala Thr Leu Leu Asn Glu Leu Gly Leu Gly Glu Thr Pro

210 215 220Leu Thr Val Leu Ser Asp Leu Gly Ser Thr Asp Glu Glu Ile Thr Gln225 230 235 240Gly Thr Ala Ser His Pro Pro Ala Ala Val Ser Val Leu Asn Val Ile

245 250 255Ala Val Gly Ala Arg Thr Ala Met Pro Lys Pro His Phe Glu Gly Asp

260 265 270Val Ser Asn Glu Asp Leu Arg Ala Leu Thr Val Ala Ala Leu Glu Pro

275 280 285Thr Gln Gly Gln Met Leu Trp Thr Phe Gly Asp Ile Gly Ala Ala Leu

290 295 300Ala Cys Asp Trp Leu Arg Ala Ala Gly Asn Lys Ala His Ala Ile Ser305 310 315 320Phe Ala Ser Met Val Glu Gln Ser Gln Arg Asn Ala Arg Lys Leu Gly

325 330 335Val Ser Thr Leu Ser Val Lys Glu Thr Leu Ser Pro Lys Thr Leu Lys

340 345 350Asp Ile Arg Tyr Val Gln Gly Pro Glu Ser Ala Ser Pro His Ala Ile

355 360365Phe Met Asn Lys Gly Leu Gly Ile Asp Leu Val Pro Glu Thr Ala Trp

370 375 380Met Met Leu Arg Pro Gly Gly Lys Leu Ile Ala Gln Ala Ser Thr Glu385 390 395 400Asp Asn Ile Ala Lys Leu His Thr Leu Gln Glu Gln His Gly Gly Ile

405 410 415Ile Lys His Ile Arg Ile Asp Asp Thr Asp Val His Gln Trp Arg Val

420 425 430Thr Lys Pro Val Thr Pro Glu Ala Val Asn

435440<210>815<211>1345<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1345)<223>FRXA01162<400>815catcgaatac gtgccctgct gaatagatga catcgcagag atctataaga gtcagtggtt 60gtcggggttt cacagtcact tattctatgc aggattcacc atg tat atc gtg ggg 115

Met Tyr Ile Val Gly

1 5att tgt cta caa tta gtg gtt atg agc caa ccg atg tca gca ccc gac 163Ile Cys Leu Gln Leu Val Val Met Ser Gln Pro Met Ser Ala Pro Asp

10 15 20tcc gct cca gga aca gag cgc ggt cat gaa cgc acc cat ttt gcg gta 211Ser Ala Pro Gly Thr Glu Arg Gly His Glu Arg Thr His Phe Ala Val

25 30 35gtc ggt gac tcc cag gat cca gca cag gca aca gct cct aga gcg cca 259Val Gly Asp Ser Gln Asp Pro Ala Gln Ala Thr Ala Pro Arg Ala Pro

40 45 50gca gaa tca att act ttg att ggt att ggt acc gat ggg ttt gag ggg 307Ala Glu Ser Ile Thr Leu Ile Gly Ile Gly Thr Asp Gly Phe Glu Gly

55 60 65ctc gga ctc aag gca cag caa gca tta caa cgt gcc tct gtg gtg att 355Leu Gly Leu Lys Ala Gln Gln Ala Leu Gln Arg Ala Ser Val Val Ile 70 75 80 85gga tca tgg cgc cag ctc aat ctc gta cct gat gcc att aag gca gag 403Gly Ser Trp Arg Gln Leu Asn Leu Val Pro Asp Ala Ile Lys Ala Glu

90 95 100cgt cgc cca tgg ccg ggt aat acc aag cat cct gat tta gat gcc ttg 451Arg Arg Pro Trp Pro Gly Asn Thr Lys His Pro Asp Leu Asp Ala Leu

105 110 115ttt aaa gag ttc ctc ggt cgg cat gtt gct gtt ctg gcc tct ggc gat 499Phe Lys Glu Phe Leu Gly Arg His Val Ala Val Leu Ala Ser Gly Asp

120 125 130cca ctg ttt tac ggc gtg ggc acc gca atg gtc cat gtg ctg ggg atg 547Pro Leu Phe Tyr Gly Val Gly Thr Ala Met Val His Val Leu Gly Met

135 140 145gat aga ctc acg gtt att ccg gga cca tca tcc gcg tcg ctt gct tgc 595Asp Arg Leu Thr Val Ile Pro Gly Pro Ser Ser Ala Ser Leu Ala Cys150 155 160 165gcc cgc ttg ggt tgg aca gtc aac cgc aca cgg gtg gtg tac cta gga 643Ala Arg Leu Gly Trp Thr Val Asn Arg Thr Arg Val Val Tyr Leu Gly

170 175 180caa gaa ccc att gag aca ctc atc ccg att att gaa tca ggc gct caa 691Gln Glu Pro Ile Glu Thr Leu Ile Pro Ile Ile Glu Ser Gly Ala Gln

185 190 195ttc ctc gtc ttg ggt aaa gat gaa ttc agt aca gct caa gtt gcc acg 739Phe Leu Val Leu Gly Lys Asp Glu Phe Ser Thr Ala Gln Val Ala Thr

200 205 210ttg ttg aat gaa ctc gga ctg ggg gag act cca ctg act gtg ctc agc 787Leu Leu Asn Glu Leu Gly Leu Gly Glu Thr Pro Leu Thr Val Leu Ser

215 220 225gat ttg ggc agt act gat gag gag atc acc caa ggc aca gct tca cat 835Asp Leu Gly Ser Thr Asp Glu Glu Ile Thr Gln Gly Thr Ala Ser His230 235 240 245cca cca gct gca gtg tct gtt ctc aac gtg att gct gtg gga gct cgc 883Pro Pro Ala Ala Val Ser Val Leu Asn Val Ile Ala Val Gly Ala Arg

250 255 260acc gca atg ccg aaa ccc cac ttt gaa ggc gac gta tca aac gaa gac 931Thr Ala Met Pro Lys Pro His Phe Glu Gly Asp Val Ser Asn Glu Asp

265 270 275ctt cgg gca ctg acc gtg gca gct cta gaa ccc acc cag gga caa atg 979Leu Arg Ala Leu Thr Val Ala Ala Leu Glu Pro Thr Gln Gly Gln Met

280 285 290ctg tgg acc ttc ggg gat att gga gca gca ctt gcc tgc gat tgg cta 1027Leu Trp Thr Phe Gly Asp Ile Gly Ala Ala Leu Ala Cys Asp Trp Leu

295 300 305cgc gca gcc ggc aac aag gcg cac gcc att agt ttt gcc tcc atg gtt 1075Arg Ala Ala Gly Asn Lys Ala His Ala Ile Ser Phe Ala Ser Met Val310 315 320 325gag caa agc caa agg aat gct cgc aaa cta ggt gta tcc acc ctc agt 1123Glu Gln Ser Gln Arg Asn Ala Arg Lys Leu Gly Val Ser Thr Leu Ser

330 335 340gtg aaa gag acc ctg tca ccc aaa acg ctc aaa gat atc cgc tat gta 1171Val Lys Glu Thr Leu Ser Pro Lys Thr Leu Lys Asp Ile Arg Tyr Val

345 350 355caa gga cca gaa tca gca agc cca cat gcc atc ttc atg aac aaa ggc 1219Gln Gly Pro Glu Ser Ala Ser Pro His Ala Ile Phe Met Asn Lys Gly

360 365 370cta ggc atc gat cta gtt cct gaa acc gca tgg atg atg ctg cgg cct 1267Leu Gly Ile Asp Leu Val Pro Glu Thr Ala Trp Met Met Leu Arg Pro

375 380 385gga gga aag ctc att gcg caa gcc tcc aca gaa gac aac atc gca aag 1315Gly Gly Lys Leu Ile Ala Gln Ala Ser Thr Glu Asp Asn Ile Ala Lys390 395 400 405ctt cac aca ctc caa gaa caa cac ggc gga 1345Leu His Thr Leu Gln Glu Gln His Gly Gly

410415<210>816<211>415<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>816Met Tyr Ile Val Gly Ile Cys Leu Gln Leu Val Val Met Ser Gln Pro 151015 Met Ser Ala Pro Asp Ser Ala Pro Gly Thr Glu Arg Gly His Glu Arg

20 25 30Thr His Phe Ala Val Val Gly Asp Ser Gln Asp Pro Ala Gln Ala Thr

35 40 45Ala Pro Arg Ala Pro Ala Glu Ser Ile Thr Leu Ile Gly Ile Gly Thr

50 55 60Asp Gly Phe Glu Gly Leu Gly Leu Lys Ala Gln Gln Ala Leu Gln Arg 65 70 75 80Ala Ser Val Val Ile Gly Ser Trp Arg Gln Leu Asn Leu Val Pro Asp

85 90 95Ala Ile Lys Ala Glu Arg Arg Pro Trp Pro Gly Asn Thr Lys His Pro

100 105 110Asp Leu Asp Ala Leu Phe Lys Glu Phe Leu Gly Arg His Val Ala Val

115 120 125Leu Ala Ser Gly Asp Pro Leu Phe Tyr Gly Val Gly Thr Ala Met Val

130 135 140HisVal Leu Gly Met Asp Arg Leu Thr Val Ile Pro Gly Pro Ser Ser145 150 155 160Ala Ser Leu Ala Cys Ala Arg Leu Gly Trp Thr Val Asn Arg Thr Arg

165 170 175Val Val Tyr Leu Gly Gln Glu Pro Ile Glu Thr Leu Ile Pro Ile Ile

180 185 190Glu Ser Gly Ala Gln Phe Leu Val Leu Gly Lys Asp Glu Phe Ser Thr

195 200 205Ala Gln Val Ala Thr Leu Leu Asn Glu Leu Gly Leu Gly Glu Thr Pro

210 215 220Leu Thr Val Leu Ser Asp Leu Gly Ser Thr Asp Glu Glu Ile Thr Gln225 230 235 240Gly Thr Ala Ser His Pro Pro Ala Ala Val Ser Val Leu Asn Val Ile

245 250 255Ala Val Gly Ala Arg Thr Ala Met Pro Lys Pro His Phe Glu Gly Asp

260 265 270Val Ser Asn Glu Asp Leu Arg Ala Leu Thr Val Ala Ala Leu Glu Pro

275 280 285Thr Gln Gly Gln Met Leu Trp Thr Phe Gly Asp Ile Gly Ala Ala Leu

290 295 300Ala Cys Asp Trp Leu Arg Ala Ala Gly Asn Lys Ala His Ala Ile Ser305 310 315 320Phe Ala Ser Met Val Glu Gln Ser Gln Arg Asn Ala Arg Lys Leu Gly

325 330 335Val Ser Thr Leu Ser Val Lys Glu Thr Leu Ser Pro Lys Thr Leu Lys

340 345 350Asp Ile Arg Tyr Val Gln Gly Pro Glu Ser Ala Ser Pro His Ala Ile

355 360365Phe Met Asn Lys Gly Leu Gly Ile Asp Leu Val Pro Glu Thr Ala Trp

370 375 380Met Met Leu Arg Pro Gly Gly Lys Leu Ile Ala Gln Ala Ser Thr Glu385 390 395 400Asp Asn Ile Ala Lys Leu His Thr Leu Gln Glu Gln His Gly Gly

405410415<210>817<211>873<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (850)<223>RXA01692<400>817gggctgatgc gaagtcagct tcgagtttga aaggtgcagt attcatggtt caagcctagt 60gttcgggttc tggcaattgt tgggactagg attaatgccc atg acg att tcc caa 115

Met Thr Ile Ser Gln

1 5gaa aac cag cca ata atc cag cca gtc tcc tta att ggt gga ggt cct 163Glu Asn Gln Pro Ile Ile Gln Pro Val Ser Leu Ile Gly Gly Gly Pro

10 15 20ggt gca tgg gac tta att acg gtg cgt ggg atg aat cgc ctt cag gag 211Gly Ala Trp Asp Leu Ile Thr Val Arg Gly Met Asn Arg Leu Gln Glu

25 30 35gct gat gtc att ttg gct gat cac ttg ggg ccc act gat gag ttg gaa 259Ala Asp Val Ile Leu Ala Asp His Leu Gly Pro Thr Asp Glu Leu Glu

40 45 50aaa ttg tgc gac atc agc tcg aag act gtt gtt gat gtg tcc aag ctt 307Lys Leu Cys Asp Ile Ser Ser Lys Thr Val Val Asp Val Ser Lys Leu

55 60 65ccg tat ggg cgg cag gtc act cag gag cgt act aat gag atg ctt gtt 355Pro Tyr Gly Arg Gln Val Thr Gln Glu Arg Thr Asn Glu Met Leu Val 70 75 80 85gaa tac gca cag cag gga cta aag gtg gtt cgc ctt aaa ggt ggt gac 403Glu Tyr Ala Gln Gln Gly Leu Lys Val Val Arg Leu Lys Gly Gly Asp

90 95 100cct tat gtc ttc ggt cgg ggt ttt gaa gag ttg gag ttt ttg ggc gag 451Pro Tyr Val Phe Gly Arg Gly Phe Glu Glu Leu Glu Phe Leu Gly Glu

105 110 115cat gga att gaa tgc gag gtc att ccg ggt gtg acc agt gcg gtg tcc 499His Gly Ile Glu Cys Glu Val Ile Pro Gly Val Thr Ser Ala Val Ser

120 125 130gtt cca gcg gcg gca ggt att cct att act aat cgg gga gtg gtg cat 547Val Pro Ala Ala Ala Gly Ile Pro Ile Thr Asn Arg Gly Val Val His

135 140 145tcc ttt acc gtg gtg tct gga cat ttg cct cca ggc cat ccg aag tca 595Ser Phe Thr Val Val Ser Gly His Leu Pro Pro Gly His Pro Lys Ser150 155 160 165ctg gtt gat tgg gct gcg ttg gcc aaa tcg ggt ggc acc ttg tcc atc 643Leu Val Asp Trp Ala Ala Leu Ala Lys Ser Gly Gly Thr Leu Ser Ile

170 175 180atc atg ggt gtg aaa aat gcg ggt gcg att gcc cag gcg ctc atg gac 691Ile Met Gly Val Lys Asn Ala Gly Ala Ile Ala Gln Ala Leu Met Asp

185 190 195ggc ggg ctt gat gca gat act cca gca gct gtt att cag gaa ggc act 739Gly Gly Leu Asp Ala Asp Thr Pro Ala Ala Val Ile Gln Glu Gly Thr

200 205 210act gat gca caa cgc tca gtt cgg tgc acc ttg ggc aca ttg ggt gca 787Thr Asp Ala Gln Arg Ser Val Arg Cys Thr Leu Gly Thr Leu Gly Ala

215 220 225gtc atg gtg gag gaa gag att aag cct cca gct gtg tat gtc att gga 835Val Met Val Glu Glu Glu Ile Lys Pro Pro AlaVal Tyr Val Ile Gly230 235 240 245caa gtt gct ggc ctc taagcagatc gcctaagaat ggg 873Gln Val Ala Gly Leu

250<210>818<211>250<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>818Met Thr Ile Ser Gln Glu Asn Gln Pro Ile Ile Gln Pro Val Ser Leu 151015 Ile Gly Gly Gly Pro Gly Ala Trp Asp Leu Ile Thr Val Arg Gly Met

20 25 30Asn Arg Leu Gln Glu Ala Asp Val Ile Leu Ala Asp His Leu Gly Pro

35 40 45Thr Asp Glu Leu Glu Lys Leu Cys Asp Ile Ser Ser Lys Thr Val Val

50 55 60Asp Val Ser Lys Leu Pro Tyr Gly Arg Gln Val Thr Gln Glu Arg Thr 65 70 75 80Asn Glu Met Leu Val Glu Tyr Ala Gln Gln Gly Leu Lys Val Val Arg

85 90 95Leu Lys Gly Gly Asp Pro Tyr Val Phe Gly Arg Gly Phe Glu Glu Leu

100 105 110Glu Phe Leu Gly Glu His Gly Ile Glu Cys Glu Val Ile Pro Gly Val

115 120 125Thr Ser Ala Val Ser Val Pro Ala Ala Ala Gly Ile Pro Ile Thr Asn

130 135 140Arg Gly Val Val His Ser Phe Thr Val Val Ser Gly His Leu Pro Pro145 150 155 160Gly His Pro Lys Ser Leu Val Asp Trp Ala Ala Leu Ala Lys Ser Gly

165 170 175Gly Thr Leu Ser Ile Ile Met Gly Val Lys Asn Ala Gly Ala Ile Ala

180 185 190Gln Ala Leu Met Asp Gly Gly Leu Asp Ala Asp Thr Pro Ala Ala Val

195 200 205Ile Gln Glu Gly Thr Thr Asp Ala Gln Arg Ser Val Arg Cys Thr Leu

210 215 220Gly Thr Leu Gly Ala Val Met Val Glu Glu Glu Ile Lys Pro Pro Ala225 230 235 240Val Tyr Val Ile Gly Gln Val Ala Gly Leu

245250<210>819<211>1917<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1894)<223>RXN00371<400>819gtcgtggaca atcccggatc gaaaatttga ttcggctttt ttcatggctg ttgatggagt 60acgttggtcg ttttcgagac aagtactaga aaagatattg atg act atc gcc cat 115

Met Thr Ile Ala His

1 5aag ccc gag atg gct gaa act acc ggg atc gag acc aac cag gtt tcc 163Lys Pro Glu Met Ala Glu Thr Thr Gly Ile Glu Thr Asn Gln Val Ser

10 15 20gaa acc atc ggg gtt gaa tcg ctc acg cac gga aac tta cgt cct gtt 211Glu Thr Ile Gly Val Glu Ser Leu Thr His Gly Asn Leu Arg Pro Val

25 30 35tca tct ttt gag gga cag cat gag gga caa acg gaa gag tta ctt cca 259Ser Ser Phe Glu Gly Gln His Glu Gly Gln Thr Glu Glu Leu Leu Pro

40 45 50ggc aaa gtc att ttt gtt ggg gcc ggt ccc ggt aac cct gat ctt ctt 307Gly Lys Val Ile Phe Val Gly Ala Gly Pro Gly Asn Pro Asp Leu Leu

55 60 65aca gtt cgt gcc cgt gaa gtt ctg ggc aac gcg gtt cgt gcg att act 355Thr Val Arg Ala Arg Glu Val Leu Gly Asn Ala Val Arg Ala Ile Thr 70 75 80 85gat gaa caa gta cta agc ggc gtt cga gct ttt gtc gcc act gaa att 403Asp Glu Gln Val Leu Ser Gly Val Arg Ala Phe Val Ala Thr Glu Ile

90 95 100cct gtg ccg gaa gat aag ctt cag gct gcg gaa gat gag tac gag cgc 451Pro Val Pro Glu Asp Lys Leu Gln Ala Ala Glu Asp Glu Tyr Glu Arg

105 110 115atc tgc att gaa gcg aag gag aac ggt gca cgc cgt aag cct cct cgt 499Ile Cys Ile Glu Ala Lys Glu Asn Gly Ala Arg Arg Lys Pro Pro Arg

120 125 130cca gca cca cca acc gct gca gag atc acg gaa gtt tct gag gcg act 547Pro Ala Pro Pro Thr Ala Ala Glu Ile Thr Glu Val Ser Glu Ala Thr

135 140 145cca gct cag att gtt gag ctt gtg cag gat gct ctt tct tat ggt gga 595Pro Ala Gln Ile Val Glu Leu Val Gln Asp Ala Leu Ser Tyr Gly Gly150 155 160 165gat gtt att cgt ctt gtc acc ggc aac cca ttg agc agc gat gcc aca 643Asp Val Ile Arg Leu Val Thr Gly Asn Pro Leu Ser Ser Asp Ala Thr

170 175 180ctg gct gag atc tct gca gtt tcc gag gct ggc ctg gag ttc cag gtg 691Leu Ala Glu Ile Ser Ala Val Ser Glu Ala Gly Leu Glu Phe Gln Val

185 190 195gtt cca ggt atg tct ttg cct gca acg gtt cct gca ttt gcg gga att 739Val Pro Gly Met Ser Leu Pro Ala Thr Val Pro Ala Phe Ala Gly Ile

200 205 210gcg ttg ggt tct acc tac acc gaa act gat gtc aac ggt caa aac ttg 787Ala Leu Gly Ser Thr Tyr Thr Glu Thr Asp Val Asn Gly Gln Asn Leu

215 220 225gactgg gat cag ttg gct agc gca cct cag cct ttg gtg ctg cag gcc 835Asp Trp Asp Gln Leu Ala Ser Ala Pro Gln Pro Leu Val Leu Gln Ala230 235 240 245cgc gtg gat gac ctt tcc cgt att gca cag gaa cta aag gcc cgc aat 883Arg Val Asp Asp Leu Ser Arg Ile Ala Gln Glu Leu Lys Ala Arg Asn

250 255 260atg tct ttg gaa act cct gtt tct gtc acc gct aac ggc acc acc cgt 931Met Ser Leu Glu Thr Pro Val Ser Val Thr Ala Asn Gly Thr Thr Arg

265 270 275ttg cag cgc acc tat gac acc act tta ggt ctg ttg cac aag ctt gat 979Leu Gln Arg Thr Tyr Asp Thr Thr Leu Gly Leu Leu His Lys Leu Asp

280 285 290gct gaa cta agc gga cct ttg gtt gtt acc ttg ggc aag ggt gtg gat 1027Ala Glu Leu Ser Gly Pro Leu Val Val Thr Leu Gly Lys Gly Val Asp

295 300 305gat cgc tcc aag tac tct tgg tgg gaa aac cgc gct ctg tac ggt tgg 1075Asp Arg Ser Lys Tyr Ser Trp Trp Glu Asn Arg Ala Leu Tyr Gly Trp310 315 320 325cgt gtg ctg gtg cct cgc gct cgg gag caa gcg gca tcc atg tcc gca 1123Arg Val Leu Val Pro Arg Ala Arg Glu Gln Ala Ala Ser Met Ser Ala

330 335 340cgt ctg agc agc cac ggc gct atc ccg cag gaa gtc cct acc att tct 1171Arg Leu Ser Ser His Gly Ala Ile Pro Gln Glu Val Pro Thr Ile Ser

345 350 355gtc gaa cca ccg cgc aac cca gcg caa atg gaa cgc gcc atc aag ggc 1219Val Glu Pro Pro Arg Asn Pro Ala Gln Met Glu Arg Ala Ile Lys Gly

360 365 370atc gtc gaa gga cgc tac cag tgg gtt gtc ctc acc agc gtc aac gca 1267Ile Val Glu Gly Arg Tyr Gln Trp Val Val Leu Thr Ser Val Asn Ala

375 380 385gtg aag gca gtc tgg gag aaa atc acc gaa ttc ggc ctc gat tca cgt 1315Val Lys Ala Val Trp Glu Lys Ile Thr Glu Phe Gly Leu Asp Ser Arg390 395 400 405tcc ttc gcg ggc gtc cgc atc gcc gca gtc ggt gaa aaa acc gcc gct 1363Ser Phe Ala Gly Val Arg Ile Ala Ala Val Gly Glu Lys Thr Ala Ala

410 415 420gag atc cgc gcg ctc ggc atc acg ccg gag ctt ctg cct gca cgt acc 1411Glu Ile Arg Ala Leu Gly Ile Thr Pro Glu Leu Leu Pro Ala Arg Thr

425 430 435agg caa aat gcg caa ggg ctt gtc gac gtg ttc ccc gaa tat ttc gaa 1459Arg Gln Asn Ala Gln Gly Leu Val Asp Val Phe Pro Glu Tyr Phe Glu

440 445 450gaa ctc gat cca gtc ggc cgt gtc ctc ttg ccg cgc gca gat atc gca 1507Glu Leu Asp Pro Val Gly Arg Val Leu Leu Pro Arg Ala Asp Ile Ala

455 460 465acc gac gtg ctt gtc gac ggc ctg acc cac ctt ggt tgg gaa gtc gaa 1555Thr Asp Val Leu Val Asp Gly Leu Thr His Leu Gly Trp Glu Val Glu470 475 480 485gac gtg gtg gct tac cgc acc gtc cgc gca gca cca cca agc gct gat 1603Asp Val Val Ala Tyr Arg Thr Val Arg Ala Ala Pro Pro Ser Ala Asp

490 495 500atc cga gat atg atc aag acc ggc gga ttt gat gca gtt gcc ttc acc 1651Ile Arg Asp Met Ile Lys Thr Gly Gly Phe Asp Ala Val Ala Phe Thr

505 510 515tct tcg tcg acc gtg aag aac ctc gtt ggt atc gcg ggt aaa cca cac 1699Ser Ser Ser Thr Val Lys Asn Leu Val Gly Ile Ala Gly Lys Pro His

520525 530cca cgc acc atc gtc gcg tgc atc gga ccc atg act gca gcg acc gct 1747Pro Arg Thr Ile Val Ala Cys Ile Gly Pro Met Thr Ala Ala Thr Ala

535 540 545gaa gaa ctg gga ctg cgc gtt gat gtc atg cca gag atc gcc gaa gta 1795Glu Glu Leu Gly Leu Arg Val Asp Val Met Pro Glu Ile Ala Glu Val550 555 560 565cca gaa ctg atc gac gct ctt gcg gaa cac gtg gcg gat ctg cgc gct 1843Pro Glu Leu Ile Asp Ala Leu Ala Glu His Val Ala Asp Leu Arg Ala

570 575 580aag ggc gag ctg ccg ccg ccg agg aag aaa cgc agg cgt cga aaa gcg 1891Lys Gly Glu Leu Pro Pro Pro Arg Lys Lys Arg Arg Arg Arg Lys Ala

585590595 tct taaaaggttt ttcactaggg tgt 1917Ser<210>820<211>598<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>820Met Thr Ile Ala His Lys Pro Glu Met Ala Glu Thr Thr Gly Ile Glu 151015 Thr Asn Gln Val Ser Glu Thr Ile Gly Val Glu Ser Leu Thr His Gly

20 25 30Asn Leu Arg Pro Val Ser Ser Phe Glu Gly Gln His Glu Gly Gln Thr

35 40 45Glu Glu Leu Leu Pro Gly Lys Val Ile Phe Val Gly Ala Gly Pro Gly

50 55 60Asn Pro Asp Leu Leu Thr Val Arg Ala Arg Glu Val Leu Gly Asn Ala 65 70 75 80Val Arg Ala Ile Thr Asp Glu Gln Val Leu Ser Gly Val Arg Ala Phe

85 90 95Val Ala Thr Glu Ile Pro Val Pro Glu Asp Lys Leu Gln Ala Ala Glu

100 105 110Asp Glu Tyr Glu Arg Ile Cys Ile Glu Ala Lys Glu Asn Gly Ala Arg

115 120 125Arg Lys Pro Pro Arg Pro Ala Pro Pro Thr Ala Ala Glu Ile Thr Glu

130 135 140Val Ser Glu Ala Thr Pro Ala Gln Ile Val Glu Leu Val Gln Asp Ala145 150 155 160Leu Ser Tyr Gly Gly Asp Val Ile Arg Leu Val Thr Gly Asn Pro Leu

165 170 175Ser Ser Asp Ala Thr Leu Ala Glu Ile Ser Ala Val Ser Glu Ala Gly

180 185 190Leu Glu Phe Gln Val Val Pro Gly Met Ser Leu Pro Ala Thr Val Pro

195 200 205Ala Phe Ala Gly Ile Ala Leu Gly Ser Thr Tyr Thr Glu Thr Asp Val

210 215 220Asn Gly Gln Asn Leu Asp Trp Asp Gln Leu Ala Ser Ala Pro Gln Pro225 230 235 240Leu Val Leu Gln Ala Arg Val Asp Asp Leu Ser Arg Ile Ala Gln Glu

245 250 255Leu Lys Ala Arg Asn Met Ser Leu Glu Thr Pro Val Ser Val Thr Ala

260 265 270Asn Gly Thr Thr Arg Leu Gln Arg Thr Tyr Asp Thr Thr Leu Gly Leu

275 280 285Leu His Lys Leu Asp Ala Glu Leu Ser Gly Pro Leu Val Val Thr Leu

290 295 300Gly Lys Gly Val Asp Asp Arg Ser Lys Tyr Ser Trp Trp Glu Asn Arg305 310 315 320Ala Leu Tyr Gly Trp Arg Val Leu Val Pro Arg Ala Arg Glu Gln Ala

325 330 335Ala Ser Met Ser Ala Arg Leu Ser Ser His Gly Ala Ile Pro Gln Glu

340 345 350Val Pro Thr Ile Ser Val Glu Pro Pro Arg Asn Pro Ala Gln Met Glu

355 360 365Arg Ala Ile Lys Gly Ile Val Glu Gly Arg Tyr Gln Trp Val Val Leu

370 375 380Thr Ser Val Asn Ala Val Lys Ala Val Trp Glu Lys Ile Thr Glu Phe385 390 395 400Gly Leu Asp Ser Arg Ser Phe Ala Gly Val Arg Ile Ala Ala Val Gly

405 410 415Glu Lys Thr Ala Ala Glu Ile Arg Ala Leu Gly Ile Thr Pro Glu Leu

420 425 430Leu Pro Ala Arg Thr Arg Gln Asn Ala Gln Gly Leu Val Asp Val Phe

435 440 445Pro Glu Tyr Phe Glu Glu Leu Asp Pro Val Gly Arg Val Leu Leu Pro

450 455 460Arg Ala Asp Ile Ala Thr Asp Val Leu Val Asp Gly Leu Thr His Leu465 470 475 480Gly Trp Glu Val Glu Asp Val Val Ala Tyr Arg Thr Val Arg Ala Ala

485 490 495Pro Pro Ser Ala Asp Ile Arg Asp Met Ile Lys Thr Gly Gly Phe Asp

500 505 510Ala Val Ala Phe Thr Ser Ser Ser Thr Val Lys Asn Leu Val Gly Ile

515 520 525Ala Gly Lys Pro His Pro Arg Thr Ile Val Ala Cys Ile Gly Pro Met

530 535 540Thr Ala Ala Thr Ala Glu Glu Leu Gly Leu Arg Val Asp Val Met Pro545 550 555 560Glu Ile Ala Glu Val Pro Glu Leu Ile Asp Ala Leu Ala Glu His Val

565 570 575Ala Asp Leu Arg Ala Lys Gly Glu Leu Pro Pro Pro Arg Lys Lys Arg

580 585 590Arg Arg Arg Lys Ala Ser

595<210>821<211>1024<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1024)<223>FRXA00371<400>821gtcgtggaca atcccggatc gaaaatttga ttcggctttt ttcatggctg ttgatggagt 60acgttggtcg ttttcgagac aagtactaga aaagatattg atg act atc gcc cat 115

Met Thr Ile Ala His

1 5aag ccc gag atg gct gaa act acc ggg atc gag acc aac cag gtt tcc 163Lys Pro Glu Met Ala Glu Thr Thr Gly Ile Glu Thr Asn Gln Val Ser

10 15 20gaa acc atc ggg gtt gaa tcg ctc acg cac gga aac tta cgt cct gtt 211Glu Thr Ile Gly Val Glu Ser Leu Thr His Gly Asn Leu Arg Pro Val

25 30 35tca tct ttt gag gga cag cat gag gga caa acg gaa gag tta ctt cca 259Ser Ser Phe Glu Gly Gln His Glu Gly Gln Thr Glu Glu Leu Leu Pro

40 45 50ggc aaa gtc att ttt gtt ggg gcc ggt ccc ggt aac cct gat ctt ctt 307Gly Lys Val Ile Phe Val Gly Ala Gly Pro Gly Asn Pro Asp Leu Leu

55 60 65aca gtt cgt gcc cgt gaa gtt ctg ggc aac gcg gtt cgt gcg att act 355Thr Val Arg Ala Arg Glu Val Leu Gly Asn Ala Val Arg Ala Ile Thr 70 75 80 85gat gaa caa gta cta agc ggc gtt cga gct ttt gtc gcc act gaa att 403Asp Glu Gln Val LeuSer Gly Val Arg Ala Phe Val Ala Thr Glu Ile

90 95 100cct gtg ccg gaa gat aag ctt cag gct gcg gaa gat gag tac gag cgc 451Pro Val Pro Glu Asp Lys Leu Gln Ala Ala Glu Asp Glu Tyr Glu Arg

105 110 115atc tgc att gaa gcg aag gag aac ggt gca cgc cgt aag cct cct cgt 499Ile Cys Ile Glu Ala Lys Glu Asn Gly Ala Arg Arg Lys Pro Pro Arg

120 125 130cca gca cca cca acc gct gca gag atc acg gaa gtt tct gag gcg act 547Pro Ala Pro Pro Thr Ala Ala Glu Ile Thr Glu Val Ser Glu Ala Thr

135 140 145cca gct cag att gtt gag ctt gtg cag gat gct ctt tct tat ggt gga 595Pro Ala Gln Ile Val Glu Leu Val Gln Asp Ala Leu Ser Tyr Gly Gly150 155 160 165gat gtt att cgt ctt gtc acc ggc aac cca ttg agc agc gat gcc aca 643Asp Val Ile Arg Leu Val Thr Gly Asn Pro Leu Ser Ser Asp Ala Thr

170 175 180ctg gct gag atc tct gca gtt tcc gag gct ggc ctg gag ttc cag gtg 691Leu Ala Glu Ile Ser Ala Val Ser Glu Ala Gly Leu Glu Phe Gln Val

185 190 195gtt cca ggt atg tct ttg cct gca acg gtt cct gca ttt gcg gga att 739Val Pro Gly Met Ser Leu Pro Ala Thr Val Pro Ala Phe Ala Gly Ile

200 205 210gcg ttg ggt tct acc tac acc gaa act gat gtc aac ggt caa aac ttg 787Ala Leu Gly Ser Thr Tyr Thr Glu Thr Asp Val Asn Gly Gln Asn Leu

215 220 225gac tgg gat cag ttg gct agc gca cct cag cct ttg gtg ctg cag gcc 835Asp Trp Asp Gln Leu Ala Ser Ala Pro Gln Pro Leu Val Leu Gln Ala230 235240 245cgc gtg gat gac ctt tcc cgt att gca cag gaa cta aag gcc cgc aat 883Arg Val Asp Asp Leu Ser Arg Ile Ala Gln Glu Leu Lys Ala Arg Asn

250 255 260atg tct ttg gaa act cct gtt tct gtc acc gct aac ggc acc acc cgt 931Met Ser Leu Glu Thr Pro Val Ser Val Thr Ala Asn Gly Thr Thr Arg

265 270 275ttg cag cgc acc tat gac acc act tta ggt ctg ttg cac aag ctt gat 979Leu Gln Arg Thr Tyr Asp Thr Thr Leu Gly Leu Leu His Lys Leu Asp

280 285 290gct gaa cta agc gga cct ttg gtt gtt acc ttg ggc aag ggt gtg 1024Ala Glu Leu Ser Gly Pro Leu Val Val Thr Leu Gly Lys Gly Val

295300305<210>822<211>308<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>822Met Thr Ile Ala His Lys Pro Glu Met Ala Glu Thr Thr Gly Ile Glu 151015 Thr Asn Gln Val Ser Glu Thr Ile Gly Val Glu Ser Leu Thr His Gly

20 25 30Asn Leu Arg Pro Val Ser Ser Phe Glu Gly Gln His Glu Gly Gln Thr

35 40 45Glu Glu Leu Leu Pro Gly Lys Val Ile Phe Val Gly Ala Gly Pro Gly

50 55 60Asn Pro Asp Leu Leu Thr Val Arg Ala Arg Glu Val Leu Gly Asn Ala 65 70 75 80Val Arg Ala Ile Thr Asp Glu Gln Val Leu Ser Gly Val Arg Ala Phe

85 90 95Val Ala Thr Glu Ile Pro Val Pro Glu Asp Lys Leu Gln Ala Ala Glu

100 105 110Asp Glu Tyr Glu Arg Ile Cys Ile Glu Ala Lys Glu Asn Gly Ala Arg

115 120 125Arg Lys Pro Pro Arg Pro Ala Pro Pro Thr Ala Ala Glu Ile Thr Glu

130 135 140Val Ser Glu Ala Thr Pro Ala Gln Ile Val Glu Leu Val Gln Asp Ala145 150 155 160Leu Ser Tyr Gly Gly Asp Val Ile Arg Leu Val Thr Gly Asn Pro Leu

165 170 175Ser Ser Asp Ala Thr Leu Ala Glu Ile Ser Ala Val Ser Glu Ala Gly

180 185 190Leu Glu Phe Gln Val Val Pro Gly Met Ser Leu Pro Ala Thr Val Pro

195 200 205Ala Phe Ala Gly Ile Ala Leu Gly Ser Thr Tyr Thr Glu Thr Asp Val

210 215 220Asn Gly Gln Asn Leu Asp Trp Asp Gln Leu Ala Ser Ala Pro Gln Pro225 230 235 240Leu Val Leu Gln Ala Arg Val Asp Asp Leu Ser Arg Ile Ala Gln Glu

245 250 255Leu Lys Ala Arg Asn Met Ser Leu Glu Thr Pro Val Ser Val Thr Ala

260 265 270Asn Gly Thr Thr Arg Leu Gln Arg Thr Tyr Asp Thr Thr Leu Gly Leu

275 280 285Leu His Lys Leu Asp Ala Glu Leu Ser Gly Pro Leu Val Val Thr Leu

290295300 Gly Lys Gly Val305<210>823<211>755<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (732)<223>FRXA00374<400>823acc att tct gtc gaa cca ccg cgc aac cca gcg caa atg gaa cgc gcc 48Thr Ile Ser Val Glu Pro Pro Arg Asn Pro Ala Gln Met Glu Arg Ala 151015 atc aag ggc atc gtc gaa gga cgc tac cag tgg gtt gtc ctc aca agc 96Ile Lys Gly Ile Val Glu Gly Arg Tyr Gln Trp Val Val Leu Thr Ser

20 25 30gtc aac gca gtg aag gca gtc tgg aag aaa atc acc gaa ttc ggc ctc 144Val Asn Ala Val Lys Ala Val Trp Lys Lys Ile Thr Glu Phe Gly Leu

35 40 45gat tca cgt tcc ttc gcg ggc gtc cgc atc gcc gca gtc ggt gaa aaa 192Asp Ser Arg Ser Phe Ala Gly Val Arg Ile Ala Ala Val Gly Glu Lys

50 55 60acc gcc gct gag atc cgc gcg ctc ggc atc acg ccg gag ctt ctg cct 240Thr Ala Ala Glu Ile Arg Ala Leu Gly Ile Thr Pro Glu Leu Leu Pro 65 70 75 80gca cgt acc agg caa aat gcg caa ggg ctt gtc gac gtg ttc ccc gaa 288Ala Arg Thr Arg Gln Asn Ala Gln Gly Leu Val Asp Val Phe Pro Glu

85 90 95tat ttc gaa gaa ctc gat cca gtc ggc cgt gtc ctc ttg ccg cgc gca 336Tyr Phe Glu Glu Leu Asp Pro Val Gly Arg Val Leu Leu Pro Arg Ala

100 105 110gat atc gca acc gac gtg ctt gtc gac ggc ctg acc cac ctt ggt tgg 384Asp Ile Ala Thr Asp Val Leu Val Asp Gly Leu Thr His Leu Gly Trp

115 120 125gaa gtc gaa gac gtg gtg gct tac cgc acc gtc cgc gca gca cca cca 432Glu Val Glu Asp Val Val Ala Tyr Arg Thr Val Arg Ala Ala Pro Pro

130 135 140agc gct gat atc cga gat atg atc aag acc ggc gga ttt gat gca gtt 480Ser Ala Asp Ile Arg Asp Met Ile Lys Thr Gly Gly Phe Asp Ala Val145 150 155 160gcc ttc acc tct tcg tcg acc gtg aag aac ctc gtt ggt atc gcg ggt 528Ala Phe Thr Ser Ser Ser Thr Val Lys Asn Leu Val Gly Ile Ala Gly

165 170 175aaa cca cac cca cgc acc atc gtc gcg tgc atc gga ccc atg act gca 576Lys Pro His Pro Arg Thr Ile Val Ala Cys Ile Gly Pro Met Thr Ala

180 185 190gcg acc gct gaa gaa ctg gga ctg cgc gtt gat gtc atg cca gag atc 624Ala Thr Ala Glu Glu Leu Gly Leu Arg Val Asp Val Met Pro Glu Ile

195 200 205gcc gaa gta cca gaa ctg atc gac gct ctt gcg gaa cac gtg gcg gat 672Ala Glu Val Pro Glu Leu Ile Asp Ala Leu Ala Glu His Val Ala Asp

210215220 ctg cgc gct aag ggc gag ctg ccg ccg ccg agg aag aaa cgc agg cgt 720Leu Arg Ala Lys Gly Glu Leu Pro Pro Pro Arg Lys Lys Arg Arg Arg 225230235240 cga aaa gcg tct taaaaggttt ttcactaggg tgt 755Arg Lys Ala Ser<210>824<211>244<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>824Thr Ile Ser Val Glu Pro Pro Arg Asn Pro Ala Gln Met Glu Arg Ala 151015 Ile Lys Gly Ile Val Glu Gly Arg Tyr Gln Trp Val Val Leu Thr Ser

20 25 30Val Asn Ala Val Lys Ala Val Trp Lys Lys Ile Thr Glu Phe Gly Leu

35 40 45Asp Ser Arg Ser Phe Ala Gly Val Arg Ile Ala Ala Val Gly Glu Lys

50 55 60Thr Ala Ala Glu Ile Arg Ala Leu Gly Ile Thr Pro Glu Leu Leu Pro 65 70 75 80Ala Arg Thr Arg Gln Asn Ala Gln Gly Leu Val Asp Val Phe Pro Glu

85 90 95Tyr Phe Glu Glu Leu Asp Pro Val Gly Arg Val Leu Leu Pro Arg Ala

100 105 110Asp Ile Ala Thr Asp Val Leu Val Asp GlyLeu Thr His Leu Gly Trp

115 120 125Glu Val Glu Asp Val Val Ala Tyr Arg Thr Val Arg Ala Ala Pro Pro

130 135 140Ser Ala Asp Ile Arg Asp Met Ile Lys Thr Gly Gly Phe Asp Ala Val145 150 155 160Ala Phe Thr Ser Ser Ser Thr Val Lys Asn Leu Val Gly Ile Ala Gly

165 170 175Lys Pro His Pro Arg Thr Ile Val Ala Cys Ile Gly Pro Met Thr Ala

180 185 190Ala Thr Ala Glu Glu Leu Gly Leu Arg Val Asp Val Met Pro Glu Ile

195 200 205Ala Glu Val Pro Glu Leu Ile Asp Ala Leu Ala Glu His Val Ala Asp

210215220 Leu Arg Ala Lys Gly Glu Leu Pro Pro Pro Arg Lys Lys Arg Arg Arg 225230235240 Arg Lys Ala Ser<210>825<211>1467<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1444)<223>RXN00383<400>825ccatatcttt aaccttggtc atggtgtgct tcctaatacg gtggcggaag atattactga 60agccgtctcc atcattcatt cttaaactaa gaggagtttc atg cgt ttt gcc atc 115

Met Arg Phe Ala Ile

1 5atc ggt gca ggc ctt gcg ggt ctg act gct gca tat gag atc cat aaa 163Ile Gly Ala Gly Leu Ala Gly Leu Thr Ala Ala Tyr Glu Ile His Lys

10 15 20gct gat ccc act gcc caa atc gat gtg ttg gaa gca ggc gaa cgc att 211Ala Asp Pro Thr Ala Gln Ile Asp Val Leu Glu Ala Gly Glu Arg Ile

25 30 35ggc ggcaag ctt ttt acg gtg ccg ttt gct tcc gga cct acc gat att 259Gly Gly Lys Leu Phe Thr Val Pro Phe Ala Ser Gly Pro Thr Asp Ile

40 45 50gga gcg gag gcg ttt tta gct gcg cgt tcc gat gcg gtg gag ttt ttt 307Gly Ala Glu Ala Phe Leu Ala Ala Arg Ser Asp Ala Val Glu Phe Phe

55 60 65act gag ctt ggg ttg gct gat tct ttg gtc agc ccg tct gct gcg aag 355Thr Glu Leu Gly Leu Ala Asp Ser Leu Val Ser Pro Ser Ala Ala Lys 70 75 80 85tct cag tat ttc gcg ggc ggt gcg ctg cat gcg ttc ccc gca ggt gga 403Ser Gln Tyr Phe Ala Gly Gly Ala Leu His Ala Phe Pro Ala Gly Gly

90 95 100gtg atg ggt att cca agc aat cca cca gca ggc gcg caa gac acc gct 451Val Met Gly Ile Pro Ser Asn Pro Pro Ala Gly Ala Gln Asp Thr Ala

105 110 115ttt gat tgg act cct ggc caa gac att tct gtt ggc gcc tta gtg cgc 499Phe Asp Trp Thr Pro Gly Gln Asp Ile Ser Val Gly Ala Leu Val Arg

120 125 130cgt cag tat ggc gat gag atc gtc gat act gtg gtg tct tcg ctg ctt 547Arg Gln Tyr Gly Asp Glu Ile Val Asp Thr Val Val Ser Ser Leu Leu

135 140 145ggt ggc gtt tat tcc tcc acc gct gat gat ctg ggt gtg cgc gct tcc 595Gly Gly Val Tyr Ser Ser Thr Ala Asp Asp Leu Gly Val Arg Ala Ser150 155 160 165gtg ccg gca ctt gct gca gcc ctt gat cag ctg gct gag gcc ggc gag 643Val Pro Ala Leu Ala Ala Ala Leu Asp Gln Leu Ala Glu Ala Gly Glu

170 175 180ccg gtg act ctg tca gct gcg gtc aag gcc gtg gaa gct cag cgg gaa 691Pro Val Thr Leu Ser Ala Ala Val Lys AlaVal Glu Ala Gln Arg Glu

185 190 195gcc gca aaa aca act tca gaa acc cgc ccc gtt ttc cag acc ttc aag 739Ala Ala Lys Thr Thr Ser Glu Thr Arg Pro Val Phe Gln Thr Phe Lys

200 205 210ggc gga tac gcg gag ctg tac gaa gcg ttg gca gag caa tgc ggt gca 787Gly Gly Tyr Ala Glu Leu Tyr Glu Ala Leu Ala Glu Gln Cys Gly Ala

215 220 225gat att cac ttg gat agt ttc gtt tcc gcc atc acc aaa gat ggt gaa 835Asp Ile His Leu Asp Ser Phe Val Ser Ala Ile Thr Lys Asp Gly Glu230 235 240 245ggt ttt gcc atc aag ggc ggt ggc gaa ggc acc tac gac aag gtg att 883Gly Phe Ala Ile Lys Gly Gly Gly Glu Gly Thr Tyr Asp Lys Val Ile

250 255 260ttg gcg gtt ccc gct cca acc gcc gct gtg ctg ctc cgc gac ttg gca 931Leu Ala Val Pro Ala Pro Thr Ala Ala Val Leu Leu Arg Asp Leu Ala

265 270 275ccg gcc gca gcg cca cat ttg cgc gca att aag ttg gct tct tca gca 979Pro Ala Ala Ala Pro His Leu Arg Ala Ile Lys Leu Ala Ser Ser Ala

280 285 290gtc gtc ggc atg cgt ttc gat tcc agc gag ggc ctg ccc gac aac tcc 1027Val Val Gly Met Arg Phe Asp Ser Ser Glu Gly Leu Pro Asp Asn Ser

295 300 305ggc gtc ctg gtc gct gtt aat gag ccg ggc atc acg gcg aag gcc ttc 1075Gly Val Leu Val Ala Val Asn Glu Pro Gly Ile Thr Ala Lys Ala Phe310 315 320 325acg ttc tcc tca aag aag tgg cct cac ctg gag gct cgc ggg ggc gcg 1123Thr Phe Ser Ser Lys Lys Trp Pro His Leu Glu Ala Arg Gly Gly Ala

330 335340ctc gtg cgc gcg tcg ttc ggc agg cta ggc gat gag gcg tcg gca cgc 1171Leu Val Arg Ala Ser Phe Gly Arg Leu Gly Asp Glu Ala Ser Ala Arg

345 350 355atg gac gag gat ttg ctt gtc gac gcc gcc ctc gac gat ctc ctc acc 1219Met Asp Glu Asp Leu Leu Val Asp Ala Ala Leu Asp Asp Leu Leu Thr

360 365 370ata acc ggg ttc gac ggc cgg gct gcc gga ctg ggt gaa att ttc gtg 1267Ile Thr Gly Phe Asp Gly Arg Ala Ala Gly Leu Gly Glu Ile Phe Val

375 380 385cag cgc tgg ttc ggt ggg ctc cca gcc tat gga gtt gat cac att gct 1315Gln Arg Trp Phe Gly Gly Leu Pro Ala Tyr Gly Val Asp His Ile Ala390 395 400 405acc gtt tcg gct gcg cgt gca gag atc gca gcc gtg cct ggc gtg gaa 1363Thr Val Ser Ala Ala Arg Ala Glu Ile Ala Ala Val Pro Gly Val Glu

410 415 420gca att ggc gcg tgg gct ggg gga gtg gga gtt ccc gca gtt atc gca 1411Ala Ile Gly Ala Trp Ala Gly Gly Val Gly Val Pro Ala Val Ile Ala

425 430 435gat gcc cag gca gca gta cac agg ttg ctg gga taagcaccca aaaacactat 1464Asp Ala Gln Ala Ala Val His Arg Leu Leu Gly

440445 tga 1467<210>826<211>448<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>826Met Arg Phe Ala Ile Ile Gly Ala Gly Leu Ala Gly Leu Thr Ala Ala 151015 Tyr Glu Ile His Lys Ala Asp Pro Thr Ala Gln Ile Asp Val Leu Glu

20 25 30Ala Gly Glu Arg Ile Gly Gly Lys Leu Phe Thr Val Pro Phe Ala Ser

35 40 45Gly Pro Thr Asp Ile Gly Ala Glu Ala Phe Leu Ala Ala Arg Ser Asp

50 55 60Ala Val Glu Phe Phe Thr Glu Leu Gly Leu Ala Asp Ser Leu Val Ser 65 70 75 80Pro Ser Ala Ala Lys Ser Gln Tyr Phe Ala Gly Gly Ala Leu His Ala

85 90 95Phe Pro Ala Gly Gly Val Met Gly Ile Pro Ser Asn Pro Pro Ala Gly

100 105 110Ala Gln Asp Thr Ala Phe Asp Trp Thr Pro Gly Gln Asp Ile Ser Val

115 120 125Gly Ala Leu Val Arg Arg Gln Tyr Gly Asp Glu Ile Val Asp Thr Val

130 135 140Val Ser Ser Leu Leu Gly Gly Val Tyr Ser Ser Thr Ala Asp Asp Leu145 150 155 160Gly Val Arg Ala Ser Val Pro Ala Leu Ala Ala Ala Leu Asp Gln Leu

165 170 175Ala Glu Ala Gly Glu Pro Val Thr Leu Ser Ala Ala Val Lys Ala Val

180 185 190Glu Ala Gln Arg Glu Ala Ala Lys Thr Thr Ser Glu Thr Arg Pro Val

195 200 205Phe Gln Thr Phe Lys Gly Gly Tyr Ala Glu Leu Tyr Glu Ala Leu Ala

210 215 220Glu Gln Cys Gly Ala Asp Ile His Leu Asp Ser Phe Val Ser Ala Ile225 230 235 240Thr Lys Asp Gly Glu Gly Phe Ala Ile Lys Gly Gly Gly Glu Gly Thr

245 250 255Tyr Asp Lys Val Ile Leu Ala Val Pro Ala Pro Thr Ala Ala Val Leu

260 265 270Leu Arg Asp Leu Ala Pro Ala Ala Ala Pro His Leu Arg Ala Ile Lys

275 280 285Leu Ala Ser Ser Ala Val Val Gly Met Arg Phe Asp Ser Ser Glu Gly

290 295 300Leu Pro Asp Asn Ser Gly Val Leu Val Ala Val Asn Glu Pro Gly Ile305 310 315 320Thr Ala Lys Ala Phe Thr Phe Ser Ser Lys Lys Trp Pro His Leu Glu

325 330 335Ala Arg Gly Gly Ala Leu Val Arg Ala Ser Phe Gly Arg Leu Gly Asp

340 345 350Glu Ala Ser Ala Arg Met Asp Glu Asp Leu Leu Val Asp Ala Ala Leu

355 360 365Asp Asp Leu Leu Thr Ile Thr Gly Phe Asp Gly Arg Ala Ala Gly Leu

370 375 380Gly Glu Ile Phe Val Gln Arg Trp Phe Gly Gly Leu Pro Ala Tyr Gly385 390 395 400Val Asp His Ile Ala Thr Val Ser Ala Ala Arg Ala Glu Ile Ala Ala

405 410 415Val Pro Gly Val Glu Ala Ile Gly Ala Trp Ala Gly Gly Val Gly Val

420 425 430Pro Ala Val Ile Ala Asp Ala Gln Ala Ala Val His Arg Leu Leu Gly

435440445<210>827<211>382<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (382)<223>FRXA00376<400>827ccatatcttt aaccttggtc atggtgtgct tcctaatacg gtggcggaag atattactga 60agccgtctcc atcattcatt cttaaactaa gaggagtttc atg cgt ttt gcc atc 115

Met Arg Phe Ala Ile

1 5atc ggt gca ggc ctt gcg ggt ctg act gct gca tat gag atc cat aaa 163Ile Gly Ala Gly Leu Ala Gly Leu Thr Ala Ala Tyr Glu Ile His Lys

10 15 20gct gat ccc act gcc caa atc gat gtg ttg gaa gca ggc gaa cgc att 211Ala Asp Pro Thr Ala Gln Ile Asp Val Leu Glu Ala Gly Glu Arg Ile

25 30 35ggc ggc aag ctt ttt acg gtg ccg ttt gct tcc gga cct acc gat att 259Gly Gly Lys Leu Phe Thr Val Pro Phe Ala Ser Gly Pro Thr Asp Ile

40 45 50gga gcg gag gcg ttt tta gct gcg cgt tcc gat gcg gtg gag ttt ttt 307Gly Ala Glu Ala Phe Leu Ala Ala Arg Ser Asp Ala Val Glu Phe Phe

55 60 65act gag ctt ggg ttg gct gat tct ttg gtc agc ccg tct gct gcg aag 355Thr Glu Leu Gly Leu Ala Asp Ser Leu Val Ser Pro Ser Ala Ala Lys 70 75 80 85tct cag tat ttc gcg ggc ggt gcg ctg 382Ser Gln Tyr Phe Ala Gly Gly Ala Leu

90<210>828<211>94<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>828Met Arg Phe Ala Ile Ile Gly Ala Gly Leu Ala Gly Leu Thr Ala Ala 151015 Tyr Glu Ile His Lys Ala Asp Pro Thr Ala Gln Ile Asp Val Leu Glu

20 25 30Ala Gly Glu Arg Ile Gly Gly Lys Leu Phe Thr Val Pro Phe Ala Ser

35 40 45Gly Pro Thr Asp Ile Gly Ala Glu Ala Phe Leu Ala Ala Arg Ser Asp

50 55 60Ala Val Glu Phe Phe Thr Glu Leu Gly Leu Ala Asp Ser Leu Val Ser 65 70 7580Pro Ser Ala Ala Lys Ser Gln Tyr Phe Ala Gly Gly Ala Leu

8590<210>829<211>1037<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1).<1014)<223>FRXA00383<400>829gca ggc gcg caa gac acc gct ttt gat tgg act cct ggc caa gac att 48Ala Gly Ala Gln Asp Thr Ala Phe Asp Trp Thr Pro Gly Gln Asp Ile 151015 tct gtt ggc gcc tta gtg cgc cgt cag tat ggc gat gag atc gtc gat 96Ser Val Gly Ala Leu Val Arg Arg Gln Tyr Gly Asp Glu Ile Val Asp

20 25 30act gtg gtg tct tcg ctg ctt ggt ggc gtt tat tcc tcc acc gct gat 144Thr Val Val Ser Ser Leu Leu Gly Gly Val Tyr Ser Ser Thr Ala Asp

35 40 45gat ctg ggt gtg cgc gct tcc gtg ccg gca ctt gct gca gcc ctt gat 192Asp Leu Gly Val Arg Ala Ser Val Pro Ala Leu Ala Ala Ala Leu Asp

50 55 60cag ctg gct gag gcc ggc gag ccg gtg act ctg tca gct gcg gtc aag 240Gln Leu Ala Glu Ala Gly Glu Pro Val Thr Leu Ser Ala Ala Val Lys 65 70 75 80gcc gtg gaa gct cag cgg gaa gcc gca aaa aca act tca gaa acc cgc 288Ala Val Glu Ala Gln Arg Glu Ala Ala Lys Thr Thr Ser Glu Thr Arg

85 90 95ccc gtt ttc cag acc ttc aag ggc gga tac gcg gag ctg tac gaa gcg 336Pro Val Phe Gln Thr Phe Lys Gly Gly Tyr Ala Glu Leu Tyr Glu Ala

100 105 110ttg gca gag caa tgc ggt gca gat att cac ttg gat agt ttc gtt tcc 384Leu Ala Glu Gln Cys Gly Ala Asp Ile His Leu Asp Ser Phe Val Ser

115 120 125gcc atc acc aaa gat ggt gaa ggt ttt gcc atc aag ggc ggt ggc gaa 432Ala Ile Thr Lys Asp Gly Glu Gly Phe Ala Ile Lys Gly Gly Gly Glu

130 135 140ggc acc tac gac aag gtg att ttg gcg gtt ccc gct cca acc gcc gct 480Gly Thr Tyr Asp Lys Val Ile Leu Ala Val Pro Ala Pro Thr Ala Ala145 150 155 160gtg ctg ctc cgc gac ttg gca ccg gcc gca gcg cca cat ttg cgc gca 528Val Leu Leu Arg Asp Leu Ala Pro Ala Ala Ala Pro His Leu Arg Ala

165 170 175att aag ttg gct tct tca gca gtc gtc ggc atg cgt ttc gat tcc agc 576Ile Lys Leu Ala Ser Ser Ala Val Val Gly Met Arg Phe Asp Ser Ser

180 185 190gag ggc ctg ccc gac aac tcc ggc gtc ctg gtc gct gtt aat gag ccg 624Glu Gly Leu Pro Asp Asn Ser Gly Val Leu Val Ala Val Asn Glu Pro

195 200 205ggc atc acg gcg aag gcc ttc acg ttc tcc tca aag aag tgg cct cac 672Gly Ile Thr Ala Lys Ala Phe Thr Phe Ser Ser Lys Lys Trp Pro His

210 215 220ctg gag gct cgc ggg ggc gcg ctc gtg cgc gcg tcg ttc ggc agg cta 720Leu Glu Ala Arg Gly Gly Ala Leu Val Arg Ala Ser Phe Gly Arg Leu225 230 235 240ggc gat gag gcg tcg gca cgc atg gac gag gat ttg ctt gtc gac gcc 768Gly Asp Glu Ala Ser Ala Arg Met Asp Glu Asp Leu Leu Val Asp Ala

245 250 255gcc ctc gac gat ctc ctc acc ata acc ggg ttc gac ggc cgg gct gcc 816Ala Leu Asp Asp Leu Leu Thr Ile Thr Gly Phe Asp Gly Arg Ala Ala

260 265 270gga ctg ggt gaa att ttc gtg cag cgc tgg ttc ggt ggg ctc cca gcc 864Gly Leu Gly Glu Ile Phe Val Gln Arg Trp Phe Gly Gly Leu Pro Ala

275 280 285tat gga gtt gat cac att gct acc gtt tcg gct gcg cgt gca gag atc 912Tyr Gly Val Asp His Ile Ala Thr Val Ser Ala Ala Arg Ala Glu Ile

290 295 300gca gcc gtg cct ggc gtg gaa gca att ggc gcg tgg gct ggg gga gtg 960Ala Ala Val Pro Gly Val Glu Ala Ile Gly Ala Trp Ala Gly Gly Val305 310 315 320gga gtt ccc gca gtt atc gca gat gcc cag gca gca gta cac agg ttg 1008Gly Val Pro Ala Val Ile Ala Asp Ala Gln Ala Ala Val His Arg Leu

325330335 ctg gga taagcaccca aaaacactat tga 1037Leu Gly<210>830<211>338<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>830Ala Gly Ala Gln Asp Thr Ala Phe Asp Trp Thr Pro Gly Gln Asp Ile 151015 Ser Val Gly Ala Leu Val Arg Arg Gln Tyr Gly Asp Glu Ile Val Asp

20 25 30Thr Val Val Ser Ser Leu Leu Gly Gly Val Tyr Ser Ser Thr Ala Asp

35 40 45Asp Leu Gly Val Arg Ala Ser Val Pro Ala Leu Ala Ala Ala Leu Asp

50 55 60Gln Leu Ala Glu Ala Gly Glu Pro Val Thr Leu Ser Ala Ala Val Lys 65 70 75 80Ala Val Glu Ala Gln Arg Glu Ala Ala Lys Thr Thr Ser Glu Thr Arg

85 90 95Pro Val Phe Gln Thr Phe Lys Gly Gly Tyr Ala Glu Leu Tyr Glu Ala

100 105 110Leu Ala Glu Gln Cys Gly Ala Asp Ile His Leu Asp Ser Phe Val Ser

115 120 125Ala Ile Thr Lys Asp Gly Glu Gly Phe Ala Ile Lys Gly Gly Gly Glu

130135 140Gly Thr Tyr Asp Lys Val Ile Leu Ala Val Pro Ala Pro Thr Ala Ala145 150 155 160Val Leu Leu Arg Asp Leu Ala Pro Ala Ala Ala Pro His Leu Arg Ala

165 170 175Ile Lys Leu Ala Ser Ser Ala Val Val Gly Met Arg Phe Asp Ser Ser

180 185 190Glu Gly Leu Pro Asp Asn Ser Gly Val Leu Val Ala Val Asn Glu Pro

195 200 205Gly Ile Thr Ala Lys Ala Phe Thr Phe Ser Ser Lys Lys Trp Pro His

210 215 220Leu Glu Ala Arg Gly Gly Ala Leu Val Arg Ala Ser Phe Gly Arg Leu225 230 235 240Gly Asp Glu Ala Ser Ala Arg Met Asp Glu Asp Leu Leu Val Asp Ala

245 250 255Ala Leu Asp Asp Leu Leu Thr Ile Thr Gly Phe Asp Gly Arg Ala Ala

260 265 270Gly Leu Gly Glu Ile Phe Val Gln Arg Trp Phe Gly Gly Leu Pro Ala

275 280 285Tyr Gly Val Asp His Ile Ala Thr Val Ser Ala Ala Arg Ala Glu Ile

290 295 300Ala Ala Val Pro Gly Val Glu Ala Ile Gly Ala Trp Ala Gly Gly Val305 310 315 320Gly Val Pro Ala Val Ile Ala Asp Ala Gln Ala Ala Val His Arg Leu

325330335 Leu Gly<210>831<211>873<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (850)<223>RXA01253<400>831acgccatcgc agcctgccct cctggccgca tcgaagtcct cgccaactac accgcattcc 60gagacctcaa aaaggctctg gagaaaggga ccgaacaata atg acc acc ctc aac 115

Met Thr Thr Leu Asn

1 5atc ggc ctc atc ctc ccc gac gtc ctc gga act tac ggc gac gac ggc 163Ile Gly Leu Ile Leu Pro Asp Val Leu Gly Thr Tyr Gly Asp Asp Gly

10 15 20aac gca cta gtc ctg cgc caa cgc gca cgc atg cgt ggc att aat gct 211Asn Ala Leu Val Leu Arg Gln Arg Ala Arg Met Arg Gly Ile Asn Ala

25 30 35gaa atc cag cgc gtc acc ctc gac gac gcc gtc cct tcc acc ctt gat 259Glu Ile Gln Arg Val Thr Leu Asp Asp Ala Val Pro Ser Thr Leu Asp

40 45 50ctc tac tgc ctc ggc ggc ggc gag gac acc gca cag atc ctt gcc acc 307Leu Tyr Cys Leu Gly Gly Gly Glu Asp Thr Ala Gln Ile Leu Ala Thr

55 60 65gaa cac ctc acc aaa gac ggc ggc ctc caa acc gca gcc gcc gca ggc 355Glu His Leu Thr Lys Asp Gly Gly Leu Gln Thr Ala Ala Ala Ala Gly 70 75 80 85cgc ccc atc ttc gca gtc tgc gca ggt ctc cag gta ctc ggc gac tcc 403Arg Pro Ile Phe Ala Val Cys Ala Gly Leu Gln Val Leu Gly Asp Ser

90 95 100ttc cgc gcc gcc ggc cgt gtc atc gac ggc ctt ggg ctt atc gac gcc 451Phe Arg Ala Ala Gly Arg Val Ile Asp Gly Leu Gly Leu Ile Asp Ala

105 110 115acc acc gtc tct tta caa aaa cgc gcc atc gga gaa gtc gaa acg aca 499Thr Thr Val Ser Leu Gln Lys Arg Ala Ile Gly Glu Val Glu Thr Thr

120 125 130cca acc cgc gcc gga ttc acc gcc gag ctg acc gaa cga ctc acc ggc 547Pro Thr Arg Ala Gly Phe Thr Ala Glu Leu Thr Glu Arg Leu Thr Gly

135 140 145ttc gaa aac cac atg ggc gcc acc ctg ctc ggc ccc gac gcc gaa cca 595Phe Glu Asn His Met Gly Ala Thr Leu Leu Gly Pro Asp Ala Glu Pro150 155 160 165ctc ggc cga gtc gtc cgc ggc gaa ggc aac acc gat gtc tgg gca gcc 643Leu Gly Arg Val Val Arg Gly Glu Gly Asn Thr Asp Val Trp Ala Ala

170 175 180tcc gaa aac acc gac gac caa cgc caa caa ttc gcc gaa ggc gcc gtc 691Ser Glu Asn Thr Asp Asp Gln Arg Gln Gln Phe Ala Glu Gly Ala Val

185 190 195caa ggc agc atc atc gcc acc tac atg cac ggc ccc gca ctc gcc cga 739Gln Gly Ser Ile Ile Ala Thr Tyr Met His Gly Pro Ala Leu Ala Arg

200 205 210aac ccc caa ctc gcc gac ctc atg ctc gca aaa gca atg ggt gtc gcg 787Asn Pro Gln Leu Ala Asp Leu Met Leu Ala Lys Ala Met Gly Val Ala

215 220 225ctg aaa gac ctg gag cct ttg gac atc gac gtc atc gac cgc ctc cgc 835Leu Lys Asp Leu Glu Pro Leu Asp Ile Asp Val Ile Asp Arg Leu Arg230 235 240 245gcc gaa cgc ctg gcg tagccccttc taaaccgggt cta 873Ala Glu Arg Leu Ala

250<210>832<211>250<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>832Met Thr Thr Leu Asn Ile Gly Leu Ile Leu Pro Asp Val Leu Gly Thr 151015 Tyr Gly Asp Asp Gly Asn Ala Leu Val Leu Arg Gln Arg Ala Arg Met

20 25 30Arg Gly Ile Asn Ala Glu Ile Gln Arg Val Thr Leu Asp Asp Ala Val

3540 45Pro Ser Thr Leu Asp Leu Tyr Cys Leu Gly Gly Gly Glu Asp Thr Ala

50 55 60Gln Ile Leu Ala Thr Glu His Leu Thr Lys Asp Gly Gly Leu Gln Thr 65 70 75 80Ala Ala Ala Ala Gly Arg Pro Ile Phe Ala Val Cys Ala Gly Leu Gln

85 90 95Val Leu Gly Asp Ser Phe Arg Ala Ala Gly Arg Val Ile Asp Gly Leu

100 105 110Gly Leu Ile Asp Ala Thr Thr Val Ser Leu Gln Lys Arg Ala Ile Gly

115 120 125Glu Val Glu Thr Thr Pro Thr Arg Ala Gly Phe Thr Ala Glu Leu Thr

130 135 140Glu Arg Leu Thr Gly Phe Glu Asn His Met Gly Ala Thr Leu Leu Gly145 150 155 160Pro Asp Ala Glu Pro Leu Gly Arg Val Val Arg Gly Glu Gly Asn Thr

165 170 175Asp Val Trp Ala Ala Ser Glu Asn Thr Asp Asp Gln Arg Gln Gln Phe

180 185 190Ala Glu Gly Ala Val Gln Gly Ser Ile Ile Ala Thr Tyr Met His Gly

195 200 205Pro Ala Leu Ala Arg Asn Pro Gln Leu Ala Asp Leu Met Leu Ala Lys

210 215 220Ala Met Gly Val Ala Leu Lys Asp Leu Glu Pro Leu Asp Ile Asp Val225 230 235 240Ile Asp Arg Leu Arg Ala Glu Arg Leu Ala

245250<210>833<211>1044<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1021)<223>RXA02134<400>833tgatgaacga catgtcgaca ttttcttccg ccggcgtcga tggaccccta aacgcctctt 60ccgaagcgcc cgagcaaaac acggagtaac tttctaagcg atg tcc ggc aaa gca 115

Met Ser Gly Lys Ala

1 5ggc ttt acc ccc gaa gat ccc gaa gac tca gac aac cgc cac ggg aac 163Gly Phe Thr Pro Glu Asp Pro Glu Asp Ser Asp Asn Arg His Gly Asn

10 15 20ccc ctt ttc gaa ggt atc ttt acc gca ctt aat tgg atg acc gtt ctc 211Pro Leu Phe Glu Gly Ile Phe Thr Ala Leu Asn Trp Met Thr Val Leu

25 30 35ccc gtc ccc ggc gca tca gtt ttt gat cgc acc acg ggc gcc cgg gta 259Pro Val Pro Gly Ala Ser Val Phe Asp Arg Thr Thr Gly Ala Arg Val

40 45 50atg gcc tct ttg ccc ttt gtt ggc ttc gtt ttc gga atg ttc acc gcg 307Met Ala Ser Leu Pro Phe Val Gly Phe Val Phe Gly Met Phe Thr Ala

55 60 65atc atc atg tgg gct atc ggc ccc att tca ggg gtg atc cac gtc gat 355Ile Ile Met Trp Ala Ile Gly Pro Ile Ser Gly Val Ile His Val Asp 70 75 80 85gga ctt tta gtt gcc gtt ctg atc gtc gcg ttc tgg gaa ctt ctt aat 403Gly Leu Leu Val Ala Val Leu Ile Val Ala Phe Trp Glu Leu Leu Asn

90 95 100cgg ttt atg cac ctc gac ggc ctc gca gat gtc tcc gat gct ttg ggt 451Arg Phe Met His Leu Asp Gly Leu Ala Asp Val Ser Asp Ala Leu Gly

105 110 115tcc tac gca gcc cca cca cgc gca cga gaa atc ctt gcc gat ccc cgc 499Ser Tyr Ala Ala Pro Pro Arg Ala Arg Glu Ile Leu Ala Asp Pro Arg

120 125 130acc gga ctt ttc ggc ctc gcc acc gcc atg ctt tcc gtt ctc ctg cag 547Thr Gly Leu Phe Gly Leu Ala Thr Ala Met Leu Ser Val Leu Leu Gln

135 140 145gtc gct gca gtc gca tcg ctt gtc gat tca acc gtg tgg tgg atg atc 595Val Ala Ala Val Ala Ser Leu Val Asp Ser Thr Val Trp Trp Met Ile150 155 160 165tgc ttc atc ccc gtt ctc ggc cgc atc gct gga caa gta acc gca ctg 643Cys Phe Ile Pro Val Leu Gly Arg Ile Ala Gly Gln Val Thr Ala Leu

170 175 180aaa aac cac aac gcc ttc tcc ccc acc ggc ttt ggc gca cta gtc atc 691Lys Asn His Asn Ala Phe Ser Pro Thr Gly Phe Gly Ala Leu Val Ile

185 190 195gga acg gtg aaa ttt tgg tgg atc gcg ctg tgg ctc ttg gtt act gct 739Gly Thr Val Lys Phe Trp Trp Ile Ala Leu Trp Leu Leu Val Thr Ala

200 205 210gcg ttg gct ttt tgg tgc gca gaa tta att tct cca ctt tca ccg ctg 787Ala Leu Ala Phe Trp Cys Ala Glu Leu Ile Ser Pro Leu Ser Pro Leu

215 220 225acc agt gtt aac act ccc ttt gtc gct gga cct ttc ccc gct gca atc 835Thr Ser Val Asn Thr Pro Phe Val Ala Gly Pro Phe Pro Ala Ala Ile230 235 240 245aac ccc gcc tgg ctt gga ggc tgg gtt gcg ata acc gca gtc gtg gca 883Asn Pro Ala Trp Leu Gly Gly Trp Val Ala Ile Thr Ala Val Val Ala

250 255 260tgt gtt ttc gca gca ctt ttc agc cgc cgc tta tca cga agt ttc ggt 931Cys Val Phe Ala Ala Leu Phe Ser Arg Arg Leu Ser Arg Ser Phe Gly

265 270 275gga ctc aac gga gac tgc atc ggc gca tgc att cat ctc ggg gcg tcg 979Gly Leu Asn Gly Asp Cys Ile Gly Ala Cys Ile His Leu Gly Ala Ser

280 285 290att tct gca gtg atg ttt gct gtt gtc gcc aat gca atg gtg 1021Ile Ser Ala Val Met Phe Ala Val Val Ala Asn Ala Met Val

295300305 taaagcggtg gcgtcttttg gga 1044<210>834<211>307<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>834Met Ser Gly Lys Ala Gly Phe Thr Pro Glu Asp Pro Glu Asp Ser Asp 151015 Asn Arg His Gly Asn Pro Leu Phe Glu Gly Ile Phe Thr Ala Leu Asn

20 25 30Trp Met Thr Val Leu Pro Val Pro Gly Ala Ser Val Phe Asp Arg Thr

35 40 45Thr Gly Ala Arg Val Met Ala Ser Leu Pro Phe Val Gly Phe Val Phe

50 55 60Gly Met Phe Thr Ala Ile Ile Met Trp Ala Ile Gly Pro Ile Ser Gly 65 70 75 80Val Ile His Val Asp Gly Leu Leu Val Ala Val Leu Ile Val Ala Phe

85 90 95Trp Glu Leu Leu Asn Arg Phe Met His Leu Asp Gly Leu Ala Asp Val

100 105 110Ser Asp Ala Leu Gly Ser Tyr Ala Ala Pro Pro Arg Ala Arg Glu Ile

115 120 125Leu Ala Asp Pro Arg Thr Gly Leu Phe Gly Leu Ala Thr Ala Met Leu

130 135 140Ser Val Leu Leu Gln Val Ala Ala Val Ala Ser Leu Val Asp Ser Thr145 150 155 160Val Trp Trp Met Ile Cys Phe Ile Pro Val Leu Gly Arg Ile Ala Gly

165 170175Gln Val Thr Ala Leu Lys Asn His Asn Ala Phe Ser Pro Thr Gly Phe

180 185 190Gly Ala Leu Val Ile Gly Thr Val Lys Phe Trp Trp Ile Ala Leu Trp

195 200 205Leu Leu Val Thr Ala Ala Leu Ala Phe Trp Cys Ala Glu Leu Ile Ser

210 215 220Pro Leu Ser Pro Leu Thr Ser Val Asn Thr Pro Phe Val Ala Gly Pro225 230 235 240Phe Pro Ala Ala Ile Asn Pro Ala Trp Leu Gly Gly Trp Val Ala Ile

245 250 255Thr Ala Val Val Ala Cys Val Phe Ala Ala Leu Phe Ser Arg Arg Leu

260 265 270Ser Arg Ser Phe Gly Gly Leu Asn Gly Asp Cys Ile Gly Ala Cys Ile

275 280 285His Leu Gly Ala Ser Ile Ser Ala Val Met Phe Ala Val Val Ala Asn

290295300 Ala Met Val305<210>835<211>1197<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1174)<223>RXA02135<400>835cgtgtcgcag cgatttgcga gagggttgtc ttcgtggttg ctggtctgcc actagagttg 60aaaacgtttt aagaaaacag tcggtttgaa ggagttgtta atg gtt cca gca gag 115

Met Val Pro Ala Glu

1 5ctt ttt gcg cgt gtg gaa ttt ccg gat cat aaa atc ctg gct cag acg 163Leu Phe Ala Arg Val Glu Phe Pro Asp His Lys Ile Leu Ala Gln Thr

10 15 20aag gat ttc cat gac tcc ctc acc aag cca ccc gga tct ttg ggc aag211Lys Asp Phe His Asp Ser Leu Thr Lys Pro Pro Gly Ser Leu Gly Lys

25 30 35ttg gag cag atc ggc tgt ttc att tcc gca tgc cag ggc cag att ccg 259Leu Glu Gln Ile Gly Cys Phe Ile Ser Ala Cys Gln Gly Gln Ile Pro

40 45 50cca cgt cca ctc aac aac tca aag atc gtt gtt ttc gct ggc gat cac 307Pro Arg Pro Leu Asn Asn Ser Lys Ile Val Val Phe Ala Gly Asp His

55 60 65ggc gtt gca act aaa ggc gtg tcc gcg tac cca tcc tca gta agc ttg 355Gly Val Ala Thr Lys Gly Val Ser Ala Tyr Pro Ser Ser Val Ser Leu 70 75 80 85cag atg gct gaa aac att aca aac ggt ggc gcc gcc atc aac gtg att 403Gln Met Ala Glu Asn Ile Thr Asn Gly Gly Ala Ala Ile Asn Val Ile

90 95 100gca cgc acc acc ggc acg tcc gtc cga ctt att gat acc tcc ctc gac 451Ala Arg Thr Thr Gly Thr Ser Val Arg Leu Ile Asp Thr Ser Leu Asp

105 110 115cac gaa gca tgg ggc gac gag cgc gta tct agg tcc tgc gga tcc atc 499His Glu Ala Trp Gly Asp Glu Arg Val Ser Arg Ser Cys Gly Ser Ile

120 125 130gat gtt gaa gac gcc atg acc caa gaa cag gtc gaa cgc gca ctg aag 547Asp Val Glu Asp Ala Met Thr Gln Glu Gln Val Glu Arg Ala Leu Lys

135 140 145atc ggt aag cgc att gcg gat caa gaa gtg gac gca ggc gcc gac att 595Ile Gly Lys Arg Ile Ala Asp Gln Glu Val Asp Ala Gly Ala Asp Ile150 155 160 165tta atc ccc ggc gat tta gga att ggc aac acc acc acc gcc gct gcc 643Leu Ile Pro Gly Asp Leu Gly Ile Gly Asn Thr Thr Thr Ala Ala Ala

170175 180ctc gtt gga acg ttc acc ctc gca gag cct gtt gtt gtc gta ggc cgc 691Leu Val Gly Thr Phe Thr Leu Ala Glu Pro Val Val Val Val Gly Arg

185 190 195ggc acc gga atc gac gat gaa gcc tgg aaa ctc aaa gtc tcc gcg atc 739Gly Thr Gly Ile Asp Asp Glu Ala Trp Lys Leu Lys Val Ser Ala Ile

200 205 210cgc gac gcc atg ttc cgc gcc cgc gac ctg cgc caa gac ccc atc gcc 787Arg Asp Ala Met Phe Arg Ala Arg Asp Leu Arg Gln Asp Pro Ile Ala

215 220 225atc gcc cgg aaa atc tct tcc cca gac ctt gca gcc atg gca gca ttc 835Ile Ala Arg Lys Ile Ser Ser Pro Asp Leu Ala Ala Met Ala Ala Phe230 235 240 245att gcc caa gca gca gtt cga cgc acc ccc gtg ctt ctc gac ggc gtt 883Ile Ala Gln Ala Ala Val Arg Arg Thr Pro Val Leu Leu Asp Gly Val

250 255 260gta gtc acc gcc gca gcc ctc cta gcc aac aaa ctg gcc cca ggt gcc 931Val Val Thr Ala Ala Ala Leu Leu Ala Asn Lys Leu Ala Pro Gly Ala

265 270 275agg cgt tgg ttc atc gca gga cac cgc tcc acc gaa cca gcg cat tcc 979Arg Arg Trp Phe Ile Ala Gly His Arg Ser Thr Glu Pro Ala His Ser

280 285 290gta gct cta aac gca ctg gcc ctt gat ccc atc ctg gaa ctt gga atg 1027Val Ala Leu Asn Ala Leu Ala Leu Asp Pro Ile Leu Glu Leu Gly Met

295 300 305tcc ctt ggc gaa ggc tcc ggc gca gcc acc gca ctc ccc ctg gtc aag 1075Ser Leu Gly Glu Gly Ser Gly Ala Ala Thr Ala Leu Pro Leu Val Lys310 315 320 325att gcc gtt gac ctg atg aac gac atg tcg aca ttt tct tcc gcc ggc1123Ile Ala Val Asp Leu Met Asn Asp Met Ser Thr Phe Ser Ser Ala Gly

330 335 340gtc gat gga ccc cta aac gcc tct tcc gaa gcg ccc gag caa aac acg 1171Val Asp Gly Pro Leu Asn Ala Ser Ser Glu Ala Pro Glu Gln Asn Thr

345350355 gag taactttcta agcgatgtcc ggc 1197Glu<210>836<211>358<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>836Met Val Pro Ala Glu Leu Phe Ala Arg Val Glu Phe Pro Asp His Lys 151015 Ile Leu Ala Gln Thr Lys Asp Phe His Asp Ser Leu Thr Lys Pro Pro

20 25 30Gly Ser Leu Gly Lys Leu Glu Gln Ile Gly Cys Phe Ile Ser Ala Cys

35 40 45Gln Gly Gln Ile Pro Pro Arg Pro Leu Asn Asn Ser Lys Ile Val Val

50 55 60Phe Ala Gly Asp His Gly Val Ala Thr Lys Gly Val Ser Ala Tyr Pro 65 70 75 80Ser Ser Val Ser Leu Gln Met Ala Glu Asn Ile Thr Asn Gly Gly Ala

85 90 95Ala Ile Asn Val Ile Ala Arg Thr Thr Gly Thr Ser Val Arg Leu Ile

100 105 110Asp Thr Ser Leu Asp His Glu Ala Trp Gly Asp Glu Arg Val Ser Arg

115 120 125Ser Cys Gly Ser Ile Asp Val Glu Asp Ala Met Thr Gln Glu Gln Val

130 135 140Glu Arg Ala Leu Lys Ile Gly Lys Arg Ile Ala Asp Gln Glu Val Asp145 150 155 160Ala Gly Ala Asp Ile Leu Ile Pro Gly Asp Leu Gly Ile Gly Asn Thr

165 170175Thr Thr Ala Ala Ala Leu Val Gly Thr Phe Thr Leu Ala Glu Pro Val

180 185 190Val Val Val Gly Arg Gly Thr Gly Ile Asp Asp Glu Ala Trp Lys Leu

195 200 205Lys Val Ser Ala Ile Arg Asp Ala Met Phe Arg Ala Arg Asp Leu Arg

210 215 220Gln Asp Pro Ile Ala Ile Ala Arg Lys Ile Ser Ser Pro Asp Leu Ala225 230 235 240Ala Met Ala Ala Phe Ile Ala Gln Ala Ala Val Arg Arg Thr Pro Val

245 250 255Leu Leu Asp Gly Val Val Val Thr Ala Ala Ala Leu Leu Ala Asn Lys

260 265 270Leu Ala Pro Gly Ala Arg Arg Trp Phe Ile Ala Gly His Arg Ser Thr

275 280 285Glu Pro Ala His Ser Val Ala Leu Asn Ala Leu Ala Leu Asp Pro Ile

290 295 300Leu Glu Leu Gly Met Ser Leu Gly Glu Gly Ser Gly Ala Ala Thr Ala305 310 315 320Leu Pro Leu Val Lys Ile Ala Val Asp Leu Met Asn Asp Met Ser Thr

325 330 335Phe Ser Ser Ala Gly Val Asp Gly Pro Leu Asn Ala Ser Ser Glu Ala

340 345 350Pro Glu Gln Asn Thr Glu

355<210>837<211>645<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (622)<223>RXA02136<400>837tggttttggt ctgggttact acgcgtattc ccgcaccatt cagcctcgta agtggcgtac 60ccctcgtgca cgcgttgaaa ttggtgctga agtctagcgc atg cgcacg tta gtt 115

Met Arg Thr Leu Val

1 5ctt ggc ggg gcc agg tct ggt aag tct gct ttt gca gaa tca ctt gtt 163Leu Gly Gly Ala Arg Ser Gly Lys Ser Ala Phe Ala Glu Ser Leu Val

10 15 20gga tct ggt ccc gtt ttg tat gtc gca acg gca agg cct tcg gga gat 211Gly Ser Gly Pro Val Leu Tyr Val Ala Thr Ala Arg Pro Ser Gly Asp

25 30 35gat cct gaa ttc gcc gag cgc att gcg gtt cat gcg gag cgg cgc cca 259Asp Pro Glu Phe Ala Glu Arg Ile Ala Val His Ala Glu Arg Arg Pro

40 45 50acg tct tgg gtg ttg gac gag gag ggg gac gtc gat aag ctt ctt gcc 307Thr Ser Trp Val Leu Asp Glu Glu Gly Asp Val Asp Lys Leu Leu Ala

55 60 65tcg cca ccg gcc atg ccg gtg ctc gtt gat gac ctg ggc acc tgg ctc 355Ser Pro Pro Ala Met Pro Val Leu Val Asp Asp Leu Gly Thr Trp Leu 70 75 80 85acg cac gcc acc gat gcg tgc gac ggt tgg gag gcg agt tcg gcg cag 403Thr His Ala Thr Asp Ala Cys Asp Gly Trp Glu Ala Ser Ser Ala Gln

90 95 100ctt gag gcc aag atg gat ttg ctt atc gac gcc atc ctc cac ttt cag 451Leu Glu Ala Lys Met Asp Leu Leu Ile Asp Ala Ile Leu His Phe Gln

105 110 115ggc gaa gat ctg gta att gtt tca cct gaa gtt ggt atg gga atc gtc 499Gly Glu Asp Leu Val Ile Val Ser Pro Glu Val Gly Met Gly Ile Val

120 125 130ccg gaa tat aaa tct ggg cgc ctt ttt cgt gat cgc atc ggc aca ctt 547Pro Glu Tyr Lys Ser Gly Arg Leu PheArg Asp Arg Ile Gly Thr Leu

135 140 145aat cag cgt gtc gca gcg att tgc gag agg gtt gtc ttc gtg gtt gct 595Asn Gln Arg Val Ala Ala Ile Cys Glu Arg Val Val Phe Val Val Ala150 155 160 165ggt ctg cca cta gag ttg aaa acg ttt taagaaaaca gtcggtttga 642Gly Leu Pro Leu Glu Leu Lys Thr Phe

170agg 645<210>838<211>174<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>838Met Arg Thr Leu Val Leu Gly Gly Ala Arg Ser Gly Lys Ser Ala Phe 151015 Ala Glu Ser Leu Val Gly Ser Gly Pro Val Leu Tyr Val Ala Thr Ala

20 25 30Arg Pro Ser Gly Asp Asp Pro Glu Phe Ala Glu Arg Ile Ala Val His

35 40 45Ala Glu Arg Arg Pro Thr Ser Trp Val Leu Asp Glu Glu Gly Asp Val

50 55 60Asp Lys Leu Leu Ala Ser Pro Pro Ala Met Pro Val Leu Val Asp Asp 65 70 75 80Leu Gly Thr Trp Leu Thr His Ala Thr Asp Ala Cys Asp Gly Trp Glu

85 90 95Ala Ser Ser Ala Gln Leu Glu Ala Lys Met Asp Leu Leu Ile Asp Ala

100 105 110Ile Leu His Phe Gln Gly Glu Asp Leu Val Ile Val Ser Pro Glu Val

115 120 125Gly Met Gly Ile Val Pro Glu Tyr Lys Ser Gly Arg Leu Phe Arg Asp

130 135 140Arg Ile Gly Thr Leu Asn Gln Arg Val Ala Ala Ile Cys Glu Arg Val145 150 155 160Val Phe Val Val Ala Gly Leu Pro Leu Glu Leu LysThr Phe

165170<210>839<211>575<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1).<552)<223>RXN03114<400>839act ccg ggg cat ttt gtt gcg ctc gcg cgg gag att gcg ggc gcg gtg 48Thr Pro Gly His Phe Val Ala Leu Ala Arg Glu Ile Ala Gly Ala Val 151015 cgc cgc gag ttg acg gtg ggg ttg gat gct ggt gac ggt ccg att tta 96Arg Arg Glu Leu Thr Val Gly Leu Asp Ala Gly Asp Gly Pro Ile Leu

20 25 30agg cag agc ttt gat gtt ggt ttt ttg ctt gtc gac gcc tcc ttc cac 144Arg Gln Ser Phe Asp Val Gly Phe Leu Leu Val Asp Ala Ser Phe His

35 40 45att cat atc aat ggc gtg tct act ggg cag tcg gtt gcg ccg gat gat 192Ile His Ile Asn Gly Val Ser Thr Gly Gln Ser Val Ala Pro Asp Asp

50 55 60gta gtt gag gtg gtg cgt ggt ttg gct gat gct tcg gag ttg tcc gtg 240Val Val Glu Val Val Arg Gly Leu Ala Asp Ala Ser Glu Leu Ser Val 65 70 75 80gaa agt gtt gct gag ttg tgt act ccc gtg gca ccg gtt tca tta tct 288Glu Ser Val Ala Glu Leu Cys Thr Pro Val Ala Pro Val Ser Leu Ser

85 90 95gag gca cag ggg aat cct gcg cct att ggg tgg ttg gag cat gat ggc 336Glu Ala Gln Gly Asn Pro Ala Pro Ile Gly Trp Leu Glu His Asp Gly

100 105 110gtg gtg tcg ttg ggt gcg ggt att cca ggg ggg cgg gtg gag gct cgt 384Val Val Ser Leu Gly Ala Gly Ile Pro Gly Gly Arg Val Glu Ala Arg

115 120 125tta gcg cgt ttt att gcg gtg att gag gcg gag acc act att acc cca 432Leu Ala Arg Phe Ile Ala Val Ile Glu Ala Glu ThrThr Ile Thr Pro

130 135 140tgg aat tcg ttg atc att cat gat ttg tat gag ggt gtt gca gaa cag 480Trp Asn Ser Leu Ile Ile His Asp Leu Tyr Glu Gly Val Ala Glu Gln145 150 155 160gtg gtg aag gtt ctg gct ccc atg ggg ttg gtt ttt gat gct aat tca 528Val Val Lys Val Leu Ala Pro Met Gly Leu Val Phe Asp Ala Asn Ser

165 170 175ccg ctt ctg gag tca ccg gct ttg taactcgcca ttggtgcacg tct 575Pro Leu Leu Glu Ser Pro Ala Leu

180<210>840<211>184<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>840Thr Pro Gly His Phe Val Ala Leu Ala Arg Glu Ile Ala Gly Ala Val 151015 Arg Arg Glu Leu Thr Val Gly Leu Asp Ala Gly Asp Gly Pro Ile Leu

20 25 30Arg Gln Ser Phe Asp Val Gly Phe Leu Leu Val Asp Ala Ser Phe His

35 40 45Ile His Ile Asn Gly Val Ser Thr Gly Gln Ser Val Ala Pro Asp Asp

50 55 60Val Val Glu Val Val Arg Gly Leu Ala Asp Ala Ser Glu Leu Ser Val 65 70 75 80Glu Ser Val Ala Glu Leu Cys Thr Pro Val Ala Pro Val Ser Leu Ser

85 90 95Glu Ala Gln Gly Asn Pro Ala Pro Ile Gly Trp Leu Glu His Asp Gly

100 105 110Val Val Ser Leu Gly Ala Gly Ile Pro Gly Gly Arg Val Glu Ala Arg

115 120 125Leu Ala Arg Phe Ile Ala Val Ile Glu Ala Glu Thr Thr Ile Thr Pro

130 135 140Trp Asn Ser Leu Ile Ile His Asp Leu Tyr Glu Gly Val Ala Glu Gln145 150 155 160Val Val Lys Val Leu Ala Pro Met Gly Leu Val Phe Asp Ala Asn Ser

165 170 175Pro Leu Leu Glu Ser Pro Ala Leu

180<210>841<211>1200<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1177)<223>RXN01810<400>841ccaccaccac aatgttgctc atcctcgcgg cgttcgttgt cgcaggtggc tccatgactc 60gcttcaccgt cggcaacccg actggaaaat aaggcttcac atg aat aac gct ttt 115

Met Asn Asn Ala Phe

1 5cga cgc acc ctt aca tcc gta gtc ctc gcc gct agc ttg gcc tta acg 163Arg Arg Thr Leu Thr Ser Val Val Leu Ala Ala Ser Leu Ala Leu Thr

10 15 20gcc tgc gca agc tgg gat tca cct acg gca tct tcc aat ggt gat ctg 211Ala Cys Ala Ser Trp Asp Ser Pro Thr Ala Ser Ser Asn Gly Asp Leu

25 30 35att gag gag atc cag gca agc tcc acc tca aca gat ccg cgc acc ttc 259Ile Glu Glu Ile Gln Ala Ser Ser Thr Ser Thr Asp Pro Arg Thr Phe

40 45 50aca ggc ttg agc atc gtg gaa gat atc ggc gat gtg gtt ccc gta acc 307Thr Gly Leu Ser Ile Val Glu Asp Ile Gly Asp Val Val Pro Val Thr

55 60 65gac aac gcc tca cca gct ctg cca gtt tct ttg acc gac gct gat ggc 355Asp Asn Ala Ser Pro Ala Leu Pro Val Ser Leu Thr Asp Ala Asp Gly 70 75 80 85aac gac gtg gtg gtg gag aac gtg tcc cgc atc ctc cca ctg gat ctc403Asn Asp Val Val Val Glu Asn Val Ser Arg Ile Leu Pro Leu Asp Leu

90 95 100tac gga acc tat tcc aaa acc atc gct ggc ctg gga ctc gtg gac aat 451Tyr Gly Thr Tyr Ser Lys Thr Ile Ala Gly Leu Gly Leu Val Asp Asn

105 110 115att gtg ggt cgt act gtt agt tcc acc gag cct gca ttg gcg gac att 499Ile Val Gly Arg Thr Val Ser Ser Thr Glu Pro Ala Leu Ala Asp Ile

120 125 130gag gtg gtc acc act ggc gga cac acc ctc aat gct gaa gcg atc ctt 547Glu Val Val Thr Thr Gly Gly His Thr Leu Asn Ala Glu Ala Ile Leu

135 140 145aat tta cat ccg act ttg gtg atc atc gac cac tcg atc ggc cca cgc 595Asn Leu His Pro Thr Leu Val Ile Ile Asp His Ser Ile Gly Pro Arg150 155 160 165gaa gtc atc gat cag atc cgc gca gct ggt gtc gcc acg gtg atc atg 643Glu Val Ile Asp Gln Ile Arg Ala Ala Gly Val Ala Thr Val Ile Met

170 175 180tcg ccg cag cgt tcc att gcc tca att ggc gac gac atc cgc gac atc 691Ser Pro Gln Arg Ser Ile Ala Ser Ile Gly Asp Asp Ile Arg Asp Ile

185 190 195gcc tcc gtc gtt gga ctt cct gaa gaa ggg gag aag ctc gcg gaa cgt 739Ala Ser Val Val Gly Leu Pro Glu Glu Gly Glu Lys Leu Ala Glu Arg

200 205 210tcc gtt gct gaa gtc gaa gag gcc agc acg gtt gtc gat gaa ctc acc 787Ser Val Ala Glu Val Glu Glu Ala Ser Thr Val Val Asp Glu Leu Thr

215 220 225cca gaa gat ccc ctc aaa atg gta ttc ctc tat gcc cgc gga act ggt 835Pro Glu Asp Pro Leu Lys Met Val Phe Leu Tyr Ala Arg Gly Thr Gly230235 240 245gga gtg ttc ttc att ttg ggc gat gcc tat ggt gga cgc gat ctc att 883Gly Val Phe Phe Ile Leu Gly Asp Ala Tyr Gly Gly Arg Asp Leu Ile

250 255 260gaa ggc ctg ggc ggc gtc gac atg gct gct gaa aag ggc atc atg gat 931Glu Gly Leu Gly Gly Val Asp Met Ala Ala Glu Lys Gly Ile Met Asp

265 270 275ctg gca cca gcc aac gcg gaa gca ctt gcc gaa cta aat cca gac gtc 979Leu Ala Pro Ala Asn Ala Glu Ala Leu Ala Glu Leu Asn Pro Asp Val

280 285 290ttc gtg atg atg tcg gaa gga cta gtc tcg aca gga ggt atc gac ggt 1027Phe Val Met Met Ser Glu Gly Leu Val Ser Thr Gly Gly Ile Asp Gly

295 300 305ctt atg gaa cgc ccc ggc att gct cag aca acc gcc gga caa aac caa 1075Leu Met Glu Arg Pro Gly Ile Ala Gln Thr Thr Ala Gly Gln Asn Gln310 315 320 325cga gta ctg gcg ctt ccc gat ggt caa tca ttg gcc ttt ggt gcc caa 1123Arg Val Leu Ala Leu Pro Asp Gly Gln Ser Leu Ala Phe Gly Ala Gln

330 335 340act ggc gag ttg ttg ctc cgc gca tcc cgc gaa ctg tat gtg cag ggc 1171Thr Gly Glu Leu Leu Leu Arg Ala Ser Arg Glu Leu Tyr Val Gln Gly

345350355 ggc gag tagatggttg tgaaggaggt tga 1200Gly Glu<210>842<211>359<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>842Met Asn Asn Ala Phe Arg Arg Thr Leu Thr Ser Val Val Leu Ala Ala 151015 Ser Leu Ala Leu Thr Ala Cys Ala Ser Trp Asp Ser Pro Thr Ala Ser

20 25 30Ser Asn Gly Asp Leu Ile Glu Glu Ile Gln Ala Ser Ser Thr Ser Thr

35 40 45Asp Pro Arg Thr Phe Thr Gly Leu Ser Ile Val Glu Asp Ile Gly Asp

50 55 60Val Val Pro Val Thr Asp Asn Ala Ser Pro Ala Leu Pro Val Ser Leu 65 70 75 80Thr Asp Ala Asp Gly Asn Asp Val Val Val Glu Asn Val Ser Arg Ile

85 90 95Leu Pro Leu Asp Leu Tyr Gly Thr Tyr Ser Lys Thr Ile Ala Gly Leu

100 105 110Gly Leu Val Asp Asn Ile Val Gly Arg Thr Val Ser Ser Thr Glu Pro

115 120 125Ala Leu Ala Asp Ile Glu Val Val Thr Thr Gly Gly His Thr Leu Asn

130 135 140Ala Glu Ala Ile Leu Asn Leu His Pro Thr Leu Val Ile Ile Asp His145 150 155 160Ser Ile Gly Pro Arg Glu Val Ile Asp Gln Ile Arg Ala Ala Gly Val

165 170 175Ala Thr Val Ile Met Ser Pro Gln Arg Ser Ile Ala Ser Ile Gly Asp

180 185 190Asp Ile Arg Asp Ile Ala Ser Val Val Gly Leu Pro Glu Glu Gly Glu

195 200 205Lys Leu Ala Glu Arg Ser Val Ala Glu Val Glu Glu Ala Ser Thr Val

210 215 220Val Asp Glu Leu Thr Pro Glu Asp Pro Leu Lys Met Val Phe Leu Tyr225 230 235 240Ala Arg Gly Thr Gly Gly Val Phe Phe Ile Leu Gly Asp Ala Tyr Gly

245 250 255Gly Arg Asp Leu Ile Glu Gly Leu Gly Gly Val Asp Met Ala Ala Glu

260 265 270Lys Gly Ile Met Asp Leu Ala Pro Ala Asn Ala Glu Ala Leu Ala Glu

275 280 285Leu Asn Pro Asp Val Phe Val Met Met Ser Glu Gly Leu Val Ser Thr

290 295 300Gly Gly Ile Asp Gly Leu Met Glu Arg Pro Gly Ile Ala Gln Thr Thr305 310 315 320Ala Gly Gln Asn Gln Arg Val Leu Ala Leu Pro Asp Gly Gln Ser Leu

325 330 335Ala Phe Gly Ala Gln Thr Gly Glu Leu Leu Leu Arg Ala Ser Arg Glu

340 345 350Leu Tyr Val Gln Gly Gly Glu

355<210>843<211>963<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (933)<223>RXS03205<400>843gat tcc ggc att ccc acg cag ttg gtg gag ggc agc tgg ttt gaa ccg 48Asp Ser Gly Ile Pro Thr Gln Leu Val Glu Gly Ser Trp Phe Glu Pro 151015 gtt cgc ggg cgc acc ttt gac cgc atc atc gcc aac ccg ccg ttc gtg 96Val Arg Gly Arg Thr Phe Asp Arg Ile Ile Ala Asn Pro Pro Phe Val

20 25 30gtg gga cca ccg gaa att ggg cat gtg tac cgc gat tcc ggc atg gat 144Val Gly Pro Pro Glu Ile Gly His Val Tyr Arg Asp Ser Gly Met Asp

35 40 45cta gac ggc gcg acc gcg ttg gtg gtc aaa gaa gcc tgc gcg cat ctc 192Leu Asp Gly Ala Thr Ala Leu Val Val Lys Glu Ala Cys Ala His Leu

50 55 60aac cct ggt ggc acc gct cac ctg ctc ggc gca tgg gtg cat tcc gcg 240Asn Pro Gly Gly Thr Ala His Leu Leu Gly Ala Trp Val His Ser Ala 65 70 7580gat caa tcg tgg cag cag cgc gtt gca gaa tgg ttg ccg gat aac ggt 288Asp Gln Ser Trp Gln Gln Arg Val Ala Glu Trp Leu Pro Asp Asn Gly

85 90 95tat gtt gct tgg gtt att gag cgc gac gcc gtg agc ccc gcg cag tat 336Tyr Val Ala Trp Val Ile Glu Arg Asp Ala Val Ser Pro Ala Gln Tyr

100 105 110gtg ggc acg tgg ctt agt gat gag tcc ctc gat ctg cgt agc ccc gag 384Val Gly Thr Trp Leu Ser Asp Glu Ser Leu Asp Leu Arg Ser Pro Glu

115 120 125gca gca gca cgc acc acc gcg tgg ctt aac cac ttt gaa aaa gcc aag 432Ala Ala Ala Arg Thr Thr Ala Trp Leu Asn His Phe Glu Lys Ala Lys

130 135 140gtt caa ggc gtt ggt ttt ggt ttc atc gcc atc caa cgt ctg gag gaa 480Val Gln Gly Val Gly Phe Gly Phe Ile Ala Ile Gln Arg Leu Glu Glu145 150 155 160gac gag gcg gat gag aaa tcc gat atc ttg gct gaa tcc atg acc cag 528Asp Glu Ala Asp Glu Lys Ser Asp Ile Leu Ala Glu Ser Met Thr Gln

165 170 175tac ttc gag gat cct ctc ggc cct gaa att gag gag tac ttc acc cgc 576Tyr Phe Glu Asp Pro Leu Gly Pro Glu Ile Glu Glu Tyr Phe Thr Arg

180 185 190acc gca tgg ctt cgt gaa caa act cgc gat tcc att ctg agc tcc cgc 624Thr Ala Trp Leu Arg Glu Gln Thr Arg Asp Ser Ile Leu Ser Ser Arg

195 200 205ttc aaa gtt cgc cct ggc gtg gcc cgg gaa caa atc agc ctg gcc gat 672Phe Lys Val Arg Pro Gly Val Ala Arg Glu Gln Ile Ser Leu Ala Asp

210 215 220gcg gaa gaa ggc atg ggc ttt agt cct gtc acg ttg agg ctc acccgc 720Ala Glu Glu Gly Met Gly Phe Ser Pro Val Thr Leu Arg Leu Thr Arg225 230 235 240acc gat ggt cct cgt tgg tcc cat gat gtt gat gag cat gtg gct tcc 768Thr Asp Gly Pro Arg Trp Ser His Asp Val Asp Glu His Val Ala Ser

245 250 255atc gtc gca gga ctt aac cca cat gga ctc ccc ttt gaa gaa atc ctg 816Ile Val Ala Gly Leu Asn Pro His Gly Leu Pro Phe Glu Glu Ile Leu

260 265 270gaa atg tac gcg atg gct caa ggt atc gag gga gaa tcc ctg cac aac 864Glu Met Tyr Ala Met Ala Gln Gly Ile Glu Gly Glu Ser Leu His Asn

275 280 285ggc gcc att gcg gcg ttg gtg gat ctc atc cgc cac gga ttg gtg ttg 912Gly Ala Ile Ala Ala Leu Val Asp Leu Ile Arg His Gly Leu Val Leu

290295300 ccc gct gat ctt ctc gat tct taaataagga ctgattgtga aagccgtttt 963Pro Ala Asp Leu Leu Asp Ser 305310<210>844<211>311<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>844Asp Ser Gly Ile Pro Thr Gln Leu Val Glu Gly Ser Trp Phe Glu Pro 151015 Val Arg Gly Arg Thr Phe Asp Arg Ile Ile Ala Asn Pro Pro Phe Val

20 25 30Val Gly Pro Pro Glu Ile Gly His Val Tyr Arg Asp Ser Gly Met Asp

35 40 45Leu Asp Gly Ala Thr Ala Leu Val Val Lys Glu Ala Cys Ala His Leu

50 55 60Asn Pro Gly Gly Thr Ala His Leu Leu Gly Ala Trp Val His Ser Ala 65 70 75 80Asp Gln Ser Trp Gln Gln Arg Val Ala Glu Trp Leu Pro Asp Asn Gly

85 90 95Tyr Val Ala Trp Val Ile Glu Arg Asp Ala Val Ser Pro Ala Gln Tyr

100 105 110Val Gly Thr Trp Leu Ser Asp Glu Ser Leu Asp Leu Arg Ser Pro Glu

115 120 125Ala Ala Ala Arg Thr Thr Ala Trp Leu Asn His Phe Glu Lys Ala Lys

130 135 140Val Gln Gly Val Gly Phe Gly Phe Ile Ala Ile Gln Arg Leu Glu Glu145 150 155 160Asp Glu Ala Asp Glu Lys Ser Asp Ile Leu Ala Glu Ser Met Thr Gln

165 170 175Tyr Phe Glu Asp Pro Leu Gly Pro Glu Ile Glu Glu Tyr Phe Thr Arg

180 185 190Thr Ala Trp Leu Arg Glu Gln Thr Arg Asp Ser Ile Leu Ser Ser Arg

195 200 205Phe Lys Val Arg Pro Gly Val Ala Arg Glu Gln Ile Ser Leu Ala Asp

210 215 220Ala Glu Glu Gly Met Gly Phe Ser Pro Val Thr Leu Arg Leu Thr Arg225 230 235 240Thr Asp Gly Pro Arg Trp Ser His Asp Val Asp Glu His Val Ala Ser

245 250 255Ile Val Ala Gly Leu Asn Pro His Gly Leu Pro Phe Glu Glu Ile Leu

260 265 270Glu Met Tyr Ala Met Ala Gln Gly Ile Glu Gly Glu Ser Leu His Asn

275 280 285Gly Ala Ile Ala Ala Leu Val Asp Leu Ile Arg His Gly Leu Val Leu

290295300 Pro Ala Asp Leu Leu Asp Ser 305310<210>845<211>956<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1).<933)<223>FRXA00306<400>845gat tcc ggc att ccc acg cag ttg gtg gag ggc agc tgg ttt gaa ccg 48Asp Ser Gly Ile Pro Thr Gln Leu Val Glu Gly Ser Trp Phe Glu Pro 151015 gtt cgc ggg cgc acc ttt gac cgc atc atc gcc aac ccg ccg ttc gtg 96Val Arg Gly Arg Thr Phe Asp Arg Ile Ile Ala Asn Pro Pro Phe Val<400>845gat tcc ggc att ccc acg cag ttg gtg gag ggc agc tgg ttt gaa ccg Asp Ser Gly Ile Pro Thr Gln Leu Val Glu Gly Ser Trp Phe Glu Pro gtt cgc ggg cgc acc ttt gac cgc atc atc gcc aac ccg ccg ttc gtg Val Arg Gly Arg Thr Phe Asp Arg Ile Ile Ala Asn Pro Pro Phe Val

20 25 30gtg gga cca ccg gaa att ggg cat gtg tac cgc gat tcc ggc atg gat 144Val Gly Pro Pro Glu Ile Gly His Val Tyr Arg Asp Ser Gly Met Asp

35 40 45cta gac ggc gcg acc gcg ttg gtg gtc aaa gaa gcc tgc gcg cat ctc 192Leu Asp Gly Ala Thr Ala Leu Val Val Lys Glu Ala Cys Ala His Leu

50 55 60aac cct ggt ggc acc gct cac ctg ctc ggc gca tgg gtg cat tcc gcg 240Asn Pro Gly Gly Thr Ala His Leu Leu Gly Ala Trp Val His Ser Ala65 70 75 80gat caa tcg tgg cag cag cgc gtt gca gaa tgg ttg ccg gat aac ggt 288Asp Gln Ser Trp Gln Gln Arg Val Ala Glu Trp Leu Pro Asp Asn Gly

85 90 95tat gtt gct tgg gtt att gag cgc gac gcc gtg agc ccc gcg cag tat 336Tyr Val Ala Trp Val Ile Glu Arg Asp Ala Val Ser Pro Ala Gln Tyr

100 105 110gtg ggc acg tgg ctt agt gat gag tcc ctc gat ctg cgt agc ccc gag 384Val Gly Thr Trp Leu Ser Asp Glu Ser Leu Asp Leu Arg Ser Pro Glu

115 120 125gca gca gca cgc acc acc gcg tgg ctt aac cacttt gaa aaa gcc aag 432Ala Ala Ala Arg Thr Thr Ala Trp Leu Asn His Phe Glu Lys Ala Lys

130 135 140gtt caa ggc gtt ggt ttt ggt ttc atc gcc atc caa cgt ctg gag gaa 480Val Gln Gly Val Gly Phe Gly Phe Ile Ala Ile Gln Arg Leu Glu Glu145 150 155 160gac gag gcg gat gag aaa tcc gat atc ttg gct gaa tcc atg acc cag 528Asp Glu Ala Asp Glu Lys Ser Asp Ile Leu Ala Glu Ser Met Thr Gln

165 170 175tac ttc gag gat cct ctc ggc cct gaa att gag gag tac ttc acc cgc 576Tyr Phe Glu Asp Pro Leu Gly Pro Glu Ile Glu Glu Tyr Phe Thr Arg

180 185 190acc gca tgg ctt cgt gaa caa act cgc gat tcc att ctg agc tcc cgc 624Thr Ala Trp Leu Arg Glu Gln Thr Arg Asp Ser Ile Leu Ser Ser Arg

195 200 205ttc aaa gtt cgc cct ggc gtg gcc cgg gaa caa atc agc ctg gcc gat 672Phe Lys Val Arg Pro Gly Val Ala Arg Glu Gln Ile Ser Leu Ala Asp

210 215 220gcg gaa gaa ggc atg ggc ttt agt cct gtc acg ttg agg ctc acc cgc 720Ala Glu Glu Gly Met Gly Phe Ser Pro Val Thr Leu Arg Leu Thr Arg225 230 235 240acc gat ggt cct cgt tgg tcc cat gat gtt gat gag cat gtg gct tcc 768Thr Asp Gly Pro Arg Trp Ser His Asp Val Asp Glu His Val Ala Ser

245 250 255atc gtc gca gga ctt aac cca cat gga ctc ccc ttt gaa gaa atc ctg 816Ile Val Ala Gly Leu Asn Pro His Gly Leu Pro Phe Glu Glu Ile Leu

260 265 270gaa atg tac gcg atg gct caa ggt atc gag gga gaa tcc ctg cac aac 864Glu Met Tyr Ala Met Ala Gln Gly Ile Glu Gly Glu Ser Leu His Asn

275 280 285ggc gcc att gcg gcg ttg gtg gat ctc atc cgc cac gga ttg gtg ttg 912Gly Ala Ile Ala Ala Leu Val Asp Leu Ile Arg His Gly Leu Val Leu

290295300 ccc gct gat ctt ctc gat tct taaataagga ctgattgtga aag 956Pro Ala Asp Leu Leu Asp Ser 305310<210>846<211>311<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>846Asp Ser Gly Ile Pro Thr Gln Leu Val Glu Gly Ser Trp Phe Glu Pro 151015 Val Arg Gly Arg Thr Phe Asp Arg Ile Ile Ala Asn Pro Pro Phe Val

20 25 30Val Gly Pro Pro Glu Ile Gly His Val Tyr Arg Asp Ser Gly Met Asp

35 40 45Leu Asp Gly Ala Thr Ala Leu Val Val Lys Glu Ala Cys Ala His Leu

50 55 60Asn Pro Gly Gly Thr Ala His Leu Leu Gly Ala Trp Val His Ser Ala 65 70 75 80Asp Gln Ser Trp Gln Gln Arg Val Ala Glu Trp Leu Pro Asp Asn Gly

85 90 95Tyr Val Ala Trp Val Ile Glu Arg Asp Ala Val Ser Pro Ala Gln Tyr

100 105 110Val Gly Thr Trp Leu Ser Asp Glu Ser Leu Asp Leu Arg Ser Pro Glu

115 120 125Ala Ala Ala Arg Thr Thr Ala Trp Leu Asn His Phe Glu Lys Ala Lys

130 135 140Val Gln Gly Val Gly Phe Gly Phe Ile Ala Ile Gln Arg Leu Glu Glu145 150 155 160Asp Glu Ala Asp Glu Lys Ser Asp Ile Leu Ala Glu Ser Met Thr Gln

165 170 175Tyr Phe Glu Asp Pro Leu Gly Pro Glu Ile Glu Glu Tyr Phe Thr Arg

180 185 190Thr Ala Trp Leu Arg Glu Gln Thr Arg Asp Ser Ile Leu Ser Ser Arg

195 200 205Phe Lys Val Arg Pro Gly Val Ala Arg Glu Gln Ile Ser Leu Ala Asp

210 215 220Ala Glu Glu Gly Met Gly Phe Ser Pro Val Thr Leu Arg Leu Thr Arg225 230 235 240Thr Asp Gly Pro Arg Trp Ser His Asp Val Asp Glu His Val Ala Ser

245 250 255Ile Val Ala Gly Leu Asn Pro His Gly Leu Pro Phe Glu Glu Ile Leu

260 265 270Glu Met Tyr Ala Met Ala Gln Gly Ile Glu Gly Glu Ser Leu His Asn

275 280 285Gly Ala Ile Ala Ala Leu Val Asp Leu Ile Arg His Gly Leu Val Leu

290295300 Pro Ala Asp Leu Leu Asp Ser 305310<210>847<211>819<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) · (796)<223>RXC01715<400>847acatgttgtt ggaacatgcc ggcagagccg acactacgat tcattcgcta aagggtctgg 60ccactgacac tggcaaagat ccacgaaagg aagttaccct gtg agc gag ctc gat 115

Val Ser Glu Leu Asp

1 5att aaa cag ctc aac aaa ctg cag cgc tac tct cag tgg gcg gtg ttc 163Ile Lys Gln Leu Asn Lys Leu Gln Arg Tyr Ser Gln Trp Ala Val Phe

10 15 20cgt gct att cct gga gcg ctc gat gat gat cgc aca gaa gtc act gac 211Arg Ala Ile Pro Gly Ala Leu Asp AspAsp Arg Thr Glu Val Thr Asp

25 30 35caa gca gcc aag ttc ttt gcc gac ctt gaa gca gaa ggc aaa gtc act 259Gln Ala Ala Lys Phe Phe Ala Asp Leu Glu Ala Glu Gly Lys Val Thr

40 45 50gtc cgt ggc att tac aac gcc tcc ggc ctg cgc gca gac gct gac tac 307Val Arg Gly Ile Tyr Asn Ala Ser Gly Leu Arg Ala Asp Ala Asp Tyr

55 60 65atg atc tgg tgg cac gca gaa gaa ttc gaa gac att cag aag gcc ttc 355Met Ile Trp Trp His Ala Glu Glu Phe Glu Asp Ile Gln Lys Ala Phe 70 75 80 85gct gat ttc cgc cgc acc acc att ttg ggt cag gtt tct gag gtc ttc 403Ala Asp Phe Arg Arg Thr Thr Ile Leu Gly Gln Val Ser Glu Val Phe

90 95 100tgg atc gga aac gct ctc cac cgt cca tct gag ttc aac aag gct cac 451Trp Ile Gly Asn Ala Leu His Arg Pro Ser Glu Phe Asn Lys Ala His

105 110 115ttg cct tca ttc atc atg ggt gaa gaa gca aag gac tgg atc act gtt 499Leu Pro Ser Phe Ile Met Gly Glu Glu Ala Lys Asp Trp Ile Thr Val

120 125 130tac ccg ttc gtg cgc agc tac gac tgg tac atc atg gag ccc ttg aag 547Tyr Pro Phe Val Arg Ser Tyr Asp Trp Tyr Ile Met Glu Pro Leu Lys

135 140 145cgt tcc cgc att ctc cgc gag cac gga caa gct gct gtg gaa ttc cca 595Arg Ser Arg Ile Leu Arg Glu His Gly Gln Ala Ala Val Glu Phe Pro150 155 160 165gat gtt cgt gcc aac act gtg ccg gct ttc gca ctg ggt gac tac gaa 643Asp Val Arg Ala Asn Thr Val Pro Ala Phe Ala Leu Gly Asp Tyr Glu

170 175180tgg gtg ctg gct ttc gag gct gat gag ttg cac cgc att gtc gat ttg 691Trp Val Leu Ala Phe Glu Ala Asp Glu Leu His Arg Ile Val Asp Leu

185 190 195atg cac aag atg cgt tac acc gag gct cgc ctc cac gtc cgt gag gag 739Met His Lys Met Arg Tyr Thr Glu Ala Arg Leu His Val Arg Glu Glu

200 205 210ctg cca ttt att tct gga cag cgc gtc gac att gca gat ctg att aag 787Leu Pro Phe Ile Ser Gly Gln Arg Val Asp Ile Ala Asp Leu Ile Lys

215220225 gtt ctt cct taaaagctgc ttttctaaac gat 819Val Leu Pro230<210>848<211>232<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>848Val Ser Glu Leu Asp Ile Lys Gln Leu Asn Lys Leu Gln Arg Tyr Ser 151015 Gln Trp Ala Val Phe Arg Ala Ile Pro Gly Ala Leu Asp Asp Asp Arg

20 25 30Thr Glu Val Thr Asp Gln Ala Ala Lys Phe Phe Ala Asp Leu Glu Ala

35 40 45Glu Gly Lys Val Thr Val Arg Gly Ile Tyr Asn Ala Ser Gly Leu Arg

50 55 60Ala Asp Ala Asp Tyr Met Ile Trp Trp His Ala Glu Glu Phe Glu Asp 65 70 75 80Ile Gln Lys Ala Phe Ala Asp Phe Arg Arg Thr Thr Ile Leu Gly Gln

85 90 95Val Ser Glu Val Phe Trp Ile Gly Asn Ala Leu His Arg Pro Ser Glu

100 105 110Phe Asn Lys Ala His Leu Pro Ser Phe Ile Met Gly Glu Glu Ala Lys

115 120 125Asp Trp Ile Thr Val Tyr Pro Phe Val Arg Ser Tyr Asp Trp Tyr Ile

130135 140Met Glu Pro Leu Lys Arg Ser Arg Ile Leu Arg Glu His Gly Gln Ala145 150 155 160Ala Val Glu Phe Pro Asp Val Arg Ala Asn Thr Val Pro Ala Phe Ala

165 170 175Leu Gly Asp Tyr Glu Trp Val Leu Ala Phe Glu Ala Asp Glu Leu His

180 185 190Arg Ile Val Asp Leu Met His Lys Met Arg Tyr Thr Glu Ala Arg Leu

195 200 205His Val Arg Glu Glu Leu Pro Phe Ile Ser Gly Gln Arg Val Asp Ile

210215220 Ala Asp Leu Ile Lys Val Leu Pro 225230<210>849<211>1587<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1564)<223>RXN00420<400>849attcgtgaac tcatggatct ttaggcaata aatgtgagat tggacgattt cacgcttgtc 60ttcaccacct gaaaattttc gggggtaacc tttaaaggcg atg aac agt tct cac 115

Met Asn Ser Ser His

1 5ggc acg tcc agc tcc ggc gct tcg gcc ggt gcc cac gga gcc ctt ccc 163Gly Thr Ser Ser Ser Gly Ala Ser Ala Gly Ala His Gly Ala Leu Pro

10 15 20cta gaa gct cag aaa ctg aac ggt tgg ggc cgc aca gcc ccc acc acc 211Leu Glu Ala Gln Lys Leu Asn Gly Trp Gly Arg Thr Ala Pro Thr Thr

25 30 35gct gag gta ctt acc acc cca gac cta gac atc att gtg gat gca gtc 259Ala Glu Val Leu Thr Thr Pro Asp Leu Asp Ile Ile Val Asp Ala Val

40 45 50cgc caa gtc gct gaa caa aac gac tcc aag ccg gac tac ctc aag cgc 307Arg Gln Val Ala Glu Gln Asn Asp Ser Lys Pro Asp Tyr Leu Lys Arg

55 60 65ggc gtg att gcc cgt ggc atg ggt cgt tcc tat ggt gac cca gcc caa 355Gly Val Ile Ala Arg Gly Met Gly Arg Ser Tyr Gly Asp Pro Ala Gln 70 75 80 85aac gcc ggt ggc ctt gtc att gac atg cag cca ctg aac aaa atc cac 403Asn Ala Gly Gly Leu Val Ile Asp Met Gln Pro Leu Asn Lys Ile His

90 95 100tcg att gat cct gat tct gcg atc gtc gat gta gat ggc ggc gtc acc 451Ser Ile Asp Pro Asp Ser Ala Ile Val Asp Val Asp Gly Gly Val Thr

105 110 115ctc gat cag ctc atg aag gct gcc ctg cca tat ggc ctc tgg gtt cct 499Leu Asp Gln Leu Met Lys Ala Ala Leu Pro Tyr Gly Leu Trp Val Pro

120 125 130gtc ctt ccc ggc acc cgc caa gtc acc atc ggt ggc gca atc gga cca 547Val Leu Pro Gly Thr Arg Gln Val Thr Ile Gly Gly Ala Ile Gly Pro

135 140 145gac atc cac ggt aag aac cac cac tct gca ggt tcc ttc ggc gac cac 595Asp Ile His Gly Lys Asn His His Ser Ala Gly Ser Phe Gly Asp His150 155 160 165gtg gtc tcc atg gaa ctc ctc gtt gca gac gga cgc atc ctg cac ctc 643Val Val Ser Met Glu Leu Leu Val Ala Asp Gly Arg Ile Leu His Leu

170 175 180gag cca gaa ggc acc gcc gaa gac cca cag ggc gac ctg ttc tgg gca 691Glu Pro Glu Gly Thr Ala Glu Asp Pro Gln Gly Asp Leu Phe Trp Ala

185 190 195acc gtt ggt ggc atg ggc ctg acc ggc atc atc gtc cgt gca cgc atc 739Thr Val Gly Gly Met Gly Leu Thr Gly Ile Ile Val Arg Ala Arg Ile

200 205 210cgc atg acc aag acg gaa acc gcc tac ttc att gcg gac acc gac cgc 787Arg Met Thr Lys Thr Glu Thr Ala Tyr Phe Ile Ala Asp Thr Asp Arg

215 220 225acc aac aac ttg gaa gaa acc gtt gcg ttc cac tcc gac gga tca gag 835Thr Asn Asn Leu Glu Glu Thr Val Ala Phe His Ser Asp Gly Ser Glu230 235 240 245cac aac tac acc tat tct tct gcg tgg ttc gat gtc atc agc cct gag 883His Asn Tyr Thr Tyr Ser Ser Ala Trp Phe Asp Val Ile Ser Pro Glu

250 255 260cca aag ctt ggc cgc tcc acc atc tcc cgt ggt tcc ctg gca aca ctt 931Pro Lys Leu Gly Arg Ser Thr Ile Ser Arg Gly Ser Leu Ala Thr Leu

265 270 275gct cag ctg gaa gaa ttg gca cca aag ctg gcc aag gat cca ctg aag 979Ala Gln Leu Glu Glu Leu Ala Pro Lys Leu Ala Lys Asp Pro Leu Lys

280 285 290ttt aat gct cca cag ctg atg aag gtt cca gat atc ttc cca tcc tgg 1027Phe Asn Ala Pro Gln Leu Met Lys Val Pro Asp Ile Phe Pro Ser Trp

295 300 305act ttg aac aag ctg acc ctt tcc gca gtc ggt gtg gct tac tac gcc 1075Thr Leu Asn Lys Leu Thr Leu Ser Ala Val Gly Val Ala Tyr Tyr Ala310 315 320 325atg ggt gca cca gcg aaa aac cag gtg aaa aac ctc acc cag ttc tac 1123Met Gly Ala Pro Ala Lys Asn Gln Val Lys Asn Leu Thr Gln Phe Tyr

330 335 340caa cca ctg gat ttg atc ggc gaa tgg aac cgt ggc tac ggc tcc aag 1171Gln Pro Leu Asp Leu Ile Gly Glu Trp Asn Arg Gly Tyr Gly Ser Lys

345 350 355ggc ttc ctg cag tac cag ttc gtg gtc ccc aca gaa gct gtt gag cct 1219Gly Phe Leu Gln Tyr Gln Phe Val Val Pro Thr Glu Ala Val Glu Pro

360 365 370ttc aag gac atc atc cgc gat atg caa aag tcc ggc cac tac tcc gca 1267Phe Lys Asp Ile Ile Arg Asp Met Gln Lys Ser Gly His Tyr Ser Ala

375 380 385ctc aac gtg ttc aaa ctg ttt ggc cca ggc aac cgc gca cca ctg tcc 1315Leu Asn Val Phe Lys Leu Phe Gly Pro Gly Asn Arg Ala Pro Leu Ser390 395 400 405tac cca atg cca ggc tgg aac gtc tgc gtt gac ttc cct atc cgc cca 1363Tyr Pro Met Pro Gly Trp Asn Val Cys Val Asp Phe Pro Ile Arg Pro

410 415 420ggt ctg gga gct ttc ttg gac gat ctg gac aag cgc gtc atg gaa ttc 1411Gly Leu Gly Ala Phe Leu Asp Asp Leu Asp Lys Arg Val Met Glu Phe

425 430 435ggc ggc cgc ctc tac ctg gcc aag gaa tcc cgc acc tcc gca gag aac 1459Gly Gly Arg Leu Tyr Leu Ala Lys Glu Ser Arg Thr Ser Ala Glu Asn

440 445 450ttc cac gcc atg tac cca ggt atg gaa ggc tgg ttg aag act cga aat 1507Phe His Ala Met Tyr Pro Gly Met Glu Gly Trp Leu Lys Thr Arg Asn

455460465 gag atc gac cca acc gga gtc ttt gca tct gac atg tcc cgc cga ctt 1555Glu Ile Asp Pro Thr Gly Val Phe Ala Ser Asp Met Ser Arg Arg Leu 470475480485 gag ctt tct taagaaaggg cttgaactaa aca 1587Glu Leu Ser<210>850<211>488<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>850Met Asn Ser Ser His Gly Thr Ser Ser Ser Gly Ala Ser Ala Gly Ala 151015 His Gly Ala Leu Pro Leu Glu Ala Gln Lys Leu Asn Gly Trp Gly Arg

20 25 30Thr Ala Pro Thr Thr Ala Glu Val Leu Thr Thr Pro Asp Leu Asp Ile

35 40 45Ile Val Asp Ala Val Arg Gln Val Ala Glu Gln Asn Asp Ser Lys Pro

50 55 60Asp Tyr Leu Lys Arg Gly Val Ile Ala Arg Gly Met Gly Arg Ser Tyr 65 70 75 80Gly Asp Pro Ala Gln Asn Ala Gly Gly Leu Val Ile Asp Met Gln Pro

85 90 95Leu Asn Lys Ile His Ser Ile Asp Pro Asp Ser Ala Ile Val Asp Val

100 105 110Asp Gly Gly Val Thr Leu Asp Gln Leu Met Lys Ala Ala Leu Pro Tyr

115 120 125Gly Leu Trp Val Pro Val Leu Pro Gly Thr Arg Gln Val Thr Ile Gly

130 135 140Gly Ala Ile Gly Pro Asp Ile His Gly Lys Asn His His Ser Ala Gly145 150 155 160Ser Phe Gly Asp His Val Val Ser Met Glu Leu Leu Val Ala Asp Gly

165 170 175Arg Ile Leu His Leu Glu Pro Glu Gly Thr Ala Glu Asp Pro Gln Gly

180 185 190Asp Leu Phe Trp Ala Thr Val Gly Gly Met Gly Leu Thr Gly Ile Ile

195 200 205Val Arg Ala Arg Ile Arg Met Thr Lys Thr Glu Thr Ala Tyr Phe Ile

210 215 220Ala Asp Thr Asp Arg Thr Asn Asn Leu Glu Glu Thr Val Ala Phe His225 230 235 240Ser Asp Gly Ser Glu His Asn Tyr Thr Tyr Ser Ser Ala Trp Phe Asp

245 250 255Val Ile Ser Pro Glu Pro Lys Leu Gly Arg Ser Thr Ile Ser Arg Gly

260 265 270Ser Leu Ala Thr Leu Ala Gln Leu Glu Glu Leu Ala Pro Lys Leu Ala

275 280 285Lys Asp Pro Leu Lys Phe Asn Ala Pro Gln Leu Met Lys Val Pro Asp

290 295 300Ile Phe Pro Ser Trp Thr Leu Asn Lys Leu Thr Leu Ser Ala Val Gly305 310 315 320Val Ala Tyr Tyr Ala Met Gly Ala Pro Ala Lys Asn Gln Val Lys Asn

325 330 335Leu Thr Gln Phe Tyr Gln Pro Leu Asp Leu Ile Gly Glu Trp Asn Arg

340 345 350Gly Tyr Gly Ser Lys Gly Phe Leu Gln Tyr Gln Phe Val Val Pro Thr

355 360 365Glu Ala Val Glu Pro Phe Lys Asp Ile Ile Arg Asp Met Gln Lys Ser

370 375 380Gly His Tyr Ser Ala Leu Asn Val Phe Lys Leu Phe Gly Pro Gly Asn385 390 395 400Arg Ala Pro Leu Ser Tyr Pro Met Pro Gly Trp Asn Val Cys Val Asp

405 410 415Phe Pro Ile Arg Pro Gly Leu Gly Ala Phe Leu Asp Asp Leu Asp Lys

420 425 430Arg Val Met Glu Phe Gly Gly Arg Leu Tyr Leu Ala Lys Glu Ser Arg

435 440 445Thr Ser Ala Glu Asn Phe His Ala Met Tyr Pro Gly Met Glu Gly Trp

450 455 460Leu Lys Thr Arg Asn Glu Ile Asp Pro Thr Gly Val Phe Ala Ser Asp465 470 475 480Met Ser Arg Arg Leu Glu Leu Ser

485<210>851<211>563<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (540)<223>FRXA00420<400>851tgg act ttg aac aag ctg acc ctt tcc gca gtc ggt gtg gct tac tac 48Trp Thr Leu Asn Lys Leu Thr Leu Ser Ala Val Gly Val Ala Tyr Tyr 151015 gcc atg ggt gca cca gcg aaa aac cag gtg aaa aac ctc acc cag ttc 96Ala Met Gly Ala Pro Ala Lys Asn Gln Val Lys Asn Leu Thr Gln Phe

20 25 30tac caa cca ctg gat ttg atc ggc gaa tgg aac cgt ggc tac ggc tcc 144Tyr Gln Pro Leu Asp Leu Ile Gly Glu Trp Asn Arg Gly Tyr Gly Ser

35 40 45aag ggc ttc ctg cag tac cag ttc gtg gtc ccc aca gaa gct gtt gag 192Lys Gly Phe Leu Gln Tyr Gln Phe Val Val Pro Thr Glu Ala Val Glu

50 55 60cct ttc aag gac atc atc cgc gat atg caa aag tcc ggc cac tac tcc 240Pro Phe Lys Asp Ile Ile Arg Asp Met Gln Lys Ser Gly His Tyr Ser 65 70 75 80gca ctc aac gtg ttc aaa ctg ttt ggc cca ggc aac cgc gca cca ctg 288Ala Leu Asn Val Phe Lys Leu Phe Gly Pro Gly Asn Arg Ala Pro Leu

85 90 95tcc tac cca atg cca ggc tgg aac gtc tgc gtt gac ttc cct atc cgc 336Ser Tyr Pro Met Pro Gly Trp Asn Val Cys Val Asp Phe Pro Ile Arg

100 105 110cca ggt ctg gga gct ttc ttg gac gat ctg gac aag cgc gtc atg gaa 384Pro Gly Leu Gly Ala Phe Leu Asp Asp Leu Asp Lys Arg Val Met Glu

115 120 125ttc ggc ggc cgc ctc tac ctg gcc aag gaa tcc cgc acc tcc gca gag 432Phe Gly Gly Arg Leu Tyr Leu Ala Lys Glu Ser Arg Thr Ser Ala Glu

130 135 140aac ttc cac gcc atg tac cca ggt atg gaa ggc tgg ttg aag act cga 480Asn Phe His Ala Met Tyr Pro Gly Met Glu Gly Trp Leu Lys Thr Arg145 150 155 160aat gag atc gac cca acc gga gtc ttt gca tct gac atg tcc cgc cga 528Asn Glu Ile Asp Pro Thr Gly Val Phe Ala Ser Asp Met Ser Arg Arg

165 170 175ctt gag ctt tct taagaaaggg cttgaactaa aca 563Leu Glu Leu Ser

180<210>852<211>180<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>852Trp Thr Leu Asn Lys Leu Thr Leu Ser Ala Val Gly Val Ala Tyr Tyr 151015 Ala Met Gly Ala Pro Ala Lys Asn Gln Val Lys Asn Leu Thr Gln Phe

20 25 30Tyr Gln Pro Leu Asp Leu Ile Gly Glu Trp Asn Arg Gly Tyr Gly Ser

35 40 45Lys Gly Phe Leu Gln Tyr Gln Phe Val Val Pro Thr Glu Ala Val Glu

50 55 60Pro Phe Lys Asp Ile Ile Arg Asp Met Gln Lys Ser Gly His Tyr Ser 65 70 75 80Ala Leu Asn Val Phe Lys Leu Phe Gly Pro Gly Asn Arg Ala Pro Leu

85 90 95Ser Tyr Pro Met Pro Gly Trp Asn Val Cys Val Asp Phe Pro Ile Arg

100 105 110Pro Gly Leu Gly Ala Phe Leu Asp Asp Leu Asp Lys Arg Val Met Glu

115 120 125Phe Gly Gly Arg Leu Tyr Leu Ala Lys Glu Ser Arg Thr Ser Ala Glu

130 135 140Asn Phe His Ala MetTyr Pro Gly Met Glu Gly Trp Leu Lys Thr Arg145 150 155 160Asn Glu Ile Asp Pro Thr Gly Val Phe Ala Ser Asp Met Ser Arg Arg

165 170 175Leu Glu Leu Ser

180<210>853<211>622<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (622)<223>FRXA00426<400>853attcgtgaac tcatggatct ttaggcaata aatgtgagat tggacgattt cacgcttgtc 60ttcaccacct gaaaattttc gggggtaacc tttaaaggcg atg aac agt tct cac 115

Met Asn Ser Ser His

1 5ggc acg tcc agc tcc ggc gct tcg gcc ggt gcc cac gga gcc ctt ccc 163Gly Thr Ser Ser Ser Gly Ala Ser Ala Gly Ala His Gly Ala Leu Pro

10 15 20cta gaa gct cag aaa ctg aac ggt tgg ggc cgc aca gcc ccc acc acc 211Leu Glu Ala Gln Lys Leu Asn Gly Trp Gly Arg Thr Ala Pro Thr Thr

25 30 35gct gag gta ctt acc acc cca gac cta gac atc att gtg gat gca gtc 259Ala Glu Val Leu Thr Thr Pro Asp Leu Asp Ile Ile Val Asp Ala Val

40 45 50cgc caa gtc gct gaa caa aac gac tcc aag ccg gac tac ctc aag cgc 307Arg Gln Val Ala Glu Gln Asn Asp Ser Lys Pro Asp Tyr Leu Lys Arg

55 60 65ggc gtg att gcc cgt ggc atg ggt cgt tcc tat ggt gac cca gcc caa 355Gly Val Ile Ala Arg Gly Met Gly Arg Ser Tyr Gly Asp Pro Ala Gln 70 75 80 85aac gcc ggt ggc ctt gtc att gac atg cag cca ctg aac aaa atc cac 403Asn Ala Gly Gly Leu Val Ile Asp Met Gln Pro Leu Asn Lys Ile His

90 95 100tcg att gat cct gat tct gcg atc gtc gat gta gat ggc ggc gtc acc 451Ser Ile Asp Pro Asp Ser Ala Ile Val Asp Val Asp Gly Gly Val Thr

105 110 115ctc gat cag ctc atg aag gct gcc ctg cca tat ggc ctc tgg gtt cct 499Leu Asp Gln Leu Met Lys Ala Ala Leu Pro Tyr Gly Leu Trp Val Pro

120 125 130gtc ctt ccc ggc acc cgc caa gtc acc atc ggt ggc gca atc gga cca 547Val Leu Pro Gly Thr Arg Gln Val Thr Ile Gly Gly Ala Ile Gly Pro

135 140 145gac atc cac ggt aag aac cac cac tct gca ggt tcc ttc ggc gac cac 595Asp Ile His Gly Lys Asn His His Ser Ala Gly Ser Phe Gly Asp His150 155 160 165gtg gtc tcc atg gaa ctc ctc gtt gca 622Val Val Ser Met Glu Leu Leu Val Ala

170<210>854<211>174<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>854Met Asn Ser Ser His Gly Thr Ser Ser Ser Gly Ala Ser Ala Gly Ala 151015 His Gly Ala Leu Pro Leu Glu Ala Gln Lys Leu Asn Gly Trp Gly Arg

20 25 30Thr Ala Pro Thr Thr Ala Glu Val Leu Thr Thr Pro Asp Leu Asp Ile

35 40 45Ile Val Asp Ala Val Arg Gln Val Ala Glu Gln Asn Asp Ser Lys Pro

50 55 60Asp Tyr Leu Lys Arg Gly Val Ile Ala Arg Gly Met Gly Arg Ser Tyr 65 70 75 80Gly Asp Pro Ala Gln Asn Ala Gly Gly Leu Val Ile Asp Met Gln Pro

85 9095Leu Asn Lys Ile His Ser Ile Asp Pro Asp Ser Ala Ile Val Asp Val

100 105 110Asp Gly Gly Val Thr Leu Asp Gln Leu Met Lys Ala Ala Leu Pro Tyr

115 120 125Gly Leu Trp Val Pro Val Leu Pro Gly Thr Arg Gln Val Thr Ile Gly

130 135 140Gly Ala Ile Gly Pro Asp Ile His Gly Lys Asn His His Ser Ala Gly145 150 155 160Ser Phe Gly Asp His Val Val Ser Met Glu Leu Leu Val Ala

165170<210>855<211>930<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). - (907)<223>RXN00708<400>855cctgcgtatc ggctgccttt ttgaattctt ttcctcctcg aggcctaacc ttcaattcct 60taccgatccc cttccctgaa gtttcgctaa cctggcgtac atg act ctt tcc ctt 115

Met Thr Leu Ser Leu

1 5cct cca att ggt ttc ggc acc gtt cat ctt gat ggc gca cct ggc gtt 163Pro Pro Ile Gly Phe Gly Thr Val His Leu Asp Gly Ala Pro Gly Val

10 15 20gaa gcc atc gct act gcc att gat gct ggt tac cgc ctc atc gac acc 211Glu Ala Ile Ala Thr Ala Ile Asp Ala Gly Tyr Arg Leu Ile Asp Thr

25 30 35gcg tac aac tat gaa aat gaa ggt acc gtg ggc aag gct gtc cgc gag 259Ala Tyr Asn Tyr Glu Asn Glu Gly Thr Val Gly Lys Ala Val Arg Glu

40 45 50tcg ggt gtc ccc cgc gag gaa ttg att gtt acc agt aag ctc cct ggc 307Ser Gly Val Pro Arg Glu Glu Leu Ile Val Thr Ser Lys Leu Pro Gly

55 60 65cgc ttc cat gct cgc gat cta gga cgc gtc cgc att gag gaa agt cta 355Arg Phe His Ala Arg Asp Leu Gly Arg Val Arg Ile Glu Glu Ser Leu 70 75 80 85tac cgc ctc aac tta gat tac atc gat ctc ctc ttg att cac tgg cct 403Tyr Arg Leu Asn Leu Asp Tyr Ile Asp Leu Leu Leu Ile His Trp Pro

90 95 100aat ccc agc aag gat ctc tac gtc gag gcg tgg gaa acg ctg att gaa 451Asn Pro Ser Lys Asp Leu Tyr Val Glu Ala Trp Glu Thr Leu Ile Glu

105 110 115gtc cgc gat gct ggc ctg gtc aag cac atc gga gtg tct aac ttc ctt 499Val Arg Asp Ala Gly Leu Val Lys His Ile Gly Val Ser Asn Phe Leu

120 125 130cca aat cac att gat cgc ctg cgc cgc gaa acc ggt gaa ctg ccg gcc 547Pro Asn His Ile Asp Arg Leu Arg Arg Glu Thr Gly Glu Leu Pro Ala

135 140 145gtt aac cag atc gag ttg cac ccc tat ttc ccg cag gtg gag cag gta 595Val Asn Gln Ile Glu Leu His Pro Tyr Phe Pro Gln Val Glu Gln Val150 155 160 165gat ttc cac gat gag ctg ggc atc att acc gag gcc tgg agc ccg ctc 643Asp Phe His Asp Glu Leu Gly Ile Ile Thr Glu Ala Trp Ser Pro Leu

170 175 180agc aac ggt cgc gga ctc gtc gaa gag cca ttg ctc aag gaa atc ggc 691Ser Asn Gly Arg Gly Leu Val Glu Glu Pro Leu Leu Lys Glu Ile Gly

185 190 195gag cgc tac ggg gtc ggc agc ggc gaa atc gcc ctc gct tgg cat cac 739Glu Arg Tyr Gly Val Gly Ser Gly Glu Ile Ala Leu Ala Trp His His

200 205 210gcc agg gga atc gtt ccg att cca cgc tcc acc aac ccg gcc agg cag 787Ala Arg Gly Ile Val Pro Ile Pro Arg Ser Thr Asn Pro Ala Arg Gln

215 220 225cgc agc aac ttg gag gcg gta aag att tcg ctt atc gac gaa gac gtc 835Arg Ser Asn Leu Glu Ala Val Lys Ile Ser Leu Ile Asp Glu Asp Val230 235 240 245cag gcg att acc gct ttg gcg cgc aaa aac ggc cgg atc aaa gat caa 883Gln Ala Ile Thr Ala Leu Ala Arg Lys Asn Gly Arg Ile Lys Asp Gln

250 255 260gat cca gcc gtc tat gaa gaa ttc tagatagtta catcaaggtt ccg 930Asp Pro Ala Val Tyr Glu Glu Phe

265<210>856<211>269<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>856Met Thr Leu Ser Leu Pro Pro Ile Gly Phe Gly Thr Val His Leu Asp 151015 Gly Ala Pro Gly Val Glu Ala Ile Ala Thr Ala Ile Asp Ala Gly Tyr

20 25 30Arg Leu Ile Asp Thr Ala Tyr Asn Tyr Glu Asn Glu Gly Thr Val Gly

35 40 45Lys Ala Val Arg Glu Ser Gly Val Pro Arg Glu Glu Leu Ile Val Thr

50 55 60Ser Lys Leu Pro Gly Arg Phe His Ala Arg Asp Leu Gly Arg Val Arg 65 70 75 80Ile Glu Glu Ser Leu Tyr Arg Leu Asn Leu Asp Tyr Ile Asp Leu Leu

85 90 95Leu Ile His Trp Pro Asn Pro Ser Lys Asp Leu Tyr Val Glu Ala Trp

100 105 110Glu Thr Leu Ile Glu Val Arg Asp Ala Gly Leu Val Lys His Ile Gly

115 120 125Val Ser Asn Phe Leu Pro Asn His Ile Asp Arg Leu Arg Arg Glu Thr

130 135 140Gly Glu Leu Pro Ala Val Asn Gln Ile Glu Leu His Pro Tyr Phe Pro145 150 155 160Gln Val Glu Gln Val Asp Phe His Asp Glu Leu Gly Ile Ile Thr Glu

165 170 175Ala Trp Ser Pro Leu Ser Asn Gly Arg Gly Leu Val Glu Glu Pro Leu

180 185 190Leu Lys Glu Ile Gly Glu Arg Tyr Gly Val Gly Ser Gly Glu Ile Ala

195 200 205Leu Ala Trp His His Ala Arg Gly Ile Val Pro Ile Pro Arg Ser Thr

210 215 220Asn Pro Ala Arg Gln Arg Ser Asn Leu Glu Ala Val Lys Ile Ser Leu225 230 235 240Ile Asp Glu Asp Val Gln Ala Ile Thr Ala Leu Ala Arg Lys Asn Gly

245 250 255Arg Ile Lys Asp Gln Asp Pro Ala Val Tyr Glu Glu Phe

260265<210>857<211>695<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1).<672)<223>FRXA00708<400>857acc gtg ggc aag gct gtc cgc gag tcg ggt gtc ccc cgc gag gaa ttg 48Thr Val Gly Lys Ala Val Arg Glu Ser Gly Val Pro Arg Glu Glu Leu 151015 att gtt acc agt aag ctc cct ggc cgc ttc cat gct cgc gat cta gga 96Ile Val Thr Ser Lys Leu Pro Gly Arg Phe His Ala Arg Asp Leu Gly

20 25 30cgc gtc cgc att gag gaa agt cta tac cgc ctc aac tta gat tac atc 144Arg Val Arg Ile Glu Glu Ser Leu Tyr Arg Leu Asn Leu Asp Tyr Ile

35 40 45gat ctc ctc ttg att cac tgg cct aat ccc agc aag gat ctc tac gtc 192Asp Leu Leu Leu Ile His Trp Pro Asn Pro Ser Lys Asp Leu Tyr Val

50 55 60gag gcg tgg gaa acg ctg att gaa gtc cgc gat gct ggc ctg gtc aag 240Glu Ala Trp Glu Thr Leu Ile Glu Val Arg Asp Ala Gly Leu Val Lys65 70 75 80cac atc gga gtg tct aac ttc ctt cca aat cac att gat cgc ctg cgc 288His Ile Gly Val Ser Asn Phe Leu Pro Asn His Ile Asp Arg Leu Arg

85 90 95cgc gaa acc ggt gaa ctg ccg gcc gtt aac cag atc gag ttg cac ccc 336Arg Glu Thr Gly Glu Leu Pro Ala Val Asn Gln Ile Glu Leu His Pro

100 105 110tat ttc ccg cag gtg gag cag gta gat ttc cac gat gag ctg ggc atc 384Tyr Phe Pro Gln Val Glu Gln Val Asp Phe His Asp Glu Leu Gly Ile

115 120 125att acc gag gcc tgg agc ccg ctc agc aac ggt cgc gga ctc gtc gaa 432Ile Thr Glu Ala Trp Ser Pro Leu Ser Asn Gly Arg Gly Leu Val Glu

130 135 140gag cca ttg ctc aag gaa atc ggc gag cgc tac ggg gtc ggc agc ggc 480Glu Pro Leu Leu Lys Glu Ile Gly Glu Arg Tyr Gly Val Gly Ser Gly145 150 155 160gaa atc gcc ctc gct tgg cat cac gcc agg gga atc gtt ccg att cca 528Glu Ile Ala Leu Ala Trp His His Ala Arg Gly Ile Val Pro Ile Pro

165 170 175cgc tcc acc aac ccg gcc agg cag cgc agc aac ttg gag gcg gta aag 576Arg Ser Thr Asn Pro Ala Arg Gln Arg Ser Asn Leu Glu Ala Val Lys

180 185 190att tcg ctt atc gac gaa gac gtc cag gcg att acc gct ttg gcg cgc 624Ile Ser Leu Ile Asp Glu Asp Val Gln Ala Ile Thr Ala Leu Ala Arg

195 200 205aaa aac ggc cgg atc aaa gat caa gat cca gcc gtc tat gaa gaa ttc 672Lys Asn Gly Arg Ile Lys Asp Gln Asp Pro Ala Val Tyr Glu Glu Phe

210215220 tagatagtta catcaaggtt ccg 695<210>858<211>224<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>858Thr Val Gly Lys Ala Val Arg Glu Ser Gly Val Pro Arg Glu Glu Leu 151015 Ile Val Thr Ser Lys Leu Pro Gly Arg Phe His Ala Arg Asp Leu Gly

20 25 30Arg Val Arg Ile Glu Glu Ser Leu Tyr Arg Leu Asn Leu Asp Tyr Ile

35 40 45Asp Leu Leu Leu Ile His Trp Pro Asn Pro Ser Lys Asp Leu Tyr Val

50 55 60Glu Ala Trp Glu Thr Leu Ile Glu Val Arg Asp Ala Gly Leu Val Lys 65 70 75 80His Ile Gly Val Ser Asn Phe Leu Pro Asn His Ile Asp Arg Leu Arg

85 90 95Arg Glu Thr Gly Glu Leu Pro Ala Val Asn Gln Ile Glu Leu His Pro

100 105 110Tyr Phe Pro Gln Val Glu Gln Val Asp Phe His Asp Glu Leu Gly Ile

115 120 125Ile Thr Glu Ala Trp Ser Pro Leu Ser Asn Gly Arg Gly Leu Val Glu

130 135 140Glu Pro Leu Leu Lys Glu Ile Gly Glu Arg Tyr Gly Val Gly Ser Gly145 150 155 160Glu Ile Ala Leu Ala Trp His His Ala Arg Gly Ile Val Pro Ile Pro

165 170 175Arg Ser Thr Asn Pro Ala Arg Gln Arg Ser Asn Leu Glu Ala Val Lys

180 185 190Ile Ser Leu Ile Asp Glu Asp Val Gln Ala Ile Thr Ala Leu Ala Arg

195 200 205Lys Asn Gly Arg Ile Lys Asp Gln Asp Pro Ala Val Tyr Glu Glu Phe

210215220<210>859<211>1038<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<1015)<223>RXA02373<400>859aaagtcatag ctcatggtaa ttcagtgtag ataggcgtac ggtgggctat ccaattcatc 60tcaacctaag gcgcattttg gtgcgcatca aggagaaaat atg tct gtt gtg ggt 115

Met Ser Val Val Gly

1 5acc ggc cta ttc ttt gga tcc ccg gag gaa gag cgg gat aag ttg atg 163Thr Gly Leu Phe Phe Gly Ser Pro Glu Glu Glu Arg Asp Lys Leu Met

10 15 20caa tct ttg atg gat cag aag aat aag ctt tcg aag tct gaa ggt atc 211Gln Ser Leu Met Asp Gln Lys Asn Lys Leu Ser Lys Ser Glu Gly Ile

25 30 35cca ttg gtc acc ttg aat gat gga aaa acc att cct cag ctt ggt ttt 259Pro Leu Val Thr Leu Asn Asp Gly Lys Thr Ile Pro Gln Leu Gly Phe

40 45 50ggt gtg ttc aag gta gat ccc gat gaa gca gag cgc gta gtt acc gaa 307Gly Val Phe Lys Val Asp Pro Asp Glu Ala Glu Arg Val Val Thr Glu

55 60 65gca ctt gag gta ggt tac cgc cac atc gat act gct gcg att tac ggc 355Ala Leu Glu Val Gly Tyr Arg His Ile Asp Thr Ala Ala Ile Tyr Gly 70 75 80 85aat gag gaa ggt gtc ggc cga gct att gct aag tcc ggc att cct cgt 403Asn Glu Glu Gly Val Gly Arg Ala Ile Ala Lys Ser Gly Ile Pro Arg

90 95 100gaa gag ctg ttt att act acc aag ttg tgg aac gat cgc cac ctg gat 451Glu Glu Leu Phe Ile Thr Thr Lys Leu Trp Asn Asp Arg His Leu Asp

105 110 115gta gaa gct gct ttt gag gag tct ctg cag aag ctg ggc ttg gat tat 499Val Glu Ala Ala Phe Glu Glu Ser Leu Gln Lys Leu Gly Leu Asp Tyr

120 125 130gta gat ctg tac ttg gtg cac tgg ccg gca ccg aag aac gat aat tat 547Val Asp Leu Tyr Leu Val His Trp Pro Ala Pro Lys Asn Asp Asn Tyr

135 140 145gtt gct gca tgg aag ggc ttg gaa aag ctc ggt gac cgt gct cgt tcc 595Val Ala Ala Trp Lys Gly Leu Glu Lys Leu Gly Asp Arg Ala Arg Ser150 155 160 165atc ggt gtg tgc aac ttc ctg cca gag cac cta gaa aag ctg ctg gca 643Ile Gly Val Cys Asn Phe Leu Pro Glu His Leu Glu Lys Leu Leu Ala

170 175 180gag gca acc act gtg cct gcc att aac cag att gag ctg cac cca gct 691Glu Ala Thr Thr Val Pro Ala Ile Asn Gln Ile Glu Leu His Pro Ala

185 190 195ttg cag cag cgc gat gct gtt gag gca tct ctt gca gca ggc atc act 739Leu Gln Gln Arg Asp Ala Val Glu Ala Ser Leu Ala Ala Gly Ile Thr

200 205 210gtg gag tcg tgg ggt cct ctg gga cag ggg cgt ttt gat ctt ggc gct 787Val Glu Ser Trp Gly Pro Leu Gly Gln Gly Arg Phe Asp Leu Gly Ala

215 220 225gag gaa cca atc gca gct gca gcg aag aac cat gga aag acc cca gct 835Glu Glu Pro Ile Ala Ala Ala Ala Lys Asn His Gly Lys Thr Pro Ala230235 240 245cag gtt gtt atc cgt tgg cac ctg cag aac ggt ttc gtt gtg ttc ccc 883Gln Val Val Ile Arg Trp His Leu Gln Asn Gly Phe Val Val Phe Pro

250 255 260aag act gtg act aag agc cgc atg gtg gaa aac atc gac gtg ttt gat 931Lys Thr Val Thr Lys Ser Arg Met Val Glu Asn Ile Asp Val Phe Asp

265 270 275ttc gaa ctc agt gat gag gag atg gct gcg atc act gct ctt gag cgc 979Phe Glu Leu Ser Asp Glu Glu Met Ala Ala Ile Thr Ala Leu Glu Arg

280 285 290aat gat cgt ggt ggt tca cac ccg aat gat ctg aac tagaaataag 1025Asn Asp Arg Gly Gly Ser His Pro Asn Asp Leu Asn

295300305 gtaaggccct gca 1038<210>860<211>305<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>860Met Ser Val Val Gly Thr Gly Leu Phe Phe Gly Ser Pro Glu Glu Glu 151015 Arg Asp Lys Leu Met Gln Ser Leu Met Asp Gln Lys Asn Lys Leu Ser

20 25 30Lys Ser Glu Gly Ile Pro Leu Val Thr Leu Asn Asp Gly Lys Thr Ile

35 40 45Pro Gln Leu Gly Phe Gly Val Phe Lys Val Asp Pro Asp Glu Ala Glu

50 55 60Arg Val Val Thr Glu Ala Leu Glu Val Gly Tyr Arg His Ile Asp Thr 65 70 75 80Ala Ala Ile Tyr Gly Asn Glu Glu Gly Val Gly Arg Ala Ile Ala Lys

85 90 95Ser Gly Ile Pro Arg Glu Glu Leu Phe Ile Thr Thr Lys Leu Trp Asn

100 105 110Asp Arg His Leu Asp Val Glu Ala Ala Phe Glu GluSer Leu Gln Lys

115 120 125Leu Gly Leu Asp Tyr Val Asp Leu Tyr Leu Val His Trp Pro Ala Pro

130 135 140Lys Asn Asp Asn Tyr Val Ala Ala Trp Lys Gly Leu Glu Lys Leu Gly145 150 155 160Asp Arg Ala Arg Ser Ile Gly Val Cys Asn Phe Leu Pro Glu His Leu

165 170 175Glu Lys Leu Leu Ala Glu Ala Thr Thr Val Pro Ala Ile Asn Gln Ile

180 185 190Glu Leu His Pro Ala Leu Gln Gln Arg Asp Ala Val Glu Ala Ser Leu

195 200 205Ala Ala Gly Ile Thr Val Glu Ser Trp Gly Pro Leu Gly Gln Gly Arg

210 215 220Phe Asp Leu Gly Ala Glu Glu Pro Ile Ala Ala Ala Ala Lys Asn His225 230 235 240 Gly Lys Thr Pro Ala Gln Val Val Ile Arg Trp His Leu Gln Asn Gly

245 250 255Phe Val Val Phe Pro Lys Thr Val Thr Lys Ser Arg Met Val Glu Asn

260 265 270Ile Asp Val Phe Asp Phe Glu Leu Ser Asp Glu Glu Met Ala Ala Ile

275 280 285Thr Ala Leu Glu Arg Asn Asp Arg Gly Gly Ser His Pro Asn Asp Leu

290295300 Asn305<210>861<211>1683<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1660)<223>RXS00389<400>861ccaccactgc gtaacctttc cgagcaagat atcgcggacc tgtcggattt gcttgccacc 60tctggcgcag gttcctaccg ccttcagttg aggtgaaagc atg atc acc gca acc 115

Met Ile Thr Ala Thr

1 5gca ctg cat ggg tgt tca ctg att gat ggc gag tgg gtc gct gga aaa 163Ala Leu His Gly Cys Ser Leu Ile Asp Gly Glu Trp Val Ala Gly Lys

10 15 20aat ggt gag att aca gga ttc gat ccg cgc acc aat gcg agt ctg aac 211Asn Gly Glu Ile Thr Gly Phe Asp Pro Arg Thr Asn Ala Ser Leu Asn

25 30 35cct tcc tac tct tta gca aac agc gca cag ctg cgc gcc gcc aca aca 259Pro Ser Tyr Ser Leu Ala Asn Ser Ala Gln Leu Arg Ala Ala Thr Thr

40 45 50tcg gcg aag cga gct ttt gaa agc tac cga ctc act act cca gag gtt 307Ser Ala Lys Arg Ala Phe Glu Ser Tyr Arg Leu Thr Thr Pro Glu Val

55 60 65aga gca gat ttc ctg gat tcc atc gct gac aac atc gat gcg cta tcc 355Arg Ala Asp Phe Leu Asp Ser Ile Ala Asp Asn Ile Asp Ala Leu Ser 70 75 80 85ggc gag atc gtg caa cgg gcg agc ctg gag aca ggt ttg gga act acc 403Gly Glu Ile Val Gln Arg Ala Ser Leu Glu Thr Gly Leu Gly Thr Thr

90 95 100cga ctc aca ggc gaa gta gcc cgc acc agc aac cag ctc cgc ctg ttt 451Arg Leu Thr Gly Glu Val Ala Arg Thr Ser Asn Gln Leu Arg Leu Phe

105 110 115gca gaa acc gtg aga agc gga cag ttc cac cga gta cgc att gaa cga 499Ala Glu Thr Val Arg Ser Gly Gln Phe His Arg Val Arg Ile Glu Arg

120 125 130gga ccg cgg att gat ctt cgc cag cgt cag gtt ccg ttg gga cca gtc 547Gly Pro Arg Ile Asp Leu Arg Gln Arg Gln Val Pro Leu Gly Pro Val

135 140 145gcg gta ttc ggg gca agc aac ttc ccc gtc gct ttc tct act gct ggt 595Ala Val Phe Gly Ala Ser Asn Phe Pro Val Ala Phe Ser Thr Ala Gly150 155 160 165ggc gat aca gca tca gcg ttg gct gca ggc tgc cct gtg gtt ttt aag 643Gly Asp Thr Ala Ser Ala Leu Ala Ala Gly Cys Pro Val Val Phe Lys

170 175 180gcg cat aat gcg cac cct gga aca gct gag ctc gtc ggg caa gcg gtg 691Ala His Asn Ala His Pro Gly Thr Ala Glu Leu Val Gly Gln Ala Val

185 190 195cgg gga gcc gtc gaa aag cat gag ttt gat gct ggt gtg ttt aac ctt 739Arg Gly Ala Val Glu Lys His Glu Phe Asp Ala Gly Val Phe Asn Leu

200 205 210gtc tac ggc cgt ggc gtg gaa att ggc cag gag ctg gct gcg gat ccg 787Val Tyr Gly Arg Gly Val Glu Ile Gly Gln Glu Leu Ala Ala Asp Pro

215 220 225aat atc acg gca atc ggt ttt acc ggt tca cgc cag ggt ggt ttg gca 835Asn Ile Thr Ala Ile Gly Phe Thr Gly Ser Arg Gln Gly Gly Leu Ala230 235 240 245ctg tca cag act gcg ttt agc cgc cca gtt ccc gtt cca gtc ttt gca 883Leu Ser Gln Thr Ala Phe Ser Arg Pro Val Pro Val Pro Val Phe Ala

250 255 260gaa atg agt gcc acc aac cct gtg ttc gtc ttc ccc ggc gcg ctg gcg 931Glu Met Ser Ala Thr Asn Pro Val Phe Val Phe Pro Gly Ala Leu Ala

265 270 275gat ttg gat gca tcg agt tcc ttg gct gag gcg ttt acc gct tcc gtc 979Asp Leu Asp Ala Ser Ser Ser Leu Ala Glu Ala Phe Thr Ala Ser Val

280 285 290acc ggc agt tcc ggg caa ttg tgc acc aag cct ggc ctc gtt ttc atc 1027Thr Gly Ser Ser Gly Gln Leu Cys Thr Lys Pro Gly Leu Val Phe Ile

295 300 305ccg cgc ggt gtt gtt ggt gat gct ttt gtg gcg ctc gta gca gcc aaa 1075Pro Arg Gly Val Val Gly Asp Ala Phe Val Ala Leu Val Ala Ala Lys310 315 320 325ttt aaa gaa acc acg ggt caa acg atg ctc acg caa ggc atc gct cag 1123Phe Lys Glu Thr Thr Gly Gln Thr Met Leu Thr Gln Gly Ile Ala Gln

330 335 340gca tgg cag cgc gga gtc gac aac ctt gca gca cag cca agt gta aaa 1171Ala Trp Gln Arg Gly Val Asp Asn Leu Ala Ala Gln Pro Ser Val Lys

345 350 355atc ctc gcc caa ggc acc ccc gga gat gga gag aac gcg ccg ggc ccg 1219Ile Leu Ala Gln Gly Thr Pro Gly Asp Gly Glu Asn Ala Pro Gly Pro

360 365 370gtg gtg ttt gaa agt gat gtg cag gcg ttg cta aat aat gtg gtg ttg 1267Val Val Phe Glu Ser Asp Val Gln Ala Leu Leu Asn Asn Val Val Leu

375 380 385cag gaa gaa atc ttc ggt gcg gca tcg ctg gtg gtg cgt tat gat tcc 1315Gln Glu Glu Ile Phe Gly Ala Ala Ser Leu Val Val Arg Tyr Asp Ser390 395 400 405ccg gat caa ctc cac caa gta gcc aat tca ctc gag gga caa tta aca 1363Pro Asp Gln Leu His Gln Val Ala Asn Ser Leu Glu Gly Gln Leu Thr

410 415 420gcc acg atc cac gca tcc cag gat gat ttc cag gaa gtc tcg aaa ctt 1411Ala Thr Ile His Ala Ser Gln Asp Asp Phe Gln Glu Val Ser Lys Leu

425 430 435atc ccc ctc ttg gag gat ctc gcg ggc cgt gtt ctt tac ggc ggc tgg 1459Ile Pro Leu Leu Glu Asp Leu Ala Gly Arg Val Leu Tyr Gly Gly Trp

440 445 450cca acg ggt gtg gaa gtt ggg cac acg gtt atc cat gga ggc cct tat 1507Pro Thr Gly Val Glu Val Gly His Thr Val Ile His Gly Gly Pro Tyr

455 460 465ccg gcg acc tca aat gcg cag tcg aca agt gtt gga acc ctg gca atc 1555Pro Ala Thr Ser Asn Ala Gln Ser Thr Ser Val Gly Thr Leu Ala Ile470 475 480 485gag aga ttt atg cgc ccg gtt tct tat caa act ttc ccg gct gag ctg 1603Glu Arg Phe Met Arg Pro Val Ser Tyr Gln Thr Phe Pro Ala Glu Leu

490 495 500ctt cca gat cca gtt tct gag gcg aat aaa tgg gct gta cct cgg gaa 1651Leu Pro Asp Pro Val Ser Glu Ala Asn Lys Trp Ala Val Pro Arg Glu

505 510 515ata gac cgt taatagctgg tctttacatt tgc 1683Ile Asp Arg

520<210>862<211>520<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>862Met Ile Thr Ala Thr Ala Leu His Gly Cys Ser Leu Ile Asp Gly Glu 151015 Trp Val Ala Gly Lys Asn Gly Glu Ile Thr Gly Phe Asp Pro Arg Thr

20 25 30Asn Ala Ser Leu Asn Pro Ser Tyr Ser Leu Ala Asn Ser Ala Gln Leu

35 40 45Arg Ala Ala Thr Thr Ser Ala Lys Arg Ala Phe Glu Ser Tyr Arg Leu

50 55 60Thr Thr Pro Glu Val Arg Ala Asp Phe Leu Asp Ser Ile Ala Asp Asn 65 70 75 80Ile Asp Ala Leu Ser Gly Glu Ile Val Gln Arg Ala Ser Leu Glu Thr

8590 95Gly Leu Gly Thr Thr Arg Leu Thr Gly Glu Val Ala Arg Thr Ser Asn

100 105 110Gln Leu Arg Leu Phe Ala Glu Thr Val Arg Ser Gly Gln Phe His Arg

115 120 125Val Arg Ile Glu Arg Gly Pro Arg Ile Asp Leu Arg Gln Arg Gln Val

130 135 140Pro Leu Gly Pro Val Ala Val Phe Gly Ala Ser Asn Phe Pro Val Ala145 150 155 160Phe Ser Thr Ala Gly Gly Asp Thr Ala Ser Ala Leu Ala Ala Gly Cys

165 170 175Pro Val Val Phe Lys Ala His Asn Ala His Pro Gly Thr Ala Glu Leu

180 185 190Val Gly Gln Ala Val Arg Gly Ala Val Glu Lys His Glu Phe Asp Ala

195 200 205Gly Val Phe Asn Leu Val Tyr Gly Arg Gly Val Glu Ile Gly Gln Glu

210 215 220Leu Ala Ala Asp Pro Asn Ile Thr Ala Ile Gly Phe Thr Gly Ser Arg225 230 235 240Gln Gly Gly Leu Ala Leu Ser Gln Thr Ala Phe Ser Arg Pro Val Pro

245 250 255Val Pro Val Phe Ala Glu Met Ser Ala Thr Asn Pro Val Phe Val Phe

260 265 270Pro Gly Ala Leu Ala Asp Leu Asp Ala Ser Ser Ser Leu Ala Glu Ala

275 280 285Phe Thr Ala Ser Val Thr Gly Ser Ser Gly Gln Leu Cys Thr Lys Pro

290 295 300Gly Leu Val Phe Ile Pro Arg Gly Val Val Gly Asp Ala Phe Val Ala305 310315 320Leu Val Ala Ala Lys Phe Lys Glu Thr Thr Gly Gln Thr Met Leu Thr

325 330 335Gln Gly Ile Ala Gln Ala Trp Gln Arg Gly Val Asp Asn Leu Ala Ala

340 345 350Gln Pro Ser Val Lys Ile Leu Ala Gln Gly Thr Pro Gly Asp Gly Glu

355 360 365Asn Ala Pro Gly Pro Val Val Phe Glu Ser Asp Val Gln Ala Leu Leu

370 375 380Asn Asn Val Val Leu Gln Glu Glu Ile Phe Gly Ala Ala Ser Leu Val385 390 395 400Val Arg Tyr Asp Ser Pro Asp Gln Leu His Gln Val Ala Asn Ser Leu

405 410 415Glu Gly Gln Leu Thr Ala Thr Ile His Ala Ser Gln Asp Asp Phe Gln

420 425 430Glu Val Ser Lys Leu Ile Pro Leu Leu Glu Asp Leu Ala Gly Arg Val

435 440 445Leu Tyr Gly Gly Trp Pro Thr Gly Val Glu Val Gly His Thr Val Ile

450 455 460His Gly Gly Pro Tyr Pro Ala Thr Ser Asn Ala Gln Ser Thr Ser Val465 470 475 480Gly Thr Leu Ala Ile Glu Arg Phe Met Arg Pro Val Ser Tyr Gln Thr

485 490 495Phe Pro Ala Glu Leu Leu Pro Asp Pro Val Ser Glu Ala Asn Lys Trp

500 505 510Ala Val Pro Arg Glu Ile Asp Arg

515520<210>863<211>882<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (859)<223>RXS00419<400>863gctggttgaa gactcgaaat gagatcgacc caaccggagt ctttgcatct gacatgtccc 60gccgacttga gctttcttaa gaaagggctt gaactaaaca atg ctt aac gca gtg 115

Met Leu Asn Ala Val

1 5ggc aaa gcc caa aac att ctc ctt ctt ggt gga acc tct gag atc ggt 163Gly Lys Ala Gln Asn Ile Leu Leu Leu Gly Gly Thr Ser Glu Ile Gly

10 15 20att tcc att gtc tcc cgc ttc ctc aag cag ggt cca tcc cat gtg acc 211Ile Ser Ile Val Ser Arg Phe Leu Lys Gln Gly Pro Ser His Val Thr

25 30 35ttg gca gcg cgt aaa gat tcc cca cgc gtg gac gca gca gtc gca gag 259Leu Ala Ala Arg Lys Asp Ser Pro Arg Val Asp Ala Ala Val Ala Glu

40 45 50atc aaa gca gct ggc gct gct tcc gtt gct gtt gtt gat ttc gat gcg 307Ile Lys Ala Ala Gly Ala Ala Ser Val Ala Val Val Asp Phe Asp Ala

55 60 65ctc gac acc gaa tcc cac cct gca gcc atc gac gca gcc ttt gaa aac 355Leu Asp Thr Glu Ser His Pro Ala Ala Ile Asp Ala Ala Phe Glu Asn 70 75 80 85ggc gac gtt gac gta gca atc gtg gct ttc ggc atc ctc ggc gac aac 403Gly Asp Val Asp Val Ala Ile Val Ala Phe Gly Ile Leu Gly Asp Asn

90 95 100gaa gca cag tgg cgc gac caa gca cta gca gtg gaa gca acc acc gtg 451Glu Ala Gln Trp Arg Asp Gln Ala Leu Ala Val Glu Ala Thr Thr Val

105 110 115aac tac acc gcc ggc gtt tcc gta ggt gta ctg ctg ggc cag aaa ttt 499Asn Tyr Thr Ala Gly Val Ser Val Gly Val Leu Leu Gly Gln Lys Phe

120 125 130gag cag cag ggc cac ggc acc atc gtg gca ttg tcc tct gtg gca ggc 547Glu Gln Gln Gly His Gly Thr Ile Val Ala Leu Ser Ser Val Ala Gly

135 140 145cag cga gtc cgc cgc tcc aac ttt gtc tac ggc tcc gcc aag gca ggt 595Gln Arg Val Arg Arg Ser Asn Phe Val Tyr Gly Ser Ala Lys Ala Gly150 155 160 165ttc gac ggt ttc tac acc cag ctc ggc gaa gcc ctg cgt gga tcc ggt 643Phe Asp Gly Phe Tyr Thr Gln Leu Gly Glu Ala Leu Arg Gly Ser Gly

170 175 180gcc aac gta ttg gtg gtt cgc cca ggc cag gta cgc acc aag atg tcc 691Ala Asn Val Leu Val Val Arg Pro Gly Gln Val Arg Thr Lys Met Ser

185 190 195gca gat ggt ggc gaa gcc cca ctg acc gtc aac cgc gaa gac gtg gca 739Ala Asp Gly Gly Glu Ala Pro Leu Thr Val Asn Arg Glu Asp Val Ala

200 205 210gat gct gtt tat gat gca gtg gtg aac aag aag gac atc atc ttt gtc 787Asp Ala Val Tyr Asp Ala Val Val Asn Lys Lys Asp Ile Ile Phe Val

215 220 225cac cca ctg ttc cag tac gtc tct ttt gcg ttc caa ttc att ccg cga 835His Pro Leu Phe Gln Tyr Val Ser Phe Ala Phe Gln Phe Ile Pro Arg230 235 240 245gca atc ttc cgc aag ctg ccg ttc taacggaagt tacggaagtt acg 882Ala Ile Phe Arg Lys Leu Pro Phe

250<210>864<211>253<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>864Met Leu Asn Ala Val Gly Lys Ala Gln Asn Ile Leu Leu Leu Gly Gly 151015 Thr Ser Glu Ile Gly Ile Ser Ile Val Ser Arg Phe Leu Lys Gln Gly

2025 30Pro Ser His Val Thr Leu Ala Ala Arg Lys Asp Ser Pro Arg Val Asp

35 40 45Ala Ala Val Ala Glu Ile Lys Ala Ala Gly Ala Ala Ser Val Ala Val

50 55 60Val Asp Phe Asp Ala Leu Asp Thr Glu Ser His Pro Ala Ala Ile Asp 65 70 75 80Ala Ala Phe Glu Asn Gly Asp Val Asp Val Ala Ile Val Ala Phe Gly

85 90 95Ile Leu Gly Asp Asn Glu Ala Gln Trp Arg Asp Gln Ala Leu Ala Val

100 105 110Glu Ala Thr Thr Val Asn Tyr Thr Ala Gly Val Ser Val Gly Val Leu

115 120 125Leu Gly Gln Lys Phe Glu Gln Gln Gly His Gly Thr Ile Val Ala Leu

130 135 140Ser Ser Val Ala Gly Gln Arg Val Arg Arg Ser Asn Phe Val Tyr Gly145 150 155 160Ser Ala Lys Ala Gly Phe Asp Gly Phe Tyr Thr Gln Leu Gly Glu Ala

165 170 175Leu Arg Gly Ser Gly Ala Asn Val Leu Val Val Arg Pro Gly Gln Val

180 185 190Arg Thr Lys Met Ser Ala Asp Gly Gly Glu Ala Pro Leu Thr Val Asn

195 200 205Arg Glu Asp Val Ala Asp Ala Val Tyr Asp Ala Val Val Asn Lys Lys

210 215 220Asp Ile Ile Phe Val His Pro Leu Phe Gln Tyr Val Ser Phe Ala Phe225 230 235 240Gln Phe Ile Pro Arg Ala Ile Phe Arg Lys Leu Pro Phe

245250<210>865<211>1673<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220>CDS<222>(1).<1650)<223>RXC00416<400>865ctg gcg tct tac tta agc cca act gcg ctg gtg gtt gcg gtg ttg gct 48Leu Ala Ser Tyr Leu Ser Pro Thr Ala Leu Val Val Ala Val Leu Ala 151015 att ccg ctg tct gcg acc cgc ctg tat ttg gac gga atc agc gtt gac 96Ile Pro Leu Ser Ala Thr Arg Leu Tyr Leu Asp Gly Ile Ser Val Asp

20 25 30cag ggc ttt aga act cag ttt tta acc cgc atg gct gac gat atc ggc 144Gln Gly Phe Arg Thr Gln Phe Leu Thr Arg Met Ala Asp Asp Ile Gly

35 40 45ttg tcg gac atg aac tac atc gat atg cct acc ttc tac cct gct gga 192Leu Ser Asp Met Asn Tyr Ile Asp Met Pro Thr Phe Tyr Pro Ala Gly

50 55 60tgg ttc tgg ctc ggt ggt cgc ttg gcc aat ctt ttg ggg ctg ccc ggt 240Trp Phe Trp Leu Gly Gly Arg Leu Ala Asn Leu Leu Gly Leu Pro Gly 65 70 75 80tgg gaa gct ttc cag cca tgg gca att gtg tcc atg gca gtt gct gct 288Trp Glu Ala Phe Gln Pro Trp Ala Ile Val Ser Met Ala Val Ala Ala

85 90 95tct gtg tta gtt cca gtg tgg cag cgc atc acc ggt tcc ctg ccg gtg 336Ser Val Leu Val Pro Val Trp Gln Arg Ile Thr Gly Ser Leu Pro Val

100 105 110gca aca ggc att gcg ttg gtg aca acc tgc att atc ttg gcg atg aat 384Ala Thr Gly Ile Ala Leu Val Thr Thr Cys Ile Ile Leu Ala Met Asn

115 120 125tcc gaa gag ccc tac gct gca atc gtt gcg atg ggt att cca gcg atg 432Ser Glu Glu Pro Tyr Ala Ala Ile Val Ala Met Gly Ile Pro Ala Met

130 135140ctc gtg ctg gct tcc cgc att gcc aag ggc gat aag ttt gcg ctt gcc 480Leu Val Leu Ala Ser Arg Ile Ala Lys Gly Asp Lys Phe Ala Leu Ala145 150 155 160ggc ggc att att tac ttg ggt gtt tcg gct act ttc tat act ttg ttc 528Gly Gly Ile Ile Tyr Leu Gly Val Ser Ala Thr Phe Tyr Thr Leu Phe

165 170 175acc ggt gct atc gcg ctt tct gcg gtc gcg gtg tgc atc gtg gtg gcg 576Thr Gly Ala Ile Ala Leu Ser Ala Val Ala Val Cys Ile Val Val Ala

180 185 190gct att gtg cag cgc tcc atc aaa cca ctg ctg tgg ctt gca gtg ctg 624Ala Ile Val Gln Arg Ser Ile Lys Pro Leu Leu Trp Leu Ala Val Leu

195 200 205ggt ggt gga tcc att gtc att gcg ttg att tct tgg ggt cct tac ctt 672Gly Gly Gly Ser Ile Val Ile Ala Leu Ile Ser Trp Gly Pro Tyr Leu

210 215 220ctg gcc tcc atc aac gga gcg gag cgc tct ggc gat tcc gca aca cac 720Leu Ala Ser Ile Asn Gly Ala Glu Arg Ser Gly Asp Ser Ala Thr His225 230 235 240tac ctg cct ctt gaa ggc acc caa ttc ccg gtt cct ttc ttg gca tca 768Tyr Leu Pro Leu Glu Gly Thr Gln Phe Pro Val Pro Phe Leu Ala Ser

245 250 255agc gtt gtg gga ctg ttg tgt ctt gtt ggc ctg atc tat ttg gtg gtg 816Ser Val Val Gly Leu Leu Cys Leu Val Gly Leu Ile Tyr Leu Val Val

260 265 270cgt ttc cac aac aat gag gtg cgc gcg atg tgg gtc ggc atc gca gtg 864Arg Phe His Asn Asn Glu Val Arg Ala Met Trp Val Gly Ile Ala Val

275 280 285ttt tat gcc tgg atg ggc atg tcc atg gcg atc acg ctt ttg ggc aac 912Phe Tyr Ala TrpMet Gly Met Ser Met Ala Ile Thr Leu Leu Gly Asn

290 295 300acg ttg ctt gga ttc cgt ctt gat acg gtg ctg gtg ctt att ttt gcc 960Thr Leu Leu Gly Phe Arg Leu Asp Thr Val Leu Val Leu Ile Phe Ala305 310 315 320acg gct gga gtg ttg ggc att gca gat ttc cgc ctt gcc agt gtg tat 1008Thr Ala Gly Val Leu Gly Ile Ala Asp Phe Arg Leu Ala Ser Val Tyr

325 330 335cag ctc tac ccc acc caa atc aca gag cgc acg gcc acc cat ctg acc 1056Gln Leu Tyr Pro Thr Gln Ile Thr Glu Arg Thr Ala Thr His Leu Thr

340 345 350aat cta att gtg gtc ctc gtg ctg ctt ggc ggc ctc tac tac gcg caa 1104Asn Leu Ile Val Val Leu Val Leu Leu Gly Gly Leu Tyr Tyr Ala Gln

355 360 365gat ctg ccg cag aag aac gca cga gct atc gat ctg gcc tat acc gat 1152Asp Leu Pro Gln Lys Asn Ala Arg Ala Ile Asp Leu Ala Tyr Thr Asp

370 375 380act gat ggc tac ggc gag cgc gcg gat ctg tat ccg gcc gga gct gca 1200Thr Asp Gly Tyr Gly Glu Arg Ala Asp Leu Tyr Pro Ala Gly Ala Ala385 390 395 400cgt tat tac aag gac atc aac gat cat ctg ctt gat caa gga ttc gag 1248Arg Tyr Tyr Lys Asp Ile Asn Asp His Leu Leu Asp Gln Gly Phe Glu

405 410 415cct tcc gaa act gtc gtg ctg aca gac gaa ctc gat ttc atg tcc tac 1296Pro Ser Glu Thr Val Val Leu Thr Asp Glu Leu Asp Phe Met Ser Tyr

420 425 430tac cct tat cgc gga tac caa gct ttt act tcc cac tac gcc aac ccg 1344Tyr Pro Tyr Arg Gly Tyr Gln Ala Phe Thr Ser His Tyr Ala Asn Pro

435 440 445ctt ggt gag ttc gga aac agg aac gca ttc atc gaa gat ctc gcg atc 1392Leu Gly Glu Phe Gly Asn Arg Asn Ala Phe Ile Glu Asp Leu Ala Ile

450 455 460cga agc tgg gat gag ttg gct gat cct caa caa ttc agc gac gcc ttg 1440Arg Ser Trp Asp Glu Leu Ala Asp Pro Gln Gln Phe Ser Asp Ala Leu465 470 475 480aac acc tct cca tgg acg atc cct gag gtg ttc atc ttc cgt ggc tcc 1488Asn Thr Ser Pro Trp Thr Ile Pro Glu Val Phe Ile Phe Arg Gly Ser

485 490 495atc gat gat cct gac gcc ggt tgg aaa tac gac gtg gct gaa gat ctg 1536Ile Asp Asp Pro Asp Ala Gly Trp Lys Tyr Asp Val Ala Glu Asp Leu

500 505 510tac ccg aac aat cca aac gtg cgc ttc cgc ggc gtg tac ttt aac ccg 1584Tyr Pro Asn Asn Pro Asn Val Arg Phe Arg Gly Val Tyr Phe Asn Pro

515 520 525gag tca ttt gat cag atg tgg cag acc aag caa gtg gga cct ttc gtg 1632Glu Ser Phe Asp Gln Met Trp Gln Thr Lys Gln Val Gly Pro Phe Val

530535540 gtg gta acg cac aat gag taattcctca ccaaacgacc caa 1673Val Val Thr His Asn Glu 545550<210>866<211>550<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>866Leu Ala Ser Tyr Leu Ser Pro Thr Ala Leu Val Val Ala Val Leu Ala 151015 Ile Pro Leu Ser Ala Thr Arg Leu Tyr Leu Asp Gly Ile Ser Val Asp

20 25 30Gln Gly Phe Arg Thr Gln Phe Leu Thr Arg Met Ala Asp Asp Ile Gly

35 40 45 Leu Ser Asp Met Asn Tyr Ile Asp Met Pro Thr Phe Tyr Pro Ala Gly

50 5560Trp Phe Trp Leu Gly Gly Arg Leu Ala Asn Leu Leu Gly Leu Pro Gly 65 70 75 80Trp Glu Ala Phe Gln Pro Trp Ala Ile Val Ser Met Ala Val Ala Ala

85 90 95Ser Val Leu Val Pro Val Trp Gln Arg Ile Thr Gly Ser Leu Pro Val

100 105 110Ala Thr Gly Ile Ala Leu Val Thr Thr Cys Ile Ile Leu Ala Met Asn

115 120 125Ser Glu Glu Pro Tyr Ala Ala Ile Val Ala Met Gly Ile Pro Ala Met

130 135 140Leu Val Leu Ala Ser Arg Ile Ala Lys Gly Asp Lys Phe Ala Leu Ala145 150 155 160Gly Gly Ile Ile Tyr Leu Gly Val Ser Ala Thr Phe Tyr Thr Leu Phe

165 170 175Thr Gly Ala Ile Ala Leu Ser Ala Val Ala Val Cys Ile Val Val Ala

180 185 190Ala Ile Val Gln Arg Ser Ile Lys Pro Leu Leu Trp Leu Ala Val Leu

195 200 205Gly Gly Gly Ser Ile Val Ile Ala Leu Ile Ser Trp Gly Pro Tyr Leu

210 215 220Leu Ala Ser Ile Asn Gly Ala Glu Arg Ser Gly Asp Ser Ala Thr His225 230 235 240Tyr Leu Pro Leu Glu Gly Thr Gln Phe Pro Val Pro Phe Leu Ala Ser

245 250 255Ser Val Val Gly Leu Leu Cys Leu Val Gly Leu Ile Tyr Leu Val Val

260 265 270Arg Phe His Asn Asn Glu Val Arg Ala Met Trp Val Gly Ile Ala Val

275 280285Phe Tyr Ala Trp Met Gly Met Ser Met Ala Ile Thr Leu Leu Gly Asn

290 295 300Thr Leu Leu Gly Phe Arg Leu Asp Thr Val Leu Val Leu Ile Phe Ala305 310 315 320Thr Ala Gly Val Leu Gly Ile Ala Asp Phe Arg Leu Ala Ser Val Tyr

325 330 335Gln Leu Tyr Pro Thr Gln Ile Thr Glu Arg Thr Ala Thr His Leu Thr

340 345 350Asn Leu Ile Val Val Leu Val Leu Leu Gly Gly Leu Tyr Tyr Ala Gln

355 360 365Asp Leu Pro Gln Lys Asn Ala Arg Ala Ile Asp Leu Ala Tyr Thr Asp

370 375 380Thr Asp Gly Tyr Gly Glu Arg Ala Asp Leu Tyr Pro Ala Gly Ala Ala385 390 395 400Arg Tyr Tyr Lys Asp Ile Asn Asp His Leu Leu Asp Gln Gly Phe Glu

405 410 415Pro Ser Glu Thr Val Val Leu Thr Asp Glu Leu Asp Phe Met Ser Tyr

420 425 430Tyr Pro Tyr Arg Gly Tyr Gln Ala Phe Thr Ser His Tyr Ala Asn Pro

435 440 445Leu Gly Glu Phe Gly Asn Arg Asn Ala Phe Ile Glu Asp Leu Ala Ile

450 455 460Arg Ser Trp Asp Glu Leu Ala Asp Pro Gln Gln Phe Ser Asp Ala Leu465 470 475 480Asn Thr Ser Pro Trp Thr Ile Pro Glu Val Phe Ile Phe Arg Gly Ser

485 490 495Ile Asp Asp Pro Asp Ala Gly Trp Lys Tyr Asp Val Ala Glu Asp Leu

500505 510Tyr Pro Asn Asn Pro Asn Val Arg Phe Arg Gly Val Tyr Phe Asn Pro

515 520 525Glu Ser Phe Asp Gln Met Trp Gln Thr Lys Gln Val Gly Pro Phe Val

530535540 Val Val Thr His Asn Glu 545550<210>867<211>1059<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1036)<223>RXC02206<400>867ggcaggatct gctgctgcgg ctaggagggt tatctcttca ttcacccgat ctaccgtact 60accttatgac ctcagtagtg tggtgggcgt gaaacagcga atg gtc ggt tca agt 115

Met Val Gly Ser Ser

1 5ggt ttg cgg gta tcc agg ctc ggt ttg ggc acc tca aca tgg ggc tcg 163Gly Leu Arg Val Ser Arg Leu Gly Leu Gly Thr Ser Thr Trp Gly Ser

10 15 20ggc acc gag ctg gct gag gca ggc gat atc ttt aag gcg ttc atc aat 211Gly Thr Glu Leu Ala Glu Ala Gly Asp Ile Phe Lys Ala Phe Ile Asn

25 30 35tct ggt ggc acg ctt atc gac gtc tcc ccc aac tac acc acc ggc gtc 259Ser Gly Gly Thr Leu Ile Asp Val Ser Pro Asn Tyr Thr Thr Gly Val

40 45 50gcg gaa gaa atg ctc ggc acg atg ttg gat gcg gaa gtc tct cgt tcg 307Ala Glu Glu Met Leu Gly Thr Met Leu Asp Ala Glu Val Ser Arg Ser

55 60 65gct gtc gtc att tcc tcc agc gca ggt gtc aac ccc gct ctg ccg ctc 355Ala Val Val Ile Ser Ser Ser Ala Gly Val Asn Pro Ala Leu Pro Leu 70 75 80 85ggc cga cgt gtg gat tgc tcc cgc cgc aat ttg att gcc caa tta gat 403Gly Arg Arg Val Asp Cys Ser Arg Arg Asn Leu Ile Ala Gln Leu Asp

90 95 100gtc acc ctg cgg gca tta aac act gac tat ttg gat ttg tgg tct gtg 451Val Thr Leu Arg Ala Leu Asn Thr Asp Tyr Leu Asp Leu Trp Ser Val

105 110 115ggc tat tgg gat gag ggc acc cca ccg cat gag gtg gcc gat act ttg 499Gly Tyr Trp Asp Glu Gly Thr Pro Pro His Glu Val Ala Asp Thr Leu

120 125 130gat tac gcc gtg cgc acc ggc cga gtc cga tat gcc ggt gtc cga gga 547Asp Tyr Ala Val Arg Thr Gly Arg Val Arg Tyr Ala Gly Val Arg Gly

135 140 145tat tcc ggt tgg cag tta gcg gtc acc cac gct gca tcc aat cat gca 595Tyr Ser Gly Trp Gln Leu Ala Val Thr His Ala Ala Ser Asn His Ala150 155 160 165gcg gcc tcc gcc cgc ccc gtg gtc gtt gca caa aat gaa tac agc ctg 643Ala Ala Ser Ala Arg Pro Val Val Val Ala Gln Asn Glu Tyr Ser Leu

170 175 180ctg gaa cgc cgc gca gaa caa gaa ctc ctc cct gcc acc caa cac cta 691Leu Glu Arg Arg Ala Glu Gln Glu Leu Leu Pro Ala Thr Gln His Leu

185 190 195ggt gtc gga ttc ttt gct ggc gct ccg ctg ggg caa ggc gtg ctg act 739Gly Val Gly Phe Phe Ala Gly Ala Pro Leu Gly Gln Gly Val Leu Thr

200 205 210gct aaa tac cgc tcc gaa att ccc cat gat tcc aga gct gca tcc aca 787Ala Lys Tyr Arg Ser Glu Ile Pro His Asp Ser Arg Ala Ala Ser Thr

215 220 225gga cgc gac gca gaa gtc caa agc tac cta gat aat cga ggc cgc atc 835Gly Arg Asp Ala Glu Val Gln Ser Tyr Leu Asp Asn Arg Gly Arg Ile230 235 240245att gtc gat gct ctt gat act gca gcc aaa gga tta ggc att agc ccc 883Ile Val Asp Ala Leu Asp Thr Ala Ala Lys Gly Leu Gly Ile Ser Pro

250 255 260gct gtc aca gcc acc acc tgg gtg cgt gat cgt ccc gga gtg aca gct 931Ala Val Thr Ala Thr Thr Trp Val Arg Asp Arg Pro Gly Val Thr Ala

265 270 275gtc atc gtg ggc gct cgc aca cat gaa cag ctg tca cat ctt ctc aag 979Val Ile Val Gly Ala Arg Thr His Glu Gln Leu Ser His Leu Leu Lys

280 285 290gcg gaa tcg gtg act ttg cca aca cca atc aca caa gcc ctt gat gat 1027Ala Glu Ser Val Thr Leu Pro Thr Pro Ile Thr Gln Ala Leu Asp Asp

295300305 gtc tcc ctg tgacttggtc caattacatt cac 1059Val Ser Leu310<210>868<211>312<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>868Met Val Gly Ser Ser Gly Leu Arg Val Ser Arg Leu Gly Leu Gly Thr 151015 Ser Thr Trp Gly Ser Gly Thr Glu Leu Ala Glu Ala Gly Asp Ile Phe

20 25 30Lys Ala Phe Ile Asn Ser Gly Gly Thr Leu Ile Asp Val Ser Pro Asn

35 40 45Tyr Thr Thr Gly Val Ala Glu Glu Met Leu Gly Thr Met Leu Asp Ala

50 55 60Glu Val Ser Arg Ser Ala Val Val Ile Ser Ser Ser Ala Gly Val Asn 65 70 75 80Pro Ala Leu Pro Leu Gly Arg Arg Val Asp Cys Ser Arg Arg Asn Leu

85 90 95Ile Ala Gln Leu Asp Val Thr Leu Arg Ala Leu Asn Thr Asp Tyr Leu

100 105 110Asp Leu Trp Ser Val Gly Tyr Trp Asp Glu Gly Thr Pro Pro His Glu

115 120 125Val Ala Asp Thr Leu Asp Tyr Ala Val Arg Thr Gly Arg Val Arg Tyr

130 135 140Ala Gly Val Arg Gly Tyr Ser Gly Trp Gln Leu Ala Val Thr His Ala145 150 155 160Ala Ser Asn His Ala Ala Ala Ser Ala Arg Pro Val Val Val Ala Gln

165 170 175Asn Glu Tyr Ser Leu Leu Glu Arg Arg Ala Glu Gln Glu Leu Leu Pro

180 185 190Ala Thr Gln His Leu Gly Val Gly Phe Phe Ala Gly Ala Pro Leu Gly

195 200 205Gln Gly Val Leu Thr Ala Lys Tyr Arg Ser Glu Ile Pro His Asp Ser

210 215 220Arg Ala Ala Ser Thr Gly Arg Asp Ala Glu Val Gln Ser Tyr Leu Asp225 230 235 240Asn Arg Gly Arg Ile Ile Val Asp Ala Leu Asp Thr Ala Ala Lys Gly

245 250 255Leu Gly Ile Ser Pro Ala Val Thr Ala Thr Thr Trp Val Arg Asp Arg

260 265 270Pro Gly Val Thr Ala Val Ile Val Gly Ala Arg Thr His Glu Gln Leu

275 280 285Ser His Leu Leu Lys Ala Glu Ser Val Thr Leu Pro Thr Pro Ile Thr

290295300 Gln Ala Leu Asp Asp Val Ser Leu 305310<210>869<211>621<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220>CDS<222>(101) }, (598)<223>RXS03074<400>869tttgtgggca atctggtttt ttcgtaattg tgtgggatga atctcttaaa aattcacatt 60tagcaggaca agcatactgt tttagttcta tgctgtgggc atgact caa agt gct 115

Met Thr Gln Ser Ala

1 5cca gaa ttc att gcc acc gca gac ctc gta gac atc atc ggc gac aac 163Pro Glu Phe Ile Ala Thr Ala Asp Leu Val Asp Ile Ile Gly Asp Asn

10 15 20gcg caa tca tgc gac act cag ttt caa aac ctt gga ggt gcc aca gaa 211Ala Gln Ser Cys Asp Thr Gln Phe Gln Asn Leu Gly Gly Ala Thr Glu

25 30 35ttc cac gga ata ata acc acc gtg aaa tgc ttc caa gac aac gcc ctc 259Phe His Gly Ile Ile Thr Thr Val Lys Cys Phe Gln Asp Asn Ala Leu

40 45 50ctg aaa tcc atc ctg agc gag gat aat cct ggg gga gtg ctg gtt atc 307Leu Lys Ser Ile Leu Ser Glu Asp Asn Pro Gly Gly Val Leu Val Ile

55 60 65gat ggc gac gca tcc gtg cac acc gcg cta gtt ggc gac atc att gca 355Asp Gly Asp Ala Ser Val His Thr Ala Leu Val Gly Asp Ile Ile Ala 70 75 80 85gga ctt gga aaa gat cat ggt tgg tcc gga gta att gtc aac gga gca 403Gly Leu Gly Lys Asp His Gly Trp Ser Gly Val Ile Val Asn Gly Ala

90 95 100att cga gac tcc gca gtc atc ggc acc atg acc ttt ggt tgt aaa gcc 451Ile Arg Asp Ser Ala Val Ile Gly Thr Met Thr Phe Gly Cys Lys Ala

105 110 115ctt gga acc aac ccg cgg aaa tcc act aaa act ggt tcc ggc gaa cga 499Leu Gly Thr Asn Pro Arg Lys Ser Thr Lys Thr Gly Ser Gly Glu Arg

120 125 130gac gta gtg gta tcg att ggt ggc att gac ttc att cct ggt cat tac 547Asp Val Val Val Ser Ile Gly Gly Ile Asp Phe Ile Pro Gly His Tyr

135140145 gtc tac gcg gac tct gac gga att atc gtc acc gag gcg cca att aag 595Val Tyr Ala Asp Ser Asp Gly Ile Ile Val Thr Glu Ala Pro Ile Lys 150155160165 cag taatttgttt tgacgacgca gta 621Gln<210>870<211>166<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>870Met Thr Gln Ser Ala Pro Glu Phe Ile Ala Thr Ala Asp Leu Val Asp 151015 Ile Ile Gly Asp Asn Ala Gln Ser Cys Asp Thr Gln Phe Gln Asn Leu

20 25 30Gly Gly Ala Thr Glu Phe His Gly Ile Ile Thr Thr Val Lys Cys Phe

35 40 45Gln Asp Asn Ala Leu Leu Lys Ser Ile Leu Ser Glu Asp Asn Pro Gly

50 55 60Gly Val Leu Val Ile Asp Gly Asp Ala Ser Val His Thr Ala Leu Val 65 70 75 80Gly Asp Ile Ile Ala Gly Leu Gly Lys Asp His Gly Trp Ser Gly Val

85 90 95Ile Val Asn Gly Ala Ile Arg Asp Ser Ala Val Ile Gly Thr Met Thr

100 105 110Phe Gly Cys Lys Ala Leu Gly Thr Asn Pro Arg Lys Ser Thr Lys Thr

115 120 125Gly Ser Gly Glu Arg Asp Val Val Val Ser Ile Gly Gly Ile Asp Phe

130 135 140Ile Pro Gly His Tyr Val Tyr Ala Asp Ser Asp Gly Ile Ile Val Thr145 150 155 160Glu Ala Pro Ile Lys Gln

165<210>871<211>621<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (598)<223>FRXA02906<400>871tttgtgggca atctggtttt ttcgtaattg tgtgggatga atctcttaaa aattcacatt 60tagcaggaca agcatactgt tttagttcta tgctgtgggc atg act caa agt gct 115

Met Thr Gln Ser Ala

1 5cca gaa ttc att gcc acc gca gac ctc gta gac atc atc ggc gac aac 163Pro Glu Phe Ile Ala Thr Ala Asp Leu Val Asp Ile Ile Gly Asp Asn

10 15 20gcg caa tca tgc gac act cag ttt caa aac ctt gga ggt gcc aca gaa 211Ala Gln Ser Cys Asp Thr Gln Phe Gln Asn Leu Gly Gly Ala Thr Glu

25 30 35ttc cac gga ata ata acc acc gtg aaa tgc ttc caa gac aac gcc ctc 259Phe His Gly Ile Ile Thr Thr Val Lys Cys Phe Gln Asp Asn Ala Leu

40 45 50ctg aaa tcc atc ctg agc gag gat aat cct ggg gga gtg ctg gtt atc 307Leu Lys Ser Ile Leu Ser Glu Asp Asn Pro Gly Gly Val Leu Val Ile

55 60 65gat ggc gac gca tcc gtg cac acc gcg cta gtt ggc gac atc att gca 355Asp Gly Asp Ala Ser Val His Thr Ala Leu Val Gly Asp Ile Ile Ala 70 75 80 85gga ctt gga aaa gat cat ggt tgg tcc gga gta att gtc aac gga gca 403Gly Leu Gly Lys Asp His Gly Trp Ser Gly Val Ile Val Asn Gly Ala

90 95 100att cga gac tcc gca gtc atc ggc acc atg acc ttt ggt tgt aaa gcc 451Ile Arg Asp Ser Ala Val Ile Gly Thr Met Thr Phe Gly Cys Lys Ala

105 110 115ctt gga acc aac ccg cgg aaa tcc act aaa act ggt tcc ggc gaa cga 499Leu Gly Thr Asn Pro Arg Lys Ser Thr Lys Thr Gly Ser Gly Glu Arg

120 125 130gac gta gtg gta tcg att ggt ggc att gac ttc att cct ggt cat tac 547Asp Val Val Val Ser Ile Gly Gly Ile Asp Phe Ile Pro Gly His Tyr

135140145 gtc tac gcg gac tct gac gga att atc gtc acc gag gcg cca att aag 595Val Tyr Ala Asp Ser Asp Gly Ile Ile Val Thr Glu Ala Pro Ile Lys 150155160165 cag taatttgttt tgacgacgca gta 621Gln<210>872<211>166<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>872Met Thr Gln Ser Ala Pro Glu Phe Ile Ala Thr Ala Asp Leu Val Asp 151015 Ile Ile Gly Asp Asn Ala Gln Ser Cys Asp Thr Gln Phe Gln Asn Leu

20 25 30Gly Gly Ala Thr Glu Phe His Gly Ile Ile Thr Thr Val Lys Cys Phe

35 40 45Gln Asp Asn Ala Leu Leu Lys Ser Ile Leu Ser Glu Asp Asn Pro Gly

50 55 60Gly Val Leu Val Ile Asp Gly Asp Ala Ser Val His Thr Ala Leu Val 65 70 75 80Gly Asp Ile Ile Ala Gly Leu Gly Lys Asp His Gly Trp Ser Gly Val

85 90 95Ile Val Asn Gly Ala Ile Arg Asp Ser Ala Val Ile Gly Thr Met Thr

100 105 110Phe Gly Cys Lys Ala Leu Gly Thr Asn Pro Arg Lys Ser Thr Lys Thr

115 120 125Gly Ser Gly Glu Arg Asp Val Val Val Ser Ile Gly Gly Ile Asp Phe

130 135 140Ile Pro Gly His Tyr Val Tyr Ala Asp Ser Asp Gly Ile Ile Val Thr145 150 155 160Glu Ala Pro Ile Lys Gln

165<210>873<211>1752<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1729)<223>RXA02315<400>873cgtttggaaa cgcttgctgc cagcaaagat aggcgtgatt ggtggtttga gcgcgtgcgt 60gaatcgtatc cgtacctgga gacgatctag actgttgtgc atg tcc agc acg cca 115

Met Ser Ser Thr Pro

1 5gct caa gat ctt gcc cgc gcc gtt att gat tcc ctc gca cca cac gtc 163Ala Gln Asp Leu Ala Arg Ala Val Ile Asp Ser Leu Ala Pro His Val

10 15 20act gac gtg gtg tta tgc cca gga tcc agg aac tca ccg ttg tcg ctt 211Thr Asp Val Val Leu Cys Pro Gly Ser Arg Asn Ser Pro Leu Ser Leu

25 30 35gag ttg ctg gcg cgg cag gat ctg cgt gtc cat gtg cgt atc gac gag 259Glu Leu Leu Ala Arg Gln Asp Leu Arg Val His Val Arg Ile Asp Glu

40 45 50cgc agc gcc tca ttt ttg gcg ctg tcc cta gcg cgt acc cag gcc cgg 307Arg Ser Ala Ser Phe Leu Ala Leu Ser Leu Ala Arg Thr Gln Ala Arg

55 60 65ccg gtg gct gtg gtg atg acc tcc ggc acg gct gta gct aac tgc ctg 355Pro Val Ala Val Val Met Thr Ser Gly Thr Ala Val Ala Asn Cys Leu 70 75 80 85cct gct gtt gct gaa gct gcg cat gcc cat atc ccg ttg att gtg ctc 403Pro Ala Val Ala Glu Ala Ala His Ala His Ile Pro Leu Ile Val Leu

90 95 100tct gct gac cgt cct gca cat ttg gtg gga acg ggg gcg agc caa acg 451Ser Ala Asp Arg Pro Ala His Leu Val Gly Thr Gly Ala Ser Gln Thr

105 110115att aac cag acc ggt att ttt ggt gat ctt gca ccg acg gtc ggt atc 499Ile Asn Gln Thr Gly Ile Phe Gly Asp Leu Ala Pro Thr Val Gly Ile

120 125 130act gag ctg gat cag gta gcg cag att gct gaa agc ctt gct cag ggg 547Thr Glu Leu Asp Gln Val Ala Gln Ile Ala Glu Ser Leu Ala Gln Gly

135 140 145gct tcc cag att ccg cgt cat ttc aat ctt gca ctt gat gtt cct ttg 595Ala Ser Gln Ile Pro Arg His Phe Asn Leu Ala Leu Asp Val Pro Leu150 155 160 165gtt gct cct gaa ctg cca gag ctt cat ggt gag gca gtt gga gca tca 643Val Ala Pro Glu Leu Pro Glu Leu His Gly Glu Ala Val Gly Ala Ser

170 175 180tgg acg cat cgc tgg atc aac cac ggt gag gtg acc gtg gac ctg ggg 691Trp Thr His Arg Trp Ile Asn His Gly Glu Val Thr Val Asp Leu Gly

185 190 195gag cac acc ctc gtg att gcc ggt gat gaa gca tgg gaa gtg gaa ggg 739Glu His Thr Leu Val Ile Ala Gly Asp Glu Ala Trp Glu Val Glu Gly

200 205 210ctg gaa gat gtg ccc acc atc gct gaa cct act gca cca aag cct tat 787Leu Glu Asp Val Pro Thr Ile Ala Glu Pro Thr Ala Pro Lys Pro Tyr

215 220 225aat ccg gtg cac cca ctg gct gct gaa atc ttg ctg aag gag cag gtc 835Asn Pro Val His Pro Leu Ala Ala Glu Ile Leu Leu Lys Glu Gln Val230 235 240 245tcc gcg gaa ggc tat gtg gta aac acc agg cct gat cat gtg atc gtg 883Ser Ala Glu Gly Tyr Val Val Asn Thr Arg Pro Asp His Val Ile Val

250 255 260gtg gga cac ccc acg ctg cac cgc gga gtg ttg aag ttg atg tca gat 931Val Gly His Pro Thr Leu His Arg Gly Val Leu Lys Leu Met Ser Asp

265 270 275cct ggc att aaa tta act gtg ctt tca cgc acc gat atc atc act gat 979Pro Gly Ile Lys Leu Thr Val Leu Ser Arg Thr Asp Ile Ile Thr Asp

280 285 290ccc ggc cgc cat gcc gat cag gtg ggc agc aca gtg aaa gtc acc ggc 1027Pro Gly Arg His Ala Asp Gln Val Gly Ser Thr Val Lys Val Thr Gly

295 300 305acc cag gaa aag cag tgg cta aag atc tgt tcg gca gca tca gaa ctt 1075Thr Gln Glu Lys Gln Trp Leu Lys Ile Cys Ser Ala Ala Ser Glu Leu310 315 320 325gcg gcc gat ggt gtg cgt gac gtc ctg gac aac caa gaa ttc ggt ttc 1123Ala Ala Asp Gly Val Arg Asp Val Leu Asp Asn Gln Glu Phe Gly Phe

330 335 340acc ggc ctc cat gtt gcc gca gcc gtg gcg gat acc tta ggc acc ggc 1171Thr Gly Leu His Val Ala Ala Ala Val Ala Asp Thr Leu Gly Thr Gly

345 350 355gat act ctc ttt gct gca gca tcc aac tca atc cgt gac ctc tcc ctg 1219Asp Thr Leu Phe Ala Ala Ala Ser Asn Ser Ile Arg Asp Leu Ser Leu

360 365 370gtg ggt atg cct ttt gat ggc gtg gat acc ttc tcc cca cga ggt gtc 1267Val Gly Met Pro Phe Asp Gly Val Asp Thr Phe Ser Pro Arg Gly Val

375 380 385gca ggc att gat ggt tct gtt gct caa gca atc ggc act tca ctt gct 1315Ala Gly Ile Asp Gly Ser Val Ala Gln Ala Ile Gly Thr Ser Leu Ala390 395 400 405gtg cag tcc cgc cac ccc gat gaa atc cgc gcg cca cgc act gtg gcc 1363Val Gln Ser Arg His Pro Asp Glu Ile Arg Ala Pro Arg Thr Val Ala

410 415420ctt ctg ggc gat ctg tcg ttc ctt cac gat att ggc gga ctg ctc atc 1411Leu Leu Gly Asp Leu Ser Phe Leu His Asp Ile Gly Gly Leu Leu Ile

425 430 435ggc cct gat gaa cca cgc cca gaa aac ctc acc atc gtg gtc tcc aac 1459Gly Pro Asp Glu Pro Arg Pro Glu Asn Leu Thr Ile Val Val Ser Asn

440 445 450gac aac ggt ggc gga atc ttc gaa ctc cta gaa acc ggc gca gat ggt 1507Asp Asn Gly Gly Gly Ile Phe Glu Leu Leu Glu Thr Gly Ala Asp Gly

455 460 465ctc cgc ccc aac ttc gag cgt gct ttc ggt acc cca cac gac gcg tcc 1555Leu Arg Pro Asn Phe Glu Arg Ala Phe Gly Thr Pro His Asp Ala Ser470 475 480 485atc gcg gat ctc tgc gca ggc tac ggc att gaa cac caa gtg gta gac 1603Ile Ala Asp Leu Cys Ala Gly Tyr Gly Ile Glu His Gln Val Val Asp

490 495 500aac ctc caa gac ctc atc atc gcg cta gtt gat acc acc gaa gta tcc 1651Asn Leu Gln Asp Leu Ile Ile Ala Leu Val Asp Thr Thr Glu Val Ser

505 510 515gga ttc acc att att gaa gct tcg acc gtc cga gat acc cgc cgt gca 1699Gly Phe Thr Ile Ile Glu Ala Ser Thr Val Arg Asp Thr Arg Arg Ala

520 525 530caa cag caa gct ctc atg gac acg gtg cac taaatggagt ggtaccaagt 1749Gln Gln Gln Ala Leu Met Asp Thr Val His

535540 gcg 1752<210>874<211>543<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>874Met Ser Ser Thr Pro Ala Gln Asp Leu Ala Arg Ala Val Ile Asp Ser 151015 Leu Ala Pro His Val Thr Asp Val Val Leu Cys Pro Gly Ser Arg Asn

20 2530Ser Pro Leu Ser Leu Glu Leu Leu Ala Arg Gln Asp Leu Arg Val His

35 40 45Val Arg Ile Asp Glu Arg Ser Ala Ser Phe Leu Ala Leu Ser Leu Ala

50 55 60Arg Thr Gln Ala Arg Pro Val Ala Val Val Met Thr Ser Gly Thr Ala 65 70 75 80Val Ala Asn Cys Leu Pro Ala Val Ala Glu Ala Ala His Ala His Ile

85 90 95Pro Leu Ile Val Leu Ser Ala Asp Arg Pro Ala His Leu Val Gly Thr

100 105 110Gly Ala Ser Gln Thr Ile Asn Gln Thr Gly Ile Phe Gly Asp Leu Ala

115 120 125Pro Thr Val Gly Ile Thr Glu Leu Asp Gln Val Ala Gln Ile Ala Glu

130 135 140Ser Leu Ala Gln Gly Ala Ser Gln Ile Pro Arg His Phe Asn Leu Ala145 150 155 160Leu Asp Val Pro Leu Val Ala Pro Glu Leu Pro Glu Leu His Gly Glu

165 170 175Ala Val Gly Ala Ser Trp Thr His Arg Trp Ile Asn His Gly Glu Val

180 185 190Thr Val Asp Leu Gly Glu His Thr Leu Val Ile Ala Gly Asp Glu Ala

195 200 205Trp Glu Val Glu Gly Leu Glu Asp Val Pro Thr Ile Ala Glu Pro Thr

210 215 220Ala Pro Lys Pro Tyr Asn Pro Val His Pro Leu Ala Ala Glu Ile Leu225 230 235 240Leu Lys Glu Gln Val Ser Ala Glu Gly Tyr Val Val Asn Thr Arg Pro

245 250255Asp His Val Ile Val Val Gly His Pro Thr Leu His Arg Gly Val Leu

260 265 270Lys Leu Met Ser Asp Pro Gly Ile Lys Leu Thr Val Leu Ser Arg Thr

275 280 285Asp Ile Ile Thr Asp Pro Gly Arg His Ala Asp Gln Val Gly Ser Thr

290 295 300Val Lys Val Thr Gly Thr Gln Glu Lys Gln Trp Leu Lys Ile Cys Ser305 310 315 320Ala Ala Ser Glu Leu Ala Ala Asp Gly Val Arg Asp Val Leu Asp Asn

325 330 335Gln Glu Phe Gly Phe Thr Gly Leu His Val Ala Ala Ala Val Ala Asp

340 345 350Thr Leu Gly Thr Gly Asp Thr Leu Phe Ala Ala Ala Ser Asn Ser Ile

355 360 365Arg Asp Leu Ser Leu Val Gly Met Pro Phe Asp Gly Val Asp Thr Phe

370 375 380Ser Pro Arg Gly Val Ala Gly Ile Asp Gly Ser Val Ala Gln Ala Ile385 390 395 400Gly Thr Ser Leu Ala Val Gln Ser Arg His Pro Asp Glu Ile Arg Ala

405 410 415Pro Arg Thr Val Ala Leu Leu Gly Asp Leu Ser Phe Leu His Asp Ile

420 425 430Gly Gly Leu Leu Ile Gly Pro Asp Glu Pro Arg Pro Glu Asn Leu Thr

435 440 445Ile Val Val Ser Asn Asp Asn Gly Gly Gly Ile Phe Glu Leu Leu Glu

450 455 460Thr Gly Ala Asp Gly Leu Arg Pro Asn Phe Glu Arg Ala Phe Gly Thr465 470475 480Pro His Asp Ala Ser Ile Ala Asp Leu Cys Ala Gly Tyr Gly Ile Glu

485 490 495His Gln Val Val Asp Asn Leu Gln Asp Leu Ile Ile Ala Leu Val Asp

500 505 510Thr Thr Glu Val Ser Gly Phe Thr Ile Ile Glu Ala Ser Thr Val Arg

515 520 525Asp Thr Arg Arg Ala Gln Gln Gln Ala Leu Met Asp Thr Val His

530535540<210>875<211>1080<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1057)<223>RXA02319<400>875atgtgggtga gataaccgac cgtgatgtcg ccctagcaaa agtcatcgac gcccacgcca 60agaccttggc catttcggca gaggcttaag gttaaagatt atg agc aac tac agc 115

Met Ser Asn Tyr Ser

1 5acc gac aac cct ttt gat ccc acc caa tgg gcc acc gtt cca ggt ttt 163Thr Asp Asn Pro Phe Asp Pro Thr Gln Trp Ala Thr Val Pro Gly Phe

10 15 20gaa gaa ttc acc gac atc acc tac cac cgc cac gtg ggc acc acc cgc 211Glu Glu Phe Thr Asp Ile Thr Tyr His Arg His Val Gly Thr Thr Arg

25 30 35gcc gat ggc atc gtg cgc atc gcc ttc gac cgc ccc gaa gtt cgc aat 259Ala Asp Gly Ile Val Arg Ile Ala Phe Asp Arg Pro Glu Val Arg Asn

40 45 50gct ttc cgc ccc cac acc gtc gac gag ctt tac caa gcc ctc gac cac 307Ala Phe Arg Pro His Thr Val Asp Glu Leu Tyr Gln Ala Leu Asp His

55 60 65gcg cgc cgg acc cca gatgtt gga acc atc ctg ctc acc ggc aac ggc 355Ala Arg Arg Thr Pro Asp Val Gly Thr Ile Leu Leu Thr Gly Asn Gly 70 75 80 85ccc agc gaa aaa gac ggt ggc tgg gcg ttc tgc tcc ggc ggc gac caa 403Pro Ser Glu Lys Asp Gly Gly Trp Ala Phe Cys Ser Gly Gly Asp Gln

90 95 100cgc atc cgc ggg cgc tcc ggc tac caa tac gcc acc gaa cac gcg cgc 451Arg Ile Arg Gly Arg Ser Gly Tyr Gln Tyr Ala Thr Glu His Ala Arg

105 110 115gac gat gcc acc gct gat gtc ttc acg gta gat att gcc cgc acc aaa 499Asp Asp Ala Thr Ala Asp Val Phe Thr Val Asp Ile Ala Arg Thr Lys

120 125 130gtt gaa ggc gga cgc ctc cac att ttg gaa gtc caa cgc ctc atc cgc 547Val Glu Gly Gly Arg Leu His Ile Leu Glu Val Gln Arg Leu Ile Arg

135 140 145acc atg cct aaa gtt gtc atc gca gta gtc aac ggc tgg gca gcc ggc 595Thr Met Pro Lys Val Val Ile Ala Val Val Asn Gly Trp Ala Ala Gly150 155 160 165ggt ggg cac tcc ctc cat gtc gtt tgc gac ctc acc atc gct tcc cgc 643Gly Gly His Ser Leu His Val Val Cys Asp Leu Thr Ile Ala Ser Arg

170 175 180caa gaa gca cgc ttc aag caa acc gac gct gac gtg gga tcc ttc gac 691Gln Glu Ala Arg Phe Lys Gln Thr Asp Ala Asp Val Gly Ser Phe Asp

185 190 195gct ggc tac ggc tcc gcc tac cta gcg aaa atg gtc gga cag aaa aac 739Ala Gly Tyr Gly Ser Ala Tyr Leu Ala Lys Met Val Gly Gln Lys Asn

200 205 210gcc cgc gaa atc ttc ttc ctc gga cgc acc tac gac gcc gaa cgc atg 787Ala Arg Glu Ile Phe Phe Leu Gly Arg Thr Tyr AspAla Glu Arg Met

215 220 225caa caa atg ggc gca gtc aac atc gtg gcc gac cac ggc gac cta gaa 835Gln Gln Met Gly Ala Val Asn Ile Val Ala Asp His Gly Asp Leu Glu230 235 240 245aaa gaa gcc atc caa gca gcc cgc gaa atc aac acc aaa tcc ccc acc 883Lys Glu Ala Ile Gln Ala Ala Arg Glu Ile Asn Thr Lys Ser Pro Thr

250 255 260ggg caa cgc atg ctg aaa ttc gcc ttc aat ctc acc gac gat ggc ctc 931Gly Gln Arg Met Leu Lys Phe Ala Phe Asn Leu Thr Asp Asp Gly Leu

265 270 275atg gga caa caa gtc ttc gcc ggc gaa gcc acc cgc ctg gcc tac atg 979Met Gly Gln Gln Val Phe Ala Gly Glu Ala Thr Arg Leu Ala Tyr Met

280 285 290acg gat gaa gcc gta gag ggt aag gaa gca ttc cta gaa aag cgc gaa 1027Thr Asp Glu Ala Val Glu Gly Lys Glu Ala Phe Leu Glu Lys Arg Glu

295300305 ccc aac tgg aat gaa ttc cct tac tac tac tagtgagttc atggggtcct 1077Pro Asn Trp Asn Glu Phe Pro Tyr Tyr Tyr 310315 aaa 1080<210>876<211>319<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>876Met Ser Asn Tyr Ser Thr Asp Asn Pro Phe Asp Pro Thr Gln Trp Ala 151015 Thr Val Pro Gly Phe Glu Glu Phe Thr Asp Ile Thr Tyr His Arg His

20 25 30Val Gly Thr Thr Arg Ala Asp Gly Ile Val Arg Ile Ala Phe Asp Arg

35 40 45Pro Glu Val Arg Asn Ala Phe Arg Pro His Thr Val Asp Glu Leu Tyr

50 55 60Gln Ala Leu Asp His Ala Arg Arg Thr Pro Asp Val Gly Thr Ile Leu 65 70 7580Leu Thr Gly Asn Gly Pro Ser Glu Lys Asp Gly Gly Trp Ala Phe Cys

85 90 95Ser Gly Gly Asp Gln Arg Ile Arg Gly Arg Ser Gly Tyr Gln Tyr Ala

100 105 110Thr Glu His Ala Arg Asp Asp Ala Thr Ala Asp Val Phe Thr Val Asp

115 120 125Ile Ala Arg Thr Lys Val Glu Gly Gly Arg Leu His Ile Leu Glu Val

130 135 140Gln Arg Leu Ile Arg Thr Met Pro Lys Val Val Ile Ala Val Val Asn145 150 155 160Gly Trp Ala Ala Gly Gly Gly His Ser Leu His Val Val Cys Asp Leu

165 170 175Thr Ile Ala Ser Arg Gln Glu Ala Arg Phe Lys Gln Thr Asp Ala Asp

180 185 190Val Gly Ser Phe Asp Ala Gly Tyr Gly Ser Ala Tyr Leu Ala Lys Met

195 200 205Val Gly Gln Lys Asn Ala Arg Glu Ile Phe Phe Leu Gly Arg Thr Tyr

210 215 220Asp Ala Glu Arg Met Gln Gln Met Gly Ala Val Asn Ile Val Ala Asp225 230 235 240His Gly Asp Leu Glu Lys Glu Ala Ile Gln Ala Ala Arg Glu Ile Asn

245 250 255Thr Lys Ser Pro Thr Gly Gln Arg Met Leu Lys Phe Ala Phe Asn Leu

260 265 270Thr Asp Asp Gly Leu Met Gly Gln Gln Val Phe Ala Gly Glu Ala Thr

275 280 285Arg Leu Ala Tyr Met Thr Asp Glu Ala Val Glu Gly Lys Glu Ala Phe

290295300 Leu Glu Lys Arg Glu Pro Asn Trp Asn Glu Phe Pro Tyr Tyr Tyr 305310315<210>877<211>1017<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (994)<223>RXS00393<400>877tctattcatt tcacaatagc gtttcacact cccccatagc ctgccgaacg tatttcaagc 60aattgcgcga tcgagtatgt gatggggaaa gatagaggtt atg tct cac acg gaa 115

Met Ser His Thr Glu

1 5ccc cag ccg aat tct gta act ttg tcc gat tgg att caa ggc gca cgc 163Pro Gln Pro Asn Ser Val Thr Leu Ser Asp Trp Ile Gln Gly Ala Arg

10 15 20ccg cgt acc tgg gca aat gcg ttc gcg cct gtc att gcc ggt tca ggt 211Pro Arg Thr Trp Ala Asn Ala Phe Ala Pro Val Ile Ala Gly Ser Gly

25 30 35gtc gcc gct ttt cat gat ggt ttt gtg tgg tgg aag gcc ttg ctg gcg 259Val Ala Ala Phe His Asp Gly Phe Val Trp Trp Lys Ala Leu Leu Ala

40 45 50ctt gtc gtg gcg tgg gct ttg atc atc ggt gtg aat tac gcc aat gat 307Leu Val Val Ala Trp Ala Leu Ile Ile Gly Val Asn Tyr Ala Asn Asp

55 60 65tac tct gat ggc att cgt ggc acc gat gaa gac cgc acc ggt cct ctg 355Tyr Ser Asp Gly Ile Arg Gly Thr Asp Glu Asp Arg Thr Gly Pro Leu 70 75 80 85cga ctc act ggt tct ggg ttg gct gag ccg aag aaa gtg aaa gct gcg 403Arg Leu Thr Gly Ser Gly Leu Ala Glu Pro Lys Lys Val Lys Ala Ala

90 95 100gcg ttt att tct ttc ggt atc gca ggt gtc gcc ggc acc gcg ctg agc 451Ala Phe Ile Ser Phe Gly Ile Ala Gly Val Ala Gly Thr Ala Leu Ser

105 110 115ctg ttg agc gcg tgg tgg ctg atc ctc atc ggc atc ctg tgt gtg ctg 499Leu Leu Ser Ala Trp Trp Leu Ile Leu Ile Gly Ile Leu Cys Val Leu

120 125 130ggc gcg tgg ttc tac acc ggc ggt aaa aat cct tat ggt tac cgc ggg 547Gly Ala Trp Phe Tyr Thr Gly Gly Lys Asn Pro Tyr Gly Tyr Arg Gly

135 140 145ctc ggc gag att gct gtg ttc atc ttc ttc ggc ctc gtc gcg gtc atg 595Leu Gly Glu Ile Ala Val Phe Ile Phe Phe Gly Leu Val Ala Val Met150 155 160 165gga acg cag ttc acc caa acc ggt tcc gtc agc tgg gcc ggt ttg gcc 643Gly Thr Gln Phe Thr Gln Thr Gly Ser Val Ser Trp Ala Gly Leu Ala

170 175 180gcc gca gtt ggc gtg ggg tcg atg tct gct ggc gtg aac ttg gcc aac 691Ala Ala Val Gly Val Gly Ser Met Ser Ala Gly Val Asn Leu Ala Asn

185 190 195aat att cgc gat att cca acc gat agc aag acc gga aaa att acc ctc 739Asn Ile Arg Asp Ile Pro Thr Asp Ser Lys Thr Gly Lys Ile Thr Leu

200 205 210gcg gtc cgc ctg ggc gat gcg ggt gct cgt aag ctg ttc ctc gcg ctg 787Ala Val Arg Leu Gly Asp Ala Gly Ala Arg Lys Leu Phe Leu Ala Leu

215 220 225att tcc acg ccg ttc atc atg tcc atc tgc ctg gcg ttt gtc gcc tgg 835Ile Ser Thr Pro Phe Ile Met Ser Ile Cys Leu Ala Phe Val Ala Trp230 235 240 245cca gcg ctg atc gcg atc atc gtt ttc ccg ctg gca ctg aaa gcc gca 883Pro Ala Leu Ile Ala Ile Ile Val Phe Pro Leu Ala Leu Lys Ala Ala

250 255 260ggg ccg atc cgc aac aac gcc acc ggc aag gat ctc atc ccc gtc atc 931Gly Pro Ile Arg Asn Asn Ala Thr Gly Lys Asp Leu Ile Pro Val Ile

265 270 275ggc tca aca ggg cgc gcc atg gcg ttg tgg gcc gtg ctc acg ggc ctg 979Gly Ser Thr Gly Arg Ala Met Ala Leu Trp Ala Val Leu Thr Gly Leu

280 285 290gca tta gcg ttt agc taaaacgctt ttcgacgctc ccc 1017Ala Leu Ala Phe Ser

295<210>878<211>298<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>878Met Ser His Thr Glu Pro Gln Pro Asn Ser Val Thr Leu Ser Asp Trp 151015 Ile Gln Gly Ala Arg Pro Arg Thr Trp Ala Asn Ala Phe Ala Pro Val

20 25 30Ile Ala Gly Ser Gly Val Ala Ala Phe His Asp Gly Phe Val Trp Trp

35 40 45Lys Ala Leu Leu Ala Leu Val Val Ala Trp Ala Leu Ile Ile Gly Val

50 55 60Asn Tyr Ala Asn Asp Tyr Ser Asp Gly Ile Arg Gly Thr Asp Glu Asp 65 70 75 80Arg Thr Gly Pro Leu Arg Leu Thr Gly Ser Gly Leu Ala Glu Pro Lys

85 90 95Lys Val Lys Ala Ala Ala Phe Ile Ser Phe Gly Ile Ala Gly Val Ala

100 105 110Gly Thr Ala Leu Ser Leu Leu Ser Ala Trp Trp Leu Ile Leu Ile Gly

115 120 125Ile Leu Cys Val Leu Gly Ala Trp Phe Tyr Thr Gly Gly Lys Asn Pro

130 135 140Tyr Gly Tyr Arg Gly Leu Gly Glu Ile Ala Val Phe Ile Phe Phe Gly145 150 155 160Leu Val Ala Val Met Gly Thr Gln Phe Thr Gln Thr Gly Ser Val Ser

165 170 175Trp Ala Gly Leu Ala Ala Ala Val Gly Val Gly Ser Met Ser Ala Gly

180 185 190Val Asn Leu Ala Asn Asn Ile Arg Asp Ile Pro Thr Asp Ser Lys Thr

195 200 205Gly Lys Ile Thr Leu Ala Val Arg Leu Gly Asp Ala Gly Ala Arg Lys

210 215 220Leu Phe Leu Ala Leu Ile Ser Thr Pro Phe Ile Met Ser Ile Cys Leu225 230 235 240Ala Phe Val Ala Trp Pro Ala Leu Ile Ala Ile Ile Val Phe Pro Leu

245 250 255Ala Leu Lys Ala Ala Gly Pro Ile Arg Asn Asn Ala Thr Gly Lys Asp

260 265 270Leu Ile Pro Val Ile Gly Ser Thr Gly Arg Ala Met Ala Leu Trp Ala

275 280 285Val Leu Thr Gly Leu Ala Leu Ala Phe Ser

290295<210>879<211>1005<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (982)<223>FRXA00393<400>879tctattcatt tcacaatagc gtttcacact cccccatagc ctgccgaacg tatttcaagc 60aattgcgcga tcgagtatgt gatggggaaa gatagaggtt atg tct cac acg gaa 115

Met Ser His Thr Glu

1 5ccc cag ccg aat tct gta act ttg tcc gat tgg att caa ggc gca cgc 163Pro Gln Pro Asn Ser Val Thr Leu Ser Asp Trp Ile Gln Gly Ala Arg

10 15 20ccg cgt acc tgg gca aat gcg ttc gcg cct gtc att gcc ggt tca ggt 211Pro Arg Thr Trp Ala Asn Ala Phe Ala Pro Val Ile Ala Gly Ser Gly

25 30 35gtc gcc gct ttt cat gat ggt ttt gtg tgg tgg aag gcc ttg ctg gcg 259Val Ala Ala Phe His Asp Gly Phe Val Trp Trp Lys Ala Leu Leu Ala

40 45 50ctt gtc gtg gcg tgg gct ttg atc atc ggt gtg aat tac gcc aat gat 307Leu Val Val Ala Trp Ala Leu Ile Ile Gly Val Asn Tyr Ala Asn Asp

55 60 65tac tct gat ggc att cgt ggc acc gat gaa gac cgc acc ggt cct ctg 355Tyr Ser Asp Gly Ile Arg Gly Thr Asp Glu Asp Arg Thr Gly Pro Leu 70 75 80 85cga ctc act ggt tct ggg ttg gct gag ccg aag aaa gtg aaa gct gcg 403Arg Leu Thr Gly Ser Gly Leu Ala Glu Pro Lys Lys Val Lys Ala Ala

90 95 100gcg ttt att tct ttc ggt atc gca ggt gtc gcc ggc acc gcg ctg agc 451Ala Phe Ile Ser Phe Gly Ile Ala Gly Val Ala Gly Thr Ala Leu Ser

105 110 115ctg ttg agc gcg tgg tgg ctg atc ctc atc ggc atc ctg tgt gtg ctg 499Leu Leu Ser Ala Trp Trp Leu Ile Leu Ile Gly Ile Leu Cys Val Leu

120 125 130ggc gcg tgg ttc tac acc ggc ggt aaa aat cct tat ggt tac cgc ggg 547Gly Ala Trp Phe Tyr Thr Gly Gly Lys Asn Pro Tyr Gly Tyr Arg Gly

135 140 145ctc ggc gag att gct gtg ttc atc ttc ttc ggc ctc gtc gcg gtc atg 595Leu Gly Glu Ile Ala Val Phe Ile Phe Phe Gly Leu Val Ala Val Met150 155 160 165gga acg cag ttc acc caa acc ggt tcc gtc agc tgg gcc ggt ttg gcc 643Gly Thr Gln Phe Thr Gln Thr Gly Ser Val Ser Trp Ala Gly Leu Ala

170 175 180gcc gca gtt ggc gtg ggg tcg atg tct gct ggc gtg aac ttg gcc aac 691Ala Ala Val Gly Val Gly Ser Met Ser Ala Gly Val Asn Leu Ala Asn

185 190 195aat att cgc gat att cca acc gat agc aag acc gga aaa att acc ctc 739Asn Ile Arg Asp Ile Pro Thr Asp Ser Lys Thr Gly Lys Ile Thr Leu

200 205 210gcg gtc cgc ctg ggc gat gcg ggt gct cgt aag ctg ttc ctc gcg ctg 787Ala Val Arg Leu Gly Asp Ala Gly Ala Arg Lys Leu Phe Leu Ala Leu

215 220 225att tcc acg ccg ttc atc atg tcc atc tgc ctg gcg ttt gtc gcc tgg 835Ile Ser Thr Pro Phe Ile Met Ser Ile Cys Leu Ala Phe Val Ala Trp230 235 240 245cca gcg ctg atc gcg atc atc gtt ttc ccg ctg gca ctg aaa gcc gca 883Pro Ala Leu Ile Ala Ile Ile Val Phe Pro Leu Ala Leu Lys Ala Ala

250 255 260ggg ccg atc cgc aac aac gcc acc ggc aag gat ctc atc ccg tca tcg 931Gly Pro Ile Arg Asn Asn Ala Thr Gly Lys Asp Leu Ile Pro Ser Ser

265 270 275gct caa cag ggc gcg cca tgg cgt tgt ggg ccg tgc tca cgg gcc tgg 979Ala Gln Gln Gly Ala Pro Trp Arg Cys Gly Pro Cys Ser Arg Ala Trp

280285290 cat tagcgtttag ctaaaacgct ttt 1005His<210>880<211>294<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>880Met Ser His Thr Glu Pro Gln Pro Asn Ser Val Thr Leu Ser Asp Trp 151015 Ile Gln Gly Ala Arg Pro Arg Thr Trp Ala Asn Ala Phe Ala Pro Val

20 2530Ile Ala Gly Ser Gly Val Ala Ala Phe His Asp Gly Phe Val Trp Trp

35 40 45Lys Ala Leu Leu Ala Leu Val Val Ala Trp Ala Leu Ile Ile Gly Val

50 55 60Asn Tyr Ala Asn Asp Tyr Ser Asp Gly Ile Arg Gly Thr Asp Glu Asp 65 70 75 80Arg Thr Gly Pro Leu Arg Leu Thr Gly Ser Gly Leu Ala Glu Pro Lys

85 90 95Lys Val Lys Ala Ala Ala Phe Ile Ser Phe Gly Ile Ala Gly Val Ala

100 105 110Gly Thr Ala Leu Ser Leu Leu Ser Ala Trp Trp Leu Ile Leu Ile Gly

115 120 125Ile Leu Cys Val Leu Gly Ala Trp Phe Tyr Thr Gly Gly Lys Asn Pro

130 135 140Tyr Gly Tyr Arg Gly Leu Gly Glu Ile Ala Val Phe Ile Phe Phe Gly145 150 155 160Leu Val Ala Val Met Gly Thr Gln Phe Thr Gln Thr Gly Ser Val Ser

165 170 175Trp Ala Gly Leu Ala Ala Ala Val Gly Val Gly Ser Met Ser Ala Gly

180 185 190Val Asn Leu Ala Asn Asn Ile Arg Asp Ile Pro Thr Asp Ser Lys Thr

195 200 205Gly Lys Ile Thr Leu Ala Val Arg Leu Gly Asp Ala Gly Ala Arg Lys

210 215 220Leu Phe Leu Ala Leu Ile Ser Thr Pro Phe Ile Met Ser Ile Cys Leu225 230 235 240Ala Phe Val Ala Trp Pro Ala Leu Ile Ala Ile Ile Val Phe Pro Leu

245 250255Ala Leu Lys Ala Ala Gly Pro Ile Arg Asn Asn Ala Thr Gly Lys Asp

260 265 270Leu Ile Pro Ser Ser Ala Gln Gln Gly Ala Pro Trp Arg Cys Gly Pro

275 280 285Cys Ser Arg Ala Trp His

290<210>881<211>843<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (820)<223>RXA00391<400>881atcttgtaga tcccaccgca attctgggag atctcgagga cgcaatctct ggaagaaaac 60tttcctcccc atccctgtac aagataaaac ccgtgcacag ttg ctg cgc gat tct 115

Leu Leu Arg Asp Ser

1 5caa cga gtt ggc ctc gcc atc gat cct tcg atc gct ttg gtg atg gcc 163Gln Arg Val Gly Leu Ala Ile Asp Pro Ser Ile Ala Leu Val Met Ala

10 15 20act tct ggt tct aca ggt acc ccg aag ggc gct cag ctc act ccg ttg 211Thr Ser Gly Ser Thr Gly Thr Pro Lys Gly Ala Gln Leu Thr Pro Leu

25 30 35aat ttg gtg agt tcc gcc gat gct acg cat cag ttt tta ggt ggc gaa 259Asn Leu Val Ser Ser Ala Asp Ala Thr His Gln Phe Leu Gly Gly Glu

40 45 50ggc cag tgg ttg ctt gcc atg cca gca cac cac att gca ggc atg cag 307Gly Gln Trp Leu Leu Ala Met Pro Ala His His Ile Ala Gly Met Gln

55 60 65gtg ctt ctt cga agc ctc att gct gga gtt gag cca cta gct att gat 355Val Leu Leu Arg Ser Leu Ile Ala Gly Val Glu Pro Leu Ala Ile Asp 70 75 80 85ctc agc aca ggt ttt cac att gac gct ttc gca ggc gcc gcg gca gaa 403Leu Ser Thr Gly Phe His Ile Asp Ala Phe Ala Gly Ala Ala Ala Glu

90 95 100ctg aaa aat acc ggc gac cgc gtc tat aca tcc ttg act cca atg cag 451Leu Lys Asn Thr Gly Asp Arg Val Tyr Thr Ser Leu Thr Pro Met Gln

105 110 115tta ctt aaa gca atg gac tcc ttg caa ggc att gaa gcc ctg aaa ctt 499Leu Leu Lys Ala Mel Asp Ser Leu Gln Gly Ile Glu Ala Leu Lys Leu

120 125 130ttt gat gtc att ctt gtt ggc ggt gct gca ttg tct aag cag gcc cga 547Phe Asp Val Ile Leu Val Gly Gly Ala Ala Leu Ser Lys Gln Ala Arg

135 140 145att tct gcg gag cag cta gac atc aac att gtc acc acc tac ggc tcc 595Ile Ser Ala Glu Gln Leu Asp Ile Asn Ile Val Thr Thr Tyr Gly Ser150 155 160 165tca gag act tca ggt ggc tgc gtt tat gat ggc aag ccc att ccc ggc 643Ser Glu Thr Ser Gly Gly Cys Val Tyr Asp Gly Lys Pro Ile Pro Gly

170 175 180gcg aaa gtc cgt att tcg gat gag cgc att gag ttg ggt ggc ccg atg 691Ala Lys Val Arg Ile Ser Asp Glu Arg Ile Glu Leu Gly Gly Pro Met

185 190 195att gcg cag ggc tac aga aat gca cct gaa cat ccg gat ttc gcc aac 739Ile Ala Gln Gly Tyr Arg Asn Ala Pro Glu His Pro Asp Phe Ala Asn

200 205 210gag ggt tgg ttt acc acc tct gat tca ggt gaa ctc cac gac ggg att 787Glu Gly Trp Phe Thr Thr Ser Asp Ser Gly Glu Leu His Asp Gly Ile

215220225 ctc acc gtg act ggt cgc gtg gat acc cgt cat tgattccggt ggattgaagt 840Leu Thr Val Thr Gly Arg Val Asp Thr Arg His 230235240 tgc 843<210>882<211>240<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>882Leu Leu Arg Asp Ser Gln Arg Val Gly Leu Ala Ile Asp Pro Ser Ile 151015 Ala Leu Val Met Ala Thr Ser Gly Ser Thr Gly Thr Pro Lys Gly Ala

20 25 30Gln Leu Thr Pro Leu Asn Leu Val Ser Ser Ala Asp Ala Thr His Gln

35 40 45Phe Leu Gly Gly Glu Gly Gln Trp Leu Leu Ala Met Pro Ala His His

50 55 60Ile Ala Gly Met Gln Val Leu Leu Arg Ser Leu Ile Ala Gly Val Glu 65 70 75 80Pro Leu Ala Ile Asp Leu Ser Thr Gly Phe His Ile Asp Ala Phe Ala

85 90 95Gly Ala Ala Ala Glu Leu Lys Asn Thr Gly Asp Arg Val Tyr Thr Ser

100 105 110Leu Thr Pro Met Gln Leu Leu Lys Ala Met Asp Ser Leu Gln Gly Ile

115 120 125Glu Ala Leu Lys Leu Phe Asp Val Ile Leu Val Gly Gly Ala Ala Leu

130 135 140Ser Lys Gln Ala Arg Ile Ser Ala Glu Gln Leu Asp Ile Asn Ile Val145 150 155 160Thr Thr Tyr Gly Ser Ser Glu Thr Ser Gly Gly Cys Val Tyr Asp Gly

165 170 175Lys Pro Ile Pro Gly Ala Lys Val Arg Ile Ser Asp Glu Arg Ile Glu

180 185 190Leu Gly Gly Pro Met Ile Ala Gln Gly Tyr Arg Asn Ala Pro Glu His

195 200 205Pro Asp Phe Ala Asn Glu Gly Trp Phe Thr Thr Ser Asp Ser Gly Glu

210215220 Leu His Asp Gly Ile Leu Thr Val Thr Gly Arg Val Asp Thr Arg His 225230235240<210>883<211>384<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (361)<223>RXS02908<400>883gccaacgagg gttggtttac cacctctgat tcaggtgaac tccacgacgg gattctcacc 60gtgactggtc gcgtggatac ccgtcattga ttccggtgga ttg aag ttg cac cca 115

Leu Lys Leu His Pro

1 5gag gta ctg gaa cgt gcc atc gca gat att aaa ggt gtc acc gcg gcg 163Glu Val Leu Glu Arg Ala Ile Ala Asp Ile Lys Gly Val Thr Ala Ala

10 15 20tgt gtt gtg ggt att ccc gat ccc cga tta ggc caa gca att gtg gcc 211Cys Val Val Gly Ile Pro Asp Pro Arg Leu Gly Gln Ala Ile Val Ala

25 30 35gcg tac tcc gga tcg atc agt ccg tct gaa gtt att gaa ggc ctc gac 259Ala Tyr Ser Gly Ser Ile Ser Pro Ser Glu Val Ile Glu Gly Leu Asp

40 45 50gat cta cct cgt tgg cag ctt ccc aaa cgg ctg aag cat ctg gaa tct 307Asp Leu Pro Arg Trp Gln Leu Pro Lys Arg Leu Lys His Leu Glu Ser

556065 ttg ccc agc att ggt cct gga aaa gct gat cga cgt gct atc gcg aag 355Leu Pro Ser Ile Gly Pro Gly Lys Ala Asp Arg Arg Ala Ile Ala Lys 70758085 ctg ttt tagtcttcat tcttgctggc tgc 384Leu Phe<210>884<211>87<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>884Leu Lys Leu His Pro Glu Val Leu Glu Arg Ala Ile Ala Asp Ile Lys 151015 Gly Val Thr Ala Ala Cys Val Val Gly Ile Pro Asp Pro Arg Leu Gly

20 2530Gln Ala Ile Val Ala Ala Tyr Ser Gly Ser Ile Ser Pro Ser Glu Val

35 40 45Ile Glu Gly Leu Asp Asp Leu Pro Arg Trp Gln Leu Pro Lys Arg Leu

50 55 60Lys His Leu Glu Ser Leu Pro Ser Ile Gly Pro Gly Lys Ala Asp Arg 65 70 75 80Arg Ala Ile Ala Lys Leu Phe

85<210>885<211>705<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (682)<223>RXA00997<400>885cccatctgtg gcagatcgaa tgcacccacc gcggagaagt cgtcgcacga accacactgc 60gcaccatggt gctgaacaag tagccctata ctcgggcacc atg act aca tgg aaa 115

Met Thr Thr Trp Lys

1 5gag ctc aca gat aac aac cca gcg cac tca gaa aac tac gcg cag cgc 163Glu Leu Thr Asp Asn Asn Pro Ala His Ser Glu Asn Tyr Ala Gln Arg

10 15 20tgg cga aac ctc gcc gca gca ggc aat gat att tac ggc gaa gcc cgc 211Trp Arg Asn Leu Ala Ala Ala Gly Asn Asp Ile Tyr Gly Glu Ala Arg

25 30 35ctc att gat gcc atg gca ccc agg gga gcg aaa atc ttg gat gct ggc 259Leu Ile Asp Ala Met Ala Pro Arg Gly Ala Lys Ile Leu Asp Ala Gly

40 45 50tgc ggc cag gga cgc atc ggt ggc tac ctg tcc aag caa ggc cac gat 307Cys Gly Gln Gly Arg Ile Gly Gly Tyr Leu Ser Lys Gln Gly His Asp

55 60 65gtt cta ggc aca gac ctt gat ccc atc ctg att gat tac gcc aag cag 355Val Leu Gly Thr Asp Leu Asp Pro Ile Leu Ile Asp TyrAla Lys Gln 70 75 80 85gac ttt cca gaa gct cgc tgg gtg gtg gga gat ctc tct gtt gat cag 403Asp Phe Pro Glu Ala Arg Trp Val Val Gly Asp Leu Ser Val Asp Gln

90 95 100atc tca gag act gat ttt gat ctc att gtc tcc gcc ggc aac gtc atg 451Ile Ser Glu Thr Asp Phe Asp Leu Ile Val Ser Ala Gly Asn Val Met

105 110 115ggc ttt ctc gct gag gat ggt cgc gaa cct gca cta gcc aac att cac 499Gly Phe Leu Ala Glu Asp Gly Arg Glu Pro Ala Leu Ala Asn Ile His

120 125 130cgc gca ctg ggc gcc gat ggc cgc gct gtc atc ggt ttc ggc gca gga 547Arg Ala Leu Gly Ala Asp Gly Arg Ala Val Ile Gly Phe Gly Ala Gly

135 140 145cgt gga tgg gtc ttt gga gac ttc ctc gaa gtc gca gaa cgc gtg ggc 595Arg Gly Trp Val Phe Gly Asp Phe Leu Glu Val Ala Glu Arg Val Gly150 155 160 165ctc gag ttg gaa aat gct ttt gag tct tgg gat ctt aag cct ttt gtc 643Leu Glu Leu Glu Asn Ala Phe Glu Ser Trp Asp Leu Lys Pro Phe Val

170 175 180caa ggc tct gag ttc tta gtg gcg gta ttt acc aag aag taacacctct 692Gln Gly Ser Glu Phe Leu Val Ala Val Phe Thr Lys Lys

185190 atcttgcacc tga 705<210>886<211>194<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>886Met Thr Thr Trp Lys Glu Leu Thr Asp Asn Asn Pro Ala His Ser Glu 151015 Asn Tyr Ala Gln Arg Trp Arg Asn Leu Ala Ala Ala Gly Asn Asp Ile

20 25 30Tyr Gly Glu Ala Arg Leu Ile Asp Ala Met Ala Pro Arg Gly Ala Lys

3540 45Ile Leu Asp Ala Gly Cys Gly Gln Gly Arg Ile Gly Gly Tyr Leu Ser

50 55 60Lys Gln Gly His Asp Val Leu Gly Thr Asp Leu Asp Pro Ile Leu Ile 65 70 75 80Asp Tyr Ala Lys Gln Asp Phe Pro Glu Ala Arg Trp Val Val Gly Asp

85 90 95Leu Ser Val Asp Gln Ile Ser Glu Thr Asp Phe Asp Leu Ile Val Ser

100 105 110Ala Gly Asn Val Met Gly Phe Leu Ala Glu Asp Gly Arg Glu Pro Ala

115 120 125Leu Ala Asn Ile His Arg Ala Leu Gly Ala Asp Gly Arg Ala Val Ile

130 135 140Gly Phe Gly Ala Gly Arg Gly Trp Val Phe Gly Asp Phe Leu Glu Val145 150 155 160Ala Glu Arg Val Gly Leu Glu Leu Glu Asn Ala Phe Glu Ser Trp Asp

165 170 175Leu Lys Pro Phe Val Gln Gly Ser Glu Phe Leu Val Ala Val Phe Thr

180185190 Lys Lys<210>887<211>861<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (838)<223>RXA02189<400>887aatggcaaaa atgggcacat acgatactga tgggaccaat gggaaaacct caagccacca 60attgagccag ttctctcaag caaaccgata ctggtgggat gtg gac gcg gcc gac 115

Val Asp Ala Ala Asp

1 5tat cac gaa cgc cac cct tct tat tta ggc acg gat tcc gct cac ggc 163Tyr His Glu Arg His Pro Ser Tyr Leu Gly Thr Asp Ser Ala His Gly

1015 20gag ttc tac tgg tgc ccc gag atg ctg cat gaa aaa gat gta cgt ctt 211Glu Phe Tyr Trp Cys Pro Glu Met Leu His Glu Lys Asp Val Arg Leu

25 30 35ctt ggc act ccc gca gca ctc tcc ggc aag aaa att tta gag atc ggt 259Leu Gly Thr Pro Ala Ala Leu Ser Gly Lys Lys Ile Leu Glu Ile Gly

40 45 50tgc ggc tcg gca ccg tgt gct cgg tgg ctg gcc aat gat gtt ccg aat 307Cys Gly Ser Ala Pro Cys Ala Arg Trp Leu Ala Asn Asp Val Pro Asn

55 60 65gcc ttt gtc acc gct ttc gac att tct tca caa atg ctc aaa tac gca 355Ala Phe Val Thr Ala Phe Asp Ile Ser Ser Gln Met Leu Lys Tyr Ala 70 75 80 85ggt cac gac cat aac gta cac ctc gta cag gcc gat gca atg tca ctc 403Gly His Asp His Asn Val His Leu Val Gln Ala Asp Ala Met Ser Leu

90 95 100ccc tac gcc gac agt tcc ttt gac gtg gtc ttt tcc gtt ttc ggc gcc 451Pro Tyr Ala Asp Ser Ser Phe Asp Val Val Phe Ser Val Phe Gly Ala

105 110 115atc ccc ttt gtg gag gat tcc gcc gca ctc atg aag gaa atc gcg cgc 499Ile Pro Phe Val Glu Asp Ser Ala Ala Leu Met Lys Glu Ile Ala Arg

120 125 130gtc ctc aaa ccc ggc gga cgc ctc att ttc tcc atc acc cac ccg atg 547Val Leu Lys Pro Gly Gly Arg Leu Ile Phe Ser Ile Thr His Pro Met

135 140 145cgc tgg att ttc ctc gac gat ccc ggc ccc gca ggc ctc acc gcg atc 595Arg Trp Ile Phe Leu Asp Asp Pro Gly Pro Ala Gly Leu Thr Ala Ile150 155 160 165acc agc tac ttc gac cag cgc ggc tac gtc gaa gaa gac gag gaa acc 643Thr Ser Tyr Phe Asp Gln Arg Gly Tyr Val Glu Glu Asp Glu Glu Thr

170 175 180ggt gct tta agc tat gcg gaa cag cac cgc acc atg ggc gcg cgg atc 691Gly Ala Leu Ser Tyr Ala Glu Gln His Arg Thr Met Gly Ala Arg Ile

185 190 195aat gag ctt atc gac gcc tcc ctc cac tta gat cac ctc atc gaa cca 739Asn Glu Leu Ile Asp Ala Ser Leu His Leu Asp His Leu Ile Glu Pro

200 205 210gaa tgg cca gat gag ttg gaa gaa aac tgg ggc caa tgg tca cca ctt 787Glu Trp Pro Asp Glu Leu Glu Glu Asn Trp Gly Gln Trp Ser Pro Leu

215220225 cga gga aag ctc ttc ccc ggg aca gca atc ttc ctc gcc acg tac cgc 835Arg Gly Lys Leu Phe Pro Gly Thr Ala Ile Phe Leu Ala Thr Tyr Arg 230235240245 ccc taaaaaacca acggcgctca ttt 861Pro<210>888<211>246<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>888Val Asp Ala Ala Asp Tyr His Glu Arg His Pro Ser Tyr Leu Gly Thr 151015 Asp Ser Ala His Gly Glu Phe Tyr Trp Cys Pro Glu Met Leu His Glu

20 25 30Lys Asp Val Arg Leu Leu Gly Thr Pro Ala Ala Leu Ser Gly Lys Lys

35 40 45Ile Leu Glu Ile Gly Cys Gly Ser Ala Pro Cys Ala Arg Trp Leu Ala

50 55 60Asn Asp Val Pro Asn Ala Phe Val Thr Ala Phe Asp Ile Ser Ser Gln 65 70 75 80Met Leu Lys Tyr Ala Gly His Asp His Asn Val His Leu Val Gln Ala

85 90 95Asp Ala Met Ser Leu Pro Tyr Ala Asp Ser Ser Phe Asp Val Val Phe

100 105 110Ser Val Phe Gly Ala Ile Pro Phe Val Glu Asp Ser Ala Ala Leu Met

115 120 125Lys Glu Ile Ala Arg Val Leu Lys Pro Gly Gly Arg Leu Ile Phe Ser

130 135 140Ile Thr His Pro Met Arg Trp Ile Phe Leu Asp Asp Pro Gly Pro Ala145 150 155 160Gly Leu Thr Ala Ile Thr Ser Tyr Phe Asp Gln Arg Gly Tyr Val Glu

165 170 175Glu Asp Glu Glu Thr Gly Ala Leu Ser Tyr Ala Glu Gln His Arg Thr

180 185 190Met Gly Ala Arg Ile Asn Glu Leu Ile Asp Ala Ser Leu His Leu Asp

195 200 205His Leu Ile Glu Pro Glu Trp Pro Asp Glu Leu Glu Glu Asn Trp Gly

210 215 220Gln Trp Ser Pro Leu Arg Gly Lys Leu Phe Pro Gly Thr Ala Ile Phe225 230 235 240Leu Ala Thr Tyr Arg Pro

245<210>889<211>813<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<790)<223>RXA02311<400>889cattttgggt atcggttggt tgtccatcgg tggagctaag ggcgctaagc atcgcagcca 60aataacctcc cactaaagct cctgggttag actcgaacgc gtg gct aaa gca gat 115

Val Ala Lys Ala Asp

1 5tta gac aag gac ccc ttc gac gta gcg tca atg ttc gat gac gtc gga 163Leu Asp Lys Asp Pro Phe Asp Val Ala Ser Met Phe Asp Asp Val Gly

10 15 20aag aac tac gat ctc acc aat acc gtg ctt tct ttt ggt caggac cgt 211Lys Asn Tyr Asp Leu Thr Asn Thr Val Leu Ser Phe Gly Gln Asp Arg

25 30 35gtg tgg cga aag cgc act agg cag cgc ctg gac ctc aag cca ggg gag 259Val Trp Arg Lys Arg Thr Arg Gln Arg Leu Asp Leu Lys Pro Gly Glu

40 45 50aag gtg ctt gat cta gct gca gga aca gcc gtt tcc acc gtg gag ttg 307Lys Val Leu Asp Leu Ala Ala Gly Thr Ala Val Ser Thr Val Glu Leu

55 60 65gca aaa tcc ggc gcg ttt tgt gtg gcg tgt gat ttc tcc cag ggc atg 355Ala Lys Ser Gly Ala Phe Cys Val Ala Cys Asp Phe Ser Gln Gly Met 70 75 80 85ctc gcc gca ggt aaa gac cgc gat gtg tcc aag gtt gtg ggc gat ggc 403Leu Ala Ala Gly Lys Asp Arg Asp Val Ser Lys Val Val Gly Asp Gly

90 95 100atg cag ttg ccg ttt gca gac aac agc ttt gat gct gtg acc att tct 451Met Gln Leu Pro Phe Ala Asp Asn Ser Phe Asp Ala Val Thr Ile Ser

105 110 115tat ggt ctg cgc aat att cac gat ttc cgc gct ggc ctg aaa gaa atg 499Tyr Gly Leu Arg Asn Ile His Asp Phe Arg Ala Gly Leu Lys Glu Met

120 125 130gcc cgc gtg act aaa cct ggt gga cgc ctc acc gtg gcg gag ttc tcc 547Ala Arg Val Thr Lys Pro Gly Gly Arg Leu Thr Val Ala Glu Phe Ser

135 140 145acc ccc gtg atc cct gtg ttc ggc acc gtg tac aag gag tac ctc atg 595Thr Pro Val Ile Pro Val Phe Gly Thr Val Tyr Lys Glu Tyr Leu Met150 155 160 165cgc ctg ctg ccc cag gcg gcg cgc gca gta tcg tcc aac ccg gag gcc 643Arg Leu Leu Pro Gln Ala Ala Arg Ala Val Ser Ser Asn Pro Glu Ala

170 175 180tac att tac ctg gct gat tcc atc cgc gca tgg cct agc cag gcg gaa 691Tyr Ile Tyr Leu Ala Asp Ser Ile Arg Ala Trp Pro Ser Gln Ala Glu

185 190 195cta gca cgg gag atc aac cag aat ggt tgg tca gat tgc ggt tgg cag 739Leu Ala Arg Glu Ile Asn Gln Asn Gly Trp Ser Asp Cys Gly Trp Gln

200 205 210aac ctg acc ttc ggc atc gtc gcg ctg cac tcg gcg att aaa cca gag 787Asn Leu Thr Phe Gly Ile Val Ala Leu His Ser Ala Ile Lys Pro Glu

215220225 aac tagtcgagtc ccacagaggg gag 813Asn230<210>890<211>230<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>890Val Ala Lys Ala Asp Leu Asp Lys Asp Pro Phe Asp Val Ala Ser Met 151015 Phe Asp Asp Val Gly Lys Asn Tyr Asp Leu Thr Asn Thr Val Leu Ser

20 25 30Phe Gly Gln Asp Arg Val Trp Arg Lys Arg Thr Arg Gln Arg Leu Asp

35 40 45Leu Lys Pro Gly Glu Lys Val Leu Asp Leu Ala Ala Gly Thr Ala Val

50 55 60Ser Thr Val Glu Leu Ala Lys Ser Gly Ala Phe Cys Val Ala Cys Asp 65 70 75 80Phe Ser Gln Gly Met Leu Ala Ala Gly Lys Asp Arg Asp Val Ser Lys

85 90 95Val Val Gly Asp Gly Met Gln Leu Pro Phe Ala Asp Asn Ser Phe Asp

100 105 110Ala Val Thr Ile Ser Tyr Gly Leu Arg Asn Ile His Asp Phe Arg Ala

115 120 125Gly Leu Lys Glu Met Ala Arg Val Thr Lys Pro Gly Gly Arg Leu Thr

130 135 140Val Ala Glu Phe Ser Thr Pro Val Ile Pro Val Phe Gly Thr Val Tyr145 150 155 160Lys Glu Tyr Leu Met Arg Leu Leu Pro Gln Ala Ala Arg Ala Val Ser

165 170 175Ser Asn Pro Glu Ala Tyr Ile Tyr Leu Ala Asp Ser Ile Arg Ala Trp

180 185 190Pro Ser Gln Ala Glu Leu Ala Arg Glu Ile Asn Gln Asn Gly Trp Ser

195 200 205Asp Cys Gly Trp Gln Asn Leu Thr Phe Gly Ile Val Ala Leu His Ser

210215220 Ala Ile Lys Pro Glu Asn 225230<210>891<211>876<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (853)<223>RXN02912<400>891catcggtgtc ggttcactga tggtggccaa gaaggttgga taacagggtt aatcttgggt 60gatattgaaa tgacgtattc ctgattgggc tgaaaaatct gtg aca tca cct gaa 115

Val Thr Ser Pro Glu

1 5tta caa aac atc ctt aac aat tat tgg agc ggc agg gca gag gct tac 163Leu Gln Asn Ile Leu Asn Asn Tyr Trp Ser Gly Arg Ala Glu Ala Tyr

10 15 20cac ctc aac caa acc caa agc gag cgt gca caa ttt gaa cgc ccc atc 211His Leu Asn Gln Thr Gln Ser Glu Arg Ala Gln Phe Glu Arg Pro Ile

25 30 35tgg gaa aag gtg tgg tcg aag gct ttg cct atc gtg tcg gaa gaa gcg 259Trp Glu Lys Val Trp Ser Lys Ala Leu Pro Ile Val Ser Glu Glu Ala

40 45 50gta aag gtt ctc gat ctt ggc tgt ggc gct ggt tat gtc acc cac ctt 307Val Lys Val Leu Asp Leu Gly Cys Gly Ala Gly Tyr Val Thr His Leu

55 60 65cta agc gat tgc gga tac gaa aca atc ggc gtt gat ggt tct gag gaa 355Leu Ser Asp Cys Gly Tyr Glu Thr Ile Gly Val Asp Gly Ser Glu Glu 70 75 80 85atg atc aat caa gct acg cag gag aat ggt ctt cgc agg tcg acg ggt 403Met Ile Asn Gln Ala Thr Gln Glu Asn Gly Leu Arg Arg Ser Thr Gly

90 95 100cgg gcg act gcc att ttt cag gtc ggg gat gcg cat gat ccc gag ttc 451Arg Ala Thr Ala Ile Phe Gln Val Gly Asp Ala His Asp Pro Glu Phe

105 110 115cgg gaa ggc tct ttt gat gcg ata acc agc cgg tat gtg ttg tgg act 499Arg Glu Gly Ser Phe Asp Ala Ile Thr Ser Arg Tyr Val Leu Trp Thr

120 125 130ctg ctg gat ccc cag gca gcg att aat cgt tgg gtg tct ttg cta aaa 547Leu Leu Asp Pro Gln Ala Ala Ile Asn Arg Trp Val Ser Leu Leu Lys

135 140 145cct ggt ggg gtt att gcg tgc gta gat gcg gct tgg tat ccg aag ggc 595Pro Gly Gly Val Ile Ala Cys Val Asp Ala Ala Trp Tyr Pro Lys Gly150 155 160 165att gat gct ggc acg gaa gta gat tca gtg gat ggt ccg agt gct ttc 643Ile Asp Ala Gly Thr Glu Val Asp Ser Val Asp Gly Pro Ser Ala Phe

170 175 180gta gag acc tat acc ccg gaa ctt ttg agg aat ctt ccc atg tca acg 691Val Glu Thr Tyr Thr Pro Glu Leu Leu Arg Asn Leu Pro Met Ser Thr

185 190 195acc tcc act ggc cac aat ttc gca gag ctt ttc cac aac gct ggc ctc 739Thr Ser Thr Gly His Asn Phe Ala Glu Leu Phe His Asn AlaGly Leu

200 205 210aaa gaa gtc aca ttg aca ccc att gag ggg ctg gct gaa ctt gac cag 787Lys Glu Val Thr Leu Thr Pro Ile Glu Gly Leu Ala Glu Leu Asp Gln

215 220 225cga ttt ggc ctc tca cca ggg cat gag tcg act ccg cag ttc cta ttc 835Arg Phe Gly Leu Ser Pro Gly His Glu Ser Thr Pro Gln Phe Leu Phe230 235 240 245agg gga att aaa tcc agt tagtgctgtt ttaagcggtc gag 876Arg Gly Ile Lys Ser Ser

250<210>892<211>251<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>892Val Thr Ser Pro Glu Leu Gln Asn Ile Leu Asn Asn Tyr Trp Ser Gly 151015 Arg Ala Glu Ala Tyr His Leu Asn Gln Thr Gln Ser Glu Arg Ala Gln

20 25 30Phe Glu Arg Pro Ile Trp Glu Lys Val Trp Ser Lys Ala Leu Pro Ile

35 40 45Val Ser Glu Glu Ala Val Lys Val Leu Asp Leu Gly Cys Gly Ala Gly

50 55 60Tyr Val Thr His Leu Leu Ser Asp Cys Gly Tyr Glu Thr Ile Gly Val 65 70 75 80Asp Gly Ser Glu Glu Met Ile Asn Gln Ala Thr Gln Glu Asn Gly Leu

85 90 95Arg Arg Ser Thr Gly Arg Ala Thr Ala Ile Phe Gln Val Gly Asp Ala

100 105 110His Asp Pro Glu Phe Arg Glu Gly Ser Phe Asp Ala Ile Thr Ser Arg

115 120 125Tyr Val Leu Trp Thr Leu Leu Asp Pro Gln Ala Ala Ile Asn Arg Trp

130 135 140Val Ser Leu Leu Lys Pro Gly Gly Val Ile Ala Cys Val Asp Ala Ala145 150 155 160Trp Tyr Pro Lys Gly Ile Asp Ala Gly Thr Glu Val Asp Ser Val Asp

165 170 175Gly Pro Ser Ala Phe Val Glu Thr Tyr Thr Pro Glu Leu Leu Arg Asn

180 185 190Leu Pro Met Ser Thr Thr Ser Thr Gly His Asn Phe Ala Glu Leu Phe

195 200 205His Asn Ala Gly Leu Lys Glu Val Thr Leu Thr Pro Ile Glu Gly Leu

210 215 220Ala Glu Leu Asp Gln Arg Phe Gly Leu Ser Pro Gly His Glu Ser Thr225 230 235 240Pro Gln Phe Leu Phe Arg Gly Ile Lys Ser Ser

245250<210>893<211>585<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (562)<223>RXS00998<400>893aatcggccta aaaggtgtga ccatttgggg gtagtggcga ttttaccagg tcacaggagg 60tgaaaatcca accattttag gccgactaga gtaattaatt atg act tcc cgc gat 115

Met Thr Ser Arg Asp

1 5gat caa ccc caa gat ctg ctt tcg ctt gca gaa ctt gcc gcc acc aga 163Asp Gln Pro Gln Asp Leu Leu Ser Leu Ala Glu Leu Ala Ala Thr Arg

10 15 20gct tta acc aca gac gaa ctt gaa gca ctc aac aac gcc aat tat ggc 211Ala Leu Thr Thr Asp Glu Leu Glu Ala Leu Asn Asn Ala Asn Tyr Gly

25 30 35ctc gac cgc aat ctg ggg ctg cgc tac acc acc atc gag ccc ggc cgg 259Leu Asp Arg Asn Leu Gly Leu Arg Tyr Thr Thr Ile Glu Pro Gly Arg

40 45 50gtg gtc agc gaa ctt cac gtg gca tcc aag cac ctg caa gtg gtg ggc 307Val Val Ser Glu Leu His Val Ala Ser Lys His Leu Gln Val Val Gly

55 60 65ttg gtc aac ggt ggt gtc tac gcc gcc atc gcc gaa tcc act gga tca 355Leu Val Asn Gly Gly Val Tyr Ala Ala Ile Ala Glu Ser Thr Gly Ser 70 75 80 85gtc gcc agc atg att tcc gcc cct gga aaa atg gtc gtc ggc atc aac 403Val Ala Ser Met Ile Ser Ala Pro Gly Lys Met Val Val Gly Ile Asn

90 95 100aac aac acc gac ttc att tct gct gtg agc tcc ggt gtc atc gtg gcc 451Asn Asn Thr Asp Phe Ile Ser Ala Val Ser Ser Gly Val Ile Val Ala

105 110 115gaa gca acg ccg att cag cta ggt ggc cgc acc cat ctg tgg cag atc 499Glu Ala Thr Pro Ile Gln Leu Gly Gly Arg Thr His Leu Trp Gln Ile

120 125 130gaa tgc acc cac cgc gga gaa gtc gtc gca cga acc aca ctg cgc acc 547Glu Cys Thr His Arg Gly Glu Val Val Ala Arg Thr Thr Leu Arg Thr

135140145 atg gtg ctg aac aag tagccctata ctcgggcacc atg 585Met Val Leu Asn Lys150<210>894<211>154<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>894Met Thr Ser Arg Asp Asp Gln Pro Gln Asp Leu Leu Ser Leu Ala Glu 151015 Leu Ala Ala Thr Arg Ala Leu Thr Thr Asp Glu Leu Glu Ala Leu Asn

20 25 30Asn Ala Asn Tyr Gly Leu Asp Arg Asn Leu Gly Leu Arg Tyr Thr Thr

35 40 45Ile Glu Pro Gly Arg Val Val Ser Glu Leu His Val Ala Ser Lys His

50 55 60Leu Gln Val Val Gly Leu Val Asn Gly Gly Val Tyr Ala Ala Ile Ala 65 70 75 80Glu Ser Thr Gly Ser Val Ala Ser Met Ile Ser Ala Pro Gly Lys Met

85 90 95Val Val Gly Ile Asn Asn Asn Thr Asp Phe Ile Ser Ala Val Ser Ser

100 105 110Gly Val Ile Val Ala Glu Ala Thr Pro Ile Gln Leu Gly Gly Arg Thr

115 120 125His Leu Trp Gln Ile Glu Cys Thr His Arg Gly Glu Val Val Ala Arg

130135140 Thr Thr Leu Arg Thr Met Val Leu Asn Lys 145150<210>895<211>1098<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220>CDS<222>(101). (1075)<223>RXA01215<400>895tcgaaggctg ggtgcaaaag aagcgccctg gaaccgctgc agcacaagcc gcagaagccg 60cccaaaacgt ccacaaccag gaaggctaag caggatcctc atg act gct cac tgg 115

Met Thr Ala His Trp

1 5aaa caa aac caa aag aac ctc atg ctg ttt tcg ggt cgt gcg cac cca 163Lys Gln Asn Gln Lys Asn Leu Met Leu Phe Ser Gly Arg Ala His Pro

10 15 20gaa ctg gca gaa gct gta gct aaa gag ctc gac gtc aac gtc acc cca 211Glu Leu Ala Glu Ala Val Ala Lys Glu Leu Asp Val Asn Val Thr Pro

25 30 35atg acg gca cgc gat ttc gcc aac ggt gaa atc tac gtc cgc ttc gag 259Met Thr Ala Arg Asp Phe Ala Asn Gly Glu Ile Tyr Val Arg Phe Glu

40 45 50gaa tca gtt cgt ggc tcc gac tgc ttc gtc ctg cag tcc cac acc cag 307Glu Ser Val Arg Gly Ser Asp Cys Phe Val Leu Gln Ser His Thr Gln

55 60 65cct ctc aac aag tgg ctc atg gaa cag ctg ctg atg atc gac gct ttg 355Pro Leu Asn Lys Trp Leu Met Glu Gln Leu Leu Met Ile Asp Ala Leu 70 75 80 85aag cgt ggt tcc gca aag cgc atc acc gcg atc ctg ccg ttc tac cca 403Lys Arg Gly Ser Ala Lys Arg Ile Thr Ala Ile Leu Pro Phe Tyr Pro

90 95 100tat gcc cgc cag gac aag aag cac cgc ggc cgc gag cca att tct gct 451Tyr Ala Arg Gln Asp Lys Lys His Arg Gly Arg Glu Pro Ile Ser Ala

105 110 115cgc ctc atc gcc gac ctc atg ctc acc gct ggc gcg gac cgt atc gtg 499Arg Leu Ile Ala Asp Leu Met Leu Thr Ala Gly Ala Asp Arg Ile Val

120 125 130tcc gtg gac ttg cac acc gat cag atc cag ggc ttc ttc gac ggc cca 547Ser Val Asp Leu His Thr Asp Gln Ile Gln Gly Phe Phe Asp Gly Pro

135 140 145gtc gat cac atg cac gcc atg ccg atc ctc acc gat cac atc aag gaa 595Val Asp His Met His Ala Met Pro Ile Leu Thr Asp His Ile Lys Glu150 155 160 165aac tac aac ctg gac aac atc tgc gtg gtc tcc cct gac gca ggt cgc 643Asn Tyr Asn Leu Asp Asn Ile Cys Val Val Ser Pro Asp Ala Gly Arg

170 175 180gtg aag gtt gca gag aag tgg gct aac acc ttg ggc gat gcc cca atg 691Val Lys Val Ala Glu Lys Trp Ala Asn Thr Leu Gly Asp Ala Pro Met

185 190 195gcg ttc gtg cac aag acc cgc tcc acc gag gta gca aac cag gtt gtc 739Ala Phe Val His Lys Thr Arg Ser Thr Glu Val Ala Asn Gln Val Val

200 205 210gcc aac cgc gtc gtc ggt gac gtc gac ggc aag gac tgc gtg ctt ctc 787Ala Asn Arg Val Val Gly Asp Val Asp Gly Lys Asp Cys Val Leu Leu

215 220 225gac gac atg atc gac act ggc ggc acc atc gcc ggc gct gtg ggc gtc 835Asp Asp Met Ile Asp Thr Gly Gly Thr Ile Ala Gly Ala Val Gly Val230 235 240 245ctg aag aag gct ggc gca aag tca gtc gtc atc gcc tgc acc cac ggt 883Leu Lys Lys Ala Gly Ala Lys Ser Val Val Ile Ala Cys Thr His Gly

250 255 260gtg ttc tct gac cca gcc cgc gag cgc ctg tct gca tgc ggt gct gaa 931Val Phe Ser Asp Pro Ala Arg Glu Arg Leu Ser Ala Cys Gly Ala Glu

265 270 275gaa gtc atc acc acc gac acc ctg cca cag tcc acc gag ggc tgg agc 979Glu Val Ile Thr Thr Asp Thr Leu Pro Gln Ser Thr Glu Gly Trp Ser

280 285 290aac ctg acc gtt ttg tcg atc gca ccg ctg ctg gct cgc acc atc aac 1027Asn Leu Thr Val Leu Ser Ile Ala Pro Leu Leu Ala Arg Thr Ile Asn

295300305 gag atc ttc gaa aac ggt tcc gtc acc acc ctc ttc gag ggc gag gcc 1075Glu Ile Phe Glu Asn Gly Ser Val Thr Thr Leu Phe Glu Gly Glu Ala 310315320325 taaacaccca tgcccaccac gga 1098<210>896<211>325<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>896Met Thr Ala His Trp Lys Gln Asn Gln Lys Asn Leu Met Leu Phe Ser 151015 Gly Arg Ala His Pro Glu Leu Ala Glu Ala Val Ala Lys Glu Leu Asp

20 25 30Val Asn Val Thr Pro Met Thr Ala Arg Asp Phe Ala Asn Gly Glu Ile

35 40 45Tyr Val Arg Phe Glu Glu Ser Val Arg Gly Ser Asp Cys Phe Val Leu

50 55 60Gln Ser His Thr Gln Pro Leu Asn Lys Trp Leu Met Glu Gln Leu Leu 65 70 75 80Met Ile Asp Ala Leu Lys Arg Gly Ser Ala Lys Arg Ile Thr Ala Ile

85 90 95Leu Pro Phe Tyr Pro Tyr Ala Arg Gln Asp Lys Lys His Arg Gly Arg

100 105 110Glu Pro Ile Ser Ala Arg Leu Ile Ala Asp Leu Met Leu Thr Ala Gly

115 120 125Ala Asp Arg Ile Val Ser Val Asp Leu His Thr Asp Gln Ile Gln Gly

130 135 140Phe Phe Asp Gly Pro Val Asp His Met His Ala Met Pro Ile Leu Thr145 150 155 160Asp His Ile Lys Glu Asn Tyr Asn Leu Asp Asn Ile Cys Val Val Ser

165 170 175Pro Asp Ala Gly Arg Val Lys Val Ala Glu Lys Trp Ala Asn Thr Leu

180 185 190Gly Asp Ala Pro Met Ala Phe Val His Lys Thr Arg Ser Thr Glu Val

195 200 205Ala Asn Gln Val Val Ala Asn Arg Val Val Gly Asp Val Asp Gly Lys

210 215 220

Asp Cys Val Leu Leu Asp Asp Met Ile Asp Thr Gly Gly Thr Ile Ala225 230 235 240Gly Ala Val Gly Val Leu Lys Lys Ala Gly Ala Lys Ser Val Val Ile

245 250 255Ala Cys Thr His Gly Val Phe Ser Asp Pro Ala Arg Glu Arg Leu Ser

260 265 270Ala Cys Gly Ala Glu Glu Val Ile Thr Thr Asp Thr Leu Pro Gln Ser

275 280 285Thr Glu Gly Trp Ser Asn Leu Thr Val Leu Ser Ile Ala Pro Leu Leu

290 295 300Ala Arg Thr Ile Asn Glu Ile Phe Glu Asn Gly Ser Val Thr Thr Leu305 310 315 320Phe Glu Gly Glu Ala

325<210>897<211>1470<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1447)<223>RXN00558<400>897gaacaggcac cgcaggaaga atgcggcgtt ttcggcgttt gggcgccagg tgaggaagtc 60tcgaaactta cctactttgg cctcttcgca cttcagcacc gtg gtc aag aag ccc 115

Val Val Lys Lys Pro

1 5gcg ggc atc gca gta ggc gat ggc gaa cag atc ctg gtt ttc aaa gat 163Ala Gly Ile Ala Val Gly Asp Gly Glu Gln Ile Leu Val Phe Lys Asp

10 15 20ttg ggc cta gtc tcc caa gtt ttc gac caa cca att ctg gaa tcc ctc 211Leu Gly Leu Val Ser Gln Val Phe Asp Gln Pro Ile Leu Glu Ser Leu

25 30 35cgc gga aac atc gcc atc gga cac acc cga tac acc acc gcc ggc gga 259Arg Gly Asn Ile Ala Ile Gly His Thr Arg Tyr Thr Thr Ala Gly Gly

40 45 50aac acc tgg gaa aat gcc cag cct atg ttc cgc atg gca cca gat ggc 307Asn Thr Trp Glu Asn Ala Gln Pro Met Phe Arg Met Ala Pro Asp Gly

55 60 65acc gat atc gcc ctt gga cac aac ggc aac ctg att aat tac atc gag 355Thr Asp Ile Ala Leu Gly His Asn Gly Asn Leu Ile Asn Tyr Ile Glu 70 75 80 85ttg ttg gac aaa gcc acc gaa ctt ggc ctc gtc gat ccc gcc aag aag 403Leu Leu Asp Lys Ala Thr Glu Leu Gly Leu Val Asp Pro Ala Lys Lys

90 95 100cca tca gat acc gat gtg ctc act gga ctg ctc gca agc ggc gtc cat 451Pro Ser Asp Thr Asp Val Leu Thr Gly Leu Leu Ala Ser Gly Val His

105 110 115gac gga aat aat ctc ttt gat tcc gcc aag gaa ctc ctc ccc agc gtc 499Asp Gly Asn Asn Leu Phe Asp Ser Ala Lys Glu Leu Leu Pro Ser Val

120 125 130aag gga gcc tac tgc ctc acc ttc acc gac gga cac acc ctg tac gca 547Lys Gly Ala Tyr Cys Leu Thr Phe Thr Asp Gly His Thr Leu Tyr Ala

135 140 145gcg cgt gat cca ttc ggc atc cgc cca ctg tcc atc ggc cgc ctc gag 595Ala Arg Asp Pro Phe Gly Ile Arg Pro Leu Ser Ile Gly Arg Leu Glu150 155 160 165cgc ggc tgg gta gtc gca tct gaa acc gca gcg ctc gac atc gta ggt 643Arg Gly Trp Val Val Ala Ser Glu Thr Ala Ala Leu Asp Ile Val Gly

170 175 180gcc tcg cat gtg cgc gag gtc gaa cca ggc gaa ctg att gct atc gac 691Ala Ser His Val Arg Glu Val Glu Pro Gly Glu Leu Ile Ala Ile Asp

185 190 195gaa tcc ggc ctc aag tcc gca cga ttc gcc gag aca acc cgc aaa ggt 739Glu Ser Gly Leu Lys Ser Ala Arg Phe Ala Glu Thr Thr Arg Lys Gly

200 205 210tgc gtc ttc gaa tac gtt tac ctg gct cgt cca gac tcc gtg atc aag 787Cys Val Phe Glu Tyr Val Tyr Leu Ala Arg Pro Asp Ser Val Ile Lys

215220 225gga aga aac gtc aac gaa gcc cga ctt gaa atc ggc cgc aag ctc gct 835Gly Arg Asn Val Asn Glu Ala Arg Leu Glu Ile Gly Arg Lys Leu Ala230 235 240 245gca gaa gca cca gca gtc ggc gat cta gtc atc cca acc cca gaa tca 883Ala Glu Ala Pro Ala Val Gly Asp Leu Val Ile Pro Thr Pro Glu Ser

250 255 260ggc acc cca gca gca gtt gga ttc gcc caa gca tct ggc atc cca ttc 931Gly Thr Pro Ala Ala Val Gly Phe Ala Gln Ala Ser Gly Ile Pro Phe

265 270 275ggc caa ggc atg gtc aaa aac gcc tac gtt ggc cga acc ttc atc cag 979Gly Gln Gly Met Val Lys Asn Ala Tyr Val Gly Arg Thr Phe Ile Gln

280 285 290cct tcc gac act ctc cgc caa ctg gga atc cgc ctc aag ctg aac cca 1027Pro Ser Asp Thr Leu Arg Gln Leu Gly Ile Arg Leu Lys Leu Asn Pro

295 300 305ttg cgc gag gtt atc gcc gga aag cgc ctt gtg gtt gtg gat gat tcc 1075Leu Arg Glu Val Ile Ala Gly Lys Arg Leu Val Val Val Asp Asp Ser310 315 320 325atc gtc cgc ggt aac acc caa cgc gcc gtg atc cgc atg ttg cgc gaa 1123Ile Val Arg Gly Asn Thr Gln Arg Ala Val Ile Arg Met Leu Arg Glu

330 335 340gcc ggt gca gct gag gtt cac gta cgc atc gcc tca cca ccc gtg aaa 1171Ala Gly Ala Ala Glu Val His Val Arg Ile Ala Ser Pro Pro Val Lys

345 350 355tgg cca tgc ttc tac ggc atc gat ttt gcc acc cca ggc gaa ctc att 1219Trp Pro Cys Phe Tyr Gly Ile Asp Phe Ala Thr Pro Gly Glu Leu Ile

360 365 370gcc aac gct gtc acc agt gac aac gaa gca gaa atg gtagaa gca gtc 1267Ala Asn Ala Val Thr Ser Asp Asn Glu Ala Glu Met Val Glu Ala Val

375 380 385cgc tcc gca atc ggc gca gac acc ctc ggc tac gtc tcc atc gac tcc 1315Arg Ser Ala Ile Gly Ala Asp Thr Leu Gly Tyr Val Ser Ile Asp Ser390 395 400 405atg gtt gca gca acc gag caa cca gcc aac gaa ctc tgc atc gcc tgc 1363Met Val Ala Ala Thr Glu Gln Pro Ala Asn Glu Leu Cys Ile Ala Cys

410 415 420ttc gac ggc aaa tac ccc atg ggt ctg cca cag gga aac agc aac gca 1411Phe Asp Gly Lys Tyr Pro Met Gly Leu Pro Gln Gly Asn Ser Asn Ala

425 430 435gac cta gtc cgc aag atg caa gca acc gcc tca agt taagatcggt 1457Asp Leu Val Arg Lys Met Gln Ala Thr Ala Ser Ser

440445 aggcgatagg ggt 1470<210>898<211>449<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>898Val Val Lys Lys Pro Ala Gly Ile Ala Val Gly Asp Gly Glu Gln Ile 151015 Leu Val Phe Lys Asp Leu Gly Leu Val Ser Gln Val Phe Asp Gln Pro

20 25 30Ile Leu Glu Ser Leu Arg Gly Asn Ile Ala Ile Gly His Thr Arg Tyr

35 40 45Thr Thr Ala Gly Gly Asn Thr Trp Glu Asn Ala Gln Pro Met Phe Arg

50 55 60Met Ala Pro Asp Gly Thr Asp Ile Ala Leu Gly His Asn Gly Asn Leu 65 70 75 80Ile Asn Tyr Ile Glu Leu Leu Asp Lys Ala Thr Glu Leu Gly Leu Val

85 90 95Asp Pro Ala Lys Lys Pro Ser Asp Thr Asp Val Leu Thr Gly Leu Leu

100 105 110Ala Ser Gly Val His Asp Gly Asn Asn Leu Phe Asp Ser Ala Lys Glu

115 120 125Leu Leu Pro Ser Val Lys Gly Ala Tyr Cys Leu Thr Phe Thr Asp Gly

130 135 140His Thr Leu Tyr Ala Ala Arg Asp Pro Phe Gly Ile Arg Pro Leu Ser145 150 155 160Ile Gly Arg Leu Glu Arg Gly Trp Val Val Ala Ser Glu Thr Ala Ala

165 170 175Leu Asp Ile Val Gly Ala Ser His Val Arg Glu Val Glu Pro Gly Glu

180 185 190Leu Ile Ala Ile Asp Glu Ser Gly Leu Lys Ser Ala Arg Phe Ala Glu

195 200 205Thr Thr Arg Lys Gly Cys Val Phe Glu Tyr Val Tyr Leu Ala Arg Pro

210 215 220Asp Ser Val Ile Lys Gly Arg Asn Val Asn Glu Ala Arg Leu Glu Ile225 230 235 240Gly Arg Lys Leu Ala Ala Glu Ala Pro Ala Val Gly Asp Leu Val Ile

245 250 255Pro Thr Pro Glu Ser Gly Thr Pro Ala Ala Val Gly Phe Ala Gln Ala

260 265 270Ser Gly Ile Pro Phe Gly Gln Gly Met Val Lys Asn Ala Tyr Val Gly

275 280 285Arg Thr Phe Ile Gln Pro Ser Asp Thr Leu Arg Gln Leu Gly Ile Arg

290 295 300Leu Lys Leu Asn Pro Leu Arg Glu Val Ile Ala Gly Lys Arg Leu Val305 310 315 320Val Val Asp Asp Ser Ile Val Arg Gly Asn Thr Gln Arg Ala Val Ile

325 330 335Arg Met Leu Arg Glu Ala Gly Ala Ala Glu Val His Val Arg Ile Ala

340 345 350Ser Pro Pro Val Lys Trp Pro Cys Phe Tyr Gly Ile Asp Phe Ala Thr

355 360 365Pro Gly Glu Leu Ile Ala Asn Ala Val Thr Ser Asp Asn Glu Ala Glu

370 375 380Met Val Glu Ala Val Arg Ser Ala Ile Gly Ala Asp Thr Leu Gly Tyr385 390 395 400Val Ser Ile Asp Ser Met Val Ala Ala Thr Glu Gln Pro Ala Asn Glu

405 410 415Leu Cys Ile Ala Cys Phe Asp Gly Lys Tyr Pro Met Gly Leu Pro Gln

420 425 430Gly Asn Ser Asn Ala Asp Leu Val Arg Lys Met Gln Ala Thr Ala Ser

435440445 Ser<210>899<211>524<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(61) } (501)<223>FRXA00558<400>899gggcgccagg tgaggaagta tcgcagctca cctactttgg cctcttcgca gttcagcacc 60gtg gtc aag aag ccc gcg ggc atc gca gta ggc gat ggc gaa cag atc 108Val Val Lys Lys Pro Ala Gly Ile Ala Val Gly Asp Gly Glu Gln Ile 151015 ctg gtt ttc aaa gat ttg ggc cta gtc tcc caa gtt ttc gac caa cca 156Leu Val Phe Lys Asp Leu Gly Leu Val Ser Gln Val Phe Asp Gln Pro

20 25 30att ctg gaa tcc ctc cgc gga aac atc gcc atc gga cac acc cga tac 204Ile Leu Glu Ser Leu Arg Gly Asn Ile Ala Ile Gly His Thr Arg Tyr

35 40 45acc acc gcc ggc gga aac acc tgg gaa aat gcc cag cct atg ttc cgc 252Thr Thr Ala Gly Gly Asn Thr Trp Glu Asn Ala Gln Pro Met Phe Arg

50 55 60atg gca cca gat ggc acc gat atc gcc ctt gga cac aac ggc aac ctg 300Met Ala Pro Asp Gly Thr Asp Ile Ala Leu Gly His Asn Gly Asn Leu 65 70 75 80att aat tac atc gag ttg ttg gac aaa gcc acc gaa ctt ggc ctc gtc 348Ile Asn Tyr Ile Glu Leu Leu Asp Lys Ala Thr Glu Leu Gly Leu Val

85 90 95gat ccc gcc aag aag cca tca gat acc gat gtg ctc act gga ctg ctc 396Asp Pro Ala Lys Lys Pro Ser Asp Thr Asp Val Leu Thr Gly Leu Leu

100 105 110gca agc ggc gtc cat gac gga aat aat ctc ttt gat tcc gcc aag gaa 444Ala Ser Gly Val His Asp Gly Asn Asn Leu Phe Asp Ser Ala Lys Glu

115 120 125ctc ctc ccc agc gtc aag gga gcc tac tgc ctc acc ttc acc gac gga 492Leu Leu Pro Ser Val Lys Gly Ala Tyr Cys Leu Thr Phe Thr Asp Gly

130135140 cac acc ctg taagcagcgc gtgatccatt cgg 524His Thr Leu145<210>900<211>147<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>900Val Val Lys Lys Pro Ala Gly Ile Ala Val Gly Asp Gly Glu Gln Ile 151015 Leu Val Phe Lys Asp Leu Gly Leu Val Ser Gln Val Phe Asp Gln Pro

20 25 30Ile Leu Glu Ser Leu Arg Gly Asn Ile Ala Ile Gly His Thr Arg Tyr

35 40 45Thr Thr Ala Gly Gly Asn Thr Trp Glu Asn Ala Gln Pro Met Phe Arg

50 55 60Met Ala Pro Asp Gly Thr Asp Ile Ala Leu Gly His Asn Gly Asn Leu 65 70 75 80Ile Asn Tyr Ile Glu Leu Leu Asp Lys Ala Thr Glu Leu Gly Leu Val

85 90 95Asp Pro Ala Lys Lys Pro Ser Asp Thr Asp Val Leu Thr Gly Leu Leu

100 105 110Ala Ser Gly Val His Asp Gly Asn Asn Leu Phe Asp Ser Ala Lys Glu

115 120 125Leu Leu Pro Ser Val Lys Gly Ala Tyr Cys Leu Thr Phe Thr Asp Gly

130135140 His Thr Leu145<210>901<211>1386<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1363)<223>RXN00626<400>901tcattttaag gcgcttttcg acgccacttt caaccatttc cgaaccgcca agaatactgg 60aatagcttgg atcaagtttt gcaggataaa ctgtgcaacc atg cgc att ctg gta 115

Met Arg Ile Leu Val

1 5atc ggc tcg ggc gcc cgt gag cac gcc ctc ctc cgt gga ctg tca act 163Ile Gly Ser Gly Ala Arg Glu His Ala Leu Leu Arg Gly Leu Ser Thr

10 15 20gac cct gca acc act gaa ctc cac gtt gcc cca ggt aac gct ggt ctt 211Asp Pro Ala Thr Thr Glu Leu His Val Ala Pro Gly Asn Ala Gly Leu

25 30 35gga tcg atc gca act gtc cac cct ggc atc aag gct gat gat cca gag 259Gly Ser Ile Ala Thr Val His Pro Gly Ile Lys Ala Asp Asp Pro Glu

40 45 50gct gtc act gcg ttg gct aaa gaa ctg aac tct gat ctg gtt gtt atc 307Ala Val Thr Ala Leu Ala Lys Glu Leu Asn Ser Asp Leu Val Val Ile

55 60 65ggc cca gag atc cct ttg gtt gcg ggt gtt gct gat gca ctt cgc gcg 355Gly Pro Glu Ile Pro Leu Val Ala Gly Val Ala Asp Ala LeuArg Ala 70 75 80 85gcg ggt atc gct gtg ttt ggt cct aac aag gac gct gct cgt atc gag 403Ala Gly Ile Ala Val Phe Gly Pro Asn Lys Asp Ala Ala Arg Ile Glu

90 95 100ggc tcc aag gct ttc gct aag gat gtc atg gct gcg cag ggt gtt cgt 451Gly Ser Lys Ala Phe Ala Lys Asp Val Met Ala Ala Gln Gly Val Arg

105 110 115act gct cat gct gag act att act cct ggt gcg tct tct gaa gat att 499Thr Ala His Ala Glu Thr Ile Thr Pro Gly Ala Ser Ser Glu Asp Ile

120 125 130gat gct gcc ata gat cgt ttc ggc cca acg tgg gtt gtc aag gat gat 547Asp Ala Ala Ile Asp Arg Phe Gly Pro Thr Trp Val Val Lys Asp Asp

135 140 145ggt ttg tct gcg ggc aag ggt gtt gtg gtt acc ccc gat cgt gca gca 595Gly Leu Ser Ala Gly Lys Gly Val Val Val Thr Pro Asp Arg Ala Ala150 155 160 165gca cgt gct cac gta gat gca gtg ctt gag ggc gga aat cca gtt ttg 643Ala Arg Ala His Val Asp Ala Val Leu Glu Gly Gly Asn Pro Val Leu

170 175 180ctg gag tcc ttc ctt gat ggc cct gag gtt tcc ctg ttc tgc ctg gtt 691Leu Glu Ser Phe Leu Asp Gly Pro Glu Val Ser Leu Phe Cys Leu Val

185 190 195gat ggc gag acg gta gtt cct ctg ctg cca gcg cag gat cac aag cgt 739Asp Gly Glu Thr Val Val Pro Leu Leu Pro Ala Gln Asp His Lys Arg

200 205 210gcg tac gac aac gat gag ggc cca aac act ggt ggc atg ggt gct tat 787Ala Tyr Asp Asn Asp Glu Gly Pro Asn Thr Gly Gly Met Gly Ala Tyr

215 220 225gcgccg ctt cct tgg ctg cct gaa gat ggc gtc cag cgc att gtc gat 835Ala Pro Leu Pro Trp Leu Pro Glu Asp Gly Val Gln Arg Ile Val Asp230 235 240 245gag gtc tgc gtt cct gtt gct cgt gag atg gtg gca cgt ggt tgc gcg 883Glu Val Cys Val Pro Val Ala Arg Glu Met Val Ala Arg Gly Cys Ala

250 255 260tac tcc ggt ctg ctt tac gca ggt atc gca tgg ggt gca gaa ggc cct 931Tyr Ser Gly Leu Leu Tyr Ala Gly Ile Ala Trp Gly Ala Glu Gly Pro

265 270 275gca gta gtg gag ttc aac tgc cgc ttc ggc gat cca gaa acc cag gct 979Ala Val Val Glu Phe Asn Cys Arg Phe Gly Asp Pro Glu Thr Gln Ala

280 285 290gta ctg gca cta ctg aag act cct cta gca gta ctg ctc aac gca gtt 1027Val Leu Ala Leu Leu Lys Thr Pro Leu Ala Val Leu Leu Asn Ala Val

295 300 305gct act gga acc ttg gca gag cag cca gca ctg gag tgg gag gat gct 1075Ala Thr Gly Thr Leu Ala Glu Gln Pro Ala Leu Glu Trp Glu Asp Ala310 315 320 325tac gcc ctg act gtg gtg ttg gct tct tac aac tac cca gag gca cct 1123Tyr Ala Leu Thr Val Val Leu Ala Ser Tyr Asn Tyr Pro Glu Ala Pro

330 335 340cgt act ggt gat gtc atc cgc aac gct gat gca gat aac gtt ctt cac 1171Arg Thr Gly Asp Val Ile Arg Asn Ala Asp Ala Asp Asn Val Leu His

345 350 355gct ggt acc gca ctc aat gct gaa ggc gag ctg gtc tct gcg ggc ggt 1219Ala Gly Thr Ala Leu Asn Ala Glu Gly Glu Leu Val Ser Ala Gly Gly

360 365 370cgt gtt ctt aac gtg atc ggt gtg ggt gag acc ctg gag gct gca cgc 1267Arg Val Leu Asn Val Ile Gly Val Gly Glu Thr Leu Glu Ala Ala Arg

375 380 385gat aac gcg tac acc acc atc aag gac att gaa ctt gag gga agc cac 1315Asp Asn Ala Tyr Thr Thr Ile Lys Asp Ile Glu Leu Glu Gly Ser His390 395 400 405tac cgc agc gat atc gca ttg gct gca tta gag ggt cgt atc tcg atc 1363Tyr Arg Ser Asp Ile Ala Leu Ala Ala Leu Glu Gly Arg Ile Ser Ile

410415420 taaaagcagt acgcagatag gct 1386<210>902<211>421<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>902Met Arg Ile Leu Val Ile Gly Ser Gly Ala Arg Glu His Ala Leu Leu 151015 Arg Gly Leu Ser Thr Asp Pro Ala Thr Thr Glu Leu His Val Ala Pro

20 25 30Gly Asn Ala Gly Leu Gly Ser Ile Ala Thr Val His Pro Gly Ile Lys

35 40 45Ala Asp Asp Pro Glu Ala Val Thr Ala Leu Ala Lys Glu Leu Asn Ser

50 55 60Asp Leu Val Val Ile Gly Pro Glu Ile Pro Leu Val Ala Gly Val Ala 65 70 75 80Asp Ala Leu Arg Ala Ala Gly Ile Ala Val Phe Gly Pro Asn Lys Asp

85 90 95Ala Ala Arg Ile Glu Gly Ser Lys Ala Phe Ala Lys Asp Val Met Ala

100 105 ll0Ala Gln Gly Val Arg Thr Ala His Ala Glu Thr Ile Thr Pro Gly Ala

115 120 125Ser Ser Glu Asp Ile Asp Ala Ala Ile Asp Arg Phe Gly Pro Thr Trp

130 135 140Val Val Lys Asp Asp Gly Leu Ser Ala Gly Lys Gly Val Val Val Thr145 150 155 160Pro Asp Arg Ala Ala Ala Arg Ala His Val Asp Ala Val Leu Glu Gly

165 170 175Gly Asn Pro Val Leu Leu Glu Ser Phe Leu Asp Gly Pro Glu Val Ser

180 185 190Leu Phe Cys Leu Val Asp Gly Glu Thr Val Val Pro Leu Leu Pro Ala

195 200 205Gln Asp His Lys Arg Ala Tyr Asp Asn Asp Glu Gly Pro Asn Thr Gly

210 215 220Gly Met Gly Ala Tyr Ala Pro Leu Pro Trp Leu Pro Glu Asp Gly Val225 230 235 240Gln Arg Ile Val Asp Glu Val Cys Val Pro Val Ala Arg Glu Met Val

245 250 255Ala Arg Gly Cys Ala Tyr Ser Gly Leu Leu Tyr Ala Gly Ile Ala Trp

260 265 270Gly Ala Glu Gly Pro Ala Val Val Glu Phe Asn Cys Arg Phe Gly Asp

275 280 285Pro Glu Thr Gln Ala Val Leu Ala Leu Leu Lys Thr Pro Leu Ala Val

290 295 300Leu Leu Asn Ala Val Ala Thr Gly Thr Leu Ala Glu Gln Pro Ala Leu305 310 315 320Glu Trp Glu Asp Ala Tyr Ala Leu Thr Val Val Leu Ala Ser Tyr Asn

325 330 335Tyr Pro Glu Ala Pro Arg Thr Gly Asp Val Ile Arg Asn Ala Asp Ala

340 345 350Asp Asn Val Leu His Ala Gly Thr Ala Leu Asn Ala Glu Gly Glu Leu

355 360 365Val Ser Ala Gly Gly Arg Val Leu Asn Val Ile Gly Val Gly Glu Thr

370375 380Leu Glu Ala Ala Arg Asp Asn Ala Tyr Thr Thr Ile Lys Asp Ile Glu385 390 395 400Leu Glu Gly Ser His Tyr Arg Ser Asp Ile Ala Leu Ala Ala Leu Glu

405 410 415Gly Arg Ile Ser Ile

420<210>903<211>364<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (364)<223>FRXA00629<400>903tcattttaag gcgcttttcg acgccacttt caaccatttc cgaaccgcca agaatactgg 60aatagcttgg atcaagtttt gcaggataaa ctgtgcaacc atg cgc att ctg gta 115

Met Arg Ile Leu Val

1 5atc ggc tcg ggc gcc cgt gag cac gcc ctc ctc cgt gga ctg tca act 163Ile Gly Ser Gly Ala Arg Glu His Ala Leu Leu Arg Gly Leu Ser Thr

10 15 20gac cct gca acc act gaa ctc cac gtt gcc cca ggt aac gct ggt ctt 211Asp Pro Ala Thr Thr Glu Leu His Val Ala Pro Gly Asn Ala Gly Leu

25 30 35gga tcg atc gca act gtc cac cct ggc atc aag gct gat gat cca gag 259Gly Ser Ile Ala Thr Val His Pro Gly Ile Lys Ala Asp Asp Pro Glu

40 45 50gct gtc act gcg ttg gct aaa gaa ctg aac tct gat ctg gtt gtt atc 307Ala Val Thr Ala Leu Ala Lys Glu Leu Asn Ser Asp Leu Val Val Ile

556065 ggc cca gag atc cct ttg gtt gcg ggt gtt gct gat gca ctt cgc gcg 355Gly Pro Glu Ile Pro Leu Val Ala Gly Val Ala Asp Ala Leu Arg Ala 70758085 gcg ggt atc 364Ala Gly Ile<210>904<211>88<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>904Met Arg Ile Leu Val Ile Gly Ser Gly Ala Arg Glu His Ala Leu Leu 151015 Arg Gly Leu Ser Thr Asp Pro Ala Thr Thr Glu Leu His Val Ala Pro

20 25 30Gly Asn Ala Gly Leu Gly Ser Ile Ala Thr Val His Pro Gly Ile Lys

35 40 45Ala Asp Asp Pro Glu Ala Val Thr Ala Leu Ala Lys Glu Leu Asn Ser

505560 Asp Leu Val Val Ile Gly Pro Glu Ile Pro Leu Val Ala Gly Val Ala 65707580 Asp Ala Leu Arg Ala Ala Gly Ile<210>905<211>803<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (780)<223>FRXA00626<400>905gat cgt gca gca gca cgt gct cac gta gat gca gtg ctt gag ggc gga 48Asp Arg Ala Ala Ala Arg Ala His Val Asp Ala Val Leu Glu Gly Gly 151015 aat cca gtt ttg ctg gag tcc ttc ctt gat ggc cct gag gtt tcc ctg 96Asn Pro Val Leu Leu Glu Ser Phe Leu Asp Gly Pro Glu Val Ser Leu

20 25 30ttc ttc ctg gtt gat ggc gag acg gta gtt cct ctg ctg cca gcg cag 144Phe Phe Leu Val Asp Gly Glu Thr Val Val Pro Leu Leu Pro Ala Gln

35 40 45gat cac aag cgt gcg tac gac aac gat gag ggc cca aac act ggt ggc 192Asp His Lys Arg Ala Tyr Asp Asn Asp Glu Gly Pro Asn Thr Gly Gly

50 55 60atg ggt gct tat gcg ccg ctt cct tgg ctg cct gaa gat ggc gtc cag 240Met Gly Ala Tyr Ala Pro Leu Pro Trp Leu Pro Glu Asp Gly Val Gln 65 70 75 80cgc att gtc gat gag gtc tgc gtt cct gtt gct cgt gag atg gtg gca 288Arg Ile Val Asp Glu Val Cys Val Pro Val Ala Arg Glu Met Val Ala

85 90 95cgt ggt tgc gcg tac tcc ggt ctg ctt tac gca ggt atc gca tgg ggt 336Arg Gly Cys Ala Tyr Ser Gly Leu Leu Tyr Ala Gly Ile Ala Trp Gly

100 105 110gca gaa ggc cct gca gta gtg gag ttc aac tgc cgc ttc ggc gat cca 384Ala Glu Gly Pro Ala Val Val Glu Phe Asn Cys Arg Phe Gly Asp Pro

115 120 125gaa acc cag gct gta ctg gca cta ctg aag act cct cta gca gta ctg 432Glu Thr Gln Ala Val Leu Ala Leu Leu Lys Thr Pro Leu Ala Val Leu

130 135 140ctc aac gca gtt gct act gga acc ttg gca gag cag cca gca ctg gag 480Leu Asn Ala Val Ala Thr Gly Thr Leu Ala Glu Gln Pro Ala Leu Glu145 150 155 160tgg gag gat gct tac gcc ctg act gtg gtg ttg gct tct tac aac tac 528Trp Glu Asp Ala Tyr Ala Leu Thr Val Val Leu Ala Ser Tyr Asn Tyr

165 170 175cca gag gca cct cgt act ggt gat gtc atc cgc aac gct gat gca gat 576Pro Glu Ala Pro Arg Thr Gly Asp Val Ile Arg Asn Ala Asp Ala Asp

180 185 190aac gtt ctt cac gct ggt acc gca ctc aat gct gaa ggc gag ctg gtc 624Asn Val Leu His Ala Gly Thr Ala Leu Asn Ala Glu Gly Glu Leu Val

195 200 205tct gcg ggc ggt cgt gtt ctt aac gtg atc ggt gtg ggt gag acc ctg 672Ser Ala Gly Gly Arg Val Leu Asn Val Ile Gly Val Gly Glu Thr Leu

210 215 220gag gct gca cgc gat aac gcg tac acc acc atc aag gac att gaa ctt 720Glu Ala Ala Arg Asp Asn Ala Tyr Thr Thr Ile Lys Asp Ile Glu Leu225 230 235 240gag gga agc cac tac cgc agc gat atc gca ttg gct gca tta gag ggt 768Glu Gly Ser His Tyr Arg Ser Asp Ile Ala Leu Ala Ala Leu Glu Gly

245 250 255cgt atc tcg atc taaaagcagt acgcagatag gct 803Arg Ile Ser Ile

260<210>906<211>260<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>906Asp Arg Ala Ala Ala Arg Ala His Val Asp Ala Val Leu Glu Gly Gly 151015 Asn Pro Val Leu Leu Glu Ser Phe Leu Asp Gly Pro Glu Val Ser Leu

20 25 30Phe Phe Leu Val Asp Gly Glu Thr Val Val Pro Leu Leu Pro Ala Gln

35 40 45Asp His Lys Arg Ala Tyr Asp Asn Asp Glu Gly Pro Asn Thr Gly Gly

50 55 60Met Gly Ala Tyr Ala Pro Leu Pro Trp Leu Pro Glu Asp Gly Val Gln 65 70 75 80Arg Ile Val Asp Glu Val Cys Val Pro Val Ala Arg Glu Met Val Ala

85 90 95Arg Gly Cys Ala Tyr Ser Gly Leu Leu Tyr Ala Gly Ile Ala Trp Gly

100 105 110Ala Glu Gly Pro Ala Val Val Glu Phe Asn Cys Arg Phe Gly Asp Pro

115 120 125Glu Thr Gln Ala Val Leu Ala Leu Leu Lys Thr Pro Leu Ala Val Leu

130 135 140Leu Asn Ala Val Ala Thr Gly Thr Leu Ala Glu Gln Pro Ala Leu Glu145 150 155 160Trp Glu Asp Ala Tyr Ala Leu Thr Val Val Leu Ala Ser Tyr Asn Tyr

165 170 175Pro Glu Ala Pro Arg Thr Gly Asp Val Ile Arg Asn Ala Asp Ala Asp

180 185 190Asn Val Leu His Ala Gly Thr Ala Leu Asn Ala Glu Gly Glu Leu Val

195 200 205Ser Ala Gly Gly Arg Val Leu Asn Val Ile Gly Val Gly Glu Thr Leu

210 215 220Glu Ala Ala Arg Asp Asn Ala Tyr Thr Thr Ile Lys Asp Ile Glu Leu225 230 235 240Glu Gly Ser His Tyr Arg Ser Asp Ile Ala Leu Ala Ala Leu Glu Gly

245 250 255Arg Ile Ser Ile

260<210>907<211>714<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (691)<223>RXA02623<400>907aatcctgaag aggaagaatc cgacgaagaa attgagacag aaactgaggc tgaagaaacc 60aatgatggtt ccgaggccga agaccgttaa catatctgtt gtg aat tct gac tct 115

Val Asn Ser Asp Ser

1 5acg acc acc att gtc gtg cta gct tcc gga aca ggc acc ctc ctt cag 163Thr Thr Thr Ile Val Val Leu Ala Ser Gly Thr Gly Thr Leu Leu Gln

10 15 20tca ctc att gaa gcg caa ggt acc tat tcg atc gtg ggc gtt gtc tct 211Ser Leu Ile Glu Ala Gln Gly Thr Tyr Ser Ile Val Gly Val Val Ser

25 30 35gac gtc gaa tgc cct gca ctt tcc aga gcc gca gat gca ggt att gat 259Asp Val Glu Cys Pro Ala Leu Ser Arg Ala Ala Asp Ala Gly Ile Asp

40 45 50act gca gtt gtt ccg ctt gga aaa gat cgt gca cag tgg aac cac gag 307Thr Ala Val Val Pro Leu Gly Lys Asp Arg Ala Gln Trp Asn His Glu

55 6065ctt gca gac gca gtt gca gta agc gac cca gat ttg gtg gtc tct gcg 355Leu Ala Asp Ala Val Ala Val Ser Asp Pro Asp Leu Val Val Ser Ala70 75 80 85gga ttc atg aaa att ttg ggc gaa ggt ttc ctc tca agg ttc ccg tcc 403Gly Phe Met Lys Ile Leu Gly Glu Gly Phe Leu Ser Arg Phe Pro Ser

90 95 100cgc atc atc aac acc cac cca gct tta ttg cct tct ttc cct ggt gcc 451Arg Ile Ile Asn Thr His Pro Ala Leu Leu Pro Ser Phe Pro Gly Ala

105 110 115cac gcg gtt cgc gat gct ttg gca tac ggt gtg aaa gtg tca ggt tcg 499His Ala Val Arg Asp Ala Leu Ala Tyr Gly Val Lys Val Ser Gly Ser

120 125 130aca gtt cac ctt gtc gat gct ggt gtg gat acc ggc cca att att gct 547Thr Val His Leu Val Asp Ala Gly Val Asp Thr Gly Pro Ile Ile Ala

135 140 145caa cga gca gtg ccg gta gaa gtg aat gat gat gaa tcc agc ctg cat 595Gln Arg Ala Val Pro Val Glu Val Asn Asp Asp Glu Ser Ser Leu His150 155 160 165gaa aga atc aag cag gtt gag cgt aaa ctc att gta gaa gtc ctg aac 643Glu Arg Ile Lys Gln Val Glu Arg Lys Leu Ile Val Glu Val Leu Asn

170 175 180agc gtg gaa ttt tcg cgt cag ggt ggc gta caa ctc aac tgg aga ggc 691Ser Val Glu Phe Ser Arg Gln Gly Gly Val Gln Leu Asn Trp Arg Gly

185190195 taaatccttc atgagcgatg atc 714<210>908<211>197<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>908Val Asn Ser Asp Ser Thr Thr Thr Ile Val Val Leu Ala Ser Gly Thr 151015 Gly Thr Leu Leu Gln Ser Leu Ile Glu Ala Gln Gly Thr Tyr Ser Ile

2025 30Val Gly Val Val Ser Asp Val Glu Cys Pro Ala Leu Ser Arg Ala Ala

35 40 45Asp Ala Gly Ile Asp Thr Ala Val Val Pro Leu Gly Lys Asp Arg Ala

50 55 60Gln Trp Asn His Glu Leu Ala Asp Ala Val Ala Val Ser Asp Pro Asp 65 70 75 80Leu Val Val Ser Ala Gly Phe Met Lys Ile Leu Gly Glu Gly Phe Leu

85 90 95Ser Arg Phe Pro Ser Arg Ile Ile Asn Thr His Pro Ala Leu Leu Pro

100 105 110Ser Phe Pro Gly Ala His Ala Val Arg Asp Ala Leu Ala Tyr Gly Val

115 120 125Lys Val Ser Gly Ser Thr Val His Leu Val Asp Ala Gly Val Asp Thr

130 135 140Gly Pro Ile Ile Ala Gln Arg Ala Val Pro Val Glu Val Asn Asp Asp145 150 155 160Glu Ser Ser Leu His Glu Arg Ile Lys Gln Val Glu Arg Lys Leu Ile

165 170 175Val Glu Val Leu Asn Ser Val Glu Phe Ser Arg Gln Gly Gly Val Gln

180 185 190Leu Asn Trp Arg Gly

195<210>909<211>1347<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1324)<223>RXA01442<400>909aattaagcaa cctttttaac aggtttagag ctttcacgag gtggcgtcag ataaagtgaa 60caccaatatt tctgacatct tccaacggag gctaaaaggc atg tac atc cca gag 115

Met Tyr Ile Pro Glu

1 5tcg atc ggc acc cct ttg acc ccc aat gcc acg aaa gtg atg ctg ctg 163Ser Ile Gly Thr Pro Leu Thr Pro Asn Ala Thr Lys Val Met Leu Leu

10 15 20gga tca gga gaa tta ggc aaa gaa gta gcc atc gct ttc cag cgt ctc 211Gly Ser Gly Glu Leu Gly Lys Glu Val Ala Ile Ala Phe Gln Arg Leu

25 30 35ggc ctg gaa gtc cat gca gtt gat cgc tac gaa cat gcc cca gcc cac 259Gly Leu Glu Val His Ala Val Asp Arg Tyr Glu His Ala Pro Ala His

40 45 50cag gtc gct cac ttc tcc tat gtc atc gac atg aca gat gca gcc cag 307Gln Val Ala His Phe Ser Tyr Val Ile Asp Met Thr Asp Ala Ala Gln

55 60 65gtg cgg gaa ttg gtg gag cgt gtg cgc cca gat ttt gtc att cct gaa 355Val Arg Glu Leu Val Glu Arg Val Arg Pro Asp Phe Val Ile Pro Glu 70 75 80 85atc gaa gca ctg gca acc gat gaa ctg gtg aag atc gaa gaa gag ggg 403Ile Glu Ala Leu Ala Thr Asp Glu Leu Val Lys Ile Glu Glu Glu Gly

90 95 100cta gct acc atc gtg ccc act gca cgt gca gcc aag ctg acc atg aac 451Leu Ala Thr Ile Val Pro Thr Ala Arg Ala Ala Lys Leu Thr Met Asn

105 110 115cgc gaa ggc atc cgc aag ctg gcg gca gag gaa ctg ggt ctt cca acc 499Arg Glu Gly Ile Arg Lys Leu Ala Ala Glu Glu Leu Gly Leu Pro Thr

120 125 130tcc aac tat gag ttc tgc tcc act ttc gag gaa ttc tcc gca gct gct 547Ser Asn Tyr Glu Phe Cys Ser Thr Phe Glu Glu Phe Ser Ala Ala Ala

135 140 145gaa aag ctt ggt tac ccc aac gtg gtg aaa cca gtg atg agt tct tcc 595Glu Lys Leu Gly Tyr Pro Asn Val Val Lys Pro Val Met Ser Ser Ser150 155 160 165ggc aag ggc caa tct gtt ttg cgt agt tca gac gat ctg cag gca gca 643Gly Lys Gly Gln Ser Val Leu Arg Ser Ser Asp Asp Leu Gln Ala Ala

170 175 180tgg gat tat gcg atg agc ggt gca cgc gtg gcc aac tcc cgc gtc atc 691Trp Asp Tyr Ala Met Ser Gly Ala Arg Val Ala Asn Ser Arg Val Ile

185 190 195gtg gaa gct ttc gtg gaa ttc gat tac gag atc acc ctg ttg aca gta 739Val Glu Ala Phe Val Glu Phe Asp Tyr Glu Ile Thr Leu Leu Thr Val

200 205 210agg tcc atc gat ccc acc acc tct aag cct gcg acc tgg ttc tgt gag 787Arg Ser Ile Asp Pro Thr Thr Ser Lys Pro Ala Thr Trp Phe Cys Glu

215 220 225ccc att ggg cac cgc caa gaa gac ggc gac tac gtg gaa tcc tgg cag 835Pro Ile Gly His Arg Gln Glu Asp Gly Asp Tyr Val Glu Ser Trp Gln230 235 240 245cca atg gag atg act cct cgc gcg ctg gaa aac gca cgc tca gta gcc 883Pro Met Glu Met Thr Pro Arg Ala Leu Glu Asn Ala Arg Ser Val Ala

250 255 260gca cgc atc acc aac gca ttg ggc gga cgc ggc gta ttt ggt gtg gag 931Ala Arg Ile Thr Asn Ala Leu Gly Gly Arg Gly Val Phe Gly Val Glu

265 270 275ctc ttt gtc tcc ggc gat gac gtg tac ttc tct gaa gtc tcc cca cgc 979Leu Phe Val Ser Gly Asp Asp Val Tyr Phe Ser Glu Val Ser Pro Arg

280 285 290cca cac gac acc ggc ctt gtc acc ctt gcc acc cag cgt ttc tct gaa 1027Pro His Asp Thr Gly Leu Val Thr Leu Ala Thr Gln Arg Phe Ser Glu

295 300 305ttt gaa ctc cac gcc aag gca att ctg gga ttg cct gtt gat gtc acc 1075Phe Glu Leu His Ala Lys Ala Ile Leu Gly Leu Pro Val Asp Val Thr310 315 320 325ctg att tct cca ggt gcc tcc gct gtc atc tac ggt ggc atc gaa tct 1123Leu Ile Ser Pro Gly Ala Ser Ala Val Ile Tyr Gly Gly Ile Glu Ser

330 335 340gaa ggc gtg agc tac acc ggg ttg gct gaa gcg ctg gca gtg gct gaa 1171Glu Gly Val Ser Tyr Thr Gly Leu Ala Glu Ala Leu Ala Val Ala Glu

345 350 355act gat ctt cgt atc ttt gcc aag cca gag gcc ttc acc aag cgt cgc 1219Thr Asp Leu Arg Ile Phe Ala Lys Pro Glu Ala Phe Thr Lys Arg Arg

360 365 370atg ggt gtt gca gtg tcc acc gct gag gat gtg gct gca gcc agg gac 1267Met Gly Val Ala Val Ser Thr Ala Glu Asp Val Ala Ala Ala Arg Asp

375380385 cgc gcc act ttg gct gcc gcg gcg atc aag gtt cat cca gga aat tcc 1315Arg Ala Thr Leu Ala Ala Ala Ala Ile Lys Val His Pro Gly Asn Ser 390395400405 gca gag gct taacatgctg ggaaagcatc ggg 1347Ala Glu Ala<210>910<211>408<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>910Met Tyr Ile Pro Glu Ser Ile Gly Thr Pro Leu Thr Pro Asn Ala Thr 151015 Lys Val Met Leu Leu Gly Ser Gly Glu Leu Gly Lys Glu Val Ala Ile

20 25 30Ala Phe Gln Arg Leu Gly Leu Glu Val His Ala Val Asp Arg Tyr Glu

35 40 45His Ala Pro Ala His Gln Val Ala His Phe Ser Tyr Val Ile Asp Met

50 55 60Thr Asp Ala Ala Gln Val Arg GluLeu Val Glu Arg Val Arg Pro Asp65 70 75 80Phe Val Ile Pro Glu Ile Glu Ala Leu Ala Thr Asp Glu Leu Val Lys

85 90 95Ile Glu Glu Glu Gly Leu Ala Thr Ile Val Pro Thr Ala Arg Ala Ala

100 105 110Lys Leu Thr Met Asn Arg Glu Gly Ile Arg Lys Leu Ala Ala Glu Glu

115 120 125Leu Gly Leu Pro Thr Ser Asn Tyr Glu Phe Cys Ser Thr Phe Glu Glu

130 135 140Phe Ser Ala Ala Ala Glu Lys Leu Gly Tyr Pro Asn Val Val Lys Pro145 150 155 160Val Met Ser Ser Ser Gly Lys Gly Gln Ser Val Leu Arg Ser Ser Asp

165 170 175Asp Leu Gln Ala Ala Trp Asp Tyr Ala Met Ser Gly Ala Arg Val Ala

180 185 190Asn Ser Arg Val Ile Val Glu Ala Phe Val Glu Phe Asp Tyr Glu Ile

195 200 205Thr Leu Leu Thr Val Arg Ser Ile Asp Pro Thr Thr Ser Lys Pro Ala

210 215 220Thr Trp Phe Cys Glu Pro Ile Gly His Arg Gln Glu Asp Gly Asp Tyr225 230 235 240Val Glu Ser Trp Gln Pro Met Glu Met Thr Pro Arg Ala Leu Glu Asn

245 250 255Ala Arg Ser Val Ala Ala Arg Ile Thr Asn Ala Leu Gly Gly Arg Gly

260 265 270Val Phe Gly Val Glu Leu Phe Val Ser Gly Asp Asp Val Tyr Phe Ser

275 280 285Glu Val Ser Pro Arg Pro His Asp Thr Gly Leu Val Thr Leu Ala Thr

290 295 300Gln Arg Phe Ser Glu Phe Glu Leu His Ala Lys Ala Ile Leu Gly Leu305 310 315 320Pro Val Asp Val Thr Leu Ile Ser Pro Gly Ala Ser Ala Val Ile Tyr

325 330 335Gly Gly Ile Glu Ser Glu Gly Val Ser Tyr Thr Gly Leu Ala Glu Ala

340 345 350Leu Ala Val Ala Glu Thr Asp Leu Arg Ile Phe Ala Lys Pro Glu Ala

355 360 365Phe Thr Lys Arg Arg Met Gly Val Ala Val Ser Thr Ala Glu Asp Val

370 375 380Ala Ala Ala Arg Asp Arg Ala Thr Leu Ala Ala Ala Ala Ile Lys Val385 390 395 400His Pro Gly Asn Ser Ala Glu Ala

405<210>911<211>2409<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (2386)<223>RXN00537<400>911acccggaaca tgccgtcgaa aagctaaccg gcccatctat tgatggcctg gagctgttcc 60tgtccgccgt tggcaccatc gcggcttaag aggagtaaat atg agc act ttt gtc 115

Met Ser Thr Phe Val

1 5aat gac acc gtc gaa gac gca atc aag acc cct gag ctg gat cag cca 163Asn Asp Thr Val Glu Asp Ala Ile Lys Thr Pro Glu Leu Asp Gln Pro

10 15 20ttt gag gct ctt ggt ctg aaa gac gac gag tac gcg cgc atc aag gaa 211Phe Glu Ala Leu Gly Leu Lys Asp Asp Glu Tyr Ala Arg Ile Lys Glu

2530 35atc ctt ggc cgc cgc cca acc gac gcc gag ctg acc gtt tac tcc gtc 259Ile Leu Gly Arg Arg Pro Thr Asp Ala Glu Leu Thr Val Tyr Ser Val

40 45 50atg tgg tcg gag cac tgc tcc tac aag tcc tcc aag gtt cac ctg cgt 307Met Trp Ser Glu His Cys Ser Tyr Lys Ser Ser Lys Val His Leu Arg

55 60 65tac ttc ggt gaa acc acc act gag gaa atg gct tcc aag att ctt gcc 355Tyr Phe Gly Glu Thr Thr Thr Glu Glu Met Ala Ser Lys Ile Leu Ala 70 75 80 85ggc atc ggc gag aac gct ggt gtg gtc gac atc gga gac ggc aac gcc 403Gly Ile Gly Glu Asn Ala Gly Val Val Asp Ile Gly Asp Gly Asn Ala

90 95 100gtg acc ttc cgc gtg gag tcc cac aac cac cca tcc ttc gta gag cca 451Val Thr Phe Arg Val Glu Ser His Asn His Pro Ser Phe Val Glu Pro

105 110 115cac cag ggc gct gcg acc ggc gtc ggc ggc atc gtc cgc gac att atg 499His Gln Gly Ala Ala Thr Gly Val Gly Gly Ile Val Arg Asp Ile Met

120 125 130gct atg ggc gca cgc cca atc gct gtg atg gat cag ctg cgt ttc ggt 547Ala Met Gly Ala Arg Pro Ile Ala Val Met Asp Gln Leu Arg Phe Gly

135 140 145gca ctg gac aac cca gac acc cag cgt gtg ttt cct ggc gtt gtt gac 595Ala Leu Asp Asn Pro Asp Thr Gln Arg Val Phe Pro Gly Val Val Asp150 155 160 165ggc att tcc cat tac ggc aac tgc ctc ggc ctg cca aac atc ggt ggc 643Gly Ile Ser His Tyr Gly Asn Cys Leu Gly Leu Pro Asn Ile Gly Gly

170 175 180gaa acc gtc ttc gac gat tcc tac gca ggt aac cca ctg gtc aac gca 691Glu Thr Val Phe Asp Asp Ser TyrAla Gly Asn Pro Leu Val Asn Ala

185 190 195ctg tgc gtg ggt acc ctc aag gtg gaa gac ctc aag ctt gca ttc gca 739Leu Cys Val Gly Thr Leu Lys Val Glu Asp Leu Lys Leu Ala Phe Ala

200 205 210tcc ggc acc ggc aac aag gtg atc ctg ttc ggt tcc cgc acc ggc ctt 787Ser Gly Thr Gly Asn Lys Val Ile Leu Phe Gly Ser Arg Thr Gly Leu

215 220 225gat ggc atc ggt ggc gtg tcc gtc ctg ggt tcc gca tcc ttc gaa gaa 835Asp Gly Ile Gly Gly Val Ser Val Leu Gly Ser Ala Ser Phe Glu Glu230 235 240 245ggc gaa gag cgc aag ctc cca gct gtt cag gtt ggc gat cct ttc gca 883Gly Glu Glu Arg Lys Leu Pro Ala Val Gln Val Gly Asp Pro Phe Ala

250 255 260gag aag gta ctc atc gag tgc tgc ctc gag ctg tac aag gct ggc gtc 931Glu Lys Val Leu Ile Glu Cys Cys Leu Glu Leu Tyr Lys Ala Gly Val

265 270 275gtg gtc ggt att cag gac ctc ggt ggc ggc gga ctt gcg tgt gca acc 979Val Val Gly Ile Gln Asp Leu Gly Gly Gly Gly Leu Ala Cys Ala Thr

280 285 290tct gag ctg gca gcc gca ggc gac ggc ggc atg cgc gtc aac cta gac 1027Ser Glu Leu Ala Ala Ala Gly Asp Gly Gly Met Arg Val Asn Leu Asp

295 300 305aac gtc cca ctg cgc gca gag aac atg tct gca gct gaa atc ctg gct 1075Asn Val Pro Leu Arg Ala Glu Asn Met Ser Ala Ala Glu Ile Leu Ala310 315 320 325tcc gag tcc cag gag cgc atg tgt gct gtt gtc acc cct gaa aac gtt 1123Ser Glu Ser Gln Glu Arg Met Cys Ala Val Val Thr Pro Glu Asn Val

330335 340gag cgt ttc ctc gag atc tgt gca aag tgg gat gtc acc tgc gca gaa 1171Glu Arg Phe Leu Glu Ile Cys Ala Lys Trp Asp Val Thr Cys Ala Glu

345 350 355atc ggc gaa gtt acc gac gag aag gac cgc tac gtt gtg gtc cac aac 1219Ile Gly Glu Val Thr Asp Glu Lys Asp Arg Tyr Val Val Val His Asn

360 365 370ggt gaa gtt gtt atc gac gca cct cca tca acc atc gat gaa ggc cct 1267Gly Glu Val Val Ile Asp Ala Pro Pro Ser Thr Ile Asp Glu Gly Pro

375 380 385gtc tac aac cgc cca gtt gct cgc cct gag aac cag gac gaa ctg cag 1315Val Tyr Asn Arg Pro Val Ala Arg Pro Glu Asn Gln Asp Glu Leu Gln390 395 400 405ctc gaa ggc gag atc gct cgc cca gtc gac gtt gaa gag atc aag gct 1363Leu Glu Gly Glu Ile Ala Arg Pro Val Asp Val Glu Glu Ile Lys Ala

410 415 420gct tgg ctg aag ctt gtc gct tca cca gca ctt gca tcc cgc gcg ttt 1411Ala Trp Leu Lys Leu Val Ala Ser Pro Ala Leu Ala Ser Arg Ala Phe

425 430 435atc acc gag cag tac gac cgc tac gtc cgc ggc aac acc gtt cag gca 1459Ile Thr Glu Gln Tyr Asp Arg Tyr Val Arg Gly Asn Thr Val Gln Ala

440 445 450aag aac gcc aat gct ggc gtc ttg cgt atc gac gaa gag acc aac cgt 1507Lys Asn Ala Asn Ala Gly Val Leu Arg Ile Asp Glu Glu Thr Asn Arg

455 460 465ggc gtt gcg atc tcc gcc gac gca tcc ggc cgt tac acc aag ctc gag 1555Gly Val Ala Ile Ser Ala Asp Ala Ser Gly Arg Tyr Thr Lys Leu Glu470 475 480 485cca aac act ggc gcg cag ctt gca ctg gct gag gct tac cgc aac gtg 1603ProAsn Thr Gly Ala Gln Leu Ala Leu Ala Glu Ala Tyr Arg Asn Val

490 495 500gtc tcc acc ggt gca cgc cca gtg gct gtc acc aac tgc ctg aac ttc 1651Val Ser Thr Gly Ala Arg Pro Val Ala Val Thr Asn Cys Leu Asn Phe

505 510 515ggt tcc cca gaa aac gct ggt gtt atg tgg cag ttc aag gaa gca gtc 1699Gly Ser Pro Glu Asn Ala Gly Val Met Trp Gln Phe Lys Glu Ala Val

520 525 530cac ggt ctg gca gac gga tcc aag ctt ttg ggc att cca gtg tcc ggc 1747His Gly Leu Ala Asp Gly Ser Lys Leu Leu Gly Ile Pro Val Ser Gly

535 540 545ggt aac gtc tcc ttc tac aac cag act ggt gac gag ccc atc ctg cca 1795Gly Asn Val Ser Phe Tyr Asn Gln Thr Gly Asp Glu Pro Ile Leu Pro550 555 560 565acc cca gtc gtg ggt gtt ttg gga gtc ttg gac aac gtc gag cag agc 1843Thr Pro Val Val Gly Val Leu Gly Val Leu Asp Asn Val Glu Gln Ser

570 575 580atc ggc aac gtc ctc cca tcc gag gac aac gat ctc tac ctc ctg ggt 1891Ile Gly Asn Val Leu Pro Ser Glu Asp Asn Asp Leu Tyr Leu Leu Gly

585 590 595gag acc ttc gat gag ttc ggt ggc tcc atc tgg cag cag gtt tct ggc 1939Glu Thr Phe Asp Glu Phe Gly Gly Ser Ile Trp Gln Gln Val Ser Gly

600 605 610gct ggc ctc aac ggt ctg cca cca gta gtt gac ctg ctc aac gag cag 1987Ala Gly Leu Asn Gly Leu Pro Pro Val Val Asp Leu Leu Asn Glu Gln

615 620 625cgt ctt gca gac ctg ttc gtc ggt tct gat ctg ttt gct gca tcc cac 2035Arg Leu Ala Asp Leu Phe Val Gly Ser Asp Leu Phe Ala Ala Ser His630635 640 645gat ctg tct gag ggc ggc ctt ggc cag acc ctc gca gag ctt gcg atc 2083Asp Leu Ser Glu Gly Gly Leu Gly Gln Thr Leu Ala Glu Leu Ala Ile

650 655 660cac cag aaa aag gga atg gat gtt gat ctc tcc cag atc cac cca tcc 2131His Gln Lys Lys Gly Met Asp Val Asp Leu Ser Gln Ile His Pro Ser

665 670 675ctg ttc acc tca ctg ttt gct gag tcc gct tcc cgc atc gtg gtt gca 2179Leu Phe Thr Ser Leu Phe Ala Glu Ser Ala Ser Arg Ile Val Val Ala

680 685 690acc aac cgc ggc gaa gag ttg gaa aag cgc gca gca gag ctg ggt gtt 2227Thr Asn Arg Gly Glu Glu Leu Glu Lys Arg Ala Ala Glu Leu Gly Val

695 700 705cca gtg ttc aag ctg ggc tgc acc aac gat tca gcc gtc atc gct gtc 2275Pro Val Phe Lys Leu Gly Cys Thr Asn Asp Ser Ala Val Ile Ala Val710 715 720 725aag ggc gca gac gtt gag ttc act gtt tcc gtg gag gaa ctc cgc gaa 2323Lys Gly Ala Asp Val Glu Phe Thr Val Ser Val Glu Glu Leu Arg Glu

730 735 740gca tgg acc aac act ttg cct gag gcc ttc ggt cac gca gtt gga gct 2371Ala Trp Thr Asn Thr Leu Pro Glu Ala Phe Gly His Ala Val Gly Ala

745 750 755aac gca gta gtt gca taattttctg ctgtgaagcc ggg 2409Asn Ala Val Val Ala

760<210>912<211>762<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>912Met Ser Thr Phe Val Asn Asp Thr Val Glu Asp Ala Ile Lys Thr Pro 151015 Glu Leu Asp Gln Pro Phe Glu Ala Leu Gly Leu Lys Asp Asp Glu Tyr

2025 30Ala Arg Ile Lys Glu Ile Leu Gly Arg Arg Pro Thr Asp Ala Glu Leu

35 40 45Thr Val Tyr Ser Val Met Trp Ser Glu His Cys Ser Tyr Lys Ser Ser

50 55 60Lys Val His Leu Arg Tyr Phe Gly Glu Thr Thr Thr Glu Glu Met Ala 65 70 75 80Ser Lys Ile Leu Ala Gly Ile Gly Glu Asn Ala Gly Val Val Asp Ile

85 90 95Gly Asp Gly Asn Ala Val Thr Phe Arg Val Glu Ser His Asn His Pro

100 105 110Ser Phe Val Glu Pro His Gln Gly Ala Ala Thr Gly Val Gly Gly Ile

115 120 125Val Arg Asp Ile Met Ala Met Gly Ala Arg Pro Ile Ala Val Met Asp

130 135 140Gln Leu Arg Phe Gly Ala Leu Asp Asn Pro Asp Thr Gln Arg Val Phe145 150 155 160Pro Gly Val Val Asp Gly Ile Ser His Tyr Gly Asn Cys Leu Gly Leu

165 170 175Pro Asn Ile Gly Gly Glu Thr Val Phe Asp Asp Ser Tyr Ala Gly Asn

180 185 190Pro Leu Val Asn Ala Leu Cys Val Gly Thr Leu Lys Val Glu Asp Leu

195 200 205Lys Leu Ala Phe Ala Ser Gly Thr Gly Asn Lys Val Ile Leu Phe Gly

210 215 220Ser Arg Thr Gly Leu Asp Gly Ile Gly Gly Val Ser Val Leu Gly Ser225 230 235 240Ala Ser Phe Glu Glu Gly Glu Glu Arg Lys Leu Pro Ala Val Gln Val

245 250 255Gly Asp Pro Phe Ala Glu Lys Val Leu Ile Glu Cys Cys Leu Glu Leu

260 265 270Tyr Lys Ala Gly Val Val Val Gly Ile Gln Asp Leu Gly Gly Gly Gly

275 280 285Leu Ala Cys Ala Thr Ser Glu Leu Ala Ala Ala Gly Asp Gly Gly Met

290 295 300Arg Val Asn Leu Asp Asn Val Pro Leu Arg Ala Glu Asn Met Ser Ala305 310 315 320Ala Glu Ile Leu Ala Ser Glu Ser Gln Glu Arg Met Cys Ala Val Val

325 330 335Thr Pro Glu Asn Val Glu Arg Phe Leu Glu Ile Cys Ala Lys Trp Asp

340 345 350Val Thr Cys Ala Glu Ile Gly Glu Val Thr Asp Glu Lys Asp Arg Tyr

355 360 365Val Val Val His Asn Gly Glu Val Val Ile Asp Ala Pro Pro Ser Thr

370 375 380Ile Asp Glu Gly Pro Val Tyr Asn Arg Pro Val Ala Arg Pro Glu Asn385 390 395 400Gln Asp Glu Leu Gln Leu Glu Gly Glu Ile Ala Arg Pro Val Asp Val

405 410 415Glu Glu Ile Lys Ala Ala Trp Leu Lys Leu Val Ala Ser Pro Ala Leu

420 425 430Ala Ser Arg Ala Phe Ile Thr Glu Gln Tyr Asp Arg Tyr Val Arg Gly

435 440 445Asn Thr Val Gln Ala Lys Asn Ala Asn Ala Gly Val Leu Arg Ile Asp

450 455 460Glu Glu Thr Asn Arg Gly Val Ala Ile Ser Ala Asp Ala Ser Gly Arg465470 475 480Tyr Thr Lys Leu Glu Pro Asn Thr Gly Ala Gln Leu Ala Leu Ala Glu

485 490 495Ala Tyr Arg Asn Val Val Ser Thr Gly Ala Arg Pro Val Ala Val Thr

500 505 510Asn Cys Leu Asn Phe Gly Ser Pro Glu Asn Ala Gly Val Met Trp Gln

515 520 525Phe Lys Glu Ala Val His Gly Leu Ala Asp Gly Ser Lys Leu Leu Gly

530 535 540Ile Pro Val Ser Gly Gly Asn Val Ser Phe Tyr Asn Gln Thr Gly Asp545 550 555 560Glu Pro Ile Leu Pro Thr Pro Val Val Gly Val Leu Gly Val Leu Asp

565 570 575Asn Val Glu Gln Ser Ile Gly Asn Val Leu Pro Ser Glu Asp Asn Asp

580 585 590Leu Tyr Leu Leu Gly Glu Thr Phe Asp Glu Phe Gly Gly Ser Ile Trp

595 600 605Gln Gln Val Ser Gly Ala Gly Leu Asn Gly Leu Pro Pro Val Val Asp

610 615 620Leu Leu Asn Glu Gln Arg Leu Ala Asp Leu Phe Val Gly Ser Asp Leu625 630 635 640Phe Ala Ala Ser His Asp Leu Ser Glu Gly Gly Leu Gly Gln Thr Leu

645 650 655Ala Glu Leu Ala Ile His Gln Lys Lys Gly Met Asp Val Asp Leu Ser

660 665 670Gln Ile His Pro Ser Leu Phe Thr Ser Leu Phe Ala Glu Ser Ala Ser

675 680 685Arg Ile Val Val Ala Thr Asn Arg Gly Glu Glu Leu Glu Lys Arg Ala

690 695 700Ala Glu Leu Gly Val Pro Val Phe Lys Leu Gly Cys Thr Asn Asp Ser705 710 715 720Ala Val Ile Ala Val Lys Gly Ala Asp Val Glu Phe Thr Val Ser Val

725 730 735Glu Glu Leu Arg Glu Ala Trp Thr Asn Thr Leu Pro Glu Ala Phe Gly

740 745 750His Ala Val Gly Ala Asn Ala Val Val Ala

755760<210>913<211>638<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(54). (638)<223>FRXA02805<400>913tgtgatggat cagctgcgtt tcgggtgcac tggacaaccc agacacccag cgt gtg ttt 59

Val Phecct ggc gtt gtt gac ggc att tcc cat tac ggc aac tgc ctc ggc ctg 107Pro Gly Val Val Asp Gly Ile Ser His Tyr Gly Asn Cys Leu Gly Leu

5 10 15cca aac atc ggt ggc gaa acc gtc ttc gac gat tcc tac gca ggt aac 155Pro Asn Ile Gly Gly Glu Thr Val Phe Asp Asp Ser Tyr Ala Gly Asn

20 25 30cca ctg gtc aac gca ctg tgc gtg ggt acc ctc aag gtg gaa gac ctc 203Pro Leu Val Asn Ala Leu Cys Val Gly Thr Leu Lys Val Glu Asp Leu 35 40 45 50aag ctt gca ttc gca tcc ggc acc ggc aac aag gtg atc ctg ttc ggt 251Lys Leu Ala Phe Ala Ser Gly Thr Gly Asn Lys Val Ile Leu Phe Gly

55 60 65tcc cgc acc ggc ctt gat ggc atc ggt ggc gtg tcc gtc ctg ggt tcc 299Ser Arg Thr Gly Leu Asp Gly Ile Gly Gly Val Ser Val Leu Gly Ser

70 7580gca tcc ttc gaa gaa ggc gaa gag cgc aag ctc cca gct gtt cag gtt 347Ala Ser Phe Glu Glu Gly Glu Glu Arg Lys Leu Pro Ala Val Gln Val

85 90 95ggc gat cct ttc gca gag aag gta ctc atc gag tgc tgc ctc gag ctg 395Gly Asp Pro Phe Ala Glu Lys Val Leu Ile Glu Cys Cys Leu Glu Leu

100 105 110tac aag gct ggc gtc gtg gtc ggt att cag gac ctc ggt ggc ggc gga 443Tyr Lys Ala Gly Val Val Val Gly Ile Gln Asp Leu Gly Gly Gly Gly115 120 125 130ctt gcg tgt gca acc tct gag ctg gca gcc gca ggc gac ggc ggc atg 491Leu Ala Cys Ala Thr Ser Glu Leu Ala Ala Ala Gly Asp Gly Gly Met

135 140 145cgc gtc aac cta gac aac gtc cca ctg cgc gca gag aac atg tct gca 539Arg Val Asn Leu Asp Asn Val Pro Leu Arg Ala Glu Asn Met Ser Ala

150 155 160gct gaa atc ctg gct tcc gag tcc cag gag cgc atg tgt gct gtt gtc 587Ala Glu Ile Leu Ala Ser Glu Ser Gln Glu Arg Met Cys Ala Val Val

165 170 175acc cct gaa aac gtt gag cgt ttc ctc gag atc tgt gca aag tgg gat 635Thr Pro Glu Asn Val Glu Arg Phe Leu Glu Ile Cys Ala Lys Trp Asp

180185190 gtc 638Val195<210>914<211>195<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>914Val Phe Pro Gly Val Val Asp Gly Ile Ser His Tyr Gly Asn Cys Leu 151015 Gly Leu Pro Asn Ile Gly Gly Glu Thr Val Phe Asp Asp Ser Tyr Ala

20 25 30Gly Asn Pro Leu Val Asn Ala Leu Cys Val Gly Thr Leu Lys Val Glu

35 40 45Asp Leu Lys Leu Ala Phe Ala Ser Gly Thr Gly Asn Lys Val Ile Leu

50 55 60Phe Gly Ser Arg Thr Gly Leu Asp Gly Ile Gly Gly Val Ser Val Leu 65 70 75 80Gly Ser Ala Ser Phe Glu Glu Gly Glu Glu Arg Lys Leu Pro Ala Val

85 90 95Gln Val Gly Asp Pro Phe Ala Glu Lys Val Leu Ile Glu Cys Cys Leu

100 105 110Glu Leu Tyr Lys Ala Gly Val Val Val Gly Ile Gln Asp Leu Gly Gly

115 120 125Gly Gly Leu Ala Cys Ala Thr Ser Glu Leu Ala Ala Ala Gly Asp Gly

130 135 140Gly Met Arg Val Asn Leu Asp Asn Val Pro Leu Arg Ala Glu Asn Met145 150 155 160Ser Ala Ala Glu Ile Leu Ala Ser Glu Ser Gln Glu Arg Met Cys Ala

165 170 175Val Val Thr Pro Glu Asn Val Glu Arg Phe Leu Glu Ile Cys Ala Lys

180 185 190Trp Asp Val

195<210>915<211>697<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(23). (697)<223>FRXA00537<220><221>misc _ feature<222>120<223>n ═ a, c, t, or g<220><221>VARIANT<222>33<223>Xaa ═ Ile, Thr, Asn, or Ser<400>915caacagcact tgcatcccgc gc gtg tat cac cga gca gta ctg aac gct acg 52

Val Tyr His Arg Ala Val Leu Asn Ala Thr

1 5 10tcc gcg gca aca ccg ttc aag caa aag aac gcc aat gct ggc gtc ttg 100Ser Ala Ala Thr Pro Phe Lys Gln Lys Asn Ala Asn Ala Gly Val Leu

15 20 25cgt atc gac gaa gag acc anc cgt ggc gtt gcg atc tcc gcc gac gca 148Arg Ile Asp Glu Glu Thr Xaa Arg Gly Val Ala Ile Ser Ala Asp Ala

30 35 40tcc ggc cgt tac acc aag ctc gag cca aac act ggc gcg cag ctt gca 196Ser Gly Arg Tyr Thr Lys Leu Glu Pro Asn Thr Gly Ala Gln Leu Ala

45 50 55ctg gct gag gct tac cgc aac gtg gtc tcc acc ggt gca cgc cca gtg 244Leu Ala Glu Ala Tyr Arg Asn Val Val Ser Thr Gly Ala Arg Pro Val

60 65 70gct gtc acc aac tgc ctg aac ttc ggt tcc cca gaa aac gct ggt gtt 292Ala Val Thr Asn Cys Leu Asn Phe Gly Ser Pro Glu Asn Ala Gly Val 75 80 85 90atg tgg cag ttc aag gaa gca gtc cac ggt ctg gca gac gga tcc aag 340Met Trp Gln Phe Lys Glu Ala Val His Gly Leu Ala Asp Gly Ser Lys

95 100 105ctt ttg ggc att cca gtg tcc ggc ggt aac gtc tcc ttc tac aac cag 388Leu Leu Gly Ile Pro Val Ser Gly Gly Asn Val Ser Phe Tyr Asn Gln

110 115 120act ggt gac gag ccc atc ctg cca acc cca gtc gtg ggt gtt ttg gga 436Thr Gly Asp Glu Pro Ile Leu Pro Thr Pro Val Val Gly Val Leu Gly

125 130 135gtc ttg gac aac gtc gag cag agc atc ggc aac gtc ctc cca tcc gag 484Val Leu Asp Asn Val Glu Gln Ser Ile Gly Asn Val Leu Pro Ser Glu

140 145 150gac aac gat ctc tac ctc ctg ggt gag acc ttc gat gag ttc ggt ggc 532Asp Asn Asp Leu Tyr Leu Leu Gly Glu Thr Phe Asp GluPhe Gly Gly155 160 165 170tcc atc tgg cag cag gtt tct ggc gct ggc ctc aac ggt ctg cca cca 580Ser Ile Trp Gln Gln Val Ser Gly Ala Gly Leu Asn Gly Leu Pro Pro

175 180 185gta gtt gac ctg ctc aac gag cag cgt ctt gca gac ctg ttc gtc ggt 628Val Val Asp Leu Leu Asn Glu Gln Arg Leu Ala Asp Leu Phe Val Gly

190 195 200tct gat ctg ttt gct gca tcc cac gat ctg tct gag ggc ggc ctt ggc 676Ser Asp Leu Phe Ala Ala Ser His Asp Leu Ser Glu Gly Gly Leu Gly

205 210 215cag acc ctc gca gag ctt gcg 697Gln Thr Leu Ala Glu Leu Ala

220225<210>916<211>225<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>VARIANT<222>33<223>Xaa ═ Ile, Thr, Asn, or Ser<400>916Val Tyr His Arg Ala Val Leu Asn Ala Thr Ser Ala Ala Thr Pro Phe 151015 Lys Gln Lys Asn Ala Asn Ala Gly Val Leu Arg Ile Asp Glu Glu Thr

20 25 30Xaa Arg Gly Val Ala Ile Ser Ala Asp Ala Ser Gly Arg Tyr Thr Lys

35 40 45Leu Glu Pro Asn Thr Gly Ala Gln Leu Ala Leu Ala Glu Ala Tyr Arg

50 55 60Asn Val Val Ser Thr Gly Ala Arg Pro Val Ala Val Thr Asn Cys Leu 65 70 75 80Asn Phe Gly Ser Pro Glu Asn Ala Gly Val Met Trp Gln Phe Lys Glu

85 90 95Ala Val His Gly Leu Ala Asp Gly Ser Lys Leu Leu Gly Ile Pro Val

100105 110Ser Gly Gly Asn Val Ser Phe Tyr Asn Gln Thr Gly Asp Glu Pro Ile

115 120 125Leu Pro Thr Pro Val Val Gly Val Leu Gly Val Leu Asp Asn Val Glu

130 135 140Gln Ser Ile Gly Asn Val Leu Pro Ser Glu Asp Asn Asp Leu Tyr Leu145 150 155 160Leu Gly Glu Thr Phe Asp Glu Phe Gly Gly Ser Ile Trp Gln Gln Val

165 170 175Ser Gly Ala Gly Leu Asn Gly Leu Pro Pro Val Val Asp Leu Leu Asn

180 185 190Glu Gln Arg Leu Ala Asp Leu Phe Val Gly Ser Asp Leu Phe Ala Ala

195 200 205Ser His Asp Leu Ser Glu Gly Gly Leu Gly Gln Thr Leu Ala Glu Leu

210215220 Ala225<210>917<211>302<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (279)<223>FRXA00561<400>917ctc ttc cca gat cca ccc atc cct gtt cac ctc act tgt ttg ctg agt 48Leu Phe Pro Asp Pro Pro Ile Pro Val His Leu Thr Cys Leu Leu Ser 151015 ccc gct tcc cgc atc gtg gtt gca acc aac cgc ggc gaa gag ttg gaa 96Pro Ala Ser Arg Ile Val Val Ala Thr Asn Arg Gly Glu Glu Leu Glu

20 25 30aag cgc gca gca gag ctg ggt gtt cca gtg ttc aag ctg ggc tgc acc 144Lys Arg Ala Ala Glu Leu Gly Val Pro Val Phe Lys Leu Gly Cys Thr

35 40 45aac gat tca gcc gtc atc gct gtc aag ggc gca gac gtt gag ttc act 192Asn Asp Ser Ala Val Ile Ala Val Lys Gly Ala Asp Val Glu Phe Thr

50 5560gtt tcc gtg gag gaa ctc cgc gaa gca tgg acc aac act ttg cct gag 240Val Ser Val Glu Glu Leu Arg Glu Ala Trp Thr Asn Thr Leu Pro Glu65 70 75 80gcc ttc ggt cac gca gtt gga gct aac gca gta gtt gca taattttctg 289Ala Phe Gly His Ala Val Gly Ala Asn Ala Val Val Ala

8590 ctgtgaagcc ggg 302<210>918<211>93<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>918Leu Phe Pro Asp Pro Pro Ile Pro Val His Leu Thr Cys Leu Leu Ser 151015 Pro Ala Ser Arg Ile Val Val Ala Thr Asn Arg Gly Glu Glu Leu Glu

20 25 30Lys Arg Ala Ala Glu Leu Gly Val Pro Val Phe Lys Leu Gly Cys Thr

35 40 45Asn Asp Ser Ala Val Ile Ala Val Lys Gly Ala Asp Val Glu Phe Thr

50 55 60Val Ser Val Glu Glu Leu Arg Glu Ala Trp Thr Asn Thr Leu Pro Glu 65 70 75 80Ala Phe Gly His Ala Val Gly Ala Asn Ala Val Val Ala

8590<210>919<211>792<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (769)<223>RXA00541<400>919atgattccgt caccgaagct gacctaaaga aaattgctga aaccctcctc gcaaacaccg 60tcatcgaaga cttcgatgtg gtgggagttg aggtcgcgaa gtg agc gcc aaa atc 115

Val Ser Ala Lys Ile

1 5ggt gtc att acc ttc cca ggc acc ctt gac gat gta gat gca gca cgc 163Gly Val Ile Thr Phe Pro Gly Thr Leu Asp Asp Val Asp Ala Ala Arg

10 15 20gct gct cgc atc gca ggt gcagaa gta atc agc ctg tgg cac gct gac 211Ala Ala Arg Ile Ala Gly Ala Glu Val Ile Ser Leu Trp His Ala Asp

25 30 35gag gat ctc aag ggc gtc gac gca gtt gtc gtt ccc ggt gga ttc tcc 259Glu Asp Leu Lys Gly Val Asp Ala Val Val Val Pro Gly Gly Phe Ser

40 45 50tac ggc gat tac ctg cgc acc ggt gca atc tct gca ctg gcg cca gta 307Tyr Gly Asp Tyr Leu Arg Thr Gly Ala Ile Ser Ala Leu Ala Pro Val

55 60 65atg cag tcc gtg att gag cag gcc ggt aag ggt atg cca gtc ttg ggc 355Met Gln Ser Val Ile Glu Gln Ala Gly Lys Gly Met Pro Val Leu Gly 70 75 80 85att tgc aac ggc ttc cag atc ctc acc gaa gca cgc ctg ctt cca ggc 403Ile Cys Asn Gly Phe Gln Ile Leu Thr Glu Ala Arg Leu Leu Pro Gly

90 95 100gcg ctg acc cgc aac aag ggt ctg cac ttt cac tgt gta gac gca cac 451Ala Leu Thr Arg Asn Lys Gly Leu His Phe His Cys Val Asp Ala His

105 110 115ctc gtt gta gag aac aac acc act gca tgg acc aac act ttg gaa aag 499Leu Val Val Glu Asn Asn Thr Thr Ala Trp Thr Asn Thr Leu Glu Lys

120 125 130ggt cag cag atc ctt att cct gca aag cac ggt gaa ggt cgc ttc cag 547Gly Gln Gln Ile Leu Ile Pro Ala Lys His Gly Glu Gly Arg Phe Gln

135 140 145gca gac gca gag acc atc gcc cag ctt gag ggt gaa ggc cgc gtg gtg 595Ala Asp Ala Glu Thr Ile Ala Gln Leu Glu Gly Glu Gly Arg Val Val150 155 160 165ttc cgt tac acc gat aac ttc aac ggt tcc gtc aac gat atc gcc ggt 643Phe Arg Tyr Thr Asp Asn Phe Asn Gly Ser Val Asn Asp Ile Ala Gly

170 175 180atc act aat gaa act ggt cgc atc gtc ggt ctc atg ccg cac ccg gaa 691Ile Thr Asn Glu Thr Gly Arg Ile Val Gly Leu Met Pro His Pro Glu

185 190 195cat gcc gtc gaa aag cta acc ggc cca tct att gat ggc ctg gag ctg 739His Ala Val Glu Lys Leu Thr Gly Pro Ser Ile Asp Gly Leu Glu Leu

200 205 210ttc ctg tcc gcc gtt ggc acc atc gcg gct taagaggagt aaatatgagc 789Phe Leu Ser Ala Val Gly Thr Ile Ala Ala

215220 act 792<210>920<211>223<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>920Val Ser Ala Lys Ile Gly Val Ile Thr Phe Pro Gly Thr Leu Asp Asp 151015 Val Asp Ala Ala Arg Ala Ala Arg Ile Ala Gly Ala Glu Val Ile Ser

20 25 30Leu Trp His Ala Asp Glu Asp Leu Lys Gly Val Asp Ala Val Val Val

35 40 45Pro Gly Gly Phe Ser Tyr Gly Asp Tyr Leu Arg Thr Gly Ala Ile Ser

50 55 60Ala Leu Ala Pro Val Met Gln Ser Val Ile Glu Gln Ala Gly Lys Gly 65 70 75 80Met Pro Val Leu Gly Ile Cys Asn Gly Phe Gln Ile Leu Thr Glu Ala

85 90 95Arg Leu Leu Pro Gly Ala Leu Thr Arg Asn Lys Gly Leu His Phe His

100 105 110Cys Val Asp Ala His Leu Val Val Glu Asn Asn Thr Thr Ala Trp Thr

115 120 125Asn Thr Leu Glu Lys Gly Gln Gln Ile Leu Ile Pro Ala Lys His Gly

130135 140Glu Gly Arg Phe Gln Ala Asp Ala Glu Thr Ile Ala Gln Leu Glu Gly145 150 155 160Glu Gly Arg Val Val Phe Arg Tyr Thr Asp Asn Phe Asn Gly Ser Val

165 170 175Asn Asp Ile Ala Gly Ile Thr Asn Glu Thr Gly Arg Ile Val Gly Leu

180 185 190Met Pro His Pro Glu His Ala Val Glu Lys Leu Thr Gly Pro Ser Ile

195 200 205Asp Gly Leu Glu Leu Phe Leu Ser Ala Val Gly Thr Ile Ala Ala

210215220<210>921<211>1014<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (991)<223>RXA00620<400>921ggtgatccat gtcaggaagc cagcggtgaa accggcagtg aaaccagcgg tgaatgctaa 60aattttccga acacacccga ggggtctaga cttgcctaac atg cgt cct gaa ctc 115

Met Arg Pro Glu Leu

1 5tcc cag tac aag cac ctg tcg gca ggc aag gtc cgt gag atc tac gag 163Ser Gln Tyr Lys His Leu Ser Ala Gly Lys Val Arg Glu Ile Tyr Glu

10 15 20atc gac gac aag cac atc ctc atg gtg gct tcc gat cgt atc tct gca 211Ile Asp Asp Lys His Ile Leu Met Val Ala Ser Asp Arg Ile Ser Ala

25 30 35tac gat ttc atc ctc gat acc gaa att cca gac aag ggt cga gtg ctc 259Tyr Asp Phe Ile Leu Asp Thr Glu Ile Pro Asp Lys Gly Arg Val Leu

40 45 50act gcg atg agc cag ttc ttc ttc gac acc atc gat ttt cct aat cac 307Thr Ala Met Ser Gln Phe Phe Phe AspThr Ile Asp Phe Pro Asn His

55 60 65ctt gca ggt ccc gct gat gat cca cgt atc cca gaa gaa gtt ttg gga 355Leu Ala Gly Pro Ala Asp Asp Pro Arg Ile Pro Glu Glu Val Leu Gly 70 75 80 85cga gca atg gtg tgc aag aag ctc aac atg ctt cct ttt gaa tgc gtg 403Arg Ala Met Val Cys Lys Lys Leu Asn Met Leu Pro Phe Glu Cys Val

90 95 100gtt cgt gga tac ctc act ggc tct gga ctt gtt gaa tac aag cag acc 451Val Arg Gly Tyr Leu Thr Gly Ser Gly Leu Val Glu Tyr Lys Gln Thr

105 110 115agc tcc gtg tgt gga gtt gag ctc cca gaa ggc ctc gtt gaa tct tct 499Ser Ser Val Cys Gly Val Glu Leu Pro Glu Gly Leu Val Glu Ser Ser

120 125 130cag ctg cct gag cca atc ttt acc cca gcc acc aag gct gac atc ggc 547Gln Leu Pro Glu Pro Ile Phe Thr Pro Ala Thr Lys Ala Asp Ile Gly

135 140 145gac cac gac atc aat gtc tcc ttt gac gtt gtt gaa gaa cgt ctc ggc 595Asp His Asp Ile Asn Val Ser Phe Asp Val Val Glu Glu Arg Leu Gly150 155 160 165gaa gct cgt gcg aac cag ttg cgc gat gcc tct att gct att tac aag 643Glu Ala Arg Ala Asn Gln Leu Arg Asp Ala Ser Ile Ala Ile Tyr Lys

170 175 180gct gct gct gag atc gcc cgt gac cgt ggc gtc atc ctt gcc gac acc 691Ala Ala Ala Glu Ile Ala Arg Asp Arg Gly Val Ile Leu Ala Asp Thr

185 190 195aaa ttt gag ttc ggc atc gat gaa gat ggc acc ctc gtg ctt ggt gat 739Lys Phe Glu Phe Gly Ile Asp Glu Asp Gly Thr Leu Val Leu Gly Asp

200 205210gaa gtc ctt acc cca gat tcc tcc cgc tac tgg cct ttg gaa ggc tat 787Glu Val Leu Thr Pro Asp Ser Ser Arg Tyr Trp Pro Leu Glu Gly Tyr

215 220 225gaa gca gga tct gtg caa cca agc ttt gat aag caa ttc gtg cgc aac 835Glu Ala Gly Ser Val Gln Pro Ser Phe Asp Lys Gln Phe Val Arg Asn230 235 240 245tgg ctc acc ggc cct aaa tct ggc tgg gac aag gat tcc ggc ttg gag 883Trp Leu Thr Gly Pro Lys Ser Gly Trp Asp Lys Asp Ser Gly Leu Glu

250 255 260cca cca gct ctg cca ggt tcc gtt gtt gag gca acc cgc gag cgc tac 931Pro Pro Ala Leu Pro Gly Ser Val Val Glu Ala Thr Arg Glu Arg Tyr

265 270 275atc gag gcc tac gag ctg att tct ggt cag aag ttc tgc cag tgg att 979Ile Glu Ala Tyr Glu Leu Ile Ser Gly Gln Lys Phe Cys Gln Trp Ile

280 285 290ggt tct tgc gtc taagctgctt gattttccct aaa 1014Gly Ser Cys Val

295<210>922<211>297<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>922Met Arg Pro Glu Leu Ser Gln Tyr Lys His Leu Ser Ala Gly Lys Val 151015 Arg Glu Ile Tyr Glu Ile Asp Asp Lys His Ile Leu Met Val Ala Ser

20 25 30Asp Arg Ile Ser Ala Tyr Asp Phe Ile Leu Asp Thr Glu Ile Pro Asp

35 40 45Lys Gly Arg Val Leu Thr Ala Met Ser Gln Phe Phe Phe Asp Thr Ile

50 55 60Asp Phe Pro Asn His Leu Ala Gly Pro Ala Asp Asp Pro Arg Ile Pro 65 70 75 80Glu Glu Val Leu Gly Arg Ala Met Val Cys Lys Lys Leu Asn Met Leu

85 90 95Pro Phe Glu Cys Val Val Arg Gly Tyr Leu Thr Gly Ser Gly Leu Val

100 105 110Glu Tyr Lys Gln Thr Ser Ser Val Cys Gly Val Glu Leu Pro Glu Gly

115 120 125Leu Val Glu Ser Ser Gln Leu Pro Glu Pro Ile Phe Thr Pro Ala Thr

130 135 140Lys Ala Asp Ile Gly Asp His Asp Ile Asn Val Ser Phe Asp Val Val145 150 155 160Glu Glu Arg Leu Gly Glu Ala Arg Ala Asn Gln Leu Arg Asp Ala Ser

165 170 175Ile Ala Ile Tyr Lys Ala Ala Ala Glu Ile Ala Arg Asp Arg Gly Val

180 185 190Ile Leu Ala Asp Thr Lys Phe Glu Phe Gly Ile Asp Glu Asp Gly Thr

195 200 205Leu Val Leu Gly Asp Glu Val Leu Thr Pro Asp Ser Ser Arg Tyr Trp

210 215 220Pro Leu Glu Gly Tyr Glu Ala Gly Ser Val Gln Pro Ser Phe Asp Lys225 230 235 240Gln Phe Val Arg Asn Trp Leu Thr Gly Pro Lys Ser Gly Trp Asp Lys

245 250 255Asp Ser Gly Leu Glu Pro Pro Ala Leu Pro Gly Ser Val Val Glu Ala

260 265 270Thr Arg Glu Arg Tyr Ile Glu Ala Tyr Glu Leu Ile Ser Gly Gln Lys

275 280 285Phe Cys Gln Trp Ile Gly Ser Cys Val

290295<210>923<211>1293<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1270)<223>RXN00770<400>923ccatgggtct gccacaggga aacagcaacg cagacctagt ccgcaagatg caagcaaccg 60cctcaagtta agatcggtag gcgatagggg ttgagcattt ttg ctc tcc ccg tat 115

Leu Leu Ser Pro Tyr

1 5gcg tgg ggg ttg tcc cgc gca ctt tta gac agt tat gtt cct aat aag 163Ala Trp Gly Leu Ser Arg Ala Leu Leu Asp Ser Tyr Val Pro Asn Lys

10 15 20ttc caa acc cca gca gga gaa gcg aag tac acg atg agt gat cac cag 211Phe Gln Thr Pro Ala Gly Glu Ala Lys Tyr Thr Met Ser Asp His Gln

25 30 35gac acc acc gcc gaa ggc gtt tca tac gca gca gca gga gtc gac atc 259Asp Thr Thr Ala Glu Gly Val Ser Tyr Ala Ala Ala Gly Val Asp Ile

40 45 50gaa gcc ggc gat cgt gcc gtc gaa ctc ttt gca cca atg gcc aag cgc 307Glu Ala Gly Asp Arg Ala Val Glu Leu Phe Ala Pro Met Ala Lys Arg

55 60 65gcc acc cgc cca gag gtt ctt ggc aac ctc gga ggc ttc gca gga ctc 355Ala Thr Arg Pro Glu Val Leu Gly Asn Leu Gly Gly Phe Ala Gly Leu 70 75 80 85ttt gag ctc gga aaa tac aag aag cca atc ctc gca gca gga tct gac 403Phe Glu Leu Gly Lys Tyr Lys Lys Pro Ile Leu Ala Ala Gly Ser Asp

90 95 100gga gtc ggc acc aag ctt gtc atc gcc cag atg atg gac aag cac gac 451Gly Val Gly Thr Lys Leu Val Ile Ala Gln Met Met Asp Lys His Asp

105 110 115acc atc ggc atc gac ctt gtt gca atg tgt gtg gat gacctc gtt gtc 499Thr Ile Gly Ile Asp Leu Val Ala Met Cys Val Asp Asp Leu Val Val

120 125 130acc ggc gca gag cca ctg ttc ctc cag gac tac atc gcc atc ggc aag 547Thr Gly Ala Glu Pro Leu Phe Leu Gln Asp Tyr Ile Ala Ile Gly Lys

135 140 145gtt gtc cca gag cac gtt gct gag atc gtc tcc ggt atc gca gaa ggc 595Val Val Pro Glu His Val Ala Glu Ile Val Ser Gly Ile Ala Glu Gly150 155 160 165tgt gtc cag gca ggc tgt gct ctg ctc ggt ggc gaa acc gca gaa cac 643Cys Val Gln Ala Gly Cys Ala Leu Leu Gly Gly Glu Thr Ala Glu His

170 175 180cca ggt gtt atg gaa cca gac cac tac gat gtc tcc gca act gca gtc 691Pro Gly Val Met Glu Pro Asp His Tyr Asp Val Ser Ala Thr Ala Val

185 190 195ggc gtt gtc gaa gca gat gaa ctg cta gga cca gac cgc gtc cgc gca 739Gly Val Val Glu Ala Asp Glu Leu Leu Gly Pro Asp Arg Val Arg Ala

200 205 210ggc gac gtc ctc atc ggc atg gct tcc tcc ggt ctg cac tcc aac ggt 787Gly Asp Val Leu Ile Gly Met Ala Ser Ser Gly Leu His Ser Asn Gly

215 220 225tac tcc ctg gct cgc cac gtc ctc ctg gaa aag gca ggc ctg gcg ctt 835Tyr Ser Leu Ala Arg His Val Leu Leu Glu Lys Ala Gly Leu Ala Leu230 235 240 245gac gga cac atc gaa gaa ctc gga cgc acc ctc ggt gaa gaa ctt ctc 883Asp Gly His Ile Glu Glu Leu Gly Arg Thr Leu Gly Glu Glu Leu Leu

250 255 260gag cca acc cgc atc tac gcc aag gac tgc ctg gca ctg atc gca gag 931Glu Pro Thr Arg Ile Tyr Ala Lys Asp Cys Leu Ala Leu Ile Ala Glu

265 270 275tgc gaa gtt cac acc ttc tgc cac gtc acc ggc ggc ggc ctc gca ggc 979Cys Glu Val His Thr Phe Cys His Val Thr Gly Gly Gly Leu Ala Gly

280 285 290aac ctc gag cgg gtt gtc cca gaa ggg ctc gtc gca gaa atg tcc cga 1027Asn Leu Glu Arg Val Val Pro Glu Gly Leu Val Ala Glu Met Ser Arg

295 300 305gca act tgg acc cca ggc caa atc ttc cgc acc atc tcc tct gtg ggc 1075Ala Thr Trp Thr Pro Gly Gln Ile Phe Arg Thr Ile Ser Ser Val Gly310 315 320 325aag gtt tcc cgc gaa gaa atg gaa aag acc ttc aac atg ggt gtc ggc 1123Lys Val Ser Arg Glu Glu Met Glu Lys Thr Phe Asn Met Gly Val Gly

330 335 340atg gtt gca gtc gtt gct gaa aag gac cgc gac cgc gcc ctg gca atg 1171Met Val Ala Val Val Ala Glu Lys Asp Arg Asp Arg Ala Leu Ala Met

345 350 355ctc acc gca cgt cac att gac tgc tgg gaa atc gga acc gta cgc aac 1219Leu Thr Ala Arg His Ile Asp Cys Trp Glu Ile Gly Thr Val Arg Asn

360 365 370ggt gaa gag gga gag cct cgc gtg atc ctc aac ggc gag cac cct ggc 1267Gly Glu Glu Gly Glu Pro Arg Val Ile Leu Asn Gly Glu His Pro Gly

375380385 tac taagcccaac tgtctgctct aag 1293Tyr390<210>924<211>390<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>924Leu Leu Ser Pro Tyr Ala Trp Gly Leu Ser Arg Ala Leu Leu Asp Ser 151015 Tyr Val Pro Asn Lys Phe Gln Thr Pro Ala Gly Glu Ala Lys Tyr Thr

20 25 30Met Ser Asp His Gln Asp Thr Thr Ala Glu Gly Val Ser Tyr Ala Ala

35 40 45Ala Gly Val Asp Ile Glu Ala Gly Asp Arg Ala Val Glu Leu Phe Ala

50 55 60Pro Met Ala Lys Arg Ala Thr Arg Pro Glu Val Leu Gly Asn Leu Gly 65 70 75 80Gly Phe Ala Gly Leu Phe Glu Leu Gly Lys Tyr Lys Lys Pro Ile Leu

85 90 95Ala Ala Gly Ser Asp Gly Val Gly Thr Lys Leu Val Ile Ala Gln Met

100 105 110Met Asp Lys His Asp Thr Ile Gly Ile Asp Leu Val Ala Met Cys Val

115 120 125Asp Asp Leu Val Val Thr Gly Ala Glu Pro Leu Phe Leu Gln Asp Tyr

130 135 140Ile Ala Ile Gly Lys Val Val Pro Glu His Val Ala Glu Ile Val Ser145 150 155 160Gly Ile Ala Glu Gly Cys Val Gln Ala Gly Cys Ala Leu Leu Gly Gly

165 170 175Glu Thr Ala Glu His Pro Gly Val Met Glu Pro Asp His Tyr Asp Val

180 185 190Ser Ala Thr Ala Val Gly Val Val Glu Ala Asp Glu Leu Leu Gly Pro

195 200 205Asp Arg Val Arg Ala Gly Asp Val Leu Ile Gly Met Ala Ser Ser Gly

210 215 220Leu His Ser Asn Gly Tyr Ser Leu Ala Arg His Val Leu Leu Glu Lys225 230 235 240Ala Gly Leu Ala Leu Asp Gly His Ile Glu Glu Leu Gly Arg Thr Leu

245 250 255Gly Glu Glu Leu Leu Glu Pro Thr Arg Ile Tyr Ala Lys Asp Cys Leu

260 265 270Ala Leu Ile Ala Glu Cys Glu Val His Thr Phe Cys His Val Thr Gly

275 280 285Gly Gly Leu Ala Gly Asn Leu Glu Arg Val Val Pro Glu Gly Leu Val

290 295 300Ala Glu Met Ser Arg Ala Thr Trp Thr Pro Gly Gln Ile Phe Arg Thr305 310 315 320Ile Ser Ser Val Gly Lys Val Ser Arg Glu Glu Met Glu Lys Thr Phe

325 330 335Asn Met Gly Val Gly Met Val Ala Val Val Ala Glu Lys Asp Arg Asp

340 345 350Arg Ala Leu Ala Met Leu Thr Ala Arg His Ile Asp Cys Trp Glu Ile

355 360 365Gly Thr Val Arg Asn Gly Glu Glu Gly Glu Pro Arg Val Ile Leu Asn

370375380 Gly Glu His Pro Gly Tyr 385390<210>925<211>818<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(15) } (818)<223>FRXA00557<400>925tgggttgagc attt ttg ctc tcc ccg tat gcg tgg ggg ttg tcc cgc gca 50

Leu Leu Ser Pro Tyr Ala Trp Gly Leu Ser Arg Ala

1 5 10ctt tta gac agt tat gtt cct aat aag ttc caa acc cca gca gga gaa 98Leu Leu Asp Ser Tyr Val Pro Asn Lys Phe Gln Thr Pro Ala Gly Glu

15 20 25gcg aag tac acg atg agt gat cac cag gac acc acc gcc gaa ggc gtt 146Ala Lys Tyr Thr Met Ser Asp His Gln Asp Thr Thr Ala Glu Gly Val

30 35 40tca tac gca gca gca gga gtc gac atc gaa gcc ggc gat cgt gcc gtc 194Ser Tyr Ala Ala Ala Gly Val Asp Ile Glu Ala Gly Asp Arg Ala Val 45 50 55 60gaa ctc ttt gca cca atg gcc aag cgc gcc acc cgc cca gag gtt ctt 242Glu Leu Phe Ala Pro Met Ala Lys Arg Ala Thr Arg Pro Glu Val Leu

65 70 75ggc aac ctc gga ggc ttc gca gga ctc ttt gag ctc gga aaa tac aag 290Gly Asn Leu Gly Gly Phe Ala Gly Leu Phe Glu Leu Gly Lys Tyr Lys

80 85 90aag cca atc ctc gca gca gga tct gac gga gtc ggc acc aag ctt gtc 338Lys Pro Ile Leu Ala Ala Gly Ser Asp Gly Val Gly Thr Lys Leu Val

95 100 105atc gcc cag atg atg gac aag cac gac acc atc ggc atc gac ctt gtt 386Ile Ala Gln Met Met Asp Lys His Asp Thr Ile Gly Ile Asp Leu Val

110 115 120gca atg tgt gtg gat gac ctc gtt gtc acc ggc gca gag cca ctg ttc 434Ala Met Cys Val Asp Asp Leu Val Val Thr Gly Ala Glu Pro Leu Phe125 130 135 140ctc cag gac tac atc gcc atc ggc aag gtt gtc cca gag cac gtt gct 482Leu Gln Asp Tyr Ile Ala Ile Gly Lys Val Val Pro Glu His Val Ala

145 150 155gag atc gtc tcc ggt atc gca gaa ggc tgt gtc cag gca ggc tgt gct 530Glu Ile Val Ser Gly Ile Ala Glu Gly Cys Val Gln Ala Gly Cys Ala

160 165 170ctg ctc ggt ggc gaa acc gca gaa cac cca ggt gtt atg gaa cca gac 578Leu Leu Gly Gly Glu Thr Ala Glu His Pro Gly Val Met Glu Pro Asp

175 180 185cac tac gat gtc tcc gca act gca gtc ggc gtt gtc gaa gca gat gaa 626His Tyr Asp Val Ser Ala Thr Ala Val Gly Val Val Glu Ala Asp Glu

190 195 200ctg cta gga cca gac cgc gtc cgc gca ggc gac gtc ctc atc ggc atg 674Leu Leu Gly Pro Asp Arg Val Arg Ala Gly Asp Val Leu Ile Gly Met205 210 215 220gct tcc tcc ggt ctg cac tcc aac ggt tac tcc ctg gct cgc cac gtc 722Ala Ser Ser Gly Leu His Ser Asn Gly Tyr Ser Leu Ala Arg His Val

225 230 235ctc ctg gaa aag gca ggc ctg gcg ctt gac gga cac atc gaa gaa ctc 770Leu Leu Glu Lys Ala Gly Leu Ala Leu Asp Gly His Ile Glu Glu Leu

240 245 250gga cgc acc ccc ggt gaa gaa ctt ctc gag cca acc cgc atg tac gcc 818Gly Arg Thr Pro Gly Glu Glu Leu Leu Glu Pro Thr Arg Met Tyr Ala

255260265<210>926<211>268<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>926Leu Leu Ser Pro Tyr Ala Trp Gly Leu Ser Arg Ala Leu Leu Asp Ser 151015 Tyr Val Pro Asn Lys Phe Gln Thr Pro Ala Gly Glu Ala Lys Tyr Thr

20 25 30Met Ser Asp His Gln Asp Thr Thr Ala Glu Gly Val Ser Tyr Ala Ala

35 40 45Ala Gly Val Asp Ile Glu Ala Gly Asp Arg Ala Val Glu Leu Phe Ala

50 55 60Pro Met Ala Lys Arg Ala Thr Arg Pro Glu Val Leu Gly Asn Leu Gly 65 70 75 80Gly Phe Ala Gly Leu Phe Glu Leu Gly Lys Tyr Lys Lys Pro Ile Leu

85 90 95Ala Ala Gly Ser Asp Gly Val Gly Thr Lys Leu Val Ile Ala Gln Met

100 105 110Met Asp Lys His Asp Thr Ile Gly Ile Asp Leu Val Ala Met Cys Val

115 120 125Asp Asp Leu Val Val Thr Gly Ala Glu Pro Leu Phe Leu Gln Asp Tyr

130 135 140Ile Ala Ile Gly Lys Val Val Pro Glu His Val Ala Glu Ile Val Ser145 150 155 160Gly Ile Ala Glu Gly Cys Val Gln Ala Gly Cys Ala Leu Leu Gly Gly

165 170 175Glu Thr Ala Glu His Pro Gly Val Met Glu Pro Asp His Tyr Asp Val

180 185 190Ser Ala Thr Ala Val Gly Val Val Glu Ala Asp Glu Leu Leu Gly Pro

195 200 205Asp Arg Val Arg Ala Gly Asp Val Leu Ile Gly Met Ala Ser Ser Gly

210 215 220Leu His Ser Asn Gly Tyr Ser Leu Ala Arg His Val Leu Leu Glu Lys225 230 235 240Ala Gly Leu Ala Leu Asp Gly His Ile Glu Glu Leu Gly Arg Thr Pro

245 250 255Gly Glu Glu Leu Leu Glu Pro Thr Arg Met Tyr Ala

260265<210>927<211>338<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) · (315)<223>FRXA00770<400>927gtc acc ggc ggc ggc ctc gca ggc aac ctc gag cgg gtt gtc cca gaa 48Val Thr Gly Gly Gly Leu Ala Gly Asn Leu Glu Arg Val Val Pro Glu 151015 ggg ctc gtc gca gaa atg tcc cga gca act tgg acc cca ggc caa atc 96Gly Leu Val Ala Glu Met Ser Arg Ala Thr Trp Thr Pro Gly Gln Ile

20 25 30ttc cgc acc atc tcc tct gtg ggc aag gtt tcc cgc gaa gaa atg gaa 144Phe Arg Thr Ile Ser Ser Val Gly Lys Val Ser Arg Glu Glu Met Glu

35 40 45aag acc ttc aac atg ggt gtc ggc atg gtt gca gtc gtt gct gaa aag 192Lys Thr Phe Asn Met Gly Val Gly Met Val Ala Val Val Ala Glu Lys

50 55 60gac cgc gac cgc gcc ctg gca atg ctc acc gca cgt cac att gac tgc 240Asp Arg Asp Arg Ala Leu Ala Met Leu Thr Ala Arg His Ile Asp Cys 65 70 75 80tgg gaa atc gga acc gta cgc aac ggt gaa gag gga gag cct cgc gtg 288Trp Glu Ile Gly Thr Val Arg Asn Gly Glu Glu Gly Glu Pro Arg Val

85 90 95atc ctc aac ggc gag cac cct ggc tac taagcccaac tgtctgctct 335Ile Leu Asn Gly Glu His Pro Gly Tyr

100105 aag 338<210>928<211>105<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>928Val Thr Gly Gly Gly Leu Ala Gly Asn Leu Glu Arg Val Val Pro Glu 151015 Gly Leu Val Ala Glu Met Ser Arg Ala Thr Trp Thr Pro Gly Gln Ile

20 25 30Phe Arg Thr Ile Ser Ser Val Gly Lys Val Ser Arg Glu Glu Met Glu

35 40 45Lys Thr Phe Asn Met Gly Val Gly Met Val Ala Val Val Ala Glu Lys

50 55 60Asp Arg Asp Arg Ala Leu Ala Met Leu Thr Ala Arg His Ile Asp Cys 65 70 75 80Trp Glu Ile Gly Thr Val Arg Asn Gly Glu Glu Gly Glu Pro Arg Val

85 90 95Ile Leu Asn Gly Glu His Pro Gly Tyr

100105<210>929<211>1320<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1297)<223>RXN02345<400>929accaccgacc ctatgtaatc aaccaggttc ccaaggctcg aaaagtggaa gcgctgctca 60aagatcttac attttggtga aggcgttata gttaggactt gtg act tct aca gga 115

Val Thr Ser Thr Gly

1 5aac caa gcc cac gct cca gga atg ccc atc gtc gca gta att ggt gac 163Asn Gln Ala His Ala Pro Gly Met Pro Ile Val Ala Val Ile Gly Asp

10 15 20ggc caa tta gcc cgc atg atg cag acc tcc gcc atc gaa ctc gga caa 211Gly Gln Leu Ala Arg Met Met Gln Thr Ser Ala Ile Glu Leu Gly Gln

25 30 35tca ctg cga gtt cta gct gga gcg ccg gat tcc tcc gca gct caa gta 259Ser Leu Arg Val Leu Ala Gly Ala Pro Asp Ser Ser Ala Ala Gln Val

40 45 50gct gct gat gtt gtt ctc ggc gat tac acc aac att gat gat ctg cgc 307Ala Ala Asp Val Val Leu Gly Asp Tyr Thr Asn Ile Asp Asp Leu Arg

55 60 65gtc gcc atc gaa ggc gcc gat gtg atg acc ttc gac cac gag cac gtc 355Val Ala Ile Glu Gly Ala Asp Val Met Thr Phe Asp His Glu His Val 70 75 80 85ccc aac gaa cac ctg cac caa ctc atc gca gaa ggc gtc aac gtt cag 403Pro Asn Glu His Leu His Gln Leu Ile Ala Glu Gly Val Asn Val Gln

90 95 100cca cgc cca gaa gcg ctg gtc aac gca caa gac aaa ctt gtc atg cgc 451Pro Arg Pro Glu Ala Leu Val Asn Ala Gln Asp Lys Leu Val Met Arg

105 110 115aag cgt cta cgt gaa ctc ggc gca cca gtc cca cca ttt gct gcc att 499Lys Arg Leu Arg Glu Leu Gly Ala Pro Val Pro Pro Phe AlaAla Ile

120 125 130gaa tca gtc gaa gat gca gtg gga ttc ttc gaa gca gtt gat ggc caa 547Glu Ser Val Glu Asp Ala Val Gly Phe Phe Glu Ala Val Asp Gly Gln

135 140 145gtt tgc ctc aaa gca cgc cgt ggc gga tac gac ggc aag ggc gta tgg 595Val Cys Leu Lys Ala Arg Arg Gly Gly Tyr Asp Gly Lys Gly Val Trp150 155 160 165ttc cca gcc gat gta gca gag ctt cag tcg ctt gtg gca gag ctt ctc 643Phe Pro Ala Asp Val Ala Glu Leu Gln Ser Leu Val Ala Glu Leu Leu

170 175 180gac ggc ggc acc cca ctc atg gca gaa aag aaa gtt gcc ctc aac agg 691Asp Gly Gly Thr Pro Leu Met Ala Glu Lys Lys Val Ala Leu Asn Arg

185 190 195gaa ctg tcc gcc atg gtt gcc cgc acc cca agt gga gaa acc aaa gcg 739Glu Leu Ser Ala Met Val Ala Arg Thr Pro Ser Gly Glu Thr Lys Ala

200 205 210tgg cca gtc gta gaa tca gtg cag aag aac ggt gtg tgt gca gaa gca 787Trp Pro Val Val Glu Ser Val Gln Lys Asn Gly Val Cys Ala Glu Ala

215 220 225atc gct ccc gca cct gaa cta tcc gca gaa ctg cag gaa tcc acc aga 835Ile Ala Pro Ala Pro Glu Leu Ser Ala Glu Leu Gln Glu Ser Thr Arg230 235 240 245gga ttg gcc cag aag atc gcc acg gaa ctc ggc gtc act ggt gtc ttg 883Gly Leu Ala Gln Lys Ile Ala Thr Glu Leu Gly Val Thr Gly Val Leu

250 255 260gca gtg gag ctt ttt gaa acc ctc gac caa aac ggg cag cca gag atc 931Ala Val Glu Leu Phe Glu Thr Leu Asp Gln Asn Gly Gln Pro Glu Ile

265 270 275tttgtc aac gag ctc gcc atg cgt tca cac aac acc ggc cac tgg act 979Phe Val Asn Glu Leu Ala Met Arg Ser His Asn Thr Gly His Trp Thr

280 285 290caa gat ggc tgc gtg acc agc caa ttc gag cag cac ctc cgc gca gtc 1027Gln Asp Gly Cys Val Thr Ser Gln Phe Glu Gln His Leu Arg Ala Val

295 300 305ctc gac tac cca ctg ggt gct acc gac act ttg gct gat tac acc gtg 1075Leu Asp Tyr Pro Leu Gly Ala Thr Asp Thr Leu Ala Asp Tyr Thr Val310 315 320 325atg gcc aac gtg ctc ggt gcc gac acc gac cca gag atg ccc atg gca 1123Met Ala Asn Val Leu Gly Ala Asp Thr Asp Pro Glu Met Pro Met Ala

330 335 340acc cgc atg gtg gaa gtg ggg cgc aag tac cca gat gcc aag att cac 1171Thr Arg Met Val Glu Val Gly Arg Lys Tyr Pro Asp Ala Lys Ile His

345 350 355ctc tac ggc aag gga cat cgc ccg gga cga aag att ggc cac gtc aac 1219Leu Tyr Gly Lys Gly His Arg Pro Gly Arg Lys Ile Gly His Val Asn

360 365 370atg gtg gga tcc gac ctt gaa aag acc cga gcc gaa gcc ctg gcc tgc 1267Met Val Gly Ser Asp Leu Glu Lys Thr Arg Ala Glu Ala Leu Ala Cys

375380385 gca tac ttc ctt gtc aac gct cgc tgg gat taggtctttt ctgagcgcta 1317Ala Tyr Phe Leu Val Asn Ala Arg Trp Asp 390395 gca 1320<210>930<211>399<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>930Val Thr Ser Thr Gly Asn Gln Ala His Ala Pro Gly Met Pro Ile Val 151015 Ala Val Ile Gly Asp Gly Gln Leu Ala Arg Met Met Gln Thr Ser Ala

20 25 30Ile Glu Leu Gly Gln Ser Leu Arg Val Leu Ala Gly Ala Pro Asp Ser

35 40 45Ser Ala Ala Gln Val Ala Ala Asp Val Val Leu Gly Asp Tyr Thr Asn

50 55 60Ile Asp Asp Leu Arg Val Ala Ile Glu Gly Ala Asp Val Met Thr Phe 65 70 75 80Asp His Glu His Val Pro Asn Glu His Leu His Gln Leu Ile Ala Glu

85 90 95Gly Val Asn Val Gln Pro Arg Pro Glu Ala Leu Val Asn Ala Gln Asp

100 105 110Lys Leu Val Met Arg Lys Arg Leu Arg Glu Leu Gly Ala Pro Val Pro

115 120 125Pro Phe Ala Ala Ile Glu Ser Val Glu Asp Ala Val Gly Phe Phe Glu

130 135 140Ala Val Asp Gly Gln Val Cys Leu Lys Ala Arg Arg Gly Gly Tyr Asp145 150 155 160Gly Lys Gly Val Trp Phe Pro Ala Asp Val Ala Glu Leu Gln Ser Leu

165 170 175Val Ala Glu Leu Leu Asp Gly Gly Thr Pro Leu Met Ala Glu Lys Lys

180 185 190Val Ala Leu Asn Arg Glu Leu Ser Ala Met Val Ala Arg Thr Pro Ser

195 200 205Gly Glu Thr Lys Ala Trp Pro Val Val Glu Ser Val Gln Lys Asn Gly

210 215 220Val Cys Ala Glu Ala Ile Ala Pro Ala Pro Glu Leu Ser Ala Glu Leu225 230 235 240Gln Glu Ser Thr Arg Gly Leu Ala Gln Lys Ile Ala Thr Glu Leu Gly

245 250 255Val Thr Gly Val Leu Ala Val Glu Leu Phe Glu Thr Leu Asp Gln Asn

260 265 270Gly Gln Pro Glu Ile Phe Val Asn Glu Leu Ala Met Arg Ser His Asn

275 280 285Thr Gly His Trp Thr Gln Asp Gly Cys Val Thr Ser Gln Phe Glu Gln

290 295 300His Leu Arg Ala Val Leu Asp Tyr Pro Leu Gly Ala Thr Asp Thr Leu305 310 315 320Ala Asp Tyr Thr Val Met Ala Asn Val Leu Gly Ala Asp Thr Asp Pro

325 330 335Glu Met Pro Met Ala Thr Arg Met Val Glu Val Gly Arg Lys Tyr Pro

340 345 350Asp Ala Lys Ile His Leu Tyr Gly Lys Gly His Arg Pro Gly Arg Lys

355 360 365Ile Gly His Val Asn Met Val Gly Ser Asp Leu Glu Lys Thr Arg Ala

370375380 Glu Ala Leu Ala Cys Ala Tyr Phe Leu Val Asn Ala Arg Trp Asp 385390395<210>931<211>833<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1).<810><223>FR023XA 45<400>931ttt gct gcc att gaa tca gtc gaa gat gca gtg gga ttc ttc gaa gca 48Phe Ala Ala Ile Glu Ser Val Glu Asp Ala Val Gly Phe Phe Glu Ala 151015 gtt gat ggc caa gtt tgc ctc aaa gca cgc cgt ggc gga tac gac ggc 96Val Asp Gly Gln Val Cys Leu Lys Ala Arg Arg Gly Gly Tyr Asp Gly<400>931 3526

20 25 30aag ggc gta tgg ttc cca gcc gat gta gca gag ctt cag tcg ctt gtg 144Lys Gly Val Trp Phe Pro Ala Asp Val Ala Glu Leu Gln Ser Leu Val

35 40 45gca gag ctt ctc gac ggc ggc acc cca ctc atg gca gaa aag aaa gtt 192Ala Glu Leu Leu Asp GlyGly Thr Pro Leu Met Ala Glu Lys Lys Val

50 55 60gcc ctc aac agg gaa ctg tcc gcc atg gtt gcc cgc acc cca agt gga 240Ala Leu Asn Arg Glu Leu Ser Ala Met Val Ala Arg Thr Pro Ser Gly 65 70 75 80gaa acc aaa gcg tgg cca gtc gta gaa tca gtg cag aag aac ggt gtg 288Glu Thr Lys Ala Trp Pro Val Val Glu Ser Val Gln Lys Asn Gly Val

85 90 95tgt gca gaa gca atc gct ccc gca cct gaa cta tcc gca gaa ctg cag 336Cys Ala Glu Ala Ile Ala Pro Ala Pro Glu Leu Ser Ala Glu Leu Gln

100 105 110gaa tcc acc aga gga ttg gcc cag aag atc gcc acg gaa ctc ggc gtc 384Glu Ser Thr Arg Gly Leu Ala Gln Lys Ile Ala Thr Glu Leu Gly Val

115 120 125act ggt gtc ttg gca gtg gag ctt ttt gaa acc ctc gac caa aac ggg 432Thr Gly Val Leu Ala Val Glu Leu Phe Glu Thr Leu Asp Gln Asn Gly

130 135 140cag cca gag atc ttt gtc aac gag ctc gcc atg cgt tca cac aac acc 480Gln Pro Glu Ile Phe Val Asn Glu Leu Ala Met Arg Ser His Asn Thr145 150 155 160ggc cac tgg act caa gat ggc tgc gtg acc agc caa ttc gag cag cac 528Gly His Trp Thr Gln Asp Gly Cys Val Thr Ser Gln Phe Glu Gln His

165 170 175ctc cgc gca gtc ctc gac tac cca ctg ggt gct acc gac act ttg gct 576Leu Arg Ala Val Leu Asp Tyr Pro Leu Gly Ala Thr Asp Thr Leu Ala

180 185 190gat tac acc gtg atg gcc aac gtg ctc ggt gcc gac acc gac cca gag 624Asp Tyr Thr Val Met Ala Asn Val Leu Gly Ala Asp Thr Asp Pro Glu

195200 205atg ccc atg gca acc cgc atg gtg gaa gtg ggg cgc aag tac cca gat 672Met Pro Met Ala Thr Arg Met Val Glu Val Gly Arg Lys Tyr Pro Asp

210 215 220gcc aag att cac ctc tac ggc aag gga cat cgc ccg gga cga aag att 720Ala Lys Ile His Leu Tyr Gly Lys Gly His Arg Pro Gly Arg Lys Ile225 230 235 240ggc cac gtc aac atg gtg gga tcc gac ctt gaa aag acc cga gcc gaa 768Gly His Val Asn Met Val Gly Ser Asp Leu Glu Lys Thr Arg Ala Glu

245 250 255gcc ctg gcc tgc gca tac ttc ctt gtc aac gct cgc tgg gat 810Ala Leu Ala Cys Ala Tyr Phe Leu Val Asn Ala Arg Trp Asp

260265270 taggtctttt ctgagcgcta gca 833<210>932<211>270<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>932Phe Ala lle Glu Ser Val Glu Asp Ala Val Gly Phe Phe Glu Ala 151015 Val Asp Gly Gln Val Cys Leu Lys Ala Arg Arg Gly Gly Tyr Asp Gly

20 25 30Lys Gly Val Trp Phe Pro Ala Asp Val Ala Glu Leu Gln Ser Leu Val

35 40 45Ala Glu Leu Leu Asp Gly Gly Thr Pro Leu Met Ala Glu Lys Lys Val

50 55 60Ala Leu Asn Arg Glu Leu Ser Ala Met Val Ala Arg Thr Pro Ser Gly 65 70 75 80Glu Thr Lys Ala Trp Pro Val Val Glu Ser Val Gln Lys Asn Gly Val

85 90 95Cys Ala Glu Ala Ile Ala Pro Ala Pro Glu Leu Ser Ala Glu Leu Gln

100 105 110Glu Ser Thr Arg Gly Leu Ala Gln Lys Ile Ala Thr Glu Leu Gly Val

115 120 125Thr Gly Val Leu Ala Val Glu Leu Phe Glu Thr Leu Asp Gln Asn Gly

130 135 140Gln Pro Glu Ile Phe Val Asn Glu Leu Ala Met Arg Ser His Asn Thr145 150 155 160Gly His Trp Thr Gln Asp Gly Cys Val Thr Ser Gln Phe Glu Gln His

165 170 175Leu Arg Ala Val Leu Asp Tyr Pro Leu Gly Ala Thr Asp Thr Leu Ala

180 185 190Asp Tyr Thr Val Met Ala Asn Val Leu Gly Ala Asp Thr Asp Pro Glu

195 200 205Met Pro Met Ala Thr Arg Met Val Glu Val Gly Arg Lys Tyr Pro Asp

210 215 220Ala Lys Ile His Leu Tyr Gly Lys Gly His Arg Pro Gly Arg Lys Ile225 230 235 240Gly His Val Asn Met Val Gly Ser Asp Leu Glu Lys Thr Arg Ala Glu

245 250 255Ala Leu Ala Cys Ala Tyr Phe Leu Val Asn Ala Arg Trp Asp

260265270<210>933<211>618<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (595)<223>RXN02350<400>933aagcatttct ccaacacttt tgatggacag attaacgctt aaaaggcctg ttatagactg 60ataaaccgat acgtactttt cgcgcttaag gagaatttca gtg ggt cct cta gtt 115

Val Gly Pro Leu Val

1 5ggt ttg atc atg ggt tcg gat tcg gat tgg gac act gta gcg cca gct 163Gly Leu Ile Met Gly Ser Asp Ser Asp Trp Asp Thr Val Ala Pro Ala

10 15 20gca gag gta ctc gct gag ttt ggc att cct ttt gaa gtc gga gtt gtc 211Ala Glu Val Leu Ala Glu Phe Gly Ile Pro Phe Glu Val Gly Val Val

25 30 35tct gca cac cgc acc cca gag aag atg ctc aac tac gca aag act gca 259Ser Ala His Arg Thr Pro Glu Lys Met Leu Asn Tyr Ala Lys Thr Ala

40 45 50cat gag cgc ggc atc aag acg atc atc gcg tgt gct ggc ggc gct gca 307His Glu Arg Gly Ile Lys Thr Ile Ile Ala Cys Ala Gly Gly Ala Ala

55 60 65cac ctg cca ggc atg gtg gct gca gca act cca ctt cca gtc atc ggt 355His Leu Pro Gly Met Val Ala Ala Ala Thr Pro Leu Pro Val Ile Gly 70 75 80 85gtt cca cgc gca ttg aag gat ctc gac ggt ttg gat tcc ttg ctg tcc 403Val Pro Arg Ala Leu Lys Asp Leu Asp Gly Leu Asp Ser Leu Leu Ser

90 95 100atc gtc cag atg cca ggc ggc gtt cca gtc gcc act gtc tcc atc ggt 451Ile Val Gln Met Pro Gly Gly Val Pro Val Ala Thr Val Ser Ile Gly

105 110 115ggc gcg aag aat gca ggc cta ctt gcc gtt cgt att ctc ggt gct ggt 499Gly Ala Lys Asn Ala Gly Leu Leu Ala Val Arg Ile Leu Gly Ala Gly

120 125 130gat cct tct ttg gtc acg aag atg gcc gat tac caa gag aat atg gcg 547Asp Pro Ser Leu Val Thr Lys Met Ala Asp Tyr Gln Glu Asn Met Ala

135140145 aag gaa gtt gaa gcc aag gac gaa gca ctg aag aag cgc ttg ctc ggc 595Lys Glu Val Glu Ala Lys Asp Glu Ala Leu Lys Lys Arg Leu Leu Gly 150155160165 taatgaatcc gatcgtggtg ctg 618<210>934<211>165<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>934Val Gly Pro Leu Val Gly Leu Ile Met Gly Ser Asp Ser Asp Trp Asp 151015 Thr Val Ala Pro Ala Ala Glu Val Leu Ala Glu Phe Gly Ile Pro Phe

20 25 30Glu Val Gly Val Val Ser Ala His Arg Thr Pro Glu Lys Met Leu Asn

35 40 45Tyr Ala Lys Thr Ala His Glu Arg Gly Ile Lys Thr Ile Ile Ala Cys

50 55 60Ala Gly Gly Ala Ala His Leu Pro Gly Met Val Ala Ala Ala Thr Pro 65 70 75 80Leu Pro Val Ile Gly Val Pro Arg Ala Leu Lys Asp Leu Asp Gly Leu

85 90 95 Asp Ser Leu Leu Ser Ile Val Gln Met Pro Gly Gly Val Pro Val Ala

100 105 110Thr Val Ser Ile Gly Gly Ala Lys Asn Ala Gly Leu Leu Ala Val Arg

115 120 125Ile Leu Gly Ala Gly Asp Pro Ser Leu Val Thr Lys Met Ala Asp Tyr

130 135 140Gln Glu Asn Met Ala Lys Glu Val Glu Ala Lys Asp Glu Ala Leu Lys145 150 155 160Lys Arg Leu Leu Gly

165<210>935<211>223<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (223)<223>FRXA02346<400>935aagcatttct ccaacacttt tgatggacag attaacgctt aaaaggcctg ttatagactg 60ataaaccgat acgtaacttt cgcgcttaag gagaatttca gtg ggt cct cta gtt 115

Val Gly Pro Leu Val

1 5ggt ttg atc atg ggt tcg gat tcg gat tgg gac act gta gcg cca gct 163Gly Leu Ile Met Gly Ser Asp Ser Asp Trp Asp Thr Val Ala Pro Ala

10 15 20gca gag gta ctc gct gag ttt ggc att cct ttt gaa gtc gga gtt gtc 211Ala Glu Val Leu Ala Glu Phe Gly Ile Pro Phe Glu Val Gly Val Val

25 30 35tct gca cac cgc 223Ser Ala His Arg

40<210>936<211>41<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>936Val Gly Pro Leu Val Gly Leu Ile Met Gly Ser Asp Ser Asp Trp Asp 151015 Thr Val Ala Pro Ala Ala Glu Val Leu Ala Glu Phe Gly Ile Pro Phe

20 25 30Glu Val Gly Val Val Ser Ala His Arg

3540<210>937<211>252<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(20) } (229)<223>FRXA02350<400>937atactaggat ctcgacggt ttg gat tcc ttg ctg tcc atc gtc cag atg cca 52

Leu Asp Ser Leu Leu Ser Ile Val Gln Met Pro

1 5 10ggc ggc gtt cca gtc gcc act gtc tcc atc ggt ggc gcg aag aat gca 100Gly Gly Val Pro Val Ala Thr Val Ser Ile Gly Gly Ala Lys Asn Ala

15 20 25ggc cta ctt gcc gtt cgt att ctc ggt gct ggt gat cct tct ttg gtc 148Gly Leu Leu Ala Val Arg Ile Leu Gly Ala Gly Asp Pro Ser Leu Val

30 35 40acg aag atg gcc gat tac caa gag aat atg gcg aag gaa gtt gaa gcc 196Thr Lys Met Ala Asp Tyr Gln Glu Asn Met Ala Lys Glu Val Glu Ala

455055 aag gac gaa gca ctg aag aag cgc ttg ctc ggc taatgaatcc gatcgtggtg 249Lys Asp Glu Ala Leu Lys Lys Arg Leu Leu Gly 606570 ctg 252<210>938<211>70<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>938Leu Asp Ser Leu Leu Ser Ile Val Gln Met Pro Gly Gly Val Pro Val 151015 Ala Thr Val Ser Ile Gly Gly Ala Lys Asn Ala Gly Leu Leu Ala Val

20 25 30Arg Ile Leu Gly Ala Gly Asp Pro Ser Leu Val Thr Lys Met Ala Asp

35 40 45Tyr Gln Glu Asn Met Ala Lys Glu Val Glu Ala Lys Asp Glu Ala Leu

505560 Lys Lys Arg Leu Leu Gly 6570<210>939<211>999<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220>CDS<222>(101).)

Met Gln Thr Leu Ala

1 5gct att gtt cgt gcc acg aag caa cct ttt gag atc acc acc att gat 163Ala Ile Val Arg Ala Thr Lys Gln Pro Phe Glu Ile Thr Thr Ile Asp

10 15 20ctg gat gca cca cga cca gat gaa gtt caa atc cgt gtt att gct gcc 211Leu Asp Ala Pro Arg Pro Asp Glu Val Gln Ile Arg Val Ile Ala Ala

25 30 35gga gtg cgc cac act gac gca att gtt cgt gat cag att tac cca act 259Gly Val Arg His Thr Asp Ala Ile Val Arg Asp Gln Ile Tyr Pro Thr

40 45 50ttt ctt ccc gca gtt ttc ggc cac gaa ggc gcc gga gta gtt gtc gcc 307Phe Leu Pro Ala Val Phe Gly His Glu Gly Ala Gly Val Val Val Ala

55 60 65gtg ggt tct gca gtc acctcg gtg aaa cca gat gac aag gta gtg ctg 355Val Gly Ser Ala Val Thr Ser Val Lys Pro Asp Asp Lys Val Val Leu 70 75 80 85gga ttc aac tct tgt ggc cag tgc ttg aag tgt ttg ggc ggt aag cct 403Gly Phe Asn Ser Cys Gly Gln Cys Leu Lys Cys Leu Gly Gly Lys Pro

90 95 100 gcg tac tgt gag aaa ttc tat gac cgc aac ttc gca tgc acc cgc gat 451Ala Tyr Cys Glu Lys Phe Tyr Asp Arg Asn Phe Ala Cys Thr Arg Asp

105 110 115gcc ggg cac act act ttg ttt acc cgt gca aca aaa gag cag gca gag 499Ala Gly His Thr Thr Leu Phe Thr Arg Ala Thr Lys Glu Gln Ala Glu

120 125 130gcc atc atc gac acc ctt gat gat gtt ttc tac gat gcg gat gcg ggt 547Ala Ile Ile Asp Thr Leu Asp Asp Val Phe Tyr Asp Ala Asp Ala Gly

135 140 145ttc ctg gca tac cca gca act ccc cca gag gct tcg gga gta agc gtg 595Phe Leu Ala Tyr Pro Ala Thr Pro Pro Glu Ala Ser Gly Val Ser Val150 155 160 165ttg gtt gtc gcg gct ggt acc tct gat ctc ccc caa gca aag gaa gca 643Leu Val Val Ala Ala Gly Thr Ser Asp Leu Pro Gln Ala Lys Glu Ala

170 175 180cta cac act gcc tcc tac ttg ggg cgc tcc acc tca ctg att gtt gat 691Leu His Thr Ala Ser Tyr Leu Gly Arg Ser Thr Ser Leu Ile Val Asp

185 190 195ttt gga gtg gct ggc atc cac cgc ctg ctt tca tac gaa gaa gaa ctc 739Phe Gly Val Ala Gly Ile His Arg Leu Leu Ser Tyr Glu Glu Glu Leu

200 205 210cgc gct gcg ggc gtg ctc atc gtt gcc gct gga atg gat ggt gcg cta 787Arg Ala Ala Gly Val Leu Ile ValAla Ala Gly Met Asp Gly Ala Leu

215 220 225ccc gga gtt gtc gca ggc tta gtg tcc gca cct gtc gtc gca ctg cca 835Pro Gly Val Val Ala Gly Leu Val Ser Ala Pro Val Val Ala Leu Pro230 235 240 245acc tcc gtg gga tac ggc gca ggt gct gga gga atc gca cca ctt ctg 883Thr Ser Val Gly Tyr Gly Ala Gly Ala Gly Gly Ile Ala Pro Leu Leu

250 255 260acc atg ctt aac gcc tgc gcg ccg gga gtt gga gtg gtc aac att gat 931Thr Met Leu Asn Ala Cys Ala Pro Gly Val Gly Val Val Asn Ile Asp

265 270 275aac ggc tat gga gca gga cac ctg gct gcg cag att gcg gcg agg 976Asn Gly Tyr Gly Ala Gly His Leu Ala Ala Gln Ile Ala Ala Arg

280285290 taagggtttc gcaggagacg aac 999<210>940<211>292<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>940Met Gln Thr Leu Ala Ala Ile Val Arg Ala Thr Lys Gln Pro Phe Glu 151015 Ile Thr Thr Ile Asp Leu Asp Ala Pro Arg Pro Asp Glu Val Gln Ile

20 25 30Arg Val Ile Ala Ala Gly Val Arg His Thr Asp Ala Ile Val Arg Asp

35 40 45Gln Ile Tyr Pro Thr Phe Leu Pro Ala Val Phe Gly His Glu Gly Ala

50 55 60Gly Val Val Val Ala Val Gly Ser Ala Val Thr Ser Val Lys Pro Asp 65 70 75 80Asp Lys Val Val Leu Gly Phe Asn Ser Cys Gly Gln Cys Leu Lys Cys

85 90 95Leu Gly Gly Lys Pro Ala Tyr Cys Glu Lys Phe Tyr Asp Arg Asn Phe

100 105 110AlaCys Thr Arg Asp Ala Gly His Thr Thr Leu Phe Thr Arg Ala Thr

115 120 125Lys Glu Gln Ala Glu Ala Ile Ile Asp Thr Leu Asp Asp Val Phe Tyr

130 135 140Asp Ala Asp Ala Gly Phe Leu Ala Tyr Pro Ala Thr Pro Pro Glu Ala145 150 155 160Ser Gly Val Ser Val Leu Val Val Ala Ala Gly Thr Ser Asp Leu Pro

165 170 175Gln Ala Lys Glu Ala Leu His Thr Ala Ser Tyr Leu Gly Arg Ser Thr

180 185 190Ser Leu Ile Val Asp Phe Gly Val Ala Gly Ile His Arg Leu Leu Ser

195 200 205Tyr Glu Glu Glu Leu Arg Ala Ala Gly Val Leu Ile Val Ala Ala Gly

210 215 220Met Asp Gly Ala Leu Pro Gly Val Val Ala Gly Leu Val Ser Ala Pro225 230 235 240Val Val Ala Leu Pro Thr Ser Val Gly Tyr Gly Ala Gly Ala Gly Gly

245 250 255Ile Ala Pro Leu Leu Thr Met Leu Asn Ala Cys Ala Pro Gly Val Gly

260 265 270Val Val Asn Ile Asp Asn Gly Tyr Gly Ala Gly His Leu Ala Ala Gln

275 280 285Ile Ala Ala Arg

290<210>941<211>1551<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1528)<223>RXA00619<400>941tcaaaggaag acaccattga aggtgtgcgc aaaatcggag aattcatcaa aaaatagcag 60cgactaggtt agtttcggtt cgtggggaat aataatttgc gtg gct gat aaa aag 115

Val Ala Asp Lys Lys

1 5aag atc gca aac gtc ctg tcg aac cgt tac gcc tcc gcg gaa ctt tct 163Lys Ile Ala Asn Val Leu Ser Asn Arg Tyr Ala Ser Ala Glu Leu Ser

10 15 20aac ctg tgg agt gcc gaa gag aag atc atc atg gag cgc cag ctc tgg 211Asn Leu Trp Ser Ala Glu Glu Lys Ile Ile Met Glu Arg Gln Leu Trp

25 30 35atc gcc gtg atg aaa gcc cag aaa gat ttg gga gtt gag atc cct gcc 259Ile Ala Val Met Lys Ala Gln Lys Asp Leu Gly Val Glu Ile Pro Ala

40 45 50gag gca att gaa tcc tat gaa gca gtg atc gac cag gtt gat ttg gca 307Glu Ala Ile Glu Ser Tyr Glu Ala Val Ile Asp Gln Val Asp Leu Ala

55 60 65agc atc gcc gat cgt gag cgc gtc acc cgc cac gat gtg aag gcc cgc 355Ser Ile Ala Asp Arg Glu Arg Val Thr Arg His Asp Val Lys Ala Arg 70 75 80 85atc gaa gaa ttc aat gca ctg gct ggc cat gag cac atc cac aag ggc 403Ile Glu Glu Phe Asn Ala Leu Ala Gly His Glu His Ile His Lys Gly

90 95 100atg acc tcc cgc gac ctc acc gaa aat gtt gaa cag ctg cag atc cac 451Met Thr Ser Arg Asp Leu Thr Glu Asn Val Glu Gln Leu Gln Ile His

105 110 115cgc tcc ctt gag ctg gtc cgc aac aag ggc att gca gtt gtt gca gct 499Arg Ser Leu Glu Leu Val Arg Asn Lys Gly Ile Ala Val Val Ala Ala

120 125 130atc gga tcc cgc gca gcg cag tac caa agc ctg gtc atg gct ggc cgt 547Ile Gly Ser Arg Ala Ala Gln Tyr Gln Ser Leu Val Met Ala Gly Arg

135 140 145tcc cac aac gtg gca gcg cag gca act acc ttg ggc aag cgt ttc gca 595Ser His Asn Val Ala Ala Gln Ala Thr Thr Leu Gly Lys Arg Phe Ala150 155 160 165acc gca gct gat gaa atg ctc gtg gca ctt gag cgc gtc acc gaa ctg 643Thr Ala Ala Asp Glu Met Leu Val Ala Leu Glu Arg Val Thr Glu Leu

170 175 180ctc aac cgc tac cca ctt cgc gga atc aag ggc cca atg gga acc gcc 691Leu Asn Arg Tyr Pro Leu Arg Gly Ile Lys Gly Pro Met Gly Thr Ala

185 190 195caa gac atg ctt gac ctc atg gaa ggc gac gag gct cgt ctc tcc gat 739Gln Asp Met Leu Asp Leu Met Glu Gly Asp Glu Ala Arg Leu Ser Asp

200 205 210ctg gaa acc cgc atc gca gca cac ctc ggc ttt gat cgc gtc ttc gac 787Leu Glu Thr Arg Ile Ala Ala His Leu Gly Phe Asp Arg Val Phe Asp

215 220 225tcc gtc ggc cag gtc tac cca cgt tcc ctt gac ttc gat gca gta tct 835Ser Val Gly Gln Val Tyr Pro Arg Ser Leu Asp Phe Asp Ala Val Ser230 235 240 245gct ctg gtt cag ctt ggc tcc ggc cca tca tcg ctg tcc cac acc att 883Ala Leu Val Gln Leu Gly Ser Gly Pro Ser Ser Leu Ser His Thr Ile

250 255 260cgt ctc atg gcc ggc acc gaa act gtt acc gaa ggt ttt aag gaa ggc 931Arg Leu Met Ala Gly Thr Glu Thr Val Thr Glu Gly Phe Lys Glu Gly

265 270 275cag gtc ggt tcc tct gca atg cct cac aag atg aac gct cgc tcc tgt 979Gln Val Gly Ser Ser Ala Met Pro His Lys Met Asn Ala Arg Ser Cys

280 285 290gag cgcgtg ggc ggc ctg cag gtt att ctt cgc gga tac ctc acc atg 1027Glu Arg Val Gly Gly Leu Gln Val Ile Leu Arg Gly Tyr Leu Thr Met

295 300 305gtt gct gat ctt tcc ggc cag cag tgg aac gaa ggc gat gtc ttc tgc 1075Val Ala Asp Leu Ser Gly Gln Gln Trp Asn Glu Gly Asp Val Phe Cys310 315 320 325tcc gtg atc cgc cgc gtt gca ctg cca gac gca ttc ttc gcg att gac 1123Ser Val Ile Arg Arg Val Ala Leu Pro Asp Ala Phe Phe Ala Ile Asp

330 335 340gga atg ttt gaa act ttc ctg aca gtc ctg gat gaa ttc ggt gca ttc 1171Gly Met Phe Glu Thr Phe Leu Thr Val Leu Asp Glu Phe Gly Ala Phe

345 350 355cct gcc atg atc gag cgc gaa ctt gag cgt tac ctg cca ttc ctg gca 1219Pro Ala Met Ile Glu Arg Glu Leu Glu Arg Tyr Leu Pro Phe Leu Ala

360 365 370act acc cgt atc ctc atg gcc gct gtc cgc gca ggc gtt ggc cgc gaa 1267Thr Thr Arg Ile Leu Met Ala Ala Val Arg Ala Gly Val Gly Arg Glu

375 380 385acc gca cac gaa gta atc aag gaa aac gct gtc gcg gtt gcc ctc aac 1315Thr Ala His Glu Val Ile Lys Glu Asn Ala Val Ala Val Ala Leu Asn390 395 400 405atg cgc gaa aat ggc ggt gac cag gac ctt atc cag cgc ctc gct gct 1363Met Arg Glu Asn Gly Gly Asp Gln Asp Leu Ile Gln Arg Leu Ala Ala 410 415 420gat gag cgc ctc cca atg agc gaa gct gac ctt gag gca gcg ctg gct 1411Asp Glu Arg Leu Pro Met Ser Glu Ala Asp Leu Glu Ala Ala Leu Ala

425 430 435gac cgc cac gcc ttc atc ggt gcc gct gag tcc cag gtc tcc cgt gtg 1459Asp Arg His Ala Phe Ile Gly Ala Ala Glu Ser Gln Val Ser ArgVal

440 445 450ctc gac cgc att cag gtg ctt gtc gac gcc cac ccc ggc gcc gca gac 1507Leu Asp Arg Ile Gln Val Leu Val Asp Ala His Pro Gly Ala Ala Asp

455460465 tac cga cca ggt gag att ctt taaaggtttt taacggcgtt cac 1551Tyr Arg Pro Gly Glu Ile Leu 470475<210>942<211>476<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>942Val Ala Asp Lys Lys Lys Ile Ala Asn Val Leu Ser Asn Arg Tyr Ala 151015 Ser Ala Glu Leu Ser Asn Leu Trp Ser Ala Glu Glu Lys Ile Ile Met

20 25 30Glu Arg Gln Leu Trp Ile Ala Val Met Lys Ala Gln Lys Asp Leu Gly

35 40 45Val Glu Ile Pro Ala Glu Ala Ile Glu Ser Tyr Glu Ala Val Ile Asp

50 55 60Gln Val Asp Leu Ala Ser Ile Ala Asp Arg Glu Arg Val Thr Arg His 65 70 75 80Asp Val Lys Ala Arg Ile Glu Glu Phe Asn Ala Leu Ala Gly His Glu

85 90 95His Ile His Lys Gly Met Thr Ser Arg Asp Leu Thr Glu Asn Val Glu

100 105 110Gln Leu Gln Ile His Arg Ser Leu Glu Leu Val Arg Asn Lys Gly Ile

115 120 125Ala Val Val Ala Ala Ile Gly Ser Arg Ala Ala Gln Tyr Gln Ser Leu

130 135 140Val Met Ala Gly Arg Ser His Asn Val Ala Ala Gln Ala Thr Thr Leu145 150 155 160Gly Lys Arg Phe Ala Thr Ala Ala Asp Glu Met Leu Val Ala Leu Glu

165 170 175Arg Val Thr Glu Leu Leu Asn Arg Tyr Pro Leu Arg Gly Ile Lys Gly

180 185 190Pro Met Gly Thr Ala Gln Asp Met Leu Asp Leu Met Glu Gly Asp Glu

195 200 205Ala Arg Leu Ser Asp Leu Glu Thr Arg Ile Ala Ala His Leu Gly Phe

210 215 220Asp Arg Val Phe Asp Ser Val Gly Gln Val Tyr Pro Arg Ser Leu Asp225 230 235 240Phe Asp Ala Val Ser Ala Leu Val Gln Leu Gly Ser Gly Pro Ser Ser

245 250 255Leu Ser His Thr Ile Arg Leu Met Ala Gly Thr Glu Thr Val Thr Glu

260 265 270Gly Phe Lys Glu Gly Gln Val Gly Ser Ser Ala Met Pro His Lys Met

275 280 285Asn Ala Arg Ser Cys Glu Arg Val Gly Gly Leu Gln Val Ile Leu Arg

290 295 300Gly Tyr Leu Thr Met Val Ala Asp Leu Ser Gly Gln Gln Trp Asn Glu305 310 315 320Gly Asp Val Phe Cys Ser Val Ile Arg Arg Val Ala Leu Pro Asp Ala

325 330 335Phe Phe Ala Ile Asp Gly Met Phe Glu Thr Phe Leu Thr Val Leu Asp

340 345 350Glu Phe Gly Ala Phe Pro Ala Met Ile Glu Arg Glu Leu Glu Arg Tyr

355 360 365Leu Pro Phe Leu Ala Thr Thr Arg Ile Leu Met Ala Ala Val Arg Ala

370 375 380Gly Val Gly Arg Glu Thr Ala His Glu Val Ile Lys Glu Asn Ala Val385 390 395 400Ala Val Ala Leu Asn Met Arg Glu Asn Gly Gly Asp Gln Asp Leu Ile

405 410 415Gln Arg Leu Ala Ala Asp Glu Arg Leu Pro Met Ser Glu Ala Asp Leu

420 425 430Glu Ala Ala Leu Ala Asp Arg His Ala Phe Ile Gly Ala Ala Glu Ser

435 440 445Gln Val Ser Arg Val Leu Asp Arg Ile Gln Val Leu Val Asp Ala His

450455460 Pro Gly Ala Ala Asp Tyr Arg Pro Gly Glu Ile Leu 465470475<210>943<211>1683<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1660)<223>RXA02622<400>943atcaagcagg ttgagcgtaa actcattgta gaagtcctga acagcgtgga attttcgcgt 60cagggtggcg tacaactcaa ctggagaggc taaatccttc atg agc gat gat cgt 115

Met Ser Asp Asp Arg

1 5aag gca att aaa cgc gca cta att agc gtg tat gac aag act ggc ctg 163Lys Ala Ile Lys Arg Ala Leu Ile Ser Val Tyr Asp Lys Thr Gly Leu

10 15 20gag gat cta gcc cag gca ctt cac cgc gag aac gtg gaa att gtt tcc 211Glu Asp Leu Ala Gln Ala Leu His Arg Glu Asn Val Glu Ile Val Ser

25 30 35acc gga tcc act gcg gcg aag att gct gag ctt ggt att cct gtt acc 259Thr Gly Ser Thr Ala Ala Lys Ile Ala Glu Leu Gly Ile Pro Val Thr

40 45 50ccg gtt gag gag ctc acc ggt ttc cct gag tgc ctt gag ggc cgt gtg 307Pro Val Glu Glu Leu Thr Gly Phe Pro Glu Cys Leu Glu Gly Arg Val

55 6065aag aca ctg cac cct aag gtt cac gct ggc atc ttg gcg gac acc cgc 355Lys Thr Leu His Pro Lys Val His Ala Gly Ile Leu Ala Asp Thr Arg 70 75 80 85aag gaa gac cac ctg cgt cag ctc aag gaa ctt gag gtc gcc cca ttc 403Lys Glu Asp His Leu Arg Gln Leu Lys Glu Leu Glu Val Ala Pro Phe

90 95 100cag ctt gtc gtg gtg aac ctg tac cca ttt gct gag acc gtt gcg tcc 451Gln Leu Val Val Val Asn Leu Tyr Pro Phe Ala Glu Thr Val Ala Ser

105 110 115ggc gcc gat ttc gat gct tgc gtt gag cag atc gac atc gga ggc cca 499Gly Ala Asp Phe Asp Ala Cys Val Glu Gln Ile Asp Ile Gly Gly Pro

120 125 130tcc atg gtt cgt gct gcg gca aag aac cac cca tct gtc gct gtg gtt 547Ser Met Val Arg Ala Ala Ala Lys Asn His Pro Ser Val Ala Val Val

135 140 145gtt tca ccg aac cgc tac gag gat gtc cag gaa gct ttg aag acc ggt 595Val Ser Pro Asn Arg Tyr Glu Asp Val Gln Glu Ala Leu Lys Thr Gly150 155 160 165gga ttc tcc cgc gcg gag cgc acc aag ttg gct gct gag gct ttc cgc 643Gly Phe Ser Arg Ala Glu Arg Thr Lys Leu Ala Ala Glu Ala Phe Arg

170 175 180cac acc gca acc tac gat gtc acc gtt gca acc tgg atg agc gag cag 691His Thr Ala Thr Tyr Asp Val Thr Val Ala Thr Trp Met Ser Glu Gln

185 190 195ctg gct gcc gaa gat tct gag act gag ttc cca ggt tgg atc ggc acc 739Leu Ala Ala Glu Asp Ser Glu Thr Glu Phe Pro Gly Trp Ile Gly Thr

200 205 210acc aac acc ttg tcc cgc agc ttg cgt tac ggt gag aac cct cac cag 787Thr AsnThr Leu Ser Arg Ser Leu Arg Tyr Gly Glu Asn Pro His Gln

215 220 225tct gca gct ttg tac gtg ggc aac acc cgc gga ctt gca cag gct aag 835Ser Ala Ala Leu Tyr Val Gly Asn Thr Arg Gly Leu Ala Gln Ala Lys230 235 240 245cag ttc cac ggc aag gaa atg agc tac aac aac tac acc gat tct gat 883Gln Phe His Gly Lys Glu Met Ser Tyr Asn Asn Tyr Thr Asp Ser Asp

250 255 260gct gca tgg cgt gca gcg tgg gat cac gag cgt cct tgt gta gct atc 931Ala Ala Trp Arg Ala Ala Trp Asp His Glu Arg Pro Cys Val Ala Ile

265 270 275atc aag cat gca aac cct tgt ggc att gct gtt tct gat gag tcc atc 979Ile Lys His Ala Asn Pro Cys Gly Ile Ala Val Ser Asp Glu Ser Ile

280 285 290gca gcg gca cac cgc gag gca cac gca tgt gac tct gtg tcc gca ttc 1027Ala Ala Ala His Arg Glu Ala His Ala Cys Asp Ser Val Ser Ala Phe

295 300 305ggt ggc gtc atc gcg tcc aac cgt gaa gtc agc gtt gag atg gct aac 1075Gly Gly Val Ile Ala Ser Asn Arg Glu Val Ser Val Glu Met Ala Asn310 315 320 325cag gtt gca gag atc ttc act gag gtc atc atc gct cct tcc tat gaa 1123Gln Val Ala Glu Ile Phe Thr Glu Val Ile Ile Ala Pro Ser Tyr Glu

330 335 340gag ggc gct gtg gag atc ctg agc cag aag aag aac atc cgt att ctt 1171Glu Gly Ala Val Glu Ile Leu Ser Gln Lys Lys Asn Ile Arg Ile Leu

345 350 355cag gct gaa gca cct gtg cgt aag ggc ttt gag tcc cgt gag atc tcc 1219Gln Ala Glu Ala Pro Val Arg Lys Gly Phe Glu Ser Arg Glu Ile Ser

360 365 370ggc ggt ctg ctt gtt cag gaa cgc gac ttg atc cac gct gag ggc gac 1267Gly Gly Leu Leu Val Gln Glu Arg Asp Leu Ile His Ala Glu Gly Asp

375 380 385aac tcc gca aac tgg act ctt gct gcc ggc tct gct gtt tct cct gag 1315Asn Ser Ala Asn Trp Thr Leu Ala Ala Gly Ser Ala Val Ser Pro Glu390 395 400 405gtt ctg aag gac ctg gag ttc gcg tgg act gca gtt cgt tcc gtg aag 1363Val Leu Lys Asp Leu Glu Phe Ala Trp Thr Ala Val Arg Ser Val Lys

410 415 420tcc aac gca att ctg ttg gct aag aac ggc gct acc gtt ggc gtt ggc 1411Ser Asn Ala Ile Leu Leu Ala Lys Asn Gly Ala Thr Val Gly Val Gly

425 430 435atg gga cag gtc aac cgc gtt gac tct gct cgc ttg gct gtc gac cgt 1459Met Gly Gln Val Asn Arg Val Asp Ser Ala Arg Leu Ala Val Asp Arg

440 445 450gca ggt gca gag cgc gct acc ggt tcc gtt gct gct tcc gat gcg ttc 1507Ala Gly Ala Glu Arg Ala Thr Gly Ser Val Ala Ala Ser Asp Ala Phe

455 460 465ttc cca ttc gct gat ggc ttt gag gtt ctc gct gag gct ggc atc act 1555Phe Pro Phe Ala Asp Gly Phe Glu Val Leu Ala Glu Ala Gly Ile Thr470 475 480 485gct gtt gtg cag cct ggt gga tcc att cgc gac aac gag gtc att gag 1603Ala Val Val Gln Pro Gly Gly Ser Ile Arg Asp Asn Glu Val Ile Glu

490 495 500gca gcc aac aag gct ggc gtg acc atg tac ctg act ggt gcg cga cac 1651Ala Ala Asn Lys Ala Gly Val Thr Met Tyr Leu Thr Gly Ala Arg His

505 510 515ttc gct cac taaagttttt aaagatttcg ctt 1683Phe Ala His

520<210>944<211>520<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>944Met Ser Asp Asp Arg Lys Ala Ile Lys Arg Ala Leu Ile Ser Val Tyr 151015 Asp Lys Thr Gly Leu Glu Asp Leu Ala Gln Ala Leu His Arg Glu Asn

20 25 30Val Glu Ile Val Ser Thr Gly Ser Thr Ala Ala Lys Ile Ala Glu Leu

35 40 45Gly Ile Pro Val Thr Pro Val Glu Glu Leu Thr Gly Phe Pro Glu Cys

50 55 60Leu Glu Gly Arg Val Lys Thr Leu His Pro Lys Val His Ala Gly Ile 65 70 75 80Leu Ala Asp Thr Arg Lys Glu Asp His Leu Arg Gln Leu Lys Glu Leu

85 90 95Glu Val Ala Pro Phe Gln Leu Val Val Val Asn Leu Tyr Pro Phe Ala

100 105 110Glu Thr Val Ala Ser Gly Ala Asp Phe Asp Ala Cys Val Glu Gln Ile

115 120 125Asp Ile Gly Gly Pro Ser Met Val Arg Ala Ala Ala Lys Asn His Pro

130 135 140Ser Va1 Ala Val Val Val Ser Pro Asn Arg Tyr Glu Asp Val Gln Glu145 150 155 160Ala Leu Lys Thr Gly Gly Phe Ser Arg Ala Glu Arg Thr Lys Leu Ala

165 170 175Ala Glu Ala Phe Arg His Thr Ala Thr Tyr Asp Val Thr Val Ala Thr

180 185 190Trp Met Ser Glu Gln Leu Ala Ala Glu Asp Ser Glu Thr Glu Phe Pro

195 200205Gly Trp Ile Gly Thr Thr Asn Thr Leu Ser Arg Ser Leu Arg Tyr Gly

210 215 220Glu Asn Pro His Gln Ser Ala Ala Leu Tyr Val Gly Asn Thr Arg Gly225 230 235 240Leu Ala Gln Ala Lys Gln Phe His Gly Lys Glu Met Ser Tyr Asn Asn

245 250 255Tyr Thr Asp Ser Asp Ala Ala Trp Arg Ala Ala Trp Asp His Glu Arg

260 265 270Pro Cys Val Ala Ile Ile Lys His Ala Asn Pro Cys Gly Ile Ala Val

275 280 285Ser Asp Glu Ser Ile Ala Ala Ala His Arg Glu Ala His Ala Cys Asp

290 295 300Ser Val Ser Ala Phe Gly Gly Val Ile Ala Ser Asn Arg Glu Val Ser305 310 315 320Val Glu Met Ala Asn Gln Val Ala Glu Ile Phe Thr Glu Val Ile Ile

325 330 335Ala Pro Ser Tyr Glu Glu Gly Ala Val Glu Ile Leu Ser Gln Lys Lys

340 345 350Asn Ile Arg Ile Leu Gln Ala Glu Ala Pro Val Arg Lys Gly Phe Glu

355 360 365Ser Arg Glu Ile Ser Gly Gly Leu Leu Val Gln Glu Arg Asp Leu Ile

370 375 380His Ala Glu Gly Asp Asn Ser Ala Asn Trp Thr Leu Ala Ala Gly Ser385 390 395 400Ala Val Ser Pro Glu Val Leu Lys Asp Leu Glu Phe Ala Trp Thr Ala

405 410 415Val Arg Ser Val Lys Ser Asn Ala Ile Leu Leu Ala Lys Asn Gly Ala

420425 430Thr Val Gly Val Gly Met Gly Gln Val Asn Arg Val Asp Ser Ala Arg

435 440 445Leu Ala Val Asp Arg Ala Gly Ala Glu Arg Ala Thr Gly Ser Val Ala

450 455 460Ala Ser Asp Ala Phe Phe Pro Phe Ala Asp Gly Phe Glu Val Leu Ala465 470 475 480Glu Ala Gly Ile Thr Ala Val Val Gln Pro Gly Gly Ser Ile Arg Asp

485 490 495Asn Glu Val Ile Glu Ala Ala Asn Lys Ala Gly Val Thr Met Tyr Leu

500 505 510Thr Gly Ala Arg His Phe Ala His

515520<210>945<211>1641<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1618)<223>RXN00488<400>945gttgtggaat agcgtgtgag ctgcagcggt tatccgattt aaggacaagc tactaaagtt 60tagataattg tggacacact atgaggagga actgtcgcac atg aca acc cag agc 115

Met Thr Thr Gln Ser

1 5cga gtt tct acc gga gga gac aac cca aac aag gtt gcc ctt gtt gga 163Arg Val Ser Thr Gly Gly Asp Asn Pro Asn Lys Val Ala Leu Val Gly

10 15 20tta acc ttt gat gac gta ctt ttg ctt cca gat gcg tcg gac gtt gtt 211Leu Thr Phe Asp Asp Val Leu Leu Leu Pro Asp Ala Ser Asp Val Val

25 30 35cct tca gag gta gat acc tcg acg cag tta aca cgt aat att cgc ctt 259Pro Ser Glu Val Asp Thr Ser Thr Gln Leu Thr Arg Asn Ile Arg Leu

40 4550aac acc cct att ctt tct gcc gca atg gat act gtc acc gag gct cgc 307Asn Thr Pro Ile Leu Ser Ala Ala Met Asp Thr Val Thr Glu Ala Arg

55 60 65atg gct atc ggc atg gca cgc cat ggc ggc att ggt gtt ttg cac cgc 355Met Ala Ile Gly Met Ala Arg His Gly Gly Ile Gly Val Leu His Arg 70 75 80 85aac ctg tct att caa gag cag gca gaa aac gtt gag ctg gtg aag cgt 403Asn Leu Ser Ile Gln Glu Gln Ala Glu Asn Val Glu Leu Val Lys Arg

90 95 100tct gag tct gga atg gtc act gat cct gtt acc tgt act cct gac atg 451Ser Glu Ser Gly Met Val Thr Asp Pro Val Thr Cys Thr Pro Asp Met

105 110 115agc atc caa gaa gtg gat gat ctg tgt gca cgc ttc cgc att tcc ggt 499Ser Ile Gln Glu Val Asp Asp Leu Cys Ala Arg Phe Arg Ile Ser Gly

120 125 130ctg cct gtt gtt gat gag gcc gga aag ttg gtt ggt att tgc acc aac 547Leu Pro Val Val Asp Glu Ala Gly Lys Leu Val Gly Ile Cys Thr Asn

135 140 145cgc gat atg cgt ttt gaa agc gac atg aac cgt cgt gtc gct gaa gtt 595Arg Asp Met Arg Phe Glu Ser Asp Met Asn Arg Arg Val Ala Glu Val150 155 160 165atg acc cca atg cct ttg gtt gtt gct gaa gag ggc gtc acc aag gag 643Met Thr Pro Met Pro Leu Val Val Ala Glu Glu Gly Val Thr Lys Glu

170 175 180cag gct ctt gct ttg ctg tct gca aac aag gtg gag aag ctt cct atc 691Gln Ala Leu Ala Leu Leu Ser Ala Asn Lys Val Glu Lys Leu Pro Ile

185 190 195atc gca aag gac ggc aag ctt gtc ggt ctg atc acg gtg aag gac ttc 739Ile Ala LysAsp Gly Lys Leu Val Gly Leu Ile Thr Val Lys Asp Phe

200 205 210gtt aag act gag cag cac ccg aac gca tcc aag gat gca tca ggt cgt 787Val Lys Thr Glu Gln His Pro Asn Ala Ser Lys Asp Ala Ser Gly Arg

215 220 225ctg ctg gtt gcg gct ggc atc ggc acg ggc gag gag tca ttc cag cga 835Leu Leu Val Ala Ala Gly Ile Gly Thr Gly Glu Glu Ser Phe Gln Arg230 235 240 245gct ggt gcg ctt gcc gac gcc ggc gtc gac att ttg gtc gta gac tct 883Ala Gly Ala Leu Ala Asp Ala Gly Val Asp Ile Leu Val Val Asp Ser

250 255 260gca cac gcc cat agc cgt gga gtt ttg gac atg gtg tcc cgc gtg aag 931Ala His Ala His Ser Arg Gly Val Leu Asp Met Val Ser Arg Val Lys

265 270 275aag tcg ttc ccc aag gtc gat atc gtt ggc ggc aac ttg gcg acc cgc 979Lys Ser Phe Pro Lys Val Asp Ile Val Gly Gly Asn Leu Ala Thr Arg

280 285 290gag gct gcg cag gcc atg att gaa gct ggc gca gac gct atc aag gtg 1027Glu Ala Ala Gln Ala Met Ile Glu Ala Gly Ala Asp Ala Ile Lys Val

295 300 305ggt att ggc cca ggt tct att tgc acc act cgc gtt gtc gca ggt gtc 1075Gly Ile Gly Pro Gly Ser Ile Cys Thr Thr Arg Val Val Ala Gly Val310 315 320 325ggt gca cct cag atc act gcg atc atg gag gca gct gtt cca gct cac 1123Gly Ala Pro Gln Ile Thr Ala Ile Met Glu Ala Ala Val Pro Ala His

330 335 340aag gct ggc gtt cct atc atc gcc gat ggc ggc atg cag ttc tct ggt 1171Lys Ala Gly Val Pro Ile Ile Ala Asp Gly Gly Met Gln Phe Ser Gly

345 350 355gat atc gct aag gct ttg gct gct ggc gct aac tcc gtg atg ctg ggc 1219Asp Ile Ala Lys Ala Leu Ala Ala Gly Ala Asn Ser Val Met Leu Gly

360 365 370tcc atg ctg gct ggt acc gct gag gct cct ggt gag acc atc acc atc 1267Ser Met Leu Ala Gly Thr Ala Glu Ala Pro Gly Glu Thr Ile Thr Ile

375 380 385aac ggc aag cag tac aag cgt tac cgc ggc atg ggc tcc atg ggc gct 1315Asn Gly Lys Gln Tyr Lys Arg Tyr Arg Gly Met Gly Ser Met Gly Ala390 395 400 405atg cag ggc cgt gga ctt agt ggt gag aag cgt tcc tac tcc aag gac 1363Met Gln Gly Arg Gly Leu Ser Gly Glu Lys Arg Ser Tyr Ser Lys Asp

410 415 420cgt tac ttc cag tct gac gtt aag agc gaa gac aag ctc gtt cca gaa 1411Arg Tyr Phe Gln Ser Asp Val Lys Ser Glu Asp Lys Leu Val Pro Glu

425 430 435ggc atc gaa ggt cgc gtg cct ttc cgc ggt ccc atc gga gac atc att 1459Gly Ile Glu Gly Arg Val Pro Phe Arg Gly Pro Ile Gly Asp Ile Ile

440 445 450cac cag cag gtc ggt gga ctt cgt gca gca atg ggc tac acc ggt tcc 1507His Gln Gln Val Gly Gly Leu Arg Ala Ala Met Gly Tyr Thr Gly Ser

455 460 465tcc acc att gaa gag ctg cac aac gct cgt ttc gtg cag atc acc agc 1555Ser Thr Ile Glu Glu Leu His Asn Ala Arg Phe Val Gln Ile Thr Ser470 475 480 485gcg ggt ctg aag gaa tcc cac ccg cac cac atc cag cag act gtg gaa 1603Ala Gly Leu Lys Glu Ser His Pro His His Ile Gln Gln Thr Val Glu

490 495 500gct cct aac tac cac tagattttgc tcacttaaac agc 1641Ala Pro Asn Tyr His

505<210>946<211>506<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>946Met Thr Thr Gln Ser Arg Val Ser Thr Gly Gly Asp Asn Pro Asn Lys 151015 Val Ala Leu Val Gly Leu Thr Phe Asp Asp Val Leu Leu Leu Pro Asp

20 25 30Ala Ser Asp Val Val Pro Ser Glu Val Asp Thr Ser Thr Gln Leu Thr

35 40 45Arg Asn Ile Arg Leu Asn Thr Pro Ile Leu Ser Ala Ala Met Asp Thr

50 55 60Val Thr Glu Ala Arg Met Ala Ile Gly Met Ala Arg His Gly Gly Ile 65 70 75 80Gly Val Leu His Arg Asn Leu Ser Ile Gln Glu Gln Ala Glu Asn Val

85 90 95 Glu Leu Val Lys Arg Ser Glu Ser Gly Met Val Thr Asp Pro Val Thr

100 105 110Cys Thr Pro Asp Met Ser Ile Gln Glu Val Asp Asp Leu Cys Ala Arg

115 120 125Phe Arg Ile Ser Gly Leu Pro Val Val Asp Glu Ala Gly Lys Leu Val

130 135 140Gly Ile Cys Thr Asn Arg Asp Met Arg Phe Glu Ser Asp Met Asn Arg145 150 155 160Arg Val Ala Glu Val Met Thr Pro Met Pro Leu Val Val Ala Glu Glu

165 170 175Gly Val Thr Lys Glu Gln Ala Leu Ala Leu Leu Ser Ala Asn Lys Val

180 185 190Glu Lys Leu Pro Ile Ile Ala Lys Asp Gly Lys Leu Val Gly Leu Ile

195 200 205Thr Val Lys Asp Phe Val Lys Thr Glu Gln His Pro Asn Ala Ser Lys

210 215 220Asp Ala Ser Gly Arg Leu Leu Val Ala Ala Gly Ile Gly Thr Gly Glu225 230 235 240Glu Ser Phe Gln Arg Ala Gly Ala Leu Ala Asp Ala Gly Val Asp Ile

245 250 255Leu Val Val Asp Ser Ala His Ala His Ser Arg Gly Val Leu Asp Met

260 265 270Val Ser Arg Val Lys Lys Ser Phe Pro Lys Val Asp Ile Val Gly Gly

275 280 285Asn Leu Ala Thr Arg Glu Ala Ala Gln Ala Met Ile Glu Ala Gly Ala

290 295 300Asp Ala Ile Lys Val Gly Ile Gly Pro Gly Ser Ile Cys Thr Thr Arg305 310 315 320Val Val Ala Gly Val Gly Ala Pro Gln Ile Thr Ala Ile Met Glu Ala

325 330 335Ala Val Pro Ala His Lys Ala Gly Val Pro Ile Ile Ala Asp Gly Gly

340 345 350Met Gln Phe Ser Gly Asp Ile Ala Lys Ala Leu Ala Ala Gly Ala Asn

355 360 365Ser Val Met Leu Gly Ser Met Leu Ala Gly Thr Ala Glu Ala Pro Gly

370 375 380Glu Thr Ile Thr Ile Asn Gly Lys Gln Tyr Lys Arg Tyr Arg Gly Met385 390 395 400Gly Ser Met Gly Ala Met Gln Gly Arg Gly Leu Ser Gly Glu Lys Arg

405 410 415Ser Tyr Ser Lys Asp Arg Tyr Phe Gln Ser Asp Val Lys Ser Glu Asp

420 425 430Lys Leu Val Pro Glu Gly Ile Glu Gly Arg Val Pro Phe Arg Gly Pro

435 440 445Ile Gly Asp Ile Ile His Gln Gln Val Gly Gly Leu Arg Ala Ala Met

450 455 460Gly Tyr Thr Gly Ser Ser Thr Ile Glu Glu Leu His Asn Ala Arg Phe465 470 475 480Val Gln Ile Thr Ser Ala Gly Leu Lys Glu Ser His Pro His His Ile

485 490 495Gln Gln Thr Val Glu Ala Pro Asn Tyr His

500505<210>947<211>574<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (574)<223>FRXA00492<400>947gttgtggaat agcgtgtgag ctgcagcggt tatccgattt aaggacaagc tactaaagtt 60tagataattg tggacacact atgaggagga actgtcgcac atg aca acc cag agc 115

Met Thr Thr Gln Ser

1 5cga gtt tct acc gga gga gac aac cca aac aag gtt gcc ctt gtt gga 163Arg Val Ser Thr Gly Gly Asp Asn Pro Asn Lys Val Ala Leu Val Gly

10 15 20tta acc ttt gat gac gta ctt ttg ctt cca gat gcg tcg gac gtt gtt 211Leu Thr Phe Asp Asp Val Leu Leu Leu Pro Asp Ala Ser Asp Val Val

25 30 35cct tca gag gta gat acc tcg acg cag tta aca cgt aat att cgc ctt 259Pro Ser Glu Val Asp Thr Ser Thr Gln Leu Thr Arg Asn Ile Arg Leu

40 45 50aac acc cct att ctt tct gcc gca atg gat act gtc acc gag gct cgc 307Asn Thr Pro Ile Leu Ser Ala Ala Met Asp Thr Val Thr Glu Ala Arg

55 60 65atg gct atc ggc atg gca cgc cat ggc ggc att ggt gtt ttg cac cgc 355Met Ala Ile Gly Met Ala Arg His Gly Gly Ile Gly Val Leu His Arg 70 75 80 85aac ctg tct att caa gag cag gca gaa aac gtt gag ctg gtg aag cgt 403Asn Leu Ser Ile Gln Glu Gln Ala Glu Asn Val Glu Leu Val Lys Arg

90 95 100tct gag tct gga atg gtc act gat cct gtt acc tgt act cct gac atg 451Ser Glu Ser Gly Met Val Thr Asp Pro Val Thr Cys Thr Pro Asp Met

105 110 115agc atc caa gaa gtg gat gat ctg tgt gca cgc ttc cgc att tcc ggt 499Ser Ile Gln Glu Val Asp Asp Leu Cys Ala Arg Phe Arg Ile Ser Gly

120 125 130ctg cct gtt gtt gat gag gcc gga aag ttg gtt ggt att tgc acc aac 547Leu Pro Val Val Asp Glu Ala Gly Lys Leu Val Gly Ile Cys Thr Asn

135140145 cgc gat atg cgt ttt gaa agc gac atg 574Arg Asp Met Arg Phe Glu Ser Asp Met 150155<210>948<211>158<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>948Met Thr Thr Gln Ser Arg Val Ser Thr Gly Gly Asp Asn Pro Asn Lys 151015 Val Ala Leu Val Gly Leu Thr Phe Asp Asp Val Leu Leu Leu Pro Asp

20 25 30Ala Ser Asp Val Val Pro Ser Glu Val Asp Thr Ser Thr Gln Leu Thr

35 40 45Arg Asn Ile Arg Leu Asn Thr Pro Ile Leu Ser Ala Ala Met Asp Thr

50 55 60Val Thr Glu Ala Arg Met Ala Ile Gly Met Ala Arg His Gly Gly Ile 65 70 75 80Gly Val Leu His Arg Asn Leu Ser Ile Gln Glu Gln Ala Glu Asn Val

85 90 95Glu Leu Val Lys Arg Ser Glu Ser Gly Met Val Thr Asp Pro Val Thr

100 105 110Cys Thr Pro Asp Met Ser Ile Gln Glu Val Asp Asp Leu Cys Ala Arg

115 120 125Phe Arg Ile Ser Gly Leu Pro Val Val Asp Glu Ala Gly Lys Leu Val

130135140 Gly Ile Cys Thr Asn Arg Asp Met Arg Phe Glu Ser Asp Met 145150155<210>949<211>557<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) · (534)<223>FRXA00488<400>949cag atc act gcg atc atg gag gca gct gtt cca gct cac aag gct ggc 48Gln Ile Thr Ala Ile Met Glu Ala Ala Val Pro Ala His Lys Ala Gly 151015 gtt cct atc atc gcc gat ggc ggc atg cag ttc tct ggt gat atc gct 96Val Pro Ile Ile Ala Asp Gly Gly Met Gln Phe Ser Gly Asp Ile Ala<400>949cag atc act gcg atc atg gag gca gct gtt cca gct cac aag gct ggc 3526 gtt cct atc atc gcc gat ggc ggc atg cag ttc tct ggt gat atc gct

20 25 30aag gct ttg gct gct ggc gct aac tcc gtg atg ctg ggc tcc atg ctg 144Lys Ala Leu Ala Ala Gly Ala Asn Ser Val Met Leu Gly Ser Met Leu

35 40 45gct ggt acc gct gag gct cct ggt gag acc atc acc atc aac ggc aag 192Ala Gly Thr Ala Glu Ala Pro Gly Glu Thr Ile Thr Ile Asn Gly Lys

50 55 60cag tac aag cgt tac cgc ggc atg ggc tcc atg ggc gct atg cag ggc 240Gln Tyr Lys Arg Tyr Arg Gly Met Gly Ser Met Gly Ala Met Gln Gly 65 70 75 80cgt gga ctt agt ggt gag aag cgt tcc tac tcc aag gac cgt tac ttc 288Arg Gly Leu Ser Gly Glu Lys Arg Ser Tyr Ser Lys Asp Arg Tyr Phe

85 90 95cag tct gac gtt aag agc gaa gac aag ctc gtt cca gaa ggc atc gaa 336Gln Ser Asp Val Lys Ser Glu Asp Lys Leu Val Pro Glu Gly Ile Glu

100 105 110ggt cgc gtg cct ttc cgc ggt ccc atc gga gac atc att cac cag cag 384Gly Arg Val Pro Phe Arg Gly Pro Ile Gly Asp Ile Ile His Gln Gln

115 120 125gtc ggt gga ctt cgt gca gca atg ggc tac acc ggt tcc tcc acc att 432Val Gly Gly Leu Arg Ala Ala Met Gly Tyr Thr Gly Ser Ser Thr Ile

130 135 140gaa gag ctg cac aac gct cgt ttc gtg cag atc acc agc gcg ggt ctg 480Glu Glu Leu His Asn Ala Arg Phe Val Gln Ile Thr Ser Ala Gly Leu145 150 155 160aag gaa tcc cac ccg cac cac atc cag cag act gtg gaa gct cct aac 528Lys Glu Ser His Pro His His Ile Gln Gln Thr Val Glu Ala Pro Asn

165170175 tac cac tagattttgc tcacttaaac agc 557Tyr His<210>950<211>178<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>950Gln Ile Thr Ala Ile Met Glu Ala Ala Val Pro Ala His Lys Ala Gly 151015 Val Pro Ile Ile Ala Asp Gly Gly Met Gln Phe Ser Gly Asp Ile Ala

20 25 30Lys Ala Leu Ala Ala Gly Ala Asn Ser Val Met Leu Gly Ser Met Leu

35 40 45Ala Gly Thr Ala Glu Ala Pro Gly Glu Thr Ile Thr Ile Asn Gly Lys

50 55 60Gln Tyr Lys Arg Tyr Arg Gly Met Gly Ser Met Gly Ala Met Gln Gly 65 70 75 80Arg Gly Leu Ser Gly Glu Lys Arg Ser Tyr Ser Lys Asp Arg Tyr Phe

85 90 95Gln Ser Asp Val Lys Ser Glu Asp Lys Leu Val Pro Glu Gly Ile Glu

100 105 110Gly Arg Val Pro Phe Arg Gly Pro Ile Gly Asp Ile Ile His Gln Gln

115 120 125Val Gly Gly Leu Arg Ala Ala Met Gly Tyr Thr Gly Ser Ser Thr Ile

130 135 140Glu Glu Leu His Asn Ala Arg Phe Val Gln Ile Thr Ser Ala Gly Leu145 150 155 160Lys Glu Ser His Pro His His Ile Gln Gln Thr Val Glu Ala Pro Asn

165170175 Tyr His<210>951<211>1554<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1531)<223>RXA02469<400>951cgtcgaaaag cagtagtaaa gcagcaggaa ggtggtggaa agagcaattg aggtaccctt 60gccgtgttca gggataactg attaatcaac taggagaccc atg cgt ttt ctt aac 115

Met Arg Phe Leu Asn

1 5aat tcc aat ccg ccc tat gag ctg aca tat tcc gat gtg ttt atg gtg 163Asn Ser Asn Pro Pro Tyr Glu Leu Thr Tyr Ser Asp Val Phe Met Val

10 15 20cct tcg cgt tct gac gta ggc tcc cgc atg tcc gtg gat ctg cgc acc 211Pro Ser Arg Ser Asp Val Gly Ser Arg Met Ser Val Asp Leu Arg Thr

25 30 35aat gac gga act gga aca acc atc ccg ctc gtt gtg gca aac atg act 259Asn Asp Gly Thr Gly Thr Thr Ile Pro Leu Val Val Ala Asn Met Thr

40 45 50gct gtt gct ggc cga cgc atg gct gag acc att gcg cgc cgc ggt ggc 307Ala Val Ala Gly Arg Arg Met Ala Glu Thr Ile Ala Arg Arg Gly Gly

55 60 65atg gcg att ctt ccg cag gat gtg ccc gcc gat att gct gca gag act 355Met Ala Ile Leu Pro Gln Asp Val Pro Ala Asp Ile Ala Ala Glu Thr 70 75 80 85atc gcg aat gtg aag aaa gcg gac ctg gtt ttt gat acc cca att acc 403Ile Ala Asn Val Lys Lys Ala Asp Leu Val Phe Asp Thr Pro Ile Thr

90 95 100gta aaa ccg cac cac acc gtg ggt tat gca cgc aac ttg atc cac aag 451Val Lys Pro His His Thr Val Gly Tyr Ala Arg Asn Leu Ile His Lys

105 110 115cgt gcg cac ggt gca gcc att gtt ttg gag ggc gat cag ccg gtc ggc 499Arg Ala His Gly Ala Ala Ile Val Leu Glu Gly Asp Gln Pro Val Gly

120 125 130atc gtc acc gac aag gac ctc gaa ggc gca gac aac ttc act cag gtg 547Ile Val Thr Asp Lys Asp Leu Glu Gly Ala Asp Asn Phe Thr Gln Val

135 140 145ggc acc ctc atg tcc acc tcc cta ttg acg ctg cct gag gat att tcc 595Gly Thr Leu Met Ser Thr Ser Leu Leu Thr Leu Pro Glu Asp Ile Ser150 155 160 165ccc gaa gac gcc ttc gga atc ctc cac gaa cac agc cgc aaa ctc gcc 643Pro Glu Asp Ala Phe Gly Ile Leu His Glu His Ser Arg Lys Leu Ala

170 175 180ccc gtc gtc gcg gct gac ggc tca ctc cgc ggc atc ctc acc cgc acc 691Pro Val Val Ala Ala Asp Gly Ser Leu Arg Gly Ile Leu Thr Arg Thr

185 190 195ggc gcc ctg cgc gcc acc atg tac aag ccg gct atc gac gcc aac ggc 739Gly Ala Leu Arg Ala Thr Met Tyr Lys Pro Ala Ile Asp Ala Asn Gly

200 205 210cgc ctg cga gtc ggc gcc gcc atc ggc atc aac ggc gac atc gaa gga 787Arg Leu Arg Val Gly Ala Ala Ile Gly Ile Asn Gly Asp Ile Glu Gly

215 220 225cgc acc aaa acg ctt ctc gac gcc ggc gcc gac gtt cta gtc gtc gac 835Arg Thr Lys Thr Leu Leu Asp Ala Gly Ala Asp Val Leu Val Val Asp230 235 240 245aca gca cac ggc cac caa tcc acc atg atc agc gcc ctc aaa cgc atc 883Thr Ala His Gly His Gln Ser Thr Met Ile Ser Ala Leu Lys Arg Ile

250 255 260cgc gca ctc gac gtc aac gtc ccc atc gtt gct ggc aac gtg gtc acc 931Arg Ala Leu Asp Val Asn Val Pro Ile Val Ala Gly Asn Val Val Thr

265 270 275gcc gat ggt gtc cgc gac cta gtt gaa gca ggc gca aac atc atc aag 979Ala Asp Gly Val Arg Asp Leu Val Glu Ala Gly Ala Asn Ile Ile Lys

280 285 290gta ggc gtt gga cca ggc gca atg tgc acc acc cgc atg caa acc ggc 1027Val Gly Val Gly Pro Gly Ala Met Cys Thr Thr Arg Met Gln Thr Gly

295 300 305gtt ggc cga cca cag ttc tcc gca gtg ctg gaa tgc gca gcc gaa gcc 1075Val Gly Arg Pro Gln Phe Ser Ala Val Leu Glu Cys Ala Ala Glu Ala310 315 320 325cgc aaa ctc ggc gca cac gta tgg gca gac ggc gga gtc cgc gac ccc 1123Arg Lys Leu Gly Ala His Val Trp Ala Asp Gly Gly Val Arg Asp Pro

330 335 340cgc gac gtc gcc ctg gca ctc gca gct ggc gcc tcc aac gtg atg gtc 1171Arg Asp Val Ala Leu Ala Leu Ala Ala Gly Ala Ser Asn Val Met Val

345 350 355gga tcc tgg ttc tcc gga acc tac gaa tcc ccc ggc gac ctc cgc ttc 1219Gly Ser Trp Phe Ser Gly Thr Tyr Glu Ser Pro Gly Asp Leu Arg Phe

360 365 370gaa tcc gac gga cgc atg tac aaa gaa tcc ttc ggt atg gca tcc cgg 1267Glu Ser Asp Gly Arg Met Tyr Lys Glu Ser Phe Gly Met Ala Ser Arg

375 380 385cgc gcc gtg gaa agc cga aac caa aag gtc gaa gct ttc gaa aaa gca 1315Arg Ala Val Glu Ser Arg Asn Gln Lys Val Glu Ala Phe Glu Lys Ala390 395 400 405cgc cgc gca atg ttc gaa gaa ggc atc tcc act gcc cgc atc tac att 1363Arg Arg Ala Met Phe Glu Glu Gly Ile Ser Thr Ala Arg Ile Tyr Ile

410 415 420gac aaa cgc cac ggc gga gtc gag gac ctg gta gat caa atc atc tcc 1411Asp Lys Arg His Gly Gly Val Glu Asp Leu Val Asp Gln Ile Ile Ser

425 430 435ggt gtc cgc tcc tca ttc acc tac gca ggc gcc gat tcg att gaa acc 1459Gly Val Arg Ser Ser Phe Thr Tyr Ala Gly Ala Asp Ser Ile Glu Thr

440 445 450ttc ttc gaa cgc gcc acc gtc gga gtt caa tcc acc gaa ggc tac gca 1507Phe Phe Glu Arg Ala Thr Val Gly Val Gln Ser Thr Glu Gly Tyr Ala

455460465 gaa gga aag cca cgc gct tcg cgt taagtgttgt tgtgcctttg aga 1554Glu Gly Lys Pro Arg Ala Ser Arg 470475<210>952<211>477<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>952Met Arg Phe Leu Asn Asn Ser Asn Pro Pro Tyr Glu Leu Thr Tyr Ser 151015 Asp Val Phe Met Val Pro Ser Arg Ser Asp Val Gly Ser Arg Met Ser

20 25 30Val Asp Leu Arg Thr Asn Asp Gly Thr Gly Thr Thr Ile Pro Leu Val

35 4045Val Ala Asn Met Thr Ala Val Ala Gly Arg Arg Met Ala Glu Thr Ile

50 55 60Ala Arg Arg Gly Gly Met Ala Ile Leu Pro Gln Asp Val Pro Ala Asp 65 70 75 80Ile Ala Ala Glu Thr Ile Ala Asn Val Lys Lys Ala Asp Leu Val Phe

85 90 95Asp Thr Pro Ile Thr Val Lys Pro His His Thr Val Gly Tyr Ala Arg

100 105 110Asn Leu Ile His Lys Arg Ala His Gly Ala Ala Ile Val Leu Glu Gly

115 120 125Asp Gln Pro Val Gly Ile Val Thr Asp Lys Asp Leu Glu Gly Ala Asp

130 135 140Asn Phe Thr Gln Val Gly Thr Leu Met Ser Thr Ser Leu Leu Thr Leu145 150 155 160Pro Glu Asp Ile Ser Pro Glu Asp Ala Phe Gly Ile Leu His Glu His

165 170 175Ser Arg Lys Leu Ala Pro Val Val Ala Ala Asp Gly Ser Leu Arg Gly

180 185 190Ile Leu Thr Arg Thr Gly Ala Leu Arg Ala Thr Met Tyr Lys Pro Ala

195 200 205 Ile Asp Ala Asn Gly Arg Leu Arg Val Gly Ala Ala Ile Gly Ile Asn

210 215 220Gly Asp Ile Glu Gly Arg Thr Lys Thr Leu Leu Asp Ala Gly Ala Asp225 230 235 240Val Leu Val Val Asp Thr Ala His Gly His Gln Ser Thr Met Ile Ser

245 250 255Ala Leu Lys Arg Ile Arg Ala Leu Asp Val Asn Val Pro Ile Val Ala

260265 270 Gly Asn Val Val Thr Ala Asp Gly Val Arg Asp Leu Val Glu Ala Gly

275 280 285Ala Asn Ile Ile Lys Val Gly Val Gly Pro Gly Ala Met Cys Thr Thr

290 295 300Arg Met Gln Thr Gly Val Gly Arg Pro Gln Phe Ser Ala Val Leu Glu305 310 315 320Cys Ala Ala Glu Ala Arg Lys Leu Gly Ala His Val Trp Ala Asp Gly

325 330 335Gly Val Arg Asp Pro Arg Asp Val Ala Leu Ala Leu Ala Ala Gly Ala

340 345 350Ser Asn Val Met Val Gly Ser Trp Phe Ser Gly Thr Tyr Glu Ser Pro

355 360 365Gly Asp Leu Arg Phe Glu Ser Asp Gly Arg Met Tyr Lys Glu Ser Phe

370 375 380Gly Met Ala Ser Arg Arg Ala Val Glu Ser Arg Asn Gln Lys Val Glu385 390 395 400Ala Phe Glu Lys Ala Arg Arg Ala Met Phe Glu Glu Gly Ile Ser Thr

405 410 415Ala Arg Ile Tyr Ile Asp Lys Arg His Gly Gly Val Glu Asp Leu Val

420 425 430Asp Gln Ile Ile Ser Gly Val Arg Ser Ser Phe Thr Tyr Ala Gly Ala

435 440 445Asp Ser Ile Glu Thr Phe Phe Glu Arg Ala Thr Val Gly Val Gln Ser

450455460 Thr Glu Gly Tyr Ala Glu Gly Lys Pro Arg Ala Ser Arg 465470A 75<210>953<211>1692<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).)

Val Ser Leu Gln Thr

1 5aat cat cgc cca gta ctc gtc gtt gac ttc ggc gca cag tac gcg cag 163Asn His Arg Pro Val Leu Val Val Asp Phe Gly Ala Gln Tyr Ala Gln

10 15 20ctg atc gca cgt cgt gtg cgt gag gcc ggc atc tac tcc gaa gtc atc 211Leu Ile Ala Arg Arg Val Arg Glu Ala Gly Ile Tyr Ser Glu Val Ile

25 30 35ccg cac acc gcc acc gca gac gat gtg cgc gct aaa aat gca gca gcc 259Pro His Thr Ala Thr Ala Asp Asp Val Arg Ala Lys Asn Ala Ala Ala

40 45 50ctc gtc ctt tcc ggt ggc cca tcc tcc gtg tat gcc gag gga gca cca 307Leu Val Leu Ser Gly Gly Pro Ser Ser Val Tyr Ala Glu Gly Ala Pro

55 60 65tcc ctt gac gct gag att ctt gat ctc gga ttg cca gta ttt ggc att 355Ser Leu Asp Ala Glu Ile Leu Asp Leu Gly Leu Pro Val Phe Gly Ile 70 75 80 85tgc tac ggc ttc caa gcc atg acc cac gcg ctt ggt ggc acc gtt gcc 403Cys Tyr Gly Phe Gln Ala Met Thr His Ala Leu Gly Gly Thr Val Ala

90 95 100aac acc ggt aag cgc gaa tac gga cgc acc gac atc aac gtt gcc ggt 451Asn Thr Gly Lys Arg Glu Tyr Gly Arg Thr Asp Ile Asn Val Ala Gly

105 110 115ggc gtc ctc cac gaa ggc ctc gaa gcc tgc cac aag gtg tgg atg agc 499Gly Val Leu His Glu Gly Leu Glu Ala Cys His Lys Val Trp Met Ser

120 125 130cac ggc gac gcc gtc tct gaa gcc cca gaa ggt ttc gta gtc acc gcg 547His Gly Asp Ala Val Ser Glu Ala Pro Glu Gly Phe Val Val Thr Ala

135 140 145tcc tcc gaa ggt gcg cct gtc gca gct ttc gaa aac aag gaa cgc aaa 595Ser Ser Glu Gly Ala Pro Val Ala Ala Phe Glu Asn Lys Glu Arg Lys150 155 160 165atg gct ggc gtg cag tac cac cca gag gta ttg cac tca cca cac ggc 643Met Ala Gly Val Gln Tyr His Pro Glu Val Leu His Ser Pro His Gly

170 175 180cag gca gtt ctg acc cgc ttc ctc act gag atc gca ggt cta gag cag 691Gln Ala Val Leu Thr Arg Phe Leu Thr Glu Ile Ala Gly Leu Glu Gln

185 190 195aac tgg acc gca gca aac atc gct gaa gaa ctc atc gaa aag gtc cgc 739Asn Trp Thr Ala Ala Asn Ile Ala Glu Glu Leu Ile Glu Lys Val Arg

200 205 210gag cag atc ggc gaa gat ggc cgc gct att tgt ggc cta tcc ggt ggt 787Glu Gln Ile Gly Glu Asp Gly Arg Ala Ile Cys Gly Leu Ser Gly Gly

215 220 225gtg gac tcc gct gtt gcc ggt gct ttg gtg cag cgc gcc att ggt gac 835Val Asp Ser Ala Val Ala Gly Ala Leu Val Gln Arg Ala Ile Gly Asp230 235 240 245cgt ttg acc tgt gtc ttt gtt gac cac ggt ctg ctg cgt gcc ggt gag 883Arg Leu Thr Cys Val Phe Val Asp His Gly Leu Leu Arg Ala Gly Glu

250 255 260cgc gag cag gtg gaa aaa gac ttc gtc gca gca acc ggc gcc aag ctg 931Arg Glu Gln Val Glu Lys Asp Phe Val Ala Ala Thr Gly Ala Lys Leu

265 270 275gtt acc gtt gat gag cgc cag gca ttc cta tcc aag ctg gcc gga gtt 979Val Thr Val Asp Glu Arg Gln Ala Phe Leu Ser Lys Leu Ala Gly Val

280 285 290acc gaa cca gaa gca aag cgc aag gct atc ggc gct gag ttc atc cgc 1027Thr Glu Pro Glu Ala Lys Arg Lys Ala Ile Gly Ala Glu Phe Ile Arg

295 300 305tcc ttc gag cgc gca gtt gcc ggt gtg ctg gaa gaa gct cca gaa ggt 1075Ser Phe Glu Arg Ala Val Ala Gly Val Leu Glu Glu Ala Pro Glu Gly310 315 320 325tcc acc gtg gac ttc ctg gtt cag ggc acc ctg tac cca gac gtc gtg 1123Ser Thr Val Asp Phe Leu Val Gln Gly Thr Leu Tyr Pro Asp Val Val

330 335 340gaa tcc ggt ggt gga tct ggt acc gca aac atc aag agc cac cac aac 1171Glu Ser Gly Gly Gly Ser Gly Thr Ala Asn Ile Lys Ser His His Asn

345 350 355gtc ggt gga ctg cca gac gat gtg gaa ttc aag ctt gtt gag cca ctg 1219Val Gly Gly Leu Pro Asp Asp Val Glu Phe Lys Leu Val Glu Pro Leu

360 365 370cgt gac ctc ttc aaa gac gaa gtc cgt gcc gtt ggc cgt gaa ctt ggc 1267Arg Asp Leu Phe Lys Asp Glu Val Arg Ala Val Gly Arg Glu Leu Gly

375 380 385ctg cct gag gaa atc gtt ggc cgc cag cca ttc cca gga cca gga ctt 1315Leu Pro Glu Glu Ile Val Gly Arg Gln Pro Phe Pro Gly Pro Gly Leu390 395 400 405ggt atc cgc atc atc ggt gaa gtc acc gaa gat cgc cta gaa acc ctc 1363Gly Ile Arg Ile Ile Gly Glu Val Thr Glu Asp Arg Leu Glu Thr Leu

410 415 420cgc cac gct gac ctg atc gcc cgc acc gag ctc acc gaa gcc gga ctt 1411Arg His Ala Asp Leu Ile Ala Arg Thr Glu Leu Thr Glu Ala Gly Leu

425 430 435gac ggc gtg atc tgg cag tgc cca gta gtc ctc ctg gca gat gtc cgc 1459Asp Gly Val Ile Trp Gln Cys Pro Val Val Leu Leu Ala AspVal Arg

440 445 450tct gtt ggt gtt caa ggc gat ggc cgc acc tac gga cac cca atc gtg 1507Ser Val Gly Val Gln Gly Asp Gly Arg Thr Tyr Gly His Pro Ile Val

455 460 465ctg cgc cca gtg tct tcc gaa gac gca atg acc gcc gac tgg acc cgc 1555Leu Arg Pro Val Ser Ser Glu Asp Ala Met Thr Ala Asp Trp Thr Arg470 475 480 485ctg cca tac gag gtt ctg gag aag atc tcc acc cgc atc acc aac gaa 1603Leu Pro Tyr Glu Val Leu Glu Lys Ile Ser Thr Arg Ile Thr Asn Glu

490 495 500gtt cca gat gtg aac cgc gtg gtg ctg gac gta acc tcc aag cca cca 1651Val Pro Asp Val Asn Arg Val Val Leu Asp Val Thr Ser Lys Pro Pro

505 510 515gga acc atc gaa tgg gag taggccttaa atgagccttc gtt 1692Gly Thr Ile Glu Trp Glu

520<210>954<211>523<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>954Val Ser Leu Gln Thr Asn His Arg Pro Val Leu Val Val Asp Phe Gly 151015 Ala Gln Tyr Ala Gln Leu Ile Ala Arg Arg Val Arg Glu Ala Gly Ile

20 25 30Tyr Ser Glu Val Ile Pro His Thr Ala Thr Ala Asp Asp Val Arg Ala

35 40 45Lys Asn Ala Ala Ala Leu Val Leu Ser Gly Gly Pro Ser Ser Val Tyr

50 55 60 Ala Glu Gly Ala Pro Ser Leu Asp Ala Glu Ile Leu Asp Leu Gly Leu65 70 75 80Pro Val Phe Gly Ile Cys Tyr Gly Phe Gln Ala Met Thr His Ala Leu

85 90 95Gly Gly Thr Val Ala Asn Thr Gly Lys Arg Glu Tyr Gly Arg Thr Asp

100 105 110Ile Asn Val Ala Gly Gly Val Leu His Glu Gly Leu Glu Ala Cys His

115 120 125Lys Val Trp Met Ser His Gly Asp Ala Val Ser Glu Ala Pro Glu Gly

130 135 140Phe Val Val Thr Ala Ser Ser Glu Gly Ala Pro Val Ala Ala Phe Glu145 150 155 160Asn Lys Glu Arg Lys Met Ala Gly Val Gln Tyr His Pro Glu Val Leu

165 170 175His Ser Pro His Gly Gln Ala Val Leu Thr Arg Phe Leu Thr Glu Ile

180 185 190Ala Gly Leu Glu Gln Asn Trp Thr Ala Ala Asn Ile Ala Glu Glu Leu

195 200 205Ile Glu Lys Val Arg Glu Gln Ile Gly Glu Asp Gly Arg Ala Ile Cys

210 215 220Gly Leu Ser Gly Gly Val Asp Ser Ala Val Ala Gly Ala Leu Val Gln225 230 235 240Arg Ala Ile Gly Asp Arg Leu Thr Cys Val Phe Val Asp His Gly Leu

245 250 255Leu Arg Ala Gly Glu Arg Glu Gln Val Glu Lys Asp Phe Val Ala Ala

260 265 270Thr Gly Ala Lys Leu Val Thr Val Asp Glu Arg Gln Ala Phe Leu Ser

275 280 285Lys Leu Ala Gly Val Thr Glu Pro Glu Ala Lys Arg Lys Ala Ile Gly

290 295 300Ala Glu Phe Ile Arg Ser Phe Glu Arg Ala Val Ala Gly Val Leu Glu305 310 315 320Glu Ala Pro Glu Gly Ser Thr Val Asp Phe Leu Val Gln Gly Thr Leu

325 330 335Tyr Pro Asp Val Val Glu Ser Gly Gly Gly Ser Gly Thr Ala Asn Ile

340 345 350Lys Ser His His Asn Val Gly Gly Leu Pro Asp Asp Val Glu Phe Lys

355 360 365Leu Val Glu Pro Leu Arg Asp Leu Phe Lys Asp Glu Val Arg Ala Val

370 375 380Gly Arg Glu Leu Gly Leu Pro Glu Glu Ile Val Gly Arg Gln Pro Phe385 390 395 400Pro Gly Pro Gly Leu Gly Ile Arg Ile Ile Gly Glu Val Thr Glu Asp

405 410 415Arg Leu Glu Thr Leu Arg His Ala Asp Leu Ile Ala Arg Thr Glu Leu

420 425 430Thr Glu Ala Gly Leu Asp Gly Val Ile Trp Gln Cys Pro Val Val Leu

435 440 445Leu Ala Asp Val Arg Ser Val Gly Val Gln Gly Asp Gly Arg Thr Tyr

450 455 460Gly His Pro Ile Val Leu Arg Pro Val Ser Ser Glu Asp Ala Met Thr465 470 475 480Ala Asp Trp Thr Arg Leu Pro Tyr Glu Val Leu Glu Lys Ile Ser Thr

485 490 495Arg Ile Thr Asn Glu Val Pro Asp Val Asn Arg Val Val Leu Asp Val

500 505 510Thr Ser Lys Pro Pro Gly Thr Ile Glu Trp Glu

515520<210>955<211>1486<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1486)<223>FRXA00487<400>955agggcgccag gggcatccag ccattaaagc ttttcgacga gccctcgccc atgtggccaa 60agaatcttat ttggaggctc gtctagtaga gtgagttctt gtg agc ctt cag aca 115

Val Ser Leu Gln Thr

1 5aat cat cgc cca gta ctc gtc gtt gac ttc ggc gca cag tac gcg cag 163Asn His Arg Pro Val Leu Val Val Asp Phe Gly Ala Gln Tyr Ala Gln

10 15 20ctg atc gca cgt cgt gtg cgt gag gcc ggc atc tac tcc gaa gtc atc 211Leu Ile Ala Arg Arg Val Arg Glu Ala Gly Ile Tyr Ser Glu Val Ile

25 30 35ccg cac acc gcc acc gca gac gat gtg cgc gct aaa aat gca gca gcc 259Pro His Thr Ala Thr Ala Asp Asp Val Arg Ala Lys Asn Ala Ala Ala

40 45 50ctc gtc ctt tcc ggt ggc cca tcc tcc gtg tat gcc gag gga gca cca 307Leu Val Leu Ser Gly Gly Pro Ser Ser Val Tyr Ala Glu Gly Ala Pro

55 60 65tcc ctt gac gct gag att ctt gat ctc gga ttg cca gta ttt ggc att 355Ser Leu Asp Ala Glu Ile Leu Asp Leu Gly Leu Pro Val Phe Gly Ile 70 75 80 85tgc tac ggc ttc caa gcc atg acc cac gcg ctt ggt ggc acc gtt gcc 403Cys Tyr Gly Phe Gln Ala Met Thr His Ala Leu Gly Gly Thr Val Ala

90 95 100aac acc ggt aag cgc gaa tac gga cgc acc gac atc aac gtt gcc ggt 451Asn Thr Gly Lys Arg Glu Tyr Gly Arg Thr Asp Ile Asn Val Ala Gly

105 110 115ggc gtc ctc cac gaa ggc ctc gaa gcc tgc cac aag gtg tgg atg agc 499Gly Val Leu His Glu Gly Leu Glu Ala Cys His Lys Val Trp Met Ser

120 125 130cac ggc gac gcc gtc tct gaa gcc cca gaa ggt ttc gta gtc acc gcg 547His Gly Asp Ala Val Ser Glu Ala Pro Glu Gly Phe Val Val Thr Ala

135 140 145tcc tcc gaa ggt gcg cct gtc gca gct ttc gaa aac aag gaa cgc aaa 595Ser Ser Glu Gly Ala Pro Val Ala Ala Phe Glu Asn Lys Glu Arg Lys150 155 160 165atg gct ggc gtg cag tac cac cca gag gta ttg cac tca cca cac ggc 643Met Ala Gly Val Gln Tyr His Pro Glu Val Leu His Ser Pro His Gly

170 175 180cag gca gtt ctg acc cgc ttc ctc act gag atc gca ggt cta gag cag 691Gln Ala Val Leu Thr Arg Phe Leu Thr Glu Ile Ala Gly Leu Glu Gln

185 190 195aac tgg acc gca gca aac atc gct gaa gaa ctc atc gaa aag gtc cgc 739Asn Trp Thr Ala Ala Asn Ile Ala Glu Glu Leu Ile Glu Lys Val Arg

200 205 210gag cag atc ggc gaa gat ggc cgc gct att tgt ggc cta tcc ggt ggt 787Glu Gln Ile Gly Glu Asp Gly Arg Ala Ile Cys Gly Leu Ser Gly Gly

215 220 225gtg gac tcc gct gtt gcc ggt gct ttg gtg cag cgc gcc att ggt gac 835Val Asp Ser Ala Val Ala Gly Ala Leu Val Gln Arg Ala Ile Gly Asp230 235 240 245cgt ttg acc tgt gtc ttt gtt gac cac ggt ctg ctg cgt gcc ggt gag 883Arg Leu Thr Cys Val Phe Val Asp His Gly Leu Leu Arg Ala Gly Glu

250 255 260cgc gag cag gtg gaa aaa gac ttc gtc gca gca acc ggc gcc aag ctg 931Arg Glu Gln Val Glu Lys Asp Phe Val Ala Ala Thr Gly Ala Lys Leu

265 270 275gtt acc gtt gat gag cgc cag gca ttc cta tcc aag ctg gcc gga gtt979Val Thr Val Asp Glu Arg Gln Ala Phe Leu Ser Lys Leu Ala Gly Val

280 285 290acc gaa cca gaa gca aag cgc aag gct atc ggc gct gag ttc atc cgc 1027Thr Glu Pro Glu Ala Lys Arg Lys Ala Ile Gly Ala Glu Phe Ile Arg

295 300 305tcc ttc gag cgc gca gtt gcc ggt gtg ctg gaa gaa gct cca gaa ggt 1075Ser Phe Glu Arg Ala Val Ala Gly Val Leu Glu Glu Ala Pro Glu Gly310 315 320 325tcc acc gtg gac ttc ctg gtt cag ggc acc ctg tac cca gac gtc gtg 1123Ser Thr Val Asp Phe Leu Val Gln Gly Thr Leu Tyr Pro Asp Val Val

330 335 340gaa tcc ggt ggt gga tct ggt acc gca aac atc aag agc cac cac aac 1171Glu Ser Gly Gly Gly Ser Gly Thr Ala Asn Ile Lys Ser His His Asn

345 350 355 gtc ggt gga ctg cca gac gat gtg gaa ttc aag ctt gtt gag cca ctg 1219Val Gly Gly Leu Pro Asp Asp Val Glu Phe Lys Leu Val Glu Pro Leu

360 365 370cgt gac ctc ttc aaa gac gaa gtc cgt gcc gtt ggc cgt gaa ctt ggc 1267Arg Asp Leu Phe Lys Asp Glu Val Arg Ala Val Gly Arg Glu Leu Gly

375 380 385ctg cct gag gaa atc gtt ggc cgc cag cca ttc cca gga cca gga ctt 1315Leu Pro Glu Glu Ile Val Gly Arg Gln Pro Phe Pro Gly Pro Gly Leu390 395 400 405ggt atc cgc atc atc ggt gaa gtc acc gaa gat cgc cta gaa acc ctc 1363Gly Ile Arg Ile Ile Gly Glu Val Thr Glu Asp Arg Leu Glu Thr Leu

410 415 420cgc cac gct gac ctg atc gcc cgc acc gag ctc acc gaa gcc gga ctt 1411Arg His Ala Asp Leu Ile Ala Arg Thr Glu Leu Thr Glu Ala Gly Leu

425 430 435gac ggc gtg atc tgg cag tgc cca gta gtc ctc ctg gca gat gtc cgc 1459Asp Gly Val Ile Trp Gln Cys Pro Val Val Leu Leu Ala Asp Val Arg

440 445 450tct gtt ggt gtt caa ggc gat ggc cgc 1486Ser Val Gly Val Gln Gly Asp Gly Arg

455460<210>956<211>462<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>956Val Ser Leu Gln Thr Asn His Arg Pro Val Leu Val Val Asp Phe Gly 151015 Ala Gln Tyr Ala Gln Leu Ile Ala Arg Arg Val Arg Glu Ala Gly Ile

20 25 30Tyr Ser Glu Val Ile Pro His Thr Ala Thr Ala Asp Asp Val Arg Ala

35 40 45Lys Asn Ala Ala Ala Leu Val Leu Ser Gly Gly Pro Ser Ser Val Tyr

50 55 60Ala Glu Gly Ala Pro Ser Leu Asp Ala Glu Ile Leu Asp Leu Gly Leu 65 70 75 80Pro Val Phe Gly Ile Cys Tyr Gly Phe Gln Ala Met Thr His Ala Leu

85 90 95Gly Gly Thr Val Ala Asn Thr Gly Lys Arg Glu Tyr Gly Arg Thr Asp

100 105 110Ile Asn Val Ala Gly Gly Val Leu His Glu Gly Leu Glu Ala Cys His

115 120 125Lys Val Trp Met Ser His Gly Asp Ala Val Ser Glu Ala Pro Glu Gly

130 135 140Phe Val Val Thr Ala Ser Ser Glu Gly Ala Pro Val Ala Ala Phe Glu145 150 155 160Asn Lys Glu Arg Lys Met Ala Gly Val Gln Tyr His Pro Glu Val Leu

165 170 175His Ser Pro His Gly Gln Ala Val Leu Thr Arg Phe Leu Thr Glu Ile

180 185 190Ala Gly Leu Glu Gln Asn Trp Thr Ala Ala Asn Ile Ala Glu Glu Leu

195 200 205Ile Glu Lys Val Arg Glu Gln Ile Gly Glu Asp Gly Arg Ala Ile Cys

210 215 220Gly Leu Ser Gly Gly Val Asp Ser Ala Val Ala Gly Ala Leu Val Gln225 230 235 240Arg Ala Ile Gly Asp Arg Leu Thr Cys Val Phe Val Asp His Gly Leu

245 250 255Leu Arg Ala Gly Glu Arg Glu Gln Val Glu Lys Asp Phe Val Ala Ala

260 265 270Thr Gly Ala Lys Leu Val Thr Val Asp Glu Arg Gln Ala Phe Leu Ser

275 280 285Lys Leu Ala Gly Val Thr Glu Pro Glu Ala Lys Arg Lys Ala Ile Gly

290 295 300Ala Glu Phe Ile Arg Ser Phe Glu Arg Ala Val Ala Gly Val Leu Glu305 310 315 320Glu Ala Pro Glu Gly Ser Thr Val Asp Phe Leu Val Gln Gly Thr Leu

325 330 335Tyr Pro Asp Val Val Glu Ser Gly Gly Gly Ser Gly Thr Ala Asn Ile

340 345 350Lys Ser His His Asn Val Gly Gly Leu Pro Asp Asp Val Glu Phe Lys

355 360 365Leu Val Glu Pro Leu Arg Asp Leu Phe Lys Asp Glu Val Arg Ala Val

370 375 380Gly Arg Glu Leu Gly Leu Pro Glu Glu Ile Val Gly Arg GlnPro Phe385 390 395 400Pro Gly Pro Gly Leu Gly Ile Arg Ile Ile Gly Glu Val Thr Glu Asp

405 410 415Arg Leu Glu Thr Leu Arg His Ala Asp Leu Ile Ala Arg Thr Glu Leu

420 425 430Thr Glu Ala Gly Leu Asp Gly Val Ile Trp Gln Cys Pro Val Val Leu

435 440 445Leu Ala Asp Val Arg Ser Val Gly Val Gln Gly Asp Gly Arg

450455460<210>957<211>693<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<670><223>RXA02237<400>957gacgagctgg gcattgctca gacccgtcgt cttcgtggac tgggtgaccg tcagcgtcgc 60gcacttctcg agcgtttcgg cttcgaggat taattcttca gtg tcg ggc gat aac 115

Val Ser Gly Asp Asn

1 5caa cta gga cgg ctc gta att ctt gcg ggc ccc tca gcg gtc ggt aaa 163Gln Leu Gly Arg Leu Val Ile Leu Ala Gly Pro Ser Ala Val Gly Lys

10 15 20tcg act gtg gtt gat cgc ctc cgc aat gac gtt cca aac ctg tat ttc 211Ser Thr Val Val Asp Arg Leu Arg Asn Asp Val Pro Asn Leu Tyr Phe

25 30 35agt gtg tcg atg acc act agg gca cct cgt cct ggt gaa gtc gat gga 259Ser Val Ser Met Thr Thr Arg Ala Pro Arg Pro Gly Glu Val Asp Gly

40 45 50cgt gac tac ttc tat gtc act gca cag gaa ttt cag gac aaa atc gac 307Arg Asp Tyr Phe Tyr Val Thr Ala Gln Glu Phe Gln Asp Lys Ile Asp

55 6065tgt gga gag atg ctt gaa tgg gca gat atc cac ggc ggt ttg cag cgt 355Cys Gly Glu Met Leu Glu Trp Ala Asp Ile His Gly Gly Leu Gln Arg 70 75 80 85tca ggc act cca gca ggt ccc gtc aat gag gct cgc caa aat ggt cgg 403Ser Gly Thr Pro Ala Gly Pro Val Asn Glu Ala Arg Gln Asn Gly Arg

90 95 100cca gta ttg gtt gag gtt gat ctt gca gga gcc cga aac atc gct agc 451Pro Val Leu Val Glu Val Asp Leu Ala Gly Ala Arg Asn Ile Ala Ser

105 110 115tta att cca gat gca gaa acc atc ttc ctt gct cca cct tca tgg gaa 499Leu Ile Pro Asp Ala Glu Thr Ile Phe Leu Ala Pro Pro Ser Trp Glu

120 125 130gtt ttg gtt gaa cgc ctc act gga cgt ggc acc gaa agc gaa gac gtt 547Val Leu Val Glu Arg Leu Thr Gly Arg Gly Thr Glu Ser Glu Asp Val

135 140 145att gct cgc agg ctc gag acc gca cgc gaa gaa ttg gct gct cag agc 595Ile Ala Arg Arg Leu Glu Thr Ala Arg Glu Glu Leu Ala Ala Gln Ser150 155 160 165gaa ttt aag cac gtc att atc aat gat gat gtg gat aca gcc gtc aag 643Glu Phe Lys His Val Ile Ile Asn Asp Asp Val Asp Thr Ala Val Lys

170 175 180gct att gag gat gtt ctc ctc ggc gct tagccaaaac atagagcggt 690Ala Ile Glu Asp Val Leu Leu Gly Ala

185190 agg 693<210>958<211>190<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>958Val Ser Gly Asp Asn Gln Leu Gly Arg Leu Val Ile Leu Ala Gly Pro 151015 Ser Ala Val Gly Lys Ser Thr Val Val Asp Arg Leu Arg Asn Asp Val

20 25 30Pro AsnLeu Tyr Phe Ser Val Ser Met Thr Thr Arg Ala Pro Arg Pro

35 40 45Gly Glu Val Asp Gly Arg Asp Tyr Phe Tyr Val Thr Ala Gln Glu Phe

50 55 60Gln Asp Lys Ile Asp Cys Gly Glu Met Leu Glu Trp Ala Asp Ile His 65 70 75 80 Gly Gly Leu Gln Arg Ser Gly Thr Pro Ala Gly Pro Val Asn Glu Ala

85 90 95Arg Gln Asn Gly Arg Pro Val Leu Val Glu Val Asp Leu Ala Gly Ala

100 105 110Arg Asn Ile Ala Ser Leu Ile Pro Asp Ala Glu Thr Ile Phe Leu Ala

115 120 125Pro Pro Ser Trp Glu Val Leu Val Glu Arg Leu Thr Gly Arg Gly Thr

130 135 140Glu Ser Glu Asp Val Ile Ala Arg Arg Leu Glu Thr Ala Arg Glu Glu145 150 155 160Leu Ala Ala Gln Ser Glu Phe Lys His Val Ile Ile Asn Asp Asp Val

165 170 175Asp Thr Ala Val Lys Ala Ile Glu Asp Val Leu Leu Gly Ala

180185190<210>959<211>1413<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<1390)<223>RXA01446<400>959gatgattaaa aacctcacat gggatagtaa gatgaaataa cgtctgtgtg cgcacacgcg 60tgcatactcc aacttcatgg atcggatgtg acgtaaacca atg gct gca atc gtt 115

Met Ala Ala Ile Val

1 5att gtc ggc gct caa tgg ggc gat gaa ggc aaa ggt aag gcc acg gat 163Ile Val Gly Ala Gln Trp Gly Asp Glu Gly Lys Gly Lys Ala Thr Asp

10 15 20att ctc ggc gga ctc gtc gat tac gtg gtt aag ccc aat ggc ggt aac 211Ile Leu Gly Gly Leu Val Asp Tyr Val Val Lys Pro Asn Gly Gly Asn

25 30 35aac gct gga cac act gtt gtg gtc ggc ggc gag aag tac gag cta aag 259Asn Ala Gly His Thr Val Val Val Gly Gly Glu Lys Tyr Glu Leu Lys

40 45 50ctc ctt cct gcc ggc gtc ctc tcc gaa acg gcc acc cca att ttg ggc 307Leu Leu Pro Ala Gly Val Leu Ser Glu Thr Ala Thr Pro Ile Leu Gly

55 60 65aac ggc gtt gtg atc aac ctt gag gca ctg ttc gaa gaa atc gac ggc 355Asn Gly Val Val Ile Asn Leu Glu Ala Leu Phe Glu Glu Ile Asp Gly 70 75 80 85ctt gag gct cgc ggt gcg gat gca tcc cgc ctg cgc atc tct gca aac 403Leu Glu Ala Arg Gly Ala Asp Ala Ser Arg Leu Arg Ile Ser Ala Asn

90 95 100gct cac ctg gtt gct cca tac cac cag gtg atg gac cgt gtt cag gaa 451Ala His Leu Val Ala Pro Tyr His Gln Val Met Asp Arg Val Gln Glu

105 110 115cgc ttc ctg ggc aag cgc gca atc ggc acc acc ggc cgt ggc atc ggc 499Arg Phe Leu Gly Lys Arg Ala Ile Gly Thr Thr Gly Arg Gly Ile Gly

120 125 130cca acc tac gcg gac aaa gta tcc cgc gtg gga atc cgt gtt caa gac 547Pro Thr Tyr Ala Asp Lys Val Ser Arg Val Gly Ile Arg Val Gln Asp

135 140 145att ttc gac gaa tcc atc ctt cgt caa aaa gtc gaa tcc gcc ctg gat 595Ile Phe Asp Glu Ser Ile Leu Arg Gln Lys Val Glu Ser Ala Leu Asp150155 160 165tac aaa aac cag gtg ctg gtg aag atg tac aac cgc aag gcc atc gtc 643Tyr Lys Asn Gln Val Leu Val Lys Met Tyr Asn Arg Lys Ala Ile Val

170 175 180gct gag gaa atc gtg cag tac ttc ctc tcc tac gct gat cgt ctg cgc 691Ala Glu Glu Ile Val Gln Tyr Phe Leu Ser Tyr Ala Asp Arg Leu Arg

185 190 195ccc atg gtc atc gat gcc acc ttg gtg ctc aac gag gca ctt gat cag 739Pro Met Val Ile Asp Ala Thr Leu Val Leu Asn Glu Ala Leu Asp Gln

200 205 210ggc aag cac gtt ctt atg gaa ggt ggc cag gca acc atg ctc gac gtg 787Gly Lys His Val Leu Met Glu Gly Gly Gln Ala Thr Met Leu Asp Val

215 220 225gac cac ggc acc tac cca ttc gtc acc tcc tcc aac cca acc gcc ggt 835Asp His Gly Thr Tyr Pro Phe Val Thr Ser Ser Asn Pro Thr Ala Gly230 235 240 245ggc gca agt gtt ggt tca ggt atc ggc cca acc aag atc acc agc tcc 883Gly Ala Ser Val Gly Ser Gly Ile Gly Pro Thr Lys Ile Thr Ser Ser

250 255 260ttg ggt atc atc aag gcc tac acc act cgt gtt ggt gcc ggc cca ttc 931Leu Gly Ile Ile Lys Ala Tyr Thr Thr Arg Val Gly Ala Gly Pro Phe

265 270 275cca act gag ctg ttt gat aag tgg ggc gag tac ctg cag acc gtc ggt 979Pro Thr Glu Leu Phe Asp Lys Trp Gly Glu Tyr Leu Gln Thr Val Gly

280 285 290ggc gag gtc ggc gtg aac acc ggc cgt aag cgt cgc tgt ggc tgg tac 1027Gly Glu Val Gly Val Asn Thr Gly Arg Lys Arg Arg Cys Gly Trp Tyr

295 300 305gac tcc gtg att gct cgt tac gca tcc cgc gtc aac gga ttc acc gac 1075Asp Ser Val Ile Ala Arg Tyr Ala Ser Arg Val Asn Gly Phe Thr Asp310 315 320 325tac ttc ctg acc aag cta gac gtg ctc acc ggc atc ggt gaa atc cca 1123Tyr Phe Leu Thr Lys Leu Asp Val Leu Thr Gly Ile Gly Glu Ile Pro

330 335 340atc tgc gta gct tac gac gtt gat ggt gtt cgc cac gat gaa atg cca 1171Ile Cys Val Ala Tyr Asp Val Asp Gly Val Arg His Asp Glu Met Pro

345 350 355ctg acc cag tca gag ttc cac cac gca acc cca atc ttt gaa acc atg 1219Leu Thr Gln Ser Glu Phe His His Ala Thr Pro Ile Phe Glu Thr Met

360 365 370cct gca tgg gac gaa gac atc acc gac tgc aag acc ttc gag gat ctt 1267Pro Ala Trp Asp Glu Asp Ile Thr Asp Cys Lys Thr Phe Glu Asp Leu

375 380 385cca caa aag gcc cag gac tac gtc cga cgt ctg gaa gaa ctc tct ggt 1315Pro Gln Lys Ala Gln Asp Tyr Val Arg Arg Leu Glu Glu Leu Ser Gly390 395 400 405gct cgc ttc tcc tac atc ggt gtt gga cct ggt cgc gat cag acc atc 1363Ala Arg Phe Ser Tyr Ile Gly Val Gly Pro Gly Arg Asp Gln Thr Ile

410 415 420gtc ctg cat gac gta cta gct gac aac tagtactgat aaacatcagt 1410Val Leu His Asp Val Leu Ala Asp Asn

425430 gag 1413<2l0>960<211>430<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>960Met Ala Ala Ile Val Ile Val Gly Ala Gln Trp Gly Asp Glu Gly Lys 151015 Gly Lys Ala Thr Asp Ile Leu Gly Gly Leu Val Asp Tyr Val Val Lys

20 25 30Pro Asn Gly Gly Asn Asn Ala Gly His Thr Val Val Val Gly Gly Glu

35 40 45Lys Tyr Glu Leu Lys Leu Leu Pro Ala Gly Val Leu Ser Glu Thr Ala

50 55 60Thr Pro Ile Leu Gly Asn Gly Val Val Ile Asn Leu Glu Ala Leu Phe 65 70 75 80Glu Glu Ile Asp Gly Leu Glu Ala Arg Gly Ala Asp Ala Ser Arg Leu

85 90 95Arg Ile Ser Ala Asn Ala His Leu Val Ala Pro Tyr His Gln Val Met

100 105 110Asp Arg Val Gln Glu Arg Phe Leu Gly Lys Arg Ala Ile Gly Thr Thr

115 120 125Gly Arg Gly Ile Gly Pro Thr Tyr Ala Asp Lys Val Ser Arg Val Gly

130 135 140Ile Arg Val Gln Asp Ile Phe Asp Glu Ser Ile Leu Arg Gln Lys Val145 150 155 160Glu Ser Ala Leu Asp Tyr Lys Asn Gln Val Leu Val Lys Met Tyr Asn

165 170 175Arg Lys Ala Ile Val Ala Glu Glu Ile Val Gln Tyr Phe Leu Ser Tyr

180 185 190Ala Asp Arg Leu Arg Pro Met Val Ile Asp Ala Thr Leu Val Leu Asn

195 200 205Glu Ala Leu Asp Gln Gly Lys His Val Leu Met Glu Gly Gly Gln Ala

210 215 220Thr Met Leu Asp Val Asp His Gly Thr Tyr Pro Phe Val Thr Ser Ser225 230 235 240Asn Pro Thr Ala Gly Gly Ala Ser Val Gly Ser Gly Ile Gly Pro Thr

245 250 255Lys Ile Thr Ser Ser Leu Gly Ile Ile Lys Ala Tyr Thr Thr Arg Val

260 265 270Gly Ala Gly Pro Phe Pro Thr Glu Leu Phe Asp Lys Trp Gly Glu Tyr

275 280 285Leu Gln Thr Val Gly Gly Glu Val Gly Val Asn Thr Gly Arg Lys Arg

290 295 300Arg Cys Gly Trp Tyr Asp Ser Val Ile Ala Arg Tyr Ala Ser Arg Val305 310 315 320Asn Gly Phe Thr Asp Tyr Phe Leu Thr Lys Leu Asp Val Leu Thr Gly

325 330 335Ile Gly Glu Ile Pro Ile Cys Val Ala Tyr Asp Val Asp Gly Val Arg

340 345 350His Asp Glu Met Pro Leu Thr Gln Ser Glu Phe His His Ala Thr Pro

355 360 365Ile Phe Glu Thr Met Pro Ala Trp Asp Glu Asp Ile Thr Asp Cys Lys

370 375 380Thr Phe Glu Asp Leu Pro Gln Lys Ala Gln Asp Tyr Val Arg Arg Leu385 390 395 400Glu Glu Leu Ser Gly Ala Arg Phe Ser Tyr Ile Gly Val Gly Pro Gly

405 410 415Arg Asp Gln Thr Ile Val Leu His Asp Val Leu Ala Asp Asn

420425430<210>961<211>1551<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1528)<223>RXA00619<400>961tcaaaggaag acaccattga aggtgtgcgc aaaatcggag aattcatcaa aaaatagcag 60cgactaggtt agtttcggtt cgtggggaat aataatttgc gtg gct gat aaa aag 115

Val Ala Asp Lys Lys

1 5aag atc gca aac gtc ctg tcg aac cgt tac gcc tcc gcg gaa ctt tct 163Lys Ile Ala Asn Val Leu Ser Asn Arg Tyr Ala Ser Ala Glu Leu Ser

10 15 20aac ctg tgg agt gcc gaa gag aag atc atc atg gag cgc cag ctc tgg 211Asn Leu Trp Ser Ala Glu Glu Lys Ile Ile Met Glu Arg Gln Leu Trp

25 30 35atc gcc gtg atg aaa gcc cag aaa gat ttg gga gtt gag atc cct gcc 259Ile Ala Val Met Lys Ala Gln Lys Asp Leu Gly Val Glu Ile Pro Ala

40 45 50gag gca att gaa tcc tat gaa gca gtg atc gac cag gtt gat ttg gca 307Glu Ala Ile Glu Ser Tyr Glu Ala Val Ile Asp Gln Val Asp Leu Ala

55 60 65agc atc gcc gat cgt gag cgc gtc acc cgc cac gat gtg aag gcc cgc 355Ser Ile Ala Asp Arg Glu Arg Val Thr Arg His Asp Val Lys Ala Arg 70 75 80 85atc gaa gaa ttc aat gca ctg gct ggc cat gag cac atc cac aag ggc 403Ile Glu Glu Phe Asn Ala Leu Ala Gly His Glu His Ile His Lys Gly

90 95 100atg acc tcc cgc gac ctc acc gaa aat gtt gaa cag ctg cag atc cac 451Met Thr Ser Arg Asp Leu Thr Glu Asn Val Glu Gln Leu Gln Ile His

105 110 115cgc tcc ctt gag ctg gtc cgc aac aag ggc att gca gtt gtt gca gct 499Arg Ser Leu Glu Leu Val Arg Asn Lys Gly Ile Ala Val Val Ala Ala

120 125 130atc gga tcc cgc gca gcg cag tac caa agc ctg gtc atg gct ggc cgt 547Ile Gly Ser Arg Ala Ala Gln Tyr Gln Ser Leu Val Met Ala Gly Arg

135 140 145tcc cac aac gtg gca gcg cag gca act acc ttg ggc aag cgt ttc gca 595Ser His Asn Val Ala Ala Gln Ala Thr Thr Leu Gly Lys Arg Phe Ala150 155 160 165acc gca gct gat gaa atg ctc gtg gca ctt gag cgc gtc acc gaa ctg 643Thr Ala Ala Asp Glu Met Leu Val Ala Leu Glu Arg Val Thr Glu Leu

170 175 180ctc aac cgc tac cca ctt cgc gga atc aag ggc cca atg gga acc gcc 691Leu Asn Arg Tyr Pro Leu Arg Gly Ile Lys Gly Pro Met Gly Thr Ala

185 190 195caa gac atg ctt gac ctc atg gaa ggc gac gag gct cgt ctc tcc gat 739Gln Asp Met Leu Asp Leu Met Glu Gly Asp Glu Ala Arg Leu Ser Asp

200 205 210ctg gaa acc cgc atc gca gca cac ctc ggc ttt gat cgc gtc ttc gac 787Leu Glu Thr Arg Ile Ala Ala His Leu Gly Phe Asp Arg Val Phe Asp

215 220 225tcc gtc ggc cag gtc tac cca cgt tcc ctt gac ttc gat gca gta tct 835Ser Val Gly Gln Val Tyr Pro Arg Ser Leu Asp Phe Asp Ala Val Ser230 235 240 245gct ctg gtt cag ctt ggc tcc ggc cca tca tcg ctg tcc cac acc att 883Ala Leu Val Gln Leu Gly Ser Gly Pro Ser Ser Leu Ser His Thr Ile

250 255 260cgt ctc atg gcc ggc acc gaa act gtt acc gaa ggt ttt aag gaa ggc 931Arg Leu Met Ala Gly Thr Glu Thr Val Thr Glu Gly Phe Lys Glu Gly

265 270 275cag gtc ggt tcc tct gca atg cct cac aag atg aac gct cgc tcc tgt 979Gln Val Gly Ser Ser Ala Met Pro His Lys Met Asn Ala Arg Ser Cys

280 285 290gag cgc gtg ggc ggc ctg cag gtt att ctt cgc gga tac ctc acc atg 1027Glu Arg Val Gly Gly Leu Gln Val Ile Leu Arg Gly Tyr Leu Thr Met

295 300 305gtt gct gat ctt tcc ggc cag cag tgg aac gaa ggc gat gtc ttc tgc 1075Val Ala Asp Leu Ser Gly Gln Gln Trp Asn Glu Gly Asp Val Phe Cys310 315 320 325tcc gtg atc cgc cgc gtt gca ctg cca gac gca ttc ttc gcg att gac 1123Ser Val Ile Arg Arg Val Ala Leu Pro Asp Ala Phe Phe Ala Ile Asp

330 335 340gga atg ttt gaa act ttc ctg aca gtc ctg gat gaa ttc ggt gca ttc 1171Gly Met Phe Glu Thr Phe Leu Thr Val Leu Asp Glu Phe Gly Ala Phe

345 350 355cct gcc atg atc gag cgc gaa ctt gag cgt tac ctg cca ttc ctg gca 1219Pro Ala Met Ile Glu Arg Glu Leu Glu Arg Tyr Leu Pro Phe Leu Ala

360 365 370act acc cgt atc ctc atg gcc gct gtc cgc gca ggc gtt ggc cgc gaa 1267Thr Thr Arg Ile Leu Met Ala Ala Val Arg Ala Gly Val Gly Arg Glu

375 380 385acc gca cac gaa gta atc aag gaa aac gct gtc gcg gtt gcc ctc aac 1315Thr Ala His Glu Val Ile Lys Glu Asn Ala Val Ala Val Ala Leu Asn390 395 400 405atg cgc gaa aat ggc ggt gac cag gac ctt atc cag cgc ctc gct gct 1363Met Arg Glu Asn Gly Gly Asp Gln Asp Leu Ile Gln Arg Leu Ala Ala

410 415 420gat gag cgc ctc cca atg agc gaa gct gac ctt gag gca gcg ctg gct 1411Asp Glu Arg Leu Pro Met Ser Glu Ala Asp Leu Glu Ala Ala Leu Ala

425 430 435gac cgc cac gcc ttc atc ggt gcc gct gag tcc cag gtc tcc cgt gtg 1459Asp Arg His Ala Phe Ile Gly Ala Ala Glu Ser Gln Val Ser Arg Val

440 445 450ctc gac cgc att cag gtg ctt gtc gac gcc cac ccc ggc gcc gca gac 1507Leu Asp Arg Ile Gln Val Leu Val Asp Ala His Pro Gly Ala Ala Asp

455460465 tac cga cca ggt gag att ctt taaaggtttt taacggcgtt cac 1551Tyr Arg Pro Gly Glu Ile Leu 470475<210>962<211>476<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>962Val Ala Asp Lys Lys Lys Ile Ala Asn Val Leu Ser Asn Arg Tyr Ala 151015 Ser Ala Glu Leu Ser Asn Leu Trp Ser Ala Glu Glu Lys Ile Ile Met

20 25 30Glu Arg Gln Leu Trp Ile Ala Val Met Lys Ala Gln Lys Asp Leu Gly

35 40 45Val Glu Ile Pro Ala Glu Ala Ile Glu Ser Tyr Glu Ala Val Ile Asp

50 55 60Gln Val Asp Leu Ala Ser Ile Ala Asp Arg Glu Arg Val Thr Arg His 65 70 75 80Asp Val Lys Ala Arg Ile Glu Glu Phe Asn Ala Leu Ala Gly His Glu

85 90 95His Ile His Lys Gly Met Thr Ser Arg Asp Leu Thr Glu Asn Val Glu

100 105 110Gln Leu Gln Ile His Arg Ser Leu Glu Leu Val Arg Asn Lys Gly Ile

115 120 125Ala Val Val Ala Ala Ile Gly Ser Arg Ala Ala Gln Tyr Gln Ser Leu

130 135 140Val Met Ala Gly Arg Ser His Asn Val Ala Ala Gln Ala Thr Thr Leu145 150 155 160Gly Lys Arg Phe Ala Thr Ala Ala Asp Glu Met Leu Val Ala Leu Glu

165 170 175Arg Val Thr Glu Leu Leu Asn Arg Tyr Pro Leu Arg Gly Ile Lys Gly

180185 190Pro Met Gly Thr Ala Gln Asp Met Leu Asp Leu Met Glu Gly Asp Glu

195 200 205Ala Arg Leu Ser Asp Leu Glu Thr Arg Ile Ala Ala His Leu Gly Phe

210 215 220Asp Arg Val Phe Asp Ser Val Gly Gln Val Tyr Pro Arg Ser Leu Asp225 230 235 240Phe Asp Ala Val Ser Ala Leu Val Gln Leu Gly Ser Gly Pro Ser Ser

245 250 255Leu Ser His Thr Ile Arg Leu Met Ala Gly Thr Glu Thr Val Thr Glu

260 265 270Gly Phe Lys Glu Gly Gln Val Gly Ser Ser Ala Met Pro His Lys Met

275 280 285Asn Ala Arg Ser Cys Glu Arg Val Gly Gly Leu Gln Val Ile Leu Arg

290 295 300Gly Tyr Leu Thr Met Val Ala Asp Leu Ser Gly Gln Gln Trp Asn Glu305 310 315 320Gly Asp Val Phe Cys Ser Val Ile Arg Arg Val Ala Leu Pro Asp Ala

325 330 335Phe Phe Ala Ile Asp Gly Met Phe Glu Thr Phe Leu Thr Val Leu Asp

340 345 350Glu Phe Gly Ala Phe Pro Ala Met Ile Glu Arg Glu Leu Glu Arg Tyr

355 360 365Leu Pro Phe Leu Ala Thr Thr Arg Ile Leu Met Ala Ala Val Arg Ala

370 375 380Gly Val Gly Arg Glu Thr Ala His Glu Val Ile Lys Glu Asn Ala Val385 390 395 400Ala Val Ala Leu Asn Met Arg Glu Asn Gly Gly Asp Gln Asp Leu Ile

405410 415Gln Arg Leu Ala Ala Asp Glu Arg Leu Pro Met Ser Glu Ala Asp Leu

420 425 430Glu Ala Ala Leu Ala Asp Arg His Ala Phe Ile Gly Ala Ala Glu Ser

435 440 445Gln Val Ser Arg Val Leu Asp Arg Ile Gln Val Leu Val Asp Ala His

450455460 Pro Gly Ala Ala Asp Tyr Arg Pro Gly Glu Ile Leu 465470475<210>963<211>666<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<643>RXA00688<400>963gcggaaccgc aatcttgatt cttgtatctg ttgcactgac cacagtgaag cagattgaga 60gccagctcct gcaaagcaac tacgaaggac ttctaaaata atg cga ctc gta ctc 115

Met Arg Leu Val Leu

1 5ctc gga cct ccc ggt gct ggt aag ggc acc cag gct gca att ctc tct 163Leu Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Ala Ile Leu Ser

10 15 20gag aag ctt ggc att cct cac att tct act ggc gat ctt ttc cgc gcc 211Glu Lys Leu Gly Ile Pro His Ile Ser Thr Gly Asp Leu Phe Arg Ala

25 30 35aac att ggc gaa ggt acc cct ctg ggt atc gag gcc aag cag tac atc 259Asn Ile Gly Glu Gly Thr Pro Leu Gly Ile Glu Ala Lys Gln Tyr Ile

40 45 50gac gct ggc aag ctg gtt cca acc gac gtg act gca cgt atg gtt gct 307Asp Ala Gly Lys Leu Val Pro Thr Asp Val Thr Ala Arg Met Val Ala

55 60 65tcc cgc ctt gct gag tcc gat gct gca gaa ggc ttc ctt ttg gat ggt 355Ser Arg Leu Ala Glu Ser Asp Ala Ala Glu GlyPhe Leu Leu Asp Gly 70 75 80 85ttc cca cgc acc gtt gag cag gct gac atc ttg gct aac ctg ctt tcc 403Phe Pro Arg Thr Val Glu Gln Ala Asp Ile Leu Ala Asn Leu Leu Ser

90 95 100gaa gct ggc cag acc ctc gat ggt gtt gtt aac tac cag gtt tct gaa 451Glu Ala Gly Gln Thr Leu Asp Gly Val Val Asn Tyr Gln Val Ser Glu

105 110 115gac gtc gtc gtg gag cgc atg ctg tcc cgt ggt cgc gct gat gac aac 499Asp Val Val Val Glu Arg Met Leu Ser Arg Gly Arg Ala Asp Asp Asn

120 125 130gaa gag acc atc cgc acc cgt ctc ggt gtc tac cgc gac gag act gct 547Glu Glu Thr Ile Arg Thr Arg Leu Gly Val Tyr Arg Asp Glu Thr Ala

135 140 145cct ctg atc gat cac tac ggt gac aag atc atc aac att gag gct gaa 595Pro Leu Ile Asp His Tyr Gly Asp Lys Ile Ile Asn Ile Glu Ala Glu150 155 160 165ggc gaa gtc gaa gag atc aac gct cgt acc ctc aag gca ctg ggc aaa 643Gly Glu Val Glu Glu Ile Asn Ala Arg Thr Leu Lys Ala Leu Gly Lys

170175180 taagatttct tctctagtgc tgc 666<210>964<211>181<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>964Met Arg Leu Val Leu Leu Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln 151015 Ala Ala Ile Leu Ser Glu Lys Leu Gly Ile Pro His Ile Ser Thr Gly

20 25 30Asp Leu Phe Arg Ala Asn Ile Gly Glu Gly Thr Pro Leu Gly Ile Glu

35 40 45Ala Lys Gln Tyr Ile Asp Ala Gly Lys Leu Val Pro Thr Asp Val Thr

50 55 60Ala Arg MetVal Ala Ser Arg Leu Ala Glu Ser Asp Ala Ala Glu Gly 65 70 75 80Phe Leu Leu Asp Gly Phe Pro Arg Thr Val Glu Gln Ala Asp Ile Leu

85 90 95Ala Asn Leu Leu Ser Glu Ala Gly Gln Thr Leu Asp Gly Val Val Asn

100 105 110Tyr Gln Val Ser Glu Asp Val Val Val Glu Arg Met Leu Ser Arg Gly

115 120 125Arg Ala Asp Asp Asn Glu Glu Thr Ile Arg Thr Arg Leu Gly Val Tyr

130 135 140Arg Asp Glu Thr Ala Pro Leu Ile Asp His Tyr Gly Asp Lys Ile Ile145 150 155 160Asn Ile Glu Ala Glu Gly Glu Val Glu Glu Ile Asn Ala Arg Thr Leu

165 170 175Lys Ala Leu Gly Lys

180<210>965<211>531<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (508)<223>RXA00266<400>965agtaggggat cgtccagcga agcggtcgca gaggctgtga ggaagctcta agtcgactta 60agtgcgcgaa gcagaccacc attaggtaga atcacccaac atg act gaa cgt act 115

Met Thr Glu Arg Thr

1 5ctc atc ctt atc aag cca gac ggt gtt acc aac gga cac gtc ggc gaa 163Leu Ile Leu Ile Lys Pro Asp Gly Val Thr Asn Gly His Val Gly Glu

10 15 20atc atc gca cgt att gag cgc aag ggc ctg aag ctc gct gct ctg gat 211Ile Ile Ala Arg Ile Glu Arg Lys Gly Leu Lys Leu Ala Ala Leu Asp

25 3035ctg cgt gtt gca gac cgc gag acc gct gaa aag cac tac gaa gag cac 259Leu Arg Val Ala Asp Arg Glu Thr Ala Glu Lys His Tyr Glu Glu His

40 45 50gct gac aag cca ttc ttc ggt gag ctc gtt gaa ttc atc acc tct gca 307Ala Asp Lys Pro Phe Phe Gly Glu Leu Val Glu Phe Ile Thr Ser Ala

55 60 65cct ctg atc gca ggc atc gtc gaa ggc gag cgt gca atc gat gca tgg 355Pro Leu Ile Ala Gly Ile Val Glu Gly Glu Arg Ala Ile Asp Ala Trp 70 75 80 85cgt cag ctt gct ggt ggc acc gac cca gtt gct aag gca acc cca ggc 403Arg Gln Leu Ala Gly Gly Thr Asp Pro Val Ala Lys Ala Thr Pro Gly

90 95 100acc atc cgc ggc gat ttc gca ctg act gtt gga gag aac gtt gtt cac 451Thr Ile Arg Gly Asp Phe Ala Leu Thr Val Gly Glu Asn Val Val His

105 110 115ggt tct gat tcc cca gag tcc gct gag cgc gag atc tcc atc tgg ttc 499Gly Ser Asp Ser Pro Glu Ser Ala Glu Arg Glu Ile Ser Ile Trp Phe

120 125 130cct aac ctg taatttttac ggttagaaaa aaa 531Pro Asn Leu

135<210>966<211>136<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>966Met Thr Glu Arg Thr Leu Ile Leu Ile Lys Pro Asp Gly Val Thr Asn 151015 Gly His Val Gly Glu Ile Ile Ala Arg Ile Glu Arg Lys Gly Leu Lys

20 25 30Leu Ala Ala Leu Asp Leu Arg Val Ala Asp Arg Glu Thr Ala Glu Lys

35 40 45His Tyr Glu Glu His Ala Asp Lys Pro Phe Phe Gly Glu Leu Val Glu

5055 60Phe Ile Thr Ser Ala Pro Leu Ile Ala Gly Ile Val Glu Gly Glu Arg 65 70 75 80Ala Ile Asp Ala Trp Arg Gln Leu Ala Gly Gly Thr Asp Pro Val Ala

85 90 95Lys Ala Thr Pro Gly Thr Ile Arg Gly Asp Phe Ala Leu Thr Val Gly

100 105 110Glu Asn Val Val His Gly Ser Asp Ser Pro Glu Ser Ala Glu Arg Glu

115 120 125Ile Ser Ile Trp Phe Pro Asn Leu

130135<210>967<211>1245<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<1222)<223>RXA00489<400>967cagcccgatt tcttcattga aatcgggctg tttctggttg tgtcgcgtat ctcgggtaaa 60gtcttcgtcg tatacgacca tttaagggag gcccgtcaca atg cgt gac cac gtt 115

Met Arg Asp His Val

1 5gaa atc ggt atc ggc cgt gag gca cga cgc acc tac agc ttg gac gat 163Glu Ile Gly Ile Gly Arg Glu Ala Arg Arg Thr Tyr Ser Leu Asp Asp

10 15 20att tct gtc gtt tct agc cgc cgc acc cgt tca tcc aaa gat gtc gac 211Ile Ser Val Val Ser Ser Arg Arg Thr Arg Ser Ser Lys Asp Val Asp

25 30 35acc act tgg cat att gac gcc tac aag ttt gat ctg ccg ttc atg aat 259Thr Thr Trp His Ile Asp Ala Tyr Lys Phe Asp Leu Pro Phe Met Asn

40 45 50cac cca agt gat gca ttg gca agc cct gag ttt gtc att gaa atg ggc 307His Pro Ser Asp Ala Leu Ala Ser ProGlu Phe Val Ile Glu Met Gly

55 60 65aag cag ggt ggc ctt ggc gtg atc aac gct gag ggt ctg tgg ggt cgc 355Lys Gln Gly Gly Leu Gly Val Ile Asn Ala Glu Gly Leu Trp Gly Arg 70 75 80 85cat gct gat ctc gat gag gcg atc gca aag gtg att gct gcg tat gag 403His Ala Asp Leu Asp Glu Ala Ile Ala Lys Val Ile Ala Ala Tyr Glu

90 95 100gaa ggc gac cag gct gca gcc act cgc act ctt cag gag ctg cac gca 451Glu Gly Asp Gln Ala Ala Ala Thr Arg Thr Leu Gln Glu Leu His Ala

105 110 115gcg cca ctg gat act gag ctg ctg agt gag cgc att gcg cag gtt cgt 499Ala Pro Leu Asp Thr Glu Leu Leu Ser Glu Arg Ile Ala Gln Val Arg

120 125 130gat tcc ggt gag atc gtt gct gtg cgc gtg tct cca caa aat gtt cgt 547Asp Ser Gly Glu Ile Val Ala Val Arg Val Ser Pro Gln Asn Val Arg

135 140 145gag atc gca cca atc gtc atc aag gca ggt gct gat ctg ctg gtt atc 595Glu Ile Ala Pro Ile Val Ile Lys Ala Gly Ala Asp Leu Leu Val Ile150 155 160 165cag ggc acc ctg atc tct gca gag cac gtc aac acc ggt gga gag gcc 643Gln Gly Thr Leu Ile Ser Ala Glu His Val Asn Thr Gly Gly Glu Ala

170 175 180ctg aac cta aag gaa ttc atc ggt tct ttg gat gtt cct gtc atc gct 691Leu Asn Leu Lys Glu Phe Ile Gly Ser Leu Asp Val Pro Val Ile Ala

185 190 195ggt ggc gtg aac gat tac acc acc gcg ttg cac atg atg cgt acc ggt 739Gly Gly Val Asn Asp Tyr Thr Thr Ala Leu His Met Met Arg Thr Gly

200 205 210gct gtg ggcatc atc gtc ggt ggc ggc gag aac acc aac agc cta gca 787Ala Val Gly Ile Ile Val Gly Gly Gly Glu Asn Thr Asn Ser Leu Ala

215 220 225ttg ggc atg gag gta tcc atg gcc act gcg att gct gat gtc gct gcg 835Leu Gly Met Glu Val Ser Met Ala Thr Ala Ile Ala Asp Val Ala Ala230 235 240 245gca cgt cgt gat tac ctg gat gag acc ggt gga cgt tac gtg cac atc 883Ala Arg Arg Asp Tyr Leu Asp Glu Thr Gly Gly Arg Tyr Val His Ile

250 255 260att gca gat gga agc att gaa aac tcc ggt gat gta gtc aag gct att 931Ile Ala Asp Gly Ser Ile Glu Asn Ser Gly Asp Val Val Lys Ala Ile

265 270 275gcc tgt ggc gca gat gct gtg gtg ctg ggt tca ccg ttg gct cgc gct 979Ala Cys Gly Ala Asp Ala Val Val Leu Gly Ser Pro Leu Ala Arg Ala

280 285 290gaa gaa gct gct gga aag ggc tac ttc tgg cca gca gtg gca gcg cac 1027Glu Glu Ala Ala Gly Lys Gly Tyr Phe Trp Pro Ala Val Ala Ala His

295 300 305cct cgt ttc cca cgc ggt gtg gtt act gag tcc gtg gac ttg gat gag 1075Pro Arg Phe Pro Arg Gly Val Val Thr Glu Ser Val Asp Leu Asp Glu310 315 320 325gca gca cca agc ttg gag cag att ctg cat ggt ccg tct acg atg ccg 1123Ala Ala Pro Ser Leu Glu Gln Ile Leu His Gly Pro Ser Thr Met Pro

330 335 340tgg ggt gtg gaa aac ttc gaa ggt gga tta aag cgt gcg ctg gct aag 1171Trp Gly Val Glu Asn Phe Glu Gly Gly Leu Lys Arg Ala Leu Ala Lys

345 350 355tgt ggc tac acc gat ttg aag agc ttc caa aag gta agc ctg cac gtt 1219Cys Gly Tyr Thr Asp Leu Lys Ser Phe Gln Lys Val Ser Leu His Val

360365370 aac taggtgtgtg tactcgcctc ttc 1245Asn<5>Asn<210>968<211>374<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>968Met Arg Asp His Val Glu Ile Gly Ile Gly Arg Glu Ala Arg Arg Thr 151015 Tyr Ser Leu Asp Asp Ile Ser Val Val Ser Ser Arg Arg Thr Arg Ser

20 25 30Ser Lys Asp Val Asp Thr Thr Trp His Ile Asp Ala Tyr Lys Phe Asp

35 40 45Leu Pro Phe Met Asn His Pro Ser Asp Ala Leu Ala Ser Pro Glu Phe

50 55 60Val Ile Glu Met Gly Lys Gln Gly Gly Leu Gly Val Ile Asn Ala Glu 65 70 75 80Gly Leu Trp Gly Arg His Ala Asp Leu Asp Glu Ala Ile Ala Lys Val

85 90 95Ile Ala Ala Tyr Glu Glu Gly Asp Gln Ala Ala Ala Thr Arg Thr Leu

100 105 110Gln Glu Leu His Ala Ala Pro Leu Asp Thr Glu Leu Leu Ser Glu Arg

115 120 125Ile Ala Gln Val Arg Asp Ser Gly Glu Ile Val Ala Val Arg Val Ser

130 135 140Pro Gln Asn Val Arg Glu Ile Ala Pro Ile Val Ile Lys Ala Gly Ala145 150 155 160Asp Leu Leu Val Ile Gln Gly Thr Leu Ile Ser Ala Glu His Val Asn

165 170 175Thr Gly Gly Glu Ala Leu Asn Leu Lys Glu Phe Ile Gly Ser Leu Asp

180 185 190Val Pro Val Ile Ala Gly Gly Val Asn Asp Tyr Thr Thr Ala Leu His

195 200 205Met Met Arg Thr Gly Ala Val Gly Ile Ile Val Gly Gly Gly Glu Asn

210 215 220Thr Asn Ser Leu Ala Leu Gly Met Glu Val Ser Met Ala Thr Ala Ile225 230 235 240Ala Asp Val Ala Ala Ala Arg Arg Asp Tyr Leu Asp Glu Thr Gly Gly

245 250 255Arg Tyr Val His Ile Ile Ala Asp Gly Ser Ile Glu Asn Ser Gly Asp

260 265 270Val Val Lys Ala Ile Ala Cys Gly Ala Asp Ala Val Val Leu Gly Ser

275 280 285Pro Leu Ala Arg Ala Glu Glu Ala Ala Gly Lys Gly Tyr Phe Trp Pro

290 295 300Ala Val Ala Ala His Pro Arg Phe Pro Arg Gly Val Val Thr Glu Ser305 310 315 320Val Asp Leu Asp Glu Ala Ala Pro Ser Leu Glu Gln Ile Leu His Gly

325 330 335Pro Ser Thr Met Pro Trp Gly Val Glu Asn Phe Glu Gly Gly Leu Lys

340 345 350Arg Ala Leu Ala Lys Cys Gly Tyr Thr Asp Leu Lys Ser Phe Gln Lys

355 360 365Val Ser Leu His Val Asn

370<210>969<211>1545<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1531)<223>RXN02281<400>969aagatcaaca acgccgccga ggtcaacttg gaaattatca cgtgaggatt cttgcatacg 60cctataaaag cacagttttg aatccacagg gcatcagggc gtg cag aaa gat agt 115

Val Gln Lys Asp Ser

1 5gtg gtg cgc atg gaa gca aca acg atc gat gac gca atc gcg aag ctc 163Val Val Arg Met Glu Ala Thr Thr Ile Asp Asp Ala Ile Ala Lys Leu

10 15 20att gac atc tac gac acc tcg acc aaa ctg gcc aaa gaa acc ctc aac 211Ile Asp Ile Tyr Asp Thr Ser Thr Lys Leu Ala Lys Glu Thr Leu Asn

25 30 35aat gag gac tac gcc gca tac gcc gat gtt gtt tac ccc aaa ctc acc 259Asn Glu Asp Tyr Ala Ala Tyr Ala Asp Val Val Tyr Pro Lys Leu Thr

40 45 50gtt gac gtg ctg gaa tgg aaa ccc atc gac cgc acc gaa ccc ttc ggc 307Val Asp Val Leu Glu Trp Lys Pro Ile Asp Arg Thr Glu Pro Phe Gly

55 60 65tat gtg gat cga gcc ggg cga tac tcc gcc acc ttg tcc aaa cca cgc 355Tyr Val Asp Arg Ala Gly Arg Tyr Ser Ala Thr Leu Ser Lys Pro Arg 70 75 80 85gtg att gag cgt tac ctc cgc gaa caa ctc gag cgt ctc acc agt aat 403Val Ile Glu Arg Tyr Leu Arg Glu Gln Leu Glu Arg Leu Thr Ser Asn

90 95 100tat ccc tgc aag att tac gta tct gag tca gat atc cgc atc cca ccg 451Tyr Pro Cys Lys Ile Tyr Val Ser Glu Ser Asp Ile Arg Ile Pro Pro

105 110 115gag tac att cgc ggc gca cct tcc gct acc gaa gct cgc cgt gct ggt 499Glu Tyr Ile Arg Gly Ala Pro Ser Ala Thr Glu Ala Arg Arg Ala Gly

120 125 130gat gtt gca gat atc atc cca cgc ccc acc ctg gat gaa gtc cac gac 547Asp Val Ala Asp Ile Ile Pro Arg Pro Thr Leu Asp Glu Val His Asp

135 140145gca att atc gac ggc gac tgg cac gcc ttc aac ggc ccc gaa ctc ccg 595Ala Ile Ile Asp Gly Asp Trp His Ala Phe Asn Gly Pro Glu Leu Pro150 155 160 165ctt ttc cac ttc ggg ccg caa cgc ttc gac atc gcc tgc gcc cgc atc 643Leu Phe His Phe Gly Pro Gln Arg Phe Asp Ile Ala Cys Ala Arg Ile

170 175 180gag cac tac acc ggc atc aac gtg gaa cac gtg cag aag tac att ctg 691Glu His Tyr Thr Gly Ile Asn Val Glu His Val Gln Lys Tyr Ile Leu

185 190 195ttc acc aac tac gcc atg cac acc acc gag ttc gtg cat ttt gcc atg 739Phe Thr Asn Tyr Ala Met His Thr Thr Glu Phe Val His Phe Ala Met

200 205 210tcc gaa ctc acc tcg gaa gac tcc cgc tac gtg ggt cta tcc ttg cca 787Ser Glu Leu Thr Ser Glu Asp Ser Arg Tyr Val Gly Leu Ser Leu Pro

215 220 225aac ggg cag gta att gac cga gag acc gcc acc agc ctc ggt acg gaa 835Asn Gly Gln Val Ile Asp Arg Glu Thr Ala Thr Ser Leu Gly Thr Glu230 235 240 245acc ctt gat ctg act agc cgt ttc caa atg cct cgt tac gat ctc atc 883Thr Leu Asp Leu Thr Ser Arg Phe Gln Met Pro Arg Tyr Asp Leu Ile

250 255 260acc gaa gcc ggt gac ggt att acc att atc aac atc ggt gtg ggc cca 931Thr Glu Ala Gly Asp Gly Ile Thr Ile Ile Asn Ile Gly Val Gly Pro

265 270 275tcc aat gca aaa act atc acc gac tgc ctt gct gtg ctc cgc cca gaa 979Ser Asn Ala Lys Thr Ile Thr Asp Cys Leu Ala Val Leu Arg Pro Glu

280 285 290gcc tgg gtg atg atc ggc cac tgt gct ggc atg gac gcc cgc atg cgc 1027Ala TrpVal Met Ile Gly His Cys Ala Gly Met Asp Ala Arg Met Arg

295 300 305atc ggc gac ctc atc ctt ggc aac gcc tac cag cgc gaa gac cac att 1075Ile Gly Asp Leu Ile Leu Gly Asn Ala Tyr Gln Arg Glu Asp His Ile310 315 320 325ctg aat acc cgc atc cca ctt ggt aat ccg atc ccg gca ata cca gaa 1123Leu Asn Thr Arg Ile Pro Leu Gly Asn Pro Ile Pro Ala Ile Pro Glu

330 335 340atc caa aaa gct cta gaa gcc agc gtc gac gaa atc tac gga tcc gac 1171Ile Gln Lys Ala Leu Glu Ala Ser Val Asp Glu Ile Tyr Gly Ser Asp

345 350 355aac agc ctc atg cgc acc ggt acg gtc tta tcc acc gac gac cga aac 1219Asn Ser Leu Met Arg Thr Gly Thr Val Leu Ser Thr Asp Asp Arg Asn

360 365 370tgg gaa tgg cac acc cca gaa aac ctc tgg aac tgg ctc aaa gga tcc 1267Trp Glu Trp His Thr Pro Glu Asn Leu Trp Asn Trp Leu Lys Gly Ser

375 380 385acc gcc gca gct gtt gac atg gaa tct tcc acc ttg gcc acc aac gga 1315Thr Ala Ala Ala Val Asp Met Glu Ser Ser Thr Leu Ala Thr Asn Gly390 395 400 405tat cga ttc cgc att cca tac ggc acc ctg ctg agc gtc tct gac ctg 1363Tyr Arg Phe Arg Ile Pro Tyr Gly Thr Leu Leu Ser Val Ser Asp Leu

410 415 420cca cta cac gca gtg ccg aaa ctt tcc gcg caa gcg cag gcg ttt tac 1411Pro Leu His Ala Val Pro Lys Leu Ser Ala Gln Ala Gln Ala Phe Tyr

425 430 435ttc aac tcc aag gaa gcc cac gtc atg tgt gct gtt cgt gca atg gaa 1459Phe Asn Ser Lys Glu Ala His Val Met Cys Ala Val Arg Ala Met Glu

440 445 450tac ctg gca gta gat cct gaa cgg ttg cgt acc cgt aaa ctg cgc agg 1507Tyr Leu Ala Val Asp Pro Glu Arg Leu Arg Thr Arg Lys Leu Arg Arg

455460465 acc ttg ggt gag gtg ccg ttt cgc taaagtctcg gaga 1545Thr Leu Gly Glu Val Pro Phe Arg 470475<210>970<211>477<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>970Val Gln Lys Asp Ser Val Val Arg Met Glu Ala Thr Thr Ile Asp Asp 151015 Ala Ile Ala Lys Leu Ile Asp Ile Tyr Asp Thr Ser Thr Lys Leu Ala

20 25 30Lys Glu Thr Leu Asn Asn Glu Asp Tyr Ala Ala Tyr Ala Asp Val Val

35 40 45Tyr Pro Lys Leu Thr Val Asp Val Leu Glu Trp Lys Pro Ile Asp Arg

50 55 60Thr Glu Pro Phe Gly Tyr Val Asp Arg Ala Gly Arg Tyr Ser Ala Thr 65 70 75 80Leu Ser Lys Pro Arg Val Ile Glu Arg Tyr Leu Arg Glu Gln Leu Glu

85 90 95Arg Leu Thr Ser Asn Tyr Pro Cys Lys Ile Tyr Val Ser Glu Ser Asp

100 105 110Ile Arg Ile Pro Pro Glu Tyr Ile Arg Gly Ala Pro Ser Ala Thr Glu

115 120 125Ala Arg Arg Ala Gly Asp Val Ala Asp Ile Ile Pro Arg Pro Thr Leu

130 135 140Asp Glu Val His Asp Ala Ile Ile Asp Gly Asp Trp His Ala Phe Asn145 150 155 160Gly Pro Glu Leu Pro Leu Phe His Phe Gly Pro Gln Arg Phe Asp Ile

165 170 175Ala Cys Ala Arg Ile Glu His Tyr Thr GlyIle Asn Val Glu His Val

180 185 190Gln Lys Tyr Ile Leu Phe Thr Asn Tyr Ala Met His Thr Thr Glu Phe

195 200 205Val His Phe Ala Met Ser Glu Leu Thr Ser Glu Asp Ser Arg Tyr Val

210 215 220Gly Leu Ser Leu Pro Asn Gly Gln Val Ile Asp Arg Glu Thr Ala Thr225 230 235 240Ser Leu Gly Thr Glu Thr Leu Asp Leu Thr Ser Arg Phe Gln Met Pro

245 250 255Arg Tyr Asp Leu Ile Thr Glu Ala Gly Asp Gly Ile Thr Ile Ile Asn

260 265 270Ile Gly Val Gly Pro Ser Asn Ala Lys Thr Ile Thr Asp Cys Leu Ala

275 280 285Val Leu Arg Pro Glu Ala Trp Val Met Ile Gly His Cys Ala Gly Met

290 295 300Asp Ala Arg Met Arg Ile Gly Asp Leu Ile Leu Gly Asn Ala Tyr Gln305 310 315 320Arg Glu Asp His Ile Leu Asn Thr Arg Ile Pro Leu Gly Asn Pro Ile

325 330 335Pro Ala Ile Pro Glu Ile Gln Lys Ala Leu Glu Ala Ser Val Asp Glu

340 345 350Ile Tyr Gly Ser Asp Asn Ser Leu Met Arg Thr Gly Thr Val Leu Ser

355 360 365Thr Asp Asp Arg Asn Trp Glu Trp His Thr Pro Glu Asn Leu Trp Asn

370 375 380Trp Leu Lys Gly Ser Thr Ala Ala Ala Val Asp Met Glu Ser Ser Thr385 390 395 400Leu Ala Thr Asn Gly Tyr Arg Phe Arg IlePro Tyr Gly Thr Leu Leu

405 410 415Ser Val Ser Asp Leu Pro Leu His Ala Val Pro Lys Leu Ser Ala Gln

420 425 430Ala Gln Ala Phe Tyr Phe Asn Ser Lys Glu Ala His Val Met Cys Ala

435 440 445Val Arg Ala Met Glu Tyr Leu Ala Val Asp Pro Glu Arg Leu Arg Thr

450455460 Arg Lys Leu Arg Arg Thr Leu Gly Glu Val Pro Phe Arg 465470475<210>971<211>1191<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1168)<223>FRXA02281<400>971aagatcaaca acgccgccga ggtcaacttg gaaattatca cgtgaggatt cttgcatacg 60cctataaaag cacagttttg aatccacagg gcatcagggc gtg cag aaa gat agt 115

Val Gln Lys Asp Ser

1 5gtg gtg cgc atg gaa gca aca acg atc gat gac gca atc gcg aag ctc 163Val Val Arg Met Glu Ala Thr Thr Ile Asp Asp Ala Ile Ala Lys Leu

10 15 20att gac atc tac gac acc tcg acc aaa ctg gcc aaa gaa acc ctc aac 211Ile Asp Ile Tyr Asp Thr Ser Thr Lys Leu Ala Lys Glu Thr Leu Asn

25 30 35aat gag gac tac gcc gca tac gcc gat gtt gtt tac ccc aaa ctc acc 259Asn Glu Asp Tyr Ala Ala Tyr Ala Asp Val Val Tyr Pro Lys Leu Thr

40 45 50gtt gac gtg ctg gaa tgg aaa ccc atc gac cgc acc gaa ccc ttc ggc 307Val Asp Val Leu Glu Trp Lys Pro Ile Asp Arg Thr Glu Pro Phe Gly

55 60 65tat gtg gat cga gcc gggcga tac tcc gcc acc ttg tcc aaa cca cgc 355Tyr Val Asp Arg Ala Gly Arg Tyr Ser Ala Thr Leu Ser Lys Pro Arg 70 75 80 85gtg att gag cgt tac ctc cgc gaa caa ctc gag cgt ctc acc agt aat 403Val Ile Glu Arg Tyr Leu Arg Glu Gln Leu Glu Arg Leu Thr Ser Asn

90 95 100tat ccc tgc aag att tac gta tct gag tca gat atc cgc atc cca ccg 451Tyr Pro Cys Lys Ile Tyr Val Ser Glu Ser Asp Ile Arg Ile Pro Pro

105 110 115gag tac att cgc ggc gca cct tcc gct acc gaa gct cgc cgt gct ggt 499Glu Tyr Ile Arg Gly Ala Pro Ser Ala Thr Glu Ala Arg Arg Ala Gly

120 125 130gat gtt gca gat atc atc cca cgc ccc acc ctg gat gaa gtc cac gac 547Asp Val Ala Asp Ile Ile Pro Arg Pro Thr Leu Asp Glu Val His Asp

135 140 145gca att atc gac ggc gac tgg cac gcc ttc aac ggc ccc gaa ctc ccg 595Ala Ile Ile Asp Gly Asp Trp His Ala Phe Asn Gly Pro Glu Leu Pro150 155 160 165ctt ttc cac ttc ggg ccg caa cgc ttc gac atc gcc tgc gcc cgc atc 643Leu Phe His Phe Gly Pro Gln Arg Phe Asp Ile Ala Cys Ala Arg Ile

170 175 180gag cac tac acc ggc atc aac gtg gaa cac gtg cag aag tac att ctg 691Glu His Tyr Thr Gly Ile Asn Val Glu His Val Gln Lys Tyr Ile Leu

185 190 195ttc acc aac tac gcc atg cac acc acc gag ttc gtg cat ttt gcc atg 739Phe Thr Asn Tyr Ala Met His Thr Thr Glu Phe Val His Phe Ala Met

200 205 210tcc gaa ctc acc tcg gaa gac tcc cgc tac gtg ggt cta tcc ttg cca 787Ser Glu Leu Thr Ser Glu Asp Ser Arg Tyr Val GlyLeu Ser Leu Pro

215 220 225aac ggg cag gta att gac cga gag acc gcc acc agc ctc ggt acg gaa 835Asn Gly Gln Val Ile Asp Arg Glu Thr Ala Thr Ser Leu Gly Thr Glu230 235 240 245acc ctt gat ctg act agc cgt ttc caa atg cct cgt tac gat ctc atc 883Thr Leu Asp Leu Thr Ser Arg Phe Gln Met Pro Arg Tyr Asp Leu Ile

250 255 260acc gaa gcc ggt gac ggt att acc att atc aac atc ggt gtg ggc cca 931Thr Glu Ala Gly Asp Gly Ile Thr Ile Ile Asn Ile Gly Val Gly Pro

265 270 275tcc aat gca aaa act atc acc gac tgc ctt gct gtg ctc cgc cca gaa 979Ser Asn Ala Lys Thr Ile Thr Asp Cys Leu Ala Val Leu Arg Pro Glu

280 285 290gcc tgg gtg atg atc ggc cac tgt gct ggc atg gac gcc cgc atg cgc 1027Ala Trp Val Met Ile Gly His Cys Ala Gly Met Asp Ala Arg Met Arg

295 300 305atc ggc gac ctc atc ctt ggc aac gcc tac cag cgc gaa gac cac att 1075Ile Gly Asp Leu Ile Leu Gly Asn Ala Tyr Gln Arg Glu Asp His Ile310 315 320 325ctg aat acc cgc atc cca ctt ggt aat ccg atc ccg gca ata cca gaa 1123Leu Asn Thr Arg Ile Pro Leu Gly Asn Pro Ile Pro Ala Ile Pro Glu

330 335 340atc caa aaa gct cta gaa gcc agc gtc gac gaa atc tac gga tcc 1168Ile Gln Lys Ala Leu Glu Ala Ser Val Asp Glu Ile Tyr Gly Ser

345350355 tagtattcta tagtgtcacc taa 1191<210>972<211>356<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>972Val Gln Lys Asp Ser Val Val Arg Met Glu Ala Thr Thr Ile Asp Asp 151015 Ala Ile Ala Lys Leu Ile AspIle Tyr Asp Thr Ser Thr Lys Leu Ala

20 25 30Lys Glu Thr Leu Asn Asn Glu Asp Tyr Ala Ala Tyr Ala Asp Val Val

35 40 45Tyr Pro Lys Leu Thr Val Asp Val Leu Glu Trp Lys Pro Ile Asp Arg

50 55 60Thr Glu Pro Phe Gly Tyr Val Asp Arg Ala Gly Arg Tyr Ser Ala Thr 65 70 75 80Leu Ser Lys Pro Arg Val Ile Glu Arg Tyr Leu Arg Glu Gln Leu Glu

85 90 95Arg Leu Thr Ser Asn Tyr Pro Cys Lys Ile Tyr Val Ser Glu Ser Asp

100 105 110Ile Arg Ile Pro Pro Glu Tyr Ile Arg Gly Ala Pro Ser Ala Thr Glu

115 120 125Ala Arg Arg Ala Gly Asp Val Ala Asp Ile Ile Pro Arg Pro Thr Leu

130 135 140Asp Glu Val His Asp Ala Ile Ile Asp Gly Asp Trp His Ala Phe Asn145 150 155 160Gly Pro Glu Leu Pro Leu Phe His Phe Gly Pro Gln Arg Phe Asp Ile

165 170 175Ala Cys Ala Arg Ile Glu His Tyr Thr Gly Ile Asn Val Glu His Val

180 185 190Gln Lys Tyr Ile Leu Phe Thr Asn Tyr Ala Met His Thr Thr Glu Phe

195 200 205Val His Phe Ala Met Ser Glu Leu Thr Ser Glu Asp Ser Arg Tyr Val

210 215 220Gly Leu Ser Leu Pro Asn Gly Gln Val Ile Asp Arg Glu Thr Ala Thr225 230 235 240Ser Leu Gly Thr Glu Thr LeuAsp Leu Thr Ser Arg Phe Gln Met Pro

245 250 255Arg Tyr Asp Leu Ile Thr Glu Ala Gly Asp Gly Ile Thr Ile Ile Asn

260 265 270Ile Gly Val Gly Pro Ser Asn Ala Lys Thr Ile Thr Asp Cys Leu Ala

275 280 285Val Leu Arg Pro Glu Ala Trp Val Met Ile Gly His Cys Ala Gly Met

290 295 300Asp Ala Arg Met Arg Ile Gly Asp Leu Ile Leu Gly Asn Ala Tyr Gln305 310 315 320Arg Glu Asp His Ile Leu Asn Thr Arg Ile Pro Leu Gly Asn Pro Ile

325 330 335Pro Ala Ile Pro Glu Ile Gln Lys Ala Leu Glu Ala Ser Val Asp Glu

340 345 350Ile Tyr Gly Ser

355<210>973<211>1302<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1279)<223>RXA00l47<400>973attgcatata atgcaatgaa ttgaataaac tacattcagg gttatcaacc agccaatttc 60ttttaaaaag gcagacacac gaaaggcgac aacagtcacc gtg agt aaa gac acc 115

Val Ser Lys Asp Thr

1 5 acc acc tac cag gga gtc acc gag atc gga tcc gtt ccg gca tac ctg 163Thr Thr Tyr Gln Gly Val Thr Glu Ile Gly Ser Val Pro Ala Tyr Leu

10 15 20gtt ctt gca gac gga cgt acc ttc acc gga ttt ggc ttt gga gct atc 211Val Leu Ala Asp Gly Arg Thr Phe Thr Gly Phe Gly Phe Gly Ala Ile

25 3035ggc acc acc ctt ggt gag gca gtg ttc act acc gcc atg acc ggt tac 259Gly Thr Thr Leu Gly Glu Ala Val Phe Thr Thr Ala Met Thr Gly Tyr

40 45 50caa gaa acc atg acc gat cct tcc tat cac cgc cag att gtt gtg gct 307Gln Glu Thr Met Thr Asp Pro Ser Tyr His Arg Gln Ile Val Val Ala

55 60 65acc gca cca cag atc ggc aac acc ggc tgg aac gat gag gac aac gag 355Thr Ala Pro Gln Ile Gly Asn Thr Gly Trp Asn Asp Glu Asp Asn Glu 70 75 80 85tcc cgc gac ggc aag att tgg gtt gca ggc ctt gtt atc cgc gac ctc 403Ser Arg Asp Gly Lys Ile Trp Val Ala Gly Leu Val Ile Arg Asp Leu

90 95 100gca gca cgt gtg tcc aac tgg cgc gcc acc acc tcc ttg cag cag gaa 451Ala Ala Arg Val Ser Asn Trp Arg Ala Thr Thr Ser Leu Gln Gln Glu

105 110 115atg gca ggc cag ggc atc gtc ggc atc ggc gga atc gac acc cgc gca 499Met Ala Gly Gln Gly Ile Val Gly Ile Gly Gly Ile Asp Thr Arg Ala

120 125 130ctg gtt cgc cac ctg cgc aat gaa ggt tcc att gca gcg ggc atc ttc 547Leu Val Arg His Leu Arg Asn Glu Gly Ser Ile Ala Ala Gly Ile Phe

135 140 145tcc ggc gct gac gca cag cgc cca gtt gaa gaa ctc gta gag atc gtc 595Ser Gly Ala Asp Ala Gln Arg Pro Val Glu Glu Leu Val Glu Ile Val150 155 160 165aag aat cag cca gca atg acc ggc gca aac ctc tcc gtt gag gtc tct 643Lys Asn Gln Pro Ala Met Thr Gly Ala Asn Leu Ser Val Glu Val Ser

170 175 180gct gat gaa acc tac gtc atc gaa gct gaa ggc gaa gag cgc cac acc 691Ala Asp Glu Thr Tyr Val Ile Glu Ala Glu Gly Glu Glu Arg His Thr

185 190 195gtc gtg gcc tac gac ctg ggc att aag caa aac acc cca cgt cgt ttc 739Val Val Ala Tyr Asp Leu Gly Ile Lys Gln Asn Thr Pro Arg Arg Phe

200 205 210tct gca cgc ggt gtt cgc acc gtc atc gtg cct gct gaa acc cca ttc 787Ser Ala Arg Gly Val Arg Thr Val Ile Val Pro Ala Glu Thr Pro Phe

215 220 225gag gat atc aag cag tac aac cca tca ggc gtg ttc atc tcc aac ggc 835Glu Asp Ile Lys Gln Tyr Asn Pro Ser Gly Val Phe Ile Ser Asn Gly230 235 240 245cct ggc gat cct gca gca gca gac gtc atg gtt gat atc gtc cgc gaa 883Pro Gly Asp Pro Ala Ala Ala Asp Val Met Val Asp Ile Val Arg Glu

250 255 260gtt ctt gaa gcc gac att cca ttc ttt ggc atc tgc ttc ggc aac cag 931Val Leu Glu Ala Asp Ile Pro Phe Phe Gly Ile Cys Phe Gly Asn Gln

265 270 275att ctt ggc cgc gca ttc ggc atg gag acc tac aag ctg aag ttc ggc 979Ile Leu Gly Arg Ala Phe Gly Met Glu Thr Tyr Lys Leu Lys Phe Gly

280 285 290cac cgc ggc atc aac gtt cca gtg aag aac cac atc acc ggc aag atc 1027His Arg Gly Ile Asn Val Pro Val Lys Asn His Ile Thr Gly Lys Ile

295 300 305gac atc acc gcc cag aac cac ggc ttc gca ctc aag ggt gaa gca ggc 1075Asp Ile Thr Ala Gln Asn His Gly Phe Ala Leu Lys Gly Glu Ala Gly310 315 320 325cag gaa ttc gag acc gat ttc ggc act gca att gtc acc cac acc tgc 1123Gln Glu Phe Glu Thr Asp Phe Gly Thr Ala Ile Val Thr His Thr Cys

330 335 340ctc aac gac ggc gtc gtt gaa ggt att gcg ctg aag tcc gga cgc gca 1171Leu Asn Asp Gly Val Val Glu Gly Ile Ala Leu Lys Ser Gly Arg Ala

345 350 355tac tcc gtt cag tac cac cca gag gcc gct gcc ggc cca aat gat gca 1219Tyr Ser Val Gln Tyr His Pro Glu Ala Ala Ala Gly Pro Asn Asp Ala

360 365 370agc ccc ctg ttt gac cag ttt gtt gag ctg atg gat gca gac gct cag 1267Ser Pro Leu Phe Asp Gln Phe Val Glu Leu Met Asp Ala Asp Ala Gln

375380385 aag aaa ggc gca taaataacat gccaaagcgt tca 1302Lys Lys Gly Ala390<210>974<211>393<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>974Val Ser Lys Asp Thr Thr Thr Tyr Gln Gly Val Thr Glu Ile Gly Ser 1510I 5Val Pro Ala Tyr Leu Val Leu Ala Asp Gly Arg Thr Phe Thr Gly Phe

20 25 30Gly Phe Gly Ala Ile Gly Thr Thr Leu Gly Glu Ala Val Phe Thr Thr

35 40 45Ala Met Thr Gly Tyr Gln Glu Thr Met Thr Asp Pro Ser Tyr His Arg

50 55 60Gln Ile Val Val Ala Thr Ala Pro Gln Ile Gly Asn Thr Gly Trp Asn 65 70 75 80Asp Glu Asp Asn Glu Ser Arg Asp Gly Lys Ile Trp Val Ala Gly Leu

85 90 95Val Ile Arg Asp Leu Ala Ala Arg Val Ser Asn Trp Arg Ala Thr Thr

100 105 110Ser Leu Gln Gln Glu Met Ala Gly Gln Gly Ile Val Gly Ile Gly Gly

115 120 125Ile Asp Thr Arg Ala Leu Val Arg His Leu Arg Asn Glu Gly Ser Ile

130 135 140Ala Ala Gly Ile Phe Ser Gly Ala Asp Ala Gln Arg Pro Val Glu Glu145 150 155 160Leu Val Glu Ile Val Lys Asn Gln Pro Ala Met Thr Gly Ala Asn Leu

165 170 175Ser Val Glu Val Ser Ala Asp Glu Thr Tyr Val Ile Glu Ala Glu Gly

180 185 190Glu Glu Arg His Thr Val Val Ala Tyr Asp Leu Gly Ile Lys Gln Asn

195 200 205Thr Pro Arg Arg Phe Ser Ala Arg Gly Val Arg Thr Val Ile Val Pro

210 215 220Ala Glu Thr Pro Phe Glu Asp Ile Lys Gln Tyr Asn Pro Ser Gly Val225 230 235 240Phe Ile Ser Asn Gly Pro Gly Asp Pro Ala Ala Ala Asp Val Met Val

245 250 255Asp Ile Val Arg Glu Val Leu Glu Ala Asp Ile Pro Phe Phe Gly Ile

260 265 270Cys Phe Gly Asn Gln Ile Leu Gly Arg Ala Phe Gly Met Glu Thr Tyr

275 280 285Lys Leu Lys Phe Gly His Arg Gly Ile Asn Val Pro Val Lys Asn His

290 295 300Ile Thr Gly Lys Ile Asp Ile Thr Ala Gln Asn His Gly Phe Ala Leu305 310 315 320Lys Gly Glu Ala Gly Gln Glu Phe Glu Thr Asp Phe Gly Thr Ala Ile

325 330 335 Val Thr His Thr Cys Leu Asn Asp Gly Val Val Glu Gly Ile Ala Leu

340 345 350Lys Ser Gly Arg Ala Tyr Ser Val Gln Tyr His Pro Glu AlaAla Ala

355 360 365Gly Pro Asn Asp Ala Ser Pro Leu Phe Asp Gln Phe Val Glu Leu Met

370375380 Asp Ala Asp Ala Gln Lys Lys Gly Ala 385390<210>975<211>1059<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1036)<223>RXA00145<400>975ccccaccgca cgcgcggaag acgtttccgt catgcttaca gaaatcgacg gccgcgatgc 60agtcacgctc acccgagaag actctgaagg ggattcctag atg aag cac ctc cta 115

Met Lys His Leu Leu

1 5tcc att agc gat ctt tcc aaa gat gag att gtt gga ttg ctg gat gaa 163Ser Ile Ser Asp Leu Ser Lys Asp Glu Ile Val Gly Leu Leu Asp Glu

10 15 20gcg gat cgc ttt aag gag gtg ctc gaa gga cgt gaa gta aag aag ctg 211Ala Asp Arg Phe Lys Glu Val Leu Glu Gly Arg Glu Val Lys Lys Leu

25 30 35ccc acg ctg cgt ggt cgc acc att ttt acc ttg ttc tat gag aac tcc 259Pro Thr Leu Arg Gly Arg Thr Ile Phe Thr Leu Phe Tyr Glu Asn Ser

40 45 50acg cgc acc cgt tcg tcc ttt gaa acc gca gga aag tgg atg age gcc 307Thr Arg Thr Arg Ser Ser Phe Glu Thr Ala Gly Lys Trp Met Ser Ala

55 60 65gat gtg att aac att tcg gcc tca tca tcc agc gtg aag aag ggc gag 355Asp Val Ile Asn Ile Ser Ala Ser Ser Ser Ser Val Lys Lys Gly Glu 70 75 80 85tcg ctg aaa gat acc ggc ttg act ttg tcg gca atc ggc gcg gat gcg 403Ser Leu Lys Asp Thr Gly Leu Thr Leu Ser Ala Ile Gly Ala Asp Ala

90 95 100atc atc atg cgc cac cca gcc tca ggc gcc gcg cag cag ctt gcg cag 451Ile Ile Met Arg His Pro Ala Ser Gly Ala Ala Gln Gln Leu Ala Gln

105 110 115ttc gtc gca cca ggt ggc aac ggc ccc agc gtg atc aac gcg ggt gac 499Phe Val Ala Pro Gly Gly Asn Gly Pro Ser Val Ile Asn Ala Gly Asp

120 125 130ggt tcg cac cag cac ccc acc cag gcg ctt ctc gac gct tta acc atc 547Gly Ser His Gln His Pro Thr Gln Ala Leu Leu Asp Ala Leu Thr Ile

135 140 145cgg cag cgc acc ggc cgc att gag gga ctc aaa gtt gtc atc gtg ggc 595Arg Gln Arg Thr Gly Arg Ile Glu Gly Leu Lys Val Val Ile Val Gly150 155 160 165 gac tgt ttg cac tcc cgg gtg gtg cgc tcc aat gtg gat ctg ctg tcc 643Asp Cys Leu His Ser Arg Val Val Arg Ser Asn Val Asp Leu Leu Ser

170 175 180act ttg ggc gca gag gta gtg ctg gtt gct cct ccg aca ctg ctt cct 691Thr Leu Gly Ala Glu Val Val Leu Val Ala Pro Pro Thr Leu Leu Pro

185 190 195att ggt gtg gag aac tgg cca gtc cga ttc tcc tac gac atg gac gca 739Ile Gly Val Glu Asn Trp Pro Val Arg Phe Ser Tyr Asp Met Asp Ala

200 205 210gaa att gcc gac gcc gac gta gtg atg atg ctg cgc gtt cag caa gaa 787Glu Ile Ala Asp Ala Asp Val Val Met Met Leu Arg Val Gln Gln Glu

215 220 225cgc atg cag ggt ggt ttc ttc ccc tca cac cgt gag tac gca acg ctg 835Arg Met Gln Gly Gly Phe Phe Pro Ser His Arg Glu Tyr Ala Thr Leu230 235 240 245tac ggc atg tcc aaa gag cgc gaa gct cgc ctc aag gac tcc gcc atc 883Tyr Gly Met Ser Lys Glu Arg Glu Ala Arg Leu Lys Asp Ser Ala Ile

250 255 260atc atg cac ccc ggc ccc atg ctt cgt ggc atg gaa att aac ttc cag 931Ile Met His Pro Gly Pro Met Leu Arg Gly Met Glu Ile Asn Phe Gln

265 270 275gtg gca gac gca cca cgc acc gcg gta ctg cag cag gta agc aac ggt 979Val Ala Asp Ala Pro Arg Thr Ala Val Leu Gln Gln Val Ser Ash Gly

280 285 290gtg cac atg cgc atg gcc att ttg ttc gcc ctg gtc gca ggc tct gac 1027Val His Met Arg Met Ala Ile Leu Phe Ala Leu Val Ala Gly Ser Asp

295300305 gcg act atc taatcgcgac catctgatcg cga 1059Ala Thr Ile310<210>976<21l>312<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>976Met Lys His Leu Leu Ser Ile Ser Asp Leu Ser Lys Asp Glu Ile Val 151015 Gly Leu Leu Asp Glu Ala Asp Arg Phe Lys Glu Val Leu Glu Gly Arg

20 25 30Glu Val Lys Lys Leu Pro Thr Leu Arg Gly Arg Thr Ile Phe Thr Leu

35 40 45Phe Tyr Glu Asn Ser Thr Arg Thr Arg Ser Ser Phe Glu Thr Ala Gly

50 55 60Lys Trp Met Ser Ala Asp Val Ile Asn Ile Ser Ala Ser Ser Ser Ser 65 70 75 80Val Lys Lys Gly Glu Ser Leu Lys Asp Thr Gly Leu Thr Leu Ser Ala

85 90 95Ile Gly Ala Asp Ala Ile Ile Met Arg His Pro Ala Ser Gly Ala Ala

100 105 110Gln Gln Leu Ala Gln Phe Val Ala Pro Gly Gly Asn Gly Pro Ser Val

115 120 125Ile Asn Ala Gly Asp Gly Ser His Gln His Pro Thr Gln Ala Leu Leu

130 135 140Asp Ala Leu Thr Ile Arg Gln Arg Thr Gly Arg Ile Glu Gly Leu Lys145 150 155 160Val Val Ile Val Gly Asp Cys Leu His Ser Arg Val Val Arg Ser Asn

165 170 175Val Asp Leu Leu Ser Thr Leu Gly Ala Glu Val Val Leu Val Ala Pro

180 185 190Pro Thr Leu Leu Pro Ile Gly Val Glu Asn Trp Pro Val Arg Phe Ser

195 200 205Tyr Asp Met Asp Ala Glu Ile Ala Asp Ala Asp Val Val Met Met Leu

210 215 220Arg Val Gln Gln Glu Arg Met Gln Gly Gly Phe Phe Pro Ser His Arg225 230 235 240Glu Tyr Ala Thr Leu Tyr Gly Met Ser Lys Glu Arg Glu Ala Arg Leu

245 250 255Lys Asp Ser Ala Ile Ile Met His Pro Gly Pro Met Leu Arg Gly Met

260 265 270Glu Ile Asn Phe Gln Val Ala Asp Ala Pro Arg Thr Ala Val Leu Gln

275 280 285Gln Val Ser Asn Gly Val His Met Arg Met Ala Ile Leu Phe Ala Leu

290295300 Val Ala Gly Ser Asp Ala Thr Ile 305310<210>977<211>1464<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1441)<223>RXA00l46<400>977atggccattt tgttcgccct ggtcgcaggc tctgacgcga ctatctaatc gcgaccatct 60gatcgcgaaa ttctagaaaa ggtaacgagg gattaaagaa gtg gtt gac agc aac 115

Val Val Asp Ser Asn

1 5acc cag tat cca gaa acc ggc gca ctg gca ccg gct cct gca gac tca 163Thr Gln Tyr Pro Glu Thr Gly Ala Leu Ala Pro Ala Pro Ala Asp Ser

10 15 20ctc cta atc agc aac gtt ttg gtc tac ggc gaa ggc gag cca acg aat 211Leu Leu Ile Ser Asn Val Leu Val Tyr Gly Glu Gly Glu Pro Thr Asn

25 30 35gtg ttt gtt aaa gat ggt gtg atc gca gct atc ggc ggc act cat gag 259Val Phe Val Lys Asp Gly Val Ile Ala Ala Ile Gly Gly Thr His Glu

40 45 50gct gac cgc acc atc gac ggc aat ggg gga gtt ctc ctt cca ggt ttc 307Ala Asp Arg Thr Ile Asp Gly Asn Gly Gly Val Leu Leu Pro Gly Phe

55 60 65gtg gac atg cac gtt cac ctg cgt gag cca ggc cgc gaa gac act gaa 355Val Asp Met His Val His Leu Arg Glu Pro Gly Arg Glu Asp Thr Glu 70 75 80 85acc att gcc act ggt tct gcc gcc gca gcc aag ggc gga ttc acc gca 403Thr Ile Ala Thr Gly Ser Ala Ala Ala Ala Lys Gly Gly Phe Thr Ala

90 95 100gta ttc acc atg gcg aac acc act cca gtg atg gat cag ccg gtt atc 451Val Phe Thr Met Ala Asn Thr Thr Pro Val Met Asp Gln Pro Val Ile

105 110 115gcg gaa tcc gta tgg ttc aag ggc caa aac att ggc ctg tgc gac gtg 499Ala Glu Ser Val Trp Phe Lys Gly Gln Asn Ile Gly Leu Cys Asp Val

120 125 130cat cca gtt gga tcc atc acc aag ggt ctt gag ggc aag gag ctt act 547His Pro Val Gly Ser Ile Thr Lys Gly Leu Glu Gly Lys Glu Leu Thr

135 140 145gag ttc ggc atg atg gct cgc tct gaa gcc aag gtg cgc atg ttc tct 595Glu Phe Gly Met Met Ala Arg Ser Glu Ala Lys Val Arg Met Phe Ser150 155 160 165gat gat ggc aag tgc gtc gat gat cct cag gtc atg cgc cgc gcg ctg 643Asp Asp Gly Lys Cys Val Asp Asp Pro Gln Val Met Arg Arg Ala Leu

170 175 180gaa tac gcc aag ggc atg gac gtt ttg atc gcc cag cac gct gag gat 691Glu Tyr Ala Lys Gly Met Asp Val Leu Ile Ala Gln His Ala Glu Asp

185 190 195cac cgc ctg act gag ggc gct tca gca cac gag ggt gaa aac gca gct 739His Arg Leu Thr Glu Gly Ala Ser Ala His Glu Gly Glu Asn Ala Ala

200 205 210cgt ctg ggt ctg cgc ggc tgg cca cgt gtg gct gag gaa tcc atc gtg 787Arg Leu Gly Leu Arg Gly Trp Pro Arg Val Ala Glu Glu Ser Ile Val

215 220 225gtg cgc gat gcc atc atg gct cgt gac tac ggc aac cgc gtg cac atc 835Val Arg Asp Ala Ile Met Ala Arg Asp Tyr Gly Asn Arg Val His Ile230 235 240 245tgc cac gcc tcc act gaa ggc acc gtg gag ttg ctt cgt tgg gct aag 883Cys His Ala Ser Thr Glu Gly Thr Val Glu Leu Leu Arg Trp Ala Lys

250 255 260tcc cag ggc att cca atc acc gcg gaa gtc acc ccg cac cac ctc acc 931Ser Gln Gly Ile Pro Ile Thr Ala Glu Val Thr Pro His His Leu Thr

265 270 275ttg acc gat gag cgc ctg gaa acc tac gac gcg gtc aac aaa gtc aat 979Leu Thr Asp Glu Arg Leu Glu Thr Tyr Asp Ala Val Asn Lys Val Asn

280 285290ccg cca ctg cgc gaa agc cgc gat gcc gaa gcg ctc aag aag gcg ctt 1027Pro Pro Leu Arg Glu Ser Arg Asp Ala Glu Ala Leu Lys Lys Ala Leu

295 300 305ctc gac ggc acc atc gat gtt gtt gca acc gac cac gct cct cac ggt 1075Leu Asp Gly Thr Ile Asp Val Val Ala Thr Asp His Ala Pro His Gly310 315 320 325tcc gaa gat aag tgc tgt gaa ttc gaa aac gcc aag cca ggc atg ctc 1123Ser Glu Asp Lys Cys Cys Glu Phe Glu Asn Ala Lys Pro Gly Met Leu

330 335 340gga ttg gaa acc tca ctg tcc atc atc gtg gac acc ttc gtt gcc acc 1171Gly Leu Glu Thr Ser Leu Ser Ile Ile Val Asp Thr Phe Val Ala Thr

345 350 355gga ctt gca gac tgg cgc ttt gtt gcg cgc gtg atg agt gaa cgc cca 1219Gly Leu Ala Asp Trp Arg Phe Val Ala Arg Val Met Ser Glu Arg Pro

360 365 370gca gaa atc acc cgt cta cca ggc cag ggt cgc cca atc gca gaa ggt 1267Ala Glu Ile Thr Arg Leu Pro Gly Gln Gly Arg Pro Ile Ala Glu Gly

375 380 385gag cca gca aac ctc gcg att gtt gat cca gga aaa acc tgg aca gca 1315Glu Pro Ala Asn Leu Ala Ile Val Asp Pro Gly Lys Thr Trp Thr Ala390 395 400 405tcc ggt gca gac ttt gcg tcc aag gct gaa aat acc cca ttt gag ggc 1363Ser Gly Ala Asp Phe Ala Ser Lys Ala Glu Asn Thr Pro Phe Glu Gly

410 415 420caa gaa ttc agt gcc aag gtc aca cac acc gtg ctt cgt ggc aag gtg 1411Gln Glu Phe Ser Ala Lys Val Thr His Thr Val Leu Arg Gly Lys Val

425 430 435act tgt gca gac gga gtt gca caa aac gct taacgggtgg gtgcatagta 1461Thr Cys Ala Asp Gly Val Ala Gln Asn Ala

440445 tgc 1464<210>978<211>447<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>978Val Val Asp Ser Asn Thr Gln Tyr Pro Glu Thr Gly Ala Leu Ala Pro 151015 Ala Pro Ala Asp Ser Leu Leu Ile Ser Asn Val Leu Val Tyr Gly Glu

20 25 30Gly Glu Pro Thr Asn Val Phe Val Lys Asp Gly Val Ile Ala Ala Ile

35 40 45Gly Gly Thr His Glu Ala Asp Arg Thr Ile Asp Gly Asn Gly Gly Val

50 55 60Leu Leu Pro Gly Phe Val Asp Met His Val His Leu Arg Glu Pro Gly65 70 75 80Arg Glu Asp Thr Glu Thr Ile Ala Thr Gly Ser Ala Ala Ala Ala Lys

85 90 95Gly Gly Phe Thr Ala Val Phe Thr Met Ala Asn Thr Thr Pro Val Met

100 105 110Asp Gln Pro Val Ile Ala Glu Ser Val Trp Phe Lys Gly Gln Asn Ile

115 120 125Gly Leu Cys Asp Val His Pro Val Gly Ser Ile Thr Lys Gly Leu Glu

130 135 140Gly Lys Glu Leu Thr Glu Phe Gly Met Met Ala Arg Ser Glu Ala Lys145 150 155 160Val Arg Met Phe Ser Asp Asp Gly Lys Cys Val Asp Asp Pro Gln Val

165 170 175Met Arg Arg Ala Leu Glu Tyr Ala Lys Gly Met Asp Val Leu Ile Ala

180 185 190Gln His Ala Glu Asp His Arg Leu Thr Glu Gly Ala Ser Ala His Glu

195 200205Gly Glu Asn Ala Ala Arg Leu Gly Leu Arg Gly Trp Pro Arg Val Ala

210 215 220Glu Glu Ser Ile Val Val Arg Asp Ala Ile Met Ala Arg Asp Tyr Gly225 230 235 240Asn Arg Val His Ile Cys His Ala Ser Thr Glu Gly Thr Val Glu Leu

245 250 255Leu Arg Trp Ala Lys Ser Gln Gly Ile Pro Ile Thr Ala Glu Val Thr

260 265 270Pro His His Leu Thr Leu Thr Asp Glu Arg Leu Glu Thr Tyr Asp Ala

275 280 285Val Asn Lys Val Asn Pro Pro Leu Arg Glu Ser Arg Asp Ala Glu Ala

290 295 300Leu Lys Lys Ala Leu Leu Asp Gly Thr Ile Asp Val Val Ala Thr Asp305 310 315 320His Ala Pro His Gly Ser Glu Asp Lys Cys Cys Glu Phe Glu Asn Ala

325 330 335Lys Pro Gly Met Leu Gly Leu Glu Thr Ser Leu Ser Ile Ile Val Asp

340 345 350Thr Phe Val Ala Thr Gly Leu Ala Asp Trp Arg Phe Val Ala Arg Val

355 360 365Met Ser Glu Arg Pro Ala Glu Ile Thr Arg Leu Pro Gly Gln Gly Arg

370 375 380Pro Ile Ala Glu Gly Glu Pro Ala Asn Leu Ala Ile Val Asp Pro Gly385 390 395 400Lys Thr Trp Thr Ala Ser Gly Ala Asp Phe Ala Ser Lys Ala Glu Asn

405 410 415Thr Pro Phe Glu Gly Gln Glu Phe Ser Ala Lys Val Thr His Thr Val

420 425 430Leu Arg Gly Lys Val Thr Cys Ala Asp Gly Val Ala Gln Asn Ala

435440445<210>979<211>1025<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) } (1002)<223>RXA02208<400>979ctc gga gtc gtc gac ggc gtc gca cct cta aac cgc acc atg gaa aaa 48Leu Gly Val Val Asp Gly Val Ala Pro Leu Asn Arg Thr Met Glu Lys 151015 atc atc gca gtg cac gat gat tcc ctc tcc cag gaa gtc ttc ggc gtc 96Ile Ile Ala Val His Asp Asp Ser Leu Ser Gln Glu Val Phe Gly Val

20 25 30acc ttc cca cga cca cta ggc ctc gcc gca ggt ttc gac aaa aac gca 144Thr Phe Pro Arg Pro Leu Gly Leu Ala Ala Gly Phe Asp Lys Asn Ala

35 40 45tca atg gct gat gcc tgg ggt gcc gtt gga ttc gga tac gcc gaa ctt 192Ser Met Ala Asp Ala Trp Gly Ala Val Gly Phe Gly Tyr Ala Glu Leu

50 55 60ggc acc gtc acc gcc ttc cca cag cca gga aac ccc acc ccg cgc ctt 240Gly Thr Val Thr Ala Phe Pro Gln Pro Gly Asn Pro Thr Pro Arg Leu 65 70 75 80ttc cgc ctg cct gcc gac aaa gct atc ttg aac cgc atg gga ttc aac 288Phe Arg Leu Pro Ala Asp Lys Ala Ile Leu Asn Arg Met Gly Phe Asn

85 90 95aac ctg ggt gca gca gaa gtc gca aaa aac ctg cgc aac cgg aaa tcc 336Asn Leu Gly Ala Ala Glu Val Ala Lys Asn Leu Arg Asn Arg Lys Ser

l00 105 110acc gat gtc atc ggc atc aac atc ggt aaa acc aaa gtg gtt ccc gct 384Thr Asp Val Ile Gly Ile Asn Ile Gly Lys Thr Lys Val Val Pro Ala

115 120 125gaa cac gca gta gat gac tac cgc cgt tct gca tct ttg tta ggt gat 432Glu His Ala Val Asp Asp Tyr Arg Arg Ser Ala Ser Leu Leu Gly Asp

130 135 140ctt gct gat tac ctg gtt gtc aac gtt tcc tcc ccc aac act ccg ggt 480Leu Ala Asp Tyr Leu Val Val Asn Val Ser Ser Pro Asn Thr Pro Gly145 150 155 160ctc cgc gat ctg cag gct gtg gaa tct ttg cga cca atc ctc gcc gca 528Leu Arg Asp Leu Gln Ala Val Glu Ser Leu Arg Pro Ile Leu Ala Ala

165 170 175gtg cag gaa tcc acc acc gtc cca gtc ttg gtg aaa atc gca cca gac 576Val Gln Glu Ser Thr Thr Val Pro Val Leu Val Lys Ile Ala Pro Asp

180 185 190ctc tcc gac gaa gac atc gac gcc gta gct gac ctg gca gtt gag ctc 624Leu Ser Asp Glu Asp Ile Asp Ala Val Ala Asp Leu Ala Val Glu Leu

195 200 205aaa ctc gcc gga atc gta gcc acc aat acc acc att tcc cgc gaa ggc 672Lys Leu Ala Gly Ile Val Ala Thr Asn Thr Thr Ile Ser Arg Glu Gly

210 215 220ctc aac act cct tca ggt gaa gtc gaa gcc atg ggt gct ggc gga atc 720Leu Asn Thr Pro Ser Gly Glu Val Glu Ala Met Gly Ala Gly Gly Ile225 230 235 240tcc ggt gct cca gta gca gcc cga tct ttg gag gta ctc aag cgc ctc 768Ser Gly Ala Pro Val Ala Ala Arg Ser Leu Glu Val Leu Lys Arg Leu

245 250 255tac gca cgg gta ggc aaa gag atg gtg ttg atc tct gtc ggt ggc atc 816Tyr Ala Arg Val Gly Lys Glu Met Val Leu Ile Ser Val Gly Gly Ile

260 265 270agc acc cct gag caa gcc tgg gaa cgc atc acc tcc ggc gca acc ctt 864Ser Thr Pro Glu Gln Ala Trp Glu Arg Ile Thr Ser Gly Ala Thr Leu

275 280 285ctg cag gga tac acc cca ttc atc tac ggt ggc ccc gat tgg atc aga 912Leu Gln Gly Tyr Thr Pro Phe Ile Tyr Gly Gly Pro Asp Trp Ile Arg

290 295 300gat atc cac ctt ggt atc gcc aag cag ctg aaa gct cac ggt ctg cgc 960Asp Ile His Leu Gly Ile Ala Lys Gln Leu Lys Ala His Gly Leu Arg305 310 315 320aac atc gct gac gct gtg ggc agc gaa ttg gag tgg aag aac 1002Asn Ile Ala Asp Ala Val Gly Ser Glu Leu Glu Trp Lys Asn

325330 taaacagacc aaacacacgt gcc 1025<210>980<211>334<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>980Leu Gly Val Val Asp Gly Val Ala Pro Leu Asn Arg Thr Met Glu Lys 151015 Ile Ile Ala Val His Asp Asp Ser Leu Ser Gln Glu Val Phe Gly Val

20 25 30Thr Phe Pro Arg Pro Leu Gly Leu Ala Ala Gly Phe Asp Lys Asn Ala

35 40 45Ser Met Ala Asp Ala Trp Gly Ala Val Gly Phe Gly Tyr Ala Glu Leu

50 55 60Gly Thr Val Thr Ala Phe Pro Gln Pro Gly Asn Pro Thr Pro Arg Leu 65 70 75 80Phe Arg Leu Pro Ala Asp Lys Ala Ile Leu Asn Arg Met Gly Phe Asn

85 90 95Asn Leu Gly Ala Ala Glu Val Ala Lys Asn Leu Arg Asn Arg Lys Ser

100 105 110Thr Asp Val Ile Gly Ile Asn Ile Gly Lys Thr Lys Val Val Pro Ala

115 120 125Glu His Ala Val Asp Asp Tyr Arg Arg Ser Ala Ser Leu Leu Gly Asp

130135 140Leu Ala Asp Tyr Leu Val Val Asn Val Ser Ser Pro Asn Thr Pro Gly145 150 155 160Leu Arg Asp Leu Gln Ala Val Glu Ser Leu Arg Pro Ile Leu Ala Ala

165 170 175Val Gln Glu Ser Thr Thr Val Pro Val Leu Val Lys Ile Ala Pro Asp

180 185 190Leu Ser Asp Glu Asp Ile Asp Ala Val Ala Asp Leu Ala Val Glu Leu

195 200 205Lys Leu Ala Gly Ile Val Ala Thr Asn Thr Thr Ile Ser Arg Glu Gly

210 215 220Leu Asn Thr Pro Ser Gly Glu Val Glu Ala Met Gly Ala Gly Gly Ile225 230 235 240Ser Gly Ala Pro Val Ala Ala Arg Ser Leu Glu Val Leu Lys Arg Leu

245 250 255Tyr Ala Arg Val Gly Lys Glu Met Val Leu Ile Ser Val Gly Gly Ile

260 265 270Ser Thr Pro Glu Gln Ala Trp Glu Arg Ile Thr Ser Gly Ala Thr Leu

275 280 285Leu Gln Gly Tyr Thr Pro Phe Ile Tyr Gly Gly Pro Asp Trp Ile Arg

290 295 300Asp Ile His Leu Gly Ile Ala Lys Gln Leu Lys Ala His Gly Leu Arg305 310 315 320Asn Ile Ala Asp Ala Val Gly Ser Glu Leu Glu Trp Lys Asn

325330<210>981<211>675<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<652>RXA01660<400>981gaaaactggt gtttttcggc cgtgtccacc ccaggttcta tgctgtaaca aacgcgggtt 60taaacctcaa tcatcaaatt agggaagggc tgggaaatcc atg tca tct aat tcc 115

Met Ser Ser Asn Ser

1 5att aac gca gaa gcg cgc gct gag ctt gct gaa ctg atc aaa gag cta 163Ile Asn Ala Glu Ala Arg Ala Glu Leu Ala Glu Leu Ile Lys Glu Leu

10 15 20gct gtc gtc cac ggt gaa gtc acc ttg tct tcg ggc aag aag gct gat 211Ala Val Val His Gly Glu Val Thr Leu Ser Ser Gly Lys Lys Ala Asp

25 30 35tac tac atc gat gtc cgt cgt gcc acc ttg cac gcg cgc gca tct cgc 259Tyr Tyr Ile Asp Val Arg Arg Ala Thr Leu His Ala Arg Ala Ser Arg

40 45 50ctg atc ggt cag ctg ctg cgc gaa gcc acc gct gac tgg gac tat gac 307Leu Ile Gly Gln Leu Leu Arg Glu Ala Thr Ala Asp Trp Asp Tyr Asp

55 60 65gca gtt ggc ggc ctg acc ttg ggc gct gac ccg gtt gcc acc gcc atc 355Ala Val Gly Gly Leu Thr Leu Gly Ala Asp Pro Val Ala Thr Ala Ile 70 75 80 85atg cac gcc gac ggc cgc gat atc aac gcg ttt gtg gtg cgc aag gag 403Met His Ala Asp Gly Arg Asp Ile Asn Ala Phe Val Val Arg Lys Glu

90 95 100gcc aag aag cac ggc atg cag cgt cgc att gag ggc cct gac ctg acg 451Ala Lys Lys His Gly Met Gln Arg Arg Ile Glu Gly Pro Asp Leu Thr

105 110 115ggc aag aag gtg ctc gtg gtg gaa gat acc acc acc acc gga aat tcc 499Gly Lys Lys Val Leu Val Val Glu Asp Thr Thr Thr Thr Gly Asn Ser

120 125 130cct ctg aca gct gtt gcc gcg ttg cgt gaa gct ggc att gag gtt gtg 547Pro Leu Thr AlaVal Ala Ala Leu Arg Glu Ala Gly Ile Glu Val Val

135 140 145ggc gtt gcc acc gtg gtc gat cgc gca acc ggt gca gat gag gtt atc 595Gly Val Ala Thr Val Val Asp Arg Ala Thr Gly Ala Asp Glu Val Ile150 155 160 165gca gcg gaa ggc ctt cct tac cgc agc ttg ctg gga ctt tct gat ctt 643Ala Ala Glu Gly Leu Pro Tyr Arg Ser Leu Leu Gly Leu Ser Asp Leu

170175180 gga ctc aac taacaccccc ggccccacgg agt 675Gly Leu Asn<210>982<211>184<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>982Met Ser Ser Asn Ser Ile Asn Ala Glu Ala Arg Ala Glu Leu Ala Glu 151015 Leu Ile Lys Glu Leu Ala Val Val His Gly Glu Val Thr Leu Ser Ser

20 25 30Gly Lys Lys Ala Asp Tyr Tyr Ile Asp Val Arg Arg Ala Thr Leu His

35 40 45Ala Arg Ala Ser Arg Leu Ile Gly Gln Leu Leu Arg Glu Ala Thr Ala

50 55 60Asp Trp Asp Tyr Asp Ala Val Gly Gly Leu Thr Leu Gly Ala Asp Pro 65 70 75 80Val Ala Thr Ala Ile Met His Ala Asp Gly Arg Asp Ile Asn Ala Phe

85 90 95Val Val Arg Lys Glu Ala Lys Lys His Gly Met Gln Arg Arg Ile Glu

100 105 110Gly Pro Asp Leu Thr Gly Lys Lys Val Leu Val Val Glu Asp Thr Thr

115 120 125Thr Thr Gly Asn Ser Pro Leu Thr Ala Val Ala Ala Leu Arg Glu Ala

130 135 140Gly Ile Glu Val Val Gly Val Ala Thr Val Val Asp Arg Ala Thr Gly145 150155 160Ala Asp Glu Val Ile Ala Ala Glu Gly Leu Pro Tyr Arg Ser Leu Leu

165 170 175Gly Leu Ser Asp Leu Gly Leu Asn

180<210>983<211>957<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<934)<223>RXA02235<400>983gtgtcaccgc agctgtccag ggcatagagg ccctgcgtga gggcgttgtc agcgtccgcg 60cgctgcagga actcgaccac gcagtcaagg cttaagccct atg aca ttc ggc gag 115

Met Thr Phe Gly Glu

1 5aag ctt ctg aac gcc gcc tcc acc cgt ggc agg cta tgc gtg ggc att 163Lys Leu Leu Asn Ala Ala Ser Thr Arg Gly Arg Leu Cys Val Gly Ile

10 15 20gat ccc cac gaa agc ctg ctg acg tcc tgg ggg ctg ecg gta aac gta 211Asp Pro His Glu Ser Leu Leu Thr Ser Trp Gly Leu Pro Val Asn Val

25 30 35gac gga ctt gcg gag ttc tcc cgc gcc tgc gtg gag gct ttc gcc gac 259Asp Gly Leu Ala Glu Phe Ser Arg Ala Cys Val Glu Ala Phe Ala Asp

40 45 50acc gtg gca ttg gtg aag cct cag gtg gcg ttc tat gag cgt tte ggt 307Thr Val Ala Leu Val Lys Pro Gln Val Ala Phe Tyr Glu Arg Phe Gly

55 60 65tcc gct ggc ttt gcc atc ttg gaa gaa acc att cag acg ctg cgt gag 355Ser Ala Gly Phe Ala Ile Leu Glu Glu Thr Ile Gln Thr Leu Arg Glu 70 75 80 85cgt ggc tgt ttg gtg gte tct gac gcc aaa cgc ggc gat att ggc tcc 403Arg Gly Cys Leu Val Val Ser Asp Ala Lys Arg Gly Asp Ile Gly Ser

90 95 100acc atg gct ggc tat gcc tea gcg tgg tta gat cca gcg tca ccg ctg 451Thr Met Ala Gly Tyr Ala Ser Ala Trp Leu Asp Pro Ala Ser Pro Leu

105 110 115tct agc gac gct gtg acg gte tct ccc tac ctt ggt ttt cat tcc ttg 499Ser Ser Asp Ala Val Thr Val Ser Pro Tyr Leu Gly Phe His Ser Leu

120 125 130gac cca gtg ttc gaa ctt gcc gag caa cac ggc agg gga gtg ttt gtc 547Asp Pro Val Phe Glu Leu Ala Glu Gln His Gly Arg Gly Val Phe Val

135 140 145ttg gcc gcg acc tca aac cct gag gcc cgc gaa ctc cag gac cag caa 595Leu Ala Ala Thr Ser Asn Pro Glu Ala Arg Glu Leu Gln Asp Gln Gln150 155 160 165aac gct gac ggc gtg agc att tcc cag cag atc gtg gat cag gca gcg 643Asn Ala Asp Gly Val Ser Ile Ser Gln Gln Ile Val Asp Gln Ala Ala

170 175 180gcg ctt aac gcg cct tat atg gcc cag ggc aag gct ggc aac att ggc 691Ala Leu Asn Ala Pro Tyr Met Ala Gln Gly Lys Ala Gly Asn Ile Gly

185 190 195gtc gtc atc ggc gcc acc ttg tcc aaa cca cca cgc tta tcg acg ctc 739Val Val Ile Gly Ala Thr Leu Ser Lys Pro Pro Arg Leu Ser Thr Leu

200 205 210ggg ggc gcc att ttg atg ccc ggc gtc ggc gcc cag ggc ggc acg gca 787Gly Gly Ala Ile Leu Met Pro Gly Val Gly Ala Gln Gly Gly Thr Ala

215 220 225agc gac gtt gat gag att gcg gga gac atg gct cat ctt gca ttc cca 835Ser Asp Val Asp Glu Ile Ala Gly Asp Met Ala His Leu Ala Phe Pro230 235 240 245aat gtc tct aga agt att ttg gcg acaggc cca gat atc gct gaa atg 883Asn Val Ser Arg Ser Ile Leu Ala Thr Gly Pro Asp Ile Ala Glu Met

250 255 260aag aat tct gtg gca aaa aat gct gca gac ttt cct ggt ttc ccc agg 931Lys Asn Ser Val Ala Lys Asn Ala Ala Asp Phe Pro Gly Phe Pro Arg

265270275 tca tagtcgcgga aacggccctt aat 957Ser<210>984<211>278<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>984Met Thr Phe Gly Glu Lys Leu Leu Asn Ala Ala Ser Thr Arg Gly Arg 151015 Leu Cys Val Gly Ile Asp Pro His Glu Ser Leu Leu Thr Ser Trp Gly

20 25 30Leu Pro Val Asn Val Asp Gly Leu Ala Glu Phe Ser Arg Ala Cys Val

35 40 45Glu Ala Phe Ala Asp Thr Val Ala Leu Val Lys Pro Gln Val Ala Phe

50 55 60Tyr Glu Arg Phe Gly Ser Ala Gly Phe Ala Ile Leu Glu Glu Thr Ile 65 70 75 80Gln Thr Leu Arg Glu Arg Gly Cys Leu Val Val Ser Asp Ala Lys Arg

85 90 95Gly Asp Ile Gly Ser Thr Met Ala Gly Tyr Ala Ser Ala Trp Leu Asp

100 105 110Pro Ala Ser Pro Leu Ser Ser Asp Ala Val Thr Val Ser Pro Tyr Leu

115 120 125Gly Phe His Ser Leu Asp Pro Val Phe Glu Leu Ala Glu Gln His Gly

130 135 140Arg Gly Val Phe Val Leu Ala Ala Thr Ser Asn Pro Glu Ala Arg Glu145 150 155 160Leu Gln Asp Gln Gln Asn Ala Asp Gly Val Ser Ile Ser Gln Gln Ile

165170 175Val Asp Gln Ala Ala Ala Leu Asn Ala Pro Tyr Met Ala Gln Gly Lys

180 185 190Ala Gly Asn Ile Gly Val Val Ile Gly Ala Thr Leu Ser Lys Pro Pro

195 200 205Arg Leu Ser Thr Leu Gly Gly Ala Ile Leu Met Pro Gly Val Gly Ala

210 215 220Gln Gly Gly Thr Ala Ser Asp Val Asp Glu Ile Ala Gly Asp Met Ala225 230 235 240His Leu Ala Phe Pro Asn Val Ser Arg Ser Ile Leu Ala Thr Gly Pro

245 250 255Asp Ile Ala Glu Met Lys Asn Ser Val Ala Lys Asn Ala Ala Asp Phe

260 265 270Pro Gly Phe Pro Arg Ser

275<210>985<211>852<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (829)<223>RXN01892<400>985ggtctcagtg gcttcttggt tgctgtgatt ttttcaaggc gtaccccgtg gccgatgtta 60aaagcggttg gcacaacccc tactgaagga gaacaccact gtg acc acc tcg agt 115

Val Thr Thr Ser Ser

1 5gaa caa ccc cgt aca gga tac aag cga gtg atg tta aag ctc gga ggt 163Glu Gln Pro Arg Thr Gly Tyr Lys Arg Val Met Leu Lys Leu Gly Gly

10 15 20gaa atg ttt ggt ggt ggc aaa gtc ggc gtc gat cct gat gta gta gac 211Glu Met Phe Gly Gly Gly Lys Val Gly Val Asp Pro Asp Val Val Asp

25 30 35aat gtt gca cgt cag atc gct gaa gtt gct aaa act gga gca gag att 259AsnVal Ala Arg Gln Ile Ala Glu Val Ala Lys Thr Gly Ala Glu Ile

40 45 50gcc gtt gtt atc ggt ggc gga aac ttc ttc cgc gga gct gag ctt cag 307Ala Val Val Ile Gly Gly Gly Asn Phe Phe Arg Gly Ala Glu Leu Gln

55 60 65cag cgt ggc atg gac cgc gca cgg tcc gat tac atg ggt atg ctc ggc 355Gln Arg Gly Met Asp Arg Ala Arg Ser Asp Tyr Met Gly Met Leu Gly 70 75 80 85aca gtc atg aac tgc ctc gcc ttg cag gac ttc ctc ggt cag cat ggc 403Thr Val Met Asn Cys Leu Ala Leu Gln Asp Phe Leu Gly Gln His Gly

90 95 100gtt gaa tgc cgt gtc cag acc gcc atc aac atg gca cag gtc gca gaa 451Val Glu Cys Arg Val Gln Thr Ala Ile Asn Met Ala Gln Val Ala Glu

105 110 115cca tat ctg cca ctg cgc gca gaa cgc cac ctg gaa aag ggc cgc gtt 499Pro Tyr Leu Pro Leu Arg Ala Glu Arg His Leu Glu Lys Gly Arg Val

120 125 130gtc atc ttc ggt gct ggc atg ggt atg ccg tac ttt tcc acg gac acc 547Val Ile Phe Gly Ala Gly Met Gly Met Pro Tyr Phe Ser Thr Asp Thr

135 140 145act gct gca cag cgt gcg ttg gaa atc ggc tgt gac gtc cta ctg atg 595Thr Ala Ala Gln Arg Ala Leu Glu Ile Gly Cys Asp Val Leu Leu Met150 155 160 165gct aag gct gtt gac ggt gtg tac agc gat gat cct cgt acc aac cca 643Ala Lys Ala Val Asp Gly Val Tyr Ser Asp Asp Pro Arg Thr Asn Pro

170 175 180gat gct gag ctc ttc acc gaa att act cca aag gaa gta att gag aag 691Asp Ala Glu Leu Phe Thr Glu Ile Thr Pro Lys Glu Val Ile Glu Lys

185 190 195ggc ctg aag gtt gcc gat gca act gca ttc agc ctc tgc atg gac aac 739Gly Leu Lys Val Ala Asp Ala Thr Ala Phe Ser Leu Cys Met Asp Asn

200 205 210aag atg cct atc ttg gtg ttt aac ctg ctt act gaa ggc aac att gct 787Lys Met Pro Ile Leu Val Phe Asn Leu Leu Thr Glu Gly Asn Ile Ala

215220225 cgc gcc atc agc ggt gaa cgt atc ggt act ctg gtc gag tcc 829Arg Ala Ile Ser Gly Glu Arg Ile Gly Thr Leu Val Glu Ser 230235240 tgatacatt agtcttataa aca 852<210>986<211>243<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>986Val Thr Thr Ser Ser Glu Gln Pro Arg Thr Gly Tyr Lys Arg Val Met 151015 Leu Lys Leu Gly Gly Glu Met Phe Gly Gly Gly Lys Val Gly Val Asp

20 25 30Pro Asp Val Val Asp Asn Val Ala Arg Gln Ile Ala Glu Val Ala Lys

35 40 45Thr Gly Ala Glu Ile Ala Val Val Ile Gly Gly Gly Asn Phe Phe Arg

50 55 60Gly Ala Glu Leu Gln Gln Arg Gly Met Asp Arg Ala Arg Ser Asp Tyr 65 70 75 80Met Gly Met Leu Gly Thr Val Met Asn Cys Leu Ala Leu Gln Asp Phe

85 90 95Leu Gly Gln His Gly Val Glu Cys Arg Val Gln Thr Ala Ile Asn Met

100 105 110Ala Gln Val Ala Glu Pro Tyr Leu Pro Leu Arg Ala Glu Arg His Leu

115 120 125Glu Lys Gly Arg Val Val Ile Phe Gly Ala Gly Met Gly Met Pro Tyr

130 135 140Phe Ser Thr Asp Thr Thr Ala Ala Gln Arg Ala Leu Glu Ile GlyCys145 150 155 160Asp Val Leu Leu Met Ala Lys Ala Val Asp Gly Val Tyr Ser Asp Asp

165 170 175Pro Arg Thr Asn Pro Asp Ala Glu Leu Phe Thr Glu Ile Thr Pro Lys

180 185 190Glu Val Ile Glu Lys Gly Leu Lys Val Ala Asp Ala Thr Ala Phe Ser

195 200 205Leu Cys Met Asp Asn Lys Met Pro Ile Leu Val Phe Asn Leu Leu Thr

210215220 Glu Gly Asn Ile Ala Arg Ala Ile Ser Gly Glu Arg Ile Gly Thr Leu 225230235240 ValGlu Ser<210>987<211>798<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(47) } (775)<223>FRXA01892<400>987atgttaaaag cggttggcac aacccctact gaaggagaac accacg gtg acc acc tcg 58

Val Thr Thr Ser

1agt gaa caa ccc cgt aca gga tac aaa cga gtg atg tta aag ctc gaa 106Ser Glu Gln Pro Arg Thr Gly Tyr Lys Arg Val Met Leu Lys Leu Glu 5 10 15 20ggt gaa atg ttt ggt ggt ggc aaa gtc ggc gtc gat cct gat gta gta 154Gly Glu Met Phe Gly Gly Gly Lys Val Gly Val Asp Pro Asp Val Val

25 30 35gac aat gtt gca cgt cag atc gct gaa gtt gct aaa act gga gca gag 202Asp Asn Val Ala Arg Gln Ile Ala Glu Val Ala Lys Thr Gly Ala Glu

40 45 50att gcc gtt gtt atc ggt ggc gga aac ttc ttc cgc gga gct gag ctt 250Ile Ala Val Val Ile Gly Gly Gly Asn Phe Phe Arg Gly Ala Glu Leu

55 60 65cag cag cgt ggc atg gac cgc gca cgg tcc gat tac atg ggt atg ctc 298Gln Gln Arg Gly Met Asp Arg Ala Arg Ser Asp Tyr Met Gly Met Leu

70 75 80ggc aca gtc atg aac tgc ctc gcc ttg cag gac ttc ctc ggt cag cat 346Gly Thr Val Met Asn Cys Leu Ala Leu Gln Asp Phe Leu Gly Gln His 85 90 95 100ggc gtt gaa tgc cgt gtc cag acc gcc atc aac atg gca cag gtc gca 394Gly Val Glu Cys Arg Val Gln Thr Ala Ile Asn Met Ala Gln Val Ala

105 110 115gaa cca tat ctg cca ctg cgc gca gaa cgc cac ctg gaa aag ggc cgc 442Glu Pro Tyr Leu Pro Leu Arg Ala Glu Arg His Leu Glu Lys Gly Arg

120 125 130gtt gtc atc ttc ggt gct ggc atg ggt atg ccg tac ttt tcc acg gac 490Val Val Ile Phe Gly Ala Gly Met Gly Met Pro Tyr Phe Ser Thr Asp

135 140 145acc act gct gca cag cgt gcg ttg gaa atc ggc tgt gac gtc cta ctg 538Thr Thr Ala Ala Gln Arg Ala Leu Glu Ile Gly Cys Asp Val Leu Leu

150 155 160atg gct aag gct gtt gac ggt gtg tac agc gat gat cct cgt acc aac 586Met Ala Lys Ala Val Asp Gly Val Tyr Ser Asp Asp Pro Arg Thr Asn165 170 175 180cca gat gct gag ctc ttc acc gaa att act cca aag gaa gta att gag 634Pro Asp Ala Glu Leu Phe Thr Glu Ile Thr Pro Lys Glu Val Ile Glu

185 190 195aag ggc ctg aag gtt gcc gat gca act gca ttc agc ctc tgc atg gac 682Lys Gly Leu Lys Val Ala Asp Ala Thr Ala Phe Ser Leu Cys Met Asp

200 205 210aac aag atg cct atc ttg gtg ttt aac ctg ctt act gaa ggc aac att 730Asn Lys Met Pro Ile Leu Val Phe Asn Leu Leu Thr Glu Gly Asn Ile

215 220 225gct cgc gcc atc agc ggt gaa cgt atc ggt act ctg gtc gag tcc 775Ala Arg Ala Ile Ser Gly Glu Arg Ile Gly Thr Leu Val Glu Ser

230235240 tgatacattt agtcttataa aca 798<210>988<211>243<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>988Val Thr Thr Ser Ser Glu Gln Pro Arg Thr Gly Tyr Lys Arg Val Met 151015 Leu Lys Leu Glu Gly Glu Met Phe Gly Gly Gly Lys Val Gly Val Asp

20 25 30Pro Asp Val Val Asp Asn Val Ala Arg Gln Ile Ala Glu Val Ala Lys

35 40 45Thr Gly Ala Glu Ile Ala Val Val Ile Gly Gly Gly Asn Phe Phe Arg

50 55 60Gly Ala Glu Leu Gln Gln Arg Gly Met Asp Arg Ala Arg Ser Asp Tyr 65 70 75 80Met Gly Met Leu Gly Thr Val Met Asn Cys Leu Ala Leu Gln Asp Phe

85 90 95Leu Gly Gln His Gly Val Glu Cys Arg Val Gln Thr Ala Ile Asn Met

100 105 110Ala Gln Val Ala Glu Pro Tyr Leu Pro Leu Arg Ala Glu Arg His Leu

115 120 125Glu Lys Gly Arg Val Val Ile Phe Gly Ala Gly Met Gly Met Pro Tyr

130 135 140Phe Ser Thr Asp Thr Thr Ala Ala Gln Arg Ala Leu Glu Ile Gly Cys145 150 155 160Asp Val Leu Leu Met Ala Lys Ala Val Asp Gly Val Tyr Ser Asp Asp

165 170175Pro Arg Thr Asn Pro Asp Ala Glu Leu Phe Thr Glu Ile Thr Pro Lys

180 185 190Glu Val Ile Glu Lys Gly Leu Lys Val Ala Asp Ala Thr Ala Phe Ser

195 200 205Leu Cys Met Asp Asn Lys Met Pro Ile Leu Val Phe Asn Leu Leu Thr

210215220 Glu Gly Asn Ile Ala Arg Ala Ile Ser Gly Glu Arg Ile Gly Thr Leu 225230235240 ValGlu Ser<210>989<211>798<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (775)<223>RXA00105<400>989catcttgatc tgtcgccctg aacttgcaga tgaacttctc gagatgtgcg cgaagttcta 60cgaggagaat ggaacttact aacgctgtta tgatgacggc atg act gtt cca acg 115

Met Thr Val Pro Thr

1 5cct tat gaa gac ctt ctt cgg aag att gct gaa gaa ggg tcc cac aag 163Pro Tyr Glu Asp Leu Leu Arg Lys Ile Ala Glu Glu Gly Ser His Lys

10 15 20gac gac cgc acc ggc acc ggc act act tct tta ttc gga caa caa atc 211Asp Asp Arg Thr Gly Thr Gly Thr Thr Ser Leu Phe Gly Gln Gln Ile

25 30 35cgc ttt gat ctc aat gaa ggt ttt ccc ctt ctg acc acc aag aag gtc 259Arg Phe Asp Leu Asn Glu Gly Phe Pro Leu Leu Thr Thr Lys Lys Val

40 45 50cat ttc cac tct gtt gtg ggt gag ctt ttg tgg ttc ctt cag ggg gat 307His Phe His Ser Val Val Gly Glu Leu Leu Trp Phe Leu Gln Gly Asp

55 60 65tcc aac gtc aaa tgg ctg cag gat aac aac atc cgc att tgg aat gaa 355Ser Asn Val Lys Trp Leu Gln Asp Asn AsnIle Arg Ile Trp Asn Glu 70 75 80 85tgg gca gat gag gac ggc gag ctg ggc cct gtt tat ggt gtc cag tgg 403Trp Ala Asp Glu Asp Gly Glu Leu Gly Pro Val Tyr Gly Val Gln Trp

90 95 100cgt tct tgg cca acc cct gat ggt cgt cac att gac cag atc tca ggt 451Arg Ser Trp Pro Thr Pro Asp Gly Arg His Ile Asp Gln Ile Ser Gly

105 110 115gct tta gaa act ctg cga aac aac cct gat tca cgt cgc aat att gtc 499Ala Leu Glu Thr Leu Arg Asn Asn Pro Asp Ser Arg Arg Asn Ile Val

120 125 130tcg gcg tgg aat gtt tcc gag ctt gaa aac atg gct ctt ccc cct tgt 547Ser Ala Trp Asn Val Ser Glu Leu Glu Asn Met Ala Leu Pro Pro Cys

135 140 145cac ttg ctt ttc cag ctc tat gtc gcc gat ggc aaa ctg tct tgc cag 595His Leu Leu Phe Gln Leu Tyr Val Ala Asp Gly Lys Leu Ser Cys Gln150 155 160 165ctc tac cag cgt tct gcg gac atg ttc ctg ggt gtg cct ttc aac atc 643Leu Tyr Gln Arg Ser Ala Asp Met Phe Leu Gly Val Pro Phe Asn Ile

170 175 180gca tct tat gca ctg ctc acc cac atg ttt gcc cag cag gca ggc ttg 691Ala Ser Tyr Ala Leu Leu Thr His Met Phe Ala Gln Gln Ala Gly Leu

185 190 195gaa gtc ggc gag ttc att tgg act ggc ggc gac tgc cac att tat gac 739Glu Val Gly Glu Phe Ile Trp Thr Gly Gly Asp Cys His Ile Tyr Asp

200 205 210aac cac aag gaa cag gtc gcg gag cag ctg agc cga taagctcgcc 785Asn His Lys Glu Gln Val Ala Glu Gln Leu Ser Arg

215220225 cctaccccac ctt 798<210>990<211>225<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>990Met Thr Val Pro Thr Pro Tyr Glu Asp Leu Leu Arg Lys Ile Ala Glu 151015 Glu Gly Ser His Lys Asp Asp Arg Thr Gly Thr Gly Thr Thr Ser Leu

20 25 30Phe Gly Gln Gln Ile Arg Phe Asp Leu Asn Glu Gly Phe Pro Leu Leu

35 40 45Thr Thr Lys Lys Val His Phe His Ser Val Val Gly Glu Leu Leu Trp

50 55 60Phe Leu Gln Gly Asp Ser Asn Val Lys Trp Leu Gln Asp Asn Asn Ile 65 70 75 80Arg Ile Trp Asn Glu Trp Ala Asp Glu Asp Gly Glu Leu Gly Pro Val

85 90 95Tyr Gly Val Gln Trp Arg Ser Trp Pro Thr Pro Asp Gly Arg His Ile

100 105 110Asp Gln Ile Ser Gly Ala Leu Glu Thr Leu Arg Asn Asn Pro Asp Ser

115 120 125Arg Arg Asn Ile Val Ser Ala Trp Asn Val Ser Glu Leu Glu Asn Met

130 135 140Ala Leu Pro Pro Cys His Leu Leu Phe Gln Leu Tyr Val Ala Asp Gly145 150 155 160Lys Leu Ser Cys Gln Leu Tyr Gln Arg Ser Ala Asp Met Phe Leu Gly

165 170 175Val Pro Phe Asn Ile Ala Ser Tyr Ala Leu Leu Thr His Met Phe Ala

180 185 190Gln Gln Ala Gly Leu Glu Val Gly Glu Phe Ile Trp Thr Gly Gly Asp

195 200 205Cys His Ile Tyr Asp Asn His Lys Glu Gln Val Ala Glu Gln Leu Ser

210215220 Arg225<210>991<211>732<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (709)<223>RXA00131<400>991aggctctcgg cggtcagctc accgaactga ccaaggagca ggctgagtac atcggcgttg 60acgttgcagg cccattcaag ccggagcact accgctacta atg att gtc agc att 115

Met Ile Val Ser Ile

1 5gag gga atc gac ggc gcc ggc aaa aac acc ctg gtt tcg gca tta acg 163Glu Gly Ile Asp Gly Ala Gly Lys Asn Thr Leu Val Ser Ala Leu Thr

10 15 20cag gtt att gat gca aaa gtc ctt gca ttc cca cgt tat gaa acc tcg 211Gln Val Ile Asp Ala Lys Val Leu Ala Phe Pro Arg Tyr Glu Thr Ser

25 30 35att cac gcc caa ttg gcc gcg gaa gca ctc cac ggc cgc atg ggc gac 259Ile His Ala Gln Leu Ala Ala Glu Ala Leu His Gly Arg Met Gly Asp

40 45 50ctc acc gac agc gcc tac gcc atg gcc acg ctt ttc gcc ctc gac cgc 307Leu Thr Asp Ser Ala Tyr Ala Met Ala Thr Leu Phe Ala Leu Asp Arg

55 60 65cac ttc gcg att gat gac tta aat gcg ccc ggc gtg gtg ctg ctc gac 355His Phe Ala Ile Asp Asp Leu Asn Ala Pro Gly Val Val Leu Leu Asp 70 75 80 85cga tac gtc gcc tcc aac gcg gct tat acc gcc gcc aga ttg ctt gac 403Arg Tyr Val Ala Ser Asn Ala Ala Tyr Thr Ala Ala Arg Leu Leu Asp

90 95 100gac gac gcc ccc cgc tgg gtt gcc gac ctg gaa ttc ggg cgg ctt ggg 451Asp Asp Ala Pro Arg Trp Val Ala Asp Leu Glu Phe Gly Arg Leu Gly

105 110 115ctc cca cgt ccg acg ctt caa gtg ttg ttg gat acc ccc gcg gag gta 499Leu Pro Arg Pro Thr Leu Gln Val Leu Leu Asp Thr Pro Ala Glu Val

120 125 130gcg caa gat agg gct aga cgt cga gaa gcg ctt gac tcc gcg cgt gcg 547Ala Gln Asp Arg Ala Arg Arg Arg Glu Ala Leu Asp Ser Ala Arg Ala

135 140 145cgg gac cgc tat gaa tcg gat tcg gcg ctg cag caa cgc acc gcc gag 595Arg Asp Arg Tyr Glu Ser Asp Ser Ala Leu Gln Gln Arg Thr Ala Glu150 155 160 165cac tat cgc cgc ctc gcg gcg gac aac tgg gaa tca ccg tgg atc gtg 643His Tyr Arg Arg Leu Ala Ala Asp Asn Trp Glu Ser Pro Trp Ile Val

170 175 180gtt gcc cct gat gaa gac ccc ggc cac gtt gcg cag aga atc gtg gaa 691Val Ala Pro Asp Glu Asp Pro Gly His Val Ala Gln Arg Ile Val Glu

185 190 195ttc ctg ggt act ata aac taatcccaat tagcaggaag gat 732Phe Leu Gly Thr Ile Asn

200<210>992<211>203<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>992Met Ile Val Ser Ile Glu Gly Ile Asp Gly Ala Gly Lys Asn Thr Leu 151015 Val Ser Ala Leu Thr Gln Val Ile Asp Ala Lys Val Leu Ala Phe Pro

20 25 30Arg Tyr Glu Thr Ser Ile His Ala Gln Leu Ala Ala Glu Ala Leu His

35 40 45Gly Arg Met Gly Asp Leu Thr Asp Ser Ala Tyr Ala Met Ala Thr Leu

50 55 60Phe Ala Leu Asp Arg His Phe Ala Ile Asp Asp Leu Asn Ala Pro Gly 65 70 7580Val Val Leu Leu Asp Arg Tyr Val Ala Ser Asn Ala Ala Tyr Thr Ala

85 90 95Ala Arg Leu Leu Asp Asp Asp Ala Pro Arg Trp Val Ala Asp Leu Glu

100 105 110Phe Gly Arg Leu Gly Leu Pro Arg Pro Thr Leu Gln Val Leu Leu Asp

115 120 125Thr Pro Ala Glu Val Ala Gln Asp Arg Ala Arg Arg Arg Glu Ala Leu

130 135 140Asp Ser Ala Arg Ala Arg Asp Arg Tyr Glu Ser Asp Ser Ala Leu Gln145 150 155 160Gln Arg Thr Ala Glu His Tyr Arg Arg Leu Ala Ala Asp Asn Trp Glu

165 170 175Ser Pro Trp Ile Val Val Ala Pro Asp Glu Asp Pro Gly His Val Ala

180 185 190Gln Arg Ile Val Glu Phe Leu Gly Thr Ile Asn

195200<210>993<211>531<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (508)<223>RXA00266<400>993agtaggggat cgtccagcga agcggtcgca gaggctgtga ggaagctcta agtcgactta 60agtgcgcgaa gcagaccacc attaggtaga atcacccaac atg act gaa cgt act 115

Met Thr Glu Arg Thr

1 5ctc atc ctt atc aag cca gac ggt gtt acc aac gga cac gtc ggc gaa 163Leu Ile Leu Ile Lys Pro Asp Gly Val Thr Asn Gly His Val Gly Glu

10 15 20atc atc gca cgt att gag cgc aag ggc ctg aag ctc gct gct ctg gat 211Ile Ile Ala Arg Ile Glu Arg Lys Gly Leu Lys Leu Ala Ala Leu Asp

25 30 35ctg cgt gtt gca gac cgc gag acc gct gaa aag cac tac gaa gag cac 259Leu Arg Val Ala Asp Arg Glu Thr Ala Glu Lys His Tyr Glu Glu His

40 45 50gct gac aag cca ttc ttc ggt gag ctc gtt gaa ttc atc acc tct gca 307Ala Asp Lys Pro Phe Phe Gly Glu Leu Val Glu Phe Ile Thr Ser Ala

55 60 65cct ctg atc gca ggc atc gtc gaa ggc gag cgt gca atc gat gca tgg 355Pro Leu Ile Ala Gly Ile Val Glu Gly Glu Arg Ala Ile Asp Ala Trp 70 75 80 85cgt cag ctt gct ggt ggc acc gac cca gtt gct aag gca acc cca ggc 403Arg Gln Leu Ala Gly Gly Thr Asp Pro Val Ala Lys Ala Thr Pro Gly

90 95 100acc atc cgc ggc gat ttc gca ctg act gtt gga gag aac gtt gtt cac 451Thr Ile Arg Gly Asp Phe Ala Leu Thr Val Gly Glu Asn Val Val His

105 110 115ggt tct gat tcc cca gag tcc gct gag cgc gag atc tcc atc tgg ttc 499Gly Ser Asp Ser Pro Glu Ser Ala Glu Arg Glu Ile Ser Ile Trp Phe

120 125 130cct aac ctg taatttttac ggttagaaaa aaa 531Pro Asn Leu

135<210>994<211>136<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>994Met Thr Glu Arg Thr Leu Ile Leu Ile Lys Pro Asp Gly Val Thr Asn 151015 Gly His Val Gly Glu Ile Ile Ala Arg Ile Glu Arg Lys Gly Leu Lys

20 25 30Leu Ala Ala Leu Asp Leu Arg Val Ala Asp Arg Glu Thr Ala Glu Lys

35 40 45His Tyr Glu Glu His Ala Asp Lys Pro PhePhe Gly Glu Leu Val Glu

50 55 60Phe Ile Thr Ser Ala Pro Leu Ile Ala Gly Ile Val Glu Gly Glu Arg 65 70 75 80Ala Ile Asp Ala Trp Arg Gln Leu Ala Gly Gly Thr Asp Pro Val Ala

85 90 95Lys Ala Thr Pro Gly Thr Ile Arg Gly Asp Phe Ala Leu Thr Val Gly

100 105 110Glu Asn Val Val His Gly Ser Asp Ser Pro Glu Ser Ala Glu Arg Glu

115 120 125Ile Ser Ile Trp Phe Pro Asn Leu

130135<210>995<211>831<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (808)<223>RXA00718<400>995gcaccaagct gcacaccgtt cagcttggtg atcagaagcc aggttccctt cgtgcactga 60actcctctga gctgaccagc ttatacaagg tggtccaact gtg acg gaa att tcc 115

Val Thr Glu Ile Ser

1 5aac atg cct gcc ggt ggc ctc atc gta gcc atc gac ggg ccg tct ggc 163Asn Met Pro Ala Gly Gly Leu Ile Val Ala Ile Asp Gly Pro Ser Gly

10 15 20acc gga aaa tcc acc aca tcc cgc gcg ctc gca acc cgt ctc tcg gcc 211Thr Gly Lys Ser Thr Thr Ser Arg Ala Leu Ala Thr Arg Leu Ser Ala

25 30 35aag tac cta gat act ggt gcg atg tac cgc gtc gca acg ctt cat gtg 259Lys Tyr Leu Asp Thr Gly Ala Met Tyr Arg Val Ala Thr Leu His Val

40 45 50ctt aac cag ggg att gac cct gca gat agc gca gcc gtg atc gct gca 307Leu Asn Gln Gly Ile Asp Pro Ala Asp Ser Ala Ala Val Ile Ala Ala

55 60 65acc gct gta ttg ccg ttg tcg att tct gac gat ccc gcc tcc act gag 355Thr Ala Val Leu Pro Leu Ser Ile Ser Asp Asp Pro Ala Ser Thr Glu 70 75 80 85gtg ttg ctc gcg ggc gtc gat gtg caa aag gac atc cgc gga cca gaa 403Val Leu Leu Ala Gly Val Asp Val Gln Lys Asp Ile Arg Gly Pro Glu

90 95 100gtc acc caa aat gtc tcc gca gtg tcc gcg atc cct gag gtt cgt gaa 451Val Thr Gln Asn Val Ser Ala Val Ser Ala Ile Pro Glu Val Arg Glu

105 110 115aac ttg gtg gcg ttg cag cgc gca ctc gcc gcc aaa gca cat cgc tgc 499Asn Leu Val Ala Leu Gln Arg Ala Leu Ala Ala Lys Ala His Arg Cys

120 125 130gtc gtc gaa ggc aga gac atc gga acg gca gtg ctt gtc gac gcg ccc 547Val Val Glu Gly Arg Asp Ile Gly Thr Ala Val Leu Val Asp Ala Pro

135 140 145atc aag gcg ttt ctc acc gcc tca gcg gaa gtc cgc gcc cag cga cgc 595Ile Lys Ala Phe Leu Thr Ala Ser Ala Glu Val Arg Ala Gln Arg Arg150 155 160 165ttt gac caa gac acc gca gca ggt cgc gac gta gat ttc gac gct gtg 643Phe Asp Gln Asp Thr Ala Ala Gly Arg Asp Val Asp Phe Asp Ala Val

170 175 180ctg gca gat gtt gtt cgc cgc gat gaa cta gat tcc acc cgt gcc gcc 691Leu Ala Asp Val Val Arg Arg Asp Glu Leu Asp Ser Thr Arg Ala Ala

185 190 195tca ccg ctg aaa cca gca gat gat gca cac atc gtg gac acc tct gat 739Ser Pro Leu Lys Pro Ala Asp Asp Ala His Ile Val Asp Thr Ser Asp

200 205 210atg acc atg gat caa gta ctt gat cac ctc atc cac cta gtg gaa gcc 787Met Thr Met Asp Gln Val Leu Asp His Leu Ile His Leu Val Glu Ala

215220225 tcc gct gaa agg agc aac cag tgactgataa acacaccatg cct 831Ser Ala Glu Arg Ser Asn Gln 230235<210>996<211>236<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>996Val Thr Glu Ile Ser Asn Met Pro Ala Gly Gly Leu Ile Val Ala Ile 151015 Asp Gly Pro Ser Gly Thr Gly Lys Ser Thr Thr Ser Arg Ala Leu Ala

20 25 30Thr Arg Leu Ser Ala Lys Tyr Leu Asp Thr Gly Ala Met Tyr Arg Val

35 40 45Ala Thr Leu His Val Leu Asn Gln Gly Ile Asp Pro Ala Asp Ser Ala

50 55 60Ala Val Ile Ala Ala Thr Ala Val Leu Pro Leu Ser Ile Ser Asp Asp 65 70 75 80Pro Ala Ser Thr Glu Val Leu Leu Ala Gly Val Asp Val Gln Lys Asp

85 90 95Ile Arg Gly Pro Glu Val Thr Gln Asn Val Ser Ala Val Ser Ala Ile

100 105 110Pro Glu Val Arg Glu Asn Leu Val Ala Leu Gln Arg Ala Leu Ala Ala

115 120 125Lys Ala His Arg Cys Val Val Glu Gly Arg Asp Ile Gly Thr Ala Val

130 135 140Leu Val Asp Ala Pro Ile Lys Ala Phe Leu Thr Ala Ser Ala Glu Val145 150 155 160Arg Ala Gln Arg Arg Phe Asp Gln Asp Thr Ala Ala Gly Arg Asp Val

165 170 175Asp Phe Asp Ala Val Leu Ala Asp Val ValArg Arg Asp Glu Leu Asp

180 185 190Ser Thr Arg Ala Ala Ser Pro Leu Lys Pro Ala Asp Asp Ala His Ile

195 200 205Val Asp Thr Ser Asp Met Thr Met Asp Gln Val Leu Asp His Leu Ile

210215220 His Leu Val Glu Ala Ser Ala Glu Arg Ser Asn Gln 225230235<210>997<211>1785<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).)

Met Thr Ser Ser Arg

1 5aaa gtc cgt ccc acc aaa cac att ttc gtc acc ggt gga gtt gtt tcc 163Lys Val Arg Pro Thr Lys His Ile Phe Val Thr Gly Gly Val Val Ser

10 15 20tca ctc ggc aaa ggc ctg acc gca gca agc ctt ggt caa ttg ctg att 211Ser Leu Gly Lys Gly Leu Thr Ala Ala Ser Leu Gly Gln Leu Leu Ile

25 30 35gca cgg gga ctg tcg gtg acc atg cag aag ctg gat cca tac ctc aat 259Ala Arg Gly Leu Ser Val Thr Met Gln Lys Leu Asp Pro Tyr Leu Asn

40 45 50gtt gat ccg ggc acc atg aat cct ttt gaa cac ggt gaa gtc ttt gtc 307Val Asp Pro Gly Thr Met Asn Pro Phe Glu His Gly Glu Val Phe Val

55 60 65acc gaa gac ggg gca gaa aca gac ctg gat ttg ggc cac tac gag cgt 355Thr Glu Asp Gly Ala Glu Thr Asp Leu Asp Leu Gly His Tyr Glu Arg 70 75 80 85ttc ctc gat cgc aac ctg ggg ctc aac gcc aat gtc acc acc ggc aag 403Phe Leu Asp Arg Asn Leu Gly Leu Asn Ala Asn Val Thr Thr Gly Lys

90 95 100gtg tat tcc act gtg atc gcc aag gag cgc agg gga gag tac ctg ggt 451Val Tyr Ser Thr Val Ile Ala Lys Glu Arg Arg Gly Glu Tyr Leu Gly

105 110 115aaa act gtg cag gtc atc cca cac atc act gat gag atc aaa gct cgt 499Lys Thr Val Gln Val Ile Pro His Ile Thr Asp Glu Ile Lys Ala Arg

120 125 130att ttg agc atg ggc gaa cca gat gct cat ggt aac gcc cca gac gtg 547Ile Leu Ser Met Gly Glu Pro Asp Ala His Gly Asn Ala Pro Asp Val

135 140 145gtg atc tct gag gtc ggt ggc acc gtc ggt gac att gaa tcc cag cca 595Val Ile Ser Glu Val Gly Gly Thr Val Gly Asp Ile Glu Ser Gln Pro150 155 160 165ttc ctt gaa gca gct cgc cag gta cgc cat gaa att ggt cgt gaa aac 643Phe Leu Glu Ala Ala Arg Gln Val Arg His Glu Ile Gly Arg Glu Asn

170 175 180tgc ttc ttc atc cac tgt tct ttg gtg cca tac ttg gct acc tca ggt 691Cys Phe Phe Ile His Cys Ser Leu Val Pro Tyr Leu Ala Thr Ser Gly

185 190 195gag ctg aag acc aaa ccc acc cag cat tct gtc gca gag ctg cgc ggc 739Glu Leu Lys Thr Lys Pro Thr Gln His Ser Val Ala Glu Leu Arg Gly

200 205 210atc ggt att ttg ccg gat gct ctc gtg ctt cgt tgc gat cgg gag gtc 787Ile Gly Ile Leu Pro Asp Ala Leu Val Leu Arg Cys Asp Arg Glu Val

215 220 225cct caa ggt ctg aaa gat aag atc gcg atg atg tgc gat gtt gat tat 835Pro Gln Gly Leu Lys Asp Lys Ile Ala Met Met Cys Asp Val Asp Tyr230 235 240 245gaa ggc gtt gta tct tgc cct gat tcc agt tct atttac aac att cca 883Glu Gly Val Val Ser Cys Pro Asp Ser Ser Ser Ile Tyr Asn Ile Pro

250 255 260gat gtc ctc tac cgc gag cac ctg gac acc ttc att att cgt cgc ctg 931Asp Val Leu Tyr Arg Glu His Leu Asp Thr Phe Ile Ile Arg Arg Leu

265 270 275ggc ctt ccg ttc cgt gat gtt gac tgg agc acc tgg cac gat ctg ctg 979Gly Leu Pro Phe Arg Asp Val Asp Trp Ser Thr Trp His Asp Leu Leu

280 285 290gaa cgg gtg aac aac cca cgc cat gag ctc acc gtc ggc atc gtg ggc 1027Glu Arg Val Asn Asn Pro Arg His Glu Leu Thr Val Gly Ile Val Gly

295 300 305aag tac att gat ctt ccc gat gct tat ctc tca gtg gtg gaa gct gtt 1075Lys Tyr Ile Asp Leu Pro Asp Ala Tyr Leu Ser Val Val Glu Ala Val310 315 320 325cgc gct gca ggc tac gcc aat tgg acg cgc acc aat atc aag tgg att 1123Arg Ala Ala Gly Tyr Ala Asn Trp Thr Arg Thr Asn Ile Lys Trp Ile

330 335 340acc tca gat gat tgc gaa acc cca tct ggc gcc atg aaa gcg ctc agc 1171Thr Ser Asp Asp Cys Glu Thr Pro Ser Gly Ala Met Lys Ala Leu Ser

345 350 355ggt ttg gat gcc atc gtg gtt ccc gga ggt ttc ggt atc cga ggt atc 1219Gly Leu Asp Ala Ile Val Val Pro Gly Gly Phe Gly Ile Arg Gly Ile

360 365 370gaa ggc aaa atc ggt gcg att acg ttt gca cgt gag cac aag atc ccg 1267Glu Gly Lys Ile Gly Ala Ile Thr Phe Ala Arg Glu His Lys Ile Pro

375 380 385ctt ctt ggc cta tgc ctt ggc ctg cag tgc acc gtc atc gag gca gca 1315Leu Leu Gly Leu Cys Leu Gly Leu Gln Cys Thr Val Ile Glu Ala Ala390 395 400 405cgc cag gca gga ctg gag cag gca tca tcc act gag ttt gac cca gct 1363Arg Gln Ala Gly Leu Glu Gln Ala Ser Ser Thr Glu Phe Asp Pro Ala

410 415 420gca acg cag cca gtg atc gcc acc atg gaa gag cag aaa gct gct gtg 1411Ala Thr Gln Pro Val Ile Ala Thr Met Glu Glu Gln Lys Ala Ala Val

425 430 435tcg ggt gaa gct gat ctg ggt ggc acc atg cgt ctt ggc gca tat cct 1459Ser Gly Glu Ala Asp Leu Gly Gly Thr Met Arg Leu Gly Ala Tyr Pro

440 445 450gca acc ctg gag gaa ggc tcc tta gta gcg gaa ctg tat ggc aca acg 1507Ala Thr Leu Glu Glu Gly Ser Leu Val Ala Glu Leu Tyr Gly Thr Thr

455 460 465gaa gtc tcc gag cgc cac cgt cac cgc tat gag gtc aat aat gcc tac 1555Glu Val Ser Glu Arg His Arg His Arg Tyr Glu Val Asn Asn Ala Tyr470 475 480 485cgc gcc cag att gct gaa ggt tca gat ttg gtc ttc tcc gga acc tca 1603Arg Ala Gln Ile Ala Glu Gly Ser Asp Leu Val Phe Ser Gly Thr Ser

490 495 500cct gat gga cat ttg gtg gag ttc gtg gag tac ccc aaa gag gtg cat 1651Pro Asp Gly His Leu Val Glu Phe Val Glu Tyr Pro Lys Glu Val His

505 510 515cct tat ctg gtg gca acc cag gcg cac cct gag tac aaa tct cgt cca 1699Pro Tyr Leu Val Ala Thr Gln Ala His Pro Glu Tyr Lys Ser Arg Pro

520 525 530acc cat gct cat cca ctg ttt tac ggc ctg gtg aag acc gct ttg gag 1747Thr His Ala His Pro Leu Phe Tyr Gly Leu Val Lys Thr Ala Leu Glu

535540545 ctg cgt gtc cac ccttagatctaca atgtgatcat ggt 1785Leu Arg Val His Pro550<210>998<211>554<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>998Met Thr Ser Ser Arg Lys Val Arg Pro Thr Lys His Ile Phe Val Thr 151015 Gly Gly Val Val Ser Ser Leu Gly Lys Gly Leu Thr Ala Ala Ser Leu

20 25 30Gly Gln Leu Leu Ile Ala Arg Gly Leu Ser Val Thr Met Gln Lys Leu

35 40 45Asp Pro Tyr Leu Asn Val Asp Pro Gly Thr Met Asn Pro Phe Glu His

50 55 60Gly Glu Val Phe Val Thr Glu Asp Gly Ala Glu Thr Asp Leu Asp Leu 65 70 75 80Gly His Tyr Glu Arg Phe Leu Asp Arg Asn Leu Gly Leu Asn Ala Asn

85 90 95Val Thr Thr Gly Lys Val Tyr Ser Thr Val Ile Ala Lys Glu Arg Arg

100 105 110Gly Glu Tyr Leu Gly Lys Thr Val Gln Val Ile Pro His Ile Thr Asp

115 120 125Glu Ile Lys Ala Arg Ile Leu Ser Met Gly Glu Pro Asp Ala His Gly

130 135 140Asn Ala Pro Asp Val Val Ile Ser Glu Val Gly Gly Thr Val Gly Asp145 150 155 160Ile Glu Ser Gln Pro Phe Leu Glu Ala Ala Arg Gln Val Arg His Glu

165 170 175Ile Gly Arg Glu Asn Cys Phe Phe Ile His Cys Ser Leu Val Pro Tyr

180 185 190Leu Ala Thr Ser Gly Glu Leu Lys Thr Lys Pro Thr Gln His Ser Val

195 200 205Ala Glu Leu Arg GlyIle Gly Ile Leu Pro Asp Ala Leu Val Leu Arg

210 215 220Cys Asp Arg Glu Val Pro Gln Gly Leu Lys Asp Lys Ile Ala Met Met225 230 235 240Cys Asp Val Asp Tyr Glu Gly Val Val Ser Cys Pro Asp Ser Ser Ser

245 250 255Ile Tyr Asn Ile Pro Asp Val Leu Tyr Arg Glu His Leu Asp Thr Phe

260 265 270Ile Ile Arg Arg Leu Gly Leu Pro Phe Arg Asp Val Asp Trp Ser Thr

275 280 285Trp His Asp Leu Leu Glu Arg Val Asn Asn Pro Arg His Glu Leu Thr

290 295 300Val Gly Ile Val Gly Lys Tyr Ile Asp Leu Pro Asp Ala Tyr Leu Ser305 310 315 320Val Val Glu Ala Val Arg Ala Ala Gly Tyr Ala Asn Trp Thr Arg Thr

325 330 335Asn Ile Lys Trp Ile Thr Ser Asp Asp Cys Glu Thr Pro Ser Gly Ala

340 345 350Met Lys Ala Leu Ser Gly Leu Asp Ala Ile Val Val Pro Gly Gly Phe

355 360 365Gly Ile Arg Gly Ile Glu Gly Lys Ile Gly Ala Ile Thr Phe Ala Arg

370 375 380Glu His Lys Ile Pro Leu Leu Gly Leu Cys Leu Gly Leu Gln Cys Thr385 390 395 400Val Ile Glu Ala Ala Arg Gln Ala Gly Leu Glu Gln Ala Ser Ser Thr

405 410 415Glu Phe Asp Pro Ala Ala Thr Gln Pro Val Ile Ala Thr Met Glu Glu

420 425 430Gln Lys AlaAla Val Ser Gly Glu Ala Asp Leu Gly Gly Thr Met Arg

435 440 445Leu Gly Ala Tyr Pro Ala Thr Leu Glu Glu Gly Ser Leu Val Ala Glu

450 455 460Leu Tyr Gly Thr Thr Glu Val Ser Glu Arg His Arg His Arg Tyr Glu465 470 475 480Val Asn Asn Ala Tyr Arg Ala Gln Ile Ala Glu Gly Ser Asp Leu Val

485 490 495Phe Ser Gly Thr Ser Pro Asp Gly His Leu Val Glu Phe Val Glu Tyr

500 505 510Pro Lys Glu Val His Pro Tyr Leu Val Ala Thr Gln Ala His Pro Glu

515 520 525Tyr Lys Ser Arg Pro Thr His Ala His Pro Leu Phe Tyr Gly Leu Val

530535540 Lys Thr Ala Leu Glu Leu Arg Val His Pro 545550<210>999<211>3462<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (3439)<223>RXN02234<400>999acccagaggc cgctgccggc ccaaatgatg caagccccct gtttgaccag tttgttgagc 60tgatggatgc agacgctcag aagaaaggcg cataaataac atg cca aag cgt tca 115

Met Pro Lys Arg Ser

1 5gat att aac cac gtc ctc gtc atc ggt tcc ggc ccc atc gtc att ggc 163Asp Ile Asn His Val Leu Val Ile Gly Ser Gly Pro Ile Val Ile Gly

10 15 20cag gca tgt gaa ttc gac tac tcc ggc acc cag gct tgc cgc gtg ctg 211Gln Ala Cys Glu Phe Asp Tyr Ser Gly Thr Gln Ala Cys Arg Val Leu

25 30 35aag gaa gag gga ctg cgcgtc acc ctc atc aac tcc aac cca gca acg 259Lys Glu Glu Gly Leu Arg Val Thr Leu Ile Asn Ser Asn Pro Ala Thr

40 45 50atc atg acc gac cca gaa atg gct gac cac acc tac gtg gag cca atc 307Ile Met Thr Asp Pro Glu Met Ala Asp His Thr Tyr Val Glu Pro Ile

55 60 65gag ccg gaa tac atc gac aag att ttc gct aag gaa atc gag cag ggc 355Glu Pro Glu Tyr Ile Asp Lys Ile Phe Ala Lys Glu Ile Glu Gln Gly 70 75 80 85cac cca atc gac gcc gtc ctg gca acc ctt ggt ggc cag act gca ctt 403His Pro Ile Asp Ala Val Leu Ala Thr Leu Gly Gly Gln Thr Ala Leu

90 95 100aac gca gct atc cag ctg gat cgc ctc ggc atc ctg gaa aag tac ggc 451Asn Ala Ala Ile Gln Leu Asp Arg Leu Gly Ile Leu Glu Lys Tyr Gly

105 110 115gtt gaa ctc atc ggt gca gac atc gat gcc att gag cgc ggc gaa gat 499Val Glu Leu Ile Gly Ala Asp Ile Asp Ala Ile Glu Arg Gly Glu Asp

120 125 130cgc cag aag ttc aag gat att gtc acc acc atc ggt ggc gaa tcc gcg 547Arg Gln Lys Phe Lys Asp Ile Val Thr Thr Ile Gly Gly Glu Ser Ala

135 140 145cgt tcc cgc gtc tgc cac aac atg gaa gaa gtc cac gag act gtc gca 595Arg Ser Arg Val Cys His Asn Met Glu Glu Val His Glu Thr Val Ala150 155 160 165gaa ctc ggc ctt cca gta gtc gtg cgt cca tcc ttc act atg ggt ggc 643Glu Leu Gly Leu Pro Val Val Val Arg Pro Ser Phe Thr Met Gly Gly

170 175 180ctg ggc tcc ggt ctt gca tac aac acc gaa gac ctt gag cgc atc gct 691Leu Gly Ser Gly Leu Ala Tyr Asn Thr Glu Asp Leu Glu ArgIle Ala

185 190 195ggt ggc gga ctt gct gca tct cct gaa gca aac gtc ttg atc gaa gaa 739Gly Gly Gly Leu Ala Ala Ser Pro Glu Ala Asn Val Leu Ile Glu Glu

200 205 210tcc atc ctt ggt tgg aag gaa ttc gag ctc gag ctc atg cgc gat acc 787Ser Ile Leu Gly Trp Lys Glu Phe Glu Leu Glu Leu Met Arg Asp Thr

215 220 225gca gac aac gtt gtg gtt atc tgc tcc att gaa aac gtc gac gca ctg 835Ala Asp Asn Val Val Val Ile Cys Ser Ile Glu Asn Val Asp Ala Leu230 235 240 245ggc gtg cac acc ggc gac tct gtc acc gtg gca cct gcc ctg acc ctg 883Gly Val His Thr Gly Asp Ser Val Thr Val Ala Pro Ala Leu Thr Leu

250 255 260act gac cgt gaa ttc cag aag atg cgc gat cag ggt atc gcc atc atc 931Thr Asp Arg Glu Phe Gln Lys Met Arg Asp Gln Gly Ile Ala Ile Ile

265 270 275cgc gag gtc ggc gtg gac acc ggt gga tgt aac atc cag ttc gcc atc 979Arg Glu Val Gly Val Asp Thr Gly Gly Cys Asn Ile Gln Phe Ala Ile

280 285 290aac cca gtt gat ggc cgc atc atc acc att gag atg aac cca cgt gtg 1027Asn Pro Val Asp Gly Arg Ile Ile Thr Ile Glu Met Asn Pro Arg Val

295 300 305tct cgt tcc tcc gct ctg gca tcc aag gca acg ggc ttc cca att gcc 1075Ser Arg Ser Ser Ala Leu Ala Ser Lys Ala Thr Gly Phe Pro Ile Ala310 315 320 325aag atg gct gcc aag ctg gct atc gga tac acc ctg gat gag atc acc 1123Lys Met Ala Ala Lys Leu Ala Ile Gly Tyr Thr Leu Asp Glu Ile Thr

330 335 340aacgac atc act ggt gaa acc cca gct gcg ttt gag ccc acc atc gac 1171Asn Asp Ile Thr Gly Glu Thr Pro Ala Ala Phe Glu Pro Thr Ile Asp

345 350 355tac gtc gtg gtc aag gcc cca cgc ttt gct ttc gag aag ttt gtc ggc 1219Tyr Val Val Val Lys Ala Pro Arg Phe Ala Phe Glu Lys Phe Val Gly

360 365 370gct gat gac act ttg acc acc acc atg aag tcc gtc ggt gag gtc atg 1267Ala Asp Asp Thr Leu Thr Thr Thr Met Lys Ser Val Gly Glu Val Met

375 380 385tcc ctg ggc cgc aac tac att gca gca ctg aac aag gca ctg cgt tcc 1315Ser Leu Gly Arg Asn Tyr Ile Ala Ala Leu Asn Lys Ala Leu Arg Ser390 395 400 405ctg gaa acc aag cag cag ggt ttc tgg acc aag cct gat gag ttc ttc 1363Leu Glu Thr Lys Gln Gln Gly Phe Trp Thr Lys Pro Asp Glu Phe Phe

410 415 420gca ggg gag cgc gct acc gat aag gca gct gtt ctg gaa gat ctc aag 1411Ala Gly Glu Arg Ala Thr Asp Lys Ala Ala Val Leu Glu Asp Leu Lys

425 430 435cgc cca acc gaa ggc cgc ctc tac gac gtt gag ctg gca atg cgc ctt 1459Arg Pro Thr Glu Gly Arg Leu Tyr Asp Val Glu Leu Ala Met Arg Leu

440 445 450ggc gca agc gtg gaa gaa ctc tac gaa gca tct tct att gat cct tgg 1507Gly Ala Ser Val Glu Glu Leu Tyr Glu Ala Ser Ser Ile Asp Pro Trp

455 460 465ttc ctc gcc gag ctt gaa gct ctc gtg cag ttc cgc cag aag ctc gtt 1555Phe Leu Ala Glu Leu Glu Ala Leu Val Gln Phe Arg Gln Lys Leu Val470 475 480 485gac gca cca ttc cta aac gaa gat ctc ctg cgc gaa gca aag ttc atg 1603Asp Ala Pro Phe Leu Asn Glu Asp Leu Leu Arg Glu Ala Lys Phe Met

490 495 500ggt ctg tcc gac ctg cag atc gca gcc ctt cgc cca gag ttc gct ggc 1651Gly Leu Ser Asp Leu Gln Ile Ala Ala Leu Arg Pro Glu Phe Ala Gly

505 510 515gaa gac ggc gta cgc acc ttg cgt ctg tcc cta ggc atc cgc cca gta 1699Glu Asp Gly Val Arg Thr Leu Arg Leu Ser Leu Gly Ile Arg Pro Val

520 525 530ttc aag act gtg gat acc tgt gca gca gag ttt gaa gct aag act ccg 1747Phe Lys Thr Val Asp Thr Cys Ala Ala Glu Phe Glu Ala Lys Thr Pro

535 540 545tac cac tac tcc gca tac gag ctg gat cca gca gct gag tct gag gtc 1795Tyr His Tyr Ser Ala Tyr Glu Leu Asp Pro Ala Ala Glu Ser Glu Val550 555 560 565gca cca cag act gag cgt gaa aag gtc ctg atc ttg ggc tcc ggt cca 1843Ala Pro Gln Thr Glu Arg Glu Lys Val Leu Ile Leu Gly Ser Gly Pro

570 575 580aac cgc atc ggc cag ggc atc gag ttc gac tac tcc tgt gtt cac gca 1891Asn Arg Ile Gly Gln Gly Ile Glu Phe Asp Tyr Ser Cys Val His Ala

585 590 595gct ctt gag ctc tcc cgc gtc ggc tac gaa act gtc atg gtc aac tgc 1939Ala Leu Glu Leu Ser Arg Val Gly Tyr Glu Thr Val Met Val Asn Cys

600 605 610aac cca gag acc gtg tcc acc gac tac gac acc gct gac cgc ctg tac 1987Asn Pro Glu Thr Val Ser Thr Asp Tyr Asp Thr Ala Asp Arg Leu Tyr

615 620 625ttc gag cca ctg acc ttc gaa gac gtc atg gag gtc tac cac gct gag 2035Phe Glu Pro Leu Thr Phe Glu Asp Val Met Glu Val Tyr His Ala Glu630 635640 645gcg cag tcc ggc acc gtc gca ggt gtt atc gtc cag ctt ggt ggc cag 2083Ala Gln Ser Gly Thr Val Ala Gly Val Ile Val Gln Leu Gly Gly Gln

650 655 660act cct ctg ggc ttg gca gat cgt ttg aag aag gct ggc gtc cct gtc 2131Thr Pro Leu Gly Leu Ala Asp Arg Leu Lys Lys Ala Gly Val Pro Val

665 670 675att ggt acc tcc cca gag gca atc gac atg gct gag gac cgt ggc gag 2179Ile Gly Thr Ser Pro Glu Ala Ile Asp Met Ala Glu Asp Arg Gly Glu

680 685 690ttc ggt gca ctg ctg aac cgc gag cag ctt cct gct cca gca ttc ggc 2227Phe Gly Ala Leu Leu Asn Arg Glu Gln Leu Pro Ala Pro Ala Phe Gly

695 700 705acc gca acc tct ttc gaa gag gct cgc aca gta gcc gat gag atc agc 2275Thr Ala Thr Ser Phe Glu Glu Ala Arg Thr Val Ala Asp Glu Ile Ser710 715 720 725tac cca gtg ctg gtt cgc cct tcc tac gtc ttg ggt ggc cgt ggc atg 2323Tyr Pro Val Leu Val Arg Pro Ser Tyr Val Leu Gly Gly Arg Gly Met

730 735 740gag att gtc tac gat gag gct tcc ctc gag gat tac atc aac cgc gca 2371Glu Ile Val Tyr Asp Glu Ala Ser Leu Glu Asp Tyr Ile Asn Arg Ala

745 750 755act gag ttg tct tct gac cac cca gtg ctg gtt gac cgc ttc cta gac 2419Thr Glu Leu Ser Ser Asp His Pro Val Leu Val Asp Arg Phe Leu Asp

760 765 770aac gct att gag atc gac gtc gac gca ctg tgc gac ggc gac gag gtc 2467Asn Ala Ile Glu Ile Asp Val Asp Ala Leu Cys Asp Gly Asp Glu Val

775 780 785tac ctg gca ggc gtc atg gag cac atc gag gaa gcc ggc att cac tcc 2515Tyr Leu Ala Gly Val Met Glu His Ile Glu Glu Ala Gly Ile His Ser790 795 800 805ggt gac tcc gca tgt gca ctt cct cca atg act ttg ggc gca cag gac 2563Gly Asp Ser Ala Cys Ala Leu Pro Pro Met Thr Leu Gly Ala Gln Asp

810 815 820atc gag aag gtc cgc gaa gca acc aag aag ctg gct ctg ggc atc ggt 2611Ile Glu Lys Val Arg Glu Ala Thr Lys Lys Leu Ala Leu Gly Ile Gly

825 830 835gta cag ggc ctg atg aac gtc cag tac gca ctc aag gac gac atc ctc 2659Val Gln Gly Leu Met Asn Val Gln Tyr Ala Leu Lys Asp Asp Ile Leu

840 845 850tac gtc atc gag gca aac cca cgt gca tcc cgc acc gtg ccg ttc gtc 2707Tyr Val Ile Glu Ala Asn Pro Arg Ala Ser Arg Thr Val Pro Phe Val

855 860 865tcc aag gca acg ggc gtc aac ctg gcc aag gca gca tcc cgt atc gca 2755Ser Lys Ala Thr Gly Val Asn Leu Ala Lys Ala Ala Ser Arg Ile Ala870 875 880 885gtg ggc gcc acc atc aag gat ctc caa gat gag ggc atg att cct acc 2803Val Gly Ala Thr Ile Lys Asp Leu Gln Asp Glu Gly Met Ile Pro Thr

890 895 900gag tac gac ggc ggc tcc ttg cca ctg gac gct cca atc gct gtg aag 2851Glu Tyr Asp Gly Gly Ser Leu Pro Leu Asp Ala Pro Ile Ala Val Lys

905 910 915gaa gca gtg ttg ccg ttc aac cgc ttc cgt cgc cca gat gga aag acc 2899Glu Ala Val Leu Pro Phe Asn Arg Phe Arg Arg Pro Asp Gly Lys Thr

920 925 930ctg gac acc ctg ctt tcc cca gag atg aag tcc act ggc gag gtc atg 2947Leu Asp Thr Leu Leu Ser Pro Glu Met Lys Ser Thr Gly Glu Val Met

935 940 945ggc ttg gcc aac aac ttc ggc gct gca tat gca aag gct gaa gct ggc 2995Gly Leu Ala Asn Asn Phe Gly Ala Ala Tyr Ala Lys Ala Glu Ala Gly950 955 960 965gcg ttt ggt gca ttg cca acc gaa ggc acc gtc ttc gtg acc gtg gct 3043Ala Phe Gly Ala Leu Pro Thr Glu Gly Thr Val Phe Val Thr Val Ala

970 975 980aac cgc gac aag cgc acc ctg atc ctg cca atc cag cgc ctg gcg ttg 3091Asn Arg Asp Lys Arg Thr Leu Ile Leu Pro Ile Gln Arg Leu Ala Leu

985 990 995atg ggc tac aag atc ctc gcc acc gaa ggc acc gca ggc atg ctg cgc 3139Met Gly Tyr Lys Ile Leu Ala Thr Glu Gly Thr Ala Gly Met Leu Arg

1000 1005 1010cgc aac ggc att gag tgt gaa gtt gtg ctc aag gct tcc gac atc cgc 3187Arg Asn Gly Ile Glu Cys Glu Val Val Leu Lys Ala Ser Asp Ile Arg

1015 1020 1025gaa ggt gta gag ggc aag tcc atc gtg gat cgt atc cgc gaa ggc gaa 3235Glu Gly Val Glu Gly Lys Ser Ile Val Asp Arg Ile Arg Glu Gly Glu1030 1035 1040 1045gtt gac ctc atc ctc aac acc cca gct ggt tct gct ggc gct cgc cac 3283Val Asp Leu Ile Leu Asn Thr Pro Ala Gly Ser Ala Gly Ala Arg His

1050 1055 1060gat ggc tac gat atc cgc gca gca gca gtg acc gtg ggt gtt ccg ctg 3331Asp Gly Tyr Asp Ile Arg Ala Ala Ala Val Thr Val Gly Val Pro Leu

1065 1070 1075atc acc act gtt cag ggt gtc acc gca gct gtc cag ggc ata gag gcc 3379Ile Thr Thr Val Gln Gly Val Thr Ala Ala Val Gln Gly Ile Glu Ala

10801085 1090ctg cgt gag ggc gtt gtc agc gtc cgc gcg ctg cag gaa ctc gac cac 3427Leu Arg Glu Gly Val Val Ser Val Arg Ala Leu Gln Glu Leu Asp His

109511001105 gca gtc aag gct taagccctat gacattcggc gag 3462Ala Val Lys Ala1110<210>1000<211>1113<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1000Met Pro Lys Arg Ser Asp Ile Asn His Val Leu Val Ile Gly Ser Gly 151015 Pro Ile Val Ile Gly Gln Ala Cys Glu Phe Asp Tyr Ser Gly Thr Gln

20 25 30Ala Cys Arg Val Leu Lys Glu Glu Gly Leu Arg Val Thr Leu Ile Asn

35 40 45Ser Asn Pro Ala Thr Ile Met Thr Asp Pro Glu Met Ala Asp His Thr

50 55 60Tyr Val Glu Pro Ile Glu Pro Glu Tyr Ile Asp Lys Ile Phe Ala Lys 65 70 75 80Glu Ile Glu Gln Gly His Pro Ile Asp Ala Val Leu Ala Thr Leu Gly

85 90 95 Gly Gln Thr Ala Leu Asn Ala Ala Ile Gln Leu Asp Arg Leu Gly Ile

100 105 110Leu Glu Lys Tyr Gly Val Glu Leu Ile Gly Ala Asp Ile Asp Ala Ile

115 120 125Glu Arg Gly Glu Asp Arg Gln Lys Phe Lys Asp Ile Val Thr Thr Ile

130 135 140Gly Gly Glu Ser Ala Arg Ser Arg Val Cys His Asn Met Glu Glu Val145 150 155 160His Glu Thr Val Ala Glu Leu Gly Leu Pro Val Val Val Arg Pro Ser

165 170 175 Phe Thr Met Gly Gly Leu Gly Ser Gly Leu Ala Tyr Asn Thr Glu Asp

180 185 190Leu Glu Arg Ile Ala Gly Gly Gly Leu Ala Ala Ser Pro Glu Ala Asn

195 200 205Val Leu Ile Glu Glu Ser Ile Leu Gly Trp Lys Glu Phe Glu Leu Glu

210 215 220Leu Met Arg Asp Thr Ala Asp Asn Val Val Val Ile Cys Ser Ile Glu225 230 235 240Asn Val Asp Ala Leu Gly Val His Thr Gly Asp Ser Val Thr Val Ala

245 250 255Pro Ala Leu Thr Leu Thr Asp Arg Glu Phe Gln Lys Met Arg Asp Gln

260 265 270Gly Ile Ala Ile Ile Arg Glu Val Gly Val Asp Thr Gly Gly Cys Asn

275 280 285Ile Gln Phe Ala Ile Asn Pro Val Asp Gly Arg Ile Ile Thr Ile Glu

290 295 300Met Asn Pro Arg Val Ser Arg Ser Ser Ala Leu Ala Ser Lys Ala Thr305 310 315 320Gly Phe Pro Ile Ala Lys Met Ala Ala Lys Leu Ala Ile Gly Tyr Thr

325 330 335Leu Asp Glu Ile Thr Asn Asp Ile Thr Gly Glu Thr Pro Ala Ala Phe

340 345 350Glu Pro Thr Ile Asp Tyr Val Val Val Lys Ala Pro Arg Phe Ala Phe

355 360 365Glu Lys Phe Val Gly Ala Asp Asp Thr Leu Thr Thr Thr Met Lys Ser

370 375 380Val Gly Glu Val Met Ser Leu Gly Arg Asn Tyr Ile Ala Ala Leu Asn385 390 395 400Lys Ala Leu Arg Ser Leu Glu Thr Lys Gln Gln Gly Phe Trp Thr Lys

405 410 415Pro Asp Glu Phe Phe Ala Gly Glu Arg Ala Thr Asp Lys Ala Ala Val

420 425 430Leu Glu Asp Leu Lys Arg Pro Thr Glu Gly Arg Leu Tyr Asp Val Glu

435 440 445Leu Ala Met Arg Leu Gly Ala Ser Val Glu Glu Leu Tyr Glu Ala Ser

450 455 460Ser Ile Asp Pro Trp Phe Leu Ala Glu Leu Glu Ala Leu Val Gln Phe465 470 475 480Arg Gln Lys Leu Val Asp Ala Pro Phe Leu Asn Glu Asp Leu Leu Arg

485 490 495Glu Ala Lys Phe Met Gly Leu Ser Asp Leu Gln Ile Ala Ala Leu Arg

500 505 510Pro Glu Phe Ala Gly Glu Asp Gly Val Arg Thr Leu Arg Leu Ser Leu

515 520 525Gly Ile Arg Pro Val Phe Lys Thr Val Asp Thr Cys Ala Ala Glu Phe

530 535 540Glu Ala Lys Thr Pro Tyr His Tyr Ser Ala Tyr Glu Leu Asp Pro Ala545 550 555 560Ala Glu Ser Glu Val Ala Pro Gln Thr Glu Arg Glu Lys Val Leu Ile

565 570 575Leu Gly Ser Gly Pro Asn Arg Ile Gly Gln Gly Ile Glu Phe Asp Tyr

580 585 590Ser Cys Val His Ala Ala Leu Glu Leu Ser Arg Val Gly Tyr Glu Thr

595 600 605Val Met Val Asn Cys Asn Pro Glu Thr Val Ser Thr Asp Tyr Asp Thr

610 615 620Ala Asp Arg Leu Tyr Phe Glu Pro Leu Thr Phe Glu Asp ValMet Glu625 630 635 640Val Tyr His Ala Glu Ala Gln Ser Gly Thr Val Ala Gly Val Ile Val

645 650 655Gln Leu Gly Gly Gln Thr Pro Leu Gly Leu Ala Asp Arg Leu Lys Lys

660 665 670Ala Gly Val Pro Val Ile Gly Thr Ser Pro Glu Ala Ile Asp Met Ala

675 680 685Glu Asp Arg Gly Glu Phe Gly Ala Leu Leu Asn Arg Glu Gln Leu Pro

690 695 700Ala Pro Ala Phe Gly Thr Ala Thr Ser Phe Glu Glu Ala Arg Thr Val705 710 715 720Ala Asp Glu Ile Ser Tyr Pro Val Leu Val Arg Pro Ser Tyr Val Leu

725 730 735Gly Gly Arg Gly Met Glu Ile Val Tyr Asp Glu Ala Ser Leu Glu Asp

740 745 750Tyr Ile Asn Arg Ala Thr Glu Leu Ser Ser Asp His Pro Val Leu Val

755 760 765Asp Arg Phe Leu Asp Asn Ala Ile Glu Ile Asp Val Asp Ala Leu Cys

770 775 780Asp Gly Asp Glu Val Tyr Leu Ala Gly Val Met Glu His Ile Glu Glu785 790 795 800Ala Gly Ile His Ser Gly Asp Ser Ala Cys Ala Leu Pro Pro Met Thr

805 810 815Leu Gly Ala Gln Asp Ile Glu Lys Val Arg Glu Ala Thr Lys Lys Leu

820 825 830Ala Leu Gly Ile Gly Val Gln Gly Leu Met Asn Val Gln Tyr Ala Leu

835 840 845Lys Asp Asp Ile Leu Tyr Val Ile Glu Ala AsnPro Arg Ala Ser Arg

850 855 860Thr Val Pro Phe Val Ser Lys Ala Thr Gly Val Asn Leu Ala Lys Ala865 870 875 880Ala Ser Arg Ile Ala Val Gly Ala Thr Ile Lys Asp Leu Gln Asp Glu

885 890 895Gly Met Ile Pro Thr Glu Tyr Asp Gly Gly Ser Leu Pro Leu Asp Ala

900 905 910Pro Ile Ala Val Lys Glu Ala Val Leu Pro Phe Asn Arg Phe Arg Arg

915 920 925Pro Asp Gly Lys Thr Leu Asp Thr Leu Leu Ser Pro Glu Met Lys Ser

930 935 940Thr Gly Glu Val Met Gly Leu Ala Asn Asn Phe Gly Ala Ala Tyr Ala945 950 955 960Lys Ala Glu Ala Gly Ala Phe Gly Ala Leu Pro Thr Glu Gly Thr Val

965 970 975Phe Val Thr Val Ala Asn Arg Asp Lys Arg Thr Leu Ile Leu Pro Ile

980 985 990Gln Arg Leu Ala Leu Met Gly Tyr Lys Ile Leu Ala Thr Glu Gly Thr

995 1000 1005Ala Gly Met Leu Arg Arg Asn Gly Ile Glu Cys Glu Val Val Leu Lys

1010 1015 1020Ala Ser Asp Ile Arg Glu Gly Val Glu Gly Lys Ser Ile Val Asp Arg1025 1030 1035 1040Ile Arg Glu Gly Glu Val Asp Leu Ile Leu Asn Thr Pro Ala Gly Ser

1045 1050 1055Ala Gly Ala Arg His Asp Gly Tyr Asp Ile Arg Ala Ala Ala Val Thr

1060 1065 1070Val Gly Val Pro Leu Ile Thr Thr Val Gln Gly Val Thr Ala Ala Val

1075 1080 1085Gln Gly Ile Glu Ala Leu Arg Glu Gly Val Val Ser Val Arg Ala Leu

109010951100 Gln Glu Leu Asp His Ala Val Lys Ala 11051110<210>1001<211>3221<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (3198)<223>FRXA02234<400>1001ggc tcc aac cca gca acg atc atg acc gac cca gaa atg gct gac cac 48Gly Ser Asn Pro Ala Thr Ile Met Thr Asp Pro Glu Met Ala Asp His 151015 acc tac gtg gag cca atc gag ccg gaa tac atc gac aag att ttc gct 96Thr Tyr Val Glu Pro Ile Glu Pro Glu Tyr Ile Asp Lys Ile Phe Ala

20 25 30aag gaa atc gag cag ggc cac cca atc gac gcc gtc ctg gca acc ctt 144Lys Glu Ile Glu Gln Gly His Pro Ile Asp Ala Val Leu Ala Thr Leu

35 40 45ggt ggc cag act gca ctt aac gca gct atc cag ctg gat cgc ctc ggc 192Gly Gly Gln Thr Ala Leu Asn Ala Ala Ile Gln Leu Asp Arg Leu Gly

50 55 60atc ctg gaa aag tac ggc gtt gaa ctc atc ggt gca gac atc gat gcc 240Ile Leu Glu Lys Tyr Gly Val Glu Leu Ile Gly Ala Asp Ile Asp Ala 65 70 75 80att gag cgc ggc gaa gat cgc cag aag ttc aag gat att gtc acc acc 288Ile Glu Arg Gly Glu Asp Arg Gln Lys Phe Lys Asp Ile Val Thr Thr

85 90 95atc ggt ggc gaa tcc gcg cgt tcc cgc gtc tgc cac aac atg gaa gaa 336Ile Gly Gly Glu Ser Ala Arg Ser Arg Val Cys His Asn Met Glu Glu

100 105 110gtc cac gag act gtc gca gaa ctc ggc ctt cca gta gtc gtg cgt cca 384Val His Glu Thr Val Ala Glu Leu Gly Leu Pro Val Val Val Arg Pro

115 120 125tcc ttc act atg ggt ggc ctg ggc tcc ggt ctt gca tac aac acc gaa 432Ser Phe Thr Met Gly Gly Leu Gly Ser Gly Leu Ala Tyr Asn Thr Glu

130 135 140gac ctt gag cgc atc gct ggt ggc gga ctt gct gca tct cct gaa gca 480Asp Leu Glu Arg Ile Ala Gly Gly Gly Leu Ala Ala Ser Pro Glu Ala145 150 155 160aac gtc ttg atc gaa gaa tcc atc ctt ggt tgg aag gaa ttc gag ctc 528Asn Val Leu Ile Glu Glu Ser Ile Leu Gly Trp Lys Glu Phe Glu Leu

165 170 175gag ctc atg cgc gat acc gca gac aac gtt gtg gtt atc tgc tcc att 576Glu Leu Met Arg Asp Thr Ala Asp Asn Val Val Val Ile Cys Ser Ile

180 185 190gaa aac gtc gac gca ctg ggc gtg cac acc ggc gac tct gtc acc gtg 624Glu Asn Val Asp Ala Leu Gly Val His Thr Gly Asp Ser Val Thr Val

195 200 205gca cct gcc ctg acc ctg act gac cgt gaa ttc cag aag atg cgc gat 672Ala Pro Ala Leu Thr Leu Thr Asp Arg Glu Phe Gln Lys Met Arg Asp

210 215 220cag ggt atc gcc atc atc cgc gag gtc ggc gtg gac acc ggt gga tgt 720Gln Gly Ile Ala Ile Ile Arg Glu Val Gly Val Asp Thr Gly Gly Cys225 230 235 240aac atc cag ttc gcc atc aac cca gtt gat ggc cgc atc atc acc att 768Asn Ile Gln Phe Ala Ile Asn Pro Val Asp Gly Arg Ile Ile Thr Ile

245 250 255gag atg aac cca cgt gtg tct cgt tcc tcc gct ctg gca tcc aag gca 816Glu Met Asn Pro Arg Val Ser Arg Ser Ser Ala Leu Ala Ser Lys Ala

260 265 270acg ggc ttc cca att gcc aag atg gct gcc aag ctg gct atc gga tac 864Thr Gly Phe Pro Ile Ala Lys Met Ala Ala Lys Leu Ala Ile Gly Tyr

275 280 285acc ctg gat gag atc acc aac gac atc act ggt gaa acc cca gct gcg 912Thr Leu Asp Glu Ile Thr Asn Asp Ile Thr Gly Glu Thr Pro Ala Ala

290 295 300ttt gag ccc acc atc gac tac gtc gtg gtc aag gcc cca cgc ttt gct 960Phe Glu Pro Thr Ile Asp Tyr Val Val Val Lys Ala Pro Arg Phe Ala305 310 315 320ttc gag aag ttt gtc ggc gct gat gac act ttg acc acc acc atg aag 1008Phe Glu Lys Phe Val Gly Ala Asp Asp Thr Leu Thr Thr Thr Met Lys

325 330 335tcc gtc ggt gag gtc atg tcc ctg ggc cgc aac tac att gca gca ctg 1056Ser Val Gly Glu Val Met Ser Leu Gly Arg Asn Tyr Ile Ala Ala Leu

340 345 350aac aag gca ctg cgt tcc ctg gaa acc aag cag cag ggt ttc tgg acc 1104Asn Lys Ala Leu Arg Ser Leu Glu Thr Lys Gln Gln Gly Phe Trp Thr

355 360 365aag cct gat gag ttc ttc gca ggg gag cgc gct acc gat aag gca gct 1152Lys Pro Asp Glu Phe Phe Ala Gly Glu Arg Ala Thr Asp Lys Ala Ala

370 375 380gtt ctg gaa gat ctc aag cgc cca acc gaa ggc cgc ctc tac gac gtt 1200Val Leu Glu Asp Leu Lys Arg Pro Thr Glu Gly Arg Leu Tyr Asp Val385 390 395 400gag ctg gca atg cgc ctt ggc gca agc gtg gaa gaa ctc tac gaa gca 1248Glu Leu Ala Met Arg Leu Gly Ala Ser Val Glu Glu Leu Tyr Glu Ala

405 410 415tct tct att gat cct tgg ttc ctc gcc gag ctt gaa gct ctc gtg cag 1296Ser Ser Ile Asp Pro Trp Phe Leu Ala Glu Leu Glu Ala Leu Val Gln

420 425 430ttc cgc cag aag ctc gtt gac gca cca ttc cta aac gaa gat ctc ctg 1344Phe Arg Gln Lys Leu Val Asp Ala Pro Phe Leu Asn Glu Asp Leu Leu

435 440 445cgc gaa gca aag ttc atg ggt ctg tcc gac ctg cag atc gca gcc ctt 1392Arg Glu Ala Lys Phe Met Gly Leu Ser Asp Leu Gln Ile Ala Ala Leu

450 455 460cgc cca gag ttc gct ggc gaa gac ggc gta cgc acc ttg cgt ctg tcc 1440Arg Pro Glu Phe Ala Gly Glu Asp Gly Val Arg Thr Leu Arg Leu Ser465 470 475 480cta ggc atc cgc cca gta ttc aag act gtg gat acc tgt gca gca gag 1488Leu Gly Ile Arg Pro Val Phe Lys Thr Val Asp Thr Cys Ala Ala Glu

485 490 495ttt gaa gct aag act ccg tac cac tac tcc gca tac gag ctg gat cca 1536Phe Glu Ala Lys Thr Pro Tyr His Tyr Ser Ala Tyr Glu Leu Asp Pro

500 505 510gca gct gag tct gag gtc gca cca cag act gag cgt gaa aag gtc ctg 1584Ala Ala Glu Ser Glu Val Ala Pro Gln Thr Glu Arg Glu Lys Val Leu

515 520 525atc ttg ggc tcc ggt cca aac cgc atc ggc cag ggc atc gag ttc gac 1632Ile Leu Gly Ser Gly Pro Asn Arg Ile Gly Gln Gly Ile Glu Phe Asp

530 535 540tac tcc tgt gtt cac gca gct ctt gag ctc tcc cgc gtc ggc tac gaa 1680Tyr Ser Cys Val His Ala Ala Leu Glu Leu Ser Arg Val Gly Tyr Glu545 550 555 560act gtc atg gtc aac tgc aac cca gag acc gtg tcc acc gac tac gac 1728Thr Val Met Val Asn Cys Asn Pro Glu Thr Val Ser Thr Asp Tyr Asp

565 570 575acc gct gac cgc ctg tac ttc gag cca ctg acc ttc gaa gac gtc atg 1776Thr Ala Asp Arg Leu Tyr Phe Glu Pro Leu Thr Phe Glu Asp Val Met

580 585 590gag gtc tac cac gct gag gcg cag tcc ggc acc gtc gca ggt gtt atc 1824Glu Val Tyr His Ala Glu Ala Gln Ser Gly Thr Val Ala Gly Val Ile

595 600 605gtc cag ctt ggt ggc cag act cct ctg ggc ttg gca gat cgt ttg aag 1872Val Gln Leu Gly Gly Gln Thr Pro Leu Gly Leu Ala Asp Arg Leu Lys

610 615 620aag gct ggc gtc cct gtc att ggt acc tcc cca gag gca atc gac atg 1920Lys Ala Gly Val Pro Val Ile Gly Thr Ser Pro Glu Ala Ile Asp Met625 630 635 640gct gag gac cgt ggc gag ttc ggt gca ctg ctg aac cgc gag cag ctt 1968Ala Glu Asp Arg Gly Glu Phe Gly Ala Leu Leu Asn Arg Glu Gln Leu

645 650 655cct gct cca gca ttc ggc acc gca acc tct ttc gaa gag gct cgc aca 2016Pro Ala Pro Ala Phe Gly Thr Ala Thr Ser Phe Glu Glu Ala Arg Thr

660 665 670gta gcc gat gag atc agc tac cca gtg ctg gtt cgc cct tcc tac gtc 2064Val Ala Asp Glu Ile Ser Tyr Pro Val Leu Val Arg Pro Ser Tyr Val

675 680 685ttg ggt ggc cgt ggc atg gag att gtc tac gat gag gct tcc ctc gag 2112Leu Gly Gly Arg Gly Met Glu Ile Val Tyr Asp Glu Ala Ser Leu Glu

690 695 700gat tac atc aac cgc gca act gag ttg tct tct gac cac cca gtg ctg 2160Asp Tyr Ile Asn Arg Ala Thr Glu Leu Ser Ser Asp His Pro Val Leu705 710 715720gtt gac cgc ttc cta gac aac gct att gag atc gac gtc gac gca ctg 2208Val Asp Arg Phe Leu Asp Asn Ala Ile Glu Ile Asp Val Asp Ala Leu

725 730 735tgc gac ggc gac gag gtc tac ctg gca ggc gtc atg gag cac atc gag 2256Cys Asp Gly Asp Glu Val Tyr Leu Ala Gly Val Met Glu His Ile Glu

740 745 750gaa gcc ggc att cac tcc ggt gac tcc gca tgt gca ctt cct cca atg 2304Glu Ala Gly Ile His Ser Gly Asp Ser Ala Cys Ala Leu Pro Pro Met

755 760 765act ttg ggc gca cag gac atc gag aag gtc cgc gaa gca acc aag aag 2352Thr Leu Gly Ala Gln Asp Ile Glu Lys Val Arg Glu Ala Thr Lys Lys

770 775 780ctg gct ctg ggc atc ggt gta cag ggc ctg atg aac gtc cag tac gca 2400Leu Ala Leu Gly Ile Gly Val Gln Gly Leu Met Asn Val Gln Tyr Ala785 790 795 800ctc aag gac gac atc ctc tac gtc atc gag gca aac cca cgt gca tcc 2448Leu Lys Asp Asp Ile Leu Tyr Val Ile Glu Ala Asn Pro Arg Ala Ser

805 810 815cgc acc gtg ccg ttc gtc tcc aag gca acg ggc gtc aac ctg gcc aag 2496Arg Thr Val Pro Phe Val Ser Lys Ala Thr Gly Val Asn Leu Ala Lys

820 825 830gca gca tcc cgt atc gca gtg ggc gcc acc atc aag gat ctc caa gat 2544Ala Ala Ser Arg Ile Ala Val Gly Ala Thr Ile Lys Asp Leu Gln Asp

835 840 845gag ggc atg att cct acc gag tac gac ggc ggc tcc ttg cca ctg gac 2592Glu Gly Met Ile Pro Thr Glu Tyr Asp Gly Gly Ser Leu Pro Leu Asp

850 855 860gct cca atc gct gtg aag gaa gca gtg ttg ccg ttc aac cgc ttc cgt 2640Ala Pro Ile Ala Val Lys Glu Ala Val Leu Pro Phe Asn Arg Phe Arg865 870 875 880cgc cca gat gga aag acc ctg gac acc ctg ctt tcc cca gag atg aag 2688Arg Pro Asp Gly Lys Thr Leu Asp Thr Leu Leu Ser Pro Glu Met Lys

885 890 895tcc act ggc gag gtc atg ggc ttg gcc aac aac ttc ggc gct gca tat 2736Ser Thr Gly Glu Val Met Gly Leu Ala Asn Asn Phe Gly Ala Ala Tyr

900 905 910gca aag gct gaa gct ggc gcg ttt ggt gca ttg cca acc gaa ggc acc 2784Ala Lys Ala Glu Ala Gly Ala Phe Gly Ala Leu Pro Thr Glu Gly Thr

915 920 925gtc ttc gtg acc gtg gct aac cgc gac aag cgc acc ctg atc ctg cca 2832Val Phe Val Thr Val Ala Asn Arg Asp Lys Arg Thr Leu Ile Leu Pro

930 935 940atc cag cgc ctg gcg ttg atg ggc tac aag atc ctc gcc acc gaa ggc 2880Ile Gln Arg Leu Ala Leu Met Gly Tyr Lys Ile Leu Ala Thr Glu Gly945 950 955 960acc gca ggc atg ctg cgc cgc aac ggc att gag tgt gaa gtt gtg ctc 2928Thr Ala Gly Met Leu Arg Arg Asn Gly Ile Glu Cys Glu Val Val Leu

965 970 975aag gct tcc gac atc cgc gaa ggt gta gag ggc aag tcc atc gtg gat 2976Lys Ala Ser Asp Ile Arg Glu Gly Val Glu Gly Lys Ser Ile Val Asp

980 985 990cgt atc cgc gaa ggc gaa gtt gac ctc atc ctc aac acc cca gct ggt 3024Arg Ile Arg Glu Gly Glu Val Asp Leu Ile Leu Asn Thr Pro Ala Gly

995 1000 1005tct gct ggc gct cgc cac gat ggc tac gat atc cgc gca gca gca gtg 3072Ser Ala Gly Ala Arg His Asp Gly Tyr Asp Ile Arg Ala Ala Ala Val

1010 1015 1020acc gtg ggt gtt ccg ctg atc acc act gtt cag ggt gtc acc gca gct 3120Thr Val Gly Val Pro Leu Ile Thr Thr Val Gln Gly Val Thr Ala Ala1025 1030 1035 1040gtc cag ggc ata gag gcc ctg cgt gag ggc gtt gtc agc gtc cgc gcg 3168Val Gln Gly Ile Glu Ala Leu Arg Glu Gly Val Val Ser Val Arg Ala

1045 1050 1055ctg cag gaa ctc gac cac gca gtc aag gct taagccctat gacattcggc 3218Leu Gln Glu Leu Asp His Ala Val Lys Ala

10601065 gag 3221<210>1002<211>1066<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1002Gly Ser Asn Pro Ala Thr Ile Met Thr Asp Pro Glu Met Ala Asp His 151015 Thr Tyr Val Glu Pro Ile Glu Pro Glu Tyr Ile Asp Lys Ile Phe Ala

20 25 30Lys Glu Ile Glu Gln Gly His Pro Ile Asp Ala Val Leu Ala Thr Leu

35 40 45Gly Gly Gln Thr Ala Leu Asn Ala Ala Ile Gln Leu Asp Arg Leu Gly

50 55 60Ile Leu Glu Lys Tyr Gly Val Glu Leu Ile Gly Ala Asp Ile Asp Ala 65 70 75 80Ile Glu Arg Gly Glu Asp Arg Gln Lys Phe Lys Asp Ile Val Thr Thr

85 90 95Ile Gly Gly Glu Ser Ala Arg Ser Arg Val Cys His Asn Met Glu Glu

100 105 110Val His Glu Thr Val Ala Glu Leu Gly Leu Pro Val Val Val Arg Pro

115 120 125Ser Phe Thr Met Gly Gly Leu Gly Ser Gly Leu Ala Tyr Asn Thr Glu

130 135 140Asp Leu Glu Arg Ile Ala Gly Gly Gly Leu Ala Ala Ser Pro Glu Ala145 150 155 160Asn Val Leu Ile Glu Glu Ser Ile Leu Gly Trp Lys Glu Phe Glu Leu

165 170 175Glu Leu Met Arg Asp Thr Ala Asp Asn Val Val Val Ile Cys Ser Ile

180 185 190Glu Asn Val Asp Ala Leu Gly Val His Thr Gly Asp Ser Val Thr Val

195 200 205Ala Pro Ala Leu Thr Leu Thr Asp Arg Glu Phe Gln Lys Met Arg Asp

210 215 220Gln Gly Ile Ala Ile Ile Arg Glu Val Gly Val Asp Thr Gly Gly Cys225 230 235 240Asn Ile Gln Phe Ala Ile Asn Pro Val Asp Gly Arg Ile Ile Thr Ile

245 250 255Glu Met Asn Pro Arg Val Ser Arg Ser Ser Ala Leu Ala Ser Lys Ala

260 265 270Thr Gly Phe Pro Ile Ala Lys Met Ala Ala Lys Leu Ala Ile Gly Tyr

275 280 285Thr Leu Asp Glu Ile Thr Asn Asp Ile Thr Gly Glu Thr Pro Ala Ala

290 295 300Phe Glu Pro Thr Ile Asp Tyr Val Val Val Lys Ala Pro Arg Phe Ala305 310 315 320Phe Glu Lys Phe Val Gly Ala Asp Asp Thr Leu Thr Thr Thr Met Lys

325 330 335Ser Val Gly Glu Val Met Ser Leu Gly Arg Asn Tyr Ile Ala Ala Leu

340 345 350Asn Lys Ala Leu Arg Ser Leu Glu Thr Lys Gln Gln Gly Phe Trp Thr

355360 365Lys Pro Asp Glu Phe Phe Ala Gly Glu Arg Ala Thr Asp Lys Ala Ala

370 375 380Val Leu Glu Asp Leu Lys Arg Pro Thr Glu Gly Arg Leu Tyr Asp Val385 390 395 400Glu Leu Ala Met Arg Leu Gly Ala Ser Val Glu Glu Leu Tyr Glu Ala

405 410 415Ser Ser Ile Asp Pro Trp Phe Leu Ala Glu Leu Glu Ala Leu Val Gln

420 425 430Phe Arg Gln Lys Leu Val Asp Ala Pro Phe Leu Asn Glu Asp Leu Leu

435 440 445Arg Glu Ala Lys Phe Met Gly Leu Ser Asp Leu Gln Ile Ala Ala Leu

450 455 460Arg Pro Glu Phe Ala Gly Glu Asp Gly Val Arg Thr Leu Arg Leu Ser465 470 475 480Leu Gly Ile Arg Pro Val Phe Lys Thr Val Asp Thr Cys Ala Ala Glu

485 490 495Phe Glu Ala Lys Thr Pro Tyr His Tyr Ser Ala Tyr Glu Leu Asp Pro

500 505 510Ala Ala Glu Ser Glu Val Ala Pro Gln Thr Glu Arg Glu Lys Val Leu

515 520 525Ile Leu Gly Ser Gly Pro Asn Arg Ile Gly Gln Gly Ile Glu Phe Asp

530 535 540Tyr Ser Cys Val His Ala Ala Leu Glu Leu Ser Arg Val Gly Tyr Glu545 550 555 560Thr Val Met Val Asn Cys Asn Pro Glu Thr Val Ser Thr Asp Tyr Asp

565 570 575Thr Ala Asp Arg Leu Tyr Phe Glu Pro Leu Thr Phe Glu Asp Val Met

580 585 590Glu Val Tyr His Ala Glu Ala Gln Ser Gly Thr Val Ala Gly Val Ile

595 600 605Val Gln Leu Gly Gly Gln Thr Pro Leu Gly Leu Ala Asp Arg Leu Lys

610 615 620Lys Ala Gly Val Pro Val Ile Gly Thr Ser Pro Glu Ala Ile Asp Met625 630 635 640Ala Glu Asp Arg Gly Glu Phe Gly Ala Leu Leu Asn Arg Glu Gln Leu

645 650 655Pro Ala Pro Ala Phe Gly Thr Ala Thr Ser Phe Glu Glu Ala Arg Thr

660 665 670Val Ala Asp Glu Ile Ser Tyr Pro Val Leu Val Arg Pro Ser Tyr Val

675 680 685Leu Gly Gly Arg Gly Met Glu Ile Val Tyr Asp Glu Ala Ser Leu Glu

690 695 700Asp Tyr Ile Asn Arg Ala Thr Glu Leu Ser Ser Asp His Pro Val Leu705 710 715 720Val Asp Arg Phe Leu Asp Asn Ala Ile Glu Ile Asp Val Asp Ala Leu

725 730 735Cys Asp Gly Asp Glu Val Tyr Leu Ala Gly Val Met Glu His Ile Glu

740 745 750Glu Ala Gly Ile His Ser Gly Asp Ser Ala Cys Ala Leu Pro Pro Met

755 760 765Thr Leu Gly Ala Gln Asp Ile Glu Lys Val Arg Glu Ala Thr Lys Lys

770 775 780Leu Ala Leu Gly Ile Gly Val Gln Gly Leu Met Asn Val Gln Tyr Ala785 790 795 800Leu Lys Asp Asp Ile Leu Tyr Val Ile Glu Ala Asn Pro Arg Ala Ser

805 810 815Arg Thr Val Pro Phe Val Ser Lys Ala Thr Gly Val Asn Leu Ala Lys

820 825 830Ala Ala Ser Arg Ile Ala Val Gly Ala Thr Ile Lys Asp Leu Gln Asp

835 840 845Glu Gly Met Ile Pro Thr Glu Tyr Asp Gly Gly Ser Leu Pro Leu Asp

850 855 860Ala Pro Ile Ala Val Lys Glu Ala Val Leu Pro Phe Asn Arg Phe Arg865 870 875 880Arg Pro Asp Gly Lys Thr Leu Asp Thr Leu Leu Ser Pro Glu Met Lys

885 890 895Ser Thr Gly Glu Val Met Gly Leu Ala Asn Asn Phe Gly Ala Ala Tyr

900 905 910Ala Lys Ala Glu Ala Gly Ala Phe Gly Ala Leu Pro Thr Glu Gly Thr

915 920 925Val Phe Val Thr Val Ala Asn Arg Asp Lys Arg Thr Leu Ile Leu Pro

930 935 940Ile Gln Arg Leu Ala Leu Met Gly Tyr Lys Ile Leu Ala Thr Glu Gly945 950 955 960Thr Ala Gly Met Leu Arg Arg Asn Gly Ile Glu Cys Glu Val Val Leu

965 970 975Lys Ala Ser Asp Ile Arg Glu Gly Val Glu Gly Lys Ser Ile Val Asp

980 985 990Arg Ile Arg Glu Gly Glu Val Asp Leu Ile Leu Asn Thr Pro Ala Gly

995 1000 1005Ser Ala Gly Ala Arg His Asp Gly Tyr Asp Ile Arg Ala Ala Ala Val

1010 1015 1020Thr Val Gly Val Pro Leu Ile Thr Thr Val Gln Gly Val Thr Ala Ala10251030 1035 1040Val Gln Gly Ile Glu Ala Leu Arg Glu Gly Val Val Ser Val Arg Ala

1045 1050 1055Leu Gln Glu Leu Asp His Ala Val Lys Ala

10601065<210>1003<211>424<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (424)<223>RXN00450<400>1003tttgcgatga catggatttg gatccttccg aacaattgct gcgcatcgcg gaagaactcg 60gttttgataa tgatctggct cgggtggtgg gattcgacta gtg ggc gtt tta cct 115

Val Gly Val Leu Pro

1 5gtg cag gcg cgc atc aaa gac gat gag cgc cgc atg cgc cat gct ttg 163Val Gln Ala Arg Ile Lys Asp Asp Glu Arg Arg Met Arg His Ala Leu

10 15 20gat att gct cgc caa acc cct gag ggg gac gtt ccc gtt ggc gcc gtc 211Asp Ile Ala Arg Gln Thr Pro Glu Gly Asp Val Pro Val Gly Ala Val

25 30 35att tac gcg ccg acc ggg gag atc ctg gcg acc gca acg aac cgt cga 259Ile Tyr Ala Pro Thr Gly Glu Ile Leu Ala Thr Ala Thr Asn Arg Arg

40 45 50gaa gca gac cgc gat ccc acg gcc cac gcc gaa att att gct tta cga 307Glu Ala Asp Arg Asp Pro Thr Ala His Ala Glu Ile Ile Ala Leu Arg

55 60 65cga gcc gcc cgc cgt ttt tcc gac ggc tgg cgg ctg agt gac tgc acc 355Arg Ala Ala Arg Arg Phe Ser Asp Gly Trp Arg Leu Ser Asp Cys Thr 70 75 80 85gcg gtg gtc acc ttg gag ccc tgc agt atg tgc gcc ggc gcc ttg gtg 403Ala Val Val Thr Leu Glu Pro Cys Ser Met Cys Ala Gly Ala Leu Val

90 95 100ggt gct cga atc gga cgc atc 424Gly Ala Arg Ile Gly Arg Ile

105<210>1004<211>108<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1004Val Gly Val Leu Pro Val Gln Ala Arg Ile Lys Asp Asp Glu Arg Arg 151015 Met Arg His Ala Leu Asp Ile Ala Arg Gln Thr Pro Glu Gly Asp Val

20 25 30Pro Val Gly Ala Val Ile Tyr Ala Pro Thr Gly Glu Ile Leu Ala Thr

35 40 45Ala Thr Asn Arg Arg Glu Ala Asp Arg Asp Pro Thr Ala His Ala Glu

50 55 60 Ile Ile Ala Leu Arg Arg Ala Ala Arg Arg Phe Ser Asp Gly Trp Arg 65 70 75 80Leu Ser Asp Cys Thr Ala Val Val Thr Leu Glu Pro Cys Ser Met Cys

85 90 95Ala Gly Ala Leu Val Gly Ala Arg Ile Gly Arg Ile

100105<210>1005<211>418<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (418)<223>FRXA00450<400>1005tttgcgatga catggatttg gatccttccg aacaattgct gcgcatcgcg gaagaactcg 60gttttgataa tgatctggct cgggtggtgg gattcgacta gtg ggc gtt tta cct 115

Val Gly Val Leu Pro

1 5gtg cag gcg cgc atc aaa gac gat gag cgc cgc atg cgc cat gct ttg 163Val Gln Ala Arg Ile Lys Asp Asp Glu Arg Arg Met Arg His Ala Leu

1015 20gat att gct cgc caa acc cct gag ggg gac gtt ccc gtt ggc gcc gtc 211Asp Ile Ala Arg Gln Thr Pro Glu Gly Asp Val Pro Val Gly Ala Val

25 30 35att tac gcg ccg acc ggg gag atc ctg gcg acc gca acg aac cgt cga 259Ile Tyr Ala Pro Thr Gly Glu Ile Leu Ala Thr Ala Thr Asn Arg Arg

40 45 50gaa gca gac cgc gat ccc acg gcc cac gcc gaa att att gct tta cga 307Glu Ala Asp Arg Asp Pro Thr Ala His Ala Glu Ile Ile Ala Leu Arg

55 60 65cga gcc gcc cgc cgt ttt tcc gac ggc tgg cgg ctg agt gac tgc acc 355Arg Ala Ala Arg Arg Phe Ser Asp Gly Trp Arg Leu Ser Asp Cys Thr 70 75 80 85gcg gtg gtc acc ttg gag ccc tgc agt atg tgc gcc ggc gcc ttg gtg 403Ala Val Va lThr Leu Glu Pro Cys Ser Met Cys Ala Gly Ala Leu Val

90 95 100ggt gct cga atc gga 418Gly Ala Arg Ile Gly

105<210>1006<211>106<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1006Val Gly Val Leu Pro Val Gln Ala Arg Ile Lys Asp Asp Glu Arg Arg 151015 Met Arg His Ala Leu Asp Ile Ala Arg Gln Thr Pro Glu Gly Asp Val

20 25 30Pro Val Gly Ala Val Ile Tyr Ala Pro Thr Gly Glu Ile Leu Ala Thr

35 40 45Ala Thr Asn Arg Arg Glu Ala Asp Arg Asp Pro Thr Ala His Ala Glu

50 55 60Ile Ile Ala Leu Arg Arg Ala Ala Arg Arg Phe Ser Asp Gly Trp Arg 65 70 75 80Leu Ser Asp Cys ThrAla Val Val Thr Leu Glu Pro Cys Ser Met Cys

85 90 95Ala Gly Ala Leu Val Gly Ala Arg Ile Gly

100105<210>1007<211>1368<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1345)<223>RXN02272<400>1007tatttaactc cacactaata cctgtcaagc aatagaatag atagcatctg gatcctccag 60agtttgaaaa tatgccttga catgtagaaa tggagttctt gtg cgc att aca aac 115

Val Arg Ile Thr Asn

1 5gcc cag gtt aag aac tac gca gag tta gtt gat ate acc ata gag ggt 163Ala Gln Val Lys Asn Tyr Ala Glu Leu Val Asp Ile Thr Ile Glu Gly

10 15 20gaa aaa att tcc tcg att acc ccc tct tca att cga tca gaa gaa gat 211Glu Lys Ile Ser Ser Ile Thr Pro Ser Ser Ile Arg Ser Glu Glu Asp

25 30 35cac cgc gcg gac gat tac gat gcc gca gga aga ctg gtc gca ccc cag 259His Arg Ala Asp Asp Tyr Asp Ala Ala Gly Arg Leu Val Ala Pro Gln

40 45 50ttc gcc gaa gca cac atc cac ctt gac tac gca aac acc gct gga atc 307Phe Ala Glu Ala His Ile His Leu Asp Tyr Ala Asn Thr Ala Gly Ile

55 60 65cct cgc gaa aac tct tcc ggc aca ctt ttt gaa gcc atc gaa atc tgg 355Pro Arg Glu Asn Ser Ser Gly Thr Leu Phe Glu Ala Ile Glu Ile Trp 70 75 80 85gcc gac cgc aag acc caa ggc ttc cac atc aaa gaa gac att aaa gcg 403Ala Asp Arg Lys Thr Gln Gly Phe His Ile Lys Glu Asp Ile Lys Ala

9095 100aag gcc ctc cag gca gcc cgt cgg gca gca gaa cac ggc gtt ggt ttc 451Lys Ala Leu Gln Ala Ala Arg Arg Ala Ala Glu His Gly Val Gly Phe

105 110 115atc cgc act cac gta gat gtc acc gat ccc acg ttt gct gga ttc gaa 499Ile Arg Thr His Val Asp Val Thr Asp Pro Thr Phe Ala Gly Phe Glu

120 125 130gca att gcg gag ctg cgc gat gaa gtc cgc gag tgg tgc gat atc cag 547Ala Ile Ala Glu Leu Arg Asp Glu Val Arg Glu Trp Cys Asp Ile Gln

135 140 145att gtc gcc ttc ccg caa aat ggc att tac gcc tac gaa ggt ggc cag 595Ile Val Ala Phe Pro Gln Asn Gly Ile Tyr Ala Tyr Glu Gly Gly Gln150 155 160 165aag cta atc tca gat gca atg tct gca ggt gca gat gtc gtt ggt ggc 643Lys Leu Ile Ser Asp Ala Met Ser Ala Gly Ala Asp Val Val Gly Gly

170 175 180atc cca cac ctt gaa ccc acc cga gac gat ggc gtc gag tcg gtg aaa 691Ile Pro His Leu Glu Pro Thr Arg Asp Asp Gly Val Glu Ser Val Lys

185 190 195tgg ctg ttc gac ctt gca gag aag cac tca gcc ccc atc gat atc cac 739Trp Leu Phe Asp Leu Ala Glu Lys His Ser Ala Pro Ile Asp Ile His

200 205 210act gat gaa att gac gat cca cat tcc cga ttt gtc gaa gtc ctc gcc 787Thr Asp Glu Ile Asp Asp Pro His Ser Arg Phe Val Glu Val Leu Ala

215 220 225gca gaa gcc gca aaa cgt gac atg ggc gca caa acc gtg gtg tct cat 835Ala Glu Ala Ala Lys Arg Asp Met Gly Ala Gln Thr Val Val Ser His230 235 240 245tct gtg gcg atg gcc tat tac tca cct ggc tac atg gcg cga ctt tta 883Ser Val Ala Met Ala Tyr Tyr Ser Pro Gly Tyr Met Ala Arg Leu Leu

250 255 260ccc aag ctc gca gca tca aag gtt cgt ttt gca gta tgc ccc aat gaa 931Pro Lys Leu Ala Ala Ser Lys Val Arg Phe Ala Val Cys Pro Asn Glu

265 270 275aac ctc cat ctg caa gga ctt ggt ttc caa gga ccc gtc ccc cga ggt 979Asn Leu His Leu Gln Gly Leu Gly Phe Gln Gly Pro Val Pro Arg Gly

280 285 290gtt gca ccg gta aag caa ctt acc gaa tgg gga att cca gta agt ttt 1027Val Ala Pro Val Lys Gln Leu Thr Glu Trp Gly Ile Pro Val Ser Phe

295 300 305tgc cag gac tca ctc aat gac ccc ttc tac ccc atg ggc gat gga gat 1075Cys Gln Asp Ser Leu Asn Asp Pro Phe Tyr Pro Met Gly Asp Gly Asp310 315 320 325cta ctc cgc att ctc gat tct gga tta cac gtg tcc cac atg ctc aca 1123Leu Leu Arg Ile Leu Asp Ser Gly Leu His Val Ser His Met Leu Thr

330 335 340gcc agc cac ttg aag aat gca cta tcg ttc atc acc acc aat cca gcc 1171Ala Ser His Leu Lys Asn Ala Leu Ser Phe Ile Thr Thr Asn Pro Ala

345 350 355gga aac cta ggc ctg gac aat tac gac att gca gaa aac tcc ccg gcg 1219Gly Asn Leu Gly Leu Asp Asn Tyr Asp Ile Ala Glu Asn Ser Pro Ala

360 365 370aac ctg ctg gtt ctt gat gcg agc agc gag aag gaa gct gta cag aga 1267Asn Leu Leu Val Leu Asp Ala Ser Ser Glu Lys Glu Ala Val Gln Arg

375 380 385aaa gct tcc gta ctt ttg agc atc cac cgc ggc aaa aag gtg ctc tcc 1315Lys Ala Ser Val Leu Leu Ser Ile His Arg Gly Lys Lys Val Leu Ser390 395400 405agg gag ccc gaa cag gtg gac tgg aac atc taacagccca gttgggcctc 1365Arg Glu Pro Glu Gln Val Asp Trp Asn Ile

410415 ctt 1368<210>1008<211>415<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1008Val Arg Ile Thr Asn Ala Gln Val Lys Asn Tyr Ala Glu Leu Val Asp 151015 Ile Thr Ile Glu Gly Glu Lys Ile Ser Ser Ile Thr Pro Ser Ser Ile

20 25 30Arg Ser Glu Glu Asp His Arg Ala Asp Asp Tyr Asp Ala Ala Gly Arg

35 40 45Leu Val Ala Pro Gln Phe Ala Glu Ala His Ile His Leu Asp Tyr Ala

50 55 60Asn Thr Ala Gly Ile Pro Arg Glu Asn Ser Ser Gly Thr Leu Phe Glu 65 70 75 80Ala Ile Glu Ile Trp Ala Asp Arg Lys Thr Gln Gly Phe His Ile Lys

85 90 95Glu Asp Ile Lys Ala Lys Ala Leu Gln Ala Ala Arg Arg Ala Ala Glu

100 105 110His Gly Val Gly Phe Ile Arg Thr His Val Asp Val Thr Asp Pro Thr

115 120 125Phe Ala Gly Phe Glu Ala Ile Ala Glu Leu Arg Asp Glu Val Arg Glu

130 135 140Trp Cys Asp Ile Gln Ile Val Ala Phe Pro Gln Asn Gly Ile Tyr Ala145 150 155 160Tyr Glu Gly Gly Gln Lys Leu Ile Ser Asp Ala Met Ser Ala Gly Ala

165 170 175Asp Val Val Gly Gly Ile Pro His Leu Glu Pro Thr Arg Asp Asp Gly

180 185190Val Glu Ser Val Lys Trp Leu Phe Asp Leu Ala Glu Lys His Ser Ala

195 200 205Pro Ile Asp Ile His Thr Asp Glu Ile Asp Asp Pro His Ser Arg Phe

210 215 220Val Glu Val Leu Ala Ala Glu Ala Ala Lys Arg Asp Met Gly Ala Gln225 230 235 240Thr Val Val Ser His Ser Val Ala Met Ala Tyr Tyr Ser Pro Gly Tyr

245 250 255Met Ala Arg Leu Leu Pro Lys Leu Ala Ala Ser Lys Val Arg Phe Ala

260 265 270Val Cys Pro Asn Glu Asn Leu His Leu Gln Gly Leu Gly Phe Gln Gly

275 280 285Pro Val Pro Arg Gly Val Ala Pro Val Lys Gln Leu Thr Glu Trp Gly

290 295 300Ile Pro Val Ser Phe Cys Gln Asp Ser Leu Asn Asp Pro Phe Tyr Pro305 310 315 320Met Gly Asp Gly Asp Leu Leu Arg Ile Leu Asp Ser Gly Leu His Val

325 330 335Ser His Met Leu Thr Ala Ser His Leu Lys Asn Ala Leu Ser Phe Ile

340 345 350Thr Thr Asn Pro Ala Gly Asn Leu Gly Leu Asp Asn Tyr Asp Ile Ala

355 360 365Glu Asn Ser Pro Ala Asn Leu Leu Val Leu Asp Ala Ser Ser Glu Lys

370 375 380Glu Ala Val Gln Arg Lys Ala Ser Val Leu Leu Ser Ile His Arg Gly385 390 395 400Lys Lys Val Leu Ser Arg Glu Pro Glu Gln Val Asp Trp Asn Ile

405410415<210>1009<211>1368<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1345)<223>FRXA02272<400>1009tatttaactc cacactaata cctgtcaagc aatagaatag atagcatctg gatcctccag 60agtttgaaaa tatgccttga catgtagaaa tggagttctt gtg cgc att aca aac 115

Val Arg Ile Thr Asn

1 5gcc cag gtt aag aac tac gca gag tta gtt gat atc acc ata gag ggt 163Ala Gln Val Lys Asn Tyr Ala Glu Leu Val Asp Ile Thr Ile Glu Gly

10 15 20gaa aaa att tcc tcg att acc ccc tct tca att cga tca gaa gaa gat 211Glu Lys Ile Ser Ser Ile Thr Pro Ser Ser Ile Arg Ser Glu Glu Asp

25 30 35cac cgc gcg gac gat tac gat gcc gca gga aga ctg gtc gca ccc cag 259His Arg Ala Asp Asp Tyr Asp Ala Ala Gly Arg Leu Val Ala Pro Gln

40 45 50ttc gcc gaa gca cac atc cac ctt gac tac gca aac acc gct gga atc 307Phe Ala Glu Ala His Ile His Leu Asp Tyr Ala Asn Thr Ala Gly Ile

55 60 65cct cgc gaa aac tct tcc ggc aca ctt ttt gaa gcc atc gaa atc tgg 355Pro Arg Glu Asn Ser Ser Gly Thr Leu Phe Glu Ala Ile Glu Ile Trp 70 75 80 85gcc gac cgc aag acc caa ggc ttc cac atc aaa gaa gac att aaa gcg 403Ala Asp Arg Lys Thr Gln Gly Phe His Ile Lys Glu Asp Ile Lys Ala

90 95 100aag gcc ctc cag gca gcc cgt cgg gca gca gaa cac ggc gtt ggt ttc 451Lys Ala Leu Gln Ala Ala Arg Arg Ala Ala Glu His Gly Val Gly Phe

105 110 115atc cgc act cac gta gat gtc acc gat ccc acg ttt gct gga ttc gaa 499Ile Arg Thr His Val Asp Val Thr Asp Pro Thr Phe Ala Gly Phe Glu

120 125 130gca att gcg gag ctg cgc gat gaa gtc cgc gag tgg tgc gat atc cag 547Ala Ile Ala Glu Leu Arg Asp Glu Val Arg Glu Trp Cys Asp Ile Gln

135 140 145att gtc gcc ttc ccg caa aat ggc att tac gcc tac gaa ggt ggc cag 595Ile Val Ala Phe Pro Gln Asn Gly Ile Tyr Ala Tyr Glu Gly Gly Gln150 155 160 165aag cta atc tca gat gca atg tct gca ggt gca gat gtc gtt ggt ggc 643Lys Leu Ile Ser Asp Ala Met Ser Ala Gly Ala Asp Val Val Gly Gly

170 175 180atc cca cac ctt gaa ccc acc cga gac gat ggc gtc gag tcg gtg aaa 691Ile Pro His Leu Glu Pro Thr Arg Asp Asp Gly Val Glu Ser Val Lys

185 190 195tgg ctg ttc gac ctt gca gag aag cac tca gcc ccc atc gat atc cac 739Trp Leu Phe Asp Leu Ala Glu Lys His Ser Ala Pro Ile Asp Ile His

200 205 210act gat gaa att gac gat cca cat tcc cga ttt gtc gaa gtc ctc gcc 787Thr Asp Glu Ile Asp Asp Pro His Ser Arg Phe Val Glu Val Leu Ala

215 220 225gca gaa gcc gca aaa cgt gac atg ggc gca caa acc gtg gtg tct cat 835Ala Glu Ala Ala Lys Arg Asp Met Gly Ala Gln Thr Val Val Ser His230 235 240 245tct gtg gcg atg gcc tat tac tca cct ggc tac atg gcg cga ctt tta 883Ser Val Ala Met Ala Tyr Tyr Ser Pro Gly Tyr Met Ala Arg Leu Leu

250 255 260ccc aag ctc gca gca tca aag gtt cgt ttt gca gta tgc ccc aat gaa 931Pro Lys Leu Ala Ala Ser Lys Val Arg Phe Ala Val Cys Pro Asn Glu

265 270 275aac ctc cat ctg caa gga ctt ggt ttc caa gga ccc gtc ccc cga ggt 979Asn Leu His Leu Gln Gly Leu Gly Phe Gln Gly Pro Val Pro Arg Gly

280 285 290gtt gca ccg gta aag caa ctt acc gaa tgg gga att cca gta agt ttt 1027Val Ala Pro Val Lys Gln Leu Thr Glu Trp Gly Ile Pro Val Ser Phe

295 300 305tgc cag gac tca ctc aat gac ccc ttc tac ccc atg ggc gat gga gat 1075Cys Gln Asp Ser Leu Asn Asp Pro Phe Tyr Pro Met Gly Asp Gly Asp310 315 320 325cta ctc cgc att ctc gat tct gga tta cac gtg tcc cac atg ctc aca 1123Leu Leu Arg Ile Leu Asp Ser Gly Leu His Val Ser His Met Leu Thr

330 335 340gcc agc cac ttg aag aat gca cta tcg ttc atc acc acc aat cca gcc 1171Ala Ser His Leu Lys Asn Ala Leu Ser Phe Ile Thr Thr Asn Pro Ala

345 350 355gga aac cta ggc ctg gac aat tac gac att gca gaa aac tcc ccg gcg 1219Gly Asn Leu Gly Leu Asp Asn Tyr Asp Ile Ala Glu Asn Ser Pro Ala

360 365 370aac ctg ctg gtt ctt gat gcg agc agc gag aag gaa gct gta cag aga 1267Asn Leu Leu Val Leu Asp Ala Ser Ser Glu Lys Glu Ala Val Gln Arg

375 380 385aaa gct tcc gta ctt ttg agc atc cac cgc ggc aaa aag gtg ctc tcc 1315Lys Ala Ser Val Leu Leu Ser Ile His Arg Gly Lys Lys Val Leu Ser390 395 400 405agg gag ccc gaa cag gtg gac tgg aac atc taacagccca gttgggcctc 1365Arg Glu Pro Glu Gln Val Asp Trp Asn Ile

410415 ctt 1368<210>1010<211>415<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1010Val Arg Ile Thr Asn Ala Gln Val Lys Asn Tyr Ala Glu Leu Val Asp 151015 Ile Thr Ile Glu Gly Glu Lys Ile Ser Ser Ile Thr Pro Ser Ser Ile

20 25 30Arg Ser Glu Glu Asp His Arg Ala Asp Asp Tyr Asp Ala Ala Gly Arg

35 40 45Leu Val Ala Pro Gln Phe Ala Glu Ala His Ile His Leu Asp Tyr Ala

50 55 60Asn Thr Ala Gly Ile Pro Arg Glu Asn Ser Ser Gly Thr Leu Phe Glu 65 70 75 80Ala Ile Glu Ile Trp Ala Asp Arg Lys Thr Gln Gly Phe His Ile Lys

85 90 95Glu Asp Ile Lys Ala Lys Ala Leu Gln Ala Ala Arg Arg Ala Ala Glu

100 105 110His Gly Val Gly Phe Ile Arg Thr His Val Asp Val Thr Asp Pro Thr

115 120 125Phe Ala Gly Phe Glu Ala Ile Ala Glu Leu Arg Asp Glu Val Arg Glu

130 135 140Trp Cys Asp Ile Gln Ile Val Ala Phe Pro Gln Asn Gly Ile Tyr Ala145 150 155 160Tyr Glu Gly Gly Gln Lys Leu Ile Ser Asp Ala Met Ser Ala Gly Ala

165 170 175Asp Val Val Gly Gly Ile Pro His Leu Glu Pro Thr Arg Asp Asp Gly

180 185 190Val Glu Ser Val Lys Trp Leu Phe Asp Leu Ala Glu Lys His Ser Ala

195 200 205Pro Ile Asp Ile His Thr Asp Glu Ile Asp Asp Pro His Ser Arg Phe

210 215 220Val Glu Val Leu Ala Ala Glu Ala Ala Lys Arg Asp Met Gly Ala Gln225 230 235 240Thr Val Val Ser His Ser Val Ala Met Ala Tyr Tyr Ser Pro Gly Tyr

245 250 255Met Ala Arg Leu Leu Pro Lys Leu Ala Ala Ser Lys Val Arg Phe Ala

260 265 270Val Cys Pro Asn Glu Asn Leu His Leu Gln Gly Leu Gly Phe Gln Gly

275 280 285Pro Val Pro Arg Gly Val Ala Pro Val Lys Gln Leu Thr Glu Trp Gly

290 295 300Ile Pro Val Ser Phe Cys Gln Asp Ser Leu Asn Asp Pro Phe Tyr Pro305 310 315 320Met Gly Asp Gly Asp Leu Leu Arg Ile Leu Asp Ser Gly Leu His Val

325 330 335Ser His Met Leu Thr Ala Ser His Leu Lys Asn Ala Leu Ser Phe Ile

340 345 350Thr Thr Asn Pro Ala Gly Asn Leu Gly Leu Asp Asn Tyr Asp Ile Ala

355 360 365Glu Asn Ser Pro Ala Asn Leu Leu Val Leu Asp Ala Ser Ser Glu Lys

370 375 380Glu Ala Val Gln Arg Lys Ala Ser Val Leu Leu Ser Ile His Arg Gly385 390 395 400Lys Lys Val Leu Ser Arg Glu Pro Glu Gln Val Asp Trp Asn Ile

405410415<210>1011<211>580<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (580)<223>RXN03004<400>1011gctagcacga taaaaatcag cgccagcacc acgcgcccca ggaacctcat cgcagcaacc 60cgtggcccaa ccctgaacgc tgaacgctac actggttgac gtg ctt ctt tca gat 115

Val Leu Leu Ser Asp

1 5cgt gac att cgt aaa tca att gac gca ggc gac ttg gga att gaa cct 163Arg Asp Ile Arg Lys Ser Ile Asp Ala Gly Asp Leu Gly Ile Glu Pro

10 15 20ttc gac gct gag ctg att cag ccg tcg agt gtc gat gtc cgc atg gac 211Phe Asp Ala Glu Leu Ile Gln Pro Ser Ser Val Asp Val Arg Met Asp

25 30 35cgc tac ttc cgg gtt ttc aat aac tct aag tac acc cac att gac cct 259Arg Tyr Phe Arg Val Phe Asn Asn Ser Lys Tyr Thr His Ile Asp Pro

40 45 50aag ttg aat cag gat gag ctg acc agc ctt gtt gag gtt gag gac ggc 307Lys Leu Asn Gln Asp Glu Leu Thr Ser Leu Val Glu Val Glu Asp Gly

55 60 65gag ggc ttt gtg ctg cat ccg ggt gag ttt gtg ctg gcg tcc acg ctg 355Glu Gly Phe Val Leu His Pro Gly Glu Phe Val Leu Ala Ser Thr Leu 70 75 80 85gaa aag ttc act ttg cct gcg cat ctg gct ggt cgt ttg gag ggt aag 403Glu Lys Phe Thr Leu Pro Ala His Leu Ala Gly Arg Leu Glu Gly Lys

90 95 100tcg tct ctt ggt cgt ctt ggc ttg ttg acg cac tct act gct ggt ttc 451Ser Ser Leu Gly Arg Leu Gly Leu Leu Thr His Ser Thr Ala Gly Phe

105 110 115att gat cct ggt ttt agt ggt tac atc acg ttg gag ttg tcc aat gtg 499Ile Asp Pro Gly Phe Ser Gly Tyr Ile Thr Leu Glu Leu Ser Asn Val

120 125 130gct aat ctg ccg atc acg ttg tgg ccg ggt atg aag gtg ggg cag ctg 547Ala Asn Leu Pro Ile ThrLeu Trp Pro Gly Met Lys Val Gly Gln Leu

135140145 gct ttg ttc cag atg agt tcc cct gcg gag act 580Ala Leu Phe Gln Met Ser Ser Pro Ala Glu Thr 150155160<210>1012<211>160<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1012Val Leu Leu Ser Asp Arg Asp Ile Arg Lys Ser Ile Asp Ala Gly Asp 151015 Leu Gly Ile Glu Pro Phe Asp Ala Glu Leu Ile Gln Pro Ser Ser Val

20 25 30Asp Val Arg Met Asp Arg Tyr Phe Arg Val Phe Asn Asn Ser Lys Tyr

35 40 45Thr His Ile Asp Pro Lys Leu Asn Gln Asp Glu Leu Thr Ser Leu Val

50 55 60Glu Val Glu Asp Gly Glu Gly Phe Val Leu His Pro Gly Glu Phe Val 65 70 75 80Leu Ala Ser Thr Leu Glu Lys Phe Thr Leu Pro Ala His Leu Ala Gly

85 90 95Arg Leu Glu Gly Lys Ser Ser Leu Gly Arg Leu Gly Leu Leu Thr His

100 105 110Ser Thr Ala Gly Phe Ile Asp Pro Gly Phe Ser Gly Tyr Ile Thr Leu

115 120 125Glu Leu Ser Asn Val Ala Asn Leu Pro Ile Thr Leu Trp Pro Gly Met

130135140 Lys Val Gly Gln Leu Ala Leu Phe Gln Met Ser Ser Pro Ala Glu Thr 145150155160<210>1013<211>225<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (202)<223>RXN03137<400>1013cggcgagttc atttggactg gcggcgactg ccacatttat gacaaccaca aggaacaggt 60cgcggagcag ctgagccgat aagctcgccc ctaccccacc ttg gag ctc aac aag 115

Leu Glu Leu Asn Lys

1 5gca gcg tac atg ttt gag tac agc ttc gat gac atc acc gtg tcc ggc 163Ala Ala Tyr Met Phe Glu Tyr Ser Phe Asp Asp Ile Thr Val Ser Gly

10 15 20tac gat cca cac cca ttg atc cgc ggc aag gtc gcc gta tgatcggtgc 212Tyr Asp Pro His Pro Leu Ile Arg Gly Lys Val Ala Val

2530 gatttgggca caa 225<210>1014<211>34<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1014Leu Glu Leu Asn Lys Ala Ala Tyr Met Phe Glu Tyr Ser Phe Asp Asp 151015 Ile Thr Val Ser Gly Tyr Asp Pro His Pro Leu Ile Arg Gly Lys Val

202530 Ala Val<210>1015<211>613<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (613)<223>RXN03171<400>1015atactttgtt ggactggaaa agtggccgtt tggttccctc caagcccaaa ttcgcccgcg 60cggtcttctt ctgggcggca atgatttaac atgtgaagct atg gac atc acc atc 115

Met Asp Ile Thr Ile

1 5gtc aac cac cca ctc gtt gct agc cgc cta acc ctg ttg cgc gac gag 163Val Asn His Pro Leu Val Ala Ser Arg Leu Thr Leu Leu Arg Asp Glu

10 15 20cgc agc gac aac gca gct ttc cgt gca gca gcc aac gac ctc ggc gcc 211Arg Ser Asp Asn Ala Ala Phe Arg Ala Ala Ala Asn Asp Leu Gly Ala

25 30 35atg ctg atc tac gaa gca tcc cga gat ctg gaa gtc gaa cac ttc gac 259Met Leu Ile Tyr Glu Ala Ser Arg Asp Leu Glu Val Glu His Phe Asp

4045 50acc aaa acc ccc gtt gcc atg gct gaa ggt act cgc ctg aag cag cca 307Thr Lys Thr Pro Val Ala Met Ala Glu Gly Thr Arg Leu Lys Gln Pro

55 60 65ccc atc atc gtt ccc atc atc cgt gca ggt ctc ggc atg atc gac cca 355Pro Ile Ile Val Pro Ile Ile Arg Ala Gly Leu Gly Met Ile Asp Pro 70 75 80 85gcg ctg tcg atg att ccg gat gca cag gtc ggc ttc att ggc ctt gcc 403Ala Leu Ser Met Ile Pro Asp Ala Gln Val Gly Phe Ile Gly Leu Ala

90 95 100cgc gat gag gaa acc cat gag cca gtc cca tac ctt gag gcg ctg cca 451Arg Asp Glu Glu Thr His Glu Pro Val Pro Tyr Leu Glu Ala Leu Pro

105 110 115cag gat cta agc aac cag cct gta ttc ctt gtc gat ccc atg ctg gcc 499Gln Asp Leu Ser Asn Gln Pro Val Phe Leu Val Asp Pro Met Leu Ala

120 125 130acc ggc ggt tcc ctc ctg cac gcg atc cgc ctt ctt gct gat cgt ggc 547Thr Gly Gly Ser Leu Leu His Ala Ile Arg Leu Leu Ala Asp Arg Gly

135 140 145gcc acc gac atc acc gcc atc tgc atg gtt tct gcg cag cca ggt gtg 595Ala Thr Asp Ile Thr Ala Ile Cys Met Val Ser Ala Gln Pro Gly Val150 155 160 165gac gca ttg gcg gaa tct 613Asp Ala Leu Ala Glu Ser

170<210>1016<211>171<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1016Met Asp Ile Thr Ile Val Asn His Pro Leu Val Ala Ser Arg Leu Thr 151015 Leu Leu Arg Asp Glu Arg Ser Asp Asn Ala Ala Phe Arg Ala Ala Ala

20 25 30Asn Asp Leu Gly Ala Met Leu Ile Tyr Glu Ala Ser Arg Asp Leu Glu

35 40 45Val Glu His Phe Asp Thr Lys Thr Pro Val Ala Met Ala Glu Gly Thr

50 55 60Arg Leu Lys Gln Pro Pro Ile Ile Val Pro Ile Ile Arg Ala Gly Leu 65 70 75 80Gly Met Ile Asp Pro Ala Leu Ser Met Ile Pro Asp Ala Gln Val Gly

85 90 95Phe Ile Gly Leu Ala Arg Asp Glu Glu Thr His Glu Pro Val Pro Tyr

100 105 110Leu Glu Ala Leu Pro Gln Asp Leu Ser Asn Gln Pro Val Phe Leu Val

115 120 125Asp Pro Met Leu Ala Thr Gly Gly Ser Leu Leu His Ala Ile Arg Leu

130 135 140Leu Ala Asp Arg Gly Ala Thr Asp Ile Thr Ala Ile Cys Met Val Ser145 150 155 160Ala Gln Pro Gly Val Asp Ala Leu Ala Glu Ser

165170<210>1017<211>613<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (613)<223>FRXA02857<400>1017atactttgtt ggactggaaa agtggccgtt tggttccctc caagcccaaa ttcgcccgcg 60cggtcttctt ctgggcggca atgatttaac atgtgaagct atg gac atc acc atc 115

Met Asp Ile Thr Ile

1 5gtc aac cac cca ctc gtt gct agc cgc cta acc ctg ttg cgc gac gag 163Val Asn His Pro Leu Val Ala Ser Arg Leu Thr Leu Leu Arg Asp Glu

10 15 20cgc agc gac aac gca gct ttc cgt gca gca gcc aac gac ctcggc gcc 211Arg Ser Asp Asn Ala Ala Phe Arg Ala Ala Ala Asn Asp Leu Gly Ala

25 30 35atg ctg atc tac gaa gca tcc cga gat ctg gaa gtc gaa cac ttc gac 259Met Leu Ile Tyr Glu Ala Ser Arg Asp Leu Glu Val Glu His Phe Asp

40 45 50acc aaa acc ccc gtt gcc atg gct gaa ggt act cgc ctg aag cag cca 307Thr Lys Thr Pro Val Ala Met Ala Glu Gly Thr Arg Leu Lys Gln Pro

55 60 65ccc atc atc gtt ccc atc atc cgt gca ggt ctc ggc atg atc gac cca 355Pro Ile Ile Val Pro Ile Ile Arg Ala Gly Leu Gly Met Ile Asp Pro 70 75 80 85gcg ctg tcg atg att ccg gat gca cag gtc ggc ttc att ggc ctt gcc 403Ala Leu Ser Met Ile Pro Asp Ala Gln Val Gly Phe Ile Gly Leu Ala

90 95 100cgc gat gag gaa acc cat gag cca gtc cca tac ctt gag gcg ctg cca 451Arg Asp Glu Glu Thr His Glu Pro Val Pro Tyr Leu Glu Ala Leu Pro

105 110 115cag gat cta agc aac cag cct gta ttc ctt gtc gat ccc atg ctg gcc 499Gln Asp Leu Ser Asn Gln Pro Val Phe Leu Val Asp Pro Met Leu Ala

120 125 130acc ggc ggt tcc ctc ctg cac gcg atc cgc ctt ctt gct gat cgt ggc 547Thr Gly Gly Ser Leu Leu His Ala Ile Arg Leu Leu Ala Asp Arg Gly

135 140 145gcc acc gac atc acc gcc atc tgc atg gtt tct gcg cag cca ggt gtg 595Ala Thr Asp Ile Thr Ala Ile Cys Met Val Ser Ala Gln Pro Gly Val150 155 160 165gac gca ttg gcg gaa tct 613Asp Ala Leu Ala Glu Ser

170<210>1018<211>171<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1018Met Asp Ile Thr Ile Val Asn His Pro Leu Val Ala Ser Arg Leu Thr 151015 Leu Leu Arg Asp Glu Arg Ser Asp Asn Ala Ala Phe Arg Ala Ala Ala

20 25 30Asn Asp Leu Gly Ala Met Leu Ile Tyr Glu Ala Ser Arg Asp Leu Glu

35 40 45Val Glu His Phe Asp Thr Lys Thr Pro Val Ala Met Ala Glu Gly Thr

50 55 60Arg Leu Lys Gln Pro Pro Ile Ile Val Pro Ile Ile Arg Ala Gly Leu 65 70 75 80Gly Met Ile Asp Pro Ala Leu Ser Met Ile Pro Asp Ala Gln Val Gly

85 90 95Phe Ile Gly Leu Ala Arg Asp Glu Glu Thr His Glu Pro Val Pro Tyr

100 105 110Leu Glu Ala Leu Pro Gln Asp Leu Ser Asn Gln Pro Val Phe Leu Val

115 120 125Asp Pro Met Leu Ala Thr Gly Gly Ser Leu Leu His Ala Ile Arg Leu

130 135 140Leu Ala Asp Arg Gly Ala Thr Asp Ile Thr Ala Ile Cys Met Val Ser145 150 155 160Ala Gln Pro Gly Val Asp Ala Leu Ala Glu Ser

165170<210>1019<211>678<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (655)<223>RXA02771<400>1019gtttgtgata gatcgcacag tcggtaacgt tgttgttaat acagacctag ccggtatcgg 60atggaacatg gaccgttggt ccagaagtga ggaataagta gtg agc gaa caa gct 115

Val Ser Glu Gln Ala

1 5cta agc acc ttc gac agg gca cgt gag gcc ctg gac aag aaa acc cga 163Leu Ser Thr Phe Asp Arg Ala Arg Glu Ala Leu Asp Lys Lys Thr Arg

10 15 20tat gtg cag gat ttc cca gaa aaa ggt gtg ctt ttt gaa gac ctc acc 211Tyr Val Gln Asp Phe Pro Glu Lys Gly Val Leu Phe Glu Asp Leu Thr

25 30 35ccg gtg ttg ggc gat gca gaa tca ttt gtg gcc gtg gtg gac gcc atg 259Pro Val Leu Gly Asp Ala Glu Ser Phe Val Ala Val Val Asp Ala Met

40 45 50gct gaa gct gca gaa aaa ctg aat gca gaa atc atc ggt ggc ttg gat 307Ala Glu Ala Ala Glu Lys Leu Asn Ala Glu Ile Ile Gly Gly Leu Asp

55 60 65gcg cga gga ttc ctc ctc gga tct gct gtc gct tac aaa ctc ggc cta 355Ala Arg Gly Phe Leu Leu Gly Ser Ala Val Ala Tyr Lys Leu Gly Leu 70 75 80 85ggt gtg ctg gct atc cgc aag aag gga aag ctc ccc cca cct gtg gtg 403Gly Val Leu Ala Ile Arg Lys Lys Gly Lys Leu Pro Pro Pro Val Val

90 95 100acc cag gag tat gaa ctt gaa tac ggc act gca gca ctc gag ctg ccc 451Thr Gln Glu Tyr Glu Leu Glu Tyr Gly Thr Ala Ala Leu Glu Leu Pro

105 110 115agt gaa gga atc gac att gct ggt aaa aac atc gtt ttg atc gac gat 499Ser Glu Gly Ile Asp Ile Ala Gly Lys Asn Ile Val Leu Ile Asp Asp

120 125 130gtg ctg gca acc ggc ggc acc ttg ggc gct gca cgt aaa cta att gaa 547Val Leu Ala Thr Gly Gly Thr Leu Gly Ala Ala Arg Lys Leu Ile Glu

135 140 145tcg tgt gac gga cat gtt tcc gga tat gtt ctt gcc att gag gtc cca 595Ser Cys Asp Gly His Val Ser Gly Tyr Val Leu Ala Ile Glu Val Pro150 155 160 165ggc ctc ggc ggt agg gat aat ctt ggt gat agg ccc gtc att gtg gtc 643Gly Leu Gly Gly Arg Asp Asn Leu Gly Asp Arg Pro Val Ile Val Val

170 175 180aga gat cct cag tagaaggatc gaaagaaagg cgg 678Arg Asp Pro Gln

185<210>1020<211>185<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1020Val Ser Glu Gln Ala Leu Ser Thr Phe Asp Arg Ala Arg Glu Ala Leu 151015 Asp Lys Lys Thr Arg Tyr Val Gln Asp Phe Pro Glu Lys Gly Val Leu

20 25 30Phe Glu Asp Leu Thr Pro Val Leu Gly Asp Ala Glu Ser Phe Val Ala

35 40 45Val Val Asp Ala Met Ala Glu Ala Ala Glu Lys Leu Asn Ala Glu Ile

50 55 60Ile Gly Gly Leu Asp Ala Arg Gly Phe Leu Leu Gly Ser Ala Val Ala 65 70 75 80Tyr Lys Leu Gly Leu Gly Val Leu Ala Ile Arg Lys Lys Gly Lys Leu

85 90 95Pro Pro Pro Val Val Thr Gln Glu Tyr Glu Leu Glu Tyr Gly Thr Ala

100 105 110Ala Leu Glu Leu Pro Ser Glu Gly Ile Asp Ile Ala Gly Lys Asn Ile

115 120 125Val Leu Ile Asp Asp Val Leu Ala Thr Gly Gly Thr Leu Gly Ala Ala

130 135 140Arg Lys Leu Ile Glu Ser Cys Asp Gly His Val Ser Gly Tyr Val Leu145 150155 160Ala Ile Glu Val Pro Gly Leu Gly Gly Arg Asp Asn Leu Gly Asp Arg

165 170 175Pro Val Ile Val Val Arg Asp Pro Gln

180185<210>1021<211>723<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (700)<223>RXA01512<400>1021gggtaaaagc gataatggaa ggttggaagt ggtgcggcaa agtggcaagc ttaagatcac 60tgattgacac ctgaatctac aacacaaggg gaacgcgacg atg agc aac aac gta 115

Met Ser Asn Asn Val

1 5gaa atg gcc gac cac aaa gat ctc aat gtt cca gcc aac cca tac ggc 163Glu Met Ala Asp His Lys Asp Leu Asn Val Pro Ala Asn Pro Tyr Gly

10 15 20acc gac att gaa tca gta ttg atc agc gaa gag aag ctc aag cag cgc 211Thr Asp Ile Glu Ser Val Leu Ile Ser Glu Glu Lys Leu Lys Gln Arg

25 30 35atc gcc gaa atg gcc aag cgc gtc tcc gaa gag ttc aaa gac gcc gaa 259Ile Ala Glu Met Ala Lys Arg Val Ser Glu Glu Phe Lys Asp Ala Glu

40 45 50gaa gac ctc atc ctg gtg tgc gtg ctc aag ggc gcg ttc tac ttc ctg 307Glu Asp Leu Ile Leu Val Cys Val Leu Lys Gly Ala Phe Tyr Phe Leu

55 60 65gca gat ttc tcc cgc atg ctc gac atc ccc acc cag tcc gag ttc atg 355Ala Asp Phe Ser Arg Met Leu Asp Ile Pro Thr Gln Ser Glu Phe Met 70 75 80 85gcg gtg tcc tct tac gga aac tcc acc tcc tct tca ggc gtg gtg cgc 403Ala Val Ser Ser Tyr Gly Asn Ser Thr Ser Ser Ser Gly Val ValArg

90 95 100atc ctc aag gac ctg gac aag gaa att gaa ggc cgc gac gtt ttg atc 451Ile Leu Lys Asp Leu Asp Lys Glu Ile Glu Gly Arg Asp Val Leu Ile

105 110 115gtg gaa gac atc atc gat tcc gga ctg acc ctg tcc tgg ctg atg cgc 499Val Glu Asp Ile Ile Asp Ser Gly Leu Thr Leu Ser Trp Leu Met Arg

120 125 130aac ctg aaa aac cgc aac cct aag tcc ctc aac gtg atc acc ttg ctg 547Asn Leu Lys Asn Arg Asn Pro Lys Ser Leu Asn Val Ile Thr Leu Leu

135 140 145cgt aag cca gag cgc ctg acc acc aac atc gac atg ttc gac att gga 595Arg Lys Pro Glu Arg Leu Thr Thr Asn Ile Asp Met Phe Asp Ile Gly150 155 160 165ttt gat att cca aat gag ttt gtt gtg ggc tac gga ctt gat ttc gca 643Phe Asp Ile Pro Asn Glu Phe Val Val Gly Tyr Gly Leu Asp Phe Ala

170 175 180gaa cgc tac cgc gac ctg cca tat gtg ggc acc ctc gag cct cac gtg 691Glu Arg Tyr Arg Asp Leu Pro Tyr Val Gly Thr Leu Glu Pro His Val

185 190 195tac tcc gac tagtaatcaa aagtgcgaaa gag 723Tyr Ser Asp

200<210>1022<211>200<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1022Met Ser Asn Asn Val Glu Met Ala Asp His Lys Asp Leu Asn Val Pro 151015 Ala Asn Pro Tyr Gly Thr Asp Ile Glu Ser Val Leu Ile Ser Glu Glu

20 25 30Lys Leu Lys Gln Arg Ile Ala Glu Met Ala Lys Arg Val Ser Glu Glu

35 40 45Phe Lys Asp Ala Glu Glu Asp Leu Ile Leu Val Cys Val Leu Lys Gly

50 55 60Ala Phe Tyr Phe Leu Ala Asp Phe Ser Arg Met Leu Asp Ile Pro Thr 65 70 75 80Gln Ser Glu Phe Met Ala Val Ser Ser Tyr Gly Asn Ser Thr Ser Ser

85 90 95Ser Gly Val Val Arg Ile Leu Lys Asp Leu Asp Lys Glu Ile Glu Gly

100 105 110Arg Asp Val Leu Ile Val Glu Asp Ile Ile Asp Ser Gly Leu Thr Leu

115 120 125Ser Trp Leu Met Arg Asn Leu Lys Asn Arg Asn Pro Lys Ser Leu Asn

130 135 140Val Ile Thr Leu Leu Arg Lys Pro Glu Arg Leu Thr Thr Asn Ile Asp145 150 155 160Met Phe Asp Ile Gly Phe Asp Ile Pro Asn Glu Phe Val Val Gly Tyr

165 170 175Gly Leu Asp Phe Ala Glu Arg Tyr Arg Asp Leu Pro Tyr Val Gly Thr

180 185 190Leu Glu Pro His Val Tyr Ser Asp

195200<210>1023<211>597<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (574)<223>RXA02031<400>1023tgcttgggcg ttaacgattc tatatatact tccctagaaa tcaagtgagc attcatctca 60ttgcagaacg ttgaagcatc attgactagg atatgtagac atg aca gag gaa cgc 115

Met Thr Glu Glu Arg

1 5gag att ctg acc tat gag atg ttc gga aca gca atg cgg gag ctg gcc 163Glu Ile Leu Thr Tyr Glu Met Phe Gly Thr Ala Met Arg Glu Leu Ala

10 15 20caa gaa att att gat gac tac cag cca gat tgc gtg ctg tcc att gcg 211Gln Glu Ile Ile Asp Asp Tyr Gln Pro Asp Cys Val Leu Ser Ile Ala

25 30 35cgt ggt ggt ctt cta atc ggt ggc gca ctt ggt tat gcg ctg ggt atc 259Arg Gly Gly Leu Leu Ile Gly Gly Ala Leu Gly Tyr Ala Leu Gly Ile

40 45 50aag aat gta tcg gtg atc aat gtg gag ttc tac acc gat att gga gag 307Lys Asn Val Ser Val Ile Asn Val Glu Phe Tyr Thr Asp Ile Gly Glu

55 60 65cac ttg gag gag cca atg atg ctg cct cca act cca aaa gct gtt gat 355His Leu Glu Glu Pro Met Met Leu Pro Pro Thr Pro Lys Ala Val Asp 70 75 80 85ctc tcg gga atg cgt gtg ctc gtc gct gac gat gtc gcg gat acc gga 403Leu Ser Gly Met Arg Val Leu Val Ala Asp Asp Val Ala Asp Thr Gly

90 95 100aag act ctt gag ttg gtc agg gac ttc ctg ggt gac caa gtt gtc gaa 451Lys Thr Leu Glu Leu Val Arg Asp Phe Leu Gly Asp Gln Val Val Glu

105 110 115gtg cgc act gca gtg atc tat cac aag cca aac agt gtg ttt aag ccg 499Val Arg Thr Ala Val Ile Tyr His Lys Pro Asn Ser Val Phe Lys Pro

120 125 130gag tat gtg tgg cgt gag act gat aag tgg att aac ttc cca tgg tct 547Glu Tyr Val Trp Arg Glu Thr Asp Lys Trp Ile Asn Phe Pro Trp Ser

135140145 acc ctg cct cca gtg gag cct tct aag taatttttca cccgtgaaag 594Thr Leu Pro Pro Val Glu Pro Ser Lys 150155 tgc 597<210>1024<211>158<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1024Met Thr Glu Glu Arg Glu Ile Leu Thr Tyr Glu Met Phe Gly Thr Ala 151015 Met Arg Glu Leu Ala Gln Glu Ile Ile Asp Asp Tyr Gln Pro Asp Cys

20 25 30Val Leu Ser Ile Ala Arg Gly Gly Leu Leu Ile Gly Gly Ala Leu Gly

35 40 45Tyr Ala Leu Gly Ile Lys Asn Val Ser Val Ile Asn Val Glu Phe Tyr

50 55 60Thr Asp Ile Gly Glu His Leu Glu Glu Pro Met Met Leu Pro Pro Thr 65 70 75 80Pro Lys Ala Val Asp Leu Ser Gly Met Arg Val Leu Val Ala Asp Asp

85 90 95Val Ala Asp Thr Gly Lys Thr Leu Glu Leu Val Arg Asp Phe Leu Gly

100 105 110Asp Gln Val Val Glu Val Arg Thr Ala Val Ile Tyr His Lys Pro Asn

115 120 125Ser Val Phe Lys Pro Glu Tyr Val Trp Arg Glu Thr Asp Lys Trp Ile

130135140 Asn Phe Pro Trp Ser Thr Leu Pro Pro Val Glu Pro Ser Lys 145150155<210>1025<211>753<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (730)<223>RXA00981<400>1025aaccaatggc tgggtactga tgtggtgatc agtgcccagt ttcttctttc tactagtgtc 60ggatagaagt acccccagtc cagaatgaag gtcaccacca atg tca gag aat ttg 115

Met Ser Glu Asn Leu

1 5cca gcg ccc gag aat ctc ctg gac gcc gag aga att cag atg atc aag 163Pro Ala Pro Glu Asn Leu Leu Asp Ala Glu Arg Ile Gln Met Ile Lys

10 1520aac ttc cgc aac gaa tta acg ggg ttc atg ctc aac tac caa ttt ggc 211Asn Phe Arg Asn Glu Leu Thr Gly Phe Met Leu Asn Tyr Gln Phe Gly

25 30 35att gat gag atc ctg acc aag atc aac atc ctg aaa act gaa ttc agc 259Ile Asp Glu Ile Leu Thr Lys Ile Asn Ile Leu Lys Thr Glu Phe Ser

40 45 50cag ctg cac gaa tac gca cct atc gag cac gta tct tca cga ttg aag 307Gln Leu His Glu Tyr Ala Pro Ile Glu His Val Ser Ser Arg Leu Lys

55 60 65aca cca gaa agc atc gtc aaa aag gtc atc cga aaa gga gac gag ctc 355Thr Pro Glu Ser Ile Val Lys Lys Val Ile Arg Lys Gly Asp Glu Leu 70 75 80 85tcc ctc gca gct atc aaa gac aca gtg ttt gat atc gca ggc att cga 403Ser Leu Ala Ala Ile Lys Asp Thr Val Phe Asp Ile Ala Gly Ile Arg

90 95 100atc gtc tgc agt ttc ctc aaa gat gcc tac gca atc gcc gat atg ctg 451Ile Val Cys Ser Phe Leu Lys Asp Ala Tyr Ala Ile Ala Asp Met Leu

105 110 115acc aac caa aaa gac gtc acg gtc atc gag gcc aaa gac tac atc gct 499Thr Asn Gln Lys Asp Val Thr Val Ile Glu Ala Lys Asp Tyr Ile Ala

120 125 130aac cca aag ccg aac ggc tac aag agt ttg cac ctt atc ctc caa gtg 547Asn Pro Lys Pro Asn Gly Tyr Lys Ser Leu His Leu Ile Leu Gln Val

135 140 145cct gtc ttc ctg tct aac tcc gtg gaa aag gtc aat gtt gaa gtc cag 595Pro Val Phe Leu Ser Asn Ser Val Glu Lys Val Asn Val Glu Val Gln150 155 160 165atc cgc acc att gcc atg gac ttc tgg gca agc ctc gag cac aaa atc 643Ile Arg Thr Ile AlaMet Asp Phe Trp Ala Ser Leu Glu His Lys Ile

170 175 180tac tac aaa ttt gaa caa gaa gtt cct cag tca atc ctt gat gag ctc 691Tyr Tyr Lys Phe Glu Gln Glu Val Pro Gln Ser Ile Leu Asp Glu Leu

185 190 195agt gaa gat gga aag aat cca cgg gga agt gaa gtc act taaacctcca 740Ser Glu Asp Gly Lys Asn Pro Arg Gly Ser Glu Val Thr

200205210 gttgaaacca ctg 753<210>1026<211>210<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1026Met Ser Glu Asn Leu Pro Ala Pro Glu Asn Leu Leu Asp Ala Glu Arg 151015 Ile Gln Met Ile Lys Asn Phe Arg Asn Glu Leu Thr Gly Phe Met Leu

20 25 30Asn Tyr Gln Phe Gly Ile Asp Glu Ile Leu Thr Lys Ile Asn Ile Leu

35 40 45Lys Thr Glu Phe Ser Gln Leu His Glu Tyr Ala Pro Ile Glu His Val

50 55 60Ser Ser Arg Leu Lys Thr Pro Glu Ser Ile Val Lys Lys Val Ile Arg 65 70 75 80Lys Gly Asp Glu Leu Ser Leu Ala Ala Ile Lys Asp Thr Val Phe Asp

85 90 95Ile Ala Gly Ile Arg Ile Val Cys Ser Phe Leu Lys Asp Ala Tyr Ala

100 105 110Ile Ala Asp Met Leu Thr Asn Gln Lys Asp Val Thr Val Ile Glu Ala

115 120 125Lys Asp Tyr Ile Ala Asn Pro Lys Pro Asn Gly Tyr Lys Ser Leu His

130 135 140Leu Ile Leu Gln Val Pro Val Phe Leu Ser Asn Ser Val Glu Lys Val145 150 155160Asn Val Glu Val Gln Ile Arg Thr Ile Ala Met Asp Phe Trp Ala Ser

165 170 175Leu Glu His Lys Ile Tyr Tyr Lys Phe Glu Gln Glu Val Pro Gln Ser

180 185 190Ile Leu Asp Glu Leu Ser Glu Asp Gly Lys Asn Pro Arg Gly Ser Glu

195 200 205Val Thr

210<210>1027<211>1158<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1135)<223>RXN02772<400>1027tgaggtccca ggcctcggcg gtagggataa tcttggtgat aggcccgtca ttgtggtcag 60agatcctcag tagaaggatc gaaagaaagg cggcaggaaa atg agt ctg gag cgc 115

Met Ser Leu Glu Arg

1 5aac aca caa aaa tct tcc atg ggt gtg cga agc atg tca gcc agg ctt 163Asn Thr Gln Lys Ser Ser Met Gly Val Arg Ser Met Ser Ala Arg Leu

10 15 20gcc cgc agc ctc aca gga aac cgc gtt cgc acc aac cct gtg ctg gat 211Ala Arg Ser Leu Thr Gly Asn Arg Val Arg Thr Asn Pro Val Leu Asp

25 30 35ccg ctg ctg agc atc cac cgg caa ttt cac cca cgc gcc gac gta caa 259Pro Leu Leu Ser Ile His Arg Gln Phe His Pro Arg Ala Asp Val Gln

40 45 50gtg ttg gaa cgt gca tat gac acc gcg gaa cgt ctt cat gat ggt gtg 307Val Leu Glu Arg Ala Tyr Asp Thr Ala Glu Arg Leu His Asp Gly Val

55 60 65att cga aaa tcg ggc gat ccg tat att acc cac ccg ttg gct gtc gcc 355Ile Arg Lys Ser Gly Asp ProTyr Ile Thr His Pro Leu Ala Val Ala 70 75 80 85acc atc gcc gcg gaa atc ggc atg gac acc acc acg ctc gtc gca gcc 403Thr Ile Ala Ala Glu Ile Gly Met Asp Thr Thr Thr Leu Val Ala Ala

90 95 100ttg ttg cat gac acg gtg gaa gac acc gac tac tct ttg gac gat ctc 451Leu Leu His Asp Thr Val Glu Asp Thr Asp Tyr Ser Leu Asp Asp Leu

105 110 115acc cga gat ttc gga gaa gaa gtt gcc agg ctt gtc gac ggt gtc acc 499Thr Arg Asp Phe Gly Glu Glu Val Ala Arg Leu Val Asp Gly Val Thr

120 125 130aag ctc gac aaa gtc gca cta ggt gct gcc gcg gag gcc gaa acg att 547Lys Leu Asp Lys Val Ala Leu Gly Ala Ala Ala Glu Ala Glu Thr Ile

135 140 145cgc aaa atg atc gtc gcc atg agc cag gac ccc cgc gtg ctg gtg att 595Arg Lys Met Ile Val Ala Met Ser Gln Asp Pro Arg Val Leu Val Ile150 155 160 165aaa gtg gcc gac cgt ttg cac aat atg cgc acc atg cgg ttc ctg ccg 643Lys Val Ala Asp Arg Leu His Asn Met Arg Thr Met Arg Phe Leu Pro

170 175 180ccg gaa aag caa gct aaa aaa gca cgc caa acc ctt gaa gtg att gct 691Pro Glu Lys Gln Ala Lys Lys Ala Arg Gln Thr Leu Glu Val Ile Ala

185 190 195cct ttg gca cac cgc ctg ggc atg gcc agc gtg aaa tgg gaa ttg gaa 739Pro Leu Ala His Arg Leu Gly Met Ala Ser Val Lys Trp Glu Leu Glu

200 205 210gat cta tcc ttt gcc att ttg tac ccc aag aag tac gaa gag atc gtg 787Asp Leu Ser Phe Ala Ile Leu Tyr Pro Lys Lys Tyr Glu Glu Ile Val

215220 225cgt ctt gtt gcc gac cgc gcg ccc tct aga gac cgg tac ctc aaa gaa 835Arg Leu Val Ala Asp Arg Ala Pro Ser Arg Asp Arg Tyr Leu Lys Glu230 235 240 245att att gat caa gtc acc ggt ggc ttg cgc gaa aac aac atc gcg gca 883Ile Ile Asp Gln Val Thr Gly Gly Leu Arg Glu Asn Asn Ile Ala Ala

250 255 260gaa gtg ctt ggt cga cca aag cac tac tgg tct atc tat caa aag atg 931Glu Val Leu Gly Arg Pro Lys His Tyr Trp Ser Ile Tyr Gln Lys Met

265 270 275atc gtt cgc ggt cgt gat ttt gac gat att ttt gat ctt gtt ggc atc 979Ile Val Arg Gly Arg Asp Phe Asp Asp Ile Phe Asp Leu Val Gly Ile

280 285 290cgc atc ctg gta gac aac gtg aac aac tgt gta cgc cgc cat cgg tgt 1027Arg Ile Leu Val Asp Asn Val Asn Asn Cys Val Arg Arg His Arg Cys

295 300 305cgt gca ctc cct gtt caa tgc tct gcc tgg ccg att caa aga cta tat 1075Arg Ala Leu Pro Val Gln Cys Ser Ala Trp Pro Ile Gln Arg Leu Tyr310 315 320 325ttc agc ccc gcg ctt cgg tgt cta cca atc cct gca cac cac cgt gat 1123Phe Ser Pro Ala Leu Arg Cys Leu Pro Ile Pro Ala His His Arg Asp

330 335 340ggg acc tgg cgg taagcctctg gaagttcagg cac 1158Gly Thr Trp Arg

345<210>1028<211>345<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1028Met Ser Leu Glu Arg Asn Thr Gln Lys Ser Ser Met Gly Val Arg Ser 151015 Met Ser Ala Arg Leu Ala Arg Ser Leu Thr Gly Asn Arg Val Arg Thr

20 25 30Asn Pro Val Leu Asp Pro LeuLeu Ser Ile His Arg Gln Phe His Pro

35 40 45Arg Ala Asp Val Gln Val Leu Glu Arg Ala Tyr Asp Thr Ala Glu Arg

50 55 60Leu His Asp Gly Val Ile Arg Lys Ser Gly Asp Pro Tyr Ile Thr His 65 70 75 80Pro Leu Ala Val Ala Thr Ile Ala Ala Glu Ile Gly Met Asp Thr Thr

85 90 95Thr Leu Val Ala Ala Leu Leu His Asp Thr Val Glu Asp Thr Asp Tyr

100 105 110Ser Leu Asp Asp Leu Thr Arg Asp Phe Gly Glu Glu Val Ala Arg Leu

115 120 125Val Asp Gly Val Thr Lys Leu Asp Lys Val Ala Leu Gly Ala Ala Ala

130 135 140Glu Ala Glu Thr Ile Arg Lys Met Ile Val Ala Met Ser Gln Asp Pro145 150 155 160Arg Val Leu Val Ile Lys Val Ala Asp Arg Leu His Asn Met Arg Thr

165 170 175Met Arg Phe Leu Pro Pro Glu Lys Gln Ala Lys Lys Ala Arg Gln Thr

180 185 190Leu Glu Val Ile Ala Pro Leu Ala His Arg Leu Gly Met Ala Ser Val

195 200 205Lys Trp Glu Leu Glu Asp Leu Ser Phe Ala Ile Leu Tyr Pro Lys Lys

210 215 220Tyr Glu Glu Ile Val Arg Leu Val Ala Asp Arg Ala Pro Ser Arg Asp225 230 235 240Arg Tyr Leu Lys Glu Ile Ile Asp Gln Val Thr Gly Gly Leu Arg Glu

245 250 255Asn Asn Ile Ala Ala GluVal Leu Gly Arg Pro Lys His Tyr Trp Ser

260 265 270Ile Tyr Gln Lys Met Ile Val Arg Gly Arg Asp Phe Asp Asp Ile Phe

275 280 285Asp Leu Val Gly Ile Arg Ile Leu Val Asp Asn Val Asn Asn Cys Val

290 295 300Arg Arg His Arg Cys Arg Ala Leu Pro Val Gln Cys Ser Ala Trp Pro305 310 315 320Ile Gln Arg Leu Tyr Phe Ser Pro Ala Leu Arg Cys Leu Pro Ile Pro

325 330 335Ala His His Arg Asp Gly Thr Trp Arg

340345<210>1029<211>903<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (880)<223>FRXA02772<220><221>misc _ failure<222>850, 853<223>n ═ a, c, t, or g<400>1029cattgtggtc agagatcctc agtagaagga tcgaaagaaa ggcggcagga aaatgagtct 60ggagcgcaac acacaaaaat cttccatggg tgtgcgaagc atg tca gcc agg ctt 115

Met Ser Ala Arg Leu

1 5gcc cgc agc ctc aca gga aac cgc gtt cgc acc aac cct gtg ctg gat 163Ala Arg Ser Leu Thr Gly Asn Arg Val Arg Thr Asn Pro Val Leu Asp

10 15 20ccg ctg ctg agc atc cac cgg caa ttt cac cca cgc gcc gac gta caa 211Pro Leu Leu Ser Ile His Arg Gln Phe His Pro Arg Ala Asp Val Gln

25 30 35gtg ttg gaa cgt gca tat gac acc gcg gaa cgt ctt cat gat ggt gtg 259Val Leu Glu Arg Ala Tyr Asp Thr Ala Glu Arg Leu His Asp Gly Val

40 45 50att cga aaa tcg ggc gat ccg tat att acc cac ccg ttg gct gtc gcc 307Ile Arg Lys Ser Gly Asp Pro Tyr Ile Thr His Pro Leu Ala Val Ala

55 60 65acc atc gcc gcg gaa atc ggc atg gac acc acc acg ctc gtc gca gcc 355Thr Ile Ala Ala Glu Ile Gly Met Asp Thr Thr Thr Leu Val Ala Ala 70 75 80 85ttg ttg cat gac acg gtg gaa gac acc gac tac tct ttg gac gat ctc 403Leu Leu His Asp Thr Val Glu Asp Thr Asp Tyr Ser Leu Asp Asp Leu

90 95 100acc cga gat ttc gga gaa gaa gtt gcc agg ctt gtc gac ggt gtc acc 451Thr Arg Asp Phe Gly Glu Glu Val Ala Arg Leu Val Asp Gly Val Thr

105 110 115aag ctc gac aaa gtc gca cta ggt gct gcc gcg gag gcc gaa acg att 499Lys Leu Asp Lys Val Ala Leu Gly Ala Ala Ala Glu Ala Glu Thr Ile

120 125 130cgc aaa atg atc gtc gcc atg agc cag gac ccc cgc gtg ctg gtg att 547Arg Lys Met Ile Val Ala Met Ser Gln Asp Pro Arg Val Leu Val Ile

135 140 145aaa gtg gcc gac cgt ttg cac aat atg cgc acc atg cgg ttc ctg ccg 595Lys Val Ala Asp Arg Leu His Asn Met Arg Thr Met Arg Phe Leu Pro150 155 160 165ccg gaa aag caa gct aaa aaa gca cgc caa acc ctt gaa gtg att gct 643Pro Glu Lys Gln Ala Lys Lys Ala Arg Gln Thr Leu Glu Val Ile Ala

170 175 180cct ttg gca cac cgc ctg ggc atg gcc agc gtg aaa tgg gaa ttg gaa 691Pro Leu Ala His Arg Leu Gly Met Ala Ser Val Lys Trp Glu Leu Glu

185 190 195gat cta tcc ttt gcc att ttg tac ccc aag aag tac gaa gag atc gtg 739Asp Leu Ser Phe Ala Ile Leu Tyr Pro Lys Lys Tyr Glu Glu Ile Val

200 205 210cgt ctt gtt gcc gac cgc gcg ccc tct aga gac cgg tac ctc aaa gaa 787Arg Leu Val Ala Asp Arg Ala Pro Ser Arg Asp Arg Tyr Leu Lys Glu

215 220 225att att gat caa gtc acc ggt ggc ttg cgc gaa aac aac atc gcg gca 835Ile Ile Asp Gln Val Thr Gly Gly Leu Arg Glu Asn Asn Ile Ala Ala230 235 240 245gaa gtg ctt ggt cgn ccn aag cac tct ggt ctt tct ttc aaa aga 880Glu Val Leu Gly Arg Pro Lys His Ser Gly Leu Ser Phe Lys Arg

250255260 tgatcgttcg cggtcgtgat ttt 903<210>1030<211>260<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1030Met Ser Ala Arg Leu Ala Arg Ser Leu Thr Gly Asn Arg Val Arg Thr 151015 Asn Pro Val Leu Asp Pro Leu Leu Ser Ile His Arg Gln Phe His Pro

20 25 30Arg Ala Asp Val Gln Val Leu Glu Arg Ala Tyr Asp Thr Ala Glu Arg

35 40 45Leu His Asp Gly Val Ile Arg Lys Ser Gly Asp Pro Tyr Ile Thr His

50 55 60Pro Leu Ala Val Ala Thr Ile Ala Ala Glu Ile Gly Met Asp Thr Thr 65 70 75 80Thr Leu Val Ala Ala Leu Leu His Asp Thr Val Glu Asp Thr Asp Tyr

85 90 95Ser Leu Asp Asp Leu Thr Arg Asp Phe Gly Glu Glu Val Ala Arg Leu

100 105 110Val Asp Gly Val Thr Lys Leu Asp Lys Val Ala Leu Gly Ala Ala Ala

115 120 125Glu Ala Glu Thr IleArg Lys Met Ile Val Ala Met Ser Gln Asp Pro

130 135 140Arg Val Leu Val Ile Lys Val Ala Asp Arg Leu His Asn Met Arg Thr145 150 155 160Met Arg Phe Leu Pro Pro Glu Lys Gln Ala Lys Lys Ala Arg Gln Thr

165 170 175Leu Glu Val Ile Ala Pro Leu Ala His Arg Leu Gly Met Ala Ser Val

180 185 190Lys Trp Glu Leu Glu Asp Leu Ser Phe Ala Ile Leu Tyr Pro Lys Lys

195 200 205Tyr Glu Glu Ile Val Arg Leu Val Ala Asp Arg Ala Pro Ser Arg Asp

210 215 220Arg Tyr Leu Lys Glu Ile Ile Asp Gln Val Thr Gly Gly Leu Arg Glu225 230 235 240Asn Asn Ile Ala Ala Glu Val Leu Gly Arg Pro Lys His Ser Gly Leu

245 250 255Ser Phe Lys Arg

260<210>1031<211>262<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (262)<223>FRXA02773<220><221>misc _ feature<222>7l, 74, 155, 162, 192, 214, 225, 230, 233<223>n ═ a, c, t, or g<220><221>VARIANT<222>19<223>Xaa ═ Phe, Leu, Ile, or Val<220><221>VARIANT<222>21<223>Xaa ═ Val, Ala, Glu, or Gly<220><221>VARIANT<222>31<223>Xaa ═ Leu, Pro, His, or Arg<220><221>VARIANT<222>42<223>Xaa ═ Val, Ala, Asp, or Gly<220><221>VARIANT<222>44<223>Xaa ═ Ser, Pro, Thr, or Ala<220>-VARIRIRIRIR<222>45<223>Phe, Leu, 221>VARIE, or Val<400>1031tcaaagaaat tattgatcaa gtcaccggtg gcttgcgcga aaacaacatc gcggcagaag 60tgcttggtcg nccnaagcac tctggtcttt ctttcaaaag atg atc gtt cgc ggt 115.

Met Ile Val Arg Gly

1 5cgt gat ttt gac gat att ttt gat ctt gtt ggc atc cgc ntc ctg gna 163Arg Asp Phe Asp Asp Ile Phe Asp Leu Val Gly Ile Arg Xaa Leu Xaa

10 15 20gac aac gtg aac aac tgg gta cgc cgc cnt cgg tgt cgt gca ctc ccn 211Asp Asn Val Asn Asn Trp Val Arg Arg Xaa Arg Cys Arg Ala Leu Pro

25 30 35gtn caa tgc tct gnc tgg ncg ntt caa aga cta tat ttc agc ccc gcg 259Val Gln Cys Ser Xaa Trp Xaa Xaa Gln Arg Leu Tyr Phe Ser Pro Ala

404550 ctt 262Leu<210>1032<211>54<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>VARIANT<222>19<223>Xaa ═ Phe, Leu, Ile, or Val<220><221>VARIANT<222>21<223>Xaa ═ Val, Ala, Glu, or Gly<220><221>VARIANT<222>31<223>Xaa ═ Leu, Pro, His, or<Arg 220><221>VARIANT<222>42<223>Xaa ═ Val, Ala, Asp, or Gly<220><221>VARIANT<222>44<223>Xaa ═ Ser, Pro, Thr, or Ala<220>VARIANT<222>45<223>Phe<200>Phe, Leu<1032>3652>Val<52>220>Val<46<45<46>Phe<46>Xaa ═ Phe, Leu<400>36015>Val<32>3652>Leu<52>Leu<35>3652>Xaa

20 25 30Cys Arg Ala Leu Pro Val Gln Cys Ser Xaa Trp Xaa Xaa Gln Arg Leu

35 40 45Tyr Phe Ser Pro Ala Leu

50<210>1033<211>654<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (631)<223>RXA01835<400>1033tcaacatcta ttcctcctgc gatttgcatg ggatatatat taaaaattct agccgaaagt 60ttcctgcgtg aatacacttt ccccgcgcct tcgcaaagct atg aat act gcc gcg 115

Met Asn Thr Ala Ala

1 5tgg gca cac cgc cac cac gta cgc aaa ggc ggt gga att ccg tat gtc 163Trp Ala His Arg His His Val Arg Lys Gly Gly Gly Ile Pro Tyr Val

10 15 20agc cat ctt tat tca gtg atg tac ttg ctg gcc agc gtc act aat gat 211Ser His Leu Tyr Ser Val Met Tyr Leu Leu Ala Ser Val Thr Asn Asp

25 30 35gaa gat gtg ctc atc gcc ggg ctg ctc cac gac acc ctc gaa gac gta 259Glu Asp Val Leu Ile Ala Gly Leu Leu His Asp Thr Leu Glu Asp Val

40 45 50ccc gag gaa tac aat tct gcc caa ctt gaa gct gat ttt ggt ccg cgg 307Pro Glu Glu Tyr Asn Ser Ala Gln Leu Glu Ala Asp Phe Gly Pro Arg

55 60 65gtg cgc gag ttg gtg gaa gag ctc acc aaa cag ccc tta aaa agc tgg 355Val Arg Glu Leu Val Glu Glu Leu Thr Lys Gln Pro Leu Lys Ser Trp 70 75 80 85aaa gcg cgt gcc gac gct tac ctc ctg cac ctc agc gca ggt gcc agc 403Lys Ala Arg Ala Asp Ala Tyr Leu Leu His Leu Ser Ala Gly Ala Ser

90 95 100tta gag gct gtc tta atc tcc acc gca gat aaa ctg cat aat ctc atg 451Leu GluAla Val Leu Ile Ser Thr Ala Asp Lys Leu His Asn Leu Met

105 110 115tcc atc ttg gat gac ctt gaa ata cac ggt gaa gat tta tgg caa cgc 499Ser Ile Leu Asp Asp Leu Glu Ile His Gly Glu Asp Leu Trp Gln Arg

120 125 130ttt aac gct ggc aaa gag cag caa atc tgg tgg tat agc gag gtt tat 547Phe Asn Ala Gly Lys Glu Gln Gln Ile Trp Trp Tyr Ser Glu Val Tyr

135 140 145cag ata tct ctc cag cgc tta ggg ttc aat gag ttg aat aaa caa ctg 595Gln Ile Ser Leu Gln Arg Leu Gly Phe Asn Glu Leu Asn Lys Gln Leu150 155 160 165ggg ttg tgc gtc gaa aag ctc tta aag caa agc gcc taggcgctcg 641Gly Leu Cys Val Glu Lys Leu Leu Lys Gln Ser Ala

170175 gcggcgtcga taa 654<210>1034<211>177<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1034Met Asn Thr Ala Ala Trp Ala His Arg His His Val Arg Lys Gly Gly 151015 Gly Ile Pro Tyr Val Ser His Leu Tyr Ser Val Met Tyr Leu Leu Ala

20 25 30Ser Val Thr Asn Asp Glu Asp Val Leu Ile Ala Gly Leu Leu His Asp

35 40 45Thr Leu Glu Asp Val Pro Glu Glu Tyr Asn Ser Ala Gln Leu Glu Ala

50 55 60Asp Phe Gly Pro Arg Val Arg Glu Leu Val Glu Glu Leu Thr Lys Gln 65 70 75 80Pro Leu Lys Ser Trp Lys Ala Arg Ala Asp Ala Tyr Leu Leu His Leu

85 90 95Ser Ala Gly Ala Ser Leu Glu Ala Val Leu Ile Ser Thr Ala Asp Lys

100 105110Leu His Asn Leu Met Ser Ile Leu Asp Asp Leu Glu Ile His Gly Glu

115 120 125Asp Leu Trp Gln Arg Phe Asn Ala Gly Lys Glu Gln Gln Ile Trp Trp

130 135 140Tyr Ser Glu Val Tyr Gln Ile Ser Leu Gln Arg Leu Gly Phe Asn Glu145 150 155 160Leu Asn Lys Gln Leu Gly Leu Cys Val Glu Lys Leu Leu Lys Gln Ser

165170175 Ala<210>1035<211>1395<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220>CDS<222>(101) }, (1372)<223>RXA01483<400>1035gggtgcccga taaggtgaag catctttgcg cgcaatccaa ggtctgctgc gcccttcgcg 60gcgtgcacgc catgagcaac ttcggaggct gaaaaagtag atg tac ccc tat tcc 115

Met Tyr Pro Tyr Ser

1 5gac gca gac gct ttt cga cgc cag cct gag cgc gcc aag tcc agc caa 163Asp Ala Asp Ala Phe Arg Arg Gln Pro Glu Arg Ala Lys Ser Ser Gln

10 15 20ctg cgt acc agc gcc gta gac acc cgc agc gcg ttc gcc cgc gac cgg 211Leu Arg Thr Ser Ala Val Asp Thr Arg Ser Ala Phe Ala Arg Asp Arg

25 30 35gct cgc gtg ctg cat tct gct gct ctt cga cgc ctc gcg gat aaa acc 259Ala Arg Val Leu His Ser Ala Ala Leu Arg Arg Leu Ala Asp Lys Thr

40 45 50caa gtg gtt ggc ccc aat gat ggt gat act ccg cgc acc cgg ctg acg 307Gln Val Val Gly Pro Asn Asp Gly Asp Thr Pro Arg Thr Arg Leu Thr

55 60 65cac tct ttg gaa gta gct caa att gca cgg gga atc gga gct gga ctg 355His Ser Leu Glu Val Ala Gln Ile Ala Arg Gly Ile Gly Ala Gly Leu 70 75 80 85gat ttg gat cct gat ctg tgc gat ctg gca ggg ctg tgc cat gac att 403Asp Leu Asp Pro Asp Leu Cys Asp Leu Ala Gly Leu Cys His Asp Ile

90 95 100ggg cat ccg ccg tat gga cac aac ggt gaa aac gcg ttg aat gaa gtt 451Gly His Pro Pro Tyr Gly His Asn Gly Glu Asn Ala Leu Asn Glu Val

105 110 115gct gcg gcc tgt gga gga ttt gag ggc aac gcc caa acc ttg cgt att 499Ala Ala Ala Cys Gly Gly Phe Glu Gly Asn Ala Gln Thr Leu Arg Ile

120 125 130ctc acg cgt ctg gag cca aaa att gtc tct gat gag ggg gag agc ttt 547Leu Thr Arg Leu Glu Pro Lys Ile Val Ser Asp Glu Gly Glu Ser Phe

135 140 145ggg ctg aac ttg tcg cgg gct gct ctt gat gct gca tgt aag tat ccg 595Gly Leu Asn Leu Ser Arg Ala Ala Leu Asp Ala Ala Cys Lys Tyr Pro150 155 160 165tgg gct aaa aca aat gcg gat ggc agt gtc aat aag aaa tac agt gct 643Trp Ala Lys Thr Asn Ala Asp Gly Ser Val Asn Lys Lys Tyr Ser Ala

170 175 180tat gac gag gac gca gaa atc ctc gct tgg att aga caa ggc cat gag 691Tyr Asp Glu Asp Ala Glu Ile Leu Ala Trp Ile Arg Gln Gly His Glu

185 190 195gat ctt cgc cca ccg atc gaa gcg cag gtc atg gac ttt tct gat gac 739Asp Leu Arg Pro Pro Ile Glu Ala Gln Val Met Asp Phe Ser Asp Asp

200 205 210att gcc tac tcg gtg cac gat gtg gaa gac ggt att gta tcc ggg cgt 787Ile Ala Tyr Ser Val His Asp Val Glu Asp Gly Ile Val Ser Gly Arg

215220 225atc gac tta aaa gtg ctg tgg gac ctg gtt gaa tta gca gct ttg gca 835Ile Asp Leu Lys Val Leu Trp Asp Leu Val Glu Leu Ala Ala Leu Ala230 235 240 245gac aaa gga gca gct gct ttc gga ggt tcg cct gca gag ctc atc gag 883Asp Lys Gly Ala Ala Ala Phe Gly Gly Ser Pro Ala Glu Leu Ile Glu

250 255 260ggt gca gca tcg ttg cgg gaa ctt ccg gtg gtg gct gcc gct gcg gat 931Gly Ala Ala Ser Leu Arg Glu Leu Pro Val Val Ala Ala Ala Ala Asp

265 270 275ttt gat ttc tca ctg cgt tcc tac gct gcg ctg aag gcg atg act tca 979Phe Asp Phe Ser Leu Arg Ser Tyr Ala Ala Leu Lys Ala Met Thr Ser

280 285 290gaa cta gtg gga aga tac gtt ggc tct acc atc gag tca aca aag aaa 1027Glu Leu Val Gly Arg Tyr Val Gly Ser Thr Ile Glu Ser Thr Lys Lys

295 300 305aca cac gct ggc att gat gtg gga cgc atg cac ggc gat ttg atc att 1075Thr His Ala Gly Ile Asp Val Gly Arg Met His Gly Asp Leu Ile Ile310 315 320 325cca gaa aca gcg gcc agt gaa gta aaa ctg ctc aaa acg tta gcg gtt 1123Pro Glu Thr Ala Ala Ser Glu Val Lys Leu Leu Lys Thr Leu Ala Val

330 335 340ctc tac gtg atg gat gac cca ggg cac ctt gcg cgc caa aac agg caa 1171Leu Tyr Val Met Asp Asp Pro Gly His Leu Ala Arg Gln Asn Arg Gln

345 350 355cgg gat cgt atc ttc cgg gtt ttt gac tac ctg gtg ctg ggg gct ccg 1219Arg Asp Arg Ile Phe Arg Val Phe Asp Tyr Leu Val Leu Gly Ala Pro

360 365 370gga tcg ttg gat ccg atg tat cgc cag tgg ttt att gaa gcggat tca 1267Gly Ser Leu Asp Pro Met Tyr Arg Gln Trp Phe Ile Glu Ala Asp Ser

375 380 385gaa tcg gaa cag atc cgt gtg att gtt gat cag att gcg tcg atg acg 1315Glu Ser Glu Gln Ile Arg Val Ile Val Asp Gln Ile Ala Ser Met Thr390 395 400 405gag tct cgt ctg gaa cgc ctt gcc cgg aat gct gct gac atc tca gga 1363Glu Ser Arg Leu Glu Arg Leu Ala Arg Asn Ala Ala Asp Ile Ser Gly

410415420 ttt ttg gga taattggtta gagcagcagt aag 1395Phe Leu Gly<210>1036<211>424<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1036Met Tyr Pro Tyr Ser Asp Ala Asp Ala Phe Arg Arg Gln Pro Glu Arg 151015 Ala Lys Ser Ser Gln Leu Arg Thr Ser Ala Val Asp Thr Arg Ser Ala

20 25 30Phe Ala Arg Asp Arg Ala Arg Val Leu His Ser Ala Ala Leu Arg Arg

35 40 45Leu Ala Asp Lys Thr Gln Val Val Gly Pro Asn Asp Gly Asp Thr Pro

50 55 60Arg Thr Arg Leu Thr His Ser Leu Glu Val Ala Gln Ile Ala Arg Gly 65 70 75 80Ile Gly Ala Gly Leu Asp Leu Asp Pro Asp Leu Cys Asp Leu Ala Gly

85 90 95Leu Cys His Asp Ile Gly His Pro Pro Tyr Gly His Asn Gly Glu Asn

100 105 110Ala Leu Asn Glu Val Ala Ala Ala Cys Gly Gly Phe Glu Gly Asn Ala

115 120 125Gln Thr Leu Arg Ile Leu Thr Arg Leu Glu Pro Lys Ile Val Ser Asp

130 135 140Glu Gly Glu Ser Phe Gly Leu Asn Leu Ser Arg Ala Ala Leu Asp Ala145 150 155 160Ala Cys Lys Tyr Pro Trp Ala Lys Thr Asn Ala Asp Gly Ser Val Asn

165 170 175Lys Lys Tyr Ser Ala Tyr Asp Glu Asp Ala Glu Ile Leu Ala Trp Ile

180 185 190Arg Gln Gly His Glu Asp Leu Arg Pro Pro Ile Glu Ala Gln Val Met

195 200 205Asp Phe Ser Asp Asp Ile Ala Tyr Ser Val His Asp Val Glu Asp Gly

210 215 220Ile Val Ser Gly Arg Ile Asp Leu Lys Val Leu Trp Asp Leu Val Glu225 230 235 240Leu Ala Ala Leu Ala Asp Lys Gly Ala Ala Ala Phe Gly Gly Ser Pro

245 250 255Ala Glu Leu Ile Glu Gly Ala Ala Ser Leu Arg Glu Leu Pro Val Val

260 265 270Ala Ala Ala Ala Asp Phe Asp Phe Ser Leu Arg Ser Tyr Ala Ala Leu

275 280 285Lys Ala Met Thr Ser Glu Leu Val Gly Arg Tyr Val Gly Ser Thr Ile

290 295 300Glu Ser Thr Lys Lys Thr His Ala Gly Ile Asp Val Gly Arg Met His305 310 315 320Gly Asp Leu Ile Ile Pro Glu Thr Ala Ala Ser Glu Val Lys Leu Leu

325 330 335Lys Thr Leu Ala Val Leu Tyr Val Met Asp Asp Pro Gly His Leu Ala

340 345 350Arg Gln Asn Arg Gln Arg Asp Arg Ile Phe Arg Val Phe Asp Tyr Leu

355 360 365Val Leu Gly Ala Pro Gly Ser Leu Asp Pro Met Tyr ArgGln Trp Phe

370 375 380Ile Glu Ala Asp Ser Glu Ser Glu Gln Ile Arg Val Ile Val Asp Gln385 390 395 400Ile Ala Ser Met Thr Glu Ser Arg Leu Glu Arg Leu Ala Arg Asn Ala

405 410 415Ala Asp Ile Ser Gly Phe Leu Gly

420<210>1037<211>1131<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1108)<223>RXN01027<400>1037aatagatgga agtagttttt cattcactta tgtgcgcgtt tttaatctgg tttctaccaa 60gaactgtgtg caccacaacg cggaaggtga atcgcaccca atg gca aat aag aac 115

Met Ala Asn Lys Asn

1 5aat aag cct cat gag gtg gac aaa gac caa gat tca gcc atg ctg atc 163Asn Lys Pro His Glu Val Asp Lys Asp Gln Asp Ser Ala Met Leu Ile

10 15 20aac ggt cgc ctg caa cag atc ccg gcg cgt ccc act gag gaa ttc acc 211Asn Gly Arg Leu Gln Gln Ile Pro Ala Arg Pro Thr Glu Glu Phe Thr

25 30 35cgc cca act ctt gca gca ggt gca gta ctg tgg cgc ggc gac atc acc 259Arg Pro Thr Leu Ala Ala Gly Ala Val Leu Trp Arg Gly Asp Ile Thr

40 45 50aac ccg gac agc atc gag gtc gct gtc atc cac cgc ccg cac tat gat 307Asn Pro Asp Ser Ile Glu Val Ala Val Ile His Arg Pro His Tyr Asp

55 60 65gac tgg tcc ctg gcc aag ggc aaa gtc gat ccc ggc gag tct att ccg 355Asp Trp Ser Leu Ala Lys Gly Lys Val Asp Pro Gly Glu Ser Ile Pro 70 7580 85aca acc gcg gcc cgt gaa atc ctt gaa gaa act ggc tac gac atc cgt 403Thr Thr Ala Ala Arg Glu Ile Leu Glu Glu Thr Gly Tyr Asp Ile Arg

90 95 100ctg ggc aag ctg atc ggc aag gtt act tac cct gtg ctc gac cga acc 451Leu Gly Lys Leu Ile Gly Lys Val Thr Tyr Pro Val Leu Asp Arg Thr

105 110 115aaa gtg gtc tac tac tgg act gcc cag gtt ctt ggt gga gag ttt gtc 499Lys Val Val Tyr Tyr Trp Thr Ala Gln Val Leu Gly Gly Glu Phe Val

120 125 130ccc aac gat gaa gtt gat gaa atc cgt tgg ctg tct gtt gat gaa gca 547Pro Asn Asp Glu Val Asp Glu Ile Arg Trp Leu Ser Val Asp Glu Ala

135 140 145tgc gag ttg ctc agc tac caa gta gat acc gaa gtt ctg gcc aag gca 595Cys Glu Leu Leu Ser Tyr Gln Val Asp Thr Glu Val Leu Ala Lys Ala150 155 160 165gca aag cgt ttc cgc act cct tcc acc act cgg gtg ctg tat gtt cgc 643Ala Lys Arg Phe Arg Thr Pro Ser Thr Thr Arg Val Leu Tyr Val Arg

170 175 180cat gct cat gca cat ggt cgc caa acc tgg ggt ggc gac gac aat aag 691His Ala His Ala His Gly Arg Gln Thr Trp Gly Gly Asp Asp Asn Lys

185 190 195cgc cca ttg gac aaa aag ggg cgt cga caa gca gaa atg ctc gta ccc 739Arg Pro Leu Asp Lys Lys Gly Arg Arg Gln Ala Glu Met Leu Val Pro

200 205 210atg ttg ttg ccc ttc aaa ccc acc gca att tac tcg gcg gtg ccc gat 787Met Leu Leu Pro Phe Lys Pro Thr Ala Ile Tyr Ser Ala Val Pro Asp

215 220 225cgc tgc caa gcc acc gcg ctc ccc ctt gccgat gag ctc ggc ctc gac 835Arg Cys Gln Ala Thr Ala Leu Pro Leu Ala Asp Glu Leu Gly Leu Asp230 235 240 245gtg tcc gtc aac cga ctg ttc ggc gac gac gcc tgg gaa acc gat ccc 883Val Ser Val Asn Arg Leu Phe Gly Asp Asp Ala Trp Glu Thr Asp Pro

250 255 260gag gcc tgc aag aag cgc ttc acc gac gtg gtc gcg caa ggt ggc gtg 931Glu Ala Cys Lys Lys Arg Phe Thr Asp Val Val Ala Gln Gly Gly Val

265 270 275ccg atg atc gtt ggg cag ggc gac atc att ccg gaa atg atc aaa tgg 979Pro Met Ile Val Gly Gln Gly Asp Ile Ile Pro Glu Met Ile Lys Trp

280 285 290ttc tcc gag aac ggc acc ctc cct atc gat gag aag atc aag gcg aaa 1027Phe Ser Glu Asn Gly Thr Leu Pro Ile Asp Glu Lys Ile Lys Ala Lys

295 300 305aag ggc agc gtg tgg gtg ttg agc ttt cac gac ggt gtg ttc acc ggc 1075Lys Gly Ser Val Trp Val Leu Ser Phe His Asp Gly Val Phe Thr Gly310 315 320 325gct gat tac ctg gcg agt tcc ctg ccg gtt aaa taggagcgcg tttaaggcct 1128Ala Asp Tyr Leu Ala Ser Ser Leu Pro Val Lys

330335 cca 1131<210>1038<211>336<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1038Met Ala Asn Lys Asn Asn Lys Pro His Glu Val Asp Lys Asp Gln Asp 151015 Ser Ala Met Leu Ile Asn Gly Arg Leu Gln Gln Ile Pro Ala Arg Pro

20 25 30Thr Glu Glu Phe Thr Arg Pro Thr Leu Ala Ala Gly Ala Val Leu Trp

35 40 45Arg Gly Asp Ile Thr Asn Pro Asp Ser Ile Glu Val Ala Val Ile His

5055 60Arg Pro His Tyr Asp Asp Trp Ser Leu Ala Lys Gly Lys Val Asp Pro 65 70 75 80Gly Glu Ser Ile Pro Thr Thr Ala Ala Arg Glu Ile Leu Glu Glu Thr

85 90 95Gly Tyr Asp Ile Arg Leu Gly Lys Leu Ile Gly Lys Val Thr Tyr Pro

100 105 110Val Leu Asp Arg Thr Lys Val Val Tyr Tyr Trp Thr Ala Gln Val Leu

115 120 125Gly Gly Glu Phe Val Pro Asn Asp Glu Val Asp Glu Ile Arg Trp Leu

130 135 140Ser Val Asp Glu Ala Cys Glu Leu Leu Ser Tyr Gln Val Asp Thr Glu145 150 155 160Val Leu Ala Lys Ala Ala Lys Arg Phe Arg Thr Pro Ser Thr Thr Arg

165 170 175Val Leu Tyr Val Arg His Ala His Ala His Gly Arg Gln Thr Trp Gly

180 185 190Gly Asp Asp Asn Lys Arg Pro Leu Asp Lys Lys Gly Arg Arg Gln Ala

195 200 205Glu Met Leu Val Pro Met Leu Leu Pro Phe Lys Pro Thr Ala Ile Tyr

210 215 220Ser Ala Val Pro Asp Arg Cys Gln Ala Thr Ala Leu Pro Leu Ala Asp225 230 235 240Glu Leu Gly Leu Asp Val Ser Val Asn Arg Leu Phe Gly Asp Asp Ala

245 250 255Trp Glu Thr Asp Pro Glu Ala Cys Lys Lys Arg Phe Thr Asp Val Val

260 265 270Ala Gln Gly Gly Val Pro Met Ile Val Gly Gln Gly Asp Ile Ile Pro

275280 285Glu Met Ile Lys Trp Phe Ser Glu Asn Gly Thr Leu Pro Ile Asp Glu

290 295 300Lys Ile Lys Ala Lys Lys Gly Ser Val Trp Val Leu Ser Phe His Asp305 310 315 320Gly Val Phe Thr Gly Ala Asp Tyr Leu Ala Ser Ser Leu Pro Val Lys

325330335<210>1039<211>757<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (757)<223>FRXA01024<400>1039aatagatgga agtagttttt cattcactta tgtgcgcgtt tttaatctgg tttctaccaa 60gaactgtgtg caccacaacg cggaaggtga atcgcaccca atg gca aat aag aac 115

Met Ala Asn Lys Asn

1 5aat aag cct cat gag gtg gac aaa gac caa gat tca gcc atg ctg atc 163Asn Lys Pro His Glu Val Asp Lys Asp Gln Asp Ser Ala Met Leu Ile

10 15 20aac ggt cgc ctg caa cag atc ccg gcg cgt ccc act gag gaa ttc acc 211Asn Gly Arg Leu Gln Gln Ile Pro Ala Arg Pro Thr Glu Glu Phe Thr

25 30 35cgc cca act ctt gca gca ggt gca gta ctg tgg cgc ggc gac atc acc 259Arg Pro Thr Leu Ala Ala Gly Ala Val Leu Trp Arg Gly Asp Ile Thr

40 45 50aac ccg gac agc atc gag gtc gct gtc atc cac cgc ccg cac tat gat 307Asn Pro Asp Ser Ile Glu Val Ala Val Ile His Arg Pro His Tyr Asp

55 60 65gac tgg tcc ctg gcc aag ggc aaa gtc gat ccc ggc gag tct att ccg 355Asp Trp Ser Leu Ala Lys Gly Lys Val Asp Pro Gly Glu Ser Ile Pro 70 75 8085aca acc gcg gcc cgt gaa atc ctt gaa gaa act ggc tac gac atc cgt 403Thr Thr Ala Ala Arg Glu Ile Leu Glu Glu Thr Gly Tyr Asp Ile Arg

90 95 100ctg ggc aag ctg atc ggc aag gtt act tac cct gtg ctc gac cga acc 451Leu Gly Lys Leu Ile Gly Lys Val Thr Tyr Pro Val Leu Asp Arg Thr

105 110 115aaa gtg gtc tac tac tgg act gcc cag gtt ctt ggt gga gag ttt gtc 499Lys Val Val Tyr Tyr Trp Thr Ala Gln Val Leu Gly Gly Glu Phe Val

120 125 130ccc aac gat gaa gtt gat gaa atc cgt tgg ctg tct gtt gat gaa gca 547Pro Asn Asp Glu Val Asp Glu Ile Arg Trp Leu Ser Val Asp Glu Ala

135 140 145tgc gag ttg ctc agc tac caa gta gat acc gaa gtt ctg gcc aag gca 595Cys Glu Leu Leu Ser Tyr Gln Val Asp Thr Glu Val Leu Ala Lys Ala150 155 160 165gca aag cgt ttc cgc act cct tcc acc act cgg gtg ctg tat gtt cgc 643Ala Lys Arg Phe Arg Thr Pro Ser Thr Thr Arg Val Leu Tyr Val Arg

170 175 180cat gct cat gca cat ggt cgc caa acc tgg ggt ggc gac gac aat aag 691His Ala His Ala His Gly Arg Gln Thr Trp Gly Gly Asp Asp Asn Lys

185 190 195cgc cca ttg gac aaa aag ggg cgt cga caa gca gaa atg ctc gta ccc 739Arg Pro Leu Asp Lys Lys Gly Arg Arg Gln Ala Glu Met Leu Val Pro

200 205 210atg ttg ttg ccc ttc aaa 757Met Leu Leu Pro Phe Lys

215<210>1040<211>219<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1040Met Ala Asn Lys Asn Asn Lys Pro His Glu Val Asp Lys Asp Gln Asp 151015 Ser Ala Met Leu Ile Asn Gly Arg Leu Gln Gln Ile Pro Ala Arg Pro

20 25 30Thr Glu Glu Phe Thr Arg Pro Thr Leu Ala Ala Gly Ala Val Leu Trp

35 40 45Arg Gly Asp Ile Thr Asn Pro Asp Ser Ile Glu Val Ala Val Ile His

50 55 60Arg Pro His Tyr Asp Asp Trp Ser Leu Ala Lys Gly Lys Val Asp Pro 65 70 75 80Gly Glu Ser Ile Pro Thr Thr Ala Ala Arg Glu Ile Leu Glu Glu Thr

85 90 95Gly Tyr Asp Ile Arg Leu Gly Lys Leu Ile Gly Lys Val Thr Tyr Pro

100 105 110Val Leu Asp Arg Thr Lys Val Val Tyr Tyr Trp Thr Ala Gln Val Leu

115 120 125Gly Gly Glu Phe Val Pro Asn Asp Glu Val Asp Glu Ile Arg Trp Leu

130 135 140Ser Val Asp Glu Ala Cys Glu Leu Leu Ser Tyr Gln Val Asp Thr Glu145 150 155 160Val Leu Ala Lys Ala Ala Lys Arg Phe Arg Thr Pro Ser Thr Thr Arg

165 170 175Val Leu Tyr Val Arg His Ala His Ala His Gly Arg Gln Thr Trp Gly

180 185 190Gly Asp Asp Asn Lys Arg Pro Leu Asp Lys Lys Gly Arg Arg Gln Ala

195 200 205Glu Met Leu Val Pro Met Leu Leu Pro Phe Lys

210215<210>1041<211>257<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (234)<223>FRXA01027<400>1041acc gat ccc gag gcc tgc aag aag cgc ttc acc gac gtg gtc gcg caa 48 39151015 151015 ggt ggc gtg ccg atg atc gtt ggg cag ggc gac atc att ccg gaa atg 96Gly Gly Val Pro Met Ile Val Gly Gln Gly Asp Ile Ile Pro Glu Met<400>1041acc gat ccc gag gcc tgc aag aag cgc ttc acc gac gtg gtc gcg caa 48Thr Asp Pro Glu Ala Cys Lys Lys Arg Phe Thr Asp Val Val Ala Gln 151015 35015 ggt ggc gtg ccg atg atc gtt ggg cag ggc gac atc att ccg gaa atg

20 25 30atc aaa tgg ttc tcc gag aac ggc acc ctc cct atc gat gag aag atc 144Ile Lys Trp Phe Ser Glu Asn Gly Thr Leu Pro Ile Asp Glu Lys Ile

35 40 45aag gcg aaa aag ggc agc gtg tgg gtg ttg agc ttt cac gac ggt gtg 192Lys Ala Lys Lys Gly Ser Val Trp Val Leu Ser Phe His Asp Gly Val

505560 ttc acc ggc gct gat tac ctg gcg agt tcc ctg ccg gtt aaa 234Phe Thr Gly Ala Asp Tyr Leu Ala Ser Ser Leu Pro Val Lys 657075 taggagcgcg tttaaggcct cca 257<210>1042<211>78<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1042Thr Asp Pro Glu Ala Cys Lys Lys Arg Phe Thr Asp Val Val Ala Gln 151015 Gly Gly Val Pro Met Ile Val Gly Gln Gly Asp Ile Ile Pro Glu Met

20 25 30Ile Lys Trp Phe Ser Glu Asn Gly Thr Leu Pro Ile Asp Glu Lys Ile

35 40 45Lys Ala Lys Lys Gly Ser Val Trp Val Leu Ser Phe His Asp Gly Val

505560 Phe Thr Gly Ala Asp Tyr Leu Ala Ser Ser Leu Pro Val Lys 657075<210>1043<211>651<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (628)<223>RXA01528<400>1043cacccaaacc caaacctctc agtcgaataa gcagaagtct caggacaacc gcaggggtaa 60gggtcgtagg tctccaacca ggaggcgttc caacacgagg gtg aat cag gcg tgg 115

Val Asn Gln Ala Trp

1 5cag cag tcc cgt ttg gtt act tct gat gag act tcc gca ggt ggt ctc 163Gln Gln Ser Arg Leu Val Thr Ser Asp Glu Thr Ser Ala Gly Gly Leu

10 15 20gtg gtg tca ggt ttg gct gag gcg gtc aac gct aac aat gag gtt gat 211Val Val Ser Gly Leu Ala Glu Ala Val Asn Ala Asn Asn Glu Val Asp

25 30 35ctg tcg aag att tat gtt gcg ttg att ggt cgc ctt gat cgt cgt ggt 259Leu Ser Lys Ile Tyr Val Ala Leu Ile Gly Arg Leu Asp Arg Arg Gly

40 45 50cgt ttg ttg tgg tcg atg ccg aag ggc cat gtt gag cct ggt gag gat 307Arg Leu Leu Trp Ser Met Pro Lys Gly His Val Glu Pro Gly Glu Asp

55 60 65aag gct gcg act gct gag cgt gag gtg tgg gag gag acc ggc atc cac 355Lys Ala Ala Thr Ala Glu Arg Glu Val Trp Glu Glu Thr Gly Ile His70 75 80 85ggt gag gtg ttc act gag ttg ggt gtg att gat tat tgg ttc gtt tcg 403Gly Glu Val Phe Thr Glu Leu Gly Val Ile Asp Tyr Trp Phe Val Ser

90 95 100gaa ggg aag cgg atc cat aag acg gtg cat cat cat ttg ttg cgt tat 451Glu Gly Lys Arg Ile His Lys Thr Val His His His Leu Leu Arg Tyr

105 110 115gtt gat ggc gat ttg aat gat gag gat cca gaa gtc act gag gtg gcg 499Val Asp Gly Asp Leu Asn Asp Glu Asp Pro Glu Val Thr Glu Val Ala

120 125 130tgg att ccg gcg aat cag ttg att gag cat ttg gct ttt gcg gat gag 547Trp Ile Pro Ala Asn Gln Leu Ile Glu His Leu Ala Phe Ala Asp Glu

135 140 145cgg aag ttg gct agg cag gcg cat gat ttg ttg cct gag ttt gct ttg 595Arg Lys Leu Ala Arg Gln Ala His Asp Leu Leu Pro Glu Phe Ala Leu150 155 160 165aag gaa aag gcg gag gga agg tcc acc cca agg tgattccgaa ccccaacccg 648Lys Glu Lys Ala Glu Gly Arg Ser Thr Pro Arg

170175 aac 651<210>1044<211>176<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1044Val Asn Gln Ala Trp Gln Gln Ser Arg Leu Val Thr Ser Asp Glu Thr 151015 Ser Ala Gly Gly Leu Val Val Ser Gly Leu Ala Glu Ala Val Asn Ala

20 25 30Asn Asn Glu Val Asp Leu Ser Lys Ile Tyr Val Ala Leu Ile Gly Arg

35 40 45Leu Asp Arg Arg Gly Arg Leu Leu Trp Ser Met Pro Lys Gly His Val

50 55 60Glu Pro Gly Glu Asp Lys Ala Ala Thr Ala Glu Arg Glu Val Trp Glu 65 70 75 80Glu Thr Gly Ile His Gly Glu Val Phe Thr Glu Leu Gly Val Ile Asp

85 90 95Tyr Trp Phe Val Ser Glu Gly Lys Arg Ile His Lys Thr Val His His

100 105 110His Leu Leu Arg Tyr Val Asp Gly Asp Leu Asn Asp Glu Asp Pro Glu

115 120 125Val Thr Glu Val Ala Trp Ile Pro Ala Asn Gln Leu Ile Glu His Leu

130 135 140Ala Phe Ala Asp Glu Arg Lys Leu Ala Arg Gln Ala His Asp Leu Leu145 150 155 160Pro Glu Phe Ala Leu Lys Glu Lys Ala Glu Gly Arg Ser Thr Pro Arg

165170175<210>1045<211>541<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (541)<223>RXA00072<400>1045acggccagga cgatccagtg cacaggccag caccagcaaa gtccacatcg caagcattaa 60aagaatctct cgaaagacac aaaagaggtg agtcgcaaca atg agc ttt caa cta 115

Met Ser Phe Gln Leu

1 5gtt aac gcc ctg aaa aat act ggt tcg gta aaa gat ccc gag atc tca 163Val Asn Ala Leu Lys Asn Thr Gly Ser Val Lys Asp Pro Glu Ile Ser

10 15 20ccc gaa gga cct cgc acg acc aca ccg ttg tca cca gag gta gca aaa 211Pro Glu Gly Pro Arg Thr Thr Thr Pro Leu Ser Pro Glu Val Ala Lys

25 30 35cat aac gag gaa ctc gtc gaa aag cat gct gct gcg ttg tat gac gcc 259His Asn Glu Glu Leu Val Glu Lys His Ala Ala Ala Leu Tyr Asp Ala

40 45 50agc gcg caa gag atc ctg gaa tgg aca gcc gag cac gcg ccg ggc gct 307Ser Ala Gln Glu Ile Leu Glu Trp Thr Ala Glu His Ala Pro Gly Ala

55 60 65att gca gtg acc ttg agc atg gaa aac acc gtg ctg gcg gag ctg gct 355Ile Ala Val Thr Leu Ser Met Glu Asn Thr Val Leu Ala Glu Leu Ala 70 75 80 85gcg cgg cac ctg ccg gaa gct gat ttc ctc ttt ttg gac acc ggt tac 403Ala Arg His Leu Pro Glu Ala Asp Phe Leu Phe Leu Asp Thr Gly Tyr

9095 100cac ttc aag gag acc ctt gaa gtt gcc cgt cag gta gat gag cgc tat 451His Phe Lys Glu Thr Leu Glu Val Ala Arg Gln Val Asp Glu Arg Tyr

105 110 115tcc cag aag ctt gtc acc gcg ctg ccg atc ctc aag cgc acg gag cag 499Ser Gln Lys Leu Val Thr Ala Leu Pro Ile Leu Lys Arg Thr Glu Gln

120 125 130gat tcc att tat ggt ctc aac ctg tac cgc agc aac cca gcg 541Asp Ser Ile Tyr Gly Leu Asn Leu Tyr Arg Ser Asn Pro Ala

135140145<210>1046<211>147<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1046Met Ser Phe Gln Leu Val Asn Ala Leu Lys Asn Thr Gly Ser Val Lys 151015 Asp Pro Glu Ile Ser Pro Glu Gly Pro Arg Thr Thr Thr Pro Leu Ser

20 25 30Pro Glu Val Ala Lys His Asn Glu Glu Leu Val Glu Lys His Ala Ala

35 40 45Ala Leu Tyr Asp Ala Ser Ala Gln Glu Ile Leu Glu Trp Thr Ala Glu

50 55 60His Ala Pro Gly Ala Ile Ala Val Thr Leu Ser Met Glu Asn Thr Val 65 70 75 80Leu Ala Glu Leu Ala Ala Arg His Leu Pro Glu Ala Asp Phe Leu Phe

85 90 95Leu Asp Thr Gly Tyr His Phe Lys Glu Thr Leu Glu Val Ala Arg Gln

100 105 110Val Asp Glu Arg Tyr Ser Gln Lys Leu Val Thr Ala Leu Pro Ile Leu

115 120 125Lys Arg Thr Glu Gln Asp Ser Ile Tyr Gly Leu Asn Leu Tyr Arg Ser

130135140 Asn Pro Ala145<210>1047<211>1002<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (979)<223>RXA01878<400>1047ggttcaggct gcacaaggtt ggggagcatg gcctgcttgc accgcaagct tgggcatccg 60atagtagaaa tctggcatcc aataggtaga ttgggatgct atg gaa gaa ccc tca 115

Met Glu Glu Pro Ser

1 5ggt gca cag ctg ctc ggc ccg gta gaa atc cgt gcg ctg gca gaa aag 163Gly Ala Gln Leu Leu Gly Pro Val Glu Ile Arg Ala Leu Ala Glu Lys

10 15 20ctc gac gtc aca cca act aag aag ttg ggg cag aac ttt gtt cac gat 211Leu Asp Val Thr Pro Thr Lys Lys Leu Gly Gln Asn Phe Val His Asp

25 30 35ccc aac acg gtg cgt cgc att gtt gct gcg gca gag ctc acc cca aac 259Pro Asn Thr Val Arg Arg Ile Val Ala Ala Ala Glu Leu Thr Pro Asn

40 45 50gac cac gtg gtg gaa gtt ggc cct ggt ctg ggc tct ctg acc ctt gcc 307Asp His Val Val Glu Val Gly Pro Gly Leu Gly Ser Leu Thr Leu Ala

55 60 65ctg gtg gaa tct gct gct tca gta act gcg gtg gaa att gat ccc cgt 355Leu Val Glu Ser Ala Ala Ser Val Thr Ala Val Glu Ile Asp Pro Arg 70 75 80 85ttg gct gcg gaa ttg ccg gag act ttt cag tgg cgc gcg ccg gcc ctt 403Leu Ala Ala Glu Leu Pro Glu Thr Phe Gln Trp Arg Ala Pro Ala Leu

90 95 100gct cac aag ttg agc atc gtg ctg aaa gac gcc ctg aag gtt caa caa 451Ala His Lys Leu Ser Ile Val Leu Lys Asp Ala Leu Lys Val Gln Gln

105 110 115tcc gat atg gct gtt caa ccc acc gcc ttg gtg gct aac ttg ccg tac 499Ser Asp Met Ala Val Gln Pro Thr Ala Leu Val Ala Asn Leu Pro Tyr

120 125 130aac gtc tct gtc cct gtc ttg ttg cac atg atg gag gag ttt ccc acc 547Asn Val Ser Val Pro Val Leu Leu His Met Met Glu Glu Phe Pro Thr

135 140 145atc aac aag gtg ctt gtc atg gtg cag gca gag gtt gct gat cgt ttg 595Ile Asn Lys Val Leu Val Met Val Gln Ala Glu Val Ala Asp Arg Leu150 155 160 165gct gcg gat cca gga tcg aag att tat ggt gtg cct agc gtg aag gcg 643Ala Ala Asp Pro Gly Ser Lys Ile Tyr Gly Val Pro Ser Val Lys Ala

170 175 180tcc ttc tac ggt cca gtt act cgc gcc ggg tcg att ggt aag aat gtc 691Ser Phe Tyr Gly Pro Val Thr Arg Ala Gly Ser Ile Gly Lys Asn Val

185 190 195ttt tgg cca gct cca aag atc gaa tcc ggt ttg gtg aag atc gtg cgc 739Phe Trp Pro Ala Pro Lys Ile Glu Ser Gly Leu Val Lys Ile Val Arg

200 205 210gaa gac acc gcg tgg aag cag gac gat gag acg cgt aag aag gtg tgg 787Glu Asp Thr Ala Trp Lys Gln Asp Asp Glu Thr Arg Lys Lys Val Trp

215 220 225ccg atc att gat gct gct ttc ttg cag cgc cgt aaa acc cta aga gct 835Pro Ile Ile Asp Ala Ala Phe Leu Gln Arg Arg Lys Thr Leu Arg Ala230 235 240 245gcg ctt tct gga cac tac ggt tct ggc cag gca gct gag gaa gct ttg 883Ala Leu Ser Gly His Tyr Gly Ser Gly Gln Ala Ala Glu Glu Ala Leu

250 255 260cgg gcc gct gat att gat cca acg ctt cgt ggc gaa aag ctt gat gtc 931Arg Ala Ala Asp Ile Asp Pro Thr Leu Arg Gly Glu Lys Leu Asp Val

265 270 275act gac tat gtg cgc cta gct ggg gtg ttg cag caa aag gat gag aag 979Thr Asp Tyr Val Arg Leu Ala Gly Val Leu Gln Gln Lys Asp Glu Lys

280285290 tgaaaattac cgctaaggcg tgg 1002<210>1048<211>293<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1048Met Glu Glu Pro Ser Gly Ala Gln Leu Leu Gly Pro Val Glu Ile Arg 151015 Ala Leu Ala Glu Lys Leu Asp Val Thr Pro Thr Lys Lys Leu Gly Gln

20 25 30Asn Phe Val His Asp Pro Asn Thr Val Arg Arg Ile Val Ala Ala Ala

35 40 45Glu Leu Thr Pro Asn Asp His Val Val Glu Val Gly Pro Gly Leu Gly

50 55 60Ser Leu Thr Leu Ala Leu Val Glu Ser Ala Ala Ser Val Thr Ala Val 65 70 75 80Glu Ile Asp Pro Arg Leu Ala Ala Glu Leu Pro Glu Thr Phe Gln Trp

85 90 95Arg Ala Pro Ala Leu Ala His Lys Leu Ser Ile Val Leu Lys Asp Ala

100 105 110Leu Lys Val Gln Gln Ser Asp Met Ala Val Gln Pro Thr Ala Leu Val

115 120 125Ala Asn Leu Pro Tyr Asn Val Ser Val Pro Val Leu Leu His Met Met

130 135 140Glu Glu Phe Pro Thr Ile Asn Lys Val Leu Val Met Val Gln Ala Glu145 150 155 160Val Ala Asp Arg Leu Ala Ala Asp Pro Gly Ser Lys Ile Tyr Gly Val

165 170 175Pro Ser Val Lys Ala Ser Phe Tyr Gly Pro Val Thr Arg Ala Gly Ser

180 185 190Ile Gly Lys Asn Val Phe Trp Pro Ala Pro Lys Ile Glu Ser Gly Leu

195 200 205Val Lys Ile Val Arg Glu Asp Thr Ala Trp Lys Gln Asp Asp Glu Thr

210 215 220Arg Lys Lys Val Trp Pro Ile Ile Asp Ala Ala Phe Leu Gln Arg Arg225 230 235 240Lys Thr Leu Arg Ala Ala Leu Ser Gly His Tyr Gly Ser Gly Gln Ala

245 250 255Ala Glu Glu Ala Leu Arg Ala Ala Asp Ile Asp Pro Thr Leu Arg Gly

260 265 270Glu Lys Leu Asp Val Thr Asp Tyr Val Arg Leu Ala Gly Val Leu Gln

275 280 285Gln Lys Asp Glu Lys

290<210>1049<211>1545<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1531)<223>RXN02281<400>1049aagatcaaca acgccgccga ggtcaacttg gaaattatca cgtgaggatt cttgcatacg 60cctataaaag cacagttttg aatccacagg gcatcagggc gtg cag aaa gat agt 115

Val Gln Lys Asp Ser

1 5gtg gtg cgc atg gaa gca aca acg atc gat gac gca atc gcg aag ctc 163Val Val Arg Met Glu Ala Thr Thr Ile Asp Asp Ala Ile Ala Lys Leu

10 15 20att gac atc tac gac acc tcg acc aaa ctg gcc aaa gaa acc ctc aac 211Ile Asp Ile Tyr Asp Thr Ser Thr Lys Leu Ala Lys Glu Thr Leu Asn

25 30 35aat gag gactac gcc gca tac gcc gat gtt gtt tac ccc aaa ctc acc 259Asn Glu Asp Tyr Ala Ala Tyr Ala Asp Val Val Tyr Pro Lys Leu Thr

40 45 50 gtt gac gtg ctg gaa tgg aaa ccc atc gac cgc acc gaa ccc ttc ggc 307Val Asp Val Leu Glu Trp Lys Pro Ile Asp Arg Thr Glu Pro Phe Gly

55 60 65tat gtg gat cga gcc ggg cga tac tcc gcc acc ttg tcc aaa cca cgc 355Tyr Val Asp Arg Ala Gly Arg Tyr Ser Ala Thr Leu Ser Lys Pro Arg 70 75 80 85gtg att gag cgt tac ctc cgc gaa caa ctc gag cgt ctc acc agt aat 403Val Ile Glu Arg Tyr Leu Arg Glu Gln Leu Glu Arg Leu Thr Ser Asn

90 95 100tat ccc tgc aag att tac gta tct gag tca gat atc cgc atc cca ccg 451Tyr Pro Cys Lys Ile Tyr Val Ser Glu Ser Asp Ile Arg Ile Pro Pro

105 110 115gag tac att cgc ggc gca cct tcc gct acc gaa gct cgc cgt gct ggt 499Glu Tyr Ile Arg Gly Ala Pro Ser Ala Thr Glu Ala Arg Arg Ala Gly

120 125 130gat gtt gca gat atc atc cca cgc ccc acc ctg gat gaa gtc cac gac 547Asp Val Ala Asp Ile Ile Pro Arg Pro Thr Leu Asp Glu Val His Asp

135 140 145gca att atc gac ggc gac tgg cac gcc ttc aac ggc ccc gaa ctc ccg 595Ala Ile Ile Asp Gly Asp Trp His Ala Phe Asn Gly Pro Glu Leu Pro150 155 160 165ctt ttc cac ttc ggg ccg caa cgc ttc gac atc gcc tgc gcc cgc atc 643Leu Phe His Phe Gly Pro Gln Arg Phe Asp Ile Ala Cys Ala Arg Ile

170 175 180gag cac tac acc ggc atc aac gtg gaa cac gtg cag aag tac att ctg 691Glu His Tyr Thr Gly Ile Asn Val Glu His ValGln Lys Tyr Ile Leu

185 190 195ttc acc aac tac gcc atg cac acc acc gag ttc gtg cat ttt gcc atg 739Phe Thr Asn Tyr Ala Met His Thr Thr Glu Phe Val His Phe Ala Met

200 205 210tcc gaa ctc acc tcg gaa gac tcc cgc tac gtg ggt cta tcc ttg cca 787Ser Glu Leu Thr Ser Glu Asp Ser Arg Tyr Val Gly Leu Ser Leu Pro

215 220 225aac ggg cag gta att gac cga gag acc gcc acc agc ctc ggt acg gaa 835Asn Gly Gln Val Ile Asp Arg Glu Thr Ala Thr Ser Leu Gly Thr Glu230 235 240 245acc ctt gat ctg act agc cgt ttc caa atg cct cgt tac gat ctc atc 883Thr Leu Asp Leu Thr Ser Arg Phe Gln Met Pro Arg Tyr Asp Leu Ile

250 255 260acc gaa gcc ggt gac ggt att acc att atc aac atc ggt gtg ggc cca 931Thr Glu Ala Gly Asp Gly Ile Thr Ile Ile Asn Ile Gly Val Gly Pro

265 270 275tcc aat gca aaa act atc acc gac tgc ctt gct gtg ctc cgc cca gaa 979Ser Asn Ala Lys Thr Ile Thr Asp Cys Leu Ala Val Leu Arg Pro Glu

280 285 290gcc tgg gtg atg atc ggc cac tgt gct ggc atg gac gcc cgc atg cgc 1027Ala Trp Val Met Ile Gly His Cys Ala Gly Met Asp Ala Arg Met Arg

295 300 305atc ggc gac ctc atc ctt ggc aac gcc tac cag cgc gaa gac cac att 1075Ile Gly Asp Leu Ile Leu Gly Asn Ala Tyr Gln Arg Glu Asp His Ile310 315 320 325ctg aat acc cgc atc cca ctt ggt aat ccg atc ccg gca ata cca gaa 1123Leu Asn Thr Arg Ile Pro Leu Gly Asn Pro Ile Pro Ala Ile Pro Glu

330 335340atc caa aaa gct cta gaa gcc agc gtc gac gaa atc tac gga tcc gac 1171Ile Gln Lys Ala Leu Glu Ala Ser Val Asp Glu Ile Tyr Gly Ser Asp

345 350 355aac agc ctc atg cgc acc ggt acg gtc tta tcc acc gac gac cga aac 1219Asn Ser Leu Met Arg Thr Gly Thr Val Leu Ser Thr Asp Asp Arg Asn

360 365 370tgg gaa tgg cac acc cca gaa aac ctc tgg aac tgg ctc aaa gga tcc 1267Trp Glu Trp His Thr Pro Glu Asn Leu Trp Asn Trp Leu Lys Gly Ser

375 380 385acc gcc gca gct gtt gac atg gaa tct tcc acc ttg gcc acc aac gga 1315Thr Ala Ala Ala Val Asp Met Glu Ser Ser Thr Leu Ala Thr Asn Gly390 395 400 405tat cga ttc cgc att cca tac ggc acc ctg ctg agc gtc tct gac ctg 1363Tyr Arg Phe Arg Ile Pro Tyr Gly Thr Leu Leu Ser Val Ser Asp Leu

410 415 420cca cta cac gca gtg ccg aaa ctt tcc gcg caa gcg cag gcg ttt tac 1411Pro Leu His Ala Val Pro Lys Leu Ser Ala Gln Ala Gln Ala Phe Tyr

425 430 435ttc aac tcc aag gaa gcc cac gtc atg tgt gct gtt cgt gca atg gaa 1459Phe Asn Ser Lys Glu Ala His Val Met Cys Ala Val Arg Ala Met Glu

440 445 450tac ctg gca gta gat cct gaa cgg ttg cgt acc cgt aaa ctg cgc agg 1507Tyr Leu Ala Val Asp Pro Glu Arg Leu Arg Thr Arg Lys Leu Arg Arg

455460465 acc ttg ggt gag gtg ccg ttt cgc taaagtctcg gaga 1545Thr Leu Gly Glu Val Pro Phe Arg 470475<210>1050<211>477<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1050Val Gln Lys Asp Ser Val Val Arg Met Glu Ala Thr Thr Ile Asp Asp 151015 Ala Ile Ala Lys Leu IleAsp Ile Tyr Asp Thr Ser Thr Lys Leu Ala

20 25 30Lys Glu Thr Leu Asn Asn Glu Asp Tyr Ala Ala Tyr Ala Asp Val Val

35 40 45Tyr Pro Lys Leu Thr Val Asp Val Leu Glu Trp Lys Pro Ile Asp Arg

50 55 60Thr Glu Pro Phe Gly Tyr Val Asp Arg Ala Gly Arg Tyr Ser Ala Thr 65 70 75 80Leu Ser Lys Pro Arg Val Ile Glu Arg Tyr Leu Arg Glu Gln Leu Glu

85 90 95Arg Leu Thr Ser Asn Tyr Pro Cys Lys Ile Tyr Val Ser Glu Ser Asp

100 105 110Ile Arg Ile Pro Pro Glu Tyr Ile Arg Gly Ala Pro Ser Ala Thr Glu

115 120 125Ala Arg Arg Ala Gly Asp Val Ala Asp Ile Ile Pro Arg Pro Thr Leu

130 135 140Asp Glu Val His Asp Ala Ile Ile Asp Gly Asp Trp His Ala Phe Asn145 150 155 160Gly Pro Glu Leu Pro Leu Phe His Phe Gly Pro Gln Arg Phe Asp Ile

165 170 175Ala Cys Ala Arg Ile Glu His Tyr Thr Gly Ile Asn Val Glu His Val

180 185 190Gln Lys Tyr Ile Leu Phe Thr Asn Tyr Ala Met His Thr Thr Glu Phe

195 200 205Val His Phe Ala Met Ser Glu Leu Thr Ser Glu Asp Ser Arg Tyr Val

210 215 220Gly Leu Ser Leu Pro Asn Gly Gln Val Ile Asp Arg Glu Thr Ala Thr225 230 235 240Ser Leu Gly Thr Glu ThrLeu Asp Leu Thr Ser Arg Phe Gln Met Pro

245 250 255Arg Tyr Asp Leu Ile Thr Glu Ala Gly Asp Gly Ile Thr Ile Ile Asn

260 265 270Ile Gly Val Gly Pro Ser Asn Ala Lys Thr Ile Thr Asp Cys Leu Ala

275 280 285Val Leu Arg Pro Glu Ala Trp Val Met Ile Gly His Cys Ala Gly Met

290 295 300Asp Ala Arg Met Arg Ile Gly Asp Leu Ile Leu Gly Asn Ala Tyr Gln305 310 315 320Arg Glu Asp His Ile Leu Asn Thr Arg Ile Pro Leu Gly Asn Pro Ile

325 330 335Pro Ala Ile Pro Glu Ile Gln Lys Ala Leu Glu Ala Ser Val Asp Glu

340 345 350Ile Tyr Gly Ser Asp Asn Ser Leu Met Arg Thr Gly Thr Val Leu Ser

355 360 365Thr Asp Asp Arg Asn Trp Glu Trp His Thr Pro Glu Asn Leu Trp Asn

370 375 380Trp Leu Lys Gly Ser Thr Ala Ala Ala Val Asp Met Glu Ser Ser Thr385 390 395 400Leu Ala Thr Asn Gly Tyr Arg Phe Arg Ile Pro Tyr Gly Thr Leu Leu

405 410 415Ser Val Ser Asp Leu Pro Leu His Ala Val Pro Lys Leu Ser Ala Gln

420 425 430Ala Gln Ala Phe Tyr Phe Asn Ser Lys Glu Ala His Val Met Cys Ala

435 440 445Val Arg Ala Met Glu Tyr Leu Ala Val Asp Pro Glu Arg Leu Arg Thr

450455460 Arg Lys Leu Arg Arg Thr LeuGly Glu Val Pro Phe Arg 465470475<210>1051<211>1191<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1168)<223>FRXA02281<400>1051aagatcaaca acgccgccga ggtcaacttg gaaattatca cgtgaggatt cttgcatacg 60cctataaaag cacagttttg aatccacagg gcatcagggc gtg cag aaa gat agt 115

Val Gln Lys Asp Ser

1 5gtg gtg cgc atg gaa gca aca acg atc gat gac gca atc gcg aag ctc 163Val Val Arg Met Glu Ala Thr Thr Ile Asp Asp Ala Ile Ala Lys Leu

10 15 20att gac atc tac gac acc tcg acc aaa ctg gcc aaa gaa acc ctc aac 211Ile Asp Ile Tyr Asp Thr Ser Thr Lys Leu Ala Lys Glu Thr Leu Asn

25 30 35aat gag gac tac gcc gca tac gcc gat gtt gtt tac ccc aaa ctc acc 259Asn Glu Asp Tyr Ala Ala Tyr Ala Asp Val Val Tyr Pro Lys Leu Thr

40 45 50gtt gac gtg ctg gaa tgg aaa ccc atc gac cgc acc gaa ccc ttc ggc 307Val Asp Val Leu Glu Trp Lys Pro Ile Asp Arg Thr Glu Pro Phe Gly

55 60 65tat gtg gat cga gcc ggg cga tac tcc gcc acc ttg tcc aaa cca cgc 355Tyr Val Asp Arg Ala Gly Arg Tyr Ser Ala Thr Leu Ser Lys Pro Arg 70 75 80 85gtg att gag cgt tac ctc cgc gaa caa ctc gag cgt ctc acc agt aat 403Val Ile Glu Arg Tyr Leu Arg Glu Gln Leu Glu Arg Leu Thr Ser Asn

90 95 100tat ccc tgc aag att tac gta tct gag tca gat atc cgc atc cca ccg 451Tyr Pro Cys Lys Ile Tyr Val Ser Glu Ser Asp Ile Arg Ile Pro Pro

105 110 115gag tac att cgc ggc gca cct tcc gct acc gaa gct cgc cgt gct ggt 499Glu Tyr Ile Arg Gly Ala Pro Ser Ala Thr Glu Ala Arg Arg Ala Gly

120 125 130gat gtt gca gat atc atc cca cgc ccc acc ctg gat gaa gtc cac gac 547Asp Val Ala Asp Ile Ile Pro Arg Pro Thr Leu Asp Glu Val His Asp

135 140 145gca att atc gac ggc gac tgg cac gcc ttc aac ggc ccc gaa ctc ccg 595Ala Ile Ile Asp Gly Asp Trp His Ala Phe Asn Gly Pro Glu Leu Pro150 155 160 165ctt ttc cac ttc ggg ccg caa cgc ttc gac atc gcc tgc gcc cgc atc 643Leu Phe His Phe Gly Pro Gln Arg Phe Asp Ile Ala Cys Ala Arg Ile

170 175 180gag cac tac acc ggc atc aac gtg gaa cac gtg cag aag tac att ctg 691Glu His Tyr Thr Gly Ile Asn Val Glu His Val Gln Lys Tyr Ile Leu

185 190 195ttc acc aac tac gcc atg cac acc acc gag ttc gtg cat ttt gcc atg 739Phe Thr Asn Tyr Ala Met His Thr Thr Glu Phe Val His Phe Ala Met

200 205 210tcc gaa ctc acc tcg gaa gac tcc cgc tac gtg ggt cta tcc ttg cca 787Ser Glu Leu Thr Ser Glu Asp Ser Arg Tyr Val Gly Leu Ser Leu Pro

215 220 225aac ggg cag gta att gac cga gag acc gcc acc agc ctc ggt acg gaa 835Asn Gly Gln Val Ile Asp Arg Glu Thr Ala Thr Ser Leu Gly Thr Glu230 235 240 245acc ctt gat ctg act agc cgt ttc caa atg cct cgt tac gat ctc atc 883Thr Leu Asp Leu Thr Ser Arg Phe Gln Met Pro Arg Tyr Asp Leu Ile

250 255 260acc gaa gcc ggt gac ggt att acc attatc aac atc ggt gtg ggc cca 931Thr Glu Ala Gly Asp Gly Ile Thr Ile Ile Asn Ile Gly Val Gly Pro

265 270 275tcc aat gca aaa act atc acc gac tgc ctt gct gtg ctc cgc cca gaa 979Ser Asn Ala Lys Thr Ile Thr Asp Cys Leu Ala Val Leu Arg Pro Glu

280 285 290gcc tgg gtg atg atc ggc cac tgt gct ggc atg gac gcc cgc atg cgc 1027Ala Trp Val Met Ile Gly His Cys Ala Gly Met Asp Ala Arg Met Arg

295 300 305atc ggc gac ctc atc ctt ggc aac gcc tac cag cgc gaa gac cac att 1075Ile Gly Asp Leu Ile Leu Gly Asn Ala Tyr Gln Arg Glu Asp His Ile310 315 320 325ctg aat acc cgc atc cca ctt ggt aat ccg atc ccg gca ata cca gaa 1123Leu Asn Thr Arg Ile Pro Leu Gly Asn Pro Ile Pro Ala Ile Pro Glu

330 335 340atc caa aaa gct cta gaa gcc agc gtc gac gaa atc tac gga tcc 1168Ile Gln Lys Ala Leu Glu Ala Ser Val Asp Glu Ile Tyr Gly Ser

345350355 tagtattcta tagtgtcacc taa 1191<210>1052<211>356<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1052Val Gln Lys Asp Ser Val Val Arg Met Glu Ala Thr Thr Ile Asp Asp 151015 Ala Ile Ala Lys Leu Ile Asp Ile Tyr Asp Thr Ser Thr Lys Leu Ala

20 25 30Lys Glu Thr Leu Asn Asn Glu Asp Tyr Ala Ala Tyr Ala Asp Val Val

35 40 45Tyr Pro Lys Leu Thr Val Asp Val Leu Glu Trp Lys Pro Ile Asp Arg

50 55 60Thr Glu Pro Phe Gly Tyr Val Asp Arg Ala Gly Arg Tyr Ser Ala Thr 65 70 75 80Leu SerLys Pro Arg Val Ile Glu Arg Tyr Leu Arg Glu Gln Leu Glu

85 90 95Arg Leu Thr Ser Asn Tyr Pro Cys Lys Ile Tyr Val Ser Glu Ser Asp

100 105 110Ile Arg Ile Pro Pro Glu Tyr Ile Arg Gly Ala Pro Ser Ala Thr Glu

115 120 125Ala Arg Arg Ala Gly Asp Val Ala Asp Ile Ile Pro Arg Pro Thr Leu

130 135 140Asp Glu Val His Asp Ala Ile Ile Asp Gly Asp Trp His Ala Phe Asn145 150 155 160Gly Pro Glu Leu Pro Leu Phe His Phe Gly Pro Gln Arg Phe Asp Ile

165 170 175Ala Cys Ala Arg Ile Glu His Tyr Thr Gly Ile Asn Val Glu His Val

180 185 190Gln Lys Tyr Ile Leu Phe Thr Asn Tyr Ala Met His Thr Thr Glu Phe

195 200 205Val His Phe Ala Met Ser Glu Leu Thr Ser Glu Asp Ser Arg Tyr Val

210 215 220Gly Leu Ser Leu Pro Asn Gly Gln Val Ile Asp Arg Glu Thr Ala Thr225 230 235 240Ser Leu Gly Thr Glu Thr Leu Asp Leu Thr Ser Arg Phe Gln Met Pro

245 250 255Arg Tyr Asp Leu Ile Thr Glu Ala Gly Asp Gly Ile Thr Ile Ile Asn

260 265 270Ile Gly Val Gly Pro Ser Asn Ala Lys Thr Ile Thr Asp Cys Leu Ala

275 280 285Val Leu Arg Pro Glu Ala Trp Val Met Ile Gly His Cys Ala Gly Met

290 295 300Asp Ala Arg Met Arg Ile Gly Asp Leu Ile Leu Gly Asn Ala Tyr Gln305 310 315 320Arg Glu Asp His Ile Leu Asn Thr Arg Ile Pro Leu Gly Asn Pro Ile

325 330 335Pro Ala Ile Pro Glu Ile Gln Lys Ala Leu Glu Ala Ser Val Asp Glu

340 345 350Ile Tyr Gly Ser

355<210>1053<211>1146<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1123)<223>RXN01240<400>1053ttgttctcac atctacccgt atctttgttg gttttagtac ccgatagtga gttttgatcc 60ctgcacagga aagttagcgg cgctactatg aacgatcgat atg tct gac aac act 115

Met Ser Asp Asn Thr

1 5ctc tcc caa ttt ggc agt tac tac cac gaa ttc cga cgt gcc cat ccc 163Leu Ser Gln Phe Gly Ser Tyr Tyr His Glu Phe Arg Arg Ala His Pro

10 15 20atg gcc gac gtc gaa ttc ctc cta gca att gaa gaa tta ctt acg gac 211Met Ala Asp Val Glu Phe Leu Leu Ala Ile Glu Glu Leu Leu Thr Asp

25 30 35ggt ggt gtc acc ttc gat cgc gtc acc aca cgc atc aaa gaa tgg tca 259Gly Gly Val Thr Phe Asp Arg Val Thr Thr Arg Ile Lys Glu Trp Ser

40 45 50agc ctg aaa gcc aag gct cgc aag cgt cgc aac gat ggc tcg ttg atc 307Ser Leu Lys Ala Lys Ala Arg Lys Arg Arg Asn Asp Gly Ser Leu Ile

55 60 65tac cct gat ccg cgc aaa gac atc cac gac atg atc ggt gtt cgg atc 355Tyr Pro Asp Pro Arg Lys Asp Ile His Asp Met Ile Gly Val Arg Ile 70 75 80 85acc acg tac cac tcc acg gaa ata ccc gtg gcc cta aaa gtg ctc caa 403Thr Thr Tyr His Ser Thr Glu Ile Pro Val Ala Leu Lys Val Leu Gln

90 95 100gac tcc ttc atc gtc cac aaa tcc gta gac aaa gcc gct gaa act cgc 451Asp Ser Phe Ile Val His Lys Ser Val Asp Lys Ala Ala Glu Thr Arg

105 110 115atc tca ggc ggc ttt ggt tac ggc tcc cac cac ctg att ctg gaa gtc 499Ile Ser Gly Gly Phe Gly Tyr Gly Ser His His Leu Ile Leu Glu Val

120 125 130gat gac acc tcc gat gac ctc cag gac tac aaa ggc ctc gtc ttt gaa 547Asp Asp Thr Ser Asp Asp Leu Gln Asp Tyr Lys Gly Leu Val Phe Glu

135 140 145gtt cag gtg cgc acc gtg ctg caa cac gcc tgg gca gag ttc gaa cac 595Val Gln Val Arg Thr Val Leu Gln His Ala Trp Ala Glu Phe Glu His150 155 160 165gat atc cgc tat aaa cgc gcc gat gtg tcc aac cca gaa gac ttc agc 643Asp Ile Arg Tyr Lys Arg Ala Asp Val Ser Asn Pro Glu Asp Phe Ser

170 175 180gca gaa gta gac cgc atg ttc acc ctc gct gcc gga ctc atc gaa tta 691Ala Glu Val Asp Arg Met Phe Thr Leu Ala Ala Gly Leu Ile Glu Leu

185 190 195gcg gac caa caa ttc gac caa atc gcc gca ctc aaa gaa acc agc cga 739Ala Asp Gln Gln Phe Asp Gln Ile Ala Ala Leu Lys Glu Thr Ser Arg

200 205 210gtt gct gat gaa tcc gtc gaa ctc acc gca gag aca ctt ccc ggc gtt 787Val Ala Asp Glu Ser Val Glu Leu Thr Ala Glu Thr Leu Pro Gly Val

215 220225ctt gcc atg ctc att ggc aac cgc ttc ccc cgc cca cgc tcc aca aac 835Leu Ala Met Leu Ile Gly Asn Arg Phe Pro Arg Pro Arg Ser Thr Asn230 235 240 245tac cgc ttc ctc gaa gac atc ctg gtg gcc aac tcc att acc tct gtg 883Tyr Arg Phe Leu Glu Asp Ile Leu Val Ala Asn Ser Ile Thr Ser Val

250 255 260gtg cag ctg cgc gag ctg ctc aac ccc acc gac att gaa gtg ctg ttg 931Val Gln Leu Arg Glu Leu Leu Asn Pro Thr Asp Ile Glu Val Leu Leu

265 270 275aaa gta atg aac tac cgc ttc cac cca ggc cag atc cgc atc atc gac 979Lys Val Met Asn Tyr Arg Phe His Pro Gly Gln Ile Arg Ile Ile Asp

280 285 290gat tta cta ctc aaa cga ttt ggc caa tca cac atc gat gcc acc gtc 1027Asp Leu Leu Leu Lys Arg Phe Gly Gln Ser His Ile Asp Ala Thr Val

295 300 305gcc acc gac tcc caa cca ctc aac gcc aaa cgc cac agg cag cta aaa 1075Ala Thr Asp Ser Gln Pro Leu Asn Ala Lys Arg His Arg Gln Leu Lys310 315 320 325cgc aag cta gag ctc atg acc caa gct cat ctt gtg gaa cca cca aac 1123Arg Lys Leu Glu Leu Met Thr Gln Ala His Leu Val Glu Pro Pro Asn

330335340 taaagttccc ccaaagttag ccc 1146<210>1054<211>341<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1054Met Ser Asp Asn Thr Leu Ser Gln Phe Gly Ser Tyr Tyr His Glu Phe 151015 Arg Arg Ala His Pro Met Ala Asp Val Glu Phe Leu Leu Ala Ile Glu

20 25 30Glu Leu Leu Thr Asp Gly Gly Val Thr Phe Asp Arg Val Thr Thr Arg

35 40 45Ile Lys Glu Trp Ser Ser Leu Lys Ala Lys Ala Arg Lys Arg Arg Asn

50 55 60Asp Gly Ser Leu Ile Tyr Pro Asp Pro Arg Lys Asp Ile His Asp Met 65 70 75 80Ile Gly Val Arg Ile Thr Thr Tyr His Ser Thr Glu Ile Pro Val Ala

85 90 95Leu Lys Val Leu Gln Asp Ser Phe Ile Val His Lys Ser Val Asp Lys

100 105 110Ala Ala Glu Thr Arg Ile Ser Gly Gly Phe Gly Tyr Gly Ser His His

115 120 125Leu Ile Leu Glu Val Asp Asp Thr Ser Asp Asp Leu Gln Asp Tyr Lys

130 135 140Gly Leu Val Phe Glu Val Gln Val Arg Thr Val Leu Gln His Ala Trp145 150 155 160Ala Glu Phe Glu His Asp Ile Arg Tyr Lys Arg Ala Asp Val Ser Asn

165 170 175Pro Glu Asp Phe Ser Ala Glu Val Asp Arg Met Phe Thr Leu Ala Ala

180 185 190Gly Leu Ile Glu Leu Ala Asp Gln Gln Phe Asp Gln Ile Ala Ala Leu

195 200 205Lys Glu Thr Ser Arg Val Ala Asp Glu Ser Val Glu Leu Thr Ala Glu

210 215 220Thr Leu Pro Gly Val Leu Ala Met Leu Ile Gly Asn Arg Phe Pro Arg225 230 235 240Pro Arg Ser Thr Asn Tyr Arg Phe Leu Glu Asp Ile Leu Val Ala Asn

245 250 255Ser Ile Thr Ser Val Val Gln Leu Arg Glu Leu Leu Asn Pro Thr Asp

260 265 270Ile Glu Val Leu Leu Lys Val Met Asn Tyr Arg Phe His Pro Gly Gln

275 280 285Ile Arg Ile Ile Asp Asp Leu Leu Leu Lys Arg Phe Gly Gln Ser His

290 295 300Ile Asp Ala Thr Val Ala Thr Asp Ser Gln Pro Leu Asn Ala Lys Arg305 310 315 320His Arg Gln Leu Lys Arg Lys Leu Glu Leu Met Thr Gln Ala His Leu

325 330 335Val Glu Pro Pro Asn

340<210>1055<211>1234<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). - (1234)<223>RXN02008<400>1055tactggtcta tctatcaaaa gatgatcgtt cgcggtcgtg attttgacga tatttttgat 60cttgttggca tccgcatcct ggtagacaac gtgaacaact gtg tac gcc gcc atc 115

Val Tyr Ala Ala Ile

1 5ggt gtc gtg cac tcc ctg ttc aat gct ctg cct ggc cga ttc aaa gac 163Gly Val Val His Ser Leu Phe Asn Ala Leu Pro Gly Arg Phe Lys Asp

10 15 20tat att tca gcc ccg cgc ttc ggt gtc tac caa tcc ctg cac acc acc 211Tyr Ile Ser Ala Pro Arg Phe Gly Val Tyr Gln Ser Leu His Thr Thr

25 30 35gtg atg gga cct ggc ggt aag cct ctg gaa gtt cag gca cgt acc cac 259Val Met Gly Pro Gly Gly Lys Pro Leu Glu Val Gln Ala Arg Thr His

40 45 50gac atg cac tac aac gcc gaa ttc ggc att gca gcg cac tgg cga tac 307Asp Met His Tyr Asn Ala Glu Phe Gly Ile Ala Ala His Trp Arg Tyr

55 6065aaa gaa acc aaa ggc agc cac agt ggc gag caa gcc gaa gtg gat caa 355Lys Glu Thr Lys Gly Ser His Ser Gly Glu Gln Ala Glu Val Asp Gln 70 75 80 85atg gcg tgg atg cgc caa ctt ctg gac tgg caa aaa gaa gca gcc gac 403Met Ala Trp Met Arg Gln Leu Leu Asp Trp Gln Lys Glu Ala Ala Asp

90 95 100ccc aac gag ttc ctg gac agc ctg cgc tac gat ctg act tcc aag cag 451Pro Asn Glu Phe Leu Asp Ser Leu Arg Tyr Asp Leu Thr Ser Lys Gln

105 110 115atc ttc gtg ttc aca ccc aaa ggt gat gtg gtc aac ctg ccg gtg aac 499Ile Phe Val Phe Thr Pro Lys Gly Asp Val Val Asn Leu Pro Val Asn

120 125 130tcc acc ccg gtg gac ttc gcc tac gcg gtg cac acc gaa gtg ggg cac 547Ser Thr Pro Val Asp Phe Ala Tyr Ala Val His Thr Glu Val Gly His

135 140 145cgc tgc atc ggc gcc aaa atc aac ggc aaa ctg gtc gct ttg gaa acg 595Arg Cys Ile Gly Ala Lys Ile Asn Gly Lys Leu Val Ala Leu Glu Thr150 155 160 165aaa ctc aaa tcc ggc gat cgt gtt gaa gtc ttt acc tcc aag gac caa 643Lys Leu Lys Ser Gly Asp Arg Val Glu Val Phe Thr Ser Lys Asp Gln

170 175 180aac gct ggc cca agt agg gga tgg caa gaa ttt gtt gtc tca cct cgt 691Asn Ala Gly Pro Ser Arg Gly Trp Gln Glu Phe Val Val Ser Pro Arg

185 190 195gca aag gcc aag att cgc cag tgg ttt gcc aag gaa cga cgc gaa gaa 739Ala Lys Ala Lys Ile Arg Gln Trp Phe Ala Lys Glu Arg Arg Glu Glu

200 205 210tac cta gaa gcc gga cgc gat gcg ctg gca gca gtt att cag cgt ggc 787Tyr Leu Glu Ala GlyArg Asp Ala Leu Ala Ala Val Ile Gln Arg Gly

215 220 225ggc ctg cca atg cac cgc ttg ttc acc gcg tcc tcc atg aag acg gtg 835Gly Leu Pro Met His Arg Leu Phe Thr Ala Ser Ser Met Lys Thr Val230 235 240 245gca aca gag ctg cac tac cca gat gta gat gcg ctc tac aca gcc atc 883Ala Thr Glu Leu His Tyr Pro Asp Val Asp Ala Leu Tyr Thr Ala Ile

250 255 260ggc tcc ggt tct gta tct gcg caa cac gta gtc aac cgt ctc atg gct 931Gly Ser Gly Ser Val Ser Ala Gln His Val Val Asn Arg Leu Met Ala

265 270 275atc ttt ggt gac gaa gaa gat gcc gaa gac gca ttg gtt gca cgc acc 979Ile Phe Gly Asp Glu Glu Asp Ala Glu Asp Ala Leu Val Ala Arg Thr

280 285 290cca ttc agc gag ctg gtc aac tcc cgt gcc acc acg gaa agc agc acc 1027Pro Phe Ser Glu Leu Val Asn Ser Arg Ala Thr Thr Glu Ser Ser Thr

295 300 305ggc atc ctg gtc gaa ggc agc cca gat gtc atg gct aag ctc gct aaa 1075Gly Ile Leu Val Glu Gly Ser Pro Asp Val Met Ala Lys Leu Ala Lys310 315 320 325tgc tgt atg cca gtg cca gga gat gaa atc ttt gga ttc gtc acc cgt 1123Cys Cys Met Pro Val Pro Gly Asp Glu Ile Phe Gly Phe Val Thr Arg

330 335 340ggt ggc ggt gtc tcc gta cac cga aca gac tgc acg aat gtg gaa aag 1171Gly Gly Gly Val Ser Val His Arg Thr Asp Cys Thr Asn Val Glu Lys

345 350 355ctc aaa gaa gag cca gaa cgc att gtc tcc gtc tcc tgg gct tcg gaa 1219Leu Lys Glu Glu Pro Glu Arg Ile Val Ser Val Ser Trp Ala Ser Glu

360365 370ggt caa ggt tca gta 1234Gly Gln Gly Ser Val

375<210>1056<211>378<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1056Val Tyr Ala Ala Ile Gly Val Val His Ser Leu Phe Asn Ala Leu Pro 151015 Gly Arg Phe Lys Asp Tyr Ile Ser Ala Pro Arg Phe Gly Val Tyr Gln

20 25 30Ser Leu His Thr Thr Val Met Gly Pro Gly Gly Lys Pro Leu Glu Val

35 40 45Gln Ala Arg Thr His Asp Met His Tyr Asn Ala Glu Phe Gly Ile Ala

50 55 60Ala His Trp Arg Tyr Lys Glu Thr Lys Gly Ser His Ser Gly Glu Gln 65 70 75 80Ala Glu Val Asp Gln Met Ala Trp Met Arg Gln Leu Leu Asp Trp Gln

85 90 95Lys Glu Ala Ala Asp Pro Asn Glu Phe Leu Asp Ser Leu Arg Tyr Asp

100 105 110Leu Thr Ser Lys Gln Ile Phe Val Phe Thr Pro Lys Gly Asp Val Val

115 120 125Asn Leu Pro Val Asn Ser Thr Pro Val Asp Phe Ala Tyr Ala Val His

130 135 140Thr Glu Val Gly His Arg Cys Ile Gly Ala Lys Ile Asn Gly Lys Leu145 150 155 160Val Ala Leu Glu Thr Lys Leu Lys Ser Gly Asp Arg Val Glu Val Phe

165 170 175Thr Ser Lys Asp Gln Asn Ala Gly Pro Ser Arg Gly Trp Gln Glu Phe

180 185 190Val Val Ser Pro Arg Ala Lys Ala Lys Ile Arg Gln TrpPhe Ala Lys

195 200 205Glu Arg Arg Glu Glu Tyr Leu Glu Ala Gly Arg Asp Ala Leu Ala Ala

210 215 220Val Ile Gln Arg Gly Gly Leu Pro Met His Arg Leu Phe Thr Ala Ser225 230 235 240Ser Met Lys Thr Val Ala Thr Glu Leu His Tyr Pro Asp Val Asp Ala

245 250 255Leu Tyr Thr Ala Ile Gly Ser Gly Ser Val Ser Ala Gln His Val Val

260 265 270Asn Arg Leu Met Ala Ile Phe Gly Asp Glu Glu Asp Ala Glu Asp Ala

275 280 285Leu Val Ala Arg Thr Pro Phe Ser Glu Leu Val Asn Ser Arg Ala Thr

290 295 300Thr Glu Ser Ser Thr Gly Ile Leu Val Glu Gly Ser Pro Asp Val Met305 310 315 320Ala Lys Leu Ala Lys Cys Cys Met Pro Val Pro Gly Asp Glu Ile Phe

325 330 335Gly Phe Val Thr Arg Gly Gly Gly Val Ser Val His Arg Thr Asp Cys

340 345 350Thr Asn Val Glu Lys Leu Lys Glu Glu Pro Glu Arg Ile Val Ser Val

355 360 365Ser Trp Ala Ser Glu Gly Gln Gly Ser Val

370375<210>1057<211>1059<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1036)<223>RXN01940<400>1057ccagaatcaa tcaccgatac agtggcagcc aaagtccagg ctgaagaagc cgctcaagcc 60gccagctaaa tccacaaact gaactaagga gttttaccct atg acc acc aag atc 115

Met Thr Thr Lys Ile

1 5atc ctc gac tgc gat cca gga cac gac gac gct gta gcc atg ctg ctc 163Ile Leu Asp Cys Asp Pro Gly His Asp Asp Ala ValAla Met Leu Leu

10 15 20gca gcc ggc agc cca gaa att gaa ctg ctt gga atc acc acg gtc ggc 211Ala Ala Gly Ser Pro Glu Ile Glu Leu Leu Gly Ile Thr Thr Val Gly

25 30 35ggc aac cag acc ttg gac aag gtc acc cac aat acg cag gtc gta gcc 259Gly Asn Gln Thr Leu Asp Lys Val Thr His Asn Thr Gln Val Val Ala

40 45 50acc atc gct gat atc aat gcg ccc atc tac cgc ggt gtc acc cga cca 307Thr Ile Ala Asp Ile Asn Ala Pro Ile Tyr Arg Gly Val Thr Arg Pro

55 60 65ttg gtg cgc ccc gtt gag gta gcc gaa gat atc cac ggc gat acc ggc 355Leu Val Arg Pro Val Glu Val Ala Glu Asp Ile His Gly Asp Thr Gly 70 75 80 85atg gaa atc cac aag tac gaa ctg cct gaa cca acc aag cag gta gaa 403Met Glu Ile His Lys Tyr Glu Leu Pro Glu Pro Thr Lys Gln Val Glu

90 95 100gac acc cac gcg gtg gat ttc atc atc gat acc atc atg aat aac gag 451Asp Thr His Ala Val Asp Phe Ile Ile Asp Thr Ile Met Asn Asn Glu

105 110 115ccc ggc agc gta gcg ctg gtt ccc acc gga cca ctg acc aac atc gcg 499Pro Gly Ser Val Ala Leu Val Pro Thr Gly Pro Leu Thr Asn Ile Ala

120 125 130ctg gca gtc cgg aaa gaa cca cgc atc gcc gag cga gtc aag gaa gtt 547Leu Ala Val Arg Lys Glu Pro Arg Ile Ala Glu Arg Val Lys Glu Val

135 140 145gtc ctc atg ggc ggg ggc tac cac gta gga aac tgg acc gcc gta gct 595Val Leu Met Gly Gly Gly Tyr His Val Gly Asn Trp Thr Ala Val Ala150 155 160 165gaa ttc aac atc aag atc gac ccc gaa gca gcc cac atc gta ttc aac 643Glu Phe Asn Ile Lys Ile Asp Pro Glu Ala Ala His Ile Val Phe Asn

170 175 180gaa aag tgg cca ctg act atg gtc ggc ctc gac ctt acc cac cag gcg 691Glu Lys Trp Pro Leu Thr Met Val Gly Leu Asp Leu Thr His Gln Ala

185 190 195ctc gca aca cct gag atc gaa gcc aag ttc aac gag ctg ggc acc gac 739Leu Ala Thr Pro Glu Ile Glu Ala Lys Phe Asn Glu Leu Gly Thr Asp

200 205 210gtc gcc gac ttc gtc gtc gcg ctt ttc gac gct ttc cgc aag aat tac 787Val Ala Asp Phe Val Val Ala Leu Phe Asp Ala Phe Arg Lys Asn Tyr

215 220 225cag gac gca cag ggt ttt gat aac cca cca gta cac gac cct tgt gct 835Gln Asp Ala Gln Gly Phe Asp Asn Pro Pro Val His Asp Pro Cys Ala230 235 240 245gtt gca tac ctt gtt gac cca acc gta ttc acc acc cgc aaa gca cca 883Val Ala Tyr Leu Val Asp Pro Thr Val Phe Thr Thr Arg Lys Ala Pro

250 255 260ctc gat gtg gag ctg tac ggc gca ctc acc aca ggc atg acc gtt gct 931Leu Asp Val Glu Leu Tyr Gly Ala Leu Thr Thr Gly Met Thr Val Ala

265 270 275gat ttc cgc gca ccg gct cca gca gat tgc acc acc caa gta gct gtt 979Asp Phe Arg Ala Pro Ala Pro Ala Asp Cys Thr Thr Gln Val Ala Val

280 285 290gac ctg gac ttt gat aaa ttctgg aac atg gtg atc gat gca gta aag 1027Asp Leu Asp Phe Asp Lys Phe Trp Asn Met Val Ile Asp Ala Val Lys

295300305 cgc atc gga tagacctgtt cacaaggttg tta 1059Arg Ile Gly310<210>1058<211>312<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1058Met Thr Thr Lys Ile Ile Leu Asp Cys Asp Pro Gly His Asp Asp Ala 151015 Val Ala Met Leu Leu Ala Ala Gly Ser Pro Glu Ile Glu Leu Leu Gly

20 25 30Ile Thr Thr Val Gly Gly Asn Gln Thr Leu Asp Lys Val Thr His Asn

35 40 45Thr Gln Val Val Ala Thr Ile Ala Asp Ile Asn Ala Pro Ile Tyr Arg

50 55 60Gly Val Thr Arg Pro Leu Val Arg Pro Val Glu Val Ala Glu Asp Ile 65 70 75 80His Gly Asp Thr Gly Met Glu Ile His Lys Tyr Glu Leu Pro Glu Pro

85 90 95Thr Lys Gln Val Glu Asp Thr His Ala Val Asp Phe Ile Ile Asp Thr

100 105 110Ile Met Asn Asn Glu Pro Gly Ser Val Ala Leu Val Pro Thr Gly Pro

115 120 125Leu Thr Asn Ile Ala Leu Ala Val Arg Lys Glu Pro Arg Ile Ala Glu

130 135 140Arg Val Lys Glu Val Val Leu Met Gly Gly Gly Tyr His Val Gly Asn145 150 155 160Trp Thr Ala Val Ala Glu Phe Asn Ile Lys Ile Asp Pro Glu Ala Ala

165 170 175His Ile Val Phe Asn Glu Lys Trp Pro Leu Thr Met Val Gly Leu Asp

180 185 190Leu Thr HisGln Ala Leu Ala Thr Pro Glu Ile Glu Ala Lys Phe Asn

195 200 205Glu Leu Gly Thr Asp Val Ala Asp Phe Val Val Ala Leu Phe Asp Ala

210 215 220Phe Arg Lys Asn Tyr Gln Asp Ala Gln Gly Phe Asp Asn Pro Pro Val225 230 235 240His Asp Pro Cys Ala Val Ala Tyr Leu Val Asp Pro Thr Val Phe Thr

245 250 255Thr Arg Lys Ala Pro Leu Asp Val Glu Leu Tyr Gly Ala Leu Thr Thr

260 265 270Gly Met Thr Val Ala Asp Phe Arg Ala Pro Ala Pro Ala Asp Cys Thr

275 280 285Thr Gln Val Ala Val Asp Leu Asp Phe Asp Lys Phe Trp Asn Met Val

290295300 Ile Asp Ala Val Lys Arg Ile Gly 305310<210>1059<211>602<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) · (579)<223>FRXA01940<400>1059aga gta acg ctt gtt tcc acc ggg cca ctg acc aac atc gcg ctg gca 48Arg Val Thr Leu Val Ser Thr Gly Pro Leu Thr Asn Ile Ala Leu Ala 151015 gtc cgg aaa gaa cca cgc atc gcc gag cga gtc aag gaa gtt gtc ctc 96Val Arg Lys Glu Pro Arg Ile Ala Glu Arg Val Lys Glu Val Val Leu<25>CDS<400>1059aga gta acg ctt gtt tcc acc ggg cca ctg acc aac atc gcg ctg gca

20 25 30atg ggc ggg ggc tac cac gta gga aac tgg acc gcc gta gct gaa ttc 144Met Gly Gly Gly Tyr His Val Gly Asn Trp Thr Ala Val Ala Glu Phe

35 40 45aac atc aag atc gac ccc gaa gca gcc cac atc gta ttc aac gaa aag 192Asn Ile Lys Ile Asp Pro Glu Ala Ala His Ile Val Phe Asn Glu Lys

50 55 60tgg cca ctg act atg gtc ggc ctc gac ctt acc cac cag gcg ctc gca 240Trp Pro Leu Thr Met Val Gly Leu Asp Leu Thr His Gln Ala Leu Ala 65 70 75 80aca cct gag atc gaa gcc aag ttc aac gag ctg ggc acc gac gtc gcc 288Thr Pro Glu Ile Glu Ala Lys Phe Asn Glu Leu Gly Thr Asp Val Ala

85 90 95gac ttc gtc gtc gcg ctt ttc gac gct ttc cgc aag aat tac cag gac 336Asp Phe Val Val Ala Leu Phe Asp Ala Phe Arg Lys Asn Tyr Gln Asp

100 105 110gca cag ggt ttt gat aac cca cca gta cac gac cct tgt gct gtt gca 384Ala Gln Gly Phe Asp Asn Pro Pro Val His Asp Pro Cys Ala Val Ala

115 120 125tac ctt gtt gac cca acc gta ttc acc acc cgc aaa gca cca ctc gat 432Tyr Leu Val Asp Pro Thr Val Phe Thr Thr Arg Lys Ala Pro Leu Asp

130 135 140gtg gag ctg tac ggc gca ctc acc aca ggc atg acc gtt gct gat ttc 480Val Glu Leu Tyr Gly Ala Leu Thr Thr Gly Met Thr Val Ala Asp Phe145 150 155 160cgc gca ccg gct cca gca gat tgc acc acc caa gta gct gtt gac ctg 528Arg Ala Pro Ala Pro Ala Asp Cys Thr Thr Gln Val Ala Val Asp Leu

165 170 175gac ttt gat aaa ttc tgg aac atg gtg atc gat gca gta aag cgc atc 576Asp Phe Asp Lys Phe Trp Asn Met Val Ile Asp Ala Val Lys Arg Ile

180185190 gga tagacctgtt cacaaggttg tta 602Gly<210>1060<211>193<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1060Arg Val Thr Leu Val Ser Thr Gly Pro Leu Thr Asn Ile Ala Leu Ala 151015 Val Arg Lys Glu Pro Arg Ile Ala Glu Arg Val Lys Glu Val Val Leu

20 25 30Met Gly Gly Gly Tyr His Val Gly Asn Trp Thr Ala Val Ala Glu Phe

35 40 45Asn Ile Lys Ile Asp Pro Glu Ala Ala His Ile Val Phe Asn Glu Lys

50 55 60Trp Pro Leu Thr Met Val Gly Leu Asp Leu Thr His Gln Ala Leu Ala 65 70 75 80Thr Pro Glu Ile Glu Ala Lys Phe Asn Glu Leu Gly Thr Asp Val Ala

85 90 95Asp Phe Val Val Ala Leu Phe Asp Ala Phe Arg Lys Asn Tyr Gln Asp

100 105 110Ala Gln Gly Phe Asp Asn Pro Pro Val His Asp Pro Cys Ala Val Ala

115 120 125Tyr Leu Val Asp Pro Thr Val Phe Thr Thr Arg Lys Ala Pro Leu Asp

130 135 140Val Glu Leu Tyr Gly Ala Leu Thr Thr Gly Met Thr Val Ala Asp Phe145 150 155 160Arg Ala Pro Ala Pro Ala Asp Cys Thr Thr Gln Val Ala Val Asp Leu

165 170 175Asp Phe Asp Lys Phe Trp Asn Met Val Ile Asp Ala Val Lys Arg Ile

180185190 Gly<210>1061<211>1026<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<1003><223>RXA02559<400>1061ttagtcctct atggcagcaa gcctgccaga ggagcctatc cagcactaga ccccaactag 60aacccaaccc caaaaccaga aaacactaag ctcgtgagac atg att cct gtt ctc 115

Met Ile Pro Val Leu

1 5atc gac tgc gac acc ggc atc gac gac gcc ctc gcc ctg atc tac ctg 163Ile Asp Cys Asp Thr Gly Ile Asp Asp Ala Leu Ala Leu Ile Tyr Leu

10 15 20gtt gct ttg cat aaa cgt ggt gaa atc caa ctt ttt gga gca acg acc 211Val Ala Leu His Lys Arg Gly Glu Ile Gln Leu Phe Gly Ala Thr Thr

25 30 35acc gca gga aat gtt gat gtg aaa caa acc gcc atc aat acc agg tgg 259Thr Ala Gly Asn Val Asp Val Lys Gln Thr Ala Ile Asn Thr Arg Trp

40 45 50gtg ttg gat cag tgt gga tta gcg gac atc ccg gtc ctc gca gga caa 307Val Leu Asp Gln Cys Gly Leu Ala Asp Ile Pro Val Leu Ala Gly Gln

55 60 65cct gaa cca aag cac gtg ccg cta gtg act act cca gaa aca cac ggc 355Pro Glu Pro Lys His Val Pro Leu Val Thr Thr Pro Glu Thr His Gly 70 75 80 85gac cat ggc ctt ggt tat ata aac cca ggt cac gtc gaa att cca gaa 403Asp His Gly Leu Gly Tyr Ile Asn Pro Gly His Val Glu Ile Pro Glu

90 95 100ggt gac tgg aag cag ctg tgg aaa gaa cac ctc agt aac cca gaa act 451Gly Asp Trp Lys Gln Leu Trp Lys Glu His Leu Ser Asn Pro Glu Thr

105 110 115aag ctg att gtc acc ggg ccc gcc acc aac ctt gcg gaa ttc ggg cca 499Lys Leu Ile Val Thr Gly Pro Ala Thr Asn Leu Ala Glu Phe Gly Pro

120 125 130gtg gaa aac gtc acg ctg atg ggt ggc acc tac ctt tat cca ggc aac 547Val Glu Asn Val Thr Leu Met Gly Gly Thr Tyr Leu Tyr Pro Gly Asn

135 140 145acc act cca acg gca gaa tgg aatacc tgg gtt gat cca cac gga gct 595Thr Thr Pro Thr Ala Glu Trp Asn Thr Trp Val Asp Pro His Gly Ala15 155 160 165aaa gaa gca ttc gcg gca gcc caa aag ccc att acg gtg tgt tcc ttg 643Lys Glu Ala Phe Ala Ala Ala Gln Lys Pro Ile Thr Val Cys Ser Leu

170 175 180ggc gtg acc gag cag ttt acg ctg aac ccg gac atc ctt tct aca ctt 691Gly Val Thr Glu Gln Phe Thr Leu Asn Pro Asp Ile Leu Ser Thr Leu

185 190 195atc aac acg ctt ggc agc caa ccc atc gca gag cat tta cct gag atg 739Ile Asn Thr Leu Gly Ser Gln Pro Ile Ala Glu His Leu Pro Glu Met

200 205 210ctg cgc ttt tac ttt gaa ttt cac gaa gtg cag ggc gaa ggt tac ctt 787Leu Arg Phe Tyr Phe Glu Phe His Glu Val Gln Gly Glu Gly Tyr Leu

215 220 225gct caa att cat gac ctg ctg acc tgc atg att gcc ttg gat aaa atc 835Ala Gln Ile His Asp Leu Leu Thr Cys Met Ile Ala Leu Asp Lys Ile230 235 240 245cca ttt tca ggc cgt gaa gta acc gtg gac gtg gag gct gat tcg ccc 883Pro Phe Ser Gly Arg Glu Val Thr Val Asp Val Glu Ala Asp Ser Pro

250 255 260ttg atg cgt ggc acc act gtt gca gat att cgc gga cat tgg ggc aag 931Leu Met Arg Gly Thr Thr Val Ala Asp Ile Arg Gly His Trp Gly Lys

265 270 275cca gct aac gca ttt ctt gtg gaa acc gca gac att gag gcc gcc cac 979Pro Ala Asn Ala Phe Leu Val Glu Thr Ala Asp Ile Glu Ala Ala His

280 285 290gcg gaa ctt cta aga gca gtg gaa tgaaataatc cggtgctgat gca 1026Ala Glu Leu Leu Arg Ala Val Glu

295300<210>1062<211>301<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1062Met Ile Pro Val Leu Ile Asp Cys Asp Thr Gly Ile Asp Asp Ala Leu 151015 Ala Leu Ile Tyr Leu Val Ala Leu His Lys Arg Gly Glu Ile Gln Leu

20 25 30Phe Gly Ala Thr Thr Thr Ala Gly Asn Val Asp Val Lys Gln Thr Ala

35 40 45Ile Asn Thr Arg Trp Val Leu Asp Gln Cys Gly Leu Ala Asp Ile Pro

50 55 60Val Leu Ala Gly Gln Pro Glu Pro Lys His Val Pro Leu Val Thr Thr65 70 75 80Pro Glu Thr His Gly Asp His Gly Leu Gly Tyr Ile Asn Pro Gly His

85 90 95Val Glu Ile Pro Glu Gly Asp Trp Lys Gln Leu Trp Lys Glu His Leu

100 105 110Ser Asn Pro Glu Thr Lys Leu Ile Val Thr Gly Pro Ala Thr Asn Leu

115 120 125Ala Glu Phe Gly Pro Val Glu Asn Val Thr Leu Met Gly Gly Thr Tyr

130 135 140Leu Tyr Pro Gly Asn Thr Thr Pro Thr Ala Glu Trp Asn Thr Trp Val145 150 155 160Asp Pro His Gly Ala Lys Glu Ala Phe Ala Ala Ala Gln Lys Pro Ile

165 170 175Thr Val Cys Ser Leu Gly Val Thr Glu Gln Phe Thr Leu Asn Pro Asp

180 185 190Ile Leu Ser Thr Leu Ile Asn Thr Leu Gly Ser Gln Pro Ile Ala Glu

195 200 205His Leu Pro Glu Met Leu Arg Phe Tyr Phe Glu Phe His Glu Val Gln

210 215 220Gly Glu Gly Tyr Leu Ala Gln Ile His Asp Leu Leu Thr Cys Met Ile225 230 235 240Ala Leu Asp Lys Ile Pro Phe Ser Gly Arg Glu Val Thr Val Asp Val

245 250 255Glu Ala Asp Ser Pro Leu Met Arg Gly Thr Thr Val Ala Asp Ile Arg

260 265 270Gly His Trp Gly Lys Pro Ala Asn Ala Phe Leu Val Glu Thr Ala Asp

275 280 285Ile Glu Ala Ala His Ala Glu Leu Leu Arg Ala Val Glu

290295300<210>1063<211>1050<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1027)<223>RXA02497<400>1063tcgatgccgc cgctggcgaa gactcgggga aacctaaaaa taccgaagaa gaatttgacc 60gattcacact ttgccaccct agaccgtcta acctttaggt gtg aga tta ggt gta 115

Val Arg Leu Gly Val

1 5tta gat gtg ggc agc aat act gtc cac cta gtt gca gta gac gcg cgt 163Leu Asp Val Gly Ser Asn Thr Val His Leu Val Ala Val Asp Ala Arg

10 15 20ccc ggt gga cac ccc acc ccg atg agc aat tgg cgt acc cca ctg cgc 211Pro Gly Gly His Pro Thr Pro Met Ser Asn Trp Arg Thr Pro Leu Arg

25 30 35ctt gtt gag ctt ctt gat gac tcc ggg gcg atc tcc gaa aag ggc atc 259Leu Val Glu Leu Leu Asp Asp Ser Gly Ala Ile Ser Glu Lys Gly Ile

40 45 50aac aaa ctc acc tca gca gtc ggg gaa gca gca gac cta gcg aaa acg 307Asn Lys Leu Thr Ser Ala Val Gly Glu Ala Ala Asp Leu Ala Lys Thr

55 60 65ctc ggc tgc gct gaa ctg atg cca ttt gct aca tcg gca gtc cgc tcc 355Leu Gly Cys Ala Glu Leu Met Pro Phe Ala Thr Ser Ala Val Arg Ser 70 75 80 85gcc acc aac agc gag gca gtg ctc gac cac gtg gag aag gaa acc ggc 403Ala Thr Asn Ser Glu Ala Val Leu Asp His Val Glu Lys Glu Thr Gly

90 95 100gtc cgc ctg tcc atc ctt tcc ggt gaa gac gaa gca cgc caa act ttc 451Val Arg Leu Ser Ile Leu Ser Gly Glu Asp Glu Ala Arg Gln Thr Phe

105 110 115ctc gca gtt cga cgt tgg tat gga tgg tcc gca ggg cgc ata act aac 499Leu Ala Val Arg Arg Trp Tyr Gly Trp Ser Ala Gly Arg Ile Thr Asn

120 125 130ctc gac atc ggt ggc ggc tcc ctg gaa cta tcc tcc gga acc gac gaa 547Leu Asp Ile Gly Gly Gly Ser Leu Glu Leu Ser Ser Gly Thr Asp Glu

135 140 145tcc cca gac ctc gcg ttc tca ctg gat ctg ggt gcg ggc cgc ttg acc 595Ser Pro Asp Leu Ala Phe Ser Leu Asp Leu Gly Ala Gly Arg Leu Thr150 155 160 165cac aac tgg ttc gac acc gat cca ccg gca cgt aag aaa atc aac ctc 643His Asn Trp Phe Asp Thr Asp Pro Pro Ala Arg Lys Lys Ile Asn Leu

170 175 180ctg cgc gat tat atc gat gcg gaa ctt gca gaa ccc gcc cgc cag atg 691Leu Arg Asp Tyr Ile Asp Ala Glu Leu Ala Glu Pro Ala Arg Gln Met

185 190 195cgc acc cta ggg ccc gcg cgc ctg gca gtg gga aca tcc aaa act ttc 739Arg Thr Leu Gly Pro Ala Arg Leu Ala Val Gly Thr Ser Lys Thr Phe

200 205 210cgc acc ctg gca cga ctg act ggt gct gcg ccc tca tcc gca gga cca 787Arg Thr Leu Ala Arg Leu Thr Gly Ala Ala Pro Ser Ser Ala Gly Pro

215 220 225cac gtc acc cga acc ctc acc gcg ccg ggt ctg cgc cag ctg atc gca 835His Val Thr Arg Thr Leu Thr Ala Pro Gly Leu Arg Gln Leu Ile Ala230 235 240 245ttt atc tca cga atg act gcg gcg gac cgc gct gag ctg gaa ggt atc 883Phe Ile Ser Arg Met Thr Ala Ala Asp Arg Ala Glu Leu Glu Gly Ile

250 255 260agc tcg gat cgg tca cat cag atc gtg gca ggt gcg cta gtt gcg gaa 931Ser Ser Asp Arg Ser His Gln Ile Val Ala Gly Ala Leu Val Ala Glu

265 270 275gct gcg atg cgt gcg ttg gat att gac aag gta gaa att tgt ccg tgg 979Ala Ala Met Arg Ala Leu Asp Ile Asp Lys Val Glu Ile Cys Pro Trp

280 285 290gca ctt cgt gaa ggt gtg atc ctc acc agg atc gac aaa gga ctc gag 1027Ala Leu Arg Glu Gly Val Ile Leu Thr Arg Ile Asp Lys Gly Leu Glu

295300305 taacatttac ccggaaagga gtt 1050<210>1064<211>309<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1064Val Arg Leu Gly Val Leu Asp Val Gly Ser Asn Thr Val His Leu Val 151015 Ala Val Asp Ala Arg Pro Gly Gly His Pro Thr Pro Met Ser Asn Trp

20 25 30Arg Thr Pro Leu Arg Leu Val Glu Leu Leu Asp Asp Ser Gly Ala Ile

35 40 45Ser Glu Lys Gly Ile Asn Lys Leu Thr Ser Ala Val Gly Glu Ala Ala

50 55 60Asp Leu Ala Lys Thr Leu Gly Cys Ala Glu Leu Met Pro Phe Ala Thr 65 70 75 80Ser Ala Val Arg Ser Ala Thr Asn Ser Glu Ala Val Leu Asp His Val

85 90 95Glu Lys Glu Thr Gly Val Arg Leu Ser Ile Leu Ser Gly Glu Asp Glu

100 105 110Ala Arg Gln Thr Phe Leu Ala Val Arg Arg Trp Tyr Gly Trp Ser Ala

115 120 125Gly Arg Ile Thr Asn Leu Asp Ile Gly Gly Gly Ser Leu Glu Leu Ser

130 135 140Ser Gly Thr Asp Glu Ser Pro Asp Leu Ala Phe Ser Leu Asp Leu Gly145 150 155 160Ala Gly Arg Leu Thr His Asn Trp Phe Asp Thr Asp Pro Pro Ala Arg

165 170 175Lys Lys Ile Asn Leu Leu Arg Asp Tyr Ile Asp Ala Glu Leu Ala Glu

180 185 190Pro Ala Arg Gln Met Arg Thr Leu Gly Pro Ala Arg Leu Ala Val Gly

195 200 205Thr Ser Lys Thr Phe Arg Thr Leu Ala Arg Leu Thr Gly Ala Ala Pro

210 215 220Ser Ser Ala Gly Pro His Val Thr Arg Thr Leu Thr Ala Pro Gly Leu225 230 235 240Arg Gln Leu Ile Ala Phe Ile Ser Arg Met Thr Ala Ala Asp Arg Ala

245 250 255Glu Leu Glu Gly Ile Ser Ser Asp Arg Ser His Gln Ile Val Ala Gly

260 265 270Ala Leu Val Ala Glu Ala Ala Met Arg Ala Leu Asp Ile Asp Lys Val

275 280 285Glu Ile Cys Pro Trp Ala Leu Arg Glu Gly Val Ile Leu Thr Arg Ile

290295300 Asp Lys Gly Leu Glu305<210>1065<211>2226<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220>CDS<222>(101). (2203)<223>RXN01079<400>1065accttaaaac ttaatcaatc aatacaaagt tcacacctct tttgaaaggg acattccttt 60gactgcatcg ggaaccaccg tcgtgccacg cggagaccag atg gac ttc cac gct 115

Met Asp Phe His Ala

1 5ctt aac gcg ttg ctc aac ctt tac gat gac aac ggc aag atc cag ttt 163Leu Asn Ala Leu Leu Asn Leu Tyr Asp Asp Asn Gly Lys Ile Gln Phe

10 15 20gag aaa gac cgt gaa gct gca aac cag tac ttc ctg cag cac gtc aac 211Glu Lys Asp Arg Glu Ala Ala Asn Gln Tyr Phe Leu Gln His Val Asn

25 30 35cag aac acc gtc ttc ttc cac aac ctg cag gaa aag atc gac tac ctg 259Gln Asn Thr Val Phe Phe His Asn Leu Gln Glu Lys Ile Asp Tyr Leu

40 45 50gtt gaa aac aag tac tat gac cca atc gtt ctg gac aag tac gac ttc 307Val Glu Asn Lys Tyr Tyr Asp Pro Ile Val Leu Asp Lys Tyr Asp Phe

55 60 65cag ttc atc aag gac ctc ttc aag cgc gca tac gga ttc aag ttc cgc 355Gln Phe Ile Lys Asp Leu Phe Lys Arg Ala Tyr Gly Phe Lys Phe Arg 70 75 80 85ttc cag tcc ttc ctc ggt gca tac aag tac tac act tcc tac acc ctg 403Phe Gln Ser Phe Leu Gly Ala Tyr Lys Tyr Tyr Thr Ser Tyr Thr Leu

90 95 100aag acc ttc gac ggt cgc cgc tac ctc gag cgt ttc gaa gac cgt gtc 451Lys Thr Phe Asp Gly Arg Arg Tyr Leu Glu Arg Phe Glu Asp Arg Val

105 110 115tgc atg gtc gcc ctc acc ctc gct gac ggc gac cgc gca ttg gcc gag 499Cys Met Val Ala Leu Thr Leu Ala Asp Gly Asp Arg Ala Leu Ala Glu

120 125 130aac ctg gtc gat gag atc atg tct ggc cgt ttc caa cca gca acc cca 547Asn Leu Val Asp Glu Ile Met Ser Gly Arg Phe Gln Pro Ala Thr Pro

135 140 145acc ttc ctg aac tcc ggc aag gca cag cgc ggc gag cca gta tcc tgc 595Thr Phe Leu Asn Ser Gly Lys Ala Gln Arg Gly Glu Pro Val Ser Cys150 155 160 165ttc ctc ctg cgt atc gaa gac aac atg gag tcc atc gga cgt tcc atc 643Phe Leu Leu Arg Ile Glu Asp Asn Met Glu Ser Ile Gly Arg Ser Ile

170 175 180aac tct gct ctt cag ctg tcc aag cgt ggc ggt ggc gta gcg ttg ctg 691Asn Ser Ala Leu Gln Leu Ser Lys Arg Gly Gly Gly Val Ala Leu Leu

185 190 195ctg tcc aac ctt cgt gaa gcc ggt gca ccg att aag aag att gaa aac 739Leu Ser Asn Leu Arg Glu Ala Gly Ala Pro Ile Lys Lys Ile Glu Asn

200 205 210cag tct tcc ggt gtt atc cca gtg atg aaa ctt ctg gaa gat gct ttc 787Gln Ser Ser Gly Val Ile Pro Val Met Lys Leu Leu Glu Asp Ala Phe

215 220 225tcc tac gct aac cag ctg ggt gct cgt cag ggt gca ggt gct gtg tac 835Ser Tyr Ala Asn Gln Leu Gly Ala Arg Gln Gly Ala Gly Ala Val Tyr230 235 240 245ctc aac gct cac cac cca gat atc ctg tcc ttc ctg gat acc aag cgt 883Leu Asn Ala His His Pro Asp Ile Leu Ser Phe Leu Asp Thr Lys Arg

250 255 260gag aac gcc gat gag aag atc cgc atc aag acc ctg tcc ctg ggt gtt 931Glu Asn Ala Asp Glu Lys Ile Arg Ile Lys Thr Leu Ser Leu Gly Val

265 270 275gtg att ccg gac atc acc ttc gag ctg gct aag cgc aac gat gac atg 979Val Ile Pro Asp Ile Thr Phe Glu Leu Ala Lys Arg Asn Asp Asp Met

280 285 290tac ctg ttc tcc cca tac gat gtg gag cgc att tac ggc aag cct ttc 1027Tyr Leu Phe Ser Pro Tyr Asp Val Glu Arg Ile Tyr Gly Lys Pro Phe

295 300 305gca gac gtc tca atc acc gag cac tac gac gag atg gtg gat gat gac 1075Ala Asp Val Ser Ile Thr Glu His Tyr Asp Glu Met Val Asp Asp Asp310 315 320 325cgc atc cgc aag acc aag atc aac gcg cgt cag ttc ttc cag acc ctg 1123Arg Ile Arg Lys Thr Lys Ile Asn Ala Arg Gln Phe Phe Gln Thr Leu

330 335 340gca gaa atc cag ttc gag tcc ggt tac cca tac atc atg tat gaa gac 1171Ala Glu Ile Gln Phe Glu Ser Gly Tyr Pro Tyr Ile Met Tyr Glu Asp

345 350 355acc gtg aat gca tcc aac cca atc gaa ggt cgc atc acc cac tca aac 1219Thr Val Asn Ala Ser Asn Pro Ile Glu Gly Arg Ile Thr His Ser Asn

360 365 370ctg tgc tct gag atc ctt cag gtg tcc acc cca tct gaa ttc aac gat 1267Leu Cys Ser Glu Ile Leu Gln Val Ser Thr Pro Ser Glu Phe Asn Asp

375 380 385gac ctg act tac gca gag gtc ggc gaa gac att tct tgt aac ttg ggt 1315Asp Leu Thr Tyr Ala Glu Val Gly Glu Asp Ile Ser Cys Asn Leu Gly390 395 400 405tcc ctc aac gtt gca atg gct atg gat gca cca aac ttt gag aag acc 1363Ser Leu Asn Val Ala Met Ala Met Asp Ala Pro Asn Phe Glu Lys Thr

410 415 420atc gaa acc gaa atc cgc ggc tta act gca gtg cct gag cag acc agc 1411Ile Glu Thr Glu Ile Arg Gly Leu Thr Ala Val Pro Glu Gln Thr Ser

425 430 435atc gat tcc gtg cct tcc atc cgt aag ggc aac gaa gca gct cac gcc 1459Ile Asp Ser Val Pro Ser Ile Arg Lys Gly Asn Glu Ala Ala His Ala

440 445 450atc ggc ctt ggc cag atg aac ctt cac ggc tac ttc ggt cgc gag cac 1507Ile Gly Leu Gly Gln Met Asn Leu His Gly Tyr Phe Gly Arg Glu His

455 460 465atg cac tac ggc tcc gag gaa gcc ctg gac ttc acc aac gca tac ttt 1555Met His Tyr Gly Ser Glu Glu Ala Leu Asp Phe Thr Asn Ala Tyr Phe470 475 480 485gct gcc gtg ctg tac cag tgc ctg cgt gca tcc aac cag atc gct act 1603Ala Ala Val Leu Tyr Gln Cys Leu Arg Ala Ser Asn Gln Ile Ala Thr

490 495 500gag cgt gga gag cgt ttc aag aac ttc gaa aac tcc aag tat gca acc 1651Glu Arg Gly Glu Arg Phe Lys Asn Phe Glu Asn Ser Lys Tyr Ala Thr

505 510 515ggt gag tac ttc gat gat ttc gat gca aac gac ttc gca cca aag tcc 1699Gly Glu Tyr Phe Asp Asp Phe Asp Ala Asn Asp Phe Ala Pro Lys Ser

520 525 530gac aag gtc aag gaa ctc ttt gcc aag tcg aac atc cac acc cca acc 1747Asp Lys Val Lys Glu Leu Phe Ala Lys Ser Asn Ile His Thr Pro Thr

535 540 545gtt gag gac tgg gct gcg ctg aag gcc gac gtg atg gag cac ggt ctg 1795Val Glu Asp Trp Ala Ala Leu Lys Ala Asp Val Met Glu His Gly Leu550 555 560 565ttc aac cgt aac ctg caa gcg gtt cca cca acc ggt tcg atc tcc tac 1843Phe Asn Arg Asn Leu Gln Ala Val Pro Pro Thr Gly Ser Ile Ser Tyr

570 575 580atc aac aac tcc acc tcg tcg atc cac cca atc gca tcc aag att gag 1891Ile Asn Asn Ser Thr Ser Ser Ile His Pro Ile Ala Ser Lys Ile Glu

585 590 595atc cgc aag gaa ggc aag atc ggc cgc gtt tac tac cca gct cca cac 1939Ile Arg Lys Glu Gly Lys Ile Gly Arg Val Tyr Tyr Pro Ala Pro His

600 605 610atg gac aat gac aac ctt gag tac ttc gag gac gcc tac gaa atc ggc 1987Met Asp Asn Asp Asn Leu Glu Tyr Phe Glu Asp Ala Tyr Glu Ile Gly

615 620 625tac gag aag atc att gac acc tac gct gtg gca acc aag tac gtt gac 2035Tyr Glu Lys Ile Ile Asp Thr Tyr Ala Val Ala Thr Lys Tyr Val Asp630 635 640 645cag ggc ctg tca ctg acc ttg ttc ttc aag gac act gcc acc acc cgt 2083Gln Gly Leu Ser Leu Thr Leu Phe Phe Lys Asp Thr Ala Thr Thr Arg

650 655 660gac atc aac cgt gcg cag atc tac gca tgg cgc aag ggc atc aag acc 2131Asp Ile Asn Arg Ala Gln Ile Tyr Ala Trp Arg Lys Gly Ile Lys Thr

665 670 675ttg tac tac att cgc ctg cgc cag gtt gct ctg gaa ggc act gaa gtt 2179Leu Tyr Tyr Ile Arg Leu Arg Gln Val Ala Leu Glu Gly Thr Glu Val

680 685 690gac ggc tgc gtc agc tgc atg ctg taaaagcact taaaaatatc ccc 2226Asp Gly Cys Val Ser Cys Met Leu

695700<210>1066<211>701<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1066Met Asp Phe His Ala Leu Asn Ala Leu Leu Asn Leu Tyr Asp Asp Asn 151015 Gly Lys Ile Gln Phe Glu Lys Asp Arg Glu Ala Ala Asn Gln Tyr Phe

20 25 30Leu Gln His Val Asn Gln Asn Thr Val Phe Phe His Asn Leu Gln Glu

35 40 45Lys Ile Asp Tyr Leu Val Glu Asn Lys Tyr Tyr Asp Pro Ile Val Leu

50 55 60Asp Lys Tyr Asp Phe Gln Phe Ile Lys Asp Leu Phe Lys Arg Ala Tyr 65 70 75 80Gly Phe Lys Phe Arg Phe Gln Ser Phe Leu Gly Ala Tyr Lys Tyr Tyr

85 90 95Thr Ser Tyr Thr Leu Lys Thr Phe Asp Gly Arg Arg Tyr Leu Glu Arg

100 105 110Phe Glu Asp Arg Val Cys Met Val Ala Leu Thr Leu Ala Asp Gly Asp

115 120 125Arg Ala Leu Ala Glu Asn Leu Val Asp Glu Ile Met Ser Gly Arg Phe

130 135 140Gln Pro Ala Thr Pro Thr Phe Leu Asn Ser Gly Lys Ala Gln Arg Gly145 150 155 160Glu Pro Val Ser Cys Phe Leu Leu Arg Ile Glu Asp Asn Met Glu Ser

165 170 175Ile Gly Arg Ser Ile Asn Ser Ala Leu Gln Leu Ser Lys Arg Gly Gly

180 185 190Gly Val Ala Leu Leu Leu Ser Asn Leu Arg Glu Ala Gly Ala Pro Ile

195 200 205Lys Lys Ile Glu Asn Gln Ser Ser Gly Val Ile Pro Val Met Lys Leu

210 215220Leu Glu Asp Ala Phe Ser Tyr Ala Asn Gln Leu Gly Ala Arg Gln Gly225 230 235 240Ala Gly Ala Val Tyr Leu Asn Ala His His Pro Asp Ile Leu Ser Phe

245 250 255Leu Asp Thr Lys Arg Glu Asn Ala Asp Glu Lys Ile Arg Ile Lys Thr

260 265 270Leu Ser Leu Gly Val Val Ile Pro Asp Ile Thr Phe Glu Leu Ala Lys

275 280 285Arg Asn Asp Asp Met Tyr Leu Phe Ser Pro Tyr Asp Val Glu Arg Ile

290 295 300Tyr Gly Lys Pro Phe Ala Asp Val Ser Ile Thr Glu His Tyr Asp Glu305 310 315 320Met Val Asp Asp Asp Arg Ile Arg Lys Thr Lys Ile Asn Ala Arg Gln

325 330 335Phe Phe Gln Thr Leu Ala Glu Ile Gln Phe Glu Ser Gly Tyr Pro Tyr

340 345 350Ile Met Tyr Glu Asp Thr Val Asn Ala Ser Asn Pro Ile Glu Gly Arg

355 360 365Ile Thr His Ser Asn Leu Cys Ser Glu Ile Leu Gln Val Ser Thr Pro

370 375 380Ser Glu Phe Asn Asp Asp Leu Thr Tyr Ala Glu Val Gly Glu Asp Ile385 390 395 400Ser Cys Asn Leu Gly Ser Leu Asn Val Ala Met Ala Met Asp Ala Pro

405 410 415Asn Phe Glu Lys Thr Ile Glu Thr Glu Ile Arg Gly Leu Thr Ala Val

420 425 430Pro Glu Gln Thr Ser Ile Asp Ser Val Pro Ser Ile Arg Lys Gly Asn

435440 445Glu Ala Ala His Ala Ile Gly Leu Gly Gln Met Asn Leu His Gly Tyr

450 455 460Phe Gly Arg Glu His Met His Tyr Gly Ser Glu Glu Ala Leu Asp Phe465 470 475 480Thr Asn Ala Tyr Phe Ala Ala Val Leu Tyr Gln Cys Leu Arg Ala Ser

485 490 495Asn Gln Ile Ala Thr Glu Arg Gly Glu Arg Phe Lys Asn Phe Glu Asn

500 505 510Ser Lys Tyr Ala Thr Gly Glu Tyr Phe Asp Asp Phe Asp Ala Asn Asp

515 520 525Phe Ala Pro Lys Ser Asp Lys Val Lys Glu Leu Phe Ala Lys Ser Asn

530 535 540Ile His Thr Pro Thr Val Glu Asp Trp Ala Ala Leu Lys Ala Asp Val545 550 555 560Met Glu His Gly Leu Phe Asn Arg Asn Leu Gln Ala Val Pro Pro Thr

565 570 575Gly Ser Ile Ser Tyr Ile Asn Asn Ser Thr Ser Ser Ile His Pro Ile

580 585 590Ala Ser Lys Ile Glu Ile Arg Lys Glu Gly Lys Ile Gly Arg Val Tyr

595 600 605Tyr Pro Ala Pro His Met Asp Asn Asp Asn Leu Glu Tyr Phe Glu Asp

610 615 620Ala Tyr Glu Ile Gly Tyr Glu Lys Ile Ile Asp Thr Tyr Ala Val Ala625 630 635 640Thr Lys Tyr Val Asp Gln Gly Leu Ser Leu Thr Leu Phe Phe Lys Asp

645 650 655Thr Ala Thr Thr Arg Asp Ile Asn Arg Ala Gln Ile Tyr Ala Trp Arg

660 665 670Lys Gly Ile Lys Thr Leu Tyr Tyr Ile Arg Leu Arg Gln Val Ala Leu

675 680 685Glu Gly Thr Glu Val Asp Gly Cys Val Ser Cys Met Leu

690695700<210>1067<211>790<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<790>FRXA01079<400>1067accttaaaac ttaatcaatc aatacaaagt tcacacctct tttgaaaggg acattccttt 60gactgcatcg ggaaccaccg tcgtgccacg cggagaccag atg gac ttc cac gct 115

Met Asp Phe His Ala

1 5ctt aac gcg ttg ctc aac ctt tac gat gac aac ggc aag atc cag ttt 163Leu Asn Ala Leu Leu Asn Leu Tyr Asp Asp Asn Gly Lys Ile Gln Phe

10 15 20gag aaa gac cgt gaa gct gca aac cag tac ttc ctg cag cac gtc aac 211Glu Lys Asp Arg Glu Ala Ala Asn Gln Tyr Phe Leu Gln His Val Asn

25 30 35cag aac acc gtc ttc ttc cac aac ctg cag gaa aag atc gac tac ctg 259Gln Asn Thr Val Phe Phe His Asn Leu Gln Glu Lys Ile Asp Tyr Leu

40 45 50gtt gaa aac aag tac tat gac cca atc gtt ctg gac aag tac gac ttc 307Val Glu Asn Lys Tyr Tyr Asp Pro Ile Val Leu Asp Lys Tyr Asp Phe

55 60 65cag ttc atc aag gac ctc ttc aag cgc gca tac gga ttc aag ttc cgc 355Gln Phe Ile Lys Asp Leu Phe Lys Arg Ala Tyr Gly Phe Lys Phe Arg

75 80 85ttc cag tcc ttc ctc ggt gca tac aag tac tac act tcc tac acc ctg 403Phe Gln Ser Phe Leu GlyAla Tyr Lys Tyr Tyr Thr Ser Tyr Thr Leu

90 95 100aag acc ttc gac ggt cgc cgc tac ctc gag cgt ttc gaa gac cgt gtc 451Lys Thr Phe Asp Gly Arg Arg Tyr Leu Glu Arg Phe Glu Asp Arg Val

105 110 115tgc atg gtc gcc ctc acc ctc gct gac ggc gac cgc gca ttg gcc gag 499Cys Met Val Ala Leu Thr Leu Ala Asp Gly Asp Arg Ala Leu Ala Glu

120 125 130aac ctg gtc gat gag atc atg tct ggc cgt ttc caa cca gca acc cca 547Asn Leu Val Asp Glu Ile Met Ser Gly Arg Phe Gln Pro Ala Thr Pro

135 140 145acc ttc ctg aac tcc ggc aag gca cag cgc ggc gag cca gta tcc tgc 595Thr Phe Leu Asn Ser Gly Lys Ala Gln Arg Gly Glu Pro Val Ser Cys150 155 160 165ttc ctc ctg cgt atc gaa gac aac atg gag tcc atc gga cgt tcc atc 643Phe Leu Leu Arg Ile Glu Asp Asn Met Glu Ser Ile Gly Arg Ser Ile

170 175 180aac tct gct ctt cag ctg tcc aag cgt ggc ggt ggc gta gcg ttg ctg 691Asn Ser Ala Leu Gln Leu Ser Lys Arg Gly Gly Gly Val Ala Leu Leu

185 190 195ctg tcc aac ctt cgt gaa gcc ggt gca ccg att aag aag att gaa atc 739Leu Ser Asn Leu Arg Glu Ala Gly Ala Pro Ile Lys Lys Ile Glu Ile

200 205 210cag tct tcc ggt gtt atc cca gtg atg aaa ctt ctg gaa gat gct ttc 787Gln Ser Ser Gly Val Ile Pro Val Met Lys Leu Leu Glu Asp Ala Phe

215220225 tc 790Ser230<210>1068<211>230<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1068Met Asp Phe His Ala Leu Asn Ala Leu Leu Asn Leu Tyr Asp AspAsn 151015 Gly Lys Ile Gln Phe Glu Lys Asp Arg Glu Ala Ala Asn Gln Tyr Phe

20 25 30Leu Gln His Val Asn Gln Asn Thr Val Phe Phe His Asn Leu Gln Glu

35 40 45Lys Ile Asp Tyr Leu Val Glu Asn Lys Tyr Tyr Asp Pro Ile Val Leu

50 55 60Asp Lys Tyr Asp Phe Gln Phe Ile Lys Asp Leu Phe Lys Arg Ala Tyr 65 70 75 80Gly Phe Lys Phe Arg Phe Gln Ser Phe Leu Gly Ala Tyr Lys Tyr Tyr

85 90 95Thr Ser Tyr Thr Leu Lys Thr Phe Asp Gly Arg Arg Tyr Leu Glu Arg

100 105 110Phe Glu Asp Arg Val Cys Met Val Ala Leu Thr Leu Ala Asp Gly Asp

115 120 125Arg Ala Leu Ala Glu Asn Leu Val Asp Glu Ile Met Ser Gly Arg Phe

130 135 140Gln Pro Ala Thr Pro Thr Phe Leu Asn Ser Gly Lys Ala Gln Arg Gly145 150 155 160Glu Pro Val Ser Cys Phe Leu Leu Arg Ile Glu Asp Asn Met Glu Ser

165 170 175Ile Gly Arg Ser Ile Asn Ser Ala Leu Gln Leu Ser Lys Arg Gly Gly

180 185 190Gly Val Ala Leu Leu Leu Ser Asn Leu Arg Glu Ala Gly Ala Pro Ile

195 200 205Lys Lys Ile Glu Ile Gln Ser Ser Gly Val Ile Pro Val Met Lys Leu

210215220 Leu Glu Asp Ala Phe Ser 225230<210>1069<211>1364<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) · (1341)<223>FRXA01084<220><221>misc _ failure<222>504, 535<223>n ═ a, t, c, or g<220><221>VARIANT<222>168<223>Xaa ═ Ile or Met<220><221>VARIANT<222>179<223>Xaa ═ Ser, Pro, Thr, or Ala<400>1069tcc ttt ctg gat acc aag cgc gag aac gcc gat gag aag atc cgc atc 48Ser Phe Leu Asp Thr Lys Arg Glu Asn Ala Asp Glu Lys Ile Arg Ile 151015 aag acc ctg tcc ctg ggt gtt gtg att ccg gac atc acc ttc gag ctg 96Lys Thr Leu Ser Leu Gly Val Val Ile Pro Asp Ile Thr Phe Glu Leu.

20 25 30gct aag cgc aac gat gac atg tac ctg ttc tcc cca tac gat gtg gag 144Ala Lys Arg Asn Asp Asp Met Tyr Leu Phe Ser Pro Tyr Asp Val Glu

35 40 45cgc att tac ggc aag cct ttc gca gac gtc tca atc acc gag cac tac 192Arg Ile Tyr Gly Lys Pro Phe Ala Asp Val Ser Ile Thr Glu His Tyr

50 55 60gac gag atg gtg gat gat gac cgc atc cgc aag acc aag atc aac gcg 240Asp Glu Met Val Asp Asp Asp Arg Ile Arg Lys Thr Lys Ile Asn Ala 65 70 75 80cgt cag ttc ttc cag acc ctg gca gaa atc cag ttc gag tcc ggt tac 288Arg Gln Phe Phe Gln Thr Leu Ala Glu Ile Gln Phe Glu Ser Gly Tyr

85 90 95cca tac atc atg tat gaa gac acc gtg aat gca tcc aac cca atc gaa 336Pro Tyr Ile Met Tyr Glu Asp Thr Val Asn Ala Ser Asn Pro Ile Glu

100 105 110ggt cgc atc acc cac tca aac ctg tgc tct gag atc ctt cag gtg tcc 384Gly Arg Ile Thr His Ser Asn Leu Cys Ser Glu Ile Leu Gln Val Ser

115 120 125acc cca tct gaa ttc aac gat gac ctg act tac gca gag gtc ggc gaa 432Thr Pro Ser Glu Phe Asn Asp Asp Leu Thr Tyr Ala Glu Val Gly Glu

130 135 140gac att tct tgt aac ttg ggt tcc ctc aac gtt gca atg gct atg gat 480Asp Ile Ser Cys Asn Leu Gly Ser Leu Asn Val Ala Met Ala Met Asp145 150 155 160gca cca aac ttt gag aag acc atn gaa acc gaa atc cgc ggc tta act 528Ala Pro Asn Phe Glu Lys Thr Xaa Glu Thr Glu Ile Arg Gly Leu Thr

165 170 175gca gtg nct gag cag acc agc atc gat tcc gtg cct tcc atc cgt aag 576Ala Val Xaa Glu Gln Thr Ser Ile Asp Ser Val Pro Ser Ile Arg Lys

180 185 190ggc aac gaa gca gct cac gcc atc ggc ctt ggc cag atg aac ctt cac 624Gly Asn Glu Ala Ala His Ala Ile Gly Leu Gly Gln Met Asn Leu His

195 200 205ggc tac ttc ggt cgc gag cac atg cac tac ggc tcc gag gaa gcc ctg 672Gly Tyr Phe Gly Arg Glu His Met His Tyr Gly Ser Glu Glu Ala Leu

210 215 220gac ttc acc aac gca tac ttt gct gcc gtg ctg tac cag tgc ctg cgt 720Asp Phe Thr Asn Ala Tyr Phe Ala Ala Val Leu Tyr Gln Cys Leu Arg225 230 235 240gca tcc aac cag atc gct act gag cgt gga gag cgt ttc aag aac ttc 768Ala Ser Asn Gln Ile Ala Thr Glu Arg Gly Glu Arg Phe Lys Asn Phe

245 250 255gaa aac tcc aag tat gca acc ggt gag tac ttc gat gat ttc gat gca 816Glu Asn Ser Lys Tyr Ala Thr Gly Glu Tyr Phe Asp Asp Phe Asp Ala

260 265 270aac gac ttc gca cca aag tcc gac aag gtc aag gaa ctc ttt gcc aag 864Asn Asp Phe Ala Pro Lys Ser Asp Lys Val Lys Glu Leu Phe Ala Lys

275 280 285tcg aac atc cac acc cca acc gtt gag gac tgg gct gcg ctg aag gcc 912Ser Asn Ile His Thr Pro Thr Val Glu Asp Trp Ala Ala Leu Lys Ala

290 295 300gac gtg atg gag cac ggt ctg ttc aac cgt aac ctg caa gcg gtt cca 960Asp Val Met Glu His Gly Leu Phe Asn Arg Asn Leu Gln Ala Val Pro305 310 315 320cca acc ggt tcg atc tcc tac atc aac aac tcc acc tcg tcg atc cac 1008Pro Thr Gly Ser Ile Ser Tyr Ile Asn Asn Ser Thr Ser Ser Ile His

325 330 335cca atc gca tcc aag att gag atc cgc aag gaa ggc aag atc ggc cgc 1056Pro Ile Ala Ser Lys Ile Glu Ile Arg Lys Glu Gly Lys Ile Gly Arg

340 345 350gtt tac tac cca gct cca cac atg gac aat gac aac ctt gag tac ttc 1104Val Tyr Tyr Pro Ala Pro His Met Asp Asn Asp Asn Leu Glu Tyr Phe

355 360 365gag gac gcc tac gaa atc ggc tac gag aag atc att gac acc tac gct 1152Glu Asp Ala Tyr Glu Ile Gly Tyr Glu Lys Ile Ile Asp Thr Tyr Ala

370 375 380gtg gca acc aag tac gtt gac cag ggc ctg tca ctg acc ttg ttc ttc 1200Val Ala Thr Lys Tyr Val Asp Gln Gly Leu Ser Leu Thr Leu Phe Phe385 390 395 400aag gac act gcc acc acc cgt gac atc aac cgt gcg cag atc tac gca 1248Lys Asp Thr Ala Thr Thr Arg Asp Ile Asn Arg Ala Gln Ile Tyr Ala

405 410 415tgg cgc aag ggc atc aag acc ttg tac tac att cgc ctg cgc cag gtt 1296Trp Arg Lys Gly Ile Lys Thr Leu Tyr Tyr Ile Arg Leu Arg Gln Val

420 425 430gctctg gaa ggc act gaa gtt gac ggc tgc gtc agc tgc atg ctg 1341Ala Leu Glu Gly Thr Glu Val Asp Gly Cys Val Ser Cys Met Leu

435440445 taaaagcact taaaaatatc ccc 1364<210>1070<211>447<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>VARIANT<222>168<223>Xaa ═ Ile or Met<220><221>VARIANT<222>179<223>Xaa ═ Ser, Pro, Thr, or Ala<400>1070Ser Phe Leu Asp Thr Lys Arg Glu Asn Ala Asp Glu Lys Ile Arg Ile 151015 Lys Thr Leu Ser Leu Gly Val Val Ile Pro Asp Ile Thr Phe Glu Leu

20 25 30Ala Lys Arg Asn Asp Asp Met Tyr Leu Phe Ser Pro Tyr Asp Val Glu

35 40 45Arg Ile Tyr Gly Lys Pro Phe Ala Asp Val Ser Ile Thr Glu His Tyr

50 55 60Asp Glu Met Val Asp Asp Asp Arg Ile Arg Lys Thr Lys Ile Asn Ala 65 70 75 80Arg Gln Phe Phe Gln Thr Leu Ala Glu Ile Gln Phe Glu Ser Gly Tyr

85 90 95Pro Tyr Ile Met Tyr Glu Asp Thr Val Asn Ala Ser Asn Pro Ile Glu

100 105 110Gly Arg Ile Thr His Ser Asn Leu Cys Ser Glu Ile Leu Gln Val Ser

115 120 125Thr Pro Ser Glu Phe Asn Asp Asp Leu Thr Tyr Ala Glu Val Gly Glu

130 135 140Asp Ile Ser Cys Asn Leu Gly Ser Leu Asn Val Ala Met Ala Met Asp145 150 155 160Ala Pro Asn Phe Glu Lys Thr Xaa Glu Thr Glu Ile Arg Gly Leu Thr

165 170 175AlaVal Xaa Glu Gln Thr Ser Ile Asp Ser Val Pro Ser Ile Arg Lys

180 185 190Gly Asn Glu Ala Ala His Ala Ile Gly Leu Gly Gln Met Asn Leu His

195 200 205Gly Tyr Phe Gly Arg Glu His Met His Tyr Gly Ser Glu Glu Ala Leu

210 215 220Asp Phe Thr Asn Ala Tyr Phe Ala Ala Val Leu Tyr Gln Cys Leu Arg225 230 235 240Ala Ser Asn Gln Ile Ala Thr Glu Arg Gly Glu Arg Phe Lys Asn Phe

245 250 255Glu Asn Ser Lys Tyr Ala Thr Gly Glu Tyr Phe Asp Asp Phe Asp Ala

260 265 270Asn Asp Phe Ala Pro Lys Ser Asp Lys Val Lys Glu Leu Phe Ala Lys

275 280 285Ser Asn Ile His Thr Pro Thr Val Glu Asp Trp Ala Ala Leu Lys Ala

290 295 300Asp Val Met Glu His Gly Leu Phe Asn Arg Asn Leu Gln Ala Val Pro305 310 315 320Pro Thr Gly Ser Ile Ser Tyr Ile Asn Asn Ser Thr Ser Ser Ile His

325 330 335Pro Ile Ala Ser Lys Ile Glu Ile Arg Lys Glu Gly Lys Ile Gly Arg

340 345 350Val Tyr Tyr Pro Ala Pro His Met Asp Asn Asp Asn Leu Glu Tyr Phe

355 360 365Glu Asp Ala Tyr Glu Ile Gly Tyr Glu Lys Ile Ile Asp Thr Tyr Ala

370 375 380Val Ala Thr Lys Tyr Val Asp Gln Gly Leu Ser Leu Thr Leu Phe Phe385 390 395400Lys Asp Thr Ala Thr Thr Arg Asp Ile Asn Arg Ala Gln Ile Tyr Ala

405 410 415Trp Arg Lys Gly Ile Lys Thr Leu Tyr Tyr Ile Arg Leu Arg Gln Val

420 425 430Ala Leu Glu Gly Thr Glu Val Asp Gly Cys Val Ser Cys Met Leu

435440445<210>1071<211>1125<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<1102)<223>RXN01920<400>1071cttctgaagg gcttcggttg gggtaagctg gcgatctgaa atcgcgctgc attgtggcgt 60cgaaaagcaa aaaaatttgt agaagggaag agcgcaccta atg gct gct gat tct 115

Met Ala Ala Asp Ser

1 5gat ctc agt gtt cac gat gct tac tta aag gag cat gtt gca cct gta 163Asp Leu Ser Val His Asp Ala Tyr Leu Lys Glu His Val Ala Pro Val

10 15 20aag gcg atc aac tgg aac tcc atc cca gat tcc aaa gat ctt gaa gtc 211Lys Ala Ile Asn Trp Asn Ser Ile Pro Asp Ser Lys Asp Leu Glu Val

25 30 35tgg gat cgt ctg acc ggt aac ttc tgg ctc cca gaa aag gtc cca gta 259Trp Asp Arg Leu Thr Gly Asn Phe Trp Leu Pro Glu Lys Val Pro Val

40 45 50tcc aac gac atc aag agc tgg gga acc ctc aac gag gtt gaa aaa gcc 307Ser Asn Asp Ile Lys Ser Trp Gly Thr Leu Asn Glu Val Glu Lys Ala

55 60 65gca acc atg cgc gtg ttc acc gga ctt acc ctg ctg gac acc att cag 355Ala Thr Met Arg Val Phe Thr Gly Leu Thr Leu Leu Asp Thr Ile Gln 70 75 8085ggc act gtc ggc gca atc tcc ctg ctt cca gac gca gat tca ctg cac 403Gly Thr Val Gly Ala Ile Ser Leu Leu Pro Asp Ala Asp Ser Leu His

90 95 100gaa gaa gcg gtg cta acc aac att gcg ttc atg gaa tcc gtg cac gca 451Glu Glu Ala Val Leu Thr Asn Ile Ala Phe Met Glu Ser Val His Ala

105 110 115aag agt tac tcc aac atc ttc atg act ctg gcc tcc acc gcg gaa atc 499Lys Ser Tyr Ser Asn Ile Phe Met Thr Leu Ala Ser Thr Ala Glu Ile

120 125 130aac gat gcg ttc cgt tgg tct gag gaa aat gaa aac ctg cag cgc aag 547Asn Asp Ala Phe Arg Trp Ser Glu Glu Asn Glu Asn Leu Gln Arg Lys

135 140 145gca aag atc atc ctg tct tac tat gag ggc gat gat cca cta aag cgc 595Ala Lys Ile Ile Leu Ser Tyr Tyr Glu Gly Asp Asp Pro Leu Lys Arg150 155 160 165aag atc gcc tcc gtg atc ctg gag tcc ttc ctg ttc tac tcc ggc ttc 643Lys Ile Ala Ser Val Ile Leu Glu Ser Phe Leu Phe Tyr Ser Gly Phe

170 175 180tac ctc cca atg tat tgg tcc agc cac tcc aag ctg gcc aac acc gcc 691Tyr Leu Pro Met Tyr Trp Ser Ser His Ser Lys Leu Ala Asn Thr Ala

185 190 195gac gtg atc cgc ctg atc atc cgc gat gag gca gtg cac ggc tac tac 739Asp Val Ile Arg Leu Ile Ile Arg Asp Glu Ala Val His Gly Tyr Tyr

200 205 210att ggc tac aag tat caa aag gct gtc gcg aag gag act cca gag cgt 787Ile Gly Tyr Lys Tyr Gln Lys Ala Val Ala Lys Glu Thr Pro Glu Arg

215 220 225cag gaa gag ctg aag gag tac acc ttc gat ctg ctc tac gat ctt tac 835Gln Glu Glu Leu Lys Glu Tyr Thr Phe Asp Leu Leu Tyr Asp Leu Tyr230 235 240 245gat aac gaa act cag tac tcc gaa gat ctc tac gac gat ctt gga tgg 883Asp Asn Glu Thr Gln Tyr Ser Glu Asp Leu Tyr Asp Asp Leu Gly Trp

250 255 260acc gag gat gtt aag cga ttc ctt cgc tac aac gcc aac aag gcc ctc 931Thr Glu Asp Val Lys Arg Phe Leu Arg Tyr Asn Ala Asn Lys Ala Leu

265 270 275aac aac ctt ggc tac gaa gga ctc ttc cca gcg gat gaa acc aag gtg 979Asn Asn Leu Gly Tyr Glu Gly Leu Phe Pro Ala Asp Glu Thr Lys Val

280 285 290tcc cca aac atc ttg tct gcg ctg tca cca aac gct gat gag aac cac 1027Ser Pro Asn Ile Leu Ser Ala Leu Ser Pro Asn Ala Asp Glu Asn His

295 300 305gac ttc ttc tcc ggc tcc ggt tcc tct tac gtt att ggt aag gca gaa 1075Asp Phe Phe Ser Gly Ser Gly Ser Ser Tyr Val Ile Gly Lys Ala Glu310 315 320 325aac acc gag gat gat gac tgg gac ttc taacttttaa aaagctgaag 1122Asn Thr Glu Asp Asp Asp Trp Asp Phe

330cgc 1125<210>1072<211>334<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1072Met Ala Ala Asp Ser Asp Leu Ser Val His Asp Ala Tyr Leu Lys Glu 151015 His Val Ala Pro Val Lys Ala Ile Asn Trp Asn Ser Ile Pro Asp Ser

20 25 30Lys Asp Leu Glu Val Trp Asp Arg Leu Thr Gly Asn Phe Trp Leu Pro

35 40 45Glu Lys Val Pro Val Ser Asn Asp Ile Lys Ser Trp Gly Thr Leu Asn

50 55 60Glu Val Glu Lys AlaAla Thr Met Arg Val Phe Thr Gly Leu Thr Leu 65 70 75 80Leu Asp Thr Ile Gln Gly Thr Val Gly Ala Ile Ser Leu Leu Pro Asp

85 90 95Ala Asp Ser Leu His Glu Glu Ala Val Leu Thr Asn Ile Ala Phe Met

100 105 110Glu Ser Val His Ala Lys Ser Tyr Ser Asn Ile Phe Met Thr Leu Ala

115 120 125Ser Thr Ala Glu Ile Asn Asp Ala Phe Arg Trp Ser Glu Glu Asn Glu

130 135 140Asn Leu Gln Arg Lys Ala Lys Ile Ile Leu Ser Tyr Tyr Glu Gly Asp145 150 155 160Asp Pro Leu Lys Arg Lys Ile Ala Ser Val Ile Leu Glu Ser Phe Leu

165 170 175Phe Tyr Ser Gly Phe Tyr Leu Pro Met Tyr Trp Ser Ser His Ser Lys

180 185 190Leu Ala Asn Thr Ala Asp Val Ile Arg Leu Ile Ile Arg Asp Glu Ala

195 200 205Val His Gly Tyr Tyr Ile Gly Tyr Lys Tyr Gln Lys Ala Val Ala Lys

210 215 220Glu Thr Pro Glu Arg Gln Glu Glu Leu Lys Glu Tyr Thr Phe Asp Leu225 230 235 240Leu Tyr Asp Leu Tyr Asp Asn Glu Thr Gln Tyr Ser Glu Asp Leu Tyr

245 250 255Asp Asp Leu Gly Trp Thr Glu Asp Val Lys Arg Phe Leu Arg Tyr Asn

260 265 270Ala Asn Lys Ala Leu Asn Asn Leu Gly Tyr Glu Gly Leu Phe Pro Ala

275 280 285Asp GluThr Lys Val Ser Pro Asn Ile Leu Ser Ala Leu Ser Pro Asn

290 295 300Ala Asp Glu Asn His Asp Phe Phe Ser Gly Ser Gly Ser Ser Tyr Val305 310 315 320Ile Gly Lys Ala Glu Asn Thr Glu Asp Asp Asp Trp Asp Phe

325330<210>1073<211>437<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) } (414)<223>FRXA01920<400>1073gcc gac gtg atc cgc ctg atc atc cgc gat gag gca gtg cac ggc tac 48Ala Asp Val Ile Arg Leu Ile Ile Arg Asp Glu Ala Val His Gly Tyr 151015 tac att ggc tac aag tat caa aag gct gtc gcg aag gag act cca gag 96Tyr Ile Gly Tyr Lys Tyr Gln Lys Ala Val Ala Lys Glu Thr Pro Glu

20 25 30cgt cag gaa gag ctg aag gag tac acc ttc gat ctg ctc tac gat ctt 144Arg Gln Glu Glu Leu Lys Glu Tyr Thr Phe Asp Leu Leu Tyr Asp Leu

35 40 45tac gat aac gaa act cag tac tcc gaa gat ctc tac gac gat ctt gga 192Tyr Asp Asn Glu Thr Gln Tyr Ser Glu Asp Leu Tyr Asp Asp Leu Gly

50 55 60tgg acc gag gat gtt aag cga ttc ctt cgc tac aac gcc aac aag gcc 240Trp Thr Glu Asp Val Lys Arg Phe Leu Arg Tyr Asn Ala Asn Lys Ala 65 70 75 80ctc aac aac ctt ggc tac gaa gga ctc ttc cca gcg gat gaa acc aag 288Leu Asn Asn Leu Gly Tyr Glu Gly Leu Phe Pro Ala Asp Glu Thr Lys

85 90 95gtg tcc cca aac atc ttg tct gcg ctg tca cca aac gct gat gag aac 336Val Ser Pro Asn Ile Leu Ser Ala Leu Ser Pro Asn Ala Asp Glu Asn

100 105 110cac gac ttc ttc tcc ggc tcc ggttcc tct tac gtt att ggt aag gca 384His Asp Phe Phe Ser Gly Ser Gly Ser Ser Tyr Val Ile Gly Lys Ala

115 120 125gaa aac acc gag gat gat gac tgg gac ttc taacttttaa aaagctgaag 434Glu Asn Thr Glu Asp Asp Asp Trp Asp Phe

130135 cgc 437<210>1074<211>138<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1074Ala Asp Val Ile Arg Leu Ile Ile Arg Asp Glu Ala Val His Gly Tyr 151015 Tyr Ile Gly Tyr Lys Tyr Gln Lys Ala Val Ala Lys Glu Thr Pro Glu

20 25 30Arg Gln Glu Glu Leu Lys Glu Tyr Thr Phe Asp Leu Leu Tyr Asp Leu

35 40 45Tyr Asp Asn Glu Thr Gln Tyr Ser Glu Asp Leu Tyr Asp Asp Leu Gly

50 55 60Trp Thr Glu Asp Val Lys Arg Phe Leu Arg Tyr Asn Ala Asn Lys Ala 65 70 75 80Leu Asn Asn Leu Gly Tyr Glu Gly Leu Phe Pro Ala Asp Glu Thr Lys

85 90 95Val Ser Pro Asn Ile Leu Ser Ala Leu Ser Pro Asn Ala Asp Glu Asn

100 105 110His Asp Phe Phe Ser Gly Ser Gly Ser Ser Tyr Val Ile Gly Lys Ala

115 120 125Glu Asn Thr Glu Asp Asp Asp Trp Asp Phe

130135<210>1075<211>567<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (544)<223>RXA01080<400>1075ttcagttctt cccttcaacg cccttgaagg gggaaactga taccagcaag cacactaggc 60ttgcgcacaa acggtattta gaagggaagt gagttcgagg atg cta atc gtg tat 115

Met Leu Ile Val Tyr

1 5ttt tcc tcg gcc acc gac aac acg cat cgt ttt gta caa aag ctc gat 163Phe Ser Ser Ala Thr Asp Asn Thr His Arg Phe Val Gln Lys Leu Asp

10 15 20tta ccc aac gtg cgc atc ccc ctc act agg gtg gaa gaa ccg ctg aaa 211Leu Pro Asn Val Arg Ile Pro Leu Thr Arg Val Glu Glu Pro Leu Lys

25 30 35atc aac gag ccc tac gtg cta atc acc ccg acc tat ggt ggt gga gtc 259Ile Asn Glu Pro Tyr Val Leu Ile Thr Pro Thr Tyr Gly Gly Gly Val

40 45 50tcc atg act gga gaa aac tcc cgc ccg gtc cca cca caa gtc atc agg 307Ser Met Thr Gly Glu Asn Ser Arg Pro Val Pro Pro Gln Val Ile Arg

55 60 65ttt tta aat gat gaa cac aac cgc agc ttc atc agg gca gtt gtt gca 355Phe Leu Asn Asp Glu His Asn Arg Ser Phe Ile Arg Ala Val Val Ala 70 75 80 85ggt gga aac tca aac ttc ggc tcc gat ttt ggg ttg gca ggc gag atc 403Gly Gly Asn Ser Asn Phe Gly Ser Asp Phe Gly Leu Ala Gly Glu Ile

90 95 100att tcc aag aaa tgt aaa gtg ccc tat gtc tac cgt ttc gag ctc atg 451Ile Ser Lys Lys Cys Lys Val Pro Tyr Val Tyr Arg Phe Glu Leu Met

105 110 115ggc aat gag gaa gat gta agt atc ctt cgt gga ggt ctt act caa aac 499Gly Asn Glu Glu Asp Val Ser Ile Leu Arg Gly Gly Leu Thr Gln Asn

120 125 130gcc caa gct ttg ggg ctg gaa cca caa gaa cca gtt acc tcg cga 544Ala Gln Ala Leu Gly Leu Glu Pro Gln Glu Pro Val Thr SerArg

135140145 taaaccttaa aacttaatca atc 567<210>1076<211>148<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1076Met Leu Ile Val Tyr Phe Ser Ser Ala Thr Asp Asn Thr His Arg Phe 151015 Val Gln Lys Leu Asp Leu Pro Asn Val Arg Ile Pro Leu Thr Arg Val

20 25 30Glu Glu Pro Leu Lys Ile Asn Glu Pro Tyr Val Leu Ile Thr Pro Thr

35 40 45Tyr Gly Gly Gly Val Ser Met Thr Gly Glu Asn Ser Arg Pro Val Pro

50 55 60Pro Gln Val Ile Arg Phe Leu Asn Asp Glu His Asn Arg Ser Phe Ile 65 70 75 80Arg Ala Val Val Ala Gly Gly Asn Ser Asn Phe Gly Ser Asp Phe Gly

85 90 95Leu Ala Gly Glu Ile Ile Ser Lys Lys Cys Lys Val Pro Tyr Val Tyr

100 105 110Arg Phe Glu Leu Met Gly Asn Glu Glu Asp Val Ser Ile Leu Arg Gly

115 120 125Gly Leu Thr Gln Asn Ala Gln Ala Leu Gly Leu Glu Pro Gln Glu Pro

130135140 Val Thr Ser Arg145<210>1077<211>650<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) } (627)<223>RXA00867<400>1077ttc ggc gac atg gac ttc aag gtt gcc ggc acc gca gac ttc atc acc 48Phe Gly Asp Met Asp Phe Lys Val Ala Gly Thr Ala Asp Phe Ile Thr 151015 gca ctt cag ctg gac acc aag ctg gac ggc att cct tcc aag gtg ctc 96Ala Leu Gln Leu Asp Thr Lys Leu Asp Gly Ile Pro Ser Lys Val Leu

20 25 30tcc gat gcg ctt gag cag gca cgc gat gcc cga ctg acc atc ctg aac 144Ser Asp Ala Leu Glu Gln Ala Arg Asp Ala Arg Leu Thr Ile Leu Asn

35 40 45acc atg gct gat gtc atc aac gga cct gat gag atg agc aag ttc gct 192Thr Met Ala Asp Val Ile Asn Gly Pro Asp Glu Met Ser Lys Phe Ala

50 55 60cct cgc atc acc acc gtg aag atc cca gtg gca aag atc ggt gag ctg 240Pro Arg Ile Thr Thr Val Lys Ile Pro Val Ala Lys Ile Gly Glu Leu 65 70 75 80atc gga cca aag ggt aag aac atc aac gct ctt acc gaa gag acc ggc 288Ile Gly Pro Lys Gly Lys Asn Ile Asn Ala Leu Thr Glu Glu Thr Gly

85 90 95gca aac atc tcc atc gaa gat gac ggc acc gtg ttc atc tct gca gct 336Ala Asn Ile Ser Ile Glu Asp Asp Gly Thr Val Phe Ile Ser Ala Ala

100 105 110gac ggc gca tct gct gaa gcg gcg atc gaa aag atc aac gct ctg gcg 384Asp Gly Ala Ser Ala Glu Ala Ala Ile Glu Lys Ile Asn Ala Leu Ala

115 120 125aac cca cag ctg cca aag gtt ggc gag cgc ttc ctc gga acc gtc gtc 432Asn Pro Gln Leu Pro Lys Val Gly Glu Arg Phe Leu Gly Thr Val Val

130 135 140aag acc acc gca ttc gga gca ttc gtt tcc ttg ctc cca ggc cgc gac 480Lys Thr Thr Ala Phe Gly Ala Phe Val Ser Leu Leu Pro Gly Arg Asp145 150 155 160ggc ctt gtt cac atc tcc aag ctg ggt aac ggc aag cga gta gaa aag 528Gly Leu Val His Ile Ser Lys Leu Gly Asn Gly Lys Arg Val Glu Lys

165 170 175gtc gac gat gtg gtg aag gtt ggc gag aag att cag gtc gaa atc gct 576Val Asp Asp Val Val Lys Val Gly Glu Lys Ile Gln Val Glu Ile Ala

180 185 190gac atc gac aac cgc ggc aag atc tcc ttg gtc cca gtt gtt gaa gag 624Asp Ile Asp Asn Arg Gly Lys Ile Ser Leu Val Pro Val Val Glu Glu

195200205 gac taattagttc tggctagatc ggg 650Asp<210>1078<211>209<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1078Phe Gly Asp Met Asp Phe Lys Val Ala Gly Thr Ala Asp Phe Ile Thr 151015 Ala Leu Gln Leu Asp Thr Lys Leu Asp Gly Ile Pro Ser Lys Val Leu

20 25 30Ser Asp Ala Leu Glu Gln Ala Arg Asp Ala Arg Leu Thr Ile Leu Asn

35 40 45Thr Met Ala Asp Val Ile Asn Gly Pro Asp Glu Met Ser Lys Phe Ala

50 55 60Pro Arg Ile Thr Thr Val Lys Ile Pro Val Ala Lys Ile Gly Glu Leu 65 70 75 80Ile Gly Pro Lys Gly Lys Asn Ile Asn Ala Leu Thr Glu Glu Thr Gly

85 90 95Ala Asn Ile Ser Ile Glu Asp Asp Gly Thr Val Phe Ile Ser Ala Ala

100 105 110Asp Gly Ala Ser Ala Glu Ala Ala Ile Glu Lys Ile Asn Ala Leu Ala

115 120 125Asn Pro Gln Leu Pro Lys Val Gly Glu Arg Phe Leu Gly Thr Val Val

130 135 140Lys Thr Thr Ala Phe Gly Ala Phe Val Ser Leu Leu Pro Gly Arg Asp145 150 155 160Gly Leu Val His Ile Ser Lys Leu Gly Asn Gly Lys Arg Val Glu Lys

165 170 175Val Asp Asp Val Val Lys Val Gly Glu LysIle Gln Val Glu Ile Ala

180 185 190Asp Ile Asp Asn Arg Gly Lys Ile Ser Leu Val Pro Val Val Glu Glu

195200205 Asp<210>1079<211>630<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1).<630><223>RXA01416<400>1079gct ggc gct tcc gaa aac gtt gtc aac cgc gtc aag gac ggt gca cca 48Ala Gly Ala Ser Glu Asn Val Val Asn Arg Val Lys Asp Gly Ala Pro 151015 gca cca acc gaa aag atc gtc tcc gac ggc ctt gaa gca gct aag cca 96Ala Pro Thr Glu Lys Ile Val Ser Asp Gly Leu Glu Ala Ala Lys Pro<400>1079 Ala Gly Ala Ser Glu Asn Val Val Asn Arg Val Lys Asp Gly Ala Pro 015 gca cca acc gaa aag atc gtc tcc gac ggc ctt gaa gca gct aag cca

20 25 30ttc atc gac atc ctg tgc cgc gca cag gaa ggt ctg gca cag cgc gtt 144Phe Ile Asp Ile Leu Cys Arg Ala Gln Glu Gly Leu Ala Gln Arg Val

35 40 45gga aac gca gcc aag gaa ttc cca ctg ttc cct cca tac acc gac gag 192Gly Asn Ala Ala Lys Glu Phe Pro Leu Phe Pro Pro Tyr Thr Asp Glu

50 55 60gtg tac tcc gca gtg gag cgc aag gta tcc aag aag cta gct tct ttg 240Val Tyr Ser Ala Val Glu Arg Lys Val Ser Lys Lys Leu Ala Ser Leu 65 70 75 80ctg acc ctg aag gca aag caa gag cgc gac gac gct acc aac gcc tac 288Leu Thr Leu Lys Ala Lys Gln Glu Arg Asp Asp Ala Thr Asn Ala Tyr

85 90 95atg gaa gaa atc gaa gcc gaa ctg ctt cca aag ttc gag gct tcc tac 336Met Glu Glu Ile Glu Ala Glu Leu Leu Pro Lys Phe Glu Ala Ser Tyr

100 105 110agc tca gca gct gaa gcg tcc aag gaa atc cgt gca gga tac aac gct 384Ser Ser Ala Ala Glu Ala Ser Lys Glu Ile Arg Ala Gly Tyr Asn Ala

115 120 125gtc atg aag gcc atc gtg cgc cgc atg atc ctc acc gat cac ttc cgc 432Val Met Lys Ala Ile Val Arg Arg Met Ile Leu Thr Asp His Phe Arg

130 135 140atc gac ggc cgc gga gtc acc gac atc cgt gac ctg gca gta gaa gtt 480Ile Asp Gly Arg Gly Val Thr Asp Ile Arg Asp Leu Ala Val Glu Val145 150 155 160gag ctc atc cca cgt gcg cac ggt tcc tcc ctc ttc gag cgt ggc gag 528Glu Leu Ile Pro Arg Ala His Gly Ser Ser Leu Phe Glu Arg Gly Glu

165 170 175acc cag atc ctt ggt gtc acc acc ctg gac atg ctc aag atg gaa cag 576Thr Gln Ile Leu Gly Val Thr Thr Leu Asp Met Leu Lys Met Glu Gln

180 185 190caa atc gac tcc ctg gca cca ggc gat gcg aag cgc tac atg cac cac 624Gln Ile Asp Ser Leu Ala Pro Gly Asp Ala Lys Arg Tyr Met His His

195 200 205tac aac 630Tyr Asn

210<210>1080<211>210<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1080Ala Gly Ala Ser Glu Asn Val Val Asn Arg Val Lys Asp Gly Ala Pro 151015 Ala Pro Thr Glu Lys Ile Val Ser Asp Gly Leu Glu Ala Ala Lys Pro

20 25 30Phe Ile Asp Ile Leu Cys Arg Ala Gln Glu Gly Leu Ala Gln Arg Val

35 40 45Gly Asn Ala Ala Lys Glu Phe Pro Leu Phe Pro Pro Tyr Thr Asp Glu

50 5560Val Tyr Ser Ala Val Glu Arg Lys Val Ser Lys Lys Leu Ala Ser Leu 65 70 75 80Leu Thr Leu Lys Ala Lys Gln Glu Arg Asp Asp Ala Thr Asn Ala Tyr

85 90 95Met Glu Glu Ile Glu Ala Glu Leu Leu Pro Lys Phe Glu Ala Ser Tyr

100 105 110Ser Ser Ala Ala Glu Ala Ser Lys Glu Ile Arg Ala Gly Tyr Asn Ala

115 120 125Val Met Lys Ala Ile Val Arg Arg Met Ile Leu Thr Asp His Phe Arg

130 135 140Ile Asp Gly Arg Gly Val Thr Asp Ile Arg Asp Leu Ala Val Glu Val145 150 155 160Glu Leu Ile Pro Arg Ala His Gly Ser Ser Leu Phe Glu Arg Gly Glu

165 170 175Thr Gln Ile Leu Gly Val Thr Thr Leu Asp Met Leu Lys Met Glu Gln

180 185 190Gln Ile Asp Ser Leu Ala Pro Gly Asp Ala Lys Arg Tyr Met His His

195 200 205Tyr Asn

210<210>1081<211>757<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (757)<223>RXA01486<400>1081agagaactgg taaggttttt accgttctag accgcagaaa tcttcgcggc gacaccgatg 60atcgccgagc agaactaaac atgaggagac ctactcgcat atg agc gat gta aag 115

Met Ser Asp Val Lys

1 5gac ttc gaa gac acc gaa ttt ggc ctg atc gag gcc gtc gca acc atc 163Asp Phe Glu Asp Thr Glu Phe Gly Leu Ile Glu Ala Val AlaThr Ile

10 15 20gac aac ggt gac ttc gga acc cgc acc atc cgt ttt gaa acc ggc caa 211Asp Asn Gly Asp Phe Gly Thr Arg Thr Ile Arg Phe Glu Thr Gly Gln

25 30 35ctt gcc cgc cag gca gat ggt gca gtg acc acc tac ctc gac gat gac 259Leu Ala Arg Gln Ala Asp Gly Ala Val Thr Thr Tyr Leu Asp Asp Asp

40 45 50acg atg ctg ctg gca acc acc acc gca tcc aac cag cca cgc gag ggc 307Thr Met Leu Leu Ala Thr Thr Thr Ala Ser Asn Gln Pro Arg Glu Gly

55 60 65ttt gac ttc ttc cca ctg acc gtg gac gtt gaa gag cgt atg tac gca 355Phe Asp Phe Phe Pro Leu Thr Val Asp Val Glu Glu Arg Met Tyr Ala 70 75 80 85gct ggt cgc atc cct ggc tct ttc ttc cgt cgg gag ggt cgc cca tcc 403Ala Gly Arg Ile Pro Gly Ser Phe Phe Arg Arg Glu Gly Arg Pro Ser

90 95 100acc gaa gct atc ctg gct tgc cgt ctc atc gac cgc cca ctg cgc cca 451Thr Glu Ala Ile Leu Ala Cys Arg Leu Ile Asp Arg Pro Leu Arg Pro

105 110 115acc ttt gtt aag ggc ctg cgc aat gag gtt cag atc gtt gtc acc gtc 499Thr Phe Val Lys Gly Leu Arg Asn Glu Val Gln Ile Val Val Thr Val

120 125 130atg tcc atg aac cct gag gat tac tac gat gtc gta gca atc aac gga 547Met Ser Met Asn Pro Glu Asp Tyr Tyr Asp Val Val Ala Ile Asn Gly

135 140 145gct tcc gca gca acc cgc atc tcc gga ctt cct gtc tcc ggc gct gtc 595Ala Ser Ala Ala Thr Arg Ile Ser Gly Leu Pro Val Ser Gly Ala Val150 155 160 165ggtggc gtt cgc atg gca ctg gtt ggt gat gaa aag cac cca gaa ggc 643Gly Gly Val Arg Met Ala Leu Val Gly Asp Glu Lys His Pro Glu Gly

170 175 180caa tgg gtt gca ttc cca acc cac gct caa cat gag cag tcc gta ttt 691Gln Trp Val Ala Phe Pro Thr His Ala Gln His Glu Gln Ser Val Phe

185 190 195gaa atc gtt gtg gct ggt cgc ctc gtc gag cgc aag cgc ggc aac aag 739Glu Ile Val Val Ala Gly Arg Leu Val Glu Arg Lys Arg Gly Asn Lys

200 205 210acc ttc tcc gac gtc gca 757Thr Phe Ser Asp Val Ala

215<210>1082<211>219<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1082Met Ser Asp Val Lys Asp Phe Glu Asp Thr Glu Phe Gly Leu Ile Glu 151015 Ala Val Ala Thr Ile Asp Asn Gly Asp Phe Gly Thr Arg Thr Ile Arg

20 25 30Phe Glu Thr Gly Gln Leu Ala Arg Gln Ala Asp Gly Ala Val Thr Thr

35 40 45Tyr Leu Asp Asp Asp Thr Met Leu Leu Ala Thr Thr Thr Ala Ser Asn

50 55 60Gln Pro Arg Glu Gly Phe Asp Phe Phe Pro Leu Thr Val Asp Val Glu 65 70 75 80Glu Arg Met Tyr Ala Ala Gly Arg Ile Pro Gly Ser Phe Phe Arg Arg

85 90 95Glu Gly Arg Pro Ser Thr Glu Ala Ile Leu Ala Cys Arg Leu Ile Asp

100 105 110Arg Pro Leu Arg Pro Thr Phe Val Lys Gly Leu Arg Asn Glu Val Gln

115 120 125Ile Val Val Thr Val Met Ser Met Asn Pro Glu Asp Tyr Tyr Asp Val

130 135 140Val Ala Ile Asn Gly Ala Ser Ala Ala Thr Arg Ile Ser Gly Leu Pro145 150 155 160Val Ser Gly Ala Val Gly Gly Val Arg Met Ala Leu Val Gly Asp Glu

165 170 175Lys His Pro Glu Gly Gln Trp Val Ala Phe Pro Thr His Ala Gln His

180 185 190Glu Gln Ser Val Phe Glu Ile Val Val Ala Gly Arg Leu Val Glu Arg

195 200 205Lys Arg Gly Asn Lys Thr Phe Ser Asp Val Ala

210215<210>1083<211>651<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (628)<223>RXA01678<400>1083tattgtccag gcgcaggaaa atatctcata gttcaacatc gcaaatatca ccgacttcca 60cggctatatc tctgcaactg cagctcaccc cggtgcagca atg ctg aaa tgt gca 115

Met Leu Lys Cys Ala

1 5gtc gat gaa gcc gct ggc gga cgc gcc caa gct ttc gta tcc tca ggc 163Val Asp Glu Ala Ala Gly Gly Arg Ala Gln Ala Phe Val Ser Ser Gly

10 15 20gat aac att ggt ggc agc ccg ttc caa tcc tcc att ctt ggt gat gaa 211Asp Asn Ile Gly Gly Ser Pro Phe Gln Ser Ser Ile Leu Gly Asp Glu

25 30 35ccc acc ttg gaa gca ctc aac caa atg ggt ctt gat tac tca gca gtg 259Pro Thr Leu Glu Ala Leu Asn Gln Met Gly Leu Asp Tyr Ser Ala Val

40 45 50ggc aac cac gaa ttt gat aaa ggc tac gca gac tta agc agt cga gtc 307Gly Asn His Glu Phe Asp Lys Gly Tyr Ala Asp Leu Ser Ser Arg Val

55 60 65gct gac ctt gct gat ttt gat tat ctc ggc gca aac gtt gag ggc gaa 355Ala Asp Leu Ala Asp Phe Asp Tyr Leu Gly Ala Asn Val Glu Gly Glu 70 75 80 85aac cca gat ctt gca cca tat gga att tct cac ctt gat ggt gtg aag 403Asn Pro Asp Leu Ala Pro Tyr Gly Ile Ser His Leu Asp Gly Val Lys

90 95 100gtt gct ttc gta ggc acc gta tcc caa gaa act ccg atg ttg gtc aat 451Val Ala Phe Val Gly Thr Val Ser Gln Glu Thr Pro Met Leu Val Asn

105 110 115tct gaa ggc att gag gga atc acg ttt act gac cca ctt gaa gca acc 499Ser Glu Gly Ile Glu Gly Ile Thr Phe Thr Asp Pro Leu Glu Ala Thr

120 125 130aac cgt gta gct gat gaa ctc gtg gga agt ggc gca gca gat gtt gtc 547Asn Arg Val Ala Asp Glu Leu Val Gly Ser Gly Ala Ala Asp Val Val

135 140 145gtt gcg ctt tac cac gaa ggc att acc ggc acc gaa gca tgg tca gaa 595Val Ala Leu Tyr His Glu Gly Ile Thr Gly Thr Glu Ala Trp Ser Glu150 155 160 165aat atc gac gtt gtt ttc gca ggt cac acc cac taagttcgtg atctaggaac 648Asn Ile Asp Val Val Phe Ala Gly His Thr His

170175 cga 651<210>1084<211>176<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1084Met Leu Lys Cys Ala Val Asp Glu Ala Ala Gly Gly Arg Ala Gln Ala 151015 Phe Val Ser Set Gly Asp Asn Ile Gly Gly Ser Pro Phe Gln Ser Ser

20 25 30Ile Leu Gly Asp Glu Pro Thr Leu Glu Ala Leu Asn Gln Met Gly Leu

35 40 45Asp Tyr Ser Ala Val Gly Asn His Glu Phe Asp Lys Gly Tyr Ala Asp

50 55 60Leu Ser Ser Arg Val Ala Asp Leu Ala Asp Phe Asp Tyr Leu Gly Ala 65 70 75 80Asn Val Glu Gly Glu Asn Pro Asp Leu Ala Pro Tyr Gly Ile Ser His

85 90 95Leu Asp Gly Val Lys Val Ala Phe Val Gly Thr Val Ser Gln Glu Thr

100 105 110Pro Met Leu Val Asn Ser Glu Gly Ile Glu Gly Ile Thr Phe Thr Asp

115 120 125Pro Leu Glu Ala Thr Asn Arg Val Ala Asp Glu Leu Val Gly Ser Gly

130 135 140Ala Ala Asp Val Val Val Ala Leu Tyr His Glu Gly Ile Thr Gly Thr145 150 155 160Glu Ala Trp Ser Glu Asn Ile Asp Val Val Phe Ala Gly His Thr His

165170175<210>1085<211>1359<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1336)<223>RXA01679<400>1085cattaccggc accgaagcat ggtcagaaaa tatcgacgtt gttttcgcag gtcacaccca 60ctaagttcgt gatctaggaa ccgacaacgg tccactaatc atg cag tct gga aac 115

Met Gln Ser Gly Asn

1 5tac ggg cac gca ctt gcc gat gta gat ttc agc ttc aac cac gac acc 163Tyr Gly His Ala Leu Ala Asp Val Asp Phe Ser Phe Asn His Asp Thr

10 15 20ggt gag ctc acc gta gat gat gcc cgc atgctc gga gtc gac gat atc 211Gly Glu Leu Thr Val Asp Asp Ala Arg Met Leu Gly Val Asp Asp Ile

25 30 35aac gcg tgt gaa aac cca gat gac acc att gca gat att gtt gct cag 259Asn Ala Cys Glu Asn Pro Asp Asp Thr Ile Ala Asp Ile Val Ala Gln

40 45 50gcg gaa ctt gat gct ggt gaa gcc ggc aaa gaa gta gta gcg acc atc 307Ala Glu Leu Asp Ala Gly Glu Ala Gly Lys Glu Val Val Ala Thr Ile

55 60 65gat ggc gat ttt ctc cgc gcc agc gac gaa gga gca gaa tct ggc tcc 355Asp Gly Asp Phe Leu Arg Ala Ser Asp Glu Gly Ala Glu Ser Gly Ser 70 75 80 85aac tac ggc gct gaa tcc cag ctc gtc aac atg att gcc agt gct gtg 403Asn Tyr Gly Ala Glu Ser Gln Leu Val Asn Met Ile Ala Ser Ala Val

90 95 100cgt tgg tcc atg tcc acc aat acc gcc acc acc gca gac att ggg ctt 451Arg Trp Ser Met Ser Thr Asn Thr Ala Thr Thr Ala Asp Ile Gly Leu

105 110 115atg aac gcc gga gga ctc cac act gac cta ttc agc ggc gat gtt acc 499Met Asn Ala Gly Gly Leu His Thr Asp Leu Phe Ser Gly Asp Val Thr

120 125 130tac gcc gaa gct ttt gaa atc cag cct ttc tcc ggt gaa gat tca ttt 547Tyr Ala Glu Ala Phe Glu Ile Gln Pro Phe Ser Gly Glu Asp Ser Phe

135 140 145gtc acc ctc aag gga tca gtc ttc aaa gat gcc ctt gac cag cag tgg 595Val Thr Leu Lys Gly Ser Val Phe Lys Asp Ala Leu Asp Gln Gln Trp150 155 160 165gaa gaa ggt tct gca cga cca gtg gca gca ctt ggc gta tcc gac aac 643Glu Glu Gly Ser Ala Arg Pro Val Ala Ala Leu Gly Val Ser Asp Asn

170 175 180gtt tcc tac acc tac gac atc aac cgt cca atc ggt gac cgc gtc act 691Val Ser Tyr Thr Tyr Asp Ile Asn Arg Pro Ile Gly Asp Arg Val Thr

185 190 195tcc gtg acc att gat gat acc cca ctt gat ccg gaa cgc gac tac gtt 739Ser Val Thr Ile Asp Asp Thr Pro Leu Asp Pro Glu Arg Asp Tyr Val

200 205 210gtt gca gct tcc ctg tac ctc cag tcc ggc aac gaa ggt atg acc gca 787Val Ala Ala Ser Leu Tyr Leu Gln Ser Gly Asn Glu Gly Met Thr Ala

215 220 225ctg acc cgc gga acc gca cct gca caa acc ggc atc gtg gat gta cag 835Leu Thr Arg Gly Thr Ala Pro Ala Gln Thr Gly Ile Val Asp Val Gln230 235 240 245tcc acc atc gga tac ttg tcc aac aac aat gtc acc cca cgt act ggt 883Ser Thr Ile Gly Tyr Leu Ser Asn Asn Asn Val Thr Pro Arg Thr Gly

250 255 260caa gcc cag att tcc atc acc cca tcc ggt gag ttc aat gcg ggt gaa 931Gln Ala Gln Ile Ser Ile Thr Pro Ser Gly Glu Phe Asn Ala Gly Glu

265 270 275acc atc acc ctt gac atg gca gga ctc cgc tac acc caa ggc gac act 979Thr Ile Thr Leu Asp Met Ala Gly Leu Arg Tyr Thr Gln Gly Asp Thr

280 285 290gcc acg gaa gta act gtc agc ctt cga gaa gaa att gtt tca gca cca 1027Ala Thr Glu Val Thr Val Ser Leu Arg Glu Glu Ile Val Ser Ala Pro

295 300 305att gat cct cag ctc gga gaa gct ggc ttt ggc gaa gct gga acc gcg 1075Ile Asp Pro Gln Leu Gly Glu Ala Gly Phe Gly Glu Ala Gly Thr Ala310 315 320 325aca gtg agc ttg gac att cct gca acc ctt tca ggt act caa aac ctc 1123Thr Val Ser Leu Asp Ile Pro Ala Thr Leu Ser Gly Thr Gln Asn Leu

330 335 340gtt gtc acc acc gat acc ggc acc cgt att tcc atg cca gtt gag att 1171Val Val Thr Thr Asp Thr Gly Thr Arg Ile Ser Met Pro Val Glu Ile

345 350 355gtt ggc gca gaa caa cca gca ccg caa cca gca ggt tcc tct gtt tta 1219Val Gly Ala Glu Gln Pro Ala Pro Gln Pro Ala Gly Ser Ser Val Leu

360 365 370gga act gga gtg ctc agt gga ctc ctc ggc att gtt gta gga att cta 1267Gly Thr Gly Val Leu Ser Gly Leu Leu Gly Ile Val Val Gly Ile Leu

375 380 385gga atg gtc ggt ctg gtg aac tgg att gac cca agc ttc att caa cag 1315Gly Met Val Gly Leu Val Asn Trp Ile Asp Pro Ser Phe Ile Gln Gln390 395 400 405atc cag cag caa atc ttt gct taaatttagt aaaaagcatg cat 1359Ile Gln Gln Gln Ile Phe Ala

410<210>1086<211>412<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1086Met Gln Ser Gly Asn Tyr Gly His Ala Leu Ala Asp Val Asp Phe Ser 151015 Phe Asn His Asp Thr Gly Glu Leu Thr Val Asp Asp Ala Arg Met Leu

20 25 30Gly Val Asp Asp Ile Asn Ala Cys Glu Asn Pro Asp Asp Thr Ile Ala

35 40 45Asp Ile Val Ala Gln Ala Glu Leu Asp Ala Gly Glu Ala Gly Lys Glu

50 55 60Val Val Ala Thr Ile Asp Gly Asp Phe Leu Arg Ala Ser Asp Glu Gly 65 70 75 80 Ala Glu Ser Gly Ser Asn Tyr Gly Ala Glu Ser Gln Leu Val AsnMet

85 90 95Ile Ala Ser Ala Val Arg Trp Ser Met Ser Thr Asn Thr Ala Thr Thr

100 105 110Ala Asp Ile Gly Leu Met Asn Ala Gly Gly Leu His Thr Asp Leu Phe

115 120 125Ser Gly Asp Val Thr Tyr Ala Glu Ala Phe Glu Ile Gln Pro Phe Ser

130 135 140Gly Glu Asp Ser Phe Val Thr Leu Lys Gly Ser Val Phe Lys Asp Ala145 150 155 160Leu Asp Gln Gln Trp Glu Glu Gly Ser Ala Arg Pro Val Ala Ala Leu

165 170 175Gly Val Ser Asp Asn Val Ser Tyr Thr Tyr Asp Ile Asn Arg Pro Ile

180 185 190Gly Asp Arg Val Thr Ser Val Thr Ile Asp Asp Thr Pro Leu Asp Pro

195 200 205Glu Arg Asp Tyr Val Val Ala Ala Ser Leu Tyr Leu Gln Ser Gly Asn

210 215 220Glu Gly Met Thr Ala Leu Thr Arg Gly Thr Ala Pro Ala Gln Thr Gly225 230 235 240Ile Val Asp Val Gln Ser Thr Ile Gly Tyr Leu Ser Asn Asn Asn Val

245 250 255Thr Pro Arg Thr Gly Gln Ala Gln Ile Ser Ile Thr Pro Ser Gly Glu

260 265 270Phe Asn Ala Gly Glu Thr Ile Thr Leu Asp Met Ala Gly Leu Arg Tyr

275 280 285Thr Gln Gly Asp Thr Ala Thr Glu Val Thr Val Ser Leu Arg Glu Glu

290 295 300Ile Val Ser Ala Pro Ile Asp Pro Gln Leu Gly Glu Ala Gly Phe Gly305 310 315 320Glu Ala Gly Thr Ala Thr Val Ser Leu Asp Ile Pro Ala Thr Leu Ser

325 330 335Gly Thr Gln Asn Leu Val Val Thr Thr Asp Thr Gly Thr Arg Ile Ser

340 345 350Met Pro Val Glu Ile Val Gly Ala Glu Gln Pro Ala Pro Gln Pro Ala

355 360 365Gly Ser Ser Val Leu Gly Thr Gly Val Leu Ser Gly Leu Leu Gly Ile

370 375 380Val Val Gly Ile Leu Gly Met Val Gly Leu Val Asn Trp Ile Asp Pro385 390 395 400Ser Phe Ile Gln Gln Ile Gln Gln Gln Ile Phe Ala

405410<210>1087<211>1071<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1048)<223>RXN01488<400>1087ccagcgctta aggccggtca ccggccatca agcttgtcac atcgggtgcc ttatgatggt 60gcccgacctt aaaaataaaa acctgaaagg ttaaaaacgc atg agc aaa aaa gcc 115

Met Ser Lys Lys Ala

1 5atc ctt gat atc gac acc ggc atc gat gat gcc ctc gca ctt gcc tac 163Ile Leu Asp Ile Asp Thr Gly Ile Asp Asp Ala Leu Ala Leu Ala Tyr

10 15 20gca ctg ggc tca cct gaa cta gag ctc att ggt gtc acc acc acc tac 211Ala Leu Gly Ser Pro Glu Leu Glu Leu Ile Gly Val Thr Thr Thr Tyr

25 30 35ggt aac gtg cta ctc gaa acc ggt gca gtc aat gac ctg gca ctg ctt 259Gly Asn Val Leu Leu Glu Thr Gly Ala Val Asn Asp Leu Ala Leu Leu

40 45 50gat ctg ttc ggt gca cca gaa gta cct gtg tac ttg ggt gag cca cac 307Asp Leu Phe Gly Ala Pro Glu Val Pro Val Tyr Leu Gly Glu Pro His

55 60 65gca cag acc aag gat ggc ttt gaa gtt ctt gag atc tcc gcg ttc att 355Ala Gln Thr Lys Asp Gly Phe Glu Val Leu Glu Ile Ser Ala Phe Ile 70 75 80 85cac gga caa aac ggc atc ggc gaa gtc gag ctg cca gca agc gag tca 403His Gly Gln Asn Gly Ile Gly Glu Val Glu Leu Pro Ala Ser Glu Ser

90 95 100aag gca ctc ccc ggc gca gtg gat ttc ctc att gat tcc gtc aac acc 451Lys Ala Leu Pro Gly Ala Val Asp Phe Leu Ile Asp Ser Val Asn Thr

105 110 115cac ggc gat gac ctg gtg atc atc gca act ggt ccc atg acc aac ctg 499His Gly Asp Asp Leu Val Ile Ile Ala Thr Gly Pro Met Thr Asn Leu

120 125 130tct gcg gca atc gca aag gat cca agc ttt gct tcc aag gct cac gtg 547Ser Ala Ala Ile Ala Lys Asp Pro Ser Phe Ala Ser Lys Ala His Val

135 140 145gtc atc atg ggt ggc gcc ttg act gtc cca ggc aac gtc agc aca tgg 595Val Ile Met Gly Gly Ala Leu Thr Val Pro Gly Asn Val Ser Thr Trp150 155 160 165gca gaa gca aac atc aac cag gac cca gat gca gca aac gat ctg ttc 643Ala Glu Ala Asn Ile Asn Gln Asp Pro Asp Ala Ala Asn Asp Leu Phe

170 175 180cgt tcc ggt gca gat gtc acc atg atc ggt ctt gat gtc acc ctg cag 691Arg Ser Gly Ala Asp Val Thr Met Ile Gly Leu Asp Val Thr Leu Gln

185 190 195acc ctt ctt acc aag aag cac act gcg cag tgg cgc gaa ctg ggc act 739Thr Leu Leu Thr Lys Lys His Thr Ala Gln Trp Arg Glu Leu Gly Thr

200 205 210cca gct gct atc gca ctg gcc gac atg act gat tac tac atc aag gca 787Pro Ala Ala Ile Ala Leu Ala Asp Met Thr Asp Tyr Tyr Ile Lys Ala

215 220 225tat gag acc acc gca cca cac ctg ggc ggt tgc ggc ctg cac gac cca 835Tyr Glu Thr Thr Ala Pro His Leu Gly Gly Cys Gly Leu His Asp Pro230 235 240 245ctg gca gta ggc gtt gca gtg gac cca agc ctg gtc act ttg ctc ccc 883Leu Ala Val Gly Val Ala Val Asp Pro Ser Leu Val Thr Leu Leu Pro

250 255 260atc aac ctc aag gta gac att gag ggc gag acc cgt gga cgc acc att 931Ile Asn Leu Lys Val Asp Ile Glu Gly Glu Thr Arg Gly Arg Thr Ile

265 270 275ggc gat gaa gtc cgc ctc aac gat cca gtg cgc acc tcc cgc gca gct 979Gly Asp Glu Val Arg Leu Asn Asp Pro Val Arg Thr Ser Arg Ala Ala

280 285 290gtc gcc gta gac gtg gat cgt ttc ctt tct gaa ttc atg acc cgc atc 1027Val Ala Val Asp Val Asp Arg Phe Leu Ser Glu Phe Met Thr Arg Ile

295300305 ggc cga gtc gca gca cag cag taaaagcagc tctggtgaag gtt 1071Gly Arg Val Ala Ala Gln Gln 310315<210>1088<211>316<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1088Met Ser Lys Lys Ala Ile Leu Asp Ile Asp Thr Gly Ile Asp Asp Ala 151015 Leu Ala Leu Ala Tyr Ala Leu Gly Ser Pro Glu Leu Glu Leu Ile Gly

20 25 30Val Thr Thr Thr Tyr Gly Asn Val Leu Leu Glu Thr Gly Ala Val Asn

3540 45Asp Leu Ala Leu Leu Asp Leu Phe Gly Ala Pro Glu Val Pro Val Tyr

50 55 60Leu Gly Glu Pro His Ala Gln Thr Lys Asp Gly Phe Glu Val Leu Glu 65 70 75 80Ile Ser Ala Phe Ile His Gly Gln Asn Gly Ile Gly Glu Val Glu Leu

85 90 95Pro Ala Ser Glu Ser Lys Ala Leu Pro Gly Ala Val Asp Phe Leu Ile

100 105 110Asp Ser Val Asn Thr His Gly Asp Asp Leu Val Ile Ile Ala Thr Gly

115 120 125Pro Met Thr Asn Leu Ser Ala Ala Ile Ala Lys Asp Pro Ser Phe Ala

130 135 140Ser Lys Ala His Val Val Ile Met Gly Gly Ala Leu Thr Val Pro Gly145 150 155 160Asn Val Ser Thr Trp Ala Glu Ala Asn Ile Asn Gln Asp Pro Asp Ala

165 170 175Ala Asn Asp Leu Phe Arg Ser Gly Ala Asp Val Thr Met Ile Gly Leu

180 185 190Asp Val Thr Leu Gln Thr Leu Leu Thr Lys Lys His Thr Ala Gln Trp

195 200 205Arg Glu Leu Gly Thr Pro Ala Ala Ile Ala Leu Ala Asp Met Thr Asp

210 215 220Tyr Tyr Ile Lys Ala Tyr Glu Thr Thr Ala Pro His Leu Gly Gly Cys225 230 235 240Gly Leu His Asp Pro Leu Ala Val Gly Val Ala Val Asp Pro Ser Leu

245 250 255Val Thr Leu Leu Pro Ile Asn Leu Lys Val Asp Ile Glu Gly Glu Thr

260265 270Arg Gly Arg Thr Ile Gly Asp Glu Val Arg Leu Asn Asp Pro Val Arg

275 280 285Thr Ser Arg Ala Ala Val Ala Val Asp Val Asp Arg Phe Leu Ser Glu

290295300 Phe Met Thr Arg Ile Gly Arg Val Ala Ala Gln Gln 305310315<210>1089<211>366<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).)

Val Ala Arg Val Val

1 5gtc aat gtc atg cct aag gct gag att ctg gat ccc cag ggg cag gcg 163Val Asn Val Met Pro Lys Ala Glu Ile Leu Asp Pro Gln Gly Gln Ala

10 15 20gta cac cgc gcc ctc gga cgt atc gga gtt tct ggc gtt tcc gat gtc 211Val His Arg Ala Leu Gly Arg Ile Gly Val Ser Gly Val Ser Asp Val

25 30 35cgt cag gga aag cgc ttc gag ctt gag gta gat gat tcc gtc acc gaa 259Arg Gln Gly Lys Arg Phe Glu Leu Glu Val Asp Asp Ser Val Thr Glu

40 45 50gct gac cta aag aaa att gct gaa acc ctc ctc gca aac acc gtc atc 307Ala Asp Leu Lys Lys Ile Ala Glu Thr Leu Leu Ala Asn Thr Val Ile

556065 gaa gac ttc gat gtg gtg gga gtt gag gtc gcg aag tgagcgccaa 353Glu Asp Phe Asp Val Val Gly Val Glu Val Ala Lys 707580 aatcggtgtc att 366<210>1090<211>81<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1090Val Ala Arg Val Val Val Asn Val Met Pro Lys Ala Glu Ile Leu Asp 151015 Pro Gln Gly Gln Ala Val His Arg Ala Leu Gly Arg Ile Gly Val Ser

20 2530Gly Val Ser Asp Val Arg Gln Gly Lys Arg Phe Glu Leu Glu Val Asp

35 40 45Asp Ser Val Thr Glu Ala Asp Leu Lys Lys Ile Ala Glu Thr Leu Leu

505560 Ala Asn Thr Val Ile Glu Asp Phe Asp Val Val Gly Val Glu Val Ala 65707580 Lys<210>1091<211>498<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (475)<223>RXC00560<400>1091aaggacgact tctggggagc ggtgtggatt ctcacgggga ttctcatgcg gattatcaga 60catatggaca ctttaacggt tcgtactagg ctgatgcttc atg agg att gat ccg 115

Met Arg Ile Asp Pro

1 5ctg gaa acc cgg caa gcc gta ttg gcc gtc aaa gac tgg att gaa ggg 163Leu Glu Thr Arg Gln Ala Val Leu Ala Val Lys Asp Trp Ile Glu Gly

10 15 20gag gga gac gtc aaa aag cct ggt cgt gcg gca ctt gcc gcc gca act 211Glu Gly Asp Val Lys Lys Pro Gly Arg Ala Ala Leu Ala Ala Ala Thr

25 30 35cgc ctg agc gtc cga ctg ctc gcg caa cac gcg ccg gga aac agc gtg 259Arg Leu Ser Val Arg Leu Leu Ala Gln His Ala Pro Gly Asn Ser Val

40 45 50gag gtg cgg gta ccc cca ttt gtt gcg gtg caa tgc ata gag ggg cca 307Glu Val Arg Val Pro Pro Phe Val Ala Val Gln Cys Ile Glu Gly Pro

55 60 65aaa cat aca cgc ggc aca cca ccc aac gtg gtg gag acc gac gcc aag 355Lys His Thr Arg Gly Thr Pro Pro Asn Val Val Glu Thr Asp Ala Lys70 75 80 85acc tgg tta cgc tta gca cct ggg caa acc acattt gat gca gaa ttt 403Thr Trp Leu Arg Leu Ala Pro Gly Gln Thr Thr Phe Asp Ala Glu Phe

90 95 100gaa agc gga aaa att agc gca tca ggt acc cga gcc aaa gag att gcg 451Glu Ser Gly Lys Ile Ser Ala Ser Gly Thr Arg Ala Lys Glu Ile Ala

105 110 115gac tgg tta cca gtg gtc aaa ctt tagatttcct aatgctcatt agt 498Asp Trp Leu Pro Val Val Lys Leu

120125<210>1092<211>125<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1092Met Arg Ile Asp Pro Leu Glu Thr Arg Gln Ala Val Leu Ala Val Lys 151015 Asp Trp Ile Glu Gly Glu Gly Asp Val Lys Lys Pro Gly Arg Ala Ala

20 25 30Leu Ala Ala Ala Thr Arg Leu Ser Val Arg Leu Leu Ala Gln His Ala

35 40 45Pro Gly Asn Ser Val Glu Val Arg Val Pro Pro Phe Val Ala Val Gln

50 55 60Cys Ile Glu Gly Pro Lys His Thr Arg Gly Thr Pro Pro Asn Val Val 65 70 75 80Glu Thr Asp Ala Lys Thr Trp Leu Arg Leu Ala Pro Gly Gln Thr Thr

85 90 95Phe Asp Ala Glu Phe Glu Ser Gly Lys Ile Ser Ala Ser Gly Thr Arg

100 105 110Ala Lys Glu Ile Ala Asp Trp Leu Pro Val Val Lys Leu

115120125<210>1093<211>1305<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1282)<223>RXC01088<400>1093tgccttgagt ctaattctcc cgcccgtgcg atgggtttaa gctggactga taaacctttt 60gtgaaccgaa ttttttaact gatttgaaga agcgagaata atg gga ctg tgg atc 115

Met Gly Leu Trp Ile

1 5gat gca acc gct ggc gtt gca ggg gat atg ttg ctg gga gca ctc att 163Asp Ala Thr Ala Gly Val Ala Gly Asp Met Leu Leu Gly Ala Leu Ile

10 15 20gat gca ggt gca gaa cta gaa aaa atc caa cag gtt gtg gaa gca gtc 211Asp Ala Gly Ala Glu Leu Glu Lys Ile Gln Gln Val Val Glu Ala Val

25 30 35atc ccc ggt gac gtg ctc ttg cgc acc gaa gag gta gtg cgc caa ggc 259Ile Pro Gly Asp Val Leu Leu Arg Thr Glu Glu Val Val Arg Gln Gly

40 45 50caa cga ggc atc aag ctg cat gtg gac gca caa cat gaa cac cat cat 307Gln Arg Gly Ile Lys Leu His Val Asp Ala Gln His Glu His His His

55 60 65cac cgc cac tta agc acc att aaa gaa ctg ctt gtc aat gct gac atc 355His Arg His Leu Ser Thr Ile Lys Glu Leu Leu Val Asn Ala Asp Ile 70 75 80 85cct gaa caa acc aag cag gat gcc tta ggc gtt ttt gaa ctc atc gct 403Pro Glu Gln Thr Lys Gln Asp Ala Leu Gly Val Phe Glu Leu Ile Ala

90 95 100atc gct gaa gga aaa gtc cac ggc atc gag ccg gag aaa atc cac ttc 451Ile Ala Glu Gly Lys Val His Gly Ile Glu Pro Glu Lys Ile His Phe

105 110 115cat gag gta gga gct tgg gat tcc atc gca gac att gtg ggt gtg tgc 499His Glu Val Gly Ala Trp Asp Ser Ile Ala Asp Ile Val Gly Val Cys

120 125 130gaa gcg atc agg cag ctt aac cca ggt ttg att gct gca tctccg att 547Glu Ala Ile Arg Gln Leu Asn Pro Gly Leu Ile Ala Ala Ser Pro Ile

135 140 145gct tta gga ttc gga cgc atc aag gca gct cac gga gat att cca gtg 595Ala Leu Gly Phe Gly Arg Ile Lys Ala Ala His Gly Asp Ile Pro Val150 155 160 165cca gtt cca gcc gtg gca gag ctg gtg aaa ggc tgg ccc acc caa acc 643Pro Val Pro Ala Val Ala Glu Leu Val Lys Gly Trp Pro Thr Gln Thr

170 175 180gga gct ctt atg gag agc acc gaa cct gtt ggt gaa tta gcc acc cca 691Gly Ala Leu Met Glu Ser Thr Glu Pro Val Gly Glu Leu Ala Thr Pro

185 190 195act ggt gtt gcg ttg atc cgt cac ttt gcc acc caa gat ggc cct ttc 739Thr Gly Val Ala Leu Ile Arg His Phe Ala Thr Gln Asp Gly Pro Phe

200 205 210cca ggt ggc atc atc aat gaa gtt ggc att ggt gca gga aca aaa gat 787Pro Gly Gly Ile Ile Asn Glu Val Gly Ile Gly Ala Gly Thr Lys Asp

215 220 225aca gaa ggc cgt cca aat ata gtg cgc gca att ttg ttc aac acc tct 835Thr Glu Gly Arg Pro Asn Ile Val Arg Ala Ile Leu Phe Asn Thr Ser230 235 240 245agg agt aac cca gat acc cgc aca ctg gtg caa tta gaa gcc aat gtt 883Arg Set Asn Pro Asp Thr Arg Thr Leu Val Gln Leu Glu Ala Asn Val

250 255 260gat gat caa gac cca cgg ctg tgg cca gga gta ata gag atc ctc ttt 931Asp Asp Gln Asp Pro Arg Leu Trp Pro Gly Val Ile Glu Ile Leu Phe

265 270 275gcc gct ggc gca gta gat gca tgg ctg act cca att ttg atg aag aag 979Ala Ala Gly Ala Val Asp Ala Trp Leu Thr Pro Ile Leu Met Lys Lys

280 285 290ggc cgt cct gca cat agg gtg tca gca ttg gtg gat agc tcc gag gtg 1027Gly Arg Pro Ala His Arg Val Ser Ala Leu Val Asp Ser Ser Glu Val

295 300 305gaa gca gtg aaa acc gca tta ttt gca gcc acc acg act ttt ggg atc 1075Glu Ala Val Lys Thr Ala Leu Phe Ala Ala Thr Thr Thr Phe Gly Ile310 315 320 325aga tca tgg gaa gtc gaa cga gaa ggc ttg gac cgt cgt ttc gaa caa 1123Arg Ser Trp Glu Val Glu Arg Glu Gly Leu Asp Arg Arg Phe Glu Gln

330 335 340gtc gag gtg gac gga cac acc atc aac atc aaa atc ggt tcc cgt gat 1171Val Glu Val Asp Gly His Thr Ile Asn Ile Lys Ile Gly Ser Arg Asp

345 350 355gat caa gta atc agt gca cag tcc gag ttt gaa gat att cgg tct gca 1219Asp Gln Val Ile Ser Ala Gln Ser Glu Phe Glu Asp Ile Arg Ser Ala

360 365 370gcg gtg gcc ttg gga att tca gag cgg gaa gtt gtg gca aga att ccg 1267Ala Val Ala Leu Gly Ile Ser Glu Arg Glu Val Val Ala Arg Ile Pro

375380385 caa ggc acc acc gag taacaaccaa aaggtcgact gct 1305Gln Gly Thr Thr Glu390<210>1094<211>394<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1094Met Gly Leu Trp Ile Asp Ala Thr Ala Gly Val Ala Gly Asp Met Leu 151015 Leu Gly Ala Leu Ile Asp Ala Gly Ala Glu Leu Glu Lys Ile Gln Gln

20 25 30Val Val Glu Ala Val Ile Pro Gly Asp Val Leu Leu Arg Thr Glu Glu

35 40 45Val Val Arg Gln Gly Gln Arg Gly Ile Lys Leu His Val Asp Ala Gln

50 5560His Glu His His His His Arg His Leu Ser Thr Ile Lys Glu Leu Leu 65 70 75 80Val Asn Ala Asp Ile Pro Glu Gln Thr Lys Gln Asp Ala Leu Gly Val

85 90 95Phe Glu Leu Ile Ala Ile Ala Glu Gly Lys Val His Gly Ile Glu Pro

100 105 110Glu Lys Ile His Phe His Glu Val Gly Ala Trp Asp Ser Ile Ala Asp

115 120 125Ile Val Gly Val Cys Glu Ala Ile Arg Gln Leu Asn Pro Gly Leu Ile

130 135 140Ala Ala Ser Pro Ile Ala Leu Gly Phe Gly Arg Ile Lys Ala Ala His145 150 155 160Gly Asp Ile Pro Val Pro Val Pro Ala Val Ala Glu Leu Val Lys Gly

165 170 175Trp Pro Thr Gln Thr Gly Ala Leu Met Glu Ser Thr Glu Pro Val Gly

180 185 190Glu Leu Ala Thr Pro Thr Gly Val Ala Leu Ile Arg His Phe Ala Thr

195 200 205Gln Asp Gly Pro Phe Pro Gly Gly Ile Ile Asn Glu Val Gly Ile Gly

210 215 220Ala Gly Thr Lys Asp Thr Glu Gly Arg Pro Asn Ile Val Arg Ala Ile225 230 235 240Leu Phe Asn Thr Ser Arg Ser Asn Pro Asp Thr Arg Thr Leu Val Gln

245 250 255Leu Glu Ala Asn Val Asp Asp Gln Asp Pro Arg Leu Trp Pro Gly Val

260 265 270Ile Glu Ile Leu Phe Ala Ala Gly Ala Val Asp Ala Trp Leu Thr Pro

275280 285Ile Leu Met Lys Lys Gly Arg Pro Ala His Arg Val Ser Ala Leu Val

290 295 300Asp Ser Ser Glu Val Glu Ala Val Lys Thr Ala Leu Phe Ala Ala Thr305 310 315 320Thr Thr Phe Gly Ile Arg Ser Trp Glu Val Glu Arg Glu Gly Leu Asp

325 330 335Arg Arg Phe Glu Gln Val Glu Val Asp Gly His Thr Ile Asn Ile Lys

340 345 350Ile Gly Ser Arg Asp Asp Gln Val Ile Ser Ala Gln Ser Glu Phe Glu

355 360 365Asp Ile Arg Ser Ala Ala Val Ala Leu Gly Ile Ser Glu Arg Glu Val

370375380 Val Ala Arg Ile Pro Gln Gly Thr Thr Glu 385390<210>1095<211>1419<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1396)<223>RXC02624<400>1095acccggtcag atccgacgtc gccggccaaa accgcaagca cctgcgcaaa cgccacagaa 60ggcagctcag caatcaaagt tgctgcgttt ccttccaacc gtg ctg att ccg cat 115

Val Leu Ile Pro His

1 5ggc gtg gcg gtg ctt ttg gtt att att ctc gcc gta gcc tcc cta atg 163Gly Val Ala Val Leu Leu Val Ile Ile Leu Ala Val Ala Ser Leu Met

10 15 20ttc acc aat tct tca atg gtg aat ctt tcg gca acg att gca cag ctg 211Phe Thr Asn Ser Ser Met Val Asn Leu Ser Ala Thr Ile Ala Gln Leu

25 30 35tgg ctt tcc cta aat ctc ggt gcg gtg gac ggc agt ggg gaa gtg atc 259Trp Leu Ser Leu Asn Leu Gly Ala Val Asp Gly Ser Gly Glu Val Ile

40 45 50tca gta ctg ccc acg ctt ccc ggc ttt ata ttc ctc tgg gcc atc gcc 307Ser Val Leu Pro Thr Leu Pro Gly Phe Ile Phe Leu Trp Ala Ile Ala

55 60 65gcg cgc atc cac cgc gca gtc aaa gat cgt gtc agc atc gcc gac tta 355Ala Arg Ile His Arg Ala Val Lys Asp Arg Val Ser Ile Ala Asp Leu 70 75 80 85ggc gtc ctc gca gca ctc gtc ctc ggc atc ccg ctt gcg ctc acc gcc 403Gly Val Leu Ala Ala Leu Val Leu Gly Ile Pro Leu Ala Leu Thr Ala

90 95 100atc gca gcg ttc atg ctt ttc gac gcc tcc agc gtc ctc aac gtc gag 451Ile Ala Ala Phe Met Leu Phe Asp Ala Ser Ser Val Leu Asn Val Glu

105 110 115gtc ccg cca atc acg cgc ctc cta cgc gtg atg ttg ttc cac ctc agc 499Val Pro Pro Ile Thr Arg Leu Leu Arg Val Met Leu Phe His Leu Ser

120 125 130gcc ctc ttc ctc ggc atg ggg cca cgc ctg tgg cag gcg ttg gcg cgc 547Ala Leu Phe Leu Gly Met Gly Pro Arg Leu Trp Gln Ala Leu Ala Arg

135 140 145cgc tac ggt gct cca gaa tgg ctt atc gac gcc atc acc caa gct ttc 595Arg Tyr Gly Ala Pro Glu Trp Leu Ile Asp Ala Ile Thr Gln Ala Phe150 155 160 165cgc ttc ctc atc gca ttt gga aca gtc tcc ttg gtt tcc gtg ctc gtg 643Arg Phe Leu Ile Ala Phe Gly Thr Val Ser Leu Val Ser Val Leu Val

170 175 180atg acc gcg atc aac cac agt gca ttc acc gcg acc atg cag ggt tac 691Met Thr Ala Ile Asn His Ser Ala Phe Thr Ala Thr Met Gln Gly Tyr

185 190 195gac gac tccgcc tct gtt gtg gcc ttg atc gtc ctg agc att ctg tat 739Asp Asp Ser Ala Ser Val Val Ala Leu Ile Val Leu Ser Ile Leu Tyr

200 205 210ctg ccc aac atg atg atc ttt gcg atg ggc aat ctg atc ggc tca ccc 787Leu Pro Asn Met Met Ile Phe Ala Met Gly Asn Leu Ile Gly Ser Pro

215 220 225ctt tac ttc ggt gac gcc tcc atc agc gtc ttc agc gtg cat tcc gtt 835Leu Tyr Phe Gly Asp Ala Ser Ile Ser Val Phe Ser Val His Ser Val230 235 240 245cca ttg cca ccg ctt ccc atc ctc gca gct ctc ccc agc gaa gcc ctc 883Pro Leu Pro Pro Leu Pro Ile Leu Ala Ala Leu Pro Ser Glu Ala Leu

250 255 260tca tgg gca gtg gcc tta ctg gtc atc cct gca att att gcc acc tgg 931Ser Trp Ala Val Ala Leu Leu Val Ile Pro Ala Ile Ile Ala Thr Trp

265 270 275gtc tgc gtg aga aac ccc atg cgc ctt gcc gtg aac aca aca gca gca 979Val Cys Val Arg Asn Pro Met Arg Leu Ala Val Asn Thr Thr Ala Ala

280 285 290gtc att tca gca ctg tgt ttc ctc gtc ctg gca gtt ttc gcc ggc gga 1027Val Ile Ser Ala Leu Cys Phe Leu Val Leu Ala Val Phe Ala Gly Gly

295 300 305acc ttg ggc gta tac aac tac gtc gga ctc aac ctc ctg gcg tca gtt 1075Thr Leu Gly Val Tyr Asn Tyr Val Gly Leu Asn Leu Leu Ala Ser Val310 315 320 325ggc cta gtt ttc gtc tat ttc gcc ctc gtt gga ctc ctc atc gcc gga 1123Gly Leu Val Phe Val Tyr Phe Ala Leu Val Gly Leu Leu Ile Ala Gly

330 335 340atc gac aag ctg cgc aac cct gta gaa gtt aag tct gtt aag gct gtg 1171Ile Asp Lys Leu Arg Asn Pro Val Glu Val Lys Ser Val Lys Ala Val

345 350 355gct gtt gtg gag ccc gag cct gaa gaa gtt gaa gag gac gaa gag gag 1219Ala Val Val Glu Pro Glu Pro Glu Glu Val Glu Glu Asp Glu Glu Glu

360 365 370cat gtt gaa gaa gaa gta gat gag gag gaa gag gaa gtt gag gaa ggg 1267His Val Glu Glu Glu Val Asp Glu Glu Glu Glu Glu Val Glu Glu Gly

375 380 385gta gaa gag gtc gaa gaa gac gac gca gag gat cct gaa gag aat cct 1315Val Glu Glu Val Glu Glu Asp Asp Ala Glu Asp Pro Glu Glu Asn Pro390 395 400 405gaa gag gaa gaa tcc gac gaa gaa att gag aca gaa act gag gct gaa 1363Glu Glu Glu Glu Ser Asp Glu Glu Ile Glu Thr Glu Thr Glu Ala Glu

410 415 420gaa acc aat gat ggt tcc gag gcc gaa gac cgt taacatatct gttgtgaatt 1416Glu Thr Asn Asp Gly Ser Glu Ala Glu Asp Arg

425430 ctg 1419<210>1096<211>432<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1096Val Leu Ile Pro His Gly Val Ala Val Leu Leu Val Ile Ile Leu Ala 151015 Val Ala Ser Leu Met Phe Thr Asn Ser Ser Met Val Asn Leu Ser Ala

20 25 30Thr Ile Ala Gln Leu Trp Leu Ser Leu Asn Leu Gly Ala Val Asp Gly

35 40 45Ser Gly Glu Val Ile Ser Val Leu Pro Thr Leu Pro Gly Phe Ile Phe

50 55 60Leu Trp Ala Ile Ala Ala Arg Ile His Arg Ala Val Lys Asp Arg Val 65 70 75 80Ser Ile Ala Asp Leu Gly Val Leu Ala Ala Leu Val Leu Gly Ile Pro

85 90 95Leu Ala Leu Thr Ala Ile Ala Ala Phe Met Leu Phe Asp Ala Ser Ser

100 105 110Val Leu Asn Val Glu Val Pro Pro Ile Thr Arg Leu Leu Arg Val Met

115 120 125Leu Phe His Leu Ser Ala Leu Phe Leu Gly Met Gly Pro Arg Leu Trp

130 135 140Gln Ala Leu Ala Arg Arg Tyr Gly Ala Pro Glu Trp Leu Ile Asp Ala145 150 155 160Ile Thr Gln Ala Phe Arg Phe Leu Ile Ala Phe Gly Thr Val Ser Leu

165 170 175Val Ser Val Leu Val Met Thr Ala Ile Asn His Ser Ala Phe Thr Ala

180 185 190Thr Met Gln Gly Tyr Asp Asp Ser Ala Ser Val Val Ala Leu Ile Val

195 200 205Leu Ser Ile Leu Tyr Leu Pro Asn Met Met Ile Phe Ala Met Gly Asn

210 215 220Leu Ile Gly Ser Pro Leu Tyr Phe Gly Asp Ala Ser Ile Ser Val Phe225 230 235 240Ser Val His Ser Val Pro Leu Pro Pro Leu Pro Ile Leu Ala Ala Leu

245 250 255Pro Ser Glu Ala Leu Ser Trp Ala Val Ala Leu Leu Val Ile Pro Ala

260 265 270Ile Ile Ala Thr Trp Val Cys Val Arg Asn Pro Met Arg Leu Ala Val

275 280 285Asn Thr Thr Ala Ala Val Ile Ser Ala Leu Cys Phe Leu Val Leu Ala

290 295 300Val Phe Ala Gly Gly Thr Leu Gly Val Tyr Asn Tyr Val Gly Leu Asn305 310 315320Leu Leu Ala Ser Val Gly Leu Val Phe Val Tyr Phe Ala Leu Val Gly

325 330 335Leu Leu Ile Ala Gly Ile Asp Lys Leu Arg Asn Pro Val Glu Val Lys

340 345 350Ser Val Lys Ala Val Ala Val Val Glu Pro Glu Pro Glu Glu Val Glu

355 360 365Glu Asp Glu Glu Glu His Val Glu Glu Glu Val Asp Glu Glu Glu Glu

370 375 380Glu Val Glu Glu Gly Val Glu Glu Val Glu Glu Asp Asp Ala Glu Asp385 390 395 400Pro Glu Glu Asn Pro Glu Glu Glu Glu Ser Asp Glu Glu Ile Glu Thr

405 410 415Glu Thr Glu Ala Glu Glu Thr Asn Asp Gly Ser Glu Ala Glu Asp Arg

420425430<210>1097<211>603<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (580)<223>RXC02665<400>1097caaggcgacc caatggcgtt taaagtaaca acccccattg atatgatgct ggcacaacgc 60atcaccgacg aagccgaacc cacaatattt gaggtaccag gtg act aac cca atc 115

Val Thr Asn Pro Ile

1 5atc ccc cgc gta gga atc gcc aca gac gcc cac caa atc gaa gcg gga 163Ile Pro Arg Val Gly Ile Ala Thr Asp Ala His Gln Ile Glu Ala Gly

10 15 20aaa ccc tgc tgg atc gcc tgc ctc ctc ttt gaa ggc gtc gac ggc tgc 211Lys Pro Cys Trp Ile Ala Cys Leu Leu Phe Glu Gly Val Asp Gly Cys

25 30 35gaa ggc cac tcc gac ggt gat gtt gta gct cat gca att gtg gat gct 259Glu Gly His Ser Asp Gly Asp Val Val Ala His Ala Ile Val Asp Ala

40 45 50ctc ctt tct gcc tct ggt ctg ggg gat ttg ggc tct ttc gtt ggt gtg 307Leu Leu Ser Ala Ser Gly Leu Gly Asp Leu Gly Ser Phe Val Gly Val

55 60 65ggg aga cct gaa tac gat ggt gtt tct ggt aca cag ttg ttg aag gaa 355Gly Arg Pro Glu Tyr Asp Gly Val Ser Gly Thr Gln Leu Leu Lys Glu 70 75 80 85gtt cgg gag ctg ctt tcg gca cac ggg tac gtc att gga aat gtc gcc 403Val Arg Glu Leu Leu Ser Ala His Gly Tyr Val Ile Gly Asn Val Ala

90 95 100gcc caa ctg gtt ggc caa acc ccc aaa ttt gga ccc cgc cgc gaa gaa 451Ala Gln Leu Val Gly Gln Thr Pro Lys Phe Gly Pro Arg Arg Glu Glu

105 110 115gca caa caa gtc atc tcc gaa atc atc ggc gca cca tgc tca ctg tct 499Ala Gln Gln Val Ile Ser Glu Ile Ile Gly Ala Pro Cys Ser Leu Ser

120 125 130gcc acc acc act gat cac atg gga ttc act ggt cgc agc gag ggt cgt 547Ala Thr Thr Thr Asp His Met Gly Phe Thr Gly Arg Ser Glu Gly Arg

135140145 gca tcg gta gca acg gca gtg gtg tgg aag gct taagttttct gtagggattg 600Ala Ser Val Ala Thr Ala Val Val Trp Lys Ala 150155160 ggc 603<210>1098<211>160<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1098Val Thr Asn Pro Ile Ile Pro Arg Val Gly Ile Ala Thr Asp Ala His 151015 Gln Ile Glu Ala Gly Lys Pro Cys Trp Ile Ala Cys Leu Leu Phe Glu

20 25 30Gly Val Asp Gly Cys Glu Gly His Ser Asp Gly Asp Val Val Ala His

35 40 45Ala Ile Val Asp Ala Leu Leu Ser Ala Ser Gly Leu Gly Asp Leu Gly

50 55 60Ser Phe Val Gly Val Gly Arg Pro Glu Tyr Asp Gly Val Ser Gly Thr 65 70 75 80Gln Leu Leu Lys Glu Val Arg Glu Leu Leu Ser Ala His Gly Tyr Val

85 90 95Ile Gly Asn Val Ala Ala Gln Leu Val Gly Gln Thr Pro Lys Phe Gly

100 105 110Pro Arg Arg Glu Glu Ala Gln Gln Val Ile Ser Glu Ile Ile Gly Ala

115 120 125Pro Cys Ser Leu Ser Ala Thr Thr Thr Asp His Met Gly Phe Thr Gly

130135140 Arg Ser Glu Gly Arg Ala Ser Val Ala Thr Ala Val Val Trp Lys Ala 145150155160<210>1099<211>1689<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1666)<223>RXC02770<400>1099tcgccggggc aaaaaccgta taattacagt cctattacga ttcggggaaa ggctgggtac 60ttcacacatg ttgtttcgga agtcacgcag cgcggtaatc atg ttg gtt gca gcg 115

Met Leu Val Ala Ala

1 5tta gtg atg aca agc tgt ggt gat ggg gaa ccg gaa cca acc agc cac 163Leu Val Met Thr Ser Cys Gly Asp Gly Glu Pro Glu Pro Thr Ser His

10 15 20caa aca agc ctt ttc ggc tac gca gtt aac tct tcg ctg gct aca acc 211Gln Thr Ser Leu Phe Gly Tyr Ala Val Asn Ser Ser Leu Ala Thr Thr

25 30 35aac gcg gcg tcg ctg ttg gga gtg gct aat gat gct ggt ctt ttg gct 259Asn Ala Ala Ser Leu Leu Gly Val Ala Asn Asp Ala Gly Leu Leu Ala

40 45 50gcc aga gtg tat ccg ggt gtg tat gtt cag ggt cct tct ggg cag atg 307Ala Arg Val Tyr Pro Gly Val Tyr Val Gln Gly Pro Ser Gly Gln Met

55 60 65att ccc aac act gat ctt gct tcc acg cag gta ttg ccg ggt att aac 355Ile Pro Asn Thr Asp Leu Ala Ser Thr Gln Val Leu Pro Gly Ile Asn 70 75 80 85cgc cag gtg att tac act atc aat gaa gat gcc acc tac tca gat ggt 403Arg Gln Val Ile Tyr Thr Ile Asn Glu Asp Ala Thr Tyr Ser Asp Gly

90 95 100cag cct gtg gtg tgt gat gat ttt ctg ctc tct gcg aca gct ggg cag 451Gln Pro Val Val Cys Asp Asp Phe Leu Leu Ser Ala Thr Ala Gly Gln

105 110 115atg ccg gaa ctg ttc cag tcc cat gtg cca ttg acc tcg cag att gag 499Met Pro Glu Leu Phe Gln Ser His Val Pro Leu Thr Ser Gln Ile Glu

120 125 130cga gtg gac tgt gta tct ggt tct aaa gta gcc acc gtg gtg ttc aag 547Arg Val Asp Cys Val Ser Gly Ser Lys Val Ala Thr Val Val Phe Lys

135 140 145gaa gac ctc ggt gag cgt tgg cgt tat ctt ttt gag cag ggc gat ttg 595Glu Asp Leu Gly Glu Arg Trp Arg Tyr Leu Phe Glu Gln Gly Asp Leu150 155 160 165ttg cca gcc cat gcc gtt gct tcc aaa gca ggt atg acc ttg gag gag 643Leu Pro Ala His Ala Val Ala Ser Lys Ala Gly Met Thr Leu Glu Glu

170 175 180ctt aat cag gcg ttg aag gat aag gat cct gaa gcg ttg act gaa cct 691Leu Asn Gln Ala Leu Lys Asp Lys Asp Pro Glu Ala Leu Thr Glu Pro

185 190 195gct cgt gtg tgg agc gaa ggt ttc cag ctg tcc cag ttt gat cca gag 739Ala Arg Val Trp Ser Glu Gly Phe Gln Leu Ser Gln Phe Asp Pro Glu

200 205 210ctg cag acg gct ttt ggc ccg tac aag gtg gat tct gtg ggt gaa ttc 787Leu Gln Thr Ala Phe Gly Pro Tyr Lys Val Asp Ser Val Gly Glu Phe

215 220 225ggc gaa gtc aag ctg gta cgc aat gag ttt tac agt ggc gac cag gcg 835Gly Glu Val Lys Leu Val Arg Asn Glu Phe Tyr Ser Gly Asp Gln Ala230 235 240 245gtt gaa gca gaa atc acg atg tgg cct aaa ggc tcg gat ctc agc gcc 883Val Glu Ala Glu Ile Thr Met Trp Pro Lys Gly Ser Asp Leu Ser Ala

250 255 260att gcg gat aat gga aac ctt cag ate gca cat gtt gtg gcg tgg gag 931Ile Ala Asp Asn Gly Asn Leu Gln Ile Ala His Val Val Ala Trp Glu

265 270 275agc gag ccg tgg gta aat cgc gat gac cca ttg aat cct tat gac att 979Ser Glu Pro Trp Val Asn Arg Asp Asp Pro Leu Asn Pro Tyr Asp Ile

280 285 290aag gaa gag gtc ggt gtt ttg act gag cag ctc acc ttg gcc agt gcc 1027Lys Glu Glu Val Gly Val Leu Thr Glu Gln Leu Thr Leu Ala Ser Ala

295 300 305ggt gtg ttt tac gct gcg gag gcc cgg cag gcg ttt gcg gcc tgc gtt 1075Gly Val Phe Tyr Ala Ala Glu Ala Arg Gln Ala Phe Ala Ala Cys Val310 315 320 325gac cag gaa gcg gtg gct gcg gcg tcg tca agc atc tct gga atc gat 1123Asp Gln Glu Ala Val Ala Ala Ala Ser Ser Ser Ile Ser Gly Ile Asp

330 335 340gtg cct gcc gta ggt gtgcac tcg gtg cgt cac caa aat ccg gtc gtg 1171Val Pro Ala Val Gly Val His Ser Val Arg His Gln Asn Pro Val Val

345 350 355cac caa atc ggt gat ctg cca gca cag cac atg gcg gtg gat att aat 1219His Gln Ile Gly Asp Leu Pro Ala Gln His Met Ala Val Asp Ile Asn

360 365 370gcc gca tca gcg ttg gcg ggt caa tcc atc cgc att ggc tac gac gga 1267Ala Ala Ser Ala Leu Ala Gly Gln Ser Ile Arg Ile Gly Tyr Asp Gly

375 380 385ccc gat gag cgc aag gct gca atg gtg gag gcg att cgc caa agt tgt 1315Pro Asp Glu Arg Lys Ala Ala Met Val Glu Ala Ile Arg Gln Ser Cys390 395 400 405gag cct gcc ggt atc acc gtt atc gat gcg tcg cag gag gct gtt agt 1363Glu Pro Ala Gly Ile Thr Val Ile Asp Ala Ser Gln Glu Ala Val Ser

410 415 420ctt aat gat ctc agt cga acc gaa gtc agt gaa tgg ggc tat gag cag 1411Leu Asn Asp Leu Ser Arg Thr Glu Val Ser Glu Trp Gly Tyr Glu Gln

425 430 435tac ttc gaa ggg aca ctt gac gct gtt ctg cgt aca gtg gat cca cat 1459Tyr Phe Glu Gly Thr Leu Asp Ala Val Leu Arg Thr Val Asp Pro His

440 445 450cgg gag tat gaa aat gcc aat acc att gga act gat gcg gag tcg acg 1507Arg Glu Tyr Glu Asn Ala Asn Thr Ile Gly Thr Asp Ala Glu Ser Thr

455 460 465agg cgc act gaa gaa caa ttg tgg gct gaa gtc cca tca att cca cta 1555Arg Arg Thr Glu Glu Gln Leu Trp Ala Glu Val Pro Ser Ile Pro Leu470 475 480 485gca gcg caa ccc cga gtg ttt gtg ata gat cgc aca gtc ggt aac gtt 1603Ala Ala Gln Pro Arg Val Phe Val Ile Asp Arg Thr Val Gly Asn Val

490 495 500gtt gtt aat aca gac cta gcc ggt atc gga tgg aac atg gac cgt tgg 1651Val Val Asn Thr Asp Leu Ala Gly Ile Gly Trp Asn Met Asp Arg Trp

505 510 515tcc aga agt gag gaa taagtagtga gcgaacaagc tct 1689Ser Arg Ser Glu Glu

520<210>1100<211>522<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1100Met Leu Val Ala Ala Leu Val Met Thr Ser Cys Gly Asp Gly Glu Pro 151015 Glu Pro Thr Ser His Gln Thr Ser Leu Phe Gly Tyr Ala Val Asn Ser

20 25 30Ser Leu Ala Thr Thr Asn Ala Ala Ser Leu Leu Gly Val Ala Asn Asp

35 40 45Ala Gly Leu Leu Ala Ala Arg Val Tyr Pro Gly Val Tyr Val Gln Gly

50 55 60Pro Ser Gly Gln Met Ile Pro Asn Thr Asp Leu Ala Ser Thr Gln Val 65 70 75 80Leu Pro Gly Ile Asn Arg Gln Val Ile Tyr Thr Ile Asn Glu Asp Ala

85 90 95Thr Tyr Ser Asp Gly Gln Pro Val Val Cys Asp Asp Phe Leu Leu Ser

100 105 110Ala Thr Ala Gly Gln Met Pro Glu Leu Phe Gln Ser His Val Pro Leu

115 120 125Thr Ser Gln Ile Glu Arg Val Asp Cys Val Ser Gly Ser Lys Val Ala

130 135 140Thr Val Val Phe Lys Glu Asp Leu Gly Glu Arg Trp Arg Tyr Leu Phe145 150 155 160Glu Gln Gly Asp Leu Leu Pro Ala His Ala Val Ala Ser Lys Ala Gly

165 170 175Met Thr Leu Glu Glu Leu Asn Gln Ala Leu Lys Asp Lys Asp Pro Glu

180 185 190Ala Leu Thr Glu Pro Ala Arg Val Trp Ser Glu Gly Phe Gln Leu Ser

195 200 205Gln Phe Asp Pro Glu Leu Gln Thr Ala Phe Gly Pro Tyr Lys Val Asp

210 215 220Ser Val Gly Glu Phe Gly Glu Val Lys Leu Val Arg Asn Glu Phe Tyr225 230 235 240Ser Gly Asp Gln Ala Val Glu Ala Glu Ile Thr Met Trp Pro Lys Gly

245 250 255Ser Asp Leu Ser Ala Ile Ala Asp Asn Gly Asn Leu Gln Ile Ala His

260 265 270Val Val Ala Trp Glu Ser Glu Pro Trp Val Asn Arg Asp Asp Pro Leu

275 280 285Asn Pro Tyr Asp Ile Lys Glu Glu Val Gly Val Leu Thr Glu Gln Leu

290 295 300Thr Leu Ala Ser Ala Gly Val Phe Tyr Ala Ala Glu Ala Arg Gln Ala305 310 315 320Phe Ala Ala Cys Val Asp Gln Glu Ala Val Ala Ala Ala Ser Ser Ser

325 330 335Ile Ser Gly Ile Asp Val Pro Ala Val Gly Val His Ser Val Arg His

340 345 350Gln Asn Pro Val Val His Gln Ile Gly Asp Leu Pro Ala Gln His Met

355 360 365Ala Val Asp Ile Asn Ala Ala Ser Ala Leu Ala Gly Gln Ser Ile Arg

370 375 380Ile Gly Tyr Asp Gly Pro Asp Glu Arg Lys Ala Ala Met Val Glu Ala385 390 395 400Ile Arg Gln Ser Cys Glu Pro Ala Gly Ile Thr Val Ile Asp Ala Ser

405 410 415Gln Glu Ala Val Ser Leu Asn Asp Leu Ser Arg Thr Glu Val Ser Glu

420 425 430Trp Gly Tyr Glu Gln Tyr Phe Glu Gly Thr Leu Asp Ala Val Leu Arg

435 440 445Thr Val Asp Pro His Arg Glu Tyr Glu Asn Ala Asn Thr Ile Gly Thr

450 455 460Asp Ala Glu Ser Thr Arg Arg Thr Glu Glu Gln Leu Trp Ala Glu Val465 470 475 480Pro Ser Ile Pro Leu Ala Ala Gln Pro Arg Val Phe Val Ile Asp Arg

485 490 495Thr Val Gly Asn Val Val Val Asn Thr Asp Leu Ala Gly Ile Gly Trp

500 505 510Asn Met Asp Arg Trp Ser Arg Ser Glu Glu

515520<210>1101<211>408<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (385)<223>RXC02238<400>1101ggcgcttagc caaaacatag agcggtaggg tatgcttatc cgattgagca acctttcccg 60ctcttaacac tactgtccat atacttttga aaaggtgtca gtg acc aac gtg agc 115

Val Thr Asn Val Ser

1 5aac gag acc aac gcc acc aag gcc gtc ttc gat ccg cca gtg ggc att 163Asn Glu Thr Asn Ala Thr Lys Ala Val Phe Asp Pro Pro Val Gly Ile

10 15 20acc gct cct ccg atc gat gaa ctg ctg gat aag gtc act tcc aag tac 211Thr Ala Pro Pro Ile Asp Glu Leu Leu Asp Lys Val Thr Ser Lys Tyr

25 30 35gcc ctc gtg atc ttc gca gcc aag cgt gcg cgc cag atc aac agc ttc 259Ala Leu Val Ile Phe Ala Ala Lys Arg Ala Arg Gln Ile Asn Ser Phe

40 45 50tac cat cag gca gat gag gga gta ttc gag ttc atc gga cca ttg gtt 307Tyr His Gln Ala Asp Glu Gly Val Phe Glu Phe Ile Gly Pro Leu Val

55 60 65act ccg cag cca ggc gaa aag cca ctt tct att gct ctg cgt gag atc 355Thr Pro Gln Pro Gly Glu Lys Pro Leu Ser Ile Ala Leu Arg Glu Ile 70 75 80 85aat gca ggt ctg ttg gac cac gag gaa ggt taaaagacct tataacttca 405Asn Ala Gly Leu Leu Asp His Glu Glu Gly

9095 cac 408<210>1102<211>95<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1102Val Thr Asn Val Ser Asn Glu Thr Asn Ala Thr Lys Ala Val Phe Asp 151015 Pro Pro Val Gly Ile Thr Ala Pro Pro Ile Asp Glu Leu Leu Asp Lys

20 25 30Val Thr Ser Lys Tyr Ala Leu Val Ile Phe Ala Ala Lys Arg Ala Arg

35 40 45Gln Ile Asn Ser Phe Tyr His Gln Ala Asp Glu Gly Val Phe Glu Phe

50 55 60Ile Gly Pro Leu Val Thr Pro Gln Pro Gly Glu Lys Pro Leu Ser Ile 65 70 75 80Ala Leu Arg Glu Ile Asn Ala Gly Leu Leu Asp His Glu Glu Gly

859095<210>1103<211>1298<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) } (1275)<223>RXC01946<400>1103atc cgc aag tac tcc agg ctc gag gaa caa ttc cag tcg ctc ggc ggc 48Ile Arg Lys Tyr Ser Arg Leu Glu Glu Gln Phe Gln Ser Leu Gly Gly 151015 tac gaa gct gac gcc gaa gca gcc cag atc tgc gac aac ctc ggc ctc 96Tyr Glu Ala Asp Ala Glu Ala Ala Gln Ile Cys Asp Asn Leu Gly Leu

20 25 30gag gca cgc atc ctc gac cag cag ctt aaa acc ctg tcc ggc ggc cag 144Glu Ala Arg Ile Leu Asp Gln Gln Leu Lys Thr Leu Ser Gly Gly Gln

35 40 45cgc cgc cgc gtc gag ttg gcg cag atc ctc ttc gcc gcc acc aac ggc 192Arg Arg Arg Val Glu Leu Ala Gln Ile Leu Phe Ala Ala Thr Asn Gly

50 55 60tcc ggc aaa tca aaa acc aca ttg ctt ctc gac gag ccc acc aac cac 240Ser Gly Lys Ser Lys Thr Thr Leu Leu Leu Asp Glu Pro Thr Asn His 65 70 75 80ttg gac gca gac tcg atc acc tgg ctc cgt gac ttc ctg gcg aag cac 288Leu Asp Ala Asp Ser Ile Thr Trp Leu Arg Asp Phe Leu Ala Lys His

85 90 95gaa ggt gga ctg atc atg att tcg cac gac gtc gaa ctg ctt ggc gcc 336Glu Gly Gly Leu Ile Met Ile Ser His Asp Val Glu Leu Leu Gly Ala

100 105 110gta tgt aac aag att tgg tac ctc gac gca gta cgc agc gaa gcc gat 384Val Cys Asn Lys Ile Trp Tyr Leu Asp Ala Val Arg Ser Glu Ala Asp

115 120 125gtc tac aac atg ggc ttt agc aaa tac gtc gat gca cgt gca ctc gat 432Val Tyr Asn Met Gly Phe Ser Lys Tyr Val Asp Ala Arg Ala Leu Asp

130 135 140gaa gca cgc cga cgc cgt gag cgc gca aac gcc gaa aag aag gcc gga 480Glu Ala Arg Arg Arg Arg Glu Arg Ala Asn Ala Glu Lys Lys Ala Gly145 150155 160gcc ctc aag gac cag gct gca cgc ctc ggc gcg aaa gca acc aag gct 528Ala Leu Lys Asp Gln Ala Ala Arg Leu Gly Ala Lys Ala Thr Lys Ala

165 170 175gcc gca gct aag cag atg atc gcc cgt gcg gaa cga atg atc gac aac 576Ala Ala Ala Lys Gln Met Ile Ala Arg Ala Glu Arg Met Ile Asp Asn

180 185 190ctc gac gaa atc cgc gta gct gac cgc gcc gcc aac atc gtt ttc cca 624Leu Asp Glu Ile Arg Val Ala Asp Arg Ala Ala Asn Ile Val Phe Pro

195 200 205gaa cca gca ccc tgt gga aaa acc cca ctc aac gcc aag ggc ctg acc 672Glu Pro Ala Pro Cys Gly Lys Thr Pro Leu Asn Ala Lys Gly Leu Thr

210 215 220aag atg tac ggc tcc ctc gaa gtc ttc gcc ggc gtc gac cta gcc atc 720Lys Met Tyr Gly Ser Leu Glu Val Phe Ala Gly Val Asp Leu Ala Ile225 230 235 240gac aaa ggc tcc cgc gta gtc gtc ctc gga ttc aac ggt gca ggt aaa 768Asp Lys Gly Ser Arg Val Val Val Leu Gly Phe Asn Gly Ala Gly Lys

245 250 255acc acc ctg ctc aaa ctc ctc gcc ggt gtg gaa cgc acc gac ggc gaa 816Thr Thr Leu Leu Lys Leu Leu Ala Gly Val Glu Arg Thr Asp Gly Glu

260 265 270ggc ggc atc gtc acc gga tac ggc ctc aaa atc ggc tac ttc gcc cag 864Gly Gly Ile Val Thr Gly Tyr Gly Leu Lys Ile Gly Tyr Phe Ala Gln

275 280 285gaa cac gac acc atc gac ccc gac aaa tcc gtc tgg caa aac acc atc 912Glu His Asp Thr Ile Asp Pro Asp Lys Ser Val Trp Gln Asn Thr Ile

290 295 300gaa gcc tgc gcc gac gcc gac caa caaagc ctc cgc agc ctc ctc gga 960Glu Ala Cys Ala Asp Ala Asp Gln Gln Ser Leu Arg Ser Leu Leu Gly305 310 315 320tcc ttc atg ttc tcc ggc gaa caa ctc gac caa cca gca gga aca ctc 1008Ser Phe Met Phe Ser Gly Glu Gln Leu Asp Gln Pro Ala Gly Thr Leu

325 330 335tcc ggc ggt gaa aaa acc cgc ctc gca ctg gcc acc ctc gtg tcc tcc 1056Ser Gly Gly Glu Lys Thr Arg Leu Ala Leu Ala Thr Leu Val Ser Ser

340 345 350cgc gca aac gtc ctg ctt ctc gac gag ccc acc aac aac ctt gac ccg 1104Arg Ala Asn Val Leu Leu Leu Asp Glu Pro Thr Asn Asn Leu Asp Pro

355 360 365atc tcc cgc gaa cag gtc ctc gac gca ctg cgc acc tac acc ggc gca 1152Ile Ser Arg Glu Gln Val Leu Asp Ala Leu Arg Thr Tyr Thr Gly Ala

370 375 380gtc gtc ctg gtt acc cac gac ccg ggt gca gtc aag gcc ctt gag cca 1200Val Val Leu Val Thr His Asp Pro Gly Ala Val Lys Ala Leu Glu Pro385 390 395 400gaa cgc gtc atc gtg ctt cct gat ggc acc gag gat ctt tgg aat gat 1248Glu Arg Val Ile Val Leu Pro Asp Gly Thr Glu Asp Leu Trp Asn Asp

405 410 415cag tac atg gaa atc gtg gaa ttg gcg taggttctaa ggctgtttat 1295Gln Tyr Met Glu Ile Val Glu Leu Ala

420425 gct 1298<210>1104<211>425<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1104Ile Arg Lys Tyr Ser Arg Leu Glu Glu Gln Phe Gln Ser Leu Gly Gly 151015 Tyr Glu Ala Asp Ala Glu Ala Ala Gln Ile Cys Asp Asn Leu Gly Leu

20 25 30Glu Ala Arg Ile Leu Asp Gln Gln Leu Lys Thr Leu SerGly Gly Gln

35 40 45Arg Arg Arg Val Glu Leu Ala Gln Ile Leu Phe Ala Ala Thr Asn Gly

50 55 60Ser Gly Lys Ser Lys Thr Thr Leu Leu Leu Asp Glu Pro Thr Asn His 65 70 75 80Leu Asp Ala Asp Ser Ile Thr Trp Leu Arg Asp Phe Leu Ala Lys His

85 90 95Glu Gly Gly Leu Ile Met Ile Ser His Asp Val Glu Leu Leu Gly Ala

100 105 110Val Cys Asn Lys Ile Trp Tyr Leu Asp Ala Val Arg Ser Glu Ala Asp

115 120 125Val Tyr Asn Met Gly Phe Ser Lys Tyr Val Asp Ala Arg Ala Leu Asp

130 135 140Glu Ala Arg Arg Arg Arg Glu Arg Ala Asn Ala Glu Lys Lys Ala Gly145 150 155 160Ala Leu Lys Asp Gln Ala Ala Arg Leu Gly Ala Lys Ala Thr Lys Ala

165 170 175Ala Ala Ala Lys Gln Met Ile Ala Arg Ala Glu Arg Met Ile Asp Asn

180 185 190Leu Asp Glu Ile Arg Val Ala Asp Arg Ala Ala Asn Ile Val Phe Pro

195 200 205Glu Pro Ala Pro Cys Gly Lys Thr Pro Leu Asn Ala Lys Gly Leu Thr

210 215 220Lys Met Tyr Gly Ser Leu Glu Val Phe Ala Gly Val Asp Leu Ala Ile225 230 235 240Asp Lys Gly Ser Arg Val Val Val Leu Gly Phe Asn Gly Ala Gly Lys

245 250 255Thr Thr Leu Leu Lys Leu Leu Ala Gly Val Glu ArgThr Asp Gly Glu

260 265 270Gly Gly Ile Val Thr Gly Tyr Gly Leu Lys Ile Gly Tyr Phe Ala Gln

275 280 285Glu His Asp Thr Ile Asp Pro Asp Lys Ser Val Trp Gln Asn Thr Ile

290 295 300Glu Ala Cys Ala Asp Ala Asp Gln Gln Ser Leu Arg Ser Leu Leu Gly305 310 315 320Ser Phe Met Phe Ser Gly Glu Gln Leu Asp Gln Pro Ala Gly Thr Leu

325 330 335Ser Gly Gly Glu Lys Thr Arg Leu Ala Leu Ala Thr Leu Val Ser Ser

340 345 350Arg Ala Asn Val Leu Leu Leu Asp Glu Pro Thr Asn Asn Leu Asp Pro

355 360 365Ile Ser Arg Glu Gln Val Leu Asp Ala Leu Arg Thr Tyr Thr Gly Ala

370 375 380Val Val Leu Val Thr His Asp Pro Gly Ala Val Lys Ala Leu Glu Pro385 390 395 400Glu Arg Val Ile Val Leu Pro Asp Gly Thr Glu Asp Leu Trp Asn Asp

405 410 415Gln Tyr Met Glu Ile Val Glu Leu Ala

420425<210>1105<211>613<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (613)<223>RXN03171<400>1105atactttgtt ggactggaaa agtggccgtt tggttccctc caagcccaaa ttcgcccgcg 60cggtcttctt ctgggcggca atgatttaac atgtgaagct atg gac atc acc atc 115

Met Asp Ile Thr Ile

1 5gtc aac cac cca ctc gtt gct agc cgc cta acc ctg ttg cgc gac gag 163Val Asn His Pro Leu Val Ala Ser Arg Leu Thr Leu Leu Arg Asp Glu

10 15 20cgc agc gac aac gca gct ttc cgt gca gca gcc aac gac ctc ggc gcc 211Arg Ser Asp Asn Ala Ala Phe Arg Ala Ala Ala Asn Asp Leu Gly Ala

25 30 35atg ctg atc tac gaa gca tcc cga gat ctg gaa gtc gaa cac ttc gac 259Met Leu Ile Tyr Glu Ala Ser Arg Asp Leu Glu Val Glu His Phe Asp

40 45 50acc aaa acc ccc gtt gcc atg gct gaa ggt act cgc ctg aag cag cca 307Thr Lys Thr Pro Val Ala Met Ala Glu Gly Thr Arg Leu Lys Gln Pro

55 60 65ccc atc atc gtt ccc atc atc cgt gca ggt ctc ggc atg atc gac cca 355Pro Ile Ile Val Pro Ile Ile Arg Ala Gly Leu Gly Met Ile Asp Pro 70 75 80 85gcg ctg tcg atg att ccg gat gca cag gtc ggc ttc att ggc ctt gcc 403Ala Leu Ser Met Ile Pro Asp Ala Gln Val Gly Phe Ile Gly Leu Ala

90 95 100cgc gat gag gaa acc cat gag cca gtc cca tac ctt gag gcg ctg cca 451Arg Asp Glu Glu Thr His Glu Pro Val Pro Tyr Leu Glu Ala Leu Pro

105 110 115cag gat cta agc aac cag cct gta ttc ctt gtc gat ccc atg ctg gcc 499Gln Asp Leu Ser Asn Gln Pro Val Phe Leu Val Asp Pro Met Leu Ala

120 125 130acc ggc ggt tcc ctc ctg cac gcg atc cgc ctt ctt gct gat cgt ggc 547Thr Gly Gly Ser Leu Leu His Ala Ile Arg Leu Leu Ala Asp Arg Gly

135 140 145gcc acc gac atc acc gcc atc tgc atg gtt tct gcg cag cca ggt gtg 595Ala Thr AspIle Thr Ala Ile Cys Met Val Ser Ala Gln Pro Gly Val150 155 160 165gac gca ttg gcg gaa tct 613Asp Ala Leu Ala Glu Ser

170<210>1106<211>171<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1106Met Asp Ile Thr Ile Val Asn His Pro Leu Val Ala Ser Arg Leu Thr 151015 Leu Leu Arg Asp Glu Arg Ser Asp Asn Ala Ala Phe Arg Ala Ala Ala

20 25 30Asn Asp Leu Gly Ala Met Leu Ile Tyr Glu Ala Ser Arg Asp Leu Glu

35 40 45Val Glu His Phe Asp Thr Lys Thr Pro Val Ala Met Ala Glu Gly Thr

50 55 60Arg Leu Lys Gln Pro Pro Ile Ile Val Pro Ile Ile Arg Ala Gly Leu 65 70 75 80Gly Met Ile Asp Pro Ala Leu Ser Met Ile Pro Asp Ala Gln Val Gly

85 90 95Phe Ile Gly Leu Ala Arg Asp Glu Glu Thr His Glu Pro Val Pro Tyr

100 105 110Leu Glu Ala Leu Pro Gln Asp Leu Ser Asn Gln Pro Val Phe Leu Val

115 120 125Asp Pro Met Leu Ala Thr Gly Gly Ser Leu Leu His Ala Ile Arg Leu

130 135 140Leu Ala Asp Arg Gly Ala Thr Asp Ile Thr Ala Ile Cys Met Val Ser145 150 155 160Ala Gln Pro Gly Val Asp Ala Leu Ala Glu Ser

165170<210>1107<211>613<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (613)<223>FRXA02857<400>1107atactttgtt ggactggaaa agtggccgtt tggttccctc caagcccaaa ttcgcccgcg 60cggtcttctt ctgggcggca atgatttaac atgtgaagct atg gac atc acc atc 115

Met Asp Ile Thr Ile

1 5gtc aac cac cca ctc gtt gct agc cgc cta acc ctg ttg cgc gac gag 163Val Asn His Pro Leu Val Ala Ser Arg Leu Thr Leu Leu Arg Asp Glu

10 15 20cgc agc gac aac gca gct ttc cgt gca gca gcc aac gac ctc ggc gcc 211Arg Ser Asp Asn Ala Ala Phe Arg Ala Ala Ala Asn Asp Leu Gly Ala

25 30 35atg ctg atc tac gaa gca tcc cga gat ctg gaa gtc gaa cac ttc gac 259Met Leu Ile Tyr Glu Ala Ser Arg Asp Leu Glu Val Glu His Phe Asp

40 45 50acc aaa acc ccc gtt gcc atg gct gaa ggt act cgc ctg aag cag cca 307Thr Lys Thr Pro Val Ala Met Ala Glu Gly Thr Arg Leu Lys Gln Pro

55 60 65ccc atc atc gtt ccc atc atc cgt gca ggt ctc ggc atg atc gac cca 355Pro Ile Ile Val Pro Ile Ile Arg Ala Gly Leu Gly Met Ile Asp Pro 70 75 80 85gcg ctg tcg atg att ccg gat gca cag gtc ggc ttc att ggc ctt gcc 403Ala Leu Ser Met Ile Pro Asp Ala Gln Val Gly Phe Ile Gly Leu Ala

90 95 100cgc gat gag gaa acc cat gag cca gtc cca tac ctt gag gcg ctg cca 451Arg Asp Glu Glu Thr His Glu Pro Val Pro Tyr Leu Glu Ala Leu Pro

105 110 115cag gat cta agc aac cag cct gta ttc ctt gtc gat ccc atg ctg gcc 499Gln Asp Leu Ser Asn Gln Pro Val Phe Leu Val Asp Pro Met Leu Ala

120 125 130acc ggc ggt tcc ctc ctg cac gcg atc cgc ctt ctt gct gat cgt ggc 547Thr Gly Gly Ser Leu Leu His Ala Ile Arg Leu Leu Ala Asp Arg Gly

135 140 145gcc acc gac atc acc gcc atc tgc atg gtt tct gcg cag cca ggt gtg 595Ala Thr Asp Ile Thr Ala Ile Cys Met Val Ser Ala Gln Pro Gly Val150 155 160 165gac gca ttg gcg gaa tct 613Asp Ala Leu Ala Glu Ser

170<210>1108<211>171<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1108Met Asp Ile Thr Ile Val Asn His Pro Leu Val Ala Ser Arg Leu Thr 151015 Leu Leu Arg Asp Glu Arg Ser Asp Asn Ala Ala Phe Arg Ala Ala Ala

20 25 30Asn Asp Leu Gly Ala Met Leu Ile Tyr Glu Ala Ser Arg Asp Leu Glu

35 40 45Val Glu His Phe Asp Thr Lys Thr Pro Val Ala Met Ala Glu Gly Thr

50 55 60Arg Leu Lys Gln Pro Pro Ile Ile Val Pro Ile Ile Arg Ala Gly Leu 65 70 75 80Gly Met Ile Asp Pro Ala Leu Ser Met Ile Pro Asp Ala Gln Val Gly

85 90 95Phe Ile Gly Leu Ala Arg Asp Glu Glu Thr His Glu Pro Val Pro Tyr

100 105 110Leu Glu Ala Leu Pro Gln Asp Leu Ser Asn Gln Pro Val Phe Leu Val

115 120 125Asp Pro Met Leu Ala Thr Gly Gly Ser Leu Leu His Ala Ile Arg Leu

130 135 140Leu Ala Asp Arg Gly Ala Thr Asp Ile Thr Ala Ile Cys Met ValSer145 150 155 160Ala Gln Pro Gly Val Asp Ala Leu Ala Glu Ser

165170<210>1109<211>424<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (424)<223>RXN00450<400>1109tttgcgatga catggatttg gatccttccg aacaattgct gcgcatcgcg gaagaactcg 60gttttgataa tgatctggct cgggtggtgg gattcgacta gtg ggc gtt tta cct 115

Val Gly Val Leu Pro

1 5gtg cag gcg cgc atc aaa gac gat gag cgc cgc atg cgc cat gct ttg 163Val Gln Ala Arg Ile Lys Asp Asp Glu Arg Arg Met Arg His Ala Leu

10 15 20gat att gct cgc caa acc cct gag ggg gac gtt ccc gtt ggc gcc gtc 211Asp Ile Ala Arg Gln Thr Pro Glu Gly Asp Val Pro Val Gly Ala Val

25 30 35att tac gcg ccg acc ggg gag atc ctg gcg acc gca acg aac cgt cga 259Ile Tyr Ala Pro Thr Gly Glu Ile Leu Ala Thr Ala Thr Asn Arg Arg

40 45 50gaa gca gac cgc gat ccc acg gcc cac gcc gaa att att gct tta cga 307Glu Ala Asp Arg Asp Pro Thr Ala His Ala Glu Ile Ile Ala Leu Arg

55 60 65cga gcc gcc cgc cgt ttt tcc gac ggc tgg cgg ctg agt gac tgc acc 355Arg Ala Ala Arg Arg Phe Ser Asp Gly Trp Arg Leu Ser Asp Cys Thr 70 75 80 85gcg gtg gtc acc ttg gag ccc tgc agt atg tgc gcc ggc gcc ttg gtg 403Ala Val Val Thr Leu Glu Pro Cys Ser Met Cys Ala Gly Ala Leu Val

90 95 100ggt gct cga atc gga cgc atc424Gly Ala Arg Ile Gly Arg Ile

105<210>1110<211>108<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1110Val Gly Val Leu Pro Val Gln Ala Arg Ile Lys Asp Asp Glu Arg Arg 151015 Met Arg His Ala Leu Asp Ile Ala Arg Gln Thr Pro Glu Gly Asp Val

20 25 30Pro Val Gly Ala Val Ile Tyr Ala Pro Thr Gly Glu Ile Leu Ala Thr

35 40 45Ala Thr Asn Arg Arg Glu Ala Asp Arg Asp Pro Thr Ala His Ala Glu

50 55 60Ile Ile Ala Leu Arg Arg Ala Ala Arg Arg Phe Ser Asp Gly Trp Arg 65 70 75 80Leu Ser Asp Cys Thr Ala Val Val Thr Leu Glu Pro Cys Ser Met Cys

85 90 95Ala Gly Ala Leu Val Gly Ala Arg Ile Gly Arg Ile

100105<210>1111<211>418<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (418)<223>FRXA00450<400>1111tttgcgatga catggatttg gatccttccg aacaattgct gcgcatcgcg gaagaactcg 60gttttgataa tgatctggct cgggtggtgg gattcgacta gtg ggc gtt tta cct 115

Val Gly Val Leu Pro

1 5gtg cag gcg cgc atc aaa gac gat gag cgc cgc atg cgc cat gct ttg 163Val Gln Ala Arg Ile Lys Asp Asp Glu Arg Arg Met Arg His Ala Leu

10 15 20gat att gct cgc caa acc cct gag ggg gac gtt ccc gtt ggc gcc gtc 211Asp Ile Ala Arg Gln Thr Pro Glu Gly Asp Val Pro Val Gly Ala Val

25 30 35att tac gcg ccg acc ggg gag atc ctg gcg acc gca acg aac cgt cga 259Ile Tyr Ala Pro Thr Gly Glu Ile Leu Ala Thr Ala Thr Asn Arg Arg

40 45 50gaa gca gac cgc gat ccc acg gcc cac gcc gaa att att gct tta cga 307Glu Ala Asp Arg Asp Pro Thr Ala His Ala Glu Ile Ile Ala Leu Arg

55 60 65cga gcc gcc cgc cgt ttt tcc gac ggc tgg cgg ctg agt gac tgc acc 355Arg Ala Ala Arg Arg Phe Ser Asp Gly Trp Arg Leu Ser Asp Cys Thr 70 75 80 85gcg gtg gtc acc ttg gag ccc tgc agt atg tgc gcc ggc gcc ttg gtg 403Ala Val Val Thr Leu Glu Pro Cys Ser Met Cys Ala Gly Ala Leu Val

90 95 100ggt gct cga atc gga 418Gly Ala Arg Ile Gly

105<210>1112<211>106<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1112Val Gly Val Leu Pro Val Gln Ala Arg Ile Lys Asp Asp Glu Arg Arg 151015 Met Arg His Ala Leu Asp Ile Ala Arg Gln Thr Pro Glu Gly Asp Val

20 25 30Pro Val Gly Ala Val Ile Tyr Ala Pro Thr Gly Glu Ile Leu Ala Thr

35 40 45Ala Thr Asn Arg Arg Glu Ala Asp Arg Asp Pro Thr Ala His Ala Glu

50 55 60Ile Ile Ala Leu Arg Arg Ala Ala Arg Arg Phe Ser Asp Gly Trp Arg 65 70 75 80Leu Ser Asp Cys Thr Ala Val Val Thr Leu Glu Pro Cys Ser Met Cys

85 90 95Ala Gly Ala Leu Val Gly Ala Arg Ile Gly

100105<210>1113<211>615<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (592)<223>RXA00465<400>111 1113tccccaacgc gcaccgaact tagccggatc gcagacttca cctggatgtc caccgcagcc 60caagcgctac cagcgttgat gcgaggtttg agcgcctaac atg act gaa gat gac 115

Met Thr Glu Asp Asp

1 5tta gat ctg ctg cac cgc aca gta gaa cta gcc acc cag gca ctc aag 163Leu Asp Leu Leu His Arg Thr Val Glu Leu Ala Thr Gln Ala Leu Lys

10 15 20cag gga aac agt cct tat gga tcc ctg ctg gtt gat ccc ttc ggc gcg 211Gln Gly Asn Ser Pro Tyr Gly Ser Leu Leu Val Asp Pro Phe Gly Ala

25 30 35gtc gtt ttt gaa gac cac aac cga gat gcc gat ggg gat ctg acc aag 259Val Val Phe Glu Asp His Asn Arg Asp Ala Asp Gly Asp Leu Thr Lys

40 45 50cac ccg gaa ttc gcc atc gcc aaa tat gcg atc gaa aat tac agt gca 307His Pro Glu Phe Ala Ile Ala Lys Tyr Ala Ile Glu Asn Tyr Ser Ala

55 60 65tca gaa cgt gct gcg tgc act gtt tat acc tcg acg gaa cat tgc gcg 355Ser Glu Arg Ala Ala Cys Thr Val Tyr Thr Ser Thr Glu His Cys Ala 70 75 80 85atg tgc gcc ggt gcc cat gcg tgg gct gga ctg ggc aaa att tac tgc 403Met Cys Ala Gly Ala His Ala Trp Ala Gly Leu Gly Lys Ile Tyr Cys

90 95 100gcc acc aca ggt ggg caa aca gcc gct tgg tac gca aag tgg ggt gca 451Ala Thr Thr Gly Gly Gln Thr Ala Ala Trp Tyr Ala Lys Trp Gly Ala

105 110 115gaa tct ggg cct ttg aac ccg att tca gcg gac aaa att agc ccg aac 499Glu Ser Gly Pro Leu Asn Pro Ile Ser Ala Asp Lys Ile Ser Pro Asn

120 125 130ata tcc atc gaa gga cct gct tcc aga ttt gag gaa gtc ctg tat gaa 547Ile Ser Ile Glu Gly Pro Ala Ser Arg Phe Glu Glu Val Leu Tyr Glu

135140145 ctg cat cga tgg ttt tat tta ggg cag tct ccg aat aag gct ctt 592Leu His Arg Trp Phe Tyr Leu Gly Gln Ser Pro Asn Lys Ala Leu 150155160 tagcgctggg catgtgactt taa 615<210>1114<211>164<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1114Met Thr Glu Asp Asp Leu Asp Leu Leu His Arg Thr Val Glu Leu Ala 151015 Thr Gln Ala Leu Lys Gln Gly Asn Ser Pro Tyr Gly Ser Leu Leu Val

20 25 30Asp Pro Phe Gly Ala Val Val Phe Glu Asp His Asn Arg Asp Ala Asp

35 40 45Gly Asp Leu Thr Lys His Pro Glu Phe Ala Ile Ala Lys Tyr Ala Ile

50 55 60Glu Asn Tyr Ser Ala Ser Glu Arg Ala Ala Cys Thr Val Tyr Thr Ser 65 70 75 80Thr Glu His Cys Ala Met Cys Ala Gly Ala His Ala Trp Ala Gly Leu

85 90 95Gly Lys Ile Tyr Cys Ala Thr Thr Gly Gly Gln Thr Ala Ala Trp Tyr

100 105 110Ala Lys Trp Gly Ala Glu Ser Gly Pro Leu Asn Pro Ile Ser Ala Asp

115 120 125Lys Ile Ser Pro Asn Ile Ser Ile Glu Gly Pro Ala Ser Arg Phe Glu

130135140 Glu Val Leu Tyr Glu Leu His Arg Trp Phe Tyr Leu Gly Gln Ser Pro 145150155160 Asn Lys Ala Leu<210>1115<211>1083<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1060)<223>RXA00717<400>1115aagcatcagt taaagccccg actattaaaa tctcctaaaa taggctagaa ttcacgggat 60tcaatttcat acgttttctc tcaagattaa ggacacttac gtg acc cca ccc gct 115

Val Thr Pro Pro Ala

1 5cgc cga gat ggc aca ccg gac aag aag cag agc aat cgc tct ggc gga 163Arg Arg Asp Gly Thr Pro Asp Lys Lys Gln Ser Asn Arg Ser Gly Gly

10 15 20tac cgg tct tca gtt cgt ggc tac aag cca gga tca tcc cgc cca aac 211Tyr Arg Ser Ser Val Arg Gly Tyr Lys Pro Gly Ser Ser Arg Pro Asn

25 30 35aca cgc cag cag cct cag aag aag gat gag att ctt ctc tcc aac gct 259Thr Arg Gln Gln Pro Gln Lys Lys Asp Glu Ile Leu Leu Ser Asn Ala

40 45 50aag cct gcc aag aag caa aac gta aaa tcc gac gac gat tgg tcg atg 307Lys Pro Ala Lys Lys Gln Asn Val Lys Ser Asp Asp Asp Trp Ser Met

55 60 65ggt ttc tta aac cgc aat gac tct gac gga gtt cgc ctg cag aag gtg 355Gly Phe Leu Asn Arg Asn Asp Ser Asp Gly Val Arg Leu Gln Lys Val 70 75 80 85ctt gcc caa gca ggt gtg gca tca cgt cga cac gca gaa atc ctg att 403Leu Ala Gln Ala Gly Val Ala Ser Arg Arg His Ala Glu Ile Leu Ile

90 95 100gat cag ggc cgt gtg gag gtc aac gat cgt atc gtg acc acc cag ggc 451Asp Gln Gly Arg Val Glu Val Asn Asp Arg Ile Val Thr Thr Gln Gly

105 110 115gtg cgc gtg gat cca aac aac gat gtc atc cgt gtt gac ggc gtc cgc 499Val Arg Val Asp Pro Asn Asn Asp Val Ile Arg Val Asp Gly Val Arg

120 125 130atc cac atc aac gag gac ctc gag tac ttc gtg ctc aac aag cct cgt 547Ile His Ile Asn Glu Asp Leu Glu Tyr Phe Val Leu Asn Lys Pro Arg

135 140 145ggc atg cac tcc acc atg agc gat gaa ctt ggt cgc cca tgc gtg ggt 595Gly Met His Ser Thr Met Ser Asp Glu Leu Gly Arg Pro Cys Val Gly150 155 160 165gat ctg gtc agt gag aag act gca tct gga cag cgt ctg ttc cac gtc 643Asp Leu Val Ser Glu Lys Thr Ala Ser Gly Gln Arg Leu Phe His Val

170 175 180ggt cgc ctc gac gcg gac acc gaa ggt ttg ctg ctg ctc acc aac gat 691Gly Arg Leu Asp Ala Asp Thr Glu Gly Leu Leu Leu Leu Thr Asn Asp

185 190 195ggt gag ttg gct aac cgc ctc atg cac cct aag tac gaa gtg tcc aag 739Gly Glu Leu Ala Asn Arg Leu Met His Pro Lys Tyr Glu Val Ser Lys

200 205 210act tac ctt gct acc gtt cgc ggt gaa gca acc aat aag cta gtc agc 787Thr Tyr Leu Ala Thr Val Arg Gly Glu Ala Thr Asn Lys Leu Val Ser

215 220 225gct ctt cgt gat ggc gtg gag ttg gaa gat ggc cct gcc aag gct gac 835Ala Leu Arg Asp Gly Val Glu Leu Glu Asp Gly Pro Ala Lys Ala Asp230 235 240 245ttt gcg cag att atc gac gta ttc cag ggc aag tcc ttg ttg cgc atc 883Phe Ala Gln Ile Ile Asp Val Phe Gln Gly Lys Ser Leu Leu Arg Ile

250 255 260gaa atc cac gaaggc cgc aag cac att gtg cga cgc ctc ttc gat gag 931Glu Ile His Glu Gly Arg Lys His Ile Val Arg Arg Leu Phe Asp Glu

265 270 275ctc ggt ttc cca gtc gag cgc ctc gtg cgc acc aag ctg cac acc gtt 979Leu Gly Phe Pro Val Glu Arg Leu Val Arg Thr Lys Leu His Thr Val

280 285 290cag ctt ggt gat cag aag cca ggt tcc ctt cgt gca ctg aac tcc tct 1027Gln Leu Gly Asp Gln Lys Pro Gly Ser Leu Arg Ala Leu Asn Ser Ser

295300305 gag ctg acc agc tta tac aag gtg gtc caa ctg tgacggaaat ttccaacatg 1080Glu Leu Thr Ser Leu Tyr Lys Val Val Gln Leu 310315320 cct 1083<210>1116<211>320<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1116Val Thr Pro Pro Ala Arg Arg Asp Gly Thr Pro Asp Lys Lys Gln Ser 151015 Asn Arg Ser Gly Gly Tyr Arg Ser Ser Val Arg Gly Tyr Lys Pro Gly

20 25 30Ser Ser Arg Pro Asn Thr Arg Gln Gln Pro Gln Lys Lys Asp Glu Ile

35 40 45Leu Leu Ser Asn Ala Lys Pro Ala Lys Lys Gln Asn Val Lys Ser Asp

50 55 60Asp Asp Trp Ser Met Gly Phe Leu Asn Arg Asn Asp Ser Asp Gly Val 65 70 75 80Arg Leu Gln Lys Val Leu Ala Gln Ala Gly Val Ala Ser Arg Arg His

85 90 95Ala Glu Ile Leu Ile Asp Gln Gly Arg Val Glu Val Asn Asp Arg Ile

100 105 110Val Thr Thr Gln Gly Val Arg Val Asp Pro Asn Asn Asp Val Ile Arg

115 120 125Val Asp Gly Val Arg Ile His Ile Asn Glu Asp Leu Glu Tyr Phe Val

130 135 140Leu Asn Lys Pro Arg Gly Met His Ser Thr Met Ser Asp Glu Leu Gly145 150 155 160Arg Pro Cys Val Gly Asp Leu Val Ser Glu Lys Thr Ala Ser Gly Gln

165 170 175Arg Leu Phe His Val Gly Arg Leu Asp Ala Asp Thr Glu Gly Leu Leu

180 185 190Leu Leu Thr Asn Asp Gly Glu Leu Ala Asn Arg Leu Met His Pro Lys

195 200 205Tyr Glu Val Ser Lys Thr Tyr Leu Ala Thr Val Arg Gly Glu Ala Thr

210 215 220Asn Lys Leu Val Ser Ala Leu Arg Asp Gly Val Glu Leu Glu Asp Gly225 230 235 240Pro Ala Lys Ala Asp Phe Ala Gln Ile Ile Asp Val Phe Gln Gly Lys

245 250 255Ser Leu Leu Arg Ile Glu Ile His Glu Gly Arg Lys His Ile Val Arg

260 265 270Arg Leu Phe Asp Glu Leu Gly Phe Pro Val Glu Arg Leu Val Arg Thr

275 280 285Lys Leu His Thr Val Gln Leu Gly Asp Gln Lys Pro Gly Ser Leu Arg

290295300 Ala Leu Asn Ser Ser Glu Leu Thr Ser Leu Tyr Lys Val Val Gln Leu 305310315320<210>1117<211>978<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (955)<223>RXA01894<400>1117agaatttttt cgaaaatgct ggcaccatca acagtgacat tgttagaaac ttcaaggaga 60acccatgaat gaaccggagc aacatcaccg gtccatgagg atg ccc aaa ccc aaa 115

Met Pro Lys Pro Lys

1 5aat aat gcg ggt cga gat ctc aaa gct gcc att gct gtg ggg atc gga 163Asn Asn Ala Gly Arg Asp Leu Lys Ala Ala Ile Ala Val Gly Ile Gly

10 15 20ctg ggg gtc ctg gtt ctt ttg ggg att gtc cta agc cca tgg ggt tgg 211Leu Gly Val Leu Val Leu Leu Gly Ile Val Leu Ser Pro Trp Gly Trp

25 30 35tac atc ctc gtt gca ggt ttt atg gct gca gca aca tgg gaa gtt ggt 259Tyr Ile Leu Val Ala Gly Phe Met Ala Ala Ala Thr Trp Glu Val Gly

40 45 50agc aga ctt aaa gaa ggc ggc tat cat ttg cca ctg ccg att atg atc 307Ser Arg Leu Lys Glu Gly Gly Tyr His Leu Pro Leu Pro Ile Met Ile

55 60 65atc ggc ggt cag gca atc atc tgg ctg tca tgg cca ttt ggc acg atg 355Ile Gly Gly Gln Ala Ile Ile Trp Leu Ser Trp Pro Phe Gly Thr Met 70 75 80 85ggc att ttg gcg tct ttt gtg gcc act gtg ttg gtg ctg atg tat ttc 403Gly Ile Leu Ala Ser Phe Val Ala Thr Val Leu Val Leu Met Tyr Phe

90 95 100cga att ttc tac aat ggc acg gaa aaa gaa gcc cgc aac tat ttg agg 451Arg Ile Phe Tyr Asn Gly Thr Glu Lys Glu Ala Arg Asn Tyr Leu Arg

105 110 115gac acc tct gtg ggc atc ttc gtg ctc acc tgg att cca ttg ttc gga 499Asp Thr Ser Val Gly Ile Phe Val Leu Thr Trp Ile Pro Leu Phe Gly

120 125 130agc ttc gct gcg atg ctg tcg ctg atg caa aac aat tcc atc ccg ggt 547Ser Phe Ala Ala Met Leu Ser Leu Met Gln Asn Asn Ser Ile Pro Gly

135 140145aca tat ttc att ttg acg ttc atg ctg tgt gtg atc gca tcg gat gtg 595Thr Tyr Phe Ile Leu Thr Phe Met Leu Cys Val Ile Ala Ser Asp Val150 155 160 165ggc ggg tat atc gcg ggt gtg ttc ttt gga tcg cac cca atg gcg ccg 643Gly Gly Tyr Ile Ala Gly Val Phe Phe Gly Ser His Pro Met Ala Pro

170 175 180ttg gtg agt ccg aag aag tct tgg gaa ggc ttt gcc ggc tcc att gtc 691Leu Val Ser Pro Lys Lys Ser Trp Glu Gly Phe Ala Gly Ser Ile Val

185 190 195tta gga tcg gtc act ggt gca ctc agt gtt cac ttc ctg ctc gat cac 739Leu Gly Ser Val Thr Gly Ala Leu Ser Val His Phe Leu Leu Asp His

200 205 210cac tgg tgg atg ggt gtg atc ttg ggt tgt gcc cta gtt gtg tgc gcc 787His Trp Trp Met Gly Val Ile Leu Gly Cys Ala Leu Val Val Cys Ala

215 220 225acg ttg ggt gac ttg gtt gag tcg cag ttc aaa cgc gat ttg ggc atc 835Thr Leu Gly Asp Leu Val Glu Ser Gln Phe Lys Arg Asp Leu Gly Ile230 235 240 245aag gat atg tcg aac ctt ctt cca ggc cac ggc gga ttg atg gac cgt 883Lys Asp Met Ser Asn Leu Leu Pro Gly His Gly Gly Leu Met Asp Arg

250 255 260ttg gat ggc atg ctc ccg gcc gcg atg gtg acg tgg ttg atc ctg agt 931Leu Asp Gly Met Leu Pro Ala Ala Met Val Thr Trp Leu Ile Leu Ser

265 270 275gtg atc agc agc tcg tat ccg tcg taaagcttgg gccagcttta agt 978Val Ile Ser Ser Ser Tyr Pro Ser

280285<210>1118<211>285<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1118Met Pro Lys Pro Lys Asn Asn Ala Gly Arg Asp Leu Lys Ala Ala Ile 151015 Ala Val Gly Ile Gly Leu Gly Val Leu Val Leu Leu Gly Ile Val Leu

20 25 30Ser Pro Trp Gly Trp Tyr Ile Leu Val Ala Gly Phe Met Ala Ala Ala

35 40 45Thr Trp Glu Val Gly Ser Arg Leu Lys Glu Gly Gly Tyr His Leu Pro

50 55 60Leu Pro Ile Met Ile Ile Gly Gly Gln Ala Ile Ile Trp Leu Ser Trp 65 70 75 80Pro Phe Gly Thr Met Gly Ile Leu Ala Ser Phe Val Ala Thr Val Leu

85 90 95Val Leu Met Tyr Phe Arg Ile Phe Tyr Asn Gly Thr Glu Lys Glu Ala

100 105 110Arg Asn Tyr Leu Arg Asp Thr Ser Val Gly Ile Phe Val Leu Thr Trp

115 120 125Ile Pro Leu Phe Gly Ser Phe Ala Ala Met Leu Ser Leu Met Gln Asn

130 135 140Asn Ser Ile Pro Gly Thr Tyr Phe Ile Leu Thr Phe Met Leu Cys Val145 150 155 160Ile Ala Ser Asp Val Gly Gly Tyr Ile Ala Gly Val Phe Phe Gly Ser

165 170 175His Pro Met Ala Pro Leu Val Ser Pro Lys Lys Ser Trp Glu Gly Phe

180 185 190Ala Gly Ser Ile Val Leu Gly Ser Val Thr Gly Ala Leu Ser Val His

195 200 205Phe Leu Leu Asp His His Trp Trp Met Gly Val Ile Leu Gly Cys Ala

210 215 220Leu Val Val Cys Ala Thr Leu Gly Asp Leu Val Glu Ser Gln Phe Lys225 230 235 240Arg Asp Leu Gly Ile Lys Asp Met Ser Asn Leu Leu Pro Gly His Gly

245 250 255Gly Leu Met Asp Arg Leu Asp Gly Met Leu Pro Ala Ala Met Val Thr

260 265 270Trp Leu Ile Leu Ser Val Ile Ser Ser Ser Tyr Pro Ser

275280285<210>1119<211>879<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (856)<223>RXA02536<400>1119aagaagtgat cacgcgaacc tgtgtataac ttgcctcaaa gcgcctaggc tgtggattat 60gcgtattgcc ttgcttcaga tctcgacgaa ttccgataag atg gac aac ttc gcc 115

Met Asp Asn Phe Ala

1 5ctg ctg cgt gat gct gct gaa aaa gct gcg gaa cag ggg gct cgg gtg 163Leu Leu Arg Asp Ala Ala Glu Lys Ala Ala Glu Gln Gly Ala Arg Val

10 15 20ttg gtg ttt ccg gag gcg act tcg caa agc ttt ggt acg gga agg ctt 211Leu Val Phe Pro Glu Ala Thr Ser Gln Ser Phe Gly Thr Gly Arg Leu

25 30 35gat act cag gcg gag gag ctc gat ggc gaa ttc tcc acc gcg gta cga 259Asp Thr Gln Ala Glu Glu Leu Asp Gly Glu Phe Ser Thr Ala Val Arg

40 45 50aaa tta gcc gat gag ctg gac gtt gtc atc gtt gcg ggc atg ttc acc 307Lys Leu Ala Asp Glu Leu Asp Val Val Ile Val Ala Gly Met Phe Thr

55 60 65cct gct gac acc gtg cag cgc ggt gaa aaa acg atc tcg cgc gtc aac 355Pro Ala Asp Thr Val Gln Arg Gly Glu Lys Thr Ile Ser Arg Val Asn 70 7580 85aac acc gtg ctg att agt ggc gct gga ttg cat cag gga tac aac aaa 403Asn Thr Val Leu Ile Ser Gly Ala Gly Leu His Gln Gly Tyr Asn Lys

90 95 100att cac aca tat gac gcg ttc ggt tat agg gaa tcc gac act gtg aaa 451Ile His Thr Tyr Asp Ala Phe Gly Tyr Arg Glu Ser Asp Thr Val Lys

105 110 115ccg ggc gat gag ctg gtt gta ttc gag gtc gac gat att aaa ttt ggt 499Pro Gly Asp Glu Leu Val Val Phe Glu Val Asp Asp Ile Lys Phe Gly

120 125 130gtg gcg aca tgc tac gat att cga ttc cca gaa cag ttc aaa gac ctc 547Val Ala Thr Cys Tyr Asp Ile Arg Phe Pro Glu Gln Phe Lys Asp Leu

135 140 145gcc cgc aac ggt gca cag ata att gtg gtt ccc acg tcg tgg caa gac 595Ala Arg Asn Gly Ala Gln Ile Ile Val Val Pro Thr Ser Trp Gln Asp150 155 160 165ggt cct gga aaa tta gaa caa tgg gaa gtc ctc cct cgc gcg cgt gca 643Gly Pro Gly Lys Leu Glu Gln Trp Glu Val Leu Pro Arg Ala Arg Ala

170 175 180ctg gat tcc acc tgc tgg atc gta gcg tgt ggg caa gcg cga ctt cca 691Leu Asp Ser Thr Cys Trp Ile Val Ala Cys Gly Gln Ala Arg Leu Pro

185 190 195gaa gaa tta cgc gat gaa cga aaa ggc cct acg ggg att ggt cat tcc 739Glu Glu Leu Arg Asp Glu Arg Lys Gly Pro Thr Gly Ile Gly His Ser

200 205 210atg gtg aca aac cca cac ggt gaa gta att gct agc gcg ggt tat gag 787Met Val Thr Asn Pro His Gly Glu Val Ile Ala Ser Ala Gly Tyr Glu

215 220 225cca gaa atg ttg atc gcg gat att gat gtc agc ggt ttg gcc aaa att 835Pro Glu Met Leu Ile Ala Asp Ile Asp Val Ser Gly Leu Ala Lys Ile230 235 240 245cgg gag gca ttg cct gtt ctt taaccactgt ctaaggaatc act 879Arg Glu Ala Leu Pro Val Leu

250<210>1120<211>252<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1120Met Asp Asn Phe Ala Leu Leu Arg Asp Ala Ala Glu Lys Ala Ala Glu 151015 Gln Gly Ala Arg Val Leu Val Phe Pro Glu Ala Thr Ser Gln Ser Phe

20 25 30Gly Thr Gly Arg Leu Asp Thr Gln Ala Glu Glu Leu Asp Gly Glu Phe

35 40 45Ser Thr Ala Val Arg Lys Leu Ala Asp Glu Leu Asp Val Val Ile Val

50 55 60Ala Gly Met Phe Thr Pro Ala Asp Thr Val Gln Arg Gly Glu Lys Thr 65 70 75 80Ile Ser Arg Val Asn Asn Thr Val Leu Ile Ser Gly Ala Gly Leu His

85 90 95Gln Gly Tyr Asn Lys Ile His Thr Tyr Asp Ala Phe Gly Tyr Arg Glu

100 105 110Ser Asp Thr Val Lys Pro Gly Asp Glu Leu Val Val Phe Glu Val Asp

115 120 125Asp Ile Lys Phe Gly Val Ala Thr Cys Tyr Asp Ile Arg Phe Pro Glu

130 135 140Gln Phe Lys Asp Leu Ala Arg Asn Gly Ala Gln Ile Ile Val Val Pro145 150 155 160Thr Ser Trp Gln Asp Gly Pro Gly Lys Leu Glu Gln Trp Glu Val Leu

165 170 175Pro Arg Ala Arg Ala Leu Asp Ser Thr Cys Trp Ile Val Ala CysGly

180 185 190Gln Ala Arg Leu Pro Glu Glu Leu Arg Asp Glu Arg Lys Gly Pro Thr

195 200 205Gly Ile Gly His Ser Met Val Thr Asn Pro His Gly Glu Val Ile Ala

210 215 220Ser Ala Gly Tyr Glu Pro Glu Met Leu Ile Ala Asp Ile Asp Val Ser225 230 235 240Gly Leu Ala Lys Ile Arg Glu Ala Leu Pro Val Leu

245250<210>1121<211>1528<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1528)<223>RXN01209<400>1121cagattgcag cacagaaggc atcggcgcca ggcagctttg cggtggcgtt tattgatgcg 60ctttatgacg tggatgccca ggctgtggcc tcgttggttg atg tgc gag agg cct 115

Met Cys Glu Arg Pro

1 5gaa aag tac gtg act gat ttt tct ttg tat ctg gtc acc gat ccc gtt 163Glu Lys Tyr Val Thr Asp Phe Ser Leu Tyr Leu Val Thr Asp Pro Val

10 15 20ttg ggt ggc ggg cca aaa aaa gta gct gga att gtt gac agc gca att 211Leu Gly Gly Gly Pro Lys Lys Val Ala Gly Ile Val Asp Ser Ala Ile

25 30 35tcc ggc gga gtt tct gtg gtg cag ctg cgc gat aag aac tca ggc gtg 259Ser Gly Gly Val Ser Val Val Gln Leu Arg Asp Lys Asn Ser Gly Val

40 45 50gaa gat gtt cgt gcg gca gca aag gag ctg aaa gaa ctc tgc gat gct 307Glu Asp Val Arg Ala Ala Ala Lys Glu Leu Lys Glu Leu Cys Asp Ala

55 60 65cgcggg gtg gcg ctt gtt gtc aac gat tac tta gat atc gcc gtt gag 355Arg Gly Val Ala Leu Val Val Asn Asp Tyr Leu Asp Ile Ala Val Glu 70 75 80 85ctg ggt ctt cac ctg cac att ggt caa ggc gat aca cct tat acg caa 403Leu Gly Leu His Leu His Ile Gly Gln Gly Asp Thr Pro Tyr Thr Gln

90 95 100gca cgg gag ctg ctt cca gct cat ctt gaa ttg ggt ttg agc att gaa 451Ala Arg Glu Leu Leu Pro Ala His Leu Glu Leu Gly Leu Ser Ile Glu

105 110 115aac ctg gat caa ttg cat gct gtg atc gcg cag tgc gcc gag act ggt 499Asn Leu Asp Gln Leu His Ala Val Ile Ala Gln Cys Ala Glu Thr Gly

120 125 130gtg gca ttg ccc gat gtg att ggc att ggt ccg gtg gcc tct act gcg 547Val Ala Leu Pro Asp Val Ile Gly Ile Gly Pro Val Ala Ser Thr Ala

135 140 145acc aaa cca gat gcg gca ccc gca ttg ggt gtg gag ggc atc gct gag 595Thr Lys Pro Asp Ala Ala Pro Ala Leu Gly Val Glu Gly Ile Ala Glu150 155 160 165atc gcc gct gta gct caa gac cac ggc atc gca tca gta gct att gga 643Ile Ala Ala Val Ala Gln Asp His Gly Ile Ala Ser Val Ala Ile Gly

170 175 180ggc gtt ggt cta cgc aac gcg gcc gaa ctc gct gct acg ccc atc gac 691Gly Val Gly Leu Arg Asn Ala Ala Glu Leu Ala Ala Thr Pro Ile Asp

185 190 195ggt ctg tgc gtg gtc tct gaa atc atg acc gcc gcc aat cca gca gct 739Gly Leu Cys Val Val Ser Glu Ile Met Thr Ala Ala Asn Pro Ala Ala

200 205 210gcg gca act cgc ctg cgg act gct ttt caa cct act ttc tcg cct gaa 787Ala Ala Thr Arg Leu Arg Thr AlaPhe Gln Pro Thr Phe Ser Pro Glu

215 220 225act caa act gaa ctc tct caa aca gaa ctc caa gga gcc ttc gtg aat 835Thr Gln Thr Glu Leu Ser Gln Thr Glu Leu Gln Gly Ala Phe Val Asn230 235 240 245tcg cct tct gcc cca cgt gtg ttg tct att gca ggc act gat ccc aca 883Ser Pro Ser Ala Pro Arg Val Leu Ser Ile Ala Gly Thr Asp Pro Thr

250 255 260ggt ggt gca ggt att cag gct gat ctg aag tcc att gca gca ggt ggc 931Gly Gly Ala Gly Ile Gln Ala Asp Leu Lys Ser Ile Ala Ala Gly Gly

265 270 275ggc tac ggc atg tgc gtt gtg acc tcg ctg gtc gcg caa aac acc cac 979Gly Tyr Gly Met Cys Val Val Thr Ser Leu Val Ala Gln Asn Thr His

280 285 290ggc gtc aac acg atc cac acc cca ccc ttg acc ttt ttg gaa gaa cag 1027Gly Val Asn Thr Ile His Thr Pro Pro Leu Thr Phe Leu Glu Glu Gln

295 300 305ctg gaa gcg gtc ttt tcc gat gtc acc gtc gat gcc atc aag ctc ggc 1075Leu Glu Ala Val Phe Ser Asp Val Thr Val Asp Ala Ile Lys Leu Gly310 315 320 325atg ttg ggc tct gcc gac acc gtc gat ctg gtg gct tca tgg ctt ggt 1123Met Leu Gly Ser Ala Asp Thr Val Asp Leu Val Ala Ser Trp Leu Gly

330 335 340tcc cac gag cac ggt ccc gtg gtg ctt gat ccc gtc atg atc gcc acc 1171Ser His Glu His Gly Pro Val Val Leu Asp Pro Val Met Ile Ala Thr

345 350 355agc ggt gat cgc cta ctg gat gcg agc gct gaa gaa tcg ctg cgc cgc 1219Ser Gly Asp Arg Leu Leu Asp Ala Ser Ala Glu Glu Ser Leu Arg Arg

360365 370ctg gcc gtg cac gtc gat gtg gtc acc ccg aat atc ccc gaa ctt gcc 1267Leu Ala Val His Val Asp Val Val Thr Pro Asn Ile Pro Glu Leu Ala

375 380 385gtg ttg tgc gac agt gct cct gcc atc acc atg gat gag gcc att gct 1315Val Leu Cys Asp Ser Ala Pro Ala Ile Thr Met Asp Glu Ala Ile Ala390 395 400 405cag gct cag gga ttt gcg cgg act cat gac acc atc gtc att gtc aag 1363Gln Ala Gln Gly Phe Ala Arg Thr His Asp Thr Ile Val Ile Val Lys

410 415 420ggt gga cat ctg act ggc gcg ctt gct gat aac gct gtc gtg cgc ccc 1411Gly Gly His Leu Thr Gly Ala Leu Ala Asp Asn Ala Val Val Arg Pro

425 430 435gac ggc tcg gtg ttc cag gtg gaa aac ctg cgt gtc aac acc acc aac 1459Asp Gly Ser Val Phe Gln Val Glu Asn Leu Arg Val Asn Thr Thr Asn

440 445 450tcc cat ggc aca ggc tgt tcg ctc tct gcg tca ctt gcc acc aag atc 1507Ser His Gly Thr Gly Cys Ser Leu Ser Ala Ser Leu Ala Thr Lys Ile

455460465 gcc gcc ggc gaa agc gtg gaa 1528Ala Ala Gly Glu Ser Val Glu 470475<210>1122<211>476<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1122Met Cys Glu Arg Pro Glu Lys Tyr Val Thr Asp Phe Ser Leu Tyr Leu 151015 Val Thr Asp Pro Val Leu Gly Gly Gly Pro Lys Lys Val Ala Gly Ile

20 25 30Val Asp Ser Ala Ile Ser Gly Gly Val Ser Val Val Gln Leu Arg Asp

35 40 45Lys Asn Ser Gly Val Glu Asp Val Arg Ala Ala Ala Lys Glu Leu Lys

50 55 60 Glu Leu Cys Asp Ala Arg Gly Val Ala Leu Val Val Asn Asp Tyr Leu 65 70 75 80Asp Ile Ala Val Glu Leu Gly Leu His Leu His Ile Gly Gln Gly Asp

85 90 95Thr Pro Tyr Thr Gln Ala Arg Glu Leu Leu Pro Ala His Leu Glu Leu

100 105 1l0Gly Leu Ser Ile Glu Asn Leu Asp Gln Leu His Ala Val Ile Ala Gln

115 120 125Cys Ala Glu Thr Gly Val Ala Leu Pro Asp Val Ile Gly Ile Gly Pro

130 135 140Val Ala Ser Thr Ala Thr Lys Pro Asp Ala Ala Pro Ala Leu Gly Val145 150 155 160Glu Gly Ile Ala Glu Ile Ala Ala Val Ala Gln Asp His Gly Ile Ala

165 170 175Ser Val Ala Ile Gly Gly Val Gly Leu Arg Asn Ala Ala Glu Leu Ala

180 185 190Ala Thr Pro Ile Asp Gly Leu Cys Val Val Ser Glu Ile Met Thr Ala

195 200 205Ala Asn Pro Ala Ala Ala Ala Thr Arg Leu Arg Thr Ala Phe Gln Pro

210 215 220Thr Phe Ser Pro Glu Thr Gln Thr Glu Leu Ser Gln Thr Glu Leu Gln225 230 235 240Gly Ala Phe Val Asn Ser Pro Ser Ala Pro Arg Val Leu Ser Ile Ala

245 250 255Gly Thr Asp Pro Thr Gly Gly Ala Gly Ile Gln Ala Asp Leu Lys Ser

260 265 270Ile Ala Ala Gly Gly Gly Tyr Gly Met Cys Val Val Thr Ser Leu Val

275 280 285Ala Gln Asn Thr His Gly Val Asn Thr Ile His Thr Pro Pro Leu Thr

290 295 300Phe Leu Glu Glu Gln Leu Glu Ala Val Phe Ser Asp Val Thr Val Asp305 310 315 320Ala Ile Lys Leu Gly Met Leu Gly Ser Ala Asp Thr Val Asp Leu Val

325 330 335Ala Ser Trp Leu Gly Ser His Glu His Gly Pro Val Val Leu Asp Pro

340 345 350Val Met Ile Ala Thr Ser Gly Asp Arg Leu Leu Asp Ala Ser Ala Glu

355 360 365Glu Ser Leu Arg Arg Leu Ala Val His Val Asp Val Val Thr Pro Asn

370 375 380Ile Pro Glu Leu Ala Val Leu Cys Asp Ser Ala Pro Ala Ile Thr Met385 390 395 400Asp Glu Ala Ile Ala Gln Ala Gln Gly Phe Ala Arg Thr His Asp Thr

405 410 415Ile Val Ile Val Lys Gly Gly His Leu Thr Gly Ala Leu Ala Asp Asn

420 425 430Ala Val Val Arg Pro Asp Gly Ser Val Phe Gln Val Glu Asn Leu Arg

435 440 445Val Asn Thr Thr Asn Ser His Gly Thr Gly Cys Ser Leu Ser Ala Ser

450455460 Leu Ala Thr Lys Ile Ala Ala Gly Glu Ser Val Glu 465470475<210>1123<211>1528<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1528)<223>FRXA01209<400>1123cagattgcag cacagaaggc atcggcgcca ggcagctttg cggtggcgtt tattgatgcg 60ctttatgacg tggatgccca ggctgtggcc tcgttggttg atg tgc gag agg cct 115

Met Cys Glu Arg Pro

1 5gaa aag tac gtg act gat ttt tct ttg tat ctg gtc acc gat ccc gtt 163Glu Lys Tyr Val Thr Asp Phe Ser Leu Tyr Leu Val Thr Asp Pro Val

10 15 20ttg ggt ggc ggg cca aaa aaa gta gct gga att gtt gac agc gca att 211Leu Gly Gly Gly Pro Lys Lys Val Ala Gly Ile Val Asp Ser Ala Ile

25 30 35tcc ggc gga gtt tct gtg gtg cag ctg cgc gat aag aac tca ggc gtg 259Ser Gly Gly Val Ser Val Val Gln Leu Arg Asp Lys Asn Ser Gly Val

40 45 50gaa gat gtt cgt gcg gca gca aag gag ctg aaa gaa ctc tgc gat gct 307Glu Asp Val Arg Ala Ala Ala Lys Glu Leu Lys Glu Leu Cys Asp Ala

55 60 65cgc ggg gtg gcg ctt gtt gtc aac gat tac tta gat atc gcc gtt gag 355Arg Gly Val Ala Leu Val Val Asn Asp Tyr Leu Asp Ile Ala Val Glu 70 75 80 85ctg ggt ctt cac ctg cac att ggt caa ggc gat aca cct tat acg caa 403Leu Gly Leu His Leu His Ile Gly Gln Gly Asp Thr Pro Tyr Thr Gln

90 95 100gca cgg gag ctg ctt cca gct cat ctt gaa ttg ggt ttg agc att gaa 451Ala Arg Glu Leu Leu Pro Ala His Leu Glu Leu Gly Leu Ser Ile Glu

105 110 115aac ctg gat caa ttg cat gct gtg atc gcg cag tgc gcc gag act ggt 499Asn Leu Asp Gln Leu His Ala Val Ile Ala Gln Cys Ala Glu Thr Gly

120 125 130gtg gca ttg ccc gat gtg att ggc att ggt ccg gtg gcc tct act gcg 547Val Ala Leu Pro Asp Val Ile Gly Ile Gly Pro Val Ala Ser Thr Ala

135 140 145acc aaa cca gat gcg gca ccc gca ttg ggt gtg gag ggc atc gct gag 595Thr Lys Pro Asp Ala Ala Pro Ala Leu Gly Val Glu Gly Ile Ala Glu150 155 160 165atc gcc gct gta gct caa gac cac ggc atc gca tca gta gct att gga 643Ile Ala Ala Val Ala Gln Asp His Gly Ile Ala Ser Val Ala Ile Gly

170 175 180ggc gtt ggt cta cgc aac gcg gcc gaa ctc gct gct acg ccc atc gac 691Gly Val Gly Leu Arg Asn Ala Ala Glu Leu Ala Ala Thr Pro Ile Asp

185 190 195ggt ctg tgc gtg gtc tct gaa atc atg acc gcc gcc aat cca gca gct 739Gly Leu Cys Val Val Ser Glu Ile Met Thr Ala Ala Asn Pro Ala Ala

200 205 210gcg gca act cgc ctg cgg act gct ttt caa cct act ttc tcg cct gaa 787Ala Ala Thr Arg Leu Arg Thr Ala Phe Gln Pro Thr Phe Ser Pro Glu

215 220 225act caa act gaa ctc tct caa aca gaa ctc caa gga gcc ttc gtg aat 835Thr Gln Thr Glu Leu Ser Gln Thr Glu Leu Gln Gly Ala Phe Val Asn230 235 240 245tcg cct tct gcc cca cgt gtg ttg tct att gca ggc act gat ccc aca 883Ser Pro Ser Ala Pro Arg Val Leu Ser Ile Ala Gly Thr Asp Pro Thr

250 255 260ggt ggt gca ggt att cag gct gat ctg aag tcc att gca gca ggt ggc 931Gly Gly Ala Gly Ile Gln Ala Asp Leu Lys Ser Ile Ala Ala Gly Gly

265 270 275ggc tac ggc atg tgc gtt gtg acc tcg ctg gtc gcg caa aac acc cac 979Gly Tyr Gly Met Cys Val Val Thr Ser Leu Val Ala Gln Asn Thr His

280 285 290ggc gtc aac acg atc cac acc cca ccc ttg acc ttt ttg gaa gaa cag 1027Gly Val Asn Thr Ile His Thr Pro Pro Leu Thr Phe Leu Glu Glu Gln

295 300 305ctg gaa gcg gtc ttt tcc gat gtc acc gtc gat gcc atc aag ctc ggc 1075Leu Glu Ala Val Phe Ser Asp Val Thr Val Asp Ala Ile Lys Leu Gly310 315 320 325atg ttg ggc tct gcc gac acc gtc gat ctg gtg gct tca tgg ctt ggt 1123Met Leu Gly Ser Ala Asp Thr Val Asp Leu Val Ala Ser Trp Leu Gly

330 335 340tcc cac gag cac ggt ccc gtg gtg ctt gat ccc gtc atg atc gcc acc 1171Ser His Glu His Gly Pro Val Val Leu Asp Pro Val Met Ile Ala Thr

345 350 355agc ggt gat cgc cta ctg gat gcg agc gct gaa gaa tcg ctg cgc cgc 1219Ser Gly Asp Arg Leu Leu Asp Ala Ser Ala Glu Glu Ser Leu Arg Arg

360 365 370ctg gcc gtg cac gtc gat gtg gtc acc ccg aat atc ccc gaa ctt gcc 1267Leu Ala Val His Val Asp Val Val Thr Pro Asn Ile Pro Glu Leu Ala

375 380 385gtg ttg tgc gac agt gct cct gcc atc acc atg gat gag gcc att gct 1315Val Leu Cys Asp Ser Ala Pro Ala Ile Thr Met Asp Glu Ala Ile Ala390 395 400 405cag gct cag gga ttt gcg cgg act cat gac acc atc gtc att gtc aag 1363Gln Ala Gln Gly Phe Ala Arg Thr His Asp Thr Ile Val Ile Val Lys

410 415 420ggt gga cat ctg act ggc gcg ctt gct gat aac gct gtc gtg cgc ccc 1411Gly Gly His Leu Thr Gly Ala Leu Ala Asp Asn Ala Val Val Arg Pro

425 430 435gac ggc tcg gtg ttc cag gtg gaa aac ctg cgt gtc aac acc acc aac 1459Asp Gly Ser Val Phe Gln Val Glu Asn Leu Arg Val Asn Thr Thr Asn

440 445 450tcc cat ggc aca ggc tgt tcg ctc tct gcg tca ctt gcc acc aag atc 1507Ser His Gly Thr Gly Cys Ser Leu Ser Ala Ser Leu Ala Thr Lys Ile

455460465 gcc gcc ggc gaa agc gtg gaa 1528Ala Ala Gly Glu Ser Val Glu 470475<210>1124<211>476<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1124Met Cys Glu Arg Pro Glu Lys Tyr Val Thr Asp Phe Ser Leu Tyr Leu 151015 Val Thr Asp Pro Val Leu Gly Gly Gly Pro Lys Lys Val Ala Gly Ile

20 25 30Val Asp Ser Ala Ile Ser Gly Gly Val Ser Val Val Gln Leu Arg Asp

35 40 45Lys Asn Ser Gly Val Glu Asp Val Arg Ala Ala Ala Lys Glu Leu Lys

50 55 60Glu Leu Cys Asp Ala Arg Gly Val Ala Leu Val Val Asn Asp Tyr Leu 65 70 75 80Asp Ile Ala Val Glu Leu Gly Leu His Leu His Ile Gly Gln Gly Asp

85 90 95Thr Pro Tyr Thr Gln Ala Arg Glu Leu Leu Pro Ala His Leu Glu Leu

100 105 110Gly Leu Ser Ile Glu Asn Leu Asp Gln Leu His Ala Val Ile Ala Gln

115 120 125Cys Ala Glu Thr Gly Val Ala Leu Pro Asp Val Ile Gly Ile Gly Pro

130 135 140Val Ala Ser Thr Ala Thr Lys Pro Asp Ala Ala Pro Ala Leu Gly Val145 150 155 160Glu Gly Ile Ala Glu Ile Ala Ala Val Ala Gln Asp His Gly Ile Ala

165 170 175Ser Val Ala Ile Gly Gly Val Gly Leu Arg Asn Ala Ala Glu Leu Ala

180 185 190Ala Thr Pro Ile Asp Gly Leu Cys Val Val Ser Glu Ile Met Thr Ala

195 200 205Ala Asn Pro Ala Ala Ala Ala Thr Arg Leu Arg Thr Ala Phe Gln Pro

210 215 220Thr Phe Ser Pro Glu Thr Gln Thr Glu Leu Ser Gln Thr Glu Leu Gln225 230 235 240Gly Ala Phe Val Asn Ser Pro Ser Ala Pro Arg Val Leu Ser Ile Ala

245 250 255Gly Thr Asp Pro Thr Gly Gly Ala Gly Ile Gln Ala Asp Leu Lys Ser

260 265 270Ile Ala Ala Gly Gly Gly Tyr Gly Met Cys Val VaI Thr Ser Leu Val

275 280 285Ala Gln Asn Thr His Gly Val Asn Thr Ile His Thr Pro Pro Leu Thr

290 295 300Phe Leu Glu Glu Gln Leu Glu Ala Val Phe Ser Asp Val Thr Val Asp305 310 315 320Ala Ile Lys Leu Gly Met Leu Gly Ser Ala Asp Thr Val Asp Leu Val

325 330 335Ala Ser Trp Leu Gly Ser His Glu His Gly Pro Val Val Leu Asp Pro

340 345 350Val Met Ile Ala Thr Ser Gly Asp Arg Leu Leu Asp Ala Ser Ala Glu

355 360 365Glu Ser Leu Arg Arg Leu Ala Val His Val Asp Val Val Thr Pro Asn

370 375 380Ile Pro Glu Leu Ala Val Leu Cys Asp Ser Ala Pro Ala Ile Thr Met385 390 395 400Asp Glu Ala Ile Ala Gln Ala Gln Gly Phe Ala Arg Thr His Asp Thr

405 410 415Ile Val Ile Val Lys Gly Gly His Leu Thr Gly Ala Leu Ala Asp Asn

420 425 430Ala Val Val Arg Pro Asp Gly Ser Val Phe Gln Val Glu Asn Leu Arg

435 440 445Val Asn Thr Thr Asn Ser His Gly Thr Gly Cys Ser Leu Ser Ala Ser

450455460 Leu Ala Thr Lys Ile Ala Ala Gly Glu Ser Val Glu 465470475<210>1125<211>795<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (772)<223>RXN01617<400>1125tcagaagcta ccggcggcgc cggcatccag gttgatttga agaccttcca gcatttaaga 60tgtttatggc attgggtcca tcacatgctt gggtggcctt ttg atc cta aag aca 115

Leu Ile Leu Lys Thr

1 5act gga atc acc gtt ttg tcc cgg ttt gat gcg cag gtt atc gct aat 163Thr Gly Ile Thr Val Leu Ser Arg Phe Asp Ala Gln Val Ile Ala Asn

10 15 20cag att gag gcc gcc acc gca gcg cac gat ctt gat gtg gtg aag atc 211Gln Ile Glu Ala Ala Thr Ala Ala His Asp Leu Asp Val Val Lys Ile

25 30 35ggt atg ttg ggt act cct gca acg atc gat act gtg gca acc gct ttg 259Gly Met Leu Gly Thr Pro Ala Thr Ile Asp Thr Val Ala Thr Ala Leu

40 45 50gag gaa aac agc ttc aag cac gtt gtc cta gac ccg gta ctg atc tgc 307Glu Glu Asn Ser Phe Lys His Val Val Leu Asp Pro Val Leu Ile Cys

55 60 65aag ggc cag gag ccc ggc gcg gca ctt gat act gac act gcc ctt cgc 355Lys Gly Gln Glu Pro Gly Ala Ala Leu Asp Thr Asp Thr Ala Leu Arg 70 75 80 85gcg aag gtg ctg cca cag gca acc gtg gtt act cca aac aac ttc gag 403Ala Lys Val Leu Pro Gln Ala Thr Val Val Thr Pro Asn Asn Phe Glu

90 95 100gcc acc acc ctg tct ggc cta gac aag ctg gag acc atc gac gac ctg 451Ala Thr Thr Leu Ser Gly Leu Asp Lys Leu Glu Thr Ile Asp Asp Leu

105 110 115aag gaa gca gcc cgc ctc att cat gag caa gga cct cag tac gtc gtt 499Lys Glu Ala Ala Arg Leu Ile His Glu Gln Gly Pro Gln Tyr Val Val

120 125 130gtt aag ggt ggc atc gac ttc cca ggc gac aac gct gtg gac gta ctt 547Val Lys Gly Gly Ile Asp Phe Pro Gly Asp Asn Ala Val Asp Val Leu

135 140 145ttc gac ggc acc gac tac cac gtg ttc tct gaa cca aag atc ggc gac 595Phe Asp Gly Thr Asp Tyr His Val Phe Ser Glu Pro Lys Ile Gly Asp150 155 160 165gag cgc gtc tcc ggc gct ggc tgt acc ttc gca gct gtc atc acc gca 643Glu Arg Val Ser Gly Ala Gly Cys Thr Phe Ala Ala Val Ile Thr Ala

170 175 180gag ctg gcc aag ggc aac tct gcc gtt gat gca gtg acc acc gct aag 691Glu Leu Ala Lys Gly Asn Ser Ala Val Asp Ala Val Thr Thr Ala Lys

185 190 195cgc gta gtc acc cgc gca gtg aag gac gct gtc gca tcc aac gca ccg 739Arg Val Val Thr Arg Ala Val Lys Asp Ala Val Ala Ser Asn Ala Pro

200 205 210ttt acc tct gtg tgg ttg gcg gaa gac aac aag tagaaatctt aaacaagctc 792Phe Thr Ser Val Trp Leu Ala Glu Asp Asn Lys

215220 cct 795<210>1126<211>224<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1126Leu Ile Leu Lys Thr Thr Gly Ile Thr Val Leu Ser Arg Phe Asp Ala 151015 Gln Val Ile Ala Asn Gln Ile Glu Ala Ala Thr Ala Ala His Asp Leu

20 25 30Asp Val Val Lys Ile Gly Met Leu Gly Thr Pro Ala Thr Ile Asp Thr

35 40 45Val Ala Thr Ala Leu Glu Glu Asn Ser Phe Lys His Val Val Leu Asp

50 55 60Pro Val Leu Ile Cys Lys Gly Gln Glu Pro Gly Ala Ala Leu Asp Thr 65 70 75 80Asp Thr Ala Leu Arg Ala Lys Val Leu Pro Gln Ala Thr Val Val Thr

85 90 95Pro Asn Asn Phe Glu Ala Thr Thr Leu Ser Gly Leu Asp Lys Leu Glu

100 105 110Thr Ile Asp Asp Leu Lys Glu Ala Ala Arg Leu Ile His Glu Gln Gly

115 120 125Pro Gln Tyr Val Val Val Lys Gly Gly Ile Asp Phe Pro Gly Asp Asn

130 135 140Ala Val Asp Val Leu Phe Asp Gly Thr Asp Tyr His Val Phe Ser Glu145 150 155 160Pro Lys Ile Gly Asp Glu Arg Val Ser Gly Ala Gly Cys Thr Phe Ala

165 170 175Ala Val Ile Thr Ala Glu Leu Ala Lys Gly Asn Ser Ala Val Asp Ala

180 185 190Val Thr Thr Ala Lys Arg Val Val Thr Arg Ala Val Lys Asp Ala Val

195 200205Ala Ser Asn Ala Pro Phe Thr Ser Val Trp Leu Ala Glu Asp Asn Lys

210215220<210>1127<211>638<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) } (615)<223>FRXA01617<400>1127gct aat cag att gag gcc gcc acc gca gcg cac gat ctt gat gtg gtg 48Ala Asn Gln Ile Glu Ala Ala Thr Ala Ala His Asp Leu Asp Val Val 151015 aag atc ggt atg ttg ggt act cct gca acg atc gat act gtg gca acc 96Lys Ile Gly Met Leu Gly Thr Pro Ala Thr Ile Asp Thr Val Ala Thr<400>1127gct aat cag att gag gcc gcc acc gca gcg cac gat ctt gat gtg gtg

20 25 30gct ttg gag gaa aac agc ttc aag cac gtt gtc cta gac ccg gta ctg 144Ala Leu Glu Glu Asn Ser Phe Lys His Val Val Leu Asp Pro Val Leu

35 40 45atc tgc aag ggc cag gag ccc ggc gcg gca ctt gat act gac act gcc 192Ile Cys Lys Gly Gln Glu Pro Gly Ala Ala Leu Asp Thr Asp Thr Ala

50 55 60ctt cgc gcg aag gtg ctg cca cag gca acc gtg gtt act cca aac aac 240Leu Arg Ala Lys Val Leu Pro Gln Ala Thr Val Val Thr Pro Asn Asn 65 70 75 80ttc gag gcc acc acc ctg tct ggc cta gac aag ctg gag acc atc gac 288Phe Glu Ala Thr Thr Leu Ser Gly Leu Asp Lys Leu Glu Thr Ile Asp

85 90 95gac ctg aag gaa gca gcc cgc ctc att cat gag caa gga cct cag tac 336Asp Leu Lys Glu Ala Ala Arg Leu Ile His Glu Gln Gly Pro Gln Tyr

100 105 110gtc gtt gtt aag ggt ggc atc gac ttc cca ggc gac aac gct gtg gac 384Val Val Val Lys Gly Gly Ile Asp Phe Pro Gly Asp Asn Ala Val Asp

115 120125gta ctt ttc gac ggc acc gac tac cac gtg ttc tct gaa cca aag atc 432Val Leu Phe Asp Gly Thr Asp Tyr His Val Phe Ser Glu Pro Lys Ile

130 135 140ggc gac gag cgc gtc tcc ggc gct ggc tgt acc ttc gca gct gtc atc 480Gly Asp Glu Arg Val Ser Gly Ala Gly Cys Thr Phe Ala Ala Val Ile145 150 155 160acc gca gag ctg gcc aag ggc aac tct gcc gtt gat gca gtg acc acc 528Thr Ala Glu Leu Ala Lys Gly Asn Ser Ala Val Asp Ala Val Thr Thr

165 170 175gct aag cgc gta gtc acc cgc gca gtg aag gac gct gtc gca tcc aac 576Ala Lys Arg Val Val Thr Arg Ala Val Lys Asp Ala Val Ala Ser Asn

180 185 190gca ccg ttt acc tct gtg tgg ttg gcg gaa gac aac aag tagaaatctt 625Ala Pro Phe Thr Ser Val Trp Leu Ala Glu Asp Asn Lys

195200205 aaacaagctc cct 638<210>1128<211>205<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1128Ala Asn Gln Ile Glu Ala Ala Thr Ala Ala His Asp Leu Asp Val Val 151015 Lys Ile Gly Met Leu Gly Thr Pro Ala Thr Ile Asp Thr Val Ala Thr

20 25 30Ala Leu Glu Glu Asn Ser Phe Lys His Val Val Leu Asp Pro Val Leu

35 40 45Ile Cys Lys Gly Gln Glu Pro Gly Ala Ala Leu Asp Thr Asp Thr Ala

50 55 60Leu Arg Ala Lys Val Leu Pro Gln Ala Thr Val Val Thr Pro Asn Asn 65 70 75 80Phe Glu Ala Thr Thr Leu Ser Gly Leu Asp Lys Leu Glu Thr Ile Asp

85 90 95Asp Leu Lys Glu Ala Ala Arg Leu Ile His Glu Gln Gly Pro Gln Tyr

100 105 110Val Val Val Lys Gly Gly Ile Asp Phe Pro Gly Asp Asn Ala Val Asp

115 120 125Val Leu Phe Asp Gly Thr Asp Tyr His Val Phe Ser Glu Pro Lys Ile

130 135 140Gly Asp Glu Arg Val Ser Gly Ala Gly Cys Thr Phe Ala Ala Val Ile145 150 155 160Thr Ala Glu Leu Ala Lys Gly Asn Ser Ala Val Asp Ala Val Thr Thr

165 170 175Ala Lys Arg Val Val Thr Arg Ala Val Lys Asp Ala Val Ala Ser Asn

180 185 190Ala Pro Phe Thr Ser Val Trp Leu Ala Glu Asp Asn Lys

195200205<210>1129<211>792<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (769)<223>RXC01600<400>112 1129tgagtacaaa tctcgtccaa cccatgctca tccactgttt tacggcctgg tgaagaccgc 60tttggagctg cgtgtccacc cttagatcta caatgtgatc atg gtt tcg aag atg 115

Met Val Ser Lys Met

1 5cac att ccc ggt acc cat gag ttc acg gtg aca gat act gaa ctg ttg 163His Ile Pro Gly Thr His Glu Phe Thr Val Thr Asp Thr Glu Leu Leu

10 15 20tta gag tcc cca att ttg ggc gtt cgt cga gat tca ttg atc atg ccg 211Leu Glu Ser Pro Ile Leu Gly Val Arg Arg Asp Ser Leu Ile Met Pro

25 30 35ggt ggt tcc act gcc cgc cgt gaa gtg gtt gaa cac ttt ggg gcg gtc 259Gly Gly Ser Thr Ala Arg Arg Glu Val Val Glu His Phe Gly Ala Val

40 45 50gca gtg gtt gcc ttt gat ggt gaa aac att gcg atg gtc aag cag tac 307Ala Val Val Ala Phe Asp Gly Glu Asn Ile Ala Met Val Lys Gln Tyr

55 60 65cgt cgc agc gtg ggg gat tcc ttg tgg gag ctg cct gca ggt ttg ttg 355Arg Arg Ser Val Gly Asp Ser Leu Trp Glu Leu Pro Ala Gly Leu Leu 70 75 80 85gat att gct gat gag gat gaa ctc acg ggc gcg cag cgc gag ctc atg 403Asp Ile Ala Asp Glu Asp Glu Leu Thr Gly Ala Gln Arg Glu Leu Met

90 95 100gag gag gct ggt ttg gag gcc agt gag tgg tcc gtg ctc act gat ttg 451Glu Glu Ala Gly Leu Glu Ala Ser Glu Trp Ser Val Leu Thr Asp Leu

105 110 115att acc tcg cct ggt ttc tgc gat gaa gcg gtg cgt gtc ttt cta gcc 499Ile Thr Ser Pro Gly Phe Cys Asp Glu Ala Val Arg Val Phe Leu Ala

120 125 130cga ggc ctc aca aag gtt gag cgc ccg aag gtt atg ggc gat gaa gaa 547Arg Gly Leu Thr Lys Val Glu Arg Pro Lys Val Met Gly Asp Glu Glu

135 140 145gcg gac atg att aac cag tgg gtt ccg cta cat gag gca gtg gga atg 595Ala Asp Met Ile Asn Gln Trp Val Pro Leu His Glu Ala Val Gly Met150 155 160 165gtg ttt agt ggc cag ttg gtt aac tcc att gcc att gcg ggt gtc atg 643Val Phe Ser Gly Gln Leu Val Asn Ser Ile Ala Ile Ala Gly Val Met

170 175 180gct gct gat gct gtg att gcg ggt cgt gcg tct gcg cgt gcc gtc acc 691Ala Ala Asp Ala Val Ile Ala Gly Arg Ala Ser Ala Arg Ala Val Thr

185 190 195gcg ccg ttt acc tat cgc cct acg gcg ttg gcg cag cgt cga aaa gcg 739Ala Pro Phe Thr Tyr Arg Pro Thr Ala Leu Ala Gln Arg Arg Lys Ala

200 205 210cac ggc att gtt cct gac atg aaa aaa cta tgaaggctcg cgttttagcg 789His Gly Ile Val Pro Asp Met Lys Lys Leu

215220 aaa 792<210>1130<211>223<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1130Met Val Ser Lys Met His Ile Pro Gly Thr His Glu Phe Thr Val Thr 151015 Asp Thr Glu Leu Leu Leu Glu Ser Pro Ile Leu Gly Val Arg Arg Asp

20 25 30Ser Leu Ile Met Pro Gly Gly Ser Thr Ala Arg Arg Glu Val Val Glu

35 40 45His Phe Gly Ala Val Ala Val Val Ala Phe Asp Gly Glu Asn Ile Ala

50 55 60Met Val Lys Gln Tyr Arg Arg Ser Val Gly Asp Ser Leu Trp Glu Leu 65 70 75 80Pro Ala Gly Leu Leu Asp Ile Ala Asp Glu Asp Glu Leu Thr Gly Ala

85 90 95Gln Arg Glu Leu Met Glu Glu Ala Gly Leu Glu Ala Ser Glu Trp Ser

100 105 110Val Leu Thr Asp Leu Ile Thr Ser Pro Gly Phe Cys Asp Glu Ala Val

115 120 125Arg Val Phe Leu Ala Arg Gly Leu Thr Lys Val Glu Arg Pro Lys Val

130 135 140Met Gly Asp Glu Glu Ala Asp Met Ile Asn Gln Trp Val Pro Leu His145 150 155 160Glu Ala Val Gly Met Val Phe Ser Gly Gln Leu Val Asn Ser Ile Ala

165170 175Ile Ala Gly Val Met Ala Ala Asp Ala Val Ile Ala Gly Arg Ala Ser

180 185 190Ala Arg Ala Val Thr Ala Pro Phe Thr Tyr Arg Pro Thr Ala Leu Ala

195 200 205Gln Arg Arg Lys Ala His Gly Ile Val Pro Asp Met Lys Lys Leu

210215220<210>1131<211>726<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (703)<223>RXC01622<400>1131aaggcgtggg cgtttttgaa ggagcttcgt ttggagcgcg gtcctttgga tcgtgaagtt 60gccatcgcag agctgaagag ctggtgggaa ggagaaaaca atg agt gat ttt tat 115

Met Ser Asp Phe Tyr

1 5gcc gac agg ttg ttt aac gcg atg gag cgc aat gag gta gct cca ggc 163Ala Asp Arg Leu Phe Asn Ala Met Glu Arg Asn Glu Val Ala Pro Gly

10 15 20atg ttg ttg gtg gct gcg ccc gat atg gcg tcg gag gat ttt gag cgc 211Met Leu Leu Val Ala Ala Pro Asp Met Ala Ser Glu Asp Phe Glu Arg

25 30 35agc atc gtg ttg atc atc gag cat tct cct gcc acc act ttt ggt gtg 259Ser Ile Val Leu Ile Ile Glu His Ser Pro Ala Thr Thr Phe Gly Val

40 45 50aac att tct tca cgt tcc gat gtt gct gtg gcc aat gtg ttg ccc gag 307Asn Ile Ser Ser Arg Ser Asp Val Ala Val Ala Asn Val Leu Pro Glu

55 60 65tgg gtg gac ctc acc tcg aag cca cag gca ctg tac atc ggt ggg ccg 355Trp Val Asp Leu Thr Ser Lys Pro Gln Ala Leu Tyr Ile Gly Gly Pro 70 7580 85ttg agc cag cag gct gtg gtt ggt ttg ggc gtg acc aag ccg ggc gtg 403Leu Ser Gln Gln Ala Val Val Gly Leu Gly Val Thr Lys Pro Gly Val

90 95 100gat att gaa aat tcc acc agc ttc aac aag ctc gcc aac cgc ctg gtg 451Asp Ile Glu Asn Ser Thr Ser Phe Asn Lys Leu Ala Asn Arg Leu Val

105 110 115cac gtg gat ctg cgt tct gca cct gaa gat gtg gct gat gat ctt gag 499His Val Asp Leu Arg Ser Ala Pro Glu Asp Val Ala Asp Asp Leu Glu

120 125 130ggc atg cgc ttt ttt gcg ggc tac gcg gag tgg gct ccg ggc cag ctc 547Gly Met Arg Phe Phe Ala Gly Tyr Ala Glu Trp Ala Pro Gly Gln Leu

135 140 145aac gag gaa att gag cag ggt gat tgg ttc gtc aca cct gcg ttg ccg 595Asn Glu Glu Ile Glu Gln Gly Asp Trp Phe Val Thr Pro Ala Leu Pro150 155 160 165tcg gac att atc gcg ccg ggc cgc gtc gat att tgg ggc gac gtg atg 643Ser Asp Ile Ile Ala Pro Gly Arg Val Asp Ile Trp Gly Asp Val Met

170 175 180cgt cga caa gca atg cct ttg ccg ttg tat tcc acg ttt ccg tcg gac 691Arg Arg Gln Ala Met Pro Leu Pro Leu Tyr Ser Thr Phe Pro Ser Asp

185 190 195cct tca gat aat tagatgagtt ccgaaaattt aaa 726Pro Ser Asp Asn

200<210>1132<211>201<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1132Met Ser Asp Phe Tyr Ala Asp Arg Leu Phe Asn Ala Met Glu Arg Asn 151015 Glu Val Ala Pro Gly Met Leu Leu Val Ala Ala Pro Asp Met Ala Ser

20 25 30Glu Asp Phe Glu Arg Ser Ile Val Leu Ile Ile Glu His Ser Pro Ala

35 40 45Thr Thr Phe Gly Val Asn Ile Ser Ser Arg Ser Asp Val Ala Val Ala

50 55 60Asn Val Leu Pro Glu Trp Val Asp Leu Thr Ser Lys Pro Gln Ala Leu 65 70 75 80Tyr Ile Gly Gly Pro Leu Ser Gln Gln Ala Val Val Gly Leu Gly Val

85 90 95Thr Lys Pro Gly Val Asp Ile Glu Asn Ser Thr Ser Phe Asn Lys Leu

100 105 110Ala Asn Arg Leu Val His Val Asp Leu Arg Ser Ala Pro Glu Asp Val

115 120 125Ala Asp Asp Leu Glu Gly Met Arg Phe Phe Ala Gly Tyr Ala Glu Trp

130 135 140Ala Pro Gly Gln Leu Asn Glu Glu Ile Glu Gln Gly Asp Trp Phe Val145 150 155 160Thr Pro Ala Leu Pro Ser Asp Ile Ile Ala Pro Gly Arg Val Asp Ile

165 170 175Trp Gly Asp Val Met Arg Arg Gln Ala Met Pro Leu Pro Leu Tyr Ser

180 185 190Thr Phe Pro Ser Asp Pro Ser Asp Asn

195200<210>1133<211>1827<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1804)<223>RXC00128<400>1133ccattttccg tttggtcttg cctaaagaac cgcatggaaa ttatcgtgaa gcaccgatcc 60cgttgatcgc tccagagaca ccgtgggaag gggagcagca gtg agt aaa att tcg 115

Val Ser Lys Ile Ser

1 5acg aaa ctg aag gcc ctc acc gcg gtg ctg tct gtg acc act ctg gtg 163Thr Lys Leu Lys Ala Leu Thr Ala Val Leu Ser Val Thr Thr Leu Val

10 15 20gct ggg tgt tcc acg ctt ccg cag aac acg gat ccg caa gtg ctg cgc 211Ala Gly Cys Ser Thr Leu Pro Gln Asn Thr Asp Pro Gln Val Leu Arg

25 30 35tca ttt tcc ggg tcc caa agc aca caa gag ata gca ggg ccg acc ccg 259Ser Phe Ser Gly Ser Gln Ser Thr Gln Glu Ile Ala Gly Pro Thr Pro

40 45 50aat caa gat ccg gat ttg ttg atc cgc ggc ttc ttc agc gca ggt gcg 307Asn Gln Asp Pro Asp Leu Leu Ile Arg Gly Phe Phc Ser Ala Gly Ala

55 60 65tat ccg act cag cag tat gaa gcg gcg aag gcg tat ctg acg gaa ggg 355Tyr Pro Thr Gln Gln Tyr Glu Ala Ala Lys Ala Tyr Leu Thr Glu Gly 70 75 80 85acg cgc agc acg tgg aat ccg gct gcg tcg act cgt att ttg gat cgc 403Thr Arg Ser Thr Trp Asn Pro Ala Ala Ser Thr Arg Ile Leu Asp Arg

90 95 100att gat ctg aac act ctg cca ggt tcg acg aat gcg gaa cga acg att 451Ile Asp Leu Asn Thr Leu Pro Gly Ser Thr Asn Ala Glu Arg Thr Ile

105 110 115gcg atc cgt gga acg cag gtc gga acg ttg ctc agc ggt ggc gtg tat 499Ala Ile Arg Gly Thr Gln Val Gly Thr Leu Leu Ser Gly Gly Val Tyr

120 125 130cag ccg gag aat gcg gag ttt gaa gct gag atc acg atg cgt cgg gaa 547Gln Pro Glu Asn Ala Glu Phe Glu Ala Glu Ile Thr Met Arg Arg Glu

135 140 145gat ggg gag tgg cgt atcgat gct ttg ccg gac ggg att tta tta gag 595Asp Gly Glu Trp Arg Ile Asp Ala Leu Pro Asp Gly Ile Leu Leu Glu150 155 160 165aga aac gat ctg cgg aac cat tac act ccg cac gat gtg tat ttc ttt 643Arg Asn Asp Leu Arg Asn His Tyr Thr Pro His Asp Val Tyr Phe Phe

170 175 180gat cct tct ggc cag gtg ttg gtg ggg gat cgg cgt tgg ttg ttc aat 691Asp Pro Ser Gly Gln Val Leu Val Gly Asp Arg Arg Trp Leu Phe Asn

185 190 195gag tcg cag tcg atg tcc acg gtg ctg atg gcc ctt ctg gtt aat ggt 739Glu Ser Gln Ser Met Ser Thr Val Leu Met Ala Leu Leu Val Asn Gly

200 205 210cct tcg ccg gca att tct cct ggt gtg gtc aat cag ctg tcc acg gat 787Pro Ser Pro Ala Ile Ser Pro Gly Val Val Asn Gln Leu Ser Thr Asp

215 220 225gcg tcg ttc gtg ggg ttc aat gat ggg gag tat cag ttc act ggt ttg 835Ala Ser Phe Val Gly Phe Asn Asp Gly Glu Tyr Gln Phe Thr Gly Leu230 235 240 245gga aat ttg gat gat gat gcg cgt ttg cgt ttc gcc gcc cag gcc gtg 883Gly Asn Leu Asp Asp Asp Ala Arg Leu Arg Phe Ala Ala Gln Ala Val

250 255 260tgg acg ttg gcg cat gct gat gtc gca ggc ccc tac act ttg gtc gct 931Trp Thr Leu Ala His Ala Asp Val Ala Gly Pro Tyr Thr Leu Val Ala

265 270 275gac ggc gcg ccg ttg ctg tcg gag ttc cca acg ctc acc acc gat gac 979Asp Gly Ala Pro Leu Leu Ser Glu Phe Pro Thr Leu Thr Thr Asp Asp

280 285 290ctc gcc gaa tac aac cca gag gct tac acc aac acg gtg tcc acg ttg 1027Leu Ala Glu Tyr Asn Pro Glu Ala Tyr Thr Asn ThrVal Ser Thr Leu

295 300 305ttt gcg ttg cag gat gga tcg ttg tcg agg gtc agt tcc ggc aat gtg 1075Phe Ala Leu Gln Asp Gly Ser Leu Ser Arg Val Ser Ser Gly Asn Val310 315 320 325agt cca cta cag ggc att tgg agc ggt gga gat atc gat tct gca gcg 1123Ser Pro Leu Gln Gly Ile Trp Ser Gly Gly Asp Ile Asp Ser Ala Ala

330 335 340att tcc tcc tcc gcc aat gtg gtg gca gcg gta cgc cac gaa aac aac 1171Ile Ser Ser Ser Ala Asn Val Val Ala Ala Val Arg His Glu Asn Asn

345 350 355gag gca gtg ctt act gtt ggc tcc atg gaa ggc gtg act tca gat gcg 1219Glu Ala Val Leu Thr Val Gly Ser Met Glu Gly Val Thr Ser Asp Ala

360 365 370ttg agg agt gaa acg atc act cgt ccc acc ttt gaa tac gcg tcg agt 1267Leu Arg Ser Glu Thr Ile Thr Arg Pro Thr Phe Glu Tyr Ala Ser Ser

375 380 385ggg ttg tgg gct gtg gtg gat ggg gag acg cct gtc cga gtc gca cga 1315Gly Leu Trp Ala Val Val Asp Gly Glu Thr Pro Val Arg Val Ala Arg390 395 400 405tcg gca aca acc ggt gag ctc gtc cag acg gag gcg gag att gtg ctg 1363Ser Ala Thr Thr Gly Glu Leu Val Gln Thr Glu Ala Glu Ile Val Leu

410 415 420cca agg gat gtg acg ggt ccg atc tct gaa ttc caa ctg tca cga act 1411Pro Arg Asp Val Thr Gly Pro Ile Ser Glu Phe Gln Leu Ser Arg Thr

425 430 435ggg gtc cgg gcc gcc atg atc att gaa ggc aag gtg tac gtg ggc gtc 1459Gly Val Arg Ala Ala Met Ile Ile Glu Gly Lys Val Tyr Val Gly Val

440 445 450gta acg cgt cct ggt ccg ggc gag cgg cgc gtg aca aat atc acg gag 1507Val Thr Arg Pro Gly Pro Gly Glu Arg Arg Val Thr Asn Ile Thr Glu

455 460 465gtg gcg ccg agc ttg ggc gag gcg gcg ctg tcg atc aac tgg cgc cca 1555Val Ala Pro Ser Leu Gly Glu Ala Ala Leu Ser Ile Asn Trp Arg Pro470 475 480 485gac ggc att ttg ctt gtg ggc acg tca att cca gag acg ccg ctg tgg 1603Asp Gly Ile Leu Leu Val Gly Thr Ser Ile Pro Glu Thr Pro Leu Trp

490 495 500cgc gtc gag cag gac gga tcg gcg att tcg tcg atg ccg agc ggg aat 1651Arg Val Glu Gln Asp Gly Ser Ala Ile Ser Ser Met Pro Ser Gly Asn

505 510 515ctc agc gcg ccg gtg gtg gcg gtg gca agt tcc gcg acg acg gtc tac 1699Leu Ser Ala Pro Val Val Ala Val Ala Ser Ser Ala Thr Thr Val Tyr

520 525 530gtc act gat tcg cat gcg atg ctt cag ctg ccg act gcc gat aat gat 1747Val Thr Asp Ser His Ala Met Leu Gln Leu Pro Thr Ala Asp Asn Asp

535540545 att tgg cgc gag gtg ccc ggt ttg ctg ggc acg cgt gcg gcg ccg gtg 1795Ile Trp Arg Glu Val Pro Gly Leu Leu Gly Thr Arg Ala Ala Pro Val 550555560565 gtt gcg tac tgatggagct gttcttcccg cgc 1827Val Ala Tyr<210>1134<211>568<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1134Val Ser Lys Ile Ser Thr Lys Leu Lys Ala Leu Thr Ala Val Leu Ser 151015 Val Thr Thr Leu Val Ala Gly Cys Ser Thr Leu Pro Gln Asn Thr Asp

20 25 30Pro Gln Val Leu Arg Ser Phe Ser Gly Ser Gln Ser Thr Gln Glu Ile

35 40 45Ala Gly Pro Thr Pro Asn Gln Asp Pro Asp Leu Leu Ile Arg Gly Phe

50 55 60Phe Ser Ala Gly Ala Tyr Pro Thr Gln Gln Tyr Glu Ala Ala Lys Ala 65 70 75 80Tyr Leu Thr Glu Gly Thr Arg Ser Thr Trp Asn Pro Ala Ala Ser Thr

85 90 95Arg Ile Leu Asp Arg Ile Asp Leu Asn Thr Leu Pro Gly Ser Thr Asn

100 105 110Ala Glu Arg Thr Ile Ala Ile Arg Gly Thr Gln Val Gly Thr Leu Leu

115 120 125Ser Gly Gly Val Tyr Gln Pro Glu Asn Ala Glu Phe Glu Ala Glu Ile

130 135 140Thr Met Arg Arg Glu Asp Gly Glu Trp Arg Ile Asp Ala Leu Pro Asp145 150 155 160Gly Ile Leu Leu Glu Arg Asn Asp Leu Arg Asn His Tyr Thr Pro His

165 170 175Asp Val Tyr Phe Phe Asp Pro Ser Gly Gln Val Leu Val Gly Asp Arg

180 185 190Arg Trp Leu Phe Asn Glu Ser Gln Ser Met Ser Thr Val Leu Met Ala

195 200 205Leu Leu Val Asn Gly Pro Ser Pro Ala Ile Ser Pro Gly Val Val Asn

210 215 220Gln Leu Ser Thr Asp Ala Ser Phe Val Gly Phe Asn Asp Gly Glu Tyr225 230 235 240Gln Phe Thr Gly Leu Gly Asn Leu Asp Asp Asp Ala Arg Leu Arg Phe

245 250 255Ala Ala Gln Ala Val Trp Thr Leu Ala His Ala Asp Val Ala Gly Pro

260 265 270Tyr Thr Leu Val Ala Asp Gly Ala Pro Leu Leu Ser Glu Phe Pro Thr

275 280 285Leu Thr Thr Asp Asp Leu Ala Glu Tyr Asn Pro Glu Ala Tyr Thr Asn

290 295 300Thr Val Ser Thr Leu Phe Ala Leu Gln Asp Gly Ser Leu Ser Arg Val305 310 315 320Ser Ser Gly Asn Val Ser Pro Leu Gln Gly Ile Trp Ser Gly Gly Asp

325 330 335Ile Asp Ser Ala Ala Ile Ser Ser Ser Ala Asn Val Val Ala Ala Val

340 345 350Arg His Glu Asn Asn Glu Ala Val Leu Thr Val Gly Ser Met Glu Gly

355 360 365Val Thr Ser Asp Ala Leu Arg Ser Glu Thr Ile Thr Arg Pro Thr Phe

370 375 380Glu Tyr Ala Ser Ser Gly Leu Trp Ala Val Val Asp Gly Glu Thr Pro385 390 395 400Val Arg Val Ala Arg Ser Ala Thr Thr Gly Glu Leu Val Gln Thr Glu

405 410 415Ala Glu Ile Val Leu Pro Arg Asp Val Thr Gly Pro Ile Ser Glu Phe

420 425 430Gln Leu Ser Arg Thr Gly Val Arg Ala Ala Met Ile Ile Glu Gly Lys

435 440 445Val Tyr Val Gly Val Val Thr Arg Pro Gly Pro Gly Glu Arg Arg Val

450 455 460Thr Asn Ile Thr Glu Val Ala Pro Ser Leu Gly Glu Ala Ala Leu Ser465 470 475 480Ile Asn Trp Arg Pro Asp Gly Ile Leu Leu Val Gly Thr Ser Ile Pro

485 490 495Glu Thr Pro Leu Trp Arg Val Glu Gln Asp Gly Ser Ala Ile Ser Ser

500 505 510Met Pro Ser Gly Asn Leu Ser Ala Pro Val Val Ala Val Ala Ser Ser

515 520 525Ala Thr Thr Val Tyr Val Thr Asp Ser His Ala Met Leu Gln Leu Pro

530 535 540Thr Ala Asp Asn Asp Ile Trp Arg Glu Val Pro Gly Leu Leu Gly Thr545 550 555 560Arg Ala Ala Pro Val Val Ala Tyr

565<210>1135<211>555<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (532)<223>RXC01709<400>1135gcaagtggaa ccacgatggg aacggtaact gctgccgctg cggtattact cgtagtttca 60gaaattaggt gtcgatgcag caatacggaa ctttgccaat gtg ttt gaa caa gct 115

Val Phe Glu Gln Ala

1 5ctc ggg ctc acc acc ctt gca caa aca gct gga gcg ggc gca gcg ggg 163Leu Gly Leu Thr Thr Leu Ala Gln Thr Ala Gly Ala Gly Ala Ala Gly

10 15 20ggc ttg ggt ttc atg gca atg gcg ttg ttg tct gca ggg atg cgc tcc 211Gly Leu Gly Phe Met Ala Met Ala Leu Leu Ser Ala Gly Met Arg Ser

25 30 35ggc gtg gac atg att ctt aat gaa acc ggg ggt gaa aag atg ctt gca 259Gly Val Asp Met Ile Leu Asn Glu Thr Gly Gly Glu Lys Met Leu Ala

40 45 50cag gca gat tta gtc atc act gga gaa gga cgc att gat gca cag acc 307Gln Ala Asp Leu Val Ile Thr Gly Glu Gly Arg Ile Asp Ala Gln Thr

55 60 65ctc agc ggg aaa gct cct act gga atc gcc aaa cgg gca cgt gcg aaa 355Leu Ser Gly Lys Ala Pro Thr Gly Ile Ala Lys Arg Ala Arg Ala Lys 70 75 80 85gga att cca gta ctg gcg gtt tgt ggg cag agc cta ttg ggt cca gca 403Gly Ile Pro Val Leu Ala Val Cys Gly Gln Ser Leu Leu Gly Pro Ala

90 95 100atc tca aat gag cta ttt gaa gac atc tac agc ttt acc gat ttc gaa 451Ile Ser Asn Glu Leu Phe Glu Asp Ile Tyr Ser Phe Thr Asp Phe Glu

105 110 115tct gac atc aat gaa tgc att cga aac ccg ctc cca att ttg gaa ggt 499Ser Asp Ile Asn Glu Cys Ile Arg Asn Pro Leu Pro Ile Leu Glu Gly

120 125 130atc ggt ttt aac atc gcc aaa cat cat ctg agt tagcgatatt tcagcaaacc 552Ile Gly Phe Asn Ile Ala Lys His His Leu Ser

135140 gat 555<210>1136<211>144<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1136Val Phe Glu Gln Ala Leu Gly Leu Thr Thr Leu Ala Gln Thr Ala Gly 151015 Ala Gly Ala Ala Gly Gly Leu Gly Phe Met Ala Met Ala Leu Leu Ser

20 25 30Ala Gly Met Arg Ser Gly Val Asp Met Ile Leu Asn Glu Thr Gly Gly

35 40 45Glu Lys Met Leu Ala Gln Ala Asp Leu Val Ile Thr Gly Glu Gly Arg

50 55 60Ile Asp Ala Gln Thr Leu Ser Gly Lys Ala Pro Thr Gly Ile Ala Lys 65 70 75 80Arg Ala Arg Ala Lys Gly Ile Pro Val Leu Ala Val Cys Gly Gln Ser

85 90 95Leu Leu Gly Pro Ala Ile Ser Asn Glu Leu Phe Glu Asp Ile Tyr Ser

100 105 110Phe Thr Asp Phe Glu Ser Asp Ile Asn Glu Cys Ile Arg Asn Pro Leu

115 120 125Pro Ile Leu Glu Gly Ile Gly Phe Asn Ile Ala Lys His His Leu Ser

130135140<210>1137<211>898<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (898)<223>RXC02207<400>1137gaatcggtga ctttgccaac accaatcaca caagcccttg atgatgtctc cctgtgactt 60ggtccaatta cattcactgg taatctgaaa ccttgtgaat atg cgc cgt cga tcc 115

Met Arg Arg Arg Ser

1 5cgt gtg tcc cgt ttg ctt ccc gcc aca gct ttg ctg gcc tca act gca 163Arg Val Ser Arg Leu Leu Pro Ala Thr Ala Leu Leu Ala Ser Thr Ala

10 15 20ctt ctt tta agt gca tgt acg caa ggg gta acg gac tcc ccg gat atg 211Leu Leu Leu Ser Ala Cys Thr Gln Gly Val Thr Asp Ser Pro Asp Met

25 30 35ggc aag gca act ccc gct gtc tcc ccc gca gca agc aac ccg gat ggc 259Gly Lys Ala Thr Pro Ala Val Ser Pro Ala Ala Ser Asn Pro Asp Gly

40 45 50caa gta att gag ttc ggc aac atc act gac atg gaa gtc act gat ggt 307Gln Val Ile Glu Phe Gly Asn Ile Thr Asp Met Glu Val Thr Asp Gly

55 60 65gac atc ctc ggt gta cgc acc gaa gac gca ctc gct att ggt aca gtc 355Asp Ile Leu Gly Val Arg Thr Glu Asp Ala Leu Ala Ile Gly Thr Val 70 75 80 85tcc gac ttc gaa gcg ggt agc cag gtg gaa ctg gac gtc gat aag caa 403Ser Asp Phe Glu Ala Gly Ser Gln Val Glu Leu Asp Val Asp Lys Gln

90 95 100tgc ggc gac ctg acc gca acc ggc ggc act ttc gtg ctc ccc tgc gcc 451Cys Gly Asp Leu Thr Ala Thr Gly Gly Thr Phe Val Leu Pro Cys Ala

105 110 115gat ggc gtt tat ttg att gat gcc aag gac ccg gat ctg gat gag ttg 499Asp Gly Val Tyr Leu Ile Asp Ala Lys Asp Pro Asp Leu Asp Glu Leu

120 125 130cgt gca act gac aag cca gtc acg gtg gca gcc ttg acc agc gat gat 547Arg Ala Thr Asp Lys Pro Val Thr Val Ala Ala Leu Thr Ser Asp Asp

135 140 145cag ctt ctg gtg ggc aat ggt gaa gat gaa gaa ctc acc atc tac cgc 595Gln Leu Leu Val Gly Asn Gly Glu Asp Glu Glu Leu Thr Ile Tyr Arg150 155 160 165gag ggc gaa gag cca gaa acc ttc acc gtc gcg ggt ccc aat acc cag 643Glu Gly Glu Glu Pro Glu Thr Phe Thr Val Ala Gly Pro Asn Thr Gln

170 175 180ctc atc gcc gtt cct gtc att gat cgc cac gac gcc gtt gtg cgc acc 691Leu Ile Ala Val Pro Val Ile Asp Arg His Asp Ala Val Val Arg Thr

185 190 195tgg aac gaa aac acc acg att caa gat gtg gac tac ccc aac gac cgt 739Trp Asn Glu Asn Thr Thr Ile Gln Asp Val Asp Tyr Pro Asn Asp Arg

200 205 210gaa ggc gcg acc ctt cgc gtg gga ctc ggc gtt ggt caa atg gct ggt 787Glu Gly Ala Thr Leu Arg Val Gly Leu Gly Val Gly Gln Met Ala Gly

215 220 225ggc gaa gac ggc ctg ctg gtg gtc tct gat gaa atg ggt ggc caa att 835Gly Glu Asp Gly Leu Leu Val Val Ser Asp Glu Met Gly Gly Gln Ile230 235240 245gcc atc tac aac gct gat gat gtc atc cga ctt caa aat gac cgc ccc 883Ala Ile Tyr Asn Ala Asp Asp Val Ile Arg Leu Gln Asn Asp Arg Pro

250 255 260cac cga cga gga acc 898His Arg Arg Gly Thr

265<210>1138<211>266<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1138Met Arg Arg Arg Ser Arg Val Ser Arg Leu Leu Pro Ala Thr Ala Leu 151015 Leu Ala Ser Thr Ala Leu Leu Leu Ser Ala Cys Thr Gln Gly Val Thr

20 25 30Asp Ser Pro Asp Met Gly Lys Ala Thr Pro Ala Val Ser Pro Ala Ala

35 40 45Ser Asn Pro Asp Gly Gln Val Ile Glu Phe Gly Asn Ile Thr Asp Met

50 55 60Glu Val Thr Asp Gly Asp Ile Leu Gly Val Arg Thr Glu Asp Ala Leu 65 70 75 80Ala Ile Gly Thr Val Ser Asp Phe Glu Ala Gly Ser Gln Val Glu Leu

85 90 95Asp Val Asp Lys Gln Cys Gly Asp Leu Thr Ala Thr Gly Gly Thr Phe

100 105 110Val Leu Pro Cys Ala Asp Gly Val Tyr Leu Ile Asp Ala Lys Asp Pro

115 120 125Asp Leu Asp Glu Leu Arg Ala Thr Asp Lys Pro Val Thr Val Ala Ala

130 135 140Leu Thr Ser Asp Asp Gln Leu Leu Val Gly Asn Gly Glu Asp Glu Glu145 150 155 160Leu Thr Ile Tyr Arg Glu Gly Glu Glu Pro Glu Thr Phe Thr Val Ala

165 170175Gly Pro Asn Thr Gln Leu Ile Ala Val Pro Val Ile Asp Arg His Asp

180 185 190Ala Val Val Arg Thr Trp Asn Glu Asn Thr Thr Ile Gln Asp Val Asp

195 200 205Tyr Pro Asn Asp Arg Glu Gly Ala Thr Leu Arg Val Gly Leu Gly Val

210 215 220Gly Gln Met Ala Gly Gly Glu Asp Gly Leu Leu Val Val Ser Asp Glu225 230 235 240Met Gly Gly Gln Ile Ala Ile Tyr Asn Ala Asp Asp Val Ile Arg Leu

245 250 255Gln Asn Asp Arg Pro His Arg Arg Gly Thr

260265<210>1139<211>891<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<868><223>RXA00347<400>1139tcggccagca atccgcttgg tgtcctggat cgcgccgaca tcttaaggtg ccagggcttt 60aaagtgccag gggttctgtg ggatccgtac actggttccc atg act ttg act att 115

Met Thr Leu Thr Ile

1 5gag gaa atc gcc aag acc aaa aag ctt ttg gtt gtg tcc gat ttt gat 163Glu Glu Ile Ala Lys Thr Lys Lys Leu Leu Val Val Ser Asp Phe Asp

10 15 20gga acc atc gca gga ttt agc aag gac gct tac aac gtt cct atc aac 211Gly Thr Ile Ala Gly Phe Ser Lys Asp Ala Tyr Asn Val Pro Ile Asn

25 30 35cag aaa tcc ctc aag gcg gta aaa gac ctc tcc caa caa gca gac act 259Gln Lys Ser Leu Lys Ala Val Lys Asp Leu Ser Gln Gln Ala Asp Thr

40 45 50gat gtt gtc att ttg tcg gga cgt cac ctg gag gga ttg aag acg gtt 307Asp Val Val Ile Leu Ser Gly Arg His Leu Glu Gly Leu Lys Thr Val

55 60 65ctt gat ctt ggt cag tac gac atc acc atg gtg ggt tca cac ggt tct 355Leu Asp Leu Gly Gln Tyr Asp Ile Thr Met Val Gly Ser His Gly Ser 70 75 80 85gag gat tcc tcc cgc ccg cgt acc ctc act cct gaa gag gta gct cgc 403Glu Asp Ser Ser Arg Pro Arg Thr Leu Thr Pro Glu Glu Val Ala Arg

90 95 100ctc gcc aag att gaa gca gat ctg gaa aag atc gtc gac ggc atc gaa 451Leu Ala Lys Ile Glu Ala Asp Leu Glu Lys Ile Val Asp Gly Ile Glu

105 110 115ggc gca ttc gtg gag atc aag cct ttc cac cgc gtg ctg cac ttc atc 499Gly Ala Phe Val Glu Ile Lys Pro Phe His Arg Val Leu His Phe Ile

120 125 130cgt gtt tcc gac aag gac aaa gtc caa gga atc ctc gcc caa gca gca 547Arg Val Ser Asp Lys Asp Lys Val Gln Gly Ile Leu Ala Gln Ala Ala

135 140 145cac gta gac tct tcc ggc ctg aag gtt act aac ggc aag agc atc atc 595His Val Asp Ser Ser Gly Leu Lys Val Thr Asn Gly Lys Ser Ile Ile150 155 160 165gaa tac tcc atc agc tcc acc acc aag ggc acc tgg ctg aag gaa tac 643Glu Tyr Ser Ile Ser Ser Thr Thr Lys Gly Thr Trp Leu Lys Glu Tyr

170 175 180gtt gac cgc acc gag ccc act ggt gtg att ttc ctc ggc gat gac acc 691Val Asp Arg Thr Glu Pro Thr Gly Val Ile Phe Leu Gly Asp Asp Thr

185 190 195acc gat gag cac ggt ttc aaa gct tta gaa aac gat gat cgt gcc cta 739Thr Asp Glu His Gly Phe LysAla Leu Glu Asn Asp Asp Arg Ala Leu

200 205 210acc gtc aag gtt ggc gaa gga gac act gca gcc aaa acc cgc gtc gac 787Thr Val Lys Val Gly Glu Gly Asp Thr Ala Ala Lys Thr Arg Val Asp

215 220 225gat gtt gat aat gtg gga att ttc cta gag aaa ctc gcc tac cac cgc 835Asp Val Asp Asn Val Gly Ile Phe Leu Glu Lys Leu Ala Tyr His Arg230 235 240 245atg cag tat gcg gaa agc gtg cga ttg ggg att taagagagcc taaacgcacg 888Met Gln Tyr Ala Glu Ser Val Arg Leu Gly Ile

250255 aaa 891<210>1140<211>256<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1140Met Thr Leu Thr Ile Glu Glu Ile Ala Lys Thr Lys Lys Leu Leu Val 151015 Val Ser Asp Phe Asp Gly Thr Ile Ala Gly Phe Ser Lys Asp Ala Tyr

20 25 30Asn Val Pro Ile Asn Gln Lys Ser Leu Lys Ala Val Lys Asp Leu Ser

35 40 45Gln Gln Ala Asp Thr Asp Val Val Ile Leu Ser Gly Arg His Leu Glu

50 55 60Gly Leu Lys Thr Val Leu Asp Leu Gly Gln Tyr Asp Ile Thr Met Val 65 70 75 80Gly Ser His Gly Ser Glu Asp Ser Ser Arg Pro Arg Thr Leu Thr Pro

85 90 95Glu Glu Val Ala Arg Leu Ala Lys Ile Glu Ala Asp Leu Glu Lys Ile

100 105 110Val Asp Gly Ile Glu Gly Ala Phe Val Glu Ile Lys Pro Phe His Arg

115 120 125Val Leu His Phe Ile Arg Val Ser Asp Lys Asp Lys Val Gln Gly Ile

130135 140Leu Ala Gln Ala Ala His Val Asp Ser Ser Gly Leu Lys Val Thr Asn145 150 155 160Gly Lys Ser Ile Ile Glu Tyr Ser Ile Ser Ser Thr Thr Lys Gly Thr

165 170 175Trp Leu Lys Glu Tyr Val Asp Arg Thr Glu Pro Thr Gly Val Ile Phe

180 185 190Leu Gly Asp Asp Thr Thr Asp Glu His Gly Phe Lys Ala Leu Glu Asn

195 200 205Asp Asp Arg Ala Leu Thr Val Lys Val Gly Glu Gly Asp Thr Ala Ala

210 215 220Lys Thr Arg Val Asp Asp Val Asp Asn Val Gly Ile Phe Leu Glu Lys225 230 235 240Leu Ala Tyr His Arg Met Gln Tyr Ala Glu Ser Val Arg Leu Gly Ile

245250255<210>1141<211>2556<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (2533)<223>RXN01239<400>1141gcacttgctg cgtaaatctt tttcccacgc cgggaatgcg tgaacactaa gatcgaggac 60gtaccgcacg attttgccta acttttaagg gtgtttcatc atg gca cgt cca att 115

Met Ala Arg Pro Ile

1 5tcc gca acg tac agg ctt caa atg cga gga cct caa gca gat agc gcc 163Ser Ala Thr Tyr Arg Leu Gln Met Arg Gly Pro Gln Ala Asp Ser Ala

10 15 20ggg cgt tca ttt ggt ttt gcg cag gcc aaa gcc cag ctt ccc tat ctg 211Gly Arg Ser Phe Gly Phe Ala Gln Ala Lys Ala Gln Leu Pro Tyr Leu

25 30 35aag aag cta ggc atc agc cac ctg tac ctc tcc cct att ttt acg gcc 259Lys Lys Leu Gly Ile Ser His Leu Tyr Leu Ser Pro Ile Phe Thr Ala

40 45 50atg cca gat tcc aat cat ggc tac gat gtc att gat ccc acc acc atc 307Met Pro Asp Ser Asn His Gly Tyr Asp Val Ile Asp Pro Thr Thr Ile

55 60 65aat gaa gag ctc ggt ggc atg gag ggt ctt cga gat ctt gcc gca gct 355Asn Glu Glu Leu Gly Gly Met Glu Gly Leu Arg Asp Leu Ala Ala Ala70 75 80 85aca cac gag ttg ggc atg ggc atc atc att gat att gtt ccc aac cat 403Thr His Glu Leu Gly Met Gly Ile Ile Ile Asp Ile Val Pro Asn His

90 95 100tta ggt gtt gcc gtt cca cat ttg aat cct tgg tgg tgg gat gtt cta 451Leu Gly Val Ala Val Pro His Leu Asn Pro Trp Trp Trp Asp Val Leu

105 110 115aaa aac ggc aaa gat tcc gct ttt gag ttc tat ttc gat att gac tgg 499Lys Asn Gly Lys Asp Ser Ala Phe Glu Phe Tyr Phe Asp Ile Asp Trp

120 125 130cac gaa gac aac ggt tct ggt ggc aag ctg ggc atg ccg att ctg ggt 547His Glu Asp Asn Gly Ser Gly Gly Lys Leu Gly Met Pro Ile Leu Gly

135 140 145gct gaa ggc gat gaa gac aag ctg gaa ttc gcg gag ctt gat gga gag 595Ala Glu Gly Asp Glu Asp Lys Leu Glu Phe Ala Glu Leu Asp Gly Glu150 155 160 165aaa gtg ctc aaa tat ttt gac cac ctc ttc cca atc gcg cct ggt acc 643Lys Val Leu Lys Tyr Phe Asp His Leu Phe Pro Ile Ala Pro Gly Thr

170 175 180gaa gaa ggg aca ccg caa gaa gtc tac aag cgc cag cat tac cgc ctg 691Glu Glu Gly Thr Pro Gln Glu Val Tyr Lys Arg Gln His Tyr Arg Leu

185 190 195cag ttc tgg cgc gat ggc gtg atc aac ttc cgt cgc ttc ttt tcc gtg 739Gln Phe Trp Arg Asp Gly Val Ile Asn Phe Arg Arg Phe Phe Ser Val

200 205 210aat acg ttg gct ggc atc agg caa gaa gat ccc tta gtg ttt gaa cat 787Asn Thr Leu Ala Gly Ile Arg Gln Glu Asp Pro Leu Val Phe Glu His

215 220 225act cat cgt ctg ctg cgc gaa ttg gtg gcg gaa gac ctc att gac ggc 835Thr His Arg Leu Leu Arg Glu Leu Val Ala Glu Asp Leu Ile Asp Gly230 235 240 245gtg cgc gtc gat cac ccc gac ggg ctt tcc gat cct ttt gga tat ctg 883Val Arg Val Asp His Pro Asp Gly Leu Ser Asp Pro Phe Gly Tyr Leu

250 255 260cac aga ctc cgc gac ctc att gga cct gac cgc tgg ctg atc atc gaa 931His Arg Leu Arg Asp Leu Ile Gly Pro Asp Arg Trp Leu Ile Ile Glu

265 270 275aag atc ttg agc gtt gat gaa cca ctc gat ccc cgc ctg gcc gtt gat 979Lys Ile Leu Ser Val Asp Glu Pro Leu Asp Pro Arg Leu Ala Val Asp

280 285 290ggc acc act ggc tac gac gcc ctc cgt gaa ctc gac ggc gtg ttt atc 1027Gly Thr Thr Gly Tyr Asp Ala Leu Arg Glu Leu Asp Gly Val Phe Ile

295 300 305tcc cga gaa tct gag gac aaa ttc tcc atg ctg gcg ctg acc cac agt 1075Ser Arg Glu Ser Glu Asp Lys Phe Ser Met Leu Ala Leu Thr His Ser310 315 320 325gga tcc acc tgg gat gaa cgc gcc ctc aaa tcc acg gag gaa agc ctc 1123Gly Ser Thr Trp Asp Glu Arg Ala Leu Lys Ser Thr Glu Glu Ser Leu

330 335 340aaa cga gtcgtc gcc caa caa gaa ctc gca gcc gaa atc tta agg ctc 1171Lys Arg Val Val Ala Gln Gln Glu Leu Ala Ala Glu Ile Leu Arg Leu

345 350 355gcc cgc gcc atg cgc cgc gat aac ttc tcc acc gca ggc acc aac gtc 1219Ala Arg Ala Met Arg Arg Asp Asn Phe Ser Thr Ala Gly Thr Asn Val

360 365 370acc gaa gac aaa ctt agc gaa acc atc atc gaa tta gtc gcc gcc atg 1267Thr Glu Asp Lys Leu Ser Glu Thr Ile Ile Glu Leu Val Ala Ala Met

375 380 385ccc gtc tac cgc gcc gac tac atc tcc ctc tca cgc acc acc gcc acc 1315Pro Val Tyr Arg Ala Asp Tyr Ile Ser Leu Ser Arg Thr Thr Ala Thr390 395 400 405gtc atc gcg gag atg tcc aaa cgc ttc ccc tcc cgg cgt gac gca ctc 1363Val Ile Ala Glu Met Ser Lys Arg Phe Pro Ser Arg Arg Asp Ala Leu

410 415 420gac ctc atc gcg gcc gcc cta ctt ggc aat ggc gag gcc aaa atc cgc 1411Asp Leu Ile Ala Ala Ala Leu Leu Gly Asn Gly Glu Ala Lys Ile Arg

425 430 435ttc gct caa gtc tgc ggc gcc gtc atg gct aaa ggt gtg gaa gac acc 1459Phe Ala Gln Val Cys Gly Ala Val Met Ala Lys Gly Val Glu Asp Thr

440 445 450acc ttc tac cgc gca tct agg ctc gtt gca ttg caa gaa gtc ggt ggc 1507Thr Phe Tyr Arg Ala Ser Arg Leu Val Ala Leu Gln Glu Val Gly Gly

455 460 465gcg ccg ggg aga ttc ggc gtc tcc gct gca gaa ttc cac ttg ctg cag 1555Ala Pro Gly Arg Phe Gly Val Ser Ala Ala Glu Phe His Leu Leu Gln470 475 480 485gaa gaa cgc agc ctg ctg tgg cca cgc acc atg acc acc ttg tcc acg 1603Glu Glu Arg Ser Leu Leu Trp Pro Arg Thr Met Thr Thr Leu Ser Thr

490 495 500cat gac acc aaa cgt ggc gaa gat acc cgc gcc cgc atc atc tcc ctg 1651His Asp Thr Lys Arg Gly Glu Asp Thr Arg Ala Arg Ile Ile Ser Leu

505 510 515tct gaa gtc ccc gat atg tac tcc gag ctg gtc aat cgt gtt ttc gcg 1699Ser Glu Val Pro Asp Met Tyr Ser Glu Leu Val Asn Arg Val Phe Ala

520 525 530gtg ctc ccc gcg cca gac ggc gca acg ggc agt ttc ctc cta caa aac 1747Val Leu Pro Ala Pro Asp Gly Ala Thr Gly Ser Phe Leu Leu Gln Asn

535 540 545ctg ctg ggc gta tgg ccc gcc gac ggc gtg atc acc gat gcg ctg cgc 1795Leu Leu Gly Val Trp Pro Ala Asp Gly Val Ile Thr Asp Ala Leu Arg550 555 560 565gat cga ttc agg gaa tac gcc cta aaa gct atc cgc gaa gca tcc aca 1843Asp Arg Phe Arg Glu Tyr Ala Leu Lys Ala Ile Arg Glu Ala Ser Thr

570 575 580aaa acc acg tgg gtg gac ccc aac gag tcc ttc gag gct gcg gtc tgc 1891Lys Thr Thr Trp Val Asp Pro Asn Glu Ser Phe Glu Ala Ala Val Cys

585 590 595gat tgg gtg gaa gcg ctt ttc gac gga ccc tcc acc tca cta atc acc 1939Asp Trp Val Glu Ala Leu Phe Asp Gly Pro Ser Thr Ser Leu Ile Thr

600 605 610gaa ttt gtc tcc cac atc aac cgt ggc tct gtg caa atc tcc tta ggc 1987Glu Phe Val Ser His Ile Asn Arg Gly Ser Val Gln Ile Ser Leu Gly

615 620 625agg aaa ctg ctg caa atg gtg ggc gct gga atc ccc gac act tac caa 2035Arg Lys Leu Leu Gln Met Val Gly Ala Gly Ile Pro Asp Thr Tyr Gln630 635640 645gga act gag ttt tta gaa gac tcc ctg gta gat ccc gat aac cga cgc 2083Gly Thr Glu Phe Leu Glu Asp Ser Leu Val Asp Pro Asp Asn Arg Arg

650 655 660ttt gtt gat tac acc gcc aga gaa caa gtc ctg gag cgc ctg caa acc 2131Phe Val Asp Tyr Thr Ala Arg Glu Gln Val Leu Glu Arg Leu Gln Thr

665 670 675tgg gct tgg acg cag gtt aat tcg gta gaa gac ttg gtg gat aac gcc 2179Trp Ala Trp Thr Gln Val Asn Ser Val Glu Asp Leu Val Asp Asn Ala

680 685 690gac atc gcc aaa atg gcc gtg gtc cat aaa tcc ctc gag ttg cgt gct 2227Asp Ile Ala Lys Met Ala Val Val His Lys Ser Leu Glu Leu Arg Ala

695 700 705gaa ttt cgt gca agc ttt gtt ggt gga gat cat cag gca gta ttt ggc 2275Glu Phe Arg Ala Ser Phe Val Gly Gly Asp His Gln Ala Val Phe Gly710 715 720 725gaa ggt cgc gca gaa tcc cac atc atg ggc atc gcc cgc ggt aca gac 2323Glu Gly Arg Ala Glu Ser His Ile Met Gly Ile Ala Arg Gly Thr Asp

730 735 740cga aac cac ctc aac atc att gct ctt gct acc cgt cga cca ctg atc 2371Arg Asn His Leu Asn Ile Ile Ala Leu Ala Thr Arg Arg Pro Leu Ile

745 750 755ttg gaa gac cgt ggc gga tgg tat gac acc acc gtc acg ctt cct ggt 2419Leu Glu Asp Arg Gly Gly Trp Tyr Asp Thr Thr Val Thr Leu Pro Gly

760 765 770gga caa tgg gaa gac agg ctc acc ggg caa cgc ttc agt ggt gtt gtc 2467Gly Gln Trp Glu Asp Arg Leu Thr Gly Gln Arg Phe Ser Gly Val Val

775 780 785cca gcc acc gat ttgttc tca cat cta ccc gta tct ttg ttg gtt tta 2515Pro Ala Thr Asp Leu Phe Ser His Leu Pro Val Ser Leu Leu Val Leu790 795 800 805gta ccc gat agt gag ttt tgatccctgc acaggaaagt tag 2556Val Pro Asp Ser Glu Phe

810<210>1142<211>811<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1142Met Ala Arg Pro Ile Ser Ala Thr Tyr Arg Leu Gln Met Arg Gly Pro 151015 Gln Ala Asp Ser Ala Gly Arg Ser Phe Gly Phe Ala Gln Ala Lys Ala

20 25 30Gln Leu Pro Tyr Leu Lys Lys Leu Gly Ile Ser His Leu Tyr Leu Ser

35 40 45Pro Ile Phe Thr Ala Met Pro Asp Ser Asn His Gly Tyr Asp Val Ile

50 55 60Asp Pro Thr Thr Ile Asn Glu Glu Leu Gly Gly Met Glu Gly Leu Arg 65 70 75 80Asp Leu Ala Ala Ala Thr His Glu Leu Gly Met Gly Ile Ile Ile Asp

85 90 95Ile Val Pro Asn His Leu Gly Val Ala Val Pro His Leu Asn Pro Trp

100 105 110Trp Trp Asp Val Leu Lys Asn Gly Lys Asp Ser Ala Phe Glu Phe Tyr

115 120 125Phe Asp Ile Asp Trp His Glu Asp Asn Gly Ser Gly Gly Lys Leu Gly

130 135 140Met Pro Ile Leu Gly Ala Glu Gly Asp Glu Asp Lys Leu Glu Phe Ala145 150 155 160Glu Leu Asp Gly Glu Lys Val Leu Lys Tyr Phe Asp His Leu Phe Pro

165 170 175Ile Ala Pro Gly Thr Glu Glu Gly Thr Pro Gln Glu Val Tyr Lys Arg

180 185 190Gln His Tyr Arg Leu Gln Phe Trp Arg Asp Gly Val Ile Asn Phe Arg

195 200 205Arg Phe Phe Ser Val Asn Thr Leu Ala Gly Ile Arg Gln Glu Asp Pro

210 215 220Leu Val Phe Glu His Thr His Arg Leu Leu Arg Glu Leu Val Ala Glu225 230 235 240Asp Leu Ile Asp Gly Val Arg Val Asp His Pro Asp Gly Leu Ser Asp

245 250 255Pro Phe Gly Tyr Leu His Arg Leu Arg Asp Leu Ile Gly Pro Asp Arg

260 265 270Trp Leu Ile Ile Glu Lys Ile Leu Ser Val Asp Glu Pro Leu Asp Pro

275 280 285Arg Leu Ala Val Asp Gly Thr Thr Gly Tyr Asp Ala Leu Arg Glu Leu

290 295 300Asp Gly Val Phe Ile Ser Arg Glu Ser Glu Asp Lys Phe Ser Met Leu305 310 315 320Ala Leu Thr His Ser Gly Ser Thr Trp Asp Glu Arg Ala Leu Lys Ser

325 330 335Thr Glu Glu Ser Leu Lys Arg Val Val Ala Gln Gln Glu Leu Ala Ala

340 345 350Glu Ile Leu Arg Leu Ala Arg Ala Met Arg Arg Asp Asn Phe Ser Thr

355 360 365Ala Gly Thr Asn Val Thr Glu Asp Lys Leu Ser Glu Thr Ile Ile Glu

370 375 380Leu Val Ala Ala Met Pro Val Tyr Arg Ala Asp Tyr Ile Ser Leu Ser385 390 395 400Arg Thr Thr Ala Thr Val Ile Ala Glu Met Ser Lys Arg Phe Pro Ser

405 410 415Arg Arg Asp Ala Leu Asp Leu Ile Ala Ala Ala Leu Leu Gly Asn Gly

420 425 430Glu Ala Lys Ile Arg Phe Ala Gln Val Cys Gly Ala Val Met Ala Lys

435 440 445Gly Val Glu Asp Thr Thr Phe Tyr Arg Ala Ser Arg Leu Val Ala Leu

450 455 460Gln Glu Val Gly Gly Ala Pro Gly Arg Phe Gly Val Ser Ala Ala Glu465 470 475 480Phe His Leu Leu Gln Glu Glu Arg Ser Leu Leu Trp Pro Arg Thr Met

485 490 495Thr Thr Leu Ser Thr His Asp Thr Lys Arg Gly Glu Asp Thr Arg Ala

500 505 510Arg Ile Ile Ser Leu Ser Glu Val Pro Asp Met Tyr Ser Glu Leu Val

515 520 525Asn Arg Val Phe Ala Val Leu Pro Ala Pro Asp Gly Ala Thr Gly Ser

530 535 540Phe Leu Leu Gln Asn Leu Leu Gly Val Trp Pro Ala Asp Gly Val Ile545 550 555 560Thr Asp Ala Leu Arg Asp Arg Phe Arg Glu Tyr Ala Leu Lys Ala Ile

565 570 575Arg Glu Ala Ser Thr Lys Thr Thr Trp Val Asp Pro Asn Glu Ser Phe

580 585 590Glu Ala Ala Val Cys Asp Trp Val Glu Ala Leu Phe Asp Gly Pro Ser

595 600 605Thr Ser Leu Ile Thr Glu Phe Val Ser His Ile Asn Arg Gly Ser Val

610 615 620Gln Ile Ser Leu Gly ArgLys Leu Leu Gln Met Val Gly Ala Gly Ile625 630 635 640Pro Asp Thr Tyr Gln Gly Thr Glu Phe Leu Glu Asp Ser Leu Val Asp

645 650 655Pro Asp Asn Arg Arg Phe Val Asp Tyr Thr Ala Arg Glu Gln Val Leu

660 665 670Glu Arg Leu Gln Thr Trp Ala Trp Thr Gln Val Asn Ser Val Glu Asp

675 680 685Leu Val Asp Asn Ala Asp Ile Ala Lys Met Ala Val Val His Lys Ser

690 695 700Leu Glu Leu Arg Ala Glu Phe Arg Ala Ser Phe Val Gly Gly Asp His705 710 715 720Gln Ala Val Phe Gly Glu Gly Arg Ala Glu Ser His Ile Met Gly Ile

725 730 735Ala Arg Gly Thr Asp Arg Asn His Leu Asn Ile Ile Ala Leu Ala Thr

740 745 750Arg Arg Pro Leu Ile Leu Glu Asp Arg Gly Gly Trp Tyr Asp Thr Thr

755 760 765Val Thr Leu Pro Gly Gly Gln Trp Glu Asp Arg Leu Thr Gly Gln Arg

770 775 780Phe Ser Gly Val Val Pro Ala Thr Asp Leu Phe Ser His Leu Pro Val785 790 795 800Ser Leu Leu Val Leu Val Pro Asp Ser Glu Phe

805810<210>1143<211>2556<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (2533)<223>FRXA01239<400>1143gcacttgctg cgtaaatctt tttcccacgc cgggaatgcg tgaacactaa gatcgaggac 60gtaccgcacg attttgccta acttttaagg gtgtttcatc atg gca cgt cca att 115

Met Ala Arg Pro Ile

1 5tcc gca acg tac agg ctt caa atg cga gga cct caa gca gat agc gcc 163Ser Ala Thr Tyr Arg Leu Gln Met Arg Gly Pro Gln Ala Asp Ser Ala

10 15 20ggg cgt tca ttt ggt ttt gcg cag gcc aaa gcc cag ctt ccc tat ctg 211Gly Arg Ser Phe Gly Phe Ala Gln Ala Lys Ala Gln Leu Pro Tyr Leu

25 30 35aag aag cta ggc atc agc cac ctg tac ctc tcc cct att ttt acg gcc 259Lys Lys Leu Gly Ile Ser His Leu Tyr Leu Ser Pro Ile Phe Thr Ala

40 45 50atg cca gat tcc aat cat ggc tac gat gtc att gat ccc acc acc atc 307Met Pro Asp Ser Asn His Gly Tyr Asp Val Ile Asp Pro Thr Thr Ile

55 60 65aat gaa gag ctc ggt ggc atg gag ggt ctt cga gat ctt gcc gca gct 355Asn Glu Glu Leu Gly Gly Met Glu Gly Leu Arg Asp Leu Ala Ala Ala 70 75 80 85aca cac gag ttg ggc atg ggc atc atc att gat att gtt ccc aac cat 403Thr His Glu Leu Gly Met Gly Ile Ile Ile Asp Ile Val Pro Asn His

90 95 100tta ggt gtt gcc gtt cca cat ttg aat cct tgg tgg tgg gat gtt cta 451Leu Gly Val Ala Val Pro His Leu Asn Pro Trp Trp Trp Asp Val Leu

105 110 115aaa aac ggc aaa gat tcc gct ttt gag ttc tat ttc gat att gac tgg 499Lys Asn Gly Lys Asp Ser Ala Phe Glu Phe Tyr Phe Asp Ile Asp Trp

120 125 130cac gaa gac aac ggt tct ggt ggc aag ctg ggc atg ccg att ctg ggt 547His Glu Asp Asn Gly Ser Gly Gly Lys Leu Gly Met Pro Ile Leu Gly

135 140 145gct gaa ggc gat gaa gac aag ctg gaa ttc gcg gag ctt gat gga gag 595Ala Glu Gly Asp Glu Asp Lys Leu Glu Phe Ala Glu Leu Asp Gly Glu150 155 160 165aaa gtg ctc aaa tat ttt gac cac ctc ttc cca atc gcg cct ggt acc 643Lys Val Leu Lys Tyr Phe Asp His Leu Phe Pro Ile Ala Pro Gly Thr

170 175 180gaa gaa ggg aca ccg caa gaa gtc tac aag cgc cag cat tac cgc ctg 691Glu Glu Gly Thr Pro Gln Glu Val Tyr Lys Arg Gln His Tyr Arg Leu

185 190 195cag ttc tgg cgc gat ggc gtg atc aac ttc cgt cgc ttc ttt tcc gtg 739Gln Phe Trp Arg Asp Gly Val Ile Asn Phe Arg Arg Phe Phe Ser Val

200 205 210aat acg ttg gct ggc atc agg caa gaa gat ccc tta gtg ttt gaa cat 787Asn Thr Leu Ala Gly Ile Arg Gln Glu Asp Pro Leu Val Phe Glu His

215 220 225act cat cgt ctg ctg cgc gaa ttg gtg gcg gaa gac ctc att gac ggc 835Thr His Arg Leu Leu Arg Glu Leu Val Ala Glu Asp Leu Ile Asp Gly230 235 240 245gtg cgc gtc gat cac ccc gac ggg ctt tcc gat cct ttt gga tat ctg 883Val Arg Val Asp His Pro Asp Gly Leu Ser Asp Pro Phe Gly Tyr Leu

250 255 260cac aga ctc cgc gac ctc att gga cct gac cgc tgg ctg atc atc gaa 931His Arg Leu Arg Asp Leu Ile Gly Pro Asp Arg Trp Leu Ile Ile Glu

265 270 275aag atc ttg agc gtt gat gaa cca ctc gat ccc cgc ctg gcc gtt gat 979Lys Ile Leu Ser Val Asp Glu Pro Leu Asp Pro Arg Leu Ala Val Asp

280 285 290ggc acc act ggc tac gac gcc ctc cgt gaa ctc gac ggc gtg ttt atc 1027Gly Thr Thr Gly Tyr Asp Ala Leu Arg Glu Leu Asp Gly Val Phe Ile

295 300 305tcc cga gaa tct gag gac aaa ttc tcc atg ctg gcg ctg acc cac agt 1075Ser Arg Glu Ser Glu Asp Lys Phe Ser Met Leu Ala Leu Thr His Ser310 315 320 325gga tcc acc tgg gat gaa cgc gcc ctc aaa tcc acg gag gaa agc ctc 1123Gly Ser Thr Trp Asp Glu Arg Ala Leu Lys Ser Thr Glu Glu Ser Leu

330 335 340aaa cga gtc gtc gcc caa caa gaa ctc gca gcc gaa atc tta agg ctc 1171Lys Arg Val Val Ala Gln Gln Glu Leu Ala Ala Glu Ile Leu Arg Leu

345 350 355gcc cgc gcc atg cgc cgc gat aac ttc tcc acc gca ggc acc aac gtc 1219Ala Arg Ala Met Arg Arg Asp Asn Phe Ser Thr Ala Gly Thr Asn Val

360 365 370acc gaa gac aaa ctt agc gaa acc atc atc gaa tta gtc gcc gcc atg 1267Thr Glu Asp Lys Leu Ser Glu Thr Ile Ile Glu Leu Val Ala Ala Met

375 380 385ccc gtc tac cgc gcc gac tac atc tcc ctc tca cgc acc acc gcc acc 1315Pro Val Tyr Arg Ala Asp Tyr Ile Ser Leu Ser Arg Thr Thr Ala Thr390 395 400 405gtc atc gcg gag atg tcc aaa cgc ttc ccc tcc cgg cgt gac gca ctc 1363Val Ile Ala Glu Met Ser Lys Arg Phe Pro Ser Arg Arg Asp Ala Leu

410 415 420gac ctc atc gcg gcc gcc cta ctt ggc aat ggc gag gcc aaa atc cgc 1411Asp Leu Ile Ala Ala Ala Leu Leu Gly Asn Gly Glu Ala Lys Ile Arg

425 430 435ttc gct caa gtc tgc ggc gcc gtc atg gct aaa ggt gtg gaa gac acc 1459Phe Ala Gln Val Cys Gly Ala Val Met Ala Lys Gly Val Glu AspThr

440 445 450acc ttc tac cgc gca tct agg ctc gtt gca ttg caa gaa gtc ggt ggc 1507Thr Phe Tyr Arg Ala Ser Arg Leu Val Ala Leu Gln Glu Val Gly Gly

455 460 465gcg ccg ggg aga ttc ggc gtc tcc gct gca gaa ttc cac ttg ctg cag 1555Ala Pro Gly Arg Phe Gly Val Ser Ala Ala Glu Phe His Leu Leu Gln470 475 480 485gaa gaa cgc agc ctg ctg tgg cca cgc acc atg acc acc ttg tcc acg 1603Glu Glu Arg Ser Leu Leu Trp Pro Arg Thr Met Thr Thr Leu Ser Thr

490 495 500cat gac acc aaa cgt ggc gaa gat acc cgc gcc cgc atc atc tcc ctg 1651His Asp Thr Lys Arg Gly Glu Asp Thr Arg Ala Arg Ile Ile Ser Leu

505 510 515tct gaa gtc ccc gat atg tac tcc gag ctg gtc aat cgt gtt ttc gcg 1699Ser Glu Val Pro Asp Met Tyr Ser Glu Leu Val Asn Arg Val Phe Ala

520 525 530gtg ctc ccc gcg cca gac ggc gca acg ggc agt ttc ctc cta caa aac 1747Val Leu Pro Ala Pro Asp Gly Ala Thr Gly Ser Phe Leu Leu Gln Asn

535 540 545ctg ctg ggc gta tgg ccc gcc gac ggc gtg atc acc gat gcg ctg cgc 1795Leu Leu Gly Val Trp Pro Ala Asp Gly Val Ile Thr Asp Ala Leu Arg550 555 560 565gat cga ttc agg gaa tac gcc cta aaa gct atc cgc gaa gca tcc aca 1843Asp Arg Phe Arg Glu Tyr Ala Leu Lys Ala Ile Arg Glu Ala Ser Thr

570 575 580aaa acc acg tgg gtg gac ccc aac gag tcc ttc gag gct gcg gtc tgc 1891Lys Thr Thr Trp Val Asp Pro Asn Glu Ser Phe Glu Ala Ala Val Cys

585 590 595gat tgg gtg gaa gcg ctt ttc gac gga ccc tcc acc tca cta atc acc 1939Asp Trp Val Glu Ala Leu Phe Asp Gly Pro Ser Thr Ser Leu Ile Thr

600 605 610gaa ttt gtc tcc cac atc aac cgt ggc tct gtg caa atc tcc tta ggc 1987Glu Phe Val Ser His Ile Asn Arg Gly Ser Val Gln Ile Ser Leu Gly

615 620 625agg aaa ctg ctg caa atg gtg ggc gct gga atc ccc gac act tac caa 2035Arg Lys Leu Leu Gln Met Val Gly Ala Gly Ile Pro Asp Thr Tyr Gln630 635 640 645gga act gag ttt tta gaa gac tcc ctg gta gat ccc gat aac cga cgc 2083Gly Thr Glu Phe Leu Glu Asp Ser Leu Val Asp Pro Asp Asn Arg Arg

650 655 660ttt gtt gat tac acc gcc aga gaa caa gtc ctg gag cgc ctg caa acc 2131Phe Val Asp Tyr Thr Ala Arg Glu Gln Val Leu Glu Arg Leu Gln Thr

665 670 675tgg gat tgg acg cag gtt aat tcg gta gaa gac ttg gtg gat aac gcc 2179Trp Asp Trp Thr Gln Val Asn Ser Val Glu Asp Leu Val Asp Asn Ala

680 685 690gac atc gcc aaa atg gcc gtg gtc cat aaa tcc ctc gag ttg cgt gct 2227Asp Ile Ala Lys Met Ala Val Val His Lys Ser Leu Glu Leu Arg Ala

695 700 705gaa ttt cgt gca agc ttt gtt ggt gga gat cat cag gca gta ttt ggc 2275Glu Phe Arg Ala Ser Phe Val Gly Gly Asp His Gln Ala Val Phe Gly710 715 720 725gaa ggt cgc gca gaa tcc cac atc atg ggc atc gcc cgc ggt aca gac 2323Glu Gly Arg Ala Glu Ser His Ile Met Gly Ile Ala Arg Gly Thr Asp

730 735 740cga aac cac ctc aac atc att gct ctt gct acc cgt cga cca ctg atc 2371Arg Asn His Leu Asn Ile Ile Ala Leu Ala Thr Arg Arg Pro Leu Ile

745 750 755ttg gaa gac cgt ggc gga tgg tat gac acc acc gtc acg ctt cct ggt 2419Leu Glu Asp Arg Gly Gly Trp Tyr Asp Thr Thr Val Thr Leu Pro Gly

760 765 770gga caa tgg gaa gac agg ctc acc ggg caa cgc ttc agt ggt gtt gtc 2467Gly Gln Trp Glu Asp Arg Leu Thr Gly Gln Arg Phe Ser Gly Val Val

775 780 785cca gcc acc gat ttg ttc tca cat cta ccc gta tct ttg ttg gtt tta 2515Pro Ala Thr Asp Leu Phe Ser His Leu Pro Val Ser Leu Leu Val Leu790 795 800 805gta ccc gat agt gag ttt tgatccctgc acaggaaagt tag 2556Val Pro Asp Ser Glu Phe

810<210>1144<211>811<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1144Met Ala Arg Pro Ile Ser Ala Thr Tyr Arg Leu Gln Met Arg Gly Pro 151015 Gln Ala Asp Ser Ala Gly Arg Ser Phe Gly Phe Ala Gln Ala Lys Ala

20 25 30Gln Leu Pro Tyr Leu Lys Lys Leu Gly Ile Ser His Leu Tyr Leu Ser

35 40 45Pro Ile Phe Thr Ala Met Pro Asp Ser Asn His Gly Tyr Asp Val Ile

50 55 60Asp Pro Thr Thr Ile Asn Glu Glu Leu Gly Gly Met Glu Gly Leu Arg 65 70 75 80Asp Leu Ala Ala Ala Thr His Glu Leu Gly Met Gly Ile Ile Ile Asp

85 90 95Ile Val Pro Asn His Leu Gly Val Ala Val Pro His Leu Asn Pro Trp

100 105 110Trp Trp Asp Val Leu Lys Asn Gly Lys Asp Ser Ala PheGlu Phe Tyr

115 120 125Phe Asp Ile Asp Trp His Glu Asp Asn Gly Ser Gly Gly Lys Leu Gly

130 135 140Met Pro Ile Leu Gly Ala Glu Gly Asp Glu Asp Lys Leu Glu Phe Ala145 150 155 160Glu Leu Asp Gly Glu Lys Val Leu Lys Tyr Phe Asp His Leu Phe Pro

165 170 175Ile Ala Pro Gly Thr Glu Glu Gly Thr Pro Gln Glu Val Tyr Lys Arg

180 185 190Gln His Tyr Arg Leu Gln Phe Trp Arg Asp Gly Val Ile Asn Phe Arg

195 200 205Arg Phe Phe Ser Val Asn Thr Leu Ala Gly Ile Arg Gln Glu Asp Pro

210 215 220Leu Val Phe Glu His Thr His Arg Leu Leu Arg Glu Leu Val Ala Glu225 230 235 240Asp Leu Ile Asp Gly Val Arg Val Asp His Pro Asp Gly Leu Ser Asp

245 250 255Pro Phe Gly Tyr Leu His Arg Leu Arg Asp Leu Ile Gly Pro Asp Arg

260 265 270Trp Leu Ile Ile Glu Lys Ile Leu Ser Val Asp Glu Pro Leu Asp Pro

275 280 285Arg Leu Ala Val Asp Gly Thr Thr Gly Tyr Asp Ala Leu Arg Glu Leu

290 295 300Asp Gly Val Phe Ile Ser Arg Glu Ser Glu Asp Lys Phe Ser Met Leu305 310 315 320Ala Leu Thr His Ser Gly Ser Thr Trp Asp Glu Arg Ala Leu Lys Ser

325 330 335Thr Glu Glu Ser Leu Lys Arg Val Val Ala Gln GlnGlu Leu Ala Ala

340 345 350Glu Ile Leu Arg Leu Ala Arg Ala Met Arg Arg Asp Asn Phe Ser Thr

355 360 365Ala Gly Thr Asn Val Thr Glu Asp Lys Leu Ser Glu Thr Ile Ile Glu

370 375 380Leu Val Ala Ala Met Pro Val Tyr Arg Ala Asp Tyr Ile Ser Leu Ser385 390 395 400Arg Thr Thr Ala Thr Val Ile Ala Glu Met Ser Lys Arg Phe Pro Ser

405 410 415Arg Arg Asp Ala Leu Asp Leu Ile Ala Ala Ala Leu Leu Gly Asn Gly

420 425 430Glu Ala Lys Ile Arg Phe Ala Gln Val Cys Gly Ala Val Met Ala Lys

435 440 445Gly Val Glu Asp Thr Thr Phe Tyr Arg Ala Ser Arg Leu Val Ala Leu

450 455 460Gln Glu Val Gly Gly Ala Pro Gly Arg Phe Gly Val Ser Ala Ala Glu465 470 475 480Phe His Leu Leu Gln Glu Glu Arg Ser Leu Leu Trp Pro Arg Thr Met

485 490 495Thr Thr Leu Ser Thr His Asp Thr Lys Arg Gly Glu Asp Thr Arg Ala

500 505 510Arg Ile Ile Ser Leu Ser Glu Val Pro Asp Met Tyr Ser Glu Leu Val

515 520 525Asn Arg Val Phe Ala Val Leu Pro Ala Pro Asp Gly Ala Thr Gly Ser

530 535 540Phe Leu Leu Gln Asn Leu Leu Gly Val Trp Pro Ala Asp Gly Val Ile545 550 555 560Thr Asp Ala Leu Arg Asp Arg Phe Arg GluTyr Ala Leu Lys Ala Ile

565 570 575Arg Glu Ala Ser Thr Lys Thr Thr Trp Val Asp Pro Asn Glu Ser Phe

580 585 590Glu Ala Ala Val Cys Asp Trp Val Glu Ala Leu Phe Asp Gly Pro Ser

595 600 605Thr Ser Leu Ile Thr Glu Phe Val Ser His Ile Asn Arg Gly Ser Val

610 615 620Gln Ile Ser Leu Gly Arg Lys Leu Leu Gln Met Val Gly Ala Gly Ile625 630 635 640Pro Asp Thr Tyr Gln Gly Thr Glu Phe Leu Glu Asp Ser Leu Val Asp

645 650 655Pro Asp Asn Arg Arg Phe Val Asp Tyr Thr Ala Arg Glu Gln Val Leu

660 665 670Glu Arg Leu Gln Thr Trp Asp Trp Thr Gln Val Asn Ser Val Glu Asp

675 680 685Leu Val Asp Asn Ala Asp Ile Ala Lys Met Ala Val Val His Lys Ser

690 695 700Leu Glu Leu Arg Ala Glu Phe Arg Ala Ser Phe Val Gly Gly Asp His705 710 715 720Gln Ala Val Phe Gly Glu Gly Arg Ala Glu Ser His Ile Met Gly Ile

725 730 735Ala Arg Gly Thr Asp Arg Asn His Leu Asn Ile Ile Ala Leu Ala Thr

740 745 750Arg Arg Pro Leu Ile Leu Glu Asp Arg Gly Gly Trp Tyr Asp Thr Thr

755 760 765Val Thr Leu Pro Gly Gly Gln Trp Glu Asp Arg Leu Thr Gly Gln Arg

770 775 780Phe Ser Gly Val Val Pro Ala Thr Asp Leu Phe Ser His Leu Pro Val785 790 795 800Ser Leu Leu Val Leu Val Pro Asp Ser Glu Phe

805810<210>1145<211>1953<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1930)<223>RXA02645<400>1145gatacagctc cttgatggag tgaataaatt cgcgagcctg ctcctgatct tgcacacgcg 60tgatataggt cagaaatcgc gagcgcttga tctctagttc atg ctc aaa gac ttg 115

Met Leu Lys Asp Leu

1 5acc ggc ctg agg gag ttg gta ttg cgt gag atg tgc cat agc atc tca 163Thr Gly Leu Arg Glu Leu Val Leu Arg Glu Met Cys His Ser Ile Ser

10 15 20cat ctt agc tcg cca acc ggc agc att ttc act agc ctg gtg gcc atg 211His Leu Ser Ser Pro Thr Gly Ser Ile Phe Thr Ser Leu Val Ala Met

25 30 35ttg acc tcg caa agc ttt tca gtg tgg gct cca ctt ccc cac gat gta 259Leu Thr Ser Gln Ser Phe Ser Val Trp Ala Pro Leu Pro His Asp Val

40 45 50cat ctg atc ctc aac ggc gaa acc ctc ccc atg cac aaa acg gag ggc 307His Leu Ile Leu Asn Gly Glu Thr Leu Pro Met His Lys Thr Glu Gly

55 60 65agc tgg tgg cgc gcc gag atc gcg ccc aag gcc ggc gat cgt tac ggt 355Ser Trp Trp Arg Ala Glu Ile Ala Pro Lys Ala Gly Asp Arg Tyr Gly 70 75 80 85ttt tcg ctt ttc gac ggc tcc tcc tgg tca aaa acc ctc ccc gat ccc 403Phe Ser Leu Phe Asp Gly Ser Ser Trp Ser Lys Thr Leu Pro Asp Pro

90 95100cgc tcc aca tct caa cca gac ggg gtt cat ggt tta agt gaa gtc tcc 451Arg Ser Thr Ser Gln Pro Asp Gly Val His Gly Leu Ser Glu Val Ser

105 110 115gat gat tcc tat ctg tgg ggt gac cag cag tgg act ggc cga att ctc 499Asp Asp Ser Tyr Leu Trp Gly Asp Gln Gln Trp Thr Gly Arg Ile Leu

120 125 130cct ggc tcg gtg tta tat gag ctg cat gtg ggc acc ttt agt gaa gat 547Pro Gly Ser Val Leu Tyr Glu Leu His Val Gly Thr Phe Ser Glu Asp

135 140 145gga acg ttt gag gga gtc gtc gac aag ctt cct tat ctg cgc gac ctc 595Gly Thr Phe Glu Gly Val Val Asp Lys Leu Pro Tyr Leu Arg Asp Leu150 155 160 165ggc gtg acc gcc atc gaa ctt tta ccc gtg cag ccc ttt ggc ggc aac 643Gly Val Thr Ala Ile Glu Leu Leu Pro Val Gln Pro Phe Gly Gly Asn

170 175 180cgc aat tgg ggc tac gac ggg gtg ctg tgg cac gcc gtc cat gca ggc 691Arg Asn Trp Gly Tyr Asp Gly Val Leu Trp His Ala Val His Ala Gly

185 190 195tac ggc ggt ccg gcg ggc ttg aaa aag ctt atc gac gcc tcc cac cag 739Tyr Gly Gly Pro Ala Gly Leu Lys Lys Leu Ile Asp Ala Ser His Gln

200 205 210gcc ggc atc gcc gtc tac tta gac gtc gtg tac aac cac ttc ggc ccc 787Ala Gly Ile Ala Val Tyr Leu Asp Val Val Tyr Asn His Phe Gly Pro

215 220 225gac ggc aac tac aac ggg caa ttt ggc ccc tac acc tct ggc ggc agc 835Asp Gly Asn Tyr Asn Gly Gln Phe Gly Pro Tyr Thr Ser Gly Gly Ser230 235 240 245acc ggc tgg ggc gac gtg gtc aac atc aac ggc cat gat tca gat gaa 883Thr Gly Trp Gly Asp Val Val Asn Ile Asn Gly His Asp Ser Asp Glu

250 255 260gtc cgc aat tat att ctc gac gcc gca cgc cag tgg ttc gaa gat ttt 931Val Arg Asn Tyr Ile Leu Asp Ala Ala Arg Gln Trp Phe Glu Asp Phe

265 270 275cac gtt gat ggg ctc cgc ctc gat gcg gtg cat tct ctc gat gat cgc 979His Val Asp Gly Leu Arg Leu Asp Ala Val His Ser Leu Asp Asp Arg

280 285 290ggc gcc tat tcc cta ctt gcg cag ctg acc atg gtg gcc gag gat gtc 1027Gly Ala Tyr Ser Leu Leu Ala Gln Leu Thr Met Val Ala Glu Asp Val

295 300 305tcc gca caa aca ggc atc cca cgc tca ttg att gca gaa tct gaa ctc 1075Ser Ala Gln Thr Gly Ile Pro Arg Ser Leu Ile Ala Glu Ser Glu Leu310 315 320 325aat gac ccc aag ttc gtt acc tcc cgc gag gcc ggc ggt ttt ggc ctg 1123Asn Asp Pro Lys Phe Val Thr Ser Arg Glu Ala Gly Gly Phe Gly Leu

330 335 340gat gca cag tgg gtt gac gat atc cac cac gcc ctc cat gcc ctc gtt 1171Asp Ala Gln Trp Val Asp Asp Ile His His Ala Leu His Ala Leu Val

345 350 355tct ggc gaa cgc aat ggt tat tac agc gat ttc gga tct gtc gac aca 1219Ser Gly Glu Arg Asn Gly Tyr Tyr Ser Asp Phe Gly Ser Val Asp Thr

360 365 370tta gcc aaa acc ctg cgt gaa gta ttt gaa cac acc gga aac tac tcc 1267Leu Ala Lys Thr Leu Arg Glu Val Phe Glu His Thr Gly Asn Tyr Ser

375 380 385acg tac cgc gga cgc aac cac ggc cgc cct gtg cac ccc gat atc acc 1315Thr Tyr Arg Gly Arg Asn His Gly Arg Pro Val His Pro Asp Ile Thr390395 400 405cct gcc tcg cgc ttt gtc acc tac acc acc acc cat gat cag acc ggc 1363Pro Ala Ser Arg Phe Val Thr Tyr Thr Thr Thr His Asp Gln Thr Gly

410 415 420aac cgc gca atc ggc gac cgt cct tcc acg act ctc acc ccg gaa cag 1411Asn Arg Ala Ile Gly Asp Arg Pro Ser Thr Thr Leu Thr Pro Glu Gln

425 430 435cag gtg ttg aag gca gcc att atc tac agc tcg ccg tat acc ccg atg 1459Gln Val Leu Lys Ala Ala Ile Ile Tyr Ser Ser Pro Tyr Thr Pro Met

440 445 450ttg ttt atg ggt gaa gaa ttc gga gcc acc acc cca ttc gcc ttc ttt 1507Leu Phe Met Gly Glu Glu Phe Gly Ala Thr Thr Pro Phe Ala Phe Phe

455 460 465tgc tcc cac acc gac ccc gag ctc aac cgg cta acc tcc gag ggc cgc 1555Cys Ser His Thr Asp Pro Glu Leu Asn Arg Leu Thr Ser Glu Gly Arg470 475 480 485aaa cgg gaa ttc gca cgc ctt ggc tgg aac gcc gac gac atc ccc tcc 1603Lys Arg Glu Phe Ala Arg Leu Gly Trp Asn Ala Asp Asp Ile Pro Ser

490 495 500ccc gag ctg gaa tcc acc ttc acc tcc tcc aaa ctc gat tgg gag ttc 1651Pro Glu Leu Glu Ser Thr Phe Thr Ser Ser Lys Leu Asp Trp Glu Phe

505 510 515act gcg gag cag cgc cgc atc aac gac gct tac aag cag ctg ttg cac 1699Thr Ala Glu Gln Arg Arg Ile Asn Asp Ala Tyr Lys Gln Leu Leu His

520 525 530ctg cgg cac acc ttg ggc ttc tcc caa cca aac ttg ctc aca ctc gag 1747Leu Arg His Thr Leu Gly Phe Ser Gln Pro Asn Leu Leu Thr Leu Glu

535 540 545gtt gag cac ggc gag aac tgg cta tcg atg gcc aat ggt cgc ggc cga 1795Val Glu His Gly Glu Asn Trp Leu Ser Met Ala Asn Gly Arg Gly Arg550 555 560 565att ctg gcg aat ttc tcc gac gac acc atc acc gtc ccg ctt ggc ggc 1843Ile Leu Ala Asn Phe Ser Asp Asp Thr Ile Thr Val Pro Leu Gly Gly

570 575 580gag ctg att tac agc ttc act tcc ccc acc gtc acc gac acc tcc aca 1891Glu Leu Ile Tyr Ser Phe Thr Ser Pro Thr Val Thr Asp Thr Ser Thr

585 590 595acc ctt cag ccg tgg ggc ttt gcg atc ctg acc cga aac tagaaaaagg 1940Thr Leu Gln Pro Trp Gly Phe Ala Ile Leu Thr Arg Asn

600605610 ccacctcgat tga 1953<210>1146<211>610<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1146Met Leu Lys Asp Leu Thr Gly Leu Arg Glu Leu Val Leu Arg Glu Met 151015 Cys His Ser Ile Ser His Leu Ser Ser Pro Thr Gly Ser Ile Phe Thr

20 25 30Ser Leu Val Ala Met Leu Thr Ser Gln Ser Phe Ser Val Trp Ala Pro

35 40 45Leu Pro His Asp Val His Leu Ile Leu Asn Gly Glu Thr Leu Pro Met

50 55 60His Lys Thr Glu Gly Ser Trp Trp Arg Ala Glu Ile Ala Pro Lys Ala 65 70 75 80Gly Asp Arg Tyr Gly Phe Ser Leu Phe Asp Gly Ser Ser Trp Ser Lys

85 90 95Thr Leu Pro Asp Pro Arg Ser Thr Ser Gln Pro Asp Gly Val His Gly

100 105 110Leu Ser Glu Val Ser Asp Asp Ser Tyr Leu Trp Gly Asp Gln Gln Trp

115120 125Thr Gly Arg Ile Leu Pro Gly Ser Val Leu Tyr Glu Leu His Val Gly

130 135 140Thr Phe Ser Glu Asp Gly Thr Phe Glu Gly Val Val Asp Lys Leu Pro145 150 155 160Tyr Leu Arg Asp Leu Gly Val Thr Ala Ile Glu Leu Leu Pro Val Gln

165 170 175Pro Phe Gly Gly Asn Arg Asn Trp Gly Tyr Asp Gly Val Leu Trp His

180 185 190Ala Val His Ala Gly Tyr Gly Gly Pro Ala Gly Leu Lys Lys Leu Ile

195 200 205Asp Ala Ser His Gln Ala Gly Ile Ala Val Tyr Leu Asp Val Val Tyr

210 215 220Asn His Phe Gly Pro Asp Gly Asn Tyr Asn Gly Gln Phe Gly Pro Tyr225 230 235 240Thr Ser Gly Gly Ser Thr Gly Trp Gly Asp Val Val Asn Ile Asn Gly

245 250 255His Asp Ser Asp Glu Val Arg Asn Tyr Ile Leu Asp Ala Ala Arg Gln

260 265 270Trp Phe Glu Asp Phe His Val Asp Gly Leu Arg Leu Asp Ala Val His

275 280 285Ser Leu Asp Asp Arg Gly Ala Tyr Ser Leu Leu Ala Gln Leu Thr Met

290 295 300Val Ala Glu Asp Val Ser Ala Gln Thr Gly Ile Pro Arg Ser Leu Ile305 310 315 320Ala Glu Ser Glu Leu Asn Asp Pro Lys Phe Val Thr Ser Arg Glu Ala

325 330 335Gly Gly Phe Gly Leu Asp Ala Gln Trp Val Asp Asp Ile His His Ala

340 345 350Leu His Ala Leu Val Ser Gly Glu Arg Asn Gly Tyr Tyr Ser Asp Phe

355 360 365Gly Ser Val Asp Thr Leu Ala Lys Thr Leu Arg Glu Val Phe Glu His

370 375 380Thr Gly Asn Tyr Ser Thr Tyr Arg Gly Arg Asn His Gly Arg Pro Val385 390 395 400His Pro Asp Ile Thr Pro Ala Ser Arg Phe Val Thr Tyr Thr Thr Thr

405 410 415His Asp Gln Thr Gly Asn Arg Ala Ile Gly Asp Arg Pro Ser Thr Thr

420 425 430Leu Thr Pro Glu Gln Gln Val Leu Lys Ala Ala Ile Ile Tyr Ser Ser

435 440 445Pro Tyr Thr Pro Met Leu Phe Met Gly Glu Glu Phe Gly Ala Thr Thr

450 455 460Pro Phe Ala Phe Phe Cys Ser His Thr Asp Pro Glu Leu Asn Arg Leu465 470 475 480Thr Ser Glu Gly Arg Lys Arg Glu Phe Ala Arg Leu Gly Trp Asn Ala

485 490 495Asp Asp Ile Pro Ser Pro Glu Leu Glu Ser Thr Phe Thr Ser Ser Lys

500 505 510Leu Asp Trp Glu Phe Thr Ala Glu Gln Arg Arg Ile Asn Asp Ala Tyr

515 520 525Lys Gln Leu Leu His Leu Arg His Thr Leu Gly Phe Ser Gln Pro Asn

530 535 540Leu Leu Thr Leu Glu Val Glu His Gly Glu Asn Trp Leu Ser Met Ala545 550 555 560Asn Gly Arg Gly Arg Ile Leu Ala Asn Phe Ser Asp Asp Thr Ile Thr

565 570 575Val Pro Leu Gly Gly Glu Leu Ile Tyr Ser Phe Thr Ser Pro Thr Val

580 585 590Thr Asp Thr Ser Thr Thr Leu Gln Pro Trp Gly Phe Ala Ile Leu Thr

595 600 605Arg Asn

610<210>1147<211>832<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (832)<223>RXN02355<400>1147atttttgacc ctccgggggt gatttaacct aaaattccac acaaacgtgt tcgaggtcat 60tagattgata agcatctgtt gttaagaaag gtgacttcct atg tcc tcg att tcc 115

Met Ser Ser Ile Ser

1 5cgc aag acc ggc gcg tca ctt gca gcc acc aca ctg ttg gca gcg atc 163Arg Lys Thr Gly Ala Ser Leu Ala Ala Thr Thr Leu Leu Ala Ala Ile

10 15 20gca ctg gcc ggt tgt agt tca gac tca agc tcc gac tcc aca gat tcc 211Ala Leu Ala Gly Cys Ser Ser Asp Ser Ser Ser Asp Ser Thr Asp Ser

25 30 35acc gct agc gaa ggc gca gac agc cgc ggc ccc atc acc ttt gcg atg 259Thr Ala Ser Glu Gly Ala Asp Ser Arg Gly Pro Ile Thr Phe Ala Met

40 45 50ggc aaa aac gac acc gac aaa gtc att ccg atc atc gac cgc tgg aac 307Gly Lys Asn Asp Thr Asp Lys Val Ile Pro Ile Ile Asp Arg Trp Asn

55 60 65gaa gcc cac ccc gat gag cag gta acg ctc aac gaa ctc gcc ggt gaa 355Glu Ala His Pro Asp Glu Gln Val Thr Leu Asn Glu Leu Ala Gly Glu 70 75 80 85gcc gac gcg cag cgc gaa acc ctc gtg caa tcc ctg cag gcc ggc aac 403Ala Asp Ala Gln Arg Glu Thr Leu Val Gln Ser Leu Gln Ala Gly Asn

90 95 100tct gac tac gac gtc atg gcg ctc gac gtc atc tgg acc gca gac ttc 451Ser Asp Tyr Asp Val Met Ala Leu Asp Val Ile Trp Thr Ala Asp Phe

105 110 115gcg gca aac caa tgg ctc gca cca ctt gaa ggc gac ctc gag gta gac 499Ala Ala Asn Gln Trp Leu Ala Pro Leu Glu Gly Asp Leu Glu Val Asp

120 125 130acc tcc gga ctg ctg caa tcc acc gtg gat tcc gca acc tac aac ggc 547Thr Ser Gly Leu Leu Gln Ser Thr Val Asp Ser Ala Thr Tyr Asn Gly

135 140 145acc ctc tac gca ctg cca cag aac acc aac ggc cag cta ctg ttc cgc 595Thr Leu Tyr Ala Leu Pro Gln Asn Thr Asn Gly Gln Leu Leu Phe Arg150 155 160 165aac acc gaa atc atc cca gaa gca cca gca aac tgg gct gac ctc gtg 643Asn Thr Glu Ile Ile Pro Glu Ala Pro Ala Asn Trp Ala Asp Leu Val

170 175 180gaa tcc tgc acg ctt gct gaa gaa gca ggc gtt gat tgc ctg acc act 691Glu Ser Cys Thr Leu Ala Glu Glu Ala Gly Val Asp Cys Leu Thr Thr

185 190 195cag ctc aag cag tac gaa ggc ctt tca gtg aac acc atc ggc ttc atc 739Gln Leu Lys Gln Tyr Glu Gly Leu Ser Val Asn Thr Ile Gly Phe Ile

200 205 210gaa ggt tgg gga ggc agc gtc cta gac gat gac ggc aaa cgt cac cgt 787Glu Gly Trp Gly Gly Ser Val Leu Asp Asp Asp Gly Lys Arg His Arg

215220225 aga cag cac gac ggc aag gca ggc ctt caa gcg ctt gtc gac ggc 832Arg Gln His Asp Gly Lys Ala Gly Leu Gln Ala Leu Val Asp Gly 230235240<210>1148<211>244<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1148Met Ser Ser Ile Ser Arg Lys Thr Gly Ala Ser Leu Ala Ala Thr Thr 151015 Leu Leu Ala Ala Ile Ala Leu Ala Gly Cys Ser Ser Asp Ser Ser Ser

20 25 30Asp Ser Thr Asp Ser Thr Ala Ser Glu Gly Ala Asp Ser Arg Gly Pro

35 40 45Ile Thr Phe Ala Met Gly Lys Asn Asp Thr Asp Lys Val Ile Pro Ile

50 55 60Ile Asp Arg Trp Asn Glu Ala His Pro Asp Glu Gln Val Thr Leu Asn 65 70 75 80Glu Leu Ala Gly Glu Ala Asp Ala Gln Arg Glu Thr Leu Val Gln Ser

85 90 95Leu Gln Ala Gly Asn Ser Asp Tyr Asp Val Met Ala Leu Asp Val Ile

100 105 110Trp Thr Ala Asp Phe Ala Ala Asn Gln Trp Leu Ala Pro Leu Glu Gly

115 120 125Asp Leu Glu Val Asp Thr Ser Gly Leu Leu Gln Ser Thr Val Asp Ser

130 135 140Ala Thr Tyr Asn Gly Thr Leu Tyr Ala Leu Pro Gln Asn Thr Asn Gly145 150 155 160Gln Leu Leu Phe Arg Asn Thr Glu Ile Ile Pro Glu Ala Pro Ala Asn

165 170 175Trp Ala Asp Leu Val Glu Ser Cys Thr Leu Ala Glu Glu Ala Gly Val

180 185 190Asp Cys Leu Thr Thr Gln Leu Lys Gln Tyr Glu Gly Leu Ser Val Asn

195 200 205Thr Ile Gly Phe Ile Glu Gly Trp Gly Gly Ser Val Leu AspAsp Asp

210215220 Gly Lys Arg His Arg Arg Gln His Asp Gly Lys Ala Gly Leu Gln Ala 225230235240 Leu ValAsp Gly<210>1149<211>609<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (586)<223>RXN02909<400>1149caacgcgaat gaaaacgaac agcgagcagg tctataccca cgacgtcaac gtgtgggcta 60atagtttcct ggattgtttg gcacagtcgg gagaaaactc atg aac cgc gca cga 115

Met Asn Arg Ala Arg

1 5atc gcg acc ata ggc gtt ctt ccg ctt gct tta ctg ctg gcg tcc tgt 163Ile Ala Thr Ile Gly Val Leu Pro Leu Ala Leu Leu Leu Ala Ser Cys

10 15 20ggt tca gac acc gtg gaa atg aca gat tcc acc tgg ttg gtg acc aat 211Gly Ser Asp Thr Val Glu Met Thr Asp Ser Thr Trp Leu Val Thr Asn

25 30 35att tac acc gat cca gat gag tcg aat tcg atc agt aat ctt gtc att 259Ile Tyr Thr Asp Pro Asp Glu Ser Asn Ser Ile Ser Asn Leu Val Ile

40 45 50tcc cag ccc agc tta gat ttt ggc aat tct tcc ctg tct ggt ttc act 307Ser Gln Pro Ser Leu Asp Phe Gly Asn Ser Ser Leu Ser Gly Phe Thr

55 60 65ggc tgt gtg cct ttt acg ggg cgt gcg gaa ttc ttc caa aat ggt gag 355Gly Cys Val Pro Phe Thr Gly Arg Ala Glu Phe Phe Gln Asn Gly Glu 70 75 80 85caa agc tct gtt ctg gat gcc gat tat gtg acc ttg tct tcc ctg gat 403Gln Ser Ser Val Leu Asp Ala Asp Tyr Val Thr Leu Ser Ser Leu Asp

90 95 100ttc gat aaa ctt ccc gat gat tgc caa gga caa gaactc aaa gtt cat 451Phe Asp Lys Leu Pro Asp Asp Cys Gln Gly Gln Glu Leu Lys Val His

105 110 115aac gag ctg gtt gat ctt ctg cct ggt tct ttt gaa atc tcc agg act 499Asn Glu Leu Val Asp Leu Leu Pro Gly Ser Phe Glu Ile Ser Arg Thr

120 125 130tct ggt tca gaa atc ttg ctg act agc gat gtc gat gaa ctc gat cgg 547Ser Gly Ser Glu Ile Leu Leu Thr Ser Asp Val Asp Glu Leu Asp Arg

135140145 cca gca atc cgc ttg gtg tcc tgg atc gcg ccg aca tct taaggtgcca 596Pro Ala Ile Arg Leu Val Ser Trp Ile Ala Pro Thr Ser 150155160 gggcttaaa gtg 609<210>1150<211>162<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1150Met Asn Arg Ala Arg Ile Ala Thr Ile Gly Val Leu Pro Leu Ala Leu 151015 Leu Leu Ala Ser Cys Gly Ser Asp Thr Val Glu Met Thr Asp Ser Thr

20 25 30Trp Leu Val Thr Asn Ile Tyr Thr Asp Pro Asp Glu Ser Asn Ser Ile

35 40 45Ser Asn Leu Val Ile Ser Gln Pro Ser Leu Asp Phe Gly Asn Ser Ser

50 55 60Leu Ser Gly Phe Thr Gly Cys Val Pro Phe Thr Gly Arg Ala Glu Phe 65 70 75 80Phe Gln Asn Gly Glu Gln Ser Ser Val Leu Asp Ala Asp Tyr Val Thr

85 90 95Leu Ser Ser Leu Asp Phe Asp Lys Leu Pro Asp Asp Cys Gln Gly Gln

100 105 110Glu Leu Lys Val His Asn Glu Leu Val Asp Leu Leu Pro Gly Ser Phe

115 120 125Glu Ile Ser Arg Thr Ser Gly Ser Glu Ile Leu Leu Thr Ser Asp Val

130135140 Asp Glu Leu Asp Arg Pro Ala Ile Arg Leu Val Ser Trp Ile Ala Pro 145150155160 Thr Ser<210>1151<211>1590<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1567)<223>RXS00349<400>1151tgtgtacatc acaatggaat tcggggctag agtatctggt gaaccgtgca taaacgacct 60gtgattggac tctttttcct tgcaaaatgt tttccagcgg atg ttg agt ttt gcg 115

Met Leu Ser Phe Ala

1 5acc ctt cgt ggc cgc att tca aca gtt gac gct gca aaa gcc gca cct 163Thr Leu Arg Gly Arg Ile Ser Thr Val Asp Ala Ala Lys Ala Ala Pro

10 15 20ccg cca tcg cca cta gcc ccg att gat ctc act gac cat agt caa gtg 211Pro Pro Ser Pro Leu Ala Pro Ile Asp Leu Thr Asp His Ser Gln Val

25 30 35gcc ggt gtg atg aat ttg gct gcg aga att ggc gat att ttg ctt tct 259Ala Gly Val Met Asn Leu Ala Ala Arg Ile Gly Asp Ile Leu Leu Ser

40 45 50tca ggt acg tca aat agt gac acc aag gta caa gtt cga gca gtg acc 307Ser Gly Thr Ser Asn Ser Asp Thr Lys Val Gln Val Arg Ala Val Thr

55 60 65tct gcg tac ggt ttg tac tac acg cac gtg gat atc acg ttg aat acg 355Ser Ala Tyr Gly Leu Tyr Tyr Thr His Val Asp Ile Thr Leu Asn Thr 70 75 80 85atc acc atc ttc acc aac atc ggt gtg gag agg aag atg ccg gtc aac 403Ile Thr Ile Phe Thr Asn Ile Gly Val Glu Arg Lys Met Pro Val Asn

90 95 100gtg ttt cat gtt gta ggc aag ttg gac acc aac ttc tcc aaa ctg tct 451Val PheHis Val Val Gly Lys Leu Asp Thr Asn Phe Ser Lys Leu Ser

105 110 115gag gtt gac cgt ttg atc cgt tcc att cag gct ggt gcg acc ccg cct 499Glu Val Asp Arg Leu Ile Arg Ser Ile Gln Ala Gly Ala Thr Pro Pro

120 125 130gag gtt gcc gag aaa atc ctg gac gag ttg gag caa tcc cct gcg tct 547Glu Val Ala Glu Lys Ile Leu Asp Glu Leu Glu Gln Ser Pro Ala Ser

135 140 145tat ggt ttc cct gtt gcg ttg ctt ggc tgg gca atg atg ggt ggt gct 595Tyr Gly Phe Pro Val Ala Leu Leu Gly Trp Ala Met Met Gly Gly Ala150 155 160 165gtt gct gtg ctg ttg ggt ggt gga tgg cag gtt tcc cta att gct ttt 643Val Ala Val Leu Leu Gly Gly Gly Trp Gln Val Ser Leu Ile Ala Phe

170 175 180att acc gcg ttc acg atc att gcc acg acg tca ttt ttg gga aag aag 691Ile Thr Ala Phe Thr Ile Ile Ala Thr Thr Ser Phe Leu Gly Lys Lys

185 190 195ggt ttg cct act ttc ttc caa aat gtt gtt ggt ggt ttt att gcc acg 739Gly Leu Pro Thr Phe Phe Gln Asn Val Val Gly Gly Phe Ile Ala Thr

200 205 210ctg cct gca tcg att gct tat tct ttg gcg ttg caa ttt ggt ctt gag 787Leu Pro Ala Ser Ile Ala Tyr Ser Leu Ala Leu Gln Phe Gly Leu Glu

215 220 225atc aaa ccg agc cag atc atc gca tct gga att gtt gtg ctg ttg gca 835Ile Lys Pro Ser Gln Ile Ile Ala Ser Gly Ile Val Val Leu Leu Ala230 235 240 245ggt ttg aca ctc gtg caa tct ctg cag gac ggc atc acg ggc gct ccg 883Gly Leu Thr Leu Val Gln Ser Leu Gln Asp Gly Ile Thr Gly Ala Pro

250 255 260gtg aca gca agt gca cga ttt ttc gaa aca ctc ctg ttt acc ggc ggc 931Val Thr Ala Ser Ala Arg Phe Phe Glu Thr Leu Leu Phe Thr Gly Gly

265 270 275att gtt gct ggc gtg ggt ttg ggc att cag ctt tct gaa atc ttg cat 979Ile Val Ala Gly Val Gly Leu Gly Ile Gln Leu Ser Glu Ile Leu His

280 285 290gtc atg ttg cct gcc atg gag tcc gct gca gca cct aat tat tcg tct 1027Val Met Leu Pro Ala Met Glu Ser Ala Ala Ala Pro Asn Tyr Ser Ser

295 300 305aca ttc gcc cgc att atc gct ggt ggc gtc acc gca gcg gcc ttc gca 1075Thr Phe Ala Arg Ile Ile Ala Gly Gly Val Thr Ala Ala Ala Phe Ala310 315 320 325gtg ggt tgt tac gcg gag tgg tcc tcg gtg att att gcg ggg ctt act 1123Val Gly Cys Tyr Ala Glu Trp Ser Ser Val Ile Ile Ala Gly Leu Thr

330 335 340gcg ctg atg ggt tct gcg ttt tat tac ctc ttc gtt gtt tat tta ggc 1171Ala Leu Met Gly Ser Ala Phe Tyr Tyr Leu Phe Val Val Tyr Leu Gly

345 350 355ccc gtc tct gcc gct gcg att gct gca aca gca gtt ggt ttc act ggt 1219Pro Val Ser Ala Ala Ala Ile Ala Ala Thr Ala Val Gly Phe Thr Gly

360 365 370ggt ttg ctt gcc cgt cga ttc ttg att cca ccg ttg att gtg gcg att 1267Gly Leu Leu Ala Arg Arg Phe Leu Ile Pro Pro Leu Ile Val Ala Ile

375 380 385gcc ggc atc aca cca atg ctt cca ggt cta gca att tac cgc gga atg 1315Ala Gly Ile Thr Pro Met Leu Pro Gly Leu Ala Ile Tyr Arg Gly Met390 395 400 405tac gcc acc ctg aat gat caa aca ctc atg ggt ttc acc aacatt gcg 1363Tyr Ala Thr Leu Asn Asp Gln Thr Leu Met Gly Phe Thr Asn Ile Ala

410 415 420gtt gct tta gcc act gct tca tca ctt gcc gct ggc gtg gtt ttg ggt 1411Val Ala Leu Ala Thr Ala Ser Ser Leu Ala Ala Gly Val Val Leu Gly

425 430 435gag tgg att gcc cgc agg cta cgt cgt cca cca cgc ttc aac cca tac 1459Glu Trp Ile Ala Arg Arg Leu Arg Arg Pro Pro Arg Phe Asn Pro Tyr

440 445 450cgt gca ttt acc aag gcg aat gag ttc tcc ttc cag gag gaa gct gag 1507Arg Ala Phe Thr Lys Ala Asn Glu Phe Ser Phe Gln Glu Glu Ala Glu

455460465 cag aat cag cgc cgg cag aga aaa cgt cca aag act aat cag aga ttc 1555Gln Asn Gln Arg Arg Gln Arg Lys Arg Pro Lys Thr Asn Gln Arg Phe 470475480485 ggt aat aaa agg taaaaatcaa cctgcttagg cgt 1590Gly Asn Lys Arg<210>1152<211>489<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1152Met Leu Ser Phe Ala Thr Leu Arg Gly Arg Ile Ser Thr Val Asp Ala 151015 Ala Lys Ala Ala Pro Pro Pro Ser Pro Leu Ala Pro Ile Asp Leu Thr

20 25 30Asp His Ser Gln Val Ala Gly Val Met Asn Leu Ala Ala Arg Ile Gly

35 40 45Asp Ile Leu Leu Ser Ser Gly Thr Ser Asn Ser Asp Thr Lys Val Gln

50 55 60Val Arg Ala Val Thr Ser Ala Tyr Gly Leu Tyr Tyr Thr His Val Asp 65 70 75 80Ile Thr Leu Asn Thr Ile Thr Ile Phe Thr Asn Ile Gly Val Glu Arg

85 90 95Lys Met Pro Val Asn Val Phe His Val Val Gly Lys Leu Asp Thr Asn

100 105 110Phe Ser Lys Leu Ser Glu Val Asp Arg Leu Ile Arg Ser Ile Gln Ala

115 120 125Gly Ala Thr Pro Pro Glu Val Ala Glu Lys Ile Leu Asp Glu Leu Glu

130 135 140Gln Ser Pro Ala Ser Tyr Gly Phe Pro Val Ala Leu Leu Gly Trp Ala145 150 155 160Met Met Gly Gly Ala Val Ala Val Leu Leu Gly Gly Gly Trp Gln Val

165 170 175Ser Leu Ile Ala Phe Ile Thr Ala Phe Thr Ile Ile Ala Thr Thr Ser

180 185 190Phe Leu Gly Lys Lys Gly Leu Pro Thr Phe Phe Gln Asn Val Val Gly

195 200 205Gly Phe Ile Ala Thr Leu Pro Ala Ser Ile Ala Tyr Ser Leu Ala Leu

210 215 220Gln Phe Gly Leu Glu Ile Lys Pro Ser Gln Ile Ile Ala Ser Gly Ile225 230 235 240Val Val Leu Leu Ala Gly Leu Thr Leu Val Gln Ser Leu Gln Asp Gly

245 250 255Ile Thr Gly Ala Pro Val Thr Ala Ser Ala Arg Phe Phe Glu Thr Leu

260 265 270Leu Phe Thr Gly Gly Ile Val Ala Gly Val Gly Leu Gly Ile Gln Leu

275 280 285Ser Glu Ile Leu His Val Met Leu Pro Ala Met Glu Ser Ala Ala Ala

290 295 300Pro Asn Tyr Ser Ser Thr Phe Ala Arg Ile Ile Ala Gly Gly Val Thr305 310 315 320Ala Ala Ala Phe Ala Val Gly Cys Tyr Ala Glu Trp Ser Ser Val Ile

325 330 335Ile Ala Gly Leu Thr Ala Leu Met Gly Ser Ala Phe Tyr Tyr Leu Phe

340 345 350Val Val Tyr Leu Gly Pro Val Ser Ala Ala Ala Ile Ala Ala Thr Ala

355 360 365Val Gly Phe Thr Gly Gly Leu Leu Ala Arg Arg Phe Leu Ile Pro Pro

370 375 380Leu Ile Val Ala Ile Ala Gly Ile Thr Pro Met Leu Pro Gly Leu Ala385 390 395 400Ile Tyr Arg Gly Met Tyr Ala Thr Leu Asn Asp Gln Thr Leu Met Gly

405 410 415Phe Thr Asn Ile Ala Val Ala Leu Ala Thr Ala Ser Ser Leu Ala Ala

420 425 430Gly Val Val Leu Gly Glu Trp Ile Ala Arg Arg Leu Arg Arg Pro Pro

435 440 445Arg Phe Asn Pro Tyr Arg Ala Phe Thr Lys Ala Asn Glu Phe Ser Phe

450 455 460Gln Glu Glu Ala Glu Gln Asn Gln Arg Arg Gln Arg Lys Arg Pro Lys465 470 475 480Thr Asn Gln Arg Phe Gly Asn Lys Arg

485<210>1153<211>440<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (417)<223>RXS03183<400>1153gaa gcc gaa gca acc gca ggc aaa ttc gaa gta cag ccc ctc gta ggt 48Glu Ala Glu Ala Thr Ala Gly Lys Phe Glu Val Gln Pro Leu Val Gly 151015 aaa gac ggc gtc ggc gta tcc acc ctt ggt ggc tac aac aac ggc atc 96Lys Asp Gly Val Gly Val Ser Thr Leu Gly Gly Tyr Asn Asn Gly Ile

20 25 30aac gtc aac tcc gaa aac aag gca acc gcc cgc gac ttc atc gaa ttc 144Asn Val Asn Ser Glu Asn Lys Ala Thr Ala Arg Asp Phe Ile Glu Phe

35 40 45atc atc aac gaa gag aac caa acc tgg ttc gcg gac aac tcc ttc cca 192Ile Ile Asn Glu Glu Asn Gln Thr Trp Phe Ala Asp Asn Ser Phe Pro

50 55 60cca gtt ctg gca tcc atc tac gat gat gag tcc ctt gtt gag cag tac 240Pro Val Leu Ala Ser Ile Tyr Asp Asp Glu Ser Leu Val Glu Gln Tyr 65 70 75 80cca tac ctg cca gca ctg aag gaa tcc ctg gaa aac gca gca cca cgc 288Pro Tyr Leu Pro Ala Leu Lys Glu Ser Leu Glu Asn Ala Ala Pro Arg

85 90 95cca gtg tct cct ttc tac cca gcc atc tcc aag gca atc cag gac aac 336Pro Val Ser Pro Phe Tyr Pro Ala Ile Ser Lys Ala Ile Gln Asp Asn

100 105 110gcc tac gca gcg ctt aac ggc aac gtc gac gtt gac cag gca acc acc 384Ala Tyr Ala Ala Leu Asn Gly Asn Val Asp Val Asp Gln Ala Thr Thr

115 120 125gat atg aag gca gcg atc gaa aac gct tcc agc tagttcggta atttagttca 437Asp Met Lys Ala Ala Ile Glu Asn Ala Ser Ser

130135 ttc 440<210>1154<211>139<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1154Glu Ala Glu Ala Thr Ala Gly Lys Phe Glu Val Gln Pro Leu Val Gly 151015 Lys Asp Gly Val Gly Val Ser Thr Leu Gly Gly Tyr Asn Asn Gly Ile

20 25 30Asn Val Asn Ser Glu Asn Lys Ala Thr Ala Arg Asp Phe Ile Glu Phe

35 40 45Ile Ile Asn Glu Glu Asn Gln Thr Trp Phe Ala Asp Asn Ser Phe Pro

50 55 60Pro Val Leu Ala Ser Ile Tyr Asp Asp Glu Ser Leu Val Glu Gln Tyr 65 70 75 80Pro Tyr Leu Pro Ala Leu Lys Glu Ser Leu Glu Asn Ala Ala Pro Arg

85 90 95Pro Val Ser Pro Phe Tyr Pro Ala Ile Ser Lys Ala Ile Gln Asp Asn

100 105 110Ala Tyr Ala Ala Leu Asn Gly Asn Val Asp Val Asp Gln Ala Thr Thr

115 120 125Asp Met Lys Ala Ala Ile Glu Asn Ala Ser Ser

130135<210>1155<211>1212<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1189)<223>RXC00874<400>1155agctgttccc taccattgct gaacgggagt ggattgtcac tttagcccctcacggattct 60tctggtttga tctcaccgcc gatgaaaagg acgatatgga atg agc att ggc caa 115

Met Ser Ile Gly Gln

1 5cac atc atc acc gag cgt ttc tac ggc gcc aag tcc cac acc atc gac 163His Ile Ile Thr Glu Arg Phe Tyr Gly Ala Lys Ser His Thr Ile Asp

10 15 20aac gta gat att gtg ttg tcc cgc gaa tgt ggc gag aac act ttg gct 211Asn Val Asp Ile Val Leu Ser Arg Glu Cys Gly Glu Asn Thr Leu Ala

25 30 35gta gtg cgc atc aac aat gcg ctg tat cag ttg ttg gtc aat gat gat 259Val Val Arg Ile Asn Asn Ala Leu Tyr Gln Leu Leu Val Asn Asp Asp

40 45 50ggc aaa gat gtt ctc aac gac cac gta gaa gag gtc ggt gcg agt ttc 307Gly Lys Asp Val Leu Asn Asp His Val Glu Glu Val Gly Ala Ser Phe

55 60 65gga gca tgg act ggc agc tct gct ttt ccc att ggc cct ttc act cca 355Gly Ala Trp Thr Gly Ser Ser Ala Phe Pro Ile Gly Pro Phe Thr Pro 70 75 80 85ctc ggc aca gaa caa tcc aat agc tct ttc atc acc gcc gac aat aaa 403Leu Gly Thr Glu Gln Ser Asn Ser Ser Phe Ile Thr Ala Asp Asn Lys

90 95 100gcg atc gtg aaa tac ttc cgc aaa tta gaa tcc ggg caa aac ccc gat 451Ala Ile Val Lys Tyr Phe Arg Lys Leu Glu Ser Gly Gln Asn Pro Asp

105 110 115gtg gag cta att tct aaa att tcc tcc tgc ccc aac atc gcg ccc atc 499Val Glu Leu Ile Ser Lys Ile Ser Ser Cys Pro Asn Ile Ala Pro Ile

120 125 130ctg ggt ttt tcc tcc gct gag atc tcc ggg gct aac tac acc ctg gtc 547Leu Gly Phe Ser Ser Ala Glu Ile Ser Gly Ala Asn Tyr Thr Leu Val

135 140 145atg gcg cag cag tac gtt cca ggt ttg gat ggc tgg tca cac gcg ctg 595Met Ala Gln Gln Tyr Val Pro Gly Leu Asp Gly Trp Ser His Ala Leu150 155 160 165act act acc tct ggc agc ttt gca gag gat gca gaa aag atc ggc gaa 643Thr Thr Thr Ser Gly Ser Phe Ala Glu Asp Ala Glu Lys Ile Gly Glu

170 175 180gcc acc cgc aat gtt cac act gct ctt gca tcg gcc ttc cct act cgg 691Ala Thr Arg Asn Val His Thr Ala Leu Ala Ser Ala Phe Pro Thr Arg

185 190 195gta gtt ccc gta gaa gca ctc gcc gat gcg ctc act acc cgc ctt aat 739Val Val Pro Val Glu Ala Leu Ala Asp Ala Leu Thr Thr Arg Leu Asn

200 205210gaa cta atc tcc caa gca ccc gaa atc gcc cgc ttc aaa gaa gca gcc 787Glu Leu Ile Ser Gln Ala Pro Glu Ile Ala Arg Phe Lys Glu Ala Ala

215 220 225atc gac ctc tac caa tcg ttg gaa ggc gaa gcc cac atc caa cgc atc 835Ile Asp Leu Tyr Gln Ser Leu Glu Gly Glu Ala His Ile Gln Arg Ile230 235 240 245cac ggt gac ctc cac ttg ggg cag ctc atc aaa acc ccc gaa cgc tac 883His Gly Asp Leu His Leu Gly Gln Leu Ile Lys Thr Pro Glu Arg Tyr

250 255 260atc ctc atc gat ttc gaa ggc gaa cct gcc cgc cca ctt aat caa cga 931Ile Leu Ile Asp Phe Glu Gly Glu Pro Ala Arg Pro Leu Asn Gln Arg

265 270 275cgc ctc ccc gac tct ccc ctg aaa gat ctc gcc ggc atc atc aga tcc 979Arg Leu Pro Asp Ser Pro Leu Lys Asp Leu Ala Gly Ile Ile Arg Ser

280 285 290atc gac tac gca gcc tac ttc gac ggc gaa cac acc caa tgg gcc aac 1027Ile Asp Tyr Ala Ala Tyr Phe Asp Gly Glu His Thr Gln Trp Ala Asn

295 300 305gaa gcc acc gcg cta ttc ctc gac ggc tac gga tca att gaa gac caa 1075Glu Ala Thr Ala Leu Phe Leu Asp Gly Tyr Gly Ser Ile Glu Asp Gln310 315 320 325gaa ctc ctc aat gcc tac att ctg gac aag gcg ttg tac gag gtt gcc 1123Glu Leu Leu Asn Ala Tyr Ile Leu Asp Lys Ala Leu Tyr Glu Val Ala

330 335 340tat gaa ata aac aac cgc ccc gac tgg gtg aaa atc cca ctc gag gcg 1171Tyr Glu Ile Asn Asn Arg Pro Asp Trp Val Lys Ile Pro Leu Glu Ala

345 350 355gtc gaa agg ctt cta gac tagttagtta ctctgcgtca aac 1212Val Glu Arg Leu Leu Asp

360<210>1156<211>363<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>1156Met Ser Ile Gly Gln His Ile Ile Thr Glu Arg Phe Tyr Gly Ala Lys 151015 Ser His Thr Ile Asp Asn Val Asp Ile Val Leu Ser Arg Glu Cys Gly

20 25 30Glu Asn Thr Leu Ala Val Val Arg Ile Asn Asn Ala Leu Tyr Gln Leu

35 40 45Leu Val Asn Asp Asp Gly Lys Asp Val Leu Asn Asp His Val Glu Glu

50 55 60Val Gly Ala Ser Phe Gly Ala Trp Thr Gly Ser Ser Ala Phe Pro Ile 65 70 75 80Gly Pro Phe Thr Pro Leu Gly Thr Glu Gln Ser Asn Ser Ser Phe Ile

85 90 95Thr Ala Asp Asn Lys Ala Ile Val Lys Tyr Phe Arg Lys Leu Glu Ser

100 105 110Gly Gln Asn Pro Asp Val Glu Leu Ile Ser Lys Ile Ser Ser Cys Pro

115 120 125Asn Ile Ala Pro Ile Leu Gly Phe Ser Ser Ala Glu Ile Ser Gly Ala

130 135 140Asn Tyr Thr Leu Val Met Ala Gln Gln Tyr Val Pro Gly Leu Asp Gly145 150 155 160Trp Ser His Ala Leu Thr Thr Thr Ser Gly Ser Phe Ala Glu Asp Ala

165 170 175Glu Lys Ile Gly Glu Ala Thr Arg Asn Val His Thr Ala Leu Ala Ser

180 185 190Ala Phe Pro Thr Arg Val Val Pro Val Glu Ala Leu Ala Asp Ala Leu

195 200 205Thr Thr Arg Leu Asn Glu Leu Ile Ser Gln Ala Pro Glu Ile Ala Arg

210 215 220Phe Lys Glu Ala Ala Ile Asp Leu Tyr Gln Ser Leu Glu Gly Glu Ala225 230 235 240His Ile Gln Arg Ile His Gly Asp Leu His Leu Gly Gln Leu Ile Lys

245 250 255Thr Pro Glu Arg Tyr Ile Leu Ile Asp Phe Glu Gly Glu Pro Ala Arg

260 265 270Pro Leu Asn Gln Arg Arg Leu Pro Asp Ser Pro Leu Lys Asp Leu Ala

275 280 285Gly Ile Ile Arg Ser Ile Asp Tyr Ala Ala Tyr Phe Asp Gly Glu His

290 295 300Thr Gln Trp Ala Asn Glu Ala Thr Ala Leu Phe Leu Asp Gly Tyr Gly305 310 315 320Ser Ile Glu Asp Gln Glu Leu Leu Asn Ala Tyr Ile Leu Asp Lys Ala

325 330 335Leu Tyr Glu Val Ala Tyr Glu Ile Asn Asn Arg Pro Asp Trp Val Lys

340 345 350Ile Pro Leu Glu Ala Val Glu Arg Leu Leu Asp

355360<210>1157<211>18<212>DNA<213>Artificial sequence<220><223>Artificial sequence description: primer<400>1157ggaaacagta tgaccatg 18<210>1158<211>17<212>DNA<213>artificial sequence<220><223>artificial sequence description: primer<400>1158gtaaaacgac ggccagt 17

Claims (38)

1. A nucleic acid molecule isolated from Corynebacterium glutamicum encoding a metabolic pathway protein, or a fragment thereof, provided that the nucleic acid molecule does not include any of the F-designated genes listed in Table 1.

2. The isolated nucleic acid molecule of claim 1, wherein said metabolic pathway protein is selected from the group consisting of proteins involved in the metabolism of amino acids, vitamins, cofactors, trophic factors, nucleotides, nucleosides, or trehalose.

3. An isolated Corynebacterium glutamicum nucleic acid molecule selected from the group consisting of those sequences set forth as odd-numbered SEQ ID NOs of the sequence Listing, or a portion thereof, provided that the nucleic acid molecule does not include any of the F-designated genes set forth in Table 1.

4. An isolated nucleic acid molecule encoding a polypeptide sequence selected from the group consisting of those sequences set forth as even-numbered SEQ ID NOs of the sequence Listing, provided that the nucleic acid molecule does not include any of the F-designated genes set forth in Table 1.

5. An isolated nucleic acid molecule encoding a naturally occurring allelic variant of a polypeptide selected from the group consisting of the amino acid sequences of the sequences set forth as even-numbered SEQ ID NOs of the sequence Listing, provided that the nucleic acid molecule does not include any of the F-designated genes set forth in Table 1.

6. An isolated nucleic acid molecule comprising a nucleotide sequence which is at least 50% homologous to a nucleotide sequence selected from the group consisting of those sequences set forth as odd-numbered SEQ ID NOs of the sequence Listing, or a portion thereof, provided that the nucleic acid molecule does not include any of the F-designated genes set forth in Table 1.

7. An isolated nucleic acid molecule comprising a fragment of at least 15 nucleotides from a nucleic acid comprising a nucleotide sequence selected from the group consisting of those sequences set forth as odd-numbered SEQ ID NOs of the sequence Listing, provided that the nucleic acid molecule does not include any of the F-designated genes set forth in Table 1.

8. An isolated nucleic acid molecule which hybridizes to the nucleic acid molecule of any one of claims 1-7 under stringent conditions.

9. An isolated nucleic acid molecule comprising the nucleic acid molecule of any one of claims 1-8, or a portion thereof, and a nucleotide sequence encoding a heterologous polypeptide.

10. A vector comprising the nucleic acid molecule of any one of claims 1-9.

11. The vector of claim 10, which is an expression vector.

12. A host cell transfected with the expression vector of claim 11.

13. The host cell of claim 12, wherein the cell is a microorganism.

14. The host cell of claim 13, wherein the cell belongs to the genus corynebacterium or brevibacterium.

15. The host cell of claim 12, wherein expression of said nucleic acid molecule results in modulation of production of a fine chemical by said cell.

16. The host cell of claim 15, wherein said fine chemical is selected from the group consisting of: organic acids, proteinogenic amino acids, nonproteinogenic amino acids, purine and pyrimidine bases, nucleosides, nucleotides, lipids, saturated and unsaturated fatty acids, diols, sugars, aromatic compounds, vitamins, cofactors, polyketides and enzymes.

17. A method of producing a polypeptide comprising culturing a host cell in a suitable culture medium, thereby producing the polypeptide.

18. An isolated metabolic pathway polypeptide from corynebacterium glutamicum, or a fragment thereof.

19. The protein of claim 18, wherein said metabolic pathway protein is selected from the group consisting of proteins involved in the metabolism of amino acids, vitamins, cofactors, trophic factors, nucleotides, nucleosides, or trehalose.

20. An isolated polypeptide comprising an amino acid sequence selected from the group consisting of those sequences set forth as even-numbered SEQ ID NOs of the sequence Listing, provided that the amino acid sequence is not encoded by any of the F-designated genes set forth in Table 1.

21. An isolated polypeptide comprising a naturally occurring allelic variant of a polypeptide comprising a sequence selected from the group consisting of those sequences set forth as even-numbered SEQ ID NOs of the sequence Listing, or a portion thereof, provided that the amino acid sequence is not encoded by any of the F-designated genes set forth in Table 1.

22. The isolated polypeptide of any one of claims 18-21, further comprising a heterologous amino acid sequence.

23. An isolated polypeptide encoded by a nucleic acid molecule comprising a nucleotide sequence that is at least 50% homologous to a nucleic acid selected from the group consisting of the sequences set forth as odd-numbered SEQ ID NOs of the sequence Listing, provided that the nucleic acid molecule does not include any of the F-designated nucleic acid molecules set forth in Table 1.

24. An isolated polypeptide comprising an amino acid sequence that is at least 50% homologous to an amino acid sequence selected from the group consisting of those sequences set forth as even-numbered SEQ ID NOs of the sequence Listing, provided that the amino acid sequence is not encoded by any of the F-designated genes set forth in Table 1.

25. A method for producing a fine chemical, comprising culturing a cell containing the vector of claim 12, thereby producing the fine chemical.

26. The method of claim 25, wherein said method further comprises the step of recovering a fine chemical from said culture.

27. The method of claim 25, wherein said method further comprises the step of transfecting said cell with the vector of claim 11, which results in the production of a cell containing the vector.

28. The method of claim 25, wherein said cell belongs to the genus corynebacterium or brevibacterium.

29. The method of claim 25, wherein said cell is selected from the group consisting of:corynebacterium glutamicum, Corynebacterium lividum, Corynebacterium lilium, Corynebacterium acetoacidophilum, Corynebacterium acetoglutamicum, Corynebacterium acetoacidophilum, Corynebacterium ammoniagenes, Corynebacterium fujiiokense, Corynebacterium nitrilobacterium nitrilophilum, Brevibacterium ammoniagenes, Brevibacterium butyricum, Brevibacterium flavum, Brevibacterium Schizoctonicum, Brevibacterium ketoglutarate, Brevibacterium ketoketoketosynthase product, Brevibacterium lactofermentum, Brevibacterium expansum, Brevibacterium paraffinum, and the strains listed in Table 3.

30. The method of claim 25, wherein expression of the nucleic acid molecule of said vector results in modulation of fine chemical production by said cell.

31. The method of claim 25, wherein said fine chemical is selected from the group consisting of: organic acids, non-proteinogenic amino acids, purine and pyrimidine bases, nucleosides, nucleotides, lipids, saturated and unsaturated fatty acids, diols, sugars, aromatic compounds, vitamins, cofactors, polyketides and enzymes.

32. The method of claim 25, wherein said fine chemical is an amino acid.

33. The method of claim 32, wherein said amino acid is selected from the group consisting of: lysine, glutamic acid, glutamine, alanine, aspartic acid, glycine, serine, threonine, methionine, cysteine, valine, leucine, isoleucine, arginine, proline, histidine, tyrosine, phenylalanine, tryptophan.

34. A method for producing a fine chemical, comprising culturing a cell whose genomic DNA has been altered by insertion of a nucleic acid molecule of any one of claims 1-9.

35. A method of diagnosing the presence or activity of corynebacterium diphtheriae in a subject, comprising detecting the presence of one or more of SEQ ID NOs 1 through 1156 of the sequence listing in the subject, provided that the sequences are not or are not encoded by any of the F-designated sequences set forth in table 1, thereby diagnosing the presence or activity of corynebacterium diphtheriae in the subject.

36. A host cell comprising a nucleic acid molecule selected from the group consisting of the nucleic acid molecules set forth as odd-numbered SEQ ID NOs of the sequence Listing, wherein the nucleic acid molecule is disrupted.

37. A host cell comprising a nucleic acid molecule selected from the group consisting of the nucleic acid molecules set forth as odd-numbered seq id nos of the sequence listing, wherein the nucleic acid molecule comprises one or more nucleic acid modifications to the sequences set forth as odd-numbered seq id nos of the sequence listing.

38. A host cell comprising a nucleic acid molecule selected from the group consisting of the nucleic acid molecules set forth as odd-numbered SEQ ID NOs of the sequence Listing, wherein the regulatory region of the nucleic acid molecule is modified relative to the wild-type regulatory region of the molecule.